data_9GA8
# 
_entry.id   9GA8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GA8         pdb_00009ga8 10.2210/pdb9ga8/pdb 
WWPDB D_1292140379 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-04 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GA8 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 alessia.ruggiero@unina.it Alessia Ruggiero   ? 'principal investigator/group leader' 0000-0002-3508-385X 
3 luigi.vitagliano@cnr.it   Luigi   Vitagliano ? 'principal investigator/group leader' 0000-0002-3032-3375 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ruggiero, A.'   1 ? 
'Barra, G.'      2 ? 
'Ghilardi, O.'   3 ? 
'Scala, M.C.'    4 ? 
'Sala, M.'       5 ? 
'Di Micco, S.'   6 ? 
'Bifulco, G.'    7 ? 
'Campiglia, P.'  8 ? 
'Vitagliano, L.' 9 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            308 
_citation.language                  ? 
_citation.page_first                142600 
_citation.page_last                 142600 
_citation.title                     
;Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.142600 
_citation.pdbx_database_id_PubMed   40157693 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Di Micco, S.'   1 ? 
primary 'Scala, M.C.'    2 ? 
primary 'Sala, M.'       3 ? 
primary 'Barra, G.'      4 ? 
primary 'Ghilardi, O.'   5 ? 
primary 'Campiglia, P.'  6 ? 
primary 'Bifulco, G.'    7 ? 
primary 'Vitagliano, L.' 8 ? 
primary 'Ruggiero, A.'   9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Annexin A4'  36760.605 1   ? ? ? ? 
2 non-polymer syn 'CALCIUM ION' 40.078    3   ? ? ? ? 
3 non-polymer syn 'SULFATE ION' 96.063    4   ? ? ? ? 
4 water       nat water         18.015    171 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;35-beta calcimedin,Annexin IV,Annexin-4,Carbohydrate-binding protein p33/p41,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PP4-X,Placental anticoagulant protein II,PAP-II,Protein II
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDDH
HHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDDH
HHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION' CA  
3 'SULFATE ION' SO4 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   LYS n 
1 5   GLY n 
1 6   GLY n 
1 7   THR n 
1 8   VAL n 
1 9   LYS n 
1 10  ALA n 
1 11  ALA n 
1 12  SER n 
1 13  GLY n 
1 14  PHE n 
1 15  ASN n 
1 16  ALA n 
1 17  MET n 
1 18  GLU n 
1 19  ASP n 
1 20  ALA n 
1 21  GLN n 
1 22  THR n 
1 23  LEU n 
1 24  ARG n 
1 25  LYS n 
1 26  ALA n 
1 27  MET n 
1 28  LYS n 
1 29  GLY n 
1 30  LEU n 
1 31  GLY n 
1 32  THR n 
1 33  ASP n 
1 34  GLU n 
1 35  ASP n 
1 36  ALA n 
1 37  ILE n 
1 38  ILE n 
1 39  SER n 
1 40  VAL n 
1 41  LEU n 
1 42  ALA n 
1 43  TYR n 
1 44  ARG n 
1 45  ASN n 
1 46  THR n 
1 47  ALA n 
1 48  GLN n 
1 49  ARG n 
1 50  GLN n 
1 51  GLU n 
1 52  ILE n 
1 53  ARG n 
1 54  THR n 
1 55  ALA n 
1 56  TYR n 
1 57  LYS n 
1 58  SER n 
1 59  THR n 
1 60  ILE n 
1 61  GLY n 
1 62  ARG n 
1 63  ASP n 
1 64  LEU n 
1 65  ILE n 
1 66  ASP n 
1 67  ASP n 
1 68  LEU n 
1 69  LYS n 
1 70  SER n 
1 71  GLU n 
1 72  LEU n 
1 73  SER n 
1 74  GLY n 
1 75  ASN n 
1 76  PHE n 
1 77  GLU n 
1 78  GLN n 
1 79  VAL n 
1 80  ILE n 
1 81  VAL n 
1 82  GLY n 
1 83  MET n 
1 84  MET n 
1 85  THR n 
1 86  PRO n 
1 87  THR n 
1 88  VAL n 
1 89  LEU n 
1 90  TYR n 
1 91  ASP n 
1 92  VAL n 
1 93  GLN n 
1 94  GLU n 
1 95  LEU n 
1 96  ARG n 
1 97  ARG n 
1 98  ALA n 
1 99  MET n 
1 100 LYS n 
1 101 GLY n 
1 102 ALA n 
1 103 GLY n 
1 104 THR n 
1 105 ASP n 
1 106 GLU n 
1 107 GLY n 
1 108 CYS n 
1 109 LEU n 
1 110 ILE n 
1 111 GLU n 
1 112 ILE n 
1 113 LEU n 
1 114 ALA n 
1 115 SER n 
1 116 ARG n 
1 117 THR n 
1 118 PRO n 
1 119 GLU n 
1 120 GLU n 
1 121 ILE n 
1 122 ARG n 
1 123 ARG n 
1 124 ILE n 
1 125 SER n 
1 126 GLN n 
1 127 THR n 
1 128 TYR n 
1 129 GLN n 
1 130 GLN n 
1 131 GLN n 
1 132 TYR n 
1 133 GLY n 
1 134 ARG n 
1 135 SER n 
1 136 LEU n 
1 137 GLU n 
1 138 ASP n 
1 139 ASP n 
1 140 ILE n 
1 141 ARG n 
1 142 SER n 
1 143 ASP n 
1 144 THR n 
1 145 SER n 
1 146 PHE n 
1 147 MET n 
1 148 PHE n 
1 149 GLN n 
1 150 ARG n 
1 151 VAL n 
1 152 LEU n 
1 153 VAL n 
1 154 SER n 
1 155 LEU n 
1 156 SER n 
1 157 ALA n 
1 158 GLY n 
1 159 GLY n 
1 160 ARG n 
1 161 ASP n 
1 162 GLU n 
1 163 GLY n 
1 164 ASN n 
1 165 TYR n 
1 166 LEU n 
1 167 ASP n 
1 168 ASP n 
1 169 ALA n 
1 170 LEU n 
1 171 VAL n 
1 172 ARG n 
1 173 GLN n 
1 174 ASP n 
1 175 ALA n 
1 176 GLN n 
1 177 ASP n 
1 178 LEU n 
1 179 TYR n 
1 180 GLU n 
1 181 ALA n 
1 182 GLY n 
1 183 GLU n 
1 184 LYS n 
1 185 LYS n 
1 186 TRP n 
1 187 GLY n 
1 188 THR n 
1 189 ASP n 
1 190 GLU n 
1 191 VAL n 
1 192 LYS n 
1 193 PHE n 
1 194 LEU n 
1 195 THR n 
1 196 VAL n 
1 197 LEU n 
1 198 CYS n 
1 199 SER n 
1 200 ARG n 
1 201 ASN n 
1 202 ARG n 
1 203 ASN n 
1 204 HIS n 
1 205 LEU n 
1 206 LEU n 
1 207 HIS n 
1 208 VAL n 
1 209 PHE n 
1 210 ASP n 
1 211 GLU n 
1 212 TYR n 
1 213 LYS n 
1 214 ARG n 
1 215 ILE n 
1 216 SER n 
1 217 GLN n 
1 218 LYS n 
1 219 ASP n 
1 220 ILE n 
1 221 GLU n 
1 222 GLN n 
1 223 SER n 
1 224 ILE n 
1 225 LYS n 
1 226 SER n 
1 227 GLU n 
1 228 THR n 
1 229 SER n 
1 230 GLY n 
1 231 SER n 
1 232 PHE n 
1 233 GLU n 
1 234 ASP n 
1 235 ALA n 
1 236 LEU n 
1 237 LEU n 
1 238 ALA n 
1 239 ILE n 
1 240 VAL n 
1 241 LYS n 
1 242 CYS n 
1 243 MET n 
1 244 ARG n 
1 245 ASN n 
1 246 LYS n 
1 247 SER n 
1 248 ALA n 
1 249 TYR n 
1 250 PHE n 
1 251 ALA n 
1 252 GLU n 
1 253 LYS n 
1 254 LEU n 
1 255 TYR n 
1 256 LYS n 
1 257 SER n 
1 258 MET n 
1 259 LYS n 
1 260 GLY n 
1 261 LEU n 
1 262 GLY n 
1 263 THR n 
1 264 ASP n 
1 265 ASP n 
1 266 ASN n 
1 267 THR n 
1 268 LEU n 
1 269 ILE n 
1 270 ARG n 
1 271 VAL n 
1 272 MET n 
1 273 VAL n 
1 274 SER n 
1 275 ARG n 
1 276 ALA n 
1 277 GLU n 
1 278 ILE n 
1 279 ASP n 
1 280 MET n 
1 281 LEU n 
1 282 ASP n 
1 283 ILE n 
1 284 ARG n 
1 285 ALA n 
1 286 HIS n 
1 287 PHE n 
1 288 LYS n 
1 289 ARG n 
1 290 LEU n 
1 291 TYR n 
1 292 GLY n 
1 293 LYS n 
1 294 SER n 
1 295 LEU n 
1 296 TYR n 
1 297 SER n 
1 298 PHE n 
1 299 ILE n 
1 300 LYS n 
1 301 GLY n 
1 302 ASP n 
1 303 THR n 
1 304 SER n 
1 305 GLY n 
1 306 ASP n 
1 307 TYR n 
1 308 ARG n 
1 309 LYS n 
1 310 VAL n 
1 311 LEU n 
1 312 LEU n 
1 313 VAL n 
1 314 LEU n 
1 315 CYS n 
1 316 GLY n 
1 317 GLY n 
1 318 ASP n 
1 319 ASP n 
1 320 HIS n 
1 321 HIS n 
1 322 HIS n 
1 323 HIS n 
1 324 HIS n 
1 325 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   325 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'ANXA4, ANX4' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'   ? 'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   LYS 4   4   4   LYS LYS A . n 
A 1 5   GLY 5   5   5   GLY GLY A . n 
A 1 6   GLY 6   6   6   GLY GLY A . n 
A 1 7   THR 7   7   7   THR THR A . n 
A 1 8   VAL 8   8   8   VAL VAL A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  SER 12  12  12  SER SER A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  PHE 14  14  14  PHE PHE A . n 
A 1 15  ASN 15  15  15  ASN ASN A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  ASP 19  19  19  ASP ASP A . n 
A 1 20  ALA 20  20  20  ALA ALA A . n 
A 1 21  GLN 21  21  21  GLN GLN A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  ARG 24  24  24  ARG ARG A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  MET 27  27  27  MET MET A . n 
A 1 28  LYS 28  28  28  LYS LYS A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  THR 32  32  32  THR THR A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  ILE 37  37  37  ILE ILE A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  VAL 40  40  40  VAL VAL A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  TYR 43  43  43  TYR TYR A . n 
A 1 44  ARG 44  44  44  ARG ARG A . n 
A 1 45  ASN 45  45  45  ASN ASN A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  ALA 47  47  47  ALA ALA A . n 
A 1 48  GLN 48  48  48  GLN GLN A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  GLN 50  50  50  GLN GLN A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  TYR 56  56  56  TYR TYR A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  THR 59  59  59  THR THR A . n 
A 1 60  ILE 60  60  60  ILE ILE A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  ARG 62  62  62  ARG ARG A . n 
A 1 63  ASP 63  63  63  ASP ASP A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  ASP 66  66  66  ASP ASP A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  PHE 76  76  76  PHE PHE A . n 
A 1 77  GLU 77  77  77  GLU GLU A . n 
A 1 78  GLN 78  78  78  GLN GLN A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  MET 84  84  84  MET MET A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  PRO 86  86  86  PRO PRO A . n 
A 1 87  THR 87  87  87  THR THR A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  TYR 90  90  90  TYR TYR A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  GLN 93  93  93  GLN GLN A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  MET 99  99  99  MET MET A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 ASP 105 105 105 ASP ASP A . n 
A 1 106 GLU 106 106 106 GLU GLU A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 CYS 108 108 108 CYS CYS A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 ILE 112 112 112 ILE ILE A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ALA 114 114 114 ALA ALA A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 GLU 120 120 120 GLU GLU A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 SER 125 125 125 SER SER A . n 
A 1 126 GLN 126 126 126 GLN GLN A . n 
A 1 127 THR 127 127 127 THR THR A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 GLN 129 129 129 GLN GLN A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 TYR 132 132 132 TYR TYR A . n 
A 1 133 GLY 133 133 133 GLY GLY A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 SER 135 135 135 SER SER A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 ASP 138 138 138 ASP ASP A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 ARG 141 141 141 ARG ARG A . n 
A 1 142 SER 142 142 142 SER SER A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 PHE 146 146 146 PHE PHE A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 PHE 148 148 148 PHE PHE A . n 
A 1 149 GLN 149 149 149 GLN GLN A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 GLY 158 158 158 GLY GLY A . n 
A 1 159 GLY 159 159 159 GLY GLY A . n 
A 1 160 ARG 160 160 160 ARG ARG A . n 
A 1 161 ASP 161 161 161 ASP ASP A . n 
A 1 162 GLU 162 162 162 GLU GLU A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ASN 164 164 164 ASN ASN A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 GLN 173 173 173 GLN GLN A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 TYR 179 179 179 TYR TYR A . n 
A 1 180 GLU 180 180 180 GLU GLU A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLY 182 182 182 GLY GLY A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 LYS 184 184 184 LYS LYS A . n 
A 1 185 LYS 185 185 185 LYS LYS A . n 
A 1 186 TRP 186 186 186 TRP TRP A . n 
A 1 187 GLY 187 187 187 GLY GLY A . n 
A 1 188 THR 188 188 188 THR THR A . n 
A 1 189 ASP 189 189 189 ASP ASP A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 LYS 192 192 192 LYS LYS A . n 
A 1 193 PHE 193 193 193 PHE PHE A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 LEU 197 197 197 LEU LEU A . n 
A 1 198 CYS 198 198 198 CYS CYS A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 ARG 200 200 200 ARG ARG A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 VAL 208 208 208 VAL VAL A . n 
A 1 209 PHE 209 209 209 PHE PHE A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLU 211 211 211 GLU GLU A . n 
A 1 212 TYR 212 212 212 TYR TYR A . n 
A 1 213 LYS 213 213 213 LYS LYS A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 GLN 217 217 217 GLN GLN A . n 
A 1 218 LYS 218 218 218 LYS LYS A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 ILE 220 220 220 ILE ILE A . n 
A 1 221 GLU 221 221 221 GLU GLU A . n 
A 1 222 GLN 222 222 222 GLN GLN A . n 
A 1 223 SER 223 223 223 SER SER A . n 
A 1 224 ILE 224 224 224 ILE ILE A . n 
A 1 225 LYS 225 225 225 LYS LYS A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 THR 228 228 228 THR THR A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 PHE 232 232 232 PHE PHE A . n 
A 1 233 GLU 233 233 233 GLU GLU A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 LYS 241 241 241 LYS LYS A . n 
A 1 242 CYS 242 242 242 CYS CYS A . n 
A 1 243 MET 243 243 243 MET MET A . n 
A 1 244 ARG 244 244 244 ARG ARG A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 LYS 246 246 246 LYS LYS A . n 
A 1 247 SER 247 247 247 SER SER A . n 
A 1 248 ALA 248 248 248 ALA ALA A . n 
A 1 249 TYR 249 249 249 TYR TYR A . n 
A 1 250 PHE 250 250 250 PHE PHE A . n 
A 1 251 ALA 251 251 251 ALA ALA A . n 
A 1 252 GLU 252 252 252 GLU GLU A . n 
A 1 253 LYS 253 253 253 LYS LYS A . n 
A 1 254 LEU 254 254 254 LEU LEU A . n 
A 1 255 TYR 255 255 255 TYR TYR A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 MET 258 258 258 MET MET A . n 
A 1 259 LYS 259 259 259 LYS LYS A . n 
A 1 260 GLY 260 260 260 GLY GLY A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 GLY 262 262 262 GLY GLY A . n 
A 1 263 THR 263 263 263 THR THR A . n 
A 1 264 ASP 264 264 264 ASP ASP A . n 
A 1 265 ASP 265 265 265 ASP ASP A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 VAL 271 271 271 VAL VAL A . n 
A 1 272 MET 272 272 272 MET MET A . n 
A 1 273 VAL 273 273 273 VAL VAL A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 GLU 277 277 277 GLU GLU A . n 
A 1 278 ILE 278 278 278 ILE ILE A . n 
A 1 279 ASP 279 279 279 ASP ASP A . n 
A 1 280 MET 280 280 280 MET MET A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ILE 283 283 283 ILE ILE A . n 
A 1 284 ARG 284 284 284 ARG ARG A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 HIS 286 286 286 HIS HIS A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 ARG 289 289 289 ARG ARG A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 TYR 291 291 291 TYR TYR A . n 
A 1 292 GLY 292 292 292 GLY GLY A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 SER 297 297 297 SER SER A . n 
A 1 298 PHE 298 298 298 PHE PHE A . n 
A 1 299 ILE 299 299 299 ILE ILE A . n 
A 1 300 LYS 300 300 300 LYS LYS A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 ASP 302 302 302 ASP ASP A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 GLY 305 305 305 GLY GLY A . n 
A 1 306 ASP 306 306 306 ASP ASP A . n 
A 1 307 TYR 307 307 307 TYR TYR A . n 
A 1 308 ARG 308 308 308 ARG ARG A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 VAL 310 310 310 VAL VAL A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 CYS 315 315 315 CYS CYS A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 ?   ?   ?   A . n 
A 1 321 HIS 321 321 ?   ?   ?   A . n 
A 1 322 HIS 322 322 ?   ?   ?   A . n 
A 1 323 HIS 323 323 ?   ?   ?   A . n 
A 1 324 HIS 324 324 ?   ?   ?   A . n 
A 1 325 HIS 325 325 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CA  ? ? CA  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 SO4 ? ? SO4 ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CA  1   401 1   CA  CA  A . 
C 2 CA  1   402 2   CA  CA  A . 
D 2 CA  1   403 4   CA  CA  A . 
E 3 SO4 1   404 239 SO4 SO4 A . 
F 3 SO4 1   405 240 SO4 SO4 A . 
G 3 SO4 1   406 241 SO4 SO4 A . 
H 3 SO4 1   407 244 SO4 SO4 A . 
I 4 HOH 1   501 144 HOH HOH A . 
I 4 HOH 2   502 103 HOH HOH A . 
I 4 HOH 3   503 127 HOH HOH A . 
I 4 HOH 4   504 100 HOH HOH A . 
I 4 HOH 5   505 97  HOH HOH A . 
I 4 HOH 6   506 113 HOH HOH A . 
I 4 HOH 7   507 146 HOH HOH A . 
I 4 HOH 8   508 78  HOH HOH A . 
I 4 HOH 9   509 31  HOH HOH A . 
I 4 HOH 10  510 188 HOH HOH A . 
I 4 HOH 11  511 118 HOH HOH A . 
I 4 HOH 12  512 117 HOH HOH A . 
I 4 HOH 13  513 58  HOH HOH A . 
I 4 HOH 14  514 108 HOH HOH A . 
I 4 HOH 15  515 77  HOH HOH A . 
I 4 HOH 16  516 149 HOH HOH A . 
I 4 HOH 17  517 26  HOH HOH A . 
I 4 HOH 18  518 76  HOH HOH A . 
I 4 HOH 19  519 125 HOH HOH A . 
I 4 HOH 20  520 94  HOH HOH A . 
I 4 HOH 21  521 37  HOH HOH A . 
I 4 HOH 22  522 164 HOH HOH A . 
I 4 HOH 23  523 59  HOH HOH A . 
I 4 HOH 24  524 92  HOH HOH A . 
I 4 HOH 25  525 36  HOH HOH A . 
I 4 HOH 26  526 104 HOH HOH A . 
I 4 HOH 27  527 61  HOH HOH A . 
I 4 HOH 28  528 53  HOH HOH A . 
I 4 HOH 29  529 200 HOH HOH A . 
I 4 HOH 30  530 87  HOH HOH A . 
I 4 HOH 31  531 214 HOH HOH A . 
I 4 HOH 32  532 69  HOH HOH A . 
I 4 HOH 33  533 5   HOH HOH A . 
I 4 HOH 34  534 34  HOH HOH A . 
I 4 HOH 35  535 102 HOH HOH A . 
I 4 HOH 36  536 141 HOH HOH A . 
I 4 HOH 37  537 85  HOH HOH A . 
I 4 HOH 38  538 22  HOH HOH A . 
I 4 HOH 39  539 101 HOH HOH A . 
I 4 HOH 40  540 83  HOH HOH A . 
I 4 HOH 41  541 126 HOH HOH A . 
I 4 HOH 42  542 51  HOH HOH A . 
I 4 HOH 43  543 18  HOH HOH A . 
I 4 HOH 44  544 11  HOH HOH A . 
I 4 HOH 45  545 213 HOH HOH A . 
I 4 HOH 46  546 140 HOH HOH A . 
I 4 HOH 47  547 161 HOH HOH A . 
I 4 HOH 48  548 9   HOH HOH A . 
I 4 HOH 49  549 179 HOH HOH A . 
I 4 HOH 50  550 75  HOH HOH A . 
I 4 HOH 51  551 66  HOH HOH A . 
I 4 HOH 52  552 183 HOH HOH A . 
I 4 HOH 53  553 136 HOH HOH A . 
I 4 HOH 54  554 20  HOH HOH A . 
I 4 HOH 55  555 16  HOH HOH A . 
I 4 HOH 56  556 79  HOH HOH A . 
I 4 HOH 57  557 187 HOH HOH A . 
I 4 HOH 58  558 173 HOH HOH A . 
I 4 HOH 59  559 35  HOH HOH A . 
I 4 HOH 60  560 64  HOH HOH A . 
I 4 HOH 61  561 10  HOH HOH A . 
I 4 HOH 62  562 56  HOH HOH A . 
I 4 HOH 63  563 152 HOH HOH A . 
I 4 HOH 64  564 52  HOH HOH A . 
I 4 HOH 65  565 42  HOH HOH A . 
I 4 HOH 66  566 50  HOH HOH A . 
I 4 HOH 67  567 13  HOH HOH A . 
I 4 HOH 68  568 131 HOH HOH A . 
I 4 HOH 69  569 84  HOH HOH A . 
I 4 HOH 70  570 71  HOH HOH A . 
I 4 HOH 71  571 8   HOH HOH A . 
I 4 HOH 72  572 105 HOH HOH A . 
I 4 HOH 73  573 95  HOH HOH A . 
I 4 HOH 74  574 99  HOH HOH A . 
I 4 HOH 75  575 91  HOH HOH A . 
I 4 HOH 76  576 199 HOH HOH A . 
I 4 HOH 77  577 6   HOH HOH A . 
I 4 HOH 78  578 39  HOH HOH A . 
I 4 HOH 79  579 123 HOH HOH A . 
I 4 HOH 80  580 19  HOH HOH A . 
I 4 HOH 81  581 60  HOH HOH A . 
I 4 HOH 82  582 29  HOH HOH A . 
I 4 HOH 83  583 139 HOH HOH A . 
I 4 HOH 84  584 47  HOH HOH A . 
I 4 HOH 85  585 70  HOH HOH A . 
I 4 HOH 86  586 4   HOH HOH A . 
I 4 HOH 87  587 28  HOH HOH A . 
I 4 HOH 88  588 134 HOH HOH A . 
I 4 HOH 89  589 73  HOH HOH A . 
I 4 HOH 90  590 96  HOH HOH A . 
I 4 HOH 91  591 65  HOH HOH A . 
I 4 HOH 92  592 17  HOH HOH A . 
I 4 HOH 93  593 159 HOH HOH A . 
I 4 HOH 94  594 137 HOH HOH A . 
I 4 HOH 95  595 124 HOH HOH A . 
I 4 HOH 96  596 15  HOH HOH A . 
I 4 HOH 97  597 12  HOH HOH A . 
I 4 HOH 98  598 133 HOH HOH A . 
I 4 HOH 99  599 33  HOH HOH A . 
I 4 HOH 100 600 182 HOH HOH A . 
I 4 HOH 101 601 215 HOH HOH A . 
I 4 HOH 102 602 82  HOH HOH A . 
I 4 HOH 103 603 116 HOH HOH A . 
I 4 HOH 104 604 98  HOH HOH A . 
I 4 HOH 105 605 197 HOH HOH A . 
I 4 HOH 106 606 57  HOH HOH A . 
I 4 HOH 107 607 160 HOH HOH A . 
I 4 HOH 108 608 185 HOH HOH A . 
I 4 HOH 109 609 150 HOH HOH A . 
I 4 HOH 110 610 25  HOH HOH A . 
I 4 HOH 111 611 132 HOH HOH A . 
I 4 HOH 112 612 68  HOH HOH A . 
I 4 HOH 113 613 174 HOH HOH A . 
I 4 HOH 114 614 80  HOH HOH A . 
I 4 HOH 115 615 119 HOH HOH A . 
I 4 HOH 116 616 154 HOH HOH A . 
I 4 HOH 117 617 48  HOH HOH A . 
I 4 HOH 118 618 86  HOH HOH A . 
I 4 HOH 119 619 23  HOH HOH A . 
I 4 HOH 120 620 40  HOH HOH A . 
I 4 HOH 121 621 81  HOH HOH A . 
I 4 HOH 122 622 106 HOH HOH A . 
I 4 HOH 123 623 90  HOH HOH A . 
I 4 HOH 124 624 54  HOH HOH A . 
I 4 HOH 125 625 315 HOH HOH A . 
I 4 HOH 126 626 176 HOH HOH A . 
I 4 HOH 127 627 157 HOH HOH A . 
I 4 HOH 128 628 162 HOH HOH A . 
I 4 HOH 129 629 122 HOH HOH A . 
I 4 HOH 130 630 72  HOH HOH A . 
I 4 HOH 131 631 147 HOH HOH A . 
I 4 HOH 132 632 129 HOH HOH A . 
I 4 HOH 133 633 32  HOH HOH A . 
I 4 HOH 134 634 130 HOH HOH A . 
I 4 HOH 135 635 44  HOH HOH A . 
I 4 HOH 136 636 38  HOH HOH A . 
I 4 HOH 137 637 145 HOH HOH A . 
I 4 HOH 138 638 89  HOH HOH A . 
I 4 HOH 139 639 63  HOH HOH A . 
I 4 HOH 140 640 201 HOH HOH A . 
I 4 HOH 141 641 43  HOH HOH A . 
I 4 HOH 142 642 175 HOH HOH A . 
I 4 HOH 143 643 27  HOH HOH A . 
I 4 HOH 144 644 24  HOH HOH A . 
I 4 HOH 145 645 155 HOH HOH A . 
I 4 HOH 146 646 180 HOH HOH A . 
I 4 HOH 147 647 67  HOH HOH A . 
I 4 HOH 148 648 41  HOH HOH A . 
I 4 HOH 149 649 49  HOH HOH A . 
I 4 HOH 150 650 143 HOH HOH A . 
I 4 HOH 151 651 151 HOH HOH A . 
I 4 HOH 152 652 120 HOH HOH A . 
I 4 HOH 153 653 142 HOH HOH A . 
I 4 HOH 154 654 88  HOH HOH A . 
I 4 HOH 155 655 74  HOH HOH A . 
I 4 HOH 156 656 30  HOH HOH A . 
I 4 HOH 157 657 111 HOH HOH A . 
I 4 HOH 158 658 114 HOH HOH A . 
I 4 HOH 159 659 186 HOH HOH A . 
I 4 HOH 160 660 181 HOH HOH A . 
I 4 HOH 161 661 93  HOH HOH A . 
I 4 HOH 162 662 172 HOH HOH A . 
I 4 HOH 163 663 110 HOH HOH A . 
I 4 HOH 164 664 128 HOH HOH A . 
I 4 HOH 165 665 62  HOH HOH A . 
I 4 HOH 166 666 109 HOH HOH A . 
I 4 HOH 167 667 112 HOH HOH A . 
I 4 HOH 168 668 121 HOH HOH A . 
I 4 HOH 169 669 189 HOH HOH A . 
I 4 HOH 170 670 202 HOH HOH A . 
I 4 HOH 171 671 168 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   95.141 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GA8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.613 
_cell.length_a_esd                 ? 
_cell.length_b                     39.620 
_cell.length_b_esd                 ? 
_cell.length_c                     73.496 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GA8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GA8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.38 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.29 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.6 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium acetate (pH 4.6), 0.2 M ammonium sulfate, and 25 % (v/v) PEG 4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.88560 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.88560 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9GA8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.5 
_reflns.d_resolution_low                               73.2 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     52824 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.037 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.50 
_reflns_shell.d_res_low                                     1.52 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2410 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.4 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.000 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            -0.001 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            0.001 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.672 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.960 
_refine.correlation_coeff_Fo_to_Fc_free          0.955 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GA8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.5 
_refine.ls_d_res_low                             58.377 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     52808 
_refine.ls_number_reflns_R_free                  2649 
_refine.ls_number_reflns_R_work                  50159 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.398 
_refine.ls_percent_reflns_R_free                 5.016 
_refine.ls_R_factor_all                          0.203 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2158 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2021 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.081 
_refine.pdbx_overall_ESU_R_Free                  0.077 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.715 
_refine.overall_SU_ML                            0.059 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.5 
_refine_hist.d_res_low                        58.377 
_refine_hist.number_atoms_solvent             171 
_refine_hist.number_atoms_total               2693 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2499 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         23 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.011  0.012  2544 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2438 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.896  1.839  3414 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.682  1.794  5606 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 5.848  5.000  316  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 7.543  5.000  24   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 12.734 10.000 487  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.098 10.000 122  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.095  0.200  382  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.010  0.020  3014 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  592  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.241  0.200  594  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.178  0.200  2199 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.186  0.200  1317 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.075  0.200  1390 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.131  0.200  140  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.074  0.200  11   ? r_metal_ion_refined            ? ? 
'X-RAY DIFFRACTION' ? 0.276  0.200  21   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.239  0.200  70   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.091  0.200  6    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.070  2.031  1267 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.017  2.033  1267 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 2.908  3.644  1582 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 2.918  3.646  1583 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.651  2.466  1277 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.553  2.431  1260 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.418  4.336  1832 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.345  4.284  1809 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 6.436  22.011 3051 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.370  21.399 3014 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.5   1.534  . . 171 3514 91.1227 . . . . 0.493 . . . . . . . . . . . 0.463 
'X-RAY DIFFRACTION' 1.534 1.576  . . 180 3623 97.1144 . . . . 0.446 . . . . . . . . . . . 0.467 
'X-RAY DIFFRACTION' 1.576 1.622  . . 204 3481 97.9532 . . . . 0.421 . . . . . . . . . . . 0.479 
'X-RAY DIFFRACTION' 1.622 1.672  . . 183 3499 98.3703 . . . . 0.338 . . . . . . . . . . . 0.375 
'X-RAY DIFFRACTION' 1.672 1.726  . . 172 3372 98.3625 . . . . 0.279 . . . . . . . . . . . 0.295 
'X-RAY DIFFRACTION' 1.726 1.787  . . 169 3219 98.4311 . . . . 0.245 . . . . . . . . . . . 0.270 
'X-RAY DIFFRACTION' 1.787 1.854  . . 146 3164 98.4533 . . . . 0.204 . . . . . . . . . . . 0.223 
'X-RAY DIFFRACTION' 1.854 1.930  . . 160 3001 98.0155 . . . . 0.191 . . . . . . . . . . . 0.215 
'X-RAY DIFFRACTION' 1.930 2.016  . . 152 2830 96.8496 . . . . 0.193 . . . . . . . . . . . 0.228 
'X-RAY DIFFRACTION' 2.016 2.114  . . 153 2699 95.6726 . . . . 0.188 . . . . . . . . . . . 0.221 
'X-RAY DIFFRACTION' 2.114 2.228  . . 151 2572 95.9817 . . . . 0.194 . . . . . . . . . . . 0.185 
'X-RAY DIFFRACTION' 2.228 2.363  . . 120 2506 97.6571 . . . . 0.173 . . . . . . . . . . . 0.187 
'X-RAY DIFFRACTION' 2.363 2.526  . . 135 2329 97.2376 . . . . 0.165 . . . . . . . . . . . 0.193 
'X-RAY DIFFRACTION' 2.526 2.728  . . 115 2143 96.8683 . . . . 0.160 . . . . . . . . . . . 0.166 
'X-RAY DIFFRACTION' 2.728 2.987  . . 102 1996 96.4598 . . . . 0.179 . . . . . . . . . . . 0.200 
'X-RAY DIFFRACTION' 2.987 3.339  . . 88  1795 95.4384 . . . . 0.170 . . . . . . . . . . . 0.189 
'X-RAY DIFFRACTION' 3.339 3.853  . . 87  1521 92.7336 . . . . 0.165 . . . . . . . . . . . 0.192 
'X-RAY DIFFRACTION' 3.853 4.714  . . 62  1315 92.4782 . . . . 0.160 . . . . . . . . . . . 0.158 
'X-RAY DIFFRACTION' 4.714 6.645  . . 75  1018 92.7844 . . . . 0.250 . . . . . . . . . . . 0.238 
'X-RAY DIFFRACTION' 6.645 58.377 . . 24  562  86.9436 . . . . 0.260 . . . . . . . . . . . 0.202 
# 
_struct.entry_id                     9GA8 
_struct.title                        'The crystal structure of human Annexin A4 from crystals grown at 4 mM Calcium' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GA8 
_struct_keywords.text            'Calcium/phospholipid-binding protein, complex with calcium, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ANXA4_HUMAN 
_struct_ref.pdbx_db_accession          P09525 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDD
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9GA8 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 319 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P09525 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  319 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       319 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9GA8 HIS A 320 ? UNP P09525 ? ? 'expression tag' 320 1 
1 9GA8 HIS A 321 ? UNP P09525 ? ? 'expression tag' 321 2 
1 9GA8 HIS A 322 ? UNP P09525 ? ? 'expression tag' 322 3 
1 9GA8 HIS A 323 ? UNP P09525 ? ? 'expression tag' 323 4 
1 9GA8 HIS A 324 ? UNP P09525 ? ? 'expression tag' 324 5 
1 9GA8 HIS A 325 ? UNP P09525 ? ? 'expression tag' 325 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 790   ? 
1 MORE         -69   ? 
1 'SSA (A^2)'  15190 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 15  ? LYS A 28  ? ASN A 15  LYS A 28  1 ? 14 
HELX_P HELX_P2  AA2 ASP A 33  ? ALA A 42  ? ASP A 33  ALA A 42  1 ? 10 
HELX_P HELX_P3  AA3 ASN A 45  ? GLY A 61  ? ASN A 45  GLY A 61  1 ? 17 
HELX_P HELX_P4  AA4 ASP A 63  ? LEU A 72  ? ASP A 63  LEU A 72  1 ? 10 
HELX_P HELX_P5  AA5 SER A 73  ? THR A 85  ? SER A 73  THR A 85  1 ? 13 
HELX_P HELX_P6  AA6 PRO A 86  ? LYS A 100 ? PRO A 86  LYS A 100 1 ? 15 
HELX_P HELX_P7  AA7 ASP A 105 ? ARG A 116 ? ASP A 105 ARG A 116 1 ? 12 
HELX_P HELX_P8  AA8 THR A 117 ? GLY A 133 ? THR A 117 GLY A 133 1 ? 17 
HELX_P HELX_P9  AA9 SER A 135 ? THR A 144 ? SER A 135 THR A 144 1 ? 10 
HELX_P HELX_P10 AB1 SER A 145 ? GLY A 158 ? SER A 145 GLY A 158 1 ? 14 
HELX_P HELX_P11 AB2 ASP A 167 ? GLY A 182 ? ASP A 167 GLY A 182 1 ? 16 
HELX_P HELX_P12 AB3 ASP A 189 ? ARG A 200 ? ASP A 189 ARG A 200 1 ? 12 
HELX_P HELX_P13 AB4 ASN A 201 ? GLN A 217 ? ASN A 201 GLN A 217 1 ? 17 
HELX_P HELX_P14 AB5 ASP A 219 ? THR A 228 ? ASP A 219 THR A 228 1 ? 10 
HELX_P HELX_P15 AB6 SER A 229 ? ASN A 245 ? SER A 229 ASN A 245 1 ? 17 
HELX_P HELX_P16 AB7 ASN A 245 ? GLY A 260 ? ASN A 245 GLY A 260 1 ? 16 
HELX_P HELX_P17 AB8 ASP A 264 ? ALA A 276 ? ASP A 264 ALA A 276 1 ? 13 
HELX_P HELX_P18 AB9 ASP A 279 ? GLY A 292 ? ASP A 279 GLY A 292 1 ? 14 
HELX_P HELX_P19 AC1 SER A 294 ? THR A 303 ? SER A 294 THR A 303 1 ? 10 
HELX_P HELX_P20 AC2 SER A 304 ? GLY A 316 ? SER A 304 GLY A 316 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A MET 27  O   ? ? ? 1_555 B CA  . CA ? ? A MET 27  A CA  401 1_555 ? ? ? ? ? ? ? 2.309 ? ? 
metalc2  metalc ? ? A GLY 29  O   ? ? ? 1_555 B CA  . CA ? ? A GLY 29  A CA  401 1_555 ? ? ? ? ? ? ? 2.365 ? ? 
metalc3  metalc ? ? A GLY 31  O   ? ? ? 1_555 B CA  . CA ? ? A GLY 31  A CA  401 1_555 ? ? ? ? ? ? ? 2.479 ? ? 
metalc4  metalc ? ? A GLU 71  OE1 ? ? ? 1_555 B CA  . CA ? ? A GLU 71  A CA  401 1_555 ? ? ? ? ? ? ? 2.558 ? ? 
metalc5  metalc ? ? A GLU 71  OE2 ? ? ? 1_555 B CA  . CA ? ? A GLU 71  A CA  401 1_555 ? ? ? ? ? ? ? 2.441 ? ? 
metalc6  metalc ? ? A MET 99  O   ? ? ? 1_555 C CA  . CA ? ? A MET 99  A CA  402 1_555 ? ? ? ? ? ? ? 2.465 ? ? 
metalc7  metalc ? ? A GLY 101 O   ? ? ? 1_555 C CA  . CA ? ? A GLY 101 A CA  402 1_555 ? ? ? ? ? ? ? 2.379 ? ? 
metalc8  metalc ? ? A GLY 103 O   ? ? ? 1_555 C CA  . CA ? ? A GLY 103 A CA  402 1_555 ? ? ? ? ? ? ? 2.419 ? ? 
metalc9  metalc ? ? A ASP 143 OD1 ? ? ? 1_555 C CA  . CA ? ? A ASP 143 A CA  402 1_555 ? ? ? ? ? ? ? 2.769 ? ? 
metalc10 metalc ? ? A ASP 143 OD2 ? ? ? 1_555 C CA  . CA ? ? A ASP 143 A CA  402 1_555 ? ? ? ? ? ? ? 2.479 ? ? 
metalc11 metalc ? ? A MET 258 O   ? ? ? 1_555 D CA  . CA ? ? A MET 258 A CA  403 1_555 ? ? ? ? ? ? ? 2.292 ? ? 
metalc12 metalc ? ? A GLY 260 O   ? ? ? 1_555 D CA  . CA ? ? A GLY 260 A CA  403 1_555 ? ? ? ? ? ? ? 2.506 ? ? 
metalc13 metalc ? ? A GLY 262 O   ? ? ? 1_555 D CA  . CA ? ? A GLY 262 A CA  403 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc14 metalc ? ? A ASP 302 OD1 ? ? ? 1_555 D CA  . CA ? ? A ASP 302 A CA  403 1_555 ? ? ? ? ? ? ? 2.604 ? ? 
metalc15 metalc ? ? A ASP 302 OD2 ? ? ? 1_555 D CA  . CA ? ? A ASP 302 A CA  403 1_555 ? ? ? ? ? ? ? 2.403 ? ? 
metalc16 metalc ? ? B CA  .   CA  ? ? ? 1_555 I HOH . O  ? ? A CA  401 A HOH 625 1_555 ? ? ? ? ? ? ? 2.409 ? ? 
metalc17 metalc ? ? B CA  .   CA  ? ? ? 1_555 I HOH . O  ? ? A CA  401 A HOH 654 1_555 ? ? ? ? ? ? ? 2.336 ? ? 
metalc18 metalc ? ? D CA  .   CA  ? ? ? 1_555 I HOH . O  ? ? A CA  403 A HOH 601 1_555 ? ? ? ? ? ? ? 2.326 ? ? 
metalc19 metalc ? ? D CA  .   CA  ? ? ? 1_555 I HOH . O  ? ? A CA  403 A HOH 653 1_555 ? ? ? ? ? ? ? 2.331 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 29  ? A GLY 29  ? 1_555 87.7  ? 
2  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 31  ? A GLY 31  ? 1_555 96.2  ? 
3  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 31  ? A GLY 31  ? 1_555 79.4  ? 
4  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 85.0  ? 
5  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 155.8 ? 
6  O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 78.4  ? 
7  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 82.7  ? 
8  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 149.4 ? 
9  O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 130.4 ? 
10 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 52.0  ? 
11 O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 625 ? 1_555 93.8  ? 
12 O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 625 ? 1_555 77.2  ? 
13 O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 625 ? 1_555 154.1 ? 
14 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 625 ? 1_555 126.3 ? 
15 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 625 ? 1_555 74.6  ? 
16 O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 173.7 ? 
17 O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 98.6  ? 
18 O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 84.2  ? 
19 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 88.9  ? 
20 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 92.2  ? 
21 O   ? I HOH .   ? A HOH 625 ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? I HOH .   ? A HOH 654 ? 1_555 88.5  ? 
22 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 101 ? A GLY 101 ? 1_555 84.3  ? 
23 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 103 ? A GLY 103 ? 1_555 102.5 ? 
24 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 103 ? A GLY 103 ? 1_555 90.1  ? 
25 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD1 ? A ASP 143 ? A ASP 143 ? 1_555 89.1  ? 
26 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD1 ? A ASP 143 ? A ASP 143 ? 1_555 137.6 ? 
27 O   ? A GLY 103 ? A GLY 103 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD1 ? A ASP 143 ? A ASP 143 ? 1_555 132.1 ? 
28 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 89.9  ? 
29 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 169.8 ? 
30 O   ? A GLY 103 ? A GLY 103 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 83.0  ? 
31 OD1 ? A ASP 143 ? A ASP 143 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 50.3  ? 
32 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 260 ? A GLY 260 ? 1_555 85.1  ? 
33 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 262 ? A GLY 262 ? 1_555 102.3 ? 
34 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 262 ? A GLY 262 ? 1_555 86.5  ? 
35 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 92.5  ? 
36 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 145.2 ? 
37 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 127.7 ? 
38 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 81.8  ? 
39 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 159.6 ? 
40 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 81.1  ? 
41 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 51.5  ? 
42 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 601 ? 1_555 97.1  ? 
43 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 601 ? 1_555 75.1  ? 
44 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 601 ? 1_555 151.9 ? 
45 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 601 ? 1_555 70.8  ? 
46 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 601 ? 1_555 122.0 ? 
47 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 170.5 ? 
48 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 103.1 ? 
49 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 83.2  ? 
50 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 78.0  ? 
51 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 91.5  ? 
52 O   ? I HOH .   ? A HOH 601 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? I HOH .   ? A HOH 653 ? 1_555 80.6  ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           317 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            317 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   ASP 
_struct_mon_prot_cis.pdbx_label_seq_id_2    318 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    ASP 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     318 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -11.66 
# 
_pdbx_entry_details.entry_id                   9GA8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 24  ? ? CZ A ARG 24  ? ? NH2 A ARG 24  ? ? 116.74 120.30 -3.56 0.50 N 
2 1 NE A ARG 97  ? ? CZ A ARG 97  ? ? NH2 A ARG 97  ? ? 116.39 120.30 -3.91 0.50 N 
3 1 NE A ARG 116 ? ? CZ A ARG 116 ? ? NH1 A ARG 116 ? ? 123.33 120.30 3.03  0.50 N 
4 1 CG A MET 147 ? ? SD A MET 147 ? ? CE  A MET 147 ? ? 112.00 100.20 11.80 1.60 N 
5 1 NE A ARG 200 ? ? CZ A ARG 200 ? ? NH2 A ARG 200 ? ? 116.87 120.30 -3.43 0.50 N 
6 1 CD A LYS 253 ? ? CE A LYS 253 ? ? NZ  A LYS 253 ? ? 131.20 111.70 19.50 2.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 146 ? ? 59.76   -137.80 
2 1 ASN A 245 ? ? -167.53 101.79  
3 1 ILE A 278 ? ? -100.40 -60.84  
4 1 ASP A 279 ? ? -150.85 26.86   
5 1 ASP A 318 ? ? -169.03 51.08   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1   ? A MET 1   
2 1 Y 1 A ALA 2   ? A ALA 2   
3 1 Y 1 A HIS 320 ? A HIS 320 
4 1 Y 1 A HIS 321 ? A HIS 321 
5 1 Y 1 A HIS 322 ? A HIS 322 
6 1 Y 1 A HIS 323 ? A HIS 323 
7 1 Y 1 A HIS 324 ? A HIS 324 
8 1 Y 1 A HIS 325 ? A HIS 325 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
SO4 S    S  N N 305 
SO4 O1   O  N N 306 
SO4 O2   O  N N 307 
SO4 O3   O  N N 308 
SO4 O4   O  N N 309 
THR N    N  N N 310 
THR CA   C  N S 311 
THR C    C  N N 312 
THR O    O  N N 313 
THR CB   C  N R 314 
THR OG1  O  N N 315 
THR CG2  C  N N 316 
THR OXT  O  N N 317 
THR H    H  N N 318 
THR H2   H  N N 319 
THR HA   H  N N 320 
THR HB   H  N N 321 
THR HG1  H  N N 322 
THR HG21 H  N N 323 
THR HG22 H  N N 324 
THR HG23 H  N N 325 
THR HXT  H  N N 326 
TRP N    N  N N 327 
TRP CA   C  N S 328 
TRP C    C  N N 329 
TRP O    O  N N 330 
TRP CB   C  N N 331 
TRP CG   C  Y N 332 
TRP CD1  C  Y N 333 
TRP CD2  C  Y N 334 
TRP NE1  N  Y N 335 
TRP CE2  C  Y N 336 
TRP CE3  C  Y N 337 
TRP CZ2  C  Y N 338 
TRP CZ3  C  Y N 339 
TRP CH2  C  Y N 340 
TRP OXT  O  N N 341 
TRP H    H  N N 342 
TRP H2   H  N N 343 
TRP HA   H  N N 344 
TRP HB2  H  N N 345 
TRP HB3  H  N N 346 
TRP HD1  H  N N 347 
TRP HE1  H  N N 348 
TRP HE3  H  N N 349 
TRP HZ2  H  N N 350 
TRP HZ3  H  N N 351 
TRP HH2  H  N N 352 
TRP HXT  H  N N 353 
TYR N    N  N N 354 
TYR CA   C  N S 355 
TYR C    C  N N 356 
TYR O    O  N N 357 
TYR CB   C  N N 358 
TYR CG   C  Y N 359 
TYR CD1  C  Y N 360 
TYR CD2  C  Y N 361 
TYR CE1  C  Y N 362 
TYR CE2  C  Y N 363 
TYR CZ   C  Y N 364 
TYR OH   O  N N 365 
TYR OXT  O  N N 366 
TYR H    H  N N 367 
TYR H2   H  N N 368 
TYR HA   H  N N 369 
TYR HB2  H  N N 370 
TYR HB3  H  N N 371 
TYR HD1  H  N N 372 
TYR HD2  H  N N 373 
TYR HE1  H  N N 374 
TYR HE2  H  N N 375 
TYR HH   H  N N 376 
TYR HXT  H  N N 377 
VAL N    N  N N 378 
VAL CA   C  N S 379 
VAL C    C  N N 380 
VAL O    O  N N 381 
VAL CB   C  N N 382 
VAL CG1  C  N N 383 
VAL CG2  C  N N 384 
VAL OXT  O  N N 385 
VAL H    H  N N 386 
VAL H2   H  N N 387 
VAL HA   H  N N 388 
VAL HB   H  N N 389 
VAL HG11 H  N N 390 
VAL HG12 H  N N 391 
VAL HG13 H  N N 392 
VAL HG21 H  N N 393 
VAL HG22 H  N N 394 
VAL HG23 H  N N 395 
VAL HXT  H  N N 396 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
SO4 S   O1   doub N N 290 
SO4 S   O2   doub N N 291 
SO4 S   O3   sing N N 292 
SO4 S   O4   sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2ZOC 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_related_exp_data_set.ordinal              1 
_pdbx_related_exp_data_set.data_reference       10.15151/ESRF-ES-541045740 
_pdbx_related_exp_data_set.metadata_reference   ? 
_pdbx_related_exp_data_set.data_set_type        'diffraction image data' 
_pdbx_related_exp_data_set.details              ? 
# 
_atom_sites.entry_id                    9GA8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017061 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001535 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.025240 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013661 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512  0.2156   
CA 20 20 8.6266  10.4421 7.3873 0.6599  1.5899 85.7484 1.0211 178.4370 1.6375   
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997  0.0030   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826   -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089  0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720  1.0220   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N   . THR A 1 3   ? 38.791 25.749  47.650 1.000 52.738 0 3   THR A N   1 ? 
ATOM   2    C  CA  . THR A 1 3   ? 39.051 27.151  47.239 1.000 49.952 0 3   THR A CA  1 ? 
ATOM   3    C  C   . THR A 1 3   ? 39.893 27.205  45.949 1.000 43.876 0 3   THR A C   1 ? 
ATOM   4    O  O   . THR A 1 3   ? 39.555 27.991  45.073 1.000 45.018 0 3   THR A O   1 ? 
ATOM   5    C  CB  . THR A 1 3   ? 39.593 27.980  48.413 1.000 52.698 0 3   THR A CB  1 ? 
ATOM   6    O  OG1 . THR A 1 3   ? 40.783 28.645  47.992 1.000 53.346 0 3   THR A OG1 1 ? 
ATOM   7    C  CG2 . THR A 1 3   ? 39.930 27.162  49.649 1.000 57.479 0 3   THR A CG2 1 ? 
ATOM   8    N  N   . LYS A 1 4   ? 40.943 26.374  45.770 1.000 32.140 0 4   LYS A N   1 ? 
ATOM   9    C  CA  . LYS A 1 4   ? 41.577 26.242  44.463 1.000 28.839 0 4   LYS A CA  1 ? 
ATOM   10   C  C   . LYS A 1 4   ? 40.888 25.161  43.603 1.000 27.405 0 4   LYS A C   1 ? 
ATOM   11   O  O   . LYS A 1 4   ? 40.945 25.227  42.363 1.000 27.381 0 4   LYS A O   1 ? 
ATOM   12   C  CB  . LYS A 1 4   ? 43.078 25.929  44.542 1.000 34.631 0 4   LYS A CB  1 ? 
ATOM   13   C  CG  . LYS A 1 4   ? 44.009 26.878  45.311 1.000 37.834 0 4   LYS A CG  1 ? 
ATOM   14   C  CD  . LYS A 1 4   ? 45.399 26.261  45.472 1.000 39.499 0 4   LYS A CD  1 ? 
ATOM   15   C  CE  . LYS A 1 4   ? 46.384 27.080  46.246 1.000 46.628 0 4   LYS A CE  1 ? 
ATOM   16   N  NZ  . LYS A 1 4   ? 45.951 27.241  47.638 1.000 50.310 0 4   LYS A NZ  1 ? 
ATOM   17   N  N   . GLY A 1 5   ? 40.360 24.101  44.235 1.000 22.611 0 5   GLY A N   1 ? 
ATOM   18   C  CA  . GLY A 1 5   ? 39.613 23.063  43.537 1.000 20.926 0 5   GLY A CA  1 ? 
ATOM   19   C  C   . GLY A 1 5   ? 40.499 21.901  43.024 1.000 20.491 0 5   GLY A C   1 ? 
ATOM   20   O  O   . GLY A 1 5   ? 41.576 21.641  43.575 1.000 21.658 0 5   GLY A O   1 ? 
ATOM   21   N  N   . GLY A 1 6   ? 40.016 21.228  41.967 1.000 19.733 0 6   GLY A N   1 ? 
ATOM   22   C  CA  . GLY A 1 6   ? 40.576 19.970  41.501 1.000 21.167 0 6   GLY A CA  1 ? 
ATOM   23   C  C   . GLY A 1 6   ? 41.631 20.132  40.414 1.000 19.227 0 6   GLY A C   1 ? 
ATOM   24   O  O   . GLY A 1 6   ? 41.748 21.190  39.778 1.000 20.600 0 6   GLY A O   1 ? 
ATOM   25   N  N   . THR A 1 7   ? 42.371 19.055  40.157 1.000 17.776 0 7   THR A N   1 ? 
ATOM   26   C  CA  . THR A 1 7   ? 43.282 19.019  39.024 1.000 17.385 0 7   THR A CA  1 ? 
ATOM   27   C  C   . THR A 1 7   ? 42.567 18.563  37.751 1.000 20.343 0 7   THR A C   1 ? 
ATOM   28   O  O   . THR A 1 7   ? 42.887 19.024  36.675 1.000 23.102 0 7   THR A O   1 ? 
ATOM   29   C  CB  . THR A 1 7   ? 44.452 18.112  39.366 1.000 18.864 0 7   THR A CB  1 ? 
ATOM   30   O  OG1 . THR A 1 7   ? 43.865 16.908  39.829 1.000 21.450 0 7   THR A OG1 1 ? 
ATOM   31   C  CG2 . THR A 1 7   ? 45.258 18.637  40.538 1.000 17.440 0 7   THR A CG2 1 ? 
ATOM   32   N  N   . VAL A 1 8   ? 41.688 17.578  37.876 1.000 19.762 0 8   VAL A N   1 ? 
ATOM   33   C  CA  . VAL A 1 8   ? 41.061 16.950  36.728 1.000 18.471 0 8   VAL A CA  1 ? 
ATOM   34   C  C   . VAL A 1 8   ? 39.813 17.757  36.432 1.000 20.576 0 8   VAL A C   1 ? 
ATOM   35   O  O   . VAL A 1 8   ? 38.946 17.908  37.299 1.000 23.076 0 8   VAL A O   1 ? 
ATOM   36   C  CB  . VAL A 1 8   ? 40.704 15.468  36.998 1.000 20.483 0 8   VAL A CB  1 ? 
ATOM   37   C  CG1 . VAL A 1 8   ? 39.866 14.886  35.886 1.000 21.373 0 8   VAL A CG1 1 ? 
ATOM   38   C  CG2 . VAL A 1 8   ? 41.965 14.641  37.167 1.000 21.069 0 8   VAL A CG2 1 ? 
ATOM   39   N  N   . LYS A 1 9   ? 39.697 18.244  35.190 1.000 23.513 0 9   LYS A N   1 ? 
ATOM   40   C  CA  . LYS A 1 9   ? 38.531 18.983  34.759 1.000 25.279 0 9   LYS A CA  1 ? 
ATOM   41   C  C   . LYS A 1 9   ? 37.950 18.334  33.505 1.000 25.082 0 9   LYS A C   1 ? 
ATOM   42   O  O   . LYS A 1 9   ? 38.593 17.478  32.855 1.000 21.946 0 9   LYS A O   1 ? 
ATOM   43   C  CB  . LYS A 1 9   ? 39.003 20.419  34.511 1.000 33.834 0 9   LYS A CB  1 ? 
ATOM   44   C  CG  . LYS A 1 9   ? 39.302 21.218  35.805 1.000 38.691 0 9   LYS A CG  1 ? 
ATOM   45   C  CD  . LYS A 1 9   ? 38.420 22.446  36.016 1.000 46.523 0 9   LYS A CD  1 ? 
ATOM   46   C  CE  . LYS A 1 9   ? 38.163 22.846  37.443 1.000 51.263 0 9   LYS A CE  1 ? 
ATOM   47   N  NZ  . LYS A 1 9   ? 39.390 22.844  38.232 1.000 49.530 0 9   LYS A NZ  1 ? 
ATOM   48   N  N   . ALA A 1 10  ? 36.724 18.756  33.184 1.000 23.669 0 10  ALA A N   1 ? 
ATOM   49   C  CA  . ALA A 1 10  ? 36.074 18.311  31.955 1.000 22.831 0 10  ALA A CA  1 ? 
ATOM   50   C  C   . ALA A 1 10  ? 36.940 18.752  30.783 1.000 23.652 0 10  ALA A C   1 ? 
ATOM   51   O  O   . ALA A 1 10  ? 37.373 19.911  30.741 1.000 22.581 0 10  ALA A O   1 ? 
ATOM   52   C  CB  . ALA A 1 10  ? 34.685 18.868  31.877 1.000 27.657 0 10  ALA A CB  1 ? 
ATOM   53   N  N   . ALA A 1 11  ? 37.166 17.845  29.823 1.000 20.544 0 11  ALA A N   1 ? 
ATOM   54   C  CA  . ALA A 1 11  ? 38.003 18.134  28.675 1.000 20.828 0 11  ALA A CA  1 ? 
ATOM   55   C  C   . ALA A 1 11  ? 37.193 18.977  27.720 1.000 20.540 0 11  ALA A C   1 ? 
ATOM   56   O  O   . ALA A 1 11  ? 36.002 18.743  27.584 1.000 23.843 0 11  ALA A O   1 ? 
ATOM   57   C  CB  . ALA A 1 11  ? 38.436 16.914  27.918 1.000 19.783 0 11  ALA A CB  1 ? 
ATOM   58   N  N   . SER A 1 12  ? 37.904 19.900  27.056 1.000 24.537 0 12  SER A N   1 ? 
ATOM   59   C  CA  . SER A 1 12  ? 37.385 20.536  25.862 1.000 28.761 0 12  SER A CA  1 ? 
ATOM   60   C  C   . SER A 1 12  ? 37.671 19.642  24.648 1.000 25.591 0 12  SER A C   1 ? 
ATOM   61   O  O   . SER A 1 12  ? 38.569 18.787  24.655 1.000 29.686 0 12  SER A O   1 ? 
ATOM   62   C  CB  . SER A 1 12  ? 38.028 21.935  25.743 1.000 29.722 0 12  SER A CB  1 ? 
ATOM   63   O  OG  . SER A 1 12  ? 39.420 21.750  25.549 1.000 33.504 0 12  SER A OG  1 ? 
ATOM   64   N  N   . GLY A 1 13  ? 36.847 19.777  23.620 1.000 24.245 0 13  GLY A N   1 ? 
ATOM   65   C  CA  . GLY A 1 13  ? 37.012 19.024  22.397 1.000 21.872 0 13  GLY A CA  1 ? 
ATOM   66   C  C   . GLY A 1 13  ? 36.742 17.545  22.625 1.000 20.111 0 13  GLY A C   1 ? 
ATOM   67   O  O   . GLY A 1 13  ? 37.113 16.737  21.793 1.000 21.215 0 13  GLY A O   1 ? 
ATOM   68   N  N   . PHE A 1 14  ? 36.016 17.229  23.701 1.000 19.060 0 14  PHE A N   1 ? 
ATOM   69   C  CA  . PHE A 1 14  ? 35.789 15.823  24.032 1.000 17.671 0 14  PHE A CA  1 ? 
ATOM   70   C  C   . PHE A 1 14  ? 35.036 15.133  22.909 1.000 17.602 0 14  PHE A C   1 ? 
ATOM   71   O  O   . PHE A 1 14  ? 33.913 15.513  22.609 1.000 18.333 0 14  PHE A O   1 ? 
ATOM   72   C  CB  . PHE A 1 14  ? 34.992 15.789  25.331 1.000 17.884 0 14  PHE A CB  1 ? 
ATOM   73   C  CG  . PHE A 1 14  ? 34.491 14.443  25.791 1.000 15.712 0 14  PHE A CG  1 ? 
ATOM   74   C  CD1 . PHE A 1 14  ? 35.231 13.268  25.568 1.000 16.495 0 14  PHE A CD1 1 ? 
ATOM   75   C  CD2 . PHE A 1 14  ? 33.252 14.350  26.404 1.000 15.521 0 14  PHE A CD2 1 ? 
ATOM   76   C  CE1 . PHE A 1 14  ? 34.692 12.063  25.968 1.000 14.231 0 14  PHE A CE1 1 ? 
ATOM   77   C  CE2 . PHE A 1 14  ? 32.744 13.151  26.804 1.000 15.560 0 14  PHE A CE2 1 ? 
ATOM   78   C  CZ  . PHE A 1 14  ? 33.498 12.010  26.651 1.000 14.522 0 14  PHE A CZ  1 ? 
ATOM   79   N  N   . ASN A 1 15  ? 35.612 14.024  22.381 1.000 15.299 0 15  ASN A N   1 ? 
ATOM   80   C  CA  . ASN A 1 15  ? 34.946 13.255  21.338 1.000 17.490 0 15  ASN A CA  1 ? 
ATOM   81   C  C   . ASN A 1 15  ? 34.927 11.788  21.780 1.000 16.275 0 15  ASN A C   1 ? 
ATOM   82   O  O   . ASN A 1 15  ? 35.978 11.196  21.794 1.000 16.986 0 15  ASN A O   1 ? 
ATOM   83   C  CB  . ASN A 1 15  ? 35.683 13.486  20.029 1.000 22.204 0 15  ASN A CB  1 ? 
ATOM   84   C  CG  . ASN A 1 15  ? 35.202 12.651  18.875 1.000 25.726 0 15  ASN A CG  1 ? 
ATOM   85   O  OD1 . ASN A 1 15  ? 34.487 11.657  19.017 1.000 21.441 0 15  ASN A OD1 1 ? 
ATOM   86   N  ND2 . ASN A 1 15  ? 35.675 13.038  17.699 1.000 34.785 0 15  ASN A ND2 1 ? 
ATOM   87   N  N   . ALA A 1 16  ? 33.795 11.365  22.327 1.000 15.922 0 16  ALA A N   1 ? 
ATOM   88   C  CA  . ALA A 1 16  ? 33.724 10.047  22.976 1.000 14.074 0 16  ALA A CA  1 ? 
ATOM   89   C  C   . ALA A 1 16  ? 34.045 8.926   21.997 1.000 16.322 0 16  ALA A C   1 ? 
ATOM   90   O  O   . ALA A 1 16  ? 34.669 7.944   22.399 1.000 15.023 0 16  ALA A O   1 ? 
ATOM   91   C  CB  . ALA A 1 16  ? 32.424 9.865   23.694 1.000 14.892 0 16  ALA A CB  1 ? 
ATOM   92   N  N   . MET A 1 17  ? 33.610 9.055   20.745 1.000 17.123 0 17  MET A N   1 ? 
ATOM   93   C  CA  . MET A 1 17  ? 33.849 8.015   19.776 1.000 18.345 0 17  MET A CA  1 ? 
ATOM   94   C  C   . MET A 1 17  ? 35.331 7.928   19.440 1.000 19.113 0 17  MET A C   1 ? 
ATOM   95   O  O   . MET A 1 17  ? 35.872 6.824   19.324 1.000 18.167 0 17  MET A O   1 ? 
ATOM   96   C  CB  . MET A 1 17  ? 33.044 8.235   18.480 1.000 19.919 0 17  MET A CB  1 ? 
ATOM   97   C  CG  . MET A 1 17  ? 31.558 7.906   18.689 1.000 24.981 0 17  MET A CG  1 ? 
ATOM   98   S  SD  . MET A 1 17  ? 30.568 7.948   17.170 1.000 34.274 0 17  MET A SD  1 ? 
ATOM   99   C  CE  . MET A 1 17  ? 31.762 7.537   15.915 1.000 27.326 0 17  MET A CE  1 ? 
ATOM   100  N  N   . GLU A 1 18  ? 36.011 9.078   19.312 1.000 17.882 0 18  GLU A N   1 ? 
ATOM   101  C  CA  . GLU A 1 18  ? 37.424 9.104   19.049 1.000 17.223 0 18  GLU A CA  1 ? 
ATOM   102  C  C   . GLU A 1 18  ? 38.192 8.503   20.234 1.000 15.260 0 18  GLU A C   1 ? 
ATOM   103  O  O   . GLU A 1 18  ? 39.120 7.751   20.031 1.000 17.728 0 18  GLU A O   1 ? 
ATOM   104  C  CB  . GLU A 1 18  ? 37.957 10.515  18.786 1.000 21.016 0 18  GLU A CB  1 ? 
ATOM   105  C  CG  . GLU A 1 18  ? 39.453 10.511  18.444 1.000 28.252 0 18  GLU A CG  1 ? 
ATOM   106  C  CD  . GLU A 1 18  ? 40.277 11.807  18.534 1.000 36.794 0 18  GLU A CD  1 ? 
ATOM   107  O  OE1 . GLU A 1 18  ? 40.401 12.386  17.445 1.000 42.378 0 18  GLU A OE1 1 ? 
ATOM   108  O  OE2 . GLU A 1 18  ? 40.855 12.213  19.588 1.000 36.537 0 18  GLU A OE2 1 ? 
ATOM   109  N  N   . ASP A 1 19  ? 37.766 8.834   21.447 1.000 13.899 0 19  ASP A N   1 ? 
ATOM   110  C  CA  . ASP A 1 19  ? 38.393 8.308   22.648 1.000 14.183 0 19  ASP A CA  1 ? 
ATOM   111  C  C   . ASP A 1 19  ? 38.226 6.802   22.692 1.000 15.680 0 19  ASP A C   1 ? 
ATOM   112  O  O   . ASP A 1 19  ? 39.211 6.111   23.003 1.000 14.925 0 19  ASP A O   1 ? 
ATOM   113  C  CB  . ASP A 1 19  ? 37.821 8.921   23.910 1.000 13.147 0 19  ASP A CB  1 ? 
ATOM   114  C  CG  . ASP A 1 19  ? 38.218 10.386  24.164 1.000 14.671 0 19  ASP A CG  1 ? 
ATOM   115  O  OD1 . ASP A 1 19  ? 39.100 10.881  23.453 1.000 17.491 0 19  ASP A OD1 1 ? 
ATOM   116  O  OD2 . ASP A 1 19  ? 37.670 10.984  25.095 1.000 18.891 0 19  ASP A OD2 1 ? 
ATOM   117  N  N   . ALA A 1 20  ? 37.014 6.325   22.368 1.000 13.940 0 20  ALA A N   1 ? 
ATOM   118  C  CA  . ALA A 1 20  ? 36.764 4.879   22.263 1.000 14.877 0 20  ALA A CA  1 ? 
ATOM   119  C  C   . ALA A 1 20  ? 37.748 4.240   21.287 1.000 15.957 0 20  ALA A C   1 ? 
ATOM   120  O  O   . ALA A 1 20  ? 38.333 3.193   21.582 1.000 15.287 0 20  ALA A O   1 ? 
ATOM   121  C  CB  . ALA A 1 20  ? 35.350 4.522   21.894 1.000 16.652 0 20  ALA A CB  1 ? 
ATOM   122  N  N   . GLN A 1 21  ? 37.931 4.849   20.110 1.000 14.925 0 21  GLN A N   1 ? 
ATOM   123  C  CA  . GLN A 1 21  ? 38.855 4.297   19.147 1.000 17.225 0 21  GLN A CA  1 ? 
ATOM   124  C  C   . GLN A 1 21  ? 40.318 4.334   19.652 1.000 16.774 0 21  GLN A C   1 ? 
ATOM   125  O  O   . GLN A 1 21  ? 41.055 3.360   19.440 1.000 15.966 0 21  GLN A O   1 ? 
ATOM   126  C  CB  . GLN A 1 21  ? 38.697 4.962   17.779 1.000 19.562 0 21  GLN A CB  1 ? 
ATOM   127  C  CG  . GLN A 1 21  ? 39.628 4.293   16.757 1.000 33.049 0 21  GLN A CG  1 ? 
ATOM   128  C  CD  . GLN A 1 21  ? 39.483 2.769   16.636 1.000 44.764 0 21  GLN A CD  1 ? 
ATOM   129  O  OE1 . GLN A 1 21  ? 40.357 1.944   17.018 1.000 38.451 0 21  GLN A OE1 1 ? 
ATOM   130  N  NE2 . GLN A 1 21  ? 38.336 2.366   16.096 1.000 44.483 0 21  GLN A NE2 1 ? 
ATOM   131  N  N   . THR A 1 22  ? 40.749 5.406   20.325 1.000 14.620 0 22  THR A N   1 ? 
ATOM   132  C  CA  . THR A 1 22  ? 42.083 5.500   20.893 1.000 16.340 0 22  THR A CA  1 ? 
ATOM   133  C  C   . THR A 1 22  ? 42.302 4.367   21.884 1.000 16.752 0 22  THR A C   1 ? 
ATOM   134  O  O   . THR A 1 22  ? 43.335 3.727   21.860 1.000 15.322 0 22  THR A O   1 ? 
ATOM   135  C  CB  . THR A 1 22  ? 42.270 6.870   21.536 1.000 16.182 0 22  THR A CB  1 ? 
ATOM   136  O  OG1 . THR A 1 22  ? 42.150 7.831   20.480 1.000 17.989 0 22  THR A OG1 1 ? 
ATOM   137  C  CG2 . THR A 1 22  ? 43.633 6.978   22.182 1.000 15.853 0 22  THR A CG2 1 ? 
ATOM   138  N  N   . LEU A 1 23  ? 41.294 4.106   22.733 1.000 15.234 0 23  LEU A N   1 ? 
ATOM   139  C  CA  . LEU A 1 23  ? 41.496 3.082   23.751 1.000 13.820 0 23  LEU A CA  1 ? 
ATOM   140  C  C   . LEU A 1 23  ? 41.546 1.680   23.159 1.000 14.440 0 23  LEU A C   1 ? 
ATOM   141  O  O   . LEU A 1 23  ? 42.401 0.863   23.592 1.000 16.219 0 23  LEU A O   1 ? 
ATOM   142  C  CB  . LEU A 1 23  ? 40.369 3.253   24.787 1.000 13.252 0 23  LEU A CB  1 ? 
ATOM   143  C  CG  . LEU A 1 23  ? 40.524 4.502   25.674 1.000 14.519 0 23  LEU A CG  1 ? 
ATOM   144  C  CD1 . LEU A 1 23  ? 39.188 4.765   26.345 1.000 13.989 0 23  LEU A CD1 1 ? 
ATOM   145  C  CD2 . LEU A 1 23  ? 41.558 4.379   26.725 1.000 16.253 0 23  LEU A CD2 1 ? 
ATOM   146  N  N   . ARG A 1 24  ? 40.706 1.444   22.154 1.000 15.223 0 24  ARG A N   1 ? 
ATOM   147  C  CA  . ARG A 1 24  ? 40.723 0.131   21.529 1.000 15.783 0 24  ARG A CA  1 ? 
ATOM   148  C  C   . ARG A 1 24  ? 42.082 -0.057  20.849 1.000 14.164 0 24  ARG A C   1 ? 
ATOM   149  O  O   . ARG A 1 24  ? 42.667 -1.132  20.933 1.000 16.396 0 24  ARG A O   1 ? 
ATOM   150  C  CB  . ARG A 1 24  ? 39.622 0.015   20.490 1.000 16.202 0 24  ARG A CB  1 ? 
ATOM   151  C  CG  . ARG A 1 24  ? 39.636 -1.218  19.599 1.000 16.454 0 24  ARG A CG  1 ? 
ATOM   152  C  CD  . ARG A 1 24  ? 39.710 -2.501  20.368 1.000 15.959 0 24  ARG A CD  1 ? 
ATOM   153  N  NE  . ARG A 1 24  ? 39.505 -3.616  19.437 1.000 18.260 0 24  ARG A NE  1 ? 
ATOM   154  C  CZ  . ARG A 1 24  ? 39.841 -4.860  19.670 1.000 18.432 0 24  ARG A CZ  1 ? 
ATOM   155  N  NH1 . ARG A 1 24  ? 40.342 -5.236  20.839 1.000 18.311 0 24  ARG A NH1 1 ? 
ATOM   156  N  NH2 . ARG A 1 24  ? 39.758 -5.704  18.646 1.000 21.668 0 24  ARG A NH2 1 ? 
ATOM   157  N  N   . LYS A 1 25  ? 42.557 0.928   20.110 1.000 15.378 0 25  LYS A N   1 ? 
ATOM   158  C  CA  . LYS A 1 25  ? 43.885 0.834   19.475 1.000 16.345 0 25  LYS A CA  1 ? 
ATOM   159  C  C   . LYS A 1 25  ? 44.982 0.536   20.480 1.000 16.824 0 25  LYS A C   1 ? 
ATOM   160  O  O   . LYS A 1 25  ? 45.886 -0.277  20.206 1.000 18.414 0 25  LYS A O   1 ? 
ATOM   161  C  CB  . LYS A 1 25  ? 44.237 2.116   18.733 1.000 19.687 0 25  LYS A CB  1 ? 
ATOM   162  C  CG  . LYS A 1 25  ? 43.501 2.259   17.428 1.000 30.007 0 25  LYS A CG  1 ? 
ATOM   163  C  CD  . LYS A 1 25  ? 44.205 1.628   16.231 1.000 37.404 0 25  LYS A CD  1 ? 
ATOM   164  C  CE  . LYS A 1 25  ? 43.612 2.067   14.929 1.000 44.098 0 25  LYS A CE  1 ? 
ATOM   165  N  NZ  . LYS A 1 25  ? 42.277 1.490   14.768 1.000 50.901 0 25  LYS A NZ  1 ? 
ATOM   166  N  N   . ALA A 1 26  ? 44.873 1.147   21.666 1.000 16.767 0 26  ALA A N   1 ? 
ATOM   167  C  CA  . ALA A 1 26  ? 45.839 0.945   22.720 1.000 17.260 0 26  ALA A CA  1 ? 
ATOM   168  C  C   . ALA A 1 26  ? 45.848 -0.515  23.189 1.000 18.080 0 26  ALA A C   1 ? 
ATOM   169  O  O   . ALA A 1 26  ? 46.907 -0.975  23.630 1.000 16.792 0 26  ALA A O   1 ? 
ATOM   170  C  CB  . ALA A 1 26  ? 45.596 1.908   23.872 1.000 15.996 0 26  ALA A CB  1 ? 
ATOM   171  N  N   . MET A 1 27  ? 44.695 -1.187  23.211 1.000 15.569 0 27  MET A N   1 ? 
ATOM   172  C  CA  . MET A 1 27  ? 44.599 -2.536  23.756 1.000 13.765 0 27  MET A CA  1 ? 
ATOM   173  C  C   . MET A 1 27  ? 44.653 -3.636  22.702 1.000 16.177 0 27  MET A C   1 ? 
ATOM   174  O  O   . MET A 1 27  ? 45.027 -4.751  23.044 1.000 17.132 0 27  MET A O   1 ? 
ATOM   175  C  CB  . MET A 1 27  ? 43.350 -2.654  24.641 1.000 14.648 0 27  MET A CB  1 ? 
ATOM   176  C  CG  . MET A 1 27  ? 43.376 -1.703  25.774 1.000 14.603 0 27  MET A CG  1 ? 
ATOM   177  S  SD  . MET A 1 27  ? 42.017 -1.869  26.929 1.000 17.784 0 27  MET A SD  1 ? 
ATOM   178  C  CE  . MET A 1 27  ? 40.904 -0.777  26.035 1.000 16.266 0 27  MET A CE  1 ? 
ATOM   179  N  N   . LYS A 1 28  ? 44.172 -3.378  21.488 1.000 17.446 0 28  LYS A N   1 ? 
ATOM   180  C  CA  . LYS A 1 28  ? 44.053 -4.449  20.523 1.000 17.997 0 28  LYS A CA  1 ? 
ATOM   181  C  C   . LYS A 1 28  ? 45.418 -5.080  20.217 1.000 19.722 0 28  LYS A C   1 ? 
ATOM   182  O  O   . LYS A 1 28  ? 46.353 -4.382  19.926 1.000 18.927 0 28  LYS A O   1 ? 
ATOM   183  C  CB  . LYS A 1 28  ? 43.564 -3.871  19.201 1.000 19.685 0 28  LYS A CB  1 ? 
ATOM   184  C  CG  . LYS A 1 28  ? 43.148 -4.972  18.201 1.000 20.947 0 28  LYS A CG  1 ? 
ATOM   185  C  CD  . LYS A 1 28  ? 42.618 -4.360  16.923 1.000 24.948 0 28  LYS A CD  1 ? 
ATOM   186  C  CE  . LYS A 1 28  ? 42.590 -5.370  15.806 1.000 27.444 0 28  LYS A CE  1 ? 
ATOM   187  N  NZ  . LYS A 1 28  ? 41.771 -4.857  14.712 1.000 32.729 0 28  LYS A NZ  1 ? 
ATOM   188  N  N   . GLY A 1 29  ? 45.438 -6.406  20.121 1.000 20.637 0 29  GLY A N   1 ? 
ATOM   189  C  CA  . GLY A 1 29  ? 46.684 -7.079  19.783 1.000 23.468 0 29  GLY A CA  1 ? 
ATOM   190  C  C   . GLY A 1 29  ? 47.535 -7.355  21.009 1.000 20.711 0 29  GLY A C   1 ? 
ATOM   191  O  O   . GLY A 1 29  ? 47.303 -6.850  22.100 1.000 22.115 0 29  GLY A O   1 ? 
ATOM   192  N  N   . LEU A 1 30  ? 48.618 -8.148  20.859 1.000 20.026 0 30  LEU A N   1 ? 
ATOM   193  C  CA  . LEU A 1 30  ? 49.467 -8.444  21.998 1.000 20.330 0 30  LEU A CA  1 ? 
ATOM   194  C  C   . LEU A 1 30  ? 49.962 -7.126  22.566 1.000 19.047 0 30  LEU A C   1 ? 
ATOM   195  O  O   . LEU A 1 30  ? 50.272 -6.197  21.804 1.000 20.176 0 30  LEU A O   1 ? 
ATOM   196  C  CB  . LEU A 1 30  ? 50.662 -9.307  21.546 1.000 25.585 0 30  LEU A CB  1 ? 
ATOM   197  C  CG  . LEU A 1 30  ? 51.703 -9.625  22.645 1.000 30.228 0 30  LEU A CG  1 ? 
ATOM   198  C  CD1 . LEU A 1 30  ? 51.239 -10.270 23.975 1.000 33.112 0 30  LEU A CD1 1 ? 
ATOM   199  C  CD2 . LEU A 1 30  ? 52.801 -10.540 22.048 1.000 33.773 0 30  LEU A CD2 1 ? 
ATOM   200  N  N   . GLY A 1 31  ? 50.050 -7.069  23.891 1.000 20.099 0 31  GLY A N   1 ? 
ATOM   201  C  CA  . GLY A 1 31  ? 50.561 -5.900  24.603 1.000 19.632 0 31  GLY A CA  1 ? 
ATOM   202  C  C   . GLY A 1 31  ? 49.483 -4.810  24.740 1.000 19.869 0 31  GLY A C   1 ? 
ATOM   203  O  O   . GLY A 1 31  ? 48.352 -4.958  24.316 1.000 18.345 0 31  GLY A O   1 ? 
ATOM   204  N  N   . THR A 1 32  ? 49.920 -3.701  25.298 1.000 17.090 0 32  THR A N   1 ? 
ATOM   205  C  CA  . THR A 1 32  ? 49.054 -2.574  25.622 1.000 19.829 0 32  THR A CA  1 ? 
ATOM   206  C  C   . THR A 1 32  ? 49.879 -1.312  25.479 1.000 19.033 0 32  THR A C   1 ? 
ATOM   207  O  O   . THR A 1 32  ? 51.076 -1.312  25.761 1.000 18.709 0 32  THR A O   1 ? 
ATOM   208  C  CB  . THR A 1 32  ? 48.547 -2.715  27.059 1.000 19.489 0 32  THR A CB  1 ? 
ATOM   209  O  OG1 . THR A 1 32  ? 48.046 -4.024  27.306 1.000 20.635 0 32  THR A OG1 1 ? 
ATOM   210  C  CG2 . THR A 1 32  ? 47.509 -1.664  27.366 1.000 21.090 0 32  THR A CG2 1 ? 
ATOM   211  N  N   . ASP A 1 33  ? 49.278 -0.223  24.972 1.000 18.397 0 33  ASP A N   1 ? 
ATOM   212  C  CA  . ASP A 1 33  ? 49.852 1.101   25.097 1.000 17.422 0 33  ASP A CA  1 ? 
ATOM   213  C  C   . ASP A 1 33  ? 49.261 1.789   26.335 1.000 17.770 0 33  ASP A C   1 ? 
ATOM   214  O  O   . ASP A 1 33  ? 48.283 2.524   26.259 1.000 17.785 0 33  ASP A O   1 ? 
ATOM   215  C  CB  . ASP A 1 33  ? 49.630 1.870   23.810 1.000 18.583 0 33  ASP A CB  1 ? 
ATOM   216  C  CG  . ASP A 1 33  ? 50.248 3.247   23.797 1.000 19.539 0 33  ASP A CG  1 ? 
ATOM   217  O  OD1 . ASP A 1 33  ? 50.815 3.634   24.843 1.000 19.210 0 33  ASP A OD1 1 ? 
ATOM   218  O  OD2 . ASP A 1 33  ? 50.131 3.909   22.760 1.000 21.172 0 33  ASP A OD2 1 ? 
ATOM   219  N  N   . GLU A 1 34  ? 49.893 1.579   27.481 1.000 16.236 0 34  GLU A N   1 ? 
ATOM   220  C  CA  . GLU A 1 34  ? 49.363 2.147   28.714 1.000 18.214 0 34  GLU A CA  1 ? 
ATOM   221  C  C   . GLU A 1 34  ? 49.409 3.678   28.723 1.000 17.272 0 34  GLU A C   1 ? 
ATOM   222  O  O   . GLU A 1 34  ? 48.517 4.321   29.277 1.000 18.274 0 34  GLU A O   1 ? 
ATOM   223  C  CB  . GLU A 1 34  ? 50.078 1.629   29.946 1.000 17.616 0 34  GLU A CB  1 ? 
ATOM   224  C  CG  . GLU A 1 34  ? 50.111 0.117   30.130 1.000 19.679 0 34  GLU A CG  1 ? 
ATOM   225  C  CD  . GLU A 1 34  ? 51.270 -0.579  29.392 1.000 22.428 0 34  GLU A CD  1 ? 
ATOM   226  O  OE1 . GLU A 1 34  ? 51.990 0.037   28.608 1.000 25.174 0 34  GLU A OE1 1 ? 
ATOM   227  O  OE2 . GLU A 1 34  ? 51.315 -1.806  29.635 1.000 29.903 0 34  GLU A OE2 1 ? 
ATOM   228  N  N   . ASP A 1 35  ? 50.457 4.263   28.127 1.000 17.970 0 35  ASP A N   1 ? 
ATOM   229  C  CA  . ASP A 1 35  ? 50.530 5.710   28.050 1.000 19.324 0 35  ASP A CA  1 ? 
ATOM   230  C  C   . ASP A 1 35  ? 49.294 6.254   27.334 1.000 17.285 0 35  ASP A C   1 ? 
ATOM   231  O  O   . ASP A 1 35  ? 48.756 7.274   27.763 1.000 19.304 0 35  ASP A O   1 ? 
ATOM   232  C  CB  . ASP A 1 35  ? 51.742 6.227   27.272 1.000 21.487 0 35  ASP A CB  1 ? 
ATOM   233  C  CG  . ASP A 1 35  ? 53.091 5.942   27.907 1.000 30.915 0 35  ASP A CG  1 ? 
ATOM   234  O  OD1 . ASP A 1 35  ? 53.192 5.995   29.153 1.000 31.171 0 35  ASP A OD1 1 ? 
ATOM   235  O  OD2 . ASP A 1 35  ? 54.056 5.730   27.118 1.000 32.977 0 35  ASP A OD2 1 ? 
ATOM   236  N  N   . ALA A 1 36  ? 48.848 5.613   26.240 1.000 18.673 0 36  ALA A N   1 ? 
ATOM   237  C  CA  . ALA A 1 36  ? 47.704 6.112   25.494 1.000 18.072 0 36  ALA A CA  1 ? 
ATOM   238  C  C   . ALA A 1 36  ? 46.466 6.085   26.403 1.000 16.952 0 36  ALA A C   1 ? 
ATOM   239  O  O   . ALA A 1 36  ? 45.621 6.962   26.367 1.000 20.031 0 36  ALA A O   1 ? 
ATOM   240  C  CB  . ALA A 1 36  ? 47.487 5.310   24.218 1.000 17.661 0 36  ALA A CB  1 ? 
ATOM   241  N  N   . ILE A 1 37  ? 46.353 5.003   27.170 1.000 14.296 0 37  ILE A N   1 ? 
ATOM   242  C  CA  . ILE A 1 37  ? 45.222 4.882   28.087 1.000 13.617 0 37  ILE A CA  1 ? 
ATOM   243  C  C   . ILE A 1 37  ? 45.192 6.074   29.041 1.000 15.877 0 37  ILE A C   1 ? 
ATOM   244  O  O   . ILE A 1 37  ? 44.101 6.640   29.309 1.000 16.366 0 37  ILE A O   1 ? 
ATOM   245  C  CB  . ILE A 1 37  ? 45.208 3.515   28.793 1.000 14.393 0 37  ILE A CB  1 ? 
ATOM   246  C  CG1 . ILE A 1 37  ? 44.959 2.404   27.784 1.000 15.441 0 37  ILE A CG1 1 ? 
ATOM   247  C  CG2 . ILE A 1 37  ? 44.137 3.500   29.906 1.000 14.306 0 37  ILE A CG2 1 ? 
ATOM   248  C  CD1 . ILE A 1 37  ? 45.150 1.007   28.273 1.000 16.653 0 37  ILE A CD1 1 ? 
ATOM   249  N  N   . ILE A 1 38  ? 46.325 6.333   29.699 1.000 16.232 0 38  ILE A N   1 ? 
ATOM   250  C  CA  . ILE A 1 38  ? 46.461 7.480   30.591 1.000 15.643 0 38  ILE A CA  1 ? 
ATOM   251  C  C   . ILE A 1 38  ? 46.089 8.765   29.869 1.000 17.639 0 38  ILE A C   1 ? 
ATOM   252  O  O   . ILE A 1 38  ? 45.338 9.597   30.397 1.000 17.159 0 38  ILE A O   1 ? 
ATOM   253  C  CB  . ILE A 1 38  ? 47.861 7.550   31.204 1.000 17.385 0 38  ILE A CB  1 ? 
ATOM   254  C  CG1 . ILE A 1 38  ? 48.174 6.300   31.992 1.000 17.658 0 38  ILE A CG1 1 ? 
ATOM   255  C  CG2 . ILE A 1 38  ? 48.029 8.837   32.025 1.000 19.519 0 38  ILE A CG2 1 ? 
ATOM   256  C  CD1 . ILE A 1 38  ? 49.606 6.215   32.484 1.000 18.506 0 38  ILE A CD1 1 ? 
ATOM   257  N  N   . SER A 1 39  ? 46.658 8.949   28.675 1.000 15.584 0 39  SER A N   1 ? 
ATOM   258  C  CA  . SER A 1 39  ? 46.504 10.209  27.960 1.000 17.921 0 39  SER A CA  1 ? 
ATOM   259  C  C   . SER A 1 39  ? 45.037 10.538  27.647 1.000 19.087 0 39  SER A C   1 ? 
ATOM   260  O  O   . SER A 1 39  ? 44.673 11.727  27.534 1.000 18.848 0 39  SER A O   1 ? 
ATOM   261  C  CB  . SER A 1 39  ? 47.318 10.218  26.690 1.000 21.726 0 39  SER A CB  1 ? 
ATOM   262  O  OG  . SER A 1 39  ? 46.665 9.385   25.727 1.000 30.669 0 39  SER A OG  1 ? 
ATOM   263  N  N   . VAL A 1 40  ? 44.162 9.529   27.555 1.000 16.714 0 40  VAL A N   1 ? 
ATOM   264  C  CA  . VAL A 1 40  ? 42.734 9.740   27.434 1.000 16.062 0 40  VAL A CA  1 ? 
ATOM   265  C  C   . VAL A 1 40  ? 42.130 9.901   28.825 1.000 16.870 0 40  VAL A C   1 ? 
ATOM   266  O  O   . VAL A 1 40  ? 41.569 10.942  29.146 1.000 16.725 0 40  VAL A O   1 ? 
ATOM   267  C  CB  . VAL A 1 40  ? 41.984 8.641   26.671 1.000 15.897 0 40  VAL A CB  1 ? 
ATOM   268  C  CG1 . VAL A 1 40  ? 40.454 8.824   26.644 1.000 17.388 0 40  VAL A CG1 1 ? 
ATOM   269  C  CG2 . VAL A 1 40  ? 42.524 8.527   25.235 1.000 17.542 0 40  VAL A CG2 1 ? 
ATOM   270  N  N   . LEU A 1 41  ? 42.206 8.820   29.628 1.000 16.425 0 41  LEU A N   1 ? 
ATOM   271  C  CA  . LEU A 1 41  ? 41.335 8.717   30.802 1.000 15.375 0 41  LEU A CA  1 ? 
ATOM   272  C  C   . LEU A 1 41  ? 41.690 9.730   31.903 1.000 14.855 0 41  LEU A C   1 ? 
ATOM   273  O  O   . LEU A 1 41  ? 40.772 10.180  32.601 1.000 14.178 0 41  LEU A O   1 ? 
ATOM   274  C  CB  . LEU A 1 41  ? 41.375 7.288   31.317 1.000 16.405 0 41  LEU A CB  1 ? 
ATOM   275  C  CG  . LEU A 1 41  ? 40.761 6.274   30.350 1.000 16.930 0 41  LEU A CG  1 ? 
ATOM   276  C  CD1 . LEU A 1 41  ? 40.884 4.878   30.953 1.000 15.985 0 41  LEU A CD1 1 ? 
ATOM   277  C  CD2 . LEU A 1 41  ? 39.329 6.554   29.958 1.000 18.211 0 41  LEU A CD2 1 ? 
ATOM   278  N  N   . ALA A 1 42  ? 42.973 10.031  32.078 1.000 17.534 0 42  ALA A N   1 ? 
ATOM   279  C  CA  . ALA A 1 42  ? 43.341 10.970  33.119 1.000 14.544 0 42  ALA A CA  1 ? 
ATOM   280  C  C   . ALA A 1 42  ? 43.053 12.417  32.743 1.000 16.248 0 42  ALA A C   1 ? 
ATOM   281  O  O   . ALA A 1 42  ? 43.287 13.295  33.558 1.000 16.449 0 42  ALA A O   1 ? 
ATOM   282  C  CB  . ALA A 1 42  ? 44.788 10.766  33.508 1.000 15.982 0 42  ALA A CB  1 ? 
ATOM   283  N  N   . TYR A 1 43  ? 42.621 12.657  31.510 1.000 14.996 0 43  TYR A N   1 ? 
ATOM   284  C  CA  . TYR A 1 43  ? 42.354 13.987  30.991 1.000 17.143 0 43  TYR A CA  1 ? 
ATOM   285  C  C   . TYR A 1 43  ? 40.874 14.128  30.630 1.000 17.115 0 43  TYR A C   1 ? 
ATOM   286  O  O   . TYR A 1 43  ? 40.479 15.015  29.852 1.000 16.353 0 43  TYR A O   1 ? 
ATOM   287  C  CB  . TYR A 1 43  ? 43.244 14.322  29.810 1.000 17.693 0 43  TYR A CB  1 ? 
ATOM   288  C  CG  . TYR A 1 43  ? 44.710 14.435  30.204 1.000 19.806 0 43  TYR A CG  1 ? 
ATOM   289  C  CD1 . TYR A 1 43  ? 45.222 15.634  30.702 1.000 24.169 0 43  TYR A CD1 1 ? 
ATOM   290  C  CD2 . TYR A 1 43  ? 45.520 13.309  30.212 1.000 20.270 0 43  TYR A CD2 1 ? 
ATOM   291  C  CE1 . TYR A 1 43  ? 46.555 15.702  31.116 1.000 24.465 0 43  TYR A CE1 1 ? 
ATOM   292  C  CE2 . TYR A 1 43  ? 46.858 13.389  30.593 1.000 25.861 0 43  TYR A CE2 1 ? 
ATOM   293  C  CZ  . TYR A 1 43  ? 47.369 14.593  31.022 1.000 25.069 0 43  TYR A CZ  1 ? 
ATOM   294  O  OH  . TYR A 1 43  ? 48.679 14.630  31.463 1.000 34.288 0 43  TYR A OH  1 ? 
ATOM   295  N  N   . ARG A 1 44  ? 40.025 13.259  31.178 1.000 15.654 0 44  ARG A N   1 ? 
ATOM   296  C  CA  . ARG A 1 44  ? 38.577 13.373  31.092 1.000 16.576 0 44  ARG A CA  1 ? 
ATOM   297  C  C   . ARG A 1 44  ? 38.084 13.309  32.517 1.000 16.923 0 44  ARG A C   1 ? 
ATOM   298  O  O   . ARG A 1 44  ? 38.660 12.589  33.347 1.000 16.844 0 44  ARG A O   1 ? 
ATOM   299  C  CB  . ARG A 1 44  ? 37.969 12.216  30.265 1.000 16.170 0 44  ARG A CB  1 ? 
ATOM   300  C  CG  . ARG A 1 44  ? 38.589 12.017  28.880 1.000 16.052 0 44  ARG A CG  1 ? 
ATOM   301  C  CD  . ARG A 1 44  ? 38.207 13.170  27.963 1.000 14.486 0 44  ARG A CD  1 ? 
ATOM   302  N  NE  . ARG A 1 44  ? 38.890 12.911  26.713 1.000 16.288 0 44  ARG A NE  1 ? 
ATOM   303  C  CZ  . ARG A 1 44  ? 40.105 13.159  26.347 1.000 18.093 0 44  ARG A CZ  1 ? 
ATOM   304  N  NH1 . ARG A 1 44  ? 40.852 13.965  27.075 1.000 17.891 0 44  ARG A NH1 1 ? 
ATOM   305  N  NH2 . ARG A 1 44  ? 40.582 12.626  25.250 1.000 18.064 0 44  ARG A NH2 1 ? 
ATOM   306  N  N   . ASN A 1 45  ? 36.955 13.916  32.831 1.000 15.719 0 45  ASN A N   1 ? 
ATOM   307  C  CA  . ASN A 1 45  ? 36.406 13.777  34.169 1.000 14.773 0 45  ASN A CA  1 ? 
ATOM   308  C  C   . ASN A 1 45  ? 35.528 12.519  34.292 1.000 15.195 0 45  ASN A C   1 ? 
ATOM   309  O  O   . ASN A 1 45  ? 35.361 11.805  33.321 1.000 14.441 0 45  ASN A O   1 ? 
ATOM   310  C  CB  . ASN A 1 45  ? 35.698 15.047  34.640 1.000 16.666 0 45  ASN A CB  1 ? 
ATOM   311  C  CG  . ASN A 1 45  ? 34.402 15.331  33.928 1.000 17.384 0 45  ASN A CG  1 ? 
ATOM   312  O  OD1 . ASN A 1 45  ? 33.860 14.491  33.209 1.000 19.095 0 45  ASN A OD1 1 ? 
ATOM   313  N  ND2 . ASN A 1 45  ? 33.810 16.469  34.265 1.000 21.632 0 45  ASN A ND2 1 ? 
ATOM   314  N  N   . THR A 1 46  ? 35.088 12.152  35.511 1.000 14.116 0 46  THR A N   1 ? 
ATOM   315  C  CA  . THR A 1 46  ? 34.423 10.871  35.711 1.000 15.772 0 46  THR A CA  1 ? 
ATOM   316  C  C   . THR A 1 46  ? 33.171 10.763  34.846 1.000 14.400 0 46  THR A C   1 ? 
ATOM   317  O  O   . THR A 1 46  ? 32.863 9.695   34.305 1.000 15.792 0 46  THR A O   1 ? 
ATOM   318  C  CB  . THR A 1 46  ? 34.075 10.689  37.183 1.000 18.892 0 46  THR A CB  1 ? 
ATOM   319  O  OG1 . THR A 1 46  ? 35.251 10.862  37.969 1.000 19.157 0 46  THR A OG1 1 ? 
ATOM   320  C  CG2 . THR A 1 46  ? 33.503 9.315   37.486 1.000 18.479 0 46  THR A CG2 1 ? 
ATOM   321  N  N   . ALA A 1 47  ? 32.399 11.880  34.735 1.000 15.082 0 47  ALA A N   1 ? 
ATOM   322  C  CA  . ALA A 1 47  ? 31.188 11.894  33.922 1.000 15.542 0 47  ALA A CA  1 ? 
ATOM   323  C  C   . ALA A 1 47  ? 31.572 11.617  32.472 1.000 16.166 0 47  ALA A C   1 ? 
ATOM   324  O  O   . ALA A 1 47  ? 30.877 10.849  31.803 1.000 14.895 0 47  ALA A O   1 ? 
ATOM   325  C  CB  . ALA A 1 47  ? 30.496 13.254  34.050 1.000 18.703 0 47  ALA A CB  1 ? 
ATOM   326  N  N   . GLN A 1 48  ? 32.653 12.227  31.992 1.000 13.590 0 48  GLN A N   1 ? 
ATOM   327  C  CA  . GLN A 1 48  ? 33.065 12.023  30.599 1.000 14.621 0 48  GLN A CA  1 ? 
ATOM   328  C  C   . GLN A 1 48  ? 33.495 10.579  30.362 1.000 14.165 0 48  GLN A C   1 ? 
ATOM   329  O  O   . GLN A 1 48  ? 33.194 9.954   29.356 1.000 15.559 0 48  GLN A O   1 ? 
ATOM   330  C  CB  . GLN A 1 48  ? 34.168 13.001  30.243 1.000 15.298 0 48  GLN A CB  1 ? 
ATOM   331  C  CG  . GLN A 1 48  ? 33.619 14.417  30.111 1.000 16.501 0 48  GLN A CG  1 ? 
ATOM   332  C  CD  . GLN A 1 48  ? 34.682 15.411  29.728 1.000 15.434 0 48  GLN A CD  1 ? 
ATOM   333  O  OE1 . GLN A 1 48  ? 35.819 15.350  30.182 1.000 16.757 0 48  GLN A OE1 1 ? 
ATOM   334  N  NE2 . GLN A 1 48  ? 34.296 16.442  28.975 1.000 16.633 0 48  GLN A NE2 1 ? 
ATOM   335  N  N   . ARG A 1 49  ? 34.107 9.985   31.366 1.000 12.256 0 49  ARG A N   1 ? 
ATOM   336  C  CA  . ARG A 1 49  ? 34.525 8.602   31.240 1.000 12.267 0 49  ARG A CA  1 ? 
ATOM   337  C  C   . ARG A 1 49  ? 33.285 7.697   31.117 1.000 13.508 0 49  ARG A C   1 ? 
ATOM   338  O  O   . ARG A 1 49  ? 33.354 6.668   30.457 1.000 12.775 0 49  ARG A O   1 ? 
ATOM   339  C  CB  . ARG A 1 49  ? 35.324 8.246   32.475 1.000 12.573 0 49  ARG A CB  1 ? 
ATOM   340  C  CG  . ARG A 1 49  ? 36.710 8.850   32.515 1.000 13.794 0 49  ARG A CG  1 ? 
ATOM   341  C  CD  . ARG A 1 49  ? 37.465 8.424   33.771 1.000 16.151 0 49  ARG A CD  1 ? 
ATOM   342  N  NE  . ARG A 1 49  ? 38.589 9.284   34.143 1.000 16.690 0 49  ARG A NE  1 ? 
ATOM   343  C  CZ  . ARG A 1 49  ? 38.721 9.894   35.327 1.000 16.021 0 49  ARG A CZ  1 ? 
ATOM   344  N  NH1 . ARG A 1 49  ? 37.845 9.631   36.303 1.000 16.262 0 49  ARG A NH1 1 ? 
ATOM   345  N  NH2 . ARG A 1 49  ? 39.576 10.897  35.416 1.000 18.164 0 49  ARG A NH2 1 ? 
ATOM   346  N  N   . GLN A 1 50  ? 32.153 8.048   31.718 1.000 13.458 0 50  GLN A N   1 ? 
ATOM   347  C  CA  . GLN A 1 50  ? 30.940 7.258   31.519 1.000 14.691 0 50  GLN A CA  1 ? 
ATOM   348  C  C   . GLN A 1 50  ? 30.469 7.352   30.077 1.000 14.427 0 50  GLN A C   1 ? 
ATOM   349  O  O   . GLN A 1 50  ? 29.995 6.361   29.505 1.000 17.235 0 50  GLN A O   1 ? 
ATOM   350  C  CB  . GLN A 1 50  ? 29.867 7.611   32.550 1.000 15.128 0 50  GLN A CB  1 ? 
ATOM   351  C  CG  . GLN A 1 50  ? 30.400 7.667   33.973 1.000 14.908 0 50  GLN A CG  1 ? 
ATOM   352  C  CD  . GLN A 1 50  ? 31.226 6.464   34.364 1.000 15.782 0 50  GLN A CD  1 ? 
ATOM   353  O  OE1 . GLN A 1 50  ? 32.341 6.631   34.912 1.000 19.444 0 50  GLN A OE1 1 ? 
ATOM   354  N  NE2 . GLN A 1 50  ? 30.683 5.281   34.187 1.000 14.410 0 50  GLN A NE2 1 ? 
ATOM   355  N  N   . GLU A 1 51  ? 30.587 8.526   29.463 1.000 15.415 0 51  GLU A N   1 ? 
ATOM   356  C  CA  . GLU A 1 51  ? 30.212 8.667   28.059 1.000 16.920 0 51  GLU A CA  1 ? 
ATOM   357  C  C   . GLU A 1 51  ? 31.134 7.842   27.163 1.000 15.727 0 51  GLU A C   1 ? 
ATOM   358  O  O   . GLU A 1 51  ? 30.691 7.312   26.148 1.000 15.740 0 51  GLU A O   1 ? 
ATOM   359  C  CB  . GLU A 1 51  ? 30.252 10.124  27.634 1.000 16.997 0 51  GLU A CB  1 ? 
ATOM   360  C  CG  . GLU A 1 51  ? 29.238 10.990  28.378 1.000 22.155 0 51  GLU A CG  1 ? 
ATOM   361  C  CD  . GLU A 1 51  ? 27.812 10.921  27.921 1.000 33.450 0 51  GLU A CD  1 ? 
ATOM   362  O  OE1 . GLU A 1 51  ? 27.492 10.285  26.887 1.000 33.682 0 51  GLU A OE1 1 ? 
ATOM   363  O  OE2 . GLU A 1 51  ? 27.054 11.590  28.657 1.000 43.118 0 51  GLU A OE2 1 ? 
ATOM   364  N  N   . ILE A 1 52  ? 32.419 7.763   27.490 1.000 15.550 0 52  ILE A N   1 ? 
ATOM   365  C  CA  . ILE A 1 52  ? 33.337 6.892   26.768 1.000 14.999 0 52  ILE A CA  1 ? 
ATOM   366  C  C   . ILE A 1 52  ? 32.866 5.449   26.861 1.000 14.239 0 52  ILE A C   1 ? 
ATOM   367  O  O   . ILE A 1 52  ? 32.900 4.736   25.866 1.000 14.590 0 52  ILE A O   1 ? 
ATOM   368  C  CB  . ILE A 1 52  ? 34.805 7.077   27.217 1.000 14.540 0 52  ILE A CB  1 ? 
ATOM   369  C  CG1 . ILE A 1 52  ? 35.237 8.529   26.949 1.000 14.996 0 52  ILE A CG1 1 ? 
ATOM   370  C  CG2 . ILE A 1 52  ? 35.690 6.085   26.460 1.000 13.508 0 52  ILE A CG2 1 ? 
ATOM   371  C  CD1 . ILE A 1 52  ? 36.555 8.927   27.584 1.000 15.860 0 52  ILE A CD1 1 ? 
ATOM   372  N  N   . ARG A 1 53  ? 32.509 4.971   28.069 1.000 13.593 0 53  ARG A N   1 ? 
ATOM   373  C  CA  . ARG A 1 53  ? 32.047 3.596   28.207 1.000 14.625 0 53  ARG A CA  1 ? 
ATOM   374  C  C   . ARG A 1 53  ? 30.904 3.306   27.242 1.000 15.098 0 53  ARG A C   1 ? 
ATOM   375  O  O   . ARG A 1 53  ? 30.869 2.256   26.588 1.000 15.662 0 53  ARG A O   1 ? 
ATOM   376  C  CB  . ARG A 1 53  ? 31.594 3.261   29.626 1.000 16.467 0 53  ARG A CB  1 ? 
ATOM   377  C  CG  . ARG A 1 53  ? 32.684 3.237   30.677 1.000 18.472 0 53  ARG A CG  1 ? 
ATOM   378  C  CD  . ARG A 1 53  ? 32.095 3.123   32.080 1.000 18.916 0 53  ARG A CD  1 ? 
ATOM   379  N  NE  . ARG A 1 53  ? 31.540 1.793   32.311 1.000 19.756 0 53  ARG A NE  1 ? 
ATOM   380  C  CZ  . ARG A 1 53  ? 30.999 1.452   33.475 1.000 25.535 0 53  ARG A CZ  1 ? 
ATOM   381  N  NH1 . ARG A 1 53  ? 30.902 2.366   34.424 1.000 25.000 0 53  ARG A NH1 1 ? 
ATOM   382  N  NH2 . ARG A 1 53  ? 30.546 0.228   33.700 1.000 24.780 0 53  ARG A NH2 1 ? 
ATOM   383  N  N   . THR A 1 54  ? 29.928 4.218   27.187 1.000 14.790 0 54  THR A N   1 ? 
ATOM   384  C  CA  . THR A 1 54  ? 28.760 4.061   26.324 1.000 15.978 0 54  THR A CA  1 ? 
ATOM   385  C  C   . THR A 1 54  ? 29.197 4.027   24.869 1.000 15.667 0 54  THR A C   1 ? 
ATOM   386  O  O   . THR A 1 54  ? 28.800 3.125   24.079 1.000 15.720 0 54  THR A O   1 ? 
ATOM   387  C  CB  . THR A 1 54  ? 27.804 5.204   26.606 1.000 17.487 0 54  THR A CB  1 ? 
ATOM   388  O  OG1 . THR A 1 54  ? 27.405 5.066   27.960 1.000 19.238 0 54  THR A OG1 1 ? 
ATOM   389  C  CG2 . THR A 1 54  ? 26.613 5.069   25.681 1.000 19.932 0 54  THR A CG2 1 ? 
ATOM   390  N  N   . ALA A 1 55  ? 30.010 5.005   24.458 1.000 15.102 0 55  ALA A N   1 ? 
ATOM   391  C  CA  . ALA A 1 55  ? 30.538 5.103   23.100 1.000 15.312 0 55  ALA A CA  1 ? 
ATOM   392  C  C   . ALA A 1 55  ? 31.381 3.875   22.737 1.000 16.826 0 55  ALA A C   1 ? 
ATOM   393  O  O   . ALA A 1 55  ? 31.430 3.454   21.601 1.000 18.933 0 55  ALA A O   1 ? 
ATOM   394  C  CB  . ALA A 1 55  ? 31.352 6.355   22.894 1.000 15.903 0 55  ALA A CB  1 ? 
ATOM   395  N  N   . TYR A 1 56  ? 32.066 3.259   23.696 1.000 13.323 0 56  TYR A N   1 ? 
ATOM   396  C  CA  . TYR A 1 56  ? 32.921 2.139   23.369 1.000 15.480 0 56  TYR A CA  1 ? 
ATOM   397  C  C   . TYR A 1 56  ? 32.029 0.973   22.925 1.000 15.410 0 56  TYR A C   1 ? 
ATOM   398  O  O   . TYR A 1 56  ? 32.386 0.223   21.995 1.000 15.723 0 56  TYR A O   1 ? 
ATOM   399  C  CB  . TYR A 1 56  ? 33.756 1.846   24.604 1.000 16.164 0 56  TYR A CB  1 ? 
ATOM   400  C  CG  . TYR A 1 56  ? 34.945 0.905   24.369 1.000 16.115 0 56  TYR A CG  1 ? 
ATOM   401  C  CD1 . TYR A 1 56  ? 36.168 1.377   23.947 1.000 15.429 0 56  TYR A CD1 1 ? 
ATOM   402  C  CD2 . TYR A 1 56  ? 34.855 -0.468  24.619 1.000 16.678 0 56  TYR A CD2 1 ? 
ATOM   403  C  CE1 . TYR A 1 56  ? 37.261 0.555   23.765 1.000 15.595 0 56  TYR A CE1 1 ? 
ATOM   404  C  CE2 . TYR A 1 56  ? 35.958 -1.298  24.499 1.000 16.654 0 56  TYR A CE2 1 ? 
ATOM   405  C  CZ  . TYR A 1 56  ? 37.174 -0.798  24.060 1.000 18.933 0 56  TYR A CZ  1 ? 
ATOM   406  O  OH  . TYR A 1 56  ? 38.258 -1.660  23.947 1.000 18.480 0 56  TYR A OH  1 ? 
ATOM   407  N  N   . LYS A 1 57  ? 30.905 0.795   23.635 1.000 14.690 0 57  LYS A N   1 ? 
ATOM   408  C  CA  . LYS A 1 57  ? 29.999 -0.298  23.245 1.000 14.299 0 57  LYS A CA  1 ? 
ATOM   409  C  C   . LYS A 1 57  ? 29.507 -0.070  21.806 1.000 16.255 0 57  LYS A C   1 ? 
ATOM   410  O  O   . LYS A 1 57  ? 29.465 -1.002  21.002 1.000 16.856 0 57  LYS A O   1 ? 
ATOM   411  C  CB  . LYS A 1 57  ? 28.840 -0.426  24.225 1.000 15.475 0 57  LYS A CB  1 ? 
ATOM   412  C  CG  . LYS A 1 57  ? 29.258 -0.933  25.609 1.000 17.917 0 57  LYS A CG  1 ? 
ATOM   413  C  CD  . LYS A 1 57  ? 28.055 -1.010  26.567 1.000 22.797 0 57  LYS A CD  1 ? 
ATOM   414  C  CE  . LYS A 1 57  ? 28.331 -1.930  27.692 1.000 32.287 0 57  LYS A CE  1 ? 
ATOM   415  N  NZ  . LYS A 1 57  ? 27.201 -1.947  28.629 1.000 37.643 0 57  LYS A NZ  1 ? 
ATOM   416  N  N   . SER A 1 58  ? 29.153 1.179   21.452 1.000 18.257 0 58  SER A N   1 ? 
ATOM   417  C  CA  . SER A 1 58  ? 28.472 1.433   20.197 1.000 19.687 0 58  SER A CA  1 ? 
ATOM   418  C  C   . SER A 1 58  ? 29.430 1.648   19.036 1.000 22.498 0 58  SER A C   1 ? 
ATOM   419  O  O   . SER A 1 58  ? 28.993 1.612   17.882 1.000 21.843 0 58  SER A O   1 ? 
ATOM   420  C  CB  . SER A 1 58  ? 27.566 2.647   20.312 1.000 21.364 0 58  SER A CB  1 ? 
ATOM   421  O  OG  . SER A 1 58  ? 28.351 3.798   20.554 1.000 25.049 0 58  SER A OG  1 ? 
ATOM   422  N  N   . THR A 1 59  ? 30.686 2.000   19.310 1.000 16.843 0 59  THR A N   1 ? 
ATOM   423  C  CA  . THR A 1 59  ? 31.698 2.308   18.309 1.000 16.151 0 59  THR A CA  1 ? 
ATOM   424  C  C   . THR A 1 59  ? 32.623 1.111   18.093 1.000 18.328 0 59  THR A C   1 ? 
ATOM   425  O  O   . THR A 1 59  ? 33.220 0.956   17.023 1.000 19.222 0 59  THR A O   1 ? 
ATOM   426  C  CB  . THR A 1 59  ? 32.496 3.538   18.740 1.000 21.286 0 59  THR A CB  1 ? 
ATOM   427  O  OG1 . THR A 1 59  ? 31.578 4.559   19.059 1.000 24.596 0 59  THR A OG1 1 ? 
ATOM   428  C  CG2 . THR A 1 59  ? 33.485 4.043   17.711 1.000 25.381 0 59  THR A CG2 1 ? 
ATOM   429  N  N   . ILE A 1 60  ? 32.917 0.397   19.177 1.000 16.766 0 60  ILE A N   1 ? 
ATOM   430  C  CA  . ILE A 1 60  ? 33.905 -0.681  19.140 1.000 17.107 0 60  ILE A CA  1 ? 
ATOM   431  C  C   . ILE A 1 60  ? 33.241 -2.055  19.205 1.000 18.209 0 60  ILE A C   1 ? 
ATOM   432  O  O   . ILE A 1 60  ? 33.826 -3.047  18.791 1.000 19.863 0 60  ILE A O   1 ? 
ATOM   433  C  CB  . ILE A 1 60  ? 34.928 -0.520  20.277 1.000 16.464 0 60  ILE A CB  1 ? 
ATOM   434  C  CG1 . ILE A 1 60  ? 35.494 0.898   20.286 1.000 15.716 0 60  ILE A CG1 1 ? 
ATOM   435  C  CG2 . ILE A 1 60  ? 36.067 -1.559  20.233 1.000 17.488 0 60  ILE A CG2 1 ? 
ATOM   436  C  CD1 . ILE A 1 60  ? 36.242 1.312   19.035 1.000 16.068 0 60  ILE A CD1 1 ? 
ATOM   437  N  N   . GLY A 1 61  ? 32.061 -2.145  19.815 1.000 18.939 0 61  GLY A N   1 ? 
ATOM   438  C  CA  . GLY A 1 61  ? 31.344 -3.407  19.917 1.000 18.311 0 61  GLY A CA  1 ? 
ATOM   439  C  C   . GLY A 1 61  ? 31.920 -4.273  21.015 1.000 18.914 0 61  GLY A C   1 ? 
ATOM   440  O  O   . GLY A 1 61  ? 31.794 -5.495  20.986 1.000 19.867 0 61  GLY A O   1 ? 
ATOM   441  N  N   . ARG A 1 62  ? 32.446 -3.625  22.041 1.000 18.254 0 62  ARG A N   1 ? 
ATOM   442  C  CA  . ARG A 1 62  ? 33.100 -4.283  23.157 1.000 18.698 0 62  ARG A CA  1 ? 
ATOM   443  C  C   . ARG A 1 62  ? 32.770 -3.548  24.444 1.000 17.609 0 62  ARG A C   1 ? 
ATOM   444  O  O   . ARG A 1 62  ? 32.238 -2.442  24.423 1.000 18.313 0 62  ARG A O   1 ? 
ATOM   445  C  CB  . ARG A 1 62  ? 34.607 -4.343  22.870 1.000 18.027 0 62  ARG A CB  1 ? 
ATOM   446  C  CG  . ARG A 1 62  ? 35.014 -5.124  21.640 1.000 18.103 0 62  ARG A CG  1 ? 
ATOM   447  C  CD  . ARG A 1 62  ? 36.540 -5.117  21.462 1.000 18.308 0 62  ARG A CD  1 ? 
ATOM   448  N  NE  . ARG A 1 62  ? 37.280 -5.755  22.550 1.000 18.876 0 62  ARG A NE  1 ? 
ATOM   449  C  CZ  . ARG A 1 62  ? 37.841 -6.970  22.471 1.000 21.195 0 62  ARG A CZ  1 ? 
ATOM   450  N  NH1 . ARG A 1 62  ? 37.718 -7.679  21.375 1.000 23.173 0 62  ARG A NH1 1 ? 
ATOM   451  N  NH2 . ARG A 1 62  ? 38.439 -7.500  23.497 1.000 21.709 0 62  ARG A NH2 1 ? 
ATOM   452  N  N   . ASP A 1 63  ? 33.233 -4.098  25.570 1.000 18.007 0 63  ASP A N   1 ? 
ATOM   453  C  CA  . ASP A 1 63  ? 33.023 -3.504  26.876 1.000 18.388 0 63  ASP A CA  1 ? 
ATOM   454  C  C   . ASP A 1 63  ? 34.332 -2.966  27.420 1.000 17.407 0 63  ASP A C   1 ? 
ATOM   455  O  O   . ASP A 1 63  ? 35.342 -3.668  27.514 1.000 17.455 0 63  ASP A O   1 ? 
ATOM   456  C  CB  . ASP A 1 63  ? 32.408 -4.524  27.830 1.000 21.296 0 63  ASP A CB  1 ? 
ATOM   457  C  CG  . ASP A 1 63  ? 31.083 -5.002  27.265 1.000 30.558 0 63  ASP A CG  1 ? 
ATOM   458  O  OD1 . ASP A 1 63  ? 30.314 -4.109  26.829 1.000 33.643 0 63  ASP A OD1 1 ? 
ATOM   459  O  OD2 . ASP A 1 63  ? 30.862 -6.246  27.188 1.000 40.113 0 63  ASP A OD2 1 ? 
ATOM   460  N  N   . LEU A 1 64  ? 34.317 -1.664  27.729 1.000 16.630 0 64  LEU A N   1 ? 
ATOM   461  C  CA  . LEU A 1 64  ? 35.548 -0.987  28.083 1.000 15.571 0 64  LEU A CA  1 ? 
ATOM   462  C  C   . LEU A 1 64  ? 36.145 -1.479  29.388 1.000 16.376 0 64  LEU A C   1 ? 
ATOM   463  O  O   . LEU A 1 64  ? 37.365 -1.644  29.497 1.000 16.607 0 64  LEU A O   1 ? 
ATOM   464  C  CB  . LEU A 1 64  ? 35.315 0.531   28.130 1.000 15.110 0 64  LEU A CB  1 ? 
ATOM   465  C  CG  . LEU A 1 64  ? 36.553 1.387   28.472 1.000 14.488 0 64  LEU A CG  1 ? 
ATOM   466  C  CD1 . LEU A 1 64  ? 37.752 1.148   27.619 1.000 14.504 0 64  LEU A CD1 1 ? 
ATOM   467  C  CD2 . LEU A 1 64  ? 36.219 2.839   28.367 1.000 14.583 0 64  LEU A CD2 1 ? 
ATOM   468  N  N   . ILE A 1 65  ? 35.302 -1.593  30.421 1.000 18.386 0 65  ILE A N   1 ? 
ATOM   469  C  CA  . ILE A 1 65  ? 35.838 -1.992  31.715 1.000 20.608 0 65  ILE A CA  1 ? 
ATOM   470  C  C   . ILE A 1 65  ? 36.398 -3.413  31.590 1.000 19.245 0 65  ILE A C   1 ? 
ATOM   471  O  O   . ILE A 1 65  ? 37.461 -3.718  32.150 1.000 19.195 0 65  ILE A O   1 ? 
ATOM   472  C  CB  . ILE A 1 65  ? 34.721 -1.987  32.775 1.000 23.879 0 65  ILE A CB  1 ? 
ATOM   473  C  CG1 . ILE A 1 65  ? 34.074 -0.640  32.879 1.000 31.415 0 65  ILE A CG1 1 ? 
ATOM   474  C  CG2 . ILE A 1 65  ? 35.253 -2.473  34.133 1.000 26.461 0 65  ILE A CG2 1 ? 
ATOM   475  C  CD1 . ILE A 1 65  ? 35.052 0.409   33.300 1.000 29.162 0 65  ILE A CD1 1 ? 
ATOM   476  N  N   . ASP A 1 66  ? 35.678 -4.280  30.877 1.000 23.129 0 66  ASP A N   1 ? 
ATOM   477  C  CA  . ASP A 1 66  ? 36.112 -5.661  30.719 1.000 22.956 0 66  ASP A CA  1 ? 
ATOM   478  C  C   . ASP A 1 66  ? 37.487 -5.707  30.036 1.000 20.090 0 66  ASP A C   1 ? 
ATOM   479  O  O   . ASP A 1 66  ? 38.417 -6.419  30.435 1.000 21.261 0 66  ASP A O   1 ? 
ATOM   480  C  CB  . ASP A 1 66  ? 35.135 -6.484  29.906 1.000 25.095 0 66  ASP A CB  1 ? 
ATOM   481  C  CG  . ASP A 1 66  ? 33.864 -6.910  30.629 1.000 30.005 0 66  ASP A CG  1 ? 
ATOM   482  O  OD1 . ASP A 1 66  ? 33.836 -6.766  31.865 1.000 35.656 0 66  ASP A OD1 1 ? 
ATOM   483  O  OD2 . ASP A 1 66  ? 32.890 -7.275  29.928 1.000 37.085 0 66  ASP A OD2 1 ? 
ATOM   484  N  N   . ASP A 1 67  ? 37.638 -4.882  29.014 1.000 16.862 0 67  ASP A N   1 ? 
ATOM   485  C  CA  . ASP A 1 67  ? 38.880 -4.838  28.286 1.000 16.601 0 67  ASP A CA  1 ? 
ATOM   486  C  C   . ASP A 1 67  ? 39.989 -4.335  29.207 1.000 17.299 0 67  ASP A C   1 ? 
ATOM   487  O  O   . ASP A 1 67  ? 41.094 -4.833  29.148 1.000 16.849 0 67  ASP A O   1 ? 
ATOM   488  C  CB  . ASP A 1 67  ? 38.772 -4.075  26.976 1.000 17.864 0 67  ASP A CB  1 ? 
ATOM   489  C  CG  . ASP A 1 67  ? 38.062 -4.766  25.847 1.000 19.045 0 67  ASP A CG  1 ? 
ATOM   490  O  OD1 . ASP A 1 67  ? 37.673 -5.965  26.052 1.000 21.490 0 67  ASP A OD1 1 ? 
ATOM   491  O  OD2 . ASP A 1 67  ? 37.911 -4.112  24.786 1.000 19.391 0 67  ASP A OD2 1 ? 
ATOM   492  N  N   . LEU A 1 68  ? 39.757 -3.211  29.901 1.000 15.909 0 68  LEU A N   1 ? 
ATOM   493  C  CA  . LEU A 1 68  ? 40.753 -2.679  30.802 1.000 16.476 0 68  LEU A CA  1 ? 
ATOM   494  C  C   . LEU A 1 68  ? 41.175 -3.721  31.829 1.000 19.623 0 68  LEU A C   1 ? 
ATOM   495  O  O   . LEU A 1 68  ? 42.370 -3.859  32.107 1.000 18.466 0 68  LEU A O   1 ? 
ATOM   496  C  CB  . LEU A 1 68  ? 40.249 -1.395  31.446 1.000 15.322 0 68  LEU A CB  1 ? 
ATOM   497  C  CG  . LEU A 1 68  ? 40.122 -0.198  30.501 1.000 15.266 0 68  LEU A CG  1 ? 
ATOM   498  C  CD1 . LEU A 1 68  ? 39.252 0.846   31.193 1.000 14.351 0 68  LEU A CD1 1 ? 
ATOM   499  C  CD2 . LEU A 1 68  ? 41.463 0.330   30.071 1.000 15.750 0 68  LEU A CD2 1 ? 
ATOM   500  N  N   . LYS A 1 69  ? 40.187 -4.431  32.379 1.000 17.770 0 69  LYS A N   1 ? 
ATOM   501  C  CA  . LYS A 1 69  ? 40.508 -5.428  33.389 1.000 18.231 0 69  LYS A CA  1 ? 
ATOM   502  C  C   . LYS A 1 69  ? 41.355 -6.544  32.802 1.000 21.054 0 69  LYS A C   1 ? 
ATOM   503  O  O   . LYS A 1 69  ? 42.211 -7.066  33.487 1.000 20.801 0 69  LYS A O   1 ? 
ATOM   504  C  CB  . LYS A 1 69  ? 39.290 -5.986  34.111 1.000 17.969 0 69  LYS A CB  1 ? 
ATOM   505  C  CG  . LYS A 1 69  ? 38.635 -5.022  35.057 1.000 20.422 0 69  LYS A CG  1 ? 
ATOM   506  C  CD  . LYS A 1 69  ? 37.393 -5.526  35.772 1.000 22.367 0 69  LYS A CD  1 ? 
ATOM   507  C  CE  . LYS A 1 69  ? 36.860 -4.470  36.663 1.000 28.314 0 69  LYS A CE  1 ? 
ATOM   508  N  NZ  . LYS A 1 69  ? 35.595 -4.902  37.257 1.000 33.649 0 69  LYS A NZ  1 ? 
ATOM   509  N  N   . SER A 1 70  ? 41.050 -6.970  31.602 1.000 19.922 0 70  SER A N   1 ? 
ATOM   510  C  CA  . SER A 1 70  ? 41.799 -8.002  30.908 1.000 21.348 0 70  SER A CA  1 ? 
ATOM   511  C  C   . SER A 1 70  ? 43.231 -7.566  30.603 1.000 22.025 0 70  SER A C   1 ? 
ATOM   512  O  O   . SER A 1 70  ? 44.190 -8.355  30.701 1.000 25.848 0 70  SER A O   1 ? 
ATOM   513  C  CB  . SER A 1 70  ? 41.047 -8.357  29.655 1.000 23.544 0 70  SER A CB  1 ? 
ATOM   514  O  OG  . SER A 1 70  ? 41.732 -9.428  29.026 1.000 34.881 0 70  SER A OG  1 ? 
ATOM   515  N  N   . GLU A 1 71  ? 43.420 -6.303  30.210 1.000 16.936 0 71  GLU A N   1 ? 
ATOM   516  C  CA  . GLU A 1 71  ? 44.704 -5.889  29.698 1.000 19.214 0 71  GLU A CA  1 ? 
ATOM   517  C  C   . GLU A 1 71  ? 45.658 -5.481  30.819 1.000 17.958 0 71  GLU A C   1 ? 
ATOM   518  O  O   . GLU A 1 71  ? 46.852 -5.557  30.688 1.000 20.989 0 71  GLU A O   1 ? 
ATOM   519  C  CB  . GLU A 1 71  ? 44.448 -4.660  28.821 1.000 16.839 0 71  GLU A CB  1 ? 
ATOM   520  C  CG  . GLU A 1 71  ? 43.805 -4.988  27.490 1.000 19.643 0 71  GLU A CG  1 ? 
ATOM   521  C  CD  . GLU A 1 71  ? 44.746 -5.470  26.400 1.000 18.456 0 71  GLU A CD  1 ? 
ATOM   522  O  OE1 . GLU A 1 71  ? 45.814 -4.897  26.240 1.000 20.490 0 71  GLU A OE1 1 ? 
ATOM   523  O  OE2 . GLU A 1 71  ? 44.332 -6.394  25.629 1.000 20.536 0 71  GLU A OE2 1 ? 
ATOM   524  N  N   . LEU A 1 72  ? 45.129 -4.925  31.889 1.000 17.392 0 72  LEU A N   1 ? 
ATOM   525  C  CA  . LEU A 1 72  ? 45.945 -4.228  32.881 1.000 19.633 0 72  LEU A CA  1 ? 
ATOM   526  C  C   . LEU A 1 72  ? 46.060 -5.112  34.107 1.000 20.635 0 72  LEU A C   1 ? 
ATOM   527  O  O   . LEU A 1 72  ? 45.259 -6.031  34.252 1.000 23.195 0 72  LEU A O   1 ? 
ATOM   528  C  CB  . LEU A 1 72  ? 45.267 -2.914  33.260 1.000 16.800 0 72  LEU A CB  1 ? 
ATOM   529  C  CG  . LEU A 1 72  ? 45.055 -1.917  32.117 1.000 18.003 0 72  LEU A CG  1 ? 
ATOM   530  C  CD1 . LEU A 1 72  ? 44.576 -0.587  32.716 1.000 18.999 0 72  LEU A CD1 1 ? 
ATOM   531  C  CD2 . LEU A 1 72  ? 46.347 -1.711  31.334 1.000 17.919 0 72  LEU A CD2 1 ? 
ATOM   532  N  N   . SER A 1 73  ? 46.999 -4.821  35.006 1.000 18.224 0 73  SER A N   1 ? 
ATOM   533  C  CA  . SER A 1 73  ? 47.076 -5.564  36.233 1.000 20.319 0 73  SER A CA  1 ? 
ATOM   534  C  C   . SER A 1 73  ? 47.481 -4.676  37.374 1.000 19.431 0 73  SER A C   1 ? 
ATOM   535  O  O   . SER A 1 73  ? 47.884 -3.534  37.179 1.000 19.662 0 73  SER A O   1 ? 
ATOM   536  C  CB  . SER A 1 73  ? 48.036 -6.745  36.099 1.000 23.903 0 73  SER A CB  1 ? 
ATOM   537  O  OG  . SER A 1 73  ? 49.277 -6.272  35.655 1.000 30.274 0 73  SER A OG  1 ? 
ATOM   538  N  N   . GLY A 1 74  ? 47.458 -5.272  38.571 1.000 20.641 0 74  GLY A N   1 ? 
ATOM   539  C  CA  . GLY A 1 74  ? 48.032 -4.623  39.743 1.000 20.468 0 74  GLY A CA  1 ? 
ATOM   540  C  C   . GLY A 1 74  ? 47.445 -3.242  40.085 1.000 19.482 0 74  GLY A C   1 ? 
ATOM   541  O  O   . GLY A 1 74  ? 46.267 -2.968  39.899 1.000 19.161 0 74  GLY A O   1 ? 
ATOM   542  N  N   . ASN A 1 75  ? 48.318 -2.415  40.660 1.000 19.879 0 75  ASN A N   1 ? 
ATOM   543  C  CA  . ASN A 1 75  ? 47.946 -1.103  41.132 1.000 17.935 0 75  ASN A CA  1 ? 
ATOM   544  C  C   . ASN A 1 75  ? 47.522 -0.193  39.990 1.000 18.648 0 75  ASN A C   1 ? 
ATOM   545  O  O   . ASN A 1 75  ? 46.582 0.560   40.165 1.000 16.003 0 75  ASN A O   1 ? 
ATOM   546  C  CB  . ASN A 1 75  ? 49.037 -0.469  41.975 1.000 19.354 0 75  ASN A CB  1 ? 
ATOM   547  C  CG  . ASN A 1 75  ? 49.285 -1.171  43.280 1.000 22.844 0 75  ASN A CG  1 ? 
ATOM   548  O  OD1 . ASN A 1 75  ? 50.444 -1.419  43.652 1.000 29.187 0 75  ASN A OD1 1 ? 
ATOM   549  N  ND2 . ASN A 1 75  ? 48.231 -1.463  43.972 1.000 24.314 0 75  ASN A ND2 1 ? 
ATOM   550  N  N   . PHE A 1 76  ? 48.168 -0.311  38.819 1.000 17.462 0 76  PHE A N   1 ? 
ATOM   551  C  CA  . PHE A 1 76  ? 47.694 0.451   37.679 1.000 16.223 0 76  PHE A CA  1 ? 
ATOM   552  C  C   . PHE A 1 76  ? 46.264 0.094   37.283 1.000 17.307 0 76  PHE A C   1 ? 
ATOM   553  O  O   . PHE A 1 76  ? 45.446 1.008   37.067 1.000 15.790 0 76  PHE A O   1 ? 
ATOM   554  C  CB  . PHE A 1 76  ? 48.665 0.309   36.510 1.000 14.863 0 76  PHE A CB  1 ? 
ATOM   555  C  CG  . PHE A 1 76  ? 48.291 1.124   35.291 1.000 16.015 0 76  PHE A CG  1 ? 
ATOM   556  C  CD1 . PHE A 1 76  ? 48.330 2.507   35.320 1.000 15.849 0 76  PHE A CD1 1 ? 
ATOM   557  C  CD2 . PHE A 1 76  ? 48.044 0.511   34.081 1.000 16.591 0 76  PHE A CD2 1 ? 
ATOM   558  C  CE1 . PHE A 1 76  ? 47.989 3.254   34.216 1.000 17.401 0 76  PHE A CE1 1 ? 
ATOM   559  C  CE2 . PHE A 1 76  ? 47.737 1.266   32.967 1.000 16.626 0 76  PHE A CE2 1 ? 
ATOM   560  C  CZ  . PHE A 1 76  ? 47.722 2.629   33.035 1.000 14.940 0 76  PHE A CZ  1 ? 
ATOM   561  N  N   . GLU A 1 77  ? 45.906 -1.202  37.241 1.000 16.698 0 77  GLU A N   1 ? 
ATOM   562  C  CA  . GLU A 1 77  ? 44.554 -1.610  36.949 1.000 17.287 0 77  GLU A CA  1 ? 
ATOM   563  C  C   . GLU A 1 77  ? 43.628 -1.012  38.007 1.000 15.988 0 77  GLU A C   1 ? 
ATOM   564  O  O   . GLU A 1 77  ? 42.554 -0.525  37.709 1.000 16.357 0 77  GLU A O   1 ? 
ATOM   565  C  CB  . GLU A 1 77  ? 44.412 -3.126  36.906 1.000 17.611 0 77  GLU A CB  1 ? 
ATOM   566  C  CG  . GLU A 1 77  ? 42.981 -3.595  36.650 1.000 19.585 0 77  GLU A CG  1 ? 
ATOM   567  C  CD  . GLU A 1 77  ? 42.773 -5.097  36.666 1.000 26.081 0 77  GLU A CD  1 ? 
ATOM   568  O  OE1 . GLU A 1 77  ? 43.795 -5.776  36.737 1.000 33.342 0 77  GLU A OE1 1 ? 
ATOM   569  O  OE2 . GLU A 1 77  ? 41.605 -5.537  36.663 1.000 27.305 0 77  GLU A OE2 1 ? 
ATOM   570  N  N   . GLN A 1 78  ? 44.082 -1.024  39.270 1.000 16.191 0 78  GLN A N   1 ? 
ATOM   571  C  CA  . GLN A 1 78  ? 43.189 -0.560  40.330 1.000 14.713 0 78  GLN A CA  1 ? 
ATOM   572  C  C   . GLN A 1 78  ? 42.833 0.922   40.161 1.000 15.962 0 78  GLN A C   1 ? 
ATOM   573  O  O   . GLN A 1 78  ? 41.657 1.326   40.392 1.000 14.604 0 78  GLN A O   1 ? 
ATOM   574  C  CB  . GLN A 1 78  ? 43.793 -0.860  41.691 1.000 14.886 0 78  GLN A CB  1 ? 
ATOM   575  C  CG  . GLN A 1 78  ? 42.863 -0.576  42.866 1.000 16.053 0 78  GLN A CG  1 ? 
ATOM   576  C  CD  . GLN A 1 78  ? 43.504 -0.919  44.190 1.000 19.707 0 78  GLN A CD  1 ? 
ATOM   577  O  OE1 . GLN A 1 78  ? 44.331 -1.822  44.242 1.000 21.471 0 78  GLN A OE1 1 ? 
ATOM   578  N  NE2 . GLN A 1 78  ? 43.055 -0.256  45.240 1.000 20.060 0 78  GLN A NE2 1 ? 
ATOM   579  N  N   . VAL A 1 79  ? 43.849 1.715   39.850 1.000 15.620 0 79  VAL A N   1 ? 
ATOM   580  C  CA  . VAL A 1 79  ? 43.639 3.144   39.646 1.000 14.459 0 79  VAL A CA  1 ? 
ATOM   581  C  C   . VAL A 1 79  ? 42.749 3.377   38.437 1.000 14.891 0 79  VAL A C   1 ? 
ATOM   582  O  O   . VAL A 1 79  ? 41.798 4.158   38.550 1.000 13.479 0 79  VAL A O   1 ? 
ATOM   583  C  CB  . VAL A 1 79  ? 44.933 3.951   39.438 1.000 16.262 0 79  VAL A CB  1 ? 
ATOM   584  C  CG1 . VAL A 1 79  ? 44.610 5.433   39.207 1.000 17.399 0 79  VAL A CG1 1 ? 
ATOM   585  C  CG2 . VAL A 1 79  ? 45.871 3.838   40.625 1.000 18.166 0 79  VAL A CG2 1 ? 
ATOM   586  N  N   . ILE A 1 80  ? 43.068 2.705   37.320 1.000 13.070 0 80  ILE A N   1 ? 
ATOM   587  C  CA  . ILE A 1 80  ? 42.279 2.967   36.109 1.000 13.638 0 80  ILE A CA  1 ? 
ATOM   588  C  C   . ILE A 1 80  ? 40.806 2.559   36.264 1.000 16.146 0 80  ILE A C   1 ? 
ATOM   589  O  O   . ILE A 1 80  ? 39.872 3.252   35.860 1.000 14.859 0 80  ILE A O   1 ? 
ATOM   590  C  CB  . ILE A 1 80  ? 42.908 2.276   34.895 1.000 14.253 0 80  ILE A CB  1 ? 
ATOM   591  C  CG1 . ILE A 1 80  ? 44.221 2.848   34.504 1.000 14.881 0 80  ILE A CG1 1 ? 
ATOM   592  C  CG2 . ILE A 1 80  ? 41.939 2.279   33.692 1.000 15.045 0 80  ILE A CG2 1 ? 
ATOM   593  C  CD1 . ILE A 1 80  ? 44.218 4.306   34.119 1.000 16.762 0 80  ILE A CD1 1 ? 
ATOM   594  N  N   . VAL A 1 81  ? 40.579 1.355   36.794 1.000 14.773 0 81  VAL A N   1 ? 
ATOM   595  C  CA  . VAL A 1 81  ? 39.214 0.904   37.025 1.000 16.512 0 81  VAL A CA  1 ? 
ATOM   596  C  C   . VAL A 1 81  ? 38.487 1.819   38.016 1.000 15.504 0 81  VAL A C   1 ? 
ATOM   597  O  O   . VAL A 1 81  ? 37.312 2.120   37.825 1.000 16.711 0 81  VAL A O   1 ? 
ATOM   598  C  CB  . VAL A 1 81  ? 39.207 -0.566  37.482 1.000 20.833 0 81  VAL A CB  1 ? 
ATOM   599  C  CG1 . VAL A 1 81  ? 37.829 -0.984  37.994 1.000 21.136 0 81  VAL A CG1 1 ? 
ATOM   600  C  CG2 . VAL A 1 81  ? 39.716 -1.486  36.398 1.000 22.122 0 81  VAL A CG2 1 ? 
ATOM   601  N  N   . GLY A 1 82  ? 39.220 2.301   39.054 1.000 14.226 0 82  GLY A N   1 ? 
ATOM   602  C  CA  . GLY A 1 82  ? 38.704 3.294   39.975 1.000 14.930 0 82  GLY A CA  1 ? 
ATOM   603  C  C   . GLY A 1 82  ? 38.202 4.534   39.251 1.000 14.956 0 82  GLY A C   1 ? 
ATOM   604  O  O   . GLY A 1 82  ? 37.114 5.041   39.498 1.000 15.391 0 82  GLY A O   1 ? 
ATOM   605  N  N   . MET A 1 83  ? 39.076 5.063   38.400 1.000 13.644 0 83  MET A N   1 ? 
ATOM   606  C  CA  . MET A 1 83  ? 38.751 6.241   37.603 1.000 13.117 0 83  MET A CA  1 ? 
ATOM   607  C  C   . MET A 1 83  ? 37.506 6.045   36.741 1.000 14.837 0 83  MET A C   1 ? 
ATOM   608  O  O   . MET A 1 83  ? 36.743 6.981   36.497 1.000 14.123 0 83  MET A O   1 ? 
ATOM   609  C  CB  . MET A 1 83  ? 39.951 6.647   36.752 1.000 10.791 0 83  MET A CB  1 ? 
ATOM   610  C  CG  . MET A 1 83  ? 41.103 7.219   37.577 1.000 11.397 0 83  MET A CG  1 ? 
ATOM   611  S  SD  . MET A 1 83  ? 42.631 7.279   36.655 1.000 15.820 0 83  MET A SD  1 ? 
ATOM   612  C  CE  . MET A 1 83  ? 42.118 8.207   35.203 1.000 16.275 0 83  MET A CE  1 ? 
ATOM   613  N  N   . MET A 1 84  ? 37.312 4.820   36.284 1.000 13.740 0 84  MET A N   1 ? 
ATOM   614  C  CA  . MET A 1 84  ? 36.225 4.487   35.392 1.000 14.269 0 84  MET A CA  1 ? 
ATOM   615  C  C   . MET A 1 84  ? 34.884 4.328   36.123 1.000 15.597 0 84  MET A C   1 ? 
ATOM   616  O  O   . MET A 1 84  ? 33.818 4.249   35.475 1.000 17.239 0 84  MET A O   1 ? 
ATOM   617  C  CB  . MET A 1 84  ? 36.462 3.185   34.604 1.000 13.874 0 84  MET A CB  1 ? 
ATOM   618  C  CG  . MET A 1 84  ? 37.581 3.266   33.535 1.000 13.574 0 84  MET A CG  1 ? 
ATOM   619  S  SD  . MET A 1 84  ? 37.356 4.624   32.371 1.000 16.716 0 84  MET A SD  1 ? 
ATOM   620  C  CE  . MET A 1 84  ? 35.707 4.302   31.732 1.000 19.834 0 84  MET A CE  1 ? 
ATOM   621  N  N   . THR A 1 85  ? 34.928 4.223   37.449 1.000 14.828 0 85  THR A N   1 ? 
ATOM   622  C  CA  . THR A 1 85  ? 33.766 3.962   38.271 1.000 14.676 0 85  THR A CA  1 ? 
ATOM   623  C  C   . THR A 1 85  ? 33.041 5.254   38.616 1.000 15.846 0 85  THR A C   1 ? 
ATOM   624  O  O   . THR A 1 85  ? 33.661 6.221   39.068 1.000 15.750 0 85  THR A O   1 ? 
ATOM   625  C  CB  . THR A 1 85  ? 34.206 3.226   39.529 1.000 14.691 0 85  THR A CB  1 ? 
ATOM   626  O  OG1 . THR A 1 85  ? 34.864 2.044   39.109 1.000 16.670 0 85  THR A OG1 1 ? 
ATOM   627  C  CG2 . THR A 1 85  ? 33.049 2.777   40.397 1.000 16.617 0 85  THR A CG2 1 ? 
ATOM   628  N  N   . PRO A 1 86  ? 31.694 5.317   38.417 1.000 14.333 0 86  PRO A N   1 ? 
ATOM   629  C  CA  . PRO A 1 86  ? 30.899 6.454   38.883 1.000 15.512 0 86  PRO A CA  1 ? 
ATOM   630  C  C   . PRO A 1 86  ? 31.247 6.800   40.328 1.000 14.278 0 86  PRO A C   1 ? 
ATOM   631  O  O   . PRO A 1 86  ? 31.488 5.895   41.125 1.000 13.911 0 86  PRO A O   1 ? 
ATOM   632  C  CB  . PRO A 1 86  ? 29.395 5.996   38.682 1.000 19.512 0 86  PRO A CB  1 ? 
ATOM   633  C  CG  . PRO A 1 86  ? 29.483 4.943   37.623 1.000 19.655 0 86  PRO A CG  1 ? 
ATOM   634  C  CD  . PRO A 1 86  ? 30.876 4.315   37.700 1.000 17.267 0 86  PRO A CD  1 ? 
ATOM   635  N  N   . THR A 1 87  ? 31.211 8.082   40.677 1.000 15.812 0 87  THR A N   1 ? 
ATOM   636  C  CA  . THR A 1 87  ? 31.698 8.590   41.958 1.000 17.192 0 87  THR A CA  1 ? 
ATOM   637  C  C   . THR A 1 87  ? 31.044 7.859   43.139 1.000 16.381 0 87  THR A C   1 ? 
ATOM   638  O  O   . THR A 1 87  ? 31.727 7.420   44.088 1.000 14.256 0 87  THR A O   1 ? 
ATOM   639  C  CB  . THR A 1 87  ? 31.397 10.095  41.976 1.000 20.935 0 87  THR A CB  1 ? 
ATOM   640  O  OG1 . THR A 1 87  ? 32.082 10.616  40.843 1.000 24.071 0 87  THR A OG1 1 ? 
ATOM   641  C  CG2 . THR A 1 87  ? 31.963 10.769  43.203 1.000 22.696 0 87  THR A CG2 1 ? 
ATOM   642  N  N   . VAL A 1 88  ? 29.713 7.807   43.132 1.000 16.864 0 88  VAL A N   1 ? 
ATOM   643  C  CA  . VAL A 1 88  ? 28.982 7.259   44.277 1.000 15.195 0 88  VAL A CA  1 ? 
ATOM   644  C  C   . VAL A 1 88  ? 29.286 5.778   44.389 1.000 14.234 0 88  VAL A C   1 ? 
ATOM   645  O  O   . VAL A 1 88  ? 29.634 5.234   45.456 1.000 16.405 0 88  VAL A O   1 ? 
ATOM   646  C  CB  . VAL A 1 88  ? 27.476 7.545   44.206 1.000 16.746 0 88  VAL A CB  1 ? 
ATOM   647  C  CG1 . VAL A 1 88  ? 26.752 6.867   45.357 1.000 18.324 0 88  VAL A CG1 1 ? 
ATOM   648  C  CG2 . VAL A 1 88  ? 27.265 9.060   44.189 1.000 17.934 0 88  VAL A CG2 1 ? 
ATOM   649  N  N   . LEU A 1 89  ? 29.252 5.096   43.241 1.000 14.168 0 89  LEU A N   1 ? 
ATOM   650  C  CA  . LEU A 1 89  ? 29.518 3.676   43.235 1.000 16.338 0 89  LEU A CA  1 ? 
ATOM   651  C  C   . LEU A 1 89  ? 30.938 3.341   43.708 1.000 15.578 0 89  LEU A C   1 ? 
ATOM   652  O  O   . LEU A 1 89  ? 31.192 2.317   44.324 1.000 14.602 0 89  LEU A O   1 ? 
ATOM   653  C  CB  . LEU A 1 89  ? 29.134 3.104   41.860 1.000 17.139 0 89  LEU A CB  1 ? 
ATOM   654  C  CG  . LEU A 1 89  ? 29.286 1.593   41.712 1.000 20.916 0 89  LEU A CG  1 ? 
ATOM   655  C  CD1 . LEU A 1 89  ? 28.305 0.928   42.657 1.000 20.759 0 89  LEU A CD1 1 ? 
ATOM   656  C  CD2 . LEU A 1 89  ? 29.059 1.137   40.282 1.000 23.978 0 89  LEU A CD2 1 ? 
ATOM   657  N  N   . TYR A 1 90  ? 31.916 4.192   43.407 1.000 13.715 0 90  TYR A N   1 ? 
ATOM   658  C  CA  . TYR A 1 90  ? 33.277 3.955   43.846 1.000 15.036 0 90  TYR A CA  1 ? 
ATOM   659  C  C   . TYR A 1 90  ? 33.315 3.967   45.367 1.000 16.383 0 90  TYR A C   1 ? 
ATOM   660  O  O   . TYR A 1 90  ? 33.894 3.059   45.978 1.000 15.420 0 90  TYR A O   1 ? 
ATOM   661  C  CB  . TYR A 1 90  ? 34.162 5.032   43.217 1.000 16.889 0 90  TYR A CB  1 ? 
ATOM   662  C  CG  . TYR A 1 90  ? 35.624 4.798   43.578 1.000 15.952 0 90  TYR A CG  1 ? 
ATOM   663  C  CD1 . TYR A 1 90  ? 36.283 3.632   43.186 1.000 16.527 0 90  TYR A CD1 1 ? 
ATOM   664  C  CD2 . TYR A 1 90  ? 36.373 5.720   44.309 1.000 19.285 0 90  TYR A CD2 1 ? 
ATOM   665  C  CE1 . TYR A 1 90  ? 37.629 3.398   43.514 1.000 17.720 0 90  TYR A CE1 1 ? 
ATOM   666  C  CE2 . TYR A 1 90  ? 37.719 5.505   44.606 1.000 19.478 0 90  TYR A CE2 1 ? 
ATOM   667  C  CZ  . TYR A 1 90  ? 38.361 4.340   44.222 1.000 18.501 0 90  TYR A CZ  1 ? 
ATOM   668  O  OH  . TYR A 1 90  ? 39.693 4.128   44.571 1.000 19.891 0 90  TYR A OH  1 ? 
ATOM   669  N  N   . ASP A 1 91  ? 32.580 4.893   45.986 1.000 16.433 0 91  ASP A N   1 ? 
ATOM   670  C  CA  . ASP A 1 91  ? 32.562 4.977   47.449 1.000 14.871 0 91  ASP A CA  1 ? 
ATOM   671  C  C   . ASP A 1 91  ? 31.903 3.720   48.007 1.000 15.084 0 91  ASP A C   1 ? 
ATOM   672  O  O   . ASP A 1 91  ? 32.378 3.140   49.004 1.000 15.906 0 91  ASP A O   1 ? 
ATOM   673  C  CB  . ASP A 1 91  ? 31.898 6.255   47.906 1.000 15.730 0 91  ASP A CB  1 ? 
ATOM   674  C  CG  . ASP A 1 91  ? 32.735 7.520   47.766 1.000 17.846 0 91  ASP A CG  1 ? 
ATOM   675  O  OD1 . ASP A 1 91  ? 33.935 7.427   47.372 1.000 18.748 0 91  ASP A OD1 1 ? 
ATOM   676  O  OD2 . ASP A 1 91  ? 32.161 8.595   48.028 1.000 21.506 0 91  ASP A OD2 1 ? 
ATOM   677  N  N   . VAL A 1 92  ? 30.800 3.337   47.375 1.000 14.627 0 92  VAL A N   1 ? 
ATOM   678  C  CA  . VAL A 1 92  ? 30.049 2.156   47.771 1.000 14.171 0 92  VAL A CA  1 ? 
ATOM   679  C  C   . VAL A 1 92  ? 30.917 0.920   47.723 1.000 16.289 0 92  VAL A C   1 ? 
ATOM   680  O  O   . VAL A 1 92  ? 30.929 0.115   48.656 1.000 14.929 0 92  VAL A O   1 ? 
ATOM   681  C  CB  . VAL A 1 92  ? 28.807 2.019   46.878 1.000 15.813 0 92  VAL A CB  1 ? 
ATOM   682  C  CG1 . VAL A 1 92  ? 28.223 0.629   46.986 1.000 16.235 0 92  VAL A CG1 1 ? 
ATOM   683  C  CG2 . VAL A 1 92  ? 27.794 3.071   47.249 1.000 15.729 0 92  VAL A CG2 1 ? 
ATOM   684  N  N   . GLN A 1 93  ? 31.643 0.772   46.605 1.000 14.949 0 93  GLN A N   1 ? 
ATOM   685  C  CA  . GLN A 1 93  ? 32.463 -0.404  46.434 1.000 15.233 0 93  GLN A CA  1 ? 
ATOM   686  C  C   . GLN A 1 93  ? 33.634 -0.378  47.420 1.000 13.463 0 93  GLN A C   1 ? 
ATOM   687  O  O   . GLN A 1 93  ? 34.053 -1.437  47.906 1.000 15.994 0 93  GLN A O   1 ? 
ATOM   688  C  CB  . GLN A 1 93  ? 32.940 -0.453  44.986 1.000 17.085 0 93  GLN A CB  1 ? 
ATOM   689  C  CG  . GLN A 1 93  ? 31.815 -0.879  44.079 1.000 17.835 0 93  GLN A CG  1 ? 
ATOM   690  C  CD  . GLN A 1 93  ? 32.184 -1.008  42.629 1.000 25.906 0 93  GLN A CD  1 ? 
ATOM   691  O  OE1 . GLN A 1 93  ? 33.239 -0.543  42.202 1.000 22.896 0 93  GLN A OE1 1 ? 
ATOM   692  N  NE2 . GLN A 1 93  ? 31.254 -1.587  41.875 1.000 28.421 0 93  GLN A NE2 1 ? 
ATOM   693  N  N   . GLU A 1 94  ? 34.176 0.809   47.758 1.000 14.816 0 94  GLU A N   1 ? 
ATOM   694  C  CA  . GLU A 1 94  ? 35.270 0.880   48.698 1.000 15.416 0 94  GLU A CA  1 ? 
ATOM   695  C  C   . GLU A 1 94  ? 34.793 0.481   50.082 1.000 14.997 0 94  GLU A C   1 ? 
ATOM   696  O  O   . GLU A 1 94  ? 35.550 -0.177  50.800 1.000 14.668 0 94  GLU A O   1 ? 
ATOM   697  C  CB  . GLU A 1 94  ? 35.945 2.269   48.696 1.000 13.665 0 94  GLU A CB  1 ? 
ATOM   698  C  CG  . GLU A 1 94  ? 36.809 2.481   47.469 1.000 15.779 0 94  GLU A CG  1 ? 
ATOM   699  C  CD  . GLU A 1 94  ? 38.070 1.654   47.523 1.000 22.243 0 94  GLU A CD  1 ? 
ATOM   700  O  OE1 . GLU A 1 94  ? 38.828 1.902   48.473 1.000 20.791 0 94  GLU A OE1 1 ? 
ATOM   701  O  OE2 . GLU A 1 94  ? 38.230 0.693   46.730 1.000 26.577 0 94  GLU A OE2 1 ? 
ATOM   702  N  N   . LEU A 1 95  ? 33.592 0.926   50.468 1.000 15.533 0 95  LEU A N   1 ? 
ATOM   703  C  CA  . LEU A 1 95  ? 33.055 0.550   51.759 1.000 14.968 0 95  LEU A CA  1 ? 
ATOM   704  C  C   . LEU A 1 95  ? 32.858 -0.963  51.796 1.000 15.726 0 95  LEU A C   1 ? 
ATOM   705  O  O   . LEU A 1 95  ? 33.176 -1.613  52.809 1.000 18.050 0 95  LEU A O   1 ? 
ATOM   706  C  CB  . LEU A 1 95  ? 31.777 1.296   52.079 1.000 14.784 0 95  LEU A CB  1 ? 
ATOM   707  C  CG  . LEU A 1 95  ? 31.946 2.786   52.348 1.000 15.495 0 95  LEU A CG  1 ? 
ATOM   708  C  CD1 . LEU A 1 95  ? 30.634 3.503   52.294 1.000 17.015 0 95  LEU A CD1 1 ? 
ATOM   709  C  CD2 . LEU A 1 95  ? 32.623 3.092   53.662 1.000 15.649 0 95  LEU A CD2 1 ? 
ATOM   710  N  N   . ARG A 1 96  ? 32.243 -1.516  50.757 1.000 14.931 0 96  ARG A N   1 ? 
ATOM   711  C  CA  . ARG A 1 96  ? 32.042 -2.966  50.718 1.000 16.221 0 96  ARG A CA  1 ? 
ATOM   712  C  C   . ARG A 1 96  ? 33.368 -3.717  50.888 1.000 17.749 0 96  ARG A C   1 ? 
ATOM   713  O  O   . ARG A 1 96  ? 33.491 -4.681  51.653 1.000 18.699 0 96  ARG A O   1 ? 
ATOM   714  C  CB  . ARG A 1 96  ? 31.302 -3.354  49.424 1.000 17.683 0 96  ARG A CB  1 ? 
ATOM   715  C  CG  . ARG A 1 96  ? 30.941 -4.847  49.402 1.000 20.699 0 96  ARG A CG  1 ? 
ATOM   716  C  CD  . ARG A 1 96  ? 29.646 -5.078  50.146 1.000 26.520 0 96  ARG A CD  1 ? 
ATOM   717  N  NE  . ARG A 1 96  ? 29.470 -6.471  50.569 1.000 35.877 0 96  ARG A NE  1 ? 
ATOM   718  C  CZ  . ARG A 1 96  ? 29.708 -6.929  51.818 1.000 41.203 0 96  ARG A CZ  1 ? 
ATOM   719  N  NH1 . ARG A 1 96  ? 29.818 -6.115  52.879 1.000 34.027 0 96  ARG A NH1 1 ? 
ATOM   720  N  NH2 . ARG A 1 96  ? 29.774 -8.236  51.991 1.000 43.000 0 96  ARG A NH2 1 ? 
ATOM   721  N  N   . ARG A 1 97  ? 34.384 -3.339  50.130 1.000 18.858 0 97  ARG A N   1 ? 
ATOM   722  C  CA  . ARG A 1 97  ? 35.683 -3.984  50.167 1.000 20.447 0 97  ARG A CA  1 ? 
ATOM   723  C  C   . ARG A 1 97  ? 36.269 -3.937  51.572 1.000 19.909 0 97  ARG A C   1 ? 
ATOM   724  O  O   . ARG A 1 97  ? 36.979 -4.850  52.008 1.000 22.301 0 97  ARG A O   1 ? 
ATOM   725  C  CB  . ARG A 1 97  ? 36.563 -3.240  49.160 1.000 23.860 0 97  ARG A CB  1 ? 
ATOM   726  C  CG  . ARG A 1 97  ? 37.861 -3.941  48.841 1.000 33.366 0 97  ARG A CG  1 ? 
ATOM   727  C  CD  . ARG A 1 97  ? 38.293 -3.369  47.495 1.000 34.534 0 97  ARG A CD  1 ? 
ATOM   728  N  NE  . ARG A 1 97  ? 39.727 -3.634  47.411 1.000 44.049 0 97  ARG A NE  1 ? 
ATOM   729  C  CZ  . ARG A 1 97  ? 40.702 -2.741  47.406 1.000 42.931 0 97  ARG A CZ  1 ? 
ATOM   730  N  NH1 . ARG A 1 97  ? 40.463 -1.439  47.564 1.000 39.707 0 97  ARG A NH1 1 ? 
ATOM   731  N  NH2 . ARG A 1 97  ? 41.918 -3.204  47.211 1.000 37.278 0 97  ARG A NH2 1 ? 
ATOM   732  N  N   . ALA A 1 98  ? 36.038 -2.816  52.245 1.000 18.609 0 98  ALA A N   1 ? 
ATOM   733  C  CA  . ALA A 1 98  ? 36.572 -2.596  53.566 1.000 18.020 0 98  ALA A CA  1 ? 
ATOM   734  C  C   . ALA A 1 98  ? 35.938 -3.555  54.577 1.000 22.695 0 98  ALA A C   1 ? 
ATOM   735  O  O   . ALA A 1 98  ? 36.541 -3.793  55.606 1.000 24.023 0 98  ALA A O   1 ? 
ATOM   736  C  CB  . ALA A 1 98  ? 36.355 -1.159  53.981 1.000 19.619 0 98  ALA A CB  1 ? 
ATOM   737  N  N   . MET A 1 99  ? 34.747 -4.092  54.308 1.000 20.103 0 99  MET A N   1 ? 
ATOM   738  C  CA  . MET A 1 99  ? 34.032 -4.897  55.281 1.000 21.677 0 99  MET A CA  1 ? 
ATOM   739  C  C   . MET A 1 99  ? 33.942 -6.362  54.868 1.000 29.856 0 99  MET A C   1 ? 
ATOM   740  O  O   . MET A 1 99  ? 33.613 -7.193  55.721 1.000 30.592 0 99  MET A O   1 ? 
ATOM   741  C  CB  . MET A 1 99  ? 32.630 -4.339  55.478 1.000 22.921 0 99  MET A CB  1 ? 
ATOM   742  C  CG  . MET A 1 99  ? 32.688 -3.059  56.275 1.000 21.134 0 99  MET A CG  1 ? 
ATOM   743  S  SD  . MET A 1 99  ? 31.134 -2.303  56.734 1.000 23.368 0 99  MET A SD  1 ? 
ATOM   744  C  CE  . MET A 1 99  ? 30.573 -1.599  55.176 1.000 21.381 0 99  MET A CE  1 ? 
ATOM   745  N  N   . LYS A 1 100 ? 34.250 -6.675  53.611 1.000 31.318 0 100 LYS A N   1 ? 
ATOM   746  C  CA  . LYS A 1 100 ? 34.046 -8.026  53.110 1.000 40.212 0 100 LYS A CA  1 ? 
ATOM   747  C  C   . LYS A 1 100 ? 35.078 -8.974  53.726 1.000 42.577 0 100 LYS A C   1 ? 
ATOM   748  O  O   . LYS A 1 100 ? 36.270 -8.675  53.740 1.000 43.904 0 100 LYS A O   1 ? 
ATOM   749  C  CB  . LYS A 1 100 ? 34.153 -8.065  51.580 1.000 44.622 0 100 LYS A CB  1 ? 
ATOM   750  C  CG  . LYS A 1 100 ? 33.308 -9.166  50.943 1.000 49.716 0 100 LYS A CG  1 ? 
ATOM   751  C  CD  . LYS A 1 100 ? 33.133 -8.997  49.440 1.000 54.783 0 100 LYS A CD  1 ? 
ATOM   752  C  CE  . LYS A 1 100 ? 31.868 -9.621  48.960 1.000 63.042 0 100 LYS A CE  1 ? 
ATOM   753  N  NZ  . LYS A 1 100 ? 31.745 -11.008 49.423 1.000 64.588 0 100 LYS A NZ  1 ? 
ATOM   754  N  N   . GLY A 1 101 ? 34.597 -10.129 54.219 1.000 50.965 0 101 GLY A N   1 ? 
ATOM   755  C  CA  . GLY A 1 101 ? 35.429 -11.103 54.914 1.000 44.214 0 101 GLY A CA  1 ? 
ATOM   756  C  C   . GLY A 1 101 ? 35.431 -10.892 56.431 1.000 38.582 0 101 GLY A C   1 ? 
ATOM   757  O  O   . GLY A 1 101 ? 34.794 -9.964  56.945 1.000 32.690 0 101 GLY A O   1 ? 
ATOM   758  N  N   . ALA A 1 102 ? 36.197 -11.757 57.121 1.000 34.054 0 102 ALA A N   1 ? 
ATOM   759  C  CA  . ALA A 1 102 ? 36.452 -11.665 58.552 1.000 35.662 0 102 ALA A CA  1 ? 
ATOM   760  C  C   . ALA A 1 102 ? 37.192 -10.387 58.968 1.000 37.903 0 102 ALA A C   1 ? 
ATOM   761  O  O   . ALA A 1 102 ? 37.004 -9.940  60.093 1.000 41.517 0 102 ALA A O   1 ? 
ATOM   762  C  CB  . ALA A 1 102 ? 37.190 -12.907 59.040 1.000 35.108 0 102 ALA A CB  1 ? 
ATOM   763  N  N   . GLY A 1 103 ? 38.023 -9.791  58.107 1.000 35.678 0 103 GLY A N   1 ? 
ATOM   764  C  CA  . GLY A 1 103 ? 38.749 -8.579  58.495 1.000 39.224 0 103 GLY A CA  1 ? 
ATOM   765  C  C   . GLY A 1 103 ? 37.912 -7.299  58.294 1.000 37.835 0 103 GLY A C   1 ? 
ATOM   766  O  O   . GLY A 1 103 ? 36.772 -7.354  57.844 1.000 38.986 0 103 GLY A O   1 ? 
ATOM   767  N  N   . THR A 1 104 ? 38.486 -6.149  58.668 1.000 30.593 0 104 THR A N   1 ? 
ATOM   768  C  CA  . THR A 1 104 ? 37.908 -4.841  58.382 1.000 30.403 0 104 THR A CA  1 ? 
ATOM   769  C  C   . THR A 1 104 ? 39.017 -3.845  58.074 1.000 28.602 0 104 THR A C   1 ? 
ATOM   770  O  O   . THR A 1 104 ? 39.941 -3.695  58.873 1.000 29.907 0 104 THR A O   1 ? 
ATOM   771  C  CB  . THR A 1 104 ? 37.130 -4.321  59.592 1.000 31.313 0 104 THR A CB  1 ? 
ATOM   772  O  OG1 . THR A 1 104 ? 36.179 -5.344  59.861 1.000 35.811 0 104 THR A OG1 1 ? 
ATOM   773  C  CG2 . THR A 1 104 ? 36.388 -3.024  59.312 1.000 31.093 0 104 THR A CG2 1 ? 
ATOM   774  N  N   . ASP A 1 105 ? 38.841 -3.044  57.015 1.000 23.044 0 105 ASP A N   1 ? 
ATOM   775  C  CA  . ASP A 1 105 ? 39.678 -1.865  56.816 1.000 23.230 0 105 ASP A CA  1 ? 
ATOM   776  C  C   . ASP A 1 105 ? 39.079 -0.640  57.533 1.000 23.109 0 105 ASP A C   1 ? 
ATOM   777  O  O   . ASP A 1 105 ? 38.398 0.176   56.920 1.000 19.417 0 105 ASP A O   1 ? 
ATOM   778  C  CB  . ASP A 1 105 ? 39.857 -1.608  55.334 1.000 23.854 0 105 ASP A CB  1 ? 
ATOM   779  C  CG  . ASP A 1 105 ? 40.813 -0.496  54.945 1.000 24.627 0 105 ASP A CG  1 ? 
ATOM   780  O  OD1 . ASP A 1 105 ? 41.260 0.207   55.863 1.000 21.748 0 105 ASP A OD1 1 ? 
ATOM   781  O  OD2 . ASP A 1 105 ? 41.162 -0.378  53.755 1.000 25.198 0 105 ASP A OD2 1 ? 
ATOM   782  N  N   . GLU A 1 106 ? 39.433 -0.466  58.821 1.000 21.094 0 106 GLU A N   1 ? 
ATOM   783  C  CA  . GLU A 1 106 ? 38.868 0.566   59.667 1.000 22.518 0 106 GLU A CA  1 ? 
ATOM   784  C  C   . GLU A 1 106 ? 39.227 1.962   59.145 1.000 19.969 0 106 GLU A C   1 ? 
ATOM   785  O  O   . GLU A 1 106 ? 38.385 2.864   59.191 1.000 20.357 0 106 GLU A O   1 ? 
ATOM   786  C  CB  . GLU A 1 106 ? 39.369 0.375   61.103 1.000 24.692 0 106 GLU A CB  1 ? 
ATOM   787  C  CG  . GLU A 1 106 ? 38.941 -0.965  61.694 1.000 30.704 0 106 GLU A CG  1 ? 
ATOM   788  C  CD  . GLU A 1 106 ? 38.950 -1.023  63.216 1.000 36.631 0 106 GLU A CD  1 ? 
ATOM   789  O  OE1 . GLU A 1 106 ? 39.873 -0.428  63.817 1.000 41.835 0 106 GLU A OE1 1 ? 
ATOM   790  O  OE2 . GLU A 1 106 ? 38.027 -1.661  63.789 1.000 45.471 0 106 GLU A OE2 1 ? 
ATOM   791  N  N   . GLY A 1 107 ? 40.445 2.128   58.591 1.000 20.721 0 107 GLY A N   1 ? 
ATOM   792  C  CA  . GLY A 1 107 ? 40.900 3.431   58.117 1.000 19.224 0 107 GLY A CA  1 ? 
ATOM   793  C  C   . GLY A 1 107 ? 40.034 3.925   56.958 1.000 16.888 0 107 GLY A C   1 ? 
ATOM   794  O  O   . GLY A 1 107 ? 39.701 5.110   56.884 1.000 18.337 0 107 GLY A O   1 ? 
ATOM   795  N  N   . CYS A 1 108 ? 39.647 2.990   56.077 1.000 17.057 0 108 CYS A N   1 ? 
ATOM   796  C  CA  . CYS A 1 108 ? 38.804 3.315   54.944 1.000 17.251 0 108 CYS A CA  1 ? 
ATOM   797  C  C   . CYS A 1 108 ? 37.420 3.774   55.418 1.000 15.458 0 108 CYS A C   1 ? 
ATOM   798  O  O   . CYS A 1 108 ? 36.898 4.768   54.961 1.000 15.967 0 108 CYS A O   1 ? 
ATOM   799  C  CB  . CYS A 1 108 ? 38.625 2.120   54.030 1.000 15.963 0 108 CYS A CB  1 ? 
ATOM   800  S  SG  . CYS A 1 108 ? 37.518 2.460   52.649 1.000 18.755 0 108 CYS A SG  1 ? 
ATOM   801  N  N   . LEU A 1 109 ? 36.828 3.053   56.361 1.000 15.370 0 109 LEU A N   1 ? 
ATOM   802  C  CA  . LEU A 1 109 ? 35.550 3.405   56.917 1.000 14.857 0 109 LEU A CA  1 ? 
ATOM   803  C  C   . LEU A 1 109 ? 35.586 4.801   57.537 1.000 14.161 0 109 LEU A C   1 ? 
ATOM   804  O  O   . LEU A 1 109 ? 34.668 5.569   57.312 1.000 15.909 0 109 LEU A O   1 ? 
ATOM   805  C  CB  . LEU A 1 109 ? 35.164 2.355   57.947 1.000 16.164 0 109 LEU A CB  1 ? 
ATOM   806  C  CG  . LEU A 1 109 ? 35.016 0.907   57.493 1.000 16.683 0 109 LEU A CG  1 ? 
ATOM   807  C  CD1 . LEU A 1 109 ? 34.443 0.108   58.674 1.000 18.385 0 109 LEU A CD1 1 ? 
ATOM   808  C  CD2 . LEU A 1 109 ? 34.150 0.779   56.267 1.000 18.130 0 109 LEU A CD2 1 ? 
ATOM   809  N  N   . ILE A 1 110 ? 36.630 5.069   58.342 1.000 15.164 0 110 ILE A N   1 ? 
ATOM   810  C  CA  . ILE A 1 110 ? 36.731 6.369   58.971 1.000 16.094 0 110 ILE A CA  1 ? 
ATOM   811  C  C   . ILE A 1 110 ? 36.775 7.442   57.890 1.000 16.545 0 110 ILE A C   1 ? 
ATOM   812  O  O   . ILE A 1 110 ? 36.106 8.488   57.988 1.000 14.853 0 110 ILE A O   1 ? 
ATOM   813  C  CB  . ILE A 1 110 ? 37.957 6.408   59.911 1.000 17.527 0 110 ILE A CB  1 ? 
ATOM   814  C  CG1 . ILE A 1 110 ? 37.772 5.501   61.092 1.000 21.048 0 110 ILE A CG1 1 ? 
ATOM   815  C  CG2 . ILE A 1 110 ? 38.308 7.816   60.389 1.000 19.811 0 110 ILE A CG2 1 ? 
ATOM   816  C  CD1 . ILE A 1 110 ? 39.023 5.355   61.940 1.000 24.488 0 110 ILE A CD1 1 ? 
ATOM   817  N  N   . GLU A 1 111 ? 37.712 7.230   56.943 1.000 15.377 0 111 GLU A N   1 ? 
ATOM   818  C  CA  . GLU A 1 111 ? 37.966 8.260   55.940 1.000 15.819 0 111 GLU A CA  1 ? 
ATOM   819  C  C   . GLU A 1 111 ? 36.696 8.625   55.173 1.000 15.604 0 111 GLU A C   1 ? 
ATOM   820  O  O   . GLU A 1 111 ? 36.407 9.812   54.994 1.000 15.629 0 111 GLU A O   1 ? 
ATOM   821  C  CB  . GLU A 1 111 ? 39.066 7.750   55.010 1.000 16.711 0 111 GLU A CB  1 ? 
ATOM   822  C  CG  . GLU A 1 111 ? 39.419 8.714   53.896 1.000 17.706 0 111 GLU A CG  1 ? 
ATOM   823  C  CD  . GLU A 1 111 ? 40.257 7.941   52.867 1.000 19.713 0 111 GLU A CD  1 ? 
ATOM   824  O  OE1 . GLU A 1 111 ? 41.248 7.255   53.220 1.000 23.378 0 111 GLU A OE1 1 ? 
ATOM   825  O  OE2 . GLU A 1 111 ? 39.752 7.864   51.723 1.000 22.095 0 111 GLU A OE2 1 ? 
ATOM   826  N  N   . ILE A 1 112 ? 35.942 7.656   54.665 1.000 14.848 0 112 ILE A N   1 ? 
ATOM   827  C  CA  . ILE A 1 112 ? 34.786 7.939   53.843 1.000 15.236 0 112 ILE A CA  1 ? 
ATOM   828  C  C   . ILE A 1 112 ? 33.704 8.569   54.740 1.000 15.211 0 112 ILE A C   1 ? 
ATOM   829  O  O   . ILE A 1 112 ? 33.120 9.579   54.395 1.000 17.018 0 112 ILE A O   1 ? 
ATOM   830  C  CB  . ILE A 1 112 ? 34.327 6.694   53.053 1.000 14.951 0 112 ILE A CB  1 ? 
ATOM   831  C  CG1 . ILE A 1 112 ? 35.407 6.316   52.012 1.000 14.960 0 112 ILE A CG1 1 ? 
ATOM   832  C  CG2 . ILE A 1 112 ? 32.996 6.945   52.346 1.000 15.669 0 112 ILE A CG2 1 ? 
ATOM   833  C  CD1 . ILE A 1 112 ? 35.080 5.019   51.302 1.000 15.391 0 112 ILE A CD1 1 ? 
ATOM   834  N  N   . LEU A 1 113 ? 33.416 7.956   55.886 1.000 14.956 0 113 LEU A N   1 ? 
ATOM   835  C  CA  . LEU A 1 113 ? 32.268 8.325   56.685 1.000 14.116 0 113 LEU A CA  1 ? 
ATOM   836  C  C   . LEU A 1 113 ? 32.478 9.680   57.364 1.000 15.357 0 113 LEU A C   1 ? 
ATOM   837  O  O   . LEU A 1 113 ? 31.484 10.364  57.640 1.000 16.251 0 113 LEU A O   1 ? 
ATOM   838  C  CB  . LEU A 1 113 ? 31.971 7.203   57.668 1.000 15.118 0 113 LEU A CB  1 ? 
ATOM   839  C  CG  . LEU A 1 113 ? 31.538 5.870   57.055 1.000 18.577 0 113 LEU A CG  1 ? 
ATOM   840  C  CD1 . LEU A 1 113 ? 31.342 4.832   58.122 1.000 21.398 0 113 LEU A CD1 1 ? 
ATOM   841  C  CD2 . LEU A 1 113 ? 30.279 6.072   56.279 1.000 21.551 0 113 LEU A CD2 1 ? 
ATOM   842  N  N   . ALA A 1 114 ? 33.737 10.028  57.704 1.000 14.355 0 114 ALA A N   1 ? 
ATOM   843  C  CA  . ALA A 1 114 ? 34.025 11.345  58.288 1.000 14.813 0 114 ALA A CA  1 ? 
ATOM   844  C  C   . ALA A 1 114 ? 34.071 12.465  57.250 1.000 18.541 0 114 ALA A C   1 ? 
ATOM   845  O  O   . ALA A 1 114 ? 33.780 13.639  57.580 1.000 19.625 0 114 ALA A O   1 ? 
ATOM   846  C  CB  . ALA A 1 114 ? 35.310 11.355  59.115 1.000 15.569 0 114 ALA A CB  1 ? 
ATOM   847  N  N   . SER A 1 115 ? 34.509 12.169  56.008 1.000 16.972 0 115 SER A N   1 ? 
ATOM   848  C  CA  . SER A 1 115 ? 34.768 13.242  55.059 1.000 15.865 0 115 SER A CA  1 ? 
ATOM   849  C  C   . SER A 1 115 ? 33.606 13.533  54.119 1.000 17.434 0 115 SER A C   1 ? 
ATOM   850  O  O   . SER A 1 115 ? 33.564 14.599  53.511 1.000 17.353 0 115 SER A O   1 ? 
ATOM   851  C  CB  . SER A 1 115 ? 35.933 12.917  54.208 1.000 15.005 0 115 SER A CB  1 ? 
ATOM   852  O  OG  . SER A 1 115 ? 35.700 11.778  53.380 1.000 15.104 0 115 SER A OG  1 ? 
ATOM   853  N  N   . ARG A 1 116 ? 32.645 12.620  53.993 1.000 17.682 0 116 ARG A N   1 ? 
ATOM   854  C  CA  . ARG A 1 116 ? 31.511 12.885  53.126 1.000 15.856 0 116 ARG A CA  1 ? 
ATOM   855  C  C   . ARG A 1 116 ? 30.427 13.659  53.885 1.000 16.678 0 116 ARG A C   1 ? 
ATOM   856  O  O   . ARG A 1 116 ? 30.270 13.547  55.094 1.000 19.195 0 116 ARG A O   1 ? 
ATOM   857  C  CB  . ARG A 1 116 ? 30.928 11.567  52.592 1.000 18.340 0 116 ARG A CB  1 ? 
ATOM   858  C  CG  . ARG A 1 116 ? 31.770 10.733  51.654 1.000 21.564 0 116 ARG A CG  1 ? 
ATOM   859  C  CD  . ARG A 1 116 ? 32.789 11.339  50.852 1.000 24.918 0 116 ARG A CD  1 ? 
ATOM   860  N  NE  . ARG A 1 116 ? 33.473 10.366  49.982 1.000 24.343 0 116 ARG A NE  1 ? 
ATOM   861  C  CZ  . ARG A 1 116 ? 34.738 10.075  49.960 1.000 19.999 0 116 ARG A CZ  1 ? 
ATOM   862  N  NH1 . ARG A 1 116 ? 35.614 10.557  50.837 1.000 20.426 0 116 ARG A NH1 1 ? 
ATOM   863  N  NH2 . ARG A 1 116 ? 35.206 9.281   49.025 1.000 21.288 0 116 ARG A NH2 1 ? 
ATOM   864  N  N   . THR A 1 117 ? 29.682 14.504  53.150 1.000 17.022 0 117 THR A N   1 ? 
ATOM   865  C  CA  . THR A 1 117 ? 28.594 15.216  53.773 1.000 17.070 0 117 THR A CA  1 ? 
ATOM   866  C  C   . THR A 1 117 ? 27.437 14.259  54.041 1.000 17.104 0 117 THR A C   1 ? 
ATOM   867  O  O   . THR A 1 117 ? 27.313 13.210  53.411 1.000 15.294 0 117 THR A O   1 ? 
ATOM   868  C  CB  . THR A 1 117 ? 28.068 16.356  52.900 1.000 19.007 0 117 THR A CB  1 ? 
ATOM   869  O  OG1 . THR A 1 117 ? 27.546 15.735  51.721 1.000 18.697 0 117 THR A OG1 1 ? 
ATOM   870  C  CG2 . THR A 1 117 ? 29.172 17.284  52.405 1.000 19.862 0 117 THR A CG2 1 ? 
ATOM   871  N  N   . PRO A 1 118 ? 26.507 14.628  54.931 1.000 16.702 0 118 PRO A N   1 ? 
ATOM   872  C  CA  . PRO A 1 118 ? 25.312 13.818  55.147 1.000 17.262 0 118 PRO A CA  1 ? 
ATOM   873  C  C   . PRO A 1 118 ? 24.557 13.507  53.864 1.000 15.387 0 118 PRO A C   1 ? 
ATOM   874  O  O   . PRO A 1 118 ? 24.079 12.376  53.682 1.000 17.985 0 118 PRO A O   1 ? 
ATOM   875  C  CB  . PRO A 1 118 ? 24.510 14.637  56.102 1.000 19.098 0 118 PRO A CB  1 ? 
ATOM   876  C  CG  . PRO A 1 118 ? 25.586 15.297  56.892 1.000 18.453 0 118 PRO A CG  1 ? 
ATOM   877  C  CD  . PRO A 1 118 ? 26.635 15.716  55.914 1.000 17.043 0 118 PRO A CD  1 ? 
ATOM   878  N  N   . GLU A 1 119 ? 24.444 14.499  52.984 1.000 15.685 0 119 GLU A N   1 ? 
ATOM   879  C  CA  . GLU A 1 119 ? 23.754 14.300  51.719 1.000 16.481 0 119 GLU A CA  1 ? 
ATOM   880  C  C   . GLU A 1 119 ? 24.494 13.256  50.871 1.000 17.564 0 119 GLU A C   1 ? 
ATOM   881  O  O   . GLU A 1 119 ? 23.851 12.398  50.231 1.000 17.387 0 119 GLU A O   1 ? 
ATOM   882  C  CB  . GLU A 1 119 ? 23.603 15.626  50.989 1.000 17.134 0 119 GLU A CB  1 ? 
ATOM   883  C  CG  . GLU A 1 119 ? 22.936 15.466  49.618 1.000 21.025 0 119 GLU A CG  1 ? 
ATOM   884  C  CD  . GLU A 1 119 ? 23.877 15.220  48.476 1.000 23.247 0 119 GLU A CD  1 ? 
ATOM   885  O  OE1 . GLU A 1 119 ? 25.064 15.556  48.443 1.000 28.492 0 119 GLU A OE1 1 ? 
ATOM   886  O  OE2 . GLU A 1 119 ? 23.327 14.595  47.552 1.000 33.509 0 119 GLU A OE2 1 ? 
ATOM   887  N  N   . GLU A 1 120 ? 25.841 13.257  50.891 1.000 17.863 0 120 GLU A N   1 ? 
ATOM   888  C  CA  . GLU A 1 120 ? 26.621 12.282  50.140 1.000 15.440 0 120 GLU A CA  1 ? 
ATOM   889  C  C   . GLU A 1 120 ? 26.439 10.912  50.769 1.000 15.340 0 120 GLU A C   1 ? 
ATOM   890  O  O   . GLU A 1 120 ? 26.312 9.912   50.033 1.000 17.056 0 120 GLU A O   1 ? 
ATOM   891  C  CB  . GLU A 1 120 ? 28.085 12.715  50.109 1.000 18.478 0 120 GLU A CB  1 ? 
ATOM   892  C  CG  . GLU A 1 120 ? 28.309 13.892  49.163 1.000 19.868 0 120 GLU A CG  1 ? 
ATOM   893  C  CD  . GLU A 1 120 ? 29.662 14.568  49.276 1.000 24.764 0 120 GLU A CD  1 ? 
ATOM   894  O  OE1 . GLU A 1 120 ? 30.354 14.383  50.282 1.000 20.752 0 120 GLU A OE1 1 ? 
ATOM   895  O  OE2 . GLU A 1 120 ? 30.031 15.322  48.354 1.000 25.306 0 120 GLU A OE2 1 ? 
ATOM   896  N  N   . ILE A 1 121 ? 26.473 10.864  52.100 1.000 15.875 0 121 ILE A N   1 ? 
ATOM   897  C  CA  . ILE A 1 121 ? 26.325 9.609   52.818 1.000 16.395 0 121 ILE A CA  1 ? 
ATOM   898  C  C   . ILE A 1 121 ? 24.968 8.962   52.496 1.000 16.487 0 121 ILE A C   1 ? 
ATOM   899  O  O   . ILE A 1 121 ? 24.871 7.733   52.313 1.000 15.325 0 121 ILE A O   1 ? 
ATOM   900  C  CB  . ILE A 1 121 ? 26.527 9.827   54.330 1.000 19.385 0 121 ILE A CB  1 ? 
ATOM   901  C  CG1 . ILE A 1 121 ? 27.994 10.147  54.644 1.000 22.546 0 121 ILE A CG1 1 ? 
ATOM   902  C  CG2 . ILE A 1 121 ? 26.013 8.629   55.136 1.000 21.268 0 121 ILE A CG2 1 ? 
ATOM   903  C  CD1 . ILE A 1 121 ? 28.897 8.945   54.614 1.000 26.254 0 121 ILE A CD1 1 ? 
ATOM   904  N  N   . ARG A 1 122 ? 23.913 9.754   52.379 1.000 16.485 0 122 ARG A N   1 ? 
ATOM   905  C  CA  . ARG A 1 122 ? 22.591 9.217   52.051 1.000 19.126 0 122 ARG A CA  1 ? 
ATOM   906  C  C   . ARG A 1 122 ? 22.613 8.590   50.663 1.000 19.011 0 122 ARG A C   1 ? 
ATOM   907  O  O   . ARG A 1 122 ? 22.152 7.465   50.533 1.000 18.854 0 122 ARG A O   1 ? 
ATOM   908  C  CB  . ARG A 1 122 ? 21.549 10.332  52.159 1.000 21.822 0 122 ARG A CB  1 ? 
ATOM   909  C  CG  . ARG A 1 122 ? 20.204 9.917   51.569 1.000 26.992 0 122 ARG A CG  1 ? 
ATOM   910  C  CD  . ARG A 1 122 ? 19.193 11.092  51.724 1.000 31.504 0 122 ARG A CD  1 ? 
ATOM   911  N  NE  . ARG A 1 122 ? 17.872 10.721  51.201 1.000 36.761 0 122 ARG A NE  1 ? 
ATOM   912  C  CZ  . ARG A 1 122 ? 17.481 11.003  49.980 1.000 34.162 0 122 ARG A CZ  1 ? 
ATOM   913  N  NH1 . ARG A 1 122 ? 18.241 11.746  49.197 1.000 39.734 0 122 ARG A NH1 1 ? 
ATOM   914  N  NH2 . ARG A 1 122 ? 16.358 10.493  49.532 1.000 38.426 0 122 ARG A NH2 1 ? 
ATOM   915  N  N   . ARG A 1 123 ? 23.314 9.186   49.675 1.000 16.118 0 123 ARG A N   1 ? 
ATOM   916  C  CA  . ARG A 1 123 ? 23.362 8.635   48.336 1.000 20.160 0 123 ARG A CA  1 ? 
ATOM   917  C  C   . ARG A 1 123 ? 24.170 7.324   48.360 1.000 16.190 0 123 ARG A C   1 ? 
ATOM   918  O  O   . ARG A 1 123 ? 23.795 6.334   47.743 1.000 16.208 0 123 ARG A O   1 ? 
ATOM   919  C  CB  . ARG A 1 123 ? 24.009 9.566   47.304 1.000 24.917 0 123 ARG A CB  1 ? 
ATOM   920  C  CG  . ARG A 1 123 ? 23.312 10.872  46.963 1.000 34.652 0 123 ARG A CG  1 ? 
ATOM   921  C  CD  . ARG A 1 123 ? 24.034 11.371  45.731 1.000 43.435 0 123 ARG A CD  1 ? 
ATOM   922  N  NE  . ARG A 1 123 ? 23.820 12.774  45.391 1.000 55.853 0 123 ARG A NE  1 ? 
ATOM   923  C  CZ  . ARG A 1 123 ? 24.387 13.341  44.330 1.000 66.326 0 123 ARG A CZ  1 ? 
ATOM   924  N  NH1 . ARG A 1 123 ? 25.297 12.674  43.627 1.000 66.288 0 123 ARG A NH1 1 ? 
ATOM   925  N  NH2 . ARG A 1 123 ? 24.057 14.578  43.990 1.000 64.386 0 123 ARG A NH2 1 ? 
ATOM   926  N  N   . ILE A 1 124 ? 25.240 7.320   49.158 1.000 16.216 0 124 ILE A N   1 ? 
ATOM   927  C  CA  . ILE A 1 124 ? 26.084 6.140   49.292 1.000 15.389 0 124 ILE A CA  1 ? 
ATOM   928  C  C   . ILE A 1 124 ? 25.296 5.021   49.937 1.000 15.098 0 124 ILE A C   1 ? 
ATOM   929  O  O   . ILE A 1 124 ? 25.303 3.872   49.478 1.000 14.556 0 124 ILE A O   1 ? 
ATOM   930  C  CB  . ILE A 1 124 ? 27.315 6.477   50.137 1.000 15.853 0 124 ILE A CB  1 ? 
ATOM   931  C  CG1 . ILE A 1 124 ? 28.289 7.354   49.324 1.000 14.804 0 124 ILE A CG1 1 ? 
ATOM   932  C  CG2 . ILE A 1 124 ? 27.965 5.169   50.591 1.000 15.516 0 124 ILE A CG2 1 ? 
ATOM   933  C  CD1 . ILE A 1 124 ? 29.325 8.074   50.163 1.000 16.470 0 124 ILE A CD1 1 ? 
ATOM   934  N  N   . SER A 1 125 ? 24.578 5.361   50.992 1.000 15.686 0 125 SER A N   1 ? 
ATOM   935  C  CA  . SER A 1 125 ? 23.805 4.364   51.735 1.000 17.194 0 125 SER A CA  1 ? 
ATOM   936  C  C   . SER A 1 125 ? 22.724 3.747   50.855 1.000 17.195 0 125 SER A C   1 ? 
ATOM   937  O  O   . SER A 1 125 ? 22.510 2.505   50.883 1.000 16.503 0 125 SER A O   1 ? 
ATOM   938  C  CB  . SER A 1 125 ? 23.173 5.035   52.945 1.000 20.133 0 125 SER A CB  1 ? 
ATOM   939  O  OG  . SER A 1 125 ? 22.551 4.038   53.750 1.000 20.613 0 125 SER A OG  1 ? 
ATOM   940  N  N   . GLN A 1 126 ? 22.024 4.595   50.098 1.000 17.158 0 126 GLN A N   1 ? 
ATOM   941  C  CA  . GLN A 1 126 ? 20.984 4.126   49.188 1.000 17.892 0 126 GLN A CA  1 ? 
ATOM   942  C  C   . GLN A 1 126 ? 21.548 3.207   48.116 1.000 18.056 0 126 GLN A C   1 ? 
ATOM   943  O  O   . GLN A 1 126 ? 20.965 2.165   47.775 1.000 15.848 0 126 GLN A O   1 ? 
ATOM   944  C  CB  . GLN A 1 126 ? 20.247 5.335   48.621 1.000 18.807 0 126 GLN A CB  1 ? 
ATOM   945  C  CG  . GLN A 1 126 ? 19.256 5.890   49.637 1.000 25.577 0 126 GLN A CG  1 ? 
ATOM   946  C  CD  . GLN A 1 126 ? 18.387 7.035   49.135 1.000 34.630 0 126 GLN A CD  1 ? 
ATOM   947  O  OE1 . GLN A 1 126 ? 18.564 7.558   48.038 1.000 45.541 0 126 GLN A OE1 1 ? 
ATOM   948  N  NE2 . GLN A 1 126 ? 17.456 7.458   49.977 1.000 42.006 0 126 GLN A NE2 1 ? 
ATOM   949  N  N   . THR A 1 127 ? 22.659 3.639   47.539 1.000 15.058 0 127 THR A N   1 ? 
ATOM   950  C  CA  . THR A 1 127 ? 23.294 2.881   46.486 1.000 15.272 0 127 THR A CA  1 ? 
ATOM   951  C  C   . THR A 1 127 ? 23.827 1.557   47.021 1.000 14.686 0 127 THR A C   1 ? 
ATOM   952  O  O   . THR A 1 127 ? 23.714 0.534   46.329 1.000 17.231 0 127 THR A O   1 ? 
ATOM   953  C  CB  . THR A 1 127 ? 24.386 3.691   45.792 1.000 18.206 0 127 THR A CB  1 ? 
ATOM   954  O  OG1 . THR A 1 127 ? 23.721 4.820   45.227 1.000 20.209 0 127 THR A OG1 1 ? 
ATOM   955  C  CG2 . THR A 1 127 ? 25.104 2.947   44.693 1.000 17.036 0 127 THR A CG2 1 ? 
ATOM   956  N  N   . TYR A 1 128 ? 24.415 1.553   48.218 1.000 15.705 0 128 TYR A N   1 ? 
ATOM   957  C  CA  . TYR A 1 128 ? 24.917 0.304   48.796 1.000 13.735 0 128 TYR A CA  1 ? 
ATOM   958  C  C   . TYR A 1 128 ? 23.733 -0.656  48.952 1.000 15.137 0 128 TYR A C   1 ? 
ATOM   959  O  O   . TYR A 1 128 ? 23.841 -1.854  48.666 1.000 14.596 0 128 TYR A O   1 ? 
ATOM   960  C  CB  . TYR A 1 128 ? 25.512 0.640   50.160 1.000 13.681 0 128 TYR A CB  1 ? 
ATOM   961  C  CG  . TYR A 1 128 ? 26.269 -0.427  50.922 1.000 14.270 0 128 TYR A CG  1 ? 
ATOM   962  C  CD1 . TYR A 1 128 ? 25.584 -1.338  51.713 1.000 14.757 0 128 TYR A CD1 1 ? 
ATOM   963  C  CD2 . TYR A 1 128 ? 27.664 -0.503  50.861 1.000 14.411 0 128 TYR A CD2 1 ? 
ATOM   964  C  CE1 . TYR A 1 128 ? 26.276 -2.257  52.472 1.000 15.498 0 128 TYR A CE1 1 ? 
ATOM   965  C  CE2 . TYR A 1 128 ? 28.352 -1.464  51.586 1.000 15.103 0 128 TYR A CE2 1 ? 
ATOM   966  C  CZ  . TYR A 1 128 ? 27.648 -2.360  52.369 1.000 16.796 0 128 TYR A CZ  1 ? 
ATOM   967  O  OH  . TYR A 1 128 ? 28.349 -3.325  53.076 1.000 20.928 0 128 TYR A OH  1 ? 
ATOM   968  N  N   . GLN A 1 129 ? 22.634 -0.176  49.508 1.000 15.497 0 129 GLN A N   1 ? 
ATOM   969  C  CA  . GLN A 1 129 ? 21.455 -1.019  49.690 1.000 15.823 0 129 GLN A CA  1 ? 
ATOM   970  C  C   . GLN A 1 129 ? 20.962 -1.591  48.368 1.000 14.995 0 129 GLN A C   1 ? 
ATOM   971  O  O   . GLN A 1 129 ? 20.716 -2.794  48.255 1.000 16.838 0 129 GLN A O   1 ? 
ATOM   972  C  CB  . GLN A 1 129 ? 20.331 -0.218  50.341 1.000 17.691 0 129 GLN A CB  1 ? 
ATOM   973  C  CG  . GLN A 1 129 ? 19.219 -1.091  50.883 1.000 19.485 0 129 GLN A CG  1 ? 
ATOM   974  C  CD  . GLN A 1 129 ? 19.412 -1.540  52.308 1.000 21.276 0 129 GLN A CD  1 ? 
ATOM   975  O  OE1 . GLN A 1 129 ? 19.144 -2.706  52.673 1.000 26.036 0 129 GLN A OE1 1 ? 
ATOM   976  N  NE2 . GLN A 1 129 ? 19.781 -0.575  53.131 1.000 17.773 0 129 GLN A NE2 1 ? 
ATOM   977  N  N   . GLN A 1 130 ? 20.904 -0.776  47.325 1.000 14.311 0 130 GLN A N   1 ? 
ATOM   978  C  CA  . GLN A 1 130 ? 20.391 -1.226  46.038 1.000 17.532 0 130 GLN A CA  1 ? 
ATOM   979  C  C   . GLN A 1 130 ? 21.298 -2.266  45.386 1.000 20.004 0 130 GLN A C   1 ? 
ATOM   980  O  O   . GLN A 1 130 ? 20.819 -3.264  44.803 1.000 17.350 0 130 GLN A O   1 ? 
ATOM   981  C  CB  . GLN A 1 130 ? 20.292 -0.062  45.054 1.000 19.590 0 130 GLN A CB  1 ? 
ATOM   982  C  CG  . GLN A 1 130 ? 19.102 0.858   45.240 1.000 30.634 0 130 GLN A CG  1 ? 
ATOM   983  C  CD  . GLN A 1 130 ? 18.993 1.862   44.103 1.000 37.212 0 130 GLN A CD  1 ? 
ATOM   984  O  OE1 . GLN A 1 130 ? 19.505 1.657   42.996 1.000 40.830 0 130 GLN A OE1 1 ? 
ATOM   985  N  NE2 . GLN A 1 130 ? 18.322 2.961   44.389 1.000 46.133 0 130 GLN A NE2 1 ? 
ATOM   986  N  N   . GLN A 1 131 ? 22.605 -2.046  45.507 1.000 18.391 0 131 GLN A N   1 ? 
ATOM   987  C  CA  . GLN A 1 131 ? 23.616 -2.903  44.896 1.000 17.002 0 131 GLN A CA  1 ? 
ATOM   988  C  C   . GLN A 1 131 ? 23.703 -4.252  45.589 1.000 18.046 0 131 GLN A C   1 ? 
ATOM   989  O  O   . GLN A 1 131 ? 23.819 -5.281  44.896 1.000 21.606 0 131 GLN A O   1 ? 
ATOM   990  C  CB  . GLN A 1 131 ? 24.990 -2.209  44.950 1.000 21.425 0 131 GLN A CB  1 ? 
ATOM   991  C  CG  . GLN A 1 131 ? 25.055 -1.028  43.996 1.000 22.665 0 131 GLN A CG  1 ? 
ATOM   992  C  CD  . GLN A 1 131 ? 25.179 -1.478  42.559 1.000 28.287 0 131 GLN A CD  1 ? 
ATOM   993  O  OE1 . GLN A 1 131 ? 26.002 -2.330  42.210 1.000 28.298 0 131 GLN A OE1 1 ? 
ATOM   994  N  NE2 . GLN A 1 131 ? 24.346 -0.906  41.717 1.000 31.092 0 131 GLN A NE2 1 ? 
ATOM   995  N  N   . TYR A 1 132 ? 23.775 -4.257  46.930 1.000 16.656 0 132 TYR A N   1 ? 
ATOM   996  C  CA  . TYR A 1 132 ? 24.088 -5.479  47.654 1.000 17.017 0 132 TYR A CA  1 ? 
ATOM   997  C  C   . TYR A 1 132 ? 22.884 -6.095  48.363 1.000 17.259 0 132 TYR A C   1 ? 
ATOM   998  O  O   . TYR A 1 132 ? 22.958 -7.247  48.833 1.000 18.621 0 132 TYR A O   1 ? 
ATOM   999  C  CB  . TYR A 1 132 ? 25.156 -5.197  48.703 1.000 16.401 0 132 TYR A CB  1 ? 
ATOM   1000 C  CG  . TYR A 1 132 ? 26.401 -4.617  48.067 1.000 17.068 0 132 TYR A CG  1 ? 
ATOM   1001 C  CD1 . TYR A 1 132 ? 27.126 -5.328  47.121 1.000 19.230 0 132 TYR A CD1 1 ? 
ATOM   1002 C  CD2 . TYR A 1 132 ? 26.880 -3.351  48.452 1.000 17.437 0 132 TYR A CD2 1 ? 
ATOM   1003 C  CE1 . TYR A 1 132 ? 28.254 -4.801  46.512 1.000 18.680 0 132 TYR A CE1 1 ? 
ATOM   1004 C  CE2 . TYR A 1 132 ? 28.000 -2.828  47.840 1.000 17.241 0 132 TYR A CE2 1 ? 
ATOM   1005 C  CZ  . TYR A 1 132 ? 28.675 -3.534  46.885 1.000 17.753 0 132 TYR A CZ  1 ? 
ATOM   1006 O  OH  . TYR A 1 132 ? 29.780 -2.964  46.298 1.000 20.602 0 132 TYR A OH  1 ? 
ATOM   1007 N  N   . GLY A 1 133 ? 21.794 -5.378  48.523 1.000 16.442 0 133 GLY A N   1 ? 
ATOM   1008 C  CA  . GLY A 1 133 ? 20.686 -5.883  49.325 1.000 17.088 0 133 GLY A CA  1 ? 
ATOM   1009 C  C   . GLY A 1 133 ? 21.080 -6.058  50.787 1.000 17.684 0 133 GLY A C   1 ? 
ATOM   1010 O  O   . GLY A 1 133 ? 20.514 -6.907  51.508 1.000 16.878 0 133 GLY A O   1 ? 
ATOM   1011 N  N   . ARG A 1 134 ? 21.936 -5.136  51.245 1.000 19.178 0 134 ARG A N   1 ? 
ATOM   1012 C  CA  . ARG A 1 134 ? 22.468 -5.128  52.599 1.000 19.762 0 134 ARG A CA  1 ? 
ATOM   1013 C  C   . ARG A 1 134 ? 22.405 -3.697  53.100 1.000 18.715 0 134 ARG A C   1 ? 
ATOM   1014 O  O   . ARG A 1 134 ? 22.523 -2.739  52.313 1.000 17.426 0 134 ARG A O   1 ? 
ATOM   1015 C  CB  . ARG A 1 134 ? 23.954 -5.553  52.612 1.000 23.357 0 134 ARG A CB  1 ? 
ATOM   1016 C  CG  . ARG A 1 134 ? 24.236 -6.961  52.106 1.000 26.065 0 134 ARG A CG  1 ? 
ATOM   1017 C  CD  . ARG A 1 134 ? 25.699 -7.306  52.009 1.000 23.321 0 134 ARG A CD  1 ? 
ATOM   1018 N  NE  . ARG A 1 134 ? 26.288 -7.365  53.356 1.000 23.879 0 134 ARG A NE  1 ? 
ATOM   1019 C  CZ  . ARG A 1 134 ? 26.574 -8.484  53.996 1.000 24.920 0 134 ARG A CZ  1 ? 
ATOM   1020 N  NH1 . ARG A 1 134 ? 26.395 -9.631  53.371 1.000 30.193 0 134 ARG A NH1 1 ? 
ATOM   1021 N  NH2 . ARG A 1 134 ? 26.970 -8.503  55.244 1.000 24.429 0 134 ARG A NH2 1 ? 
ATOM   1022 N  N   . SER A 1 135 ? 22.128 -3.517  54.386 1.000 19.720 0 135 SER A N   1 ? 
ATOM   1023 C  CA  . SER A 1 135 ? 22.186 -2.200  54.984 1.000 19.195 0 135 SER A CA  1 ? 
ATOM   1024 C  C   . SER A 1 135 ? 23.627 -1.792  55.314 1.000 17.686 0 135 SER A C   1 ? 
ATOM   1025 O  O   . SER A 1 135 ? 24.348 -2.530  55.968 1.000 17.565 0 135 SER A O   1 ? 
ATOM   1026 C  CB  . SER A 1 135 ? 21.304 -2.232  56.209 1.000 20.101 0 135 SER A CB  1 ? 
ATOM   1027 O  OG  . SER A 1 135 ? 21.660 -1.239  57.127 1.000 21.668 0 135 SER A OG  1 ? 
ATOM   1028 N  N   . LEU A 1 136 ? 24.019 -0.560  54.891 1.000 18.028 0 136 LEU A N   1 ? 
ATOM   1029 C  CA  . LEU A 1 136 ? 25.345 -0.060  55.209 1.000 18.256 0 136 LEU A CA  1 ? 
ATOM   1030 C  C   . LEU A 1 136 ? 25.500 0.036   56.732 1.000 18.212 0 136 LEU A C   1 ? 
ATOM   1031 O  O   . LEU A 1 136 ? 26.507 -0.434  57.273 1.000 16.136 0 136 LEU A O   1 ? 
ATOM   1032 C  CB  . LEU A 1 136 ? 25.579 1.282   54.515 1.000 17.174 0 136 LEU A CB  1 ? 
ATOM   1033 C  CG  . LEU A 1 136 ? 26.871 1.995   54.947 1.000 17.669 0 136 LEU A CG  1 ? 
ATOM   1034 C  CD1 . LEU A 1 136 ? 28.082 1.212   54.463 1.000 18.880 0 136 LEU A CD1 1 ? 
ATOM   1035 C  CD2 . LEU A 1 136 ? 26.922 3.391   54.382 1.000 18.588 0 136 LEU A CD2 1 ? 
ATOM   1036 N  N   . GLU A 1 137 ? 24.482 0.577   57.424 1.000 19.888 0 137 GLU A N   1 ? 
ATOM   1037 C  CA  . GLU A 1 137 ? 24.582 0.719   58.872 1.000 19.800 0 137 GLU A CA  1 ? 
ATOM   1038 C  C   . GLU A 1 137 ? 24.778 -0.652  59.522 1.000 19.243 0 137 GLU A C   1 ? 
ATOM   1039 O  O   . GLU A 1 137 ? 25.538 -0.807  60.468 1.000 20.559 0 137 GLU A O   1 ? 
ATOM   1040 C  CB  . GLU A 1 137 ? 23.300 1.407   59.330 1.000 24.560 0 137 GLU A CB  1 ? 
ATOM   1041 C  CG  . GLU A 1 137 ? 23.392 2.060   60.693 1.000 31.019 0 137 GLU A CG  1 ? 
ATOM   1042 C  CD  . GLU A 1 137 ? 22.077 2.737   61.027 1.000 30.151 0 137 GLU A CD  1 ? 
ATOM   1043 O  OE1 . GLU A 1 137 ? 21.653 2.553   62.174 1.000 42.956 0 137 GLU A OE1 1 ? 
ATOM   1044 O  OE2 . GLU A 1 137 ? 21.499 3.416   60.164 1.000 31.089 0 137 GLU A OE2 1 ? 
ATOM   1045 N  N   . ASP A 1 138 ? 24.001 -1.655  59.075 1.000 20.251 0 138 ASP A N   1 ? 
ATOM   1046 C  CA  . ASP A 1 138 ? 24.067 -2.966  59.696 1.000 21.198 0 138 ASP A CA  1 ? 
ATOM   1047 C  C   . ASP A 1 138 ? 25.435 -3.609  59.487 1.000 19.696 0 138 ASP A C   1 ? 
ATOM   1048 O  O   . ASP A 1 138 ? 26.014 -4.181  60.401 1.000 23.172 0 138 ASP A O   1 ? 
ATOM   1049 C  CB  . ASP A 1 138 ? 23.038 -3.931  59.098 1.000 23.748 0 138 ASP A CB  1 ? 
ATOM   1050 C  CG  . ASP A 1 138 ? 21.579 -3.693  59.470 1.000 29.204 0 138 ASP A CG  1 ? 
ATOM   1051 O  OD1 . ASP A 1 138 ? 21.290 -2.823  60.307 1.000 32.622 0 138 ASP A OD1 1 ? 
ATOM   1052 O  OD2 . ASP A 1 138 ? 20.721 -4.363  58.868 1.000 30.382 0 138 ASP A OD2 1 ? 
ATOM   1053 N  N   . ASP A 1 139 ? 26.029 -3.479  58.283 1.000 17.919 0 139 ASP A N   1 ? 
ATOM   1054 C  CA  . ASP A 1 139 ? 27.369 -3.968  58.016 1.000 18.400 0 139 ASP A CA  1 ? 
ATOM   1055 C  C   . ASP A 1 139 ? 28.421 -3.285  58.880 1.000 17.585 0 139 ASP A C   1 ? 
ATOM   1056 O  O   . ASP A 1 139 ? 29.329 -3.919  59.396 1.000 19.867 0 139 ASP A O   1 ? 
ATOM   1057 C  CB  . ASP A 1 139 ? 27.663 -3.922  56.520 1.000 18.591 0 139 ASP A CB  1 ? 
ATOM   1058 C  CG  . ASP A 1 139 ? 26.931 -5.002  55.740 1.000 21.727 0 139 ASP A CG  1 ? 
ATOM   1059 O  OD1 . ASP A 1 139 ? 26.316 -5.884  56.397 1.000 23.322 0 139 ASP A OD1 1 ? 
ATOM   1060 O  OD2 . ASP A 1 139 ? 26.906 -4.886  54.526 1.000 20.783 0 139 ASP A OD2 1 ? 
ATOM   1061 N  N   . ILE A 1 140 ? 28.333 -1.960  59.012 1.000 17.949 0 140 ILE A N   1 ? 
ATOM   1062 C  CA  . ILE A 1 140 ? 29.227 -1.221  59.889 1.000 18.080 0 140 ILE A CA  1 ? 
ATOM   1063 C  C   . ILE A 1 140 ? 29.124 -1.727  61.322 1.000 20.670 0 140 ILE A C   1 ? 
ATOM   1064 O  O   . ILE A 1 140 ? 30.140 -1.967  62.023 1.000 20.050 0 140 ILE A O   1 ? 
ATOM   1065 C  CB  . ILE A 1 140 ? 28.924 0.286   59.806 1.000 18.383 0 140 ILE A CB  1 ? 
ATOM   1066 C  CG1 . ILE A 1 140 ? 29.360 0.908   58.504 1.000 20.876 0 140 ILE A CG1 1 ? 
ATOM   1067 C  CG2 . ILE A 1 140 ? 29.633 0.991   60.982 1.000 19.944 0 140 ILE A CG2 1 ? 
ATOM   1068 C  CD1 . ILE A 1 140 ? 28.805 2.281   58.272 1.000 24.656 0 140 ILE A CD1 1 ? 
ATOM   1069 N  N   . ARG A 1 141 ? 27.882 -1.900  61.759 1.000 19.490 0 141 ARG A N   1 ? 
ATOM   1070 C  CA  . ARG A 1 141 ? 27.671 -2.360  63.121 1.000 24.519 0 141 ARG A CA  1 ? 
ATOM   1071 C  C   . ARG A 1 141 ? 28.352 -3.718  63.306 1.000 25.207 0 141 ARG A C   1 ? 
ATOM   1072 O  O   . ARG A 1 141 ? 28.996 -3.955  64.329 1.000 28.203 0 141 ARG A O   1 ? 
ATOM   1073 C  CB  . ARG A 1 141 ? 26.179 -2.238  63.457 1.000 27.499 0 141 ARG A CB  1 ? 
ATOM   1074 C  CG  . ARG A 1 141 ? 25.843 -2.624  64.888 1.000 32.618 0 141 ARG A CG  1 ? 
ATOM   1075 C  CD  . ARG A 1 141 ? 24.328 -2.568  65.096 1.000 30.768 0 141 ARG A CD  1 ? 
ATOM   1076 N  NE  . ARG A 1 141 ? 23.749 -1.285  64.676 1.000 35.249 0 141 ARG A NE  1 ? 
ATOM   1077 C  CZ  . ARG A 1 141 ? 22.923 -1.045  63.659 1.000 34.160 0 141 ARG A CZ  1 ? 
ATOM   1078 N  NH1 . ARG A 1 141 ? 22.535 -2.016  62.849 1.000 33.523 0 141 ARG A NH1 1 ? 
ATOM   1079 N  NH2 . ARG A 1 141 ? 22.431 0.172   63.483 1.000 31.786 0 141 ARG A NH2 1 ? 
ATOM   1080 N  N   . SER A 1 142 ? 28.294 -4.613  62.296 1.000 24.217 0 142 SER A N   1 ? 
ATOM   1081 C  CA  . SER A 1 142 ? 28.900 -5.933  62.427 1.000 23.904 0 142 SER A CA  1 ? 
ATOM   1082 C  C   . SER A 1 142 ? 30.423 -5.917  62.446 1.000 26.175 0 142 SER A C   1 ? 
ATOM   1083 O  O   . SER A 1 142 ? 31.049 -6.839  62.964 1.000 27.408 0 142 SER A O   1 ? 
ATOM   1084 C  CB  . SER A 1 142 ? 28.454 -6.874  61.330 1.000 28.799 0 142 SER A CB  1 ? 
ATOM   1085 O  OG  . SER A 1 142 ? 27.094 -7.214  61.525 1.000 35.794 0 142 SER A OG  1 ? 
ATOM   1086 N  N   . ASP A 1 143 ? 31.009 -4.947  61.749 1.000 22.460 0 143 ASP A N   1 ? 
ATOM   1087 C  CA  . ASP A 1 143 ? 32.425 -4.951  61.475 1.000 22.375 0 143 ASP A CA  1 ? 
ATOM   1088 C  C   . ASP A 1 143 ? 33.212 -4.139  62.491 1.000 24.238 0 143 ASP A C   1 ? 
ATOM   1089 O  O   . ASP A 1 143 ? 34.424 -4.091  62.366 1.000 27.635 0 143 ASP A O   1 ? 
ATOM   1090 C  CB  . ASP A 1 143 ? 32.671 -4.390  60.078 1.000 25.565 0 143 ASP A CB  1 ? 
ATOM   1091 C  CG  . ASP A 1 143 ? 33.091 -5.523  59.168 1.000 35.239 0 143 ASP A CG  1 ? 
ATOM   1092 O  OD1 . ASP A 1 143 ? 32.276 -6.470  59.070 1.000 38.978 0 143 ASP A OD1 1 ? 
ATOM   1093 O  OD2 . ASP A 1 143 ? 34.259 -5.486  58.698 1.000 38.338 0 143 ASP A OD2 1 ? 
ATOM   1094 N  N   . THR A 1 144 ? 32.512 -3.445  63.395 1.000 23.248 0 144 THR A N   1 ? 
ATOM   1095 C  CA  . THR A 1 144 ? 33.154 -2.593  64.384 1.000 25.488 0 144 THR A CA  1 ? 
ATOM   1096 C  C   . THR A 1 144 ? 32.491 -2.793  65.740 1.000 23.212 0 144 THR A C   1 ? 
ATOM   1097 O  O   . THR A 1 144 ? 31.408 -3.331  65.789 1.000 24.767 0 144 THR A O   1 ? 
ATOM   1098 C  CB  . THR A 1 144 ? 33.054 -1.135  63.921 1.000 25.024 0 144 THR A CB  1 ? 
ATOM   1099 O  OG1 . THR A 1 144 ? 31.699 -0.739  63.891 1.000 24.687 0 144 THR A OG1 1 ? 
ATOM   1100 C  CG2 . THR A 1 144 ? 33.649 -0.952  62.546 1.000 25.934 0 144 THR A CG2 1 ? 
ATOM   1101 N  N   . SER A 1 145 ? 33.143 -2.291  66.800 1.000 24.574 0 145 SER A N   1 ? 
ATOM   1102 C  CA  . SER A 1 145 ? 32.710 -2.562  68.163 1.000 25.235 0 145 SER A CA  1 ? 
ATOM   1103 C  C   . SER A 1 145 ? 32.817 -1.315  69.040 1.000 25.189 0 145 SER A C   1 ? 
ATOM   1104 O  O   . SER A 1 145 ? 33.560 -0.361  68.742 1.000 25.564 0 145 SER A O   1 ? 
ATOM   1105 C  CB  . SER A 1 145 ? 33.517 -3.733  68.748 1.000 25.845 0 145 SER A CB  1 ? 
ATOM   1106 O  OG  . SER A 1 145 ? 34.883 -3.372  68.878 1.000 28.398 0 145 SER A OG  1 ? 
ATOM   1107 N  N   . PHE A 1 146 ? 32.012 -1.340  70.109 1.000 23.817 0 146 PHE A N   1 ? 
ATOM   1108 C  CA  . PHE A 1 146 ? 32.103 -0.407  71.231 1.000 25.328 0 146 PHE A CA  1 ? 
ATOM   1109 C  C   . PHE A 1 146 ? 31.906 1.034   70.742 1.000 25.255 0 146 PHE A C   1 ? 
ATOM   1110 O  O   . PHE A 1 146 ? 31.007 1.297   69.943 1.000 22.209 0 146 PHE A O   1 ? 
ATOM   1111 C  CB  . PHE A 1 146 ? 33.419 -0.705  71.960 1.000 26.675 0 146 PHE A CB  1 ? 
ATOM   1112 C  CG  . PHE A 1 146 ? 33.506 -2.137  72.480 1.000 29.580 0 146 PHE A CG  1 ? 
ATOM   1113 C  CD1 . PHE A 1 146 ? 32.596 -2.597  73.434 1.000 33.394 0 146 PHE A CD1 1 ? 
ATOM   1114 C  CD2 . PHE A 1 146 ? 34.490 -3.004  72.029 1.000 34.518 0 146 PHE A CD2 1 ? 
ATOM   1115 C  CE1 . PHE A 1 146 ? 32.678 -3.903  73.925 1.000 36.714 0 146 PHE A CE1 1 ? 
ATOM   1116 C  CE2 . PHE A 1 146 ? 34.572 -4.311  72.531 1.000 33.962 0 146 PHE A CE2 1 ? 
ATOM   1117 C  CZ  . PHE A 1 146 ? 33.652 -4.755  73.452 1.000 36.250 0 146 PHE A CZ  1 ? 
ATOM   1118 N  N   . MET A 1 147 ? 32.729 1.945   71.270 1.000 23.248 0 147 MET A N   1 ? 
ATOM   1119 C  CA  . MET A 1 147 ? 32.518 3.360   71.013 1.000 24.005 0 147 MET A CA  1 ? 
ATOM   1120 C  C   . MET A 1 147 ? 32.820 3.709   69.550 1.000 20.748 0 147 MET A C   1 ? 
ATOM   1121 O  O   . MET A 1 147 ? 32.178 4.622   68.982 1.000 21.304 0 147 MET A O   1 ? 
ATOM   1122 C  CB  . MET A 1 147 ? 33.376 4.198   71.959 1.000 24.793 0 147 MET A CB  1 ? 
ATOM   1123 C  CG  . MET A 1 147 ? 33.003 4.063   73.417 1.000 28.490 0 147 MET A CG  1 ? 
ATOM   1124 S  SD  . MET A 1 147 ? 31.408 4.803   73.763 1.000 33.125 0 147 MET A SD  1 ? 
ATOM   1125 C  CE  . MET A 1 147 ? 30.057 3.750   73.254 1.000 35.206 0 147 MET A CE  1 ? 
ATOM   1126 N  N   . PHE A 1 148 ? 33.802 3.025   68.968 1.000 20.480 0 148 PHE A N   1 ? 
ATOM   1127 C  CA  . PHE A 1 148 ? 34.166 3.207   67.556 1.000 20.434 0 148 PHE A CA  1 ? 
ATOM   1128 C  C   . PHE A 1 148 ? 32.962 2.876   66.676 1.000 19.500 0 148 PHE A C   1 ? 
ATOM   1129 O  O   . PHE A 1 148 ? 32.566 3.631   65.808 1.000 20.791 0 148 PHE A O   1 ? 
ATOM   1130 C  CB  . PHE A 1 148 ? 35.420 2.387   67.249 1.000 21.772 0 148 PHE A CB  1 ? 
ATOM   1131 C  CG  . PHE A 1 148 ? 35.865 2.400   65.803 1.000 23.639 0 148 PHE A CG  1 ? 
ATOM   1132 C  CD1 . PHE A 1 148 ? 36.051 3.598   65.130 1.000 24.678 0 148 PHE A CD1 1 ? 
ATOM   1133 C  CD2 . PHE A 1 148 ? 36.020 1.216   65.085 1.000 23.447 0 148 PHE A CD2 1 ? 
ATOM   1134 C  CE1 . PHE A 1 148 ? 36.493 3.605   63.821 1.000 25.184 0 148 PHE A CE1 1 ? 
ATOM   1135 C  CE2 . PHE A 1 148 ? 36.467 1.238   63.774 1.000 23.638 0 148 PHE A CE2 1 ? 
ATOM   1136 C  CZ  . PHE A 1 148 ? 36.631 2.426   63.122 1.000 24.376 0 148 PHE A CZ  1 ? 
ATOM   1137 N  N   . GLN A 1 149 ? 32.295 1.735   66.947 1.000 21.382 0 149 GLN A N   1 ? 
ATOM   1138 C  CA  . GLN A 1 149 ? 31.060 1.387   66.254 1.000 21.622 0 149 GLN A CA  1 ? 
ATOM   1139 C  C   . GLN A 1 149 ? 30.015 2.503   66.368 1.000 21.925 0 149 GLN A C   1 ? 
ATOM   1140 O  O   . GLN A 1 149 ? 29.387 2.863   65.384 1.000 21.238 0 149 GLN A O   1 ? 
ATOM   1141 C  CB  . GLN A 1 149 ? 30.504 0.061   66.790 1.000 22.120 0 149 GLN A CB  1 ? 
ATOM   1142 C  CG  . GLN A 1 149 ? 29.157 -0.361  66.208 1.000 22.716 0 149 GLN A CG  1 ? 
ATOM   1143 C  CD  . GLN A 1 149 ? 28.491 -1.441  67.048 1.000 26.572 0 149 GLN A CD  1 ? 
ATOM   1144 O  OE1 . GLN A 1 149 ? 28.771 -2.655  66.940 1.000 28.700 0 149 GLN A OE1 1 ? 
ATOM   1145 N  NE2 . GLN A 1 149 ? 27.659 -1.017  67.980 1.000 27.891 0 149 GLN A NE2 1 ? 
ATOM   1146 N  N   . ARG A 1 150 ? 29.824 3.087   67.556 1.000 20.972 0 150 ARG A N   1 ? 
ATOM   1147 C  CA  . ARG A 1 150 ? 28.798 4.097   67.770 1.000 22.675 0 150 ARG A CA  1 ? 
ATOM   1148 C  C   . ARG A 1 150 ? 29.054 5.301   66.868 1.000 19.229 0 150 ARG A C   1 ? 
ATOM   1149 O  O   . ARG A 1 150 ? 28.127 5.821   66.246 1.000 20.191 0 150 ARG A O   1 ? 
ATOM   1150 C  CB  . ARG A 1 150 ? 28.731 4.521   69.242 1.000 27.111 0 150 ARG A CB  1 ? 
ATOM   1151 C  CG  . ARG A 1 150 ? 27.811 3.617   70.062 1.000 36.543 0 150 ARG A CG  1 ? 
ATOM   1152 C  CD  . ARG A 1 150 ? 27.321 4.294   71.365 1.000 33.957 0 150 ARG A CD  1 ? 
ATOM   1153 N  NE  . ARG A 1 150 ? 26.422 5.445   71.228 1.000 35.365 0 150 ARG A NE  1 ? 
ATOM   1154 C  CZ  . ARG A 1 150 ? 25.848 6.032   72.281 1.000 28.929 0 150 ARG A CZ  1 ? 
ATOM   1155 N  NH1 . ARG A 1 150 ? 26.302 5.726   73.456 1.000 28.977 0 150 ARG A NH1 1 ? 
ATOM   1156 N  NH2 . ARG A 1 150 ? 24.907 6.951   72.144 1.000 29.942 0 150 ARG A NH2 1 ? 
ATOM   1157 N  N   . VAL A 1 151 ? 30.332 5.689   66.770 1.000 18.294 0 151 VAL A N   1 ? 
ATOM   1158 C  CA  . VAL A 1 151 ? 30.677 6.812   65.918 1.000 18.967 0 151 VAL A CA  1 ? 
ATOM   1159 C  C   . VAL A 1 151 ? 30.345 6.460   64.472 1.000 18.150 0 151 VAL A C   1 ? 
ATOM   1160 O  O   . VAL A 1 151 ? 29.677 7.232   63.793 1.000 16.635 0 151 VAL A O   1 ? 
ATOM   1161 C  CB  . VAL A 1 151 ? 32.135 7.244   66.042 1.000 18.386 0 151 VAL A CB  1 ? 
ATOM   1162 C  CG1 . VAL A 1 151 ? 32.445 8.351   65.027 1.000 16.838 0 151 VAL A CG1 1 ? 
ATOM   1163 C  CG2 . VAL A 1 151 ? 32.445 7.663   67.454 1.000 18.825 0 151 VAL A CG2 1 ? 
ATOM   1164 N  N   . LEU A 1 152 ? 30.862 5.329   63.979 1.000 19.466 0 152 LEU A N   1 ? 
ATOM   1165 C  CA  . LEU A 1 152 ? 30.724 5.027   62.558 1.000 19.044 0 152 LEU A CA  1 ? 
ATOM   1166 C  C   . LEU A 1 152 ? 29.266 4.757   62.187 1.000 18.941 0 152 LEU A C   1 ? 
ATOM   1167 O  O   . LEU A 1 152 ? 28.798 5.164   61.131 1.000 19.531 0 152 LEU A O   1 ? 
ATOM   1168 C  CB  . LEU A 1 152 ? 31.623 3.856   62.163 1.000 19.158 0 152 LEU A CB  1 ? 
ATOM   1169 C  CG  . LEU A 1 152 ? 33.138 4.097   62.199 1.000 21.174 0 152 LEU A CG  1 ? 
ATOM   1170 C  CD1 . LEU A 1 152 ? 33.847 2.965   61.496 1.000 22.832 0 152 LEU A CD1 1 ? 
ATOM   1171 C  CD2 . LEU A 1 152 ? 33.521 5.445   61.609 1.000 25.046 0 152 LEU A CD2 1 ? 
ATOM   1172 N  N   . VAL A 1 153 ? 28.497 4.092   63.062 1.000 19.164 0 153 VAL A N   1 ? 
ATOM   1173 C  CA  . VAL A 1 153 ? 27.093 3.871   62.810 1.000 20.220 0 153 VAL A CA  1 ? 
ATOM   1174 C  C   . VAL A 1 153 ? 26.395 5.212   62.714 1.000 17.537 0 153 VAL A C   1 ? 
ATOM   1175 O  O   . VAL A 1 153 ? 25.664 5.476   61.789 1.000 20.577 0 153 VAL A O   1 ? 
ATOM   1176 C  CB  . VAL A 1 153 ? 26.476 2.973   63.899 1.000 18.929 0 153 VAL A CB  1 ? 
ATOM   1177 C  CG1 . VAL A 1 153 ? 24.965 3.048   63.847 1.000 21.469 0 153 VAL A CG1 1 ? 
ATOM   1178 C  CG2 . VAL A 1 153 ? 26.977 1.539   63.755 1.000 21.369 0 153 VAL A CG2 1 ? 
ATOM   1179 N  N   . SER A 1 154 ? 26.701 6.148   63.625 1.000 18.768 0 154 SER A N   1 ? 
ATOM   1180 C  CA  . SER A 1 154 ? 26.098 7.462   63.564 1.000 16.712 0 154 SER A CA  1 ? 
ATOM   1181 C  C   . SER A 1 154 ? 26.403 8.181   62.260 1.000 19.114 0 154 SER A C   1 ? 
ATOM   1182 O  O   . SER A 1 154 ? 25.523 8.747   61.613 1.000 19.888 0 154 SER A O   1 ? 
ATOM   1183 C  CB  . SER A 1 154 ? 26.561 8.324   64.739 1.000 19.509 0 154 SER A CB  1 ? 
ATOM   1184 O  OG  . SER A 1 154 ? 26.007 9.632   64.637 1.000 21.150 0 154 SER A OG  1 ? 
ATOM   1185 N  N   . LEU A 1 155 ? 27.661 8.127   61.834 1.000 16.837 0 155 LEU A N   1 ? 
ATOM   1186 C  CA  . LEU A 1 155 ? 27.999 8.830   60.622 1.000 16.293 0 155 LEU A CA  1 ? 
ATOM   1187 C  C   . LEU A 1 155 ? 27.284 8.179   59.433 1.000 16.437 0 155 LEU A C   1 ? 
ATOM   1188 O  O   . LEU A 1 155 ? 26.856 8.904   58.530 1.000 19.294 0 155 LEU A O   1 ? 
ATOM   1189 C  CB  . LEU A 1 155 ? 29.501 8.837   60.387 1.000 15.342 0 155 LEU A CB  1 ? 
ATOM   1190 C  CG  . LEU A 1 155 ? 30.395 9.573   61.402 1.000 15.056 0 155 LEU A CG  1 ? 
ATOM   1191 C  CD1 . LEU A 1 155 ? 31.867 9.354   61.128 1.000 13.599 0 155 LEU A CD1 1 ? 
ATOM   1192 C  CD2 . LEU A 1 155 ? 30.068 11.078  61.374 1.000 16.722 0 155 LEU A CD2 1 ? 
ATOM   1193 N  N   . SER A 1 156 ? 27.229 6.842   59.418 1.000 20.653 0 156 SER A N   1 ? 
ATOM   1194 C  CA  . SER A 1 156 ? 26.624 6.131   58.287 1.000 19.701 0 156 SER A CA  1 ? 
ATOM   1195 C  C   . SER A 1 156 ? 25.126 6.391   58.198 1.000 23.201 0 156 SER A C   1 ? 
ATOM   1196 O  O   . SER A 1 156 ? 24.531 6.231   57.132 1.000 21.257 0 156 SER A O   1 ? 
ATOM   1197 C  CB  . SER A 1 156 ? 26.906 4.657   58.353 1.000 21.034 0 156 SER A CB  1 ? 
ATOM   1198 O  OG  . SER A 1 156 ? 26.116 4.061   59.380 1.000 24.808 0 156 SER A OG  1 ? 
ATOM   1199 N  N   . ALA A 1 157 ? 24.504 6.731   59.332 1.000 24.768 0 157 ALA A N   1 ? 
ATOM   1200 C  CA  . ALA A 1 157 ? 23.076 6.995   59.414 1.000 26.708 0 157 ALA A CA  1 ? 
ATOM   1201 C  C   . ALA A 1 157 ? 22.772 8.374   58.835 1.000 32.151 0 157 ALA A C   1 ? 
ATOM   1202 O  O   . ALA A 1 157 ? 21.659 8.632   58.395 1.000 32.709 0 157 ALA A O   1 ? 
ATOM   1203 C  CB  . ALA A 1 157 ? 22.626 6.857   60.864 1.000 27.369 0 157 ALA A CB  1 ? 
ATOM   1204 N  N   . GLY A 1 158 ? 23.809 9.221   58.726 1.000 26.102 0 158 GLY A N   1 ? 
ATOM   1205 C  CA  . GLY A 1 158 ? 23.696 10.492  58.032 1.000 25.077 0 158 GLY A CA  1 ? 
ATOM   1206 C  C   . GLY A 1 158 ? 22.689 11.434  58.699 1.000 26.119 0 158 GLY A C   1 ? 
ATOM   1207 O  O   . GLY A 1 158 ? 22.124 12.307  58.014 1.000 25.360 0 158 GLY A O   1 ? 
ATOM   1208 N  N   . GLY A 1 159 ? 22.535 11.327  60.028 1.000 28.191 0 159 GLY A N   1 ? 
ATOM   1209 C  CA  . GLY A 1 159 ? 21.493 12.066  60.735 1.000 23.571 0 159 GLY A CA  1 ? 
ATOM   1210 C  C   . GLY A 1 159 ? 21.990 13.311  61.490 1.000 23.226 0 159 GLY A C   1 ? 
ATOM   1211 O  O   . GLY A 1 159 ? 21.241 13.872  62.288 1.000 24.269 0 159 GLY A O   1 ? 
ATOM   1212 N  N   . ARG A 1 160 ? 23.216 13.745  61.240 1.000 20.588 0 160 ARG A N   1 ? 
ATOM   1213 C  CA  . ARG A 1 160 ? 23.760 14.959  61.875 1.000 18.400 0 160 ARG A CA  1 ? 
ATOM   1214 C  C   . ARG A 1 160 ? 22.820 16.132  61.600 1.000 20.646 0 160 ARG A C   1 ? 
ATOM   1215 O  O   . ARG A 1 160 ? 22.211 16.260  60.528 1.000 21.444 0 160 ARG A O   1 ? 
ATOM   1216 C  CB  . ARG A 1 160 ? 25.147 15.239  61.295 1.000 19.221 0 160 ARG A CB  1 ? 
ATOM   1217 C  CG  . ARG A 1 160 ? 25.783 16.537  61.787 1.000 20.242 0 160 ARG A CG  1 ? 
ATOM   1218 C  CD  . ARG A 1 160 ? 27.086 16.775  60.977 1.000 19.848 0 160 ARG A CD  1 ? 
ATOM   1219 N  NE  . ARG A 1 160 ? 28.090 15.737  61.218 1.000 17.491 0 160 ARG A NE  1 ? 
ATOM   1220 C  CZ  . ARG A 1 160 ? 28.813 15.546  62.307 1.000 19.492 0 160 ARG A CZ  1 ? 
ATOM   1221 N  NH1 . ARG A 1 160 ? 28.639 16.317  63.372 1.000 18.914 0 160 ARG A NH1 1 ? 
ATOM   1222 N  NH2 . ARG A 1 160 ? 29.695 14.560  62.362 1.000 17.350 0 160 ARG A NH2 1 ? 
ATOM   1223 N  N   . ASP A 1 161 ? 22.701 17.037  62.559 1.000 18.142 0 161 ASP A N   1 ? 
ATOM   1224 C  CA  . ASP A 1 161 ? 22.090 18.329  62.278 1.000 18.678 0 161 ASP A CA  1 ? 
ATOM   1225 C  C   . ASP A 1 161 ? 22.715 18.988  61.043 1.000 19.144 0 161 ASP A C   1 ? 
ATOM   1226 O  O   . ASP A 1 161 ? 23.918 18.998  60.839 1.000 18.250 0 161 ASP A O   1 ? 
ATOM   1227 C  CB  . ASP A 1 161 ? 22.263 19.277  63.439 1.000 20.552 0 161 ASP A CB  1 ? 
ATOM   1228 C  CG  . ASP A 1 161 ? 21.530 18.936  64.725 1.000 24.852 0 161 ASP A CG  1 ? 
ATOM   1229 O  OD1 . ASP A 1 161 ? 20.679 18.044  64.706 1.000 26.796 0 161 ASP A OD1 1 ? 
ATOM   1230 O  OD2 . ASP A 1 161 ? 21.895 19.539  65.749 1.000 26.227 0 161 ASP A OD2 1 ? 
ATOM   1231 N  N   . GLU A 1 162 ? 21.840 19.589  60.229 1.000 20.985 0 162 GLU A N   1 ? 
ATOM   1232 C  CA  . GLU A 1 162 ? 22.268 20.247  59.007 1.000 22.643 0 162 GLU A CA  1 ? 
ATOM   1233 C  C   . GLU A 1 162 ? 21.982 21.743  59.107 1.000 23.321 0 162 GLU A C   1 ? 
ATOM   1234 O  O   . GLU A 1 162 ? 21.543 22.232  60.133 1.000 25.080 0 162 GLU A O   1 ? 
ATOM   1235 C  CB  . GLU A 1 162 ? 21.516 19.599  57.847 1.000 24.447 0 162 GLU A CB  1 ? 
ATOM   1236 C  CG  . GLU A 1 162 ? 21.784 18.098  57.793 1.000 29.356 0 162 GLU A CG  1 ? 
ATOM   1237 C  CD  . GLU A 1 162 ? 21.963 17.412  56.460 1.000 34.270 0 162 GLU A CD  1 ? 
ATOM   1238 O  OE1 . GLU A 1 162 ? 22.582 17.983  55.554 1.000 37.441 0 162 GLU A OE1 1 ? 
ATOM   1239 O  OE2 . GLU A 1 162 ? 21.610 16.197  56.432 1.000 38.412 0 162 GLU A OE2 1 ? 
ATOM   1240 N  N   . GLY A 1 163 ? 22.304 22.452  58.040 1.000 22.738 0 163 GLY A N   1 ? 
ATOM   1241 C  CA  . GLY A 1 163 ? 22.230 23.904  58.023 1.000 23.270 0 163 GLY A CA  1 ? 
ATOM   1242 C  C   . GLY A 1 163 ? 23.320 24.500  58.894 1.000 25.146 0 163 GLY A C   1 ? 
ATOM   1243 O  O   . GLY A 1 163 ? 24.257 23.807  59.253 1.000 22.237 0 163 GLY A O   1 ? 
ATOM   1244 N  N   . ASN A 1 164 ? 23.158 25.789  59.244 1.000 23.084 0 164 ASN A N   1 ? 
ATOM   1245 C  CA  . ASN A 1 164 ? 24.234 26.519  59.913 1.000 25.062 0 164 ASN A CA  1 ? 
ATOM   1246 C  C   . ASN A 1 164 ? 23.716 27.342  61.097 1.000 22.527 0 164 ASN A C   1 ? 
ATOM   1247 O  O   . ASN A 1 164 ? 24.411 28.252  61.560 1.000 23.465 0 164 ASN A O   1 ? 
ATOM   1248 C  CB  . ASN A 1 164 ? 25.080 27.378  58.973 1.000 25.036 0 164 ASN A CB  1 ? 
ATOM   1249 C  CG  . ASN A 1 164 ? 24.293 28.498  58.320 1.000 30.628 0 164 ASN A CG  1 ? 
ATOM   1250 O  OD1 . ASN A 1 164 ? 23.120 28.712  58.615 1.000 24.433 0 164 ASN A OD1 1 ? 
ATOM   1251 N  ND2 . ASN A 1 164 ? 24.941 29.260  57.448 1.000 39.867 0 164 ASN A ND2 1 ? 
ATOM   1252 N  N   . TYR A 1 165 ? 22.588 26.939  61.682 1.000 22.154 0 165 TYR A N   1 ? 
ATOM   1253 C  CA  . TYR A 1 165 ? 22.033 27.688  62.798 1.000 22.412 0 165 TYR A CA  1 ? 
ATOM   1254 C  C   . TYR A 1 165 ? 23.053 27.695  63.928 1.000 22.263 0 165 TYR A C   1 ? 
ATOM   1255 O  O   . TYR A 1 165 ? 23.591 26.661  64.302 1.000 20.934 0 165 TYR A O   1 ? 
ATOM   1256 C  CB  . TYR A 1 165 ? 20.699 27.102  63.267 1.000 23.549 0 165 TYR A CB  1 ? 
ATOM   1257 C  CG  . TYR A 1 165 ? 20.005 27.925  64.352 1.000 26.853 0 165 TYR A CG  1 ? 
ATOM   1258 C  CD1 . TYR A 1 165 ? 19.159 28.974  64.032 1.000 28.696 0 165 TYR A CD1 1 ? 
ATOM   1259 C  CD2 . TYR A 1 165 ? 20.225 27.662  65.701 1.000 28.258 0 165 TYR A CD2 1 ? 
ATOM   1260 C  CE1 . TYR A 1 165 ? 18.507 29.702  65.021 1.000 33.303 0 165 TYR A CE1 1 ? 
ATOM   1261 C  CE2 . TYR A 1 165 ? 19.602 28.395  66.692 1.000 29.585 0 165 TYR A CE2 1 ? 
ATOM   1262 C  CZ  . TYR A 1 165 ? 18.754 29.434  66.354 1.000 28.657 0 165 TYR A CZ  1 ? 
ATOM   1263 O  OH  . TYR A 1 165 ? 18.146 30.193  67.331 1.000 29.457 0 165 TYR A OH  1 ? 
ATOM   1264 N  N   . LEU A 1 166 ? 23.207 28.872  64.522 1.000 22.222 0 166 LEU A N   1 ? 
ATOM   1265 C  CA  . LEU A 1 166 ? 24.152 29.136  65.598 1.000 24.112 0 166 LEU A CA  1 ? 
ATOM   1266 C  C   . LEU A 1 166 ? 23.402 29.500  66.889 1.000 26.849 0 166 LEU A C   1 ? 
ATOM   1267 O  O   . LEU A 1 166 ? 22.911 30.622  67.069 1.000 25.495 0 166 LEU A O   1 ? 
ATOM   1268 C  CB  . LEU A 1 166 ? 25.131 30.241  65.214 1.000 27.125 0 166 LEU A CB  1 ? 
ATOM   1269 C  CG  . LEU A 1 166 ? 26.302 30.452  66.190 1.000 31.276 0 166 LEU A CG  1 ? 
ATOM   1270 C  CD1 . LEU A 1 166 ? 27.140 29.175  66.181 1.000 32.272 0 166 LEU A CD1 1 ? 
ATOM   1271 C  CD2 . LEU A 1 166 ? 27.181 31.678  65.864 1.000 33.949 0 166 LEU A CD2 1 ? 
ATOM   1272 N  N   . ASP A 1 167 ? 23.418 28.546  67.818 1.000 23.659 0 167 ASP A N   1 ? 
ATOM   1273 C  CA  . ASP A 1 167 ? 22.819 28.654  69.140 1.000 23.981 0 167 ASP A CA  1 ? 
ATOM   1274 C  C   . ASP A 1 167 ? 23.981 28.907  70.102 1.000 21.825 0 167 ASP A C   1 ? 
ATOM   1275 O  O   . ASP A 1 167 ? 24.701 27.996  70.504 1.000 22.117 0 167 ASP A O   1 ? 
ATOM   1276 C  CB  . ASP A 1 167 ? 22.030 27.388  69.400 1.000 21.274 0 167 ASP A CB  1 ? 
ATOM   1277 C  CG  . ASP A 1 167 ? 21.361 27.282  70.764 1.000 22.314 0 167 ASP A CG  1 ? 
ATOM   1278 O  OD1 . ASP A 1 167 ? 21.819 28.036  71.662 1.000 22.324 0 167 ASP A OD1 1 ? 
ATOM   1279 O  OD2 . ASP A 1 167 ? 20.476 26.418  70.876 1.000 25.681 0 167 ASP A OD2 1 ? 
ATOM   1280 N  N   . ASP A 1 168 ? 24.215 30.189  70.444 1.000 22.096 0 168 ASP A N   1 ? 
ATOM   1281 C  CA  . ASP A 1 168 ? 25.379 30.593  71.195 1.000 23.431 0 168 ASP A CA  1 ? 
ATOM   1282 C  C   . ASP A 1 168 ? 25.403 29.930  72.564 1.000 22.030 0 168 ASP A C   1 ? 
ATOM   1283 O  O   . ASP A 1 168 ? 26.486 29.578  73.031 1.000 19.722 0 168 ASP A O   1 ? 
ATOM   1284 C  CB  . ASP A 1 168 ? 25.427 32.108  71.346 1.000 28.774 0 168 ASP A CB  1 ? 
ATOM   1285 C  CG  . ASP A 1 168 ? 25.866 32.927  70.128 1.000 38.546 0 168 ASP A CG  1 ? 
ATOM   1286 O  OD1 . ASP A 1 168 ? 26.474 32.372  69.203 1.000 38.034 0 168 ASP A OD1 1 ? 
ATOM   1287 O  OD2 . ASP A 1 168 ? 25.585 34.151  70.120 1.000 42.672 0 168 ASP A OD2 1 ? 
ATOM   1288 N  N   . ALA A 1 169 ? 24.224 29.813  73.196 1.000 20.812 0 169 ALA A N   1 ? 
ATOM   1289 C  CA  . ALA A 1 169 ? 24.179 29.222  74.534 1.000 22.901 0 169 ALA A CA  1 ? 
ATOM   1290 C  C   . ALA A 1 169 ? 24.557 27.745  74.468 1.000 20.629 0 169 ALA A C   1 ? 
ATOM   1291 O  O   . ALA A 1 169 ? 25.295 27.265  75.328 1.000 22.137 0 169 ALA A O   1 ? 
ATOM   1292 C  CB  . ALA A 1 169 ? 22.824 29.372  75.206 1.000 23.325 0 169 ALA A CB  1 ? 
ATOM   1293 N  N   . LEU A 1 170 ? 24.111 27.059  73.414 1.000 21.203 0 170 LEU A N   1 ? 
ATOM   1294 C  CA  . LEU A 1 170 ? 24.422 25.642  73.299 1.000 19.745 0 170 LEU A CA  1 ? 
ATOM   1295 C  C   . LEU A 1 170 ? 25.900 25.423  72.952 1.000 18.727 0 170 LEU A C   1 ? 
ATOM   1296 O  O   . LEU A 1 170 ? 26.501 24.446  73.395 1.000 19.159 0 170 LEU A O   1 ? 
ATOM   1297 C  CB  . LEU A 1 170 ? 23.476 25.021  72.292 1.000 19.493 0 170 LEU A CB  1 ? 
ATOM   1298 C  CG  . LEU A 1 170 ? 23.601 23.497  72.144 1.000 22.779 0 170 LEU A CG  1 ? 
ATOM   1299 C  CD1 . LEU A 1 170 ? 23.210 22.812  73.469 1.000 27.281 0 170 LEU A CD1 1 ? 
ATOM   1300 C  CD2 . LEU A 1 170 ? 22.745 22.954  71.030 1.000 23.709 0 170 LEU A CD2 1 ? 
ATOM   1301 N  N   . VAL A 1 171 ? 26.508 26.340  72.181 1.000 21.689 0 171 VAL A N   1 ? 
ATOM   1302 C  CA  . VAL A 1 171 ? 27.926 26.256  71.880 1.000 20.279 0 171 VAL A CA  1 ? 
ATOM   1303 C  C   . VAL A 1 171 ? 28.696 26.317  73.202 1.000 20.856 0 171 VAL A C   1 ? 
ATOM   1304 O  O   . VAL A 1 171 ? 29.550 25.511  73.486 1.000 21.763 0 171 VAL A O   1 ? 
ATOM   1305 C  CB  . VAL A 1 171 ? 28.354 27.395  70.936 1.000 21.782 0 171 VAL A CB  1 ? 
ATOM   1306 C  CG1 . VAL A 1 171 ? 29.862 27.563  70.907 1.000 22.184 0 171 VAL A CG1 1 ? 
ATOM   1307 C  CG2 . VAL A 1 171 ? 27.732 27.267  69.546 1.000 21.988 0 171 VAL A CG2 1 ? 
ATOM   1308 N  N   . ARG A 1 172 ? 28.354 27.301  74.035 1.000 19.845 0 172 ARG A N   1 ? 
ATOM   1309 C  CA  . ARG A 1 172 ? 28.999 27.409  75.325 1.000 22.020 0 172 ARG A CA  1 ? 
ATOM   1310 C  C   . ARG A 1 172 ? 28.846 26.147  76.173 1.000 20.315 0 172 ARG A C   1 ? 
ATOM   1311 O  O   . ARG A 1 172 ? 29.830 25.742  76.825 1.000 21.965 0 172 ARG A O   1 ? 
ATOM   1312 C  CB  . ARG A 1 172 ? 28.437 28.620  76.078 1.000 26.609 0 172 ARG A CB  1 ? 
ATOM   1313 C  CG  . ARG A 1 172 ? 29.050 29.890  75.495 1.000 33.861 0 172 ARG A CG  1 ? 
ATOM   1314 C  CD  . ARG A 1 172 ? 28.873 31.096  76.442 1.000 40.943 0 172 ARG A CD  1 ? 
ATOM   1315 N  NE  . ARG A 1 172 ? 27.454 31.417  76.609 1.000 44.683 0 172 ARG A NE  1 ? 
ATOM   1316 C  CZ  . ARG A 1 172 ? 26.694 32.104  75.742 1.000 47.899 0 172 ARG A CZ  1 ? 
ATOM   1317 N  NH1 . ARG A 1 172 ? 27.226 32.675  74.666 1.000 52.263 0 172 ARG A NH1 1 ? 
ATOM   1318 N  NH2 . ARG A 1 172 ? 25.402 32.242  75.973 1.000 41.465 0 172 ARG A NH2 1 ? 
ATOM   1319 N  N   . GLN A 1 173 ? 27.618 25.616  76.214 1.000 21.637 0 173 GLN A N   1 ? 
ATOM   1320 C  CA  . GLN A 1 173 ? 27.317 24.446  77.024 1.000 21.381 0 173 GLN A CA  1 ? 
ATOM   1321 C  C   . GLN A 1 173 ? 28.108 23.245  76.505 1.000 23.180 0 173 GLN A C   1 ? 
ATOM   1322 O  O   . GLN A 1 173 ? 28.681 22.491  77.292 1.000 21.654 0 173 GLN A O   1 ? 
ATOM   1323 C  CB  . GLN A 1 173 ? 25.822 24.186  77.160 1.000 24.626 0 173 GLN A CB  1 ? 
ATOM   1324 C  CG  . GLN A 1 173 ? 25.478 22.910  77.929 1.000 31.984 0 173 GLN A CG  1 ? 
ATOM   1325 C  CD  . GLN A 1 173 ? 24.075 22.420  77.644 1.000 45.721 0 173 GLN A CD  1 ? 
ATOM   1326 O  OE1 . GLN A 1 173 ? 23.099 22.958  78.179 1.000 57.820 0 173 GLN A OE1 1 ? 
ATOM   1327 N  NE2 . GLN A 1 173 ? 23.943 21.407  76.786 1.000 46.664 0 173 GLN A NE2 1 ? 
ATOM   1328 N  N   . ASP A 1 174 ? 28.106 23.038  75.188 1.000 21.457 0 174 ASP A N   1 ? 
ATOM   1329 C  CA  . ASP A 1 174 ? 28.839 21.925  74.609 1.000 21.766 0 174 ASP A CA  1 ? 
ATOM   1330 C  C   . ASP A 1 174 ? 30.323 21.996  74.973 1.000 21.186 0 174 ASP A C   1 ? 
ATOM   1331 O  O   . ASP A 1 174 ? 30.914 21.004  75.365 1.000 20.351 0 174 ASP A O   1 ? 
ATOM   1332 C  CB  . ASP A 1 174 ? 28.635 21.901  73.092 1.000 21.494 0 174 ASP A CB  1 ? 
ATOM   1333 C  CG  . ASP A 1 174 ? 27.318 21.322  72.601 1.000 23.826 0 174 ASP A CG  1 ? 
ATOM   1334 O  OD1 . ASP A 1 174 ? 26.583 20.715  73.416 1.000 21.538 0 174 ASP A OD1 1 ? 
ATOM   1335 O  OD2 . ASP A 1 174 ? 26.997 21.482  71.401 1.000 22.005 0 174 ASP A OD2 1 ? 
ATOM   1336 N  N   . ALA A 1 175 ? 30.957 23.154  74.787 1.000 19.934 0 175 ALA A N   1 ? 
ATOM   1337 C  CA  . ALA A 1 175 ? 32.365 23.315  75.106 1.000 21.378 0 175 ALA A CA  1 ? 
ATOM   1338 C  C   . ALA A 1 175 ? 32.650 22.974  76.575 1.000 21.989 0 175 ALA A C   1 ? 
ATOM   1339 O  O   . ALA A 1 175 ? 33.549 22.190  76.881 1.000 22.829 0 175 ALA A O   1 ? 
ATOM   1340 C  CB  . ALA A 1 175 ? 32.804 24.736  74.783 1.000 21.663 0 175 ALA A CB  1 ? 
ATOM   1341 N  N   . GLN A 1 176 ? 31.811 23.493  77.462 1.000 21.802 0 176 GLN A N   1 ? 
ATOM   1342 C  CA  . GLN A 1 176 ? 31.959 23.194  78.886 1.000 23.789 0 176 GLN A CA  1 ? 
ATOM   1343 C  C   . GLN A 1 176 ? 31.794 21.698  79.163 1.000 24.139 0 176 GLN A C   1 ? 
ATOM   1344 O  O   . GLN A 1 176 ? 32.574 21.127  79.940 1.000 24.234 0 176 GLN A O   1 ? 
ATOM   1345 C  CB  . GLN A 1 176 ? 30.957 24.040  79.685 1.000 24.063 0 176 GLN A CB  1 ? 
ATOM   1346 C  CG  . GLN A 1 176 ? 31.096 23.887  81.196 1.000 29.775 0 176 GLN A CG  1 ? 
ATOM   1347 C  CD  . GLN A 1 176 ? 32.419 24.396  81.724 1.000 31.541 0 176 GLN A CD  1 ? 
ATOM   1348 O  OE1 . GLN A 1 176 ? 32.946 25.420  81.268 1.000 33.552 0 176 GLN A OE1 1 ? 
ATOM   1349 N  NE2 . GLN A 1 176 ? 32.972 23.691  82.701 1.000 38.414 0 176 GLN A NE2 1 ? 
ATOM   1350 N  N   . ASP A 1 177 ? 30.764 21.095  78.561 1.000 23.494 0 177 ASP A N   1 ? 
ATOM   1351 C  CA  . ASP A 1 177 ? 30.490 19.666  78.703 1.000 24.524 0 177 ASP A CA  1 ? 
ATOM   1352 C  C   . ASP A 1 177 ? 31.683 18.824  78.255 1.000 23.832 0 177 ASP A C   1 ? 
ATOM   1353 O  O   . ASP A 1 177 ? 32.022 17.836  78.897 1.000 24.219 0 177 ASP A O   1 ? 
ATOM   1354 C  CB  . ASP A 1 177 ? 29.228 19.265  77.968 1.000 23.676 0 177 ASP A CB  1 ? 
ATOM   1355 C  CG  . ASP A 1 177 ? 27.920 19.713  78.604 1.000 25.971 0 177 ASP A CG  1 ? 
ATOM   1356 O  OD1 . ASP A 1 177 ? 27.958 20.165  79.778 1.000 29.647 0 177 ASP A OD1 1 ? 
ATOM   1357 O  OD2 . ASP A 1 177 ? 26.880 19.612  77.940 1.000 28.097 0 177 ASP A OD2 1 ? 
ATOM   1358 N  N   . LEU A 1 178 ? 32.322 19.196  77.146 1.000 22.110 0 178 LEU A N   1 ? 
ATOM   1359 C  CA  . LEU A 1 178 ? 33.489 18.466  76.671 1.000 21.688 0 178 LEU A CA  1 ? 
ATOM   1360 C  C   . LEU A 1 178 ? 34.689 18.656  77.603 1.000 26.880 0 178 LEU A C   1 ? 
ATOM   1361 O  O   . LEU A 1 178 ? 35.457 17.714  77.763 1.000 25.936 0 178 LEU A O   1 ? 
ATOM   1362 C  CB  . LEU A 1 178 ? 33.857 18.895  75.253 1.000 21.644 0 178 LEU A CB  1 ? 
ATOM   1363 C  CG  . LEU A 1 178 ? 32.820 18.572  74.181 1.000 22.909 0 178 LEU A CG  1 ? 
ATOM   1364 C  CD1 . LEU A 1 178 ? 33.219 19.201  72.866 1.000 22.846 0 178 LEU A CD1 1 ? 
ATOM   1365 C  CD2 . LEU A 1 178 ? 32.651 17.067  74.016 1.000 25.675 0 178 LEU A CD2 1 ? 
ATOM   1366 N  N   . TYR A 1 179 ? 34.878 19.880  78.137 1.000 23.837 0 179 TYR A N   1 ? 
ATOM   1367 C  CA  . TYR A 1 179 ? 35.908 20.144  79.128 1.000 28.130 0 179 TYR A CA  1 ? 
ATOM   1368 C  C   . TYR A 1 179 ? 35.708 19.243  80.360 1.000 30.011 0 179 TYR A C   1 ? 
ATOM   1369 O  O   . TYR A 1 179 ? 36.643 18.539  80.772 1.000 26.368 0 179 TYR A O   1 ? 
ATOM   1370 C  CB  . TYR A 1 179 ? 35.916 21.644  79.436 1.000 30.288 0 179 TYR A CB  1 ? 
ATOM   1371 C  CG  . TYR A 1 179 ? 37.030 22.026  80.404 1.000 35.184 0 179 TYR A CG  1 ? 
ATOM   1372 C  CD1 . TYR A 1 179 ? 38.360 21.900  80.026 1.000 36.708 0 179 TYR A CD1 1 ? 
ATOM   1373 C  CD2 . TYR A 1 179 ? 36.751 22.431  81.702 1.000 44.154 0 179 TYR A CD2 1 ? 
ATOM   1374 C  CE1 . TYR A 1 179 ? 39.392 22.215  80.899 1.000 44.887 0 179 TYR A CE1 1 ? 
ATOM   1375 C  CE2 . TYR A 1 179 ? 37.772 22.740  82.591 1.000 49.793 0 179 TYR A CE2 1 ? 
ATOM   1376 C  CZ  . TYR A 1 179 ? 39.094 22.638  82.184 1.000 52.623 0 179 TYR A CZ  1 ? 
ATOM   1377 O  OH  . TYR A 1 179 ? 40.109 22.953  83.049 1.000 68.060 0 179 TYR A OH  1 ? 
ATOM   1378 N  N   . GLU A 1 180 ? 34.485 19.230  80.900 1.000 26.748 0 180 GLU A N   1 ? 
ATOM   1379 C  CA  . GLU A 1 180 ? 34.179 18.376  82.043 1.000 30.339 0 180 GLU A CA  1 ? 
ATOM   1380 C  C   . GLU A 1 180 ? 34.280 16.882  81.716 1.000 29.351 0 180 GLU A C   1 ? 
ATOM   1381 O  O   . GLU A 1 180 ? 34.640 16.073  82.564 1.000 30.306 0 180 GLU A O   1 ? 
ATOM   1382 C  CB  . GLU A 1 180 ? 32.789 18.742  82.557 1.000 30.419 0 180 GLU A CB  1 ? 
ATOM   1383 C  CG  . GLU A 1 180 ? 32.781 20.130  83.178 1.000 33.792 0 180 GLU A CG  1 ? 
ATOM   1384 C  CD  . GLU A 1 180 ? 31.407 20.564  83.626 1.000 39.364 0 180 GLU A CD  1 ? 
ATOM   1385 O  OE1 . GLU A 1 180 ? 30.485 19.712  83.620 1.000 49.021 0 180 GLU A OE1 1 ? 
ATOM   1386 O  OE2 . GLU A 1 180 ? 31.251 21.740  83.985 1.000 42.388 0 180 GLU A OE2 1 ? 
ATOM   1387 N  N   . ALA A 1 181 ? 33.898 16.481  80.503 1.000 25.620 0 181 ALA A N   1 ? 
ATOM   1388 C  CA  . ALA A 1 181 ? 33.982 15.076  80.138 1.000 25.669 0 181 ALA A CA  1 ? 
ATOM   1389 C  C   . ALA A 1 181 ? 35.418 14.575  80.251 1.000 30.474 0 181 ALA A C   1 ? 
ATOM   1390 O  O   . ALA A 1 181 ? 35.646 13.384  80.443 1.000 29.566 0 181 ALA A O   1 ? 
ATOM   1391 C  CB  . ALA A 1 181 ? 33.486 14.882  78.734 1.000 25.826 0 181 ALA A CB  1 ? 
ATOM   1392 N  N   . GLY A 1 182 ? 36.391 15.484  80.108 1.000 32.403 0 182 GLY A N   1 ? 
ATOM   1393 C  CA  . GLY A 1 182 ? 37.796 15.119  80.146 1.000 33.449 0 182 GLY A CA  1 ? 
ATOM   1394 C  C   . GLY A 1 182 ? 38.378 15.111  81.557 1.000 38.652 0 182 GLY A C   1 ? 
ATOM   1395 O  O   . GLY A 1 182 ? 39.516 14.695  81.736 1.000 45.288 0 182 GLY A O   1 ? 
ATOM   1396 N  N   . GLU A 1 183 ? 37.649 15.621  82.553 1.000 39.759 0 183 GLU A N   1 ? 
ATOM   1397 C  CA  . GLU A 1 183 ? 38.192 15.650  83.906 1.000 43.459 0 183 GLU A CA  1 ? 
ATOM   1398 C  C   . GLU A 1 183 ? 37.316 14.836  84.862 1.000 47.837 0 183 GLU A C   1 ? 
ATOM   1399 O  O   . GLU A 1 183 ? 37.372 15.039  86.074 1.000 52.069 0 183 GLU A O   1 ? 
ATOM   1400 C  CB  . GLU A 1 183 ? 38.430 17.089  84.364 1.000 48.188 0 183 GLU A CB  1 ? 
ATOM   1401 C  CG  . GLU A 1 183 ? 37.185 17.968  84.333 1.000 52.243 0 183 GLU A CG  1 ? 
ATOM   1402 C  CD  . GLU A 1 183 ? 37.494 19.453  84.278 1.000 59.316 0 183 GLU A CD  1 ? 
ATOM   1403 O  OE1 . GLU A 1 183 ? 38.690 19.809  84.304 1.000 70.435 0 183 GLU A OE1 1 ? 
ATOM   1404 O  OE2 . GLU A 1 183 ? 36.543 20.256  84.190 1.000 64.226 0 183 GLU A OE2 1 ? 
ATOM   1405 N  N   . LYS A 1 184 ? 36.530 13.900  84.311 1.000 48.945 0 184 LYS A N   1 ? 
ATOM   1406 C  CA  . LYS A 1 184 ? 35.661 13.046  85.109 1.000 53.791 0 184 LYS A CA  1 ? 
ATOM   1407 C  C   . LYS A 1 184 ? 36.576 12.031  85.785 1.000 47.578 0 184 LYS A C   1 ? 
ATOM   1408 O  O   . LYS A 1 184 ? 37.532 11.558  85.171 1.000 47.030 0 184 LYS A O   1 ? 
ATOM   1409 C  CB  . LYS A 1 184 ? 34.551 12.435  84.235 1.000 58.315 0 184 LYS A CB  1 ? 
ATOM   1410 C  CG  . LYS A 1 184 ? 33.500 11.623  84.982 1.000 66.008 0 184 LYS A CG  1 ? 
ATOM   1411 C  CD  . LYS A 1 184 ? 32.390 11.012  84.132 1.000 70.573 0 184 LYS A CD  1 ? 
ATOM   1412 C  CE  . LYS A 1 184 ? 31.510 10.101  84.940 1.000 68.112 0 184 LYS A CE  1 ? 
ATOM   1413 N  NZ  . LYS A 1 184 ? 30.261 9.767   84.251 1.000 66.460 0 184 LYS A NZ  1 ? 
ATOM   1414 N  N   . LYS A 1 185 ? 36.311 11.726  87.057 1.000 43.787 0 185 LYS A N   1 ? 
ATOM   1415 C  CA  . LYS A 1 185 ? 37.310 11.054  87.876 1.000 44.046 0 185 LYS A CA  1 ? 
ATOM   1416 C  C   . LYS A 1 185 ? 37.688 9.694   87.281 1.000 43.374 0 185 LYS A C   1 ? 
ATOM   1417 O  O   . LYS A 1 185 ? 38.864 9.335   87.316 1.000 42.125 0 185 LYS A O   1 ? 
ATOM   1418 C  CB  . LYS A 1 185 ? 36.874 10.888  89.342 1.000 43.873 0 185 LYS A CB  1 ? 
ATOM   1419 C  CG  . LYS A 1 185 ? 38.023 10.482  90.280 1.000 45.831 0 185 LYS A CG  1 ? 
ATOM   1420 C  CD  . LYS A 1 185 ? 37.631 10.165  91.721 1.000 50.187 0 185 LYS A CD  1 ? 
ATOM   1421 C  CE  . LYS A 1 185 ? 37.236 11.354  92.533 1.000 55.092 0 185 LYS A CE  1 ? 
ATOM   1422 N  NZ  . LYS A 1 185 ? 38.395 12.014  93.135 1.000 57.382 0 185 LYS A NZ  1 ? 
ATOM   1423 N  N   . TRP A 1 186 ? 36.702 8.910   86.808 1.000 39.448 0 186 TRP A N   1 ? 
ATOM   1424 C  CA  . TRP A 1 186 ? 36.950 7.512   86.444 1.000 46.873 0 186 TRP A CA  1 ? 
ATOM   1425 C  C   . TRP A 1 186 ? 36.849 7.294   84.935 1.000 48.458 0 186 TRP A C   1 ? 
ATOM   1426 O  O   . TRP A 1 186 ? 36.205 6.351   84.480 1.000 48.527 0 186 TRP A O   1 ? 
ATOM   1427 C  CB  . TRP A 1 186 ? 36.004 6.560   87.201 1.000 48.619 0 186 TRP A CB  1 ? 
ATOM   1428 C  CG  . TRP A 1 186 ? 36.307 6.536   88.674 1.000 45.681 0 186 TRP A CG  1 ? 
ATOM   1429 C  CD1 . TRP A 1 186 ? 35.511 6.967   89.695 1.000 43.667 0 186 TRP A CD1 1 ? 
ATOM   1430 C  CD2 . TRP A 1 186 ? 37.560 6.118   89.269 1.000 45.074 0 186 TRP A CD2 1 ? 
ATOM   1431 N  NE1 . TRP A 1 186 ? 36.180 6.841   90.884 1.000 40.124 0 186 TRP A NE1 1 ? 
ATOM   1432 C  CE2 . TRP A 1 186 ? 37.428 6.317   90.661 1.000 43.044 0 186 TRP A CE2 1 ? 
ATOM   1433 C  CE3 . TRP A 1 186 ? 38.763 5.592   88.763 1.000 45.663 0 186 TRP A CE3 1 ? 
ATOM   1434 C  CZ2 . TRP A 1 186 ? 38.457 6.004   91.551 1.000 41.446 0 186 TRP A CZ2 1 ? 
ATOM   1435 C  CZ3 . TRP A 1 186 ? 39.775 5.264   89.642 1.000 46.460 0 186 TRP A CZ3 1 ? 
ATOM   1436 C  CH2 . TRP A 1 186 ? 39.616 5.467   91.021 1.000 48.399 0 186 TRP A CH2 1 ? 
ATOM   1437 N  N   . GLY A 1 187 ? 37.538 8.147   84.174 1.000 42.918 0 187 GLY A N   1 ? 
ATOM   1438 C  CA  . GLY A 1 187 ? 37.650 7.985   82.738 1.000 42.404 0 187 GLY A CA  1 ? 
ATOM   1439 C  C   . GLY A 1 187 ? 36.852 9.071   82.023 1.000 37.833 0 187 GLY A C   1 ? 
ATOM   1440 O  O   . GLY A 1 187 ? 35.811 9.542   82.495 1.000 38.196 0 187 GLY A O   1 ? 
ATOM   1441 N  N   . THR A 1 188 ? 37.369 9.459   80.865 1.000 34.661 0 188 THR A N   1 ? 
ATOM   1442 C  CA  . THR A 1 188 ? 36.685 10.384  79.983 1.000 30.698 0 188 THR A CA  1 ? 
ATOM   1443 C  C   . THR A 1 188 ? 35.230 9.969   79.792 1.000 28.217 0 188 THR A C   1 ? 
ATOM   1444 O  O   . THR A 1 188 ? 34.938 8.796   79.540 1.000 28.652 0 188 THR A O   1 ? 
ATOM   1445 C  CB  . THR A 1 188 ? 37.393 10.302  78.641 1.000 30.280 0 188 THR A CB  1 ? 
ATOM   1446 O  OG1 . THR A 1 188 ? 38.768 10.436  78.962 1.000 31.630 0 188 THR A OG1 1 ? 
ATOM   1447 C  CG2 . THR A 1 188 ? 36.883 11.364  77.689 1.000 31.841 0 188 THR A CG2 1 ? 
ATOM   1448 N  N   . ASP A 1 189 ? 34.321 10.951  79.779 1.000 26.644 0 189 ASP A N   1 ? 
ATOM   1449 C  CA  . ASP A 1 189 ? 32.969 10.674  79.313 1.000 25.496 0 189 ASP A CA  1 ? 
ATOM   1450 C  C   . ASP A 1 189 ? 32.948 10.653  77.779 1.000 26.517 0 189 ASP A C   1 ? 
ATOM   1451 O  O   . ASP A 1 189 ? 32.668 11.685  77.172 1.000 23.560 0 189 ASP A O   1 ? 
ATOM   1452 C  CB  . ASP A 1 189 ? 31.948 11.657  79.863 1.000 26.298 0 189 ASP A CB  1 ? 
ATOM   1453 C  CG  . ASP A 1 189 ? 30.508 11.297  79.498 1.000 26.859 0 189 ASP A CG  1 ? 
ATOM   1454 O  OD1 . ASP A 1 189 ? 30.318 10.462  78.606 1.000 27.701 0 189 ASP A OD1 1 ? 
ATOM   1455 O  OD2 . ASP A 1 189 ? 29.610 11.775  80.144 1.000 30.422 0 189 ASP A OD2 1 ? 
ATOM   1456 N  N   . GLU A 1 190 ? 33.147 9.464   77.187 1.000 24.043 0 190 GLU A N   1 ? 
ATOM   1457 C  CA  . GLU A 1 190 ? 33.335 9.355   75.742 1.000 22.242 0 190 GLU A CA  1 ? 
ATOM   1458 C  C   . GLU A 1 190 ? 32.000 9.585   75.053 1.000 21.909 0 190 GLU A C   1 ? 
ATOM   1459 O  O   . GLU A 1 190 ? 31.952 9.957   73.879 1.000 23.157 0 190 GLU A O   1 ? 
ATOM   1460 C  CB  . GLU A 1 190 ? 33.978 8.013   75.384 1.000 25.160 0 190 GLU A CB  1 ? 
ATOM   1461 C  CG  . GLU A 1 190 ? 35.423 7.894   75.866 1.000 27.441 0 190 GLU A CG  1 ? 
ATOM   1462 C  CD  . GLU A 1 190 ? 36.088 6.586   75.501 1.000 30.439 0 190 GLU A CD  1 ? 
ATOM   1463 O  OE1 . GLU A 1 190 ? 35.330 5.632   75.248 1.000 32.411 0 190 GLU A OE1 1 ? 
ATOM   1464 O  OE2 . GLU A 1 190 ? 37.337 6.543   75.394 1.000 34.914 0 190 GLU A OE2 1 ? 
ATOM   1465 N  N   . VAL A 1 191 ? 30.905 9.318   75.749 1.000 18.997 0 191 VAL A N   1 ? 
ATOM   1466 C  CA  . VAL A 1 191 ? 29.589 9.522   75.169 1.000 21.364 0 191 VAL A CA  1 ? 
ATOM   1467 C  C   . VAL A 1 191 ? 29.353 10.996  74.873 1.000 20.859 0 191 VAL A C   1 ? 
ATOM   1468 O  O   . VAL A 1 191 ? 28.740 11.340  73.874 1.000 21.361 0 191 VAL A O   1 ? 
ATOM   1469 C  CB  . VAL A 1 191 ? 28.457 8.932   76.045 1.000 21.906 0 191 VAL A CB  1 ? 
ATOM   1470 C  CG1 . VAL A 1 191 ? 27.070 9.301   75.507 1.000 24.403 0 191 VAL A CG1 1 ? 
ATOM   1471 C  CG2 . VAL A 1 191 ? 28.625 7.429   76.120 1.000 24.605 0 191 VAL A CG2 1 ? 
ATOM   1472 N  N   . LYS A 1 192 ? 29.807 11.883  75.741 1.000 21.521 0 192 LYS A N   1 ? 
ATOM   1473 C  CA  . LYS A 1 192 ? 29.623 13.297  75.498 1.000 23.963 0 192 LYS A CA  1 ? 
ATOM   1474 C  C   . LYS A 1 192 ? 30.408 13.711  74.251 1.000 23.857 0 192 LYS A C   1 ? 
ATOM   1475 O  O   . LYS A 1 192 ? 29.870 14.453  73.417 1.000 22.068 0 192 LYS A O   1 ? 
ATOM   1476 C  CB  . LYS A 1 192 ? 30.005 14.140  76.726 1.000 29.238 0 192 LYS A CB  1 ? 
ATOM   1477 C  CG  . LYS A 1 192 ? 29.329 15.530  76.726 1.000 36.291 0 192 LYS A CG  1 ? 
ATOM   1478 C  CD  . LYS A 1 192 ? 27.803 15.480  76.650 1.000 41.926 0 192 LYS A CD  1 ? 
ATOM   1479 C  CE  . LYS A 1 192 ? 27.071 16.797  76.635 1.000 45.758 0 192 LYS A CE  1 ? 
ATOM   1480 N  NZ  . LYS A 1 192 ? 25.851 16.710  75.817 1.000 47.630 0 192 LYS A NZ  1 ? 
ATOM   1481 N  N   . PHE A 1 193 ? 31.660 13.249  74.121 1.000 23.531 0 193 PHE A N   1 ? 
ATOM   1482 C  CA  . PHE A 1 193 ? 32.448 13.571  72.943 1.000 21.895 0 193 PHE A CA  1 ? 
ATOM   1483 C  C   . PHE A 1 193 ? 31.704 13.109  71.702 1.000 20.997 0 193 PHE A C   1 ? 
ATOM   1484 O  O   . PHE A 1 193 ? 31.549 13.808  70.713 1.000 21.037 0 193 PHE A O   1 ? 
ATOM   1485 C  CB  . PHE A 1 193 ? 33.832 12.927  72.969 1.000 24.524 0 193 PHE A CB  1 ? 
ATOM   1486 C  CG  . PHE A 1 193 ? 34.840 13.820  73.637 1.000 24.546 0 193 PHE A CG  1 ? 
ATOM   1487 C  CD1 . PHE A 1 193 ? 35.524 14.768  72.906 1.000 25.557 0 193 PHE A CD1 1 ? 
ATOM   1488 C  CD2 . PHE A 1 193 ? 35.050 13.750  75.012 1.000 29.121 0 193 PHE A CD2 1 ? 
ATOM   1489 C  CE1 . PHE A 1 193 ? 36.383 15.644  73.528 1.000 26.635 0 193 PHE A CE1 1 ? 
ATOM   1490 C  CE2 . PHE A 1 193 ? 35.977 14.576  75.611 1.000 28.738 0 193 PHE A CE2 1 ? 
ATOM   1491 C  CZ  . PHE A 1 193 ? 36.635 15.519  74.864 1.000 28.712 0 193 PHE A CZ  1 ? 
ATOM   1492 N  N   . LEU A 1 194 ? 31.345 11.843  71.700 1.000 20.441 0 194 LEU A N   1 ? 
ATOM   1493 C  CA  . LEU A 1 194 ? 30.842 11.329  70.455 1.000 21.501 0 194 LEU A CA  1 ? 
ATOM   1494 C  C   . LEU A 1 194 ? 29.468 11.913  70.141 1.000 20.665 0 194 LEU A C   1 ? 
ATOM   1495 O  O   . LEU A 1 194 ? 29.154 12.162  68.979 1.000 20.780 0 194 LEU A O   1 ? 
ATOM   1496 C  CB  . LEU A 1 194 ? 30.968 9.823   70.494 1.000 24.212 0 194 LEU A CB  1 ? 
ATOM   1497 C  CG  . LEU A 1 194 ? 29.860 9.083   71.214 1.000 22.344 0 194 LEU A CG  1 ? 
ATOM   1498 C  CD1 . LEU A 1 194 ? 28.665 8.920   70.293 1.000 24.099 0 194 LEU A CD1 1 ? 
ATOM   1499 C  CD2 . LEU A 1 194 ? 30.411 7.702   71.548 1.000 26.625 0 194 LEU A CD2 1 ? 
ATOM   1500 N  N   . THR A 1 195 ? 28.660 12.282  71.150 1.000 18.985 0 195 THR A N   1 ? 
ATOM   1501 C  CA  . THR A 1 195 ? 27.359 12.844  70.863 1.000 18.986 0 195 THR A CA  1 ? 
ATOM   1502 C  C   . THR A 1 195 ? 27.519 14.246  70.260 1.000 19.397 0 195 THR A C   1 ? 
ATOM   1503 O  O   . THR A 1 195 ? 26.907 14.594  69.245 1.000 19.242 0 195 THR A O   1 ? 
ATOM   1504 C  CB  . THR A 1 195 ? 26.509 12.864  72.143 1.000 24.559 0 195 THR A CB  1 ? 
ATOM   1505 O  OG1 . THR A 1 195 ? 26.251 11.483  72.378 1.000 29.654 0 195 THR A OG1 1 ? 
ATOM   1506 C  CG2 . THR A 1 195 ? 25.230 13.650  71.952 1.000 31.301 0 195 THR A CG2 1 ? 
ATOM   1507 N  N   . VAL A 1 196 ? 28.366 15.078  70.850 1.000 18.295 0 196 VAL A N   1 ? 
ATOM   1508 C  CA  . VAL A 1 196 ? 28.526 16.414  70.321 1.000 16.778 0 196 VAL A CA  1 ? 
ATOM   1509 C  C   . VAL A 1 196 ? 29.122 16.349  68.913 1.000 16.708 0 196 VAL A C   1 ? 
ATOM   1510 O  O   . VAL A 1 196 ? 28.570 16.951  67.984 1.000 17.696 0 196 VAL A O   1 ? 
ATOM   1511 C  CB  . VAL A 1 196 ? 29.418 17.221  71.275 1.000 19.091 0 196 VAL A CB  1 ? 
ATOM   1512 C  CG1 . VAL A 1 196 ? 29.826 18.558  70.693 1.000 21.368 0 196 VAL A CG1 1 ? 
ATOM   1513 C  CG2 . VAL A 1 196 ? 28.680 17.411  72.606 1.000 19.927 0 196 VAL A CG2 1 ? 
ATOM   1514 N  N   . LEU A 1 197 ? 30.153 15.538  68.729 1.000 17.101 0 197 LEU A N   1 ? 
ATOM   1515 C  CA  . LEU A 1 197 ? 30.926 15.547  67.480 1.000 16.228 0 197 LEU A CA  1 ? 
ATOM   1516 C  C   . LEU A 1 197 ? 30.115 14.886  66.346 1.000 18.016 0 197 LEU A C   1 ? 
ATOM   1517 O  O   . LEU A 1 197 ? 30.352 15.177  65.166 1.000 17.457 0 197 LEU A O   1 ? 
ATOM   1518 C  CB  . LEU A 1 197 ? 32.303 14.921  67.686 1.000 19.126 0 197 LEU A CB  1 ? 
ATOM   1519 C  CG  . LEU A 1 197 ? 33.303 15.779  68.478 1.000 21.094 0 197 LEU A CG  1 ? 
ATOM   1520 C  CD1 . LEU A 1 197 ? 34.597 15.009  68.688 1.000 22.554 0 197 LEU A CD1 1 ? 
ATOM   1521 C  CD2 . LEU A 1 197 ? 33.619 17.091  67.802 1.000 26.102 0 197 LEU A CD2 1 ? 
ATOM   1522 N  N   . CYS A 1 198 ? 29.197 13.986  66.683 1.000 16.856 0 198 CYS A N   1 ? 
ATOM   1523 C  CA  . CYS A 1 198 ? 28.369 13.314  65.695 1.000 19.350 0 198 CYS A CA  1 ? 
ATOM   1524 C  C   . CYS A 1 198 ? 27.030 13.982  65.437 1.000 21.852 0 198 CYS A C   1 ? 
ATOM   1525 O  O   . CYS A 1 198 ? 26.384 13.661  64.438 1.000 19.255 0 198 CYS A O   1 ? 
ATOM   1526 C  CB  . CYS A 1 198 ? 28.088 11.871  66.105 1.000 21.485 0 198 CYS A CB  1 ? 
ATOM   1527 S  SG  . CYS A 1 198 ? 29.550 10.809  65.966 1.000 22.024 0 198 CYS A SG  1 ? 
ATOM   1528 N  N   . SER A 1 199 ? 26.548 14.866  66.328 1.000 17.849 0 199 SER A N   1 ? 
ATOM   1529 C  CA  . SER A 1 199 ? 25.194 15.373  66.145 1.000 18.848 0 199 SER A CA  1 ? 
ATOM   1530 C  C   . SER A 1 199 ? 25.124 16.792  65.620 1.000 18.351 0 199 SER A C   1 ? 
ATOM   1531 O  O   . SER A 1 199 ? 24.115 17.148  65.013 1.000 21.080 0 199 SER A O   1 ? 
ATOM   1532 C  CB  . SER A 1 199 ? 24.375 15.304  67.416 1.000 22.602 0 199 SER A CB  1 ? 
ATOM   1533 O  OG  . SER A 1 199 ? 24.399 13.969  67.888 1.000 26.180 0 199 SER A OG  1 ? 
ATOM   1534 N  N   . ARG A 1 200 ? 26.063 17.637  66.048 1.000 17.482 0 200 ARG A N   1 ? 
ATOM   1535 C  CA  . ARG A 1 200 ? 25.964 19.059  65.807 1.000 18.439 0 200 ARG A CA  1 ? 
ATOM   1536 C  C   . ARG A 1 200 ? 26.344 19.410  64.357 1.000 18.168 0 200 ARG A C   1 ? 
ATOM   1537 O  O   . ARG A 1 200 ? 27.146 18.722  63.733 1.000 18.892 0 200 ARG A O   1 ? 
ATOM   1538 C  CB  . ARG A 1 200 ? 26.814 19.882  66.787 1.000 18.550 0 200 ARG A CB  1 ? 
ATOM   1539 C  CG  . ARG A 1 200 ? 26.547 19.679  68.276 1.000 19.679 0 200 ARG A CG  1 ? 
ATOM   1540 C  CD  . ARG A 1 200 ? 25.152 19.978  68.697 1.000 20.632 0 200 ARG A CD  1 ? 
ATOM   1541 N  NE  . ARG A 1 200 ? 25.112 19.946  70.166 1.000 19.408 0 200 ARG A NE  1 ? 
ATOM   1542 C  CZ  . ARG A 1 200 ? 24.408 19.154  70.908 1.000 25.995 0 200 ARG A CZ  1 ? 
ATOM   1543 N  NH1 . ARG A 1 200 ? 23.674 18.215  70.347 1.000 29.116 0 200 ARG A NH1 1 ? 
ATOM   1544 N  NH2 . ARG A 1 200 ? 24.607 19.226  72.224 1.000 27.452 0 200 ARG A NH2 1 ? 
ATOM   1545 N  N   . ASN A 1 201 ? 25.790 20.526  63.888 1.000 18.807 0 201 ASN A N   1 ? 
ATOM   1546 C  CA  . ASN A 1 201 ? 26.089 21.043  62.573 1.000 19.288 0 201 ASN A CA  1 ? 
ATOM   1547 C  C   . ASN A 1 201 ? 27.501 21.623  62.545 1.000 16.929 0 201 ASN A C   1 ? 
ATOM   1548 O  O   . ASN A 1 201 ? 28.143 21.902  63.568 1.000 16.474 0 201 ASN A O   1 ? 
ATOM   1549 C  CB  . ASN A 1 201 ? 24.995 21.964  62.046 1.000 18.201 0 201 ASN A CB  1 ? 
ATOM   1550 C  CG  . ASN A 1 201 ? 25.031 23.379  62.575 1.000 17.065 0 201 ASN A CG  1 ? 
ATOM   1551 O  OD1 . ASN A 1 201 ? 26.083 24.026  62.575 1.000 20.883 0 201 ASN A OD1 1 ? 
ATOM   1552 N  ND2 . ASN A 1 201 ? 23.879 23.887  62.991 1.000 18.895 0 201 ASN A ND2 1 ? 
ATOM   1553 N  N   . ARG A 1 202 ? 28.066 21.793  61.342 1.000 18.009 0 202 ARG A N   1 ? 
ATOM   1554 C  CA  . ARG A 1 202 ? 29.468 22.194  61.218 1.000 18.181 0 202 ARG A CA  1 ? 
ATOM   1555 C  C   . ARG A 1 202 ? 29.760 23.575  61.788 1.000 17.395 0 202 ARG A C   1 ? 
ATOM   1556 O  O   . ARG A 1 202 ? 30.731 23.759  62.482 1.000 17.626 0 202 ARG A O   1 ? 
ATOM   1557 C  CB  . ARG A 1 202 ? 29.863 22.176  59.726 1.000 22.170 0 202 ARG A CB  1 ? 
ATOM   1558 C  CG  . ARG A 1 202 ? 31.253 22.712  59.440 1.000 23.941 0 202 ARG A CG  1 ? 
ATOM   1559 C  CD  . ARG A 1 202 ? 31.666 22.500  57.994 1.000 27.643 0 202 ARG A CD  1 ? 
ATOM   1560 N  NE  . ARG A 1 202 ? 33.069 22.906  57.897 1.000 29.356 0 202 ARG A NE  1 ? 
ATOM   1561 C  CZ  . ARG A 1 202 ? 33.671 23.674  56.982 1.000 38.451 0 202 ARG A CZ  1 ? 
ATOM   1562 N  NH1 . ARG A 1 202 ? 33.022 24.092  55.919 1.000 46.135 0 202 ARG A NH1 1 ? 
ATOM   1563 N  NH2 . ARG A 1 202 ? 34.955 23.964  57.103 1.000 34.020 0 202 ARG A NH2 1 ? 
ATOM   1564 N  N   . ASN A 1 203 ? 28.938 24.562  61.438 1.000 18.767 0 203 ASN A N   1 ? 
ATOM   1565 C  CA  . ASN A 1 203 ? 29.120 25.897  61.951 1.000 17.608 0 203 ASN A CA  1 ? 
ATOM   1566 C  C   . ASN A 1 203 ? 29.138 25.793  63.485 1.000 18.379 0 203 ASN A C   1 ? 
ATOM   1567 O  O   . ASN A 1 203 ? 29.958 26.399  64.161 1.000 16.171 0 203 ASN A O   1 ? 
ATOM   1568 C  CB  . ASN A 1 203 ? 28.044 26.797  61.362 1.000 19.715 0 203 ASN A CB  1 ? 
ATOM   1569 C  CG  . ASN A 1 203 ? 28.242 28.256  61.704 1.000 22.429 0 203 ASN A CG  1 ? 
ATOM   1570 O  OD1 . ASN A 1 203 ? 29.396 28.689  61.820 1.000 24.268 0 203 ASN A OD1 1 ? 
ATOM   1571 N  ND2 . ASN A 1 203 ? 27.161 28.995  61.893 1.000 23.838 0 203 ASN A ND2 1 ? 
ATOM   1572 N  N   . HIS A 1 204 ? 28.175 25.079  64.028 1.000 16.922 0 204 HIS A N   1 ? 
ATOM   1573 C  CA  . HIS A 1 204 ? 28.130 24.950  65.485 1.000 16.715 0 204 HIS A CA  1 ? 
ATOM   1574 C  C   . HIS A 1 204 ? 29.415 24.347  66.044 1.000 15.352 0 204 HIS A C   1 ? 
ATOM   1575 O  O   . HIS A 1 204 ? 30.051 24.849  66.963 1.000 16.995 0 204 HIS A O   1 ? 
ATOM   1576 C  CB  . HIS A 1 204 ? 26.958 24.028  65.807 1.000 15.070 0 204 HIS A CB  1 ? 
ATOM   1577 C  CG  . HIS A 1 204 ? 26.726 23.933  67.272 1.000 17.664 0 204 HIS A CG  1 ? 
ATOM   1578 N  ND1 . HIS A 1 204 ? 27.407 23.102  68.147 1.000 19.504 0 204 HIS A ND1 1 ? 
ATOM   1579 C  CD2 . HIS A 1 204 ? 25.797 24.592  67.994 1.000 16.560 0 204 HIS A CD2 1 ? 
ATOM   1580 C  CE1 . HIS A 1 204 ? 26.918 23.326  69.384 1.000 16.986 0 204 HIS A CE1 1 ? 
ATOM   1581 N  NE2 . HIS A 1 204 ? 25.953 24.189  69.307 1.000 21.263 0 204 HIS A NE2 1 ? 
ATOM   1582 N  N   . LEU A 1 205 ? 29.920 23.258  65.436 1.000 15.754 0 205 LEU A N   1 ? 
ATOM   1583 C  CA  . LEU A 1 205 ? 31.135 22.617  65.924 1.000 16.354 0 205 LEU A CA  1 ? 
ATOM   1584 C  C   . LEU A 1 205 ? 32.354 23.512  65.820 1.000 15.571 0 205 LEU A C   1 ? 
ATOM   1585 O  O   . LEU A 1 205 ? 33.177 23.505  66.726 1.000 18.322 0 205 LEU A O   1 ? 
ATOM   1586 C  CB  . LEU A 1 205 ? 31.347 21.302  65.186 1.000 17.794 0 205 LEU A CB  1 ? 
ATOM   1587 C  CG  . LEU A 1 205 ? 30.461 20.142  65.625 1.000 19.525 0 205 LEU A CG  1 ? 
ATOM   1588 C  CD1 . LEU A 1 205 ? 30.757 18.902  64.799 1.000 19.803 0 205 LEU A CD1 1 ? 
ATOM   1589 C  CD2 . LEU A 1 205 ? 30.695 19.794  67.107 1.000 22.063 0 205 LEU A CD2 1 ? 
ATOM   1590 N  N   . LEU A 1 206 ? 32.493 24.262  64.712 1.000 18.690 0 206 LEU A N   1 ? 
ATOM   1591 C  CA  . LEU A 1 206 ? 33.601 25.195  64.572 1.000 20.646 0 206 LEU A CA  1 ? 
ATOM   1592 C  C   . LEU A 1 206 ? 33.590 26.214  65.701 1.000 19.144 0 206 LEU A C   1 ? 
ATOM   1593 O  O   . LEU A 1 206 ? 34.637 26.462  66.277 1.000 19.470 0 206 LEU A O   1 ? 
ATOM   1594 C  CB  . LEU A 1 206 ? 33.537 25.836  63.191 1.000 22.531 0 206 LEU A CB  1 ? 
ATOM   1595 C  CG  . LEU A 1 206 ? 33.839 24.869  62.046 1.000 23.185 0 206 LEU A CG  1 ? 
ATOM   1596 C  CD1 . LEU A 1 206 ? 33.694 25.687  60.747 1.000 25.750 0 206 LEU A CD1 1 ? 
ATOM   1597 C  CD2 . LEU A 1 206 ? 35.195 24.241  62.142 1.000 22.611 0 206 LEU A CD2 1 ? 
ATOM   1598 N  N   . HIS A 1 207 ? 32.386 26.656  66.108 1.000 17.639 0 207 HIS A N   1 ? 
ATOM   1599 C  CA  . HIS A 1 207 ? 32.255 27.542  67.269 1.000 18.334 0 207 HIS A CA  1 ? 
ATOM   1600 C  C   . HIS A 1 207 ? 32.568 26.823  68.579 1.000 18.516 0 207 HIS A C   1 ? 
ATOM   1601 O  O   . HIS A 1 207 ? 33.215 27.406  69.457 1.000 19.023 0 207 HIS A O   1 ? 
ATOM   1602 C  CB  . HIS A 1 207 ? 30.890 28.210  67.261 1.000 18.851 0 207 HIS A CB  1 ? 
ATOM   1603 C  CG  . HIS A 1 207 ? 30.765 29.261  66.226 1.000 19.456 0 207 HIS A CG  1 ? 
ATOM   1604 N  ND1 . HIS A 1 207 ? 30.536 28.986  64.894 1.000 22.346 0 207 HIS A ND1 1 ? 
ATOM   1605 C  CD2 . HIS A 1 207 ? 30.792 30.619  66.354 1.000 23.422 0 207 HIS A CD2 1 ? 
ATOM   1606 C  CE1 . HIS A 1 207 ? 30.462 30.159  64.233 1.000 22.450 0 207 HIS A CE1 1 ? 
ATOM   1607 N  NE2 . HIS A 1 207 ? 30.614 31.147  65.111 1.000 22.868 0 207 HIS A NE2 1 ? 
ATOM   1608 N  N   . VAL A 1 208 ? 32.211 25.533  68.697 1.000 17.353 0 208 VAL A N   1 ? 
ATOM   1609 C  CA  . VAL A 1 208 ? 32.537 24.786  69.910 1.000 17.635 0 208 VAL A CA  1 ? 
ATOM   1610 C  C   . VAL A 1 208 ? 34.047 24.623  70.041 1.000 19.230 0 208 VAL A C   1 ? 
ATOM   1611 O  O   . VAL A 1 208 ? 34.624 24.758  71.112 1.000 19.315 0 208 VAL A O   1 ? 
ATOM   1612 C  CB  . VAL A 1 208 ? 31.830 23.421  69.923 1.000 15.820 0 208 VAL A CB  1 ? 
ATOM   1613 C  CG1 . VAL A 1 208 ? 32.403 22.529  71.026 1.000 16.705 0 208 VAL A CG1 1 ? 
ATOM   1614 C  CG2 . VAL A 1 208 ? 30.331 23.533  70.020 1.000 15.364 0 208 VAL A CG2 1 ? 
ATOM   1615 N  N   . PHE A 1 209 ? 34.725 24.308  68.947 1.000 18.484 0 209 PHE A N   1 ? 
ATOM   1616 C  CA  . PHE A 1 209 ? 36.169 24.172  68.945 1.000 19.959 0 209 PHE A CA  1 ? 
ATOM   1617 C  C   . PHE A 1 209 ? 36.848 25.445  69.452 1.000 19.111 0 209 PHE A C   1 ? 
ATOM   1618 O  O   . PHE A 1 209 ? 37.743 25.361  70.273 1.000 20.169 0 209 PHE A O   1 ? 
ATOM   1619 C  CB  . PHE A 1 209 ? 36.737 23.803  67.569 1.000 21.021 0 209 PHE A CB  1 ? 
ATOM   1620 C  CG  . PHE A 1 209 ? 36.171 22.538  66.933 1.000 21.158 0 209 PHE A CG  1 ? 
ATOM   1621 C  CD1 . PHE A 1 209 ? 35.525 21.568  67.682 1.000 21.224 0 209 PHE A CD1 1 ? 
ATOM   1622 C  CD2 . PHE A 1 209 ? 36.365 22.316  65.586 1.000 22.321 0 209 PHE A CD2 1 ? 
ATOM   1623 C  CE1 . PHE A 1 209 ? 34.994 20.447  67.064 1.000 21.364 0 209 PHE A CE1 1 ? 
ATOM   1624 C  CE2 . PHE A 1 209 ? 35.853 21.166  64.986 1.000 21.950 0 209 PHE A CE2 1 ? 
ATOM   1625 C  CZ  . PHE A 1 209 ? 35.154 20.266  65.722 1.000 21.693 0 209 PHE A CZ  1 ? 
ATOM   1626 N  N   . ASP A 1 210 ? 36.383 26.612  68.986 1.000 20.232 0 210 ASP A N   1 ? 
ATOM   1627 C  CA  . ASP A 1 210 ? 36.954 27.885  69.389 1.000 22.402 0 210 ASP A CA  1 ? 
ATOM   1628 C  C   . ASP A 1 210 ? 36.652 28.138  70.865 1.000 22.384 0 210 ASP A C   1 ? 
ATOM   1629 O  O   . ASP A 1 210 ? 37.549 28.501  71.645 1.000 23.640 0 210 ASP A O   1 ? 
ATOM   1630 C  CB  . ASP A 1 210 ? 36.381 29.026  68.573 1.000 23.213 0 210 ASP A CB  1 ? 
ATOM   1631 C  CG  . ASP A 1 210 ? 36.822 29.057  67.128 1.000 27.965 0 210 ASP A CG  1 ? 
ATOM   1632 O  OD1 . ASP A 1 210 ? 37.716 28.253  66.762 1.000 33.849 0 210 ASP A OD1 1 ? 
ATOM   1633 O  OD2 . ASP A 1 210 ? 36.187 29.833  66.378 1.000 31.509 0 210 ASP A OD2 1 ? 
ATOM   1634 N  N   . GLU A 1 211 ? 35.407 27.854  71.270 1.000 21.896 0 211 GLU A N   1 ? 
ATOM   1635 C  CA  . GLU A 1 211 ? 35.063 28.049  72.666 1.000 22.545 0 211 GLU A CA  1 ? 
ATOM   1636 C  C   . GLU A 1 211 ? 35.856 27.102  73.552 1.000 20.934 0 211 GLU A C   1 ? 
ATOM   1637 O  O   . GLU A 1 211 ? 36.280 27.475  74.642 1.000 23.749 0 211 GLU A O   1 ? 
ATOM   1638 C  CB  . GLU A 1 211 ? 33.569 27.910  72.894 1.000 22.663 0 211 GLU A CB  1 ? 
ATOM   1639 C  CG  . GLU A 1 211 ? 33.117 28.117  74.330 1.000 22.493 0 211 GLU A CG  1 ? 
ATOM   1640 C  CD  . GLU A 1 211 ? 33.114 29.532  74.873 1.000 30.009 0 211 GLU A CD  1 ? 
ATOM   1641 O  OE1 . GLU A 1 211 ? 33.627 30.451  74.216 1.000 27.919 0 211 GLU A OE1 1 ? 
ATOM   1642 O  OE2 . GLU A 1 211 ? 32.537 29.675  75.972 1.000 29.778 0 211 GLU A OE2 1 ? 
ATOM   1643 N  N   . TYR A 1 212 ? 36.005 25.842  73.136 1.000 21.276 0 212 TYR A N   1 ? 
ATOM   1644 C  CA  . TYR A 1 212 ? 36.753 24.900  73.943 1.000 21.552 0 212 TYR A CA  1 ? 
ATOM   1645 C  C   . TYR A 1 212 ? 38.181 25.379  74.186 1.000 22.420 0 212 TYR A C   1 ? 
ATOM   1646 O  O   . TYR A 1 212 ? 38.696 25.263  75.300 1.000 25.219 0 212 TYR A O   1 ? 
ATOM   1647 C  CB  . TYR A 1 212 ? 36.765 23.536  73.229 1.000 20.531 0 212 TYR A CB  1 ? 
ATOM   1648 C  CG  . TYR A 1 212 ? 37.477 22.482  74.058 1.000 19.197 0 212 TYR A CG  1 ? 
ATOM   1649 C  CD1 . TYR A 1 212 ? 36.804 21.764  75.018 1.000 23.106 0 212 TYR A CD1 1 ? 
ATOM   1650 C  CD2 . TYR A 1 212 ? 38.835 22.232  73.881 1.000 19.723 0 212 TYR A CD2 1 ? 
ATOM   1651 C  CE1 . TYR A 1 212 ? 37.453 20.806  75.789 1.000 20.627 0 212 TYR A CE1 1 ? 
ATOM   1652 C  CE2 . TYR A 1 212 ? 39.497 21.276  74.644 1.000 20.401 0 212 TYR A CE2 1 ? 
ATOM   1653 C  CZ  . TYR A 1 212 ? 38.800 20.571  75.601 1.000 20.773 0 212 TYR A CZ  1 ? 
ATOM   1654 O  OH  . TYR A 1 212 ? 39.368 19.612  76.400 1.000 24.713 0 212 TYR A OH  1 ? 
ATOM   1655 N  N   . LYS A 1 213 ? 38.830 25.943  73.172 1.000 23.583 0 213 LYS A N   1 ? 
ATOM   1656 C  CA  . LYS A 1 213 ? 40.177 26.480  73.334 1.000 27.154 0 213 LYS A CA  1 ? 
ATOM   1657 C  C   . LYS A 1 213 ? 40.158 27.656  74.321 1.000 27.502 0 213 LYS A C   1 ? 
ATOM   1658 O  O   . LYS A 1 213 ? 41.037 27.720  75.176 1.000 28.633 0 213 LYS A O   1 ? 
ATOM   1659 C  CB  . LYS A 1 213 ? 40.716 26.887  71.959 1.000 30.197 0 213 LYS A CB  1 ? 
ATOM   1660 C  CG  . LYS A 1 213 ? 42.095 27.542  71.931 1.000 33.244 0 213 LYS A CG  1 ? 
ATOM   1661 C  CD  . LYS A 1 213 ? 43.217 26.628  72.399 1.000 37.132 0 213 LYS A CD  1 ? 
ATOM   1662 C  CE  . LYS A 1 213 ? 44.583 27.212  72.112 1.000 43.372 0 213 LYS A CE  1 ? 
ATOM   1663 N  NZ  . LYS A 1 213 ? 44.930 27.017  70.698 1.000 48.205 0 213 LYS A NZ  1 ? 
ATOM   1664 N  N   . ARG A 1 214 ? 39.130 28.524  74.211 1.000 29.435 0 214 ARG A N   1 ? 
ATOM   1665 C  CA  . ARG A 1 214 ? 38.979 29.696  75.069 1.000 26.970 0 214 ARG A CA  1 ? 
ATOM   1666 C  C   . ARG A 1 214 ? 38.916 29.259  76.528 1.000 29.924 0 214 ARG A C   1 ? 
ATOM   1667 O  O   . ARG A 1 214 ? 39.622 29.813  77.362 1.000 30.201 0 214 ARG A O   1 ? 
ATOM   1668 C  CB  . ARG A 1 214 ? 37.810 30.593  74.654 1.000 29.763 0 214 ARG A CB  1 ? 
ATOM   1669 C  CG  . ARG A 1 214 ? 37.792 31.906  75.432 1.000 33.200 0 214 ARG A CG  1 ? 
ATOM   1670 C  CD  . ARG A 1 214 ? 36.498 32.671  75.271 1.000 34.325 0 214 ARG A CD  1 ? 
ATOM   1671 N  NE  . ARG A 1 214 ? 35.322 32.110  75.953 1.000 36.397 0 214 ARG A NE  1 ? 
ATOM   1672 C  CZ  . ARG A 1 214 ? 35.086 32.017  77.262 1.000 37.791 0 214 ARG A CZ  1 ? 
ATOM   1673 N  NH1 . ARG A 1 214 ? 35.999 32.425  78.141 1.000 44.028 0 214 ARG A NH1 1 ? 
ATOM   1674 N  NH2 . ARG A 1 214 ? 33.933 31.525  77.708 1.000 34.120 0 214 ARG A NH2 1 ? 
ATOM   1675 N  N   . ILE A 1 215 ? 38.177 28.196  76.854 1.000 29.603 0 215 ILE A N   1 ? 
ATOM   1676 C  CA  . ILE A 1 215 ? 37.966 27.860  78.247 1.000 28.318 0 215 ILE A CA  1 ? 
ATOM   1677 C  C   . ILE A 1 215 ? 39.067 26.940  78.791 1.000 28.385 0 215 ILE A C   1 ? 
ATOM   1678 O  O   . ILE A 1 215 ? 39.288 26.881  80.005 1.000 32.964 0 215 ILE A O   1 ? 
ATOM   1679 C  CB  . ILE A 1 215 ? 36.527 27.355  78.488 1.000 27.937 0 215 ILE A CB  1 ? 
ATOM   1680 C  CG1 . ILE A 1 215 ? 36.228 26.008  77.822 1.000 26.108 0 215 ILE A CG1 1 ? 
ATOM   1681 C  CG2 . ILE A 1 215 ? 35.501 28.407  78.063 1.000 30.527 0 215 ILE A CG2 1 ? 
ATOM   1682 C  CD1 . ILE A 1 215 ? 34.854 25.460  78.143 1.000 28.080 0 215 ILE A CD1 1 ? 
ATOM   1683 N  N   . SER A 1 216 ? 39.753 26.206  77.928 1.000 28.186 0 216 SER A N   1 ? 
ATOM   1684 C  CA  . SER A 1 216 ? 40.619 25.126  78.374 1.000 28.995 0 216 SER A CA  1 ? 
ATOM   1685 C  C   . SER A 1 216 ? 42.089 25.437  78.074 1.000 30.713 0 216 SER A C   1 ? 
ATOM   1686 O  O   . SER A 1 216 ? 42.970 24.765  78.575 1.000 33.590 0 216 SER A O   1 ? 
ATOM   1687 C  CB  . SER A 1 216 ? 40.231 23.835  77.707 1.000 30.515 0 216 SER A CB  1 ? 
ATOM   1688 O  OG  . SER A 1 216 ? 40.714 23.801  76.369 1.000 28.265 0 216 SER A OG  1 ? 
ATOM   1689 N  N   . GLN A 1 217 ? 42.337 26.410  77.204 1.000 30.678 0 217 GLN A N   1 ? 
ATOM   1690 C  CA  . GLN A 1 217 ? 43.653 26.723  76.660 1.000 31.706 0 217 GLN A CA  1 ? 
ATOM   1691 C  C   . GLN A 1 217 ? 44.234 25.567  75.856 1.000 33.114 0 217 GLN A C   1 ? 
ATOM   1692 O  O   . GLN A 1 217 ? 45.410 25.599  75.512 1.000 32.444 0 217 GLN A O   1 ? 
ATOM   1693 C  CB  . GLN A 1 217 ? 44.721 27.143  77.680 1.000 33.006 0 217 GLN A CB  1 ? 
ATOM   1694 C  CG  . GLN A 1 217 ? 44.365 28.413  78.442 1.000 39.088 0 217 GLN A CG  1 ? 
ATOM   1695 C  CD  . GLN A 1 217 ? 43.429 28.155  79.598 1.000 43.976 0 217 GLN A CD  1 ? 
ATOM   1696 O  OE1 . GLN A 1 217 ? 43.653 27.243  80.400 1.000 55.408 0 217 GLN A OE1 1 ? 
ATOM   1697 N  NE2 . GLN A 1 217 ? 42.364 28.939  79.698 1.000 50.521 0 217 GLN A NE2 1 ? 
ATOM   1698 N  N   . LYS A 1 218 ? 43.410 24.579  75.478 1.000 32.180 0 218 LYS A N   1 ? 
ATOM   1699 C  CA  . LYS A 1 218 ? 43.909 23.460  74.697 1.000 28.852 0 218 LYS A CA  1 ? 
ATOM   1700 C  C   . LYS A 1 218 ? 43.031 23.307  73.465 1.000 24.749 0 218 LYS A C   1 ? 
ATOM   1701 O  O   . LYS A 1 218 ? 41.826 23.567  73.506 1.000 26.605 0 218 LYS A O   1 ? 
ATOM   1702 C  CB  . LYS A 1 218 ? 43.894 22.152  75.490 1.000 33.262 0 218 LYS A CB  1 ? 
ATOM   1703 C  CG  . LYS A 1 218 ? 45.141 21.913  76.364 1.000 38.284 0 218 LYS A CG  1 ? 
ATOM   1704 C  CD  . LYS A 1 218 ? 45.052 20.688  77.262 1.000 43.221 0 218 LYS A CD  1 ? 
ATOM   1705 C  CE  . LYS A 1 218 ? 43.959 20.846  78.278 1.000 50.624 0 218 LYS A CE  1 ? 
ATOM   1706 N  NZ  . LYS A 1 218 ? 44.046 19.893  79.390 1.000 51.557 0 218 LYS A NZ  1 ? 
ATOM   1707 N  N   . ASP A 1 219 ? 43.656 22.952  72.352 1.000 24.407 0 219 ASP A N   1 ? 
ATOM   1708 C  CA  . ASP A 1 219 ? 42.862 22.581  71.197 1.000 26.399 0 219 ASP A CA  1 ? 
ATOM   1709 C  C   . ASP A 1 219 ? 42.126 21.279  71.475 1.000 25.120 0 219 ASP A C   1 ? 
ATOM   1710 O  O   . ASP A 1 219 ? 42.633 20.379  72.134 1.000 23.536 0 219 ASP A O   1 ? 
ATOM   1711 C  CB  . ASP A 1 219 ? 43.715 22.571  69.945 1.000 30.525 0 219 ASP A CB  1 ? 
ATOM   1712 C  CG  . ASP A 1 219 ? 43.845 23.972  69.372 1.000 41.319 0 219 ASP A CG  1 ? 
ATOM   1713 O  OD1 . ASP A 1 219 ? 42.784 24.561  69.032 1.000 50.048 0 219 ASP A OD1 1 ? 
ATOM   1714 O  OD2 . ASP A 1 219 ? 44.976 24.481  69.352 1.000 52.175 0 219 ASP A OD2 1 ? 
ATOM   1715 N  N   . ILE A 1 220 ? 40.933 21.160  70.895 1.000 23.505 0 220 ILE A N   1 ? 
ATOM   1716 C  CA  . ILE A 1 220 ? 40.132 19.968  71.121 1.000 23.876 0 220 ILE A CA  1 ? 
ATOM   1717 C  C   . ILE A 1 220 ? 40.898 18.743  70.625 1.000 19.534 0 220 ILE A C   1 ? 
ATOM   1718 O  O   . ILE A 1 220 ? 40.769 17.673  71.209 1.000 21.119 0 220 ILE A O   1 ? 
ATOM   1719 C  CB  . ILE A 1 220 ? 38.744 20.076  70.477 1.000 22.860 0 220 ILE A CB  1 ? 
ATOM   1720 C  CG1 . ILE A 1 220 ? 37.846 18.975  71.005 1.000 25.474 0 220 ILE A CG1 1 ? 
ATOM   1721 C  CG2 . ILE A 1 220 ? 38.862 20.072  68.951 1.000 25.352 0 220 ILE A CG2 1 ? 
ATOM   1722 C  CD1 . ILE A 1 220 ? 36.377 19.105  70.628 1.000 27.126 0 220 ILE A CD1 1 ? 
ATOM   1723 N  N   . GLU A 1 221 ? 41.730 18.873  69.585 1.000 20.875 0 221 GLU A N   1 ? 
ATOM   1724 C  CA  . GLU A 1 221 ? 42.500 17.713  69.141 1.000 23.508 0 221 GLU A CA  1 ? 
ATOM   1725 C  C   . GLU A 1 221 ? 43.475 17.241  70.217 1.000 24.083 0 221 GLU A C   1 ? 
ATOM   1726 O  O   . GLU A 1 221 ? 43.710 16.055  70.400 1.000 24.542 0 221 GLU A O   1 ? 
ATOM   1727 C  CB  . GLU A 1 221 ? 43.308 17.922  67.855 1.000 26.066 0 221 GLU A CB  1 ? 
ATOM   1728 C  CG  . GLU A 1 221 ? 42.419 18.169  66.646 1.000 29.399 0 221 GLU A CG  1 ? 
ATOM   1729 C  CD  . GLU A 1 221 ? 42.099 19.625  66.415 1.000 34.684 0 221 GLU A CD  1 ? 
ATOM   1730 O  OE1 . GLU A 1 221 ? 41.985 20.363  67.433 1.000 38.123 0 221 GLU A OE1 1 ? 
ATOM   1731 O  OE2 . GLU A 1 221 ? 41.985 19.992  65.216 1.000 40.561 0 221 GLU A OE2 1 ? 
ATOM   1732 N  N   . GLN A 1 222 ? 44.053 18.175  70.963 1.000 26.696 0 222 GLN A N   1 ? 
ATOM   1733 C  CA  . GLN A 1 222 ? 45.008 17.778  71.977 1.000 29.769 0 222 GLN A CA  1 ? 
ATOM   1734 C  C   . GLN A 1 222 ? 44.301 16.952  73.044 1.000 26.300 0 222 GLN A C   1 ? 
ATOM   1735 O  O   . GLN A 1 222 ? 44.817 15.926  73.517 1.000 26.121 0 222 GLN A O   1 ? 
ATOM   1736 C  CB  . GLN A 1 222 ? 45.662 19.017  72.604 1.000 28.470 0 222 GLN A CB  1 ? 
ATOM   1737 C  CG  . GLN A 1 222 ? 46.441 19.889  71.626 1.000 34.008 0 222 GLN A CG  1 ? 
ATOM   1738 C  CD  . GLN A 1 222 ? 47.019 21.092  72.343 1.000 35.900 0 222 GLN A CD  1 ? 
ATOM   1739 O  OE1 . GLN A 1 222 ? 46.422 22.170  72.399 1.000 31.750 0 222 GLN A OE1 1 ? 
ATOM   1740 N  NE2 . GLN A 1 222 ? 48.122 20.868  73.032 1.000 42.606 0 222 GLN A NE2 1 ? 
ATOM   1741 N  N   . SER A 1 223 ? 43.111 17.409  73.437 1.000 23.712 0 223 SER A N   1 ? 
ATOM   1742 C  CA  . SER A 1 223 ? 42.335 16.715  74.457 1.000 23.693 0 223 SER A CA  1 ? 
ATOM   1743 C  C   . SER A 1 223 ? 41.862 15.341  73.980 1.000 23.115 0 223 SER A C   1 ? 
ATOM   1744 O  O   . SER A 1 223 ? 41.959 14.367  74.704 1.000 24.836 0 223 SER A O   1 ? 
ATOM   1745 C  CB  . SER A 1 223 ? 41.189 17.569  74.920 1.000 25.677 0 223 SER A CB  1 ? 
ATOM   1746 O  OG  . SER A 1 223 ? 41.714 18.707  75.585 1.000 28.939 0 223 SER A OG  1 ? 
ATOM   1747 N  N   . ILE A 1 224 ? 41.377 15.244  72.727 1.000 22.687 0 224 ILE A N   1 ? 
ATOM   1748 C  CA  . ILE A 1 224 ? 41.041 13.951  72.141 1.000 23.679 0 224 ILE A CA  1 ? 
ATOM   1749 C  C   . ILE A 1 224 ? 42.227 12.984  72.229 1.000 23.471 0 224 ILE A C   1 ? 
ATOM   1750 O  O   . ILE A 1 224 ? 42.070 11.815  72.575 1.000 23.192 0 224 ILE A O   1 ? 
ATOM   1751 C  CB  . ILE A 1 224 ? 40.504 14.106  70.692 1.000 20.995 0 224 ILE A CB  1 ? 
ATOM   1752 C  CG1 . ILE A 1 224 ? 39.148 14.798  70.710 1.000 21.519 0 224 ILE A CG1 1 ? 
ATOM   1753 C  CG2 . ILE A 1 224 ? 40.432 12.767  69.949 1.000 23.005 0 224 ILE A CG2 1 ? 
ATOM   1754 C  CD1 . ILE A 1 224 ? 38.716 15.376  69.377 1.000 21.871 0 224 ILE A CD1 1 ? 
ATOM   1755 N  N   . LYS A 1 225 ? 43.415 13.446  71.831 1.000 24.001 0 225 LYS A N   1 ? 
ATOM   1756 C  CA  . LYS A 1 225 ? 44.605 12.600  71.856 1.000 24.188 0 225 LYS A CA  1 ? 
ATOM   1757 C  C   . LYS A 1 225 ? 44.986 12.145  73.261 1.000 26.964 0 225 LYS A C   1 ? 
ATOM   1758 O  O   . LYS A 1 225 ? 45.365 10.995  73.456 1.000 29.040 0 225 LYS A O   1 ? 
ATOM   1759 C  CB  . LYS A 1 225 ? 45.740 13.371  71.177 1.000 29.623 0 225 LYS A CB  1 ? 
ATOM   1760 C  CG  . LYS A 1 225 ? 45.622 13.449  69.671 1.000 32.620 0 225 LYS A CG  1 ? 
ATOM   1761 C  CD  . LYS A 1 225 ? 46.742 14.282  69.072 1.000 38.803 0 225 LYS A CD  1 ? 
ATOM   1762 C  CE  . LYS A 1 225 ? 46.439 14.612  67.650 1.000 43.469 0 225 LYS A CE  1 ? 
ATOM   1763 N  NZ  . LYS A 1 225 ? 47.463 15.453  67.025 1.000 46.708 0 225 LYS A NZ  1 ? 
ATOM   1764 N  N   . SER A 1 226 ? 44.852 13.013  74.266 1.000 26.548 0 226 SER A N   1 ? 
ATOM   1765 C  CA  . SER A 1 226 ? 45.223 12.582  75.616 1.000 28.903 0 226 SER A CA  1 ? 
ATOM   1766 C  C   . SER A 1 226 ? 44.093 11.853  76.352 1.000 31.774 0 226 SER A C   1 ? 
ATOM   1767 O  O   . SER A 1 226 ? 44.379 11.188  77.332 1.000 33.643 0 226 SER A O   1 ? 
ATOM   1768 C  CB  . SER A 1 226 ? 45.715 13.720  76.421 1.000 30.367 0 226 SER A CB  1 ? 
ATOM   1769 O  OG  . SER A 1 226 ? 44.733 14.723  76.572 1.000 34.625 0 226 SER A OG  1 ? 
ATOM   1770 N  N   . GLU A 1 227 ? 42.835 11.924  75.896 1.000 30.749 0 227 GLU A N   1 ? 
ATOM   1771 C  CA  . GLU A 1 227 ? 41.691 11.427  76.667 1.000 27.831 0 227 GLU A CA  1 ? 
ATOM   1772 C  C   . GLU A 1 227 ? 40.985 10.218  76.029 1.000 26.926 0 227 GLU A C   1 ? 
ATOM   1773 O  O   . GLU A 1 227 ? 40.075 9.662   76.637 1.000 30.062 0 227 GLU A O   1 ? 
ATOM   1774 C  CB  . GLU A 1 227 ? 40.660 12.540  76.860 1.000 30.696 0 227 GLU A CB  1 ? 
ATOM   1775 C  CG  . GLU A 1 227 ? 41.186 13.753  77.623 1.000 31.012 0 227 GLU A CG  1 ? 
ATOM   1776 C  CD  . GLU A 1 227 ? 40.335 15.018  77.608 1.000 37.209 0 227 GLU A CD  1 ? 
ATOM   1777 O  OE1 . GLU A 1 227 ? 39.182 15.012  77.163 1.000 35.525 0 227 GLU A OE1 1 ? 
ATOM   1778 O  OE2 . GLU A 1 227 ? 40.846 16.043  78.088 1.000 33.835 0 227 GLU A OE2 1 ? 
ATOM   1779 N  N   . THR A 1 228 ? 41.344 9.856   74.788 1.000 26.954 0 228 THR A N   1 ? 
ATOM   1780 C  CA  . THR A 1 228 ? 40.786 8.704   74.098 1.000 26.465 0 228 THR A CA  1 ? 
ATOM   1781 C  C   . THR A 1 228 ? 41.933 7.976   73.420 1.000 23.837 0 228 THR A C   1 ? 
ATOM   1782 O  O   . THR A 1 228 ? 43.017 8.520   73.342 1.000 25.989 0 228 THR A O   1 ? 
ATOM   1783 C  CB  . THR A 1 228 ? 39.705 9.102   73.081 1.000 27.453 0 228 THR A CB  1 ? 
ATOM   1784 O  OG1 . THR A 1 228 ? 40.289 9.847   72.019 1.000 25.748 0 228 THR A OG1 1 ? 
ATOM   1785 C  CG2 . THR A 1 228 ? 38.589 9.931   73.687 1.000 25.728 0 228 THR A CG2 1 ? 
ATOM   1786 N  N   . SER A 1 229 ? 41.668 6.767   72.896 1.000 27.624 0 229 SER A N   1 ? 
ATOM   1787 C  CA  . SER A 1 229 ? 42.684 5.937   72.263 1.000 27.639 0 229 SER A CA  1 ? 
ATOM   1788 C  C   . SER A 1 229 ? 42.056 5.130   71.130 1.000 25.195 0 229 SER A C   1 ? 
ATOM   1789 O  O   . SER A 1 229 ? 40.842 5.068   71.006 1.000 24.938 0 229 SER A O   1 ? 
ATOM   1790 C  CB  . SER A 1 229 ? 43.322 4.985   73.270 1.000 31.002 0 229 SER A CB  1 ? 
ATOM   1791 O  OG  . SER A 1 229 ? 42.316 4.228   73.924 1.000 37.983 0 229 SER A OG  1 ? 
ATOM   1792 N  N   . GLY A 1 230 ? 42.901 4.493   70.320 1.000 25.595 0 230 GLY A N   1 ? 
ATOM   1793 C  CA  . GLY A 1 230 ? 42.425 3.448   69.427 1.000 27.044 0 230 GLY A CA  1 ? 
ATOM   1794 C  C   . GLY A 1 230 ? 41.643 4.003   68.236 1.000 25.568 0 230 GLY A C   1 ? 
ATOM   1795 O  O   . GLY A 1 230 ? 41.799 5.169   67.846 1.000 24.196 0 230 GLY A O   1 ? 
ATOM   1796 N  N   . SER A 1 231 ? 40.816 3.138   67.638 1.000 24.788 0 231 SER A N   1 ? 
ATOM   1797 C  CA  . SER A 1 231 ? 40.062 3.528   66.454 1.000 25.265 0 231 SER A CA  1 ? 
ATOM   1798 C  C   . SER A 1 231 ? 39.073 4.649   66.791 1.000 23.007 0 231 SER A C   1 ? 
ATOM   1799 O  O   . SER A 1 231 ? 38.744 5.519   65.962 1.000 21.125 0 231 SER A O   1 ? 
ATOM   1800 C  CB  . SER A 1 231 ? 39.313 2.345   65.858 1.000 32.397 0 231 SER A CB  1 ? 
ATOM   1801 O  OG  . SER A 1 231 ? 40.236 1.312   65.537 1.000 44.944 0 231 SER A OG  1 ? 
ATOM   1802 N  N   . PHE A 1 232 ? 38.597 4.629   68.039 1.000 21.792 0 232 PHE A N   1 ? 
ATOM   1803 C  CA  . PHE A 1 232 ? 37.655 5.630   68.489 1.000 21.867 0 232 PHE A CA  1 ? 
ATOM   1804 C  C   . PHE A 1 232 ? 38.313 7.009   68.454 1.000 20.567 0 232 PHE A C   1 ? 
ATOM   1805 O  O   . PHE A 1 232 ? 37.713 7.962   67.948 1.000 18.570 0 232 PHE A O   1 ? 
ATOM   1806 C  CB  . PHE A 1 232 ? 37.132 5.279   69.889 1.000 21.407 0 232 PHE A CB  1 ? 
ATOM   1807 C  CG  . PHE A 1 232 ? 36.231 6.350   70.491 1.000 20.735 0 232 PHE A CG  1 ? 
ATOM   1808 C  CD1 . PHE A 1 232 ? 34.999 6.659   69.943 1.000 19.461 0 232 PHE A CD1 1 ? 
ATOM   1809 C  CD2 . PHE A 1 232 ? 36.579 6.993   71.680 1.000 23.132 0 232 PHE A CD2 1 ? 
ATOM   1810 C  CE1 . PHE A 1 232 ? 34.171 7.609   70.511 1.000 19.388 0 232 PHE A CE1 1 ? 
ATOM   1811 C  CE2 . PHE A 1 232 ? 35.728 7.898   72.270 1.000 22.476 0 232 PHE A CE2 1 ? 
ATOM   1812 C  CZ  . PHE A 1 232 ? 34.552 8.244   71.682 1.000 21.167 0 232 PHE A CZ  1 ? 
ATOM   1813 N  N   . GLU A 1 233 ? 39.535 7.116   68.980 1.000 20.709 0 233 GLU A N   1 ? 
ATOM   1814 C  CA  . GLU A 1 233 ? 40.303 8.354   68.901 1.000 21.286 0 233 GLU A CA  1 ? 
ATOM   1815 C  C   . GLU A 1 233 ? 40.424 8.811   67.449 1.000 20.597 0 233 GLU A C   1 ? 
ATOM   1816 O  O   . GLU A 1 233 ? 40.175 9.965   67.103 1.000 19.493 0 233 GLU A O   1 ? 
ATOM   1817 C  CB  . GLU A 1 233 ? 41.691 8.153   69.521 1.000 24.102 0 233 GLU A CB  1 ? 
ATOM   1818 C  CG  . GLU A 1 233 ? 42.588 9.376   69.356 1.000 25.191 0 233 GLU A CG  1 ? 
ATOM   1819 C  CD  . GLU A 1 233 ? 44.024 9.121   69.784 1.000 29.785 0 233 GLU A CD  1 ? 
ATOM   1820 O  OE1 . GLU A 1 233 ? 44.354 8.023   70.296 1.000 31.841 0 233 GLU A OE1 1 ? 
ATOM   1821 O  OE2 . GLU A 1 233 ? 44.786 10.066  69.555 1.000 31.092 0 233 GLU A OE2 1 ? 
ATOM   1822 N  N   . ASP A 1 234 ? 40.798 7.866   66.583 1.000 21.906 0 234 ASP A N   1 ? 
ATOM   1823 C  CA  . ASP A 1 234 ? 41.067 8.154   65.191 1.000 22.187 0 234 ASP A CA  1 ? 
ATOM   1824 C  C   . ASP A 1 234 ? 39.807 8.678   64.504 1.000 18.261 0 234 ASP A C   1 ? 
ATOM   1825 O  O   . ASP A 1 234 ? 39.872 9.601   63.695 1.000 17.656 0 234 ASP A O   1 ? 
ATOM   1826 C  CB  . ASP A 1 234 ? 41.533 6.912   64.450 1.000 22.119 0 234 ASP A CB  1 ? 
ATOM   1827 C  CG  . ASP A 1 234 ? 42.896 6.367   64.853 1.000 30.373 0 234 ASP A CG  1 ? 
ATOM   1828 O  OD1 . ASP A 1 234 ? 43.703 7.145   65.411 1.000 29.605 0 234 ASP A OD1 1 ? 
ATOM   1829 O  OD2 . ASP A 1 234 ? 43.108 5.146   64.614 1.000 35.349 0 234 ASP A OD2 1 ? 
ATOM   1830 N  N   . ALA A 1 235 ? 38.636 8.191   64.921 1.000 17.701 0 235 ALA A N   1 ? 
ATOM   1831 C  CA  . ALA A 1 235 ? 37.394 8.596   64.273 1.000 18.955 0 235 ALA A CA  1 ? 
ATOM   1832 C  C   . ALA A 1 235 ? 37.050 10.022  64.714 1.000 16.994 0 235 ALA A C   1 ? 
ATOM   1833 O  O   . ALA A 1 235 ? 36.567 10.814  63.911 1.000 16.915 0 235 ALA A O   1 ? 
ATOM   1834 C  CB  . ALA A 1 235 ? 36.283 7.657   64.608 1.000 18.691 0 235 ALA A CB  1 ? 
ATOM   1835 N  N   . LEU A 1 236 ? 37.217 10.299  66.015 1.000 18.646 0 236 LEU A N   1 ? 
ATOM   1836 C  CA  . LEU A 1 236 ? 36.917 11.613  66.553 1.000 17.841 0 236 LEU A CA  1 ? 
ATOM   1837 C  C   . LEU A 1 236 ? 37.847 12.632  65.909 1.000 18.443 0 236 LEU A C   1 ? 
ATOM   1838 O  O   . LEU A 1 236 ? 37.399 13.710  65.532 1.000 15.700 0 236 LEU A O   1 ? 
ATOM   1839 C  CB  . LEU A 1 236 ? 37.047 11.658  68.081 1.000 17.683 0 236 LEU A CB  1 ? 
ATOM   1840 C  CG  . LEU A 1 236 ? 36.036 10.836  68.882 1.000 19.300 0 236 LEU A CG  1 ? 
ATOM   1841 C  CD1 . LEU A 1 236 ? 36.235 11.129  70.368 1.000 20.310 0 236 LEU A CD1 1 ? 
ATOM   1842 C  CD2 . LEU A 1 236 ? 34.632 11.089  68.455 1.000 20.965 0 236 LEU A CD2 1 ? 
ATOM   1843 N  N   . LEU A 1 237 ? 39.135 12.295  65.742 1.000 17.303 0 237 LEU A N   1 ? 
ATOM   1844 C  CA  . LEU A 1 237 ? 40.083 13.211  65.112 1.000 17.636 0 237 LEU A CA  1 ? 
ATOM   1845 C  C   . LEU A 1 237 ? 39.709 13.461  63.655 1.000 15.557 0 237 LEU A C   1 ? 
ATOM   1846 O  O   . LEU A 1 237 ? 39.815 14.589  63.141 1.000 17.616 0 237 LEU A O   1 ? 
ATOM   1847 C  CB  . LEU A 1 237 ? 41.512 12.694  65.246 1.000 20.628 0 237 LEU A CB  1 ? 
ATOM   1848 C  CG  . LEU A 1 237 ? 42.083 12.681  66.661 1.000 22.106 0 237 LEU A CG  1 ? 
ATOM   1849 C  CD1 . LEU A 1 237 ? 43.433 12.016  66.582 1.000 21.123 0 237 LEU A CD1 1 ? 
ATOM   1850 C  CD2 . LEU A 1 237 ? 42.136 14.087  67.194 1.000 23.458 0 237 LEU A CD2 1 ? 
ATOM   1851 N  N   . ALA A 1 238 ? 39.222 12.404  62.977 1.000 15.804 0 238 ALA A N   1 ? 
ATOM   1852 C  CA  . ALA A 1 238 ? 38.849 12.546  61.575 1.000 15.074 0 238 ALA A CA  1 ? 
ATOM   1853 C  C   . ALA A 1 238 ? 37.667 13.495  61.419 1.000 15.347 0 238 ALA A C   1 ? 
ATOM   1854 O  O   . ALA A 1 238 ? 37.607 14.330  60.511 1.000 17.032 0 238 ALA A O   1 ? 
ATOM   1855 C  CB  . ALA A 1 238 ? 38.563 11.207  60.942 1.000 16.592 0 238 ALA A CB  1 ? 
ATOM   1856 N  N   . ILE A 1 239 ? 36.676 13.407  62.349 1.000 16.002 0 239 ILE A N   1 ? 
ATOM   1857 C  CA  . ILE A 1 239 ? 35.556 14.325  62.311 1.000 14.615 0 239 ILE A CA  1 ? 
ATOM   1858 C  C   . ILE A 1 239 ? 36.031 15.762  62.494 1.000 12.851 0 239 ILE A C   1 ? 
ATOM   1859 O  O   . ILE A 1 239 ? 35.676 16.679  61.759 1.000 16.642 0 239 ILE A O   1 ? 
ATOM   1860 C  CB  . ILE A 1 239 ? 34.518 13.960  63.372 1.000 15.564 0 239 ILE A CB  1 ? 
ATOM   1861 C  CG1 . ILE A 1 239 ? 33.893 12.605  63.042 1.000 16.888 0 239 ILE A CG1 1 ? 
ATOM   1862 C  CG2 . ILE A 1 239 ? 33.507 15.089  63.483 1.000 17.955 0 239 ILE A CG2 1 ? 
ATOM   1863 C  CD1 . ILE A 1 239 ? 33.045 12.005  64.151 1.000 18.129 0 239 ILE A CD1 1 ? 
ATOM   1864 N  N   . VAL A 1 240 ? 36.822 15.977  63.522 1.000 14.808 0 240 VAL A N   1 ? 
ATOM   1865 C  CA  . VAL A 1 240 ? 37.312 17.329  63.802 1.000 15.781 0 240 VAL A CA  1 ? 
ATOM   1866 C  C   . VAL A 1 240 ? 38.097 17.888  62.613 1.000 13.857 0 240 VAL A C   1 ? 
ATOM   1867 O  O   . VAL A 1 240 ? 37.868 19.007  62.184 1.000 15.169 0 240 VAL A O   1 ? 
ATOM   1868 C  CB  . VAL A 1 240 ? 38.178 17.333  65.063 1.000 16.198 0 240 VAL A CB  1 ? 
ATOM   1869 C  CG1 . VAL A 1 240 ? 38.865 18.706  65.234 1.000 17.716 0 240 VAL A CG1 1 ? 
ATOM   1870 C  CG2 . VAL A 1 240 ? 37.338 16.975  66.293 1.000 18.936 0 240 VAL A CG2 1 ? 
ATOM   1871 N  N   . LYS A 1 241 ? 38.991 17.095  62.071 1.000 15.718 0 241 LYS A N   1 ? 
ATOM   1872 C  CA  . LYS A 1 241 ? 39.837 17.540  60.968 1.000 15.749 0 241 LYS A CA  1 ? 
ATOM   1873 C  C   . LYS A 1 241 ? 39.011 17.805  59.727 1.000 17.574 0 241 LYS A C   1 ? 
ATOM   1874 O  O   . LYS A 1 241 ? 39.211 18.797  59.038 1.000 17.874 0 241 LYS A O   1 ? 
ATOM   1875 C  CB  . LYS A 1 241 ? 40.920 16.515  60.649 1.000 16.762 0 241 LYS A CB  1 ? 
ATOM   1876 C  CG  . LYS A 1 241 ? 41.928 16.424  61.735 1.000 19.356 0 241 LYS A CG  1 ? 
ATOM   1877 C  CD  . LYS A 1 241 ? 42.846 15.221  61.595 1.000 23.738 0 241 LYS A CD  1 ? 
ATOM   1878 C  CE  . LYS A 1 241 ? 43.893 15.351  62.630 1.000 26.710 0 241 LYS A CE  1 ? 
ATOM   1879 N  NZ  . LYS A 1 241 ? 44.834 14.246  62.504 1.000 35.774 0 241 LYS A NZ  1 ? 
ATOM   1880 N  N   . CYS A 1 242 ? 38.038 16.966  59.468 1.000 16.573 0 242 CYS A N   1 ? 
ATOM   1881 C  CA  . CYS A 1 242 ? 37.174 17.197  58.322 1.000 16.040 0 242 CYS A CA  1 ? 
ATOM   1882 C  C   . CYS A 1 242 ? 36.268 18.408  58.494 1.000 18.518 0 242 CYS A C   1 ? 
ATOM   1883 O  O   . CYS A 1 242 ? 35.906 19.046  57.501 1.000 19.416 0 242 CYS A O   1 ? 
ATOM   1884 C  CB  . CYS A 1 242 ? 36.361 15.959  57.943 1.000 16.440 0 242 CYS A CB  1 ? 
ATOM   1885 S  SG  . CYS A 1 242 ? 37.430 14.708  57.172 1.000 18.117 0 242 CYS A SG  1 ? 
ATOM   1886 N  N   . MET A 1 243 ? 35.837 18.718  59.730 1.000 16.909 0 243 MET A N   1 ? 
ATOM   1887 C  CA  . MET A 1 243 ? 35.032 19.899  59.949 1.000 16.478 0 243 MET A CA  1 ? 
ATOM   1888 C  C   . MET A 1 243 ? 35.877 21.171  59.760 1.000 17.326 0 243 MET A C   1 ? 
ATOM   1889 O  O   . MET A 1 243 ? 35.366 22.158  59.225 1.000 19.435 0 243 MET A O   1 ? 
ATOM   1890 C  CB  . MET A 1 243 ? 34.437 19.876  61.353 1.000 17.465 0 243 MET A CB  1 ? 
ATOM   1891 C  CG  . MET A 1 243 ? 33.405 18.809  61.588 1.000 18.812 0 243 MET A CG  1 ? 
ATOM   1892 S  SD  . MET A 1 243 ? 31.893 19.251  60.745 1.000 22.091 0 243 MET A SD  1 ? 
ATOM   1893 C  CE  . MET A 1 243 ? 31.003 17.709  61.027 1.000 20.292 0 243 MET A CE  1 ? 
ATOM   1894 N  N   . ARG A 1 244 ? 37.148 21.122  60.153 1.000 18.453 0 244 ARG A N   1 ? 
ATOM   1895 C  CA  . ARG A 1 244 ? 38.021 22.288  60.021 1.000 20.523 0 244 ARG A CA  1 ? 
ATOM   1896 C  C   . ARG A 1 244 ? 38.434 22.476  58.567 1.000 22.255 0 244 ARG A C   1 ? 
ATOM   1897 O  O   . ARG A 1 244 ? 38.319 23.567  58.020 1.000 23.073 0 244 ARG A O   1 ? 
ATOM   1898 C  CB  . ARG A 1 244 ? 39.272 22.133  60.887 1.000 23.355 0 244 ARG A CB  1 ? 
ATOM   1899 C  CG  . ARG A 1 244 ? 39.077 22.320  62.386 1.000 25.762 0 244 ARG A CG  1 ? 
ATOM   1900 C  CD  . ARG A 1 244 ? 40.400 22.225  63.101 1.000 27.685 0 244 ARG A CD  1 ? 
ATOM   1901 N  NE  . ARG A 1 244 ? 40.489 22.123  64.557 1.000 30.176 0 244 ARG A NE  1 ? 
ATOM   1902 C  CZ  . ARG A 1 244 ? 40.167 23.065  65.416 1.000 33.045 0 244 ARG A CZ  1 ? 
ATOM   1903 N  NH1 . ARG A 1 244 ? 39.564 24.152  64.987 1.000 36.799 0 244 ARG A NH1 1 ? 
ATOM   1904 N  NH2 . ARG A 1 244 ? 40.458 22.919  66.704 1.000 33.840 0 244 ARG A NH2 1 ? 
ATOM   1905 N  N   . ASN A 1 245 ? 38.974 21.425  57.936 1.000 19.498 0 245 ASN A N   1 ? 
ATOM   1906 C  CA  . ASN A 1 245 ? 39.512 21.580  56.583 1.000 19.377 0 245 ASN A CA  1 ? 
ATOM   1907 C  C   . ASN A 1 245 ? 39.777 20.205  55.979 1.000 16.744 0 245 ASN A C   1 ? 
ATOM   1908 O  O   . ASN A 1 245 ? 40.749 19.540  56.388 1.000 18.471 0 245 ASN A O   1 ? 
ATOM   1909 C  CB  . ASN A 1 245 ? 40.796 22.382  56.567 1.000 23.597 0 245 ASN A CB  1 ? 
ATOM   1910 C  CG  . ASN A 1 245 ? 41.160 22.736  55.136 1.000 25.155 0 245 ASN A CG  1 ? 
ATOM   1911 O  OD1 . ASN A 1 245 ? 41.373 21.859  54.297 1.000 24.496 0 245 ASN A OD1 1 ? 
ATOM   1912 N  ND2 . ASN A 1 245 ? 41.148 24.011  54.797 1.000 27.103 0 245 ASN A ND2 1 ? 
ATOM   1913 N  N   . LYS A 1 246 ? 38.873 19.767  55.110 1.000 19.434 0 246 LYS A N   1 ? 
ATOM   1914 C  CA  . LYS A 1 246 ? 38.946 18.388  54.633 1.000 17.000 0 246 LYS A CA  1 ? 
ATOM   1915 C  C   . LYS A 1 246 ? 40.157 18.179  53.727 1.000 15.662 0 246 LYS A C   1 ? 
ATOM   1916 O  O   . LYS A 1 246 ? 40.732 17.083  53.689 1.000 17.709 0 246 LYS A O   1 ? 
ATOM   1917 C  CB  . LYS A 1 246 ? 37.774 18.059  53.698 1.000 21.549 0 246 LYS A CB  1 ? 
ATOM   1918 C  CG  . LYS A 1 246 ? 36.513 17.821  54.427 1.000 26.691 0 246 LYS A CG  1 ? 
ATOM   1919 C  CD  . LYS A 1 246 ? 35.353 17.578  53.472 1.000 24.134 0 246 LYS A CD  1 ? 
ATOM   1920 C  CE  . LYS A 1 246 ? 34.113 17.741  54.245 1.000 25.981 0 246 LYS A CE  1 ? 
ATOM   1921 N  NZ  . LYS A 1 246 ? 32.975 17.198  53.539 1.000 25.446 0 246 LYS A NZ  1 ? 
ATOM   1922 N  N   . SER A 1 247 ? 40.532 19.240  53.000 1.000 17.186 0 247 SER A N   1 ? 
ATOM   1923 C  CA  . SER A 1 247 ? 41.754 19.183  52.184 1.000 18.015 0 247 SER A CA  1 ? 
ATOM   1924 C  C   . SER A 1 247 ? 42.978 18.829  53.022 1.000 19.293 0 247 SER A C   1 ? 
ATOM   1925 O  O   . SER A 1 247 ? 43.817 18.054  52.591 1.000 18.078 0 247 SER A O   1 ? 
ATOM   1926 C  CB  . SER A 1 247 ? 41.961 20.463  51.448 1.000 20.598 0 247 SER A CB  1 ? 
ATOM   1927 O  OG  . SER A 1 247 ? 40.944 20.582  50.476 1.000 23.334 0 247 SER A OG  1 ? 
ATOM   1928 N  N   . ALA A 1 248 ? 43.134 19.485  54.180 1.000 18.954 0 248 ALA A N   1 ? 
ATOM   1929 C  CA  . ALA A 1 248 ? 44.227 19.178  55.063 1.000 18.489 0 248 ALA A CA  1 ? 
ATOM   1930 C  C   . ALA A 1 248 ? 44.199 17.723  55.551 1.000 17.983 0 248 ALA A C   1 ? 
ATOM   1931 O  O   . ALA A 1 248 ? 45.212 17.070  55.710 1.000 17.762 0 248 ALA A O   1 ? 
ATOM   1932 C  CB  . ALA A 1 248 ? 44.276 20.205  56.174 1.000 20.175 0 248 ALA A CB  1 ? 
ATOM   1933 N  N   . TYR A 1 249 ? 43.003 17.230  55.885 1.000 15.943 0 249 TYR A N   1 ? 
ATOM   1934 C  CA  . TYR A 1 249 ? 42.823 15.860  56.315 1.000 15.059 0 249 TYR A CA  1 ? 
ATOM   1935 C  C   . TYR A 1 249 ? 43.341 14.899  55.256 1.000 15.330 0 249 TYR A C   1 ? 
ATOM   1936 O  O   . TYR A 1 249 ? 44.053 13.939  55.536 1.000 15.560 0 249 TYR A O   1 ? 
ATOM   1937 C  CB  . TYR A 1 249 ? 41.321 15.670  56.585 1.000 15.855 0 249 TYR A CB  1 ? 
ATOM   1938 C  CG  . TYR A 1 249 ? 40.942 14.228  56.888 1.000 16.389 0 249 TYR A CG  1 ? 
ATOM   1939 C  CD1 . TYR A 1 249 ? 41.334 13.628  58.077 1.000 16.425 0 249 TYR A CD1 1 ? 
ATOM   1940 C  CD2 . TYR A 1 249 ? 40.329 13.443  55.931 1.000 17.048 0 249 TYR A CD2 1 ? 
ATOM   1941 C  CE1 . TYR A 1 249 ? 41.078 12.292  58.329 1.000 15.941 0 249 TYR A CE1 1 ? 
ATOM   1942 C  CE2 . TYR A 1 249 ? 40.026 12.118  56.196 1.000 17.038 0 249 TYR A CE2 1 ? 
ATOM   1943 C  CZ  . TYR A 1 249 ? 40.358 11.564  57.409 1.000 15.015 0 249 TYR A CZ  1 ? 
ATOM   1944 O  OH  . TYR A 1 249 ? 40.141 10.227  57.685 1.000 20.020 0 249 TYR A OH  1 ? 
ATOM   1945 N  N   . PHE A 1 250 ? 42.915 15.152  54.021 1.000 14.928 0 250 PHE A N   1 ? 
ATOM   1946 C  CA  . PHE A 1 250 ? 43.371 14.262  52.966 1.000 15.237 0 250 PHE A CA  1 ? 
ATOM   1947 C  C   . PHE A 1 250 ? 44.868 14.394  52.660 1.000 15.431 0 250 PHE A C   1 ? 
ATOM   1948 O  O   . PHE A 1 250 ? 45.522 13.413  52.359 1.000 15.376 0 250 PHE A O   1 ? 
ATOM   1949 C  CB  . PHE A 1 250 ? 42.628 14.494  51.654 1.000 12.870 0 250 PHE A CB  1 ? 
ATOM   1950 C  CG  . PHE A 1 250 ? 41.216 13.911  51.716 1.000 15.187 0 250 PHE A CG  1 ? 
ATOM   1951 C  CD1 . PHE A 1 250 ? 41.037 12.532  51.776 1.000 15.150 0 250 PHE A CD1 1 ? 
ATOM   1952 C  CD2 . PHE A 1 250 ? 40.098 14.697  51.765 1.000 16.990 0 250 PHE A CD2 1 ? 
ATOM   1953 C  CE1 . PHE A 1 250 ? 39.775 11.958  51.921 1.000 17.580 0 250 PHE A CE1 1 ? 
ATOM   1954 C  CE2 . PHE A 1 250 ? 38.838 14.123  51.885 1.000 16.200 0 250 PHE A CE2 1 ? 
ATOM   1955 C  CZ  . PHE A 1 250 ? 38.687 12.756  51.969 1.000 16.109 0 250 PHE A CZ  1 ? 
ATOM   1956 N  N   . ALA A 1 251 ? 45.473 15.589  52.832 1.000 16.376 0 251 ALA A N   1 ? 
ATOM   1957 C  CA  . ALA A 1 251 ? 46.946 15.681  52.778 1.000 15.133 0 251 ALA A CA  1 ? 
ATOM   1958 C  C   . ALA A 1 251 ? 47.605 14.744  53.798 1.000 16.079 0 251 ALA A C   1 ? 
ATOM   1959 O  O   . ALA A 1 251 ? 48.569 14.086  53.493 1.000 17.264 0 251 ALA A O   1 ? 
ATOM   1960 C  CB  . ALA A 1 251 ? 47.438 17.108  53.024 1.000 16.195 0 251 ALA A CB  1 ? 
ATOM   1961 N  N   . GLU A 1 252 ? 47.109 14.764  55.052 1.000 17.541 0 252 GLU A N   1 ? 
ATOM   1962 C  CA  . GLU A 1 252 ? 47.591 13.900  56.108 1.000 19.010 0 252 GLU A CA  1 ? 
ATOM   1963 C  C   . GLU A 1 252 ? 47.412 12.430  55.726 1.000 19.971 0 252 GLU A C   1 ? 
ATOM   1964 O  O   . GLU A 1 252 ? 48.331 11.665  55.943 1.000 16.769 0 252 GLU A O   1 ? 
ATOM   1965 C  CB  . GLU A 1 252 ? 46.850 14.218  57.420 1.000 19.268 0 252 GLU A CB  1 ? 
ATOM   1966 C  CG  . GLU A 1 252 ? 47.309 13.357  58.593 1.000 25.705 0 252 GLU A CG  1 ? 
ATOM   1967 C  CD  . GLU A 1 252 ? 46.357 13.423  59.797 1.000 32.891 0 252 GLU A CD  1 ? 
ATOM   1968 O  OE1 . GLU A 1 252 ? 46.082 14.577  60.154 1.000 29.410 0 252 GLU A OE1 1 ? 
ATOM   1969 O  OE2 . GLU A 1 252 ? 45.856 12.367  60.317 1.000 40.039 0 252 GLU A OE2 1 ? 
ATOM   1970 N  N   . LYS A 1 253 ? 46.271 12.069  55.130 1.000 17.557 0 253 LYS A N   1 ? 
ATOM   1971 C  CA  . LYS A 1 253 ? 46.030 10.679  54.728 1.000 15.481 0 253 LYS A CA  1 ? 
ATOM   1972 C  C   . LYS A 1 253 ? 47.056 10.220  53.667 1.000 15.321 0 253 LYS A C   1 ? 
ATOM   1973 O  O   . LYS A 1 253 ? 47.603 9.115   53.715 1.000 16.035 0 253 LYS A O   1 ? 
ATOM   1974 C  CB  . LYS A 1 253 ? 44.636 10.429  54.161 1.000 17.040 0 253 LYS A CB  1 ? 
ATOM   1975 C  CG  . LYS A 1 253 ? 43.561 10.615  55.249 1.000 19.209 0 253 LYS A CG  1 ? 
ATOM   1976 C  CD  . LYS A 1 253 ? 43.533 9.498   56.280 1.000 25.320 0 253 LYS A CD  1 ? 
ATOM   1977 C  CE  . LYS A 1 253 ? 43.669 8.034   55.782 1.000 27.793 0 253 LYS A CE  1 ? 
ATOM   1978 N  NZ  . LYS A 1 253 ? 42.644 7.029   55.413 1.000 26.506 0 253 LYS A NZ  1 ? 
ATOM   1979 N  N   . LEU A 1 254 ? 47.337 11.105  52.726 1.000 14.347 0 254 LEU A N   1 ? 
ATOM   1980 C  CA  . LEU A 1 254 ? 48.353 10.836  51.705 1.000 16.382 0 254 LEU A CA  1 ? 
ATOM   1981 C  C   . LEU A 1 254 ? 49.755 10.709  52.311 1.000 17.014 0 254 LEU A C   1 ? 
ATOM   1982 O  O   . LEU A 1 254 ? 50.473 9.760   51.995 1.000 18.432 0 254 LEU A O   1 ? 
ATOM   1983 C  CB  . LEU A 1 254 ? 48.280 11.919  50.640 1.000 15.778 0 254 LEU A CB  1 ? 
ATOM   1984 C  CG  . LEU A 1 254 ? 47.087 11.833  49.706 1.000 16.760 0 254 LEU A CG  1 ? 
ATOM   1985 C  CD1 . LEU A 1 254 ? 46.878 13.139  49.008 1.000 16.479 0 254 LEU A CD1 1 ? 
ATOM   1986 C  CD2 . LEU A 1 254 ? 47.084 10.671  48.729 1.000 17.971 0 254 LEU A CD2 1 ? 
ATOM   1987 N  N   . TYR A 1 255 ? 50.139 11.665  53.169 1.000 15.300 0 255 TYR A N   1 ? 
ATOM   1988 C  CA  . TYR A 1 255 ? 51.406 11.585  53.864 1.000 18.571 0 255 TYR A CA  1 ? 
ATOM   1989 C  C   . TYR A 1 255 ? 51.554 10.247  54.574 1.000 18.348 0 255 TYR A C   1 ? 
ATOM   1990 O  O   . TYR A 1 255 ? 52.553 9.574   54.403 1.000 18.704 0 255 TYR A O   1 ? 
ATOM   1991 C  CB  . TYR A 1 255 ? 51.520 12.802  54.771 1.000 17.622 0 255 TYR A CB  1 ? 
ATOM   1992 C  CG  . TYR A 1 255 ? 52.775 12.787  55.619 1.000 17.879 0 255 TYR A CG  1 ? 
ATOM   1993 C  CD1 . TYR A 1 255 ? 53.987 13.203  55.082 1.000 20.135 0 255 TYR A CD1 1 ? 
ATOM   1994 C  CD2 . TYR A 1 255 ? 52.761 12.295  56.915 1.000 21.236 0 255 TYR A CD2 1 ? 
ATOM   1995 C  CE1 . TYR A 1 255 ? 55.158 13.193  55.832 1.000 22.799 0 255 TYR A CE1 1 ? 
ATOM   1996 C  CE2 . TYR A 1 255 ? 53.920 12.293  57.679 1.000 22.031 0 255 TYR A CE2 1 ? 
ATOM   1997 C  CZ  . TYR A 1 255 ? 55.120 12.739  57.132 1.000 25.507 0 255 TYR A CZ  1 ? 
ATOM   1998 O  OH  . TYR A 1 255 ? 56.278 12.741  57.868 1.000 26.786 0 255 TYR A OH  1 ? 
ATOM   1999 N  N   . LYS A 1 256 ? 50.517 9.854   55.330 1.000 17.955 0 256 LYS A N   1 ? 
ATOM   2000 C  CA  . LYS A 1 256 ? 50.662 8.640   56.116 1.000 18.388 0 256 LYS A CA  1 ? 
ATOM   2001 C  C   . LYS A 1 256 ? 50.723 7.419   55.209 1.000 17.389 0 256 LYS A C   1 ? 
ATOM   2002 O  O   . LYS A 1 256 ? 51.292 6.400   55.602 1.000 20.110 0 256 LYS A O   1 ? 
ATOM   2003 C  CB  . LYS A 1 256 ? 49.543 8.601   57.157 1.000 20.119 0 256 LYS A CB  1 ? 
ATOM   2004 C  CG  . LYS A 1 256 ? 49.793 9.631   58.229 1.000 21.954 0 256 LYS A CG  1 ? 
ATOM   2005 C  CD  . LYS A 1 256 ? 48.740 9.618   59.343 1.000 27.622 0 256 LYS A CD  1 ? 
ATOM   2006 C  CE  . LYS A 1 256 ? 49.195 10.397  60.534 1.000 30.905 0 256 LYS A CE  1 ? 
ATOM   2007 N  NZ  . LYS A 1 256 ? 48.116 10.513  61.534 1.000 34.425 0 256 LYS A NZ  1 ? 
ATOM   2008 N  N   . SER A 1 257 ? 50.080 7.480   54.026 1.000 16.800 0 257 SER A N   1 ? 
ATOM   2009 C  CA  . SER A 1 257 ? 50.068 6.323   53.156 1.000 16.444 0 257 SER A CA  1 ? 
ATOM   2010 C  C   . SER A 1 257 ? 51.449 6.056   52.549 1.000 16.633 0 257 SER A C   1 ? 
ATOM   2011 O  O   . SER A 1 257 ? 51.650 4.961   52.049 1.000 18.599 0 257 SER A O   1 ? 
ATOM   2012 C  CB  . SER A 1 257 ? 49.084 6.451   52.037 1.000 15.911 0 257 SER A CB  1 ? 
ATOM   2013 O  OG  . SER A 1 257 ? 49.477 7.375   51.048 1.000 17.339 0 257 SER A OG  1 ? 
ATOM   2014 N  N   . MET A 1 258 ? 52.327 7.058   52.553 1.000 18.148 0 258 MET A N   1 ? 
ATOM   2015 C  CA  . MET A 1 258 ? 53.603 6.952   51.834 1.000 16.812 0 258 MET A CA  1 ? 
ATOM   2016 C  C   . MET A 1 258 ? 54.830 7.058   52.734 1.000 19.735 0 258 MET A C   1 ? 
ATOM   2017 O  O   . MET A 1 258 ? 55.879 6.528   52.383 1.000 20.096 0 258 MET A O   1 ? 
ATOM   2018 C  CB  . MET A 1 258 ? 53.663 8.011   50.743 1.000 18.072 0 258 MET A CB  1 ? 
ATOM   2019 C  CG  . MET A 1 258 ? 52.885 7.647   49.526 1.000 18.399 0 258 MET A CG  1 ? 
ATOM   2020 S  SD  . MET A 1 258 ? 52.838 8.913   48.234 1.000 18.128 0 258 MET A SD  1 ? 
ATOM   2021 C  CE  . MET A 1 258 ? 51.735 10.160  48.938 1.000 17.973 0 258 MET A CE  1 ? 
ATOM   2022 N  N   . LYS A 1 259 ? 54.706 7.718   53.878 1.000 23.384 0 259 LYS A N   1 ? 
ATOM   2023 C  CA  . LYS A 1 259 ? 55.851 8.107   54.667 1.000 27.357 0 259 LYS A CA  1 ? 
ATOM   2024 C  C   . LYS A 1 259 ? 56.586 6.915   55.260 1.000 30.944 0 259 LYS A C   1 ? 
ATOM   2025 O  O   . LYS A 1 259 ? 57.805 6.986   55.424 1.000 34.541 0 259 LYS A O   1 ? 
ATOM   2026 C  CB  . LYS A 1 259 ? 55.484 9.076   55.792 1.000 27.454 0 259 LYS A CB  1 ? 
ATOM   2027 C  CG  . LYS A 1 259 ? 56.703 9.663   56.546 1.000 34.103 0 259 LYS A CG  1 ? 
ATOM   2028 C  CD  . LYS A 1 259 ? 57.768 10.428  55.742 1.000 35.657 0 259 LYS A CD  1 ? 
ATOM   2029 C  CE  . LYS A 1 259 ? 58.765 11.120  56.646 1.000 38.448 0 259 LYS A CE  1 ? 
ATOM   2030 N  NZ  . LYS A 1 259 ? 59.903 11.749  55.958 1.000 42.097 0 259 LYS A NZ  1 ? 
ATOM   2031 N  N   . GLY A 1 260 ? 55.919 5.799   55.493 1.000 29.694 0 260 GLY A N   1 ? 
ATOM   2032 C  CA  . GLY A 1 260 ? 56.649 4.655   56.040 1.000 40.492 0 260 GLY A CA  1 ? 
ATOM   2033 C  C   . GLY A 1 260 ? 57.575 3.941   55.041 1.000 38.566 0 260 GLY A C   1 ? 
ATOM   2034 O  O   . GLY A 1 260 ? 57.744 4.324   53.873 1.000 28.952 0 260 GLY A O   1 ? 
ATOM   2035 N  N   . LEU A 1 261 ? 58.137 2.831   55.526 1.000 40.211 0 261 LEU A N   1 ? 
ATOM   2036 C  CA  . LEU A 1 261 ? 58.582 1.748   54.675 1.000 40.726 0 261 LEU A CA  1 ? 
ATOM   2037 C  C   . LEU A 1 261 ? 57.364 1.243   53.902 1.000 36.029 0 261 LEU A C   1 ? 
ATOM   2038 O  O   . LEU A 1 261 ? 56.353 0.905   54.492 1.000 39.839 0 261 LEU A O   1 ? 
ATOM   2039 C  CB  . LEU A 1 261 ? 59.191 0.615   55.508 1.000 42.698 0 261 LEU A CB  1 ? 
ATOM   2040 C  CG  . LEU A 1 261 ? 59.872 -0.500  54.699 1.000 53.887 0 261 LEU A CG  1 ? 
ATOM   2041 C  CD1 . LEU A 1 261 ? 60.911 0.044   53.724 1.000 50.278 0 261 LEU A CD1 1 ? 
ATOM   2042 C  CD2 . LEU A 1 261 ? 60.514 -1.541  55.609 1.000 57.685 0 261 LEU A CD2 1 ? 
ATOM   2043 N  N   . GLY A 1 262 ? 57.482 1.199   52.581 1.000 33.487 0 262 GLY A N   1 ? 
ATOM   2044 C  CA  . GLY A 1 262 ? 56.414 0.717   51.732 1.000 30.942 0 262 GLY A CA  1 ? 
ATOM   2045 C  C   . GLY A 1 262 ? 55.314 1.765   51.551 1.000 26.951 0 262 GLY A C   1 ? 
ATOM   2046 O  O   . GLY A 1 262 ? 55.522 2.967   51.782 1.000 26.800 0 262 GLY A O   1 ? 
ATOM   2047 N  N   . THR A 1 263 ? 54.154 1.295   51.085 1.000 24.065 0 263 THR A N   1 ? 
ATOM   2048 C  CA  . THR A 1 263 ? 53.100 2.202   50.661 1.000 22.167 0 263 THR A CA  1 ? 
ATOM   2049 C  C   . THR A 1 263 ? 51.753 1.554   50.950 1.000 20.230 0 263 THR A C   1 ? 
ATOM   2050 O  O   . THR A 1 263 ? 51.548 0.382   50.610 1.000 21.586 0 263 THR A O   1 ? 
ATOM   2051 C  CB  . THR A 1 263 ? 53.188 2.445   49.167 1.000 21.700 0 263 THR A CB  1 ? 
ATOM   2052 O  OG1 . THR A 1 263 ? 54.494 2.923   48.862 1.000 25.646 0 263 THR A OG1 1 ? 
ATOM   2053 C  CG2 . THR A 1 263 ? 52.168 3.473   48.731 1.000 21.149 0 263 THR A CG2 1 ? 
ATOM   2054 N  N   . ASP A 1 264 ? 50.851 2.317   51.562 1.000 18.916 0 264 ASP A N   1 ? 
ATOM   2055 C  CA  . ASP A 1 264 ? 49.465 1.925   51.643 1.000 16.979 0 264 ASP A CA  1 ? 
ATOM   2056 C  C   . ASP A 1 264 ? 48.781 2.256   50.317 1.000 15.700 0 264 ASP A C   1 ? 
ATOM   2057 O  O   . ASP A 1 264 ? 48.161 3.319   50.181 1.000 16.753 0 264 ASP A O   1 ? 
ATOM   2058 C  CB  . ASP A 1 264 ? 48.824 2.517   52.875 1.000 17.546 0 264 ASP A CB  1 ? 
ATOM   2059 C  CG  . ASP A 1 264 ? 47.340 2.231   53.066 1.000 19.039 0 264 ASP A CG  1 ? 
ATOM   2060 O  OD1 . ASP A 1 264 ? 46.784 1.439   52.260 1.000 18.464 0 264 ASP A OD1 1 ? 
ATOM   2061 O  OD2 . ASP A 1 264 ? 46.743 2.809   53.990 1.000 20.335 0 264 ASP A OD2 1 ? 
ATOM   2062 N  N   . ASP A 1 265 ? 48.891 1.338   49.345 1.000 18.430 0 265 ASP A N   1 ? 
ATOM   2063 C  CA  . ASP A 1 265 ? 48.369 1.623   48.004 1.000 18.110 0 265 ASP A CA  1 ? 
ATOM   2064 C  C   . ASP A 1 265 ? 46.863 1.830   48.007 1.000 17.323 0 265 ASP A C   1 ? 
ATOM   2065 O  O   . ASP A 1 265 ? 46.383 2.688   47.268 1.000 14.993 0 265 ASP A O   1 ? 
ATOM   2066 C  CB  . ASP A 1 265 ? 48.788 0.573   47.004 1.000 18.970 0 265 ASP A CB  1 ? 
ATOM   2067 C  CG  . ASP A 1 265 ? 50.300 0.482   46.802 1.000 20.724 0 265 ASP A CG  1 ? 
ATOM   2068 O  OD1 . ASP A 1 265 ? 50.922 1.434   46.334 1.000 20.972 0 265 ASP A OD1 1 ? 
ATOM   2069 O  OD2 . ASP A 1 265 ? 50.842 -0.541  47.193 1.000 26.841 0 265 ASP A OD2 1 ? 
ATOM   2070 N  N   . ASN A 1 266 ? 46.102 1.019   48.757 1.000 16.877 0 266 ASN A N   1 ? 
ATOM   2071 C  CA  . ASN A 1 266 ? 44.651 1.158   48.769 1.000 17.291 0 266 ASN A CA  1 ? 
ATOM   2072 C  C   . ASN A 1 266 ? 44.257 2.573   49.175 1.000 16.571 0 266 ASN A C   1 ? 
ATOM   2073 O  O   . ASN A 1 266 ? 43.389 3.170   48.533 1.000 16.983 0 266 ASN A O   1 ? 
ATOM   2074 C  CB  . ASN A 1 266 ? 44.012 0.130   49.688 1.000 21.393 0 266 ASN A CB  1 ? 
ATOM   2075 C  CG  . ASN A 1 266 ? 44.025 -1.262  49.141 1.000 24.429 0 266 ASN A CG  1 ? 
ATOM   2076 O  OD1 . ASN A 1 266 ? 44.141 -2.219  49.918 1.000 29.617 0 266 ASN A OD1 1 ? 
ATOM   2077 N  ND2 . ASN A 1 266 ? 43.868 -1.404  47.849 1.000 21.001 0 266 ASN A ND2 1 ? 
ATOM   2078 N  N   . THR A 1 267 ? 44.939 3.167   50.182 1.000 16.318 0 267 THR A N   1 ? 
ATOM   2079 C  CA  . THR A 1 267 ? 44.582 4.509   50.629 1.000 16.274 0 267 THR A CA  1 ? 
ATOM   2080 C  C   . THR A 1 267 ? 45.033 5.548   49.594 1.000 15.854 0 267 THR A C   1 ? 
ATOM   2081 O  O   . THR A 1 267 ? 44.288 6.481   49.245 1.000 16.000 0 267 THR A O   1 ? 
ATOM   2082 C  CB  . THR A 1 267 ? 45.215 4.781   51.996 1.000 17.260 0 267 THR A CB  1 ? 
ATOM   2083 O  OG1 . THR A 1 267 ? 44.555 3.885   52.904 1.000 17.809 0 267 THR A OG1 1 ? 
ATOM   2084 C  CG2 . THR A 1 267 ? 44.966 6.202   52.442 1.000 17.493 0 267 THR A CG2 1 ? 
ATOM   2085 N  N   . LEU A 1 268 ? 46.283 5.407   49.128 1.000 16.379 0 268 LEU A N   1 ? 
ATOM   2086 C  CA  . LEU A 1 268 ? 46.820 6.342   48.154 1.000 15.131 0 268 LEU A CA  1 ? 
ATOM   2087 C  C   . LEU A 1 268 ? 45.893 6.400   46.924 1.000 13.460 0 268 LEU A C   1 ? 
ATOM   2088 O  O   . LEU A 1 268 ? 45.601 7.489   46.460 1.000 15.352 0 268 LEU A O   1 ? 
ATOM   2089 C  CB  . LEU A 1 268 ? 48.229 5.885   47.775 1.000 16.361 0 268 LEU A CB  1 ? 
ATOM   2090 C  CG  . LEU A 1 268 ? 48.882 6.649   46.640 1.000 16.677 0 268 LEU A CG  1 ? 
ATOM   2091 C  CD1 . LEU A 1 268 ? 48.882 8.130   46.926 1.000 17.054 0 268 LEU A CD1 1 ? 
ATOM   2092 C  CD2 . LEU A 1 268 ? 50.297 6.071   46.399 1.000 16.555 0 268 LEU A CD2 1 ? 
ATOM   2093 N  N   . ILE A 1 269 ? 45.577 5.241   46.366 1.000 13.176 0 269 ILE A N   1 ? 
ATOM   2094 C  CA  . ILE A 1 269 ? 44.717 5.160   45.203 1.000 14.470 0 269 ILE A CA  1 ? 
ATOM   2095 C  C   . ILE A 1 269 ? 43.371 5.789   45.503 1.000 15.353 0 269 ILE A C   1 ? 
ATOM   2096 O  O   . ILE A 1 269 ? 42.944 6.649   44.724 1.000 13.619 0 269 ILE A O   1 ? 
ATOM   2097 C  CB  . ILE A 1 269 ? 44.591 3.706   44.741 1.000 14.438 0 269 ILE A CB  1 ? 
ATOM   2098 C  CG1 . ILE A 1 269 ? 45.970 3.224   44.202 1.000 16.086 0 269 ILE A CG1 1 ? 
ATOM   2099 C  CG2 . ILE A 1 269 ? 43.502 3.509   43.691 1.000 15.548 0 269 ILE A CG2 1 ? 
ATOM   2100 C  CD1 . ILE A 1 269 ? 45.987 1.754   43.845 1.000 17.091 0 269 ILE A CD1 1 ? 
ATOM   2101 N  N   . ARG A 1 270 ? 42.704 5.409   46.593 1.000 15.809 0 270 ARG A N   1 ? 
ATOM   2102 C  CA  . ARG A 1 270 ? 41.366 5.935   46.828 1.000 15.614 0 270 ARG A CA  1 ? 
ATOM   2103 C  C   . ARG A 1 270 ? 41.363 7.458   46.958 1.000 15.063 0 270 ARG A C   1 ? 
ATOM   2104 O  O   . ARG A 1 270 ? 40.466 8.108   46.430 1.000 16.684 0 270 ARG A O   1 ? 
ATOM   2105 C  CB  . ARG A 1 270 ? 40.734 5.215   48.033 1.000 17.056 0 270 ARG A CB  1 ? 
ATOM   2106 C  CG  . ARG A 1 270 ? 39.410 5.798   48.457 1.000 17.172 0 270 ARG A CG  1 ? 
ATOM   2107 C  CD  . ARG A 1 270 ? 38.757 5.092   49.652 1.000 16.603 0 270 ARG A CD  1 ? 
ATOM   2108 N  NE  . ARG A 1 270 ? 39.684 5.218   50.784 1.000 17.729 0 270 ARG A NE  1 ? 
ATOM   2109 C  CZ  . ARG A 1 270 ? 40.444 4.292   51.264 1.000 19.053 0 270 ARG A CZ  1 ? 
ATOM   2110 N  NH1 . ARG A 1 270 ? 40.487 3.079   50.751 1.000 19.559 0 270 ARG A NH1 1 ? 
ATOM   2111 N  NH2 . ARG A 1 270 ? 41.224 4.577   52.285 1.000 19.867 0 270 ARG A NH2 1 ? 
ATOM   2112 N  N   . VAL A 1 271 ? 42.344 7.991   47.707 1.000 14.301 0 271 VAL A N   1 ? 
ATOM   2113 C  CA  . VAL A 1 271 ? 42.344 9.428   47.911 1.000 15.738 0 271 VAL A CA  1 ? 
ATOM   2114 C  C   . VAL A 1 271 ? 42.585 10.114  46.582 1.000 15.073 0 271 VAL A C   1 ? 
ATOM   2115 O  O   . VAL A 1 271 ? 41.910 11.101  46.257 1.000 15.731 0 271 VAL A O   1 ? 
ATOM   2116 C  CB  . VAL A 1 271 ? 43.353 9.827   48.971 1.000 14.860 0 271 VAL A CB  1 ? 
ATOM   2117 C  CG1 . VAL A 1 271 ? 43.562 11.337  49.033 1.000 16.050 0 271 VAL A CG1 1 ? 
ATOM   2118 C  CG2 . VAL A 1 271 ? 42.934 9.255   50.297 1.000 16.846 0 271 VAL A CG2 1 ? 
ATOM   2119 N  N   . MET A 1 272 ? 43.600 9.637   45.858 1.000 13.717 0 272 MET A N   1 ? 
ATOM   2120 C  CA  . MET A 1 272 ? 43.890 10.326  44.610 1.000 14.080 0 272 MET A CA  1 ? 
ATOM   2121 C  C   . MET A 1 272 ? 42.726 10.236  43.605 1.000 14.014 0 272 MET A C   1 ? 
ATOM   2122 O  O   . MET A 1 272 ? 42.364 11.221  42.930 1.000 16.936 0 272 MET A O   1 ? 
ATOM   2123 C  CB  . MET A 1 272 ? 45.139 9.772   43.935 1.000 14.971 0 272 MET A CB  1 ? 
ATOM   2124 C  CG  . MET A 1 272 ? 46.407 10.021  44.735 1.000 14.045 0 272 MET A CG  1 ? 
ATOM   2125 S  SD  . MET A 1 272 ? 46.750 11.745  45.108 1.000 16.734 0 272 MET A SD  1 ? 
ATOM   2126 C  CE  . MET A 1 272 ? 46.947 12.397  43.435 1.000 17.929 0 272 MET A CE  1 ? 
ATOM   2127 N  N   . VAL A 1 273 ? 42.090 9.073   43.474 1.000 14.715 0 273 VAL A N   1 ? 
ATOM   2128 C  CA  . VAL A 1 273 ? 40.976 8.944   42.554 1.000 15.081 0 273 VAL A CA  1 ? 
ATOM   2129 C  C   . VAL A 1 273 ? 39.802 9.779   43.050 1.000 16.051 0 273 VAL A C   1 ? 
ATOM   2130 O  O   . VAL A 1 273 ? 39.210 10.520  42.229 1.000 17.531 0 273 VAL A O   1 ? 
ATOM   2131 C  CB  . VAL A 1 273 ? 40.590 7.464   42.347 1.000 14.646 0 273 VAL A CB  1 ? 
ATOM   2132 C  CG1 . VAL A 1 273 ? 39.219 7.279   41.633 1.000 15.327 0 273 VAL A CG1 1 ? 
ATOM   2133 C  CG2 . VAL A 1 273 ? 41.684 6.731   41.601 1.000 17.381 0 273 VAL A CG2 1 ? 
ATOM   2134 N  N   . SER A 1 274 ? 39.462 9.682   44.326 1.000 16.967 0 274 SER A N   1 ? 
ATOM   2135 C  CA  . SER A 1 274 ? 38.248 10.291  44.838 1.000 17.791 0 274 SER A CA  1 ? 
ATOM   2136 C  C   . SER A 1 274 ? 38.366 11.819  44.931 1.000 18.818 0 274 SER A C   1 ? 
ATOM   2137 O  O   . SER A 1 274 ? 37.329 12.485  44.912 1.000 17.588 0 274 SER A O   1 ? 
ATOM   2138 C  CB  . SER A 1 274 ? 37.853 9.626   46.146 1.000 18.288 0 274 SER A CB  1 ? 
ATOM   2139 O  OG  . SER A 1 274 ? 38.706 9.975   47.225 1.000 20.223 0 274 SER A OG  1 ? 
ATOM   2140 N  N   . ARG A 1 275 ? 39.578 12.396  45.102 1.000 16.083 0 275 ARG A N   1 ? 
ATOM   2141 C  CA  . ARG A 1 275 ? 39.649 13.841  45.281 1.000 16.197 0 275 ARG A CA  1 ? 
ATOM   2142 C  C   . ARG A 1 275 ? 40.215 14.624  44.097 1.000 17.867 0 275 ARG A C   1 ? 
ATOM   2143 O  O   . ARG A 1 275 ? 40.231 15.851  44.132 1.000 16.980 0 275 ARG A O   1 ? 
ATOM   2144 C  CB  . ARG A 1 275 ? 40.524 14.086  46.508 1.000 18.733 0 275 ARG A CB  1 ? 
ATOM   2145 C  CG  . ARG A 1 275 ? 40.019 13.377  47.762 1.000 20.713 0 275 ARG A CG  1 ? 
ATOM   2146 C  CD  . ARG A 1 275 ? 38.624 13.664  48.177 1.000 22.923 0 275 ARG A CD  1 ? 
ATOM   2147 N  NE  . ARG A 1 275 ? 38.453 15.064  48.571 1.000 21.762 0 275 ARG A NE  1 ? 
ATOM   2148 C  CZ  . ARG A 1 275 ? 37.341 15.495  49.159 1.000 22.231 0 275 ARG A CZ  1 ? 
ATOM   2149 N  NH1 . ARG A 1 275 ? 36.285 14.732  49.259 1.000 24.245 0 275 ARG A NH1 1 ? 
ATOM   2150 N  NH2 . ARG A 1 275 ? 37.274 16.726  49.600 1.000 23.249 0 275 ARG A NH2 1 ? 
ATOM   2151 N  N   . ALA A 1 276 ? 40.703 13.948  43.043 1.000 18.783 0 276 ALA A N   1 ? 
ATOM   2152 C  CA  . ALA A 1 276 ? 41.317 14.602  41.900 1.000 17.882 0 276 ALA A CA  1 ? 
ATOM   2153 C  C   . ALA A 1 276 ? 40.398 15.674  41.309 1.000 18.571 0 276 ALA A C   1 ? 
ATOM   2154 O  O   . ALA A 1 276 ? 40.875 16.729  40.881 1.000 18.298 0 276 ALA A O   1 ? 
ATOM   2155 C  CB  . ALA A 1 276 ? 41.596 13.605  40.830 1.000 17.849 0 276 ALA A CB  1 ? 
ATOM   2156 N  N   . GLU A 1 277 ? 39.077 15.454  41.314 1.000 19.273 0 277 GLU A N   1 ? 
ATOM   2157 C  CA  . GLU A 1 277 ? 38.173 16.446  40.725 1.000 21.373 0 277 GLU A CA  1 ? 
ATOM   2158 C  C   . GLU A 1 277 ? 37.631 17.451  41.728 1.000 21.392 0 277 GLU A C   1 ? 
ATOM   2159 O  O   . GLU A 1 277 ? 36.975 18.417  41.330 1.000 23.142 0 277 GLU A O   1 ? 
ATOM   2160 C  CB  . GLU A 1 277 ? 36.952 15.851  40.033 1.000 23.947 0 277 GLU A CB  1 ? 
ATOM   2161 C  CG  . GLU A 1 277 ? 37.341 15.089  38.790 1.000 23.572 0 277 GLU A CG  1 ? 
ATOM   2162 C  CD  . GLU A 1 277 ? 36.140 14.366  38.171 1.000 25.134 0 277 GLU A CD  1 ? 
ATOM   2163 O  OE1 . GLU A 1 277 ? 35.004 14.852  38.211 1.000 28.021 0 277 GLU A OE1 1 ? 
ATOM   2164 O  OE2 . GLU A 1 277 ? 36.385 13.301  37.654 1.000 23.018 0 277 GLU A OE2 1 ? 
ATOM   2165 N  N   . ILE A 1 278 ? 37.866 17.257  43.019 1.000 18.922 0 278 ILE A N   1 ? 
ATOM   2166 C  CA  . ILE A 1 278 ? 37.264 18.085  44.052 1.000 21.342 0 278 ILE A CA  1 ? 
ATOM   2167 C  C   . ILE A 1 278 ? 38.213 19.141  44.576 1.000 21.103 0 278 ILE A C   1 ? 
ATOM   2168 O  O   . ILE A 1 278 ? 37.921 20.337  44.525 1.000 20.472 0 278 ILE A O   1 ? 
ATOM   2169 C  CB  . ILE A 1 278 ? 36.777 17.192  45.203 1.000 22.922 0 278 ILE A CB  1 ? 
ATOM   2170 C  CG1 . ILE A 1 278 ? 35.824 16.137  44.643 1.000 25.052 0 278 ILE A CG1 1 ? 
ATOM   2171 C  CG2 . ILE A 1 278 ? 36.123 18.010  46.312 1.000 26.142 0 278 ILE A CG2 1 ? 
ATOM   2172 C  CD1 . ILE A 1 278 ? 35.237 15.239  45.706 1.000 27.969 0 278 ILE A CD1 1 ? 
ATOM   2173 N  N   . ASP A 1 279 ? 39.340 18.709  45.150 1.000 19.131 0 279 ASP A N   1 ? 
ATOM   2174 C  CA  . ASP A 1 279 ? 40.141 19.629  45.919 1.000 20.029 0 279 ASP A CA  1 ? 
ATOM   2175 C  C   . ASP A 1 279 ? 41.605 19.246  45.883 1.000 18.127 0 279 ASP A C   1 ? 
ATOM   2176 O  O   . ASP A 1 279 ? 42.366 19.644  46.776 1.000 16.195 0 279 ASP A O   1 ? 
ATOM   2177 C  CB  . ASP A 1 279 ? 39.630 19.710  47.356 1.000 20.875 0 279 ASP A CB  1 ? 
ATOM   2178 C  CG  . ASP A 1 279 ? 39.656 18.421  48.158 1.000 23.467 0 279 ASP A CG  1 ? 
ATOM   2179 O  OD1 . ASP A 1 279 ? 39.834 17.342  47.527 1.000 21.886 0 279 ASP A OD1 1 ? 
ATOM   2180 O  OD2 . ASP A 1 279 ? 39.435 18.527  49.405 1.000 22.396 0 279 ASP A OD2 1 ? 
ATOM   2181 N  N   . MET A 1 280 ? 42.058 18.564  44.824 1.000 16.561 0 280 MET A N   1 ? 
ATOM   2182 C  CA  . MET A 1 280 ? 43.464 18.161  44.769 1.000 18.991 0 280 MET A CA  1 ? 
ATOM   2183 C  C   . MET A 1 280 ? 44.471 19.327  44.849 1.000 16.422 0 280 MET A C   1 ? 
ATOM   2184 O  O   . MET A 1 280 ? 45.544 19.186  45.429 1.000 18.093 0 280 MET A O   1 ? 
ATOM   2185 C  CB  . MET A 1 280 ? 43.685 17.316  43.506 1.000 18.725 0 280 MET A CB  1 ? 
ATOM   2186 C  CG  . MET A 1 280 ? 45.066 16.705  43.453 1.000 18.134 0 280 MET A CG  1 ? 
ATOM   2187 S  SD  . MET A 1 280 ? 45.467 15.617  44.824 1.000 19.586 0 280 MET A SD  1 ? 
ATOM   2188 C  CE  . MET A 1 280 ? 44.244 14.309  44.498 1.000 20.549 0 280 MET A CE  1 ? 
ATOM   2189 N  N   . LEU A 1 281 ? 44.155 20.497  44.284 1.000 18.632 0 281 LEU A N   1 ? 
ATOM   2190 C  CA  . LEU A 1 281 ? 45.043 21.650  44.353 1.000 18.284 0 281 LEU A CA  1 ? 
ATOM   2191 C  C   . LEU A 1 281 ? 45.162 22.165  45.779 1.000 17.607 0 281 LEU A C   1 ? 
ATOM   2192 O  O   . LEU A 1 281 ? 46.232 22.564  46.254 1.000 18.890 0 281 LEU A O   1 ? 
ATOM   2193 C  CB  . LEU A 1 281 ? 44.494 22.735  43.433 1.000 19.740 0 281 LEU A CB  1 ? 
ATOM   2194 C  CG  . LEU A 1 281 ? 44.552 22.458  41.932 1.000 21.565 0 281 LEU A CG  1 ? 
ATOM   2195 C  CD1 . LEU A 1 281 ? 44.029 23.722  41.192 1.000 22.708 0 281 LEU A CD1 1 ? 
ATOM   2196 C  CD2 . LEU A 1 281 ? 45.946 22.104  41.525 1.000 24.686 0 281 LEU A CD2 1 ? 
ATOM   2197 N  N   . ASP A 1 282 ? 44.030 22.080  46.504 1.000 18.078 0 282 ASP A N   1 ? 
ATOM   2198 C  CA  . ASP A 1 282 ? 44.046 22.450  47.909 1.000 18.231 0 282 ASP A CA  1 ? 
ATOM   2199 C  C   . ASP A 1 282 ? 44.801 21.429  48.743 1.000 16.213 0 282 ASP A C   1 ? 
ATOM   2200 O  O   . ASP A 1 282 ? 45.524 21.782  49.673 1.000 18.469 0 282 ASP A O   1 ? 
ATOM   2201 C  CB  . ASP A 1 282 ? 42.655 22.598  48.465 1.000 20.617 0 282 ASP A CB  1 ? 
ATOM   2202 C  CG  . ASP A 1 282 ? 41.829 23.599  47.679 1.000 26.364 0 282 ASP A CG  1 ? 
ATOM   2203 O  OD1 . ASP A 1 282 ? 42.128 24.801  47.790 1.000 26.218 0 282 ASP A OD1 1 ? 
ATOM   2204 O  OD2 . ASP A 1 282 ? 41.000 23.161  46.862 1.000 25.083 0 282 ASP A OD2 1 ? 
ATOM   2205 N  N   . ILE A 1 283 ? 44.592 20.163  48.469 1.000 16.256 0 283 ILE A N   1 ? 
ATOM   2206 C  CA  . ILE A 1 283 ? 45.350 19.123  49.110 1.000 15.710 0 283 ILE A CA  1 ? 
ATOM   2207 C  C   . ILE A 1 283 ? 46.861 19.370  48.926 1.000 16.980 0 283 ILE A C   1 ? 
ATOM   2208 O  O   . ILE A 1 283 ? 47.625 19.258  49.863 1.000 15.782 0 283 ILE A O   1 ? 
ATOM   2209 C  CB  . ILE A 1 283 ? 44.894 17.733  48.605 1.000 16.214 0 283 ILE A CB  1 ? 
ATOM   2210 C  CG1 . ILE A 1 283 ? 43.463 17.431  49.038 1.000 16.160 0 283 ILE A CG1 1 ? 
ATOM   2211 C  CG2 . ILE A 1 283 ? 45.884 16.667  49.074 1.000 16.716 0 283 ILE A CG2 1 ? 
ATOM   2212 C  CD1 . ILE A 1 283 ? 42.845 16.195  48.405 1.000 17.124 0 283 ILE A CD1 1 ? 
ATOM   2213 N  N   . ARG A 1 284 ? 47.305 19.650  47.704 1.000 18.419 0 284 ARG A N   1 ? 
ATOM   2214 C  CA  . ARG A 1 284 ? 48.706 19.878  47.402 1.000 18.698 0 284 ARG A CA  1 ? 
ATOM   2215 C  C   . ARG A 1 284 ? 49.254 21.030  48.223 1.000 17.369 0 284 ARG A C   1 ? 
ATOM   2216 O  O   . ARG A 1 284 ? 50.342 20.936  48.767 1.000 19.277 0 284 ARG A O   1 ? 
ATOM   2217 C  CB  . ARG A 1 284 ? 48.857 20.178  45.910 1.000 19.392 0 284 ARG A CB  1 ? 
ATOM   2218 C  CG  . ARG A 1 284 ? 48.885 18.920  45.084 1.000 20.005 0 284 ARG A CG  1 ? 
ATOM   2219 C  CD  . ARG A 1 284 ? 48.635 19.226  43.626 1.000 23.304 0 284 ARG A CD  1 ? 
ATOM   2220 N  NE  . ARG A 1 284 ? 49.666 20.125  43.100 1.000 27.902 0 284 ARG A NE  1 ? 
ATOM   2221 C  CZ  . ARG A 1 284 ? 49.694 20.662  41.868 1.000 27.137 0 284 ARG A CZ  1 ? 
ATOM   2222 N  NH1 . ARG A 1 284 ? 48.850 20.293  40.935 1.000 22.387 0 284 ARG A NH1 1 ? 
ATOM   2223 N  NH2 . ARG A 1 284 ? 50.606 21.559  41.563 1.000 35.482 0 284 ARG A NH2 1 ? 
ATOM   2224 N  N   . ALA A 1 285 ? 48.488 22.124  48.282 1.000 17.639 0 285 ALA A N   1 ? 
ATOM   2225 C  CA  . ALA A 1 285 ? 48.882 23.295  49.036 1.000 19.582 0 285 ALA A CA  1 ? 
ATOM   2226 C  C   . ALA A 1 285 ? 49.028 22.957  50.507 1.000 20.810 0 285 ALA A C   1 ? 
ATOM   2227 O  O   . ALA A 1 285 ? 50.010 23.330  51.141 1.000 20.810 0 285 ALA A O   1 ? 
ATOM   2228 C  CB  . ALA A 1 285 ? 47.896 24.407  48.825 1.000 20.510 0 285 ALA A CB  1 ? 
ATOM   2229 N  N   . HIS A 1 286 ? 48.042 22.244  51.084 1.000 18.086 0 286 HIS A N   1 ? 
ATOM   2230 C  CA  . HIS A 1 286 ? 48.135 21.911  52.490 1.000 16.819 0 286 HIS A CA  1 ? 
ATOM   2231 C  C   . HIS A 1 286 ? 49.245 20.910  52.750 1.000 17.041 0 286 HIS A C   1 ? 
ATOM   2232 O  O   . HIS A 1 286 ? 49.945 20.958  53.781 1.000 17.634 0 286 HIS A O   1 ? 
ATOM   2233 C  CB  . HIS A 1 286 ? 46.806 21.368  53.056 1.000 17.493 0 286 HIS A CB  1 ? 
ATOM   2234 C  CG  . HIS A 1 286 ? 45.750 22.377  53.277 1.000 21.833 0 286 HIS A CG  1 ? 
ATOM   2235 N  ND1 . HIS A 1 286 ? 45.669 23.187  54.391 1.000 24.848 0 286 HIS A ND1 1 ? 
ATOM   2236 C  CD2 . HIS A 1 286 ? 44.789 22.783  52.448 1.000 22.436 0 286 HIS A CD2 1 ? 
ATOM   2237 C  CE1 . HIS A 1 286 ? 44.653 24.031  54.230 1.000 23.935 0 286 HIS A CE1 1 ? 
ATOM   2238 N  NE2 . HIS A 1 286 ? 44.091 23.785  53.047 1.000 23.800 0 286 HIS A NE2 1 ? 
ATOM   2239 N  N   . PHE A 1 287 ? 49.478 20.002  51.797 1.000 17.157 0 287 PHE A N   1 ? 
ATOM   2240 C  CA  . PHE A 1 287 ? 50.545 19.021  51.951 1.000 17.141 0 287 PHE A CA  1 ? 
ATOM   2241 C  C   . PHE A 1 287 ? 51.897 19.725  52.112 1.000 17.141 0 287 PHE A C   1 ? 
ATOM   2242 O  O   . PHE A 1 287 ? 52.688 19.392  52.984 1.000 17.331 0 287 PHE A O   1 ? 
ATOM   2243 C  CB  . PHE A 1 287 ? 50.534 18.074  50.745 1.000 17.035 0 287 PHE A CB  1 ? 
ATOM   2244 C  CG  . PHE A 1 287 ? 51.415 16.848  50.919 1.000 15.006 0 287 PHE A CG  1 ? 
ATOM   2245 C  CD1 . PHE A 1 287 ? 52.794 16.950  50.661 1.000 16.081 0 287 PHE A CD1 1 ? 
ATOM   2246 C  CD2 . PHE A 1 287 ? 50.934 15.611  51.319 1.000 14.092 0 287 PHE A CD2 1 ? 
ATOM   2247 C  CE1 . PHE A 1 287 ? 53.640 15.888  50.816 1.000 17.168 0 287 PHE A CE1 1 ? 
ATOM   2248 C  CE2 . PHE A 1 287 ? 51.813 14.539  51.517 1.000 15.471 0 287 PHE A CE2 1 ? 
ATOM   2249 C  CZ  . PHE A 1 287 ? 53.151 14.669  51.191 1.000 16.936 0 287 PHE A CZ  1 ? 
ATOM   2250 N  N   . LYS A 1 288 ? 52.176 20.625  51.188 1.000 19.043 0 288 LYS A N   1 ? 
ATOM   2251 C  CA  . LYS A 1 288 ? 53.398 21.423  51.184 1.000 21.746 0 288 LYS A CA  1 ? 
ATOM   2252 C  C   . LYS A 1 288 ? 53.563 22.216  52.481 1.000 21.399 0 288 LYS A C   1 ? 
ATOM   2253 O  O   . LYS A 1 288 ? 54.615 22.144  53.121 1.000 21.829 0 288 LYS A O   1 ? 
ATOM   2254 C  CB  . LYS A 1 288 ? 53.334 22.391  50.007 1.000 22.439 0 288 LYS A CB  1 ? 
ATOM   2255 C  CG  . LYS A 1 288 ? 54.567 23.279  49.865 1.000 26.300 0 288 LYS A CG  1 ? 
ATOM   2256 C  CD  . LYS A 1 288 ? 55.865 22.505  49.984 1.000 29.754 0 288 LYS A CD  1 ? 
ATOM   2257 C  CE  . LYS A 1 288 ? 56.801 22.821  48.861 1.000 36.521 0 288 LYS A CE  1 ? 
ATOM   2258 N  NZ  . LYS A 1 288 ? 57.126 24.249  48.872 1.000 37.780 0 288 LYS A NZ  1 ? 
ATOM   2259 N  N   . ARG A 1 289 ? 52.461 22.793  52.989 1.000 20.125 0 289 ARG A N   1 ? 
ATOM   2260 C  CA  . ARG A 1 289 ? 52.525 23.533  54.250 1.000 24.329 0 289 ARG A CA  1 ? 
ATOM   2261 C  C   . ARG A 1 289 ? 52.860 22.620  55.422 1.000 21.389 0 289 ARG A C   1 ? 
ATOM   2262 O  O   . ARG A 1 289 ? 53.620 22.997  56.303 1.000 21.745 0 289 ARG A O   1 ? 
ATOM   2263 C  CB  . ARG A 1 289 ? 51.207 24.313  54.418 1.000 28.102 0 289 ARG A CB  1 ? 
ATOM   2264 C  CG  . ARG A 1 289 ? 50.931 24.997  55.743 1.000 40.239 0 289 ARG A CG  1 ? 
ATOM   2265 C  CD  . ARG A 1 289 ? 49.463 25.534  55.725 1.000 52.839 0 289 ARG A CD  1 ? 
ATOM   2266 N  NE  . ARG A 1 289 ? 48.409 24.500  55.751 1.000 56.241 0 289 ARG A NE  1 ? 
ATOM   2267 C  CZ  . ARG A 1 289 ? 48.160 23.665  56.769 1.000 50.012 0 289 ARG A CZ  1 ? 
ATOM   2268 N  NH1 . ARG A 1 289 ? 48.816 23.836  57.911 1.000 44.126 0 289 ARG A NH1 1 ? 
ATOM   2269 N  NH2 . ARG A 1 289 ? 47.269 22.681  56.654 1.000 38.918 0 289 ARG A NH2 1 ? 
ATOM   2270 N  N   . LEU A 1 290 ? 52.198 21.462  55.513 1.000 19.824 0 290 LEU A N   1 ? 
ATOM   2271 C  CA  . LEU A 1 290 ? 52.349 20.563  56.634 1.000 20.724 0 290 LEU A CA  1 ? 
ATOM   2272 C  C   . LEU A 1 290 ? 53.714 19.894  56.624 1.000 22.973 0 290 LEU A C   1 ? 
ATOM   2273 O  O   . LEU A 1 290 ? 54.276 19.659  57.689 1.000 21.505 0 290 LEU A O   1 ? 
ATOM   2274 C  CB  . LEU A 1 290 ? 51.239 19.515  56.619 1.000 20.104 0 290 LEU A CB  1 ? 
ATOM   2275 C  CG  . LEU A 1 290 ? 49.819 20.009  56.940 1.000 23.088 0 290 LEU A CG  1 ? 
ATOM   2276 C  CD1 . LEU A 1 290 ? 48.816 18.953  56.539 1.000 24.565 0 290 LEU A CD1 1 ? 
ATOM   2277 C  CD2 . LEU A 1 290 ? 49.723 20.277  58.444 1.000 25.563 0 290 LEU A CD2 1 ? 
ATOM   2278 N  N   . TYR A 1 291 ? 54.232 19.545  55.432 1.000 20.026 0 291 TYR A N   1 ? 
ATOM   2279 C  CA  . TYR A 1 291 ? 55.268 18.539  55.320 1.000 18.633 0 291 TYR A CA  1 ? 
ATOM   2280 C  C   . TYR A 1 291 ? 56.552 19.058  54.651 1.000 18.121 0 291 TYR A C   1 ? 
ATOM   2281 O  O   . TYR A 1 291 ? 57.559 18.388  54.748 1.000 20.584 0 291 TYR A O   1 ? 
ATOM   2282 C  CB  . TYR A 1 291 ? 54.770 17.281  54.606 1.000 17.971 0 291 TYR A CB  1 ? 
ATOM   2283 C  CG  . TYR A 1 291 ? 53.588 16.671  55.345 1.000 18.283 0 291 TYR A CG  1 ? 
ATOM   2284 C  CD1 . TYR A 1 291 ? 53.712 16.264  56.678 1.000 19.170 0 291 TYR A CD1 1 ? 
ATOM   2285 C  CD2 . TYR A 1 291 ? 52.334 16.587  54.734 1.000 18.788 0 291 TYR A CD2 1 ? 
ATOM   2286 C  CE1 . TYR A 1 291 ? 52.624 15.785  57.384 1.000 20.195 0 291 TYR A CE1 1 ? 
ATOM   2287 C  CE2 . TYR A 1 291 ? 51.248 16.078  55.442 1.000 18.930 0 291 TYR A CE2 1 ? 
ATOM   2288 C  CZ  . TYR A 1 291 ? 51.401 15.659  56.751 1.000 20.837 0 291 TYR A CZ  1 ? 
ATOM   2289 O  OH  . TYR A 1 291 ? 50.279 15.172  57.415 1.000 23.513 0 291 TYR A OH  1 ? 
ATOM   2290 N  N   . GLY A 1 292 ? 56.494 20.255  54.074 1.000 18.670 0 292 GLY A N   1 ? 
ATOM   2291 C  CA  . GLY A 1 292 ? 57.629 20.956  53.491 1.000 21.404 0 292 GLY A CA  1 ? 
ATOM   2292 C  C   . GLY A 1 292 ? 58.192 20.246  52.281 1.000 21.746 0 292 GLY A C   1 ? 
ATOM   2293 O  O   . GLY A 1 292 ? 59.359 20.447  51.953 1.000 21.719 0 292 GLY A O   1 ? 
ATOM   2294 N  N   . LYS A 1 293 ? 57.375 19.401  51.613 1.000 21.255 0 293 LYS A N   1 ? 
ATOM   2295 C  CA  . LYS A 1 293 ? 57.732 18.709  50.382 1.000 20.166 0 293 LYS A CA  1 ? 
ATOM   2296 C  C   . LYS A 1 293 ? 56.480 18.726  49.511 1.000 20.066 0 293 LYS A C   1 ? 
ATOM   2297 O  O   . LYS A 1 293 ? 55.389 18.854  50.058 1.000 18.663 0 293 LYS A O   1 ? 
ATOM   2298 C  CB  . LYS A 1 293 ? 58.085 17.247  50.650 1.000 19.732 0 293 LYS A CB  1 ? 
ATOM   2299 C  CG  . LYS A 1 293 ? 59.178 17.038  51.703 1.000 19.978 0 293 LYS A CG  1 ? 
ATOM   2300 C  CD  . LYS A 1 293 ? 60.529 17.549  51.225 1.000 21.075 0 293 LYS A CD  1 ? 
ATOM   2301 C  CE  . LYS A 1 293 ? 61.724 17.209  52.093 1.000 27.764 0 293 LYS A CE  1 ? 
ATOM   2302 N  NZ  . LYS A 1 293 ? 62.032 15.811  51.860 1.000 37.175 0 293 LYS A NZ  1 ? 
ATOM   2303 N  N   . SER A 1 294 ? 56.616 18.633  48.189 1.000 16.594 0 294 SER A N   1 ? 
ATOM   2304 C  CA  . SER A 1 294 ? 55.464 18.537  47.326 1.000 17.452 0 294 SER A CA  1 ? 
ATOM   2305 C  C   . SER A 1 294 ? 54.877 17.137  47.425 1.000 16.295 0 294 SER A C   1 ? 
ATOM   2306 O  O   . SER A 1 294 ? 55.581 16.118  47.601 1.000 16.752 0 294 SER A O   1 ? 
ATOM   2307 C  CB  . SER A 1 294 ? 55.858 18.882  45.924 1.000 19.026 0 294 SER A CB  1 ? 
ATOM   2308 O  OG  . SER A 1 294 ? 56.711 17.891  45.371 1.000 17.843 0 294 SER A OG  1 ? 
ATOM   2309 N  N   . LEU A 1 295 ? 53.539 17.103  47.268 1.000 16.831 0 295 LEU A N   1 ? 
ATOM   2310 C  CA  . LEU A 1 295 ? 52.846 15.835  47.122 1.000 15.324 0 295 LEU A CA  1 ? 
ATOM   2311 C  C   . LEU A 1 295 ? 53.408 15.083  45.911 1.000 15.791 0 295 LEU A C   1 ? 
ATOM   2312 O  O   . LEU A 1 295 ? 53.612 13.879  45.965 1.000 17.021 0 295 LEU A O   1 ? 
ATOM   2313 C  CB  . LEU A 1 295 ? 51.331 16.040  46.976 1.000 14.603 0 295 LEU A CB  1 ? 
ATOM   2314 C  CG  . LEU A 1 295 ? 50.501 14.794  46.651 1.000 14.130 0 295 LEU A CG  1 ? 
ATOM   2315 C  CD1 . LEU A 1 295 ? 50.642 13.773  47.733 1.000 15.870 0 295 LEU A CD1 1 ? 
ATOM   2316 C  CD2 . LEU A 1 295 ? 49.038 15.167  46.517 1.000 16.840 0 295 LEU A CD2 1 ? 
ATOM   2317 N  N   . TYR A 1 296 ? 53.557 15.797  44.791 1.000 17.319 0 296 TYR A N   1 ? 
ATOM   2318 C  CA  . TYR A 1 296 ? 54.125 15.234  43.583 1.000 19.108 0 296 TYR A CA  1 ? 
ATOM   2319 C  C   . TYR A 1 296 ? 55.377 14.416  43.864 1.000 18.077 0 296 TYR A C   1 ? 
ATOM   2320 O  O   . TYR A 1 296 ? 55.490 13.263  43.434 1.000 16.497 0 296 TYR A O   1 ? 
ATOM   2321 C  CB  . TYR A 1 296 ? 54.514 16.382  42.657 1.000 23.069 0 296 TYR A CB  1 ? 
ATOM   2322 C  CG  . TYR A 1 296 ? 54.994 15.897  41.297 1.000 23.865 0 296 TYR A CG  1 ? 
ATOM   2323 C  CD1 . TYR A 1 296 ? 56.311 15.570  41.064 1.000 30.826 0 296 TYR A CD1 1 ? 
ATOM   2324 C  CD2 . TYR A 1 296 ? 54.096 15.814  40.250 1.000 24.219 0 296 TYR A CD2 1 ? 
ATOM   2325 C  CE1 . TYR A 1 296 ? 56.723 15.141  39.806 1.000 29.566 0 296 TYR A CE1 1 ? 
ATOM   2326 C  CE2 . TYR A 1 296 ? 54.496 15.407  38.991 1.000 28.261 0 296 TYR A CE2 1 ? 
ATOM   2327 C  CZ  . TYR A 1 296 ? 55.808 15.082  38.773 1.000 32.246 0 296 TYR A CZ  1 ? 
ATOM   2328 O  OH  . TYR A 1 296 ? 56.102 14.674  37.501 1.000 37.218 0 296 TYR A OH  1 ? 
ATOM   2329 N  N   . SER A 1 297 ? 56.317 14.994  44.635 1.000 17.947 0 297 SER A N   1 ? 
ATOM   2330 C  CA  . SER A 1 297 ? 57.608 14.365  44.948 1.000 17.390 0 297 SER A CA  1 ? 
ATOM   2331 C  C   . SER A 1 297 ? 57.458 13.093  45.788 1.000 17.173 0 297 SER A C   1 ? 
ATOM   2332 O  O   . SER A 1 297 ? 58.234 12.160  45.665 1.000 17.665 0 297 SER A O   1 ? 
ATOM   2333 C  CB  . SER A 1 297 ? 58.509 15.350  45.658 1.000 19.099 0 297 SER A CB  1 ? 
ATOM   2334 O  OG  . SER A 1 297 ? 58.111 15.539  47.005 1.000 19.388 0 297 SER A OG  1 ? 
ATOM   2335 N  N   . PHE A 1 298 ? 56.419 13.064  46.675 1.000 15.766 0 298 PHE A N   1 ? 
ATOM   2336 C  CA  . PHE A 1 298 ? 56.144 11.897  47.483 1.000 15.092 0 298 PHE A CA  1 ? 
ATOM   2337 C  C   . PHE A 1 298 ? 55.676 10.750  46.600 1.000 15.256 0 298 PHE A C   1 ? 
ATOM   2338 O  O   . PHE A 1 298 ? 56.154 9.622   46.706 1.000 17.427 0 298 PHE A O   1 ? 
ATOM   2339 C  CB  . PHE A 1 298 ? 55.060 12.154  48.561 1.000 17.449 0 298 PHE A CB  1 ? 
ATOM   2340 C  CG  . PHE A 1 298 ? 55.661 12.379  49.935 1.000 17.706 0 298 PHE A CG  1 ? 
ATOM   2341 C  CD1 . PHE A 1 298 ? 56.480 13.468  50.155 1.000 16.646 0 298 PHE A CD1 1 ? 
ATOM   2342 C  CD2 . PHE A 1 298 ? 55.272 11.625  51.039 1.000 19.020 0 298 PHE A CD2 1 ? 
ATOM   2343 C  CE1 . PHE A 1 298 ? 57.083 13.685  51.376 1.000 19.489 0 298 PHE A CE1 1 ? 
ATOM   2344 C  CE2 . PHE A 1 298 ? 55.830 11.894  52.281 1.000 19.605 0 298 PHE A CE2 1 ? 
ATOM   2345 C  CZ  . PHE A 1 298 ? 56.735 12.924  52.444 1.000 19.907 0 298 PHE A CZ  1 ? 
ATOM   2346 N  N   . ILE A 1 299 ? 54.720 11.059  45.713 1.000 14.989 0 299 ILE A N   1 ? 
ATOM   2347 C  CA  . ILE A 1 299 ? 54.222 10.022  44.824 1.000 14.547 0 299 ILE A CA  1 ? 
ATOM   2348 C  C   . ILE A 1 299 ? 55.360 9.566   43.899 1.000 15.935 0 299 ILE A C   1 ? 
ATOM   2349 O  O   . ILE A 1 299 ? 55.535 8.371   43.638 1.000 16.954 0 299 ILE A O   1 ? 
ATOM   2350 C  CB  . ILE A 1 299 ? 53.047 10.582  43.994 1.000 15.698 0 299 ILE A CB  1 ? 
ATOM   2351 C  CG1 . ILE A 1 299 ? 51.828 10.974  44.873 1.000 16.584 0 299 ILE A CG1 1 ? 
ATOM   2352 C  CG2 . ILE A 1 299 ? 52.650 9.632   42.876 1.000 16.811 0 299 ILE A CG2 1 ? 
ATOM   2353 C  CD1 . ILE A 1 299 ? 50.726 11.709  44.119 1.000 16.963 0 299 ILE A CD1 1 ? 
ATOM   2354 N  N   . LYS A 1 300 ? 56.119 10.510  43.391 1.000 17.287 0 300 LYS A N   1 ? 
ATOM   2355 C  CA  . LYS A 1 300 ? 57.215 10.157  42.488 1.000 18.458 0 300 LYS A CA  1 ? 
ATOM   2356 C  C   . LYS A 1 300 ? 58.206 9.227   43.185 1.000 21.131 0 300 LYS A C   1 ? 
ATOM   2357 O  O   . LYS A 1 300 ? 58.692 8.266   42.587 1.000 23.214 0 300 LYS A O   1 ? 
ATOM   2358 C  CB  . LYS A 1 300 ? 57.830 11.428  41.885 1.000 22.154 0 300 LYS A CB  1 ? 
ATOM   2359 C  CG  . LYS A 1 300 ? 58.909 11.069  40.854 1.000 28.515 0 300 LYS A CG  1 ? 
ATOM   2360 C  CD  . LYS A 1 300 ? 59.550 12.315  40.267 1.000 33.990 0 300 LYS A CD  1 ? 
ATOM   2361 C  CE  . LYS A 1 300 ? 60.469 13.008  41.253 1.000 38.504 0 300 LYS A CE  1 ? 
ATOM   2362 N  NZ  . LYS A 1 300 ? 61.611 13.656  40.594 1.000 41.486 0 300 LYS A NZ  1 ? 
ATOM   2363 N  N   . GLY A 1 301 ? 58.461 9.466   44.465 1.000 22.497 0 301 GLY A N   1 ? 
ATOM   2364 C  CA  . GLY A 1 301 ? 59.427 8.729   45.236 1.000 23.252 0 301 GLY A CA  1 ? 
ATOM   2365 C  C   . GLY A 1 301 ? 58.934 7.370   45.720 1.000 26.053 0 301 GLY A C   1 ? 
ATOM   2366 O  O   . GLY A 1 301 ? 59.751 6.536   46.072 1.000 26.472 0 301 GLY A O   1 ? 
ATOM   2367 N  N   . ASP A 1 302 ? 57.609 7.140   45.802 1.000 20.083 0 302 ASP A N   1 ? 
ATOM   2368 C  CA  . ASP A 1 302 ? 57.086 5.934   46.422 1.000 21.642 0 302 ASP A CA  1 ? 
ATOM   2369 C  C   . ASP A 1 302 ? 56.416 4.982   45.454 1.000 21.632 0 302 ASP A C   1 ? 
ATOM   2370 O  O   . ASP A 1 302 ? 55.984 3.907   45.862 1.000 24.727 0 302 ASP A O   1 ? 
ATOM   2371 C  CB  . ASP A 1 302 ? 56.073 6.225   47.528 1.000 23.972 0 302 ASP A CB  1 ? 
ATOM   2372 C  CG  . ASP A 1 302 ? 56.469 5.788   48.931 1.000 26.756 0 302 ASP A CG  1 ? 
ATOM   2373 O  OD1 . ASP A 1 302 ? 57.594 6.056   49.317 1.000 34.419 0 302 ASP A OD1 1 ? 
ATOM   2374 O  OD2 . ASP A 1 302 ? 55.613 5.193   49.625 1.000 34.535 0 302 ASP A OD2 1 ? 
ATOM   2375 N  N   . THR A 1 303 ? 56.312 5.340   44.172 1.000 20.307 0 303 THR A N   1 ? 
ATOM   2376 C  CA  . THR A 1 303 ? 55.632 4.511   43.213 1.000 18.982 0 303 THR A CA  1 ? 
ATOM   2377 C  C   . THR A 1 303 ? 56.507 4.445   41.958 1.000 18.997 0 303 THR A C   1 ? 
ATOM   2378 O  O   . THR A 1 303 ? 57.390 5.266   41.774 1.000 22.034 0 303 THR A O   1 ? 
ATOM   2379 C  CB  . THR A 1 303 ? 54.212 5.034   42.896 1.000 19.560 0 303 THR A CB  1 ? 
ATOM   2380 O  OG1 . THR A 1 303 ? 54.296 6.316   42.277 1.000 20.465 0 303 THR A OG1 1 ? 
ATOM   2381 C  CG2 . THR A 1 303 ? 53.347 5.103   44.145 1.000 19.951 0 303 THR A CG2 1 ? 
ATOM   2382 N  N   . SER A 1 304 ? 56.135 3.541   41.044 1.000 20.700 0 304 SER A N   1 ? 
ATOM   2383 C  CA  . SER A 1 304 ? 56.855 3.499   39.775 1.000 21.855 0 304 SER A CA  1 ? 
ATOM   2384 C  C   . SER A 1 304 ? 55.937 3.024   38.658 1.000 18.732 0 304 SER A C   1 ? 
ATOM   2385 O  O   . SER A 1 304 ? 54.766 2.706   38.862 1.000 20.186 0 304 SER A O   1 ? 
ATOM   2386 C  CB  . SER A 1 304 ? 58.088 2.619   39.926 1.000 30.354 0 304 SER A CB  1 ? 
ATOM   2387 O  OG  . SER A 1 304 ? 57.663 1.280   40.051 1.000 33.511 0 304 SER A OG  1 ? 
ATOM   2388 N  N   . GLY A 1 305 ? 56.481 3.025   37.440 1.000 17.907 0 305 GLY A N   1 ? 
ATOM   2389 C  CA  . GLY A 1 305 ? 55.764 2.482   36.302 1.000 19.018 0 305 GLY A CA  1 ? 
ATOM   2390 C  C   . GLY A 1 305 ? 54.522 3.290   35.878 1.000 19.423 0 305 GLY A C   1 ? 
ATOM   2391 O  O   . GLY A 1 305 ? 54.427 4.491   36.102 1.000 18.834 0 305 GLY A O   1 ? 
ATOM   2392 N  N   . ASP A 1 306 ? 53.586 2.625   35.206 1.000 18.629 0 306 ASP A N   1 ? 
ATOM   2393 C  CA  . ASP A 1 306 ? 52.345 3.236   34.751 1.000 17.636 0 306 ASP A CA  1 ? 
ATOM   2394 C  C   . ASP A 1 306 ? 51.490 3.676   35.946 1.000 17.566 0 306 ASP A C   1 ? 
ATOM   2395 O  O   . ASP A 1 306 ? 50.788 4.674   35.858 1.000 18.839 0 306 ASP A O   1 ? 
ATOM   2396 C  CB  . ASP A 1 306 ? 51.551 2.336   33.820 1.000 19.268 0 306 ASP A CB  1 ? 
ATOM   2397 C  CG  . ASP A 1 306 ? 52.299 1.988   32.542 1.000 23.061 0 306 ASP A CG  1 ? 
ATOM   2398 O  OD1 . ASP A 1 306 ? 52.836 2.915   31.978 1.000 27.236 0 306 ASP A OD1 1 ? 
ATOM   2399 O  OD2 . ASP A 1 306 ? 52.342 0.778   32.228 1.000 25.127 0 306 ASP A OD2 1 ? 
ATOM   2400 N  N   . TYR A 1 307 ? 51.617 2.968   37.054 1.000 17.897 0 307 TYR A N   1 ? 
ATOM   2401 C  CA  . TYR A 1 307 ? 50.945 3.346   38.298 1.000 14.601 0 307 TYR A CA  1 ? 
ATOM   2402 C  C   . TYR A 1 307 ? 51.390 4.755   38.705 1.000 15.980 0 307 TYR A C   1 ? 
ATOM   2403 O  O   . TYR A 1 307 ? 50.558 5.633   38.942 1.000 14.299 0 307 TYR A O   1 ? 
ATOM   2404 C  CB  . TYR A 1 307 ? 51.322 2.302   39.353 1.000 16.488 0 307 TYR A CB  1 ? 
ATOM   2405 C  CG  . TYR A 1 307 ? 50.807 2.515   40.767 1.000 15.278 0 307 TYR A CG  1 ? 
ATOM   2406 C  CD1 . TYR A 1 307 ? 49.536 3.007   41.032 1.000 17.088 0 307 TYR A CD1 1 ? 
ATOM   2407 C  CD2 . TYR A 1 307 ? 51.624 2.224   41.838 1.000 17.484 0 307 TYR A CD2 1 ? 
ATOM   2408 C  CE1 . TYR A 1 307 ? 49.066 3.110   42.328 1.000 15.484 0 307 TYR A CE1 1 ? 
ATOM   2409 C  CE2 . TYR A 1 307 ? 51.183 2.380   43.144 1.000 18.530 0 307 TYR A CE2 1 ? 
ATOM   2410 C  CZ  . TYR A 1 307 ? 49.890 2.780   43.388 1.000 17.671 0 307 TYR A CZ  1 ? 
ATOM   2411 O  OH  . TYR A 1 307 ? 49.393 2.966   44.646 1.000 17.910 0 307 TYR A OH  1 ? 
ATOM   2412 N  N   . ARG A 1 308 ? 52.725 4.967   38.839 1.000 16.530 0 308 ARG A N   1 ? 
ATOM   2413 C  CA  . ARG A 1 308 ? 53.251 6.305   39.061 1.000 14.540 0 308 ARG A CA  1 ? 
ATOM   2414 C  C   . ARG A 1 308 ? 52.716 7.317   38.050 1.000 14.008 0 308 ARG A C   1 ? 
ATOM   2415 O  O   . ARG A 1 308 ? 52.247 8.407   38.440 1.000 16.477 0 308 ARG A O   1 ? 
ATOM   2416 C  CB  . ARG A 1 308 ? 54.799 6.332   39.099 1.000 15.435 0 308 ARG A CB  1 ? 
ATOM   2417 C  CG  . ARG A 1 308 ? 55.335 7.743   39.124 1.000 15.236 0 308 ARG A CG  1 ? 
ATOM   2418 C  CD  . ARG A 1 308 ? 56.776 7.658   39.664 1.000 16.939 0 308 ARG A CD  1 ? 
ATOM   2419 N  NE  . ARG A 1 308 ? 57.630 6.927   38.728 1.000 19.810 0 308 ARG A NE  1 ? 
ATOM   2420 C  CZ  . ARG A 1 308 ? 58.957 6.828   38.906 1.000 24.946 0 308 ARG A CZ  1 ? 
ATOM   2421 N  NH1 . ARG A 1 308 ? 59.512 7.319   39.989 1.000 19.999 0 308 ARG A NH1 1 ? 
ATOM   2422 N  NH2 . ARG A 1 308 ? 59.716 6.218   37.986 1.000 27.346 0 308 ARG A NH2 1 ? 
ATOM   2423 N  N   . LYS A 1 309 ? 52.818 6.997   36.756 1.000 14.964 0 309 LYS A N   1 ? 
ATOM   2424 C  CA  . LYS A 1 309 ? 52.452 7.969   35.744 1.000 16.502 0 309 LYS A CA  1 ? 
ATOM   2425 C  C   . LYS A 1 309 ? 51.046 8.493   35.968 1.000 17.870 0 309 LYS A C   1 ? 
ATOM   2426 O  O   . LYS A 1 309 ? 50.811 9.714   35.873 1.000 17.037 0 309 LYS A O   1 ? 
ATOM   2427 C  CB  . LYS A 1 309 ? 52.599 7.283   34.394 1.000 17.775 0 309 LYS A CB  1 ? 
ATOM   2428 C  CG  . LYS A 1 309 ? 54.027 7.182   33.952 1.000 21.422 0 309 LYS A CG  1 ? 
ATOM   2429 C  CD  . LYS A 1 309 ? 54.192 6.348   32.682 1.000 27.775 0 309 LYS A CD  1 ? 
ATOM   2430 C  CE  . LYS A 1 309 ? 55.637 6.343   32.250 1.000 29.694 0 309 LYS A CE  1 ? 
ATOM   2431 N  NZ  . LYS A 1 309 ? 55.759 5.797   30.898 1.000 35.175 0 309 LYS A NZ  1 ? 
ATOM   2432 N  N   . VAL A 1 310 ? 50.090 7.571   36.185 1.000 16.196 0 310 VAL A N   1 ? 
ATOM   2433 C  CA  . VAL A 1 310 ? 48.701 7.995   36.283 1.000 14.633 0 310 VAL A CA  1 ? 
ATOM   2434 C  C   . VAL A 1 310 ? 48.485 8.783   37.589 1.000 15.035 0 310 VAL A C   1 ? 
ATOM   2435 O  O   . VAL A 1 310 ? 47.823 9.805   37.605 1.000 14.695 0 310 VAL A O   1 ? 
ATOM   2436 C  CB  . VAL A 1 310 ? 47.679 6.877   36.036 1.000 15.940 0 310 VAL A CB  1 ? 
ATOM   2437 C  CG1 . VAL A 1 310 ? 47.809 5.817   37.111 1.000 16.957 0 310 VAL A CG1 1 ? 
ATOM   2438 C  CG2 . VAL A 1 310 ? 46.289 7.521   35.851 1.000 16.551 0 310 VAL A CG2 1 ? 
ATOM   2439 N  N   . LEU A 1 311 ? 49.116 8.382   38.691 1.000 14.083 0 311 LEU A N   1 ? 
ATOM   2440 C  CA  . LEU A 1 311 ? 48.968 9.116   39.924 1.000 15.635 0 311 LEU A CA  1 ? 
ATOM   2441 C  C   . LEU A 1 311 ? 49.528 10.518  39.813 1.000 14.700 0 311 LEU A C   1 ? 
ATOM   2442 O  O   . LEU A 1 311 ? 48.940 11.469  40.349 1.000 16.757 0 311 LEU A O   1 ? 
ATOM   2443 C  CB  . LEU A 1 311 ? 49.665 8.408   41.066 1.000 14.973 0 311 LEU A CB  1 ? 
ATOM   2444 C  CG  . LEU A 1 311 ? 49.029 7.107   41.530 1.000 15.426 0 311 LEU A CG  1 ? 
ATOM   2445 C  CD1 . LEU A 1 311 ? 49.809 6.658   42.724 1.000 17.588 0 311 LEU A CD1 1 ? 
ATOM   2446 C  CD2 . LEU A 1 311 ? 47.555 7.210   41.900 1.000 16.204 0 311 LEU A CD2 1 ? 
ATOM   2447 N  N   . LEU A 1 312 ? 50.600 10.651  39.008 1.000 14.116 0 312 LEU A N   1 ? 
ATOM   2448 C  CA  . LEU A 1 312 ? 51.152 11.999  38.874 1.000 13.995 0 312 LEU A CA  1 ? 
ATOM   2449 C  C   . LEU A 1 312 ? 50.266 12.871  38.015 1.000 15.937 0 312 LEU A C   1 ? 
ATOM   2450 O  O   . LEU A 1 312 ? 50.270 14.085  38.223 1.000 18.135 0 312 LEU A O   1 ? 
ATOM   2451 C  CB  . LEU A 1 312 ? 52.573 11.911  38.319 1.000 15.149 0 312 LEU A CB  1 ? 
ATOM   2452 C  CG  . LEU A 1 312 ? 53.602 11.283  39.251 1.000 16.298 0 312 LEU A CG  1 ? 
ATOM   2453 C  CD1 . LEU A 1 312 ? 54.962 11.240  38.541 1.000 18.983 0 312 LEU A CD1 1 ? 
ATOM   2454 C  CD2 . LEU A 1 312 ? 53.725 12.008  40.592 1.000 17.040 0 312 LEU A CD2 1 ? 
ATOM   2455 N  N   . VAL A 1 313 ? 49.526 12.313  37.067 1.000 16.863 0 313 VAL A N   1 ? 
ATOM   2456 C  CA  . VAL A 1 313 ? 48.588 13.121  36.310 1.000 17.135 0 313 VAL A CA  1 ? 
ATOM   2457 C  C   . VAL A 1 313 ? 47.432 13.549  37.228 1.000 17.624 0 313 VAL A C   1 ? 
ATOM   2458 O  O   . VAL A 1 313 ? 46.987 14.716  37.195 1.000 18.956 0 313 VAL A O   1 ? 
ATOM   2459 C  CB  . VAL A 1 313 ? 48.067 12.436  35.031 1.000 17.642 0 313 VAL A CB  1 ? 
ATOM   2460 C  CG1 . VAL A 1 313 ? 47.063 13.374  34.379 1.000 18.628 0 313 VAL A CG1 1 ? 
ATOM   2461 C  CG2 . VAL A 1 313 ? 49.219 12.077  34.107 1.000 18.753 0 313 VAL A CG2 1 ? 
ATOM   2462 N  N   . LEU A 1 314 ? 46.955 12.638  38.068 1.000 16.690 0 314 LEU A N   1 ? 
ATOM   2463 C  CA  . LEU A 1 314 ? 45.901 12.971  39.029 1.000 15.436 0 314 LEU A CA  1 ? 
ATOM   2464 C  C   . LEU A 1 314 ? 46.361 14.053  39.998 1.000 17.866 0 314 LEU A C   1 ? 
ATOM   2465 O  O   . LEU A 1 314 ? 45.559 14.923  40.411 1.000 18.917 0 314 LEU A O   1 ? 
ATOM   2466 C  CB  . LEU A 1 314 ? 45.437 11.722  39.768 1.000 17.790 0 314 LEU A CB  1 ? 
ATOM   2467 C  CG  . LEU A 1 314 ? 44.749 10.644  38.919 1.000 16.681 0 314 LEU A CG  1 ? 
ATOM   2468 C  CD1 . LEU A 1 314 ? 44.371 9.484   39.819 1.000 18.686 0 314 LEU A CD1 1 ? 
ATOM   2469 C  CD2 . LEU A 1 314 ? 43.546 11.095  38.136 1.000 18.756 0 314 LEU A CD2 1 ? 
ATOM   2470 N  N   . CYS A 1 315 ? 47.636 13.996  40.384 1.000 16.680 0 315 CYS A N   1 ? 
ATOM   2471 C  CA  . CYS A 1 315 ? 48.178 15.000  41.265 1.000 15.969 0 315 CYS A CA  1 ? 
ATOM   2472 C  C   . CYS A 1 315 ? 48.247 16.351  40.562 1.000 19.430 0 315 CYS A C   1 ? 
ATOM   2473 O  O   . CYS A 1 315 ? 48.021 17.411  41.173 1.000 21.853 0 315 CYS A O   1 ? 
ATOM   2474 C  CB  . CYS A 1 315 ? 49.575 14.569  41.702 1.000 16.890 0 315 CYS A CB  1 ? 
ATOM   2475 S  SG  . CYS A 1 315 ? 50.345 15.656  42.936 1.000 19.436 0 315 CYS A SG  1 ? 
ATOM   2476 N  N   . GLY A 1 316 ? 48.703 16.329  39.310 1.000 18.314 0 316 GLY A N   1 ? 
ATOM   2477 C  CA  . GLY A 1 316 ? 49.032 17.563  38.612 1.000 21.155 0 316 GLY A CA  1 ? 
ATOM   2478 C  C   . GLY A 1 316 ? 50.492 17.940  38.895 1.000 25.854 0 316 GLY A C   1 ? 
ATOM   2479 O  O   . GLY A 1 316 ? 51.132 17.441  39.850 1.000 24.743 0 316 GLY A O   1 ? 
ATOM   2480 N  N   . GLY A 1 317 ? 51.007 18.848  38.067 1.000 31.480 0 317 GLY A N   1 ? 
ATOM   2481 C  CA  . GLY A 1 317 ? 52.377 19.326  38.218 1.000 36.518 0 317 GLY A CA  1 ? 
ATOM   2482 C  C   . GLY A 1 317 ? 53.318 18.595  37.249 1.000 42.675 0 317 GLY A C   1 ? 
ATOM   2483 O  O   . GLY A 1 317 ? 52.856 18.035  36.247 1.000 50.332 0 317 GLY A O   1 ? 
ATOM   2484 N  N   . ASP A 1 318 ? 54.637 18.588  37.504 1.000 43.092 0 318 ASP A N   1 ? 
ATOM   2485 C  CA  . ASP A 1 318 ? 55.376 19.385  38.480 1.000 53.264 0 318 ASP A CA  1 ? 
ATOM   2486 C  C   . ASP A 1 318 ? 56.868 19.200  38.178 1.000 58.460 0 318 ASP A C   1 ? 
ATOM   2487 O  O   . ASP A 1 318 ? 57.621 18.841  39.081 1.000 72.173 0 318 ASP A O   1 ? 
ATOM   2488 C  CB  . ASP A 1 318 ? 55.084 18.993  39.927 1.000 60.079 0 318 ASP A CB  1 ? 
ATOM   2489 C  CG  . ASP A 1 318 ? 55.030 20.122  40.952 1.000 58.484 0 318 ASP A CG  1 ? 
ATOM   2490 O  OD1 . ASP A 1 318 ? 54.229 21.063  40.733 1.000 56.482 0 318 ASP A OD1 1 ? 
ATOM   2491 O  OD2 . ASP A 1 318 ? 55.740 20.021  41.992 1.000 62.245 0 318 ASP A OD2 1 ? 
ATOM   2492 N  N   . ASP A 1 319 ? 57.277 19.399  36.902 1.000 64.736 0 319 ASP A N   1 ? 
ATOM   2493 C  CA  . ASP A 1 319 ? 58.670 19.304  36.470 1.000 58.326 0 319 ASP A CA  1 ? 
ATOM   2494 C  C   . ASP A 1 319 ? 58.757 18.823  35.003 1.000 48.754 0 319 ASP A C   1 ? 
ATOM   2495 O  O   . ASP A 1 319 ? 59.838 18.271  34.597 1.000 32.137 0 319 ASP A O   1 ? 
ATOM   2496 C  CB  . ASP A 1 319 ? 59.537 18.534  37.473 1.000 64.933 0 319 ASP A CB  1 ? 
ATOM   2497 C  CG  . ASP A 1 319 ? 59.471 17.010  37.515 1.000 63.811 0 319 ASP A CG  1 ? 
ATOM   2498 O  OD1 . ASP A 1 319 ? 59.698 16.382  36.458 1.000 59.938 0 319 ASP A OD1 1 ? 
ATOM   2499 O  OD2 . ASP A 1 319 ? 59.286 16.461  38.627 1.000 76.600 0 319 ASP A OD2 1 ? 
HETATM 2500 CA CA  . CA  B 2 .   ? 46.288 -6.324  24.170 1.000 18.598 0 401 CA  A CA  1 ? 
HETATM 2501 CA CA  . CA  C 2 .   ? 34.407 -7.848  57.961 1.000 38.756 0 402 CA  A CA  1 ? 
HETATM 2502 CA CA  . CA  D 2 .   ? 57.043 4.759   51.507 1.000 29.473 0 403 CA  A CA  1 ? 
HETATM 2503 S  S   . SO4 E 3 .   ? 38.690 -3.734  15.716 1.000 35.390 0 404 SO4 A S   1 ? 
HETATM 2504 O  O1  . SO4 E 3 .   ? 39.218 -5.047  15.962 1.000 31.302 0 404 SO4 A O1  1 ? 
HETATM 2505 O  O2  . SO4 E 3 .   ? 38.183 -3.096  16.957 1.000 31.308 0 404 SO4 A O2  1 ? 
HETATM 2506 O  O3  . SO4 E 3 .   ? 39.708 -2.883  15.151 1.000 35.708 0 404 SO4 A O3  1 ? 
HETATM 2507 O  O4  . SO4 E 3 .   ? 37.557 -3.887  14.804 1.000 39.593 0 404 SO4 A O4  1 ? 
HETATM 2508 S  S   . SO4 F 3 .   ? 42.206 -8.539  20.520 1.000 58.421 0 405 SO4 A S   1 ? 
HETATM 2509 O  O1  . SO4 F 3 .   ? 41.984 -9.898  20.917 1.000 63.017 0 405 SO4 A O1  1 ? 
HETATM 2510 O  O2  . SO4 F 3 .   ? 41.939 -7.664  21.635 1.000 48.818 0 405 SO4 A O2  1 ? 
HETATM 2511 O  O3  . SO4 F 3 .   ? 43.572 -8.391  20.095 1.000 55.848 0 405 SO4 A O3  1 ? 
HETATM 2512 O  O4  . SO4 F 3 .   ? 41.311 -8.233  19.428 1.000 50.322 0 405 SO4 A O4  1 ? 
HETATM 2513 S  S   . SO4 G 3 .   ? 51.393 23.546  38.223 1.000 36.050 0 406 SO4 A S   1 ? 
HETATM 2514 O  O1  . SO4 G 3 .   ? 52.030 22.521  39.004 1.000 33.239 0 406 SO4 A O1  1 ? 
HETATM 2515 O  O2  . SO4 G 3 .   ? 51.948 24.798  38.605 1.000 32.565 0 406 SO4 A O2  1 ? 
HETATM 2516 O  O3  . SO4 G 3 .   ? 51.601 23.291  36.785 1.000 36.509 0 406 SO4 A O3  1 ? 
HETATM 2517 O  O4  . SO4 G 3 .   ? 49.983 23.540  38.494 1.000 50.874 0 406 SO4 A O4  1 ? 
HETATM 2518 S  S   . SO4 H 3 .   ? 12.974 8.818   50.590 1.000 74.236 0 407 SO4 A S   1 ? 
HETATM 2519 O  O1  . SO4 H 3 .   ? 12.309 7.549   50.428 1.000 75.033 0 407 SO4 A O1  1 ? 
HETATM 2520 O  O2  . SO4 H 3 .   ? 12.661 9.361   51.885 1.000 61.122 0 407 SO4 A O2  1 ? 
HETATM 2521 O  O3  . SO4 H 3 .   ? 14.400 8.622   50.453 1.000 60.878 0 407 SO4 A O3  1 ? 
HETATM 2522 O  O4  . SO4 H 3 .   ? 12.512 9.732   49.578 1.000 63.867 0 407 SO4 A O4  1 ? 
HETATM 2523 O  O   . HOH I 4 .   ? 40.624 23.813  39.905 1.000 29.441 0 501 HOH A O   1 ? 
HETATM 2524 O  O   . HOH I 4 .   ? 39.103 5.740   73.997 1.000 30.596 0 502 HOH A O   1 ? 
HETATM 2525 O  O   . HOH I 4 .   ? 21.451 14.841  58.395 1.000 28.846 0 503 HOH A O   1 ? 
HETATM 2526 O  O   . HOH I 4 .   ? 25.917 20.272  75.794 1.000 31.818 0 504 HOH A O   1 ? 
HETATM 2527 O  O   . HOH I 4 .   ? 42.798 4.604   55.085 1.000 32.639 0 505 HOH A O   1 ? 
HETATM 2528 O  O   . HOH I 4 .   ? 32.268 27.534  80.152 1.000 38.409 0 506 HOH A O   1 ? 
HETATM 2529 O  O   . HOH I 4 .   ? 43.292 18.114  77.417 1.000 39.528 0 507 HOH A O   1 ? 
HETATM 2530 O  O   . HOH I 4 .   ? 36.702 -0.315  44.960 1.000 34.064 0 508 HOH A O   1 ? 
HETATM 2531 O  O   . HOH I 4 .   ? 47.706 4.805   55.292 1.000 26.169 0 509 HOH A O   1 ? 
HETATM 2532 O  O   . HOH I 4 .   ? 60.801 11.799  45.410 1.000 34.691 0 510 HOH A O   1 ? 
HETATM 2533 O  O   . HOH I 4 .   ? 34.681 10.791  41.001 1.000 30.972 0 511 HOH A O   1 ? 
HETATM 2534 O  O   . HOH I 4 .   ? 43.566 13.644  26.132 1.000 31.576 0 512 HOH A O   1 ? 
HETATM 2535 O  O   . HOH I 4 .   ? 17.127 13.286  47.388 1.000 27.123 0 513 HOH A O   1 ? 
HETATM 2536 O  O   . HOH I 4 .   ? 22.247 18.131  67.936 1.000 29.832 0 514 HOH A O   1 ? 
HETATM 2537 O  O   . HOH I 4 .   ? 43.301 1.827   55.498 1.000 29.663 0 515 HOH A O   1 ? 
HETATM 2538 O  O   . HOH I 4 .   ? 61.916 10.317  55.042 1.000 34.854 0 516 HOH A O   1 ? 
HETATM 2539 O  O   . HOH I 4 .   ? 23.608 21.540  65.656 1.000 21.814 0 517 HOH A O   1 ? 
HETATM 2540 O  O   . HOH I 4 .   ? 31.487 -4.671  45.225 1.000 27.497 0 518 HOH A O   1 ? 
HETATM 2541 O  O   . HOH I 4 .   ? 21.303 30.522  72.392 1.000 26.583 0 519 HOH A O   1 ? 
HETATM 2542 O  O   . HOH I 4 .   ? 41.876 24.718  51.948 1.000 35.777 0 520 HOH A O   1 ? 
HETATM 2543 O  O   . HOH I 4 .   ? 26.694 17.392  49.836 1.000 23.834 0 521 HOH A O   1 ? 
HETATM 2544 O  O   . HOH I 4 .   ? 39.188 10.224  39.595 1.000 28.881 0 522 HOH A O   1 ? 
HETATM 2545 O  O   . HOH I 4 .   ? 20.586 -8.817  53.352 1.000 25.302 0 523 HOH A O   1 ? 
HETATM 2546 O  O   . HOH I 4 .   ? 23.752 -6.024  42.345 1.000 32.451 0 524 HOH A O   1 ? 
HETATM 2547 O  O   . HOH I 4 .   ? 41.681 9.134   59.557 1.000 20.907 0 525 HOH A O   1 ? 
HETATM 2548 O  O   . HOH I 4 .   ? 46.280 -1.464  17.858 1.000 31.967 0 526 HOH A O   1 ? 
HETATM 2549 O  O   . HOH I 4 .   ? 28.111 4.690   33.847 1.000 27.186 0 527 HOH A O   1 ? 
HETATM 2550 O  O   . HOH I 4 .   ? 29.865 12.497  57.513 1.000 21.954 0 528 HOH A O   1 ? 
HETATM 2551 O  O   . HOH I 4 .   ? 51.128 6.373   23.029 1.000 39.403 0 529 HOH A O   1 ? 
HETATM 2552 O  O   . HOH I 4 .   ? 51.512 25.397  50.341 1.000 30.443 0 530 HOH A O   1 ? 
HETATM 2553 O  O   . HOH I 4 .   ? 38.206 17.516  77.594 1.000 27.434 0 531 HOH A O   1 ? 
HETATM 2554 O  O   . HOH I 4 .   ? 33.460 2.229   14.678 1.000 34.524 0 532 HOH A O   1 ? 
HETATM 2555 O  O   . HOH I 4 .   ? 23.784 25.952  66.880 1.000 23.140 0 533 HOH A O   1 ? 
HETATM 2556 O  O   . HOH I 4 .   ? 37.583 20.298  50.204 1.000 29.321 0 534 HOH A O   1 ? 
HETATM 2557 O  O   . HOH I 4 .   ? 39.924 -1.889  51.912 1.000 36.060 0 535 HOH A O   1 ? 
HETATM 2558 O  O   . HOH I 4 .   ? 57.946 14.819  57.532 1.000 38.633 0 536 HOH A O   1 ? 
HETATM 2559 O  O   . HOH I 4 .   ? 61.836 16.812  39.396 1.000 27.970 0 537 HOH A O   1 ? 
HETATM 2560 O  O   . HOH I 4 .   ? 35.744 7.157   40.489 1.000 18.239 0 538 HOH A O   1 ? 
HETATM 2561 O  O   . HOH I 4 .   ? 41.937 10.199  62.074 1.000 30.373 0 539 HOH A O   1 ? 
HETATM 2562 O  O   . HOH I 4 .   ? 39.584 0.053   41.548 1.000 28.960 0 540 HOH A O   1 ? 
HETATM 2563 O  O   . HOH I 4 .   ? 30.116 -5.791  65.951 1.000 30.481 0 541 HOH A O   1 ? 
HETATM 2564 O  O   . HOH I 4 .   ? 26.289 2.174   23.821 1.000 24.393 0 542 HOH A O   1 ? 
HETATM 2565 O  O   . HOH I 4 .   ? 28.186 10.953  32.027 1.000 21.391 0 543 HOH A O   1 ? 
HETATM 2566 O  O   . HOH I 4 .   ? 41.298 1.411   47.492 1.000 21.412 0 544 HOH A O   1 ? 
HETATM 2567 O  O   . HOH I 4 .   ? 40.495 1.547   44.636 1.000 22.093 0 545 HOH A O   1 ? 
HETATM 2568 O  O   . HOH I 4 .   ? 50.693 -5.868  19.150 1.000 29.652 0 546 HOH A O   1 ? 
HETATM 2569 O  O   . HOH I 4 .   ? 31.768 27.454  77.631 1.000 30.793 0 547 HOH A O   1 ? 
HETATM 2570 O  O   . HOH I 4 .   ? 53.930 25.903  37.126 1.000 21.223 0 548 HOH A O   1 ? 
HETATM 2571 O  O   . HOH I 4 .   ? 38.241 -8.317  27.286 1.000 36.968 0 549 HOH A O   1 ? 
HETATM 2572 O  O   . HOH I 4 .   ? 20.757 24.592  61.224 1.000 26.864 0 550 HOH A O   1 ? 
HETATM 2573 O  O   . HOH I 4 .   ? 37.748 13.137  41.811 1.000 28.235 0 551 HOH A O   1 ? 
HETATM 2574 O  O   . HOH I 4 .   ? 38.209 19.884  39.013 1.000 34.460 0 552 HOH A O   1 ? 
HETATM 2575 O  O   . HOH I 4 .   ? 48.189 23.903  44.915 1.000 31.935 0 553 HOH A O   1 ? 
HETATM 2576 O  O   . HOH I 4 .   ? 39.794 23.635  69.793 1.000 23.660 0 554 HOH A O   1 ? 
HETATM 2577 O  O   . HOH I 4 .   ? 38.840 12.144  37.893 1.000 23.589 0 555 HOH A O   1 ? 
HETATM 2578 O  O   . HOH I 4 .   ? 61.799 20.221  53.147 1.000 26.972 0 556 HOH A O   1 ? 
HETATM 2579 O  O   . HOH I 4 .   ? 30.254 16.656  80.604 1.000 30.684 0 557 HOH A O   1 ? 
HETATM 2580 O  O   . HOH I 4 .   ? 36.164 5.870   47.590 1.000 35.740 0 558 HOH A O   1 ? 
HETATM 2581 O  O   . HOH I 4 .   ? 41.106 10.286  21.703 1.000 21.852 0 559 HOH A O   1 ? 
HETATM 2582 O  O   . HOH I 4 .   ? 23.359 10.230  62.388 1.000 23.979 0 560 HOH A O   1 ? 
HETATM 2583 O  O   . HOH I 4 .   ? 46.533 7.253   55.401 1.000 20.555 0 561 HOH A O   1 ? 
HETATM 2584 O  O   . HOH I 4 .   ? 36.008 -4.510  18.037 1.000 28.547 0 562 HOH A O   1 ? 
HETATM 2585 O  O   . HOH I 4 .   ? 28.538 8.236   24.739 1.000 28.106 0 563 HOH A O   1 ? 
HETATM 2586 O  O   . HOH I 4 .   ? 42.287 1.686   52.358 1.000 22.867 0 564 HOH A O   1 ? 
HETATM 2587 O  O   . HOH I 4 .   ? 37.941 -8.703  31.870 1.000 27.739 0 565 HOH A O   1 ? 
HETATM 2588 O  O   . HOH I 4 .   ? 21.365 12.567  49.091 1.000 29.263 0 566 HOH A O   1 ? 
HETATM 2589 O  O   . HOH I 4 .   ? 52.259 19.759  47.202 1.000 19.386 0 567 HOH A O   1 ? 
HETATM 2590 O  O   . HOH I 4 .   ? 44.285 -4.770  40.482 1.000 32.833 0 568 HOH A O   1 ? 
HETATM 2591 O  O   . HOH I 4 .   ? 19.886 4.074   53.101 1.000 31.122 0 569 HOH A O   1 ? 
HETATM 2592 O  O   . HOH I 4 .   ? 19.673 24.800  68.810 1.000 28.419 0 570 HOH A O   1 ? 
HETATM 2593 O  O   . HOH I 4 .   ? 34.161 8.663   44.932 1.000 21.017 0 571 HOH A O   1 ? 
HETATM 2594 O  O   . HOH I 4 .   ? 47.372 9.741   70.416 1.000 34.678 0 572 HOH A O   1 ? 
HETATM 2595 O  O   . HOH I 4 .   ? 38.249 -0.384  50.340 1.000 28.893 0 573 HOH A O   1 ? 
HETATM 2596 O  O   . HOH I 4 .   ? 52.577 11.281  34.471 1.000 24.138 0 574 HOH A O   1 ? 
HETATM 2597 O  O   . HOH I 4 .   ? 44.628 0.418   53.620 1.000 31.781 0 575 HOH A O   1 ? 
HETATM 2598 O  O   . HOH I 4 .   ? 48.265 21.394  38.428 1.000 33.276 0 576 HOH A O   1 ? 
HETATM 2599 O  O   . HOH I 4 .   ? 38.280 13.570  22.870 1.000 21.044 0 577 HOH A O   1 ? 
HETATM 2600 O  O   . HOH I 4 .   ? 39.426 26.180  67.363 1.000 31.463 0 578 HOH A O   1 ? 
HETATM 2601 O  O   . HOH I 4 .   ? 19.126 19.600  60.714 1.000 36.931 0 579 HOH A O   1 ? 
HETATM 2602 O  O   . HOH I 4 .   ? 26.708 11.634  62.597 1.000 20.653 0 580 HOH A O   1 ? 
HETATM 2603 O  O   . HOH I 4 .   ? 40.604 17.557  30.959 1.000 31.351 0 581 HOH A O   1 ? 
HETATM 2604 O  O   . HOH I 4 .   ? 41.852 -6.338  24.393 1.000 21.860 0 582 HOH A O   1 ? 
HETATM 2605 O  O   . HOH I 4 .   ? 34.551 31.401  71.777 1.000 28.270 0 583 HOH A O   1 ? 
HETATM 2606 O  O   . HOH I 4 .   ? 26.977 24.388  59.223 1.000 23.199 0 584 HOH A O   1 ? 
HETATM 2607 O  O   . HOH I 4 .   ? 29.579 1.273   36.616 1.000 30.617 0 585 HOH A O   1 ? 
HETATM 2608 O  O   . HOH I 4 .   ? 38.053 9.424   50.098 1.000 23.573 0 586 HOH A O   1 ? 
HETATM 2609 O  O   . HOH I 4 .   ? 32.712 14.074  36.811 1.000 22.616 0 587 HOH A O   1 ? 
HETATM 2610 O  O   . HOH I 4 .   ? 28.604 -2.801  43.121 1.000 37.927 0 588 HOH A O   1 ? 
HETATM 2611 O  O   . HOH I 4 .   ? 26.562 7.636   28.676 1.000 37.083 0 589 HOH A O   1 ? 
HETATM 2612 O  O   . HOH I 4 .   ? 46.342 -7.803  39.011 1.000 30.622 0 590 HOH A O   1 ? 
HETATM 2613 O  O   . HOH I 4 .   ? 43.695 16.010  34.125 1.000 26.115 0 591 HOH A O   1 ? 
HETATM 2614 O  O   . HOH I 4 .   ? 32.007 -0.030  27.751 1.000 20.146 0 592 HOH A O   1 ? 
HETATM 2615 O  O   . HOH I 4 .   ? 27.092 11.645  57.962 1.000 26.507 0 593 HOH A O   1 ? 
HETATM 2616 O  O   . HOH I 4 .   ? 33.710 -7.628  63.422 1.000 33.971 0 594 HOH A O   1 ? 
HETATM 2617 O  O   . HOH I 4 .   ? 37.526 22.091  40.975 1.000 34.279 0 595 HOH A O   1 ? 
HETATM 2618 O  O   . HOH I 4 .   ? 45.959 4.463   21.134 1.000 22.751 0 596 HOH A O   1 ? 
HETATM 2619 O  O   . HOH I 4 .   ? 22.102 1.022   53.424 1.000 18.550 0 597 HOH A O   1 ? 
HETATM 2620 O  O   . HOH I 4 .   ? 21.525 -4.565  42.383 1.000 29.840 0 598 HOH A O   1 ? 
HETATM 2621 O  O   . HOH I 4 .   ? 34.303 19.075  25.324 1.000 23.718 0 599 HOH A O   1 ? 
HETATM 2622 O  O   . HOH I 4 .   ? 30.126 -7.225  55.494 1.000 34.388 0 600 HOH A O   1 ? 
HETATM 2623 O  O   . HOH I 4 .   ? 59.166 5.694   51.683 1.000 35.379 0 601 HOH A O   1 ? 
HETATM 2624 O  O   . HOH I 4 .   ? 41.552 6.756   58.336 1.000 35.409 0 602 HOH A O   1 ? 
HETATM 2625 O  O   . HOH I 4 .   ? 24.681 5.722   42.672 1.000 31.602 0 603 HOH A O   1 ? 
HETATM 2626 O  O   . HOH I 4 .   ? 57.967 15.558  55.051 1.000 30.501 0 604 HOH A O   1 ? 
HETATM 2627 O  O   . HOH I 4 .   ? 44.742 -9.268  33.372 1.000 36.917 0 605 HOH A O   1 ? 
HETATM 2628 O  O   . HOH I 4 .   ? 40.558 -4.026  23.444 1.000 20.251 0 606 HOH A O   1 ? 
HETATM 2629 O  O   . HOH I 4 .   ? 36.434 -1.001  69.419 1.000 31.151 0 607 HOH A O   1 ? 
HETATM 2630 O  O   . HOH I 4 .   ? 53.864 -1.572  50.845 1.000 39.590 0 608 HOH A O   1 ? 
HETATM 2631 O  O   . HOH I 4 .   ? 50.816 14.185  60.087 1.000 34.589 0 609 HOH A O   1 ? 
HETATM 2632 O  O   . HOH I 4 .   ? 33.941 -3.923  46.410 1.000 24.850 0 610 HOH A O   1 ? 
HETATM 2633 O  O   . HOH I 4 .   ? 32.906 30.292  69.580 1.000 31.948 0 611 HOH A O   1 ? 
HETATM 2634 O  O   . HOH I 4 .   ? 18.097 -3.532  55.255 1.000 29.201 0 612 HOH A O   1 ? 
HETATM 2635 O  O   . HOH I 4 .   ? 41.760 17.719  33.210 1.000 32.927 0 613 HOH A O   1 ? 
HETATM 2636 O  O   . HOH I 4 .   ? 31.322 17.011  32.862 1.000 32.712 0 614 HOH A O   1 ? 
HETATM 2637 O  O   . HOH I 4 .   ? 36.166 -2.034  65.994 1.000 29.801 0 615 HOH A O   1 ? 
HETATM 2638 O  O   . HOH I 4 .   ? 30.338 -10.098 54.159 1.000 40.590 0 616 HOH A O   1 ? 
HETATM 2639 O  O   . HOH I 4 .   ? 24.718 17.475  53.639 1.000 20.800 0 617 HOH A O   1 ? 
HETATM 2640 O  O   . HOH I 4 .   ? 22.130 1.681   56.106 1.000 29.809 0 618 HOH A O   1 ? 
HETATM 2641 O  O   . HOH I 4 .   ? 37.142 9.114   39.346 1.000 22.779 0 619 HOH A O   1 ? 
HETATM 2642 O  O   . HOH I 4 .   ? 29.947 14.331  59.453 1.000 29.492 0 620 HOH A O   1 ? 
HETATM 2643 O  O   . HOH I 4 .   ? 43.524 -1.823  52.751 1.000 31.027 0 621 HOH A O   1 ? 
HETATM 2644 O  O   . HOH I 4 .   ? 34.357 31.683  67.723 1.000 34.791 0 622 HOH A O   1 ? 
HETATM 2645 O  O   . HOH I 4 .   ? 35.336 12.465  47.657 1.000 31.420 0 623 HOH A O   1 ? 
HETATM 2646 O  O   . HOH I 4 .   ? 48.091 3.059   20.830 1.000 23.218 0 624 HOH A O   1 ? 
HETATM 2647 O  O   . HOH I 4 .   ? 44.967 -8.178  23.383 1.000 25.847 0 625 HOH A O   1 ? 
HETATM 2648 O  O   . HOH I 4 .   ? 40.799 20.081  27.605 1.000 40.124 0 626 HOH A O   1 ? 
HETATM 2649 O  O   . HOH I 4 .   ? 28.132 4.255   30.705 1.000 34.582 0 627 HOH A O   1 ? 
HETATM 2650 O  O   . HOH I 4 .   ? 21.953 31.245  63.276 1.000 32.573 0 628 HOH A O   1 ? 
HETATM 2651 O  O   . HOH I 4 .   ? 52.758 2.510   27.164 1.000 33.527 0 629 HOH A O   1 ? 
HETATM 2652 O  O   . HOH I 4 .   ? 60.170 5.454   42.790 1.000 32.898 0 630 HOH A O   1 ? 
HETATM 2653 O  O   . HOH I 4 .   ? 39.504 18.294  80.019 1.000 37.285 0 631 HOH A O   1 ? 
HETATM 2654 O  O   . HOH I 4 .   ? 41.652 -0.717  16.734 1.000 32.601 0 632 HOH A O   1 ? 
HETATM 2655 O  O   . HOH I 4 .   ? 42.033 19.708  59.255 1.000 25.217 0 633 HOH A O   1 ? 
HETATM 2656 O  O   . HOH I 4 .   ? 47.080 -1.163  50.527 1.000 29.027 0 634 HOH A O   1 ? 
HETATM 2657 O  O   . HOH I 4 .   ? 36.270 -7.079  18.838 1.000 32.986 0 635 HOH A O   1 ? 
HETATM 2658 O  O   . HOH I 4 .   ? 38.662 2.278   69.874 1.000 26.949 0 636 HOH A O   1 ? 
HETATM 2659 O  O   . HOH I 4 .   ? 27.708 10.506  47.463 1.000 32.584 0 637 HOH A O   1 ? 
HETATM 2660 O  O   . HOH I 4 .   ? 36.728 21.668  54.268 1.000 36.046 0 638 HOH A O   1 ? 
HETATM 2661 O  O   . HOH I 4 .   ? 35.135 1.643   73.019 1.000 29.101 0 639 HOH A O   1 ? 
HETATM 2662 O  O   . HOH I 4 .   ? 29.894 9.795   38.606 1.000 31.918 0 640 HOH A O   1 ? 
HETATM 2663 O  O   . HOH I 4 .   ? 23.791 12.181  64.180 1.000 27.239 0 641 HOH A O   1 ? 
HETATM 2664 O  O   . HOH I 4 .   ? 42.854 0.350   58.839 1.000 32.653 0 642 HOH A O   1 ? 
HETATM 2665 O  O   . HOH I 4 .   ? 52.344 18.535  44.410 1.000 19.548 0 643 HOH A O   1 ? 
HETATM 2666 O  O   . HOH I 4 .   ? 35.986 1.515   70.419 1.000 25.604 0 644 HOH A O   1 ? 
HETATM 2667 O  O   . HOH I 4 .   ? 40.254 0.438   68.910 1.000 38.416 0 645 HOH A O   1 ? 
HETATM 2668 O  O   . HOH I 4 .   ? 34.515 11.528  45.542 1.000 29.666 0 646 HOH A O   1 ? 
HETATM 2669 O  O   . HOH I 4 .   ? 27.896 8.672   40.849 1.000 23.948 0 647 HOH A O   1 ? 
HETATM 2670 O  O   . HOH I 4 .   ? 39.024 -0.385  43.980 1.000 40.794 0 648 HOH A O   1 ? 
HETATM 2671 O  O   . HOH I 4 .   ? 25.587 12.100  60.161 1.000 25.110 0 649 HOH A O   1 ? 
HETATM 2672 O  O   . HOH I 4 .   ? 53.739 3.914   54.396 1.000 38.561 0 650 HOH A O   1 ? 
HETATM 2673 O  O   . HOH I 4 .   ? 26.245 20.290  59.270 1.000 31.683 0 651 HOH A O   1 ? 
HETATM 2674 O  O   . HOH I 4 .   ? 34.895 22.147  23.198 1.000 38.641 0 652 HOH A O   1 ? 
HETATM 2675 O  O   . HOH I 4 .   ? 58.256 3.177   50.299 1.000 36.832 0 653 HOH A O   1 ? 
HETATM 2676 O  O   . HOH I 4 .   ? 47.465 -7.819  25.526 1.000 25.707 0 654 HOH A O   1 ? 
HETATM 2677 O  O   . HOH I 4 .   ? 30.958 12.466  38.477 1.000 30.773 0 655 HOH A O   1 ? 
HETATM 2678 O  O   . HOH I 4 .   ? 27.065 5.958   41.035 1.000 23.528 0 656 HOH A O   1 ? 
HETATM 2679 O  O   . HOH I 4 .   ? 36.655 0.415   41.273 1.000 32.852 0 657 HOH A O   1 ? 
HETATM 2680 O  O   . HOH I 4 .   ? 30.481 1.043   73.556 1.000 38.176 0 658 HOH A O   1 ? 
HETATM 2681 O  O   . HOH I 4 .   ? 45.401 -8.815  36.482 1.000 34.260 0 659 HOH A O   1 ? 
HETATM 2682 O  O   . HOH I 4 .   ? 24.616 13.596  30.124 1.000 44.668 0 660 HOH A O   1 ? 
HETATM 2683 O  O   . HOH I 4 .   ? 25.929 -0.226  22.055 1.000 26.505 0 661 HOH A O   1 ? 
HETATM 2684 O  O   . HOH I 4 .   ? 58.321 10.199  37.467 1.000 27.496 0 662 HOH A O   1 ? 
HETATM 2685 O  O   . HOH I 4 .   ? 56.686 8.863   35.666 1.000 28.158 0 663 HOH A O   1 ? 
HETATM 2686 O  O   . HOH I 4 .   ? 26.499 8.825   31.214 1.000 32.078 0 664 HOH A O   1 ? 
HETATM 2687 O  O   . HOH I 4 .   ? 35.676 8.893   42.686 1.000 17.901 0 665 HOH A O   1 ? 
HETATM 2688 O  O   . HOH I 4 .   ? 21.774 24.258  67.315 1.000 30.038 0 666 HOH A O   1 ? 
HETATM 2689 O  O   . HOH I 4 .   ? 46.040 7.716   58.005 1.000 26.376 0 667 HOH A O   1 ? 
HETATM 2690 O  O   . HOH I 4 .   ? 31.244 -7.603  46.679 1.000 40.789 0 668 HOH A O   1 ? 
HETATM 2691 O  O   . HOH I 4 .   ? 56.986 2.420   27.294 1.000 41.597 0 669 HOH A O   1 ? 
HETATM 2692 O  O   . HOH I 4 .   ? 21.443 8.710   63.726 1.000 37.816 0 670 HOH A O   1 ? 
HETATM 2693 O  O   . HOH I 4 .   ? 47.025 7.064   20.927 1.000 29.284 0 671 HOH A O   1 ? 
# 
