data_9GA6
# 
_entry.id   9GA6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GA6         pdb_00009ga6 10.2210/pdb9ga6/pdb 
WWPDB D_1292140077 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-04 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GA6 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 alessia.ruggiero@unina.it Alessia Ruggiero   ? 'principal investigator/group leader' 0000-0002-3508-385X 
4 luigi.vitagliano@cnr.it   Luigi   Vitagliano ? 'principal investigator/group leader' 0000-0002-3032-3375 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Vitagliano, L.' 1 ? 
'Barra, G.'      2 ? 
'Ghilardi, O.'   3 ? 
'Di Micco, S.'   4 ? 
'Bifulco, G.'    5 ? 
'Campiglia, P.'  6 ? 
'Sala, M.'       7 ? 
'Scala, M.C.'    8 ? 
'Ruggiero, A.'   9 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            308 
_citation.language                  ? 
_citation.page_first                142600 
_citation.page_last                 142600 
_citation.title                     
;Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.142600 
_citation.pdbx_database_id_PubMed   40157693 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Di Micco, S.'   1 ? 
primary 'Scala, M.C.'    2 ? 
primary 'Sala, M.'       3 ? 
primary 'Barra, G.'      4 ? 
primary 'Ghilardi, O.'   5 ? 
primary 'Campiglia, P.'  6 ? 
primary 'Bifulco, G.'    7 ? 
primary 'Vitagliano, L.' 8 ? 
primary 'Ruggiero, A.'   9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Annexin A4'  36760.605 1   ? ? ? ? 
2 non-polymer syn 'CALCIUM ION' 40.078    3   ? ? ? ? 
3 non-polymer syn GLYCEROL      92.094    3   ? ? ? ? 
4 non-polymer syn 'SULFATE ION' 96.063    6   ? ? ? ? 
5 water       nat water         18.015    285 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;35-beta calcimedin,Annexin IV,Annexin-4,Carbohydrate-binding protein p33/p41,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PP4-X,Placental anticoagulant protein II,PAP-II,Protein II
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDDH
HHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDDH
HHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION' CA  
3 GLYCEROL      GOL 
4 'SULFATE ION' SO4 
5 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   LYS n 
1 5   GLY n 
1 6   GLY n 
1 7   THR n 
1 8   VAL n 
1 9   LYS n 
1 10  ALA n 
1 11  ALA n 
1 12  SER n 
1 13  GLY n 
1 14  PHE n 
1 15  ASN n 
1 16  ALA n 
1 17  MET n 
1 18  GLU n 
1 19  ASP n 
1 20  ALA n 
1 21  GLN n 
1 22  THR n 
1 23  LEU n 
1 24  ARG n 
1 25  LYS n 
1 26  ALA n 
1 27  MET n 
1 28  LYS n 
1 29  GLY n 
1 30  LEU n 
1 31  GLY n 
1 32  THR n 
1 33  ASP n 
1 34  GLU n 
1 35  ASP n 
1 36  ALA n 
1 37  ILE n 
1 38  ILE n 
1 39  SER n 
1 40  VAL n 
1 41  LEU n 
1 42  ALA n 
1 43  TYR n 
1 44  ARG n 
1 45  ASN n 
1 46  THR n 
1 47  ALA n 
1 48  GLN n 
1 49  ARG n 
1 50  GLN n 
1 51  GLU n 
1 52  ILE n 
1 53  ARG n 
1 54  THR n 
1 55  ALA n 
1 56  TYR n 
1 57  LYS n 
1 58  SER n 
1 59  THR n 
1 60  ILE n 
1 61  GLY n 
1 62  ARG n 
1 63  ASP n 
1 64  LEU n 
1 65  ILE n 
1 66  ASP n 
1 67  ASP n 
1 68  LEU n 
1 69  LYS n 
1 70  SER n 
1 71  GLU n 
1 72  LEU n 
1 73  SER n 
1 74  GLY n 
1 75  ASN n 
1 76  PHE n 
1 77  GLU n 
1 78  GLN n 
1 79  VAL n 
1 80  ILE n 
1 81  VAL n 
1 82  GLY n 
1 83  MET n 
1 84  MET n 
1 85  THR n 
1 86  PRO n 
1 87  THR n 
1 88  VAL n 
1 89  LEU n 
1 90  TYR n 
1 91  ASP n 
1 92  VAL n 
1 93  GLN n 
1 94  GLU n 
1 95  LEU n 
1 96  ARG n 
1 97  ARG n 
1 98  ALA n 
1 99  MET n 
1 100 LYS n 
1 101 GLY n 
1 102 ALA n 
1 103 GLY n 
1 104 THR n 
1 105 ASP n 
1 106 GLU n 
1 107 GLY n 
1 108 CYS n 
1 109 LEU n 
1 110 ILE n 
1 111 GLU n 
1 112 ILE n 
1 113 LEU n 
1 114 ALA n 
1 115 SER n 
1 116 ARG n 
1 117 THR n 
1 118 PRO n 
1 119 GLU n 
1 120 GLU n 
1 121 ILE n 
1 122 ARG n 
1 123 ARG n 
1 124 ILE n 
1 125 SER n 
1 126 GLN n 
1 127 THR n 
1 128 TYR n 
1 129 GLN n 
1 130 GLN n 
1 131 GLN n 
1 132 TYR n 
1 133 GLY n 
1 134 ARG n 
1 135 SER n 
1 136 LEU n 
1 137 GLU n 
1 138 ASP n 
1 139 ASP n 
1 140 ILE n 
1 141 ARG n 
1 142 SER n 
1 143 ASP n 
1 144 THR n 
1 145 SER n 
1 146 PHE n 
1 147 MET n 
1 148 PHE n 
1 149 GLN n 
1 150 ARG n 
1 151 VAL n 
1 152 LEU n 
1 153 VAL n 
1 154 SER n 
1 155 LEU n 
1 156 SER n 
1 157 ALA n 
1 158 GLY n 
1 159 GLY n 
1 160 ARG n 
1 161 ASP n 
1 162 GLU n 
1 163 GLY n 
1 164 ASN n 
1 165 TYR n 
1 166 LEU n 
1 167 ASP n 
1 168 ASP n 
1 169 ALA n 
1 170 LEU n 
1 171 VAL n 
1 172 ARG n 
1 173 GLN n 
1 174 ASP n 
1 175 ALA n 
1 176 GLN n 
1 177 ASP n 
1 178 LEU n 
1 179 TYR n 
1 180 GLU n 
1 181 ALA n 
1 182 GLY n 
1 183 GLU n 
1 184 LYS n 
1 185 LYS n 
1 186 TRP n 
1 187 GLY n 
1 188 THR n 
1 189 ASP n 
1 190 GLU n 
1 191 VAL n 
1 192 LYS n 
1 193 PHE n 
1 194 LEU n 
1 195 THR n 
1 196 VAL n 
1 197 LEU n 
1 198 CYS n 
1 199 SER n 
1 200 ARG n 
1 201 ASN n 
1 202 ARG n 
1 203 ASN n 
1 204 HIS n 
1 205 LEU n 
1 206 LEU n 
1 207 HIS n 
1 208 VAL n 
1 209 PHE n 
1 210 ASP n 
1 211 GLU n 
1 212 TYR n 
1 213 LYS n 
1 214 ARG n 
1 215 ILE n 
1 216 SER n 
1 217 GLN n 
1 218 LYS n 
1 219 ASP n 
1 220 ILE n 
1 221 GLU n 
1 222 GLN n 
1 223 SER n 
1 224 ILE n 
1 225 LYS n 
1 226 SER n 
1 227 GLU n 
1 228 THR n 
1 229 SER n 
1 230 GLY n 
1 231 SER n 
1 232 PHE n 
1 233 GLU n 
1 234 ASP n 
1 235 ALA n 
1 236 LEU n 
1 237 LEU n 
1 238 ALA n 
1 239 ILE n 
1 240 VAL n 
1 241 LYS n 
1 242 CYS n 
1 243 MET n 
1 244 ARG n 
1 245 ASN n 
1 246 LYS n 
1 247 SER n 
1 248 ALA n 
1 249 TYR n 
1 250 PHE n 
1 251 ALA n 
1 252 GLU n 
1 253 LYS n 
1 254 LEU n 
1 255 TYR n 
1 256 LYS n 
1 257 SER n 
1 258 MET n 
1 259 LYS n 
1 260 GLY n 
1 261 LEU n 
1 262 GLY n 
1 263 THR n 
1 264 ASP n 
1 265 ASP n 
1 266 ASN n 
1 267 THR n 
1 268 LEU n 
1 269 ILE n 
1 270 ARG n 
1 271 VAL n 
1 272 MET n 
1 273 VAL n 
1 274 SER n 
1 275 ARG n 
1 276 ALA n 
1 277 GLU n 
1 278 ILE n 
1 279 ASP n 
1 280 MET n 
1 281 LEU n 
1 282 ASP n 
1 283 ILE n 
1 284 ARG n 
1 285 ALA n 
1 286 HIS n 
1 287 PHE n 
1 288 LYS n 
1 289 ARG n 
1 290 LEU n 
1 291 TYR n 
1 292 GLY n 
1 293 LYS n 
1 294 SER n 
1 295 LEU n 
1 296 TYR n 
1 297 SER n 
1 298 PHE n 
1 299 ILE n 
1 300 LYS n 
1 301 GLY n 
1 302 ASP n 
1 303 THR n 
1 304 SER n 
1 305 GLY n 
1 306 ASP n 
1 307 TYR n 
1 308 ARG n 
1 309 LYS n 
1 310 VAL n 
1 311 LEU n 
1 312 LEU n 
1 313 VAL n 
1 314 LEU n 
1 315 CYS n 
1 316 GLY n 
1 317 GLY n 
1 318 ASP n 
1 319 ASP n 
1 320 HIS n 
1 321 HIS n 
1 322 HIS n 
1 323 HIS n 
1 324 HIS n 
1 325 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   325 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'ANXA4, ANX4' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ?                               'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'   ?                               'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   LYS 4   4   4   LYS LYS A . n 
A 1 5   GLY 5   5   5   GLY GLY A . n 
A 1 6   GLY 6   6   6   GLY GLY A . n 
A 1 7   THR 7   7   7   THR THR A . n 
A 1 8   VAL 8   8   8   VAL VAL A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  SER 12  12  12  SER SER A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  PHE 14  14  14  PHE PHE A . n 
A 1 15  ASN 15  15  15  ASN ASN A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  ASP 19  19  19  ASP ASP A . n 
A 1 20  ALA 20  20  20  ALA ALA A . n 
A 1 21  GLN 21  21  21  GLN GLN A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  ARG 24  24  24  ARG ARG A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  MET 27  27  27  MET MET A . n 
A 1 28  LYS 28  28  28  LYS LYS A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  THR 32  32  32  THR THR A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  ILE 37  37  37  ILE ILE A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  VAL 40  40  40  VAL VAL A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  TYR 43  43  43  TYR TYR A . n 
A 1 44  ARG 44  44  44  ARG ARG A . n 
A 1 45  ASN 45  45  45  ASN ASN A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  ALA 47  47  47  ALA ALA A . n 
A 1 48  GLN 48  48  48  GLN GLN A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  GLN 50  50  50  GLN GLN A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  TYR 56  56  56  TYR TYR A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  THR 59  59  59  THR THR A . n 
A 1 60  ILE 60  60  60  ILE ILE A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  ARG 62  62  62  ARG ARG A . n 
A 1 63  ASP 63  63  63  ASP ASP A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  ASP 66  66  66  ASP ASP A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  PHE 76  76  76  PHE PHE A . n 
A 1 77  GLU 77  77  77  GLU GLU A . n 
A 1 78  GLN 78  78  78  GLN GLN A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  MET 84  84  84  MET MET A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  PRO 86  86  86  PRO PRO A . n 
A 1 87  THR 87  87  87  THR THR A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  TYR 90  90  90  TYR TYR A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  GLN 93  93  93  GLN GLN A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  MET 99  99  99  MET MET A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 ASP 105 105 105 ASP ASP A . n 
A 1 106 GLU 106 106 106 GLU GLU A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 CYS 108 108 108 CYS CYS A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 ILE 112 112 112 ILE ILE A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ALA 114 114 114 ALA ALA A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 GLU 120 120 120 GLU GLU A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 SER 125 125 125 SER SER A . n 
A 1 126 GLN 126 126 126 GLN GLN A . n 
A 1 127 THR 127 127 127 THR THR A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 GLN 129 129 129 GLN GLN A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 TYR 132 132 132 TYR TYR A . n 
A 1 133 GLY 133 133 133 GLY GLY A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 SER 135 135 135 SER SER A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 ASP 138 138 138 ASP ASP A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 ARG 141 141 141 ARG ARG A . n 
A 1 142 SER 142 142 142 SER SER A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 PHE 146 146 146 PHE PHE A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 PHE 148 148 148 PHE PHE A . n 
A 1 149 GLN 149 149 149 GLN GLN A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 GLY 158 158 158 GLY GLY A . n 
A 1 159 GLY 159 159 159 GLY GLY A . n 
A 1 160 ARG 160 160 160 ARG ARG A . n 
A 1 161 ASP 161 161 161 ASP ASP A . n 
A 1 162 GLU 162 162 162 GLU GLU A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ASN 164 164 164 ASN ASN A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 GLN 173 173 173 GLN GLN A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 TYR 179 179 179 TYR TYR A . n 
A 1 180 GLU 180 180 180 GLU GLU A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLY 182 182 182 GLY GLY A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 LYS 184 184 184 LYS LYS A . n 
A 1 185 LYS 185 185 185 LYS LYS A . n 
A 1 186 TRP 186 186 186 TRP TRP A . n 
A 1 187 GLY 187 187 187 GLY GLY A . n 
A 1 188 THR 188 188 188 THR THR A . n 
A 1 189 ASP 189 189 189 ASP ASP A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 LYS 192 192 192 LYS LYS A . n 
A 1 193 PHE 193 193 193 PHE PHE A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 LEU 197 197 197 LEU LEU A . n 
A 1 198 CYS 198 198 198 CYS CYS A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 ARG 200 200 200 ARG ARG A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 VAL 208 208 208 VAL VAL A . n 
A 1 209 PHE 209 209 209 PHE PHE A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLU 211 211 211 GLU GLU A . n 
A 1 212 TYR 212 212 212 TYR TYR A . n 
A 1 213 LYS 213 213 213 LYS LYS A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 GLN 217 217 217 GLN GLN A . n 
A 1 218 LYS 218 218 218 LYS LYS A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 ILE 220 220 220 ILE ILE A . n 
A 1 221 GLU 221 221 221 GLU GLU A . n 
A 1 222 GLN 222 222 222 GLN GLN A . n 
A 1 223 SER 223 223 223 SER SER A . n 
A 1 224 ILE 224 224 224 ILE ILE A . n 
A 1 225 LYS 225 225 225 LYS LYS A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 THR 228 228 228 THR THR A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 PHE 232 232 232 PHE PHE A . n 
A 1 233 GLU 233 233 233 GLU GLU A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 LYS 241 241 241 LYS LYS A . n 
A 1 242 CYS 242 242 242 CYS CYS A . n 
A 1 243 MET 243 243 243 MET MET A . n 
A 1 244 ARG 244 244 244 ARG ARG A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 LYS 246 246 246 LYS LYS A . n 
A 1 247 SER 247 247 247 SER SER A . n 
A 1 248 ALA 248 248 248 ALA ALA A . n 
A 1 249 TYR 249 249 249 TYR TYR A . n 
A 1 250 PHE 250 250 250 PHE PHE A . n 
A 1 251 ALA 251 251 251 ALA ALA A . n 
A 1 252 GLU 252 252 252 GLU GLU A . n 
A 1 253 LYS 253 253 253 LYS LYS A . n 
A 1 254 LEU 254 254 254 LEU LEU A . n 
A 1 255 TYR 255 255 255 TYR TYR A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 MET 258 258 258 MET MET A . n 
A 1 259 LYS 259 259 259 LYS LYS A . n 
A 1 260 GLY 260 260 260 GLY GLY A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 GLY 262 262 262 GLY GLY A . n 
A 1 263 THR 263 263 263 THR THR A . n 
A 1 264 ASP 264 264 264 ASP ASP A . n 
A 1 265 ASP 265 265 265 ASP ASP A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 VAL 271 271 271 VAL VAL A . n 
A 1 272 MET 272 272 272 MET MET A . n 
A 1 273 VAL 273 273 273 VAL VAL A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 GLU 277 277 277 GLU GLU A . n 
A 1 278 ILE 278 278 278 ILE ILE A . n 
A 1 279 ASP 279 279 279 ASP ASP A . n 
A 1 280 MET 280 280 280 MET MET A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ILE 283 283 283 ILE ILE A . n 
A 1 284 ARG 284 284 284 ARG ARG A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 HIS 286 286 286 HIS HIS A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 ARG 289 289 289 ARG ARG A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 TYR 291 291 291 TYR TYR A . n 
A 1 292 GLY 292 292 292 GLY GLY A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 SER 297 297 297 SER SER A . n 
A 1 298 PHE 298 298 298 PHE PHE A . n 
A 1 299 ILE 299 299 299 ILE ILE A . n 
A 1 300 LYS 300 300 300 LYS LYS A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 ASP 302 302 302 ASP ASP A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 GLY 305 305 305 GLY GLY A . n 
A 1 306 ASP 306 306 306 ASP ASP A . n 
A 1 307 TYR 307 307 307 TYR TYR A . n 
A 1 308 ARG 308 308 308 ARG ARG A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 VAL 310 310 310 VAL VAL A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 CYS 315 315 315 CYS CYS A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 ?   ?   ?   A . n 
A 1 321 HIS 321 321 ?   ?   ?   A . n 
A 1 322 HIS 322 322 ?   ?   ?   A . n 
A 1 323 HIS 323 323 ?   ?   ?   A . n 
A 1 324 HIS 324 324 ?   ?   ?   A . n 
A 1 325 HIS 325 325 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CA  ? ? CA  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 SO4 ? ? SO4 ? ? 'SUBJECT OF INVESTIGATION' ? 
3 GOL ? ? GOL ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CA  1   401 1   CA  CA  A . 
C 2 CA  1   402 2   CA  CA  A . 
D 2 CA  1   403 4   CA  CA  A . 
E 3 GOL 1   404 306 GOL GOL A . 
F 3 GOL 1   405 307 GOL GOL A . 
G 3 GOL 1   406 308 GOL GOL A . 
H 4 SO4 1   407 239 SO4 SO4 A . 
I 4 SO4 1   408 240 SO4 SO4 A . 
J 4 SO4 1   409 241 SO4 SO4 A . 
K 4 SO4 1   410 242 SO4 SO4 A . 
L 4 SO4 1   411 243 SO4 SO4 A . 
M 4 SO4 1   412 244 SO4 SO4 A . 
N 5 HOH 1   501 316 HOH HOH A . 
N 5 HOH 2   502 82  HOH HOH A . 
N 5 HOH 3   503 273 HOH HOH A . 
N 5 HOH 4   504 87  HOH HOH A . 
N 5 HOH 5   505 352 HOH HOH A . 
N 5 HOH 6   506 323 HOH HOH A . 
N 5 HOH 7   507 118 HOH HOH A . 
N 5 HOH 8   508 246 HOH HOH A . 
N 5 HOH 9   509 334 HOH HOH A . 
N 5 HOH 10  510 79  HOH HOH A . 
N 5 HOH 11  511 366 HOH HOH A . 
N 5 HOH 12  512 115 HOH HOH A . 
N 5 HOH 13  513 138 HOH HOH A . 
N 5 HOH 14  514 265 HOH HOH A . 
N 5 HOH 15  515 188 HOH HOH A . 
N 5 HOH 16  516 269 HOH HOH A . 
N 5 HOH 17  517 261 HOH HOH A . 
N 5 HOH 18  518 56  HOH HOH A . 
N 5 HOH 19  519 139 HOH HOH A . 
N 5 HOH 20  520 150 HOH HOH A . 
N 5 HOH 21  521 101 HOH HOH A . 
N 5 HOH 22  522 297 HOH HOH A . 
N 5 HOH 23  523 174 HOH HOH A . 
N 5 HOH 24  524 194 HOH HOH A . 
N 5 HOH 25  525 32  HOH HOH A . 
N 5 HOH 26  526 247 HOH HOH A . 
N 5 HOH 27  527 220 HOH HOH A . 
N 5 HOH 28  528 307 HOH HOH A . 
N 5 HOH 29  529 125 HOH HOH A . 
N 5 HOH 30  530 271 HOH HOH A . 
N 5 HOH 31  531 93  HOH HOH A . 
N 5 HOH 32  532 12  HOH HOH A . 
N 5 HOH 33  533 177 HOH HOH A . 
N 5 HOH 34  534 61  HOH HOH A . 
N 5 HOH 35  535 223 HOH HOH A . 
N 5 HOH 36  536 372 HOH HOH A . 
N 5 HOH 37  537 302 HOH HOH A . 
N 5 HOH 38  538 84  HOH HOH A . 
N 5 HOH 39  539 248 HOH HOH A . 
N 5 HOH 40  540 63  HOH HOH A . 
N 5 HOH 41  541 58  HOH HOH A . 
N 5 HOH 42  542 74  HOH HOH A . 
N 5 HOH 43  543 93  HOH HOH A . 
N 5 HOH 44  544 48  HOH HOH A . 
N 5 HOH 45  545 137 HOH HOH A . 
N 5 HOH 46  546 146 HOH HOH A . 
N 5 HOH 47  547 16  HOH HOH A . 
N 5 HOH 48  548 293 HOH HOH A . 
N 5 HOH 49  549 244 HOH HOH A . 
N 5 HOH 50  550 242 HOH HOH A . 
N 5 HOH 51  551 3   HOH HOH A . 
N 5 HOH 52  552 164 HOH HOH A . 
N 5 HOH 53  553 112 HOH HOH A . 
N 5 HOH 54  554 75  HOH HOH A . 
N 5 HOH 55  555 81  HOH HOH A . 
N 5 HOH 56  556 120 HOH HOH A . 
N 5 HOH 57  557 8   HOH HOH A . 
N 5 HOH 58  558 5   HOH HOH A . 
N 5 HOH 59  559 298 HOH HOH A . 
N 5 HOH 60  560 27  HOH HOH A . 
N 5 HOH 61  561 170 HOH HOH A . 
N 5 HOH 62  562 106 HOH HOH A . 
N 5 HOH 63  563 321 HOH HOH A . 
N 5 HOH 64  564 78  HOH HOH A . 
N 5 HOH 65  565 126 HOH HOH A . 
N 5 HOH 66  566 328 HOH HOH A . 
N 5 HOH 67  567 237 HOH HOH A . 
N 5 HOH 68  568 10  HOH HOH A . 
N 5 HOH 69  569 181 HOH HOH A . 
N 5 HOH 70  570 153 HOH HOH A . 
N 5 HOH 71  571 38  HOH HOH A . 
N 5 HOH 72  572 251 HOH HOH A . 
N 5 HOH 73  573 109 HOH HOH A . 
N 5 HOH 74  574 240 HOH HOH A . 
N 5 HOH 75  575 179 HOH HOH A . 
N 5 HOH 76  576 13  HOH HOH A . 
N 5 HOH 77  577 113 HOH HOH A . 
N 5 HOH 78  578 184 HOH HOH A . 
N 5 HOH 79  579 107 HOH HOH A . 
N 5 HOH 80  580 108 HOH HOH A . 
N 5 HOH 81  581 5   HOH HOH A . 
N 5 HOH 82  582 368 HOH HOH A . 
N 5 HOH 83  583 94  HOH HOH A . 
N 5 HOH 84  584 40  HOH HOH A . 
N 5 HOH 85  585 128 HOH HOH A . 
N 5 HOH 86  586 31  HOH HOH A . 
N 5 HOH 87  587 103 HOH HOH A . 
N 5 HOH 88  588 33  HOH HOH A . 
N 5 HOH 89  589 142 HOH HOH A . 
N 5 HOH 90  590 289 HOH HOH A . 
N 5 HOH 91  591 123 HOH HOH A . 
N 5 HOH 92  592 263 HOH HOH A . 
N 5 HOH 93  593 25  HOH HOH A . 
N 5 HOH 94  594 66  HOH HOH A . 
N 5 HOH 95  595 111 HOH HOH A . 
N 5 HOH 96  596 60  HOH HOH A . 
N 5 HOH 97  597 132 HOH HOH A . 
N 5 HOH 98  598 90  HOH HOH A . 
N 5 HOH 99  599 234 HOH HOH A . 
N 5 HOH 100 600 30  HOH HOH A . 
N 5 HOH 101 601 11  HOH HOH A . 
N 5 HOH 102 602 19  HOH HOH A . 
N 5 HOH 103 603 306 HOH HOH A . 
N 5 HOH 104 604 70  HOH HOH A . 
N 5 HOH 105 605 245 HOH HOH A . 
N 5 HOH 106 606 35  HOH HOH A . 
N 5 HOH 107 607 167 HOH HOH A . 
N 5 HOH 108 608 152 HOH HOH A . 
N 5 HOH 109 609 103 HOH HOH A . 
N 5 HOH 110 610 89  HOH HOH A . 
N 5 HOH 111 611 160 HOH HOH A . 
N 5 HOH 112 612 88  HOH HOH A . 
N 5 HOH 113 613 97  HOH HOH A . 
N 5 HOH 114 614 2   HOH HOH A . 
N 5 HOH 115 615 377 HOH HOH A . 
N 5 HOH 116 616 20  HOH HOH A . 
N 5 HOH 117 617 71  HOH HOH A . 
N 5 HOH 118 618 98  HOH HOH A . 
N 5 HOH 119 619 28  HOH HOH A . 
N 5 HOH 120 620 91  HOH HOH A . 
N 5 HOH 121 621 6   HOH HOH A . 
N 5 HOH 122 622 332 HOH HOH A . 
N 5 HOH 123 623 43  HOH HOH A . 
N 5 HOH 124 624 180 HOH HOH A . 
N 5 HOH 125 625 314 HOH HOH A . 
N 5 HOH 126 626 75  HOH HOH A . 
N 5 HOH 127 627 4   HOH HOH A . 
N 5 HOH 128 628 45  HOH HOH A . 
N 5 HOH 129 629 345 HOH HOH A . 
N 5 HOH 130 630 67  HOH HOH A . 
N 5 HOH 131 631 50  HOH HOH A . 
N 5 HOH 132 632 9   HOH HOH A . 
N 5 HOH 133 633 171 HOH HOH A . 
N 5 HOH 134 634 51  HOH HOH A . 
N 5 HOH 135 635 185 HOH HOH A . 
N 5 HOH 136 636 18  HOH HOH A . 
N 5 HOH 137 637 258 HOH HOH A . 
N 5 HOH 138 638 373 HOH HOH A . 
N 5 HOH 139 639 135 HOH HOH A . 
N 5 HOH 140 640 124 HOH HOH A . 
N 5 HOH 141 641 349 HOH HOH A . 
N 5 HOH 142 642 259 HOH HOH A . 
N 5 HOH 143 643 375 HOH HOH A . 
N 5 HOH 144 644 254 HOH HOH A . 
N 5 HOH 145 645 47  HOH HOH A . 
N 5 HOH 146 646 76  HOH HOH A . 
N 5 HOH 147 647 7   HOH HOH A . 
N 5 HOH 148 648 163 HOH HOH A . 
N 5 HOH 149 649 86  HOH HOH A . 
N 5 HOH 150 650 351 HOH HOH A . 
N 5 HOH 151 651 15  HOH HOH A . 
N 5 HOH 152 652 157 HOH HOH A . 
N 5 HOH 153 653 148 HOH HOH A . 
N 5 HOH 154 654 225 HOH HOH A . 
N 5 HOH 155 655 34  HOH HOH A . 
N 5 HOH 156 656 39  HOH HOH A . 
N 5 HOH 157 657 376 HOH HOH A . 
N 5 HOH 158 658 221 HOH HOH A . 
N 5 HOH 159 659 300 HOH HOH A . 
N 5 HOH 160 660 69  HOH HOH A . 
N 5 HOH 161 661 24  HOH HOH A . 
N 5 HOH 162 662 136 HOH HOH A . 
N 5 HOH 163 663 190 HOH HOH A . 
N 5 HOH 164 664 92  HOH HOH A . 
N 5 HOH 165 665 49  HOH HOH A . 
N 5 HOH 166 666 14  HOH HOH A . 
N 5 HOH 167 667 161 HOH HOH A . 
N 5 HOH 168 668 159 HOH HOH A . 
N 5 HOH 169 669 102 HOH HOH A . 
N 5 HOH 170 670 222 HOH HOH A . 
N 5 HOH 171 671 83  HOH HOH A . 
N 5 HOH 172 672 253 HOH HOH A . 
N 5 HOH 173 673 110 HOH HOH A . 
N 5 HOH 174 674 249 HOH HOH A . 
N 5 HOH 175 675 318 HOH HOH A . 
N 5 HOH 176 676 227 HOH HOH A . 
N 5 HOH 177 677 182 HOH HOH A . 
N 5 HOH 178 678 162 HOH HOH A . 
N 5 HOH 179 679 362 HOH HOH A . 
N 5 HOH 180 680 369 HOH HOH A . 
N 5 HOH 181 681 17  HOH HOH A . 
N 5 HOH 182 682 42  HOH HOH A . 
N 5 HOH 183 683 176 HOH HOH A . 
N 5 HOH 184 684 131 HOH HOH A . 
N 5 HOH 185 685 343 HOH HOH A . 
N 5 HOH 186 686 59  HOH HOH A . 
N 5 HOH 187 687 168 HOH HOH A . 
N 5 HOH 188 688 12  HOH HOH A . 
N 5 HOH 189 689 172 HOH HOH A . 
N 5 HOH 190 690 85  HOH HOH A . 
N 5 HOH 191 691 46  HOH HOH A . 
N 5 HOH 192 692 241 HOH HOH A . 
N 5 HOH 193 693 64  HOH HOH A . 
N 5 HOH 194 694 309 HOH HOH A . 
N 5 HOH 195 695 130 HOH HOH A . 
N 5 HOH 196 696 230 HOH HOH A . 
N 5 HOH 197 697 212 HOH HOH A . 
N 5 HOH 198 698 310 HOH HOH A . 
N 5 HOH 199 699 99  HOH HOH A . 
N 5 HOH 200 700 235 HOH HOH A . 
N 5 HOH 201 701 44  HOH HOH A . 
N 5 HOH 202 702 77  HOH HOH A . 
N 5 HOH 203 703 279 HOH HOH A . 
N 5 HOH 204 704 102 HOH HOH A . 
N 5 HOH 205 705 266 HOH HOH A . 
N 5 HOH 206 706 121 HOH HOH A . 
N 5 HOH 207 707 73  HOH HOH A . 
N 5 HOH 208 708 36  HOH HOH A . 
N 5 HOH 209 709 37  HOH HOH A . 
N 5 HOH 210 710 133 HOH HOH A . 
N 5 HOH 211 711 100 HOH HOH A . 
N 5 HOH 212 712 192 HOH HOH A . 
N 5 HOH 213 713 55  HOH HOH A . 
N 5 HOH 214 714 95  HOH HOH A . 
N 5 HOH 215 715 80  HOH HOH A . 
N 5 HOH 216 716 175 HOH HOH A . 
N 5 HOH 217 717 281 HOH HOH A . 
N 5 HOH 218 718 189 HOH HOH A . 
N 5 HOH 219 719 72  HOH HOH A . 
N 5 HOH 220 720 57  HOH HOH A . 
N 5 HOH 221 721 52  HOH HOH A . 
N 5 HOH 222 722 156 HOH HOH A . 
N 5 HOH 223 723 252 HOH HOH A . 
N 5 HOH 224 724 59  HOH HOH A . 
N 5 HOH 225 725 371 HOH HOH A . 
N 5 HOH 226 726 268 HOH HOH A . 
N 5 HOH 227 727 363 HOH HOH A . 
N 5 HOH 228 728 68  HOH HOH A . 
N 5 HOH 229 729 21  HOH HOH A . 
N 5 HOH 230 730 34  HOH HOH A . 
N 5 HOH 231 731 166 HOH HOH A . 
N 5 HOH 232 732 356 HOH HOH A . 
N 5 HOH 233 733 65  HOH HOH A . 
N 5 HOH 234 734 303 HOH HOH A . 
N 5 HOH 235 735 333 HOH HOH A . 
N 5 HOH 236 736 155 HOH HOH A . 
N 5 HOH 237 737 165 HOH HOH A . 
N 5 HOH 238 738 191 HOH HOH A . 
N 5 HOH 239 739 53  HOH HOH A . 
N 5 HOH 240 740 70  HOH HOH A . 
N 5 HOH 241 741 154 HOH HOH A . 
N 5 HOH 242 742 169 HOH HOH A . 
N 5 HOH 243 743 257 HOH HOH A . 
N 5 HOH 244 744 357 HOH HOH A . 
N 5 HOH 245 745 62  HOH HOH A . 
N 5 HOH 246 746 149 HOH HOH A . 
N 5 HOH 247 747 201 HOH HOH A . 
N 5 HOH 248 748 129 HOH HOH A . 
N 5 HOH 249 749 340 HOH HOH A . 
N 5 HOH 250 750 370 HOH HOH A . 
N 5 HOH 251 751 183 HOH HOH A . 
N 5 HOH 252 752 209 HOH HOH A . 
N 5 HOH 253 753 141 HOH HOH A . 
N 5 HOH 254 754 354 HOH HOH A . 
N 5 HOH 255 755 238 HOH HOH A . 
N 5 HOH 256 756 147 HOH HOH A . 
N 5 HOH 257 757 228 HOH HOH A . 
N 5 HOH 258 758 276 HOH HOH A . 
N 5 HOH 259 759 229 HOH HOH A . 
N 5 HOH 260 760 217 HOH HOH A . 
N 5 HOH 261 761 262 HOH HOH A . 
N 5 HOH 262 762 236 HOH HOH A . 
N 5 HOH 263 763 205 HOH HOH A . 
N 5 HOH 264 764 256 HOH HOH A . 
N 5 HOH 265 765 208 HOH HOH A . 
N 5 HOH 266 766 304 HOH HOH A . 
N 5 HOH 267 767 195 HOH HOH A . 
N 5 HOH 268 768 202 HOH HOH A . 
N 5 HOH 269 769 313 HOH HOH A . 
N 5 HOH 270 770 267 HOH HOH A . 
N 5 HOH 271 771 374 HOH HOH A . 
N 5 HOH 272 772 226 HOH HOH A . 
N 5 HOH 273 773 214 HOH HOH A . 
N 5 HOH 274 774 207 HOH HOH A . 
N 5 HOH 275 775 219 HOH HOH A . 
N 5 HOH 276 776 200 HOH HOH A . 
N 5 HOH 277 777 199 HOH HOH A . 
N 5 HOH 278 778 210 HOH HOH A . 
N 5 HOH 279 779 327 HOH HOH A . 
N 5 HOH 280 780 330 HOH HOH A . 
N 5 HOH 281 781 355 HOH HOH A . 
N 5 HOH 282 782 213 HOH HOH A . 
N 5 HOH 283 783 277 HOH HOH A . 
N 5 HOH 284 784 224 HOH HOH A . 
N 5 HOH 285 785 239 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   93.910 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GA6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.742 
_cell.length_a_esd                 ? 
_cell.length_b                     39.906 
_cell.length_b_esd                 ? 
_cell.length_c                     73.456 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GA6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GA6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.36 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium acetate (pH 4.6), 0.2 M ammonium sulfate, and 25 % (v/v) PEG 4000.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-07-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.991874 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.991874 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9GA6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.27 
_reflns.d_resolution_low                               58.6 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     86437 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.089 
_reflns.pdbx_Rpim_I_all                                0.059 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.059 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.27 
_reflns_shell.d_res_low                                     1.29 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4117 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          91.7 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.6 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.002 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            0.002 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            0.000 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               11.972 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.967 
_refine.correlation_coeff_Fo_to_Fc_free          0.963 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GA6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.27 
_refine.ls_d_res_low                             58.6 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     86419 
_refine.ls_number_reflns_R_free                  4312 
_refine.ls_number_reflns_R_work                  82107 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.599 
_refine.ls_percent_reflns_R_free                 4.990 
_refine.ls_R_factor_all                          0.175 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.1891 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1739 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.046 
_refine.pdbx_overall_ESU_R_Free                  0.046 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             0.825 
_refine.overall_SU_ML                            0.034 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2499 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         51 
_refine_hist.number_atoms_solvent             285 
_refine_hist.number_atoms_total               2835 
_refine_hist.d_res_high                       1.27 
_refine_hist.d_res_low                        58.6 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.012  0.012  2592 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2477 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.896  1.835  3482 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.666  1.791  5706 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.039  5.000  326  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 7.840  5.000  24   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 11.381 10.000 494  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.851 10.000 122  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.093  0.200  392  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  3056 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  598  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.255  0.200  557  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.171  0.200  2152 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.185  0.200  1315 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.072  0.200  1405 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.124  0.200  168  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.055  0.200  9    ? r_metal_ion_refined            ? ? 
'X-RAY DIFFRACTION' ? 0.313  0.200  27   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.301  0.200  95   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.213  0.200  21   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 0.100  0.200  1    ? r_xyhbond_nbd_other            ? ? 
'X-RAY DIFFRACTION' ? 1.285  1.078  1280 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 1.252  1.079  1280 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 1.868  1.938  1602 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 1.877  1.940  1603 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 2.920  1.398  1312 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.774  1.371  1289 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.018  2.424  1876 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.974  2.374  1841 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 5.391  14.414 3086 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.355  12.646 3018 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.27  1.301 . . 325 5859 93.4139 . . . . 0.299 . . . . . . . . . . . 0.324 
'X-RAY DIFFRACTION' 1.301 1.336 . . 319 5867 95.0376 . . . . 0.294 . . . . . . . . . . . 0.312 
'X-RAY DIFFRACTION' 1.336 1.375 . . 288 5644 94.3684 . . . . 0.268 . . . . . . . . . . . 0.269 
'X-RAY DIFFRACTION' 1.375 1.417 . . 282 5696 97.5841 . . . . 0.244 . . . . . . . . . . . 0.244 
'X-RAY DIFFRACTION' 1.417 1.464 . . 233 5568 98.3054 . . . . 0.216 . . . . . . . . . . . 0.225 
'X-RAY DIFFRACTION' 1.464 1.515 . . 267 5383 98.1584 . . . . 0.181 . . . . . . . . . . . 0.186 
'X-RAY DIFFRACTION' 1.515 1.572 . . 324 5131 98.0762 . . . . 0.171 . . . . . . . . . . . 0.201 
'X-RAY DIFFRACTION' 1.572 1.636 . . 289 4668 93.0717 . . . . 0.164 . . . . . . . . . . . 0.183 
'X-RAY DIFFRACTION' 1.636 1.709 . . 253 4741 97.5391 . . . . 0.154 . . . . . . . . . . . 0.161 
'X-RAY DIFFRACTION' 1.709 1.792 . . 248 4546 97.6574 . . . . 0.156 . . . . . . . . . . . 0.167 
'X-RAY DIFFRACTION' 1.792 1.889 . . 180 4342 97.2892 . . . . 0.153 . . . . . . . . . . . 0.173 
'X-RAY DIFFRACTION' 1.889 2.004 . . 193 4099 96.9286 . . . . 0.155 . . . . . . . . . . . 0.178 
'X-RAY DIFFRACTION' 2.004 2.142 . . 225 3793 96.7261 . . . . 0.153 . . . . . . . . . . . 0.182 
'X-RAY DIFFRACTION' 2.142 2.313 . . 165 3468 93.2974 . . . . 0.144 . . . . . . . . . . . 0.165 
'X-RAY DIFFRACTION' 2.313 2.534 . . 196 3214 95.0920 . . . . 0.140 . . . . . . . . . . . 0.161 
'X-RAY DIFFRACTION' 2.534 2.832 . . 144 2904 93.7558 . . . . 0.154 . . . . . . . . . . . 0.189 
'X-RAY DIFFRACTION' 2.832 3.269 . . 150 2511 92.8148 . . . . 0.170 . . . . . . . . . . . 0.186 
'X-RAY DIFFRACTION' 3.269 4.001 . . 96  2102 90.1189 . . . . 0.157 . . . . . . . . . . . 0.134 
'X-RAY DIFFRACTION' 4.001 5.645 . . 91  1647 91.1379 . . . . 0.168 . . . . . . . . . . . 0.170 
'X-RAY DIFFRACTION' 5.645 58.6  . . 44  924  87.4435 . . . . 0.245 . . . . . . . . . . . 0.286 
# 
_struct.entry_id                     9GA6 
_struct.title                        'The crystal structure of human Annexin A4 derived from crystals grown in 40 mM of CaCl2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GA6 
_struct_keywords.text            'Calcium/phospholipid-binding protein, complex with calcium, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ANXA4_HUMAN 
_struct_ref.pdbx_db_accession          P09525 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVI
VGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDD
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9GA6 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 319 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P09525 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  319 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       319 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9GA6 HIS A 320 ? UNP P09525 ? ? 'expression tag' 320 1 
1 9GA6 HIS A 321 ? UNP P09525 ? ? 'expression tag' 321 2 
1 9GA6 HIS A 322 ? UNP P09525 ? ? 'expression tag' 322 3 
1 9GA6 HIS A 323 ? UNP P09525 ? ? 'expression tag' 323 4 
1 9GA6 HIS A 324 ? UNP P09525 ? ? 'expression tag' 324 5 
1 9GA6 HIS A 325 ? UNP P09525 ? ? 'expression tag' 325 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1690  ? 
1 MORE         -90   ? 
1 'SSA (A^2)'  15580 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                'Gel filtration coupled with LS (SEC-LS)' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 15  ? LYS A 28  ? ASN A 15  LYS A 28  1 ? 14 
HELX_P HELX_P2  AA2 ASP A 33  ? ALA A 42  ? ASP A 33  ALA A 42  1 ? 10 
HELX_P HELX_P3  AA3 ASN A 45  ? GLY A 61  ? ASN A 45  GLY A 61  1 ? 17 
HELX_P HELX_P4  AA4 ASP A 63  ? LEU A 72  ? ASP A 63  LEU A 72  1 ? 10 
HELX_P HELX_P5  AA5 SER A 73  ? THR A 85  ? SER A 73  THR A 85  1 ? 13 
HELX_P HELX_P6  AA6 PRO A 86  ? LYS A 100 ? PRO A 86  LYS A 100 1 ? 15 
HELX_P HELX_P7  AA7 ASP A 105 ? ARG A 116 ? ASP A 105 ARG A 116 1 ? 12 
HELX_P HELX_P8  AA8 THR A 117 ? GLY A 133 ? THR A 117 GLY A 133 1 ? 17 
HELX_P HELX_P9  AA9 SER A 135 ? THR A 144 ? SER A 135 THR A 144 1 ? 10 
HELX_P HELX_P10 AB1 SER A 145 ? GLY A 158 ? SER A 145 GLY A 158 1 ? 14 
HELX_P HELX_P11 AB2 ASP A 167 ? GLU A 183 ? ASP A 167 GLU A 183 1 ? 17 
HELX_P HELX_P12 AB3 ASP A 189 ? ARG A 200 ? ASP A 189 ARG A 200 1 ? 12 
HELX_P HELX_P13 AB4 ASN A 201 ? GLN A 217 ? ASN A 201 GLN A 217 1 ? 17 
HELX_P HELX_P14 AB5 ASP A 219 ? THR A 228 ? ASP A 219 THR A 228 1 ? 10 
HELX_P HELX_P15 AB6 SER A 229 ? ASN A 245 ? SER A 229 ASN A 245 1 ? 17 
HELX_P HELX_P16 AB7 ASN A 245 ? LYS A 259 ? ASN A 245 LYS A 259 1 ? 15 
HELX_P HELX_P17 AB8 ASP A 264 ? ALA A 276 ? ASP A 264 ALA A 276 1 ? 13 
HELX_P HELX_P18 AB9 ASP A 279 ? GLY A 292 ? ASP A 279 GLY A 292 1 ? 14 
HELX_P HELX_P19 AC1 SER A 294 ? THR A 303 ? SER A 294 THR A 303 1 ? 10 
HELX_P HELX_P20 AC2 SER A 304 ? GLY A 316 ? SER A 304 GLY A 316 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A MET 27  O   ? ? ? 1_555 B CA  . CA ? ? A MET 27  A CA  401 1_555 ? ? ? ? ? ? ? 2.311 ? ? 
metalc2  metalc ? ? A GLY 29  O   ? ? ? 1_555 B CA  . CA ? ? A GLY 29  A CA  401 1_555 ? ? ? ? ? ? ? 2.341 ? ? 
metalc3  metalc ? ? A GLY 31  O   ? ? ? 1_555 B CA  . CA ? ? A GLY 31  A CA  401 1_555 ? ? ? ? ? ? ? 2.409 ? ? 
metalc4  metalc ? ? A GLU 71  OE1 ? ? ? 1_555 B CA  . CA ? ? A GLU 71  A CA  401 1_555 ? ? ? ? ? ? ? 2.519 ? ? 
metalc5  metalc ? ? A GLU 71  OE2 ? ? ? 1_555 B CA  . CA ? ? A GLU 71  A CA  401 1_555 ? ? ? ? ? ? ? 2.469 ? ? 
metalc6  metalc ? ? A MET 99  O   ? ? ? 1_555 C CA  . CA ? ? A MET 99  A CA  402 1_555 ? ? ? ? ? ? ? 2.808 ? ? 
metalc7  metalc ? ? A GLY 101 O   ? ? ? 1_555 C CA  . CA ? ? A GLY 101 A CA  402 1_555 ? ? ? ? ? ? ? 2.815 ? ? 
metalc8  metalc ? ? A GLY 103 O   ? ? ? 1_555 C CA  . CA ? ? A GLY 103 A CA  402 1_555 ? ? ? ? ? ? ? 2.855 ? ? 
metalc9  metalc ? ? A THR 104 OG1 ? ? ? 1_555 C CA  . CA ? ? A THR 104 A CA  402 1_555 ? ? ? ? ? ? ? 3.043 ? ? 
metalc10 metalc ? ? A ASP 143 OD2 ? ? ? 1_555 C CA  . CA ? ? A ASP 143 A CA  402 1_555 ? ? ? ? ? ? ? 3.067 ? ? 
metalc11 metalc ? ? A MET 258 O   ? ? ? 1_555 D CA  . CA ? ? A MET 258 A CA  403 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc12 metalc ? ? A GLY 260 O   ? ? ? 1_555 D CA  . CA ? ? A GLY 260 A CA  403 1_555 ? ? ? ? ? ? ? 2.393 ? ? 
metalc13 metalc ? ? A GLY 262 O   ? ? ? 1_555 D CA  . CA ? ? A GLY 262 A CA  403 1_555 ? ? ? ? ? ? ? 2.416 ? ? 
metalc14 metalc ? ? A ASP 302 OD1 ? ? ? 1_555 D CA  . CA ? ? A ASP 302 A CA  403 1_555 ? ? ? ? ? ? ? 2.651 ? ? 
metalc15 metalc ? ? A ASP 302 OD2 ? ? ? 1_555 D CA  . CA ? ? A ASP 302 A CA  403 1_555 ? ? ? ? ? ? ? 2.765 ? ? 
metalc16 metalc ? ? B CA  .   CA  ? ? ? 1_555 N HOH . O  ? ? A CA  401 A HOH 699 1_555 ? ? ? ? ? ? ? 2.411 ? ? 
metalc17 metalc ? ? B CA  .   CA  ? ? ? 1_555 N HOH . O  ? ? A CA  401 A HOH 747 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc18 metalc ? ? C CA  .   CA  ? ? ? 1_555 N HOH . O  ? ? A CA  402 A HOH 666 1_545 ? ? ? ? ? ? ? 2.827 ? ? 
metalc19 metalc ? ? D CA  .   CA  ? ? ? 1_555 N HOH . O  ? ? A CA  403 A HOH 615 1_555 ? ? ? ? ? ? ? 2.616 ? ? 
metalc20 metalc ? ? D CA  .   CA  ? ? ? 1_555 N HOH . O  ? ? A CA  403 A HOH 727 1_555 ? ? ? ? ? ? ? 2.376 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 29  ? A GLY 29  ? 1_555 89.2  ? 
2  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 31  ? A GLY 31  ? 1_555 96.9  ? 
3  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? A GLY 31  ? A GLY 31  ? 1_555 81.9  ? 
4  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 84.5  ? 
5  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 157.9 ? 
6  O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 77.9  ? 
7  O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 81.5  ? 
8  O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 147.8 ? 
9  O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 129.6 ? 
10 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 51.7  ? 
11 O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 699 ? 1_555 95.8  ? 
12 O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 699 ? 1_555 76.3  ? 
13 O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 699 ? 1_555 154.6 ? 
14 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 699 ? 1_555 125.3 ? 
15 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 699 ? 1_555 74.1  ? 
16 O   ? A MET 27  ? A MET 27  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 167.6 ? 
17 O   ? A GLY 29  ? A GLY 29  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 103.0 ? 
18 O   ? A GLY 31  ? A GLY 31  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 86.8  ? 
19 OE1 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 84.7  ? 
20 OE2 ? A GLU 71  ? A GLU 71  ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 87.1  ? 
21 O   ? N HOH .   ? A HOH 699 ? 1_555 CA ? B CA . ? A CA 401 ? 1_555 O   ? N HOH .   ? A HOH 747 ? 1_555 85.5  ? 
22 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 101 ? A GLY 101 ? 1_555 79.6  ? 
23 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 103 ? A GLY 103 ? 1_555 91.3  ? 
24 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? A GLY 103 ? A GLY 103 ? 1_555 88.1  ? 
25 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OG1 ? A THR 104 ? A THR 104 ? 1_555 120.8 ? 
26 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OG1 ? A THR 104 ? A THR 104 ? 1_555 148.6 ? 
27 O   ? A GLY 103 ? A GLY 103 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OG1 ? A THR 104 ? A THR 104 ? 1_555 69.1  ? 
28 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 66.4  ? 
29 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 127.1 ? 
30 O   ? A GLY 103 ? A GLY 103 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 129.9 ? 
31 OG1 ? A THR 104 ? A THR 104 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 84.3  ? 
32 O   ? A MET 99  ? A MET 99  ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? N HOH .   ? A HOH 666 ? 1_545 144.8 ? 
33 O   ? A GLY 101 ? A GLY 101 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? N HOH .   ? A HOH 666 ? 1_545 99.6  ? 
34 O   ? A GLY 103 ? A GLY 103 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? N HOH .   ? A HOH 666 ? 1_545 123.9 ? 
35 OG1 ? A THR 104 ? A THR 104 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? N HOH .   ? A HOH 666 ? 1_545 77.4  ? 
36 OD2 ? A ASP 143 ? A ASP 143 ? 1_555 CA ? C CA . ? A CA 402 ? 1_555 O   ? N HOH .   ? A HOH 666 ? 1_545 88.0  ? 
37 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 260 ? A GLY 260 ? 1_555 87.7  ? 
38 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 262 ? A GLY 262 ? 1_555 104.0 ? 
39 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? A GLY 262 ? A GLY 262 ? 1_555 83.2  ? 
40 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 82.7  ? 
41 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 151.9 ? 
42 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 124.7 ? 
43 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 79.3  ? 
44 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 154.2 ? 
45 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 78.5  ? 
46 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 48.3  ? 
47 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 615 ? 1_555 176.3 ? 
48 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 615 ? 1_555 95.2  ? 
49 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 615 ? 1_555 78.6  ? 
50 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 615 ? 1_555 93.7  ? 
51 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 615 ? 1_555 98.8  ? 
52 O   ? A MET 258 ? A MET 258 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 96.8  ? 
53 O   ? A GLY 260 ? A GLY 260 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 81.2  ? 
54 O   ? A GLY 262 ? A GLY 262 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 153.4 ? 
55 OD1 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 73.9  ? 
56 OD2 ? A ASP 302 ? A ASP 302 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 122.2 ? 
57 O   ? N HOH .   ? A HOH 615 ? 1_555 CA ? D CA . ? A CA 403 ? 1_555 O   ? N HOH .   ? A HOH 727 ? 1_555 81.6  ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           317 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            317 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   ASP 
_struct_mon_prot_cis.pdbx_label_seq_id_2    318 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    ASP 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     318 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -21.40 
# 
_pdbx_entry_details.entry_id                   9GA6 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    318 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    501 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.11 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 24  ? ? CZ A ARG 24  ? ? NH2 A ARG 24  ? ? 115.83 120.30 -4.47 0.50 N 
2 1 NE A ARG 97  ? ? CZ A ARG 97  ? ? NH2 A ARG 97  ? ? 115.13 120.30 -5.17 0.50 N 
3 1 NE A ARG 122 ? ? CZ A ARG 122 ? ? NH2 A ARG 122 ? ? 116.57 120.30 -3.73 0.50 N 
4 1 NE A ARG 200 ? ? CZ A ARG 200 ? ? NH1 A ARG 200 ? ? 124.46 120.30 4.16  0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 146 ? ? 60.16   -144.07 
2 1 ASN A 245 ? ? -171.78 111.19  
3 1 ILE A 278 ? ? -97.16  -66.71  
4 1 ASP A 279 ? ? -146.75 24.65   
5 1 ASP A 318 ? ? -157.12 46.74   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1   ? A MET 1   
2 1 Y 1 A ALA 2   ? A ALA 2   
3 1 Y 1 A HIS 320 ? A HIS 320 
4 1 Y 1 A HIS 321 ? A HIS 321 
5 1 Y 1 A HIS 322 ? A HIS 322 
6 1 Y 1 A HIS 323 ? A HIS 323 
7 1 Y 1 A HIS 324 ? A HIS 324 
8 1 Y 1 A HIS 325 ? A HIS 325 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
GOL C1   C  N N 138 
GOL O1   O  N N 139 
GOL C2   C  N N 140 
GOL O2   O  N N 141 
GOL C3   C  N N 142 
GOL O3   O  N N 143 
GOL H11  H  N N 144 
GOL H12  H  N N 145 
GOL HO1  H  N N 146 
GOL H2   H  N N 147 
GOL HO2  H  N N 148 
GOL H31  H  N N 149 
GOL H32  H  N N 150 
GOL HO3  H  N N 151 
HIS N    N  N N 152 
HIS CA   C  N S 153 
HIS C    C  N N 154 
HIS O    O  N N 155 
HIS CB   C  N N 156 
HIS CG   C  Y N 157 
HIS ND1  N  Y N 158 
HIS CD2  C  Y N 159 
HIS CE1  C  Y N 160 
HIS NE2  N  Y N 161 
HIS OXT  O  N N 162 
HIS H    H  N N 163 
HIS H2   H  N N 164 
HIS HA   H  N N 165 
HIS HB2  H  N N 166 
HIS HB3  H  N N 167 
HIS HD1  H  N N 168 
HIS HD2  H  N N 169 
HIS HE1  H  N N 170 
HIS HE2  H  N N 171 
HIS HXT  H  N N 172 
HOH O    O  N N 173 
HOH H1   H  N N 174 
HOH H2   H  N N 175 
ILE N    N  N N 176 
ILE CA   C  N S 177 
ILE C    C  N N 178 
ILE O    O  N N 179 
ILE CB   C  N S 180 
ILE CG1  C  N N 181 
ILE CG2  C  N N 182 
ILE CD1  C  N N 183 
ILE OXT  O  N N 184 
ILE H    H  N N 185 
ILE H2   H  N N 186 
ILE HA   H  N N 187 
ILE HB   H  N N 188 
ILE HG12 H  N N 189 
ILE HG13 H  N N 190 
ILE HG21 H  N N 191 
ILE HG22 H  N N 192 
ILE HG23 H  N N 193 
ILE HD11 H  N N 194 
ILE HD12 H  N N 195 
ILE HD13 H  N N 196 
ILE HXT  H  N N 197 
LEU N    N  N N 198 
LEU CA   C  N S 199 
LEU C    C  N N 200 
LEU O    O  N N 201 
LEU CB   C  N N 202 
LEU CG   C  N N 203 
LEU CD1  C  N N 204 
LEU CD2  C  N N 205 
LEU OXT  O  N N 206 
LEU H    H  N N 207 
LEU H2   H  N N 208 
LEU HA   H  N N 209 
LEU HB2  H  N N 210 
LEU HB3  H  N N 211 
LEU HG   H  N N 212 
LEU HD11 H  N N 213 
LEU HD12 H  N N 214 
LEU HD13 H  N N 215 
LEU HD21 H  N N 216 
LEU HD22 H  N N 217 
LEU HD23 H  N N 218 
LEU HXT  H  N N 219 
LYS N    N  N N 220 
LYS CA   C  N S 221 
LYS C    C  N N 222 
LYS O    O  N N 223 
LYS CB   C  N N 224 
LYS CG   C  N N 225 
LYS CD   C  N N 226 
LYS CE   C  N N 227 
LYS NZ   N  N N 228 
LYS OXT  O  N N 229 
LYS H    H  N N 230 
LYS H2   H  N N 231 
LYS HA   H  N N 232 
LYS HB2  H  N N 233 
LYS HB3  H  N N 234 
LYS HG2  H  N N 235 
LYS HG3  H  N N 236 
LYS HD2  H  N N 237 
LYS HD3  H  N N 238 
LYS HE2  H  N N 239 
LYS HE3  H  N N 240 
LYS HZ1  H  N N 241 
LYS HZ2  H  N N 242 
LYS HZ3  H  N N 243 
LYS HXT  H  N N 244 
MET N    N  N N 245 
MET CA   C  N S 246 
MET C    C  N N 247 
MET O    O  N N 248 
MET CB   C  N N 249 
MET CG   C  N N 250 
MET SD   S  N N 251 
MET CE   C  N N 252 
MET OXT  O  N N 253 
MET H    H  N N 254 
MET H2   H  N N 255 
MET HA   H  N N 256 
MET HB2  H  N N 257 
MET HB3  H  N N 258 
MET HG2  H  N N 259 
MET HG3  H  N N 260 
MET HE1  H  N N 261 
MET HE2  H  N N 262 
MET HE3  H  N N 263 
MET HXT  H  N N 264 
PHE N    N  N N 265 
PHE CA   C  N S 266 
PHE C    C  N N 267 
PHE O    O  N N 268 
PHE CB   C  N N 269 
PHE CG   C  Y N 270 
PHE CD1  C  Y N 271 
PHE CD2  C  Y N 272 
PHE CE1  C  Y N 273 
PHE CE2  C  Y N 274 
PHE CZ   C  Y N 275 
PHE OXT  O  N N 276 
PHE H    H  N N 277 
PHE H2   H  N N 278 
PHE HA   H  N N 279 
PHE HB2  H  N N 280 
PHE HB3  H  N N 281 
PHE HD1  H  N N 282 
PHE HD2  H  N N 283 
PHE HE1  H  N N 284 
PHE HE2  H  N N 285 
PHE HZ   H  N N 286 
PHE HXT  H  N N 287 
PRO N    N  N N 288 
PRO CA   C  N S 289 
PRO C    C  N N 290 
PRO O    O  N N 291 
PRO CB   C  N N 292 
PRO CG   C  N N 293 
PRO CD   C  N N 294 
PRO OXT  O  N N 295 
PRO H    H  N N 296 
PRO HA   H  N N 297 
PRO HB2  H  N N 298 
PRO HB3  H  N N 299 
PRO HG2  H  N N 300 
PRO HG3  H  N N 301 
PRO HD2  H  N N 302 
PRO HD3  H  N N 303 
PRO HXT  H  N N 304 
SER N    N  N N 305 
SER CA   C  N S 306 
SER C    C  N N 307 
SER O    O  N N 308 
SER CB   C  N N 309 
SER OG   O  N N 310 
SER OXT  O  N N 311 
SER H    H  N N 312 
SER H2   H  N N 313 
SER HA   H  N N 314 
SER HB2  H  N N 315 
SER HB3  H  N N 316 
SER HG   H  N N 317 
SER HXT  H  N N 318 
SO4 S    S  N N 319 
SO4 O1   O  N N 320 
SO4 O2   O  N N 321 
SO4 O3   O  N N 322 
SO4 O4   O  N N 323 
THR N    N  N N 324 
THR CA   C  N S 325 
THR C    C  N N 326 
THR O    O  N N 327 
THR CB   C  N R 328 
THR OG1  O  N N 329 
THR CG2  C  N N 330 
THR OXT  O  N N 331 
THR H    H  N N 332 
THR H2   H  N N 333 
THR HA   H  N N 334 
THR HB   H  N N 335 
THR HG1  H  N N 336 
THR HG21 H  N N 337 
THR HG22 H  N N 338 
THR HG23 H  N N 339 
THR HXT  H  N N 340 
TRP N    N  N N 341 
TRP CA   C  N S 342 
TRP C    C  N N 343 
TRP O    O  N N 344 
TRP CB   C  N N 345 
TRP CG   C  Y N 346 
TRP CD1  C  Y N 347 
TRP CD2  C  Y N 348 
TRP NE1  N  Y N 349 
TRP CE2  C  Y N 350 
TRP CE3  C  Y N 351 
TRP CZ2  C  Y N 352 
TRP CZ3  C  Y N 353 
TRP CH2  C  Y N 354 
TRP OXT  O  N N 355 
TRP H    H  N N 356 
TRP H2   H  N N 357 
TRP HA   H  N N 358 
TRP HB2  H  N N 359 
TRP HB3  H  N N 360 
TRP HD1  H  N N 361 
TRP HE1  H  N N 362 
TRP HE3  H  N N 363 
TRP HZ2  H  N N 364 
TRP HZ3  H  N N 365 
TRP HH2  H  N N 366 
TRP HXT  H  N N 367 
TYR N    N  N N 368 
TYR CA   C  N S 369 
TYR C    C  N N 370 
TYR O    O  N N 371 
TYR CB   C  N N 372 
TYR CG   C  Y N 373 
TYR CD1  C  Y N 374 
TYR CD2  C  Y N 375 
TYR CE1  C  Y N 376 
TYR CE2  C  Y N 377 
TYR CZ   C  Y N 378 
TYR OH   O  N N 379 
TYR OXT  O  N N 380 
TYR H    H  N N 381 
TYR H2   H  N N 382 
TYR HA   H  N N 383 
TYR HB2  H  N N 384 
TYR HB3  H  N N 385 
TYR HD1  H  N N 386 
TYR HD2  H  N N 387 
TYR HE1  H  N N 388 
TYR HE2  H  N N 389 
TYR HH   H  N N 390 
TYR HXT  H  N N 391 
VAL N    N  N N 392 
VAL CA   C  N S 393 
VAL C    C  N N 394 
VAL O    O  N N 395 
VAL CB   C  N N 396 
VAL CG1  C  N N 397 
VAL CG2  C  N N 398 
VAL OXT  O  N N 399 
VAL H    H  N N 400 
VAL H2   H  N N 401 
VAL HA   H  N N 402 
VAL HB   H  N N 403 
VAL HG11 H  N N 404 
VAL HG12 H  N N 405 
VAL HG13 H  N N 406 
VAL HG21 H  N N 407 
VAL HG22 H  N N 408 
VAL HG23 H  N N 409 
VAL HXT  H  N N 410 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
SO4 S   O1   doub N N 303 
SO4 S   O2   doub N N 304 
SO4 S   O3   sing N N 305 
SO4 S   O4   sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2ZOC 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_related_exp_data_set.ordinal              1 
_pdbx_related_exp_data_set.data_reference       10.15151/ESRF-ES-771453717 
_pdbx_related_exp_data_set.metadata_reference   ? 
_pdbx_related_exp_data_set.data_set_type        'diffraction image data' 
_pdbx_related_exp_data_set.details              ? 
# 
_atom_sites.entry_id                    9GA6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017024 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001164 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.025059 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013645 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512  0.2156   
CA 20 20 8.6266  10.4421 7.3873 0.6599  1.5899 85.7484 1.0211 178.4370 1.6728   
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997  0.0030   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826   -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089  0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720  1.0532   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N   . THR A 1 3   ? 13.368  25.619  25.649  1.000 44.221 0 3   THR A N   1 ? 
ATOM   2    C  CA  . THR A 1 3   ? 13.446  26.969  26.251  1.000 39.821 0 3   THR A CA  1 ? 
ATOM   3    C  C   . THR A 1 3   ? 12.508  27.076  27.465  1.000 32.635 0 3   THR A C   1 ? 
ATOM   4    O  O   . THR A 1 3   ? 12.702  27.944  28.305  1.000 35.116 0 3   THR A O   1 ? 
ATOM   5    C  CB  . THR A 1 3   ? 13.143  28.042  25.205  1.000 39.745 0 3   THR A CB  1 ? 
ATOM   6    O  OG1 . THR A 1 3   ? 11.752  28.329  25.299  1.000 41.735 0 3   THR A OG1 1 ? 
ATOM   7    C  CG2 . THR A 1 3   ? 13.563  27.662  23.796  1.000 37.379 0 3   THR A CG2 1 ? 
ATOM   8    N  N   . LYS A 1 4   ? 11.464  26.244  27.583  1.000 24.428 0 4   LYS A N   1 ? 
ATOM   9    C  CA  . LYS A 1 4   ? 10.816  26.103  28.873  1.000 22.197 0 4   LYS A CA  1 ? 
ATOM   10   C  C   . LYS A 1 4   ? 11.538  25.035  29.708  1.000 18.652 0 4   LYS A C   1 ? 
ATOM   11   O  O   . LYS A 1 4   ? 11.524  25.116  30.933  1.000 20.134 0 4   LYS A O   1 ? 
ATOM   12   C  CB  . LYS A 1 4   ? 9.340   25.734  28.775  1.000 26.001 0 4   LYS A CB  1 ? 
ATOM   13   C  CG  . LYS A 1 4   ? 8.459   26.697  28.014  1.000 30.626 0 4   LYS A CG  1 ? 
ATOM   14   C  CD  . LYS A 1 4   ? 7.245   25.976  27.434  1.000 37.080 0 4   LYS A CD  1 ? 
ATOM   15   C  CE  . LYS A 1 4   ? 6.385   26.878  26.608  1.000 42.593 0 4   LYS A CE  1 ? 
ATOM   16   N  NZ  . LYS A 1 4   ? 5.919   27.936  27.509  1.000 46.856 0 4   LYS A NZ  1 ? 
ATOM   17   N  N   . GLY A 1 5   ? 12.102  23.999  29.054  1.000 16.270 0 5   GLY A N   1 ? 
ATOM   18   C  CA  . GLY A 1 5   ? 12.897  22.996  29.725  1.000 14.997 0 5   GLY A CA  1 ? 
ATOM   19   C  C   . GLY A 1 5   ? 12.076  21.792  30.235  1.000 12.961 0 5   GLY A C   1 ? 
ATOM   20   O  O   . GLY A 1 5   ? 11.029  21.454  29.678  1.000 14.147 0 5   GLY A O   1 ? 
ATOM   21   N  N   . GLY A 1 6   ? 12.576  21.129  31.247  1.000 12.208 0 6   GLY A N   1 ? 
ATOM   22   C  CA  . GLY A 1 6   ? 12.068  19.840  31.730  1.000 13.011 0 6   GLY A CA  1 ? 
ATOM   23   C  C   . GLY A 1 6   ? 11.001  19.962  32.811  1.000 12.376 0 6   GLY A C   1 ? 
ATOM   24   O  O   . GLY A 1 6   ? 10.881  21.002  33.464  1.000 14.272 0 6   GLY A O   1 ? 
ATOM   25   N  N   . THR A 1 7   ? 10.251  18.875  33.006  1.000 11.340 0 7   THR A N   1 ? 
ATOM   26   C  CA  . THR A 1 7   ? 9.299   18.796  34.119  1.000 11.571 0 7   THR A CA  1 ? 
ATOM   27   C  C   . THR A 1 7   ? 9.982   18.331  35.396  1.000 12.345 0 7   THR A C   1 ? 
ATOM   28   O  O   . THR A 1 7   ? 9.744   18.860  36.470  1.000 14.623 0 7   THR A O   1 ? 
ATOM   29   C  CB  . THR A 1 7   ? 8.172   17.862  33.755  1.000 12.787 0 7   THR A CB  1 ? 
ATOM   30   O  OG1 . THR A 1 7   ? 8.756   16.680  33.275  1.000 16.859 0 7   THR A OG1 1 ? 
ATOM   31   C  CG2 . THR A 1 7   ? 7.360   18.401  32.606  1.000 10.351 0 7   THR A CG2 1 ? 
ATOM   32   N  N   . VAL A 1 8   ? 10.866  17.355  35.277  1.000 11.697 0 8   VAL A N   1 ? 
ATOM   33   C  CA  . VAL A 1 8   ? 11.572  16.797  36.442  1.000 11.844 0 8   VAL A CA  1 ? 
ATOM   34   C  C   . VAL A 1 8   ? 12.804  17.628  36.720  1.000 12.360 0 8   VAL A C   1 ? 
ATOM   35   O  O   . VAL A 1 8   ? 13.619  17.829  35.821  1.000 14.670 0 8   VAL A O   1 ? 
ATOM   36   C  CB  . VAL A 1 8   ? 11.923  15.318  36.211  1.000 11.560 0 8   VAL A CB  1 ? 
ATOM   37   C  CG1 . VAL A 1 8   ? 12.799  14.785  37.350  1.000 12.009 0 8   VAL A CG1 1 ? 
ATOM   38   C  CG2 . VAL A 1 8   ? 10.658  14.502  36.048  1.000 12.225 0 8   VAL A CG2 1 ? 
ATOM   39   N  N   . LYS A 1 9   ? 12.889  18.074  37.982  1.000 13.441 0 9   LYS A N   1 ? 
ATOM   40   C  CA  . LYS A 1 9   ? 13.975  18.892  38.478  1.000 15.816 0 9   LYS A CA  1 ? 
ATOM   41   C  C   . LYS A 1 9   ? 14.641  18.190  39.659  1.000 13.097 0 9   LYS A C   1 ? 
ATOM   42   O  O   . LYS A 1 9   ? 14.005  17.409  40.333  1.000 14.119 0 9   LYS A O   1 ? 
ATOM   43   C  CB  . LYS A 1 9   ? 13.374  20.198  39.020  1.000 20.402 0 9   LYS A CB  1 ? 
ATOM   44   C  CG  . LYS A 1 9   ? 12.610  20.992  37.963  1.000 25.288 0 9   LYS A CG  1 ? 
ATOM   45   C  CD  . LYS A 1 9   ? 13.549  21.658  36.975  1.000 25.695 0 9   LYS A CD  1 ? 
ATOM   46   C  CE  . LYS A 1 9   ? 12.812  22.563  36.025  1.000 28.988 0 9   LYS A CE  1 ? 
ATOM   47   N  NZ  . LYS A 1 9   ? 13.652  22.722  34.831  1.000 33.497 0 9   LYS A NZ  1 ? 
ATOM   48   N  N   . ALA A 1 10  ? 15.852  18.654  39.991  1.000 14.763 0 10  ALA A N   1 ? 
ATOM   49   C  CA  . ALA A 1 10  ? 16.452  18.272  41.259  1.000 13.656 0 10  ALA A CA  1 ? 
ATOM   50   C  C   . ALA A 1 10  ? 15.562  18.688  42.421  1.000 14.504 0 10  ALA A C   1 ? 
ATOM   51   O  O   . ALA A 1 10  ? 15.103  19.827  42.477  1.000 16.339 0 10  ALA A O   1 ? 
ATOM   52   C  CB  . ALA A 1 10  ? 17.805  18.922  41.424  1.000 15.140 0 10  ALA A CB  1 ? 
ATOM   53   N  N   . ALA A 1 11  ? 15.358  17.780  43.367  1.000 12.075 0 11  ALA A N   1 ? 
ATOM   54   C  CA  . ALA A 1 11  ? 14.572  18.062  44.557  1.000 11.472 0 11  ALA A CA  1 ? 
ATOM   55   C  C   . ALA A 1 11  ? 15.384  18.928  45.514  1.000 12.131 0 11  ALA A C   1 ? 
ATOM   56   O  O   . ALA A 1 11  ? 16.580  18.726  45.669  1.000 13.573 0 11  ALA A O   1 ? 
ATOM   57   C  CB  . ALA A 1 11  ? 14.175  16.794  45.274  1.000 12.243 0 11  ALA A CB  1 ? 
ATOM   58   N  N   . SER A 1 12  ? 14.672  19.831  46.200  1.000 13.091 0 12  SER A N   1 ? 
ATOM   59   C  CA  . SER A 1 12  ? 15.187  20.497  47.379  1.000 14.564 0 12  SER A CA  1 ? 
ATOM   60   C  C   . SER A 1 12  ? 15.007  19.553  48.570  1.000 14.071 0 12  SER A C   1 ? 
ATOM   61   O  O   . SER A 1 12  ? 14.202  18.625  48.570  1.000 14.499 0 12  SER A O   1 ? 
ATOM   62   C  CB  . SER A 1 12  ? 14.484  21.835  47.633  1.000 17.179 0 12  SER A CB  1 ? 
ATOM   63   O  OG  . SER A 1 12  ? 13.093  21.611  47.762  1.000 25.578 0 12  SER A OG  1 ? 
ATOM   64   N  N   . GLY A 1 13  ? 15.710  19.820  49.631  1.000 14.312 0 13  GLY A N   1 ? 
ATOM   65   C  CA  . GLY A 1 13  ? 15.624  19.024  50.830  1.000 12.441 0 13  GLY A CA  1 ? 
ATOM   66   C  C   . GLY A 1 13  ? 15.967  17.561  50.609  1.000 11.745 0 13  GLY A C   1 ? 
ATOM   67   O  O   . GLY A 1 13  ? 15.545  16.762  51.415  1.000 13.118 0 13  GLY A O   1 ? 
ATOM   68   N  N   . PHE A 1 14  ? 16.749  17.249  49.584  1.000 11.391 0 14  PHE A N   1 ? 
ATOM   69   C  CA  . PHE A 1 14  ? 17.019  15.848  49.209  1.000 9.764  0 14  PHE A CA  1 ? 
ATOM   70   C  C   . PHE A 1 14  ? 17.794  15.131  50.307  1.000 9.794  0 14  PHE A C   1 ? 
ATOM   71   O  O   . PHE A 1 14  ? 18.860  15.586  50.722  1.000 10.511 0 14  PHE A O   1 ? 
ATOM   72   C  CB  . PHE A 1 14  ? 17.854  15.799  47.935  1.000 9.237  0 14  PHE A CB  1 ? 
ATOM   73   C  CG  . PHE A 1 14  ? 18.340  14.447  47.460  1.000 9.188  0 14  PHE A CG  1 ? 
ATOM   74   C  CD1 . PHE A 1 14  ? 17.544  13.302  47.573  1.000 9.038  0 14  PHE A CD1 1 ? 
ATOM   75   C  CD2 . PHE A 1 14  ? 19.586  14.344  46.828  1.000 8.284  0 14  PHE A CD2 1 ? 
ATOM   76   C  CE1 . PHE A 1 14  ? 18.017  12.098  47.175  1.000 8.760  0 14  PHE A CE1 1 ? 
ATOM   77   C  CE2 . PHE A 1 14  ? 20.048  13.131  46.408  1.000 9.225  0 14  PHE A CE2 1 ? 
ATOM   78   C  CZ  . PHE A 1 14  ? 19.283  12.011  46.618  1.000 8.611  0 14  PHE A CZ  1 ? 
ATOM   79   N  N   . ASN A 1 15  ? 17.232  14.021  50.819  1.000 9.068  0 15  ASN A N   1 ? 
ATOM   80   C  CA  . ASN A 1 15  ? 17.856  13.228  51.866  1.000 10.187 0 15  ASN A CA  1 ? 
ATOM   81   C  C   . ASN A 1 15  ? 17.863  11.788  51.356  1.000 8.552  0 15  ASN A C   1 ? 
ATOM   82   O  O   . ASN A 1 15  ? 16.824  11.135  51.375  1.000 8.263  0 15  ASN A O   1 ? 
ATOM   83   C  CB  . ASN A 1 15  ? 17.145  13.371  53.197  1.000 11.687 0 15  ASN A CB  1 ? 
ATOM   84   C  CG  . ASN A 1 15  ? 17.976  12.725  54.278  1.000 13.792 0 15  ASN A CG  1 ? 
ATOM   85   O  OD1 . ASN A 1 15  ? 18.248  11.539  54.247  1.000 13.669 0 15  ASN A OD1 1 ? 
ATOM   86   N  ND2 . ASN A 1 15  ? 18.696  13.532  55.065  1.000 20.461 0 15  ASN A ND2 1 ? 
ATOM   87   N  N   . ALA A 1 16  ? 19.019  11.343  50.876  1.000 8.833  0 16  ALA A N   1 ? 
ATOM   88   C  CA  . ALA A 1 16  ? 19.118  10.022  50.228  1.000 8.599  0 16  ALA A CA  1 ? 
ATOM   89   C  C   . ALA A 1 16  ? 18.867  8.899   51.218  1.000 9.460  0 16  ALA A C   1 ? 
ATOM   90   O  O   . ALA A 1 16  ? 18.261  7.885   50.829  1.000 8.683  0 16  ALA A O   1 ? 
ATOM   91   C  CB  . ALA A 1 16  ? 20.476  9.892   49.587  1.000 8.614  0 16  ALA A CB  1 ? 
ATOM   92   N  N   A MET A 1 17  ? 19.343  9.037   52.463  0.500 8.845  0 17  MET A N   1 ? 
ATOM   93   N  N   B MET A 1 17  ? 19.368  9.042   52.452  0.500 9.162  0 17  MET A N   1 ? 
ATOM   94   C  CA  A MET A 1 17  ? 19.103  7.973   53.438  0.500 9.565  0 17  MET A CA  1 ? 
ATOM   95   C  CA  B MET A 1 17  ? 19.124  8.017   53.466  0.500 10.329 0 17  MET A CA  1 ? 
ATOM   96   C  C   A MET A 1 17  ? 17.606  7.851   53.778  0.500 9.182  0 17  MET A C   1 ? 
ATOM   97   C  C   B MET A 1 17  ? 17.620  7.858   53.744  0.500 9.629  0 17  MET A C   1 ? 
ATOM   98   O  O   A MET A 1 17  ? 17.069  6.739   53.908  0.500 9.409  0 17  MET A O   1 ? 
ATOM   99   O  O   B MET A 1 17  ? 17.108  6.727   53.785  0.500 10.157 0 17  MET A O   1 ? 
ATOM   100  C  CB  A MET A 1 17  ? 19.914  8.192   54.717  0.500 10.397 0 17  MET A CB  1 ? 
ATOM   101  C  CB  B MET A 1 17  ? 19.856  8.348   54.770  0.500 11.817 0 17  MET A CB  1 ? 
ATOM   102  C  CG  A MET A 1 17  ? 20.065  6.938   55.535  0.500 11.117 0 17  MET A CG  1 ? 
ATOM   103  C  CG  B MET A 1 17  ? 19.589  7.378   55.889  0.500 13.454 0 17  MET A CG  1 ? 
ATOM   104  S  SD  A MET A 1 17  ? 21.165  7.186   56.933  0.500 13.779 0 17  MET A SD  1 ? 
ATOM   105  S  SD  B MET A 1 17  ? 20.648  7.660   57.319  0.500 17.782 0 17  MET A SD  1 ? 
ATOM   106  C  CE  A MET A 1 17  ? 22.373  8.002   55.966  0.500 9.941  0 17  MET A CE  1 ? 
ATOM   107  C  CE  B MET A 1 17  ? 20.644  5.981   57.966  0.500 12.972 0 17  MET A CE  1 ? 
ATOM   108  N  N   . GLU A 1 18  ? 16.894  8.973   53.904  1.000 8.687  0 18  GLU A N   1 ? 
ATOM   109  C  CA  . GLU A 1 18  ? 15.464  8.947   54.139  1.000 9.482  0 18  GLU A CA  1 ? 
ATOM   110  C  C   . GLU A 1 18  ? 14.773  8.286   52.937  1.000 8.889  0 18  GLU A C   1 ? 
ATOM   111  O  O   . GLU A 1 18  ? 13.882  7.458   53.102  1.000 8.543  0 18  GLU A O   1 ? 
ATOM   112  C  CB  . GLU A 1 18  ? 14.874  10.340  54.394  1.000 10.957 0 18  GLU A CB  1 ? 
ATOM   113  C  CG  . GLU A 1 18  ? 13.414  10.297  54.868  1.000 13.688 0 18  GLU A CG  1 ? 
ATOM   114  C  CD  . GLU A 1 18  ? 12.728  11.623  54.680  1.000 16.441 0 18  GLU A CD  1 ? 
ATOM   115  O  OE1 . GLU A 1 18  ? 12.829  12.446  55.591  1.000 19.347 0 18  GLU A OE1 1 ? 
ATOM   116  O  OE2 . GLU A 1 18  ? 12.115  11.848  53.604  1.000 17.539 0 18  GLU A OE2 1 ? 
ATOM   117  N  N   . ASP A 1 19  ? 15.120  8.702   51.714  1.000 8.243  0 19  ASP A N   1 ? 
ATOM   118  C  CA  . ASP A 1 19  ? 14.496  8.174   50.511  1.000 7.762  0 19  ASP A CA  1 ? 
ATOM   119  C  C   . ASP A 1 19  ? 14.717  6.673   50.422  1.000 7.468  0 19  ASP A C   1 ? 
ATOM   120  O  O   . ASP A 1 19  ? 13.816  5.919   50.063  1.000 7.737  0 19  ASP A O   1 ? 
ATOM   121  C  CB  . ASP A 1 19  ? 15.038  8.870   49.286  1.000 8.194  0 19  ASP A CB  1 ? 
ATOM   122  C  CG  . ASP A 1 19  ? 14.548  10.304  49.105  1.000 9.739  0 19  ASP A CG  1 ? 
ATOM   123  O  OD1 . ASP A 1 19  ? 13.583  10.700  49.710  1.000 10.845 0 19  ASP A OD1 1 ? 
ATOM   124  O  OD2 . ASP A 1 19  ? 15.145  10.957  48.268  1.000 10.121 0 19  ASP A OD2 1 ? 
ATOM   125  N  N   . ALA A 1 20  ? 15.919  6.208   50.755  1.000 7.090  0 20  ALA A N   1 ? 
ATOM   126  C  CA  . ALA A 1 20  ? 16.194  4.778   50.743  1.000 7.842  0 20  ALA A CA  1 ? 
ATOM   127  C  C   . ALA A 1 20  ? 15.268  4.064   51.714  1.000 8.743  0 20  ALA A C   1 ? 
ATOM   128  O  O   . ALA A 1 20  ? 14.742  2.981   51.426  1.000 8.506  0 20  ALA A O   1 ? 
ATOM   129  C  CB  . ALA A 1 20  ? 17.639  4.496   51.089  1.000 8.463  0 20  ALA A CB  1 ? 
ATOM   130  N  N   . GLN A 1 21  ? 15.099  4.610   52.920  1.000 8.672  0 21  GLN A N   1 ? 
ATOM   131  C  CA  . GLN A 1 21  ? 14.205  4.007   53.888  1.000 9.180  0 21  GLN A CA  1 ? 
ATOM   132  C  C   . GLN A 1 21  ? 12.759  4.020   53.407  1.000 8.669  0 21  GLN A C   1 ? 
ATOM   133  O  O   . GLN A 1 21  ? 12.058  3.054   53.626  1.000 8.828  0 21  GLN A O   1 ? 
ATOM   134  C  CB  . GLN A 1 21  ? 14.317  4.666   55.259  1.000 10.586 0 21  GLN A CB  1 ? 
ATOM   135  C  CG  . GLN A 1 21  ? 13.548  3.909   56.339  1.000 12.437 0 21  GLN A CG  1 ? 
ATOM   136  C  CD  . GLN A 1 21  ? 13.934  4.292   57.745  1.000 17.725 0 21  GLN A CD  1 ? 
ATOM   137  O  OE1 . GLN A 1 21  ? 14.338  5.426   58.023  1.000 19.477 0 21  GLN A OE1 1 ? 
ATOM   138  N  NE2 . GLN A 1 21  ? 13.720  3.339   58.650  1.000 20.172 0 21  GLN A NE2 1 ? 
ATOM   139  N  N   . THR A 1 22  ? 12.305  5.119   52.783  1.000 7.913  0 22  THR A N   1 ? 
ATOM   140  C  CA  . THR A 1 22  ? 10.945  5.196   52.256  1.000 7.883  0 22  THR A CA  1 ? 
ATOM   141  C  C   . THR A 1 22  ? 10.712  4.061   51.266  1.000 8.095  0 22  THR A C   1 ? 
ATOM   142  O  O   . THR A 1 22  ? 9.678   3.384   51.292  1.000 8.102  0 22  THR A O   1 ? 
ATOM   143  C  CB  . THR A 1 22  ? 10.733  6.564   51.636  1.000 8.704  0 22  THR A CB  1 ? 
ATOM   144  O  OG1 . THR A 1 22  ? 10.854  7.542   52.689  1.000 9.196  0 22  THR A OG1 1 ? 
ATOM   145  C  CG2 . THR A 1 22  ? 9.345   6.648   51.017  1.000 9.173  0 22  THR A CG2 1 ? 
ATOM   146  N  N   . LEU A 1 23  ? 11.687  3.845   50.367  1.000 7.594  0 23  LEU A N   1 ? 
ATOM   147  C  CA  . LEU A 1 23  ? 11.583  2.829   49.327  1.000 8.088  0 23  LEU A CA  1 ? 
ATOM   148  C  C   . LEU A 1 23  ? 11.572  1.435   49.968  1.000 8.206  0 23  LEU A C   1 ? 
ATOM   149  O  O   . LEU A 1 23  ? 10.748  0.572   49.585  1.000 8.165  0 23  LEU A O   1 ? 
ATOM   150  C  CB  . LEU A 1 23  ? 12.697  3.016   48.312  1.000 8.300  0 23  LEU A CB  1 ? 
ATOM   151  C  CG  . LEU A 1 23  ? 12.559  4.278   47.475  1.000 8.435  0 23  LEU A CG  1 ? 
ATOM   152  C  CD1 . LEU A 1 23  ? 13.826  4.594   46.721  1.000 10.066 0 23  LEU A CD1 1 ? 
ATOM   153  C  CD2 . LEU A 1 23  ? 11.408  4.168   46.466  1.000 9.523  0 23  LEU A CD2 1 ? 
ATOM   154  N  N   . ARG A 1 24  ? 12.466  1.189   50.945  1.000 8.034  0 24  ARG A N   1 ? 
ATOM   155  C  CA  . ARG A 1 24  ? 12.453  -0.097  51.624  1.000 8.751  0 24  ARG A CA  1 ? 
ATOM   156  C  C   . ARG A 1 24  ? 11.097  -0.338  52.284  1.000 8.872  0 24  ARG A C   1 ? 
ATOM   157  O  O   . ARG A 1 24  ? 10.570  -1.443  52.139  1.000 9.089  0 24  ARG A O   1 ? 
ATOM   158  C  CB  . ARG A 1 24  ? 13.646  -0.247  52.572  1.000 9.466  0 24  ARG A CB  1 ? 
ATOM   159  C  CG  . ARG A 1 24  ? 13.623  -1.474  53.481  1.000 10.009 0 24  ARG A CG  1 ? 
ATOM   160  C  CD  . ARG A 1 24  ? 13.663  -2.742  52.698  1.000 10.722 0 24  ARG A CD  1 ? 
ATOM   161  N  NE  . ARG A 1 24  ? 13.847  -3.872  53.614  1.000 10.660 0 24  ARG A NE  1 ? 
ATOM   162  C  CZ  . ARG A 1 24  ? 13.429  -5.095  53.397  1.000 11.183 0 24  ARG A CZ  1 ? 
ATOM   163  N  NH1 . ARG A 1 24  ? 12.911  -5.477  52.263  1.000 11.041 0 24  ARG A NH1 1 ? 
ATOM   164  N  NH2 . ARG A 1 24  ? 13.637  -5.969  54.393  1.000 12.630 0 24  ARG A NH2 1 ? 
ATOM   165  N  N   . LYS A 1 25  ? 10.597  0.634   53.028  1.000 8.802  0 25  LYS A N   1 ? 
ATOM   166  C  CA  . LYS A 1 25  ? 9.320   0.459   53.703  1.000 8.920  0 25  LYS A CA  1 ? 
ATOM   167  C  C   . LYS A 1 25  ? 8.207   0.197   52.702  1.000 9.015  0 25  LYS A C   1 ? 
ATOM   168  O  O   . LYS A 1 25  ? 7.337   -0.636  52.958  1.000 10.169 0 25  LYS A O   1 ? 
ATOM   169  C  CB  . LYS A 1 25  ? 8.938   1.709   54.498  1.000 10.467 0 25  LYS A CB  1 ? 
ATOM   170  C  CG  . LYS A 1 25  ? 9.812   1.938   55.761  1.000 15.732 0 25  LYS A CG  1 ? 
ATOM   171  C  CD  . LYS A 1 25  ? 9.354   1.118   56.948  1.000 21.286 0 25  LYS A CD  1 ? 
ATOM   172  C  CE  . LYS A 1 25  ? 10.086  1.589   58.169  1.000 23.126 0 25  LYS A CE  1 ? 
ATOM   173  N  NZ  . LYS A 1 25  ? 9.594   0.869   59.336  1.000 27.376 0 25  LYS A NZ  1 ? 
ATOM   174  N  N   . ALA A 1 26  ? 8.283   0.793   51.500  1.000 8.449  0 26  ALA A N   1 ? 
ATOM   175  C  CA  . ALA A 1 26  ? 7.258   0.589   50.479  1.000 8.972  0 26  ALA A CA  1 ? 
ATOM   176  C  C   . ALA A 1 26  ? 7.253   -0.855  49.982  1.000 8.584  0 26  ALA A C   1 ? 
ATOM   177  O  O   . ALA A 1 26  ? 6.186   -1.337  49.545  1.000 9.559  0 26  ALA A O   1 ? 
ATOM   178  C  CB  . ALA A 1 26  ? 7.488   1.544   49.320  1.000 8.664  0 26  ALA A CB  1 ? 
ATOM   179  N  N   . MET A 1 27  ? 8.388   -1.564  49.973  1.000 8.213  0 27  MET A N   1 ? 
ATOM   180  C  CA  . MET A 1 27  ? 8.537   -2.883  49.401  1.000 8.785  0 27  MET A CA  1 ? 
ATOM   181  C  C   . MET A 1 27  ? 8.553   -3.995  50.458  1.000 9.930  0 27  MET A C   1 ? 
ATOM   182  O  O   . MET A 1 27  ? 8.134   -5.107  50.130  1.000 10.149 0 27  MET A O   1 ? 
ATOM   183  C  CB  . MET A 1 27  ? 9.779   -2.958  48.522  1.000 8.458  0 27  MET A CB  1 ? 
ATOM   184  C  CG  . MET A 1 27  ? 9.685   -2.103  47.299  1.000 8.695  0 27  MET A CG  1 ? 
ATOM   185  S  SD  . MET A 1 27  ? 11.080  -2.162  46.174  1.000 10.135 0 27  MET A SD  1 ? 
ATOM   186  C  CE  . MET A 1 27  ? 12.178  -1.075  47.082  1.000 11.216 0 27  MET A CE  1 ? 
ATOM   187  N  N   . LYS A 1 28  ? 9.028   -3.724  51.672  1.000 9.692  0 28  LYS A N   1 ? 
ATOM   188  C  CA  . LYS A 1 28  ? 9.153   -4.782  52.677  1.000 10.582 0 28  LYS A CA  1 ? 
ATOM   189  C  C   . LYS A 1 28  ? 7.789   -5.404  52.969  1.000 11.831 0 28  LYS A C   1 ? 
ATOM   190  O  O   . LYS A 1 28  ? 6.829   -4.714  53.219  1.000 11.729 0 28  LYS A O   1 ? 
ATOM   191  C  CB  . LYS A 1 28  ? 9.783   -4.200  53.935  1.000 12.130 0 28  LYS A CB  1 ? 
ATOM   192  C  CG  . LYS A 1 28  ? 10.027  -5.242  55.002  1.000 13.218 0 28  LYS A CG  1 ? 
ATOM   193  C  CD  . LYS A 1 28  ? 10.809  -4.744  56.183  1.000 15.222 0 28  LYS A CD  1 ? 
ATOM   194  C  CE  . LYS A 1 28  ? 11.115  -5.874  57.120  1.000 19.062 0 28  LYS A CE  1 ? 
ATOM   195  N  NZ  . LYS A 1 28  ? 11.683  -5.343  58.349  1.000 20.653 0 28  LYS A NZ  1 ? 
ATOM   196  N  N   . GLY A 1 29  ? 7.769   -6.729  53.035  1.000 12.713 0 29  GLY A N   1 ? 
ATOM   197  C  CA  . GLY A 1 29  ? 6.549   -7.426  53.418  1.000 13.390 0 29  GLY A CA  1 ? 
ATOM   198  C  C   . GLY A 1 29  ? 5.690   -7.739  52.216  1.000 13.254 0 29  GLY A C   1 ? 
ATOM   199  O  O   . GLY A 1 29  ? 5.944   -7.333  51.087  1.000 13.388 0 29  GLY A O   1 ? 
ATOM   200  N  N   . LEU A 1 30  ? 4.601   -8.501  52.440  1.000 14.028 0 30  LEU A N   1 ? 
ATOM   201  C  CA  . LEU A 1 30  ? 3.695   -8.811  51.351  1.000 16.321 0 30  LEU A CA  1 ? 
ATOM   202  C  C   . LEU A 1 30  ? 3.194   -7.527  50.699  1.000 12.917 0 30  LEU A C   1 ? 
ATOM   203  O  O   . LEU A 1 30  ? 2.844   -6.562  51.365  1.000 12.849 0 30  LEU A O   1 ? 
ATOM   204  C  CB  . LEU A 1 30  ? 2.529   -9.636  51.897  1.000 19.118 0 30  LEU A CB  1 ? 
ATOM   205  C  CG  . LEU A 1 30  ? 1.512   -10.138 50.862  1.000 25.417 0 30  LEU A CG  1 ? 
ATOM   206  C  CD1 . LEU A 1 30  ? 2.072   -10.908 49.694  1.000 28.136 0 30  LEU A CD1 1 ? 
ATOM   207  C  CD2 . LEU A 1 30  ? 0.440   -10.972 51.555  1.000 28.788 0 30  LEU A CD2 1 ? 
ATOM   208  N  N   . GLY A 1 31  ? 3.217   -7.557  49.376  1.000 12.550 0 31  GLY A N   1 ? 
ATOM   209  C  CA  . GLY A 1 31  ? 2.733   -6.473  48.557  1.000 12.641 0 31  GLY A CA  1 ? 
ATOM   210  C  C   . GLY A 1 31  ? 3.700   -5.304  48.462  1.000 11.167 0 31  GLY A C   1 ? 
ATOM   211  O  O   . GLY A 1 31  ? 4.845   -5.429  48.882  1.000 11.563 0 31  GLY A O   1 ? 
ATOM   212  N  N   . THR A 1 32  ? 3.223   -4.202  47.909  1.000 10.439 0 32  THR A N   1 ? 
ATOM   213  C  CA  . THR A 1 32  ? 4.045   -3.045  47.596  1.000 9.111  0 32  THR A CA  1 ? 
ATOM   214  C  C   . THR A 1 32  ? 3.190   -1.797  47.745  1.000 9.602  0 32  THR A C   1 ? 
ATOM   215  O  O   . THR A 1 32  ? 1.993   -1.773  47.391  1.000 10.647 0 32  THR A O   1 ? 
ATOM   216  C  CB  . THR A 1 32  ? 4.469   -3.164  46.123  1.000 10.472 0 32  THR A CB  1 ? 
ATOM   217  O  OG1 . THR A 1 32  ? 4.983   -4.449  45.884  1.000 12.165 0 32  THR A OG1 1 ? 
ATOM   218  C  CG2 . THR A 1 32  ? 5.507   -2.126  45.731  1.000 9.999  0 32  THR A CG2 1 ? 
ATOM   219  N  N   . ASP A 1 33  ? 3.798   -0.687  48.158  1.000 9.346  0 33  ASP A N   1 ? 
ATOM   220  C  CA  . ASP A 1 33  ? 3.206   0.630   48.088  1.000 9.076  0 33  ASP A CA  1 ? 
ATOM   221  C  C   . ASP A 1 33  ? 3.757   1.336   46.843  1.000 9.769  0 33  ASP A C   1 ? 
ATOM   222  O  O   . ASP A 1 33  ? 4.718   2.098   46.936  1.000 9.115  0 33  ASP A O   1 ? 
ATOM   223  C  CB  . ASP A 1 33  ? 3.458   1.446   49.352  1.000 10.286 0 33  ASP A CB  1 ? 
ATOM   224  C  CG  . ASP A 1 33  ? 2.775   2.787   49.374  1.000 12.198 0 33  ASP A CG  1 ? 
ATOM   225  O  OD1 . ASP A 1 33  ? 2.181   3.185   48.356  1.000 12.555 0 33  ASP A OD1 1 ? 
ATOM   226  O  OD2 . ASP A 1 33  ? 2.863   3.433   50.468  1.000 15.343 0 33  ASP A OD2 1 ? 
ATOM   227  N  N   . GLU A 1 34  ? 3.145   1.127   45.672  1.000 9.854  0 34  GLU A N   1 ? 
ATOM   228  C  CA  . GLU A 1 34  ? 3.633   1.702   44.411  1.000 10.388 0 34  GLU A CA  1 ? 
ATOM   229  C  C   . GLU A 1 34  ? 3.562   3.221   44.469  1.000 10.830 0 34  GLU A C   1 ? 
ATOM   230  O  O   . GLU A 1 34  ? 4.438   3.924   43.927  1.000 10.104 0 34  GLU A O   1 ? 
ATOM   231  C  CB  . GLU A 1 34  ? 2.883   1.155   43.189  1.000 11.064 0 34  GLU A CB  1 ? 
ATOM   232  C  CG  . GLU A 1 34  ? 2.964   -0.349  43.034  1.000 11.566 0 34  GLU A CG  1 ? 
ATOM   233  C  CD  . GLU A 1 34  ? 1.906   -1.218  43.706  1.000 14.108 0 34  GLU A CD  1 ? 
ATOM   234  O  OE1 . GLU A 1 34  ? 1.103   -0.655  44.426  1.000 12.123 0 34  GLU A OE1 1 ? 
ATOM   235  O  OE2 . GLU A 1 34  ? 1.967   -2.450  43.509  1.000 16.284 0 34  GLU A OE2 1 ? 
ATOM   236  N  N   . ASP A 1 35  ? 2.511   3.778   45.092  1.000 11.262 0 35  ASP A N   1 ? 
ATOM   237  C  CA  . ASP A 1 35  ? 2.373   5.219   45.184  1.000 10.968 0 35  ASP A CA  1 ? 
ATOM   238  C  C   . ASP A 1 35  ? 3.570   5.837   45.884  1.000 10.195 0 35  ASP A C   1 ? 
ATOM   239  O  O   . ASP A 1 35  ? 4.043   6.895   45.489  1.000 11.167 0 35  ASP A O   1 ? 
ATOM   240  C  CB  . ASP A 1 35  ? 1.105   5.610   45.940  1.000 13.581 0 35  ASP A CB  1 ? 
ATOM   241  C  CG  . ASP A 1 35  ? -0.212  5.355   45.233  1.000 17.566 0 35  ASP A CG  1 ? 
ATOM   242  O  OD1 . ASP A 1 35  ? -0.247  5.269   44.000  1.000 19.604 0 35  ASP A OD1 1 ? 
ATOM   243  O  OD2 . ASP A 1 35  ? -1.203  5.202   45.989  1.000 23.711 0 35  ASP A OD2 1 ? 
ATOM   244  N  N   . ALA A 1 36  ? 4.027   5.188   46.948  1.000 9.725  0 36  ALA A N   1 ? 
ATOM   245  C  CA  . ALA A 1 36  ? 5.173   5.726   47.681  1.000 10.241 0 36  ALA A CA  1 ? 
ATOM   246  C  C   . ALA A 1 36  ? 6.443   5.707   46.825  1.000 9.498  0 36  ALA A C   1 ? 
ATOM   247  O  O   . ALA A 1 36  ? 7.279   6.615   46.862  1.000 10.131 0 36  ALA A O   1 ? 
ATOM   248  C  CB  . ALA A 1 36  ? 5.398   4.998   49.002  1.000 11.519 0 36  ALA A CB  1 ? 
ATOM   249  N  N   . ILE A 1 37  ? 6.624   4.638   46.042  1.000 8.833  0 37  ILE A N   1 ? 
ATOM   250  C  CA  . ILE A 1 37  ? 7.729   4.547   45.088  1.000 8.439  0 37  ILE A CA  1 ? 
ATOM   251  C  C   . ILE A 1 37  ? 7.715   5.706   44.093  1.000 9.011  0 37  ILE A C   1 ? 
ATOM   252  O  O   . ILE A 1 37  ? 8.723   6.388   43.874  1.000 10.066 0 37  ILE A O   1 ? 
ATOM   253  C  CB  . ILE A 1 37  ? 7.759   3.182   44.376  1.000 8.637  0 37  ILE A CB  1 ? 
ATOM   254  C  CG1 . ILE A 1 37  ? 8.028   2.102   45.394  1.000 8.811  0 37  ILE A CG1 1 ? 
ATOM   255  C  CG2 . ILE A 1 37  ? 8.811   3.156   43.250  1.000 9.334  0 37  ILE A CG2 1 ? 
ATOM   256  C  CD1 . ILE A 1 37  ? 7.861   0.683   44.860  1.000 8.720  0 37  ILE A CD1 1 ? 
ATOM   257  N  N   . ILE A 1 38  ? 6.550   6.040   43.522  1.000 7.696  0 38  ILE A N   1 ? 
ATOM   258  C  CA  . ILE A 1 38  ? 6.416   7.157   42.616  1.000 8.607  0 38  ILE A CA  1 ? 
ATOM   259  C  C   . ILE A 1 38  ? 6.749   8.454   43.337  1.000 8.588  0 38  ILE A C   1 ? 
ATOM   260  O  O   . ILE A 1 38  ? 7.438   9.304   42.784  1.000 8.857  0 38  ILE A O   1 ? 
ATOM   261  C  CB  . ILE A 1 38  ? 5.005   7.191   41.998  1.000 8.851  0 38  ILE A CB  1 ? 
ATOM   262  C  CG1 . ILE A 1 38  ? 4.766   5.953   41.154  1.000 8.999  0 38  ILE A CG1 1 ? 
ATOM   263  C  CG2 . ILE A 1 38  ? 4.807   8.439   41.140  1.000 9.646  0 38  ILE A CG2 1 ? 
ATOM   264  C  CD1 . ILE A 1 38  ? 3.290   5.806   40.748  1.000 9.994  0 38  ILE A CD1 1 ? 
ATOM   265  N  N   . SER A 1 39  ? 6.204   8.614   44.549  1.000 8.973  0 39  SER A N   1 ? 
ATOM   266  C  CA  A SER A 1 39  ? 6.288   9.847   45.334  0.500 9.196  0 39  SER A CA  1 ? 
ATOM   267  C  CA  B SER A 1 39  ? 6.296   9.875   45.274  0.500 9.969  0 39  SER A CA  1 ? 
ATOM   268  C  C   . SER A 1 39  ? 7.744   10.240  45.588  1.000 9.784  0 39  SER A C   1 ? 
ATOM   269  O  O   . SER A 1 39  ? 8.043   11.410  45.741  1.000 11.350 0 39  SER A O   1 ? 
ATOM   270  C  CB  A SER A 1 39  ? 5.553   9.690   46.687  0.500 9.833  0 39  SER A CB  1 ? 
ATOM   271  C  CB  B SER A 1 39  ? 5.461   9.816   46.537  0.500 12.355 0 39  SER A CB  1 ? 
ATOM   272  O  OG  A SER A 1 39  ? 6.323   8.974   47.625  0.500 11.563 0 39  SER A OG  1 ? 
ATOM   273  O  OG  B SER A 1 39  ? 4.107   10.002  46.132  0.500 15.782 0 39  SER A OG  1 ? 
ATOM   274  N  N   . VAL A 1 40  ? 8.631   9.231   45.683  1.000 9.182  0 40  VAL A N   1 ? 
ATOM   275  C  CA  . VAL A 1 40  ? 10.051  9.530   45.764  1.000 8.739  0 40  VAL A CA  1 ? 
ATOM   276  C  C   . VAL A 1 40  ? 10.621  9.691   44.355  1.000 8.596  0 40  VAL A C   1 ? 
ATOM   277  O  O   . VAL A 1 40  ? 11.119  10.729  43.958  1.000 9.026  0 40  VAL A O   1 ? 
ATOM   278  C  CB  . VAL A 1 40  ? 10.796  8.457   46.573  1.000 9.300  0 40  VAL A CB  1 ? 
ATOM   279  C  CG1 . VAL A 1 40  ? 12.304  8.684   46.489  1.000 9.217  0 40  VAL A CG1 1 ? 
ATOM   280  C  CG2 . VAL A 1 40  ? 10.265  8.380   48.006  1.000 9.975  0 40  VAL A CG2 1 ? 
ATOM   281  N  N   . LEU A 1 41  ? 10.588  8.601   43.561  1.000 8.140  0 41  LEU A N   1 ? 
ATOM   282  C  CA  . LEU A 1 41  ? 11.481  8.542   42.400  1.000 8.414  0 41  LEU A CA  1 ? 
ATOM   283  C  C   . LEU A 1 41  ? 11.117  9.509   41.282  1.000 8.818  0 41  LEU A C   1 ? 
ATOM   284  O  O   . LEU A 1 41  ? 11.988  10.008  40.562  1.000 9.209  0 41  LEU A O   1 ? 
ATOM   285  C  CB  . LEU A 1 41  ? 11.534  7.111   41.866  1.000 8.871  0 41  LEU A CB  1 ? 
ATOM   286  C  CG  . LEU A 1 41  ? 12.131  6.066   42.813  1.000 9.447  0 41  LEU A CG  1 ? 
ATOM   287  C  CD1 . LEU A 1 41  ? 12.089  4.701   42.107  1.000 10.110 0 41  LEU A CD1 1 ? 
ATOM   288  C  CD2 . LEU A 1 41  ? 13.529  6.426   43.247  1.000 9.950  0 41  LEU A CD2 1 ? 
ATOM   289  N  N   . ALA A 1 42  ? 9.824   9.799   41.120  1.000 8.619  0 42  ALA A N   1 ? 
ATOM   290  C  CA  . ALA A 1 42  ? 9.385   10.714  40.082  1.000 8.300  0 42  ALA A CA  1 ? 
ATOM   291  C  C   . ALA A 1 42  ? 9.602   12.173  40.464  1.000 8.420  0 42  ALA A C   1 ? 
ATOM   292  O  O   . ALA A 1 42  ? 9.400   13.041  39.622  1.000 10.212 0 42  ALA A O   1 ? 
ATOM   293  C  CB  . ALA A 1 42  ? 7.913   10.471  39.697  1.000 8.120  0 42  ALA A CB  1 ? 
ATOM   294  N  N   . TYR A 1 43  ? 10.065  12.422  41.697  1.000 8.335  0 43  TYR A N   1 ? 
ATOM   295  C  CA  . TYR A 1 43  ? 10.328  13.753  42.218  1.000 9.651  0 43  TYR A CA  1 ? 
ATOM   296  C  C   . TYR A 1 43  ? 11.791  13.918  42.599  1.000 9.670  0 43  TYR A C   1 ? 
ATOM   297  O  O   . TYR A 1 43  ? 12.137  14.853  43.349  1.000 9.855  0 43  TYR A O   1 ? 
ATOM   298  C  CB  . TYR A 1 43  ? 9.391   14.026  43.392  1.000 10.800 0 43  TYR A CB  1 ? 
ATOM   299  C  CG  . TYR A 1 43  ? 7.935   14.134  43.002  1.000 13.234 0 43  TYR A CG  1 ? 
ATOM   300  C  CD1 . TYR A 1 43  ? 7.419   15.313  42.516  1.000 14.699 0 43  TYR A CD1 1 ? 
ATOM   301  C  CD2 . TYR A 1 43  ? 7.134   13.021  43.011  1.000 12.451 0 43  TYR A CD2 1 ? 
ATOM   302  C  CE1 . TYR A 1 43  ? 6.087   15.404  42.109  1.000 15.196 0 43  TYR A CE1 1 ? 
ATOM   303  C  CE2 . TYR A 1 43  ? 5.804   13.086  42.629  1.000 14.123 0 43  TYR A CE2 1 ? 
ATOM   304  C  CZ  . TYR A 1 43  ? 5.294   14.279  42.211  1.000 14.345 0 43  TYR A CZ  1 ? 
ATOM   305  O  OH  . TYR A 1 43  ? 3.953   14.183  41.792  1.000 19.527 0 43  TYR A OH  1 ? 
ATOM   306  N  N   . ARG A 1 44  ? 12.648  13.125  41.961  1.000 8.470  0 44  ARG A N   1 ? 
ATOM   307  C  CA  . ARG A 1 44  ? 14.081  13.245  42.053  1.000 8.623  0 44  ARG A CA  1 ? 
ATOM   308  C  C   . ARG A 1 44  ? 14.614  13.196  40.636  1.000 8.656  0 44  ARG A C   1 ? 
ATOM   309  O  O   . ARG A 1 44  ? 14.032  12.504  39.772  1.000 10.695 0 44  ARG A O   1 ? 
ATOM   310  C  CB  . ARG A 1 44  ? 14.707  12.086  42.838  1.000 8.935  0 44  ARG A CB  1 ? 
ATOM   311  C  CG  . ARG A 1 44  ? 14.162  11.903  44.236  1.000 9.436  0 44  ARG A CG  1 ? 
ATOM   312  C  CD  . ARG A 1 44  ? 14.528  13.024  45.261  1.000 9.814  0 44  ARG A CD  1 ? 
ATOM   313  N  NE  . ARG A 1 44  ? 13.854  12.738  46.515  1.000 9.767  0 44  ARG A NE  1 ? 
ATOM   314  C  CZ  . ARG A 1 44  ? 12.609  12.984  46.849  1.000 9.068  0 44  ARG A CZ  1 ? 
ATOM   315  N  NH1 . ARG A 1 44  ? 11.847  13.766  46.108  1.000 9.691  0 44  ARG A NH1 1 ? 
ATOM   316  N  NH2 . ARG A 1 44  ? 12.096  12.494  47.947  1.000 9.548  0 44  ARG A NH2 1 ? 
ATOM   317  N  N   . ASN A 1 45  ? 15.743  13.872  40.340  1.000 8.593  0 45  ASN A N   1 ? 
ATOM   318  C  CA  . ASN A 1 45  ? 16.300  13.736  39.001  1.000 9.012  0 45  ASN A CA  1 ? 
ATOM   319  C  C   . ASN A 1 45  ? 17.164  12.464  38.903  1.000 8.007  0 45  ASN A C   1 ? 
ATOM   320  O  O   . ASN A 1 45  ? 17.367  11.742  39.872  1.000 7.786  0 45  ASN A O   1 ? 
ATOM   321  C  CB  . ASN A 1 45  ? 16.955  15.026  38.546  1.000 9.646  0 45  ASN A CB  1 ? 
ATOM   322  C  CG  . ASN A 1 45  ? 18.259  15.326  39.225  1.000 11.037 0 45  ASN A CG  1 ? 
ATOM   323  O  OD1 . ASN A 1 45  ? 18.748  14.528  40.011  1.000 10.637 0 45  ASN A OD1 1 ? 
ATOM   324  N  ND2 . ASN A 1 45  ? 18.835  16.479  38.931  1.000 11.712 0 45  ASN A ND2 1 ? 
ATOM   325  N  N   . THR A 1 46  ? 17.643  12.167  37.688  1.000 9.068  0 46  THR A N   1 ? 
ATOM   326  C  CA  . THR A 1 46  ? 18.364  10.929  37.453  1.000 8.726  0 46  THR A CA  1 ? 
ATOM   327  C  C   . THR A 1 46  ? 19.615  10.872  38.346  1.000 9.230  0 46  THR A C   1 ? 
ATOM   328  O  O   . THR A 1 46  ? 19.925  9.824   38.923  1.000 8.877  0 46  THR A O   1 ? 
ATOM   329  C  CB  . THR A 1 46  ? 18.696  10.724  35.978  1.000 10.714 0 46  THR A CB  1 ? 
ATOM   330  O  OG1 . THR A 1 46  ? 17.479  10.737  35.200  1.000 11.510 0 46  THR A OG1 1 ? 
ATOM   331  C  CG2 . THR A 1 46  ? 19.333  9.395   35.693  1.000 11.843 0 46  THR A CG2 1 ? 
ATOM   332  N  N   . ALA A 1 47  ? 20.346  11.988  38.449  1.000 8.602  0 47  ALA A N   1 ? 
ATOM   333  C  CA  . ALA A 1 47  ? 21.523  12.037  39.294  1.000 9.664  0 47  ALA A CA  1 ? 
ATOM   334  C  C   . ALA A 1 47  ? 21.166  11.724  40.737  1.000 8.348  0 47  ALA A C   1 ? 
ATOM   335  O  O   . ALA A 1 47  ? 21.838  10.936  41.433  1.000 8.926  0 47  ALA A O   1 ? 
ATOM   336  C  CB  . ALA A 1 47  ? 22.181  13.412  39.190  1.000 10.836 0 47  ALA A CB  1 ? 
ATOM   337  N  N   . GLN A 1 48  ? 20.097  12.325  41.241  1.000 8.182  0 48  GLN A N   1 ? 
ATOM   338  C  CA  . GLN A 1 48  ? 19.698  12.054  42.614  1.000 7.664  0 48  GLN A CA  1 ? 
ATOM   339  C  C   . GLN A 1 48  ? 19.265  10.605  42.810  1.000 7.643  0 48  GLN A C   1 ? 
ATOM   340  O  O   . GLN A 1 48  ? 19.525  10.021  43.862  1.000 8.123  0 48  GLN A O   1 ? 
ATOM   341  C  CB  . GLN A 1 48  ? 18.586  12.991  43.033  1.000 8.103  0 48  GLN A CB  1 ? 
ATOM   342  C  CG  . GLN A 1 48  ? 19.083  14.432  43.185  1.000 8.736  0 48  GLN A CG  1 ? 
ATOM   343  C  CD  . GLN A 1 48  ? 18.005  15.424  43.511  1.000 8.911  0 48  GLN A CD  1 ? 
ATOM   344  O  OE1 . GLN A 1 48  ? 16.846  15.294  43.098  1.000 10.301 0 48  GLN A OE1 1 ? 
ATOM   345  N  NE2 . GLN A 1 48  ? 18.317  16.442  44.310  1.000 9.796  0 48  GLN A NE2 1 ? 
ATOM   346  N  N   . ARG A 1 49  ? 18.627  10.020  41.807  1.000 7.275  0 49  ARG A N   1 ? 
ATOM   347  C  CA  . ARG A 1 49  ? 18.249  8.612   41.911  1.000 7.519  0 49  ARG A CA  1 ? 
ATOM   348  C  C   . ARG A 1 49  ? 19.491  7.717   42.071  1.000 7.548  0 49  ARG A C   1 ? 
ATOM   349  O  O   . ARG A 1 49  ? 19.416  6.690   42.763  1.000 7.705  0 49  ARG A O   1 ? 
ATOM   350  C  CB  . ARG A 1 49  ? 17.428  8.153   40.706  1.000 7.297  0 49  ARG A CB  1 ? 
ATOM   351  C  CG  . ARG A 1 49  ? 16.069  8.816   40.625  1.000 8.482  0 49  ARG A CG  1 ? 
ATOM   352  C  CD  . ARG A 1 49  ? 15.326  8.306   39.403  1.000 8.030  0 49  ARG A CD  1 ? 
ATOM   353  N  NE  . ARG A 1 49  ? 14.207  9.180   39.009  1.000 8.690  0 49  ARG A NE  1 ? 
ATOM   354  C  CZ  . ARG A 1 49  ? 14.115  9.819   37.859  1.000 8.807  0 49  ARG A CZ  1 ? 
ATOM   355  N  NH1 . ARG A 1 49  ? 14.875  9.519   36.821  1.000 8.531  0 49  ARG A NH1 1 ? 
ATOM   356  N  NH2 . ARG A 1 49  ? 13.153  10.736  37.723  1.000 9.723  0 49  ARG A NH2 1 ? 
ATOM   357  N  N   . GLN A 1 50  ? 20.628  8.076   41.464  1.000 8.006  0 50  GLN A N   1 ? 
ATOM   358  C  CA  . GLN A 1 50  ? 21.855  7.306   41.625  1.000 7.802  0 50  GLN A CA  1 ? 
ATOM   359  C  C   . GLN A 1 50  ? 22.374  7.429   43.058  1.000 7.564  0 50  GLN A C   1 ? 
ATOM   360  O  O   . GLN A 1 50  ? 22.885  6.463   43.619  1.000 8.310  0 50  GLN A O   1 ? 
ATOM   361  C  CB  . GLN A 1 50  ? 22.924  7.666   40.590  1.000 8.695  0 50  GLN A CB  1 ? 
ATOM   362  C  CG  . GLN A 1 50  ? 22.503  7.697   39.135  1.000 9.160  0 50  GLN A CG  1 ? 
ATOM   363  C  CD  . GLN A 1 50  ? 21.699  6.491   38.765  1.000 9.489  0 50  GLN A CD  1 ? 
ATOM   364  O  OE1 . GLN A 1 50  ? 20.533  6.576   38.285  1.000 13.642 0 50  GLN A OE1 1 ? 
ATOM   365  N  NE2 . GLN A 1 50  ? 22.260  5.343   38.968  1.000 8.440  0 50  GLN A NE2 1 ? 
ATOM   366  N  N   . GLU A 1 51  ? 22.252  8.618   43.670  1.000 7.289  0 51  GLU A N   1 ? 
ATOM   367  C  CA  . GLU A 1 51  ? 22.640  8.800   45.047  1.000 8.164  0 51  GLU A CA  1 ? 
ATOM   368  C  C   . GLU A 1 51  ? 21.759  7.945   45.957  1.000 7.744  0 51  GLU A C   1 ? 
ATOM   369  O  O   . GLU A 1 51  ? 22.211  7.376   46.966  1.000 8.667  0 51  GLU A O   1 ? 
ATOM   370  C  CB  . GLU A 1 51  ? 22.571  10.273  45.444  1.000 9.480  0 51  GLU A CB  1 ? 
ATOM   371  C  CG  . GLU A 1 51  ? 23.593  11.155  44.723  1.000 12.767 0 51  GLU A CG  1 ? 
ATOM   372  C  CD  . GLU A 1 51  ? 25.000  11.006  45.251  1.000 16.349 0 51  GLU A CD  1 ? 
ATOM   373  O  OE1 . GLU A 1 51  ? 25.173  10.498  46.360  1.000 20.224 0 51  GLU A OE1 1 ? 
ATOM   374  O  OE2 . GLU A 1 51  ? 25.903  11.454  44.530  1.000 24.508 0 51  GLU A OE2 1 ? 
ATOM   375  N  N   . ILE A 1 52  ? 20.458  7.819   45.619  1.000 7.798  0 52  ILE A N   1 ? 
ATOM   376  C  CA  . ILE A 1 52  ? 19.574  6.948   46.362  1.000 8.060  0 52  ILE A CA  1 ? 
ATOM   377  C  C   . ILE A 1 52  ? 20.032  5.498   46.226  1.000 8.077  0 52  ILE A C   1 ? 
ATOM   378  O  O   . ILE A 1 52  ? 20.005  4.749   47.216  1.000 8.255  0 52  ILE A O   1 ? 
ATOM   379  C  CB  . ILE A 1 52  ? 18.095  7.129   45.956  1.000 8.486  0 52  ILE A CB  1 ? 
ATOM   380  C  CG1 . ILE A 1 52  ? 17.603  8.507   46.277  1.000 7.855  0 52  ILE A CG1 1 ? 
ATOM   381  C  CG2 . ILE A 1 52  ? 17.223  6.104   46.676  1.000 8.792  0 52  ILE A CG2 1 ? 
ATOM   382  C  CD1 . ILE A 1 52  ? 16.293  8.879   45.621  1.000 9.107  0 52  ILE A CD1 1 ? 
ATOM   383  N  N   . ARG A 1 53  ? 20.362  5.044   45.014  1.000 8.135  0 53  ARG A N   1 ? 
ATOM   384  C  CA  . ARG A 1 53  ? 20.864  3.687   44.856  1.000 8.499  0 53  ARG A CA  1 ? 
ATOM   385  C  C   . ARG A 1 53  ? 22.034  3.418   45.794  1.000 8.520  0 53  ARG A C   1 ? 
ATOM   386  O  O   . ARG A 1 53  ? 22.115  2.351   46.420  1.000 9.242  0 53  ARG A O   1 ? 
ATOM   387  C  CB  . ARG A 1 53  ? 21.352  3.404   43.438  1.000 10.002 0 53  ARG A CB  1 ? 
ATOM   388  C  CG  . ARG A 1 53  ? 20.215  3.290   42.445  1.000 11.391 0 53  ARG A CG  1 ? 
ATOM   389  C  CD  . ARG A 1 53  ? 20.748  3.098   41.031  1.000 11.498 0 53  ARG A CD  1 ? 
ATOM   390  N  NE  . ARG A 1 53  ? 21.442  1.840   40.772  1.000 11.624 0 53  ARG A NE  1 ? 
ATOM   391  C  CZ  . ARG A 1 53  ? 22.004  1.504   39.618  1.000 14.200 0 53  ARG A CZ  1 ? 
ATOM   392  N  NH1 . ARG A 1 53  ? 22.223  2.401   38.701  1.000 15.973 0 53  ARG A NH1 1 ? 
ATOM   393  N  NH2 . ARG A 1 53  ? 22.412  0.296   39.386  1.000 14.664 0 53  ARG A NH2 1 ? 
ATOM   394  N  N   . THR A 1 54  ? 23.003  4.336   45.850  1.000 8.983  0 54  THR A N   1 ? 
ATOM   395  C  CA  . THR A 1 54  ? 24.194  4.169   46.691  1.000 8.630  0 54  THR A CA  1 ? 
ATOM   396  C  C   . THR A 1 54  ? 23.782  4.094   48.149  1.000 8.465  0 54  THR A C   1 ? 
ATOM   397  O  O   . THR A 1 54  ? 24.260  3.234   48.906  1.000 9.436  0 54  THR A O   1 ? 
ATOM   398  C  CB  . THR A 1 54  ? 25.173  5.306   46.397  1.000 10.126 0 54  THR A CB  1 ? 
ATOM   399  O  OG1 . THR A 1 54  ? 25.502  5.223   45.009  1.000 11.976 0 54  THR A OG1 1 ? 
ATOM   400  C  CG2 . THR A 1 54  ? 26.409  5.228   47.286  1.000 11.464 0 54  THR A CG2 1 ? 
ATOM   401  N  N   . ALA A 1 55  ? 22.917  5.010   48.611  1.000 7.951  0 55  ALA A N   1 ? 
ATOM   402  C  CA  . ALA A 1 55  ? 22.470  5.042   49.990  1.000 8.394  0 55  ALA A CA  1 ? 
ATOM   403  C  C   . ALA A 1 55  ? 21.666  3.789   50.336  1.000 8.899  0 55  ALA A C   1 ? 
ATOM   404  O  O   . ALA A 1 55  ? 21.712  3.349   51.498  1.000 8.927  0 55  ALA A O   1 ? 
ATOM   405  C  CB  . ALA A 1 55  ? 21.654  6.296   50.261  1.000 8.743  0 55  ALA A CB  1 ? 
ATOM   406  N  N   . TYR A 1 56  ? 20.925  3.227   49.380  1.000 8.344  0 56  TYR A N   1 ? 
ATOM   407  C  CA  . TYR A 1 56  ? 20.131  2.052   49.664  1.000 8.034  0 56  TYR A CA  1 ? 
ATOM   408  C  C   . TYR A 1 56  ? 21.087  0.887   49.939  1.000 7.775  0 56  TYR A C   1 ? 
ATOM   409  O  O   . TYR A 1 56  ? 20.913  0.130   50.907  1.000 8.858  0 56  TYR A O   1 ? 
ATOM   410  C  CB  . TYR A 1 56  ? 19.187  1.835   48.480  1.000 8.556  0 56  TYR A CB  1 ? 
ATOM   411  C  CG  . TYR A 1 56  ? 18.082  0.823   48.707  1.000 8.562  0 56  TYR A CG  1 ? 
ATOM   412  C  CD1 . TYR A 1 56  ? 16.830  1.235   49.155  1.000 8.471  0 56  TYR A CD1 1 ? 
ATOM   413  C  CD2 . TYR A 1 56  ? 18.252  -0.525  48.385  1.000 9.786  0 56  TYR A CD2 1 ? 
ATOM   414  C  CE1 . TYR A 1 56  ? 15.773  0.347   49.293  1.000 8.731  0 56  TYR A CE1 1 ? 
ATOM   415  C  CE2 . TYR A 1 56  ? 17.194  -1.425  48.500  1.000 9.088  0 56  TYR A CE2 1 ? 
ATOM   416  C  CZ  . TYR A 1 56  ? 15.975  -0.998  49.005  1.000 9.497  0 56  TYR A CZ  1 ? 
ATOM   417  O  OH  . TYR A 1 56  ? 14.896  -1.851  49.134  1.000 10.110 0 56  TYR A OH  1 ? 
ATOM   418  N  N   . LYS A 1 57  ? 22.108  0.744   49.102  1.000 8.308  0 57  LYS A N   1 ? 
ATOM   419  C  CA  . LYS A 1 57  ? 23.076  -0.316  49.353  1.000 9.874  0 57  LYS A CA  1 ? 
ATOM   420  C  C   . LYS A 1 57  ? 23.722  -0.096  50.708  1.000 10.416 0 57  LYS A C   1 ? 
ATOM   421  O  O   . LYS A 1 57  ? 23.841  -1.053  51.499  1.000 9.935  0 57  LYS A O   1 ? 
ATOM   422  C  CB  . LYS A 1 57  ? 24.142  -0.340  48.261  1.000 11.035 0 57  LYS A CB  1 ? 
ATOM   423  C  CG  . LYS A 1 57  ? 23.663  -0.939  46.965  1.000 14.651 0 57  LYS A CG  1 ? 
ATOM   424  C  CD  . LYS A 1 57  ? 24.587  -0.746  45.782  1.000 19.751 0 57  LYS A CD  1 ? 
ATOM   425  C  CE  . LYS A 1 57  ? 25.848  -1.384  45.949  1.000 24.634 0 57  LYS A CE  1 ? 
ATOM   426  N  NZ  . LYS A 1 57  ? 26.579  -1.190  44.687  1.000 29.576 0 57  LYS A NZ  1 ? 
ATOM   427  N  N   . SER A 1 58  ? 24.207  1.115   50.973  1.000 9.003  0 58  SER A N   1 ? 
ATOM   428  C  CA  . SER A 1 58  ? 25.004  1.385   52.180  1.000 10.727 0 58  SER A CA  1 ? 
ATOM   429  C  C   . SER A 1 58  ? 24.200  1.264   53.460  1.000 10.334 0 58  SER A C   1 ? 
ATOM   430  O  O   . SER A 1 58  ? 24.776  0.885   54.493  1.000 12.289 0 58  SER A O   1 ? 
ATOM   431  C  CB  . SER A 1 58  ? 25.585  2.793   52.093  1.000 12.508 0 58  SER A CB  1 ? 
ATOM   432  O  OG  . SER A 1 58  ? 26.552  2.831   51.075  1.000 20.270 0 58  SER A OG  1 ? 
ATOM   433  N  N   . THR A 1 59  ? 22.921  1.647   53.432  1.000 9.084  0 59  THR A N   1 ? 
ATOM   434  C  CA  . THR A 1 59  ? 22.137  1.823   54.631  1.000 9.816  0 59  THR A CA  1 ? 
ATOM   435  C  C   . THR A 1 59  ? 21.027  0.806   54.787  1.000 9.892  0 59  THR A C   1 ? 
ATOM   436  O  O   . THR A 1 59  ? 20.697  0.474   55.925  1.000 11.682 0 59  THR A O   1 ? 
ATOM   437  C  CB  . THR A 1 59  ? 21.606  3.236   54.854  1.000 10.785 0 59  THR A CB  1 ? 
ATOM   438  O  OG1 . THR A 1 59  ? 20.527  3.532   53.951  1.000 10.935 0 59  THR A OG1 1 ? 
ATOM   439  C  CG2 . THR A 1 59  ? 22.703  4.256   54.716  1.000 10.428 0 59  THR A CG2 1 ? 
ATOM   440  N  N   . ILE A 1 60  ? 20.516  0.236   53.689  1.000 9.371  0 60  ILE A N   1 ? 
ATOM   441  C  CA  . ILE A 1 60  ? 19.520  -0.835  53.765  1.000 9.583  0 60  ILE A CA  1 ? 
ATOM   442  C  C   . ILE A 1 60  ? 20.202  -2.185  53.593  1.000 9.423  0 60  ILE A C   1 ? 
ATOM   443  O  O   . ILE A 1 60  ? 19.657  -3.189  54.024  1.000 10.215 0 60  ILE A O   1 ? 
ATOM   444  C  CB  . ILE A 1 60  ? 18.385  -0.578  52.732  1.000 9.557  0 60  ILE A CB  1 ? 
ATOM   445  C  CG1 . ILE A 1 60  ? 17.807  0.849   52.835  1.000 9.875  0 60  ILE A CG1 1 ? 
ATOM   446  C  CG2 . ILE A 1 60  ? 17.289  -1.624  52.778  1.000 9.272  0 60  ILE A CG2 1 ? 
ATOM   447  C  CD1 . ILE A 1 60  ? 17.075  1.174   54.118  1.000 10.773 0 60  ILE A CD1 1 ? 
ATOM   448  N  N   . GLY A 1 61  ? 21.386  -2.230  52.990  1.000 9.519  0 61  GLY A N   1 ? 
ATOM   449  C  CA  . GLY A 1 61  ? 22.054  -3.515  52.853  1.000 9.643  0 61  GLY A CA  1 ? 
ATOM   450  C  C   . GLY A 1 61  ? 21.394  -4.399  51.792  1.000 9.568  0 61  GLY A C   1 ? 
ATOM   451  O  O   . GLY A 1 61  ? 21.521  -5.632  51.842  1.000 9.943  0 61  GLY A O   1 ? 
ATOM   452  N  N   . ARG A 1 62  ? 20.756  -3.767  50.805  1.000 9.182  0 62  ARG A N   1 ? 
ATOM   453  C  CA  . ARG A 1 62  ? 20.078  -4.442  49.691  1.000 8.832  0 62  ARG A CA  1 ? 
ATOM   454  C  C   . ARG A 1 62  ? 20.342  -3.648  48.415  1.000 9.069  0 62  ARG A C   1 ? 
ATOM   455  O  O   . ARG A 1 62  ? 20.902  -2.533  48.468  1.000 10.157 0 62  ARG A O   1 ? 
ATOM   456  C  CB  . ARG A 1 62  ? 18.578  -4.491  50.016  1.000 8.957  0 62  ARG A CB  1 ? 
ATOM   457  C  CG  . ARG A 1 62  ? 18.176  -5.245  51.277  1.000 8.886  0 62  ARG A CG  1 ? 
ATOM   458  C  CD  . ARG A 1 62  ? 16.647  -5.192  51.538  1.000 9.924  0 62  ARG A CD  1 ? 
ATOM   459  N  NE  . ARG A 1 62  ? 15.952  -5.911  50.487  1.000 10.370 0 62  ARG A NE  1 ? 
ATOM   460  C  CZ  . ARG A 1 62  ? 15.423  -7.106  50.640  1.000 12.366 0 62  ARG A CZ  1 ? 
ATOM   461  N  NH1 . ARG A 1 62  ? 15.572  -7.763  51.759  1.000 13.092 0 62  ARG A NH1 1 ? 
ATOM   462  N  NH2 . ARG A 1 62  ? 14.717  -7.638  49.666  1.000 12.761 0 62  ARG A NH2 1 ? 
ATOM   463  N  N   . ASP A 1 63  ? 19.941  -4.205  47.282  1.000 8.880  0 63  ASP A N   1 ? 
ATOM   464  C  CA  . ASP A 1 63  ? 20.122  -3.596  45.988  1.000 9.551  0 63  ASP A CA  1 ? 
ATOM   465  C  C   . ASP A 1 63  ? 18.781  -3.029  45.521  1.000 10.114 0 63  ASP A C   1 ? 
ATOM   466  O  O   . ASP A 1 63  ? 17.798  -3.780  45.372  1.000 9.992  0 63  ASP A O   1 ? 
ATOM   467  C  CB  . ASP A 1 63  ? 20.666  -4.568  44.952  1.000 12.727 0 63  ASP A CB  1 ? 
ATOM   468  C  CG  . ASP A 1 63  ? 20.998  -3.831  43.641  1.000 17.817 0 63  ASP A CG  1 ? 
ATOM   469  O  OD1 . ASP A 1 63  ? 20.104  -3.439  42.821  1.000 19.618 0 63  ASP A OD1 1 ? 
ATOM   470  O  OD2 . ASP A 1 63  ? 22.218  -3.581  43.399  1.000 25.149 0 63  ASP A OD2 1 ? 
ATOM   471  N  N   . LEU A 1 64  ? 18.699  -1.726  45.269  1.000 9.716  0 64  LEU A N   1 ? 
ATOM   472  C  CA  . LEU A 1 64  ? 17.426  -1.114  44.947  1.000 9.348  0 64  LEU A CA  1 ? 
ATOM   473  C  C   . LEU A 1 64  ? 16.846  -1.608  43.623  1.000 9.757  0 64  LEU A C   1 ? 
ATOM   474  O  O   . LEU A 1 64  ? 15.648  -1.849  43.528  1.000 9.034  0 64  LEU A O   1 ? 
ATOM   475  C  CB  . LEU A 1 64  ? 17.624  0.405   44.935  1.000 9.065  0 64  LEU A CB  1 ? 
ATOM   476  C  CG  . LEU A 1 64  ? 16.400  1.232   44.600  1.000 8.562  0 64  LEU A CG  1 ? 
ATOM   477  C  CD1 . LEU A 1 64  ? 15.198  0.904   45.446  1.000 8.686  0 64  LEU A CD1 1 ? 
ATOM   478  C  CD2 . LEU A 1 64  ? 16.757  2.692   44.765  1.000 8.786  0 64  LEU A CD2 1 ? 
ATOM   479  N  N   . ILE A 1 65  ? 17.643  -1.640  42.562  1.000 10.604 0 65  ILE A N   1 ? 
ATOM   480  C  CA  . ILE A 1 65  ? 17.123  -2.093  41.268  1.000 12.299 0 65  ILE A CA  1 ? 
ATOM   481  C  C   . ILE A 1 65  ? 16.610  -3.517  41.381  1.000 11.933 0 65  ILE A C   1 ? 
ATOM   482  O  O   . ILE A 1 65  ? 15.535  -3.791  40.857  1.000 11.343 0 65  ILE A O   1 ? 
ATOM   483  C  CB  . ILE A 1 65  ? 18.204  -2.035  40.180  1.000 15.940 0 65  ILE A CB  1 ? 
ATOM   484  C  CG1 . ILE A 1 65  ? 18.934  -0.766  40.197  1.000 20.792 0 65  ILE A CG1 1 ? 
ATOM   485  C  CG2 . ILE A 1 65  ? 17.615  -2.354  38.800  1.000 17.783 0 65  ILE A CG2 1 ? 
ATOM   486  C  CD1 . ILE A 1 65  ? 17.987  0.315   39.884  1.000 16.481 0 65  ILE A CD1 1 ? 
ATOM   487  N  N   . ASP A 1 66  ? 17.385  -4.380  42.013  1.000 12.342 0 66  ASP A N   1 ? 
ATOM   488  C  CA  . ASP A 1 66  ? 16.954  -5.768  42.165  1.000 12.110 0 66  ASP A CA  1 ? 
ATOM   489  C  C   . ASP A 1 66  ? 15.612  -5.837  42.894  1.000 10.630 0 66  ASP A C   1 ? 
ATOM   490  O  O   . ASP A 1 66  ? 14.712  -6.616  42.528  1.000 11.703 0 66  ASP A O   1 ? 
ATOM   491  C  CB  . ASP A 1 66  ? 18.003  -6.628  42.868  1.000 14.976 0 66  ASP A CB  1 ? 
ATOM   492  C  CG  . ASP A 1 66  ? 19.282  -6.903  42.087  1.000 19.874 0 66  ASP A CG  1 ? 
ATOM   493  O  OD1 . ASP A 1 66  ? 19.257  -6.709  40.872  1.000 24.200 0 66  ASP A OD1 1 ? 
ATOM   494  O  OD2 . ASP A 1 66  ? 20.279  -7.292  42.710  1.000 24.170 0 66  ASP A OD2 1 ? 
ATOM   495  N  N   . ASP A 1 67  ? 15.455  -5.072  43.986  1.000 9.542  0 67  ASP A N   1 ? 
ATOM   496  C  CA  . ASP A 1 67  ? 14.218  -5.068  44.750  1.000 10.145 0 67  ASP A CA  1 ? 
ATOM   497  C  C   . ASP A 1 67  ? 13.067  -4.549  43.892  1.000 9.633  0 67  ASP A C   1 ? 
ATOM   498  O  O   . ASP A 1 67  ? 11.981  -5.125  43.897  1.000 9.958  0 67  ASP A O   1 ? 
ATOM   499  C  CB  . ASP A 1 67  ? 14.360  -4.250  46.035  1.000 10.530 0 67  ASP A CB  1 ? 
ATOM   500  C  CG  . ASP A 1 67  ? 15.081  -4.943  47.181  1.000 11.835 0 67  ASP A CG  1 ? 
ATOM   501  O  OD1 . ASP A 1 67  ? 15.413  -6.177  47.014  1.000 14.830 0 67  ASP A OD1 1 ? 
ATOM   502  O  OD2 . ASP A 1 67  ? 15.244  -4.316  48.249  1.000 10.807 0 67  ASP A OD2 1 ? 
ATOM   503  N  N   . LEU A 1 68  ? 13.258  -3.466  43.142  1.000 9.447  0 68  LEU A N   1 ? 
ATOM   504  C  CA  . LEU A 1 68  ? 12.218  -2.910  42.280  1.000 9.016  0 68  LEU A CA  1 ? 
ATOM   505  C  C   . LEU A 1 68  ? 11.792  -3.966  41.264  1.000 11.302 0 68  LEU A C   1 ? 
ATOM   506  O  O   . LEU A 1 68  ? 10.598  -4.124  40.998  1.000 11.339 0 68  LEU A O   1 ? 
ATOM   507  C  CB  . LEU A 1 68  ? 12.674  -1.610  41.603  1.000 8.763  0 68  LEU A CB  1 ? 
ATOM   508  C  CG  . LEU A 1 68  ? 12.810  -0.419  42.562  1.000 8.937  0 68  LEU A CG  1 ? 
ATOM   509  C  CD1 . LEU A 1 68  ? 13.635  0.691   41.916  1.000 9.332  0 68  LEU A CD1 1 ? 
ATOM   510  C  CD2 . LEU A 1 68  ? 11.451  0.102   43.094  1.000 8.529  0 68  LEU A CD2 1 ? 
ATOM   511  N  N   . LYS A 1 69  ? 12.743  -4.666  40.661  1.000 10.162 0 69  LYS A N   1 ? 
ATOM   512  C  CA  . LYS A 1 69  ? 12.424  -5.671  39.631  1.000 11.424 0 69  LYS A CA  1 ? 
ATOM   513  C  C   . LYS A 1 69  ? 11.660  -6.826  40.246  1.000 12.468 0 69  LYS A C   1 ? 
ATOM   514  O  O   . LYS A 1 69  ? 10.744  -7.373  39.612  1.000 13.543 0 69  LYS A O   1 ? 
ATOM   515  C  CB  . LYS A 1 69  ? 13.713  -6.168  38.993  1.000 11.541 0 69  LYS A CB  1 ? 
ATOM   516  C  CG  . LYS A 1 69  ? 14.353  -5.224  38.028  1.000 12.864 0 69  LYS A CG  1 ? 
ATOM   517  C  CD  . LYS A 1 69  ? 15.694  -5.691  37.472  1.000 15.685 0 69  LYS A CD  1 ? 
ATOM   518  C  CE  . LYS A 1 69  ? 16.217  -4.775  36.396  1.000 19.533 0 69  LYS A CE  1 ? 
ATOM   519  N  NZ  . LYS A 1 69  ? 17.461  -5.300  35.815  1.000 24.402 0 69  LYS A NZ  1 ? 
ATOM   520  N  N   . SER A 1 70  ? 11.947  -7.182  41.484  1.000 11.878 0 70  SER A N   1 ? 
ATOM   521  C  CA  A SER A 1 70  ? 11.236  -8.246  42.176  0.500 12.903 0 70  SER A CA  1 ? 
ATOM   522  C  CA  B SER A 1 70  ? 11.240  -8.247  42.174  0.500 13.188 0 70  SER A CA  1 ? 
ATOM   523  C  C   . SER A 1 70  ? 9.815   -7.829  42.511  1.000 13.121 0 70  SER A C   1 ? 
ATOM   524  O  O   . SER A 1 70  ? 8.898   -8.654  42.467  1.000 15.673 0 70  SER A O   1 ? 
ATOM   525  C  CB  A SER A 1 70  ? 11.961  -8.657  43.445  0.500 13.116 0 70  SER A CB  1 ? 
ATOM   526  C  CB  B SER A 1 70  ? 12.015  -8.710  43.419  0.500 13.842 0 70  SER A CB  1 ? 
ATOM   527  O  OG  A SER A 1 70  ? 11.261  -9.687  44.140  0.500 14.065 0 70  SER A OG  1 ? 
ATOM   528  O  OG  B SER A 1 70  ? 11.923  -7.842  44.547  0.500 15.274 0 70  SER A OG  1 ? 
ATOM   529  N  N   . GLU A 1 71  ? 9.623   -6.586  42.910  1.000 10.643 0 71  GLU A N   1 ? 
ATOM   530  C  CA  . GLU A 1 71  ? 8.337   -6.141  43.426  1.000 10.726 0 71  GLU A CA  1 ? 
ATOM   531  C  C   . GLU A 1 71  ? 7.366   -5.676  42.339  1.000 11.025 0 71  GLU A C   1 ? 
ATOM   532  O  O   . GLU A 1 71  ? 6.161   -5.786  42.517  1.000 14.358 0 71  GLU A O   1 ? 
ATOM   533  C  CB  . GLU A 1 71  ? 8.578   -4.975  44.381  1.000 11.431 0 71  GLU A CB  1 ? 
ATOM   534  C  CG  . GLU A 1 71  ? 9.278   -5.427  45.642  1.000 12.016 0 71  GLU A CG  1 ? 
ATOM   535  C  CD  . GLU A 1 71  ? 8.397   -5.851  46.790  1.000 11.956 0 71  GLU A CD  1 ? 
ATOM   536  O  OE1 . GLU A 1 71  ? 7.299   -5.292  46.994  1.000 12.194 0 71  GLU A OE1 1 ? 
ATOM   537  O  OE2 . GLU A 1 71  ? 8.853   -6.710  47.550  1.000 13.485 0 71  GLU A OE2 1 ? 
ATOM   538  N  N   . LEU A 1 72  ? 7.871   -5.135  41.249  1.000 11.309 0 72  LEU A N   1 ? 
ATOM   539  C  CA  . LEU A 1 72  ? 7.067   -4.524  40.202  1.000 10.170 0 72  LEU A CA  1 ? 
ATOM   540  C  C   . LEU A 1 72  ? 6.962   -5.436  39.007  1.000 11.837 0 72  LEU A C   1 ? 
ATOM   541  O  O   . LEU A 1 72  ? 7.808   -6.289  38.818  1.000 14.425 0 72  LEU A O   1 ? 
ATOM   542  C  CB  . LEU A 1 72  ? 7.710   -3.187  39.807  1.000 10.031 0 72  LEU A CB  1 ? 
ATOM   543  C  CG  . LEU A 1 72  ? 7.926   -2.225  40.973  1.000 9.926  0 72  LEU A CG  1 ? 
ATOM   544  C  CD1 . LEU A 1 72  ? 8.434   -0.913  40.427  1.000 10.548 0 72  LEU A CD1 1 ? 
ATOM   545  C  CD2 . LEU A 1 72  ? 6.683   -1.993  41.794  1.000 10.401 0 72  LEU A CD2 1 ? 
ATOM   546  N  N   . SER A 1 73  ? 5.991   -5.156  38.131  1.000 11.922 0 73  SER A N   1 ? 
ATOM   547  C  CA  . SER A 1 73  ? 5.861   -5.869  36.869  1.000 12.369 0 73  SER A CA  1 ? 
ATOM   548  C  C   . SER A 1 73  ? 5.447   -4.937  35.739  1.000 11.580 0 73  SER A C   1 ? 
ATOM   549  O  O   . SER A 1 73  ? 4.985   -3.804  35.950  1.000 11.607 0 73  SER A O   1 ? 
ATOM   550  C  CB  . SER A 1 73  ? 4.888   -7.016  37.022  1.000 15.711 0 73  SER A CB  1 ? 
ATOM   551  O  OG  . SER A 1 73  ? 3.686   -6.508  37.533  1.000 20.191 0 73  SER A OG  1 ? 
ATOM   552  N  N   . GLY A 1 74  ? 5.529   -5.518  34.545  1.000 12.166 0 74  GLY A N   1 ? 
ATOM   553  C  CA  . GLY A 1 74  ? 4.954   -4.923  33.347  1.000 11.664 0 74  GLY A CA  1 ? 
ATOM   554  C  C   . GLY A 1 74  ? 5.465   -3.526  33.038  1.000 11.487 0 74  GLY A C   1 ? 
ATOM   555  O  O   . GLY A 1 74  ? 6.642   -3.232  33.221  1.000 11.499 0 74  GLY A O   1 ? 
ATOM   556  N  N   . ASN A 1 75  ? 4.576   -2.706  32.476  1.000 11.334 0 75  ASN A N   1 ? 
ATOM   557  C  CA  . ASN A 1 75  ? 4.987   -1.416  31.974  1.000 10.553 0 75  ASN A CA  1 ? 
ATOM   558  C  C   . ASN A 1 75  ? 5.419   -0.520  33.114  1.000 10.141 0 75  ASN A C   1 ? 
ATOM   559  O  O   . ASN A 1 75  ? 6.317   0.295   32.938  1.000 8.972  0 75  ASN A O   1 ? 
ATOM   560  C  CB  . ASN A 1 75  ? 3.859   -0.780  31.170  1.000 11.556 0 75  ASN A CB  1 ? 
ATOM   561  C  CG  . ASN A 1 75  ? 3.618   -1.456  29.845  1.000 14.422 0 75  ASN A CG  1 ? 
ATOM   562  O  OD1 . ASN A 1 75  ? 2.450   -1.627  29.440  1.000 21.152 0 75  ASN A OD1 1 ? 
ATOM   563  N  ND2 . ASN A 1 75  ? 4.658   -1.761  29.141  1.000 14.365 0 75  ASN A ND2 1 ? 
ATOM   564  N  N   . PHE A 1 76  ? 4.768   -0.614  34.265  1.000 9.458  0 76  PHE A N   1 ? 
ATOM   565  C  CA  . PHE A 1 76  ? 5.191   0.172   35.412  1.000 9.326  0 76  PHE A CA  1 ? 
ATOM   566  C  C   . PHE A 1 76  ? 6.631   -0.174  35.761  1.000 9.284  0 76  PHE A C   1 ? 
ATOM   567  O  O   . PHE A 1 76  ? 7.425   0.753   36.038  1.000 8.720  0 76  PHE A O   1 ? 
ATOM   568  C  CB  . PHE A 1 76  ? 4.314   -0.058  36.634  1.000 9.250  0 76  PHE A CB  1 ? 
ATOM   569  C  CG  . PHE A 1 76  ? 4.608   0.810   37.831  1.000 9.702  0 76  PHE A CG  1 ? 
ATOM   570  C  CD1 . PHE A 1 76  ? 4.664   2.182   37.739  1.000 9.108  0 76  PHE A CD1 1 ? 
ATOM   571  C  CD2 . PHE A 1 76  ? 4.871   0.221   39.059  1.000 9.756  0 76  PHE A CD2 1 ? 
ATOM   572  C  CE1 . PHE A 1 76  ? 4.923   2.933   38.847  1.000 9.216  0 76  PHE A CE1 1 ? 
ATOM   573  C  CE2 . PHE A 1 76  ? 5.163   0.963   40.159  1.000 9.421  0 76  PHE A CE2 1 ? 
ATOM   574  C  CZ  . PHE A 1 76  ? 5.149   2.351   40.066  1.000 8.515  0 76  PHE A CZ  1 ? 
ATOM   575  N  N   . GLU A 1 77  ? 6.985   -1.469  35.871  1.000 9.131  0 77  GLU A N   1 ? 
ATOM   576  C  CA  . GLU A 1 77  ? 8.372   -1.825  36.134  1.000 10.023 0 77  GLU A CA  1 ? 
ATOM   577  C  C   . GLU A 1 77  ? 9.300   -1.226  35.088  1.000 9.602  0 77  GLU A C   1 ? 
ATOM   578  O  O   . GLU A 1 77  ? 10.381  -0.724  35.418  1.000 8.918  0 77  GLU A O   1 ? 
ATOM   579  C  CB  . GLU A 1 77  ? 8.523   -3.349  36.193  1.000 9.917  0 77  GLU A CB  1 ? 
ATOM   580  C  CG  . GLU A 1 77  ? 9.949   -3.837  36.390  1.000 12.124 0 77  GLU A CG  1 ? 
ATOM   581  C  CD  . GLU A 1 77  ? 10.166  -5.338  36.345  1.000 16.798 0 77  GLU A CD  1 ? 
ATOM   582  O  OE1 . GLU A 1 77  ? 9.175   -6.104  36.405  1.000 23.677 0 77  GLU A OE1 1 ? 
ATOM   583  O  OE2 . GLU A 1 77  ? 11.346  -5.745  36.305  1.000 19.855 0 77  GLU A OE2 1 ? 
ATOM   584  N  N   . GLN A 1 78  ? 8.897   -1.284  33.817  1.000 9.165  0 78  GLN A N   1 ? 
ATOM   585  C  CA  . GLN A 1 78  ? 9.777   -0.828  32.757  1.000 9.072  0 78  GLN A CA  1 ? 
ATOM   586  C  C   . GLN A 1 78  ? 10.067  0.665   32.936  1.000 8.267  0 78  GLN A C   1 ? 
ATOM   587  O  O   . GLN A 1 78  ? 11.225  1.114   32.766  1.000 9.079  0 78  GLN A O   1 ? 
ATOM   588  C  CB  . GLN A 1 78  ? 9.138   -1.088  31.399  1.000 10.404 0 78  GLN A CB  1 ? 
ATOM   589  C  CG  . GLN A 1 78  ? 10.083  -0.823  30.234  1.000 10.865 0 78  GLN A CG  1 ? 
ATOM   590  C  CD  . GLN A 1 78  ? 9.439   -1.155  28.920  1.000 12.181 0 78  GLN A CD  1 ? 
ATOM   591  O  OE1 . GLN A 1 78  ? 8.613   -2.060  28.826  1.000 13.195 0 78  GLN A OE1 1 ? 
ATOM   592  N  NE2 . GLN A 1 78  ? 9.870   -0.469  27.883  1.000 12.212 0 78  GLN A NE2 1 ? 
ATOM   593  N  N   . VAL A 1 79  ? 9.060   1.469   33.258  1.000 7.809  0 79  VAL A N   1 ? 
ATOM   594  C  CA  . VAL A 1 79  ? 9.255   2.915   33.437  1.000 8.358  0 79  VAL A CA  1 ? 
ATOM   595  C  C   . VAL A 1 79  ? 10.134  3.157   34.666  1.000 8.284  0 79  VAL A C   1 ? 
ATOM   596  O  O   . VAL A 1 79  ? 11.084  3.960   34.594  1.000 7.035  0 79  VAL A O   1 ? 
ATOM   597  C  CB  . VAL A 1 79  ? 7.939   3.703   33.601  1.000 9.443  0 79  VAL A CB  1 ? 
ATOM   598  C  CG1 . VAL A 1 79  ? 8.221   5.172   33.967  1.000 9.930  0 79  VAL A CG1 1 ? 
ATOM   599  C  CG2 . VAL A 1 79  ? 7.021   3.594   32.415  1.000 10.587 0 79  VAL A CG2 1 ? 
ATOM   600  N  N   . ILE A 1 80  ? 9.846   2.517   35.804  1.000 8.212  0 80  ILE A N   1 ? 
ATOM   601  C  CA  . ILE A 1 80  ? 10.595  2.785   37.036  1.000 8.412  0 80  ILE A CA  1 ? 
ATOM   602  C  C   . ILE A 1 80  ? 12.059  2.380   36.837  1.000 8.961  0 80  ILE A C   1 ? 
ATOM   603  O  O   . ILE A 1 80  ? 12.968  3.122   37.254  1.000 7.913  0 80  ILE A O   1 ? 
ATOM   604  C  CB  . ILE A 1 80  ? 9.902   2.086   38.214  1.000 8.672  0 80  ILE A CB  1 ? 
ATOM   605  C  CG1 . ILE A 1 80  ? 8.574   2.706   38.561  1.000 9.320  0 80  ILE A CG1 1 ? 
ATOM   606  C  CG2 . ILE A 1 80  ? 10.840  2.030   39.418  1.000 9.591  0 80  ILE A CG2 1 ? 
ATOM   607  C  CD1 . ILE A 1 80  ? 8.641   4.127   39.105  1.000 9.827  0 80  ILE A CD1 1 ? 
ATOM   608  N  N   . VAL A 1 81  ? 12.320  1.167   36.329  1.000 8.112  0 81  VAL A N   1 ? 
ATOM   609  C  CA  . VAL A 1 81  ? 13.709  0.745   36.140  1.000 8.967  0 81  VAL A CA  1 ? 
ATOM   610  C  C   . VAL A 1 81  ? 14.378  1.661   35.123  1.000 8.501  0 81  VAL A C   1 ? 
ATOM   611  O  O   . VAL A 1 81  ? 15.546  2.017   35.316  1.000 9.335  0 81  VAL A O   1 ? 
ATOM   612  C  CB  . VAL A 1 81  ? 13.783  -0.738  35.721  1.000 11.785 0 81  VAL A CB  1 ? 
ATOM   613  C  CG1 . VAL A 1 81  ? 15.191  -1.183  35.325  1.000 12.730 0 81  VAL A CG1 1 ? 
ATOM   614  C  CG2 . VAL A 1 81  ? 13.293  -1.601  36.860  1.000 13.393 0 81  VAL A CG2 1 ? 
ATOM   615  N  N   . GLY A 1 82  ? 13.669  2.126   34.091  1.000 8.011  0 82  GLY A N   1 ? 
ATOM   616  C  CA  . GLY A 1 82  ? 14.247  3.080   33.158  1.000 8.497  0 82  GLY A CA  1 ? 
ATOM   617  C  C   . GLY A 1 82  ? 14.642  4.362   33.856  1.000 7.933  0 82  GLY A C   1 ? 
ATOM   618  O  O   . GLY A 1 82  ? 15.747  4.900   33.645  1.000 7.985  0 82  GLY A O   1 ? 
ATOM   619  N  N   . MET A 1 83  ? 13.786  4.871   34.748  1.000 7.863  0 83  MET A N   1 ? 
ATOM   620  C  CA  . MET A 1 83  ? 14.081  6.077   35.495  1.000 7.397  0 83  MET A CA  1 ? 
ATOM   621  C  C   . MET A 1 83  ? 15.328  5.907   36.355  1.000 7.377  0 83  MET A C   1 ? 
ATOM   622  O  O   . MET A 1 83  ? 16.062  6.871   36.621  1.000 8.040  0 83  MET A O   1 ? 
ATOM   623  C  CB  . MET A 1 83  ? 12.896  6.467   36.382  1.000 7.399  0 83  MET A CB  1 ? 
ATOM   624  C  CG  . MET A 1 83  ? 11.732  7.042   35.601  1.000 6.975  0 83  MET A CG  1 ? 
ATOM   625  S  SD  . MET A 1 83  ? 10.168  7.062   36.490  1.000 8.806  0 83  MET A SD  1 ? 
ATOM   626  C  CE  . MET A 1 83  ? 10.572  8.104   37.888  1.000 9.003  0 83  MET A CE  1 ? 
ATOM   627  N  N   . MET A 1 84  ? 15.525  4.712   36.891  1.000 7.610  0 84  MET A N   1 ? 
ATOM   628  C  CA  . MET A 1 84  ? 16.649  4.423   37.774  1.000 7.822  0 84  MET A CA  1 ? 
ATOM   629  C  C   . MET A 1 84  ? 17.974  4.220   37.023  1.000 8.061  0 84  MET A C   1 ? 
ATOM   630  O  O   . MET A 1 84  ? 19.021  4.204   37.675  1.000 10.046 0 84  MET A O   1 ? 
ATOM   631  C  CB  . MET A 1 84  ? 16.391  3.127   38.539  1.000 8.436  0 84  MET A CB  1 ? 
ATOM   632  C  CG  . MET A 1 84  ? 15.307  3.242   39.573  1.000 9.491  0 84  MET A CG  1 ? 
ATOM   633  S  SD  . MET A 1 84  ? 15.532  4.546   40.784  1.000 10.146 0 84  MET A SD  1 ? 
ATOM   634  C  CE  . MET A 1 84  ? 17.170  4.224   41.416  1.000 11.856 0 84  MET A CE  1 ? 
ATOM   635  N  N   . THR A 1 85  ? 17.936  4.111   35.696  1.000 8.350  0 85  THR A N   1 ? 
ATOM   636  C  CA  . THR A 1 85  ? 19.122  3.833   34.880  1.000 8.573  0 85  THR A CA  1 ? 
ATOM   637  C  C   . THR A 1 85  ? 19.840  5.140   34.547  1.000 9.040  0 85  THR A C   1 ? 
ATOM   638  O  O   . THR A 1 85  ? 19.241  6.096   34.090  1.000 8.862  0 85  THR A O   1 ? 
ATOM   639  C  CB  . THR A 1 85  ? 18.704  3.068   33.614  1.000 9.726  0 85  THR A CB  1 ? 
ATOM   640  O  OG1 . THR A 1 85  ? 17.971  1.911   34.002  1.000 10.038 0 85  THR A OG1 1 ? 
ATOM   641  C  CG2 . THR A 1 85  ? 19.896  2.657   32.766  1.000 9.405  0 85  THR A CG2 1 ? 
ATOM   642  N  N   . PRO A 1 86  ? 21.183  5.235   34.729  1.000 9.375  0 86  PRO A N   1 ? 
ATOM   643  C  CA  . PRO A 1 86  ? 21.888  6.420   34.280  1.000 9.961  0 86  PRO A CA  1 ? 
ATOM   644  C  C   . PRO A 1 86  ? 21.590  6.768   32.821  1.000 8.888  0 86  PRO A C   1 ? 
ATOM   645  O  O   . PRO A 1 86  ? 21.401  5.877   31.995  1.000 9.118  0 86  PRO A O   1 ? 
ATOM   646  C  CB  . PRO A 1 86  ? 23.380  6.006   34.432  1.000 11.083 0 86  PRO A CB  1 ? 
ATOM   647  C  CG  . PRO A 1 86  ? 23.348  5.034   35.587  1.000 11.158 0 86  PRO A CG  1 ? 
ATOM   648  C  CD  . PRO A 1 86  ? 22.050  4.250   35.390  1.000 10.792 0 86  PRO A CD  1 ? 
ATOM   649  N  N   . THR A 1 87  ? 21.532  8.049   32.499  1.000 10.158 0 87  THR A N   1 ? 
ATOM   650  C  CA  . THR A 1 87  ? 21.106  8.534   31.217  1.000 10.238 0 87  THR A CA  1 ? 
ATOM   651  C  C   . THR A 1 87  ? 21.832  7.831   30.053  1.000 9.711  0 87  THR A C   1 ? 
ATOM   652  O  O   . THR A 1 87  ? 21.164  7.358   29.086  1.000 9.320  0 87  THR A O   1 ? 
ATOM   653  C  CB  . THR A 1 87  ? 21.353  10.048  31.155  1.000 13.571 0 87  THR A CB  1 ? 
ATOM   654  O  OG1 . THR A 1 87  ? 20.718  10.666  32.281  1.000 15.649 0 87  THR A OG1 1 ? 
ATOM   655  C  CG2 . THR A 1 87  ? 20.877  10.678  29.868  1.000 16.163 0 87  THR A CG2 1 ? 
ATOM   656  N  N   . VAL A 1 88  ? 23.181  7.810   30.069  1.000 9.393  0 88  VAL A N   1 ? 
ATOM   657  C  CA  . VAL A 1 88  ? 23.914  7.240   28.946  1.000 8.965  0 88  VAL A CA  1 ? 
ATOM   658  C  C   . VAL A 1 88  ? 23.561  5.752   28.812  1.000 8.349  0 88  VAL A C   1 ? 
ATOM   659  O  O   . VAL A 1 88  ? 23.325  5.235   27.721  1.000 8.385  0 88  VAL A O   1 ? 
ATOM   660  C  CB  . VAL A 1 88  ? 25.434  7.455   29.092  1.000 10.016 0 88  VAL A CB  1 ? 
ATOM   661  C  CG1 . VAL A 1 88  ? 26.162  6.751   27.955  1.000 9.951  0 88  VAL A CG1 1 ? 
ATOM   662  C  CG2 . VAL A 1 88  ? 25.766  8.929   29.115  1.000 12.504 0 88  VAL A CG2 1 ? 
ATOM   663  N  N   . LEU A 1 89  ? 23.594  5.046   29.912  1.000 8.276  0 89  LEU A N   1 ? 
ATOM   664  C  CA  . LEU A 1 89  ? 23.357  3.607   29.922  1.000 8.074  0 89  LEU A CA  1 ? 
ATOM   665  C  C   . LEU A 1 89  ? 21.941  3.275   29.435  1.000 8.520  0 89  LEU A C   1 ? 
ATOM   666  O  O   . LEU A 1 89  ? 21.734  2.246   28.805  1.000 8.381  0 89  LEU A O   1 ? 
ATOM   667  C  CB  . LEU A 1 89  ? 23.607  2.997   31.319  1.000 9.516  0 89  LEU A CB  1 ? 
ATOM   668  C  CG  . LEU A 1 89  ? 23.553  1.483   31.399  1.000 10.220 0 89  LEU A CG  1 ? 
ATOM   669  C  CD1 . LEU A 1 89  ? 24.612  0.832   30.505  1.000 12.978 0 89  LEU A CD1 1 ? 
ATOM   670  C  CD2 . LEU A 1 89  ? 23.701  1.025   32.810  1.000 11.361 0 89  LEU A CD2 1 ? 
ATOM   671  N  N   . TYR A 1 90  ? 20.950  4.141   29.733  1.000 8.181  0 90  TYR A N   1 ? 
ATOM   672  C  CA  . TYR A 1 90  ? 19.594  3.871   29.265  1.000 7.824  0 90  TYR A CA  1 ? 
ATOM   673  C  C   . TYR A 1 90  ? 19.560  3.875   27.739  1.000 7.087  0 90  TYR A C   1 ? 
ATOM   674  O  O   . TYR A 1 90  ? 18.973  2.985   27.122  1.000 7.911  0 90  TYR A O   1 ? 
ATOM   675  C  CB  . TYR A 1 90  ? 18.634  4.889   29.893  1.000 7.817  0 90  TYR A CB  1 ? 
ATOM   676  C  CG  . TYR A 1 90  ? 17.187  4.647   29.499  1.000 7.915  0 90  TYR A CG  1 ? 
ATOM   677  C  CD1 . TYR A 1 90  ? 16.539  3.504   29.861  1.000 8.871  0 90  TYR A CD1 1 ? 
ATOM   678  C  CD2 . TYR A 1 90  ? 16.466  5.572   28.739  1.000 8.026  0 90  TYR A CD2 1 ? 
ATOM   679  C  CE1 . TYR A 1 90  ? 15.220  3.242   29.523  1.000 9.043  0 90  TYR A CE1 1 ? 
ATOM   680  C  CE2 . TYR A 1 90  ? 15.128  5.356   28.428  1.000 9.120  0 90  TYR A CE2 1 ? 
ATOM   681  C  CZ  . TYR A 1 90  ? 14.518  4.189   28.821  1.000 9.343  0 90  TYR A CZ  1 ? 
ATOM   682  O  OH  . TYR A 1 90  ? 13.196  3.985   28.459  1.000 10.612 0 90  TYR A OH  1 ? 
ATOM   683  N  N   . ASP A 1 91  ? 20.204  4.876   27.122  1.000 7.464  0 91  ASP A N   1 ? 
ATOM   684  C  CA  . ASP A 1 91  ? 20.279  4.903   25.679  1.000 7.843  0 91  ASP A CA  1 ? 
ATOM   685  C  C   . ASP A 1 91  ? 21.038  3.707   25.115  1.000 7.605  0 91  ASP A C   1 ? 
ATOM   686  O  O   . ASP A 1 91  ? 20.641  3.131   24.114  1.000 7.158  0 91  ASP A O   1 ? 
ATOM   687  C  CB  . ASP A 1 91  ? 20.902  6.202   25.213  1.000 8.646  0 91  ASP A CB  1 ? 
ATOM   688  C  CG  . ASP A 1 91  ? 20.051  7.459   25.309  1.000 10.555 0 91  ASP A CG  1 ? 
ATOM   689  O  OD1 . ASP A 1 91  ? 18.876  7.338   25.672  1.000 9.314  0 91  ASP A OD1 1 ? 
ATOM   690  O  OD2 . ASP A 1 91  ? 20.584  8.560   24.987  1.000 12.168 0 91  ASP A OD2 1 ? 
ATOM   691  N  N   . VAL A 1 92  ? 22.136  3.336   25.748  1.000 6.606  0 92  VAL A N   1 ? 
ATOM   692  C  CA  . VAL A 1 92  ? 22.909  2.172   25.334  1.000 7.498  0 92  VAL A CA  1 ? 
ATOM   693  C  C   . VAL A 1 92  ? 22.043  0.922   25.339  1.000 8.399  0 92  VAL A C   1 ? 
ATOM   694  O  O   . VAL A 1 92  ? 22.059  0.103   24.412  1.000 8.313  0 92  VAL A O   1 ? 
ATOM   695  C  CB  . VAL A 1 92  ? 24.127  2.023   26.247  1.000 8.351  0 92  VAL A CB  1 ? 
ATOM   696  C  CG1 . VAL A 1 92  ? 24.800  0.669   26.157  1.000 8.277  0 92  VAL A CG1 1 ? 
ATOM   697  C  CG2 . VAL A 1 92  ? 25.143  3.132   26.009  1.000 8.421  0 92  VAL A CG2 1 ? 
ATOM   698  N  N   . GLN A 1 93  ? 21.322  0.730   26.436  1.000 7.551  0 93  GLN A N   1 ? 
ATOM   699  C  CA  . GLN A 1 93  ? 20.504  -0.460  26.608  1.000 8.338  0 93  GLN A CA  1 ? 
ATOM   700  C  C   . GLN A 1 93  ? 19.357  -0.450  25.593  1.000 7.946  0 93  GLN A C   1 ? 
ATOM   701  O  O   . GLN A 1 93  ? 18.986  -1.511  25.084  1.000 8.481  0 93  GLN A O   1 ? 
ATOM   702  C  CB  . GLN A 1 93  ? 20.030  -0.566  28.050  1.000 9.288  0 93  GLN A CB  1 ? 
ATOM   703  C  CG  . GLN A 1 93  ? 21.167  -0.886  29.003  1.000 11.632 0 93  GLN A CG  1 ? 
ATOM   704  C  CD  . GLN A 1 93  ? 20.822  -1.037  30.462  1.000 15.782 0 93  GLN A CD  1 ? 
ATOM   705  O  OE1 . GLN A 1 93  ? 19.752  -0.620  30.878  1.000 15.936 0 93  GLN A OE1 1 ? 
ATOM   706  N  NE2 . GLN A 1 93  ? 21.734  -1.600  31.239  1.000 20.090 0 93  GLN A NE2 1 ? 
ATOM   707  N  N   . GLU A 1 94  ? 18.761  0.706   25.279  1.000 7.552  0 94  GLU A N   1 ? 
ATOM   708  C  CA  . GLU A 1 94  ? 17.707  0.773   24.274  1.000 8.219  0 94  GLU A CA  1 ? 
ATOM   709  C  C   . GLU A 1 94  ? 18.254  0.422   22.894  1.000 7.929  0 94  GLU A C   1 ? 
ATOM   710  O  O   . GLU A 1 94  ? 17.586  -0.297  22.138  1.000 8.249  0 94  GLU A O   1 ? 
ATOM   711  C  CB  . GLU A 1 94  ? 17.047  2.153   24.322  1.000 8.107  0 94  GLU A CB  1 ? 
ATOM   712  C  CG  . GLU A 1 94  ? 16.067  2.249   25.491  1.000 9.858  0 94  GLU A CG  1 ? 
ATOM   713  C  CD  . GLU A 1 94  ? 14.863  1.401   25.298  1.000 12.085 0 94  GLU A CD  1 ? 
ATOM   714  O  OE1 . GLU A 1 94  ? 14.085  1.625   24.351  1.000 11.086 0 94  GLU A OE1 1 ? 
ATOM   715  O  OE2 . GLU A 1 94  ? 14.736  0.419   26.101  1.000 16.764 0 94  GLU A OE2 1 ? 
ATOM   716  N  N   . LEU A 1 95  ? 19.472  0.890   22.542  1.000 7.858  0 95  LEU A N   1 ? 
ATOM   717  C  CA  . LEU A 1 95  ? 20.055  0.536   21.247  1.000 7.917  0 95  LEU A CA  1 ? 
ATOM   718  C  C   . LEU A 1 95  ? 20.339  -0.961  21.165  1.000 7.756  0 95  LEU A C   1 ? 
ATOM   719  O  O   . LEU A 1 95  ? 20.131  -1.598  20.127  1.000 8.584  0 95  LEU A O   1 ? 
ATOM   720  C  CB  . LEU A 1 95  ? 21.334  1.316   21.016  1.000 8.421  0 95  LEU A CB  1 ? 
ATOM   721  C  CG  . LEU A 1 95  ? 21.116  2.826   20.776  1.000 8.476  0 95  LEU A CG  1 ? 
ATOM   722  C  CD1 . LEU A 1 95  ? 22.479  3.523   20.830  1.000 9.945  0 95  LEU A CD1 1 ? 
ATOM   723  C  CD2 . LEU A 1 95  ? 20.400  3.140   19.450  1.000 9.302  0 95  LEU A CD2 1 ? 
ATOM   724  N  N   . ARG A 1 96  ? 20.868  -1.523  22.255  1.000 8.188  0 96  ARG A N   1 ? 
ATOM   725  C  CA  . ARG A 1 96  ? 21.148  -2.954  22.303  1.000 8.798  0 96  ARG A CA  1 ? 
ATOM   726  C  C   . ARG A 1 96  ? 19.839  -3.737  22.136  1.000 8.865  0 96  ARG A C   1 ? 
ATOM   727  O  O   . ARG A 1 96  ? 19.793  -4.694  21.347  1.000 9.728  0 96  ARG A O   1 ? 
ATOM   728  C  CB  . ARG A 1 96  ? 21.919  -3.357  23.570  1.000 10.309 0 96  ARG A CB  1 ? 
ATOM   729  C  CG  . ARG A 1 96  ? 22.171  -4.864  23.703  1.000 11.251 0 96  ARG A CG  1 ? 
ATOM   730  C  CD  . ARG A 1 96  ? 23.211  -5.338  22.772  1.000 13.619 0 96  ARG A CD  1 ? 
ATOM   731  N  NE  . ARG A 1 96  ? 23.424  -6.745  23.139  1.000 17.173 0 96  ARG A NE  1 ? 
ATOM   732  C  CZ  . ARG A 1 96  ? 23.155  -7.806  22.388  1.000 15.830 0 96  ARG A CZ  1 ? 
ATOM   733  N  NH1 . ARG A 1 96  ? 22.961  -7.653  21.113  1.000 14.694 0 96  ARG A NH1 1 ? 
ATOM   734  N  NH2 . ARG A 1 96  ? 23.215  -9.021  22.915  1.000 18.689 0 96  ARG A NH2 1 ? 
ATOM   735  N  N   . ARG A 1 97  ? 18.791  -3.384  22.862  1.000 9.676  0 97  ARG A N   1 ? 
ATOM   736  C  CA  . ARG A 1 97  ? 17.524  -4.064  22.739  1.000 9.497  0 97  ARG A CA  1 ? 
ATOM   737  C  C   . ARG A 1 97  ? 17.020  -3.960  21.315  1.000 9.145  0 97  ARG A C   1 ? 
ATOM   738  O  O   . ARG A 1 97  ? 16.411  -4.910  20.803  1.000 9.645  0 97  ARG A O   1 ? 
ATOM   739  C  CB  . ARG A 1 97  ? 16.558  -3.421  23.717  1.000 12.627 0 97  ARG A CB  1 ? 
ATOM   740  C  CG  . ARG A 1 97  ? 15.179  -4.015  23.783  1.000 16.121 0 97  ARG A CG  1 ? 
ATOM   741  C  CD  . ARG A 1 97  ? 14.702  -3.369  25.084  1.000 24.213 0 97  ARG A CD  1 ? 
ATOM   742  N  NE  . ARG A 1 97  ? 13.296  -3.702  25.152  1.000 27.311 0 97  ARG A NE  1 ? 
ATOM   743  C  CZ  . ARG A 1 97  ? 12.302  -2.892  25.363  1.000 29.740 0 97  ARG A CZ  1 ? 
ATOM   744  N  NH1 . ARG A 1 97  ? 12.507  -1.604  25.606  1.000 25.225 0 97  ARG A NH1 1 ? 
ATOM   745  N  NH2 . ARG A 1 97  ? 11.111  -3.465  25.411  1.000 29.358 0 97  ARG A NH2 1 ? 
ATOM   746  N  N   . ALA A 1 98  ? 17.180  -2.811  20.653  1.000 8.052  0 98  ALA A N   1 ? 
ATOM   747  C  CA  . ALA A 1 98  ? 16.711  -2.607  19.312  1.000 9.203  0 98  ALA A CA  1 ? 
ATOM   748  C  C   . ALA A 1 98  ? 17.358  -3.575  18.341  1.000 8.577  0 98  ALA A C   1 ? 
ATOM   749  O  O   . ALA A 1 98  ? 16.733  -3.943  17.342  1.000 10.400 0 98  ALA A O   1 ? 
ATOM   750  C  CB  . ALA A 1 98  ? 16.970  -1.162  18.880  1.000 8.647  0 98  ALA A CB  1 ? 
ATOM   751  N  N   . MET A 1 99  ? 18.608  -3.976  18.563  1.000 8.648  0 99  MET A N   1 ? 
ATOM   752  C  CA  . MET A 1 99  ? 19.338  -4.798  17.611  1.000 9.321  0 99  MET A CA  1 ? 
ATOM   753  C  C   . MET A 1 99  ? 19.473  -6.258  18.059  1.000 9.537  0 99  MET A C   1 ? 
ATOM   754  O  O   . MET A 1 99  ? 19.924  -7.115  17.270  1.000 10.636 0 99  MET A O   1 ? 
ATOM   755  C  CB  . MET A 1 99  ? 20.704  -4.178  17.293  1.000 9.441  0 99  MET A CB  1 ? 
ATOM   756  C  CG  . MET A 1 99  ? 20.539  -2.871  16.482  1.000 9.620  0 99  MET A CG  1 ? 
ATOM   757  S  SD  . MET A 1 99  ? 22.119  -2.149  15.995  1.000 10.745 0 99  MET A SD  1 ? 
ATOM   758  C  CE  . MET A 1 99  ? 22.545  -1.398  17.576  1.000 11.794 0 99  MET A CE  1 ? 
ATOM   759  N  N   . LYS A 1 100 ? 19.203  -6.588  19.313  1.000 10.038 0 100 LYS A N   1 ? 
ATOM   760  C  CA  . LYS A 1 100 ? 19.455  -7.940  19.843  1.000 10.859 0 100 LYS A CA  1 ? 
ATOM   761  C  C   . LYS A 1 100 ? 18.576  -8.991  19.142  1.000 11.680 0 100 LYS A C   1 ? 
ATOM   762  O  O   . LYS A 1 100 ? 17.383  -8.775  18.960  1.000 12.751 0 100 LYS A O   1 ? 
ATOM   763  C  CB  . LYS A 1 100 ? 19.190  -7.983  21.353  1.000 12.740 0 100 LYS A CB  1 ? 
ATOM   764  C  CG  . LYS A 1 100 ? 19.461  -9.375  21.948  1.000 15.314 0 100 LYS A CG  1 ? 
ATOM   765  C  CD  . LYS A 1 100 ? 19.435  -9.352  23.478  1.000 19.454 0 100 LYS A CD  1 ? 
ATOM   766  C  CE  . LYS A 1 100 ? 19.683  -10.723 24.074  1.000 22.814 0 100 LYS A CE  1 ? 
ATOM   767  N  NZ  . LYS A 1 100 ? 19.691  -10.571 25.531  1.000 26.852 0 100 LYS A NZ  1 ? 
ATOM   768  N  N   . GLY A 1 101 ? 19.197  -10.132 18.809  1.000 11.546 0 101 GLY A N   1 ? 
ATOM   769  C  CA  . GLY A 1 101 ? 18.466  -11.249 18.244  1.000 13.186 0 101 GLY A CA  1 ? 
ATOM   770  C  C   . GLY A 1 101 ? 17.944  -10.939 16.848  1.000 12.521 0 101 GLY A C   1 ? 
ATOM   771  O  O   . GLY A 1 101 ? 18.599  -10.238 16.068  1.000 14.230 0 101 GLY A O   1 ? 
ATOM   772  N  N   . ALA A 1 102 ? 16.813  -11.554 16.490  1.000 12.930 0 102 ALA A N   1 ? 
ATOM   773  C  CA  . ALA A 1 102 ? 16.345  -11.569 15.093  1.000 14.227 0 102 ALA A CA  1 ? 
ATOM   774  C  C   . ALA A 1 102 ? 15.801  -10.225 14.594  1.000 18.196 0 102 ALA A C   1 ? 
ATOM   775  O  O   . ALA A 1 102 ? 16.190  -9.769  13.509  1.000 21.987 0 102 ALA A O   1 ? 
ATOM   776  C  CB  . ALA A 1 102 ? 15.289  -12.653 14.908  1.000 13.859 0 102 ALA A CB  1 ? 
ATOM   777  N  N   . GLY A 1 103 ? 14.958  -9.561  15.367  1.000 18.034 0 103 GLY A N   1 ? 
ATOM   778  C  CA  . GLY A 1 103 ? 14.324  -8.349  14.845  1.000 16.609 0 103 GLY A CA  1 ? 
ATOM   779  C  C   . GLY A 1 103 ? 15.250  -7.131  14.933  1.000 13.724 0 103 GLY A C   1 ? 
ATOM   780  O  O   . GLY A 1 103 ? 16.182  -7.141  15.722  1.000 13.671 0 103 GLY A O   1 ? 
ATOM   781  N  N   . THR A 1 104 ? 14.916  -6.054  14.192  1.000 13.054 0 104 THR A N   1 ? 
ATOM   782  C  CA  . THR A 1 104 ? 15.626  -4.785  14.371  1.000 11.879 0 104 THR A CA  1 ? 
ATOM   783  C  C   . THR A 1 104 ? 14.579  -3.684  14.523  1.000 11.562 0 104 THR A C   1 ? 
ATOM   784  O  O   . THR A 1 104 ? 13.791  -3.448  13.613  1.000 12.467 0 104 THR A O   1 ? 
ATOM   785  C  CB  . THR A 1 104 ? 16.568  -4.513  13.193  1.000 12.343 0 104 THR A CB  1 ? 
ATOM   786  O  OG1 . THR A 1 104 ? 17.505  -5.595  13.060  1.000 14.002 0 104 THR A OG1 1 ? 
ATOM   787  C  CG2 . THR A 1 104 ? 17.341  -3.232  13.432  1.000 12.088 0 104 THR A CG2 1 ? 
ATOM   788  N  N   . ASP A 1 105 ? 14.643  -2.926  15.631  1.000 10.341 0 105 ASP A N   1 ? 
ATOM   789  C  CA  . ASP A 1 105 ? 13.741  -1.810  15.878  1.000 10.504 0 105 ASP A CA  1 ? 
ATOM   790  C  C   . ASP A 1 105 ? 14.365  -0.562  15.263  1.000 9.342  0 105 ASP A C   1 ? 
ATOM   791  O  O   . ASP A 1 105 ? 15.062  0.206   15.915  1.000 9.379  0 105 ASP A O   1 ? 
ATOM   792  C  CB  . ASP A 1 105 ? 13.493  -1.661  17.363  1.000 10.530 0 105 ASP A CB  1 ? 
ATOM   793  C  CG  . ASP A 1 105 ? 12.521  -0.566  17.781  1.000 12.351 0 105 ASP A CG  1 ? 
ATOM   794  O  OD1 . ASP A 1 105 ? 12.167  0.226   16.902  1.000 12.866 0 105 ASP A OD1 1 ? 
ATOM   795  O  OD2 . ASP A 1 105 ? 12.174  -0.498  18.963  1.000 12.221 0 105 ASP A OD2 1 ? 
ATOM   796  N  N   . GLU A 1 106 ? 14.088  -0.373  13.978  1.000 10.162 0 106 GLU A N   1 ? 
ATOM   797  C  CA  . GLU A 1 106 ? 14.658  0.719   13.203  1.000 10.657 0 106 GLU A CA  1 ? 
ATOM   798  C  C   . GLU A 1 106 ? 14.172  2.054   13.742  1.000 11.212 0 106 GLU A C   1 ? 
ATOM   799  O  O   . GLU A 1 106 ? 14.937  3.024   13.738  1.000 10.498 0 106 GLU A O   1 ? 
ATOM   800  C  CB  . GLU A 1 106 ? 14.323  0.535   11.721  1.000 13.039 0 106 GLU A CB  1 ? 
ATOM   801  C  CG  . GLU A 1 106 ? 14.967  -0.712  11.124  1.000 14.901 0 106 GLU A CG  1 ? 
ATOM   802  C  CD  . GLU A 1 106 ? 14.742  -0.935  9.651   1.000 21.416 0 106 GLU A CD  1 ? 
ATOM   803  O  OE1 . GLU A 1 106 ? 13.714  -0.407  9.226   1.000 23.043 0 106 GLU A OE1 1 ? 
ATOM   804  O  OE2 . GLU A 1 106 ? 15.612  -1.528  8.987   1.000 26.296 0 106 GLU A OE2 1 ? 
ATOM   805  N  N   . GLY A 1 107 ? 12.925  2.110   14.235  1.000 10.775 0 107 GLY A N   1 ? 
ATOM   806  C  CA  . GLY A 1 107 ? 12.395  3.330   14.786  1.000 10.554 0 107 GLY A CA  1 ? 
ATOM   807  C  C   . GLY A 1 107 ? 13.197  3.845   15.966  1.000 9.844  0 107 GLY A C   1 ? 
ATOM   808  O  O   . GLY A 1 107 ? 13.467  5.040   16.104  1.000 10.564 0 107 GLY A O   1 ? 
ATOM   809  N  N   . CYS A 1 108 ? 13.599  2.954   16.865  1.000 9.552  0 108 CYS A N   1 ? 
ATOM   810  C  CA  . CYS A 1 108 ? 14.405  3.325   18.008  1.000 9.555  0 108 CYS A CA  1 ? 
ATOM   811  C  C   . CYS A 1 108 ? 15.793  3.801   17.561  1.000 8.335  0 108 CYS A C   1 ? 
ATOM   812  O  O   . CYS A 1 108 ? 16.319  4.801   18.058  1.000 8.405  0 108 CYS A O   1 ? 
ATOM   813  C  CB  . CYS A 1 108 ? 14.523  2.131   18.953  1.000 9.893  0 108 CYS A CB  1 ? 
ATOM   814  S  SG  . CYS A 1 108 ? 15.645  2.411   20.337  1.000 10.851 0 108 CYS A SG  1 ? 
ATOM   815  N  N   . LEU A 1 109 ? 16.433  3.097   16.625  1.000 8.457  0 109 LEU A N   1 ? 
ATOM   816  C  CA  . LEU A 1 109 ? 17.744  3.499   16.131  1.000 7.848  0 109 LEU A CA  1 ? 
ATOM   817  C  C   . LEU A 1 109 ? 17.652  4.920   15.586  1.000 7.292  0 109 LEU A C   1 ? 
ATOM   818  O  O   . LEU A 1 109 ? 18.532  5.726   15.883  1.000 8.301  0 109 LEU A O   1 ? 
ATOM   819  C  CB  . LEU A 1 109 ? 18.234  2.545   15.036  1.000 7.784  0 109 LEU A CB  1 ? 
ATOM   820  C  CG  . LEU A 1 109 ? 18.429  1.088   15.439  1.000 8.954  0 109 LEU A CG  1 ? 
ATOM   821  C  CD1 . LEU A 1 109 ? 18.915  0.279   14.252  1.000 9.383  0 109 LEU A CD1 1 ? 
ATOM   822  C  CD2 . LEU A 1 109 ? 19.368  0.970   16.571  1.000 10.285 0 109 LEU A CD2 1 ? 
ATOM   823  N  N   . ILE A 1 110 ? 16.657  5.230   14.783  1.000 8.084  0 110 ILE A N   1 ? 
ATOM   824  C  CA  . ILE A 1 110 ? 16.509  6.555   14.201  1.000 7.967  0 110 ILE A CA  1 ? 
ATOM   825  C  C   . ILE A 1 110 ? 16.318  7.598   15.293  1.000 8.171  0 110 ILE A C   1 ? 
ATOM   826  O  O   . ILE A 1 110 ? 16.955  8.671   15.285  1.000 8.795  0 110 ILE A O   1 ? 
ATOM   827  C  CB  . ILE A 1 110 ? 15.298  6.569   13.236  1.000 8.221  0 110 ILE A CB  1 ? 
ATOM   828  C  CG1 . ILE A 1 110 ? 15.608  5.784   11.989  1.000 8.701  0 110 ILE A CG1 1 ? 
ATOM   829  C  CG2 . ILE A 1 110 ? 14.892  7.991   12.871  1.000 8.318  0 110 ILE A CG2 1 ? 
ATOM   830  C  CD1 . ILE A 1 110 ? 14.405  5.510   11.112  1.000 9.167  0 110 ILE A CD1 1 ? 
ATOM   831  N  N   . GLU A 1 111 ? 15.396  7.291   16.228  1.000 8.607  0 111 GLU A N   1 ? 
ATOM   832  C  CA  . GLU A 1 111 ? 15.050  8.269   17.264  1.000 8.458  0 111 GLU A CA  1 ? 
ATOM   833  C  C   . GLU A 1 111 ? 16.276  8.699   18.051  1.000 8.591  0 111 GLU A C   1 ? 
ATOM   834  O  O   . GLU A 1 111 ? 16.530  9.893   18.241  1.000 9.360  0 111 GLU A O   1 ? 
ATOM   835  C  CB  . GLU A 1 111 ? 14.021  7.665   18.209  1.000 9.397  0 111 GLU A CB  1 ? 
ATOM   836  C  CG  . GLU A 1 111 ? 13.531  8.587   19.330  1.000 11.042 0 111 GLU A CG  1 ? 
ATOM   837  C  CD  . GLU A 1 111 ? 12.656  7.760   20.255  1.000 12.040 0 111 GLU A CD  1 ? 
ATOM   838  O  OE1 . GLU A 1 111 ? 11.750  7.037   19.781  1.000 12.853 0 111 GLU A OE1 1 ? 
ATOM   839  O  OE2 . GLU A 1 111 ? 12.955  7.767   21.475  1.000 12.333 0 111 GLU A OE2 1 ? 
ATOM   840  N  N   . ILE A 1 112 ? 17.052  7.738   18.555  1.000 7.730  0 112 ILE A N   1 ? 
ATOM   841  C  CA  . ILE A 1 112 ? 18.209  8.049   19.384  1.000 8.563  0 112 ILE A CA  1 ? 
ATOM   842  C  C   . ILE A 1 112 ? 19.290  8.729   18.542  1.000 8.138  0 112 ILE A C   1 ? 
ATOM   843  O  O   . ILE A 1 112 ? 19.846  9.739   18.921  1.000 8.191  0 112 ILE A O   1 ? 
ATOM   844  C  CB  . ILE A 1 112 ? 18.718  6.796   20.109  1.000 8.660  0 112 ILE A CB  1 ? 
ATOM   845  C  CG1 . ILE A 1 112 ? 17.626  6.308   21.088  1.000 9.470  0 112 ILE A CG1 1 ? 
ATOM   846  C  CG2 . ILE A 1 112 ? 20.044  7.078   20.825  1.000 9.207  0 112 ILE A CG2 1 ? 
ATOM   847  C  CD1 . ILE A 1 112 ? 18.007  5.045   21.844  1.000 10.537 0 112 ILE A CD1 1 ? 
ATOM   848  N  N   . LEU A 1 113 ? 19.641  8.160   17.385  1.000 7.773  0 113 LEU A N   1 ? 
ATOM   849  C  CA  . LEU A 1 113 ? 20.766  8.650   16.619  1.000 7.160  0 113 LEU A CA  1 ? 
ATOM   850  C  C   . LEU A 1 113 ? 20.484  10.000  15.967  1.000 7.540  0 113 LEU A C   1 ? 
ATOM   851  O  O   . LEU A 1 113 ? 21.421  10.796  15.799  1.000 8.200  0 113 LEU A O   1 ? 
ATOM   852  C  CB  . LEU A 1 113 ? 21.231  7.590   15.632  1.000 7.935  0 113 LEU A CB  1 ? 
ATOM   853  C  CG  . LEU A 1 113 ? 21.876  6.359   16.271  1.000 8.766  0 113 LEU A CG  1 ? 
ATOM   854  C  CD1 . LEU A 1 113 ? 22.111  5.260   15.278  1.000 10.192 0 113 LEU A CD1 1 ? 
ATOM   855  C  CD2 . LEU A 1 113 ? 23.160  6.731   16.967  1.000 12.499 0 113 LEU A CD2 1 ? 
ATOM   856  N  N   . ALA A 1 114 ? 19.247  10.308  15.601  1.000 7.435  0 114 ALA A N   1 ? 
ATOM   857  C  CA  . ALA A 1 114 ? 18.913  11.607  15.038  1.000 7.895  0 114 ALA A CA  1 ? 
ATOM   858  C  C   . ALA A 1 114 ? 18.805  12.693  16.100  1.000 8.180  0 114 ALA A C   1 ? 
ATOM   859  O  O   . ALA A 1 114 ? 19.066  13.852  15.776  1.000 9.655  0 114 ALA A O   1 ? 
ATOM   860  C  CB  . ALA A 1 114 ? 17.629  11.522  14.234  1.000 8.656  0 114 ALA A CB  1 ? 
ATOM   861  N  N   . SER A 1 115 ? 18.371  12.362  17.307  1.000 7.682  0 115 SER A N   1 ? 
ATOM   862  C  CA  . SER A 1 115 ? 17.985  13.375  18.286  1.000 7.551  0 115 SER A CA  1 ? 
ATOM   863  C  C   . SER A 1 115 ? 19.108  13.666  19.278  1.000 8.043  0 115 SER A C   1 ? 
ATOM   864  O  O   . SER A 1 115 ? 19.135  14.716  19.926  1.000 9.690  0 115 SER A O   1 ? 
ATOM   865  C  CB  . SER A 1 115 ? 16.712  13.008  19.032  1.000 7.824  0 115 SER A CB  1 ? 
ATOM   866  O  OG  . SER A 1 115 ? 16.941  11.897  19.908  1.000 8.039  0 115 SER A OG  1 ? 
ATOM   867  N  N   . ARG A 1 116 ? 20.038  12.735  19.484  1.000 7.844  0 116 ARG A N   1 ? 
ATOM   868  C  CA  . ARG A 1 116 ? 21.115  12.976  20.433  1.000 8.264  0 116 ARG A CA  1 ? 
ATOM   869  C  C   . ARG A 1 116 ? 22.215  13.818  19.789  1.000 8.697  0 116 ARG A C   1 ? 
ATOM   870  O  O   . ARG A 1 116 ? 22.380  13.805  18.571  1.000 9.159  0 116 ARG A O   1 ? 
ATOM   871  C  CB  . ARG A 1 116 ? 21.745  11.681  20.942  1.000 8.836  0 116 ARG A CB  1 ? 
ATOM   872  C  CG  . ARG A 1 116 ? 20.969  10.946  22.022  1.000 10.577 0 116 ARG A CG  1 ? 
ATOM   873  C  CD  . ARG A 1 116 ? 19.507  10.924  22.049  1.000 11.288 0 116 ARG A CD  1 ? 
ATOM   874  N  NE  . ARG A 1 116 ? 18.964  10.173  23.197  1.000 11.202 0 116 ARG A NE  1 ? 
ATOM   875  C  CZ  . ARG A 1 116 ? 17.698  9.953   23.253  1.000 10.821 0 116 ARG A CZ  1 ? 
ATOM   876  N  NH1 . ARG A 1 116 ? 16.844  10.573  22.445  1.000 11.163 0 116 ARG A NH1 1 ? 
ATOM   877  N  NH2 . ARG A 1 116 ? 17.258  9.108   24.163  1.000 9.479  0 116 ARG A NH2 1 ? 
ATOM   878  N  N   . THR A 1 117 ? 22.959  14.588  20.600  1.000 9.300  0 117 THR A N   1 ? 
ATOM   879  C  CA  . THR A 1 117 ? 24.080  15.337  20.078  1.000 8.673  0 117 THR A CA  1 ? 
ATOM   880  C  C   . THR A 1 117 ? 25.265  14.417  19.793  1.000 8.744  0 117 THR A C   1 ? 
ATOM   881  O  O   . THR A 1 117 ? 25.383  13.333  20.387  1.000 8.065  0 117 THR A O   1 ? 
ATOM   882  C  CB  . THR A 1 117 ? 24.546  16.392  21.082  1.000 9.849  0 117 THR A CB  1 ? 
ATOM   883  O  OG1 . THR A 1 117 ? 25.058  15.738  22.239  1.000 10.228 0 117 THR A OG1 1 ? 
ATOM   884  C  CG2 . THR A 1 117 ? 23.423  17.337  21.497  1.000 9.990  0 117 THR A CG2 1 ? 
ATOM   885  N  N   . PRO A 1 118 ? 26.218  14.845  18.947  1.000 8.890  0 118 PRO A N   1 ? 
ATOM   886  C  CA  . PRO A 1 118 ? 27.466  14.081  18.784  1.000 8.667  0 118 PRO A CA  1 ? 
ATOM   887  C  C   . PRO A 1 118 ? 28.139  13.741  20.100  1.000 8.823  0 118 PRO A C   1 ? 
ATOM   888  O  O   . PRO A 1 118 ? 28.624  12.624  20.310  1.000 8.451  0 118 PRO A O   1 ? 
ATOM   889  C  CB  . PRO A 1 118 ? 28.286  14.983  17.852  1.000 9.397  0 118 PRO A CB  1 ? 
ATOM   890  C  CG  . PRO A 1 118 ? 27.231  15.604  17.002  1.000 9.201  0 118 PRO A CG  1 ? 
ATOM   891  C  CD  . PRO A 1 118 ? 26.104  15.920  17.947  1.000 9.233  0 118 PRO A CD  1 ? 
ATOM   892  N  N   . GLU A 1 119 ? 28.203  14.685  21.036  1.000 8.430  0 119 GLU A N   1 ? 
ATOM   893  C  CA  . GLU A 1 119 ? 28.853  14.384  22.297  1.000 10.582 0 119 GLU A CA  1 ? 
ATOM   894  C  C   . GLU A 1 119 ? 28.126  13.283  23.045  1.000 9.097  0 119 GLU A C   1 ? 
ATOM   895  O  O   . GLU A 1 119 ? 28.767  12.432  23.656  1.000 9.560  0 119 GLU A O   1 ? 
ATOM   896  C  CB  . GLU A 1 119 ? 28.971  15.686  23.080  1.000 11.545 0 119 GLU A CB  1 ? 
ATOM   897  C  CG  . GLU A 1 119 ? 29.799  15.535  24.358  1.000 14.778 0 119 GLU A CG  1 ? 
ATOM   898  C  CD  . GLU A 1 119 ? 28.984  15.118  25.543  1.000 17.047 0 119 GLU A CD  1 ? 
ATOM   899  O  OE1 . GLU A 1 119 ? 27.767  15.369  25.614  1.000 17.503 0 119 GLU A OE1 1 ? 
ATOM   900  O  OE2 . GLU A 1 119 ? 29.715  14.578  26.456  1.000 21.803 0 119 GLU A OE2 1 ? 
ATOM   901  N  N   . GLU A 1 120 ? 26.812  13.305  23.030  1.000 7.941  0 120 GLU A N   1 ? 
ATOM   902  C  CA  . GLU A 1 120 ? 26.039  12.260  23.689  1.000 8.787  0 120 GLU A CA  1 ? 
ATOM   903  C  C   . GLU A 1 120 ? 26.291  10.916  23.016  1.000 8.942  0 120 GLU A C   1 ? 
ATOM   904  O  O   . GLU A 1 120 ? 26.473  9.887   23.710  1.000 9.053  0 120 GLU A O   1 ? 
ATOM   905  C  CB  . GLU A 1 120 ? 24.549  12.610  23.646  1.000 9.275  0 120 GLU A CB  1 ? 
ATOM   906  C  CG  . GLU A 1 120 ? 24.199  13.732  24.634  1.000 10.529 0 120 GLU A CG  1 ? 
ATOM   907  C  CD  . GLU A 1 120 ? 22.860  14.398  24.433  1.000 14.038 0 120 GLU A CD  1 ? 
ATOM   908  O  OE1 . GLU A 1 120 ? 22.181  14.210  23.443  1.000 11.751 0 120 GLU A OE1 1 ? 
ATOM   909  O  OE2 . GLU A 1 120 ? 22.496  15.149  25.393  1.000 19.082 0 120 GLU A OE2 1 ? 
ATOM   910  N  N   . ILE A 1 121 ? 26.329  10.936  21.686  1.000 8.712  0 121 ILE A N   1 ? 
ATOM   911  C  CA  . ILE A 1 121 ? 26.540  9.703   20.934  1.000 7.908  0 121 ILE A CA  1 ? 
ATOM   912  C  C   . ILE A 1 121 ? 27.939  9.126   21.148  1.000 8.145  0 121 ILE A C   1 ? 
ATOM   913  O  O   . ILE A 1 121 ? 28.082  7.908   21.188  1.000 8.744  0 121 ILE A O   1 ? 
ATOM   914  C  CB  . ILE A 1 121 ? 26.222  9.972   19.448  1.000 8.157  0 121 ILE A CB  1 ? 
ATOM   915  C  CG1 . ILE A 1 121 ? 24.730  10.127  19.294  1.000 9.175  0 121 ILE A CG1 1 ? 
ATOM   916  C  CG2 . ILE A 1 121 ? 26.788  8.888   18.551  1.000 9.464  0 121 ILE A CG2 1 ? 
ATOM   917  C  CD1 . ILE A 1 121 ? 24.259  10.734  17.979  1.000 10.598 0 121 ILE A CD1 1 ? 
ATOM   918  N  N   . ARG A 1 122 ? 28.936  9.990   21.381  1.000 8.306  0 122 ARG A N   1 ? 
ATOM   919  C  CA  . ARG A 1 122 ? 30.267  9.489   21.724  1.000 9.157  0 122 ARG A CA  1 ? 
ATOM   920  C  C   . ARG A 1 122 ? 30.184  8.702   23.034  1.000 8.855  0 122 ARG A C   1 ? 
ATOM   921  O  O   . ARG A 1 122 ? 30.746  7.571   23.157  1.000 9.042  0 122 ARG A O   1 ? 
ATOM   922  C  CB  . ARG A 1 122 ? 31.278  10.633  21.822  1.000 10.605 0 122 ARG A CB  1 ? 
ATOM   923  C  CG  . ARG A 1 122 ? 32.614  10.212  22.423  1.000 12.744 0 122 ARG A CG  1 ? 
ATOM   924  C  CD  . ARG A 1 122 ? 33.598  11.398  22.478  1.000 15.065 0 122 ARG A CD  1 ? 
ATOM   925  N  NE  . ARG A 1 122 ? 34.770  11.183  23.347  1.000 17.971 0 122 ARG A NE  1 ? 
ATOM   926  C  CZ  . ARG A 1 122 ? 35.714  10.351  23.022  1.000 22.749 0 122 ARG A CZ  1 ? 
ATOM   927  N  NH1 . ARG A 1 122 ? 35.735  9.757   21.841  1.000 24.662 0 122 ARG A NH1 1 ? 
ATOM   928  N  NH2 . ARG A 1 122 ? 36.649  10.133  23.931  1.000 26.111 0 122 ARG A NH2 1 ? 
ATOM   929  N  N   . ARG A 1 123 ? 29.508  9.256   24.051  1.000 8.615  0 123 ARG A N   1 ? 
ATOM   930  C  CA  . ARG A 1 123 ? 29.429  8.572   25.315  1.000 9.517  0 123 ARG A CA  1 ? 
ATOM   931  C  C   . ARG A 1 123 ? 28.676  7.257   25.151  1.000 8.704  0 123 ARG A C   1 ? 
ATOM   932  O  O   . ARG A 1 123 ? 29.050  6.216   25.715  1.000 8.592  0 123 ARG A O   1 ? 
ATOM   933  C  CB  . ARG A 1 123 ? 28.755  9.428   26.389  1.000 11.883 0 123 ARG A CB  1 ? 
ATOM   934  C  CG  . ARG A 1 123 ? 29.491  10.680  26.820  1.000 16.372 0 123 ARG A CG  1 ? 
ATOM   935  C  CD  . ARG A 1 123 ? 28.563  11.376  27.843  1.000 21.905 0 123 ARG A CD  1 ? 
ATOM   936  N  NE  . ARG A 1 123 ? 28.945  12.657  28.427  1.000 35.012 0 123 ARG A NE  1 ? 
ATOM   937  C  CZ  . ARG A 1 123 ? 28.141  13.727  28.572  1.000 46.191 0 123 ARG A CZ  1 ? 
ATOM   938  N  NH1 . ARG A 1 123 ? 26.959  13.794  27.954  1.000 44.233 0 123 ARG A NH1 1 ? 
ATOM   939  N  NH2 . ARG A 1 123 ? 28.577  14.771  29.279  1.000 49.133 0 123 ARG A NH2 1 ? 
ATOM   940  N  N   . ILE A 1 124 ? 27.595  7.282   24.372  1.000 7.339  0 124 ILE A N   1 ? 
ATOM   941  C  CA  . ILE A 1 124 ? 26.823  6.076   24.112  1.000 7.658  0 124 ILE A CA  1 ? 
ATOM   942  C  C   . ILE A 1 124 ? 27.705  5.042   23.442  1.000 7.568  0 124 ILE A C   1 ? 
ATOM   943  O  O   . ILE A 1 124 ? 27.684  3.870   23.833  1.000 7.971  0 124 ILE A O   1 ? 
ATOM   944  C  CB  . ILE A 1 124 ? 25.601  6.436   23.232  1.000 7.663  0 124 ILE A CB  1 ? 
ATOM   945  C  CG1 . ILE A 1 124 ? 24.604  7.256   24.027  1.000 8.260  0 124 ILE A CG1 1 ? 
ATOM   946  C  CG2 . ILE A 1 124 ? 24.978  5.175   22.663  1.000 9.507  0 124 ILE A CG2 1 ? 
ATOM   947  C  CD1 . ILE A 1 124 ? 23.520  7.938   23.207  1.000 9.089  0 124 ILE A CD1 1 ? 
ATOM   948  N  N   . SER A 1 125 ? 28.418  5.438   22.396  1.000 7.674  0 125 SER A N   1 ? 
ATOM   949  C  CA  A SER A 1 125 ? 29.250  4.528   21.622  0.500 8.634  0 125 SER A CA  1 ? 
ATOM   950  C  CA  B SER A 1 125 ? 29.207  4.483   21.632  0.500 8.834  0 125 SER A CA  1 ? 
ATOM   951  C  C   . SER A 1 125 ? 30.300  3.855   22.509  1.000 8.644  0 125 SER A C   1 ? 
ATOM   952  O  O   . SER A 1 125 ? 30.564  2.648   22.412  1.000 9.132  0 125 SER A O   1 ? 
ATOM   953  C  CB  A SER A 1 125 ? 29.919  5.315   20.535  0.500 8.336  0 125 SER A CB  1 ? 
ATOM   954  C  CB  B SER A 1 125 ? 29.770  5.167   20.418  0.500 8.852  0 125 SER A CB  1 ? 
ATOM   955  O  OG  A SER A 1 125 ? 28.989  5.754   19.558  0.500 8.143  0 125 SER A OG  1 ? 
ATOM   956  O  OG  B SER A 1 125 ? 30.482  4.250   19.588  0.500 9.706  0 125 SER A OG  1 ? 
ATOM   957  N  N   . GLN A 1 126 ? 30.937  4.660   23.356  1.000 9.137  0 126 GLN A N   1 ? 
ATOM   958  C  CA  . GLN A 1 126 ? 31.995  4.132   24.221  1.000 9.694  0 126 GLN A CA  1 ? 
ATOM   959  C  C   . GLN A 1 126 ? 31.406  3.201   25.280  1.000 9.007  0 126 GLN A C   1 ? 
ATOM   960  O  O   . GLN A 1 126 ? 31.982  2.172   25.617  1.000 9.371  0 126 GLN A O   1 ? 
ATOM   961  C  CB  . GLN A 1 126 ? 32.711  5.284   24.899  1.000 12.555 0 126 GLN A CB  1 ? 
ATOM   962  C  CG  . GLN A 1 126 ? 33.520  6.167   23.976  1.000 16.927 0 126 GLN A CG  1 ? 
ATOM   963  C  CD  . GLN A 1 126 ? 34.239  7.241   24.771  1.000 25.467 0 126 GLN A CD  1 ? 
ATOM   964  O  OE1 . GLN A 1 126 ? 33.620  7.960   25.571  1.000 39.976 0 126 GLN A OE1 1 ? 
ATOM   965  N  NE2 . GLN A 1 126 ? 35.546  7.296   24.618  1.000 34.506 0 126 GLN A NE2 1 ? 
ATOM   966  N  N   . THR A 1 127 ? 30.260  3.544   25.849  1.000 9.057  0 127 THR A N   1 ? 
ATOM   967  C  CA  . THR A 1 127 ? 29.675  2.725   26.905  1.000 8.993  0 127 THR A CA  1 ? 
ATOM   968  C  C   . THR A 1 127 ? 29.125  1.435   26.301  1.000 8.278  0 127 THR A C   1 ? 
ATOM   969  O  O   . THR A 1 127 ? 29.243  0.366   26.939  1.000 9.281  0 127 THR A O   1 ? 
ATOM   970  C  CB  . THR A 1 127 ? 28.583  3.519   27.631  1.000 9.841  0 127 THR A CB  1 ? 
ATOM   971  O  OG1 . THR A 1 127 ? 29.196  4.677   28.234  1.000 11.109 0 127 THR A OG1 1 ? 
ATOM   972  C  CG2 . THR A 1 127 ? 27.859  2.730   28.709  1.000 9.747  0 127 THR A CG2 1 ? 
ATOM   973  N  N   . TYR A 1 128 ? 28.542  1.481   25.085  1.000 7.981  0 128 TYR A N   1 ? 
ATOM   974  C  CA  . TYR A 1 128 ? 28.081  0.268   24.434  1.000 7.909  0 128 TYR A CA  1 ? 
ATOM   975  C  C   . TYR A 1 128 ? 29.250  -0.700  24.269  1.000 7.742  0 128 TYR A C   1 ? 
ATOM   976  O  O   . TYR A 1 128 ? 29.139  -1.901  24.554  1.000 8.089  0 128 TYR A O   1 ? 
ATOM   977  C  CB  . TYR A 1 128 ? 27.465  0.682   23.090  1.000 7.552  0 128 TYR A CB  1 ? 
ATOM   978  C  CG  . TYR A 1 128 ? 26.788  -0.397  22.260  1.000 8.082  0 128 TYR A CG  1 ? 
ATOM   979  C  CD1 . TYR A 1 128 ? 27.518  -1.256  21.452  1.000 8.005  0 128 TYR A CD1 1 ? 
ATOM   980  C  CD2 . TYR A 1 128 ? 25.400  -0.512  22.243  1.000 8.135  0 128 TYR A CD2 1 ? 
ATOM   981  C  CE1 . TYR A 1 128 ? 26.900  -2.192  20.657  1.000 7.738  0 128 TYR A CE1 1 ? 
ATOM   982  C  CE2 . TYR A 1 128 ? 24.768  -1.458  21.445  1.000 7.972  0 128 TYR A CE2 1 ? 
ATOM   983  C  CZ  . TYR A 1 128 ? 25.523  -2.270  20.641  1.000 7.908  0 128 TYR A CZ  1 ? 
ATOM   984  O  OH  . TYR A 1 128 ? 24.897  -3.219  19.838  1.000 9.892  0 128 TYR A OH  1 ? 
ATOM   985  N  N   . GLN A 1 129 ? 30.372  -0.194  23.771  1.000 8.437  0 129 GLN A N   1 ? 
ATOM   986  C  CA  . GLN A 1 129 ? 31.573  -1.013  23.581  1.000 8.164  0 129 GLN A CA  1 ? 
ATOM   987  C  C   . GLN A 1 129 ? 32.033  -1.639  24.903  1.000 8.596  0 129 GLN A C   1 ? 
ATOM   988  O  O   . GLN A 1 129 ? 32.358  -2.848  24.990  1.000 8.899  0 129 GLN A O   1 ? 
ATOM   989  C  CB  . GLN A 1 129 ? 32.701  -0.176  22.996  1.000 9.885  0 129 GLN A CB  1 ? 
ATOM   990  C  CG  . GLN A 1 129 ? 33.864  -1.037  22.506  1.000 10.512 0 129 GLN A CG  1 ? 
ATOM   991  C  CD  . GLN A 1 129 ? 33.818  -1.388  21.047  1.000 12.046 0 129 GLN A CD  1 ? 
ATOM   992  O  OE1 . GLN A 1 129 ? 34.134  -2.545  20.636  1.000 16.075 0 129 GLN A OE1 1 ? 
ATOM   993  N  NE2 . GLN A 1 129 ? 33.402  -0.431  20.236  1.000 11.292 0 129 GLN A NE2 1 ? 
ATOM   994  N  N   . GLN A 1 130 ? 32.103  -0.825  25.958  1.000 8.391  0 130 GLN A N   1 ? 
ATOM   995  C  CA  . GLN A 1 130 ? 32.592  -1.311  27.233  1.000 9.845  0 130 GLN A CA  1 ? 
ATOM   996  C  C   . GLN A 1 130 ? 31.670  -2.363  27.826  1.000 9.601  0 130 GLN A C   1 ? 
ATOM   997  O  O   . GLN A 1 130 ? 32.173  -3.353  28.426  1.000 10.268 0 130 GLN A O   1 ? 
ATOM   998  C  CB  . GLN A 1 130 ? 32.724  -0.161  28.221  1.000 13.367 0 130 GLN A CB  1 ? 
ATOM   999  C  CG  . GLN A 1 130 ? 33.255  -0.649  29.549  1.000 20.206 0 130 GLN A CG  1 ? 
ATOM   1000 C  CD  . GLN A 1 130 ? 33.246  0.421   30.610  1.000 27.850 0 130 GLN A CD  1 ? 
ATOM   1001 O  OE1 . GLN A 1 130 ? 33.690  1.548   30.340  1.000 28.665 0 130 GLN A OE1 1 ? 
ATOM   1002 N  NE2 . GLN A 1 130 ? 32.704  0.068   31.779  1.000 30.697 0 130 GLN A NE2 1 ? 
ATOM   1003 N  N   . GLN A 1 131 ? 30.364  -2.199  27.713  1.000 8.920  0 131 GLN A N   1 ? 
ATOM   1004 C  CA  . GLN A 1 131 ? 29.401  -3.096  28.346  1.000 9.906  0 131 GLN A CA  1 ? 
ATOM   1005 C  C   . GLN A 1 131 ? 29.306  -4.415  27.606  1.000 10.655 0 131 GLN A C   1 ? 
ATOM   1006 O  O   . GLN A 1 131 ? 29.184  -5.449  28.240  1.000 12.733 0 131 GLN A O   1 ? 
ATOM   1007 C  CB  . GLN A 1 131 ? 28.008  -2.472  28.278  1.000 11.808 0 131 GLN A CB  1 ? 
ATOM   1008 C  CG  . GLN A 1 131 ? 27.844  -1.285  29.220  1.000 12.985 0 131 GLN A CG  1 ? 
ATOM   1009 C  CD  . GLN A 1 131 ? 27.771  -1.635  30.686  1.000 16.723 0 131 GLN A CD  1 ? 
ATOM   1010 O  OE1 . GLN A 1 131 ? 28.555  -1.133  31.491  1.000 25.454 0 131 GLN A OE1 1 ? 
ATOM   1011 N  NE2 . GLN A 1 131 ? 26.793  -2.431  31.025  1.000 17.489 0 131 GLN A NE2 1 ? 
ATOM   1012 N  N   . TYR A 1 132 ? 29.267  -4.391  26.291  1.000 9.890  0 132 TYR A N   1 ? 
ATOM   1013 C  CA  . TYR A 1 132 ? 28.925  -5.563  25.503  1.000 9.925  0 132 TYR A CA  1 ? 
ATOM   1014 C  C   . TYR A 1 132 ? 30.123  -6.155  24.794  1.000 10.222 0 132 TYR A C   1 ? 
ATOM   1015 O  O   . TYR A 1 132 ? 30.008  -7.274  24.290  1.000 11.385 0 132 TYR A O   1 ? 
ATOM   1016 C  CB  . TYR A 1 132 ? 27.856  -5.213  24.463  1.000 9.880  0 132 TYR A CB  1 ? 
ATOM   1017 C  CG  . TYR A 1 132 ? 26.597  -4.615  25.073  1.000 9.617  0 132 TYR A CG  1 ? 
ATOM   1018 C  CD1 . TYR A 1 132 ? 25.892  -5.279  26.074  1.000 10.216 0 132 TYR A CD1 1 ? 
ATOM   1019 C  CD2 . TYR A 1 132 ? 26.131  -3.363  24.702  1.000 9.931  0 132 TYR A CD2 1 ? 
ATOM   1020 C  CE1 . TYR A 1 132 ? 24.752  -4.733  26.639  1.000 10.440 0 132 TYR A CE1 1 ? 
ATOM   1021 C  CE2 . TYR A 1 132 ? 24.989  -2.817  25.249  1.000 10.470 0 132 TYR A CE2 1 ? 
ATOM   1022 C  CZ  . TYR A 1 132 ? 24.347  -3.467  26.268  1.000 10.238 0 132 TYR A CZ  1 ? 
ATOM   1023 O  OH  . TYR A 1 132 ? 23.211  -2.917  26.851  1.000 10.952 0 132 TYR A OH  1 ? 
ATOM   1024 N  N   . GLY A 1 133 ? 31.220  -5.424  24.650  1.000 9.169  0 133 GLY A N   1 ? 
ATOM   1025 C  CA  . GLY A 1 133 ? 32.337  -5.879  23.829  1.000 9.930  0 133 GLY A CA  1 ? 
ATOM   1026 C  C   . GLY A 1 133 ? 31.969  -6.059  22.377  1.000 9.478  0 133 GLY A C   1 ? 
ATOM   1027 O  O   . GLY A 1 133 ? 32.464  -6.960  21.697  1.000 9.884  0 133 GLY A O   1 ? 
ATOM   1028 N  N   . ARG A 1 134 ? 31.089  -5.151  21.897  1.000 10.169 0 134 ARG A N   1 ? 
ATOM   1029 C  CA  . ARG A 1 134 ? 30.629  -5.078  20.530  1.000 10.188 0 134 ARG A CA  1 ? 
ATOM   1030 C  C   . ARG A 1 134 ? 30.718  -3.627  20.118  1.000 9.297  0 134 ARG A C   1 ? 
ATOM   1031 O  O   . ARG A 1 134 ? 30.446  -2.748  20.934  1.000 9.460  0 134 ARG A O   1 ? 
ATOM   1032 C  CB  . ARG A 1 134 ? 29.115  -5.444  20.501  1.000 12.373 0 134 ARG A CB  1 ? 
ATOM   1033 C  CG  . ARG A 1 134 ? 28.746  -6.822  21.037  1.000 13.439 0 134 ARG A CG  1 ? 
ATOM   1034 C  CD  . ARG A 1 134 ? 27.319  -7.224  21.071  1.000 12.144 0 134 ARG A CD  1 ? 
ATOM   1035 N  NE  . ARG A 1 134 ? 26.741  -7.348  19.724  1.000 10.831 0 134 ARG A NE  1 ? 
ATOM   1036 C  CZ  . ARG A 1 134 ? 26.049  -8.370  19.272  1.000 11.194 0 134 ARG A CZ  1 ? 
ATOM   1037 N  NH1 . ARG A 1 134 ? 25.929  -9.474  20.007  1.000 13.700 0 134 ARG A NH1 1 ? 
ATOM   1038 N  NH2 . ARG A 1 134 ? 25.465  -8.293  18.079  1.000 12.267 0 134 ARG A NH2 1 ? 
ATOM   1039 N  N   . SER A 1 135 ? 31.088  -3.370  18.869  1.000 9.249  0 135 SER A N   1 ? 
ATOM   1040 C  CA  . SER A 1 135 ? 31.072  -2.043  18.264  1.000 9.932  0 135 SER A CA  1 ? 
ATOM   1041 C  C   . SER A 1 135 ? 29.648  -1.624  17.883  1.000 8.874  0 135 SER A C   1 ? 
ATOM   1042 O  O   . SER A 1 135 ? 29.019  -2.384  17.150  1.000 10.161 0 135 SER A O   1 ? 
ATOM   1043 C  CB  . SER A 1 135 ? 31.962  -2.099  17.042  1.000 11.803 0 135 SER A CB  1 ? 
ATOM   1044 O  OG  . SER A 1 135 ? 31.739  -1.021  16.172  1.000 11.342 0 135 SER A OG  1 ? 
ATOM   1045 N  N   . LEU A 1 136 ? 29.209  -0.456  18.351  1.000 8.642  0 136 LEU A N   1 ? 
ATOM   1046 C  CA  . LEU A 1 136 ? 27.920  0.053   17.928  1.000 8.545  0 136 LEU A CA  1 ? 
ATOM   1047 C  C   . LEU A 1 136 ? 27.858  0.190   16.413  1.000 8.313  0 136 LEU A C   1 ? 
ATOM   1048 O  O   . LEU A 1 136 ? 26.890  -0.239  15.781  1.000 8.186  0 136 LEU A O   1 ? 
ATOM   1049 C  CB  . LEU A 1 136 ? 27.670  1.385   18.616  1.000 9.404  0 136 LEU A CB  1 ? 
ATOM   1050 C  CG  . LEU A 1 136 ? 26.383  2.097   18.200  1.000 9.227  0 136 LEU A CG  1 ? 
ATOM   1051 C  CD1 . LEU A 1 136 ? 25.107  1.312   18.446  1.000 10.075 0 136 LEU A CD1 1 ? 
ATOM   1052 C  CD2 . LEU A 1 136 ? 26.284  3.449   18.854  1.000 10.245 0 136 LEU A CD2 1 ? 
ATOM   1053 N  N   . GLU A 1 137 ? 28.909  0.728   15.818  1.000 8.663  0 137 GLU A N   1 ? 
ATOM   1054 C  CA  . GLU A 1 137 ? 28.977  0.851   14.359  1.000 8.882  0 137 GLU A CA  1 ? 
ATOM   1055 C  C   . GLU A 1 137 ? 28.880  -0.504  13.666  1.000 7.904  0 137 GLU A C   1 ? 
ATOM   1056 O  O   . GLU A 1 137 ? 28.157  -0.658  12.701  1.000 8.959  0 137 GLU A O   1 ? 
ATOM   1057 C  CB  . GLU A 1 137 ? 30.253  1.536   13.884  1.000 10.312 0 137 GLU A CB  1 ? 
ATOM   1058 C  CG  . GLU A 1 137 ? 30.286  1.765   12.378  1.000 13.873 0 137 GLU A CG  1 ? 
ATOM   1059 C  CD  . GLU A 1 137 ? 31.387  2.591   11.809  1.000 19.557 0 137 GLU A CD  1 ? 
ATOM   1060 O  OE1 . GLU A 1 137 ? 31.691  3.656   12.390  1.000 24.019 0 137 GLU A OE1 1 ? 
ATOM   1061 O  OE2 . GLU A 1 137 ? 31.898  2.184   10.728  1.000 19.489 0 137 GLU A OE2 1 ? 
ATOM   1062 N  N   . ASP A 1 138 ? 29.600  -1.503  14.159  1.000 9.127  0 138 ASP A N   1 ? 
ATOM   1063 C  CA  . ASP A 1 138 ? 29.566  -2.817  13.518  1.000 9.854  0 138 ASP A CA  1 ? 
ATOM   1064 C  C   . ASP A 1 138 ? 28.162  -3.394  13.596  1.000 9.408  0 138 ASP A C   1 ? 
ATOM   1065 O  O   . ASP A 1 138 ? 27.680  -3.989  12.622  1.000 9.242  0 138 ASP A O   1 ? 
ATOM   1066 C  CB  . ASP A 1 138 ? 30.478  -3.855  14.168  1.000 12.799 0 138 ASP A CB  1 ? 
ATOM   1067 C  CG  . ASP A 1 138 ? 31.956  -3.693  13.980  1.000 18.133 0 138 ASP A CG  1 ? 
ATOM   1068 O  OD1 . ASP A 1 138 ? 32.311  -2.877  13.123  1.000 20.232 0 138 ASP A OD1 1 ? 
ATOM   1069 O  OD2 . ASP A 1 138 ? 32.711  -4.454  14.688  1.000 19.807 0 138 ASP A OD2 1 ? 
ATOM   1070 N  N   . ASP A 1 139 ? 27.491  -3.265  14.754  1.000 8.699  0 139 ASP A N   1 ? 
ATOM   1071 C  CA  . ASP A 1 139 ? 26.128  -3.798  14.866  1.000 8.942  0 139 ASP A CA  1 ? 
ATOM   1072 C  C   . ASP A 1 139 ? 25.164  -3.061  13.934  1.000 8.200  0 139 ASP A C   1 ? 
ATOM   1073 O  O   . ASP A 1 139 ? 24.320  -3.700  13.298  1.000 8.133  0 139 ASP A O   1 ? 
ATOM   1074 C  CB  . ASP A 1 139 ? 25.680  -3.796  16.331  1.000 9.181  0 139 ASP A CB  1 ? 
ATOM   1075 C  CG  . ASP A 1 139 ? 26.294  -4.923  17.136  1.000 10.309 0 139 ASP A CG  1 ? 
ATOM   1076 O  OD1 . ASP A 1 139 ? 26.727  -5.925  16.526  1.000 11.810 0 139 ASP A OD1 1 ? 
ATOM   1077 O  OD2 . ASP A 1 139 ? 26.321  -4.832  18.379  1.000 9.727  0 139 ASP A OD2 1 ? 
ATOM   1078 N  N   . ILE A 1 140 ? 25.263  -1.711  13.841  1.000 7.530  0 140 ILE A N   1 ? 
ATOM   1079 C  CA  . ILE A 1 140 ? 24.466  -0.975  12.859  1.000 8.101  0 140 ILE A CA  1 ? 
ATOM   1080 C  C   . ILE A 1 140 ? 24.705  -1.532  11.457  1.000 7.978  0 140 ILE A C   1 ? 
ATOM   1081 O  O   . ILE A 1 140 ? 23.755  -1.720  10.693  1.000 8.421  0 140 ILE A O   1 ? 
ATOM   1082 C  CB  . ILE A 1 140 ? 24.791  0.524   12.948  1.000 8.317  0 140 ILE A CB  1 ? 
ATOM   1083 C  CG1 . ILE A 1 140 ? 24.277  1.109   14.239  1.000 9.077  0 140 ILE A CG1 1 ? 
ATOM   1084 C  CG2 . ILE A 1 140 ? 24.250  1.293   11.748  1.000 8.994  0 140 ILE A CG2 1 ? 
ATOM   1085 C  CD1 . ILE A 1 140 ? 24.765  2.510   14.564  1.000 9.056  0 140 ILE A CD1 1 ? 
ATOM   1086 N  N   . ARG A 1 141 ? 25.977  -1.777  11.100  1.000 7.782  0 141 ARG A N   1 ? 
ATOM   1087 C  CA  . ARG A 1 141 ? 26.302  -2.230  9.729   1.000 8.020  0 141 ARG A CA  1 ? 
ATOM   1088 C  C   . ARG A 1 141 ? 25.907  -3.669  9.498   1.000 8.823  0 141 ARG A C   1 ? 
ATOM   1089 O  O   . ARG A 1 141 ? 25.825  -4.121  8.345   1.000 10.706 0 141 ARG A O   1 ? 
ATOM   1090 C  CB  . ARG A 1 141 ? 27.761  -1.982  9.416   1.000 8.375  0 141 ARG A CB  1 ? 
ATOM   1091 C  CG  . ARG A 1 141 ? 28.088  -0.497  9.381   1.000 9.117  0 141 ARG A CG  1 ? 
ATOM   1092 C  CD  . ARG A 1 141 ? 29.549  -0.115  9.117   1.000 11.721 0 141 ARG A CD  1 ? 
ATOM   1093 N  NE  . ARG A 1 141 ? 29.869  -0.371  7.718   1.000 15.030 0 141 ARG A NE  1 ? 
ATOM   1094 C  CZ  . ARG A 1 141 ? 31.059  -0.110  7.165   1.000 15.769 0 141 ARG A CZ  1 ? 
ATOM   1095 N  NH1 . ARG A 1 141 ? 32.007  0.396   7.892   1.000 17.168 0 141 ARG A NH1 1 ? 
ATOM   1096 N  NH2 . ARG A 1 141 ? 31.266  -0.388  5.901   1.000 19.240 0 141 ARG A NH2 1 ? 
ATOM   1097 N  N   . SER A 1 142 ? 25.695  -4.419  10.557  1.000 7.949  0 142 SER A N   1 ? 
ATOM   1098 C  CA  . SER A 1 142 ? 25.229  -5.809  10.475  1.000 8.484  0 142 SER A CA  1 ? 
ATOM   1099 C  C   . SER A 1 142 ? 23.715  -5.923  10.380  1.000 8.849  0 142 SER A C   1 ? 
ATOM   1100 O  O   . SER A 1 142 ? 23.210  -6.933  9.871   1.000 8.795  0 142 SER A O   1 ? 
ATOM   1101 C  CB  . SER A 1 142 ? 25.694  -6.610  11.662  1.000 10.020 0 142 SER A CB  1 ? 
ATOM   1102 O  OG  . SER A 1 142 ? 27.115  -6.575  11.749  1.000 11.036 0 142 SER A OG  1 ? 
ATOM   1103 N  N   . ASP A 1 143 ? 22.971  -4.928  10.894  1.000 8.189  0 143 ASP A N   1 ? 
ATOM   1104 C  CA  . ASP A 1 143 ? 21.538  -5.016  11.061  1.000 8.726  0 143 ASP A CA  1 ? 
ATOM   1105 C  C   . ASP A 1 143 ? 20.736  -4.066  10.183  1.000 8.447  0 143 ASP A C   1 ? 
ATOM   1106 O  O   . ASP A 1 143 ? 19.509  -4.155  10.157  1.000 9.978  0 143 ASP A O   1 ? 
ATOM   1107 C  CB  . ASP A 1 143 ? 21.148  -4.842  12.521  1.000 9.890  0 143 ASP A CB  1 ? 
ATOM   1108 C  CG  . ASP A 1 143 ? 21.574  -6.010  13.407  1.000 11.434 0 143 ASP A CG  1 ? 
ATOM   1109 O  OD1 . ASP A 1 143 ? 22.126  -7.042  12.868  1.000 12.917 0 143 ASP A OD1 1 ? 
ATOM   1110 O  OD2 . ASP A 1 143 ? 21.292  -5.960  14.589  1.000 13.126 0 143 ASP A OD2 1 ? 
ATOM   1111 N  N   . THR A 1 144 ? 21.417  -3.168  9.503   1.000 7.912  0 144 THR A N   1 ? 
ATOM   1112 C  CA  . THR A 1 144 ? 20.805  -2.263  8.547   1.000 8.537  0 144 THR A CA  1 ? 
ATOM   1113 C  C   . THR A 1 144 ? 21.671  -2.232  7.298   1.000 9.425  0 144 THR A C   1 ? 
ATOM   1114 O  O   . THR A 1 144 ? 22.852  -2.523  7.367   1.000 9.085  0 144 THR A O   1 ? 
ATOM   1115 C  CB  . THR A 1 144 ? 20.660  -0.875  9.168   1.000 9.180  0 144 THR A CB  1 ? 
ATOM   1116 O  OG1 . THR A 1 144 ? 21.899  -0.191  9.290   1.000 9.140  0 144 THR A OG1 1 ? 
ATOM   1117 C  CG2 . THR A 1 144 ? 19.897  -0.904  10.477  1.000 9.837  0 144 THR A CG2 1 ? 
ATOM   1118 N  N   . SER A 1 145 ? 21.060  -1.786  6.172   1.000 8.716  0 145 SER A N   1 ? 
ATOM   1119 C  CA  . SER A 1 145 ? 21.747  -1.851  4.881   1.000 9.762  0 145 SER A CA  1 ? 
ATOM   1120 C  C   . SER A 1 145 ? 21.491  -0.585  4.059   1.000 9.338  0 145 SER A C   1 ? 
ATOM   1121 O  O   . SER A 1 145 ? 20.621  0.223   4.345   1.000 9.705  0 145 SER A O   1 ? 
ATOM   1122 C  CB  . SER A 1 145 ? 21.289  -3.048  4.088   1.000 10.863 0 145 SER A CB  1 ? 
ATOM   1123 O  OG  . SER A 1 145 ? 21.683  -4.266  4.752   1.000 11.913 0 145 SER A OG  1 ? 
ATOM   1124 N  N   . PHE A 1 146 ? 22.307  -0.458  3.031   1.000 9.803  0 146 PHE A N   1 ? 
ATOM   1125 C  CA  . PHE A 1 146 ? 22.093  0.495   1.936   1.000 9.807  0 146 PHE A CA  1 ? 
ATOM   1126 C  C   . PHE A 1 146 ? 22.068  1.917   2.493   1.000 9.668  0 146 PHE A C   1 ? 
ATOM   1127 O  O   . PHE A 1 146 ? 22.866  2.271   3.352   1.000 10.050 0 146 PHE A O   1 ? 
ATOM   1128 C  CB  . PHE A 1 146 ? 20.843  0.097   1.133   1.000 12.125 0 146 PHE A CB  1 ? 
ATOM   1129 C  CG  . PHE A 1 146 ? 20.890  -1.338  0.632   1.000 13.656 0 146 PHE A CG  1 ? 
ATOM   1130 C  CD1 . PHE A 1 146 ? 21.993  -1.787  -0.065  1.000 16.492 0 146 PHE A CD1 1 ? 
ATOM   1131 C  CD2 . PHE A 1 146 ? 19.897  -2.223  0.971   1.000 14.991 0 146 PHE A CD2 1 ? 
ATOM   1132 C  CE1 . PHE A 1 146 ? 22.088  -3.112  -0.476  1.000 19.778 0 146 PHE A CE1 1 ? 
ATOM   1133 C  CE2 . PHE A 1 146 ? 19.994  -3.566  0.527   1.000 16.764 0 146 PHE A CE2 1 ? 
ATOM   1134 C  CZ  . PHE A 1 146 ? 21.091  -3.972  -0.194  1.000 17.313 0 146 PHE A CZ  1 ? 
ATOM   1135 N  N   . MET A 1 147 ? 21.221  2.780   1.916   1.000 9.263  0 147 MET A N   1 ? 
ATOM   1136 C  CA  . MET A 1 147 ? 21.304  4.197   2.260   1.000 10.140 0 147 MET A CA  1 ? 
ATOM   1137 C  C   . MET A 1 147 ? 20.880  4.441   3.710   1.000 9.102  0 147 MET A C   1 ? 
ATOM   1138 O  O   . MET A 1 147 ? 21.407  5.343   4.385   1.000 9.205  0 147 MET A O   1 ? 
ATOM   1139 C  CB  . MET A 1 147 ? 20.449  5.031   1.291   1.000 11.205 0 147 MET A CB  1 ? 
ATOM   1140 C  CG  . MET A 1 147 ? 21.010  5.029   -0.125  1.000 12.944 0 147 MET A CG  1 ? 
ATOM   1141 S  SD  . MET A 1 147 ? 22.648  5.723   -0.279  1.000 15.305 0 147 MET A SD  1 ? 
ATOM   1142 C  CE  . MET A 1 147 ? 22.355  7.402   0.298   1.000 16.915 0 147 MET A CE  1 ? 
ATOM   1143 N  N   . PHE A 1 148 ? 19.922  3.687   4.242   1.000 9.026  0 148 PHE A N   1 ? 
ATOM   1144 C  CA  . PHE A 1 148 ? 19.520  3.795   5.642   1.000 8.608  0 148 PHE A CA  1 ? 
ATOM   1145 C  C   . PHE A 1 148 ? 20.731  3.531   6.539   1.000 7.965  0 148 PHE A C   1 ? 
ATOM   1146 O  O   . PHE A 1 148 ? 21.036  4.288   7.490   1.000 8.433  0 148 PHE A O   1 ? 
ATOM   1147 C  CB  . PHE A 1 148 ? 18.406  2.793   5.936   1.000 8.772  0 148 PHE A CB  1 ? 
ATOM   1148 C  CG  . PHE A 1 148 ? 17.964  2.750   7.371   1.000 9.202  0 148 PHE A CG  1 ? 
ATOM   1149 C  CD1 . PHE A 1 148 ? 17.697  3.926   8.061   1.000 9.357  0 148 PHE A CD1 1 ? 
ATOM   1150 C  CD2 . PHE A 1 148 ? 17.785  1.551   8.056   1.000 9.106  0 148 PHE A CD2 1 ? 
ATOM   1151 C  CE1 . PHE A 1 148 ? 17.260  3.891   9.362   1.000 10.308 0 148 PHE A CE1 1 ? 
ATOM   1152 C  CE2 . PHE A 1 148 ? 17.388  1.541   9.388   1.000 9.599  0 148 PHE A CE2 1 ? 
ATOM   1153 C  CZ  . PHE A 1 148 ? 17.074  2.699   10.024  1.000 9.304  0 148 PHE A CZ  1 ? 
ATOM   1154 N  N   . GLN A 1 149 ? 21.479  2.473   6.281   1.000 7.700  0 149 GLN A N   1 ? 
ATOM   1155 C  CA  . GLN A 1 149 ? 22.681  2.208   7.047   1.000 9.303  0 149 GLN A CA  1 ? 
ATOM   1156 C  C   . GLN A 1 149 ? 23.643  3.378   7.019   1.000 8.595  0 149 GLN A C   1 ? 
ATOM   1157 O  O   . GLN A 1 149 ? 24.219  3.759   8.034   1.000 8.535  0 149 GLN A O   1 ? 
ATOM   1158 C  CB  . GLN A 1 149 ? 23.389  0.992   6.457   1.000 8.912  0 149 GLN A CB  1 ? 
ATOM   1159 C  CG  . GLN A 1 149 ? 24.634  0.595   7.245   1.000 10.177 0 149 GLN A CG  1 ? 
ATOM   1160 C  CD  . GLN A 1 149 ? 25.570  -0.303  6.489   1.000 11.405 0 149 GLN A CD  1 ? 
ATOM   1161 O  OE1 . GLN A 1 149 ? 25.323  -1.514  6.306   1.000 13.037 0 149 GLN A OE1 1 ? 
ATOM   1162 N  NE2 . GLN A 1 149 ? 26.634  0.290   5.995   1.000 12.118 0 149 GLN A NE2 1 ? 
ATOM   1163 N  N   . ARG A 1 150 ? 23.820  3.994   5.851   1.000 8.613  0 150 ARG A N   1 ? 
ATOM   1164 C  CA  . ARG A 1 150 ? 24.765  5.099   5.727   1.000 9.400  0 150 ARG A CA  1 ? 
ATOM   1165 C  C   . ARG A 1 150 ? 24.349  6.287   6.606   1.000 8.447  0 150 ARG A C   1 ? 
ATOM   1166 O  O   . ARG A 1 150 ? 25.216  6.900   7.218   1.000 9.046  0 150 ARG A O   1 ? 
ATOM   1167 C  CB  . ARG A 1 150 ? 24.937  5.541   4.281   1.000 9.968  0 150 ARG A CB  1 ? 
ATOM   1168 C  CG  . ARG A 1 150 ? 25.573  4.434   3.452   1.000 11.731 0 150 ARG A CG  1 ? 
ATOM   1169 C  CD  . ARG A 1 150 ? 26.017  4.859   2.062   1.000 12.293 0 150 ARG A CD  1 ? 
ATOM   1170 N  NE  . ARG A 1 150 ? 26.992  5.938   2.113   1.000 11.967 0 150 ARG A NE  1 ? 
ATOM   1171 C  CZ  . ARG A 1 150 ? 27.355  6.658   1.055   1.000 10.681 0 150 ARG A CZ  1 ? 
ATOM   1172 N  NH1 . ARG A 1 150 ? 26.828  6.367   -0.100  1.000 12.970 0 150 ARG A NH1 1 ? 
ATOM   1173 N  NH2 . ARG A 1 150 ? 28.153  7.702   1.233   1.000 11.471 0 150 ARG A NH2 1 ? 
ATOM   1174 N  N   . VAL A 1 151 ? 23.059  6.565   6.697   1.000 7.560  0 151 VAL A N   1 ? 
ATOM   1175 C  CA  . VAL A 1 151 ? 22.590  7.636   7.575   1.000 7.627  0 151 VAL A CA  1 ? 
ATOM   1176 C  C   . VAL A 1 151 ? 22.921  7.289   9.019   1.000 8.069  0 151 VAL A C   1 ? 
ATOM   1177 O  O   . VAL A 1 151 ? 23.478  8.117   9.755   1.000 7.649  0 151 VAL A O   1 ? 
ATOM   1178 C  CB  . VAL A 1 151 ? 21.085  7.916   7.412   1.000 8.411  0 151 VAL A CB  1 ? 
ATOM   1179 C  CG1 . VAL A 1 151 ? 20.610  8.878   8.484   1.000 8.161  0 151 VAL A CG1 1 ? 
ATOM   1180 C  CG2 . VAL A 1 151 ? 20.717  8.449   6.019   1.000 8.881  0 151 VAL A CG2 1 ? 
ATOM   1181 N  N   . LEU A 1 152 ? 22.597  6.056   9.462   1.000 7.558  0 152 LEU A N   1 ? 
ATOM   1182 C  CA  . LEU A 1 152 ? 22.849  5.704   10.857  1.000 7.417  0 152 LEU A CA  1 ? 
ATOM   1183 C  C   . LEU A 1 152 ? 24.340  5.686   11.167  1.000 7.917  0 152 LEU A C   1 ? 
ATOM   1184 O  O   . LEU A 1 152 ? 24.731  6.132   12.246  1.000 8.685  0 152 LEU A O   1 ? 
ATOM   1185 C  CB  . LEU A 1 152 ? 22.214  4.361   11.187  1.000 7.890  0 152 LEU A CB  1 ? 
ATOM   1186 C  CG  . LEU A 1 152 ? 20.695  4.255   11.082  1.000 8.453  0 152 LEU A CG  1 ? 
ATOM   1187 C  CD1 . LEU A 1 152 ? 20.296  2.862   11.607  1.000 9.564  0 152 LEU A CD1 1 ? 
ATOM   1188 C  CD2 . LEU A 1 152 ? 19.951  5.376   11.794  1.000 9.478  0 152 LEU A CD2 1 ? 
ATOM   1189 N  N   . VAL A 1 153 ? 25.167  5.199   10.256  1.000 7.362  0 153 VAL A N   1 ? 
ATOM   1190 C  CA  . VAL A 1 153 ? 26.604  5.204   10.510  1.000 8.202  0 153 VAL A CA  1 ? 
ATOM   1191 C  C   . VAL A 1 153 ? 27.122  6.633   10.660  1.000 8.972  0 153 VAL A C   1 ? 
ATOM   1192 O  O   . VAL A 1 153 ? 27.881  6.960   11.555  1.000 9.222  0 153 VAL A O   1 ? 
ATOM   1193 C  CB  . VAL A 1 153 ? 27.363  4.448   9.397   1.000 8.367  0 153 VAL A CB  1 ? 
ATOM   1194 C  CG1 . VAL A 1 153 ? 28.862  4.657   9.508   1.000 10.091 0 153 VAL A CG1 1 ? 
ATOM   1195 C  CG2 . VAL A 1 153 ? 27.064  2.963   9.519   1.000 9.130  0 153 VAL A CG2 1 ? 
ATOM   1196 N  N   . SER A 1 154 ? 26.684  7.524   9.747   1.000 8.203  0 154 SER A N   1 ? 
ATOM   1197 C  CA  . SER A 1 154 ? 27.106  8.912   9.814   1.000 7.937  0 154 SER A CA  1 ? 
ATOM   1198 C  C   . SER A 1 154 ? 26.724  9.494   11.175  1.000 7.504  0 154 SER A C   1 ? 
ATOM   1199 O  O   . SER A 1 154 ? 27.532  10.152  11.862  1.000 8.016  0 154 SER A O   1 ? 
ATOM   1200 C  CB  . SER A 1 154 ? 26.458  9.725   8.683   1.000 8.317  0 154 SER A CB  1 ? 
ATOM   1201 O  OG  . SER A 1 154 ? 26.878  11.067  8.815   1.000 9.539  0 154 SER A OG  1 ? 
ATOM   1202 N  N   . LEU A 1 155 ? 25.452  9.321   11.590  1.000 7.617  0 155 LEU A N   1 ? 
ATOM   1203 C  CA  . LEU A 1 155 ? 25.022  9.877   12.868  1.000 7.665  0 155 LEU A CA  1 ? 
ATOM   1204 C  C   . LEU A 1 155 ? 25.842  9.277   14.015  1.000 8.176  0 155 LEU A C   1 ? 
ATOM   1205 O  O   . LEU A 1 155 ? 26.199  9.971   14.973  1.000 9.019  0 155 LEU A O   1 ? 
ATOM   1206 C  CB  . LEU A 1 155 ? 23.528  9.637   13.047  1.000 8.356  0 155 LEU A CB  1 ? 
ATOM   1207 C  CG  . LEU A 1 155 ? 22.586  10.370  12.084  1.000 8.289  0 155 LEU A CG  1 ? 
ATOM   1208 C  CD1 . LEU A 1 155 ? 21.142  9.859   12.242  1.000 8.751  0 155 LEU A CD1 1 ? 
ATOM   1209 C  CD2 . LEU A 1 155 ? 22.622  11.886  12.286  1.000 9.170  0 155 LEU A CD2 1 ? 
ATOM   1210 N  N   . SER A 1 156 ? 26.151  7.978   13.942  1.000 8.719  0 156 SER A N   1 ? 
ATOM   1211 C  CA  . SER A 1 156 ? 26.869  7.276   15.016  1.000 8.625  0 156 SER A CA  1 ? 
ATOM   1212 C  C   . SER A 1 156 ? 28.299  7.780   15.156  1.000 9.664  0 156 SER A C   1 ? 
ATOM   1213 O  O   . SER A 1 156 ? 28.918  7.580   16.202  1.000 9.908  0 156 SER A O   1 ? 
ATOM   1214 C  CB  . SER A 1 156 ? 26.834  5.740   14.794  1.000 9.977  0 156 SER A CB  1 ? 
ATOM   1215 O  OG  . SER A 1 156 ? 27.784  5.359   13.831  1.000 12.284 0 156 SER A OG  1 ? 
ATOM   1216 N  N   . ALA A 1 157 ? 28.860  8.377   14.103  1.000 8.644  0 157 ALA A N   1 ? 
ATOM   1217 C  CA  . ALA A 1 157 ? 30.243  8.826   14.080  1.000 9.744  0 157 ALA A CA  1 ? 
ATOM   1218 C  C   . ALA A 1 157 ? 30.359  10.246  14.602  1.000 10.320 0 157 ALA A C   1 ? 
ATOM   1219 O  O   . ALA A 1 157 ? 31.458  10.680  14.924  1.000 11.801 0 157 ALA A O   1 ? 
ATOM   1220 C  CB  . ALA A 1 157 ? 30.821  8.716   12.675  1.000 10.695 0 157 ALA A CB  1 ? 
ATOM   1221 N  N   . GLY A 1 158 ? 29.252  11.009  14.632  1.000 10.162 0 158 GLY A N   1 ? 
ATOM   1222 C  CA  . GLY A 1 158 ? 29.323  12.314  15.290  1.000 10.117 0 158 GLY A CA  1 ? 
ATOM   1223 C  C   . GLY A 1 158 ? 30.096  13.388  14.518  1.000 10.352 0 158 GLY A C   1 ? 
ATOM   1224 O  O   . GLY A 1 158 ? 30.520  14.336  15.182  1.000 11.111 0 158 GLY A O   1 ? 
ATOM   1225 N  N   . GLY A 1 159 ? 30.225  13.271  13.192  1.000 10.676 0 159 GLY A N   1 ? 
ATOM   1226 C  CA  . GLY A 1 159 ? 31.108  14.118  12.404  1.000 10.770 0 159 GLY A CA  1 ? 
ATOM   1227 C  C   . GLY A 1 159 ? 30.454  15.348  11.769  1.000 10.938 0 159 GLY A C   1 ? 
ATOM   1228 O  O   . GLY A 1 159 ? 31.148  16.028  11.009  1.000 12.493 0 159 GLY A O   1 ? 
ATOM   1229 N  N   . ARG A 1 160 ? 29.209  15.636  12.089  1.000 10.129 0 160 ARG A N   1 ? 
ATOM   1230 C  CA  . ARG A 1 160 ? 28.530  16.780  11.490  1.000 10.538 0 160 ARG A CA  1 ? 
ATOM   1231 C  C   . ARG A 1 160 ? 29.334  18.062  11.737  1.000 9.862  0 160 ARG A C   1 ? 
ATOM   1232 O  O   . ARG A 1 160 ? 29.919  18.253  12.805  1.000 11.477 0 160 ARG A O   1 ? 
ATOM   1233 C  CB  . ARG A 1 160 ? 27.156  16.960  12.149  1.000 11.449 0 160 ARG A CB  1 ? 
ATOM   1234 C  CG  . ARG A 1 160 ? 26.283  18.026  11.523  1.000 12.025 0 160 ARG A CG  1 ? 
ATOM   1235 C  CD  . ARG A 1 160 ? 25.022  18.148  12.256  1.000 10.800 0 160 ARG A CD  1 ? 
ATOM   1236 N  NE  . ARG A 1 160 ? 24.144  17.000  12.135  1.000 10.824 0 160 ARG A NE  1 ? 
ATOM   1237 C  CZ  . ARG A 1 160 ? 23.534  16.669  11.036  1.000 10.230 0 160 ARG A CZ  1 ? 
ATOM   1238 N  NH1 . ARG A 1 160 ? 23.627  17.450  9.956   1.000 9.815  0 160 ARG A NH1 1 ? 
ATOM   1239 N  NH2 . ARG A 1 160 ? 22.787  15.600  10.973  1.000 10.040 0 160 ARG A NH2 1 ? 
ATOM   1240 N  N   . ASP A 1 161 ? 29.276  18.998  10.792  1.000 9.166  0 161 ASP A N   1 ? 
ATOM   1241 C  CA  . ASP A 1 161 ? 29.806  20.340  10.999  1.000 9.174  0 161 ASP A CA  1 ? 
ATOM   1242 C  C   . ASP A 1 161 ? 29.064  20.982  12.166  1.000 8.922  0 161 ASP A C   1 ? 
ATOM   1243 O  O   . ASP A 1 161 ? 27.898  20.784  12.395  1.000 8.919  0 161 ASP A O   1 ? 
ATOM   1244 C  CB  . ASP A 1 161 ? 29.555  21.188  9.766   1.000 10.138 0 161 ASP A CB  1 ? 
ATOM   1245 C  CG  . ASP A 1 161 ? 30.295  20.806  8.504   1.000 12.449 0 161 ASP A CG  1 ? 
ATOM   1246 O  OD1 . ASP A 1 161 ? 31.238  20.021  8.605   1.000 14.431 0 161 ASP A OD1 1 ? 
ATOM   1247 O  OD2 . ASP A 1 161 ? 29.922  21.350  7.425   1.000 12.354 0 161 ASP A OD2 1 ? 
ATOM   1248 N  N   . GLU A 1 162 ? 29.790  21.806  12.933  1.000 9.005  0 162 GLU A N   1 ? 
ATOM   1249 C  CA  . GLU A 1 162 ? 29.298  22.488  14.119  1.000 10.037 0 162 GLU A CA  1 ? 
ATOM   1250 C  C   . GLU A 1 162 ? 29.541  23.987  14.018  1.000 10.112 0 162 GLU A C   1 ? 
ATOM   1251 O  O   . GLU A 1 162 ? 30.188  24.489  13.091  1.000 11.544 0 162 GLU A O   1 ? 
ATOM   1252 C  CB  . GLU A 1 162 ? 29.948  21.874  15.367  1.000 10.768 0 162 GLU A CB  1 ? 
ATOM   1253 C  CG  . GLU A 1 162 ? 29.628  20.387  15.533  1.000 11.176 0 162 GLU A CG  1 ? 
ATOM   1254 C  CD  . GLU A 1 162 ? 28.185  20.071  15.814  1.000 13.369 0 162 GLU A CD  1 ? 
ATOM   1255 O  OE1 . GLU A 1 162 ? 27.334  20.910  16.050  1.000 13.936 0 162 GLU A OE1 1 ? 
ATOM   1256 O  OE2 . GLU A 1 162 ? 27.888  18.812  15.739  1.000 14.810 0 162 GLU A OE2 1 ? 
ATOM   1257 N  N   . GLY A 1 163 ? 29.027  24.700  15.018  1.000 9.912  0 163 GLY A N   1 ? 
ATOM   1258 C  CA  . GLY A 1 163 ? 28.980  26.140  14.913  1.000 9.932  0 163 GLY A CA  1 ? 
ATOM   1259 C  C   . GLY A 1 163 ? 27.846  26.579  13.996  1.000 8.896  0 163 GLY A C   1 ? 
ATOM   1260 O  O   . GLY A 1 163 ? 27.029  25.744  13.608  1.000 10.462 0 163 GLY A O   1 ? 
ATOM   1261 N  N   . ASN A 1 164 ? 27.793  27.879  13.677  1.000 9.733  0 164 ASN A N   1 ? 
ATOM   1262 C  CA  . ASN A 1 164 ? 26.692  28.430  12.928  1.000 9.746  0 164 ASN A CA  1 ? 
ATOM   1263 C  C   . ASN A 1 164 ? 27.164  29.172  11.672  1.000 8.677  0 164 ASN A C   1 ? 
ATOM   1264 O  O   . ASN A 1 164 ? 26.428  29.948  11.106  1.000 9.045  0 164 ASN A O   1 ? 
ATOM   1265 C  CB  . ASN A 1 164 ? 25.809  29.327  13.797  1.000 9.541  0 164 ASN A CB  1 ? 
ATOM   1266 C  CG  . ASN A 1 164 ? 26.455  30.612  14.223  1.000 9.904  0 164 ASN A CG  1 ? 
ATOM   1267 O  OD1 . ASN A 1 164 ? 27.661  30.805  14.105  1.000 11.708 0 164 ASN A OD1 1 ? 
ATOM   1268 N  ND2 . ASN A 1 164 ? 25.674  31.565  14.699  1.000 11.664 0 164 ASN A ND2 1 ? 
ATOM   1269 N  N   . TYR A 1 165 ? 28.361  28.910  11.181  1.000 9.028  0 165 TYR A N   1 ? 
ATOM   1270 C  CA  . TYR A 1 165 ? 28.872  29.509  9.962   1.000 10.018 0 165 TYR A CA  1 ? 
ATOM   1271 C  C   . TYR A 1 165 ? 27.850  29.420  8.837   1.000 9.882  0 165 TYR A C   1 ? 
ATOM   1272 O  O   . TYR A 1 165 ? 27.288  28.360  8.590   1.000 10.304 0 165 TYR A O   1 ? 
ATOM   1273 C  CB  . TYR A 1 165 ? 30.173  28.845  9.520   1.000 11.563 0 165 TYR A CB  1 ? 
ATOM   1274 C  CG  . TYR A 1 165 ? 30.979  29.651  8.519   1.000 11.788 0 165 TYR A CG  1 ? 
ATOM   1275 C  CD1 . TYR A 1 165 ? 30.699  29.563  7.177   1.000 12.778 0 165 TYR A CD1 1 ? 
ATOM   1276 C  CD2 . TYR A 1 165 ? 31.999  30.495  8.927   1.000 12.993 0 165 TYR A CD2 1 ? 
ATOM   1277 C  CE1 . TYR A 1 165 ? 31.410  30.319  6.261   1.000 12.924 0 165 TYR A CE1 1 ? 
ATOM   1278 C  CE2 . TYR A 1 165 ? 32.771  31.207  8.014   1.000 12.085 0 165 TYR A CE2 1 ? 
ATOM   1279 C  CZ  . TYR A 1 165 ? 32.468  31.106  6.671   1.000 14.033 0 165 TYR A CZ  1 ? 
ATOM   1280 O  OH  . TYR A 1 165 ? 33.190  31.867  5.788   1.000 15.591 0 165 TYR A OH  1 ? 
ATOM   1281 N  N   . LEU A 1 166 ? 27.603  30.551  8.185   1.000 9.851  0 166 LEU A N   1 ? 
ATOM   1282 C  CA  . LEU A 1 166 ? 26.656  30.666  7.088   1.000 10.966 0 166 LEU A CA  1 ? 
ATOM   1283 C  C   . LEU A 1 166 ? 27.379  30.993  5.786   1.000 11.882 0 166 LEU A C   1 ? 
ATOM   1284 O  O   . LEU A 1 166 ? 27.734  32.138  5.520   1.000 12.693 0 166 LEU A O   1 ? 
ATOM   1285 C  CB  . LEU A 1 166 ? 25.552  31.708  7.351   1.000 10.749 0 166 LEU A CB  1 ? 
ATOM   1286 C  CG  . LEU A 1 166 ? 24.525  31.829  6.231   1.000 12.676 0 166 LEU A CG  1 ? 
ATOM   1287 C  CD1 . LEU A 1 166 ? 23.742  30.575  6.109   1.000 14.266 0 166 LEU A CD1 1 ? 
ATOM   1288 C  CD2 . LEU A 1 166 ? 23.605  32.984  6.519   1.000 14.410 0 166 LEU A CD2 1 ? 
ATOM   1289 N  N   . ASP A 1 167 ? 27.572  29.946  4.984   1.000 11.001 0 167 ASP A N   1 ? 
ATOM   1290 C  CA  . ASP A 1 167 ? 28.161  30.004  3.641   1.000 11.550 0 167 ASP A CA  1 ? 
ATOM   1291 C  C   . ASP A 1 167 ? 26.974  30.044  2.666   1.000 11.047 0 167 ASP A C   1 ? 
ATOM   1292 O  O   . ASP A 1 167 ? 26.390  29.001  2.316   1.000 11.251 0 167 ASP A O   1 ? 
ATOM   1293 C  CB  . ASP A 1 167 ? 29.023  28.753  3.465   1.000 11.848 0 167 ASP A CB  1 ? 
ATOM   1294 C  CG  . ASP A 1 167 ? 29.738  28.543  2.128   1.000 11.606 0 167 ASP A CG  1 ? 
ATOM   1295 O  OD1 . ASP A 1 167 ? 29.362  29.225  1.185   1.000 13.011 0 167 ASP A OD1 1 ? 
ATOM   1296 O  OD2 . ASP A 1 167 ? 30.689  27.759  2.145   1.000 13.610 0 167 ASP A OD2 1 ? 
ATOM   1297 N  N   . ASP A 1 168 ? 26.442  31.226  2.414   1.000 11.715 0 168 ASP A N   1 ? 
ATOM   1298 C  CA  . ASP A 1 168 ? 25.197  31.327  1.673   1.000 11.904 0 168 ASP A CA  1 ? 
ATOM   1299 C  C   . ASP A 1 168 ? 25.297  30.730  0.263   1.000 11.307 0 168 ASP A C   1 ? 
ATOM   1300 O  O   . ASP A 1 168 ? 24.277  30.221  -0.222  1.000 10.761 0 168 ASP A O   1 ? 
ATOM   1301 C  CB  . ASP A 1 168 ? 24.664  32.742  1.701   1.000 14.341 0 168 ASP A CB  1 ? 
ATOM   1302 C  CG  . ASP A 1 168 ? 25.643  33.743  1.166   1.000 16.828 0 168 ASP A CG  1 ? 
ATOM   1303 O  OD1 . ASP A 1 168 ? 26.717  33.882  1.803   1.000 20.036 0 168 ASP A OD1 1 ? 
ATOM   1304 O  OD2 . ASP A 1 168 ? 25.272  34.390  0.162   1.000 22.451 0 168 ASP A OD2 1 ? 
ATOM   1305 N  N   . ALA A 1 169 ? 26.447  30.827  -0.413  1.000 11.947 0 169 ALA A N   1 ? 
ATOM   1306 C  CA  . ALA A 1 169 ? 26.564  30.187  -1.731  1.000 12.167 0 169 ALA A CA  1 ? 
ATOM   1307 C  C   . ALA A 1 169 ? 26.397  28.680  -1.601  1.000 11.292 0 169 ALA A C   1 ? 
ATOM   1308 O  O   . ALA A 1 169 ? 25.825  28.034  -2.491  1.000 11.597 0 169 ALA A O   1 ? 
ATOM   1309 C  CB  . ALA A 1 169 ? 27.893  30.507  -2.405  1.000 12.986 0 169 ALA A CB  1 ? 
ATOM   1310 N  N   . LEU A 1 170 ? 26.938  28.086  -0.542  1.000 10.604 0 170 LEU A N   1 ? 
ATOM   1311 C  CA  . LEU A 1 170 ? 26.832  26.633  -0.371  1.000 9.994  0 170 LEU A CA  1 ? 
ATOM   1312 C  C   . LEU A 1 170 ? 25.395  26.265  -0.008  1.000 10.066 0 170 LEU A C   1 ? 
ATOM   1313 O  O   . LEU A 1 170 ? 24.877  25.254  -0.447  1.000 9.971  0 170 LEU A O   1 ? 
ATOM   1314 C  CB  . LEU A 1 170 ? 27.789  26.134  0.697   1.000 10.460 0 170 LEU A CB  1 ? 
ATOM   1315 C  CG  . LEU A 1 170 ? 27.799  24.633  0.924   1.000 11.297 0 170 LEU A CG  1 ? 
ATOM   1316 C  CD1 . LEU A 1 170 ? 28.263  23.904  -0.344  1.000 12.788 0 170 LEU A CD1 1 ? 
ATOM   1317 C  CD2 . LEU A 1 170 ? 28.711  24.282  2.107   1.000 11.550 0 170 LEU A CD2 1 ? 
ATOM   1318 N  N   . VAL A 1 171 ? 24.690  27.108  0.763   1.000 10.101 0 171 VAL A N   1 ? 
ATOM   1319 C  CA  . VAL A 1 171 ? 23.264  26.925  0.976   1.000 10.153 0 171 VAL A CA  1 ? 
ATOM   1320 C  C   . VAL A 1 171 ? 22.508  26.840  -0.350  1.000 9.905  0 171 VAL A C   1 ? 
ATOM   1321 O  O   . VAL A 1 171 ? 21.705  25.936  -0.600  1.000 9.931  0 171 VAL A O   1 ? 
ATOM   1322 C  CB  . VAL A 1 171 ? 22.655  28.041  1.841   1.000 9.946  0 171 VAL A CB  1 ? 
ATOM   1323 C  CG1 . VAL A 1 171 ? 21.148  27.980  1.871   1.000 10.335 0 171 VAL A CG1 1 ? 
ATOM   1324 C  CG2 . VAL A 1 171 ? 23.200  27.947  3.264   1.000 10.631 0 171 VAL A CG2 1 ? 
ATOM   1325 N  N   . ARG A 1 172 ? 22.761  27.812  -1.230  1.000 10.684 0 172 ARG A N   1 ? 
ATOM   1326 C  CA  . ARG A 1 172 ? 22.088  27.844  -2.527  1.000 10.863 0 172 ARG A CA  1 ? 
ATOM   1327 C  C   . ARG A 1 172 ? 22.436  26.624  -3.373  1.000 9.899  0 172 ARG A C   1 ? 
ATOM   1328 O  O   . ARG A 1 172 ? 21.521  26.027  -3.955  1.000 11.018 0 172 ARG A O   1 ? 
ATOM   1329 C  CB  . ARG A 1 172 ? 22.444  29.131  -3.305  1.000 12.024 0 172 ARG A CB  1 ? 
ATOM   1330 C  CG  . ARG A 1 172 ? 21.837  30.368  -2.655  1.000 13.046 0 172 ARG A CG  1 ? 
ATOM   1331 C  CD  . ARG A 1 172 ? 21.950  31.640  -3.529  1.000 12.575 0 172 ARG A CD  1 ? 
ATOM   1332 N  NE  . ARG A 1 172 ? 23.334  32.050  -3.661  1.000 14.979 0 172 ARG A NE  1 ? 
ATOM   1333 C  CZ  . ARG A 1 172 ? 23.982  32.795  -2.781  1.000 17.007 0 172 ARG A CZ  1 ? 
ATOM   1334 N  NH1 . ARG A 1 172 ? 23.357  33.171  -1.667  1.000 17.302 0 172 ARG A NH1 1 ? 
ATOM   1335 N  NH2 . ARG A 1 172 ? 25.240  33.156  -2.986  1.000 19.673 0 172 ARG A NH2 1 ? 
ATOM   1336 N  N   . GLN A 1 173 ? 23.689  26.233  -3.376  1.000 10.299 0 173 GLN A N   1 ? 
ATOM   1337 C  CA  . GLN A 1 173 ? 24.073  25.064  -4.162  1.000 10.891 0 173 GLN A CA  1 ? 
ATOM   1338 C  C   . GLN A 1 173 ? 23.463  23.777  -3.588  1.000 11.184 0 173 GLN A C   1 ? 
ATOM   1339 O  O   . GLN A 1 173 ? 22.977  22.914  -4.335  1.000 11.072 0 173 GLN A O   1 ? 
ATOM   1340 C  CB  . GLN A 1 173 ? 25.585  24.967  -4.283  1.000 12.653 0 173 GLN A CB  1 ? 
ATOM   1341 C  CG  . GLN A 1 173 ? 25.999  23.822  -5.197  1.000 15.794 0 173 GLN A CG  1 ? 
ATOM   1342 C  CD  . GLN A 1 173 ? 27.480  23.633  -5.224  1.000 21.234 0 173 GLN A CD  1 ? 
ATOM   1343 O  OE1 . GLN A 1 173 ? 28.178  23.808  -4.210  1.000 24.699 0 173 GLN A OE1 1 ? 
ATOM   1344 N  NE2 . GLN A 1 173 ? 27.991  23.383  -6.418  1.000 24.012 0 173 GLN A NE2 1 ? 
ATOM   1345 N  N   . ASP A 1 174 ? 23.459  23.622  -2.254  1.000 11.077 0 174 ASP A N   1 ? 
ATOM   1346 C  CA  . ASP A 1 174 ? 22.807  22.496  -1.601  1.000 9.458  0 174 ASP A CA  1 ? 
ATOM   1347 C  C   . ASP A 1 174 ? 21.341  22.393  -1.988  1.000 10.200 0 174 ASP A C   1 ? 
ATOM   1348 O  O   . ASP A 1 174 ? 20.820  21.316  -2.301  1.000 10.417 0 174 ASP A O   1 ? 
ATOM   1349 C  CB  . ASP A 1 174 ? 23.010  22.570  -0.105  1.000 9.987  0 174 ASP A CB  1 ? 
ATOM   1350 C  CG  . ASP A 1 174 ? 24.358  22.120  0.414   1.000 11.370 0 174 ASP A CG  1 ? 
ATOM   1351 O  OD1 . ASP A 1 174 ? 25.145  21.511  -0.332  1.000 10.852 0 174 ASP A OD1 1 ? 
ATOM   1352 O  OD2 . ASP A 1 174 ? 24.594  22.364  1.621   1.000 10.500 0 174 ASP A OD2 1 ? 
ATOM   1353 N  N   . ALA A 1 175 ? 20.600  23.501  -1.901  1.000 9.556  0 175 ALA A N   1 ? 
ATOM   1354 C  CA  . ALA A 1 175 ? 19.185  23.449  -2.213  1.000 10.514 0 175 ALA A CA  1 ? 
ATOM   1355 C  C   . ALA A 1 175 ? 18.955  23.038  -3.669  1.000 11.439 0 175 ALA A C   1 ? 
ATOM   1356 O  O   . ALA A 1 175 ? 18.078  22.229  -3.967  1.000 10.840 0 175 ALA A O   1 ? 
ATOM   1357 C  CB  . ALA A 1 175 ? 18.506  24.783  -1.902  1.000 10.702 0 175 ALA A CB  1 ? 
ATOM   1358 N  N   . GLN A 1 176 ? 19.742  23.657  -4.553  1.000 11.209 0 176 GLN A N   1 ? 
ATOM   1359 C  CA  . GLN A 1 176 ? 19.654  23.350  -5.983  1.000 12.089 0 176 GLN A CA  1 ? 
ATOM   1360 C  C   . GLN A 1 176 ? 19.997  21.876  -6.231  1.000 11.166 0 176 GLN A C   1 ? 
ATOM   1361 O  O   . GLN A 1 176 ? 19.315  21.182  -7.012  1.000 11.429 0 176 GLN A O   1 ? 
ATOM   1362 C  CB  . GLN A 1 176 ? 20.499  24.301  -6.815  1.000 13.987 0 176 GLN A CB  1 ? 
ATOM   1363 C  CG  . GLN A 1 176 ? 20.364  24.078  -8.319  1.000 17.448 0 176 GLN A CG  1 ? 
ATOM   1364 C  CD  . GLN A 1 176 ? 18.998  24.430  -8.882  1.000 19.460 0 176 GLN A CD  1 ? 
ATOM   1365 O  OE1 . GLN A 1 176 ? 18.227  25.225  -8.349  1.000 21.941 0 176 GLN A OE1 1 ? 
ATOM   1366 N  NE2 . GLN A 1 176 ? 18.672  23.846  -10.030 1.000 21.466 0 176 GLN A NE2 1 ? 
ATOM   1367 N  N   . ASP A 1 177 ? 21.041  21.379  -5.553  1.000 9.883  0 177 ASP A N   1 ? 
ATOM   1368 C  CA  . ASP A 1 177 ? 21.404  19.977  -5.656  1.000 11.960 0 177 ASP A CA  1 ? 
ATOM   1369 C  C   . ASP A 1 177 ? 20.255  19.081  -5.210  1.000 10.695 0 177 ASP A C   1 ? 
ATOM   1370 O  O   . ASP A 1 177 ? 20.005  18.018  -5.831  1.000 12.034 0 177 ASP A O   1 ? 
ATOM   1371 C  CB  . ASP A 1 177 ? 22.672  19.666  -4.891  1.000 12.800 0 177 ASP A CB  1 ? 
ATOM   1372 C  CG  . ASP A 1 177 ? 23.985  20.151  -5.485  1.000 13.455 0 177 ASP A CG  1 ? 
ATOM   1373 O  OD1 . ASP A 1 177 ? 23.988  20.609  -6.652  1.000 14.902 0 177 ASP A OD1 1 ? 
ATOM   1374 O  OD2 . ASP A 1 177 ? 24.976  20.121  -4.723  1.000 14.384 0 177 ASP A OD2 1 ? 
ATOM   1375 N  N   . LEU A 1 178 ? 19.584  19.414  -4.111  1.000 11.623 0 178 LEU A N   1 ? 
ATOM   1376 C  CA  . LEU A 1 178 ? 18.506  18.574  -3.616  1.000 10.767 0 178 LEU A CA  1 ? 
ATOM   1377 C  C   . LEU A 1 178 ? 17.355  18.619  -4.596  1.000 11.526 0 178 LEU A C   1 ? 
ATOM   1378 O  O   . LEU A 1 178 ? 16.691  17.601  -4.806  1.000 12.241 0 178 LEU A O   1 ? 
ATOM   1379 C  CB  . LEU A 1 178 ? 18.054  18.972  -2.210  1.000 10.947 0 178 LEU A CB  1 ? 
ATOM   1380 C  CG  . LEU A 1 178 ? 19.078  18.784  -1.084  1.000 12.644 0 178 LEU A CG  1 ? 
ATOM   1381 C  CD1 . LEU A 1 178 ? 18.520  19.325  0.227   1.000 14.872 0 178 LEU A CD1 1 ? 
ATOM   1382 C  CD2 . LEU A 1 178 ? 19.457  17.336  -0.925  1.000 13.960 0 178 LEU A CD2 1 ? 
ATOM   1383 N  N   . TYR A 1 179 ? 17.076  19.794  -5.180  1.000 11.464 0 179 TYR A N   1 ? 
ATOM   1384 C  CA  . TYR A 1 179 ? 15.990  19.897  -6.148  1.000 13.213 0 179 TYR A CA  1 ? 
ATOM   1385 C  C   . TYR A 1 179 ? 16.281  18.999  -7.353  1.000 13.767 0 179 TYR A C   1 ? 
ATOM   1386 O  O   . TYR A 1 179 ? 15.429  18.194  -7.766  1.000 13.715 0 179 TYR A O   1 ? 
ATOM   1387 C  CB  . TYR A 1 179 ? 15.850  21.374  -6.526  1.000 15.132 0 179 TYR A CB  1 ? 
ATOM   1388 C  CG  . TYR A 1 179 ? 14.735  21.665  -7.512  1.000 18.272 0 179 TYR A CG  1 ? 
ATOM   1389 C  CD1 . TYR A 1 179 ? 13.423  21.435  -7.166  1.000 20.272 0 179 TYR A CD1 1 ? 
ATOM   1390 C  CD2 . TYR A 1 179 ? 15.030  22.042  -8.812  1.000 25.167 0 179 TYR A CD2 1 ? 
ATOM   1391 C  CE1 . TYR A 1 179 ? 12.400  21.654  -8.072  1.000 23.482 0 179 TYR A CE1 1 ? 
ATOM   1392 C  CE2 . TYR A 1 179 ? 14.012  22.276  -9.731  1.000 30.044 0 179 TYR A CE2 1 ? 
ATOM   1393 C  CZ  . TYR A 1 179 ? 12.700  22.119  -9.333  1.000 27.673 0 179 TYR A CZ  1 ? 
ATOM   1394 O  OH  . TYR A 1 179 ? 11.657  22.314  -10.205 1.000 37.192 0 179 TYR A OH  1 ? 
ATOM   1395 N  N   . GLU A 1 180 ? 17.481  19.163  -7.922  1.000 12.472 0 180 GLU A N   1 ? 
ATOM   1396 C  CA  . GLU A 1 180 ? 17.860  18.393  -9.098  1.000 14.781 0 180 GLU A CA  1 ? 
ATOM   1397 C  C   . GLU A 1 180 ? 17.927  16.909  -8.772  1.000 13.759 0 180 GLU A C   1 ? 
ATOM   1398 O  O   . GLU A 1 180 ? 17.587  16.082  -9.626  1.000 15.373 0 180 GLU A O   1 ? 
ATOM   1399 C  CB  . GLU A 1 180 ? 19.179  18.895  -9.668  1.000 15.942 0 180 GLU A CB  1 ? 
ATOM   1400 C  CG  . GLU A 1 180 ? 19.075  20.291  -10.274 1.000 19.326 0 180 GLU A CG  1 ? 
ATOM   1401 C  CD  . GLU A 1 180 ? 20.396  20.816  -10.805 1.000 25.080 0 180 GLU A CD  1 ? 
ATOM   1402 O  OE1 . GLU A 1 180 ? 21.353  20.006  -10.881 1.000 30.570 0 180 GLU A OE1 1 ? 
ATOM   1403 O  OE2 . GLU A 1 180 ? 20.464  22.023  -11.136 1.000 25.612 0 180 GLU A OE2 1 ? 
ATOM   1404 N  N   . ALA A 1 181 ? 18.263  16.521  -7.540  1.000 13.342 0 181 ALA A N   1 ? 
ATOM   1405 C  CA  . ALA A 1 181 ? 18.290  15.115  -7.145  1.000 12.353 0 181 ALA A CA  1 ? 
ATOM   1406 C  C   . ALA A 1 181 ? 16.924  14.444  -7.238  1.000 13.072 0 181 ALA A C   1 ? 
ATOM   1407 O  O   . ALA A 1 181 ? 16.841  13.235  -7.496  1.000 14.688 0 181 ALA A O   1 ? 
ATOM   1408 C  CB  . ALA A 1 181 ? 18.826  15.047  -5.738  1.000 12.043 0 181 ALA A CB  1 ? 
ATOM   1409 N  N   . GLY A 1 182 ? 15.854  15.233  -7.076  1.000 15.118 0 182 GLY A N   1 ? 
ATOM   1410 C  CA  . GLY A 1 182 ? 14.500  14.755  -7.183  1.000 16.470 0 182 GLY A CA  1 ? 
ATOM   1411 C  C   . GLY A 1 182 ? 14.002  14.720  -8.626  1.000 19.268 0 182 GLY A C   1 ? 
ATOM   1412 O  O   . GLY A 1 182 ? 13.012  14.041  -8.868  1.000 26.349 0 182 GLY A O   1 ? 
ATOM   1413 N  N   . GLU A 1 183 ? 14.586  15.528  -9.523  1.000 18.832 0 183 GLU A N   1 ? 
ATOM   1414 C  CA  . GLU A 1 183 ? 14.117  15.678  -10.897 1.000 20.870 0 183 GLU A CA  1 ? 
ATOM   1415 C  C   . GLU A 1 183 ? 14.828  14.706  -11.843 1.000 21.318 0 183 GLU A C   1 ? 
ATOM   1416 O  O   . GLU A 1 183 ? 14.609  14.760  -13.053 1.000 23.939 0 183 GLU A O   1 ? 
ATOM   1417 C  CB  . GLU A 1 183 ? 14.407  17.096  -11.367 1.000 23.145 0 183 GLU A CB  1 ? 
ATOM   1418 C  CG  . GLU A 1 183 ? 13.533  18.175  -10.734 1.000 25.795 0 183 GLU A CG  1 ? 
ATOM   1419 C  CD  . GLU A 1 183 ? 14.003  19.497  -11.289 1.000 33.618 0 183 GLU A CD  1 ? 
ATOM   1420 O  OE1 . GLU A 1 183 ? 15.247  19.735  -11.351 1.000 39.973 0 183 GLU A OE1 1 ? 
ATOM   1421 O  OE2 . GLU A 1 183 ? 13.124  20.272  -11.706 1.000 39.962 0 183 GLU A OE2 1 ? 
ATOM   1422 N  N   . LYS A 1 184 ? 15.694  13.834  -11.314 1.000 20.564 0 184 LYS A N   1 ? 
ATOM   1423 C  CA  . LYS A 1 184 ? 16.420  12.895  -12.155 1.000 21.936 0 184 LYS A CA  1 ? 
ATOM   1424 C  C   . LYS A 1 184 ? 15.382  11.959  -12.754 1.000 22.291 0 184 LYS A C   1 ? 
ATOM   1425 O  O   . LYS A 1 184 ? 14.384  11.642  -12.125 1.000 23.381 0 184 LYS A O   1 ? 
ATOM   1426 C  CB  . LYS A 1 184 ? 17.500  12.132  -11.382 1.000 25.480 0 184 LYS A CB  1 ? 
ATOM   1427 C  CG  . LYS A 1 184 ? 18.737  12.953  -11.075 1.000 31.687 0 184 LYS A CG  1 ? 
ATOM   1428 C  CD  . LYS A 1 184 ? 19.896  12.151  -10.497 1.000 41.011 0 184 LYS A CD  1 ? 
ATOM   1429 C  CE  . LYS A 1 184 ? 20.594  11.281  -11.504 1.000 47.090 0 184 LYS A CE  1 ? 
ATOM   1430 N  NZ  . LYS A 1 184 ? 21.354  12.095  -12.459 1.000 49.894 0 184 LYS A NZ  1 ? 
ATOM   1431 N  N   . LYS A 1 185 ? 15.634  11.453  -13.952 1.000 19.325 0 185 LYS A N   1 ? 
ATOM   1432 C  CA  . LYS A 1 185 ? 14.627  10.683  -14.653 1.000 18.014 0 185 LYS A CA  1 ? 
ATOM   1433 C  C   . LYS A 1 185 ? 14.377  9.311   -14.019 1.000 18.894 0 185 LYS A C   1 ? 
ATOM   1434 O  O   . LYS A 1 185 ? 13.223  8.893   -13.986 1.000 21.188 0 185 LYS A O   1 ? 
ATOM   1435 C  CB  . LYS A 1 185 ? 15.014  10.609  -16.145 1.000 18.693 0 185 LYS A CB  1 ? 
ATOM   1436 C  CG  . LYS A 1 185 ? 13.976  9.974   -17.052 1.000 19.882 0 185 LYS A CG  1 ? 
ATOM   1437 C  CD  . LYS A 1 185 ? 14.336  10.017  -18.531 1.000 20.108 0 185 LYS A CD  1 ? 
ATOM   1438 C  CE  . LYS A 1 185 ? 13.271  9.424   -19.388 1.000 22.417 0 185 LYS A CE  1 ? 
ATOM   1439 N  NZ  . LYS A 1 185 ? 12.123  10.344  -19.420 1.000 26.757 0 185 LYS A NZ  1 ? 
ATOM   1440 N  N   . TRP A 1 186 ? 15.435  8.578   -13.661 1.000 18.036 0 186 TRP A N   1 ? 
ATOM   1441 C  CA  . TRP A 1 186 ? 15.380  7.173   -13.288 1.000 17.486 0 186 TRP A CA  1 ? 
ATOM   1442 C  C   . TRP A 1 186 ? 15.801  6.926   -11.845 1.000 22.126 0 186 TRP A C   1 ? 
ATOM   1443 O  O   . TRP A 1 186 ? 16.450  5.907   -11.556 1.000 25.683 0 186 TRP A O   1 ? 
ATOM   1444 C  CB  . TRP A 1 186 ? 16.266  6.313   -14.202 1.000 15.910 0 186 TRP A CB  1 ? 
ATOM   1445 C  CG  . TRP A 1 186 ? 15.778  6.334   -15.632 1.000 13.685 0 186 TRP A CG  1 ? 
ATOM   1446 C  CD1 . TRP A 1 186 ? 16.384  6.879   -16.718 1.000 14.348 0 186 TRP A CD1 1 ? 
ATOM   1447 C  CD2 . TRP A 1 186 ? 14.510  5.811   -16.076 1.000 15.277 0 186 TRP A CD2 1 ? 
ATOM   1448 N  NE1 . TRP A 1 186 ? 15.564  6.741   -17.812 1.000 12.056 0 186 TRP A NE1 1 ? 
ATOM   1449 C  CE2 . TRP A 1 186 ? 14.426  6.076   -17.466 1.000 14.669 0 186 TRP A CE2 1 ? 
ATOM   1450 C  CE3 . TRP A 1 186 ? 13.475  5.120   -15.454 1.000 17.524 0 186 TRP A CE3 1 ? 
ATOM   1451 C  CZ2 . TRP A 1 186 ? 13.302  5.710   -18.212 1.000 14.969 0 186 TRP A CZ2 1 ? 
ATOM   1452 C  CZ3 . TRP A 1 186 ? 12.373  4.727   -16.190 1.000 17.939 0 186 TRP A CZ3 1 ? 
ATOM   1453 C  CH2 . TRP A 1 186 ? 12.293  5.024   -17.555 1.000 16.914 0 186 TRP A CH2 1 ? 
ATOM   1454 N  N   . GLY A 1 187 ? 15.302  7.770   -10.946 1.000 21.084 0 187 GLY A N   1 ? 
ATOM   1455 C  CA  . GLY A 1 187 ? 15.529  7.541   -9.528  1.000 18.659 0 187 GLY A CA  1 ? 
ATOM   1456 C  C   . GLY A 1 187 ? 16.249  8.725   -8.892  1.000 16.715 0 187 GLY A C   1 ? 
ATOM   1457 O  O   . GLY A 1 187 ? 17.213  9.315   -9.407  1.000 17.451 0 187 GLY A O   1 ? 
ATOM   1458 N  N   . THR A 1 188 ? 15.822  8.979   -7.659  1.000 14.664 0 188 THR A N   1 ? 
ATOM   1459 C  CA  . THR A 1 188 ? 16.381  10.065  -6.890  1.000 13.976 0 188 THR A CA  1 ? 
ATOM   1460 C  C   . THR A 1 188 ? 17.873  9.876   -6.666  1.000 11.832 0 188 THR A C   1 ? 
ATOM   1461 O  O   . THR A 1 188 ? 18.299  8.734   -6.418  1.000 13.440 0 188 THR A O   1 ? 
ATOM   1462 C  CB  . THR A 1 188 ? 15.663  10.044  -5.557  1.000 13.374 0 188 THR A CB  1 ? 
ATOM   1463 O  OG1 . THR A 1 188 ? 14.282  10.247  -5.803  1.000 15.640 0 188 THR A OG1 1 ? 
ATOM   1464 C  CG2 . THR A 1 188 ? 16.136  11.145  -4.625  1.000 14.334 0 188 THR A CG2 1 ? 
ATOM   1465 N  N   . ASP A 1 189 ? 18.670  10.970  -6.706  1.000 11.899 0 189 ASP A N   1 ? 
ATOM   1466 C  CA  . ASP A 1 189 ? 20.056  10.901  -6.245  1.000 12.799 0 189 ASP A CA  1 ? 
ATOM   1467 C  C   . ASP A 1 189 ? 20.032  11.021  -4.723  1.000 12.551 0 189 ASP A C   1 ? 
ATOM   1468 O  O   . ASP A 1 189 ? 20.079  12.117  -4.138  1.000 13.233 0 189 ASP A O   1 ? 
ATOM   1469 C  CB  . ASP A 1 189 ? 20.933  11.986  -6.840  1.000 14.746 0 189 ASP A CB  1 ? 
ATOM   1470 C  CG  . ASP A 1 189 ? 22.392  11.917  -6.395  1.000 15.801 0 189 ASP A CG  1 ? 
ATOM   1471 O  OD1 . ASP A 1 189 ? 22.696  11.077  -5.535  1.000 18.563 0 189 ASP A OD1 1 ? 
ATOM   1472 O  OD2 . ASP A 1 189 ? 23.153  12.716  -6.946  1.000 19.916 0 189 ASP A OD2 1 ? 
ATOM   1473 N  N   . GLU A 1 190 ? 19.986  9.875   -4.067  1.000 11.054 0 190 GLU A N   1 ? 
ATOM   1474 C  CA  . GLU A 1 190 ? 19.822  9.850   -2.635  1.000 11.602 0 190 GLU A CA  1 ? 
ATOM   1475 C  C   . GLU A 1 190 ? 21.082  10.278  -1.908  1.000 10.782 0 190 GLU A C   1 ? 
ATOM   1476 O  O   . GLU A 1 190 ? 21.000  10.681  -0.735  1.000 11.402 0 190 GLU A O   1 ? 
ATOM   1477 C  CB  . GLU A 1 190 ? 19.339  8.460   -2.210  1.000 13.096 0 190 GLU A CB  1 ? 
ATOM   1478 C  CG  . GLU A 1 190 ? 17.925  8.147   -2.691  1.000 14.139 0 190 GLU A CG  1 ? 
ATOM   1479 C  CD  . GLU A 1 190 ? 17.328  6.867   -2.169  1.000 15.824 0 190 GLU A CD  1 ? 
ATOM   1480 O  OE1 . GLU A 1 190 ? 18.072  5.954   -1.803  1.000 17.388 0 190 GLU A OE1 1 ? 
ATOM   1481 O  OE2 . GLU A 1 190 ? 16.089  6.888   -2.068  1.000 18.321 0 190 GLU A OE2 1 ? 
ATOM   1482 N  N   . VAL A 1 191 ? 22.248  10.161  -2.531  1.000 10.897 0 191 VAL A N   1 ? 
ATOM   1483 C  CA  . VAL A 1 191 ? 23.482  10.578  -1.883  1.000 10.652 0 191 VAL A CA  1 ? 
ATOM   1484 C  C   . VAL A 1 191 ? 23.434  12.074  -1.576  1.000 10.938 0 191 VAL A C   1 ? 
ATOM   1485 O  O   . VAL A 1 191 ? 23.988  12.484  -0.560  1.000 11.070 0 191 VAL A O   1 ? 
ATOM   1486 C  CB  . VAL A 1 191 ? 24.687  10.206  -2.755  1.000 12.250 0 191 VAL A CB  1 ? 
ATOM   1487 C  CG1 . VAL A 1 191 ? 25.984  10.818  -2.234  1.000 12.625 0 191 VAL A CG1 1 ? 
ATOM   1488 C  CG2 . VAL A 1 191 ? 24.736  8.689   -2.907  1.000 14.994 0 191 VAL A CG2 1 ? 
ATOM   1489 N  N   . LYS A 1 192 ? 22.805  12.900  -2.429  1.000 10.267 0 192 LYS A N   1 ? 
ATOM   1490 C  CA  . LYS A 1 192 ? 22.739  14.335  -2.131  1.000 11.163 0 192 LYS A CA  1 ? 
ATOM   1491 C  C   . LYS A 1 192 ? 21.993  14.580  -0.820  1.000 10.419 0 192 LYS A C   1 ? 
ATOM   1492 O  O   . LYS A 1 192 ? 22.384  15.458  -0.038  1.000 10.877 0 192 LYS A O   1 ? 
ATOM   1493 C  CB  . LYS A 1 192 ? 22.066  15.142  -3.258  1.000 13.048 0 192 LYS A CB  1 ? 
ATOM   1494 C  CG  . LYS A 1 192 ? 22.775  15.211  -4.573  1.000 16.038 0 192 LYS A CG  1 ? 
ATOM   1495 C  CD  . LYS A 1 192 ? 24.147  15.839  -4.543  1.000 19.740 0 192 LYS A CD  1 ? 
ATOM   1496 C  CE  . LYS A 1 192 ? 24.727  15.853  -5.937  1.000 26.741 0 192 LYS A CE  1 ? 
ATOM   1497 N  NZ  . LYS A 1 192 ? 26.153  16.180  -5.820  1.000 35.184 0 192 LYS A NZ  1 ? 
ATOM   1498 N  N   . PHE A 1 193 ? 20.900  13.844  -0.590  1.000 10.047 0 193 PHE A N   1 ? 
ATOM   1499 C  CA  . PHE A 1 193 ? 20.134  13.981  0.636   1.000 10.974 0 193 PHE A CA  1 ? 
ATOM   1500 C  C   . PHE A 1 193 ? 20.952  13.527  1.839   1.000 10.863 0 193 PHE A C   1 ? 
ATOM   1501 O  O   . PHE A 1 193 ? 21.019  14.186  2.887   1.000 9.816  0 193 PHE A O   1 ? 
ATOM   1502 C  CB  . PHE A 1 193 ? 18.853  13.143  0.561   1.000 11.655 0 193 PHE A CB  1 ? 
ATOM   1503 C  CG  . PHE A 1 193 ? 17.774  13.872  -0.223  1.000 11.829 0 193 PHE A CG  1 ? 
ATOM   1504 C  CD1 . PHE A 1 193 ? 17.677  13.674  -1.604  1.000 14.281 0 193 PHE A CD1 1 ? 
ATOM   1505 C  CD2 . PHE A 1 193 ? 16.811  14.701  0.382   1.000 12.241 0 193 PHE A CD2 1 ? 
ATOM   1506 C  CE1 . PHE A 1 193 ? 16.728  14.353  -2.349  1.000 14.890 0 193 PHE A CE1 1 ? 
ATOM   1507 C  CE2 . PHE A 1 193 ? 15.866  15.385  -0.379  1.000 14.675 0 193 PHE A CE2 1 ? 
ATOM   1508 C  CZ  . PHE A 1 193 ? 15.809  15.162  -1.743  1.000 15.261 0 193 PHE A CZ  1 ? 
ATOM   1509 N  N   . LEU A 1 194 ? 21.646  12.409  1.711   1.000 10.255 0 194 LEU A N   1 ? 
ATOM   1510 C  CA  . LEU A 1 194 ? 22.543  11.906  2.742   1.000 10.263 0 194 LEU A CA  1 ? 
ATOM   1511 C  C   . LEU A 1 194 ? 23.586  12.973  3.075   1.000 10.273 0 194 LEU A C   1 ? 
ATOM   1512 O  O   . LEU A 1 194 ? 23.800  13.316  4.257   1.000 11.193 0 194 LEU A O   1 ? 
ATOM   1513 C  CB  . LEU A 1 194 ? 23.240  10.613  2.251   1.000 11.841 0 194 LEU A CB  1 ? 
ATOM   1514 C  CG  . LEU A 1 194 ? 24.400  10.142  3.140   1.000 12.167 0 194 LEU A CG  1 ? 
ATOM   1515 C  CD1 . LEU A 1 194 ? 23.991  9.567   4.481   1.000 13.065 0 194 LEU A CD1 1 ? 
ATOM   1516 C  CD2 . LEU A 1 194 ? 25.230  9.129   2.379   1.000 13.787 0 194 LEU A CD2 1 ? 
ATOM   1517 N  N   . THR A 1 195 ? 24.287  13.500  2.069   1.000 10.893 0 195 THR A N   1 ? 
ATOM   1518 C  CA  . THR A 1 195 ? 25.401  14.432  2.267   1.000 11.900 0 195 THR A CA  1 ? 
ATOM   1519 C  C   . THR A 1 195 ? 24.897  15.650  3.035   1.000 10.796 0 195 THR A C   1 ? 
ATOM   1520 O  O   . THR A 1 195 ? 25.496  16.115  4.011   1.000 10.897 0 195 THR A O   1 ? 
ATOM   1521 C  CB  . THR A 1 195 ? 26.007  14.948  0.941   1.000 14.986 0 195 THR A CB  1 ? 
ATOM   1522 O  OG1 . THR A 1 195 ? 26.614  13.821  0.333   1.000 19.797 0 195 THR A OG1 1 ? 
ATOM   1523 C  CG2 . THR A 1 195 ? 27.082  16.018  1.114   1.000 15.838 0 195 THR A CG2 1 ? 
ATOM   1524 N  N   . VAL A 1 196 ? 23.897  16.294  2.452   1.000 9.363  0 196 VAL A N   1 ? 
ATOM   1525 C  CA  . VAL A 1 196 ? 23.469  17.580  2.974   1.000 9.865  0 196 VAL A CA  1 ? 
ATOM   1526 C  C   . VAL A 1 196 ? 22.943  17.374  4.395   1.000 9.049  0 196 VAL A C   1 ? 
ATOM   1527 O  O   . VAL A 1 196 ? 23.354  18.087  5.306   1.000 8.744  0 196 VAL A O   1 ? 
ATOM   1528 C  CB  . VAL A 1 196 ? 22.436  18.262  2.068   1.000 10.190 0 196 VAL A CB  1 ? 
ATOM   1529 C  CG1 . VAL A 1 196 ? 21.824  19.493  2.748   1.000 11.264 0 196 VAL A CG1 1 ? 
ATOM   1530 C  CG2 . VAL A 1 196 ? 23.056  18.662  0.735   1.000 10.805 0 196 VAL A CG2 1 ? 
ATOM   1531 N  N   . LEU A 1 197 ? 22.043  16.398  4.593   1.000 8.292  0 197 LEU A N   1 ? 
ATOM   1532 C  CA  . LEU A 1 197 ? 21.356  16.253  5.871   1.000 8.439  0 197 LEU A CA  1 ? 
ATOM   1533 C  C   . LEU A 1 197 ? 22.207  15.650  6.985   1.000 9.035  0 197 LEU A C   1 ? 
ATOM   1534 O  O   . LEU A 1 197 ? 21.938  15.958  8.164   1.000 9.418  0 197 LEU A O   1 ? 
ATOM   1535 C  CB  . LEU A 1 197 ? 20.068  15.457  5.677   1.000 8.898  0 197 LEU A CB  1 ? 
ATOM   1536 C  CG  . LEU A 1 197 ? 18.970  16.227  4.913   1.000 10.255 0 197 LEU A CG  1 ? 
ATOM   1537 C  CD1 . LEU A 1 197 ? 17.807  15.324  4.595   1.000 11.146 0 197 LEU A CD1 1 ? 
ATOM   1538 C  CD2 . LEU A 1 197 ? 18.505  17.480  5.640   1.000 12.768 0 197 LEU A CD2 1 ? 
ATOM   1539 N  N   . CYS A 1 198 ? 23.262  14.938  6.642   1.000 8.972  0 198 CYS A N   1 ? 
ATOM   1540 C  CA  . CYS A 1 198 ? 24.150  14.354  7.651   1.000 8.754  0 198 CYS A CA  1 ? 
ATOM   1541 C  C   . CYS A 1 198 ? 25.403  15.185  7.884   1.000 8.780  0 198 CYS A C   1 ? 
ATOM   1542 O  O   . CYS A 1 198 ? 25.976  14.988  8.942   1.000 9.919  0 198 CYS A O   1 ? 
ATOM   1543 C  CB  . CYS A 1 198 ? 24.518  12.919  7.313   1.000 9.330  0 198 CYS A CB  1 ? 
ATOM   1544 S  SG  . CYS A 1 198 ? 23.144  11.761  7.502   1.000 11.626 0 198 CYS A SG  1 ? 
ATOM   1545 N  N   . SER A 1 199 ? 25.816  16.085  6.963   1.000 8.588  0 199 SER A N   1 ? 
ATOM   1546 C  CA  A SER A 1 199 ? 27.104  16.787  7.075   0.500 8.634  0 199 SER A CA  1 ? 
ATOM   1547 C  CA  B SER A 1 199 ? 27.105  16.761  7.147   0.500 9.283  0 199 SER A CA  1 ? 
ATOM   1548 C  C   . SER A 1 199 ? 27.012  18.232  7.589   1.000 8.374  0 199 SER A C   1 ? 
ATOM   1549 O  O   . SER A 1 199 ? 27.947  18.714  8.245   1.000 9.234  0 199 SER A O   1 ? 
ATOM   1550 C  CB  A SER A 1 199 ? 27.815  16.864  5.743   0.500 9.076  0 199 SER A CB  1 ? 
ATOM   1551 C  CB  B SER A 1 199 ? 27.985  16.634  5.914   0.500 10.998 0 199 SER A CB  1 ? 
ATOM   1552 O  OG  A SER A 1 199 ? 28.002  15.600  5.138   0.500 11.063 0 199 SER A OG  1 ? 
ATOM   1553 O  OG  B SER A 1 199 ? 27.611  17.520  4.872   0.500 15.182 0 199 SER A OG  1 ? 
ATOM   1554 N  N   . ARG A 1 200 ? 25.955  18.946  7.213   1.000 8.360  0 200 ARG A N   1 ? 
ATOM   1555 C  CA  . ARG A 1 200 ? 25.940  20.403  7.382   1.000 8.082  0 200 ARG A CA  1 ? 
ATOM   1556 C  C   . ARG A 1 200 ? 25.508  20.792  8.796   1.000 8.728  0 200 ARG A C   1 ? 
ATOM   1557 O  O   . ARG A 1 200 ? 24.809  20.073  9.496   1.000 9.057  0 200 ARG A O   1 ? 
ATOM   1558 C  CB  . ARG A 1 200 ? 25.009  21.039  6.360   1.000 8.649  0 200 ARG A CB  1 ? 
ATOM   1559 C  CG  . ARG A 1 200 ? 25.349  20.728  4.901   1.000 9.020  0 200 ARG A CG  1 ? 
ATOM   1560 C  CD  . ARG A 1 200 ? 26.639  21.328  4.392   1.000 9.479  0 200 ARG A CD  1 ? 
ATOM   1561 N  NE  . ARG A 1 200 ? 26.736  21.187  2.937   1.000 10.557 0 200 ARG A NE  1 ? 
ATOM   1562 C  CZ  . ARG A 1 200 ? 27.468  20.297  2.305   1.000 13.127 0 200 ARG A CZ  1 ? 
ATOM   1563 N  NH1 . ARG A 1 200 ? 28.371  19.515  2.888   1.000 15.330 0 200 ARG A NH1 1 ? 
ATOM   1564 N  NH2 . ARG A 1 200 ? 27.236  20.104  1.013   1.000 13.390 0 200 ARG A NH2 1 ? 
ATOM   1565 N  N   . ASN A 1 201 ? 25.933  21.992  9.222   1.000 7.717  0 201 ASN A N   1 ? 
ATOM   1566 C  CA  . ASN A 1 201 ? 25.546  22.505  10.524  1.000 7.807  0 201 ASN A CA  1 ? 
ATOM   1567 C  C   . ASN A 1 201 ? 24.069  22.887  10.551  1.000 7.849  0 201 ASN A C   1 ? 
ATOM   1568 O  O   . ASN A 1 201 ? 23.417  23.097  9.525   1.000 7.915  0 201 ASN A O   1 ? 
ATOM   1569 C  CB  . ASN A 1 201 ? 26.508  23.573  11.020  1.000 8.090  0 201 ASN A CB  1 ? 
ATOM   1570 C  CG  . ASN A 1 201 ? 26.296  24.955  10.458  1.000 8.413  0 201 ASN A CG  1 ? 
ATOM   1571 O  OD1 . ASN A 1 201 ? 25.201  25.496  10.541  1.000 8.702  0 201 ASN A OD1 1 ? 
ATOM   1572 N  ND2 . ASN A 1 201 ? 27.348  25.582  9.966   1.000 9.293  0 201 ASN A ND2 1 ? 
ATOM   1573 N  N   . ARG A 1 202 ? 23.517  22.973  11.773  1.000 8.014  0 202 ARG A N   1 ? 
ATOM   1574 C  CA  . ARG A 1 202 ? 22.080  23.241  11.922  1.000 8.210  0 202 ARG A CA  1 ? 
ATOM   1575 C  C   . ARG A 1 202 ? 21.651  24.545  11.235  1.000 8.169  0 202 ARG A C   1 ? 
ATOM   1576 O  O   . ARG A 1 202 ? 20.641  24.580  10.559  1.000 8.009  0 202 ARG A O   1 ? 
ATOM   1577 C  CB  . ARG A 1 202 ? 21.708  23.237  13.397  1.000 8.463  0 202 ARG A CB  1 ? 
ATOM   1578 C  CG  . ARG A 1 202 ? 20.238  23.511  13.621  1.000 8.753  0 202 ARG A CG  1 ? 
ATOM   1579 C  CD  . ARG A 1 202 ? 19.854  23.499  15.095  1.000 9.684  0 202 ARG A CD  1 ? 
ATOM   1580 N  NE  . ARG A 1 202 ? 18.410  23.699  15.213  1.000 10.421 0 202 ARG A NE  1 ? 
ATOM   1581 C  CZ  . ARG A 1 202 ? 17.738  24.168  16.272  1.000 10.432 0 202 ARG A CZ  1 ? 
ATOM   1582 N  NH1 . ARG A 1 202 ? 18.400  24.755  17.241  1.000 12.065 0 202 ARG A NH1 1 ? 
ATOM   1583 N  NH2 . ARG A 1 202 ? 16.428  24.111  16.238  1.000 11.681 0 202 ARG A NH2 1 ? 
ATOM   1584 N  N   . ASN A 1 203 ? 22.332  25.651  11.553  1.000 7.532  0 203 ASN A N   1 ? 
ATOM   1585 C  CA  . ASN A 1 203 ? 21.971  26.929  10.947  1.000 7.630  0 203 ASN A CA  1 ? 
ATOM   1586 C  C   . ASN A 1 203 ? 21.977  26.830  9.416   1.000 7.949  0 203 ASN A C   1 ? 
ATOM   1587 O  O   . ASN A 1 203 ? 21.097  27.353  8.739   1.000 8.163  0 203 ASN A O   1 ? 
ATOM   1588 C  CB  . ASN A 1 203 ? 22.955  28.001  11.399  1.000 7.642  0 203 ASN A CB  1 ? 
ATOM   1589 C  CG  . ASN A 1 203 ? 22.576  29.411  10.979  1.000 7.687  0 203 ASN A CG  1 ? 
ATOM   1590 O  OD1 . ASN A 1 203 ? 21.391  29.724  10.898  1.000 8.990  0 203 ASN A OD1 1 ? 
ATOM   1591 N  ND2 . ASN A 1 203 ? 23.543  30.235  10.641  1.000 8.518  0 203 ASN A ND2 1 ? 
ATOM   1592 N  N   . HIS A 1 204 ? 23.024  26.222  8.860   1.000 7.785  0 204 HIS A N   1 ? 
ATOM   1593 C  CA  . HIS A 1 204 ? 23.081  25.937  7.442   1.000 7.416  0 204 HIS A CA  1 ? 
ATOM   1594 C  C   . HIS A 1 204 ? 21.825  25.207  6.970   1.000 7.395  0 204 HIS A C   1 ? 
ATOM   1595 O  O   . HIS A 1 204 ? 21.215  25.623  5.963   1.000 8.843  0 204 HIS A O   1 ? 
ATOM   1596 C  CB  . HIS A 1 204 ? 24.346  25.152  7.153   1.000 7.944  0 204 HIS A CB  1 ? 
ATOM   1597 C  CG  . HIS A 1 204 ? 24.581  24.978  5.680   1.000 8.770  0 204 HIS A CG  1 ? 
ATOM   1598 N  ND1 . HIS A 1 204 ? 24.012  24.045  4.837   1.000 10.762 0 204 HIS A ND1 1 ? 
ATOM   1599 C  CD2 . HIS A 1 204 ? 25.447  25.706  4.949   1.000 7.515  0 204 HIS A CD2 1 ? 
ATOM   1600 C  CE1 . HIS A 1 204 ? 24.523  24.260  3.596   1.000 7.516  0 204 HIS A CE1 1 ? 
ATOM   1601 N  NE2 . HIS A 1 204 ? 25.398  25.267  3.664   1.000 11.494 0 204 HIS A NE2 1 ? 
ATOM   1602 N  N   . LEU A 1 205 ? 21.496  24.116  7.645   1.000 7.483  0 205 LEU A N   1 ? 
ATOM   1603 C  CA  . LEU A 1 205 ? 20.331  23.351  7.223   1.000 7.984  0 205 LEU A CA  1 ? 
ATOM   1604 C  C   . LEU A 1 205 ? 19.019  24.137  7.306   1.000 8.291  0 205 LEU A C   1 ? 
ATOM   1605 O  O   . LEU A 1 205 ? 18.195  24.038  6.394   1.000 9.292  0 205 LEU A O   1 ? 
ATOM   1606 C  CB  . LEU A 1 205 ? 20.257  22.037  7.999   1.000 8.681  0 205 LEU A CB  1 ? 
ATOM   1607 C  CG  . LEU A 1 205 ? 21.351  21.053  7.614   1.000 9.674  0 205 LEU A CG  1 ? 
ATOM   1608 C  CD1 . LEU A 1 205 ? 21.204  19.791  8.485   1.000 10.871 0 205 LEU A CD1 1 ? 
ATOM   1609 C  CD2 . LEU A 1 205 ? 21.265  20.655  6.148   1.000 10.016 0 205 LEU A CD2 1 ? 
ATOM   1610 N  N   . LEU A 1 206 ? 18.831  24.932  8.360   1.000 9.003  0 206 LEU A N   1 ? 
ATOM   1611 C  CA  . LEU A 1 206 ? 17.628  25.748  8.460   1.000 9.049  0 206 LEU A CA  1 ? 
ATOM   1612 C  C   . LEU A 1 206 ? 17.531  26.694  7.268   1.000 9.075  0 206 LEU A C   1 ? 
ATOM   1613 O  O   . LEU A 1 206 ? 16.447  26.888  6.706   1.000 9.933  0 206 LEU A O   1 ? 
ATOM   1614 C  CB  . LEU A 1 206 ? 17.638  26.517  9.778   1.000 9.764  0 206 LEU A CB  1 ? 
ATOM   1615 C  CG  . LEU A 1 206 ? 17.447  25.632  11.029  1.000 11.862 0 206 LEU A CG  1 ? 
ATOM   1616 C  CD1 . LEU A 1 206 ? 17.659  26.463  12.285  1.000 14.081 0 206 LEU A CD1 1 ? 
ATOM   1617 C  CD2 . LEU A 1 206 ? 16.100  24.985  11.042  1.000 14.183 0 206 LEU A CD2 1 ? 
ATOM   1618 N  N   . HIS A 1 207 ? 18.683  27.253  6.855   1.000 8.620  0 207 HIS A N   1 ? 
ATOM   1619 C  CA  . HIS A 1 207 ? 18.689  28.049  5.635   1.000 8.667  0 207 HIS A CA  1 ? 
ATOM   1620 C  C   . HIS A 1 207 ? 18.401  27.226  4.382   1.000 9.148  0 207 HIS A C   1 ? 
ATOM   1621 O  O   . HIS A 1 207 ? 17.674  27.711  3.509   1.000 9.948  0 207 HIS A O   1 ? 
ATOM   1622 C  CB  . HIS A 1 207 ? 20.003  28.808  5.542   1.000 8.475  0 207 HIS A CB  1 ? 
ATOM   1623 C  CG  . HIS A 1 207 ? 20.155  29.981  6.431   1.000 8.752  0 207 HIS A CG  1 ? 
ATOM   1624 N  ND1 . HIS A 1 207 ? 20.423  29.885  7.773   1.000 9.529  0 207 HIS A ND1 1 ? 
ATOM   1625 C  CD2 . HIS A 1 207 ? 20.060  31.296  6.148   1.000 9.770  0 207 HIS A CD2 1 ? 
ATOM   1626 C  CE1 . HIS A 1 207 ? 20.549  31.115  8.267   1.000 10.163 0 207 HIS A CE1 1 ? 
ATOM   1627 N  NE2 . HIS A 1 207 ? 20.313  32.006  7.312   1.000 10.735 0 207 HIS A NE2 1 ? 
ATOM   1628 N  N   . VAL A 1 208 ? 18.989  26.038  4.268   1.000 8.288  0 208 VAL A N   1 ? 
ATOM   1629 C  CA  . VAL A 1 208 ? 18.692  25.176  3.123   1.000 8.726  0 208 VAL A CA  1 ? 
ATOM   1630 C  C   . VAL A 1 208 ? 17.210  24.868  3.043   1.000 8.467  0 208 VAL A C   1 ? 
ATOM   1631 O  O   . VAL A 1 208 ? 16.640  24.860  1.949   1.000 9.499  0 208 VAL A O   1 ? 
ATOM   1632 C  CB  . VAL A 1 208 ? 19.541  23.882  3.171   1.000 8.453  0 208 VAL A CB  1 ? 
ATOM   1633 C  CG1 . VAL A 1 208 ? 19.073  22.842  2.160   1.000 9.706  0 208 VAL A CG1 1 ? 
ATOM   1634 C  CG2 . VAL A 1 208 ? 20.988  24.171  2.851   1.000 9.217  0 208 VAL A CG2 1 ? 
ATOM   1635 N  N   . PHE A 1 209 ? 16.549  24.585  4.179   1.000 9.444  0 209 PHE A N   1 ? 
ATOM   1636 C  CA  . PHE A 1 209 ? 15.140  24.229  4.131   1.000 9.614  0 209 PHE A CA  1 ? 
ATOM   1637 C  C   . PHE A 1 209 ? 14.346  25.403  3.515   1.000 10.076 0 209 PHE A C   1 ? 
ATOM   1638 O  O   . PHE A 1 209 ? 13.445  25.182  2.684   1.000 10.368 0 209 PHE A O   1 ? 
ATOM   1639 C  CB  . PHE A 1 209 ? 14.543  23.815  5.480   1.000 10.358 0 209 PHE A CB  1 ? 
ATOM   1640 C  CG  . PHE A 1 209 ? 15.261  22.698  6.213   1.000 10.940 0 209 PHE A CG  1 ? 
ATOM   1641 C  CD1 . PHE A 1 209 ? 16.027  21.743  5.557   1.000 12.172 0 209 PHE A CD1 1 ? 
ATOM   1642 C  CD2 . PHE A 1 209 ? 15.132  22.624  7.597   1.000 10.797 0 209 PHE A CD2 1 ? 
ATOM   1643 C  CE1 . PHE A 1 209 ? 16.701  20.771  6.292   1.000 11.921 0 209 PHE A CE1 1 ? 
ATOM   1644 C  CE2 . PHE A 1 209 ? 15.787  21.622  8.333   1.000 12.762 0 209 PHE A CE2 1 ? 
ATOM   1645 C  CZ  . PHE A 1 209 ? 16.574  20.714  7.646   1.000 11.610 0 209 PHE A CZ  1 ? 
ATOM   1646 N  N   . ASP A 1 210 ? 14.666  26.627  3.945   1.000 10.420 0 210 ASP A N   1 ? 
ATOM   1647 C  CA  . ASP A 1 210 ? 13.907  27.779  3.467   1.000 10.506 0 210 ASP A CA  1 ? 
ATOM   1648 C  C   . ASP A 1 210 ? 14.205  28.035  1.985   1.000 11.469 0 210 ASP A C   1 ? 
ATOM   1649 O  O   . ASP A 1 210 ? 13.298  28.350  1.200   1.000 11.791 0 210 ASP A O   1 ? 
ATOM   1650 C  CB  . ASP A 1 210 ? 14.245  29.012  4.298   1.000 11.696 0 210 ASP A CB  1 ? 
ATOM   1651 C  CG  . ASP A 1 210 ? 13.654  29.036  5.704   1.000 14.097 0 210 ASP A CG  1 ? 
ATOM   1652 O  OD1 . ASP A 1 210 ? 12.876  28.118  6.056   1.000 15.988 0 210 ASP A OD1 1 ? 
ATOM   1653 O  OD2 . ASP A 1 210 ? 14.022  29.970  6.450   1.000 17.049 0 210 ASP A OD2 1 ? 
ATOM   1654 N  N   . GLU A 1 211 ? 15.460  27.888  1.596   1.000 10.407 0 211 GLU A N   1 ? 
ATOM   1655 C  CA  . GLU A 1 211 ? 15.868  28.073  0.208   1.000 10.185 0 211 GLU A CA  1 ? 
ATOM   1656 C  C   . GLU A 1 211 ? 15.258  27.012  -0.706  1.000 11.865 0 211 GLU A C   1 ? 
ATOM   1657 O  O   . GLU A 1 211 ? 14.852  27.297  -1.834  1.000 11.459 0 211 GLU A O   1 ? 
ATOM   1658 C  CB  . GLU A 1 211 ? 17.386  28.038  0.109   1.000 10.791 0 211 GLU A CB  1 ? 
ATOM   1659 C  CG  . GLU A 1 211 ? 17.930  28.210  -1.297  1.000 11.850 0 211 GLU A CG  1 ? 
ATOM   1660 C  CD  . GLU A 1 211 ? 17.814  29.564  -1.919  1.000 13.614 0 211 GLU A CD  1 ? 
ATOM   1661 O  OE1 . GLU A 1 211 ? 17.312  30.529  -1.282  1.000 14.406 0 211 GLU A OE1 1 ? 
ATOM   1662 O  OE2 . GLU A 1 211 ? 18.226  29.623  -3.108  1.000 13.927 0 211 GLU A OE2 1 ? 
ATOM   1663 N  N   . TYR A 1 212 ? 15.207  25.763  -0.238  1.000 11.302 0 212 TYR A N   1 ? 
ATOM   1664 C  CA  . TYR A 1 212 ? 14.587  24.689  -0.998  1.000 11.422 0 212 TYR A CA  1 ? 
ATOM   1665 C  C   . TYR A 1 212 ? 13.120  25.016  -1.260  1.000 12.483 0 212 TYR A C   1 ? 
ATOM   1666 O  O   . TYR A 1 212 ? 12.650  24.779  -2.379  1.000 13.278 0 212 TYR A O   1 ? 
ATOM   1667 C  CB  . TYR A 1 212 ? 14.737  23.384  -0.194  1.000 11.150 0 212 TYR A CB  1 ? 
ATOM   1668 C  CG  . TYR A 1 212 ? 14.184  22.238  -1.019  1.000 10.881 0 212 TYR A CG  1 ? 
ATOM   1669 C  CD1 . TYR A 1 212 ? 14.963  21.619  -1.985  1.000 12.510 0 212 TYR A CD1 1 ? 
ATOM   1670 C  CD2 . TYR A 1 212 ? 12.871  21.820  -0.915  1.000 10.140 0 212 TYR A CD2 1 ? 
ATOM   1671 C  CE1 . TYR A 1 212 ? 14.445  20.624  -2.792  1.000 12.904 0 212 TYR A CE1 1 ? 
ATOM   1672 C  CE2 . TYR A 1 212 ? 12.346  20.821  -1.703  1.000 10.814 0 212 TYR A CE2 1 ? 
ATOM   1673 C  CZ  . TYR A 1 212 ? 13.149  20.229  -2.651  1.000 11.835 0 212 TYR A CZ  1 ? 
ATOM   1674 O  OH  . TYR A 1 212 ? 12.637  19.264  -3.493  1.000 12.804 0 212 TYR A OH  1 ? 
ATOM   1675 N  N   . LYS A 1 213 ? 12.395  25.492  -0.259  1.000 12.964 0 213 LYS A N   1 ? 
ATOM   1676 C  CA  . LYS A 1 213 ? 11.006  25.898  -0.442  1.000 13.774 0 213 LYS A CA  1 ? 
ATOM   1677 C  C   . LYS A 1 213 ? 10.932  27.036  -1.474  1.000 14.040 0 213 LYS A C   1 ? 
ATOM   1678 O  O   . LYS A 1 213 ? 10.052  27.008  -2.347  1.000 15.992 0 213 LYS A O   1 ? 
ATOM   1679 C  CB  . LYS A 1 213 ? 10.317  26.229  0.885   1.000 15.225 0 213 LYS A CB  1 ? 
ATOM   1680 C  CG  . LYS A 1 213 ? 8.946   26.867  0.745   1.000 18.991 0 213 LYS A CG  1 ? 
ATOM   1681 C  CD  . LYS A 1 213 ? 7.929   25.841  0.312   1.000 21.854 0 213 LYS A CD  1 ? 
ATOM   1682 C  CE  . LYS A 1 213 ? 6.522   26.387  0.378   1.000 27.307 0 213 LYS A CE  1 ? 
ATOM   1683 N  NZ  . LYS A 1 213 ? 5.970   26.189  1.717   1.000 32.897 0 213 LYS A NZ  1 ? 
ATOM   1684 N  N   . ARG A 1 214 ? 11.821  28.014  -1.398  1.000 14.169 0 214 ARG A N   1 ? 
ATOM   1685 C  CA  . ARG A 1 214 ? 11.802  29.127  -2.341  1.000 14.480 0 214 ARG A CA  1 ? 
ATOM   1686 C  C   . ARG A 1 214 ? 11.949  28.665  -3.779  1.000 16.109 0 214 ARG A C   1 ? 
ATOM   1687 O  O   . ARG A 1 214 ? 11.170  29.102  -4.655  1.000 17.746 0 214 ARG A O   1 ? 
ATOM   1688 C  CB  . ARG A 1 214 ? 12.914  30.111  -1.987  1.000 14.032 0 214 ARG A CB  1 ? 
ATOM   1689 C  CG  . ARG A 1 214 ? 12.872  31.449  -2.718  1.000 17.188 0 214 ARG A CG  1 ? 
ATOM   1690 C  CD  . ARG A 1 214 ? 14.095  32.291  -2.393  1.000 18.094 0 214 ARG A CD  1 ? 
ATOM   1691 N  NE  . ARG A 1 214 ? 15.325  31.838  -3.064  1.000 18.725 0 214 ARG A NE  1 ? 
ATOM   1692 C  CZ  . ARG A 1 214 ? 15.643  31.882  -4.362  1.000 20.769 0 214 ARG A CZ  1 ? 
ATOM   1693 N  NH1 . ARG A 1 214 ? 14.863  32.505  -5.244  1.000 22.386 0 214 ARG A NH1 1 ? 
ATOM   1694 N  NH2 . ARG A 1 214 ? 16.783  31.396  -4.811  1.000 21.202 0 214 ARG A NH2 1 ? 
ATOM   1695 N  N   . ILE A 1 215 ? 12.848  27.725  -4.089  1.000 13.661 0 215 ILE A N   1 ? 
ATOM   1696 C  CA  . ILE A 1 215 ? 13.138  27.353  -5.461  1.000 14.101 0 215 ILE A CA  1 ? 
ATOM   1697 C  C   . ILE A 1 215 ? 12.225  26.258  -5.978  1.000 15.290 0 215 ILE A C   1 ? 
ATOM   1698 O  O   . ILE A 1 215 ? 12.001  26.220  -7.195  1.000 17.732 0 215 ILE A O   1 ? 
ATOM   1699 C  CB  . ILE A 1 215 ? 14.610  26.965  -5.666  1.000 14.607 0 215 ILE A CB  1 ? 
ATOM   1700 C  CG1 . ILE A 1 215 ? 14.956  25.617  -5.002  1.000 15.271 0 215 ILE A CG1 1 ? 
ATOM   1701 C  CG2 . ILE A 1 215 ? 15.528  28.118  -5.246  1.000 15.394 0 215 ILE A CG2 1 ? 
ATOM   1702 C  CD1 . ILE A 1 215 ? 16.411  25.242  -5.226  1.000 15.789 0 215 ILE A CD1 1 ? 
ATOM   1703 N  N   . SER A 1 216 ? 11.639  25.421  -5.123  1.000 15.826 0 216 SER A N   1 ? 
ATOM   1704 C  CA  . SER A 1 216 ? 10.821  24.282  -5.535  1.000 16.011 0 216 SER A CA  1 ? 
ATOM   1705 C  C   . SER A 1 216 ? 9.316   24.468  -5.310  1.000 15.632 0 216 SER A C   1 ? 
ATOM   1706 O  O   . SER A 1 216 ? 8.527   23.666  -5.819  1.000 17.520 0 216 SER A O   1 ? 
ATOM   1707 C  CB  . SER A 1 216 ? 11.240  23.021  -4.807  1.000 14.602 0 216 SER A CB  1 ? 
ATOM   1708 O  OG  . SER A 1 216 ? 10.767  23.016  -3.467  1.000 15.718 0 216 SER A OG  1 ? 
ATOM   1709 N  N   . GLN A 1 217 ? 8.922   25.403  -4.428  1.000 16.022 0 217 GLN A N   1 ? 
ATOM   1710 C  CA  . GLN A 1 217 ? 7.568   25.612  -3.940  1.000 17.361 0 217 GLN A CA  1 ? 
ATOM   1711 C  C   . GLN A 1 217 ? 7.073   24.445  -3.081  1.000 18.841 0 217 GLN A C   1 ? 
ATOM   1712 O  O   . GLN A 1 217 ? 5.876   24.329  -2.791  1.000 21.267 0 217 GLN A O   1 ? 
ATOM   1713 C  CB  . GLN A 1 217 ? 6.458   25.894  -4.965  1.000 22.394 0 217 GLN A CB  1 ? 
ATOM   1714 C  CG  . GLN A 1 217 ? 6.861   26.616  -6.244  1.000 31.485 0 217 GLN A CG  1 ? 
ATOM   1715 C  CD  . GLN A 1 217 ? 7.671   27.856  -6.015  1.000 35.872 0 217 GLN A CD  1 ? 
ATOM   1716 O  OE1 . GLN A 1 217 ? 8.647   28.134  -6.719  1.000 40.814 0 217 GLN A OE1 1 ? 
ATOM   1717 N  NE2 . GLN A 1 217 ? 7.291   28.586  -4.981  1.000 46.519 0 217 GLN A NE2 1 ? 
ATOM   1718 N  N   . LYS A 1 218 ? 7.990   23.580  -2.628  1.000 15.332 0 218 LYS A N   1 ? 
ATOM   1719 C  CA  . LYS A 1 218 ? 7.671   22.448  -1.783  1.000 15.810 0 218 LYS A CA  1 ? 
ATOM   1720 C  C   . LYS A 1 218 ? 8.529   22.512  -0.524  1.000 13.584 0 218 LYS A C   1 ? 
ATOM   1721 O  O   . LYS A 1 218 ? 9.672   22.914  -0.581  1.000 13.941 0 218 LYS A O   1 ? 
ATOM   1722 C  CB  . LYS A 1 218 ? 7.936   21.132  -2.524  1.000 18.098 0 218 LYS A CB  1 ? 
ATOM   1723 C  CG  . LYS A 1 218 ? 7.080   20.897  -3.778  1.000 24.047 0 218 LYS A CG  1 ? 
ATOM   1724 C  CD  . LYS A 1 218 ? 5.639   20.568  -3.431  1.000 29.463 0 218 LYS A CD  1 ? 
ATOM   1725 C  CE  . LYS A 1 218 ? 5.547   19.103  -3.114  1.000 37.783 0 218 LYS A CE  1 ? 
ATOM   1726 N  NZ  . LYS A 1 218 ? 4.195   18.576  -2.882  1.000 40.614 0 218 LYS A NZ  1 ? 
ATOM   1727 N  N   . ASP A 1 219 ? 7.950   22.108  0.591   1.000 14.177 0 219 ASP A N   1 ? 
ATOM   1728 C  CA  . ASP A 1 219 ? 8.756   21.872  1.771   1.000 14.041 0 219 ASP A CA  1 ? 
ATOM   1729 C  C   . ASP A 1 219 ? 9.681   20.685  1.507   1.000 12.300 0 219 ASP A C   1 ? 
ATOM   1730 O  O   . ASP A 1 219 ? 9.350   19.738  0.809   1.000 12.791 0 219 ASP A O   1 ? 
ATOM   1731 C  CB  . ASP A 1 219 ? 7.879   21.584  2.986   1.000 17.248 0 219 ASP A CB  1 ? 
ATOM   1732 C  CG  . ASP A 1 219 ? 6.744   22.541  3.325   1.000 26.543 0 219 ASP A CG  1 ? 
ATOM   1733 O  OD1 . ASP A 1 219 ? 7.000   23.747  3.417   1.000 25.205 0 219 ASP A OD1 1 ? 
ATOM   1734 O  OD2 . ASP A 1 219 ? 5.635   22.038  3.648   1.000 33.051 0 219 ASP A OD2 1 ? 
ATOM   1735 N  N   . ILE A 1 220 ? 10.839  20.694  2.152   1.000 11.423 0 220 ILE A N   1 ? 
ATOM   1736 C  CA  . ILE A 1 220 ? 11.750  19.569  1.983   1.000 11.706 0 220 ILE A CA  1 ? 
ATOM   1737 C  C   . ILE A 1 220 ? 11.112  18.249  2.445   1.000 10.794 0 220 ILE A C   1 ? 
ATOM   1738 O  O   . ILE A 1 220 ? 11.348  17.220  1.819   1.000 10.939 0 220 ILE A O   1 ? 
ATOM   1739 C  CB  . ILE A 1 220 ? 13.124  19.830  2.644   1.000 12.057 0 220 ILE A CB  1 ? 
ATOM   1740 C  CG1 . ILE A 1 220 ? 14.151  18.793  2.189   1.000 14.036 0 220 ILE A CG1 1 ? 
ATOM   1741 C  CG2 . ILE A 1 220 ? 13.029  19.875  4.155   1.000 12.690 0 220 ILE A CG2 1 ? 
ATOM   1742 C  CD1 . ILE A 1 220 ? 15.535  18.982  2.754   1.000 15.701 0 220 ILE A CD1 1 ? 
ATOM   1743 N  N   . GLU A 1 221 ? 10.250  18.278  3.448   1.000 11.563 0 221 GLU A N   1 ? 
ATOM   1744 C  CA  . GLU A 1 221 ? 9.604   17.055  3.914   1.000 11.632 0 221 GLU A CA  1 ? 
ATOM   1745 C  C   . GLU A 1 221 ? 8.688   16.482  2.823   1.000 12.748 0 221 GLU A C   1 ? 
ATOM   1746 O  O   . GLU A 1 221 ? 8.562   15.267  2.688   1.000 12.963 0 221 GLU A O   1 ? 
ATOM   1747 C  CB  . GLU A 1 221 ? 8.726   17.305  5.143   1.000 13.495 0 221 GLU A CB  1 ? 
ATOM   1748 C  CG  . GLU A 1 221 ? 9.510   17.661  6.393   1.000 14.439 0 221 GLU A CG  1 ? 
ATOM   1749 C  CD  . GLU A 1 221 ? 9.702   19.143  6.604   1.000 15.180 0 221 GLU A CD  1 ? 
ATOM   1750 O  OE1 . GLU A 1 221 ? 9.830   19.885  5.597   1.000 15.446 0 221 GLU A OE1 1 ? 
ATOM   1751 O  OE2 . GLU A 1 221 ? 9.723   19.526  7.829   1.000 16.321 0 221 GLU A OE2 1 ? 
ATOM   1752 N  N   . GLN A 1 222 ? 7.987   17.356  2.084   1.000 12.237 0 222 GLN A N   1 ? 
ATOM   1753 C  CA  . GLN A 1 222 ? 7.130   16.879  1.004   1.000 13.239 0 222 GLN A CA  1 ? 
ATOM   1754 C  C   . GLN A 1 222 ? 7.952   16.132  -0.039  1.000 13.188 0 222 GLN A C   1 ? 
ATOM   1755 O  O   . GLN A 1 222 ? 7.538   15.070  -0.495  1.000 14.590 0 222 GLN A O   1 ? 
ATOM   1756 C  CB  . GLN A 1 222 ? 6.433   18.043  0.302   1.000 16.126 0 222 GLN A CB  1 ? 
ATOM   1757 C  CG  . GLN A 1 222 ? 5.328   18.688  1.128   1.000 19.451 0 222 GLN A CG  1 ? 
ATOM   1758 C  CD  . GLN A 1 222 ? 4.738   19.906  0.461   1.000 22.676 0 222 GLN A CD  1 ? 
ATOM   1759 O  OE1 . GLN A 1 222 ? 5.322   20.986  0.451   1.000 21.497 0 222 GLN A OE1 1 ? 
ATOM   1760 N  NE2 . GLN A 1 222 ? 3.570   19.728  -0.144  1.000 26.708 0 222 GLN A NE2 1 ? 
ATOM   1761 N  N   . SER A 1 223 ? 9.095   16.693  -0.444  1.000 12.980 0 223 SER A N   1 ? 
ATOM   1762 C  CA  . SER A 1 223 ? 9.963   16.044  -1.421  1.000 12.689 0 223 SER A CA  1 ? 
ATOM   1763 C  C   . SER A 1 223 ? 10.573  14.762  -0.867  1.000 13.094 0 223 SER A C   1 ? 
ATOM   1764 O  O   . SER A 1 223 ? 10.703  13.762  -1.576  1.000 12.083 0 223 SER A O   1 ? 
ATOM   1765 C  CB  . SER A 1 223 ? 11.021  16.980  -1.876  1.000 12.975 0 223 SER A CB  1 ? 
ATOM   1766 O  OG  . SER A 1 223 ? 10.427  18.078  -2.563  1.000 14.726 0 223 SER A OG  1 ? 
ATOM   1767 N  N   . ILE A 1 224 ? 11.021  14.753  0.397   1.000 11.340 0 224 ILE A N   1 ? 
ATOM   1768 C  CA  . ILE A 1 224 ? 11.524  13.507  0.969   1.000 11.192 0 224 ILE A CA  1 ? 
ATOM   1769 C  C   . ILE A 1 224 ? 10.472  12.408  0.875   1.000 12.370 0 224 ILE A C   1 ? 
ATOM   1770 O  O   . ILE A 1 224 ? 10.779  11.263  0.538   1.000 12.263 0 224 ILE A O   1 ? 
ATOM   1771 C  CB  . ILE A 1 224 ? 11.994  13.746  2.412   1.000 9.793  0 224 ILE A CB  1 ? 
ATOM   1772 C  CG1 . ILE A 1 224 ? 13.249  14.598  2.405   1.000 10.492 0 224 ILE A CG1 1 ? 
ATOM   1773 C  CG2 . ILE A 1 224 ? 12.199  12.422  3.143   1.000 10.511 0 224 ILE A CG2 1 ? 
ATOM   1774 C  CD1 . ILE A 1 224 ? 13.624  15.144  3.772   1.000 10.648 0 224 ILE A CD1 1 ? 
ATOM   1775 N  N   . LYS A 1 225 ? 9.219   12.744  1.210   1.000 11.905 0 225 LYS A N   1 ? 
ATOM   1776 C  CA  . LYS A 1 225 ? 8.148   11.735  1.212   1.000 13.425 0 225 LYS A CA  1 ? 
ATOM   1777 C  C   . LYS A 1 225 ? 7.876   11.196  -0.190  1.000 14.333 0 225 LYS A C   1 ? 
ATOM   1778 O  O   . LYS A 1 225 ? 7.571   10.001  -0.310  1.000 16.152 0 225 LYS A O   1 ? 
ATOM   1779 C  CB  . LYS A 1 225 ? 6.884   12.330  1.848   1.000 13.584 0 225 LYS A CB  1 ? 
ATOM   1780 C  CG  . LYS A 1 225 ? 6.966   12.466  3.339   1.000 16.135 0 225 LYS A CG  1 ? 
ATOM   1781 C  CD  . LYS A 1 225 ? 5.777   13.232  3.903   1.000 20.033 0 225 LYS A CD  1 ? 
ATOM   1782 C  CE  . LYS A 1 225 ? 6.032   13.544  5.307   1.000 23.378 0 225 LYS A CE  1 ? 
ATOM   1783 N  NZ  . LYS A 1 225 ? 4.907   14.321  5.849   1.000 29.595 0 225 LYS A NZ  1 ? 
ATOM   1784 N  N   . SER A 1 226 ? 7.966   12.046  -1.218  1.000 13.904 0 226 SER A N   1 ? 
ATOM   1785 C  CA  . SER A 1 226 ? 7.634   11.590  -2.562  1.000 15.525 0 226 SER A CA  1 ? 
ATOM   1786 C  C   . SER A 1 226 ? 8.819   10.932  -3.262  1.000 15.856 0 226 SER A C   1 ? 
ATOM   1787 O  O   . SER A 1 226 ? 8.604   10.181  -4.208  1.000 18.424 0 226 SER A O   1 ? 
ATOM   1788 C  CB  . SER A 1 226 ? 7.020   12.678  -3.373  1.000 17.942 0 226 SER A CB  1 ? 
ATOM   1789 O  OG  . SER A 1 226 ? 8.003   13.600  -3.744  1.000 21.517 0 226 SER A OG  1 ? 
ATOM   1790 N  N   . GLU A 1 227 ? 10.069  11.185  -2.846  1.000 12.316 0 227 GLU A N   1 ? 
ATOM   1791 C  CA  . GLU A 1 227 ? 11.264  10.832  -3.603  1.000 12.734 0 227 GLU A CA  1 ? 
ATOM   1792 C  C   . GLU A 1 227 ? 12.118  9.763   -2.932  1.000 11.794 0 227 GLU A C   1 ? 
ATOM   1793 O  O   . GLU A 1 227 ? 13.070  9.287   -3.559  1.000 12.713 0 227 GLU A O   1 ? 
ATOM   1794 C  CB  . GLU A 1 227 ? 12.137  12.080  -3.790  1.000 14.102 0 227 GLU A CB  1 ? 
ATOM   1795 C  CG  . GLU A 1 227 ? 11.427  13.161  -4.601  1.000 14.671 0 227 GLU A CG  1 ? 
ATOM   1796 C  CD  . GLU A 1 227 ? 12.086  14.527  -4.651  1.000 17.950 0 227 GLU A CD  1 ? 
ATOM   1797 O  OE1 . GLU A 1 227 ? 13.202  14.696  -4.135  1.000 17.646 0 227 GLU A OE1 1 ? 
ATOM   1798 O  OE2 . GLU A 1 227 ? 11.521  15.420  -5.293  1.000 20.410 0 227 GLU A OE2 1 ? 
ATOM   1799 N  N   . THR A 1 228 ? 11.779  9.412   -1.683  1.000 12.062 0 228 THR A N   1 ? 
ATOM   1800 C  CA  . THR A 1 228 ? 12.471  8.352   -0.967  1.000 11.661 0 228 THR A CA  1 ? 
ATOM   1801 C  C   . THR A 1 228 ? 11.424  7.508   -0.269  1.000 12.208 0 228 THR A C   1 ? 
ATOM   1802 O  O   . THR A 1 228 ? 10.256  7.886   -0.149  1.000 13.310 0 228 THR A O   1 ? 
ATOM   1803 C  CB  . THR A 1 228 ? 13.477  8.931   0.036   1.000 13.743 0 228 THR A CB  1 ? 
ATOM   1804 O  OG1 . THR A 1 228 ? 12.805  9.540   1.147   1.000 11.973 0 228 THR A OG1 1 ? 
ATOM   1805 C  CG2 . THR A 1 228 ? 14.457  9.925   -0.569  1.000 13.373 0 228 THR A CG2 1 ? 
ATOM   1806 N  N   . SER A 1 229 ? 11.872  6.353   0.248   1.000 12.263 0 229 SER A N   1 ? 
ATOM   1807 C  CA  . SER A 1 229 ? 10.956  5.430   0.902   1.000 13.088 0 229 SER A CA  1 ? 
ATOM   1808 C  C   . SER A 1 229 ? 11.612  4.682   2.056   1.000 12.577 0 229 SER A C   1 ? 
ATOM   1809 O  O   . SER A 1 229 ? 12.822  4.772   2.301   1.000 12.337 0 229 SER A O   1 ? 
ATOM   1810 C  CB  . SER A 1 229 ? 10.351  4.416   -0.077  1.000 15.547 0 229 SER A CB  1 ? 
ATOM   1811 O  OG  . SER A 1 229 ? 11.396  3.652   -0.617  1.000 19.948 0 229 SER A OG  1 ? 
ATOM   1812 N  N   . GLY A 1 230 ? 10.771  4.001   2.820   1.000 13.108 0 230 GLY A N   1 ? 
ATOM   1813 C  CA  . GLY A 1 230 ? 11.247  3.052   3.812   1.000 12.863 0 230 GLY A CA  1 ? 
ATOM   1814 C  C   . GLY A 1 230 ? 11.980  3.725   4.970   1.000 10.942 0 230 GLY A C   1 ? 
ATOM   1815 O  O   . GLY A 1 230 ? 11.691  4.870   5.326   1.000 10.635 0 230 GLY A O   1 ? 
ATOM   1816 N  N   . SER A 1 231 ? 12.911  2.977   5.568   1.000 11.005 0 231 SER A N   1 ? 
ATOM   1817 C  CA  . SER A 1 231 ? 13.617  3.504   6.728   1.000 11.468 0 231 SER A CA  1 ? 
ATOM   1818 C  C   . SER A 1 231 ? 14.542  4.657   6.371   1.000 10.293 0 231 SER A C   1 ? 
ATOM   1819 O  O   . SER A 1 231 ? 14.718  5.513   7.212   1.000 9.780  0 231 SER A O   1 ? 
ATOM   1820 C  CB  . SER A 1 231 ? 14.347  2.420   7.454   1.000 13.386 0 231 SER A CB  1 ? 
ATOM   1821 O  OG  . SER A 1 231 ? 13.422  1.584   8.164   1.000 19.271 0 231 SER A OG  1 ? 
ATOM   1822 N  N   . PHE A 1 232 ? 15.090  4.687   5.161   1.000 10.304 0 232 PHE A N   1 ? 
ATOM   1823 C  CA  . PHE A 1 232 ? 15.871  5.831   4.722   1.000 9.943  0 232 PHE A CA  1 ? 
ATOM   1824 C  C   . PHE A 1 232 ? 15.024  7.098   4.753   1.000 9.527  0 232 PHE A C   1 ? 
ATOM   1825 O  O   . PHE A 1 232 ? 15.437  8.112   5.328   1.000 9.149  0 232 PHE A O   1 ? 
ATOM   1826 C  CB  . PHE A 1 232 ? 16.416  5.604   3.320   1.000 9.880  0 232 PHE A CB  1 ? 
ATOM   1827 C  CG  . PHE A 1 232 ? 17.281  6.723   2.758   1.000 9.086  0 232 PHE A CG  1 ? 
ATOM   1828 C  CD1 . PHE A 1 232 ? 18.436  7.177   3.391   1.000 8.650  0 232 PHE A CD1 1 ? 
ATOM   1829 C  CD2 . PHE A 1 232 ? 16.898  7.332   1.579   1.000 10.384 0 232 PHE A CD2 1 ? 
ATOM   1830 C  CE1 . PHE A 1 232 ? 19.189  8.187   2.843   1.000 9.569  0 232 PHE A CE1 1 ? 
ATOM   1831 C  CE2 . PHE A 1 232 ? 17.670  8.338   1.026   1.000 10.142 0 232 PHE A CE2 1 ? 
ATOM   1832 C  CZ  . PHE A 1 232 ? 18.817  8.780   1.656   1.000 9.699  0 232 PHE A CZ  1 ? 
ATOM   1833 N  N   . GLU A 1 233 ? 13.824  7.080   4.175   1.000 9.623  0 233 GLU A N   1 ? 
ATOM   1834 C  CA  . GLU A 1 233 ? 12.904  8.198   4.243   1.000 9.509  0 233 GLU A CA  1 ? 
ATOM   1835 C  C   . GLU A 1 233 ? 12.663  8.607   5.707   1.000 9.136  0 233 GLU A C   1 ? 
ATOM   1836 O  O   . GLU A 1 233 ? 12.719  9.793   6.051   1.000 9.609  0 233 GLU A O   1 ? 
ATOM   1837 C  CB  . GLU A 1 233 ? 11.575  7.787   3.605   1.000 11.112 0 233 GLU A CB  1 ? 
ATOM   1838 C  CG  . GLU A 1 233 ? 10.493  8.862   3.727   1.000 11.787 0 233 GLU A CG  1 ? 
ATOM   1839 C  CD  . GLU A 1 233 ? 9.092   8.423   3.326   1.000 14.861 0 233 GLU A CD  1 ? 
ATOM   1840 O  OE1 . GLU A 1 233 ? 8.961   7.267   2.902   1.000 17.296 0 233 GLU A OE1 1 ? 
ATOM   1841 O  OE2 . GLU A 1 233 ? 8.121   9.220   3.516   1.000 16.416 0 233 GLU A OE2 1 ? 
ATOM   1842 N  N   . ASP A 1 234 ? 12.382  7.620   6.568   1.000 8.857  0 234 ASP A N   1 ? 
ATOM   1843 C  CA  . ASP A 1 234 ? 12.047  7.955   7.941   1.000 9.820  0 234 ASP A CA  1 ? 
ATOM   1844 C  C   . ASP A 1 234 ? 13.238  8.637   8.613   1.000 8.763  0 234 ASP A C   1 ? 
ATOM   1845 O  O   . ASP A 1 234 ? 13.104  9.552   9.421   1.000 9.857  0 234 ASP A O   1 ? 
ATOM   1846 C  CB  . ASP A 1 234 ? 11.600  6.725   8.729   1.000 11.410 0 234 ASP A CB  1 ? 
ATOM   1847 C  CG  . ASP A 1 234 ? 10.287  6.115   8.294   1.000 15.640 0 234 ASP A CG  1 ? 
ATOM   1848 O  OD1 . ASP A 1 234 ? 9.524   6.865   7.684   1.000 18.728 0 234 ASP A OD1 1 ? 
ATOM   1849 O  OD2 . ASP A 1 234 ? 10.183  4.886   8.507   1.000 19.879 0 234 ASP A OD2 1 ? 
ATOM   1850 N  N   . ALA A 1 235 ? 14.453  8.166   8.349   1.000 8.526  0 235 ALA A N   1 ? 
ATOM   1851 C  CA  . ALA A 1 235 ? 15.661  8.713   8.956   1.000 9.129  0 235 ALA A CA  1 ? 
ATOM   1852 C  C   . ALA A 1 235 ? 15.860  10.153  8.508   1.000 8.487  0 235 ALA A C   1 ? 
ATOM   1853 O  O   . ALA A 1 235 ? 16.209  11.011  9.301   1.000 8.901  0 235 ALA A O   1 ? 
ATOM   1854 C  CB  . ALA A 1 235 ? 16.830  7.866   8.572   1.000 8.718  0 235 ALA A CB  1 ? 
ATOM   1855 N  N   . LEU A 1 236 ? 15.675  10.416  7.198   1.000 8.508  0 236 LEU A N   1 ? 
ATOM   1856 C  CA  . LEU A 1 236 ? 15.804  11.781  6.698   1.000 8.753  0 236 LEU A CA  1 ? 
ATOM   1857 C  C   . LEU A 1 236 ? 14.804  12.732  7.351   1.000 8.837  0 236 LEU A C   1 ? 
ATOM   1858 O  O   . LEU A 1 236 ? 15.147  13.874  7.727   1.000 8.423  0 236 LEU A O   1 ? 
ATOM   1859 C  CB  . LEU A 1 236 ? 15.670  11.868  5.174   1.000 8.325  0 236 LEU A CB  1 ? 
ATOM   1860 C  CG  . LEU A 1 236 ? 16.704  11.092  4.353   1.000 9.215  0 236 LEU A CG  1 ? 
ATOM   1861 C  CD1 . LEU A 1 236 ? 16.397  11.335  2.856   1.000 10.268 0 236 LEU A CD1 1 ? 
ATOM   1862 C  CD2 . LEU A 1 236 ? 18.127  11.471  4.667   1.000 9.852  0 236 LEU A CD2 1 ? 
ATOM   1863 N  N   . LEU A 1 237 ? 13.544  12.290  7.436   1.000 8.556  0 237 LEU A N   1 ? 
ATOM   1864 C  CA  . LEU A 1 237 ? 12.522  13.097  8.092   1.000 9.110  0 237 LEU A CA  1 ? 
ATOM   1865 C  C   . LEU A 1 237 ? 12.833  13.385  9.550   1.000 9.074  0 237 LEU A C   1 ? 
ATOM   1866 O  O   . LEU A 1 237 ? 12.574  14.502  10.031  1.000 8.843  0 237 LEU A O   1 ? 
ATOM   1867 C  CB  . LEU A 1 237 ? 11.163  12.407  7.981   1.000 9.185  0 237 LEU A CB  1 ? 
ATOM   1868 C  CG  . LEU A 1 237 ? 10.539  12.368  6.577   1.000 10.885 0 237 LEU A CG  1 ? 
ATOM   1869 C  CD1 . LEU A 1 237 ? 9.282   11.479  6.633   1.000 10.922 0 237 LEU A CD1 1 ? 
ATOM   1870 C  CD2 . LEU A 1 237 ? 10.246  13.766  6.018   1.000 11.825 0 237 LEU A CD2 1 ? 
ATOM   1871 N  N   . ALA A 1 238 ? 13.369  12.378  10.269  1.000 8.118  0 238 ALA A N   1 ? 
ATOM   1872 C  CA  . ALA A 1 238 ? 13.702  12.625  11.669  1.000 7.751  0 238 ALA A CA  1 ? 
ATOM   1873 C  C   . ALA A 1 238 ? 14.798  13.690  11.782  1.000 8.157  0 238 ALA A C   1 ? 
ATOM   1874 O  O   . ALA A 1 238 ? 14.748  14.526  12.680  1.000 8.650  0 238 ALA A O   1 ? 
ATOM   1875 C  CB  . ALA A 1 238 ? 14.148  11.354  12.356  1.000 8.946  0 238 ALA A CB  1 ? 
ATOM   1876 N  N   . ILE A 1 239 ? 15.814  13.639  10.892  1.000 7.877  0 239 ILE A N   1 ? 
ATOM   1877 C  CA  . ILE A 1 239 ? 16.852  14.658  10.940  1.000 8.338  0 239 ILE A CA  1 ? 
ATOM   1878 C  C   . ILE A 1 239 ? 16.258  16.033  10.669  1.000 8.114  0 239 ILE A C   1 ? 
ATOM   1879 O  O   . ILE A 1 239 ? 16.540  17.000  11.371  1.000 8.281  0 239 ILE A O   1 ? 
ATOM   1880 C  CB  . ILE A 1 239 ? 17.993  14.361  9.950   1.000 8.345  0 239 ILE A CB  1 ? 
ATOM   1881 C  CG1 . ILE A 1 239 ? 18.737  13.102  10.349  1.000 8.528  0 239 ILE A CG1 1 ? 
ATOM   1882 C  CG2 . ILE A 1 239 ? 18.933  15.567  9.822   1.000 8.968  0 239 ILE A CG2 1 ? 
ATOM   1883 C  CD1 . ILE A 1 239 ? 19.677  12.571  9.273   1.000 8.967  0 239 ILE A CD1 1 ? 
ATOM   1884 N  N   . VAL A 1 240 ? 15.402  16.156  9.639   1.000 8.528  0 240 VAL A N   1 ? 
ATOM   1885 C  CA  . VAL A 1 240 ? 14.790  17.436  9.338   1.000 9.138  0 240 VAL A CA  1 ? 
ATOM   1886 C  C   . VAL A 1 240 ? 14.019  17.963  10.546  1.000 8.240  0 240 VAL A C   1 ? 
ATOM   1887 O  O   . VAL A 1 240 ? 14.167  19.119  10.943  1.000 8.269  0 240 VAL A O   1 ? 
ATOM   1888 C  CB  . VAL A 1 240 ? 13.915  17.372  8.082   1.000 9.001  0 240 VAL A CB  1 ? 
ATOM   1889 C  CG1 . VAL A 1 240 ? 13.062  18.633  7.925   1.000 10.592 0 240 VAL A CG1 1 ? 
ATOM   1890 C  CG2 . VAL A 1 240 ? 14.771  17.108  6.834   1.000 9.598  0 240 VAL A CG2 1 ? 
ATOM   1891 N  N   . LYS A 1 241 ? 13.180  17.094  11.134  1.000 8.507  0 241 LYS A N   1 ? 
ATOM   1892 C  CA  . LYS A 1 241 ? 12.336  17.498  12.244  1.000 8.703  0 241 LYS A CA  1 ? 
ATOM   1893 C  C   . LYS A 1 241 ? 13.180  17.906  13.437  1.000 8.576  0 241 LYS A C   1 ? 
ATOM   1894 O  O   . LYS A 1 241 ? 12.888  18.894  14.129  1.000 8.921  0 241 LYS A O   1 ? 
ATOM   1895 C  CB  . LYS A 1 241 ? 11.337  16.392  12.583  1.000 10.148 0 241 LYS A CB  1 ? 
ATOM   1896 C  CG  . LYS A 1 241 ? 10.280  16.216  11.501  1.000 11.951 0 241 LYS A CG  1 ? 
ATOM   1897 C  CD  . LYS A 1 241 ? 9.451   14.932  11.624  1.000 13.362 0 241 LYS A CD  1 ? 
ATOM   1898 C  CE  . LYS A 1 241 ? 8.490   14.662  10.487  1.000 18.251 0 241 LYS A CE  1 ? 
ATOM   1899 N  NZ  . LYS A 1 241 ? 7.364   15.585  10.465  1.000 25.727 0 241 LYS A NZ  1 ? 
ATOM   1900 N  N   . CYS A 1 242 ? 14.206  17.133  13.773  1.000 8.130  0 242 CYS A N   1 ? 
ATOM   1901 C  CA  . CYS A 1 242 ? 15.085  17.474  14.872  1.000 8.743  0 242 CYS A CA  1 ? 
ATOM   1902 C  C   . CYS A 1 242 ? 15.822  18.774  14.646  1.000 9.070  0 242 CYS A C   1 ? 
ATOM   1903 O  O   . CYS A 1 242 ? 16.000  19.573  15.577  1.000 10.456 0 242 CYS A O   1 ? 
ATOM   1904 C  CB  . CYS A 1 242 ? 16.044  16.336  15.127  1.000 8.246  0 242 CYS A CB  1 ? 
ATOM   1905 S  SG  . CYS A 1 242 ? 15.307  14.953  16.048  1.000 9.420  0 242 CYS A SG  1 ? 
ATOM   1906 N  N   . MET A 1 243 ? 16.239  19.029  13.390  1.000 8.535  0 243 MET A N   1 ? 
ATOM   1907 C  CA  . MET A 1 243 ? 16.874  20.318  13.072  1.000 8.659  0 243 MET A CA  1 ? 
ATOM   1908 C  C   . MET A 1 243 ? 15.884  21.478  13.211  1.000 8.213  0 243 MET A C   1 ? 
ATOM   1909 O  O   . MET A 1 243 ? 16.283  22.536  13.689  1.000 9.864  0 243 MET A O   1 ? 
ATOM   1910 C  CB  . MET A 1 243 ? 17.497  20.328  11.662  1.000 9.018  0 243 MET A CB  1 ? 
ATOM   1911 C  CG  . MET A 1 243 ? 18.669  19.383  11.573  1.000 9.806  0 243 MET A CG  1 ? 
ATOM   1912 S  SD  . MET A 1 243 ? 20.066  19.971  12.504  1.000 11.511 0 243 MET A SD  1 ? 
ATOM   1913 C  CE  . MET A 1 243 ? 21.244  18.626  12.356  1.000 12.556 0 243 MET A CE  1 ? 
ATOM   1914 N  N   . ARG A 1 244 ? 14.646  21.301  12.818  1.000 8.280  0 244 ARG A N   1 ? 
ATOM   1915 C  CA  . ARG A 1 244 ? 13.675  22.381  12.973  1.000 8.611  0 244 ARG A CA  1 ? 
ATOM   1916 C  C   . ARG A 1 244 ? 13.332  22.658  14.436  1.000 8.441  0 244 ARG A C   1 ? 
ATOM   1917 O  O   . ARG A 1 244 ? 13.411  23.821  14.888  1.000 10.235 0 244 ARG A O   1 ? 
ATOM   1918 C  CB  . ARG A 1 244 ? 12.377  22.124  12.207  1.000 8.989  0 244 ARG A CB  1 ? 
ATOM   1919 C  CG  . ARG A 1 244 ? 12.528  22.044  10.691  1.000 10.697 0 244 ARG A CG  1 ? 
ATOM   1920 C  CD  . ARG A 1 244 ? 11.168  21.975  10.050  1.000 11.076 0 244 ARG A CD  1 ? 
ATOM   1921 N  NE  . ARG A 1 244 ? 11.145  21.857  8.598   1.000 13.050 0 244 ARG A NE  1 ? 
ATOM   1922 C  CZ  . ARG A 1 244 ? 11.263  22.741  7.661   1.000 13.065 0 244 ARG A CZ  1 ? 
ATOM   1923 N  NH1 . ARG A 1 244 ? 11.623  23.963  7.950   1.000 16.638 0 244 ARG A NH1 1 ? 
ATOM   1924 N  NH2 . ARG A 1 244 ? 11.038  22.460  6.407   1.000 14.860 0 244 ARG A NH2 1 ? 
ATOM   1925 N  N   . ASN A 1 245 ? 13.005  21.577  15.176  1.000 9.067  0 245 ASN A N   1 ? 
ATOM   1926 C  CA  . ASN A 1 245 ? 12.674  21.685  16.590  1.000 9.610  0 245 ASN A CA  1 ? 
ATOM   1927 C  C   . ASN A 1 245 ? 12.551  20.284  17.195  1.000 8.807  0 245 ASN A C   1 ? 
ATOM   1928 O  O   . ASN A 1 245 ? 11.667  19.513  16.829  1.000 8.728  0 245 ASN A O   1 ? 
ATOM   1929 C  CB  . ASN A 1 245 ? 11.371  22.441  16.817  1.000 10.865 0 245 ASN A CB  1 ? 
ATOM   1930 C  CG  . ASN A 1 245 ? 11.144  22.727  18.276  1.000 13.003 0 245 ASN A CG  1 ? 
ATOM   1931 O  OD1 . ASN A 1 245 ? 10.718  21.864  19.049  1.000 12.017 0 245 ASN A OD1 1 ? 
ATOM   1932 N  ND2 . ASN A 1 245 ? 11.448  23.947  18.691  1.000 16.740 0 245 ASN A ND2 1 ? 
ATOM   1933 N  N   . LYS A 1 246 ? 13.504  19.944  18.065  1.000 9.254  0 246 LYS A N   1 ? 
ATOM   1934 C  CA  . LYS A 1 246 ? 13.590  18.604  18.634  1.000 10.801 0 246 LYS A CA  1 ? 
ATOM   1935 C  C   . LYS A 1 246 ? 12.356  18.297  19.489  1.000 10.133 0 246 LYS A C   1 ? 
ATOM   1936 O  O   . LYS A 1 246 ? 11.855  17.166  19.501  1.000 9.995  0 246 LYS A O   1 ? 
ATOM   1937 C  CB  . LYS A 1 246 ? 14.832  18.385  19.493  1.000 13.303 0 246 LYS A CB  1 ? 
ATOM   1938 C  CG  . LYS A 1 246 ? 16.124  18.206  18.743  1.000 15.212 0 246 LYS A CG  1 ? 
ATOM   1939 C  CD  . LYS A 1 246 ? 17.253  17.800  19.699  1.000 17.022 0 246 LYS A CD  1 ? 
ATOM   1940 C  CE  . LYS A 1 246 ? 18.459  17.733  18.883  1.000 19.833 0 246 LYS A CE  1 ? 
ATOM   1941 N  NZ  . LYS A 1 246 ? 19.611  17.418  19.714  1.000 20.157 0 246 LYS A NZ  1 ? 
ATOM   1942 N  N   . SER A 1 247 ? 11.847  19.305  20.214  1.000 10.172 0 247 SER A N   1 ? 
ATOM   1943 C  CA  . SER A 1 247 ? 10.669  19.078  21.070  1.000 10.470 0 247 SER A CA  1 ? 
ATOM   1944 C  C   . SER A 1 247 ? 9.434   18.707  20.246  1.000 10.266 0 247 SER A C   1 ? 
ATOM   1945 O  O   . SER A 1 247 ? 8.656   17.833  20.638  1.000 10.606 0 247 SER A O   1 ? 
ATOM   1946 C  CB  . SER A 1 247 ? 10.399  20.254  21.985  1.000 12.130 0 247 SER A CB  1 ? 
ATOM   1947 O  OG  . SER A 1 247 ? 11.565  20.558  22.741  1.000 15.617 0 247 SER A OG  1 ? 
ATOM   1948 N  N   . ALA A 1 248 ? 9.262   19.350  19.081  1.000 9.619  0 248 ALA A N   1 ? 
ATOM   1949 C  CA  . ALA A 1 248 ? 8.185   18.986  18.182  1.000 10.292 0 248 ALA A CA  1 ? 
ATOM   1950 C  C   . ALA A 1 248 ? 8.334   17.563  17.646  1.000 9.406  0 248 ALA A C   1 ? 
ATOM   1951 O  O   . ALA A 1 248 ? 7.358   16.867  17.459  1.000 9.879  0 248 ALA A O   1 ? 
ATOM   1952 C  CB  . ALA A 1 248 ? 8.076   19.966  17.025  1.000 9.707  0 248 ALA A CB  1 ? 
ATOM   1953 N  N   . TYR A 1 249 ? 9.566   17.177  17.328  1.000 9.199  0 249 TYR A N   1 ? 
ATOM   1954 C  CA  . TYR A 1 249 ? 9.837   15.810  16.885  1.000 8.642  0 249 TYR A CA  1 ? 
ATOM   1955 C  C   . TYR A 1 249 ? 9.301   14.809  17.926  1.000 8.507  0 249 TYR A C   1 ? 
ATOM   1956 O  O   . TYR A 1 249 ? 8.613   13.831  17.605  1.000 8.547  0 249 TYR A O   1 ? 
ATOM   1957 C  CB  . TYR A 1 249 ? 11.351  15.622  16.650  1.000 8.299  0 249 TYR A CB  1 ? 
ATOM   1958 C  CG  . TYR A 1 249 ? 11.750  14.189  16.384  1.000 8.478  0 249 TYR A CG  1 ? 
ATOM   1959 C  CD1 . TYR A 1 249 ? 11.393  13.548  15.203  1.000 8.930  0 249 TYR A CD1 1 ? 
ATOM   1960 C  CD2 . TYR A 1 249 ? 12.465  13.458  17.327  1.000 8.763  0 249 TYR A CD2 1 ? 
ATOM   1961 C  CE1 . TYR A 1 249 ? 11.739  12.231  14.977  1.000 9.263  0 249 TYR A CE1 1 ? 
ATOM   1962 C  CE2 . TYR A 1 249 ? 12.841  12.154  17.093  1.000 8.778  0 249 TYR A CE2 1 ? 
ATOM   1963 C  CZ  . TYR A 1 249 ? 12.458  11.542  15.935  1.000 9.549  0 249 TYR A CZ  1 ? 
ATOM   1964 O  OH  . TYR A 1 249 ? 12.815  10.238  15.710  1.000 11.676 0 249 TYR A OH  1 ? 
ATOM   1965 N  N   . PHE A 1 250 ? 9.688   15.047  19.184  1.000 7.722  0 250 PHE A N   1 ? 
ATOM   1966 C  CA  . PHE A 1 250 ? 9.234   14.160  20.264  1.000 8.131  0 250 PHE A CA  1 ? 
ATOM   1967 C  C   . PHE A 1 250 ? 7.725   14.231  20.486  1.000 8.202  0 250 PHE A C   1 ? 
ATOM   1968 O  O   . PHE A 1 250 ? 7.107   13.200  20.778  1.000 8.461  0 250 PHE A O   1 ? 
ATOM   1969 C  CB  . PHE A 1 250 ? 9.993   14.412  21.563  1.000 8.390  0 250 PHE A CB  1 ? 
ATOM   1970 C  CG  . PHE A 1 250 ? 11.398  13.857  21.474  1.000 9.490  0 250 PHE A CG  1 ? 
ATOM   1971 C  CD1 . PHE A 1 250 ? 11.598  12.484  21.366  1.000 10.115 0 250 PHE A CD1 1 ? 
ATOM   1972 C  CD2 . PHE A 1 250 ? 12.512  14.673  21.463  1.000 11.072 0 250 PHE A CD2 1 ? 
ATOM   1973 C  CE1 . PHE A 1 250 ? 12.892  11.978  21.280  1.000 10.501 0 250 PHE A CE1 1 ? 
ATOM   1974 C  CE2 . PHE A 1 250 ? 13.797  14.151  21.345  1.000 11.927 0 250 PHE A CE2 1 ? 
ATOM   1975 C  CZ  . PHE A 1 250 ? 13.950  12.802  21.229  1.000 11.477 0 250 PHE A CZ  1 ? 
ATOM   1976 N  N   . ALA A 1 251 ? 7.120   15.418  20.326  1.000 8.174  0 251 ALA A N   1 ? 
ATOM   1977 C  CA  . ALA A 1 251 ? 5.679   15.492  20.468  1.000 8.618  0 251 ALA A CA  1 ? 
ATOM   1978 C  C   . ALA A 1 251 ? 5.006   14.580  19.450  1.000 9.072  0 251 ALA A C   1 ? 
ATOM   1979 O  O   . ALA A 1 251 ? 4.016   13.894  19.750  1.000 9.507  0 251 ALA A O   1 ? 
ATOM   1980 C  CB  . ALA A 1 251 ? 5.242   16.945  20.303  1.000 9.457  0 251 ALA A CB  1 ? 
ATOM   1981 N  N   . GLU A 1 252 ? 5.507   14.571  18.191  1.000 9.208  0 252 GLU A N   1 ? 
ATOM   1982 C  CA  . GLU A 1 252 ? 4.939   13.726  17.153  1.000 10.834 0 252 GLU A CA  1 ? 
ATOM   1983 C  C   . GLU A 1 252 ? 5.147   12.243  17.467  1.000 10.853 0 252 GLU A C   1 ? 
ATOM   1984 O  O   . GLU A 1 252 ? 4.277   11.432  17.235  1.000 10.581 0 252 GLU A O   1 ? 
ATOM   1985 C  CB  . GLU A 1 252 ? 5.591   14.053  15.822  1.000 13.775 0 252 GLU A CB  1 ? 
ATOM   1986 C  CG  . GLU A 1 252 ? 4.999   13.188  14.707  1.000 16.869 0 252 GLU A CG  1 ? 
ATOM   1987 C  CD  . GLU A 1 252 ? 5.318   13.699  13.317  1.000 20.818 0 252 GLU A CD  1 ? 
ATOM   1988 O  OE1 . GLU A 1 252 ? 6.474   14.066  13.113  1.000 20.540 0 252 GLU A OE1 1 ? 
ATOM   1989 O  OE2 . GLU A 1 252 ? 4.405   13.779  12.479  1.000 22.735 0 252 GLU A OE2 1 ? 
ATOM   1990 N  N   . LYS A 1 253 ? 6.320   11.888  17.966  1.000 10.035 0 253 LYS A N   1 ? 
ATOM   1991 C  CA  . LYS A 1 253 ? 6.526   10.504  18.356  1.000 10.704 0 253 LYS A CA  1 ? 
ATOM   1992 C  C   . LYS A 1 253 ? 5.516   10.077  19.436  1.000 10.323 0 253 LYS A C   1 ? 
ATOM   1993 O  O   . LYS A 1 253 ? 4.994   8.973   19.422  1.000 10.359 0 253 LYS A O   1 ? 
ATOM   1994 C  CB  . LYS A 1 253 ? 7.945   10.212  18.860  1.000 10.501 0 253 LYS A CB  1 ? 
ATOM   1995 C  CG  . LYS A 1 253 ? 9.035   10.365  17.741  1.000 13.706 0 253 LYS A CG  1 ? 
ATOM   1996 C  CD  . LYS A 1 253 ? 10.050  9.224   17.740  1.000 15.242 0 253 LYS A CD  1 ? 
ATOM   1997 C  CE  . LYS A 1 253 ? 9.459   7.917   17.289  1.000 15.563 0 253 LYS A CE  1 ? 
ATOM   1998 N  NZ  . LYS A 1 253 ? 10.465  6.855   17.445  1.000 15.633 0 253 LYS A NZ  1 ? 
ATOM   1999 N  N   . LEU A 1 254 ? 5.243   10.954  20.418  1.000 9.965  0 254 LEU A N   1 ? 
ATOM   2000 C  CA  . LEU A 1 254 ? 4.292   10.616  21.461  1.000 8.458  0 254 LEU A CA  1 ? 
ATOM   2001 C  C   . LEU A 1 254 ? 2.869   10.488  20.897  1.000 8.574  0 254 LEU A C   1 ? 
ATOM   2002 O  O   . LEU A 1 254 ? 2.164   9.521   21.223  1.000 8.535  0 254 LEU A O   1 ? 
ATOM   2003 C  CB  . LEU A 1 254 ? 4.349   11.680  22.542  1.000 8.442  0 254 LEU A CB  1 ? 
ATOM   2004 C  CG  . LEU A 1 254 ? 5.606   11.641  23.422  1.000 8.502  0 254 LEU A CG  1 ? 
ATOM   2005 C  CD1 . LEU A 1 254 ? 5.776   12.913  24.181  1.000 9.773  0 254 LEU A CD1 1 ? 
ATOM   2006 C  CD2 . LEU A 1 254 ? 5.570   10.469  24.402  1.000 9.195  0 254 LEU A CD2 1 ? 
ATOM   2007 N  N   . TYR A 1 255 ? 2.485   11.399  20.003  1.000 9.015  0 255 TYR A N   1 ? 
ATOM   2008 C  CA  . TYR A 1 255 ? 1.176   11.303  19.353  1.000 9.759  0 255 TYR A CA  1 ? 
ATOM   2009 C  C   . TYR A 1 255 ? 1.022   9.961   18.645  1.000 9.930  0 255 TYR A C   1 ? 
ATOM   2010 O  O   . TYR A 1 255 ? 0.023   9.252   18.875  1.000 10.976 0 255 TYR A O   1 ? 
ATOM   2011 C  CB  . TYR A 1 255 ? 1.051   12.476  18.388  1.000 10.516 0 255 TYR A CB  1 ? 
ATOM   2012 C  CG  . TYR A 1 255 ? -0.224  12.470  17.566  1.000 12.218 0 255 TYR A CG  1 ? 
ATOM   2013 C  CD1 . TYR A 1 255 ? -1.426  12.867  18.113  1.000 12.574 0 255 TYR A CD1 1 ? 
ATOM   2014 C  CD2 . TYR A 1 255 ? -0.222  11.988  16.282  1.000 12.829 0 255 TYR A CD2 1 ? 
ATOM   2015 C  CE1 . TYR A 1 255 ? -2.609  12.883  17.370  1.000 14.868 0 255 TYR A CE1 1 ? 
ATOM   2016 C  CE2 . TYR A 1 255 ? -1.396  11.979  15.529  1.000 14.941 0 255 TYR A CE2 1 ? 
ATOM   2017 C  CZ  . TYR A 1 255 ? -2.573  12.446  16.073  1.000 15.409 0 255 TYR A CZ  1 ? 
ATOM   2018 O  OH  . TYR A 1 255 ? -3.771  12.449  15.355  1.000 19.350 0 255 TYR A OH  1 ? 
ATOM   2019 N  N   . LYS A 1 256 ? 2.024   9.620   17.846  1.000 10.107 0 256 LYS A N   1 ? 
ATOM   2020 C  CA  . LYS A 1 256 ? 1.947   8.385   17.063  1.000 10.269 0 256 LYS A CA  1 ? 
ATOM   2021 C  C   . LYS A 1 256 ? 1.924   7.155   17.961  1.000 9.867  0 256 LYS A C   1 ? 
ATOM   2022 O  O   . LYS A 1 256 ? 1.369   6.123   17.565  1.000 11.383 0 256 LYS A O   1 ? 
ATOM   2023 C  CB  . LYS A 1 256 ? 3.042   8.372   15.994  1.000 11.025 0 256 LYS A CB  1 ? 
ATOM   2024 C  CG  . LYS A 1 256 ? 2.841   9.367   14.899  1.000 14.194 0 256 LYS A CG  1 ? 
ATOM   2025 C  CD  . LYS A 1 256 ? 3.887   9.288   13.795  1.000 18.406 0 256 LYS A CD  1 ? 
ATOM   2026 C  CE  . LYS A 1 256 ? 3.496   10.229  12.719  1.000 24.423 0 256 LYS A CE  1 ? 
ATOM   2027 N  NZ  . LYS A 1 256 ? 4.521   10.138  11.669  1.000 30.742 0 256 LYS A NZ  1 ? 
ATOM   2028 N  N   . SER A 1 257 ? 2.586   7.209   19.119  1.000 9.292  0 257 SER A N   1 ? 
ATOM   2029 C  CA  . SER A 1 257 ? 2.621   6.057   19.997  1.000 9.759  0 257 SER A CA  1 ? 
ATOM   2030 C  C   . SER A 1 257 ? 1.260   5.754   20.598  1.000 10.063 0 257 SER A C   1 ? 
ATOM   2031 O  O   . SER A 1 257 ? 1.068   4.651   21.098  1.000 11.167 0 257 SER A O   1 ? 
ATOM   2032 C  CB  . SER A 1 257 ? 3.641   6.237   21.108  1.000 9.820  0 257 SER A CB  1 ? 
ATOM   2033 O  OG  . SER A 1 257 ? 3.239   7.153   22.148  1.000 10.088 0 257 SER A OG  1 ? 
ATOM   2034 N  N   . MET A 1 258 ? 0.389   6.766   20.676  1.000 10.062 0 258 MET A N   1 ? 
ATOM   2035 C  CA  . MET A 1 258 ? -0.883  6.633   21.396  1.000 10.801 0 258 MET A CA  1 ? 
ATOM   2036 C  C   . MET A 1 258 ? -2.114  6.735   20.483  1.000 11.449 0 258 MET A C   1 ? 
ATOM   2037 O  O   . MET A 1 258 ? -3.162  6.219   20.861  1.000 13.780 0 258 MET A O   1 ? 
ATOM   2038 C  CB  . MET A 1 258 ? -1.002  7.654   22.541  1.000 10.662 0 258 MET A CB  1 ? 
ATOM   2039 C  CG  . MET A 1 258 ? -0.067  7.348   23.696  1.000 9.836  0 258 MET A CG  1 ? 
ATOM   2040 S  SD  . MET A 1 258 ? -0.120  8.603   24.992  1.000 10.522 0 258 MET A SD  1 ? 
ATOM   2041 C  CE  . MET A 1 258 ? 0.963   9.829   24.238  1.000 11.895 0 258 MET A CE  1 ? 
ATOM   2042 N  N   . LYS A 1 259 ? -2.049  7.404   19.350  1.000 13.189 0 259 LYS A N   1 ? 
ATOM   2043 C  CA  . LYS A 1 259 ? -3.257  7.663   18.554  1.000 16.111 0 259 LYS A CA  1 ? 
ATOM   2044 C  C   . LYS A 1 259 ? -3.769  6.337   17.995  1.000 18.856 0 259 LYS A C   1 ? 
ATOM   2045 O  O   . LYS A 1 259 ? -3.021  5.415   17.736  1.000 22.961 0 259 LYS A O   1 ? 
ATOM   2046 C  CB  . LYS A 1 259 ? -2.869  8.685   17.479  1.000 18.739 0 259 LYS A CB  1 ? 
ATOM   2047 C  CG  . LYS A 1 259 ? -4.024  9.152   16.571  1.000 26.914 0 259 LYS A CG  1 ? 
ATOM   2048 C  CD  . LYS A 1 259 ? -5.100  9.778   17.449  1.000 31.859 0 259 LYS A CD  1 ? 
ATOM   2049 C  CE  . LYS A 1 259 ? -6.096  10.609  16.708  1.000 35.016 0 259 LYS A CE  1 ? 
ATOM   2050 N  NZ  . LYS A 1 259 ? -6.370  11.774  17.546  1.000 37.568 0 259 LYS A NZ  1 ? 
ATOM   2051 N  N   . GLY A 1 260 ? -5.088  6.199   17.872  1.000 20.586 0 260 GLY A N   1 ? 
ATOM   2052 C  CA  . GLY A 1 260 ? -5.623  4.911   17.414  1.000 26.978 0 260 GLY A CA  1 ? 
ATOM   2053 C  C   . GLY A 1 260 ? -5.238  3.672   18.257  1.000 27.622 0 260 GLY A C   1 ? 
ATOM   2054 O  O   . GLY A 1 260 ? -4.809  3.761   19.402  1.000 27.366 0 260 GLY A O   1 ? 
ATOM   2055 N  N   . LEU A 1 261 ? -5.458  2.473   17.691  1.000 28.976 0 261 LEU A N   1 ? 
ATOM   2056 C  CA  . LEU A 1 261 ? -5.765  1.301   18.492  1.000 32.446 0 261 LEU A CA  1 ? 
ATOM   2057 C  C   . LEU A 1 261 ? -4.542  0.857   19.289  1.000 29.719 0 261 LEU A C   1 ? 
ATOM   2058 O  O   . LEU A 1 261 ? -3.498  0.568   18.735  1.000 31.901 0 261 LEU A O   1 ? 
ATOM   2059 C  CB  . LEU A 1 261 ? -6.356  0.181   17.620  1.000 42.481 0 261 LEU A CB  1 ? 
ATOM   2060 C  CG  . LEU A 1 261 ? -5.485  -0.461  16.523  1.000 48.741 0 261 LEU A CG  1 ? 
ATOM   2061 C  CD1 . LEU A 1 261 ? -4.773  -1.727  16.985  1.000 52.915 0 261 LEU A CD1 1 ? 
ATOM   2062 C  CD2 . LEU A 1 261 ? -6.298  -0.803  15.264  1.000 51.030 0 261 LEU A CD2 1 ? 
ATOM   2063 N  N   . GLY A 1 262 ? -4.681  0.782   20.607  1.000 28.791 0 262 GLY A N   1 ? 
ATOM   2064 C  CA  . GLY A 1 262 ? -3.590  0.276   21.433  1.000 26.475 0 262 GLY A CA  1 ? 
ATOM   2065 C  C   . GLY A 1 262 ? -2.478  1.314   21.592  1.000 24.110 0 262 GLY A C   1 ? 
ATOM   2066 O  O   . GLY A 1 262 ? -2.710  2.527   21.466  1.000 25.475 0 262 GLY A O   1 ? 
ATOM   2067 N  N   . THR A 1 263 ? -1.280  0.847   21.953  1.000 16.454 0 263 THR A N   1 ? 
ATOM   2068 C  CA  . THR A 1 263 ? -0.256  1.792   22.377  1.000 15.260 0 263 THR A CA  1 ? 
ATOM   2069 C  C   . THR A 1 263 ? 1.103   1.188   22.070  1.000 13.097 0 263 THR A C   1 ? 
ATOM   2070 O  O   . THR A 1 263 ? 1.371   0.045   22.436  1.000 13.864 0 263 THR A O   1 ? 
ATOM   2071 C  CB  . THR A 1 263 ? -0.348  2.071   23.875  1.000 16.065 0 263 THR A CB  1 ? 
ATOM   2072 O  OG1 . THR A 1 263 ? -1.640  2.570   24.237  1.000 20.682 0 263 THR A OG1 1 ? 
ATOM   2073 C  CG2 . THR A 1 263 ? 0.683   3.097   24.294  1.000 14.915 0 263 THR A CG2 1 ? 
ATOM   2074 N  N   . ASP A 1 264 ? 1.996   2.005   21.495  1.000 11.293 0 264 ASP A N   1 ? 
ATOM   2075 C  CA  . ASP A 1 264 ? 3.390   1.620   21.403  1.000 10.656 0 264 ASP A CA  1 ? 
ATOM   2076 C  C   . ASP A 1 264 ? 4.089   1.973   22.721  1.000 10.005 0 264 ASP A C   1 ? 
ATOM   2077 O  O   . ASP A 1 264 ? 4.703   3.038   22.873  1.000 10.712 0 264 ASP A O   1 ? 
ATOM   2078 C  CB  . ASP A 1 264 ? 4.038   2.303   20.224  1.000 10.005 0 264 ASP A CB  1 ? 
ATOM   2079 C  CG  . ASP A 1 264 ? 5.514   2.002   20.025  1.000 10.038 0 264 ASP A CG  1 ? 
ATOM   2080 O  OD1 . ASP A 1 264 ? 6.073   1.229   20.825  1.000 12.055 0 264 ASP A OD1 1 ? 
ATOM   2081 O  OD2 . ASP A 1 264 ? 6.099   2.576   19.103  1.000 11.108 0 264 ASP A OD2 1 ? 
ATOM   2082 N  N   . ASP A 1 265 ? 4.021   1.080   23.695  1.000 10.275 0 265 ASP A N   1 ? 
ATOM   2083 C  CA  . ASP A 1 265 ? 4.501   1.381   25.033  1.000 10.349 0 265 ASP A CA  1 ? 
ATOM   2084 C  C   . ASP A 1 265 ? 6.018   1.562   25.063  1.000 10.504 0 265 ASP A C   1 ? 
ATOM   2085 O  O   . ASP A 1 265 ? 6.555   2.396   25.770  1.000 9.597  0 265 ASP A O   1 ? 
ATOM   2086 C  CB  . ASP A 1 265 ? 4.094   0.311   26.028  1.000 11.279 0 265 ASP A CB  1 ? 
ATOM   2087 C  CG  . ASP A 1 265 ? 2.598   0.223   26.266  1.000 12.763 0 265 ASP A CG  1 ? 
ATOM   2088 O  OD1 . ASP A 1 265 ? 2.012   1.181   26.749  1.000 13.987 0 265 ASP A OD1 1 ? 
ATOM   2089 O  OD2 . ASP A 1 265 ? 2.034   -0.822  25.864  1.000 18.729 0 265 ASP A OD2 1 ? 
ATOM   2090 N  N   . ASN A 1 266 ? 6.758   0.822   24.250  1.000 9.982  0 266 ASN A N   1 ? 
ATOM   2091 C  CA  . ASN A 1 266 ? 8.203   0.948   24.260  1.000 10.203 0 266 ASN A CA  1 ? 
ATOM   2092 C  C   . ASN A 1 266 ? 8.625   2.369   23.879  1.000 9.620  0 266 ASN A C   1 ? 
ATOM   2093 O  O   . ASN A 1 266 ? 9.543   2.956   24.477  1.000 9.618  0 266 ASN A O   1 ? 
ATOM   2094 C  CB  . ASN A 1 266 ? 8.868   -0.071  23.351  1.000 11.521 0 266 ASN A CB  1 ? 
ATOM   2095 C  CG  . ASN A 1 266 ? 8.890   -1.466  23.913  1.000 16.640 0 266 ASN A CG  1 ? 
ATOM   2096 O  OD1 . ASN A 1 266 ? 8.685   -2.467  23.188  1.000 23.252 0 266 ASN A OD1 1 ? 
ATOM   2097 N  ND2 . ASN A 1 266 ? 9.158   -1.593  25.177  1.000 12.567 0 266 ASN A ND2 1 ? 
ATOM   2098 N  N   . THR A 1 267 ? 7.978   2.950   22.862  1.000 8.578  0 267 THR A N   1 ? 
ATOM   2099 C  CA  . THR A 1 267 ? 8.286   4.312   22.433  1.000 8.430  0 267 THR A CA  1 ? 
ATOM   2100 C  C   . THR A 1 267 ? 7.796   5.321   23.476  1.000 7.329  0 267 THR A C   1 ? 
ATOM   2101 O  O   . THR A 1 267 ? 8.529   6.268   23.818  1.000 7.965  0 267 THR A O   1 ? 
ATOM   2102 C  CB  . THR A 1 267 ? 7.745   4.630   21.035  1.000 9.126  0 267 THR A CB  1 ? 
ATOM   2103 O  OG1 . THR A 1 267 ? 8.333   3.731   20.090  1.000 8.737  0 267 THR A OG1 1 ? 
ATOM   2104 C  CG2 . THR A 1 267 ? 7.970   6.069   20.617  1.000 8.533  0 267 THR A CG2 1 ? 
ATOM   2105 N  N   . LEU A 1 268 ? 6.535   5.184   23.926  1.000 8.278  0 268 LEU A N   1 ? 
ATOM   2106 C  CA  . LEU A 1 268 ? 5.989   6.114   24.923  1.000 8.105  0 268 LEU A CA  1 ? 
ATOM   2107 C  C   . LEU A 1 268 ? 6.895   6.180   26.152  1.000 7.769  0 268 LEU A C   1 ? 
ATOM   2108 O  O   . LEU A 1 268 ? 7.243   7.260   26.635  1.000 7.777  0 268 LEU A O   1 ? 
ATOM   2109 C  CB  . LEU A 1 268 ? 4.582   5.624   25.277  1.000 9.064  0 268 LEU A CB  1 ? 
ATOM   2110 C  CG  . LEU A 1 268 ? 3.857   6.341   26.412  1.000 9.299  0 268 LEU A CG  1 ? 
ATOM   2111 C  CD1 . LEU A 1 268 ? 3.762   7.806   26.133  1.000 9.535  0 268 LEU A CD1 1 ? 
ATOM   2112 C  CD2 . LEU A 1 268 ? 2.485   5.727   26.681  1.000 9.745  0 268 LEU A CD2 1 ? 
ATOM   2113 N  N   . ILE A 1 269 ? 7.293   5.003   26.659  1.000 8.009  0 269 ILE A N   1 ? 
ATOM   2114 C  CA  . ILE A 1 269 ? 8.149   4.921   27.836  1.000 8.468  0 269 ILE A CA  1 ? 
ATOM   2115 C  C   . ILE A 1 269 ? 9.498   5.601   27.573  1.000 7.457  0 269 ILE A C   1 ? 
ATOM   2116 O  O   . ILE A 1 269 ? 9.943   6.448   28.356  1.000 7.834  0 269 ILE A O   1 ? 
ATOM   2117 C  CB  . ILE A 1 269 ? 8.297   3.472   28.338  1.000 8.921  0 269 ILE A CB  1 ? 
ATOM   2118 C  CG1 . ILE A 1 269 ? 6.988   2.960   28.842  1.000 9.950  0 269 ILE A CG1 1 ? 
ATOM   2119 C  CG2 . ILE A 1 269 ? 9.418   3.348   29.358  1.000 8.631  0 269 ILE A CG2 1 ? 
ATOM   2120 C  CD1 . ILE A 1 269 ? 6.957   1.479   29.093  1.000 9.711  0 269 ILE A CD1 1 ? 
ATOM   2121 N  N   . ARG A 1 270 ? 10.176  5.230   26.471  1.000 7.517  0 270 ARG A N   1 ? 
ATOM   2122 C  CA  . ARG A 1 270 ? 11.526  5.725   26.227  1.000 7.674  0 270 ARG A CA  1 ? 
ATOM   2123 C  C   . ARG A 1 270 ? 11.497  7.238   26.074  1.000 8.180  0 270 ARG A C   1 ? 
ATOM   2124 O  O   . ARG A 1 270 ? 12.368  7.927   26.607  1.000 7.804  0 270 ARG A O   1 ? 
ATOM   2125 C  CB  . ARG A 1 270 ? 12.089  5.094   24.954  1.000 7.788  0 270 ARG A CB  1 ? 
ATOM   2126 C  CG  . ARG A 1 270 ? 13.480  5.592   24.595  1.000 9.058  0 270 ARG A CG  1 ? 
ATOM   2127 C  CD  . ARG A 1 270 ? 14.117  4.916   23.393  1.000 10.317 0 270 ARG A CD  1 ? 
ATOM   2128 N  NE  . ARG A 1 270 ? 13.257  5.005   22.207  1.000 10.271 0 270 ARG A NE  1 ? 
ATOM   2129 C  CZ  . ARG A 1 270 ? 12.493  4.068   21.707  1.000 10.395 0 270 ARG A CZ  1 ? 
ATOM   2130 N  NH1 . ARG A 1 270 ? 12.567  2.866   22.179  1.000 10.815 0 270 ARG A NH1 1 ? 
ATOM   2131 N  NH2 . ARG A 1 270 ? 11.659  4.316   20.712  1.000 11.218 0 270 ARG A NH2 1 ? 
ATOM   2132 N  N   . VAL A 1 271 ? 10.512  7.799   25.357  1.000 7.377  0 271 VAL A N   1 ? 
ATOM   2133 C  CA  . VAL A 1 271 ? 10.454  9.241   25.188  1.000 7.266  0 271 VAL A CA  1 ? 
ATOM   2134 C  C   . VAL A 1 271 ? 10.177  9.947   26.516  1.000 7.431  0 271 VAL A C   1 ? 
ATOM   2135 O  O   . VAL A 1 271 ? 10.842  10.889  26.872  1.000 7.937  0 271 VAL A O   1 ? 
ATOM   2136 C  CB  . VAL A 1 271 ? 9.433   9.669   24.118  1.000 7.981  0 271 VAL A CB  1 ? 
ATOM   2137 C  CG1 . VAL A 1 271 ? 9.257   11.180  24.102  1.000 8.823  0 271 VAL A CG1 1 ? 
ATOM   2138 C  CG2 . VAL A 1 271 ? 9.817   9.165   22.736  1.000 8.853  0 271 VAL A CG2 1 ? 
ATOM   2139 N  N   . MET A 1 272 ? 9.204   9.445   27.303  1.000 7.689  0 272 MET A N   1 ? 
ATOM   2140 C  CA  . MET A 1 272 ? 8.888   10.092  28.580  1.000 8.118  0 272 MET A CA  1 ? 
ATOM   2141 C  C   . MET A 1 272 ? 10.061  10.038  29.555  1.000 8.672  0 272 MET A C   1 ? 
ATOM   2142 O  O   . MET A 1 272 ? 10.389  11.038  30.212  1.000 9.308  0 272 MET A O   1 ? 
ATOM   2143 C  CB  . MET A 1 272 ? 7.624   9.519   29.218  1.000 8.742  0 272 MET A CB  1 ? 
ATOM   2144 C  CG  . MET A 1 272 ? 6.349   9.750   28.417  1.000 9.690  0 272 MET A CG  1 ? 
ATOM   2145 S  SD  . MET A 1 272 ? 5.968   11.470  28.033  1.000 8.855  0 272 MET A SD  1 ? 
ATOM   2146 C  CE  . MET A 1 272 ? 5.809   12.167  29.691  1.000 9.618  0 272 MET A CE  1 ? 
ATOM   2147 N  N   . VAL A 1 273 ? 10.728  8.891   29.659  1.000 8.281  0 273 VAL A N   1 ? 
ATOM   2148 C  CA  . VAL A 1 273 ? 11.871  8.737   30.555  1.000 9.549  0 273 VAL A CA  1 ? 
ATOM   2149 C  C   . VAL A 1 273 ? 13.023  9.604   30.071  1.000 9.840  0 273 VAL A C   1 ? 
ATOM   2150 O  O   . VAL A 1 273 ? 13.627  10.352  30.856  1.000 11.260 0 273 VAL A O   1 ? 
ATOM   2151 C  CB  . VAL A 1 273 ? 12.295  7.258   30.658  1.000 8.984  0 273 VAL A CB  1 ? 
ATOM   2152 C  CG1 . VAL A 1 273 ? 13.632  7.127   31.361  1.000 9.988  0 273 VAL A CG1 1 ? 
ATOM   2153 C  CG2 . VAL A 1 273 ? 11.218  6.474   31.382  1.000 9.470  0 273 VAL A CG2 1 ? 
ATOM   2154 N  N   . SER A 1 274 ? 13.358  9.571   28.776  1.000 8.937  0 274 SER A N   1 ? 
ATOM   2155 C  CA  . SER A 1 274 ? 14.544  10.212  28.262  1.000 9.528  0 274 SER A CA  1 ? 
ATOM   2156 C  C   . SER A 1 274 ? 14.398  11.720  28.209  1.000 10.773 0 274 SER A C   1 ? 
ATOM   2157 O  O   . SER A 1 274 ? 15.418  12.403  28.241  1.000 12.497 0 274 SER A O   1 ? 
ATOM   2158 C  CB  . SER A 1 274 ? 14.967  9.630   26.912  1.000 10.540 0 274 SER A CB  1 ? 
ATOM   2159 O  OG  . SER A 1 274 ? 14.009  9.898   25.920  1.000 11.841 0 274 SER A OG  1 ? 
ATOM   2160 N  N   . ARG A 1 275 ? 13.179  12.273  28.080  1.000 9.503  0 275 ARG A N   1 ? 
ATOM   2161 C  CA  . ARG A 1 275 ? 13.013  13.701  27.843  1.000 9.690  0 275 ARG A CA  1 ? 
ATOM   2162 C  C   . ARG A 1 275 ? 12.451  14.463  29.033  1.000 8.886  0 275 ARG A C   1 ? 
ATOM   2163 O  O   . ARG A 1 275 ? 12.432  15.695  29.026  1.000 9.286  0 275 ARG A O   1 ? 
ATOM   2164 C  CB  . ARG A 1 275 ? 12.117  13.951  26.614  1.000 9.794  0 275 ARG A CB  1 ? 
ATOM   2165 C  CG  . ARG A 1 275 ? 12.654  13.328  25.328  1.000 9.837  0 275 ARG A CG  1 ? 
ATOM   2166 C  CD  . ARG A 1 275 ? 14.092  13.604  24.981  1.000 11.365 0 275 ARG A CD  1 ? 
ATOM   2167 N  NE  . ARG A 1 275 ? 14.335  15.007  24.649  1.000 13.041 0 275 ARG A NE  1 ? 
ATOM   2168 C  CZ  . ARG A 1 275 ? 15.423  15.462  24.026  1.000 15.763 0 275 ARG A CZ  1 ? 
ATOM   2169 N  NH1 . ARG A 1 275 ? 16.445  14.654  23.892  1.000 17.334 0 275 ARG A NH1 1 ? 
ATOM   2170 N  NH2 . ARG A 1 275 ? 15.421  16.707  23.573  1.000 16.728 0 275 ARG A NH2 1 ? 
ATOM   2171 N  N   . ALA A 1 276 ? 12.049  13.735  30.105  1.000 8.787  0 276 ALA A N   1 ? 
ATOM   2172 C  CA  . ALA A 1 276 ? 11.403  14.381  31.261  1.000 9.065  0 276 ALA A CA  1 ? 
ATOM   2173 C  C   . ALA A 1 276 ? 12.228  15.533  31.824  1.000 11.126 0 276 ALA A C   1 ? 
ATOM   2174 O  O   . ALA A 1 276 ? 11.681  16.549  32.256  1.000 11.379 0 276 ALA A O   1 ? 
ATOM   2175 C  CB  . ALA A 1 276 ? 11.119  13.389  32.349  1.000 9.745  0 276 ALA A CB  1 ? 
ATOM   2176 N  N   . GLU A 1 277 ? 13.548  15.375  31.881  1.000 10.637 0 277 GLU A N   1 ? 
ATOM   2177 C  CA  . GLU A 1 277 ? 14.412  16.391  32.479  1.000 11.500 0 277 GLU A CA  1 ? 
ATOM   2178 C  C   . GLU A 1 277 ? 14.962  17.390  31.488  1.000 14.545 0 277 GLU A C   1 ? 
ATOM   2179 O  O   . GLU A 1 277 ? 15.630  18.357  31.883  1.000 17.984 0 277 GLU A O   1 ? 
ATOM   2180 C  CB  . GLU A 1 277 ? 15.690  15.770  33.046  1.000 14.673 0 277 GLU A CB  1 ? 
ATOM   2181 C  CG  . GLU A 1 277 ? 15.385  14.983  34.290  1.000 13.741 0 277 GLU A CG  1 ? 
ATOM   2182 C  CD  . GLU A 1 277 ? 16.570  14.306  34.970  1.000 15.856 0 277 GLU A CD  1 ? 
ATOM   2183 O  OE1 . GLU A 1 277 ? 17.657  14.935  34.995  1.000 18.620 0 277 GLU A OE1 1 ? 
ATOM   2184 O  OE2 . GLU A 1 277 ? 16.363  13.211  35.433  1.000 14.797 0 277 GLU A OE2 1 ? 
ATOM   2185 N  N   . ILE A 1 278 ? 14.757  17.164  30.193  1.000 11.905 0 278 ILE A N   1 ? 
ATOM   2186 C  CA  . ILE A 1 278 ? 15.368  17.961  29.139  1.000 13.403 0 278 ILE A CA  1 ? 
ATOM   2187 C  C   . ILE A 1 278 ? 14.392  19.023  28.666  1.000 12.933 0 278 ILE A C   1 ? 
ATOM   2188 O  O   . ILE A 1 278 ? 14.658  20.241  28.760  1.000 14.547 0 278 ILE A O   1 ? 
ATOM   2189 C  CB  . ILE A 1 278 ? 15.873  17.059  27.996  1.000 14.658 0 278 ILE A CB  1 ? 
ATOM   2190 C  CG1 . ILE A 1 278 ? 16.820  16.048  28.591  1.000 16.672 0 278 ILE A CG1 1 ? 
ATOM   2191 C  CG2 . ILE A 1 278 ? 16.525  17.892  26.917  1.000 15.521 0 278 ILE A CG2 1 ? 
ATOM   2192 C  CD1 . ILE A 1 278 ? 17.527  15.160  27.608  1.000 17.826 0 278 ILE A CD1 1 ? 
ATOM   2193 N  N   . ASP A 1 279 ? 13.293  18.577  28.035  1.000 10.898 0 279 ASP A N   1 ? 
ATOM   2194 C  CA  . ASP A 1 279 ? 12.457  19.494  27.298  1.000 10.879 0 279 ASP A CA  1 ? 
ATOM   2195 C  C   . ASP A 1 279 ? 10.975  19.110  27.343  1.000 9.484  0 279 ASP A C   1 ? 
ATOM   2196 O  O   . ASP A 1 279 ? 10.234  19.538  26.472  1.000 10.611 0 279 ASP A O   1 ? 
ATOM   2197 C  CB  . ASP A 1 279 ? 12.930  19.615  25.865  1.000 11.056 0 279 ASP A CB  1 ? 
ATOM   2198 C  CG  . ASP A 1 279 ? 12.876  18.313  25.073  1.000 12.421 0 279 ASP A CG  1 ? 
ATOM   2199 O  OD1 . ASP A 1 279 ? 12.795  17.225  25.698  1.000 12.552 0 279 ASP A OD1 1 ? 
ATOM   2200 O  OD2 . ASP A 1 279 ? 13.034  18.427  23.827  1.000 15.674 0 279 ASP A OD2 1 ? 
ATOM   2201 N  N   . MET A 1 280 ? 10.548  18.372  28.377  1.000 9.388  0 280 MET A N   1 ? 
ATOM   2202 C  CA  . MET A 1 280 ? 9.149   17.951  28.435  1.000 9.875  0 280 MET A CA  1 ? 
ATOM   2203 C  C   . MET A 1 280 ? 8.174   19.130  28.395  1.000 8.555  0 280 MET A C   1 ? 
ATOM   2204 O  O   . MET A 1 280 ? 7.086   19.012  27.837  1.000 9.368  0 280 MET A O   1 ? 
ATOM   2205 C  CB  . MET A 1 280 ? 8.911   17.106  29.692  1.000 9.395  0 280 MET A CB  1 ? 
ATOM   2206 C  CG  . MET A 1 280 ? 7.553   16.376  29.738  1.000 10.947 0 280 MET A CG  1 ? 
ATOM   2207 S  SD  . MET A 1 280 ? 7.187   15.342  28.312  1.000 10.638 0 280 MET A SD  1 ? 
ATOM   2208 C  CE  . MET A 1 280 ? 8.550   14.180  28.552  1.000 12.009 0 280 MET A CE  1 ? 
ATOM   2209 N  N   . LEU A 1 281 ? 8.510   20.281  29.007  1.000 9.947  0 281 LEU A N   1 ? 
ATOM   2210 C  CA  . LEU A 1 281 ? 7.581   21.396  28.929  1.000 10.517 0 281 LEU A CA  1 ? 
ATOM   2211 C  C   . LEU A 1 281 ? 7.441   21.914  27.517  1.000 10.306 0 281 LEU A C   1 ? 
ATOM   2212 O  O   . LEU A 1 281 ? 6.352   22.326  27.081  1.000 11.045 0 281 LEU A O   1 ? 
ATOM   2213 C  CB  . LEU A 1 281 ? 8.000   22.539  29.854  1.000 12.195 0 281 LEU A CB  1 ? 
ATOM   2214 C  CG  . LEU A 1 281 ? 7.970   22.220  31.345  1.000 14.108 0 281 LEU A CG  1 ? 
ATOM   2215 C  CD1 . LEU A 1 281 ? 8.420   23.432  32.145  1.000 17.669 0 281 LEU A CD1 1 ? 
ATOM   2216 C  CD2 . LEU A 1 281 ? 6.582   21.785  31.802  1.000 16.292 0 281 LEU A CD2 1 ? 
ATOM   2217 N  N   . ASP A 1 282 ? 8.557   21.900  26.781  1.000 11.045 0 282 ASP A N   1 ? 
ATOM   2218 C  CA  . ASP A 1 282 ? 8.515   22.303  25.384  1.000 10.952 0 282 ASP A CA  1 ? 
ATOM   2219 C  C   . ASP A 1 282 ? 7.733   21.287  24.535  1.000 10.238 0 282 ASP A C   1 ? 
ATOM   2220 O  O   . ASP A 1 282 ? 6.959   21.649  23.651  1.000 10.521 0 282 ASP A O   1 ? 
ATOM   2221 C  CB  . ASP A 1 282 ? 9.916   22.521  24.854  1.000 12.403 0 282 ASP A CB  1 ? 
ATOM   2222 C  CG  . ASP A 1 282 ? 10.691  23.542  25.652  1.000 16.775 0 282 ASP A CG  1 ? 
ATOM   2223 O  OD1 . ASP A 1 282 ? 10.241  24.706  25.594  1.000 20.160 0 282 ASP A OD1 1 ? 
ATOM   2224 O  OD2 . ASP A 1 282 ? 11.664  23.175  26.347  1.000 18.019 0 282 ASP A OD2 1 ? 
ATOM   2225 N  N   . ILE A 1 283 ? 7.939   19.982  24.806  1.000 10.068 0 283 ILE A N   1 ? 
ATOM   2226 C  CA  . ILE A 1 283 ? 7.191   18.917  24.150  1.000 9.887  0 283 ILE A CA  1 ? 
ATOM   2227 C  C   . ILE A 1 283 ? 5.696   19.138  24.333  1.000 10.569 0 283 ILE A C   1 ? 
ATOM   2228 O  O   . ILE A 1 283 ? 4.927   19.037  23.387  1.000 10.737 0 283 ILE A O   1 ? 
ATOM   2229 C  CB  . ILE A 1 283 ? 7.653   17.529  24.651  1.000 9.426  0 283 ILE A CB  1 ? 
ATOM   2230 C  CG1 . ILE A 1 283 ? 9.076   17.212  24.198  1.000 9.587  0 283 ILE A CG1 1 ? 
ATOM   2231 C  CG2 . ILE A 1 283 ? 6.715   16.440  24.156  1.000 9.568  0 283 ILE A CG2 1 ? 
ATOM   2232 C  CD1 . ILE A 1 283 ? 9.682   15.992  24.832  1.000 10.034 0 283 ILE A CD1 1 ? 
ATOM   2233 N  N   . ARG A 1 284 ? 5.301   19.407  25.585  1.000 9.607  0 284 ARG A N   1 ? 
ATOM   2234 C  CA  . ARG A 1 284 ? 3.882   19.639  25.877  1.000 10.219 0 284 ARG A CA  1 ? 
ATOM   2235 C  C   . ARG A 1 284 ? 3.321   20.788  25.064  1.000 10.943 0 284 ARG A C   1 ? 
ATOM   2236 O  O   . ARG A 1 284 ? 2.222   20.683  24.512  1.000 10.638 0 284 ARG A O   1 ? 
ATOM   2237 C  CB  . ARG A 1 284 ? 3.718   19.944  27.357  1.000 11.361 0 284 ARG A CB  1 ? 
ATOM   2238 C  CG  . ARG A 1 284 ? 3.708   18.676  28.181  1.000 11.661 0 284 ARG A CG  1 ? 
ATOM   2239 C  CD  . ARG A 1 284 ? 3.904   19.015  29.637  1.000 13.646 0 284 ARG A CD  1 ? 
ATOM   2240 N  NE  . ARG A 1 284 ? 2.732   19.721  30.177  1.000 15.811 0 284 ARG A NE  1 ? 
ATOM   2241 C  CZ  . ARG A 1 284 ? 2.669   20.267  31.409  1.000 20.439 0 284 ARG A CZ  1 ? 
ATOM   2242 N  NH1 . ARG A 1 284 ? 3.626   20.110  32.274  1.000 17.488 0 284 ARG A NH1 1 ? 
ATOM   2243 N  NH2 . ARG A 1 284 ? 1.554   20.847  31.783  1.000 24.835 0 284 ARG A NH2 1 ? 
ATOM   2244 N  N   . ALA A 1 285 ? 4.051   21.882  24.985  1.000 11.402 0 285 ALA A N   1 ? 
ATOM   2245 C  CA  . ALA A 1 285 ? 3.595   23.061  24.229  1.000 11.255 0 285 ALA A CA  1 ? 
ATOM   2246 C  C   . ALA A 1 285 ? 3.433   22.753  22.750  1.000 11.856 0 285 ALA A C   1 ? 
ATOM   2247 O  O   . ALA A 1 285 ? 2.438   23.115  22.107  1.000 12.891 0 285 ALA A O   1 ? 
ATOM   2248 C  CB  . ALA A 1 285 ? 4.544   24.218  24.469  1.000 13.301 0 285 ALA A CB  1 ? 
ATOM   2249 N  N   . HIS A 1 286 ? 4.456   22.087  22.170  1.000 11.433 0 286 HIS A N   1 ? 
ATOM   2250 C  CA  . HIS A 1 286 ? 4.368   21.730  20.772  1.000 11.408 0 286 HIS A CA  1 ? 
ATOM   2251 C  C   . HIS A 1 286 ? 3.266   20.721  20.504  1.000 11.337 0 286 HIS A C   1 ? 
ATOM   2252 O  O   . HIS A 1 286 ? 2.593   20.784  19.484  1.000 11.939 0 286 HIS A O   1 ? 
ATOM   2253 C  CB  . HIS A 1 286 ? 5.700   21.213  20.211  1.000 12.091 0 286 HIS A CB  1 ? 
ATOM   2254 C  CG  . HIS A 1 286 ? 6.697   22.303  20.053  1.000 12.807 0 286 HIS A CG  1 ? 
ATOM   2255 N  ND1 . HIS A 1 286 ? 6.800   23.020  18.879  1.000 15.449 0 286 HIS A ND1 1 ? 
ATOM   2256 C  CD2 . HIS A 1 286 ? 7.585   22.839  20.894  1.000 14.027 0 286 HIS A CD2 1 ? 
ATOM   2257 C  CE1 . HIS A 1 286 ? 7.760   23.934  19.027  1.000 16.213 0 286 HIS A CE1 1 ? 
ATOM   2258 N  NE2 . HIS A 1 286 ? 8.267   23.867  20.229  1.000 15.426 0 286 HIS A NE2 1 ? 
ATOM   2259 N  N   . PHE A 1 287 ? 3.051   19.752  21.412  1.000 10.104 0 287 PHE A N   1 ? 
ATOM   2260 C  CA  . PHE A 1 287 ? 1.994   18.771  21.249  1.000 10.461 0 287 PHE A CA  1 ? 
ATOM   2261 C  C   . PHE A 1 287 ? 0.639   19.459  21.146  1.000 11.618 0 287 PHE A C   1 ? 
ATOM   2262 O  O   . PHE A 1 287 ? -0.177  19.126  20.271  1.000 11.696 0 287 PHE A O   1 ? 
ATOM   2263 C  CB  . PHE A 1 287 ? 2.065   17.797  22.431  1.000 9.068  0 287 PHE A CB  1 ? 
ATOM   2264 C  CG  . PHE A 1 287 ? 1.145   16.603  22.290  1.000 9.210  0 287 PHE A CG  1 ? 
ATOM   2265 C  CD1 . PHE A 1 287 ? -0.210  16.716  22.581  1.000 9.550  0 287 PHE A CD1 1 ? 
ATOM   2266 C  CD2 . PHE A 1 287 ? 1.617   15.360  21.876  1.000 9.065  0 287 PHE A CD2 1 ? 
ATOM   2267 C  CE1 . PHE A 1 287 ? -1.045  15.653  22.432  1.000 10.471 0 287 PHE A CE1 1 ? 
ATOM   2268 C  CE2 . PHE A 1 287 ? 0.763   14.270  21.783  1.000 9.617  0 287 PHE A CE2 1 ? 
ATOM   2269 C  CZ  . PHE A 1 287 ? -0.593  14.433  22.029  1.000 10.130 0 287 PHE A CZ  1 ? 
ATOM   2270 N  N   . LYS A 1 288 ? 0.428   20.430  22.059  1.000 11.666 0 288 LYS A N   1 ? 
ATOM   2271 C  CA  . LYS A 1 288 ? -0.853  21.123  22.038  1.000 13.141 0 288 LYS A CA  1 ? 
ATOM   2272 C  C   . LYS A 1 288 ? -1.034  21.917  20.742  1.000 13.428 0 288 LYS A C   1 ? 
ATOM   2273 O  O   . LYS A 1 288 ? -2.121  21.898  20.115  1.000 14.096 0 288 LYS A O   1 ? 
ATOM   2274 C  CB  . LYS A 1 288 ? -0.896  22.122  23.195  1.000 15.190 0 288 LYS A CB  1 ? 
ATOM   2275 C  CG  . LYS A 1 288 ? -2.130  22.994  23.157  1.000 20.056 0 288 LYS A CG  1 ? 
ATOM   2276 C  CD  . LYS A 1 288 ? -2.458  23.583  24.522  1.000 31.105 0 288 LYS A CD  1 ? 
ATOM   2277 C  CE  . LYS A 1 288 ? -3.933  23.359  24.819  1.000 37.313 0 288 LYS A CE  1 ? 
ATOM   2278 N  NZ  . LYS A 1 288 ? -4.767  23.966  23.784  1.000 40.353 0 288 LYS A NZ  1 ? 
ATOM   2279 N  N   . ARG A 1 289 ? 0.011   22.567  20.276  1.000 12.601 0 289 ARG A N   1 ? 
ATOM   2280 C  CA  . ARG A 1 289 ? -0.073  23.317  19.016  1.000 15.544 0 289 ARG A CA  1 ? 
ATOM   2281 C  C   . ARG A 1 289 ? -0.361  22.400  17.829  1.000 15.590 0 289 ARG A C   1 ? 
ATOM   2282 O  O   . ARG A 1 289 ? -1.155  22.725  16.935  1.000 17.094 0 289 ARG A O   1 ? 
ATOM   2283 C  CB  . ARG A 1 289 ? 1.166   24.184  18.790  1.000 19.797 0 289 ARG A CB  1 ? 
ATOM   2284 C  CG  . ARG A 1 289 ? 1.009   25.537  19.474  1.000 30.343 0 289 ARG A CG  1 ? 
ATOM   2285 C  CD  . ARG A 1 289 ? 1.904   26.616  18.853  1.000 39.377 0 289 ARG A CD  1 ? 
ATOM   2286 N  NE  . ARG A 1 289 ? 3.314   26.250  19.036  1.000 42.934 0 289 ARG A NE  1 ? 
ATOM   2287 C  CZ  . ARG A 1 289 ? 3.940   26.188  20.208  1.000 48.176 0 289 ARG A CZ  1 ? 
ATOM   2288 N  NH1 . ARG A 1 289 ? 3.341   26.627  21.305  1.000 51.078 0 289 ARG A NH1 1 ? 
ATOM   2289 N  NH2 . ARG A 1 289 ? 5.171   25.717  20.276  1.000 39.519 0 289 ARG A NH2 1 ? 
ATOM   2290 N  N   . LEU A 1 290 ? 0.343   21.269  17.762  1.000 13.313 0 290 LEU A N   1 ? 
ATOM   2291 C  CA  . LEU A 1 290 ? 0.175   20.355  16.644  1.000 13.008 0 290 LEU A CA  1 ? 
ATOM   2292 C  C   . LEU A 1 290 ? -1.199  19.679  16.621  1.000 14.488 0 290 LEU A C   1 ? 
ATOM   2293 O  O   . LEU A 1 290 ? -1.754  19.387  15.556  1.000 15.771 0 290 LEU A O   1 ? 
ATOM   2294 C  CB  . LEU A 1 290 ? 1.288   19.312  16.681  1.000 13.400 0 290 LEU A CB  1 ? 
ATOM   2295 C  CG  . LEU A 1 290 ? 2.680   19.818  16.299  1.000 13.951 0 290 LEU A CG  1 ? 
ATOM   2296 C  CD1 . LEU A 1 290 ? 3.702   18.718  16.655  1.000 15.476 0 290 LEU A CD1 1 ? 
ATOM   2297 C  CD2 . LEU A 1 290 ? 2.792   20.234  14.843  1.000 16.375 0 290 LEU A CD2 1 ? 
ATOM   2298 N  N   . TYR A 1 291 ? -1.708  19.279  17.801  1.000 13.083 0 291 TYR A N   1 ? 
ATOM   2299 C  CA  . TYR A 1 291 ? -2.759  18.281  17.886  1.000 12.524 0 291 TYR A CA  1 ? 
ATOM   2300 C  C   . TYR A 1 291 ? -4.038  18.795  18.553  1.000 12.222 0 291 TYR A C   1 ? 
ATOM   2301 O  O   . TYR A 1 291 ? -5.060  18.105  18.510  1.000 13.335 0 291 TYR A O   1 ? 
ATOM   2302 C  CB  . TYR A 1 291 ? -2.244  17.025  18.599  1.000 12.714 0 291 TYR A CB  1 ? 
ATOM   2303 C  CG  . TYR A 1 291 ? -1.066  16.446  17.840  1.000 12.012 0 291 TYR A CG  1 ? 
ATOM   2304 C  CD1 . TYR A 1 291 ? -1.195  15.973  16.524  1.000 12.345 0 291 TYR A CD1 1 ? 
ATOM   2305 C  CD2 . TYR A 1 291 ? 0.172   16.345  18.452  1.000 12.827 0 291 TYR A CD2 1 ? 
ATOM   2306 C  CE1 . TYR A 1 291 ? -0.104  15.516  15.818  1.000 12.859 0 291 TYR A CE1 1 ? 
ATOM   2307 C  CE2 . TYR A 1 291 ? 1.260   15.855  17.756  1.000 12.842 0 291 TYR A CE2 1 ? 
ATOM   2308 C  CZ  . TYR A 1 291 ? 1.115   15.415  16.458  1.000 12.881 0 291 TYR A CZ  1 ? 
ATOM   2309 O  OH  . TYR A 1 291 ? 2.250   14.962  15.800  1.000 14.767 0 291 TYR A OH  1 ? 
ATOM   2310 N  N   . GLY A 1 292 ? -3.949  19.966  19.160  1.000 12.299 0 292 GLY A N   1 ? 
ATOM   2311 C  CA  . GLY A 1 292 ? -5.120  20.641  19.706  1.000 13.498 0 292 GLY A CA  1 ? 
ATOM   2312 C  C   . GLY A 1 292 ? -5.668  19.965  20.962  1.000 14.193 0 292 GLY A C   1 ? 
ATOM   2313 O  O   . GLY A 1 292 ? -6.807  20.245  21.346  1.000 14.258 0 292 GLY A O   1 ? 
ATOM   2314 N  N   . LYS A 1 293 ? -4.871  19.106  21.611  1.000 11.852 0 293 LYS A N   1 ? 
ATOM   2315 C  CA  . LYS A 1 293 ? -5.207  18.400  22.854  1.000 10.995 0 293 LYS A CA  1 ? 
ATOM   2316 C  C   . LYS A 1 293 ? -3.964  18.378  23.722  1.000 10.449 0 293 LYS A C   1 ? 
ATOM   2317 O  O   . LYS A 1 293 ? -2.858  18.565  23.194  1.000 10.484 0 293 LYS A O   1 ? 
ATOM   2318 C  CB  . LYS A 1 293 ? -5.568  16.943  22.609  1.000 11.882 0 293 LYS A CB  1 ? 
ATOM   2319 C  CG  . LYS A 1 293 ? -6.687  16.683  21.608  1.000 12.853 0 293 LYS A CG  1 ? 
ATOM   2320 C  CD  . LYS A 1 293 ? -8.028  17.215  22.058  1.000 13.068 0 293 LYS A CD  1 ? 
ATOM   2321 C  CE  . LYS A 1 293 ? -9.124  16.555  21.292  1.000 16.270 0 293 LYS A CE  1 ? 
ATOM   2322 N  NZ  . LYS A 1 293 ? -10.266 17.426  21.152  1.000 19.044 0 293 LYS A NZ  1 ? 
ATOM   2323 N  N   . SER A 1 294 ? -4.151  18.291  25.037  1.000 9.660  0 294 SER A N   1 ? 
ATOM   2324 C  CA  . SER A 1 294 ? -2.980  18.220  25.909  1.000 9.282  0 294 SER A CA  1 ? 
ATOM   2325 C  C   . SER A 1 294 ? -2.322  16.834  25.846  1.000 9.097  0 294 SER A C   1 ? 
ATOM   2326 O  O   . SER A 1 294 ? -2.970  15.806  25.711  1.000 9.426  0 294 SER A O   1 ? 
ATOM   2327 C  CB  . SER A 1 294 ? -3.340  18.534  27.341  1.000 10.751 0 294 SER A CB  1 ? 
ATOM   2328 O  OG  . SER A 1 294 ? -4.206  17.556  27.890  1.000 10.957 0 294 SER A OG  1 ? 
ATOM   2329 N  N   . LEU A 1 295 ? -0.975  16.846  25.980  1.000 8.942  0 295 LEU A N   1 ? 
ATOM   2330 C  CA  . LEU A 1 295 ? -0.233  15.591  26.135  1.000 9.170  0 295 LEU A CA  1 ? 
ATOM   2331 C  C   . LEU A 1 295 ? -0.773  14.800  27.329  1.000 8.180  0 295 LEU A C   1 ? 
ATOM   2332 O  O   . LEU A 1 295 ? -0.972  13.595  27.296  1.000 8.529  0 295 LEU A O   1 ? 
ATOM   2333 C  CB  . LEU A 1 295 ? 1.259   15.824  26.253  1.000 8.883  0 295 LEU A CB  1 ? 
ATOM   2334 C  CG  . LEU A 1 295 ? 2.103   14.585  26.568  1.000 8.972  0 295 LEU A CG  1 ? 
ATOM   2335 C  CD1 . LEU A 1 295 ? 1.990   13.505  25.471  1.000 8.595  0 295 LEU A CD1 1 ? 
ATOM   2336 C  CD2 . LEU A 1 295 ? 3.565   14.950  26.736  1.000 9.887  0 295 LEU A CD2 1 ? 
ATOM   2337 N  N   . TYR A 1 296 ? -1.007  15.518  28.449  1.000 9.844  0 296 TYR A N   1 ? 
ATOM   2338 C  CA  . TYR A 1 296 ? -1.540  14.940  29.671  1.000 10.471 0 296 TYR A CA  1 ? 
ATOM   2339 C  C   . TYR A 1 296 ? -2.792  14.106  29.382  1.000 10.574 0 296 TYR A C   1 ? 
ATOM   2340 O  O   . TYR A 1 296 ? -2.907  12.973  29.844  1.000 9.882  0 296 TYR A O   1 ? 
ATOM   2341 C  CB  . TYR A 1 296 ? -1.860  16.101  30.610  1.000 13.335 0 296 TYR A CB  1 ? 
ATOM   2342 C  CG  . TYR A 1 296 ? -2.310  15.650  31.987  1.000 18.744 0 296 TYR A CG  1 ? 
ATOM   2343 C  CD1 . TYR A 1 296 ? -1.393  15.430  33.007  1.000 16.052 0 296 TYR A CD1 1 ? 
ATOM   2344 C  CD2 . TYR A 1 296 ? -3.647  15.444  32.230  1.000 23.804 0 296 TYR A CD2 1 ? 
ATOM   2345 C  CE1 . TYR A 1 296 ? -1.807  15.015  34.267  1.000 22.246 0 296 TYR A CE1 1 ? 
ATOM   2346 C  CE2 . TYR A 1 296 ? -4.082  15.022  33.485  1.000 26.154 0 296 TYR A CE2 1 ? 
ATOM   2347 C  CZ  . TYR A 1 296 ? -3.159  14.809  34.482  1.000 23.572 0 296 TYR A CZ  1 ? 
ATOM   2348 O  OH  . TYR A 1 296 ? -3.575  14.402  35.737  1.000 27.430 0 296 TYR A OH  1 ? 
ATOM   2349 N  N   . SER A 1 297 ? -3.725  14.709  28.601  1.000 10.111 0 297 SER A N   1 ? 
ATOM   2350 C  CA  . SER A 1 297 ? -4.980  14.029  28.351  1.000 10.422 0 297 SER A CA  1 ? 
ATOM   2351 C  C   . SER A 1 297 ? -4.789  12.766  27.507  1.000 9.704  0 297 SER A C   1 ? 
ATOM   2352 O  O   . SER A 1 297 ? -5.480  11.766  27.665  1.000 11.345 0 297 SER A O   1 ? 
ATOM   2353 C  CB  . SER A 1 297 ? -5.991  14.937  27.680  1.000 10.268 0 297 SER A CB  1 ? 
ATOM   2354 O  OG  . SER A 1 297 ? -5.640  15.191  26.339  1.000 10.689 0 297 SER A OG  1 ? 
ATOM   2355 N  N   . PHE A 1 298 ? -3.781  12.781  26.615  1.000 9.881  0 298 PHE A N   1 ? 
ATOM   2356 C  CA  . PHE A 1 298 ? -3.516  11.616  25.794  1.000 9.076  0 298 PHE A CA  1 ? 
ATOM   2357 C  C   . PHE A 1 298 ? -3.041  10.487  26.685  1.000 9.592  0 298 PHE A C   1 ? 
ATOM   2358 O  O   . PHE A 1 298 ? -3.479  9.348   26.577  1.000 10.153 0 298 PHE A O   1 ? 
ATOM   2359 C  CB  . PHE A 1 298 ? -2.475  11.893  24.707  1.000 10.882 0 298 PHE A CB  1 ? 
ATOM   2360 C  CG  . PHE A 1 298 ? -3.038  12.098  23.329  1.000 10.937 0 298 PHE A CG  1 ? 
ATOM   2361 C  CD1 . PHE A 1 298 ? -3.920  13.132  23.084  1.000 12.647 0 298 PHE A CD1 1 ? 
ATOM   2362 C  CD2 . PHE A 1 298 ? -2.652  11.316  22.249  1.000 13.459 0 298 PHE A CD2 1 ? 
ATOM   2363 C  CE1 . PHE A 1 298 ? -4.444  13.320  21.835  1.000 13.936 0 298 PHE A CE1 1 ? 
ATOM   2364 C  CE2 . PHE A 1 298 ? -3.169  11.545  20.978  1.000 14.962 0 298 PHE A CE2 1 ? 
ATOM   2365 C  CZ  . PHE A 1 298 ? -4.065  12.559  20.795  1.000 14.819 0 298 PHE A CZ  1 ? 
ATOM   2366 N  N   . ILE A 1 299 ? -2.032  10.784  27.535  1.000 9.261  0 299 ILE A N   1 ? 
ATOM   2367 C  CA  . ILE A 1 299 ? -1.509  9.745   28.416  1.000 9.217  0 299 ILE A CA  1 ? 
ATOM   2368 C  C   . ILE A 1 299 ? -2.619  9.214   29.325  1.000 10.209 0 299 ILE A C   1 ? 
ATOM   2369 O  O   . ILE A 1 299 ? -2.760  8.025   29.544  1.000 10.682 0 299 ILE A O   1 ? 
ATOM   2370 C  CB  . ILE A 1 299 ? -0.332  10.305  29.235  1.000 9.715  0 299 ILE A CB  1 ? 
ATOM   2371 C  CG1 . ILE A 1 299 ? 0.858   10.666  28.332  1.000 9.064  0 299 ILE A CG1 1 ? 
ATOM   2372 C  CG2 . ILE A 1 299 ? 0.081   9.357   30.342  1.000 10.479 0 299 ILE A CG2 1 ? 
ATOM   2373 C  CD1 . ILE A 1 299 ? 1.951   11.456  29.030  1.000 9.657  0 299 ILE A CD1 1 ? 
ATOM   2374 N  N   . LYS A 1 300 ? -3.439  10.118  29.887  1.000 11.180 0 300 LYS A N   1 ? 
ATOM   2375 C  CA  . LYS A 1 300 ? -4.454  9.679   30.819  1.000 12.816 0 300 LYS A CA  1 ? 
ATOM   2376 C  C   . LYS A 1 300 ? -5.466  8.747   30.128  1.000 12.009 0 300 LYS A C   1 ? 
ATOM   2377 O  O   . LYS A 1 300 ? -5.948  7.782   30.736  1.000 13.847 0 300 LYS A O   1 ? 
ATOM   2378 C  CB  . LYS A 1 300 ? -5.109  10.932  31.394  1.000 14.108 0 300 LYS A CB  1 ? 
ATOM   2379 C  CG  . LYS A 1 300 ? -6.199  10.585  32.394  1.000 16.050 0 300 LYS A CG  1 ? 
ATOM   2380 C  CD  . LYS A 1 300 ? -6.820  11.761  33.110  1.000 20.650 0 300 LYS A CD  1 ? 
ATOM   2381 C  CE  . LYS A 1 300 ? -7.644  12.521  32.105  1.000 24.133 0 300 LYS A CE  1 ? 
ATOM   2382 N  NZ  . LYS A 1 300 ? -8.339  13.623  32.761  1.000 28.426 0 300 LYS A NZ  1 ? 
ATOM   2383 N  N   . GLY A 1 301 ? -5.778  9.033   28.863  1.000 13.990 0 301 GLY A N   1 ? 
ATOM   2384 C  CA  . GLY A 1 301 ? -6.745  8.230   28.128  1.000 15.650 0 301 GLY A CA  1 ? 
ATOM   2385 C  C   . GLY A 1 301 ? -6.184  6.928   27.575  1.000 18.233 0 301 GLY A C   1 ? 
ATOM   2386 O  O   . GLY A 1 301 ? -6.939  6.021   27.206  1.000 20.876 0 301 GLY A O   1 ? 
ATOM   2387 N  N   . ASP A 1 302 ? -4.868  6.780   27.496  1.000 14.065 0 302 ASP A N   1 ? 
ATOM   2388 C  CA  . ASP A 1 302 ? -4.288  5.637   26.820  1.000 15.155 0 302 ASP A CA  1 ? 
ATOM   2389 C  C   . ASP A 1 302 ? -3.649  4.638   27.775  1.000 14.816 0 302 ASP A C   1 ? 
ATOM   2390 O  O   . ASP A 1 302 ? -3.182  3.590   27.303  1.000 16.129 0 302 ASP A O   1 ? 
ATOM   2391 C  CB  . ASP A 1 302 ? -3.278  6.069   25.766  1.000 17.183 0 302 ASP A CB  1 ? 
ATOM   2392 C  CG  . ASP A 1 302 ? -3.530  5.505   24.374  1.000 21.439 0 302 ASP A CG  1 ? 
ATOM   2393 O  OD1 . ASP A 1 302 ? -4.608  5.841   23.827  1.000 26.196 0 302 ASP A OD1 1 ? 
ATOM   2394 O  OD2 . ASP A 1 302 ? -2.626  4.845   23.800  1.000 27.241 0 302 ASP A OD2 1 ? 
ATOM   2395 N  N   . THR A 1 303 ? -3.512  4.966   29.080  1.000 12.839 0 303 THR A N   1 ? 
ATOM   2396 C  CA  . THR A 1 303 ? -2.786  4.143   30.030  1.000 13.782 0 303 THR A CA  1 ? 
ATOM   2397 C  C   . THR A 1 303 ? -3.624  4.073   31.296  1.000 12.960 0 303 THR A C   1 ? 
ATOM   2398 O  O   . THR A 1 303 ? -4.543  4.864   31.486  1.000 14.910 0 303 THR A O   1 ? 
ATOM   2399 C  CB  . THR A 1 303 ? -1.398  4.712   30.317  1.000 11.726 0 303 THR A CB  1 ? 
ATOM   2400 O  OG1 . THR A 1 303 ? -1.465  5.975   30.985  1.000 12.092 0 303 THR A OG1 1 ? 
ATOM   2401 C  CG2 . THR A 1 303 ? -0.594  4.822   29.038  1.000 12.484 0 303 THR A CG2 1 ? 
ATOM   2402 N  N   . SER A 1 304 ? -3.268  3.132   32.163  1.000 13.781 0 304 SER A N   1 ? 
ATOM   2403 C  CA  . SER A 1 304 ? -3.958  2.996   33.434  1.000 14.755 0 304 SER A CA  1 ? 
ATOM   2404 C  C   . SER A 1 304 ? -2.997  2.612   34.552  1.000 13.738 0 304 SER A C   1 ? 
ATOM   2405 O  O   . SER A 1 304 ? -1.817  2.324   34.366  1.000 12.199 0 304 SER A O   1 ? 
ATOM   2406 C  CB  . SER A 1 304 ? -5.106  1.981   33.288  1.000 20.773 0 304 SER A CB  1 ? 
ATOM   2407 O  OG  . SER A 1 304 ? -4.562  0.693   33.112  1.000 27.215 0 304 SER A OG  1 ? 
ATOM   2408 N  N   . GLY A 1 305 ? -3.539  2.579   35.754  1.000 13.208 0 305 GLY A N   1 ? 
ATOM   2409 C  CA  . GLY A 1 305 ? -2.866  1.989   36.884  1.000 12.742 0 305 GLY A CA  1 ? 
ATOM   2410 C  C   . GLY A 1 305 ? -1.650  2.817   37.300  1.000 11.185 0 305 GLY A C   1 ? 
ATOM   2411 O  O   . GLY A 1 305 ? -1.619  4.035   37.103  1.000 11.580 0 305 GLY A O   1 ? 
ATOM   2412 N  N   . ASP A 1 306 ? -0.658  2.146   37.895  1.000 11.059 0 306 ASP A N   1 ? 
ATOM   2413 C  CA  . ASP A 1 306 ? 0.523   2.828   38.382  1.000 10.456 0 306 ASP A CA  1 ? 
ATOM   2414 C  C   . ASP A 1 306 ? 1.373   3.336   37.200  1.000 9.855  0 306 ASP A C   1 ? 
ATOM   2415 O  O   . ASP A 1 306 ? 2.082   4.339   37.306  1.000 9.969  0 306 ASP A O   1 ? 
ATOM   2416 C  CB  . ASP A 1 306 ? 1.363   1.909   39.258  1.000 11.128 0 306 ASP A CB  1 ? 
ATOM   2417 C  CG  . ASP A 1 306 ? 0.670   1.479   40.533  1.000 15.208 0 306 ASP A CG  1 ? 
ATOM   2418 O  OD1 . ASP A 1 306 ? 0.171   2.367   41.176  1.000 16.505 0 306 ASP A OD1 1 ? 
ATOM   2419 O  OD2 . ASP A 1 306 ? 0.714   0.278   40.824  1.000 16.017 0 306 ASP A OD2 1 ? 
ATOM   2420 N  N   . TYR A 1 307 ? 1.356   2.615   36.078  1.000 9.895  0 307 TYR A N   1 ? 
ATOM   2421 C  CA  . TYR A 1 307 ? 1.966   3.061   34.831  1.000 9.744  0 307 TYR A CA  1 ? 
ATOM   2422 C  C   . TYR A 1 307 ? 1.480   4.444   34.419  1.000 9.308  0 307 TYR A C   1 ? 
ATOM   2423 O  O   . TYR A 1 307 ? 2.282   5.381   34.236  1.000 9.032  0 307 TYR A O   1 ? 
ATOM   2424 C  CB  . TYR A 1 307 ? 1.645   2.011   33.782  1.000 9.528  0 307 TYR A CB  1 ? 
ATOM   2425 C  CG  . TYR A 1 307 ? 2.134   2.251   32.370  1.000 9.605  0 307 TYR A CG  1 ? 
ATOM   2426 C  CD1 . TYR A 1 307 ? 3.399   2.739   32.086  1.000 10.347 0 307 TYR A CD1 1 ? 
ATOM   2427 C  CD2 . TYR A 1 307 ? 1.327   1.931   31.293  1.000 9.982  0 307 TYR A CD2 1 ? 
ATOM   2428 C  CE1 . TYR A 1 307 ? 3.842   2.868   30.785  1.000 9.722  0 307 TYR A CE1 1 ? 
ATOM   2429 C  CE2 . TYR A 1 307 ? 1.757   2.101   29.983  1.000 9.799  0 307 TYR A CE2 1 ? 
ATOM   2430 C  CZ  . TYR A 1 307 ? 3.038   2.536   29.741  1.000 9.669  0 307 TYR A CZ  1 ? 
ATOM   2431 O  OH  . TYR A 1 307 ? 3.502   2.663   28.456  1.000 10.563 0 307 TYR A OH  1 ? 
ATOM   2432 N  N   . ARG A 1 308 ? 0.161   4.651   34.367  1.000 8.562  0 308 ARG A N   1 ? 
ATOM   2433 C  CA  . ARG A 1 308 ? -0.404  5.958   34.112  1.000 8.692  0 308 ARG A CA  1 ? 
ATOM   2434 C  C   . ARG A 1 308 ? 0.070   6.964   35.145  1.000 8.746  0 308 ARG A C   1 ? 
ATOM   2435 O  O   . ARG A 1 308 ? 0.462   8.067   34.794  1.000 9.428  0 308 ARG A O   1 ? 
ATOM   2436 C  CB  . ARG A 1 308 ? -1.942  5.871   34.091  1.000 9.737  0 308 ARG A CB  1 ? 
ATOM   2437 C  CG  . ARG A 1 308 ? -2.585  7.247   34.070  1.000 9.837  0 308 ARG A CG  1 ? 
ATOM   2438 C  CD  . ARG A 1 308 ? -4.043  7.279   33.637  1.000 10.818 0 308 ARG A CD  1 ? 
ATOM   2439 N  NE  . ARG A 1 308 ? -4.830  6.423   34.525  1.000 12.843 0 308 ARG A NE  1 ? 
ATOM   2440 C  CZ  . ARG A 1 308 ? -6.158  6.288   34.412  1.000 14.932 0 308 ARG A CZ  1 ? 
ATOM   2441 N  NH1 . ARG A 1 308 ? -6.756  6.828   33.393  1.000 15.839 0 308 ARG A NH1 1 ? 
ATOM   2442 N  NH2 . ARG A 1 308 ? -6.866  5.633   35.331  1.000 18.244 0 308 ARG A NH2 1 ? 
ATOM   2443 N  N   . LYS A 1 309 ? -0.000  6.615   36.435  1.000 8.438  0 309 LYS A N   1 ? 
ATOM   2444 C  CA  . LYS A 1 309 ? 0.358   7.564   37.472  1.000 8.655  0 309 LYS A CA  1 ? 
ATOM   2445 C  C   . LYS A 1 309 ? 1.762   8.130   37.251  1.000 8.699  0 309 LYS A C   1 ? 
ATOM   2446 O  O   . LYS A 1 309 ? 1.965   9.340   37.333  1.000 9.735  0 309 LYS A O   1 ? 
ATOM   2447 C  CB  . LYS A 1 309 ? 0.234   6.914   38.860  1.000 10.680 0 309 LYS A CB  1 ? 
ATOM   2448 C  CG  . LYS A 1 309 ? -1.203  6.639   39.338  1.000 13.227 0 309 LYS A CG  1 ? 
ATOM   2449 C  CD  . LYS A 1 309 ? -1.240  5.846   40.651  1.000 14.926 0 309 LYS A CD  1 ? 
ATOM   2450 C  CE  . LYS A 1 309 ? -2.649  5.739   41.137  1.000 18.437 0 309 LYS A CE  1 ? 
ATOM   2451 N  NZ  . LYS A 1 309 ? -2.674  4.914   42.355  1.000 22.722 0 309 LYS A NZ  1 ? 
ATOM   2452 N  N   . VAL A 1 310 ? 2.738   7.250   37.000  1.000 8.580  0 310 VAL A N   1 ? 
ATOM   2453 C  CA  . VAL A 1 310 ? 4.114   7.705   36.892  1.000 8.104  0 310 VAL A CA  1 ? 
ATOM   2454 C  C   . VAL A 1 310 ? 4.303   8.482   35.585  1.000 7.913  0 310 VAL A C   1 ? 
ATOM   2455 O  O   . VAL A 1 310 ? 4.991   9.493   35.591  1.000 8.234  0 310 VAL A O   1 ? 
ATOM   2456 C  CB  . VAL A 1 310 ? 5.142   6.573   37.109  1.000 9.264  0 310 VAL A CB  1 ? 
ATOM   2457 C  CG1 . VAL A 1 310 ? 5.099   5.495   36.045  1.000 9.411  0 310 VAL A CG1 1 ? 
ATOM   2458 C  CG2 . VAL A 1 310 ? 6.551   7.152   37.285  1.000 10.293 0 310 VAL A CG2 1 ? 
ATOM   2459 N  N   . LEU A 1 311 ? 3.700   8.048   34.482  1.000 7.707  0 311 LEU A N   1 ? 
ATOM   2460 C  CA  . LEU A 1 311 ? 3.838   8.800   33.239  1.000 7.702  0 311 LEU A CA  1 ? 
ATOM   2461 C  C   . LEU A 1 311 ? 3.251   10.193  33.397  1.000 8.272  0 311 LEU A C   1 ? 
ATOM   2462 O  O   . LEU A 1 311 ? 3.790   11.149  32.821  1.000 8.979  0 311 LEU A O   1 ? 
ATOM   2463 C  CB  . LEU A 1 311 ? 3.195   8.104   32.058  1.000 9.316  0 311 LEU A CB  1 ? 
ATOM   2464 C  CG  . LEU A 1 311 ? 3.814   6.814   31.569  1.000 9.689  0 311 LEU A CG  1 ? 
ATOM   2465 C  CD1 . LEU A 1 311 ? 3.015   6.301   30.381  1.000 11.591 0 311 LEU A CD1 1 ? 
ATOM   2466 C  CD2 . LEU A 1 311 ? 5.284   7.022   31.173  1.000 11.091 0 311 LEU A CD2 1 ? 
ATOM   2467 N  N   . LEU A 1 312 ? 2.160   10.340  34.165  1.000 8.250  0 312 LEU A N   1 ? 
ATOM   2468 C  CA  . LEU A 1 312 ? 1.572   11.660  34.346  1.000 8.439  0 312 LEU A CA  1 ? 
ATOM   2469 C  C   . LEU A 1 312 ? 2.436   12.578  35.218  1.000 8.716  0 312 LEU A C   1 ? 
ATOM   2470 O  O   . LEU A 1 312 ? 2.465   13.776  34.969  1.000 9.539  0 312 LEU A O   1 ? 
ATOM   2471 C  CB  . LEU A 1 312 ? 0.165   11.568  34.944  1.000 8.937  0 312 LEU A CB  1 ? 
ATOM   2472 C  CG  . LEU A 1 312 ? -0.874  10.965  34.010  1.000 10.128 0 312 LEU A CG  1 ? 
ATOM   2473 C  CD1 . LEU A 1 312 ? -2.236  10.874  34.727  1.000 10.827 0 312 LEU A CD1 1 ? 
ATOM   2474 C  CD2 . LEU A 1 312 ? -1.030  11.802  32.757  1.000 10.505 0 312 LEU A CD2 1 ? 
ATOM   2475 N  N   . VAL A 1 313 ? 3.240   12.046  36.154  1.000 9.833  0 313 VAL A N   1 ? 
ATOM   2476 C  CA  . VAL A 1 313 ? 4.201   12.862  36.889  1.000 9.819  0 313 VAL A CA  1 ? 
ATOM   2477 C  C   . VAL A 1 313 ? 5.310   13.289  35.929  1.000 9.209  0 313 VAL A C   1 ? 
ATOM   2478 O  O   . VAL A 1 313 ? 5.745   14.427  35.957  1.000 11.826 0 313 VAL A O   1 ? 
ATOM   2479 C  CB  . VAL A 1 313 ? 4.790   12.183  38.129  1.000 10.218 0 313 VAL A CB  1 ? 
ATOM   2480 C  CG1 . VAL A 1 313 ? 5.803   13.075  38.811  1.000 10.366 0 313 VAL A CG1 1 ? 
ATOM   2481 C  CG2 . VAL A 1 313 ? 3.655   11.815  39.076  1.000 10.959 0 313 VAL A CG2 1 ? 
ATOM   2482 N  N   . LEU A 1 314 ? 5.813   12.380  35.105  1.000 9.065  0 314 LEU A N   1 ? 
ATOM   2483 C  CA  . LEU A 1 314 ? 6.854   12.738  34.146  1.000 9.231  0 314 LEU A CA  1 ? 
ATOM   2484 C  C   . LEU A 1 314 ? 6.362   13.824  33.202  1.000 9.493  0 314 LEU A C   1 ? 
ATOM   2485 O  O   . LEU A 1 314 ? 7.160   14.650  32.751  1.000 9.884  0 314 LEU A O   1 ? 
ATOM   2486 C  CB  . LEU A 1 314 ? 7.382   11.515  33.377  1.000 8.846  0 314 LEU A CB  1 ? 
ATOM   2487 C  CG  . LEU A 1 314 ? 8.060   10.415  34.184  1.000 9.168  0 314 LEU A CG  1 ? 
ATOM   2488 C  CD1 . LEU A 1 314 ? 8.424   9.260   33.283  1.000 9.697  0 314 LEU A CD1 1 ? 
ATOM   2489 C  CD2 . LEU A 1 314 ? 9.254   10.910  34.979  1.000 11.021 0 314 LEU A CD2 1 ? 
ATOM   2490 N  N   . CYS A 1 315 ? 5.087   13.774  32.816  1.000 8.513  0 315 CYS A N   1 ? 
ATOM   2491 C  CA  . CYS A 1 315 ? 4.554   14.776  31.910  1.000 8.942  0 315 CYS A CA  1 ? 
ATOM   2492 C  C   . CYS A 1 315 ? 4.407   16.138  32.614  1.000 11.341 0 315 CYS A C   1 ? 
ATOM   2493 O  O   . CYS A 1 315 ? 4.779   17.182  32.044  1.000 13.659 0 315 CYS A O   1 ? 
ATOM   2494 C  CB  . CYS A 1 315 ? 3.190   14.297  31.458  1.000 9.770  0 315 CYS A CB  1 ? 
ATOM   2495 S  SG  . CYS A 1 315 ? 2.316   15.346  30.278  1.000 12.146 0 315 CYS A SG  1 ? 
ATOM   2496 N  N   . GLY A 1 316 ? 3.967   16.117  33.861  1.000 11.409 0 316 GLY A N   1 ? 
ATOM   2497 C  CA  . GLY A 1 316 ? 3.495   17.312  34.541  1.000 13.918 0 316 GLY A CA  1 ? 
ATOM   2498 C  C   . GLY A 1 316 ? 2.028   17.575  34.186  1.000 16.825 0 316 GLY A C   1 ? 
ATOM   2499 O  O   . GLY A 1 316 ? 1.519   17.130  33.169  1.000 19.570 0 316 GLY A O   1 ? 
ATOM   2500 N  N   . GLY A 1 317 ? 1.362   18.370  35.040  1.000 23.012 0 317 GLY A N   1 ? 
ATOM   2501 C  CA  . GLY A 1 317 ? -0.004  18.800  34.757  1.000 25.038 0 317 GLY A CA  1 ? 
ATOM   2502 C  C   . GLY A 1 317 ? -0.992  18.143  35.726  1.000 32.723 0 317 GLY A C   1 ? 
ATOM   2503 O  O   . GLY A 1 317 ? -0.589  17.499  36.695  1.000 32.674 0 317 GLY A O   1 ? 
ATOM   2504 N  N   . ASP A 1 318 ? -2.302  18.221  35.475  1.000 35.810 0 318 ASP A N   1 ? 
ATOM   2505 C  CA  . ASP A 1 318 ? -3.041  19.167  34.650  1.000 38.524 0 318 ASP A CA  1 ? 
ATOM   2506 C  C   . ASP A 1 318 ? -4.469  19.121  35.205  1.000 38.959 0 318 ASP A C   1 ? 
ATOM   2507 O  O   . ASP A 1 318 ? -5.403  18.964  34.425  1.000 56.816 0 318 ASP A O   1 ? 
ATOM   2508 C  CB  . ASP A 1 318 ? -3.010  18.854  33.151  1.000 44.113 0 318 ASP A CB  1 ? 
ATOM   2509 C  CG  . ASP A 1 318 ? -2.128  19.714  32.247  1.000 46.811 0 318 ASP A CG  1 ? 
ATOM   2510 O  OD1 . ASP A 1 318 ? -1.269  20.454  32.792  1.000 50.268 0 318 ASP A OD1 1 ? 
ATOM   2511 O  OD2 . ASP A 1 318 ? -2.286  19.639  30.990  1.000 53.272 0 318 ASP A OD2 1 ? 
ATOM   2512 N  N   . ASP A 1 319 ? -4.624  19.186  36.547  1.000 45.769 0 319 ASP A N   1 ? 
ATOM   2513 C  CA  . ASP A 1 319 ? -5.944  19.206  37.163  1.000 40.779 0 319 ASP A CA  1 ? 
ATOM   2514 C  C   . ASP A 1 319 ? -6.016  18.536  38.549  1.000 34.251 0 319 ASP A C   1 ? 
ATOM   2515 O  O   . ASP A 1 319 ? -7.116  17.967  38.795  1.000 23.924 0 319 ASP A O   1 ? 
ATOM   2516 C  CB  . ASP A 1 319 ? -6.999  18.610  36.223  1.000 49.646 0 319 ASP A CB  1 ? 
ATOM   2517 C  CG  . ASP A 1 319 ? -6.877  17.188  35.676  1.000 41.765 0 319 ASP A CG  1 ? 
ATOM   2518 O  OD1 . ASP A 1 319 ? -6.957  16.250  36.488  1.000 45.115 0 319 ASP A OD1 1 ? 
ATOM   2519 O  OD2 . ASP A 1 319 ? -6.829  17.034  34.429  1.000 51.220 0 319 ASP A OD2 1 ? 
HETATM 2520 CA CA  . CA  B 2 .   ? 6.880   -6.709  49.034  1.000 11.335 0 401 CA  A CA  1 ? 
HETATM 2521 CA CA  . CA  C 2 .   ? 18.806  -7.747  14.773  1.000 28.276 0 402 CA  A CA  1 ? 
HETATM 2522 CA CA  . CA  D 2 .   ? -4.316  4.320   21.676  1.000 24.235 0 403 CA  A CA  1 ? 
HETATM 2523 C  C1  . GOL E 3 .   ? 19.767  30.944  2.763   1.000 11.807 0 404 GOL A C1  1 ? 
HETATM 2524 O  O1  . GOL E 3 .   ? 20.921  30.796  3.581   1.000 32.757 0 404 GOL A O1  1 ? 
HETATM 2525 C  C2  . GOL E 3 .   ? 20.030  32.065  1.817   1.000 15.440 0 404 GOL A C2  1 ? 
HETATM 2526 O  O2  . GOL E 3 .   ? 20.619  31.570  0.606   1.000 23.669 0 404 GOL A O2  1 ? 
HETATM 2527 C  C3  . GOL E 3 .   ? 20.895  33.073  2.520   1.000 14.275 0 404 GOL A C3  1 ? 
HETATM 2528 O  O3  . GOL E 3 .   ? 20.226  33.619  3.671   1.000 14.144 0 404 GOL A O3  1 ? 
HETATM 2529 C  C1  . GOL F 3 .   ? 28.532  6.816   6.747   1.000 28.457 0 405 GOL A C1  1 ? 
HETATM 2530 O  O1  . GOL F 3 .   ? 29.045  8.078   7.219   1.000 26.988 0 405 GOL A O1  1 ? 
HETATM 2531 C  C2  . GOL F 3 .   ? 28.424  6.757   5.250   1.000 33.203 0 405 GOL A C2  1 ? 
HETATM 2532 O  O2  . GOL F 3 .   ? 28.518  5.458   4.651   1.000 27.705 0 405 GOL A O2  1 ? 
HETATM 2533 C  C3  . GOL F 3 .   ? 29.425  7.644   4.560   1.000 29.623 0 405 GOL A C3  1 ? 
HETATM 2534 O  O3  . GOL F 3 .   ? 28.616  8.526   3.812   1.000 20.362 0 405 GOL A O3  1 ? 
HETATM 2535 C  C1  . GOL G 3 .   ? 28.515  -6.857  9.356   1.000 13.114 0 406 GOL A C1  1 ? 
HETATM 2536 O  O1  . GOL G 3 .   ? 28.023  -7.136  8.058   1.000 37.094 0 406 GOL A O1  1 ? 
HETATM 2537 C  C2  . GOL G 3 .   ? 29.721  -5.948  9.202   1.000 24.949 0 406 GOL A C2  1 ? 
HETATM 2538 O  O2  . GOL G 3 .   ? 30.035  -5.324  10.453  1.000 32.421 0 406 GOL A O2  1 ? 
HETATM 2539 C  C3  . GOL G 3 .   ? 29.551  -4.886  8.140   1.000 33.613 0 406 GOL A C3  1 ? 
HETATM 2540 O  O3  . GOL G 3 .   ? 30.714  -4.762  7.325   1.000 37.521 0 406 GOL A O3  1 ? 
HETATM 2541 S  S   . SO4 H 4 .   ? 14.831  -4.035  57.316  1.000 17.101 0 407 SO4 A S   1 ? 
HETATM 2542 O  O1  . SO4 H 4 .   ? 14.447  -5.397  57.045  1.000 18.876 0 407 SO4 A O1  1 ? 
HETATM 2543 O  O2  . SO4 H 4 .   ? 15.233  -3.386  56.081  1.000 15.142 0 407 SO4 A O2  1 ? 
HETATM 2544 O  O3  . SO4 H 4 .   ? 13.751  -3.249  57.876  1.000 20.626 0 407 SO4 A O3  1 ? 
HETATM 2545 O  O4  . SO4 H 4 .   ? 15.986  -3.990  58.230  1.000 21.017 0 407 SO4 A O4  1 ? 
HETATM 2546 S  S   . SO4 I 4 .   ? 11.133  -8.725  52.533  1.000 56.921 0 408 SO4 A S   1 ? 
HETATM 2547 O  O1  . SO4 I 4 .   ? 11.504  -10.083 52.199  1.000 45.513 0 408 SO4 A O1  1 ? 
HETATM 2548 O  O2  . SO4 I 4 .   ? 11.417  -7.864  51.386  1.000 34.539 0 408 SO4 A O2  1 ? 
HETATM 2549 O  O3  . SO4 I 4 .   ? 9.715   -8.696  52.864  1.000 41.700 0 408 SO4 A O3  1 ? 
HETATM 2550 O  O4  . SO4 I 4 .   ? 11.914  -8.304  53.689  1.000 46.917 0 408 SO4 A O4  1 ? 
HETATM 2551 S  S   . SO4 J 4 .   ? 1.352   23.097  35.010  1.000 22.703 0 409 SO4 A S   1 ? 
HETATM 2552 O  O1  . SO4 J 4 .   ? 0.535   22.250  34.171  1.000 25.244 0 409 SO4 A O1  1 ? 
HETATM 2553 O  O2  . SO4 J 4 .   ? 1.064   24.488  34.771  1.000 23.318 0 409 SO4 A O2  1 ? 
HETATM 2554 O  O3  . SO4 J 4 .   ? 1.175   22.800  36.446  1.000 23.590 0 409 SO4 A O3  1 ? 
HETATM 2555 O  O4  . SO4 J 4 .   ? 2.747   22.820  34.650  1.000 28.137 0 409 SO4 A O4  1 ? 
HETATM 2556 S  S   . SO4 K 4 .   ? 22.522  -11.431 19.992  1.000 14.829 0 410 SO4 A S   1 ? 
HETATM 2557 O  O1  . SO4 K 4 .   ? 23.796  -11.886 19.431  1.000 16.332 0 410 SO4 A O1  1 ? 
HETATM 2558 O  O2  . SO4 K 4 .   ? 22.304  -10.086 19.489  1.000 14.876 0 410 SO4 A O2  1 ? 
HETATM 2559 O  O3  . SO4 K 4 .   ? 21.460  -12.288 19.601  1.000 14.675 0 410 SO4 A O3  1 ? 
HETATM 2560 O  O4  . SO4 K 4 .   ? 22.623  -11.412 21.445  1.000 14.899 0 410 SO4 A O4  1 ? 
HETATM 2561 S  S   . SO4 L 4 .   ? 15.303  -13.956 19.227  1.000 20.531 0 411 SO4 A S   1 ? 
HETATM 2562 O  O1  . SO4 L 4 .   ? 16.719  -14.015 19.464  1.000 22.562 0 411 SO4 A O1  1 ? 
HETATM 2563 O  O2  . SO4 L 4 .   ? 14.925  -12.860 18.408  1.000 28.646 0 411 SO4 A O2  1 ? 
HETATM 2564 O  O3  . SO4 L 4 .   ? 14.857  -15.196 18.543  1.000 22.037 0 411 SO4 A O3  1 ? 
HETATM 2565 O  O4  . SO4 L 4 .   ? 14.740  -13.876 20.563  1.000 24.414 0 411 SO4 A O4  1 ? 
HETATM 2566 S  S   . SO4 M 4 .   ? 39.629  8.841   22.398  1.000 46.021 0 412 SO4 A S   1 ? 
HETATM 2567 O  O1  . SO4 M 4 .   ? 40.411  7.628   22.327  1.000 52.349 0 412 SO4 A O1  1 ? 
HETATM 2568 O  O2  . SO4 M 4 .   ? 39.469  9.405   21.071  1.000 39.834 0 412 SO4 A O2  1 ? 
HETATM 2569 O  O3  . SO4 M 4 .   ? 38.332  8.523   22.937  1.000 52.682 0 412 SO4 A O3  1 ? 
HETATM 2570 O  O4  . SO4 M 4 .   ? 40.310  9.779   23.260  1.000 41.128 0 412 SO4 A O4  1 ? 
HETATM 2571 O  O   . HOH N 5 .   ? -1.873  22.477  32.773  1.000 25.712 0 501 HOH A O   1 ? 
HETATM 2572 O  O   . HOH N 5 .   ? 9.133   -8.001  38.118  1.000 11.583 0 502 HOH A O   1 ? 
HETATM 2573 O  O   . HOH N 5 .   ? 9.119   24.383  3.977   1.000 23.350 0 503 HOH A O   1 ? 
HETATM 2574 O  O   . HOH N 5 .   ? -9.097  16.747  33.902  1.000 18.584 0 504 HOH A O   1 ? 
HETATM 2575 O  O   . HOH N 5 .   ? 4.299   20.941  34.963  1.000 26.391 0 505 HOH A O   1 ? 
HETATM 2576 O  O   . HOH N 5 .   ? 15.451  -1.101  6.571   1.000 25.555 0 506 HOH A O   1 ? 
HETATM 2577 O  O   . HOH N 5 .   ? 7.828   7.555   0.113   1.000 19.392 0 507 HOH A O   1 ? 
HETATM 2578 O  O   . HOH N 5 .   ? 30.811  7.957   8.943   1.000 24.852 0 508 HOH A O   1 ? 
HETATM 2579 O  O   . HOH N 5 .   ? 17.037  3.927   -0.738  1.000 29.918 0 509 HOH A O   1 ? 
HETATM 2580 O  O   . HOH N 5 .   ? 14.056  17.078  -4.355  1.000 16.215 0 510 HOH A O   1 ? 
HETATM 2581 O  O   . HOH N 5 .   ? 11.442  -3.845  12.688  1.000 30.585 0 511 HOH A O   1 ? 
HETATM 2582 O  O   . HOH N 5 .   ? 29.148  31.682  0.504   1.000 20.322 0 512 HOH A O   1 ? 
HETATM 2583 O  O   . HOH N 5 .   ? 16.088  -0.700  27.971  1.000 21.346 0 513 HOH A O   1 ? 
HETATM 2584 O  O   . HOH N 5 .   ? 5.838   8.445   2.614   1.000 28.267 0 514 HOH A O   1 ? 
HETATM 2585 O  O   . HOH N 5 .   ? 30.494  1.042   30.858  1.000 26.010 0 515 HOH A O   1 ? 
HETATM 2586 O  O   . HOH N 5 .   ? 18.900  -0.497  33.825  1.000 29.189 0 516 HOH A O   1 ? 
HETATM 2587 O  O   . HOH N 5 .   ? 16.849  -3.748  9.520   1.000 24.141 0 517 HOH A O   1 ? 
HETATM 2588 O  O   . HOH N 5 .   ? 14.533  5.439   -0.568  1.000 16.268 0 518 HOH A O   1 ? 
HETATM 2589 O  O   . HOH N 5 .   ? 14.798  7.898   57.312  1.000 20.127 0 519 HOH A O   1 ? 
HETATM 2590 O  O   . HOH N 5 .   ? 15.063  -8.500  45.866  1.000 28.675 0 520 HOH A O   1 ? 
HETATM 2591 O  O   . HOH N 5 .   ? 9.873   4.358   17.978  1.000 18.924 0 521 HOH A O   1 ? 
HETATM 2592 O  O   . HOH N 5 .   ? 32.436  3.829   8.757   1.000 27.292 0 522 HOH A O   1 ? 
HETATM 2593 O  O   . HOH N 5 .   ? -4.234  21.077  29.977  1.000 22.732 0 523 HOH A O   1 ? 
HETATM 2594 O  O   . HOH N 5 .   ? 24.234  -4.395  4.110   1.000 20.327 0 524 HOH A O   1 ? 
HETATM 2595 O  O   . HOH N 5 .   ? 22.605  -9.130  14.403  1.000 14.218 0 525 HOH A O   1 ? 
HETATM 2596 O  O   . HOH N 5 .   ? 11.658  23.597  33.341  1.000 22.823 0 526 HOH A O   1 ? 
HETATM 2597 O  O   . HOH N 5 .   ? 13.262  12.046  58.164  1.000 21.992 0 527 HOH A O   1 ? 
HETATM 2598 O  O   . HOH N 5 .   ? 29.029  -7.195  16.767  1.000 28.177 0 528 HOH A O   1 ? 
HETATM 2599 O  O   . HOH N 5 .   ? 29.832  19.833  5.260   1.000 18.908 0 529 HOH A O   1 ? 
HETATM 2600 O  O   . HOH N 5 .   ? -8.013  11.183  28.157  1.000 28.610 0 530 HOH A O   1 ? 
HETATM 2601 O  O   . HOH N 5 .   ? 34.843  0.316   18.141  1.000 27.645 0 531 HOH A O   1 ? 
HETATM 2602 O  O   . HOH N 5 .   ? 31.630  33.624  4.555   1.000 21.892 0 532 HOH A O   1 ? 
HETATM 2603 O  O   . HOH N 5 .   ? 12.791  11.197  -7.783  1.000 20.786 0 533 HOH A O   1 ? 
HETATM 2604 O  O   . HOH N 5 .   ? 13.393  -2.069  20.725  1.000 16.096 0 534 HOH A O   1 ? 
HETATM 2605 O  O   . HOH N 5 .   ? 14.306  6.766   -4.034  1.000 24.167 0 535 HOH A O   1 ? 
HETATM 2606 O  O   . HOH N 5 .   ? 29.759  4.856   17.103  1.000 17.332 0 536 HOH A O   1 ? 
HETATM 2607 O  O   . HOH N 5 .   ? 14.269  -10.285 18.306  1.000 28.913 0 537 HOH A O   1 ? 
HETATM 2608 O  O   . HOH N 5 .   ? 9.928   1.664   17.011  1.000 19.631 0 538 HOH A O   1 ? 
HETATM 2609 O  O   . HOH N 5 .   ? 5.918   16.397  37.747  1.000 26.857 0 539 HOH A O   1 ? 
HETATM 2610 O  O   . HOH N 5 .   ? 31.459  26.315  4.255   1.000 16.284 0 540 HOH A O   1 ? 
HETATM 2611 O  O   . HOH N 5 .   ? 24.707  -10.953 17.100  1.000 14.718 0 541 HOH A O   1 ? 
HETATM 2612 O  O   . HOH N 5 .   ? 15.311  -17.769 19.106  1.000 19.500 0 542 HOH A O   1 ? 
HETATM 2613 O  O   . HOH N 5 .   ? 30.163  16.986  15.251  1.000 16.204 0 543 HOH A O   1 ? 
HETATM 2614 O  O   . HOH N 5 .   ? 21.442  -4.683  27.813  1.000 16.956 0 544 HOH A O   1 ? 
HETATM 2615 O  O   . HOH N 5 .   ? 15.096  -8.860  41.117  1.000 21.467 0 545 HOH A O   1 ? 
HETATM 2616 O  O   . HOH N 5 .   ? 19.564  15.364  13.616  1.000 20.137 0 546 HOH A O   1 ? 
HETATM 2617 O  O   . HOH N 5 .   ? 11.647  25.755  5.710   1.000 15.887 0 547 HOH A O   1 ? 
HETATM 2618 O  O   . HOH N 5 .   ? 25.012  -14.207 20.022  1.000 22.919 0 548 HOH A O   1 ? 
HETATM 2619 O  O   . HOH N 5 .   ? 13.513  10.143  33.536  1.000 19.135 0 549 HOH A O   1 ? 
HETATM 2620 O  O   . HOH N 5 .   ? 17.723  34.573  3.409   1.000 27.685 0 550 HOH A O   1 ? 
HETATM 2621 O  O   . HOH N 5 .   ? 27.242  27.336  6.097   1.000 12.272 0 551 HOH A O   1 ? 
HETATM 2622 O  O   . HOH N 5 .   ? 4.959   14.291  -0.610  1.000 21.709 0 552 HOH A O   1 ? 
HETATM 2623 O  O   . HOH N 5 .   ? 25.835  17.214  24.358  1.000 19.684 0 553 HOH A O   1 ? 
HETATM 2624 O  O   . HOH N 5 .   ? -0.686  18.584  13.211  1.000 29.761 0 554 HOH A O   1 ? 
HETATM 2625 O  O   . HOH N 5 .   ? 22.091  -8.718  17.122  1.000 14.462 0 555 HOH A O   1 ? 
HETATM 2626 O  O   . HOH N 5 .   ? 17.806  20.998  16.991  1.000 18.643 0 556 HOH A O   1 ? 
HETATM 2627 O  O   . HOH N 5 .   ? 14.515  9.266   23.091  1.000 11.805 0 557 HOH A O   1 ? 
HETATM 2628 O  O   . HOH N 5 .   ? 29.474  11.744  10.866  1.000 10.991 0 558 HOH A O   1 ? 
HETATM 2629 O  O   . HOH N 5 .   ? 9.936   -9.036  46.405  1.000 30.310 0 559 HOH A O   1 ? 
HETATM 2630 O  O   . HOH N 5 .   ? 20.309  34.705  7.146   1.000 12.310 0 560 HOH A O   1 ? 
HETATM 2631 O  O   . HOH N 5 .   ? 24.851  4.824   39.544  1.000 22.999 0 561 HOH A O   1 ? 
HETATM 2632 O  O   . HOH N 5 .   ? 19.143  27.556  -4.592  1.000 18.050 0 562 HOH A O   1 ? 
HETATM 2633 O  O   . HOH N 5 .   ? 26.747  -4.901  5.919   1.000 30.811 0 563 HOH A O   1 ? 
HETATM 2634 O  O   . HOH N 5 .   ? 28.470  12.513  1.816   1.000 27.593 0 564 HOH A O   1 ? 
HETATM 2635 O  O   . HOH N 5 .   ? 18.017  10.771  32.060  1.000 19.294 0 565 HOH A O   1 ? 
HETATM 2636 O  O   . HOH N 5 .   ? 16.017  16.886  54.086  1.000 26.515 0 566 HOH A O   1 ? 
HETATM 2637 O  O   . HOH N 5 .   ? 25.211  18.447  16.014  1.000 25.965 0 567 HOH A O   1 ? 
HETATM 2638 O  O   . HOH N 5 .   ? 27.870  23.128  7.333   1.000 10.910 0 568 HOH A O   1 ? 
HETATM 2639 O  O   . HOH N 5 .   ? 35.159  -3.501  15.392  1.000 26.995 0 569 HOH A O   1 ? 
HETATM 2640 O  O   . HOH N 5 .   ? 30.644  5.204   14.366  1.000 19.323 0 570 HOH A O   1 ? 
HETATM 2641 O  O   . HOH N 5 .   ? -3.853  5.587   37.181  1.000 12.411 0 571 HOH A O   1 ? 
HETATM 2642 O  O   . HOH N 5 .   ? 27.696  5.275   50.720  1.000 22.433 0 572 HOH A O   1 ? 
HETATM 2643 O  O   . HOH N 5 .   ? 15.870  8.979   33.885  1.000 17.371 0 573 HOH A O   1 ? 
HETATM 2644 O  O   . HOH N 5 .   ? 25.548  37.097  0.058   1.000 24.997 0 574 HOH A O   1 ? 
HETATM 2645 O  O   . HOH N 5 .   ? 16.445  31.125  5.974   1.000 23.273 0 575 HOH A O   1 ? 
HETATM 2646 O  O   . HOH N 5 .   ? 11.296  9.101   13.752  1.000 14.075 0 576 HOH A O   1 ? 
HETATM 2647 O  O   . HOH N 5 .   ? 29.001  11.079  7.104   1.000 21.823 0 577 HOH A O   1 ? 
HETATM 2648 O  O   . HOH N 5 .   ? 26.630  14.768  -2.224  1.000 27.323 0 578 HOH A O   1 ? 
HETATM 2649 O  O   . HOH N 5 .   ? 26.155  7.778   44.314  1.000 21.563 0 579 HOH A O   1 ? 
HETATM 2650 O  O   . HOH N 5 .   ? 29.625  -9.648  23.001  1.000 19.336 0 580 HOH A O   1 ? 
HETATM 2651 O  O   . HOH N 5 .   ? 16.773  5.605   25.525  1.000 22.449 0 581 HOH A O   1 ? 
HETATM 2652 O  O   . HOH N 5 .   ? 8.843   21.370  -7.273  1.000 34.767 0 582 HOH A O   1 ? 
HETATM 2653 O  O   . HOH N 5 .   ? 23.191  -5.527  19.405  1.000 15.384 0 583 HOH A O   1 ? 
HETATM 2654 O  O   . HOH N 5 .   ? 21.387  -6.906  54.264  1.000 12.124 0 584 HOH A O   1 ? 
HETATM 2655 O  O   . HOH N 5 .   ? 20.079  2.145   58.007  1.000 18.816 0 585 HOH A O   1 ? 
HETATM 2656 O  O   . HOH N 5 .   ? 4.817   4.582   17.743  1.000 15.778 0 586 HOH A O   1 ? 
HETATM 2657 O  O   . HOH N 5 .   ? 32.673  18.308  10.196  1.000 30.885 0 587 HOH A O   1 ? 
HETATM 2658 O  O   . HOH N 5 .   ? 10.941  9.719   11.100  1.000 16.031 0 588 HOH A O   1 ? 
HETATM 2659 O  O   . HOH N 5 .   ? 15.555  -7.202  22.047  1.000 20.464 0 589 HOH A O   1 ? 
HETATM 2660 O  O   . HOH N 5 .   ? 8.837   17.190  -4.619  1.000 25.536 0 590 HOH A O   1 ? 
HETATM 2661 O  O   . HOH N 5 .   ? 1.059   25.342  22.943  1.000 23.331 0 591 HOH A O   1 ? 
HETATM 2662 O  O   . HOH N 5 .   ? 10.437  24.850  21.603  1.000 26.993 0 592 HOH A O   1 ? 
HETATM 2663 O  O   . HOH N 5 .   ? 32.340  -9.012  19.870  1.000 12.745 0 593 HOH A O   1 ? 
HETATM 2664 O  O   . HOH N 5 .   ? 21.129  -14.000 17.474  1.000 16.305 0 594 HOH A O   1 ? 
HETATM 2665 O  O   . HOH N 5 .   ? 9.197   13.372  47.293  1.000 23.479 0 595 HOH A O   1 ? 
HETATM 2666 O  O   . HOH N 5 .   ? 18.751  8.439   28.195  1.000 12.734 0 596 HOH A O   1 ? 
HETATM 2667 O  O   . HOH N 5 .   ? 2.428   -6.179  54.064  1.000 18.561 0 597 HOH A O   1 ? 
HETATM 2668 O  O   . HOH N 5 .   ? 16.100  31.402  1.037   1.000 18.260 0 598 HOH A O   1 ? 
HETATM 2669 O  O   . HOH N 5 .   ? 1.767   14.103  13.220  1.000 23.381 0 599 HOH A O   1 ? 
HETATM 2670 O  O   . HOH N 5 .   ? 11.667  9.994   51.610  1.000 12.005 0 600 HOH A O   1 ? 
HETATM 2671 O  O   . HOH N 5 .   ? 17.140  6.999   32.518  1.000 11.225 0 601 HOH A O   1 ? 
HETATM 2672 O  O   . HOH N 5 .   ? 18.112  4.421   54.989  1.000 13.992 0 602 HOH A O   1 ? 
HETATM 2673 O  O   . HOH N 5 .   ? 8.048   18.522  9.786   1.000 24.626 0 603 HOH A O   1 ? 
HETATM 2674 O  O   . HOH N 5 .   ? 8.408   0.266   19.697  1.000 17.437 0 604 HOH A O   1 ? 
HETATM 2675 O  O   . HOH N 5 .   ? 28.288  5.556   30.695  1.000 22.173 0 605 HOH A O   1 ? 
HETATM 2676 O  O   . HOH N 5 .   ? 13.860  12.043  35.270  1.000 15.274 0 606 HOH A O   1 ? 
HETATM 2677 O  O   . HOH N 5 .   ? 11.613  6.637   14.812  1.000 19.175 0 607 HOH A O   1 ? 
HETATM 2678 O  O   . HOH N 5 .   ? 5.173   22.486  16.705  1.000 22.869 0 608 HOH A O   1 ? 
HETATM 2679 O  O   . HOH N 5 .   ? 18.639  -6.780  10.263  1.000 18.550 0 609 HOH A O   1 ? 
HETATM 2680 O  O   . HOH N 5 .   ? 11.327  -6.612  48.787  1.000 18.473 0 610 HOH A O   1 ? 
HETATM 2681 O  O   . HOH N 5 .   ? 21.815  17.002  -7.663  1.000 19.050 0 611 HOH A O   1 ? 
HETATM 2682 O  O   . HOH N 5 .   ? 15.681  -6.626  18.572  1.000 19.387 0 612 HOH A O   1 ? 
HETATM 2683 O  O   . HOH N 5 .   ? 14.666  20.481  22.942  1.000 22.892 0 613 HOH A O   1 ? 
HETATM 2684 O  O   . HOH N 5 .   ? 25.684  12.670  15.330  1.000 11.227 0 614 HOH A O   1 ? 
HETATM 2685 O  O   . HOH N 5 .   ? -5.642  2.315   22.708  1.000 47.268 0 615 HOH A O   1 ? 
HETATM 2686 O  O   . HOH N 5 .   ? 24.264  25.700  13.825  1.000 10.760 0 616 HOH A O   1 ? 
HETATM 2687 O  O   . HOH N 5 .   ? 18.608  32.969  -1.538  1.000 18.361 0 617 HOH A O   1 ? 
HETATM 2688 O  O   . HOH N 5 .   ? -9.257  19.909  20.084  1.000 17.436 0 618 HOH A O   1 ? 
HETATM 2689 O  O   . HOH N 5 .   ? 10.834  1.485   20.371  1.000 14.439 0 619 HOH A O   1 ? 
HETATM 2690 O  O   . HOH N 5 .   ? 0.156   10.877  38.777  1.000 20.770 0 620 HOH A O   1 ? 
HETATM 2691 O  O   . HOH N 5 .   ? 22.868  13.168  15.897  1.000 10.043 0 621 HOH A O   1 ? 
HETATM 2692 O  O   . HOH N 5 .   ? 24.756  15.561  14.434  1.000 24.552 0 622 HOH A O   1 ? 
HETATM 2693 O  O   . HOH N 5 .   ? 12.361  1.338   28.255  1.000 13.579 0 623 HOH A O   1 ? 
HETATM 2694 O  O   . HOH N 5 .   ? 11.938  17.414  42.273  1.000 20.999 0 624 HOH A O   1 ? 
HETATM 2695 O  O   . HOH N 5 .   ? -7.117  4.954   30.426  1.000 29.521 0 625 HOH A O   1 ? 
HETATM 2696 O  O   . HOH N 5 .   ? 24.409  8.325   48.396  1.000 15.928 0 626 HOH A O   1 ? 
HETATM 2697 O  O   . HOH N 5 .   ? 11.549  1.241   25.446  1.000 11.780 0 627 HOH A O   1 ? 
HETATM 2698 O  O   . HOH N 5 .   ? 24.598  11.138  41.083  1.000 15.510 0 628 HOH A O   1 ? 
HETATM 2699 O  O   . HOH N 5 .   ? 30.215  11.435  18.348  1.000 11.571 0 629 HOH A O   1 ? 
HETATM 2700 O  O   . HOH N 5 .   ? 14.824  -0.529  22.473  1.000 15.831 0 630 HOH A O   1 ? 
HETATM 2701 O  O   . HOH N 5 .   ? 30.544  8.728   18.160  1.000 13.194 0 631 HOH A O   1 ? 
HETATM 2702 O  O   . HOH N 5 .   ? 18.287  19.061  47.853  1.000 11.847 0 632 HOH A O   1 ? 
HETATM 2703 O  O   . HOH N 5 .   ? -8.862  15.872  31.184  1.000 21.647 0 633 HOH A O   1 ? 
HETATM 2704 O  O   . HOH N 5 .   ? 25.848  -2.388  52.918  1.000 13.527 0 634 HOH A O   1 ? 
HETATM 2705 O  O   . HOH N 5 .   ? 18.994  27.656  -7.186  1.000 26.084 0 635 HOH A O   1 ? 
HETATM 2706 O  O   . HOH N 5 .   ? 25.863  12.903  10.818  1.000 11.204 0 636 HOH A O   1 ? 
HETATM 2707 O  O   . HOH N 5 .   ? 25.827  28.830  -5.183  1.000 19.572 0 637 HOH A O   1 ? 
HETATM 2708 O  O   . HOH N 5 .   ? 14.845  12.801  31.492  1.000 19.499 0 638 HOH A O   1 ? 
HETATM 2709 O  O   . HOH N 5 .   ? 12.748  25.727  16.841  1.000 20.226 0 639 HOH A O   1 ? 
HETATM 2710 O  O   . HOH N 5 .   ? -5.422  15.336  18.212  1.000 21.874 0 640 HOH A O   1 ? 
HETATM 2711 O  O   . HOH N 5 .   ? 21.833  -2.234  40.959  1.000 28.631 0 641 HOH A O   1 ? 
HETATM 2712 O  O   . HOH N 5 .   ? 32.673  18.355  13.365  1.000 26.639 0 642 HOH A O   1 ? 
HETATM 2713 O  O   . HOH N 5 .   ? 22.078  10.724  25.984  1.000 26.667 0 643 HOH A O   1 ? 
HETATM 2714 O  O   . HOH N 5 .   ? 24.760  19.072  -2.121  1.000 25.173 0 644 HOH A O   1 ? 
HETATM 2715 O  O   . HOH N 5 .   ? 17.549  -4.683  55.147  1.000 14.707 0 645 HOH A O   1 ? 
HETATM 2716 O  O   . HOH N 5 .   ? 34.773  1.858   25.435  1.000 18.125 0 646 HOH A O   1 ? 
HETATM 2717 O  O   . HOH N 5 .   ? 11.474  23.276  3.324   1.000 11.661 0 647 HOH A O   1 ? 
HETATM 2718 O  O   . HOH N 5 .   ? 26.562  21.554  -2.765  1.000 21.358 0 648 HOH A O   1 ? 
HETATM 2719 O  O   . HOH N 5 .   ? 13.438  -0.327  31.782  1.000 18.695 0 649 HOH A O   1 ? 
HETATM 2720 O  O   . HOH N 5 .   ? 12.086  -1.305  56.692  1.000 26.631 0 650 HOH A O   1 ? 
HETATM 2721 O  O   . HOH N 5 .   ? 0.226   19.492  26.110  1.000 11.785 0 651 HOH A O   1 ? 
HETATM 2722 O  O   . HOH N 5 .   ? 13.684  0.481   4.505   1.000 23.452 0 652 HOH A O   1 ? 
HETATM 2723 O  O   . HOH N 5 .   ? 14.103  26.837  8.277   1.000 21.327 0 653 HOH A O   1 ? 
HETATM 2724 O  O   . HOH N 5 .   ? 24.261  -2.810  29.829  1.000 26.008 0 654 HOH A O   1 ? 
HETATM 2725 O  O   . HOH N 5 .   ? 12.690  -4.302  49.701  1.000 11.476 0 655 HOH A O   1 ? 
HETATM 2726 O  O   . HOH N 5 .   ? 32.750  14.716  16.878  1.000 15.255 0 656 HOH A O   1 ? 
HETATM 2727 O  O   . HOH N 5 .   ? 14.541  13.467  50.141  1.000 11.916 0 657 HOH A O   1 ? 
HETATM 2728 O  O   . HOH N 5 .   ? 8.814   -4.913  32.539  1.000 25.376 0 658 HOH A O   1 ? 
HETATM 2729 O  O   . HOH N 5 .   ? 17.303  30.516  3.355   1.000 19.727 0 659 HOH A O   1 ? 
HETATM 2730 O  O   . HOH N 5 .   ? 27.396  23.628  17.073  1.000 16.554 0 660 HOH A O   1 ? 
HETATM 2731 O  O   . HOH N 5 .   ? 6.071   7.024   17.667  1.000 12.558 0 661 HOH A O   1 ? 
HETATM 2732 O  O   . HOH N 5 .   ? 29.087  -6.100  30.998  1.000 18.402 0 662 HOH A O   1 ? 
HETATM 2733 O  O   . HOH N 5 .   ? -0.824  3.816   18.553  1.000 27.931 0 663 HOH A O   1 ? 
HETATM 2734 O  O   . HOH N 5 .   ? 12.520  25.759  13.014  1.000 17.866 0 664 HOH A O   1 ? 
HETATM 2735 O  O   . HOH N 5 .   ? 19.223  -3.928  26.556  1.000 13.359 0 665 HOH A O   1 ? 
HETATM 2736 O  O   . HOH N 5 .   ? 19.367  31.281  12.145  1.000 20.177 0 666 HOH A O   1 ? 
HETATM 2737 O  O   . HOH N 5 .   ? 4.231   23.558  28.517  1.000 23.367 0 667 HOH A O   1 ? 
HETATM 2738 O  O   . HOH N 5 .   ? 30.080  24.528  10.248  1.000 20.781 0 668 HOH A O   1 ? 
HETATM 2739 O  O   . HOH N 5 .   ? 31.571  -4.689  30.869  1.000 19.232 0 669 HOH A O   1 ? 
HETATM 2740 O  O   . HOH N 5 .   ? 33.248  4.397   20.261  1.000 26.911 0 670 HOH A O   1 ? 
HETATM 2741 O  O   . HOH N 5 .   ? 19.992  14.091  36.398  1.000 15.690 0 671 HOH A O   1 ? 
HETATM 2742 O  O   . HOH N 5 .   ? 3.429   -9.950  47.838  1.000 29.057 0 672 HOH A O   1 ? 
HETATM 2743 O  O   . HOH N 5 .   ? 27.296  -0.459  54.423  1.000 17.286 0 673 HOH A O   1 ? 
HETATM 2744 O  O   . HOH N 5 .   ? 13.460  21.739  20.957  1.000 24.490 0 674 HOH A O   1 ? 
HETATM 2745 O  O   . HOH N 5 .   ? -0.990  -1.981  22.258  1.000 33.822 0 675 HOH A O   1 ? 
HETATM 2746 O  O   . HOH N 5 .   ? 23.504  1.116   36.490  1.000 24.234 0 676 HOH A O   1 ? 
HETATM 2747 O  O   . HOH N 5 .   ? 23.502  8.546   -6.599  1.000 27.044 0 677 HOH A O   1 ? 
HETATM 2748 O  O   . HOH N 5 .   ? 7.924   3.888   2.506   1.000 26.213 0 678 HOH A O   1 ? 
HETATM 2749 O  O   . HOH N 5 .   ? 11.871  19.866  45.590  1.000 27.529 0 679 HOH A O   1 ? 
HETATM 2750 O  O   . HOH N 5 .   ? 15.030  22.210  32.369  1.000 30.539 0 680 HOH A O   1 ? 
HETATM 2751 O  O   . HOH N 5 .   ? 31.034  1.227   19.963  1.000 10.662 0 681 HOH A O   1 ? 
HETATM 2752 O  O   . HOH N 5 .   ? 7.032   4.121   52.130  1.000 11.968 0 682 HOH A O   1 ? 
HETATM 2753 O  O   . HOH N 5 .   ? 14.567  3.131   0.716   1.000 27.514 0 683 HOH A O   1 ? 
HETATM 2754 O  O   . HOH N 5 .   ? 12.392  25.562  10.209  1.000 19.266 0 684 HOH A O   1 ? 
HETATM 2755 O  O   . HOH N 5 .   ? 12.305  33.788  -4.960  1.000 34.174 0 685 HOH A O   1 ? 
HETATM 2756 O  O   . HOH N 5 .   ? 22.285  -0.062  42.759  1.000 25.064 0 686 HOH A O   1 ? 
HETATM 2757 O  O   . HOH N 5 .   ? 30.788  22.801  -6.078  1.000 21.164 0 687 HOH A O   1 ? 
HETATM 2758 O  O   . HOH N 5 .   ? 20.987  0.045   45.113  1.000 12.297 0 688 HOH A O   1 ? 
HETATM 2759 O  O   . HOH N 5 .   ? 25.363  31.303  -5.565  1.000 29.429 0 689 HOH A O   1 ? 
HETATM 2760 O  O   . HOH N 5 .   ? 4.857   2.535   52.346  1.000 20.925 0 690 HOH A O   1 ? 
HETATM 2761 O  O   . HOH N 5 .   ? 18.179  -1.696  6.218   1.000 16.399 0 691 HOH A O   1 ? 
HETATM 2762 O  O   . HOH N 5 .   ? 26.916  1.867   48.364  1.000 18.737 0 692 HOH A O   1 ? 
HETATM 2763 O  O   . HOH N 5 .   ? 24.647  -2.121  2.598   1.000 17.970 0 693 HOH A O   1 ? 
HETATM 2764 O  O   . HOH N 5 .   ? 1.822   15.775  36.974  1.000 25.801 0 694 HOH A O   1 ? 
HETATM 2765 O  O   . HOH N 5 .   ? 35.222  -3.506  18.120  1.000 17.992 0 695 HOH A O   1 ? 
HETATM 2766 O  O   . HOH N 5 .   ? 12.645  17.817  -7.007  1.000 23.997 0 696 HOH A O   1 ? 
HETATM 2767 O  O   . HOH N 5 .   ? 20.604  -2.217  57.036  1.000 21.096 0 697 HOH A O   1 ? 
HETATM 2768 O  O   . HOH N 5 .   ? 8.793   5.247   5.246   1.000 23.947 0 698 HOH A O   1 ? 
HETATM 2769 O  O   . HOH N 5 .   ? 8.224   -8.587  49.726  1.000 18.906 0 699 HOH A O   1 ? 
HETATM 2770 O  O   . HOH N 5 .   ? 8.271   12.484  14.816  1.000 19.896 0 700 HOH A O   1 ? 
HETATM 2771 O  O   . HOH N 5 .   ? 10.053  19.667  14.037  1.000 15.903 0 701 HOH A O   1 ? 
HETATM 2772 O  O   . HOH N 5 .   ? 15.285  2.379   3.343   1.000 14.848 0 702 HOH A O   1 ? 
HETATM 2773 O  O   . HOH N 5 .   ? 31.458  12.778  24.803  1.000 22.644 0 703 HOH A O   1 ? 
HETATM 2774 O  O   . HOH N 5 .   ? 6.540   16.158  -3.687  1.000 31.736 0 704 HOH A O   1 ? 
HETATM 2775 O  O   . HOH N 5 .   ? 5.811   -1.275  22.360  1.000 22.259 0 705 HOH A O   1 ? 
HETATM 2776 O  O   . HOH N 5 .   ? 18.226  9.334   -14.240 1.000 19.442 0 706 HOH A O   1 ? 
HETATM 2777 O  O   . HOH N 5 .   ? 32.726  21.954  12.682  1.000 18.866 0 707 HOH A O   1 ? 
HETATM 2778 O  O   . HOH N 5 .   ? 28.687  13.848  9.214   1.000 13.503 0 708 HOH A O   1 ? 
HETATM 2779 O  O   . HOH N 5 .   ? 22.301  15.081  13.845  1.000 15.611 0 709 HOH A O   1 ? 
HETATM 2780 O  O   . HOH N 5 .   ? 26.644  -10.264 22.768  1.000 20.069 0 710 HOH A O   1 ? 
HETATM 2781 O  O   . HOH N 5 .   ? 10.579  17.629  39.781  1.000 20.084 0 711 HOH A O   1 ? 
HETATM 2782 O  O   . HOH N 5 .   ? 25.441  0.828   3.036   1.000 22.487 0 712 HOH A O   1 ? 
HETATM 2783 O  O   . HOH N 5 .   ? 17.117  -7.222  54.236  1.000 15.253 0 713 HOH A O   1 ? 
HETATM 2784 O  O   . HOH N 5 .   ? 31.504  -5.723  17.088  1.000 15.559 0 714 HOH A O   1 ? 
HETATM 2785 O  O   . HOH N 5 .   ? 24.720  8.845   32.395  1.000 18.094 0 715 HOH A O   1 ? 
HETATM 2786 O  O   . HOH N 5 .   ? 21.065  7.322   -5.168  1.000 23.734 0 716 HOH A O   1 ? 
HETATM 2787 O  O   . HOH N 5 .   ? 17.813  17.660  36.381  1.000 25.466 0 717 HOH A O   1 ? 
HETATM 2788 O  O   . HOH N 5 .   ? 29.949  29.280  15.288  1.000 27.010 0 718 HOH A O   1 ? 
HETATM 2789 O  O   . HOH N 5 .   ? 21.348  17.047  40.464  1.000 21.238 0 719 HOH A O   1 ? 
HETATM 2790 O  O   . HOH N 5 .   ? 25.313  21.640  13.771  1.000 12.687 0 720 HOH A O   1 ? 
HETATM 2791 O  O   . HOH N 5 .   ? 31.078  2.197   17.292  1.000 14.089 0 721 HOH A O   1 ? 
HETATM 2792 O  O   . HOH N 5 .   ? 18.473  -6.829  47.316  1.000 18.744 0 722 HOH A O   1 ? 
HETATM 2793 O  O   . HOH N 5 .   ? 13.357  15.729  48.720  1.000 20.759 0 723 HOH A O   1 ? 
HETATM 2794 O  O   . HOH N 5 .   ? 18.004  1.934   2.701   1.000 15.422 0 724 HOH A O   1 ? 
HETATM 2795 O  O   . HOH N 5 .   ? 17.335  -8.419  39.286  1.000 29.813 0 725 HOH A O   1 ? 
HETATM 2796 O  O   . HOH N 5 .   ? 17.599  22.146  50.061  1.000 24.944 0 726 HOH A O   1 ? 
HETATM 2797 O  O   . HOH N 5 .   ? -6.502  5.242   21.541  1.000 24.857 0 727 HOH A O   1 ? 
HETATM 2798 O  O   . HOH N 5 .   ? 23.506  -6.387  16.614  1.000 15.891 0 728 HOH A O   1 ? 
HETATM 2799 O  O   . HOH N 5 .   ? 0.119   18.311  28.820  1.000 12.382 0 729 HOH A O   1 ? 
HETATM 2800 O  O   . HOH N 5 .   ? 31.170  6.997   28.035  1.000 27.837 0 730 HOH A O   1 ? 
HETATM 2801 O  O   . HOH N 5 .   ? 16.160  0.432   32.031  1.000 22.301 0 731 HOH A O   1 ? 
HETATM 2802 O  O   . HOH N 5 .   ? 0.187   2.075   46.128  1.000 28.076 0 732 HOH A O   1 ? 
HETATM 2803 O  O   . HOH N 5 .   ? 27.007  13.828  13.215  1.000 13.117 0 733 HOH A O   1 ? 
HETATM 2804 O  O   . HOH N 5 .   ? 17.587  -1.545  56.768  1.000 23.702 0 734 HOH A O   1 ? 
HETATM 2805 O  O   . HOH N 5 .   ? 9.641   -1.947  19.939  1.000 26.954 0 735 HOH A O   1 ? 
HETATM 2806 O  O   . HOH N 5 .   ? 24.758  10.245  26.246  1.000 20.644 0 736 HOH A O   1 ? 
HETATM 2807 O  O   . HOH N 5 .   ? 18.765  2.323   0.108   1.000 19.487 0 737 HOH A O   1 ? 
HETATM 2808 O  O   . HOH N 5 .   ? 32.231  5.953   10.386  1.000 24.424 0 738 HOH A O   1 ? 
HETATM 2809 O  O   . HOH N 5 .   ? 5.153   16.846  4.001   1.000 29.222 0 739 HOH A O   1 ? 
HETATM 2810 O  O   . HOH N 5 .   ? 17.769  -0.813  3.523   1.000 24.213 0 740 HOH A O   1 ? 
HETATM 2811 O  O   . HOH N 5 .   ? 23.558  -1.959  55.257  1.000 23.486 0 741 HOH A O   1 ? 
HETATM 2812 O  O   . HOH N 5 .   ? 21.128  11.764  56.046  1.000 27.418 0 742 HOH A O   1 ? 
HETATM 2813 O  O   . HOH N 5 .   ? 17.523  12.656  30.641  1.000 26.197 0 743 HOH A O   1 ? 
HETATM 2814 O  O   . HOH N 5 .   ? 28.759  0.756   52.165  1.000 30.573 0 744 HOH A O   1 ? 
HETATM 2815 O  O   . HOH N 5 .   ? 25.808  5.752   32.154  1.000 15.931 0 745 HOH A O   1 ? 
HETATM 2816 O  O   . HOH N 5 .   ? 13.373  -4.707  19.620  1.000 27.371 0 746 HOH A O   1 ? 
HETATM 2817 O  O   . HOH N 5 .   ? 5.888   -8.216  47.517  1.000 17.153 0 747 HOH A O   1 ? 
HETATM 2818 O  O   . HOH N 5 .   ? 27.370  -0.239  50.170  1.000 22.333 0 748 HOH A O   1 ? 
HETATM 2819 O  O   . HOH N 5 .   ? 18.738  -5.746  57.657  1.000 30.865 0 749 HOH A O   1 ? 
HETATM 2820 O  O   . HOH N 5 .   ? 8.027   17.188  14.221  1.000 26.894 0 750 HOH A O   1 ? 
HETATM 2821 O  O   . HOH N 5 .   ? 13.583  -0.771  29.163  1.000 19.850 0 751 HOH A O   1 ? 
HETATM 2822 O  O   . HOH N 5 .   ? 27.194  28.173  17.135  1.000 19.418 0 752 HOH A O   1 ? 
HETATM 2823 O  O   . HOH N 5 .   ? 24.999  23.577  15.696  1.000 18.199 0 753 HOH A O   1 ? 
HETATM 2824 O  O   . HOH N 5 .   ? 12.501  -3.356  28.719  1.000 31.755 0 754 HOH A O   1 ? 
HETATM 2825 O  O   . HOH N 5 .   ? 23.801  2.152   -0.488  1.000 27.045 0 755 HOH A O   1 ? 
HETATM 2826 O  O   . HOH N 5 .   ? 34.311  11.225  18.870  1.000 19.633 0 756 HOH A O   1 ? 
HETATM 2827 O  O   . HOH N 5 .   ? 25.502  6.793   50.500  1.000 23.697 0 757 HOH A O   1 ? 
HETATM 2828 O  O   . HOH N 5 .   ? -5.605  9.781   35.807  1.000 20.751 0 758 HOH A O   1 ? 
HETATM 2829 O  O   . HOH N 5 .   ? 26.169  8.916   41.861  1.000 22.154 0 759 HOH A O   1 ? 
HETATM 2830 O  O   . HOH N 5 .   ? 19.303  17.915  15.223  1.000 20.996 0 760 HOH A O   1 ? 
HETATM 2831 O  O   . HOH N 5 .   ? 18.968  -6.307  25.169  1.000 19.913 0 761 HOH A O   1 ? 
HETATM 2832 O  O   . HOH N 5 .   ? 21.828  16.067  36.704  1.000 25.453 0 762 HOH A O   1 ? 
HETATM 2833 O  O   . HOH N 5 .   ? -3.876  8.348   37.651  1.000 21.761 0 763 HOH A O   1 ? 
HETATM 2834 O  O   . HOH N 5 .   ? 29.096  30.151  17.569  1.000 27.108 0 764 HOH A O   1 ? 
HETATM 2835 O  O   . HOH N 5 .   ? 17.839  -4.415  6.738   1.000 20.066 0 765 HOH A O   1 ? 
HETATM 2836 O  O   . HOH N 5 .   ? 14.248  11.105  -22.558 1.000 26.790 0 766 HOH A O   1 ? 
HETATM 2837 O  O   . HOH N 5 .   ? 17.159  8.763   30.445  1.000 12.506 0 767 HOH A O   1 ? 
HETATM 2838 O  O   . HOH N 5 .   ? 17.632  3.281   57.438  1.000 17.700 0 768 HOH A O   1 ? 
HETATM 2839 O  O   . HOH N 5 .   ? 16.945  -3.494  27.890  1.000 25.678 0 769 HOH A O   1 ? 
HETATM 2840 O  O   . HOH N 5 .   ? 17.372  8.557   57.876  1.000 33.120 0 770 HOH A O   1 ? 
HETATM 2841 O  O   . HOH N 5 .   ? 31.492  10.500  9.494   1.000 22.875 0 771 HOH A O   1 ? 
HETATM 2842 O  O   . HOH N 5 .   ? 23.349  20.050  14.870  1.000 23.260 0 772 HOH A O   1 ? 
HETATM 2843 O  O   . HOH N 5 .   ? 27.459  25.680  18.837  1.000 22.727 0 773 HOH A O   1 ? 
HETATM 2844 O  O   . HOH N 5 .   ? 10.852  6.551   -20.864 1.000 20.629 0 774 HOH A O   1 ? 
HETATM 2845 O  O   . HOH N 5 .   ? 23.582  9.586   52.861  1.000 22.712 0 775 HOH A O   1 ? 
HETATM 2846 O  O   . HOH N 5 .   ? 23.036  27.724  15.228  1.000 16.156 0 776 HOH A O   1 ? 
HETATM 2847 O  O   . HOH N 5 .   ? 29.387  25.837  5.845   1.000 18.668 0 777 HOH A O   1 ? 
HETATM 2848 O  O   . HOH N 5 .   ? 8.907   22.212  14.090  1.000 20.450 0 778 HOH A O   1 ? 
HETATM 2849 O  O   . HOH N 5 .   ? 24.191  6.773   52.694  1.000 21.858 0 779 HOH A O   1 ? 
HETATM 2850 O  O   . HOH N 5 .   ? 24.974  10.857  38.319  1.000 32.847 0 780 HOH A O   1 ? 
HETATM 2851 O  O   . HOH N 5 .   ? 3.636   15.337  1.668   1.000 29.405 0 781 HOH A O   1 ? 
HETATM 2852 O  O   . HOH N 5 .   ? 8.529   9.822   14.189  1.000 23.510 0 782 HOH A O   1 ? 
HETATM 2853 O  O   . HOH N 5 .   ? 16.471  -7.341  24.751  1.000 25.631 0 783 HOH A O   1 ? 
HETATM 2854 O  O   . HOH N 5 .   ? -2.423  10.409  38.638  1.000 21.589 0 784 HOH A O   1 ? 
HETATM 2855 O  O   . HOH N 5 .   ? 6.381   21.426  14.296  1.000 26.376 0 785 HOH A O   1 ? 
# 
