data_9FZI
# 
_entry.id   9FZI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FZI         pdb_00009fzi 10.2210/pdb9fzi/pdb 
WWPDB D_1292139956 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-19 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FZI 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              delfosse@cbs.cnrs.fr 
_pdbx_contact_author.name_first         Vanessa 
_pdbx_contact_author.name_last          Delfosse 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7436-7935 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Carivenc, C.' 1 0000-0002-4413-9106 
'Blanc, P.'    2 0000-0001-5535-4242 
'Bourguet, W.' 3 0000-0002-0643-7719 
'Delfosse, V.' 4 0000-0002-7436-7935 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acta Crystallogr.,Sect.F' 
_citation.journal_id_ASTM           ACSFEN 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2053-230X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            81 
_citation.language                  ? 
_citation.page_first                85 
_citation.page_last                 94 
_citation.title                     
;A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1107/S2053230X2500069X 
_citation.pdbx_database_id_PubMed   39923198 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Carivenc, C.' 1 ? 
primary 'Laconde, G.'  2 ? 
primary 'Blanc, P.'    3 ? 
primary 'Amblard, M.'  4 ? 
primary 'Bourguet, W.' 5 ? 
primary 'Delfosse, V.' 6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1'                          
39479.477 2  2.3.1.48 ? ? ? 
2 non-polymer syn '[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER' 504.534 
2  ?        ? ? ? 
3 water       nat water                                                                                                   18.015 
43 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKKGHHHHHHGSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAK
WSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKG
AAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQ
HRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGSLVPR
GSSSHSSLTERHKILHRLLQEGSPS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKKGHHHHHHGSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAK
WSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKG
AAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQ
HRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGSLVPR
GSSSHSSLTERHKILHRLLQEGSPS
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER' SRL 
3 water                                                                                                   HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   LYS n 
1 4   GLY n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  GLY n 
1 12  SER n 
1 13  GLU n 
1 14  ARG n 
1 15  THR n 
1 16  GLY n 
1 17  THR n 
1 18  GLN n 
1 19  PRO n 
1 20  LEU n 
1 21  GLY n 
1 22  VAL n 
1 23  GLN n 
1 24  GLY n 
1 25  LEU n 
1 26  THR n 
1 27  GLU n 
1 28  GLU n 
1 29  GLN n 
1 30  ARG n 
1 31  MET n 
1 32  MET n 
1 33  ILE n 
1 34  ARG n 
1 35  GLU n 
1 36  LEU n 
1 37  MET n 
1 38  ASP n 
1 39  ALA n 
1 40  GLN n 
1 41  MET n 
1 42  LYS n 
1 43  THR n 
1 44  PHE n 
1 45  ASP n 
1 46  THR n 
1 47  THR n 
1 48  PHE n 
1 49  SER n 
1 50  HIS n 
1 51  PHE n 
1 52  LYS n 
1 53  ASN n 
1 54  PHE n 
1 55  ARG n 
1 56  LEU n 
1 57  PRO n 
1 58  GLY n 
1 59  VAL n 
1 60  LEU n 
1 61  SER n 
1 62  SER n 
1 63  GLY n 
1 64  CYS n 
1 65  GLU n 
1 66  LEU n 
1 67  PRO n 
1 68  GLU n 
1 69  SER n 
1 70  LEU n 
1 71  GLN n 
1 72  ALA n 
1 73  PRO n 
1 74  SER n 
1 75  ARG n 
1 76  GLU n 
1 77  GLU n 
1 78  ALA n 
1 79  ALA n 
1 80  LYS n 
1 81  TRP n 
1 82  SER n 
1 83  GLN n 
1 84  VAL n 
1 85  ARG n 
1 86  LYS n 
1 87  ASP n 
1 88  LEU n 
1 89  CYS n 
1 90  SER n 
1 91  LEU n 
1 92  LYS n 
1 93  VAL n 
1 94  SER n 
1 95  LEU n 
1 96  GLN n 
1 97  LEU n 
1 98  ARG n 
1 99  GLY n 
1 100 GLU n 
1 101 ASP n 
1 102 GLY n 
1 103 SER n 
1 104 VAL n 
1 105 TRP n 
1 106 ASN n 
1 107 TYR n 
1 108 LYS n 
1 109 PRO n 
1 110 PRO n 
1 111 ALA n 
1 112 ASP n 
1 113 SER n 
1 114 GLY n 
1 115 GLY n 
1 116 LYS n 
1 117 GLU n 
1 118 ILE n 
1 119 PHE n 
1 120 SER n 
1 121 LEU n 
1 122 LEU n 
1 123 PRO n 
1 124 HIS n 
1 125 MET n 
1 126 ALA n 
1 127 ASP n 
1 128 MET n 
1 129 SER n 
1 130 THR n 
1 131 TYR n 
1 132 MET n 
1 133 PHE n 
1 134 LYS n 
1 135 GLY n 
1 136 ILE n 
1 137 ILE n 
1 138 SER n 
1 139 PHE n 
1 140 ALA n 
1 141 LYS n 
1 142 VAL n 
1 143 ILE n 
1 144 SER n 
1 145 TYR n 
1 146 PHE n 
1 147 ARG n 
1 148 ASP n 
1 149 LEU n 
1 150 PRO n 
1 151 ILE n 
1 152 GLU n 
1 153 ASP n 
1 154 GLN n 
1 155 ILE n 
1 156 SER n 
1 157 LEU n 
1 158 LEU n 
1 159 LYS n 
1 160 GLY n 
1 161 ALA n 
1 162 ALA n 
1 163 PHE n 
1 164 GLU n 
1 165 LEU n 
1 166 CYS n 
1 167 GLN n 
1 168 LEU n 
1 169 ARG n 
1 170 PHE n 
1 171 ASN n 
1 172 THR n 
1 173 VAL n 
1 174 PHE n 
1 175 ASN n 
1 176 ALA n 
1 177 GLU n 
1 178 THR n 
1 179 GLY n 
1 180 THR n 
1 181 TRP n 
1 182 GLU n 
1 183 CYS n 
1 184 GLY n 
1 185 ARG n 
1 186 LEU n 
1 187 SER n 
1 188 TYR n 
1 189 CYS n 
1 190 LEU n 
1 191 GLU n 
1 192 ASP n 
1 193 THR n 
1 194 ALA n 
1 195 GLY n 
1 196 GLY n 
1 197 PHE n 
1 198 GLN n 
1 199 GLN n 
1 200 LEU n 
1 201 LEU n 
1 202 LEU n 
1 203 GLU n 
1 204 PRO n 
1 205 MET n 
1 206 LEU n 
1 207 LYS n 
1 208 PHE n 
1 209 HIS n 
1 210 TYR n 
1 211 MET n 
1 212 LEU n 
1 213 LYS n 
1 214 LYS n 
1 215 LEU n 
1 216 GLN n 
1 217 LEU n 
1 218 HIS n 
1 219 GLU n 
1 220 GLU n 
1 221 GLU n 
1 222 TYR n 
1 223 VAL n 
1 224 LEU n 
1 225 MET n 
1 226 GLN n 
1 227 ALA n 
1 228 ILE n 
1 229 SER n 
1 230 LEU n 
1 231 PHE n 
1 232 SER n 
1 233 PRO n 
1 234 ASP n 
1 235 ARG n 
1 236 PRO n 
1 237 GLY n 
1 238 VAL n 
1 239 LEU n 
1 240 GLN n 
1 241 HIS n 
1 242 ARG n 
1 243 VAL n 
1 244 VAL n 
1 245 ASP n 
1 246 GLN n 
1 247 LEU n 
1 248 GLN n 
1 249 GLU n 
1 250 GLN n 
1 251 PHE n 
1 252 ALA n 
1 253 ILE n 
1 254 THR n 
1 255 LEU n 
1 256 LYS n 
1 257 SER n 
1 258 TYR n 
1 259 ILE n 
1 260 GLU n 
1 261 CYS n 
1 262 ASN n 
1 263 ARG n 
1 264 PRO n 
1 265 GLN n 
1 266 PRO n 
1 267 ALA n 
1 268 HIS n 
1 269 ARG n 
1 270 PHE n 
1 271 LEU n 
1 272 PHE n 
1 273 LEU n 
1 274 LYS n 
1 275 ILE n 
1 276 MET n 
1 277 ALA n 
1 278 MET n 
1 279 LEU n 
1 280 THR n 
1 281 GLU n 
1 282 LEU n 
1 283 ARG n 
1 284 SER n 
1 285 ILE n 
1 286 ASN n 
1 287 ALA n 
1 288 GLN n 
1 289 HIS n 
1 290 THR n 
1 291 GLN n 
1 292 ARG n 
1 293 LEU n 
1 294 LEU n 
1 295 ARG n 
1 296 ILE n 
1 297 GLN n 
1 298 ASP n 
1 299 ILE n 
1 300 HIS n 
1 301 PRO n 
1 302 PHE n 
1 303 ALA n 
1 304 THR n 
1 305 PRO n 
1 306 LEU n 
1 307 MET n 
1 308 GLN n 
1 309 GLU n 
1 310 LEU n 
1 311 PHE n 
1 312 GLY n 
1 313 ILE n 
1 314 THR n 
1 315 GLY n 
1 316 SER n 
1 317 LEU n 
1 318 VAL n 
1 319 PRO n 
1 320 ARG n 
1 321 GLY n 
1 322 SER n 
1 323 SER n 
1 324 SER n 
1 325 HIS n 
1 326 SER n 
1 327 SER n 
1 328 LEU n 
1 329 THR n 
1 330 GLU n 
1 331 ARG n 
1 332 HIS n 
1 333 LYS n 
1 334 ILE n 
1 335 LEU n 
1 336 HIS n 
1 337 ARG n 
1 338 LEU n 
1 339 LEU n 
1 340 GLN n 
1 341 GLU n 
1 342 GLY n 
1 343 SER n 
1 344 PRO n 
1 345 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   316 human ? 'NR1I2, PXR'           ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 317 345 human ? 'NCOA1, BHLHE74, SRC1' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                 
?       'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                                
?       'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                              
?       'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                         
?       'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                                
?       'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                               
?       'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                         
?       'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                 
?       'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                               
?       'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                   
?       'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                              
?       'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                 
?       'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                  
?       'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                              
?       'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                           
?       'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                 
?       'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                  
?       'C3 H7 N O3'     105.093 
SRL non-polymer         . '[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER' 
SR12813 'C24 H42 O7 P2'  504.534 
THR 'L-peptide linking' y THREONINE                                                                                               
?       'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                              
?       'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                                
?       'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                                                                  
?       'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   119 ?   ?   ?   A . n 
A 1 2   LYS 2   120 ?   ?   ?   A . n 
A 1 3   LYS 3   121 ?   ?   ?   A . n 
A 1 4   GLY 4   122 ?   ?   ?   A . n 
A 1 5   HIS 5   123 ?   ?   ?   A . n 
A 1 6   HIS 6   124 ?   ?   ?   A . n 
A 1 7   HIS 7   125 ?   ?   ?   A . n 
A 1 8   HIS 8   126 ?   ?   ?   A . n 
A 1 9   HIS 9   127 ?   ?   ?   A . n 
A 1 10  HIS 10  128 ?   ?   ?   A . n 
A 1 11  GLY 11  129 ?   ?   ?   A . n 
A 1 12  SER 12  130 ?   ?   ?   A . n 
A 1 13  GLU 13  131 ?   ?   ?   A . n 
A 1 14  ARG 14  132 ?   ?   ?   A . n 
A 1 15  THR 15  133 ?   ?   ?   A . n 
A 1 16  GLY 16  134 ?   ?   ?   A . n 
A 1 17  THR 17  135 ?   ?   ?   A . n 
A 1 18  GLN 18  136 ?   ?   ?   A . n 
A 1 19  PRO 19  137 ?   ?   ?   A . n 
A 1 20  LEU 20  138 ?   ?   ?   A . n 
A 1 21  GLY 21  139 ?   ?   ?   A . n 
A 1 22  VAL 22  140 ?   ?   ?   A . n 
A 1 23  GLN 23  141 141 GLN GLN A . n 
A 1 24  GLY 24  142 142 GLY GLY A . n 
A 1 25  LEU 25  143 143 LEU LEU A . n 
A 1 26  THR 26  144 144 THR THR A . n 
A 1 27  GLU 27  145 145 GLU GLU A . n 
A 1 28  GLU 28  146 146 GLU GLU A . n 
A 1 29  GLN 29  147 147 GLN GLN A . n 
A 1 30  ARG 30  148 148 ARG ARG A . n 
A 1 31  MET 31  149 149 MET MET A . n 
A 1 32  MET 32  150 150 MET MET A . n 
A 1 33  ILE 33  151 151 ILE ILE A . n 
A 1 34  ARG 34  152 152 ARG ARG A . n 
A 1 35  GLU 35  153 153 GLU GLU A . n 
A 1 36  LEU 36  154 154 LEU LEU A . n 
A 1 37  MET 37  155 155 MET MET A . n 
A 1 38  ASP 38  156 156 ASP ASP A . n 
A 1 39  ALA 39  157 157 ALA ALA A . n 
A 1 40  GLN 40  158 158 GLN GLN A . n 
A 1 41  MET 41  159 159 MET MET A . n 
A 1 42  LYS 42  160 160 LYS LYS A . n 
A 1 43  THR 43  161 161 THR THR A . n 
A 1 44  PHE 44  162 162 PHE PHE A . n 
A 1 45  ASP 45  163 163 ASP ASP A . n 
A 1 46  THR 46  164 164 THR THR A . n 
A 1 47  THR 47  165 165 THR THR A . n 
A 1 48  PHE 48  166 166 PHE PHE A . n 
A 1 49  SER 49  167 167 SER SER A . n 
A 1 50  HIS 50  168 168 HIS HIS A . n 
A 1 51  PHE 51  169 169 PHE PHE A . n 
A 1 52  LYS 52  170 170 LYS LYS A . n 
A 1 53  ASN 53  171 171 ASN ASN A . n 
A 1 54  PHE 54  172 172 PHE PHE A . n 
A 1 55  ARG 55  173 173 ARG ARG A . n 
A 1 56  LEU 56  174 174 LEU LEU A . n 
A 1 57  PRO 57  175 175 PRO PRO A . n 
A 1 58  GLY 58  176 176 GLY GLY A . n 
A 1 59  VAL 59  177 ?   ?   ?   A . n 
A 1 60  LEU 60  178 ?   ?   ?   A . n 
A 1 61  SER 61  179 ?   ?   ?   A . n 
A 1 62  SER 62  180 ?   ?   ?   A . n 
A 1 63  GLY 63  181 ?   ?   ?   A . n 
A 1 64  CYS 64  182 ?   ?   ?   A . n 
A 1 65  GLU 65  183 ?   ?   ?   A . n 
A 1 66  LEU 66  184 ?   ?   ?   A . n 
A 1 67  PRO 67  185 ?   ?   ?   A . n 
A 1 68  GLU 68  186 ?   ?   ?   A . n 
A 1 69  SER 69  187 ?   ?   ?   A . n 
A 1 70  LEU 70  188 ?   ?   ?   A . n 
A 1 71  GLN 71  189 ?   ?   ?   A . n 
A 1 72  ALA 72  190 ?   ?   ?   A . n 
A 1 73  PRO 73  191 ?   ?   ?   A . n 
A 1 74  SER 74  192 192 SER SER A . n 
A 1 75  ARG 75  193 193 ARG ARG A . n 
A 1 76  GLU 76  194 194 GLU ALA A . n 
A 1 77  GLU 77  195 195 GLU GLU A . n 
A 1 78  ALA 78  196 196 ALA ALA A . n 
A 1 79  ALA 79  197 197 ALA ALA A . n 
A 1 80  LYS 80  198 198 LYS LYS A . n 
A 1 81  TRP 81  199 199 TRP TRP A . n 
A 1 82  SER 82  200 200 SER SER A . n 
A 1 83  GLN 83  201 201 GLN GLN A . n 
A 1 84  VAL 84  202 202 VAL VAL A . n 
A 1 85  ARG 85  203 203 ARG ARG A . n 
A 1 86  LYS 86  204 204 LYS LYS A . n 
A 1 87  ASP 87  205 205 ASP ASP A . n 
A 1 88  LEU 88  206 206 LEU LEU A . n 
A 1 89  CYS 89  207 207 CYS CYS A . n 
A 1 90  SER 90  208 208 SER SER A . n 
A 1 91  LEU 91  209 209 LEU LEU A . n 
A 1 92  LYS 92  210 210 LYS LYS A . n 
A 1 93  VAL 93  211 211 VAL VAL A . n 
A 1 94  SER 94  212 212 SER SER A . n 
A 1 95  LEU 95  213 213 LEU LEU A . n 
A 1 96  GLN 96  214 214 GLN GLN A . n 
A 1 97  LEU 97  215 215 LEU LEU A . n 
A 1 98  ARG 98  216 216 ARG ARG A . n 
A 1 99  GLY 99  217 217 GLY GLY A . n 
A 1 100 GLU 100 218 218 GLU GLU A . n 
A 1 101 ASP 101 219 219 ASP ASP A . n 
A 1 102 GLY 102 220 220 GLY GLY A . n 
A 1 103 SER 103 221 221 SER SER A . n 
A 1 104 VAL 104 222 222 VAL VAL A . n 
A 1 105 TRP 105 223 223 TRP TRP A . n 
A 1 106 ASN 106 224 224 ASN ASN A . n 
A 1 107 TYR 107 225 225 TYR TYR A . n 
A 1 108 LYS 108 226 226 LYS LYS A . n 
A 1 109 PRO 109 227 227 PRO PRO A . n 
A 1 110 PRO 110 228 228 PRO PRO A . n 
A 1 111 ALA 111 229 229 ALA ALA A . n 
A 1 112 ASP 112 230 230 ASP ASP A . n 
A 1 113 SER 113 231 231 SER SER A . n 
A 1 114 GLY 114 232 232 GLY GLY A . n 
A 1 115 GLY 115 233 233 GLY GLY A . n 
A 1 116 LYS 116 234 234 LYS LYS A . n 
A 1 117 GLU 117 235 235 GLU GLU A . n 
A 1 118 ILE 118 236 236 ILE ILE A . n 
A 1 119 PHE 119 237 237 PHE PHE A . n 
A 1 120 SER 120 238 238 SER SER A . n 
A 1 121 LEU 121 239 239 LEU LEU A . n 
A 1 122 LEU 122 240 240 LEU LEU A . n 
A 1 123 PRO 123 241 241 PRO PRO A . n 
A 1 124 HIS 124 242 242 HIS HIS A . n 
A 1 125 MET 125 243 243 MET MET A . n 
A 1 126 ALA 126 244 244 ALA ALA A . n 
A 1 127 ASP 127 245 245 ASP ASP A . n 
A 1 128 MET 128 246 246 MET MET A . n 
A 1 129 SER 129 247 247 SER SER A . n 
A 1 130 THR 130 248 248 THR THR A . n 
A 1 131 TYR 131 249 249 TYR TYR A . n 
A 1 132 MET 132 250 250 MET MET A . n 
A 1 133 PHE 133 251 251 PHE PHE A . n 
A 1 134 LYS 134 252 252 LYS LYS A . n 
A 1 135 GLY 135 253 253 GLY GLY A . n 
A 1 136 ILE 136 254 254 ILE ILE A . n 
A 1 137 ILE 137 255 255 ILE ILE A . n 
A 1 138 SER 138 256 256 SER SER A . n 
A 1 139 PHE 139 257 257 PHE PHE A . n 
A 1 140 ALA 140 258 258 ALA ALA A . n 
A 1 141 LYS 141 259 259 LYS LYS A . n 
A 1 142 VAL 142 260 260 VAL VAL A . n 
A 1 143 ILE 143 261 261 ILE ILE A . n 
A 1 144 SER 144 262 262 SER SER A . n 
A 1 145 TYR 145 263 263 TYR TYR A . n 
A 1 146 PHE 146 264 264 PHE PHE A . n 
A 1 147 ARG 147 265 265 ARG ARG A . n 
A 1 148 ASP 148 266 266 ASP ASP A . n 
A 1 149 LEU 149 267 267 LEU LEU A . n 
A 1 150 PRO 150 268 268 PRO PRO A . n 
A 1 151 ILE 151 269 269 ILE ILE A . n 
A 1 152 GLU 152 270 270 GLU GLU A . n 
A 1 153 ASP 153 271 271 ASP ASP A . n 
A 1 154 GLN 154 272 272 GLN GLN A . n 
A 1 155 ILE 155 273 273 ILE ILE A . n 
A 1 156 SER 156 274 274 SER SER A . n 
A 1 157 LEU 157 275 275 LEU LEU A . n 
A 1 158 LEU 158 276 276 LEU LEU A . n 
A 1 159 LYS 159 277 277 LYS LYS A . n 
A 1 160 GLY 160 278 278 GLY GLY A . n 
A 1 161 ALA 161 279 279 ALA ALA A . n 
A 1 162 ALA 162 280 280 ALA ALA A . n 
A 1 163 PHE 163 281 281 PHE PHE A . n 
A 1 164 GLU 164 282 282 GLU GLU A . n 
A 1 165 LEU 165 283 283 LEU LEU A . n 
A 1 166 CYS 166 284 284 CYS CYS A . n 
A 1 167 GLN 167 285 285 GLN GLN A . n 
A 1 168 LEU 168 286 286 LEU LEU A . n 
A 1 169 ARG 169 287 287 ARG ARG A . n 
A 1 170 PHE 170 288 288 PHE PHE A . n 
A 1 171 ASN 171 289 289 ASN ASN A . n 
A 1 172 THR 172 290 290 THR THR A . n 
A 1 173 VAL 173 291 291 VAL VAL A . n 
A 1 174 PHE 174 292 292 PHE PHE A . n 
A 1 175 ASN 175 293 293 ASN ASN A . n 
A 1 176 ALA 176 294 294 ALA ALA A . n 
A 1 177 GLU 177 295 295 GLU GLU A . n 
A 1 178 THR 178 296 296 THR THR A . n 
A 1 179 GLY 179 297 297 GLY GLY A . n 
A 1 180 THR 180 298 298 THR THR A . n 
A 1 181 TRP 181 299 299 TRP TRP A . n 
A 1 182 GLU 182 300 300 GLU GLU A . n 
A 1 183 CYS 183 301 301 CYS CYS A . n 
A 1 184 GLY 184 302 302 GLY GLY A . n 
A 1 185 ARG 185 303 303 ARG ARG A . n 
A 1 186 LEU 186 304 304 LEU LEU A . n 
A 1 187 SER 187 305 305 SER SER A . n 
A 1 188 TYR 188 306 306 TYR TYR A . n 
A 1 189 CYS 189 307 307 CYS CYS A . n 
A 1 190 LEU 190 308 308 LEU LEU A . n 
A 1 191 GLU 191 309 309 GLU GLU A . n 
A 1 192 ASP 192 310 310 ASP ASP A . n 
A 1 193 THR 193 311 311 THR THR A . n 
A 1 194 ALA 194 312 ?   ?   ?   A . n 
A 1 195 GLY 195 313 ?   ?   ?   A . n 
A 1 196 GLY 196 314 ?   ?   ?   A . n 
A 1 197 PHE 197 315 315 PHE PHE A . n 
A 1 198 GLN 198 316 316 GLN GLN A . n 
A 1 199 GLN 199 317 317 GLN GLN A . n 
A 1 200 LEU 200 318 318 LEU LEU A . n 
A 1 201 LEU 201 319 319 LEU LEU A . n 
A 1 202 LEU 202 320 320 LEU LEU A . n 
A 1 203 GLU 203 321 321 GLU GLU A . n 
A 1 204 PRO 204 322 322 PRO PRO A . n 
A 1 205 MET 205 323 323 MET MET A . n 
A 1 206 LEU 206 324 324 LEU LEU A . n 
A 1 207 LYS 207 325 325 LYS LYS A . n 
A 1 208 PHE 208 326 326 PHE PHE A . n 
A 1 209 HIS 209 327 327 HIS HIS A . n 
A 1 210 TYR 210 328 328 TYR TYR A . n 
A 1 211 MET 211 329 329 MET MET A . n 
A 1 212 LEU 212 330 330 LEU LEU A . n 
A 1 213 LYS 213 331 331 LYS LYS A . n 
A 1 214 LYS 214 332 332 LYS LYS A . n 
A 1 215 LEU 215 333 333 LEU LEU A . n 
A 1 216 GLN 216 334 334 GLN GLN A . n 
A 1 217 LEU 217 335 335 LEU LEU A . n 
A 1 218 HIS 218 336 336 HIS HIS A . n 
A 1 219 GLU 219 337 337 GLU GLU A . n 
A 1 220 GLU 220 338 338 GLU GLU A . n 
A 1 221 GLU 221 339 339 GLU GLU A . n 
A 1 222 TYR 222 340 340 TYR TYR A . n 
A 1 223 VAL 223 341 341 VAL VAL A . n 
A 1 224 LEU 224 342 342 LEU LEU A . n 
A 1 225 MET 225 343 343 MET MET A . n 
A 1 226 GLN 226 344 344 GLN GLN A . n 
A 1 227 ALA 227 345 345 ALA ALA A . n 
A 1 228 ILE 228 346 346 ILE ILE A . n 
A 1 229 SER 229 347 347 SER SER A . n 
A 1 230 LEU 230 348 348 LEU LEU A . n 
A 1 231 PHE 231 349 349 PHE PHE A . n 
A 1 232 SER 232 350 350 SER SER A . n 
A 1 233 PRO 233 351 351 PRO PRO A . n 
A 1 234 ASP 234 352 352 ASP ASP A . n 
A 1 235 ARG 235 353 353 ARG ARG A . n 
A 1 236 PRO 236 354 354 PRO PRO A . n 
A 1 237 GLY 237 355 355 GLY GLY A . n 
A 1 238 VAL 238 356 356 VAL VAL A . n 
A 1 239 LEU 239 357 357 LEU LEU A . n 
A 1 240 GLN 240 358 358 GLN GLN A . n 
A 1 241 HIS 241 359 359 HIS HIS A . n 
A 1 242 ARG 242 360 360 ARG ARG A . n 
A 1 243 VAL 243 361 361 VAL VAL A . n 
A 1 244 VAL 244 362 362 VAL VAL A . n 
A 1 245 ASP 245 363 363 ASP ASP A . n 
A 1 246 GLN 246 364 364 GLN GLN A . n 
A 1 247 LEU 247 365 365 LEU LEU A . n 
A 1 248 GLN 248 366 366 GLN GLN A . n 
A 1 249 GLU 249 367 367 GLU GLU A . n 
A 1 250 GLN 250 368 368 GLN GLN A . n 
A 1 251 PHE 251 369 369 PHE PHE A . n 
A 1 252 ALA 252 370 370 ALA ALA A . n 
A 1 253 ILE 253 371 371 ILE ILE A . n 
A 1 254 THR 254 372 372 THR THR A . n 
A 1 255 LEU 255 373 373 LEU LEU A . n 
A 1 256 LYS 256 374 374 LYS LYS A . n 
A 1 257 SER 257 375 375 SER SER A . n 
A 1 258 TYR 258 376 376 TYR TYR A . n 
A 1 259 ILE 259 377 377 ILE ILE A . n 
A 1 260 GLU 260 378 378 GLU GLU A . n 
A 1 261 CYS 261 379 379 CYS CYS A . n 
A 1 262 ASN 262 380 380 ASN ASN A . n 
A 1 263 ARG 263 381 381 ARG ARG A . n 
A 1 264 PRO 264 382 382 PRO PRO A . n 
A 1 265 GLN 265 383 383 GLN GLN A . n 
A 1 266 PRO 266 384 384 PRO PRO A . n 
A 1 267 ALA 267 385 385 ALA ALA A . n 
A 1 268 HIS 268 386 386 HIS HIS A . n 
A 1 269 ARG 269 387 387 ARG ARG A . n 
A 1 270 PHE 270 388 388 PHE PHE A . n 
A 1 271 LEU 271 389 389 LEU LEU A . n 
A 1 272 PHE 272 390 390 PHE PHE A . n 
A 1 273 LEU 273 391 391 LEU LEU A . n 
A 1 274 LYS 274 392 392 LYS LYS A . n 
A 1 275 ILE 275 393 393 ILE ILE A . n 
A 1 276 MET 276 394 394 MET MET A . n 
A 1 277 ALA 277 395 395 ALA ALA A . n 
A 1 278 MET 278 396 396 MET MET A . n 
A 1 279 LEU 279 397 397 LEU LEU A . n 
A 1 280 THR 280 398 398 THR THR A . n 
A 1 281 GLU 281 399 399 GLU GLU A . n 
A 1 282 LEU 282 400 400 LEU LEU A . n 
A 1 283 ARG 283 401 401 ARG ARG A . n 
A 1 284 SER 284 402 402 SER SER A . n 
A 1 285 ILE 285 403 403 ILE ILE A . n 
A 1 286 ASN 286 404 404 ASN ASN A . n 
A 1 287 ALA 287 405 405 ALA ALA A . n 
A 1 288 GLN 288 406 406 GLN GLN A . n 
A 1 289 HIS 289 407 407 HIS HIS A . n 
A 1 290 THR 290 408 408 THR THR A . n 
A 1 291 GLN 291 409 409 GLN GLN A . n 
A 1 292 ARG 292 410 410 ARG ARG A . n 
A 1 293 LEU 293 411 411 LEU LEU A . n 
A 1 294 LEU 294 412 412 LEU LEU A . n 
A 1 295 ARG 295 413 413 ARG ARG A . n 
A 1 296 ILE 296 414 414 ILE ILE A . n 
A 1 297 GLN 297 415 415 GLN GLN A . n 
A 1 298 ASP 298 416 416 ASP ASP A . n 
A 1 299 ILE 299 417 417 ILE ILE A . n 
A 1 300 HIS 300 418 418 HIS HIS A . n 
A 1 301 PRO 301 419 419 PRO PRO A . n 
A 1 302 PHE 302 420 420 PHE PHE A . n 
A 1 303 ALA 303 421 421 ALA ALA A . n 
A 1 304 THR 304 422 422 THR THR A . n 
A 1 305 PRO 305 423 423 PRO PRO A . n 
A 1 306 LEU 306 424 424 LEU LEU A . n 
A 1 307 MET 307 425 425 MET MET A . n 
A 1 308 GLN 308 426 426 GLN GLN A . n 
A 1 309 GLU 309 427 427 GLU GLU A . n 
A 1 310 LEU 310 428 428 LEU LEU A . n 
A 1 311 PHE 311 429 429 PHE PHE A . n 
A 1 312 GLY 312 430 430 GLY GLY A . n 
A 1 313 ILE 313 431 431 ILE ILE A . n 
A 1 314 THR 314 432 432 THR THR A . n 
A 1 315 GLY 315 433 ?   ?   ?   A . n 
A 1 316 SER 316 434 ?   ?   ?   A . n 
A 1 317 LEU 317 435 ?   ?   ?   A . n 
A 1 318 VAL 318 436 ?   ?   ?   A . n 
A 1 319 PRO 319 437 ?   ?   ?   A . n 
A 1 320 ARG 320 438 ?   ?   ?   A . n 
A 1 321 GLY 321 439 ?   ?   ?   A . n 
A 1 322 SER 322 440 ?   ?   ?   A . n 
A 1 323 SER 323 441 ?   ?   ?   A . n 
A 1 324 SER 324 442 ?   ?   ?   A . n 
A 1 325 HIS 325 443 ?   ?   ?   A . n 
A 1 326 SER 326 444 ?   ?   ?   A . n 
A 1 327 SER 327 445 445 SER SER A . n 
A 1 328 LEU 328 446 446 LEU LEU A . n 
A 1 329 THR 329 447 447 THR THR A . n 
A 1 330 GLU 330 448 448 GLU GLU A . n 
A 1 331 ARG 331 449 449 ARG ARG A . n 
A 1 332 HIS 332 450 450 HIS HIS A . n 
A 1 333 LYS 333 451 451 LYS LYS A . n 
A 1 334 ILE 334 452 452 ILE ILE A . n 
A 1 335 LEU 335 453 453 LEU LEU A . n 
A 1 336 HIS 336 454 454 HIS HIS A . n 
A 1 337 ARG 337 455 455 ARG ARG A . n 
A 1 338 LEU 338 456 456 LEU LEU A . n 
A 1 339 LEU 339 457 457 LEU LEU A . n 
A 1 340 GLN 340 458 458 GLN GLN A . n 
A 1 341 GLU 341 459 459 GLU GLU A . n 
A 1 342 GLY 342 460 460 GLY GLY A . n 
A 1 343 SER 343 461 ?   ?   ?   A . n 
A 1 344 PRO 344 462 ?   ?   ?   A . n 
A 1 345 SER 345 463 ?   ?   ?   A . n 
B 1 1   MET 1   119 ?   ?   ?   B . n 
B 1 2   LYS 2   120 ?   ?   ?   B . n 
B 1 3   LYS 3   121 ?   ?   ?   B . n 
B 1 4   GLY 4   122 ?   ?   ?   B . n 
B 1 5   HIS 5   123 ?   ?   ?   B . n 
B 1 6   HIS 6   124 ?   ?   ?   B . n 
B 1 7   HIS 7   125 ?   ?   ?   B . n 
B 1 8   HIS 8   126 ?   ?   ?   B . n 
B 1 9   HIS 9   127 ?   ?   ?   B . n 
B 1 10  HIS 10  128 ?   ?   ?   B . n 
B 1 11  GLY 11  129 ?   ?   ?   B . n 
B 1 12  SER 12  130 ?   ?   ?   B . n 
B 1 13  GLU 13  131 ?   ?   ?   B . n 
B 1 14  ARG 14  132 ?   ?   ?   B . n 
B 1 15  THR 15  133 ?   ?   ?   B . n 
B 1 16  GLY 16  134 ?   ?   ?   B . n 
B 1 17  THR 17  135 ?   ?   ?   B . n 
B 1 18  GLN 18  136 ?   ?   ?   B . n 
B 1 19  PRO 19  137 ?   ?   ?   B . n 
B 1 20  LEU 20  138 ?   ?   ?   B . n 
B 1 21  GLY 21  139 ?   ?   ?   B . n 
B 1 22  VAL 22  140 ?   ?   ?   B . n 
B 1 23  GLN 23  141 ?   ?   ?   B . n 
B 1 24  GLY 24  142 ?   ?   ?   B . n 
B 1 25  LEU 25  143 143 LEU LEU B . n 
B 1 26  THR 26  144 144 THR THR B . n 
B 1 27  GLU 27  145 145 GLU GLU B . n 
B 1 28  GLU 28  146 146 GLU GLU B . n 
B 1 29  GLN 29  147 147 GLN GLN B . n 
B 1 30  ARG 30  148 148 ARG ARG B . n 
B 1 31  MET 31  149 149 MET MET B . n 
B 1 32  MET 32  150 150 MET MET B . n 
B 1 33  ILE 33  151 151 ILE ILE B . n 
B 1 34  ARG 34  152 152 ARG ARG B . n 
B 1 35  GLU 35  153 153 GLU GLU B . n 
B 1 36  LEU 36  154 154 LEU LEU B . n 
B 1 37  MET 37  155 155 MET MET B . n 
B 1 38  ASP 38  156 156 ASP ASP B . n 
B 1 39  ALA 39  157 157 ALA ALA B . n 
B 1 40  GLN 40  158 158 GLN GLN B . n 
B 1 41  MET 41  159 159 MET MET B . n 
B 1 42  LYS 42  160 160 LYS LYS B . n 
B 1 43  THR 43  161 161 THR THR B . n 
B 1 44  PHE 44  162 162 PHE PHE B . n 
B 1 45  ASP 45  163 163 ASP ASP B . n 
B 1 46  THR 46  164 164 THR THR B . n 
B 1 47  THR 47  165 165 THR THR B . n 
B 1 48  PHE 48  166 166 PHE PHE B . n 
B 1 49  SER 49  167 167 SER SER B . n 
B 1 50  HIS 50  168 168 HIS HIS B . n 
B 1 51  PHE 51  169 169 PHE PHE B . n 
B 1 52  LYS 52  170 170 LYS LYS B . n 
B 1 53  ASN 53  171 171 ASN ASN B . n 
B 1 54  PHE 54  172 172 PHE PHE B . n 
B 1 55  ARG 55  173 173 ARG ARG B . n 
B 1 56  LEU 56  174 174 LEU LEU B . n 
B 1 57  PRO 57  175 175 PRO PRO B . n 
B 1 58  GLY 58  176 176 GLY GLY B . n 
B 1 59  VAL 59  177 ?   ?   ?   B . n 
B 1 60  LEU 60  178 ?   ?   ?   B . n 
B 1 61  SER 61  179 ?   ?   ?   B . n 
B 1 62  SER 62  180 ?   ?   ?   B . n 
B 1 63  GLY 63  181 ?   ?   ?   B . n 
B 1 64  CYS 64  182 ?   ?   ?   B . n 
B 1 65  GLU 65  183 ?   ?   ?   B . n 
B 1 66  LEU 66  184 ?   ?   ?   B . n 
B 1 67  PRO 67  185 ?   ?   ?   B . n 
B 1 68  GLU 68  186 ?   ?   ?   B . n 
B 1 69  SER 69  187 ?   ?   ?   B . n 
B 1 70  LEU 70  188 ?   ?   ?   B . n 
B 1 71  GLN 71  189 ?   ?   ?   B . n 
B 1 72  ALA 72  190 ?   ?   ?   B . n 
B 1 73  PRO 73  191 ?   ?   ?   B . n 
B 1 74  SER 74  192 ?   ?   ?   B . n 
B 1 75  ARG 75  193 ?   ?   ?   B . n 
B 1 76  GLU 76  194 ?   ?   ?   B . n 
B 1 77  GLU 77  195 195 GLU GLU B . n 
B 1 78  ALA 78  196 196 ALA ALA B . n 
B 1 79  ALA 79  197 197 ALA ALA B . n 
B 1 80  LYS 80  198 198 LYS LYS B . n 
B 1 81  TRP 81  199 199 TRP TRP B . n 
B 1 82  SER 82  200 200 SER SER B . n 
B 1 83  GLN 83  201 201 GLN GLN B . n 
B 1 84  VAL 84  202 202 VAL VAL B . n 
B 1 85  ARG 85  203 203 ARG ARG B . n 
B 1 86  LYS 86  204 204 LYS LYS B . n 
B 1 87  ASP 87  205 205 ASP ASP B . n 
B 1 88  LEU 88  206 206 LEU LEU B . n 
B 1 89  CYS 89  207 207 CYS CYS B . n 
B 1 90  SER 90  208 208 SER SER B . n 
B 1 91  LEU 91  209 209 LEU LEU B . n 
B 1 92  LYS 92  210 210 LYS LYS B . n 
B 1 93  VAL 93  211 211 VAL VAL B . n 
B 1 94  SER 94  212 212 SER SER B . n 
B 1 95  LEU 95  213 213 LEU LEU B . n 
B 1 96  GLN 96  214 214 GLN GLN B . n 
B 1 97  LEU 97  215 215 LEU LEU B . n 
B 1 98  ARG 98  216 216 ARG ARG B . n 
B 1 99  GLY 99  217 217 GLY GLY B . n 
B 1 100 GLU 100 218 218 GLU GLU B . n 
B 1 101 ASP 101 219 219 ASP ASP B . n 
B 1 102 GLY 102 220 220 GLY GLY B . n 
B 1 103 SER 103 221 221 SER SER B . n 
B 1 104 VAL 104 222 222 VAL VAL B . n 
B 1 105 TRP 105 223 223 TRP TRP B . n 
B 1 106 ASN 106 224 224 ASN ASN B . n 
B 1 107 TYR 107 225 225 TYR TYR B . n 
B 1 108 LYS 108 226 226 LYS LYS B . n 
B 1 109 PRO 109 227 227 PRO PRO B . n 
B 1 110 PRO 110 228 228 PRO PRO B . n 
B 1 111 ALA 111 229 229 ALA ALA B . n 
B 1 112 ASP 112 230 230 ASP ASP B . n 
B 1 113 SER 113 231 231 SER SER B . n 
B 1 114 GLY 114 232 232 GLY GLY B . n 
B 1 115 GLY 115 233 233 GLY GLY B . n 
B 1 116 LYS 116 234 234 LYS LYS B . n 
B 1 117 GLU 117 235 235 GLU GLU B . n 
B 1 118 ILE 118 236 236 ILE ILE B . n 
B 1 119 PHE 119 237 237 PHE PHE B . n 
B 1 120 SER 120 238 238 SER SER B . n 
B 1 121 LEU 121 239 239 LEU LEU B . n 
B 1 122 LEU 122 240 240 LEU LEU B . n 
B 1 123 PRO 123 241 241 PRO PRO B . n 
B 1 124 HIS 124 242 242 HIS HIS B . n 
B 1 125 MET 125 243 243 MET MET B . n 
B 1 126 ALA 126 244 244 ALA ALA B . n 
B 1 127 ASP 127 245 245 ASP ASP B . n 
B 1 128 MET 128 246 246 MET MET B . n 
B 1 129 SER 129 247 247 SER SER B . n 
B 1 130 THR 130 248 248 THR THR B . n 
B 1 131 TYR 131 249 249 TYR TYR B . n 
B 1 132 MET 132 250 250 MET MET B . n 
B 1 133 PHE 133 251 251 PHE PHE B . n 
B 1 134 LYS 134 252 252 LYS LYS B . n 
B 1 135 GLY 135 253 253 GLY GLY B . n 
B 1 136 ILE 136 254 254 ILE ILE B . n 
B 1 137 ILE 137 255 255 ILE ILE B . n 
B 1 138 SER 138 256 256 SER SER B . n 
B 1 139 PHE 139 257 257 PHE PHE B . n 
B 1 140 ALA 140 258 258 ALA ALA B . n 
B 1 141 LYS 141 259 259 LYS LYS B . n 
B 1 142 VAL 142 260 260 VAL VAL B . n 
B 1 143 ILE 143 261 261 ILE ILE B . n 
B 1 144 SER 144 262 262 SER SER B . n 
B 1 145 TYR 145 263 263 TYR TYR B . n 
B 1 146 PHE 146 264 264 PHE PHE B . n 
B 1 147 ARG 147 265 265 ARG ARG B . n 
B 1 148 ASP 148 266 266 ASP ASP B . n 
B 1 149 LEU 149 267 267 LEU LEU B . n 
B 1 150 PRO 150 268 268 PRO PRO B . n 
B 1 151 ILE 151 269 269 ILE ILE B . n 
B 1 152 GLU 152 270 270 GLU GLU B . n 
B 1 153 ASP 153 271 271 ASP ASP B . n 
B 1 154 GLN 154 272 272 GLN GLN B . n 
B 1 155 ILE 155 273 273 ILE ILE B . n 
B 1 156 SER 156 274 274 SER SER B . n 
B 1 157 LEU 157 275 275 LEU LEU B . n 
B 1 158 LEU 158 276 276 LEU LEU B . n 
B 1 159 LYS 159 277 277 LYS LYS B . n 
B 1 160 GLY 160 278 278 GLY GLY B . n 
B 1 161 ALA 161 279 279 ALA ALA B . n 
B 1 162 ALA 162 280 280 ALA ALA B . n 
B 1 163 PHE 163 281 281 PHE PHE B . n 
B 1 164 GLU 164 282 282 GLU GLU B . n 
B 1 165 LEU 165 283 283 LEU LEU B . n 
B 1 166 CYS 166 284 284 CYS CYS B . n 
B 1 167 GLN 167 285 285 GLN GLN B . n 
B 1 168 LEU 168 286 286 LEU LEU B . n 
B 1 169 ARG 169 287 287 ARG ARG B . n 
B 1 170 PHE 170 288 288 PHE PHE B . n 
B 1 171 ASN 171 289 289 ASN ASN B . n 
B 1 172 THR 172 290 290 THR THR B . n 
B 1 173 VAL 173 291 291 VAL VAL B . n 
B 1 174 PHE 174 292 292 PHE PHE B . n 
B 1 175 ASN 175 293 293 ASN ASN B . n 
B 1 176 ALA 176 294 294 ALA ALA B . n 
B 1 177 GLU 177 295 295 GLU GLU B . n 
B 1 178 THR 178 296 296 THR THR B . n 
B 1 179 GLY 179 297 297 GLY GLY B . n 
B 1 180 THR 180 298 298 THR THR B . n 
B 1 181 TRP 181 299 299 TRP TRP B . n 
B 1 182 GLU 182 300 300 GLU GLU B . n 
B 1 183 CYS 183 301 301 CYS CYS B . n 
B 1 184 GLY 184 302 302 GLY GLY B . n 
B 1 185 ARG 185 303 303 ARG ARG B . n 
B 1 186 LEU 186 304 304 LEU LEU B . n 
B 1 187 SER 187 305 305 SER SER B . n 
B 1 188 TYR 188 306 306 TYR TYR B . n 
B 1 189 CYS 189 307 307 CYS CYS B . n 
B 1 190 LEU 190 308 308 LEU LEU B . n 
B 1 191 GLU 191 309 309 GLU GLU B . n 
B 1 192 ASP 192 310 310 ASP ASP B . n 
B 1 193 THR 193 311 ?   ?   ?   B . n 
B 1 194 ALA 194 312 ?   ?   ?   B . n 
B 1 195 GLY 195 313 ?   ?   ?   B . n 
B 1 196 GLY 196 314 314 GLY GLY B . n 
B 1 197 PHE 197 315 315 PHE PHE B . n 
B 1 198 GLN 198 316 316 GLN GLN B . n 
B 1 199 GLN 199 317 317 GLN GLN B . n 
B 1 200 LEU 200 318 318 LEU LEU B . n 
B 1 201 LEU 201 319 319 LEU LEU B . n 
B 1 202 LEU 202 320 320 LEU LEU B . n 
B 1 203 GLU 203 321 321 GLU GLU B . n 
B 1 204 PRO 204 322 322 PRO PRO B . n 
B 1 205 MET 205 323 323 MET MET B . n 
B 1 206 LEU 206 324 324 LEU LEU B . n 
B 1 207 LYS 207 325 325 LYS LYS B . n 
B 1 208 PHE 208 326 326 PHE PHE B . n 
B 1 209 HIS 209 327 327 HIS HIS B . n 
B 1 210 TYR 210 328 328 TYR TYR B . n 
B 1 211 MET 211 329 329 MET MET B . n 
B 1 212 LEU 212 330 330 LEU LEU B . n 
B 1 213 LYS 213 331 331 LYS LYS B . n 
B 1 214 LYS 214 332 332 LYS LYS B . n 
B 1 215 LEU 215 333 333 LEU LEU B . n 
B 1 216 GLN 216 334 334 GLN GLN B . n 
B 1 217 LEU 217 335 335 LEU LEU B . n 
B 1 218 HIS 218 336 336 HIS HIS B . n 
B 1 219 GLU 219 337 337 GLU GLU B . n 
B 1 220 GLU 220 338 338 GLU GLU B . n 
B 1 221 GLU 221 339 339 GLU GLU B . n 
B 1 222 TYR 222 340 340 TYR TYR B . n 
B 1 223 VAL 223 341 341 VAL VAL B . n 
B 1 224 LEU 224 342 342 LEU LEU B . n 
B 1 225 MET 225 343 343 MET MET B . n 
B 1 226 GLN 226 344 344 GLN GLN B . n 
B 1 227 ALA 227 345 345 ALA ALA B . n 
B 1 228 ILE 228 346 346 ILE ILE B . n 
B 1 229 SER 229 347 347 SER SER B . n 
B 1 230 LEU 230 348 348 LEU LEU B . n 
B 1 231 PHE 231 349 349 PHE PHE B . n 
B 1 232 SER 232 350 350 SER SER B . n 
B 1 233 PRO 233 351 351 PRO PRO B . n 
B 1 234 ASP 234 352 352 ASP ASP B . n 
B 1 235 ARG 235 353 353 ARG ARG B . n 
B 1 236 PRO 236 354 354 PRO PRO B . n 
B 1 237 GLY 237 355 355 GLY GLY B . n 
B 1 238 VAL 238 356 356 VAL VAL B . n 
B 1 239 LEU 239 357 357 LEU LEU B . n 
B 1 240 GLN 240 358 358 GLN GLN B . n 
B 1 241 HIS 241 359 359 HIS HIS B . n 
B 1 242 ARG 242 360 360 ARG ARG B . n 
B 1 243 VAL 243 361 361 VAL VAL B . n 
B 1 244 VAL 244 362 362 VAL VAL B . n 
B 1 245 ASP 245 363 363 ASP ASP B . n 
B 1 246 GLN 246 364 364 GLN GLN B . n 
B 1 247 LEU 247 365 365 LEU LEU B . n 
B 1 248 GLN 248 366 366 GLN GLN B . n 
B 1 249 GLU 249 367 367 GLU GLU B . n 
B 1 250 GLN 250 368 368 GLN GLN B . n 
B 1 251 PHE 251 369 369 PHE PHE B . n 
B 1 252 ALA 252 370 370 ALA ALA B . n 
B 1 253 ILE 253 371 371 ILE ILE B . n 
B 1 254 THR 254 372 372 THR THR B . n 
B 1 255 LEU 255 373 373 LEU LEU B . n 
B 1 256 LYS 256 374 374 LYS LYS B . n 
B 1 257 SER 257 375 375 SER SER B . n 
B 1 258 TYR 258 376 376 TYR TYR B . n 
B 1 259 ILE 259 377 377 ILE ILE B . n 
B 1 260 GLU 260 378 378 GLU GLU B . n 
B 1 261 CYS 261 379 379 CYS CYS B . n 
B 1 262 ASN 262 380 380 ASN ASN B . n 
B 1 263 ARG 263 381 381 ARG ARG B . n 
B 1 264 PRO 264 382 382 PRO PRO B . n 
B 1 265 GLN 265 383 383 GLN GLN B . n 
B 1 266 PRO 266 384 384 PRO PRO B . n 
B 1 267 ALA 267 385 385 ALA ALA B . n 
B 1 268 HIS 268 386 386 HIS HIS B . n 
B 1 269 ARG 269 387 387 ARG ARG B . n 
B 1 270 PHE 270 388 388 PHE PHE B . n 
B 1 271 LEU 271 389 389 LEU LEU B . n 
B 1 272 PHE 272 390 390 PHE PHE B . n 
B 1 273 LEU 273 391 391 LEU LEU B . n 
B 1 274 LYS 274 392 392 LYS LYS B . n 
B 1 275 ILE 275 393 393 ILE ILE B . n 
B 1 276 MET 276 394 394 MET MET B . n 
B 1 277 ALA 277 395 395 ALA ALA B . n 
B 1 278 MET 278 396 396 MET MET B . n 
B 1 279 LEU 279 397 397 LEU LEU B . n 
B 1 280 THR 280 398 398 THR THR B . n 
B 1 281 GLU 281 399 399 GLU GLU B . n 
B 1 282 LEU 282 400 400 LEU LEU B . n 
B 1 283 ARG 283 401 401 ARG ARG B . n 
B 1 284 SER 284 402 402 SER SER B . n 
B 1 285 ILE 285 403 403 ILE ILE B . n 
B 1 286 ASN 286 404 404 ASN ASN B . n 
B 1 287 ALA 287 405 405 ALA ALA B . n 
B 1 288 GLN 288 406 406 GLN GLN B . n 
B 1 289 HIS 289 407 407 HIS HIS B . n 
B 1 290 THR 290 408 408 THR THR B . n 
B 1 291 GLN 291 409 409 GLN GLN B . n 
B 1 292 ARG 292 410 410 ARG ARG B . n 
B 1 293 LEU 293 411 411 LEU LEU B . n 
B 1 294 LEU 294 412 412 LEU LEU B . n 
B 1 295 ARG 295 413 413 ARG ARG B . n 
B 1 296 ILE 296 414 414 ILE ILE B . n 
B 1 297 GLN 297 415 415 GLN GLN B . n 
B 1 298 ASP 298 416 416 ASP ASP B . n 
B 1 299 ILE 299 417 417 ILE ILE B . n 
B 1 300 HIS 300 418 418 HIS HIS B . n 
B 1 301 PRO 301 419 419 PRO PRO B . n 
B 1 302 PHE 302 420 420 PHE PHE B . n 
B 1 303 ALA 303 421 421 ALA ALA B . n 
B 1 304 THR 304 422 422 THR THR B . n 
B 1 305 PRO 305 423 423 PRO PRO B . n 
B 1 306 LEU 306 424 424 LEU LEU B . n 
B 1 307 MET 307 425 425 MET MET B . n 
B 1 308 GLN 308 426 426 GLN GLN B . n 
B 1 309 GLU 309 427 427 GLU GLU B . n 
B 1 310 LEU 310 428 428 LEU LEU B . n 
B 1 311 PHE 311 429 429 PHE PHE B . n 
B 1 312 GLY 312 430 430 GLY GLY B . n 
B 1 313 ILE 313 431 431 ILE ILE B . n 
B 1 314 THR 314 432 432 THR THR B . n 
B 1 315 GLY 315 433 ?   ?   ?   B . n 
B 1 316 SER 316 434 ?   ?   ?   B . n 
B 1 317 LEU 317 435 ?   ?   ?   B . n 
B 1 318 VAL 318 436 ?   ?   ?   B . n 
B 1 319 PRO 319 437 ?   ?   ?   B . n 
B 1 320 ARG 320 438 ?   ?   ?   B . n 
B 1 321 GLY 321 439 ?   ?   ?   B . n 
B 1 322 SER 322 440 ?   ?   ?   B . n 
B 1 323 SER 323 441 ?   ?   ?   B . n 
B 1 324 SER 324 442 ?   ?   ?   B . n 
B 1 325 HIS 325 443 ?   ?   ?   B . n 
B 1 326 SER 326 444 ?   ?   ?   B . n 
B 1 327 SER 327 445 ?   ?   ?   B . n 
B 1 328 LEU 328 446 446 LEU LEU B . n 
B 1 329 THR 329 447 447 THR THR B . n 
B 1 330 GLU 330 448 448 GLU GLU B . n 
B 1 331 ARG 331 449 449 ARG ARG B . n 
B 1 332 HIS 332 450 450 HIS HIS B . n 
B 1 333 LYS 333 451 451 LYS LYS B . n 
B 1 334 ILE 334 452 452 ILE ILE B . n 
B 1 335 LEU 335 453 453 LEU LEU B . n 
B 1 336 HIS 336 454 454 HIS HIS B . n 
B 1 337 ARG 337 455 455 ARG ARG B . n 
B 1 338 LEU 338 456 456 LEU LEU B . n 
B 1 339 LEU 339 457 457 LEU LEU B . n 
B 1 340 GLN 340 458 458 GLN GLN B . n 
B 1 341 GLU 341 459 459 GLU GLU B . n 
B 1 342 GLY 342 460 460 GLY GLY B . n 
B 1 343 SER 343 461 461 SER SER B . n 
B 1 344 PRO 344 462 ?   ?   ?   B . n 
B 1 345 SER 345 463 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SRL 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SRL 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 SRL 1  501 1  SRL SRL A . 
D 2 SRL 1  501 2  SRL SRL B . 
E 3 HOH 1  601 9  HOH HOH A . 
E 3 HOH 2  602 12 HOH HOH A . 
E 3 HOH 3  603 11 HOH HOH A . 
E 3 HOH 4  604 7  HOH HOH A . 
E 3 HOH 5  605 4  HOH HOH A . 
E 3 HOH 6  606 10 HOH HOH A . 
E 3 HOH 7  607 13 HOH HOH A . 
E 3 HOH 8  608 43 HOH HOH A . 
E 3 HOH 9  609 5  HOH HOH A . 
E 3 HOH 10 610 26 HOH HOH A . 
E 3 HOH 11 611 8  HOH HOH A . 
E 3 HOH 12 612 6  HOH HOH A . 
E 3 HOH 13 613 3  HOH HOH A . 
E 3 HOH 14 614 34 HOH HOH A . 
E 3 HOH 15 615 16 HOH HOH A . 
E 3 HOH 16 616 2  HOH HOH A . 
E 3 HOH 17 617 45 HOH HOH A . 
E 3 HOH 18 618 33 HOH HOH A . 
E 3 HOH 19 619 41 HOH HOH A . 
F 3 HOH 1  601 20 HOH HOH B . 
F 3 HOH 2  602 18 HOH HOH B . 
F 3 HOH 3  603 28 HOH HOH B . 
F 3 HOH 4  604 47 HOH HOH B . 
F 3 HOH 5  605 19 HOH HOH B . 
F 3 HOH 6  606 37 HOH HOH B . 
F 3 HOH 7  607 32 HOH HOH B . 
F 3 HOH 8  608 42 HOH HOH B . 
F 3 HOH 9  609 39 HOH HOH B . 
F 3 HOH 10 610 21 HOH HOH B . 
F 3 HOH 11 611 35 HOH HOH B . 
F 3 HOH 12 612 29 HOH HOH B . 
F 3 HOH 13 613 48 HOH HOH B . 
F 3 HOH 14 614 22 HOH HOH B . 
F 3 HOH 15 615 30 HOH HOH B . 
F 3 HOH 16 616 40 HOH HOH B . 
F 3 HOH 17 617 23 HOH HOH B . 
F 3 HOH 18 618 25 HOH HOH B . 
F 3 HOH 19 619 46 HOH HOH B . 
F 3 HOH 20 620 44 HOH HOH B . 
F 3 HOH 21 621 31 HOH HOH B . 
F 3 HOH 22 622 27 HOH HOH B . 
F 3 HOH 23 623 24 HOH HOH B . 
F 3 HOH 24 624 36 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A GLN 141 ? CG  ? A GLN 23  CG  
2   1 Y 1 A GLN 141 ? CD  ? A GLN 23  CD  
3   1 Y 1 A GLN 141 ? OE1 ? A GLN 23  OE1 
4   1 Y 1 A GLN 141 ? NE2 ? A GLN 23  NE2 
5   1 Y 1 A GLU 146 ? CG  ? A GLU 28  CG  
6   1 Y 1 A GLU 146 ? CD  ? A GLU 28  CD  
7   1 Y 1 A GLU 146 ? OE1 ? A GLU 28  OE1 
8   1 Y 1 A GLU 146 ? OE2 ? A GLU 28  OE2 
9   1 Y 1 A ARG 152 ? CD  ? A ARG 34  CD  
10  1 Y 1 A ARG 152 ? NE  ? A ARG 34  NE  
11  1 Y 1 A ARG 152 ? CZ  ? A ARG 34  CZ  
12  1 Y 1 A ARG 152 ? NH1 ? A ARG 34  NH1 
13  1 Y 1 A ARG 152 ? NH2 ? A ARG 34  NH2 
14  1 Y 1 A LYS 160 ? NZ  ? A LYS 42  NZ  
15  1 Y 1 A LYS 170 ? CD  ? A LYS 52  CD  
16  1 Y 1 A LYS 170 ? CE  ? A LYS 52  CE  
17  1 Y 1 A LYS 170 ? NZ  ? A LYS 52  NZ  
18  1 Y 1 A ARG 193 ? CG  ? A ARG 75  CG  
19  1 Y 1 A ARG 193 ? CD  ? A ARG 75  CD  
20  1 Y 1 A ARG 193 ? NE  ? A ARG 75  NE  
21  1 Y 1 A ARG 193 ? CZ  ? A ARG 75  CZ  
22  1 Y 1 A ARG 193 ? NH1 ? A ARG 75  NH1 
23  1 Y 1 A ARG 193 ? NH2 ? A ARG 75  NH2 
24  1 Y 1 A GLU 194 ? CG  ? A GLU 76  CG  
25  1 Y 1 A GLU 194 ? CD  ? A GLU 76  CD  
26  1 Y 1 A GLU 194 ? OE1 ? A GLU 76  OE1 
27  1 Y 1 A GLU 194 ? OE2 ? A GLU 76  OE2 
28  1 Y 1 A LYS 204 ? CD  ? A LYS 86  CD  
29  1 Y 1 A LYS 204 ? CE  ? A LYS 86  CE  
30  1 Y 1 A LYS 204 ? NZ  ? A LYS 86  NZ  
31  1 Y 1 A LYS 210 ? CG  ? A LYS 92  CG  
32  1 Y 1 A LYS 210 ? CD  ? A LYS 92  CD  
33  1 Y 1 A LYS 210 ? CE  ? A LYS 92  CE  
34  1 Y 1 A LYS 210 ? NZ  ? A LYS 92  NZ  
35  1 Y 1 A GLU 218 ? CD  ? A GLU 100 CD  
36  1 Y 1 A GLU 218 ? OE1 ? A GLU 100 OE1 
37  1 Y 1 A GLU 218 ? OE2 ? A GLU 100 OE2 
38  1 Y 1 A LYS 226 ? CG  ? A LYS 108 CG  
39  1 Y 1 A LYS 226 ? CD  ? A LYS 108 CD  
40  1 Y 1 A LYS 226 ? CE  ? A LYS 108 CE  
41  1 Y 1 A LYS 226 ? NZ  ? A LYS 108 NZ  
42  1 Y 1 A SER 231 ? OG  ? A SER 113 OG  
43  1 Y 1 A LYS 234 ? CG  ? A LYS 116 CG  
44  1 Y 1 A LYS 234 ? CD  ? A LYS 116 CD  
45  1 Y 1 A LYS 234 ? CE  ? A LYS 116 CE  
46  1 Y 1 A LYS 234 ? NZ  ? A LYS 116 NZ  
47  1 Y 1 A LYS 252 ? CE  ? A LYS 134 CE  
48  1 Y 1 A LYS 252 ? NZ  ? A LYS 134 NZ  
49  1 Y 1 A GLU 270 ? CD  ? A GLU 152 CD  
50  1 Y 1 A GLU 270 ? OE1 ? A GLU 152 OE1 
51  1 Y 1 A GLU 270 ? OE2 ? A GLU 152 OE2 
52  1 Y 1 A GLU 295 ? CD  ? A GLU 177 CD  
53  1 Y 1 A GLU 295 ? OE1 ? A GLU 177 OE1 
54  1 Y 1 A GLU 295 ? OE2 ? A GLU 177 OE2 
55  1 Y 1 A ARG 303 ? CG  ? A ARG 185 CG  
56  1 Y 1 A ARG 303 ? CD  ? A ARG 185 CD  
57  1 Y 1 A ARG 303 ? NE  ? A ARG 185 NE  
58  1 Y 1 A ARG 303 ? CZ  ? A ARG 185 CZ  
59  1 Y 1 A ARG 303 ? NH1 ? A ARG 185 NH1 
60  1 Y 1 A ARG 303 ? NH2 ? A ARG 185 NH2 
61  1 Y 1 A GLU 309 ? CG  ? A GLU 191 CG  
62  1 Y 1 A GLU 309 ? CD  ? A GLU 191 CD  
63  1 Y 1 A GLU 309 ? OE1 ? A GLU 191 OE1 
64  1 Y 1 A GLU 309 ? OE2 ? A GLU 191 OE2 
65  1 Y 1 A ASP 310 ? CG  ? A ASP 192 CG  
66  1 Y 1 A ASP 310 ? OD1 ? A ASP 192 OD1 
67  1 Y 1 A ASP 310 ? OD2 ? A ASP 192 OD2 
68  1 Y 1 A THR 311 ? OG1 ? A THR 193 OG1 
69  1 Y 1 A THR 311 ? CG2 ? A THR 193 CG2 
70  1 Y 1 A PHE 315 ? CG  ? A PHE 197 CG  
71  1 Y 1 A PHE 315 ? CD1 ? A PHE 197 CD1 
72  1 Y 1 A PHE 315 ? CD2 ? A PHE 197 CD2 
73  1 Y 1 A PHE 315 ? CE1 ? A PHE 197 CE1 
74  1 Y 1 A PHE 315 ? CE2 ? A PHE 197 CE2 
75  1 Y 1 A PHE 315 ? CZ  ? A PHE 197 CZ  
76  1 Y 1 A GLN 316 ? CG  ? A GLN 198 CG  
77  1 Y 1 A GLN 316 ? CD  ? A GLN 198 CD  
78  1 Y 1 A GLN 316 ? OE1 ? A GLN 198 OE1 
79  1 Y 1 A GLN 316 ? NE2 ? A GLN 198 NE2 
80  1 Y 1 A GLN 317 ? CG  ? A GLN 199 CG  
81  1 Y 1 A GLN 317 ? CD  ? A GLN 199 CD  
82  1 Y 1 A GLN 317 ? OE1 ? A GLN 199 OE1 
83  1 Y 1 A GLN 317 ? NE2 ? A GLN 199 NE2 
84  1 Y 1 A LEU 318 ? CG  ? A LEU 200 CG  
85  1 Y 1 A LEU 318 ? CD1 ? A LEU 200 CD1 
86  1 Y 1 A LEU 318 ? CD2 ? A LEU 200 CD2 
87  1 Y 1 A LEU 319 ? CG  ? A LEU 201 CG  
88  1 Y 1 A LEU 319 ? CD1 ? A LEU 201 CD1 
89  1 Y 1 A LEU 319 ? CD2 ? A LEU 201 CD2 
90  1 Y 1 A LYS 325 ? CE  ? A LYS 207 CE  
91  1 Y 1 A LYS 325 ? NZ  ? A LYS 207 NZ  
92  1 Y 1 A LYS 332 ? CD  ? A LYS 214 CD  
93  1 Y 1 A LYS 332 ? CE  ? A LYS 214 CE  
94  1 Y 1 A LYS 332 ? NZ  ? A LYS 214 NZ  
95  1 Y 1 A ARG 360 ? CD  ? A ARG 242 CD  
96  1 Y 1 A ARG 360 ? NE  ? A ARG 242 NE  
97  1 Y 1 A ARG 360 ? CZ  ? A ARG 242 CZ  
98  1 Y 1 A ARG 360 ? NH1 ? A ARG 242 NH1 
99  1 Y 1 A ARG 360 ? NH2 ? A ARG 242 NH2 
100 1 Y 1 A GLN 364 ? CD  ? A GLN 246 CD  
101 1 Y 1 A GLN 364 ? OE1 ? A GLN 246 OE1 
102 1 Y 1 A GLN 364 ? NE2 ? A GLN 246 NE2 
103 1 Y 1 A GLN 368 ? CG  ? A GLN 250 CG  
104 1 Y 1 A GLN 368 ? CD  ? A GLN 250 CD  
105 1 Y 1 A GLN 368 ? OE1 ? A GLN 250 OE1 
106 1 Y 1 A GLN 368 ? NE2 ? A GLN 250 NE2 
107 1 Y 1 A CYS 379 ? SG  ? A CYS 261 SG  
108 1 Y 1 A GLN 383 ? CG  ? A GLN 265 CG  
109 1 Y 1 A GLN 383 ? CD  ? A GLN 265 CD  
110 1 Y 1 A GLN 383 ? OE1 ? A GLN 265 OE1 
111 1 Y 1 A GLN 383 ? NE2 ? A GLN 265 NE2 
112 1 Y 1 A GLN 406 ? CD  ? A GLN 288 CD  
113 1 Y 1 A GLN 406 ? OE1 ? A GLN 288 OE1 
114 1 Y 1 A GLN 406 ? NE2 ? A GLN 288 NE2 
115 1 Y 1 A LEU 446 ? CG  ? A LEU 328 CG  
116 1 Y 1 A LEU 446 ? CD1 ? A LEU 328 CD1 
117 1 Y 1 A LEU 446 ? CD2 ? A LEU 328 CD2 
118 1 Y 1 A GLU 448 ? CG  ? A GLU 330 CG  
119 1 Y 1 A GLU 448 ? CD  ? A GLU 330 CD  
120 1 Y 1 A GLU 448 ? OE1 ? A GLU 330 OE1 
121 1 Y 1 A GLU 448 ? OE2 ? A GLU 330 OE2 
122 1 Y 1 A ARG 449 ? CG  ? A ARG 331 CG  
123 1 Y 1 A ARG 449 ? CD  ? A ARG 331 CD  
124 1 Y 1 A ARG 449 ? NE  ? A ARG 331 NE  
125 1 Y 1 A ARG 449 ? CZ  ? A ARG 331 CZ  
126 1 Y 1 A ARG 449 ? NH1 ? A ARG 331 NH1 
127 1 Y 1 A ARG 449 ? NH2 ? A ARG 331 NH2 
128 1 Y 1 A LYS 451 ? CE  ? A LYS 333 CE  
129 1 Y 1 A LYS 451 ? NZ  ? A LYS 333 NZ  
130 1 Y 1 A GLN 458 ? CG  ? A GLN 340 CG  
131 1 Y 1 A GLN 458 ? CD  ? A GLN 340 CD  
132 1 Y 1 A GLN 458 ? OE1 ? A GLN 340 OE1 
133 1 Y 1 A GLN 458 ? NE2 ? A GLN 340 NE2 
134 1 Y 1 B GLU 146 ? CG  ? B GLU 28  CG  
135 1 Y 1 B GLU 146 ? CD  ? B GLU 28  CD  
136 1 Y 1 B GLU 146 ? OE1 ? B GLU 28  OE1 
137 1 Y 1 B GLU 146 ? OE2 ? B GLU 28  OE2 
138 1 Y 1 B MET 149 ? CG  ? B MET 31  CG  
139 1 Y 1 B MET 149 ? SD  ? B MET 31  SD  
140 1 Y 1 B MET 149 ? CE  ? B MET 31  CE  
141 1 Y 1 B ARG 152 ? CD  ? B ARG 34  CD  
142 1 Y 1 B ARG 152 ? NE  ? B ARG 34  NE  
143 1 Y 1 B ARG 152 ? CZ  ? B ARG 34  CZ  
144 1 Y 1 B ARG 152 ? NH1 ? B ARG 34  NH1 
145 1 Y 1 B ARG 152 ? NH2 ? B ARG 34  NH2 
146 1 Y 1 B LYS 170 ? CE  ? B LYS 52  CE  
147 1 Y 1 B LYS 170 ? NZ  ? B LYS 52  NZ  
148 1 Y 1 B GLU 195 ? CG  ? B GLU 77  CG  
149 1 Y 1 B GLU 195 ? CD  ? B GLU 77  CD  
150 1 Y 1 B GLU 195 ? OE1 ? B GLU 77  OE1 
151 1 Y 1 B GLU 195 ? OE2 ? B GLU 77  OE2 
152 1 Y 1 B LYS 198 ? CG  ? B LYS 80  CG  
153 1 Y 1 B LYS 198 ? CD  ? B LYS 80  CD  
154 1 Y 1 B LYS 198 ? CE  ? B LYS 80  CE  
155 1 Y 1 B LYS 198 ? NZ  ? B LYS 80  NZ  
156 1 Y 1 B GLN 201 ? OE1 ? B GLN 83  OE1 
157 1 Y 1 B GLN 201 ? NE2 ? B GLN 83  NE2 
158 1 Y 1 B ARG 203 ? CG  ? B ARG 85  CG  
159 1 Y 1 B ARG 203 ? CD  ? B ARG 85  CD  
160 1 Y 1 B ARG 203 ? NE  ? B ARG 85  NE  
161 1 Y 1 B ARG 203 ? CZ  ? B ARG 85  CZ  
162 1 Y 1 B ARG 203 ? NH1 ? B ARG 85  NH1 
163 1 Y 1 B ARG 203 ? NH2 ? B ARG 85  NH2 
164 1 Y 1 B LYS 204 ? CG  ? B LYS 86  CG  
165 1 Y 1 B LYS 204 ? CD  ? B LYS 86  CD  
166 1 Y 1 B LYS 204 ? CE  ? B LYS 86  CE  
167 1 Y 1 B LYS 204 ? NZ  ? B LYS 86  NZ  
168 1 Y 1 B LYS 210 ? CG  ? B LYS 92  CG  
169 1 Y 1 B LYS 210 ? CD  ? B LYS 92  CD  
170 1 Y 1 B LYS 210 ? CE  ? B LYS 92  CE  
171 1 Y 1 B LYS 210 ? NZ  ? B LYS 92  NZ  
172 1 Y 1 B GLU 218 ? CG  ? B GLU 100 CG  
173 1 Y 1 B GLU 218 ? CD  ? B GLU 100 CD  
174 1 Y 1 B GLU 218 ? OE1 ? B GLU 100 OE1 
175 1 Y 1 B GLU 218 ? OE2 ? B GLU 100 OE2 
176 1 Y 1 B LYS 226 ? CD  ? B LYS 108 CD  
177 1 Y 1 B LYS 226 ? CE  ? B LYS 108 CE  
178 1 Y 1 B LYS 226 ? NZ  ? B LYS 108 NZ  
179 1 Y 1 B SER 231 ? OG  ? B SER 113 OG  
180 1 Y 1 B LYS 234 ? CG  ? B LYS 116 CG  
181 1 Y 1 B LYS 234 ? CD  ? B LYS 116 CD  
182 1 Y 1 B LYS 234 ? CE  ? B LYS 116 CE  
183 1 Y 1 B LYS 234 ? NZ  ? B LYS 116 NZ  
184 1 Y 1 B LYS 277 ? NZ  ? B LYS 159 NZ  
185 1 Y 1 B GLU 295 ? CG  ? B GLU 177 CG  
186 1 Y 1 B GLU 295 ? CD  ? B GLU 177 CD  
187 1 Y 1 B GLU 295 ? OE1 ? B GLU 177 OE1 
188 1 Y 1 B GLU 295 ? OE2 ? B GLU 177 OE2 
189 1 Y 1 B ARG 303 ? CG  ? B ARG 185 CG  
190 1 Y 1 B ARG 303 ? CD  ? B ARG 185 CD  
191 1 Y 1 B ARG 303 ? NE  ? B ARG 185 NE  
192 1 Y 1 B ARG 303 ? CZ  ? B ARG 185 CZ  
193 1 Y 1 B ARG 303 ? NH1 ? B ARG 185 NH1 
194 1 Y 1 B ARG 303 ? NH2 ? B ARG 185 NH2 
195 1 Y 1 B GLU 309 ? CG  ? B GLU 191 CG  
196 1 Y 1 B GLU 309 ? CD  ? B GLU 191 CD  
197 1 Y 1 B GLU 309 ? OE1 ? B GLU 191 OE1 
198 1 Y 1 B GLU 309 ? OE2 ? B GLU 191 OE2 
199 1 Y 1 B ASP 310 ? CG  ? B ASP 192 CG  
200 1 Y 1 B ASP 310 ? OD1 ? B ASP 192 OD1 
201 1 Y 1 B ASP 310 ? OD2 ? B ASP 192 OD2 
202 1 Y 1 B PHE 315 ? CG  ? B PHE 197 CG  
203 1 Y 1 B PHE 315 ? CD1 ? B PHE 197 CD1 
204 1 Y 1 B PHE 315 ? CD2 ? B PHE 197 CD2 
205 1 Y 1 B PHE 315 ? CE1 ? B PHE 197 CE1 
206 1 Y 1 B PHE 315 ? CE2 ? B PHE 197 CE2 
207 1 Y 1 B PHE 315 ? CZ  ? B PHE 197 CZ  
208 1 Y 1 B GLN 316 ? CG  ? B GLN 198 CG  
209 1 Y 1 B GLN 316 ? CD  ? B GLN 198 CD  
210 1 Y 1 B GLN 316 ? OE1 ? B GLN 198 OE1 
211 1 Y 1 B GLN 316 ? NE2 ? B GLN 198 NE2 
212 1 Y 1 B GLN 317 ? CG  ? B GLN 199 CG  
213 1 Y 1 B GLN 317 ? CD  ? B GLN 199 CD  
214 1 Y 1 B GLN 317 ? OE1 ? B GLN 199 OE1 
215 1 Y 1 B GLN 317 ? NE2 ? B GLN 199 NE2 
216 1 Y 1 B LEU 318 ? CG  ? B LEU 200 CG  
217 1 Y 1 B LEU 318 ? CD1 ? B LEU 200 CD1 
218 1 Y 1 B LEU 318 ? CD2 ? B LEU 200 CD2 
219 1 Y 1 B LEU 319 ? CG  ? B LEU 201 CG  
220 1 Y 1 B LEU 319 ? CD1 ? B LEU 201 CD1 
221 1 Y 1 B LEU 319 ? CD2 ? B LEU 201 CD2 
222 1 Y 1 B LYS 325 ? CD  ? B LYS 207 CD  
223 1 Y 1 B LYS 325 ? CE  ? B LYS 207 CE  
224 1 Y 1 B LYS 325 ? NZ  ? B LYS 207 NZ  
225 1 Y 1 B LYS 332 ? CE  ? B LYS 214 CE  
226 1 Y 1 B LYS 332 ? NZ  ? B LYS 214 NZ  
227 1 Y 1 B ARG 360 ? CG  ? B ARG 242 CG  
228 1 Y 1 B ARG 360 ? CD  ? B ARG 242 CD  
229 1 Y 1 B ARG 360 ? NE  ? B ARG 242 NE  
230 1 Y 1 B ARG 360 ? CZ  ? B ARG 242 CZ  
231 1 Y 1 B ARG 360 ? NH1 ? B ARG 242 NH1 
232 1 Y 1 B ARG 360 ? NH2 ? B ARG 242 NH2 
233 1 Y 1 B GLN 364 ? CG  ? B GLN 246 CG  
234 1 Y 1 B GLN 364 ? CD  ? B GLN 246 CD  
235 1 Y 1 B GLN 364 ? OE1 ? B GLN 246 OE1 
236 1 Y 1 B GLN 364 ? NE2 ? B GLN 246 NE2 
237 1 Y 1 B LYS 374 ? NZ  ? B LYS 256 NZ  
238 1 Y 1 B GLN 383 ? CG  ? B GLN 265 CG  
239 1 Y 1 B GLN 383 ? CD  ? B GLN 265 CD  
240 1 Y 1 B GLN 383 ? OE1 ? B GLN 265 OE1 
241 1 Y 1 B GLN 383 ? NE2 ? B GLN 265 NE2 
242 1 Y 1 B GLN 406 ? CD  ? B GLN 288 CD  
243 1 Y 1 B GLN 406 ? OE1 ? B GLN 288 OE1 
244 1 Y 1 B GLN 406 ? NE2 ? B GLN 288 NE2 
245 1 Y 1 B GLN 409 ? CD  ? B GLN 291 CD  
246 1 Y 1 B GLN 409 ? OE1 ? B GLN 291 OE1 
247 1 Y 1 B GLN 409 ? NE2 ? B GLN 291 NE2 
248 1 Y 1 B ILE 417 ? CG1 ? B ILE 299 CG1 
249 1 Y 1 B ILE 417 ? CG2 ? B ILE 299 CG2 
250 1 Y 1 B ILE 417 ? CD1 ? B ILE 299 CD1 
251 1 Y 1 B GLU 448 ? CG  ? B GLU 330 CG  
252 1 Y 1 B GLU 448 ? CD  ? B GLU 330 CD  
253 1 Y 1 B GLU 448 ? OE1 ? B GLU 330 OE1 
254 1 Y 1 B GLU 448 ? OE2 ? B GLU 330 OE2 
255 1 Y 1 B LYS 451 ? CD  ? B LYS 333 CD  
256 1 Y 1 B LYS 451 ? CE  ? B LYS 333 CE  
257 1 Y 1 B LYS 451 ? NZ  ? B LYS 333 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.18.2_3874 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FZI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     85.420 
_cell.length_a_esd                 ? 
_cell.length_b                     89.030 
_cell.length_b_esd                 ? 
_cell.length_c                     106.660 
_cell.length_c_esd                 ? 
_cell.volume                       811143.177 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FZI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FZI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.57 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.11 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;100 mM Imidazole
25 - 30% MPD
;
_exptl_crystal_grow.pdbx_pH_range   '7.0 - 7.4' 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-02-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.967697 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-3' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.967697 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-3 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          55.75 
_reflns.entry_id                                       9FZI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.70 
_reflns.d_resolution_low                               44.51 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22821 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.98 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.103 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.70 
_reflns_shell.d_res_low                                     2.77 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.7 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1689 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               7.2 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.851 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.8 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               0.581 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               53.66 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FZI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.70 
_refine.ls_d_res_low                             44.51 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22821 
_refine.ls_number_reflns_R_free                  1142 
_refine.ls_number_reflns_R_work                  21679 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.33 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1958 
_refine.ls_R_factor_R_free                       0.2371 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1936 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.4350 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3191 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.70 
_refine_hist.d_res_low                        44.51 
_refine_hist.number_atoms_solvent             43 
_refine_hist.number_atoms_total               4564 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4455 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         66 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0087  ? 4674 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0962  ? 6345 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0577  ? 709  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0055  ? 797  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 20.9291 ? 1755 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.70 2.82  . . 141 2679 99.72 . . . . 0.2641 . . . . . . . . . . . 0.3184 
'X-RAY DIFFRACTION' 2.82 2.97  . . 142 2686 99.65 . . . . 0.2350 . . . . . . . . . . . 0.2972 
'X-RAY DIFFRACTION' 2.97 3.16  . . 141 2680 99.47 . . . . 0.2201 . . . . . . . . . . . 0.2890 
'X-RAY DIFFRACTION' 3.16 3.40  . . 140 2673 99.58 . . . . 0.2187 . . . . . . . . . . . 0.2651 
'X-RAY DIFFRACTION' 3.40 3.74  . . 143 2705 99.89 . . . . 0.1819 . . . . . . . . . . . 0.2343 
'X-RAY DIFFRACTION' 3.74 4.28  . . 139 2641 96.63 . . . . 0.1687 . . . . . . . . . . . 0.2141 
'X-RAY DIFFRACTION' 4.29 5.40  . . 144 2736 99.93 . . . . 0.1651 . . . . . . . . . . . 0.1800 
'X-RAY DIFFRACTION' 5.40 44.51 . . 152 2879 99.74 . . . . 0.2007 . . . . . . . . . . . 0.2494 
# 
_struct.entry_id                     9FZI 
_struct.title                        
'A new crystal structure of the hPXR-LBD in fusion with an SRC1 co-activator peptide and in complex with SR12813 (P212121 form)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FZI 
_struct_keywords.text            'nuclear receptor, ligand binding domain, PXR, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP NR1I2_HUMAN O75469 ? 1 
;SERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSL
KVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFN
TVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQF
AITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
;
130 
2 UNP NCOA1_HUMAN Q15788 ? 1 SSHSSLTERHKILHRLLQEGSPS 678 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9FZI A 12  ? 316 ? O75469 130 ? 434 ? 130 434 
2 2 9FZI A 323 ? 345 ? Q15788 678 ? 700 ? 441 463 
3 1 9FZI B 12  ? 316 ? O75469 130 ? 434 ? 130 434 
4 2 9FZI B 323 ? 345 ? Q15788 678 ? 700 ? 441 463 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FZI MET A 1   ? UNP O75469 ? ? 'initiating methionine' 119 1  
1 9FZI LYS A 2   ? UNP O75469 ? ? 'expression tag'        120 2  
1 9FZI LYS A 3   ? UNP O75469 ? ? 'expression tag'        121 3  
1 9FZI GLY A 4   ? UNP O75469 ? ? 'expression tag'        122 4  
1 9FZI HIS A 5   ? UNP O75469 ? ? 'expression tag'        123 5  
1 9FZI HIS A 6   ? UNP O75469 ? ? 'expression tag'        124 6  
1 9FZI HIS A 7   ? UNP O75469 ? ? 'expression tag'        125 7  
1 9FZI HIS A 8   ? UNP O75469 ? ? 'expression tag'        126 8  
1 9FZI HIS A 9   ? UNP O75469 ? ? 'expression tag'        127 9  
1 9FZI HIS A 10  ? UNP O75469 ? ? 'expression tag'        128 10 
1 9FZI GLY A 11  ? UNP O75469 ? ? 'expression tag'        129 11 
1 9FZI LEU A 317 ? UNP O75469 ? ? linker                  435 12 
1 9FZI VAL A 318 ? UNP O75469 ? ? linker                  436 13 
1 9FZI PRO A 319 ? UNP O75469 ? ? linker                  437 14 
1 9FZI ARG A 320 ? UNP O75469 ? ? linker                  438 15 
1 9FZI GLY A 321 ? UNP O75469 ? ? linker                  439 16 
1 9FZI SER A 322 ? UNP O75469 ? ? linker                  440 17 
3 9FZI MET B 1   ? UNP O75469 ? ? 'initiating methionine' 119 18 
3 9FZI LYS B 2   ? UNP O75469 ? ? 'expression tag'        120 19 
3 9FZI LYS B 3   ? UNP O75469 ? ? 'expression tag'        121 20 
3 9FZI GLY B 4   ? UNP O75469 ? ? 'expression tag'        122 21 
3 9FZI HIS B 5   ? UNP O75469 ? ? 'expression tag'        123 22 
3 9FZI HIS B 6   ? UNP O75469 ? ? 'expression tag'        124 23 
3 9FZI HIS B 7   ? UNP O75469 ? ? 'expression tag'        125 24 
3 9FZI HIS B 8   ? UNP O75469 ? ? 'expression tag'        126 25 
3 9FZI HIS B 9   ? UNP O75469 ? ? 'expression tag'        127 26 
3 9FZI HIS B 10  ? UNP O75469 ? ? 'expression tag'        128 27 
3 9FZI GLY B 11  ? UNP O75469 ? ? 'expression tag'        129 28 
3 9FZI LEU B 317 ? UNP O75469 ? ? linker                  435 29 
3 9FZI VAL B 318 ? UNP O75469 ? ? linker                  436 30 
3 9FZI PRO B 319 ? UNP O75469 ? ? linker                  437 31 
3 9FZI ARG B 320 ? UNP O75469 ? ? linker                  438 32 
3 9FZI GLY B 321 ? UNP O75469 ? ? linker                  439 33 
3 9FZI SER B 322 ? UNP O75469 ? ? linker                  440 34 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,E 
2 1 B,D,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 26  ? PHE A 44  ? THR A 144 PHE A 162 1 ? 19 
HELX_P HELX_P2  AA2 ARG A 75  ? SER A 90  ? ARG A 193 SER A 208 1 ? 16 
HELX_P HELX_P3  AA3 GLY A 115 ? SER A 120 ? GLY A 233 SER A 238 5 ? 6  
HELX_P HELX_P4  AA4 LEU A 121 ? ILE A 143 ? LEU A 239 ILE A 261 1 ? 23 
HELX_P HELX_P5  AA5 ILE A 143 ? ASP A 148 ? ILE A 261 ASP A 266 1 ? 6  
HELX_P HELX_P6  AA6 PRO A 150 ? THR A 172 ? PRO A 268 THR A 290 1 ? 23 
HELX_P HELX_P7  AA7 GLN A 199 ? LEU A 202 ? GLN A 317 LEU A 320 5 ? 4  
HELX_P HELX_P8  AA8 GLU A 203 ? GLN A 216 ? GLU A 321 GLN A 334 1 ? 14 
HELX_P HELX_P9  AA9 HIS A 218 ? PHE A 231 ? HIS A 336 PHE A 349 1 ? 14 
HELX_P HELX_P10 AB1 GLN A 240 ? ARG A 263 ? GLN A 358 ARG A 381 1 ? 24 
HELX_P HELX_P11 AB2 PHE A 270 ? HIS A 300 ? PHE A 388 HIS A 418 1 ? 31 
HELX_P HELX_P12 AB3 THR A 304 ? PHE A 311 ? THR A 422 PHE A 429 1 ? 8  
HELX_P HELX_P13 AB4 HIS A 332 ? GLU A 341 ? HIS A 450 GLU A 459 1 ? 10 
HELX_P HELX_P14 AB5 THR B 26  ? PHE B 44  ? THR B 144 PHE B 162 1 ? 19 
HELX_P HELX_P15 AB6 ALA B 78  ? CYS B 89  ? ALA B 196 CYS B 207 1 ? 12 
HELX_P HELX_P16 AB7 GLY B 115 ? SER B 120 ? GLY B 233 SER B 238 5 ? 6  
HELX_P HELX_P17 AB8 LEU B 121 ? ILE B 143 ? LEU B 239 ILE B 261 1 ? 23 
HELX_P HELX_P18 AB9 ILE B 143 ? ASP B 148 ? ILE B 261 ASP B 266 1 ? 6  
HELX_P HELX_P19 AC1 PRO B 150 ? THR B 172 ? PRO B 268 THR B 290 1 ? 23 
HELX_P HELX_P20 AC2 PHE B 197 ? LEU B 201 ? PHE B 315 LEU B 319 1 ? 5  
HELX_P HELX_P21 AC3 GLU B 203 ? LEU B 215 ? GLU B 321 LEU B 333 1 ? 13 
HELX_P HELX_P22 AC4 HIS B 218 ? PHE B 231 ? HIS B 336 PHE B 349 1 ? 14 
HELX_P HELX_P23 AC5 GLN B 240 ? ARG B 263 ? GLN B 358 ARG B 381 1 ? 24 
HELX_P HELX_P24 AC6 GLN B 265 ? ARG B 269 ? GLN B 383 ARG B 387 5 ? 5  
HELX_P HELX_P25 AC7 PHE B 270 ? HIS B 300 ? PHE B 388 HIS B 418 1 ? 31 
HELX_P HELX_P26 AC8 THR B 304 ? GLY B 312 ? THR B 422 GLY B 430 1 ? 9  
HELX_P HELX_P27 AC9 HIS B 332 ? GLU B 341 ? HIS B 450 GLU B 459 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           265 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            383 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    266 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     384 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -5.74 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   10 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? anti-parallel 
AA1 2 3  ? anti-parallel 
AA1 3 4  ? anti-parallel 
AA1 4 5  ? anti-parallel 
AA1 5 6  ? anti-parallel 
AA1 6 7  ? anti-parallel 
AA1 7 8  ? anti-parallel 
AA1 8 9  ? anti-parallel 
AA1 9 10 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  PHE A 174 ? ASN A 175 ? PHE A 292 ASN A 293 
AA1 2  THR A 180 ? CYS A 183 ? THR A 298 CYS A 301 
AA1 3  LEU A 186 ? LEU A 190 ? LEU A 304 LEU A 308 
AA1 4  VAL A 93  ? ARG A 98  ? VAL A 211 ARG A 216 
AA1 5  VAL A 104 ? LYS A 108 ? VAL A 222 LYS A 226 
AA1 6  VAL B 104 ? LYS B 108 ? VAL B 222 LYS B 226 
AA1 7  VAL B 93  ? ARG B 98  ? VAL B 211 ARG B 216 
AA1 8  LEU B 186 ? LEU B 190 ? LEU B 304 LEU B 308 
AA1 9  THR B 180 ? CYS B 183 ? THR B 298 CYS B 301 
AA1 10 PHE B 174 ? ASN B 175 ? PHE B 292 ASN B 293 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ASN A 175 ? N ASN A 293 O THR A 180 ? O THR A 298 
AA1 2 3  N TRP A 181 ? N TRP A 299 O TYR A 188 ? O TYR A 306 
AA1 3 4  O SER A 187 ? O SER A 305 N GLN A 96  ? N GLN A 214 
AA1 4 5  N LEU A 95  ? N LEU A 213 O TYR A 107 ? O TYR A 225 
AA1 5 6  N VAL A 104 ? N VAL A 222 O LYS B 108 ? O LYS B 226 
AA1 6 7  O TYR B 107 ? O TYR B 225 N LEU B 95  ? N LEU B 213 
AA1 7 8  N GLN B 96  ? N GLN B 214 O SER B 187 ? O SER B 305 
AA1 8 9  O TYR B 188 ? O TYR B 306 N TRP B 181 ? N TRP B 299 
AA1 9 10 O THR B 180 ? O THR B 298 N ASN B 175 ? N ASN B 293 
# 
_pdbx_entry_details.entry_id                   9FZI 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 CYS A 301 ? ? -108.10 68.53  
2  1 LEU A 319 ? ? -64.41  7.26   
3  1 HIS A 386 ? ? -93.26  35.90  
4  1 PHE A 420 ? ? -155.22 -12.41 
5  1 ALA B 196 ? ? -140.83 -20.11 
6  1 LYS B 234 ? ? -66.26  4.77   
7  1 CYS B 301 ? ? -102.18 68.66  
8  1 PHE B 349 ? ? -92.01  58.90  
9  1 ARG B 381 ? ? -115.51 62.08  
10 1 HIS B 418 ? ? -152.79 86.95  
11 1 PHE B 420 ? ? -151.52 -9.33  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 119 ? A MET 1   
2   1 Y 1 A LYS 120 ? A LYS 2   
3   1 Y 1 A LYS 121 ? A LYS 3   
4   1 Y 1 A GLY 122 ? A GLY 4   
5   1 Y 1 A HIS 123 ? A HIS 5   
6   1 Y 1 A HIS 124 ? A HIS 6   
7   1 Y 1 A HIS 125 ? A HIS 7   
8   1 Y 1 A HIS 126 ? A HIS 8   
9   1 Y 1 A HIS 127 ? A HIS 9   
10  1 Y 1 A HIS 128 ? A HIS 10  
11  1 Y 1 A GLY 129 ? A GLY 11  
12  1 Y 1 A SER 130 ? A SER 12  
13  1 Y 1 A GLU 131 ? A GLU 13  
14  1 Y 1 A ARG 132 ? A ARG 14  
15  1 Y 1 A THR 133 ? A THR 15  
16  1 Y 1 A GLY 134 ? A GLY 16  
17  1 Y 1 A THR 135 ? A THR 17  
18  1 Y 1 A GLN 136 ? A GLN 18  
19  1 Y 1 A PRO 137 ? A PRO 19  
20  1 Y 1 A LEU 138 ? A LEU 20  
21  1 Y 1 A GLY 139 ? A GLY 21  
22  1 Y 1 A VAL 140 ? A VAL 22  
23  1 Y 1 A VAL 177 ? A VAL 59  
24  1 Y 1 A LEU 178 ? A LEU 60  
25  1 Y 1 A SER 179 ? A SER 61  
26  1 Y 1 A SER 180 ? A SER 62  
27  1 Y 1 A GLY 181 ? A GLY 63  
28  1 Y 1 A CYS 182 ? A CYS 64  
29  1 Y 1 A GLU 183 ? A GLU 65  
30  1 Y 1 A LEU 184 ? A LEU 66  
31  1 Y 1 A PRO 185 ? A PRO 67  
32  1 Y 1 A GLU 186 ? A GLU 68  
33  1 Y 1 A SER 187 ? A SER 69  
34  1 Y 1 A LEU 188 ? A LEU 70  
35  1 Y 1 A GLN 189 ? A GLN 71  
36  1 Y 1 A ALA 190 ? A ALA 72  
37  1 Y 1 A PRO 191 ? A PRO 73  
38  1 Y 1 A ALA 312 ? A ALA 194 
39  1 Y 1 A GLY 313 ? A GLY 195 
40  1 Y 1 A GLY 314 ? A GLY 196 
41  1 Y 1 A GLY 433 ? A GLY 315 
42  1 Y 1 A SER 434 ? A SER 316 
43  1 Y 1 A LEU 435 ? A LEU 317 
44  1 Y 1 A VAL 436 ? A VAL 318 
45  1 Y 1 A PRO 437 ? A PRO 319 
46  1 Y 1 A ARG 438 ? A ARG 320 
47  1 Y 1 A GLY 439 ? A GLY 321 
48  1 Y 1 A SER 440 ? A SER 322 
49  1 Y 1 A SER 441 ? A SER 323 
50  1 Y 1 A SER 442 ? A SER 324 
51  1 Y 1 A HIS 443 ? A HIS 325 
52  1 Y 1 A SER 444 ? A SER 326 
53  1 Y 1 A SER 461 ? A SER 343 
54  1 Y 1 A PRO 462 ? A PRO 344 
55  1 Y 1 A SER 463 ? A SER 345 
56  1 Y 1 B MET 119 ? B MET 1   
57  1 Y 1 B LYS 120 ? B LYS 2   
58  1 Y 1 B LYS 121 ? B LYS 3   
59  1 Y 1 B GLY 122 ? B GLY 4   
60  1 Y 1 B HIS 123 ? B HIS 5   
61  1 Y 1 B HIS 124 ? B HIS 6   
62  1 Y 1 B HIS 125 ? B HIS 7   
63  1 Y 1 B HIS 126 ? B HIS 8   
64  1 Y 1 B HIS 127 ? B HIS 9   
65  1 Y 1 B HIS 128 ? B HIS 10  
66  1 Y 1 B GLY 129 ? B GLY 11  
67  1 Y 1 B SER 130 ? B SER 12  
68  1 Y 1 B GLU 131 ? B GLU 13  
69  1 Y 1 B ARG 132 ? B ARG 14  
70  1 Y 1 B THR 133 ? B THR 15  
71  1 Y 1 B GLY 134 ? B GLY 16  
72  1 Y 1 B THR 135 ? B THR 17  
73  1 Y 1 B GLN 136 ? B GLN 18  
74  1 Y 1 B PRO 137 ? B PRO 19  
75  1 Y 1 B LEU 138 ? B LEU 20  
76  1 Y 1 B GLY 139 ? B GLY 21  
77  1 Y 1 B VAL 140 ? B VAL 22  
78  1 Y 1 B GLN 141 ? B GLN 23  
79  1 Y 1 B GLY 142 ? B GLY 24  
80  1 Y 1 B VAL 177 ? B VAL 59  
81  1 Y 1 B LEU 178 ? B LEU 60  
82  1 Y 1 B SER 179 ? B SER 61  
83  1 Y 1 B SER 180 ? B SER 62  
84  1 Y 1 B GLY 181 ? B GLY 63  
85  1 Y 1 B CYS 182 ? B CYS 64  
86  1 Y 1 B GLU 183 ? B GLU 65  
87  1 Y 1 B LEU 184 ? B LEU 66  
88  1 Y 1 B PRO 185 ? B PRO 67  
89  1 Y 1 B GLU 186 ? B GLU 68  
90  1 Y 1 B SER 187 ? B SER 69  
91  1 Y 1 B LEU 188 ? B LEU 70  
92  1 Y 1 B GLN 189 ? B GLN 71  
93  1 Y 1 B ALA 190 ? B ALA 72  
94  1 Y 1 B PRO 191 ? B PRO 73  
95  1 Y 1 B SER 192 ? B SER 74  
96  1 Y 1 B ARG 193 ? B ARG 75  
97  1 Y 1 B GLU 194 ? B GLU 76  
98  1 Y 1 B THR 311 ? B THR 193 
99  1 Y 1 B ALA 312 ? B ALA 194 
100 1 Y 1 B GLY 313 ? B GLY 195 
101 1 Y 1 B GLY 433 ? B GLY 315 
102 1 Y 1 B SER 434 ? B SER 316 
103 1 Y 1 B LEU 435 ? B LEU 317 
104 1 Y 1 B VAL 436 ? B VAL 318 
105 1 Y 1 B PRO 437 ? B PRO 319 
106 1 Y 1 B ARG 438 ? B ARG 320 
107 1 Y 1 B GLY 439 ? B GLY 321 
108 1 Y 1 B SER 440 ? B SER 322 
109 1 Y 1 B SER 441 ? B SER 323 
110 1 Y 1 B SER 442 ? B SER 324 
111 1 Y 1 B HIS 443 ? B HIS 325 
112 1 Y 1 B SER 444 ? B SER 326 
113 1 Y 1 B SER 445 ? B SER 327 
114 1 Y 1 B PRO 462 ? B PRO 344 
115 1 Y 1 B SER 463 ? B SER 345 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
SRL C1   C Y N 304 
SRL C2   C Y N 305 
SRL C3   C Y N 306 
SRL C4   C Y N 307 
SRL C5   C Y N 308 
SRL C6   C Y N 309 
SRL C7   C N N 310 
SRL C8   C N N 311 
SRL P9   P N N 312 
SRL P10  P N N 313 
SRL O11  O N N 314 
SRL C12  C N N 315 
SRL C13  C N N 316 
SRL C14  C N N 317 
SRL C15  C N N 318 
SRL C16  C N N 319 
SRL C17  C N N 320 
SRL C18  C N N 321 
SRL C19  C N N 322 
SRL O20  O N N 323 
SRL O21  O N N 324 
SRL C22  C N N 325 
SRL C23  C N N 326 
SRL O24  O N N 327 
SRL C25  C N N 328 
SRL C26  C N N 329 
SRL O27  O N N 330 
SRL O28  O N N 331 
SRL C29  C N N 332 
SRL C30  C N N 333 
SRL O31  O N N 334 
SRL C32  C N N 335 
SRL C33  C N N 336 
SRL HC4  H N N 337 
SRL HC6  H N N 338 
SRL HC7  H N N 339 
SRL H11  H N N 340 
SRL H141 H N N 341 
SRL H142 H N N 342 
SRL H143 H N N 343 
SRL H151 H N N 344 
SRL H152 H N N 345 
SRL H153 H N N 346 
SRL H161 H N N 347 
SRL H162 H N N 348 
SRL H163 H N N 349 
SRL H171 H N N 350 
SRL H172 H N N 351 
SRL H173 H N N 352 
SRL H181 H N N 353 
SRL H182 H N N 354 
SRL H183 H N N 355 
SRL H191 H N N 356 
SRL H192 H N N 357 
SRL H193 H N N 358 
SRL H221 H N N 359 
SRL H222 H N N 360 
SRL H231 H N N 361 
SRL H232 H N N 362 
SRL H233 H N N 363 
SRL H251 H N N 364 
SRL H252 H N N 365 
SRL H261 H N N 366 
SRL H262 H N N 367 
SRL H263 H N N 368 
SRL H291 H N N 369 
SRL H292 H N N 370 
SRL H301 H N N 371 
SRL H302 H N N 372 
SRL H303 H N N 373 
SRL H321 H N N 374 
SRL H322 H N N 375 
SRL H331 H N N 376 
SRL H332 H N N 377 
SRL H333 H N N 378 
THR N    N N N 379 
THR CA   C N S 380 
THR C    C N N 381 
THR O    O N N 382 
THR CB   C N R 383 
THR OG1  O N N 384 
THR CG2  C N N 385 
THR OXT  O N N 386 
THR H    H N N 387 
THR H2   H N N 388 
THR HA   H N N 389 
THR HB   H N N 390 
THR HG1  H N N 391 
THR HG21 H N N 392 
THR HG22 H N N 393 
THR HG23 H N N 394 
THR HXT  H N N 395 
TRP N    N N N 396 
TRP CA   C N S 397 
TRP C    C N N 398 
TRP O    O N N 399 
TRP CB   C N N 400 
TRP CG   C Y N 401 
TRP CD1  C Y N 402 
TRP CD2  C Y N 403 
TRP NE1  N Y N 404 
TRP CE2  C Y N 405 
TRP CE3  C Y N 406 
TRP CZ2  C Y N 407 
TRP CZ3  C Y N 408 
TRP CH2  C Y N 409 
TRP OXT  O N N 410 
TRP H    H N N 411 
TRP H2   H N N 412 
TRP HA   H N N 413 
TRP HB2  H N N 414 
TRP HB3  H N N 415 
TRP HD1  H N N 416 
TRP HE1  H N N 417 
TRP HE3  H N N 418 
TRP HZ2  H N N 419 
TRP HZ3  H N N 420 
TRP HH2  H N N 421 
TRP HXT  H N N 422 
TYR N    N N N 423 
TYR CA   C N S 424 
TYR C    C N N 425 
TYR O    O N N 426 
TYR CB   C N N 427 
TYR CG   C Y N 428 
TYR CD1  C Y N 429 
TYR CD2  C Y N 430 
TYR CE1  C Y N 431 
TYR CE2  C Y N 432 
TYR CZ   C Y N 433 
TYR OH   O N N 434 
TYR OXT  O N N 435 
TYR H    H N N 436 
TYR H2   H N N 437 
TYR HA   H N N 438 
TYR HB2  H N N 439 
TYR HB3  H N N 440 
TYR HD1  H N N 441 
TYR HD2  H N N 442 
TYR HE1  H N N 443 
TYR HE2  H N N 444 
TYR HH   H N N 445 
TYR HXT  H N N 446 
VAL N    N N N 447 
VAL CA   C N S 448 
VAL C    C N N 449 
VAL O    O N N 450 
VAL CB   C N N 451 
VAL CG1  C N N 452 
VAL CG2  C N N 453 
VAL OXT  O N N 454 
VAL H    H N N 455 
VAL H2   H N N 456 
VAL HA   H N N 457 
VAL HB   H N N 458 
VAL HG11 H N N 459 
VAL HG12 H N N 460 
VAL HG13 H N N 461 
VAL HG21 H N N 462 
VAL HG22 H N N 463 
VAL HG23 H N N 464 
VAL HXT  H N N 465 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
SRL C1  C2   doub Y N 290 
SRL C1  C6   sing Y N 291 
SRL C1  C12  sing N N 292 
SRL C2  C3   sing Y N 293 
SRL C2  O11  sing N N 294 
SRL C3  C4   doub Y N 295 
SRL C3  C13  sing N N 296 
SRL C4  C5   sing Y N 297 
SRL C4  HC4  sing N N 298 
SRL C5  C6   doub Y N 299 
SRL C5  C7   sing N N 300 
SRL C6  HC6  sing N N 301 
SRL C7  C8   doub N N 302 
SRL C7  HC7  sing N N 303 
SRL C8  P9   sing N N 304 
SRL C8  P10  sing N N 305 
SRL P9  O20  doub N N 306 
SRL P9  O21  sing N N 307 
SRL P9  O24  sing N N 308 
SRL P10 O27  doub N N 309 
SRL P10 O28  sing N N 310 
SRL P10 O31  sing N N 311 
SRL O11 H11  sing N N 312 
SRL C12 C14  sing N N 313 
SRL C12 C15  sing N N 314 
SRL C12 C16  sing N N 315 
SRL C13 C17  sing N N 316 
SRL C13 C18  sing N N 317 
SRL C13 C19  sing N N 318 
SRL C14 H141 sing N N 319 
SRL C14 H142 sing N N 320 
SRL C14 H143 sing N N 321 
SRL C15 H151 sing N N 322 
SRL C15 H152 sing N N 323 
SRL C15 H153 sing N N 324 
SRL C16 H161 sing N N 325 
SRL C16 H162 sing N N 326 
SRL C16 H163 sing N N 327 
SRL C17 H171 sing N N 328 
SRL C17 H172 sing N N 329 
SRL C17 H173 sing N N 330 
SRL C18 H181 sing N N 331 
SRL C18 H182 sing N N 332 
SRL C18 H183 sing N N 333 
SRL C19 H191 sing N N 334 
SRL C19 H192 sing N N 335 
SRL C19 H193 sing N N 336 
SRL O21 C22  sing N N 337 
SRL C22 C23  sing N N 338 
SRL C22 H221 sing N N 339 
SRL C22 H222 sing N N 340 
SRL C23 H231 sing N N 341 
SRL C23 H232 sing N N 342 
SRL C23 H233 sing N N 343 
SRL O24 C25  sing N N 344 
SRL C25 C26  sing N N 345 
SRL C25 H251 sing N N 346 
SRL C25 H252 sing N N 347 
SRL C26 H261 sing N N 348 
SRL C26 H262 sing N N 349 
SRL C26 H263 sing N N 350 
SRL O28 C29  sing N N 351 
SRL C29 C30  sing N N 352 
SRL C29 H291 sing N N 353 
SRL C29 H292 sing N N 354 
SRL C30 H301 sing N N 355 
SRL C30 H302 sing N N 356 
SRL C30 H303 sing N N 357 
SRL O31 C32  sing N N 358 
SRL C32 C33  sing N N 359 
SRL C32 H321 sing N N 360 
SRL C32 H322 sing N N 361 
SRL C33 H331 sing N N 362 
SRL C33 H332 sing N N 363 
SRL C33 H333 sing N N 364 
THR N   CA   sing N N 365 
THR N   H    sing N N 366 
THR N   H2   sing N N 367 
THR CA  C    sing N N 368 
THR CA  CB   sing N N 369 
THR CA  HA   sing N N 370 
THR C   O    doub N N 371 
THR C   OXT  sing N N 372 
THR CB  OG1  sing N N 373 
THR CB  CG2  sing N N 374 
THR CB  HB   sing N N 375 
THR OG1 HG1  sing N N 376 
THR CG2 HG21 sing N N 377 
THR CG2 HG22 sing N N 378 
THR CG2 HG23 sing N N 379 
THR OXT HXT  sing N N 380 
TRP N   CA   sing N N 381 
TRP N   H    sing N N 382 
TRP N   H2   sing N N 383 
TRP CA  C    sing N N 384 
TRP CA  CB   sing N N 385 
TRP CA  HA   sing N N 386 
TRP C   O    doub N N 387 
TRP C   OXT  sing N N 388 
TRP CB  CG   sing N N 389 
TRP CB  HB2  sing N N 390 
TRP CB  HB3  sing N N 391 
TRP CG  CD1  doub Y N 392 
TRP CG  CD2  sing Y N 393 
TRP CD1 NE1  sing Y N 394 
TRP CD1 HD1  sing N N 395 
TRP CD2 CE2  doub Y N 396 
TRP CD2 CE3  sing Y N 397 
TRP NE1 CE2  sing Y N 398 
TRP NE1 HE1  sing N N 399 
TRP CE2 CZ2  sing Y N 400 
TRP CE3 CZ3  doub Y N 401 
TRP CE3 HE3  sing N N 402 
TRP CZ2 CH2  doub Y N 403 
TRP CZ2 HZ2  sing N N 404 
TRP CZ3 CH2  sing Y N 405 
TRP CZ3 HZ3  sing N N 406 
TRP CH2 HH2  sing N N 407 
TRP OXT HXT  sing N N 408 
TYR N   CA   sing N N 409 
TYR N   H    sing N N 410 
TYR N   H2   sing N N 411 
TYR CA  C    sing N N 412 
TYR CA  CB   sing N N 413 
TYR CA  HA   sing N N 414 
TYR C   O    doub N N 415 
TYR C   OXT  sing N N 416 
TYR CB  CG   sing N N 417 
TYR CB  HB2  sing N N 418 
TYR CB  HB3  sing N N 419 
TYR CG  CD1  doub Y N 420 
TYR CG  CD2  sing Y N 421 
TYR CD1 CE1  sing Y N 422 
TYR CD1 HD1  sing N N 423 
TYR CD2 CE2  doub Y N 424 
TYR CD2 HD2  sing N N 425 
TYR CE1 CZ   doub Y N 426 
TYR CE1 HE1  sing N N 427 
TYR CE2 CZ   sing Y N 428 
TYR CE2 HE2  sing N N 429 
TYR CZ  OH   sing N N 430 
TYR OH  HH   sing N N 431 
TYR OXT HXT  sing N N 432 
VAL N   CA   sing N N 433 
VAL N   H    sing N N 434 
VAL N   H2   sing N N 435 
VAL CA  C    sing N N 436 
VAL CA  CB   sing N N 437 
VAL CA  HA   sing N N 438 
VAL C   O    doub N N 439 
VAL C   OXT  sing N N 440 
VAL CB  CG1  sing N N 441 
VAL CB  CG2  sing N N 442 
VAL CB  HB   sing N N 443 
VAL CG1 HG11 sing N N 444 
VAL CG1 HG12 sing N N 445 
VAL CG1 HG13 sing N N 446 
VAL CG2 HG21 sing N N 447 
VAL CG2 HG22 sing N N 448 
VAL CG2 HG23 sing N N 449 
VAL OXT HXT  sing N N 450 
# 
_pdbx_audit_support.funding_organization   'Agence Nationale de la Recherche (ANR)' 
_pdbx_audit_support.country                France 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1ILG 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FZI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011707 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011232 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009376 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 23  ? -35.58499 25.67787  -58.33729 1.000 91.54000  ? 141 GLN A N   1 
ATOM   2    C CA  . GLN A 1 23  ? -36.41330 25.89481  -57.14632 1.000 91.20000  ? 141 GLN A CA  1 
ATOM   3    C C   . GLN A 1 23  ? -37.87007 25.46032  -57.39884 1.000 92.53000  ? 141 GLN A C   1 
ATOM   4    O O   . GLN A 1 23  ? -38.25066 24.36791  -56.99556 1.000 85.60000  ? 141 GLN A O   1 
ATOM   5    C CB  . GLN A 1 23  ? -36.35303 27.36457  -56.69245 1.000 82.07000  ? 141 GLN A CB  1 
ATOM   6    N N   . GLY A 1 24  ? -38.67732 26.30335  -58.05450 1.000 92.04000  ? 142 GLY A N   1 
ATOM   7    C CA  . GLY A 1 24  ? -40.06711 25.96091  -58.33796 1.000 85.98000  ? 142 GLY A CA  1 
ATOM   8    C C   . GLY A 1 24  ? -41.05942 26.17881  -57.20801 1.000 83.76000  ? 142 GLY A C   1 
ATOM   9    O O   . GLY A 1 24  ? -42.13015 25.55633  -57.20458 1.000 84.02000  ? 142 GLY A O   1 
ATOM   10   N N   . LEU A 1 25  ? -40.73798 27.04538  -56.24944 1.000 80.64000  ? 143 LEU A N   1 
ATOM   11   C CA  . LEU A 1 25  ? -41.58732 27.36134  -55.11041 1.000 71.98000  ? 143 LEU A CA  1 
ATOM   12   C C   . LEU A 1 25  ? -42.10092 28.78421  -55.26067 1.000 69.54000  ? 143 LEU A C   1 
ATOM   13   O O   . LEU A 1 25  ? -41.52813 29.58589  -56.00210 1.000 73.16000  ? 143 LEU A O   1 
ATOM   14   C CB  . LEU A 1 25  ? -40.81252 27.25191  -53.79034 1.000 76.16000  ? 143 LEU A CB  1 
ATOM   15   C CG  . LEU A 1 25  ? -40.34302 25.88880  -53.26205 1.000 68.09000  ? 143 LEU A CG  1 
ATOM   16   C CD1 . LEU A 1 25  ? -39.06069 25.43878  -53.96908 1.000 69.53000  ? 143 LEU A CD1 1 
ATOM   17   C CD2 . LEU A 1 25  ? -40.15931 25.90200  -51.75601 1.000 59.28000  ? 143 LEU A CD2 1 
ATOM   18   N N   . THR A 1 26  ? -43.16820 29.11331  -54.53368 1.000 65.33000  ? 144 THR A N   1 
ATOM   19   C CA  . THR A 1 26  ? -43.66179 30.48412  -54.57296 1.000 65.29000  ? 144 THR A CA  1 
ATOM   20   C C   . THR A 1 26  ? -42.64532 31.40918  -53.91123 1.000 72.73000  ? 144 THR A C   1 
ATOM   21   O O   . THR A 1 26  ? -41.62423 30.98131  -53.37029 1.000 77.77000  ? 144 THR A O   1 
ATOM   22   C CB  . THR A 1 26  ? -44.99199 30.62711  -53.84812 1.000 61.97000  ? 144 THR A CB  1 
ATOM   23   O OG1 . THR A 1 26  ? -44.77119 30.49438  -52.44616 1.000 69.30000  ? 144 THR A OG1 1 
ATOM   24   C CG2 . THR A 1 26  ? -45.93743 29.52494  -54.26595 1.000 65.59000  ? 144 THR A CG2 1 
ATOM   25   N N   . GLU A 1 27  ? -42.92388 32.70307  -53.93052 1.000 75.57000  ? 145 GLU A N   1 
ATOM   26   C CA  . GLU A 1 27  ? -41.97839 33.58409  -53.26683 1.000 72.41000  ? 145 GLU A CA  1 
ATOM   27   C C   . GLU A 1 27  ? -42.14964 33.51813  -51.75390 1.000 66.32000  ? 145 GLU A C   1 
ATOM   28   O O   . GLU A 1 27  ? -41.15779 33.53613  -51.01871 1.000 66.06000  ? 145 GLU A O   1 
ATOM   29   C CB  . GLU A 1 27  ? -42.11993 35.02033  -53.78101 1.000 77.15000  ? 145 GLU A CB  1 
ATOM   30   C CG  . GLU A 1 27  ? -40.91337 35.90667  -53.46527 1.000 82.05000  ? 145 GLU A CG  1 
ATOM   31   C CD  . GLU A 1 27  ? -39.58202 35.30654  -53.94238 1.000 91.10000  ? 145 GLU A CD  1 
ATOM   32   O OE1 . GLU A 1 27  ? -39.58847 34.43206  -54.84089 1.000 93.82000  ? 145 GLU A OE1 1 
ATOM   33   O OE2 . GLU A 1 27  ? -38.52029 35.70269  -53.41195 1.000 91.61000  ? 145 GLU A OE2 1 
ATOM   34   N N   . GLU A 1 28  ? -43.39369 33.42630  -51.26718 1.000 65.68000  ? 146 GLU A N   1 
ATOM   35   C CA  . GLU A 1 28  ? -43.60388 33.24836  -49.83533 1.000 64.51000  ? 146 GLU A CA  1 
ATOM   36   C C   . GLU A 1 28  ? -42.82745 32.04540  -49.31889 1.000 70.16000  ? 146 GLU A C   1 
ATOM   37   O O   . GLU A 1 28  ? -42.32966 32.05895  -48.18779 1.000 68.72000  ? 146 GLU A O   1 
ATOM   38   C CB  . GLU A 1 28  ? -45.09086 33.07553  -49.53170 1.000 56.81000  ? 146 GLU A CB  1 
ATOM   39   N N   . GLN A 1 29  ? -42.68584 31.01295  -50.15147 1.000 66.37000  ? 147 GLN A N   1 
ATOM   40   C CA  . GLN A 1 29  ? -42.06537 29.76797  -49.72709 1.000 63.90000  ? 147 GLN A CA  1 
ATOM   41   C C   . GLN A 1 29  ? -40.54742 29.87763  -49.71774 1.000 65.07000  ? 147 GLN A C   1 
ATOM   42   O O   . GLN A 1 29  ? -39.90443 29.48634  -48.73885 1.000 64.57000  ? 147 GLN A O   1 
ATOM   43   C CB  . GLN A 1 29  ? -42.52970 28.61830  -50.62985 1.000 60.57000  ? 147 GLN A CB  1 
ATOM   44   C CG  . GLN A 1 29  ? -44.01258 28.25053  -50.42934 1.000 58.26000  ? 147 GLN A CG  1 
ATOM   45   C CD  . GLN A 1 29  ? -44.51894 27.19889  -51.41605 1.000 58.90000  ? 147 GLN A CD  1 
ATOM   46   O OE1 . GLN A 1 29  ? -44.05969 27.12076  -52.56501 1.000 57.48000  ? 147 GLN A OE1 1 
ATOM   47   N NE2 . GLN A 1 29  ? -45.48166 26.38620  -50.96771 1.000 59.32000  ? 147 GLN A NE2 1 
ATOM   48   N N   . ARG A 1 30  ? -39.95445 30.39453  -50.80033 1.000 69.52000  ? 148 ARG A N   1 
ATOM   49   C CA  . ARG A 1 30  ? -38.50954 30.60717  -50.81094 1.000 63.80000  ? 148 ARG A CA  1 
ATOM   50   C C   . ARG A 1 30  ? -38.06314 31.48868  -49.65034 1.000 65.90000  ? 148 ARG A C   1 
ATOM   51   O O   . ARG A 1 30  ? -36.97416 31.28883  -49.09625 1.000 63.60000  ? 148 ARG A O   1 
ATOM   52   C CB  . ARG A 1 30  ? -38.05756 31.22015  -52.14149 1.000 69.69000  ? 148 ARG A CB  1 
ATOM   53   C CG  . ARG A 1 30  ? -37.87092 30.21989  -53.27305 1.000 78.40000  ? 148 ARG A CG  1 
ATOM   54   C CD  . ARG A 1 30  ? -37.31198 30.89587  -54.51955 1.000 82.67000  ? 148 ARG A CD  1 
ATOM   55   N NE  . ARG A 1 30  ? -38.26630 31.85477  -55.06716 1.000 86.72000  ? 148 ARG A NE  1 
ATOM   56   C CZ  . ARG A 1 30  ? -39.19700 31.55490  -55.96951 1.000 90.04000  ? 148 ARG A CZ  1 
ATOM   57   N NH1 . ARG A 1 30  ? -39.29237 30.31213  -56.44526 1.000 87.16000  ? 148 ARG A NH1 1 
ATOM   58   N NH2 . ARG A 1 30  ? -40.03234 32.50078  -56.39511 1.000 85.00000  ? 148 ARG A NH2 1 
ATOM   59   N N   . MET A 1 31  ? -38.88664 32.46009  -49.26092 1.000 66.08000  ? 149 MET A N   1 
ATOM   60   C CA  . MET A 1 31  ? -38.50023 33.33362  -48.16433 1.000 61.95000  ? 149 MET A CA  1 
ATOM   61   C C   . MET A 1 31  ? -38.71218 32.66074  -46.81977 1.000 55.48000  ? 149 MET A C   1 
ATOM   62   O O   . MET A 1 31  ? -37.95547 32.91651  -45.87448 1.000 65.42000  ? 149 MET A O   1 
ATOM   63   C CB  . MET A 1 31  ? -39.28079 34.65132  -48.24370 1.000 66.21000  ? 149 MET A CB  1 
ATOM   64   C CG  . MET A 1 31  ? -38.75602 35.63118  -49.31403 1.000 71.74000  ? 149 MET A CG  1 
ATOM   65   S SD  . MET A 1 31  ? -36.94499 35.63807  -49.47569 1.000 87.88000  ? 149 MET A SD  1 
ATOM   66   C CE  . MET A 1 31  ? -36.67599 36.31915  -51.11424 1.000 84.51000  ? 149 MET A CE  1 
ATOM   67   N N   . MET A 1 32  ? -39.72382 31.80124  -46.72546 1.000 52.55000  ? 150 MET A N   1 
ATOM   68   C CA  . MET A 1 32  ? -39.96271 31.04041  -45.50595 1.000 53.81000  ? 150 MET A CA  1 
ATOM   69   C C   . MET A 1 32  ? -38.77538 30.13274  -45.17526 1.000 52.88000  ? 150 MET A C   1 
ATOM   70   O O   . MET A 1 32  ? -38.40453 29.98421  -44.00328 1.000 45.51000  ? 150 MET A O   1 
ATOM   71   C CB  . MET A 1 32  ? -41.25133 30.24096  -45.69466 1.000 54.64000  ? 150 MET A CB  1 
ATOM   72   C CG  . MET A 1 32  ? -41.80325 29.55302  -44.50916 1.000 55.38000  ? 150 MET A CG  1 
ATOM   73   S SD  . MET A 1 32  ? -43.35782 28.77963  -45.00291 1.000 62.28000  ? 150 MET A SD  1 
ATOM   74   C CE  . MET A 1 32  ? -44.46337 30.15930  -45.26730 1.000 64.95000  ? 150 MET A CE  1 
ATOM   75   N N   . ILE A 1 33  ? -38.20690 29.46958  -46.18755 1.000 44.20000  ? 151 ILE A N   1 
ATOM   76   C CA  . ILE A 1 33  ? -36.99859 28.67899  -45.98279 1.000 47.64000  ? 151 ILE A CA  1 
ATOM   77   C C   . ILE A 1 33  ? -35.81605 29.57930  -45.61804 1.000 50.69000  ? 151 ILE A C   1 
ATOM   78   O O   . ILE A 1 33  ? -35.00807 29.24314  -44.74509 1.000 53.22000  ? 151 ILE A O   1 
ATOM   79   C CB  . ILE A 1 33  ? -36.69599 27.83186  -47.23323 1.000 49.66000  ? 151 ILE A CB  1 
ATOM   80   C CG1 . ILE A 1 33  ? -37.80849 26.81152  -47.48804 1.000 41.49000  ? 151 ILE A CG1 1 
ATOM   81   C CG2 . ILE A 1 33  ? -35.32470 27.11639  -47.10440 1.000 44.59000  ? 151 ILE A CG2 1 
ATOM   82   C CD1 . ILE A 1 33  ? -37.76499 26.25136  -48.89036 1.000 36.98000  ? 151 ILE A CD1 1 
ATOM   83   N N   . ARG A 1 34  ? -35.67242 30.71077  -46.31335 1.000 50.07000  ? 152 ARG A N   1 
ATOM   84   C CA  . ARG A 1 34  ? -34.59488 31.65608  -46.03160 1.000 47.01000  ? 152 ARG A CA  1 
ATOM   85   C C   . ARG A 1 34  ? -34.57532 32.02122  -44.55938 1.000 46.82000  ? 152 ARG A C   1 
ATOM   86   O O   . ARG A 1 34  ? -33.50847 32.11032  -43.93913 1.000 48.51000  ? 152 ARG A O   1 
ATOM   87   C CB  . ARG A 1 34  ? -34.77629 32.92750  -46.88088 1.000 54.15000  ? 152 ARG A CB  1 
ATOM   88   C CG  . ARG A 1 34  ? -33.62028 33.31054  -47.79945 1.000 50.76000  ? 152 ARG A CG  1 
ATOM   89   N N   . GLU A 1 35  ? -35.75152 32.23436  -43.97947 1.000 41.94000  ? 153 GLU A N   1 
ATOM   90   C CA  . GLU A 1 35  ? -35.81395 32.62251  -42.57925 1.000 43.76000  ? 153 GLU A CA  1 
ATOM   91   C C   . GLU A 1 35  ? -35.42861 31.46514  -41.66286 1.000 47.10000  ? 153 GLU A C   1 
ATOM   92   O O   . GLU A 1 35  ? -34.70788 31.65788  -40.67762 1.000 48.94000  ? 153 GLU A O   1 
ATOM   93   C CB  . GLU A 1 35  ? -37.21723 33.12671  -42.24922 1.000 39.06000  ? 153 GLU A CB  1 
ATOM   94   C CG  . GLU A 1 35  ? -37.29574 33.70986  -40.87289 1.000 48.09000  ? 153 GLU A CG  1 
ATOM   95   C CD  . GLU A 1 35  ? -38.57511 34.44817  -40.64069 1.000 51.95000  ? 153 GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 35  ? -39.49587 34.26025  -41.46397 1.000 60.11000  ? 153 GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 35  ? -38.63064 35.25457  -39.67523 1.000 52.33000  ? 153 GLU A OE2 1 
ATOM   98   N N   . LEU A 1 36  ? -35.91803 30.26011  -41.96366 1.000 42.59000  ? 154 LEU A N   1 
ATOM   99   C CA  . LEU A 1 36  ? -35.57266 29.09179  -41.16728 1.000 38.37000  ? 154 LEU A CA  1 
ATOM   100  C C   . LEU A 1 36  ? -34.07553 28.82748  -41.22316 1.000 39.83000  ? 154 LEU A C   1 
ATOM   101  O O   . LEU A 1 36  ? -33.41666 28.67916  -40.18513 1.000 39.04000  ? 154 LEU A O   1 
ATOM   102  C CB  . LEU A 1 36  ? -36.35604 27.87774  -41.67514 1.000 36.70000  ? 154 LEU A CB  1 
ATOM   103  C CG  . LEU A 1 36  ? -37.86012 27.96894  -41.42437 1.000 34.55000  ? 154 LEU A CG  1 
ATOM   104  C CD1 . LEU A 1 36  ? -38.54449 26.76197  -41.99120 1.000 33.94000  ? 154 LEU A CD1 1 
ATOM   105  C CD2 . LEU A 1 36  ? -38.15345 28.09094  -39.94835 1.000 30.62000  ? 154 LEU A CD2 1 
ATOM   106  N N   . MET A 1 37  ? -33.52328 28.76043  -42.43710 1.000 38.07000  ? 155 MET A N   1 
ATOM   107  C CA  . MET A 1 37  ? -32.09416 28.55215  -42.59696 1.000 36.65000  ? 155 MET A CA  1 
ATOM   108  C C   . MET A 1 37  ? -31.30376 29.60005  -41.82520 1.000 43.85000  ? 155 MET A C   1 
ATOM   109  O O   . MET A 1 37  ? -30.30175 29.29010  -41.17119 1.000 47.41000  ? 155 MET A O   1 
ATOM   110  C CB  . MET A 1 37  ? -31.73391 28.61217  -44.06486 1.000 36.84000  ? 155 MET A CB  1 
ATOM   111  C CG  . MET A 1 37  ? -32.17124 27.39945  -44.85365 1.000 42.81000  ? 155 MET A CG  1 
ATOM   112  S SD  . MET A 1 37  ? -31.54475 25.94825  -44.05639 1.000 40.75000  ? 155 MET A SD  1 
ATOM   113  C CE  . MET A 1 37  ? -30.05146 25.68446  -45.00527 1.000 37.64000  ? 155 MET A CE  1 
ATOM   114  N N   . ASP A 1 38  ? -31.76030 30.84488  -41.87655 1.000 43.95000  ? 156 ASP A N   1 
ATOM   115  C CA  . ASP A 1 38  ? -31.11290 31.91073  -41.13480 1.000 37.84000  ? 156 ASP A CA  1 
ATOM   116  C C   . ASP A 1 38  ? -31.13305 31.61684  -39.64898 1.000 42.65000  ? 156 ASP A C   1 
ATOM   117  O O   . ASP A 1 38  ? -30.09921 31.70390  -38.97374 1.000 43.72000  ? 156 ASP A O   1 
ATOM   118  C CB  . ASP A 1 38  ? -31.81243 33.23059  -41.43016 1.000 47.20000  ? 156 ASP A CB  1 
ATOM   119  C CG  . ASP A 1 38  ? -30.93100 34.41981  -41.14530 1.000 57.29000  ? 156 ASP A CG  1 
ATOM   120  O OD1 . ASP A 1 38  ? -29.81091 34.46365  -41.73106 1.000 59.40000  ? 156 ASP A OD1 1 
ATOM   121  O OD2 . ASP A 1 38  ? -31.37053 35.30316  -40.36886 1.000 50.36000  ? 156 ASP A OD2 1 
ATOM   122  N N   . ALA A 1 39  ? -32.30799 31.26802  -39.11640 1.000 39.04000  ? 157 ALA A N   1 
ATOM   123  C CA  . ALA A 1 39  ? -32.39411 30.94115  -37.70061 1.000 34.72000  ? 157 ALA A CA  1 
ATOM   124  C C   . ALA A 1 39  ? -31.48666 29.76635  -37.36813 1.000 39.88000  ? 157 ALA A C   1 
ATOM   125  O O   . ALA A 1 39  ? -30.75785 29.78708  -36.36898 1.000 40.96000  ? 157 ALA A O   1 
ATOM   126  C CB  . ALA A 1 39  ? -33.83905 30.63529  -37.32606 1.000 37.43000  ? 157 ALA A CB  1 
ATOM   127  N N   . GLN A 1 40  ? -31.49905 28.73784  -38.20674 1.000 36.60000  ? 158 GLN A N   1 
ATOM   128  C CA  . GLN A 1 40  ? -30.62260 27.60908  -37.96524 1.000 35.80000  ? 158 GLN A CA  1 
ATOM   129  C C   . GLN A 1 40  ? -29.17181 28.06468  -37.90670 1.000 38.86000  ? 158 GLN A C   1 
ATOM   130  O O   . GLN A 1 40  ? -28.44183 27.70845  -36.97278 1.000 36.15000  ? 158 GLN A O   1 
ATOM   131  C CB  . GLN A 1 40  ? -30.83194 26.55563  -39.05390 1.000 40.43000  ? 158 GLN A CB  1 
ATOM   132  C CG  . GLN A 1 40  ? -30.10940 25.23481  -38.82354 1.000 34.55000  ? 158 GLN A CG  1 
ATOM   133  C CD  . GLN A 1 40  ? -30.88916 24.30193  -37.91223 1.000 35.84000  ? 158 GLN A CD  1 
ATOM   134  O OE1 . GLN A 1 40  ? -31.36054 24.69008  -36.82409 1.000 31.93000  ? 158 GLN A OE1 1 
ATOM   135  N NE2 . GLN A 1 40  ? -31.05354 23.06812  -38.36299 1.000 37.15000  ? 158 GLN A NE2 1 
ATOM   136  N N   . MET A 1 41  ? -28.74399 28.87545  -38.89215 1.000 38.73000  ? 159 MET A N   1 
ATOM   137  C CA  . MET A 1 41  ? -27.36620 29.36807  -38.92761 1.000 34.92000  ? 159 MET A CA  1 
ATOM   138  C C   . MET A 1 41  ? -27.00576 30.13449  -37.67509 1.000 33.18000  ? 159 MET A C   1 
ATOM   139  O O   . MET A 1 41  ? -25.89180 30.00568  -37.15696 1.000 38.43000  ? 159 MET A O   1 
ATOM   140  C CB  . MET A 1 41  ? -27.13437 30.26988  -40.13003 1.000 39.56000  ? 159 MET A CB  1 
ATOM   141  C CG  . MET A 1 41  ? -25.68657 30.75055  -40.18648 1.000 42.46000  ? 159 MET A CG  1 
ATOM   142  S SD  . MET A 1 41  ? -25.56743 32.46424  -39.57745 1.000 43.04000  ? 159 MET A SD  1 
ATOM   143  C CE  . MET A 1 41  ? -26.87859 33.22822  -40.52125 1.000 36.41000  ? 159 MET A CE  1 
ATOM   144  N N   . LYS A 1 42  ? -27.91721 30.95981  -37.19377 1.000 33.28000  ? 160 LYS A N   1 
ATOM   145  C CA  . LYS A 1 42  ? -27.58180 31.84032  -36.09719 1.000 31.72000  ? 160 LYS A CA  1 
ATOM   146  C C   . LYS A 1 42  ? -27.59974 31.13252  -34.75861 1.000 36.09000  ? 160 LYS A C   1 
ATOM   147  O O   . LYS A 1 42  ? -26.99314 31.63623  -33.81120 1.000 41.89000  ? 160 LYS A O   1 
ATOM   148  C CB  . LYS A 1 42  ? -28.54733 33.03087  -36.05967 1.000 35.42000  ? 160 LYS A CB  1 
ATOM   149  C CG  . LYS A 1 42  ? -28.31960 34.09961  -37.14000 1.000 35.23000  ? 160 LYS A CG  1 
ATOM   150  C CD  . LYS A 1 42  ? -29.59492 34.93820  -37.39474 1.000 43.19000  ? 160 LYS A CD  1 
ATOM   151  C CE  . LYS A 1 42  ? -29.30032 36.19981  -38.21795 1.000 46.10000  ? 160 LYS A CE  1 
ATOM   152  N N   . THR A 1 43  ? -28.29127 30.01016  -34.65440 1.000 35.25000  ? 161 THR A N   1 
ATOM   153  C CA  . THR A 1 43  ? -28.50126 29.42028  -33.31278 1.000 36.05000  ? 161 THR A CA  1 
ATOM   154  C C   . THR A 1 43  ? -27.99665 27.98742  -33.18153 1.000 37.63000  ? 161 THR A C   1 
ATOM   155  O O   . THR A 1 43  ? -28.13760 27.42073  -32.11389 1.000 29.62000  ? 161 THR A O   1 
ATOM   156  C CB  . THR A 1 43  ? -29.98835 29.49843  -32.98801 1.000 36.21000  ? 161 THR A CB  1 
ATOM   157  O OG1 . THR A 1 43  ? -30.65591 28.96981  -34.12045 1.000 40.21000  ? 161 THR A OG1 1 
ATOM   158  C CG2 . THR A 1 43  ? -30.45800 30.91713  -32.82627 1.000 35.96000  ? 161 THR A CG2 1 
ATOM   159  N N   . PHE A 1 44  ? -27.41522 27.43629  -34.22575 1.000 31.03000  ? 162 PHE A N   1 
ATOM   160  C CA  . PHE A 1 44  ? -26.96262 26.03542  -34.12149 1.000 32.74000  ? 162 PHE A CA  1 
ATOM   161  C C   . PHE A 1 44  ? -25.44561 26.01412  -34.16622 1.000 36.12000  ? 162 PHE A C   1 
ATOM   162  O O   . PHE A 1 44  ? -24.89259 26.39995  -35.16789 1.000 42.67000  ? 162 PHE A O   1 
ATOM   163  C CB  . PHE A 1 44  ? -27.60806 25.21179  -35.22909 1.000 29.54000  ? 162 PHE A CB  1 
ATOM   164  C CG  . PHE A 1 44  ? -27.36243 23.73684  -35.13591 1.000 33.66000  ? 162 PHE A CG  1 
ATOM   165  C CD1 . PHE A 1 44  ? -26.76040 23.19246  -34.02412 1.000 34.10000  ? 162 PHE A CD1 1 
ATOM   166  C CD2 . PHE A 1 44  ? -27.72787 22.89929  -36.16147 1.000 29.64000  ? 162 PHE A CD2 1 
ATOM   167  C CE1 . PHE A 1 44  ? -26.51382 21.83752  -33.94987 1.000 36.33000  ? 162 PHE A CE1 1 
ATOM   168  C CE2 . PHE A 1 44  ? -27.49629 21.54434  -36.07922 1.000 30.34000  ? 162 PHE A CE2 1 
ATOM   169  C CZ  . PHE A 1 44  ? -26.88427 21.02096  -34.97942 1.000 33.32000  ? 162 PHE A CZ  1 
ATOM   170  N N   . ASP A 1 45  ? -24.83064 25.61874  -33.06134 1.000 38.45000  ? 163 ASP A N   1 
ATOM   171  C CA  . ASP A 1 45  ? -23.36362 25.51729  -32.91713 1.000 36.40000  ? 163 ASP A CA  1 
ATOM   172  C C   . ASP A 1 45  ? -22.95893 24.10470  -33.31388 1.000 41.09000  ? 163 ASP A C   1 
ATOM   173  O O   . ASP A 1 45  ? -22.83972 23.26926  -32.46235 1.000 42.31000  ? 163 ASP A O   1 
ATOM   174  C CB  . ASP A 1 45  ? -22.99602 25.82861  -31.47788 1.000 41.55000  ? 163 ASP A CB  1 
ATOM   175  C CG  . ASP A 1 45  ? -21.52014 25.99412  -31.23751 1.000 48.59000  ? 163 ASP A CG  1 
ATOM   176  O OD1 . ASP A 1 45  ? -20.79204 26.17599  -32.18826 1.000 51.90000  ? 163 ASP A OD1 1 
ATOM   177  O OD2 . ASP A 1 45  ? -21.14333 25.94762  -30.10346 1.000 50.97000  ? 163 ASP A OD2 1 
ATOM   178  N N   . THR A 1 46  ? -22.74060 23.89755  -34.59596 1.000 42.23000  ? 164 THR A N   1 
ATOM   179  C CA  . THR A 1 46  ? -22.43791 22.57603  -35.17368 1.000 35.89000  ? 164 THR A CA  1 
ATOM   180  C C   . THR A 1 46  ? -21.09277 22.05133  -34.68474 1.000 42.87000  ? 164 THR A C   1 
ATOM   181  O O   . THR A 1 46  ? -20.90024 20.85345  -34.74841 1.000 46.83000  ? 164 THR A O   1 
ATOM   182  C CB  . THR A 1 46  ? -22.60868 22.67184  -36.68466 1.000 40.68000  ? 164 THR A CB  1 
ATOM   183  O OG1 . THR A 1 46  ? -21.81909 23.78841  -37.06286 1.000 47.32000  ? 164 THR A OG1 1 
ATOM   184  C CG2 . THR A 1 46  ? -24.03175 22.98943  -37.05974 1.000 37.25000  ? 164 THR A CG2 1 
ATOM   185  N N   . THR A 1 47  ? -20.19724 22.92146  -34.24207 1.000 41.14000  ? 165 THR A N   1 
ATOM   186  C CA  . THR A 1 47  ? -18.90614 22.48172  -33.71309 1.000 43.54000  ? 165 THR A CA  1 
ATOM   187  C C   . THR A 1 47  ? -18.86741 22.45984  -32.19909 1.000 44.57000  ? 165 THR A C   1 
ATOM   188  O O   . THR A 1 47  ? -17.83236 22.10696  -31.62811 1.000 50.40000  ? 165 THR A O   1 
ATOM   189  C CB  . THR A 1 47  ? -17.76645 23.39150  -34.19034 1.000 44.63000  ? 165 THR A CB  1 
ATOM   190  O OG1 . THR A 1 47  ? -18.12609 24.75920  -33.96260 1.000 49.30000  ? 165 THR A OG1 1 
ATOM   191  C CG2 . THR A 1 47  ? -17.49909 23.18348  -35.65942 1.000 47.92000  ? 165 THR A CG2 1 
ATOM   192  N N   . PHE A 1 48  ? -19.93972 22.88698  -31.53804 1.000 41.88000  ? 166 PHE A N   1 
ATOM   193  C CA  . PHE A 1 48  ? -20.03699 22.88409  -30.08106 1.000 46.64000  ? 166 PHE A CA  1 
ATOM   194  C C   . PHE A 1 48  ? -18.91746 23.69520  -29.43738 1.000 51.81000  ? 166 PHE A C   1 
ATOM   195  O O   . PHE A 1 48  ? -18.62861 23.53363  -28.24642 1.000 57.44000  ? 166 PHE A O   1 
ATOM   196  C CB  . PHE A 1 48  ? -20.07946 21.44575  -29.53491 1.000 35.40000  ? 166 PHE A CB  1 
ATOM   197  C CG  . PHE A 1 48  ? -21.33106 20.70443  -29.93458 1.000 39.09000  ? 166 PHE A CG  1 
ATOM   198  C CD1 . PHE A 1 48  ? -21.51864 20.28913  -31.25686 1.000 32.66000  ? 166 PHE A CD1 1 
ATOM   199  C CD2 . PHE A 1 48  ? -22.33112 20.43645  -29.00392 1.000 38.46000  ? 166 PHE A CD2 1 
ATOM   200  C CE1 . PHE A 1 48  ? -22.69027 19.62884  -31.64146 1.000 33.84000  ? 166 PHE A CE1 1 
ATOM   201  C CE2 . PHE A 1 48  ? -23.49675 19.76315  -29.37653 1.000 36.44000  ? 166 PHE A CE2 1 
ATOM   202  C CZ  . PHE A 1 48  ? -23.67433 19.35085  -30.69781 1.000 30.25000  ? 166 PHE A CZ  1 
ATOM   203  N N   . SER A 1 49  ? -18.31571 24.59292  -30.22174 1.000 49.84000  ? 167 SER A N   1 
ATOM   204  C CA  . SER A 1 49  ? -17.30121 25.51908  -29.73201 1.000 47.63000  ? 167 SER A CA  1 
ATOM   205  C C   . SER A 1 49  ? -17.70276 26.21814  -28.43167 1.000 51.20000  ? 167 SER A C   1 
ATOM   206  O O   . SER A 1 49  ? -16.84005 26.53303  -27.60132 1.000 55.01000  ? 167 SER A O   1 
ATOM   207  C CB  . SER A 1 49  ? -17.03847 26.56683  -30.81634 1.000 58.28000  ? 167 SER A CB  1 
ATOM   208  O OG  . SER A 1 49  ? -16.68997 25.95571  -32.04664 1.000 63.35000  ? 167 SER A OG  1 
ATOM   209  N N   . HIS A 1 50  ? -18.99091 26.48846  -28.23475 1.000 49.15000  ? 168 HIS A N   1 
ATOM   210  C CA  . HIS A 1 50  ? -19.42549 27.35063  -27.14232 1.000 44.67000  ? 168 HIS A CA  1 
ATOM   211  C C   . HIS A 1 50  ? -20.08236 26.58168  -26.01489 1.000 49.09000  ? 168 HIS A C   1 
ATOM   212  O O   . HIS A 1 50  ? -20.67880 27.19690  -25.12664 1.000 48.68000  ? 168 HIS A O   1 
ATOM   213  C CB  . HIS A 1 50  ? -20.36487 28.43752  -27.66486 1.000 48.89000  ? 168 HIS A CB  1 
ATOM   214  C CG  . HIS A 1 50  ? -19.72507 29.31741  -28.69722 1.000 63.69000  ? 168 HIS A CG  1 
ATOM   215  N ND1 . HIS A 1 50  ? -18.82956 30.31461  -28.37147 1.000 57.05000  ? 168 HIS A ND1 1 
ATOM   216  C CD2 . HIS A 1 50  ? -19.80381 29.31017  -30.05124 1.000 64.02000  ? 168 HIS A CD2 1 
ATOM   217  C CE1 . HIS A 1 50  ? -18.40461 30.89845  -29.47905 1.000 64.25000  ? 168 HIS A CE1 1 
ATOM   218  N NE2 . HIS A 1 50  ? -18.98116 30.31080  -30.51150 1.000 68.12000  ? 168 HIS A NE2 1 
ATOM   219  N N   . PHE A 1 51  ? -19.97978 25.25473  -26.02665 1.000 45.55000  ? 169 PHE A N   1 
ATOM   220  C CA  . PHE A 1 51  ? -20.46261 24.41188  -24.93924 1.000 40.98000  ? 169 PHE A CA  1 
ATOM   221  C C   . PHE A 1 51  ? -19.31070 24.19581  -23.96315 1.000 49.86000  ? 169 PHE A C   1 
ATOM   222  O O   . PHE A 1 51  ? -18.45928 23.32530  -24.16451 1.000 50.84000  ? 169 PHE A O   1 
ATOM   223  C CB  . PHE A 1 51  ? -20.99493 23.09797  -25.49911 1.000 41.03000  ? 169 PHE A CB  1 
ATOM   224  C CG  . PHE A 1 51  ? -21.43669 22.11017  -24.45577 1.000 39.46000  ? 169 PHE A CG  1 
ATOM   225  C CD1 . PHE A 1 51  ? -22.32004 22.48519  -23.44171 1.000 36.57000  ? 169 PHE A CD1 1 
ATOM   226  C CD2 . PHE A 1 51  ? -20.98610 20.78939  -24.50446 1.000 33.77000  ? 169 PHE A CD2 1 
ATOM   227  C CE1 . PHE A 1 51  ? -22.74082 21.57444  -22.48733 1.000 31.53000  ? 169 PHE A CE1 1 
ATOM   228  C CE2 . PHE A 1 51  ? -21.40188 19.87765  -23.55108 1.000 36.41000  ? 169 PHE A CE2 1 
ATOM   229  C CZ  . PHE A 1 51  ? -22.28724 20.27167  -22.54001 1.000 32.84000  ? 169 PHE A CZ  1 
ATOM   230  N N   . LYS A 1 52  ? -19.27724 24.99320  -22.90568 1.000 50.43000  ? 170 LYS A N   1 
ATOM   231  C CA  . LYS A 1 52  ? -18.23140 24.92007  -21.89753 1.000 55.02000  ? 170 LYS A CA  1 
ATOM   232  C C   . LYS A 1 52  ? -18.85954 24.67499  -20.51979 1.000 59.36000  ? 170 LYS A C   1 
ATOM   233  O O   . LYS A 1 52  ? -20.07950 24.52637  -20.38310 1.000 62.00000  ? 170 LYS A O   1 
ATOM   234  C CB  . LYS A 1 52  ? -17.39195 26.20146  -21.92962 1.000 61.13000  ? 170 LYS A CB  1 
ATOM   235  C CG  . LYS A 1 52  ? -16.56579 26.36557  -23.21037 1.000 60.50000  ? 170 LYS A CG  1 
ATOM   236  N N   . ASN A 1 53  ? -18.01071 24.62576  -19.49566 1.000 57.43000  ? 171 ASN A N   1 
ATOM   237  C CA  . ASN A 1 53  ? -18.42992 24.50075  -18.09281 1.000 60.28000  ? 171 ASN A CA  1 
ATOM   238  C C   . ASN A 1 53  ? -19.52349 23.45117  -17.92463 1.000 63.07000  ? 171 ASN A C   1 
ATOM   239  O O   . ASN A 1 53  ? -20.65669 23.74845  -17.54666 1.000 77.89000  ? 171 ASN A O   1 
ATOM   240  C CB  . ASN A 1 53  ? -18.90961 25.83620  -17.50911 1.000 67.08000  ? 171 ASN A CB  1 
ATOM   241  C CG  . ASN A 1 53  ? -17.98706 27.01079  -17.83825 1.000 76.12000  ? 171 ASN A CG  1 
ATOM   242  O OD1 . ASN A 1 53  ? -16.76197 26.85742  -17.98612 1.000 67.10000  ? 171 ASN A OD1 1 
ATOM   243  N ND2 . ASN A 1 53  ? -18.57857 28.20758  -17.91966 1.000 73.03000  ? 171 ASN A ND2 1 
ATOM   244  N N   . PHE A 1 54  ? -19.17689 22.20750  -18.22530 1.000 53.75000  ? 172 PHE A N   1 
ATOM   245  C CA  . PHE A 1 54  ? -20.12143 21.11401  -18.09411 1.000 49.96000  ? 172 PHE A CA  1 
ATOM   246  C C   . PHE A 1 54  ? -19.55216 20.08369  -17.13361 1.000 48.46000  ? 172 PHE A C   1 
ATOM   247  O O   . PHE A 1 54  ? -18.33513 19.96314  -16.98746 1.000 56.90000  ? 172 PHE A O   1 
ATOM   248  C CB  . PHE A 1 54  ? -20.44390 20.47367  -19.46155 1.000 48.79000  ? 172 PHE A CB  1 
ATOM   249  C CG  . PHE A 1 54  ? -19.22658 20.09968  -20.27054 1.000 49.32000  ? 172 PHE A CG  1 
ATOM   250  C CD1 . PHE A 1 54  ? -18.47515 18.97082  -19.95607 1.000 46.29000  ? 172 PHE A CD1 1 
ATOM   251  C CD2 . PHE A 1 54  ? -18.84172 20.86649  -21.36302 1.000 46.31000  ? 172 PHE A CD2 1 
ATOM   252  C CE1 . PHE A 1 54  ? -17.35286 18.63176  -20.71106 1.000 48.56000  ? 172 PHE A CE1 1 
ATOM   253  C CE2 . PHE A 1 54  ? -17.72243 20.52543  -22.12602 1.000 42.04000  ? 172 PHE A CE2 1 
ATOM   254  C CZ  . PHE A 1 54  ? -16.96900 19.42156  -21.79652 1.000 38.12000  ? 172 PHE A CZ  1 
ATOM   255  N N   . ARG A 1 55  ? -20.45496 19.35291  -16.47221 1.000 44.07000  ? 173 ARG A N   1 
ATOM   256  C CA  . ARG A 1 55  ? -20.07070 18.34048  -15.45373 1.000 43.84000  ? 173 ARG A CA  1 
ATOM   257  C C   . ARG A 1 55  ? -19.73199 16.99801  -16.11346 1.000 43.43000  ? 173 ARG A C   1 
ATOM   258  O O   . ARG A 1 55  ? -20.36965 16.64533  -17.12578 1.000 44.36000  ? 173 ARG A O   1 
ATOM   259  C CB  . ARG A 1 55  ? -21.19182 18.17138  -14.42404 1.000 40.07000  ? 173 ARG A CB  1 
ATOM   260  C CG  . ARG A 1 55  ? -21.48752 19.42678  -13.61435 1.000 45.94000  ? 173 ARG A CG  1 
ATOM   261  C CD  . ARG A 1 55  ? -22.76662 19.30674  -12.80866 1.000 37.59000  ? 173 ARG A CD  1 
ATOM   262  N NE  . ARG A 1 55  ? -23.95753 19.45471  -13.63279 1.000 44.45000  ? 173 ARG A NE  1 
ATOM   263  C CZ  . ARG A 1 55  ? -25.18044 19.09795  -13.25923 1.000 48.20000  ? 173 ARG A CZ  1 
ATOM   264  N NH1 . ARG A 1 55  ? -25.38043 18.56816  -12.06458 1.000 55.32000  ? 173 ARG A NH1 1 
ATOM   265  N NH2 . ARG A 1 55  ? -26.20037 19.27298  -14.08032 1.000 41.44000  ? 173 ARG A NH2 1 
ATOM   266  N N   . LEU A 1 56  ? -18.75379 16.29710  -15.53369 1.000 45.78000  ? 174 LEU A N   1 
ATOM   267  C CA  . LEU A 1 56  ? -18.30014 14.98455  -15.96638 1.000 48.87000  ? 174 LEU A CA  1 
ATOM   268  C C   . LEU A 1 56  ? -18.40293 14.01883  -14.80196 1.000 48.02000  ? 174 LEU A C   1 
ATOM   269  O O   . LEU A 1 56  ? -18.50633 14.43410  -13.64074 1.000 43.02000  ? 174 LEU A O   1 
ATOM   270  C CB  . LEU A 1 56  ? -16.85407 15.03749  -16.48508 1.000 44.61000  ? 174 LEU A CB  1 
ATOM   271  C CG  . LEU A 1 56  ? -16.74807 15.65137  -17.89570 1.000 53.17000  ? 174 LEU A CG  1 
ATOM   272  C CD1 . LEU A 1 56  ? -15.30713 15.96425  -18.32825 1.000 45.02000  ? 174 LEU A CD1 1 
ATOM   273  C CD2 . LEU A 1 56  ? -17.48551 14.80967  -18.95233 1.000 43.83000  ? 174 LEU A CD2 1 
ATOM   274  N N   . PRO A 1 57  ? -18.39731 12.71998  -15.06772 1.000 48.89000  ? 175 PRO A N   1 
ATOM   275  C CA  . PRO A 1 57  ? -18.33910 11.76136  -13.95928 1.000 49.82000  ? 175 PRO A CA  1 
ATOM   276  C C   . PRO A 1 57  ? -17.02529 11.88648  -13.19496 1.000 63.89000  ? 175 PRO A C   1 
ATOM   277  O O   . PRO A 1 57  ? -16.01240 12.35324  -13.72650 1.000 59.99000  ? 175 PRO A O   1 
ATOM   278  C CB  . PRO A 1 57  ? -18.46738 10.41171  -14.65409 1.000 45.91000  ? 175 PRO A CB  1 
ATOM   279  C CG  . PRO A 1 57  ? -19.15228 10.73218  -15.96003 1.000 46.53000  ? 175 PRO A CG  1 
ATOM   280  C CD  . PRO A 1 57  ? -18.59278 12.05766  -16.36615 1.000 42.75000  ? 175 PRO A CD  1 
ATOM   281  N N   . GLY A 1 58  ? -17.05736 11.48972  -11.92220 1.000 65.46000  ? 176 GLY A N   1 
ATOM   282  C CA  . GLY A 1 58  ? -15.91160 11.67071  -11.04488 1.000 66.62000  ? 176 GLY A CA  1 
ATOM   283  C C   . GLY A 1 58  ? -14.83611 10.60626  -11.17231 1.000 65.73000  ? 176 GLY A C   1 
ATOM   284  O O   . GLY A 1 58  ? -13.65227 10.88965  -10.95892 1.000 67.96000  ? 176 GLY A O   1 
ATOM   285  N N   . SER A 1 74  ? -38.29229 -0.57764  0.07779   1.000 83.50000  ? 192 SER A N   1 
ATOM   286  C CA  . SER A 1 74  ? -39.67609 -1.05328  0.13926   1.000 87.26000  ? 192 SER A CA  1 
ATOM   287  C C   . SER A 1 74  ? -40.15165 -1.48568  -1.24009  1.000 89.72000  ? 192 SER A C   1 
ATOM   288  O O   . SER A 1 74  ? -39.46356 -1.25579  -2.23282  1.000 91.09000  ? 192 SER A O   1 
ATOM   289  C CB  . SER A 1 74  ? -40.60367 0.02698   0.71372   1.000 84.36000  ? 192 SER A CB  1 
ATOM   290  O OG  . SER A 1 74  ? -40.70401 1.15643   -0.13664  1.000 81.26000  ? 192 SER A OG  1 
ATOM   291  N N   . ARG A 1 75  ? -41.32936 -2.11316  -1.30267  1.000 94.87000  ? 193 ARG A N   1 
ATOM   292  C CA  . ARG A 1 75  ? -41.77987 -2.68961  -2.56809  1.000 93.46000  ? 193 ARG A CA  1 
ATOM   293  C C   . ARG A 1 75  ? -42.20217 -1.60522  -3.55554  1.000 87.04000  ? 193 ARG A C   1 
ATOM   294  O O   . ARG A 1 75  ? -41.96689 -1.73640  -4.76257  1.000 87.04000  ? 193 ARG A O   1 
ATOM   295  C CB  . ARG A 1 75  ? -42.91648 -3.68725  -2.32489  1.000 77.36000  ? 193 ARG A CB  1 
ATOM   296  N N   . GLU A 1 76  ? -42.81573 -0.52277  -3.06801  1.000 87.04000  ? 194 GLU A N   1 
ATOM   297  C CA  . GLU A 1 76  ? -43.20104 0.56859   -3.96544  1.000 96.50000  ? 194 GLU A CA  1 
ATOM   298  C C   . GLU A 1 76  ? -41.97220 1.19751   -4.61985  1.000 92.32000  ? 194 GLU A C   1 
ATOM   299  O O   . GLU A 1 76  ? -41.95909 1.45223   -5.83169  1.000 81.15000  ? 194 GLU A O   1 
ATOM   300  C CB  . GLU A 1 76  ? -44.01565 1.62979   -3.20897  1.000 74.30000  ? 194 GLU A CB  1 
ATOM   301  N N   . GLU A 1 77  ? -40.92245 1.43950   -3.82551  1.000 87.25000  ? 195 GLU A N   1 
ATOM   302  C CA  . GLU A 1 77  ? -39.70862 2.05534   -4.34592  1.000 76.39000  ? 195 GLU A CA  1 
ATOM   303  C C   . GLU A 1 77  ? -38.87005 1.08419   -5.15834  1.000 82.56000  ? 195 GLU A C   1 
ATOM   304  O O   . GLU A 1 77  ? -38.09708 1.51903   -6.01794  1.000 86.42000  ? 195 GLU A O   1 
ATOM   305  C CB  . GLU A 1 77  ? -38.87008 2.62404   -3.20743  1.000 85.47000  ? 195 GLU A CB  1 
ATOM   306  C CG  . GLU A 1 77  ? -39.43575 3.87242   -2.58081  1.000 88.88000  ? 195 GLU A CG  1 
ATOM   307  C CD  . GLU A 1 77  ? -39.11314 5.11405   -3.39602  1.000 86.23000  ? 195 GLU A CD  1 
ATOM   308  O OE1 . GLU A 1 77  ? -37.91428 5.47162   -3.47959  1.000 90.06000  ? 195 GLU A OE1 1 
ATOM   309  O OE2 . GLU A 1 77  ? -40.05732 5.73795   -3.93082  1.000 78.40000  ? 195 GLU A OE2 1 
ATOM   310  N N   . ALA A 1 78  ? -38.97453 -0.22002  -4.89313  1.000 88.82000  ? 196 ALA A N   1 
ATOM   311  C CA  . ALA A 1 78  ? -38.20596 -1.18222  -5.67855  1.000 89.22000  ? 196 ALA A CA  1 
ATOM   312  C C   . ALA A 1 78  ? -38.71067 -1.23760  -7.11367  1.000 85.17000  ? 196 ALA A C   1 
ATOM   313  O O   . ALA A 1 78  ? -37.91744 -1.36070  -8.05360  1.000 80.29000  ? 196 ALA A O   1 
ATOM   314  C CB  . ALA A 1 78  ? -38.26347 -2.56762  -5.03237  1.000 86.79000  ? 196 ALA A CB  1 
ATOM   315  N N   . ALA A 1 79  ? -40.02968 -1.13907  -7.29786  1.000 83.62000  ? 197 ALA A N   1 
ATOM   316  C CA  . ALA A 1 79  ? -40.59543 -1.14552  -8.64197  1.000 82.97000  ? 197 ALA A CA  1 
ATOM   317  C C   . ALA A 1 79  ? -40.23985 0.13407   -9.39015  1.000 81.36000  ? 197 ALA A C   1 
ATOM   318  O O   . ALA A 1 79  ? -40.03961 0.10888   -10.61113 1.000 78.96000  ? 197 ALA A O   1 
ATOM   319  C CB  . ALA A 1 79  ? -42.10936 -1.33523  -8.57236  1.000 69.66000  ? 197 ALA A CB  1 
ATOM   320  N N   . LYS A 1 80  ? -40.15248 1.25668   -8.66548  1.000 74.97000  ? 198 LYS A N   1 
ATOM   321  C CA  . LYS A 1 80  ? -39.68892 2.51623   -9.24665  1.000 73.51000  ? 198 LYS A CA  1 
ATOM   322  C C   . LYS A 1 80  ? -38.26177 2.39717   -9.78146  1.000 72.82000  ? 198 LYS A C   1 
ATOM   323  O O   . LYS A 1 80  ? -37.98971 2.75796   -10.93420 1.000 67.90000  ? 198 LYS A O   1 
ATOM   324  C CB  . LYS A 1 80  ? -39.77460 3.62858   -8.20301  1.000 68.02000  ? 198 LYS A CB  1 
ATOM   325  C CG  . LYS A 1 80  ? -41.11292 4.32594   -8.11985  1.000 56.75000  ? 198 LYS A CG  1 
ATOM   326  C CD  . LYS A 1 80  ? -40.93863 5.62959   -7.39105  1.000 64.21000  ? 198 LYS A CD  1 
ATOM   327  C CE  . LYS A 1 80  ? -42.12194 5.97356   -6.50907  1.000 73.46000  ? 198 LYS A CE  1 
ATOM   328  N NZ  . LYS A 1 80  ? -41.92765 7.30324   -5.83125  1.000 75.14000  ? 198 LYS A NZ  1 
ATOM   329  N N   . TRP A 1 81  ? -37.33471 1.90808   -8.94657  1.000 73.67000  ? 199 TRP A N   1 
ATOM   330  C CA  . TRP A 1 81  ? -35.95453 1.68694   -9.37645  1.000 70.06000  ? 199 TRP A CA  1 
ATOM   331  C C   . TRP A 1 81  ? -35.87587 0.66264   -10.50604 1.000 67.79000  ? 199 TRP A C   1 
ATOM   332  O O   . TRP A 1 81  ? -35.07277 0.81454   -11.43180 1.000 69.14000  ? 199 TRP A O   1 
ATOM   333  C CB  . TRP A 1 81  ? -35.09955 1.22962   -8.18856  1.000 72.06000  ? 199 TRP A CB  1 
ATOM   334  C CG  . TRP A 1 81  ? -34.44118 2.34346   -7.41878  1.000 71.07000  ? 199 TRP A CG  1 
ATOM   335  C CD1 . TRP A 1 81  ? -34.99769 3.08462   -6.41045  1.000 78.21000  ? 199 TRP A CD1 1 
ATOM   336  C CD2 . TRP A 1 81  ? -33.10136 2.82613   -7.57325  1.000 71.58000  ? 199 TRP A CD2 1 
ATOM   337  N NE1 . TRP A 1 81  ? -34.09318 4.00674   -5.94074  1.000 73.04000  ? 199 TRP A NE1 1 
ATOM   338  C CE2 . TRP A 1 81  ? -32.91999 3.86766   -6.63561  1.000 76.93000  ? 199 TRP A CE2 1 
ATOM   339  C CE3 . TRP A 1 81  ? -32.03706 2.48509   -8.41626  1.000 74.94000  ? 199 TRP A CE3 1 
ATOM   340  C CZ2 . TRP A 1 81  ? -31.71633 4.57412   -6.52097  1.000 81.82000  ? 199 TRP A CZ2 1 
ATOM   341  C CZ3 . TRP A 1 81  ? -30.83839 3.18255   -8.29762  1.000 73.96000  ? 199 TRP A CZ3 1 
ATOM   342  C CH2 . TRP A 1 81  ? -30.68901 4.21606   -7.35499  1.000 78.44000  ? 199 TRP A CH2 1 
ATOM   343  N N   . SER A 1 82  ? -36.69042 -0.39476  -10.44181 1.000 70.46000  ? 200 SER A N   1 
ATOM   344  C CA  . SER A 1 82  ? -36.65878 -1.43014  -11.47241 1.000 67.66000  ? 200 SER A CA  1 
ATOM   345  C C   . SER A 1 82  ? -37.10277 -0.88154  -12.82717 1.000 67.18000  ? 200 SER A C   1 
ATOM   346  O O   . SER A 1 82  ? -36.60139 -1.30670  -13.87733 1.000 55.61000  ? 200 SER A O   1 
ATOM   347  C CB  . SER A 1 82  ? -37.53535 -2.60678  -11.02926 1.000 69.75000  ? 200 SER A CB  1 
ATOM   348  O OG  . SER A 1 82  ? -37.55671 -3.65023  -11.98688 1.000 83.95000  ? 200 SER A OG  1 
ATOM   349  N N   . GLN A 1 83  ? -38.02719 0.07906   -12.82678 1.000 71.46000  ? 201 GLN A N   1 
ATOM   350  C CA  . GLN A 1 83  ? -38.45023 0.70661   -14.07149 1.000 66.45000  ? 201 GLN A CA  1 
ATOM   351  C C   . GLN A 1 83  ? -37.43259 1.72335   -14.58470 1.000 63.98000  ? 201 GLN A C   1 
ATOM   352  O O   . GLN A 1 83  ? -37.30243 1.89412   -15.80158 1.000 64.79000  ? 201 GLN A O   1 
ATOM   353  C CB  . GLN A 1 83  ? -39.81656 1.36089   -13.87035 1.000 62.74000  ? 201 GLN A CB  1 
ATOM   354  C CG  . GLN A 1 83  ? -40.47158 1.93534   -15.12214 1.000 59.98000  ? 201 GLN A CG  1 
ATOM   355  C CD  . GLN A 1 83  ? -40.41095 1.00305   -16.29767 1.000 60.61000  ? 201 GLN A CD  1 
ATOM   356  O OE1 . GLN A 1 83  ? -39.64988 1.22394   -17.23640 1.000 64.86000  ? 201 GLN A OE1 1 
ATOM   357  N NE2 . GLN A 1 83  ? -41.20149 -0.06432  -16.24945 1.000 71.10000  ? 201 GLN A NE2 1 
ATOM   358  N N   . VAL A 1 84  ? -36.70505 2.40415   -13.69317 1.000 58.65000  ? 202 VAL A N   1 
ATOM   359  C CA  . VAL A 1 84  ? -35.65136 3.31088   -14.14744 1.000 64.81000  ? 202 VAL A CA  1 
ATOM   360  C C   . VAL A 1 84  ? -34.50790 2.53877   -14.81168 1.000 64.68000  ? 202 VAL A C   1 
ATOM   361  O O   . VAL A 1 84  ? -33.94192 2.99960   -15.81031 1.000 57.48000  ? 202 VAL A O   1 
ATOM   362  C CB  . VAL A 1 84  ? -35.16197 4.20341   -12.98882 1.000 60.98000  ? 202 VAL A CB  1 
ATOM   363  C CG1 . VAL A 1 84  ? -33.87720 4.88919   -13.35718 1.000 59.68000  ? 202 VAL A CG1 1 
ATOM   364  C CG2 . VAL A 1 84  ? -36.20450 5.29278   -12.68338 1.000 52.52000  ? 202 VAL A CG2 1 
ATOM   365  N N   . ARG A 1 85  ? -34.16647 1.34762   -14.30032 1.000 68.93000  ? 203 ARG A N   1 
ATOM   366  C CA  . ARG A 1 85  ? -33.14899 0.52945   -14.96661 1.000 68.65000  ? 203 ARG A CA  1 
ATOM   367  C C   . ARG A 1 85  ? -33.54260 0.24313   -16.41085 1.000 65.22000  ? 203 ARG A C   1 
ATOM   368  O O   . ARG A 1 85  ? -32.75552 0.46602   -17.33958 1.000 59.28000  ? 203 ARG A O   1 
ATOM   369  C CB  . ARG A 1 85  ? -32.91056 -0.77489  -14.20433 1.000 62.01000  ? 203 ARG A CB  1 
ATOM   370  C CG  . ARG A 1 85  ? -32.67092 -0.58666  -12.71818 1.000 70.83000  ? 203 ARG A CG  1 
ATOM   371  C CD  . ARG A 1 85  ? -31.82955 -1.69766  -12.08667 1.000 80.71000  ? 203 ARG A CD  1 
ATOM   372  N NE  . ARG A 1 85  ? -31.52794 -1.38835  -10.68744 1.000 77.67000  ? 203 ARG A NE  1 
ATOM   373  C CZ  . ARG A 1 85  ? -32.38505 -1.56631  -9.68770  1.000 71.65000  ? 203 ARG A CZ  1 
ATOM   374  N NH1 . ARG A 1 85  ? -33.58378 -2.07469  -9.93322  1.000 75.84000  ? 203 ARG A NH1 1 
ATOM   375  N NH2 . ARG A 1 85  ? -32.04342 -1.25589  -8.44345  1.000 70.62000  ? 203 ARG A NH2 1 
ATOM   376  N N   . LYS A 1 86  ? -34.77235 -0.22928  -16.62436 1.000 72.81000  ? 204 LYS A N   1 
ATOM   377  C CA  . LYS A 1 86  ? -35.25202 -0.41169  -17.99155 1.000 73.03000  ? 204 LYS A CA  1 
ATOM   378  C C   . LYS A 1 86  ? -35.17245 0.89481   -18.77977 1.000 68.21000  ? 204 LYS A C   1 
ATOM   379  O O   . LYS A 1 86  ? -34.80423 0.89466   -19.96070 1.000 72.25000  ? 204 LYS A O   1 
ATOM   380  C CB  . LYS A 1 86  ? -36.68278 -0.96832  -17.98714 1.000 66.31000  ? 204 LYS A CB  1 
ATOM   381  C CG  . LYS A 1 86  ? -36.92343 -2.16298  -17.05189 1.000 69.57000  ? 204 LYS A CG  1 
ATOM   382  N N   . ASP A 1 87  ? -35.48606 2.02329   -18.13017 1.000 68.49000  ? 205 ASP A N   1 
ATOM   383  C CA  . ASP A 1 87  ? -35.54550 3.31267   -18.82042 1.000 62.57000  ? 205 ASP A CA  1 
ATOM   384  C C   . ASP A 1 87  ? -34.18159 3.73558   -19.34592 1.000 60.67000  ? 205 ASP A C   1 
ATOM   385  O O   . ASP A 1 87  ? -34.09869 4.41422   -20.37651 1.000 57.53000  ? 205 ASP A O   1 
ATOM   386  C CB  . ASP A 1 87  ? -36.08414 4.39188   -17.87988 1.000 54.68000  ? 205 ASP A CB  1 
ATOM   387  C CG  . ASP A 1 87  ? -37.60516 4.35112   -17.71919 1.000 58.46000  ? 205 ASP A CG  1 
ATOM   388  O OD1 . ASP A 1 87  ? -38.32074 3.76931   -18.57866 1.000 56.94000  ? 205 ASP A OD1 1 
ATOM   389  O OD2 . ASP A 1 87  ? -38.08159 4.92432   -16.71494 1.000 52.64000  ? 205 ASP A OD2 1 
ATOM   390  N N   . LEU A 1 88  ? -33.11053 3.32065   -18.66596 1.000 59.13000  ? 206 LEU A N   1 
ATOM   391  C CA  . LEU A 1 88  ? -31.76170 3.80938   -18.90543 1.000 58.07000  ? 206 LEU A CA  1 
ATOM   392  C C   . LEU A 1 88  ? -30.83314 2.82119   -19.60284 1.000 63.97000  ? 206 LEU A C   1 
ATOM   393  O O   . LEU A 1 88  ? -29.76924 3.24393   -20.07039 1.000 61.90000  ? 206 LEU A O   1 
ATOM   394  C CB  . LEU A 1 88  ? -31.12312 4.20387   -17.57008 1.000 54.27000  ? 206 LEU A CB  1 
ATOM   395  C CG  . LEU A 1 88  ? -31.56581 5.52633   -16.96838 1.000 58.97000  ? 206 LEU A CG  1 
ATOM   396  C CD1 . LEU A 1 88  ? -30.77817 5.79992   -15.69608 1.000 58.77000  ? 206 LEU A CD1 1 
ATOM   397  C CD2 . LEU A 1 88  ? -31.31710 6.61204   -17.99070 1.000 62.28000  ? 206 LEU A CD2 1 
ATOM   398  N N   . CYS A 1 89  ? -31.19056 1.52909   -19.68666 1.000 67.72000  ? 207 CYS A N   1 
ATOM   399  C CA  . CYS A 1 89  ? -30.18405 0.50670   -19.97408 1.000 66.25000  ? 207 CYS A CA  1 
ATOM   400  C C   . CYS A 1 89  ? -29.78377 0.48473   -21.44302 1.000 67.99000  ? 207 CYS A C   1 
ATOM   401  O O   . CYS A 1 89  ? -28.63157 0.15642   -21.75500 1.000 67.91000  ? 207 CYS A O   1 
ATOM   402  C CB  . CYS A 1 89  ? -30.66252 -0.89377  -19.53299 1.000 64.22000  ? 207 CYS A CB  1 
ATOM   403  S SG  . CYS A 1 89  ? -31.84591 -1.82165  -20.62175 1.000 76.34000  ? 207 CYS A SG  1 
ATOM   404  N N   . SER A 1 90  ? -30.70276 0.82787   -22.35198 1.000 69.03000  ? 208 SER A N   1 
ATOM   405  C CA  . SER A 1 90  ? -30.42548 0.81283   -23.78494 1.000 65.04000  ? 208 SER A CA  1 
ATOM   406  C C   . SER A 1 90  ? -30.03299 2.19032   -24.32006 1.000 65.91000  ? 208 SER A C   1 
ATOM   407  O O   . SER A 1 90  ? -29.88484 2.35509   -25.53094 1.000 62.51000  ? 208 SER A O   1 
ATOM   408  C CB  . SER A 1 90  ? -31.63210 0.26575   -24.55649 1.000 61.75000  ? 208 SER A CB  1 
ATOM   409  O OG  . SER A 1 90  ? -32.06164 -0.99973  -24.06131 1.000 69.35000  ? 208 SER A OG  1 
ATOM   410  N N   . LEU A 1 91  ? -29.85458 3.17788   -23.44445 1.000 66.62000  ? 209 LEU A N   1 
ATOM   411  C CA  . LEU A 1 91  ? -29.47810 4.53027   -23.83158 1.000 63.46000  ? 209 LEU A CA  1 
ATOM   412  C C   . LEU A 1 91  ? -28.06734 4.87561   -23.35112 1.000 66.06000  ? 209 LEU A C   1 
ATOM   413  O O   . LEU A 1 91  ? -27.74390 6.04862   -23.12937 1.000 64.94000  ? 209 LEU A O   1 
ATOM   414  C CB  . LEU A 1 91  ? -30.49764 5.52951   -23.28719 1.000 60.06000  ? 209 LEU A CB  1 
ATOM   415  C CG  . LEU A 1 91  ? -31.96346 5.25707   -23.63362 1.000 83.45000  ? 209 LEU A CG  1 
ATOM   416  C CD1 . LEU A 1 91  ? -32.86303 6.27729   -22.97718 1.000 69.09000  ? 209 LEU A CD1 1 
ATOM   417  C CD2 . LEU A 1 91  ? -32.17919 5.26385   -25.12465 1.000 82.05000  ? 209 LEU A CD2 1 
ATOM   418  N N   . LYS A 1 92  ? -27.22293 3.85988   -23.17856 1.000 64.03000  ? 210 LYS A N   1 
ATOM   419  C CA  . LYS A 1 92  ? -25.90312 4.03411   -22.58421 1.000 63.29000  ? 210 LYS A CA  1 
ATOM   420  C C   . LYS A 1 92  ? -24.88306 4.36419   -23.67383 1.000 58.31000  ? 210 LYS A C   1 
ATOM   421  O O   . LYS A 1 92  ? -24.78656 3.65783   -24.68423 1.000 56.08000  ? 210 LYS A O   1 
ATOM   422  C CB  . LYS A 1 92  ? -25.49471 2.77083   -21.80788 1.000 52.17000  ? 210 LYS A CB  1 
ATOM   423  N N   . VAL A 1 93  ? -24.12557 5.44041   -23.47306 1.000 54.09000  ? 211 VAL A N   1 
ATOM   424  C CA  . VAL A 1 93  ? -23.04155 5.79142   -24.38165 1.000 52.51000  ? 211 VAL A CA  1 
ATOM   425  C C   . VAL A 1 93  ? -21.74575 5.89952   -23.59535 1.000 53.06000  ? 211 VAL A C   1 
ATOM   426  O O   . VAL A 1 93  ? -21.73414 6.29984   -22.42611 1.000 48.45000  ? 211 VAL A O   1 
ATOM   427  C CB  . VAL A 1 93  ? -23.29000 7.11976   -25.14292 1.000 56.23000  ? 211 VAL A CB  1 
ATOM   428  C CG1 . VAL A 1 93  ? -24.54981 7.05770   -25.99519 1.000 53.52000  ? 211 VAL A CG1 1 
ATOM   429  C CG2 . VAL A 1 93  ? -23.35269 8.28915   -24.15924 1.000 51.28000  ? 211 VAL A CG2 1 
ATOM   430  N N   . SER A 1 94  ? -20.64348 5.55939   -24.25435 1.000 51.92000  ? 212 SER A N   1 
ATOM   431  C CA  . SER A 1 94  ? -19.36877 6.01665   -23.73284 1.000 52.59000  ? 212 SER A CA  1 
ATOM   432  C C   . SER A 1 94  ? -19.10231 7.45005   -24.21495 1.000 43.94000  ? 212 SER A C   1 
ATOM   433  O O   . SER A 1 94  ? -19.76737 7.96828   -25.10877 1.000 47.41000  ? 212 SER A O   1 
ATOM   434  C CB  . SER A 1 94  ? -18.24628 5.05638   -24.13820 1.000 47.62000  ? 212 SER A CB  1 
ATOM   435  O OG  . SER A 1 94  ? -17.87710 5.22534   -25.50103 1.000 65.57000  ? 212 SER A OG  1 
ATOM   436  N N   . LEU A 1 95  ? -18.12671 8.09811   -23.60339 1.000 42.17000  ? 213 LEU A N   1 
ATOM   437  C CA  . LEU A 1 95  ? -17.85228 9.50339   -23.85851 1.000 44.93000  ? 213 LEU A CA  1 
ATOM   438  C C   . LEU A 1 95  ? -16.39427 9.66225   -24.25015 1.000 51.18000  ? 213 LEU A C   1 
ATOM   439  O O   . LEU A 1 95  ? -15.51015 9.09626   -23.60032 1.000 54.28000  ? 213 LEU A O   1 
ATOM   440  C CB  . LEU A 1 95  ? -18.18187 10.33651  -22.62009 1.000 43.28000  ? 213 LEU A CB  1 
ATOM   441  C CG  . LEU A 1 95  ? -18.03853 11.85161  -22.66917 1.000 49.28000  ? 213 LEU A CG  1 
ATOM   442  C CD1 . LEU A 1 95  ? -19.20494 12.49068  -21.97001 1.000 51.18000  ? 213 LEU A CD1 1 
ATOM   443  C CD2 . LEU A 1 95  ? -16.78384 12.25573  -21.93970 1.000 60.42000  ? 213 LEU A CD2 1 
ATOM   444  N N   . GLN A 1 96  ? -16.14240 10.40000  -25.32667 1.000 50.66000  ? 214 GLN A N   1 
ATOM   445  C CA  . GLN A 1 96  ? -14.78747 10.72883  -25.73823 1.000 46.84000  ? 214 GLN A CA  1 
ATOM   446  C C   . GLN A 1 96  ? -14.60713 12.22990  -25.72431 1.000 50.69000  ? 214 GLN A C   1 
ATOM   447  O O   . GLN A 1 96  ? -15.51138 12.97074  -26.11705 1.000 52.93000  ? 214 GLN A O   1 
ATOM   448  C CB  . GLN A 1 96  ? -14.45498 10.20579  -27.11848 1.000 50.76000  ? 214 GLN A CB  1 
ATOM   449  C CG  . GLN A 1 96  ? -12.96892 10.14054  -27.28724 1.000 48.27000  ? 214 GLN A CG  1 
ATOM   450  C CD  . GLN A 1 96  ? -12.51757 9.94457   -28.69627 1.000 52.05000  ? 214 GLN A CD  1 
ATOM   451  O OE1 . GLN A 1 96  ? -12.51183 10.87305  -29.51072 1.000 55.77000  ? 214 GLN A OE1 1 
ATOM   452  N NE2 . GLN A 1 96  ? -12.14998 8.70991   -29.00993 1.000 45.61000  ? 214 GLN A NE2 1 
ATOM   453  N N   . LEU A 1 97  ? -13.44041 12.69316  -25.28783 1.000 49.38000  ? 215 LEU A N   1 
ATOM   454  C CA  . LEU A 1 97  ? -13.27307 14.13015  -25.14995 1.000 51.58000  ? 215 LEU A CA  1 
ATOM   455  C C   . LEU A 1 97  ? -11.87212 14.47406  -25.65049 1.000 50.12000  ? 215 LEU A C   1 
ATOM   456  O O   . LEU A 1 97  ? -10.88408 14.10012  -25.01453 1.000 54.45000  ? 215 LEU A O   1 
ATOM   457  C CB  . LEU A 1 97  ? -13.46051 14.52321  -23.68975 1.000 51.69000  ? 215 LEU A CB  1 
ATOM   458  C CG  . LEU A 1 97  ? -13.75420 15.99192  -23.41195 1.000 55.90000  ? 215 LEU A CG  1 
ATOM   459  C CD1 . LEU A 1 97  ? -14.46451 16.10580  -22.03901 1.000 66.65000  ? 215 LEU A CD1 1 
ATOM   460  C CD2 . LEU A 1 97  ? -12.66260 17.00754  -23.64915 1.000 59.25000  ? 215 LEU A CD2 1 
ATOM   461  N N   . ARG A 1 98  ? -11.77022 15.17177  -26.78206 1.000 45.86000  ? 216 ARG A N   1 
ATOM   462  C CA  A ARG A 1 98  ? -10.47226 15.50867  -27.35262 0.540 51.80000  ? 216 ARG A CA  1 
ATOM   463  C CA  B ARG A 1 98  ? -10.47226 15.51768  -27.36262 0.460 51.81000  ? 216 ARG A CA  1 
ATOM   464  C C   . ARG A 1 98  ? -9.96895  16.85959  -26.83774 1.000 53.99000  ? 216 ARG A C   1 
ATOM   465  O O   . ARG A 1 98  ? -10.72339 17.83722  -26.76230 1.000 51.65000  ? 216 ARG A O   1 
ATOM   466  C CB  A ARG A 1 98  ? -10.55597 15.48453  -28.87765 0.540 51.58000  ? 216 ARG A CB  1 
ATOM   467  C CB  B ARG A 1 98  ? -10.53500 15.55355  -28.89061 0.460 50.01000  ? 216 ARG A CB  1 
ATOM   468  C CG  A ARG A 1 98  ? -10.86726 14.07670  -29.39854 0.540 52.72000  ? 216 ARG A CG  1 
ATOM   469  C CG  B ARG A 1 98  ? -10.80929 14.20581  -29.54045 0.460 52.84000  ? 216 ARG A CG  1 
ATOM   470  C CD  A ARG A 1 98  ? -11.26895 14.00340  -30.88166 0.540 54.05000  ? 216 ARG A CD  1 
ATOM   471  C CD  B ARG A 1 98  ? -11.21207 14.32851  -31.02245 0.460 53.97000  ? 216 ARG A CD  1 
ATOM   472  N NE  A ARG A 1 98  ? -12.57315 14.59302  -31.21355 0.540 56.17000  ? 216 ARG A NE  1 
ATOM   473  N NE  B ARG A 1 98  ? -11.90355 15.57939  -31.34585 0.460 54.66000  ? 216 ARG A NE  1 
ATOM   474  C CZ  A ARG A 1 98  ? -13.75696 14.04334  -30.94009 0.540 49.85000  ? 216 ARG A CZ  1 
ATOM   475  C CZ  B ARG A 1 98  ? -11.44180 16.49409  -32.19423 0.460 51.09000  ? 216 ARG A CZ  1 
ATOM   476  N NH1 A ARG A 1 98  ? -13.82957 12.89293  -30.29178 0.540 44.65000  ? 216 ARG A NH1 1 
ATOM   477  N NH1 B ARG A 1 98  ? -12.13424 17.60193  -32.42570 0.460 47.63000  ? 216 ARG A NH1 1 
ATOM   478  N NH2 A ARG A 1 98  ? -14.87416 14.65807  -31.30994 0.540 49.57000  ? 216 ARG A NH2 1 
ATOM   479  N NH2 B ARG A 1 98  ? -10.28860 16.29696  -32.81413 0.460 52.71000  ? 216 ARG A NH2 1 
ATOM   480  N N   . GLY A 1 99  ? -8.68004  16.90394  -26.46347 1.000 55.87000  ? 217 GLY A N   1 
ATOM   481  C CA  . GLY A 1 99  ? -8.08566  18.12191  -25.96465 1.000 53.25000  ? 217 GLY A CA  1 
ATOM   482  C C   . GLY A 1 99  ? -7.37080  18.89286  -27.05906 1.000 60.88000  ? 217 GLY A C   1 
ATOM   483  O O   . GLY A 1 99  ? -6.97136  18.31363  -28.07433 1.000 58.63000  ? 217 GLY A O   1 
ATOM   484  N N   . GLU A 1 100 ? -7.23842  20.20979  -26.83826 1.000 68.57000  ? 218 GLU A N   1 
ATOM   485  C CA  . GLU A 1 100 ? -6.56662  21.07565  -27.80763 1.000 62.58000  ? 218 GLU A CA  1 
ATOM   486  C C   . GLU A 1 100 ? -5.15534  20.57545  -28.11067 1.000 68.50000  ? 218 GLU A C   1 
ATOM   487  O O   . GLU A 1 100 ? -4.70515  20.62733  -29.26355 1.000 64.50000  ? 218 GLU A O   1 
ATOM   488  C CB  . GLU A 1 100 ? -6.52834  22.51736  -27.28478 1.000 73.50000  ? 218 GLU A CB  1 
ATOM   489  C CG  . GLU A 1 100 ? -7.77167  23.38799  -27.57550 1.000 59.88000  ? 218 GLU A CG  1 
ATOM   490  N N   . ASP A 1 101 ? -4.45430  20.05616  -27.09084 1.000 66.00000  ? 219 ASP A N   1 
ATOM   491  C CA  . ASP A 1 101 ? -3.08606  19.56986  -27.26187 1.000 54.43000  ? 219 ASP A CA  1 
ATOM   492  C C   . ASP A 1 101 ? -2.99335  18.30639  -28.10360 1.000 60.51000  ? 219 ASP A C   1 
ATOM   493  O O   . ASP A 1 101 ? -1.89912  17.97615  -28.56859 1.000 76.45000  ? 219 ASP A O   1 
ATOM   494  C CB  . ASP A 1 101 ? -2.44020  19.31034  -25.89891 1.000 59.72000  ? 219 ASP A CB  1 
ATOM   495  C CG  . ASP A 1 101 ? -3.28897  18.40844  -24.99659 1.000 68.71000  ? 219 ASP A CG  1 
ATOM   496  O OD1 . ASP A 1 101 ? -4.11353  17.63038  -25.51520 1.000 58.05000  ? 219 ASP A OD1 1 
ATOM   497  O OD2 . ASP A 1 101 ? -3.14824  18.49577  -23.75352 1.000 68.59000  ? 219 ASP A OD2 1 
ATOM   498  N N   . GLY A 1 102 ? -4.09200  17.58703  -28.30622 1.000 56.14000  ? 220 GLY A N   1 
ATOM   499  C CA  . GLY A 1 102 ? -4.06431  16.29443  -28.96798 1.000 55.79000  ? 220 GLY A CA  1 
ATOM   500  C C   . GLY A 1 102 ? -4.33296  15.10978  -28.05472 1.000 62.36000  ? 220 GLY A C   1 
ATOM   501  O O   . GLY A 1 102 ? -4.46537  13.98201  -28.55141 1.000 59.55000  ? 220 GLY A O   1 
ATOM   502  N N   . SER A 1 103 ? -4.41030  15.33197  -26.74161 1.000 60.72000  ? 221 SER A N   1 
ATOM   503  C CA  . SER A 1 103 ? -4.78202  14.29725  -25.78428 1.000 59.13000  ? 221 SER A CA  1 
ATOM   504  C C   . SER A 1 103 ? -6.24081  13.88969  -25.92879 1.000 53.90000  ? 221 SER A C   1 
ATOM   505  O O   . SER A 1 103 ? -7.10410  14.69552  -26.27848 1.000 54.92000  ? 221 SER A O   1 
ATOM   506  C CB  . SER A 1 103 ? -4.56550  14.79450  -24.35595 1.000 59.65000  ? 221 SER A CB  1 
ATOM   507  O OG  . SER A 1 103 ? -5.20809  16.04910  -24.15233 1.000 63.64000  ? 221 SER A OG  1 
ATOM   508  N N   . VAL A 1 104 ? -6.51232  12.63138  -25.59658 1.000 55.60000  ? 222 VAL A N   1 
ATOM   509  C CA  . VAL A 1 104 ? -7.85207  12.05680  -25.61517 1.000 58.36000  ? 222 VAL A CA  1 
ATOM   510  C C   . VAL A 1 104 ? -8.18409  11.51984  -24.22654 1.000 56.41000  ? 222 VAL A C   1 
ATOM   511  O O   . VAL A 1 104 ? -7.43284  10.70984  -23.66788 1.000 55.95000  ? 222 VAL A O   1 
ATOM   512  C CB  . VAL A 1 104 ? -7.96638  10.93036  -26.65885 1.000 56.01000  ? 222 VAL A CB  1 
ATOM   513  C CG1 . VAL A 1 104 ? -9.42418  10.56286  -26.88834 1.000 51.62000  ? 222 VAL A CG1 1 
ATOM   514  C CG2 . VAL A 1 104 ? -7.30433  11.34241  -27.94749 1.000 57.39000  ? 222 VAL A CG2 1 
ATOM   515  N N   . TRP A 1 105 ? -9.31738  11.94903  -23.68850 1.000 52.07000  ? 223 TRP A N   1 
ATOM   516  C CA  . TRP A 1 105 ? -9.94432  11.32907  -22.52898 1.000 46.63000  ? 223 TRP A CA  1 
ATOM   517  C C   . TRP A 1 105 ? -11.15789 10.54082  -23.00867 1.000 46.51000  ? 223 TRP A C   1 
ATOM   518  O O   . TRP A 1 105 ? -12.00500 11.08787  -23.71850 1.000 53.66000  ? 223 TRP A O   1 
ATOM   519  C CB  . TRP A 1 105 ? -10.39897 12.38729  -21.53344 1.000 49.68000  ? 223 TRP A CB  1 
ATOM   520  C CG  . TRP A 1 105 ? -9.38139  12.94217  -20.57193 1.000 52.74000  ? 223 TRP A CG  1 
ATOM   521  C CD1 . TRP A 1 105 ? -8.82393  14.19243  -20.60809 1.000 52.16000  ? 223 TRP A CD1 1 
ATOM   522  C CD2 . TRP A 1 105 ? -8.86833  12.31170  -19.38820 1.000 50.88000  ? 223 TRP A CD2 1 
ATOM   523  N NE1 . TRP A 1 105 ? -7.97921  14.36718  -19.53783 1.000 56.36000  ? 223 TRP A NE1 1 
ATOM   524  C CE2 . TRP A 1 105 ? -7.99185  13.22972  -18.77150 1.000 55.17000  ? 223 TRP A CE2 1 
ATOM   525  C CE3 . TRP A 1 105 ? -9.06290  11.06326  -18.79297 1.000 49.04000  ? 223 TRP A CE3 1 
ATOM   526  C CZ2 . TRP A 1 105 ? -7.30694  12.93133  -17.58855 1.000 53.49000  ? 223 TRP A CZ2 1 
ATOM   527  C CZ3 . TRP A 1 105 ? -8.38399  10.77287  -17.61802 1.000 45.93000  ? 223 TRP A CZ3 1 
ATOM   528  C CH2 . TRP A 1 105 ? -7.51750  11.69791  -17.03132 1.000 45.83000  ? 223 TRP A CH2 1 
ATOM   529  N N   . ASN A 1 106 ? -11.23239 9.26157   -22.64643 1.000 52.51000  ? 224 ASN A N   1 
ATOM   530  C CA  A ASN A 1 106 ? -12.38197 8.41925   -22.94414 0.640 50.02000  ? 224 ASN A CA  1 
ATOM   531  C CA  B ASN A 1 106 ? -12.36296 8.38825   -22.94216 0.360 50.35000  ? 224 ASN A CA  1 
ATOM   532  C C   . ASN A 1 106 ? -13.03103 7.99719   -21.63051 1.000 53.59000  ? 224 ASN A C   1 
ATOM   533  O O   . ASN A 1 106 ? -12.34512 7.78790   -20.62650 1.000 56.42000  ? 224 ASN A O   1 
ATOM   534  C CB  A ASN A 1 106 ? -11.96228 7.19291   -23.77078 0.640 50.30000  ? 224 ASN A CB  1 
ATOM   535  C CB  B ASN A 1 106 ? -11.92026 7.10887   -23.66783 0.360 50.48000  ? 224 ASN A CB  1 
ATOM   536  C CG  A ASN A 1 106 ? -13.11981 6.24558   -24.06355 0.640 56.35000  ? 224 ASN A CG  1 
ATOM   537  C CG  B ASN A 1 106 ? -11.21314 7.38395   -24.97253 0.360 52.21000  ? 224 ASN A CG  1 
ATOM   538  O OD1 A ASN A 1 106 ? -14.00380 6.55466   -24.86754 0.640 55.69000  ? 224 ASN A OD1 1 
ATOM   539  O OD1 B ASN A 1 106 ? -11.29652 8.47423   -25.50991 0.360 55.23000  ? 224 ASN A OD1 1 
ATOM   540  N ND2 A ASN A 1 106 ? -13.11742 5.07920   -23.41024 0.640 56.60000  ? 224 ASN A ND2 1 
ATOM   541  N ND2 B ASN A 1 106 ? -10.49661 6.38956   -25.48299 0.360 56.89000  ? 224 ASN A ND2 1 
ATOM   542  N N   . TYR A 1 107 ? -14.36298 7.88860   -21.62682 1.000 47.91000  ? 225 TYR A N   1 
ATOM   543  C CA  . TYR A 1 107 ? -15.09200 7.43759   -20.43922 1.000 45.90000  ? 225 TYR A CA  1 
ATOM   544  C C   . TYR A 1 107 ? -16.04644 6.30638   -20.80906 1.000 46.73000  ? 225 TYR A C   1 
ATOM   545  O O   . TYR A 1 107 ? -16.97939 6.51643   -21.58811 1.000 52.11000  ? 225 TYR A O   1 
ATOM   546  C CB  . TYR A 1 107 ? -15.85763 8.58887   -19.78368 1.000 42.28000  ? 225 TYR A CB  1 
ATOM   547  C CG  . TYR A 1 107 ? -16.76365 8.15180   -18.63811 1.000 52.87000  ? 225 TYR A CG  1 
ATOM   548  C CD1 . TYR A 1 107 ? -18.07441 7.71136   -18.87161 1.000 48.17000  ? 225 TYR A CD1 1 
ATOM   549  C CD2 . TYR A 1 107 ? -16.31891 8.19422   -17.31800 1.000 54.52000  ? 225 TYR A CD2 1 
ATOM   550  C CE1 . TYR A 1 107 ? -18.89743 7.29938   -17.82700 1.000 47.89000  ? 225 TYR A CE1 1 
ATOM   551  C CE2 . TYR A 1 107 ? -17.13593 7.78724   -16.26639 1.000 48.49000  ? 225 TYR A CE2 1 
ATOM   552  C CZ  . TYR A 1 107 ? -18.42369 7.34283   -16.52489 1.000 52.75000  ? 225 TYR A CZ  1 
ATOM   553  O OH  . TYR A 1 107 ? -19.22771 6.94885   -15.46827 1.000 57.20000  ? 225 TYR A OH  1 
ATOM   554  N N   . LYS A 1 108 ? -15.82101 5.07714   -20.23074 1.000 46.27000  ? 226 LYS A N   1 
ATOM   555  C CA  . LYS A 1 108 ? -16.80751 4.00381   -20.40155 1.000 48.98000  ? 226 LYS A CA  1 
ATOM   556  C C   . LYS A 1 108 ? -17.71071 3.94469   -19.17475 1.000 56.47000  ? 226 LYS A C   1 
ATOM   557  O O   . LYS A 1 108 ? -17.20394 3.99925   -18.04063 1.000 59.89000  ? 226 LYS A O   1 
ATOM   558  C CB  . LYS A 1 108 ? -16.12887 2.65123   -20.61522 1.000 39.85000  ? 226 LYS A CB  1 
ATOM   559  N N   . PRO A 1 109 ? -19.03064 3.86521   -19.33404 1.000 51.34000  ? 227 PRO A N   1 
ATOM   560  C CA  . PRO A 1 109 ? -19.92687 3.89513   -18.16919 1.000 55.83000  ? 227 PRO A CA  1 
ATOM   561  C C   . PRO A 1 109 ? -19.90243 2.56771   -17.43297 1.000 61.31000  ? 227 PRO A C   1 
ATOM   562  O O   . PRO A 1 109 ? -19.53686 1.52921   -18.01151 1.000 60.81000  ? 227 PRO A O   1 
ATOM   563  C CB  . PRO A 1 109 ? -21.30487 4.16190   -18.79429 1.000 50.01000  ? 227 PRO A CB  1 
ATOM   564  C CG  . PRO A 1 109 ? -21.21435 3.52472   -20.13665 1.000 53.27000  ? 227 PRO A CG  1 
ATOM   565  C CD  . PRO A 1 109 ? -19.77935 3.73462   -20.59726 1.000 55.85000  ? 227 PRO A CD  1 
ATOM   566  N N   . PRO A 1 110 ? -20.26766 2.55280   -16.15304 1.000 62.94000  ? 228 PRO A N   1 
ATOM   567  C CA  . PRO A 1 110 ? -20.26924 1.28637   -15.41879 1.000 62.56000  ? 228 PRO A CA  1 
ATOM   568  C C   . PRO A 1 110 ? -21.39576 0.39515   -15.90052 1.000 68.00000  ? 228 PRO A C   1 
ATOM   569  O O   . PRO A 1 110 ? -22.44289 0.87696   -16.34743 1.000 66.70000  ? 228 PRO A O   1 
ATOM   570  C CB  . PRO A 1 110 ? -20.46770 1.71642   -13.95857 1.000 64.47000  ? 228 PRO A CB  1 
ATOM   571  C CG  . PRO A 1 110 ? -21.10927 3.06218   -14.02590 1.000 55.55000  ? 228 PRO A CG  1 
ATOM   572  C CD  . PRO A 1 110 ? -20.57832 3.70315   -15.28042 1.000 61.70000  ? 228 PRO A CD  1 
ATOM   573  N N   . ALA A 1 111 ? -21.15720 -0.91678  -15.83425 1.000 76.27000  ? 229 ALA A N   1 
ATOM   574  C CA  . ALA A 1 111 ? -22.22773 -1.88713  -16.04401 1.000 76.92000  ? 229 ALA A CA  1 
ATOM   575  C C   . ALA A 1 111 ? -23.22297 -1.83524  -14.88817 1.000 81.98000  ? 229 ALA A C   1 
ATOM   576  O O   . ALA A 1 111 ? -22.87433 -1.50076  -13.74891 1.000 79.63000  ? 229 ALA A O   1 
ATOM   577  C CB  . ALA A 1 111 ? -21.67109 -3.30280  -16.18374 1.000 63.80000  ? 229 ALA A CB  1 
ATOM   578  N N   . ASP A 1 112 ? -24.48077 -2.14961  -15.20058 1.000 76.78000  ? 230 ASP A N   1 
ATOM   579  C CA  . ASP A 1 112 ? -25.55000 -2.05866  -14.21373 1.000 81.00000  ? 230 ASP A CA  1 
ATOM   580  C C   . ASP A 1 112 ? -25.32777 -3.05623  -13.07727 1.000 89.21000  ? 230 ASP A C   1 
ATOM   581  O O   . ASP A 1 112 ? -25.54721 -4.26323  -13.24502 1.000 86.10000  ? 230 ASP A O   1 
ATOM   582  C CB  . ASP A 1 112 ? -26.90677 -2.28285  -14.89311 1.000 80.43000  ? 230 ASP A CB  1 
ATOM   583  C CG  . ASP A 1 112 ? -28.08910 -1.91090  -13.99911 1.000 84.30000  ? 230 ASP A CG  1 
ATOM   584  O OD1 . ASP A 1 112 ? -27.87755 -1.36145  -12.89275 1.000 82.76000  ? 230 ASP A OD1 1 
ATOM   585  O OD2 . ASP A 1 112 ? -29.23891 -2.17716  -14.40848 1.000 89.92000  ? 230 ASP A OD2 1 
ATOM   586  N N   . SER A 1 113 ? -24.87120 -2.55970  -11.92490 1.000 83.06000  ? 231 SER A N   1 
ATOM   587  C CA  . SER A 1 113 ? -24.72007 -3.35735  -10.71634 1.000 79.79000  ? 231 SER A CA  1 
ATOM   588  C C   . SER A 1 113 ? -25.87634 -3.15443  -9.73643  1.000 90.85000  ? 231 SER A C   1 
ATOM   589  O O   . SER A 1 113 ? -25.75240 -3.52407  -8.56262  1.000 87.23000  ? 231 SER A O   1 
ATOM   590  C CB  . SER A 1 113 ? -23.38534 -3.03616  -10.03590 1.000 68.08000  ? 231 SER A CB  1 
ATOM   591  N N   . GLY A 1 114 ? -26.98352 -2.55465  -10.18728 1.000 94.76000  ? 232 GLY A N   1 
ATOM   592  C CA  . GLY A 1 114 ? -28.17774 -2.39265  -9.37241  1.000 83.55000  ? 232 GLY A CA  1 
ATOM   593  C C   . GLY A 1 114 ? -28.21344 -1.19622  -8.43871  1.000 88.57000  ? 232 GLY A C   1 
ATOM   594  O O   . GLY A 1 114 ? -29.04762 -1.16712  -7.52685  1.000 85.68000  ? 232 GLY A O   1 
ATOM   595  N N   . GLY A 1 115 ? -27.35184 -0.19572  -8.63796  1.000 84.22000  ? 233 GLY A N   1 
ATOM   596  C CA  . GLY A 1 115 ? -27.31251 0.94777   -7.74029  1.000 78.88000  ? 233 GLY A CA  1 
ATOM   597  C C   . GLY A 1 115 ? -27.26998 2.30819   -8.42048  1.000 77.47000  ? 233 GLY A C   1 
ATOM   598  O O   . GLY A 1 115 ? -27.57081 2.42375   -9.61147  1.000 74.72000  ? 233 GLY A O   1 
ATOM   599  N N   . LYS A 1 116 ? -26.88357 3.34992   -7.67680  1.000 74.50000  ? 234 LYS A N   1 
ATOM   600  C CA  . LYS A 1 116 ? -26.92708 4.71321   -8.19800  1.000 74.84000  ? 234 LYS A CA  1 
ATOM   601  C C   . LYS A 1 116 ? -25.91998 4.96331   -9.31667  1.000 69.94000  ? 234 LYS A C   1 
ATOM   602  O O   . LYS A 1 116 ? -25.95633 6.03465   -9.93505  1.000 68.14000  ? 234 LYS A O   1 
ATOM   603  C CB  . LYS A 1 116 ? -26.70473 5.72264   -7.06037  1.000 71.97000  ? 234 LYS A CB  1 
ATOM   604  N N   . GLU A 1 117 ? -25.03951 4.00586   -9.60307  1.000 70.95000  ? 235 GLU A N   1 
ATOM   605  C CA  . GLU A 1 117 ? -24.00240 4.19391   -10.61377 1.000 69.73000  ? 235 GLU A CA  1 
ATOM   606  C C   . GLU A 1 117 ? -24.56120 4.33549   -12.02779 1.000 66.55000  ? 235 GLU A C   1 
ATOM   607  O O   . GLU A 1 117 ? -23.85125 4.82733   -12.91337 1.000 68.09000  ? 235 GLU A O   1 
ATOM   608  C CB  . GLU A 1 117 ? -23.02489 3.01631   -10.56828 1.000 77.28000  ? 235 GLU A CB  1 
ATOM   609  C CG  . GLU A 1 117 ? -23.65023 1.68128   -10.97918 1.000 72.59000  ? 235 GLU A CG  1 
ATOM   610  C CD  . GLU A 1 117 ? -24.26012 0.93032   -9.80673  1.000 79.99000  ? 235 GLU A CD  1 
ATOM   611  O OE1 . GLU A 1 117 ? -24.96263 -0.08285  -10.04946 1.000 76.86000  ? 235 GLU A OE1 1 
ATOM   612  O OE2 . GLU A 1 117 ? -24.03052 1.35774   -8.64744  1.000 82.56000  ? 235 GLU A OE2 1 
ATOM   613  N N   . ILE A 1 118 ? -25.80197 3.90809   -12.26227 1.000 59.58000  ? 236 ILE A N   1 
ATOM   614  C CA  . ILE A 1 118 ? -26.45077 4.00957   -13.56633 1.000 58.92000  ? 236 ILE A CA  1 
ATOM   615  C C   . ILE A 1 118 ? -26.77835 5.46262   -13.89654 1.000 58.49000  ? 236 ILE A C   1 
ATOM   616  O O   . ILE A 1 118 ? -27.28628 5.76704   -14.98545 1.000 57.07000  ? 236 ILE A O   1 
ATOM   617  C CB  . ILE A 1 118 ? -27.72739 3.14803   -13.60407 1.000 60.24000  ? 236 ILE A CB  1 
ATOM   618  C CG1 . ILE A 1 118 ? -28.71880 3.62796   -12.52697 1.000 62.08000  ? 236 ILE A CG1 1 
ATOM   619  C CG2 . ILE A 1 118 ? -27.36879 1.69307   -13.40386 1.000 52.47000  ? 236 ILE A CG2 1 
ATOM   620  C CD1 . ILE A 1 118 ? -30.17058 3.22746   -12.75248 1.000 61.76000  ? 236 ILE A CD1 1 
ATOM   621  N N   . PHE A 1 119 ? -26.50692 6.36519   -12.95396 1.000 55.70000  ? 237 PHE A N   1 
ATOM   622  C CA  . PHE A 1 119 ? -26.77551 7.78217   -13.12017 1.000 50.98000  ? 237 PHE A CA  1 
ATOM   623  C C   . PHE A 1 119 ? -25.53082 8.61189   -13.42745 1.000 52.07000  ? 237 PHE A C   1 
ATOM   624  O O   . PHE A 1 119 ? -25.64433 9.83292   -13.56676 1.000 55.16000  ? 237 PHE A O   1 
ATOM   625  C CB  . PHE A 1 119 ? -27.45098 8.33613   -11.86597 1.000 57.38000  ? 237 PHE A CB  1 
ATOM   626  C CG  . PHE A 1 119 ? -28.69174 7.59434   -11.44764 1.000 63.90000  ? 237 PHE A CG  1 
ATOM   627  C CD1 . PHE A 1 119 ? -29.76551 7.44938   -12.31892 1.000 62.06000  ? 237 PHE A CD1 1 
ATOM   628  C CD2 . PHE A 1 119 ? -28.81175 7.08954   -10.16395 1.000 64.79000  ? 237 PHE A CD2 1 
ATOM   629  C CE1 . PHE A 1 119 ? -30.92730 6.79064   -11.92252 1.000 53.89000  ? 237 PHE A CE1 1 
ATOM   630  C CE2 . PHE A 1 119 ? -29.96254 6.43280   -9.76755  1.000 64.99000  ? 237 PHE A CE2 1 
ATOM   631  C CZ  . PHE A 1 119 ? -31.02231 6.28585   -10.64884 1.000 58.33000  ? 237 PHE A CZ  1 
ATOM   632  N N   . SER A 1 120 ? -24.36351 7.98149   -13.57661 1.000 52.38000  ? 238 SER A N   1 
ATOM   633  C CA  . SER A 1 120 ? -23.09083 8.70605   -13.58595 1.000 48.68000  ? 238 SER A CA  1 
ATOM   634  C C   . SER A 1 120 ? -23.00608 9.75274   -14.69332 1.000 49.00000  ? 238 SER A C   1 
ATOM   635  O O   . SER A 1 120 ? -22.32456 10.77295  -14.53259 1.000 51.71000  ? 238 SER A O   1 
ATOM   636  C CB  . SER A 1 120 ? -21.94037 7.71665   -13.73332 1.000 47.05000  ? 238 SER A CB  1 
ATOM   637  O OG  . SER A 1 120 ? -22.09082 6.96328   -14.92279 1.000 52.28000  ? 238 SER A OG  1 
ATOM   638  N N   . LEU A 1 121 ? -23.66177 9.51412   -15.82358 1.000 44.51000  ? 239 LEU A N   1 
ATOM   639  C CA  . LEU A 1 121 ? -23.61796 10.42580  -16.95504 1.000 43.54000  ? 239 LEU A CA  1 
ATOM   640  C C   . LEU A 1 121 ? -24.78039 11.41732  -16.99267 1.000 47.73000  ? 239 LEU A C   1 
ATOM   641  O O   . LEU A 1 121 ? -24.74064 12.34681  -17.80212 1.000 44.43000  ? 239 LEU A O   1 
ATOM   642  C CB  . LEU A 1 121 ? -23.59237 9.63058   -18.26650 1.000 44.98000  ? 239 LEU A CB  1 
ATOM   643  C CG  . LEU A 1 121 ? -22.19511 9.25649   -18.76046 1.000 48.02000  ? 239 LEU A CG  1 
ATOM   644  C CD1 . LEU A 1 121 ? -22.27056 8.56124   -20.09288 1.000 49.82000  ? 239 LEU A CD1 1 
ATOM   645  C CD2 . LEU A 1 121 ? -21.29464 10.49894  -18.85656 1.000 46.10000  ? 239 LEU A CD2 1 
ATOM   646  N N   . LEU A 1 122 ? -25.80048 11.26437  -16.14295 1.000 43.41000  ? 240 LEU A N   1 
ATOM   647  C CA  . LEU A 1 122 ? -26.94186 12.16792  -16.23563 1.000 46.15000  ? 240 LEU A CA  1 
ATOM   648  C C   . LEU A 1 122 ? -26.59054 13.63794  -15.99570 1.000 49.49000  ? 240 LEU A C   1 
ATOM   649  O O   . LEU A 1 122 ? -27.14079 14.49312  -16.71430 1.000 50.62000  ? 240 LEU A O   1 
ATOM   650  C CB  . LEU A 1 122 ? -28.05383 11.70388  -15.29310 1.000 44.81000  ? 240 LEU A CB  1 
ATOM   651  C CG  . LEU A 1 122 ? -28.70817 10.39185  -15.72100 1.000 46.45000  ? 240 LEU A CG  1 
ATOM   652  C CD1 . LEU A 1 122 ? -29.93421 10.11981  -14.86338 1.000 48.95000  ? 240 LEU A CD1 1 
ATOM   653  C CD2 . LEU A 1 122 ? -29.05590 10.39756  -17.19706 1.000 41.84000  ? 240 LEU A CD2 1 
ATOM   654  N N   . PRO A 1 123 ? -25.71988 14.01376  -15.04632 1.000 48.00000  ? 241 PRO A N   1 
ATOM   655  C CA  . PRO A 1 123 ? -25.37453 15.44386  -14.94841 1.000 40.76000  ? 241 PRO A CA  1 
ATOM   656  C C   . PRO A 1 123 ? -24.72853 15.96788  -16.20999 1.000 46.18000  ? 241 PRO A C   1 
ATOM   657  O O   . PRO A 1 123 ? -25.04193 17.08401  -16.65939 1.000 48.49000  ? 241 PRO A O   1 
ATOM   658  C CB  . PRO A 1 123 ? -24.41378 15.49957  -13.74820 1.000 36.36000  ? 241 PRO A CB  1 
ATOM   659  C CG  . PRO A 1 123 ? -24.81041 14.31491  -12.91197 1.000 35.10000  ? 241 PRO A CG  1 
ATOM   660  C CD  . PRO A 1 123 ? -25.11975 13.24237  -13.93466 1.000 44.05000  ? 241 PRO A CD  1 
ATOM   661  N N   . HIS A 1 124 ? -23.83307 15.19263  -16.81628 1.000 49.21000  ? 242 HIS A N   1 
ATOM   662  C CA  . HIS A 1 124 ? -23.24305 15.66562  -18.06189 1.000 48.76000  ? 242 HIS A CA  1 
ATOM   663  C C   . HIS A 1 124 ? -24.30092 15.82779  -19.14099 1.000 46.38000  ? 242 HIS A C   1 
ATOM   664  O O   . HIS A 1 124 ? -24.30122 16.81323  -19.88641 1.000 43.82000  ? 242 HIS A O   1 
ATOM   665  C CB  . HIS A 1 124 ? -22.16554 14.72439  -18.56324 1.000 42.82000  ? 242 HIS A CB  1 
ATOM   666  C CG  . HIS A 1 124 ? -21.57051 15.18840  -19.84886 1.000 42.68000  ? 242 HIS A CG  1 
ATOM   667  N ND1 . HIS A 1 124 ? -20.81900 16.33978  -19.93505 1.000 51.88000  ? 242 HIS A ND1 1 
ATOM   668  C CD2 . HIS A 1 124 ? -21.65806 14.70010  -21.10616 1.000 42.69000  ? 242 HIS A CD2 1 
ATOM   669  C CE1 . HIS A 1 124 ? -20.45185 16.53068  -21.18787 1.000 46.68000  ? 242 HIS A CE1 1 
ATOM   670  N NE2 . HIS A 1 124 ? -20.94628 15.54789  -21.91853 1.000 46.16000  ? 242 HIS A NE2 1 
ATOM   671  N N   . MET A 1 125 ? -25.21548 14.87145  -19.24072 1.000 47.47000  ? 243 MET A N   1 
ATOM   672  C CA  A MET A 1 125 ? -26.21934 14.98062  -20.28284 0.400 46.15000  ? 243 MET A CA  1 
ATOM   673  C CA  B MET A 1 125 ? -26.25833 14.94459  -20.25887 0.600 48.65000  ? 243 MET A CA  1 
ATOM   674  C C   . MET A 1 125 ? -27.19989 16.10803  -20.00336 1.000 45.21000  ? 243 MET A C   1 
ATOM   675  O O   . MET A 1 125 ? -27.65200 16.76038  -20.94506 1.000 43.74000  ? 243 MET A O   1 
ATOM   676  C CB  A MET A 1 125 ? -26.91472 13.64141  -20.45176 0.400 47.21000  ? 243 MET A CB  1 
ATOM   677  C CB  B MET A 1 125 ? -27.03474 13.63328  -20.31078 0.600 47.04000  ? 243 MET A CB  1 
ATOM   678  C CG  A MET A 1 125 ? -26.03417 12.70426  -21.23115 0.400 49.71000  ? 243 MET A CG  1 
ATOM   679  C CG  B MET A 1 125 ? -26.13421 12.44773  -20.41531 0.600 49.00000  ? 243 MET A CG  1 
ATOM   680  S SD  A MET A 1 125 ? -26.70942 11.06506  -21.39723 0.400 52.70000  ? 243 MET A SD  1 
ATOM   681  S SD  B MET A 1 125 ? -25.59375 12.11796  -22.09441 0.600 52.70000  ? 243 MET A SD  1 
ATOM   682  C CE  A MET A 1 125 ? -25.30392 10.24811  -22.13345 0.400 57.83000  ? 243 MET A CE  1 
ATOM   683  C CE  B MET A 1 125 ? -25.86997 10.34786  -22.13650 0.600 58.28000  ? 243 MET A CE  1 
ATOM   684  N N   . ALA A 1 126 ? -27.51324 16.37014  -18.72926 1.000 44.49000  ? 244 ALA A N   1 
ATOM   685  C CA  . ALA A 1 126 ? -28.34980 17.51758  -18.40374 1.000 43.95000  ? 244 ALA A CA  1 
ATOM   686  C C   . ALA A 1 126 ? -27.72727 18.80416  -18.91587 1.000 44.53000  ? 244 ALA A C   1 
ATOM   687  O O   . ALA A 1 126 ? -28.42153 19.65019  -19.49951 1.000 45.56000  ? 244 ALA A O   1 
ATOM   688  C CB  . ALA A 1 126 ? -28.57512 17.60660  -16.89773 1.000 40.70000  ? 244 ALA A CB  1 
ATOM   689  N N   . ASP A 1 127 ? -26.41337 18.96262  -18.72754 1.000 44.06000  ? 245 ASP A N   1 
ATOM   690  C CA  . ASP A 1 127 ? -25.73379 20.14123  -19.25572 1.000 37.68000  ? 245 ASP A CA  1 
ATOM   691  C C   . ASP A 1 127 ? -25.74151 20.14612  -20.78172 1.000 36.05000  ? 245 ASP A C   1 
ATOM   692  O O   . ASP A 1 127 ? -25.96886 21.19038  -21.39515 1.000 42.44000  ? 245 ASP A O   1 
ATOM   693  C CB  . ASP A 1 127 ? -24.30893 20.21753  -18.70041 1.000 35.81000  ? 245 ASP A CB  1 
ATOM   694  C CG  . ASP A 1 127 ? -24.29027 20.35164  -17.17533 1.000 44.71000  ? 245 ASP A CG  1 
ATOM   695  O OD1 . ASP A 1 127 ? -25.34253 20.70784  -16.59531 1.000 45.89000  ? 245 ASP A OD1 1 
ATOM   696  O OD2 . ASP A 1 127 ? -23.23627 20.09673  -16.54428 1.000 41.75000  ? 245 ASP A OD2 1 
ATOM   697  N N   . MET A 1 128 ? -25.51789 18.99260  -21.42036 1.000 40.90000  ? 246 MET A N   1 
ATOM   698  C CA  . MET A 1 128 ? -25.54060 18.96345  -22.88538 1.000 42.11000  ? 246 MET A CA  1 
ATOM   699  C C   . MET A 1 128 ? -26.93364 19.28415  -23.42645 1.000 42.29000  ? 246 MET A C   1 
ATOM   700  O O   . MET A 1 128 ? -27.07282 20.08264  -24.36700 1.000 40.60000  ? 246 MET A O   1 
ATOM   701  C CB  . MET A 1 128 ? -25.06691 17.60696  -23.41409 1.000 38.43000  ? 246 MET A CB  1 
ATOM   702  C CG  . MET A 1 128 ? -25.24155 17.42578  -24.93523 1.000 34.28000  ? 246 MET A CG  1 
ATOM   703  S SD  . MET A 1 128 ? -24.50694 18.75170  -25.95131 1.000 41.39000  ? 246 MET A SD  1 
ATOM   704  C CE  . MET A 1 128 ? -22.81367 18.22357  -26.16831 1.000 36.42000  ? 246 MET A CE  1 
ATOM   705  N N   . SER A 1 129 ? -27.97649 18.68035  -22.84399 1.000 38.08000  ? 247 SER A N   1 
ATOM   706  C CA  . SER A 1 129 ? -29.33752 18.93803  -23.30409 1.000 37.35000  ? 247 SER A CA  1 
ATOM   707  C C   . SER A 1 129 ? -29.75820 20.37969  -23.03932 1.000 40.90000  ? 247 SER A C   1 
ATOM   708  O O   . SER A 1 129 ? -30.33632 21.03295  -23.91905 1.000 38.70000  ? 247 SER A O   1 
ATOM   709  C CB  . SER A 1 129 ? -30.29721 17.95622  -22.64685 1.000 47.04000  ? 247 SER A CB  1 
ATOM   710  O OG  . SER A 1 129 ? -29.85058 16.62355  -22.87755 1.000 53.28000  ? 247 SER A OG  1 
ATOM   711  N N   . THR A 1 130 ? -29.45565 20.90112  -21.84496 1.000 45.34000  ? 248 THR A N   1 
ATOM   712  C CA  . THR A 1 130 ? -29.76432 22.29780  -21.53120 1.000 43.26000  ? 248 THR A CA  1 
ATOM   713  C C   . THR A 1 130 ? -29.08156 23.25867  -22.49851 1.000 38.65000  ? 248 THR A C   1 
ATOM   714  O O   . THR A 1 130 ? -29.69691 24.24066  -22.94204 1.000 42.87000  ? 248 THR A O   1 
ATOM   715  C CB  . THR A 1 130 ? -29.36072 22.60813  -20.08894 1.000 40.11000  ? 248 THR A CB  1 
ATOM   716  O OG1 . THR A 1 130 ? -30.09150 21.74030  -19.21359 1.000 37.74000  ? 248 THR A OG1 1 
ATOM   717  C CG2 . THR A 1 130 ? -29.61844 24.09381  -19.72812 1.000 33.70000  ? 248 THR A CG2 1 
ATOM   718  N N   . TYR A 1 131 ? -27.81238 23.00242  -22.83442 1.000 36.17000  ? 249 TYR A N   1 
ATOM   719  C CA  . TYR A 1 131 ? -27.14654 23.79932  -23.86283 1.000 36.31000  ? 249 TYR A CA  1 
ATOM   720  C C   . TYR A 1 131 ? -27.90426 23.71776  -25.18002 1.000 37.57000  ? 249 TYR A C   1 
ATOM   721  O O   . TYR A 1 131 ? -28.11759 24.73606  -25.84446 1.000 39.64000  ? 249 TYR A O   1 
ATOM   722  C CB  . TYR A 1 131 ? -25.69530 23.33507  -24.05384 1.000 35.96000  ? 249 TYR A CB  1 
ATOM   723  C CG  . TYR A 1 131 ? -24.94345 24.11302  -25.12124 1.000 33.61000  ? 249 TYR A CG  1 
ATOM   724  C CD1 . TYR A 1 131 ? -24.48606 25.39707  -24.85940 1.000 34.57000  ? 249 TYR A CD1 1 
ATOM   725  C CD2 . TYR A 1 131 ? -24.68998 23.57387  -26.38251 1.000 30.75000  ? 249 TYR A CD2 1 
ATOM   726  C CE1 . TYR A 1 131 ? -23.79921 26.14292  -25.80184 1.000 34.26000  ? 249 TYR A CE1 1 
ATOM   727  C CE2 . TYR A 1 131 ? -23.99412 24.31475  -27.34595 1.000 34.61000  ? 249 TYR A CE2 1 
ATOM   728  C CZ  . TYR A 1 131 ? -23.55475 25.61476  -27.04110 1.000 40.89000  ? 249 TYR A CZ  1 
ATOM   729  O OH  . TYR A 1 131 ? -22.87393 26.41359  -27.95051 1.000 43.57000  ? 249 TYR A OH  1 
ATOM   730  N N   . MET A 1 132 ? -28.34666 22.50978  -25.55281 1.000 41.93000  ? 250 MET A N   1 
ATOM   731  C CA  . MET A 1 132 ? -29.09335 22.30719  -26.79407 1.000 37.32000  ? 250 MET A CA  1 
ATOM   732  C C   . MET A 1 132 ? -30.41968 23.07661  -26.79986 1.000 39.96000  ? 250 MET A C   1 
ATOM   733  O O   . MET A 1 132 ? -30.74081 23.77004  -27.77652 1.000 33.83000  ? 250 MET A O   1 
ATOM   734  C CB  . MET A 1 132 ? -29.33866 20.82319  -26.97799 1.000 33.02000  ? 250 MET A CB  1 
ATOM   735  C CG  . MET A 1 132 ? -28.13422 20.03502  -27.50823 1.000 42.34000  ? 250 MET A CG  1 
ATOM   736  S SD  . MET A 1 132 ? -27.31329 20.81222  -28.93362 1.000 37.28000  ? 250 MET A SD  1 
ATOM   737  C CE  . MET A 1 132 ? -28.11566 19.94266  -30.28128 1.000 34.52000  ? 250 MET A CE  1 
ATOM   738  N N   . PHE A 1 133 ? -31.20983 22.95362  -25.71508 1.000 38.63000  ? 251 PHE A N   1 
ATOM   739  C CA  . PHE A 1 133 ? -32.50115 23.64300  -25.61991 1.000 36.91000  ? 251 PHE A CA  1 
ATOM   740  C C   . PHE A 1 133 ? -32.34180 25.16513  -25.71199 1.000 39.49000  ? 251 PHE A C   1 
ATOM   741  O O   . PHE A 1 133 ? -33.14197 25.84316  -26.36974 1.000 33.86000  ? 251 PHE A O   1 
ATOM   742  C CB  . PHE A 1 133 ? -33.19823 23.27393  -24.30926 1.000 38.69000  ? 251 PHE A CB  1 
ATOM   743  C CG  . PHE A 1 133 ? -33.45961 21.78871  -24.13818 1.000 40.99000  ? 251 PHE A CG  1 
ATOM   744  C CD1 . PHE A 1 133 ? -33.86907 21.00416  -25.21072 1.000 37.50000  ? 251 PHE A CD1 1 
ATOM   745  C CD2 . PHE A 1 133 ? -33.28857 21.17906  -22.89451 1.000 40.43000  ? 251 PHE A CD2 1 
ATOM   746  C CE1 . PHE A 1 133 ? -34.09150 19.63797  -25.05256 1.000 39.99000  ? 251 PHE A CE1 1 
ATOM   747  C CE2 . PHE A 1 133 ? -33.51800 19.79685  -22.71736 1.000 44.83000  ? 251 PHE A CE2 1 
ATOM   748  C CZ  . PHE A 1 133 ? -33.91747 19.03031  -23.79289 1.000 41.59000  ? 251 PHE A CZ  1 
ATOM   749  N N   . LYS A 1 134 ? -31.32917 25.72818  -25.04447 1.000 36.17000  ? 252 LYS A N   1 
ATOM   750  C CA  . LYS A 1 134 ? -31.10978 27.16635  -25.16559 1.000 38.59000  ? 252 LYS A CA  1 
ATOM   751  C C   . LYS A 1 134 ? -30.96768 27.55827  -26.63133 1.000 38.08000  ? 252 LYS A C   1 
ATOM   752  O O   . LYS A 1 134 ? -31.49705 28.58929  -27.06382 1.000 42.44000  ? 252 LYS A O   1 
ATOM   753  C CB  . LYS A 1 134 ? -29.87812 27.60041  -24.35410 1.000 34.99000  ? 252 LYS A CB  1 
ATOM   754  C CG  . LYS A 1 134 ? -30.10140 27.60842  -22.83214 1.000 41.02000  ? 252 LYS A CG  1 
ATOM   755  C CD  . LYS A 1 134 ? -29.20598 28.62038  -22.10238 1.000 41.39000  ? 252 LYS A CD  1 
ATOM   756  N N   . GLY A 1 135 ? -30.28117 26.73003  -27.42069 1.000 37.74000  ? 253 GLY A N   1 
ATOM   757  C CA  . GLY A 1 135 ? -30.17203 27.01092  -28.84351 1.000 31.58000  ? 253 GLY A CA  1 
ATOM   758  C C   . GLY A 1 135 ? -31.50183 26.85375  -29.55484 1.000 40.37000  ? 253 GLY A C   1 
ATOM   759  O O   . GLY A 1 135 ? -31.83201 27.64513  -30.44444 1.000 39.23000  ? 253 GLY A O   1 
ATOM   760  N N   . ILE A 1 136 ? -32.28845 25.83818  -29.16759 1.000 36.56000  ? 254 ILE A N   1 
ATOM   761  C CA  . ILE A 1 136 ? -33.61927 25.65393  -29.74194 1.000 32.45000  ? 254 ILE A CA  1 
ATOM   762  C C   . ILE A 1 136 ? -34.50085 26.86037  -29.44239 1.000 37.86000  ? 254 ILE A C   1 
ATOM   763  O O   . ILE A 1 136 ? -35.21791 27.36057  -30.31523 1.000 43.91000  ? 254 ILE A O   1 
ATOM   764  C CB  . ILE A 1 136 ? -34.26580 24.36834  -29.20782 1.000 38.30000  ? 254 ILE A CB  1 
ATOM   765  C CG1 . ILE A 1 136 ? -33.47518 23.14494  -29.65339 1.000 35.38000  ? 254 ILE A CG1 1 
ATOM   766  C CG2 . ILE A 1 136 ? -35.72369 24.30195  -29.64312 1.000 30.38000  ? 254 ILE A CG2 1 
ATOM   767  C CD1 . ILE A 1 136 ? -33.07996 23.21994  -31.04827 1.000 39.49000  ? 254 ILE A CD1 1 
ATOM   768  N N   . ILE A 1 137 ? -34.48129 27.33165  -28.20211 1.000 34.54000  ? 255 ILE A N   1 
ATOM   769  C CA  . ILE A 1 137 ? -35.28186 28.50010  -27.85358 1.000 38.01000  ? 255 ILE A CA  1 
ATOM   770  C C   . ILE A 1 137 ? -34.86223 29.69978  -28.69879 1.000 44.71000  ? 255 ILE A C   1 
ATOM   771  O O   . ILE A 1 137 ? -35.70543 30.39375  -29.28754 1.000 44.16000  ? 255 ILE A O   1 
ATOM   772  C CB  . ILE A 1 137 ? -35.16527 28.79427  -26.35038 1.000 37.79000  ? 255 ILE A CB  1 
ATOM   773  C CG1 . ILE A 1 137 ? -35.79592 27.64051  -25.53717 1.000 34.43000  ? 255 ILE A CG1 1 
ATOM   774  C CG2 . ILE A 1 137 ? -35.82790 30.09780  -26.05674 1.000 36.19000  ? 255 ILE A CG2 1 
ATOM   775  C CD1 . ILE A 1 137 ? -35.36616 27.57684  -24.07513 1.000 30.41000  ? 255 ILE A CD1 1 
ATOM   776  N N   . SER A 1 138 ? -33.54333 29.94941  -28.78440 1.000 39.63000  ? 256 SER A N   1 
ATOM   777  C CA  . SER A 1 138 ? -33.03063 31.01214  -29.65068 1.000 41.14000  ? 256 SER A CA  1 
ATOM   778  C C   . SER A 1 138 ? -33.43627 30.78781  -31.09689 1.000 40.91000  ? 256 SER A C   1 
ATOM   779  O O   . SER A 1 138 ? -33.61455 31.74518  -31.85436 1.000 44.66000  ? 256 SER A O   1 
ATOM   780  C CB  . SER A 1 138 ? -31.49969 31.10076  -29.56435 1.000 35.52000  ? 256 SER A CB  1 
ATOM   781  O OG  . SER A 1 138 ? -31.04500 31.25217  -28.22218 1.000 41.00000  ? 256 SER A OG  1 
ATOM   782  N N   . PHE A 1 139 ? -33.55764 29.53100  -31.50165 1.000 37.80000  ? 257 PHE A N   1 
ATOM   783  C CA  . PHE A 1 139 ? -33.97826 29.22561  -32.85891 1.000 39.06000  ? 257 PHE A CA  1 
ATOM   784  C C   . PHE A 1 139 ? -35.39442 29.70813  -33.09989 1.000 41.21000  ? 257 PHE A C   1 
ATOM   785  O O   . PHE A 1 139 ? -35.68852 30.34660  -34.11557 1.000 43.31000  ? 257 PHE A O   1 
ATOM   786  C CB  . PHE A 1 139 ? -33.89455 27.71479  -33.09778 1.000 38.34000  ? 257 PHE A CB  1 
ATOM   787  C CG  . PHE A 1 139 ? -34.59213 27.26921  -34.34017 1.000 36.70000  ? 257 PHE A CG  1 
ATOM   788  C CD1 . PHE A 1 139 ? -34.02300 27.50619  -35.59293 1.000 35.76000  ? 257 PHE A CD1 1 
ATOM   789  C CD2 . PHE A 1 139 ? -35.80585 26.60964  -34.26978 1.000 35.07000  ? 257 PHE A CD2 1 
ATOM   790  C CE1 . PHE A 1 139 ? -34.65560 27.09260  -36.75329 1.000 35.79000  ? 257 PHE A CE1 1 
ATOM   791  C CE2 . PHE A 1 139 ? -36.45846 26.20303  -35.42614 1.000 30.25000  ? 257 PHE A CE2 1 
ATOM   792  C CZ  . PHE A 1 139 ? -35.88133 26.44601  -36.66589 1.000 34.54000  ? 257 PHE A CZ  1 
ATOM   793  N N   . ALA A 1 140 ? -36.29246 29.40219  -32.17223 1.000 40.04000  ? 258 ALA A N   1 
ATOM   794  C CA  . ALA A 1 140 ? -37.68856 29.72471  -32.39730 1.000 40.09000  ? 258 ALA A CA  1 
ATOM   795  C C   . ALA A 1 140 ? -37.90622 31.24265  -32.45045 1.000 45.29000  ? 258 ALA A C   1 
ATOM   796  O O   . ALA A 1 140 ? -38.63927 31.73284  -33.31930 1.000 42.37000  ? 258 ALA A O   1 
ATOM   797  C CB  . ALA A 1 140 ? -38.53046 29.04371  -31.31986 1.000 33.12000  ? 258 ALA A CB  1 
ATOM   798  N N   . LYS A 1 141 ? -37.21671 32.00344  -31.57888 1.000 44.19000  ? 259 LYS A N   1 
ATOM   799  C CA  . LYS A 1 141 ? -37.41937 33.45528  -31.46106 1.000 45.59000  ? 259 LYS A CA  1 
ATOM   800  C C   . LYS A 1 141 ? -36.99748 34.23719  -32.69952 1.000 45.32000  ? 259 LYS A C   1 
ATOM   801  O O   . LYS A 1 141 ? -37.49293 35.34410  -32.91696 1.000 50.95000  ? 259 LYS A O   1 
ATOM   802  C CB  . LYS A 1 141 ? -36.62983 34.01294  -30.28959 1.000 50.28000  ? 259 LYS A CB  1 
ATOM   803  C CG  . LYS A 1 141 ? -37.09192 33.63693  -28.92489 1.000 50.48000  ? 259 LYS A CG  1 
ATOM   804  C CD  . LYS A 1 141 ? -35.99228 34.05585  -27.96544 1.000 58.97000  ? 259 LYS A CD  1 
ATOM   805  C CE  . LYS A 1 141 ? -35.80494 35.56095  -27.98252 1.000 61.23000  ? 259 LYS A CE  1 
ATOM   806  N NZ  . LYS A 1 141 ? -35.26438 36.02542  -26.67615 1.000 74.85000  ? 259 LYS A NZ  1 
ATOM   807  N N   . VAL A 1 142 ? -36.03212 33.73307  -33.46964 1.000 44.93000  ? 260 VAL A N   1 
ATOM   808  C CA  . VAL A 1 142 ? -35.67816 34.35697  -34.74421 1.000 46.94000  ? 260 VAL A CA  1 
ATOM   809  C C   . VAL A 1 142 ? -36.82696 34.32006  -35.74644 1.000 43.66000  ? 260 VAL A C   1 
ATOM   810  O O   . VAL A 1 142 ? -36.87214 35.13658  -36.67497 1.000 50.45000  ? 260 VAL A O   1 
ATOM   811  C CB  . VAL A 1 142 ? -34.42774 33.65786  -35.33039 1.000 48.19000  ? 260 VAL A CB  1 
ATOM   812  C CG1 . VAL A 1 142 ? -34.05074 34.23384  -36.70998 1.000 56.30000  ? 260 VAL A CG1 1 
ATOM   813  C CG2 . VAL A 1 142 ? -33.24798 33.80182  -34.37809 1.000 38.55000  ? 260 VAL A CG2 1 
ATOM   814  N N   . ILE A 1 143 ? -37.75157 33.38256  -35.59216 1.000 43.95000  ? 261 ILE A N   1 
ATOM   815  C CA  . ILE A 1 143 ? -38.74326 33.09173  -36.61952 1.000 46.77000  ? 261 ILE A CA  1 
ATOM   816  C C   . ILE A 1 143 ? -39.95069 33.99107  -36.40121 1.000 48.04000  ? 261 ILE A C   1 
ATOM   817  O O   . ILE A 1 143 ? -40.59186 33.94317  -35.34436 1.000 49.54000  ? 261 ILE A O   1 
ATOM   818  C CB  . ILE A 1 143 ? -39.12661 31.60356  -36.60946 1.000 43.40000  ? 261 ILE A CB  1 
ATOM   819  C CG1 . ILE A 1 143 ? -37.87319 30.74023  -36.82074 1.000 42.36000  ? 261 ILE A CG1 1 
ATOM   820  C CG2 . ILE A 1 143 ? -40.14427 31.29375  -37.69283 1.000 44.51000  ? 261 ILE A CG2 1 
ATOM   821  C CD1 . ILE A 1 143 ? -38.09557 29.24100  -36.60566 1.000 41.25000  ? 261 ILE A CD1 1 
ATOM   822  N N   . SER A 1 144 ? -40.24387 34.83153  -37.39577 1.000 47.10000  ? 262 SER A N   1 
ATOM   823  C CA  . SER A 1 144 ? -41.32333 35.80798  -37.26640 1.000 52.55000  ? 262 SER A CA  1 
ATOM   824  C C   . SER A 1 144 ? -42.63511 35.14916  -36.85303 1.000 51.91000  ? 262 SER A C   1 
ATOM   825  O O   . SER A 1 144 ? -43.27348 35.57431  -35.88490 1.000 48.80000  ? 262 SER A O   1 
ATOM   826  C CB  . SER A 1 144 ? -41.48940 36.54068  -38.58300 1.000 45.61000  ? 262 SER A CB  1 
ATOM   827  O OG  . SER A 1 144 ? -41.45879 35.58831  -39.62855 1.000 52.53000  ? 262 SER A OG  1 
ATOM   828  N N   . TYR A 1 145 ? -43.03051 34.08041  -37.56373 1.000 49.73000  ? 263 TYR A N   1 
ATOM   829  C CA  . TYR A 1 145 ? -44.30327 33.41069  -37.28936 1.000 48.51000  ? 263 TYR A CA  1 
ATOM   830  C C   . TYR A 1 145 ? -44.38933 32.93080  -35.84966 1.000 44.86000  ? 263 TYR A C   1 
ATOM   831  O O   . TYR A 1 145 ? -45.46545 32.94398  -35.24385 1.000 51.40000  ? 263 TYR A O   1 
ATOM   832  C CB  . TYR A 1 145 ? -44.49758 32.22615  -38.23009 1.000 46.95000  ? 263 TYR A CB  1 
ATOM   833  C CG  . TYR A 1 145 ? -44.18743 32.50114  -39.68087 1.000 46.69000  ? 263 TYR A CG  1 
ATOM   834  C CD1 . TYR A 1 145 ? -45.16649 32.99922  -40.54176 1.000 41.29000  ? 263 TYR A CD1 1 
ATOM   835  C CD2 . TYR A 1 145 ? -42.91623 32.25700  -40.19378 1.000 48.65000  ? 263 TYR A CD2 1 
ATOM   836  C CE1 . TYR A 1 145 ? -44.87935 33.23913  -41.87657 1.000 51.80000  ? 263 TYR A CE1 1 
ATOM   837  C CE2 . TYR A 1 145 ? -42.61509 32.50191  -41.52358 1.000 51.78000  ? 263 TYR A CE2 1 
ATOM   838  C CZ  . TYR A 1 145 ? -43.60315 32.98497  -42.36248 1.000 56.02000  ? 263 TYR A CZ  1 
ATOM   839  O OH  . TYR A 1 145 ? -43.30900 33.21688  -43.68829 1.000 61.61000  ? 263 TYR A OH  1 
ATOM   840  N N   . PHE A 1 146 ? -43.27223 32.47997  -35.29271 1.000 46.18000  ? 264 PHE A N   1 
ATOM   841  C CA  . PHE A 1 146 ? -43.28130 32.03615  -33.90498 1.000 47.97000  ? 264 PHE A CA  1 
ATOM   842  C C   . PHE A 1 146 ? -43.33399 33.22657  -32.96329 1.000 48.87000  ? 264 PHE A C   1 
ATOM   843  O O   . PHE A 1 146 ? -44.04117 33.20466  -31.94643 1.000 48.32000  ? 264 PHE A O   1 
ATOM   844  C CB  . PHE A 1 146 ? -42.04297 31.18552  -33.62525 1.000 41.22000  ? 264 PHE A CB  1 
ATOM   845  C CG  . PHE A 1 146 ? -41.95603 30.71574  -32.22451 1.000 39.14000  ? 264 PHE A CG  1 
ATOM   846  C CD1 . PHE A 1 146 ? -42.61860 29.57222  -31.83030 1.000 40.89000  ? 264 PHE A CD1 1 
ATOM   847  C CD2 . PHE A 1 146 ? -41.24852 31.44150  -31.28795 1.000 35.90000  ? 264 PHE A CD2 1 
ATOM   848  C CE1 . PHE A 1 146 ? -42.55865 29.13947  -30.52154 1.000 41.51000  ? 264 PHE A CE1 1 
ATOM   849  C CE2 . PHE A 1 146 ? -41.19358 31.03176  -29.99218 1.000 40.03000  ? 264 PHE A CE2 1 
ATOM   850  C CZ  . PHE A 1 146 ? -41.84414 29.86325  -29.60299 1.000 40.30000  ? 264 PHE A CZ  1 
ATOM   851  N N   . ARG A 1 147 ? -42.58339 34.27010  -33.30354 1.000 54.19000  ? 265 ARG A N   1 
ATOM   852  C CA  . ARG A 1 147 ? -42.46306 35.47167  -32.48981 1.000 52.84000  ? 265 ARG A CA  1 
ATOM   853  C C   . ARG A 1 147 ? -43.79240 36.21806  -32.42761 1.000 54.52000  ? 265 ARG A C   1 
ATOM   854  O O   . ARG A 1 147 ? -44.15183 36.76028  -31.37536 1.000 59.13000  ? 265 ARG A O   1 
ATOM   855  C CB  . ARG A 1 147 ? -41.31131 36.29454  -33.09711 1.000 55.59000  ? 265 ARG A CB  1 
ATOM   856  C CG  . ARG A 1 147 ? -40.71297 37.48235  -32.33730 1.000 69.49000  ? 265 ARG A CG  1 
ATOM   857  C CD  . ARG A 1 147 ? -39.46004 37.96236  -33.12179 1.000 56.76000  ? 265 ARG A CD  1 
ATOM   858  N NE  . ARG A 1 147 ? -39.79892 38.28703  -34.50666 1.000 60.73000  ? 265 ARG A NE  1 
ATOM   859  C CZ  . ARG A 1 147 ? -38.92290 38.62996  -35.44830 1.000 66.99000  ? 265 ARG A CZ  1 
ATOM   860  N NH1 . ARG A 1 147 ? -39.34180 38.91850  -36.68021 1.000 68.10000  ? 265 ARG A NH1 1 
ATOM   861  N NH2 . ARG A 1 147 ? -37.62295 38.63738  -35.18005 1.000 80.90000  ? 265 ARG A NH2 1 
ATOM   862  N N   . ASP A 1 148 ? -44.56219 36.19336  -33.52177 1.000 51.15000  ? 266 ASP A N   1 
ATOM   863  C CA  . ASP A 1 148 ? -45.88545 36.80482  -33.58266 1.000 54.02000  ? 266 ASP A CA  1 
ATOM   864  C C   . ASP A 1 148 ? -46.93828 36.08086  -32.74728 1.000 58.78000  ? 266 ASP A C   1 
ATOM   865  O O   . ASP A 1 148 ? -48.04455 36.61329  -32.59117 1.000 61.08000  ? 266 ASP A O   1 
ATOM   866  C CB  . ASP A 1 148 ? -46.36521 36.87046  -35.03271 1.000 48.57000  ? 266 ASP A CB  1 
ATOM   867  C CG  . ASP A 1 148 ? -45.56548 37.85330  -35.86298 1.000 61.57000  ? 266 ASP A CG  1 
ATOM   868  O OD1 . ASP A 1 148 ? -45.05902 38.84018  -35.28231 1.000 58.38000  ? 266 ASP A OD1 1 
ATOM   869  O OD2 . ASP A 1 148 ? -45.46617 37.65507  -37.09808 1.000 74.05000  ? 266 ASP A OD2 1 
ATOM   870  N N   . LEU A 1 149 ? -46.64086 34.88669  -32.22692 1.000 53.69000  ? 267 LEU A N   1 
ATOM   871  C CA  . LEU A 1 149 ? -47.58768 34.14979  -31.40653 1.000 52.70000  ? 267 LEU A CA  1 
ATOM   872  C C   . LEU A 1 149 ? -47.58419 34.70496  -29.98120 1.000 51.58000  ? 267 LEU A C   1 
ATOM   873  O O   . LEU A 1 149 ? -46.60454 35.31813  -29.54966 1.000 51.49000  ? 267 LEU A O   1 
ATOM   874  C CB  . LEU A 1 149 ? -47.23104 32.66193  -31.38534 1.000 50.19000  ? 267 LEU A CB  1 
ATOM   875  C CG  . LEU A 1 149 ? -47.45343 31.80958  -32.64288 1.000 51.23000  ? 267 LEU A CG  1 
ATOM   876  C CD1 . LEU A 1 149 ? -46.96785 30.38165  -32.41363 1.000 46.24000  ? 267 LEU A CD1 1 
ATOM   877  C CD2 . LEU A 1 149 ? -48.90434 31.77820  -33.08017 1.000 42.28000  ? 267 LEU A CD2 1 
ATOM   878  N N   . PRO A 1 150 ? -48.68125 34.53004  -29.24551 1.000 51.50000  ? 268 PRO A N   1 
ATOM   879  C CA  . PRO A 1 150 ? -48.70770 34.96421  -27.84026 1.000 49.41000  ? 268 PRO A CA  1 
ATOM   880  C C   . PRO A 1 150 ? -47.67653 34.22216  -27.00050 1.000 54.14000  ? 268 PRO A C   1 
ATOM   881  O O   . PRO A 1 150 ? -47.46697 33.02036  -27.17217 1.000 59.07000  ? 268 PRO A O   1 
ATOM   882  C CB  . PRO A 1 150 ? -50.13563 34.61932  -27.39972 1.000 50.73000  ? 268 PRO A CB  1 
ATOM   883  C CG  . PRO A 1 150 ? -50.93046 34.75071  -28.64679 1.000 51.53000  ? 268 PRO A CG  1 
ATOM   884  C CD  . PRO A 1 150 ? -50.02901 34.18674  -29.73196 1.000 55.93000  ? 268 PRO A CD  1 
ATOM   885  N N   . ILE A 1 151 ? -47.06002 34.94788  -26.06196 1.000 54.55000  ? 269 ILE A N   1 
ATOM   886  C CA  . ILE A 1 151 ? -46.02095 34.41282  -25.17808 1.000 58.37000  ? 269 ILE A CA  1 
ATOM   887  C C   . ILE A 1 151 ? -46.41146 33.05431  -24.60795 1.000 56.66000  ? 269 ILE A C   1 
ATOM   888  O O   . ILE A 1 151 ? -45.59306 32.12366  -24.59335 1.000 56.47000  ? 269 ILE A O   1 
ATOM   889  C CB  . ILE A 1 151 ? -45.67859 35.39130  -24.03045 1.000 60.18000  ? 269 ILE A CB  1 
ATOM   890  C CG1 . ILE A 1 151 ? -45.37611 36.80074  -24.56056 1.000 69.37000  ? 269 ILE A CG1 1 
ATOM   891  C CG2 . ILE A 1 151 ? -44.48652 34.88635  -23.23352 1.000 55.58000  ? 269 ILE A CG2 1 
ATOM   892  C CD1 . ILE A 1 151 ? -44.02303 36.92076  -25.28124 1.000 66.10000  ? 269 ILE A CD1 1 
ATOM   893  N N   . GLU A 1 152 ? -47.65749 32.91849  -24.14326 1.000 58.87000  ? 270 GLU A N   1 
ATOM   894  C CA  . GLU A 1 152 ? -48.05405 31.65795  -23.51408 1.000 60.06000  ? 270 GLU A CA  1 
ATOM   895  C C   . GLU A 1 152 ? -48.07337 30.52454  -24.52675 1.000 55.47000  ? 270 GLU A C   1 
ATOM   896  O O   . GLU A 1 152 ? -47.80293 29.36745  -24.17738 1.000 51.01000  ? 270 GLU A O   1 
ATOM   897  C CB  . GLU A 1 152 ? -49.42024 31.79495  -22.83225 1.000 52.41000  ? 270 GLU A CB  1 
ATOM   898  C CG  . GLU A 1 152 ? -49.33967 32.16212  -21.35802 1.000 68.93000  ? 270 GLU A CG  1 
ATOM   899  N N   . ASP A 1 153 ? -48.37427 30.83414  -25.78462 1.000 51.86000  ? 271 ASP A N   1 
ATOM   900  C CA  . ASP A 1 153 ? -48.38062 29.77873  -26.78224 1.000 55.56000  ? 271 ASP A CA  1 
ATOM   901  C C   . ASP A 1 153 ? -46.95541 29.46961  -27.22716 1.000 51.37000  ? 271 ASP A C   1 
ATOM   902  O O   . ASP A 1 153 ? -46.59786 28.29988  -27.41578 1.000 47.97000  ? 271 ASP A O   1 
ATOM   903  C CB  . ASP A 1 153 ? -49.28258 30.17702  -27.96018 1.000 56.54000  ? 271 ASP A CB  1 
ATOM   904  C CG  . ASP A 1 153 ? -50.74341 29.70328  -27.78272 1.000 58.04000  ? 271 ASP A CG  1 
ATOM   905  O OD1 . ASP A 1 153 ? -51.13943 29.28245  -26.66704 1.000 65.22000  ? 271 ASP A OD1 1 
ATOM   906  O OD2 . ASP A 1 153 ? -51.49324 29.74253  -28.77284 1.000 57.78000  ? 271 ASP A OD2 1 
ATOM   907  N N   . GLN A 1 154 ? -46.11784 30.50804  -27.33640 1.000 45.49000  ? 272 GLN A N   1 
ATOM   908  C CA  . GLN A 1 154 ? -44.69071 30.30680  -27.56425 1.000 44.41000  ? 272 GLN A CA  1 
ATOM   909  C C   . GLN A 1 154 ? -44.07451 29.39545  -26.50367 1.000 50.35000  ? 272 GLN A C   1 
ATOM   910  O O   . GLN A 1 154 ? -43.20509 28.56901  -26.80800 1.000 48.47000  ? 272 GLN A O   1 
ATOM   911  C CB  . GLN A 1 154 ? -43.97830 31.64511  -27.55633 1.000 47.20000  ? 272 GLN A CB  1 
ATOM   912  C CG  . GLN A 1 154 ? -44.24645 32.50170  -28.75388 1.000 48.72000  ? 272 GLN A CG  1 
ATOM   913  C CD  . GLN A 1 154 ? -43.58107 33.83289  -28.58798 1.000 52.86000  ? 272 GLN A CD  1 
ATOM   914  O OE1 . GLN A 1 154 ? -42.44618 33.89812  -28.12673 1.000 58.32000  ? 272 GLN A OE1 1 
ATOM   915  N NE2 . GLN A 1 154 ? -44.29448 34.90776  -28.89548 1.000 56.52000  ? 272 GLN A NE2 1 
ATOM   916  N N   . ILE A 1 155 ? -44.49181 29.54953  -25.24766 1.000 47.89000  ? 273 ILE A N   1 
ATOM   917  C CA  . ILE A 1 155 ? -44.00361 28.66313  -24.20109 1.000 42.46000  ? 273 ILE A CA  1 
ATOM   918  C C   . ILE A 1 155 ? -44.47994 27.24307  -24.45401 1.000 45.74000  ? 273 ILE A C   1 
ATOM   919  O O   . ILE A 1 155 ? -43.68453 26.29742  -24.46742 1.000 46.89000  ? 273 ILE A O   1 
ATOM   920  C CB  . ILE A 1 155 ? -44.44709 29.17212  -22.81887 1.000 43.23000  ? 273 ILE A CB  1 
ATOM   921  C CG1 . ILE A 1 155 ? -43.72473 30.47924  -22.47697 1.000 46.37000  ? 273 ILE A CG1 1 
ATOM   922  C CG2 . ILE A 1 155 ? -44.21683 28.12060  -21.75545 1.000 39.14000  ? 273 ILE A CG2 1 
ATOM   923  C CD1 . ILE A 1 155 ? -44.06621 31.00930  -21.13472 1.000 43.42000  ? 273 ILE A CD1 1 
ATOM   924  N N   . SER A 1 156 ? -45.78683 27.07762  -24.66235 1.000 44.97000  ? 274 SER A N   1 
ATOM   925  C CA  . SER A 1 156 ? -46.36222 25.74746  -24.82524 1.000 48.66000  ? 274 SER A CA  1 
ATOM   926  C C   . SER A 1 156 ? -45.72468 25.01043  -25.99655 1.000 45.57000  ? 274 SER A C   1 
ATOM   927  O O   . SER A 1 156 ? -45.46516 23.79850  -25.92022 1.000 36.61000  ? 274 SER A O   1 
ATOM   928  C CB  . SER A 1 156 ? -47.87624 25.86791  -25.02545 1.000 55.86000  ? 274 SER A CB  1 
ATOM   929  O OG  . SER A 1 156 ? -48.52361 26.20292  -23.80837 1.000 61.18000  ? 274 SER A OG  1 
ATOM   930  N N   . LEU A 1 157 ? -45.46480 25.73418  -27.08708 1.000 36.83000  ? 275 LEU A N   1 
ATOM   931  C CA  . LEU A 1 157 ? -44.83131 25.12314  -28.24432 1.000 34.78000  ? 275 LEU A CA  1 
ATOM   932  C C   . LEU A 1 157 ? -43.42117 24.66056  -27.90833 1.000 40.73000  ? 275 LEU A C   1 
ATOM   933  O O   . LEU A 1 157 ? -43.00562 23.56397  -28.30190 1.000 37.03000  ? 275 LEU A O   1 
ATOM   934  C CB  . LEU A 1 157 ? -44.81654 26.11782  -29.39474 1.000 39.69000  ? 275 LEU A CB  1 
ATOM   935  C CG  . LEU A 1 157 ? -46.16258 26.47260  -30.02078 1.000 38.21000  ? 275 LEU A CG  1 
ATOM   936  C CD1 . LEU A 1 157 ? -45.88370 27.27345  -31.25325 1.000 40.94000  ? 275 LEU A CD1 1 
ATOM   937  C CD2 . LEU A 1 157 ? -46.98997 25.23144  -30.35966 1.000 39.03000  ? 275 LEU A CD2 1 
ATOM   938  N N   . LEU A 1 158 ? -42.68067 25.46944  -27.14572 1.000 39.25000  ? 276 LEU A N   1 
ATOM   939  C CA  . LEU A 1 158 ? -41.34456 25.06379  -26.74671 1.000 36.65000  ? 276 LEU A CA  1 
ATOM   940  C C   . LEU A 1 158 ? -41.39221 23.86021  -25.80643 1.000 44.62000  ? 276 LEU A C   1 
ATOM   941  O O   . LEU A 1 158 ? -40.64575 22.89166  -26.00086 1.000 47.36000  ? 276 LEU A O   1 
ATOM   942  C CB  . LEU A 1 158 ? -40.61520 26.25775  -26.13488 1.000 43.18000  ? 276 LEU A CB  1 
ATOM   943  C CG  . LEU A 1 158 ? -40.06641 27.20663  -27.22722 1.000 40.52000  ? 276 LEU A CG  1 
ATOM   944  C CD1 . LEU A 1 158 ? -39.64010 28.52748  -26.65036 1.000 41.65000  ? 276 LEU A CD1 1 
ATOM   945  C CD2 . LEU A 1 158 ? -38.91800 26.59060  -28.02337 1.000 37.73000  ? 276 LEU A CD2 1 
ATOM   946  N N   . LYS A 1 159 ? -42.28939 23.86024  -24.81559 1.000 39.10000  ? 277 LYS A N   1 
ATOM   947  C CA  . LYS A 1 159 ? -42.38004 22.69168  -23.93930 1.000 37.66000  ? 277 LYS A CA  1 
ATOM   948  C C   . LYS A 1 159 ? -42.70534 21.40600  -24.72111 1.000 41.95000  ? 277 LYS A C   1 
ATOM   949  O O   . LYS A 1 159 ? -42.25492 20.30799  -24.36768 1.000 35.70000  ? 277 LYS A O   1 
ATOM   950  C CB  . LYS A 1 159 ? -43.44234 22.92259  -22.87336 1.000 40.13000  ? 277 LYS A CB  1 
ATOM   951  C CG  . LYS A 1 159 ? -43.16297 23.88406  -21.76074 1.000 48.49000  ? 277 LYS A CG  1 
ATOM   952  C CD  . LYS A 1 159 ? -44.48019 24.03398  -20.90290 1.000 45.48000  ? 277 LYS A CD  1 
ATOM   953  C CE  . LYS A 1 159 ? -44.94578 22.75931  -20.11673 1.000 56.45000  ? 277 LYS A CE  1 
ATOM   954  N NZ  . LYS A 1 159 ? -44.19878 22.26796  -18.95588 1.000 62.05000  ? 277 LYS A NZ  1 
ATOM   955  N N   . GLY A 1 160 ? -43.50118 21.49927  -25.77721 1.000 40.93000  ? 278 GLY A N   1 
ATOM   956  C CA  . GLY A 1 160 ? -43.80751 20.26055  -26.48299 1.000 34.01000  ? 278 GLY A CA  1 
ATOM   957  C C   . GLY A 1 160 ? -42.80511 19.79160  -27.51908 1.000 40.97000  ? 278 GLY A C   1 
ATOM   958  O O   . GLY A 1 160 ? -42.76653 18.60582  -27.86577 1.000 36.54000  ? 278 GLY A O   1 
ATOM   959  N N   . ALA A 1 161 ? -42.01142 20.71925  -28.03639 1.000 38.75000  ? 279 ALA A N   1 
ATOM   960  C CA  . ALA A 1 161 ? -41.09609 20.41328  -29.10740 1.000 35.08000  ? 279 ALA A CA  1 
ATOM   961  C C   . ALA A 1 161 ? -39.62814 20.34769  -28.70417 1.000 38.98000  ? 279 ALA A C   1 
ATOM   962  O O   . ALA A 1 161 ? -38.81681 19.96754  -29.54524 1.000 40.49000  ? 279 ALA A O   1 
ATOM   963  C CB  . ALA A 1 161 ? -41.24534 21.45187  -30.22182 1.000 37.07000  ? 279 ALA A CB  1 
ATOM   964  N N   . ALA A 1 162 ? -39.25152 20.70613  -27.46789 1.000 45.03000  ? 280 ALA A N   1 
ATOM   965  C CA  . ALA A 1 162 ? -37.82565 20.87357  -27.14853 1.000 36.39000  ? 280 ALA A CA  1 
ATOM   966  C C   . ALA A 1 162 ? -37.02704 19.59206  -27.40213 1.000 34.53000  ? 280 ALA A C   1 
ATOM   967  O O   . ALA A 1 162 ? -35.99293 19.61291  -28.07693 1.000 39.02000  ? 280 ALA A O   1 
ATOM   968  C CB  . ALA A 1 162 ? -37.64612 21.33179  -25.69922 1.000 35.78000  ? 280 ALA A CB  1 
ATOM   969  N N   . PHE A 1 163 ? -37.47865 18.46855  -26.86187 1.000 40.21000  ? 281 PHE A N   1 
ATOM   970  C CA  . PHE A 1 163 ? -36.77506 17.20700  -27.09949 1.000 42.51000  ? 281 PHE A CA  1 
ATOM   971  C C   . PHE A 1 163 ? -36.70564 16.89590  -28.59166 1.000 43.47000  ? 281 PHE A C   1 
ATOM   972  O O   . PHE A 1 163 ? -35.65436 16.47767  -29.10471 1.000 40.26000  ? 281 PHE A O   1 
ATOM   973  C CB  . PHE A 1 163 ? -37.47870 16.07624  -26.33628 1.000 37.59000  ? 281 PHE A CB  1 
ATOM   974  C CG  . PHE A 1 163 ? -36.91206 14.70663  -26.57798 1.000 41.28000  ? 281 PHE A CG  1 
ATOM   975  C CD1 . PHE A 1 163 ? -35.81399 14.25770  -25.87104 1.000 45.44000  ? 281 PHE A CD1 1 
ATOM   976  C CD2 . PHE A 1 163 ? -37.48951 13.85292  -27.50259 1.000 45.60000  ? 281 PHE A CD2 1 
ATOM   977  C CE1 . PHE A 1 163 ? -35.29539 12.98105  -26.08169 1.000 42.40000  ? 281 PHE A CE1 1 
ATOM   978  C CE2 . PHE A 1 163 ? -36.97491 12.56727  -27.72325 1.000 42.14000  ? 281 PHE A CE2 1 
ATOM   979  C CZ  . PHE A 1 163 ? -35.88085 12.13734  -27.01230 1.000 43.98000  ? 281 PHE A CZ  1 
ATOM   980  N N   . GLU A 1 164 ? -37.81061 17.12584  -29.30772 1.000 39.21000  ? 282 GLU A N   1 
ATOM   981  C CA  . GLU A 1 164 ? -37.86819 16.74664  -30.71096 1.000 32.23000  ? 282 GLU A CA  1 
ATOM   982  C C   . GLU A 1 164 ? -36.85537 17.52456  -31.53031 1.000 35.06000  ? 282 GLU A C   1 
ATOM   983  O O   . GLU A 1 164 ? -36.02899 16.93534  -32.23951 1.000 35.16000  ? 282 GLU A O   1 
ATOM   984  C CB  . GLU A 1 164 ? -39.28718 16.95033  -31.24110 1.000 35.25000  ? 282 GLU A CB  1 
ATOM   985  C CG  . GLU A 1 164 ? -40.30696 16.13143  -30.48077 1.000 36.84000  ? 282 GLU A CG  1 
ATOM   986  C CD  . GLU A 1 164 ? -41.71194 16.29712  -30.99493 1.000 38.84000  ? 282 GLU A CD  1 
ATOM   987  O OE1 . GLU A 1 164 ? -41.88993 16.77071  -32.13769 1.000 37.08000  ? 282 GLU A OE1 1 
ATOM   988  O OE2 . GLU A 1 164 ? -42.64492 15.93927  -30.25131 1.000 42.80000  ? 282 GLU A OE2 1 
ATOM   989  N N   . LEU A 1 165 ? -36.89898 18.85749  -31.44154 1.000 36.66000  ? 283 LEU A N   1 
ATOM   990  C CA  . LEU A 1 165 ? -35.93220 19.67634  -32.16088 1.000 32.55000  ? 283 LEU A CA  1 
ATOM   991  C C   . LEU A 1 165 ? -34.51216 19.39468  -31.68878 1.000 33.58000  ? 283 LEU A C   1 
ATOM   992  O O   . LEU A 1 165 ? -33.57304 19.44157  -32.48958 1.000 34.24000  ? 283 LEU A O   1 
ATOM   993  C CB  . LEU A 1 165 ? -36.31187 21.14109  -32.01409 1.000 31.62000  ? 283 LEU A CB  1 
ATOM   994  C CG  . LEU A 1 165 ? -37.40794 21.68215  -32.93297 1.000 37.72000  ? 283 LEU A CG  1 
ATOM   995  C CD1 . LEU A 1 165 ? -38.75271 21.04939  -32.65059 1.000 43.54000  ? 283 LEU A CD1 1 
ATOM   996  C CD2 . LEU A 1 165 ? -37.52566 23.18290  -32.60411 1.000 32.42000  ? 283 LEU A CD2 1 
ATOM   997  N N   . CYS A 1 166 ? -34.33025 19.05802  -30.41495 1.000 36.96000  ? 284 CYS A N   1 
ATOM   998  C CA  . CYS A 1 166 ? -32.98319 18.73434  -29.96489 1.000 37.15000  ? 284 CYS A CA  1 
ATOM   999  C C   . CYS A 1 166 ? -32.48851 17.47797  -30.66353 1.000 35.70000  ? 284 CYS A C   1 
ATOM   1000 O O   . CYS A 1 166 ? -31.36441 17.45177  -31.18334 1.000 33.09000  ? 284 CYS A O   1 
ATOM   1001 C CB  . CYS A 1 166 ? -32.93642 18.60446  -28.43596 1.000 36.92000  ? 284 CYS A CB  1 
ATOM   1002 S SG  . CYS A 1 166 ? -31.29735 18.16981  -27.79491 1.000 44.49000  ? 284 CYS A SG  1 
ATOM   1003 N N   . GLN A 1 167 ? -33.35505 16.46166  -30.77829 1.000 38.16000  ? 285 GLN A N   1 
ATOM   1004 C CA  . GLN A 1 167 ? -32.96038 15.19920  -31.40896 1.000 34.44000  ? 285 GLN A CA  1 
ATOM   1005 C C   . GLN A 1 167 ? -32.80015 15.31516  -32.92286 1.000 34.65000  ? 285 GLN A C   1 
ATOM   1006 O O   . GLN A 1 167 ? -31.94274 14.63287  -33.49611 1.000 38.44000  ? 285 GLN A O   1 
ATOM   1007 C CB  . GLN A 1 167 ? -33.97396 14.10756  -31.08379 1.000 34.63000  ? 285 GLN A CB  1 
ATOM   1008 C CG  . GLN A 1 167 ? -33.99906 13.71169  -29.62003 1.000 38.80000  ? 285 GLN A CG  1 
ATOM   1009 C CD  . GLN A 1 167 ? -32.63795 13.25200  -29.12304 1.000 40.69000  ? 285 GLN A CD  1 
ATOM   1010 O OE1 . GLN A 1 167 ? -31.85255 12.66578  -29.87224 1.000 43.95000  ? 285 GLN A OE1 1 
ATOM   1011 N NE2 . GLN A 1 167 ? -32.36329 13.49237  -27.85285 1.000 39.81000  ? 285 GLN A NE2 1 
ATOM   1012 N N   . LEU A 1 168 ? -33.61339 16.13920  -33.59353 1.000 32.53000  ? 286 LEU A N   1 
ATOM   1013 C CA  . LEU A 1 168 ? -33.37924 16.40513  -35.01533 1.000 37.55000  ? 286 LEU A CA  1 
ATOM   1014 C C   . LEU A 1 168 ? -32.02249 17.06786  -35.23069 1.000 34.84000  ? 286 LEU A C   1 
ATOM   1015 O O   . LEU A 1 168 ? -31.32318 16.77374  -36.20873 1.000 41.12000  ? 286 LEU A O   1 
ATOM   1016 C CB  . LEU A 1 168 ? -34.49752 17.27998  -35.58802 1.000 37.04000  ? 286 LEU A CB  1 
ATOM   1017 C CG  . LEU A 1 168 ? -35.87720 16.61645  -35.71867 1.000 31.78000  ? 286 LEU A CG  1 
ATOM   1018 C CD1 . LEU A 1 168 ? -36.91055 17.58725  -36.15029 1.000 30.74000  ? 286 LEU A CD1 1 
ATOM   1019 C CD2 . LEU A 1 168 ? -35.81651 15.44405  -36.68835 1.000 34.38000  ? 286 LEU A CD2 1 
ATOM   1020 N N   . ARG A 1 169 ? -31.61404 17.93749  -34.30610 1.000 37.07000  ? 287 ARG A N   1 
ATOM   1021 C CA  . ARG A 1 169 ? -30.31631 18.59414  -34.43648 1.000 32.28000  ? 287 ARG A CA  1 
ATOM   1022 C C   . ARG A 1 169 ? -29.17393 17.61949  -34.17784 1.000 39.11000  ? 287 ARG A C   1 
ATOM   1023 O O   . ARG A 1 169 ? -28.19378 17.60636  -34.93667 1.000 39.55000  ? 287 ARG A O   1 
ATOM   1024 C CB  . ARG A 1 169 ? -30.23500 19.79362  -33.49776 1.000 35.17000  ? 287 ARG A CB  1 
ATOM   1025 C CG  . ARG A 1 169 ? -30.66646 21.10681  -34.13207 1.000 33.21000  ? 287 ARG A CG  1 
ATOM   1026 C CD  . ARG A 1 169 ? -30.47217 22.34135  -33.21031 1.000 33.74000  ? 287 ARG A CD  1 
ATOM   1027 N NE  . ARG A 1 169 ? -30.88457 23.55159  -33.92567 1.000 31.93000  ? 287 ARG A NE  1 
ATOM   1028 C CZ  . ARG A 1 169 ? -30.68119 24.79945  -33.53390 1.000 30.60000  ? 287 ARG A CZ  1 
ATOM   1029 N NH1 . ARG A 1 169 ? -30.06352 25.05304  -32.38064 1.000 31.83000  ? 287 ARG A NH1 1 
ATOM   1030 N NH2 . ARG A 1 169 ? -31.10448 25.79472  -34.31039 1.000 25.73000  ? 287 ARG A NH2 1 
ATOM   1031 N N   . PHE A 1 170 ? -29.27676 16.79881  -33.11134 1.000 39.76000  ? 288 PHE A N   1 
ATOM   1032 C CA  . PHE A 1 170 ? -28.36330 15.66111  -32.93384 1.000 37.54000  ? 288 PHE A CA  1 
ATOM   1033 C C   . PHE A 1 170 ? -28.23769 14.79890  -34.18132 1.000 33.64000  ? 288 PHE A C   1 
ATOM   1034 O O   . PHE A 1 170 ? -27.12944 14.38059  -34.52737 1.000 36.54000  ? 288 PHE A O   1 
ATOM   1035 C CB  . PHE A 1 170 ? -28.77915 14.82222  -31.72241 1.000 33.46000  ? 288 PHE A CB  1 
ATOM   1036 C CG  . PHE A 1 170 ? -28.35865 15.39862  -30.38499 1.000 34.78000  ? 288 PHE A CG  1 
ATOM   1037 C CD1 . PHE A 1 170 ? -27.29105 16.28004  -30.30628 1.000 38.47000  ? 288 PHE A CD1 1 
ATOM   1038 C CD2 . PHE A 1 170 ? -29.09076 15.14262  -29.22928 1.000 43.09000  ? 288 PHE A CD2 1 
ATOM   1039 C CE1 . PHE A 1 170 ? -26.86751 16.79951  -29.09889 1.000 37.03000  ? 288 PHE A CE1 1 
ATOM   1040 C CE2 . PHE A 1 170 ? -28.70323 15.70607  -28.01388 1.000 48.06000  ? 288 PHE A CE2 1 
ATOM   1041 C CZ  . PHE A 1 170 ? -27.57460 16.53953  -27.96018 1.000 43.66000  ? 288 PHE A CZ  1 
ATOM   1042 N N   . ASN A 1 171 ? -29.33845 14.55083  -34.89367 1.000 33.21000  ? 289 ASN A N   1 
ATOM   1043 C CA  . ASN A 1 171 ? -29.24285 13.67556  -36.06017 1.000 40.28000  ? 289 ASN A CA  1 
ATOM   1044 C C   . ASN A 1 171 ? -28.20988 14.17061  -37.07469 1.000 37.88000  ? 289 ASN A C   1 
ATOM   1045 O O   . ASN A 1 171 ? -27.57439 13.35229  -37.75405 1.000 37.53000  ? 289 ASN A O   1 
ATOM   1046 C CB  . ASN A 1 171 ? -30.61365 13.51436  -36.73952 1.000 43.81000  ? 289 ASN A CB  1 
ATOM   1047 C CG  . ASN A 1 171 ? -30.66595 12.29488  -37.67324 1.000 35.65000  ? 289 ASN A CG  1 
ATOM   1048 O OD1 . ASN A 1 171 ? -30.63677 12.42062  -38.90217 1.000 37.12000  ? 289 ASN A OD1 1 
ATOM   1049 N ND2 . ASN A 1 171 ? -30.70854 11.12352  -37.08694 1.000 31.15000  ? 289 ASN A ND2 1 
ATOM   1050 N N   . THR A 1 172 ? -28.02343 15.49076  -37.19588 1.000 38.16000  ? 290 THR A N   1 
ATOM   1051 C CA  . THR A 1 172 ? -27.13847 16.00876  -38.23241 1.000 37.63000  ? 290 THR A CA  1 
ATOM   1052 C C   . THR A 1 172 ? -25.66747 15.87020  -37.87822 1.000 34.36000  ? 290 THR A C   1 
ATOM   1053 O O   . THR A 1 172 ? -24.82344 16.14707  -38.73690 1.000 37.03000  ? 290 THR A O   1 
ATOM   1054 C CB  . THR A 1 172 ? -27.42906 17.48581  -38.52960 1.000 40.00000  ? 290 THR A CB  1 
ATOM   1055 O OG1 . THR A 1 172 ? -27.27962 18.25617  -37.33212 1.000 42.51000  ? 290 THR A OG1 1 
ATOM   1056 C CG2 . THR A 1 172 ? -28.85404 17.65349  -39.04676 1.000 31.16000  ? 290 THR A CG2 1 
ATOM   1057 N N   . VAL A 1 173 ? -25.34154 15.48761  -36.64039 1.000 35.27000  ? 291 VAL A N   1 
ATOM   1058 C CA  . VAL A 1 173 ? -23.96748 15.19898  -36.24130 1.000 39.48000  ? 291 VAL A CA  1 
ATOM   1059 C C   . VAL A 1 173 ? -23.79491 13.73585  -35.89113 1.000 41.50000  ? 291 VAL A C   1 
ATOM   1060 O O   . VAL A 1 173 ? -22.73583 13.34001  -35.37817 1.000 42.05000  ? 291 VAL A O   1 
ATOM   1061 C CB  . VAL A 1 173 ? -23.49709 16.08550  -35.07569 1.000 35.45000  ? 291 VAL A CB  1 
ATOM   1062 C CG1 . VAL A 1 173 ? -23.51565 17.54974  -35.48684 1.000 33.11000  ? 291 VAL A CG1 1 
ATOM   1063 C CG2 . VAL A 1 173 ? -24.34520 15.80639  -33.82201 1.000 36.40000  ? 291 VAL A CG2 1 
ATOM   1064 N N   . PHE A 1 174 ? -24.82451 12.92954  -36.13079 1.000 38.80000  ? 292 PHE A N   1 
ATOM   1065 C CA  . PHE A 1 174 ? -24.76292 11.49444  -35.92162 1.000 38.32000  ? 292 PHE A CA  1 
ATOM   1066 C C   . PHE A 1 174 ? -24.14140 10.82042  -37.12791 1.000 44.84000  ? 292 PHE A C   1 
ATOM   1067 O O   . PHE A 1 174 ? -24.43835 11.17996  -38.27175 1.000 42.76000  ? 292 PHE A O   1 
ATOM   1068 C CB  . PHE A 1 174 ? -26.15971 10.93570  -35.70821 1.000 40.59000  ? 292 PHE A CB  1 
ATOM   1069 C CG  . PHE A 1 174 ? -26.19512 9.47052   -35.42508 1.000 37.13000  ? 292 PHE A CG  1 
ATOM   1070 C CD1 . PHE A 1 174 ? -25.64312 8.96008   -34.26028 1.000 45.96000  ? 292 PHE A CD1 1 
ATOM   1071 C CD2 . PHE A 1 174 ? -26.80958 8.60777   -36.29970 1.000 35.92000  ? 292 PHE A CD2 1 
ATOM   1072 C CE1 . PHE A 1 174 ? -25.69757 7.60190   -33.98808 1.000 46.20000  ? 292 PHE A CE1 1 
ATOM   1073 C CE2 . PHE A 1 174 ? -26.87804 7.25758   -36.02650 1.000 43.20000  ? 292 PHE A CE2 1 
ATOM   1074 C CZ  . PHE A 1 174 ? -26.31904 6.75614   -34.87369 1.000 41.95000  ? 292 PHE A CZ  1 
ATOM   1075 N N   . ASN A 1 175 ? -23.30501 9.81863   -36.85134 1.000 45.53000  ? 293 ASN A N   1 
ATOM   1076 C CA  . ASN A 1 175 ? -22.60047 9.00151   -37.83369 1.000 40.73000  ? 293 ASN A CA  1 
ATOM   1077 C C   . ASN A 1 175 ? -23.10487 7.57520   -37.68562 1.000 41.85000  ? 293 ASN A C   1 
ATOM   1078 O O   . ASN A 1 175 ? -22.75075 6.89079   -36.71996 1.000 47.19000  ? 293 ASN A O   1 
ATOM   1079 C CB  . ASN A 1 175 ? -21.09755 9.07702   -37.58337 1.000 47.28000  ? 293 ASN A CB  1 
ATOM   1080 C CG  . ASN A 1 175 ? -20.29000 8.22594   -38.53672 1.000 48.44000  ? 293 ASN A CG  1 
ATOM   1081 O OD1 . ASN A 1 175 ? -20.76947 7.23906   -39.09939 1.000 53.22000  ? 293 ASN A OD1 1 
ATOM   1082 N ND2 . ASN A 1 175 ? -19.02713 8.58458   -38.68927 1.000 50.87000  ? 293 ASN A ND2 1 
ATOM   1083 N N   . ALA A 1 176 ? -23.89449 7.11643   -38.65404 1.000 43.98000  ? 294 ALA A N   1 
ATOM   1084 C CA  . ALA A 1 176 ? -24.51694 5.79709   -38.55293 1.000 52.15000  ? 294 ALA A CA  1 
ATOM   1085 C C   . ALA A 1 176 ? -23.52939 4.65868   -38.81641 1.000 47.45000  ? 294 ALA A C   1 
ATOM   1086 O O   . ALA A 1 176 ? -23.78497 3.52433   -38.40613 1.000 51.39000  ? 294 ALA A O   1 
ATOM   1087 C CB  . ALA A 1 176 ? -25.72672 5.70213   -39.51121 1.000 40.43000  ? 294 ALA A CB  1 
ATOM   1088 N N   . GLU A 1 177 ? -22.40638 4.92956   -39.47305 1.000 44.84000  ? 295 GLU A N   1 
ATOM   1089 C CA  . GLU A 1 177 ? -21.44187 3.86111   -39.69650 1.000 52.89000  ? 295 GLU A CA  1 
ATOM   1090 C C   . GLU A 1 177 ? -20.68296 3.50569   -38.41656 1.000 55.37000  ? 295 GLU A C   1 
ATOM   1091 O O   . GLU A 1 177 ? -20.30448 2.34075   -38.23618 1.000 61.38000  ? 295 GLU A O   1 
ATOM   1092 C CB  . GLU A 1 177 ? -20.48583 4.24420   -40.83309 1.000 54.91000  ? 295 GLU A CB  1 
ATOM   1093 C CG  . GLU A 1 177 ? -21.20483 4.76963   -42.10692 1.000 51.95000  ? 295 GLU A CG  1 
ATOM   1094 N N   . THR A 1 178 ? -20.47454 4.46425   -37.50396 1.000 50.00000  ? 296 THR A N   1 
ATOM   1095 C CA  . THR A 1 178 ? -19.80566 4.18080   -36.23400 1.000 44.57000  ? 296 THR A CA  1 
ATOM   1096 C C   . THR A 1 178 ? -20.67797 4.39069   -35.00604 1.000 45.94000  ? 296 THR A C   1 
ATOM   1097 O O   . THR A 1 178 ? -20.15515 4.31626   -33.88699 1.000 45.19000  ? 296 THR A O   1 
ATOM   1098 C CB  . THR A 1 178 ? -18.54206 5.03725   -36.05627 1.000 45.13000  ? 296 THR A CB  1 
ATOM   1099 O OG1 . THR A 1 178 ? -18.91172 6.36284   -35.64156 1.000 43.99000  ? 296 THR A OG1 1 
ATOM   1100 C CG2 . THR A 1 178 ? -17.69985 5.08337   -37.34309 1.000 41.22000  ? 296 THR A CG2 1 
ATOM   1101 N N   . GLY A 1 179 ? -21.96707 4.67822   -35.17011 1.000 47.99000  ? 297 GLY A N   1 
ATOM   1102 C CA  . GLY A 1 179 ? -22.87035 4.83716   -34.03218 1.000 41.42000  ? 297 GLY A CA  1 
ATOM   1103 C C   . GLY A 1 179 ? -22.48201 5.94077   -33.07546 1.000 45.49000  ? 297 GLY A C   1 
ATOM   1104 O O   . GLY A 1 179 ? -22.59516 5.76900   -31.85459 1.000 49.96000  ? 297 GLY A O   1 
ATOM   1105 N N   . THR A 1 180 ? -22.02941 7.08027   -33.59471 1.000 42.12000  ? 298 THR A N   1 
ATOM   1106 C CA  . THR A 1 180 ? -21.42202 8.11805   -32.76599 1.000 42.12000  ? 298 THR A CA  1 
ATOM   1107 C C   . THR A 1 180 ? -22.01656 9.48199   -33.09630 1.000 44.33000  ? 298 THR A C   1 
ATOM   1108 O O   . THR A 1 180 ? -22.05652 9.88166   -34.26807 1.000 45.07000  ? 298 THR A O   1 
ATOM   1109 C CB  . THR A 1 180 ? -19.88801 8.17083   -32.95368 1.000 40.49000  ? 298 THR A CB  1 
ATOM   1110 O OG1 . THR A 1 180 ? -19.30052 6.91289   -32.61431 1.000 46.40000  ? 298 THR A OG1 1 
ATOM   1111 C CG2 . THR A 1 180 ? -19.28164 9.23958   -32.06694 1.000 44.37000  ? 298 THR A CG2 1 
ATOM   1112 N N   . TRP A 1 181 ? -22.44807 10.20719  -32.06595 1.000 37.34000  ? 299 TRP A N   1 
ATOM   1113 C CA  . TRP A 1 181 ? -22.77766 11.61913  -32.21018 1.000 39.80000  ? 299 TRP A CA  1 
ATOM   1114 C C   . TRP A 1 181 ? -21.48403 12.40962  -32.06848 1.000 36.73000  ? 299 TRP A C   1 
ATOM   1115 O O   . TRP A 1 181 ? -20.88725 12.45624  -30.98834 1.000 34.98000  ? 299 TRP A O   1 
ATOM   1116 C CB  . TRP A 1 181 ? -23.83804 12.06007  -31.19612 1.000 41.93000  ? 299 TRP A CB  1 
ATOM   1117 C CG  . TRP A 1 181 ? -25.16571 11.42365  -31.47374 1.000 40.53000  ? 299 TRP A CG  1 
ATOM   1118 C CD1 . TRP A 1 181 ? -26.14875 11.87472  -32.31766 1.000 41.28000  ? 299 TRP A CD1 1 
ATOM   1119 C CD2 . TRP A 1 181 ? -25.62826 10.18014  -30.95255 1.000 47.94000  ? 299 TRP A CD2 1 
ATOM   1120 N NE1 . TRP A 1 181 ? -27.20336 10.98827  -32.33737 1.000 37.25000  ? 299 TRP A NE1 1 
ATOM   1121 C CE2 . TRP A 1 181 ? -26.90305 9.93891   -31.50993 1.000 40.96000  ? 299 TRP A CE2 1 
ATOM   1122 C CE3 . TRP A 1 181 ? -25.08702 9.24386   -30.06500 1.000 44.47000  ? 299 TRP A CE3 1 
ATOM   1123 C CZ2 . TRP A 1 181 ? -27.63562 8.81741   -31.20373 1.000 41.38000  ? 299 TRP A CZ2 1 
ATOM   1124 C CZ3 . TRP A 1 181 ? -25.81059 8.13837   -29.76879 1.000 40.32000  ? 299 TRP A CZ3 1 
ATOM   1125 C CH2 . TRP A 1 181 ? -27.07739 7.93014   -30.33014 1.000 45.65000  ? 299 TRP A CH2 1 
ATOM   1126 N N   . GLU A 1 182 ? -21.05410 13.03245  -33.16603 1.000 39.03000  ? 300 GLU A N   1 
ATOM   1127 C CA  . GLU A 1 182 ? -19.80143 13.79103  -33.21036 1.000 39.44000  ? 300 GLU A CA  1 
ATOM   1128 C C   . GLU A 1 182 ? -20.10812 15.25872  -32.92455 1.000 38.89000  ? 300 GLU A C   1 
ATOM   1129 O O   . GLU A 1 182 ? -20.54529 16.00605  -33.80419 1.000 42.04000  ? 300 GLU A O   1 
ATOM   1130 C CB  . GLU A 1 182 ? -19.11008 13.57212  -34.55336 1.000 45.22000  ? 300 GLU A CB  1 
ATOM   1131 C CG  . GLU A 1 182 ? -19.01336 12.06536  -34.89523 1.000 48.74000  ? 300 GLU A CG  1 
ATOM   1132 C CD  . GLU A 1 182 ? -18.19098 11.74045  -36.14527 1.000 64.58000  ? 300 GLU A CD  1 
ATOM   1133 O OE1 . GLU A 1 182 ? -18.12518 12.58703  -37.06776 1.000 67.57000  ? 300 GLU A OE1 1 
ATOM   1134 O OE2 . GLU A 1 182 ? -17.63648 10.61174  -36.21283 1.000 65.07000  ? 300 GLU A OE2 1 
ATOM   1135 N N   . CYS A 1 183 ? -19.89353 15.66208  -31.67528 1.000 44.03000  ? 301 CYS A N   1 
ATOM   1136 C CA  . CYS A 1 183 ? -20.22820 16.99465  -31.18455 1.000 41.84000  ? 301 CYS A CA  1 
ATOM   1137 C C   . CYS A 1 183 ? -18.95560 17.80308  -30.96184 1.000 41.29000  ? 301 CYS A C   1 
ATOM   1138 O O   . CYS A 1 183 ? -18.59595 18.12757  -29.83159 1.000 41.37000  ? 301 CYS A O   1 
ATOM   1139 C CB  . CYS A 1 183 ? -21.03140 16.89753  -29.88076 1.000 38.02000  ? 301 CYS A CB  1 
ATOM   1140 S SG  . CYS A 1 183 ? -22.51694 15.91297  -30.03461 1.000 41.32000  ? 301 CYS A SG  1 
ATOM   1141 N N   . GLY A 1 184 ? -18.27955 18.14601  -32.04752 1.000 40.89000  ? 302 GLY A N   1 
ATOM   1142 C CA  . GLY A 1 184 ? -17.07093 18.94144  -31.87783 1.000 43.07000  ? 302 GLY A CA  1 
ATOM   1143 C C   . GLY A 1 184 ? -16.01672 18.15046  -31.12810 1.000 43.76000  ? 302 GLY A C   1 
ATOM   1144 O O   . GLY A 1 184 ? -15.70115 17.00981  -31.48771 1.000 51.77000  ? 302 GLY A O   1 
ATOM   1145 N N   . ARG A 1 185 ? -15.48018 18.74207  -30.05565 1.000 43.42000  ? 303 ARG A N   1 
ATOM   1146 C CA  . ARG A 1 185 ? -14.45404 18.07404  -29.24885 1.000 50.51000  ? 303 ARG A CA  1 
ATOM   1147 C C   . ARG A 1 185 ? -15.00865 16.87435  -28.47866 1.000 46.89000  ? 303 ARG A C   1 
ATOM   1148 O O   . ARG A 1 185 ? -14.23435 16.00844  -28.06003 1.000 50.96000  ? 303 ARG A O   1 
ATOM   1149 C CB  . ARG A 1 185 ? -13.79465 19.07076  -28.27115 1.000 37.08000  ? 303 ARG A CB  1 
ATOM   1150 N N   . LEU A 1 186 ? -16.32065 16.79566  -28.29395 1.000 45.82000  ? 304 LEU A N   1 
ATOM   1151 C CA  . LEU A 1 186 ? -16.95530 15.69097  -27.58771 1.000 44.92000  ? 304 LEU A CA  1 
ATOM   1152 C C   . LEU A 1 186 ? -17.53267 14.68530  -28.57641 1.000 44.61000  ? 304 LEU A C   1 
ATOM   1153 O O   . LEU A 1 186 ? -17.98763 15.04274  -29.66529 1.000 46.04000  ? 304 LEU A O   1 
ATOM   1154 C CB  . LEU A 1 186 ? -18.06769 16.19494  -26.66562 1.000 44.80000  ? 304 LEU A CB  1 
ATOM   1155 C CG  . LEU A 1 186 ? -17.61825 16.95140  -25.41410 1.000 46.44000  ? 304 LEU A CG  1 
ATOM   1156 C CD1 . LEU A 1 186 ? -18.71475 17.88064  -24.92575 1.000 42.47000  ? 304 LEU A CD1 1 
ATOM   1157 C CD2 . LEU A 1 186 ? -17.21403 15.97094  -24.32060 1.000 46.32000  ? 304 LEU A CD2 1 
ATOM   1158 N N   . SER A 1 187 ? -17.52619 13.42107  -28.17715 1.000 44.46000  ? 305 SER A N   1 
ATOM   1159 C CA  . SER A 1 187 ? -18.09858 12.34928  -28.97089 1.000 42.03000  ? 305 SER A CA  1 
ATOM   1160 C C   . SER A 1 187 ? -18.84635 11.43140  -28.02757 1.000 45.78000  ? 305 SER A C   1 
ATOM   1161 O O   . SER A 1 187 ? -18.36243 11.13897  -26.93065 1.000 45.70000  ? 305 SER A O   1 
ATOM   1162 C CB  . SER A 1 187 ? -17.02709 11.54318  -29.69917 1.000 46.40000  ? 305 SER A CB  1 
ATOM   1163 O OG  . SER A 1 187 ? -16.46722 12.28604  -30.74963 1.000 57.01000  ? 305 SER A OG  1 
ATOM   1164 N N   . TYR A 1 188 ? -20.01707 10.97514  -28.45705 1.000 47.03000  ? 306 TYR A N   1 
ATOM   1165 C CA  . TYR A 1 188 ? -20.79678 9.98836   -27.72177 1.000 46.68000  ? 306 TYR A CA  1 
ATOM   1166 C C   . TYR A 1 188 ? -20.96108 8.77382   -28.61952 1.000 43.96000  ? 306 TYR A C   1 
ATOM   1167 O O   . TYR A 1 188 ? -21.58392 8.86917   -29.67658 1.000 45.86000  ? 306 TYR A O   1 
ATOM   1168 C CB  . TYR A 1 188 ? -22.14710 10.55753  -27.31769 1.000 44.42000  ? 306 TYR A CB  1 
ATOM   1169 C CG  . TYR A 1 188 ? -22.04481 11.86515  -26.58890 1.000 45.29000  ? 306 TYR A CG  1 
ATOM   1170 C CD1 . TYR A 1 188 ? -21.68208 11.91652  -25.24780 1.000 44.77000  ? 306 TYR A CD1 1 
ATOM   1171 C CD2 . TYR A 1 188 ? -22.31621 13.05041  -27.23726 1.000 44.22000  ? 306 TYR A CD2 1 
ATOM   1172 C CE1 . TYR A 1 188 ? -21.59973 13.12117  -24.58108 1.000 39.77000  ? 306 TYR A CE1 1 
ATOM   1173 C CE2 . TYR A 1 188 ? -22.23285 14.25007  -26.58854 1.000 44.80000  ? 306 TYR A CE2 1 
ATOM   1174 C CZ  . TYR A 1 188 ? -21.88111 14.28945  -25.26445 1.000 44.82000  ? 306 TYR A CZ  1 
ATOM   1175 O OH  . TYR A 1 188 ? -21.80777 15.52011  -24.63771 1.000 41.42000  ? 306 TYR A OH  1 
ATOM   1176 N N   . CYS A 1 189 ? -20.36866 7.65185   -28.22607 1.000 53.99000  ? 307 CYS A N   1 
ATOM   1177 C CA  A CYS A 1 189 ? -20.43397 6.41427   -28.98881 0.330 52.87000  ? 307 CYS A CA  1 
ATOM   1178 C CA  B CYS A 1 189 ? -20.42997 6.41427   -28.99181 0.670 53.14000  ? 307 CYS A CA  1 
ATOM   1179 C C   . CYS A 1 189 ? -21.35367 5.42945   -28.28756 1.000 54.17000  ? 307 CYS A C   1 
ATOM   1180 O O   . CYS A 1 189 ? -21.30083 5.28175   -27.06163 1.000 56.17000  ? 307 CYS A O   1 
ATOM   1181 C CB  A CYS A 1 189 ? -19.04667 5.78598   -29.16192 0.330 51.08000  ? 307 CYS A CB  1 
ATOM   1182 C CB  B CYS A 1 189 ? -19.03566 5.77999   -29.18092 0.670 52.31000  ? 307 CYS A CB  1 
ATOM   1183 S SG  A CYS A 1 189 ? -19.07481 4.14341   -29.92289 0.330 57.12000  ? 307 CYS A SG  1 
ATOM   1184 S SG  B CYS A 1 189 ? -17.63415 6.50906   -28.24423 0.670 65.80000  ? 307 CYS A SG  1 
ATOM   1185 N N   . LEU A 1 190 ? -22.20124 4.76954   -29.06610 1.000 58.18000  ? 308 LEU A N   1 
ATOM   1186 C CA  . LEU A 1 190 ? -23.02987 3.69686   -28.53288 1.000 64.57000  ? 308 LEU A CA  1 
ATOM   1187 C C   . LEU A 1 190 ? -22.16638 2.46508   -28.26945 1.000 66.59000  ? 308 LEU A C   1 
ATOM   1188 O O   . LEU A 1 190 ? -21.36504 2.06393   -29.12154 1.000 59.31000  ? 308 LEU A O   1 
ATOM   1189 C CB  . LEU A 1 190 ? -24.14754 3.35395   -29.51629 1.000 56.89000  ? 308 LEU A CB  1 
ATOM   1190 C CG  . LEU A 1 190 ? -25.42191 4.19436   -29.46203 1.000 50.84000  ? 308 LEU A CG  1 
ATOM   1191 C CD1 . LEU A 1 190 ? -26.15662 4.06780   -30.77224 1.000 44.29000  ? 308 LEU A CD1 1 
ATOM   1192 C CD2 . LEU A 1 190 ? -26.31895 3.78329   -28.31544 1.000 56.24000  ? 308 LEU A CD2 1 
ATOM   1193 N N   . GLU A 1 191 ? -22.34533 1.86131   -27.09183 1.000 76.27000  ? 309 GLU A N   1 
ATOM   1194 C CA  . GLU A 1 191 ? -21.55490 0.70641   -26.67337 1.000 90.54000  ? 309 GLU A CA  1 
ATOM   1195 C C   . GLU A 1 191 ? -22.11322 -0.58948  -27.27523 1.000 94.89000  ? 309 GLU A C   1 
ATOM   1196 O O   . GLU A 1 191 ? -23.31912 -0.85206  -27.19261 1.000 92.18000  ? 309 GLU A O   1 
ATOM   1197 C CB  . GLU A 1 191 ? -21.53015 0.62752   -25.14141 1.000 85.39000  ? 309 GLU A CB  1 
ATOM   1198 N N   . ASP A 1 192 ? -21.22976 -1.40374  -27.86655 1.000 104.59000 ? 310 ASP A N   1 
ATOM   1199 C CA  . ASP A 1 192 ? -21.64309 -2.63153  -28.54834 1.000 108.32000 ? 310 ASP A CA  1 
ATOM   1200 C C   . ASP A 1 192 ? -22.22783 -3.64936  -27.56505 1.000 108.80000 ? 310 ASP A C   1 
ATOM   1201 O O   . ASP A 1 192 ? -21.79099 -3.76284  -26.41504 1.000 106.58000 ? 310 ASP A O   1 
ATOM   1202 C CB  . ASP A 1 192 ? -20.45968 -3.25056  -29.30049 1.000 85.08000  ? 310 ASP A CB  1 
ATOM   1203 N N   . THR A 1 193 ? -23.22641 -4.40152  -28.03768 1.000 104.63000 ? 311 THR A N   1 
ATOM   1204 C CA  . THR A 1 193 ? -23.96916 -5.33335  -27.18336 1.000 107.40000 ? 311 THR A CA  1 
ATOM   1205 C C   . THR A 1 193 ? -24.73855 -6.37621  -27.99712 1.000 106.84000 ? 311 THR A C   1 
ATOM   1206 O O   . THR A 1 193 ? -25.97155 -6.36873  -28.03434 1.000 98.51000  ? 311 THR A O   1 
ATOM   1207 C CB  . THR A 1 193 ? -24.96566 -4.58632  -26.26911 1.000 99.80000  ? 311 THR A CB  1 
ATOM   1208 N N   . PHE A 1 197 ? -26.51449 -4.03552  -33.89607 1.000 93.43000  ? 315 PHE A N   1 
ATOM   1209 C CA  . PHE A 1 197 ? -27.38872 -3.16844  -34.68272 1.000 102.32000 ? 315 PHE A CA  1 
ATOM   1210 C C   . PHE A 1 197 ? -28.83251 -3.68011  -34.61729 1.000 104.12000 ? 315 PHE A C   1 
ATOM   1211 O O   . PHE A 1 197 ? -29.79279 -2.93239  -34.86003 1.000 96.37000  ? 315 PHE A O   1 
ATOM   1212 C CB  . PHE A 1 197 ? -26.91049 -3.08237  -36.14058 1.000 89.70000  ? 315 PHE A CB  1 
ATOM   1213 N N   . GLN A 1 198 ? -28.98201 -4.96237  -34.28407 1.000 102.18000 ? 316 GLN A N   1 
ATOM   1214 C CA  . GLN A 1 198 ? -30.30977 -5.55401  -34.18866 1.000 101.04000 ? 316 GLN A CA  1 
ATOM   1215 C C   . GLN A 1 198 ? -30.90609 -5.42209  -32.79170 1.000 97.55000  ? 316 GLN A C   1 
ATOM   1216 O O   . GLN A 1 198 ? -32.13416 -5.30871  -32.66386 1.000 94.52000  ? 316 GLN A O   1 
ATOM   1217 C CB  . GLN A 1 198 ? -30.26404 -7.02774  -34.61352 1.000 93.36000  ? 316 GLN A CB  1 
ATOM   1218 N N   . GLN A 1 199 ? -30.06627 -5.43834  -31.74355 1.000 96.31000  ? 317 GLN A N   1 
ATOM   1219 C CA  . GLN A 1 199 ? -30.53466 -5.12034  -30.39445 1.000 94.45000  ? 317 GLN A CA  1 
ATOM   1220 C C   . GLN A 1 199 ? -30.63336 -3.61351  -30.17558 1.000 100.40000 ? 317 GLN A C   1 
ATOM   1221 O O   . GLN A 1 199 ? -31.45571 -3.16435  -29.36547 1.000 96.29000  ? 317 GLN A O   1 
ATOM   1222 C CB  . GLN A 1 199 ? -29.61858 -5.74156  -29.33365 1.000 78.65000  ? 317 GLN A CB  1 
ATOM   1223 N N   . LEU A 1 200 ? -29.81458 -2.82273  -30.88697 1.000 106.47000 ? 318 LEU A N   1 
ATOM   1224 C CA  . LEU A 1 200 ? -29.91723 -1.36382  -30.81913 1.000 89.98000  ? 318 LEU A CA  1 
ATOM   1225 C C   . LEU A 1 200 ? -31.23233 -0.87904  -31.41709 1.000 83.69000  ? 318 LEU A C   1 
ATOM   1226 O O   . LEU A 1 200 ? -31.97578 -0.12775  -30.77378 1.000 80.49000  ? 318 LEU A O   1 
ATOM   1227 C CB  . LEU A 1 200 ? -28.73038 -0.70987  -31.53853 1.000 80.93000  ? 318 LEU A CB  1 
ATOM   1228 N N   . LEU A 1 201 ? -31.55391 -1.32447  -32.63741 1.000 80.35000  ? 319 LEU A N   1 
ATOM   1229 C CA  . LEU A 1 201 ? -32.75597 -0.87858  -33.34337 1.000 80.62000  ? 319 LEU A CA  1 
ATOM   1230 C C   . LEU A 1 201 ? -34.03392 -1.30657  -32.61486 1.000 74.65000  ? 319 LEU A C   1 
ATOM   1231 O O   . LEU A 1 201 ? -35.14990 -1.13576  -33.12796 1.000 71.13000  ? 319 LEU A O   1 
ATOM   1232 C CB  . LEU A 1 201 ? -32.75648 -1.39973  -34.79168 1.000 75.67000  ? 319 LEU A CB  1 
ATOM   1233 N N   . LEU A 1 202 ? -33.88290 -1.86521  -31.41316 1.000 76.11000  ? 320 LEU A N   1 
ATOM   1234 C CA  . LEU A 1 202 ? -35.04494 -2.13421  -30.57853 1.000 78.70000  ? 320 LEU A CA  1 
ATOM   1235 C C   . LEU A 1 202 ? -35.49362 -0.87484  -29.84087 1.000 77.06000  ? 320 LEU A C   1 
ATOM   1236 O O   . LEU A 1 202 ? -36.69876 -0.60342  -29.74193 1.000 75.54000  ? 320 LEU A O   1 
ATOM   1237 C CB  . LEU A 1 202 ? -34.73062 -3.26264  -29.59913 1.000 79.37000  ? 320 LEU A CB  1 
ATOM   1238 C CG  . LEU A 1 202 ? -34.66290 -4.63522  -30.26793 1.000 80.92000  ? 320 LEU A CG  1 
ATOM   1239 C CD1 . LEU A 1 202 ? -34.05761 -5.68051  -29.32743 1.000 86.79000  ? 320 LEU A CD1 1 
ATOM   1240 C CD2 . LEU A 1 202 ? -36.03963 -5.03853  -30.77342 1.000 72.27000  ? 320 LEU A CD2 1 
ATOM   1241 N N   . GLU A 1 203 ? -34.54506 -0.08071  -29.34823 1.000 69.35000  ? 321 GLU A N   1 
ATOM   1242 C CA  . GLU A 1 203 ? -34.88674 1.16274   -28.66256 1.000 63.79000  ? 321 GLU A CA  1 
ATOM   1243 C C   . GLU A 1 203 ? -35.39600 2.18411   -29.67706 1.000 59.93000  ? 321 GLU A C   1 
ATOM   1244 O O   . GLU A 1 203 ? -34.64100 2.57697   -30.57669 1.000 56.31000  ? 321 GLU A O   1 
ATOM   1245 C CB  . GLU A 1 203 ? -33.67211 1.69383   -27.90803 1.000 55.03000  ? 321 GLU A CB  1 
ATOM   1246 C CG  . GLU A 1 203 ? -34.00178 2.83013   -26.96142 1.000 63.11000  ? 321 GLU A CG  1 
ATOM   1247 C CD  . GLU A 1 203 ? -34.77582 2.39407   -25.73582 1.000 58.97000  ? 321 GLU A CD  1 
ATOM   1248 O OE1 . GLU A 1 203 ? -34.47745 1.32687   -25.17839 1.000 65.62000  ? 321 GLU A OE1 1 
ATOM   1249 O OE2 . GLU A 1 203 ? -35.69921 3.12243   -25.33056 1.000 67.80000  ? 321 GLU A OE2 1 
ATOM   1250 N N   . PRO A 1 204 ? -36.65820 2.62151   -29.58803 1.000 55.13000  ? 322 PRO A N   1 
ATOM   1251 C CA  . PRO A 1 204 ? -37.22438 3.47289   -30.65664 1.000 54.68000  ? 322 PRO A CA  1 
ATOM   1252 C C   . PRO A 1 204 ? -36.40986 4.71345   -31.00476 1.000 51.22000  ? 322 PRO A C   1 
ATOM   1253 O O   . PRO A 1 204 ? -36.35080 5.08116   -32.18153 1.000 54.29000  ? 322 PRO A O   1 
ATOM   1254 C CB  . PRO A 1 204 ? -38.61364 3.83395   -30.10168 1.000 53.33000  ? 322 PRO A CB  1 
ATOM   1255 C CG  . PRO A 1 204 ? -38.98027 2.63230   -29.27546 1.000 48.83000  ? 322 PRO A CG  1 
ATOM   1256 C CD  . PRO A 1 204 ? -37.67821 2.22148   -28.60146 1.000 51.92000  ? 322 PRO A CD  1 
ATOM   1257 N N   . MET A 1 205 ? -35.77933 5.37916   -30.03925 1.000 55.88000  ? 323 MET A N   1 
ATOM   1258 C CA  . MET A 1 205 ? -34.99578 6.55571   -30.40241 1.000 49.78000  ? 323 MET A CA  1 
ATOM   1259 C C   . MET A 1 205 ? -33.72048 6.19471   -31.14439 1.000 49.78000  ? 323 MET A C   1 
ATOM   1260 O O   . MET A 1 205 ? -33.17172 7.03837   -31.86379 1.000 47.71000  ? 323 MET A O   1 
ATOM   1261 C CB  . MET A 1 205 ? -34.65037 7.39314   -29.16886 1.000 46.32000  ? 323 MET A CB  1 
ATOM   1262 C CG  . MET A 1 205 ? -34.15393 8.80554   -29.48594 1.000 46.09000  ? 323 MET A CG  1 
ATOM   1263 S SD  . MET A 1 205 ? -35.35725 9.90052   -30.33452 1.000 55.16000  ? 323 MET A SD  1 
ATOM   1264 C CE  . MET A 1 205 ? -34.39824 10.46377  -31.74801 1.000 45.04000  ? 323 MET A CE  1 
ATOM   1265 N N   . LEU A 1 206 ? -33.23497 4.97084   -31.01502 1.000 46.57000  ? 324 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 206 ? -32.01671 4.70281   -31.75695 1.000 43.54000  ? 324 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 206 ? -32.35628 4.32551   -33.19424 1.000 49.42000  ? 324 LEU A C   1 
ATOM   1268 O O   . LEU A 1 206 ? -31.66229 4.74636   -34.12686 1.000 51.13000  ? 324 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 206 ? -31.21535 3.58578   -31.09746 1.000 48.30000  ? 324 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 206 ? -30.44175 3.97138   -29.83609 1.000 54.50000  ? 324 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 206 ? -29.43620 5.09196   -30.07025 1.000 62.60000  ? 324 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 206 ? -31.36110 4.29030   -28.69607 1.000 61.02000  ? 324 LEU A CD2 1 
ATOM   1273 N N   . LYS A 1 207 ? -33.43891 3.55514   -33.37889 1.000 48.75000  ? 325 LYS A N   1 
ATOM   1274 C CA  . LYS A 1 207 ? -33.93252 3.21771   -34.71318 1.000 49.53000  ? 325 LYS A CA  1 
ATOM   1275 C C   . LYS A 1 207 ? -34.23092 4.47505   -35.51850 1.000 46.30000  ? 325 LYS A C   1 
ATOM   1276 O O   . LYS A 1 207 ? -33.85175 4.58091   -36.69136 1.000 46.10000  ? 325 LYS A O   1 
ATOM   1277 C CB  . LYS A 1 207 ? -35.18415 2.34009   -34.59193 1.000 54.56000  ? 325 LYS A CB  1 
ATOM   1278 C CG  . LYS A 1 207 ? -35.69264 1.72763   -35.89438 1.000 55.72000  ? 325 LYS A CG  1 
ATOM   1279 C CD  . LYS A 1 207 ? -37.16850 1.36092   -35.79087 1.000 58.56000  ? 325 LYS A CD  1 
ATOM   1280 N N   . PHE A 1 208 ? -34.90746 5.44039   -34.88505 1.000 44.07000  ? 326 PHE A N   1 
ATOM   1281 C CA  . PHE A 1 208 ? -35.18692 6.74062   -35.49034 1.000 40.29000  ? 326 PHE A CA  1 
ATOM   1282 C C   . PHE A 1 208 ? -33.93308 7.37352   -36.08674 1.000 42.16000  ? 326 PHE A C   1 
ATOM   1283 O O   . PHE A 1 208 ? -33.91604 7.75921   -37.25851 1.000 41.25000  ? 326 PHE A O   1 
ATOM   1284 C CB  . PHE A 1 208 ? -35.78652 7.65973   -34.42991 1.000 43.46000  ? 326 PHE A CB  1 
ATOM   1285 C CG  . PHE A 1 208 ? -36.24999 8.97384   -34.96123 1.000 43.76000  ? 326 PHE A CG  1 
ATOM   1286 C CD1 . PHE A 1 208 ? -35.38046 10.06326  -35.01543 1.000 45.16000  ? 326 PHE A CD1 1 
ATOM   1287 C CD2 . PHE A 1 208 ? -37.55598 9.12654   -35.41838 1.000 42.31000  ? 326 PHE A CD2 1 
ATOM   1288 C CE1 . PHE A 1 208 ? -35.80690 11.29037  -35.52778 1.000 40.27000  ? 326 PHE A CE1 1 
ATOM   1289 C CE2 . PHE A 1 208 ? -38.00042 10.35064  -35.92974 1.000 48.40000  ? 326 PHE A CE2 1 
ATOM   1290 C CZ  . PHE A 1 208 ? -37.11889 11.43906  -35.97794 1.000 47.02000  ? 326 PHE A CZ  1 
ATOM   1291 N N   . HIS A 1 209 ? -32.86728 7.48752   -35.29347 1.000 40.56000  ? 327 HIS A N   1 
ATOM   1292 C CA  . HIS A 1 209 ? -31.66448 8.15334   -35.78386 1.000 36.19000  ? 327 HIS A CA  1 
ATOM   1293 C C   . HIS A 1 209 ? -31.10694 7.44229   -37.00118 1.000 42.27000  ? 327 HIS A C   1 
ATOM   1294 O O   . HIS A 1 209 ? -30.60206 8.09006   -37.92670 1.000 41.07000  ? 327 HIS A O   1 
ATOM   1295 C CB  . HIS A 1 209 ? -30.59872 8.23116   -34.68762 1.000 34.68000  ? 327 HIS A CB  1 
ATOM   1296 C CG  . HIS A 1 209 ? -30.75340 9.41756   -33.78595 1.000 31.54000  ? 327 HIS A CG  1 
ATOM   1297 N ND1 . HIS A 1 209 ? -30.45889 10.69993  -34.18714 1.000 36.50000  ? 327 HIS A ND1 1 
ATOM   1298 C CD2 . HIS A 1 209 ? -31.18068 9.51662   -32.50697 1.000 36.49000  ? 327 HIS A CD2 1 
ATOM   1299 C CE1 . HIS A 1 209 ? -30.70344 11.54224  -33.19769 1.000 34.94000  ? 327 HIS A CE1 1 
ATOM   1300 N NE2 . HIS A 1 209 ? -31.14033 10.84744  -32.16518 1.000 38.61000  ? 327 HIS A NE2 1 
ATOM   1301 N N   . TYR A 1 210 ? -31.18536 6.10827   -37.02397 1.000 43.65000  ? 328 TYR A N   1 
ATOM   1302 C CA  . TYR A 1 210 ? -30.65482 5.37618   -38.16431 1.000 36.07000  ? 328 TYR A CA  1 
ATOM   1303 C C   . TYR A 1 210 ? -31.53869 5.59150   -39.38034 1.000 41.90000  ? 328 TYR A C   1 
ATOM   1304 O O   . TYR A 1 210 ? -31.04062 5.87936   -40.47608 1.000 44.32000  ? 328 TYR A O   1 
ATOM   1305 C CB  . TYR A 1 210 ? -30.51323 3.88304   -37.82316 1.000 41.30000  ? 328 TYR A CB  1 
ATOM   1306 C CG  . TYR A 1 210 ? -29.22824 3.59115   -37.06309 1.000 41.50000  ? 328 TYR A CG  1 
ATOM   1307 C CD1 . TYR A 1 210 ? -28.03003 3.38607   -37.73499 1.000 44.80000  ? 328 TYR A CD1 1 
ATOM   1308 C CD2 . TYR A 1 210 ? -29.20749 3.57334   -35.67010 1.000 42.97000  ? 328 TYR A CD2 1 
ATOM   1309 C CE1 . TYR A 1 210 ? -26.84705 3.15119   -37.04791 1.000 45.54000  ? 328 TYR A CE1 1 
ATOM   1310 C CE2 . TYR A 1 210 ? -28.03952 3.32644   -34.96503 1.000 42.10000  ? 328 TYR A CE2 1 
ATOM   1311 C CZ  . TYR A 1 210 ? -26.85330 3.11637   -35.65993 1.000 52.74000  ? 328 TYR A CZ  1 
ATOM   1312 O OH  . TYR A 1 210 ? -25.67032 2.88948   -34.96485 1.000 51.61000  ? 328 TYR A OH  1 
ATOM   1313 N N   . MET A 1 211 ? -32.85968 5.48681   -39.19265 1.000 38.75000  ? 329 MET A N   1 
ATOM   1314 C CA  A MET A 1 211 ? -33.79756 5.66905   -40.29372 0.530 41.54000  ? 329 MET A CA  1 
ATOM   1315 C CA  B MET A 1 211 ? -33.77255 5.65807   -40.30972 0.470 40.72000  ? 329 MET A CA  1 
ATOM   1316 C C   . MET A 1 211 ? -33.69507 7.07242   -40.85687 1.000 42.93000  ? 329 MET A C   1 
ATOM   1317 O O   . MET A 1 211 ? -33.64993 7.27116   -42.07875 1.000 49.33000  ? 329 MET A O   1 
ATOM   1318 C CB  A MET A 1 211 ? -35.22953 5.41014   -39.82313 0.530 44.96000  ? 329 MET A CB  1 
ATOM   1319 C CB  B MET A 1 211 ? -35.19848 5.31319   -39.88418 0.470 45.14000  ? 329 MET A CB  1 
ATOM   1320 C CG  A MET A 1 211 ? -35.69189 3.96797   -39.86507 0.530 51.81000  ? 329 MET A CG  1 
ATOM   1321 C CG  B MET A 1 211 ? -35.42688 3.82793   -39.61310 0.470 51.42000  ? 329 MET A CG  1 
ATOM   1322 S SD  A MET A 1 211 ? -37.39494 3.81987   -39.26747 0.530 73.54000  ? 329 MET A SD  1 
ATOM   1323 S SD  B MET A 1 211 ? -35.32815 2.78084   -41.08770 0.470 73.54000  ? 329 MET A SD  1 
ATOM   1324 C CE  A MET A 1 211 ? -38.28910 4.71522   -40.52811 0.530 51.82000  ? 329 MET A CE  1 
ATOM   1325 C CE  B MET A 1 211 ? -33.65388 2.14252   -40.98576 0.470 47.41000  ? 329 MET A CE  1 
ATOM   1326 N N   . LEU A 1 212 ? -33.67867 8.06691   -39.97029 1.000 38.79000  ? 330 LEU A N   1 
ATOM   1327 C CA  . LEU A 1 212 ? -33.60119 9.44421   -40.42246 1.000 37.89000  ? 330 LEU A CA  1 
ATOM   1328 C C   . LEU A 1 212 ? -32.31215 9.68223   -41.18908 1.000 41.93000  ? 330 LEU A C   1 
ATOM   1329 O O   . LEU A 1 212 ? -32.32520 10.25786  -42.28375 1.000 41.25000  ? 330 LEU A O   1 
ATOM   1330 C CB  . LEU A 1 212 ? -33.70682 10.39247  -39.23692 1.000 41.68000  ? 330 LEU A CB  1 
ATOM   1331 C CG  . LEU A 1 212 ? -33.91438 11.84163  -39.65911 1.000 41.71000  ? 330 LEU A CG  1 
ATOM   1332 C CD1 . LEU A 1 212 ? -35.00622 11.92578  -40.73326 1.000 40.57000  ? 330 LEU A CD1 1 
ATOM   1333 C CD2 . LEU A 1 212 ? -34.24598 12.68977  -38.44567 1.000 37.20000  ? 330 LEU A CD2 1 
ATOM   1334 N N   . LYS A 1 213 ? -31.18505 9.22040   -40.64015 1.000 40.39000  ? 331 LYS A N   1 
ATOM   1335 C CA  . LYS A 1 213 ? -29.91801 9.42536   -41.32879 1.000 38.64000  ? 331 LYS A CA  1 
ATOM   1336 C C   . LYS A 1 213 ? -29.91847 8.77316   -42.69618 1.000 37.16000  ? 331 LYS A C   1 
ATOM   1337 O O   . LYS A 1 213 ? -29.30453 9.29398   -43.63676 1.000 36.85000  ? 331 LYS A O   1 
ATOM   1338 C CB  . LYS A 1 213 ? -28.76693 8.88738   -40.50090 1.000 31.67000  ? 331 LYS A CB  1 
ATOM   1339 C CG  . LYS A 1 213 ? -27.45012 9.48118   -40.88930 1.000 33.34000  ? 331 LYS A CG  1 
ATOM   1340 C CD  . LYS A 1 213 ? -27.19183 10.84592  -40.25245 1.000 42.75000  ? 331 LYS A CD  1 
ATOM   1341 C CE  . LYS A 1 213 ? -25.93200 11.48082  -40.84885 1.000 27.86000  ? 331 LYS A CE  1 
ATOM   1342 N NZ  . LYS A 1 213 ? -25.81769 12.91667  -40.50298 1.000 40.88000  ? 331 LYS A NZ  1 
ATOM   1343 N N   . LYS A 1 214 ? -30.62496 7.65693   -42.83396 1.000 44.34000  ? 332 LYS A N   1 
ATOM   1344 C CA  . LYS A 1 214 ? -30.63640 6.92467   -44.09640 1.000 47.89000  ? 332 LYS A CA  1 
ATOM   1345 C C   . LYS A 1 214 ? -31.31555 7.72202   -45.19905 1.000 46.03000  ? 332 LYS A C   1 
ATOM   1346 O O   . LYS A 1 214 ? -31.01424 7.51784   -46.38112 1.000 47.34000  ? 332 LYS A O   1 
ATOM   1347 C CB  . LYS A 1 214 ? -31.33885 5.57325   -43.90532 1.000 50.47000  ? 332 LYS A CB  1 
ATOM   1348 C CG  . LYS A 1 214 ? -30.50724 4.36585   -44.30387 1.000 56.36000  ? 332 LYS A CG  1 
ATOM   1349 N N   . LEU A 1 215 ? -32.20902 8.63841   -44.82668 1.000 41.45000  ? 333 LEU A N   1 
ATOM   1350 C CA  . LEU A 1 215 ? -32.95819 9.42265   -45.79236 1.000 39.03000  ? 333 LEU A CA  1 
ATOM   1351 C C   . LEU A 1 215 ? -32.08150 10.43846  -46.52060 1.000 42.24000  ? 333 LEU A C   1 
ATOM   1352 O O   . LEU A 1 215 ? -32.45349 10.88894  -47.61540 1.000 40.87000  ? 333 LEU A O   1 
ATOM   1353 C CB  . LEU A 1 215 ? -34.10763 10.12472  -45.06316 1.000 42.92000  ? 333 LEU A CB  1 
ATOM   1354 C CG  . LEU A 1 215 ? -35.22732 9.20993   -44.56190 1.000 39.00000  ? 333 LEU A CG  1 
ATOM   1355 C CD1 . LEU A 1 215 ? -36.37778 10.03211  -44.01863 1.000 43.55000  ? 333 LEU A CD1 1 
ATOM   1356 C CD2 . LEU A 1 215 ? -35.70775 8.38939   -45.70647 1.000 40.61000  ? 333 LEU A CD2 1 
ATOM   1357 N N   . GLN A 1 216 ? -30.95678 10.83460  -45.92016 1.000 39.03000  ? 334 GLN A N   1 
ATOM   1358 C CA  . GLN A 1 216 ? -29.98006 11.73239  -46.53745 1.000 37.46000  ? 334 GLN A CA  1 
ATOM   1359 C C   . GLN A 1 216 ? -30.58260 13.09631  -46.85276 1.000 38.22000  ? 334 GLN A C   1 
ATOM   1360 O O   . GLN A 1 216 ? -30.44063 13.62602  -47.95542 1.000 50.14000  ? 334 GLN A O   1 
ATOM   1361 C CB  . GLN A 1 216 ? -29.36155 11.09339  -47.77771 1.000 40.03000  ? 334 GLN A CB  1 
ATOM   1362 C CG  . GLN A 1 216 ? -28.11826 10.27772  -47.40396 1.000 50.18000  ? 334 GLN A CG  1 
ATOM   1363 C CD  . GLN A 1 216 ? -27.58766 9.38360   -48.52039 1.000 62.00000  ? 334 GLN A CD  1 
ATOM   1364 O OE1 . GLN A 1 216 ? -28.34825 8.73870   -49.24891 1.000 61.77000  ? 334 GLN A OE1 1 
ATOM   1365 N NE2 . GLN A 1 216 ? -26.26662 9.33826   -48.64917 1.000 65.20000  ? 334 GLN A NE2 1 
ATOM   1366 N N   . LEU A 1 217 ? -31.21805 13.69044  -45.84653 1.000 35.97000  ? 335 LEU A N   1 
ATOM   1367 C CA  . LEU A 1 217 ? -31.92657 14.95323  -46.01592 1.000 36.72000  ? 335 LEU A CA  1 
ATOM   1368 C C   . LEU A 1 217 ? -30.96806 16.14075  -46.18304 1.000 41.31000  ? 335 LEU A C   1 
ATOM   1369 O O   . LEU A 1 217 ? -29.83214 16.13496  -45.69784 1.000 31.34000  ? 335 LEU A O   1 
ATOM   1370 C CB  . LEU A 1 217 ? -32.83389 15.18613  -44.81295 1.000 32.43000  ? 335 LEU A CB  1 
ATOM   1371 C CG  . LEU A 1 217 ? -33.96649 14.18151  -44.61375 1.000 37.00000  ? 335 LEU A CG  1 
ATOM   1372 C CD1 . LEU A 1 217 ? -34.99291 14.71048  -43.61663 1.000 37.61000  ? 335 LEU A CD1 1 
ATOM   1373 C CD2 . LEU A 1 217 ? -34.63711 13.87400  -45.93805 1.000 36.26000  ? 335 LEU A CD2 1 
ATOM   1374 N N   . HIS A 1 218 ? -31.45639 17.18394  -46.86052 1.000 46.28000  ? 336 HIS A N   1 
ATOM   1375 C CA  . HIS A 1 218 ? -30.71990 18.42936  -47.02565 1.000 36.30000  ? 336 HIS A CA  1 
ATOM   1376 C C   . HIS A 1 218 ? -30.85151 19.29356  -45.77517 1.000 37.69000  ? 336 HIS A C   1 
ATOM   1377 O O   . HIS A 1 218 ? -31.75559 19.11168  -44.95144 1.000 39.19000  ? 336 HIS A O   1 
ATOM   1378 C CB  . HIS A 1 218 ? -31.23702 19.20484  -48.23929 1.000 38.93000  ? 336 HIS A CB  1 
ATOM   1379 C CG  . HIS A 1 218 ? -31.11646 18.46666  -49.54270 1.000 48.63000  ? 336 HIS A CG  1 
ATOM   1380 N ND1 . HIS A 1 218 ? -31.79342 18.85903  -50.68460 1.000 44.71000  ? 336 HIS A ND1 1 
ATOM   1381 C CD2 . HIS A 1 218 ? -30.38891 17.37518  -49.89121 1.000 40.24000  ? 336 HIS A CD2 1 
ATOM   1382 C CE1 . HIS A 1 218 ? -31.49987 18.02874  -51.67203 1.000 44.36000  ? 336 HIS A CE1 1 
ATOM   1383 N NE2 . HIS A 1 218 ? -30.64056 17.12785  -51.22140 1.000 41.22000  ? 336 HIS A NE2 1 
ATOM   1384 N N   . GLU A 1 219 ? -29.92796 20.24788  -45.62944 1.000 39.92000  ? 337 GLU A N   1 
ATOM   1385 C CA  . GLU A 1 219 ? -30.05858 21.21119  -44.54290 1.000 36.69000  ? 337 GLU A CA  1 
ATOM   1386 C C   . GLU A 1 219 ? -31.46284 21.79456  -44.51981 1.000 39.33000  ? 337 GLU A C   1 
ATOM   1387 O O   . GLU A 1 219 ? -32.10207 21.87666  -43.45988 1.000 32.14000  ? 337 GLU A O   1 
ATOM   1388 C CB  . GLU A 1 219 ? -29.04005 22.33773  -44.70005 1.000 36.19000  ? 337 GLU A CB  1 
ATOM   1389 C CG  . GLU A 1 219 ? -27.59088 21.91832  -44.62402 1.000 38.47000  ? 337 GLU A CG  1 
ATOM   1390 C CD  . GLU A 1 219 ? -27.12897 21.54170  -43.22116 1.000 40.46000  ? 337 GLU A CD  1 
ATOM   1391 O OE1 . GLU A 1 219 ? -27.95516 21.58378  -42.27929 1.000 32.02000  ? 337 GLU A OE1 1 
ATOM   1392 O OE2 . GLU A 1 219 ? -25.92285 21.20014  -43.07714 1.000 38.41000  ? 337 GLU A OE2 1 
ATOM   1393 N N   . GLU A 1 220 ? -31.96480 22.19003  -45.69767 1.000 39.28000  ? 338 GLU A N   1 
ATOM   1394 C CA  . GLU A 1 220 ? -33.29404 22.78350  -45.78757 1.000 34.62000  ? 338 GLU A CA  1 
ATOM   1395 C C   . GLU A 1 220 ? -34.38870 21.82376  -45.34634 1.000 36.33000  ? 338 GLU A C   1 
ATOM   1396 O O   . GLU A 1 220 ? -35.40900 22.26400  -44.80327 1.000 39.60000  ? 338 GLU A O   1 
ATOM   1397 C CB  . GLU A 1 220 ? -33.54899 23.25822  -47.20934 1.000 38.72000  ? 338 GLU A CB  1 
ATOM   1398 C CG  . GLU A 1 220 ? -32.73044 24.47484  -47.63747 1.000 46.99000  ? 338 GLU A CG  1 
ATOM   1399 C CD  . GLU A 1 220 ? -31.32621 24.13672  -48.09641 1.000 46.18000  ? 338 GLU A CD  1 
ATOM   1400 O OE1 . GLU A 1 220 ? -30.95770 22.94084  -48.02105 1.000 41.20000  ? 338 GLU A OE1 1 
ATOM   1401 O OE2 . GLU A 1 220 ? -30.59554 25.07929  -48.51672 1.000 50.17000  ? 338 GLU A OE2 1 
ATOM   1402 N N   . GLU A 1 221 ? -34.21109 20.51897  -45.57107 1.000 37.64000  ? 339 GLU A N   1 
ATOM   1403 C CA  . GLU A 1 221 ? -35.24674 19.56229  -45.19082 1.000 38.52000  ? 339 GLU A CA  1 
ATOM   1404 C C   . GLU A 1 221 ? -35.27893 19.36339  -43.68395 1.000 35.26000  ? 339 GLU A C   1 
ATOM   1405 O O   . GLU A 1 221 ? -36.35203 19.32556  -43.07017 1.000 36.70000  ? 339 GLU A O   1 
ATOM   1406 C CB  . GLU A 1 221 ? -35.01103 18.23681  -45.90156 1.000 39.61000  ? 339 GLU A CB  1 
ATOM   1407 C CG  . GLU A 1 221 ? -35.64275 18.18334  -47.27371 1.000 42.18000  ? 339 GLU A CG  1 
ATOM   1408 C CD  . GLU A 1 221 ? -34.85420 17.35628  -48.27505 1.000 44.69000  ? 339 GLU A CD  1 
ATOM   1409 O OE1 . GLU A 1 221 ? -33.87297 16.67348  -47.89327 1.000 37.97000  ? 339 GLU A OE1 1 
ATOM   1410 O OE2 . GLU A 1 221 ? -35.26898 17.35179  -49.45113 1.000 47.65000  ? 339 GLU A OE2 1 
ATOM   1411 N N   . TYR A 1 222 ? -34.10600 19.25355  -43.07479 1.000 30.98000  ? 340 TYR A N   1 
ATOM   1412 C CA  . TYR A 1 222 ? -34.00124 19.20274  -41.62280 1.000 31.65000  ? 340 TYR A CA  1 
ATOM   1413 C C   . TYR A 1 222 ? -34.65390 20.42207  -40.96321 1.000 36.63000  ? 340 TYR A C   1 
ATOM   1414 O O   . TYR A 1 222 ? -35.39103 20.29217  -39.97442 1.000 35.06000  ? 340 TYR A O   1 
ATOM   1415 C CB  . TYR A 1 222 ? -32.51827 19.11318  -41.25158 1.000 36.21000  ? 340 TYR A CB  1 
ATOM   1416 C CG  . TYR A 1 222 ? -31.93666 17.70640  -41.20330 1.000 38.69000  ? 340 TYR A CG  1 
ATOM   1417 C CD1 . TYR A 1 222 ? -32.36045 16.79765  -40.23591 1.000 30.22000  ? 340 TYR A CD1 1 
ATOM   1418 C CD2 . TYR A 1 222 ? -30.94832 17.29937  -42.10936 1.000 35.26000  ? 340 TYR A CD2 1 
ATOM   1419 C CE1 . TYR A 1 222 ? -31.82091 15.54184  -40.16855 1.000 34.99000  ? 340 TYR A CE1 1 
ATOM   1420 C CE2 . TYR A 1 222 ? -30.40077 16.02457  -42.05101 1.000 29.90000  ? 340 TYR A CE2 1 
ATOM   1421 C CZ  . TYR A 1 222 ? -30.84857 15.15581  -41.08060 1.000 37.28000  ? 340 TYR A CZ  1 
ATOM   1422 O OH  . TYR A 1 222 ? -30.34003 13.88297  -40.98825 1.000 40.09000  ? 340 TYR A OH  1 
ATOM   1423 N N   . VAL A 1 223 ? -34.38233 21.62749  -41.48145 1.000 33.94000  ? 341 VAL A N   1 
ATOM   1424 C CA  . VAL A 1 223 ? -34.89397 22.79686  -40.77786 1.000 34.36000  ? 341 VAL A CA  1 
ATOM   1425 C C   . VAL A 1 223 ? -36.39698 22.90031  -40.97007 1.000 37.10000  ? 341 VAL A C   1 
ATOM   1426 O O   . VAL A 1 223 ? -37.11236 23.38848  -40.08492 1.000 40.73000  ? 341 VAL A O   1 
ATOM   1427 C CB  . VAL A 1 223 ? -34.16146 24.08943  -41.20596 1.000 38.63000  ? 341 VAL A CB  1 
ATOM   1428 C CG1 . VAL A 1 223 ? -34.63544 24.60901  -42.55474 1.000 29.43000  ? 341 VAL A CG1 1 
ATOM   1429 C CG2 . VAL A 1 223 ? -34.31712 25.14574  -40.14237 1.000 35.15000  ? 341 VAL A CG2 1 
ATOM   1430 N N   . LEU A 1 224 ? -36.91056 22.41875  -42.10245 1.000 37.62000  ? 342 LEU A N   1 
ATOM   1431 C CA  . LEU A 1 224 ? -38.35552 22.38723  -42.29174 1.000 37.90000  ? 342 LEU A CA  1 
ATOM   1432 C C   . LEU A 1 224 ? -39.00725 21.38039  -41.35345 1.000 37.79000  ? 342 LEU A C   1 
ATOM   1433 O O   . LEU A 1 224 ? -40.08447 21.64560  -40.80249 1.000 34.06000  ? 342 LEU A O   1 
ATOM   1434 C CB  . LEU A 1 224 ? -38.68111 22.06794  -43.74698 1.000 42.54000  ? 342 LEU A CB  1 
ATOM   1435 C CG  . LEU A 1 224 ? -38.63850 23.33147  -44.61623 1.000 39.96000  ? 342 LEU A CG  1 
ATOM   1436 C CD1 . LEU A 1 224 ? -38.55305 22.93137  -46.07945 1.000 35.57000  ? 342 LEU A CD1 1 
ATOM   1437 C CD2 . LEU A 1 224 ? -39.84495 24.24378  -44.33492 1.000 36.56000  ? 342 LEU A CD2 1 
ATOM   1438 N N   . MET A 1 225 ? -38.37078 20.21855  -41.14901 1.000 36.46000  ? 343 MET A N   1 
ATOM   1439 C CA  . MET A 1 225 ? -38.88558 19.32672  -40.12363 1.000 37.40000  ? 343 MET A CA  1 
ATOM   1440 C C   . MET A 1 225 ? -38.97213 20.03990  -38.78823 1.000 38.18000  ? 343 MET A C   1 
ATOM   1441 O O   . MET A 1 225 ? -39.96620 19.88705  -38.07550 1.000 41.91000  ? 343 MET A O   1 
ATOM   1442 C CB  . MET A 1 225 ? -38.05004 18.05401  -39.98323 1.000 33.14000  ? 343 MET A CB  1 
ATOM   1443 C CG  . MET A 1 225 ? -38.07643 17.14468  -41.14676 1.000 34.86000  ? 343 MET A CG  1 
ATOM   1444 S SD  . MET A 1 225 ? -36.95287 15.76002  -40.89437 1.000 42.70000  ? 343 MET A SD  1 
ATOM   1445 C CE  . MET A 1 225 ? -37.89965 14.76092  -39.72113 1.000 38.94000  ? 343 MET A CE  1 
ATOM   1446 N N   . GLN A 1 226 ? -37.95555 20.84114  -38.44257 1.000 38.96000  ? 344 GLN A N   1 
ATOM   1447 C CA  . GLN A 1 226 ? -37.98410 21.56038  -37.16715 1.000 40.88000  ? 344 GLN A CA  1 
ATOM   1448 C C   . GLN A 1 226 ? -39.22451 22.44478  -37.06386 1.000 36.54000  ? 344 GLN A C   1 
ATOM   1449 O O   . GLN A 1 226 ? -39.96067 22.39787  -36.06603 1.000 35.93000  ? 344 GLN A O   1 
ATOM   1450 C CB  . GLN A 1 226 ? -36.70449 22.38284  -36.99043 1.000 35.22000  ? 344 GLN A CB  1 
ATOM   1451 C CG  . GLN A 1 226 ? -35.43715 21.49925  -36.74672 1.000 37.05000  ? 344 GLN A CG  1 
ATOM   1452 C CD  . GLN A 1 226 ? -34.13554 22.31973  -36.58300 1.000 33.66000  ? 344 GLN A CD  1 
ATOM   1453 O OE1 . GLN A 1 226 ? -33.03329 21.79228  -36.70510 1.000 29.07000  ? 344 GLN A OE1 1 
ATOM   1454 N NE2 . GLN A 1 226 ? -34.27516 23.61251  -36.31926 1.000 32.78000  ? 344 GLN A NE2 1 
ATOM   1455 N N   . ALA A 1 227 ? -39.49866 23.23327  -38.10045 1.000 38.42000  ? 345 ALA A N   1 
ATOM   1456 C CA  . ALA A 1 227 ? -40.67105 24.10573  -38.05815 1.000 40.21000  ? 345 ALA A CA  1 
ATOM   1457 C C   . ALA A 1 227 ? -41.94373 23.29407  -37.89487 1.000 38.32000  ? 345 ALA A C   1 
ATOM   1458 O O   . ALA A 1 227 ? -42.79203 23.62921  -37.06083 1.000 43.27000  ? 345 ALA A O   1 
ATOM   1459 C CB  . ALA A 1 227 ? -40.74820 24.97543  -39.31566 1.000 34.12000  ? 345 ALA A CB  1 
ATOM   1460 N N   . ILE A 1 228 ? -42.08411 22.20447  -38.66853 1.000 36.58000  ? 346 ILE A N   1 
ATOM   1461 C CA  . ILE A 1 228 ? -43.29876 21.39389  -38.59323 1.000 36.79000  ? 346 ILE A CA  1 
ATOM   1462 C C   . ILE A 1 228 ? -43.46277 20.81300  -37.20160 1.000 40.25000  ? 346 ILE A C   1 
ATOM   1463 O O   . ILE A 1 228 ? -44.57584 20.74120  -36.66485 1.000 39.69000  ? 346 ILE A O   1 
ATOM   1464 C CB  . ILE A 1 228 ? -43.29608 20.27651  -39.64389 1.000 37.07000  ? 346 ILE A CB  1 
ATOM   1465 C CG1 . ILE A 1 228 ? -43.30907 20.85134  -41.06755 1.000 39.94000  ? 346 ILE A CG1 1 
ATOM   1466 C CG2 . ILE A 1 228 ? -44.49974 19.41285  -39.42262 1.000 28.01000  ? 346 ILE A CG2 1 
ATOM   1467 C CD1 . ILE A 1 228 ? -42.72545 19.89422  -42.12601 1.000 36.97000  ? 346 ILE A CD1 1 
ATOM   1468 N N   . SER A 1 229 ? -42.35669 20.39113  -36.59465 1.000 38.42000  ? 347 SER A N   1 
ATOM   1469 C CA  . SER A 1 229 ? -42.39875 19.93829  -35.20792 1.000 35.65000  ? 347 SER A CA  1 
ATOM   1470 C C   . SER A 1 229 ? -42.73543 21.08259  -34.25231 1.000 41.05000  ? 347 SER A C   1 
ATOM   1471 O O   . SER A 1 229 ? -43.45553 20.89069  -33.26156 1.000 35.57000  ? 347 SER A O   1 
ATOM   1472 C CB  . SER A 1 229 ? -41.05855 19.32867  -34.84103 1.000 31.10000  ? 347 SER A CB  1 
ATOM   1473 O OG  . SER A 1 229 ? -41.03465 18.98088  -33.47823 1.000 38.28000  ? 347 SER A OG  1 
ATOM   1474 N N   . LEU A 1 230 ? -42.18891 22.27098  -34.50651 1.000 43.77000  ? 348 LEU A N   1 
ATOM   1475 C CA  . LEU A 1 230 ? -42.32556 23.35235  -33.54290 1.000 40.15000  ? 348 LEU A CA  1 
ATOM   1476 C C   . LEU A 1 230 ? -43.75579 23.85470  -33.50087 1.000 41.94000  ? 348 LEU A C   1 
ATOM   1477 O O   . LEU A 1 230 ? -44.31409 24.08582  -32.41884 1.000 37.81000  ? 348 LEU A O   1 
ATOM   1478 C CB  . LEU A 1 230 ? -41.37299 24.48898  -33.89906 1.000 38.76000  ? 348 LEU A CB  1 
ATOM   1479 C CG  . LEU A 1 230 ? -41.51769 25.72039  -33.00636 1.000 38.25000  ? 348 LEU A CG  1 
ATOM   1480 C CD1 . LEU A 1 230 ? -41.20181 25.37368  -31.55651 1.000 26.74000  ? 348 LEU A CD1 1 
ATOM   1481 C CD2 . LEU A 1 230 ? -40.62708 26.82808  -33.52455 1.000 37.70000  ? 348 LEU A CD2 1 
ATOM   1482 N N   . PHE A 1 231 ? -44.35465 24.03413  -34.67588 1.000 44.58000  ? 349 PHE A N   1 
ATOM   1483 C CA  . PHE A 1 231 ? -45.72084 24.53761  -34.80883 1.000 45.37000  ? 349 PHE A CA  1 
ATOM   1484 C C   . PHE A 1 231 ? -46.71333 23.37818  -34.82370 1.000 45.96000  ? 349 PHE A C   1 
ATOM   1485 O O   . PHE A 1 231 ? -47.39904 23.12446  -35.80697 1.000 47.50000  ? 349 PHE A O   1 
ATOM   1486 C CB  . PHE A 1 231 ? -45.84698 25.38229  -36.06936 1.000 42.57000  ? 349 PHE A CB  1 
ATOM   1487 C CG  . PHE A 1 231 ? -45.01253 26.62265  -36.05048 1.000 41.54000  ? 349 PHE A CG  1 
ATOM   1488 C CD1 . PHE A 1 231 ? -45.52114 27.80012  -35.52888 1.000 43.08000  ? 349 PHE A CD1 1 
ATOM   1489 C CD2 . PHE A 1 231 ? -43.72043 26.62051  -36.55324 1.000 44.97000  ? 349 PHE A CD2 1 
ATOM   1490 C CE1 . PHE A 1 231 ? -44.75266 28.97144  -35.50705 1.000 44.42000  ? 349 PHE A CE1 1 
ATOM   1491 C CE2 . PHE A 1 231 ? -42.94095 27.79284  -36.53741 1.000 47.85000  ? 349 PHE A CE2 1 
ATOM   1492 C CZ  . PHE A 1 231 ? -43.45956 28.96630  -36.00681 1.000 42.37000  ? 349 PHE A CZ  1 
ATOM   1493 N N   . SER A 1 232 ? -46.74321 22.64252  -33.72013 1.000 43.31000  ? 350 SER A N   1 
ATOM   1494 C CA  . SER A 1 232 ? -47.69877 21.56000  -33.56095 1.000 49.01000  ? 350 SER A CA  1 
ATOM   1495 C C   . SER A 1 232 ? -48.93213 22.07603  -32.82587 1.000 57.00000  ? 350 SER A C   1 
ATOM   1496 O O   . SER A 1 232 ? -48.81653 22.49740  -31.66160 1.000 54.67000  ? 350 SER A O   1 
ATOM   1497 C CB  . SER A 1 232 ? -47.07340 20.40283  -32.80251 1.000 44.53000  ? 350 SER A CB  1 
ATOM   1498 O OG  . SER A 1 232 ? -46.28789 19.61870  -33.68883 1.000 48.28000  ? 350 SER A OG  1 
ATOM   1499 N N   . PRO A 1 233 ? -50.11900 22.04788  -33.44411 1.000 53.51000  ? 351 PRO A N   1 
ATOM   1500 C CA  . PRO A 1 233 ? -51.28741 22.72301  -32.83893 1.000 55.43000  ? 351 PRO A CA  1 
ATOM   1501 C C   . PRO A 1 233 ? -51.85834 22.03504  -31.62344 1.000 54.12000  ? 351 PRO A C   1 
ATOM   1502 O O   . PRO A 1 233 ? -52.53377 22.70228  -30.83317 1.000 60.26000  ? 351 PRO A O   1 
ATOM   1503 C CB  . PRO A 1 233 ? -52.31322 22.75523  -33.97410 1.000 55.36000  ? 351 PRO A CB  1 
ATOM   1504 C CG  . PRO A 1 233 ? -51.92056 21.63993  -34.87468 1.000 61.59000  ? 351 PRO A CG  1 
ATOM   1505 C CD  . PRO A 1 233 ? -50.42750 21.44451  -34.74952 1.000 54.48000  ? 351 PRO A CD  1 
ATOM   1506 N N   . ASP A 1 234 ? -51.60681 20.74804  -31.42415 1.000 58.97000  ? 352 ASP A N   1 
ATOM   1507 C CA  . ASP A 1 234 ? -52.21668 20.00113  -30.32870 1.000 63.80000  ? 352 ASP A CA  1 
ATOM   1508 C C   . ASP A 1 234 ? -51.18670 19.59895  -29.26874 1.000 67.18000  ? 352 ASP A C   1 
ATOM   1509 O O   . ASP A 1 234 ? -51.19931 18.48264  -28.73740 1.000 65.83000  ? 352 ASP A O   1 
ATOM   1510 C CB  . ASP A 1 234 ? -53.00806 18.81410  -30.88154 1.000 66.52000  ? 352 ASP A CB  1 
ATOM   1511 C CG  . ASP A 1 234 ? -52.22752 18.01005  -31.91087 1.000 82.22000  ? 352 ASP A CG  1 
ATOM   1512 O OD1 . ASP A 1 234 ? -51.03462 18.32971  -32.14146 1.000 79.27000  ? 352 ASP A OD1 1 
ATOM   1513 O OD2 . ASP A 1 234 ? -52.82901 17.10816  -32.54951 1.000 86.02000  ? 352 ASP A OD2 1 
ATOM   1514 N N   . ARG A 1 235 ? -50.27718 20.55216  -28.93601 1.000 59.68000  ? 353 ARG A N   1 
ATOM   1515 C CA  . ARG A 1 235 ? -49.43936 20.46483  -27.75291 1.000 52.23000  ? 353 ARG A CA  1 
ATOM   1516 C C   . ARG A 1 235 ? -50.26076 20.86075  -26.52683 1.000 55.32000  ? 353 ARG A C   1 
ATOM   1517 O O   . ARG A 1 235 ? -51.07516 21.78444  -26.60144 1.000 53.59000  ? 353 ARG A O   1 
ATOM   1518 C CB  . ARG A 1 235 ? -48.23775 21.39943  -27.87414 1.000 47.36000  ? 353 ARG A CB  1 
ATOM   1519 C CG  . ARG A 1 235 ? -47.27542 21.14053  -29.03911 1.000 51.07000  ? 353 ARG A CG  1 
ATOM   1520 C CD  . ARG A 1 235 ? -46.48988 19.84481  -28.91673 1.000 48.68000  ? 353 ARG A CD  1 
ATOM   1521 N NE  . ARG A 1 235 ? -45.40668 19.80286  -29.89756 1.000 46.58000  ? 353 ARG A NE  1 
ATOM   1522 C CZ  . ARG A 1 235 ? -44.68115 18.72135  -30.20306 1.000 43.30000  ? 353 ARG A CZ  1 
ATOM   1523 N NH1 . ARG A 1 235 ? -44.89674 17.54791  -29.60979 1.000 34.43000  ? 353 ARG A NH1 1 
ATOM   1524 N NH2 . ARG A 1 235 ? -43.71303 18.83031  -31.10581 1.000 35.55000  ? 353 ARG A NH2 1 
ATOM   1525 N N   . PRO A 1 236 ? -50.06468 20.19417  -25.39418 1.000 48.17000  ? 354 PRO A N   1 
ATOM   1526 C CA  . PRO A 1 236 ? -50.73609 20.61515  -24.16006 1.000 50.28000  ? 354 PRO A CA  1 
ATOM   1527 C C   . PRO A 1 236 ? -50.61480 22.11906  -23.90616 1.000 62.42000  ? 354 PRO A C   1 
ATOM   1528 O O   . PRO A 1 236 ? -49.51305 22.68153  -23.88662 1.000 59.31000  ? 354 PRO A O   1 
ATOM   1529 C CB  . PRO A 1 236 ? -49.99994 19.80485  -23.09140 1.000 44.84000  ? 354 PRO A CB  1 
ATOM   1530 C CG  . PRO A 1 236 ? -49.67025 18.52841  -23.80609 1.000 41.92000  ? 354 PRO A CG  1 
ATOM   1531 C CD  . PRO A 1 236 ? -49.24219 18.98940  -25.17974 1.000 44.89000  ? 354 PRO A CD  1 
ATOM   1532 N N   . GLY A 1 237 ? -51.76812 22.77944  -23.71898 1.000 56.32000  ? 355 GLY A N   1 
ATOM   1533 C CA  . GLY A 1 237 ? -51.81281 24.17319  -23.32117 1.000 41.70000  ? 355 GLY A CA  1 
ATOM   1534 C C   . GLY A 1 237 ? -51.81304 25.18585  -24.44958 1.000 54.64000  ? 355 GLY A C   1 
ATOM   1535 O O   . GLY A 1 237 ? -51.79363 26.39770  -24.17586 1.000 60.25000  ? 355 GLY A O   1 
ATOM   1536 N N   . VAL A 1 238 ? -51.82962 24.74458  -25.70584 1.000 50.26000  ? 356 VAL A N   1 
ATOM   1537 C CA  . VAL A 1 238 ? -51.89283 25.68820  -26.81130 1.000 51.47000  ? 356 VAL A CA  1 
ATOM   1538 C C   . VAL A 1 238 ? -53.30105 26.24664  -26.91223 1.000 61.82000  ? 356 VAL A C   1 
ATOM   1539 O O   . VAL A 1 238 ? -54.28974 25.50318  -26.85385 1.000 67.34000  ? 356 VAL A O   1 
ATOM   1540 C CB  . VAL A 1 238 ? -51.46529 25.02116  -28.12661 1.000 54.85000  ? 356 VAL A CB  1 
ATOM   1541 C CG1 . VAL A 1 238 ? -51.44454 26.05583  -29.24800 1.000 56.43000  ? 356 VAL A CG1 1 
ATOM   1542 C CG2 . VAL A 1 238 ? -50.09005 24.41768  -27.97871 1.000 57.51000  ? 356 VAL A CG2 1 
ATOM   1543 N N   . LEU A 1 239 ? -53.40160 27.56070  -27.07647 1.000 62.10000  ? 357 LEU A N   1 
ATOM   1544 C CA  . LEU A 1 239 ? -54.69486 28.21321  -27.20633 1.000 60.08000  ? 357 LEU A CA  1 
ATOM   1545 C C   . LEU A 1 239 ? -55.08470 28.45589  -28.65826 1.000 62.89000  ? 357 LEU A C   1 
ATOM   1546 O O   . LEU A 1 239 ? -56.18046 28.07765  -29.07568 1.000 69.52000  ? 357 LEU A O   1 
ATOM   1547 C CB  . LEU A 1 239 ? -54.68158 29.52475  -26.41756 1.000 60.79000  ? 357 LEU A CB  1 
ATOM   1548 C CG  . LEU A 1 239 ? -54.55375 29.26892  -24.90668 1.000 65.56000  ? 357 LEU A CG  1 
ATOM   1549 C CD1 . LEU A 1 239 ? -54.78945 30.54035  -24.11598 1.000 63.03000  ? 357 LEU A CD1 1 
ATOM   1550 C CD2 . LEU A 1 239 ? -55.49634 28.13922  -24.41952 1.000 52.38000  ? 357 LEU A CD2 1 
ATOM   1551 N N   . GLN A 1 240 ? -54.19781 29.05174  -29.44475 1.000 55.08000  ? 358 GLN A N   1 
ATOM   1552 C CA  . GLN A 1 240 ? -54.46669 29.36045  -30.84661 1.000 52.13000  ? 358 GLN A CA  1 
ATOM   1553 C C   . GLN A 1 240 ? -54.28798 28.13206  -31.75530 1.000 56.05000  ? 358 GLN A C   1 
ATOM   1554 O O   . GLN A 1 240 ? -53.44481 28.11096  -32.65616 1.000 55.70000  ? 358 GLN A O   1 
ATOM   1555 C CB  . GLN A 1 240 ? -53.55110 30.49211  -31.29078 1.000 54.87000  ? 358 GLN A CB  1 
ATOM   1556 C CG  . GLN A 1 240 ? -53.58479 31.66455  -30.37210 1.000 56.88000  ? 358 GLN A CG  1 
ATOM   1557 C CD  . GLN A 1 240 ? -54.53917 32.72642  -30.84765 1.000 71.21000  ? 358 GLN A CD  1 
ATOM   1558 O OE1 . GLN A 1 240 ? -55.63995 32.42521  -31.31503 1.000 79.45000  ? 358 GLN A OE1 1 
ATOM   1559 N NE2 . GLN A 1 240 ? -54.12674 33.98353  -30.73484 1.000 79.00000  ? 358 GLN A NE2 1 
ATOM   1560 N N   . HIS A 1 241 ? -55.10857 27.10057  -31.53406 1.000 53.85000  ? 359 HIS A N   1 
ATOM   1561 C CA  A HIS A 1 241 ? -55.01990 25.91110  -32.37074 0.500 53.43000  ? 359 HIS A CA  1 
ATOM   1562 C CA  B HIS A 1 241 ? -55.05989 25.90408  -32.37775 0.500 52.91000  ? 359 HIS A CA  1 
ATOM   1563 C C   . HIS A 1 241 ? -55.15278 26.26791  -33.85056 1.000 55.71000  ? 359 HIS A C   1 
ATOM   1564 O O   . HIS A 1 241 ? -54.32744 25.84875  -34.66865 1.000 54.94000  ? 359 HIS A O   1 
ATOM   1565 C CB  A HIS A 1 241 ? -56.06952 24.87938  -31.94054 0.500 53.92000  ? 359 HIS A CB  1 
ATOM   1566 C CB  B HIS A 1 241 ? -56.19654 24.94537  -32.00753 0.500 53.98000  ? 359 HIS A CB  1 
ATOM   1567 C CG  A HIS A 1 241 ? -55.86955 24.34465  -30.54882 0.500 55.69000  ? 359 HIS A CG  1 
ATOM   1568 C CG  B HIS A 1 241 ? -56.13283 23.61380  -32.69930 0.500 55.63000  ? 359 HIS A CG  1 
ATOM   1569 N ND1 A HIS A 1 241 ? -54.92618 23.38589  -30.24521 0.500 56.32000  ? 359 HIS A ND1 1 
ATOM   1570 N ND1 B HIS A 1 241 ? -55.22146 22.63401  -32.36571 0.500 57.63000  ? 359 HIS A ND1 1 
ATOM   1571 C CD2 A HIS A 1 241 ? -56.50089 24.62569  -29.38277 0.500 56.98000  ? 359 HIS A CD2 1 
ATOM   1572 C CD2 B HIS A 1 241 ? -56.86142 23.11209  -33.72573 0.500 55.40000  ? 359 HIS A CD2 1 
ATOM   1573 C CE1 A HIS A 1 241 ? -54.98030 23.10211  -28.95539 0.500 54.57000  ? 359 HIS A CE1 1 
ATOM   1574 C CE1 B HIS A 1 241 ? -55.40586 21.57938  -33.14036 0.500 57.77000  ? 359 HIS A CE1 1 
ATOM   1575 N NE2 A HIS A 1 241 ? -55.92672 23.84237  -28.40813 0.500 55.56000  ? 359 HIS A NE2 1 
ATOM   1576 N NE2 B HIS A 1 241 ? -56.39182 21.84644  -33.97938 0.500 57.65000  ? 359 HIS A NE2 1 
ATOM   1577 N N   . ARG A 1 242 ? -56.16306 27.06668  -34.20928 1.000 61.22000  ? 360 ARG A N   1 
ATOM   1578 C CA  . ARG A 1 242 ? -56.39194 27.38340  -35.61913 1.000 65.02000  ? 360 ARG A CA  1 
ATOM   1579 C C   . ARG A 1 242 ? -55.15910 28.01132  -36.25954 1.000 60.73000  ? 360 ARG A C   1 
ATOM   1580 O O   . ARG A 1 242 ? -54.74972 27.62315  -37.36069 1.000 64.84000  ? 360 ARG A O   1 
ATOM   1581 C CB  . ARG A 1 242 ? -57.60032 28.31296  -35.77081 1.000 70.49000  ? 360 ARG A CB  1 
ATOM   1582 C CG  . ARG A 1 242 ? -58.05614 28.50661  -37.21778 1.000 58.67000  ? 360 ARG A CG  1 
ATOM   1583 N N   . VAL A 1 243 ? -54.55865 28.99019  -35.58685 1.000 53.05000  ? 361 VAL A N   1 
ATOM   1584 C CA  . VAL A 1 243 ? -53.42986 29.70903  -36.17122 1.000 54.68000  ? 361 VAL A CA  1 
ATOM   1585 C C   . VAL A 1 243 ? -52.21443 28.79265  -36.32453 1.000 56.91000  ? 361 VAL A C   1 
ATOM   1586 O O   . VAL A 1 243 ? -51.54124 28.79256  -37.36441 1.000 50.36000  ? 361 VAL A O   1 
ATOM   1587 C CB  . VAL A 1 243 ? -53.10756 30.95267  -35.32443 1.000 54.00000  ? 361 VAL A CB  1 
ATOM   1588 C CG1 . VAL A 1 243 ? -51.84776 31.62052  -35.83280 1.000 49.75000  ? 361 VAL A CG1 1 
ATOM   1589 C CG2 . VAL A 1 243 ? -54.26197 31.92822  -35.41207 1.000 51.31000  ? 361 VAL A CG2 1 
ATOM   1590 N N   . VAL A 1 244 ? -51.90927 28.00518  -35.28894 1.000 54.96000  ? 362 VAL A N   1 
ATOM   1591 C CA  . VAL A 1 244 ? -50.73389 27.14172  -35.33823 1.000 51.67000  ? 362 VAL A CA  1 
ATOM   1592 C C   . VAL A 1 244 ? -50.91622 26.05225  -36.38290 1.000 54.23000  ? 362 VAL A C   1 
ATOM   1593 O O   . VAL A 1 244 ? -49.97093 25.69009  -37.09494 1.000 51.51000  ? 362 VAL A O   1 
ATOM   1594 C CB  . VAL A 1 244 ? -50.44289 26.55903  -33.94452 1.000 50.73000  ? 362 VAL A CB  1 
ATOM   1595 C CG1 . VAL A 1 244 ? -49.31344 25.56257  -34.01789 1.000 51.52000  ? 362 VAL A CG1 1 
ATOM   1596 C CG2 . VAL A 1 244 ? -50.04555 27.67565  -33.00179 1.000 45.72000  ? 362 VAL A CG2 1 
ATOM   1597 N N   . ASP A 1 245 ? -52.13096 25.51479  -36.49244 1.000 60.06000  ? 363 ASP A N   1 
ATOM   1598 C CA  . ASP A 1 245 ? -52.41334 24.52227  -37.52108 1.000 54.84000  ? 363 ASP A CA  1 
ATOM   1599 C C   . ASP A 1 245 ? -52.21034 25.12217  -38.90769 1.000 49.72000  ? 363 ASP A C   1 
ATOM   1600 O O   . ASP A 1 245 ? -51.63790 24.48394  -39.79796 1.000 51.95000  ? 363 ASP A O   1 
ATOM   1601 C CB  . ASP A 1 245 ? -53.84213 23.98954  -37.34866 1.000 54.48000  ? 363 ASP A CB  1 
ATOM   1602 C CG  . ASP A 1 245 ? -54.17947 22.87996  -38.32037 1.000 60.57000  ? 363 ASP A CG  1 
ATOM   1603 O OD1 . ASP A 1 245 ? -53.52401 21.81522  -38.27087 1.000 67.63000  ? 363 ASP A OD1 1 
ATOM   1604 O OD2 . ASP A 1 245 ? -55.06940 23.09007  -39.17241 1.000 64.86000  ? 363 ASP A OD2 1 
ATOM   1605 N N   . GLN A 1 246 ? -52.64985 26.35909  -39.10704 1.000 55.48000  ? 364 GLN A N   1 
ATOM   1606 C CA  . GLN A 1 246 ? -52.48187 26.96294  -40.42166 1.000 59.06000  ? 364 GLN A CA  1 
ATOM   1607 C C   . GLN A 1 246 ? -51.00188 27.12078  -40.74229 1.000 52.51000  ? 364 GLN A C   1 
ATOM   1608 O O   . GLN A 1 246 ? -50.56255 26.84463  -41.87037 1.000 51.17000  ? 364 GLN A O   1 
ATOM   1609 C CB  . GLN A 1 246 ? -53.22144 28.30465  -40.48701 1.000 64.48000  ? 364 GLN A CB  1 
ATOM   1610 C CG  . GLN A 1 246 ? -54.72033 28.19319  -40.81835 1.000 61.08000  ? 364 GLN A CG  1 
ATOM   1611 N N   . LEU A 1 247 ? -50.20824 27.51454  -39.74191 1.000 51.62000  ? 365 LEU A N   1 
ATOM   1612 C CA  . LEU A 1 247 ? -48.77128 27.69829  -39.95254 1.000 52.34000  ? 365 LEU A CA  1 
ATOM   1613 C C   . LEU A 1 247 ? -48.08064 26.36576  -40.23320 1.000 49.84000  ? 365 LEU A C   1 
ATOM   1614 O O   . LEU A 1 247 ? -47.27342 26.25866  -41.17311 1.000 41.99000  ? 365 LEU A O   1 
ATOM   1615 C CB  . LEU A 1 247 ? -48.14980 28.37785  -38.73503 1.000 47.34000  ? 365 LEU A CB  1 
ATOM   1616 C CG  . LEU A 1 247 ? -48.44049 29.86861  -38.54720 1.000 45.10000  ? 365 LEU A CG  1 
ATOM   1617 C CD1 . LEU A 1 247 ? -48.20192 30.24386  -37.09894 1.000 43.51000  ? 365 LEU A CD1 1 
ATOM   1618 C CD2 . LEU A 1 247 ? -47.60869 30.72252  -39.46555 1.000 36.85000  ? 365 LEU A CD2 1 
ATOM   1619 N N   . GLN A 1 248 ? -48.40134 25.33815  -39.43886 1.000 41.08000  ? 366 GLN A N   1 
ATOM   1620 C CA  . GLN A 1 248 ? -47.83071 24.01954  -39.68153 1.000 48.71000  ? 366 GLN A CA  1 
ATOM   1621 C C   . GLN A 1 248 ? -48.11025 23.56826  -41.10284 1.000 52.84000  ? 366 GLN A C   1 
ATOM   1622 O O   . GLN A 1 248 ? -47.18795 23.17609  -41.83090 1.000 55.23000  ? 366 GLN A O   1 
ATOM   1623 C CB  . GLN A 1 248 ? -48.36945 22.98772  -38.68323 1.000 42.23000  ? 366 GLN A CB  1 
ATOM   1624 C CG  . GLN A 1 248 ? -47.55089 21.68906  -38.64484 1.000 41.19000  ? 366 GLN A CG  1 
ATOM   1625 C CD  . GLN A 1 248 ? -48.19255 20.57128  -37.79962 1.000 49.13000  ? 366 GLN A CD  1 
ATOM   1626 O OE1 . GLN A 1 248 ? -49.41548 20.39173  -37.78095 1.000 52.71000  ? 366 GLN A OE1 1 
ATOM   1627 N NE2 . GLN A 1 248 ? -47.35836 19.83522  -37.07990 1.000 48.74000  ? 366 GLN A NE2 1 
ATOM   1628 N N   . GLU A 1 249 ? -49.38220 23.62294  -41.52305 1.000 49.11000  ? 367 GLU A N   1 
ATOM   1629 C CA  . GLU A 1 249 ? -49.71075 23.15259  -42.86138 1.000 46.24000  ? 367 GLU A CA  1 
ATOM   1630 C C   . GLU A 1 249 ? -48.93391 23.95854  -43.89877 1.000 47.25000  ? 367 GLU A C   1 
ATOM   1631 O O   . GLU A 1 249 ? -48.40448 23.39634  -44.86800 1.000 45.32000  ? 367 GLU A O   1 
ATOM   1632 C CB  . GLU A 1 249 ? -51.22873 23.21305  -43.08063 1.000 49.26000  ? 367 GLU A CB  1 
ATOM   1633 C CG  . GLU A 1 249 ? -51.68936 22.97569  -44.52085 1.000 60.43000  ? 367 GLU A CG  1 
ATOM   1634 C CD  . GLU A 1 249 ? -53.20527 22.82711  -44.65622 1.000 76.47000  ? 367 GLU A CD  1 
ATOM   1635 O OE1 . GLU A 1 249 ? -53.87638 22.64320  -43.61845 1.000 87.07000  ? 367 GLU A OE1 1 
ATOM   1636 O OE2 . GLU A 1 249 ? -53.72610 22.91455  -45.79727 1.000 75.13000  ? 367 GLU A OE2 1 
ATOM   1637 N N   . GLN A 1 250 ? -48.78152 25.26647  -43.66397 1.000 46.20000  ? 368 GLN A N   1 
ATOM   1638 C CA  . GLN A 1 250 ? -47.99172 26.08735  -44.57634 1.000 46.16000  ? 368 GLN A CA  1 
ATOM   1639 C C   . GLN A 1 250 ? -46.56047 25.57104  -44.67938 1.000 47.01000  ? 368 GLN A C   1 
ATOM   1640 O O   . GLN A 1 250 ? -45.98726 25.54593  -45.77829 1.000 43.15000  ? 368 GLN A O   1 
ATOM   1641 C CB  . GLN A 1 250 ? -48.02344 27.55407  -44.13149 1.000 48.19000  ? 368 GLN A CB  1 
ATOM   1642 N N   . PHE A 1 251 ? -45.97848 25.12063  -43.55054 1.000 41.65000  ? 369 PHE A N   1 
ATOM   1643 C CA  . PHE A 1 251 ? -44.61525 24.59024  -43.56960 1.000 35.06000  ? 369 PHE A CA  1 
ATOM   1644 C C   . PHE A 1 251 ? -44.55552 23.22266  -44.24639 1.000 41.96000  ? 369 PHE A C   1 
ATOM   1645 O O   . PHE A 1 251 ? -43.64126 22.95853  -45.04038 1.000 42.20000  ? 369 PHE A O   1 
ATOM   1646 C CB  . PHE A 1 251 ? -44.04947 24.51065  -42.14754 1.000 42.13000  ? 369 PHE A CB  1 
ATOM   1647 C CG  . PHE A 1 251 ? -43.58015 25.83253  -41.59768 1.000 30.63000  ? 369 PHE A CG  1 
ATOM   1648 C CD1 . PHE A 1 251 ? -42.52434 26.50533  -42.17609 1.000 34.17000  ? 369 PHE A CD1 1 
ATOM   1649 C CD2 . PHE A 1 251 ? -44.19761 26.40062  -40.50646 1.000 38.42000  ? 369 PHE A CD2 1 
ATOM   1650 C CE1 . PHE A 1 251 ? -42.09597 27.73223  -41.67229 1.000 37.08000  ? 369 PHE A CE1 1 
ATOM   1651 C CE2 . PHE A 1 251 ? -43.78024 27.63951  -40.00365 1.000 35.11000  ? 369 PHE A CE2 1 
ATOM   1652 C CZ  . PHE A 1 251 ? -42.72942 28.30032  -40.59507 1.000 31.41000  ? 369 PHE A CZ  1 
ATOM   1653 N N   . ALA A 1 252 ? -45.52319 22.34007  -43.96209 1.000 43.54000  ? 370 ALA A N   1 
ATOM   1654 C CA  . ALA A 1 252 ? -45.54049 21.03245  -44.61886 1.000 39.69000  ? 370 ALA A CA  1 
ATOM   1655 C C   . ALA A 1 252 ? -45.65327 21.16729  -46.13680 1.000 43.79000  ? 370 ALA A C   1 
ATOM   1656 O O   . ALA A 1 252 ? -44.97482 20.45303  -46.88710 1.000 39.27000  ? 370 ALA A O   1 
ATOM   1657 C CB  . ALA A 1 252 ? -46.68322 20.18562  -44.07257 1.000 38.80000  ? 370 ALA A CB  1 
ATOM   1658 N N   . ILE A 1 253 ? -46.49858 22.08020  -46.61342 1.000 42.05000  ? 371 ILE A N   1 
ATOM   1659 C CA  . ILE A 1 253 ? -46.60740 22.27200  -48.05533 1.000 43.40000  ? 371 ILE A CA  1 
ATOM   1660 C C   . ILE A 1 253 ? -45.26949 22.73193  -48.63781 1.000 44.93000  ? 371 ILE A C   1 
ATOM   1661 O O   . ILE A 1 253 ? -44.86610 22.29674  -49.72499 1.000 49.10000  ? 371 ILE A O   1 
ATOM   1662 C CB  . ILE A 1 253 ? -47.74777 23.25569  -48.37596 1.000 42.81000  ? 371 ILE A CB  1 
ATOM   1663 C CG1 . ILE A 1 253 ? -49.10554 22.61593  -48.10959 1.000 42.76000  ? 371 ILE A CG1 1 
ATOM   1664 C CG2 . ILE A 1 253 ? -47.67571 23.70856  -49.80168 1.000 40.62000  ? 371 ILE A CG2 1 
ATOM   1665 C CD1 . ILE A 1 253 ? -50.17207 23.64021  -47.67018 1.000 42.99000  ? 371 ILE A CD1 1 
ATOM   1666 N N   . THR A 1 254 ? -44.55601 23.60982  -47.92617 1.000 44.24000  ? 372 THR A N   1 
ATOM   1667 C CA  . THR A 1 254 ? -43.25912 24.07768  -48.41565 1.000 41.06000  ? 372 THR A CA  1 
ATOM   1668 C C   . THR A 1 254 ? -42.25861 22.93415  -48.47614 1.000 42.80000  ? 372 THR A C   1 
ATOM   1669 O O   . THR A 1 254 ? -41.49938 22.80705  -49.44607 1.000 43.25000  ? 372 THR A O   1 
ATOM   1670 C CB  . THR A 1 254 ? -42.72278 25.20939  -47.52289 1.000 48.54000  ? 372 THR A CB  1 
ATOM   1671 O OG1 . THR A 1 254 ? -43.60927 26.33603  -47.57439 1.000 42.82000  ? 372 THR A OG1 1 
ATOM   1672 C CG2 . THR A 1 254 ? -41.32190 25.65026  -47.96337 1.000 48.05000  ? 372 THR A CG2 1 
ATOM   1673 N N   . LEU A 1 255 ? -42.24743 22.08355  -47.45064 1.000 40.46000  ? 373 LEU A N   1 
ATOM   1674 C CA  . LEU A 1 255 ? -41.42189 20.88395  -47.51219 1.000 41.77000  ? 373 LEU A CA  1 
ATOM   1675 C C   . LEU A 1 255 ? -41.86028 19.97043  -48.65481 1.000 41.31000  ? 373 LEU A C   1 
ATOM   1676 O O   . LEU A 1 255 ? -41.01992 19.45924  -49.40795 1.000 40.99000  ? 373 LEU A O   1 
ATOM   1677 C CB  . LEU A 1 255 ? -41.46582 20.15014  -46.16763 1.000 40.41000  ? 373 LEU A CB  1 
ATOM   1678 C CG  . LEU A 1 255 ? -40.71424 18.81745  -46.12427 1.000 43.47000  ? 373 LEU A CG  1 
ATOM   1679 C CD1 . LEU A 1 255 ? -39.23724 18.99334  -46.54589 1.000 32.31000  ? 373 LEU A CD1 1 
ATOM   1680 C CD2 . LEU A 1 255 ? -40.82723 18.20558  -44.73365 1.000 37.82000  ? 373 LEU A CD2 1 
ATOM   1681 N N   . LYS A 1 256 ? -43.17316 19.76494  -48.80917 1.000 44.48000  ? 374 LYS A N   1 
ATOM   1682 C CA  . LYS A 1 256 ? -43.66859 18.92336  -49.89175 1.000 39.86000  ? 374 LYS A CA  1 
ATOM   1683 C C   . LYS A 1 256 ? -43.29159 19.49033  -51.24835 1.000 43.73000  ? 374 LYS A C   1 
ATOM   1684 O O   . LYS A 1 256 ? -42.88110 18.74703  -52.14771 1.000 45.31000  ? 374 LYS A O   1 
ATOM   1685 C CB  . LYS A 1 256 ? -45.17655 18.77464  -49.78512 1.000 46.10000  ? 374 LYS A CB  1 
ATOM   1686 C CG  . LYS A 1 256 ? -45.81195 17.85297  -50.81578 1.000 47.46000  ? 374 LYS A CG  1 
ATOM   1687 C CD  . LYS A 1 256 ? -47.32900 17.89420  -50.63704 1.000 48.85000  ? 374 LYS A CD  1 
ATOM   1688 C CE  . LYS A 1 256 ? -48.04139 16.83536  -51.44679 1.000 48.52000  ? 374 LYS A CE  1 
ATOM   1689 N NZ  . LYS A 1 256 ? -49.40838 16.58944  -50.89519 1.000 60.21000  ? 374 LYS A NZ  1 
ATOM   1690 N N   . SER A 1 257 ? -43.40614 20.80637  -51.41460 1.000 41.77000  ? 375 SER A N   1 
ATOM   1691 C CA  . SER A 1 257 ? -43.07315 21.39028  -52.70520 1.000 42.34000  ? 375 SER A CA  1 
ATOM   1692 C C   . SER A 1 257 ? -41.56916 21.50006  -52.90885 1.000 50.21000  ? 375 SER A C   1 
ATOM   1693 O O   . SER A 1 257 ? -41.09890 21.37493  -54.04784 1.000 48.26000  ? 375 SER A O   1 
ATOM   1694 C CB  . SER A 1 257 ? -43.74372 22.74807  -52.85152 1.000 46.32000  ? 375 SER A CB  1 
ATOM   1695 O OG  . SER A 1 257 ? -45.13074 22.66128  -52.54983 1.000 47.12000  ? 375 SER A OG  1 
ATOM   1696 N N   . TYR A 1 258 ? -40.80445 21.70475  -51.82459 1.000 45.56000  ? 376 TYR A N   1 
ATOM   1697 C CA  . TYR A 1 258 ? -39.34441 21.63945  -51.91736 1.000 42.61000  ? 376 TYR A CA  1 
ATOM   1698 C C   . TYR A 1 258 ? -38.88472 20.29197  -52.45807 1.000 48.49000  ? 376 TYR A C   1 
ATOM   1699 O O   . TYR A 1 258 ? -37.94554 20.22485  -53.26093 1.000 52.82000  ? 376 TYR A O   1 
ATOM   1700 C CB  . TYR A 1 258 ? -38.69677 21.89793  -50.54809 1.000 46.18000  ? 376 TYR A CB  1 
ATOM   1701 C CG  . TYR A 1 258 ? -37.17772 21.77560  -50.56388 1.000 46.41000  ? 376 TYR A CG  1 
ATOM   1702 C CD1 . TYR A 1 258 ? -36.37814 22.87413  -50.86009 1.000 43.06000  ? 376 TYR A CD1 1 
ATOM   1703 C CD2 . TYR A 1 258 ? -36.54923 20.56173  -50.30448 1.000 40.86000  ? 376 TYR A CD2 1 
ATOM   1704 C CE1 . TYR A 1 258 ? -34.99809 22.77275  -50.89389 1.000 37.13000  ? 376 TYR A CE1 1 
ATOM   1705 C CE2 . TYR A 1 258 ? -35.17218 20.44535  -50.33729 1.000 44.95000  ? 376 TYR A CE2 1 
ATOM   1706 C CZ  . TYR A 1 258 ? -34.39761 21.55587  -50.63650 1.000 49.58000  ? 376 TYR A CZ  1 
ATOM   1707 O OH  . TYR A 1 258 ? -33.02155 21.44449  -50.67931 1.000 47.73000  ? 376 TYR A OH  1 
ATOM   1708 N N   . ILE A 1 259 ? -39.52132 19.20443  -52.01882 1.000 43.48000  ? 377 ILE A N   1 
ATOM   1709 C CA  . ILE A 1 259 ? -39.09366 17.87787  -52.44752 1.000 43.91000  ? 377 ILE A CA  1 
ATOM   1710 C C   . ILE A 1 259 ? -39.47028 17.62856  -53.90774 1.000 47.90000  ? 377 ILE A C   1 
ATOM   1711 O O   . ILE A 1 259 ? -38.61995 17.22141  -54.70982 1.000 48.91000  ? 377 ILE A O   1 
ATOM   1712 C CB  . ILE A 1 259 ? -39.67737 16.81106  -51.51126 1.000 44.98000  ? 377 ILE A CB  1 
ATOM   1713 C CG1 . ILE A 1 259 ? -39.05569 16.95852  -50.11806 1.000 39.56000  ? 377 ILE A CG1 1 
ATOM   1714 C CG2 . ILE A 1 259 ? -39.46065 15.42049  -52.08204 1.000 41.31000  ? 377 ILE A CG2 1 
ATOM   1715 C CD1 . ILE A 1 259 ? -39.70650 16.08562  -49.07169 1.000 44.21000  ? 377 ILE A CD1 1 
ATOM   1716 N N   . GLU A 1 260 ? -40.74532 17.86722  -54.26984 1.000 47.58000  ? 378 GLU A N   1 
ATOM   1717 C CA  A GLU A 1 260 ? -41.20102 17.76383  -55.66198 1.000 48.96000  ? 378 GLU A CA  1 
ATOM   1718 C C   . GLU A 1 260 ? -40.20611 18.37784  -56.63344 1.000 53.53000  ? 378 GLU A C   1 
ATOM   1719 O O   . GLU A 1 260 ? -39.82665 17.77060  -57.64172 1.000 56.87000  ? 378 GLU A O   1 
ATOM   1720 C CB  A GLU A 1 260 ? -42.53330 18.48737  -55.86580 1.000 50.85000  ? 378 GLU A CB  1 
ATOM   1721 C CG  A GLU A 1 260 ? -43.81411 17.86052  -55.37241 1.000 51.15000  ? 378 GLU A CG  1 
ATOM   1722 C CD  A GLU A 1 260 ? -44.94957 18.90303  -55.39100 1.000 73.14000  ? 378 GLU A CD  1 
ATOM   1723 O OE1 A GLU A 1 260 ? -45.99260 18.69517  -54.69832 1.000 66.86000  ? 378 GLU A OE1 1 
ATOM   1724 O OE2 A GLU A 1 260 ? -44.77789 19.93753  -56.11036 1.000 67.15000  ? 378 GLU A OE2 1 
ATOM   1725 N N   . CYS A 1 261 ? -39.77669 19.59486  -56.33664 1.000 52.10000  ? 379 CYS A N   1 
ATOM   1726 C CA  . CYS A 1 261 ? -39.08188 20.42073  -57.30503 1.000 58.86000  ? 379 CYS A CA  1 
ATOM   1727 C C   . CYS A 1 261 ? -37.56488 20.37432  -57.17978 1.000 55.83000  ? 379 CYS A C   1 
ATOM   1728 O O   . CYS A 1 261 ? -36.88097 20.94812  -58.03131 1.000 58.97000  ? 379 CYS A O   1 
ATOM   1729 C CB  . CYS A 1 261 ? -39.58453 21.86244  -57.19027 1.000 57.43000  ? 379 CYS A CB  1 
ATOM   1730 N N   . ASN A 1 262 ? -37.01577 19.69296  -56.16507 1.000 57.25000  ? 380 ASN A N   1 
ATOM   1731 C CA  . ASN A 1 262 ? -35.56577 19.61650  -55.98985 1.000 54.44000  ? 380 ASN A CA  1 
ATOM   1732 C C   . ASN A 1 262 ? -35.03116 18.19969  -55.91859 1.000 59.17000  ? 380 ASN A C   1 
ATOM   1733 O O   . ASN A 1 262 ? -33.86415 18.01899  -55.55748 1.000 67.98000  ? 380 ASN A O   1 
ATOM   1734 C CB  . ASN A 1 262 ? -35.10833 20.36696  -54.73533 1.000 58.84000  ? 380 ASN A CB  1 
ATOM   1735 C CG  . ASN A 1 262 ? -35.09995 21.86208  -54.93045 1.000 63.43000  ? 380 ASN A CG  1 
ATOM   1736 O OD1 . ASN A 1 262 ? -36.09329 22.53749  -54.66423 1.000 69.15000  ? 380 ASN A OD1 1 
ATOM   1737 N ND2 . ASN A 1 262 ? -33.99008 22.38587  -55.44093 1.000 67.91000  ? 380 ASN A ND2 1 
ATOM   1738 N N   . ARG A 1 263 ? -35.87667 17.22252  -56.26232 1.000 60.97000  ? 381 ARG A N   1 
ATOM   1739 C CA  . ARG A 1 263 ? -35.48604 15.78768  -56.24609 1.000 61.91000  ? 381 ARG A CA  1 
ATOM   1740 C C   . ARG A 1 263 ? -35.94451 15.13125  -57.55356 1.000 70.10000  ? 381 ARG A C   1 
ATOM   1741 O O   . ARG A 1 263 ? -37.03058 15.49406  -58.04654 1.000 64.92000  ? 381 ARG A O   1 
ATOM   1742 C CB  . ARG A 1 263 ? -36.09696 15.08070  -55.03261 1.000 60.46000  ? 381 ARG A CB  1 
ATOM   1743 C CG  . ARG A 1 263 ? -35.54741 15.55516  -53.69423 1.000 58.46000  ? 381 ARG A CG  1 
ATOM   1744 C CD  . ARG A 1 263 ? -35.63914 14.48748  -52.62088 1.000 54.50000  ? 381 ARG A CD  1 
ATOM   1745 N NE  . ARG A 1 263 ? -34.95254 14.87207  -51.39552 1.000 46.44000  ? 381 ARG A NE  1 
ATOM   1746 C CZ  . ARG A 1 263 ? -33.73842 14.45640  -51.05254 1.000 49.20000  ? 381 ARG A CZ  1 
ATOM   1747 N NH1 . ARG A 1 263 ? -33.06891 13.63816  -51.84590 1.000 47.09000  ? 381 ARG A NH1 1 
ATOM   1748 N NH2 . ARG A 1 263 ? -33.19681 14.86197  -49.91721 1.000 50.50000  ? 381 ARG A NH2 1 
ATOM   1749 N N   . PRO A 1 264 ? -35.16999 14.18793  -58.13497 1.000 76.24000  ? 382 PRO A N   1 
ATOM   1750 C CA  . PRO A 1 264 ? -35.55747 13.52949  -59.38743 1.000 74.81000  ? 382 PRO A CA  1 
ATOM   1751 C C   . PRO A 1 264 ? -36.71008 12.53686  -59.16722 1.000 71.26000  ? 382 PRO A C   1 
ATOM   1752 O O   . PRO A 1 264 ? -36.48173 11.50261  -58.56879 1.000 76.98000  ? 382 PRO A O   1 
ATOM   1753 C CB  . PRO A 1 264 ? -34.28307 12.77729  -59.79763 1.000 65.61000  ? 382 PRO A CB  1 
ATOM   1754 C CG  . PRO A 1 264 ? -33.58718 12.49483  -58.48567 1.000 68.27000  ? 382 PRO A CG  1 
ATOM   1755 C CD  . PRO A 1 264 ? -33.88787 13.70119  -57.62002 1.000 63.37000  ? 382 PRO A CD  1 
ATOM   1756 N N   . GLN A 1 265 ? -37.90614 12.88062  -59.65524 1.000 70.37000  ? 383 GLN A N   1 
ATOM   1757 C CA  . GLN A 1 265 ? -39.10078 12.00501  -59.50798 1.000 74.42000  ? 383 GLN A CA  1 
ATOM   1758 C C   . GLN A 1 265 ? -39.00809 10.85064  -60.51164 1.000 83.06000  ? 383 GLN A C   1 
ATOM   1759 O O   . GLN A 1 265 ? -38.28497 10.99955  -61.51742 1.000 88.39000  ? 383 GLN A O   1 
ATOM   1760 C CB  . GLN A 1 265 ? -40.38210 12.81457  -59.71674 1.000 75.32000  ? 383 GLN A CB  1 
ATOM   1761 N N   . PRO A 1 266 ? -39.70363 9.71221   -60.28744 1.000 89.87000  ? 384 PRO A N   1 
ATOM   1762 C CA  . PRO A 1 266 ? -40.45676 9.48115   -59.05271 1.000 79.85000  ? 384 PRO A CA  1 
ATOM   1763 C C   . PRO A 1 266 ? -39.63763 8.73188   -57.99100 1.000 73.19000  ? 384 PRO A C   1 
ATOM   1764 O O   . PRO A 1 266 ? -40.22746 8.02216   -57.19652 1.000 75.78000  ? 384 PRO A O   1 
ATOM   1765 C CB  . PRO A 1 266 ? -41.58227 8.57195   -59.55945 1.000 68.90000  ? 384 PRO A CB  1 
ATOM   1766 C CG  . PRO A 1 266 ? -40.90370 7.70986   -60.60283 1.000 73.08000  ? 384 PRO A CG  1 
ATOM   1767 C CD  . PRO A 1 266 ? -39.83497 8.59070   -61.22112 1.000 76.09000  ? 384 PRO A CD  1 
ATOM   1768 N N   . ALA A 1 267 ? -38.31170 8.90647   -58.00565 1.000 66.96000  ? 385 ALA A N   1 
ATOM   1769 C CA  . ALA A 1 267 ? -37.42159 8.23329   -57.03088 1.000 68.59000  ? 385 ALA A CA  1 
ATOM   1770 C C   . ALA A 1 267 ? -37.82302 8.63228   -55.60572 1.000 69.12000  ? 385 ALA A C   1 
ATOM   1771 O O   . ALA A 1 267 ? -38.08478 7.72668   -54.78930 1.000 55.59000  ? 385 ALA A O   1 
ATOM   1772 C CB  . ALA A 1 267 ? -35.98168 8.57909   -57.31841 1.000 73.49000  ? 385 ALA A CB  1 
ATOM   1773 N N   . HIS A 1 268 ? -37.86765 9.93910   -55.32696 1.000 61.96000  ? 386 HIS A N   1 
ATOM   1774 C CA  . HIS A 1 268 ? -38.24011 10.43015  -53.99874 1.000 57.65000  ? 386 HIS A CA  1 
ATOM   1775 C C   . HIS A 1 268 ? -39.72626 10.73345  -53.90284 1.000 54.90000  ? 386 HIS A C   1 
ATOM   1776 O O   . HIS A 1 268 ? -40.15379 11.65985  -53.21437 1.000 56.80000  ? 386 HIS A O   1 
ATOM   1777 C CB  . HIS A 1 268 ? -37.41071 11.65331  -53.64387 1.000 55.69000  ? 386 HIS A CB  1 
ATOM   1778 C CG  . HIS A 1 268 ? -35.94559 11.38397  -53.67376 1.000 58.68000  ? 386 HIS A CG  1 
ATOM   1779 N ND1 . HIS A 1 268 ? -35.12959 11.81493  -54.69835 1.000 61.15000  ? 386 HIS A ND1 1 
ATOM   1780 C CD2 . HIS A 1 268 ? -35.15843 10.66382  -52.84004 1.000 52.84000  ? 386 HIS A CD2 1 
ATOM   1781 C CE1 . HIS A 1 268 ? -33.89545 11.40134  -54.47637 1.000 61.09000  ? 386 HIS A CE1 1 
ATOM   1782 N NE2 . HIS A 1 268 ? -33.88435 10.70068  -53.35478 1.000 57.54000  ? 386 HIS A NE2 1 
ATOM   1783 N N   . ARG A 1 269 ? -40.51877 9.91150   -54.58347 1.000 56.22000  ? 387 ARG A N   1 
ATOM   1784 C CA  . ARG A 1 269 ? -41.95285 10.12294  -54.69961 1.000 52.02000  ? 387 ARG A CA  1 
ATOM   1785 C C   . ARG A 1 269 ? -42.63314 10.22584  -53.34267 1.000 48.55000  ? 387 ARG A C   1 
ATOM   1786 O O   . ARG A 1 269 ? -43.61949 10.95332  -53.18943 1.000 48.57000  ? 387 ARG A O   1 
ATOM   1787 C CB  . ARG A 1 269 ? -42.54719 8.96414   -55.48740 1.000 57.94000  ? 387 ARG A CB  1 
ATOM   1788 C CG  . ARG A 1 269 ? -43.88720 9.21189   -56.05850 1.000 44.40000  ? 387 ARG A CG  1 
ATOM   1789 C CD  . ARG A 1 269 ? -44.32052 8.00114   -56.82029 1.000 42.53000  ? 387 ARG A CD  1 
ATOM   1790 N NE  . ARG A 1 269 ? -45.75448 7.84845   -56.70365 1.000 47.70000  ? 387 ARG A NE  1 
ATOM   1791 C CZ  . ARG A 1 269 ? -46.44695 6.86747   -57.25635 1.000 45.01000  ? 387 ARG A CZ  1 
ATOM   1792 N NH1 . ARG A 1 269 ? -45.80941 5.94217   -57.97178 1.000 38.61000  ? 387 ARG A NH1 1 
ATOM   1793 N NH2 . ARG A 1 269 ? -47.77096 6.82179   -57.08662 1.000 41.77000  ? 387 ARG A NH2 1 
ATOM   1794 N N   . PHE A 1 270 ? -42.15000 9.47947   -52.34902 1.000 49.66000  ? 388 PHE A N   1 
ATOM   1795 C CA  . PHE A 1 270 ? -42.79524 9.48142   -51.04414 1.000 42.43000  ? 388 PHE A CA  1 
ATOM   1796 C C   . PHE A 1 270 ? -41.90268 10.01215  -49.92166 1.000 40.74000  ? 388 PHE A C   1 
ATOM   1797 O O   . PHE A 1 270 ? -42.22881 9.81132   -48.74884 1.000 45.47000  ? 388 PHE A O   1 
ATOM   1798 C CB  . PHE A 1 270 ? -43.30169 8.07901   -50.72006 1.000 42.76000  ? 388 PHE A CB  1 
ATOM   1799 C CG  . PHE A 1 270 ? -44.51137 7.68995   -51.51851 1.000 44.64000  ? 388 PHE A CG  1 
ATOM   1800 C CD1 . PHE A 1 270 ? -45.51673 8.60865   -51.75916 1.000 48.58000  ? 388 PHE A CD1 1 
ATOM   1801 C CD2 . PHE A 1 270 ? -44.61971 6.42323   -52.08227 1.000 43.52000  ? 388 PHE A CD2 1 
ATOM   1802 C CE1 . PHE A 1 270 ? -46.61343 8.25461   -52.52057 1.000 45.97000  ? 388 PHE A CE1 1 
ATOM   1803 C CE2 . PHE A 1 270 ? -45.71941 6.06919   -52.83469 1.000 34.80000  ? 388 PHE A CE2 1 
ATOM   1804 C CZ  . PHE A 1 270 ? -46.70777 6.97188   -53.05334 1.000 37.44000  ? 388 PHE A CZ  1 
ATOM   1805 N N   . LEU A 1 271 ? -40.81493 10.72582  -50.24404 1.000 38.66000  ? 389 LEU A N   1 
ATOM   1806 C CA  . LEU A 1 271 ? -39.95337 11.26958  -49.19356 1.000 45.96000  ? 389 LEU A CA  1 
ATOM   1807 C C   . LEU A 1 271 ? -40.72394 12.17868  -48.23217 1.000 40.86000  ? 389 LEU A C   1 
ATOM   1808 O O   . LEU A 1 271 ? -40.54813 12.09004  -47.01119 1.000 40.97000  ? 389 LEU A O   1 
ATOM   1809 C CB  . LEU A 1 271 ? -38.77759 12.02745  -49.80190 1.000 46.30000  ? 389 LEU A CB  1 
ATOM   1810 C CG  . LEU A 1 271 ? -37.73997 12.46429  -48.75745 1.000 42.46000  ? 389 LEU A CG  1 
ATOM   1811 C CD1 . LEU A 1 271 ? -37.11856 11.25618  -48.10805 1.000 33.40000  ? 389 LEU A CD1 1 
ATOM   1812 C CD2 . LEU A 1 271 ? -36.65821 13.28815  -49.40777 1.000 43.34000  ? 389 LEU A CD2 1 
ATOM   1813 N N   . PHE A 1 272 ? -41.58123 13.05461  -48.75282 1.000 38.90000  ? 390 PHE A N   1 
ATOM   1814 C CA  . PHE A 1 272 ? -42.35077 13.91074  -47.85746 1.000 40.56000  ? 390 PHE A CA  1 
ATOM   1815 C C   . PHE A 1 272 ? -43.16359 13.08780  -46.86409 1.000 41.87000  ? 390 PHE A C   1 
ATOM   1816 O O   . PHE A 1 272 ? -43.20996 13.40908  -45.67191 1.000 47.91000  ? 390 PHE A O   1 
ATOM   1817 C CB  . PHE A 1 272 ? -43.26503 14.84281  -48.64808 1.000 37.61000  ? 390 PHE A CB  1 
ATOM   1818 C CG  . PHE A 1 272 ? -44.19853 15.61789  -47.78779 1.000 46.17000  ? 390 PHE A CG  1 
ATOM   1819 C CD1 . PHE A 1 272 ? -43.74715 16.72767  -47.07606 1.000 49.36000  ? 390 PHE A CD1 1 
ATOM   1820 C CD2 . PHE A 1 272 ? -45.52639 15.23224  -47.65727 1.000 47.99000  ? 390 PHE A CD2 1 
ATOM   1821 C CE1 . PHE A 1 272 ? -44.60662 17.44482  -46.26280 1.000 43.31000  ? 390 PHE A CE1 1 
ATOM   1822 C CE2 . PHE A 1 272 ? -46.39385 15.94638  -46.85001 1.000 41.31000  ? 390 PHE A CE2 1 
ATOM   1823 C CZ  . PHE A 1 272 ? -45.93846 17.04617  -46.15028 1.000 43.99000  ? 390 PHE A CZ  1 
ATOM   1824 N N   . LEU A 1 273 ? -43.79504 12.00980  -47.32084 1.000 47.83000  ? 391 LEU A N   1 
ATOM   1825 C CA  . LEU A 1 273 ? -44.66788 11.26089  -46.42344 1.000 39.17000  ? 391 LEU A CA  1 
ATOM   1826 C C   . LEU A 1 273 ? -43.86270 10.44265  -45.42877 1.000 38.97000  ? 391 LEU A C   1 
ATOM   1827 O O   . LEU A 1 273 ? -44.26486 10.30979  -44.26392 1.000 44.12000  ? 391 LEU A O   1 
ATOM   1828 C CB  . LEU A 1 273 ? -45.63034 10.39094  -47.24113 1.000 42.00000  ? 391 LEU A CB  1 
ATOM   1829 C CG  . LEU A 1 273 ? -46.76758 11.19883  -47.90286 1.000 42.21000  ? 391 LEU A CG  1 
ATOM   1830 C CD1 . LEU A 1 273 ? -47.46103 10.42418  -49.00945 1.000 41.42000  ? 391 LEU A CD1 1 
ATOM   1831 C CD2 . LEU A 1 273 ? -47.79794 11.59978  -46.87182 1.000 39.13000  ? 391 LEU A CD2 1 
ATOM   1832 N N   . LYS A 1 274 ? -42.71339 9.92041   -45.86187 1.000 37.65000  ? 392 LYS A N   1 
ATOM   1833 C CA  . LYS A 1 274 ? -41.75331 9.32829   -44.92904 1.000 42.27000  ? 392 LYS A CA  1 
ATOM   1834 C C   . LYS A 1 274 ? -41.38193 10.29380  -43.81840 1.000 39.34000  ? 392 LYS A C   1 
ATOM   1835 O O   . LYS A 1 274 ? -41.41600 9.93609   -42.63862 1.000 43.50000  ? 392 LYS A O   1 
ATOM   1836 C CB  . LYS A 1 274 ? -40.49097 8.86527   -45.66208 1.000 43.56000  ? 392 LYS A CB  1 
ATOM   1837 C CG  . LYS A 1 274 ? -40.72427 7.64967   -46.52483 1.000 47.89000  ? 392 LYS A CG  1 
ATOM   1838 C CD  . LYS A 1 274 ? -39.46295 7.21764   -47.22885 1.000 61.42000  ? 392 LYS A CD  1 
ATOM   1839 C CE  . LYS A 1 274 ? -39.65425 6.00610   -48.15660 1.000 50.03000  ? 392 LYS A CE  1 
ATOM   1840 N NZ  . LYS A 1 274 ? -38.33801 5.69503   -48.75254 1.000 54.90000  ? 392 LYS A NZ  1 
ATOM   1841 N N   . ILE A 1 275 ? -41.02141 11.52217  -44.17761 1.000 37.92000  ? 393 ILE A N   1 
ATOM   1842 C CA  . ILE A 1 275 ? -40.68803 12.51672  -43.16797 1.000 43.81000  ? 393 ILE A CA  1 
ATOM   1843 C C   . ILE A 1 275 ? -41.86730 12.74465  -42.22405 1.000 39.51000  ? 393 ILE A C   1 
ATOM   1844 O O   . ILE A 1 275 ? -41.70552 12.72700  -40.99303 1.000 40.62000  ? 393 ILE A O   1 
ATOM   1845 C CB  . ILE A 1 275 ? -40.22247 13.81333  -43.85812 1.000 45.96000  ? 393 ILE A CB  1 
ATOM   1846 C CG1 . ILE A 1 275 ? -38.84725 13.58531  -44.49800 1.000 36.98000  ? 393 ILE A CG1 1 
ATOM   1847 C CG2 . ILE A 1 275 ? -40.23016 14.97775  -42.87544 1.000 35.78000  ? 393 ILE A CG2 1 
ATOM   1848 C CD1 . ILE A 1 275 ? -38.52047 14.54708  -45.56437 1.000 36.05000  ? 393 ILE A CD1 1 
ATOM   1849 N N   . MET A 1 276 ? -43.07229 12.93944  -42.77116 1.000 34.35000  ? 394 MET A N   1 
ATOM   1850 C CA  . MET A 1 276 ? -44.22553 13.11042  -41.88627 1.000 38.51000  ? 394 MET A CA  1 
ATOM   1851 C C   . MET A 1 276 ? -44.40416 11.89380  -40.97802 1.000 40.91000  ? 394 MET A C   1 
ATOM   1852 O O   . MET A 1 276 ? -44.69144 12.03398  -39.78599 1.000 43.35000  ? 394 MET A O   1 
ATOM   1853 C CB  . MET A 1 276 ? -45.49449 13.37034  -42.69735 1.000 33.57000  ? 394 MET A CB  1 
ATOM   1854 C CG  . MET A 1 276 ? -45.48489 14.62583  -43.52861 1.000 36.94000  ? 394 MET A CG  1 
ATOM   1855 S SD  . MET A 1 276 ? -45.03271 16.09246  -42.56867 1.000 42.41000  ? 394 MET A SD  1 
ATOM   1856 C CE  . MET A 1 276 ? -46.46601 16.33119  -41.47879 1.000 35.97000  ? 394 MET A CE  1 
ATOM   1857 N N   . ALA A 1 277 ? -44.22453 10.68919  -41.51169 1.000 39.68000  ? 395 ALA A N   1 
ATOM   1858 C CA  . ALA A 1 277 ? -44.33418 9.51865   -40.65940 1.000 37.92000  ? 395 ALA A CA  1 
ATOM   1859 C C   . ALA A 1 277 ? -43.35643 9.60639   -39.49817 1.000 38.68000  ? 395 ALA A C   1 
ATOM   1860 O O   . ALA A 1 277 ? -43.69749 9.26057   -38.35843 1.000 40.50000  ? 395 ALA A O   1 
ATOM   1861 C CB  . ALA A 1 277 ? -44.08447 8.24623   -41.47210 1.000 35.82000  ? 395 ALA A CB  1 
ATOM   1862 N N   . MET A 1 278 ? -42.12959 10.08308  -39.75966 1.000 44.49000  ? 396 MET A N   1 
ATOM   1863 C CA  . MET A 1 278 ? -41.14980 10.09988  -38.67747 1.000 46.02000  ? 396 MET A CA  1 
ATOM   1864 C C   . MET A 1 278 ? -41.37248 11.24721  -37.70284 1.000 41.98000  ? 396 MET A C   1 
ATOM   1865 O O   . MET A 1 278 ? -41.00665 11.13668  -36.52883 1.000 41.34000  ? 396 MET A O   1 
ATOM   1866 C CB  . MET A 1 278 ? -39.72671 10.13282  -39.21919 1.000 37.84000  ? 396 MET A CB  1 
ATOM   1867 C CG  . MET A 1 278 ? -39.41702 8.85338   -39.93688 1.000 39.50000  ? 396 MET A CG  1 
ATOM   1868 S SD  . MET A 1 278 ? -37.75188 8.77544   -40.51062 1.000 46.91000  ? 396 MET A SD  1 
ATOM   1869 C CE  . MET A 1 278 ? -36.88505 8.50492   -38.97462 1.000 42.57000  ? 396 MET A CE  1 
ATOM   1870 N N   . LEU A 1 279 ? -41.99787 12.32920  -38.15232 1.000 39.70000  ? 397 LEU A N   1 
ATOM   1871 C CA  . LEU A 1 279 ? -42.40050 13.36247  -37.21578 1.000 39.33000  ? 397 LEU A CA  1 
ATOM   1872 C C   . LEU A 1 279 ? -43.39244 12.80945  -36.20929 1.000 41.79000  ? 397 LEU A C   1 
ATOM   1873 O O   . LEU A 1 279 ? -43.24576 13.01280  -34.99815 1.000 45.56000  ? 397 LEU A O   1 
ATOM   1874 C CB  . LEU A 1 279 ? -42.98288 14.54267  -37.98020 1.000 39.67000  ? 397 LEU A CB  1 
ATOM   1875 C CG  . LEU A 1 279 ? -41.92016 15.45751  -38.62347 1.000 33.83000  ? 397 LEU A CG  1 
ATOM   1876 C CD1 . LEU A 1 279 ? -42.58760 16.68252  -39.14487 1.000 32.83000  ? 397 LEU A CD1 1 
ATOM   1877 C CD2 . LEU A 1 279 ? -40.83651 15.85442  -37.65803 1.000 26.96000  ? 397 LEU A CD2 1 
ATOM   1878 N N   . THR A 1 280 ? -44.38703 12.06129  -36.69392 1.000 47.80000  ? 398 THR A N   1 
ATOM   1879 C CA  . THR A 1 280 ? -45.38792 11.45034  -35.81846 1.000 42.22000  ? 398 THR A CA  1 
ATOM   1880 C C   . THR A 1 280 ? -44.76165 10.42906  -34.88094 1.000 40.83000  ? 398 THR A C   1 
ATOM   1881 O O   . THR A 1 280 ? -45.11283 10.35722  -33.70005 1.000 39.85000  ? 398 THR A O   1 
ATOM   1882 C CB  . THR A 1 280 ? -46.47047 10.77636  -36.66506 1.000 44.21000  ? 398 THR A CB  1 
ATOM   1883 O OG1 . THR A 1 280 ? -47.28478 11.76639  -37.31462 1.000 48.71000  ? 398 THR A OG1 1 
ATOM   1884 C CG2 . THR A 1 280 ? -47.34024 9.89147   -35.79774 1.000 43.35000  ? 398 THR A CG2 1 
ATOM   1885 N N   . GLU A 1 281 ? -43.85919 9.59677   -35.40227 1.000 43.55000  ? 399 GLU A N   1 
ATOM   1886 C CA  . GLU A 1 281 ? -43.15393 8.64558   -34.55369 1.000 44.83000  ? 399 GLU A CA  1 
ATOM   1887 C C   . GLU A 1 281 ? -42.28843 9.37436   -33.53311 1.000 47.52000  ? 399 GLU A C   1 
ATOM   1888 O O   . GLU A 1 281 ? -42.20847 8.96171   -32.36833 1.000 49.20000  ? 399 GLU A O   1 
ATOM   1889 C CB  . GLU A 1 281 ? -42.33734 7.69445   -35.43910 1.000 51.13000  ? 399 GLU A CB  1 
ATOM   1890 C CG  . GLU A 1 281 ? -41.31608 6.80050   -34.75444 1.000 55.17000  ? 399 GLU A CG  1 
ATOM   1891 C CD  . GLU A 1 281 ? -41.94872 5.65978   -34.00723 1.000 71.77000  ? 399 GLU A CD  1 
ATOM   1892 O OE1 . GLU A 1 281 ? -43.19965 5.53626   -34.05853 1.000 78.60000  ? 399 GLU A OE1 1 
ATOM   1893 O OE2 . GLU A 1 281 ? -41.19049 4.87775   -33.37755 1.000 70.22000  ? 399 GLU A OE2 1 
ATOM   1894 N N   . LEU A 1 282 ? -41.68185 10.49886  -33.94033 1.000 47.22000  ? 400 LEU A N   1 
ATOM   1895 C CA  . LEU A 1 282 ? -40.88838 11.32567  -33.02870 1.000 43.24000  ? 400 LEU A CA  1 
ATOM   1896 C C   . LEU A 1 282 ? -41.73687 11.99567  -31.95546 1.000 45.80000  ? 400 LEU A C   1 
ATOM   1897 O O   . LEU A 1 282 ? -41.25218 12.21623  -30.83824 1.000 47.57000  ? 400 LEU A O   1 
ATOM   1898 C CB  . LEU A 1 282 ? -40.11971 12.39747  -33.80393 1.000 47.07000  ? 400 LEU A CB  1 
ATOM   1899 C CG  . LEU A 1 282 ? -39.06619 13.14444  -32.97130 1.000 44.16000  ? 400 LEU A CG  1 
ATOM   1900 C CD1 . LEU A 1 282 ? -38.04285 12.15859  -32.46869 1.000 39.23000  ? 400 LEU A CD1 1 
ATOM   1901 C CD2 . LEU A 1 282 ? -38.37251 14.21422  -33.77454 1.000 35.57000  ? 400 LEU A CD2 1 
ATOM   1902 N N   . ARG A 1 283 ? -42.98597 12.34831  -32.26849 1.000 41.64000  ? 401 ARG A N   1 
ATOM   1903 C CA  . ARG A 1 283 ? -43.88339 12.87631  -31.23934 1.000 43.24000  ? 401 ARG A CA  1 
ATOM   1904 C C   . ARG A 1 283 ? -44.15614 11.83955  -30.15200 1.000 49.55000  ? 401 ARG A C   1 
ATOM   1905 O O   . ARG A 1 283 ? -44.22751 12.17382  -28.96082 1.000 51.66000  ? 401 ARG A O   1 
ATOM   1906 C CB  . ARG A 1 283 ? -45.18247 13.33913  -31.89531 1.000 44.27000  ? 401 ARG A CB  1 
ATOM   1907 C CG  . ARG A 1 283 ? -46.29482 13.73209  -30.96629 1.000 51.79000  ? 401 ARG A CG  1 
ATOM   1908 C CD  . ARG A 1 283 ? -47.23215 14.76107  -31.62185 1.000 57.19000  ? 401 ARG A CD  1 
ATOM   1909 N NE  . ARG A 1 283 ? -48.01364 15.44312  -30.59060 1.000 72.47000  ? 401 ARG A NE  1 
ATOM   1910 C CZ  . ARG A 1 283 ? -48.77208 16.52389  -30.77210 1.000 72.58000  ? 401 ARG A CZ  1 
ATOM   1911 N NH1 . ARG A 1 283 ? -48.85911 17.10856  -31.96678 1.000 65.13000  ? 401 ARG A NH1 1 
ATOM   1912 N NH2 . ARG A 1 283 ? -49.43549 17.03199  -29.73293 1.000 72.76000  ? 401 ARG A NH2 1 
ATOM   1913 N N   . SER A 1 284 ? -44.29251 10.56972  -30.54377 1.000 43.91000  ? 402 SER A N   1 
ATOM   1914 C CA  . SER A 1 284 ? -44.51422 9.50306   -29.57744 1.000 44.73000  ? 402 SER A CA  1 
ATOM   1915 C C   . SER A 1 284 ? -43.27327 9.25010   -28.72236 1.000 46.78000  ? 402 SER A C   1 
ATOM   1916 O O   . SER A 1 284 ? -43.38241 9.06034   -27.50749 1.000 48.66000  ? 402 SER A O   1 
ATOM   1917 C CB  . SER A 1 284 ? -44.94053 8.23431   -30.32327 1.000 51.76000  ? 402 SER A CB  1 
ATOM   1918 O OG  . SER A 1 284 ? -44.85317 7.07787   -29.50993 1.000 54.56000  ? 402 SER A OG  1 
ATOM   1919 N N   . ILE A 1 285 ? -42.08715 9.22798   -29.33615 1.000 45.62000  ? 403 ILE A N   1 
ATOM   1920 C CA  . ILE A 1 285 ? -40.86117 8.96207   -28.58108 1.000 46.76000  ? 403 ILE A CA  1 
ATOM   1921 C C   . ILE A 1 285 ? -40.59984 10.06959  -27.55438 1.000 50.23000  ? 403 ILE A C   1 
ATOM   1922 O O   . ILE A 1 285 ? -40.14394 9.80613   -26.43446 1.000 47.78000  ? 403 ILE A O   1 
ATOM   1923 C CB  . ILE A 1 285 ? -39.67792 8.79716   -29.55296 1.000 46.92000  ? 403 ILE A CB  1 
ATOM   1924 C CG1 . ILE A 1 285 ? -39.97425 7.69463   -30.56167 1.000 41.79000  ? 403 ILE A CG1 1 
ATOM   1925 C CG2 . ILE A 1 285 ? -38.39192 8.49628   -28.79890 1.000 42.87000  ? 403 ILE A CG2 1 
ATOM   1926 C CD1 . ILE A 1 285 ? -38.98202 7.64972   -31.68351 1.000 47.51000  ? 403 ILE A CD1 1 
ATOM   1927 N N   . ASN A 1 286 ? -40.86532 11.32469  -27.93270 1.000 47.66000  ? 404 ASN A N   1 
ATOM   1928 C CA  . ASN A 1 286 ? -40.81499 12.44316  -26.99803 1.000 38.27000  ? 404 ASN A CA  1 
ATOM   1929 C C   . ASN A 1 286 ? -41.58208 12.11608  -25.72136 1.000 45.40000  ? 404 ASN A C   1 
ATOM   1930 O O   . ASN A 1 286 ? -41.03131 12.16567  -24.61423 1.000 49.64000  ? 404 ASN A O   1 
ATOM   1931 C CB  . ASN A 1 286 ? -41.40240 13.67331  -27.69042 1.000 42.10000  ? 404 ASN A CB  1 
ATOM   1932 C CG  . ASN A 1 286 ? -41.21811 14.96494  -26.90862 1.000 44.21000  ? 404 ASN A CG  1 
ATOM   1933 O OD1 . ASN A 1 286 ? -40.69832 14.98251  -25.78852 1.000 47.16000  ? 404 ASN A OD1 1 
ATOM   1934 N ND2 . ASN A 1 286 ? -41.70848 16.06206  -27.49007 1.000 39.96000  ? 404 ASN A ND2 1 
ATOM   1935 N N   . ALA A 1 287 ? -42.85789 11.75260  -25.86181 1.000 49.68000  ? 405 ALA A N   1 
ATOM   1936 C CA  . ALA A 1 287 ? -43.67597 11.43456  -24.69315 1.000 49.22000  ? 405 ALA A CA  1 
ATOM   1937 C C   . ALA A 1 287 ? -43.05363 10.30934  -23.86770 1.000 47.92000  ? 405 ALA A C   1 
ATOM   1938 O O   . ALA A 1 287 ? -42.95191 10.42367  -22.63861 1.000 47.60000  ? 405 ALA A O   1 
ATOM   1939 C CB  . ALA A 1 287 ? -45.10774 11.08318  -25.12162 1.000 35.28000  ? 405 ALA A CB  1 
ATOM   1940 N N   . GLN A 1 288 ? -42.62403 9.21591   -24.51626 1.000 38.54000  ? 406 GLN A N   1 
ATOM   1941 C CA  . GLN A 1 288 ? -41.99170 8.13874   -23.75678 1.000 42.64000  ? 406 GLN A CA  1 
ATOM   1942 C C   . GLN A 1 288 ? -40.76406 8.64084   -23.00125 1.000 47.77000  ? 406 GLN A C   1 
ATOM   1943 O O   . GLN A 1 288 ? -40.59616 8.36021   -21.80339 1.000 46.61000  ? 406 GLN A O   1 
ATOM   1944 C CB  . GLN A 1 288 ? -41.61202 6.96444   -24.66240 1.000 53.48000  ? 406 GLN A CB  1 
ATOM   1945 C CG  . GLN A 1 288 ? -41.54856 5.61404   -23.92418 1.000 54.10000  ? 406 GLN A CG  1 
ATOM   1946 N N   . HIS A 1 289 ? -39.89627 9.39662   -23.67865 1.000 43.67000  ? 407 HIS A N   1 
ATOM   1947 C CA  . HIS A 1 289 ? -38.67358 9.82676   -23.01117 1.000 48.15000  ? 407 HIS A CA  1 
ATOM   1948 C C   . HIS A 1 289 ? -38.95224 10.87902  -21.94960 1.000 42.75000  ? 407 HIS A C   1 
ATOM   1949 O O   . HIS A 1 289 ? -38.24744 10.92173  -20.93945 1.000 46.97000  ? 407 HIS A O   1 
ATOM   1950 C CB  . HIS A 1 289 ? -37.64161 10.32481  -24.02469 1.000 44.14000  ? 407 HIS A CB  1 
ATOM   1951 C CG  . HIS A 1 289 ? -36.90000 9.22054   -24.72320 1.000 51.30000  ? 407 HIS A CG  1 
ATOM   1952 N ND1 . HIS A 1 289 ? -35.57092 8.93898   -24.47712 1.000 55.43000  ? 407 HIS A ND1 1 
ATOM   1953 C CD2 . HIS A 1 289 ? -37.30743 8.31791   -25.64981 1.000 54.38000  ? 407 HIS A CD2 1 
ATOM   1954 C CE1 . HIS A 1 289 ? -35.19033 7.91759   -25.22765 1.000 54.48000  ? 407 HIS A CE1 1 
ATOM   1955 N NE2 . HIS A 1 289 ? -36.22502 7.52256   -25.94907 1.000 55.15000  ? 407 HIS A NE2 1 
ATOM   1956 N N   . THR A 1 290 ? -39.97557 11.71968  -22.13430 1.000 42.34000  ? 408 THR A N   1 
ATOM   1957 C CA  . THR A 1 290 ? -40.33018 12.65289  -21.06482 1.000 43.56000  ? 408 THR A CA  1 
ATOM   1958 C C   . THR A 1 290 ? -40.75508 11.89597  -19.80734 1.000 47.77000  ? 408 THR A C   1 
ATOM   1959 O O   . THR A 1 290 ? -40.37845 12.26648  -18.69205 1.000 50.44000  ? 408 THR A O   1 
ATOM   1960 C CB  . THR A 1 290 ? -41.43152 13.62468  -21.53345 1.000 46.44000  ? 408 THR A CB  1 
ATOM   1961 O OG1 . THR A 1 290 ? -40.95167 14.43953  -22.61788 1.000 52.96000  ? 408 THR A OG1 1 
ATOM   1962 C CG2 . THR A 1 290 ? -41.86212 14.54185  -20.42799 1.000 38.25000  ? 408 THR A CG2 1 
ATOM   1963 N N   . GLN A 1 291 ? -41.50657 10.80573  -19.97212 1.000 49.66000  ? 409 GLN A N   1 
ATOM   1964 C CA  . GLN A 1 291 ? -41.92043 10.01288  -18.82366 1.000 46.69000  ? 409 GLN A CA  1 
ATOM   1965 C C   . GLN A 1 291 ? -40.72525 9.32602   -18.17584 1.000 48.31000  ? 409 GLN A C   1 
ATOM   1966 O O   . GLN A 1 291 ? -40.68041 9.16332   -16.94493 1.000 47.71000  ? 409 GLN A O   1 
ATOM   1967 C CB  . GLN A 1 291 ? -42.97991 8.99967   -19.25345 1.000 46.54000  ? 409 GLN A CB  1 
ATOM   1968 C CG  . GLN A 1 291 ? -44.31313 9.64928   -19.58832 1.000 46.77000  ? 409 GLN A CG  1 
ATOM   1969 C CD  . GLN A 1 291 ? -45.21159 8.77339   -20.45000 1.000 63.95000  ? 409 GLN A CD  1 
ATOM   1970 O OE1 . GLN A 1 291 ? -44.93903 7.58164   -20.67665 1.000 64.46000  ? 409 GLN A OE1 1 
ATOM   1971 N NE2 . GLN A 1 291 ? -46.28176 9.37322   -20.96684 1.000 70.82000  ? 409 GLN A NE2 1 
ATOM   1972 N N   . ARG A 1 292 ? -39.74792 8.91293   -18.98591 1.000 44.72000  ? 410 ARG A N   1 
ATOM   1973 C CA  . ARG A 1 292 ? -38.50479 8.38514   -18.43099 1.000 49.37000  ? 410 ARG A CA  1 
ATOM   1974 C C   . ARG A 1 292 ? -37.82741 9.41591   -17.53425 1.000 47.59000  ? 410 ARG A C   1 
ATOM   1975 O O   . ARG A 1 292 ? -37.41348 9.10143   -16.40736 1.000 45.55000  ? 410 ARG A O   1 
ATOM   1976 C CB  . ARG A 1 292 ? -37.57040 7.96922   -19.56406 1.000 50.78000  ? 410 ARG A CB  1 
ATOM   1977 C CG  . ARG A 1 292 ? -37.84170 6.59943   -20.12591 1.000 50.22000  ? 410 ARG A CG  1 
ATOM   1978 C CD  . ARG A 1 292 ? -36.93238 6.36251   -21.29088 1.000 51.68000  ? 410 ARG A CD  1 
ATOM   1979 N NE  . ARG A 1 292 ? -37.61186 5.63683   -22.34544 1.000 59.02000  ? 410 ARG A NE  1 
ATOM   1980 C CZ  . ARG A 1 292 ? -37.03932 4.70152   -23.08088 1.000 54.78000  ? 410 ARG A CZ  1 
ATOM   1981 N NH1 . ARG A 1 292 ? -35.76323 4.41197   -22.89281 1.000 52.14000  ? 410 ARG A NH1 1 
ATOM   1982 N NH2 . ARG A 1 292 ? -37.73488 4.09577   -24.03236 1.000 59.64000  ? 410 ARG A NH2 1 
ATOM   1983 N N   . LEU A 1 293 ? -37.69786 10.65526  -18.02950 1.000 42.13000  ? 411 LEU A N   1 
ATOM   1984 C CA  . LEU A 1 293 ? -37.08347 11.72207  -17.24876 1.000 39.52000  ? 411 LEU A CA  1 
ATOM   1985 C C   . LEU A 1 293 ? -37.77279 11.87598  -15.90280 1.000 47.04000  ? 411 LEU A C   1 
ATOM   1986 O O   . LEU A 1 293 ? -37.11003 11.98966  -14.86761 1.000 52.52000  ? 411 LEU A O   1 
ATOM   1987 C CB  . LEU A 1 293 ? -37.13091 13.04251  -18.02500 1.000 46.32000  ? 411 LEU A CB  1 
ATOM   1988 C CG  . LEU A 1 293 ? -36.57559 14.29334  -17.32116 1.000 41.92000  ? 411 LEU A CG  1 
ATOM   1989 C CD1 . LEU A 1 293 ? -35.06160 14.21086  -17.08293 1.000 52.06000  ? 411 LEU A CD1 1 
ATOM   1990 C CD2 . LEU A 1 293 ? -36.95801 15.56360  -18.04448 1.000 42.36000  ? 411 LEU A CD2 1 
ATOM   1991 N N   . LEU A 1 294 ? -39.11079 11.86139  -15.89406 1.000 42.36000  ? 412 LEU A N   1 
ATOM   1992 C CA  . LEU A 1 294 ? -39.83111 12.06534  -14.64307 1.000 43.05000  ? 412 LEU A CA  1 
ATOM   1993 C C   . LEU A 1 294 ? -39.60479 10.92286  -13.66270 1.000 46.30000  ? 412 LEU A C   1 
ATOM   1994 O O   . LEU A 1 294 ? -39.45212 11.16222  -12.45853 1.000 50.29000  ? 412 LEU A O   1 
ATOM   1995 C CB  . LEU A 1 294 ? -41.32114 12.26084  -14.90223 1.000 44.42000  ? 412 LEU A CB  1 
ATOM   1996 C CG  . LEU A 1 294 ? -41.68154 13.49916  -15.72557 1.000 54.35000  ? 412 LEU A CG  1 
ATOM   1997 C CD1 . LEU A 1 294 ? -43.10277 13.90935  -15.40859 1.000 47.78000  ? 412 LEU A CD1 1 
ATOM   1998 C CD2 . LEU A 1 294 ? -40.69309 14.68449  -15.54769 1.000 47.06000  ? 412 LEU A CD2 1 
ATOM   1999 N N   . ARG A 1 295 ? -39.57515 9.67816   -14.14942 1.000 47.98000  ? 413 ARG A N   1 
ATOM   2000 C CA  . ARG A 1 295 ? -39.34482 8.55173   -13.25304 1.000 37.03000  ? 413 ARG A CA  1 
ATOM   2001 C C   . ARG A 1 295 ? -37.95496 8.61799   -12.64975 1.000 47.83000  ? 413 ARG A C   1 
ATOM   2002 O O   . ARG A 1 295 ? -37.78510 8.41435   -11.44083 1.000 56.91000  ? 413 ARG A O   1 
ATOM   2003 C CB  . ARG A 1 295 ? -39.54011 7.23708   -13.99485 1.000 49.38000  ? 413 ARG A CB  1 
ATOM   2004 C CG  . ARG A 1 295 ? -40.92991 7.02080   -14.54823 1.000 46.76000  ? 413 ARG A CG  1 
ATOM   2005 C CD  . ARG A 1 295 ? -41.14521 5.57293   -14.93712 1.000 41.78000  ? 413 ARG A CD  1 
ATOM   2006 N NE  . ARG A 1 295 ? -40.69283 5.29193   -16.29621 1.000 54.38000  ? 413 ARG A NE  1 
ATOM   2007 C CZ  . ARG A 1 295 ? -41.44568 5.39524   -17.39029 1.000 52.55000  ? 413 ARG A CZ  1 
ATOM   2008 N NH1 . ARG A 1 295 ? -42.70986 5.78364   -17.30229 1.000 48.99000  ? 413 ARG A NH1 1 
ATOM   2009 N NH2 . ARG A 1 295 ? -40.92533 5.09917   -18.57836 1.000 51.06000  ? 413 ARG A NH2 1 
ATOM   2010 N N   . ILE A 1 296 ? -36.94794 8.91592   -13.47739 1.000 50.99000  ? 414 ILE A N   1 
ATOM   2011 C CA  . ILE A 1 296 ? -35.58111 9.07922   -12.97504 1.000 55.23000  ? 414 ILE A CA  1 
ATOM   2012 C C   . ILE A 1 296 ? -35.51779 10.22166  -11.97435 1.000 50.05000  ? 414 ILE A C   1 
ATOM   2013 O O   . ILE A 1 296 ? -34.91094 10.10530  -10.90331 1.000 53.69000  ? 414 ILE A O   1 
ATOM   2014 C CB  . ILE A 1 296 ? -34.60600 9.32633   -14.13971 1.000 51.94000  ? 414 ILE A CB  1 
ATOM   2015 C CG1 . ILE A 1 296 ? -34.62931 8.15890   -15.11840 1.000 48.49000  ? 414 ILE A CG1 1 
ATOM   2016 C CG2 . ILE A 1 296 ? -33.18722 9.60865   -13.61728 1.000 42.30000  ? 414 ILE A CG2 1 
ATOM   2017 C CD1 . ILE A 1 296 ? -34.08522 8.52592   -16.45409 1.000 44.68000  ? 414 ILE A CD1 1 
ATOM   2018 N N   . GLN A 1 297 ? -36.13122 11.35260  -12.32880 1.000 49.03000  ? 415 GLN A N   1 
ATOM   2019 C CA  . GLN A 1 297 ? -36.10590 12.54212  -11.48410 1.000 56.44000  ? 415 GLN A CA  1 
ATOM   2020 C C   . GLN A 1 297 ? -36.77003 12.27803  -10.13638 1.000 63.29000  ? 415 GLN A C   1 
ATOM   2021 O O   . GLN A 1 297 ? -36.31145 12.79263  -9.10499  1.000 56.46000  ? 415 GLN A O   1 
ATOM   2022 C CB  . GLN A 1 297 ? -36.77927 13.70026  -12.23854 1.000 49.49000  ? 415 GLN A CB  1 
ATOM   2023 C CG  . GLN A 1 297 ? -36.98697 14.97871  -11.45683 1.000 54.24000  ? 415 GLN A CG  1 
ATOM   2024 C CD  . GLN A 1 297 ? -35.76138 15.87120  -11.37608 1.000 52.58000  ? 415 GLN A CD  1 
ATOM   2025 O OE1 . GLN A 1 297 ? -34.69014 15.54597  -11.88707 1.000 49.78000  ? 415 GLN A OE1 1 
ATOM   2026 N NE2 . GLN A 1 297 ? -35.91500 17.00274  -10.70344 1.000 56.16000  ? 415 GLN A NE2 1 
ATOM   2027 N N   . ASP A 1 298 ? -37.82567 11.44957  -10.12906 1.000 60.26000  ? 416 ASP A N   1 
ATOM   2028 C CA  . ASP A 1 298 ? -38.53875 11.11753  -8.89839  1.000 54.91000  ? 416 ASP A CA  1 
ATOM   2029 C C   . ASP A 1 298 ? -37.61269 10.53331  -7.83956  1.000 57.65000  ? 416 ASP A C   1 
ATOM   2030 O O   . ASP A 1 298 ? -37.71906 10.87257  -6.65738  1.000 62.00000  ? 416 ASP A O   1 
ATOM   2031 C CB  . ASP A 1 298 ? -39.66227 10.13823  -9.22017  1.000 57.79000  ? 416 ASP A CB  1 
ATOM   2032 C CG  . ASP A 1 298 ? -40.72745 10.10014  -8.15739  1.000 64.10000  ? 416 ASP A CG  1 
ATOM   2033 O OD1 . ASP A 1 298 ? -40.92402 11.12664  -7.46482  1.000 67.57000  ? 416 ASP A OD1 1 
ATOM   2034 O OD2 . ASP A 1 298 ? -41.39300 9.04578   -8.04713  1.000 63.08000  ? 416 ASP A OD2 1 
ATOM   2035 N N   . ILE A 1 299 ? -36.70723 9.64995   -8.23891  1.000 58.42000  ? 417 ILE A N   1 
ATOM   2036 C CA  . ILE A 1 299 ? -35.87610 8.93575   -7.28317  1.000 60.35000  ? 417 ILE A CA  1 
ATOM   2037 C C   . ILE A 1 299 ? -34.43932 9.43236   -7.25762  1.000 59.59000  ? 417 ILE A C   1 
ATOM   2038 O O   . ILE A 1 299 ? -33.71236 9.11512   -6.30367  1.000 60.33000  ? 417 ILE A O   1 
ATOM   2039 C CB  . ILE A 1 299 ? -35.91038 7.42089   -7.55707  1.000 62.94000  ? 417 ILE A CB  1 
ATOM   2040 C CG1 . ILE A 1 299 ? -35.24900 7.11597   -8.89513  1.000 62.69000  ? 417 ILE A CG1 1 
ATOM   2041 C CG2 . ILE A 1 299 ? -37.35017 6.93527   -7.56162  1.000 65.26000  ? 417 ILE A CG2 1 
ATOM   2042 C CD1 . ILE A 1 299 ? -34.96332 5.65622   -9.10493  1.000 61.01000  ? 417 ILE A CD1 1 
ATOM   2043 N N   . HIS A 1 300 ? -34.00446 10.18714  -8.26209  1.000 55.63000  ? 418 HIS A N   1 
ATOM   2044 C CA  . HIS A 1 300 ? -32.64569 10.72576  -8.29753  1.000 55.88000  ? 418 HIS A CA  1 
ATOM   2045 C C   . HIS A 1 300 ? -32.66314 12.05319  -9.03475  1.000 58.31000  ? 418 HIS A C   1 
ATOM   2046 O O   . HIS A 1 300 ? -32.34495 12.13403  -10.22764 1.000 53.14000  ? 418 HIS A O   1 
ATOM   2047 C CB  . HIS A 1 300 ? -31.66915 9.75357   -8.95192  1.000 55.69000  ? 418 HIS A CB  1 
ATOM   2048 C CG  . HIS A 1 300 ? -30.26736 10.26821  -8.98736  1.000 59.48000  ? 418 HIS A CG  1 
ATOM   2049 N ND1 . HIS A 1 300 ? -29.36645 10.04201  -7.96932  1.000 61.37000  ? 418 HIS A ND1 1 
ATOM   2050 C CD2 . HIS A 1 300 ? -29.61152 11.00604  -9.91480  1.000 55.41000  ? 418 HIS A CD2 1 
ATOM   2051 C CE1 . HIS A 1 300 ? -28.21565 10.61868  -8.26777  1.000 62.16000  ? 418 HIS A CE1 1 
ATOM   2052 N NE2 . HIS A 1 300 ? -28.33769 11.20932  -9.44345  1.000 62.20000  ? 418 HIS A NE2 1 
ATOM   2053 N N   . PRO A 1 301 ? -33.00574 13.13362  -8.33118  1.000 59.61000  ? 419 PRO A N   1 
ATOM   2054 C CA  . PRO A 1 301 ? -33.20218 14.42693  -9.00246  1.000 49.17000  ? 419 PRO A CA  1 
ATOM   2055 C C   . PRO A 1 301 ? -31.89331 14.96184  -9.56490  1.000 48.45000  ? 419 PRO A C   1 
ATOM   2056 O O   . PRO A 1 301 ? -30.85543 14.94490  -8.89972  1.000 52.41000  ? 419 PRO A O   1 
ATOM   2057 C CB  . PRO A 1 301 ? -33.74378 15.32004  -7.88403  1.000 53.46000  ? 419 PRO A CB  1 
ATOM   2058 C CG  . PRO A 1 301 ? -33.16376 14.73056  -6.63627  1.000 55.42000  ? 419 PRO A CG  1 
ATOM   2059 C CD  . PRO A 1 301 ? -33.09206 13.24272  -6.86513  1.000 51.69000  ? 419 PRO A CD  1 
ATOM   2060 N N   . PHE A 1 302 ? -31.95030 15.44454  -10.80363 1.000 51.43000  ? 420 PHE A N   1 
ATOM   2061 C CA  . PHE A 1 302 ? -30.73934 15.83449  -11.51317 1.000 47.00000  ? 420 PHE A CA  1 
ATOM   2062 C C   . PHE A 1 302 ? -31.02259 16.87700  -12.59661 1.000 48.61000  ? 420 PHE A C   1 
ATOM   2063 O O   . PHE A 1 302 ? -30.08877 17.50171  -13.10607 1.000 57.88000  ? 420 PHE A O   1 
ATOM   2064 C CB  . PHE A 1 302 ? -30.06168 14.59614  -12.11478 1.000 41.12000  ? 420 PHE A CB  1 
ATOM   2065 C CG  . PHE A 1 302 ? -30.67924 14.12662  -13.39517 1.000 39.82000  ? 420 PHE A CG  1 
ATOM   2066 C CD1 . PHE A 1 302 ? -31.85792 13.39809  -13.38481 1.000 45.10000  ? 420 PHE A CD1 1 
ATOM   2067 C CD2 . PHE A 1 302 ? -30.08614 14.41559  -14.61189 1.000 44.53000  ? 420 PHE A CD2 1 
ATOM   2068 C CE1 . PHE A 1 302 ? -32.44652 12.96753  -14.56817 1.000 46.91000  ? 420 PHE A CE1 1 
ATOM   2069 C CE2 . PHE A 1 302 ? -30.65574 13.99004  -15.80024 1.000 47.26000  ? 420 PHE A CE2 1 
ATOM   2070 C CZ  . PHE A 1 302 ? -31.84442 13.25651  -15.77589 1.000 49.96000  ? 420 PHE A CZ  1 
ATOM   2071 N N   . ALA A 1 303 ? -32.29363 17.10164  -12.93172 1.000 49.10000  ? 421 ALA A N   1 
ATOM   2072 C CA  . ALA A 1 303 ? -32.64482 18.00113  -14.02925 1.000 45.60000  ? 421 ALA A CA  1 
ATOM   2073 C C   . ALA A 1 303 ? -32.28051 19.44910  -13.70834 1.000 46.92000  ? 421 ALA A C   1 
ATOM   2074 O O   . ALA A 1 303 ? -32.39892 19.89438  -12.56610 1.000 55.65000  ? 421 ALA A O   1 
ATOM   2075 C CB  . ALA A 1 303 ? -34.13872 17.89965  -14.33259 1.000 47.54000  ? 421 ALA A CB  1 
ATOM   2076 N N   . THR A 1 304 ? -31.84065 20.18789  -14.72882 1.000 45.96000  ? 422 THR A N   1 
ATOM   2077 C CA  . THR A 1 304 ? -31.54230 21.60394  -14.57593 1.000 41.19000  ? 422 THR A CA  1 
ATOM   2078 C C   . THR A 1 304 ? -32.83468 22.41528  -14.42770 1.000 50.53000  ? 422 THR A C   1 
ATOM   2079 O O   . THR A 1 304 ? -33.92641 21.94800  -14.76917 1.000 49.28000  ? 422 THR A O   1 
ATOM   2080 C CB  . THR A 1 304 ? -30.74030 22.12399  -15.77648 1.000 42.20000  ? 422 THR A CB  1 
ATOM   2081 O OG1 . THR A 1 304 ? -31.51903 22.01335  -16.97169 1.000 41.45000  ? 422 THR A OG1 1 
ATOM   2082 C CG2 . THR A 1 304 ? -29.41295 21.37867  -15.94067 1.000 42.63000  ? 422 THR A CG2 1 
ATOM   2083 N N   . PRO A 1 305 ? -32.73731 23.64202  -13.91296 1.000 52.08000  ? 423 PRO A N   1 
ATOM   2084 C CA  . PRO A 1 305 ? -33.95669 24.45341  -13.78771 1.000 44.08000  ? 423 PRO A CA  1 
ATOM   2085 C C   . PRO A 1 305 ? -34.66754 24.67088  -15.11371 1.000 53.16000  ? 423 PRO A C   1 
ATOM   2086 O O   . PRO A 1 305 ? -35.90851 24.61336  -15.15897 1.000 53.73000  ? 423 PRO A O   1 
ATOM   2087 C CB  . PRO A 1 305 ? -33.43538 25.76429  -13.18484 1.000 55.99000  ? 423 PRO A CB  1 
ATOM   2088 C CG  . PRO A 1 305 ? -32.15234 25.38344  -12.47883 1.000 49.55000  ? 423 PRO A CG  1 
ATOM   2089 C CD  . PRO A 1 305 ? -31.55571 24.29919  -13.30935 1.000 50.05000  ? 423 PRO A CD  1 
ATOM   2090 N N   . LEU A 1 306 ? -33.91544 24.90385  -16.20243 1.000 48.56000  ? 424 LEU A N   1 
ATOM   2091 C CA  . LEU A 1 306 ? -34.55126 25.03234  -17.51148 1.000 41.41000  ? 424 LEU A CA  1 
ATOM   2092 C C   . LEU A 1 306 ? -35.25462 23.74427  -17.90836 1.000 44.00000  ? 424 LEU A C   1 
ATOM   2093 O O   . LEU A 1 306 ? -36.33953 23.78414  -18.50354 1.000 45.88000  ? 424 LEU A O   1 
ATOM   2094 C CB  . LEU A 1 306 ? -33.53823 25.42741  -18.58106 1.000 39.25000  ? 424 LEU A CB  1 
ATOM   2095 C CG  . LEU A 1 306 ? -34.23110 25.68890  -19.92403 1.000 38.27000  ? 424 LEU A CG  1 
ATOM   2096 C CD1 . LEU A 1 306 ? -35.25262 26.81838  -19.80456 1.000 46.77000  ? 424 LEU A CD1 1 
ATOM   2097 C CD2 . LEU A 1 306 ? -33.24902 25.96598  -21.02369 1.000 27.83000  ? 424 LEU A CD2 1 
ATOM   2098 N N   . MET A 1 307 ? -34.65617 22.58834  -17.58793 1.000 48.03000  ? 425 MET A N   1 
ATOM   2099 C CA  . MET A 1 307 ? -35.33357 21.32321  -17.87280 1.000 50.34000  ? 425 MET A CA  1 
ATOM   2100 C C   . MET A 1 307 ? -36.56265 21.14916  -17.00013 1.000 48.90000  ? 425 MET A C   1 
ATOM   2101 O O   . MET A 1 307 ? -37.58934 20.64098  -17.46562 1.000 50.80000  ? 425 MET A O   1 
ATOM   2102 C CB  . MET A 1 307 ? -34.40407 20.12051  -17.69133 1.000 45.28000  ? 425 MET A CB  1 
ATOM   2103 C CG  . MET A 1 307 ? -33.27484 20.02160  -18.69918 1.000 42.86000  ? 425 MET A CG  1 
ATOM   2104 S SD  . MET A 1 307 ? -31.96844 18.88285  -18.15261 1.000 43.65000  ? 425 MET A SD  1 
ATOM   2105 C CE  . MET A 1 307 ? -32.84174 17.29851  -18.22270 1.000 36.78000  ? 425 MET A CE  1 
ATOM   2106 N N   . GLN A 1 308 ? -36.47606 21.54845  -15.72988 1.000 46.49000  ? 426 GLN A N   1 
ATOM   2107 C CA  . GLN A 1 308 ? -37.64518 21.44543  -14.86915 1.000 49.85000  ? 426 GLN A CA  1 
ATOM   2108 C C   . GLN A 1 308 ? -38.83238 22.17328  -15.49495 1.000 48.62000  ? 426 GLN A C   1 
ATOM   2109 O O   . GLN A 1 308 ? -39.94814 21.64482  -15.53846 1.000 46.70000  ? 426 GLN A O   1 
ATOM   2110 C CB  . GLN A 1 308 ? -37.30567 21.97776  -13.47478 1.000 45.08000  ? 426 GLN A CB  1 
ATOM   2111 C CG  . GLN A 1 308 ? -36.46140 21.01364  -12.63819 1.000 49.48000  ? 426 GLN A CG  1 
ATOM   2112 C CD  . GLN A 1 308 ? -35.91791 21.63012  -11.34073 1.000 56.51000  ? 426 GLN A CD  1 
ATOM   2113 O OE1 . GLN A 1 308 ? -36.19947 22.78280  -11.01510 1.000 63.29000  ? 426 GLN A OE1 1 
ATOM   2114 N NE2 . GLN A 1 308 ? -35.15670 20.84401  -10.58505 1.000 60.30000  ? 426 GLN A NE2 1 
ATOM   2115 N N   . GLU A 1 309 ? -38.59079 23.34772  -16.06421 1.000 48.07000  ? 427 GLU A N   1 
ATOM   2116 C CA  . GLU A 1 309 ? -39.68001 24.10260  -16.66897 1.000 48.26000  ? 427 GLU A CA  1 
ATOM   2117 C C   . GLU A 1 309 ? -40.17748 23.43913  -17.94645 1.000 48.19000  ? 427 GLU A C   1 
ATOM   2118 O O   . GLU A 1 309 ? -41.38940 23.34673  -18.16973 1.000 44.99000  ? 427 GLU A O   1 
ATOM   2119 C CB  . GLU A 1 309 ? -39.21758 25.52697  -16.95205 1.000 47.98000  ? 427 GLU A CB  1 
ATOM   2120 C CG  . GLU A 1 309 ? -39.09118 26.37030  -15.72153 1.000 47.39000  ? 427 GLU A CG  1 
ATOM   2121 C CD  . GLU A 1 309 ? -38.91375 27.82457  -16.05464 1.000 51.05000  ? 427 GLU A CD  1 
ATOM   2122 O OE1 . GLU A 1 309 ? -39.00167 28.15224  -17.25546 1.000 49.53000  ? 427 GLU A OE1 1 
ATOM   2123 O OE2 . GLU A 1 309 ? -38.68928 28.62613  -15.12413 1.000 52.51000  ? 427 GLU A OE2 1 
ATOM   2124 N N   . LEU A 1 310 ? -39.25612 22.96803  -18.79256 1.000 51.43000  ? 428 LEU A N   1 
ATOM   2125 C CA  . LEU A 1 310 ? -39.63264 22.43363  -20.09794 1.000 46.81000  ? 428 LEU A CA  1 
ATOM   2126 C C   . LEU A 1 310 ? -40.47911 21.17520  -19.98584 1.000 50.30000  ? 428 LEU A C   1 
ATOM   2127 O O   . LEU A 1 310 ? -41.35986 20.94930  -20.82613 1.000 57.36000  ? 428 LEU A O   1 
ATOM   2128 C CB  . LEU A 1 310 ? -38.38136 22.14367  -20.92488 1.000 48.58000  ? 428 LEU A CB  1 
ATOM   2129 C CG  . LEU A 1 310 ? -37.76478 23.38432  -21.58304 1.000 53.25000  ? 428 LEU A CG  1 
ATOM   2130 C CD1 . LEU A 1 310 ? -36.41053 23.04425  -22.15199 1.000 47.98000  ? 428 LEU A CD1 1 
ATOM   2131 C CD2 . LEU A 1 310 ? -38.67384 23.96456  -22.66287 1.000 44.03000  ? 428 LEU A CD2 1 
ATOM   2132 N N   . PHE A 1 311 ? -40.23593 20.34171  -18.97328 1.000 48.94000  ? 429 PHE A N   1 
ATOM   2133 C CA  . PHE A 1 311 ? -40.85637 19.02339  -18.90117 1.000 55.48000  ? 429 PHE A CA  1 
ATOM   2134 C C   . PHE A 1 311 ? -41.82452 18.86228  -17.72744 1.000 59.16000  ? 429 PHE A C   1 
ATOM   2135 O O   . PHE A 1 311 ? -42.17808 17.73092  -17.37817 1.000 58.52000  ? 429 PHE A O   1 
ATOM   2136 C CB  . PHE A 1 311 ? -39.77490 17.94384  -18.85360 1.000 52.23000  ? 429 PHE A CB  1 
ATOM   2137 C CG  . PHE A 1 311 ? -38.88268 17.94993  -20.05344 1.000 56.09000  ? 429 PHE A CG  1 
ATOM   2138 C CD1 . PHE A 1 311 ? -39.33624 17.45445  -21.27381 1.000 58.70000  ? 429 PHE A CD1 1 
ATOM   2139 C CD2 . PHE A 1 311 ? -37.59793 18.47245  -19.97989 1.000 57.61000  ? 429 PHE A CD2 1 
ATOM   2140 C CE1 . PHE A 1 311 ? -38.51704 17.47648  -22.41865 1.000 52.50000  ? 429 PHE A CE1 1 
ATOM   2141 C CE2 . PHE A 1 311 ? -36.77173 18.49748  -21.10973 1.000 56.00000  ? 429 PHE A CE2 1 
ATOM   2142 C CZ  . PHE A 1 311 ? -37.23728 17.99599  -22.33211 1.000 54.64000  ? 429 PHE A CZ  1 
ATOM   2143 N N   . GLY A 1 312 ? -42.27311 19.95673  -17.12388 1.000 56.89000  ? 430 GLY A N   1 
ATOM   2144 C CA  . GLY A 1 312 ? -43.26125 19.84267  -16.06613 1.000 56.59000  ? 430 GLY A CA  1 
ATOM   2145 C C   . GLY A 1 312 ? -42.76723 19.23813  -14.76740 1.000 61.15000  ? 430 GLY A C   1 
ATOM   2146 O O   . GLY A 1 312 ? -43.49701 18.46943  -14.12898 1.000 73.20000  ? 430 GLY A O   1 
ATOM   2147 N N   . ILE A 1 313 ? -41.55345 19.56242  -14.35798 1.000 65.17000  ? 431 ILE A N   1 
ATOM   2148 C CA  . ILE A 1 313 ? -41.04552 19.17987  -13.04411 1.000 70.90000  ? 431 ILE A CA  1 
ATOM   2149 C C   . ILE A 1 313 ? -41.25821 20.34722  -12.09147 1.000 75.06000  ? 431 ILE A C   1 
ATOM   2150 O O   . ILE A 1 313 ? -40.95965 21.50554  -12.42673 1.000 62.62000  ? 431 ILE A O   1 
ATOM   2151 C CB  . ILE A 1 313 ? -39.55733 18.77656  -13.10607 1.000 63.00000  ? 431 ILE A CB  1 
ATOM   2152 C CG1 . ILE A 1 313 ? -39.34965 17.64123  -14.09570 1.000 55.15000  ? 431 ILE A CG1 1 
ATOM   2153 C CG2 . ILE A 1 313 ? -39.04639 18.33698  -11.74824 1.000 61.54000  ? 431 ILE A CG2 1 
ATOM   2154 C CD1 . ILE A 1 313 ? -37.89650 17.46810  -14.48854 1.000 57.16000  ? 431 ILE A CD1 1 
ATOM   2155 N N   . THR A 1 314 ? -41.78029 20.04029  -10.90174 1.000 91.19000  ? 432 THR A N   1 
ATOM   2156 C CA  . THR A 1 314 ? -42.03192 21.03957  -9.85820  1.000 96.88000  ? 432 THR A CA  1 
ATOM   2157 C C   . THR A 1 314 ? -41.26804 20.75614  -8.55823  1.000 98.23000  ? 432 THR A C   1 
ATOM   2158 O O   . THR A 1 314 ? -41.13758 21.62969  -7.69369  1.000 96.67000  ? 432 THR A O   1 
ATOM   2159 C CB  . THR A 1 314 ? -43.54303 21.13572  -9.54442  1.000 92.77000  ? 432 THR A CB  1 
ATOM   2160 O OG1 . THR A 1 314 ? -43.76265 22.12102  -8.52389  1.000 103.38000 ? 432 THR A OG1 1 
ATOM   2161 C CG2 . THR A 1 314 ? -44.10151 19.78322  -9.10932  1.000 88.80000  ? 432 THR A CG2 1 
ATOM   2162 N N   . SER A 1 327 ? -50.51636 30.39697  -13.46927 1.000 71.38000  ? 445 SER A N   1 
ATOM   2163 C CA  . SER A 1 327 ? -50.17248 31.18983  -14.67874 1.000 98.10000  ? 445 SER A CA  1 
ATOM   2164 C C   . SER A 1 327 ? -49.05004 30.50479  -15.46694 1.000 97.70000  ? 445 SER A C   1 
ATOM   2165 O O   . SER A 1 327 ? -47.98004 30.27692  -14.89687 1.000 89.73000  ? 445 SER A O   1 
ATOM   2166 C CB  . SER A 1 327 ? -49.80117 32.59678  -14.31185 1.000 95.00000  ? 445 SER A CB  1 
ATOM   2167 O OG  . SER A 1 327 ? -49.86533 33.44342  -15.44636 1.000 95.00000  ? 445 SER A OG  1 
ATOM   2168 N N   . LEU A 1 328 ? -49.26669 30.26545  -16.76212 1.000 99.47000  ? 446 LEU A N   1 
ATOM   2169 C CA  . LEU A 1 328 ? -48.26423 29.57139  -17.61434 1.000 96.24000  ? 446 LEU A CA  1 
ATOM   2170 C C   . LEU A 1 328 ? -46.97057 30.38401  -17.69263 1.000 90.89000  ? 446 LEU A C   1 
ATOM   2171 O O   . LEU A 1 328 ? -45.90428 29.75452  -17.77080 1.000 85.30000  ? 446 LEU A O   1 
ATOM   2172 C CB  . LEU A 1 328 ? -48.84185 29.30196  -19.00961 1.000 30.00000  ? 446 LEU A CB  1 
ATOM   2173 N N   . THR A 1 329 ? -47.06016 31.71195  -17.66886 1.000 89.55000  ? 447 THR A N   1 
ATOM   2174 C CA  . THR A 1 329 ? -45.84651 32.54852  -17.72615 1.000 86.56000  ? 447 THR A CA  1 
ATOM   2175 C C   . THR A 1 329 ? -45.24079 32.59698  -16.35001 1.000 84.19000  ? 447 THR A C   1 
ATOM   2176 O O   . THR A 1 329 ? -44.00082 32.62946  -16.24976 1.000 74.75000  ? 447 THR A O   1 
ATOM   2177 C CB  . THR A 1 329 ? -46.20303 33.94366  -18.23039 1.000 93.92000  ? 447 THR A CB  1 
ATOM   2178 O OG1 . THR A 1 329 ? -47.32035 34.33771  -17.44237 1.000 91.25000  ? 447 THR A OG1 1 
ATOM   2179 C CG2 . THR A 1 329 ? -46.56876 33.95436  -19.70245 1.000 89.71000  ? 447 THR A CG2 1 
ATOM   2180 N N   . GLU A 1 330 ? -46.08397 32.57800  -15.32217 1.000 82.66000  ? 448 GLU A N   1 
ATOM   2181 C CA  . GLU A 1 330 ? -45.59629 32.71440  -13.92700 1.000 76.85000  ? 448 GLU A CA  1 
ATOM   2182 C C   . GLU A 1 330 ? -45.02180 31.39335  -13.42267 1.000 68.57000  ? 448 GLU A C   1 
ATOM   2183 O O   . GLU A 1 330 ? -44.35900 31.41504  -12.39754 1.000 74.64000  ? 448 GLU A O   1 
ATOM   2184 C CB  . GLU A 1 330 ? -46.70668 33.20737  -13.00092 1.000 75.39000  ? 448 GLU A CB  1 
ATOM   2185 N N   . ARG A 1 331 ? -45.28319 30.29064  -14.11137 1.000 62.39000  ? 449 ARG A N   1 
ATOM   2186 C CA  . ARG A 1 331 ? -44.74171 28.99161  -13.65203 1.000 68.09000  ? 449 ARG A CA  1 
ATOM   2187 C C   . ARG A 1 331 ? -43.52440 28.64164  -14.50501 1.000 70.14000  ? 449 ARG A C   1 
ATOM   2188 O O   . ARG A 1 331 ? -42.87701 27.63176  -14.21849 1.000 66.58000  ? 449 ARG A O   1 
ATOM   2189 C CB  . ARG A 1 331 ? -45.81422 27.90820  -13.75187 1.000 69.76000  ? 449 ARG A CB  1 
ATOM   2190 N N   . HIS A 1 332 ? -43.22958 29.47935  -15.49447 1.000 59.17000  ? 450 HIS A N   1 
ATOM   2191 C CA  . HIS A 1 332 ? -42.09331 29.25639  -16.41239 1.000 56.78000  ? 450 HIS A CA  1 
ATOM   2192 C C   . HIS A 1 332 ? -41.30486 30.55279  -16.50848 1.000 59.16000  ? 450 HIS A C   1 
ATOM   2193 O O   . HIS A 1 332 ? -41.22291 31.11046  -17.58914 1.000 58.96000  ? 450 HIS A O   1 
ATOM   2194 C CB  . HIS A 1 332 ? -42.63988 28.83495  -17.77574 1.000 58.39000  ? 450 HIS A CB  1 
ATOM   2195 C CG  . HIS A 1 332 ? -43.39632 27.55260  -17.74563 1.000 59.64000  ? 450 HIS A CG  1 
ATOM   2196 N ND1 . HIS A 1 332 ? -44.74133 27.49491  -17.56991 1.000 63.54000  ? 450 HIS A ND1 1 
ATOM   2197 C CD2 . HIS A 1 332 ? -42.99474 26.27985  -17.86430 1.000 56.70000  ? 450 HIS A CD2 1 
ATOM   2198 C CE1 . HIS A 1 332 ? -45.13778 26.25374  -17.57771 1.000 62.71000  ? 450 HIS A CE1 1 
ATOM   2199 N NE2 . HIS A 1 332 ? -44.09542 25.49730  -17.75997 1.000 58.64000  ? 450 HIS A NE2 1 
ATOM   2200 N N   . LYS A 1 333 ? -40.72626 30.98140  -15.39912 1.000 57.45000  ? 451 LYS A N   1 
ATOM   2201 C CA  . LYS A 1 333 ? -40.01883 32.27868  -15.36323 1.000 49.56000  ? 451 LYS A CA  1 
ATOM   2202 C C   . LYS A 1 333 ? -38.74166 32.24673  -16.19601 1.000 51.30000  ? 451 LYS A C   1 
ATOM   2203 O O   . LYS A 1 333 ? -38.44100 33.25821  -16.78836 1.000 52.37000  ? 451 LYS A O   1 
ATOM   2204 C CB  . LYS A 1 333 ? -39.80929 32.71493  -13.91593 1.000 51.51000  ? 451 LYS A CB  1 
ATOM   2205 C CG  . LYS A 1 333 ? -40.93776 33.55209  -13.33865 1.000 59.49000  ? 451 LYS A CG  1 
ATOM   2206 C CD  . LYS A 1 333 ? -41.14696 33.36613  -11.85380 1.000 58.07000  ? 451 LYS A CD  1 
ATOM   2207 N N   . ILE A 1 334 ? -38.01917 31.13507  -16.23253 1.000 49.24000  ? 452 ILE A N   1 
ATOM   2208 C CA  . ILE A 1 334 ? -36.77401 31.11810  -17.04631 1.000 48.78000  ? 452 ILE A CA  1 
ATOM   2209 C C   . ILE A 1 334 ? -37.15878 31.22279  -18.52132 1.000 50.18000  ? 452 ILE A C   1 
ATOM   2210 O O   . ILE A 1 334 ? -36.61803 32.06944  -19.21172 1.000 45.99000  ? 452 ILE A O   1 
ATOM   2211 C CB  . ILE A 1 334 ? -35.95451 29.85728  -16.74990 1.000 45.67000  ? 452 ILE A CB  1 
ATOM   2212 C CG1 . ILE A 1 334 ? -35.72172 29.68950  -15.25496 1.000 49.65000  ? 452 ILE A CG1 1 
ATOM   2213 C CG2 . ILE A 1 334 ? -34.65838 29.86830  -17.51765 1.000 37.76000  ? 452 ILE A CG2 1 
ATOM   2214 C CD1 . ILE A 1 334 ? -34.82628 28.54369  -14.90546 1.000 41.44000  ? 452 ILE A CD1 1 
ATOM   2215 N N   . LEU A 1 335 ? -38.07233 30.37966  -18.97898 1.000 46.24000  ? 453 LEU A N   1 
ATOM   2216 C CA  . LEU A 1 335 ? -38.47710 30.44831  -20.38202 1.000 45.95000  ? 453 LEU A CA  1 
ATOM   2217 C C   . LEU A 1 335 ? -38.95964 31.83031  -20.74530 1.000 48.32000  ? 453 LEU A C   1 
ATOM   2218 O O   . LEU A 1 335 ? -38.56969 32.37709  -21.78190 1.000 53.49000  ? 453 LEU A O   1 
ATOM   2219 C CB  . LEU A 1 335 ? -39.57560 29.44001  -20.70281 1.000 45.81000  ? 453 LEU A CB  1 
ATOM   2220 C CG  . LEU A 1 335 ? -39.15794 27.99830  -20.87258 1.000 45.14000  ? 453 LEU A CG  1 
ATOM   2221 C CD1 . LEU A 1 335 ? -40.38153 27.12884  -21.01332 1.000 47.82000  ? 453 LEU A CD1 1 
ATOM   2222 C CD2 . LEU A 1 335 ? -38.32169 27.95740  -22.13345 1.000 44.84000  ? 453 LEU A CD2 1 
ATOM   2223 N N   . HIS A 1 336 ? -39.81705 32.41044  -19.90311 1.000 48.10000  ? 454 HIS A N   1 
ATOM   2224 C CA  . HIS A 1 336 ? -40.32958 33.74339  -20.19343 1.000 55.21000  ? 454 HIS A CA  1 
ATOM   2225 C C   . HIS A 1 336 ? -39.18999 34.74898  -20.35562 1.000 57.24000  ? 454 HIS A C   1 
ATOM   2226 O O   . HIS A 1 336 ? -39.14413 35.48958  -21.34518 1.000 59.35000  ? 454 HIS A O   1 
ATOM   2227 C CB  . HIS A 1 336 ? -41.31098 34.18832  -19.10935 1.000 60.29000  ? 454 HIS A CB  1 
ATOM   2228 C CG  . HIS A 1 336 ? -42.04346 35.44421  -19.46174 1.000 73.07000  ? 454 HIS A CG  1 
ATOM   2229 N ND1 . HIS A 1 336 ? -43.31736 35.43896  -19.98798 1.000 81.65000  ? 454 HIS A ND1 1 
ATOM   2230 C CD2 . HIS A 1 336 ? -41.66404 36.74534  -19.40491 1.000 79.58000  ? 454 HIS A CD2 1 
ATOM   2231 C CE1 . HIS A 1 336 ? -43.69686 36.68493  -20.22332 1.000 81.62000  ? 454 HIS A CE1 1 
ATOM   2232 N NE2 . HIS A 1 336 ? -42.71328 37.49616  -19.87766 1.000 76.20000  ? 454 HIS A NE2 1 
ATOM   2233 N N   . ARG A 1 337 ? -38.24418 34.77084  -19.40744 1.000 55.57000  ? 455 ARG A N   1 
ATOM   2234 C CA  A ARG A 1 337 ? -37.10855 35.67841  -19.53069 0.580 55.99000  ? 455 ARG A CA  1 
ATOM   2235 C CA  B ARG A 1 337 ? -37.10655 35.67741  -19.52869 0.420 56.02000  ? 455 ARG A CA  1 
ATOM   2236 C C   . ARG A 1 337 ? -36.30719 35.39250  -20.79171 1.000 58.91000  ? 455 ARG A C   1 
ATOM   2237 O O   . ARG A 1 337 ? -35.87947 36.32210  -21.49009 1.000 61.16000  ? 455 ARG A O   1 
ATOM   2238 C CB  A ARG A 1 337 ? -36.20673 35.57409  -18.30559 0.580 58.44000  ? 455 ARG A CB  1 
ATOM   2239 C CB  B ARG A 1 337 ? -36.19873 35.57109  -18.30359 0.420 58.43000  ? 455 ARG A CB  1 
ATOM   2240 C CG  A ARG A 1 337 ? -34.81291 36.10286  -18.58802 0.580 60.93000  ? 455 ARG A CG  1 
ATOM   2241 C CG  B ARG A 1 337 ? -34.98712 36.49967  -18.38982 0.420 61.19000  ? 455 ARG A CG  1 
ATOM   2242 C CD  A ARG A 1 337 ? -33.74581 35.50181  -17.70218 0.580 62.03000  ? 455 ARG A CD  1 
ATOM   2243 C CD  B ARG A 1 337 ? -34.05830 36.39537  -17.18671 0.420 61.09000  ? 455 ARG A CD  1 
ATOM   2244 N NE  A ARG A 1 337 ? -32.71130 36.49110  -17.42040 0.580 63.55000  ? 455 ARG A NE  1 
ATOM   2245 N NE  B ARG A 1 337 ? -33.43674 35.07558  -17.07737 0.420 61.00000  ? 455 ARG A NE  1 
ATOM   2246 C CZ  A ARG A 1 337 ? -31.93049 36.48381  -16.34826 0.580 59.25000  ? 455 ARG A CZ  1 
ATOM   2247 C CZ  B ARG A 1 337 ? -32.39942 34.66246  -17.80242 0.420 60.50000  ? 455 ARG A CZ  1 
ATOM   2248 N NH1 A ARG A 1 337 ? -31.02294 37.43612  -16.19654 0.580 59.05000  ? 455 ARG A NH1 1 
ATOM   2249 N NH1 B ARG A 1 337 ? -31.91292 33.44356  -17.61905 0.420 58.59000  ? 455 ARG A NH1 1 
ATOM   2250 N NH2 A ARG A 1 337 ? -32.05424 35.53122  -15.43385 0.580 56.44000  ? 455 ARG A NH2 1 
ATOM   2251 N NH2 B ARG A 1 337 ? -31.85460 35.45124  -18.71986 0.420 61.55000  ? 455 ARG A NH2 1 
ATOM   2252 N N   . LEU A 1 338 ? -36.09257 34.10978  -21.09843 1.000 57.40000  ? 456 LEU A N   1 
ATOM   2253 C CA  . LEU A 1 338 ? -35.35519 33.73480  -22.30051 1.000 53.42000  ? 456 LEU A CA  1 
ATOM   2254 C C   . LEU A 1 338 ? -36.08614 34.16523  -23.57039 1.000 57.14000  ? 456 LEU A C   1 
ATOM   2255 O O   . LEU A 1 338 ? -35.44706 34.42012  -24.60113 1.000 59.72000  ? 456 LEU A O   1 
ATOM   2256 C CB  . LEU A 1 338 ? -35.11252 32.22591  -22.30235 1.000 50.39000  ? 456 LEU A CB  1 
ATOM   2257 C CG  . LEU A 1 338 ? -33.97245 31.68990  -21.43046 1.000 48.69000  ? 456 LEU A CG  1 
ATOM   2258 C CD1 . LEU A 1 338 ? -33.83476 30.16805  -21.58233 1.000 39.11000  ? 456 LEU A CD1 1 
ATOM   2259 C CD2 . LEU A 1 338 ? -32.66770 32.38966  -21.76081 1.000 42.42000  ? 456 LEU A CD2 1 
ATOM   2260 N N   . LEU A 1 339 ? -37.41619 34.26262  -23.52058 1.000 55.27000  ? 457 LEU A N   1 
ATOM   2261 C CA  . LEU A 1 339 ? -38.18814 34.64697  -24.69750 1.000 61.42000  ? 457 LEU A CA  1 
ATOM   2262 C C   . LEU A 1 339 ? -38.37578 36.15696  -24.81365 1.000 65.82000  ? 457 LEU A C   1 
ATOM   2263 O O   . LEU A 1 339 ? -38.56680 36.65853  -25.92539 1.000 71.32000  ? 457 LEU A O   1 
ATOM   2264 C CB  . LEU A 1 339 ? -39.54983 33.93536  -24.67717 1.000 53.61000  ? 457 LEU A CB  1 
ATOM   2265 C CG  . LEU A 1 339 ? -39.55011 32.44660  -25.08404 1.000 50.53000  ? 457 LEU A CG  1 
ATOM   2266 C CD1 . LEU A 1 339 ? -40.72491 31.72772  -24.46468 1.000 48.49000  ? 457 LEU A CD1 1 
ATOM   2267 C CD2 . LEU A 1 339 ? -39.56273 32.21649  -26.60218 1.000 46.79000  ? 457 LEU A CD2 1 
ATOM   2268 N N   . GLN A 1 340 ? -38.29531 36.89034  -23.69620 1.000 70.58000  ? 458 GLN A N   1 
ATOM   2269 C CA  . GLN A 1 340 ? -38.45795 38.34126  -23.69338 1.000 69.82000  ? 458 GLN A CA  1 
ATOM   2270 C C   . GLN A 1 340 ? -37.17221 39.08803  -24.03570 1.000 71.87000  ? 458 GLN A C   1 
ATOM   2271 O O   . GLN A 1 340 ? -37.24365 40.25722  -24.42203 1.000 84.25000  ? 458 GLN A O   1 
ATOM   2272 C CB  . GLN A 1 340 ? -38.98040 38.80623  -22.32720 1.000 66.52000  ? 458 GLN A CB  1 
ATOM   2273 N N   . GLU A 1 341 ? -36.00796 38.45446  -23.89786 1.000 77.45000  ? 459 GLU A N   1 
ATOM   2274 C CA  . GLU A 1 341 ? -34.75012 39.03128  -24.36529 1.000 80.15000  ? 459 GLU A CA  1 
ATOM   2275 C C   . GLU A 1 341 ? -34.69684 39.03421  -25.89728 1.000 88.59000  ? 459 GLU A C   1 
ATOM   2276 O O   . GLU A 1 341 ? -35.51044 38.39425  -26.57580 1.000 88.51000  ? 459 GLU A O   1 
ATOM   2277 C CB  . GLU A 1 341 ? -33.56188 38.23549  -23.82654 1.000 78.40000  ? 459 GLU A CB  1 
ATOM   2278 C CG  . GLU A 1 341 ? -33.29021 38.36273  -22.34041 1.000 75.58000  ? 459 GLU A CG  1 
ATOM   2279 C CD  . GLU A 1 341 ? -32.36481 37.25286  -21.86089 1.000 78.70000  ? 459 GLU A CD  1 
ATOM   2280 O OE1 . GLU A 1 341 ? -31.99728 36.39952  -22.71033 1.000 78.26000  ? 459 GLU A OE1 1 
ATOM   2281 O OE2 . GLU A 1 341 ? -32.01702 37.21830  -20.65285 1.000 71.81000  ? 459 GLU A OE2 1 
ATOM   2282 N N   . GLY A 1 342 ? -33.70605 39.74796  -26.44268 1.000 98.44000  ? 460 GLY A N   1 
ATOM   2283 C CA  . GLY A 1 342 ? -33.50683 39.83390  -27.88659 1.000 88.04000  ? 460 GLY A CA  1 
ATOM   2284 C C   . GLY A 1 342 ? -32.99714 38.54249  -28.51625 1.000 86.98000  ? 460 GLY A C   1 
ATOM   2285 O O   . GLY A 1 342 ? -33.57673 38.01580  -29.47567 1.000 77.38000  ? 460 GLY A O   1 
ATOM   2286 N N   . LEU B 1 25  ? 19.98931  -21.27450 7.16143   1.000 62.12000  ? 143 LEU B N   1 
ATOM   2287 C CA  . LEU B 1 25  ? 19.54847  -19.90845 7.42944   1.000 65.92000  ? 143 LEU B CA  1 
ATOM   2288 C C   . LEU B 1 25  ? 19.52214  -19.68224 8.95442   1.000 63.41000  ? 143 LEU B C   1 
ATOM   2289 O O   . LEU B 1 25  ? 18.72643  -20.30812 9.66085   1.000 63.57000  ? 143 LEU B O   1 
ATOM   2290 C CB  . LEU B 1 25  ? 18.16421  -19.67749 6.81501   1.000 65.38000  ? 143 LEU B CB  1 
ATOM   2291 C CG  . LEU B 1 25  ? 17.73210  -18.25452 6.47401   1.000 61.73000  ? 143 LEU B CG  1 
ATOM   2292 C CD1 . LEU B 1 25  ? 18.62462  -17.77570 5.33956   1.000 60.78000  ? 143 LEU B CD1 1 
ATOM   2293 C CD2 . LEU B 1 25  ? 16.27891  -18.17853 6.03464   1.000 58.22000  ? 143 LEU B CD2 1 
ATOM   2294 N N   . THR B 1 26  ? 20.38639  -18.80620 9.47293   1.000 62.56000  ? 144 THR B N   1 
ATOM   2295 C CA  . THR B 1 26  ? 20.58703  -18.75201 10.91483  1.000 57.45000  ? 144 THR B CA  1 
ATOM   2296 C C   . THR B 1 26  ? 19.35534  -18.15589 11.58229  1.000 68.49000  ? 144 THR B C   1 
ATOM   2297 O O   . THR B 1 26  ? 18.36206  -17.80494 10.93268  1.000 69.23000  ? 144 THR B O   1 
ATOM   2298 C CB  . THR B 1 26  ? 21.81222  -17.92000 11.30519  1.000 58.28000  ? 144 THR B CB  1 
ATOM   2299 O OG1 . THR B 1 26  ? 21.61912  -16.55104 10.98209  1.000 58.98000  ? 144 THR B OG1 1 
ATOM   2300 C CG2 . THR B 1 26  ? 23.04488  -18.40913 10.56571  1.000 57.68000  ? 144 THR B CG2 1 
ATOM   2301 N N   . GLU B 1 27  ? 19.42592  -18.01671 12.90624  1.000 70.76000  ? 145 GLU B N   1 
ATOM   2302 C CA  . GLU B 1 27  ? 18.29724  -17.43158 13.61066  1.000 63.57000  ? 145 GLU B CA  1 
ATOM   2303 C C   . GLU B 1 27  ? 18.29623  -15.91360 13.47045  1.000 64.51000  ? 145 GLU B C   1 
ATOM   2304 O O   . GLU B 1 27  ? 17.24813  -15.31761 13.20783  1.000 61.25000  ? 145 GLU B O   1 
ATOM   2305 C CB  . GLU B 1 27  ? 18.30687  -17.86239 15.07771  1.000 69.76000  ? 145 GLU B CB  1 
ATOM   2306 C CG  . GLU B 1 27  ? 16.96919  -17.61025 15.78226  1.000 79.91000  ? 145 GLU B CG  1 
ATOM   2307 C CD  . GLU B 1 27  ? 15.81091  -18.43629 15.21188  1.000 84.40000  ? 145 GLU B CD  1 
ATOM   2308 O OE1 . GLU B 1 27  ? 16.03469  -19.59836 14.79493  1.000 85.71000  ? 145 GLU B OE1 1 
ATOM   2309 O OE2 . GLU B 1 27  ? 14.67490  -17.90527 15.15530  1.000 81.78000  ? 145 GLU B OE2 1 
ATOM   2310 N N   . GLU B 1 28  ? 19.46131  -15.26662 13.60886  1.000 73.56000  ? 146 GLU B N   1 
ATOM   2311 C CA  . GLU B 1 28  ? 19.50526  -13.81965 13.39865  1.000 67.84000  ? 146 GLU B CA  1 
ATOM   2312 C C   . GLU B 1 28  ? 19.07565  -13.45883 11.97879  1.000 61.41000  ? 146 GLU B C   1 
ATOM   2313 O O   . GLU B 1 28  ? 18.55759  -12.36084 11.75386  1.000 60.12000  ? 146 GLU B O   1 
ATOM   2314 C CB  . GLU B 1 28  ? 20.90441  -13.25965 13.70396  1.000 44.89000  ? 146 GLU B CB  1 
ATOM   2315 N N   . GLN B 1 29  ? 19.25420  -14.37796 11.01583  1.000 61.09000  ? 147 GLN B N   1 
ATOM   2316 C CA  . GLN B 1 29  ? 18.84461  -14.12313 9.63197   1.000 58.44000  ? 147 GLN B CA  1 
ATOM   2317 C C   . GLN B 1 29  ? 17.34352  -14.28511 9.44665   1.000 58.62000  ? 147 GLN B C   1 
ATOM   2318 O O   . GLN B 1 29  ? 16.71328  -13.41217 8.84081   1.000 52.66000  ? 147 GLN B O   1 
ATOM   2319 C CB  . GLN B 1 29  ? 19.61716  -15.02428 8.66376   1.000 52.85000  ? 147 GLN B CB  1 
ATOM   2320 C CG  . GLN B 1 29  ? 21.13322  -14.82131 8.80507   1.000 62.76000  ? 147 GLN B CG  1 
ATOM   2321 C CD  . GLN B 1 29  ? 21.98379  -15.67946 7.87981   1.000 62.28000  ? 147 GLN B CD  1 
ATOM   2322 O OE1 . GLN B 1 29  ? 21.71267  -16.87648 7.68909   1.000 52.44000  ? 147 GLN B OE1 1 
ATOM   2323 N NE2 . GLN B 1 29  ? 23.08860  -15.09956 7.39125   1.000 52.83000  ? 147 GLN B NE2 1 
ATOM   2324 N N   . ARG B 1 30  ? 16.75571  -15.37602 9.96705   1.000 59.73000  ? 148 ARG B N   1 
ATOM   2325 C CA  . ARG B 1 30  ? 15.29573  -15.48897 10.01171  1.000 57.52000  ? 148 ARG B CA  1 
ATOM   2326 C C   . ARG B 1 30  ? 14.66403  -14.23887 10.61282  1.000 55.42000  ? 148 ARG B C   1 
ATOM   2327 O O   . ARG B 1 30  ? 13.71380  -13.68292 10.05116  1.000 53.66000  ? 148 ARG B O   1 
ATOM   2328 C CB  . ARG B 1 30  ? 14.85004  -16.72985 10.80507  1.000 64.84000  ? 148 ARG B CB  1 
ATOM   2329 C CG  . ARG B 1 30  ? 15.09370  -18.07495 10.13014  1.000 67.20000  ? 148 ARG B CG  1 
ATOM   2330 C CD  . ARG B 1 30  ? 14.76208  -19.23582 11.06544  1.000 78.20000  ? 148 ARG B CD  1 
ATOM   2331 N NE  . ARG B 1 30  ? 13.33921  -19.36673 11.37208  1.000 88.06000  ? 148 ARG B NE  1 
ATOM   2332 C CZ  . ARG B 1 30  ? 12.86162  -20.09358 12.38038  1.000 79.19000  ? 148 ARG B CZ  1 
ATOM   2333 N NH1 . ARG B 1 30  ? 11.55471  -20.17652 12.58397  1.000 75.42000  ? 148 ARG B NH1 1 
ATOM   2334 N NH2 . ARG B 1 30  ? 13.69797  -20.70950 13.20610  1.000 73.83000  ? 148 ARG B NH2 1 
ATOM   2335 N N   . MET B 1 31  ? 15.17155  -13.78874 11.76553  1.000 52.42000  ? 149 MET B N   1 
ATOM   2336 C CA  . MET B 1 31  ? 14.61786  -12.58764 12.38562  1.000 65.21000  ? 149 MET B CA  1 
ATOM   2337 C C   . MET B 1 31  ? 14.70848  -11.40177 11.43342  1.000 60.16000  ? 149 MET B C   1 
ATOM   2338 O O   . MET B 1 31  ? 13.76945  -10.60175 11.31172  1.000 57.27000  ? 149 MET B O   1 
ATOM   2339 C CB  . MET B 1 31  ? 15.34144  -12.28248 13.70626  1.000 57.45000  ? 149 MET B CB  1 
ATOM   2340 N N   . MET B 1 32  ? 15.82517  -11.29989 10.72092  1.000 57.82000  ? 150 MET B N   1 
ATOM   2341 C CA  . MET B 1 32  ? 16.06083  -10.15302 9.86066   1.000 56.85000  ? 150 MET B CA  1 
ATOM   2342 C C   . MET B 1 32  ? 15.06133  -10.11814 8.71009   1.000 47.69000  ? 150 MET B C   1 
ATOM   2343 O O   . MET B 1 32  ? 14.47123  -9.07216  8.42421   1.000 41.40000  ? 150 MET B O   1 
ATOM   2344 C CB  . MET B 1 32  ? 17.51262  -10.20612 9.38503   1.000 50.46000  ? 150 MET B CB  1 
ATOM   2345 C CG  . MET B 1 32  ? 17.90317  -9.24628  8.29373   1.000 58.76000  ? 150 MET B CG  1 
ATOM   2346 S SD  . MET B 1 32  ? 19.71510  -9.23336  8.13894   1.000 66.42000  ? 150 MET B SD  1 
ATOM   2347 C CE  . MET B 1 32  ? 20.19286  -9.10214  9.87072   1.000 66.25000  ? 150 MET B CE  1 
ATOM   2348 N N   . ILE B 1 33  ? 14.80203  -11.26021 8.10136   1.000 48.58000  ? 151 ILE B N   1 
ATOM   2349 C CA  . ILE B 1 33  ? 13.85653  -11.28534 6.95877   1.000 46.24000  ? 151 ILE B CA  1 
ATOM   2350 C C   . ILE B 1 33  ? 12.45276  -10.98023 7.46435   1.000 46.10000  ? 151 ILE B C   1 
ATOM   2351 O O   . ILE B 1 33  ? 11.70446  -10.35830 6.74259   1.000 41.13000  ? 151 ILE B O   1 
ATOM   2352 C CB  . ILE B 1 33  ? 13.93517  -12.64044 6.24792   1.000 47.14000  ? 151 ILE B CB  1 
ATOM   2353 C CG1 . ILE B 1 33  ? 15.25685  -12.79657 5.51036   1.000 41.71000  ? 151 ILE B CG1 1 
ATOM   2354 C CG2 . ILE B 1 33  ? 12.76076  -12.83252 5.31346   1.000 46.18000  ? 151 ILE B CG2 1 
ATOM   2355 C CD1 . ILE B 1 33  ? 15.36849  -14.09567 4.78549   1.000 42.80000  ? 151 ILE B CD1 1 
ATOM   2356 N N   . ARG B 1 34  ? 12.14227  -11.40406 8.68054   1.000 49.77000  ? 152 ARG B N   1 
ATOM   2357 C CA  . ARG B 1 34  ? 10.81555  -11.18393 9.30909   1.000 51.23000  ? 152 ARG B CA  1 
ATOM   2358 C C   . ARG B 1 34  ? 10.60069  -9.68990  9.52598   1.000 49.79000  ? 152 ARG B C   1 
ATOM   2359 O O   . ARG B 1 34  ? 9.51460   -9.20590  9.27139   1.000 42.96000  ? 152 ARG B O   1 
ATOM   2360 C CB  . ARG B 1 34  ? 10.77813  -11.86575 10.67819  1.000 57.97000  ? 152 ARG B CB  1 
ATOM   2361 C CG  . ARG B 1 34  ? 10.11710  -13.23472 10.70767  1.000 70.03000  ? 152 ARG B CG  1 
ATOM   2362 N N   . GLU B 1 35  ? 11.61594  -9.01086  10.03345  1.000 49.32000  ? 153 GLU B N   1 
ATOM   2363 C CA  . GLU B 1 35  ? 11.53009  -7.55782  10.28029  1.000 46.52000  ? 153 GLU B CA  1 
ATOM   2364 C C   . GLU B 1 35  ? 11.35553  -6.82700  8.95027   1.000 45.32000  ? 153 GLU B C   1 
ATOM   2365 O O   . GLU B 1 35  ? 10.56354  -5.91298  8.91249   1.000 43.42000  ? 153 GLU B O   1 
ATOM   2366 C CB  . GLU B 1 35  ? 12.75444  -7.08776  11.06169  1.000 49.23000  ? 153 GLU B CB  1 
ATOM   2367 C CG  . GLU B 1 35  ? 13.01342  -5.60678  10.91338  1.000 55.88000  ? 153 GLU B CG  1 
ATOM   2368 C CD  . GLU B 1 35  ? 13.44999  -4.85163  12.14809  1.000 63.10000  ? 153 GLU B CD  1 
ATOM   2369 O OE1 . GLU B 1 35  ? 14.55018  -5.09060  12.61464  1.000 73.89000  ? 153 GLU B OE1 1 
ATOM   2370 O OE2 . GLU B 1 35  ? 12.69721  -4.01555  12.61331  1.000 55.58000  ? 153 GLU B OE2 1 
ATOM   2371 N N   . LEU B 1 36  ? 12.06106  -7.23716  7.90102   1.000 42.27000  ? 154 LEU B N   1 
ATOM   2372 C CA  . LEU B 1 36  ? 11.93152  -6.53932  6.61998   1.000 39.28000  ? 154 LEU B CA  1 
ATOM   2373 C C   . LEU B 1 36  ? 10.55026  -6.76136  6.03161   1.000 41.13000  ? 154 LEU B C   1 
ATOM   2374 O O   . LEU B 1 36  ? 9.87510   -5.81040  5.61178   1.000 36.28000  ? 154 LEU B O   1 
ATOM   2375 C CB  . LEU B 1 36  ? 12.98908  -7.01549  5.63158   1.000 33.44000  ? 154 LEU B CB  1 
ATOM   2376 C CG  . LEU B 1 36  ? 14.43722  -6.63249  5.94090   1.000 40.10000  ? 154 LEU B CG  1 
ATOM   2377 C CD1 . LEU B 1 36  ? 15.35073  -7.16567  4.84157   1.000 29.95000  ? 154 LEU B CD1 1 
ATOM   2378 C CD2 . LEU B 1 36  ? 14.63938  -5.11546  6.18861   1.000 29.11000  ? 154 LEU B CD2 1 
ATOM   2379 N N   . MET B 1 37  ? 10.12320  -8.02935  5.99497   1.000 39.40000  ? 155 MET B N   1 
ATOM   2380 C CA  . MET B 1 37  ? 8.81995   -8.39539  5.45159   1.000 34.00000  ? 155 MET B CA  1 
ATOM   2381 C C   . MET B 1 37  ? 7.69331   -7.73625  6.22099   1.000 41.37000  ? 155 MET B C   1 
ATOM   2382 O O   . MET B 1 37  ? 6.73706   -7.22930  5.61934   1.000 45.09000  ? 155 MET B O   1 
ATOM   2383 C CB  . MET B 1 37  ? 8.67392   -9.91838  5.47085   1.000 41.52000  ? 155 MET B CB  1 
ATOM   2384 C CG  . MET B 1 37  ? 9.50043   -10.64755 4.41659   1.000 47.41000  ? 155 MET B CG  1 
ATOM   2385 S SD  . MET B 1 37  ? 9.08272   -10.05276 2.74969   1.000 51.68000  ? 155 MET B SD  1 
ATOM   2386 C CE  . MET B 1 37  ? 7.66857   -11.12675 2.45945   1.000 54.13000  ? 155 MET B CE  1 
ATOM   2387 N N   . ASP B 1 38  ? 7.77289   -7.75107  7.55296   1.000 41.13000  ? 156 ASP B N   1 
ATOM   2388 C CA  . ASP B 1 38  ? 6.78426   -7.03794  8.34529   1.000 39.04000  ? 156 ASP B CA  1 
ATOM   2389 C C   . ASP B 1 38  ? 6.72912   -5.57699  7.92512   1.000 44.14000  ? 156 ASP B C   1 
ATOM   2390 O O   . ASP B 1 38  ? 5.64602   -5.03499  7.66552   1.000 46.31000  ? 156 ASP B O   1 
ATOM   2391 C CB  . ASP B 1 38  ? 7.11090   -7.19475  9.83217   1.000 41.48000  ? 156 ASP B CB  1 
ATOM   2392 C CG  . ASP B 1 38  ? 6.09131   -6.53960  10.72653  1.000 45.76000  ? 156 ASP B CG  1 
ATOM   2393 O OD1 . ASP B 1 38  ? 4.91931   -6.97656  10.74010  1.000 46.32000  ? 156 ASP B OD1 1 
ATOM   2394 O OD2 . ASP B 1 38  ? 6.46664   -5.56252  11.40324  1.000 58.30000  ? 156 ASP B OD2 1 
ATOM   2395 N N   . ALA B 1 39  ? 7.90107   -4.95105  7.76853   1.000 43.62000  ? 157 ALA B N   1 
ATOM   2396 C CA  . ALA B 1 39  ? 7.95996   -3.53710  7.41731   1.000 37.53000  ? 157 ALA B CA  1 
ATOM   2397 C C   . ALA B 1 39  ? 7.35737   -3.27026  6.04654   1.000 38.86000  ? 157 ALA B C   1 
ATOM   2398 O O   . ALA B 1 39  ? 6.63632   -2.28526  5.87072   1.000 42.54000  ? 157 ALA B O   1 
ATOM   2399 C CB  . ALA B 1 39  ? 9.40300   -3.05313  7.47862   1.000 40.65000  ? 157 ALA B CB  1 
ATOM   2400 N N   . GLN B 1 40  ? 7.65491   -4.12540  5.05752   1.000 41.81000  ? 158 GLN B N   1 
ATOM   2401 C CA  . GLN B 1 40  ? 7.07933   -3.97856  3.71976   1.000 33.96000  ? 158 GLN B CA  1 
ATOM   2402 C C   . GLN B 1 40  ? 5.55736   -3.99251  3.78642   1.000 41.27000  ? 158 GLN B C   1 
ATOM   2403 O O   . GLN B 1 40  ? 4.88614   -3.11456  3.22560   1.000 46.63000  ? 158 GLN B O   1 
ATOM   2404 C CB  . GLN B 1 40  ? 7.55390   -5.11570  2.80270   1.000 41.75000  ? 158 GLN B CB  1 
ATOM   2405 C CG  . GLN B 1 40  ? 7.23625   -4.91489  1.30181   1.000 37.70000  ? 158 GLN B CG  1 
ATOM   2406 C CD  . GLN B 1 40  ? 8.25697   -4.04102  0.60425   1.000 43.09000  ? 158 GLN B CD  1 
ATOM   2407 O OE1 . GLN B 1 40  ? 8.14999   -2.81302  0.57313   1.000 49.26000  ? 158 GLN B OE1 1 
ATOM   2408 N NE2 . GLN B 1 40  ? 9.18065   -4.68614  -0.07707  1.000 48.52000  ? 158 GLN B NE2 1 
ATOM   2409 N N   . MET B 1 41  ? 5.00163   -5.00740  4.46180   1.000 41.45000  ? 159 MET B N   1 
ATOM   2410 C CA  . MET B 1 41  ? 3.55571   -5.14633  4.66445   1.000 40.16000  ? 159 MET B CA  1 
ATOM   2411 C C   . MET B 1 41  ? 2.91500   -3.87824  5.23156   1.000 42.82000  ? 159 MET B C   1 
ATOM   2412 O O   . MET B 1 41  ? 1.81782   -3.48426  4.81099   1.000 47.22000  ? 159 MET B O   1 
ATOM   2413 C CB  . MET B 1 41  ? 3.31208   -6.35320  5.58672   1.000 41.80000  ? 159 MET B CB  1 
ATOM   2414 C CG  . MET B 1 41  ? 1.87524   -6.68210  5.98139   1.000 40.06000  ? 159 MET B CG  1 
ATOM   2415 S SD  . MET B 1 41  ? 1.27089   -5.78789  7.42153   1.000 44.86000  ? 159 MET B SD  1 
ATOM   2416 C CE  . MET B 1 41  ? 2.17645   -6.55974  8.75924   1.000 33.19000  ? 159 MET B CE  1 
ATOM   2417 N N   . LYS B 1 42  ? 3.58643   -3.22013  6.18018   1.000 38.78000  ? 160 LYS B N   1 
ATOM   2418 C CA  . LYS B 1 42  ? 2.99776   -2.06902  6.85328   1.000 44.93000  ? 160 LYS B CA  1 
ATOM   2419 C C   . LYS B 1 42  ? 3.09245   -0.77013  6.06707   1.000 42.16000  ? 160 LYS B C   1 
ATOM   2420 O O   . LYS B 1 42  ? 2.40964   0.19694   6.43024   1.000 41.58000  ? 160 LYS B O   1 
ATOM   2421 C CB  . LYS B 1 42  ? 3.66236   -1.85486  8.21296   1.000 39.21000  ? 160 LYS B CB  1 
ATOM   2422 C CG  . LYS B 1 42  ? 3.32176   -2.90072  9.19825   1.000 42.88000  ? 160 LYS B CG  1 
ATOM   2423 C CD  . LYS B 1 42  ? 3.98834   -2.62556  10.51592  1.000 46.96000  ? 160 LYS B CD  1 
ATOM   2424 C CE  . LYS B 1 42  ? 3.81271   -3.80543  11.43916  1.000 48.38000  ? 160 LYS B CE  1 
ATOM   2425 N NZ  . LYS B 1 42  ? 4.63625   -3.63330  12.65778  1.000 65.01000  ? 160 LYS B NZ  1 
ATOM   2426 N N   . THR B 1 43  ? 3.93000   -0.70529  5.03069   1.000 41.35000  ? 161 THR B N   1 
ATOM   2427 C CA  . THR B 1 43  ? 4.26978   0.57461   4.42337   1.000 41.85000  ? 161 THR B CA  1 
ATOM   2428 C C   . THR B 1 43  ? 4.15212   0.56142   2.91643   1.000 40.33000  ? 161 THR B C   1 
ATOM   2429 O O   . THR B 1 43  ? 4.53187   1.54632   2.27613   1.000 43.65000  ? 161 THR B O   1 
ATOM   2430 C CB  . THR B 1 43  ? 5.70295   1.00662   4.78969   1.000 42.34000  ? 161 THR B CB  1 
ATOM   2431 O OG1 . THR B 1 43  ? 6.64070   0.05252   4.27541   1.000 43.96000  ? 161 THR B OG1 1 
ATOM   2432 C CG2 . THR B 1 43  ? 5.88061   1.10482   6.29460   1.000 40.48000  ? 161 THR B CG2 1 
ATOM   2433 N N   . PHE B 1 44  ? 3.68383   -0.53065  2.33178   1.000 43.21000  ? 162 PHE B N   1 
ATOM   2434 C CA  . PHE B 1 44  ? 3.51220   -0.63383  0.88687   1.000 43.02000  ? 162 PHE B CA  1 
ATOM   2435 C C   . PHE B 1 44  ? 2.03109   -0.85082  0.65554   1.000 39.36000  ? 162 PHE B C   1 
ATOM   2436 O O   . PHE B 1 44  ? 1.51713   -1.95278  0.83291   1.000 41.62000  ? 162 PHE B O   1 
ATOM   2437 C CB  . PHE B 1 44  ? 4.36191   -1.75794  0.29964   1.000 40.94000  ? 162 PHE B CB  1 
ATOM   2438 C CG  . PHE B 1 44  ? 4.39025   -1.78514  -1.21136  1.000 38.65000  ? 162 PHE B CG  1 
ATOM   2439 C CD1 . PHE B 1 44  ? 3.80795   -0.77422  -1.95625  1.000 42.15000  ? 162 PHE B CD1 1 
ATOM   2440 C CD2 . PHE B 1 44  ? 5.02092   -2.82525  -1.88250  1.000 40.10000  ? 162 PHE B CD2 1 
ATOM   2441 C CE1 . PHE B 1 44  ? 3.83134   -0.80741  -3.34825  1.000 44.42000  ? 162 PHE B CE1 1 
ATOM   2442 C CE2 . PHE B 1 44  ? 5.05032   -2.87844  -3.26751  1.000 36.40000  ? 162 PHE B CE2 1 
ATOM   2443 C CZ  . PHE B 1 44  ? 4.45403   -1.86852  -4.00338  1.000 44.91000  ? 162 PHE B CZ  1 
ATOM   2444 N N   . ASP B 1 45  ? 1.34298   0.22016   0.32170   1.000 46.41000  ? 163 ASP B N   1 
ATOM   2445 C CA  . ASP B 1 45  ? -0.06518  0.15815   -0.03768  1.000 50.07000  ? 163 ASP B CA  1 
ATOM   2446 C C   . ASP B 1 45  ? -0.13782  -0.35404  -1.46658  1.000 47.69000  ? 163 ASP B C   1 
ATOM   2447 O O   . ASP B 1 45  ? -0.05622  0.41283   -2.42772  1.000 53.10000  ? 163 ASP B O   1 
ATOM   2448 C CB  . ASP B 1 45  ? -0.68508  1.54019   0.09341   1.000 57.66000  ? 163 ASP B CB  1 
ATOM   2449 C CG  . ASP B 1 45  ? -2.17020  1.54420   -0.17194  1.000 62.16000  ? 163 ASP B CG  1 
ATOM   2450 O OD1 . ASP B 1 45  ? -2.83517  0.46923   -0.03451  1.000 53.83000  ? 163 ASP B OD1 1 
ATOM   2451 O OD2 . ASP B 1 45  ? -2.64932  2.64916   -0.52288  1.000 53.54000  ? 163 ASP B OD2 1 
ATOM   2452 N N   . THR B 1 46  ? -0.27993  -1.66306  -1.62634  1.000 47.47000  ? 164 THR B N   1 
ATOM   2453 C CA  . THR B 1 46  ? -0.22154  -2.23024  -2.97229  1.000 46.78000  ? 164 THR B CA  1 
ATOM   2454 C C   . THR B 1 46  ? -1.52587  -2.08730  -3.73674  1.000 51.36000  ? 164 THR B C   1 
ATOM   2455 O O   . THR B 1 46  ? -1.52041  -2.18746  -4.96773  1.000 58.30000  ? 164 THR B O   1 
ATOM   2456 C CB  . THR B 1 46  ? 0.14545   -3.69824  -2.91226  1.000 46.34000  ? 164 THR B CB  1 
ATOM   2457 O OG1 . THR B 1 46  ? -0.81422  -4.37810  -2.09175  1.000 49.04000  ? 164 THR B OG1 1 
ATOM   2458 C CG2 . THR B 1 46  ? 1.52870   -3.84120  -2.31684  1.000 41.71000  ? 164 THR B CG2 1 
ATOM   2459 N N   . THR B 1 47  ? -2.63956  -1.88917  -3.04328  1.000 50.09000  ? 165 THR B N   1 
ATOM   2460 C CA  . THR B 1 47  ? -3.88283  -1.52522  -3.70279  1.000 51.31000  ? 165 THR B CA  1 
ATOM   2461 C C   . THR B 1 47  ? -4.00791  -0.02626  -3.97093  1.000 54.00000  ? 165 THR B C   1 
ATOM   2462 O O   . THR B 1 47  ? -4.95219  0.37468   -4.65957  1.000 63.15000  ? 165 THR B O   1 
ATOM   2463 C CB  . THR B 1 47  ? -5.06448  -1.99608  -2.85921  1.000 53.91000  ? 165 THR B CB  1 
ATOM   2464 O OG1 . THR B 1 47  ? -5.19495  -1.15992  -1.69826  1.000 51.75000  ? 165 THR B OG1 1 
ATOM   2465 C CG2 . THR B 1 47  ? -4.84034  -3.43203  -2.43511  1.000 46.70000  ? 165 THR B CG2 1 
ATOM   2466 N N   . PHE B 1 48  ? -3.08865  0.80279   -3.45445  1.000 51.33000  ? 166 PHE B N   1 
ATOM   2467 C CA  . PHE B 1 48  ? -3.12770  2.25576   -3.65762  1.000 48.08000  ? 166 PHE B CA  1 
ATOM   2468 C C   . PHE B 1 48  ? -4.47149  2.84086   -3.22011  1.000 52.89000  ? 166 PHE B C   1 
ATOM   2469 O O   . PHE B 1 48  ? -4.99873  3.77079   -3.83501  1.000 55.69000  ? 166 PHE B O   1 
ATOM   2470 C CB  . PHE B 1 48  ? -2.82332  2.62456   -5.10880  1.000 37.73000  ? 166 PHE B CB  1 
ATOM   2471 C CG  . PHE B 1 48  ? -1.43052  2.28146   -5.54237  1.000 47.89000  ? 166 PHE B CG  1 
ATOM   2472 C CD1 . PHE B 1 48  ? -1.07468  0.95941   -5.81735  1.000 44.15000  ? 166 PHE B CD1 1 
ATOM   2473 C CD2 . PHE B 1 48  ? -0.46555  3.28141   -5.68592  1.000 47.58000  ? 166 PHE B CD2 1 
ATOM   2474 C CE1 . PHE B 1 48  ? 0.21513   0.63532   -6.21887  1.000 39.53000  ? 166 PHE B CE1 1 
ATOM   2475 C CE2 . PHE B 1 48  ? 0.82226   2.97031   -6.09644  1.000 46.96000  ? 166 PHE B CE2 1 
ATOM   2476 C CZ  . PHE B 1 48  ? 1.16510   1.63927   -6.36341  1.000 46.80000  ? 166 PHE B CZ  1 
ATOM   2477 N N   . SER B 1 49  ? -5.03104  2.27502   -2.14279  1.000 58.40000  ? 167 SER B N   1 
ATOM   2478 C CA  . SER B 1 49  ? -6.27977  2.78313   -1.57132  1.000 54.45000  ? 167 SER B CA  1 
ATOM   2479 C C   . SER B 1 49  ? -6.15152  4.21919   -1.09156  1.000 51.09000  ? 167 SER B C   1 
ATOM   2480 O O   . SER B 1 49  ? -7.12252  4.97822   -1.14724  1.000 55.10000  ? 167 SER B O   1 
ATOM   2481 C CB  . SER B 1 49  ? -6.71629  1.91230   -0.39501  1.000 56.10000  ? 167 SER B CB  1 
ATOM   2482 O OG  . SER B 1 49  ? -6.94550  0.57426   -0.79273  1.000 72.96000  ? 167 SER B OG  1 
ATOM   2483 N N   . HIS B 1 50  ? -4.98029  4.59923   -0.59213  1.000 51.07000  ? 168 HIS B N   1 
ATOM   2484 C CA  . HIS B 1 50  ? -4.78397  5.88631   0.05362   1.000 50.29000  ? 168 HIS B CA  1 
ATOM   2485 C C   . HIS B 1 50  ? -4.04833  6.87716   -0.83584  1.000 54.58000  ? 168 HIS B C   1 
ATOM   2486 O O   . HIS B 1 50  ? -3.65409  7.95222   -0.35915  1.000 48.06000  ? 168 HIS B O   1 
ATOM   2487 C CB  . HIS B 1 50  ? -4.05140  5.68146   1.38032   1.000 52.88000  ? 168 HIS B CB  1 
ATOM   2488 C CG  . HIS B 1 50  ? -4.76602  4.75261   2.31476   1.000 63.86000  ? 168 HIS B CG  1 
ATOM   2489 N ND1 . HIS B 1 50  ? -5.63758  5.19576   3.28808   1.000 69.98000  ? 168 HIS B ND1 1 
ATOM   2490 C CD2 . HIS B 1 50  ? -4.79303  3.39862   2.37795   1.000 67.69000  ? 168 HIS B CD2 1 
ATOM   2491 C CE1 . HIS B 1 50  ? -6.13833  4.15687   3.93544   1.000 72.15000  ? 168 HIS B CE1 1 
ATOM   2492 N NE2 . HIS B 1 50  ? -5.64759  3.05378   3.39837   1.000 63.48000  ? 168 HIS B NE2 1 
ATOM   2493 N N   . PHE B 1 51  ? -3.86390  6.54599   -2.12087  1.000 51.12000  ? 169 PHE B N   1 
ATOM   2494 C CA  . PHE B 1 51  ? -3.39430  7.52084   -3.10321  1.000 51.39000  ? 169 PHE B CA  1 
ATOM   2495 C C   . PHE B 1 51  ? -4.60249  8.31781   -3.60479  1.000 53.98000  ? 169 PHE B C   1 
ATOM   2496 O O   . PHE B 1 51  ? -5.41185  7.82473   -4.40137  1.000 57.61000  ? 169 PHE B O   1 
ATOM   2497 C CB  . PHE B 1 51  ? -2.64481  6.83567   -4.23945  1.000 45.48000  ? 169 PHE B CB  1 
ATOM   2498 C CG  . PHE B 1 51  ? -2.09523  7.79651   -5.25481  1.000 42.11000  ? 169 PHE B CG  1 
ATOM   2499 C CD1 . PHE B 1 51  ? -1.47801  8.98055   -4.84724  1.000 40.71000  ? 169 PHE B CD1 1 
ATOM   2500 C CD2 . PHE B 1 51  ? -2.20783  7.53834   -6.60973  1.000 39.52000  ? 169 PHE B CD2 1 
ATOM   2501 C CE1 . PHE B 1 51  ? -0.97640  9.89141   -5.78458  1.000 36.23000  ? 169 PHE B CE1 1 
ATOM   2502 C CE2 . PHE B 1 51  ? -1.70221  8.44220   -7.55007  1.000 42.41000  ? 169 PHE B CE2 1 
ATOM   2503 C CZ  . PHE B 1 51  ? -1.07999  9.61723   -7.12750  1.000 35.77000  ? 169 PHE B CZ  1 
ATOM   2504 N N   . LYS B 1 52  ? -4.73524  9.55588   -3.11790  1.000 53.67000  ? 170 LYS B N   1 
ATOM   2505 C CA  . LYS B 1 52  ? -5.88334  10.40688  -3.40651  1.000 60.34000  ? 170 LYS B CA  1 
ATOM   2506 C C   . LYS B 1 52  ? -5.42239  11.84383  -3.62090  1.000 63.48000  ? 170 LYS B C   1 
ATOM   2507 O O   . LYS B 1 52  ? -4.26228  12.19783  -3.37846  1.000 68.36000  ? 170 LYS B O   1 
ATOM   2508 C CB  . LYS B 1 52  ? -6.92585  10.35306  -2.27505  1.000 67.68000  ? 170 LYS B CB  1 
ATOM   2509 C CG  . LYS B 1 52  ? -7.52077  8.96212   -1.99360  1.000 62.63000  ? 170 LYS B CG  1 
ATOM   2510 C CD  . LYS B 1 52  ? -7.81212  8.78132   -0.49945  1.000 59.56000  ? 170 LYS B CD  1 
ATOM   2511 N N   . ASN B 1 53  ? -6.35957  12.67680  -4.07660  1.000 65.70000  ? 171 ASN B N   1 
ATOM   2512 C CA  . ASN B 1 53  ? -6.13060  14.11977  -4.25790  1.000 72.92000  ? 171 ASN B CA  1 
ATOM   2513 C C   . ASN B 1 53  ? -4.90497  14.39862  -5.11547  1.000 67.74000  ? 171 ASN B C   1 
ATOM   2514 O O   . ASN B 1 53  ? -4.13382  15.32263  -4.84393  1.000 76.53000  ? 171 ASN B O   1 
ATOM   2515 C CB  . ASN B 1 53  ? -6.00999  14.85495  -2.91905  1.000 69.15000  ? 171 ASN B CB  1 
ATOM   2516 C CG  . ASN B 1 53  ? -7.23762  14.68910  -2.04749  1.000 77.76000  ? 171 ASN B CG  1 
ATOM   2517 O OD1 . ASN B 1 53  ? -8.35784  14.57607  -2.54898  1.000 82.24000  ? 171 ASN B OD1 1 
ATOM   2518 N ND2 . ASN B 1 53  ? -7.03205  14.66627  -0.73458  1.000 79.80000  ? 171 ASN B ND2 1 
ATOM   2519 N N   . PHE B 1 54  ? -4.73545  13.60947  -6.17144  1.000 57.38000  ? 172 PHE B N   1 
ATOM   2520 C CA  . PHE B 1 54  ? -3.65986  13.84331  -7.11894  1.000 51.69000  ? 172 PHE B CA  1 
ATOM   2521 C C   . PHE B 1 54  ? -4.12534  14.71317  -8.28785  1.000 57.86000  ? 172 PHE B C   1 
ATOM   2522 O O   . PHE B 1 54  ? -5.32346  14.85117  -8.57435  1.000 55.52000  ? 172 PHE B O   1 
ATOM   2523 C CB  . PHE B 1 54  ? -3.09513  12.52023  -7.64201  1.000 50.31000  ? 172 PHE B CB  1 
ATOM   2524 C CG  . PHE B 1 54  ? -4.13832  11.50321  -8.00742  1.000 45.01000  ? 172 PHE B CG  1 
ATOM   2525 C CD1 . PHE B 1 54  ? -4.63688  11.44005  -9.29519  1.000 40.11000  ? 172 PHE B CD1 1 
ATOM   2526 C CD2 . PHE B 1 54  ? -4.59693  10.58435  -7.06809  1.000 45.73000  ? 172 PHE B CD2 1 
ATOM   2527 C CE1 . PHE B 1 54  ? -5.57506  10.50503  -9.63966  1.000 39.27000  ? 172 PHE B CE1 1 
ATOM   2528 C CE2 . PHE B 1 54  ? -5.55011  9.63833   -7.40955  1.000 45.40000  ? 172 PHE B CE2 1 
ATOM   2529 C CZ  . PHE B 1 54  ? -6.04468  9.60617   -8.70233  1.000 39.92000  ? 172 PHE B CZ  1 
ATOM   2530 N N   . ARG B 1 55  ? -3.14261  15.32305  -8.94536  1.000 60.44000  ? 173 ARG B N   1 
ATOM   2531 C CA  . ARG B 1 55  ? -3.36512  16.07890  -10.16637 1.000 50.90000  ? 173 ARG B CA  1 
ATOM   2532 C C   . ARG B 1 55  ? -3.57666  15.12775  -11.34115 1.000 53.79000  ? 173 ARG B C   1 
ATOM   2533 O O   . ARG B 1 55  ? -3.07270  13.99973  -11.35722 1.000 58.76000  ? 173 ARG B O   1 
ATOM   2534 C CB  . ARG B 1 55  ? -2.16921  16.98982  -10.43701 1.000 48.72000  ? 173 ARG B CB  1 
ATOM   2535 C CG  . ARG B 1 55  ? -2.04777  18.18195  -9.50522  1.000 47.74000  ? 173 ARG B CG  1 
ATOM   2536 C CD  . ARG B 1 55  ? -0.70784  18.88588  -9.71890  1.000 49.52000  ? 173 ARG B CD  1 
ATOM   2537 N NE  . ARG B 1 55  ? 0.27857   18.41097  -8.75627  1.000 55.16000  ? 173 ARG B NE  1 
ATOM   2538 C CZ  . ARG B 1 55  ? 1.59054   18.62193  -8.83087  1.000 62.27000  ? 173 ARG B CZ  1 
ATOM   2539 N NH1 . ARG B 1 55  ? 2.12312   19.30177  -9.83819  1.000 64.56000  ? 173 ARG B NH1 1 
ATOM   2540 N NH2 . ARG B 1 55  ? 2.38494   18.13203  -7.88615  1.000 69.93000  ? 173 ARG B NH2 1 
ATOM   2541 N N   . LEU B 1 56  ? -4.33008  15.58964  -12.33088 1.000 56.12000  ? 174 LEU B N   1 
ATOM   2542 C CA  . LEU B 1 56  ? -4.60564  14.84848  -13.55066 1.000 47.55000  ? 174 LEU B CA  1 
ATOM   2543 C C   . LEU B 1 56  ? -4.44611  15.80932  -14.71586 1.000 51.00000  ? 174 LEU B C   1 
ATOM   2544 O O   . LEU B 1 56  ? -4.47799  17.03035  -14.52501 1.000 56.89000  ? 174 LEU B O   1 
ATOM   2545 C CB  . LEU B 1 56  ? -6.01663  14.24353  -13.50496 1.000 51.57000  ? 174 LEU B CB  1 
ATOM   2546 C CG  . LEU B 1 56  ? -6.14531  12.95365  -12.67074 1.000 55.36000  ? 174 LEU B CG  1 
ATOM   2547 C CD1 . LEU B 1 56  ? -7.57429  12.41970  -12.59104 1.000 39.37000  ? 174 LEU B CD1 1 
ATOM   2548 C CD2 . LEU B 1 56  ? -5.19756  11.86255  -13.17800 1.000 49.54000  ? 174 LEU B CD2 1 
ATOM   2549 N N   . PRO B 1 57  ? -4.23366  15.30515  -15.92888 1.000 54.83000  ? 175 PRO B N   1 
ATOM   2550 C CA  . PRO B 1 57  ? -4.04613  16.21799  -17.07309 1.000 54.28000  ? 175 PRO B CA  1 
ATOM   2551 C C   . PRO B 1 57  ? -5.35527  16.90899  -17.43161 1.000 62.67000  ? 175 PRO B C   1 
ATOM   2552 O O   . PRO B 1 57  ? -6.38137  16.25099  -17.62607 1.000 65.32000  ? 175 PRO B O   1 
ATOM   2553 C CB  . PRO B 1 57  ? -3.56665  15.29683  -18.20117 1.000 50.16000  ? 175 PRO B CB  1 
ATOM   2554 C CG  . PRO B 1 57  ? -3.16439  14.00591  -17.51718 1.000 55.40000  ? 175 PRO B CG  1 
ATOM   2555 C CD  . PRO B 1 57  ? -4.05487  13.89510  -16.31177 1.000 47.50000  ? 175 PRO B CD  1 
ATOM   2556 N N   . GLY B 1 58  ? -5.31126  18.24097  -17.51481 1.000 61.56000  ? 176 GLY B N   1 
ATOM   2557 C CA  . GLY B 1 58  ? -6.49635  19.04998  -17.76840 1.000 67.58000  ? 176 GLY B CA  1 
ATOM   2558 C C   . GLY B 1 58  ? -7.44284  18.58886  -18.87092 1.000 65.18000  ? 176 GLY B C   1 
ATOM   2559 O O   . GLY B 1 58  ? -7.04727  17.88772  -19.80500 1.000 68.19000  ? 176 GLY B O   1 
ATOM   2560 N N   . GLU B 1 77  ? 19.99913  26.75033  -24.08299 1.000 91.13000  ? 195 GLU B N   1 
ATOM   2561 C CA  . GLU B 1 77  ? 18.76925  27.50240  -23.86456 1.000 91.70000  ? 195 GLU B CA  1 
ATOM   2562 C C   . GLU B 1 77  ? 17.66083  26.98331  -24.78000 1.000 95.86000  ? 195 GLU B C   1 
ATOM   2563 O O   . GLU B 1 77  ? 16.47095  27.20838  -24.53151 1.000 87.09000  ? 195 GLU B O   1 
ATOM   2564 C CB  . GLU B 1 77  ? 19.00619  28.99536  -24.09886 1.000 87.89000  ? 195 GLU B CB  1 
ATOM   2565 N N   . ALA B 1 78  ? 18.07735  26.29015  -25.84509 1.000 95.53000  ? 196 ALA B N   1 
ATOM   2566 C CA  . ALA B 1 78  ? 17.15592  25.66005  -26.78661 1.000 93.66000  ? 196 ALA B CA  1 
ATOM   2567 C C   . ALA B 1 78  ? 17.61066  24.29297  -27.27862 1.000 97.28000  ? 196 ALA B C   1 
ATOM   2568 O O   . ALA B 1 78  ? 16.77042  23.53693  -27.77915 1.000 97.32000  ? 196 ALA B O   1 
ATOM   2569 C CB  . ALA B 1 78  ? 16.91342  26.56890  -27.99862 1.000 89.78000  ? 196 ALA B CB  1 
ATOM   2570 N N   . ALA B 1 79  ? 18.89869  23.94295  -27.18714 1.000 98.98000  ? 197 ALA B N   1 
ATOM   2571 C CA  . ALA B 1 79  ? 19.27161  22.53592  -27.27711 1.000 92.96000  ? 197 ALA B CA  1 
ATOM   2572 C C   . ALA B 1 79  ? 18.94115  21.80411  -25.98787 1.000 94.30000  ? 197 ALA B C   1 
ATOM   2573 O O   . ALA B 1 79  ? 18.91412  20.56811  -25.97469 1.000 92.60000  ? 197 ALA B O   1 
ATOM   2574 C CB  . ALA B 1 79  ? 20.75746  22.38184  -27.60074 1.000 92.74000  ? 197 ALA B CB  1 
ATOM   2575 N N   . LYS B 1 80  ? 18.70264  22.55226  -24.90487 1.000 92.51000  ? 198 LYS B N   1 
ATOM   2576 C CA  . LYS B 1 80  ? 18.10415  21.97844  -23.70353 1.000 91.46000  ? 198 LYS B CA  1 
ATOM   2577 C C   . LYS B 1 80  ? 16.75699  21.33944  -24.02286 1.000 91.77000  ? 198 LYS B C   1 
ATOM   2578 O O   . LYS B 1 80  ? 16.46115  20.22550  -23.57358 1.000 86.77000  ? 198 LYS B O   1 
ATOM   2579 C CB  . LYS B 1 80  ? 17.95365  23.05959  -22.62861 1.000 77.07000  ? 198 LYS B CB  1 
ATOM   2580 N N   . TRP B 1 81  ? 15.92767  22.03335  -24.81159 1.000 91.94000  ? 199 TRP B N   1 
ATOM   2581 C CA  . TRP B 1 81  ? 14.64447  21.47834  -25.23195 1.000 84.12000  ? 199 TRP B CA  1 
ATOM   2582 C C   . TRP B 1 81  ? 14.82405  20.23922  -26.09486 1.000 83.56000  ? 199 TRP B C   1 
ATOM   2583 O O   . TRP B 1 81  ? 13.99705  19.32325  -26.04838 1.000 81.85000  ? 199 TRP B O   1 
ATOM   2584 C CB  . TRP B 1 81  ? 13.83717  22.53526  -25.98574 1.000 80.66000  ? 199 TRP B CB  1 
ATOM   2585 C CG  . TRP B 1 81  ? 13.01559  23.38341  -25.08149 1.000 81.47000  ? 199 TRP B CG  1 
ATOM   2586 C CD1 . TRP B 1 81  ? 13.43193  24.48049  -24.37382 1.000 85.18000  ? 199 TRP B CD1 1 
ATOM   2587 C CD2 . TRP B 1 81  ? 11.63372  23.20449  -24.76887 1.000 79.81000  ? 199 TRP B CD2 1 
ATOM   2588 N NE1 . TRP B 1 81  ? 12.38727  24.99562  -23.64044 1.000 71.92000  ? 199 TRP B NE1 1 
ATOM   2589 C CE2 . TRP B 1 81  ? 11.27215  24.23062  -23.86585 1.000 72.85000  ? 199 TRP B CE2 1 
ATOM   2590 C CE3 . TRP B 1 81  ? 10.66152  22.27347  -25.16132 1.000 82.04000  ? 199 TRP B CE3 1 
ATOM   2591 C CZ2 . TRP B 1 81  ? 9.98038   24.35273  -23.35130 1.000 74.02000  ? 199 TRP B CZ2 1 
ATOM   2592 C CZ3 . TRP B 1 81  ? 9.37475   22.39858  -24.64877 1.000 79.98000  ? 199 TRP B CZ3 1 
ATOM   2593 C CH2 . TRP B 1 81  ? 9.04717   23.43170  -23.75477 1.000 76.74000  ? 199 TRP B CH2 1 
ATOM   2594 N N   . SER B 1 82  ? 15.88570  20.18808  -26.89332 1.000 91.77000  ? 200 SER B N   1 
ATOM   2595 C CA  . SER B 1 82  ? 16.12133  18.98197  -27.66826 1.000 91.03000  ? 200 SER B CA  1 
ATOM   2596 C C   . SER B 1 82  ? 16.50969  17.81408  -26.76528 1.000 88.95000  ? 200 SER B C   1 
ATOM   2597 O O   . SER B 1 82  ? 16.16452  16.66605  -27.06697 1.000 85.51000  ? 200 SER B O   1 
ATOM   2598 C CB  . SER B 1 82  ? 17.18987  19.23679  -28.73076 1.000 85.82000  ? 200 SER B CB  1 
ATOM   2599 O OG  . SER B 1 82  ? 17.74364  18.01471  -29.19084 1.000 88.98000  ? 200 SER B OG  1 
ATOM   2600 N N   . GLN B 1 83  ? 17.19618  18.08320  -25.64561 1.000 87.18000  ? 201 GLN B N   1 
ATOM   2601 C CA  . GLN B 1 83  ? 17.61554  17.00031  -24.75465 1.000 86.37000  ? 201 GLN B CA  1 
ATOM   2602 C C   . GLN B 1 83  ? 16.46992  16.54047  -23.85409 1.000 80.05000  ? 201 GLN B C   1 
ATOM   2603 O O   . GLN B 1 83  ? 16.23795  15.33649  -23.71283 1.000 80.64000  ? 201 GLN B O   1 
ATOM   2604 C CB  . GLN B 1 83  ? 18.83192  17.42639  -23.92024 1.000 83.06000  ? 201 GLN B CB  1 
ATOM   2605 C CG  . GLN B 1 83  ? 19.39628  16.33149  -23.00534 1.000 74.85000  ? 201 GLN B CG  1 
ATOM   2606 C CD  . GLN B 1 83  ? 19.92192  15.12637  -23.76641 1.000 78.21000  ? 201 GLN B CD  1 
ATOM   2607 N N   . VAL B 1 84  ? 15.74622  17.48057  -23.23490 1.000 81.81000  ? 202 VAL B N   1 
ATOM   2608 C CA  . VAL B 1 84  ? 14.55455  17.12771  -22.46133 1.000 75.09000  ? 202 VAL B CA  1 
ATOM   2609 C C   . VAL B 1 84  ? 13.57216  16.31763  -23.29579 1.000 82.92000  ? 202 VAL B C   1 
ATOM   2610 O O   . VAL B 1 84  ? 12.96334  15.35971  -22.80040 1.000 81.60000  ? 202 VAL B O   1 
ATOM   2611 C CB  . VAL B 1 84  ? 13.88184  18.38281  -21.88620 1.000 64.69000  ? 202 VAL B CB  1 
ATOM   2612 C CG1 . VAL B 1 84  ? 12.55909  18.00793  -21.27458 1.000 64.11000  ? 202 VAL B CG1 1 
ATOM   2613 C CG2 . VAL B 1 84  ? 14.76032  19.00992  -20.81867 1.000 70.97000  ? 202 VAL B CG2 1 
ATOM   2614 N N   . ARG B 1 85  ? 13.38561  16.68447  -24.56376 1.000 84.49000  ? 203 ARG B N   1 
ATOM   2615 C CA  . ARG B 1 85  ? 12.48023  15.89938  -25.39326 1.000 83.48000  ? 203 ARG B CA  1 
ATOM   2616 C C   . ARG B 1 85  ? 13.00012  14.47335  -25.54730 1.000 75.27000  ? 203 ARG B C   1 
ATOM   2617 O O   . ARG B 1 85  ? 12.22211  13.51438  -25.49683 1.000 75.30000  ? 203 ARG B O   1 
ATOM   2618 C CB  . ARG B 1 85  ? 12.27065  16.57621  -26.75426 1.000 79.43000  ? 203 ARG B CB  1 
ATOM   2619 N N   . LYS B 1 86  ? 14.32305  14.31429  -25.68785 1.000 79.09000  ? 204 LYS B N   1 
ATOM   2620 C CA  . LYS B 1 86  ? 14.91496  12.98325  -25.80793 1.000 81.65000  ? 204 LYS B CA  1 
ATOM   2621 C C   . LYS B 1 86  ? 14.76650  12.18243  -24.51976 1.000 79.23000  ? 204 LYS B C   1 
ATOM   2622 O O   . LYS B 1 86  ? 14.65944  10.95043  -24.56755 1.000 76.40000  ? 204 LYS B O   1 
ATOM   2623 C CB  . LYS B 1 86  ? 16.39479  13.08616  -26.19859 1.000 73.30000  ? 204 LYS B CB  1 
ATOM   2624 N N   . ASP B 1 87  ? 14.75502  12.86058  -23.36785 1.000 74.63000  ? 205 ASP B N   1 
ATOM   2625 C CA  . ASP B 1 87  ? 14.52656  12.18576  -22.09166 1.000 74.32000  ? 205 ASP B CA  1 
ATOM   2626 C C   . ASP B 1 87  ? 13.14956  11.52081  -22.04697 1.000 78.15000  ? 205 ASP B C   1 
ATOM   2627 O O   . ASP B 1 87  ? 13.03263  10.31385  -21.79376 1.000 81.72000  ? 205 ASP B O   1 
ATOM   2628 C CB  . ASP B 1 87  ? 14.68409  13.18391  -20.93986 1.000 63.56000  ? 205 ASP B CB  1 
ATOM   2629 C CG  . ASP B 1 87  ? 16.11516  13.74088  -20.82556 1.000 74.18000  ? 205 ASP B CG  1 
ATOM   2630 O OD1 . ASP B 1 87  ? 17.09798  13.03080  -21.18489 1.000 70.73000  ? 205 ASP B OD1 1 
ATOM   2631 O OD2 . ASP B 1 87  ? 16.25540  14.89094  -20.34277 1.000 68.15000  ? 205 ASP B OD2 1 
ATOM   2632 N N   . LEU B 1 88  ? 12.09746  12.28680  -22.32261 1.000 76.90000  ? 206 LEU B N   1 
ATOM   2633 C CA  . LEU B 1 88  ? 10.73954  11.81087  -22.10595 1.000 68.50000  ? 206 LEU B CA  1 
ATOM   2634 C C   . LEU B 1 88  ? 10.20503  10.90074  -23.20960 1.000 72.69000  ? 206 LEU B C   1 
ATOM   2635 O O   . LEU B 1 88  ? 9.22111   10.19780  -22.96508 1.000 71.42000  ? 206 LEU B O   1 
ATOM   2636 C CB  . LEU B 1 88  ? 9.80265   13.00592  -21.94171 1.000 62.82000  ? 206 LEU B CB  1 
ATOM   2637 C CG  . LEU B 1 88  ? 10.19318  13.90607  -20.77200 1.000 70.91000  ? 206 LEU B CG  1 
ATOM   2638 C CD1 . LEU B 1 88  ? 9.32024   15.15610  -20.72678 1.000 64.54000  ? 206 LEU B CD1 1 
ATOM   2639 C CD2 . LEU B 1 88  ? 10.13174  13.12725  -19.45687 1.000 67.14000  ? 206 LEU B CD2 1 
ATOM   2640 N N   . CYS B 1 89  ? 10.80250  10.88456  -24.40986 1.000 74.35000  ? 207 CYS B N   1 
ATOM   2641 C CA  . CYS B 1 89  ? 10.05600  10.32844  -25.53846 1.000 74.50000  ? 207 CYS B CA  1 
ATOM   2642 C C   . CYS B 1 89  ? 9.99698   8.80745   -25.47823 1.000 70.90000  ? 207 CYS B C   1 
ATOM   2643 O O   . CYS B 1 89  ? 9.08571   8.19940   -26.05375 1.000 74.70000  ? 207 CYS B O   1 
ATOM   2644 C CB  . CYS B 1 89  ? 10.63542  10.77224  -26.89477 1.000 68.61000  ? 207 CYS B CB  1 
ATOM   2645 S SG  . CYS B 1 89  ? 12.22717  10.05912  -27.41837 1.000 89.18000  ? 207 CYS B SG  1 
ATOM   2646 N N   . SER B 1 90  ? 10.94825  8.17351   -24.80356 1.000 71.63000  ? 208 SER B N   1 
ATOM   2647 C CA  . SER B 1 90  ? 10.91925  6.72352   -24.69335 1.000 76.69000  ? 208 SER B CA  1 
ATOM   2648 C C   . SER B 1 90  ? 10.23780  6.25171   -23.40799 1.000 73.83000  ? 208 SER B C   1 
ATOM   2649 O O   . SER B 1 90  ? 10.17987  5.04375   -23.16481 1.000 74.06000  ? 208 SER B O   1 
ATOM   2650 C CB  . SER B 1 90  ? 12.34319  6.16047   -24.79990 1.000 76.48000  ? 208 SER B CB  1 
ATOM   2651 O OG  . SER B 1 90  ? 12.92265  6.46728   -26.06819 1.000 79.40000  ? 208 SER B OG  1 
ATOM   2652 N N   . LEU B 1 91  ? 9.70118   7.17984   -22.60288 1.000 67.29000  ? 209 LEU B N   1 
ATOM   2653 C CA  . LEU B 1 91  ? 9.02172   6.90003   -21.34155 1.000 59.32000  ? 209 LEU B CA  1 
ATOM   2654 C C   . LEU B 1 91  ? 7.53372   7.26107   -21.38495 1.000 65.37000  ? 209 LEU B C   1 
ATOM   2655 O O   . LEU B 1 91  ? 6.92218   7.52123   -20.34071 1.000 53.61000  ? 209 LEU B O   1 
ATOM   2656 C CB  . LEU B 1 91  ? 9.69025   7.65816   -20.19294 1.000 61.78000  ? 209 LEU B CB  1 
ATOM   2657 C CG  . LEU B 1 91  ? 11.18734  7.47214   -19.97757 1.000 64.69000  ? 209 LEU B CG  1 
ATOM   2658 C CD1 . LEU B 1 91  ? 11.72684  8.40527   -18.88393 1.000 55.73000  ? 209 LEU B CD1 1 
ATOM   2659 C CD2 . LEU B 1 91  ? 11.44543  6.00818   -19.65049 1.000 61.06000  ? 209 LEU B CD2 1 
ATOM   2660 N N   . LYS B 1 92  ? 6.94319   7.29693   -22.58269 1.000 68.54000  ? 210 LYS B N   1 
ATOM   2661 C CA  . LYS B 1 92  ? 5.55813   7.71794   -22.75415 1.000 58.78000  ? 210 LYS B CA  1 
ATOM   2662 C C   . LYS B 1 92  ? 4.60831   6.62404   -22.27359 1.000 58.83000  ? 210 LYS B C   1 
ATOM   2663 O O   . LYS B 1 92  ? 4.74511   5.45498   -22.65449 1.000 54.73000  ? 210 LYS B O   1 
ATOM   2664 C CB  . LYS B 1 92  ? 5.28950   8.05876   -24.22407 1.000 56.82000  ? 210 LYS B CB  1 
ATOM   2665 N N   . VAL B 1 93  ? 3.63968   7.00118   -21.43721 1.000 56.80000  ? 211 VAL B N   1 
ATOM   2666 C CA  . VAL B 1 93  ? 2.61986   6.06427   -20.97464 1.000 54.55000  ? 211 VAL B CA  1 
ATOM   2667 C C   . VAL B 1 93  ? 1.24585   6.72130   -21.03713 1.000 49.60000  ? 211 VAL B C   1 
ATOM   2668 O O   . VAL B 1 93  ? 1.11394   7.94032   -20.92124 1.000 51.76000  ? 211 VAL B O   1 
ATOM   2669 C CB  . VAL B 1 93  ? 2.89947   5.53945   -19.54169 1.000 50.72000  ? 211 VAL B CB  1 
ATOM   2670 C CG1 . VAL B 1 93  ? 4.20447   4.76142   -19.49016 1.000 55.49000  ? 211 VAL B CG1 1 
ATOM   2671 C CG2 . VAL B 1 93  ? 2.90794   6.68859   -18.54385 1.000 47.04000  ? 211 VAL B CG2 1 
ATOM   2672 N N   . SER B 1 94  ? 0.22175   5.89731   -21.21757 1.000 48.45000  ? 212 SER B N   1 
ATOM   2673 C CA  . SER B 1 94  ? -1.16115  6.29238   -21.00902 1.000 50.85000  ? 212 SER B CA  1 
ATOM   2674 C C   . SER B 1 94  ? -1.63055  5.90758   -19.59377 1.000 51.33000  ? 212 SER B C   1 
ATOM   2675 O O   . SER B 1 94  ? -0.97025  5.16466   -18.86395 1.000 48.24000  ? 212 SER B O   1 
ATOM   2676 C CB  . SER B 1 94  ? -2.04164  5.65827   -22.07955 1.000 37.30000  ? 212 SER B CB  1 
ATOM   2677 O OG  . SER B 1 94  ? -1.90866  4.25827   -22.03342 1.000 59.80000  ? 212 SER B OG  1 
ATOM   2678 N N   . LEU B 1 95  ? -2.79736  6.42567   -19.20833 1.000 50.65000  ? 213 LEU B N   1 
ATOM   2679 C CA  . LEU B 1 95  ? -3.28776  6.34787   -17.83710 1.000 44.10000  ? 213 LEU B CA  1 
ATOM   2680 C C   . LEU B 1 95  ? -4.70978  5.81491   -17.84041 1.000 51.03000  ? 213 LEU B C   1 
ATOM   2681 O O   . LEU B 1 95  ? -5.55809  6.30284   -18.58810 1.000 56.62000  ? 213 LEU B O   1 
ATOM   2682 C CB  . LEU B 1 95  ? -3.25743  7.72496   -17.17030 1.000 46.24000  ? 213 LEU B CB  1 
ATOM   2683 C CG  . LEU B 1 95  ? -3.34977  7.82916   -15.65227 1.000 46.00000  ? 213 LEU B CG  1 
ATOM   2684 C CD1 . LEU B 1 95  ? -2.85351  9.17621   -15.15567 1.000 51.62000  ? 213 LEU B CD1 1 
ATOM   2685 C CD2 . LEU B 1 95  ? -4.73659  7.65326   -15.22564 1.000 57.88000  ? 213 LEU B CD2 1 
ATOM   2686 N N   . GLN B 1 96  ? -4.98043  4.85104   -16.97516 1.000 58.14000  ? 214 GLN B N   1 
ATOM   2687 C CA  . GLN B 1 96  ? -6.35539  4.32710   -16.84049 1.000 50.62000  ? 214 GLN B CA  1 
ATOM   2688 C C   . GLN B 1 96  ? -6.76975  4.51030   -15.38633 1.000 52.75000  ? 214 GLN B C   1 
ATOM   2689 O O   . GLN B 1 96  ? -5.94438  4.31339   -14.52667 1.000 54.22000  ? 214 GLN B O   1 
ATOM   2690 C CB  . GLN B 1 96  ? -6.43862  2.86704   -17.26826 1.000 51.78000  ? 214 GLN B CB  1 
ATOM   2691 C CG  . GLN B 1 96  ? -7.85562  2.32709   -17.22757 1.000 54.92000  ? 214 GLN B CG  1 
ATOM   2692 C CD  . GLN B 1 96  ? -7.96489  0.92202   -17.74433 1.000 51.89000  ? 214 GLN B CD  1 
ATOM   2693 O OE1 . GLN B 1 96  ? -8.21259  -0.01087  -17.00110 1.000 56.46000  ? 214 GLN B OE1 1 
ATOM   2694 N NE2 . GLN B 1 96  ? -7.79446  0.76385   -19.03639 1.000 53.53000  ? 214 GLN B NE2 1 
ATOM   2695 N N   . LEU B 1 97  ? -8.00564  4.93037   -15.15185 1.000 56.08000  ? 215 LEU B N   1 
ATOM   2696 C CA  . LEU B 1 97  ? -8.50803  5.12857   -13.77766 1.000 52.46000  ? 215 LEU B CA  1 
ATOM   2697 C C   . LEU B 1 97  ? -9.81400  4.36863   -13.65399 1.000 54.10000  ? 215 LEU B C   1 
ATOM   2698 O O   . LEU B 1 97  ? -10.76725 4.78957   -14.26363 1.000 60.86000  ? 215 LEU B O   1 
ATOM   2699 C CB  . LEU B 1 97  ? -8.77889  6.61161   -13.57074 1.000 51.23000  ? 215 LEU B CB  1 
ATOM   2700 C CG  . LEU B 1 97  ? -7.53980  7.47559   -13.41339 1.000 59.92000  ? 215 LEU B CG  1 
ATOM   2701 C CD1 . LEU B 1 97  ? -7.86288  8.92456   -13.69545 1.000 55.81000  ? 215 LEU B CD1 1 
ATOM   2702 C CD2 . LEU B 1 97  ? -6.98020  7.32376   -12.01762 1.000 70.08000  ? 215 LEU B CD2 1 
ATOM   2703 N N   . ARG B 1 98  ? -9.83270  3.28573   -12.89283 1.000 52.76000  ? 216 ARG B N   1 
ATOM   2704 C CA  . ARG B 1 98  ? -11.09265 2.53679   -12.72218 1.000 57.29000  ? 216 ARG B CA  1 
ATOM   2705 C C   . ARG B 1 98  ? -11.81310 3.11597   -11.51195 1.000 61.90000  ? 216 ARG B C   1 
ATOM   2706 O O   . ARG B 1 98  ? -11.15566 3.38909   -10.52427 1.000 62.62000  ? 216 ARG B O   1 
ATOM   2707 C CB  . ARG B 1 98  ? -10.82161 1.04481   -12.53910 1.000 59.68000  ? 216 ARG B CB  1 
ATOM   2708 C CG  . ARG B 1 98  ? -10.26217 0.36462   -13.77426 1.000 56.40000  ? 216 ARG B CG  1 
ATOM   2709 C CD  . ARG B 1 98  ? -9.94012  -1.09036  -13.54820 1.000 53.94000  ? 216 ARG B CD  1 
ATOM   2710 N NE  . ARG B 1 98  ? -8.60490  -1.35533  -13.03875 1.000 68.70000  ? 216 ARG B NE  1 
ATOM   2711 C CZ  . ARG B 1 98  ? -7.48806  -0.75241  -13.42632 1.000 71.90000  ? 216 ARG B CZ  1 
ATOM   2712 N NH1 . ARG B 1 98  ? -7.51443  0.18846   -14.34843 1.000 60.71000  ? 216 ARG B NH1 1 
ATOM   2713 N NH2 . ARG B 1 98  ? -6.33883  -1.09638  -12.88477 1.000 68.37000  ? 216 ARG B NH2 1 
ATOM   2714 N N   . GLY B 1 99  ? -13.11115 3.35600   -11.63541 1.000 58.28000  ? 217 GLY B N   1 
ATOM   2715 C CA  . GLY B 1 99  ? -13.89165 3.85717   -10.52914 1.000 53.79000  ? 217 GLY B CA  1 
ATOM   2716 C C   . GLY B 1 99  ? -14.43332 2.72230   -9.68275  1.000 61.61000  ? 217 GLY B C   1 
ATOM   2717 O O   . GLY B 1 99  ? -14.68456 1.61624   -10.16949 1.000 60.16000  ? 217 GLY B O   1 
ATOM   2718 N N   . GLU B 1 100 ? -14.61074 3.01248   -8.39171  1.000 63.77000  ? 218 GLU B N   1 
ATOM   2719 C CA  . GLU B 1 100 ? -15.17538 2.01961   -7.48433  1.000 70.72000  ? 218 GLU B CA  1 
ATOM   2720 C C   . GLU B 1 100 ? -16.51461 1.47959   -7.98067  1.000 71.22000  ? 218 GLU B C   1 
ATOM   2721 O O   . GLU B 1 100 ? -16.90447 0.37765   -7.58036  1.000 75.84000  ? 218 GLU B O   1 
ATOM   2722 C CB  . GLU B 1 100 ? -15.32875 2.62081   -6.08434  1.000 66.80000  ? 218 GLU B CB  1 
ATOM   2723 N N   . ASP B 1 101 ? -17.20098 2.20949   -8.87047  1.000 67.79000  ? 219 ASP B N   1 
ATOM   2724 C CA  . ASP B 1 101 ? -18.51321 1.83046   -9.38285  1.000 65.73000  ? 219 ASP B CA  1 
ATOM   2725 C C   . ASP B 1 101 ? -18.46379 0.96329   -10.64076 1.000 63.62000  ? 219 ASP B C   1 
ATOM   2726 O O   . ASP B 1 101 ? -19.51700 0.50126   -11.09423 1.000 62.86000  ? 219 ASP B O   1 
ATOM   2727 C CB  . ASP B 1 101 ? -19.34631 3.08445   -9.68365  1.000 66.69000  ? 219 ASP B CB  1 
ATOM   2728 C CG  . ASP B 1 101 ? -18.66971 4.02329   -10.68107 1.000 72.67000  ? 219 ASP B CG  1 
ATOM   2729 O OD1 . ASP B 1 101 ? -17.57794 3.66819   -11.18750 1.000 68.70000  ? 219 ASP B OD1 1 
ATOM   2730 O OD2 . ASP B 1 101 ? -19.24781 5.10627   -10.97397 1.000 66.83000  ? 219 ASP B OD2 1 
ATOM   2731 N N   . GLY B 1 102 ? -17.28905 0.73418   -11.22324 1.000 62.94000  ? 220 GLY B N   1 
ATOM   2732 C CA  . GLY B 1 102 ? -17.18161 -0.00999  -12.46019 1.000 57.36000  ? 220 GLY B CA  1 
ATOM   2733 C C   . GLY B 1 102 ? -16.86912 0.82884   -13.68443 1.000 67.07000  ? 220 GLY B C   1 
ATOM   2734 O O   . GLY B 1 102 ? -16.48859 0.26169   -14.71952 1.000 67.01000  ? 220 GLY B O   1 
ATOM   2735 N N   . SER B 1 103 ? -17.01404 2.15585   -13.60155 1.000 63.96000  ? 221 SER B N   1 
ATOM   2736 C CA  . SER B 1 103 ? -16.64250 3.02369   -14.71083 1.000 59.27000  ? 221 SER B CA  1 
ATOM   2737 C C   . SER B 1 103 ? -15.13060 3.00862   -14.93748 1.000 57.83000  ? 221 SER B C   1 
ATOM   2738 O O   . SER B 1 103 ? -14.34524 2.60671   -14.07477 1.000 57.16000  ? 221 SER B O   1 
ATOM   2739 C CB  . SER B 1 103 ? -17.07834 4.45774   -14.44783 1.000 57.31000  ? 221 SER B CB  1 
ATOM   2740 O OG  . SER B 1 103 ? -16.34386 5.00786   -13.36722 1.000 57.58000  ? 221 SER B OG  1 
ATOM   2741 N N   . VAL B 1 104 ? -14.72210 3.48245   -16.11273 1.000 54.36000  ? 222 VAL B N   1 
ATOM   2742 C CA  . VAL B 1 104 ? -13.31126 3.54336   -16.48035 1.000 58.02000  ? 222 VAL B CA  1 
ATOM   2743 C C   . VAL B 1 104 ? -13.04153 4.87725   -17.18665 1.000 57.20000  ? 222 VAL B C   1 
ATOM   2744 O O   . VAL B 1 104 ? -13.72894 5.23414   -18.15339 1.000 53.42000  ? 222 VAL B O   1 
ATOM   2745 C CB  . VAL B 1 104 ? -12.90770 2.37822   -17.40337 1.000 52.03000  ? 222 VAL B CB  1 
ATOM   2746 C CG1 . VAL B 1 104 ? -11.43784 2.47513   -17.74603 1.000 48.60000  ? 222 VAL B CG1 1 
ATOM   2747 C CG2 . VAL B 1 104 ? -13.28448 1.04831   -16.81303 1.000 59.35000  ? 222 VAL B CG2 1 
ATOM   2748 N N   . TRP B 1 105 ? -12.01530 5.59028   -16.72519 1.000 52.92000  ? 223 TRP B N   1 
ATOM   2749 C CA  . TRP B 1 105 ? -11.59055 6.84518   -17.38454 1.000 54.52000  ? 223 TRP B CA  1 
ATOM   2750 C C   . TRP B 1 105 ? -10.21382 6.58006   -17.97511 1.000 55.92000  ? 223 TRP B C   1 
ATOM   2751 O O   . TRP B 1 105 ? -9.30450  6.23814   -17.21246 1.000 58.39000  ? 223 TRP B O   1 
ATOM   2752 C CB  . TRP B 1 105 ? -11.51307 7.98132   -16.36373 1.000 53.10000  ? 223 TRP B CB  1 
ATOM   2753 C CG  . TRP B 1 105 ? -12.66103 8.95536   -16.33136 1.000 53.14000  ? 223 TRP B CG  1 
ATOM   2754 C CD1 . TRP B 1 105 ? -13.51757 9.15452   -15.29101 1.000 55.66000  ? 223 TRP B CD1 1 
ATOM   2755 C CD2 . TRP B 1 105 ? -13.03744 9.90923   -17.34632 1.000 54.14000  ? 223 TRP B CD2 1 
ATOM   2756 N NE1 . TRP B 1 105 ? -14.41367 10.14351  -15.59175 1.000 57.53000  ? 223 TRP B NE1 1 
ATOM   2757 C CE2 . TRP B 1 105 ? -14.14220 10.62733  -16.84293 1.000 58.39000  ? 223 TRP B CE2 1 
ATOM   2758 C CE3 . TRP B 1 105 ? -12.55899 10.22005  -18.62157 1.000 49.26000  ? 223 TRP B CE3 1 
ATOM   2759 C CZ2 . TRP B 1 105 ? -14.77349 11.62925  -17.57279 1.000 51.19000  ? 223 TRP B CZ2 1 
ATOM   2760 C CZ3 . TRP B 1 105 ? -13.18327 11.21197  -19.34143 1.000 47.84000  ? 223 TRP B CZ3 1 
ATOM   2761 C CH2 . TRP B 1 105 ? -14.27103 11.90907  -18.82105 1.000 51.28000  ? 223 TRP B CH2 1 
ATOM   2762 N N   . ASN B 1 106 ? -10.06739 6.71288   -19.28919 1.000 55.57000  ? 224 ASN B N   1 
ATOM   2763 C CA  . ASN B 1 106 ? -8.77669  6.39575   -19.95171 1.000 55.05000  ? 224 ASN B CA  1 
ATOM   2764 C C   . ASN B 1 106 ? -8.17592  7.65965   -20.56314 1.000 52.39000  ? 224 ASN B C   1 
ATOM   2765 O O   . ASN B 1 106 ? -8.91018  8.40359   -21.21892 1.000 55.70000  ? 224 ASN B O   1 
ATOM   2766 C CB  . ASN B 1 106 ? -8.95318  5.30962   -20.99949 1.000 57.12000  ? 224 ASN B CB  1 
ATOM   2767 C CG  . ASN B 1 106 ? -8.01212  4.15162   -20.79075 1.000 70.82000  ? 224 ASN B CG  1 
ATOM   2768 O OD1 . ASN B 1 106 ? -6.82200  4.35362   -20.53429 1.000 69.70000  ? 224 ASN B OD1 1 
ATOM   2769 N ND2 . ASN B 1 106 ? -8.52421  2.93662   -20.91036 1.000 63.15000  ? 224 ASN B ND2 1 
ATOM   2770 N N   . TYR B 1 107 ? -6.87782  7.87564   -20.35074 1.000 45.25000  ? 225 TYR B N   1 
ATOM   2771 C CA  . TYR B 1 107 ? -6.20801  9.08655   -20.88519 1.000 48.97000  ? 225 TYR B CA  1 
ATOM   2772 C C   . TYR B 1 107 ? -5.05042  8.73540   -21.78665 1.000 50.60000  ? 225 TYR B C   1 
ATOM   2773 O O   . TYR B 1 107 ? -4.08523  8.12843   -21.31999 1.000 53.30000  ? 225 TYR B O   1 
ATOM   2774 C CB  . TYR B 1 107 ? -5.65751  10.00468  -19.79655 1.000 49.15000  ? 225 TYR B CB  1 
ATOM   2775 C CG  . TYR B 1 107 ? -4.82169  11.17359  -20.29708 1.000 52.91000  ? 225 TYR B CG  1 
ATOM   2776 C CD1 . TYR B 1 107 ? -5.42189  12.30454  -20.82697 1.000 49.76000  ? 225 TYR B CD1 1 
ATOM   2777 C CD2 . TYR B 1 107 ? -3.43466  11.14455  -20.23268 1.000 53.10000  ? 225 TYR B CD2 1 
ATOM   2778 C CE1 . TYR B 1 107 ? -4.66905  13.37345  -21.27644 1.000 49.17000  ? 225 TYR B CE1 1 
ATOM   2779 C CE2 . TYR B 1 107 ? -2.66983  12.20247  -20.69115 1.000 53.65000  ? 225 TYR B CE2 1 
ATOM   2780 C CZ  . TYR B 1 107 ? -3.29003  13.32042  -21.21403 1.000 58.07000  ? 225 TYR B CZ  1 
ATOM   2781 O OH  . TYR B 1 107 ? -2.54019  14.36734  -21.65850 1.000 53.24000  ? 225 TYR B OH  1 
ATOM   2782 N N   . LYS B 1 108 ? -5.16196  9.07423   -23.06365 1.000 50.32000  ? 226 LYS B N   1 
ATOM   2783 C CA  . LYS B 1 108 ? -4.05038  8.94707   -24.00112 1.000 47.84000  ? 226 LYS B CA  1 
ATOM   2784 C C   . LYS B 1 108 ? -3.36440  10.29903  -24.15060 1.000 56.33000  ? 226 LYS B C   1 
ATOM   2785 O O   . LYS B 1 108 ? -4.05244  11.31703  -24.31043 1.000 55.63000  ? 226 LYS B O   1 
ATOM   2786 C CB  . LYS B 1 108 ? -4.54299  8.45790   -25.35984 1.000 48.20000  ? 226 LYS B CB  1 
ATOM   2787 C CG  . LYS B 1 108 ? -3.45145  8.19073   -26.39728 1.000 52.90000  ? 226 LYS B CG  1 
ATOM   2788 N N   . PRO B 1 109 ? -2.03837  10.38300  -24.08419 1.000 58.85000  ? 227 PRO B N   1 
ATOM   2789 C CA  . PRO B 1 109 ? -1.37436  11.69097  -24.14265 1.000 58.63000  ? 227 PRO B CA  1 
ATOM   2790 C C   . PRO B 1 109 ? -1.23197  12.17377  -25.57578 1.000 58.20000  ? 227 PRO B C   1 
ATOM   2791 O O   . PRO B 1 109 ? -1.34740  11.37665  -26.51762 1.000 59.93000  ? 227 PRO B O   1 
ATOM   2792 C CB  . PRO B 1 109 ? -0.00409  11.41201  -23.50621 1.000 54.55000  ? 227 PRO B CB  1 
ATOM   2793 C CG  . PRO B 1 109 ? 0.25074   9.98396   -23.81613 1.000 51.57000  ? 227 PRO B CG  1 
ATOM   2794 C CD  . PRO B 1 109 ? -1.09326  9.30201   -23.75145 1.000 55.34000  ? 227 PRO B CD  1 
ATOM   2795 N N   . PRO B 1 110 ? -0.97602  13.46874  -25.78406 1.000 56.91000  ? 228 PRO B N   1 
ATOM   2796 C CA  . PRO B 1 110 ? -0.71759  13.95555  -27.14024 1.000 64.50000  ? 228 PRO B CA  1 
ATOM   2797 C C   . PRO B 1 110 ? 0.61215   13.45044  -27.68075 1.000 74.99000  ? 228 PRO B C   1 
ATOM   2798 O O   . PRO B 1 110 ? 1.54047   13.13451  -26.93012 1.000 72.08000  ? 228 PRO B O   1 
ATOM   2799 C CB  . PRO B 1 110 ? -0.69647  15.47757  -26.96645 1.000 64.07000  ? 228 PRO B CB  1 
ATOM   2800 C CG  . PRO B 1 110 ? -0.30485  15.67875  -25.55765 1.000 57.22000  ? 228 PRO B CG  1 
ATOM   2801 C CD  . PRO B 1 110 ? -0.92455  14.56487  -24.79723 1.000 54.82000  ? 228 PRO B CD  1 
ATOM   2802 N N   . ALA B 1 111 ? 0.69157   13.36726  -29.00878 1.000 79.84000  ? 229 ALA B N   1 
ATOM   2803 C CA  . ALA B 1 111 ? 1.97828   13.16013  -29.66031 1.000 83.87000  ? 229 ALA B CA  1 
ATOM   2804 C C   . ALA B 1 111 ? 2.85039   14.40313  -29.49386 1.000 84.17000  ? 229 ALA B C   1 
ATOM   2805 O O   . ALA B 1 111 ? 2.35249   15.52316  -29.34479 1.000 82.95000  ? 229 ALA B O   1 
ATOM   2806 C CB  . ALA B 1 111 ? 1.78562   12.83394  -31.14118 1.000 71.26000  ? 229 ALA B CB  1 
ATOM   2807 N N   . ASP B 1 112 ? 4.16135   14.21307  -29.58040 1.000 82.08000  ? 230 ASP B N   1 
ATOM   2808 C CA  . ASP B 1 112 ? 5.05845   15.38007  -29.41795 1.000 92.41000  ? 230 ASP B CA  1 
ATOM   2809 C C   . ASP B 1 112 ? 4.93795   16.28691  -30.63702 1.000 93.38000  ? 230 ASP B C   1 
ATOM   2810 O O   . ASP B 1 112 ? 5.40347   15.90475  -31.70517 1.000 93.00000  ? 230 ASP B O   1 
ATOM   2811 C CB  . ASP B 1 112 ? 6.51354   14.97305  -29.19553 1.000 96.88000  ? 230 ASP B CB  1 
ATOM   2812 C CG  . ASP B 1 112 ? 7.43766   16.15905  -28.99709 1.000 93.59000  ? 230 ASP B CG  1 
ATOM   2813 O OD1 . ASP B 1 112 ? 6.93576   17.27809  -28.84903 1.000 84.88000  ? 230 ASP B OD1 1 
ATOM   2814 O OD2 . ASP B 1 112 ? 8.64466   15.94602  -28.99459 1.000 90.02000  ? 230 ASP B OD2 1 
ATOM   2815 N N   . SER B 1 113 ? 4.30306   17.43995  -30.45890 1.000 91.91000  ? 231 SER B N   1 
ATOM   2816 C CA  . SER B 1 113 ? 4.19362   18.44881  -31.53998 1.000 96.93000  ? 231 SER B CA  1 
ATOM   2817 C C   . SER B 1 113 ? 5.22078   19.54782  -31.25458 1.000 101.62000 ? 231 SER B C   1 
ATOM   2818 O O   . SER B 1 113 ? 5.10655   20.62174  -31.85067 1.000 95.04000  ? 231 SER B O   1 
ATOM   2819 C CB  . SER B 1 113 ? 2.80461   19.01785  -31.60345 1.000 92.44000  ? 231 SER B CB  1 
ATOM   2820 N N   . GLY B 1 114 ? 6.19015   19.26791  -30.37797 1.000 100.68000 ? 232 GLY B N   1 
ATOM   2821 C CA  . GLY B 1 114 ? 7.19436   20.26793  -29.98654 1.000 91.81000  ? 232 GLY B CA  1 
ATOM   2822 C C   . GLY B 1 114 ? 6.53075   21.34206  -29.15839 1.000 89.63000  ? 232 GLY B C   1 
ATOM   2823 O O   . GLY B 1 114 ? 6.28555   22.40400  -29.69043 1.000 96.36000  ? 232 GLY B O   1 
ATOM   2824 N N   . GLY B 1 115 ? 6.22629   21.05424  -27.89822 1.000 92.95000  ? 233 GLY B N   1 
ATOM   2825 C CA  . GLY B 1 115 ? 5.56469   22.05637  -27.04906 1.000 83.76000  ? 233 GLY B CA  1 
ATOM   2826 C C   . GLY B 1 115 ? 5.46230   21.58156  -25.61996 1.000 86.10000  ? 233 GLY B C   1 
ATOM   2827 O O   . GLY B 1 115 ? 5.90339   20.48159  -25.34200 1.000 84.57000  ? 233 GLY B O   1 
ATOM   2828 N N   . LYS B 1 116 ? 4.88270   22.40070  -24.75481 1.000 84.55000  ? 234 LYS B N   1 
ATOM   2829 C CA  . LYS B 1 116 ? 4.74532   22.05689  -23.32471 1.000 84.05000  ? 234 LYS B CA  1 
ATOM   2830 C C   . LYS B 1 116 ? 3.79635   20.86494  -23.15813 1.000 88.10000  ? 234 LYS B C   1 
ATOM   2831 O O   . LYS B 1 116 ? 3.51484   20.50711  -22.01196 1.000 85.14000  ? 234 LYS B O   1 
ATOM   2832 C CB  . LYS B 1 116 ? 4.23269   23.28301  -22.56765 1.000 71.17000  ? 234 LYS B CB  1 
ATOM   2833 N N   . GLU B 1 117 ? 3.32386   20.25981  -24.24685 1.000 82.76000  ? 235 GLU B N   1 
ATOM   2834 C CA  . GLU B 1 117 ? 2.39891   19.14687  -24.05629 1.000 79.69000  ? 235 GLU B CA  1 
ATOM   2835 C C   . GLU B 1 117 ? 3.09704   17.85090  -23.66443 1.000 79.78000  ? 235 GLU B C   1 
ATOM   2836 O O   . GLU B 1 117 ? 2.42420   16.90598  -23.22901 1.000 82.21000  ? 235 GLU B O   1 
ATOM   2837 C CB  . GLU B 1 117 ? 1.58435   18.90672  -25.33191 1.000 77.70000  ? 235 GLU B CB  1 
ATOM   2838 C CG  . GLU B 1 117 ? 2.43782   18.46054  -26.50522 1.000 79.98000  ? 235 GLU B CG  1 
ATOM   2839 C CD  . GLU B 1 117 ? 3.06053   19.62042  -27.25565 1.000 88.70000  ? 235 GLU B CD  1 
ATOM   2840 O OE1 . GLU B 1 117 ? 2.67067   20.78746  -27.00163 1.000 85.18000  ? 235 GLU B OE1 1 
ATOM   2841 O OE2 . GLU B 1 117 ? 3.96516   19.35628  -28.07801 1.000 84.95000  ? 235 GLU B OE2 1 
ATOM   2842 N N   . ILE B 1 118 ? 4.41798   17.77384  -23.80199 1.000 78.10000  ? 236 ILE B N   1 
ATOM   2843 C CA  . ILE B 1 118 ? 5.15510   16.57187  -23.43215 1.000 72.01000  ? 236 ILE B CA  1 
ATOM   2844 C C   . ILE B 1 118 ? 5.21276   16.45407  -21.91716 1.000 67.25000  ? 236 ILE B C   1 
ATOM   2845 O O   . ILE B 1 118 ? 5.76396   15.48812  -21.38527 1.000 68.03000  ? 236 ILE B O   1 
ATOM   2846 C CB  . ILE B 1 118 ? 6.56785   16.59174  -24.02677 1.000 68.70000  ? 236 ILE B CB  1 
ATOM   2847 C CG1 . ILE B 1 118 ? 7.23102   17.94576  -23.72524 1.000 73.41000  ? 236 ILE B CG1 1 
ATOM   2848 C CG2 . ILE B 1 118 ? 6.49319   16.29955  -25.50970 1.000 72.43000  ? 236 ILE B CG2 1 
ATOM   2849 C CD1 . ILE B 1 118 ? 8.66182   18.07866  -24.19489 1.000 65.68000  ? 236 ILE B CD1 1 
ATOM   2850 N N   . PHE B 1 119 ? 4.63910   17.43418  -21.21804 1.000 68.21000  ? 237 PHE B N   1 
ATOM   2851 C CA  . PHE B 1 119 ? 4.63773   17.48437  -19.76105 1.000 69.18000  ? 237 PHE B CA  1 
ATOM   2852 C C   . PHE B 1 119 ? 3.28100   17.19250  -19.14242 1.000 61.54000  ? 237 PHE B C   1 
ATOM   2853 O O   . PHE B 1 119 ? 3.14153   17.34666  -17.92938 1.000 62.17000  ? 237 PHE B O   1 
ATOM   2854 C CB  . PHE B 1 119 ? 5.08800   18.85943  -19.25843 1.000 70.48000  ? 237 PHE B CB  1 
ATOM   2855 C CG  . PHE B 1 119 ? 6.35874   19.35331  -19.87205 1.000 76.84000  ? 237 PHE B CG  1 
ATOM   2856 C CD1 . PHE B 1 119 ? 7.47268   18.52726  -19.96143 1.000 72.59000  ? 237 PHE B CD1 1 
ATOM   2857 C CD2 . PHE B 1 119 ? 6.45258   20.65724  -20.33726 1.000 80.49000  ? 237 PHE B CD2 1 
ATOM   2858 C CE1 . PHE B 1 119 ? 8.65845   18.98915  -20.52301 1.000 76.59000  ? 237 PHE B CE1 1 
ATOM   2859 C CE2 . PHE B 1 119 ? 7.63135   21.12713  -20.89084 1.000 81.58000  ? 237 PHE B CE2 1 
ATOM   2860 C CZ  . PHE B 1 119 ? 8.73729   20.28808  -20.98621 1.000 77.07000  ? 237 PHE B CZ  1 
ATOM   2861 N N   . SER B 1 120 ? 2.27364   16.80642  -19.93393 1.000 64.76000  ? 238 SER B N   1 
ATOM   2862 C CA  . SER B 1 120 ? 0.90486   16.78653  -19.41633 1.000 62.86000  ? 238 SER B CA  1 
ATOM   2863 C C   . SER B 1 120 ? 0.78137   15.87970  -18.20015 1.000 58.26000  ? 238 SER B C   1 
ATOM   2864 O O   . SER B 1 120 ? 0.01278   16.17184  -17.27785 1.000 55.86000  ? 238 SER B O   1 
ATOM   2865 C CB  . SER B 1 120 ? -0.07262  16.32942  -20.49484 1.000 60.05000  ? 238 SER B CB  1 
ATOM   2866 O OG  . SER B 1 120 ? 0.38808   15.12932  -21.09388 1.000 64.56000  ? 238 SER B OG  1 
ATOM   2867 N N   . LEU B 1 121 ? 1.52734   14.76768  -18.18733 1.000 60.51000  ? 239 LEU B N   1 
ATOM   2868 C CA  . LEU B 1 121 ? 1.42178   13.78982  -17.11215 1.000 57.64000  ? 239 LEU B CA  1 
ATOM   2869 C C   . LEU B 1 121 ? 2.41727   13.98994  -15.99161 1.000 53.38000  ? 239 LEU B C   1 
ATOM   2870 O O   . LEU B 1 121 ? 2.28070   13.32308  -14.96646 1.000 47.96000  ? 239 LEU B O   1 
ATOM   2871 C CB  . LEU B 1 121 ? 1.58951   12.36375  -17.62403 1.000 50.92000  ? 239 LEU B CB  1 
ATOM   2872 C CG  . LEU B 1 121 ? 0.28930   11.68673  -18.05838 1.000 53.69000  ? 239 LEU B CG  1 
ATOM   2873 C CD1 . LEU B 1 121 ? 0.56287   10.47060  -18.95933 1.000 49.08000  ? 239 LEU B CD1 1 
ATOM   2874 C CD2 . LEU B 1 121 ? -0.51518  11.30092  -16.83397 1.000 45.97000  ? 239 LEU B CD2 1 
ATOM   2875 N N   . LEU B 1 122 ? 3.39023   14.88689  -16.14516 1.000 53.14000  ? 240 LEU B N   1 
ATOM   2876 C CA  . LEU B 1 122 ? 4.37070   15.07101  -15.07961 1.000 52.13000  ? 240 LEU B CA  1 
ATOM   2877 C C   . LEU B 1 122 ? 3.74530   15.44120  -13.74339 1.000 52.10000  ? 240 LEU B C   1 
ATOM   2878 O O   . LEU B 1 122 ? 4.09772   14.80433  -12.73545 1.000 55.54000  ? 240 LEU B O   1 
ATOM   2879 C CB  . LEU B 1 122 ? 5.43755   16.08492  -15.49721 1.000 59.06000  ? 240 LEU B CB  1 
ATOM   2880 C CG  . LEU B 1 122 ? 6.35906   15.53074  -16.58054 1.000 60.00000  ? 240 LEU B CG  1 
ATOM   2881 C CD1 . LEU B 1 122 ? 7.46195   16.51767  -16.92115 1.000 57.09000  ? 240 LEU B CD1 1 
ATOM   2882 C CD2 . LEU B 1 122 ? 6.92422   14.20079  -16.13161 1.000 57.35000  ? 240 LEU B CD2 1 
ATOM   2883 N N   . PRO B 1 123 ? 2.83237   16.41824  -13.64112 1.000 57.42000  ? 241 PRO B N   1 
ATOM   2884 C CA  . PRO B 1 123 ? 2.28897   16.72344  -12.30692 1.000 53.67000  ? 241 PRO B CA  1 
ATOM   2885 C C   . PRO B 1 123 ? 1.71122   15.49055  -11.64550 1.000 51.59000  ? 241 PRO B C   1 
ATOM   2886 O O   . PRO B 1 123 ? 1.91673   15.26470  -10.44756 1.000 56.80000  ? 241 PRO B O   1 
ATOM   2887 C CB  . PRO B 1 123 ? 1.21687   17.78143  -12.59259 1.000 45.55000  ? 241 PRO B CB  1 
ATOM   2888 C CG  . PRO B 1 123 ? 1.59432   18.35725  -13.90184 1.000 48.94000  ? 241 PRO B CG  1 
ATOM   2889 C CD  . PRO B 1 123 ? 2.17494   17.22813  -14.68194 1.000 53.01000  ? 241 PRO B CD  1 
ATOM   2890 N N   . HIS B 1 124 ? 1.03885   14.64446  -12.42010 1.000 49.83000  ? 242 HIS B N   1 
ATOM   2891 C CA  . HIS B 1 124 ? 0.47607   13.43856  -11.83769 1.000 49.27000  ? 242 HIS B CA  1 
ATOM   2892 C C   . HIS B 1 124 ? 1.56420   12.43357  -11.47903 1.000 50.76000  ? 242 HIS B C   1 
ATOM   2893 O O   . HIS B 1 124 ? 1.46162   11.74971  -10.45789 1.000 47.89000  ? 242 HIS B O   1 
ATOM   2894 C CB  . HIS B 1 124 ? -0.54536  12.83746  -12.78316 1.000 43.27000  ? 242 HIS B CB  1 
ATOM   2895 C CG  . HIS B 1 124 ? -0.96024  11.45552  -12.40880 1.000 47.47000  ? 242 HIS B CG  1 
ATOM   2896 N ND1 . HIS B 1 124 ? -2.00587  11.20467  -11.54631 1.000 49.50000  ? 242 HIS B ND1 1 
ATOM   2897 C CD2 . HIS B 1 124 ? -0.51046  10.24546  -12.81883 1.000 46.00000  ? 242 HIS B CD2 1 
ATOM   2898 C CE1 . HIS B 1 124 ? -2.16386  9.89769   -11.42106 1.000 45.93000  ? 242 HIS B CE1 1 
ATOM   2899 N NE2 . HIS B 1 124 ? -1.27321  9.29356   -12.18837 1.000 41.94000  ? 242 HIS B NE2 1 
ATOM   2900 N N   . MET B 1 125 ? 2.61484   12.32543  -12.29748 1.000 53.72000  ? 243 MET B N   1 
ATOM   2901 C CA  A MET B 1 125 ? 3.74597   11.47945  -11.92886 0.550 50.03000  ? 243 MET B CA  1 
ATOM   2902 C CA  B MET B 1 125 ? 3.73298   11.47045  -11.91885 0.450 49.64000  ? 243 MET B CA  1 
ATOM   2903 C C   . MET B 1 125 ? 4.39355   11.97160  -10.64520 1.000 52.33000  ? 243 MET B C   1 
ATOM   2904 O O   . MET B 1 125 ? 4.76090   11.17070  -9.77226  1.000 53.55000  ? 243 MET B O   1 
ATOM   2905 C CB  A MET B 1 125 ? 4.79149   11.45327  -13.03931 0.550 52.13000  ? 243 MET B CB  1 
ATOM   2906 C CB  B MET B 1 125 ? 4.75048   11.39627  -13.04728 0.450 51.86000  ? 243 MET B CB  1 
ATOM   2907 C CG  A MET B 1 125 ? 4.27587   11.27010  -14.42706 0.550 53.28000  ? 243 MET B CG  1 
ATOM   2908 C CG  B MET B 1 125 ? 4.12889   11.15211  -14.37198 0.450 53.27000  ? 243 MET B CG  1 
ATOM   2909 S SD  A MET B 1 125 ? 4.39957   9.58902   -15.00289 0.550 60.41000  ? 243 MET B SD  1 
ATOM   2910 S SD  B MET B 1 125 ? 3.85070   9.42007   -14.68563 0.450 58.16000  ? 243 MET B SD  1 
ATOM   2911 C CE  A MET B 1 125 ? 2.91988   8.90816   -14.24315 0.550 47.24000  ? 243 MET B CE  1 
ATOM   2912 C CE  B MET B 1 125 ? 5.13416   9.14887   -15.91515 0.450 56.07000  ? 243 MET B CE  1 
ATOM   2913 N N   . ALA B 1 126 ? 4.57064   13.28761  -10.52446 1.000 45.24000  ? 244 ALA B N   1 
ATOM   2914 C CA  . ALA B 1 126 ? 5.12519   13.82476  -9.29077  1.000 47.21000  ? 244 ALA B CA  1 
ATOM   2915 C C   . ALA B 1 126 ? 4.25271   13.47594  -8.08534  1.000 49.59000  ? 244 ALA B C   1 
ATOM   2916 O O   . ALA B 1 126 ? 4.76319   13.33508  -6.97055  1.000 48.72000  ? 244 ALA B O   1 
ATOM   2917 C CB  . ALA B 1 126 ? 5.30319   15.33074  -9.41005  1.000 45.11000  ? 244 ALA B CB  1 
ATOM   2918 N N   . ASP B 1 127 ? 2.94862   13.29896  -8.27975  1.000 47.48000  ? 245 ASP B N   1 
ATOM   2919 C CA  . ASP B 1 127 ? 2.11511   12.95214  -7.13634  1.000 45.93000  ? 245 ASP B CA  1 
ATOM   2920 C C   . ASP B 1 127 ? 2.16720   11.45718  -6.82316  1.000 44.52000  ? 245 ASP B C   1 
ATOM   2921 O O   . ASP B 1 127 ? 2.15470   11.07033  -5.64911  1.000 44.72000  ? 245 ASP B O   1 
ATOM   2922 C CB  . ASP B 1 127 ? 0.68002   13.42115  -7.37378  1.000 41.03000  ? 245 ASP B CB  1 
ATOM   2923 C CG  . ASP B 1 127 ? 0.55709   14.93516  -7.32293  1.000 55.33000  ? 245 ASP B CG  1 
ATOM   2924 O OD1 . ASP B 1 127 ? 1.28745   15.58124  -6.52833  1.000 62.69000  ? 245 ASP B OD1 1 
ATOM   2925 O OD2 . ASP B 1 127 ? -0.27522  15.48808  -8.06764  1.000 61.09000  ? 245 ASP B OD2 1 
ATOM   2926 N N   . MET B 1 128 ? 2.19472   10.60704  -7.85506  1.000 41.95000  ? 246 MET B N   1 
ATOM   2927 C CA  . MET B 1 128 ? 2.42377   9.18306   -7.64597  1.000 40.29000  ? 246 MET B CA  1 
ATOM   2928 C C   . MET B 1 128 ? 3.77105   8.93410   -6.99053  1.000 44.16000  ? 246 MET B C   1 
ATOM   2929 O O   . MET B 1 128 ? 3.86547   8.22424   -5.98747  1.000 43.80000  ? 246 MET B O   1 
ATOM   2930 C CB  . MET B 1 128 ? 2.33417   8.41688   -8.96883  1.000 44.36000  ? 246 MET B CB  1 
ATOM   2931 C CG  . MET B 1 128 ? 2.63020   6.91090   -8.79276  1.000 44.28000  ? 246 MET B CG  1 
ATOM   2932 S SD  . MET B 1 128 ? 1.57370   6.04609   -7.58218  1.000 43.75000  ? 246 MET B SD  1 
ATOM   2933 C CE  . MET B 1 128 ? 0.12227   5.67201   -8.54450  1.000 48.06000  ? 246 MET B CE  1 
ATOM   2934 N N   . SER B 1 129 ? 4.83282   9.50100   -7.55307  1.000 49.90000  ? 247 SER B N   1 
ATOM   2935 C CA  . SER B 1 129 ? 6.15006   9.25203   -6.99461  1.000 46.22000  ? 247 SER B CA  1 
ATOM   2936 C C   . SER B 1 129 ? 6.23770   9.77322   -5.56872  1.000 45.76000  ? 247 SER B C   1 
ATOM   2937 O O   . SER B 1 129 ? 6.79406   9.10332   -4.68687  1.000 41.29000  ? 247 SER B O   1 
ATOM   2938 C CB  . SER B 1 129 ? 7.21469   9.87988   -7.88816  1.000 56.95000  ? 247 SER B CB  1 
ATOM   2939 O OG  . SER B 1 129 ? 7.32413   9.15271   -9.10511  1.000 54.66000  ? 247 SER B OG  1 
ATOM   2940 N N   . THR B 1 130 ? 5.65085   10.94527  -5.30762  1.000 45.48000  ? 248 THR B N   1 
ATOM   2941 C CA  . THR B 1 130 ? 5.66946   11.47745  -3.94569  1.000 46.14000  ? 248 THR B CA  1 
ATOM   2942 C C   . THR B 1 130 ? 4.96785   10.53061  -2.97326  1.000 43.83000  ? 248 THR B C   1 
ATOM   2943 O O   . THR B 1 130 ? 5.50032   10.24173  -1.88846  1.000 43.55000  ? 248 THR B O   1 
ATOM   2944 C CB  . THR B 1 130 ? 5.05151   12.87948  -3.91561  1.000 43.79000  ? 248 THR B CB  1 
ATOM   2945 O OG1 . THR B 1 130 ? 5.80916   13.74234  -4.77906  1.000 45.86000  ? 248 THR B OG1 1 
ATOM   2946 C CG2 . THR B 1 130 ? 5.06315   13.47967  -2.50170  1.000 42.60000  ? 248 THR B CG2 1 
ATOM   2947 N N   . TYR B 1 131 ? 3.79967   10.00159  -3.35368  1.000 38.38000  ? 249 TYR B N   1 
ATOM   2948 C CA  . TYR B 1 131 ? 3.13501   9.01072   -2.50526  1.000 36.94000  ? 249 TYR B CA  1 
ATOM   2949 C C   . TYR B 1 131 ? 4.04508   7.80873   -2.26750  1.000 42.16000  ? 249 TYR B C   1 
ATOM   2950 O O   . TYR B 1 131 ? 4.21156   7.35587   -1.12751  1.000 44.61000  ? 249 TYR B O   1 
ATOM   2951 C CB  . TYR B 1 131 ? 1.81572   8.58468   -3.14263  1.000 32.96000  ? 249 TYR B CB  1 
ATOM   2952 C CG  . TYR B 1 131 ? 1.03401   7.51080   -2.39914  1.000 44.17000  ? 249 TYR B CG  1 
ATOM   2953 C CD1 . TYR B 1 131 ? 0.17648   7.84497   -1.34681  1.000 43.49000  ? 249 TYR B CD1 1 
ATOM   2954 C CD2 . TYR B 1 131 ? 1.12481   6.16175   -2.76900  1.000 45.14000  ? 249 TYR B CD2 1 
ATOM   2955 C CE1 . TYR B 1 131 ? -0.56525  6.87208   -0.66936  1.000 42.72000  ? 249 TYR B CE1 1 
ATOM   2956 C CE2 . TYR B 1 131 ? 0.38507   5.17886   -2.10555  1.000 47.72000  ? 249 TYR B CE2 1 
ATOM   2957 C CZ  . TYR B 1 131 ? -0.45246  5.54503   -1.04523  1.000 55.83000  ? 249 TYR B CZ  1 
ATOM   2958 O OH  . TYR B 1 131 ? -1.18019  4.58414   -0.36278  1.000 58.59000  ? 249 TYR B OH  1 
ATOM   2959 N N   . MET B 1 132 ? 4.68259   7.31157   -3.33871  1.000 42.65000  ? 250 MET B N   1 
ATOM   2960 C CA  . MET B 1 132 ? 5.56160   6.14955   -3.23994  1.000 38.42000  ? 250 MET B CA  1 
ATOM   2961 C C   . MET B 1 132 ? 6.73402   6.42264   -2.30448  1.000 37.90000  ? 250 MET B C   1 
ATOM   2962 O O   . MET B 1 132 ? 7.13433   5.54873   -1.53454  1.000 41.62000  ? 250 MET B O   1 
ATOM   2963 C CB  . MET B 1 132 ? 6.10999   5.77335   -4.61513  1.000 40.26000  ? 250 MET B CB  1 
ATOM   2964 C CG  . MET B 1 132 ? 5.22155   4.99325   -5.56163  1.000 40.93000  ? 250 MET B CG  1 
ATOM   2965 S SD  . MET B 1 132 ? 4.48584   3.56338   -4.80012  1.000 40.89000  ? 250 MET B SD  1 
ATOM   2966 C CE  . MET B 1 132 ? 5.60759   2.23828   -5.29043  1.000 37.83000  ? 250 MET B CE  1 
ATOM   2967 N N   . PHE B 1 133 ? 7.32202   7.62061   -2.39290  1.000 40.50000  ? 251 PHE B N   1 
ATOM   2968 C CA  . PHE B 1 133 ? 8.46040   7.97469   -1.55045  1.000 40.53000  ? 251 PHE B CA  1 
ATOM   2969 C C   . PHE B 1 133 ? 8.06804   8.08690   -0.08429  1.000 43.08000  ? 251 PHE B C   1 
ATOM   2970 O O   . PHE B 1 133 ? 8.89641   7.82299   0.79439   1.000 43.18000  ? 251 PHE B O   1 
ATOM   2971 C CB  . PHE B 1 133 ? 9.08224   9.30061   -1.99689  1.000 40.14000  ? 251 PHE B CB  1 
ATOM   2972 C CG  . PHE B 1 133 ? 9.66464   9.26641   -3.37514  1.000 44.52000  ? 251 PHE B CG  1 
ATOM   2973 C CD1 . PHE B 1 133 ? 10.26439  8.11033   -3.86525  1.000 45.06000  ? 251 PHE B CD1 1 
ATOM   2974 C CD2 . PHE B 1 133 ? 9.59231   10.38330  -4.19826  1.000 42.48000  ? 251 PHE B CD2 1 
ATOM   2975 C CE1 . PHE B 1 133 ? 10.78183  8.08014   -5.14347  1.000 45.27000  ? 251 PHE B CE1 1 
ATOM   2976 C CE2 . PHE B 1 133 ? 10.11275  10.35911  -5.47949  1.000 42.73000  ? 251 PHE B CE2 1 
ATOM   2977 C CZ  . PHE B 1 133 ? 10.70851  9.21803   -5.95559  1.000 43.94000  ? 251 PHE B CZ  1 
ATOM   2978 N N   . LYS B 1 134 ? 6.83018   8.49797   0.20820   1.000 40.88000  ? 252 LYS B N   1 
ATOM   2979 C CA  . LYS B 1 134 ? 6.39779   8.50617   1.60038   1.000 39.74000  ? 252 LYS B CA  1 
ATOM   2980 C C   . LYS B 1 134 ? 6.37299   7.08925   2.15558   1.000 40.46000  ? 252 LYS B C   1 
ATOM   2981 O O   . LYS B 1 134 ? 6.76248   6.85639   3.30745   1.000 39.94000  ? 252 LYS B O   1 
ATOM   2982 C CB  . LYS B 1 134 ? 5.02987   9.17823   1.73389   1.000 44.14000  ? 252 LYS B CB  1 
ATOM   2983 C CG  . LYS B 1 134 ? 4.96869   10.63117  1.23672   1.000 43.57000  ? 252 LYS B CG  1 
ATOM   2984 C CD  . LYS B 1 134 ? 4.01109   11.47431  2.08903   1.000 49.12000  ? 252 LYS B CD  1 
ATOM   2985 C CE  . LYS B 1 134 ? 3.33078   12.61722  1.29017   1.000 56.98000  ? 252 LYS B CE  1 
ATOM   2986 N NZ  . LYS B 1 134 ? 2.23835   12.13913  0.33972   1.000 57.84000  ? 252 LYS B NZ  1 
ATOM   2987 N N   . GLY B 1 135 ? 5.94260   6.12315   1.33890   1.000 43.64000  ? 253 GLY B N   1 
ATOM   2988 C CA  . GLY B 1 135 ? 5.98274   4.73621   1.76607   1.000 32.89000  ? 253 GLY B CA  1 
ATOM   2989 C C   . GLY B 1 135 ? 7.40182   4.24419   1.96952   1.000 44.17000  ? 253 GLY B C   1 
ATOM   2990 O O   . GLY B 1 135 ? 7.68022   3.52531   2.93649   1.000 44.45000  ? 253 GLY B O   1 
ATOM   2991 N N   . ILE B 1 136 ? 8.31443   4.62004   1.05907   1.000 39.47000  ? 254 ILE B N   1 
ATOM   2992 C CA  . ILE B 1 136 ? 9.73448   4.27902   1.19349   1.000 39.33000  ? 254 ILE B CA  1 
ATOM   2993 C C   . ILE B 1 136 ? 10.29207  4.80918   2.51518   1.000 40.74000  ? 254 ILE B C   1 
ATOM   2994 O O   . ILE B 1 136 ? 10.96438  4.09126   3.26298   1.000 41.56000  ? 254 ILE B O   1 
ATOM   2995 C CB  . ILE B 1 136 ? 10.52598  4.83683   -0.00493  1.000 41.93000  ? 254 ILE B CB  1 
ATOM   2996 C CG1 . ILE B 1 136 ? 10.05138  4.20767   -1.31664  1.000 41.22000  ? 254 ILE B CG1 1 
ATOM   2997 C CG2 . ILE B 1 136 ? 12.02406  4.66881   0.18944   1.000 41.11000  ? 254 ILE B CG2 1 
ATOM   2998 C CD1 . ILE B 1 136 ? 9.86937   2.74469   -1.25336  1.000 42.06000  ? 254 ILE B CD1 1 
ATOM   2999 N N   . ILE B 1 137 ? 10.03524  6.08322   2.81012   1.000 39.43000  ? 255 ILE B N   1 
ATOM   3000 C CA  . ILE B 1 137 ? 10.51580  6.67138   4.05383   1.000 35.82000  ? 255 ILE B CA  1 
ATOM   3001 C C   . ILE B 1 137 ? 9.92030   5.94455   5.25319   1.000 41.16000  ? 255 ILE B C   1 
ATOM   3002 O O   . ILE B 1 137 ? 10.62272  5.63566   6.22192   1.000 41.69000  ? 255 ILE B O   1 
ATOM   3003 C CB  . ILE B 1 137 ? 10.19187  8.17739   4.09377   1.000 40.13000  ? 255 ILE B CB  1 
ATOM   3004 C CG1 . ILE B 1 137 ? 10.96641  8.93022   2.99933   1.000 43.30000  ? 255 ILE B CG1 1 
ATOM   3005 C CG2 . ILE B 1 137 ? 10.50849  8.75857   5.47256   1.000 32.24000  ? 255 ILE B CG2 1 
ATOM   3006 C CD1 . ILE B 1 137 ? 10.36128  10.27719  2.60642   1.000 35.54000  ? 255 ILE B CD1 1 
ATOM   3007 N N   . SER B 1 138 ? 8.60628   5.68559   5.22280   1.000 41.04000  ? 256 SER B N   1 
ATOM   3008 C CA  . SER B 1 138 ? 7.98674   4.95476   6.32417   1.000 40.71000  ? 256 SER B CA  1 
ATOM   3009 C C   . SER B 1 138 ? 8.62076   3.58476   6.47007   1.000 45.69000  ? 256 SER B C   1 
ATOM   3010 O O   . SER B 1 138 ? 8.84924   3.10790   7.59004   1.000 49.94000  ? 256 SER B O   1 
ATOM   3011 C CB  . SER B 1 138 ? 6.48164   4.80877   6.09984   1.000 39.51000  ? 256 SER B CB  1 
ATOM   3012 O OG  . SER B 1 138 ? 5.85464   6.07778   6.01895   1.000 46.19000  ? 256 SER B OG  1 
ATOM   3013 N N   . PHE B 1 139 ? 8.92925   2.95060   5.33602   1.000 43.56000  ? 257 PHE B N   1 
ATOM   3014 C CA  . PHE B 1 139 ? 9.54421   1.63358   5.33693   1.000 37.92000  ? 257 PHE B CA  1 
ATOM   3015 C C   . PHE B 1 139 ? 10.88552  1.66463   6.05334   1.000 43.05000  ? 257 PHE B C   1 
ATOM   3016 O O   . PHE B 1 139 ? 11.18485  0.77473   6.85733   1.000 44.04000  ? 257 PHE B O   1 
ATOM   3017 C CB  . PHE B 1 139 ? 9.68156   1.14238   3.88794   1.000 43.83000  ? 257 PHE B CB  1 
ATOM   3018 C CG  . PHE B 1 139 ? 10.59046  -0.02467  3.72369   1.000 38.06000  ? 257 PHE B CG  1 
ATOM   3019 C CD1 . PHE B 1 139 ? 10.16456  -1.30061  4.05105   1.000 35.96000  ? 257 PHE B CD1 1 
ATOM   3020 C CD2 . PHE B 1 139 ? 11.88125  0.15323   3.24611   1.000 37.79000  ? 257 PHE B CD2 1 
ATOM   3021 C CE1 . PHE B 1 139 ? 11.01846  -2.38066  3.90882   1.000 39.33000  ? 257 PHE B CE1 1 
ATOM   3022 C CE2 . PHE B 1 139 ? 12.74716  -0.92082  3.11487   1.000 37.91000  ? 257 PHE B CE2 1 
ATOM   3023 C CZ  . PHE B 1 139 ? 12.31826  -2.18976  3.43623   1.000 32.74000  ? 257 PHE B CZ  1 
ATOM   3024 N N   . ALA B 1 140 ? 11.69944  2.69357   5.79885   1.000 42.40000  ? 258 ALA B N   1 
ATOM   3025 C CA  . ALA B 1 140 ? 12.98574  2.78263   6.48127   1.000 37.31000  ? 258 ALA B CA  1 
ATOM   3026 C C   . ALA B 1 140 ? 12.79740  2.99183   7.97733   1.000 45.02000  ? 258 ALA B C   1 
ATOM   3027 O O   . ALA B 1 140 ? 13.47974  2.34892   8.78812   1.000 43.13000  ? 258 ALA B O   1 
ATOM   3028 C CB  . ALA B 1 140 ? 13.82152  3.90752   5.88176   1.000 38.41000  ? 258 ALA B CB  1 
ATOM   3029 N N   . LYS B 1 141 ? 11.85760  3.87191   8.35662   1.000 45.57000  ? 259 LYS B N   1 
ATOM   3030 C CA  . LYS B 1 141 ? 11.62722  4.20710   9.76268   1.000 42.43000  ? 259 LYS B CA  1 
ATOM   3031 C C   . LYS B 1 141 ? 11.29655  2.97523   10.59399  1.000 45.26000  ? 259 LYS B C   1 
ATOM   3032 O O   . LYS B 1 141 ? 11.72705  2.86137   11.74581  1.000 51.31000  ? 259 LYS B O   1 
ATOM   3033 C CB  . LYS B 1 141 ? 10.48031  5.21316   9.90204   1.000 46.93000  ? 259 LYS B CB  1 
ATOM   3034 C CG  . LYS B 1 141 ? 10.76015  6.62809   9.43873   1.000 41.12000  ? 259 LYS B CG  1 
ATOM   3035 C CD  . LYS B 1 141 ? 9.45515   7.40512   9.37320   1.000 44.43000  ? 259 LYS B CD  1 
ATOM   3036 C CE  . LYS B 1 141 ? 8.83476   7.54632   10.77145  1.000 56.53000  ? 259 LYS B CE  1 
ATOM   3037 N NZ  . LYS B 1 141 ? 7.45479   8.13237   10.78397  1.000 55.80000  ? 259 LYS B NZ  1 
ATOM   3038 N N   . VAL B 1 142 ? 10.49928  2.05618   10.04846  1.000 46.98000  ? 260 VAL B N   1 
ATOM   3039 C CA  . VAL B 1 142 ? 10.07759  0.90530   10.83979  1.000 50.78000  ? 260 VAL B CA  1 
ATOM   3040 C C   . VAL B 1 142 ? 11.23168  -0.06370  11.10742  1.000 51.51000  ? 260 VAL B C   1 
ATOM   3041 O O   . VAL B 1 142 ? 11.18808  -0.82757  12.08054  1.000 55.37000  ? 260 VAL B O   1 
ATOM   3042 C CB  . VAL B 1 142 ? 8.87826   0.24024   10.13841  1.000 49.92000  ? 260 VAL B CB  1 
ATOM   3043 C CG1 . VAL B 1 142 ? 8.67043   -1.16569  10.62369  1.000 54.06000  ? 260 VAL B CG1 1 
ATOM   3044 C CG2 . VAL B 1 142 ? 7.62441   1.05131   10.42585  1.000 60.47000  ? 260 VAL B CG2 1 
ATOM   3045 N N   . ILE B 1 143 ? 12.29633  0.00616   10.31595  1.000 53.84000  ? 261 ILE B N   1 
ATOM   3046 C CA  . ILE B 1 143 ? 13.41835  -0.92286  10.41358  1.000 52.46000  ? 261 ILE B CA  1 
ATOM   3047 C C   . ILE B 1 143 ? 14.37584  -0.46575  11.51010  1.000 58.93000  ? 261 ILE B C   1 
ATOM   3048 O O   . ILE B 1 143 ? 14.87287  0.67324   11.48773  1.000 56.76000  ? 261 ILE B O   1 
ATOM   3049 C CB  . ILE B 1 143 ? 14.13075  -1.03107  9.05628   1.000 47.28000  ? 261 ILE B CB  1 
ATOM   3050 C CG1 . ILE B 1 143 ? 13.13528  -1.48218  7.99478   1.000 45.65000  ? 261 ILE B CG1 1 
ATOM   3051 C CG2 . ILE B 1 143 ? 15.31175  -1.97109  9.12589   1.000 54.74000  ? 261 ILE B CG2 1 
ATOM   3052 C CD1 . ILE B 1 143 ? 13.70167  -1.50438  6.60453   1.000 46.71000  ? 261 ILE B CD1 1 
ATOM   3053 N N   . SER B 1 144 ? 14.66523  -1.37363  12.45410  1.000 60.04000  ? 262 SER B N   1 
ATOM   3054 C CA  . SER B 1 144 ? 15.48575  -1.04150  13.62069  1.000 57.26000  ? 262 SER B CA  1 
ATOM   3055 C C   . SER B 1 144 ? 16.87159  -0.54959  13.22402  1.000 55.65000  ? 262 SER B C   1 
ATOM   3056 O O   . SER B 1 144 ? 17.36085  0.44847   13.76168  1.000 64.03000  ? 262 SER B O   1 
ATOM   3057 C CB  . SER B 1 144 ? 15.61210  -2.25638  14.52780  1.000 50.39000  ? 262 SER B CB  1 
ATOM   3058 O OG  . SER B 1 144 ? 16.04274  -3.37849  13.77576  1.000 56.59000  ? 262 SER B OG  1 
ATOM   3059 N N   . TYR B 1 145 ? 17.53216  -1.24374  12.29483  1.000 54.63000  ? 263 TYR B N   1 
ATOM   3060 C CA  . TYR B 1 145 ? 18.88501  -0.84283  11.92818  1.000 55.26000  ? 263 TYR B CA  1 
ATOM   3061 C C   . TYR B 1 145 ? 18.91878  0.53609   11.30798  1.000 57.18000  ? 263 TYR B C   1 
ATOM   3062 O O   . TYR B 1 145 ? 19.97880  1.17106   11.29944  1.000 64.42000  ? 263 TYR B O   1 
ATOM   3063 C CB  . TYR B 1 145 ? 19.50656  -1.84997  10.97105  1.000 56.89000  ? 263 TYR B CB  1 
ATOM   3064 C CG  . TYR B 1 145 ? 19.29772  -3.26191  11.41633  1.000 65.03000  ? 263 TYR B CG  1 
ATOM   3065 C CD1 . TYR B 1 145 ? 20.00917  -3.77878  12.49908  1.000 74.22000  ? 263 TYR B CD1 1 
ATOM   3066 C CD2 . TYR B 1 145 ? 18.38241  -4.08197  10.77284  1.000 63.88000  ? 263 TYR B CD2 1 
ATOM   3067 C CE1 . TYR B 1 145 ? 19.81432  -5.09372  12.92835  1.000 75.88000  ? 263 TYR B CE1 1 
ATOM   3068 C CE2 . TYR B 1 145 ? 18.18555  -5.39090  11.18810  1.000 69.47000  ? 263 TYR B CE2 1 
ATOM   3069 C CZ  . TYR B 1 145 ? 18.90101  -5.89278  12.26785  1.000 78.80000  ? 263 TYR B CZ  1 
ATOM   3070 O OH  . TYR B 1 145 ? 18.69615  -7.19372  12.68611  1.000 90.92000  ? 263 TYR B OH  1 
ATOM   3071 N N   . PHE B 1 146 ? 17.78158  1.01406   10.80242  1.000 53.42000  ? 264 PHE B N   1 
ATOM   3072 C CA  . PHE B 1 146 ? 17.71036  2.33998   10.21527  1.000 52.31000  ? 264 PHE B CA  1 
ATOM   3073 C C   . PHE B 1 146 ? 17.38584  3.42213   11.23627  1.000 52.27000  ? 264 PHE B C   1 
ATOM   3074 O O   . PHE B 1 146 ? 17.98285  4.50010   11.18886  1.000 51.69000  ? 264 PHE B O   1 
ATOM   3075 C CB  . PHE B 1 146 ? 16.67287  2.36686   9.09272   1.000 48.02000  ? 264 PHE B CB  1 
ATOM   3076 C CG  . PHE B 1 146 ? 16.71955  3.61675   8.27753   1.000 42.93000  ? 264 PHE B CG  1 
ATOM   3077 C CD1 . PHE B 1 146 ? 17.55608  3.70758   7.17915   1.000 42.99000  ? 264 PHE B CD1 1 
ATOM   3078 C CD2 . PHE B 1 146 ? 15.94774  4.70382   8.61672   1.000 41.66000  ? 264 PHE B CD2 1 
ATOM   3079 C CE1 . PHE B 1 146 ? 17.61679  4.85448   6.42898   1.000 42.02000  ? 264 PHE B CE1 1 
ATOM   3080 C CE2 . PHE B 1 146 ? 15.99744  5.85672   7.86355   1.000 47.27000  ? 264 PHE B CE2 1 
ATOM   3081 C CZ  . PHE B 1 146 ? 16.83296  5.92855   6.76517   1.000 47.51000  ? 264 PHE B CZ  1 
ATOM   3082 N N   . ARG B 1 147 ? 16.44123  3.18128   12.14971  1.000 54.78000  ? 265 ARG B N   1 
ATOM   3083 C CA  . ARG B 1 147 ? 16.07466  4.25641   13.06273  1.000 57.11000  ? 265 ARG B CA  1 
ATOM   3084 C C   . ARG B 1 147 ? 17.11215  4.46553   14.16325  1.000 59.41000  ? 265 ARG B C   1 
ATOM   3085 O O   . ARG B 1 147 ? 17.05248  5.48662   14.85514  1.000 65.97000  ? 265 ARG B O   1 
ATOM   3086 C CB  . ARG B 1 147 ? 14.67192  4.02653   13.66537  1.000 52.11000  ? 265 ARG B CB  1 
ATOM   3087 C CG  . ARG B 1 147 ? 14.46823  2.74165   14.46463  1.000 65.75000  ? 265 ARG B CG  1 
ATOM   3088 C CD  . ARG B 1 147 ? 13.18361  2.82080   15.34018  1.000 61.10000  ? 265 ARG B CD  1 
ATOM   3089 N NE  . ARG B 1 147 ? 12.42657  1.56582   15.31768  1.000 65.23000  ? 265 ARG B NE  1 
ATOM   3090 C CZ  . ARG B 1 147 ? 12.80280  0.44289   15.93867  1.000 81.22000  ? 265 ARG B CZ  1 
ATOM   3091 N NH1 . ARG B 1 147 ? 12.05273  -0.66109  15.85014  1.000 73.16000  ? 265 ARG B NH1 1 
ATOM   3092 N NH2 . ARG B 1 147 ? 13.92612  0.41696   16.65918  1.000 79.96000  ? 265 ARG B NH2 1 
ATOM   3093 N N   . ASP B 1 148 ? 18.08619  3.56052   14.30994  1.000 56.32000  ? 266 ASP B N   1 
ATOM   3094 C CA  . ASP B 1 148 ? 19.19660  3.77161   15.23343  1.000 58.83000  ? 266 ASP B CA  1 
ATOM   3095 C C   . ASP B 1 148 ? 20.31736  4.61349   14.63583  1.000 59.03000  ? 266 ASP B C   1 
ATOM   3096 O O   . ASP B 1 148 ? 21.31567  4.85555   15.31936  1.000 70.78000  ? 266 ASP B O   1 
ATOM   3097 C CB  . ASP B 1 148 ? 19.77676  2.42765   15.70236  1.000 60.35000  ? 266 ASP B CB  1 
ATOM   3098 C CG  . ASP B 1 148 ? 18.87218  1.70781   16.71885  1.000 72.66000  ? 266 ASP B CG  1 
ATOM   3099 O OD1 . ASP B 1 148 ? 17.82838  2.27990   17.13623  1.000 67.93000  ? 266 ASP B OD1 1 
ATOM   3100 O OD2 . ASP B 1 148 ? 19.20731  0.56085   17.09986  1.000 69.21000  ? 266 ASP B OD2 1 
ATOM   3101 N N   . LEU B 1 149 ? 20.19184  5.05233   13.40383  1.000 57.09000  ? 267 LEU B N   1 
ATOM   3102 C CA  . LEU B 1 149 ? 21.27357  5.77021   12.74526  1.000 54.26000  ? 267 LEU B CA  1 
ATOM   3103 C C   . LEU B 1 149 ? 21.14973  7.26425   13.00811  1.000 55.46000  ? 267 LEU B C   1 
ATOM   3104 O O   . LEU B 1 149 ? 20.04183  7.77331   13.19753  1.000 61.36000  ? 267 LEU B O   1 
ATOM   3105 C CB  . LEU B 1 149 ? 21.24690  5.50901   11.23230  1.000 56.77000  ? 267 LEU B CB  1 
ATOM   3106 C CG  . LEU B 1 149 ? 21.65162  4.13392   10.68331  1.000 51.95000  ? 267 LEU B CG  1 
ATOM   3107 C CD1 . LEU B 1 149 ? 21.52096  4.09273   9.17137   1.000 45.69000  ? 267 LEU B CD1 1 
ATOM   3108 C CD2 . LEU B 1 149 ? 23.07278  3.81893   11.06173  1.000 45.54000  ? 267 LEU B CD2 1 
ATOM   3109 N N   . PRO B 1 150 ? 22.26877  7.98622   13.04153  1.000 55.32000  ? 268 PRO B N   1 
ATOM   3110 C CA  . PRO B 1 150 ? 22.19986  9.45124   13.15836  1.000 52.65000  ? 268 PRO B CA  1 
ATOM   3111 C C   . PRO B 1 150 ? 21.22744  10.03413  12.13971  1.000 54.88000  ? 268 PRO B C   1 
ATOM   3112 O O   . PRO B 1 150 ? 21.19492  9.61798   10.98078  1.000 59.17000  ? 268 PRO B O   1 
ATOM   3113 C CB  . PRO B 1 150 ? 23.64175  9.89616   12.87767  1.000 53.03000  ? 268 PRO B CB  1 
ATOM   3114 C CG  . PRO B 1 150 ? 24.47985  8.70817   13.18046  1.000 54.79000  ? 268 PRO B CG  1 
ATOM   3115 C CD  . PRO B 1 150 ? 23.65069  7.49216   12.90599  1.000 54.88000  ? 268 PRO B CD  1 
ATOM   3116 N N   . ILE B 1 151 ? 20.43765  11.01921  12.56892  1.000 53.24000  ? 269 ILE B N   1 
ATOM   3117 C CA  . ILE B 1 151 ? 19.39129  11.53513  11.69331  1.000 54.71000  ? 269 ILE B CA  1 
ATOM   3118 C C   . ILE B 1 151 ? 19.97475  12.13894  10.42397  1.000 60.83000  ? 269 ILE B C   1 
ATOM   3119 O O   . ILE B 1 151 ? 19.30630  12.15082  9.38226   1.000 59.62000  ? 269 ILE B O   1 
ATOM   3120 C CB  . ILE B 1 151 ? 18.49364  12.55125  12.43156  1.000 63.82000  ? 269 ILE B CB  1 
ATOM   3121 C CG1 . ILE B 1 151 ? 17.17132  12.71119  11.68212  1.000 65.50000  ? 269 ILE B CG1 1 
ATOM   3122 C CG2 . ILE B 1 151 ? 19.15973  13.92325  12.54109  1.000 63.18000  ? 269 ILE B CG2 1 
ATOM   3123 C CD1 . ILE B 1 151 ? 16.02671  13.11235  12.56457  1.000 61.74000  ? 269 ILE B CD1 1 
ATOM   3124 N N   . GLU B 1 152 ? 21.21379  12.65591  10.47936  1.000 63.03000  ? 270 GLU B N   1 
ATOM   3125 C CA  . GLU B 1 152 ? 21.84228  13.17373  9.26402   1.000 65.75000  ? 270 GLU B CA  1 
ATOM   3126 C C   . GLU B 1 152 ? 22.04380  12.05459  8.25308   1.000 63.59000  ? 270 GLU B C   1 
ATOM   3127 O O   . GLU B 1 152 ? 21.79728  12.22343  7.04917   1.000 57.21000  ? 270 GLU B O   1 
ATOM   3128 C CB  . GLU B 1 152 ? 23.19043  13.83073  9.58034   1.000 72.78000  ? 270 GLU B CB  1 
ATOM   3129 C CG  . GLU B 1 152 ? 23.15266  15.29479  9.98816   1.000 76.50000  ? 270 GLU B CG  1 
ATOM   3130 C CD  . GLU B 1 152 ? 22.37923  15.52898  11.27547  1.000 93.37000  ? 270 GLU B CD  1 
ATOM   3131 O OE1 . GLU B 1 152 ? 22.67765  14.84411  12.28343  1.000 90.79000  ? 270 GLU B OE1 1 
ATOM   3132 O OE2 . GLU B 1 152 ? 21.49726  16.41901  11.29174  1.000 88.08000  ? 270 GLU B OE2 1 
ATOM   3133 N N   . ASP B 1 153 ? 22.47598  10.89364  8.73405   1.000 54.92000  ? 271 ASP B N   1 
ATOM   3134 C CA  . ASP B 1 153 ? 22.68955  9.77751   7.83110   1.000 56.07000  ? 271 ASP B CA  1 
ATOM   3135 C C   . ASP B 1 153 ? 21.36831  9.19848   7.33576   1.000 54.44000  ? 271 ASP B C   1 
ATOM   3136 O O   . ASP B 1 153 ? 21.25579  8.82633   6.16386   1.000 54.98000  ? 271 ASP B O   1 
ATOM   3137 C CB  . ASP B 1 153 ? 23.55882  8.73758   8.52286   1.000 48.70000  ? 271 ASP B CB  1 
ATOM   3138 C CG  . ASP B 1 153 ? 25.01877  9.06751   8.37918   1.000 58.05000  ? 271 ASP B CG  1 
ATOM   3139 O OD1 . ASP B 1 153 ? 25.31766  10.24246  8.05489   1.000 67.51000  ? 271 ASP B OD1 1 
ATOM   3140 O OD2 . ASP B 1 153 ? 25.86182  8.17751   8.56093   1.000 57.06000  ? 271 ASP B OD2 1 
ATOM   3141 N N   . GLN B 1 154 ? 20.35269  9.13663   8.20121   1.000 49.30000  ? 272 GLN B N   1 
ATOM   3142 C CA  . GLN B 1 154 ? 19.02748  8.71361   7.76184   1.000 46.42000  ? 272 GLN B CA  1 
ATOM   3143 C C   . GLN B 1 154 ? 18.57798  9.52546   6.54893   1.000 51.60000  ? 272 GLN B C   1 
ATOM   3144 O O   . GLN B 1 154 ? 18.14352  8.96434   5.53620   1.000 49.13000  ? 272 GLN B O   1 
ATOM   3145 C CB  . GLN B 1 154 ? 18.02299  8.84080   8.91227   1.000 47.76000  ? 272 GLN B CB  1 
ATOM   3146 C CG  . GLN B 1 154 ? 18.28747  7.87694   10.07328  1.000 46.99000  ? 272 GLN B CG  1 
ATOM   3147 C CD  . GLN B 1 154 ? 17.19894  7.89712   11.14875  1.000 50.37000  ? 272 GLN B CD  1 
ATOM   3148 O OE1 . GLN B 1 154 ? 16.16789  8.52913   10.98612  1.000 58.26000  ? 272 GLN B OE1 1 
ATOM   3149 N NE2 . GLN B 1 154 ? 17.43240  7.19526   12.25374  1.000 55.92000  ? 272 GLN B NE2 1 
ATOM   3150 N N   . ILE B 1 155 ? 18.71205  10.85347  6.62670   1.000 57.40000  ? 273 ILE B N   1 
ATOM   3151 C CA  . ILE B 1 155 ? 18.40758  11.72333  5.48871   1.000 47.24000  ? 273 ILE B CA  1 
ATOM   3152 C C   . ILE B 1 155 ? 19.25104  11.34014  4.27840   1.000 50.05000  ? 273 ILE B C   1 
ATOM   3153 O O   . ILE B 1 155 ? 18.73455  11.16001  3.17064   1.000 51.29000  ? 273 ILE B O   1 
ATOM   3154 C CB  . ILE B 1 155 ? 18.63380  13.19537  5.87142   1.000 57.61000  ? 273 ILE B CB  1 
ATOM   3155 C CG1 . ILE B 1 155 ? 17.52222  13.66953  6.80784   1.000 58.39000  ? 273 ILE B CG1 1 
ATOM   3156 C CG2 . ILE B 1 155 ? 18.79427  14.08420  4.61423   1.000 49.29000  ? 273 ILE B CG2 1 
ATOM   3157 C CD1 . ILE B 1 155 ? 17.52436  15.16056  7.02664   1.000 63.40000  ? 273 ILE B CD1 1 
ATOM   3158 N N   . SER B 1 156 ? 20.56912  11.23413  4.46383   1.000 52.37000  ? 274 SER B N   1 
ATOM   3159 C CA  . SER B 1 156 ? 21.44262  10.98695  3.32249   1.000 51.64000  ? 274 SER B CA  1 
ATOM   3160 C C   . SER B 1 156 ? 21.09828  9.66287   2.65581   1.000 46.75000  ? 274 SER B C   1 
ATOM   3161 O O   . SER B 1 156 ? 21.02674  9.57371   1.42386   1.000 48.05000  ? 274 SER B O   1 
ATOM   3162 C CB  . SER B 1 156 ? 22.90381  11.01296  3.76984   1.000 53.13000  ? 274 SER B CB  1 
ATOM   3163 O OG  . SER B 1 156 ? 23.21911  12.26303  4.36254   1.000 64.81000  ? 274 SER B OG  1 
ATOM   3164 N N   . LEU B 1 157 ? 20.84261  8.63498   3.46306   1.000 42.72000  ? 275 LEU B N   1 
ATOM   3165 C CA  . LEU B 1 157 ? 20.50434  7.31792   2.93539   1.000 43.56000  ? 275 LEU B CA  1 
ATOM   3166 C C   . LEU B 1 157 ? 19.21598  7.36285   2.11894   1.000 44.67000  ? 275 LEU B C   1 
ATOM   3167 O O   . LEU B 1 157 ? 19.14748  6.81671   1.01104   1.000 40.46000  ? 275 LEU B O   1 
ATOM   3168 C CB  . LEU B 1 157 ? 20.37781  6.33308   4.09957   1.000 45.97000  ? 275 LEU B CB  1 
ATOM   3169 C CG  . LEU B 1 157 ? 21.68703  5.76111   4.63708   1.000 44.99000  ? 275 LEU B CG  1 
ATOM   3170 C CD1 . LEU B 1 157 ? 21.42247  4.74327   5.72133   1.000 44.11000  ? 275 LEU B CD1 1 
ATOM   3171 C CD2 . LEU B 1 157 ? 22.49951  5.12794   3.49581   1.000 45.33000  ? 275 LEU B CD2 1 
ATOM   3172 N N   . LEU B 1 158 ? 18.18523  8.02896   2.64730   1.000 48.11000  ? 276 LEU B N   1 
ATOM   3173 C CA  . LEU B 1 158 ? 16.92492  8.14490   1.92284   1.000 44.17000  ? 276 LEU B CA  1 
ATOM   3174 C C   . LEU B 1 158 ? 17.08141  9.03373   0.69565   1.000 46.26000  ? 276 LEU B C   1 
ATOM   3175 O O   . LEU B 1 158 ? 16.47394  8.76961   -0.35405  1.000 48.41000  ? 276 LEU B O   1 
ATOM   3176 C CB  . LEU B 1 158 ? 15.83534  8.67505   2.85624   1.000 41.96000  ? 276 LEU B CB  1 
ATOM   3177 C CG  . LEU B 1 158 ? 15.06566  7.60918   3.65072   1.000 40.44000  ? 276 LEU B CG  1 
ATOM   3178 C CD1 . LEU B 1 158 ? 14.19814  8.25235   4.71901   1.000 44.25000  ? 276 LEU B CD1 1 
ATOM   3179 C CD2 . LEU B 1 158 ? 14.20524  6.77009   2.74921   1.000 42.25000  ? 276 LEU B CD2 1 
ATOM   3180 N N   . LYS B 1 159 ? 17.89449  10.08972  0.80815   1.000 47.44000  ? 277 LYS B N   1 
ATOM   3181 C CA  . LYS B 1 159 ? 18.18801  10.93656  -0.34309  1.000 42.98000  ? 277 LYS B CA  1 
ATOM   3182 C C   . LYS B 1 159 ? 18.76149  10.09439  -1.47623  1.000 46.22000  ? 277 LYS B C   1 
ATOM   3183 O O   . LYS B 1 159 ? 18.39299  10.26824  -2.64209  1.000 51.04000  ? 277 LYS B O   1 
ATOM   3184 C CB  . LYS B 1 159 ? 19.16623  12.04458  0.07634   1.000 48.70000  ? 277 LYS B CB  1 
ATOM   3185 C CG  . LYS B 1 159 ? 18.70919  13.50957  -0.12566  1.000 59.53000  ? 277 LYS B CG  1 
ATOM   3186 C CD  . LYS B 1 159 ? 19.88325  14.52654  -0.04831  1.000 55.30000  ? 277 LYS B CD  1 
ATOM   3187 C CE  . LYS B 1 159 ? 19.96374  15.43338  -1.28546  1.000 51.84000  ? 277 LYS B CE  1 
ATOM   3188 N N   . GLY B 1 160 ? 19.61261  9.12441   -1.14247  1.000 41.84000  ? 278 GLY B N   1 
ATOM   3189 C CA  . GLY B 1 160 ? 20.28714  8.33525   -2.15866  1.000 45.15000  ? 278 GLY B CA  1 
ATOM   3190 C C   . GLY B 1 160 ? 19.60287  7.08720   -2.69619  1.000 49.19000  ? 278 GLY B C   1 
ATOM   3191 O O   . GLY B 1 160 ? 19.92437  6.66204   -3.80927  1.000 46.43000  ? 278 GLY B O   1 
ATOM   3192 N N   . ALA B 1 161 ? 18.67018  6.48233   -1.94970  1.000 44.71000  ? 279 ALA B N   1 
ATOM   3193 C CA  . ALA B 1 161 ? 17.99794  5.27528   -2.41525  1.000 42.78000  ? 279 ALA B CA  1 
ATOM   3194 C C   . ALA B 1 161 ? 16.52979  5.46928   -2.76863  1.000 44.31000  ? 279 ALA B C   1 
ATOM   3195 O O   . ALA B 1 161 ? 15.87860  4.48225   -3.12722  1.000 42.20000  ? 279 ALA B O   1 
ATOM   3196 C CB  . ALA B 1 161 ? 18.10236  4.15342   -1.37014  1.000 38.26000  ? 279 ALA B CB  1 
ATOM   3197 N N   . ALA B 1 162 ? 15.98986  6.69431   -2.69356  1.000 39.51000  ? 280 ALA B N   1 
ATOM   3198 C CA  . ALA B 1 162 ? 14.54080  6.87833   -2.83995  1.000 37.63000  ? 280 ALA B CA  1 
ATOM   3199 C C   . ALA B 1 162 ? 14.02620  6.36517   -4.17966  1.000 37.06000  ? 280 ALA B C   1 
ATOM   3200 O O   . ALA B 1 162 ? 13.09615  5.55319   -4.22915  1.000 42.56000  ? 280 ALA B O   1 
ATOM   3201 C CB  . ALA B 1 162 ? 14.16392  8.34537   -2.67198  1.000 41.50000  ? 280 ALA B CB  1 
ATOM   3202 N N   . PHE B 1 163 ? 14.58473  6.87000   -5.28097  1.000 43.24000  ? 281 PHE B N   1 
ATOM   3203 C CA  . PHE B 1 163 ? 14.19414  6.39484   -6.60774  1.000 36.28000  ? 281 PHE B CA  1 
ATOM   3204 C C   . PHE B 1 163 ? 14.35405  4.88482   -6.70361  1.000 40.68000  ? 281 PHE B C   1 
ATOM   3205 O O   . PHE B 1 163 ? 13.45382  4.17879   -7.17612  1.000 37.42000  ? 281 PHE B O   1 
ATOM   3206 C CB  . PHE B 1 163 ? 15.04870  7.10867   -7.65521  1.000 37.27000  ? 281 PHE B CB  1 
ATOM   3207 C CG  . PHE B 1 163 ? 14.80008  6.66949   -9.05704  1.000 40.09000  ? 281 PHE B CG  1 
ATOM   3208 C CD1 . PHE B 1 163 ? 13.71879  7.15243   -9.76063  1.000 40.30000  ? 281 PHE B CD1 1 
ATOM   3209 C CD2 . PHE B 1 163 ? 15.64678  5.75539   -9.67129  1.000 41.51000  ? 281 PHE B CD2 1 
ATOM   3210 C CE1 . PHE B 1 163 ? 13.49322  6.74027   -11.03948 1.000 41.48000  ? 281 PHE B CE1 1 
ATOM   3211 C CE2 . PHE B 1 163 ? 15.41421  5.33322   -10.95913 1.000 39.01000  ? 281 PHE B CE2 1 
ATOM   3212 C CZ  . PHE B 1 163 ? 14.34793  5.82416   -11.64173 1.000 38.28000  ? 281 PHE B CZ  1 
ATOM   3213 N N   . GLU B 1 164 ? 15.48225  4.36785   -6.21203  1.000 39.65000  ? 282 GLU B N   1 
ATOM   3214 C CA  . GLU B 1 164 ? 15.75916  2.94383   -6.32996  1.000 41.32000  ? 282 GLU B CA  1 
ATOM   3215 C C   . GLU B 1 164 ? 14.69843  2.09895   -5.63838  1.000 35.27000  ? 282 GLU B C   1 
ATOM   3216 O O   . GLU B 1 164 ? 14.16915  1.15589   -6.23103  1.000 38.13000  ? 282 GLU B O   1 
ATOM   3217 C CB  . GLU B 1 164 ? 17.13939  2.64386   -5.76852  1.000 37.25000  ? 282 GLU B CB  1 
ATOM   3218 C CG  . GLU B 1 164 ? 18.22404  3.23372   -6.61007  1.000 36.59000  ? 282 GLU B CG  1 
ATOM   3219 C CD  . GLU B 1 164 ? 19.57031  3.02676   -5.98563  1.000 38.18000  ? 282 GLU B CD  1 
ATOM   3220 O OE1 . GLU B 1 164 ? 19.73657  1.98684   -5.32457  1.000 42.61000  ? 282 GLU B OE1 1 
ATOM   3221 O OE2 . GLU B 1 164 ? 20.46226  3.87371   -6.16114  1.000 38.02000  ? 282 GLU B OE2 1 
ATOM   3222 N N   . LEU B 1 165 ? 14.39699  2.39613   -4.37229  1.000 37.41000  ? 283 LEU B N   1 
ATOM   3223 C CA  . LEU B 1 165 ? 13.35328  1.65126   -3.66674  1.000 36.98000  ? 283 LEU B CA  1 
ATOM   3224 C C   . LEU B 1 165 ? 11.98002  1.89522   -4.28117  1.000 40.33000  ? 283 LEU B C   1 
ATOM   3225 O O   . LEU B 1 165 ? 11.12299  0.99624   -4.28968  1.000 33.44000  ? 283 LEU B O   1 
ATOM   3226 C CB  . LEU B 1 165 ? 13.35094  2.00146   -2.17978  1.000 38.47000  ? 283 LEU B CB  1 
ATOM   3227 C CG  . LEU B 1 165 ? 14.38032  1.29255   -1.26414  1.000 47.70000  ? 283 LEU B CG  1 
ATOM   3228 C CD1 . LEU B 1 165 ? 15.75406  1.19843   -1.84672  1.000 41.59000  ? 283 LEU B CD1 1 
ATOM   3229 C CD2 . LEU B 1 165 ? 14.48494  1.96073   0.10873   1.000 49.32000  ? 283 LEU B CD2 1 
ATOM   3230 N N   . CYS B 1 166 ? 11.75981  3.08015   -4.84323  1.000 38.10000  ? 284 CYS B N   1 
ATOM   3231 C CA  . CYS B 1 166 ? 10.51750  3.29209   -5.57172  1.000 40.00000  ? 284 CYS B CA  1 
ATOM   3232 C C   . CYS B 1 166 ? 10.41795  2.34993   -6.76355  1.000 36.73000  ? 284 CYS B C   1 
ATOM   3233 O O   . CYS B 1 166 ? 9.40885   1.65994   -6.94402  1.000 42.81000  ? 284 CYS B O   1 
ATOM   3234 C CB  . CYS B 1 166 ? 10.40335  4.74103   -6.02286  1.000 42.79000  ? 284 CYS B CB  1 
ATOM   3235 S SG  . CYS B 1 166 ? 8.80902   5.11598   -6.79022  1.000 40.61000  ? 284 CYS B SG  1 
ATOM   3236 N N   . GLN B 1 167 ? 11.46159  2.28779   -7.57800  1.000 34.81000  ? 285 GLN B N   1 
ATOM   3237 C CA  . GLN B 1 167 ? 11.39205  1.43964   -8.75885  1.000 35.06000  ? 285 GLN B CA  1 
ATOM   3238 C C   . GLN B 1 167 ? 11.32117  -0.04131  -8.38062  1.000 38.81000  ? 285 GLN B C   1 
ATOM   3239 O O   . GLN B 1 167 ? 10.60387  -0.81237  -9.02421  1.000 41.20000  ? 285 GLN B O   1 
ATOM   3240 C CB  . GLN B 1 167 ? 12.57566  1.73948   -9.66841  1.000 39.60000  ? 285 GLN B CB  1 
ATOM   3241 C CG  . GLN B 1 167 ? 12.49743  3.12940   -10.30656 1.000 39.69000  ? 285 GLN B CG  1 
ATOM   3242 C CD  . GLN B 1 167 ? 11.23507  3.31232   -11.14403 1.000 43.56000  ? 285 GLN B CD  1 
ATOM   3243 O OE1 . GLN B 1 167 ? 10.75476  2.35725   -11.77270 1.000 43.64000  ? 285 GLN B OE1 1 
ATOM   3244 N NE2 . GLN B 1 167 ? 10.69509  4.54134   -11.16496 1.000 39.61000  ? 285 GLN B NE2 1 
ATOM   3245 N N   . LEU B 1 168 ? 12.01262  -0.46019  -7.31787  1.000 39.25000  ? 286 LEU B N   1 
ATOM   3246 C CA  . LEU B 1 168 ? 11.88877  -1.85613  -6.89163  1.000 40.67000  ? 286 LEU B CA  1 
ATOM   3247 C C   . LEU B 1 168 ? 10.44692  -2.18704  -6.52296  1.000 36.94000  ? 286 LEU B C   1 
ATOM   3248 O O   . LEU B 1 168 ? 9.93673   -3.25007  -6.88559  1.000 43.99000  ? 286 LEU B O   1 
ATOM   3249 C CB  . LEU B 1 168 ? 12.83027  -2.15800  -5.72000  1.000 37.22000  ? 286 LEU B CB  1 
ATOM   3250 C CG  . LEU B 1 168 ? 14.30408  -2.25910  -6.14363  1.000 35.58000  ? 286 LEU B CG  1 
ATOM   3251 C CD1 . LEU B 1 168 ? 15.26059  -2.30997  -4.96404  1.000 29.29000  ? 286 LEU B CD1 1 
ATOM   3252 C CD2 . LEU B 1 168 ? 14.51365  -3.45723  -7.03856  1.000 35.66000  ? 286 LEU B CD2 1 
ATOM   3253 N N   . ARG B 1 169 ? 9.75925   -1.28292  -5.83178  1.000 36.51000  ? 287 ARG B N   1 
ATOM   3254 C CA  . ARG B 1 169 ? 8.36838   -1.55984  -5.49613  1.000 32.99000  ? 287 ARG B CA  1 
ATOM   3255 C C   . ARG B 1 169 ? 7.48484   -1.51797  -6.73875  1.000 41.60000  ? 287 ARG B C   1 
ATOM   3256 O O   . ARG B 1 169 ? 6.57676   -2.34396  -6.87324  1.000 37.33000  ? 287 ARG B O   1 
ATOM   3257 C CB  . ARG B 1 169 ? 7.87287   -0.56868  -4.45705  1.000 37.45000  ? 287 ARG B CB  1 
ATOM   3258 C CG  . ARG B 1 169 ? 8.39046   -0.81051  -3.07424  1.000 36.25000  ? 287 ARG B CG  1 
ATOM   3259 C CD  . ARG B 1 169 ? 7.73492   0.11864   -2.08708  1.000 33.18000  ? 287 ARG B CD  1 
ATOM   3260 N NE  . ARG B 1 169 ? 7.89550   -0.39518  -0.73308  1.000 37.21000  ? 287 ARG B NE  1 
ATOM   3261 C CZ  . ARG B 1 169 ? 7.33199   0.12298   0.35610   1.000 39.62000  ? 287 ARG B CZ  1 
ATOM   3262 N NH1 . ARG B 1 169 ? 6.55700   1.21000   0.30629   1.000 36.90000  ? 287 ARG B NH1 1 
ATOM   3263 N NH2 . ARG B 1 169 ? 7.55048   -0.45887  1.51008   1.000 40.25000  ? 287 ARG B NH2 1 
ATOM   3264 N N   . PHE B 1 170 ? 7.74246   -0.57611  -7.66899  1.000 38.98000  ? 288 PHE B N   1 
ATOM   3265 C CA  . PHE B 1 170 ? 6.99891   -0.55425  -8.93167  1.000 34.30000  ? 288 PHE B CA  1 
ATOM   3266 C C   . PHE B 1 170 ? 7.15353   -1.84636  -9.71256  1.000 36.46000  ? 288 PHE B C   1 
ATOM   3267 O O   . PHE B 1 170 ? 6.22222   -2.26543  -10.40610 1.000 36.94000  ? 288 PHE B O   1 
ATOM   3268 C CB  . PHE B 1 170 ? 7.45356   0.59261   -9.82202  1.000 39.98000  ? 288 PHE B CB  1 
ATOM   3269 C CG  . PHE B 1 170 ? 6.79873   1.90668   -9.51391  1.000 45.59000  ? 288 PHE B CG  1 
ATOM   3270 C CD1 . PHE B 1 170 ? 5.55299   1.95579   -8.92537  1.000 39.64000  ? 288 PHE B CD1 1 
ATOM   3271 C CD2 . PHE B 1 170 ? 7.45865   3.09962   -9.78736  1.000 43.51000  ? 288 PHE B CD2 1 
ATOM   3272 C CE1 . PHE B 1 170 ? 4.97016   3.16885   -8.63128  1.000 42.45000  ? 288 PHE B CE1 1 
ATOM   3273 C CE2 . PHE B 1 170 ? 6.88282   4.30568   -9.49227  1.000 42.04000  ? 288 PHE B CE2 1 
ATOM   3274 C CZ  . PHE B 1 170 ? 5.63707   4.34079   -8.90873  1.000 42.13000  ? 288 PHE B CZ  1 
ATOM   3275 N N   . ASN B 1 171 ? 8.32354   -2.47539  -9.65099  1.000 41.77000  ? 289 ASN B N   1 
ATOM   3276 C CA  . ASN B 1 171 ? 8.50917   -3.70050  -10.41591 1.000 40.49000  ? 289 ASN B CA  1 
ATOM   3277 C C   . ASN B 1 171 ? 7.52032   -4.77141  -9.99333  1.000 35.91000  ? 289 ASN B C   1 
ATOM   3278 O O   . ASN B 1 171 ? 7.05793   -5.54151  -10.83603 1.000 38.42000  ? 289 ASN B O   1 
ATOM   3279 C CB  . ASN B 1 171 ? 9.93922   -4.21352  -10.26946 1.000 41.54000  ? 289 ASN B CB  1 
ATOM   3280 C CG  . ASN B 1 171 ? 10.27774  -5.28467  -11.28847 1.000 35.11000  ? 289 ASN B CG  1 
ATOM   3281 O OD1 . ASN B 1 171 ? 10.51186  -6.44463  -10.93742 1.000 30.93000  ? 289 ASN B OD1 1 
ATOM   3282 N ND2 . ASN B 1 171 ? 10.32620  -4.89684  -12.55754 1.000 31.54000  ? 289 ASN B ND2 1 
ATOM   3283 N N   . THR B 1 172 ? 7.14788   -4.80923  -8.71116  1.000 33.55000  ? 290 THR B N   1 
ATOM   3284 C CA  . THR B 1 172 ? 6.32006   -5.90714  -8.22066  1.000 37.40000  ? 290 THR B CA  1 
ATOM   3285 C C   . THR B 1 172 ? 4.87285   -5.80416  -8.70204  1.000 46.13000  ? 290 THR B C   1 
ATOM   3286 O O   . THR B 1 172 ? 4.10989   -6.77511  -8.54658  1.000 41.34000  ? 290 THR B O   1 
ATOM   3287 C CB  . THR B 1 172 ? 6.34773   -5.96193  -6.67866  1.000 40.21000  ? 290 THR B CB  1 
ATOM   3288 O OG1 . THR B 1 172 ? 5.93001   -4.70485  -6.13265  1.000 42.27000  ? 290 THR B OG1 1 
ATOM   3289 C CG2 . THR B 1 172 ? 7.75795   -6.27090  -6.15324  1.000 32.79000  ? 290 THR B CG2 1 
ATOM   3290 N N   . VAL B 1 173 ? 4.47865   -4.64322  -9.24202  1.000 37.11000  ? 291 VAL B N   1 
ATOM   3291 C CA  . VAL B 1 173 ? 3.16740   -4.41526  -9.84248  1.000 34.17000  ? 291 VAL B CA  1 
ATOM   3292 C C   . VAL B 1 173 ? 3.25974   -4.30746  -11.35353 1.000 38.13000  ? 291 VAL B C   1 
ATOM   3293 O O   . VAL B 1 173 ? 2.24146   -4.10352  -12.01612 1.000 40.79000  ? 291 VAL B O   1 
ATOM   3294 C CB  . VAL B 1 173 ? 2.48269   -3.15416  -9.26135  1.000 45.25000  ? 291 VAL B CB  1 
ATOM   3295 C CG1 . VAL B 1 173 ? 2.17033   -3.30895  -7.78319  1.000 39.12000  ? 291 VAL B CG1 1 
ATOM   3296 C CG2 . VAL B 1 173 ? 3.32164   -1.89121  -9.46688  1.000 38.95000  ? 291 VAL B CG2 1 
ATOM   3297 N N   . PHE B 1 174 ? 4.45749   -4.41457  -11.91304 1.000 39.71000  ? 292 PHE B N   1 
ATOM   3298 C CA  . PHE B 1 174 ? 4.63886   -4.39277  -13.35813 1.000 45.41000  ? 292 PHE B CA  1 
ATOM   3299 C C   . PHE B 1 174 ? 4.18855   -5.70684  -13.97675 1.000 47.14000  ? 292 PHE B C   1 
ATOM   3300 O O   . PHE B 1 174 ? 4.46775   -6.78878  -13.45773 1.000 40.08000  ? 292 PHE B O   1 
ATOM   3301 C CB  . PHE B 1 174 ? 6.11272   -4.15086  -13.70380 1.000 44.91000  ? 292 PHE B CB  1 
ATOM   3302 C CG  . PHE B 1 174 ? 6.38808   -4.00007  -15.18094 1.000 42.70000  ? 292 PHE B CG  1 
ATOM   3303 C CD1 . PHE B 1 174 ? 5.79979   -2.98015  -15.91782 1.000 45.43000  ? 292 PHE B CD1 1 
ATOM   3304 C CD2 . PHE B 1 174 ? 7.27078   -4.84918  -15.82021 1.000 41.40000  ? 292 PHE B CD2 1 
ATOM   3305 C CE1 . PHE B 1 174 ? 6.08020   -2.81534  -17.27297 1.000 42.51000  ? 292 PHE B CE1 1 
ATOM   3306 C CE2 . PHE B 1 174 ? 7.54519   -4.70137  -17.16635 1.000 45.70000  ? 292 PHE B CE2 1 
ATOM   3307 C CZ  . PHE B 1 174 ? 6.94791   -3.67845  -17.89523 1.000 46.97000  ? 292 PHE B CZ  1 
ATOM   3308 N N   . ASN B 1 175 ? 3.51506   -5.60197  -15.10547 1.000 49.49000  ? 293 ASN B N   1 
ATOM   3309 C CA  . ASN B 1 175 ? 3.02770   -6.74306  -15.86111 1.000 44.51000  ? 293 ASN B CA  1 
ATOM   3310 C C   . ASN B 1 175 ? 3.80713   -6.75126  -17.17245 1.000 50.53000  ? 293 ASN B C   1 
ATOM   3311 O O   . ASN B 1 175 ? 3.58578   -5.89136  -18.03147 1.000 54.18000  ? 293 ASN B O   1 
ATOM   3312 C CB  . ASN B 1 175 ? 1.52361   -6.60704  -16.07747 1.000 51.53000  ? 293 ASN B CB  1 
ATOM   3313 C CG  . ASN B 1 175 ? 0.92724   -7.76113  -16.84006 1.000 50.41000  ? 293 ASN B CG  1 
ATOM   3314 O OD1 . ASN B 1 175 ? 1.52181   -8.26127  -17.79225 1.000 52.33000  ? 293 ASN B OD1 1 
ATOM   3315 N ND2 . ASN B 1 175 ? -0.27460  -8.17804  -16.43948 1.000 47.29000  ? 293 ASN B ND2 1 
ATOM   3316 N N   . ALA B 1 176 ? 4.73003   -7.70731  -17.32472 1.000 49.73000  ? 294 ALA B N   1 
ATOM   3317 C CA  . ALA B 1 176 ? 5.59552   -7.69749  -18.50010 1.000 52.19000  ? 294 ALA B CA  1 
ATOM   3318 C C   . ALA B 1 176 ? 4.82996   -8.06463  -19.76672 1.000 55.63000  ? 294 ALA B C   1 
ATOM   3319 O O   . ALA B 1 176 ? 5.15150   -7.56279  -20.85093 1.000 59.90000  ? 294 ALA B O   1 
ATOM   3320 C CB  . ALA B 1 176 ? 6.77958   -8.64350  -18.30449 1.000 39.59000  ? 294 ALA B CB  1 
ATOM   3321 N N   . GLU B 1 177 ? 3.81398   -8.92159  -19.65116 1.000 54.49000  ? 295 GLU B N   1 
ATOM   3322 C CA  . GLU B 1 177 ? 3.05645   -9.32672  -20.82978 1.000 60.01000  ? 295 GLU B CA  1 
ATOM   3323 C C   . GLU B 1 177 ? 2.36520   -8.13779  -21.49163 1.000 58.34000  ? 295 GLU B C   1 
ATOM   3324 O O   . GLU B 1 177 ? 2.23766   -8.10495  -22.72158 1.000 66.41000  ? 295 GLU B O   1 
ATOM   3325 C CB  . GLU B 1 177 ? 2.04258   -10.40864 -20.45119 1.000 59.28000  ? 295 GLU B CB  1 
ATOM   3326 N N   . THR B 1 178 ? 1.95557   -7.13567  -20.71059 1.000 53.61000  ? 296 THR B N   1 
ATOM   3327 C CA  . THR B 1 178 ? 1.19838   -5.99972  -21.22641 1.000 50.92000  ? 296 THR B CA  1 
ATOM   3328 C C   . THR B 1 178 ? 1.89849   -4.64572  -21.07690 1.000 51.21000  ? 296 THR B C   1 
ATOM   3329 O O   . THR B 1 178 ? 1.29637   -3.61875  -21.41677 1.000 46.84000  ? 296 THR B O   1 
ATOM   3330 C CB  . THR B 1 178 ? -0.18232  -5.92359  -20.54082 1.000 49.30000  ? 296 THR B CB  1 
ATOM   3331 O OG1 . THR B 1 178 ? -0.01870  -5.57741  -19.15893 1.000 58.01000  ? 296 THR B OG1 1 
ATOM   3332 C CG2 . THR B 1 178 ? -0.91039  -7.25257  -20.60832 1.000 41.01000  ? 296 THR B CG2 1 
ATOM   3333 N N   . GLY B 1 179 ? 3.13171   -4.60269  -20.57444 1.000 49.81000  ? 297 GLY B N   1 
ATOM   3334 C CA  . GLY B 1 179 ? 3.83882   -3.33569  -20.40092 1.000 43.92000  ? 297 GLY B CA  1 
ATOM   3335 C C   . GLY B 1 179 ? 3.11324   -2.34655  -19.51473 1.000 49.17000  ? 297 GLY B C   1 
ATOM   3336 O O   . GLY B 1 179 ? 3.05814   -1.14859  -19.83087 1.000 49.16000  ? 297 GLY B O   1 
ATOM   3337 N N   . THR B 1 180 ? 2.56571   -2.82338  -18.39743 1.000 42.35000  ? 298 THR B N   1 
ATOM   3338 C CA  . THR B 1 180 ? 1.63609   -2.07024  -17.57513 1.000 39.41000  ? 298 THR B CA  1 
ATOM   3339 C C   . THR B 1 180 ? 2.01073   -2.20106  -16.10427 1.000 45.72000  ? 298 THR B C   1 
ATOM   3340 O O   . THR B 1 180 ? 2.28291   -3.30300  -15.61524 1.000 43.43000  ? 298 THR B O   1 
ATOM   3341 C CB  . THR B 1 180 ? 0.19999   -2.56523  -17.78043 1.000 40.56000  ? 298 THR B CB  1 
ATOM   3342 O OG1 . THR B 1 180 ? -0.13261  -2.49440  -19.16630 1.000 37.36000  ? 298 THR B OG1 1 
ATOM   3343 C CG2 . THR B 1 180 ? -0.80462  -1.73309  -16.94111 1.000 41.42000  ? 298 THR B CG2 1 
ATOM   3344 N N   . TRP B 1 181 ? 2.01307   -1.07597  -15.40342 1.000 44.29000  ? 299 TRP B N   1 
ATOM   3345 C CA  . TRP B 1 181 ? 2.12070   -1.06178  -13.95647 1.000 44.34000  ? 299 TRP B CA  1 
ATOM   3346 C C   . TRP B 1 181 ? 0.70595   -1.01366  -13.38686 1.000 40.95000  ? 299 TRP B C   1 
ATOM   3347 O O   . TRP B 1 181 ? 0.05598   0.03136   -13.40372 1.000 50.36000  ? 299 TRP B O   1 
ATOM   3348 C CB  . TRP B 1 181 ? 2.96394   0.12826   -13.50400 1.000 40.75000  ? 299 TRP B CB  1 
ATOM   3349 C CG  . TRP B 1 181 ? 4.41978   -0.00083  -13.85462 1.000 38.87000  ? 299 TRP B CG  1 
ATOM   3350 C CD1 . TRP B 1 181 ? 5.39909   -0.59676  -13.10296 1.000 44.26000  ? 299 TRP B CD1 1 
ATOM   3351 C CD2 . TRP B 1 181 ? 5.06328   0.47199   -15.04196 1.000 36.88000  ? 299 TRP B CD2 1 
ATOM   3352 N NE1 . TRP B 1 181 ? 6.61981   -0.52389  -13.75751 1.000 40.71000  ? 299 TRP B NE1 1 
ATOM   3353 C CE2 . TRP B 1 181 ? 6.43731   0.13496   -14.94452 1.000 40.55000  ? 299 TRP B CE2 1 
ATOM   3354 C CE3 . TRP B 1 181 ? 4.61480   1.14185   -16.18285 1.000 38.74000  ? 299 TRP B CE3 1 
ATOM   3355 C CZ2 . TRP B 1 181 ? 7.35788   0.44380   -15.94596 1.000 43.20000  ? 299 TRP B CZ2 1 
ATOM   3356 C CZ3 . TRP B 1 181 ? 5.53637   1.45869   -17.17930 1.000 42.23000  ? 299 TRP B CZ3 1 
ATOM   3357 C CH2 . TRP B 1 181 ? 6.89342   1.10667   -17.05185 1.000 47.59000  ? 299 TRP B CH2 1 
ATOM   3358 N N   . GLU B 1 182 ? 0.22414   -2.14058  -12.89250 1.000 39.36000  ? 300 GLU B N   1 
ATOM   3359 C CA  . GLU B 1 182 ? -1.11461  -2.22546  -12.31190 1.000 45.38000  ? 300 GLU B CA  1 
ATOM   3360 C C   . GLU B 1 182 ? -1.06397  -1.74027  -10.86699 1.000 44.54000  ? 300 GLU B C   1 
ATOM   3361 O O   . GLU B 1 182 ? -0.76259  -2.49415  -9.94702  1.000 44.82000  ? 300 GLU B O   1 
ATOM   3362 C CB  . GLU B 1 182 ? -1.63371  -3.64946  -12.43549 1.000 44.76000  ? 300 GLU B CB  1 
ATOM   3363 C CG  . GLU B 1 182 ? -1.43435  -4.18366  -13.86050 1.000 49.92000  ? 300 GLU B CG  1 
ATOM   3364 C CD  . GLU B 1 182 ? -1.86747  -5.62166  -14.02912 1.000 68.96000  ? 300 GLU B CD  1 
ATOM   3365 O OE1 . GLU B 1 182 ? -2.14604  -6.27252  -12.99591 1.000 81.45000  ? 300 GLU B OE1 1 
ATOM   3366 O OE2 . GLU B 1 182 ? -1.91499  -6.10382  -15.18704 1.000 65.55000  ? 300 GLU B OE2 1 
ATOM   3367 N N   . CYS B 1 183 ? -1.37484  -0.45523  -10.67103 1.000 46.66000  ? 301 CYS B N   1 
ATOM   3368 C CA  . CYS B 1 183 ? -1.34925  0.17694   -9.35512  1.000 41.77000  ? 301 CYS B CA  1 
ATOM   3369 C C   . CYS B 1 183 ? -2.76100  0.32406   -8.78452  1.000 42.94000  ? 301 CYS B C   1 
ATOM   3370 O O   . CYS B 1 183 ? -3.27488  1.42210   -8.59445  1.000 50.63000  ? 301 CYS B O   1 
ATOM   3371 C CB  . CYS B 1 183 ? -0.67424  1.54191   -9.43660  1.000 42.34000  ? 301 CYS B CB  1 
ATOM   3372 S SG  . CYS B 1 183 ? 0.97547   1.57678   -10.09132 1.000 39.83000  ? 301 CYS B SG  1 
ATOM   3373 N N   . GLY B 1 184 ? -3.37188  -0.79287  -8.44711  1.000 45.29000  ? 302 GLY B N   1 
ATOM   3374 C CA  . GLY B 1 184 ? -4.67260  -0.69075  -7.80455  1.000 45.37000  ? 302 GLY B CA  1 
ATOM   3375 C C   . GLY B 1 184 ? -5.67202  -0.17785  -8.80819  1.000 48.90000  ? 302 GLY B C   1 
ATOM   3376 O O   . GLY B 1 184 ? -5.75553  -0.69000  -9.92708  1.000 53.05000  ? 302 GLY B O   1 
ATOM   3377 N N   . ARG B 1 185 ? -6.41083  0.87522   -8.44101  1.000 52.64000  ? 303 ARG B N   1 
ATOM   3378 C CA  . ARG B 1 185 ? -7.40721  1.42613   -9.35764  1.000 53.66000  ? 303 ARG B CA  1 
ATOM   3379 C C   . ARG B 1 185 ? -6.77872  2.12695   -10.56601 1.000 53.12000  ? 303 ARG B C   1 
ATOM   3380 O O   . ARG B 1 185 ? -7.45816  2.29383   -11.58174 1.000 55.49000  ? 303 ARG B O   1 
ATOM   3381 C CB  . ARG B 1 185 ? -8.34486  2.38526   -8.60936  1.000 50.90000  ? 303 ARG B CB  1 
ATOM   3382 N N   . LEU B 1 186 ? -5.50268  2.51192   -10.49562 1.000 49.35000  ? 304 LEU B N   1 
ATOM   3383 C CA  . LEU B 1 186 ? -4.80014  3.16575   -11.59701 1.000 48.02000  ? 304 LEU B CA  1 
ATOM   3384 C C   . LEU B 1 186 ? -3.96052  2.17062   -12.39325 1.000 48.31000  ? 304 LEU B C   1 
ATOM   3385 O O   . LEU B 1 186 ? -3.47831  1.17267   -11.85433 1.000 52.25000  ? 304 LEU B O   1 
ATOM   3386 C CB  . LEU B 1 186 ? -3.89287  4.27379   -11.06856 1.000 42.78000  ? 304 LEU B CB  1 
ATOM   3387 C CG  . LEU B 1 186 ? -4.60147  5.33493   -10.22639 1.000 54.95000  ? 304 LEU B CG  1 
ATOM   3388 C CD1 . LEU B 1 186 ? -4.54583  4.99612   -8.73337  1.000 50.71000  ? 304 LEU B CD1 1 
ATOM   3389 C CD2 . LEU B 1 186 ? -3.96654  6.66887   -10.46885 1.000 48.73000  ? 304 LEU B CD2 1 
ATOM   3390 N N   . SER B 1 187 ? -3.77507  2.45644   -13.68637 1.000 46.87000  ? 305 SER B N   1 
ATOM   3391 C CA  . SER B 1 187 ? -2.90847  1.65230   -14.54264 1.000 41.50000  ? 305 SER B CA  1 
ATOM   3392 C C   . SER B 1 187 ? -2.09783  2.57415   -15.44112 1.000 48.08000  ? 305 SER B C   1 
ATOM   3393 O O   . SER B 1 187 ? -2.61401  3.59311   -15.91503 1.000 42.23000  ? 305 SER B O   1 
ATOM   3394 C CB  . SER B 1 187 ? -3.70788  0.67721   -15.41316 1.000 48.21000  ? 305 SER B CB  1 
ATOM   3395 O OG  . SER B 1 187 ? -4.36257  -0.29967  -14.62874 1.000 56.96000  ? 305 SER B OG  1 
ATOM   3396 N N   . TYR B 1 188 ? -0.82895  2.20908   -15.67962 1.000 51.67000  ? 306 TYR B N   1 
ATOM   3397 C CA  . TYR B 1 188 ? 0.07068   2.94594   -16.57311 1.000 47.73000  ? 306 TYR B CA  1 
ATOM   3398 C C   . TYR B 1 188 ? 0.54417   2.00677   -17.67619 1.000 46.32000  ? 306 TYR B C   1 
ATOM   3399 O O   . TYR B 1 188 ? 1.25926   1.04179   -17.40038 1.000 47.08000  ? 306 TYR B O   1 
ATOM   3400 C CB  . TYR B 1 188 ? 1.25204   3.53300   -15.79971 1.000 42.39000  ? 306 TYR B CB  1 
ATOM   3401 C CG  . TYR B 1 188 ? 0.80257   4.40917   -14.64463 1.000 45.04000  ? 306 TYR B CG  1 
ATOM   3402 C CD1 . TYR B 1 188 ? 0.52209   3.85635   -13.40743 1.000 45.69000  ? 306 TYR B CD1 1 
ATOM   3403 C CD2 . TYR B 1 188 ? 0.61454   5.78416   -14.80473 1.000 41.43000  ? 306 TYR B CD2 1 
ATOM   3404 C CE1 . TYR B 1 188 ? 0.09058   4.63850   -12.34735 1.000 42.46000  ? 306 TYR B CE1 1 
ATOM   3405 C CE2 . TYR B 1 188 ? 0.18203   6.57131   -13.75264 1.000 41.13000  ? 306 TYR B CE2 1 
ATOM   3406 C CZ  . TYR B 1 188 ? -0.07746  5.98248   -12.52245 1.000 44.55000  ? 306 TYR B CZ  1 
ATOM   3407 O OH  . TYR B 1 188 ? -0.51096  6.71464   -11.44636 1.000 44.18000  ? 306 TYR B OH  1 
ATOM   3408 N N   . CYS B 1 189 ? 0.14864   2.28662   -18.92006 1.000 52.95000  ? 307 CYS B N   1 
ATOM   3409 C CA  . CYS B 1 189 ? 0.42111   1.41546   -20.06306 1.000 52.82000  ? 307 CYS B CA  1 
ATOM   3410 C C   . CYS B 1 189 ? 1.53577   2.03732   -20.88863 1.000 48.86000  ? 307 CYS B C   1 
ATOM   3411 O O   . CYS B 1 189 ? 1.45266   3.21527   -21.23575 1.000 54.06000  ? 307 CYS B O   1 
ATOM   3412 C CB  . CYS B 1 189 ? -0.82228  1.26638   -20.94450 1.000 52.45000  ? 307 CYS B CB  1 
ATOM   3413 S SG  . CYS B 1 189 ? -2.31792  0.68654   -20.09577 1.000 77.39000  ? 307 CYS B SG  1 
ATOM   3414 N N   . LEU B 1 190 ? 2.56060   1.25624   -21.21997 1.000 50.74000  ? 308 LEU B N   1 
ATOM   3415 C CA  . LEU B 1 190 ? 3.61023   1.75509   -22.11150 1.000 56.57000  ? 308 LEU B CA  1 
ATOM   3416 C C   . LEU B 1 190 ? 3.05064   2.11792   -23.49430 1.000 66.46000  ? 308 LEU B C   1 
ATOM   3417 O O   . LEU B 1 190 ? 2.31834   1.33086   -24.11588 1.000 64.18000  ? 308 LEU B O   1 
ATOM   3418 C CB  . LEU B 1 190 ? 4.71514   0.71304   -22.24984 1.000 52.47000  ? 308 LEU B CB  1 
ATOM   3419 C CG  . LEU B 1 190 ? 5.68565   0.69017   -21.07126 1.000 58.94000  ? 308 LEU B CG  1 
ATOM   3420 C CD1 . LEU B 1 190 ? 6.66756   -0.49188  -21.19953 1.000 49.65000  ? 308 LEU B CD1 1 
ATOM   3421 C CD2 . LEU B 1 190 ? 6.40378   2.03917   -20.88076 1.000 44.08000  ? 308 LEU B CD2 1 
ATOM   3422 N N   . GLU B 1 191 ? 3.41946   3.31585   -23.97962 1.000 65.63000  ? 309 GLU B N   1 
ATOM   3423 C CA  . GLU B 1 191 ? 2.90293   3.86769   -25.23147 1.000 70.25000  ? 309 GLU B CA  1 
ATOM   3424 C C   . GLU B 1 191 ? 3.10340   2.89053   -26.38243 1.000 79.50000  ? 309 GLU B C   1 
ATOM   3425 O O   . GLU B 1 191 ? 4.24322   2.59845   -26.77889 1.000 69.10000  ? 309 GLU B O   1 
ATOM   3426 C CB  . GLU B 1 191 ? 3.55983   5.21363   -25.55094 1.000 67.14000  ? 309 GLU B CB  1 
ATOM   3427 N N   . ASP B 1 192 ? 1.98115   2.39050   -26.90887 1.000 85.02000  ? 310 ASP B N   1 
ATOM   3428 C CA  . ASP B 1 192 ? 1.93972   1.25338   -27.82670 1.000 89.17000  ? 310 ASP B CA  1 
ATOM   3429 C C   . ASP B 1 192 ? 2.41611   1.61117   -29.23896 1.000 79.83000  ? 310 ASP B C   1 
ATOM   3430 O O   . ASP B 1 192 ? 3.05880   0.79806   -29.91013 1.000 72.88000  ? 310 ASP B O   1 
ATOM   3431 C CB  . ASP B 1 192 ? 0.51368   0.68241   -27.87400 1.000 73.39000  ? 310 ASP B CB  1 
ATOM   3432 N N   . GLY B 1 196 ? 9.70478   -2.08342  -32.02865 1.000 101.90000 ? 314 GLY B N   1 
ATOM   3433 C CA  . GLY B 1 196 ? 8.70424   -2.09425  -30.97321 1.000 102.82000 ? 314 GLY B CA  1 
ATOM   3434 C C   . GLY B 1 196 ? 9.27985   -2.29708  -29.58143 1.000 99.69000  ? 314 GLY B C   1 
ATOM   3435 O O   . GLY B 1 196 ? 9.48120   -1.32999  -28.84665 1.000 97.08000  ? 314 GLY B O   1 
ATOM   3436 N N   . PHE B 1 197 ? 9.53897   -3.55904  -29.21338 1.000 103.35000 ? 315 PHE B N   1 
ATOM   3437 C CA  . PHE B 1 197 ? 10.18352  -3.84189  -27.93262 1.000 100.21000 ? 315 PHE B CA  1 
ATOM   3438 C C   . PHE B 1 197 ? 11.69849  -3.68594  -28.01330 1.000 97.45000  ? 315 PHE B C   1 
ATOM   3439 O O   . PHE B 1 197 ? 12.33394  -3.35983  -27.00262 1.000 95.93000  ? 315 PHE B O   1 
ATOM   3440 C CB  . PHE B 1 197 ? 9.82169   -5.24681  -27.43528 1.000 83.23000  ? 315 PHE B CB  1 
ATOM   3441 N N   . GLN B 1 198 ? 12.29297  -3.90312  -29.19353 1.000 96.39000  ? 316 GLN B N   1 
ATOM   3442 C CA  . GLN B 1 198 ? 13.71490  -3.61119  -29.36119 1.000 102.39000 ? 316 GLN B CA  1 
ATOM   3443 C C   . GLN B 1 198 ? 14.01305  -2.13016  -29.12552 1.000 97.55000  ? 316 GLN B C   1 
ATOM   3444 O O   . GLN B 1 198 ? 15.09628  -1.78413  -28.63304 1.000 92.05000  ? 316 GLN B O   1 
ATOM   3445 C CB  . GLN B 1 198 ? 14.18428  -4.04439  -30.75334 1.000 88.15000  ? 316 GLN B CB  1 
ATOM   3446 N N   . GLN B 1 199 ? 13.06093  -1.24818  -29.45622 1.000 95.93000  ? 317 GLN B N   1 
ATOM   3447 C CA  . GLN B 1 199 ? 13.20909  0.17985   -29.19048 1.000 96.24000  ? 317 GLN B CA  1 
ATOM   3448 C C   . GLN B 1 199 ? 13.00275  0.49506   -27.70943 1.000 97.51000  ? 317 GLN B C   1 
ATOM   3449 O O   . GLN B 1 199 ? 13.79604  1.23011   -27.10388 1.000 88.11000  ? 317 GLN B O   1 
ATOM   3450 C CB  . GLN B 1 199 ? 12.22274  0.97677   -30.05316 1.000 88.39000  ? 317 GLN B CB  1 
ATOM   3451 N N   . LEU B 1 200 ? 11.93499  -0.05083  -27.11289 1.000 97.38000  ? 318 LEU B N   1 
ATOM   3452 C CA  . LEU B 1 200 ? 11.66662  0.18837   -25.69681 1.000 89.33000  ? 318 LEU B CA  1 
ATOM   3453 C C   . LEU B 1 200 ? 12.77998  -0.37555  -24.82122 1.000 83.77000  ? 318 LEU B C   1 
ATOM   3454 O O   . LEU B 1 200 ? 13.17044  0.24357   -23.82447 1.000 80.22000  ? 318 LEU B O   1 
ATOM   3455 C CB  . LEU B 1 200 ? 10.31177  -0.41454  -25.30714 1.000 89.57000  ? 318 LEU B CB  1 
ATOM   3456 N N   . LEU B 1 201 ? 13.31679  -1.54162  -25.18330 1.000 83.76000  ? 319 LEU B N   1 
ATOM   3457 C CA  . LEU B 1 201 ? 14.41710  -2.11855  -24.42370 1.000 78.97000  ? 319 LEU B CA  1 
ATOM   3458 C C   . LEU B 1 201 ? 15.71507  -1.32961  -24.56337 1.000 80.01000  ? 319 LEU B C   1 
ATOM   3459 O O   . LEU B 1 201 ? 16.70134  -1.69255  -23.91075 1.000 80.38000  ? 319 LEU B O   1 
ATOM   3460 C CB  . LEU B 1 201 ? 14.64587  -3.57261  -24.84761 1.000 83.93000  ? 319 LEU B CB  1 
ATOM   3461 N N   . LEU B 1 202 ? 15.75273  -0.28772  -25.40053 1.000 78.56000  ? 320 LEU B N   1 
ATOM   3462 C CA  . LEU B 1 202 ? 16.89675  0.61724   -25.42815 1.000 75.72000  ? 320 LEU B CA  1 
ATOM   3463 C C   . LEU B 1 202 ? 16.89429  1.58640   -24.25628 1.000 72.19000  ? 320 LEU B C   1 
ATOM   3464 O O   . LEU B 1 202 ? 17.95146  2.12341   -23.90681 1.000 77.29000  ? 320 LEU B O   1 
ATOM   3465 C CB  . LEU B 1 202 ? 16.92920  1.40907   -26.73827 1.000 80.43000  ? 320 LEU B CB  1 
ATOM   3466 C CG  . LEU B 1 202 ? 17.63466  0.76189   -27.93249 1.000 83.43000  ? 320 LEU B CG  1 
ATOM   3467 C CD1 . LEU B 1 202 ? 17.28611  1.48472   -29.23543 1.000 78.07000  ? 320 LEU B CD1 1 
ATOM   3468 C CD2 . LEU B 1 202 ? 19.13876  0.75187   -27.70214 1.000 73.32000  ? 320 LEU B CD2 1 
ATOM   3469 N N   . GLU B 1 203 ? 15.73656  1.82452   -23.65080 1.000 65.63000  ? 321 GLU B N   1 
ATOM   3470 C CA  . GLU B 1 203 ? 15.60610  2.67368   -22.47586 1.000 56.84000  ? 321 GLU B CA  1 
ATOM   3471 C C   . GLU B 1 203 ? 16.02062  1.87583   -21.23793 1.000 52.80000  ? 321 GLU B C   1 
ATOM   3472 O O   . GLU B 1 203 ? 15.35374  0.89590   -20.89251 1.000 52.86000  ? 321 GLU B O   1 
ATOM   3473 C CB  . GLU B 1 203 ? 14.16615  3.16673   -22.39930 1.000 55.90000  ? 321 GLU B CB  1 
ATOM   3474 C CG  . GLU B 1 203 ? 13.88161  4.26987   -21.41532 1.000 61.01000  ? 321 GLU B CG  1 
ATOM   3475 C CD  . GLU B 1 203 ? 14.87263  5.41184   -21.44890 1.000 63.50000  ? 321 GLU B CD  1 
ATOM   3476 O OE1 . GLU B 1 203 ? 14.70730  6.33273   -22.27296 1.000 69.12000  ? 321 GLU B OE1 1 
ATOM   3477 O OE2 . GLU B 1 203 ? 15.80000  5.40892   -20.61631 1.000 67.38000  ? 321 GLU B OE2 1 
ATOM   3478 N N   . PRO B 1 204 ? 17.12092  2.23789   -20.56346 1.000 51.39000  ? 322 PRO B N   1 
ATOM   3479 C CA  . PRO B 1 204 ? 17.66835  1.35101   -19.51658 1.000 53.74000  ? 322 PRO B CA  1 
ATOM   3480 C C   . PRO B 1 204 ? 16.69583  0.99819   -18.39811 1.000 49.01000  ? 322 PRO B C   1 
ATOM   3481 O O   . PRO B 1 204 ? 16.73502  -0.13275  -17.89298 1.000 48.36000  ? 322 PRO B O   1 
ATOM   3482 C CB  . PRO B 1 204 ? 18.85861  2.16005   -18.97221 1.000 49.48000  ? 322 PRO B CB  1 
ATOM   3483 C CG  . PRO B 1 204 ? 19.29915  2.97488   -20.08651 1.000 41.46000  ? 322 PRO B CG  1 
ATOM   3484 C CD  . PRO B 1 204 ? 18.03583  3.35582   -20.84101 1.000 57.65000  ? 322 PRO B CD  1 
ATOM   3485 N N   . MET B 1 205 ? 15.84504  1.93627   -17.97386 1.000 46.03000  ? 323 MET B N   1 
ATOM   3486 C CA  . MET B 1 205 ? 14.89950  1.63844   -16.90641 1.000 37.85000  ? 323 MET B CA  1 
ATOM   3487 C C   . MET B 1 205 ? 13.81827  0.67341   -17.36781 1.000 44.67000  ? 323 MET B C   1 
ATOM   3488 O O   . MET B 1 205 ? 13.32859  -0.13247  -16.56949 1.000 44.89000  ? 323 MET B O   1 
ATOM   3489 C CB  . MET B 1 205 ? 14.26777  2.92353   -16.37831 1.000 51.94000  ? 323 MET B CB  1 
ATOM   3490 C CG  . MET B 1 205 ? 13.55135  2.75973   -15.04297 1.000 50.02000  ? 323 MET B CG  1 
ATOM   3491 S SD  . MET B 1 205 ? 14.71892  2.31487   -13.70942 1.000 60.82000  ? 323 MET B SD  1 
ATOM   3492 C CE  . MET B 1 205 ? 14.07411  0.76997   -13.16893 1.000 44.14000  ? 323 MET B CE  1 
ATOM   3493 N N   . LEU B 1 206 ? 13.39672  0.75526   -18.63864 1.000 47.86000  ? 324 LEU B N   1 
ATOM   3494 C CA  . LEU B 1 206 ? 12.44647  -0.23378  -19.13909 1.000 41.33000  ? 324 LEU B CA  1 
ATOM   3495 C C   . LEU B 1 206 ? 13.09438  -1.60281  -19.23819 1.000 43.53000  ? 324 LEU B C   1 
ATOM   3496 O O   . LEU B 1 206 ? 12.48652  -2.61075  -18.86479 1.000 47.65000  ? 324 LEU B O   1 
ATOM   3497 C CB  . LEU B 1 206 ? 11.89489  0.17105   -20.49790 1.000 51.02000  ? 324 LEU B CB  1 
ATOM   3498 C CG  . LEU B 1 206 ? 11.07289  1.44707   -20.58572 1.000 56.10000  ? 324 LEU B CG  1 
ATOM   3499 C CD1 . LEU B 1 206 ? 10.36530  1.47091   -21.92841 1.000 62.10000  ? 324 LEU B CD1 1 
ATOM   3500 C CD2 . LEU B 1 206 ? 10.08839  1.53825   -19.43530 1.000 53.63000  ? 324 LEU B CD2 1 
ATOM   3501 N N   . LYS B 1 207 ? 14.32416  -1.66392  -19.74872 1.000 42.97000  ? 325 LYS B N   1 
ATOM   3502 C CA  . LYS B 1 207 ? 15.05011  -2.92994  -19.76187 1.000 49.27000  ? 325 LYS B CA  1 
ATOM   3503 C C   . LYS B 1 207 ? 15.17072  -3.49176  -18.34384 1.000 45.87000  ? 325 LYS B C   1 
ATOM   3504 O O   . LYS B 1 207 ? 14.91678  -4.68272  -18.11057 1.000 46.79000  ? 325 LYS B O   1 
ATOM   3505 C CB  . LYS B 1 207 ? 16.42083  -2.72507  -20.42749 1.000 49.87000  ? 325 LYS B CB  1 
ATOM   3506 C CG  . LYS B 1 207 ? 17.35279  -3.91610  -20.43874 1.000 51.02000  ? 325 LYS B CG  1 
ATOM   3507 N N   . PHE B 1 208 ? 15.51417  -2.63364  -17.37411 1.000 39.45000  ? 326 PHE B N   1 
ATOM   3508 C CA  . PHE B 1 208 ? 15.64476  -3.08646  -15.98711 1.000 38.54000  ? 326 PHE B CA  1 
ATOM   3509 C C   . PHE B 1 208 ? 14.35695  -3.74535  -15.50346 1.000 41.63000  ? 326 PHE B C   1 
ATOM   3510 O O   . PHE B 1 208 ? 14.37716  -4.85228  -14.95232 1.000 43.26000  ? 326 PHE B O   1 
ATOM   3511 C CB  . PHE B 1 208 ? 16.03018  -1.90535  -15.09843 1.000 36.23000  ? 326 PHE B CB  1 
ATOM   3512 C CG  . PHE B 1 208 ? 16.33979  -2.26717  -13.67452 1.000 36.70000  ? 326 PHE B CG  1 
ATOM   3513 C CD1 . PHE B 1 208 ? 15.32721  -2.33501  -12.71807 1.000 37.92000  ? 326 PHE B CD1 1 
ATOM   3514 C CD2 . PHE B 1 208 ? 17.65396  -2.50416  -13.27506 1.000 41.13000  ? 326 PHE B CD2 1 
ATOM   3515 C CE1 . PHE B 1 208 ? 15.60878  -2.67284  -11.38914 1.000 43.57000  ? 326 PHE B CE1 1 
ATOM   3516 C CE2 . PHE B 1 208 ? 17.95553  -2.84499  -11.94515 1.000 43.44000  ? 326 PHE B CE2 1 
ATOM   3517 C CZ  . PHE B 1 208 ? 16.93294  -2.93783  -11.00269 1.000 45.98000  ? 326 PHE B CZ  1 
ATOM   3518 N N   . HIS B 1 209 ? 13.21986  -3.09735  -15.74305 1.000 37.47000  ? 327 HIS B N   1 
ATOM   3519 C CA  . HIS B 1 209 ? 11.94604  -3.64925  -15.30642 1.000 36.16000  ? 327 HIS B CA  1 
ATOM   3520 C C   . HIS B 1 209 ? 11.65670  -4.98134  -15.98611 1.000 42.89000  ? 327 HIS B C   1 
ATOM   3521 O O   . HIS B 1 209 ? 11.16595  -5.92224  -15.34577 1.000 42.31000  ? 327 HIS B O   1 
ATOM   3522 C CB  . HIS B 1 209 ? 10.81795  -2.64626  -15.57906 1.000 40.19000  ? 327 HIS B CB  1 
ATOM   3523 C CG  . HIS B 1 209 ? 10.65645  -1.62411  -14.49412 1.000 43.35000  ? 327 HIS B CG  1 
ATOM   3524 N ND1 . HIS B 1 209 ? 10.18599  -1.93892  -13.23288 1.000 41.00000  ? 327 HIS B ND1 1 
ATOM   3525 C CD2 . HIS B 1 209 ? 10.91550  -0.29411  -14.47641 1.000 41.05000  ? 327 HIS B CD2 1 
ATOM   3526 C CE1 . HIS B 1 209 ? 10.16035  -0.84882  -12.48901 1.000 43.62000  ? 327 HIS B CE1 1 
ATOM   3527 N NE2 . HIS B 1 209 ? 10.60307  0.16307   -13.21634 1.000 44.81000  ? 327 HIS B NE2 1 
ATOM   3528 N N   . TYR B 1 210 ? 11.94113  -5.08652  -17.28422 1.000 43.04000  ? 328 TYR B N   1 
ATOM   3529 C CA  . TYR B 1 210 ? 11.73680  -6.36560  -17.95496 1.000 43.01000  ? 328 TYR B CA  1 
ATOM   3530 C C   . TYR B 1 210 ? 12.70999  -7.41656  -17.44125 1.000 38.05000  ? 328 TYR B C   1 
ATOM   3531 O O   . TYR B 1 210 ? 12.30209  -8.54051  -17.13592 1.000 43.94000  ? 328 TYR B O   1 
ATOM   3532 C CB  . TYR B 1 210 ? 11.85514  -6.19581  -19.46804 1.000 49.64000  ? 328 TYR B CB  1 
ATOM   3533 C CG  . TYR B 1 210 ? 10.57490  -5.69985  -20.05054 1.000 43.80000  ? 328 TYR B CG  1 
ATOM   3534 C CD1 . TYR B 1 210 ? 9.51179   -6.57184  -20.25396 1.000 43.46000  ? 328 TYR B CD1 1 
ATOM   3535 C CD2 . TYR B 1 210 ? 10.40281  -4.35288  -20.35365 1.000 39.96000  ? 328 TYR B CD2 1 
ATOM   3536 C CE1 . TYR B 1 210 ? 8.30958   -6.12087  -20.77050 1.000 45.57000  ? 328 TYR B CE1 1 
ATOM   3537 C CE2 . TYR B 1 210 ? 9.20361   -3.88491  -20.85719 1.000 39.74000  ? 328 TYR B CE2 1 
ATOM   3538 C CZ  . TYR B 1 210 ? 8.16049   -4.77391  -21.06461 1.000 47.08000  ? 328 TYR B CZ  1 
ATOM   3539 O OH  . TYR B 1 210 ? 6.96428   -4.32694  -21.57715 1.000 59.02000  ? 328 TYR B OH  1 
ATOM   3540 N N   . MET B 1 211 ? 13.99606  -7.06358  -17.30985 1.000 39.28000  ? 329 MET B N   1 
ATOM   3541 C CA  . MET B 1 211 ? 14.98724  -8.03055  -16.82916 1.000 43.18000  ? 329 MET B CA  1 
ATOM   3542 C C   . MET B 1 211 ? 14.67584  -8.50735  -15.41396 1.000 41.86000  ? 329 MET B C   1 
ATOM   3543 O O   . MET B 1 211 ? 14.65792  -9.71132  -15.15479 1.000 42.77000  ? 329 MET B O   1 
ATOM   3544 C CB  . MET B 1 211 ? 16.38523  -7.43460  -16.88685 1.000 44.07000  ? 329 MET B CB  1 
ATOM   3545 C CG  . MET B 1 211 ? 17.13267  -7.76679  -18.16113 1.000 61.03000  ? 329 MET B CG  1 
ATOM   3546 S SD  . MET B 1 211 ? 18.86677  -7.33282  -17.94694 1.000 93.04000  ? 329 MET B SD  1 
ATOM   3547 C CE  . MET B 1 211 ? 19.32930  -8.50066  -16.65899 1.000 65.47000  ? 329 MET B CE  1 
ATOM   3548 N N   . LEU B 1 212 ? 14.40428  -7.57922  -14.48596 1.000 40.92000  ? 330 LEU B N   1 
ATOM   3549 C CA  . LEU B 1 212 ? 14.11786  -7.98303  -13.11378 1.000 39.28000  ? 330 LEU B CA  1 
ATOM   3550 C C   . LEU B 1 212 ? 12.88587  -8.86898  -13.03713 1.000 39.05000  ? 330 LEU B C   1 
ATOM   3551 O O   . LEU B 1 212 ? 12.84419  -9.81087  -12.24098 1.000 45.82000  ? 330 LEU B O   1 
ATOM   3552 C CB  . LEU B 1 212 ? 13.92130  -6.76890  -12.20186 1.000 43.38000  ? 330 LEU B CB  1 
ATOM   3553 C CG  . LEU B 1 212 ? 13.88995  -7.12470  -10.69480 1.000 38.41000  ? 330 LEU B CG  1 
ATOM   3554 C CD1 . LEU B 1 212 ? 15.20412  -7.75968  -10.24729 1.000 40.67000  ? 330 LEU B CD1 1 
ATOM   3555 C CD2 . LEU B 1 212 ? 13.60735  -5.91458  -9.84484  1.000 39.27000  ? 330 LEU B CD2 1 
ATOM   3556 N N   . LYS B 1 213 ? 11.85653  -8.56905  -13.82672 1.000 37.13000  ? 331 LYS B N   1 
ATOM   3557 C CA  . LYS B 1 213 ? 10.63555  -9.35600  -13.73108 1.000 35.43000  ? 331 LYS B CA  1 
ATOM   3558 C C   . LYS B 1 213 ? 10.89133  -10.79207 -14.13900 1.000 40.43000  ? 331 LYS B C   1 
ATOM   3559 O O   . LYS B 1 213 ? 10.25953  -11.71398 -13.60560 1.000 39.79000  ? 331 LYS B O   1 
ATOM   3560 C CB  . LYS B 1 213 ? 9.52719   -8.75209  -14.59868 1.000 34.39000  ? 331 LYS B CB  1 
ATOM   3561 C CG  . LYS B 1 213 ? 8.09535   -9.15499  -14.19800 1.000 28.35000  ? 331 LYS B CG  1 
ATOM   3562 C CD  . LYS B 1 213 ? 7.60996   -8.54980  -12.85987 1.000 33.58000  ? 331 LYS B CD  1 
ATOM   3563 C CE  . LYS B 1 213 ? 6.16906   -9.01272  -12.59418 1.000 34.36000  ? 331 LYS B CE  1 
ATOM   3564 N NZ  . LYS B 1 213 ? 5.50661   -8.47253  -11.37296 1.000 34.53000  ? 331 LYS B NZ  1 
ATOM   3565 N N   . LYS B 1 214 ? 11.82492  -10.99822 -15.07238 1.000 48.13000  ? 332 LYS B N   1 
ATOM   3566 C CA  . LYS B 1 214 ? 12.09466  -12.34129 -15.57432 1.000 48.84000  ? 332 LYS B CA  1 
ATOM   3567 C C   . LYS B 1 214 ? 12.62111  -13.24516 -14.47043 1.000 48.21000  ? 332 LYS B C   1 
ATOM   3568 O O   . LYS B 1 214 ? 12.31309  -14.44115 -14.44413 1.000 59.68000  ? 332 LYS B O   1 
ATOM   3569 C CB  . LYS B 1 214 ? 13.09015  -12.28348 -16.73276 1.000 50.83000  ? 332 LYS B CB  1 
ATOM   3570 C CG  . LYS B 1 214 ? 12.54556  -12.78264 -18.06346 1.000 57.41000  ? 332 LYS B CG  1 
ATOM   3571 C CD  . LYS B 1 214 ? 13.65209  -12.81582 -19.12994 1.000 68.31000  ? 332 LYS B CD  1 
ATOM   3572 N N   . LEU B 1 215 ? 13.41153  -12.69406 -13.54585 1.000 41.98000  ? 333 LEU B N   1 
ATOM   3573 C CA  . LEU B 1 215 ? 14.00997  -13.49994 -12.49100 1.000 37.80000  ? 333 LEU B CA  1 
ATOM   3574 C C   . LEU B 1 215 ? 12.98437  -14.10578 -11.53647 1.000 44.26000  ? 333 LEU B C   1 
ATOM   3575 O O   . LEU B 1 215 ? 13.35069  -14.98069 -10.74251 1.000 50.62000  ? 333 LEU B O   1 
ATOM   3576 C CB  . LEU B 1 215 ? 15.01233  -12.65587 -11.72055 1.000 40.03000  ? 333 LEU B CB  1 
ATOM   3577 C CG  . LEU B 1 215 ? 16.13600  -12.00501 -12.52113 1.000 38.53000  ? 333 LEU B CG  1 
ATOM   3578 C CD1 . LEU B 1 215 ? 16.92344  -11.14591 -11.57159 1.000 34.10000  ? 333 LEU B CD1 1 
ATOM   3579 C CD2 . LEU B 1 215 ? 17.05869  -13.06112 -13.16039 1.000 43.07000  ? 333 LEU B CD2 1 
ATOM   3580 N N   . GLN B 1 216 ? 11.72335  -13.67775 -11.59798 1.000 47.38000  ? 334 GLN B N   1 
ATOM   3581 C CA  . GLN B 1 216 ? 10.63170  -14.21061 -10.77043 1.000 46.99000  ? 334 GLN B CA  1 
ATOM   3582 C C   . GLN B 1 216 ? 11.00234  -14.27242 -9.28958  1.000 42.50000  ? 334 GLN B C   1 
ATOM   3583 O O   . GLN B 1 216 ? 10.93759  -15.32434 -8.65441  1.000 45.59000  ? 334 GLN B O   1 
ATOM   3584 C CB  . GLN B 1 216 ? 10.19744  -15.58466 -11.26206 1.000 45.49000  ? 334 GLN B CB  1 
ATOM   3585 C CG  . GLN B 1 216 ? 9.96579   -15.64185 -12.75295 1.000 57.12000  ? 334 GLN B CG  1 
ATOM   3586 C CD  . GLN B 1 216 ? 9.31156   -16.94289 -13.17649 1.000 75.23000  ? 334 GLN B CD  1 
ATOM   3587 O OE1 . GLN B 1 216 ? 9.97946   -17.97593 -13.33164 1.000 75.27000  ? 334 GLN B OE1 1 
ATOM   3588 N NE2 . GLN B 1 216 ? 7.99249   -16.90487 -13.34692 1.000 70.09000  ? 334 GLN B NE2 1 
ATOM   3589 N N   . LEU B 1 217 ? 11.35162  -13.11236 -8.73889  1.000 39.16000  ? 335 LEU B N   1 
ATOM   3590 C CA  . LEU B 1 217 ? 11.81322  -13.04919 -7.36410  1.000 36.24000  ? 335 LEU B CA  1 
ATOM   3591 C C   . LEU B 1 217 ? 10.64763  -13.21503 -6.40157  1.000 40.97000  ? 335 LEU B C   1 
ATOM   3592 O O   . LEU B 1 217 ? 9.49450   -12.90603 -6.71911  1.000 38.76000  ? 335 LEU B O   1 
ATOM   3593 C CB  . LEU B 1 217 ? 12.51838  -11.72117 -7.09159  1.000 36.27000  ? 335 LEU B CB  1 
ATOM   3594 C CG  . LEU B 1 217 ? 13.73001  -11.38433 -7.96016  1.000 35.82000  ? 335 LEU B CG  1 
ATOM   3595 C CD1 . LEU B 1 217 ? 14.39125  -10.08829 -7.49662  1.000 35.78000  ? 335 LEU B CD1 1 
ATOM   3596 C CD2 . LEU B 1 217 ? 14.71798  -12.53335 -7.94244  1.000 36.45000  ? 335 LEU B CD2 1 
ATOM   3597 N N   . HIS B 1 218 ? 10.96614  -13.73188 -5.21664  1.000 46.60000  ? 336 HIS B N   1 
ATOM   3598 C CA  . HIS B 1 218 ? 10.03262  -13.78670 -4.10822  1.000 45.88000  ? 336 HIS B CA  1 
ATOM   3599 C C   . HIS B 1 218 ? 9.92096   -12.42061 -3.42736  1.000 46.31000  ? 336 HIS B C   1 
ATOM   3600 O O   . HIS B 1 218 ? 10.76892  -11.53265 -3.58185  1.000 40.79000  ? 336 HIS B O   1 
ATOM   3601 C CB  . HIS B 1 218 ? 10.46704  -14.83357 -3.07127  1.000 47.04000  ? 336 HIS B CB  1 
ATOM   3602 C CG  . HIS B 1 218 ? 10.47077  -16.24664 -3.58009  1.000 52.09000  ? 336 HIS B CG  1 
ATOM   3603 N ND1 . HIS B 1 218 ? 11.20900  -17.24759 -2.98228  1.000 45.34000  ? 336 HIS B ND1 1 
ATOM   3604 C CD2 . HIS B 1 218 ? 9.82530   -16.82676 -4.62073  1.000 49.05000  ? 336 HIS B CD2 1 
ATOM   3605 C CE1 . HIS B 1 218 ? 11.03368  -18.37567 -3.64605  1.000 50.44000  ? 336 HIS B CE1 1 
ATOM   3606 N NE2 . HIS B 1 218 ? 10.19825  -18.14878 -4.64271  1.000 49.61000  ? 336 HIS B NE2 1 
ATOM   3607 N N   . GLU B 1 219 ? 8.85430   -12.27147 -2.64391  1.000 46.84000  ? 337 GLU B N   1 
ATOM   3608 C CA  . GLU B 1 219 ? 8.71370   -11.08435 -1.81401  1.000 43.48000  ? 337 GLU B CA  1 
ATOM   3609 C C   . GLU B 1 219 ? 9.96108   -10.86028 -0.96758  1.000 35.95000  ? 337 GLU B C   1 
ATOM   3610 O O   . GLU B 1 219 ? 10.40919  -9.72727  -0.79193  1.000 40.28000  ? 337 GLU B O   1 
ATOM   3611 C CB  . GLU B 1 219 ? 7.47609   -11.22220 -0.92345  1.000 45.94000  ? 337 GLU B CB  1 
ATOM   3612 C CG  . GLU B 1 219 ? 6.13776   -11.33525 -1.65085  1.000 49.48000  ? 337 GLU B CG  1 
ATOM   3613 C CD  . GLU B 1 219 ? 5.52666   -9.96628  -1.99677  1.000 56.76000  ? 337 GLU B CD  1 
ATOM   3614 O OE1 . GLU B 1 219 ? 4.54432   -9.94636  -2.77534  1.000 59.73000  ? 337 GLU B OE1 1 
ATOM   3615 O OE2 . GLU B 1 219 ? 6.04089   -8.91823  -1.52913  1.000 47.41000  ? 337 GLU B OE2 1 
ATOM   3616 N N   . GLU B 1 220 ? 10.54627  -11.93523 -0.45370  1.000 42.63000  ? 338 GLU B N   1 
ATOM   3617 C CA  . GLU B 1 220 ? 11.71565  -11.81615 0.41078   1.000 39.94000  ? 338 GLU B CA  1 
ATOM   3618 C C   . GLU B 1 220 ? 12.92933  -11.32029 -0.36482  1.000 38.64000  ? 338 GLU B C   1 
ATOM   3619 O O   . GLU B 1 220 ? 13.71257  -10.50824 0.14173   1.000 38.60000  ? 338 GLU B O   1 
ATOM   3620 C CB  . GLU B 1 220 ? 12.01389  -13.17307 1.05883   1.000 46.59000  ? 338 GLU B CB  1 
ATOM   3621 C CG  . GLU B 1 220 ? 10.97332  -13.64290 2.07035   1.000 50.25000  ? 338 GLU B CG  1 
ATOM   3622 C CD  . GLU B 1 220 ? 9.89202   -14.51695 1.45094   1.000 51.59000  ? 338 GLU B CD  1 
ATOM   3623 O OE1 . GLU B 1 220 ? 9.71248   -14.44511 0.21000   1.000 47.11000  ? 338 GLU B OE1 1 
ATOM   3624 O OE2 . GLU B 1 220 ? 9.23833   -15.28383 2.20032   1.000 52.44000  ? 338 GLU B OE2 1 
ATOM   3625 N N   . GLU B 1 221 ? 13.12078  -11.79746 -1.59084  1.000 38.04000  ? 339 GLU B N   1 
ATOM   3626 C CA  . GLU B 1 221 ? 14.26446  -11.31159 -2.34540  1.000 38.53000  ? 339 GLU B CA  1 
ATOM   3627 C C   . GLU B 1 221 ? 14.11435  -9.82664  -2.69954  1.000 39.83000  ? 339 GLU B C   1 
ATOM   3628 O O   . GLU B 1 221 ? 15.09141  -9.06565  -2.61806  1.000 34.61000  ? 339 GLU B O   1 
ATOM   3629 C CB  . GLU B 1 221 ? 14.45290  -12.17876 -3.57737  1.000 39.81000  ? 339 GLU B CB  1 
ATOM   3630 C CG  . GLU B 1 221 ? 14.83402  -13.58773 -3.20635  1.000 38.56000  ? 339 GLU B CG  1 
ATOM   3631 C CD  . GLU B 1 221 ? 14.39154  -14.63785 -4.22401  1.000 45.42000  ? 339 GLU B CD  1 
ATOM   3632 O OE1 . GLU B 1 221 ? 13.32326  -14.48090 -4.86857  1.000 42.24000  ? 339 GLU B OE1 1 
ATOM   3633 O OE2 . GLU B 1 221 ? 15.13045  -15.63789 -4.37020  1.000 48.38000  ? 339 GLU B OE2 1 
ATOM   3634 N N   . TYR B 1 222 ? 12.90320  -9.38365  -3.07407  1.000 36.62000  ? 340 TYR B N   1 
ATOM   3635 C CA  . TYR B 1 222 ? 12.70513  -7.95868  -3.34817  1.000 35.05000  ? 340 TYR B CA  1 
ATOM   3636 C C   . TYR B 1 222 ? 13.02669  -7.12853  -2.12442  1.000 35.64000  ? 340 TYR B C   1 
ATOM   3637 O O   . TYR B 1 222 ? 13.73568  -6.11456  -2.21287  1.000 34.96000  ? 340 TYR B O   1 
ATOM   3638 C CB  . TYR B 1 222 ? 11.26995  -7.66369  -3.77358  1.000 31.23000  ? 340 TYR B CB  1 
ATOM   3639 C CG  . TYR B 1 222 ? 10.96630  -7.80688  -5.25343  1.000 38.43000  ? 340 TYR B CG  1 
ATOM   3640 C CD1 . TYR B 1 222 ? 11.47592  -6.91502  -6.19577  1.000 31.84000  ? 340 TYR B CD1 1 
ATOM   3641 C CD2 . TYR B 1 222 ? 10.14607  -8.85092  -5.70893  1.000 39.27000  ? 340 TYR B CD2 1 
ATOM   3642 C CE1 . TYR B 1 222 ? 11.17632  -7.06620  -7.55962  1.000 31.91000  ? 340 TYR B CE1 1 
ATOM   3643 C CE2 . TYR B 1 222 ? 9.84248   -9.00109  -7.04478  1.000 33.60000  ? 340 TYR B CE2 1 
ATOM   3644 C CZ  . TYR B 1 222 ? 10.35710  -8.11423  -7.97112  1.000 35.67000  ? 340 TYR B CZ  1 
ATOM   3645 O OH  . TYR B 1 222 ? 10.03252  -8.30239  -9.30296  1.000 32.48000  ? 340 TYR B OH  1 
ATOM   3646 N N   . VAL B 1 223 ? 12.53318  -7.55136  -0.96315  1.000 28.21000  ? 341 VAL B N   1 
ATOM   3647 C CA  . VAL B 1 223 ? 12.67370  -6.66221  0.17567   1.000 30.34000  ? 341 VAL B CA  1 
ATOM   3648 C C   . VAL B 1 223 ? 14.11292  -6.68218  0.67805   1.000 30.30000  ? 341 VAL B C   1 
ATOM   3649 O O   . VAL B 1 223 ? 14.59120  -5.69512  1.23970   1.000 35.17000  ? 341 VAL B O   1 
ATOM   3650 C CB  . VAL B 1 223 ? 11.66718  -7.02203  1.28016   1.000 33.40000  ? 341 VAL B CB  1 
ATOM   3651 C CG1 . VAL B 1 223 ? 12.14350  -8.22893  2.11211   1.000 33.60000  ? 341 VAL B CG1 1 
ATOM   3652 C CG2 . VAL B 1 223 ? 11.36958  -5.80891  2.12713   1.000 39.31000  ? 341 VAL B CG2 1 
ATOM   3653 N N   . LEU B 1 224 ? 14.84579  -7.77024  0.44687   1.000 34.52000  ? 342 LEU B N   1 
ATOM   3654 C CA  . LEU B 1 224 ? 16.27492  -7.75124  0.73324   1.000 33.13000  ? 342 LEU B CA  1 
ATOM   3655 C C   . LEU B 1 224 ? 17.04651  -6.88040  -0.26121  1.000 33.82000  ? 342 LEU B C   1 
ATOM   3656 O O   . LEU B 1 224 ? 18.00570  -6.21238  0.13028   1.000 33.29000  ? 342 LEU B O   1 
ATOM   3657 C CB  . LEU B 1 224 ? 16.82689  -9.17326  0.76719   1.000 40.60000  ? 342 LEU B CB  1 
ATOM   3658 C CG  . LEU B 1 224 ? 16.56644  -9.91507  2.08241   1.000 41.19000  ? 342 LEU B CG  1 
ATOM   3659 C CD1 . LEU B 1 224 ? 16.76430  -11.41410 1.87852   1.000 38.14000  ? 342 LEU B CD1 1 
ATOM   3660 C CD2 . LEU B 1 224 ? 17.46595  -9.38495  3.21594   1.000 31.75000  ? 342 LEU B CD2 1 
ATOM   3661 N N   . MET B 1 225 ? 16.65795  -6.85356  -1.54304  1.000 36.78000  ? 343 MET B N   1 
ATOM   3662 C CA  . MET B 1 225 ? 17.23160  -5.83069  -2.41843  1.000 35.19000  ? 343 MET B CA  1 
ATOM   3663 C C   . MET B 1 225 ? 16.94586  -4.42362  -1.91449  1.000 38.44000  ? 343 MET B C   1 
ATOM   3664 O O   . MET B 1 225 ? 17.82085  -3.55165  -1.99499  1.000 45.82000  ? 343 MET B O   1 
ATOM   3665 C CB  . MET B 1 225 ? 16.76096  -5.96087  -3.87221  1.000 35.58000  ? 343 MET B CB  1 
ATOM   3666 C CG  . MET B 1 225 ? 16.91463  -7.32097  -4.53709  1.000 39.61000  ? 343 MET B CG  1 
ATOM   3667 S SD  . MET B 1 225 ? 16.19790  -7.24317  -6.19979  1.000 39.90000  ? 343 MET B SD  1 
ATOM   3668 C CE  . MET B 1 225 ? 17.31457  -6.11931  -7.04043  1.000 29.32000  ? 343 MET B CE  1 
ATOM   3669 N N   . GLN B 1 226 ? 15.73609  -4.15451  -1.41200  1.000 35.08000  ? 344 GLN B N   1 
ATOM   3670 C CA  . GLN B 1 226 ? 15.49334  -2.79744  -0.91908  1.000 40.14000  ? 344 GLN B CA  1 
ATOM   3671 C C   . GLN B 1 226 ? 16.45985  -2.45432  0.20846   1.000 41.98000  ? 344 GLN B C   1 
ATOM   3672 O O   . GLN B 1 226 ? 17.04889  -1.36133  0.22905   1.000 34.88000  ? 344 GLN B O   1 
ATOM   3673 C CB  . GLN B 1 226 ? 14.05155  -2.63033  -0.45047  1.000 36.73000  ? 344 GLN B CB  1 
ATOM   3674 C CG  . GLN B 1 226 ? 13.00407  -2.65645  -1.56201  1.000 34.64000  ? 344 GLN B CG  1 
ATOM   3675 C CD  . GLN B 1 226 ? 11.58931  -2.74433  -1.00638  1.000 34.71000  ? 344 GLN B CD  1 
ATOM   3676 O OE1 . GLN B 1 226 ? 10.64299  -3.09440  -1.70892  1.000 34.13000  ? 344 GLN B OE1 1 
ATOM   3677 N NE2 . GLN B 1 226 ? 11.44788  -2.44216  0.27464   1.000 37.46000  ? 344 GLN B NE2 1 
ATOM   3678 N N   . ALA B 1 227 ? 16.66522  -3.40220  1.13349   1.000 42.77000  ? 345 ALA B N   1 
ATOM   3679 C CA  . ALA B 1 227 ? 17.56672  -3.16808  2.25407   1.000 31.95000  ? 345 ALA B CA  1 
ATOM   3680 C C   . ALA B 1 227 ? 18.98752  -2.93919  1.77142   1.000 35.66000  ? 345 ALA B C   1 
ATOM   3681 O O   . ALA B 1 227 ? 19.67175  -2.02914  2.24700   1.000 41.05000  ? 345 ALA B O   1 
ATOM   3682 C CB  . ALA B 1 227 ? 17.50211  -4.33595  3.22225   1.000 24.14000  ? 345 ALA B CB  1 
ATOM   3683 N N   . ILE B 1 228 ? 19.43507  -3.73133  0.80033   1.000 38.67000  ? 346 ILE B N   1 
ATOM   3684 C CA  . ILE B 1 228 ? 20.79085  -3.58944  0.28172   1.000 37.44000  ? 346 ILE B CA  1 
ATOM   3685 C C   . ILE B 1 228 ? 20.95259  -2.24353  -0.38553  1.000 38.98000  ? 346 ILE B C   1 
ATOM   3686 O O   . ILE B 1 228 ? 22.00466  -1.59755  -0.28408  1.000 41.65000  ? 346 ILE B O   1 
ATOM   3687 C CB  . ILE B 1 228 ? 21.11839  -4.74258  -0.68227  1.000 35.70000  ? 346 ILE B CB  1 
ATOM   3688 C CG1 . ILE B 1 228 ? 21.13069  -6.06848  0.09590   1.000 37.43000  ? 346 ILE B CG1 1 
ATOM   3689 C CG2 . ILE B 1 228 ? 22.43910  -4.49071  -1.35388  1.000 34.86000  ? 346 ILE B CG2 1 
ATOM   3690 C CD1 . ILE B 1 228 ? 21.01228  -7.29359  -0.75188  1.000 34.57000  ? 346 ILE B CD1 1 
ATOM   3691 N N   . SER B 1 229 ? 19.91331  -1.79660  -1.07714  1.000 40.68000  ? 347 SER B N   1 
ATOM   3692 C CA  . SER B 1 229 ? 19.96408  -0.47968  -1.69734  1.000 36.31000  ? 347 SER B CA  1 
ATOM   3693 C C   . SER B 1 229 ? 19.86157  0.60646   -0.64344  1.000 39.75000  ? 347 SER B C   1 
ATOM   3694 O O   . SER B 1 229 ? 20.57057  1.61343   -0.71288  1.000 41.47000  ? 347 SER B O   1 
ATOM   3695 C CB  . SER B 1 229 ? 18.84263  -0.36578  -2.72786  1.000 39.40000  ? 347 SER B CB  1 
ATOM   3696 O OG  . SER B 1 229 ? 18.57152  0.97318   -3.06592  1.000 42.05000  ? 347 SER B OG  1 
ATOM   3697 N N   . LEU B 1 230 ? 19.00000  0.40162   0.35897   1.000 45.53000  ? 348 LEU B N   1 
ATOM   3698 C CA  . LEU B 1 230 ? 18.81448  1.41177   1.39291   1.000 41.27000  ? 348 LEU B CA  1 
ATOM   3699 C C   . LEU B 1 230 ? 20.10981  1.66883   2.13031   1.000 43.35000  ? 348 LEU B C   1 
ATOM   3700 O O   . LEU B 1 230 ? 20.52492  2.82084   2.29798   1.000 46.38000  ? 348 LEU B O   1 
ATOM   3701 C CB  . LEU B 1 230 ? 17.73090  0.98593   2.38244   1.000 42.35000  ? 348 LEU B CB  1 
ATOM   3702 C CG  . LEU B 1 230 ? 17.40640  2.04509   3.44944   1.000 42.34000  ? 348 LEU B CG  1 
ATOM   3703 C CD1 . LEU B 1 230 ? 16.97616  3.34001   2.81246   1.000 34.97000  ? 348 LEU B CD1 1 
ATOM   3704 C CD2 . LEU B 1 230 ? 16.35481  1.55525   4.43397   1.000 36.33000  ? 348 LEU B CD2 1 
ATOM   3705 N N   . PHE B 1 231 ? 20.76498  0.60387   2.58117   1.000 42.34000  ? 349 PHE B N   1 
ATOM   3706 C CA  . PHE B 1 231 ? 21.96534  0.75194   3.39862   1.000 42.44000  ? 349 PHE B CA  1 
ATOM   3707 C C   . PHE B 1 231 ? 23.21896  0.75279   2.53108   1.000 47.90000  ? 349 PHE B C   1 
ATOM   3708 O O   . PHE B 1 231 ? 24.11901  -0.05922  2.69679   1.000 54.67000  ? 349 PHE B O   1 
ATOM   3709 C CB  . PHE B 1 231 ? 22.02677  -0.33692  4.45674   1.000 39.89000  ? 349 PHE B CB  1 
ATOM   3710 C CG  . PHE B 1 231 ? 20.97924  -0.19874  5.53018   1.000 46.51000  ? 349 PHE B CG  1 
ATOM   3711 C CD1 . PHE B 1 231 ? 21.18174  0.65239   6.60798   1.000 42.37000  ? 349 PHE B CD1 1 
ATOM   3712 C CD2 . PHE B 1 231 ? 19.79119  -0.92572  5.46780   1.000 39.67000  ? 349 PHE B CD2 1 
ATOM   3713 C CE1 . PHE B 1 231 ? 20.22117  0.77455   7.59938   1.000 42.21000  ? 349 PHE B CE1 1 
ATOM   3714 C CE2 . PHE B 1 231 ? 18.83763  -0.81156  6.46220   1.000 31.62000  ? 349 PHE B CE2 1 
ATOM   3715 C CZ  . PHE B 1 231 ? 19.05112  0.03858   7.52499   1.000 35.73000  ? 349 PHE B CZ  1 
ATOM   3716 N N   . SER B 1 232 ? 23.27359  1.70566   1.60993   1.000 47.36000  ? 350 SER B N   1 
ATOM   3717 C CA  . SER B 1 232 ? 24.47925  1.91252   0.81937   1.000 49.49000  ? 350 SER B CA  1 
ATOM   3718 C C   . SER B 1 232 ? 25.42860  2.83559   1.57183   1.000 59.14000  ? 350 SER B C   1 
ATOM   3719 O O   . SER B 1 232 ? 25.03079  3.95165   1.92386   1.000 59.27000  ? 350 SER B O   1 
ATOM   3720 C CB  . SER B 1 232 ? 24.13268  2.50935   -0.53256  1.000 47.60000  ? 350 SER B CB  1 
ATOM   3721 O OG  . SER B 1 232 ? 23.59527  1.52525   -1.38919  1.000 55.47000  ? 350 SER B OG  1 
ATOM   3722 N N   . PRO B 1 233 ? 26.68171  2.42359   1.83634   1.000 69.92000  ? 351 PRO B N   1 
ATOM   3723 C CA  . PRO B 1 233 ? 27.56910  3.24967   2.67884   1.000 66.85000  ? 351 PRO B CA  1 
ATOM   3724 C C   . PRO B 1 233 ? 28.15582  4.44656   1.96143   1.000 67.43000  ? 351 PRO B C   1 
ATOM   3725 O O   . PRO B 1 233 ? 28.62114  5.38164   2.62810   1.000 68.08000  ? 351 PRO B O   1 
ATOM   3726 C CB  . PRO B 1 233 ? 28.67425  2.26870   3.09049   1.000 58.13000  ? 351 PRO B CB  1 
ATOM   3727 C CG  . PRO B 1 233 ? 28.76671  1.33154   1.92558   1.000 64.23000  ? 351 PRO B CG  1 
ATOM   3728 C CD  . PRO B 1 233 ? 27.36446  1.20950   1.34721   1.000 68.52000  ? 351 PRO B CD  1 
ATOM   3729 N N   . ASP B 1 234 ? 28.12424  4.45138   0.63144   1.000 67.04000  ? 352 ASP B N   1 
ATOM   3730 C CA  . ASP B 1 234 ? 28.77991  5.45225   -0.20298  1.000 63.78000  ? 352 ASP B CA  1 
ATOM   3731 C C   . ASP B 1 234 ? 27.81065  6.42819   -0.86869  1.000 58.69000  ? 352 ASP B C   1 
ATOM   3732 O O   . ASP B 1 234 ? 28.10020  6.95604   -1.94288  1.000 64.69000  ? 352 ASP B O   1 
ATOM   3733 C CB  . ASP B 1 234 ? 29.67344  4.74509   -1.22327  1.000 60.62000  ? 352 ASP B CB  1 
ATOM   3734 C CG  . ASP B 1 234 ? 28.91104  3.71500   -2.06880  1.000 81.27000  ? 352 ASP B CG  1 
ATOM   3735 O OD1 . ASP B 1 234 ? 27.69714  3.48607   -1.81924  1.000 75.04000  ? 352 ASP B OD1 1 
ATOM   3736 O OD2 . ASP B 1 234 ? 29.54163  3.09586   -2.96200  1.000 81.79000  ? 352 ASP B OD2 1 
ATOM   3737 N N   . ARG B 1 235 ? 26.66694  6.70831   -0.22322  1.000 56.45000  ? 353 ARG B N   1 
ATOM   3738 C CA  . ARG B 1 235 ? 25.84178  7.82928   -0.65701  1.000 56.38000  ? 353 ARG B CA  1 
ATOM   3739 C C   . ARG B 1 235 ? 26.45204  9.13833   -0.16046  1.000 59.27000  ? 353 ARG B C   1 
ATOM   3740 O O   . ARG B 1 235 ? 27.02252  9.19146   0.93829   1.000 58.73000  ? 353 ARG B O   1 
ATOM   3741 C CB  . ARG B 1 235 ? 24.40501  7.72840   -0.12037  1.000 53.19000  ? 353 ARG B CB  1 
ATOM   3742 C CG  . ARG B 1 235 ? 23.64786  6.44738   -0.38787  1.000 47.43000  ? 353 ARG B CG  1 
ATOM   3743 C CD  . ARG B 1 235 ? 23.27822  6.26220   -1.84569  1.000 48.40000  ? 353 ARG B CD  1 
ATOM   3744 N NE  . ARG B 1 235 ? 22.36211  5.13221   -2.00213  1.000 49.37000  ? 353 ARG B NE  1 
ATOM   3745 C CZ  . ARG B 1 235 ? 22.06559  4.56206   -3.16493  1.000 47.20000  ? 353 ARG B CZ  1 
ATOM   3746 N NH1 . ARG B 1 235 ? 22.62511  5.01289   -4.28523  1.000 43.89000  ? 353 ARG B NH1 1 
ATOM   3747 N NH2 . ARG B 1 235 ? 21.21954  3.53508   -3.20442  1.000 32.85000  ? 353 ARG B NH2 1 
ATOM   3748 N N   . PRO B 1 236 ? 26.31973  10.20423  -0.94754  1.000 59.47000  ? 354 PRO B N   1 
ATOM   3749 C CA  . PRO B 1 236 ? 26.74497  11.53828  -0.49490  1.000 50.32000  ? 354 PRO B CA  1 
ATOM   3750 C C   . PRO B 1 236 ? 26.15757  11.91847  0.85930   1.000 55.92000  ? 354 PRO B C   1 
ATOM   3751 O O   . PRO B 1 236 ? 24.94567  11.81054  1.08685   1.000 63.72000  ? 354 PRO B O   1 
ATOM   3752 C CB  . PRO B 1 236 ? 26.21451  12.45414  -1.60379  1.000 53.37000  ? 354 PRO B CB  1 
ATOM   3753 C CG  . PRO B 1 236 ? 26.18795  11.57298  -2.83467  1.000 51.63000  ? 354 PRO B CG  1 
ATOM   3754 C CD  . PRO B 1 236 ? 25.76813  10.22106  -2.31830  1.000 48.20000  ? 354 PRO B CD  1 
ATOM   3755 N N   . GLY B 1 237 ? 27.02198  12.39757  1.75886   1.000 60.21000  ? 355 GLY B N   1 
ATOM   3756 C CA  . GLY B 1 237 ? 26.59456  12.89475  3.05598   1.000 62.74000  ? 355 GLY B CA  1 
ATOM   3757 C C   . GLY B 1 237 ? 26.60502  11.87490  4.17711   1.000 62.38000  ? 355 GLY B C   1 
ATOM   3758 O O   . GLY B 1 237 ? 26.31653  12.22807  5.33019   1.000 58.72000  ? 355 GLY B O   1 
ATOM   3759 N N   . VAL B 1 238 ? 26.90785  10.61685  3.87915   1.000 66.59000  ? 356 VAL B N   1 
ATOM   3760 C CA  . VAL B 1 238 ? 27.00028  9.62599   4.93424   1.000 68.91000  ? 356 VAL B CA  1 
ATOM   3761 C C   . VAL B 1 238 ? 28.25264  9.89806   5.75166   1.000 75.37000  ? 356 VAL B C   1 
ATOM   3762 O O   . VAL B 1 238 ? 29.34141  10.10996  5.19915   1.000 73.58000  ? 356 VAL B O   1 
ATOM   3763 C CB  . VAL B 1 238 ? 27.00298  8.20891   4.34643   1.000 69.28000  ? 356 VAL B CB  1 
ATOM   3764 C CG1 . VAL B 1 238 ? 27.26943  7.18505   5.44345   1.000 70.35000  ? 356 VAL B CG1 1 
ATOM   3765 C CG2 . VAL B 1 238 ? 25.67368  7.91987   3.67505   1.000 57.92000  ? 356 VAL B CG2 1 
ATOM   3766 N N   . LEU B 1 239 ? 28.09222  9.93325   7.07472   1.000 74.17000  ? 357 LEU B N   1 
ATOM   3767 C CA  . LEU B 1 239 ? 29.21263  10.01134  8.00322   1.000 69.24000  ? 357 LEU B CA  1 
ATOM   3768 C C   . LEU B 1 239 ? 29.56883  8.64540   8.56525   1.000 71.07000  ? 357 LEU B C   1 
ATOM   3769 O O   . LEU B 1 239 ? 30.74883  8.27937   8.58978   1.000 73.32000  ? 357 LEU B O   1 
ATOM   3770 C CB  . LEU B 1 239 ? 28.88716  10.98150  9.14724   1.000 68.63000  ? 357 LEU B CB  1 
ATOM   3771 C CG  . LEU B 1 239 ? 28.55898  12.39644  8.64119   1.000 73.61000  ? 357 LEU B CG  1 
ATOM   3772 C CD1 . LEU B 1 239 ? 27.98649  13.31060  9.73232   1.000 62.92000  ? 357 LEU B CD1 1 
ATOM   3773 C CD2 . LEU B 1 239 ? 29.76970  13.02631  7.94958   1.000 62.23000  ? 357 LEU B CD2 1 
ATOM   3774 N N   . GLN B 1 240 ? 28.56098  7.86648   8.96080   1.000 65.20000  ? 358 GLN B N   1 
ATOM   3775 C CA  . GLN B 1 240 ? 28.76123  6.58557   9.62488   1.000 61.81000  ? 358 GLN B CA  1 
ATOM   3776 C C   . GLN B 1 240 ? 29.03276  5.46942   8.62391   1.000 64.56000  ? 358 GLN B C   1 
ATOM   3777 O O   . GLN B 1 240 ? 28.35275  4.44045   8.65934   1.000 63.07000  ? 358 GLN B O   1 
ATOM   3778 C CB  . GLN B 1 240 ? 27.53059  6.24072   10.46946  1.000 64.89000  ? 358 GLN B CB  1 
ATOM   3779 C CG  . GLN B 1 240 ? 27.56323  6.78490   11.88738  1.000 65.68000  ? 358 GLN B CG  1 
ATOM   3780 C CD  . GLN B 1 240 ? 28.72656  6.22398   12.68194  1.000 86.59000  ? 358 GLN B CD  1 
ATOM   3781 O OE1 . GLN B 1 240 ? 29.78762  6.84596   12.77740  1.000 87.78000  ? 358 GLN B OE1 1 
ATOM   3782 N NE2 . GLN B 1 240 ? 28.54077  5.03606   13.24818  1.000 85.67000  ? 358 GLN B NE2 1 
ATOM   3783 N N   . HIS B 1 241 ? 30.02639  5.65828   7.74545   1.000 66.87000  ? 359 HIS B N   1 
ATOM   3784 C CA  . HIS B 1 241 ? 30.33490  4.68613   6.69245   1.000 60.37000  ? 359 HIS B CA  1 
ATOM   3785 C C   . HIS B 1 241 ? 30.41709  3.26120   7.22460   1.000 63.40000  ? 359 HIS B C   1 
ATOM   3786 O O   . HIS B 1 241 ? 29.67986  2.38116   6.77904   1.000 70.91000  ? 359 HIS B O   1 
ATOM   3787 C CB  . HIS B 1 241 ? 31.64961  5.05200   6.00782   1.000 62.73000  ? 359 HIS B CB  1 
ATOM   3788 C CG  . HIS B 1 241 ? 31.51118  6.10386   4.95774   1.000 78.55000  ? 359 HIS B CG  1 
ATOM   3789 N ND1 . HIS B 1 241 ? 31.34336  7.43890   5.26064   1.000 87.15000  ? 359 HIS B ND1 1 
ATOM   3790 C CD2 . HIS B 1 241 ? 31.53559  6.02468   3.60574   1.000 83.65000  ? 359 HIS B CD2 1 
ATOM   3791 C CE1 . HIS B 1 241 ? 31.25589  8.13576   4.14058   1.000 83.09000  ? 359 HIS B CE1 1 
ATOM   3792 N NE2 . HIS B 1 241 ? 31.36842  7.30062   3.12164   1.000 88.53000  ? 359 HIS B NE2 1 
ATOM   3793 N N   . ARG B 1 242 ? 31.31750  3.01430   8.18124   1.000 68.68000  ? 360 ARG B N   1 
ATOM   3794 C CA  . ARG B 1 242 ? 31.61662  1.63934   8.56929   1.000 63.06000  ? 360 ARG B CA  1 
ATOM   3795 C C   . ARG B 1 242 ? 30.39285  0.93645   9.14692   1.000 63.12000  ? 360 ARG B C   1 
ATOM   3796 O O   . ARG B 1 242 ? 30.20172  -0.26257  8.91616   1.000 68.09000  ? 360 ARG B O   1 
ATOM   3797 C CB  . ARG B 1 242 ? 32.78505  1.61144   9.55779   1.000 66.07000  ? 360 ARG B CB  1 
ATOM   3798 N N   . VAL B 1 243 ? 29.54320  1.65558   9.89120   1.000 61.99000  ? 361 VAL B N   1 
ATOM   3799 C CA  . VAL B 1 243 ? 28.32841  1.02869   10.42581  1.000 64.17000  ? 361 VAL B CA  1 
ATOM   3800 C C   . VAL B 1 243 ? 27.32392  0.74657   9.31329   1.000 63.54000  ? 361 VAL B C   1 
ATOM   3801 O O   . VAL B 1 243 ? 26.62090  -0.27441  9.33373   1.000 63.09000  ? 361 VAL B O   1 
ATOM   3802 C CB  . VAL B 1 243 ? 27.70693  1.89485   11.53497  1.000 74.15000  ? 361 VAL B CB  1 
ATOM   3803 C CG1 . VAL B 1 243 ? 26.32008  1.35795   11.93064  1.000 65.40000  ? 361 VAL B CG1 1 
ATOM   3804 C CG2 . VAL B 1 243 ? 28.62245  1.90399   12.73957  1.000 78.71000  ? 361 VAL B CG2 1 
ATOM   3805 N N   . VAL B 1 244 ? 27.23552  1.63944   8.32821   1.000 62.38000  ? 362 VAL B N   1 
ATOM   3806 C CA  . VAL B 1 244 ? 26.34602  1.39132   7.20163   1.000 59.56000  ? 362 VAL B CA  1 
ATOM   3807 C C   . VAL B 1 244 ? 26.86961  0.23019   6.35555   1.000 60.06000  ? 362 VAL B C   1 
ATOM   3808 O O   . VAL B 1 244 ? 26.08537  -0.59186  5.86301   1.000 62.47000  ? 362 VAL B O   1 
ATOM   3809 C CB  . VAL B 1 244 ? 26.14770  2.68621   6.38454   1.000 59.46000  ? 362 VAL B CB  1 
ATOM   3810 C CG1 . VAL B 1 244 ? 25.24617  2.45508   5.19296   1.000 54.25000  ? 362 VAL B CG1 1 
ATOM   3811 C CG2 . VAL B 1 244 ? 25.52711  3.76935   7.25767   1.000 54.74000  ? 362 VAL B CG2 1 
ATOM   3812 N N   . ASP B 1 245 ? 28.19455  0.11113   6.20799   1.000 58.82000  ? 363 ASP B N   1 
ATOM   3813 C CA  . ASP B 1 245 ? 28.75916  -0.96600  5.38889   1.000 55.03000  ? 363 ASP B CA  1 
ATOM   3814 C C   . ASP B 1 245 ? 28.64142  -2.31690  6.08612   1.000 58.99000  ? 363 ASP B C   1 
ATOM   3815 O O   . ASP B 1 245 ? 28.30611  -3.32198  5.44740   1.000 57.68000  ? 363 ASP B O   1 
ATOM   3816 C CB  . ASP B 1 245 ? 30.22002  -0.67409  5.04721   1.000 62.86000  ? 363 ASP B CB  1 
ATOM   3817 C CG  . ASP B 1 245 ? 30.81956  -1.68824  4.06909   1.000 70.73000  ? 363 ASP B CG  1 
ATOM   3818 O OD1 . ASP B 1 245 ? 30.45804  -1.66139  2.87424   1.000 71.84000  ? 363 ASP B OD1 1 
ATOM   3819 O OD2 . ASP B 1 245 ? 31.65672  -2.51721  4.49483   1.000 71.60000  ? 363 ASP B OD2 1 
ATOM   3820 N N   . GLN B 1 246 ? 28.92499  -2.37574  7.38900   1.000 65.68000  ? 364 GLN B N   1 
ATOM   3821 C CA  . GLN B 1 246 ? 28.67227  -3.61563  8.11828   0.790 64.67000  ? 364 GLN B CA  1 
ATOM   3822 C C   . GLN B 1 246 ? 27.21119  -4.02761  7.97597   1.000 61.86000  ? 364 GLN B C   1 
ATOM   3823 O O   . GLN B 1 246 ? 26.90309  -5.21662  7.82127   1.000 58.78000  ? 364 GLN B O   1 
ATOM   3824 C CB  . GLN B 1 246 ? 29.05892  -3.46345  9.59609   1.000 58.50000  ? 364 GLN B CB  1 
ATOM   3825 N N   . LEU B 1 247 ? 26.29922  -3.04458  7.97924   1.000 59.43000  ? 365 LEU B N   1 
ATOM   3826 C CA  . LEU B 1 247 ? 24.87216  -3.33855  7.86290   1.000 53.33000  ? 365 LEU B CA  1 
ATOM   3827 C C   . LEU B 1 247 ? 24.52754  -3.84573  6.46712   1.000 55.75000  ? 365 LEU B C   1 
ATOM   3828 O O   . LEU B 1 247 ? 23.79544  -4.83272  6.31857   1.000 54.55000  ? 365 LEU B O   1 
ATOM   3829 C CB  . LEU B 1 247 ? 24.04635  -2.09448  8.20610   1.000 56.73000  ? 365 LEU B CB  1 
ATOM   3830 C CG  . LEU B 1 247 ? 23.78800  -1.79027  9.68417   1.000 54.31000  ? 365 LEU B CG  1 
ATOM   3831 C CD1 . LEU B 1 247 ? 23.02511  -0.48823  9.82333   1.000 52.13000  ? 365 LEU B CD1 1 
ATOM   3832 C CD2 . LEU B 1 247 ? 23.02926  -2.93716  10.35765  1.000 49.52000  ? 365 LEU B CD2 1 
ATOM   3833 N N   . GLN B 1 248 ? 25.03810  -3.17788  5.42381   1.000 55.02000  ? 366 GLN B N   1 
ATOM   3834 C CA  . GLN B 1 248 ? 24.82750  -3.67706  4.06897   1.000 49.57000  ? 366 GLN B CA  1 
ATOM   3835 C C   . GLN B 1 248 ? 25.32439  -5.10309  3.91894   1.000 57.93000  ? 366 GLN B C   1 
ATOM   3836 O O   . GLN B 1 248 ? 24.67208  -5.92516  3.26133   1.000 62.56000  ? 366 GLN B O   1 
ATOM   3837 C CB  . GLN B 1 248 ? 25.52908  -2.80421  3.04854   1.000 46.12000  ? 366 GLN B CB  1 
ATOM   3838 C CG  . GLN B 1 248 ? 24.97546  -2.98138  1.64881   1.000 49.80000  ? 366 GLN B CG  1 
ATOM   3839 C CD  . GLN B 1 248 ? 25.75803  -2.19355  0.60636   1.000 50.84000  ? 366 GLN B CD  1 
ATOM   3840 O OE1 . GLN B 1 248 ? 26.99804  -2.14758  0.63281   1.000 55.24000  ? 366 GLN B OE1 1 
ATOM   3841 N NE2 . GLN B 1 248 ? 25.03266  -1.52664  -0.28541  1.000 45.13000  ? 366 GLN B NE2 1 
ATOM   3842 N N   . GLU B 1 249 ? 26.48464  -5.41305  4.50748   1.000 57.85000  ? 367 GLU B N   1 
ATOM   3843 C CA  . GLU B 1 249 ? 27.07451  -6.73209  4.31239   1.000 56.62000  ? 367 GLU B CA  1 
ATOM   3844 C C   . GLU B 1 249 ? 26.13469  -7.82900  4.80395   1.000 57.93000  ? 367 GLU B C   1 
ATOM   3845 O O   . GLU B 1 249 ? 25.90235  -8.81809  4.09318   1.000 52.34000  ? 367 GLU B O   1 
ATOM   3846 C CB  . GLU B 1 249 ? 28.44081  -6.79504  5.00281   1.000 64.40000  ? 367 GLU B CB  1 
ATOM   3847 C CG  . GLU B 1 249 ? 29.08980  -8.17505  5.07371   1.000 67.30000  ? 367 GLU B CG  1 
ATOM   3848 C CD  . GLU B 1 249 ? 30.62678  -8.11311  5.02503   1.000 76.22000  ? 367 GLU B CD  1 
ATOM   3849 O OE1 . GLU B 1 249 ? 31.17235  -7.61426  4.00772   1.000 75.41000  ? 367 GLU B OE1 1 
ATOM   3850 O OE2 . GLU B 1 249 ? 31.28419  -8.57000  5.99180   1.000 68.43000  ? 367 GLU B OE2 1 
ATOM   3851 N N   . GLN B 1 250 ? 25.53022  -7.64582  5.99219   1.000 59.23000  ? 368 GLN B N   1 
ATOM   3852 C CA  . GLN B 1 250 ? 24.70443  -8.71272  6.56769   1.000 54.16000  ? 368 GLN B CA  1 
ATOM   3853 C C   . GLN B 1 250 ? 23.41508  -8.93079  5.77129   1.000 53.56000  ? 368 GLN B C   1 
ATOM   3854 O O   . GLN B 1 250 ? 22.90802  -10.05978 5.72166   1.000 51.78000  ? 368 GLN B O   1 
ATOM   3855 C CB  . GLN B 1 250 ? 24.37709  -8.41851  8.03880   1.000 56.87000  ? 368 GLN B CB  1 
ATOM   3856 C CG  . GLN B 1 250 ? 25.49754  -8.68441  9.09334   1.000 72.99000  ? 368 GLN B CG  1 
ATOM   3857 C CD  . GLN B 1 250 ? 26.44237  -9.87547  8.79609   1.000 73.55000  ? 368 GLN B CD  1 
ATOM   3858 O OE1 . GLN B 1 250 ? 26.01730  -11.03847 8.70443   1.000 73.51000  ? 368 GLN B OE1 1 
ATOM   3859 N NE2 . GLN B 1 250 ? 27.73732  -9.57153  8.65248   1.000 65.10000  ? 368 GLN B NE2 1 
ATOM   3860 N N   . PHE B 1 251 ? 22.86284  -7.87785  5.15039   1.000 50.03000  ? 369 PHE B N   1 
ATOM   3861 C CA  . PHE B 1 251 ? 21.71745  -8.07294  4.25891   1.000 45.97000  ? 369 PHE B CA  1 
ATOM   3862 C C   . PHE B 1 251 ? 22.13388  -8.85712  3.02083   1.000 47.67000  ? 369 PHE B C   1 
ATOM   3863 O O   . PHE B 1 251 ? 21.47469  -9.83815  2.64225   1.000 40.66000  ? 369 PHE B O   1 
ATOM   3864 C CB  . PHE B 1 251 ? 21.10031  -6.72797  3.84900   1.000 41.38000  ? 369 PHE B CB  1 
ATOM   3865 C CG  . PHE B 1 251 ? 20.39282  -6.02880  4.96622   1.000 41.51000  ? 369 PHE B CG  1 
ATOM   3866 C CD1 . PHE B 1 251 ? 19.36109  -6.64468  5.63975   1.000 38.67000  ? 369 PHE B CD1 1 
ATOM   3867 C CD2 . PHE B 1 251 ? 20.78203  -4.75876  5.36288   1.000 40.44000  ? 369 PHE B CD2 1 
ATOM   3868 C CE1 . PHE B 1 251 ? 18.72857  -6.01352  6.69194   1.000 39.17000  ? 369 PHE B CE1 1 
ATOM   3869 C CE2 . PHE B 1 251 ? 20.14150  -4.11560  6.39907   1.000 36.19000  ? 369 PHE B CE2 1 
ATOM   3870 C CZ  . PHE B 1 251 ? 19.11777  -4.74848  7.06660   1.000 42.38000  ? 369 PHE B CZ  1 
ATOM   3871 N N   . ALA B 1 252 ? 23.23261  -8.43823  2.37630   1.000 40.51000  ? 370 ALA B N   1 
ATOM   3872 C CA  . ALA B 1 252 ? 23.71508  -9.17140  1.21319   1.000 36.50000  ? 370 ALA B CA  1 
ATOM   3873 C C   . ALA B 1 252 ? 23.95019  -10.63837 1.55328   1.000 45.38000  ? 370 ALA B C   1 
ATOM   3874 O O   . ALA B 1 252 ? 23.56283  -11.53446 0.78957   1.000 47.03000  ? 370 ALA B O   1 
ATOM   3875 C CB  . ALA B 1 252 ? 24.98887  -8.53051  0.67654   1.000 35.23000  ? 370 ALA B CB  1 
ATOM   3876 N N   . ILE B 1 253 ? 24.55168  -10.90823 2.71305   1.000 46.12000  ? 371 ILE B N   1 
ATOM   3877 C CA  . ILE B 1 253 ? 24.80781  -12.28919 3.09513   1.000 43.86000  ? 371 ILE B CA  1 
ATOM   3878 C C   . ILE B 1 253 ? 23.49788  -13.03912 3.31280   1.000 45.04000  ? 371 ILE B C   1 
ATOM   3879 O O   . ILE B 1 253 ? 23.34565  -14.17717 2.85602   1.000 50.60000  ? 371 ILE B O   1 
ATOM   3880 C CB  . ILE B 1 253 ? 25.72635  -12.32705 4.32873   1.000 51.14000  ? 371 ILE B CB  1 
ATOM   3881 C CG1 . ILE B 1 253 ? 27.17617  -12.10615 3.90507   1.000 54.54000  ? 371 ILE B CG1 1 
ATOM   3882 C CG2 . ILE B 1 253 ? 25.60362  -13.62795 5.05196   1.000 44.53000  ? 371 ILE B CG2 1 
ATOM   3883 C CD1 . ILE B 1 253 ? 28.09368  -11.80302 5.05863   1.000 60.23000  ? 371 ILE B CD1 1 
ATOM   3884 N N   . THR B 1 254 ? 22.51919  -12.40600 3.97814   1.000 43.37000  ? 372 THR B N   1 
ATOM   3885 C CA  . THR B 1 254 ? 21.21026  -13.03693 4.17880   1.000 45.85000  ? 372 THR B CA  1 
ATOM   3886 C C   . THR B 1 254 ? 20.53967  -13.38509 2.85214   1.000 48.50000  ? 372 THR B C   1 
ATOM   3887 O O   . THR B 1 254 ? 19.91258  -14.44509 2.71655   1.000 49.79000  ? 372 THR B O   1 
ATOM   3888 C CB  . THR B 1 254 ? 20.29264  -12.11480 4.98207   1.000 48.62000  ? 372 THR B CB  1 
ATOM   3889 O OG1 . THR B 1 254 ? 20.78523  -11.96263 6.31784   1.000 45.69000  ? 372 THR B OG1 1 
ATOM   3890 C CG2 . THR B 1 254 ? 18.86764  -12.67575 5.02177   1.000 48.72000  ? 372 THR B CG2 1 
ATOM   3891 N N   . LEU B 1 255 ? 20.64527  -12.49422 1.86697   1.000 41.25000  ? 373 LEU B N   1 
ATOM   3892 C CA  . LEU B 1 255 ? 20.07569  -12.77238 0.55926   1.000 41.35000  ? 373 LEU B CA  1 
ATOM   3893 C C   . LEU B 1 255 ? 20.70138  -14.02048 -0.06785  1.000 45.74000  ? 373 LEU B C   1 
ATOM   3894 O O   . LEU B 1 255 ? 19.99811  -14.87254 -0.62343  1.000 50.12000  ? 373 LEU B O   1 
ATOM   3895 C CB  . LEU B 1 255 ? 20.26733  -11.55651 -0.33399  1.000 41.33000  ? 373 LEU B CB  1 
ATOM   3896 C CG  . LEU B 1 255 ? 19.59374  -11.64367 -1.69168  1.000 41.98000  ? 373 LEU B CG  1 
ATOM   3897 C CD1 . LEU B 1 255 ? 18.08981  -11.79460 -1.50701  1.000 39.91000  ? 373 LEU B CD1 1 
ATOM   3898 C CD2 . LEU B 1 255 ? 19.92344  -10.39378 -2.45800  1.000 38.55000  ? 373 LEU B CD2 1 
ATOM   3899 N N   . LYS B 1 256 ? 22.02641  -14.14551 0.01659   1.000 45.09000  ? 374 LYS B N   1 
ATOM   3900 C CA  . LYS B 1 256 ? 22.71011  -15.28162 -0.59456  1.000 44.27000  ? 374 LYS B CA  1 
ATOM   3901 C C   . LYS B 1 256 ? 22.25734  -16.59152 0.03481   1.000 47.37000  ? 374 LYS B C   1 
ATOM   3902 O O   . LYS B 1 256 ? 21.96300  -17.56260 -0.67393  1.000 44.76000  ? 374 LYS B O   1 
ATOM   3903 C CB  . LYS B 1 256 ? 24.21917  -15.08464 -0.46524  1.000 39.41000  ? 374 LYS B CB  1 
ATOM   3904 C CG  . LYS B 1 256 ? 25.09075  -15.95279 -1.35551  1.000 48.88000  ? 374 LYS B CG  1 
ATOM   3905 C CD  . LYS B 1 256 ? 26.57295  -15.85478 -0.91617  1.000 44.89000  ? 374 LYS B CD  1 
ATOM   3906 C CE  . LYS B 1 256 ? 27.48257  -16.77291 -1.72644  1.000 44.79000  ? 374 LYS B CE  1 
ATOM   3907 N N   . SER B 1 257 ? 22.14692  -16.61234 1.36686   1.000 52.51000  ? 375 SER B N   1 
ATOM   3908 C CA  . SER B 1 257 ? 21.71320  -17.81223 2.07921   1.000 48.37000  ? 375 SER B CA  1 
ATOM   3909 C C   . SER B 1 257 ? 20.27903  -18.15523 1.73089   1.000 56.42000  ? 375 SER B C   1 
ATOM   3910 O O   . SER B 1 257 ? 19.95888  -19.31726 1.45818   1.000 59.27000  ? 375 SER B O   1 
ATOM   3911 C CB  . SER B 1 257 ? 21.84786  -17.60803 3.58613   1.000 49.81000  ? 375 SER B CB  1 
ATOM   3912 O OG  . SER B 1 257 ? 23.18103  -17.24902 3.94050   1.000 61.91000  ? 375 SER B OG  1 
ATOM   3913 N N   . TYR B 1 258 ? 19.39508  -17.15020 1.75414   1.000 56.67000  ? 376 TYR B N   1 
ATOM   3914 C CA  . TYR B 1 258 ? 18.01889  -17.37222 1.33577   1.000 49.32000  ? 376 TYR B CA  1 
ATOM   3915 C C   . TYR B 1 258 ? 17.98528  -18.06939 -0.01012  1.000 53.05000  ? 376 TYR B C   1 
ATOM   3916 O O   . TYR B 1 258 ? 17.32918  -19.10640 -0.16770  1.000 56.42000  ? 376 TYR B O   1 
ATOM   3917 C CB  . TYR B 1 258 ? 17.23090  -16.05220 1.27294   1.000 45.25000  ? 376 TYR B CB  1 
ATOM   3918 C CG  . TYR B 1 258 ? 15.76373  -16.27220 0.90661   1.000 52.25000  ? 376 TYR B CG  1 
ATOM   3919 C CD1 . TYR B 1 258 ? 15.35215  -16.32237 -0.43121  1.000 47.29000  ? 376 TYR B CD1 1 
ATOM   3920 C CD2 . TYR B 1 258 ? 14.79416  -16.47404 1.89406   1.000 51.71000  ? 376 TYR B CD2 1 
ATOM   3921 C CE1 . TYR B 1 258 ? 14.01799  -16.55938 -0.76959  1.000 47.81000  ? 376 TYR B CE1 1 
ATOM   3922 C CE2 . TYR B 1 258 ? 13.44800  -16.69905 1.56167   1.000 46.49000  ? 376 TYR B CE2 1 
ATOM   3923 C CZ  . TYR B 1 258 ? 13.07542  -16.74021 0.22784   1.000 50.76000  ? 376 TYR B CZ  1 
ATOM   3924 O OH  . TYR B 1 258 ? 11.76926  -16.97022 -0.11656  1.000 51.31000  ? 376 TYR B OH  1 
ATOM   3925 N N   . ILE B 1 259 ? 18.69686  -17.51655 -0.99451  1.000 45.63000  ? 377 ILE B N   1 
ATOM   3926 C CA  . ILE B 1 259 ? 18.59826  -18.06172 -2.34339  1.000 51.95000  ? 377 ILE B CA  1 
ATOM   3927 C C   . ILE B 1 259 ? 19.10721  -19.49874 -2.36542  1.000 62.81000  ? 377 ILE B C   1 
ATOM   3928 O O   . ILE B 1 259 ? 18.50490  -20.37681 -2.99804  1.000 59.74000  ? 377 ILE B O   1 
ATOM   3929 C CB  . ILE B 1 259 ? 19.34585  -17.15488 -3.33484  1.000 43.82000  ? 377 ILE B CB  1 
ATOM   3930 C CG1 . ILE B 1 259 ? 18.60785  -15.80987 -3.43270  1.000 45.02000  ? 377 ILE B CG1 1 
ATOM   3931 C CG2 . ILE B 1 259 ? 19.50625  -17.84806 -4.67182  1.000 38.14000  ? 377 ILE B CG2 1 
ATOM   3932 C CD1 . ILE B 1 259 ? 19.17345  -14.79102 -4.41908  1.000 41.34000  ? 377 ILE B CD1 1 
ATOM   3933 N N   . GLU B 1 260 ? 20.17753  -19.77767 -1.61185  1.000 62.12000  ? 378 GLU B N   1 
ATOM   3934 C CA  . GLU B 1 260 ? 20.69852  -21.13968 -1.51990  1.000 53.39000  ? 378 GLU B CA  1 
ATOM   3935 C C   . GLU B 1 260 ? 19.72681  -22.07755 -0.79435  1.000 58.46000  ? 378 GLU B C   1 
ATOM   3936 O O   . GLU B 1 260 ? 19.46557  -23.18661 -1.26909  1.000 59.04000  ? 378 GLU B O   1 
ATOM   3937 C CB  . GLU B 1 260 ? 22.06382  -21.12463 -0.84350  1.000 50.64000  ? 378 GLU B CB  1 
ATOM   3938 C CG  . GLU B 1 260 ? 23.16241  -20.78779 -1.81802  1.000 54.69000  ? 378 GLU B CG  1 
ATOM   3939 C CD  . GLU B 1 260 ? 24.53669  -20.70575 -1.17563  1.000 72.08000  ? 378 GLU B CD  1 
ATOM   3940 O OE1 . GLU B 1 260 ? 24.61723  -20.50459 0.06031   1.000 72.39000  ? 378 GLU B OE1 1 
ATOM   3941 O OE2 . GLU B 1 260 ? 25.53836  -20.82488 -1.92105  1.000 78.23000  ? 378 GLU B OE2 1 
ATOM   3942 N N   . CYS B 1 261 ? 19.17433  -21.65538 0.35384   1.000 64.77000  ? 379 CYS B N   1 
ATOM   3943 C CA  . CYS B 1 261 ? 18.15461  -22.45426 1.05039   1.000 66.89000  ? 379 CYS B CA  1 
ATOM   3944 C C   . CYS B 1 261 ? 16.87525  -22.68233 0.24798   1.000 67.47000  ? 379 CYS B C   1 
ATOM   3945 O O   . CYS B 1 261 ? 16.05541  -23.49924 0.68144   1.000 75.31000  ? 379 CYS B O   1 
ATOM   3946 C CB  . CYS B 1 261 ? 17.71721  -21.81807 2.39049   1.000 65.96000  ? 379 CYS B CB  1 
ATOM   3947 S SG  . CYS B 1 261 ? 18.70985  -22.18490 3.88811   1.000 94.56000  ? 379 CYS B SG  1 
ATOM   3948 N N   . ASN B 1 262 ? 16.65678  -21.97947 -0.87302  1.000 70.12000  ? 380 ASN B N   1 
ATOM   3949 C CA  . ASN B 1 262 ? 15.31952  -21.94651 -1.48344  1.000 66.19000  ? 380 ASN B CA  1 
ATOM   3950 C C   . ASN B 1 262 ? 15.27985  -22.08271 -3.00141  1.000 63.02000  ? 380 ASN B C   1 
ATOM   3951 O O   . ASN B 1 262 ? 14.19761  -22.36475 -3.52790  1.000 58.51000  ? 380 ASN B O   1 
ATOM   3952 C CB  . ASN B 1 262 ? 14.58171  -20.64544 -1.12029  1.000 64.15000  ? 380 ASN B CB  1 
ATOM   3953 C CG  . ASN B 1 262 ? 13.87230  -20.70324 0.22602   1.000 70.08000  ? 380 ASN B CG  1 
ATOM   3954 O OD1 . ASN B 1 262 ? 14.45877  -20.39112 1.27673   1.000 71.30000  ? 380 ASN B OD1 1 
ATOM   3955 N ND2 . ASN B 1 262 ? 12.60028  -21.10020 0.20063   1.000 71.70000  ? 380 ASN B ND2 1 
ATOM   3956 N N   . ARG B 1 263 ? 16.37754  -21.86784 -3.73391  1.000 63.52000  ? 381 ARG B N   1 
ATOM   3957 C CA  . ARG B 1 263 ? 16.36290  -21.79204 -5.19892  1.000 68.43000  ? 381 ARG B CA  1 
ATOM   3958 C C   . ARG B 1 263 ? 17.16759  -22.93615 -5.81512  1.000 71.51000  ? 381 ARG B C   1 
ATOM   3959 O O   . ARG B 1 263 ? 18.15729  -22.70827 -6.52658  1.000 64.18000  ? 381 ARG B O   1 
ATOM   3960 C CB  . ARG B 1 263 ? 16.91173  -20.45012 -5.68534  1.000 64.63000  ? 381 ARG B CB  1 
ATOM   3961 C CG  . ARG B 1 263 ? 16.20500  -19.22303 -5.14719  1.000 58.21000  ? 381 ARG B CG  1 
ATOM   3962 C CD  . ARG B 1 263 ? 14.79979  -19.19705 -5.62758  1.000 57.15000  ? 381 ARG B CD  1 
ATOM   3963 N NE  . ARG B 1 263 ? 14.35471  -17.85407 -5.90457  1.000 47.67000  ? 381 ARG B NE  1 
ATOM   3964 C CZ  . ARG B 1 263 ? 13.30639  -17.56914 -6.66415  1.000 56.42000  ? 381 ARG B CZ  1 
ATOM   3965 N NH1 . ARG B 1 263 ? 12.61011  -18.54820 -7.23571  1.000 59.15000  ? 381 ARG B NH1 1 
ATOM   3966 N NH2 . ARG B 1 263 ? 12.95434  -16.29916 -6.85516  1.000 53.67000  ? 381 ARG B NH2 1 
ATOM   3967 N N   . PRO B 1 264 ? 16.75766  -24.18610 -5.58477  1.000 74.94000  ? 382 PRO B N   1 
ATOM   3968 C CA  . PRO B 1 264 ? 17.56741  -25.31019 -6.07397  1.000 75.66000  ? 382 PRO B CA  1 
ATOM   3969 C C   . PRO B 1 264 ? 17.55275  -25.45839 -7.58595  1.000 70.35000  ? 382 PRO B C   1 
ATOM   3970 O O   . PRO B 1 264 ? 18.45148  -26.10649 -8.13825  1.000 71.10000  ? 382 PRO B O   1 
ATOM   3971 C CB  . PRO B 1 264 ? 16.92768  -26.51608 -5.37553  1.000 81.49000  ? 382 PRO B CB  1 
ATOM   3972 C CG  . PRO B 1 264 ? 15.46576  -26.11501 -5.22495  1.000 62.30000  ? 382 PRO B CG  1 
ATOM   3973 C CD  . PRO B 1 264 ? 15.45288  -24.63299 -5.04714  1.000 60.56000  ? 382 PRO B CD  1 
ATOM   3974 N N   . GLN B 1 265 ? 16.57647  -24.86945 -8.26760  1.000 72.07000  ? 383 GLN B N   1 
ATOM   3975 C CA  . GLN B 1 265 ? 16.41984  -25.08364 -9.69350  1.000 71.72000  ? 383 GLN B CA  1 
ATOM   3976 C C   . GLN B 1 265 ? 17.56352  -24.42878 -10.47509 1.000 75.46000  ? 383 GLN B C   1 
ATOM   3977 O O   . GLN B 1 265 ? 18.09272  -23.38274 -10.07146 1.000 69.91000  ? 383 GLN B O   1 
ATOM   3978 C CB  . GLN B 1 265 ? 15.07065  -24.53366 -10.16099 1.000 71.08000  ? 383 GLN B CB  1 
ATOM   3979 N N   . PRO B 1 266 ? 17.97201  -25.03894 -11.59719 1.000 81.64000  ? 384 PRO B N   1 
ATOM   3980 C CA  . PRO B 1 266 ? 19.04666  -24.46209 -12.42573 1.000 74.64000  ? 384 PRO B CA  1 
ATOM   3981 C C   . PRO B 1 266 ? 18.64436  -23.22418 -13.20672 1.000 77.55000  ? 384 PRO B C   1 
ATOM   3982 O O   . PRO B 1 266 ? 19.50108  -22.63429 -13.88618 1.000 73.40000  ? 384 PRO B O   1 
ATOM   3983 C CB  . PRO B 1 266 ? 19.41221  -25.61622 -13.37574 1.000 72.88000  ? 384 PRO B CB  1 
ATOM   3984 C CG  . PRO B 1 266 ? 18.17415  -26.44520 -13.45609 1.000 72.41000  ? 384 PRO B CG  1 
ATOM   3985 C CD  . PRO B 1 266 ? 17.54375  -26.36399 -12.08982 1.000 77.25000  ? 384 PRO B CD  1 
ATOM   3986 N N   . ALA B 1 267 ? 17.37740  -22.80913 -13.14723 1.000 81.10000  ? 385 ALA B N   1 
ATOM   3987 C CA  . ALA B 1 267 ? 17.02919  -21.50820 -13.70625 1.000 74.92000  ? 385 ALA B CA  1 
ATOM   3988 C C   . ALA B 1 267 ? 17.61560  -20.38010 -12.86166 1.000 75.12000  ? 385 ALA B C   1 
ATOM   3989 O O   . ALA B 1 267 ? 17.89740  -19.29218 -13.38192 1.000 76.00000  ? 385 ALA B O   1 
ATOM   3990 C CB  . ALA B 1 267 ? 15.50914  -21.38817 -13.82760 1.000 65.73000  ? 385 ALA B CB  1 
ATOM   3991 N N   . HIS B 1 268 ? 17.84115  -20.63793 -11.57072 1.000 65.31000  ? 386 HIS B N   1 
ATOM   3992 C CA  . HIS B 1 268 ? 18.27860  -19.62882 -10.62404 1.000 56.09000  ? 386 HIS B CA  1 
ATOM   3993 C C   . HIS B 1 268 ? 19.76874  -19.74782 -10.28368 1.000 62.32000  ? 386 HIS B C   1 
ATOM   3994 O O   . HIS B 1 268 ? 20.20023  -19.31169 -9.19893  1.000 51.15000  ? 386 HIS B O   1 
ATOM   3995 C CB  . HIS B 1 268 ? 17.41914  -19.72163 -9.37066  1.000 59.31000  ? 386 HIS B CB  1 
ATOM   3996 C CG  . HIS B 1 268 ? 15.99001  -20.08362 -9.64398  1.000 72.83000  ? 386 HIS B CG  1 
ATOM   3997 N ND1 . HIS B 1 268 ? 15.13672  -19.27069 -10.36372 1.000 70.73000  ? 386 HIS B ND1 1 
ATOM   3998 C CD2 . HIS B 1 268 ? 15.25614  -21.16355 -9.27352  1.000 73.54000  ? 386 HIS B CD2 1 
ATOM   3999 C CE1 . HIS B 1 268 ? 13.94667  -19.84367 -10.44112 1.000 70.03000  ? 386 HIS B CE1 1 
ATOM   4000 N NE2 . HIS B 1 268 ? 13.99192  -20.99358 -9.78899  1.000 66.78000  ? 386 HIS B NE2 1 
ATOM   4001 N N   . ARG B 1 269 ? 20.56033  -20.33796 -11.17895 1.000 54.21000  ? 387 ARG B N   1 
ATOM   4002 C CA  . ARG B 1 269 ? 22.00042  -20.35098 -10.97557 1.000 48.94000  ? 387 ARG B CA  1 
ATOM   4003 C C   . ARG B 1 269 ? 22.52342  -18.92401 -11.07099 1.000 47.10000  ? 387 ARG B C   1 
ATOM   4004 O O   . ARG B 1 269 ? 22.06809  -18.13111 -11.89290 1.000 50.50000  ? 387 ARG B O   1 
ATOM   4005 C CB  . ARG B 1 269 ? 22.68095  -21.26114 -11.99775 1.000 46.03000  ? 387 ARG B CB  1 
ATOM   4006 C CG  . ARG B 1 269 ? 22.45302  -22.75310 -11.72945 1.000 45.14000  ? 387 ARG B CG  1 
ATOM   4007 C CD  . ARG B 1 269 ? 23.12454  -23.63825 -12.76362 1.000 39.97000  ? 387 ARG B CD  1 
ATOM   4008 N NE  . ARG B 1 269 ? 24.57460  -23.59028 -12.63026 1.000 40.75000  ? 387 ARG B NE  1 
ATOM   4009 C CZ  . ARG B 1 269 ? 25.44119  -24.03943 -13.53358 1.000 36.88000  ? 387 ARG B CZ  1 
ATOM   4010 N NH1 . ARG B 1 269 ? 25.02168  -24.59757 -14.66032 1.000 32.78000  ? 387 ARG B NH1 1 
ATOM   4011 N NH2 . ARG B 1 269 ? 26.74129  -23.91144 -13.30817 1.000 40.80000  ? 387 ARG B NH2 1 
ATOM   4012 N N   . PHE B 1 270 ? 23.44582  -18.57892 -10.18944 1.000 44.72000  ? 388 PHE B N   1 
ATOM   4013 C CA  . PHE B 1 270 ? 23.98791  -17.22792 -10.08286 1.000 48.71000  ? 388 PHE B CA  1 
ATOM   4014 C C   . PHE B 1 270 ? 22.93908  -16.16985 -9.75754  1.000 46.09000  ? 388 PHE B C   1 
ATOM   4015 O O   . PHE B 1 270 ? 23.23806  -14.97287 -9.88983  1.000 46.89000  ? 388 PHE B O   1 
ATOM   4016 C CB  . PHE B 1 270 ? 24.73936  -16.80912 -11.35824 1.000 44.00000  ? 388 PHE B CB  1 
ATOM   4017 C CG  . PHE B 1 270 ? 25.54106  -17.91022 -11.96544 1.000 45.44000  ? 388 PHE B CG  1 
ATOM   4018 C CD1 . PHE B 1 270 ? 26.65434  -18.42117 -11.29786 1.000 39.68000  ? 388 PHE B CD1 1 
ATOM   4019 C CD2 . PHE B 1 270 ? 25.16451  -18.46437 -13.19221 1.000 45.35000  ? 388 PHE B CD2 1 
ATOM   4020 C CE1 . PHE B 1 270 ? 27.38607  -19.46526 -11.85004 1.000 41.38000  ? 388 PHE B CE1 1 
ATOM   4021 C CE2 . PHE B 1 270 ? 25.89023  -19.50447 -13.76038 1.000 39.63000  ? 388 PHE B CE2 1 
ATOM   4022 C CZ  . PHE B 1 270 ? 27.00551  -20.00942 -13.08680 1.000 40.89000  ? 388 PHE B CZ  1 
ATOM   4023 N N   . LEU B 1 271 ? 21.73026  -16.56275 -9.31996  1.000 39.64000  ? 389 LEU B N   1 
ATOM   4024 C CA  . LEU B 1 271 ? 20.67641  -15.58068 -9.05263  1.000 42.30000  ? 389 LEU B CA  1 
ATOM   4025 C C   . LEU B 1 271 ? 21.14585  -14.47457 -8.11198  1.000 45.04000  ? 389 LEU B C   1 
ATOM   4026 O O   . LEU B 1 271 ? 20.83580  -13.28659 -8.31901  1.000 41.13000  ? 389 LEU B O   1 
ATOM   4027 C CB  . LEU B 1 271 ? 19.44264  -16.26157 -8.46600  1.000 48.92000  ? 389 LEU B CB  1 
ATOM   4028 C CG  . LEU B 1 271 ? 18.27378  -15.30650 -8.21062  1.000 47.54000  ? 389 LEU B CG  1 
ATOM   4029 C CD1 . LEU B 1 271 ? 17.90124  -14.59466 -9.50755  1.000 35.12000  ? 389 LEU B CD1 1 
ATOM   4030 C CD2 . LEU B 1 271 ? 17.07901  -16.05939 -7.63900  1.000 47.68000  ? 389 LEU B CD2 1 
ATOM   4031 N N   . PHE B 1 272 ? 21.89829  -14.83846 -7.07326  1.000 43.01000  ? 390 PHE B N   1 
ATOM   4032 C CA  . PHE B 1 272 ? 22.37173  -13.81635 -6.14961  1.000 40.91000  ? 390 PHE B CA  1 
ATOM   4033 C C   . PHE B 1 272 ? 23.31445  -12.83547 -6.84215  1.000 43.67000  ? 390 PHE B C   1 
ATOM   4034 O O   . PHE B 1 272 ? 23.28061  -11.63143 -6.57030  1.000 46.06000  ? 390 PHE B O   1 
ATOM   4035 C CB  . PHE B 1 272 ? 23.05923  -14.45721 -4.95082  1.000 43.01000  ? 390 PHE B CB  1 
ATOM   4036 C CG  . PHE B 1 272 ? 23.78064  -13.46811 -4.08427  1.000 47.19000  ? 390 PHE B CG  1 
ATOM   4037 C CD1 . PHE B 1 272 ? 23.06803  -12.62798 -3.23907  1.000 42.46000  ? 390 PHE B CD1 1 
ATOM   4038 C CD2 . PHE B 1 272 ? 25.17362  -13.35316 -4.13589  1.000 43.49000  ? 390 PHE B CD2 1 
ATOM   4039 C CE1 . PHE B 1 272 ? 23.72141  -11.70189 -2.43048  1.000 38.84000  ? 390 PHE B CE1 1 
ATOM   4040 C CE2 . PHE B 1 272 ? 25.85100  -12.41908 -3.33331  1.000 41.36000  ? 390 PHE B CE2 1 
ATOM   4041 C CZ  . PHE B 1 272 ? 25.12440  -11.59594 -2.48011  1.000 45.46000  ? 390 PHE B CZ  1 
ATOM   4042 N N   . LEU B 1 273 ? 24.16905  -13.32061 -7.73346  1.000 42.39000  ? 391 LEU B N   1 
ATOM   4043 C CA  . LEU B 1 273 ? 25.07879  -12.40073 -8.39698  1.000 38.61000  ? 391 LEU B CA  1 
ATOM   4044 C C   . LEU B 1 273 ? 24.35835  -11.57085 -9.46878  1.000 41.65000  ? 391 LEU B C   1 
ATOM   4045 O O   . LEU B 1 273 ? 24.67031  -10.38488 -9.64007  1.000 39.01000  ? 391 LEU B O   1 
ATOM   4046 C CB  . LEU B 1 273 ? 26.26951  -13.17284 -8.97440  1.000 41.93000  ? 391 LEU B CB  1 
ATOM   4047 C CG  . LEU B 1 273 ? 27.26192  -13.82274 -7.98874  1.000 43.17000  ? 391 LEU B CG  1 
ATOM   4048 C CD1 . LEU B 1 273 ? 28.22157  -14.71787 -8.73104  1.000 37.12000  ? 391 LEU B CD1 1 
ATOM   4049 C CD2 . LEU B 1 273 ? 28.04030  -12.79366 -7.20522  1.000 39.38000  ? 391 LEU B CD2 1 
ATOM   4050 N N   . LYS B 1 274 ? 23.40201  -12.15692 -10.20828 1.000 40.07000  ? 392 LYS B N   1 
ATOM   4051 C CA  . LYS B 1 274 ? 22.59063  -11.34702 -11.12103 1.000 37.88000  ? 392 LYS B CA  1 
ATOM   4052 C C   . LYS B 1 274 ? 21.90000  -10.22790 -10.36288 1.000 40.98000  ? 392 LYS B C   1 
ATOM   4053 O O   . LYS B 1 274 ? 21.89884  -9.07095  -10.80004 1.000 37.78000  ? 392 LYS B O   1 
ATOM   4054 C CB  . LYS B 1 274 ? 21.51730  -12.18708 -11.82645 1.000 44.29000  ? 392 LYS B CB  1 
ATOM   4055 C CG  . LYS B 1 274 ? 22.00984  -13.25323 -12.81153 1.000 51.15000  ? 392 LYS B CG  1 
ATOM   4056 C CD  . LYS B 1 274 ? 20.85251  -13.91629 -13.51893 1.000 57.16000  ? 392 LYS B CD  1 
ATOM   4057 C CE  . LYS B 1 274 ? 21.31604  -14.92843 -14.52500 1.000 51.45000  ? 392 LYS B CE  1 
ATOM   4058 N NZ  . LYS B 1 274 ? 20.17672  -15.53549 -15.21442 1.000 68.99000  ? 392 LYS B NZ  1 
ATOM   4059 N N   . ILE B 1 275 ? 21.29249  -10.57172 -9.21757  1.000 43.79000  ? 393 ILE B N   1 
ATOM   4060 C CA  . ILE B 1 275 ? 20.61387  -9.56260  -8.40341  1.000 40.28000  ? 393 ILE B CA  1 
ATOM   4061 C C   . ILE B 1 275 ? 21.57407  -8.43858  -8.03398  1.000 39.79000  ? 393 ILE B C   1 
ATOM   4062 O O   . ILE B 1 275 ? 21.25004  -7.25459  -8.18299  1.000 42.76000  ? 393 ILE B O   1 
ATOM   4063 C CB  . ILE B 1 275 ? 19.97940  -10.18241 -7.14405  1.000 39.96000  ? 393 ILE B CB  1 
ATOM   4064 C CG1 . ILE B 1 275 ? 18.75023  -11.03042 -7.48740  1.000 40.68000  ? 393 ILE B CG1 1 
ATOM   4065 C CG2 . ILE B 1 275 ? 19.57985  -9.08427  -6.18602  1.000 34.45000  ? 393 ILE B CG2 1 
ATOM   4066 C CD1 . ILE B 1 275 ? 18.13273  -11.73324 -6.28004  1.000 36.90000  ? 393 ILE B CD1 1 
ATOM   4067 N N   . MET B 1 276 ? 22.77227  -8.78155  -7.55546  1.000 36.77000  ? 394 MET B N   1 
ATOM   4068 C CA  . MET B 1 276 ? 23.68949  -7.72952  -7.11500  1.000 40.00000  ? 394 MET B CA  1 
ATOM   4069 C C   . MET B 1 276 ? 24.14901  -6.86469  -8.28531  1.000 43.50000  ? 394 MET B C   1 
ATOM   4070 O O   . MET B 1 276 ? 24.35911  -5.65267  -8.12557  1.000 45.40000  ? 394 MET B O   1 
ATOM   4071 C CB  . MET B 1 276 ? 24.89079  -8.33146  -6.38644  1.000 40.93000  ? 394 MET B CB  1 
ATOM   4072 C CG  . MET B 1 276 ? 24.53333  -9.06627  -5.09319  1.000 44.06000  ? 394 MET B CG  1 
ATOM   4073 S SD  . MET B 1 276 ? 23.93195  -7.98408  -3.76307  1.000 43.84000  ? 394 MET B SD  1 
ATOM   4074 C CE  . MET B 1 276 ? 25.13890  -6.66414  -3.96177  1.000 39.32000  ? 394 MET B CE  1 
ATOM   4075 N N   . ALA B 1 277 ? 24.31547  -7.46685  -9.46930  1.000 41.66000  ? 395 ALA B N   1 
ATOM   4076 C CA  . ALA B 1 277 ? 24.59597  -6.68102  -10.66853 1.000 35.96000  ? 395 ALA B CA  1 
ATOM   4077 C C   . ALA B 1 277 ? 23.41985  -5.76703  -11.00714 1.000 43.83000  ? 395 ALA B C   1 
ATOM   4078 O O   . ALA B 1 277 ? 23.61871  -4.60809  -11.40038 1.000 41.03000  ? 395 ALA B O   1 
ATOM   4079 C CB  . ALA B 1 277 ? 24.92443  -7.60619  -11.84255 1.000 22.87000  ? 395 ALA B CB  1 
ATOM   4080 N N   . MET B 1 278 ? 22.18590  -6.27697  -10.85353 1.000 42.86000  ? 396 MET B N   1 
ATOM   4081 C CA  . MET B 1 278 ? 20.97986  -5.46095  -11.01012 1.000 33.68000  ? 396 MET B CA  1 
ATOM   4082 C C   . MET B 1 278 ? 21.01930  -4.23783  -10.09330 1.000 40.29000  ? 396 MET B C   1 
ATOM   4083 O O   . MET B 1 278 ? 20.71215  -3.11788  -10.51331 1.000 40.75000  ? 396 MET B O   1 
ATOM   4084 C CB  . MET B 1 278 ? 19.74598  -6.29287  -10.67447 1.000 39.27000  ? 396 MET B CB  1 
ATOM   4085 C CG  . MET B 1 278 ? 19.40957  -7.50698  -11.52616 1.000 43.70000  ? 396 MET B CG  1 
ATOM   4086 S SD  . MET B 1 278 ? 18.87486  -7.13218  -13.17297 1.000 61.91000  ? 396 MET B SD  1 
ATOM   4087 C CE  . MET B 1 278 ? 17.27402  -6.44409  -12.86637 1.000 46.58000  ? 396 MET B CE  1 
ATOM   4088 N N   . LEU B 1 279 ? 21.34985  -4.43967  -8.81341  1.000 37.11000  ? 397 LEU B N   1 
ATOM   4089 C CA  . LEU B 1 279 ? 21.40528  -3.30555  -7.89659  1.000 39.95000  ? 397 LEU B CA  1 
ATOM   4090 C C   . LEU B 1 279 ? 22.48514  -2.30664  -8.30520  1.000 42.16000  ? 397 LEU B C   1 
ATOM   4091 O O   . LEU B 1 279 ? 22.26920  -1.09062  -8.23426  1.000 46.91000  ? 397 LEU B O   1 
ATOM   4092 C CB  . LEU B 1 279 ? 21.64489  -3.78937  -6.47063  1.000 40.14000  ? 397 LEU B CB  1 
ATOM   4093 C CG  . LEU B 1 279 ? 20.44518  -4.42124  -5.77402  1.000 39.75000  ? 397 LEU B CG  1 
ATOM   4094 C CD1 . LEU B 1 279 ? 20.83678  -4.75806  -4.36915  1.000 37.67000  ? 397 LEU B CD1 1 
ATOM   4095 C CD2 . LEU B 1 279 ? 19.27020  -3.46720  -5.78164  1.000 31.54000  ? 397 LEU B CD2 1 
ATOM   4096 N N   . THR B 1 280 ? 23.65394  -2.79673  -8.73064  1.000 41.70000  ? 398 THR B N   1 
ATOM   4097 C CA  . THR B 1 280 ? 24.69074  -1.89783  -9.23321  1.000 43.53000  ? 398 THR B CA  1 
ATOM   4098 C C   . THR B 1 280 ? 24.21322  -1.17398  -10.48510 1.000 41.10000  ? 398 THR B C   1 
ATOM   4099 O O   . THR B 1 280 ? 24.53016  0.00398   -10.70040 1.000 43.02000  ? 398 THR B O   1 
ATOM   4100 C CB  . THR B 1 280 ? 25.98059  -2.67491  -9.51867  1.000 43.46000  ? 398 THR B CB  1 
ATOM   4101 O OG1 . THR B 1 280 ? 26.49011  -3.22276  -8.29882  1.000 53.42000  ? 398 THR B OG1 1 
ATOM   4102 C CG2 . THR B 1 280 ? 27.02637  -1.76001  -10.08725 1.000 36.63000  ? 398 THR B CG2 1 
ATOM   4103 N N   . GLU B 1 281 ? 23.44083  -1.86507  -11.31867 1.000 41.10000  ? 399 GLU B N   1 
ATOM   4104 C CA  . GLU B 1 281 ? 22.84234  -1.22421  -12.48450 1.000 42.82000  ? 399 GLU B CA  1 
ATOM   4105 C C   . GLU B 1 281 ? 21.83056  -0.17012  -12.05220 1.000 45.44000  ? 399 GLU B C   1 
ATOM   4106 O O   . GLU B 1 281 ? 21.89241  0.98282   -12.48738 1.000 49.66000  ? 399 GLU B O   1 
ATOM   4107 C CB  . GLU B 1 281 ? 22.21292  -2.30431  -13.37808 1.000 44.15000  ? 399 GLU B CB  1 
ATOM   4108 C CG  . GLU B 1 281 ? 21.33244  -1.84943  -14.50675 1.000 54.34000  ? 399 GLU B CG  1 
ATOM   4109 C CD  . GLU B 1 281 ? 22.11697  -1.22161  -15.64218 1.000 67.85000  ? 399 GLU B CD  1 
ATOM   4110 O OE1 . GLU B 1 281 ? 21.56448  -1.08774  -16.76596 1.000 70.56000  ? 399 GLU B OE1 1 
ATOM   4111 O OE2 . GLU B 1 281 ? 23.27808  -0.83161  -15.40074 1.000 59.34000  ? 399 GLU B OE2 1 
ATOM   4112 N N   . LEU B 1 282 ? 20.92795  -0.53597  -11.14175 1.000 43.55000  ? 400 LEU B N   1 
ATOM   4113 C CA  . LEU B 1 282 ? 19.90117  0.39212   -10.69643 1.000 44.30000  ? 400 LEU B CA  1 
ATOM   4114 C C   . LEU B 1 282 ? 20.51246  1.66518   -10.13186 1.000 45.30000  ? 400 LEU B C   1 
ATOM   4115 O O   . LEU B 1 282 ? 19.96441  2.75817   -10.32077 1.000 44.78000  ? 400 LEU B O   1 
ATOM   4116 C CB  . LEU B 1 282 ? 19.01161  -0.30071  -9.65795  1.000 47.87000  ? 400 LEU B CB  1 
ATOM   4117 C CG  . LEU B 1 282 ? 17.80488  0.42740   -9.07052  1.000 41.05000  ? 400 LEU B CG  1 
ATOM   4118 C CD1 . LEU B 1 282 ? 16.90739  0.82427   -10.21918 1.000 39.45000  ? 400 LEU B CD1 1 
ATOM   4119 C CD2 . LEU B 1 282 ? 17.06129  -0.47645  -8.08607  1.000 27.81000  ? 400 LEU B CD2 1 
ATOM   4120 N N   . ARG B 1 283 ? 21.65275  1.55723   -9.45235  1.000 45.49000  ? 401 ARG B N   1 
ATOM   4121 C CA  . ARG B 1 283 ? 22.25105  2.74929   -8.85677  1.000 45.35000  ? 401 ARG B CA  1 
ATOM   4122 C C   . ARG B 1 283 ? 22.70361  3.72814   -9.93110  1.000 47.87000  ? 401 ARG B C   1 
ATOM   4123 O O   . ARG B 1 283 ? 22.58972  4.94616   -9.76321  1.000 45.55000  ? 401 ARG B O   1 
ATOM   4124 C CB  . ARG B 1 283 ? 23.41443  2.34938   -7.96422  1.000 48.13000  ? 401 ARG B CB  1 
ATOM   4125 C CG  . ARG B 1 283 ? 24.02979  3.49546   -7.21964  1.000 48.04000  ? 401 ARG B CG  1 
ATOM   4126 C CD  . ARG B 1 283 ? 25.36803  3.07950   -6.63717  1.000 57.49000  ? 401 ARG B CD  1 
ATOM   4127 N NE  . ARG B 1 283 ? 25.93241  4.15459   -5.82756  1.000 71.81000  ? 401 ARG B NE  1 
ATOM   4128 C CZ  . ARG B 1 283 ? 26.16599  4.08376   -4.51466  1.000 70.77000  ? 401 ARG B CZ  1 
ATOM   4129 N NH1 . ARG B 1 283 ? 25.88825  2.97386   -3.82439  1.000 62.69000  ? 401 ARG B NH1 1 
ATOM   4130 N NH2 . ARG B 1 283 ? 26.66829  5.13982   -3.88502  1.000 66.07000  ? 401 ARG B NH2 1 
ATOM   4131 N N   . SER B 1 284 ? 23.18510  3.21197   -11.06124 1.000 50.83000  ? 402 SER B N   1 
ATOM   4132 C CA  . SER B 1 284 ? 23.57765  4.08181   -12.16353 1.000 45.51000  ? 402 SER B CA  1 
ATOM   4133 C C   . SER B 1 284 ? 22.36039  4.74876   -12.80508 1.000 47.25000  ? 402 SER B C   1 
ATOM   4134 O O   . SER B 1 284 ? 22.34734  5.96974   -12.99624 1.000 43.68000  ? 402 SER B O   1 
ATOM   4135 C CB  . SER B 1 284 ? 24.38418  3.27165   -13.17577 1.000 41.44000  ? 402 SER B CB  1 
ATOM   4136 O OG  . SER B 1 284 ? 24.49566  3.94849   -14.40491 1.000 55.31000  ? 402 SER B OG  1 
ATOM   4137 N N   . ILE B 1 285 ? 21.32422  3.95875   -13.12953 1.000 42.57000  ? 403 ILE B N   1 
ATOM   4138 C CA  . ILE B 1 285 ? 20.07399  4.48371   -13.69705 1.000 41.62000  ? 403 ILE B CA  1 
ATOM   4139 C C   . ILE B 1 285 ? 19.48140  5.59285   -12.82594 1.000 43.93000  ? 403 ILE B C   1 
ATOM   4140 O O   . ILE B 1 285 ? 18.98221  6.60380   -13.33386 1.000 43.36000  ? 403 ILE B O   1 
ATOM   4141 C CB  . ILE B 1 285 ? 19.06187  3.33772   -13.87946 1.000 43.03000  ? 403 ILE B CB  1 
ATOM   4142 C CG1 . ILE B 1 285 ? 19.57941  2.30057   -14.86454 1.000 42.43000  ? 403 ILE B CG1 1 
ATOM   4143 C CG2 . ILE B 1 285 ? 17.71770  3.87770   -14.32494 1.000 42.96000  ? 403 ILE B CG2 1 
ATOM   4144 C CD1 . ILE B 1 285 ? 18.87141  0.99561   -14.77206 1.000 46.08000  ? 403 ILE B CD1 1 
ATOM   4145 N N   . ASN B 1 286 ? 19.47797  5.38902   -11.50491 1.000 43.16000  ? 404 ASN B N   1 
ATOM   4146 C CA  . ASN B 1 286 ? 19.13442  6.44016   -10.54790 1.000 44.43000  ? 404 ASN B CA  1 
ATOM   4147 C C   . ASN B 1 286 ? 19.82232  7.77410   -10.87638 1.000 45.60000  ? 404 ASN B C   1 
ATOM   4148 O O   . ASN B 1 286 ? 19.17331  8.82211   -10.96224 1.000 47.97000  ? 404 ASN B O   1 
ATOM   4149 C CB  . ASN B 1 286 ? 19.52702  5.94734   -9.15201  1.000 45.84000  ? 404 ASN B CB  1 
ATOM   4150 C CG  . ASN B 1 286 ? 19.02653  6.83450   -8.03491  1.000 42.71000  ? 404 ASN B CG  1 
ATOM   4151 O OD1 . ASN B 1 286 ? 18.34047  7.84149   -8.25574  1.000 47.41000  ? 404 ASN B OD1 1 
ATOM   4152 N ND2 . ASN B 1 286 ? 19.37706  6.45966   -6.80801  1.000 40.60000  ? 404 ASN B ND2 1 
ATOM   4153 N N   . ALA B 1 287 ? 21.14224  7.75003   -11.06395 1.000 46.43000  ? 405 ALA B N   1 
ATOM   4154 C CA  . ALA B 1 287 ? 21.86613  8.97697   -11.38643 1.000 45.62000  ? 405 ALA B CA  1 
ATOM   4155 C C   . ALA B 1 287 ? 21.37358  9.59581   -12.68930 1.000 41.20000  ? 405 ALA B C   1 
ATOM   4156 O O   . ALA B 1 287 ? 21.13459  10.80081  -12.76036 1.000 47.60000  ? 405 ALA B O   1 
ATOM   4157 C CB  . ALA B 1 287 ? 23.37209  8.69991   -11.45805 1.000 39.34000  ? 405 ALA B CB  1 
ATOM   4158 N N   . GLN B 1 288 ? 21.22510  8.79167   -13.74013 1.000 45.78000  ? 406 GLN B N   1 
ATOM   4159 C CA  . GLN B 1 288 ? 20.81856  9.36451   -15.01703 1.000 46.26000  ? 406 GLN B CA  1 
ATOM   4160 C C   . GLN B 1 288 ? 19.40961  9.94057   -14.93649 1.000 50.42000  ? 406 GLN B C   1 
ATOM   4161 O O   . GLN B 1 288 ? 19.13239  10.99450  -15.51751 1.000 52.20000  ? 406 GLN B O   1 
ATOM   4162 C CB  . GLN B 1 288 ? 20.92204  8.32936   -16.13793 1.000 37.02000  ? 406 GLN B CB  1 
ATOM   4163 C CG  . GLN B 1 288 ? 20.33847  8.82220   -17.47975 1.000 59.81000  ? 406 GLN B CG  1 
ATOM   4164 N N   . HIS B 1 289 ? 18.50691  9.28269   -14.20701 1.000 53.53000  ? 407 HIS B N   1 
ATOM   4165 C CA  . HIS B 1 289 ? 17.15497  9.82375   -14.11749 1.000 49.83000  ? 407 HIS B CA  1 
ATOM   4166 C C   . HIS B 1 289 ? 17.07841  11.01987  -13.19062 1.000 49.46000  ? 407 HIS B C   1 
ATOM   4167 O O   . HIS B 1 289 ? 16.21735  11.88087  -13.38435 1.000 53.60000  ? 407 HIS B O   1 
ATOM   4168 C CB  . HIS B 1 289 ? 16.16612  8.74483   -13.68391 1.000 50.72000  ? 407 HIS B CB  1 
ATOM   4169 C CG  . HIS B 1 289 ? 15.67660  7.90970   -14.82659 1.000 53.70000  ? 407 HIS B CG  1 
ATOM   4170 N ND1 . HIS B 1 289 ? 14.33648  7.71270   -15.08998 1.000 51.66000  ? 407 HIS B ND1 1 
ATOM   4171 C CD2 . HIS B 1 289 ? 16.35316  7.24555   -15.79379 1.000 47.24000  ? 407 HIS B CD2 1 
ATOM   4172 C CE1 . HIS B 1 289 ? 14.21099  6.95456   -16.16482 1.000 55.24000  ? 407 HIS B CE1 1 
ATOM   4173 N NE2 . HIS B 1 289 ? 15.41878  6.65247   -16.60731 1.000 56.34000  ? 407 HIS B NE2 1 
ATOM   4174 N N   . THR B 1 290 ? 17.98283  11.09697  -12.23102 1.000 45.60000  ? 408 THR B N   1 
ATOM   4175 C CA  . THR B 1 290 ? 18.00824  12.28909  -11.36219 1.000 52.66000  ? 408 THR B CA  1 
ATOM   4176 C C   . THR B 1 290 ? 18.50391  13.45496  -12.21056 1.000 53.28000  ? 408 THR B C   1 
ATOM   4177 O O   . THR B 1 290 ? 18.13206  14.57801  -11.94355 1.000 56.80000  ? 408 THR B O   1 
ATOM   4178 C CB  . THR B 1 290 ? 18.95975  12.09322  -10.18458 1.000 55.30000  ? 408 THR B CB  1 
ATOM   4179 O OG1 . THR B 1 290 ? 18.37012  11.17336  -9.27720  1.000 56.15000  ? 408 THR B OG1 1 
ATOM   4180 C CG2 . THR B 1 290 ? 19.25411  13.38230  -9.46088  1.000 53.00000  ? 408 THR B CG2 1 
ATOM   4181 N N   . GLN B 1 291 ? 19.32847  13.15880  -13.20488 1.000 56.69000  ? 409 GLN B N   1 
ATOM   4182 C CA  . GLN B 1 291 ? 19.88610  14.18966  -14.10926 1.000 55.53000  ? 409 GLN B CA  1 
ATOM   4183 C C   . GLN B 1 291 ? 18.78470  14.63657  -15.06784 1.000 57.12000  ? 409 GLN B C   1 
ATOM   4184 O O   . GLN B 1 291 ? 18.72960  15.80653  -15.37698 1.000 64.89000  ? 409 GLN B O   1 
ATOM   4185 C CB  . GLN B 1 291 ? 21.12477  13.64953  -14.82373 1.000 54.39000  ? 409 GLN B CB  1 
ATOM   4186 C CG  . GLN B 1 291 ? 22.43507  14.07058  -14.17936 1.000 53.84000  ? 409 GLN B CG  1 
ATOM   4187 N N   . ARG B 1 292 ? 17.93548  13.71754  -15.50435 1.000 46.29000  ? 410 ARG B N   1 
ATOM   4188 C CA  . ARG B 1 292 ? 16.81710  14.06645  -16.40291 1.000 52.72000  ? 410 ARG B CA  1 
ATOM   4189 C C   . ARG B 1 292 ? 15.83546  14.94658  -15.63760 1.000 55.09000  ? 410 ARG B C   1 
ATOM   4190 O O   . ARG B 1 292 ? 15.30424  15.87152  -16.21249 1.000 54.33000  ? 410 ARG B O   1 
ATOM   4191 C CB  . ARG B 1 292 ? 16.05089  12.80242  -16.78941 1.000 53.81000  ? 410 ARG B CB  1 
ATOM   4192 C CG  . ARG B 1 292 ? 16.76845  11.86427  -17.74259 1.000 52.21000  ? 410 ARG B CG  1 
ATOM   4193 C CD  . ARG B 1 292 ? 15.86927  10.69626  -18.05404 1.000 59.08000  ? 410 ARG B CD  1 
ATOM   4194 N NE  . ARG B 1 292 ? 16.55400  9.54317   -18.60019 1.000 60.61000  ? 410 ARG B NE  1 
ATOM   4195 C CZ  . ARG B 1 292 ? 16.06756  8.77305   -19.55287 1.000 59.62000  ? 410 ARG B CZ  1 
ATOM   4196 N NH1 . ARG B 1 292 ? 14.88834  9.03602   -20.07140 1.000 64.85000  ? 410 ARG B NH1 1 
ATOM   4197 N NH2 . ARG B 1 292 ? 16.75134  7.74097   -19.99204 1.000 55.28000  ? 410 ARG B NH2 1 
ATOM   4198 N N   . LEU B 1 293 ? 15.59700  14.62776  -14.37545 1.000 54.51000  ? 411 LEU B N   1 
ATOM   4199 C CA  . LEU B 1 293 ? 14.64538  15.38090  -13.56814 1.000 52.72000  ? 411 LEU B CA  1 
ATOM   4200 C C   . LEU B 1 293 ? 15.05648  16.83490  -13.43451 1.000 59.46000  ? 411 LEU B C   1 
ATOM   4201 O O   . LEU B 1 293 ? 14.20349  17.73092  -13.46826 1.000 64.56000  ? 411 LEU B O   1 
ATOM   4202 C CB  . LEU B 1 293 ? 14.51296  14.74208  -12.19199 1.000 47.47000  ? 411 LEU B CB  1 
ATOM   4203 C CG  . LEU B 1 293 ? 13.60939  15.51724  -11.24970 1.000 47.73000  ? 411 LEU B CG  1 
ATOM   4204 C CD1 . LEU B 1 293 ? 12.19518  15.46921  -11.73808 1.000 53.83000  ? 411 LEU B CD1 1 
ATOM   4205 C CD2 . LEU B 1 293 ? 13.71599  14.95042  -9.84667  1.000 47.68000  ? 411 LEU B CD2 1 
ATOM   4206 N N   . LEU B 1 294 ? 16.35856  17.08688  -13.27411 1.000 58.13000  ? 412 LEU B N   1 
ATOM   4207 C CA  . LEU B 1 294 ? 16.85765  18.45188  -13.16151 1.000 61.39000  ? 412 LEU B CA  1 
ATOM   4208 C C   . LEU B 1 294 ? 16.79109  19.20371  -14.48458 1.000 62.43000  ? 412 LEU B C   1 
ATOM   4209 O O   . LEU B 1 294 ? 16.42312  20.38572  -14.50058 1.000 59.89000  ? 412 LEU B O   1 
ATOM   4210 C CB  . LEU B 1 294 ? 18.26390  18.41492  -12.57312 1.000 58.41000  ? 412 LEU B CB  1 
ATOM   4211 C CG  . LEU B 1 294 ? 18.25857  18.37712  -11.03811 1.000 65.82000  ? 412 LEU B CG  1 
ATOM   4212 C CD1 . LEU B 1 294 ? 17.66382  17.12423  -10.37069 1.000 69.45000  ? 412 LEU B CD1 1 
ATOM   4213 C CD2 . LEU B 1 294 ? 19.73674  18.49413  -10.66377 1.000 62.04000  ? 412 LEU B CD2 1 
ATOM   4214 N N   . ARG B 1 295 ? 17.11458  18.54555  -15.60564 1.000 53.29000  ? 413 ARG B N   1 
ATOM   4215 C CA  . ARG B 1 295 ? 16.93604  19.20438  -16.89765 1.000 57.05000  ? 413 ARG B CA  1 
ATOM   4216 C C   . ARG B 1 295 ? 15.48797  19.63040  -17.09207 1.000 65.42000  ? 413 ARG B C   1 
ATOM   4217 O O   . ARG B 1 295 ? 15.20884  20.78036  -17.45710 1.000 70.23000  ? 413 ARG B O   1 
ATOM   4218 C CB  . ARG B 1 295 ? 17.36951  18.29722  -18.04072 1.000 55.58000  ? 413 ARG B CB  1 
ATOM   4219 C CG  . ARG B 1 295 ? 18.80852  17.89418  -17.99429 1.000 56.76000  ? 413 ARG B CG  1 
ATOM   4220 C CD  . ARG B 1 295 ? 19.24891  17.38198  -19.35041 1.000 60.67000  ? 413 ARG B CD  1 
ATOM   4221 N NE  . ARG B 1 295 ? 19.18383  15.92698  -19.42919 1.000 66.30000  ? 413 ARG B NE  1 
ATOM   4222 C CZ  . ARG B 1 295 ? 20.09803  15.10302  -18.92148 1.000 65.60000  ? 413 ARG B CZ  1 
ATOM   4223 N NH1 . ARG B 1 295 ? 21.15533  15.58507  -18.27201 1.000 63.09000  ? 413 ARG B NH1 1 
ATOM   4224 N NH2 . ARG B 1 295 ? 19.94393  13.79300  -19.05624 1.000 62.60000  ? 413 ARG B NH2 1 
ATOM   4225 N N   . ILE B 1 296 ? 14.55305  18.71146  -16.83354 1.000 60.08000  ? 414 ILE B N   1 
ATOM   4226 C CA  . ILE B 1 296 ? 13.13398  19.01048  -17.00996 1.000 59.83000  ? 414 ILE B CA  1 
ATOM   4227 C C   . ILE B 1 296 ? 12.71242  20.14862  -16.08793 1.000 61.03000  ? 414 ILE B C   1 
ATOM   4228 O O   . ILE B 1 296 ? 12.07526  21.11558  -16.51678 1.000 65.07000  ? 414 ILE B O   1 
ATOM   4229 C CB  . ILE B 1 296 ? 12.29205  17.74854  -16.75843 1.000 59.75000  ? 414 ILE B CB  1 
ATOM   4230 C CG1 . ILE B 1 296 ? 12.73563  16.62041  -17.66147 1.000 56.78000  ? 414 ILE B CG1 1 
ATOM   4231 C CG2 . ILE B 1 296 ? 10.83194  18.00855  -17.03282 1.000 56.64000  ? 414 ILE B CG2 1 
ATOM   4232 C CD1 . ILE B 1 296 ? 11.97970  15.36347  -17.39397 1.000 62.37000  ? 414 ILE B CD1 1 
ATOM   4233 N N   . GLN B 1 297 ? 13.04498  20.03778  -14.79806 1.000 62.26000  ? 415 GLN B N   1 
ATOM   4234 C CA  . GLN B 1 297 ? 12.65443  21.05992  -13.83103 1.000 65.69000  ? 415 GLN B CA  1 
ATOM   4235 C C   . GLN B 1 297 ? 13.15729  22.43685  -14.25243 1.000 64.51000  ? 415 GLN B C   1 
ATOM   4236 O O   . GLN B 1 297 ? 12.49843  23.44790  -13.99328 1.000 61.27000  ? 415 GLN B O   1 
ATOM   4237 C CB  . GLN B 1 297 ? 13.17603  20.66509  -12.43920 1.000 61.59000  ? 415 GLN B CB  1 
ATOM   4238 C CG  . GLN B 1 297 ? 12.99254  21.70624  -11.34726 1.000 62.40000  ? 415 GLN B CG  1 
ATOM   4239 C CD  . GLN B 1 297 ? 11.64484  21.60838  -10.65666 1.000 69.22000  ? 415 GLN B CD  1 
ATOM   4240 O OE1 . GLN B 1 297 ? 10.75863  20.84435  -11.07717 1.000 62.34000  ? 415 GLN B OE1 1 
ATOM   4241 N NE2 . GLN B 1 297 ? 11.47032  22.40452  -9.60169  1.000 67.08000  ? 415 GLN B NE2 1 
ATOM   4242 N N   . ASP B 1 298 ? 14.31600  22.48173  -14.91594 1.000 72.75000  ? 416 ASP B N   1 
ATOM   4243 C CA  . ASP B 1 298 ? 14.87482  23.72664  -15.43035 1.000 69.03000  ? 416 ASP B CA  1 
ATOM   4244 C C   . ASP B 1 298 ? 13.91741  24.39254  -16.41502 1.000 73.56000  ? 416 ASP B C   1 
ATOM   4245 O O   . ASP B 1 298 ? 13.55151  25.56257  -16.25302 1.000 71.02000  ? 416 ASP B O   1 
ATOM   4246 C CB  . ASP B 1 298 ? 16.21751  23.42551  -16.10190 1.000 69.90000  ? 416 ASP B CB  1 
ATOM   4247 C CG  . ASP B 1 298 ? 17.13153  24.61948  -16.15246 1.000 68.73000  ? 416 ASP B CG  1 
ATOM   4248 O OD1 . ASP B 1 298 ? 16.93390  25.55159  -15.35749 1.000 80.34000  ? 416 ASP B OD1 1 
ATOM   4249 O OD2 . ASP B 1 298 ? 18.03916  24.63333  -17.00585 1.000 70.53000  ? 416 ASP B OD2 1 
ATOM   4250 N N   . ILE B 1 299 ? 13.49494  23.65141  -17.44174 1.000 73.97000  ? 417 ILE B N   1 
ATOM   4251 C CA  . ILE B 1 299 ? 12.59451  24.18031  -18.45742 1.000 64.48000  ? 417 ILE B CA  1 
ATOM   4252 C C   . ILE B 1 299 ? 11.13772  24.21741  -17.97279 1.000 69.72000  ? 417 ILE B C   1 
ATOM   4253 O O   . ILE B 1 299 ? 10.34053  25.01937  -18.47554 1.000 73.40000  ? 417 ILE B O   1 
ATOM   4254 C CB  . ILE B 1 299 ? 12.73592  23.35413  -19.75137 1.000 69.75000  ? 417 ILE B CB  1 
ATOM   4255 N N   . HIS B 1 300 ? 10.75111  23.37155  -17.01750 1.000 68.95000  ? 418 HIS B N   1 
ATOM   4256 C CA  . HIS B 1 300 ? 9.34328   23.24565  -16.62387 1.000 73.63000  ? 418 HIS B CA  1 
ATOM   4257 C C   . HIS B 1 300 ? 9.25990   22.78884  -15.17577 1.000 71.42000  ? 418 HIS B C   1 
ATOM   4258 O O   . HIS B 1 300 ? 9.15699   21.58889  -14.88757 1.000 72.28000  ? 418 HIS B O   1 
ATOM   4259 C CB  . HIS B 1 300 ? 8.58385   22.28455  -17.54241 1.000 68.27000  ? 418 HIS B CB  1 
ATOM   4260 C CG  . HIS B 1 300 ? 7.11097   22.20163  -17.26676 1.000 66.93000  ? 418 HIS B CG  1 
ATOM   4261 N ND1 . HIS B 1 300 ? 6.16561   22.72355  -18.12042 1.000 69.83000  ? 418 HIS B ND1 1 
ATOM   4262 C CD2 . HIS B 1 300 ? 6.41939   21.61779  -16.25738 1.000 76.52000  ? 418 HIS B CD2 1 
ATOM   4263 C CE1 . HIS B 1 300 ? 4.95581   22.49165  -17.63886 1.000 72.74000  ? 418 HIS B CE1 1 
ATOM   4264 N NE2 . HIS B 1 300 ? 5.08029   21.81979  -16.50882 1.000 76.96000  ? 418 HIS B NE2 1 
ATOM   4265 N N   . PRO B 1 301 ? 9.28734   23.72497  -14.23191 1.000 70.21000  ? 419 PRO B N   1 
ATOM   4266 C CA  . PRO B 1 301 ? 9.22995   23.35116  -12.81184 1.000 73.99000  ? 419 PRO B CA  1 
ATOM   4267 C C   . PRO B 1 301 ? 7.94907   22.59924  -12.47918 1.000 72.48000  ? 419 PRO B C   1 
ATOM   4268 O O   . PRO B 1 301 ? 6.84695   23.06624  -12.77376 1.000 78.81000  ? 419 PRO B O   1 
ATOM   4269 C CB  . PRO B 1 301 ? 9.28530   24.70526  -12.09604 1.000 70.63000  ? 419 PRO B CB  1 
ATOM   4270 C CG  . PRO B 1 301 ? 10.03492  25.57211  -13.02448 1.000 70.17000  ? 419 PRO B CG  1 
ATOM   4271 C CD  . PRO B 1 301 ? 9.59331   25.14994  -14.40724 1.000 72.19000  ? 419 PRO B CD  1 
ATOM   4272 N N   . PHE B 1 302 ? 8.09831   21.43233  -11.84109 1.000 72.83000  ? 420 PHE B N   1 
ATOM   4273 C CA  . PHE B 1 302 ? 6.92844   20.62641  -11.49047 1.000 70.88000  ? 420 PHE B CA  1 
ATOM   4274 C C   . PHE B 1 302 ? 7.13596   19.75957  -10.24944 1.000 63.40000  ? 420 PHE B C   1 
ATOM   4275 O O   . PHE B 1 302 ? 6.18815   19.14266  -9.75395  1.000 58.91000  ? 420 PHE B O   1 
ATOM   4276 C CB  . PHE B 1 302 ? 6.54190   19.72126  -12.65818 1.000 65.69000  ? 420 PHE B CB  1 
ATOM   4277 C CG  . PHE B 1 302 ? 7.45480   18.54621  -12.81942 1.000 60.48000  ? 420 PHE B CG  1 
ATOM   4278 C CD1 . PHE B 1 302 ? 8.68753   18.69109  -13.43298 1.000 58.68000  ? 420 PHE B CD1 1 
ATOM   4279 C CD2 . PHE B 1 302 ? 7.09798   17.30829  -12.32210 1.000 57.40000  ? 420 PHE B CD2 1 
ATOM   4280 C CE1 . PHE B 1 302 ? 9.53344   17.62005  -13.57420 1.000 59.71000  ? 420 PHE B CE1 1 
ATOM   4281 C CE2 . PHE B 1 302 ? 7.94889   16.23525  -12.44433 1.000 60.33000  ? 420 PHE B CE2 1 
ATOM   4282 C CZ  . PHE B 1 302 ? 9.16662   16.38613  -13.07488 1.000 60.04000  ? 420 PHE B CZ  1 
ATOM   4283 N N   . ALA B 1 303 ? 8.36217   19.67660  -9.74997  1.000 60.93000  ? 421 ALA B N   1 
ATOM   4284 C CA  . ALA B 1 303 ? 8.63062   18.74973  -8.65996  1.000 50.87000  ? 421 ALA B CA  1 
ATOM   4285 C C   . ALA B 1 303 ? 7.89119   19.16393  -7.38969  1.000 52.95000  ? 421 ALA B C   1 
ATOM   4286 O O   . ALA B 1 303 ? 7.72735   20.34997  -7.09778  1.000 62.56000  ? 421 ALA B O   1 
ATOM   4287 C CB  . ALA B 1 303 ? 10.13373  18.66572  -8.40160  1.000 45.74000  ? 421 ALA B CB  1 
ATOM   4288 N N   . THR B 1 304 ? 7.43349   18.17604  -6.63236  1.000 55.98000  ? 422 THR B N   1 
ATOM   4289 C CA  . THR B 1 304 ? 6.83006   18.45723  -5.34613  1.000 49.29000  ? 422 THR B CA  1 
ATOM   4290 C C   . THR B 1 304 ? 7.91151   18.84533  -4.34166  1.000 52.75000  ? 422 THR B C   1 
ATOM   4291 O O   . THR B 1 304 ? 9.09141   18.54527  -4.53913  1.000 53.81000  ? 422 THR B O   1 
ATOM   4292 C CB  . THR B 1 304 ? 6.04924   17.24532  -4.85163  1.000 49.90000  ? 422 THR B CB  1 
ATOM   4293 O OG1 . THR B 1 304 ? 6.95031   16.15533  -4.61288  1.000 50.11000  ? 422 THR B OG1 1 
ATOM   4294 C CG2 . THR B 1 304 ? 5.00477   16.85021  -5.88912  1.000 44.81000  ? 422 THR B CG2 1 
ATOM   4295 N N   . PRO B 1 305 ? 7.53999   19.56549  -3.27659  1.000 58.38000  ? 423 PRO B N   1 
ATOM   4296 C CA  . PRO B 1 305 ? 8.53945   19.89859  -2.24907  1.000 52.26000  ? 423 PRO B CA  1 
ATOM   4297 C C   . PRO B 1 305 ? 9.31763   18.68063  -1.76725  1.000 54.34000  ? 423 PRO B C   1 
ATOM   4298 O O   . PRO B 1 305 ? 10.53871  18.76162  -1.57379  1.000 56.50000  ? 423 PRO B O   1 
ATOM   4299 C CB  . PRO B 1 305 ? 7.68496   20.51277  -1.13178  1.000 51.82000  ? 423 PRO B CB  1 
ATOM   4300 C CG  . PRO B 1 305 ? 6.47667   21.04671  -1.83933  1.000 43.27000  ? 423 PRO B CG  1 
ATOM   4301 C CD  . PRO B 1 305 ? 6.20315   20.10957  -2.95308  1.000 49.63000  ? 423 PRO B CD  1 
ATOM   4302 N N   . LEU B 1 306 ? 8.64767   17.53768  -1.58680  1.000 49.10000  ? 424 LEU B N   1 
ATOM   4303 C CA  . LEU B 1 306 ? 9.37082   16.33971  -1.16496  1.000 52.65000  ? 424 LEU B CA  1 
ATOM   4304 C C   . LEU B 1 306 ? 10.36534  15.87054  -2.23533  1.000 54.38000  ? 424 LEU B C   1 
ATOM   4305 O O   . LEU B 1 306 ? 11.48347  15.44755  -1.91076  1.000 55.41000  ? 424 LEU B O   1 
ATOM   4306 C CB  . LEU B 1 306 ? 8.38294   15.22879  -0.82038  1.000 56.19000  ? 424 LEU B CB  1 
ATOM   4307 C CG  . LEU B 1 306 ? 8.99319   13.99686  -0.14748  1.000 50.21000  ? 424 LEU B CG  1 
ATOM   4308 C CD1 . LEU B 1 306 ? 9.77175   14.39501  1.11012   1.000 53.20000  ? 424 LEU B CD1 1 
ATOM   4309 C CD2 . LEU B 1 306 ? 7.91729   12.97693  0.15412   1.000 42.94000  ? 424 LEU B CD2 1 
ATOM   4310 N N   . MET B 1 307 ? 9.98178   15.93538  -3.51417  1.000 49.61000  ? 425 MET B N   1 
ATOM   4311 C CA  . MET B 1 307 ? 10.92431  15.59421  -4.56954  1.000 48.01000  ? 425 MET B CA  1 
ATOM   4312 C C   . MET B 1 307 ? 12.09233  16.56617  -4.59318  1.000 47.12000  ? 425 MET B C   1 
ATOM   4313 O O   . MET B 1 307 ? 13.21717  16.18209  -4.93362  1.000 50.33000  ? 425 MET B O   1 
ATOM   4314 C CB  . MET B 1 307 ? 10.22572  15.58405  -5.92823  1.000 50.50000  ? 425 MET B CB  1 
ATOM   4315 C CG  . MET B 1 307 ? 9.11263   14.55607  -6.04361  1.000 49.14000  ? 425 MET B CG  1 
ATOM   4316 S SD  . MET B 1 307 ? 8.34892   14.44987  -7.68226  1.000 48.93000  ? 425 MET B SD  1 
ATOM   4317 C CE  . MET B 1 307 ? 9.69447   14.93869  -8.74692  1.000 47.95000  ? 425 MET B CE  1 
ATOM   4318 N N   . GLN B 1 308 ? 11.84952  17.82323  -4.23624  1.000 49.13000  ? 426 GLN B N   1 
ATOM   4319 C CA  . GLN B 1 308 ? 12.93055  18.79919  -4.25284  1.000 51.30000  ? 426 GLN B CA  1 
ATOM   4320 C C   . GLN B 1 308 ? 13.96500  18.48230  -3.18525  1.000 47.18000  ? 426 GLN B C   1 
ATOM   4321 O O   . GLN B 1 308 ? 15.17090  18.60124  -3.42579  1.000 50.58000  ? 426 GLN B O   1 
ATOM   4322 C CB  . GLN B 1 308 ? 12.36867  20.20823  -4.07079  1.000 61.49000  ? 426 GLN B CB  1 
ATOM   4323 C CG  . GLN B 1 308 ? 12.01412  20.92607  -5.37973  1.000 67.02000  ? 426 GLN B CG  1 
ATOM   4324 C CD  . GLN B 1 308 ? 11.26426  22.23112  -5.14857  1.000 68.16000  ? 426 GLN B CD  1 
ATOM   4325 O OE1 . GLN B 1 308 ? 10.60671  22.40628  -4.12631  1.000 66.27000  ? 426 GLN B OE1 1 
ATOM   4326 N NE2 . GLN B 1 308 ? 11.40388  23.17099  -6.08076  1.000 77.27000  ? 426 GLN B NE2 1 
ATOM   4327 N N   . GLU B 1 309 ? 13.51950  18.04047  -2.01200  1.000 48.53000  ? 427 GLU B N   1 
ATOM   4328 C CA  . GLU B 1 309 ? 14.46096  17.70859  -0.94537  1.000 49.10000  ? 427 GLU B CA  1 
ATOM   4329 C C   . GLU B 1 309 ? 15.28076  16.46851  -1.30656  1.000 54.35000  ? 427 GLU B C   1 
ATOM   4330 O O   . GLU B 1 309 ? 16.49786  16.42251  -1.07508  1.000 53.15000  ? 427 GLU B O   1 
ATOM   4331 C CB  . GLU B 1 309 ? 13.69052  17.49679  0.36400   1.000 45.89000  ? 427 GLU B CB  1 
ATOM   4332 C CG  . GLU B 1 309 ? 13.28288  18.78190  1.08601   1.000 56.24000  ? 427 GLU B CG  1 
ATOM   4333 C CD  . GLU B 1 309 ? 12.61947  18.55110  2.45533   1.000 58.48000  ? 427 GLU B CD  1 
ATOM   4334 O OE1 . GLU B 1 309 ? 12.76568  17.45617  3.02841   1.000 58.62000  ? 427 GLU B OE1 1 
ATOM   4335 O OE2 . GLU B 1 309 ? 11.94072  19.47119  2.96050   1.000 58.74000  ? 427 GLU B OE2 1 
ATOM   4336 N N   . LEU B 1 310 ? 14.62847  15.45846  -1.89714  1.000 54.06000  ? 428 LEU B N   1 
ATOM   4337 C CA  . LEU B 1 310 ? 15.28632  14.18140  -2.15625  1.000 48.07000  ? 428 LEU B CA  1 
ATOM   4338 C C   . LEU B 1 310 ? 16.30283  14.28522  -3.28571  1.000 53.78000  ? 428 LEU B C   1 
ATOM   4339 O O   . LEU B 1 310 ? 17.25879  13.49518  -3.33502  1.000 57.30000  ? 428 LEU B O   1 
ATOM   4340 C CB  . LEU B 1 310 ? 14.23715  13.10939  -2.48365  1.000 48.72000  ? 428 LEU B CB  1 
ATOM   4341 C CG  . LEU B 1 310 ? 13.32762  12.60257  -1.35119  1.000 47.78000  ? 428 LEU B CG  1 
ATOM   4342 C CD1 . LEU B 1 310 ? 12.16136  11.84753  -1.91158  1.000 38.96000  ? 428 LEU B CD1 1 
ATOM   4343 C CD2 . LEU B 1 310 ? 14.06804  11.72768  -0.33739  1.000 43.49000  ? 428 LEU B CD2 1 
ATOM   4344 N N   . PHE B 1 311 ? 16.12646  15.24510  -4.19576  1.000 55.99000  ? 429 PHE B N   1 
ATOM   4345 C CA  . PHE B 1 311 ? 16.98896  15.34792  -5.36215  1.000 60.27000  ? 429 PHE B CA  1 
ATOM   4346 C C   . PHE B 1 311 ? 17.82697  16.61989  -5.41569  1.000 60.23000  ? 429 PHE B C   1 
ATOM   4347 O O   . PHE B 1 311 ? 18.60356  16.78374  -6.36405  1.000 72.02000  ? 429 PHE B O   1 
ATOM   4348 C CB  . PHE B 1 311 ? 16.13540  15.19778  -6.62476  1.000 58.57000  ? 429 PHE B CB  1 
ATOM   4349 C CG  . PHE B 1 311 ? 15.42134  13.88179  -6.68227  1.000 57.86000  ? 429 PHE B CG  1 
ATOM   4350 C CD1 . PHE B 1 311 ? 16.13122  12.70175  -6.86843  1.000 55.42000  ? 429 PHE B CD1 1 
ATOM   4351 C CD2 . PHE B 1 311 ? 14.05642  13.80786  -6.49067  1.000 55.06000  ? 429 PHE B CD2 1 
ATOM   4352 C CE1 . PHE B 1 311 ? 15.47717  11.47676  -6.89698  1.000 52.41000  ? 429 PHE B CE1 1 
ATOM   4353 C CE2 . PHE B 1 311 ? 13.39437  12.57688  -6.51221  1.000 50.61000  ? 429 PHE B CE2 1 
ATOM   4354 C CZ  . PHE B 1 311 ? 14.10425  11.41583  -6.70837  1.000 50.23000  ? 429 PHE B CZ  1 
ATOM   4355 N N   . GLY B 1 312 ? 17.72543  17.49902  -4.42476  1.000 60.17000  ? 430 GLY B N   1 
ATOM   4356 C CA  . GLY B 1 312 ? 18.57548  18.67300  -4.38629  1.000 69.69000  ? 430 GLY B CA  1 
ATOM   4357 C C   . GLY B 1 312 ? 18.19707  19.72788  -5.40527  1.000 68.61000  ? 430 GLY B C   1 
ATOM   4358 O O   . GLY B 1 312 ? 18.99170  20.08174  -6.27966  1.000 67.20000  ? 430 GLY B O   1 
ATOM   4359 N N   . ILE B 1 313 ? 16.97713  20.23893  -5.29980  1.000 70.83000  ? 431 ILE B N   1 
ATOM   4360 C CA  . ILE B 1 313 ? 16.46077  21.25783  -6.19971  1.000 71.40000  ? 431 ILE B CA  1 
ATOM   4361 C C   . ILE B 1 313 ? 16.19517  22.51294  -5.37876  1.000 87.78000  ? 431 ILE B C   1 
ATOM   4362 O O   . ILE B 1 313 ? 15.60664  22.43511  -4.29050  1.000 77.21000  ? 431 ILE B O   1 
ATOM   4363 C CB  . ILE B 1 313 ? 15.18744  20.78077  -6.92209  1.000 69.16000  ? 431 ILE B CB  1 
ATOM   4364 C CG1 . ILE B 1 313 ? 15.50100  19.59863  -7.84807  1.000 64.51000  ? 431 ILE B CG1 1 
ATOM   4365 C CG2 . ILE B 1 313 ? 14.55413  21.91468  -7.71597  1.000 74.21000  ? 431 ILE B CG2 1 
ATOM   4366 C CD1 . ILE B 1 313 ? 14.25573  18.92260  -8.41644  1.000 58.14000  ? 431 ILE B CD1 1 
ATOM   4367 N N   . THR B 1 314 ? 16.65298  23.65986  -5.89112  1.000 98.39000  ? 432 THR B N   1 
ATOM   4368 C CA  . THR B 1 314 ? 16.40029  24.96995  -5.27818  1.000 93.79000  ? 432 THR B CA  1 
ATOM   4369 C C   . THR B 1 314 ? 15.75687  25.92484  -6.28603  1.000 88.06000  ? 432 THR B C   1 
ATOM   4370 O O   . THR B 1 314 ? 15.24141  25.49271  -7.32075  1.000 83.65000  ? 432 THR B O   1 
ATOM   4371 C CB  . THR B 1 314 ? 17.70355  25.60898  -4.72484  1.000 93.47000  ? 432 THR B CB  1 
ATOM   4372 O OG1 . THR B 1 314 ? 18.69910  25.67682  -5.76128  1.000 87.44000  ? 432 THR B OG1 1 
ATOM   4373 C CG2 . THR B 1 314 ? 18.23904  24.79913  -3.54096  1.000 86.87000  ? 432 THR B CG2 1 
ATOM   4374 N N   . LEU B 1 328 ? 22.24982  20.29751  7.73089   1.000 93.46000  ? 446 LEU B N   1 
ATOM   4375 C CA  . LEU B 1 328 ? 21.65542  19.26442  6.88529   1.000 89.10000  ? 446 LEU B CA  1 
ATOM   4376 C C   . LEU B 1 328 ? 20.19557  18.96451  7.23796   1.000 84.93000  ? 446 LEU B C   1 
ATOM   4377 O O   . LEU B 1 328 ? 19.42317  18.58941  6.34635   1.000 75.28000  ? 446 LEU B O   1 
ATOM   4378 C CB  . LEU B 1 328 ? 22.51940  18.00440  6.92808   1.000 88.97000  ? 446 LEU B CB  1 
ATOM   4379 C CG  . LEU B 1 328 ? 22.09900  16.79630  6.09842   1.000 74.63000  ? 446 LEU B CG  1 
ATOM   4380 C CD1 . LEU B 1 328 ? 22.02937  17.13410  4.62041   1.000 71.68000  ? 446 LEU B CD1 1 
ATOM   4381 C CD2 . LEU B 1 328 ? 23.16209  15.72330  6.36410   1.000 74.91000  ? 446 LEU B CD2 1 
ATOM   4382 N N   . THR B 1 329 ? 19.77412  19.11869  8.50313   1.000 83.00000  ? 447 THR B N   1 
ATOM   4383 C CA  . THR B 1 329 ? 18.33523  19.01977  8.74677   1.000 79.21000  ? 447 THR B CA  1 
ATOM   4384 C C   . THR B 1 329 ? 17.58209  20.28774  8.34793   1.000 82.08000  ? 447 THR B C   1 
ATOM   4385 O O   . THR B 1 329 ? 16.37098  20.21574  8.10247   1.000 69.44000  ? 447 THR B O   1 
ATOM   4386 C CB  . THR B 1 329 ? 18.01486  18.68897  10.21495  1.000 74.62000  ? 447 THR B CB  1 
ATOM   4387 O OG1 . THR B 1 329 ? 18.39927  19.76708  11.08064  1.000 75.44000  ? 447 THR B OG1 1 
ATOM   4388 C CG2 . THR B 1 329 ? 18.71501  17.42501  10.64282  1.000 79.80000  ? 447 THR B CG2 1 
ATOM   4389 N N   . GLU B 1 330 ? 18.26509  21.43970  8.27048   1.000 85.22000  ? 448 GLU B N   1 
ATOM   4390 C CA  . GLU B 1 330 ? 17.56401  22.69169  7.99462   1.000 81.44000  ? 448 GLU B CA  1 
ATOM   4391 C C   . GLU B 1 330 ? 17.09038  22.75651  6.54581   1.000 86.23000  ? 448 GLU B C   1 
ATOM   4392 O O   . GLU B 1 330 ? 15.99328  23.26151  6.27022   1.000 91.10000  ? 448 GLU B O   1 
ATOM   4393 C CB  . GLU B 1 330 ? 18.45519  23.88971  8.32807   1.000 84.00000  ? 448 GLU B CB  1 
ATOM   4394 N N   . ARG B 1 331 ? 17.88995  22.24136  5.60553   1.000 78.77000  ? 449 ARG B N   1 
ATOM   4395 C CA  . ARG B 1 331 ? 17.50534  22.25318  4.19870   1.000 75.62000  ? 449 ARG B CA  1 
ATOM   4396 C C   . ARG B 1 331 ? 16.60413  21.07616  3.80625   1.000 69.06000  ? 449 ARG B C   1 
ATOM   4397 O O   . ARG B 1 331 ? 16.14163  21.02602  2.66146   1.000 73.50000  ? 449 ARG B O   1 
ATOM   4398 C CB  . ARG B 1 331 ? 18.75996  22.28603  3.32015   1.000 78.62000  ? 449 ARG B CB  1 
ATOM   4399 C CG  . ARG B 1 331 ? 19.78118  23.32206  3.76256   1.000 80.89000  ? 449 ARG B CG  1 
ATOM   4400 C CD  . ARG B 1 331 ? 21.18192  23.08094  3.18598   1.000 88.49000  ? 449 ARG B CD  1 
ATOM   4401 N NE  . ARG B 1 331 ? 21.86713  21.90799  3.73584   1.000 95.94000  ? 449 ARG B NE  1 
ATOM   4402 C CZ  . ARG B 1 331 ? 23.01543  21.95305  4.41733   1.000 101.75000 ? 449 ARG B CZ  1 
ATOM   4403 N NH1 . ARG B 1 331 ? 23.60158  23.12206  4.67992   1.000 97.84000  ? 449 ARG B NH1 1 
ATOM   4404 N NH2 . ARG B 1 331 ? 23.57159  20.83009  4.86324   1.000 96.29000  ? 449 ARG B NH2 1 
ATOM   4405 N N   . HIS B 1 332 ? 16.32450  20.14729  4.71950   1.000 64.78000  ? 450 HIS B N   1 
ATOM   4406 C CA  . HIS B 1 332 ? 15.42335  19.03028  4.44404   1.000 62.15000  ? 450 HIS B CA  1 
ATOM   4407 C C   . HIS B 1 332 ? 14.29180  19.03445  5.47053   1.000 59.32000  ? 450 HIS B C   1 
ATOM   4408 O O   . HIS B 1 332 ? 14.10811  18.08956  6.24674   1.000 55.20000  ? 450 HIS B O   1 
ATOM   4409 C CB  . HIS B 1 332 ? 16.22730  17.72625  4.42086   1.000 60.87000  ? 450 HIS B CB  1 
ATOM   4410 C CG  . HIS B 1 332 ? 17.31085  17.73708  3.38439   1.000 62.44000  ? 450 HIS B CG  1 
ATOM   4411 N ND1 . HIS B 1 332 ? 18.64599  17.88008  3.69879   1.000 69.45000  ? 450 HIS B ND1 1 
ATOM   4412 C CD2 . HIS B 1 332 ? 17.25126  17.66390  2.03442   1.000 54.59000  ? 450 HIS B CD2 1 
ATOM   4413 C CE1 . HIS B 1 332 ? 19.36250  17.88791  2.58747   1.000 57.06000  ? 450 HIS B CE1 1 
ATOM   4414 N NE2 . HIS B 1 332 ? 18.54105  17.75280  1.56485   1.000 53.48000  ? 450 HIS B NE2 1 
ATOM   4415 N N   . LYS B 1 333 ? 13.53082  20.12947  5.45572   1.000 62.86000  ? 451 LYS B N   1 
ATOM   4416 C CA  . LYS B 1 333 ? 12.50127  20.38064  6.45713   1.000 59.84000  ? 451 LYS B CA  1 
ATOM   4417 C C   . LYS B 1 333 ? 11.44024  19.27867  6.45774   1.000 62.08000  ? 451 LYS B C   1 
ATOM   4418 O O   . LYS B 1 333 ? 11.00869  18.82783  7.52899   1.000 56.87000  ? 451 LYS B O   1 
ATOM   4419 C CB  . LYS B 1 333 ? 11.88220  21.76562  6.19422   1.000 63.91000  ? 451 LYS B CB  1 
ATOM   4420 C CG  . LYS B 1 333 ? 10.89967  22.29379  7.23558   1.000 59.92000  ? 451 LYS B CG  1 
ATOM   4421 N N   . ILE B 1 334 ? 11.01770  18.82152  5.26799   1.000 57.37000  ? 452 ILE B N   1 
ATOM   4422 C CA  . ILE B 1 334 ? 9.96164   17.81154  5.18659   1.000 51.84000  ? 452 ILE B CA  1 
ATOM   4423 C C   . ILE B 1 334 ? 10.49279  16.44959  5.63054   1.000 56.26000  ? 452 ILE B C   1 
ATOM   4424 O O   . ILE B 1 334 ? 9.84911   15.73471  6.41491   1.000 52.93000  ? 452 ILE B O   1 
ATOM   4425 C CB  . ILE B 1 334 ? 9.37101   17.74537  3.76185   1.000 58.52000  ? 452 ILE B CB  1 
ATOM   4426 C CG1 . ILE B 1 334 ? 8.91683   19.11832  3.25387   1.000 48.76000  ? 452 ILE B CG1 1 
ATOM   4427 C CG2 . ILE B 1 334 ? 8.18097   16.80740  3.73250   1.000 52.95000  ? 452 ILE B CG2 1 
ATOM   4428 C CD1 . ILE B 1 334 ? 7.84824   19.79347  4.13124   1.000 69.76000  ? 452 ILE B CD1 1 
ATOM   4429 N N   . LEU B 1 335 ? 11.67956  16.07248  5.13207   1.000 56.06000  ? 453 LEU B N   1 
ATOM   4430 C CA  . LEU B 1 335 ? 12.31469  14.81352  5.51996   1.000 45.74000  ? 453 LEU B CA  1 
ATOM   4431 C C   . LEU B 1 335 ? 12.52635  14.73471  7.02588   1.000 54.41000  ? 453 LEU B C   1 
ATOM   4432 O O   . LEU B 1 335 ? 12.17359  13.73281  7.66617   1.000 52.86000  ? 453 LEU B O   1 
ATOM   4433 C CB  . LEU B 1 335 ? 13.65037  14.67038  4.80440   1.000 49.96000  ? 453 LEU B CB  1 
ATOM   4434 C CG  . LEU B 1 335 ? 13.69280  13.81221  3.55449   1.000 52.17000  ? 453 LEU B CG  1 
ATOM   4435 C CD1 . LEU B 1 335 ? 15.09055  13.83809  2.97588   1.000 50.85000  ? 453 LEU B CD1 1 
ATOM   4436 C CD2 . LEU B 1 335 ? 13.27991  12.39427  3.89886   1.000 48.38000  ? 453 LEU B CD2 1 
ATOM   4437 N N   . HIS B 1 336 ? 13.11663  15.78377  7.61048   1.000 52.98000  ? 454 HIS B N   1 
ATOM   4438 C CA  . HIS B 1 336 ? 13.35626  15.78796  9.05037   1.000 51.22000  ? 454 HIS B CA  1 
ATOM   4439 C C   . HIS B 1 336 ? 12.05860  15.58010  9.83397   1.000 53.07000  ? 454 HIS B C   1 
ATOM   4440 O O   . HIS B 1 336 ? 12.03500  14.83123  10.81908  1.000 54.86000  ? 454 HIS B O   1 
ATOM   4441 C CB  . HIS B 1 336 ? 14.05747  17.08499  9.44490   1.000 56.19000  ? 454 HIS B CB  1 
ATOM   4442 C CG  . HIS B 1 336 ? 14.48610  17.14017  10.87770  1.000 61.84000  ? 454 HIS B CG  1 
ATOM   4443 N ND1 . HIS B 1 336 ? 14.10750  18.15929  11.72773  1.000 65.01000  ? 454 HIS B ND1 1 
ATOM   4444 C CD2 . HIS B 1 336 ? 15.25040  16.30024  11.61548  1.000 66.38000  ? 454 HIS B CD2 1 
ATOM   4445 C CE1 . HIS B 1 336 ? 14.63102  17.95144  12.92353  1.000 61.95000  ? 454 HIS B CE1 1 
ATOM   4446 N NE2 . HIS B 1 336 ? 15.31897  16.82241  12.88738  1.000 60.99000  ? 454 HIS B NE2 1 
ATOM   4447 N N   . ARG B 1 337 ? 10.95242  16.18307  9.38337   1.000 52.00000  ? 455 ARG B N   1 
ATOM   4448 C CA  . ARG B 1 337 ? 9.69073   16.00721  10.09895  1.000 48.07000  ? 455 ARG B CA  1 
ATOM   4449 C C   . ARG B 1 337 ? 9.20766   14.56122  10.04035  1.000 52.40000  ? 455 ARG B C   1 
ATOM   4450 O O   . ARG B 1 337 ? 8.83809   13.98336  11.07059  1.000 51.15000  ? 455 ARG B O   1 
ATOM   4451 C CB  . ARG B 1 337 ? 8.61252   16.94017  9.55229   1.000 53.98000  ? 455 ARG B CB  1 
ATOM   4452 C CG  . ARG B 1 337 ? 7.25880   16.69430  10.22692  1.000 51.53000  ? 455 ARG B CG  1 
ATOM   4453 C CD  . ARG B 1 337 ? 6.19364   17.66827  9.79425   1.000 56.70000  ? 455 ARG B CD  1 
ATOM   4454 N NE  . ARG B 1 337 ? 6.16702   17.86508  8.34724   1.000 63.53000  ? 455 ARG B NE  1 
ATOM   4455 C CZ  . ARG B 1 337 ? 5.53662   17.05399  7.49462   1.000 62.17000  ? 455 ARG B CZ  1 
ATOM   4456 N NH1 . ARG B 1 337 ? 5.55006   17.30981  6.18958   1.000 62.12000  ? 455 ARG B NH1 1 
ATOM   4457 N NH2 . ARG B 1 337 ? 4.90578   15.97607  7.94304   1.000 57.58000  ? 455 ARG B NH2 1 
ATOM   4458 N N   . LEU B 1 338 ? 9.20612   13.95306  8.84943   1.000 51.40000  ? 456 LEU B N   1 
ATOM   4459 C CA  . LEU B 1 338 ? 8.72003   12.57506  8.73383   1.000 50.48000  ? 456 LEU B CA  1 
ATOM   4460 C C   . LEU B 1 338 ? 9.54737   11.60914  9.58360   1.000 49.55000  ? 456 LEU B C   1 
ATOM   4461 O O   . LEU B 1 338 ? 8.99962   10.69925  10.21596  1.000 53.34000  ? 456 LEU B O   1 
ATOM   4462 C CB  . LEU B 1 338 ? 8.72837   12.14286  7.27188   1.000 49.30000  ? 456 LEU B CB  1 
ATOM   4463 C CG  . LEU B 1 338 ? 7.95999   13.07076  6.32909   1.000 52.85000  ? 456 LEU B CG  1 
ATOM   4464 C CD1 . LEU B 1 338 ? 8.19334   12.68656  4.87304   1.000 39.02000  ? 456 LEU B CD1 1 
ATOM   4465 C CD2 . LEU B 1 338 ? 6.46314   13.09585  6.67274   1.000 47.85000  ? 456 LEU B CD2 1 
ATOM   4466 N N   . LEU B 1 339 ? 10.86439  11.80011  9.62800   1.000 47.34000  ? 457 LEU B N   1 
ATOM   4467 C CA  . LEU B 1 339 ? 11.71471  10.92519  10.42574  1.000 47.00000  ? 457 LEU B CA  1 
ATOM   4468 C C   . LEU B 1 339 ? 11.38337  11.02540  11.91487  1.000 47.94000  ? 457 LEU B C   1 
ATOM   4469 O O   . LEU B 1 339 ? 11.33665  10.01150  12.62403  1.000 47.47000  ? 457 LEU B O   1 
ATOM   4470 C CB  . LEU B 1 339 ? 13.17561  11.27111  10.15506  1.000 49.24000  ? 457 LEU B CB  1 
ATOM   4471 C CG  . LEU B 1 339 ? 13.61999  10.74591  8.78193   1.000 47.85000  ? 457 LEU B CG  1 
ATOM   4472 C CD1 . LEU B 1 339 ? 15.04486  11.14683  8.45126   1.000 47.18000  ? 457 LEU B CD1 1 
ATOM   4473 C CD2 . LEU B 1 339 ? 13.46892  9.23291   8.72320   1.000 42.86000  ? 457 LEU B CD2 1 
ATOM   4474 N N   . GLN B 1 340 ? 11.13962  12.24347  12.41182  1.000 57.22000  ? 458 GLN B N   1 
ATOM   4475 C CA  . GLN B 1 340 ? 10.73924  12.39567  13.80797  1.000 51.05000  ? 458 GLN B CA  1 
ATOM   4476 C C   . GLN B 1 340 ? 9.32334   11.92475  14.07965  1.000 48.85000  ? 458 GLN B C   1 
ATOM   4477 O O   . GLN B 1 340 ? 8.99983   11.61392  15.23183  1.000 50.14000  ? 458 GLN B O   1 
ATOM   4478 C CB  . GLN B 1 340 ? 10.87348  13.84073  14.25772  1.000 49.94000  ? 458 GLN B CB  1 
ATOM   4479 C CG  . GLN B 1 340 ? 12.24666  14.20774  14.66007  1.000 52.59000  ? 458 GLN B CG  1 
ATOM   4480 C CD  . GLN B 1 340 ? 12.41776  15.67875  14.78680  1.000 55.66000  ? 458 GLN B CD  1 
ATOM   4481 O OE1 . GLN B 1 340 ? 13.53880  16.17373  14.84124  1.000 67.62000  ? 458 GLN B OE1 1 
ATOM   4482 N NE2 . GLN B 1 340 ? 11.31178  16.40479  14.78219  1.000 64.11000  ? 458 GLN B NE2 1 
ATOM   4483 N N   . GLU B 1 341 ? 8.47489   11.86364  13.06003  1.000 49.88000  ? 459 GLU B N   1 
ATOM   4484 C CA  . GLU B 1 341 ? 7.11298   11.42971  13.29268  1.000 51.91000  ? 459 GLU B CA  1 
ATOM   4485 C C   . GLU B 1 341 ? 7.07506   9.93675   13.57890  1.000 59.52000  ? 459 GLU B C   1 
ATOM   4486 O O   . GLU B 1 341 ? 8.08200   9.21571   13.48456  1.000 62.73000  ? 459 GLU B O   1 
ATOM   4487 C CB  . GLU B 1 341 ? 6.22947   11.76858  12.10002  1.000 56.48000  ? 459 GLU B CB  1 
ATOM   4488 C CG  . GLU B 1 341 ? 5.50557   13.09062  12.24516  1.000 50.93000  ? 459 GLU B CG  1 
ATOM   4489 C CD  . GLU B 1 341 ? 5.12101   13.63146  10.91226  1.000 55.81000  ? 459 GLU B CD  1 
ATOM   4490 O OE1 . GLU B 1 341 ? 5.30357   12.86032  9.95328   1.000 55.67000  ? 459 GLU B OE1 1 
ATOM   4491 O OE2 . GLU B 1 341 ? 4.65300   14.79746  10.81831  1.000 60.41000  ? 459 GLU B OE2 1 
ATOM   4492 N N   . GLY B 1 342 ? 5.88321   9.47484   13.94748  1.000 60.32000  ? 460 GLY B N   1 
ATOM   4493 C CA  . GLY B 1 342 ? 5.68535   8.10890   14.36775  1.000 74.99000  ? 460 GLY B CA  1 
ATOM   4494 C C   . GLY B 1 342 ? 5.03285   7.26278   13.28415  1.000 89.94000  ? 460 GLY B C   1 
ATOM   4495 O O   . GLY B 1 342 ? 4.79137   7.70263   12.15619  1.000 79.72000  ? 460 GLY B O   1 
ATOM   4496 N N   . SER B 1 343 ? 4.73598   6.02184   13.66744  1.000 88.30000  ? 461 SER B N   1 
ATOM   4497 C CA  . SER B 1 343 ? 4.09056   5.06974   12.78185  1.000 79.51000  ? 461 SER B CA  1 
ATOM   4498 C C   . SER B 1 343 ? 2.86082   4.42986   13.41547  1.000 85.15000  ? 461 SER B C   1 
ATOM   4499 O O   . SER B 1 343 ? 1.75059   4.55082   12.88394  1.000 86.95000  ? 461 SER B O   1 
ATOM   4500 C CB  . SER B 1 343 ? 5.09835   4.01265   12.37555  1.000 70.42000  ? 461 SER B CB  1 
ATOM   4501 O OG  . SER B 1 343 ? 5.60484   3.38279   13.52942  1.000 87.37000  ? 461 SER B OG  1 
HETATM 4502 C C1  . SRL C 2 .   ? -29.83800 10.56300  -26.56900 1.000 54.66000  ? 501 SRL A C1  1 
HETATM 4503 C C2  . SRL C 2 .   ? -28.52500 10.94700  -26.89600 1.000 49.55000  ? 501 SRL A C2  1 
HETATM 4504 C C3  . SRL C 2 .   ? -27.98900 12.10100  -26.33800 1.000 49.35000  ? 501 SRL A C3  1 
HETATM 4505 C C4  . SRL C 2 .   ? -28.74700 12.88300  -25.45500 1.000 56.32000  ? 501 SRL A C4  1 
HETATM 4506 C C5  . SRL C 2 .   ? -30.04100 12.52400  -25.12200 1.000 52.17000  ? 501 SRL A C5  1 
HETATM 4507 C C6  . SRL C 2 .   ? -30.59000 11.36500  -25.68300 1.000 54.16000  ? 501 SRL A C6  1 
HETATM 4508 C C7  . SRL C 2 .   ? -30.77800 13.46500  -24.12100 1.000 55.62000  ? 501 SRL A C7  1 
HETATM 4509 C C8  . SRL C 2 .   ? -32.16800 13.08000  -23.50600 1.000 57.64000  ? 501 SRL A C8  1 
HETATM 4510 P P9  . SRL C 2 .   ? -32.96000 14.41400  -22.49400 1.000 51.04000  ? 501 SRL A P9  1 
HETATM 4511 P P10 . SRL C 2 .   ? -32.54500 11.38700  -22.86900 1.000 58.85000  ? 501 SRL A P10 1 
HETATM 4512 O O11 . SRL C 2 .   ? -27.73600 10.19000  -27.77800 1.000 56.56000  ? 501 SRL A O11 1 
HETATM 4513 C C12 . SRL C 2 .   ? -30.46500 9.27100   -27.15900 1.000 50.04000  ? 501 SRL A C12 1 
HETATM 4514 C C13 . SRL C 2 .   ? -26.55100 12.56700  -26.62600 1.000 49.73000  ? 501 SRL A C13 1 
HETATM 4515 C C14 . SRL C 2 .   ? -31.82700 8.92600   -26.54000 1.000 44.67000  ? 501 SRL A C14 1 
HETATM 4516 C C15 . SRL C 2 .   ? -29.56700 8.08100   -26.79500 1.000 47.52000  ? 501 SRL A C15 1 
HETATM 4517 C C16 . SRL C 2 .   ? -30.58200 9.42100   -28.67900 1.000 45.00000  ? 501 SRL A C16 1 
HETATM 4518 C C17 . SRL C 2 .   ? -25.60800 11.43100  -26.22800 1.000 51.17000  ? 501 SRL A C17 1 
HETATM 4519 C C18 . SRL C 2 .   ? -26.33900 12.99500  -28.07400 1.000 47.29000  ? 501 SRL A C18 1 
HETATM 4520 C C19 . SRL C 2 .   ? -26.24000 13.76800  -25.73300 1.000 50.77000  ? 501 SRL A C19 1 
HETATM 4521 O O20 . SRL C 2 .   ? -33.18400 15.51400  -23.42300 1.000 54.68000  ? 501 SRL A O20 1 
HETATM 4522 O O21 . SRL C 2 .   ? -34.39300 13.92600  -21.83300 1.000 65.69000  ? 501 SRL A O21 1 
HETATM 4523 C C22 . SRL C 2 .   ? -35.54900 13.74100  -22.60200 1.000 52.99000  ? 501 SRL A C22 1 
HETATM 4524 C C23 . SRL C 2 .   ? -36.60800 14.70200  -22.07800 1.000 53.68000  ? 501 SRL A C23 1 
HETATM 4525 O O24 . SRL C 2 .   ? -31.93800 14.88500  -21.27200 1.000 60.41000  ? 501 SRL A O24 1 
HETATM 4526 C C25 . SRL C 2 .   ? -31.62200 14.03600  -20.21400 1.000 54.14000  ? 501 SRL A C25 1 
HETATM 4527 C C26 . SRL C 2 .   ? -30.41100 14.62700  -19.49200 1.000 53.33000  ? 501 SRL A C26 1 
HETATM 4528 O O27 . SRL C 2 .   ? -33.67600 10.92400  -23.67200 1.000 61.52000  ? 501 SRL A O27 1 
HETATM 4529 O O28 . SRL C 2 .   ? -31.32200 10.31000  -23.07200 1.000 55.13000  ? 501 SRL A O28 1 
HETATM 4530 C C29 . SRL C 2 .   ? -30.32200 10.17700  -22.11300 1.000 57.05000  ? 501 SRL A C29 1 
HETATM 4531 C C30 . SRL C 2 .   ? -29.18400 9.63100   -22.96400 1.000 66.46000  ? 501 SRL A C30 1 
HETATM 4532 O O31 . SRL C 2 .   ? -32.99300 11.47700  -21.27000 1.000 58.99000  ? 501 SRL A O31 1 
HETATM 4533 C C32 . SRL C 2 .   ? -34.24700 11.00000  -20.86700 1.000 53.70000  ? 501 SRL A C32 1 
HETATM 4534 C C33 . SRL C 2 .   ? -34.07300 10.19900  -19.57400 1.000 54.75000  ? 501 SRL A C33 1 
HETATM 4535 C C1  . SRL D 2 .   ? 6.51800   5.52600   -13.47900 1.000 49.08000  ? 501 SRL B C1  1 
HETATM 4536 C C2  . SRL D 2 .   ? 7.35200   4.86200   -14.37400 1.000 49.20000  ? 501 SRL B C2  1 
HETATM 4537 C C3  . SRL D 2 .   ? 8.70100   5.23400   -14.50100 1.000 57.76000  ? 501 SRL B C3  1 
HETATM 4538 C C4  . SRL D 2 .   ? 9.21900   6.27800   -13.70700 1.000 49.86000  ? 501 SRL B C4  1 
HETATM 4539 C C5  . SRL D 2 .   ? 8.36900   6.92500   -12.82500 1.000 52.07000  ? 501 SRL B C5  1 
HETATM 4540 C C6  . SRL D 2 .   ? 7.03800   6.55500   -12.71500 1.000 47.44000  ? 501 SRL B C6  1 
HETATM 4541 C C7  . SRL D 2 .   ? 8.78900   8.09500   -11.90100 1.000 57.60000  ? 501 SRL B C7  1 
HETATM 4542 C C8  . SRL D 2 .   ? 10.15100  8.80100   -12.12700 1.000 54.89000  ? 501 SRL B C8  1 
HETATM 4543 P P9  . SRL D 2 .   ? 10.43300  10.04700  -10.80100 1.000 58.15000  ? 501 SRL B P9  1 
HETATM 4544 P P10 . SRL D 2 .   ? 10.66200  9.33600   -13.83100 1.000 60.18000  ? 501 SRL B P10 1 
HETATM 4545 O O11 . SRL D 2 .   ? 6.81700   3.83000   -15.15700 1.000 48.83000  ? 501 SRL B O11 1 
HETATM 4546 C C12 . SRL D 2 .   ? 5.02100   5.19900   -13.28100 1.000 53.36000  ? 501 SRL B C12 1 
HETATM 4547 C C13 . SRL D 2 .   ? 9.63400   4.50500   -15.51300 1.000 58.91000  ? 501 SRL B C13 1 
HETATM 4548 C C14 . SRL D 2 .   ? 4.47200   6.28100   -12.35800 1.000 45.82000  ? 501 SRL B C14 1 
HETATM 4549 C C15 . SRL D 2 .   ? 4.81200   3.82400   -12.61800 1.000 37.97000  ? 501 SRL B C15 1 
HETATM 4550 C C16 . SRL D 2 .   ? 4.24500   5.30400   -14.60600 1.000 49.85000  ? 501 SRL B C16 1 
HETATM 4551 C C17 . SRL D 2 .   ? 9.07700   4.64100   -16.94400 1.000 48.21000  ? 501 SRL B C17 1 
HETATM 4552 C C18 . SRL D 2 .   ? 11.03600  5.12400   -15.48500 1.000 57.24000  ? 501 SRL B C18 1 
HETATM 4553 C C19 . SRL D 2 .   ? 9.77000   3.03800   -15.12300 1.000 46.93000  ? 501 SRL B C19 1 
HETATM 4554 O O20 . SRL D 2 .   ? 10.18500  9.37800   -9.53600  1.000 56.55000  ? 501 SRL B O20 1 
HETATM 4555 O O21 . SRL D 2 .   ? 9.44700   11.39100  -10.92200 1.000 66.87000  ? 501 SRL B O21 1 
HETATM 4556 C C22 . SRL D 2 .   ? 8.54500   11.55200  -11.99000 1.000 56.39000  ? 501 SRL B C22 1 
HETATM 4557 C C23 . SRL D 2 .   ? 7.76200   12.82900  -11.74800 1.000 55.26000  ? 501 SRL B C23 1 
HETATM 4558 O O24 . SRL D 2 .   ? 12.01700  10.49500  -10.98900 1.000 70.26000  ? 501 SRL B O24 1 
HETATM 4559 C C25 . SRL D 2 .   ? 12.82800  10.84700  -9.90700  1.000 61.14000  ? 501 SRL B C25 1 
HETATM 4560 C C26 . SRL D 2 .   ? 14.28000  10.74700  -10.40100 1.000 53.84000  ? 501 SRL B C26 1 
HETATM 4561 O O27 . SRL D 2 .   ? 11.86300  8.56200   -14.14900 1.000 57.39000  ? 501 SRL B O27 1 
HETATM 4562 O O28 . SRL D 2 .   ? 10.96700  10.96600  -13.88100 1.000 59.70000  ? 501 SRL B O28 1 
HETATM 4563 C C29 . SRL D 2 .   ? 12.28400  11.45400  -13.93400 1.000 59.31000  ? 501 SRL B C29 1 
HETATM 4564 C C30 . SRL D 2 .   ? 12.50900  12.16400  -15.26900 1.000 59.23000  ? 501 SRL B C30 1 
HETATM 4565 O O31 . SRL D 2 .   ? 9.47200   9.04700   -14.94700 1.000 65.16000  ? 501 SRL B O31 1 
HETATM 4566 C C32 . SRL D 2 .   ? 9.06700   10.12400  -15.75500 1.000 66.66000  ? 501 SRL B C32 1 
HETATM 4567 C C33 . SRL D 2 .   ? 8.51700   9.57500   -17.08200 1.000 69.01000  ? 501 SRL B C33 1 
HETATM 4568 O O   . HOH E 3 .   ? -27.44100 14.47600  -41.06700 1.000 30.47000  ? 601 HOH A O   1 
HETATM 4569 O O   . HOH E 3 .   ? -44.46300 22.07700  -30.66800 1.000 41.13000  ? 602 HOH A O   1 
HETATM 4570 O O   . HOH E 3 .   ? -30.34200 22.15500  -41.36800 1.000 36.76000  ? 603 HOH A O   1 
HETATM 4571 O O   . HOH E 3 .   ? -46.53600 21.77400  -24.58000 1.000 44.99000  ? 604 HOH A O   1 
HETATM 4572 O O   . HOH E 3 .   ? -29.44200 23.45400  -30.27600 1.000 37.33000  ? 605 HOH A O   1 
HETATM 4573 O O   . HOH E 3 .   ? -30.94300 12.42800  -43.26200 1.000 33.47000  ? 606 HOH A O   1 
HETATM 4574 O O   . HOH E 3 .   ? -31.25700 25.74400  -16.38200 1.000 40.41000  ? 607 HOH A O   1 
HETATM 4575 O O   . HOH E 3 .   ? -38.46700 4.50000   -34.24600 1.000 49.62000  ? 608 HOH A O   1 
HETATM 4576 O O   . HOH E 3 .   ? -31.93700 31.02200  -25.27400 1.000 40.52000  ? 609 HOH A O   1 
HETATM 4577 O O   . HOH E 3 .   ? -26.74800 23.26800  -17.54700 1.000 40.73000  ? 610 HOH A O   1 
HETATM 4578 O O   . HOH E 3 .   ? -21.24600 12.92500  -38.27100 1.000 45.61000  ? 611 HOH A O   1 
HETATM 4579 O O   . HOH E 3 .   ? -32.60000 34.58700  -30.53800 1.000 50.43000  ? 612 HOH A O   1 
HETATM 4580 O O   . HOH E 3 .   ? -28.06100 30.23400  -29.35400 1.000 46.43000  ? 613 HOH A O   1 
HETATM 4581 O O   . HOH E 3 .   ? -32.37400 22.87500  -10.18800 1.000 53.10000  ? 614 HOH A O   1 
HETATM 4582 O O   . HOH E 3 .   ? -32.06800 28.48800  -48.69700 1.000 53.82000  ? 615 HOH A O   1 
HETATM 4583 O O   . HOH E 3 .   ? -15.60800 22.06900  -26.23800 1.000 58.38000  ? 616 HOH A O   1 
HETATM 4584 O O   . HOH E 3 .   ? -23.54700 30.05600  -32.91800 1.000 42.25000  ? 617 HOH A O   1 
HETATM 4585 O O   . HOH E 3 .   ? -47.00700 15.80900  -37.53200 1.000 50.69000  ? 618 HOH A O   1 
HETATM 4586 O O   . HOH E 3 .   ? -50.80700 17.86300  -46.19000 1.000 51.55000  ? 619 HOH A O   1 
HETATM 4587 O O   . HOH F 3 .   ? 20.94700  4.62100   0.57600   1.000 41.77000  ? 601 HOH B O   1 
HETATM 4588 O O   . HOH F 3 .   ? -0.58700  15.79000  -14.77900 1.000 50.80000  ? 602 HOH B O   1 
HETATM 4589 O O   . HOH F 3 .   ? 24.09400  -20.56100 -8.57000  1.000 51.53000  ? 603 HOH B O   1 
HETATM 4590 O O   . HOH F 3 .   ? 7.18900   -9.01900  -9.37700  1.000 34.86000  ? 604 HOH B O   1 
HETATM 4591 O O   . HOH F 3 .   ? 6.25300   2.95700   -1.70600  1.000 46.36000  ? 605 HOH B O   1 
HETATM 4592 O O   . HOH F 3 .   ? 16.22500  -17.08400 -11.60400 1.000 64.79000  ? 606 HOH B O   1 
HETATM 4593 O O   . HOH F 3 .   ? -6.92500  5.88000   -5.63300  1.000 52.49000  ? 607 HOH B O   1 
HETATM 4594 O O   . HOH F 3 .   ? 19.01700  -1.70100  -17.98500 1.000 49.12000  ? 608 HOH B O   1 
HETATM 4595 O O   . HOH F 3 .   ? 4.02400   14.09100  -19.27500 1.000 54.47000  ? 609 HOH B O   1 
HETATM 4596 O O   . HOH F 3 .   ? 22.59700  -17.45200 -5.99700  1.000 39.39000  ? 610 HOH B O   1 
HETATM 4597 O O   . HOH F 3 .   ? 6.45100   8.94500   6.30500   1.000 42.90000  ? 611 HOH B O   1 
HETATM 4598 O O   . HOH F 3 .   ? 21.67300  -20.18500 -6.79500  1.000 48.81000  ? 612 HOH B O   1 
HETATM 4599 O O   . HOH F 3 .   ? 7.43700   -11.87600 -8.83100  1.000 30.00000  ? 613 HOH B O   1 
HETATM 4600 O O   . HOH F 3 .   ? 25.07400  -16.40600 -7.20100  1.000 33.70000  ? 614 HOH B O   1 
HETATM 4601 O O   . HOH F 3 .   ? 27.589    -9.191    -8.688    1.000 49.00000  ? 615 HOH B O   1 
HETATM 4602 O O   . HOH F 3 .   ? 21.20700  9.04200   -5.87400  1.000 51.67000  ? 616 HOH B O   1 
HETATM 4603 O O   . HOH F 3 .   ? 5.41000   17.15000  -1.01800  1.000 44.45000  ? 617 HOH B O   1 
HETATM 4604 O O   . HOH F 3 .   ? 14.604    19.170    16.162    1.000 42.41000  ? 618 HOH B O   1 
HETATM 4605 O O   . HOH F 3 .   ? 3.96400   10.68300  -26.77300 1.000 52.43000  ? 619 HOH B O   1 
HETATM 4606 O O   . HOH F 3 .   ? -0.54200  1.73600   4.37900   1.000 62.56000  ? 620 HOH B O   1 
HETATM 4607 O O   . HOH F 3 .   ? 23.043    -9.096    -14.859   1.000 48.53000  ? 621 HOH B O   1 
HETATM 4608 O O   . HOH F 3 .   ? 14.782    17.007    18.959    1.000 54.07000  ? 622 HOH B O   1 
HETATM 4609 O O   . HOH F 3 .   ? 2.92600   16.66800  -2.12200  1.000 55.06000  ? 623 HOH B O   1 
HETATM 4610 O O   . HOH F 3 .   ? 29.55800  -11.34500 0.83800   1.000 60.66000  ? 624 HOH B O   1 
# 
