data_9FZG
# 
_entry.id   9FZG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FZG         pdb_00009fzg 10.2210/pdb9fzg/pdb 
WWPDB D_1292139842 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-19 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FZG 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              bourguet@cbs.cnrs.fr 
_pdbx_contact_author.name_first         William 
_pdbx_contact_author.name_last          Bourguet 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0643-7719 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Delfosse, V.' 1 0000-0002-7436-7935 
'Bourguet, W.' 2 0000-0002-0643-7719 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acta Crystallogr.,Sect.F' 
_citation.journal_id_ASTM           ACSFEN 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2053-230X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            81 
_citation.language                  ? 
_citation.page_first                85 
_citation.page_last                 94 
_citation.title                     
;A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1107/S2053230X2500069X 
_citation.pdbx_database_id_PubMed   39923198 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Carivenc, C.' 1 ? 
primary 'Laconde, G.'  2 ? 
primary 'Blanc, P.'    3 ? 
primary 'Amblard, M.'  4 ? 
primary 'Bourguet, W.' 5 ? 
primary 'Delfosse, V.' 6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Nuclear receptor subfamily 1 group I member 2' 36747.465 1   ? ? ? ? 
2 non-polymer syn 
;2-(1-adamantyl)-~{N}-[2-[2-[2-oxidanylidene-2-[7-[1-(phenylmethyl)-5-[(2,4,6-trimethylphenyl)sulfonylamino]benzimidazol-2-yl]heptylamino]ethoxy]ethoxy]ethyl]ethanamide
;
840.125   1   ? ? ? ? 
3 non-polymer syn GLYCEROL 92.094    2   ? ? ? ? 
4 non-polymer syn 'ISOPROPYL ALCOHOL' 60.095    2   ? ? ? ? 
5 water       nat water 18.015    199 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKKGHHHHHHGSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAK
WSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKG
AAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQ
HRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGSLVPR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKKGHHHHHHGSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAK
WSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKG
AAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQ
HRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGSLVPR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;2-(1-adamantyl)-~{N}-[2-[2-[2-oxidanylidene-2-[7-[1-(phenylmethyl)-5-[(2,4,6-trimethylphenyl)sulfonylamino]benzimidazol-2-yl]heptylamino]ethoxy]ethoxy]ethyl]ethanamide
;
A1IHA 
3 GLYCEROL GOL   
4 'ISOPROPYL ALCOHOL' IPA   
5 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   LYS n 
1 4   GLY n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  GLY n 
1 12  SER n 
1 13  GLU n 
1 14  ARG n 
1 15  THR n 
1 16  GLY n 
1 17  THR n 
1 18  GLN n 
1 19  PRO n 
1 20  LEU n 
1 21  GLY n 
1 22  VAL n 
1 23  GLN n 
1 24  GLY n 
1 25  LEU n 
1 26  THR n 
1 27  GLU n 
1 28  GLU n 
1 29  GLN n 
1 30  ARG n 
1 31  MET n 
1 32  MET n 
1 33  ILE n 
1 34  ARG n 
1 35  GLU n 
1 36  LEU n 
1 37  MET n 
1 38  ASP n 
1 39  ALA n 
1 40  GLN n 
1 41  MET n 
1 42  LYS n 
1 43  THR n 
1 44  PHE n 
1 45  ASP n 
1 46  THR n 
1 47  THR n 
1 48  PHE n 
1 49  SER n 
1 50  HIS n 
1 51  PHE n 
1 52  LYS n 
1 53  ASN n 
1 54  PHE n 
1 55  ARG n 
1 56  LEU n 
1 57  PRO n 
1 58  GLY n 
1 59  VAL n 
1 60  LEU n 
1 61  SER n 
1 62  SER n 
1 63  GLY n 
1 64  CYS n 
1 65  GLU n 
1 66  LEU n 
1 67  PRO n 
1 68  GLU n 
1 69  SER n 
1 70  LEU n 
1 71  GLN n 
1 72  ALA n 
1 73  PRO n 
1 74  SER n 
1 75  ARG n 
1 76  GLU n 
1 77  GLU n 
1 78  ALA n 
1 79  ALA n 
1 80  LYS n 
1 81  TRP n 
1 82  SER n 
1 83  GLN n 
1 84  VAL n 
1 85  ARG n 
1 86  LYS n 
1 87  ASP n 
1 88  LEU n 
1 89  CYS n 
1 90  SER n 
1 91  LEU n 
1 92  LYS n 
1 93  VAL n 
1 94  SER n 
1 95  LEU n 
1 96  GLN n 
1 97  LEU n 
1 98  ARG n 
1 99  GLY n 
1 100 GLU n 
1 101 ASP n 
1 102 GLY n 
1 103 SER n 
1 104 VAL n 
1 105 TRP n 
1 106 ASN n 
1 107 TYR n 
1 108 LYS n 
1 109 PRO n 
1 110 PRO n 
1 111 ALA n 
1 112 ASP n 
1 113 SER n 
1 114 GLY n 
1 115 GLY n 
1 116 LYS n 
1 117 GLU n 
1 118 ILE n 
1 119 PHE n 
1 120 SER n 
1 121 LEU n 
1 122 LEU n 
1 123 PRO n 
1 124 HIS n 
1 125 MET n 
1 126 ALA n 
1 127 ASP n 
1 128 MET n 
1 129 SER n 
1 130 THR n 
1 131 TYR n 
1 132 MET n 
1 133 PHE n 
1 134 LYS n 
1 135 GLY n 
1 136 ILE n 
1 137 ILE n 
1 138 SER n 
1 139 PHE n 
1 140 ALA n 
1 141 LYS n 
1 142 VAL n 
1 143 ILE n 
1 144 SER n 
1 145 TYR n 
1 146 PHE n 
1 147 ARG n 
1 148 ASP n 
1 149 LEU n 
1 150 PRO n 
1 151 ILE n 
1 152 GLU n 
1 153 ASP n 
1 154 GLN n 
1 155 ILE n 
1 156 SER n 
1 157 LEU n 
1 158 LEU n 
1 159 LYS n 
1 160 GLY n 
1 161 ALA n 
1 162 ALA n 
1 163 PHE n 
1 164 GLU n 
1 165 LEU n 
1 166 CYS n 
1 167 GLN n 
1 168 LEU n 
1 169 ARG n 
1 170 PHE n 
1 171 ASN n 
1 172 THR n 
1 173 VAL n 
1 174 PHE n 
1 175 ASN n 
1 176 ALA n 
1 177 GLU n 
1 178 THR n 
1 179 GLY n 
1 180 THR n 
1 181 TRP n 
1 182 GLU n 
1 183 CYS n 
1 184 GLY n 
1 185 ARG n 
1 186 LEU n 
1 187 SER n 
1 188 TYR n 
1 189 CYS n 
1 190 LEU n 
1 191 GLU n 
1 192 ASP n 
1 193 THR n 
1 194 ALA n 
1 195 GLY n 
1 196 GLY n 
1 197 PHE n 
1 198 GLN n 
1 199 GLN n 
1 200 LEU n 
1 201 LEU n 
1 202 LEU n 
1 203 GLU n 
1 204 PRO n 
1 205 MET n 
1 206 LEU n 
1 207 LYS n 
1 208 PHE n 
1 209 HIS n 
1 210 TYR n 
1 211 MET n 
1 212 LEU n 
1 213 LYS n 
1 214 LYS n 
1 215 LEU n 
1 216 GLN n 
1 217 LEU n 
1 218 HIS n 
1 219 GLU n 
1 220 GLU n 
1 221 GLU n 
1 222 TYR n 
1 223 VAL n 
1 224 LEU n 
1 225 MET n 
1 226 GLN n 
1 227 ALA n 
1 228 ILE n 
1 229 SER n 
1 230 LEU n 
1 231 PHE n 
1 232 SER n 
1 233 PRO n 
1 234 ASP n 
1 235 ARG n 
1 236 PRO n 
1 237 GLY n 
1 238 VAL n 
1 239 LEU n 
1 240 GLN n 
1 241 HIS n 
1 242 ARG n 
1 243 VAL n 
1 244 VAL n 
1 245 ASP n 
1 246 GLN n 
1 247 LEU n 
1 248 GLN n 
1 249 GLU n 
1 250 GLN n 
1 251 PHE n 
1 252 ALA n 
1 253 ILE n 
1 254 THR n 
1 255 LEU n 
1 256 LYS n 
1 257 SER n 
1 258 TYR n 
1 259 ILE n 
1 260 GLU n 
1 261 CYS n 
1 262 ASN n 
1 263 ARG n 
1 264 PRO n 
1 265 GLN n 
1 266 PRO n 
1 267 ALA n 
1 268 HIS n 
1 269 ARG n 
1 270 PHE n 
1 271 LEU n 
1 272 PHE n 
1 273 LEU n 
1 274 LYS n 
1 275 ILE n 
1 276 MET n 
1 277 ALA n 
1 278 MET n 
1 279 LEU n 
1 280 THR n 
1 281 GLU n 
1 282 LEU n 
1 283 ARG n 
1 284 SER n 
1 285 ILE n 
1 286 ASN n 
1 287 ALA n 
1 288 GLN n 
1 289 HIS n 
1 290 THR n 
1 291 GLN n 
1 292 ARG n 
1 293 LEU n 
1 294 LEU n 
1 295 ARG n 
1 296 ILE n 
1 297 GLN n 
1 298 ASP n 
1 299 ILE n 
1 300 HIS n 
1 301 PRO n 
1 302 PHE n 
1 303 ALA n 
1 304 THR n 
1 305 PRO n 
1 306 LEU n 
1 307 MET n 
1 308 GLN n 
1 309 GLU n 
1 310 LEU n 
1 311 PHE n 
1 312 GLY n 
1 313 ILE n 
1 314 THR n 
1 315 GLY n 
1 316 SER n 
1 317 LEU n 
1 318 VAL n 
1 319 PRO n 
1 320 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   320 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'NR1I2, PXR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1IHA non-polymer         . 
;2-(1-adamantyl)-~{N}-[2-[2-[2-oxidanylidene-2-[7-[1-(phenylmethyl)-5-[(2,4,6-trimethylphenyl)sulfonylamino]benzimidazol-2-yl]heptylamino]ethoxy]ethoxy]ethyl]ethanamide
;
?                               'C48 H65 N5 O6 S' 840.125 
ALA   'L-peptide linking' y ALANINE ?                               'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ?                               'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ?                               'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ?                               'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ?                               'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ?                               'C2 H5 N O2'      75.067  
GOL   non-polymer         . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'        92.094  
HIS   'L-peptide linking' y HISTIDINE ?                               'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ?                               'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ?                               'C6 H13 N O2'     131.173 
IPA   non-polymer         . 'ISOPROPYL ALCOHOL' 2-PROPANOL                      'C3 H8 O'         60.095  
LEU   'L-peptide linking' y LEUCINE ?                               'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ?                               'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ?                               'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?                               'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ?                               'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ?                               'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ?                               'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?                               'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ?                               'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ?                               'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   119 ?   ?   ?   A . n 
A 1 2   LYS 2   120 ?   ?   ?   A . n 
A 1 3   LYS 3   121 ?   ?   ?   A . n 
A 1 4   GLY 4   122 ?   ?   ?   A . n 
A 1 5   HIS 5   123 ?   ?   ?   A . n 
A 1 6   HIS 6   124 ?   ?   ?   A . n 
A 1 7   HIS 7   125 ?   ?   ?   A . n 
A 1 8   HIS 8   126 ?   ?   ?   A . n 
A 1 9   HIS 9   127 ?   ?   ?   A . n 
A 1 10  HIS 10  128 ?   ?   ?   A . n 
A 1 11  GLY 11  129 ?   ?   ?   A . n 
A 1 12  SER 12  130 ?   ?   ?   A . n 
A 1 13  GLU 13  131 ?   ?   ?   A . n 
A 1 14  ARG 14  132 ?   ?   ?   A . n 
A 1 15  THR 15  133 ?   ?   ?   A . n 
A 1 16  GLY 16  134 ?   ?   ?   A . n 
A 1 17  THR 17  135 ?   ?   ?   A . n 
A 1 18  GLN 18  136 ?   ?   ?   A . n 
A 1 19  PRO 19  137 ?   ?   ?   A . n 
A 1 20  LEU 20  138 ?   ?   ?   A . n 
A 1 21  GLY 21  139 ?   ?   ?   A . n 
A 1 22  VAL 22  140 ?   ?   ?   A . n 
A 1 23  GLN 23  141 ?   ?   ?   A . n 
A 1 24  GLY 24  142 142 GLY GLY A . n 
A 1 25  LEU 25  143 143 LEU LEU A . n 
A 1 26  THR 26  144 144 THR THR A . n 
A 1 27  GLU 27  145 145 GLU GLU A . n 
A 1 28  GLU 28  146 146 GLU GLU A . n 
A 1 29  GLN 29  147 147 GLN GLN A . n 
A 1 30  ARG 30  148 148 ARG ARG A . n 
A 1 31  MET 31  149 149 MET MET A . n 
A 1 32  MET 32  150 150 MET MET A . n 
A 1 33  ILE 33  151 151 ILE ILE A . n 
A 1 34  ARG 34  152 152 ARG ARG A . n 
A 1 35  GLU 35  153 153 GLU GLU A . n 
A 1 36  LEU 36  154 154 LEU LEU A . n 
A 1 37  MET 37  155 155 MET MET A . n 
A 1 38  ASP 38  156 156 ASP ASP A . n 
A 1 39  ALA 39  157 157 ALA ALA A . n 
A 1 40  GLN 40  158 158 GLN GLN A . n 
A 1 41  MET 41  159 159 MET MET A . n 
A 1 42  LYS 42  160 160 LYS LYS A . n 
A 1 43  THR 43  161 161 THR THR A . n 
A 1 44  PHE 44  162 162 PHE PHE A . n 
A 1 45  ASP 45  163 163 ASP ASP A . n 
A 1 46  THR 46  164 164 THR THR A . n 
A 1 47  THR 47  165 165 THR THR A . n 
A 1 48  PHE 48  166 166 PHE PHE A . n 
A 1 49  SER 49  167 167 SER SER A . n 
A 1 50  HIS 50  168 168 HIS HIS A . n 
A 1 51  PHE 51  169 169 PHE PHE A . n 
A 1 52  LYS 52  170 170 LYS LYS A . n 
A 1 53  ASN 53  171 171 ASN ASN A . n 
A 1 54  PHE 54  172 172 PHE PHE A . n 
A 1 55  ARG 55  173 173 ARG ARG A . n 
A 1 56  LEU 56  174 174 LEU LEU A . n 
A 1 57  PRO 57  175 175 PRO PRO A . n 
A 1 58  GLY 58  176 176 GLY GLY A . n 
A 1 59  VAL 59  177 177 VAL VAL A . n 
A 1 60  LEU 60  178 ?   ?   ?   A . n 
A 1 61  SER 61  179 ?   ?   ?   A . n 
A 1 62  SER 62  180 ?   ?   ?   A . n 
A 1 63  GLY 63  181 ?   ?   ?   A . n 
A 1 64  CYS 64  182 ?   ?   ?   A . n 
A 1 65  GLU 65  183 ?   ?   ?   A . n 
A 1 66  LEU 66  184 ?   ?   ?   A . n 
A 1 67  PRO 67  185 ?   ?   ?   A . n 
A 1 68  GLU 68  186 ?   ?   ?   A . n 
A 1 69  SER 69  187 ?   ?   ?   A . n 
A 1 70  LEU 70  188 ?   ?   ?   A . n 
A 1 71  GLN 71  189 ?   ?   ?   A . n 
A 1 72  ALA 72  190 ?   ?   ?   A . n 
A 1 73  PRO 73  191 ?   ?   ?   A . n 
A 1 74  SER 74  192 ?   ?   ?   A . n 
A 1 75  ARG 75  193 ?   ?   ?   A . n 
A 1 76  GLU 76  194 ?   ?   ?   A . n 
A 1 77  GLU 77  195 ?   ?   ?   A . n 
A 1 78  ALA 78  196 ?   ?   ?   A . n 
A 1 79  ALA 79  197 ?   ?   ?   A . n 
A 1 80  LYS 80  198 ?   ?   ?   A . n 
A 1 81  TRP 81  199 ?   ?   ?   A . n 
A 1 82  SER 82  200 ?   ?   ?   A . n 
A 1 83  GLN 83  201 ?   ?   ?   A . n 
A 1 84  VAL 84  202 ?   ?   ?   A . n 
A 1 85  ARG 85  203 ?   ?   ?   A . n 
A 1 86  LYS 86  204 ?   ?   ?   A . n 
A 1 87  ASP 87  205 ?   ?   ?   A . n 
A 1 88  LEU 88  206 ?   ?   ?   A . n 
A 1 89  CYS 89  207 ?   ?   ?   A . n 
A 1 90  SER 90  208 208 SER SER A . n 
A 1 91  LEU 91  209 209 LEU LEU A . n 
A 1 92  LYS 92  210 210 LYS LYS A . n 
A 1 93  VAL 93  211 211 VAL VAL A . n 
A 1 94  SER 94  212 212 SER SER A . n 
A 1 95  LEU 95  213 213 LEU LEU A . n 
A 1 96  GLN 96  214 214 GLN GLN A . n 
A 1 97  LEU 97  215 215 LEU LEU A . n 
A 1 98  ARG 98  216 216 ARG ARG A . n 
A 1 99  GLY 99  217 217 GLY GLY A . n 
A 1 100 GLU 100 218 218 GLU GLU A . n 
A 1 101 ASP 101 219 219 ASP ASP A . n 
A 1 102 GLY 102 220 220 GLY GLY A . n 
A 1 103 SER 103 221 221 SER SER A . n 
A 1 104 VAL 104 222 222 VAL VAL A . n 
A 1 105 TRP 105 223 223 TRP TRP A . n 
A 1 106 ASN 106 224 224 ASN ASN A . n 
A 1 107 TYR 107 225 225 TYR TYR A . n 
A 1 108 LYS 108 226 226 LYS LYS A . n 
A 1 109 PRO 109 227 227 PRO PRO A . n 
A 1 110 PRO 110 228 228 PRO PRO A . n 
A 1 111 ALA 111 229 229 ALA ALA A . n 
A 1 112 ASP 112 230 230 ASP ASP A . n 
A 1 113 SER 113 231 231 SER SER A . n 
A 1 114 GLY 114 232 232 GLY GLY A . n 
A 1 115 GLY 115 233 233 GLY GLY A . n 
A 1 116 LYS 116 234 234 LYS LYS A . n 
A 1 117 GLU 117 235 235 GLU GLU A . n 
A 1 118 ILE 118 236 236 ILE ILE A . n 
A 1 119 PHE 119 237 237 PHE PHE A . n 
A 1 120 SER 120 238 238 SER SER A . n 
A 1 121 LEU 121 239 239 LEU LEU A . n 
A 1 122 LEU 122 240 240 LEU LEU A . n 
A 1 123 PRO 123 241 241 PRO PRO A . n 
A 1 124 HIS 124 242 242 HIS HIS A . n 
A 1 125 MET 125 243 243 MET MET A . n 
A 1 126 ALA 126 244 244 ALA ALA A . n 
A 1 127 ASP 127 245 245 ASP ASP A . n 
A 1 128 MET 128 246 246 MET MET A . n 
A 1 129 SER 129 247 247 SER SER A . n 
A 1 130 THR 130 248 248 THR THR A . n 
A 1 131 TYR 131 249 249 TYR TYR A . n 
A 1 132 MET 132 250 250 MET MET A . n 
A 1 133 PHE 133 251 251 PHE PHE A . n 
A 1 134 LYS 134 252 252 LYS LYS A . n 
A 1 135 GLY 135 253 253 GLY GLY A . n 
A 1 136 ILE 136 254 254 ILE ILE A . n 
A 1 137 ILE 137 255 255 ILE ILE A . n 
A 1 138 SER 138 256 256 SER SER A . n 
A 1 139 PHE 139 257 257 PHE PHE A . n 
A 1 140 ALA 140 258 258 ALA ALA A . n 
A 1 141 LYS 141 259 259 LYS LYS A . n 
A 1 142 VAL 142 260 260 VAL VAL A . n 
A 1 143 ILE 143 261 261 ILE ILE A . n 
A 1 144 SER 144 262 262 SER SER A . n 
A 1 145 TYR 145 263 263 TYR TYR A . n 
A 1 146 PHE 146 264 264 PHE PHE A . n 
A 1 147 ARG 147 265 265 ARG ARG A . n 
A 1 148 ASP 148 266 266 ASP ASP A . n 
A 1 149 LEU 149 267 267 LEU LEU A . n 
A 1 150 PRO 150 268 268 PRO PRO A . n 
A 1 151 ILE 151 269 269 ILE ILE A . n 
A 1 152 GLU 152 270 270 GLU GLU A . n 
A 1 153 ASP 153 271 271 ASP ASP A . n 
A 1 154 GLN 154 272 272 GLN GLN A . n 
A 1 155 ILE 155 273 273 ILE ILE A . n 
A 1 156 SER 156 274 274 SER SER A . n 
A 1 157 LEU 157 275 275 LEU LEU A . n 
A 1 158 LEU 158 276 276 LEU LEU A . n 
A 1 159 LYS 159 277 277 LYS LYS A . n 
A 1 160 GLY 160 278 278 GLY GLY A . n 
A 1 161 ALA 161 279 279 ALA ALA A . n 
A 1 162 ALA 162 280 280 ALA ALA A . n 
A 1 163 PHE 163 281 281 PHE PHE A . n 
A 1 164 GLU 164 282 282 GLU GLU A . n 
A 1 165 LEU 165 283 283 LEU LEU A . n 
A 1 166 CYS 166 284 284 CYS CYS A . n 
A 1 167 GLN 167 285 285 GLN GLN A . n 
A 1 168 LEU 168 286 286 LEU LEU A . n 
A 1 169 ARG 169 287 287 ARG ARG A . n 
A 1 170 PHE 170 288 288 PHE PHE A . n 
A 1 171 ASN 171 289 289 ASN ASN A . n 
A 1 172 THR 172 290 290 THR THR A . n 
A 1 173 VAL 173 291 291 VAL VAL A . n 
A 1 174 PHE 174 292 292 PHE PHE A . n 
A 1 175 ASN 175 293 293 ASN ASN A . n 
A 1 176 ALA 176 294 294 ALA ALA A . n 
A 1 177 GLU 177 295 295 GLU GLU A . n 
A 1 178 THR 178 296 296 THR THR A . n 
A 1 179 GLY 179 297 297 GLY GLY A . n 
A 1 180 THR 180 298 298 THR THR A . n 
A 1 181 TRP 181 299 299 TRP TRP A . n 
A 1 182 GLU 182 300 300 GLU GLU A . n 
A 1 183 CYS 183 301 301 CYS CYS A . n 
A 1 184 GLY 184 302 302 GLY GLY A . n 
A 1 185 ARG 185 303 303 ARG ARG A . n 
A 1 186 LEU 186 304 304 LEU LEU A . n 
A 1 187 SER 187 305 305 SER SER A . n 
A 1 188 TYR 188 306 306 TYR TYR A . n 
A 1 189 CYS 189 307 307 CYS CYS A . n 
A 1 190 LEU 190 308 308 LEU LEU A . n 
A 1 191 GLU 191 309 309 GLU GLU A . n 
A 1 192 ASP 192 310 310 ASP ASP A . n 
A 1 193 THR 193 311 ?   ?   ?   A . n 
A 1 194 ALA 194 312 ?   ?   ?   A . n 
A 1 195 GLY 195 313 ?   ?   ?   A . n 
A 1 196 GLY 196 314 ?   ?   ?   A . n 
A 1 197 PHE 197 315 315 PHE PHE A . n 
A 1 198 GLN 198 316 316 GLN GLN A . n 
A 1 199 GLN 199 317 317 GLN GLN A . n 
A 1 200 LEU 200 318 318 LEU LEU A . n 
A 1 201 LEU 201 319 319 LEU LEU A . n 
A 1 202 LEU 202 320 320 LEU LEU A . n 
A 1 203 GLU 203 321 321 GLU GLU A . n 
A 1 204 PRO 204 322 322 PRO PRO A . n 
A 1 205 MET 205 323 323 MET MET A . n 
A 1 206 LEU 206 324 324 LEU LEU A . n 
A 1 207 LYS 207 325 325 LYS LYS A . n 
A 1 208 PHE 208 326 326 PHE PHE A . n 
A 1 209 HIS 209 327 327 HIS HIS A . n 
A 1 210 TYR 210 328 328 TYR TYR A . n 
A 1 211 MET 211 329 329 MET MET A . n 
A 1 212 LEU 212 330 330 LEU LEU A . n 
A 1 213 LYS 213 331 331 LYS LYS A . n 
A 1 214 LYS 214 332 332 LYS LYS A . n 
A 1 215 LEU 215 333 333 LEU LEU A . n 
A 1 216 GLN 216 334 334 GLN GLN A . n 
A 1 217 LEU 217 335 335 LEU LEU A . n 
A 1 218 HIS 218 336 336 HIS HIS A . n 
A 1 219 GLU 219 337 337 GLU GLU A . n 
A 1 220 GLU 220 338 338 GLU GLU A . n 
A 1 221 GLU 221 339 339 GLU GLU A . n 
A 1 222 TYR 222 340 340 TYR TYR A . n 
A 1 223 VAL 223 341 341 VAL VAL A . n 
A 1 224 LEU 224 342 342 LEU LEU A . n 
A 1 225 MET 225 343 343 MET MET A . n 
A 1 226 GLN 226 344 344 GLN GLN A . n 
A 1 227 ALA 227 345 345 ALA ALA A . n 
A 1 228 ILE 228 346 346 ILE ILE A . n 
A 1 229 SER 229 347 347 SER SER A . n 
A 1 230 LEU 230 348 348 LEU LEU A . n 
A 1 231 PHE 231 349 349 PHE PHE A . n 
A 1 232 SER 232 350 350 SER SER A . n 
A 1 233 PRO 233 351 351 PRO PRO A . n 
A 1 234 ASP 234 352 352 ASP ASP A . n 
A 1 235 ARG 235 353 353 ARG ARG A . n 
A 1 236 PRO 236 354 354 PRO PRO A . n 
A 1 237 GLY 237 355 355 GLY GLY A . n 
A 1 238 VAL 238 356 356 VAL VAL A . n 
A 1 239 LEU 239 357 357 LEU LEU A . n 
A 1 240 GLN 240 358 358 GLN GLN A . n 
A 1 241 HIS 241 359 359 HIS HIS A . n 
A 1 242 ARG 242 360 360 ARG ARG A . n 
A 1 243 VAL 243 361 361 VAL VAL A . n 
A 1 244 VAL 244 362 362 VAL VAL A . n 
A 1 245 ASP 245 363 363 ASP ASP A . n 
A 1 246 GLN 246 364 364 GLN GLN A . n 
A 1 247 LEU 247 365 365 LEU LEU A . n 
A 1 248 GLN 248 366 366 GLN GLN A . n 
A 1 249 GLU 249 367 367 GLU GLU A . n 
A 1 250 GLN 250 368 368 GLN GLN A . n 
A 1 251 PHE 251 369 369 PHE PHE A . n 
A 1 252 ALA 252 370 370 ALA ALA A . n 
A 1 253 ILE 253 371 371 ILE ILE A . n 
A 1 254 THR 254 372 372 THR THR A . n 
A 1 255 LEU 255 373 373 LEU LEU A . n 
A 1 256 LYS 256 374 374 LYS LYS A . n 
A 1 257 SER 257 375 375 SER SER A . n 
A 1 258 TYR 258 376 376 TYR TYR A . n 
A 1 259 ILE 259 377 377 ILE ILE A . n 
A 1 260 GLU 260 378 378 GLU GLU A . n 
A 1 261 CYS 261 379 379 CYS CYS A . n 
A 1 262 ASN 262 380 380 ASN ASN A . n 
A 1 263 ARG 263 381 381 ARG ARG A . n 
A 1 264 PRO 264 382 382 PRO PRO A . n 
A 1 265 GLN 265 383 383 GLN GLN A . n 
A 1 266 PRO 266 384 384 PRO PRO A . n 
A 1 267 ALA 267 385 385 ALA ALA A . n 
A 1 268 HIS 268 386 386 HIS HIS A . n 
A 1 269 ARG 269 387 387 ARG ARG A . n 
A 1 270 PHE 270 388 388 PHE PHE A . n 
A 1 271 LEU 271 389 389 LEU LEU A . n 
A 1 272 PHE 272 390 390 PHE PHE A . n 
A 1 273 LEU 273 391 391 LEU LEU A . n 
A 1 274 LYS 274 392 392 LYS LYS A . n 
A 1 275 ILE 275 393 393 ILE ILE A . n 
A 1 276 MET 276 394 394 MET MET A . n 
A 1 277 ALA 277 395 395 ALA ALA A . n 
A 1 278 MET 278 396 396 MET MET A . n 
A 1 279 LEU 279 397 397 LEU LEU A . n 
A 1 280 THR 280 398 398 THR THR A . n 
A 1 281 GLU 281 399 399 GLU GLU A . n 
A 1 282 LEU 282 400 400 LEU LEU A . n 
A 1 283 ARG 283 401 401 ARG ARG A . n 
A 1 284 SER 284 402 402 SER SER A . n 
A 1 285 ILE 285 403 403 ILE ILE A . n 
A 1 286 ASN 286 404 404 ASN ASN A . n 
A 1 287 ALA 287 405 405 ALA ALA A . n 
A 1 288 GLN 288 406 406 GLN GLN A . n 
A 1 289 HIS 289 407 407 HIS HIS A . n 
A 1 290 THR 290 408 408 THR THR A . n 
A 1 291 GLN 291 409 409 GLN GLN A . n 
A 1 292 ARG 292 410 410 ARG ARG A . n 
A 1 293 LEU 293 411 411 LEU LEU A . n 
A 1 294 LEU 294 412 412 LEU LEU A . n 
A 1 295 ARG 295 413 413 ARG ARG A . n 
A 1 296 ILE 296 414 414 ILE ILE A . n 
A 1 297 GLN 297 415 415 GLN GLN A . n 
A 1 298 ASP 298 416 416 ASP ASP A . n 
A 1 299 ILE 299 417 417 ILE ILE A . n 
A 1 300 HIS 300 418 418 HIS HIS A . n 
A 1 301 PRO 301 419 419 PRO PRO A . n 
A 1 302 PHE 302 420 420 PHE PHE A . n 
A 1 303 ALA 303 421 421 ALA ALA A . n 
A 1 304 THR 304 422 422 THR THR A . n 
A 1 305 PRO 305 423 423 PRO PRO A . n 
A 1 306 LEU 306 424 424 LEU LEU A . n 
A 1 307 MET 307 425 425 MET MET A . n 
A 1 308 GLN 308 426 426 GLN GLN A . n 
A 1 309 GLU 309 427 427 GLU GLU A . n 
A 1 310 LEU 310 428 428 LEU LEU A . n 
A 1 311 PHE 311 429 429 PHE PHE A . n 
A 1 312 GLY 312 430 430 GLY GLY A . n 
A 1 313 ILE 313 431 431 ILE ILE A . n 
A 1 314 THR 314 432 432 THR THR A . n 
A 1 315 GLY 315 433 433 GLY GLY A . n 
A 1 316 SER 316 434 434 SER SER A . n 
A 1 317 LEU 317 435 ?   ?   ?   A . n 
A 1 318 VAL 318 436 ?   ?   ?   A . n 
A 1 319 PRO 319 437 ?   ?   ?   A . n 
A 1 320 ARG 320 438 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1IHA 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1IHA 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1IHA 1   501 1   A1IHA 035 A . 
C 3 GOL   1   502 1   GOL   GOL A . 
D 3 GOL   1   503 3   GOL   GOL A . 
E 4 IPA   1   504 1   IPA   IPA A . 
F 4 IPA   1   505 2   IPA   IPA A . 
G 5 HOH   1   601 71  HOH   HOH A . 
G 5 HOH   2   602 134 HOH   HOH A . 
G 5 HOH   3   603 162 HOH   HOH A . 
G 5 HOH   4   604 57  HOH   HOH A . 
G 5 HOH   5   605 179 HOH   HOH A . 
G 5 HOH   6   606 189 HOH   HOH A . 
G 5 HOH   7   607 58  HOH   HOH A . 
G 5 HOH   8   608 17  HOH   HOH A . 
G 5 HOH   9   609 216 HOH   HOH A . 
G 5 HOH   10  610 123 HOH   HOH A . 
G 5 HOH   11  611 88  HOH   HOH A . 
G 5 HOH   12  612 199 HOH   HOH A . 
G 5 HOH   13  613 74  HOH   HOH A . 
G 5 HOH   14  614 96  HOH   HOH A . 
G 5 HOH   15  615 28  HOH   HOH A . 
G 5 HOH   16  616 59  HOH   HOH A . 
G 5 HOH   17  617 43  HOH   HOH A . 
G 5 HOH   18  618 118 HOH   HOH A . 
G 5 HOH   19  619 209 HOH   HOH A . 
G 5 HOH   20  620 159 HOH   HOH A . 
G 5 HOH   21  621 78  HOH   HOH A . 
G 5 HOH   22  622 40  HOH   HOH A . 
G 5 HOH   23  623 108 HOH   HOH A . 
G 5 HOH   24  624 37  HOH   HOH A . 
G 5 HOH   25  625 61  HOH   HOH A . 
G 5 HOH   26  626 161 HOH   HOH A . 
G 5 HOH   27  627 158 HOH   HOH A . 
G 5 HOH   28  628 62  HOH   HOH A . 
G 5 HOH   29  629 4   HOH   HOH A . 
G 5 HOH   30  630 98  HOH   HOH A . 
G 5 HOH   31  631 113 HOH   HOH A . 
G 5 HOH   32  632 86  HOH   HOH A . 
G 5 HOH   33  633 100 HOH   HOH A . 
G 5 HOH   34  634 21  HOH   HOH A . 
G 5 HOH   35  635 33  HOH   HOH A . 
G 5 HOH   36  636 138 HOH   HOH A . 
G 5 HOH   37  637 181 HOH   HOH A . 
G 5 HOH   38  638 64  HOH   HOH A . 
G 5 HOH   39  639 38  HOH   HOH A . 
G 5 HOH   40  640 97  HOH   HOH A . 
G 5 HOH   41  641 24  HOH   HOH A . 
G 5 HOH   42  642 6   HOH   HOH A . 
G 5 HOH   43  643 130 HOH   HOH A . 
G 5 HOH   44  644 185 HOH   HOH A . 
G 5 HOH   45  645 5   HOH   HOH A . 
G 5 HOH   46  646 10  HOH   HOH A . 
G 5 HOH   47  647 31  HOH   HOH A . 
G 5 HOH   48  648 15  HOH   HOH A . 
G 5 HOH   49  649 156 HOH   HOH A . 
G 5 HOH   50  650 79  HOH   HOH A . 
G 5 HOH   51  651 2   HOH   HOH A . 
G 5 HOH   52  652 54  HOH   HOH A . 
G 5 HOH   53  653 124 HOH   HOH A . 
G 5 HOH   54  654 73  HOH   HOH A . 
G 5 HOH   55  655 3   HOH   HOH A . 
G 5 HOH   56  656 193 HOH   HOH A . 
G 5 HOH   57  657 41  HOH   HOH A . 
G 5 HOH   58  658 95  HOH   HOH A . 
G 5 HOH   59  659 117 HOH   HOH A . 
G 5 HOH   60  660 25  HOH   HOH A . 
G 5 HOH   61  661 20  HOH   HOH A . 
G 5 HOH   62  662 51  HOH   HOH A . 
G 5 HOH   63  663 131 HOH   HOH A . 
G 5 HOH   64  664 22  HOH   HOH A . 
G 5 HOH   65  665 66  HOH   HOH A . 
G 5 HOH   66  666 7   HOH   HOH A . 
G 5 HOH   67  667 45  HOH   HOH A . 
G 5 HOH   68  668 207 HOH   HOH A . 
G 5 HOH   69  669 111 HOH   HOH A . 
G 5 HOH   70  670 46  HOH   HOH A . 
G 5 HOH   71  671 30  HOH   HOH A . 
G 5 HOH   72  672 208 HOH   HOH A . 
G 5 HOH   73  673 151 HOH   HOH A . 
G 5 HOH   74  674 133 HOH   HOH A . 
G 5 HOH   75  675 81  HOH   HOH A . 
G 5 HOH   76  676 182 HOH   HOH A . 
G 5 HOH   77  677 56  HOH   HOH A . 
G 5 HOH   78  678 34  HOH   HOH A . 
G 5 HOH   79  679 83  HOH   HOH A . 
G 5 HOH   80  680 149 HOH   HOH A . 
G 5 HOH   81  681 168 HOH   HOH A . 
G 5 HOH   82  682 202 HOH   HOH A . 
G 5 HOH   83  683 19  HOH   HOH A . 
G 5 HOH   84  684 11  HOH   HOH A . 
G 5 HOH   85  685 170 HOH   HOH A . 
G 5 HOH   86  686 68  HOH   HOH A . 
G 5 HOH   87  687 196 HOH   HOH A . 
G 5 HOH   88  688 148 HOH   HOH A . 
G 5 HOH   89  689 174 HOH   HOH A . 
G 5 HOH   90  690 211 HOH   HOH A . 
G 5 HOH   91  691 187 HOH   HOH A . 
G 5 HOH   92  692 183 HOH   HOH A . 
G 5 HOH   93  693 18  HOH   HOH A . 
G 5 HOH   94  694 16  HOH   HOH A . 
G 5 HOH   95  695 165 HOH   HOH A . 
G 5 HOH   96  696 160 HOH   HOH A . 
G 5 HOH   97  697 13  HOH   HOH A . 
G 5 HOH   98  698 44  HOH   HOH A . 
G 5 HOH   99  699 39  HOH   HOH A . 
G 5 HOH   100 700 140 HOH   HOH A . 
G 5 HOH   101 701 116 HOH   HOH A . 
G 5 HOH   102 702 205 HOH   HOH A . 
G 5 HOH   103 703 166 HOH   HOH A . 
G 5 HOH   104 704 9   HOH   HOH A . 
G 5 HOH   105 705 203 HOH   HOH A . 
G 5 HOH   106 706 53  HOH   HOH A . 
G 5 HOH   107 707 194 HOH   HOH A . 
G 5 HOH   108 708 105 HOH   HOH A . 
G 5 HOH   109 709 65  HOH   HOH A . 
G 5 HOH   110 710 218 HOH   HOH A . 
G 5 HOH   111 711 120 HOH   HOH A . 
G 5 HOH   112 712 67  HOH   HOH A . 
G 5 HOH   113 713 125 HOH   HOH A . 
G 5 HOH   114 714 152 HOH   HOH A . 
G 5 HOH   115 715 198 HOH   HOH A . 
G 5 HOH   116 716 107 HOH   HOH A . 
G 5 HOH   117 717 173 HOH   HOH A . 
G 5 HOH   118 718 119 HOH   HOH A . 
G 5 HOH   119 719 82  HOH   HOH A . 
G 5 HOH   120 720 14  HOH   HOH A . 
G 5 HOH   121 721 186 HOH   HOH A . 
G 5 HOH   122 722 163 HOH   HOH A . 
G 5 HOH   123 723 213 HOH   HOH A . 
G 5 HOH   124 724 23  HOH   HOH A . 
G 5 HOH   125 725 49  HOH   HOH A . 
G 5 HOH   126 726 85  HOH   HOH A . 
G 5 HOH   127 727 180 HOH   HOH A . 
G 5 HOH   128 728 154 HOH   HOH A . 
G 5 HOH   129 729 12  HOH   HOH A . 
G 5 HOH   130 730 94  HOH   HOH A . 
G 5 HOH   131 731 50  HOH   HOH A . 
G 5 HOH   132 732 8   HOH   HOH A . 
G 5 HOH   133 733 192 HOH   HOH A . 
G 5 HOH   134 734 90  HOH   HOH A . 
G 5 HOH   135 735 99  HOH   HOH A . 
G 5 HOH   136 736 221 HOH   HOH A . 
G 5 HOH   137 737 201 HOH   HOH A . 
G 5 HOH   138 738 109 HOH   HOH A . 
G 5 HOH   139 739 145 HOH   HOH A . 
G 5 HOH   140 740 214 HOH   HOH A . 
G 5 HOH   141 741 147 HOH   HOH A . 
G 5 HOH   142 742 63  HOH   HOH A . 
G 5 HOH   143 743 223 HOH   HOH A . 
G 5 HOH   144 744 137 HOH   HOH A . 
G 5 HOH   145 745 72  HOH   HOH A . 
G 5 HOH   146 746 101 HOH   HOH A . 
G 5 HOH   147 747 191 HOH   HOH A . 
G 5 HOH   148 748 175 HOH   HOH A . 
G 5 HOH   149 749 204 HOH   HOH A . 
G 5 HOH   150 750 178 HOH   HOH A . 
G 5 HOH   151 751 27  HOH   HOH A . 
G 5 HOH   152 752 146 HOH   HOH A . 
G 5 HOH   153 753 89  HOH   HOH A . 
G 5 HOH   154 754 110 HOH   HOH A . 
G 5 HOH   155 755 153 HOH   HOH A . 
G 5 HOH   156 756 69  HOH   HOH A . 
G 5 HOH   157 757 169 HOH   HOH A . 
G 5 HOH   158 758 114 HOH   HOH A . 
G 5 HOH   159 759 220 HOH   HOH A . 
G 5 HOH   160 760 217 HOH   HOH A . 
G 5 HOH   161 761 126 HOH   HOH A . 
G 5 HOH   162 762 84  HOH   HOH A . 
G 5 HOH   163 763 48  HOH   HOH A . 
G 5 HOH   164 764 122 HOH   HOH A . 
G 5 HOH   165 765 127 HOH   HOH A . 
G 5 HOH   166 766 184 HOH   HOH A . 
G 5 HOH   167 767 215 HOH   HOH A . 
G 5 HOH   168 768 222 HOH   HOH A . 
G 5 HOH   169 769 139 HOH   HOH A . 
G 5 HOH   170 770 177 HOH   HOH A . 
G 5 HOH   171 771 55  HOH   HOH A . 
G 5 HOH   172 772 150 HOH   HOH A . 
G 5 HOH   173 773 77  HOH   HOH A . 
G 5 HOH   174 774 32  HOH   HOH A . 
G 5 HOH   175 775 155 HOH   HOH A . 
G 5 HOH   176 776 70  HOH   HOH A . 
G 5 HOH   177 777 42  HOH   HOH A . 
G 5 HOH   178 778 102 HOH   HOH A . 
G 5 HOH   179 779 80  HOH   HOH A . 
G 5 HOH   180 780 195 HOH   HOH A . 
G 5 HOH   181 781 141 HOH   HOH A . 
G 5 HOH   182 782 76  HOH   HOH A . 
G 5 HOH   183 783 188 HOH   HOH A . 
G 5 HOH   184 784 121 HOH   HOH A . 
G 5 HOH   185 785 103 HOH   HOH A . 
G 5 HOH   186 786 164 HOH   HOH A . 
G 5 HOH   187 787 171 HOH   HOH A . 
G 5 HOH   188 788 206 HOH   HOH A . 
G 5 HOH   189 789 112 HOH   HOH A . 
G 5 HOH   190 790 190 HOH   HOH A . 
G 5 HOH   191 791 219 HOH   HOH A . 
G 5 HOH   192 792 115 HOH   HOH A . 
G 5 HOH   193 793 136 HOH   HOH A . 
G 5 HOH   194 794 92  HOH   HOH A . 
G 5 HOH   195 795 144 HOH   HOH A . 
G 5 HOH   196 796 224 HOH   HOH A . 
G 5 HOH   197 797 200 HOH   HOH A . 
G 5 HOH   198 798 104 HOH   HOH A . 
G 5 HOH   199 799 197 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 146 ? CG  ? A GLU 28  CG  
2  1 Y 1 A GLU 146 ? CD  ? A GLU 28  CD  
3  1 Y 1 A GLU 146 ? OE1 ? A GLU 28  OE1 
4  1 Y 1 A GLU 146 ? OE2 ? A GLU 28  OE2 
5  1 Y 1 A ARG 152 ? CG  ? A ARG 34  CG  
6  1 Y 1 A ARG 152 ? CD  ? A ARG 34  CD  
7  1 Y 1 A ARG 152 ? NE  ? A ARG 34  NE  
8  1 Y 1 A ARG 152 ? CZ  ? A ARG 34  CZ  
9  1 Y 1 A ARG 152 ? NH1 ? A ARG 34  NH1 
10 1 Y 1 A ARG 152 ? NH2 ? A ARG 34  NH2 
11 1 Y 1 A VAL 177 ? CG1 ? A VAL 59  CG1 
12 1 Y 1 A VAL 177 ? CG2 ? A VAL 59  CG2 
13 1 Y 1 A SER 208 ? OG  ? A SER 90  OG  
14 1 Y 1 A LEU 209 ? CG  ? A LEU 91  CG  
15 1 Y 1 A LEU 209 ? CD1 ? A LEU 91  CD1 
16 1 Y 1 A LEU 209 ? CD2 ? A LEU 91  CD2 
17 1 Y 1 A LYS 210 ? CD  ? A LYS 92  CD  
18 1 Y 1 A LYS 210 ? CE  ? A LYS 92  CE  
19 1 Y 1 A LYS 210 ? NZ  ? A LYS 92  NZ  
20 1 Y 1 A GLU 218 ? CG  ? A GLU 100 CG  
21 1 Y 1 A GLU 218 ? CD  ? A GLU 100 CD  
22 1 Y 1 A GLU 218 ? OE1 ? A GLU 100 OE1 
23 1 Y 1 A GLU 218 ? OE2 ? A GLU 100 OE2 
24 1 Y 1 A LYS 226 ? CD  ? A LYS 108 CD  
25 1 Y 1 A LYS 226 ? CE  ? A LYS 108 CE  
26 1 Y 1 A LYS 226 ? NZ  ? A LYS 108 NZ  
27 1 Y 1 A SER 231 ? OG  ? A SER 113 OG  
28 1 Y 1 A LYS 234 ? CG  ? A LYS 116 CG  
29 1 Y 1 A LYS 234 ? CD  ? A LYS 116 CD  
30 1 Y 1 A LYS 234 ? CE  ? A LYS 116 CE  
31 1 Y 1 A LYS 234 ? NZ  ? A LYS 116 NZ  
32 1 Y 1 A LYS 259 ? CE  ? A LYS 141 CE  
33 1 Y 1 A LYS 259 ? NZ  ? A LYS 141 NZ  
34 1 Y 1 A ARG 303 ? CG  ? A ARG 185 CG  
35 1 Y 1 A ARG 303 ? CD  ? A ARG 185 CD  
36 1 Y 1 A ARG 303 ? NE  ? A ARG 185 NE  
37 1 Y 1 A ARG 303 ? CZ  ? A ARG 185 CZ  
38 1 Y 1 A ARG 303 ? NH1 ? A ARG 185 NH1 
39 1 Y 1 A ARG 303 ? NH2 ? A ARG 185 NH2 
40 1 Y 1 A ASP 310 ? CG  ? A ASP 192 CG  
41 1 Y 1 A ASP 310 ? OD1 ? A ASP 192 OD1 
42 1 Y 1 A ASP 310 ? OD2 ? A ASP 192 OD2 
43 1 Y 1 A PHE 315 ? CG  ? A PHE 197 CG  
44 1 Y 1 A PHE 315 ? CD1 ? A PHE 197 CD1 
45 1 Y 1 A PHE 315 ? CD2 ? A PHE 197 CD2 
46 1 Y 1 A PHE 315 ? CE1 ? A PHE 197 CE1 
47 1 Y 1 A PHE 315 ? CE2 ? A PHE 197 CE2 
48 1 Y 1 A PHE 315 ? CZ  ? A PHE 197 CZ  
49 1 Y 1 A GLN 316 ? CG  ? A GLN 198 CG  
50 1 Y 1 A GLN 316 ? CD  ? A GLN 198 CD  
51 1 Y 1 A GLN 316 ? OE1 ? A GLN 198 OE1 
52 1 Y 1 A GLN 316 ? NE2 ? A GLN 198 NE2 
53 1 Y 1 A GLN 317 ? CG  ? A GLN 199 CG  
54 1 Y 1 A GLN 317 ? CD  ? A GLN 199 CD  
55 1 Y 1 A GLN 317 ? OE1 ? A GLN 199 OE1 
56 1 Y 1 A GLN 317 ? NE2 ? A GLN 199 NE2 
57 1 Y 1 A LEU 318 ? CG  ? A LEU 200 CG  
58 1 Y 1 A LEU 318 ? CD1 ? A LEU 200 CD1 
59 1 Y 1 A LEU 318 ? CD2 ? A LEU 200 CD2 
60 1 Y 1 A LYS 325 ? CE  ? A LYS 207 CE  
61 1 Y 1 A LYS 325 ? NZ  ? A LYS 207 NZ  
62 1 Y 1 A LYS 332 ? CE  ? A LYS 214 CE  
63 1 Y 1 A LYS 332 ? NZ  ? A LYS 214 NZ  
64 1 Y 1 A ARG 360 ? CG  ? A ARG 242 CG  
65 1 Y 1 A ARG 360 ? CD  ? A ARG 242 CD  
66 1 Y 1 A ARG 360 ? NE  ? A ARG 242 NE  
67 1 Y 1 A ARG 360 ? CZ  ? A ARG 242 CZ  
68 1 Y 1 A ARG 360 ? NH1 ? A ARG 242 NH1 
69 1 Y 1 A ARG 360 ? NH2 ? A ARG 242 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.18.2_3874 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FZG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     91.040 
_cell.length_a_esd                 ? 
_cell.length_b                     91.040 
_cell.length_b_esd                 ? 
_cell.length_c                     86.600 
_cell.length_c_esd                 ? 
_cell.volume                       717765.188 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FZG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FZG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.44 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.62 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;50 - 100 mM imidazole
8 - 14% isopropanol
;
_exptl_crystal_grow.pdbx_pH_range   '7.0 - 7.4' 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2018-11-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979334 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979334 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          33.02 
_reflns.entry_id                                       9FZG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               40.71 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25135 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          28.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.046 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.56 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1814 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               8.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.927 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               0.534 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               37.64 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FZG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             40.71 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25129 
_refine.ls_number_reflns_R_free                  1256 
_refine.ls_number_reflns_R_work                  23873 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.76 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1935 
_refine.ls_R_factor_R_free                       0.2369 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1913 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.6138 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2176 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        40.71 
_refine_hist.number_atoms_solvent             199 
_refine_hist.number_atoms_total               2321 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2042 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         80 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0083 ? 2191 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9602 ? 2963 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0509 ? 324  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0061 ? 402  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.9712 ? 346  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.08  . . 135 2594 99.85  . . . . 0.2379 . . . . . . . . . . . 0.2862 
'X-RAY DIFFRACTION' 2.08 2.17  . . 138 2617 99.96  . . . . 0.2045 . . . . . . . . . . . 0.2764 
'X-RAY DIFFRACTION' 2.17 2.29  . . 137 2598 99.85  . . . . 0.2145 . . . . . . . . . . . 0.2884 
'X-RAY DIFFRACTION' 2.29 2.43  . . 138 2616 99.96  . . . . 0.1926 . . . . . . . . . . . 0.2424 
'X-RAY DIFFRACTION' 2.43 2.62  . . 139 2643 100.00 . . . . 0.2074 . . . . . . . . . . . 0.3118 
'X-RAY DIFFRACTION' 2.62 2.88  . . 138 2630 99.93  . . . . 0.1967 . . . . . . . . . . . 0.2513 
'X-RAY DIFFRACTION' 2.88 3.30  . . 141 2674 99.82  . . . . 0.1985 . . . . . . . . . . . 0.2528 
'X-RAY DIFFRACTION' 3.30 4.16  . . 141 2687 99.75  . . . . 0.1738 . . . . . . . . . . . 0.2001 
'X-RAY DIFFRACTION' 4.16 40.71 . . 149 2814 98.93  . . . . 0.1834 . . . . . . . . . . . 0.2136 
# 
_struct.entry_id                     9FZG 
_struct.title                        'Crystal structure of the hPXR-LBD in complex with compound JMV7035' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FZG 
_struct_keywords.text            'nuclear receptor, ligand binding domain, PXR, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NR1I2_HUMAN 
_struct_ref.pdbx_db_accession          O75469 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSL
KVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFN
TVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQF
AITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
;
_struct_ref.pdbx_align_begin           130 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FZG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 12 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 316 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O75469 
_struct_ref_seq.db_align_beg                  130 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  434 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       130 
_struct_ref_seq.pdbx_auth_seq_align_end       434 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FZG MET A 1   ? UNP O75469 ? ? 'initiating methionine' 119 1  
1 9FZG LYS A 2   ? UNP O75469 ? ? 'expression tag'        120 2  
1 9FZG LYS A 3   ? UNP O75469 ? ? 'expression tag'        121 3  
1 9FZG GLY A 4   ? UNP O75469 ? ? 'expression tag'        122 4  
1 9FZG HIS A 5   ? UNP O75469 ? ? 'expression tag'        123 5  
1 9FZG HIS A 6   ? UNP O75469 ? ? 'expression tag'        124 6  
1 9FZG HIS A 7   ? UNP O75469 ? ? 'expression tag'        125 7  
1 9FZG HIS A 8   ? UNP O75469 ? ? 'expression tag'        126 8  
1 9FZG HIS A 9   ? UNP O75469 ? ? 'expression tag'        127 9  
1 9FZG HIS A 10  ? UNP O75469 ? ? 'expression tag'        128 10 
1 9FZG GLY A 11  ? UNP O75469 ? ? 'expression tag'        129 11 
1 9FZG LEU A 317 ? UNP O75469 ? ? 'expression tag'        435 12 
1 9FZG VAL A 318 ? UNP O75469 ? ? 'expression tag'        436 13 
1 9FZG PRO A 319 ? UNP O75469 ? ? 'expression tag'        437 14 
1 9FZG ARG A 320 ? UNP O75469 ? ? 'expression tag'        438 15 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 780   ? 
1 MORE         6     ? 
1 'SSA (A^2)'  12990 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 26  ? PHE A 44  ? THR A 144 PHE A 162 1 ? 19 
HELX_P HELX_P2  AA2 GLY A 115 ? SER A 120 ? GLY A 233 SER A 238 5 ? 6  
HELX_P HELX_P3  AA3 LEU A 121 ? ILE A 143 ? LEU A 239 ILE A 261 1 ? 23 
HELX_P HELX_P4  AA4 ILE A 143 ? ASP A 148 ? ILE A 261 ASP A 266 1 ? 6  
HELX_P HELX_P5  AA5 PRO A 150 ? VAL A 173 ? PRO A 268 VAL A 291 1 ? 24 
HELX_P HELX_P6  AA6 GLU A 203 ? LEU A 215 ? GLU A 321 LEU A 333 1 ? 13 
HELX_P HELX_P7  AA7 HIS A 218 ? PHE A 231 ? HIS A 336 PHE A 349 1 ? 14 
HELX_P HELX_P8  AA8 GLN A 240 ? ARG A 263 ? GLN A 358 ARG A 381 1 ? 24 
HELX_P HELX_P9  AA9 GLN A 265 ? ARG A 269 ? GLN A 383 ARG A 387 5 ? 5  
HELX_P HELX_P10 AB1 PHE A 270 ? HIS A 300 ? PHE A 388 HIS A 418 1 ? 31 
HELX_P HELX_P11 AB2 THR A 304 ? GLY A 312 ? THR A 422 GLY A 430 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   5 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 104 ? TYR A 107 ? VAL A 222 TYR A 225 
AA1 2 VAL A 93  ? ARG A 98  ? VAL A 211 ARG A 216 
AA1 3 LEU A 186 ? LEU A 190 ? LEU A 304 LEU A 308 
AA1 4 THR A 180 ? CYS A 183 ? THR A 298 CYS A 301 
AA1 5 PHE A 174 ? ASN A 175 ? PHE A 292 ASN A 293 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TYR A 107 ? O TYR A 225 N LEU A 95  ? N LEU A 213 
AA1 2 3 N GLN A 96  ? N GLN A 214 O SER A 187 ? O SER A 305 
AA1 3 4 O LEU A 186 ? O LEU A 304 N CYS A 183 ? N CYS A 301 
AA1 4 5 O THR A 180 ? O THR A 298 N ASN A 175 ? N ASN A 293 
# 
_pdbx_entry_details.entry_id                   9FZG 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 163 ? ? O   A HOH 601 ? ? 2.09 
2 1 NE2 A GLN 368 ? A O   A HOH 602 ? ? 2.09 
3 1 O   A HOH 716 ? ? O   A HOH 748 ? ? 2.10 
4 1 O   A HOH 719 ? ? O   A HOH 772 ? ? 2.16 
5 1 OD1 A ASP 352 ? ? NH1 A ARG 401 ? B 2.16 
6 1 OE2 A GLU 153 ? ? O   A HOH 603 ? ? 2.17 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     678 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     687 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_455 
_pdbx_validate_symm_contact.dist              2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 301 ? ? -109.24 69.57  
2 1 PHE A 349 ? ? -92.62  59.02  
3 1 HIS A 418 ? ? -153.04 86.00  
4 1 PHE A 420 ? ? -152.10 -16.86 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       799 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.93 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 119 ? A MET 1   
2  1 Y 1 A LYS 120 ? A LYS 2   
3  1 Y 1 A LYS 121 ? A LYS 3   
4  1 Y 1 A GLY 122 ? A GLY 4   
5  1 Y 1 A HIS 123 ? A HIS 5   
6  1 Y 1 A HIS 124 ? A HIS 6   
7  1 Y 1 A HIS 125 ? A HIS 7   
8  1 Y 1 A HIS 126 ? A HIS 8   
9  1 Y 1 A HIS 127 ? A HIS 9   
10 1 Y 1 A HIS 128 ? A HIS 10  
11 1 Y 1 A GLY 129 ? A GLY 11  
12 1 Y 1 A SER 130 ? A SER 12  
13 1 Y 1 A GLU 131 ? A GLU 13  
14 1 Y 1 A ARG 132 ? A ARG 14  
15 1 Y 1 A THR 133 ? A THR 15  
16 1 Y 1 A GLY 134 ? A GLY 16  
17 1 Y 1 A THR 135 ? A THR 17  
18 1 Y 1 A GLN 136 ? A GLN 18  
19 1 Y 1 A PRO 137 ? A PRO 19  
20 1 Y 1 A LEU 138 ? A LEU 20  
21 1 Y 1 A GLY 139 ? A GLY 21  
22 1 Y 1 A VAL 140 ? A VAL 22  
23 1 Y 1 A GLN 141 ? A GLN 23  
24 1 Y 1 A LEU 178 ? A LEU 60  
25 1 Y 1 A SER 179 ? A SER 61  
26 1 Y 1 A SER 180 ? A SER 62  
27 1 Y 1 A GLY 181 ? A GLY 63  
28 1 Y 1 A CYS 182 ? A CYS 64  
29 1 Y 1 A GLU 183 ? A GLU 65  
30 1 Y 1 A LEU 184 ? A LEU 66  
31 1 Y 1 A PRO 185 ? A PRO 67  
32 1 Y 1 A GLU 186 ? A GLU 68  
33 1 Y 1 A SER 187 ? A SER 69  
34 1 Y 1 A LEU 188 ? A LEU 70  
35 1 Y 1 A GLN 189 ? A GLN 71  
36 1 Y 1 A ALA 190 ? A ALA 72  
37 1 Y 1 A PRO 191 ? A PRO 73  
38 1 Y 1 A SER 192 ? A SER 74  
39 1 Y 1 A ARG 193 ? A ARG 75  
40 1 Y 1 A GLU 194 ? A GLU 76  
41 1 Y 1 A GLU 195 ? A GLU 77  
42 1 Y 1 A ALA 196 ? A ALA 78  
43 1 Y 1 A ALA 197 ? A ALA 79  
44 1 Y 1 A LYS 198 ? A LYS 80  
45 1 Y 1 A TRP 199 ? A TRP 81  
46 1 Y 1 A SER 200 ? A SER 82  
47 1 Y 1 A GLN 201 ? A GLN 83  
48 1 Y 1 A VAL 202 ? A VAL 84  
49 1 Y 1 A ARG 203 ? A ARG 85  
50 1 Y 1 A LYS 204 ? A LYS 86  
51 1 Y 1 A ASP 205 ? A ASP 87  
52 1 Y 1 A LEU 206 ? A LEU 88  
53 1 Y 1 A CYS 207 ? A CYS 89  
54 1 Y 1 A THR 311 ? A THR 193 
55 1 Y 1 A ALA 312 ? A ALA 194 
56 1 Y 1 A GLY 313 ? A GLY 195 
57 1 Y 1 A GLY 314 ? A GLY 196 
58 1 Y 1 A LEU 435 ? A LEU 317 
59 1 Y 1 A VAL 436 ? A VAL 318 
60 1 Y 1 A PRO 437 ? A PRO 319 
61 1 Y 1 A ARG 438 ? A ARG 320 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1IHA C1   C Y N 1   
A1IHA C2   C Y N 2   
A1IHA C3   C Y N 3   
A1IHA C4   C N N 4   
A1IHA C5   C Y N 5   
A1IHA C6   C Y N 6   
A1IHA C7   C Y N 7   
A1IHA N    N N N 8   
A1IHA C    C N N 9   
A1IHA O    O N N 10  
A1IHA C10  C Y N 11  
A1IHA C11  C Y N 12  
A1IHA C12  C Y N 13  
A1IHA C13  C N N 14  
A1IHA C14  C N N 15  
A1IHA C15  C N N 16  
A1IHA C16  C N N 17  
A1IHA C17  C N N 18  
A1IHA C18  C N N 19  
A1IHA C19  C N N 20  
A1IHA C20  C N N 21  
A1IHA C21  C N N 22  
A1IHA C22  C N N 23  
A1IHA C23  C N N 24  
A1IHA C24  C N N 25  
A1IHA C25  C N N 26  
A1IHA C26  C N N 27  
A1IHA C27  C N N 28  
A1IHA C28  C N N 29  
A1IHA C29  C N N 30  
A1IHA C30  C N N 31  
A1IHA C31  C N N 32  
A1IHA C32  C N N 33  
A1IHA C33  C N N 34  
A1IHA C34  C N N 35  
A1IHA C35  C N N 36  
A1IHA C36  C N N 37  
A1IHA C37  C N N 38  
A1IHA C38  C N N 39  
A1IHA C39  C Y N 40  
A1IHA C40  C Y N 41  
A1IHA C41  C Y N 42  
A1IHA C42  C Y N 43  
A1IHA C43  C Y N 44  
A1IHA C44  C Y N 45  
A1IHA C45  C Y N 46  
A1IHA C46  C N N 47  
A1IHA C47  C Y N 48  
A1IHA C8   C Y N 49  
A1IHA C9   C Y N 50  
A1IHA N1   N Y N 51  
A1IHA N2   N N N 52  
A1IHA N3   N N N 53  
A1IHA N4   N Y N 54  
A1IHA O1   O N N 55  
A1IHA O2   O N N 56  
A1IHA O3   O N N 57  
A1IHA O4   O N N 58  
A1IHA O5   O N N 59  
A1IHA S    S N N 60  
A1IHA H3   H N N 61  
A1IHA H6   H N N 62  
A1IHA H5   H N N 63  
A1IHA H4   H N N 64  
A1IHA H8   H N N 65  
A1IHA H7   H N N 66  
A1IHA H1   H N N 67  
A1IHA H    H N N 68  
A1IHA H2   H N N 69  
A1IHA H10  H N N 70  
A1IHA H11  H N N 71  
A1IHA H12  H N N 72  
A1IHA H14  H N N 73  
A1IHA H13  H N N 74  
A1IHA H16  H N N 75  
A1IHA H15  H N N 76  
A1IHA H17  H N N 77  
A1IHA H18  H N N 78  
A1IHA H19  H N N 79  
A1IHA H20  H N N 80  
A1IHA H22  H N N 81  
A1IHA H21  H N N 82  
A1IHA H24  H N N 83  
A1IHA H23  H N N 84  
A1IHA H27  H N N 85  
A1IHA H26  H N N 86  
A1IHA H29  H N N 87  
A1IHA H28  H N N 88  
A1IHA H30  H N N 89  
A1IHA H31  H N N 90  
A1IHA H32  H N N 91  
A1IHA H33  H N N 92  
A1IHA H34  H N N 93  
A1IHA H35  H N N 94  
A1IHA H37  H N N 95  
A1IHA H38  H N N 96  
A1IHA H40  H N N 97  
A1IHA H39  H N N 98  
A1IHA H41  H N N 99  
A1IHA H43  H N N 100 
A1IHA H42  H N N 101 
A1IHA H44  H N N 102 
A1IHA H46  H N N 103 
A1IHA H45  H N N 104 
A1IHA H47  H N N 105 
A1IHA H48  H N N 106 
A1IHA H49  H N N 107 
A1IHA H51  H N N 108 
A1IHA H50  H N N 109 
A1IHA H53  H N N 110 
A1IHA H52  H N N 111 
A1IHA H54  H N N 112 
A1IHA H55  H N N 113 
A1IHA H56  H N N 114 
A1IHA H57  H N N 115 
A1IHA H58  H N N 116 
A1IHA H59  H N N 117 
A1IHA H60  H N N 118 
A1IHA H61  H N N 119 
A1IHA H63  H N N 120 
A1IHA H62  H N N 121 
A1IHA H64  H N N 122 
A1IHA H9   H N N 123 
A1IHA H25  H N N 124 
A1IHA H36  H N N 125 
ALA   N    N N N 126 
ALA   CA   C N S 127 
ALA   C    C N N 128 
ALA   O    O N N 129 
ALA   CB   C N N 130 
ALA   OXT  O N N 131 
ALA   H    H N N 132 
ALA   H2   H N N 133 
ALA   HA   H N N 134 
ALA   HB1  H N N 135 
ALA   HB2  H N N 136 
ALA   HB3  H N N 137 
ALA   HXT  H N N 138 
ARG   N    N N N 139 
ARG   CA   C N S 140 
ARG   C    C N N 141 
ARG   O    O N N 142 
ARG   CB   C N N 143 
ARG   CG   C N N 144 
ARG   CD   C N N 145 
ARG   NE   N N N 146 
ARG   CZ   C N N 147 
ARG   NH1  N N N 148 
ARG   NH2  N N N 149 
ARG   OXT  O N N 150 
ARG   H    H N N 151 
ARG   H2   H N N 152 
ARG   HA   H N N 153 
ARG   HB2  H N N 154 
ARG   HB3  H N N 155 
ARG   HG2  H N N 156 
ARG   HG3  H N N 157 
ARG   HD2  H N N 158 
ARG   HD3  H N N 159 
ARG   HE   H N N 160 
ARG   HH11 H N N 161 
ARG   HH12 H N N 162 
ARG   HH21 H N N 163 
ARG   HH22 H N N 164 
ARG   HXT  H N N 165 
ASN   N    N N N 166 
ASN   CA   C N S 167 
ASN   C    C N N 168 
ASN   O    O N N 169 
ASN   CB   C N N 170 
ASN   CG   C N N 171 
ASN   OD1  O N N 172 
ASN   ND2  N N N 173 
ASN   OXT  O N N 174 
ASN   H    H N N 175 
ASN   H2   H N N 176 
ASN   HA   H N N 177 
ASN   HB2  H N N 178 
ASN   HB3  H N N 179 
ASN   HD21 H N N 180 
ASN   HD22 H N N 181 
ASN   HXT  H N N 182 
ASP   N    N N N 183 
ASP   CA   C N S 184 
ASP   C    C N N 185 
ASP   O    O N N 186 
ASP   CB   C N N 187 
ASP   CG   C N N 188 
ASP   OD1  O N N 189 
ASP   OD2  O N N 190 
ASP   OXT  O N N 191 
ASP   H    H N N 192 
ASP   H2   H N N 193 
ASP   HA   H N N 194 
ASP   HB2  H N N 195 
ASP   HB3  H N N 196 
ASP   HD2  H N N 197 
ASP   HXT  H N N 198 
CYS   N    N N N 199 
CYS   CA   C N R 200 
CYS   C    C N N 201 
CYS   O    O N N 202 
CYS   CB   C N N 203 
CYS   SG   S N N 204 
CYS   OXT  O N N 205 
CYS   H    H N N 206 
CYS   H2   H N N 207 
CYS   HA   H N N 208 
CYS   HB2  H N N 209 
CYS   HB3  H N N 210 
CYS   HG   H N N 211 
CYS   HXT  H N N 212 
GLN   N    N N N 213 
GLN   CA   C N S 214 
GLN   C    C N N 215 
GLN   O    O N N 216 
GLN   CB   C N N 217 
GLN   CG   C N N 218 
GLN   CD   C N N 219 
GLN   OE1  O N N 220 
GLN   NE2  N N N 221 
GLN   OXT  O N N 222 
GLN   H    H N N 223 
GLN   H2   H N N 224 
GLN   HA   H N N 225 
GLN   HB2  H N N 226 
GLN   HB3  H N N 227 
GLN   HG2  H N N 228 
GLN   HG3  H N N 229 
GLN   HE21 H N N 230 
GLN   HE22 H N N 231 
GLN   HXT  H N N 232 
GLU   N    N N N 233 
GLU   CA   C N S 234 
GLU   C    C N N 235 
GLU   O    O N N 236 
GLU   CB   C N N 237 
GLU   CG   C N N 238 
GLU   CD   C N N 239 
GLU   OE1  O N N 240 
GLU   OE2  O N N 241 
GLU   OXT  O N N 242 
GLU   H    H N N 243 
GLU   H2   H N N 244 
GLU   HA   H N N 245 
GLU   HB2  H N N 246 
GLU   HB3  H N N 247 
GLU   HG2  H N N 248 
GLU   HG3  H N N 249 
GLU   HE2  H N N 250 
GLU   HXT  H N N 251 
GLY   N    N N N 252 
GLY   CA   C N N 253 
GLY   C    C N N 254 
GLY   O    O N N 255 
GLY   OXT  O N N 256 
GLY   H    H N N 257 
GLY   H2   H N N 258 
GLY   HA2  H N N 259 
GLY   HA3  H N N 260 
GLY   HXT  H N N 261 
GOL   C1   C N N 262 
GOL   O1   O N N 263 
GOL   C2   C N N 264 
GOL   O2   O N N 265 
GOL   C3   C N N 266 
GOL   O3   O N N 267 
GOL   H11  H N N 268 
GOL   H12  H N N 269 
GOL   HO1  H N N 270 
GOL   H2   H N N 271 
GOL   HO2  H N N 272 
GOL   H31  H N N 273 
GOL   H32  H N N 274 
GOL   HO3  H N N 275 
HIS   N    N N N 276 
HIS   CA   C N S 277 
HIS   C    C N N 278 
HIS   O    O N N 279 
HIS   CB   C N N 280 
HIS   CG   C Y N 281 
HIS   ND1  N Y N 282 
HIS   CD2  C Y N 283 
HIS   CE1  C Y N 284 
HIS   NE2  N Y N 285 
HIS   OXT  O N N 286 
HIS   H    H N N 287 
HIS   H2   H N N 288 
HIS   HA   H N N 289 
HIS   HB2  H N N 290 
HIS   HB3  H N N 291 
HIS   HD1  H N N 292 
HIS   HD2  H N N 293 
HIS   HE1  H N N 294 
HIS   HE2  H N N 295 
HIS   HXT  H N N 296 
HOH   O    O N N 297 
HOH   H1   H N N 298 
HOH   H2   H N N 299 
ILE   N    N N N 300 
ILE   CA   C N S 301 
ILE   C    C N N 302 
ILE   O    O N N 303 
ILE   CB   C N S 304 
ILE   CG1  C N N 305 
ILE   CG2  C N N 306 
ILE   CD1  C N N 307 
ILE   OXT  O N N 308 
ILE   H    H N N 309 
ILE   H2   H N N 310 
ILE   HA   H N N 311 
ILE   HB   H N N 312 
ILE   HG12 H N N 313 
ILE   HG13 H N N 314 
ILE   HG21 H N N 315 
ILE   HG22 H N N 316 
ILE   HG23 H N N 317 
ILE   HD11 H N N 318 
ILE   HD12 H N N 319 
ILE   HD13 H N N 320 
ILE   HXT  H N N 321 
IPA   C1   C N N 322 
IPA   C2   C N N 323 
IPA   C3   C N N 324 
IPA   O2   O N N 325 
IPA   H11  H N N 326 
IPA   H12  H N N 327 
IPA   H13  H N N 328 
IPA   H2   H N N 329 
IPA   H31  H N N 330 
IPA   H32  H N N 331 
IPA   H33  H N N 332 
IPA   HO2  H N N 333 
LEU   N    N N N 334 
LEU   CA   C N S 335 
LEU   C    C N N 336 
LEU   O    O N N 337 
LEU   CB   C N N 338 
LEU   CG   C N N 339 
LEU   CD1  C N N 340 
LEU   CD2  C N N 341 
LEU   OXT  O N N 342 
LEU   H    H N N 343 
LEU   H2   H N N 344 
LEU   HA   H N N 345 
LEU   HB2  H N N 346 
LEU   HB3  H N N 347 
LEU   HG   H N N 348 
LEU   HD11 H N N 349 
LEU   HD12 H N N 350 
LEU   HD13 H N N 351 
LEU   HD21 H N N 352 
LEU   HD22 H N N 353 
LEU   HD23 H N N 354 
LEU   HXT  H N N 355 
LYS   N    N N N 356 
LYS   CA   C N S 357 
LYS   C    C N N 358 
LYS   O    O N N 359 
LYS   CB   C N N 360 
LYS   CG   C N N 361 
LYS   CD   C N N 362 
LYS   CE   C N N 363 
LYS   NZ   N N N 364 
LYS   OXT  O N N 365 
LYS   H    H N N 366 
LYS   H2   H N N 367 
LYS   HA   H N N 368 
LYS   HB2  H N N 369 
LYS   HB3  H N N 370 
LYS   HG2  H N N 371 
LYS   HG3  H N N 372 
LYS   HD2  H N N 373 
LYS   HD3  H N N 374 
LYS   HE2  H N N 375 
LYS   HE3  H N N 376 
LYS   HZ1  H N N 377 
LYS   HZ2  H N N 378 
LYS   HZ3  H N N 379 
LYS   HXT  H N N 380 
MET   N    N N N 381 
MET   CA   C N S 382 
MET   C    C N N 383 
MET   O    O N N 384 
MET   CB   C N N 385 
MET   CG   C N N 386 
MET   SD   S N N 387 
MET   CE   C N N 388 
MET   OXT  O N N 389 
MET   H    H N N 390 
MET   H2   H N N 391 
MET   HA   H N N 392 
MET   HB2  H N N 393 
MET   HB3  H N N 394 
MET   HG2  H N N 395 
MET   HG3  H N N 396 
MET   HE1  H N N 397 
MET   HE2  H N N 398 
MET   HE3  H N N 399 
MET   HXT  H N N 400 
PHE   N    N N N 401 
PHE   CA   C N S 402 
PHE   C    C N N 403 
PHE   O    O N N 404 
PHE   CB   C N N 405 
PHE   CG   C Y N 406 
PHE   CD1  C Y N 407 
PHE   CD2  C Y N 408 
PHE   CE1  C Y N 409 
PHE   CE2  C Y N 410 
PHE   CZ   C Y N 411 
PHE   OXT  O N N 412 
PHE   H    H N N 413 
PHE   H2   H N N 414 
PHE   HA   H N N 415 
PHE   HB2  H N N 416 
PHE   HB3  H N N 417 
PHE   HD1  H N N 418 
PHE   HD2  H N N 419 
PHE   HE1  H N N 420 
PHE   HE2  H N N 421 
PHE   HZ   H N N 422 
PHE   HXT  H N N 423 
PRO   N    N N N 424 
PRO   CA   C N S 425 
PRO   C    C N N 426 
PRO   O    O N N 427 
PRO   CB   C N N 428 
PRO   CG   C N N 429 
PRO   CD   C N N 430 
PRO   OXT  O N N 431 
PRO   H    H N N 432 
PRO   HA   H N N 433 
PRO   HB2  H N N 434 
PRO   HB3  H N N 435 
PRO   HG2  H N N 436 
PRO   HG3  H N N 437 
PRO   HD2  H N N 438 
PRO   HD3  H N N 439 
PRO   HXT  H N N 440 
SER   N    N N N 441 
SER   CA   C N S 442 
SER   C    C N N 443 
SER   O    O N N 444 
SER   CB   C N N 445 
SER   OG   O N N 446 
SER   OXT  O N N 447 
SER   H    H N N 448 
SER   H2   H N N 449 
SER   HA   H N N 450 
SER   HB2  H N N 451 
SER   HB3  H N N 452 
SER   HG   H N N 453 
SER   HXT  H N N 454 
THR   N    N N N 455 
THR   CA   C N S 456 
THR   C    C N N 457 
THR   O    O N N 458 
THR   CB   C N R 459 
THR   OG1  O N N 460 
THR   CG2  C N N 461 
THR   OXT  O N N 462 
THR   H    H N N 463 
THR   H2   H N N 464 
THR   HA   H N N 465 
THR   HB   H N N 466 
THR   HG1  H N N 467 
THR   HG21 H N N 468 
THR   HG22 H N N 469 
THR   HG23 H N N 470 
THR   HXT  H N N 471 
TRP   N    N N N 472 
TRP   CA   C N S 473 
TRP   C    C N N 474 
TRP   O    O N N 475 
TRP   CB   C N N 476 
TRP   CG   C Y N 477 
TRP   CD1  C Y N 478 
TRP   CD2  C Y N 479 
TRP   NE1  N Y N 480 
TRP   CE2  C Y N 481 
TRP   CE3  C Y N 482 
TRP   CZ2  C Y N 483 
TRP   CZ3  C Y N 484 
TRP   CH2  C Y N 485 
TRP   OXT  O N N 486 
TRP   H    H N N 487 
TRP   H2   H N N 488 
TRP   HA   H N N 489 
TRP   HB2  H N N 490 
TRP   HB3  H N N 491 
TRP   HD1  H N N 492 
TRP   HE1  H N N 493 
TRP   HE3  H N N 494 
TRP   HZ2  H N N 495 
TRP   HZ3  H N N 496 
TRP   HH2  H N N 497 
TRP   HXT  H N N 498 
TYR   N    N N N 499 
TYR   CA   C N S 500 
TYR   C    C N N 501 
TYR   O    O N N 502 
TYR   CB   C N N 503 
TYR   CG   C Y N 504 
TYR   CD1  C Y N 505 
TYR   CD2  C Y N 506 
TYR   CE1  C Y N 507 
TYR   CE2  C Y N 508 
TYR   CZ   C Y N 509 
TYR   OH   O N N 510 
TYR   OXT  O N N 511 
TYR   H    H N N 512 
TYR   H2   H N N 513 
TYR   HA   H N N 514 
TYR   HB2  H N N 515 
TYR   HB3  H N N 516 
TYR   HD1  H N N 517 
TYR   HD2  H N N 518 
TYR   HE1  H N N 519 
TYR   HE2  H N N 520 
TYR   HH   H N N 521 
TYR   HXT  H N N 522 
VAL   N    N N N 523 
VAL   CA   C N S 524 
VAL   C    C N N 525 
VAL   O    O N N 526 
VAL   CB   C N N 527 
VAL   CG1  C N N 528 
VAL   CG2  C N N 529 
VAL   OXT  O N N 530 
VAL   H    H N N 531 
VAL   H2   H N N 532 
VAL   HA   H N N 533 
VAL   HB   H N N 534 
VAL   HG11 H N N 535 
VAL   HG12 H N N 536 
VAL   HG13 H N N 537 
VAL   HG21 H N N 538 
VAL   HG22 H N N 539 
VAL   HG23 H N N 540 
VAL   HXT  H N N 541 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1IHA C   C1   sing N N 1   
A1IHA C1  C2   doub Y N 2   
A1IHA C2  C3   sing Y N 3   
A1IHA C4  C3   sing N N 4   
A1IHA C3  C5   doub Y N 5   
A1IHA C5  S    sing N N 6   
A1IHA O   S    doub N N 7   
A1IHA O1  S    doub N N 8   
A1IHA S   N    sing N N 9   
A1IHA N   C6   sing N N 10  
A1IHA C6  C7   doub Y N 11  
A1IHA C7  C8   sing Y N 12  
A1IHA C8  C9   doub Y N 13  
A1IHA C9  C10  sing Y N 14  
A1IHA C11 C10  doub Y N 15  
A1IHA C6  C11  sing Y N 16  
A1IHA C10 N1   sing Y N 17  
A1IHA N1  C12  doub Y N 18  
A1IHA C12 C13  sing N N 19  
A1IHA C13 C14  sing N N 20  
A1IHA C14 C15  sing N N 21  
A1IHA C15 C16  sing N N 22  
A1IHA C16 C17  sing N N 23  
A1IHA C17 C18  sing N N 24  
A1IHA C18 C19  sing N N 25  
A1IHA C19 N2   sing N N 26  
A1IHA N2  C20  sing N N 27  
A1IHA O2  C20  doub N N 28  
A1IHA C20 C21  sing N N 29  
A1IHA C21 O3   sing N N 30  
A1IHA O3  C22  sing N N 31  
A1IHA C22 C23  sing N N 32  
A1IHA C23 O4   sing N N 33  
A1IHA O4  C24  sing N N 34  
A1IHA C24 C25  sing N N 35  
A1IHA C25 N3   sing N N 36  
A1IHA N3  C26  sing N N 37  
A1IHA C26 O5   doub N N 38  
A1IHA C27 C26  sing N N 39  
A1IHA C28 C27  sing N N 40  
A1IHA C28 C29  sing N N 41  
A1IHA C29 C30  sing N N 42  
A1IHA C30 C31  sing N N 43  
A1IHA C31 C32  sing N N 44  
A1IHA C32 C33  sing N N 45  
A1IHA C33 C34  sing N N 46  
A1IHA C35 C34  sing N N 47  
A1IHA C30 C35  sing N N 48  
A1IHA C34 C36  sing N N 49  
A1IHA C36 C28  sing N N 50  
A1IHA C32 C37  sing N N 51  
A1IHA C37 C28  sing N N 52  
A1IHA N4  C12  sing Y N 53  
A1IHA C9  N4   sing Y N 54  
A1IHA C38 N4   sing N N 55  
A1IHA C39 C38  sing N N 56  
A1IHA C39 C40  doub Y N 57  
A1IHA C40 C41  sing Y N 58  
A1IHA C41 C42  doub Y N 59  
A1IHA C42 C43  sing Y N 60  
A1IHA C43 C44  doub Y N 61  
A1IHA C44 C39  sing Y N 62  
A1IHA C45 C5   sing Y N 63  
A1IHA C46 C45  sing N N 64  
A1IHA C47 C45  doub Y N 65  
A1IHA C1  C47  sing Y N 66  
A1IHA C2  H3   sing N N 67  
A1IHA C4  H6   sing N N 68  
A1IHA C4  H5   sing N N 69  
A1IHA C4  H4   sing N N 70  
A1IHA C7  H8   sing N N 71  
A1IHA N   H7   sing N N 72  
A1IHA C   H1   sing N N 73  
A1IHA C   H    sing N N 74  
A1IHA C   H2   sing N N 75  
A1IHA C11 H10  sing N N 76  
A1IHA C13 H11  sing N N 77  
A1IHA C13 H12  sing N N 78  
A1IHA C14 H14  sing N N 79  
A1IHA C14 H13  sing N N 80  
A1IHA C15 H16  sing N N 81  
A1IHA C15 H15  sing N N 82  
A1IHA C16 H17  sing N N 83  
A1IHA C16 H18  sing N N 84  
A1IHA C17 H19  sing N N 85  
A1IHA C17 H20  sing N N 86  
A1IHA C18 H22  sing N N 87  
A1IHA C18 H21  sing N N 88  
A1IHA C19 H24  sing N N 89  
A1IHA C19 H23  sing N N 90  
A1IHA C21 H27  sing N N 91  
A1IHA C21 H26  sing N N 92  
A1IHA C22 H29  sing N N 93  
A1IHA C22 H28  sing N N 94  
A1IHA C23 H30  sing N N 95  
A1IHA C23 H31  sing N N 96  
A1IHA C24 H32  sing N N 97  
A1IHA C24 H33  sing N N 98  
A1IHA C25 H34  sing N N 99  
A1IHA C25 H35  sing N N 100 
A1IHA C27 H37  sing N N 101 
A1IHA C27 H38  sing N N 102 
A1IHA C29 H40  sing N N 103 
A1IHA C29 H39  sing N N 104 
A1IHA C30 H41  sing N N 105 
A1IHA C31 H43  sing N N 106 
A1IHA C31 H42  sing N N 107 
A1IHA C32 H44  sing N N 108 
A1IHA C33 H46  sing N N 109 
A1IHA C33 H45  sing N N 110 
A1IHA C34 H47  sing N N 111 
A1IHA C35 H48  sing N N 112 
A1IHA C35 H49  sing N N 113 
A1IHA C36 H51  sing N N 114 
A1IHA C36 H50  sing N N 115 
A1IHA C37 H53  sing N N 116 
A1IHA C37 H52  sing N N 117 
A1IHA C38 H54  sing N N 118 
A1IHA C38 H55  sing N N 119 
A1IHA C40 H56  sing N N 120 
A1IHA C41 H57  sing N N 121 
A1IHA C42 H58  sing N N 122 
A1IHA C43 H59  sing N N 123 
A1IHA C44 H60  sing N N 124 
A1IHA C46 H61  sing N N 125 
A1IHA C46 H63  sing N N 126 
A1IHA C46 H62  sing N N 127 
A1IHA C47 H64  sing N N 128 
A1IHA C8  H9   sing N N 129 
A1IHA N2  H25  sing N N 130 
A1IHA N3  H36  sing N N 131 
ALA   N   CA   sing N N 132 
ALA   N   H    sing N N 133 
ALA   N   H2   sing N N 134 
ALA   CA  C    sing N N 135 
ALA   CA  CB   sing N N 136 
ALA   CA  HA   sing N N 137 
ALA   C   O    doub N N 138 
ALA   C   OXT  sing N N 139 
ALA   CB  HB1  sing N N 140 
ALA   CB  HB2  sing N N 141 
ALA   CB  HB3  sing N N 142 
ALA   OXT HXT  sing N N 143 
ARG   N   CA   sing N N 144 
ARG   N   H    sing N N 145 
ARG   N   H2   sing N N 146 
ARG   CA  C    sing N N 147 
ARG   CA  CB   sing N N 148 
ARG   CA  HA   sing N N 149 
ARG   C   O    doub N N 150 
ARG   C   OXT  sing N N 151 
ARG   CB  CG   sing N N 152 
ARG   CB  HB2  sing N N 153 
ARG   CB  HB3  sing N N 154 
ARG   CG  CD   sing N N 155 
ARG   CG  HG2  sing N N 156 
ARG   CG  HG3  sing N N 157 
ARG   CD  NE   sing N N 158 
ARG   CD  HD2  sing N N 159 
ARG   CD  HD3  sing N N 160 
ARG   NE  CZ   sing N N 161 
ARG   NE  HE   sing N N 162 
ARG   CZ  NH1  sing N N 163 
ARG   CZ  NH2  doub N N 164 
ARG   NH1 HH11 sing N N 165 
ARG   NH1 HH12 sing N N 166 
ARG   NH2 HH21 sing N N 167 
ARG   NH2 HH22 sing N N 168 
ARG   OXT HXT  sing N N 169 
ASN   N   CA   sing N N 170 
ASN   N   H    sing N N 171 
ASN   N   H2   sing N N 172 
ASN   CA  C    sing N N 173 
ASN   CA  CB   sing N N 174 
ASN   CA  HA   sing N N 175 
ASN   C   O    doub N N 176 
ASN   C   OXT  sing N N 177 
ASN   CB  CG   sing N N 178 
ASN   CB  HB2  sing N N 179 
ASN   CB  HB3  sing N N 180 
ASN   CG  OD1  doub N N 181 
ASN   CG  ND2  sing N N 182 
ASN   ND2 HD21 sing N N 183 
ASN   ND2 HD22 sing N N 184 
ASN   OXT HXT  sing N N 185 
ASP   N   CA   sing N N 186 
ASP   N   H    sing N N 187 
ASP   N   H2   sing N N 188 
ASP   CA  C    sing N N 189 
ASP   CA  CB   sing N N 190 
ASP   CA  HA   sing N N 191 
ASP   C   O    doub N N 192 
ASP   C   OXT  sing N N 193 
ASP   CB  CG   sing N N 194 
ASP   CB  HB2  sing N N 195 
ASP   CB  HB3  sing N N 196 
ASP   CG  OD1  doub N N 197 
ASP   CG  OD2  sing N N 198 
ASP   OD2 HD2  sing N N 199 
ASP   OXT HXT  sing N N 200 
CYS   N   CA   sing N N 201 
CYS   N   H    sing N N 202 
CYS   N   H2   sing N N 203 
CYS   CA  C    sing N N 204 
CYS   CA  CB   sing N N 205 
CYS   CA  HA   sing N N 206 
CYS   C   O    doub N N 207 
CYS   C   OXT  sing N N 208 
CYS   CB  SG   sing N N 209 
CYS   CB  HB2  sing N N 210 
CYS   CB  HB3  sing N N 211 
CYS   SG  HG   sing N N 212 
CYS   OXT HXT  sing N N 213 
GLN   N   CA   sing N N 214 
GLN   N   H    sing N N 215 
GLN   N   H2   sing N N 216 
GLN   CA  C    sing N N 217 
GLN   CA  CB   sing N N 218 
GLN   CA  HA   sing N N 219 
GLN   C   O    doub N N 220 
GLN   C   OXT  sing N N 221 
GLN   CB  CG   sing N N 222 
GLN   CB  HB2  sing N N 223 
GLN   CB  HB3  sing N N 224 
GLN   CG  CD   sing N N 225 
GLN   CG  HG2  sing N N 226 
GLN   CG  HG3  sing N N 227 
GLN   CD  OE1  doub N N 228 
GLN   CD  NE2  sing N N 229 
GLN   NE2 HE21 sing N N 230 
GLN   NE2 HE22 sing N N 231 
GLN   OXT HXT  sing N N 232 
GLU   N   CA   sing N N 233 
GLU   N   H    sing N N 234 
GLU   N   H2   sing N N 235 
GLU   CA  C    sing N N 236 
GLU   CA  CB   sing N N 237 
GLU   CA  HA   sing N N 238 
GLU   C   O    doub N N 239 
GLU   C   OXT  sing N N 240 
GLU   CB  CG   sing N N 241 
GLU   CB  HB2  sing N N 242 
GLU   CB  HB3  sing N N 243 
GLU   CG  CD   sing N N 244 
GLU   CG  HG2  sing N N 245 
GLU   CG  HG3  sing N N 246 
GLU   CD  OE1  doub N N 247 
GLU   CD  OE2  sing N N 248 
GLU   OE2 HE2  sing N N 249 
GLU   OXT HXT  sing N N 250 
GLY   N   CA   sing N N 251 
GLY   N   H    sing N N 252 
GLY   N   H2   sing N N 253 
GLY   CA  C    sing N N 254 
GLY   CA  HA2  sing N N 255 
GLY   CA  HA3  sing N N 256 
GLY   C   O    doub N N 257 
GLY   C   OXT  sing N N 258 
GLY   OXT HXT  sing N N 259 
GOL   C1  O1   sing N N 260 
GOL   C1  C2   sing N N 261 
GOL   C1  H11  sing N N 262 
GOL   C1  H12  sing N N 263 
GOL   O1  HO1  sing N N 264 
GOL   C2  O2   sing N N 265 
GOL   C2  C3   sing N N 266 
GOL   C2  H2   sing N N 267 
GOL   O2  HO2  sing N N 268 
GOL   C3  O3   sing N N 269 
GOL   C3  H31  sing N N 270 
GOL   C3  H32  sing N N 271 
GOL   O3  HO3  sing N N 272 
HIS   N   CA   sing N N 273 
HIS   N   H    sing N N 274 
HIS   N   H2   sing N N 275 
HIS   CA  C    sing N N 276 
HIS   CA  CB   sing N N 277 
HIS   CA  HA   sing N N 278 
HIS   C   O    doub N N 279 
HIS   C   OXT  sing N N 280 
HIS   CB  CG   sing N N 281 
HIS   CB  HB2  sing N N 282 
HIS   CB  HB3  sing N N 283 
HIS   CG  ND1  sing Y N 284 
HIS   CG  CD2  doub Y N 285 
HIS   ND1 CE1  doub Y N 286 
HIS   ND1 HD1  sing N N 287 
HIS   CD2 NE2  sing Y N 288 
HIS   CD2 HD2  sing N N 289 
HIS   CE1 NE2  sing Y N 290 
HIS   CE1 HE1  sing N N 291 
HIS   NE2 HE2  sing N N 292 
HIS   OXT HXT  sing N N 293 
HOH   O   H1   sing N N 294 
HOH   O   H2   sing N N 295 
ILE   N   CA   sing N N 296 
ILE   N   H    sing N N 297 
ILE   N   H2   sing N N 298 
ILE   CA  C    sing N N 299 
ILE   CA  CB   sing N N 300 
ILE   CA  HA   sing N N 301 
ILE   C   O    doub N N 302 
ILE   C   OXT  sing N N 303 
ILE   CB  CG1  sing N N 304 
ILE   CB  CG2  sing N N 305 
ILE   CB  HB   sing N N 306 
ILE   CG1 CD1  sing N N 307 
ILE   CG1 HG12 sing N N 308 
ILE   CG1 HG13 sing N N 309 
ILE   CG2 HG21 sing N N 310 
ILE   CG2 HG22 sing N N 311 
ILE   CG2 HG23 sing N N 312 
ILE   CD1 HD11 sing N N 313 
ILE   CD1 HD12 sing N N 314 
ILE   CD1 HD13 sing N N 315 
ILE   OXT HXT  sing N N 316 
IPA   C1  C2   sing N N 317 
IPA   C1  H11  sing N N 318 
IPA   C1  H12  sing N N 319 
IPA   C1  H13  sing N N 320 
IPA   C2  C3   sing N N 321 
IPA   C2  O2   sing N N 322 
IPA   C2  H2   sing N N 323 
IPA   C3  H31  sing N N 324 
IPA   C3  H32  sing N N 325 
IPA   C3  H33  sing N N 326 
IPA   O2  HO2  sing N N 327 
LEU   N   CA   sing N N 328 
LEU   N   H    sing N N 329 
LEU   N   H2   sing N N 330 
LEU   CA  C    sing N N 331 
LEU   CA  CB   sing N N 332 
LEU   CA  HA   sing N N 333 
LEU   C   O    doub N N 334 
LEU   C   OXT  sing N N 335 
LEU   CB  CG   sing N N 336 
LEU   CB  HB2  sing N N 337 
LEU   CB  HB3  sing N N 338 
LEU   CG  CD1  sing N N 339 
LEU   CG  CD2  sing N N 340 
LEU   CG  HG   sing N N 341 
LEU   CD1 HD11 sing N N 342 
LEU   CD1 HD12 sing N N 343 
LEU   CD1 HD13 sing N N 344 
LEU   CD2 HD21 sing N N 345 
LEU   CD2 HD22 sing N N 346 
LEU   CD2 HD23 sing N N 347 
LEU   OXT HXT  sing N N 348 
LYS   N   CA   sing N N 349 
LYS   N   H    sing N N 350 
LYS   N   H2   sing N N 351 
LYS   CA  C    sing N N 352 
LYS   CA  CB   sing N N 353 
LYS   CA  HA   sing N N 354 
LYS   C   O    doub N N 355 
LYS   C   OXT  sing N N 356 
LYS   CB  CG   sing N N 357 
LYS   CB  HB2  sing N N 358 
LYS   CB  HB3  sing N N 359 
LYS   CG  CD   sing N N 360 
LYS   CG  HG2  sing N N 361 
LYS   CG  HG3  sing N N 362 
LYS   CD  CE   sing N N 363 
LYS   CD  HD2  sing N N 364 
LYS   CD  HD3  sing N N 365 
LYS   CE  NZ   sing N N 366 
LYS   CE  HE2  sing N N 367 
LYS   CE  HE3  sing N N 368 
LYS   NZ  HZ1  sing N N 369 
LYS   NZ  HZ2  sing N N 370 
LYS   NZ  HZ3  sing N N 371 
LYS   OXT HXT  sing N N 372 
MET   N   CA   sing N N 373 
MET   N   H    sing N N 374 
MET   N   H2   sing N N 375 
MET   CA  C    sing N N 376 
MET   CA  CB   sing N N 377 
MET   CA  HA   sing N N 378 
MET   C   O    doub N N 379 
MET   C   OXT  sing N N 380 
MET   CB  CG   sing N N 381 
MET   CB  HB2  sing N N 382 
MET   CB  HB3  sing N N 383 
MET   CG  SD   sing N N 384 
MET   CG  HG2  sing N N 385 
MET   CG  HG3  sing N N 386 
MET   SD  CE   sing N N 387 
MET   CE  HE1  sing N N 388 
MET   CE  HE2  sing N N 389 
MET   CE  HE3  sing N N 390 
MET   OXT HXT  sing N N 391 
PHE   N   CA   sing N N 392 
PHE   N   H    sing N N 393 
PHE   N   H2   sing N N 394 
PHE   CA  C    sing N N 395 
PHE   CA  CB   sing N N 396 
PHE   CA  HA   sing N N 397 
PHE   C   O    doub N N 398 
PHE   C   OXT  sing N N 399 
PHE   CB  CG   sing N N 400 
PHE   CB  HB2  sing N N 401 
PHE   CB  HB3  sing N N 402 
PHE   CG  CD1  doub Y N 403 
PHE   CG  CD2  sing Y N 404 
PHE   CD1 CE1  sing Y N 405 
PHE   CD1 HD1  sing N N 406 
PHE   CD2 CE2  doub Y N 407 
PHE   CD2 HD2  sing N N 408 
PHE   CE1 CZ   doub Y N 409 
PHE   CE1 HE1  sing N N 410 
PHE   CE2 CZ   sing Y N 411 
PHE   CE2 HE2  sing N N 412 
PHE   CZ  HZ   sing N N 413 
PHE   OXT HXT  sing N N 414 
PRO   N   CA   sing N N 415 
PRO   N   CD   sing N N 416 
PRO   N   H    sing N N 417 
PRO   CA  C    sing N N 418 
PRO   CA  CB   sing N N 419 
PRO   CA  HA   sing N N 420 
PRO   C   O    doub N N 421 
PRO   C   OXT  sing N N 422 
PRO   CB  CG   sing N N 423 
PRO   CB  HB2  sing N N 424 
PRO   CB  HB3  sing N N 425 
PRO   CG  CD   sing N N 426 
PRO   CG  HG2  sing N N 427 
PRO   CG  HG3  sing N N 428 
PRO   CD  HD2  sing N N 429 
PRO   CD  HD3  sing N N 430 
PRO   OXT HXT  sing N N 431 
SER   N   CA   sing N N 432 
SER   N   H    sing N N 433 
SER   N   H2   sing N N 434 
SER   CA  C    sing N N 435 
SER   CA  CB   sing N N 436 
SER   CA  HA   sing N N 437 
SER   C   O    doub N N 438 
SER   C   OXT  sing N N 439 
SER   CB  OG   sing N N 440 
SER   CB  HB2  sing N N 441 
SER   CB  HB3  sing N N 442 
SER   OG  HG   sing N N 443 
SER   OXT HXT  sing N N 444 
THR   N   CA   sing N N 445 
THR   N   H    sing N N 446 
THR   N   H2   sing N N 447 
THR   CA  C    sing N N 448 
THR   CA  CB   sing N N 449 
THR   CA  HA   sing N N 450 
THR   C   O    doub N N 451 
THR   C   OXT  sing N N 452 
THR   CB  OG1  sing N N 453 
THR   CB  CG2  sing N N 454 
THR   CB  HB   sing N N 455 
THR   OG1 HG1  sing N N 456 
THR   CG2 HG21 sing N N 457 
THR   CG2 HG22 sing N N 458 
THR   CG2 HG23 sing N N 459 
THR   OXT HXT  sing N N 460 
TRP   N   CA   sing N N 461 
TRP   N   H    sing N N 462 
TRP   N   H2   sing N N 463 
TRP   CA  C    sing N N 464 
TRP   CA  CB   sing N N 465 
TRP   CA  HA   sing N N 466 
TRP   C   O    doub N N 467 
TRP   C   OXT  sing N N 468 
TRP   CB  CG   sing N N 469 
TRP   CB  HB2  sing N N 470 
TRP   CB  HB3  sing N N 471 
TRP   CG  CD1  doub Y N 472 
TRP   CG  CD2  sing Y N 473 
TRP   CD1 NE1  sing Y N 474 
TRP   CD1 HD1  sing N N 475 
TRP   CD2 CE2  doub Y N 476 
TRP   CD2 CE3  sing Y N 477 
TRP   NE1 CE2  sing Y N 478 
TRP   NE1 HE1  sing N N 479 
TRP   CE2 CZ2  sing Y N 480 
TRP   CE3 CZ3  doub Y N 481 
TRP   CE3 HE3  sing N N 482 
TRP   CZ2 CH2  doub Y N 483 
TRP   CZ2 HZ2  sing N N 484 
TRP   CZ3 CH2  sing Y N 485 
TRP   CZ3 HZ3  sing N N 486 
TRP   CH2 HH2  sing N N 487 
TRP   OXT HXT  sing N N 488 
TYR   N   CA   sing N N 489 
TYR   N   H    sing N N 490 
TYR   N   H2   sing N N 491 
TYR   CA  C    sing N N 492 
TYR   CA  CB   sing N N 493 
TYR   CA  HA   sing N N 494 
TYR   C   O    doub N N 495 
TYR   C   OXT  sing N N 496 
TYR   CB  CG   sing N N 497 
TYR   CB  HB2  sing N N 498 
TYR   CB  HB3  sing N N 499 
TYR   CG  CD1  doub Y N 500 
TYR   CG  CD2  sing Y N 501 
TYR   CD1 CE1  sing Y N 502 
TYR   CD1 HD1  sing N N 503 
TYR   CD2 CE2  doub Y N 504 
TYR   CD2 HD2  sing N N 505 
TYR   CE1 CZ   doub Y N 506 
TYR   CE1 HE1  sing N N 507 
TYR   CE2 CZ   sing Y N 508 
TYR   CE2 HE2  sing N N 509 
TYR   CZ  OH   sing N N 510 
TYR   OH  HH   sing N N 511 
TYR   OXT HXT  sing N N 512 
VAL   N   CA   sing N N 513 
VAL   N   H    sing N N 514 
VAL   N   H2   sing N N 515 
VAL   CA  C    sing N N 516 
VAL   CA  CB   sing N N 517 
VAL   CA  HA   sing N N 518 
VAL   C   O    doub N N 519 
VAL   C   OXT  sing N N 520 
VAL   CB  CG1  sing N N 521 
VAL   CB  CG2  sing N N 522 
VAL   CB  HB   sing N N 523 
VAL   CG1 HG11 sing N N 524 
VAL   CG1 HG12 sing N N 525 
VAL   CG1 HG13 sing N N 526 
VAL   CG2 HG21 sing N N 527 
VAL   CG2 HG22 sing N N 528 
VAL   CG2 HG23 sing N N 529 
VAL   OXT HXT  sing N N 530 
# 
_pdbx_audit_support.funding_organization   'Agence Nationale de la Recherche (ANR)' 
_pdbx_audit_support.country                France 
_pdbx_audit_support.grant_number           ANR-17-CE18-035 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1ILG 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FZG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010984 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010984 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011547 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY   A 1 24  ? -6.00253  43.82725 9.57109   1.000 64.69913 ? 142 GLY   A N   1 
ATOM   2    C CA  . GLY   A 1 24  ? -5.91728  43.41293 10.96598  1.000 61.67723 ? 142 GLY   A CA  1 
ATOM   3    C C   . GLY   A 1 24  ? -6.30294  44.53863 11.91450  1.000 58.30601 ? 142 GLY   A C   1 
ATOM   4    O O   . GLY   A 1 24  ? -6.01805  44.50164 13.11337  1.000 60.43593 ? 142 GLY   A O   1 
ATOM   5    N N   . LEU   A 1 25  ? -6.96648  45.53928 11.34876  1.000 51.08903 ? 143 LEU   A N   1 
ATOM   6    C CA  . LEU   A 1 25  ? -7.39312  46.75906 12.01347  1.000 46.66880 ? 143 LEU   A CA  1 
ATOM   7    C C   . LEU   A 1 25  ? -8.86565  46.61463 12.42532  1.000 47.37922 ? 143 LEU   A C   1 
ATOM   8    O O   . LEU   A 1 25  ? -9.56215  45.71238 11.95478  1.000 54.35220 ? 143 LEU   A O   1 
ATOM   9    C CB  . LEU   A 1 25  ? -7.20215  47.91968 11.02827  1.000 50.07396 ? 143 LEU   A CB  1 
ATOM   10   C CG  . LEU   A 1 25  ? -5.75732  48.26971 10.61409  1.000 43.03843 ? 143 LEU   A CG  1 
ATOM   11   C CD1 . LEU   A 1 25  ? -5.71755  48.81035 9.19544   1.000 46.09725 ? 143 LEU   A CD1 1 
ATOM   12   C CD2 . LEU   A 1 25  ? -5.20868  49.29628 11.54749  1.000 46.29746 ? 143 LEU   A CD2 1 
ATOM   13   N N   . THR   A 1 26  ? -9.34661  47.50490 13.30574  1.000 48.97271 ? 144 THR   A N   1 
ATOM   14   C CA  . THR   A 1 26  ? -10.78723 47.64385 13.55357  1.000 49.99991 ? 144 THR   A CA  1 
ATOM   15   C C   . THR   A 1 26  ? -11.46955 48.21389 12.31548  1.000 53.12468 ? 144 THR   A C   1 
ATOM   16   O O   . THR   A 1 26  ? -10.79119 48.64903 11.38293  1.000 44.41096 ? 144 THR   A O   1 
ATOM   17   C CB  . THR   A 1 26  ? -11.00011 48.50848 14.80969  1.000 47.77771 ? 144 THR   A CB  1 
ATOM   18   O OG1 . THR   A 1 26  ? -10.81353 49.88272 14.44474  1.000 46.99295 ? 144 THR   A OG1 1 
ATOM   19   C CG2 . THR   A 1 26  ? -9.98935  48.14662 15.91438  1.000 49.70051 ? 144 THR   A CG2 1 
ATOM   20   N N   . GLU   A 1 27  ? -12.81873 48.21693 12.23502  1.000 53.23340 ? 145 GLU   A N   1 
ATOM   21   C CA  . GLU   A 1 27  ? -13.37137 48.97463 11.08931  1.000 56.11801 ? 145 GLU   A CA  1 
ATOM   22   C C   . GLU   A 1 27  ? -13.19222 50.43912 11.30051  1.000 50.29622 ? 145 GLU   A C   1 
ATOM   23   O O   . GLU   A 1 27  ? -13.11806 51.18030 10.33017  1.000 51.68729 ? 145 GLU   A O   1 
ATOM   24   C CB  . GLU   A 1 27  ? -14.86525 48.76809 10.85950  1.000 63.35799 ? 145 GLU   A CB  1 
ATOM   25   C CG  . GLU   A 1 27  ? -15.29309 47.38947 10.49732  1.000 63.73380 ? 145 GLU   A CG  1 
ATOM   26   C CD  . GLU   A 1 27  ? -14.77460 46.89254 9.17507   1.000 72.73970 ? 145 GLU   A CD  1 
ATOM   27   O OE1 . GLU   A 1 27  ? -14.55748 47.69968 8.26517   1.000 76.70165 ? 145 GLU   A OE1 1 
ATOM   28   O OE2 . GLU   A 1 27  ? -14.65544 45.62770 9.11982   1.000 78.89327 ? 145 GLU   A OE2 1 
ATOM   29   N N   . GLU   A 1 28  ? -13.23998 50.88376 12.56406  1.000 42.00976 ? 146 GLU   A N   1 
ATOM   30   C CA  . GLU   A 1 28  ? -13.02039 52.30086 12.78694  1.000 50.49685 ? 146 GLU   A CA  1 
ATOM   31   C C   . GLU   A 1 28  ? -11.70114 52.71018 12.16789  1.000 43.30393 ? 146 GLU   A C   1 
ATOM   32   O O   . GLU   A 1 28  ? -11.62557 53.74131 11.50565  1.000 42.71069 ? 146 GLU   A O   1 
ATOM   33   C CB  . GLU   A 1 28  ? -13.06715 52.60584 14.27990  1.000 48.67021 ? 146 GLU   A CB  1 
ATOM   34   N N   . GLN   A 1 29  ? -10.68530 51.85186 12.28382  1.000 41.47461 ? 147 GLN   A N   1 
ATOM   35   C CA  . GLN   A 1 29  ? -9.38187  52.14992 11.71086  1.000 39.30250 ? 147 GLN   A CA  1 
ATOM   36   C C   . GLN   A 1 29  ? -9.39697  51.98938 10.19662  1.000 42.53269 ? 147 GLN   A C   1 
ATOM   37   O O   . GLN   A 1 29  ? -8.81606  52.81384 9.47663   1.000 33.94310 ? 147 GLN   A O   1 
ATOM   38   C CB  . GLN   A 1 29  ? -8.33078  51.25285 12.36289  1.000 38.53423 ? 147 GLN   A CB  1 
ATOM   39   C CG  . GLN   A 1 29  ? -8.17146  51.56524 13.85361  1.000 40.07402 ? 147 GLN   A CG  1 
ATOM   40   C CD  . GLN   A 1 29  ? -7.19701  50.64623 14.58715  1.000 40.59735 ? 147 GLN   A CD  1 
ATOM   41   O OE1 . GLN   A 1 29  ? -7.01267  49.48455 14.23083  1.000 35.30652 ? 147 GLN   A OE1 1 
ATOM   42   N NE2 . GLN   A 1 29  ? -6.56372  51.18136 15.61970  1.000 45.44906 ? 147 GLN   A NE2 1 
ATOM   43   N N   . ARG   A 1 30  ? -10.06871 50.94400 9.69341   1.000 35.22238 ? 148 ARG   A N   1 
ATOM   44   C CA  . ARG   A 1 30  ? -10.16064 50.74968 8.24893   1.000 40.99135 ? 148 ARG   A CA  1 
ATOM   45   C C   . ARG   A 1 30  ? -10.94980 51.87284 7.59234   1.000 40.10765 ? 148 ARG   A C   1 
ATOM   46   O O   . ARG   A 1 30  ? -10.61486 52.31456 6.48290   1.000 34.09141 ? 148 ARG   A O   1 
ATOM   47   C CB  . ARG   A 1 30  ? -10.80118 49.39723 7.92881   1.000 44.67627 ? 148 ARG   A CB  1 
ATOM   48   C CG  . ARG   A 1 30  ? -9.83578  48.23475 7.96876   1.000 48.40844 ? 148 ARG   A CG  1 
ATOM   49   C CD  . ARG   A 1 30  ? -10.42289 46.97536 7.34360   1.000 52.40339 ? 148 ARG   A CD  1 
ATOM   50   N NE  . ARG   A 1 30  ? -11.47801 46.40429 8.17022   1.000 66.28612 ? 148 ARG   A NE  1 
ATOM   51   C CZ  . ARG   A 1 30  ? -11.26954 45.51531 9.13794   1.000 66.39256 ? 148 ARG   A CZ  1 
ATOM   52   N NH1 . ARG   A 1 30  ? -10.03515 45.09579 9.41005   1.000 67.06455 ? 148 ARG   A NH1 1 
ATOM   53   N NH2 . ARG   A 1 30  ? -12.29604 45.05085 9.83738   1.000 60.98796 ? 148 ARG   A NH2 1 
ATOM   54   N N   . MET   A 1 31  ? -12.00276 52.34428 8.25874   1.000 34.88631 ? 149 MET   A N   1 
ATOM   55   C CA  . MET   A 1 31  ? -12.80994 53.42222 7.70307   1.000 38.17089 ? 149 MET   A CA  1 
ATOM   56   C C   . MET   A 1 31  ? -12.06042 54.74496 7.73369   1.000 36.36774 ? 149 MET   A C   1 
ATOM   57   O O   . MET   A 1 31  ? -12.26517 55.60315 6.86892   1.000 31.26814 ? 149 MET   A O   1 
ATOM   58   C CB  . MET   A 1 31  ? -14.12102 53.53128 8.48082   1.000 39.43714 ? 149 MET   A CB  1 
ATOM   59   C CG  . MET   A 1 31  ? -15.14935 52.47646 8.07594   1.000 60.66661 ? 149 MET   A CG  1 
ATOM   60   S SD  . MET   A 1 31  ? -15.23067 52.21948 6.27735   1.000 75.51544 ? 149 MET   A SD  1 
ATOM   61   C CE  . MET   A 1 31  ? -14.30549 50.69106 6.04925   1.000 50.90769 ? 149 MET   A CE  1 
ATOM   62   N N   . MET   A 1 32  ? -11.21427 54.92959 8.73964   1.000 29.80483 ? 150 MET   A N   1 
ATOM   63   C CA  . MET   A 1 32  ? -10.40124 56.12906 8.83417   1.000 33.50474 ? 150 MET   A CA  1 
ATOM   64   C C   . MET   A 1 32  ? -9.37480  56.17406 7.69953   1.000 28.47929 ? 150 MET   A C   1 
ATOM   65   O O   . MET   A 1 32  ? -9.22153  57.20235 7.02958   1.000 26.47050 ? 150 MET   A O   1 
ATOM   66   C CB  . MET   A 1 32  ? -9.74415  56.14961 10.21985  1.000 33.36085 ? 150 MET   A CB  1 
ATOM   67   C CG  . MET   A 1 32  ? -8.65032  57.14398 10.43855  1.000 32.27530 ? 150 MET   A CG  1 
ATOM   68   S SD  . MET   A 1 32  ? -8.04623  57.00738 12.15516  1.000 42.96623 ? 150 MET   A SD  1 
ATOM   69   C CE  . MET   A 1 32  ? -9.36673  57.80568 13.03797  1.000 37.33781 ? 150 MET   A CE  1 
ATOM   70   N N   . ILE   A 1 33  ? -8.71184  55.04966 7.42697   1.000 27.01957 ? 151 ILE   A N   1 
ATOM   71   C CA  . ILE   A 1 33  ? -7.77258  55.00866 6.30871   1.000 27.83930 ? 151 ILE   A CA  1 
ATOM   72   C C   . ILE   A 1 33  ? -8.50009  55.21884 4.98945   1.000 28.43420 ? 151 ILE   A C   1 
ATOM   73   O O   . ILE   A 1 33  ? -8.03874  55.97825 4.12521   1.000 28.13894 ? 151 ILE   A O   1 
ATOM   74   C CB  . ILE   A 1 33  ? -6.98286  53.69206 6.31882   1.000 23.66955 ? 151 ILE   A CB  1 
ATOM   75   C CG1 . ILE   A 1 33  ? -6.05419  53.64344 7.53835   1.000 26.39742 ? 151 ILE   A CG1 1 
ATOM   76   C CG2 . ILE   A 1 33  ? -6.17999  53.52064 4.98966   1.000 27.78281 ? 151 ILE   A CG2 1 
ATOM   77   C CD1 . ILE   A 1 33  ? -5.48662  52.26001 7.78891   1.000 29.69178 ? 151 ILE   A CD1 1 
ATOM   78   N N   . ARG   A 1 34  ? -9.65172  54.55308 4.81058   1.000 27.75917 ? 152 ARG   A N   1 
ATOM   79   C CA  . ARG   A 1 34  ? -10.41886 54.72881 3.58080   1.000 32.51116 ? 152 ARG   A CA  1 
ATOM   80   C C   . ARG   A 1 34  ? -10.79572 56.18815 3.37728   1.000 28.08218 ? 152 ARG   A C   1 
ATOM   81   O O   . ARG   A 1 34  ? -10.69933 56.70365 2.26360   1.000 28.23433 ? 152 ARG   A O   1 
ATOM   82   C CB  . ARG   A 1 34  ? -11.66833 53.84210 3.59186   1.000 28.31053 ? 152 ARG   A CB  1 
ATOM   83   N N   . GLU   A 1 35  ? -11.20970 56.88159 4.44397   1.000 27.77275 ? 153 GLU   A N   1 
ATOM   84   C CA  . GLU   A 1 35  ? -11.57795 58.28633 4.28939   1.000 28.59709 ? 153 GLU   A CA  1 
ATOM   85   C C   . GLU   A 1 35  ? -10.38363 59.14677 3.89026   1.000 28.64898 ? 153 GLU   A C   1 
ATOM   86   O O   . GLU   A 1 35  ? -10.50643 60.02983 3.03186   1.000 26.46427 ? 153 GLU   A O   1 
ATOM   87   C CB  . GLU   A 1 35  ? -12.19229 58.84523 5.56541   1.000 29.46851 ? 153 GLU   A CB  1 
ATOM   88   C CG  . GLU   A 1 35  ? -12.88580 60.13684 5.22487   1.000 38.77017 ? 153 GLU   A CG  1 
ATOM   89   C CD  . GLU   A 1 35  ? -13.50017 60.85264 6.38209   1.000 42.43124 ? 153 GLU   A CD  1 
ATOM   90   O OE1 . GLU   A 1 35  ? -13.30331 60.44016 7.54617   1.000 44.58803 ? 153 GLU   A OE1 1 
ATOM   91   O OE2 . GLU   A 1 35  ? -14.20256 61.84231 6.10302   1.000 40.82763 ? 153 GLU   A OE2 1 
ATOM   92   N N   . LEU   A 1 36  ? -9.23090  58.92086 4.52556   1.000 27.50410 ? 154 LEU   A N   1 
ATOM   93   C CA  . LEU   A 1 36  ? -8.01373  59.65827 4.18914   1.000 23.89549 ? 154 LEU   A CA  1 
ATOM   94   C C   . LEU   A 1 36  ? -7.58421  59.38522 2.75231   1.000 21.32785 ? 154 LEU   A C   1 
ATOM   95   O O   . LEU   A 1 36  ? -7.20334  60.30596 2.02514   1.000 24.41056 ? 154 LEU   A O   1 
ATOM   96   C CB  . LEU   A 1 36  ? -6.88184  59.26852 5.15809   1.000 21.54383 ? 154 LEU   A CB  1 
ATOM   97   C CG  . LEU   A 1 36  ? -7.08513  59.66977 6.62279   1.000 28.51348 ? 154 LEU   A CG  1 
ATOM   98   C CD1 . LEU   A 1 36  ? -5.87853  59.23784 7.48336   1.000 25.53322 ? 154 LEU   A CD1 1 
ATOM   99   C CD2 . LEU   A 1 36  ? -7.37336  61.16984 6.76569   1.000 22.03039 ? 154 LEU   A CD2 1 
ATOM   100  N N   . MET   A 1 37  ? -7.58078  58.10555 2.35049   1.000 26.90800 ? 155 MET   A N   1 
ATOM   101  C CA  . MET   A 1 37  ? -7.16616  57.74022 0.99880   1.000 24.69848 ? 155 MET   A CA  1 
ATOM   102  C C   . MET   A 1 37  ? -8.11292  58.33236 -0.03712  1.000 30.69577 ? 155 MET   A C   1 
ATOM   103  O O   . MET   A 1 37  ? -7.67819  58.79447 -1.10095  1.000 26.98382 ? 155 MET   A O   1 
ATOM   104  C CB  . MET   A 1 37  ? -7.08710  56.21718 0.86277   1.000 23.69087 ? 155 MET   A CB  1 
ATOM   105  C CG  . MET   A 1 37  ? -5.87388  55.58418 1.55183   1.000 23.65229 ? 155 MET   A CG  1 
ATOM   106  S SD  . MET   A 1 37  ? -4.30178  56.18799 0.86809   1.000 28.12134 ? 155 MET   A SD  1 
ATOM   107  C CE  . MET   A 1 37  ? -4.33900  55.32971 -0.72575  1.000 35.00761 ? 155 MET   A CE  1 
ATOM   108  N N   . ASP   A 1 38  ? -9.40881  58.34269 0.27221   1.000 26.56655 ? 156 ASP   A N   1 
ATOM   109  C CA  . ASP   A 1 38  ? -10.38554 59.01684 -0.57148  1.000 26.73967 ? 156 ASP   A CA  1 
ATOM   110  C C   . ASP   A 1 38  ? -10.08000 60.50376 -0.68190  1.000 25.44836 ? 156 ASP   A C   1 
ATOM   111  O O   . ASP   A 1 38  ? -10.06332 61.06221 -1.78169  1.000 22.88627 ? 156 ASP   A O   1 
ATOM   112  C CB  . ASP   A 1 38  ? -11.79251 58.79792 -0.00400  1.000 27.81302 ? 156 ASP   A CB  1 
ATOM   113  C CG  . ASP   A 1 38  ? -12.88343 59.29062 -0.94674  1.000 34.24780 ? 156 ASP   A CG  1 
ATOM   114  O OD1 . ASP   A 1 38  ? -12.85254 58.89187 -2.12757  1.000 39.99869 ? 156 ASP   A OD1 1 
ATOM   115  O OD2 . ASP   A 1 38  ? -13.76883 60.06308 -0.51298  1.000 36.57161 ? 156 ASP   A OD2 1 
ATOM   116  N N   . ALA   A 1 39  ? -9.85768  61.16633 0.45885   1.000 25.17132 ? 157 ALA   A N   1 
ATOM   117  C CA  . ALA   A 1 39  ? -9.51979  62.58493 0.44401   1.000 26.55803 ? 157 ALA   A CA  1 
ATOM   118  C C   . ALA   A 1 39  ? -8.26879  62.84279 -0.39398  1.000 25.01802 ? 157 ALA   A C   1 
ATOM   119  O O   . ALA   A 1 39  ? -8.22351  63.79871 -1.18087  1.000 25.15140 ? 157 ALA   A O   1 
ATOM   120  C CB  . ALA   A 1 39  ? -9.32017  63.09381 1.87529   1.000 22.84119 ? 157 ALA   A CB  1 
ATOM   121  N N   . GLN   A 1 40  ? -7.24812  61.99439 -0.23956  1.000 23.47308 ? 158 GLN   A N   1 
ATOM   122  C CA  . GLN   A 1 40  ? -6.00534  62.15119 -0.99132  1.000 22.69018 ? 158 GLN   A CA  1 
ATOM   123  C C   . GLN   A 1 40  ? -6.24329  61.99456 -2.49658  1.000 25.32040 ? 158 GLN   A C   1 
ATOM   124  O O   . GLN   A 1 40  ? -5.78747  62.81595 -3.29873  1.000 23.70905 ? 158 GLN   A O   1 
ATOM   125  C CB  . GLN   A 1 40  ? -4.97984  61.12622 -0.48398  1.000 23.87749 ? 158 GLN   A CB  1 
ATOM   126  C CG  . GLN   A 1 40  ? -3.56294  61.24617 -1.07859  1.000 22.93852 ? 158 GLN   A CG  1 
ATOM   127  C CD  . GLN   A 1 40  ? -2.67546  62.22397 -0.32584  1.000 21.61193 ? 158 GLN   A CD  1 
ATOM   128  O OE1 . GLN   A 1 40  ? -3.08177  63.34462 -0.03398  1.000 22.58736 ? 158 GLN   A OE1 1 
ATOM   129  N NE2 . GLN   A 1 40  ? -1.43654  61.81245 -0.03014  1.000 21.72740 ? 158 GLN   A NE2 1 
ATOM   130  N N   . MET   A 1 41  ? -6.95057  60.93129 -2.89116  1.000 24.54798 ? 159 MET   A N   1 
ATOM   131  C CA  . MET   A 1 41  ? -7.27171  60.69741 -4.30415  1.000 26.38114 ? 159 MET   A CA  1 
ATOM   132  C C   . MET   A 1 41  ? -8.03144  61.87531 -4.90632  1.000 27.06836 ? 159 MET   A C   1 
ATOM   133  O O   . MET   A 1 41  ? -7.75535  62.30019 -6.03762  1.000 26.52233 ? 159 MET   A O   1 
ATOM   134  C CB  . MET   A 1 41  ? -8.08250  59.39865 -4.43589  1.000 25.91397 ? 159 MET   A CB  1 
ATOM   135  C CG  . MET   A 1 41  ? -8.59858  59.09403 -5.85496  1.000 31.45206 ? 159 MET   A CG  1 
ATOM   136  S SD  . MET   A 1 41  ? -10.23842 59.79190 -6.17176  1.000 31.14592 ? 159 MET   A SD  1 
ATOM   137  C CE  . MET   A 1 41  ? -11.31415 58.80999 -5.14928  1.000 25.14169 ? 159 MET   A CE  1 
ATOM   138  N N   . LYS   A 1 42  ? -8.97964  62.43139 -4.15888  1.000 27.42486 ? 160 LYS   A N   1 
ATOM   139  C CA  . LYS   A 1 42  ? -9.79378  63.50971 -4.70087  1.000 27.44855 ? 160 LYS   A CA  1 
ATOM   140  C C   . LYS   A 1 42  ? -9.02738  64.81537 -4.85691  1.000 26.71002 ? 160 LYS   A C   1 
ATOM   141  O O   . LYS   A 1 42  ? -9.43178  65.65061 -5.67072  1.000 26.78899 ? 160 LYS   A O   1 
ATOM   142  C CB  . LYS   A 1 42  ? -11.02401 63.73293 -3.81456  1.000 25.04607 ? 160 LYS   A CB  1 
ATOM   143  C CG  . LYS   A 1 42  ? -12.07855 62.65256 -3.96402  1.000 30.73120 ? 160 LYS   A CG  1 
ATOM   144  C CD  . LYS   A 1 42  ? -13.21532 62.78032 -2.93956  1.000 33.54752 ? 160 LYS   A CD  1 
ATOM   145  C CE  . LYS   A 1 42  ? -14.29820 61.73301 -3.23015  1.000 41.92896 ? 160 LYS   A CE  1 
ATOM   146  N NZ  . LYS   A 1 42  ? -15.31506 61.63174 -2.14700  1.000 42.42714 ? 160 LYS   A NZ  1 
ATOM   147  N N   . THR   A 1 43  ? -7.93183  65.02344 -4.11426  1.000 25.63607 ? 161 THR   A N   1 
ATOM   148  C CA  . THR   A 1 43  ? -7.38525  66.36947 -3.97731  1.000 23.20532 ? 161 THR   A CA  1 
ATOM   149  C C   . THR   A 1 43  ? -5.88718  66.48179 -4.27593  1.000 24.57382 ? 161 THR   A C   1 
ATOM   150  O O   . THR   A 1 43  ? -5.31763  67.57639 -4.10737  1.000 25.95487 ? 161 THR   A O   1 
ATOM   151  C CB  . THR   A 1 43  ? -7.64666  66.90079 -2.56578  1.000 23.60457 ? 161 THR   A CB  1 
ATOM   152  O OG1 . THR   A 1 43  ? -6.87971  66.13471 -1.63559  1.000 22.23500 ? 161 THR   A OG1 1 
ATOM   153  C CG2 . THR   A 1 43  ? -9.14933  66.79004 -2.21065  1.000 26.28106 ? 161 THR   A CG2 1 
ATOM   154  N N   . PHE   A 1 44  ? -5.23113  65.40369 -4.69401  1.000 21.76620 ? 162 PHE   A N   1 
ATOM   155  C CA  . PHE   A 1 44  ? -3.80877  65.42686 -5.02076  1.000 23.82072 ? 162 PHE   A CA  1 
ATOM   156  C C   . PHE   A 1 44  ? -3.70150  65.09010 -6.50792  1.000 25.15416 ? 162 PHE   A C   1 
ATOM   157  O O   . PHE   A 1 44  ? -3.86914  63.94020 -6.92846  1.000 25.72574 ? 162 PHE   A O   1 
ATOM   158  C CB  . PHE   A 1 44  ? -3.02497  64.50568 -4.05962  1.000 23.69719 ? 162 PHE   A CB  1 
ATOM   159  C CG  . PHE   A 1 44  ? -1.53796  64.40944 -4.32285  1.000 24.72439 ? 162 PHE   A CG  1 
ATOM   160  C CD1 . PHE   A 1 44  ? -0.84638  65.43336 -4.94890  1.000 27.40733 ? 162 PHE   A CD1 1 
ATOM   161  C CD2 . PHE   A 1 44  ? -0.79314  63.46806 -3.61816  1.000 22.34520 ? 162 PHE   A CD2 1 
ATOM   162  C CE1 . PHE   A 1 44  ? 0.53120   65.37832 -5.10318  1.000 24.95167 ? 162 PHE   A CE1 1 
ATOM   163  C CE2 . PHE   A 1 44  ? 0.60491   63.42868 -3.71002  1.000 20.92788 ? 162 PHE   A CE2 1 
ATOM   164  C CZ  . PHE   A 1 44  ? 1.26560   64.37205 -4.45410  1.000 23.85750 ? 162 PHE   A CZ  1 
ATOM   165  N N   . ASP   A 1 45  ? -3.51852  66.15573 -7.28280  1.000 30.31657 ? 163 ASP   A N   1 
ATOM   166  C CA  . ASP   A 1 45  ? -3.27952  66.15420 -8.72654  1.000 33.20788 ? 163 ASP   A CA  1 
ATOM   167  C C   . ASP   A 1 45  ? -1.83626  65.70296 -8.94208  1.000 22.58171 ? 163 ASP   A C   1 
ATOM   168  O O   . ASP   A 1 45  ? -0.90485  66.50986 -9.00076  1.000 28.77802 ? 163 ASP   A O   1 
ATOM   169  C CB  . ASP   A 1 45  ? -3.55004  67.57243 -9.23462  1.000 32.26579 ? 163 ASP   A CB  1 
ATOM   170  C CG  . ASP   A 1 45  ? -3.36142  67.74722 -10.73523 1.000 41.13823 ? 163 ASP   A CG  1 
ATOM   171  O OD1 . ASP   A 1 45  ? -3.25221  66.74304 -11.46910 1.000 33.11479 ? 163 ASP   A OD1 1 
ATOM   172  O OD2 . ASP   A 1 45  ? -3.38375  68.92811 -11.17430 1.000 35.12427 ? 163 ASP   A OD2 1 
ATOM   173  N N   . THR   A 1 46  ? -1.63676  64.37957 -8.97507  1.000 25.28036 ? 164 THR   A N   1 
ATOM   174  C CA  . THR   A 1 46  ? -0.26946  63.85324 -8.95289  1.000 28.39539 ? 164 THR   A CA  1 
ATOM   175  C C   . THR   A 1 46  ? 0.46119   64.06354 -10.27756 1.000 33.82154 ? 164 THR   A C   1 
ATOM   176  O O   . THR   A 1 46  ? 1.69309   63.95440 -10.31172 1.000 30.99277 ? 164 THR   A O   1 
ATOM   177  C CB  . THR   A 1 46  ? -0.22858  62.35836 -8.63734  1.000 29.33397 ? 164 THR   A CB  1 
ATOM   178  O OG1 . THR   A 1 46  ? -0.98083  61.64132 -9.61743  1.000 33.49715 ? 164 THR   A OG1 1 
ATOM   179  C CG2 . THR   A 1 46  ? -0.74038  62.04288 -7.18672  1.000 27.70866 ? 164 THR   A CG2 1 
ATOM   180  N N   . THR   A 1 47  ? -0.26847  64.31478 -11.36292 1.000 27.04547 ? 165 THR   A N   1 
ATOM   181  C CA  . THR   A 1 47  ? 0.32661   64.65995 -12.64539 1.000 26.97922 ? 165 THR   A CA  1 
ATOM   182  C C   . THR   A 1 47  ? 0.42874   66.16278 -12.84997 1.000 31.41977 ? 165 THR   A C   1 
ATOM   183  O O   . THR   A 1 47  ? 0.94530   66.59636 -13.88637 1.000 27.92928 ? 165 THR   A O   1 
ATOM   184  C CB  . THR   A 1 47  ? -0.49115  64.05389 -13.79698 1.000 30.65865 ? 165 THR   A CB  1 
ATOM   185  O OG1 . THR   A 1 47  ? -1.77767  64.67896 -13.85851 1.000 33.56009 ? 165 THR   A OG1 1 
ATOM   186  C CG2 . THR   A 1 47  ? -0.68339  62.57948 -13.60329 1.000 38.42689 ? 165 THR   A CG2 1 
ATOM   187  N N   . PHE   A 1 48  ? -0.07709  66.96094 -11.90212 1.000 29.84041 ? 166 PHE   A N   1 
ATOM   188  C CA  . PHE   A 1 48  ? -0.01472  68.42278 -11.96504 1.000 29.49011 ? 166 PHE   A CA  1 
ATOM   189  C C   . PHE   A 1 48  ? -0.69139  68.96494 -13.22774 1.000 30.63358 ? 166 PHE   A C   1 
ATOM   190  O O   . PHE   A 1 48  ? -0.33314  70.03847 -13.73170 1.000 28.25892 ? 166 PHE   A O   1 
ATOM   191  C CB  . PHE   A 1 48  ? 1.43379   68.91258 -11.85759 1.000 26.25601 ? 166 PHE   A CB  1 
ATOM   192  C CG  . PHE   A 1 48  ? 2.06507   68.65969 -10.49348 1.000 29.17033 ? 166 PHE   A CG  1 
ATOM   193  C CD1 . PHE   A 1 48  ? 2.42236   67.37635 -10.09729 1.000 29.43546 ? 166 PHE   A CD1 1 
ATOM   194  C CD2 . PHE   A 1 48  ? 2.26406   69.70683 -9.60408  1.000 30.06923 ? 166 PHE   A CD2 1 
ATOM   195  C CE1 . PHE   A 1 48  ? 2.99431   67.15108 -8.84262  1.000 26.58547 ? 166 PHE   A CE1 1 
ATOM   196  C CE2 . PHE   A 1 48  ? 2.83908   69.48592 -8.34765  1.000 26.04669 ? 166 PHE   A CE2 1 
ATOM   197  C CZ  . PHE   A 1 48  ? 3.20741   68.21238 -7.97786  1.000 22.83390 ? 166 PHE   A CZ  1 
ATOM   198  N N   . SER   A 1 49  ? -1.69750  68.23642 -13.72675 1.000 26.05258 ? 167 SER   A N   1 
ATOM   199  C CA  . SER   A 1 49  ? -2.31598  68.59078 -15.00236 1.000 31.82669 ? 167 SER   A CA  1 
ATOM   200  C C   . SER   A 1 49  ? -2.99572  69.94648 -14.95310 1.000 31.53427 ? 167 SER   A C   1 
ATOM   201  O O   . SER   A 1 49  ? -3.08519  70.63097 -15.97660 1.000 32.43903 ? 167 SER   A O   1 
ATOM   202  C CB  . SER   A 1 49  ? -3.33741  67.53209 -15.41108 1.000 30.21382 ? 167 SER   A CB  1 
ATOM   203  O OG  . SER   A 1 49  ? -2.69327  66.31606 -15.68111 1.000 36.53911 ? 167 SER   A OG  1 
ATOM   204  N N   . HIS   A 1 50  ? -3.50061  70.34608 -13.79261 1.000 30.63776 ? 168 HIS   A N   1 
ATOM   205  C CA  . HIS   A 1 50  ? -4.23668  71.59295 -13.68270 1.000 36.06044 ? 168 HIS   A CA  1 
ATOM   206  C C   . HIS   A 1 50  ? -3.39642  72.72833 -13.12389 1.000 32.28133 ? 168 HIS   A C   1 
ATOM   207  O O   . HIS   A 1 50  ? -3.93492  73.79765 -12.83929 1.000 35.87265 ? 168 HIS   A O   1 
ATOM   208  C CB  . HIS   A 1 50  ? -5.49106  71.36757 -12.85284 1.000 33.78870 ? 168 HIS   A CB  1 
ATOM   209  C CG  . HIS   A 1 50  ? -6.33040  70.25236 -13.38589 1.000 41.22834 ? 168 HIS   A CG  1 
ATOM   210  N ND1 . HIS   A 1 50  ? -6.80456  70.24085 -14.68044 1.000 43.38272 ? 168 HIS   A ND1 1 
ATOM   211  C CD2 . HIS   A 1 50  ? -6.73848  69.09063 -12.82429 1.000 43.63930 ? 168 HIS   A CD2 1 
ATOM   212  C CE1 . HIS   A 1 50  ? -7.48783  69.12994 -14.88649 1.000 44.06391 ? 168 HIS   A CE1 1 
ATOM   213  N NE2 . HIS   A 1 50  ? -7.46312  68.41447 -13.77585 1.000 55.44711 ? 168 HIS   A NE2 1 
ATOM   214  N N   . PHE   A 1 51  ? -2.08879  72.53851 -13.00579 1.000 32.23688 ? 169 PHE   A N   1 
ATOM   215  C CA  . PHE   A 1 51  ? -1.18396  73.61971 -12.63044 1.000 28.80043 ? 169 PHE   A CA  1 
ATOM   216  C C   . PHE   A 1 51  ? -0.82049  74.36685 -13.90356 1.000 31.03629 ? 169 PHE   A C   1 
ATOM   217  O O   . PHE   A 1 51  ? -0.04758  73.86230 -14.72030 1.000 27.23485 ? 169 PHE   A O   1 
ATOM   218  C CB  . PHE   A 1 51  ? 0.06498   73.07933 -11.95026 1.000 26.90212 ? 169 PHE   A CB  1 
ATOM   219  C CG  . PHE   A 1 51  ? 1.04534   74.14459 -11.56029 1.000 28.72525 ? 169 PHE   A CG  1 
ATOM   220  C CD1 . PHE   A 1 51  ? 0.60245   75.34604 -11.01858 1.000 27.00702 ? 169 PHE   A CD1 1 
ATOM   221  C CD2 . PHE   A 1 51  ? 2.40639   73.93764 -11.70173 1.000 26.34272 ? 169 PHE   A CD2 1 
ATOM   222  C CE1 . PHE   A 1 51  ? 1.50743   76.32811 -10.63970 1.000 26.95501 ? 169 PHE   A CE1 1 
ATOM   223  C CE2 . PHE   A 1 51  ? 3.31656   74.91407 -11.31178 1.000 26.23152 ? 169 PHE   A CE2 1 
ATOM   224  C CZ  . PHE   A 1 51  ? 2.86273   76.11008 -10.79241 1.000 27.77665 ? 169 PHE   A CZ  1 
ATOM   225  N N   . LYS   A 1 52  ? -1.36815  75.56518 -14.06978 1.000 34.69805 ? 170 LYS   A N   1 
ATOM   226  C CA  . LYS   A 1 52  ? -1.21851  76.30133 -15.31715 1.000 40.68206 ? 170 LYS   A CA  1 
ATOM   227  C C   . LYS   A 1 52  ? -1.04202  77.78155 -15.00758 1.000 37.92225 ? 170 LYS   A C   1 
ATOM   228  O O   . LYS   A 1 52  ? -1.22622  78.22550 -13.87287 1.000 39.45911 ? 170 LYS   A O   1 
ATOM   229  C CB  . LYS   A 1 52  ? -2.43705  76.09025 -16.22512 1.000 43.78565 ? 170 LYS   A CB  1 
ATOM   230  C CG  . LYS   A 1 52  ? -2.54306  74.70996 -16.83054 1.000 48.37378 ? 170 LYS   A CG  1 
ATOM   231  C CD  . LYS   A 1 52  ? -3.94167  74.47583 -17.43227 1.000 50.50253 ? 170 LYS   A CD  1 
ATOM   232  C CE  . LYS   A 1 52  ? -4.07239  73.07931 -18.03973 1.000 44.85665 ? 170 LYS   A CE  1 
ATOM   233  N NZ  . LYS   A 1 52  ? -2.74624  72.56016 -18.48979 1.000 55.04323 ? 170 LYS   A NZ  1 
ATOM   234  N N   . ASN   A 1 53  ? -0.68517  78.54855 -16.04073 1.000 39.08871 ? 171 ASN   A N   1 
ATOM   235  C CA  . ASN   A 1 53  ? -0.61142  80.00843 -15.95468 1.000 41.96031 ? 171 ASN   A CA  1 
ATOM   236  C C   . ASN   A 1 53  ? 0.34796   80.47242 -14.86206 1.000 38.41850 ? 171 ASN   A C   1 
ATOM   237  O O   . ASN   A 1 53  ? 0.12069   81.49049 -14.21167 1.000 39.98050 ? 171 ASN   A O   1 
ATOM   238  C CB  . ASN   A 1 53  ? -2.00186  80.62058 -15.74544 1.000 40.37803 ? 171 ASN   A CB  1 
ATOM   239  C CG  . ASN   A 1 53  ? -3.00915  80.13527 -16.77757 1.000 49.32092 ? 171 ASN   A CG  1 
ATOM   240  O OD1 . ASN   A 1 53  ? -2.70857  80.08228 -17.96802 1.000 49.09047 ? 171 ASN   A OD1 1 
ATOM   241  N ND2 . ASN   A 1 53  ? -4.20604  79.78165 -16.32581 1.000 49.98860 ? 171 ASN   A ND2 1 
ATOM   242  N N   . PHE   A 1 54  ? 1.42618   79.73206 -14.64987 1.000 34.12317 ? 172 PHE   A N   1 
ATOM   243  C CA  . PHE   A 1 54  ? 2.41077   80.10744 -13.65109 1.000 34.28889 ? 172 PHE   A CA  1 
ATOM   244  C C   . PHE   A 1 54  ? 3.45400   81.02119 -14.28072 1.000 31.93349 ? 172 PHE   A C   1 
ATOM   245  O O   . PHE   A 1 54  ? 3.68682   80.99755 -15.48993 1.000 32.87986 ? 172 PHE   A O   1 
ATOM   246  C CB  . PHE   A 1 54  ? 3.08647   78.86628 -13.06379 1.000 29.17193 ? 172 PHE   A CB  1 
ATOM   247  C CG  . PHE   A 1 54  ? 3.44942   77.83444 -14.09937 1.000 33.03587 ? 172 PHE   A CG  1 
ATOM   248  C CD1 . PHE   A 1 54  ? 4.55139   78.01014 -14.92127 1.000 27.68282 ? 172 PHE   A CD1 1 
ATOM   249  C CD2 . PHE   A 1 54  ? 2.66528   76.70287 -14.26886 1.000 31.25411 ? 172 PHE   A CD2 1 
ATOM   250  C CE1 . PHE   A 1 54  ? 4.86184   77.07599 -15.89151 1.000 31.48754 ? 172 PHE   A CE1 1 
ATOM   251  C CE2 . PHE   A 1 54  ? 2.97401   75.75759 -15.22327 1.000 28.47386 ? 172 PHE   A CE2 1 
ATOM   252  C CZ  . PHE   A 1 54  ? 4.07781   75.94090 -16.04251 1.000 33.02319 ? 172 PHE   A CZ  1 
ATOM   253  N N   . ARG   A 1 55  ? 4.07822   81.83396 -13.44084 1.000 29.91289 ? 173 ARG   A N   1 
ATOM   254  C CA  . ARG   A 1 55  ? 5.19976   82.63927 -13.88832 1.000 30.82471 ? 173 ARG   A CA  1 
ATOM   255  C C   . ARG   A 1 55  ? 6.44979   81.77411 -14.06148 1.000 34.61828 ? 173 ARG   A C   1 
ATOM   256  O O   . ARG   A 1 55  ? 6.55964   80.67345 -13.50893 1.000 25.57591 ? 173 ARG   A O   1 
ATOM   257  C CB  . ARG   A 1 55  ? 5.45283   83.77413 -12.89772 1.000 32.42005 ? 173 ARG   A CB  1 
ATOM   258  C CG  . ARG   A 1 55  ? 4.24164   84.71090 -12.73564 1.000 32.59553 ? 173 ARG   A CG  1 
ATOM   259  C CD  . ARG   A 1 55  ? 4.38060   85.58959 -11.50161 1.000 32.40222 ? 173 ARG   A CD  1 
ATOM   260  N NE  . ARG   A 1 55  ? 3.90407   84.89874 -10.30745 1.000 30.30790 ? 173 ARG   A NE  1 
ATOM   261  C CZ  . ARG   A 1 55  ? 3.88091   85.43763 -9.09193  1.000 33.73512 ? 173 ARG   A CZ  1 
ATOM   262  N NH1 . ARG   A 1 55  ? 4.31611   86.67129 -8.92109  1.000 28.65988 ? 173 ARG   A NH1 1 
ATOM   263  N NH2 . ARG   A 1 55  ? 3.43424   84.74045 -8.04280  1.000 29.06034 ? 173 ARG   A NH2 1 
ATOM   264  N N   . LEU   A 1 56  ? 7.39144   82.28063 -14.85892 1.000 28.61083 ? 174 LEU   A N   1 
ATOM   265  C CA  . LEU   A 1 56  ? 8.66232   81.62572 -15.13096 1.000 30.25546 ? 174 LEU   A CA  1 
ATOM   266  C C   . LEU   A 1 56  ? 9.78639   82.64672 -15.02710 1.000 38.43007 ? 174 LEU   A C   1 
ATOM   267  O O   . LEU   A 1 56  ? 9.55689   83.84748 -15.21153 1.000 37.06092 ? 174 LEU   A O   1 
ATOM   268  C CB  . LEU   A 1 56  ? 8.67116   80.97958 -16.52545 1.000 33.63627 ? 174 LEU   A CB  1 
ATOM   269  C CG  . LEU   A 1 56  ? 7.72725   79.78025 -16.65986 1.000 32.81618 ? 174 LEU   A CG  1 
ATOM   270  C CD1 . LEU   A 1 56  ? 7.57910   79.33680 -18.11799 1.000 36.96113 ? 174 LEU   A CD1 1 
ATOM   271  C CD2 . LEU   A 1 56  ? 8.20530   78.64073 -15.79530 1.000 32.66582 ? 174 LEU   A CD2 1 
ATOM   272  N N   . PRO   A 1 57  ? 10.99885  82.20709 -14.70210 1.000 32.02871 ? 175 PRO   A N   1 
ATOM   273  C CA  . PRO   A 1 57  ? 12.11754  83.15174 -14.60575 1.000 35.13726 ? 175 PRO   A CA  1 
ATOM   274  C C   . PRO   A 1 57  ? 12.31593  83.88882 -15.92552 1.000 47.48191 ? 175 PRO   A C   1 
ATOM   275  O O   . PRO   A 1 57  ? 12.22731  83.29778 -17.00765 1.000 44.78868 ? 175 PRO   A O   1 
ATOM   276  C CB  . PRO   A 1 57  ? 13.31997  82.25567 -14.28257 1.000 37.39642 ? 175 PRO   A CB  1 
ATOM   277  C CG  . PRO   A 1 57  ? 12.76345  80.98573 -13.82544 1.000 37.42680 ? 175 PRO   A CG  1 
ATOM   278  C CD  . PRO   A 1 57  ? 11.41035  80.82001 -14.42362 1.000 31.58027 ? 175 PRO   A CD  1 
ATOM   279  N N   . GLY   A 1 58  ? 12.57910  85.19371 -15.82056 1.000 50.88627 ? 176 GLY   A N   1 
ATOM   280  C CA  . GLY   A 1 58  ? 12.70291  86.07088 -16.96877 1.000 51.95917 ? 176 GLY   A CA  1 
ATOM   281  C C   . GLY   A 1 58  ? 13.64787  85.56252 -18.03479 1.000 50.90392 ? 176 GLY   A C   1 
ATOM   282  O O   . GLY   A 1 58  ? 14.63871  84.89183 -17.72923 1.000 52.95397 ? 176 GLY   A O   1 
ATOM   283  N N   . VAL   A 1 59  ? 13.34038  85.86889 -19.29237 1.000 58.93504 ? 177 VAL   A N   1 
ATOM   284  C CA  . VAL   A 1 59  ? 14.15704  85.44419 -20.42511 1.000 58.54100 ? 177 VAL   A CA  1 
ATOM   285  C C   . VAL   A 1 59  ? 14.98983  86.60683 -20.95647 1.000 68.56594 ? 177 VAL   A C   1 
ATOM   286  O O   . VAL   A 1 59  ? 16.13264  86.80806 -20.54189 1.000 68.04072 ? 177 VAL   A O   1 
ATOM   287  C CB  . VAL   A 1 59  ? 13.28283  84.85541 -21.54442 1.000 63.28146 ? 177 VAL   A CB  1 
ATOM   288  N N   . SER   A 1 90  ? 20.82919  79.73500 -1.22603  1.000 63.70061 ? 208 SER   A N   1 
ATOM   289  C CA  . SER   A 1 90  ? 21.54278  78.52036 -0.84585  1.000 69.50516 ? 208 SER   A CA  1 
ATOM   290  C C   . SER   A 1 90  ? 21.55937  77.48814 -1.98064  1.000 72.91041 ? 208 SER   A C   1 
ATOM   291  O O   . SER   A 1 90  ? 22.32779  77.61813 -2.93658  1.000 67.30243 ? 208 SER   A O   1 
ATOM   292  C CB  . SER   A 1 90  ? 20.91734  77.91057 0.41118   1.000 66.28551 ? 208 SER   A CB  1 
ATOM   293  N N   . LEU   A 1 91  ? 20.71016  76.46545 -1.86356  1.000 70.77706 ? 209 LEU   A N   1 
ATOM   294  C CA  . LEU   A 1 91  ? 20.62634  75.41112 -2.86985  1.000 65.04847 ? 209 LEU   A CA  1 
ATOM   295  C C   . LEU   A 1 91  ? 19.69958  75.81827 -4.01671  1.000 66.41202 ? 209 LEU   A C   1 
ATOM   296  O O   . LEU   A 1 91  ? 18.65202  76.43531 -3.79853  1.000 63.73598 ? 209 LEU   A O   1 
ATOM   297  C CB  . LEU   A 1 91  ? 20.13268  74.11182 -2.22946  1.000 59.39313 ? 209 LEU   A CB  1 
ATOM   298  N N   . LYS   A 1 92  ? 20.08661  75.46134 -5.24439  1.000 58.93612 ? 210 LYS   A N   1 
ATOM   299  C CA  . LYS   A 1 92  ? 19.35245  75.84506 -6.44362  1.000 59.88373 ? 210 LYS   A CA  1 
ATOM   300  C C   . LYS   A 1 92  ? 18.80339  74.61792 -7.16549  1.000 52.92151 ? 210 LYS   A C   1 
ATOM   301  O O   . LYS   A 1 92  ? 19.31714  73.50239 -7.03375  1.000 51.16223 ? 210 LYS   A O   1 
ATOM   302  C CB  . LYS   A 1 92  ? 20.23347  76.66163 -7.41045  1.000 51.65313 ? 210 LYS   A CB  1 
ATOM   303  C CG  . LYS   A 1 92  ? 20.94486  77.85282 -6.77394  1.000 61.12287 ? 210 LYS   A CG  1 
ATOM   304  N N   . VAL   A 1 93  ? 17.73255  74.83423 -7.92882  1.000 41.35781 ? 211 VAL   A N   1 
ATOM   305  C CA  . VAL   A 1 93  ? 17.16003  73.80166 -8.77805  1.000 36.88413 ? 211 VAL   A CA  1 
ATOM   306  C C   . VAL   A 1 93  ? 17.08637  74.32658 -10.20728 1.000 34.74551 ? 211 VAL   A C   1 
ATOM   307  O O   . VAL   A 1 93  ? 16.86045  75.51899 -10.44010 1.000 38.67911 ? 211 VAL   A O   1 
ATOM   308  C CB  . VAL   A 1 93  ? 15.76662  73.34064 -8.28882  1.000 37.41777 ? 211 VAL   A CB  1 
ATOM   309  C CG1 . VAL   A 1 93  ? 15.80253  73.01295 -6.80580  1.000 45.18302 ? 211 VAL   A CG1 1 
ATOM   310  C CG2 . VAL   A 1 93  ? 14.71218  74.40923 -8.55912  1.000 40.30155 ? 211 VAL   A CG2 1 
ATOM   311  N N   . SER   A 1 94  ? 17.31530  73.43307 -11.15395 1.000 32.47694 ? 212 SER   A N   1 
ATOM   312  C CA  . SER   A 1 94  ? 16.92842  73.68058 -12.52516 1.000 34.64269 ? 212 SER   A CA  1 
ATOM   313  C C   . SER   A 1 94  ? 15.47061  73.28408 -12.70321 1.000 39.33954 ? 212 SER   A C   1 
ATOM   314  O O   . SER   A 1 94  ? 14.89114  72.54420 -11.89938 1.000 33.48991 ? 212 SER   A O   1 
ATOM   315  C CB  . SER   A 1 94  ? 17.81451  72.89932 -13.48974 1.000 34.23285 ? 212 SER   A CB  1 
ATOM   316  O OG  . SER   A 1 94  ? 17.82584  71.52460 -13.16867 1.000 38.66472 ? 212 SER   A OG  1 
ATOM   317  N N   . LEU   A 1 95  ? 14.88077  73.78764 -13.77124 1.000 30.67401 ? 213 LEU   A N   1 
ATOM   318  C CA  . LEU   A 1 95  ? 13.47801  73.58646 -14.06983 1.000 30.84771 ? 213 LEU   A CA  1 
ATOM   319  C C   . LEU   A 1 95  ? 13.33871  73.12160 -15.51299 1.000 39.35659 ? 213 LEU   A C   1 
ATOM   320  O O   . LEU   A 1 95  ? 13.88535  73.75009 -16.43006 1.000 33.91950 ? 213 LEU   A O   1 
ATOM   321  C CB  . LEU   A 1 95  ? 12.71945  74.88912 -13.78368 1.000 31.57248 ? 213 LEU   A CB  1 
ATOM   322  C CG  . LEU   A 1 95  ? 11.26799  75.12147 -14.17596 1.000 39.25763 ? 213 LEU   A CG  1 
ATOM   323  C CD1 . LEU   A 1 95  ? 10.53010  75.98429 -13.18717 1.000 41.08581 ? 213 LEU   A CD1 1 
ATOM   324  C CD2 . LEU   A 1 95  ? 11.38447  75.89028 -15.43563 1.000 47.07496 ? 213 LEU   A CD2 1 
ATOM   325  N N   . GLN   A 1 96  ? 12.64310  72.00512 -15.70990 1.000 32.76655 ? 214 GLN   A N   1 
ATOM   326  C CA  . GLN   A 1 96  ? 12.37568  71.46790 -17.03558 1.000 34.94439 ? 214 GLN   A CA  1 
ATOM   327  C C   . GLN   A 1 96  ? 10.87084  71.39378 -17.26452 1.000 38.29474 ? 214 GLN   A C   1 
ATOM   328  O O   . GLN   A 1 96  ? 10.11947  70.96362 -16.38073 1.000 36.80023 ? 214 GLN   A O   1 
ATOM   329  C CB  . GLN   A 1 96  ? 13.00086  70.08132 -17.21081 1.000 35.25999 ? 214 GLN   A CB  1 
ATOM   330  C CG  . GLN   A 1 96  ? 12.54187  69.37867 -18.47257 1.000 36.32396 ? 214 GLN   A CG  1 
ATOM   331  C CD  . GLN   A 1 96  ? 13.38562  68.17756 -18.83253 1.000 45.58678 ? 214 GLN   A CD  1 
ATOM   332  O OE1 . GLN   A 1 96  ? 14.61397  68.22765 -18.77975 1.000 48.61888 ? 214 GLN   A OE1 1 
ATOM   333  N NE2 . GLN   A 1 96  ? 12.72865  67.08688 -19.21332 1.000 50.91520 ? 214 GLN   A NE2 1 
ATOM   334  N N   . LEU   A 1 97  ? 10.43392  71.82331 -18.45223 1.000 31.06375 ? 215 LEU   A N   1 
ATOM   335  C CA  . LEU   A 1 97  ? 9.02593   71.83408 -18.85303 1.000 31.06175 ? 215 LEU   A CA  1 
ATOM   336  C C   . LEU   A 1 97  ? 8.88269   71.04040 -20.13786 1.000 38.04907 ? 215 LEU   A C   1 
ATOM   337  O O   . LEU   A 1 97  ? 9.36480   71.47798 -21.19398 1.000 31.51680 ? 215 LEU   A O   1 
ATOM   338  C CB  . LEU   A 1 97  ? 8.51269   73.24174 -19.11423 1.000 38.33574 ? 215 LEU   A CB  1 
ATOM   339  C CG  . LEU   A 1 97  ? 8.19601   74.24024 -18.03828 1.000 50.27077 ? 215 LEU   A CG  1 
ATOM   340  C CD1 . LEU   A 1 97  ? 9.47628   74.92395 -17.82600 1.000 45.59575 ? 215 LEU   A CD1 1 
ATOM   341  C CD2 . LEU   A 1 97  ? 7.14667   75.21683 -18.53816 1.000 54.21984 ? 215 LEU   A CD2 1 
ATOM   342  N N   . ARG   A 1 98  ? 8.19313   69.90947 -20.06625 1.000 32.07030 ? 216 ARG   A N   1 
ATOM   343  C CA  A ARG   A 1 98  ? 7.97399   69.07925 -21.24104 0.853 34.23378 ? 216 ARG   A CA  1 
ATOM   344  C C   . ARG   A 1 98  ? 6.63612   69.46027 -21.85049 1.000 46.04579 ? 216 ARG   A C   1 
ATOM   345  O O   . ARG   A 1 98  ? 5.60507   69.41389 -21.17021 1.000 51.38103 ? 216 ARG   A O   1 
ATOM   346  C CB  A ARG   A 1 98  ? 8.02320   67.59650 -20.88022 0.853 30.47020 ? 216 ARG   A CB  1 
ATOM   347  C CG  A ARG   A 1 98  ? 9.46232   67.11227 -20.66289 0.853 38.30033 ? 216 ARG   A CG  1 
ATOM   348  C CD  A ARG   A 1 98  ? 9.55606   65.67520 -20.15711 0.853 37.39122 ? 216 ARG   A CD  1 
ATOM   349  N NE  A ARG   A 1 98  ? 8.83845   65.45650 -18.89795 0.853 43.15984 ? 216 ARG   A NE  1 
ATOM   350  C CZ  A ARG   A 1 98  ? 9.11256   66.04114 -17.72713 0.853 44.92912 ? 216 ARG   A CZ  1 
ATOM   351  N NH1 A ARG   A 1 98  ? 10.11762  66.91346 -17.58788 0.853 38.49939 ? 216 ARG   A NH1 1 
ATOM   352  N NH2 A ARG   A 1 98  ? 8.37074   65.74235 -16.66996 0.853 42.31789 ? 216 ARG   A NH2 1 
ATOM   353  N N   . GLY   A 1 99  ? 6.65801   69.87341 -23.11595 1.000 39.73731 ? 217 GLY   A N   1 
ATOM   354  C CA  . GLY   A 1 99  ? 5.43623   70.28035 -23.77193 1.000 40.98939 ? 217 GLY   A CA  1 
ATOM   355  C C   . GLY   A 1 99  ? 4.65212   69.08832 -24.27948 1.000 40.58780 ? 217 GLY   A C   1 
ATOM   356  O O   . GLY   A 1 99  ? 5.20413   68.03318 -24.58462 1.000 39.39150 ? 217 GLY   A O   1 
ATOM   357  N N   . GLU   A 1 100 ? 3.33375   69.26917 -24.36686 1.000 50.62605 ? 218 GLU   A N   1 
ATOM   358  C CA  . GLU   A 1 100 ? 2.47734   68.22291 -24.91589 1.000 47.68702 ? 218 GLU   A CA  1 
ATOM   359  C C   . GLU   A 1 100 ? 2.89263   67.80995 -26.32784 1.000 52.17992 ? 218 GLU   A C   1 
ATOM   360  O O   . GLU   A 1 100 ? 2.60969   66.67980 -26.73637 1.000 52.00799 ? 218 GLU   A O   1 
ATOM   361  C CB  . GLU   A 1 100 ? 1.01954   68.68861 -24.90558 1.000 49.92723 ? 218 GLU   A CB  1 
ATOM   362  N N   . ASP   A 1 101 ? 3.58059   68.68282 -27.06976 1.000 47.92977 ? 219 ASP   A N   1 
ATOM   363  C CA  . ASP   A 1 101 ? 4.04617   68.37006 -28.41315 1.000 45.37855 ? 219 ASP   A CA  1 
ATOM   364  C C   . ASP   A 1 101 ? 5.38885   67.65672 -28.42827 1.000 48.06274 ? 219 ASP   A C   1 
ATOM   365  O O   . ASP   A 1 101 ? 5.88167   67.31986 -29.50898 1.000 50.18992 ? 219 ASP   A O   1 
ATOM   366  C CB  . ASP   A 1 101 ? 4.14987   69.64994 -29.25247 1.000 47.44677 ? 219 ASP   A CB  1 
ATOM   367  C CG  . ASP   A 1 101 ? 5.03849   70.70165 -28.61396 1.000 53.23568 ? 219 ASP   A CG  1 
ATOM   368  O OD1 . ASP   A 1 101 ? 5.68637   70.40993 -27.58017 1.000 52.11651 ? 219 ASP   A OD1 1 
ATOM   369  O OD2 . ASP   A 1 101 ? 5.09605   71.82883 -29.15215 1.000 57.07459 ? 219 ASP   A OD2 1 
ATOM   370  N N   . GLY   A 1 102 ? 6.00391   67.43634 -27.27153 1.000 41.95904 ? 220 GLY   A N   1 
ATOM   371  C CA  . GLY   A 1 102 ? 7.31380   66.82761 -27.21458 1.000 44.12123 ? 220 GLY   A CA  1 
ATOM   372  C C   . GLY   A 1 102 ? 8.46108   67.80768 -27.11701 1.000 39.45959 ? 220 GLY   A C   1 
ATOM   373  O O   . GLY   A 1 102 ? 9.60568   67.37643 -26.94620 1.000 40.39816 ? 220 GLY   A O   1 
ATOM   374  N N   . SER   A 1 103 ? 8.19472   69.10681 -27.22018 1.000 41.32955 ? 221 SER   A N   1 
ATOM   375  C CA  . SER   A 1 103 ? 9.23976   70.08999 -26.97365 1.000 39.58935 ? 221 SER   A CA  1 
ATOM   376  C C   . SER   A 1 103 ? 9.61293   70.10404 -25.49281 1.000 38.50245 ? 221 SER   A C   1 
ATOM   377  O O   . SER   A 1 103 ? 8.81540   69.73672 -24.62059 1.000 34.89533 ? 221 SER   A O   1 
ATOM   378  C CB  . SER   A 1 103 ? 8.78278   71.47756 -27.42508 1.000 40.36052 ? 221 SER   A CB  1 
ATOM   379  O OG  . SER   A 1 103 ? 7.66982   71.93701 -26.67723 1.000 41.18545 ? 221 SER   A OG  1 
ATOM   380  N N   . VAL   A 1 104 ? 10.84470  70.51365 -25.20847 1.000 32.46783 ? 222 VAL   A N   1 
ATOM   381  C CA  . VAL   A 1 104 ? 11.30766  70.67641 -23.83704 1.000 32.73148 ? 222 VAL   A CA  1 
ATOM   382  C C   . VAL   A 1 104 ? 12.00139  72.02352 -23.68685 1.000 36.45145 ? 222 VAL   A C   1 
ATOM   383  O O   . VAL   A 1 104 ? 12.91486  72.34203 -24.45348 1.000 36.19258 ? 222 VAL   A O   1 
ATOM   384  C CB  . VAL   A 1 104 ? 12.25882  69.54193 -23.41064 1.000 35.49695 ? 222 VAL   A CB  1 
ATOM   385  C CG1 . VAL   A 1 104 ? 12.58702  69.68657 -21.95089 1.000 37.55095 ? 222 VAL   A CG1 1 
ATOM   386  C CG2 . VAL   A 1 104 ? 11.62531  68.18301 -23.67060 1.000 38.95922 ? 222 VAL   A CG2 1 
ATOM   387  N N   . TRP   A 1 105 ? 11.57319  72.80652 -22.69140 1.000 27.70617 ? 223 TRP   A N   1 
ATOM   388  C CA  . TRP   A 1 105 ? 12.32241  73.95259 -22.19206 1.000 26.72739 ? 223 TRP   A CA  1 
ATOM   389  C C   . TRP   A 1 105 ? 13.05532  73.53745 -20.91439 1.000 37.47393 ? 223 TRP   A C   1 
ATOM   390  O O   . TRP   A 1 105 ? 12.47313  72.85147 -20.06492 1.000 34.13629 ? 223 TRP   A O   1 
ATOM   391  C CB  . TRP   A 1 105 ? 11.37809  75.11387 -21.88132 1.000 29.75977 ? 223 TRP   A CB  1 
ATOM   392  C CG  . TRP   A 1 105 ? 10.91455  75.98727 -23.01864 1.000 37.70677 ? 223 TRP   A CG  1 
ATOM   393  C CD1 . TRP   A 1 105 ? 9.67438   75.98871 -23.60772 1.000 39.48088 ? 223 TRP   A CD1 1 
ATOM   394  C CD2 . TRP   A 1 105 ? 11.65364  77.04257 -23.64867 1.000 33.11901 ? 223 TRP   A CD2 1 
ATOM   395  N NE1 . TRP   A 1 105 ? 9.60918   76.96719 -24.57683 1.000 36.34663 ? 223 TRP   A NE1 1 
ATOM   396  C CE2 . TRP   A 1 105 ? 10.80982  77.62740 -24.61822 1.000 34.02287 ? 223 TRP   A CE2 1 
ATOM   397  C CE3 . TRP   A 1 105 ? 12.94576  77.54523 -23.48905 1.000 33.41437 ? 223 TRP   A CE3 1 
ATOM   398  C CZ2 . TRP   A 1 105 ? 11.22585  78.68468 -25.42692 1.000 34.88079 ? 223 TRP   A CZ2 1 
ATOM   399  C CZ3 . TRP   A 1 105 ? 13.35371  78.59378 -24.29414 1.000 37.07355 ? 223 TRP   A CZ3 1 
ATOM   400  C CH2 . TRP   A 1 105 ? 12.49412  79.15061 -25.24782 1.000 26.83095 ? 223 TRP   A CH2 1 
ATOM   401  N N   . ASN   A 1 106 ? 14.32569  73.93796 -20.78059 1.000 32.87227 ? 224 ASN   A N   1 
ATOM   402  C CA  . ASN   A 1 106 ? 15.10751  73.77328 -19.54911 1.000 28.68732 ? 224 ASN   A CA  1 
ATOM   403  C C   . ASN   A 1 106 ? 15.67770  75.10537 -19.10602 1.000 37.59909 ? 224 ASN   A C   1 
ATOM   404  O O   . ASN   A 1 106 ? 16.24521  75.84776 -19.91161 1.000 32.19197 ? 224 ASN   A O   1 
ATOM   405  C CB  . ASN   A 1 106 ? 16.29711  72.80402 -19.68166 1.000 37.85541 ? 224 ASN   A CB  1 
ATOM   406  C CG  . ASN   A 1 106 ? 15.94325  71.36229 -19.39769 1.000 49.07379 ? 224 ASN   A CG  1 
ATOM   407  O OD1 . ASN   A 1 106 ? 15.62552  70.58640 -20.29961 1.000 52.68276 ? 224 ASN   A OD1 1 
ATOM   408  N ND2 . ASN   A 1 106 ? 16.06277  70.97466 -18.12765 1.000 49.22258 ? 224 ASN   A ND2 1 
ATOM   409  N N   . TYR   A 1 107 ? 15.55889  75.37922 -17.81174 1.000 29.15139 ? 225 TYR   A N   1 
ATOM   410  C CA  . TYR   A 1 107 ? 16.11523  76.57406 -17.19996 1.000 32.22808 ? 225 TYR   A CA  1 
ATOM   411  C C   . TYR   A 1 107 ? 17.19800  76.15002 -16.22444 1.000 40.52238 ? 225 TYR   A C   1 
ATOM   412  O O   . TYR   A 1 107 ? 16.92505  75.38007 -15.28907 1.000 36.26717 ? 225 TYR   A O   1 
ATOM   413  C CB  . TYR   A 1 107 ? 15.03374  77.37524 -16.48061 1.000 29.65736 ? 225 TYR   A CB  1 
ATOM   414  C CG  . TYR   A 1 107 ? 15.56452  78.56750 -15.70052 1.000 35.99905 ? 225 TYR   A CG  1 
ATOM   415  C CD1 . TYR   A 1 107 ? 15.80994  79.77836 -16.33664 1.000 33.84249 ? 225 TYR   A CD1 1 
ATOM   416  C CD2 . TYR   A 1 107 ? 15.80761  78.48361 -14.33043 1.000 36.96618 ? 225 TYR   A CD2 1 
ATOM   417  C CE1 . TYR   A 1 107 ? 16.27621  80.86911 -15.64989 1.000 36.00357 ? 225 TYR   A CE1 1 
ATOM   418  C CE2 . TYR   A 1 107 ? 16.28083  79.57928 -13.61841 1.000 40.70551 ? 225 TYR   A CE2 1 
ATOM   419  C CZ  . TYR   A 1 107 ? 16.50956  80.76997 -14.28316 1.000 41.40328 ? 225 TYR   A CZ  1 
ATOM   420  O OH  . TYR   A 1 107 ? 16.97636  81.87445 -13.61767 1.000 41.37914 ? 225 TYR   A OH  1 
ATOM   421  N N   . LYS   A 1 108 ? 18.44120  76.63934 -16.45821 1.000 32.06542 ? 226 LYS   A N   1 
ATOM   422  C CA  . LYS   A 1 108 ? 19.51763  76.47847 -15.48431 1.000 40.86922 ? 226 LYS   A CA  1 
ATOM   423  C C   . LYS   A 1 108 ? 19.72421  77.79408 -14.75856 1.000 46.16400 ? 226 LYS   A C   1 
ATOM   424  O O   . LYS   A 1 108 ? 19.87264  78.84120 -15.41234 1.000 39.15566 ? 226 LYS   A O   1 
ATOM   425  C CB  . LYS   A 1 108 ? 20.81928  76.03976 -16.15362 1.000 44.72046 ? 226 LYS   A CB  1 
ATOM   426  C CG  . LYS   A 1 108 ? 22.05642  76.30725 -15.31493 1.000 52.03895 ? 226 LYS   A CG  1 
ATOM   427  N N   . PRO   A 1 109 ? 19.71819  77.77700 -13.42808 1.000 43.14316 ? 227 PRO   A N   1 
ATOM   428  C CA  . PRO   A 1 109 ? 19.68531  79.02133 -12.65437 1.000 43.91995 ? 227 PRO   A CA  1 
ATOM   429  C C   . PRO   A 1 109 ? 21.00319  79.77257 -12.73419 1.000 47.34181 ? 227 PRO   A C   1 
ATOM   430  O O   . PRO   A 1 109 ? 22.02956  79.21651 -13.15629 1.000 48.88195 ? 227 PRO   A O   1 
ATOM   431  C CB  . PRO   A 1 109 ? 19.40833  78.53289 -11.22160 1.000 43.32506 ? 227 PRO   A CB  1 
ATOM   432  C CG  . PRO   A 1 109 ? 19.89459  77.11477 -11.21021 1.000 48.80984 ? 227 PRO   A CG  1 
ATOM   433  C CD  . PRO   A 1 109 ? 19.56511  76.58715 -12.57196 1.000 46.62361 ? 227 PRO   A CD  1 
ATOM   434  N N   . PRO   A 1 110 ? 21.00971  81.04051 -12.34263 1.000 43.01107 ? 228 PRO   A N   1 
ATOM   435  C CA  . PRO   A 1 110 ? 22.24054  81.83780 -12.34796 1.000 54.45020 ? 228 PRO   A CA  1 
ATOM   436  C C   . PRO   A 1 110 ? 23.11237  81.52961 -11.13271 1.000 63.85684 ? 228 PRO   A C   1 
ATOM   437  O O   . PRO   A 1 110 ? 22.77339  80.71839 -10.27496 1.000 61.06490 ? 228 PRO   A O   1 
ATOM   438  C CB  . PRO   A 1 110 ? 21.71506  83.27535 -12.29647 1.000 55.58314 ? 228 PRO   A CB  1 
ATOM   439  C CG  . PRO   A 1 110 ? 20.40891  83.17066 -11.56539 1.000 52.11563 ? 228 PRO   A CG  1 
ATOM   440  C CD  . PRO   A 1 110 ? 19.82268  81.85809 -12.02035 1.000 49.58746 ? 228 PRO   A CD  1 
ATOM   441  N N   . ALA   A 1 111 ? 24.25599  82.20241 -11.07391 1.000 69.93319 ? 229 ALA   A N   1 
ATOM   442  C CA  . ALA   A 1 111 ? 25.12795  82.17137 -9.90901  1.000 71.42396 ? 229 ALA   A CA  1 
ATOM   443  C C   . ALA   A 1 111 ? 24.93449  83.43605 -9.08034  1.000 71.49795 ? 229 ALA   A C   1 
ATOM   444  O O   . ALA   A 1 111 ? 24.36090  84.42937 -9.53668  1.000 68.53273 ? 229 ALA   A O   1 
ATOM   445  C CB  . ALA   A 1 111 ? 26.59489  82.03388 -10.32510 1.000 69.61271 ? 229 ALA   A CB  1 
ATOM   446  N N   . ASP   A 1 112 ? 25.41662  83.39289 -7.84406  1.000 80.48974 ? 230 ASP   A N   1 
ATOM   447  C CA  . ASP   A 1 112 ? 25.32940  84.56863 -6.99171  1.000 82.13589 ? 230 ASP   A CA  1 
ATOM   448  C C   . ASP   A 1 112 ? 26.36985  85.58673 -7.43861  1.000 82.02566 ? 230 ASP   A C   1 
ATOM   449  O O   . ASP   A 1 112 ? 27.57077  85.29323 -7.46332  1.000 82.83625 ? 230 ASP   A O   1 
ATOM   450  C CB  . ASP   A 1 112 ? 25.51507  84.20893 -5.52042  1.000 78.18795 ? 230 ASP   A CB  1 
ATOM   451  C CG  . ASP   A 1 112 ? 24.90651  85.24837 -4.59419  1.000 83.12923 ? 230 ASP   A CG  1 
ATOM   452  O OD1 . ASP   A 1 112 ? 25.13403  86.45971 -4.81320  1.000 81.57442 ? 230 ASP   A OD1 1 
ATOM   453  O OD2 . ASP   A 1 112 ? 24.18265  84.85783 -3.65711  1.000 87.77191 ? 230 ASP   A OD2 1 
ATOM   454  N N   . SER   A 1 113 ? 25.89535  86.77190 -7.81991  1.000 84.45539 ? 231 SER   A N   1 
ATOM   455  C CA  . SER   A 1 113 ? 26.73602  87.91472 -8.14831  1.000 85.93365 ? 231 SER   A CA  1 
ATOM   456  C C   . SER   A 1 113 ? 26.33707  89.11896 -7.30287  1.000 87.32907 ? 231 SER   A C   1 
ATOM   457  O O   . SER   A 1 113 ? 26.40025  90.26319 -7.76626  1.000 86.49941 ? 231 SER   A O   1 
ATOM   458  C CB  . SER   A 1 113 ? 26.65738  88.24490 -9.64006  1.000 77.09433 ? 231 SER   A CB  1 
ATOM   459  N N   . GLY   A 1 114 ? 25.91027  88.86595 -6.06894  1.000 85.91797 ? 232 GLY   A N   1 
ATOM   460  C CA  . GLY   A 1 114 ? 25.49153  89.92023 -5.15622  1.000 86.01525 ? 232 GLY   A CA  1 
ATOM   461  C C   . GLY   A 1 114 ? 24.35575  90.77890 -5.66704  1.000 88.38446 ? 232 GLY   A C   1 
ATOM   462  O O   . GLY   A 1 114 ? 24.39987  92.00748 -5.52203  1.000 89.07180 ? 232 GLY   A O   1 
ATOM   463  N N   . GLY   A 1 115 ? 23.33093  90.16387 -6.25814  1.000 87.06697 ? 233 GLY   A N   1 
ATOM   464  C CA  . GLY   A 1 115 ? 22.23742  90.91586 -6.83568  1.000 80.86291 ? 233 GLY   A CA  1 
ATOM   465  C C   . GLY   A 1 115 ? 20.93644  90.14513 -6.77155  1.000 78.03526 ? 233 GLY   A C   1 
ATOM   466  O O   . GLY   A 1 115 ? 20.88614  89.00556 -6.30399  1.000 76.88300 ? 233 GLY   A O   1 
ATOM   467  N N   . LYS   A 1 116 ? 19.87493  90.78234 -7.27475  1.000 76.42745 ? 234 LYS   A N   1 
ATOM   468  C CA  . LYS   A 1 116 ? 18.52514  90.23428 -7.19514  1.000 73.59032 ? 234 LYS   A CA  1 
ATOM   469  C C   . LYS   A 1 116 ? 18.33659  88.96588 -8.02097  1.000 70.80453 ? 234 LYS   A C   1 
ATOM   470  O O   . LYS   A 1 116 ? 17.28434  88.32870 -7.89946  1.000 67.39319 ? 234 LYS   A O   1 
ATOM   471  C CB  . LYS   A 1 116 ? 17.50567  91.29099 -7.63410  1.000 72.68904 ? 234 LYS   A CB  1 
ATOM   472  N N   . GLU   A 1 117 ? 19.32416  88.58478 -8.84076  1.000 70.35892 ? 235 GLU   A N   1 
ATOM   473  C CA  . GLU   A 1 117 ? 19.21269  87.38127 -9.66295  1.000 69.39311 ? 235 GLU   A CA  1 
ATOM   474  C C   . GLU   A 1 117 ? 18.86339  86.15253 -8.83187  1.000 62.49570 ? 235 GLU   A C   1 
ATOM   475  O O   . GLU   A 1 117 ? 18.26183  85.20157 -9.34592  1.000 59.38353 ? 235 GLU   A O   1 
ATOM   476  C CB  . GLU   A 1 117 ? 20.52875  87.13202 -10.40928 1.000 71.77496 ? 235 GLU   A CB  1 
ATOM   477  C CG  . GLU   A 1 117 ? 21.69315  86.73436 -9.49121  1.000 72.85858 ? 235 GLU   A CG  1 
ATOM   478  C CD  . GLU   A 1 117 ? 22.49369  87.92561 -9.00293  1.000 76.21855 ? 235 GLU   A CD  1 
ATOM   479  O OE1 . GLU   A 1 117 ? 22.08870  89.06647 -9.30189  1.000 71.97192 ? 235 GLU   A OE1 1 
ATOM   480  O OE2 . GLU   A 1 117 ? 23.50439  87.72134 -8.29633  1.000 75.65937 ? 235 GLU   A OE2 1 
ATOM   481  N N   . ILE   A 1 118 ? 19.22944  86.15358 -7.54718  1.000 59.39811 ? 236 ILE   A N   1 
ATOM   482  C CA  . ILE   A 1 118 ? 19.00726  85.00142 -6.68831  1.000 60.22320 ? 236 ILE   A CA  1 
ATOM   483  C C   . ILE   A 1 118 ? 17.52539  84.70681 -6.46708  1.000 51.94080 ? 236 ILE   A C   1 
ATOM   484  O O   . ILE   A 1 118 ? 17.17788  83.59154 -6.06888  1.000 48.18608 ? 236 ILE   A O   1 
ATOM   485  C CB  . ILE   A 1 118 ? 19.74742  85.22717 -5.35553  1.000 63.14784 ? 236 ILE   A CB  1 
ATOM   486  C CG1 . ILE   A 1 118 ? 19.39938  86.60752 -4.79622  1.000 61.17859 ? 236 ILE   A CG1 1 
ATOM   487  C CG2 . ILE   A 1 118 ? 21.24578  85.06700 -5.54542  1.000 73.12811 ? 236 ILE   A CG2 1 
ATOM   488  C CD1 . ILE   A 1 118 ? 19.90707  86.85448 -3.40245  1.000 62.45856 ? 236 ILE   A CD1 1 
ATOM   489  N N   . PHE   A 1 119 ? 16.64448  85.67326 -6.72293  1.000 47.59070 ? 237 PHE   A N   1 
ATOM   490  C CA  . PHE   A 1 119 ? 15.21174  85.51006 -6.52086  1.000 48.00456 ? 237 PHE   A CA  1 
ATOM   491  C C   . PHE   A 1 119 ? 14.44878  85.21469 -7.80438  1.000 42.66511 ? 237 PHE   A C   1 
ATOM   492  O O   . PHE   A 1 119 ? 13.21811  85.32569 -7.81463  1.000 36.19777 ? 237 PHE   A O   1 
ATOM   493  C CB  . PHE   A 1 119 ? 14.62458  86.76235 -5.87240  1.000 49.37345 ? 237 PHE   A CB  1 
ATOM   494  C CG  . PHE   A 1 119 ? 15.27457  87.12795 -4.57318  1.000 50.96651 ? 237 PHE   A CG  1 
ATOM   495  C CD1 . PHE   A 1 119 ? 15.52417  86.15739 -3.61432  1.000 53.57093 ? 237 PHE   A CD1 1 
ATOM   496  C CD2 . PHE   A 1 119 ? 15.63351  88.43694 -4.31028  1.000 54.65965 ? 237 PHE   A CD2 1 
ATOM   497  C CE1 . PHE   A 1 119 ? 16.12413  86.48592 -2.41451  1.000 54.90877 ? 237 PHE   A CE1 1 
ATOM   498  C CE2 . PHE   A 1 119 ? 16.23245  88.77544 -3.11494  1.000 54.54234 ? 237 PHE   A CE2 1 
ATOM   499  C CZ  . PHE   A 1 119 ? 16.47730  87.79895 -2.16482  1.000 57.25852 ? 237 PHE   A CZ  1 
ATOM   500  N N   . SER   A 1 120 ? 15.13846  84.84434 -8.88313  1.000 40.03192 ? 238 SER   A N   1 
ATOM   501  C CA  . SER   A 1 120 ? 14.47073  84.74471 -10.17716 1.000 39.48943 ? 238 SER   A CA  1 
ATOM   502  C C   . SER   A 1 120 ? 13.41086  83.64196 -10.19005 1.000 33.79821 ? 238 SER   A C   1 
ATOM   503  O O   . SER   A 1 120 ? 12.40606  83.76259 -10.89773 1.000 36.65265 ? 238 SER   A O   1 
ATOM   504  C CB  . SER   A 1 120 ? 15.50529  84.51947 -11.29078 1.000 38.78213 ? 238 SER   A CB  1 
ATOM   505  O OG  . SER   A 1 120 ? 16.36370  83.43222 -10.97801 1.000 43.94966 ? 238 SER   A OG  1 
ATOM   506  N N   . LEU   A 1 121 ? 13.60021  82.57817 -9.41060  1.000 30.59027 ? 239 LEU   A N   1 
ATOM   507  C CA  . LEU   A 1 121 ? 12.63490  81.48867 -9.34972  1.000 31.23472 ? 239 LEU   A CA  1 
ATOM   508  C C   . LEU   A 1 121 ? 11.52476  81.67305 -8.32292  1.000 32.23351 ? 239 LEU   A C   1 
ATOM   509  O O   . LEU   A 1 121 ? 10.60580  80.83466 -8.28276  1.000 27.85680 ? 239 LEU   A O   1 
ATOM   510  C CB  . LEU   A 1 121 ? 13.33380  80.15903 -9.04863  1.000 30.27006 ? 239 LEU   A CB  1 
ATOM   511  C CG  . LEU   A 1 121 ? 13.72389  79.33655 -10.26752 1.000 43.74965 ? 239 LEU   A CG  1 
ATOM   512  C CD1 . LEU   A 1 121 ? 14.71385  78.24887 -9.88290  1.000 43.91300 ? 239 LEU   A CD1 1 
ATOM   513  C CD2 . LEU   A 1 121 ? 12.45308  78.73923 -10.88411 1.000 42.27500 ? 239 LEU   A CD2 1 
ATOM   514  N N   . LEU   A 1 122 ? 11.58422  82.72086 -7.49669  1.000 29.12214 ? 240 LEU   A N   1 
ATOM   515  C CA  . LEU   A 1 122 ? 10.60669  82.86510 -6.42086  1.000 30.02759 ? 240 LEU   A CA  1 
ATOM   516  C C   . LEU   A 1 122 ? 9.19066   83.03724 -6.93890  1.000 29.39267 ? 240 LEU   A C   1 
ATOM   517  O O   . LEU   A 1 122 ? 8.28311   82.38197 -6.39746  1.000 29.32506 ? 240 LEU   A O   1 
ATOM   518  C CB  . LEU   A 1 122 ? 11.00131  84.01664 -5.48862  1.000 28.51840 ? 240 LEU   A CB  1 
ATOM   519  C CG  . LEU   A 1 122 ? 12.12143  83.74134 -4.48790  1.000 37.63714 ? 240 LEU   A CG  1 
ATOM   520  C CD1 . LEU   A 1 122 ? 12.24912  84.93101 -3.54425  1.000 38.64041 ? 240 LEU   A CD1 1 
ATOM   521  C CD2 . LEU   A 1 122 ? 11.84567  82.46093 -3.70564  1.000 45.35766 ? 240 LEU   A CD2 1 
ATOM   522  N N   . PRO   A 1 123 ? 8.91584   83.87436 -7.95152  1.000 29.01586 ? 241 PRO   A N   1 
ATOM   523  C CA  . PRO   A 1 123 ? 7.53563   83.94227 -8.45101  1.000 27.72809 ? 241 PRO   A CA  1 
ATOM   524  C C   . PRO   A 1 123 ? 7.01221   82.59764 -8.92035  1.000 30.19089 ? 241 PRO   A C   1 
ATOM   525  O O   . PRO   A 1 123 ? 5.87303   82.24459 -8.59230  1.000 25.85232 ? 241 PRO   A O   1 
ATOM   526  C CB  . PRO   A 1 123 ? 7.62483   84.96196 -9.59422  1.000 28.42704 ? 241 PRO   A CB  1 
ATOM   527  C CG  . PRO   A 1 123 ? 8.79819   85.81656 -9.22756  1.000 30.61113 ? 241 PRO   A CG  1 
ATOM   528  C CD  . PRO   A 1 123 ? 9.77725   84.88976 -8.59790  1.000 29.49985 ? 241 PRO   A CD  1 
ATOM   529  N N   . HIS   A 1 124 ? 7.81438   81.82716 -9.65991  1.000 25.48899 ? 242 HIS   A N   1 
ATOM   530  C CA  . HIS   A 1 124 ? 7.35148   80.51436 -10.09948 1.000 25.52184 ? 242 HIS   A CA  1 
ATOM   531  C C   . HIS   A 1 124 ? 7.06481   79.60029 -8.90955  1.000 26.48715 ? 242 HIS   A C   1 
ATOM   532  O O   . HIS   A 1 124 ? 6.00921   78.95944 -8.84852  1.000 22.66664 ? 242 HIS   A O   1 
ATOM   533  C CB  . HIS   A 1 124 ? 8.36643   79.84652 -11.02218 1.000 23.78095 ? 242 HIS   A CB  1 
ATOM   534  C CG  . HIS   A 1 124 ? 7.96975   78.45341 -11.38839 1.000 25.00427 ? 242 HIS   A CG  1 
ATOM   535  N ND1 . HIS   A 1 124 ? 6.99476   78.18421 -12.32516 1.000 23.76015 ? 242 HIS   A ND1 1 
ATOM   536  C CD2 . HIS   A 1 124 ? 8.35240   77.25437 -10.88520 1.000 24.59058 ? 242 HIS   A CD2 1 
ATOM   537  C CE1 . HIS   A 1 124 ? 6.81786   76.87538 -12.41005 1.000 30.60620 ? 242 HIS   A CE1 1 
ATOM   538  N NE2 . HIS   A 1 124 ? 7.63244   76.28759 -11.54839 1.000 27.23227 ? 242 HIS   A NE2 1 
ATOM   539  N N   . MET   A 1 125 ? 8.01132   79.50931 -7.97226  1.000 24.62182 ? 243 MET   A N   1 
ATOM   540  C CA  . MET   A 1 125 ? 7.82691   78.66024 -6.80189  1.000 27.65393 ? 243 MET   A CA  1 
ATOM   541  C C   . MET   A 1 125 ? 6.64582   79.10189 -5.95389  1.000 25.93965 ? 243 MET   A C   1 
ATOM   542  O O   . MET   A 1 125 ? 5.95943   78.25037 -5.37569  1.000 25.65803 ? 243 MET   A O   1 
ATOM   543  C CB  . MET   A 1 125 ? 9.10604   78.61467 -5.95487  1.000 26.97303 ? 243 MET   A CB  1 
ATOM   544  C CG  . MET   A 1 125 ? 10.22608  77.88285 -6.71783  1.000 32.94740 ? 243 MET   A CG  1 
ATOM   545  S SD  . MET   A 1 125 ? 9.80158   76.18691 -7.26075  1.000 40.10436 ? 243 MET   A SD  1 
ATOM   546  C CE  . MET   A 1 125 ? 8.82167   75.50545 -5.91714  1.000 44.31453 ? 243 MET   A CE  1 
ATOM   547  N N   . ALA   A 1 126 ? 6.40925   80.41288 -5.84506  1.000 24.18376 ? 244 ALA   A N   1 
ATOM   548  C CA  . ALA   A 1 126 ? 5.21468   80.88121 -5.14633  1.000 26.73202 ? 244 ALA   A CA  1 
ATOM   549  C C   . ALA   A 1 126 ? 3.94982   80.36378 -5.82110  1.000 26.11781 ? 244 ALA   A C   1 
ATOM   550  O O   . ALA   A 1 126 ? 3.00728   79.94793 -5.14038  1.000 23.57057 ? 244 ALA   A O   1 
ATOM   551  C CB  . ALA   A 1 126 ? 5.19408   82.40432 -5.05878  1.000 27.53689 ? 244 ALA   A CB  1 
ATOM   552  N N   . ASP   A 1 127 ? 3.91824   80.35530 -7.16159  1.000 23.64967 ? 245 ASP   A N   1 
ATOM   553  C CA  . ASP   A 1 127 ? 2.76193   79.80799 -7.86481  1.000 22.46589 ? 245 ASP   A CA  1 
ATOM   554  C C   . ASP   A 1 127 ? 2.63536   78.29601 -7.66150  1.000 25.60990 ? 245 ASP   A C   1 
ATOM   555  O O   . ASP   A 1 127 ? 1.52284   77.78486 -7.50710  1.000 22.37385 ? 245 ASP   A O   1 
ATOM   556  C CB  . ASP   A 1 127 ? 2.84472   80.13312 -9.35718  1.000 24.44289 ? 245 ASP   A CB  1 
ATOM   557  C CG  . ASP   A 1 127 ? 2.70139   81.62474 -9.63879  1.000 27.50956 ? 245 ASP   A CG  1 
ATOM   558  O OD1 . ASP   A 1 127 ? 2.09065   82.33612 -8.81666  1.000 26.21903 ? 245 ASP   A OD1 1 
ATOM   559  O OD2 . ASP   A 1 127 ? 3.22098   82.08255 -10.67058 1.000 29.34802 ? 245 ASP   A OD2 1 
ATOM   560  N N   . MET   A 1 128 ? 3.75116   77.55725 -7.70883  1.000 22.67145 ? 246 MET   A N   1 
ATOM   561  C CA  . MET   A 1 128 ? 3.70988   76.11484 -7.43079  1.000 22.08692 ? 246 MET   A CA  1 
ATOM   562  C C   . MET   A 1 128 ? 3.24636   75.84355 -5.99804  1.000 21.94360 ? 246 MET   A C   1 
ATOM   563  O O   . MET   A 1 128 ? 2.41109   74.96500 -5.75427  1.000 23.42522 ? 246 MET   A O   1 
ATOM   564  C CB  . MET   A 1 128 ? 5.09583   75.48996 -7.64162  1.000 21.27560 ? 246 MET   A CB  1 
ATOM   565  C CG  . MET   A 1 128 ? 5.21333   73.98760 -7.24882  1.000 26.07134 ? 246 MET   A CG  1 
ATOM   566  S SD  . MET   A 1 128 ? 3.92688   72.89298 -7.88850  1.000 31.10742 ? 246 MET   A SD  1 
ATOM   567  C CE  . MET   A 1 128 ? 4.75902   72.29608 -9.39727  1.000 27.92130 ? 246 MET   A CE  1 
ATOM   568  N N   . SER   A 1 129 ? 3.80714   76.56671 -5.02937  1.000 24.03976 ? 247 SER   A N   1 
ATOM   569  C CA  . SER   A 1 129 ? 3.41637   76.34230 -3.63827  1.000 23.99307 ? 247 SER   A CA  1 
ATOM   570  C C   . SER   A 1 129 ? 1.94296   76.64109 -3.43915  1.000 23.19751 ? 247 SER   A C   1 
ATOM   571  O O   . SER   A 1 129 ? 1.23657   75.88915 -2.76688  1.000 25.31325 ? 247 SER   A O   1 
ATOM   572  C CB  . SER   A 1 129 ? 4.26099   77.20191 -2.70060  1.000 26.16298 ? 247 SER   A CB  1 
ATOM   573  O OG  . SER   A 1 129 ? 5.61976   76.81572 -2.78853  1.000 37.89514 ? 247 SER   A OG  1 
ATOM   574  N N   . THR   A 1 130 ? 1.46212   77.72546 -4.04698  1.000 24.39885 ? 248 THR   A N   1 
ATOM   575  C CA  . THR   A 1 130 ? 0.05864   78.10106 -3.92845  1.000 26.69905 ? 248 THR   A CA  1 
ATOM   576  C C   . THR   A 1 130 ? -0.84592  77.01809 -4.48363  1.000 25.17933 ? 248 THR   A C   1 
ATOM   577  O O   . THR   A 1 130 ? -1.86367  76.67320 -3.87079  1.000 25.02962 ? 248 THR   A O   1 
ATOM   578  C CB  . THR   A 1 130 ? -0.17535  79.42547 -4.65008  1.000 25.59383 ? 248 THR   A CB  1 
ATOM   579  O OG1 . THR   A 1 130 ? 0.64638   80.43104 -4.03182  1.000 25.81984 ? 248 THR   A OG1 1 
ATOM   580  C CG2 . THR   A 1 130 ? -1.65476  79.80360 -4.59617  1.000 30.07370 ? 248 THR   A CG2 1 
ATOM   581  N N   . TYR   A 1 131 ? -0.49207  76.47970 -5.66056  1.000 25.95810 ? 249 TYR   A N   1 
ATOM   582  C CA  . TYR   A 1 131 ? -1.21373  75.34832 -6.22966  1.000 26.44516 ? 249 TYR   A CA  1 
ATOM   583  C C   . TYR   A 1 131 ? -1.24072  74.17083 -5.25713  1.000 26.55982 ? 249 TYR   A C   1 
ATOM   584  O O   . TYR   A 1 131 ? -2.28471  73.53519 -5.05426  1.000 23.33850 ? 249 TYR   A O   1 
ATOM   585  C CB  . TYR   A 1 131 ? -0.57314  74.92987 -7.56079  1.000 26.25416 ? 249 TYR   A CB  1 
ATOM   586  C CG  . TYR   A 1 131 ? -1.32273  73.83040 -8.23411  1.000 25.06600 ? 249 TYR   A CG  1 
ATOM   587  C CD1 . TYR   A 1 131 ? -2.55399  74.08611 -8.82026  1.000 30.95170 ? 249 TYR   A CD1 1 
ATOM   588  C CD2 . TYR   A 1 131 ? -0.83685  72.52532 -8.25349  1.000 28.56373 ? 249 TYR   A CD2 1 
ATOM   589  C CE1 . TYR   A 1 131 ? -3.27533  73.09596 -9.41862  1.000 33.56923 ? 249 TYR   A CE1 1 
ATOM   590  C CE2 . TYR   A 1 131 ? -1.56812  71.50943 -8.87935  1.000 30.18780 ? 249 TYR   A CE2 1 
ATOM   591  C CZ  . TYR   A 1 131 ? -2.78712  71.81783 -9.45205  1.000 33.80754 ? 249 TYR   A CZ  1 
ATOM   592  O OH  . TYR   A 1 131 ? -3.55113  70.85925 -10.07282 1.000 39.25768 ? 249 TYR   A OH  1 
ATOM   593  N N   . MET   A 1 132 ? -0.09176  73.85886 -4.65020  1.000 24.76149 ? 250 MET   A N   1 
ATOM   594  C CA  . MET   A 1 132 ? -0.04566  72.74981 -3.69920  1.000 25.68377 ? 250 MET   A CA  1 
ATOM   595  C C   . MET   A 1 132 ? -0.89079  73.04534 -2.46259  1.000 27.44099 ? 250 MET   A C   1 
ATOM   596  O O   . MET   A 1 132 ? -1.60159  72.16162 -1.96383  1.000 24.45420 ? 250 MET   A O   1 
ATOM   597  C CB  . MET   A 1 132 ? 1.39924   72.43951 -3.28686  1.000 20.54697 ? 250 MET   A CB  1 
ATOM   598  C CG  . MET   A 1 132 ? 2.24947   71.91882 -4.47143  1.000 26.16908 ? 250 MET   A CG  1 
ATOM   599  S SD  . MET   A 1 132 ? 1.76359   70.24715 -4.95150  1.000 26.83234 ? 250 MET   A SD  1 
ATOM   600  C CE  . MET   A 1 132 ? 2.24927   69.28662 -3.51440  1.000 27.86852 ? 250 MET   A CE  1 
ATOM   601  N N   . PHE   A 1 133 ? -0.80077  74.27271 -1.93781  1.000 22.99988 ? 251 PHE   A N   1 
ATOM   602  C CA  . PHE   A 1 133 ? -1.56030  74.62912 -0.73954  1.000 27.30167 ? 251 PHE   A CA  1 
ATOM   603  C C   . PHE   A 1 133 ? -3.06486  74.52652 -0.98549  1.000 24.84751 ? 251 PHE   A C   1 
ATOM   604  O O   . PHE   A 1 133 ? -3.80483  74.07666 -0.10641  1.000 23.70379 ? 251 PHE   A O   1 
ATOM   605  C CB  . PHE   A 1 133 ? -1.18703  76.03935 -0.27473  1.000 24.31185 ? 251 PHE   A CB  1 
ATOM   606  C CG  . PHE   A 1 133 ? 0.21799   76.15798 0.28263   1.000 25.52421 ? 251 PHE   A CG  1 
ATOM   607  C CD1 . PHE   A 1 133 ? 0.76798   75.14358 1.04975   1.000 24.80601 ? 251 PHE   A CD1 1 
ATOM   608  C CD2 . PHE   A 1 133 ? 0.99134   77.28583 0.02236   1.000 26.17640 ? 251 PHE   A CD2 1 
ATOM   609  C CE1 . PHE   A 1 133 ? 2.06988   75.24781 1.55125   1.000 26.31766 ? 251 PHE   A CE1 1 
ATOM   610  C CE2 . PHE   A 1 133 ? 2.28228   77.40570 0.53534   1.000 29.63548 ? 251 PHE   A CE2 1 
ATOM   611  C CZ  . PHE   A 1 133 ? 2.82365   76.38769 1.29400   1.000 30.79970 ? 251 PHE   A CZ  1 
ATOM   612  N N   . LYS   A 1 134 ? -3.53667  74.95392 -2.16392  1.000 23.81757 ? 252 LYS   A N   1 
ATOM   613  C CA  . LYS   A 1 134 ? -4.94542  74.75230 -2.50972  1.000 29.11656 ? 252 LYS   A CA  1 
ATOM   614  C C   . LYS   A 1 134 ? -5.32384  73.28503 -2.41070  1.000 30.29566 ? 252 LYS   A C   1 
ATOM   615  O O   . LYS   A 1 134 ? -6.38873  72.95089 -1.87839  1.000 25.29849 ? 252 LYS   A O   1 
ATOM   616  C CB  . LYS   A 1 134 ? -5.25197  75.25521 -3.91194  1.000 24.12857 ? 252 LYS   A CB  1 
ATOM   617  C CG  . LYS   A 1 134 ? -5.09592  76.74473 -4.00734  1.000 32.65091 ? 252 LYS   A CG  1 
ATOM   618  C CD  . LYS   A 1 134 ? -5.47968  77.28360 -5.37778  1.000 35.32917 ? 252 LYS   A CD  1 
ATOM   619  C CE  . LYS   A 1 134 ? -5.27296  78.77647 -5.31592  1.000 46.29020 ? 252 LYS   A CE  1 
ATOM   620  N NZ  . LYS   A 1 134 ? -5.45433  79.54591 -6.57939  1.000 48.80526 ? 252 LYS   A NZ  1 
ATOM   621  N N   . GLY   A 1 135 ? -4.47824  72.39351 -2.93947  1.000 26.15787 ? 253 GLY   A N   1 
ATOM   622  C CA  . GLY   A 1 135 ? -4.74908  70.96576 -2.80007  1.000 26.89533 ? 253 GLY   A CA  1 
ATOM   623  C C   . GLY   A 1 135 ? -4.80298  70.52247 -1.34849  1.000 26.08782 ? 253 GLY   A C   1 
ATOM   624  O O   . GLY   A 1 135 ? -5.68159  69.74995 -0.96258  1.000 24.31088 ? 253 GLY   A O   1 
ATOM   625  N N   . ILE   A 1 136 ? -3.86426  71.01628 -0.52792  1.000 22.57623 ? 254 ILE   A N   1 
ATOM   626  C CA  . ILE   A 1 136 ? -3.79718  70.64650 0.87938   1.000 24.77277 ? 254 ILE   A CA  1 
ATOM   627  C C   . ILE   A 1 136 ? -5.04465  71.12369 1.60203   1.000 27.76454 ? 254 ILE   A C   1 
ATOM   628  O O   . ILE   A 1 136 ? -5.61605  70.40462 2.43461   1.000 25.05275 ? 254 ILE   A O   1 
ATOM   629  C CB  . ILE   A 1 136 ? -2.51521  71.22513 1.52515   1.000 26.28908 ? 254 ILE   A CB  1 
ATOM   630  C CG1 . ILE   A 1 136 ? -1.25641  70.58725 0.93038   1.000 30.50719 ? 254 ILE   A CG1 1 
ATOM   631  C CG2 . ILE   A 1 136 ? -2.56743  71.13565 3.03571   1.000 34.18329 ? 254 ILE   A CG2 1 
ATOM   632  C CD1 . ILE   A 1 136 ? -1.26308  69.13128 1.05492   1.000 25.07786 ? 254 ILE   A CD1 1 
ATOM   633  N N   . ILE   A 1 137 ? -5.49623  72.33971 1.28312   1.000 23.90354 ? 255 ILE   A N   1 
ATOM   634  C CA  . ILE   A 1 137 ? -6.71052  72.85015 1.91289   1.000 27.84412 ? 255 ILE   A CA  1 
ATOM   635  C C   . ILE   A 1 137 ? -7.91587  71.99698 1.51960   1.000 28.83621 ? 255 ILE   A C   1 
ATOM   636  O O   . ILE   A 1 137 ? -8.74166  71.63866 2.37315   1.000 27.26200 ? 255 ILE   A O   1 
ATOM   637  C CB  . ILE   A 1 137 ? -6.91169  74.34078 1.57339   1.000 27.08651 ? 255 ILE   A CB  1 
ATOM   638  C CG1 . ILE   A 1 137 ? -5.80496  75.18692 2.22531   1.000 25.88903 ? 255 ILE   A CG1 1 
ATOM   639  C CG2 . ILE   A 1 137 ? -8.32281  74.83249 2.02550   1.000 27.21521 ? 255 ILE   A CG2 1 
ATOM   640  C CD1 . ILE   A 1 137 ? -5.69334  76.61856 1.62829   1.000 26.67170 ? 255 ILE   A CD1 1 
ATOM   641  N N   . SER   A 1 138 ? -8.02376  71.63740 0.23320   1.000 23.32349 ? 256 SER   A N   1 
ATOM   642  C CA  . SER   A 1 138 ? -9.12117  70.77689 -0.21184  1.000 28.29873 ? 256 SER   A CA  1 
ATOM   643  C C   . SER   A 1 138 ? -9.09715  69.42492 0.49440   1.000 28.08738 ? 256 SER   A C   1 
ATOM   644  O O   . SER   A 1 138 ? -10.14716 68.90683 0.89273   1.000 26.86519 ? 256 SER   A O   1 
ATOM   645  C CB  . SER   A 1 138 ? -9.06184  70.57838 -1.72429  1.000 27.19488 ? 256 SER   A CB  1 
ATOM   646  O OG  . SER   A 1 138 ? -9.17308  71.81689 -2.38681  1.000 33.69505 ? 256 SER   A OG  1 
ATOM   647  N N   . PHE   A 1 139 ? -7.90798  68.82776 0.62484   1.000 22.52979 ? 257 PHE   A N   1 
ATOM   648  C CA  . PHE   A 1 139 ? -7.72903  67.57856 1.35683   1.000 21.95610 ? 257 PHE   A CA  1 
ATOM   649  C C   . PHE   A 1 139 ? -8.34145  67.64513 2.75567   1.000 24.40136 ? 257 PHE   A C   1 
ATOM   650  O O   . PHE   A 1 139 ? -9.17265  66.80436 3.12635   1.000 24.52154 ? 257 PHE   A O   1 
ATOM   651  C CB  . PHE   A 1 139 ? -6.22796  67.27169 1.44652   1.000 20.71383 ? 257 PHE   A CB  1 
ATOM   652  C CG  . PHE   A 1 139 ? -5.87557  66.12627 2.34777   1.000 21.00403 ? 257 PHE   A CG  1 
ATOM   653  C CD1 . PHE   A 1 139 ? -6.07088  64.80638 1.93669   1.000 23.47428 ? 257 PHE   A CD1 1 
ATOM   654  C CD2 . PHE   A 1 139 ? -5.31663  66.36653 3.60046   1.000 23.75449 ? 257 PHE   A CD2 1 
ATOM   655  C CE1 . PHE   A 1 139 ? -5.72171  63.74601 2.75189   1.000 23.29944 ? 257 PHE   A CE1 1 
ATOM   656  C CE2 . PHE   A 1 139 ? -4.96580  65.32479 4.43152   1.000 21.58415 ? 257 PHE   A CE2 1 
ATOM   657  C CZ  . PHE   A 1 139 ? -5.17460  63.99737 4.01591   1.000 24.59913 ? 257 PHE   A CZ  1 
ATOM   658  N N   . ALA   A 1 140 ? -7.89569  68.62021 3.55800   1.000 24.02820 ? 258 ALA   A N   1 
ATOM   659  C CA  . ALA   A 1 140 ? -8.41788  68.80539 4.90872   1.000 28.09041 ? 258 ALA   A CA  1 
ATOM   660  C C   . ALA   A 1 140 ? -9.93604  68.93890 4.89509   1.000 29.61951 ? 258 ALA   A C   1 
ATOM   661  O O   . ALA   A 1 140 ? -10.63171 68.28154 5.67183   1.000 26.06452 ? 258 ALA   A O   1 
ATOM   662  C CB  . ALA   A 1 140 ? -7.78207  70.03822 5.56524   1.000 26.33353 ? 258 ALA   A CB  1 
ATOM   663  N N   . LYS   A 1 141 ? -10.47276 69.75006 3.97653   1.000 29.57100 ? 259 LYS   A N   1 
ATOM   664  C CA  . LYS   A 1 141 ? -11.90596 70.04427 3.99260   1.000 30.38516 ? 259 LYS   A CA  1 
ATOM   665  C C   . LYS   A 1 141 ? -12.77522 68.83503 3.63443   1.000 37.21008 ? 259 LYS   A C   1 
ATOM   666  O O   . LYS   A 1 141 ? -13.94937 68.79573 4.02398   1.000 39.50239 ? 259 LYS   A O   1 
ATOM   667  C CB  . LYS   A 1 141 ? -12.18938 71.23102 3.06517   1.000 32.60234 ? 259 LYS   A CB  1 
ATOM   668  C CG  . LYS   A 1 141 ? -11.88481 72.57841 3.72628   1.000 37.48227 ? 259 LYS   A CG  1 
ATOM   669  C CD  . LYS   A 1 141 ? -12.05828 73.75111 2.75043   1.000 42.76915 ? 259 LYS   A CD  1 
ATOM   670  N N   . VAL   A 1 142 ? -12.22383 67.83966 2.93507   1.000 29.53370 ? 260 VAL   A N   1 
ATOM   671  C CA  . VAL   A 1 142 ? -12.94304 66.60411 2.63690   1.000 33.35243 ? 260 VAL   A CA  1 
ATOM   672  C C   . VAL   A 1 142 ? -13.07510 65.68637 3.85033   1.000 34.55463 ? 260 VAL   A C   1 
ATOM   673  O O   . VAL   A 1 142 ? -13.98621 64.85013 3.88763   1.000 37.15514 ? 260 VAL   A O   1 
ATOM   674  C CB  . VAL   A 1 142 ? -12.24936 65.86374 1.46461   1.000 35.79872 ? 260 VAL   A CB  1 
ATOM   675  C CG1 . VAL   A 1 142 ? -12.61884 64.36800 1.41722   1.000 44.82734 ? 260 VAL   A CG1 1 
ATOM   676  C CG2 . VAL   A 1 142 ? -12.62314 66.50527 0.16882   1.000 45.08596 ? 260 VAL   A CG2 1 
ATOM   677  N N   . ILE   A 1 143 ? -12.21068 65.82020 4.85476   1.000 31.85010 ? 261 ILE   A N   1 
ATOM   678  C CA  . ILE   A 1 143 ? -12.13279 64.84970 5.93926   1.000 31.40608 ? 261 ILE   A CA  1 
ATOM   679  C C   . ILE   A 1 143 ? -13.15010 65.19137 7.03141   1.000 35.85482 ? 261 ILE   A C   1 
ATOM   680  O O   . ILE   A 1 143 ? -13.16107 66.30393 7.56813   1.000 29.77767 ? 261 ILE   A O   1 
ATOM   681  C CB  . ILE   A 1 143 ? -10.70859 64.78197 6.51394   1.000 31.47365 ? 261 ILE   A CB  1 
ATOM   682  C CG1 . ILE   A 1 143 ? -9.70670  64.39462 5.41532   1.000 30.97296 ? 261 ILE   A CG1 1 
ATOM   683  C CG2 . ILE   A 1 143 ? -10.63856 63.80149 7.67064   1.000 30.71372 ? 261 ILE   A CG2 1 
ATOM   684  C CD1 . ILE   A 1 143 ? -8.26980  64.70325 5.80671   1.000 27.16747 ? 261 ILE   A CD1 1 
ATOM   685  N N   . SER   A 1 144 ? -13.97510 64.20365 7.38417   1.000 34.88176 ? 262 SER   A N   1 
ATOM   686  C CA  . SER   A 1 144 ? -15.03491 64.38635 8.37592   1.000 36.52621 ? 262 SER   A CA  1 
ATOM   687  C C   . SER   A 1 144 ? -14.50005 64.94572 9.69112   1.000 35.51036 ? 262 SER   A C   1 
ATOM   688  O O   . SER   A 1 144 ? -15.02704 65.93343 10.21757  1.000 33.92477 ? 262 SER   A O   1 
ATOM   689  C CB  . SER   A 1 144 ? -15.72624 63.04945 8.61500   1.000 34.90043 ? 262 SER   A CB  1 
ATOM   690  O OG  . SER   A 1 144 ? -14.78488 62.10549 9.10657   1.000 39.87402 ? 262 SER   A OG  1 
ATOM   691  N N   . TYR   A 1 145 ? -13.44623 64.32450 10.23290  1.000 32.09408 ? 263 TYR   A N   1 
ATOM   692  C CA  . TYR   A 1 145 ? -12.89046 64.76674 11.51024  1.000 35.22082 ? 263 TYR   A CA  1 
ATOM   693  C C   . TYR   A 1 145 ? -12.46882 66.22752 11.48031  1.000 37.37158 ? 263 TYR   A C   1 
ATOM   694  O O   . TYR   A 1 145 ? -12.51259 66.90150 12.51897  1.000 33.61214 ? 263 TYR   A O   1 
ATOM   695  C CB  . TYR   A 1 145 ? -11.69335 63.89951 11.91000  1.000 36.57389 ? 263 TYR   A CB  1 
ATOM   696  C CG  . TYR   A 1 145 ? -11.88882 62.42522 11.68132  1.000 41.74535 ? 263 TYR   A CG  1 
ATOM   697  C CD1 . TYR   A 1 145 ? -12.48216 61.61706 12.65204  1.000 43.91803 ? 263 TYR   A CD1 1 
ATOM   698  C CD2 . TYR   A 1 145 ? -11.48610 61.83553 10.49470  1.000 44.68927 ? 263 TYR   A CD2 1 
ATOM   699  C CE1 . TYR   A 1 145 ? -12.66251 60.25476 12.43729  1.000 45.15965 ? 263 TYR   A CE1 1 
ATOM   700  C CE2 . TYR   A 1 145 ? -11.66510 60.48549 10.26942  1.000 46.93375 ? 263 TYR   A CE2 1 
ATOM   701  C CZ  . TYR   A 1 145 ? -12.24778 59.69777 11.24288  1.000 49.07286 ? 263 TYR   A CZ  1 
ATOM   702  O OH  . TYR   A 1 145 ? -12.41570 58.34738 10.99995  1.000 52.59033 ? 263 TYR   A OH  1 
ATOM   703  N N   . PHE   A 1 146 ? -12.03861 66.73061 10.31285  1.000 30.53856 ? 264 PHE   A N   1 
ATOM   704  C CA  . PHE   A 1 146 ? -11.62719 68.12776 10.18911  1.000 32.40409 ? 264 PHE   A CA  1 
ATOM   705  C C   . PHE   A 1 146 ? -12.84090 69.03513 10.00926  1.000 33.95693 ? 264 PHE   A C   1 
ATOM   706  O O   . PHE   A 1 146 ? -12.91785 70.11632 10.60677  1.000 31.21731 ? 264 PHE   A O   1 
ATOM   707  C CB  . PHE   A 1 146 ? -10.66785 68.27495 8.99769   1.000 28.04013 ? 264 PHE   A CB  1 
ATOM   708  C CG  . PHE   A 1 146 ? -10.09371 69.65765 8.81999   1.000 29.50780 ? 264 PHE   A CG  1 
ATOM   709  C CD1 . PHE   A 1 146 ? -8.94328  70.03125 9.48504   1.000 33.83975 ? 264 PHE   A CD1 1 
ATOM   710  C CD2 . PHE   A 1 146 ? -10.69587 70.57249 7.96882   1.000 29.92101 ? 264 PHE   A CD2 1 
ATOM   711  C CE1 . PHE   A 1 146 ? -8.40484  71.29445 9.30801   1.000 30.30401 ? 264 PHE   A CE1 1 
ATOM   712  C CE2 . PHE   A 1 146 ? -10.16940 71.82834 7.78607   1.000 28.95513 ? 264 PHE   A CE2 1 
ATOM   713  C CZ  . PHE   A 1 146 ? -9.01992  72.19192 8.46231   1.000 28.52017 ? 264 PHE   A CZ  1 
ATOM   714  N N   . ARG   A 1 147 ? -13.78611 68.60305 9.17402   1.000 32.30418 ? 265 ARG   A N   1 
ATOM   715  C CA  . ARG   A 1 147 ? -15.00131 69.37071 8.92364   1.000 36.20877 ? 265 ARG   A CA  1 
ATOM   716  C C   . ARG   A 1 147 ? -15.79230 69.60339 10.20282  1.000 39.13891 ? 265 ARG   A C   1 
ATOM   717  O O   . ARG   A 1 147 ? -16.47658 70.62568 10.33648  1.000 42.07873 ? 265 ARG   A O   1 
ATOM   718  C CB  . ARG   A 1 147 ? -15.87066 68.62437 7.91369   1.000 37.09656 ? 265 ARG   A CB  1 
ATOM   719  C CG  . ARG   A 1 147 ? -15.87056 69.20400 6.52486   1.000 48.14321 ? 265 ARG   A CG  1 
ATOM   720  C CD  . ARG   A 1 147 ? -16.99312 68.58070 5.72405   1.000 47.15752 ? 265 ARG   A CD  1 
ATOM   721  N NE  . ARG   A 1 147 ? -16.70731 67.18427 5.40672   1.000 52.63776 ? 265 ARG   A NE  1 
ATOM   722  C CZ  . ARG   A 1 147 ? -17.45425 66.15988 5.81030   1.000 54.71081 ? 265 ARG   A CZ  1 
ATOM   723  N NH1 . ARG   A 1 147 ? -18.52034 66.37684 6.56775   1.000 62.55443 ? 265 ARG   A NH1 1 
ATOM   724  N NH2 . ARG   A 1 147 ? -17.12643 64.91683 5.47498   1.000 51.42103 ? 265 ARG   A NH2 1 
ATOM   725  N N   . ASP   A 1 148 ? -15.72552 68.65657 11.13682  1.000 38.13026 ? 266 ASP   A N   1 
ATOM   726  C CA  . ASP   A 1 148 ? -16.46676 68.74872 12.39021  1.000 43.32674 ? 266 ASP   A CA  1 
ATOM   727  C C   . ASP   A 1 148 ? -15.87060 69.76473 13.34874  1.000 47.70864 ? 266 ASP   A C   1 
ATOM   728  O O   . ASP   A 1 148 ? -16.54202 70.15511 14.31027  1.000 44.29127 ? 266 ASP   A O   1 
ATOM   729  C CB  . ASP   A 1 148 ? -16.51469 67.37870 13.07097  1.000 39.54100 ? 266 ASP   A CB  1 
ATOM   730  C CG  . ASP   A 1 148 ? -17.40933 66.38857 12.34329  1.000 40.83561 ? 266 ASP   A CG  1 
ATOM   731  O OD1 . ASP   A 1 148 ? -18.21987 66.82479 11.50496  1.000 41.68189 ? 266 ASP   A OD1 1 
ATOM   732  O OD2 . ASP   A 1 148 ? -17.28263 65.16874 12.60083  1.000 45.95726 ? 266 ASP   A OD2 1 
ATOM   733  N N   . LEU   A 1 149 ? -14.62645 70.18696 13.12498  1.000 41.52708 ? 267 LEU   A N   1 
ATOM   734  C CA  . LEU   A 1 149 ? -13.98984 71.12762 14.02951  1.000 35.34177 ? 267 LEU   A CA  1 
ATOM   735  C C   . LEU   A 1 149 ? -14.53751 72.53680 13.80951  1.000 36.99548 ? 267 LEU   A C   1 
ATOM   736  O O   . LEU   A 1 149 ? -15.01815 72.85564 12.71832  1.000 35.82579 ? 267 LEU   A O   1 
ATOM   737  C CB  . LEU   A 1 149 ? -12.47685 71.11964 13.81899  1.000 38.07932 ? 267 LEU   A CB  1 
ATOM   738  C CG  . LEU   A 1 149 ? -11.73248 69.82160 14.14917  1.000 39.84613 ? 267 LEU   A CG  1 
ATOM   739  C CD1 . LEU   A 1 149 ? -10.29071 69.89854 13.67038  1.000 35.33828 ? 267 LEU   A CD1 1 
ATOM   740  C CD2 . LEU   A 1 149 ? -11.76213 69.56031 15.63850  1.000 38.63470 ? 267 LEU   A CD2 1 
ATOM   741  N N   . PRO   A 1 150 ? -14.48729 73.39177 14.83749  1.000 35.33391 ? 268 PRO   A N   1 
ATOM   742  C CA  . PRO   A 1 150 ? -14.84112 74.80674 14.64372  1.000 43.11443 ? 268 PRO   A CA  1 
ATOM   743  C C   . PRO   A 1 150 ? -13.97214 75.44255 13.56721  1.000 39.45299 ? 268 PRO   A C   1 
ATOM   744  O O   . PRO   A 1 150 ? -12.78307 75.14619 13.46265  1.000 38.72742 ? 268 PRO   A O   1 
ATOM   745  C CB  . PRO   A 1 150 ? -14.55922 75.43396 16.01438  1.000 43.39579 ? 268 PRO   A CB  1 
ATOM   746  C CG  . PRO   A 1 150 ? -14.60456 74.29991 16.97598  1.000 49.03971 ? 268 PRO   A CG  1 
ATOM   747  C CD  . PRO   A 1 150 ? -14.05926 73.11622 16.21933  1.000 44.77861 ? 268 PRO   A CD  1 
ATOM   748  N N   . ILE   A 1 151 ? -14.56648 76.36309 12.80231  1.000 39.73709 ? 269 ILE   A N   1 
ATOM   749  C CA  . ILE   A 1 151 ? -13.89010 76.92572 11.63290  1.000 45.25743 ? 269 ILE   A CA  1 
ATOM   750  C C   . ILE   A 1 151 ? -12.58072 77.60487 12.02333  1.000 48.09951 ? 269 ILE   A C   1 
ATOM   751  O O   . ILE   A 1 151 ? -11.58675 77.53310 11.28697  1.000 38.73871 ? 269 ILE   A O   1 
ATOM   752  C CB  . ILE   A 1 151 ? -14.82856 77.88389 10.87529  1.000 46.85787 ? 269 ILE   A CB  1 
ATOM   753  C CG1 . ILE   A 1 151 ? -14.16102 78.37240 9.59029   1.000 52.22709 ? 269 ILE   A CG1 1 
ATOM   754  C CG2 . ILE   A 1 151 ? -15.22512 79.06563 11.74586  1.000 53.61803 ? 269 ILE   A CG2 1 
ATOM   755  C CD1 . ILE   A 1 151 ? -13.76365 77.24947 8.64138   1.000 51.07724 ? 269 ILE   A CD1 1 
ATOM   756  N N   . GLU   A 1 152 ? -12.54547 78.25307 13.19000  1.000 41.16708 ? 270 GLU   A N   1 
ATOM   757  C CA  . GLU   A 1 152 ? -11.31975 78.92493 13.61167  1.000 47.56660 ? 270 GLU   A CA  1 
ATOM   758  C C   . GLU   A 1 152 ? -10.20747 77.92823 13.89347  1.000 39.89075 ? 270 GLU   A C   1 
ATOM   759  O O   . GLU   A 1 152 ? -9.03159  78.24283 13.68700  1.000 40.10282 ? 270 GLU   A O   1 
ATOM   760  C CB  . GLU   A 1 152 ? -11.57129 79.78270 14.85695  1.000 49.91878 ? 270 GLU   A CB  1 
ATOM   761  C CG  . GLU   A 1 152 ? -12.66218 80.81758 14.69071  1.000 51.86151 ? 270 GLU   A CG  1 
ATOM   762  C CD  . GLU   A 1 152 ? -14.06030 80.26613 14.95495  1.000 58.89124 ? 270 GLU   A CD  1 
ATOM   763  O OE1 . GLU   A 1 152 ? -14.19479 79.17595 15.56185  1.000 53.30444 ? 270 GLU   A OE1 1 
ATOM   764  O OE2 . GLU   A 1 152 ? -15.03196 80.93439 14.54639  1.000 66.82327 ? 270 GLU   A OE2 1 
ATOM   765  N N   . ASP   A 1 153 ? -10.55397 76.73768 14.38213  1.000 36.36915 ? 271 ASP   A N   1 
ATOM   766  C CA  . ASP   A 1 153 ? -9.54274  75.70506 14.57905  1.000 38.92446 ? 271 ASP   A CA  1 
ATOM   767  C C   . ASP   A 1 153 ? -9.11157  75.08801 13.24891  1.000 36.91213 ? 271 ASP   A C   1 
ATOM   768  O O   . ASP   A 1 153 ? -7.92794  74.78809 13.06430  1.000 36.13196 ? 271 ASP   A O   1 
ATOM   769  C CB  . ASP   A 1 153 ? -10.06315 74.62643 15.52325  1.000 39.47370 ? 271 ASP   A CB  1 
ATOM   770  C CG  . ASP   A 1 153 ? -9.98649  75.04511 16.99596  1.000 48.79230 ? 271 ASP   A CG  1 
ATOM   771  O OD1 . ASP   A 1 153 ? -9.65467  76.21530 17.28828  1.000 48.74095 ? 271 ASP   A OD1 1 
ATOM   772  O OD2 . ASP   A 1 153 ? -10.24019 74.18778 17.86132  1.000 46.56435 ? 271 ASP   A OD2 1 
ATOM   773  N N   . GLN   A 1 154 ? -10.05903 74.87632 12.32967  1.000 33.89662 ? 272 GLN   A N   1 
ATOM   774  C CA  . GLN   A 1 154 ? -9.71436  74.47725 10.96469  1.000 37.55072 ? 272 GLN   A CA  1 
ATOM   775  C C   . GLN   A 1 154 ? -8.65631  75.39918 10.38003  1.000 37.35579 ? 272 GLN   A C   1 
ATOM   776  O O   . GLN   A 1 154 ? -7.65210  74.94392 9.81811   1.000 29.63071 ? 272 GLN   A O   1 
ATOM   777  C CB  . GLN   A 1 154 ? -10.95675 74.49660 10.07228  1.000 33.96439 ? 272 GLN   A CB  1 
ATOM   778  C CG  . GLN   A 1 154 ? -12.04021 73.53522 10.47747  1.000 35.11185 ? 272 GLN   A CG  1 
ATOM   779  C CD  . GLN   A 1 154 ? -13.17307 73.51278 9.49057   1.000 40.47687 ? 272 GLN   A CD  1 
ATOM   780  O OE1 . GLN   A 1 154 ? -13.01694 73.92452 8.35140   1.000 42.04318 ? 272 GLN   A OE1 1 
ATOM   781  N NE2 . GLN   A 1 154 ? -14.33757 73.04922 9.93215   1.000 39.36127 ? 272 GLN   A NE2 1 
ATOM   782  N N   . ILE   A 1 155 ? -8.87843  76.70929 10.49542  1.000 36.25924 ? 273 ILE   A N   1 
ATOM   783  C CA  . ILE   A 1 155 ? -7.93565  77.67434 9.94395   1.000 39.07756 ? 273 ILE   A CA  1 
ATOM   784  C C   . ILE   A 1 155 ? -6.60998  77.60760 10.69147  1.000 39.45863 ? 273 ILE   A C   1 
ATOM   785  O O   . ILE   A 1 155 ? -5.53504  77.60253 10.07888  1.000 33.47533 ? 273 ILE   A O   1 
ATOM   786  C CB  . ILE   A 1 155 ? -8.55240  79.08659 9.97632   1.000 39.99424 ? 273 ILE   A CB  1 
ATOM   787  C CG1 . ILE   A 1 155 ? -9.63159  79.20153 8.91214   1.000 40.59566 ? 273 ILE   A CG1 1 
ATOM   788  C CG2 . ILE   A 1 155 ? -7.49507  80.15650 9.74411   1.000 39.20224 ? 273 ILE   A CG2 1 
ATOM   789  C CD1 . ILE   A 1 155 ? -10.79155 80.05602 9.31679   1.000 51.41216 ? 273 ILE   A CD1 1 
ATOM   790  N N   . SER   A 1 156 ? -6.65860  77.52366 12.02308  1.000 31.90903 ? 274 SER   A N   1 
ATOM   791  C CA  . SER   A 1 156 ? -5.42355  77.43708 12.79168  1.000 34.17854 ? 274 SER   A CA  1 
ATOM   792  C C   . SER   A 1 156 ? -4.62627  76.18516 12.43257  1.000 34.09720 ? 274 SER   A C   1 
ATOM   793  O O   . SER   A 1 156 ? -3.39150  76.23120 12.34240  1.000 31.85295 ? 274 SER   A O   1 
ATOM   794  C CB  . SER   A 1 156 ? -5.73956  77.47631 14.28572  1.000 39.87123 ? 274 SER   A CB  1 
ATOM   795  O OG  . SER   A 1 156 ? -6.10140  78.79389 14.66297  1.000 40.92676 ? 274 SER   A OG  1 
ATOM   796  N N   . LEU   A 1 157 ? -5.30972  75.05595 12.22627  1.000 28.78378 ? 275 LEU   A N   1 
ATOM   797  C CA  . LEU   A 1 157 ? -4.60278  73.81952 11.90589  1.000 27.79799 ? 275 LEU   A CA  1 
ATOM   798  C C   . LEU   A 1 157 ? -3.96905  73.88566 10.51468  1.000 31.04865 ? 275 LEU   A C   1 
ATOM   799  O O   . LEU   A 1 157 ? -2.83720  73.41346 10.31684  1.000 27.84345 ? 275 LEU   A O   1 
ATOM   800  C CB  . LEU   A 1 157 ? -5.55674  72.63161 12.00970  1.000 27.80815 ? 275 LEU   A CB  1 
ATOM   801  C CG  . LEU   A 1 157 ? -6.00362  72.24866 13.42693  1.000 28.19255 ? 275 LEU   A CG  1 
ATOM   802  C CD1 . LEU   A 1 157 ? -6.97124  71.09139 13.36349  1.000 33.16164 ? 275 LEU   A CD1 1 
ATOM   803  C CD2 . LEU   A 1 157 ? -4.83244  71.92651 14.33699  1.000 25.93691 ? 275 LEU   A CD2 1 
ATOM   804  N N   . LEU   A 1 158 ? -4.67422  74.48519 9.54820   1.000 27.15466 ? 276 LEU   A N   1 
ATOM   805  C CA  . LEU   A 1 158 ? -4.13058  74.59808 8.19449   1.000 29.68528 ? 276 LEU   A CA  1 
ATOM   806  C C   . LEU   A 1 158 ? -2.95274  75.56447 8.15536   1.000 32.08688 ? 276 LEU   A C   1 
ATOM   807  O O   . LEU   A 1 158 ? -1.93463  75.27862 7.51657   1.000 28.32947 ? 276 LEU   A O   1 
ATOM   808  C CB  . LEU   A 1 158 ? -5.22674  75.03588 7.22523   1.000 28.15834 ? 276 LEU   A CB  1 
ATOM   809  C CG  . LEU   A 1 158 ? -6.22668  73.96166 6.80539   1.000 30.22505 ? 276 LEU   A CG  1 
ATOM   810  C CD1 . LEU   A 1 158 ? -7.42984  74.60673 6.13135   1.000 28.57982 ? 276 LEU   A CD1 1 
ATOM   811  C CD2 . LEU   A 1 158 ? -5.54920  72.95711 5.84985   1.000 30.00936 ? 276 LEU   A CD2 1 
ATOM   812  N N   . LYS   A 1 159 ? -3.06814  76.71225 8.83655   1.000 27.98281 ? 277 LYS   A N   1 
ATOM   813  C CA  . LYS   A 1 159 ? -1.92493  77.61974 8.96765   1.000 33.25986 ? 277 LYS   A CA  1 
ATOM   814  C C   . LYS   A 1 159 ? -0.73040  76.91687 9.59250   1.000 34.09012 ? 277 LYS   A C   1 
ATOM   815  O O   . LYS   A 1 159 ? 0.41861   77.15646 9.19687   1.000 32.50774 ? 277 LYS   A O   1 
ATOM   816  C CB  . LYS   A 1 159 ? -2.30516  78.84799 9.80504   1.000 30.05729 ? 277 LYS   A CB  1 
ATOM   817  C CG  . LYS   A 1 159 ? -3.25898  79.80257 9.11457   1.000 32.48043 ? 277 LYS   A CG  1 
ATOM   818  C CD  . LYS   A 1 159 ? -3.41833  81.11984 9.88192   1.000 39.28212 ? 277 LYS   A CD  1 
ATOM   819  C CE  . LYS   A 1 159 ? -4.48438  81.99536 9.21444   1.000 47.98411 ? 277 LYS   A CE  1 
ATOM   820  N NZ  . LYS   A 1 159 ? -4.76198  83.27874 9.94571   1.000 49.97859 ? 277 LYS   A NZ  1 
ATOM   821  N N   . GLY   A 1 160 ? -0.97890  76.04518 10.57640  1.000 29.19632 ? 278 GLY   A N   1 
ATOM   822  C CA  . GLY   A 1 160 ? 0.12000   75.36940 11.23607  1.000 30.30421 ? 278 GLY   A CA  1 
ATOM   823  C C   . GLY   A 1 160 ? 0.78144   74.29035 10.39432  1.000 26.16410 ? 278 GLY   A C   1 
ATOM   824  O O   . GLY   A 1 160 ? 1.99256   74.08610 10.49399  1.000 28.89821 ? 278 GLY   A O   1 
ATOM   825  N N   . ALA   A 1 161 ? 0.00866   73.58807 9.56143   1.000 29.93919 ? 279 ALA   A N   1 
ATOM   826  C CA  . ALA   A 1 161 ? 0.48299   72.36692 8.91351   1.000 30.87988 ? 279 ALA   A CA  1 
ATOM   827  C C   . ALA   A 1 161 ? 0.70475   72.48622 7.41265   1.000 28.65592 ? 279 ALA   A C   1 
ATOM   828  O O   . ALA   A 1 161 ? 1.24906   71.54497 6.82037   1.000 28.52805 ? 279 ALA   A O   1 
ATOM   829  C CB  . ALA   A 1 161 ? -0.50236  71.20572 9.14745   1.000 25.27772 ? 279 ALA   A CB  1 
ATOM   830  N N   . ALA   A 1 162 ? 0.28693   73.58950 6.77958   1.000 23.68778 ? 280 ALA   A N   1 
ATOM   831  C CA  . ALA   A 1 162 ? 0.26489   73.63653 5.31417   1.000 29.51668 ? 280 ALA   A CA  1 
ATOM   832  C C   . ALA   A 1 162 ? 1.62489   73.29537 4.71098   1.000 26.58313 ? 280 ALA   A C   1 
ATOM   833  O O   . ALA   A 1 162 ? 1.70987   72.52772 3.74635   1.000 25.11171 ? 280 ALA   A O   1 
ATOM   834  C CB  . ALA   A 1 162 ? -0.18756  75.01061 4.83150   1.000 26.42445 ? 280 ALA   A CB  1 
ATOM   835  N N   . PHE   A 1 163 ? 2.69511   73.87016 5.25586   1.000 25.01724 ? 281 PHE   A N   1 
ATOM   836  C CA  . PHE   A 1 163 ? 4.03789   73.57279 4.76568   1.000 27.07460 ? 281 PHE   A CA  1 
ATOM   837  C C   . PHE   A 1 163 ? 4.37323   72.09216 4.92385   1.000 24.60001 ? 281 PHE   A C   1 
ATOM   838  O O   . PHE   A 1 163 ? 5.00828   71.49229 4.04878   1.000 19.86190 ? 281 PHE   A O   1 
ATOM   839  C CB  . PHE   A 1 163 ? 5.06753   74.42154 5.52274   1.000 25.89516 ? 281 PHE   A CB  1 
ATOM   840  C CG  . PHE   A 1 163 ? 6.50713   74.03390 5.25015   1.000 26.28635 ? 281 PHE   A CG  1 
ATOM   841  C CD1 . PHE   A 1 163 ? 7.20076   74.59857 4.17978   1.000 30.76351 ? 281 PHE   A CD1 1 
ATOM   842  C CD2 . PHE   A 1 163 ? 7.16489   73.11985 6.05799   1.000 28.72543 ? 281 PHE   A CD2 1 
ATOM   843  C CE1 . PHE   A 1 163 ? 8.51682   74.26718 3.92177   1.000 31.81527 ? 281 PHE   A CE1 1 
ATOM   844  C CE2 . PHE   A 1 163 ? 8.49356   72.76510 5.79871   1.000 33.63428 ? 281 PHE   A CE2 1 
ATOM   845  C CZ  . PHE   A 1 163 ? 9.16615   73.33726 4.72570   1.000 31.10285 ? 281 PHE   A CZ  1 
ATOM   846  N N   . GLU   A 1 164 ? 4.03795   71.51049 6.07931   1.000 21.63578 ? 282 GLU   A N   1 
ATOM   847  C CA  . GLU   A 1 164 ? 4.39059   70.11699 6.33823   1.000 24.57713 ? 282 GLU   A CA  1 
ATOM   848  C C   . GLU   A 1 164 ? 3.65399   69.18501 5.39553   1.000 19.35630 ? 282 GLU   A C   1 
ATOM   849  O O   . GLU   A 1 164 ? 4.24362   68.23142 4.87972   1.000 22.72084 ? 282 GLU   A O   1 
ATOM   850  C CB  . GLU   A 1 164 ? 4.09429   69.73699 7.80143   1.000 20.71879 ? 282 GLU   A CB  1 
ATOM   851  C CG  . GLU   A 1 164 ? 4.82903   70.62885 8.78326   1.000 24.56885 ? 282 GLU   A CG  1 
ATOM   852  C CD  . GLU   A 1 164 ? 4.46239   70.37021 10.23331  1.000 30.09950 ? 282 GLU   A CD  1 
ATOM   853  O OE1 . GLU   A 1 164 ? 3.84584   69.31754 10.54421  1.000 25.36074 ? 282 GLU   A OE1 1 
ATOM   854  O OE2 . GLU   A 1 164 ? 4.79517   71.23828 11.05782  1.000 28.12791 ? 282 GLU   A OE2 1 
ATOM   855  N N   . LEU   A 1 165 ? 2.36258   69.43277 5.17201   1.000 21.55495 ? 283 LEU   A N   1 
ATOM   856  C CA  . LEU   A 1 165 ? 1.61200   68.58397 4.25460   1.000 22.13832 ? 283 LEU   A CA  1 
ATOM   857  C C   . LEU   A 1 165 ? 2.10930   68.74955 2.82140   1.000 21.50745 ? 283 LEU   A C   1 
ATOM   858  O O   . LEU   A 1 165 ? 2.16581   67.77704 2.06758   1.000 19.77494 ? 283 LEU   A O   1 
ATOM   859  C CB  . LEU   A 1 165 ? 0.11737   68.89426 4.33303   1.000 23.26266 ? 283 LEU   A CB  1 
ATOM   860  C CG  . LEU   A 1 165 ? -0.59845  67.95856 5.34273   1.000 28.76854 ? 283 LEU   A CG  1 
ATOM   861  C CD1 . LEU   A 1 165 ? -0.22427  68.29558 6.73934   1.000 28.31582 ? 283 LEU   A CD1 1 
ATOM   862  C CD2 . LEU   A 1 165 ? -2.11004  67.98392 5.18390   1.000 34.44306 ? 283 LEU   A CD2 1 
ATOM   863  N N   . CYS   A 1 166 ? 2.44909   69.97417 2.42817   1.000 20.36747 ? 284 CYS   A N   1 
ATOM   864  C CA  . CYS   A 1 166 ? 3.02901   70.19016 1.10348   1.000 23.40408 ? 284 CYS   A CA  1 
ATOM   865  C C   . CYS   A 1 166 ? 4.29888   69.35699 0.91324   1.000 21.49506 ? 284 CYS   A C   1 
ATOM   866  O O   . CYS   A 1 166 ? 4.48533   68.71393 -0.12290  1.000 23.69787 ? 284 CYS   A O   1 
ATOM   867  C CB  . CYS   A 1 166 ? 3.32383   71.68013 0.92226   1.000 24.86937 ? 284 CYS   A CB  1 
ATOM   868  S SG  . CYS   A 1 166 ? 4.00812   72.08257 -0.68529  1.000 32.31696 ? 284 CYS   A SG  1 
ATOM   869  N N   . GLN   A 1 167 ? 5.19419   69.37863 1.90426   1.000 21.10375 ? 285 GLN   A N   1 
ATOM   870  C CA  . GLN   A 1 167 ? 6.44328   68.62251 1.81734   1.000 23.23154 ? 285 GLN   A CA  1 
ATOM   871  C C   . GLN   A 1 167 ? 6.19612   67.11758 1.78417   1.000 21.38245 ? 285 GLN   A C   1 
ATOM   872  O O   . GLN   A 1 167 ? 6.91236   66.39124 1.08573   1.000 21.47664 ? 285 GLN   A O   1 
ATOM   873  C CB  . GLN   A 1 167 ? 7.36058   68.98393 2.99121   1.000 21.29206 ? 285 GLN   A CB  1 
ATOM   874  C CG  . GLN   A 1 167 ? 7.99524   70.41067 2.90726   1.000 26.48718 ? 285 GLN   A CG  1 
ATOM   875  C CD  . GLN   A 1 167 ? 8.56820   70.72440 1.51810   1.000 31.39244 ? 285 GLN   A CD  1 
ATOM   876  O OE1 . GLN   A 1 167 ? 9.37774   69.97730 0.98429   1.000 29.25539 ? 285 GLN   A OE1 1 
ATOM   877  N NE2 . GLN   A 1 167 ? 8.12075   71.81984 0.92612   1.000 35.19539 ? 285 GLN   A NE2 1 
ATOM   878  N N   . LEU   A 1 168 ? 5.22021   66.62349 2.56139   1.000 20.00014 ? 286 LEU   A N   1 
ATOM   879  C CA  . LEU   A 1 168 ? 4.87693   65.19930 2.51170   1.000 22.17777 ? 286 LEU   A CA  1 
ATOM   880  C C   . LEU   A 1 168 ? 4.38713   64.79801 1.12404   1.000 21.30883 ? 286 LEU   A C   1 
ATOM   881  O O   . LEU   A 1 168 ? 4.78681   63.75470 0.58779   1.000 17.87167 ? 286 LEU   A O   1 
ATOM   882  C CB  . LEU   A 1 168 ? 3.81730   64.86082 3.57369   1.000 18.43615 ? 286 LEU   A CB  1 
ATOM   883  C CG  . LEU   A 1 168 ? 4.33110   64.93637 5.01917   1.000 20.20845 ? 286 LEU   A CG  1 
ATOM   884  C CD1 . LEU   A 1 168 ? 3.18398   64.84370 6.08102   1.000 24.00568 ? 286 LEU   A CD1 1 
ATOM   885  C CD2 . LEU   A 1 168 ? 5.37522   63.82501 5.24447   1.000 20.84406 ? 286 LEU   A CD2 1 
ATOM   886  N N   . ARG   A 1 169 ? 3.49531   65.60004 0.53288   1.000 17.30433 ? 287 ARG   A N   1 
ATOM   887  C CA  . ARG   A 1 169 ? 3.07344   65.32464 -0.83602  1.000 17.02443 ? 287 ARG   A CA  1 
ATOM   888  C C   . ARG   A 1 169 ? 4.24297   65.41488 -1.81453  1.000 16.61511 ? 287 ARG   A C   1 
ATOM   889  O O   . ARG   A 1 169 ? 4.37874   64.55880 -2.69560  1.000 18.64161 ? 287 ARG   A O   1 
ATOM   890  C CB  . ARG   A 1 169 ? 1.94184   66.28214 -1.24396  1.000 17.60948 ? 287 ARG   A CB  1 
ATOM   891  C CG  . ARG   A 1 169 ? 0.60340   65.85759 -0.60025  1.000 19.79510 ? 287 ARG   A CG  1 
ATOM   892  C CD  . ARG   A 1 169 ? -0.58326  66.60704 -1.25897  1.000 22.91965 ? 287 ARG   A CD  1 
ATOM   893  N NE  . ARG   A 1 169 ? -1.86783  65.98563 -0.93667  1.000 22.99202 ? 287 ARG   A NE  1 
ATOM   894  C CZ  . ARG   A 1 169 ? -3.04832  66.45123 -1.34046  1.000 24.31075 ? 287 ARG   A CZ  1 
ATOM   895  N NH1 . ARG   A 1 169 ? -3.10803  67.56066 -2.08410  1.000 24.03968 ? 287 ARG   A NH1 1 
ATOM   896  N NH2 . ARG   A 1 169 ? -4.16177  65.78032 -1.04942  1.000 20.55165 ? 287 ARG   A NH2 1 
ATOM   897  N N   . PHE   A 1 170 ? 5.10684   66.43764 -1.67848  1.000 18.86038 ? 288 PHE   A N   1 
ATOM   898  C CA  . PHE   A 1 170 ? 6.26064   66.50472 -2.57957  1.000 21.35446 ? 288 PHE   A CA  1 
ATOM   899  C C   . PHE   A 1 170 ? 7.18502   65.30539 -2.43678  1.000 22.12258 ? 288 PHE   A C   1 
ATOM   900  O O   . PHE   A 1 170 ? 7.83015   64.92127 -3.41667  1.000 19.20392 ? 288 PHE   A O   1 
ATOM   901  C CB  . PHE   A 1 170 ? 7.09447   67.77369 -2.40762  1.000 20.41266 ? 288 PHE   A CB  1 
ATOM   902  C CG  . PHE   A 1 170 ? 6.57301   68.96421 -3.15843  1.000 23.99444 ? 288 PHE   A CG  1 
ATOM   903  C CD1 . PHE   A 1 170 ? 6.46673   68.93125 -4.55024  1.000 30.23772 ? 288 PHE   A CD1 1 
ATOM   904  C CD2 . PHE   A 1 170 ? 6.34543   70.15593 -2.51794  1.000 26.61518 ? 288 PHE   A CD2 1 
ATOM   905  C CE1 . PHE   A 1 170 ? 6.01618   70.03712 -5.26717  1.000 28.51719 ? 288 PHE   A CE1 1 
ATOM   906  C CE2 . PHE   A 1 170 ? 5.91166   71.28341 -3.24638  1.000 29.90082 ? 288 PHE   A CE2 1 
ATOM   907  C CZ  . PHE   A 1 170 ? 5.74738   71.21053 -4.61099  1.000 26.18229 ? 288 PHE   A CZ  1 
ATOM   908  N N   . ASN   A 1 171 ? 7.27143   64.69213 -1.25005  1.000 19.18775 ? 289 ASN   A N   1 
ATOM   909  C CA  . ASN   A 1 171 ? 8.14630   63.52428 -1.12490  1.000 19.76937 ? 289 ASN   A CA  1 
ATOM   910  C C   . ASN   A 1 171 ? 7.68155   62.37200 -2.00969  1.000 21.84801 ? 289 ASN   A C   1 
ATOM   911  O O   . ASN   A 1 171 ? 8.51059   61.60278 -2.51449  1.000 21.63663 ? 289 ASN   A O   1 
ATOM   912  C CB  . ASN   A 1 171 ? 8.24377   63.06214 0.34007   1.000 21.54641 ? 289 ASN   A CB  1 
ATOM   913  C CG  . ASN   A 1 171 ? 9.41355   62.11964 0.57385   1.000 23.82288 ? 289 ASN   A CG  1 
ATOM   914  O OD1 . ASN   A 1 171 ? 10.58533  62.53966 0.55388   1.000 26.80854 ? 289 ASN   A OD1 1 
ATOM   915  N ND2 . ASN   A 1 171 ? 9.11495   60.84312 0.73731   1.000 18.27748 ? 289 ASN   A ND2 1 
ATOM   916  N N   . THR   A 1 172 ? 6.37166   62.23567 -2.22732  1.000 21.36518 ? 290 THR   A N   1 
ATOM   917  C CA  . THR   A 1 172 ? 5.89449   61.12927 -3.04866  1.000 22.52616 ? 290 THR   A CA  1 
ATOM   918  C C   . THR   A 1 172 ? 6.22188   61.31185 -4.53120  1.000 23.29223 ? 290 THR   A C   1 
ATOM   919  O O   . THR   A 1 172 ? 6.11319   60.35171 -5.29553  1.000 23.46180 ? 290 THR   A O   1 
ATOM   920  C CB  . THR   A 1 172 ? 4.38050   60.92869 -2.87125  1.000 24.17709 ? 290 THR   A CB  1 
ATOM   921  O OG1 . THR   A 1 172 ? 3.65972   62.04331 -3.42780  1.000 22.05521 ? 290 THR   A OG1 1 
ATOM   922  C CG2 . THR   A 1 172 ? 4.01070   60.77856 -1.37391  1.000 22.73816 ? 290 THR   A CG2 1 
ATOM   923  N N   . VAL   A 1 173 ? 6.61536   62.50422 -4.96749  1.000 21.65784 ? 291 VAL   A N   1 
ATOM   924  C CA  . VAL   A 1 173 ? 7.06106   62.68569 -6.34842  1.000 23.46567 ? 291 VAL   A CA  1 
ATOM   925  C C   . VAL   A 1 173 ? 8.55894   62.94071 -6.41663  1.000 24.04351 ? 291 VAL   A C   1 
ATOM   926  O O   . VAL   A 1 173 ? 9.08189   63.31639 -7.48120  1.000 24.99897 ? 291 VAL   A O   1 
ATOM   927  C CB  . VAL   A 1 173 ? 6.28191   63.80575 -7.05684  1.000 22.43583 ? 291 VAL   A CB  1 
ATOM   928  C CG1 . VAL   A 1 173 ? 4.78917   63.46733 -7.13013  1.000 25.05963 ? 291 VAL   A CG1 1 
ATOM   929  C CG2 . VAL   A 1 173 ? 6.54280   65.13585 -6.38577  1.000 23.24550 ? 291 VAL   A CG2 1 
ATOM   930  N N   . PHE   A 1 174 ? 9.26139   62.78421 -5.29540  1.000 24.91833 ? 292 PHE   A N   1 
ATOM   931  C CA  . PHE   A 1 174 ? 10.70874  62.97425 -5.25968  1.000 23.82507 ? 292 PHE   A CA  1 
ATOM   932  C C   . PHE   A 1 174 ? 11.39705  61.72834 -5.80083  1.000 26.66092 ? 292 PHE   A C   1 
ATOM   933  O O   . PHE   A 1 174 ? 11.08570  60.60803 -5.38805  1.000 27.80637 ? 292 PHE   A O   1 
ATOM   934  C CB  . PHE   A 1 174 ? 11.19204  63.26278 -3.83338  1.000 21.30817 ? 292 PHE   A CB  1 
ATOM   935  C CG  . PHE   A 1 174 ? 12.66155  63.60911 -3.74632  1.000 28.49851 ? 292 PHE   A CG  1 
ATOM   936  C CD1 . PHE   A 1 174 ? 13.18457  64.66308 -4.48936  1.000 25.68258 ? 292 PHE   A CD1 1 
ATOM   937  C CD2 . PHE   A 1 174 ? 13.52270  62.87879 -2.93360  1.000 30.60891 ? 292 PHE   A CD2 1 
ATOM   938  C CE1 . PHE   A 1 174 ? 14.53965  64.98759 -4.41860  1.000 26.84791 ? 292 PHE   A CE1 1 
ATOM   939  C CE2 . PHE   A 1 174 ? 14.88633  63.19483 -2.85534  1.000 27.65096 ? 292 PHE   A CE2 1 
ATOM   940  C CZ  . PHE   A 1 174 ? 15.39480  64.25267 -3.59945  1.000 27.16499 ? 292 PHE   A CZ  1 
ATOM   941  N N   . ASN   A 1 175 ? 12.32052  61.91894 -6.74378  1.000 25.22011 ? 293 ASN   A N   1 
ATOM   942  C CA  . ASN   A 1 175 ? 13.13206  60.82105 -7.27056  1.000 31.45076 ? 293 ASN   A CA  1 
ATOM   943  C C   . ASN   A 1 175 ? 14.49066  60.92274 -6.59664  1.000 31.40082 ? 293 ASN   A C   1 
ATOM   944  O O   . ASN   A 1 175 ? 15.28818  61.80319 -6.93108  1.000 30.25679 ? 293 ASN   A O   1 
ATOM   945  C CB  . ASN   A 1 175 ? 13.25658  60.88618 -8.79733  1.000 32.92745 ? 293 ASN   A CB  1 
ATOM   946  C CG  . ASN   A 1 175 ? 13.99233  59.67380 -9.38278  1.000 35.38333 ? 293 ASN   A CG  1 
ATOM   947  O OD1 . ASN   A 1 175 ? 14.93297  59.14623 -8.78231  1.000 30.29761 ? 293 ASN   A OD1 1 
ATOM   948  N ND2 . ASN   A 1 175 ? 13.55417  59.22829 -10.54806 1.000 38.66334 ? 293 ASN   A ND2 1 
ATOM   949  N N   . ALA   A 1 176 ? 14.75303  60.03536 -5.63223  1.000 28.07096 ? 294 ALA   A N   1 
ATOM   950  C CA  . ALA   A 1 176 ? 15.99534  60.15206 -4.87486  1.000 32.04337 ? 294 ALA   A CA  1 
ATOM   951  C C   . ALA   A 1 176 ? 17.20751  59.74733 -5.70367  1.000 31.14626 ? 294 ALA   A C   1 
ATOM   952  O O   . ALA   A 1 176 ? 18.32065  60.18826 -5.40900  1.000 40.49519 ? 294 ALA   A O   1 
ATOM   953  C CB  . ALA   A 1 176 ? 15.93258  59.30410 -3.59947  1.000 32.85686 ? 294 ALA   A CB  1 
ATOM   954  N N   . GLU   A 1 177 ? 17.01145  58.93012 -6.73356  1.000 35.25710 ? 295 GLU   A N   1 
ATOM   955  C CA  . GLU   A 1 177 ? 18.12669  58.54340 -7.59347  1.000 40.12995 ? 295 GLU   A CA  1 
ATOM   956  C C   . GLU   A 1 177 ? 18.61381  59.72122 -8.43239  1.000 39.15157 ? 295 GLU   A C   1 
ATOM   957  O O   . GLU   A 1 177 ? 19.82185  59.87903 -8.64520  1.000 35.59349 ? 295 GLU   A O   1 
ATOM   958  C CB  . GLU   A 1 177 ? 17.70936  57.37564 -8.48746  1.000 38.02648 ? 295 GLU   A CB  1 
ATOM   959  C CG  . GLU   A 1 177 ? 17.81236  56.01806 -7.80983  1.000 46.57526 ? 295 GLU   A CG  1 
ATOM   960  C CD  . GLU   A 1 177 ? 16.96707  55.92007 -6.54825  1.000 59.66223 ? 295 GLU   A CD  1 
ATOM   961  O OE1 . GLU   A 1 177 ? 17.54984  55.83182 -5.43876  1.000 59.02495 ? 295 GLU   A OE1 1 
ATOM   962  O OE2 . GLU   A 1 177 ? 15.71773  55.92980 -6.66791  1.000 63.89932 ? 295 GLU   A OE2 1 
ATOM   963  N N   . THR   A 1 178 ? 17.69809  60.57611 -8.89915  1.000 34.69206 ? 296 THR   A N   1 
ATOM   964  C CA  . THR   A 1 178 ? 18.07607  61.70842 -9.73290  1.000 34.02480 ? 296 THR   A CA  1 
ATOM   965  C C   . THR   A 1 178 ? 18.00858  63.04758 -9.00969  1.000 38.89922 ? 296 THR   A C   1 
ATOM   966  O O   . THR   A 1 178 ? 18.25370  64.08094 -9.63977  1.000 34.76818 ? 296 THR   A O   1 
ATOM   967  C CB  . THR   A 1 178 ? 17.19823  61.74516 -10.99061 1.000 37.06010 ? 296 THR   A CB  1 
ATOM   968  O OG1 . THR   A 1 178 ? 15.85595  62.10648 -10.63777 1.000 34.23220 ? 296 THR   A OG1 1 
ATOM   969  C CG2 . THR   A 1 178 ? 17.17267  60.36188 -11.65275 1.000 38.87378 ? 296 THR   A CG2 1 
ATOM   970  N N   . GLY   A 1 179 ? 17.71047  63.06523 -7.70686  1.000 29.21398 ? 297 GLY   A N   1 
ATOM   971  C CA  . GLY   A 1 179 ? 17.51329  64.32300 -7.00788  1.000 29.53140 ? 297 GLY   A CA  1 
ATOM   972  C C   . GLY   A 1 179 ? 16.50733  65.24184 -7.69024  1.000 28.10686 ? 297 GLY   A C   1 
ATOM   973  O O   . GLY   A 1 179 ? 16.77681  66.43226 -7.84769  1.000 31.86278 ? 297 GLY   A O   1 
ATOM   974  N N   . THR   A 1 180 ? 15.34032  64.71922 -8.06945  1.000 26.34436 ? 298 THR   A N   1 
ATOM   975  C CA  . THR   A 1 180 ? 14.37740  65.45891 -8.88922  1.000 31.26433 ? 298 THR   A CA  1 
ATOM   976  C C   . THR   A 1 180 ? 12.95146  65.29258 -8.37554  1.000 29.21633 ? 298 THR   A C   1 
ATOM   977  O O   . THR   A 1 180 ? 12.48387  64.16622 -8.18943  1.000 27.05407 ? 298 THR   A O   1 
ATOM   978  C CB  . THR   A 1 180 ? 14.44946  64.98031 -10.34820 1.000 29.56878 ? 298 THR   A CB  1 
ATOM   979  O OG1 . THR   A 1 180 ? 15.77528  65.19458 -10.83259 1.000 31.15321 ? 298 THR   A OG1 1 
ATOM   980  C CG2 . THR   A 1 180 ? 13.42933  65.73421 -11.24722 1.000 28.29469 ? 298 THR   A CG2 1 
ATOM   981  N N   . TRP   A 1 181 ? 12.24838  66.40543 -8.17539  1.000 25.56271 ? 299 TRP   A N   1 
ATOM   982  C CA  . TRP   A 1 181 ? 10.81340  66.34742 -7.93398  1.000 24.15066 ? 299 TRP   A CA  1 
ATOM   983  C C   . TRP   A 1 181 ? 10.12786  66.34277 -9.29399  1.000 26.75137 ? 299 TRP   A C   1 
ATOM   984  O O   . TRP   A 1 181 ? 10.24439  67.30746 -10.05735 1.000 24.78919 ? 299 TRP   A O   1 
ATOM   985  C CB  . TRP   A 1 181 ? 10.33352  67.51479 -7.08365  1.000 21.20211 ? 299 TRP   A CB  1 
ATOM   986  C CG  . TRP   A 1 181 ? 10.83072  67.43090 -5.64152  1.000 27.69157 ? 299 TRP   A CG  1 
ATOM   987  C CD1 . TRP   A 1 181 ? 10.22200  66.79607 -4.57709  1.000 25.13120 ? 299 TRP   A CD1 1 
ATOM   988  C CD2 . TRP   A 1 181 ? 12.04474  67.98301 -5.14030  1.000 27.67461 ? 299 TRP   A CD2 1 
ATOM   989  N NE1 . TRP   A 1 181 ? 10.99094  66.94290 -3.43927  1.000 24.82884 ? 299 TRP   A NE1 1 
ATOM   990  C CE2 . TRP   A 1 181 ? 12.11546  67.66770 -3.76170  1.000 26.61400 ? 299 TRP   A CE2 1 
ATOM   991  C CE3 . TRP   A 1 181 ? 13.08648  68.73001 -5.72521  1.000 28.60884 ? 299 TRP   A CE3 1 
ATOM   992  C CZ2 . TRP   A 1 181 ? 13.18612  68.06858 -2.96116  1.000 27.44431 ? 299 TRP   A CZ2 1 
ATOM   993  C CZ3 . TRP   A 1 181 ? 14.14667  69.13124 -4.92375  1.000 29.51561 ? 299 TRP   A CZ3 1 
ATOM   994  C CH2 . TRP   A 1 181 ? 14.18623  68.79941 -3.55659  1.000 32.62109 ? 299 TRP   A CH2 1 
ATOM   995  N N   . GLU   A 1 182 ? 9.43000   65.26097 -9.58464  1.000 24.57230 ? 300 GLU   A N   1 
ATOM   996  C CA  A GLU   A 1 182 ? 8.85624   64.99481 -10.89606 0.994 25.76351 ? 300 GLU   A CA  1 
ATOM   997  C C   . GLU   A 1 182 ? 7.39020   65.36818 -10.82090 1.000 26.71596 ? 300 GLU   A C   1 
ATOM   998  O O   . GLU   A 1 182 ? 6.56757   64.59973 -10.31931 1.000 29.25668 ? 300 GLU   A O   1 
ATOM   999  C CB  A GLU   A 1 182 ? 9.04753   63.53297 -11.27886 0.994 29.71950 ? 300 GLU   A CB  1 
ATOM   1000 C CG  A GLU   A 1 182 ? 10.49550  63.08766 -11.22191 0.994 32.99107 ? 300 GLU   A CG  1 
ATOM   1001 C CD  A GLU   A 1 182 ? 10.68427  61.64372 -11.65607 0.994 40.55044 ? 300 GLU   A CD  1 
ATOM   1002 O OE1 A GLU   A 1 182 ? 11.82100  61.26815 -12.02886 0.994 42.68793 ? 300 GLU   A OE1 1 
ATOM   1003 O OE2 A GLU   A 1 182 ? 9.69342   60.88335 -11.61765 0.994 52.37307 ? 300 GLU   A OE2 1 
ATOM   1004 N N   . CYS   A 1 183 ? 7.06470   66.55927 -11.30225 1.000 23.08129 ? 301 CYS   A N   1 
ATOM   1005 C CA  . CYS   A 1 183 ? 5.72450   67.10825 -11.15513 1.000 26.91909 ? 301 CYS   A CA  1 
ATOM   1006 C C   . CYS   A 1 183 ? 5.01884   67.12047 -12.50365 1.000 27.38752 ? 301 CYS   A C   1 
ATOM   1007 O O   . CYS   A 1 183 ? 4.75276   68.17306 -13.08384 1.000 25.56720 ? 301 CYS   A O   1 
ATOM   1008 C CB  . CYS   A 1 183 ? 5.78615   68.51143 -10.53122 1.000 23.09659 ? 301 CYS   A CB  1 
ATOM   1009 S SG  . CYS   A 1 183 ? 6.66392   68.58425 -8.94838  1.000 25.95994 ? 301 CYS   A SG  1 
ATOM   1010 N N   . GLY   A 1 184 ? 4.69548   65.93087 -12.98533 1.000 26.38111 ? 302 GLY   A N   1 
ATOM   1011 C CA  . GLY   A 1 184 ? 4.03939   65.82062 -14.27571 1.000 32.76597 ? 302 GLY   A CA  1 
ATOM   1012 C C   . GLY   A 1 184 ? 4.96666   66.31321 -15.37602 1.000 31.34861 ? 302 GLY   A C   1 
ATOM   1013 O O   . GLY   A 1 184 ? 6.07675   65.80313 -15.56124 1.000 28.54626 ? 302 GLY   A O   1 
ATOM   1014 N N   . ARG   A 1 185 ? 4.52485   67.34893 -16.08411 1.000 30.72730 ? 303 ARG   A N   1 
ATOM   1015 C CA  . ARG   A 1 185 ? 5.29121   67.94129 -17.17412 1.000 33.39838 ? 303 ARG   A CA  1 
ATOM   1016 C C   . ARG   A 1 185 ? 6.42865   68.82533 -16.68439 1.000 33.89927 ? 303 ARG   A C   1 
ATOM   1017 O O   . ARG   A 1 185 ? 7.29404   69.20160 -17.48711 1.000 32.66149 ? 303 ARG   A O   1 
ATOM   1018 C CB  . ARG   A 1 185 ? 4.35475   68.75608 -18.07837 1.000 34.06169 ? 303 ARG   A CB  1 
ATOM   1019 N N   . LEU   A 1 186 ? 6.42357   69.18932 -15.40676 1.000 27.16817 ? 304 LEU   A N   1 
ATOM   1020 C CA  . LEU   A 1 186 ? 7.47739   69.97539 -14.78685 1.000 28.15618 ? 304 LEU   A CA  1 
ATOM   1021 C C   . LEU   A 1 186 ? 8.38143   69.06191 -13.97114 1.000 33.98935 ? 304 LEU   A C   1 
ATOM   1022 O O   . LEU   A 1 186 ? 7.90043   68.15468 -13.28428 1.000 30.89842 ? 304 LEU   A O   1 
ATOM   1023 C CB  . LEU   A 1 186 ? 6.88085   71.04898 -13.88172 1.000 25.75827 ? 304 LEU   A CB  1 
ATOM   1024 C CG  . LEU   A 1 186 ? 6.23195   72.28540 -14.49287 1.000 34.42854 ? 304 LEU   A CG  1 
ATOM   1025 C CD1 . LEU   A 1 186 ? 5.36537   72.96839 -13.46569 1.000 38.07704 ? 304 LEU   A CD1 1 
ATOM   1026 C CD2 . LEU   A 1 186 ? 7.34748   73.22731 -14.86814 1.000 40.78617 ? 304 LEU   A CD2 1 
ATOM   1027 N N   . SER   A 1 187 ? 9.68852   69.31396 -14.04365 1.000 29.97546 ? 305 SER   A N   1 
ATOM   1028 C CA  . SER   A 1 187 ? 10.69345  68.59788 -13.26805 1.000 31.65831 ? 305 SER   A CA  1 
ATOM   1029 C C   . SER   A 1 187 ? 11.63229  69.61184 -12.63350 1.000 34.18250 ? 305 SER   A C   1 
ATOM   1030 O O   . SER   A 1 187 ? 12.06592  70.56620 -13.29362 1.000 32.05604 ? 305 SER   A O   1 
ATOM   1031 C CB  . SER   A 1 187 ? 11.49741  67.62531 -14.14106 1.000 30.86021 ? 305 SER   A CB  1 
ATOM   1032 O OG  . SER   A 1 187 ? 10.68994  66.56266 -14.57883 1.000 43.38700 ? 305 SER   A OG  1 
ATOM   1033 N N   . TYR   A 1 188 ? 11.93997  69.41670 -11.35444 1.000 24.54959 ? 306 TYR   A N   1 
ATOM   1034 C CA  . TYR   A 1 188 ? 12.84465  70.30412 -10.62976 1.000 28.38594 ? 306 TYR   A CA  1 
ATOM   1035 C C   . TYR   A 1 188 ? 14.01369  69.47281 -10.12143 1.000 34.38112 ? 306 TYR   A C   1 
ATOM   1036 O O   . TYR   A 1 188 ? 13.82148  68.58109 -9.29130  1.000 28.29421 ? 306 TYR   A O   1 
ATOM   1037 C CB  . TYR   A 1 188 ? 12.13039  70.99293 -9.46271  1.000 29.08177 ? 306 TYR   A CB  1 
ATOM   1038 C CG  . TYR   A 1 188 ? 10.85792  71.71135 -9.84054  1.000 28.71386 ? 306 TYR   A CG  1 
ATOM   1039 C CD1 . TYR   A 1 188 ? 9.63729   71.04108 -9.85764  1.000 28.95739 ? 306 TYR   A CD1 1 
ATOM   1040 C CD2 . TYR   A 1 188 ? 10.87328  73.06468 -10.17247 1.000 27.87870 ? 306 TYR   A CD2 1 
ATOM   1041 C CE1 . TYR   A 1 188 ? 8.46366   71.69401 -10.19849 1.000 31.41722 ? 306 TYR   A CE1 1 
ATOM   1042 C CE2 . TYR   A 1 188 ? 9.70001   73.73101 -10.51756 1.000 29.17116 ? 306 TYR   A CE2 1 
ATOM   1043 C CZ  . TYR   A 1 188 ? 8.50519   73.04093 -10.52673 1.000 26.85181 ? 306 TYR   A CZ  1 
ATOM   1044 O OH  . TYR   A 1 188 ? 7.34719   73.68754 -10.85495 1.000 26.35163 ? 306 TYR   A OH  1 
ATOM   1045 N N   . CYS   A 1 189 ? 15.21868  69.77881 -10.59552 1.000 31.42987 ? 307 CYS   A N   1 
ATOM   1046 C CA  . CYS   A 1 189 ? 16.40063  68.95701 -10.35241 1.000 31.58144 ? 307 CYS   A CA  1 
ATOM   1047 C C   . CYS   A 1 189 ? 17.41699  69.73961 -9.54002  1.000 35.12170 ? 307 CYS   A C   1 
ATOM   1048 O O   . CYS   A 1 189 ? 17.80155  70.84861 -9.92263  1.000 32.36591 ? 307 CYS   A O   1 
ATOM   1049 C CB  . CYS   A 1 189 ? 17.03553  68.49769 -11.67742 1.000 37.70537 ? 307 CYS   A CB  1 
ATOM   1050 S SG  . CYS   A 1 189 ? 18.37505  67.27548 -11.49267 1.000 38.08439 ? 307 CYS   A SG  1 
ATOM   1051 N N   . LEU   A 1 190 ? 17.85213  69.15651 -8.42530  1.000 32.79691 ? 308 LEU   A N   1 
ATOM   1052 C CA  . LEU   A 1 190 ? 18.90509  69.75714 -7.61552  1.000 37.23550 ? 308 LEU   A CA  1 
ATOM   1053 C C   . LEU   A 1 190 ? 20.19075  69.89939 -8.42237  1.000 42.54788 ? 308 LEU   A C   1 
ATOM   1054 O O   . LEU   A 1 190 ? 20.68011  68.93229 -9.00891  1.000 43.28250 ? 308 LEU   A O   1 
ATOM   1055 C CB  . LEU   A 1 190 ? 19.16483  68.90523 -6.37878  1.000 33.71926 ? 308 LEU   A CB  1 
ATOM   1056 C CG  . LEU   A 1 190 ? 17.93811  68.82863 -5.48009  1.000 29.53942 ? 308 LEU   A CG  1 
ATOM   1057 C CD1 . LEU   A 1 190 ? 17.97452  67.58449 -4.57122  1.000 38.51260 ? 308 LEU   A CD1 1 
ATOM   1058 C CD2 . LEU   A 1 190 ? 17.86833  70.11460 -4.70739  1.000 28.17115 ? 308 LEU   A CD2 1 
ATOM   1059 N N   . GLU   A 1 191 ? 20.72832  71.11358 -8.45099  1.000 47.02354 ? 309 GLU   A N   1 
ATOM   1060 C CA  . GLU   A 1 191 ? 21.96070  71.38504 -9.17066  1.000 53.24747 ? 309 GLU   A CA  1 
ATOM   1061 C C   . GLU   A 1 191 ? 23.15661  70.96141 -8.32980  1.000 52.07130 ? 309 GLU   A C   1 
ATOM   1062 O O   . GLU   A 1 191 ? 23.20229  71.22338 -7.12630  1.000 55.24586 ? 309 GLU   A O   1 
ATOM   1063 C CB  . GLU   A 1 191 ? 22.05174  72.87359 -9.51107  1.000 55.23858 ? 309 GLU   A CB  1 
ATOM   1064 C CG  . GLU   A 1 191 ? 21.02966  73.34818 -10.54423 1.000 51.92841 ? 309 GLU   A CG  1 
ATOM   1065 C CD  . GLU   A 1 191 ? 21.29311  72.78021 -11.93993 1.000 60.51194 ? 309 GLU   A CD  1 
ATOM   1066 O OE1 . GLU   A 1 191 ? 20.88702  71.62221 -12.21408 1.000 59.40146 ? 309 GLU   A OE1 1 
ATOM   1067 O OE2 . GLU   A 1 191 ? 21.90475  73.49334 -12.76018 1.000 52.07982 ? 309 GLU   A OE2 1 
ATOM   1068 N N   . ASP   A 1 192 ? 24.12238  70.30297 -8.96778  1.000 59.68357 ? 310 ASP   A N   1 
ATOM   1069 C CA  . ASP   A 1 192 ? 25.34826  69.86957 -8.28807  1.000 61.73660 ? 310 ASP   A CA  1 
ATOM   1070 C C   . ASP   A 1 192 ? 26.13347  71.05762 -7.72901  1.000 63.61674 ? 310 ASP   A C   1 
ATOM   1071 O O   . ASP   A 1 192 ? 26.72267  70.97460 -6.64816  1.000 64.17341 ? 310 ASP   A O   1 
ATOM   1072 C CB  . ASP   A 1 192 ? 26.23513  69.06157 -9.24119  1.000 61.66381 ? 310 ASP   A CB  1 
ATOM   1073 N N   . PHE   A 1 197 ? 27.58915  67.28817 -3.14260  1.000 68.56576 ? 315 PHE   A N   1 
ATOM   1074 C CA  . PHE   A 1 197 ? 26.87221  66.02956 -2.96435  1.000 70.47190 ? 315 PHE   A CA  1 
ATOM   1075 C C   . PHE   A 1 197 ? 26.39847  65.87261 -1.52360  1.000 71.23077 ? 315 PHE   A C   1 
ATOM   1076 O O   . PHE   A 1 197 ? 25.27007  66.22934 -1.19418  1.000 73.94771 ? 315 PHE   A O   1 
ATOM   1077 C CB  . PHE   A 1 197 ? 27.75453  64.84721 -3.36165  1.000 65.50766 ? 315 PHE   A CB  1 
ATOM   1078 N N   . GLN   A 1 198 ? 27.26347  65.33020 -0.66231  1.000 71.74141 ? 316 GLN   A N   1 
ATOM   1079 C CA  . GLN   A 1 198 ? 26.92877  65.24392 0.75482   1.000 66.83662 ? 316 GLN   A CA  1 
ATOM   1080 C C   . GLN   A 1 198 ? 26.72745  66.62310 1.36984   1.000 67.07549 ? 316 GLN   A C   1 
ATOM   1081 O O   . GLN   A 1 198 ? 26.03839  66.73989 2.38946   1.000 67.60740 ? 316 GLN   A O   1 
ATOM   1082 C CB  . GLN   A 1 198 ? 28.01480  64.46969 1.50975   1.000 69.34861 ? 316 GLN   A CB  1 
ATOM   1083 N N   . GLN   A 1 199 ? 27.29865  67.67085 0.76260   1.000 66.25658 ? 317 GLN   A N   1 
ATOM   1084 C CA  . GLN   A 1 199 ? 26.97543  69.03972 1.15406   1.000 65.79428 ? 317 GLN   A CA  1 
ATOM   1085 C C   . GLN   A 1 199 ? 25.48662  69.33931 1.01525   1.000 64.16247 ? 317 GLN   A C   1 
ATOM   1086 O O   . GLN   A 1 199 ? 24.97886  70.23603 1.69901   1.000 67.40721 ? 317 GLN   A O   1 
ATOM   1087 C CB  . GLN   A 1 199 ? 27.79018  70.03153 0.31598   1.000 66.96248 ? 317 GLN   A CB  1 
ATOM   1088 N N   . LEU   A 1 200 ? 24.77920  68.60221 0.15121   1.000 65.38418 ? 318 LEU   A N   1 
ATOM   1089 C CA  . LEU   A 1 200 ? 23.34025  68.79363 -0.00854  1.000 62.11016 ? 318 LEU   A CA  1 
ATOM   1090 C C   . LEU   A 1 200 ? 22.57726  68.31884 1.22264   1.000 52.92104 ? 318 LEU   A C   1 
ATOM   1091 O O   . LEU   A 1 200 ? 21.70493  69.03229 1.73407   1.000 55.62499 ? 318 LEU   A O   1 
ATOM   1092 C CB  . LEU   A 1 200 ? 22.85319  68.06252 -1.25915  1.000 58.78486 ? 318 LEU   A CB  1 
ATOM   1093 N N   . LEU   A 1 201 ? 22.89233  67.11723 1.71665   1.000 55.65429 ? 319 LEU   A N   1 
ATOM   1094 C CA  . LEU   A 1 201 ? 22.21147  66.56249 2.88347   1.000 52.31463 ? 319 LEU   A CA  1 
ATOM   1095 C C   . LEU   A 1 201 ? 22.46496  67.35457 4.16151   1.000 52.72232 ? 319 LEU   A C   1 
ATOM   1096 O O   . LEU   A 1 201 ? 21.87791  67.05259 5.20875   1.000 50.41295 ? 319 LEU   A O   1 
ATOM   1097 C CB  . LEU   A 1 201 ? 22.61244  65.10283 3.10458   1.000 56.35326 ? 319 LEU   A CB  1 
ATOM   1098 C CG  . LEU   A 1 201 ? 21.76011  64.03326 2.41715   1.000 55.69664 ? 319 LEU   A CG  1 
ATOM   1099 C CD1 . LEU   A 1 201 ? 21.82773  64.15319 0.90082   1.000 60.64552 ? 319 LEU   A CD1 1 
ATOM   1100 C CD2 . LEU   A 1 201 ? 22.19073  62.64408 2.88168   1.000 61.01773 ? 319 LEU   A CD2 1 
ATOM   1101 N N   . LEU   A 1 202 ? 23.33476  68.36167 4.10311   1.000 46.68288 ? 320 LEU   A N   1 
ATOM   1102 C CA  . LEU   A 1 202 ? 23.44220  69.26336 5.24295   1.000 46.30243 ? 320 LEU   A CA  1 
ATOM   1103 C C   . LEU   A 1 202 ? 22.22128  70.15216 5.36201   1.000 48.71852 ? 320 LEU   A C   1 
ATOM   1104 O O   . LEU   A 1 202 ? 21.92391  70.63273 6.45827   1.000 44.65426 ? 320 LEU   A O   1 
ATOM   1105 C CB  . LEU   A 1 202 ? 24.70537  70.11975 5.13925   1.000 51.66283 ? 320 LEU   A CB  1 
ATOM   1106 C CG  . LEU   A 1 202 ? 25.97197  69.54427 5.78156   1.000 52.24234 ? 320 LEU   A CG  1 
ATOM   1107 C CD1 . LEU   A 1 202 ? 26.39292  68.24834 5.13409   1.000 56.14121 ? 320 LEU   A CD1 1 
ATOM   1108 C CD2 . LEU   A 1 202 ? 27.10674  70.56338 5.70385   1.000 57.27464 ? 320 LEU   A CD2 1 
ATOM   1109 N N   . GLU   A 1 203 ? 21.51871  70.38361 4.26561   1.000 42.18719 ? 321 GLU   A N   1 
ATOM   1110 C CA  . GLU   A 1 203 ? 20.26105  71.10711 4.33271   1.000 42.82452 ? 321 GLU   A CA  1 
ATOM   1111 C C   . GLU   A 1 203 ? 19.21867  70.21618 4.99336   1.000 33.80444 ? 321 GLU   A C   1 
ATOM   1112 O O   . GLU   A 1 203 ? 18.91276  69.13905 4.46292   1.000 34.92210 ? 321 GLU   A O   1 
ATOM   1113 C CB  . GLU   A 1 203 ? 19.81233  71.52822 2.93548   1.000 41.16525 ? 321 GLU   A CB  1 
ATOM   1114 C CG  . GLU   A 1 203 ? 18.70527  72.55238 2.96362   1.000 44.52448 ? 321 GLU   A CG  1 
ATOM   1115 C CD  . GLU   A 1 203 ? 19.10236  73.79387 3.73322   1.000 47.87527 ? 321 GLU   A CD  1 
ATOM   1116 O OE1 . GLU   A 1 203 ? 20.16640  74.37216 3.42884   1.000 55.08265 ? 321 GLU   A OE1 1 
ATOM   1117 O OE2 . GLU   A 1 203 ? 18.34960  74.18554 4.65115   1.000 54.21060 ? 321 GLU   A OE2 1 
ATOM   1118 N N   . PRO   A 1 204 ? 18.65654  70.60803 6.13818   1.000 31.36776 ? 322 PRO   A N   1 
ATOM   1119 C CA  . PRO   A 1 204 ? 17.74995  69.68912 6.85361   1.000 35.80536 ? 322 PRO   A CA  1 
ATOM   1120 C C   . PRO   A 1 204 ? 16.53787  69.24371 6.04128   1.000 31.33572 ? 322 PRO   A C   1 
ATOM   1121 O O   . PRO   A 1 204 ? 16.19205  68.05921 6.07803   1.000 33.76152 ? 322 PRO   A O   1 
ATOM   1122 C CB  . PRO   A 1 204 ? 17.34789  70.50031 8.09046   1.000 42.28144 ? 322 PRO   A CB  1 
ATOM   1123 C CG  . PRO   A 1 204 ? 18.51622  71.45628 8.29657   1.000 41.64028 ? 322 PRO   A CG  1 
ATOM   1124 C CD  . PRO   A 1 204 ? 18.93933  71.83097 6.90591   1.000 41.73676 ? 322 PRO   A CD  1 
ATOM   1125 N N   . MET   A 1 205 ? 15.88291  70.14336 5.30378   1.000 35.22740 ? 323 MET   A N   1 
ATOM   1126 C CA  . MET   A 1 205 ? 14.74293  69.71568 4.49294   1.000 32.98057 ? 323 MET   A CA  1 
ATOM   1127 C C   . MET   A 1 205 ? 15.15927  68.75186 3.39934   1.000 26.72184 ? 323 MET   A C   1 
ATOM   1128 O O   . MET   A 1 205 ? 14.39223  67.85093 3.04552   1.000 28.40858 ? 323 MET   A O   1 
ATOM   1129 C CB  . MET   A 1 205 ? 14.01839  70.92014 3.89253   1.000 37.51264 ? 323 MET   A CB  1 
ATOM   1130 C CG  . MET   A 1 205 ? 12.58574  70.62390 3.42210   1.000 36.33196 ? 323 MET   A CG  1 
ATOM   1131 S SD  . MET   A 1 205 ? 11.49472  70.06745 4.76555   1.000 41.31925 ? 323 MET   A SD  1 
ATOM   1132 C CE  . MET   A 1 205 ? 11.10954  68.44032 4.19188   1.000 32.42307 ? 323 MET   A CE  1 
ATOM   1133 N N   . LEU   A 1 206 ? 16.36697  68.90772 2.86127   1.000 29.57610 ? 324 LEU   A N   1 
ATOM   1134 C CA  A LEU   A 1 206 ? 16.83138  68.00080 1.81865   0.543 31.10466 ? 324 LEU   A CA  1 
ATOM   1135 C CA  B LEU   A 1 206 ? 16.81284  67.99573 1.81839   0.457 31.06139 ? 324 LEU   A CA  1 
ATOM   1136 C C   . LEU   A 1 206 ? 17.11595  66.61702 2.38467   1.000 30.28092 ? 324 LEU   A C   1 
ATOM   1137 O O   . LEU   A 1 206 ? 16.72671  65.59902 1.79535   1.000 32.56459 ? 324 LEU   A O   1 
ATOM   1138 C CB  A LEU   A 1 206 ? 18.07786  68.57020 1.14368   0.543 33.02711 ? 324 LEU   A CB  1 
ATOM   1139 C CB  B LEU   A 1 206 ? 18.03552  68.56219 1.10886   0.457 33.27151 ? 324 LEU   A CB  1 
ATOM   1140 C CG  A LEU   A 1 206 ? 17.83326  69.58305 0.02432   0.543 33.86532 ? 324 LEU   A CG  1 
ATOM   1141 C CG  B LEU   A 1 206 ? 18.47328  67.71694 -0.08016  0.457 34.07044 ? 324 LEU   A CG  1 
ATOM   1142 C CD1 A LEU   A 1 206 ? 19.10344  69.78519 -0.79338  0.543 37.34298 ? 324 LEU   A CD1 1 
ATOM   1143 C CD1 B LEU   A 1 206 ? 17.29078  67.45304 -1.00669  0.457 34.15967 ? 324 LEU   A CD1 1 
ATOM   1144 C CD2 A LEU   A 1 206 ? 16.67137  69.13324 -0.86216  0.543 32.37110 ? 324 LEU   A CD2 1 
ATOM   1145 C CD2 B LEU   A 1 206 ? 19.54737  68.45069 -0.82444  0.457 36.77439 ? 324 LEU   A CD2 1 
ATOM   1146 N N   . LYS   A 1 207 ? 17.81733  66.56232 3.51913   1.000 33.21036 ? 325 LYS   A N   1 
ATOM   1147 C CA  . LYS   A 1 207 ? 18.05790  65.28183 4.17402   1.000 33.14392 ? 325 LYS   A CA  1 
ATOM   1148 C C   . LYS   A 1 207 ? 16.73982  64.63504 4.57419   1.000 29.67454 ? 325 LYS   A C   1 
ATOM   1149 O O   . LYS   A 1 207 ? 16.57551  63.41623 4.44897   1.000 30.57500 ? 325 LYS   A O   1 
ATOM   1150 C CB  . LYS   A 1 207 ? 18.96007  65.48571 5.39364   1.000 35.62377 ? 325 LYS   A CB  1 
ATOM   1151 C CG  . LYS   A 1 207 ? 19.22957  64.23981 6.20586   1.000 37.70954 ? 325 LYS   A CG  1 
ATOM   1152 C CD  . LYS   A 1 207 ? 19.82300  64.59884 7.56928   1.000 47.80290 ? 325 LYS   A CD  1 
ATOM   1153 N N   . PHE   A 1 208 ? 15.77058  65.44327 5.02521   1.000 30.48669 ? 326 PHE   A N   1 
ATOM   1154 C CA  . PHE   A 1 208 ? 14.44461  64.89727 5.32814   1.000 29.09215 ? 326 PHE   A CA  1 
ATOM   1155 C C   . PHE   A 1 208 ? 13.84820  64.16906 4.12038   1.000 25.54981 ? 326 PHE   A C   1 
ATOM   1156 O O   . PHE   A 1 208 ? 13.36695  63.03416 4.25046   1.000 24.63917 ? 326 PHE   A O   1 
ATOM   1157 C CB  . PHE   A 1 208 ? 13.50590  66.00252 5.80941   1.000 30.36884 ? 326 PHE   A CB  1 
ATOM   1158 C CG  . PHE   A 1 208 ? 12.12358  65.50762 6.15531   1.000 29.76106 ? 326 PHE   A CG  1 
ATOM   1159 C CD1 . PHE   A 1 208 ? 11.16346  65.33227 5.16536   1.000 31.09966 ? 326 PHE   A CD1 1 
ATOM   1160 C CD2 . PHE   A 1 208 ? 11.78782  65.21887 7.46486   1.000 35.04888 ? 326 PHE   A CD2 1 
ATOM   1161 C CE1 . PHE   A 1 208 ? 9.89167   64.87631 5.47048   1.000 30.86914 ? 326 PHE   A CE1 1 
ATOM   1162 C CE2 . PHE   A 1 208 ? 10.51045  64.76690 7.78138   1.000 32.89676 ? 326 PHE   A CE2 1 
ATOM   1163 C CZ  . PHE   A 1 208 ? 9.57136   64.59425 6.78103   1.000 29.65664 ? 326 PHE   A CZ  1 
ATOM   1164 N N   . HIS   A 1 209 ? 13.87048  64.80153 2.92917   1.000 24.45707 ? 327 HIS   A N   1 
ATOM   1165 C CA  . HIS   A 1 209 ? 13.28801  64.15467 1.74976   1.000 27.29455 ? 327 HIS   A CA  1 
ATOM   1166 C C   . HIS   A 1 209 ? 13.99517  62.83727 1.42320   1.000 27.80930 ? 327 HIS   A C   1 
ATOM   1167 O O   . HIS   A 1 209 ? 13.33980  61.82728 1.12156   1.000 24.92104 ? 327 HIS   A O   1 
ATOM   1168 C CB  . HIS   A 1 209 ? 13.30991  65.10102 0.53251   1.000 24.81828 ? 327 HIS   A CB  1 
ATOM   1169 C CG  . HIS   A 1 209 ? 12.11897  66.01547 0.46253   1.000 24.51255 ? 327 HIS   A CG  1 
ATOM   1170 N ND1 . HIS   A 1 209 ? 10.88033  65.59797 0.02247   1.000 26.35009 ? 327 HIS   A ND1 1 
ATOM   1171 C CD2 . HIS   A 1 209 ? 11.97202  67.31491 0.81244   1.000 23.56924 ? 327 HIS   A CD2 1 
ATOM   1172 C CE1 . HIS   A 1 209 ? 10.02399  66.60242 0.09969   1.000 26.14377 ? 327 HIS   A CE1 1 
ATOM   1173 N NE2 . HIS   A 1 209 ? 10.66156  67.65647 0.57477   1.000 26.78827 ? 327 HIS   A NE2 1 
ATOM   1174 N N   . TYR   A 1 210 ? 15.33211  62.81720 1.48252   1.000 25.12640 ? 328 TYR   A N   1 
ATOM   1175 C CA  . TYR   A 1 210 ? 16.05379  61.57673 1.19503   1.000 28.14081 ? 328 TYR   A CA  1 
ATOM   1176 C C   . TYR   A 1 210 ? 15.77932  60.50458 2.24852   1.000 23.01670 ? 328 TYR   A C   1 
ATOM   1177 O O   . TYR   A 1 210 ? 15.58595  59.33435 1.91093   1.000 26.33673 ? 328 TYR   A O   1 
ATOM   1178 C CB  . TYR   A 1 210 ? 17.55579  61.83628 1.11953   1.000 28.50144 ? 328 TYR   A CB  1 
ATOM   1179 C CG  . TYR   A 1 210 ? 17.98054  62.35545 -0.21083  1.000 31.17056 ? 328 TYR   A CG  1 
ATOM   1180 C CD1 . TYR   A 1 210 ? 18.07110  61.51338 -1.30570  1.000 29.20222 ? 328 TYR   A CD1 1 
ATOM   1181 C CD2 . TYR   A 1 210 ? 18.27967  63.69958 -0.38131  1.000 33.11745 ? 328 TYR   A CD2 1 
ATOM   1182 C CE1 . TYR   A 1 210 ? 18.45772  62.00189 -2.54280  1.000 32.74316 ? 328 TYR   A CE1 1 
ATOM   1183 C CE2 . TYR   A 1 210 ? 18.66399  64.19044 -1.60118  1.000 33.62292 ? 328 TYR   A CE2 1 
ATOM   1184 C CZ  . TYR   A 1 210 ? 18.74620  63.34453 -2.67813  1.000 31.35890 ? 328 TYR   A CZ  1 
ATOM   1185 O OH  . TYR   A 1 210 ? 19.12661  63.84900 -3.90279  1.000 36.28263 ? 328 TYR   A OH  1 
ATOM   1186 N N   . MET   A 1 211 ? 15.80806  60.87762 3.52388   1.000 25.57281 ? 329 MET   A N   1 
ATOM   1187 C CA  . MET   A 1 211 ? 15.57445  59.89896 4.57775   1.000 28.78993 ? 329 MET   A CA  1 
ATOM   1188 C C   . MET   A 1 211 ? 14.15715  59.34634 4.51804   1.000 29.10581 ? 329 MET   A C   1 
ATOM   1189 O O   . MET   A 1 211 ? 13.95600  58.13833 4.66086   1.000 25.41062 ? 329 MET   A O   1 
ATOM   1190 C CB  . MET   A 1 211 ? 15.84592  60.51884 5.94244   1.000 28.63172 ? 329 MET   A CB  1 
ATOM   1191 C CG  . MET   A 1 211 ? 17.33493  60.66356 6.25643   1.000 35.82369 ? 329 MET   A CG  1 
ATOM   1192 S SD  . MET   A 1 211 ? 17.53261  61.60362 7.78479   1.000 61.68751 ? 329 MET   A SD  1 
ATOM   1193 C CE  . MET   A 1 211 ? 16.56518  60.61033 8.91305   1.000 43.79181 ? 329 MET   A CE  1 
ATOM   1194 N N   . LEU   A 1 212 ? 13.15600  60.20773 4.30298   1.000 25.30995 ? 330 LEU   A N   1 
ATOM   1195 C CA  . LEU   A 1 212 ? 11.78570  59.70307 4.21911   1.000 25.35692 ? 330 LEU   A CA  1 
ATOM   1196 C C   . LEU   A 1 212 ? 11.59354  58.81325 2.98609   1.000 25.81745 ? 330 LEU   A C   1 
ATOM   1197 O O   . LEU   A 1 212 ? 10.95761  57.75397 3.06482   1.000 24.55272 ? 330 LEU   A O   1 
ATOM   1198 C CB  . LEU   A 1 212 ? 10.79958  60.87479 4.22313   1.000 24.00614 ? 330 LEU   A CB  1 
ATOM   1199 C CG  . LEU   A 1 212 ? 9.31317   60.50393 4.18529   1.000 26.14118 ? 330 LEU   A CG  1 
ATOM   1200 C CD1 . LEU   A 1 212 ? 8.93674   59.64701 5.43020   1.000 23.29691 ? 330 LEU   A CD1 1 
ATOM   1201 C CD2 . LEU   A 1 212 ? 8.46655   61.77288 4.12871   1.000 22.58182 ? 330 LEU   A CD2 1 
ATOM   1202 N N   . LYS   A 1 213 ? 12.15876  59.20529 1.84256   1.000 23.62593 ? 331 LYS   A N   1 
ATOM   1203 C CA  . LYS   A 1 213 ? 12.05096  58.36649 0.64959   1.000 23.85686 ? 331 LYS   A CA  1 
ATOM   1204 C C   . LYS   A 1 213 ? 12.61382  56.96399 0.88711   1.000 28.17989 ? 331 LYS   A C   1 
ATOM   1205 O O   . LYS   A 1 213 ? 12.09316  55.98381 0.35167   1.000 25.20212 ? 331 LYS   A O   1 
ATOM   1206 C CB  . LYS   A 1 213 ? 12.77302  59.01745 -0.53186  1.000 25.05665 ? 331 LYS   A CB  1 
ATOM   1207 C CG  . LYS   A 1 213 ? 12.35302  58.43250 -1.85395  1.000 33.22367 ? 331 LYS   A CG  1 
ATOM   1208 C CD  . LYS   A 1 213 ? 11.00126  58.97471 -2.27604  1.000 24.77212 ? 331 LYS   A CD  1 
ATOM   1209 C CE  . LYS   A 1 213 ? 10.48621  58.23311 -3.49969  1.000 29.60204 ? 331 LYS   A CE  1 
ATOM   1210 N NZ  . LYS   A 1 213 ? 9.25544   58.87246 -4.01540  1.000 26.75910 ? 331 LYS   A NZ  1 
ATOM   1211 N N   . LYS   A 1 214 ? 13.67442  56.84928 1.69086   1.000 28.59250 ? 332 LYS   A N   1 
ATOM   1212 C CA  . LYS   A 1 214 ? 14.29091  55.54684 1.94380   1.000 34.38054 ? 332 LYS   A CA  1 
ATOM   1213 C C   . LYS   A 1 214 ? 13.40534  54.62558 2.77629   1.000 34.38784 ? 332 LYS   A C   1 
ATOM   1214 O O   . LYS   A 1 214 ? 13.59432  53.40900 2.74106   1.000 34.19303 ? 332 LYS   A O   1 
ATOM   1215 C CB  . LYS   A 1 214 ? 15.63386  55.72506 2.65980   1.000 35.26645 ? 332 LYS   A CB  1 
ATOM   1216 C CG  . LYS   A 1 214 ? 16.79093  54.94864 2.04979   1.000 48.54163 ? 332 LYS   A CG  1 
ATOM   1217 C CD  . LYS   A 1 214 ? 18.10709  55.33920 2.72638   1.000 46.43165 ? 332 LYS   A CD  1 
ATOM   1218 N N   . LEU   A 1 215 ? 12.46103  55.16758 3.54355   1.000 30.48106 ? 333 LEU   A N   1 
ATOM   1219 C CA  . LEU   A 1 215 ? 11.55534  54.29341 4.26812   1.000 30.67521 ? 333 LEU   A CA  1 
ATOM   1220 C C   . LEU   A 1 215 ? 10.60589  53.53393 3.34492   1.000 29.75892 ? 333 LEU   A C   1 
ATOM   1221 O O   . LEU   A 1 215 ? 9.96690   52.57724 3.79859   1.000 32.54863 ? 333 LEU   A O   1 
ATOM   1222 C CB  . LEU   A 1 215 ? 10.77250  55.11133 5.28890   1.000 28.34709 ? 333 LEU   A CB  1 
ATOM   1223 C CG  . LEU   A 1 215 ? 11.62196  55.84857 6.32484   1.000 30.26046 ? 333 LEU   A CG  1 
ATOM   1224 C CD1 . LEU   A 1 215 ? 10.73407  56.64426 7.26611   1.000 30.69356 ? 333 LEU   A CD1 1 
ATOM   1225 C CD2 . LEU   A 1 215 ? 12.54606  54.88316 7.09760   1.000 34.17180 ? 333 LEU   A CD2 1 
ATOM   1226 N N   . GLN   A 1 216 ? 10.49785  53.92245 2.06936   1.000 26.85770 ? 334 GLN   A N   1 
ATOM   1227 C CA  . GLN   A 1 216 ? 9.64080   53.21473 1.11061   1.000 28.46031 ? 334 GLN   A CA  1 
ATOM   1228 C C   . GLN   A 1 216 ? 8.21912   53.02846 1.64656   1.000 24.26517 ? 334 GLN   A C   1 
ATOM   1229 O O   . GLN   A 1 216 ? 7.68485   51.91829 1.69300   1.000 28.53825 ? 334 GLN   A O   1 
ATOM   1230 C CB  . GLN   A 1 216 ? 10.25184  51.86280 0.72742   1.000 37.36671 ? 334 GLN   A CB  1 
ATOM   1231 C CG  . GLN   A 1 216 ? 11.52572  51.93946 -0.11546  1.000 41.52061 ? 334 GLN   A CG  1 
ATOM   1232 C CD  . GLN   A 1 216 ? 12.04749  50.55093 -0.46771  1.000 54.04645 ? 334 GLN   A CD  1 
ATOM   1233 O OE1 . GLN   A 1 216 ? 11.47853  49.85522 -1.30991  1.000 54.82375 ? 334 GLN   A OE1 1 
ATOM   1234 N NE2 . GLN   A 1 216 ? 13.10730  50.12649 0.21227   1.000 52.87116 ? 334 GLN   A NE2 1 
ATOM   1235 N N   . LEU   A 1 217 ? 7.59373   54.13312 2.04563   1.000 24.04275 ? 335 LEU   A N   1 
ATOM   1236 C CA  . LEU   A 1 217 ? 6.26242   54.06672 2.63165   1.000 22.02328 ? 335 LEU   A CA  1 
ATOM   1237 C C   . LEU   A 1 217 ? 5.18412   53.79730 1.58666   1.000 26.77075 ? 335 LEU   A C   1 
ATOM   1238 O O   . LEU   A 1 217 ? 5.31984   54.14124 0.40814   1.000 25.38736 ? 335 LEU   A O   1 
ATOM   1239 C CB  . LEU   A 1 217 ? 5.92130   55.37320 3.35297   1.000 24.31012 ? 335 LEU   A CB  1 
ATOM   1240 C CG  . LEU   A 1 217 ? 6.86610   55.80660 4.47483   1.000 26.10364 ? 335 LEU   A CG  1 
ATOM   1241 C CD1 . LEU   A 1 217 ? 6.29411   57.01778 5.17868   1.000 27.15175 ? 335 LEU   A CD1 1 
ATOM   1242 C CD2 . LEU   A 1 217 ? 7.06666   54.65960 5.45896   1.000 28.78197 ? 335 LEU   A CD2 1 
ATOM   1243 N N   . HIS   A 1 218 ? 4.08860   53.20081 2.05260   1.000 26.62227 ? 336 HIS   A N   1 
ATOM   1244 C CA  . HIS   A 1 218 ? 2.87039   53.02153 1.27508   1.000 30.00611 ? 336 HIS   A CA  1 
ATOM   1245 C C   . HIS   A 1 218 ? 2.11346   54.34305 1.16353   1.000 29.05811 ? 336 HIS   A C   1 
ATOM   1246 O O   . HIS   A 1 218 ? 2.31065   55.26814 1.96748   1.000 24.01562 ? 336 HIS   A O   1 
ATOM   1247 C CB  . HIS   A 1 218 ? 1.95982   51.98732 1.94931   1.000 25.11525 ? 336 HIS   A CB  1 
ATOM   1248 C CG  . HIS   A 1 218 ? 2.54904   50.61716 2.01854   1.000 34.60608 ? 336 HIS   A CG  1 
ATOM   1249 N ND1 . HIS   A 1 218 ? 1.90588   49.56256 2.63140   1.000 33.43588 ? 336 HIS   A ND1 1 
ATOM   1250 C CD2 . HIS   A 1 218 ? 3.71727   50.12444 1.54106   1.000 34.92055 ? 336 HIS   A CD2 1 
ATOM   1251 C CE1 . HIS   A 1 218 ? 2.65545   48.47858 2.52645   1.000 35.67191 ? 336 HIS   A CE1 1 
ATOM   1252 N NE2 . HIS   A 1 218 ? 3.75859   48.79342 1.87174   1.000 37.66135 ? 336 HIS   A NE2 1 
ATOM   1253 N N   . GLU   A 1 219 ? 1.20878   54.41648 0.17506   1.000 24.42365 ? 337 GLU   A N   1 
ATOM   1254 C CA  . GLU   A 1 219 ? 0.32803   55.57820 0.08540   1.000 26.27164 ? 337 GLU   A CA  1 
ATOM   1255 C C   . GLU   A 1 219 ? -0.41704  55.78039 1.39565   1.000 24.96409 ? 337 GLU   A C   1 
ATOM   1256 O O   . GLU   A 1 219 ? -0.56756  56.91105 1.86592   1.000 23.56156 ? 337 GLU   A O   1 
ATOM   1257 C CB  . GLU   A 1 219 ? -0.67697  55.42576 -1.06530  1.000 28.54105 ? 337 GLU   A CB  1 
ATOM   1258 C CG  . GLU   A 1 219 ? -0.06177  55.28121 -2.48209  1.000 28.18638 ? 337 GLU   A CG  1 
ATOM   1259 C CD  . GLU   A 1 219 ? 0.36006   56.61719 -3.10723  1.000 31.65567 ? 337 GLU   A CD  1 
ATOM   1260 O OE1 . GLU   A 1 219 ? 0.28038   57.67850 -2.43876  1.000 25.99545 ? 337 GLU   A OE1 1 
ATOM   1261 O OE2 . GLU   A 1 219 ? 0.78156   56.59620 -4.28139  1.000 33.58539 ? 337 GLU   A OE2 1 
ATOM   1262 N N   . GLU   A 1 220 ? -0.90162  54.68607 1.98827   1.000 22.30693 ? 338 GLU   A N   1 
ATOM   1263 C CA  . GLU   A 1 220 ? -1.64572  54.76033 3.24115   1.000 25.27883 ? 338 GLU   A CA  1 
ATOM   1264 C C   . GLU   A 1 220 ? -0.80627  55.35581 4.36949   1.000 25.50085 ? 338 GLU   A C   1 
ATOM   1265 O O   . GLU   A 1 220 ? -1.33032  56.07666 5.22618   1.000 23.34437 ? 338 GLU   A O   1 
ATOM   1266 C CB  . GLU   A 1 220 ? -2.14122  53.36603 3.62579   1.000 29.38558 ? 338 GLU   A CB  1 
ATOM   1267 C CG  . GLU   A 1 220 ? -3.25466  52.81611 2.72627   1.000 25.22846 ? 338 GLU   A CG  1 
ATOM   1268 C CD  . GLU   A 1 220 ? -2.73176  52.13921 1.44979   1.000 29.56437 ? 338 GLU   A CD  1 
ATOM   1269 O OE1 . GLU   A 1 220 ? -1.54699  52.30762 1.09707   1.000 27.04760 ? 338 GLU   A OE1 1 
ATOM   1270 O OE2 . GLU   A 1 220 ? -3.51423  51.43833 0.79210   1.000 30.59932 ? 338 GLU   A OE2 1 
ATOM   1271 N N   . GLU   A 1 221 ? 0.49262   55.04621 4.40871   1.000 26.51549 ? 339 GLU   A N   1 
ATOM   1272 C CA  . GLU   A 1 221 ? 1.33003   55.57759 5.48367   1.000 23.85580 ? 339 GLU   A CA  1 
ATOM   1273 C C   . GLU   A 1 221 ? 1.58836   57.07280 5.29348   1.000 23.97878 ? 339 GLU   A C   1 
ATOM   1274 O O   . GLU   A 1 221 ? 1.58055   57.83845 6.26556   1.000 21.58617 ? 339 GLU   A O   1 
ATOM   1275 C CB  . GLU   A 1 221 ? 2.63656   54.77493 5.55918   1.000 23.34095 ? 339 GLU   A CB  1 
ATOM   1276 C CG  . GLU   A 1 221 ? 2.40536   53.33708 6.06851   1.000 28.24538 ? 339 GLU   A CG  1 
ATOM   1277 C CD  . GLU   A 1 221 ? 3.49789   52.35434 5.68604   1.000 32.22235 ? 339 GLU   A CD  1 
ATOM   1278 O OE1 . GLU   A 1 221 ? 4.25723   52.60461 4.71438   1.000 27.86527 ? 339 GLU   A OE1 1 
ATOM   1279 O OE2 . GLU   A 1 221 ? 3.58682   51.31303 6.36559   1.000 31.32149 ? 339 GLU   A OE2 1 
ATOM   1280 N N   . TYR   A 1 222 ? 1.78098   57.51636 4.04165   1.000 20.87611 ? 340 TYR   A N   1 
ATOM   1281 C CA  . TYR   A 1 222 ? 1.90588   58.94771 3.78576   1.000 22.68421 ? 340 TYR   A CA  1 
ATOM   1282 C C   . TYR   A 1 222 ? 0.64444   59.69440 4.19391   1.000 21.36445 ? 340 TYR   A C   1 
ATOM   1283 O O   . TYR   A 1 222 ? 0.72539   60.77847 4.77919   1.000 21.15476 ? 340 TYR   A O   1 
ATOM   1284 C CB  . TYR   A 1 222 ? 2.19407   59.22411 2.30511   1.000 20.43180 ? 340 TYR   A CB  1 
ATOM   1285 C CG  . TYR   A 1 222 ? 3.63590   59.10625 1.86566   1.000 22.84740 ? 340 TYR   A CG  1 
ATOM   1286 C CD1 . TYR   A 1 222 ? 4.56263   60.11823 2.14536   1.000 19.10556 ? 340 TYR   A CD1 1 
ATOM   1287 C CD2 . TYR   A 1 222 ? 4.06249   57.99745 1.12616   1.000 18.63315 ? 340 TYR   A CD2 1 
ATOM   1288 C CE1 . TYR   A 1 222 ? 5.87499   60.00506 1.72802   1.000 22.47541 ? 340 TYR   A CE1 1 
ATOM   1289 C CE2 . TYR   A 1 222 ? 5.36099   57.88942 0.70324   1.000 22.77069 ? 340 TYR   A CE2 1 
ATOM   1290 C CZ  . TYR   A 1 222 ? 6.26734   58.89753 1.00598   1.000 17.83949 ? 340 TYR   A CZ  1 
ATOM   1291 O OH  . TYR   A 1 222 ? 7.56628   58.78752 0.56023   1.000 23.22708 ? 340 TYR   A OH  1 
ATOM   1292 N N   . VAL   A 1 223 ? -0.53484  59.15477 3.87297   1.000 19.16789 ? 341 VAL   A N   1 
ATOM   1293 C CA  . VAL   A 1 223 ? -1.72203  59.94113 4.16829   1.000 21.00427 ? 341 VAL   A CA  1 
ATOM   1294 C C   . VAL   A 1 223 ? -1.97299  59.97352 5.67949   1.000 21.65620 ? 341 VAL   A C   1 
ATOM   1295 O O   . VAL   A 1 223 ? -2.51240  60.95043 6.19451   1.000 20.60135 ? 341 VAL   A O   1 
ATOM   1296 C CB  . VAL   A 1 223 ? -2.94817  59.43278 3.38221   1.000 26.17994 ? 341 VAL   A CB  1 
ATOM   1297 C CG1 . VAL   A 1 223 ? -3.52848  58.18357 4.00556   1.000 22.43752 ? 341 VAL   A CG1 1 
ATOM   1298 C CG2 . VAL   A 1 223 ? -3.99475  60.52362 3.27396   1.000 28.65276 ? 341 VAL   A CG2 1 
ATOM   1299 N N   . LEU   A 1 224 ? -1.57783  58.92499 6.41309   1.000 22.14668 ? 342 LEU   A N   1 
ATOM   1300 C CA  . LEU   A 1 224 ? -1.66309  58.98930 7.87167   1.000 23.22944 ? 342 LEU   A CA  1 
ATOM   1301 C C   . LEU   A 1 224 ? -0.66553  59.99614 8.44082   1.000 22.46742 ? 342 LEU   A C   1 
ATOM   1302 O O   . LEU   A 1 224 ? -0.98883  60.72467 9.38642   1.000 21.22840 ? 342 LEU   A O   1 
ATOM   1303 C CB  . LEU   A 1 224 ? -1.43379  57.60499 8.47038   1.000 23.07969 ? 342 LEU   A CB  1 
ATOM   1304 C CG  . LEU   A 1 224 ? -2.65239  56.68765 8.30470   1.000 23.44434 ? 342 LEU   A CG  1 
ATOM   1305 C CD1 . LEU   A 1 224 ? -2.19062  55.23792 8.34393   1.000 22.15275 ? 342 LEU   A CD1 1 
ATOM   1306 C CD2 . LEU   A 1 224 ? -3.73756  56.98424 9.34105   1.000 25.18242 ? 342 LEU   A CD2 1 
ATOM   1307 N N   . MET   A 1 225 ? 0.54708   60.06648 7.86943   1.000 21.13044 ? 343 MET   A N   1 
ATOM   1308 C CA  . MET   A 1 225 ? 1.47095   61.13923 8.24172   1.000 22.74897 ? 343 MET   A CA  1 
ATOM   1309 C C   . MET   A 1 225 ? 0.84196   62.50796 8.04222   1.000 22.98875 ? 343 MET   A C   1 
ATOM   1310 O O   . MET   A 1 225 ? 0.95860   63.38452 8.90540   1.000 19.79042 ? 343 MET   A O   1 
ATOM   1311 C CB  . MET   A 1 225 ? 2.78043   61.05814 7.44680   1.000 22.69620 ? 343 MET   A CB  1 
ATOM   1312 C CG  . MET   A 1 225 ? 3.62407   59.81773 7.76600   1.000 22.49638 ? 343 MET   A CG  1 
ATOM   1313 S SD  . MET   A 1 225 ? 5.20570   59.82008 6.87711   1.000 26.24956 ? 343 MET   A SD  1 
ATOM   1314 C CE  . MET   A 1 225 ? 6.01433   61.25419 7.57698   1.000 25.26548 ? 343 MET   A CE  1 
ATOM   1315 N N   . GLN   A 1 226 ? 0.20253   62.72532 6.88519   1.000 19.32165 ? 344 GLN   A N   1 
ATOM   1316 C CA  . GLN   A 1 226 ? -0.48252  63.99688 6.65258   1.000 21.32734 ? 344 GLN   A CA  1 
ATOM   1317 C C   . GLN   A 1 226 ? -1.53272  64.27025 7.73542   1.000 21.28025 ? 344 GLN   A C   1 
ATOM   1318 O O   . GLN   A 1 226 ? -1.65750  65.39765 8.22995   1.000 21.65630 ? 344 GLN   A O   1 
ATOM   1319 C CB  . GLN   A 1 226 ? -1.12543  63.99292 5.26089   1.000 18.63957 ? 344 GLN   A CB  1 
ATOM   1320 C CG  . GLN   A 1 226 ? -0.10764  64.03923 4.09380   1.000 21.70819 ? 344 GLN   A CG  1 
ATOM   1321 C CD  . GLN   A 1 226 ? -0.77319  63.90574 2.71351   1.000 22.82285 ? 344 GLN   A CD  1 
ATOM   1322 O OE1 . GLN   A 1 226 ? -0.12657  63.53600 1.73771   1.000 22.34715 ? 344 GLN   A OE1 1 
ATOM   1323 N NE2 . GLN   A 1 226 ? -2.06908  64.17556 2.64659   1.000 21.01202 ? 344 GLN   A NE2 1 
ATOM   1324 N N   . ALA   A 1 227 ? -2.33224  63.25756 8.08323   1.000 20.30472 ? 345 ALA   A N   1 
ATOM   1325 C CA  . ALA   A 1 227 ? -3.35294  63.45920 9.11204   1.000 20.72091 ? 345 ALA   A CA  1 
ATOM   1326 C C   . ALA   A 1 227 ? -2.72516  63.80583 10.46001  1.000 24.06025 ? 345 ALA   A C   1 
ATOM   1327 O O   . ALA   A 1 227 ? -3.17167  64.73390 11.15136  1.000 25.52513 ? 345 ALA   A O   1 
ATOM   1328 C CB  . ALA   A 1 227 ? -4.21961  62.20450 9.22961   1.000 24.88678 ? 345 ALA   A CB  1 
ATOM   1329 N N   . ILE   A 1 228 ? -1.67676  63.08107 10.84540  1.000 23.47567 ? 346 ILE   A N   1 
ATOM   1330 C CA  . ILE   A 1 228 ? -1.04376  63.33032 12.14174  1.000 23.11990 ? 346 ILE   A CA  1 
ATOM   1331 C C   . ILE   A 1 228 ? -0.51380  64.75626 12.20869  1.000 27.84151 ? 346 ILE   A C   1 
ATOM   1332 O O   . ILE   A 1 228 ? -0.64802  65.44647 13.23552  1.000 25.43149 ? 346 ILE   A O   1 
ATOM   1333 C CB  . ILE   A 1 228 ? 0.05695   62.27891 12.39313  1.000 22.74842 ? 346 ILE   A CB  1 
ATOM   1334 C CG1 . ILE   A 1 228 ? -0.58389  60.89175 12.55656  1.000 24.82455 ? 346 ILE   A CG1 1 
ATOM   1335 C CG2 . ILE   A 1 228 ? 0.85395   62.62960 13.65988  1.000 26.91667 ? 346 ILE   A CG2 1 
ATOM   1336 C CD1 . ILE   A 1 228 ? 0.41227   59.70787 12.39926  1.000 24.82186 ? 346 ILE   A CD1 1 
ATOM   1337 N N   . SER   A 1 229 ? 0.06546   65.23400 11.10246  1.000 24.76934 ? 347 SER   A N   1 
ATOM   1338 C CA  . SER   A 1 229 ? 0.57037   66.60301 11.04143  1.000 23.26314 ? 347 SER   A CA  1 
ATOM   1339 C C   . SER   A 1 229 ? -0.56686  67.61205 11.08113  1.000 23.10932 ? 347 SER   A C   1 
ATOM   1340 O O   . SER   A 1 229 ? -0.48524  68.63049 11.78216  1.000 25.27832 ? 347 SER   A O   1 
ATOM   1341 C CB  . SER   A 1 229 ? 1.40071   66.79743 9.76442   1.000 23.07703 ? 347 SER   A CB  1 
ATOM   1342 O OG  . SER   A 1 229 ? 1.60824   68.17369 9.52809   1.000 25.71745 ? 347 SER   A OG  1 
ATOM   1343 N N   . LEU   A 1 230 ? -1.63282  67.34953 10.31695  1.000 23.18489 ? 348 LEU   A N   1 
ATOM   1344 C CA  . LEU   A 1 230 ? -2.75561  68.27540 10.24839  1.000 23.75500 ? 348 LEU   A CA  1 
ATOM   1345 C C   . LEU   A 1 230 ? -3.39693  68.45741 11.62251  1.000 27.03548 ? 348 LEU   A C   1 
ATOM   1346 O O   . LEU   A 1 230 ? -3.65879  69.58348 12.05651  1.000 28.27169 ? 348 LEU   A O   1 
ATOM   1347 C CB  . LEU   A 1 230 ? -3.78921  67.75608 9.25063   1.000 21.41230 ? 348 LEU   A CB  1 
ATOM   1348 C CG  . LEU   A 1 230 ? -5.04232  68.61823 9.03568   1.000 29.01805 ? 348 LEU   A CG  1 
ATOM   1349 C CD1 . LEU   A 1 230 ? -4.69619  70.03611 8.59087   1.000 25.56237 ? 348 LEU   A CD1 1 
ATOM   1350 C CD2 . LEU   A 1 230 ? -5.94756  67.95988 8.00420   1.000 28.39856 ? 348 LEU   A CD2 1 
ATOM   1351 N N   . PHE   A 1 231 ? -3.63936  67.35566 12.31934  1.000 26.65883 ? 349 PHE   A N   1 
ATOM   1352 C CA  . PHE   A 1 231 ? -4.36604  67.37577 13.59341  1.000 29.98634 ? 349 PHE   A CA  1 
ATOM   1353 C C   . PHE   A 1 231 ? -3.38022  67.49006 14.75008  1.000 30.23122 ? 349 PHE   A C   1 
ATOM   1354 O O   . PHE   A 1 231 ? -3.29834  66.63153 15.62190  1.000 33.73697 ? 349 PHE   A O   1 
ATOM   1355 C CB  . PHE   A 1 231 ? -5.23615  66.12912 13.72520  1.000 27.56560 ? 349 PHE   A CB  1 
ATOM   1356 C CG  . PHE   A 1 231 ? -6.40183  66.10202 12.77613  1.000 32.37842 ? 349 PHE   A CG  1 
ATOM   1357 C CD1 . PHE   A 1 231 ? -7.58655  66.75259 13.09245  1.000 34.94147 ? 349 PHE   A CD1 1 
ATOM   1358 C CD2 . PHE   A 1 231 ? -6.31512  65.42791 11.56109  1.000 31.98290 ? 349 PHE   A CD2 1 
ATOM   1359 C CE1 . PHE   A 1 231 ? -8.67038  66.73831 12.21042  1.000 34.35019 ? 349 PHE   A CE1 1 
ATOM   1360 C CE2 . PHE   A 1 231 ? -7.39445  65.40081 10.68145  1.000 32.44847 ? 349 PHE   A CE2 1 
ATOM   1361 C CZ  . PHE   A 1 231 ? -8.57400  66.06223 11.00738  1.000 33.07763 ? 349 PHE   A CZ  1 
ATOM   1362 N N   . SER   A 1 232 ? -2.60249  68.57290 14.72409  1.000 32.57210 ? 350 SER   A N   1 
ATOM   1363 C CA  . SER   A 1 232 ? -1.57301  68.79186 15.72567  1.000 39.06407 ? 350 SER   A CA  1 
ATOM   1364 C C   . SER   A 1 232 ? -2.14761  69.70394 16.79069  1.000 36.53677 ? 350 SER   A C   1 
ATOM   1365 O O   . SER   A 1 232 ? -2.39576  70.88551 16.50946  1.000 38.21881 ? 350 SER   A O   1 
ATOM   1366 C CB  . SER   A 1 232 ? -0.31677  69.40686 15.11458  1.000 38.21991 ? 350 SER   A CB  1 
ATOM   1367 O OG  . SER   A 1 232 ? 0.43361   68.43178 14.41061  1.000 40.99394 ? 350 SER   A OG  1 
ATOM   1368 N N   . PRO   A 1 233 ? -2.37038  69.21261 18.01311  1.000 43.38882 ? 351 PRO   A N   1 
ATOM   1369 C CA  . PRO   A 1 233 ? -3.14104  69.97695 19.00702  1.000 44.37858 ? 351 PRO   A CA  1 
ATOM   1370 C C   . PRO   A 1 233 ? -2.43362  71.20883 19.53291  1.000 52.08954 ? 351 PRO   A C   1 
ATOM   1371 O O   . PRO   A 1 233 ? -3.01909  71.94649 20.33505  1.000 52.57804 ? 351 PRO   A O   1 
ATOM   1372 C CB  . PRO   A 1 233 ? -3.34378  68.95020 20.13077  1.000 42.39904 ? 351 PRO   A CB  1 
ATOM   1373 C CG  . PRO   A 1 233 ? -2.05733  68.16781 20.09598  1.000 43.04467 ? 351 PRO   A CG  1 
ATOM   1374 C CD  . PRO   A 1 233 ? -1.77972  67.99411 18.59525  1.000 40.60638 ? 351 PRO   A CD  1 
ATOM   1375 N N   . ASP   A 1 234 ? -1.20293  71.46233 19.09958  1.000 45.33600 ? 352 ASP   A N   1 
ATOM   1376 C CA  . ASP   A 1 234 ? -0.35276  72.48850 19.68485  1.000 50.45779 ? 352 ASP   A CA  1 
ATOM   1377 C C   . ASP   A 1 234 ? 0.05331   73.55839 18.67936  1.000 51.90234 ? 352 ASP   A C   1 
ATOM   1378 O O   . ASP   A 1 234 ? 1.03472   74.27121 18.89809  1.000 56.58771 ? 352 ASP   A O   1 
ATOM   1379 C CB  . ASP   A 1 234 ? 0.87314   71.81798 20.28957  1.000 56.26668 ? 352 ASP   A CB  1 
ATOM   1380 C CG  . ASP   A 1 234 ? 1.47433   70.80619 19.34507  1.000 59.78715 ? 352 ASP   A CG  1 
ATOM   1381 O OD1 . ASP   A 1 234 ? 1.41347   71.06340 18.13159  1.000 57.26369 ? 352 ASP   A OD1 1 
ATOM   1382 O OD2 . ASP   A 1 234 ? 1.98883   69.75789 19.79458  1.000 63.00849 ? 352 ASP   A OD2 1 
ATOM   1383 N N   . ARG   A 1 235 ? -0.66497  73.67464 17.57212  1.000 42.20401 ? 353 ARG   A N   1 
ATOM   1384 C CA  . ARG   A 1 235 ? -0.45560  74.81792 16.70819  1.000 42.62338 ? 353 ARG   A CA  1 
ATOM   1385 C C   . ARG   A 1 235 ? -0.98418  76.07593 17.39489  1.000 46.81656 ? 353 ARG   A C   1 
ATOM   1386 O O   . ARG   A 1 235 ? -1.94785  76.01161 18.16689  1.000 39.71958 ? 353 ARG   A O   1 
ATOM   1387 C CB  . ARG   A 1 235 ? -1.15623  74.61010 15.37016  1.000 40.36574 ? 353 ARG   A CB  1 
ATOM   1388 C CG  . ARG   A 1 235 ? -0.85159  73.25604 14.76714  1.000 35.27613 ? 353 ARG   A CG  1 
ATOM   1389 C CD  . ARG   A 1 235 ? 0.48285   73.26592 14.05026  1.000 35.13642 ? 353 ARG   A CD  1 
ATOM   1390 N NE  . ARG   A 1 235 ? 0.60356   72.10289 13.18417  1.000 33.38200 ? 353 ARG   A NE  1 
ATOM   1391 C CZ  . ARG   A 1 235 ? 1.75052   71.58571 12.76061  1.000 34.95458 ? 353 ARG   A CZ  1 
ATOM   1392 N NH1 . ARG   A 1 235 ? 2.91302   72.15106 13.08885  1.000 31.97755 ? 353 ARG   A NH1 1 
ATOM   1393 N NH2 . ARG   A 1 235 ? 1.72451   70.50906 11.98197  1.000 29.41456 ? 353 ARG   A NH2 1 
ATOM   1394 N N   . PRO   A 1 236 ? -0.36157  77.22426 17.14467  1.000 43.29862 ? 354 PRO   A N   1 
ATOM   1395 C CA  . PRO   A 1 236 ? -0.87544  78.47778 17.70177  1.000 47.31842 ? 354 PRO   A CA  1 
ATOM   1396 C C   . PRO   A 1 236 ? -2.33573  78.69671 17.33671  1.000 45.81290 ? 354 PRO   A C   1 
ATOM   1397 O O   . PRO   A 1 236 ? -2.75708  78.47428 16.19956  1.000 42.92510 ? 354 PRO   A O   1 
ATOM   1398 C CB  . PRO   A 1 236 ? 0.02701   79.54350 17.06556  1.000 45.02941 ? 354 PRO   A CB  1 
ATOM   1399 C CG  . PRO   A 1 236 ? 1.26658   78.81230 16.69099  1.000 44.67444 ? 354 PRO   A CG  1 
ATOM   1400 C CD  . PRO   A 1 236 ? 0.82849   77.44118 16.30428  1.000 42.02842 ? 354 PRO   A CD  1 
ATOM   1401 N N   . GLY   A 1 237 ? -3.11262  79.12561 18.32388  1.000 45.18561 ? 355 GLY   A N   1 
ATOM   1402 C CA  . GLY   A 1 237 ? -4.47561  79.53561 18.09616  1.000 40.64664 ? 355 GLY   A CA  1 
ATOM   1403 C C   . GLY   A 1 237 ? -5.50442  78.43272 18.13447  1.000 49.11685 ? 355 GLY   A C   1 
ATOM   1404 O O   . GLY   A 1 237 ? -6.68209  78.70556 17.87867  1.000 51.56997 ? 355 GLY   A O   1 
ATOM   1405 N N   . VAL   A 1 238 ? -5.11305  77.20074 18.43352  1.000 47.30574 ? 356 VAL   A N   1 
ATOM   1406 C CA  . VAL   A 1 238 ? -6.07821  76.11115 18.49799  1.000 45.48083 ? 356 VAL   A CA  1 
ATOM   1407 C C   . VAL   A 1 238 ? -6.83850  76.21653 19.81199  1.000 49.03459 ? 356 VAL   A C   1 
ATOM   1408 O O   . VAL   A 1 238 ? -6.23544  76.40176 20.87232  1.000 48.89244 ? 356 VAL   A O   1 
ATOM   1409 C CB  . VAL   A 1 238 ? -5.37597  74.75204 18.35670  1.000 47.63500 ? 356 VAL   A CB  1 
ATOM   1410 C CG1 . VAL   A 1 238 ? -6.35699  73.61867 18.60816  1.000 41.27431 ? 356 VAL   A CG1 1 
ATOM   1411 C CG2 . VAL   A 1 238 ? -4.76147  74.61739 16.95669  1.000 42.62932 ? 356 VAL   A CG2 1 
ATOM   1412 N N   . LEU   A 1 239 ? -8.16727  76.12027 19.75011  1.000 48.24052 ? 357 LEU   A N   1 
ATOM   1413 C CA  . LEU   A 1 239 ? -8.95547  76.14107 20.97963  1.000 51.60257 ? 357 LEU   A CA  1 
ATOM   1414 C C   . LEU   A 1 239 ? -9.40395  74.75113 21.40962  1.000 51.93807 ? 357 LEU   A C   1 
ATOM   1415 O O   . LEU   A 1 239 ? -9.31186  74.41081 22.59223  1.000 48.73404 ? 357 LEU   A O   1 
ATOM   1416 C CB  . LEU   A 1 239 ? -10.17594 77.05301 20.83113  1.000 48.19493 ? 357 LEU   A CB  1 
ATOM   1417 C CG  . LEU   A 1 239 ? -9.66818  78.48331 20.60989  1.000 51.02638 ? 357 LEU   A CG  1 
ATOM   1418 C CD1 . LEU   A 1 239 ? -10.80989 79.51489 20.38195  1.000 52.65108 ? 357 LEU   A CD1 1 
ATOM   1419 C CD2 . LEU   A 1 239 ? -8.56983  78.93867 21.64159  1.000 56.40153 ? 357 LEU   A CD2 1 
ATOM   1420 N N   . GLN   A 1 240 ? -9.91497  73.94350 20.47803  1.000 43.30957 ? 358 GLN   A N   1 
ATOM   1421 C CA  . GLN   A 1 240 ? -10.35516 72.60341 20.83994  1.000 38.35265 ? 358 GLN   A CA  1 
ATOM   1422 C C   . GLN   A 1 240 ? -9.16118  71.67882 21.02129  1.000 44.06419 ? 358 GLN   A C   1 
ATOM   1423 O O   . GLN   A 1 240 ? -9.11849  70.59864 20.42444  1.000 41.91716 ? 358 GLN   A O   1 
ATOM   1424 C CB  . GLN   A 1 240 ? -11.32047 72.04213 19.79490  1.000 48.39654 ? 358 GLN   A CB  1 
ATOM   1425 C CG  . GLN   A 1 240 ? -12.61589 72.82641 19.69060  1.000 49.52047 ? 358 GLN   A CG  1 
ATOM   1426 C CD  . GLN   A 1 240 ? -13.49823 72.62490 20.91036  1.000 55.74645 ? 358 GLN   A CD  1 
ATOM   1427 O OE1 . GLN   A 1 240 ? -13.90683 71.50108 21.21818  1.000 55.82672 ? 358 GLN   A OE1 1 
ATOM   1428 N NE2 . GLN   A 1 240 ? -13.78837 73.71464 21.61852  1.000 58.33495 ? 358 GLN   A NE2 1 
ATOM   1429 N N   . HIS   A 1 241 ? -8.20925  72.09552 21.87021  1.000 40.52132 ? 359 HIS   A N   1 
ATOM   1430 C CA  A HIS   A 1 241 ? -6.96219  71.35555 22.07452  0.707 47.11637 ? 359 HIS   A CA  1 
ATOM   1431 C C   . HIS   A 1 241 ? -7.19679  69.87938 22.36020  1.000 45.27261 ? 359 HIS   A C   1 
ATOM   1432 O O   . HIS   A 1 241 ? -6.47783  69.02110 21.83849  1.000 43.14638 ? 359 HIS   A O   1 
ATOM   1433 C CB  A HIS   A 1 241 ? -6.16291  71.96381 23.23213  0.707 49.80507 ? 359 HIS   A CB  1 
ATOM   1434 C CG  A HIS   A 1 241 ? -5.43498  73.21967 22.87713  0.707 56.93646 ? 359 HIS   A CG  1 
ATOM   1435 N ND1 A HIS   A 1 241 ? -4.21094  73.21886 22.24184  0.707 61.28515 ? 359 HIS   A ND1 1 
ATOM   1436 C CD2 A HIS   A 1 241 ? -5.74905  74.52045 23.08695  0.707 58.18528 ? 359 HIS   A CD2 1 
ATOM   1437 C CE1 A HIS   A 1 241 ? -3.80920  74.46564 22.05995  0.707 59.55232 ? 359 HIS   A CE1 1 
ATOM   1438 N NE2 A HIS   A 1 241 ? -4.72476  75.27545 22.56317  0.707 62.91395 ? 359 HIS   A NE2 1 
ATOM   1439 N N   . ARG   A 1 242 ? -8.17249  69.56309 23.21691  1.000 44.35740 ? 360 ARG   A N   1 
ATOM   1440 C CA  . ARG   A 1 242 ? -8.34077  68.18536 23.67093  1.000 39.06167 ? 360 ARG   A CA  1 
ATOM   1441 C C   . ARG   A 1 242 ? -8.87909  67.30249 22.55568  1.000 40.52286 ? 360 ARG   A C   1 
ATOM   1442 O O   . ARG   A 1 242 ? -8.42166  66.16637 22.37398  1.000 42.21324 ? 360 ARG   A O   1 
ATOM   1443 C CB  . ARG   A 1 242 ? -9.27615  68.13310 24.88788  1.000 41.84788 ? 360 ARG   A CB  1 
ATOM   1444 N N   . VAL   A 1 243 ? -9.87447  67.79922 21.81844  1.000 37.28564 ? 361 VAL   A N   1 
ATOM   1445 C CA  . VAL   A 1 243 ? -10.43819 67.03864 20.70541  1.000 47.87423 ? 361 VAL   A CA  1 
ATOM   1446 C C   . VAL   A 1 243 ? -9.36979  66.77343 19.65266  1.000 39.16632 ? 361 VAL   A C   1 
ATOM   1447 O O   . VAL   A 1 243 ? -9.22631  65.64908 19.16015  1.000 37.07506 ? 361 VAL   A O   1 
ATOM   1448 C CB  . VAL   A 1 243 ? -11.63998 67.78260 20.09418  1.000 45.35294 ? 361 VAL   A CB  1 
ATOM   1449 C CG1 . VAL   A 1 243 ? -12.11784 67.06717 18.84343  1.000 42.64771 ? 361 VAL   A CG1 1 
ATOM   1450 C CG2 . VAL   A 1 243 ? -12.77083 67.93116 21.11262  1.000 53.71300 ? 361 VAL   A CG2 1 
ATOM   1451 N N   . VAL   A 1 244 ? -8.61749  67.81225 19.28072  1.000 36.35199 ? 362 VAL   A N   1 
ATOM   1452 C CA  . VAL   A 1 244 ? -7.58259  67.64240 18.26105  1.000 40.29080 ? 362 VAL   A CA  1 
ATOM   1453 C C   . VAL   A 1 244 ? -6.54748  66.63557 18.73573  1.000 35.01780 ? 362 VAL   A C   1 
ATOM   1454 O O   . VAL   A 1 244 ? -6.13097  65.73997 17.98516  1.000 35.00689 ? 362 VAL   A O   1 
ATOM   1455 C CB  . VAL   A 1 244 ? -6.93555  68.99945 17.91343  1.000 35.56918 ? 362 VAL   A CB  1 
ATOM   1456 C CG1 . VAL   A 1 244 ? -5.77750  68.80895 16.92251  1.000 35.70393 ? 362 VAL   A CG1 1 
ATOM   1457 C CG2 . VAL   A 1 244 ? -7.96371  69.95616 17.35911  1.000 34.07981 ? 362 VAL   A CG2 1 
ATOM   1458 N N   . ASP   A 1 245 ? -6.14311  66.74302 20.00481  1.000 34.19050 ? 363 ASP   A N   1 
ATOM   1459 C CA  . ASP   A 1 245 ? -5.15876  65.81859 20.55507  1.000 36.91246 ? 363 ASP   A CA  1 
ATOM   1460 C C   . ASP   A 1 245 ? -5.66189  64.38373 20.53621  1.000 34.18718 ? 363 ASP   A C   1 
ATOM   1461 O O   . ASP   A 1 245 ? -4.88357  63.45585 20.29804  1.000 36.18335 ? 363 ASP   A O   1 
ATOM   1462 C CB  . ASP   A 1 245 ? -4.78407  66.21298 21.98463  1.000 40.37515 ? 363 ASP   A CB  1 
ATOM   1463 C CG  . ASP   A 1 245 ? -3.69781  65.32600 22.55312  1.000 44.11215 ? 363 ASP   A CG  1 
ATOM   1464 O OD1 . ASP   A 1 245 ? -4.01828  64.45784 23.38873  1.000 61.27850 ? 363 ASP   A OD1 1 
ATOM   1465 O OD2 . ASP   A 1 245 ? -2.52303  65.47921 22.16029  1.000 48.29991 ? 363 ASP   A OD2 1 
ATOM   1466 N N   . GLN   A 1 246 ? -6.95898  64.17991 20.78689  1.000 33.80651 ? 364 GLN   A N   1 
ATOM   1467 C CA  . GLN   A 1 246 ? -7.52014  62.83343 20.73447  1.000 40.61760 ? 364 GLN   A CA  1 
ATOM   1468 C C   . GLN   A 1 246 ? -7.57222  62.30312 19.30543  1.000 31.63985 ? 364 GLN   A C   1 
ATOM   1469 O O   . GLN   A 1 246 ? -7.27272  61.12808 19.06213  1.000 31.62643 ? 364 GLN   A O   1 
ATOM   1470 C CB  . GLN   A 1 246 ? -8.91442  62.82931 21.35893  1.000 44.24779 ? 364 GLN   A CB  1 
ATOM   1471 C CG  . GLN   A 1 246 ? -8.87859  63.05633 22.88137  1.000 55.66371 ? 364 GLN   A CG  1 
ATOM   1472 C CD  . GLN   A 1 246 ? -10.25754 63.08077 23.50766  1.000 58.12612 ? 364 GLN   A CD  1 
ATOM   1473 O OE1 . GLN   A 1 246 ? -10.94700 62.06231 23.55699  1.000 65.91711 ? 364 GLN   A OE1 1 
ATOM   1474 N NE2 . GLN   A 1 246 ? -10.67341 64.25422 23.97954  1.000 61.22730 ? 364 GLN   A NE2 1 
ATOM   1475 N N   . LEU   A 1 247 ? -7.98019  63.14286 18.35620  1.000 34.08754 ? 365 LEU   A N   1 
ATOM   1476 C CA  . LEU   A 1 247 ? -7.96472  62.73963 16.95065  1.000 34.34426 ? 365 LEU   A CA  1 
ATOM   1477 C C   . LEU   A 1 247 ? -6.55438  62.36768 16.49864  1.000 27.26375 ? 365 LEU   A C   1 
ATOM   1478 O O   . LEU   A 1 247 ? -6.34664  61.33518 15.84316  1.000 31.06266 ? 365 LEU   A O   1 
ATOM   1479 C CB  . LEU   A 1 247 ? -8.53285  63.86492 16.08332  1.000 34.55091 ? 365 LEU   A CB  1 
ATOM   1480 C CG  . LEU   A 1 247 ? -10.03741 64.13504 16.18201  1.000 39.71422 ? 365 LEU   A CG  1 
ATOM   1481 C CD1 . LEU   A 1 247 ? -10.38140 65.48692 15.56932  1.000 36.50878 ? 365 LEU   A CD1 1 
ATOM   1482 C CD2 . LEU   A 1 247 ? -10.81937 63.02482 15.51658  1.000 44.13774 ? 365 LEU   A CD2 1 
ATOM   1483 N N   . GLN   A 1 248 ? -5.56562  63.19464 16.84819  1.000 31.66738 ? 366 GLN   A N   1 
ATOM   1484 C CA  . GLN   A 1 248 ? -4.18788  62.87652 16.49058  1.000 31.02870 ? 366 GLN   A CA  1 
ATOM   1485 C C   . GLN   A 1 248 ? -3.77597  61.51569 17.02870  1.000 36.28361 ? 366 GLN   A C   1 
ATOM   1486 O O   . GLN   A 1 248 ? -3.16707  60.70877 16.31095  1.000 26.97515 ? 366 GLN   A O   1 
ATOM   1487 C CB  . GLN   A 1 248 ? -3.22655  63.94414 17.00623  1.000 31.32675 ? 366 GLN   A CB  1 
ATOM   1488 C CG  . GLN   A 1 248 ? -1.87933  63.86824 16.26362  1.000 33.32952 ? 366 GLN   A CG  1 
ATOM   1489 C CD  . GLN   A 1 248 ? -0.81256  64.73955 16.88100  1.000 36.84338 ? 366 GLN   A CD  1 
ATOM   1490 O OE1 . GLN   A 1 248 ? -0.61621  64.73142 18.09281  1.000 34.48110 ? 366 GLN   A OE1 1 
ATOM   1491 N NE2 . GLN   A 1 248 ? -0.11441  65.50127 16.04712  1.000 27.66978 ? 366 GLN   A NE2 1 
ATOM   1492 N N   . GLU   A 1 249 ? -4.08327  61.24830 18.30506  1.000 35.82254 ? 367 GLU   A N   1 
ATOM   1493 C CA  . GLU   A 1 249 ? -3.70648  59.96883 18.88815  1.000 31.97013 ? 367 GLU   A CA  1 
ATOM   1494 C C   . GLU   A 1 249 ? -4.35262  58.81788 18.13216  1.000 27.91189 ? 367 GLU   A C   1 
ATOM   1495 O O   . GLU   A 1 249 ? -3.73486  57.76254 17.93887  1.000 34.32238 ? 367 GLU   A O   1 
ATOM   1496 C CB  . GLU   A 1 249 ? -4.09164  59.92380 20.37382  1.000 36.91747 ? 367 GLU   A CB  1 
ATOM   1497 C CG  . GLU   A 1 249 ? -3.76555  58.58694 21.02962  1.000 43.57123 ? 367 GLU   A CG  1 
ATOM   1498 C CD  . GLU   A 1 249 ? -4.18326  58.50799 22.50040  1.000 53.29207 ? 367 GLU   A CD  1 
ATOM   1499 O OE1 . GLU   A 1 249 ? -5.12131  59.22986 22.91076  1.000 51.86263 ? 367 GLU   A OE1 1 
ATOM   1500 O OE2 . GLU   A 1 249 ? -3.55768  57.72101 23.24616  1.000 58.11828 ? 367 GLU   A OE2 1 
ATOM   1501 N N   . GLN   A 1 250 ? -5.59934  58.99304 17.70393  1.000 31.40123 ? 368 GLN   A N   1 
ATOM   1502 C CA  A GLN   A 1 250 ? -6.26128  57.92349 16.96581  0.842 35.32510 ? 368 GLN   A CA  1 
ATOM   1503 C C   . GLN   A 1 250 ? -5.58048  57.67295 15.62526  1.000 33.07530 ? 368 GLN   A C   1 
ATOM   1504 O O   . GLN   A 1 250 ? -5.40026  56.51649 15.22038  1.000 27.68087 ? 368 GLN   A O   1 
ATOM   1505 C CB  A GLN   A 1 250 ? -7.73940  58.25282 16.76791  0.842 30.26460 ? 368 GLN   A CB  1 
ATOM   1506 C CG  A GLN   A 1 250 ? -8.58778  58.30688 18.04837  0.842 40.13257 ? 368 GLN   A CG  1 
ATOM   1507 C CD  A GLN   A 1 250 ? -8.10248  57.38298 19.17394  0.842 50.14805 ? 368 GLN   A CD  1 
ATOM   1508 O OE1 A GLN   A 1 250 ? -7.77351  56.21026 18.94995  0.842 48.18121 ? 368 GLN   A OE1 1 
ATOM   1509 N NE2 A GLN   A 1 250 ? -8.07783  57.91266 20.40196  0.842 46.56381 ? 368 GLN   A NE2 1 
ATOM   1510 N N   . PHE   A 1 251 ? -5.18504  58.74350 14.92558  1.000 29.99876 ? 369 PHE   A N   1 
ATOM   1511 C CA  . PHE   A 1 251 ? -4.48855  58.56182 13.65234  1.000 31.86293 ? 369 PHE   A CA  1 
ATOM   1512 C C   . PHE   A 1 251 ? -3.14940  57.86256 13.85702  1.000 28.45959 ? 369 PHE   A C   1 
ATOM   1513 O O   . PHE   A 1 251 ? -2.76501  56.99787 13.05909  1.000 28.28658 ? 369 PHE   A O   1 
ATOM   1514 C CB  . PHE   A 1 251 ? -4.28972  59.91230 12.96223  1.000 24.30829 ? 369 PHE   A CB  1 
ATOM   1515 C CG  . PHE   A 1 251 ? -5.55728  60.49453 12.37224  1.000 23.00661 ? 369 PHE   A CG  1 
ATOM   1516 C CD1 . PHE   A 1 251 ? -6.26050  59.81156 11.39423  1.000 28.08581 ? 369 PHE   A CD1 1 
ATOM   1517 C CD2 . PHE   A 1 251 ? -6.02003  61.73609 12.77141  1.000 29.08453 ? 369 PHE   A CD2 1 
ATOM   1518 C CE1 . PHE   A 1 251 ? -7.42017  60.35678 10.83444  1.000 30.09764 ? 369 PHE   A CE1 1 
ATOM   1519 C CE2 . PHE   A 1 251 ? -7.18596  62.28130 12.21145  1.000 27.96496 ? 369 PHE   A CE2 1 
ATOM   1520 C CZ  . PHE   A 1 251 ? -7.87304  61.58968 11.25337  1.000 30.57922 ? 369 PHE   A CZ  1 
ATOM   1521 N N   . ALA   A 1 252 ? -2.42613  58.22204 14.92598  1.000 30.61006 ? 370 ALA   A N   1 
ATOM   1522 C CA  . ALA   A 1 252 ? -1.14503  57.57927 15.20852  1.000 29.88745 ? 370 ALA   A CA  1 
ATOM   1523 C C   . ALA   A 1 252 ? -1.33208  56.10864 15.56623  1.000 27.64381 ? 370 ALA   A C   1 
ATOM   1524 O O   . ALA   A 1 252 ? -0.56309  55.25712 15.11489  1.000 28.36580 ? 370 ALA   A O   1 
ATOM   1525 C CB  . ALA   A 1 252 ? -0.42007  58.31638 16.33969  1.000 29.50916 ? 370 ALA   A CB  1 
ATOM   1526 N N   . ILE   A 1 253 ? -2.35770  55.78622 16.36417  1.000 28.45929 ? 371 ILE   A N   1 
ATOM   1527 C CA  . ILE   A 1 253 ? -2.61800  54.38219 16.69006  1.000 32.61533 ? 371 ILE   A CA  1 
ATOM   1528 C C   . ILE   A 1 253 ? -2.96192  53.60074 15.42942  1.000 27.01529 ? 371 ILE   A C   1 
ATOM   1529 O O   . ILE   A 1 253 ? -2.46648  52.48885 15.20997  1.000 27.33414 ? 371 ILE   A O   1 
ATOM   1530 C CB  . ILE   A 1 253 ? -3.73674  54.26782 17.74483  1.000 30.34262 ? 371 ILE   A CB  1 
ATOM   1531 C CG1 . ILE   A 1 253 ? -3.21830  54.70114 19.11960  1.000 38.07416 ? 371 ILE   A CG1 1 
ATOM   1532 C CG2 . ILE   A 1 253 ? -4.29045  52.83662 17.79445  1.000 34.67057 ? 371 ILE   A CG2 1 
ATOM   1533 C CD1 . ILE   A 1 253 ? -4.31693  54.86408 20.15984  1.000 40.01545 ? 371 ILE   A CD1 1 
ATOM   1534 N N   . THR   A 1 254 ? -3.81980  54.17350 14.58008  1.000 27.61162 ? 372 THR   A N   1 
ATOM   1535 C CA  . THR   A 1 254 ? -4.12627  53.53741 13.30065  1.000 29.78744 ? 372 THR   A CA  1 
ATOM   1536 C C   . THR   A 1 254 ? -2.84910  53.26800 12.49710  1.000 27.85925 ? 372 THR   A C   1 
ATOM   1537 O O   . THR   A 1 254 ? -2.68078  52.18161 11.92556  1.000 25.11737 ? 372 THR   A O   1 
ATOM   1538 C CB  . THR   A 1 254 ? -5.12102  54.41007 12.51344  1.000 30.11942 ? 372 THR   A CB  1 
ATOM   1539 O OG1 . THR   A 1 254 ? -6.36857  54.49927 13.22302  1.000 32.61553 ? 372 THR   A OG1 1 
ATOM   1540 C CG2 . THR   A 1 254 ? -5.39486  53.83984 11.12455  1.000 29.04752 ? 372 THR   A CG2 1 
ATOM   1541 N N   . LEU   A 1 255 ? -1.91620  54.23092 12.47632  1.000 24.13533 ? 373 LEU   A N   1 
ATOM   1542 C CA  . LEU   A 1 255 ? -0.69509  54.03799 11.69835  1.000 27.63457 ? 373 LEU   A CA  1 
ATOM   1543 C C   . LEU   A 1 255 ? 0.17727   52.95223 12.31406  1.000 28.23548 ? 373 LEU   A C   1 
ATOM   1544 O O   . LEU   A 1 255 ? 0.72345   52.10264 11.59712  1.000 22.56434 ? 373 LEU   A O   1 
ATOM   1545 C CB  . LEU   A 1 255 ? 0.08075   55.35687 11.57850  1.000 26.49245 ? 373 LEU   A CB  1 
ATOM   1546 C CG  . LEU   A 1 255 ? 1.48847   55.24388 10.95930  1.000 27.87811 ? 373 LEU   A CG  1 
ATOM   1547 C CD1 . LEU   A 1 255 ? 1.46794   54.76943 9.47880   1.000 26.68033 ? 373 LEU   A CD1 1 
ATOM   1548 C CD2 . LEU   A 1 255 ? 2.28747   56.55799 11.10989  1.000 25.51960 ? 373 LEU   A CD2 1 
ATOM   1549 N N   . LYS   A 1 256 ? 0.31429   52.97159 13.64538  1.000 28.49132 ? 374 LYS   A N   1 
ATOM   1550 C CA  . LYS   A 1 256 ? 1.04935   51.92109 14.34384  1.000 29.93309 ? 374 LYS   A CA  1 
ATOM   1551 C C   . LYS   A 1 256 ? 0.46639   50.54366 14.02817  1.000 26.44224 ? 374 LYS   A C   1 
ATOM   1552 O O   . LYS   A 1 256 ? 1.20479   49.60522 13.71281  1.000 28.39552 ? 374 LYS   A O   1 
ATOM   1553 C CB  . LYS   A 1 256 ? 1.03241   52.21850 15.85590  1.000 26.95650 ? 374 LYS   A CB  1 
ATOM   1554 C CG  . LYS   A 1 256 ? 1.84605   51.25334 16.76326  1.000 33.13633 ? 374 LYS   A CG  1 
ATOM   1555 C CD  . LYS   A 1 256 ? 1.89934   51.82938 18.20097  1.000 31.73962 ? 374 LYS   A CD  1 
ATOM   1556 C CE  . LYS   A 1 256 ? 2.76098   50.99123 19.14222  1.000 43.00832 ? 374 LYS   A CE  1 
ATOM   1557 N NZ  . LYS   A 1 256 ? 2.42242   49.55914 19.02218  1.000 46.04659 ? 374 LYS   A NZ  1 
ATOM   1558 N N   . SER   A 1 257 ? -0.86620  50.41656 14.06794  1.000 26.66402 ? 375 SER   A N   1 
ATOM   1559 C CA  . SER   A 1 257 ? -1.50979  49.12779 13.79716  1.000 34.49153 ? 375 SER   A CA  1 
ATOM   1560 C C   . SER   A 1 257 ? -1.40604  48.72775 12.32910  1.000 31.34696 ? 375 SER   A C   1 
ATOM   1561 O O   . SER   A 1 257 ? -1.24972  47.53795 12.01362  1.000 30.10230 ? 375 SER   A O   1 
ATOM   1562 C CB  . SER   A 1 257 ? -2.97996  49.16919 14.21768  1.000 34.02891 ? 375 SER   A CB  1 
ATOM   1563 O OG  . SER   A 1 257 ? -3.09128  49.31253 15.62124  1.000 42.27476 ? 375 SER   A OG  1 
ATOM   1564 N N   . TYR   A 1 258 ? -1.54040  49.69197 11.41436  1.000 29.83451 ? 376 TYR   A N   1 
ATOM   1565 C CA  . TYR   A 1 258 ? -1.33351  49.38581 10.00230  1.000 28.80478 ? 376 TYR   A CA  1 
ATOM   1566 C C   . TYR   A 1 258 ? 0.04445   48.77804 9.77568   1.000 29.64127 ? 376 TYR   A C   1 
ATOM   1567 O O   . TYR   A 1 258 ? 0.18138   47.76455 9.08126   1.000 30.29722 ? 376 TYR   A O   1 
ATOM   1568 C CB  . TYR   A 1 258 ? -1.51617  50.64048 9.14287   1.000 27.53864 ? 376 TYR   A CB  1 
ATOM   1569 C CG  . TYR   A 1 258 ? -1.23991  50.41141 7.66468   1.000 33.01677 ? 376 TYR   A CG  1 
ATOM   1570 C CD1 . TYR   A 1 258 ? 0.05251   50.50151 7.15075   1.000 29.51865 ? 376 TYR   A CD1 1 
ATOM   1571 C CD2 . TYR   A 1 258 ? -2.27308  50.10677 6.77848   1.000 33.29220 ? 376 TYR   A CD2 1 
ATOM   1572 C CE1 . TYR   A 1 258 ? 0.30326   50.28920 5.78523   1.000 32.85205 ? 376 TYR   A CE1 1 
ATOM   1573 C CE2 . TYR   A 1 258 ? -2.02368  49.90896 5.40902   1.000 28.12662 ? 376 TYR   A CE2 1 
ATOM   1574 C CZ  . TYR   A 1 258 ? -0.74880  49.99693 4.92664   1.000 28.28692 ? 376 TYR   A CZ  1 
ATOM   1575 O OH  . TYR   A 1 258 ? -0.51307  49.79097 3.58317   1.000 30.48123 ? 376 TYR   A OH  1 
ATOM   1576 N N   . ILE   A 1 259 ? 1.08197   49.38838 10.35469  1.000 29.02419 ? 377 ILE   A N   1 
ATOM   1577 C CA  . ILE   A 1 259 ? 2.44516   48.88813 10.16304  1.000 25.79222 ? 377 ILE   A CA  1 
ATOM   1578 C C   . ILE   A 1 259 ? 2.59306   47.50329 10.77689  1.000 31.31530 ? 377 ILE   A C   1 
ATOM   1579 O O   . ILE   A 1 259 ? 3.23563   46.61545 10.20313  1.000 33.26897 ? 377 ILE   A O   1 
ATOM   1580 C CB  . ILE   A 1 259 ? 3.46642   49.87827 10.75712  1.000 29.10779 ? 377 ILE   A CB  1 
ATOM   1581 C CG1 . ILE   A 1 259 ? 3.54184   51.15310 9.89073   1.000 27.99014 ? 377 ILE   A CG1 1 
ATOM   1582 C CG2 . ILE   A 1 259 ? 4.82702   49.21587 10.90812  1.000 29.08183 ? 377 ILE   A CG2 1 
ATOM   1583 C CD1 . ILE   A 1 259 ? 4.06042   52.37061 10.62246  1.000 29.10165 ? 377 ILE   A CD1 1 
ATOM   1584 N N   . GLU   A 1 260 ? 1.99785   47.29458 11.95203  1.000 29.24919 ? 378 GLU   A N   1 
ATOM   1585 C CA  . GLU   A 1 260 ? 2.10431   45.98650 12.59106  1.000 40.18520 ? 378 GLU   A CA  1 
ATOM   1586 C C   . GLU   A 1 260 ? 1.43576   44.90857 11.75210  1.000 38.83573 ? 378 GLU   A C   1 
ATOM   1587 O O   . GLU   A 1 260 ? 1.94379   43.78587 11.65238  1.000 39.15847 ? 378 GLU   A O   1 
ATOM   1588 C CB  . GLU   A 1 260 ? 1.48630   46.02350 13.98355  1.000 33.44064 ? 378 GLU   A CB  1 
ATOM   1589 C CG  . GLU   A 1 260 ? 2.42401   46.47838 15.05169  1.000 44.12938 ? 378 GLU   A CG  1 
ATOM   1590 C CD  . GLU   A 1 260 ? 1.71217   46.64024 16.37828  1.000 55.23147 ? 378 GLU   A CD  1 
ATOM   1591 O OE1 . GLU   A 1 260 ? 0.64554   46.00646 16.54523  1.000 56.05654 ? 378 GLU   A OE1 1 
ATOM   1592 O OE2 . GLU   A 1 260 ? 2.21435   47.39631 17.24260  1.000 53.82196 ? 378 GLU   A OE2 1 
ATOM   1593 N N   . CYS   A 1 261 ? 0.29728   45.23479 11.13700  1.000 33.32328 ? 379 CYS   A N   1 
ATOM   1594 C CA  . CYS   A 1 261 ? -0.45969  44.23732 10.39499  1.000 37.59905 ? 379 CYS   A CA  1 
ATOM   1595 C C   . CYS   A 1 261 ? 0.10371   43.98045 9.00587   1.000 40.78961 ? 379 CYS   A C   1 
ATOM   1596 O O   . CYS   A 1 261 ? -0.05885  42.87804 8.47846   1.000 41.09049 ? 379 CYS   A O   1 
ATOM   1597 C CB  . CYS   A 1 261 ? -1.92525  44.66464 10.28095  1.000 42.59121 ? 379 CYS   A CB  1 
ATOM   1598 S SG  . CYS   A 1 261 ? -2.77919  44.82879 11.86825  1.000 62.66576 ? 379 CYS   A SG  1 
ATOM   1599 N N   . ASN   A 1 262 ? 0.75924   44.95784 8.38669   1.000 37.21110 ? 380 ASN   A N   1 
ATOM   1600 C CA  . ASN   A 1 262 ? 1.16070   44.79471 6.99840   1.000 38.33314 ? 380 ASN   A CA  1 
ATOM   1601 C C   . ASN   A 1 262 ? 2.66507   44.81720 6.76233   1.000 39.66919 ? 380 ASN   A C   1 
ATOM   1602 O O   . ASN   A 1 262 ? 3.08868   44.67007 5.61409   1.000 48.44882 ? 380 ASN   A O   1 
ATOM   1603 C CB  . ASN   A 1 262 ? 0.49263   45.86589 6.12820   1.000 41.62290 ? 380 ASN   A CB  1 
ATOM   1604 C CG  . ASN   A 1 262 ? -1.02046  45.85026 6.24016   1.000 43.64795 ? 380 ASN   A CG  1 
ATOM   1605 O OD1 . ASN   A 1 262 ? -1.63674  46.82293 6.67705   1.000 48.88361 ? 380 ASN   A OD1 1 
ATOM   1606 N ND2 . ASN   A 1 262 ? -1.62903  44.73849 5.84963   1.000 47.01174 ? 380 ASN   A ND2 1 
ATOM   1607 N N   . ARG   A 1 263 ? 3.48531   44.99333 7.79343   1.000 40.40378 ? 381 ARG   A N   1 
ATOM   1608 C CA  . ARG   A 1 263 ? 4.93824   45.06924 7.62809   1.000 44.87405 ? 381 ARG   A CA  1 
ATOM   1609 C C   . ARG   A 1 263 ? 5.63699   44.24082 8.69662   1.000 45.92622 ? 381 ARG   A C   1 
ATOM   1610 O O   . ARG   A 1 263 ? 6.20750   44.77573 9.65833   1.000 47.76030 ? 381 ARG   A O   1 
ATOM   1611 C CB  . ARG   A 1 263 ? 5.41531   46.51701 7.67169   1.000 40.68059 ? 381 ARG   A CB  1 
ATOM   1612 C CG  . ARG   A 1 263 ? 4.87580   47.37364 6.55005   1.000 38.01502 ? 381 ARG   A CG  1 
ATOM   1613 C CD  . ARG   A 1 263 ? 5.44623   48.73327 6.74810   1.000 40.66081 ? 381 ARG   A CD  1 
ATOM   1614 N NE  . ARG   A 1 263 ? 5.27522   49.66729 5.64548   1.000 35.97728 ? 381 ARG   A NE  1 
ATOM   1615 C CZ  . ARG   A 1 263 ? 6.08835   49.74927 4.59867   1.000 35.15751 ? 381 ARG   A CZ  1 
ATOM   1616 N NH1 . ARG   A 1 263 ? 7.11097   48.91386 4.47183   1.000 39.04702 ? 381 ARG   A NH1 1 
ATOM   1617 N NH2 . ARG   A 1 263 ? 5.87522   50.67461 3.67798   1.000 32.07917 ? 381 ARG   A NH2 1 
ATOM   1618 N N   . PRO   A 1 264 ? 5.63785   42.91640 8.54266   1.000 47.16787 ? 382 PRO   A N   1 
ATOM   1619 C CA  . PRO   A 1 264 ? 6.28762   42.04426 9.52868   1.000 49.99077 ? 382 PRO   A CA  1 
ATOM   1620 C C   . PRO   A 1 264 ? 7.79389   41.91166 9.35786   1.000 52.82532 ? 382 PRO   A C   1 
ATOM   1621 O O   . PRO   A 1 264 ? 8.41623   41.15473 10.11294  1.000 55.81891 ? 382 PRO   A O   1 
ATOM   1622 C CB  . PRO   A 1 264 ? 5.60092   40.70068 9.27095   1.000 56.31006 ? 382 PRO   A CB  1 
ATOM   1623 C CG  . PRO   A 1 264 ? 5.40051   40.71198 7.76846   1.000 50.44450 ? 382 PRO   A CG  1 
ATOM   1624 C CD  . PRO   A 1 264 ? 5.07225   42.15569 7.41469   1.000 47.11727 ? 382 PRO   A CD  1 
ATOM   1625 N N   . GLN   A 1 265 ? 8.40486   42.62112 8.40245   1.000 45.11750 ? 383 GLN   A N   1 
ATOM   1626 C CA  . GLN   A 1 265 ? 9.79512   42.33211 8.05662   1.000 50.71835 ? 383 GLN   A CA  1 
ATOM   1627 C C   . GLN   A 1 265 ? 10.76024  43.03773 9.01477   1.000 52.24855 ? 383 GLN   A C   1 
ATOM   1628 O O   . GLN   A 1 265 ? 10.49850  44.16715 9.44025   1.000 50.78486 ? 383 GLN   A O   1 
ATOM   1629 C CB  . GLN   A 1 265 ? 10.08217  42.75160 6.61433   1.000 51.10397 ? 383 GLN   A CB  1 
ATOM   1630 C CG  . GLN   A 1 265 ? 9.28273   41.96598 5.55969   1.000 48.25273 ? 383 GLN   A CG  1 
ATOM   1631 C CD  . GLN   A 1 265 ? 7.92773   42.58269 5.22642   1.000 53.34299 ? 383 GLN   A CD  1 
ATOM   1632 O OE1 . GLN   A 1 265 ? 7.50264   43.57081 5.83229   1.000 50.25361 ? 383 GLN   A OE1 1 
ATOM   1633 N NE2 . GLN   A 1 265 ? 7.24434   41.99789 4.25071   1.000 52.38124 ? 383 GLN   A NE2 1 
ATOM   1634 N N   . PRO   A 1 266 ? 11.88846  42.38311 9.37306   1.000 53.63435 ? 384 PRO   A N   1 
ATOM   1635 C CA  . PRO   A 1 266 ? 12.86832  43.00267 10.28427  1.000 50.65236 ? 384 PRO   A CA  1 
ATOM   1636 C C   . PRO   A 1 266 ? 13.35489  44.38317 9.86876   1.000 50.69695 ? 384 PRO   A C   1 
ATOM   1637 O O   . PRO   A 1 266 ? 13.82240  45.14727 10.72154  1.000 52.13066 ? 384 PRO   A O   1 
ATOM   1638 C CB  . PRO   A 1 266 ? 14.01894  41.98812 10.28042  1.000 51.96506 ? 384 PRO   A CB  1 
ATOM   1639 C CG  . PRO   A 1 266 ? 13.32576  40.67442 10.12283  1.000 51.79585 ? 384 PRO   A CG  1 
ATOM   1640 C CD  . PRO   A 1 266 ? 12.17371  40.94884 9.16106   1.000 53.99548 ? 384 PRO   A CD  1 
ATOM   1641 N N   . ALA   A 1 267 ? 13.25338  44.71983 8.57690   1.000 45.47425 ? 385 ALA   A N   1 
ATOM   1642 C CA  . ALA   A 1 267 ? 13.63749  46.05896 8.13838   1.000 50.66357 ? 385 ALA   A CA  1 
ATOM   1643 C C   . ALA   A 1 267 ? 12.66275  47.11347 8.64137   1.000 56.81751 ? 385 ALA   A C   1 
ATOM   1644 O O   . ALA   A 1 267 ? 13.04739  48.27756 8.83501   1.000 48.61650 ? 385 ALA   A O   1 
ATOM   1645 C CB  . ALA   A 1 267 ? 13.73741  46.12267 6.61217   1.000 44.99189 ? 385 ALA   A CB  1 
ATOM   1646 N N   . HIS   A 1 268 ? 11.41060  46.72442 8.87653   1.000 46.97216 ? 386 HIS   A N   1 
ATOM   1647 C CA  . HIS   A 1 268 ? 10.38395  47.65401 9.31131   1.000 41.12114 ? 386 HIS   A CA  1 
ATOM   1648 C C   . HIS   A 1 268 ? 10.19086  47.63780 10.81549  1.000 35.47299 ? 386 HIS   A C   1 
ATOM   1649 O O   . HIS   A 1 268 ? 9.22466   48.22332 11.31259  1.000 32.77715 ? 386 HIS   A O   1 
ATOM   1650 C CB  . HIS   A 1 268 ? 9.08649   47.35360 8.57334   1.000 39.53342 ? 386 HIS   A CB  1 
ATOM   1651 C CG  . HIS   A 1 268 ? 9.27786   47.25028 7.09261   1.000 42.37044 ? 386 HIS   A CG  1 
ATOM   1652 N ND1 . HIS   A 1 268 ? 8.87186   46.15590 6.35913   1.000 45.91658 ? 386 HIS   A ND1 1 
ATOM   1653 C CD2 . HIS   A 1 268 ? 9.87544   48.09027 6.21524   1.000 40.61420 ? 386 HIS   A CD2 1 
ATOM   1654 C CE1 . HIS   A 1 268 ? 9.19066   46.33571 5.08967   1.000 45.46749 ? 386 HIS   A CE1 1 
ATOM   1655 N NE2 . HIS   A 1 268 ? 9.80795   47.49911 4.97694   1.000 41.97421 ? 386 HIS   A NE2 1 
ATOM   1656 N N   . ARG   A 1 269 ? 11.09360  46.98830 11.54996  1.000 32.21061 ? 387 ARG   A N   1 
ATOM   1657 C CA  . ARG   A 1 269 ? 11.10730  47.16392 12.99209  1.000 33.32321 ? 387 ARG   A CA  1 
ATOM   1658 C C   . ARG   A 1 269 ? 11.34310  48.62878 13.30462  1.000 31.79047 ? 387 ARG   A C   1 
ATOM   1659 O O   . ARG   A 1 269 ? 12.17946  49.28931 12.67772  1.000 37.14310 ? 387 ARG   A O   1 
ATOM   1660 C CB  . ARG   A 1 269 ? 12.19277  46.30327 13.63671  1.000 32.38657 ? 387 ARG   A CB  1 
ATOM   1661 C CG  . ARG   A 1 269 ? 11.77232  44.87870 13.85337  1.000 35.55262 ? 387 ARG   A CG  1 
ATOM   1662 C CD  . ARG   A 1 269 ? 12.94867  44.06503 14.34547  1.000 34.95467 ? 387 ARG   A CD  1 
ATOM   1663 N NE  . ARG   A 1 269 ? 13.19289  44.29223 15.76967  1.000 29.25111 ? 387 ARG   A NE  1 
ATOM   1664 C CZ  . ARG   A 1 269 ? 14.27007  43.86237 16.41821  1.000 25.75715 ? 387 ARG   A CZ  1 
ATOM   1665 N NH1 . ARG   A 1 269 ? 15.21989  43.18287 15.76765  1.000 21.04711 ? 387 ARG   A NH1 1 
ATOM   1666 N NH2 . ARG   A 1 269 ? 14.39185  44.11385 17.71451  1.000 23.67085 ? 387 ARG   A NH2 1 
ATOM   1667 N N   . PHE   A 1 270 ? 10.56958  49.14430 14.24907  1.000 27.16853 ? 388 PHE   A N   1 
ATOM   1668 C CA  . PHE   A 1 270 ? 10.65704  50.52431 14.70227  1.000 34.09847 ? 388 PHE   A CA  1 
ATOM   1669 C C   . PHE   A 1 270 ? 10.23610  51.51118 13.61538  1.000 30.12016 ? 388 PHE   A C   1 
ATOM   1670 O O   . PHE   A 1 270 ? 10.45267  52.71716 13.77834  1.000 26.87184 ? 388 PHE   A O   1 
ATOM   1671 C CB  . PHE   A 1 270 ? 12.06863  50.87321 15.21041  1.000 26.65769 ? 388 PHE   A CB  1 
ATOM   1672 C CG  . PHE   A 1 270 ? 12.69123  49.80351 16.09962  1.000 27.15834 ? 388 PHE   A CG  1 
ATOM   1673 C CD1 . PHE   A 1 270 ? 12.05286  49.39206 17.26341  1.000 32.16864 ? 388 PHE   A CD1 1 
ATOM   1674 C CD2 . PHE   A 1 270 ? 13.91432  49.22907 15.77370  1.000 32.69943 ? 388 PHE   A CD2 1 
ATOM   1675 C CE1 . PHE   A 1 270 ? 12.62124  48.42040 18.08767  1.000 30.97930 ? 388 PHE   A CE1 1 
ATOM   1676 C CE2 . PHE   A 1 270 ? 14.49297  48.25778 16.59622  1.000 28.49178 ? 388 PHE   A CE2 1 
ATOM   1677 C CZ  . PHE   A 1 270 ? 13.83735  47.85670 17.74705  1.000 26.99561 ? 388 PHE   A CZ  1 
ATOM   1678 N N   . LEU   A 1 271 ? 9.63788   51.03807 12.51508  1.000 32.55795 ? 389 LEU   A N   1 
ATOM   1679 C CA  . LEU   A 1 271 ? 9.20292   51.95886 11.46249  1.000 31.88521 ? 389 LEU   A CA  1 
ATOM   1680 C C   . LEU   A 1 271 ? 8.23377   52.99785 12.01205  1.000 26.71397 ? 389 LEU   A C   1 
ATOM   1681 O O   . LEU   A 1 271 ? 8.39020   54.20064 11.76765  1.000 26.79959 ? 389 LEU   A O   1 
ATOM   1682 C CB  . LEU   A 1 271 ? 8.56779   51.19422 10.30533  1.000 30.47747 ? 389 LEU   A CB  1 
ATOM   1683 C CG  . LEU   A 1 271 ? 8.06712   52.11815 9.18137   1.000 34.08146 ? 389 LEU   A CG  1 
ATOM   1684 C CD1 . LEU   A 1 271 ? 9.19884   52.96616 8.55532   1.000 24.24428 ? 389 LEU   A CD1 1 
ATOM   1685 C CD2 . LEU   A 1 271 ? 7.34347   51.32523 8.10517   1.000 33.44152 ? 389 LEU   A CD2 1 
ATOM   1686 N N   . PHE   A 1 272 ? 7.25244   52.56394 12.80936  1.000 26.54906 ? 390 PHE   A N   1 
ATOM   1687 C CA  . PHE   A 1 272 ? 6.31957   53.53444 13.36726  1.000 28.15133 ? 390 PHE   A CA  1 
ATOM   1688 C C   . PHE   A 1 272 ? 7.05200   54.62179 14.14405  1.000 30.23381 ? 390 PHE   A C   1 
ATOM   1689 O O   . PHE   A 1 272 ? 6.73154   55.80982 14.00779  1.000 25.01389 ? 390 PHE   A O   1 
ATOM   1690 C CB  . PHE   A 1 272 ? 5.27723   52.86314 14.26448  1.000 26.35094 ? 390 PHE   A CB  1 
ATOM   1691 C CG  . PHE   A 1 272 ? 4.44811   53.84770 15.03194  1.000 28.92596 ? 390 PHE   A CG  1 
ATOM   1692 C CD1 . PHE   A 1 272 ? 3.52825   54.64581 14.37589  1.000 26.95094 ? 390 PHE   A CD1 1 
ATOM   1693 C CD2 . PHE   A 1 272 ? 4.61443   54.01335 16.40364  1.000 28.27010 ? 390 PHE   A CD2 1 
ATOM   1694 C CE1 . PHE   A 1 272 ? 2.78159   55.58237 15.06809  1.000 25.37218 ? 390 PHE   A CE1 1 
ATOM   1695 C CE2 . PHE   A 1 272 ? 3.86332   54.93146 17.10578  1.000 29.66933 ? 390 PHE   A CE2 1 
ATOM   1696 C CZ  . PHE   A 1 272 ? 2.93907   55.72147 16.44410  1.000 29.35986 ? 390 PHE   A CZ  1 
ATOM   1697 N N   . LEU   A 1 273 ? 8.06068   54.24084 14.94162  1.000 26.77105 ? 391 LEU   A N   1 
ATOM   1698 C CA  . LEU   A 1 273 ? 8.77691   55.23454 15.73430  1.000 25.92841 ? 391 LEU   A CA  1 
ATOM   1699 C C   . LEU   A 1 273 ? 9.64512   56.12087 14.84920  1.000 24.14515 ? 391 LEU   A C   1 
ATOM   1700 O O   . LEU   A 1 273 ? 9.80606   57.31259 15.13514  1.000 26.50970 ? 391 LEU   A O   1 
ATOM   1701 C CB  . LEU   A 1 273 ? 9.63052   54.55342 16.81337  1.000 28.64449 ? 391 LEU   A CB  1 
ATOM   1702 C CG  . LEU   A 1 273 ? 8.84696   53.97603 18.00202  1.000 30.06250 ? 391 LEU   A CG  1 
ATOM   1703 C CD1 . LEU   A 1 273 ? 9.79766   53.28850 18.97295  1.000 32.56549 ? 391 LEU   A CD1 1 
ATOM   1704 C CD2 . LEU   A 1 273 ? 8.04954   55.03964 18.70588  1.000 32.61752 ? 391 LEU   A CD2 1 
ATOM   1705 N N   . LYS   A 1 274 ? 10.23237  55.55030 13.79287  1.000 24.93467 ? 392 LYS   A N   1 
ATOM   1706 C CA  . LYS   A 1 274 ? 10.98365  56.35282 12.82448  1.000 31.36277 ? 392 LYS   A CA  1 
ATOM   1707 C C   . LYS   A 1 274 ? 10.09948  57.42173 12.19097  1.000 26.92331 ? 392 LYS   A C   1 
ATOM   1708 O O   . LYS   A 1 274 ? 10.49874  58.58843 12.07498  1.000 28.02871 ? 392 LYS   A O   1 
ATOM   1709 C CB  . LYS   A 1 274 ? 11.57579  55.45803 11.73408  1.000 26.88696 ? 392 LYS   A CB  1 
ATOM   1710 C CG  . LYS   A 1 274 ? 12.82671  54.69782 12.12981  1.000 34.80036 ? 392 LYS   A CG  1 
ATOM   1711 C CD  . LYS   A 1 274 ? 13.25088  53.73796 11.02122  1.000 37.00188 ? 392 LYS   A CD  1 
ATOM   1712 C CE  . LYS   A 1 274 ? 14.40514  52.85642 11.48197  1.000 39.17359 ? 392 LYS   A CE  1 
ATOM   1713 N NZ  . LYS   A 1 274 ? 14.89887  51.99593 10.37580  1.000 39.26127 ? 392 LYS   A NZ  1 
ATOM   1714 N N   . ILE   A 1 275 ? 8.89828   57.02975 11.75088  1.000 29.60269 ? 393 ILE   A N   1 
ATOM   1715 C CA  . ILE   A 1 275 ? 7.97585   57.97807 11.12804  1.000 24.88917 ? 393 ILE   A CA  1 
ATOM   1716 C C   . ILE   A 1 275 ? 7.61032   59.07924 12.11138  1.000 28.71592 ? 393 ILE   A C   1 
ATOM   1717 O O   . ILE   A 1 275 ? 7.60407   60.26635 11.76279  1.000 23.51433 ? 393 ILE   A O   1 
ATOM   1718 C CB  . ILE   A 1 275 ? 6.72264   57.24271 10.60142  1.000 23.96413 ? 393 ILE   A CB  1 
ATOM   1719 C CG1 . ILE   A 1 275 ? 7.06989   56.37285 9.39258   1.000 21.94731 ? 393 ILE   A CG1 1 
ATOM   1720 C CG2 . ILE   A 1 275 ? 5.60732   58.24271 10.27787  1.000 25.30489 ? 393 ILE   A CG2 1 
ATOM   1721 C CD1 . ILE   A 1 275 ? 5.96525   55.37181 9.01251   1.000 26.01103 ? 393 ILE   A CD1 1 
ATOM   1722 N N   . MET   A 1 276 ? 7.32049   58.71340 13.36565  1.000 24.96088 ? 394 MET   A N   1 
ATOM   1723 C CA  . MET   A 1 276 ? 6.94115   59.73146 14.33436  1.000 24.51756 ? 394 MET   A CA  1 
ATOM   1724 C C   . MET   A 1 276 ? 8.08705   60.70618 14.59031  1.000 24.96419 ? 394 MET   A C   1 
ATOM   1725 O O   . MET   A 1 276 ? 7.86200   61.91571 14.70327  1.000 27.09007 ? 394 MET   A O   1 
ATOM   1726 C CB  . MET   A 1 276 ? 6.46079   59.08076 15.63429  1.000 29.75242 ? 394 MET   A CB  1 
ATOM   1727 C CG  . MET   A 1 276 ? 5.11748   58.28074 15.48597  1.000 31.45790 ? 394 MET   A CG  1 
ATOM   1728 S SD  . MET   A 1 276 ? 3.71358   59.17580 14.73339  1.000 32.16633 ? 394 MET   A SD  1 
ATOM   1729 C CE  . MET   A 1 276 ? 3.11508   60.16296 16.10028  1.000 32.30364 ? 394 MET   A CE  1 
ATOM   1730 N N   . ALA   A 1 277 ? 9.32470   60.20396 14.66366  1.000 28.11900 ? 395 ALA   A N   1 
ATOM   1731 C CA  . ALA   A 1 277 ? 10.46899  61.09466 14.83801  1.000 29.54872 ? 395 ALA   A CA  1 
ATOM   1732 C C   . ALA   A 1 277 ? 10.61812  62.03396 13.64299  1.000 27.70101 ? 395 ALA   A C   1 
ATOM   1733 O O   . ALA   A 1 277 ? 10.92135  63.22011 13.80629  1.000 29.22700 ? 395 ALA   A O   1 
ATOM   1734 C CB  . ALA   A 1 277 ? 11.74508  60.28108 15.04755  1.000 31.09314 ? 395 ALA   A CB  1 
ATOM   1735 N N   . MET   A 1 278 ? 10.37301  61.53151 12.43432  1.000 28.23909 ? 396 MET   A N   1 
ATOM   1736 C CA  A MET   A 1 278 ? 10.44223  62.39394 11.25935  0.749 29.58441 ? 396 MET   A CA  1 
ATOM   1737 C CA  B MET   A 1 278 ? 10.44487  62.39212 11.25746  0.251 29.48911 ? 396 MET   A CA  1 
ATOM   1738 C C   . MET   A 1 278 ? 9.37714   63.47866 11.30519  1.000 23.75482 ? 396 MET   A C   1 
ATOM   1739 O O   . MET   A 1 278 ? 9.62844   64.62053 10.90590  1.000 28.29683 ? 396 MET   A O   1 
ATOM   1740 C CB  A MET   A 1 278 ? 10.30889  61.55122 10.00083  0.749 28.75350 ? 396 MET   A CB  1 
ATOM   1741 C CB  B MET   A 1 278 ? 10.31214  61.56013 9.97973   0.251 28.90289 ? 396 MET   A CB  1 
ATOM   1742 C CG  A MET   A 1 278 ? 11.42951  60.55706 9.89396   0.749 31.36733 ? 396 MET   A CG  1 
ATOM   1743 C CG  B MET   A 1 278 ? 11.42689  60.54011 9.77758   0.251 31.37321 ? 396 MET   A CG  1 
ATOM   1744 S SD  A MET   A 1 278 ? 11.77494  60.09529 8.21515   0.749 33.07768 ? 396 MET   A SD  1 
ATOM   1745 S SD  B MET   A 1 278 ? 13.08317  61.25142 9.75958   0.251 43.52110 ? 396 MET   A SD  1 
ATOM   1746 C CE  A MET   A 1 278 ? 12.57837  61.56979 7.61078   0.749 30.38857 ? 396 MET   A CE  1 
ATOM   1747 C CE  B MET   A 1 278 ? 13.07430  62.12681 8.20270   0.251 34.28287 ? 396 MET   A CE  1 
ATOM   1748 N N   . LEU   A 1 279 ? 8.18272   63.14989 11.80459  1.000 25.87046 ? 397 LEU   A N   1 
ATOM   1749 C CA  . LEU   A 1 279 ? 7.13196   64.16918 11.88323  1.000 26.48597 ? 397 LEU   A CA  1 
ATOM   1750 C C   . LEU   A 1 279 ? 7.49898   65.25408 12.88374  1.000 30.74048 ? 397 LEU   A C   1 
ATOM   1751 O O   . LEU   A 1 279 ? 7.22122   66.43989 12.66240  1.000 26.56760 ? 397 LEU   A O   1 
ATOM   1752 C CB  . LEU   A 1 279 ? 5.78734   63.53120 12.24668  1.000 22.91993 ? 397 LEU   A CB  1 
ATOM   1753 C CG  . LEU   A 1 279 ? 5.08805   62.77063 11.09745  1.000 29.20737 ? 397 LEU   A CG  1 
ATOM   1754 C CD1 . LEU   A 1 279 ? 3.88148   61.99056 11.61094  1.000 25.25901 ? 397 LEU   A CD1 1 
ATOM   1755 C CD2 . LEU   A 1 279 ? 4.66842   63.70512 9.95462   1.000 26.69605 ? 397 LEU   A CD2 1 
ATOM   1756 N N   . THR   A 1 280 ? 8.12073   64.86342 13.99825  1.000 26.95401 ? 398 THR   A N   1 
ATOM   1757 C CA  . THR   A 1 280 ? 8.62178   65.85299 14.93493  1.000 28.69541 ? 398 THR   A CA  1 
ATOM   1758 C C   . THR   A 1 280 ? 9.65667   66.74118 14.26425  1.000 26.91973 ? 398 THR   A C   1 
ATOM   1759 O O   . THR   A 1 280 ? 9.60278   67.97045 14.38090  1.000 29.09023 ? 398 THR   A O   1 
ATOM   1760 C CB  . THR   A 1 280 ? 9.20912   65.15411 16.16299  1.000 30.18172 ? 398 THR   A CB  1 
ATOM   1761 O OG1 . THR   A 1 280 ? 8.14225   64.58118 16.91858  1.000 34.15211 ? 398 THR   A OG1 1 
ATOM   1762 C CG2 . THR   A 1 280 ? 9.95863   66.15009 17.03121  1.000 38.84370 ? 398 THR   A CG2 1 
ATOM   1763 N N   . GLU   A 1 281 ? 10.59734  66.12418 13.53939  1.000 29.45325 ? 399 GLU   A N   1 
ATOM   1764 C CA  . GLU   A 1 281 ? 11.62606  66.86970 12.82254  1.000 35.70395 ? 399 GLU   A CA  1 
ATOM   1765 C C   . GLU   A 1 281 ? 11.01419  67.78603 11.77079  1.000 37.96765 ? 399 GLU   A C   1 
ATOM   1766 O O   . GLU   A 1 281 ? 11.47667  68.91785 11.58227  1.000 35.86303 ? 399 GLU   A O   1 
ATOM   1767 C CB  . GLU   A 1 281 ? 12.61687  65.88761 12.18858  1.000 33.89261 ? 399 GLU   A CB  1 
ATOM   1768 C CG  . GLU   A 1 281 ? 13.56440  66.45184 11.12944  1.000 43.64724 ? 399 GLU   A CG  1 
ATOM   1769 C CD  . GLU   A 1 281 ? 14.73321  67.22596 11.71737  1.000 55.91497 ? 399 GLU   A CD  1 
ATOM   1770 O OE1 . GLU   A 1 281 ? 15.61826  67.65277 10.93503  1.000 56.13584 ? 399 GLU   A OE1 1 
ATOM   1771 O OE2 . GLU   A 1 281 ? 14.76989  67.40576 12.95669  1.000 55.55175 ? 399 GLU   A OE2 1 
ATOM   1772 N N   . LEU   A 1 282 ? 9.95891   67.32291 11.08657  1.000 29.35512 ? 400 LEU   A N   1 
ATOM   1773 C CA  . LEU   A 1 282 ? 9.34778   68.14240 10.04254  1.000 29.53959 ? 400 LEU   A CA  1 
ATOM   1774 C C   . LEU   A 1 282 ? 8.71923   69.39829 10.63591  1.000 28.19346 ? 400 LEU   A C   1 
ATOM   1775 O O   . LEU   A 1 282 ? 8.78424   70.48000 10.04184  1.000 29.49040 ? 400 LEU   A O   1 
ATOM   1776 C CB  . LEU   A 1 282 ? 8.31566   67.31373 9.26917   1.000 24.80618 ? 400 LEU   A CB  1 
ATOM   1777 C CG  . LEU   A 1 282 ? 7.56928   67.95581 8.09729   1.000 26.41062 ? 400 LEU   A CG  1 
ATOM   1778 C CD1 . LEU   A 1 282 ? 8.53955   68.52621 7.08379   1.000 26.67799 ? 400 LEU   A CD1 1 
ATOM   1779 C CD2 . LEU   A 1 282 ? 6.59727   66.92502 7.46984   1.000 20.50069 ? 400 LEU   A CD2 1 
ATOM   1780 N N   . ARG   A 1 283 ? 8.13073   69.28483 11.82806  1.000 31.42826 ? 401 ARG   A N   1 
ATOM   1781 C CA  A ARG   A 1 283 ? 7.55977   70.46011 12.47802  0.531 31.63140 ? 401 ARG   A CA  1 
ATOM   1782 C CA  B ARG   A 1 283 ? 7.56272   70.46136 12.47258  0.469 31.92075 ? 401 ARG   A CA  1 
ATOM   1783 C C   . ARG   A 1 283 ? 8.64841   71.46544 12.84119  1.000 32.48485 ? 401 ARG   A C   1 
ATOM   1784 O O   . ARG   A 1 283 ? 8.44078   72.67839 12.74862  1.000 33.79876 ? 401 ARG   A O   1 
ATOM   1785 C CB  A ARG   A 1 283 ? 6.76114   70.03667 13.71744  0.531 37.24006 ? 401 ARG   A CB  1 
ATOM   1786 C CB  B ARG   A 1 283 ? 6.77251   70.04760 13.71060  0.469 37.26628 ? 401 ARG   A CB  1 
ATOM   1787 C CG  A ARG   A 1 283 ? 6.27734   71.19692 14.57875  0.531 39.42510 ? 401 ARG   A CG  1 
ATOM   1788 C CG  B ARG   A 1 283 ? 6.42909   71.21873 14.58771  0.469 39.39277 ? 401 ARG   A CG  1 
ATOM   1789 C CD  A ARG   A 1 283 ? 5.04685   70.83476 15.42966  0.531 40.15839 ? 401 ARG   A CD  1 
ATOM   1790 C CD  B ARG   A 1 283 ? 5.65053   70.79994 15.80776  0.469 41.50699 ? 401 ARG   A CD  1 
ATOM   1791 N NE  A ARG   A 1 283 ? 5.04240   69.44167 15.86533  0.531 41.62350 ? 401 ARG   A NE  1 
ATOM   1792 N NE  B ARG   A 1 283 ? 4.99889   71.95167 16.41659  0.469 38.92427 ? 401 ARG   A NE  1 
ATOM   1793 C CZ  A ARG   A 1 283 ? 5.58433   69.00549 16.99910  0.531 43.53784 ? 401 ARG   A CZ  1 
ATOM   1794 C CZ  B ARG   A 1 283 ? 3.75412   71.92614 16.86175  0.469 42.40496 ? 401 ARG   A CZ  1 
ATOM   1795 N NH1 A ARG   A 1 283 ? 6.18579   69.85495 17.82137  0.531 40.05792 ? 401 ARG   A NH1 1 
ATOM   1796 N NH1 B ARG   A 1 283 ? 3.05772   70.80547 16.75269  0.469 43.57143 ? 401 ARG   A NH1 1 
ATOM   1797 N NH2 A ARG   A 1 283 ? 5.52938   67.71493 17.30980  0.531 44.33639 ? 401 ARG   A NH2 1 
ATOM   1798 N NH2 B ARG   A 1 283 ? 3.20372   73.00513 17.40659  0.469 43.65895 ? 401 ARG   A NH2 1 
ATOM   1799 N N   . SER   A 1 284 ? 9.81432   70.98086 13.26087  1.000 33.71050 ? 402 SER   A N   1 
ATOM   1800 C CA  . SER   A 1 284 ? 10.91059  71.88944 13.57775  1.000 36.66580 ? 402 SER   A CA  1 
ATOM   1801 C C   . SER   A 1 284 ? 11.41213  72.59945 12.31712  1.000 34.12801 ? 402 SER   A C   1 
ATOM   1802 O O   . SER   A 1 284 ? 11.61462  73.82068 12.31918  1.000 37.94110 ? 402 SER   A O   1 
ATOM   1803 C CB  . SER   A 1 284 ? 12.02834  71.10707 14.26725  1.000 36.95275 ? 402 SER   A CB  1 
ATOM   1804 O OG  . SER   A 1 284 ? 13.15680  71.91352 14.47972  1.000 45.38545 ? 402 SER   A OG  1 
ATOM   1805 N N   . ILE   A 1 285 ? 11.56333  71.85759 11.21951  1.000 34.08748 ? 403 ILE   A N   1 
ATOM   1806 C CA  . ILE   A 1 285 ? 11.95613  72.45102 9.94042   1.000 30.25831 ? 403 ILE   A CA  1 
ATOM   1807 C C   . ILE   A 1 285 ? 10.93254  73.48512 9.47885   1.000 34.46373 ? 403 ILE   A C   1 
ATOM   1808 O O   . ILE   A 1 285 ? 11.29080  74.54020 8.93700   1.000 36.08840 ? 403 ILE   A O   1 
ATOM   1809 C CB  . ILE   A 1 285 ? 12.13658  71.34092 8.89531   1.000 36.14669 ? 403 ILE   A CB  1 
ATOM   1810 C CG1 . ILE   A 1 285 ? 13.27450  70.40725 9.31350   1.000 39.03444 ? 403 ILE   A CG1 1 
ATOM   1811 C CG2 . ILE   A 1 285 ? 12.34068  71.93906 7.50272   1.000 34.29541 ? 403 ILE   A CG2 1 
ATOM   1812 C CD1 . ILE   A 1 285 ? 13.36810  69.18300 8.43419   1.000 37.08347 ? 403 ILE   A CD1 1 
ATOM   1813 N N   . ASN   A 1 286 ? 9.64372   73.18040 9.65384   1.000 29.17130 ? 404 ASN   A N   1 
ATOM   1814 C CA  . ASN   A 1 286 ? 8.57902   74.12239 9.32841   1.000 30.25622 ? 404 ASN   A CA  1 
ATOM   1815 C C   . ASN   A 1 286 ? 8.80789   75.46836 10.00973  1.000 33.48067 ? 404 ASN   A C   1 
ATOM   1816 O O   . ASN   A 1 286 ? 8.68043   76.52289 9.37674   1.000 30.93182 ? 404 ASN   A O   1 
ATOM   1817 C CB  . ASN   A 1 286 ? 7.23201   73.50864 9.73275   1.000 28.15326 ? 404 ASN   A CB  1 
ATOM   1818 C CG  . ASN   A 1 286 ? 6.02526   74.38839 9.39198   1.000 30.92851 ? 404 ASN   A CG  1 
ATOM   1819 O OD1 . ASN   A 1 286 ? 6.13151   75.40504 8.70170   1.000 30.94502 ? 404 ASN   A OD1 1 
ATOM   1820 N ND2 . ASN   A 1 286 ? 4.85385   73.97903 9.88155   1.000 32.72525 ? 404 ASN   A ND2 1 
ATOM   1821 N N   . ALA   A 1 287 ? 9.16201   75.45477 11.29656  1.000 32.63717 ? 405 ALA   A N   1 
ATOM   1822 C CA  . ALA   A 1 287 ? 9.43472   76.70941 11.99123  1.000 34.13331 ? 405 ALA   A CA  1 
ATOM   1823 C C   . ALA   A 1 287 ? 10.62242  77.44438 11.37074  1.000 35.95033 ? 405 ALA   A C   1 
ATOM   1824 O O   . ALA   A 1 287 ? 10.56339  78.66263 11.16970  1.000 38.01402 ? 405 ALA   A O   1 
ATOM   1825 C CB  . ALA   A 1 287 ? 9.67303   76.44931 13.47946  1.000 33.57999 ? 405 ALA   A CB  1 
ATOM   1826 N N   . GLN   A 1 288 ? 11.71071  76.72643 11.06057  1.000 31.70276 ? 406 GLN   A N   1 
ATOM   1827 C CA  . GLN   A 1 288 ? 12.87361  77.37148 10.45071  1.000 32.71172 ? 406 GLN   A CA  1 
ATOM   1828 C C   . GLN   A 1 288 ? 12.52894  77.93793 9.07396   1.000 36.21264 ? 406 GLN   A C   1 
ATOM   1829 O O   . GLN   A 1 288 ? 12.88680  79.07548 8.74701   1.000 37.36235 ? 406 GLN   A O   1 
ATOM   1830 C CB  . GLN   A 1 288 ? 14.03689  76.38357 10.33801  1.000 38.90986 ? 406 GLN   A CB  1 
ATOM   1831 C CG  . GLN   A 1 288 ? 14.57028  75.84932 11.67567  1.000 52.25570 ? 406 GLN   A CG  1 
ATOM   1832 C CD  . GLN   A 1 288 ? 15.57605  74.70409 11.50769  1.000 58.91796 ? 406 GLN   A CD  1 
ATOM   1833 O OE1 . GLN   A 1 288 ? 15.22119  73.59101 11.09714  1.000 56.99700 ? 406 GLN   A OE1 1 
ATOM   1834 N NE2 . GLN   A 1 288 ? 16.83753  74.97826 11.82786  1.000 66.05029 ? 406 GLN   A NE2 1 
ATOM   1835 N N   . HIS   A 1 289 ? 11.82121  77.16344 8.25115   1.000 33.09237 ? 407 HIS   A N   1 
ATOM   1836 C CA  . HIS   A 1 289 ? 11.52638  77.64036 6.90170   1.000 28.94631 ? 407 HIS   A CA  1 
ATOM   1837 C C   . HIS   A 1 289 ? 10.47530  78.74482 6.89674   1.000 32.90001 ? 407 HIS   A C   1 
ATOM   1838 O O   . HIS   A 1 289 ? 10.49044  79.60832 6.00793   1.000 32.73327 ? 407 HIS   A O   1 
ATOM   1839 C CB  . HIS   A 1 289 ? 11.09338  76.47467 6.02067   1.000 32.78759 ? 407 HIS   A CB  1 
ATOM   1840 C CG  . HIS   A 1 289 ? 12.23661  75.63591 5.55261   1.000 41.38772 ? 407 HIS   A CG  1 
ATOM   1841 N ND1 . HIS   A 1 289 ? 12.50751  75.42471 4.21912   1.000 43.88566 ? 407 HIS   A ND1 1 
ATOM   1842 C CD2 . HIS   A 1 289 ? 13.20655  74.98810 6.24207   1.000 40.61382 ? 407 HIS   A CD2 1 
ATOM   1843 C CE1 . HIS   A 1 289 ? 13.58194  74.66246 4.10661   1.000 47.81694 ? 407 HIS   A CE1 1 
ATOM   1844 N NE2 . HIS   A 1 289 ? 14.02280  74.38083 5.32025   1.000 41.98777 ? 407 HIS   A NE2 1 
ATOM   1845 N N   . THR   A 1 290 ? 9.55472   78.73997 7.86454   1.000 30.09526 ? 408 THR   A N   1 
ATOM   1846 C CA  . THR   A 1 290 ? 8.61550   79.84977 7.97597   1.000 29.15609 ? 408 THR   A CA  1 
ATOM   1847 C C   . THR   A 1 290 ? 9.35799   81.15007 8.27203   1.000 33.79786 ? 408 THR   A C   1 
ATOM   1848 O O   . THR   A 1 290 ? 9.01387   82.20834 7.73263   1.000 31.89687 ? 408 THR   A O   1 
ATOM   1849 C CB  . THR   A 1 290 ? 7.56723   79.54898 9.05705   1.000 36.73010 ? 408 THR   A CB  1 
ATOM   1850 O OG1 . THR   A 1 290 ? 6.69254   78.50582 8.60097   1.000 35.49979 ? 408 THR   A OG1 1 
ATOM   1851 C CG2 . THR   A 1 290 ? 6.72903   80.79836 9.39917   1.000 33.19173 ? 408 THR   A CG2 1 
ATOM   1852 N N   . GLN   A 1 291 ? 10.38980  81.08591 9.11945   1.000 32.15706 ? 409 GLN   A N   1 
ATOM   1853 C CA  A GLN   A 1 291 ? 11.19952  82.27190 9.37886   0.726 35.78306 ? 409 GLN   A CA  1 
ATOM   1854 C C   . GLN   A 1 291 ? 12.00730  82.67875 8.15083   1.000 35.61827 ? 409 GLN   A C   1 
ATOM   1855 O O   . GLN   A 1 291 ? 12.13962  83.87265 7.86358   1.000 38.31231 ? 409 GLN   A O   1 
ATOM   1856 C CB  A GLN   A 1 291 ? 12.11177  82.03445 10.57906  0.726 34.25937 ? 409 GLN   A CB  1 
ATOM   1857 C CG  A GLN   A 1 291 ? 11.35841  82.07188 11.89648  0.726 40.73314 ? 409 GLN   A CG  1 
ATOM   1858 C CD  A GLN   A 1 291 ? 10.35434  83.21916 11.96544  0.726 43.91677 ? 409 GLN   A CD  1 
ATOM   1859 O OE1 A GLN   A 1 291 ? 10.72537  84.39414 11.87160  0.726 41.98406 ? 409 GLN   A OE1 1 
ATOM   1860 N NE2 A GLN   A 1 291 ? 9.07325   82.88029 12.13350  0.726 35.20964 ? 409 GLN   A NE2 1 
ATOM   1861 N N   . ARG   A 1 292 ? 12.55903  81.71206 7.41097   1.000 36.15782 ? 410 ARG   A N   1 
ATOM   1862 C CA  . ARG   A 1 292 ? 13.25018  82.06244 6.17188   1.000 38.89116 ? 410 ARG   A CA  1 
ATOM   1863 C C   . ARG   A 1 292 ? 12.31638  82.77811 5.20900   1.000 37.76698 ? 410 ARG   A C   1 
ATOM   1864 O O   . ARG   A 1 292 ? 12.70018  83.77463 4.58509   1.000 35.06153 ? 410 ARG   A O   1 
ATOM   1865 C CB  . ARG   A 1 292 ? 13.82249  80.82131 5.49699   1.000 41.24888 ? 410 ARG   A CB  1 
ATOM   1866 C CG  . ARG   A 1 292 ? 14.98647  80.19138 6.20649   1.000 47.04217 ? 410 ARG   A CG  1 
ATOM   1867 C CD  . ARG   A 1 292 ? 15.52582  79.03228 5.37304   1.000 53.72281 ? 410 ARG   A CD  1 
ATOM   1868 N NE  . ARG   A 1 292 ? 16.31628  78.11088 6.18144   1.000 52.48093 ? 410 ARG   A NE  1 
ATOM   1869 C CZ  . ARG   A 1 292 ? 17.07089  77.14011 5.68237   1.000 55.29788 ? 410 ARG   A CZ  1 
ATOM   1870 N NH1 . ARG   A 1 292 ? 17.13432  76.95265 4.36788   1.000 57.54917 ? 410 ARG   A NH1 1 
ATOM   1871 N NH2 . ARG   A 1 292 ? 17.76221  76.35549 6.50057   1.000 60.72780 ? 410 ARG   A NH2 1 
ATOM   1872 N N   . LEU   A 1 293 ? 11.08656  82.27850 5.06738   1.000 33.35008 ? 411 LEU   A N   1 
ATOM   1873 C CA  . LEU   A 1 293 ? 10.13831  82.90859 4.15679   1.000 37.97613 ? 411 LEU   A CA  1 
ATOM   1874 C C   . LEU   A 1 293 ? 9.88503   84.34708 4.57004   1.000 28.95431 ? 411 LEU   A C   1 
ATOM   1875 O O   . LEU   A 1 293 ? 9.89621   85.25137 3.73521   1.000 32.37380 ? 411 LEU   A O   1 
ATOM   1876 C CB  . LEU   A 1 293 ? 8.82132   82.12295 4.11704   1.000 34.64896 ? 411 LEU   A CB  1 
ATOM   1877 C CG  . LEU   A 1 293 ? 7.74388   82.58450 3.11591   1.000 38.75957 ? 411 LEU   A CG  1 
ATOM   1878 C CD1 . LEU   A 1 293 ? 6.91560   81.39772 2.64130   1.000 34.68852 ? 411 LEU   A CD1 1 
ATOM   1879 C CD2 . LEU   A 1 293 ? 6.81942   83.64148 3.72435   1.000 37.35041 ? 411 LEU   A CD2 1 
ATOM   1880 N N   . LEU   A 1 294 ? 9.66397   84.57400 5.86529   1.000 37.04106 ? 412 LEU   A N   1 
ATOM   1881 C CA  . LEU   A 1 294 ? 9.32631   85.91394 6.33060   1.000 37.89012 ? 412 LEU   A CA  1 
ATOM   1882 C C   . LEU   A 1 294 ? 10.48724  86.88745 6.14086   1.000 37.00064 ? 412 LEU   A C   1 
ATOM   1883 O O   . LEU   A 1 294 ? 10.25410  88.06682 5.85762   1.000 41.85383 ? 412 LEU   A O   1 
ATOM   1884 C CB  . LEU   A 1 294 ? 8.89504   85.86699 7.79806   1.000 36.74917 ? 412 LEU   A CB  1 
ATOM   1885 C CG  . LEU   A 1 294 ? 7.62862   85.08979 8.18223   1.000 37.46339 ? 412 LEU   A CG  1 
ATOM   1886 C CD1 . LEU   A 1 294 ? 7.23228   85.41987 9.60685   1.000 45.33198 ? 412 LEU   A CD1 1 
ATOM   1887 C CD2 . LEU   A 1 294 ? 6.47332   85.39407 7.24310   1.000 37.40477 ? 412 LEU   A CD2 1 
ATOM   1888 N N   . ARG   A 1 295 ? 11.73493  86.42291 6.28690   1.000 35.50713 ? 413 ARG   A N   1 
ATOM   1889 C CA  . ARG   A 1 295 ? 12.87908  87.30793 6.05956   1.000 41.41324 ? 413 ARG   A CA  1 
ATOM   1890 C C   . ARG   A 1 295 ? 12.98621  87.70892 4.59592   1.000 40.35472 ? 413 ARG   A C   1 
ATOM   1891 O O   . ARG   A 1 295 ? 13.18306  88.88934 4.28046   1.000 40.43270 ? 413 ARG   A O   1 
ATOM   1892 C CB  . ARG   A 1 295 ? 14.17883  86.65256 6.52471   1.000 39.61659 ? 413 ARG   A CB  1 
ATOM   1893 C CG  . ARG   A 1 295 ? 14.29018  86.55173 8.03662   1.000 49.69261 ? 413 ARG   A CG  1 
ATOM   1894 C CD  . ARG   A 1 295 ? 15.71027  86.20585 8.47142   1.000 55.55192 ? 413 ARG   A CD  1 
ATOM   1895 N NE  . ARG   A 1 295 ? 16.14443  84.91425 7.94338   1.000 60.26644 ? 413 ARG   A NE  1 
ATOM   1896 C CZ  . ARG   A 1 295 ? 16.10382  83.77913 8.63699   1.000 57.67057 ? 413 ARG   A CZ  1 
ATOM   1897 N NH1 . ARG   A 1 295 ? 15.63810  83.78337 9.88017   1.000 52.61807 ? 413 ARG   A NH1 1 
ATOM   1898 N NH2 . ARG   A 1 295 ? 16.51258  82.64115 8.08637   1.000 54.46891 ? 413 ARG   A NH2 1 
ATOM   1899 N N   . ILE   A 1 296 ? 12.86624  86.73875 3.68380   1.000 39.15304 ? 414 ILE   A N   1 
ATOM   1900 C CA  . ILE   A 1 296 ? 12.94182  87.05229 2.25936   1.000 38.23629 ? 414 ILE   A CA  1 
ATOM   1901 C C   . ILE   A 1 296 ? 11.78968  87.95917 1.84931   1.000 38.72962 ? 414 ILE   A C   1 
ATOM   1902 O O   . ILE   A 1 296 ? 11.98569  88.94097 1.12220   1.000 36.28544 ? 414 ILE   A O   1 
ATOM   1903 C CB  . ILE   A 1 296 ? 12.96532  85.76147 1.42211   1.000 37.53062 ? 414 ILE   A CB  1 
ATOM   1904 C CG1 . ILE   A 1 296 ? 14.26622  84.99866 1.66392   1.000 36.41722 ? 414 ILE   A CG1 1 
ATOM   1905 C CG2 . ILE   A 1 296 ? 12.78013  86.08247 -0.05323  1.000 40.55596 ? 414 ILE   A CG2 1 
ATOM   1906 C CD1 . ILE   A 1 296 ? 14.24188  83.59575 1.13750   1.000 42.40040 ? 414 ILE   A CD1 1 
ATOM   1907 N N   . GLN   A 1 297 ? 10.57157  87.64095 2.30384   1.000 37.34050 ? 415 GLN   A N   1 
ATOM   1908 C CA  . GLN   A 1 297 ? 9.42013   88.50720 2.05483   1.000 38.57380 ? 415 GLN   A CA  1 
ATOM   1909 C C   . GLN   A 1 297 ? 9.67531   89.93707 2.52570   1.000 41.55827 ? 415 GLN   A C   1 
ATOM   1910 O O   . GLN   A 1 297 ? 9.23427   90.89874 1.88720   1.000 40.14026 ? 415 GLN   A O   1 
ATOM   1911 C CB  . GLN   A 1 297 ? 8.18336   87.94912 2.75573   1.000 32.66834 ? 415 GLN   A CB  1 
ATOM   1912 C CG  . GLN   A 1 297 ? 6.94145   88.84175 2.62608   1.000 36.82985 ? 415 GLN   A CG  1 
ATOM   1913 C CD  . GLN   A 1 297 ? 6.29046   88.75429 1.25726   1.000 34.07710 ? 415 GLN   A CD  1 
ATOM   1914 O OE1 . GLN   A 1 297 ? 6.69755   87.95533 0.40861   1.000 33.76623 ? 415 GLN   A OE1 1 
ATOM   1915 N NE2 . GLN   A 1 297 ? 5.25608   89.55649 1.04086   1.000 37.32565 ? 415 GLN   A NE2 1 
ATOM   1916 N N   . ASP   A 1 298 ? 10.37001  90.09663 3.65215   1.000 41.05108 ? 416 ASP   A N   1 
ATOM   1917 C CA  . ASP   A 1 298 ? 10.60343  91.43608 4.18795   1.000 46.35519 ? 416 ASP   A CA  1 
ATOM   1918 C C   . ASP   A 1 298 ? 11.42514  92.28819 3.22213   1.000 48.87982 ? 416 ASP   A C   1 
ATOM   1919 O O   . ASP   A 1 298 ? 11.12352  93.46988 3.01244   1.000 53.58668 ? 416 ASP   A O   1 
ATOM   1920 C CB  . ASP   A 1 298 ? 11.28276  91.33311 5.55652   1.000 45.68202 ? 416 ASP   A CB  1 
ATOM   1921 C CG  . ASP   A 1 298 ? 11.39969  92.67149 6.25532   1.000 62.29197 ? 416 ASP   A CG  1 
ATOM   1922 O OD1 . ASP   A 1 298 ? 10.39227  93.40778 6.30312   1.000 64.27429 ? 416 ASP   A OD1 1 
ATOM   1923 O OD2 . ASP   A 1 298 ? 12.49529  92.97775 6.77310   1.000 68.27993 ? 416 ASP   A OD2 1 
ATOM   1924 N N   . ILE   A 1 299 ? 12.44192  91.69905 2.59131   1.000 44.80400 ? 417 ILE   A N   1 
ATOM   1925 C CA  . ILE   A 1 299 ? 13.31818  92.45355 1.69709   1.000 49.95628 ? 417 ILE   A CA  1 
ATOM   1926 C C   . ILE   A 1 299 ? 12.94348  92.31858 0.22850   1.000 48.47003 ? 417 ILE   A C   1 
ATOM   1927 O O   . ILE   A 1 299 ? 13.39294  93.13816 -0.58995  1.000 50.71658 ? 417 ILE   A O   1 
ATOM   1928 C CB  . ILE   A 1 299 ? 14.78940  92.04016 1.89353   1.000 47.34700 ? 417 ILE   A CB  1 
ATOM   1929 C CG1 . ILE   A 1 299 ? 14.99296  90.59540 1.43940   1.000 48.56365 ? 417 ILE   A CG1 1 
ATOM   1930 C CG2 . ILE   A 1 299 ? 15.19744  92.21788 3.35100   1.000 52.61977 ? 417 ILE   A CG2 1 
ATOM   1931 C CD1 . ILE   A 1 299 ? 16.43823  90.17122 1.42502   1.000 56.11525 ? 417 ILE   A CD1 1 
ATOM   1932 N N   . HIS   A 1 300 ? 12.13916  91.32908 -0.13406  1.000 42.73052 ? 418 HIS   A N   1 
ATOM   1933 C CA  . HIS   A 1 300 ? 11.79957  91.07738 -1.52716  1.000 37.89643 ? 418 HIS   A CA  1 
ATOM   1934 C C   . HIS   A 1 300 ? 10.43387  90.39527 -1.60181  1.000 44.65279 ? 418 HIS   A C   1 
ATOM   1935 O O   . HIS   A 1 300 ? 10.35967  89.15708 -1.63641  1.000 40.03121 ? 418 HIS   A O   1 
ATOM   1936 C CB  . HIS   A 1 300 ? 12.88467  90.22270 -2.18199  1.000 43.41655 ? 418 HIS   A CB  1 
ATOM   1937 C CG  . HIS   A 1 300 ? 12.66048  89.96855 -3.63909  1.000 50.17230 ? 418 HIS   A CG  1 
ATOM   1938 N ND1 . HIS   A 1 300 ? 12.91572  90.91336 -4.60929  1.000 48.27043 ? 418 HIS   A ND1 1 
ATOM   1939 C CD2 . HIS   A 1 300 ? 12.19461  88.87722 -4.29080  1.000 48.61814 ? 418 HIS   A CD2 1 
ATOM   1940 C CE1 . HIS   A 1 300 ? 12.61994  90.41493 -5.79606  1.000 48.41610 ? 418 HIS   A CE1 1 
ATOM   1941 N NE2 . HIS   A 1 300 ? 12.18115  89.18046 -5.63052  1.000 47.86441 ? 418 HIS   A NE2 1 
ATOM   1942 N N   . PRO   A 1 301 ? 9.34156   91.16612 -1.61344  1.000 38.05131 ? 419 PRO   A N   1 
ATOM   1943 C CA  . PRO   A 1 301 ? 7.99771   90.56630 -1.56639  1.000 38.95785 ? 419 PRO   A CA  1 
ATOM   1944 C C   . PRO   A 1 301 ? 7.75554   89.59542 -2.71347  1.000 38.60290 ? 419 PRO   A C   1 
ATOM   1945 O O   . PRO   A 1 301 ? 8.08193   89.87592 -3.87110  1.000 39.40512 ? 419 PRO   A O   1 
ATOM   1946 C CB  . PRO   A 1 301 ? 7.06405   91.77993 -1.65971  1.000 39.39407 ? 419 PRO   A CB  1 
ATOM   1947 C CG  . PRO   A 1 301 ? 7.88348   92.93548 -1.20544  1.000 39.06811 ? 419 PRO   A CG  1 
ATOM   1948 C CD  . PRO   A 1 301 ? 9.29627   92.63884 -1.61604  1.000 43.13001 ? 419 PRO   A CD  1 
ATOM   1949 N N   . PHE   A 1 302 ? 7.17272   88.43564 -2.37821  1.000 33.68809 ? 420 PHE   A N   1 
ATOM   1950 C CA  . PHE   A 1 302 ? 6.89777   87.41396 -3.38735  1.000 35.70904 ? 420 PHE   A CA  1 
ATOM   1951 C C   . PHE   A 1 302 ? 5.70573   86.52294 -3.04352  1.000 32.53894 ? 420 PHE   A C   1 
ATOM   1952 O O   . PHE   A 1 302 ? 5.18491   85.83949 -3.92955  1.000 29.68867 ? 420 PHE   A O   1 
ATOM   1953 C CB  . PHE   A 1 302 ? 8.13927   86.53772 -3.60787  1.000 33.03914 ? 420 PHE   A CB  1 
ATOM   1954 C CG  . PHE   A 1 302 ? 8.39261   85.54720 -2.49869  1.000 34.22114 ? 420 PHE   A CG  1 
ATOM   1955 C CD1 . PHE   A 1 302 ? 8.94948   85.95903 -1.29310  1.000 31.80709 ? 420 PHE   A CD1 1 
ATOM   1956 C CD2 . PHE   A 1 302 ? 8.08899   84.20104 -2.66998  1.000 35.27509 ? 420 PHE   A CD2 1 
ATOM   1957 C CE1 . PHE   A 1 302 ? 9.19756   85.04983 -0.27173  1.000 33.99617 ? 420 PHE   A CE1 1 
ATOM   1958 C CE2 . PHE   A 1 302 ? 8.32820   83.28807 -1.65211  1.000 35.57882 ? 420 PHE   A CE2 1 
ATOM   1959 C CZ  . PHE   A 1 302 ? 8.88312   83.71642 -0.45078  1.000 37.42417 ? 420 PHE   A CZ  1 
ATOM   1960 N N   . ALA   A 1 303 ? 5.27271   86.51366 -1.77907  1.000 29.23580 ? 421 ALA   A N   1 
ATOM   1961 C CA  . ALA   A 1 303 ? 4.21139   85.60752 -1.34103  1.000 30.36248 ? 421 ALA   A CA  1 
ATOM   1962 C C   . ALA   A 1 303 ? 2.88579   85.93735 -2.02460  1.000 30.55951 ? 421 ALA   A C   1 
ATOM   1963 O O   . ALA   A 1 303 ? 2.46995   87.09220 -2.06430  1.000 28.69027 ? 421 ALA   A O   1 
ATOM   1964 C CB  . ALA   A 1 303 ? 4.04709   85.68242 0.18011   1.000 26.84904 ? 421 ALA   A CB  1 
ATOM   1965 N N   . THR   A 1 304 ? 2.22221   84.92744 -2.57386  1.000 28.92987 ? 422 THR   A N   1 
ATOM   1966 C CA  . THR   A 1 304 ? 0.88104   85.14228 -3.08972  1.000 25.23463 ? 422 THR   A CA  1 
ATOM   1967 C C   . THR   A 1 304 ? -0.06406  85.48381 -1.93219  1.000 26.58868 ? 422 THR   A C   1 
ATOM   1968 O O   . THR   A 1 304 ? 0.26541   85.25945 -0.75497  1.000 24.64927 ? 422 THR   A O   1 
ATOM   1969 C CB  . THR   A 1 304 ? 0.37783   83.89760 -3.82236  1.000 29.54240 ? 422 THR   A CB  1 
ATOM   1970 O OG1 . THR   A 1 304 ? 0.35546   82.79338 -2.90919  1.000 27.74188 ? 422 THR   A OG1 1 
ATOM   1971 C CG2 . THR   A 1 304 ? 1.26348   83.55165 -5.04413  1.000 27.63886 ? 422 THR   A CG2 1 
ATOM   1972 N N   . PRO   A 1 305 ? -1.25474  86.00791 -2.24210  1.000 27.78976 ? 423 PRO   A N   1 
ATOM   1973 C CA  . PRO   A 1 305 ? -2.26188  86.19835 -1.18198  1.000 27.87448 ? 423 PRO   A CA  1 
ATOM   1974 C C   . PRO   A 1 305 ? -2.53456  84.94401 -0.36349  1.000 28.74156 ? 423 PRO   A C   1 
ATOM   1975 O O   . PRO   A 1 305 ? -2.59578  85.02694 0.86673   1.000 28.41799 ? 423 PRO   A O   1 
ATOM   1976 C CB  . PRO   A 1 305 ? -3.50109  86.64619 -1.96839  1.000 29.26960 ? 423 PRO   A CB  1 
ATOM   1977 C CG  . PRO   A 1 305 ? -2.90708  87.40544 -3.15814  1.000 31.58533 ? 423 PRO   A CG  1 
ATOM   1978 C CD  . PRO   A 1 305 ? -1.70487  86.57441 -3.53624  1.000 28.32659 ? 423 PRO   A CD  1 
ATOM   1979 N N   . LEU   A 1 306 ? -2.70124  83.78208 -1.00271  1.000 27.06116 ? 424 LEU   A N   1 
ATOM   1980 C CA  . LEU   A 1 306 ? -2.93814  82.57362 -0.21944  1.000 27.07842 ? 424 LEU   A CA  1 
ATOM   1981 C C   . LEU   A 1 306 ? -1.74327  82.26077 0.66770   1.000 25.23962 ? 424 LEU   A C   1 
ATOM   1982 O O   . LEU   A 1 306 ? -1.91124  81.84485 1.81705   1.000 26.82554 ? 424 LEU   A O   1 
ATOM   1983 C CB  . LEU   A 1 306 ? -3.27154  81.38691 -1.13191  1.000 27.29396 ? 424 LEU   A CB  1 
ATOM   1984 C CG  . LEU   A 1 306 ? -3.54570  80.06556 -0.38570  1.000 28.72736 ? 424 LEU   A CG  1 
ATOM   1985 C CD1 . LEU   A 1 306 ? -4.68365  80.21827 0.65534   1.000 27.68123 ? 424 LEU   A CD1 1 
ATOM   1986 C CD2 . LEU   A 1 306 ? -3.86314  78.91838 -1.34912  1.000 32.74098 ? 424 LEU   A CD2 1 
ATOM   1987 N N   . MET   A 1 307 ? -0.52038  82.46505 0.16047   1.000 28.33553 ? 425 MET   A N   1 
ATOM   1988 C CA  . MET   A 1 307 ? 0.64458   82.26285 1.02162   1.000 26.02394 ? 425 MET   A CA  1 
ATOM   1989 C C   . MET   A 1 307 ? 0.66426   83.25601 2.17431   1.000 25.81305 ? 425 MET   A C   1 
ATOM   1990 O O   . MET   A 1 307 ? 1.06069   82.90733 3.28948   1.000 27.18433 ? 425 MET   A O   1 
ATOM   1991 C CB  . MET   A 1 307 ? 1.95260   82.36939 0.23538   1.000 27.44106 ? 425 MET   A CB  1 
ATOM   1992 C CG  . MET   A 1 307 ? 2.31493   81.14100 -0.57265  1.000 28.24493 ? 425 MET   A CG  1 
ATOM   1993 S SD  . MET   A 1 307 ? 3.48145   81.55026 -1.88430  1.000 28.73933 ? 425 MET   A SD  1 
ATOM   1994 C CE  . MET   A 1 307 ? 4.95121   81.49993 -0.86800  1.000 28.35961 ? 425 MET   A CE  1 
ATOM   1995 N N   . GLN   A 1 308 ? 0.29124   84.51603 1.91522   1.000 27.88109 ? 426 GLN   A N   1 
ATOM   1996 C CA  . GLN   A 1 308 ? 0.25580   85.51193 2.98352   1.000 30.84211 ? 426 GLN   A CA  1 
ATOM   1997 C C   . GLN   A 1 308 ? -0.70430  85.08246 4.08198   1.000 30.96055 ? 426 GLN   A C   1 
ATOM   1998 O O   . GLN   A 1 308 ? -0.38495  85.16472 5.27491   1.000 30.27242 ? 426 GLN   A O   1 
ATOM   1999 C CB  . GLN   A 1 308 ? -0.15342  86.87649 2.42505   1.000 29.08865 ? 426 GLN   A CB  1 
ATOM   2000 C CG  . GLN   A 1 308 ? 0.86674   87.49400 1.49277   1.000 28.78380 ? 426 GLN   A CG  1 
ATOM   2001 C CD  . GLN   A 1 308 ? 0.34519   88.74544 0.85285   1.000 31.10142 ? 426 GLN   A CD  1 
ATOM   2002 O OE1 . GLN   A 1 308 ? -0.19223  89.61054 1.52598   1.000 27.59686 ? 426 GLN   A OE1 1 
ATOM   2003 N NE2 . GLN   A 1 308 ? 0.47198   88.83643 -0.46009  1.000 27.75579 ? 426 GLN   A NE2 1 
ATOM   2004 N N   . GLU   A 1 309 ? -1.88654  84.60821 3.68123   1.000 30.09592 ? 427 GLU   A N   1 
ATOM   2005 C CA  . GLU   A 1 309 ? -2.89250  84.14847 4.63463   1.000 33.61490 ? 427 GLU   A CA  1 
ATOM   2006 C C   . GLU   A 1 309 ? -2.37002  82.98208 5.46902   1.000 31.94352 ? 427 GLU   A C   1 
ATOM   2007 O O   . GLU   A 1 309 ? -2.52135  82.96230 6.69459   1.000 28.66257 ? 427 GLU   A O   1 
ATOM   2008 C CB  . GLU   A 1 309 ? -4.16797  83.76322 3.87294   1.000 31.40949 ? 427 GLU   A CB  1 
ATOM   2009 C CG  . GLU   A 1 309 ? -5.40354  83.54626 4.73848   1.000 43.08539 ? 427 GLU   A CG  1 
ATOM   2010 C CD  . GLU   A 1 309 ? -5.95183  84.84117 5.33633   1.000 52.10329 ? 427 GLU   A CD  1 
ATOM   2011 O OE1 . GLU   A 1 309 ? -5.68635  85.93056 4.77985   1.000 49.61199 ? 427 GLU   A OE1 1 
ATOM   2012 O OE2 . GLU   A 1 309 ? -6.64064  84.76222 6.37746   1.000 53.80956 ? 427 GLU   A OE2 1 
ATOM   2013 N N   . LEU   A 1 310 ? -1.73109  82.00408 4.81447   1.000 29.83928 ? 428 LEU   A N   1 
ATOM   2014 C CA  . LEU   A 1 310 ? -1.25736  80.81280 5.51424   1.000 29.25299 ? 428 LEU   A CA  1 
ATOM   2015 C C   . LEU   A 1 310 ? -0.08425  81.11291 6.44184   1.000 34.14997 ? 428 LEU   A C   1 
ATOM   2016 O O   . LEU   A 1 310 ? 0.03937   80.48108 7.50118   1.000 29.95908 ? 428 LEU   A O   1 
ATOM   2017 C CB  . LEU   A 1 310 ? -0.85971  79.73161 4.50321   1.000 31.79499 ? 428 LEU   A CB  1 
ATOM   2018 C CG  . LEU   A 1 310 ? -2.02541  79.03546 3.80360   1.000 31.45708 ? 428 LEU   A CG  1 
ATOM   2019 C CD1 . LEU   A 1 310 ? -1.52922  78.09767 2.68999   1.000 29.30902 ? 428 LEU   A CD1 1 
ATOM   2020 C CD2 . LEU   A 1 310 ? -2.87079  78.28545 4.82709   1.000 32.00172 ? 428 LEU   A CD2 1 
ATOM   2021 N N   . PHE   A 1 311 ? 0.78780   82.05147 6.06894   1.000 31.13385 ? 429 PHE   A N   1 
ATOM   2022 C CA  . PHE   A 1 311 ? 2.00253   82.30881 6.82753   1.000 33.26066 ? 429 PHE   A CA  1 
ATOM   2023 C C   . PHE   A 1 311 ? 1.90280   83.54945 7.69762   1.000 33.71187 ? 429 PHE   A C   1 
ATOM   2024 O O   . PHE   A 1 311 ? 2.90789   83.96244 8.27975   1.000 41.82466 ? 429 PHE   A O   1 
ATOM   2025 C CB  . PHE   A 1 311 ? 3.20902   82.41856 5.88710   1.000 33.84283 ? 429 PHE   A CB  1 
ATOM   2026 C CG  . PHE   A 1 311 ? 3.66589   81.09721 5.34152   1.000 39.34034 ? 429 PHE   A CG  1 
ATOM   2027 C CD1 . PHE   A 1 311 ? 4.58382   80.32237 6.03653   1.000 42.36551 ? 429 PHE   A CD1 1 
ATOM   2028 C CD2 . PHE   A 1 311 ? 3.16464   80.61711 4.14123   1.000 35.62474 ? 429 PHE   A CD2 1 
ATOM   2029 C CE1 . PHE   A 1 311 ? 4.99704   79.08822 5.54181   1.000 43.88218 ? 429 PHE   A CE1 1 
ATOM   2030 C CE2 . PHE   A 1 311 ? 3.56940   79.37704 3.64172   1.000 35.59562 ? 429 PHE   A CE2 1 
ATOM   2031 C CZ  . PHE   A 1 311 ? 4.48804   78.61807 4.33771   1.000 42.20183 ? 429 PHE   A CZ  1 
ATOM   2032 N N   . GLY   A 1 312 ? 0.72531   84.15286 7.80734   1.000 35.51171 ? 430 GLY   A N   1 
ATOM   2033 C CA  . GLY   A 1 312 ? 0.55675   85.25195 8.74032   1.000 40.62005 ? 430 GLY   A CA  1 
ATOM   2034 C C   . GLY   A 1 312 ? 1.18563   86.56100 8.29425   1.000 47.41843 ? 430 GLY   A C   1 
ATOM   2035 O O   . GLY   A 1 312 ? 1.92324   87.19486 9.05592   1.000 56.44695 ? 430 GLY   A O   1 
ATOM   2036 N N   . ILE   A 1 313 ? 0.90788   86.96348 7.05541   1.000 38.41957 ? 431 ILE   A N   1 
ATOM   2037 C CA  . ILE   A 1 313 ? 1.25177   88.27906 6.51974   1.000 41.90591 ? 431 ILE   A CA  1 
ATOM   2038 C C   . ILE   A 1 313 ? -0.05927  89.04789 6.33645   1.000 45.76417 ? 431 ILE   A C   1 
ATOM   2039 O O   . ILE   A 1 313 ? -0.95813  88.59746 5.60953   1.000 44.40705 ? 431 ILE   A O   1 
ATOM   2040 C CB  . ILE   A 1 313 ? 2.03152   88.14815 5.19966   1.000 42.55059 ? 431 ILE   A CB  1 
ATOM   2041 C CG1 . ILE   A 1 313 ? 3.31764   87.34626 5.43236   1.000 36.32523 ? 431 ILE   A CG1 1 
ATOM   2042 C CG2 . ILE   A 1 313 ? 2.34588   89.52149 4.57805   1.000 42.69588 ? 431 ILE   A CG2 1 
ATOM   2043 C CD1 . ILE   A 1 313 ? 4.03367   86.94059 4.15792   1.000 41.50210 ? 431 ILE   A CD1 1 
ATOM   2044 N N   . THR   A 1 314 ? -0.17866  90.20342 7.00082   1.000 47.43046 ? 432 THR   A N   1 
ATOM   2045 C CA  . THR   A 1 314 ? -1.47164  90.88775 7.10028   1.000 49.55354 ? 432 THR   A CA  1 
ATOM   2046 C C   . THR   A 1 314 ? -1.81618  91.72356 5.86471   1.000 50.16429 ? 432 THR   A C   1 
ATOM   2047 O O   . THR   A 1 314 ? -3.00103  91.97110 5.59782   1.000 41.50452 ? 432 THR   A O   1 
ATOM   2048 C CB  . THR   A 1 314 ? -1.49248  91.78843 8.34335   1.000 51.94082 ? 432 THR   A CB  1 
ATOM   2049 O OG1 . THR   A 1 314 ? -0.65190  92.92951 8.12980   1.000 50.27860 ? 432 THR   A OG1 1 
ATOM   2050 C CG2 . THR   A 1 314 ? -0.98409  91.02439 9.56409   1.000 55.96492 ? 432 THR   A CG2 1 
ATOM   2051 N N   . GLY   A 1 315 ? -0.81388  92.18149 5.11590   1.000 53.19993 ? 433 GLY   A N   1 
ATOM   2052 C CA  . GLY   A 1 315 ? -1.02188  93.15154 4.05873   1.000 42.76325 ? 433 GLY   A CA  1 
ATOM   2053 C C   . GLY   A 1 315 ? -0.89121  94.60404 4.48575   1.000 48.82752 ? 433 GLY   A C   1 
ATOM   2054 O O   . GLY   A 1 315 ? -1.04475  95.49519 3.63989   1.000 46.89300 ? 433 GLY   A O   1 
ATOM   2055 N N   . SER   A 1 316 ? -0.61512  94.87064 5.76311   1.000 52.54655 ? 434 SER   A N   1 
ATOM   2056 C CA  . SER   A 1 316 ? -0.54886  96.23560 6.29022   1.000 54.50671 ? 434 SER   A CA  1 
ATOM   2057 C C   . SER   A 1 316 ? 0.86840   96.59166 6.74020   1.000 58.99018 ? 434 SER   A C   1 
ATOM   2058 O O   . SER   A 1 316 ? 1.65660   95.71451 7.09289   1.000 61.63021 ? 434 SER   A O   1 
ATOM   2059 C CB  . SER   A 1 316 ? -1.53673  96.40261 7.45870   1.000 47.62308 ? 434 SER   A CB  1 
ATOM   2060 O OG  . SER   A 1 316 ? -1.51382  97.71926 8.00076   1.000 55.30802 ? 434 SER   A OG  1 
HETATM 2061 C C1  . A1IHA B 2 .   ? 10.48465  80.24598 0.56811   1.000 41.59351 ? 501 A1IHA A C1  1 
HETATM 2062 C C2  . A1IHA B 2 .   ? 9.69755   80.05541 -0.55730  1.000 33.83384 ? 501 A1IHA A C2  1 
HETATM 2063 C C3  . A1IHA B 2 .   ? 8.60394   79.19771 -0.56855  1.000 35.28594 ? 501 A1IHA A C3  1 
HETATM 2064 C C4  . A1IHA B 2 .   ? 7.80534   79.12296 -1.84440  1.000 33.30555 ? 501 A1IHA A C4  1 
HETATM 2065 C C5  . A1IHA B 2 .   ? 8.30142   78.49361 0.61986   1.000 44.27403 ? 501 A1IHA A C5  1 
HETATM 2066 C C6  . A1IHA B 2 .   ? 7.97657   75.34720 -0.98125  1.000 45.57851 ? 501 A1IHA A C6  1 
HETATM 2067 C C7  . A1IHA B 2 .   ? 7.74448   74.56788 -2.11974  1.000 43.90735 ? 501 A1IHA A C7  1 
HETATM 2068 N N   . A1IHA B 2 .   ? 7.01306   76.36987 -0.63338  1.000 43.19594 ? 501 A1IHA A N   1 
HETATM 2069 C C   . A1IHA B 2 .   ? 11.64325  81.21071 0.54945   1.000 46.63501 ? 501 A1IHA A C   1 
HETATM 2070 O O   . A1IHA B 2 .   ? 6.90934   76.54887 1.75797   1.000 47.65301 ? 501 A1IHA A O   1 
HETATM 2071 C C10 . A1IHA B 2 .   ? 9.92047   74.01442 -0.48201  1.000 38.94755 ? 501 A1IHA A C10 1 
HETATM 2072 C C11 . A1IHA B 2 .   ? 9.08813   75.09277 -0.17396  1.000 43.75493 ? 501 A1IHA A C11 1 
HETATM 2073 C C12 . A1IHA B 2 .   ? 11.37259  72.42305 -0.44950  1.000 42.47039 ? 501 A1IHA A C12 1 
HETATM 2074 C C13 . A1IHA B 2 .   ? 12.43594  71.47527 -0.00712  1.000 41.05922 ? 501 A1IHA A C13 1 
HETATM 2075 C C14 . A1IHA B 2 .   ? 13.68546  71.46956 -0.87563  1.000 45.97785 ? 501 A1IHA A C14 1 
HETATM 2076 C C15 . A1IHA B 2 .   ? 14.56154  72.68734 -0.64433  1.000 53.11078 ? 501 A1IHA A C15 1 
HETATM 2077 C C16 . A1IHA B 2 .   ? 14.97464  72.85513 0.80532   1.000 52.24447 ? 501 A1IHA A C16 1 
HETATM 2078 C C17 . A1IHA B 2 .   ? 15.39525  74.26847 1.18204   1.000 55.23778 ? 501 A1IHA A C17 1 
HETATM 2079 C C18 . A1IHA B 2 .   ? 16.63265  74.76881 0.46193   1.000 59.00396 ? 501 A1IHA A C18 1 
HETATM 2080 C C19 . A1IHA B 2 .   ? 17.20767  76.03892 1.06855   1.000 59.22176 ? 501 A1IHA A C19 1 
HETATM 2081 C C20 . A1IHA B 2 .   ? 15.60017  77.87757 1.35016   1.000 61.70132 ? 501 A1IHA A C20 1 
HETATM 2082 C C21 . A1IHA B 2 .   ? 15.13893  79.22510 0.84584   1.000 60.97211 ? 501 A1IHA A C21 1 
HETATM 2083 C C22 . A1IHA B 2 .   ? 15.49260  80.91766 -0.78220  1.000 65.64730 ? 501 A1IHA A C22 1 
HETATM 2084 C C23 . A1IHA B 2 .   ? 16.58253  81.41716 -1.67885  1.000 64.36591 ? 501 A1IHA A C23 1 
HETATM 2085 C C24 . A1IHA B 2 .   ? 17.79271  80.53707 -3.52574  1.000 66.88458 ? 501 A1IHA A C24 1 
HETATM 2086 C C25 . A1IHA B 2 .   ? 17.61770  79.97427 -4.91024  1.000 60.96198 ? 501 A1IHA A C25 1 
HETATM 2087 C C26 . A1IHA B 2 .   ? 15.61065  78.71837 -5.51860  1.000 58.88917 ? 501 A1IHA A C26 1 
HETATM 2088 C C27 . A1IHA B 2 .   ? 14.88065  77.39490 -5.39625  1.000 56.76274 ? 501 A1IHA A C27 1 
HETATM 2089 C C28 . A1IHA B 2 .   ? 13.89889  77.27744 -4.22911  1.000 50.89695 ? 501 A1IHA A C28 1 
HETATM 2090 C C29 . A1IHA B 2 .   ? 14.65167  77.18807 -2.88739  1.000 51.41478 ? 501 A1IHA A C29 1 
HETATM 2091 C C30 . A1IHA B 2 .   ? 13.67593  77.05883 -1.71070  1.000 52.77802 ? 501 A1IHA A C30 1 
HETATM 2092 C C31 . A1IHA B 2 .   ? 12.75645  78.28120 -1.67706  1.000 51.27534 ? 501 A1IHA A C31 1 
HETATM 2093 C C32 . A1IHA B 2 .   ? 11.97113  78.36750 -2.98621  1.000 48.60498 ? 501 A1IHA A C32 1 
HETATM 2094 C C33 . A1IHA B 2 .   ? 11.13116  77.10213 -3.16100  1.000 43.00455 ? 501 A1IHA A C33 1 
HETATM 2095 C C34 . A1IHA B 2 .   ? 12.05012  75.87915 -3.19482  1.000 47.95232 ? 501 A1IHA A C34 1 
HETATM 2096 C C35 . A1IHA B 2 .   ? 12.83734  75.79442 -1.88585  1.000 50.84469 ? 501 A1IHA A C35 1 
HETATM 2097 C C36 . A1IHA B 2 .   ? 13.02981  76.01174 -4.36841  1.000 49.66933 ? 501 A1IHA A C36 1 
HETATM 2098 C C37 . A1IHA B 2 .   ? 12.95184  78.49357 -4.15953  1.000 50.14446 ? 501 A1IHA A C37 1 
HETATM 2099 C C38 . A1IHA B 2 .   ? 10.61059  71.01910 -2.44621  1.000 35.59669 ? 501 A1IHA A C38 1 
HETATM 2100 C C39 . A1IHA B 2 .   ? 10.64085  71.37048 -3.91531  1.000 35.14040 ? 501 A1IHA A C39 1 
HETATM 2101 C C40 . A1IHA B 2 .   ? 9.68044   70.86919 -4.78393  1.000 33.57881 ? 501 A1IHA A C40 1 
HETATM 2102 C C41 . A1IHA B 2 .   ? 9.64140   71.27571 -6.11066  1.000 34.08889 ? 501 A1IHA A C41 1 
HETATM 2103 C C42 . A1IHA B 2 .   ? 10.57291  72.17552 -6.58805  1.000 30.50495 ? 501 A1IHA A C42 1 
HETATM 2104 C C43 . A1IHA B 2 .   ? 11.55022  72.65911 -5.74200  1.000 37.48856 ? 501 A1IHA A C43 1 
HETATM 2105 C C44 . A1IHA B 2 .   ? 11.58508  72.25942 -4.41471  1.000 39.29508 ? 501 A1IHA A C44 1 
HETATM 2106 C C45 . A1IHA B 2 .   ? 9.08179   78.67385 1.78746   1.000 41.63908 ? 501 A1IHA A C45 1 
HETATM 2107 C C46 . A1IHA B 2 .   ? 8.80708   78.05576 3.13414   1.000 39.12496 ? 501 A1IHA A C46 1 
HETATM 2108 C C47 . A1IHA B 2 .   ? 10.16337  79.54405 1.71883   1.000 37.60225 ? 501 A1IHA A C47 1 
HETATM 2109 C C8  . A1IHA B 2 .   ? 8.56575   73.49165 -2.42474  1.000 39.88877 ? 501 A1IHA A C8  1 
HETATM 2110 C C9  . A1IHA B 2 .   ? 9.63605   73.21741 -1.57879  1.000 40.67611 ? 501 A1IHA A C9  1 
HETATM 2111 N N1  . A1IHA B 2 .   ? 11.03101  73.51120 0.20034   1.000 38.19383 ? 501 A1IHA A N1  1 
HETATM 2112 N N2  . A1IHA B 2 .   ? 16.52287  77.24608 0.62331   1.000 55.41967 ? 501 A1IHA A N2  1 
HETATM 2113 N N3  . A1IHA B 2 .   ? 16.79956  78.76898 -4.92103  1.000 59.02660 ? 501 A1IHA A N3  1 
HETATM 2114 N N4  . A1IHA B 2 .   ? 10.57353  72.17716 -1.54660  1.000 36.33575 ? 501 A1IHA A N4  1 
HETATM 2115 O O1  . A1IHA B 2 .   ? 5.70744   78.23138 0.40762   1.000 34.75840 ? 501 A1IHA A O1  1 
HETATM 2116 O O2  . A1IHA B 2 .   ? 15.12829  77.42675 2.39101   1.000 57.27419 ? 501 A1IHA A O2  1 
HETATM 2117 O O3  . A1IHA B 2 .   ? 15.73154  79.57058 -0.39360  1.000 61.84927 ? 501 A1IHA A O3  1 
HETATM 2118 O O4  . A1IHA B 2 .   ? 16.51790  80.76264 -2.93883  1.000 62.87889 ? 501 A1IHA A O4  1 
HETATM 2119 O O5  . A1IHA B 2 .   ? 15.12658  79.66924 -6.12769  1.000 55.38103 ? 501 A1IHA A O5  1 
HETATM 2120 S S   . A1IHA B 2 .   ? 6.86836   77.42150 0.62319   1.000 46.65429 ? 501 A1IHA A S   1 
HETATM 2121 C C1  . GOL   C 3 .   ? 0.41037   48.97617 -1.88888  1.000 57.28402 ? 502 GOL   A C1  1 
HETATM 2122 O O1  . GOL   C 3 .   ? 0.64543   47.74116 -1.24135  1.000 55.29652 ? 502 GOL   A O1  1 
HETATM 2123 C C2  . GOL   C 3 .   ? -0.04014  50.03010 -0.80520  1.000 45.42151 ? 502 GOL   A C2  1 
HETATM 2124 O O2  . GOL   C 3 .   ? -1.26842  49.68647 -0.24954  1.000 51.98222 ? 502 GOL   A O2  1 
HETATM 2125 C C3  . GOL   C 3 .   ? -0.09128  51.43241 -1.55974  1.000 43.72155 ? 502 GOL   A C3  1 
HETATM 2126 O O3  . GOL   C 3 .   ? 1.21288   52.03733 -1.53614  1.000 31.92987 ? 502 GOL   A O3  1 
HETATM 2127 C C1  . GOL   D 3 .   ? 7.74048   57.90827 -6.83205  1.000 51.71928 ? 503 GOL   A C1  1 
HETATM 2128 O O1  . GOL   D 3 .   ? 8.14613   56.83798 -6.00803  1.000 56.35118 ? 503 GOL   A O1  1 
HETATM 2129 C C2  . GOL   D 3 .   ? 8.91839   58.30260 -7.76359  1.000 51.67686 ? 503 GOL   A C2  1 
HETATM 2130 O O2  . GOL   D 3 .   ? 10.15248  57.89217 -7.24096  1.000 58.87579 ? 503 GOL   A O2  1 
HETATM 2131 C C3  . GOL   D 3 .   ? 8.79727   59.84241 -7.84950  1.000 43.07280 ? 503 GOL   A C3  1 
HETATM 2132 O O3  . GOL   D 3 .   ? 9.50808   60.29475 -8.97074  1.000 43.43111 ? 503 GOL   A O3  1 
HETATM 2133 C C1  . IPA   E 4 .   ? 10.37334  83.81252 -19.50394 1.000 51.13304 ? 504 IPA   A C1  1 
HETATM 2134 C C2  . IPA   E 4 .   ? 9.07952   84.61108 -19.44460 1.000 52.25116 ? 504 IPA   A C2  1 
HETATM 2135 C C3  . IPA   E 4 .   ? 7.88057   83.67385 -19.32208 1.000 46.87156 ? 504 IPA   A C3  1 
HETATM 2136 O O2  . IPA   E 4 .   ? 9.11199   85.50496 -18.35453 1.000 60.01092 ? 504 IPA   A O2  1 
HETATM 2137 C C1  . IPA   F 4 .   ? -6.38975  79.68051 6.03106   1.000 47.44232 ? 505 IPA   A C1  1 
HETATM 2138 C C2  . IPA   F 4 .   ? -6.98823  79.01101 4.80497   1.000 50.16324 ? 505 IPA   A C2  1 
HETATM 2139 C C3  . IPA   F 4 .   ? -8.09981  78.07164 5.25024   1.000 50.89379 ? 505 IPA   A C3  1 
HETATM 2140 O O2  . IPA   F 4 .   ? -7.55386  80.00892 3.98686   1.000 59.50220 ? 505 IPA   A O2  1 
HETATM 2141 O O   . HOH   G 5 .   ? -3.63018  64.70251 -11.67337 1.000 33.45654 ? 601 HOH   A O   1 
HETATM 2142 O O   . HOH   G 5 .   ? -7.52715  59.49578 21.64314  1.000 48.06790 ? 602 HOH   A O   1 
HETATM 2143 O O   . HOH   G 5 .   ? -15.15302 62.43095 4.24761   1.000 49.68092 ? 603 HOH   A O   1 
HETATM 2144 O O   . HOH   G 5 .   ? -8.32193  78.48395 16.42180  1.000 47.33258 ? 604 HOH   A O   1 
HETATM 2145 O O   . HOH   G 5 .   ? -15.82642 63.96759 13.79881  1.000 52.44015 ? 605 HOH   A O   1 
HETATM 2146 O O   . HOH   G 5 .   ? 9.35013   87.13236 -16.83939 1.000 58.98598 ? 606 HOH   A O   1 
HETATM 2147 O O   . HOH   G 5 .   ? 4.18902   48.37565 16.79575  1.000 37.65941 ? 607 HOH   A O   1 
HETATM 2148 O O   . HOH   G 5 .   ? -1.57387  94.85374 1.48321   1.000 33.65420 ? 608 HOH   A O   1 
HETATM 2149 O O   . HOH   G 5 .   ? 16.05648  71.48343 11.56994  1.000 57.85016 ? 609 HOH   A O   1 
HETATM 2150 O O   . HOH   G 5 .   ? 1.256     54.542   -5.455    1.000 35.60235 ? 610 HOH   A O   1 
HETATM 2151 O O   . HOH   G 5 .   ? 16.41731  72.79709 5.10151   1.000 48.49000 ? 611 HOH   A O   1 
HETATM 2152 O O   . HOH   G 5 .   ? -14.965   43.569   7.868     1.000 60.06938 ? 612 HOH   A O   1 
HETATM 2153 O O   . HOH   G 5 .   ? -19.26295 68.89510 10.75865  1.000 52.80938 ? 613 HOH   A O   1 
HETATM 2154 O O   . HOH   G 5 .   ? 12.18060  50.41796 8.02496   1.000 49.00097 ? 614 HOH   A O   1 
HETATM 2155 O O   . HOH   G 5 .   ? 15.35103  81.99440 -7.00744  1.000 38.20946 ? 615 HOH   A O   1 
HETATM 2156 O O   . HOH   G 5 .   ? 9.09837   47.54358 15.51789  1.000 39.82169 ? 616 HOH   A O   1 
HETATM 2157 O O   . HOH   G 5 .   ? 11.75180  85.89812 10.13228  1.000 46.67502 ? 617 HOH   A O   1 
HETATM 2158 O O   . HOH   G 5 .   ? 8.28510   88.73898 -6.10924  1.000 50.42436 ? 618 HOH   A O   1 
HETATM 2159 O O   . HOH   G 5 .   ? 12.12211  87.55774 -8.29861  1.000 54.77544 ? 619 HOH   A O   1 
HETATM 2160 O O   . HOH   G 5 .   ? -9.13024  51.08716 4.83293   1.000 41.42327 ? 620 HOH   A O   1 
HETATM 2161 O O   . HOH   G 5 .   ? 14.13134  62.14517 -12.69223 1.000 44.20725 ? 621 HOH   A O   1 
HETATM 2162 O O   . HOH   G 5 .   ? 15.37021  56.76388 6.30852   1.000 34.49924 ? 622 HOH   A O   1 
HETATM 2163 O O   . HOH   G 5 .   ? -8.05010  71.87063 -4.70528  1.000 41.00995 ? 623 HOH   A O   1 
HETATM 2164 O O   . HOH   G 5 .   ? 3.68906   63.36832 -11.83496 1.000 38.44096 ? 624 HOH   A O   1 
HETATM 2165 O O   . HOH   G 5 .   ? -0.20581  68.50057 -7.50553  1.000 32.02011 ? 625 HOH   A O   1 
HETATM 2166 O O   . HOH   G 5 .   ? -1.76393  50.44064 17.53362  1.000 44.08966 ? 626 HOH   A O   1 
HETATM 2167 O O   . HOH   G 5 .   ? -2.01801  48.21972 2.16140   1.000 52.97663 ? 627 HOH   A O   1 
HETATM 2168 O O   . HOH   G 5 .   ? -3.01952  85.06483 8.14900   1.000 44.91984 ? 628 HOH   A O   1 
HETATM 2169 O O   . HOH   G 5 .   ? -5.68687  62.04451 -7.61605  1.000 31.68853 ? 629 HOH   A O   1 
HETATM 2170 O O   . HOH   G 5 .   ? 8.79827   44.62042 11.37545  1.000 43.85467 ? 630 HOH   A O   1 
HETATM 2171 O O   . HOH   G 5 .   ? -11.63027 65.45882 -7.07744  1.000 42.67451 ? 631 HOH   A O   1 
HETATM 2172 O O   . HOH   G 5 .   ? 13.46705  42.94592 6.66341   1.000 55.71729 ? 632 HOH   A O   1 
HETATM 2173 O O   . HOH   G 5 .   ? 7.40579   47.48133 13.04465  1.000 40.11679 ? 633 HOH   A O   1 
HETATM 2174 O O   . HOH   G 5 .   ? -0.61052  58.89717 -0.29379  1.000 24.75687 ? 634 HOH   A O   1 
HETATM 2175 O O   . HOH   G 5 .   ? 4.59328   67.09562 11.72229  1.000 31.94455 ? 635 HOH   A O   1 
HETATM 2176 O O   . HOH   G 5 .   ? -13.74439 66.12413 14.72872  1.000 46.08160 ? 636 HOH   A O   1 
HETATM 2177 O O   . HOH   G 5 .   ? 0.63917   80.84365 10.05775  1.000 45.17476 ? 637 HOH   A O   1 
HETATM 2178 O O   . HOH   G 5 .   ? 1.98648   91.30679 8.06248   1.000 48.64054 ? 638 HOH   A O   1 
HETATM 2179 O O   . HOH   G 5 .   ? 5.87044   62.93054 16.13418  1.000 34.16099 ? 639 HOH   A O   1 
HETATM 2180 O O   . HOH   G 5 .   ? -3.635    61.347   -9.750    1.000 47.26610 ? 640 HOH   A O   1 
HETATM 2181 O O   . HOH   G 5 .   ? -0.65464  79.01992 -8.45022  1.000 34.77424 ? 641 HOH   A O   1 
HETATM 2182 O O   . HOH   G 5 .   ? 9.97338   82.83161 -11.51893 1.000 29.46393 ? 642 HOH   A O   1 
HETATM 2183 O O   . HOH   G 5 .   ? -10.61338 51.22971 16.75176  1.000 51.04031 ? 643 HOH   A O   1 
HETATM 2184 O O   . HOH   G 5 .   ? 8.00663   49.25692 1.66837   1.000 39.39975 ? 644 HOH   A O   1 
HETATM 2185 O O   . HOH   G 5 .   ? -1.96539  71.65569 12.23821  1.000 32.05767 ? 645 HOH   A O   1 
HETATM 2186 O O   . HOH   G 5 .   ? 7.34529   58.11878 -2.28497  1.000 27.71599 ? 646 HOH   A O   1 
HETATM 2187 O O   . HOH   G 5 .   ? 7.27946   54.89925 -1.26441  1.000 34.39663 ? 647 HOH   A O   1 
HETATM 2188 O O   . HOH   G 5 .   ? -11.62033 56.50514 -2.09900  1.000 31.51917 ? 648 HOH   A O   1 
HETATM 2189 O O   . HOH   G 5 .   ? 18.89468  75.31952 -19.68001 1.000 43.37263 ? 649 HOH   A O   1 
HETATM 2190 O O   . HOH   G 5 .   ? 20.21453  62.18229 -5.75383  1.000 39.15144 ? 650 HOH   A O   1 
HETATM 2191 O O   . HOH   G 5 .   ? 8.91236   56.57439 1.41239   1.000 23.52927 ? 651 HOH   A O   1 
HETATM 2192 O O   . HOH   G 5 .   ? -7.568    87.663   3.811     1.000 30.56965 ? 652 HOH   A O   1 
HETATM 2193 O O   . HOH   G 5 .   ? -15.37352 58.35866 -3.05818  1.000 43.51963 ? 653 HOH   A O   1 
HETATM 2194 O O   . HOH   G 5 .   ? 16.522    84.377   -14.637   1.000 47.17195 ? 654 HOH   A O   1 
HETATM 2195 O O   . HOH   G 5 .   ? -1.21441  69.56986 -2.82434  1.000 23.88392 ? 655 HOH   A O   1 
HETATM 2196 O O   . HOH   G 5 .   ? 18.35678  78.04900 -1.55938  1.000 59.66442 ? 656 HOH   A O   1 
HETATM 2197 O O   . HOH   G 5 .   ? 3.43399   86.78284 -5.86752  1.000 36.37113 ? 657 HOH   A O   1 
HETATM 2198 O O   . HOH   G 5 .   ? 10.61591  51.03298 6.01561   1.000 42.60346 ? 658 HOH   A O   1 
HETATM 2199 O O   . HOH   G 5 .   ? -2.720    97.114   10.431    1.000 42.69294 ? 659 HOH   A O   1 
HETATM 2200 O O   . HOH   G 5 .   ? -1.71818  78.04109 13.65464  1.000 36.22357 ? 660 HOH   A O   1 
HETATM 2201 O O   . HOH   G 5 .   ? -10.74840 55.00490 0.05871   1.000 37.36386 ? 661 HOH   A O   1 
HETATM 2202 O O   . HOH   G 5 .   ? 9.51335   58.44707 17.66100  1.000 30.29356 ? 662 HOH   A O   1 
HETATM 2203 O O   . HOH   G 5 .   ? -14.11540 49.58066 14.86381  1.000 47.98772 ? 663 HOH   A O   1 
HETATM 2204 O O   . HOH   G 5 .   ? 1.76025   68.29043 -15.95232 1.000 30.28884 ? 664 HOH   A O   1 
HETATM 2205 O O   . HOH   G 5 .   ? 8.58822   80.18660 12.71248  1.000 41.82202 ? 665 HOH   A O   1 
HETATM 2206 O O   . HOH   G 5 .   ? 9.90486   55.69227 -1.36957  1.000 31.86493 ? 666 HOH   A O   1 
HETATM 2207 O O   . HOH   G 5 .   ? 16.53372  66.44387 8.34351   1.000 38.16547 ? 667 HOH   A O   1 
HETATM 2208 O O   . HOH   G 5 .   ? 5.99111   47.70902 0.56847   1.000 50.60574 ? 668 HOH   A O   1 
HETATM 2209 O O   . HOH   G 5 .   ? -12.45453 69.76584 -0.44900  1.000 37.08470 ? 669 HOH   A O   1 
HETATM 2210 O O   . HOH   G 5 .   ? 14.69438  90.23985 6.22171   1.000 44.82317 ? 670 HOH   A O   1 
HETATM 2211 O O   . HOH   G 5 .   ? 9.01286   85.25910 -12.84637 1.000 32.72503 ? 671 HOH   A O   1 
HETATM 2212 O O   . HOH   G 5 .   ? 14.47321  93.09347 -3.18115  1.000 56.72183 ? 672 HOH   A O   1 
HETATM 2213 O O   . HOH   G 5 .   ? 16.04812  65.22849 -13.62797 1.000 40.64709 ? 673 HOH   A O   1 
HETATM 2214 O O   . HOH   G 5 .   ? -5.78684  47.23849 15.39012  1.000 52.76760 ? 674 HOH   A O   1 
HETATM 2215 O O   . HOH   G 5 .   ? 7.74465   64.08748 -14.08133 1.000 46.84336 ? 675 HOH   A O   1 
HETATM 2216 O O   . HOH   G 5 .   ? 6.27116   74.26652 13.58124  1.000 37.79481 ? 676 HOH   A O   1 
HETATM 2217 O O   . HOH   G 5 .   ? 5.91522   73.97035 1.22250   1.000 37.01226 ? 677 HOH   A O   1 
HETATM 2218 O O   . HOH   G 5 .   ? 15.20366  42.02003 13.19787  1.000 40.78920 ? 678 HOH   A O   1 
HETATM 2219 O O   . HOH   G 5 .   ? 16.55705  58.18493 -0.47553  1.000 33.43174 ? 679 HOH   A O   1 
HETATM 2220 O O   . HOH   G 5 .   ? 20.18502  66.15823 -8.84792  1.000 46.15906 ? 680 HOH   A O   1 
HETATM 2221 O O   . HOH   G 5 .   ? 6.18162   64.50447 -18.74554 1.000 44.74762 ? 681 HOH   A O   1 
HETATM 2222 O O   . HOH   G 5 .   ? 4.82594   91.44879 3.09711   1.000 47.38868 ? 682 HOH   A O   1 
HETATM 2223 O O   . HOH   G 5 .   ? 13.38318  57.56099 -5.58506  1.000 33.78489 ? 683 HOH   A O   1 
HETATM 2224 O O   . HOH   G 5 .   ? -0.37718  81.53646 -7.67075  1.000 30.36492 ? 684 HOH   A O   1 
HETATM 2225 O O   . HOH   G 5 .   ? 12.10170  64.24308 -15.40414 1.000 59.17595 ? 685 HOH   A O   1 
HETATM 2226 O O   . HOH   G 5 .   ? 13.19099  63.82483 15.40211  1.000 43.59011 ? 686 HOH   A O   1 
HETATM 2227 O O   . HOH   G 5 .   ? 5.187     59.509   -7.848    1.000 46.62931 ? 687 HOH   A O   1 
HETATM 2228 O O   . HOH   G 5 .   ? -14.66974 73.51953 6.06928   1.000 47.52514 ? 688 HOH   A O   1 
HETATM 2229 O O   . HOH   G 5 .   ? -4.66230  72.92891 -6.50102  1.000 38.66285 ? 689 HOH   A O   1 
HETATM 2230 O O   . HOH   G 5 .   ? -16.40421 68.17774 2.69084   1.000 54.93952 ? 690 HOH   A O   1 
HETATM 2231 O O   . HOH   G 5 .   ? 10.54060  41.81563 11.91569  1.000 57.20380 ? 691 HOH   A O   1 
HETATM 2232 O O   . HOH   G 5 .   ? 3.86340   74.46989 14.49603  1.000 45.00451 ? 692 HOH   A O   1 
HETATM 2233 O O   . HOH   G 5 .   ? 3.98286   49.34226 14.41146  1.000 32.01265 ? 693 HOH   A O   1 
HETATM 2234 O O   . HOH   G 5 .   ? -8.35969  81.04726 13.53808  1.000 44.26845 ? 694 HOH   A O   1 
HETATM 2235 O O   . HOH   G 5 .   ? 11.61780  86.28273 -12.07149 1.000 47.89772 ? 695 HOH   A O   1 
HETATM 2236 O O   . HOH   G 5 .   ? -5.26720  48.86510 17.47790  1.000 54.68510 ? 696 HOH   A O   1 
HETATM 2237 O O   . HOH   G 5 .   ? -8.47913  74.95515 -1.89324  1.000 32.39630 ? 697 HOH   A O   1 
HETATM 2238 O O   . HOH   G 5 .   ? -7.02904  54.19479 16.03633  1.000 35.20626 ? 698 HOH   A O   1 
HETATM 2239 O O   . HOH   G 5 .   ? 6.66628   49.91209 13.86044  1.000 31.85580 ? 699 HOH   A O   1 
HETATM 2240 O O   . HOH   G 5 .   ? 3.82740   78.44358 9.13993   1.000 42.96099 ? 700 HOH   A O   1 
HETATM 2241 O O   . HOH   G 5 .   ? -5.004    90.506   7.132     1.000 42.91177 ? 701 HOH   A O   1 
HETATM 2242 O O   . HOH   G 5 .   ? 12.88165  75.19629 14.56938  1.000 44.17724 ? 702 HOH   A O   1 
HETATM 2243 O O   . HOH   G 5 .   ? 7.631     73.015   -22.989   1.000 43.69171 ? 703 HOH   A O   1 
HETATM 2244 O O   . HOH   G 5 .   ? 6.52471   84.76660 -16.17744 1.000 41.44082 ? 704 HOH   A O   1 
HETATM 2245 O O   . HOH   G 5 .   ? 3.54685   97.78462 6.09249   1.000 61.29079 ? 705 HOH   A O   1 
HETATM 2246 O O   . HOH   G 5 .   ? -8.774    86.682   7.192     1.000 56.06937 ? 706 HOH   A O   1 
HETATM 2247 O O   . HOH   G 5 .   ? -9.35965  62.88148 -8.48689  1.000 47.05960 ? 707 HOH   A O   1 
HETATM 2248 O O   . HOH   G 5 .   ? 3.80938   67.02027 14.62126  1.000 47.38357 ? 708 HOH   A O   1 
HETATM 2249 O O   . HOH   G 5 .   ? 1.94564   92.73862 6.15394   1.000 50.91904 ? 709 HOH   A O   1 
HETATM 2250 O O   . HOH   G 5 .   ? 1.46656   92.05240 2.19926   1.000 52.11476 ? 710 HOH   A O   1 
HETATM 2251 O O   . HOH   G 5 .   ? 1.17926   71.22771 -16.07907 1.000 47.83783 ? 711 HOH   A O   1 
HETATM 2252 O O   . HOH   G 5 .   ? 13.64862  66.83098 15.71894  1.000 52.73857 ? 712 HOH   A O   1 
HETATM 2253 O O   . HOH   G 5 .   ? 0.196     84.511   -9.770    1.000 45.83722 ? 713 HOH   A O   1 
HETATM 2254 O O   . HOH   G 5 .   ? 2.40213   79.23895 -17.62137 1.000 44.46881 ? 714 HOH   A O   1 
HETATM 2255 O O   . HOH   G 5 .   ? -1.63139  62.89586 20.31133  1.000 43.41691 ? 715 HOH   A O   1 
HETATM 2256 O O   . HOH   G 5 .   ? -3.51672  70.83347 -5.77089  1.000 41.67795 ? 716 HOH   A O   1 
HETATM 2257 O O   . HOH   G 5 .   ? -3.16860  78.00626 -7.90166  1.000 38.07943 ? 717 HOH   A O   1 
HETATM 2258 O O   . HOH   G 5 .   ? -3.23271  76.62362 -11.88522 1.000 43.57675 ? 718 HOH   A O   1 
HETATM 2259 O O   . HOH   G 5 .   ? 14.90283  69.71913 -14.07389 1.000 42.42175 ? 719 HOH   A O   1 
HETATM 2260 O O   . HOH   G 5 .   ? 2.86943   75.85392 7.58527   1.000 32.62565 ? 720 HOH   A O   1 
HETATM 2261 O O   . HOH   G 5 .   ? 12.90798  51.21044 4.76946   1.000 54.44783 ? 721 HOH   A O   1 
HETATM 2262 O O   . HOH   G 5 .   ? -4.52350  78.71326 -13.46558 1.000 54.21732 ? 722 HOH   A O   1 
HETATM 2263 O O   . HOH   G 5 .   ? 3.70694   55.20056 -1.98125  1.000 38.07471 ? 723 HOH   A O   1 
HETATM 2264 O O   . HOH   G 5 .   ? -5.107    81.378   -4.112    1.000 47.08871 ? 724 HOH   A O   1 
HETATM 2265 O O   . HOH   G 5 .   ? -5.53442  81.39570 13.08898  1.000 48.22077 ? 725 HOH   A O   1 
HETATM 2266 O O   . HOH   G 5 .   ? -11.34127 70.27283 22.99958  1.000 49.78172 ? 726 HOH   A O   1 
HETATM 2267 O O   . HOH   G 5 .   ? -17.54096 77.01983 13.45195  1.000 50.24728 ? 727 HOH   A O   1 
HETATM 2268 O O   . HOH   G 5 .   ? 0.19768   76.92417 -18.56529 1.000 48.68357 ? 728 HOH   A O   1 
HETATM 2269 O O   . HOH   G 5 .   ? -0.11291  79.35736 -11.17293 1.000 38.61976 ? 729 HOH   A O   1 
HETATM 2270 O O   . HOH   G 5 .   ? 6.30960   50.82719 -0.91325  1.000 47.25139 ? 730 HOH   A O   1 
HETATM 2271 O O   . HOH   G 5 .   ? -0.98333  57.82171 25.05309  1.000 61.49509 ? 731 HOH   A O   1 
HETATM 2272 O O   . HOH   G 5 .   ? 7.88249   51.25442 15.92736  1.000 28.33962 ? 732 HOH   A O   1 
HETATM 2273 O O   . HOH   G 5 .   ? 14.40361  64.79705 -17.83493 1.000 60.44380 ? 733 HOH   A O   1 
HETATM 2274 O O   . HOH   G 5 .   ? 15.06947  57.04643 -12.27400 1.000 44.75598 ? 734 HOH   A O   1 
HETATM 2275 O O   . HOH   G 5 .   ? 5.72461   45.81416 12.62414  1.000 45.71983 ? 735 HOH   A O   1 
HETATM 2276 O O   . HOH   G 5 .   ? -16.57454 64.88798 2.02542   1.000 52.55022 ? 736 HOH   A O   1 
HETATM 2277 O O   . HOH   G 5 .   ? 0.615     83.567   -11.760   1.000 48.56801 ? 737 HOH   A O   1 
HETATM 2278 O O   . HOH   G 5 .   ? -7.16604  69.86233 -5.39492  1.000 41.78380 ? 738 HOH   A O   1 
HETATM 2279 O O   . HOH   G 5 .   ? 13.67283  59.13177 11.99902  1.000 50.82490 ? 739 HOH   A O   1 
HETATM 2280 O O   . HOH   G 5 .   ? 4.44664   57.61564 -4.94022  1.000 40.77523 ? 740 HOH   A O   1 
HETATM 2281 O O   . HOH   G 5 .   ? -11.36070 75.71888 6.24476   1.000 42.50941 ? 741 HOH   A O   1 
HETATM 2282 O O   . HOH   G 5 .   ? -3.77716  87.61724 6.91297   1.000 47.52651 ? 742 HOH   A O   1 
HETATM 2283 O O   . HOH   G 5 .   ? -1.11823  40.28474 10.18158  1.000 58.37556 ? 743 HOH   A O   1 
HETATM 2284 O O   . HOH   G 5 .   ? -11.61422 63.39367 19.15067  1.000 50.55911 ? 744 HOH   A O   1 
HETATM 2285 O O   . HOH   G 5 .   ? -7.24549  66.89527 -7.85154  1.000 44.03372 ? 745 HOH   A O   1 
HETATM 2286 O O   . HOH   G 5 .   ? -3.039    51.976   -2.483    1.000 45.84889 ? 746 HOH   A O   1 
HETATM 2287 O O   . HOH   G 5 .   ? -4.98083  78.40106 -19.79971 1.000 55.06836 ? 747 HOH   A O   1 
HETATM 2288 O O   . HOH   G 5 .   ? -5.05710  70.33438 -7.10532  1.000 46.99378 ? 748 HOH   A O   1 
HETATM 2289 O O   . HOH   G 5 .   ? 6.04719   76.50518 12.03801  1.000 46.28322 ? 749 HOH   A O   1 
HETATM 2290 O O   . HOH   G 5 .   ? -12.41680 72.20796 -1.35339  1.000 49.98283 ? 750 HOH   A O   1 
HETATM 2291 O O   . HOH   G 5 .   ? -2.15271  68.87723 -5.66446  1.000 33.59478 ? 751 HOH   A O   1 
HETATM 2292 O O   . HOH   G 5 .   ? -6.21125  65.19459 -13.85904 1.000 61.22373 ? 752 HOH   A O   1 
HETATM 2293 O O   . HOH   G 5 .   ? 14.00664  55.53480 -3.66056  1.000 49.52176 ? 753 HOH   A O   1 
HETATM 2294 O O   . HOH   G 5 .   ? -9.34963  69.13125 -5.50686  1.000 38.40156 ? 754 HOH   A O   1 
HETATM 2295 O O   . HOH   G 5 .   ? -2.74030  77.64481 -20.51624 1.000 56.99376 ? 755 HOH   A O   1 
HETATM 2296 O O   . HOH   G 5 .   ? 15.78840  64.11164 8.31318   1.000 42.32216 ? 756 HOH   A O   1 
HETATM 2297 O O   . HOH   G 5 .   ? 2.67596   67.33651 -20.81138 1.000 56.97788 ? 757 HOH   A O   1 
HETATM 2298 O O   . HOH   G 5 .   ? -10.89843 74.60799 -0.73442  1.000 41.09433 ? 758 HOH   A O   1 
HETATM 2299 O O   . HOH   G 5 .   ? -3.34766  73.52942 -22.02635 1.000 56.89559 ? 759 HOH   A O   1 
HETATM 2300 O O   . HOH   G 5 .   ? -14.50921 57.50060 2.78691   1.000 46.04049 ? 760 HOH   A O   1 
HETATM 2301 O O   . HOH   G 5 .   ? -0.50400  59.90073 23.72532  1.000 60.23648 ? 761 HOH   A O   1 
HETATM 2302 O O   . HOH   G 5 .   ? 15.40897  56.11162 -1.61237  1.000 41.32575 ? 762 HOH   A O   1 
HETATM 2303 O O   . HOH   G 5 .   ? 0.39803   79.22632 12.39181  1.000 41.73181 ? 763 HOH   A O   1 
HETATM 2304 O O   . HOH   G 5 .   ? -7.65913  81.97792 16.09007  1.000 53.05908 ? 764 HOH   A O   1 
HETATM 2305 O O   . HOH   G 5 .   ? 11.04221  88.37396 9.70351   1.000 51.96689 ? 765 HOH   A O   1 
HETATM 2306 O O   . HOH   G 5 .   ? 3.27952   80.61438 10.33710  1.000 50.45721 ? 766 HOH   A O   1 
HETATM 2307 O O   . HOH   G 5 .   ? 5.40639   55.81675 -3.30812  1.000 49.57045 ? 767 HOH   A O   1 
HETATM 2308 O O   . HOH   G 5 .   ? -1.02299  83.02786 11.33476  1.000 52.74737 ? 768 HOH   A O   1 
HETATM 2309 O O   . HOH   G 5 .   ? 1.56297   85.03432 12.44253  1.000 54.24934 ? 769 HOH   A O   1 
HETATM 2310 O O   . HOH   G 5 .   ? -7.50801  64.91083 -9.17962  1.000 58.94960 ? 770 HOH   A O   1 
HETATM 2311 O O   . HOH   G 5 .   ? -9.05793  75.37202 -4.37616  1.000 49.35532 ? 771 HOH   A O   1 
HETATM 2312 O O   . HOH   G 5 .   ? 14.94311  67.66242 -14.73657 1.000 40.86889 ? 772 HOH   A O   1 
HETATM 2313 O O   . HOH   G 5 .   ? 21.61838  56.22828 -7.88983  1.000 63.01357 ? 773 HOH   A O   1 
HETATM 2314 O O   . HOH   G 5 .   ? -7.80548  89.04363 6.53727   1.000 33.84206 ? 774 HOH   A O   1 
HETATM 2315 O O   . HOH   G 5 .   ? 26.17756  78.75436 -12.39408 1.000 67.75862 ? 775 HOH   A O   1 
HETATM 2316 O O   . HOH   G 5 .   ? 8.333     49.205   17.810    1.000 39.08720 ? 776 HOH   A O   1 
HETATM 2317 O O   . HOH   G 5 .   ? 5.95212   61.40899 18.61871  1.000 42.91622 ? 777 HOH   A O   1 
HETATM 2318 O O   . HOH   G 5 .   ? 6.37998   51.01767 18.27228  1.000 42.21420 ? 778 HOH   A O   1 
HETATM 2319 O O   . HOH   G 5 .   ? 22.52504  60.36277 -4.29044  1.000 59.97506 ? 779 HOH   A O   1 
HETATM 2320 O O   . HOH   G 5 .   ? 10.071    41.536   14.276    1.000 52.25046 ? 780 HOH   A O   1 
HETATM 2321 O O   . HOH   G 5 .   ? 6.61156   78.67136 13.24078  1.000 50.26701 ? 781 HOH   A O   1 
HETATM 2322 O O   . HOH   G 5 .   ? -11.19245 77.65574 5.19090   1.000 58.38679 ? 782 HOH   A O   1 
HETATM 2323 O O   . HOH   G 5 .   ? 17.93454  63.80937 11.57346  1.000 59.95193 ? 783 HOH   A O   1 
HETATM 2324 O O   . HOH   G 5 .   ? -10.56998 82.40880 12.73650  1.000 50.57268 ? 784 HOH   A O   1 
HETATM 2325 O O   . HOH   G 5 .   ? 5.06551   53.08083 20.25716  1.000 46.33980 ? 785 HOH   A O   1 
HETATM 2326 O O   . HOH   G 5 .   ? 7.56278   87.08816 -12.64974 1.000 50.97111 ? 786 HOH   A O   1 
HETATM 2327 O O   . HOH   G 5 .   ? 17.45402  64.97749 -20.41226 1.000 61.59893 ? 787 HOH   A O   1 
HETATM 2328 O O   . HOH   G 5 .   ? 21.22384  58.46514 -2.24046  1.000 58.33274 ? 788 HOH   A O   1 
HETATM 2329 O O   . HOH   G 5 .   ? -12.54313 68.37384 -3.06170  1.000 47.07427 ? 789 HOH   A O   1 
HETATM 2330 O O   . HOH   G 5 .   ? 14.35116  58.11197 9.39002   1.000 47.61362 ? 790 HOH   A O   1 
HETATM 2331 O O   . HOH   G 5 .   ? 19.54118  58.06281 -0.32977  1.000 54.61878 ? 791 HOH   A O   1 
HETATM 2332 O O   . HOH   G 5 .   ? -7.99495  77.33148 -1.02701  1.000 45.00886 ? 792 HOH   A O   1 
HETATM 2333 O O   . HOH   G 5 .   ? -10.74520 59.39437 15.83585  1.000 47.33507 ? 793 HOH   A O   1 
HETATM 2334 O O   . HOH   G 5 .   ? 18.22131  56.86328 -12.08877 1.000 54.34512 ? 794 HOH   A O   1 
HETATM 2335 O O   . HOH   G 5 .   ? 15.17852  60.81508 11.77981  1.000 56.20015 ? 795 HOH   A O   1 
HETATM 2336 O O   . HOH   G 5 .   ? -5.54610  42.95532 3.46922   1.000 59.82028 ? 796 HOH   A O   1 
HETATM 2337 O O   . HOH   G 5 .   ? 0.58887   56.47447 20.45691  1.000 56.39587 ? 797 HOH   A O   1 
HETATM 2338 O O   . HOH   G 5 .   ? 6.65199   58.62096 19.02677  1.000 40.32611 ? 798 HOH   A O   1 
HETATM 2339 O O   . HOH   G 5 .   ? 3.78616   59.06757 19.53383  1.000 56.86458 ? 799 HOH   A O   1 
# 
