data_9FTX
# 
_entry.id   9FTX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FTX         pdb_00009ftx 10.2210/pdb9ftx/pdb 
WWPDB D_1292139721 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FTX 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Same citation' 9FTU unspecified 
PDB 'Same citation' 9FTS unspecified 
PDB 'Same citation' 9FTV unspecified 
# 
_pdbx_contact_author.id                 5 
_pdbx_contact_author.email              daniele.de_sanctis@esrf.fr 
_pdbx_contact_author.name_first         Daniele 
_pdbx_contact_author.name_last          'de Sanctis' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0391-8290 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Orlans, J.'     1 0000-0002-6933-2287 
'Rose, S.L.'     2 0000-0003-4824-4066 
'Basu, S.'       3 0000-0001-6484-8236 
'de Sanctis, D.' 4 0000-0003-0391-8290 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Commun Chem' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2399-3669 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            8 
_citation.language                  ? 
_citation.page_first                6 
_citation.page_last                 6 
_citation.title                     
'Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s42004-024-01404-y 
_citation.pdbx_database_id_PubMed   39775172 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Orlans, J.'        1  ?                   
primary 'Rose, S.L.'        2  0000-0003-4824-4066 
primary 'Ferguson, G.'      3  0000-0003-2551-5994 
primary 'Oscarsson, M.'     4  ?                   
primary 'Homs Puron, A.'    5  ?                   
primary 'Beteva, A.'        6  ?                   
primary 'Debionne, S.'      7  ?                   
primary 'Theveneau, P.'     8  ?                   
primary 'Coquelle, N.'      9  ?                   
primary 'Kieffer, J.'       10 0000-0002-0730-6577 
primary 'Busca, P.'         11 ?                   
primary 'Sinoir, J.'        12 ?                   
primary 'Armijo, V.'        13 0009-0006-3243-8391 
primary 'Lopez Marrero, M.' 14 ?                   
primary 'Felisaz, F.'       15 ?                   
primary 'Papp, G.'          16 0000-0002-5702-843X 
primary 'Gonzalez, H.'      17 ?                   
primary 'Caserotto, H.'     18 ?                   
primary 'Dobias, F.'        19 ?                   
primary 'Gigmes, J.'        20 ?                   
primary 'Lebon, G.'         21 0000-0003-1162-5148 
primary 'Basu, S.'          22 0000-0001-6484-8236 
primary 'de Sanctis, D.'    23 0000-0003-0391-8290 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Proteinase K' 28958.791 1   3.4.21.64 ? ? ? 
2 non-polymer syn 'CALCIUM ION'  40.078    2   ?         ? ? ? 
3 non-polymer nat 'NITRATE ION'  62.005    1   ?         ? ? ? 
4 water       nat water          18.015    189 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Endopeptidase K,Tritirachium alkaline proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSR
TYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAG
NNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGGSTRSISGTSMATPHVAGLAAYLMTL
GKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSR
TYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAG
NNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGGSTRSISGTSMATPHVAGLAAYLMTL
GKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION' CA  
3 'NITRATE ION' NO3 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ALA n 
1 3   GLN n 
1 4   THR n 
1 5   ASN n 
1 6   ALA n 
1 7   PRO n 
1 8   TRP n 
1 9   GLY n 
1 10  LEU n 
1 11  ALA n 
1 12  ARG n 
1 13  ILE n 
1 14  SER n 
1 15  SER n 
1 16  THR n 
1 17  SER n 
1 18  PRO n 
1 19  GLY n 
1 20  THR n 
1 21  SER n 
1 22  THR n 
1 23  TYR n 
1 24  TYR n 
1 25  TYR n 
1 26  ASP n 
1 27  GLU n 
1 28  SER n 
1 29  ALA n 
1 30  GLY n 
1 31  GLN n 
1 32  GLY n 
1 33  SER n 
1 34  CYS n 
1 35  VAL n 
1 36  TYR n 
1 37  VAL n 
1 38  ILE n 
1 39  ASP n 
1 40  THR n 
1 41  GLY n 
1 42  ILE n 
1 43  GLU n 
1 44  ALA n 
1 45  SER n 
1 46  HIS n 
1 47  PRO n 
1 48  GLU n 
1 49  PHE n 
1 50  GLU n 
1 51  GLY n 
1 52  ARG n 
1 53  ALA n 
1 54  GLN n 
1 55  MET n 
1 56  VAL n 
1 57  LYS n 
1 58  THR n 
1 59  TYR n 
1 60  TYR n 
1 61  TYR n 
1 62  SER n 
1 63  SER n 
1 64  ARG n 
1 65  ASP n 
1 66  GLY n 
1 67  ASN n 
1 68  GLY n 
1 69  HIS n 
1 70  GLY n 
1 71  THR n 
1 72  HIS n 
1 73  CYS n 
1 74  ALA n 
1 75  GLY n 
1 76  THR n 
1 77  VAL n 
1 78  GLY n 
1 79  SER n 
1 80  ARG n 
1 81  THR n 
1 82  TYR n 
1 83  GLY n 
1 84  VAL n 
1 85  ALA n 
1 86  LYS n 
1 87  LYS n 
1 88  THR n 
1 89  GLN n 
1 90  LEU n 
1 91  PHE n 
1 92  GLY n 
1 93  VAL n 
1 94  LYS n 
1 95  VAL n 
1 96  LEU n 
1 97  ASP n 
1 98  ASP n 
1 99  ASN n 
1 100 GLY n 
1 101 SER n 
1 102 GLY n 
1 103 GLN n 
1 104 TYR n 
1 105 SER n 
1 106 THR n 
1 107 ILE n 
1 108 ILE n 
1 109 ALA n 
1 110 GLY n 
1 111 MET n 
1 112 ASP n 
1 113 PHE n 
1 114 VAL n 
1 115 ALA n 
1 116 SER n 
1 117 ASP n 
1 118 LYS n 
1 119 ASN n 
1 120 ASN n 
1 121 ARG n 
1 122 ASN n 
1 123 CYS n 
1 124 PRO n 
1 125 LYS n 
1 126 GLY n 
1 127 VAL n 
1 128 VAL n 
1 129 ALA n 
1 130 SER n 
1 131 LEU n 
1 132 SER n 
1 133 LEU n 
1 134 GLY n 
1 135 GLY n 
1 136 GLY n 
1 137 TYR n 
1 138 SER n 
1 139 SER n 
1 140 SER n 
1 141 VAL n 
1 142 ASN n 
1 143 SER n 
1 144 ALA n 
1 145 ALA n 
1 146 ALA n 
1 147 ARG n 
1 148 LEU n 
1 149 GLN n 
1 150 SER n 
1 151 SER n 
1 152 GLY n 
1 153 VAL n 
1 154 MET n 
1 155 VAL n 
1 156 ALA n 
1 157 VAL n 
1 158 ALA n 
1 159 ALA n 
1 160 GLY n 
1 161 ASN n 
1 162 ASN n 
1 163 ASN n 
1 164 ALA n 
1 165 ASP n 
1 166 ALA n 
1 167 ARG n 
1 168 ASN n 
1 169 TYR n 
1 170 SER n 
1 171 PRO n 
1 172 ALA n 
1 173 SER n 
1 174 GLU n 
1 175 PRO n 
1 176 SER n 
1 177 VAL n 
1 178 CYS n 
1 179 THR n 
1 180 VAL n 
1 181 GLY n 
1 182 ALA n 
1 183 SER n 
1 184 ASP n 
1 185 ARG n 
1 186 TYR n 
1 187 ASP n 
1 188 ARG n 
1 189 ARG n 
1 190 SER n 
1 191 SER n 
1 192 PHE n 
1 193 SER n 
1 194 ASN n 
1 195 TYR n 
1 196 GLY n 
1 197 SER n 
1 198 VAL n 
1 199 LEU n 
1 200 ASP n 
1 201 ILE n 
1 202 PHE n 
1 203 GLY n 
1 204 PRO n 
1 205 GLY n 
1 206 THR n 
1 207 ASP n 
1 208 ILE n 
1 209 LEU n 
1 210 SER n 
1 211 THR n 
1 212 TRP n 
1 213 ILE n 
1 214 GLY n 
1 215 GLY n 
1 216 SER n 
1 217 THR n 
1 218 ARG n 
1 219 SER n 
1 220 ILE n 
1 221 SER n 
1 222 GLY n 
1 223 THR n 
1 224 SER n 
1 225 MET n 
1 226 ALA n 
1 227 THR n 
1 228 PRO n 
1 229 HIS n 
1 230 VAL n 
1 231 ALA n 
1 232 GLY n 
1 233 LEU n 
1 234 ALA n 
1 235 ALA n 
1 236 TYR n 
1 237 LEU n 
1 238 MET n 
1 239 THR n 
1 240 LEU n 
1 241 GLY n 
1 242 LYS n 
1 243 THR n 
1 244 THR n 
1 245 ALA n 
1 246 ALA n 
1 247 SER n 
1 248 ALA n 
1 249 CYS n 
1 250 ARG n 
1 251 TYR n 
1 252 ILE n 
1 253 ALA n 
1 254 ASP n 
1 255 THR n 
1 256 ALA n 
1 257 ASN n 
1 258 LYS n 
1 259 GLY n 
1 260 ASP n 
1 261 LEU n 
1 262 SER n 
1 263 ASN n 
1 264 ILE n 
1 265 PRO n 
1 266 PHE n 
1 267 GLY n 
1 268 THR n 
1 269 VAL n 
1 270 ASN n 
1 271 LEU n 
1 272 LEU n 
1 273 ALA n 
1 274 TYR n 
1 275 ASN n 
1 276 ASN n 
1 277 TYR n 
1 278 GLN n 
1 279 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   279 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PROK 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Parengyodontium album' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     37998 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
NO3 non-polymer         . 'NITRATE ION'   ? 'N O3 -1'        62.005  
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   1   ALA ALA A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   GLN 3   3   3   GLN GLN A . n 
A 1 4   THR 4   4   4   THR THR A . n 
A 1 5   ASN 5   5   5   ASN ASN A . n 
A 1 6   ALA 6   6   6   ALA ALA A . n 
A 1 7   PRO 7   7   7   PRO PRO A . n 
A 1 8   TRP 8   8   8   TRP TRP A . n 
A 1 9   GLY 9   9   9   GLY GLY A . n 
A 1 10  LEU 10  10  10  LEU LEU A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  ARG 12  12  12  ARG ARG A . n 
A 1 13  ILE 13  13  13  ILE ILE A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  THR 16  16  16  THR THR A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  GLY 19  19  19  GLY GLY A . n 
A 1 20  THR 20  20  20  THR THR A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  TYR 23  23  23  TYR TYR A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  TYR 25  25  25  TYR TYR A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  ALA 29  29  29  ALA ALA A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  GLN 31  31  31  GLN GLN A . n 
A 1 32  GLY 32  32  32  GLY GLY A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  CYS 34  34  34  CYS CYS A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  TYR 36  36  36  TYR TYR A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
A 1 40  THR 40  40  40  THR THR A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  ILE 42  42  42  ILE ILE A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  SER 45  45  45  SER SER A . n 
A 1 46  HIS 46  46  46  HIS HIS A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  GLU 48  48  48  GLU GLU A . n 
A 1 49  PHE 49  49  49  PHE PHE A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  GLY 51  51  51  GLY GLY A . n 
A 1 52  ARG 52  52  52  ARG ARG A . n 
A 1 53  ALA 53  53  53  ALA ALA A . n 
A 1 54  GLN 54  54  54  GLN GLN A . n 
A 1 55  MET 55  55  55  MET MET A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  THR 58  58  58  THR THR A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  TYR 60  60  60  TYR TYR A . n 
A 1 61  TYR 61  61  61  TYR TYR A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  SER 63  63  63  SER SER A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  ASP 65  65  65  ASP ASP A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  ASN 67  67  67  ASN ASN A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  HIS 72  72  72  HIS HIS A . n 
A 1 73  CYS 73  73  73  CYS CYS A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  THR 76  76  76  THR THR A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  GLY 78  78  78  GLY GLY A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  THR 81  81  81  THR THR A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  GLY 83  83  83  GLY GLY A . n 
A 1 84  VAL 84  84  84  VAL VAL A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  GLN 89  89  89  GLN GLN A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  PHE 91  91  91  PHE PHE A . n 
A 1 92  GLY 92  92  92  GLY GLY A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  ASP 97  97  97  ASP ASP A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  ASN 99  99  99  ASN ASN A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 GLN 103 103 103 GLN GLN A . n 
A 1 104 TYR 104 104 104 TYR TYR A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 ILE 107 107 107 ILE ILE A . n 
A 1 108 ILE 108 108 108 ILE ILE A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 GLY 110 110 110 GLY GLY A . n 
A 1 111 MET 111 111 111 MET MET A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 PHE 113 113 113 PHE PHE A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 ASP 117 117 117 ASP ASP A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 ASN 120 120 120 ASN ASN A . n 
A 1 121 ARG 121 121 121 ARG ARG A . n 
A 1 122 ASN 122 122 122 ASN ASN A . n 
A 1 123 CYS 123 123 123 CYS CYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 LYS 125 125 125 LYS LYS A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 SER 130 130 130 SER SER A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 GLY 134 134 134 GLY GLY A . n 
A 1 135 GLY 135 135 135 GLY GLY A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 TYR 137 137 137 TYR TYR A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 SER 140 140 140 SER SER A . n 
A 1 141 VAL 141 141 141 VAL VAL A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 ARG 147 147 147 ARG ARG A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 GLN 149 149 149 GLN GLN A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 SER 151 151 151 SER SER A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 MET 154 154 154 MET MET A . n 
A 1 155 VAL 155 155 155 VAL VAL A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 GLY 160 160 160 GLY GLY A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 ASN 163 163 163 ASN ASN A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 ASP 165 165 165 ASP ASP A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ARG 167 167 167 ARG ARG A . n 
A 1 168 ASN 168 168 168 ASN ASN A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 GLU 174 174 174 GLU GLU A . n 
A 1 175 PRO 175 175 175 PRO PRO A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 CYS 178 178 178 CYS CYS A . n 
A 1 179 THR 179 179 179 THR THR A . n 
A 1 180 VAL 180 180 180 VAL VAL A . n 
A 1 181 GLY 181 181 181 GLY GLY A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 ASP 184 184 184 ASP ASP A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 TYR 186 186 186 TYR TYR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 SER 190 190 190 SER SER A . n 
A 1 191 SER 191 191 191 SER SER A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ASN 194 194 194 ASN ASN A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 VAL 198 198 198 VAL VAL A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 ASP 200 200 200 ASP ASP A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 GLY 203 203 203 GLY GLY A . n 
A 1 204 PRO 204 204 204 PRO PRO A . n 
A 1 205 GLY 205 205 205 GLY GLY A . n 
A 1 206 THR 206 206 206 THR THR A . n 
A 1 207 ASP 207 207 207 ASP ASP A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 SER 210 210 210 SER SER A . n 
A 1 211 THR 211 211 211 THR THR A . n 
A 1 212 TRP 212 212 212 TRP TRP A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 GLY 214 214 214 GLY GLY A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 THR 217 217 217 THR THR A . n 
A 1 218 ARG 218 218 218 ARG ARG A . n 
A 1 219 SER 219 219 219 SER SER A . n 
A 1 220 ILE 220 220 220 ILE ILE A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 GLY 222 222 222 GLY GLY A . n 
A 1 223 THR 223 223 223 THR THR A . n 
A 1 224 SER 224 224 224 SER SER A . n 
A 1 225 MET 225 225 225 MET MET A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 THR 227 227 227 THR THR A . n 
A 1 228 PRO 228 228 228 PRO PRO A . n 
A 1 229 HIS 229 229 229 HIS HIS A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 TYR 236 236 236 TYR TYR A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 MET 238 238 238 MET MET A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLY 241 241 241 GLY GLY A . n 
A 1 242 LYS 242 242 242 LYS LYS A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 THR 244 244 244 THR THR A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 SER 247 247 247 SER SER A . n 
A 1 248 ALA 248 248 248 ALA ALA A . n 
A 1 249 CYS 249 249 249 CYS CYS A . n 
A 1 250 ARG 250 250 250 ARG ARG A . n 
A 1 251 TYR 251 251 251 TYR TYR A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 ALA 253 253 253 ALA ALA A . n 
A 1 254 ASP 254 254 254 ASP ASP A . n 
A 1 255 THR 255 255 255 THR THR A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 ASN 257 257 257 ASN ASN A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 GLY 259 259 259 GLY GLY A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 ASN 263 263 263 ASN ASN A . n 
A 1 264 ILE 264 264 264 ILE ILE A . n 
A 1 265 PRO 265 265 265 PRO PRO A . n 
A 1 266 PHE 266 266 266 PHE PHE A . n 
A 1 267 GLY 267 267 267 GLY GLY A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 VAL 269 269 269 VAL VAL A . n 
A 1 270 ASN 270 270 270 ASN ASN A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 TYR 274 274 274 TYR TYR A . n 
A 1 275 ASN 275 275 275 ASN ASN A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 TYR 277 277 277 TYR TYR A . n 
A 1 278 GLN 278 278 278 GLN GLN A . n 
A 1 279 ALA 279 279 279 ALA ALA A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CA  1   501 501 CA  CA  A . 
C 2 CA  1   502 502 CA  CA  A . 
D 3 NO3 1   503 503 NO3 NO3 A . 
E 4 HOH 1   601 243 HOH HOH A . 
E 4 HOH 2   602 371 HOH HOH A . 
E 4 HOH 3   603 251 HOH HOH A . 
E 4 HOH 4   604 70  HOH HOH A . 
E 4 HOH 5   605 249 HOH HOH A . 
E 4 HOH 6   606 452 HOH HOH A . 
E 4 HOH 7   607 192 HOH HOH A . 
E 4 HOH 8   608 100 HOH HOH A . 
E 4 HOH 9   609 93  HOH HOH A . 
E 4 HOH 10  610 239 HOH HOH A . 
E 4 HOH 11  611 203 HOH HOH A . 
E 4 HOH 12  612 256 HOH HOH A . 
E 4 HOH 13  613 294 HOH HOH A . 
E 4 HOH 14  614 4   HOH HOH A . 
E 4 HOH 15  615 64  HOH HOH A . 
E 4 HOH 16  616 108 HOH HOH A . 
E 4 HOH 17  617 29  HOH HOH A . 
E 4 HOH 18  618 82  HOH HOH A . 
E 4 HOH 19  619 9   HOH HOH A . 
E 4 HOH 20  620 362 HOH HOH A . 
E 4 HOH 21  621 141 HOH HOH A . 
E 4 HOH 22  622 272 HOH HOH A . 
E 4 HOH 23  623 392 HOH HOH A . 
E 4 HOH 24  624 39  HOH HOH A . 
E 4 HOH 25  625 111 HOH HOH A . 
E 4 HOH 26  626 3   HOH HOH A . 
E 4 HOH 27  627 51  HOH HOH A . 
E 4 HOH 28  628 135 HOH HOH A . 
E 4 HOH 29  629 43  HOH HOH A . 
E 4 HOH 30  630 293 HOH HOH A . 
E 4 HOH 31  631 28  HOH HOH A . 
E 4 HOH 32  632 37  HOH HOH A . 
E 4 HOH 33  633 56  HOH HOH A . 
E 4 HOH 34  634 44  HOH HOH A . 
E 4 HOH 35  635 1   HOH HOH A . 
E 4 HOH 36  636 137 HOH HOH A . 
E 4 HOH 37  637 90  HOH HOH A . 
E 4 HOH 38  638 49  HOH HOH A . 
E 4 HOH 39  639 2   HOH HOH A . 
E 4 HOH 40  640 38  HOH HOH A . 
E 4 HOH 41  641 27  HOH HOH A . 
E 4 HOH 42  642 153 HOH HOH A . 
E 4 HOH 43  643 12  HOH HOH A . 
E 4 HOH 44  644 375 HOH HOH A . 
E 4 HOH 45  645 21  HOH HOH A . 
E 4 HOH 46  646 6   HOH HOH A . 
E 4 HOH 47  647 26  HOH HOH A . 
E 4 HOH 48  648 20  HOH HOH A . 
E 4 HOH 49  649 46  HOH HOH A . 
E 4 HOH 50  650 24  HOH HOH A . 
E 4 HOH 51  651 5   HOH HOH A . 
E 4 HOH 52  652 36  HOH HOH A . 
E 4 HOH 53  653 254 HOH HOH A . 
E 4 HOH 54  654 35  HOH HOH A . 
E 4 HOH 55  655 13  HOH HOH A . 
E 4 HOH 56  656 50  HOH HOH A . 
E 4 HOH 57  657 15  HOH HOH A . 
E 4 HOH 58  658 52  HOH HOH A . 
E 4 HOH 59  659 78  HOH HOH A . 
E 4 HOH 60  660 186 HOH HOH A . 
E 4 HOH 61  661 333 HOH HOH A . 
E 4 HOH 62  662 16  HOH HOH A . 
E 4 HOH 63  663 65  HOH HOH A . 
E 4 HOH 64  664 147 HOH HOH A . 
E 4 HOH 65  665 149 HOH HOH A . 
E 4 HOH 66  666 14  HOH HOH A . 
E 4 HOH 67  667 31  HOH HOH A . 
E 4 HOH 68  668 33  HOH HOH A . 
E 4 HOH 69  669 265 HOH HOH A . 
E 4 HOH 70  670 288 HOH HOH A . 
E 4 HOH 71  671 17  HOH HOH A . 
E 4 HOH 72  672 326 HOH HOH A . 
E 4 HOH 73  673 79  HOH HOH A . 
E 4 HOH 74  674 194 HOH HOH A . 
E 4 HOH 75  675 59  HOH HOH A . 
E 4 HOH 76  676 101 HOH HOH A . 
E 4 HOH 77  677 42  HOH HOH A . 
E 4 HOH 78  678 45  HOH HOH A . 
E 4 HOH 79  679 390 HOH HOH A . 
E 4 HOH 80  680 126 HOH HOH A . 
E 4 HOH 81  681 19  HOH HOH A . 
E 4 HOH 82  682 262 HOH HOH A . 
E 4 HOH 83  683 441 HOH HOH A . 
E 4 HOH 84  684 47  HOH HOH A . 
E 4 HOH 85  685 11  HOH HOH A . 
E 4 HOH 86  686 60  HOH HOH A . 
E 4 HOH 87  687 241 HOH HOH A . 
E 4 HOH 88  688 30  HOH HOH A . 
E 4 HOH 89  689 57  HOH HOH A . 
E 4 HOH 90  690 34  HOH HOH A . 
E 4 HOH 91  691 119 HOH HOH A . 
E 4 HOH 92  692 306 HOH HOH A . 
E 4 HOH 93  693 252 HOH HOH A . 
E 4 HOH 94  694 384 HOH HOH A . 
E 4 HOH 95  695 41  HOH HOH A . 
E 4 HOH 96  696 345 HOH HOH A . 
E 4 HOH 97  697 167 HOH HOH A . 
E 4 HOH 98  698 229 HOH HOH A . 
E 4 HOH 99  699 53  HOH HOH A . 
E 4 HOH 100 700 32  HOH HOH A . 
E 4 HOH 101 701 99  HOH HOH A . 
E 4 HOH 102 702 434 HOH HOH A . 
E 4 HOH 103 703 231 HOH HOH A . 
E 4 HOH 104 704 175 HOH HOH A . 
E 4 HOH 105 705 216 HOH HOH A . 
E 4 HOH 106 706 55  HOH HOH A . 
E 4 HOH 107 707 313 HOH HOH A . 
E 4 HOH 108 708 23  HOH HOH A . 
E 4 HOH 109 709 40  HOH HOH A . 
E 4 HOH 110 710 195 HOH HOH A . 
E 4 HOH 111 711 18  HOH HOH A . 
E 4 HOH 112 712 92  HOH HOH A . 
E 4 HOH 113 713 414 HOH HOH A . 
E 4 HOH 114 714 164 HOH HOH A . 
E 4 HOH 115 715 287 HOH HOH A . 
E 4 HOH 116 716 8   HOH HOH A . 
E 4 HOH 117 717 61  HOH HOH A . 
E 4 HOH 118 718 190 HOH HOH A . 
E 4 HOH 119 719 10  HOH HOH A . 
E 4 HOH 120 720 58  HOH HOH A . 
E 4 HOH 121 721 303 HOH HOH A . 
E 4 HOH 122 722 405 HOH HOH A . 
E 4 HOH 123 723 336 HOH HOH A . 
E 4 HOH 124 724 160 HOH HOH A . 
E 4 HOH 125 725 162 HOH HOH A . 
E 4 HOH 126 726 459 HOH HOH A . 
E 4 HOH 127 727 62  HOH HOH A . 
E 4 HOH 128 728 210 HOH HOH A . 
E 4 HOH 129 729 246 HOH HOH A . 
E 4 HOH 130 730 346 HOH HOH A . 
E 4 HOH 131 731 84  HOH HOH A . 
E 4 HOH 132 732 66  HOH HOH A . 
E 4 HOH 133 733 77  HOH HOH A . 
E 4 HOH 134 734 128 HOH HOH A . 
E 4 HOH 135 735 191 HOH HOH A . 
E 4 HOH 136 736 348 HOH HOH A . 
E 4 HOH 137 737 7   HOH HOH A . 
E 4 HOH 138 738 411 HOH HOH A . 
E 4 HOH 139 739 356 HOH HOH A . 
E 4 HOH 140 740 80  HOH HOH A . 
E 4 HOH 141 741 142 HOH HOH A . 
E 4 HOH 142 742 217 HOH HOH A . 
E 4 HOH 143 743 25  HOH HOH A . 
E 4 HOH 144 744 205 HOH HOH A . 
E 4 HOH 145 745 264 HOH HOH A . 
E 4 HOH 146 746 198 HOH HOH A . 
E 4 HOH 147 747 438 HOH HOH A . 
E 4 HOH 148 748 464 HOH HOH A . 
E 4 HOH 149 749 387 HOH HOH A . 
E 4 HOH 150 750 450 HOH HOH A . 
E 4 HOH 151 751 421 HOH HOH A . 
E 4 HOH 152 752 156 HOH HOH A . 
E 4 HOH 153 753 463 HOH HOH A . 
E 4 HOH 154 754 146 HOH HOH A . 
E 4 HOH 155 755 22  HOH HOH A . 
E 4 HOH 156 756 322 HOH HOH A . 
E 4 HOH 157 757 448 HOH HOH A . 
E 4 HOH 158 758 240 HOH HOH A . 
E 4 HOH 159 759 242 HOH HOH A . 
E 4 HOH 160 760 247 HOH HOH A . 
E 4 HOH 161 761 266 HOH HOH A . 
E 4 HOH 162 762 150 HOH HOH A . 
E 4 HOH 163 763 304 HOH HOH A . 
E 4 HOH 164 764 317 HOH HOH A . 
E 4 HOH 165 765 285 HOH HOH A . 
E 4 HOH 166 766 196 HOH HOH A . 
E 4 HOH 167 767 300 HOH HOH A . 
E 4 HOH 168 768 165 HOH HOH A . 
E 4 HOH 169 769 171 HOH HOH A . 
E 4 HOH 170 770 323 HOH HOH A . 
E 4 HOH 171 771 89  HOH HOH A . 
E 4 HOH 172 772 283 HOH HOH A . 
E 4 HOH 173 773 397 HOH HOH A . 
E 4 HOH 174 774 213 HOH HOH A . 
E 4 HOH 175 775 407 HOH HOH A . 
E 4 HOH 176 776 276 HOH HOH A . 
E 4 HOH 177 777 325 HOH HOH A . 
E 4 HOH 178 778 425 HOH HOH A . 
E 4 HOH 179 779 170 HOH HOH A . 
E 4 HOH 180 780 301 HOH HOH A . 
E 4 HOH 181 781 461 HOH HOH A . 
E 4 HOH 182 782 462 HOH HOH A . 
E 4 HOH 183 783 134 HOH HOH A . 
E 4 HOH 184 784 106 HOH HOH A . 
E 4 HOH 185 785 221 HOH HOH A . 
E 4 HOH 186 786 187 HOH HOH A . 
E 4 HOH 187 787 430 HOH HOH A . 
E 4 HOH 188 788 176 HOH HOH A . 
E 4 HOH 189 789 117 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLN 31  ? CG  ? A GLN 31  CG  
2  1 Y 1 A GLN 31  ? CD  ? A GLN 31  CD  
3  1 Y 1 A GLN 31  ? OE1 ? A GLN 31  OE1 
4  1 Y 1 A GLN 31  ? NE2 ? A GLN 31  NE2 
5  1 Y 1 A ARG 64  ? CG  ? A ARG 64  CG  
6  1 Y 1 A ARG 64  ? CD  ? A ARG 64  CD  
7  1 Y 1 A ARG 64  ? NE  ? A ARG 64  NE  
8  1 Y 1 A ARG 64  ? CZ  ? A ARG 64  CZ  
9  1 Y 1 A ARG 64  ? NH1 ? A ARG 64  NH1 
10 1 Y 1 A ARG 64  ? NH2 ? A ARG 64  NH2 
11 1 Y 1 A GLN 89  ? CG  ? A GLN 89  CG  
12 1 Y 1 A GLN 89  ? CD  ? A GLN 89  CD  
13 1 Y 1 A GLN 89  ? OE1 ? A GLN 89  OE1 
14 1 Y 1 A GLN 89  ? NE2 ? A GLN 89  NE2 
15 1 Y 1 A GLN 103 ? CG  ? A GLN 103 CG  
16 1 Y 1 A GLN 103 ? CD  ? A GLN 103 CD  
17 1 Y 1 A GLN 103 ? OE1 ? A GLN 103 OE1 
18 1 Y 1 A GLN 103 ? NE2 ? A GLN 103 NE2 
19 1 Y 1 A ARG 167 ? CG  ? A ARG 167 CG  
20 1 Y 1 A ARG 167 ? CD  ? A ARG 167 CD  
21 1 Y 1 A ARG 167 ? NE  ? A ARG 167 NE  
22 1 Y 1 A ARG 167 ? CZ  ? A ARG 167 CZ  
23 1 Y 1 A ARG 167 ? NH1 ? A ARG 167 NH1 
24 1 Y 1 A ARG 167 ? NH2 ? A ARG 167 NH2 
25 1 Y 1 A ARG 250 ? CG  ? A ARG 250 CG  
26 1 Y 1 A ARG 250 ? CD  ? A ARG 250 CD  
27 1 Y 1 A ARG 250 ? NE  ? A ARG 250 NE  
28 1 Y 1 A ARG 250 ? CZ  ? A ARG 250 CZ  
29 1 Y 1 A ARG 250 ? NH1 ? A ARG 250 NH1 
30 1 Y 1 A ARG 250 ? NH2 ? A ARG 250 NH2 
31 1 Y 1 A GLN 278 ? CG  ? A GLN 278 CG  
32 1 Y 1 A GLN 278 ? CD  ? A GLN 278 CD  
33 1 Y 1 A GLN 278 ? OE1 ? A GLN 278 OE1 
34 1 Y 1 A GLN 278 ? NE2 ? A GLN 278 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FTX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     68.720 
_cell.length_a_esd                 ? 
_cell.length_b                     68.720 
_cell.length_b_esd                 ? 
_cell.length_c                     108.970 
_cell.length_c_esd                 ? 
_cell.volume                       514604.112 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FTX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FTX 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.26 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          62.21 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MES pH 6.5, 0.5 M sodium nitrate, 0.1 M calcium chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'PSI JUNGFRAU 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.072 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID29' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.072 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID29 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          18.92 
_reflns.entry_id                                       9FTX 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2 
_reflns.d_resolution_low                               58.13 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18372 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                221 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.24 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   0.984 
_reflns.pdbx_R_split                                   0.2175 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2 
_reflns_shell.d_res_low                                     2.03 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             890 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  0.8173 
_reflns_shell.pdbx_R_split                                  1.05 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               18.08 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FTX 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             58.13 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     18304 
_refine.ls_number_reflns_R_free                  1831 
_refine.ls_number_reflns_R_work                  16473 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.94 
_refine.ls_percent_reflns_R_free                 10.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2225 
_refine.ls_R_factor_R_free                       0.2623 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2182 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.2844 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2917 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        58.13 
_refine_hist.number_atoms_solvent             189 
_refine_hist.number_atoms_total               2193 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1998 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         6 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0017  ? 2040 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.4448  ? 2777 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0399  ? 312  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0028  ? 366  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.7409 ? 691  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.05  . . 138 1241 99.71  . . . . 0.3280 . . . . . . . . . . . 0.3383 
'X-RAY DIFFRACTION' 2.05 2.11  . . 139 1254 100.00 . . . . 0.3014 . . . . . . . . . . . 0.3440 
'X-RAY DIFFRACTION' 2.11 2.18  . . 136 1222 100.00 . . . . 0.2783 . . . . . . . . . . . 0.3503 
'X-RAY DIFFRACTION' 2.18 2.26  . . 138 1241 100.00 . . . . 0.2573 . . . . . . . . . . . 0.3164 
'X-RAY DIFFRACTION' 2.26 2.35  . . 139 1244 100.00 . . . . 0.2333 . . . . . . . . . . . 0.3151 
'X-RAY DIFFRACTION' 2.35 2.46  . . 139 1248 100.00 . . . . 0.2262 . . . . . . . . . . . 0.2494 
'X-RAY DIFFRACTION' 2.46 2.59  . . 138 1252 100.00 . . . . 0.2176 . . . . . . . . . . . 0.2796 
'X-RAY DIFFRACTION' 2.59 2.75  . . 141 1265 99.86  . . . . 0.2187 . . . . . . . . . . . 0.3089 
'X-RAY DIFFRACTION' 2.75 2.96  . . 139 1250 99.93  . . . . 0.2151 . . . . . . . . . . . 0.2456 
'X-RAY DIFFRACTION' 2.96 3.26  . . 142 1274 100.00 . . . . 0.2101 . . . . . . . . . . . 0.2519 
'X-RAY DIFFRACTION' 3.26 3.73  . . 142 1278 99.93  . . . . 0.1879 . . . . . . . . . . . 0.2285 
'X-RAY DIFFRACTION' 3.73 4.70  . . 145 1304 100.00 . . . . 0.1715 . . . . . . . . . . . 0.2095 
'X-RAY DIFFRACTION' 4.70 58.13 . . 155 1400 99.81  . . . . 0.2051 . . . . . . . . . . . 0.2283 
# 
_struct.entry_id                     9FTX 
_struct.title                        
'Serial microseconds crystallography at ID29 using fixed-target (small foils): Proteinase K with 10 um spacing between X-ray pulses' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FTX 
_struct_keywords.text            
'Serial crystallography, serial microsecond crystallography, room temperature, ID29, ESRF-EBS, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PRTK_PARAQ 
_struct_ref.pdbx_db_accession          P06873 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSR
TYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAG
NNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTL
GKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_struct_ref.pdbx_align_begin           106 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FTX 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 279 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P06873 
_struct_ref_seq.db_align_beg                  106 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  384 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       279 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9FTX 
_struct_ref_seq_dif.mon_id                       ASP 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      207 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P06873 
_struct_ref_seq_dif.db_mon_id                    SER 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          312 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            207 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 7   ? SER A 14  ? PRO A 7   SER A 14  1 ? 8  
HELX_P HELX_P2  AA2 HIS A 46  ? GLU A 50  ? HIS A 46  GLU A 50  5 ? 5  
HELX_P HELX_P3  AA3 GLY A 68  ? SER A 79  ? GLY A 68  SER A 79  1 ? 12 
HELX_P HELX_P4  AA4 GLN A 103 ? LYS A 118 ? GLN A 103 LYS A 118 1 ? 16 
HELX_P HELX_P5  AA5 ASN A 119 ? ARG A 121 ? ASN A 119 ARG A 121 5 ? 3  
HELX_P HELX_P6  AA6 SER A 138 ? SER A 151 ? SER A 138 SER A 151 1 ? 14 
HELX_P HELX_P7  AA7 ASP A 165 ? ARG A 167 ? ASP A 165 ARG A 167 5 ? 3  
HELX_P HELX_P8  AA8 ILE A 213 ? GLY A 215 ? ILE A 213 GLY A 215 5 ? 3  
HELX_P HELX_P9  AA9 GLY A 222 ? GLY A 241 ? GLY A 222 GLY A 241 1 ? 20 
HELX_P HELX_P10 AB1 SER A 247 ? THR A 255 ? SER A 247 THR A 255 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 34  SG  ? ? ? 1_555 A CYS 123 SG ? ? A CYS 34  A CYS 123 1_555 ? ? ? ? ? ? ? 2.029 ? ? 
disulf2  disulf ? ? A CYS 178 SG  ? ? ? 1_555 A CYS 249 SG ? ? A CYS 178 A CYS 249 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
metalc1  metalc ? ? A THR 16  O   ? ? ? 1_555 C CA  .   CA ? ? A THR 16  A CA  502 1_555 ? ? ? ? ? ? ? 2.356 ? ? 
metalc2  metalc ? ? A PRO 175 O   ? ? ? 1_555 B CA  .   CA ? ? A PRO 175 A CA  501 1_555 ? ? ? ? ? ? ? 2.373 ? ? 
metalc3  metalc ? ? A VAL 177 O   ? ? ? 1_555 B CA  .   CA ? ? A VAL 177 A CA  501 1_555 ? ? ? ? ? ? ? 2.396 ? ? 
metalc4  metalc ? ? A ASP 200 OD1 ? ? ? 1_555 B CA  .   CA ? ? A ASP 200 A CA  501 1_555 ? ? ? ? ? ? ? 2.636 ? ? 
metalc5  metalc ? ? A ASP 200 OD2 ? ? ? 1_555 B CA  .   CA ? ? A ASP 200 A CA  501 1_555 ? ? ? ? ? ? ? 2.414 ? ? 
metalc6  metalc ? ? A ASP 260 OD1 ? ? ? 1_555 C CA  .   CA ? ? A ASP 260 A CA  502 1_555 ? ? ? ? ? ? ? 2.704 ? ? 
metalc7  metalc ? ? A ASP 260 OD2 ? ? ? 1_555 C CA  .   CA ? ? A ASP 260 A CA  502 1_555 ? ? ? ? ? ? ? 2.322 ? ? 
metalc8  metalc ? ? B CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  501 A HOH 635 1_555 ? ? ? ? ? ? ? 2.583 ? ? 
metalc9  metalc ? ? B CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  501 A HOH 645 1_555 ? ? ? ? ? ? ? 2.749 ? ? 
metalc10 metalc ? ? B CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  501 A HOH 719 1_555 ? ? ? ? ? ? ? 2.552 ? ? 
metalc11 metalc ? ? B CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  501 A HOH 737 1_555 ? ? ? ? ? ? ? 2.655 ? ? 
metalc12 metalc ? ? C CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  502 A HOH 619 1_555 ? ? ? ? ? ? ? 2.390 ? ? 
metalc13 metalc ? ? C CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  502 A HOH 726 1_555 ? ? ? ? ? ? ? 2.709 ? ? 
metalc14 metalc ? ? C CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  502 A HOH 751 1_555 ? ? ? ? ? ? ? 2.660 ? ? 
metalc15 metalc ? ? C CA  .   CA  ? ? ? 1_555 E HOH .   O  ? ? A CA  502 A HOH 755 1_555 ? ? ? ? ? ? ? 2.382 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 OD1 ? A ASP 260 ? A ASP 260 ? 1_555 132.7 ? 
2  O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 OD2 ? A ASP 260 ? A ASP 260 ? 1_555 82.5  ? 
3  OD1 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 OD2 ? A ASP 260 ? A ASP 260 ? 1_555 51.1  ? 
4  O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 619 ? 1_555 87.2  ? 
5  OD1 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 619 ? 1_555 89.4  ? 
6  OD2 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 619 ? 1_555 76.3  ? 
7  O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 726 ? 1_555 158.3 ? 
8  OD1 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 726 ? 1_555 67.8  ? 
9  OD2 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 726 ? 1_555 115.8 ? 
10 O   ? E HOH .   ? A HOH 619 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 726 ? 1_555 86.1  ? 
11 O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 751 ? 1_555 80.1  ? 
12 OD1 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 751 ? 1_555 146.2 ? 
13 OD2 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 751 ? 1_555 154.2 ? 
14 O   ? E HOH .   ? A HOH 619 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 751 ? 1_555 84.0  ? 
15 O   ? E HOH .   ? A HOH 726 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 751 ? 1_555 78.7  ? 
16 O   ? A THR 16  ? A THR 16  ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 86.7  ? 
17 OD1 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 92.2  ? 
18 OD2 ? A ASP 260 ? A ASP 260 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 99.5  ? 
19 O   ? E HOH .   ? A HOH 619 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 172.9 ? 
20 O   ? E HOH .   ? A HOH 726 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 100.9 ? 
21 O   ? E HOH .   ? A HOH 751 ? 1_555 CA ? C CA . ? A CA 502 ? 1_555 O   ? E HOH .   ? A HOH 755 ? 1_555 98.3  ? 
22 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? A VAL 177 ? A VAL 177 ? 1_555 84.5  ? 
23 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 150.0 ? 
24 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 120.2 ? 
25 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 158.0 ? 
26 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 82.2  ? 
27 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 51.2  ? 
28 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 635 ? 1_555 81.0  ? 
29 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 635 ? 1_555 73.5  ? 
30 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 635 ? 1_555 120.3 ? 
31 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 635 ? 1_555 78.5  ? 
32 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 645 ? 1_555 95.1  ? 
33 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 645 ? 1_555 150.5 ? 
34 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 645 ? 1_555 72.0  ? 
35 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 645 ? 1_555 88.0  ? 
36 O   ? E HOH .   ? A HOH 635 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 645 ? 1_555 77.2  ? 
37 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 89.5  ? 
38 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 74.3  ? 
39 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 82.2  ? 
40 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 103.6 ? 
41 O   ? E HOH .   ? A HOH 635 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 147.1 ? 
42 O   ? E HOH .   ? A HOH 645 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 719 ? 1_555 135.3 ? 
43 O   ? A PRO 175 ? A PRO 175 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 79.1  ? 
44 O   ? A VAL 177 ? A VAL 177 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 139.3 ? 
45 OD1 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 71.0  ? 
46 OD2 ? A ASP 200 ? A ASP 200 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 122.0 ? 
47 O   ? E HOH .   ? A HOH 635 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 138.3 ? 
48 O   ? E HOH .   ? A HOH 645 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 68.6  ? 
49 O   ? E HOH .   ? A HOH 719 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? E HOH .   ? A HOH 737 ? 1_555 68.7  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 34  ? CYS A 123 ? CYS A 34  ? 1_555 CYS A 123 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 178 ? CYS A 249 ? CYS A 178 ? 1_555 CYS A 249 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          SER 
_struct_mon_prot_cis.label_seq_id           170 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           SER 
_struct_mon_prot_cis.auth_seq_id            170 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    171 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     171 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.56 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 7 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 2   ? GLN A 3   ? ALA A 2   GLN A 3   
AA1 2 TYR A 23  ? TYR A 24  ? TYR A 23  TYR A 24  
AA2 1 ALA A 53  ? THR A 58  ? ALA A 53  THR A 58  
AA2 2 GLN A 89  ? LYS A 94  ? GLN A 89  LYS A 94  
AA2 3 SER A 33  ? ASP A 39  ? SER A 33  ASP A 39  
AA2 4 GLY A 126 ? LEU A 131 ? GLY A 126 LEU A 131 
AA2 5 MET A 154 ? ALA A 158 ? MET A 154 ALA A 158 
AA2 6 CYS A 178 ? SER A 183 ? CYS A 178 SER A 183 
AA2 7 ILE A 201 ? PRO A 204 ? ILE A 201 PRO A 204 
AA3 1 GLY A 135 ? GLY A 136 ? GLY A 135 GLY A 136 
AA3 2 TYR A 169 ? SER A 170 ? TYR A 169 SER A 170 
AA4 1 ILE A 208 ? TRP A 212 ? ILE A 208 TRP A 212 
AA4 2 SER A 216 ? ILE A 220 ? SER A 216 ILE A 220 
AA5 1 ASN A 257 ? LYS A 258 ? ASN A 257 LYS A 258 
AA5 2 LEU A 271 ? LEU A 272 ? LEU A 271 LEU A 272 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 3   ? N GLN A 3   O TYR A 23  ? O TYR A 23  
AA2 1 2 N LYS A 57  ? N LYS A 57  O LYS A 94  ? O LYS A 94  
AA2 2 3 O PHE A 91  ? O PHE A 91  N VAL A 37  ? N VAL A 37  
AA2 3 4 N TYR A 36  ? N TYR A 36  O VAL A 128 ? O VAL A 128 
AA2 4 5 N LEU A 131 ? N LEU A 131 O ALA A 156 ? O ALA A 156 
AA2 5 6 N VAL A 157 ? N VAL A 157 O CYS A 178 ? O CYS A 178 
AA2 6 7 N GLY A 181 ? N GLY A 181 O ILE A 201 ? O ILE A 201 
AA3 1 2 N GLY A 135 ? N GLY A 135 O SER A 170 ? O SER A 170 
AA4 1 2 N ILE A 208 ? N ILE A 208 O ILE A 220 ? O ILE A 220 
AA5 1 2 N ASN A 257 ? N ASN A 257 O LEU A 272 ? O LEU A 272 
# 
_pdbx_entry_details.entry_id                   9FTX 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 112 ? ? O A HOH 601 ? ? 2.14 
2 1 O   A ASP 165 ? ? O A HOH 602 ? ? 2.14 
3 1 O   A HOH 602 ? ? O A HOH 682 ? ? 2.17 
4 1 O   A HOH 746 ? ? O A HOH 787 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 39  ? ? -159.78 -139.38 
2 1 TYR A 60  ? ? -129.98 -167.15 
3 1 ASN A 270 ? ? -110.83 75.52   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 684 ? E HOH . 
2 1 A HOH 779 ? E HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+1/4  
3 y+1/2,-x+1/2,z+3/4  
4 x+1/2,-y+1/2,-z+3/4 
5 -x+1/2,y+1/2,-z+1/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       789 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.91 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
NO3 N    N  N N 251 
NO3 O1   O  N N 252 
NO3 O2   O  N N 253 
NO3 O3   O  N N 254 
PHE N    N  N N 255 
PHE CA   C  N S 256 
PHE C    C  N N 257 
PHE O    O  N N 258 
PHE CB   C  N N 259 
PHE CG   C  Y N 260 
PHE CD1  C  Y N 261 
PHE CD2  C  Y N 262 
PHE CE1  C  Y N 263 
PHE CE2  C  Y N 264 
PHE CZ   C  Y N 265 
PHE OXT  O  N N 266 
PHE H    H  N N 267 
PHE H2   H  N N 268 
PHE HA   H  N N 269 
PHE HB2  H  N N 270 
PHE HB3  H  N N 271 
PHE HD1  H  N N 272 
PHE HD2  H  N N 273 
PHE HE1  H  N N 274 
PHE HE2  H  N N 275 
PHE HZ   H  N N 276 
PHE HXT  H  N N 277 
PRO N    N  N N 278 
PRO CA   C  N S 279 
PRO C    C  N N 280 
PRO O    O  N N 281 
PRO CB   C  N N 282 
PRO CG   C  N N 283 
PRO CD   C  N N 284 
PRO OXT  O  N N 285 
PRO H    H  N N 286 
PRO HA   H  N N 287 
PRO HB2  H  N N 288 
PRO HB3  H  N N 289 
PRO HG2  H  N N 290 
PRO HG3  H  N N 291 
PRO HD2  H  N N 292 
PRO HD3  H  N N 293 
PRO HXT  H  N N 294 
SER N    N  N N 295 
SER CA   C  N S 296 
SER C    C  N N 297 
SER O    O  N N 298 
SER CB   C  N N 299 
SER OG   O  N N 300 
SER OXT  O  N N 301 
SER H    H  N N 302 
SER H2   H  N N 303 
SER HA   H  N N 304 
SER HB2  H  N N 305 
SER HB3  H  N N 306 
SER HG   H  N N 307 
SER HXT  H  N N 308 
THR N    N  N N 309 
THR CA   C  N S 310 
THR C    C  N N 311 
THR O    O  N N 312 
THR CB   C  N R 313 
THR OG1  O  N N 314 
THR CG2  C  N N 315 
THR OXT  O  N N 316 
THR H    H  N N 317 
THR H2   H  N N 318 
THR HA   H  N N 319 
THR HB   H  N N 320 
THR HG1  H  N N 321 
THR HG21 H  N N 322 
THR HG22 H  N N 323 
THR HG23 H  N N 324 
THR HXT  H  N N 325 
TRP N    N  N N 326 
TRP CA   C  N S 327 
TRP C    C  N N 328 
TRP O    O  N N 329 
TRP CB   C  N N 330 
TRP CG   C  Y N 331 
TRP CD1  C  Y N 332 
TRP CD2  C  Y N 333 
TRP NE1  N  Y N 334 
TRP CE2  C  Y N 335 
TRP CE3  C  Y N 336 
TRP CZ2  C  Y N 337 
TRP CZ3  C  Y N 338 
TRP CH2  C  Y N 339 
TRP OXT  O  N N 340 
TRP H    H  N N 341 
TRP H2   H  N N 342 
TRP HA   H  N N 343 
TRP HB2  H  N N 344 
TRP HB3  H  N N 345 
TRP HD1  H  N N 346 
TRP HE1  H  N N 347 
TRP HE3  H  N N 348 
TRP HZ2  H  N N 349 
TRP HZ3  H  N N 350 
TRP HH2  H  N N 351 
TRP HXT  H  N N 352 
TYR N    N  N N 353 
TYR CA   C  N S 354 
TYR C    C  N N 355 
TYR O    O  N N 356 
TYR CB   C  N N 357 
TYR CG   C  Y N 358 
TYR CD1  C  Y N 359 
TYR CD2  C  Y N 360 
TYR CE1  C  Y N 361 
TYR CE2  C  Y N 362 
TYR CZ   C  Y N 363 
TYR OH   O  N N 364 
TYR OXT  O  N N 365 
TYR H    H  N N 366 
TYR H2   H  N N 367 
TYR HA   H  N N 368 
TYR HB2  H  N N 369 
TYR HB3  H  N N 370 
TYR HD1  H  N N 371 
TYR HD2  H  N N 372 
TYR HE1  H  N N 373 
TYR HE2  H  N N 374 
TYR HH   H  N N 375 
TYR HXT  H  N N 376 
VAL N    N  N N 377 
VAL CA   C  N S 378 
VAL C    C  N N 379 
VAL O    O  N N 380 
VAL CB   C  N N 381 
VAL CG1  C  N N 382 
VAL CG2  C  N N 383 
VAL OXT  O  N N 384 
VAL H    H  N N 385 
VAL H2   H  N N 386 
VAL HA   H  N N 387 
VAL HB   H  N N 388 
VAL HG11 H  N N 389 
VAL HG12 H  N N 390 
VAL HG13 H  N N 391 
VAL HG21 H  N N 392 
VAL HG22 H  N N 393 
VAL HG23 H  N N 394 
VAL HXT  H  N N 395 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NO3 N   O1   doub N N 237 
NO3 N   O2   sing N N 238 
NO3 N   O3   sing N N 239 
PHE N   CA   sing N N 240 
PHE N   H    sing N N 241 
PHE N   H2   sing N N 242 
PHE CA  C    sing N N 243 
PHE CA  CB   sing N N 244 
PHE CA  HA   sing N N 245 
PHE C   O    doub N N 246 
PHE C   OXT  sing N N 247 
PHE CB  CG   sing N N 248 
PHE CB  HB2  sing N N 249 
PHE CB  HB3  sing N N 250 
PHE CG  CD1  doub Y N 251 
PHE CG  CD2  sing Y N 252 
PHE CD1 CE1  sing Y N 253 
PHE CD1 HD1  sing N N 254 
PHE CD2 CE2  doub Y N 255 
PHE CD2 HD2  sing N N 256 
PHE CE1 CZ   doub Y N 257 
PHE CE1 HE1  sing N N 258 
PHE CE2 CZ   sing Y N 259 
PHE CE2 HE2  sing N N 260 
PHE CZ  HZ   sing N N 261 
PHE OXT HXT  sing N N 262 
PRO N   CA   sing N N 263 
PRO N   CD   sing N N 264 
PRO N   H    sing N N 265 
PRO CA  C    sing N N 266 
PRO CA  CB   sing N N 267 
PRO CA  HA   sing N N 268 
PRO C   O    doub N N 269 
PRO C   OXT  sing N N 270 
PRO CB  CG   sing N N 271 
PRO CB  HB2  sing N N 272 
PRO CB  HB3  sing N N 273 
PRO CG  CD   sing N N 274 
PRO CG  HG2  sing N N 275 
PRO CG  HG3  sing N N 276 
PRO CD  HD2  sing N N 277 
PRO CD  HD3  sing N N 278 
PRO OXT HXT  sing N N 279 
SER N   CA   sing N N 280 
SER N   H    sing N N 281 
SER N   H2   sing N N 282 
SER CA  C    sing N N 283 
SER CA  CB   sing N N 284 
SER CA  HA   sing N N 285 
SER C   O    doub N N 286 
SER C   OXT  sing N N 287 
SER CB  OG   sing N N 288 
SER CB  HB2  sing N N 289 
SER CB  HB3  sing N N 290 
SER OG  HG   sing N N 291 
SER OXT HXT  sing N N 292 
THR N   CA   sing N N 293 
THR N   H    sing N N 294 
THR N   H2   sing N N 295 
THR CA  C    sing N N 296 
THR CA  CB   sing N N 297 
THR CA  HA   sing N N 298 
THR C   O    doub N N 299 
THR C   OXT  sing N N 300 
THR CB  OG1  sing N N 301 
THR CB  CG2  sing N N 302 
THR CB  HB   sing N N 303 
THR OG1 HG1  sing N N 304 
THR CG2 HG21 sing N N 305 
THR CG2 HG22 sing N N 306 
THR CG2 HG23 sing N N 307 
THR OXT HXT  sing N N 308 
TRP N   CA   sing N N 309 
TRP N   H    sing N N 310 
TRP N   H2   sing N N 311 
TRP CA  C    sing N N 312 
TRP CA  CB   sing N N 313 
TRP CA  HA   sing N N 314 
TRP C   O    doub N N 315 
TRP C   OXT  sing N N 316 
TRP CB  CG   sing N N 317 
TRP CB  HB2  sing N N 318 
TRP CB  HB3  sing N N 319 
TRP CG  CD1  doub Y N 320 
TRP CG  CD2  sing Y N 321 
TRP CD1 NE1  sing Y N 322 
TRP CD1 HD1  sing N N 323 
TRP CD2 CE2  doub Y N 324 
TRP CD2 CE3  sing Y N 325 
TRP NE1 CE2  sing Y N 326 
TRP NE1 HE1  sing N N 327 
TRP CE2 CZ2  sing Y N 328 
TRP CE3 CZ3  doub Y N 329 
TRP CE3 HE3  sing N N 330 
TRP CZ2 CH2  doub Y N 331 
TRP CZ2 HZ2  sing N N 332 
TRP CZ3 CH2  sing Y N 333 
TRP CZ3 HZ3  sing N N 334 
TRP CH2 HH2  sing N N 335 
TRP OXT HXT  sing N N 336 
TYR N   CA   sing N N 337 
TYR N   H    sing N N 338 
TYR N   H2   sing N N 339 
TYR CA  C    sing N N 340 
TYR CA  CB   sing N N 341 
TYR CA  HA   sing N N 342 
TYR C   O    doub N N 343 
TYR C   OXT  sing N N 344 
TYR CB  CG   sing N N 345 
TYR CB  HB2  sing N N 346 
TYR CB  HB3  sing N N 347 
TYR CG  CD1  doub Y N 348 
TYR CG  CD2  sing Y N 349 
TYR CD1 CE1  sing Y N 350 
TYR CD1 HD1  sing N N 351 
TYR CD2 CE2  doub Y N 352 
TYR CD2 HD2  sing N N 353 
TYR CE1 CZ   doub Y N 354 
TYR CE1 HE1  sing N N 355 
TYR CE2 CZ   sing Y N 356 
TYR CE2 HE2  sing N N 357 
TYR CZ  OH   sing N N 358 
TYR OH  HH   sing N N 359 
TYR OXT HXT  sing N N 360 
VAL N   CA   sing N N 361 
VAL N   H    sing N N 362 
VAL N   H2   sing N N 363 
VAL CA  C    sing N N 364 
VAL CA  CB   sing N N 365 
VAL CA  HA   sing N N 366 
VAL C   O    doub N N 367 
VAL C   OXT  sing N N 368 
VAL CB  CG1  sing N N 369 
VAL CB  CG2  sing N N 370 
VAL CB  HB   sing N N 371 
VAL CG1 HG11 sing N N 372 
VAL CG1 HG12 sing N N 373 
VAL CG1 HG13 sing N N 374 
VAL CG2 HG21 sing N N 375 
VAL CG2 HG22 sing N N 376 
VAL CG2 HG23 sing N N 377 
VAL OXT HXT  sing N N 378 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5KXU 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   'small foils' 
_pdbx_serial_crystallography_sample_delivery.method        'fixed target' 
# 
_space_group.name_H-M_alt     'P 41 21 2' 
_space_group.name_Hall        'P 4abw 2nw' 
_space_group.IT_number        92 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FTX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014552 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014552 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009177 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? ?       ?       ? ? ?        ?        ? ? ?   ? ? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 1   ? 11.65138 -10.51351 17.71143  1.000 20.92332 ? 1   ALA A N   1 
ATOM   2    C  CA  . ALA A 1 1   ? 11.91041 -9.38304  16.82682  1.000 22.38512 ? 1   ALA A CA  1 
ATOM   3    C  C   . ALA A 1 1   ? 10.83056 -9.27190  15.75495  1.000 20.20364 ? 1   ALA A C   1 
ATOM   4    O  O   . ALA A 1 1   ? 10.09627 -10.22593 15.49380  1.000 20.02568 ? 1   ALA A O   1 
ATOM   5    C  CB  . ALA A 1 1   ? 13.28423 -9.51189  16.18768  1.000 21.11708 ? 1   ALA A CB  1 
ATOM   6    N  N   . ALA A 1 2   ? 10.74157 -8.09904  15.13318  1.000 18.30522 ? 2   ALA A N   1 
ATOM   7    C  CA  . ALA A 1 2   ? 9.74479  -7.85476  14.10075  1.000 20.96663 ? 2   ALA A CA  1 
ATOM   8    C  C   . ALA A 1 2   ? 10.29944 -6.85943  13.09435  1.000 24.06235 ? 2   ALA A C   1 
ATOM   9    O  O   . ALA A 1 2   ? 10.74767 -5.77340  13.47431  1.000 26.43441 ? 2   ALA A O   1 
ATOM   10   C  CB  . ALA A 1 2   ? 8.43804  -7.33073  14.70746  1.000 23.22681 ? 2   ALA A CB  1 
ATOM   11   N  N   . GLN A 1 3   ? 10.27411 -7.23838  11.81909  1.000 18.27475 ? 3   GLN A N   1 
ATOM   12   C  CA  . GLN A 1 3   ? 10.67008 -6.36690  10.71859  1.000 19.93771 ? 3   GLN A CA  1 
ATOM   13   C  C   . GLN A 1 3   ? 9.40636  -5.91243  9.99773   1.000 19.74134 ? 3   GLN A C   1 
ATOM   14   O  O   . GLN A 1 3   ? 8.75966  -6.70625  9.30567   1.000 18.98284 ? 3   GLN A O   1 
ATOM   15   C  CB  . GLN A 1 3   ? 11.62036 -7.08569  9.76379   1.000 15.27608 ? 3   GLN A CB  1 
ATOM   16   C  CG  . GLN A 1 3   ? 11.98666 -6.27106  8.53533   1.000 17.06838 ? 3   GLN A CG  1 
ATOM   17   C  CD  . GLN A 1 3   ? 12.77676 -7.06804  7.51769   1.000 21.37855 ? 3   GLN A CD  1 
ATOM   18   O  OE1 . GLN A 1 3   ? 13.06690 -8.24752  7.72001   1.000 22.86416 ? 3   GLN A OE1 1 
ATOM   19   N  NE2 . GLN A 1 3   ? 13.12715 -6.42512  6.41168   1.000 23.73223 ? 3   GLN A NE2 1 
ATOM   20   N  N   . THR A 1 4   ? 9.05760  -4.64026  10.16002  1.000 18.41881 ? 4   THR A N   1 
ATOM   21   C  CA  . THR A 1 4   ? 7.87352  -4.09376  9.51695   1.000 18.75219 ? 4   THR A CA  1 
ATOM   22   C  C   . THR A 1 4   ? 8.15563  -3.77362  8.05353   1.000 14.87506 ? 4   THR A C   1 
ATOM   23   O  O   . THR A 1 4   ? 9.28926  -3.47134  7.66688   1.000 16.73653 ? 4   THR A O   1 
ATOM   24   C  CB  . THR A 1 4   ? 7.39868  -2.83423  10.24121  1.000 23.15471 ? 4   THR A CB  1 
ATOM   25   O  OG1 . THR A 1 4   ? 8.45036  -1.86062  10.24386  1.000 19.13479 ? 4   THR A OG1 1 
ATOM   26   C  CG2 . THR A 1 4   ? 7.00944  -3.16284  11.67760  1.000 24.37377 ? 4   THR A CG2 1 
ATOM   27   N  N   . ASN A 1 5   ? 7.10054  -3.84043  7.24091   1.000 20.17301 ? 5   ASN A N   1 
ATOM   28   C  CA  . ASN A 1 5   ? 7.18630  -3.59615  5.80107   1.000 25.31877 ? 5   ASN A CA  1 
ATOM   29   C  C   . ASN A 1 5   ? 8.26099  -4.47303  5.16234   1.000 27.26359 ? 5   ASN A C   1 
ATOM   30   O  O   . ASN A 1 5   ? 9.08221  -4.02123  4.36067   1.000 20.24410 ? 5   ASN A O   1 
ATOM   31   C  CB  . ASN A 1 5   ? 7.43406  -2.11581  5.51216   1.000 26.87541 ? 5   ASN A CB  1 
ATOM   32   C  CG  . ASN A 1 5   ? 6.23068  -1.25381  5.83434   1.000 36.23936 ? 5   ASN A CG  1 
ATOM   33   O  OD1 . ASN A 1 5   ? 5.11478  -1.54337  5.40290   1.000 41.02482 ? 5   ASN A OD1 1 
ATOM   34   N  ND2 . ASN A 1 5   ? 6.44775  -0.19458  6.60492   1.000 31.87135 ? 5   ASN A ND2 1 
ATOM   35   N  N   . ALA A 1 6   ? 8.25199  -5.74472  5.53926   1.000 20.54546 ? 6   ALA A N   1 
ATOM   36   C  CA  . ALA A 1 6   ? 9.22662  -6.69729  5.04573   1.000 17.81308 ? 6   ALA A CA  1 
ATOM   37   C  C   . ALA A 1 6   ? 8.81906  -7.21058  3.66806   1.000 13.69813 ? 6   ALA A C   1 
ATOM   38   O  O   . ALA A 1 6   ? 7.66711  -7.05306  3.25388   1.000 14.53186 ? 6   ALA A O   1 
ATOM   39   C  CB  . ALA A 1 6   ? 9.36061  -7.85739  6.02784   1.000 15.42732 ? 6   ALA A CB  1 
ATOM   40   N  N   . PRO A 1 7   ? 9.75715  -7.79321  2.91824   1.000 12.48946 ? 7   PRO A N   1 
ATOM   41   C  CA  . PRO A 1 7   ? 9.37620  -8.51423  1.69684   1.000 16.48300 ? 7   PRO A CA  1 
ATOM   42   C  C   . PRO A 1 7   ? 8.32573  -9.57152  2.00823   1.000 14.63695 ? 7   PRO A C   1 
ATOM   43   O  O   . PRO A 1 7   ? 8.35458  -10.19934 3.06790   1.000 13.36497 ? 7   PRO A O   1 
ATOM   44   C  CB  . PRO A 1 7   ? 10.69510 -9.13849  1.23249   1.000 14.24189 ? 7   PRO A CB  1 
ATOM   45   C  CG  . PRO A 1 7   ? 11.74109 -8.19416  1.74348   1.000 14.87654 ? 7   PRO A CG  1 
ATOM   46   C  CD  . PRO A 1 7   ? 11.22156 -7.68606  3.06441   1.000 16.01722 ? 7   PRO A CD  1 
ATOM   47   N  N   . TRP A 1 8   ? 7.37903  -9.75817  1.08160   1.000 11.38893 ? 8   TRP A N   1 
ATOM   48   C  CA  . TRP A 1 8   ? 6.23329  -10.61375 1.37929   1.000 15.04820 ? 8   TRP A CA  1 
ATOM   49   C  C   . TRP A 1 8   ? 6.66299  -12.04060 1.69373   1.000 15.20601 ? 8   TRP A C   1 
ATOM   50   O  O   . TRP A 1 8   ? 6.00008  -12.72739 2.47929   1.000 12.97493 ? 8   TRP A O   1 
ATOM   51   C  CB  . TRP A 1 8   ? 5.23631  -10.59917 0.21725   1.000 12.73957 ? 8   TRP A CB  1 
ATOM   52   C  CG  . TRP A 1 8   ? 5.63492  -11.45700 -0.94274  1.000 17.54013 ? 8   TRP A CG  1 
ATOM   53   C  CD1 . TRP A 1 8   ? 6.27932  -11.05601 -2.07712  1.000 17.27387 ? 8   TRP A CD1 1 
ATOM   54   C  CD2 . TRP A 1 8   ? 5.40415  -12.86468 -1.08829  1.000 11.98536 ? 8   TRP A CD2 1 
ATOM   55   N  NE1 . TRP A 1 8   ? 6.46981  -12.12694 -2.91560  1.000 16.66083 ? 8   TRP A NE1 1 
ATOM   56   C  CE2 . TRP A 1 8   ? 5.94012  -13.24810 -2.33243  1.000 17.32131 ? 8   TRP A CE2 1 
ATOM   57   C  CE3 . TRP A 1 8   ? 4.79978  -13.83820 -0.28453  1.000 14.85984 ? 8   TRP A CE3 1 
ATOM   58   C  CZ2 . TRP A 1 8   ? 5.88901  -14.56086 -2.79310  1.000 14.57054 ? 8   TRP A CZ2 1 
ATOM   59   C  CZ3 . TRP A 1 8   ? 4.75316  -15.14119 -0.74241  1.000 12.95096 ? 8   TRP A CZ3 1 
ATOM   60   C  CH2 . TRP A 1 8   ? 5.29432  -15.49027 -1.98484  1.000 15.24337 ? 8   TRP A CH2 1 
ATOM   61   N  N   . GLY A 1 9   ? 7.76208  -12.50276 1.09381   1.000 13.70798 ? 9   GLY A N   1 
ATOM   62   C  CA  . GLY A 1 9   ? 8.22980  -13.85132 1.36800   1.000 13.84830 ? 9   GLY A CA  1 
ATOM   63   C  C   . GLY A 1 9   ? 8.63364  -14.04829 2.81613   1.000 15.15882 ? 9   GLY A C   1 
ATOM   64   O  O   . GLY A 1 9   ? 8.31975  -15.07460 3.42394   1.000 11.28738 ? 9   GLY A O   1 
ATOM   65   N  N   . LEU A 1 10  ? 9.33568  -13.06819 3.38923   1.000 11.07981 ? 10  LEU A N   1 
ATOM   66   C  CA  . LEU A 1 10  ? 9.72953  -13.16785 4.79075   1.000 13.59987 ? 10  LEU A CA  1 
ATOM   67   C  C   . LEU A 1 10  ? 8.51318  -13.14761 5.70691   1.000 14.20798 ? 10  LEU A C   1 
ATOM   68   O  O   . LEU A 1 10  ? 8.44575  -13.91124 6.67697   1.000 13.18078 ? 10  LEU A O   1 
ATOM   69   C  CB  . LEU A 1 10  ? 10.68868 -12.03405 5.15052   1.000 10.86987 ? 10  LEU A CB  1 
ATOM   70   C  CG  . LEU A 1 10  ? 11.99733 -11.98583 4.36319   1.000 16.78884 ? 10  LEU A CG  1 
ATOM   71   C  CD1 . LEU A 1 10  ? 12.89511 -10.88245 4.89952   1.000 16.51003 ? 10  LEU A CD1 1 
ATOM   72   C  CD2 . LEU A 1 10  ? 12.70060 -13.32958 4.41405   1.000 13.90169 ? 10  LEU A CD2 1 
ATOM   73   N  N   . ALA A 1 11  ? 7.54014  -12.28242 5.41454   1.000 13.17044 ? 11  ALA A N   1 
ATOM   74   C  CA  . ALA A 1 11  ? 6.33748  -12.22355 6.23844   1.000 13.73667 ? 11  ALA A CA  1 
ATOM   75   C  C   . ALA A 1 11  ? 5.53124  -13.51224 6.13267   1.000 17.37722 ? 11  ALA A C   1 
ATOM   76   O  O   . ALA A 1 11  ? 4.91273  -13.94950 7.11080   1.000 18.76896 ? 11  ALA A O   1 
ATOM   77   C  CB  . ALA A 1 11  ? 5.48343  -11.02158 5.83586   1.000 14.61090 ? 11  ALA A CB  1 
ATOM   78   N  N   . ARG A 1 12  ? 5.53685  -14.14056 4.95441   1.000 12.20331 ? 12  ARG A N   1 
ATOM   79   C  CA  . ARG A 1 12  ? 4.73102  -15.33926 4.74653   1.000 16.14123 ? 12  ARG A CA  1 
ATOM   80   C  C   . ARG A 1 12  ? 5.21657  -16.49480 5.61286   1.000 17.49511 ? 12  ARG A C   1 
ATOM   81   O  O   . ARG A 1 12  ? 4.40586  -17.24534 6.16816   1.000 19.87845 ? 12  ARG A O   1 
ATOM   82   C  CB  . ARG A 1 12  ? 4.74999  -15.73280 3.26868   1.000 14.72382 ? 12  ARG A CB  1 
ATOM   83   C  CG  . ARG A 1 12  ? 3.76165  -16.82926 2.90764   1.000 19.00866 ? 12  ARG A CG  1 
ATOM   84   C  CD  . ARG A 1 12  ? 2.33417  -16.35572 3.11878   1.000 16.81195 ? 12  ARG A CD  1 
ATOM   85   N  NE  . ARG A 1 12  ? 1.37899  -17.45570 3.08187   1.000 13.74219 ? 12  ARG A NE  1 
ATOM   86   C  CZ  . ARG A 1 12  ? 1.06997  -18.20750 4.12894   1.000 17.20768 ? 12  ARG A CZ  1 
ATOM   87   N  NH1 . ARG A 1 12  ? 1.64038  -18.01732 5.30729   1.000 16.01377 ? 12  ARG A NH1 1 
ATOM   88   N  NH2 . ARG A 1 12  ? 0.16783  -19.17475 3.99026   1.000 13.95982 ? 12  ARG A NH2 1 
ATOM   89   N  N   . ILE A 1 13  ? 6.53723  -16.65418 5.74594   1.000 14.11087 ? 13  ILE A N   1 
ATOM   90   C  CA  . ILE A 1 13  ? 7.07729  -17.78114 6.50550   1.000 20.21267 ? 13  ILE A CA  1 
ATOM   91   C  C   . ILE A 1 13  ? 6.96177  -17.59256 8.00838   1.000 20.09520 ? 13  ILE A C   1 
ATOM   92   O  O   . ILE A 1 13  ? 7.24084  -18.53321 8.76186   1.000 18.49627 ? 13  ILE A O   1 
ATOM   93   C  CB  . ILE A 1 13  ? 8.55259  -18.04638 6.15056   1.000 17.28955 ? 13  ILE A CB  1 
ATOM   94   C  CG1 . ILE A 1 13  ? 9.45283  -16.96417 6.74820   1.000 23.16974 ? 13  ILE A CG1 1 
ATOM   95   C  CG2 . ILE A 1 13  ? 8.73325  -18.12010 4.64096   1.000 16.80505 ? 13  ILE A CG2 1 
ATOM   96   C  CD1 . ILE A 1 13  ? 10.93164 -17.24190 6.58527   1.000 21.54883 ? 13  ILE A CD1 1 
ATOM   97   N  N   . SER A 1 14  ? 6.56386  -16.40620 8.46871   1.000 18.22830 ? 14  SER A N   1 
ATOM   98   C  CA  . SER A 1 14  ? 6.32491  -16.15218 9.88345   1.000 18.37433 ? 14  SER A CA  1 
ATOM   99   C  C   . SER A 1 14  ? 4.84241  -15.96519 10.18835  1.000 19.88794 ? 14  SER A C   1 
ATOM   100  O  O   . SER A 1 14  ? 4.48960  -15.42001 11.23936  1.000 18.13399 ? 14  SER A O   1 
ATOM   101  C  CB  . SER A 1 14  ? 7.12155  -14.93239 10.34535  1.000 15.29523 ? 14  SER A CB  1 
ATOM   102  O  OG  . SER A 1 14  ? 6.70113  -13.76247 9.66739   1.000 12.20474 ? 14  SER A OG  1 
ATOM   103  N  N   . SER A 1 15  ? 3.96889  -16.40932 9.28801   1.000 19.95767 ? 15  SER A N   1 
ATOM   104  C  CA  . SER A 1 15  ? 2.53212  -16.27271 9.45867   1.000 22.27803 ? 15  SER A CA  1 
ATOM   105  C  C   . SER A 1 15  ? 1.84250  -17.54626 8.99511   1.000 22.40103 ? 15  SER A C   1 
ATOM   106  O  O   . SER A 1 15  ? 2.35300  -18.27102 8.13711   1.000 19.91582 ? 15  SER A O   1 
ATOM   107  C  CB  . SER A 1 15  ? 1.98382  -15.07307 8.67692   1.000 18.70671 ? 15  SER A CB  1 
ATOM   108  O  OG  . SER A 1 15  ? 0.56976  -15.02550 8.75008   1.000 23.81916 ? 15  SER A OG  1 
ATOM   109  N  N   . THR A 1 16  ? 0.67462  -17.81278 9.57717   1.000 23.90449 ? 16  THR A N   1 
ATOM   110  C  CA  . THR A 1 16  ? -0.15878 -18.93094 9.15973   1.000 19.95953 ? 16  THR A CA  1 
ATOM   111  C  C   . THR A 1 16  ? -1.09194 -18.57226 8.01228   1.000 23.05476 ? 16  THR A C   1 
ATOM   112  O  O   . THR A 1 16  ? -1.67031 -19.47472 7.39773   1.000 24.91632 ? 16  THR A O   1 
ATOM   113  C  CB  . THR A 1 16  ? -0.98636 -19.44517 10.34098  1.000 23.42326 ? 16  THR A CB  1 
ATOM   114  O  OG1 . THR A 1 16  ? -1.72747 -18.35964 10.91125  1.000 19.00898 ? 16  THR A OG1 1 
ATOM   115  C  CG2 . THR A 1 16  ? -0.08026 -20.04648 11.40185  1.000 20.21380 ? 16  THR A CG2 1 
ATOM   116  N  N   . SER A 1 17  ? -1.24806 -17.28780 7.71020   1.000 21.96643 ? 17  SER A N   1 
ATOM   117  C  CA  . SER A 1 17  ? -2.12839 -16.81992 6.65471   1.000 21.70704 ? 17  SER A CA  1 
ATOM   118  C  C   . SER A 1 17  ? -1.38650 -15.84114 5.75782   1.000 19.25738 ? 17  SER A C   1 
ATOM   119  O  O   . SER A 1 17  ? -0.47515 -15.14242 6.21269   1.000 17.40396 ? 17  SER A O   1 
ATOM   120  C  CB  . SER A 1 17  ? -3.37738 -16.14046 7.23740   1.000 18.99362 ? 17  SER A CB  1 
ATOM   121  O  OG  . SER A 1 17  ? -3.06019 -14.88107 7.80458   1.000 30.51927 ? 17  SER A OG  1 
ATOM   122  N  N   . PRO A 1 18  ? -1.75021 -15.77440 4.48134   1.000 21.51663 ? 18  PRO A N   1 
ATOM   123  C  CA  . PRO A 1 18  ? -1.10369 -14.82749 3.56936   1.000 18.72208 ? 18  PRO A CA  1 
ATOM   124  C  C   . PRO A 1 18  ? -1.62274 -13.41076 3.78333   1.000 18.67287 ? 18  PRO A C   1 
ATOM   125  O  O   . PRO A 1 18  ? -2.64898 -13.17987 4.42229   1.000 19.92774 ? 18  PRO A O   1 
ATOM   126  C  CB  . PRO A 1 18  ? -1.49546 -15.35636 2.18794   1.000 17.94450 ? 18  PRO A CB  1 
ATOM   127  C  CG  . PRO A 1 18  ? -2.82585 -16.00359 2.41464   1.000 22.14419 ? 18  PRO A CG  1 
ATOM   128  C  CD  . PRO A 1 18  ? -2.74676 -16.61499 3.79125   1.000 19.38391 ? 18  PRO A CD  1 
ATOM   129  N  N   . GLY A 1 19  ? -0.87888 -12.45242 3.23568   1.000 21.99543 ? 19  GLY A N   1 
ATOM   130  C  CA  . GLY A 1 19  ? -1.30117 -11.06911 3.21674   1.000 25.22831 ? 19  GLY A CA  1 
ATOM   131  C  C   . GLY A 1 19  ? -0.70956 -10.17800 4.28744   1.000 26.37516 ? 19  GLY A C   1 
ATOM   132  O  O   . GLY A 1 19  ? -1.04236 -8.98694  4.32355   1.000 22.36359 ? 19  GLY A O   1 
ATOM   133  N  N   . THR A 1 20  ? 0.14578  -10.70346 5.15841   1.000 27.68539 ? 20  THR A N   1 
ATOM   134  C  CA  . THR A 1 20  ? 0.76732  -9.88606  6.18870   1.000 26.56796 ? 20  THR A CA  1 
ATOM   135  C  C   . THR A 1 20  ? 2.05602  -9.25370  5.66454   1.000 28.58012 ? 20  THR A C   1 
ATOM   136  O  O   . THR A 1 20  ? 2.58874  -9.63503  4.62050   1.000 26.96934 ? 20  THR A O   1 
ATOM   137  C  CB  . THR A 1 20  ? 1.04527  -10.71575 7.44161   1.000 23.04834 ? 20  THR A CB  1 
ATOM   138  O  OG1 . THR A 1 20  ? 1.99511  -11.74444 7.13613   1.000 21.48618 ? 20  THR A OG1 1 
ATOM   139  C  CG2 . THR A 1 20  ? -0.24161 -11.35033 7.95144   1.000 23.68050 ? 20  THR A CG2 1 
ATOM   140  N  N   . SER A 1 21  ? 2.55911  -8.26519  6.40958   1.000 27.07584 ? 21  SER A N   1 
ATOM   141  C  CA  . SER A 1 21  ? 3.72428  -7.50039  5.98161   1.000 31.54170 ? 21  SER A CA  1 
ATOM   142  C  C   . SER A 1 21  ? 4.81592  -7.42054  7.04419   1.000 22.64262 ? 21  SER A C   1 
ATOM   143  O  O   . SER A 1 21  ? 5.78855  -6.67887  6.85740   1.000 25.43313 ? 21  SER A O   1 
ATOM   144  C  CB  . SER A 1 21  ? 3.30886  -6.08406  5.56388   1.000 28.59966 ? 21  SER A CB  1 
ATOM   145  O  OG  . SER A 1 21  ? 2.70815  -5.39037  6.64350   1.000 35.96925 ? 21  SER A OG  1 
ATOM   146  N  N   . THR A 1 22  ? 4.69186  -8.15970  8.14278   1.000 19.78840 ? 22  THR A N   1 
ATOM   147  C  CA  . THR A 1 22  ? 5.67000  -8.13935  9.22225   1.000 19.99303 ? 22  THR A CA  1 
ATOM   148  C  C   . THR A 1 22  ? 6.35314  -9.49448  9.32484   1.000 16.90696 ? 22  THR A C   1 
ATOM   149  O  O   . THR A 1 22  ? 5.68199  -10.53242 9.35418   1.000 20.52143 ? 22  THR A O   1 
ATOM   150  C  CB  . THR A 1 22  ? 5.00965  -7.78663  10.55639  1.000 20.30272 ? 22  THR A CB  1 
ATOM   151  O  OG1 . THR A 1 22  ? 4.40030  -6.49360  10.45991  1.000 27.07505 ? 22  THR A OG1 1 
ATOM   152  C  CG2 . THR A 1 22  ? 6.04262  -7.77214  11.67543  1.000 18.15984 ? 22  THR A CG2 1 
ATOM   153  N  N   . TYR A 1 23  ? 7.68246  -9.48029  9.38328   1.000 10.15123 ? 23  TYR A N   1 
ATOM   154  C  CA  . TYR A 1 23  ? 8.46351  -10.69756 9.56180   1.000 15.01358 ? 23  TYR A CA  1 
ATOM   155  C  C   . TYR A 1 23  ? 8.79772  -10.84416 11.04144  1.000 14.90711 ? 23  TYR A C   1 
ATOM   156  O  O   . TYR A 1 23  ? 9.56134  -10.04766 11.59487  1.000 14.98916 ? 23  TYR A O   1 
ATOM   157  C  CB  . TYR A 1 23  ? 9.72248  -10.65696 8.70064   1.000 12.83390 ? 23  TYR A CB  1 
ATOM   158  C  CG  . TYR A 1 23  ? 10.66409 -11.82102 8.91860   1.000 10.34651 ? 23  TYR A CG  1 
ATOM   159  C  CD1 . TYR A 1 23  ? 10.18080 -13.11243 9.10203   1.000 14.32355 ? 23  TYR A CD1 1 
ATOM   160  C  CD2 . TYR A 1 23  ? 12.03951 -11.62969 8.92536   1.000 12.22897 ? 23  TYR A CD2 1 
ATOM   161  C  CE1 . TYR A 1 23  ? 11.04434 -14.17952 9.29712   1.000 13.90792 ? 23  TYR A CE1 1 
ATOM   162  C  CE2 . TYR A 1 23  ? 12.90958 -12.68713 9.11680   1.000 15.31725 ? 23  TYR A CE2 1 
ATOM   163  C  CZ  . TYR A 1 23  ? 12.40825 -13.95917 9.30221   1.000 13.75018 ? 23  TYR A CZ  1 
ATOM   164  O  OH  . TYR A 1 23  ? 13.27064 -15.01508 9.49340   1.000 13.28342 ? 23  TYR A OH  1 
ATOM   165  N  N   . TYR A 1 24  ? 8.21536  -11.85438 11.68058  1.000 16.45528 ? 24  TYR A N   1 
ATOM   166  C  CA  . TYR A 1 24  ? 8.47080  -12.15979 13.08140  1.000 17.86513 ? 24  TYR A CA  1 
ATOM   167  C  C   . TYR A 1 24  ? 9.54170  -13.23954 13.16330  1.000 18.76909 ? 24  TYR A C   1 
ATOM   168  O  O   . TYR A 1 24  ? 9.42239  -14.28598 12.51771  1.000 18.13835 ? 24  TYR A O   1 
ATOM   169  C  CB  . TYR A 1 24  ? 7.19496  -12.62860 13.78562  1.000 19.47775 ? 24  TYR A CB  1 
ATOM   170  C  CG  . TYR A 1 24  ? 6.02621  -11.66814 13.69938  1.000 18.82668 ? 24  TYR A CG  1 
ATOM   171  C  CD1 . TYR A 1 24  ? 5.91544  -10.59494 14.57616  1.000 28.64485 ? 24  TYR A CD1 1 
ATOM   172  C  CD2 . TYR A 1 24  ? 5.02413  -11.84564 12.75310  1.000 27.17095 ? 24  TYR A CD2 1 
ATOM   173  C  CE1 . TYR A 1 24  ? 4.84512  -9.71843  14.50440  1.000 22.72458 ? 24  TYR A CE1 1 
ATOM   174  C  CE2 . TYR A 1 24  ? 3.94980  -10.97546 12.67492  1.000 25.68224 ? 24  TYR A CE2 1 
ATOM   175  C  CZ  . TYR A 1 24  ? 3.86506  -9.91553  13.55197  1.000 24.41334 ? 24  TYR A CZ  1 
ATOM   176  O  OH  . TYR A 1 24  ? 2.79974  -9.04681  13.47759  1.000 31.40923 ? 24  TYR A OH  1 
ATOM   177  N  N   . TYR A 1 25  ? 10.58364 -12.98682 13.95170  1.000 19.92525 ? 25  TYR A N   1 
ATOM   178  C  CA  . TYR A 1 25  ? 11.68917 -13.93005 14.04820  1.000 15.68410 ? 25  TYR A CA  1 
ATOM   179  C  C   . TYR A 1 25  ? 12.39125 -13.74535 15.38488  1.000 19.46433 ? 25  TYR A C   1 
ATOM   180  O  O   . TYR A 1 25  ? 12.27939 -12.69889 16.02868  1.000 22.65005 ? 25  TYR A O   1 
ATOM   181  C  CB  . TYR A 1 25  ? 12.67816 -13.75315 12.89004  1.000 18.77774 ? 25  TYR A CB  1 
ATOM   182  C  CG  . TYR A 1 25  ? 13.40886 -12.42777 12.90316  1.000 14.05240 ? 25  TYR A CG  1 
ATOM   183  C  CD1 . TYR A 1 25  ? 12.80543 -11.27405 12.41743  1.000 17.84266 ? 25  TYR A CD1 1 
ATOM   184  C  CD2 . TYR A 1 25  ? 14.70488 -12.33223 13.39515  1.000 15.69479 ? 25  TYR A CD2 1 
ATOM   185  C  CE1 . TYR A 1 25  ? 13.46936 -10.06212 12.42790  1.000 16.45314 ? 25  TYR A CE1 1 
ATOM   186  C  CE2 . TYR A 1 25  ? 15.37828 -11.12559 13.40692  1.000 17.38264 ? 25  TYR A CE2 1 
ATOM   187  C  CZ  . TYR A 1 25  ? 14.75644 -9.99383  12.92296  1.000 21.34006 ? 25  TYR A CZ  1 
ATOM   188  O  OH  . TYR A 1 25  ? 15.42392 -8.78964  12.93507  1.000 20.16675 ? 25  TYR A OH  1 
ATOM   189  N  N   . ASP A 1 26  ? 13.12164 -14.78055 15.79020  1.000 19.55203 ? 26  ASP A N   1 
ATOM   190  C  CA  . ASP A 1 26  ? 13.86443 -14.74313 17.04112  1.000 21.78764 ? 26  ASP A CA  1 
ATOM   191  C  C   . ASP A 1 26  ? 15.18276 -14.00663 16.84340  1.000 24.55865 ? 26  ASP A C   1 
ATOM   192  O  O   . ASP A 1 26  ? 15.80861 -14.09815 15.78380  1.000 18.17645 ? 26  ASP A O   1 
ATOM   193  C  CB  . ASP A 1 26  ? 14.11163 -16.16294 17.55428  1.000 19.88815 ? 26  ASP A CB  1 
ATOM   194  C  CG  . ASP A 1 26  ? 14.84312 -16.19081 18.88332  1.000 22.85366 ? 26  ASP A CG  1 
ATOM   195  O  OD1 . ASP A 1 26  ? 16.07357 -15.97260 18.90250  1.000 23.56468 ? 26  ASP A OD1 1 
ATOM   196  O  OD2 . ASP A 1 26  ? 14.18198 -16.43209 19.91398  1.000 23.85979 ? 26  ASP A OD2 1 
ATOM   197  N  N   . GLU A 1 27  ? 15.60633 -13.27969 17.88138  1.000 23.82478 ? 27  GLU A N   1 
ATOM   198  C  CA  . GLU A 1 27  ? 16.76253 -12.39560 17.76685  1.000 21.53126 ? 27  GLU A CA  1 
ATOM   199  C  C   . GLU A 1 27  ? 18.06169 -13.14387 17.49961  1.000 21.11762 ? 27  GLU A C   1 
ATOM   200  O  O   . GLU A 1 27  ? 19.02365 -12.53068 17.02309  1.000 18.58367 ? 27  GLU A O   1 
ATOM   201  C  CB  . GLU A 1 27  ? 16.91032 -11.55436 19.03690  1.000 23.74000 ? 27  GLU A CB  1 
ATOM   202  C  CG  . GLU A 1 27  ? 15.92912 -10.39479 19.14812  1.000 35.50735 ? 27  GLU A CG  1 
ATOM   203  C  CD  . GLU A 1 27  ? 14.51855 -10.83555 19.50278  1.000 41.34111 ? 27  GLU A CD  1 
ATOM   204  O  OE1 . GLU A 1 27  ? 13.60731 -9.98442  19.48926  1.000 41.48016 ? 27  GLU A OE1 1 
ATOM   205  O  OE2 . GLU A 1 27  ? 14.31697 -12.03089 19.80094  1.000 33.00342 ? 27  GLU A OE2 1 
ATOM   206  N  N   . SER A 1 28  ? 18.12146 -14.44277 17.80771  1.000 21.53327 ? 28  SER A N   1 
ATOM   207  C  CA  . SER A 1 28  ? 19.33101 -15.21055 17.52483  1.000 17.66036 ? 28  SER A CA  1 
ATOM   208  C  C   . SER A 1 28  ? 19.68233 -15.14715 16.04340  1.000 18.44542 ? 28  SER A C   1 
ATOM   209  O  O   . SER A 1 28  ? 20.85951 -15.03409 15.68081  1.000 18.81557 ? 28  SER A O   1 
ATOM   210  C  CB  . SER A 1 28  ? 19.15544 -16.65863 17.98540  1.000 17.16034 ? 28  SER A CB  1 
ATOM   211  O  OG  . SER A 1 28  ? 17.94056 -17.20565 17.50371  1.000 17.08852 ? 28  SER A OG  1 
ATOM   212  N  N   . ALA A 1 29  ? 18.67069 -15.22378 15.17574  1.000 14.15227 ? 29  ALA A N   1 
ATOM   213  C  CA  . ALA A 1 29  ? 18.80015 -14.89746 13.75443  1.000 15.14854 ? 29  ALA A CA  1 
ATOM   214  C  C   . ALA A 1 29  ? 19.87126 -15.73240 13.05568  1.000 14.57324 ? 29  ALA A C   1 
ATOM   215  O  O   . ALA A 1 29  ? 20.51044 -15.27482 12.10386  1.000 13.49544 ? 29  ALA A O   1 
ATOM   216  C  CB  . ALA A 1 29  ? 19.07254 -13.40355 13.56186  1.000 13.52196 ? 29  ALA A CB  1 
ATOM   217  N  N   . GLY A 1 30  ? 20.06945 -16.96564 13.51226  1.000 13.63763 ? 30  GLY A N   1 
ATOM   218  C  CA  . GLY A 1 30  ? 20.99746 -17.86550 12.85989  1.000 10.25063 ? 30  GLY A CA  1 
ATOM   219  C  C   . GLY A 1 30  ? 22.46210 -17.63099 13.15352  1.000 13.68547 ? 30  GLY A C   1 
ATOM   220  O  O   . GLY A 1 30  ? 23.31192 -18.13765 12.41092  1.000 12.73219 ? 30  GLY A O   1 
ATOM   221  N  N   . GLN A 1 31  ? 22.78998 -16.88191 14.20379  1.000 14.39275 ? 31  GLN A N   1 
ATOM   222  C  CA  . GLN A 1 31  ? 24.18647 -16.69371 14.57097  1.000 15.58346 ? 31  GLN A CA  1 
ATOM   223  C  C   . GLN A 1 31  ? 24.80331 -18.02203 14.98971  1.000 14.38894 ? 31  GLN A C   1 
ATOM   224  O  O   . GLN A 1 31  ? 24.16430 -18.84243 15.65265  1.000 15.31134 ? 31  GLN A O   1 
ATOM   225  C  CB  . GLN A 1 31  ? 24.30785 -15.67476 15.70352  1.000 15.80695 ? 31  GLN A CB  1 
ATOM   226  N  N   . GLY A 1 32  ? 26.05574 -18.23395 14.59474  1.000 12.25614 ? 32  GLY A N   1 
ATOM   227  C  CA  . GLY A 1 32  ? 26.73424 -19.48418 14.84715  1.000 16.97816 ? 32  GLY A CA  1 
ATOM   228  C  C   . GLY A 1 32  ? 26.56897 -20.53000 13.76557  1.000 13.71659 ? 32  GLY A C   1 
ATOM   229  O  O   . GLY A 1 32  ? 27.26231 -21.55424 13.80783  1.000 18.12373 ? 32  GLY A O   1 
ATOM   230  N  N   . SER A 1 33  ? 25.67624 -20.31215 12.80492  1.000 17.09688 ? 33  SER A N   1 
ATOM   231  C  CA  . SER A 1 33  ? 25.48153 -21.22029 11.68521  1.000 13.72630 ? 33  SER A CA  1 
ATOM   232  C  C   . SER A 1 33  ? 26.18521 -20.68338 10.44251  1.000 18.65331 ? 33  SER A C   1 
ATOM   233  O  O   . SER A 1 33  ? 26.55961 -19.51055 10.36701  1.000 12.82723 ? 33  SER A O   1 
ATOM   234  C  CB  . SER A 1 33  ? 23.98943 -21.42527 11.40270  1.000 13.05326 ? 33  SER A CB  1 
ATOM   235  O  OG  . SER A 1 33  ? 23.38436 -20.22744 10.94714  1.000 15.31878 ? 33  SER A OG  1 
ATOM   236  N  N   . CYS A 1 34  ? 26.36522 -21.56524 9.46241   1.000 13.98075 ? 34  CYS A N   1 
ATOM   237  C  CA  . CYS A 1 34  ? 27.04542 -21.23361 8.21869   1.000 12.53823 ? 34  CYS A CA  1 
ATOM   238  C  C   . CYS A 1 34  ? 26.24438 -21.78413 7.05003   1.000 13.07532 ? 34  CYS A C   1 
ATOM   239  O  O   . CYS A 1 34  ? 25.70190 -22.89025 7.12758   1.000 13.56519 ? 34  CYS A O   1 
ATOM   240  C  CB  . CYS A 1 34  ? 28.46695 -21.80570 8.19082   1.000 12.63803 ? 34  CYS A CB  1 
ATOM   241  S  SG  . CYS A 1 34  ? 29.54316 -21.23704 9.52529   1.000 17.07629 ? 34  CYS A SG  1 
ATOM   242  N  N   . VAL A 1 35  ? 26.16384 -21.00897 5.97108   1.000 9.98590  ? 35  VAL A N   1 
ATOM   243  C  CA  . VAL A 1 35  ? 25.41485 -21.39749 4.78129   1.000 10.38901 ? 35  VAL A CA  1 
ATOM   244  C  C   . VAL A 1 35  ? 26.30554 -21.19850 3.56453   1.000 15.14750 ? 35  VAL A C   1 
ATOM   245  O  O   . VAL A 1 35  ? 26.73216 -20.07224 3.28269   1.000 9.32370  ? 35  VAL A O   1 
ATOM   246  C  CB  . VAL A 1 35  ? 24.11326 -20.59502 4.62593   1.000 10.67150 ? 35  VAL A CB  1 
ATOM   247  C  CG1 . VAL A 1 35  ? 23.35951 -21.05309 3.38778   1.000 12.93596 ? 35  VAL A CG1 1 
ATOM   248  C  CG2 . VAL A 1 35  ? 23.25021 -20.73752 5.86636   1.000 9.32617  ? 35  VAL A CG2 1 
ATOM   249  N  N   . TYR A 1 36  ? 26.58158 -22.28517 2.84556   1.000 15.73024 ? 36  TYR A N   1 
ATOM   250  C  CA  . TYR A 1 36  ? 27.31822 -22.22417 1.58968   1.000 13.07711 ? 36  TYR A CA  1 
ATOM   251  C  C   . TYR A 1 36  ? 26.34564 -21.95546 0.44859   1.000 15.48779 ? 36  TYR A C   1 
ATOM   252  O  O   . TYR A 1 36  ? 25.35174 -22.67238 0.29205   1.000 11.40135 ? 36  TYR A O   1 
ATOM   253  C  CB  . TYR A 1 36  ? 28.07486 -23.52892 1.32920   1.000 10.28175 ? 36  TYR A CB  1 
ATOM   254  C  CG  . TYR A 1 36  ? 29.30200 -23.74376 2.18980   1.000 12.68509 ? 36  TYR A CG  1 
ATOM   255  C  CD1 . TYR A 1 36  ? 29.18803 -24.21303 3.49281   1.000 13.34857 ? 36  TYR A CD1 1 
ATOM   256  C  CD2 . TYR A 1 36  ? 30.57689 -23.49935 1.69075   1.000 13.32968 ? 36  TYR A CD2 1 
ATOM   257  C  CE1 . TYR A 1 36  ? 30.30898 -24.41851 4.28185   1.000 15.35475 ? 36  TYR A CE1 1 
ATOM   258  C  CE2 . TYR A 1 36  ? 31.70432 -23.70183 2.47159   1.000 15.38828 ? 36  TYR A CE2 1 
ATOM   259  C  CZ  . TYR A 1 36  ? 31.56489 -24.16105 3.76607   1.000 14.55532 ? 36  TYR A CZ  1 
ATOM   260  O  OH  . TYR A 1 36  ? 32.68414 -24.36393 4.54442   1.000 16.51259 ? 36  TYR A OH  1 
ATOM   261  N  N   . VAL A 1 37  ? 26.62980 -20.92549 -0.34249  1.000 10.74727 ? 37  VAL A N   1 
ATOM   262  C  CA  . VAL A 1 37  ? 25.82345 -20.58122 -1.50847  1.000 14.42667 ? 37  VAL A CA  1 
ATOM   263  C  C   . VAL A 1 37  ? 26.61480 -21.00054 -2.73790  1.000 13.04049 ? 37  VAL A C   1 
ATOM   264  O  O   . VAL A 1 37  ? 27.60936 -20.35915 -3.09859  1.000 13.18192 ? 37  VAL A O   1 
ATOM   265  C  CB  . VAL A 1 37  ? 25.46963 -19.08825 -1.55099  1.000 16.48704 ? 37  VAL A CB  1 
ATOM   266  C  CG1 . VAL A 1 37  ? 24.57858 -18.78759 -2.75094  1.000 14.56335 ? 37  VAL A CG1 1 
ATOM   267  C  CG2 . VAL A 1 37  ? 24.78017 -18.67052 -0.26548  1.000 19.57057 ? 37  VAL A CG2 1 
ATOM   268  N  N   . ILE A 1 38  ? 26.18005 -22.08337 -3.37255  1.000 10.04694 ? 38  ILE A N   1 
ATOM   269  C  CA  . ILE A 1 38  ? 26.86040 -22.66581 -4.52261  1.000 12.11860 ? 38  ILE A CA  1 
ATOM   270  C  C   . ILE A 1 38  ? 26.15231 -22.13596 -5.76424  1.000 13.15526 ? 38  ILE A C   1 
ATOM   271  O  O   . ILE A 1 38  ? 25.09406 -22.63816 -6.15538  1.000 12.89088 ? 38  ILE A O   1 
ATOM   272  C  CB  . ILE A 1 38  ? 26.85140 -24.19529 -4.46096  1.000 12.71797 ? 38  ILE A CB  1 
ATOM   273  C  CG1 . ILE A 1 38  ? 27.35541 -24.66827 -3.09514  1.000 11.23752 ? 38  ILE A CG1 1 
ATOM   274  C  CG2 . ILE A 1 38  ? 27.70671 -24.78593 -5.56835  1.000 12.10946 ? 38  ILE A CG2 1 
ATOM   275  C  CD1 . ILE A 1 38  ? 27.25888 -26.16413 -2.88874  1.000 20.72612 ? 38  ILE A CD1 1 
ATOM   276  N  N   . ASP A 1 39  ? 26.74270 -21.11901 -6.39394  1.000 13.77019 ? 39  ASP A N   1 
ATOM   277  C  CA  . ASP A 1 39  ? 26.05456 -20.38324 -7.44705  1.000 13.36841 ? 39  ASP A CA  1 
ATOM   278  C  C   . ASP A 1 39  ? 27.02835 -19.62744 -8.34566  1.000 12.29128 ? 39  ASP A C   1 
ATOM   279  O  O   . ASP A 1 39  ? 28.09264 -20.14618 -8.69896  1.000 12.55399 ? 39  ASP A O   1 
ATOM   280  C  CB  . ASP A 1 39  ? 25.05364 -19.41504 -6.81459  1.000 9.63168  ? 39  ASP A CB  1 
ATOM   281  C  CG  . ASP A 1 39  ? 23.83150 -19.19134 -7.67247  1.000 16.78082 ? 39  ASP A CG  1 
ATOM   282  O  OD1 . ASP A 1 39  ? 23.96200 -18.59115 -8.75944  1.000 15.49325 ? 39  ASP A OD1 1 
ATOM   283  O  OD2 . ASP A 1 39  ? 22.73475 -19.61882 -7.25514  1.000 17.20177 ? 39  ASP A OD2 1 
ATOM   284  N  N   . THR A 1 40  ? 26.66761 -18.40193 -8.72282  1.000 17.10583 ? 40  THR A N   1 
ATOM   285  C  CA  . THR A 1 40  ? 27.50993 -17.55511 -9.55705  1.000 15.18925 ? 40  THR A CA  1 
ATOM   286  C  C   . THR A 1 40  ? 28.49700 -16.72233 -8.74978  1.000 14.94055 ? 40  THR A C   1 
ATOM   287  O  O   . THR A 1 40  ? 29.27132 -15.96238 -9.34015  1.000 14.16858 ? 40  THR A O   1 
ATOM   288  C  CB  . THR A 1 40  ? 26.64418 -16.62157 -10.41370 1.000 13.35081 ? 40  THR A CB  1 
ATOM   289  O  OG1 . THR A 1 40  ? 25.87390 -15.76391 -9.56274  1.000 12.38894 ? 40  THR A OG1 1 
ATOM   290  C  CG2 . THR A 1 40  ? 25.70126 -17.42059 -11.30166 1.000 12.61576 ? 40  THR A CG2 1 
ATOM   291  N  N   . GLY A 1 41  ? 28.49410 -16.84932 -7.43020  1.000 12.07134 ? 41  GLY A N   1 
ATOM   292  C  CA  . GLY A 1 41  ? 29.31660 -16.03193 -6.56125  1.000 11.65871 ? 41  GLY A CA  1 
ATOM   293  C  C   . GLY A 1 41  ? 28.46665 -15.10346 -5.71035  1.000 16.22968 ? 41  GLY A C   1 
ATOM   294  O  O   . GLY A 1 41  ? 27.23973 -15.05729 -5.81331  1.000 16.75044 ? 41  GLY A O   1 
ATOM   295  N  N   . ILE A 1 42  ? 29.15412 -14.35739 -4.85035  1.000 12.33683 ? 42  ILE A N   1 
ATOM   296  C  CA  . ILE A 1 42  ? 28.51826 -13.39122 -3.96308  1.000 18.25083 ? 42  ILE A CA  1 
ATOM   297  C  C   . ILE A 1 42  ? 29.29684 -12.08607 -4.04227  1.000 18.84376 ? 42  ILE A C   1 
ATOM   298  O  O   . ILE A 1 42  ? 30.53045 -12.09293 -3.97836  1.000 17.86252 ? 42  ILE A O   1 
ATOM   299  C  CB  . ILE A 1 42  ? 28.46441 -13.89535 -2.50606  1.000 16.50288 ? 42  ILE A CB  1 
ATOM   300  C  CG1 . ILE A 1 42  ? 27.76711 -15.25541 -2.41980  1.000 13.49620 ? 42  ILE A CG1 1 
ATOM   301  C  CG2 . ILE A 1 42  ? 27.75842 -12.88712 -1.61400  1.000 13.36659 ? 42  ILE A CG2 1 
ATOM   302  C  CD1 . ILE A 1 42  ? 27.72374 -15.83019 -1.01907  1.000 11.65330 ? 42  ILE A CD1 1 
ATOM   303  N  N   . GLU A 1 43  ? 28.58460 -10.97069 -4.19041  1.000 14.70799 ? 43  GLU A N   1 
ATOM   304  C  CA  . GLU A 1 43  ? 29.20504 -9.65369  -4.05015  1.000 18.43858 ? 43  GLU A CA  1 
ATOM   305  C  C   . GLU A 1 43  ? 29.32095 -9.37622  -2.55588  1.000 17.06999 ? 43  GLU A C   1 
ATOM   306  O  O   . GLU A 1 43  ? 28.44968 -8.76124  -1.93654  1.000 14.82541 ? 43  GLU A O   1 
ATOM   307  C  CB  . GLU A 1 43  ? 28.39971 -8.58396  -4.77663  1.000 15.82074 ? 43  GLU A CB  1 
ATOM   308  C  CG  . GLU A 1 43  ? 28.98124 -7.18331  -4.65329  1.000 16.78859 ? 43  GLU A CG  1 
ATOM   309  C  CD  . GLU A 1 43  ? 28.29721 -6.18091  -5.56001  1.000 15.31264 ? 43  GLU A CD  1 
ATOM   310  O  OE1 . GLU A 1 43  ? 28.40303 -6.32354  -6.79649  1.000 16.70551 ? 43  GLU A OE1 1 
ATOM   311  O  OE2 . GLU A 1 43  ? 27.65138 -5.24969  -5.03544  1.000 16.69899 ? 43  GLU A OE2 1 
ATOM   312  N  N   . ALA A 1 44  ? 30.42111 -9.85488  -1.96997  1.000 18.62660 ? 44  ALA A N   1 
ATOM   313  C  CA  . ALA A 1 44  ? 30.58662 -9.83747  -0.52162  1.000 12.71447 ? 44  ALA A CA  1 
ATOM   314  C  C   . ALA A 1 44  ? 30.70868 -8.42979  0.04515   1.000 16.95568 ? 44  ALA A C   1 
ATOM   315  O  O   . ALA A 1 44  ? 30.50117 -8.24294  1.24885   1.000 16.67762 ? 44  ALA A O   1 
ATOM   316  C  CB  . ALA A 1 44  ? 31.81285 -10.66284 -0.12755  1.000 13.83161 ? 44  ALA A CB  1 
ATOM   317  N  N   . SER A 1 45  ? 31.03769 -7.43954  -0.78335  1.000 16.62278 ? 45  SER A N   1 
ATOM   318  C  CA  . SER A 1 45  ? 31.19003 -6.07596  -0.29518  1.000 15.09861 ? 45  SER A CA  1 
ATOM   319  C  C   . SER A 1 45  ? 29.86583 -5.33457  -0.17762  1.000 18.58188 ? 45  SER A C   1 
ATOM   320  O  O   . SER A 1 45  ? 29.85995 -4.19007  0.28842   1.000 16.46530 ? 45  SER A O   1 
ATOM   321  C  CB  . SER A 1 45  ? 32.13486 -5.29079  -1.20774  1.000 17.87116 ? 45  SER A CB  1 
ATOM   322  O  OG  . SER A 1 45  ? 31.59906 -5.16593  -2.51262  1.000 19.46733 ? 45  SER A OG  1 
ATOM   323  N  N   . HIS A 1 46  ? 28.76078 -5.95110  -0.58526  1.000 14.30886 ? 46  HIS A N   1 
ATOM   324  C  CA  . HIS A 1 46  ? 27.45674 -5.31418  -0.49635  1.000 13.20181 ? 46  HIS A CA  1 
ATOM   325  C  C   . HIS A 1 46  ? 27.16702 -4.92978  0.95414   1.000 13.90073 ? 46  HIS A C   1 
ATOM   326  O  O   . HIS A 1 46  ? 27.35997 -5.75613  1.85719   1.000 14.15195 ? 46  HIS A O   1 
ATOM   327  C  CB  . HIS A 1 46  ? 26.37588 -6.26224  -1.02113  1.000 13.18439 ? 46  HIS A CB  1 
ATOM   328  C  CG  . HIS A 1 46  ? 25.10938 -5.57702  -1.43016  1.000 13.52899 ? 46  HIS A CG  1 
ATOM   329  N  ND1 . HIS A 1 46  ? 24.35770 -4.81722  -0.56009  1.000 11.45252 ? 46  HIS A ND1 1 
ATOM   330  C  CD2 . HIS A 1 46  ? 24.45492 -5.54993  -2.61542  1.000 12.09997 ? 46  HIS A CD2 1 
ATOM   331  C  CE1 . HIS A 1 46  ? 23.29953 -4.34438  -1.19390  1.000 13.79849 ? 46  HIS A CE1 1 
ATOM   332  N  NE2 . HIS A 1 46  ? 23.33499 -4.77390  -2.44248  1.000 16.22685 ? 46  HIS A NE2 1 
ATOM   333  N  N   . PRO A 1 47  ? 26.73065 -3.69463  1.21995   1.000 17.61314 ? 47  PRO A N   1 
ATOM   334  C  CA  . PRO A 1 47  ? 26.47682 -3.29314  2.61439   1.000 17.31879 ? 47  PRO A CA  1 
ATOM   335  C  C   . PRO A 1 47  ? 25.45530 -4.16229  3.32561   1.000 17.67412 ? 47  PRO A C   1 
ATOM   336  O  O   . PRO A 1 47  ? 25.51380 -4.28784  4.55544   1.000 15.20545 ? 47  PRO A O   1 
ATOM   337  C  CB  . PRO A 1 47  ? 25.98243 -1.84651  2.47426   1.000 15.07953 ? 47  PRO A CB  1 
ATOM   338  C  CG  . PRO A 1 47  ? 26.56404 -1.37174  1.19092   1.000 19.92832 ? 47  PRO A CG  1 
ATOM   339  C  CD  . PRO A 1 47  ? 26.58043 -2.56812  0.28285   1.000 17.42965 ? 47  PRO A CD  1 
ATOM   340  N  N   . GLU A 1 48  ? 24.52760 -4.77776  2.58882   1.000 18.04229 ? 48  GLU A N   1 
ATOM   341  C  CA  . GLU A 1 48  ? 23.48985 -5.60543  3.19374   1.000 16.63906 ? 48  GLU A CA  1 
ATOM   342  C  C   . GLU A 1 48  ? 24.03242 -6.86950  3.84869   1.000 15.15707 ? 48  GLU A C   1 
ATOM   343  O  O   . GLU A 1 48  ? 23.30944 -7.49607  4.63114   1.000 13.94206 ? 48  GLU A O   1 
ATOM   344  C  CB  . GLU A 1 48  ? 22.44383 -5.98051  2.14225   1.000 16.24753 ? 48  GLU A CB  1 
ATOM   345  C  CG  . GLU A 1 48  ? 21.40160 -4.90136  1.89801   1.000 20.79858 ? 48  GLU A CG  1 
ATOM   346  C  CD  . GLU A 1 48  ? 20.44831 -4.74119  3.06798   1.000 23.49583 ? 48  GLU A CD  1 
ATOM   347  O  OE1 . GLU A 1 48  ? 20.27099 -5.71503  3.83181   1.000 21.30712 ? 48  GLU A OE1 1 
ATOM   348  O  OE2 . GLU A 1 48  ? 19.87737 -3.64127  3.22932   1.000 24.53248 ? 48  GLU A OE2 1 
ATOM   349  N  N   . PHE A 1 49  ? 25.27128 -7.25980  3.55463   1.000 14.69955 ? 49  PHE A N   1 
ATOM   350  C  CA  . PHE A 1 49  ? 25.86499 -8.44570  4.15635   1.000 13.02652 ? 49  PHE A CA  1 
ATOM   351  C  C   . PHE A 1 49  ? 26.64187 -8.14121  5.42996   1.000 17.12034 ? 49  PHE A C   1 
ATOM   352  O  O   . PHE A 1 49  ? 26.95345 -9.07187  6.18098   1.000 9.83733  ? 49  PHE A O   1 
ATOM   353  C  CB  . PHE A 1 49  ? 26.77304 -9.15031  3.14208   1.000 14.37614 ? 49  PHE A CB  1 
ATOM   354  C  CG  . PHE A 1 49  ? 26.02368 -9.77111  1.99769   1.000 9.21990  ? 49  PHE A CG  1 
ATOM   355  C  CD1 . PHE A 1 49  ? 24.87273 -10.50697 2.22891   1.000 17.33234 ? 49  PHE A CD1 1 
ATOM   356  C  CD2 . PHE A 1 49  ? 26.45375 -9.60166  0.69287   1.000 15.55282 ? 49  PHE A CD2 1 
ATOM   357  C  CE1 . PHE A 1 49  ? 24.17247 -11.07448 1.18139   1.000 18.80182 ? 49  PHE A CE1 1 
ATOM   358  C  CE2 . PHE A 1 49  ? 25.75688 -10.16586 -0.35850  1.000 17.27167 ? 49  PHE A CE2 1 
ATOM   359  C  CZ  . PHE A 1 49  ? 24.61443 -10.90384 -0.11448  1.000 14.64392 ? 49  PHE A CZ  1 
ATOM   360  N  N   . GLU A 1 50  ? 26.95688 -6.86944  5.68528   1.000 12.34173 ? 50  GLU A N   1 
ATOM   361  C  CA  . GLU A 1 50  ? 27.55319 -6.42502  6.94612   1.000 16.53455 ? 50  GLU A CA  1 
ATOM   362  C  C   . GLU A 1 50  ? 28.87122 -7.13390  7.24667   1.000 16.19025 ? 50  GLU A C   1 
ATOM   363  O  O   . GLU A 1 50  ? 29.23231 -7.32445  8.40984   1.000 16.16588 ? 50  GLU A O   1 
ATOM   364  C  CB  . GLU A 1 50  ? 26.57305 -6.60536  8.10873   1.000 14.42823 ? 50  GLU A CB  1 
ATOM   365  C  CG  . GLU A 1 50  ? 25.27279 -5.83690  7.94362   1.000 18.21301 ? 50  GLU A CG  1 
ATOM   366  C  CD  . GLU A 1 50  ? 24.24485 -6.20569  8.99154   1.000 19.16201 ? 50  GLU A CD  1 
ATOM   367  O  OE1 . GLU A 1 50  ? 23.94124 -7.40968  9.13065   1.000 22.37864 ? 50  GLU A OE1 1 
ATOM   368  O  OE2 . GLU A 1 50  ? 23.74746 -5.29325  9.68388   1.000 22.06209 ? 50  GLU A OE2 1 
ATOM   369  N  N   . GLY A 1 51  ? 29.60435 -7.52313  6.20682   1.000 11.74840 ? 51  GLY A N   1 
ATOM   370  C  CA  . GLY A 1 51  ? 30.86394 -8.21197  6.39424   1.000 12.98326 ? 51  GLY A CA  1 
ATOM   371  C  C   . GLY A 1 51  ? 30.74954 -9.66784  6.78005   1.000 16.55237 ? 51  GLY A C   1 
ATOM   372  O  O   . GLY A 1 51  ? 31.76038 -10.27373 7.15290   1.000 17.34805 ? 51  GLY A O   1 
ATOM   373  N  N   . ARG A 1 52  ? 29.55593 -10.25040 6.69900   1.000 13.97310 ? 52  ARG A N   1 
ATOM   374  C  CA  . ARG A 1 52  ? 29.32505 -11.63595 7.08417   1.000 11.81228 ? 52  ARG A CA  1 
ATOM   375  C  C   . ARG A 1 52  ? 29.42044 -12.60792 5.91338   1.000 15.06284 ? 52  ARG A C   1 
ATOM   376  O  O   . ARG A 1 52  ? 29.16519 -13.80247 6.09738   1.000 17.96347 ? 52  ARG A O   1 
ATOM   377  C  CB  . ARG A 1 52  ? 27.95286 -11.76848 7.75897   1.000 14.00418 ? 52  ARG A CB  1 
ATOM   378  C  CG  . ARG A 1 52  ? 27.86319 -11.08105 9.11626   1.000 18.24500 ? 52  ARG A CG  1 
ATOM   379  C  CD  . ARG A 1 52  ? 26.47849 -11.21538 9.73679   1.000 17.02663 ? 52  ARG A CD  1 
ATOM   380  N  NE  . ARG A 1 52  ? 25.50117 -10.33100 9.11281   1.000 16.68928 ? 52  ARG A NE  1 
ATOM   381  C  CZ  . ARG A 1 52  ? 24.61931 -10.71174 8.19890   1.000 16.83963 ? 52  ARG A CZ  1 
ATOM   382  N  NH1 . ARG A 1 52  ? 24.56673 -11.96138 7.76780   1.000 10.36135 ? 52  ARG A NH1 1 
ATOM   383  N  NH2 . ARG A 1 52  ? 23.76652 -9.81670  7.70785   1.000 10.76566 ? 52  ARG A NH2 1 
ATOM   384  N  N   . ALA A 1 53  ? 29.78197 -12.13522 4.72451   1.000 11.92214 ? 53  ALA A N   1 
ATOM   385  C  CA  . ALA A 1 53  ? 29.88177 -12.97984 3.54598   1.000 15.54335 ? 53  ALA A CA  1 
ATOM   386  C  C   . ALA A 1 53  ? 31.28950 -12.90588 2.97508   1.000 17.00506 ? 53  ALA A C   1 
ATOM   387  O  O   . ALA A 1 53  ? 31.95512 -11.86951 3.05721   1.000 13.77218 ? 53  ALA A O   1 
ATOM   388  C  CB  . ALA A 1 53  ? 28.86467 -12.57109 2.47294   1.000 14.05104 ? 53  ALA A CB  1 
ATOM   389  N  N   . GLN A 1 54  ? 31.73731 -14.01668 2.39197   1.000 12.98912 ? 54  GLN A N   1 
ATOM   390  C  CA  . GLN A 1 54  ? 33.06553 -14.07577 1.79732   1.000 15.59281 ? 54  GLN A CA  1 
ATOM   391  C  C   . GLN A 1 54  ? 33.11385 -15.21009 0.78403   1.000 14.75553 ? 54  GLN A C   1 
ATOM   392  O  O   . GLN A 1 54  ? 32.48904 -16.25881 0.97284   1.000 13.52622 ? 54  GLN A O   1 
ATOM   393  C  CB  . GLN A 1 54  ? 34.15314 -14.26111 2.86434   1.000 26.17868 ? 54  GLN A CB  1 
ATOM   394  C  CG  . GLN A 1 54  ? 33.93050 -15.44150 3.80157   1.000 28.53944 ? 54  GLN A CG  1 
ATOM   395  C  CD  . GLN A 1 54  ? 35.15210 -15.75204 4.64428   1.000 40.84913 ? 54  GLN A CD  1 
ATOM   396  O  OE1 . GLN A 1 54  ? 35.86505 -16.72060 4.38592   1.000 42.20783 ? 54  GLN A OE1 1 
ATOM   397  N  NE2 . GLN A 1 54  ? 35.40026 -14.93008 5.65779   1.000 48.39410 ? 54  GLN A NE2 1 
ATOM   398  N  N   . MET A 1 55  ? 33.85583 -14.97749 -0.29680  1.000 11.50764 ? 55  MET A N   1 
ATOM   399  C  CA  . MET A 1 55  ? 34.10005 -16.00946 -1.29321  1.000 18.73450 ? 55  MET A CA  1 
ATOM   400  C  C   . MET A 1 55  ? 35.22609 -16.91931 -0.82227  1.000 15.96835 ? 55  MET A C   1 
ATOM   401  O  O   . MET A 1 55  ? 36.27218 -16.44411 -0.36860  1.000 19.93079 ? 55  MET A O   1 
ATOM   402  C  CB  . MET A 1 55  ? 34.45449 -15.38316 -2.64118  1.000 16.12258 ? 55  MET A CB  1 
ATOM   403  C  CG  . MET A 1 55  ? 33.30544 -14.65637 -3.31379  1.000 16.98982 ? 55  MET A CG  1 
ATOM   404  S  SD  . MET A 1 55  ? 32.00178 -15.78133 -3.84989  1.000 19.76904 ? 55  MET A SD  1 
ATOM   405  C  CE  . MET A 1 55  ? 32.91038 -16.85031 -4.95881  1.000 17.33625 ? 55  MET A CE  1 
ATOM   406  N  N   . VAL A 1 56  ? 35.00469 -18.22729 -0.91844  1.000 11.87512 ? 56  VAL A N   1 
ATOM   407  C  CA  . VAL A 1 56  ? 35.99878 -19.20395 -0.49576  1.000 13.81453 ? 56  VAL A CA  1 
ATOM   408  C  C   . VAL A 1 56  ? 36.52352 -20.05432 -1.64242  1.000 15.96068 ? 56  VAL A C   1 
ATOM   409  O  O   . VAL A 1 56  ? 37.58051 -20.68816 -1.48572  1.000 17.78426 ? 56  VAL A O   1 
ATOM   410  C  CB  . VAL A 1 56  ? 35.44520 -20.11269 0.62234   1.000 15.61626 ? 56  VAL A CB  1 
ATOM   411  C  CG1 . VAL A 1 56  ? 34.96559 -19.27622 1.79610   1.000 14.70702 ? 56  VAL A CG1 1 
ATOM   412  C  CG2 . VAL A 1 56  ? 34.32014 -20.98813 0.08673   1.000 10.98135 ? 56  VAL A CG2 1 
ATOM   413  N  N   . LYS A 1 57  ? 35.84262 -20.09848 -2.78601  1.000 13.79503 ? 57  LYS A N   1 
ATOM   414  C  CA  . LYS A 1 57  ? 36.25266 -20.96578 -3.88022  1.000 12.94856 ? 57  LYS A CA  1 
ATOM   415  C  C   . LYS A 1 57  ? 35.59680 -20.49778 -5.17018  1.000 14.15529 ? 57  LYS A C   1 
ATOM   416  O  O   . LYS A 1 57  ? 34.41704 -20.13618 -5.17957  1.000 17.18803 ? 57  LYS A O   1 
ATOM   417  C  CB  . LYS A 1 57  ? 35.87780 -22.42712 -3.59936  1.000 16.23981 ? 57  LYS A CB  1 
ATOM   418  C  CG  . LYS A 1 57  ? 36.24459 -23.40076 -4.70784  1.000 17.03602 ? 57  LYS A CG  1 
ATOM   419  C  CD  . LYS A 1 57  ? 37.75002 -23.55246 -4.83765  1.000 20.01615 ? 57  LYS A CD  1 
ATOM   420  C  CE  . LYS A 1 57  ? 38.11119 -24.56168 -5.91671  1.000 24.28466 ? 57  LYS A CE  1 
ATOM   421  N  NZ  . LYS A 1 57  ? 39.58140 -24.79345 -5.99787  1.000 27.09410 ? 57  LYS A NZ  1 
ATOM   422  N  N   . THR A 1 58  ? 36.37133 -20.50982 -6.25182  1.000 14.43298 ? 58  THR A N   1 
ATOM   423  C  CA  . THR A 1 58  ? 35.84756 -20.27199 -7.58613  1.000 14.29924 ? 58  THR A CA  1 
ATOM   424  C  C   . THR A 1 58  ? 36.50310 -21.24968 -8.54851  1.000 18.96768 ? 58  THR A C   1 
ATOM   425  O  O   . THR A 1 58  ? 37.64980 -21.66397 -8.35604  1.000 21.59036 ? 58  THR A O   1 
ATOM   426  C  CB  . THR A 1 58  ? 36.08299 -18.82924 -8.05803  1.000 14.98156 ? 58  THR A CB  1 
ATOM   427  O  OG1 . THR A 1 58  ? 35.50026 -18.65207 -9.35566  1.000 17.81071 ? 58  THR A OG1 1 
ATOM   428  C  CG2 . THR A 1 58  ? 37.57312 -18.51680 -8.12608  1.000 14.98692 ? 58  THR A CG2 1 
ATOM   429  N  N   . TYR A 1 59  ? 35.75421 -21.62954 -9.57969  1.000 18.36044 ? 59  TYR A N   1 
ATOM   430  C  CA  . TYR A 1 59  ? 36.24453 -22.54027 -10.60266 1.000 20.13514 ? 59  TYR A CA  1 
ATOM   431  C  C   . TYR A 1 59  ? 36.45408 -21.83828 -11.93516 1.000 18.24822 ? 59  TYR A C   1 
ATOM   432  O  O   . TYR A 1 59  ? 36.58425 -22.50451 -12.96716 1.000 17.74414 ? 59  TYR A O   1 
ATOM   433  C  CB  . TYR A 1 59  ? 35.28495 -23.72237 -10.75717 1.000 21.12669 ? 59  TYR A CB  1 
ATOM   434  C  CG  . TYR A 1 59  ? 35.27438 -24.64351 -9.55689  1.000 21.96288 ? 59  TYR A CG  1 
ATOM   435  C  CD1 . TYR A 1 59  ? 34.48685 -24.36368 -8.44903  1.000 18.34617 ? 59  TYR A CD1 1 
ATOM   436  C  CD2 . TYR A 1 59  ? 36.06091 -25.78713 -9.52827  1.000 20.35355 ? 59  TYR A CD2 1 
ATOM   437  C  CE1 . TYR A 1 59  ? 34.48068 -25.19978 -7.34724  1.000 18.85309 ? 59  TYR A CE1 1 
ATOM   438  C  CE2 . TYR A 1 59  ? 36.06144 -26.62777 -8.43322  1.000 21.08366 ? 59  TYR A CE2 1 
ATOM   439  C  CZ  . TYR A 1 59  ? 35.27161 -26.33123 -7.34593  1.000 22.25346 ? 59  TYR A CZ  1 
ATOM   440  O  OH  . TYR A 1 59  ? 35.27456 -27.17194 -6.25642  1.000 14.68155 ? 59  TYR A OH  1 
ATOM   441  N  N   . TYR A 1 60  ? 36.48942 -20.50745 -11.93427 1.000 17.80390 ? 60  TYR A N   1 
ATOM   442  C  CA  . TYR A 1 60  ? 36.69567 -19.74182 -13.15467 1.000 18.17644 ? 60  TYR A CA  1 
ATOM   443  C  C   . TYR A 1 60  ? 37.80170 -18.71627 -12.93983 1.000 19.81672 ? 60  TYR A C   1 
ATOM   444  O  O   . TYR A 1 60  ? 38.53132 -18.78511 -11.94489 1.000 24.52944 ? 60  TYR A O   1 
ATOM   445  C  CB  . TYR A 1 60  ? 35.38744 -19.07637 -13.59077 1.000 19.67850 ? 60  TYR A CB  1 
ATOM   446  C  CG  . TYR A 1 60  ? 34.27133 -20.06993 -13.83797 1.000 19.55435 ? 60  TYR A CG  1 
ATOM   447  C  CD1 . TYR A 1 60  ? 33.41913 -20.45908 -12.80993 1.000 20.80769 ? 60  TYR A CD1 1 
ATOM   448  C  CD2 . TYR A 1 60  ? 34.08081 -20.63211 -15.09460 1.000 20.67552 ? 60  TYR A CD2 1 
ATOM   449  C  CE1 . TYR A 1 60  ? 32.40316 -21.37344 -13.02953 1.000 19.11341 ? 60  TYR A CE1 1 
ATOM   450  C  CE2 . TYR A 1 60  ? 33.06700 -21.54729 -15.32368 1.000 24.32551 ? 60  TYR A CE2 1 
ATOM   451  C  CZ  . TYR A 1 60  ? 32.23254 -21.91270 -14.28839 1.000 19.59542 ? 60  TYR A CZ  1 
ATOM   452  O  OH  . TYR A 1 60  ? 31.22466 -22.82091 -14.51337 1.000 26.67294 ? 60  TYR A OH  1 
ATOM   453  N  N   . TYR A 1 61  ? 37.93566 -17.76347 -13.86449 1.000 21.90816 ? 61  TYR A N   1 
ATOM   454  C  CA  . TYR A 1 61  ? 39.06243 -16.83775 -13.81046 1.000 22.23388 ? 61  TYR A CA  1 
ATOM   455  C  C   . TYR A 1 61  ? 38.97977 -15.90424 -12.61009 1.000 23.75121 ? 61  TYR A C   1 
ATOM   456  O  O   . TYR A 1 61  ? 40.01603 -15.52105 -12.05522 1.000 23.14521 ? 61  TYR A O   1 
ATOM   457  C  CB  . TYR A 1 61  ? 39.13650 -16.02972 -15.10371 1.000 21.67584 ? 61  TYR A CB  1 
ATOM   458  C  CG  . TYR A 1 61  ? 39.06856 -16.88023 -16.35055 1.000 31.36386 ? 61  TYR A CG  1 
ATOM   459  C  CD1 . TYR A 1 61  ? 40.18356 -17.56876 -16.80669 1.000 23.74290 ? 61  TYR A CD1 1 
ATOM   460  C  CD2 . TYR A 1 61  ? 37.88825 -16.99565 -17.07190 1.000 31.76690 ? 61  TYR A CD2 1 
ATOM   461  C  CE1 . TYR A 1 61  ? 40.12525 -18.35007 -17.94904 1.000 24.74436 ? 61  TYR A CE1 1 
ATOM   462  C  CE2 . TYR A 1 61  ? 37.82001 -17.77361 -18.21422 1.000 29.99088 ? 61  TYR A CE2 1 
ATOM   463  C  CZ  . TYR A 1 61  ? 38.94086 -18.44855 -18.64903 1.000 25.78279 ? 61  TYR A CZ  1 
ATOM   464  O  OH  . TYR A 1 61  ? 38.87719 -19.22350 -19.78619 1.000 29.44994 ? 61  TYR A OH  1 
ATOM   465  N  N   . SER A 1 62  ? 37.77210 -15.52776 -12.19758 1.000 17.03778 ? 62  SER A N   1 
ATOM   466  C  CA  . SER A 1 62  ? 37.57652 -14.63355 -11.06761 1.000 21.14821 ? 62  SER A CA  1 
ATOM   467  C  C   . SER A 1 62  ? 36.56002 -15.23151 -10.10438 1.000 20.80261 ? 62  SER A C   1 
ATOM   468  O  O   . SER A 1 62  ? 35.81346 -16.15343 -10.44396 1.000 19.33933 ? 62  SER A O   1 
ATOM   469  C  CB  . SER A 1 62  ? 37.11310 -13.24266 -11.52686 1.000 25.78320 ? 62  SER A CB  1 
ATOM   470  O  OG  . SER A 1 62  ? 36.75866 -12.43077 -10.42170 1.000 20.28625 ? 62  SER A OG  1 
ATOM   471  N  N   . SER A 1 63  ? 36.55084 -14.69847 -8.88488  1.000 18.95378 ? 63  SER A N   1 
ATOM   472  C  CA  . SER A 1 63  ? 35.56626 -15.06551 -7.87860  1.000 18.32770 ? 63  SER A CA  1 
ATOM   473  C  C   . SER A 1 63  ? 34.41951 -14.06976 -7.80323  1.000 20.44984 ? 63  SER A C   1 
ATOM   474  O  O   . SER A 1 63  ? 33.48600 -14.27308 -7.02089  1.000 25.06911 ? 63  SER A O   1 
ATOM   475  C  CB  . SER A 1 63  ? 36.23478 -15.19512 -6.50588  1.000 18.93088 ? 63  SER A CB  1 
ATOM   476  O  OG  . SER A 1 63  ? 36.82264 -13.96840 -6.11172  1.000 24.78154 ? 63  SER A OG  1 
ATOM   477  N  N   . ARG A 1 64  ? 34.46540 -13.00659 -8.59954  1.000 19.75350 ? 64  ARG A N   1 
ATOM   478  C  CA  . ARG A 1 64  ? 33.41272 -12.00497 -8.57551  1.000 14.70260 ? 64  ARG A CA  1 
ATOM   479  C  C   . ARG A 1 64  ? 32.13629 -12.54589 -9.20753  1.000 22.54915 ? 64  ARG A C   1 
ATOM   480  O  O   . ARG A 1 64  ? 32.16664 -13.38842 -10.10919 1.000 17.76551 ? 64  ARG A O   1 
ATOM   481  C  CB  . ARG A 1 64  ? 33.86165 -10.74295 -9.31046  1.000 22.30696 ? 64  ARG A CB  1 
ATOM   482  N  N   . ASP A 1 65  ? 31.00366 -12.04425 -8.72437  1.000 15.62205 ? 65  ASP A N   1 
ATOM   483  C  CA  . ASP A 1 65  ? 29.69805 -12.38700 -9.28149  1.000 16.71121 ? 65  ASP A CA  1 
ATOM   484  C  C   . ASP A 1 65  ? 29.38790 -11.39178 -10.39439 1.000 16.92667 ? 65  ASP A C   1 
ATOM   485  O  O   . ASP A 1 65  ? 29.01119 -10.24686 -10.13390 1.000 17.39228 ? 65  ASP A O   1 
ATOM   486  C  CB  . ASP A 1 65  ? 28.62940 -12.37243 -8.19335  1.000 11.95944 ? 65  ASP A CB  1 
ATOM   487  C  CG  . ASP A 1 65  ? 27.25193 -12.73521 -8.71845  1.000 14.13598 ? 65  ASP A CG  1 
ATOM   488  O  OD1 . ASP A 1 65  ? 27.15697 -13.24181 -9.85581  1.000 12.54857 ? 65  ASP A OD1 1 
ATOM   489  O  OD2 . ASP A 1 65  ? 26.26009 -12.50773 -7.99451  1.000 11.68186 ? 65  ASP A OD2 1 
ATOM   490  N  N   . GLY A 1 66  ? 29.55241 -11.82617 -11.63938 1.000 17.93169 ? 66  GLY A N   1 
ATOM   491  C  CA  . GLY A 1 66  ? 29.23764 -11.01604 -12.79465 1.000 15.13064 ? 66  GLY A CA  1 
ATOM   492  C  C   . GLY A 1 66  ? 27.84404 -11.21538 -13.34518 1.000 20.41771 ? 66  GLY A C   1 
ATOM   493  O  O   . GLY A 1 66  ? 27.54906 -10.72787 -14.44075 1.000 18.57547 ? 66  GLY A O   1 
ATOM   494  N  N   . ASN A 1 67  ? 26.97594 -11.91749 -12.61878 1.000 19.14370 ? 67  ASN A N   1 
ATOM   495  C  CA  . ASN A 1 67  ? 25.61726 -12.20976 -13.05890 1.000 16.16668 ? 67  ASN A CA  1 
ATOM   496  C  C   . ASN A 1 67  ? 24.56692 -11.61433 -12.13588 1.000 17.14127 ? 67  ASN A C   1 
ATOM   497  O  O   . ASN A 1 67  ? 23.60964 -10.99602 -12.61282 1.000 19.46784 ? 67  ASN A O   1 
ATOM   498  C  CB  . ASN A 1 67  ? 25.41548 -13.73299 -13.16896 1.000 17.76137 ? 67  ASN A CB  1 
ATOM   499  C  CG  . ASN A 1 67  ? 24.04867 -14.10503 -13.71915 1.000 20.95024 ? 67  ASN A CG  1 
ATOM   500  O  OD1 . ASN A 1 67  ? 23.05201 -14.10427 -12.99507 1.000 18.09982 ? 67  ASN A OD1 1 
ATOM   501  N  ND2 . ASN A 1 67  ? 23.99799 -14.43256 -15.00532 1.000 16.86883 ? 67  ASN A ND2 1 
ATOM   502  N  N   . GLY A 1 68  ? 24.71907 -11.78433 -10.82351 1.000 13.95781 ? 68  GLY A N   1 
ATOM   503  C  CA  . GLY A 1 68  ? 23.76627 -11.31589 -9.83798  1.000 10.73362 ? 68  GLY A CA  1 
ATOM   504  C  C   . GLY A 1 68  ? 22.92302 -12.41388 -9.22467  1.000 11.47331 ? 68  GLY A C   1 
ATOM   505  O  O   . GLY A 1 68  ? 22.33844 -12.20547 -8.15107  1.000 13.85351 ? 68  GLY A O   1 
ATOM   506  N  N   . HIS A 1 69  ? 22.84585 -13.57742 -9.87549  1.000 13.29052 ? 69  HIS A N   1 
ATOM   507  C  CA  . HIS A 1 69  ? 21.99872 -14.66109 -9.38282  1.000 11.29673 ? 69  HIS A CA  1 
ATOM   508  C  C   . HIS A 1 69  ? 22.42940 -15.11285 -7.99087  1.000 12.77029 ? 69  HIS A C   1 
ATOM   509  O  O   . HIS A 1 69  ? 21.60706 -15.20661 -7.07193  1.000 13.51124 ? 69  HIS A O   1 
ATOM   510  C  CB  . HIS A 1 69  ? 22.03458 -15.83235 -10.36511 1.000 9.83503  ? 69  HIS A CB  1 
ATOM   511  C  CG  . HIS A 1 69  ? 21.00888 -16.88928 -10.09095 1.000 11.88203 ? 69  HIS A CG  1 
ATOM   512  N  ND1 . HIS A 1 69  ? 21.29919 -18.04924 -9.40488  1.000 13.95271 ? 69  HIS A ND1 1 
ATOM   513  C  CD2 . HIS A 1 69  ? 19.69912 -16.96950 -10.42715 1.000 12.43679 ? 69  HIS A CD2 1 
ATOM   514  C  CE1 . HIS A 1 69  ? 20.21116 -18.79447 -9.32340  1.000 13.41928 ? 69  HIS A CE1 1 
ATOM   515  N  NE2 . HIS A 1 69  ? 19.22618 -18.16206 -9.93561  1.000 17.55259 ? 69  HIS A NE2 1 
ATOM   516  N  N   . GLY A 1 70  ? 23.72245 -15.38688 -7.81365  1.000 13.01267 ? 70  GLY A N   1 
ATOM   517  C  CA  . GLY A 1 70  ? 24.19955 -15.83993 -6.51774  1.000 10.93537 ? 70  GLY A CA  1 
ATOM   518  C  C   . GLY A 1 70  ? 24.09171 -14.77875 -5.43886  1.000 13.30289 ? 70  GLY A C   1 
ATOM   519  O  O   . GLY A 1 70  ? 23.82963 -15.09325 -4.27425  1.000 11.96288 ? 70  GLY A O   1 
ATOM   520  N  N   . THR A 1 71  ? 24.30105 -13.51041 -5.80329  1.000 12.52761 ? 71  THR A N   1 
ATOM   521  C  CA  . THR A 1 71  ? 24.13203 -12.43347 -4.83223  1.000 13.26806 ? 71  THR A CA  1 
ATOM   522  C  C   . THR A 1 71  ? 22.67822 -12.32184 -4.39194  1.000 12.40728 ? 71  THR A C   1 
ATOM   523  O  O   . THR A 1 71  ? 22.39320 -12.03568 -3.22247  1.000 10.84489 ? 71  THR A O   1 
ATOM   524  C  CB  . THR A 1 71  ? 24.61652 -11.10650 -5.42127  1.000 17.21978 ? 71  THR A CB  1 
ATOM   525  O  OG1 . THR A 1 71  ? 25.99380 -11.22087 -5.79898  1.000 15.88738 ? 71  THR A OG1 1 
ATOM   526  C  CG2 . THR A 1 71  ? 24.47116 -9.98356  -4.40289  1.000 12.12396 ? 71  THR A CG2 1 
ATOM   527  N  N   . HIS A 1 72  ? 21.74475 -12.55695 -5.31664  1.000 11.28872 ? 72  HIS A N   1 
ATOM   528  C  CA  . HIS A 1 72  ? 20.32658 -12.47966 -4.98473  1.000 10.36629 ? 72  HIS A CA  1 
ATOM   529  C  C   . HIS A 1 72  ? 19.93371 -13.59091 -4.02064  1.000 11.57485 ? 72  HIS A C   1 
ATOM   530  O  O   . HIS A 1 72  ? 19.24508 -13.34964 -3.02241  1.000 13.10252 ? 72  HIS A O   1 
ATOM   531  C  CB  . HIS A 1 72  ? 19.49083 -12.54685 -6.26428  1.000 10.64082 ? 72  HIS A CB  1 
ATOM   532  C  CG  . HIS A 1 72  ? 18.06823 -12.11415 -6.08505  1.000 12.57855 ? 72  HIS A CG  1 
ATOM   533  N  ND1 . HIS A 1 72  ? 17.08769 -12.95574 -5.60539  1.000 12.82479 ? 72  HIS A ND1 1 
ATOM   534  C  CD2 . HIS A 1 72  ? 17.45970 -10.92926 -6.32950  1.000 11.10277 ? 72  HIS A CD2 1 
ATOM   535  C  CE1 . HIS A 1 72  ? 15.93770 -12.30719 -5.55814  1.000 13.78129 ? 72  HIS A CE1 1 
ATOM   536  N  NE2 . HIS A 1 72  ? 16.13579 -11.07594 -5.99328  1.000 10.68733 ? 72  HIS A NE2 1 
ATOM   537  N  N   . CYS A 1 73  ? 20.37937 -14.81895 -4.29834  1.000 13.25945 ? 73  CYS A N   1 
ATOM   538  C  CA  . CYS A 1 73  ? 20.03719 -15.94518 -3.43590  1.000 12.53579 ? 73  CYS A CA  1 
ATOM   539  C  C   . CYS A 1 73  ? 20.64949 -15.78553 -2.04996  1.000 10.69821 ? 73  CYS A C   1 
ATOM   540  O  O   . CYS A 1 73  ? 19.99334 -16.05833 -1.03751  1.000 8.32295  ? 73  CYS A O   1 
ATOM   541  C  CB  . CYS A 1 73  ? 20.49473 -17.25538 -4.07856  1.000 12.29087 ? 73  CYS A CB  1 
ATOM   542  S  SG  . CYS A 1 73  ? 19.68817 -17.64408 -5.64658  1.000 16.14044 ? 73  CYS A SG  1 
ATOM   543  N  N   . ALA A 1 74  ? 21.90765 -15.34367 -1.98313  1.000 10.15829 ? 74  ALA A N   1 
ATOM   544  C  CA  . ALA A 1 74  ? 22.55923 -15.17783 -0.68782  1.000 14.08933 ? 74  ALA A CA  1 
ATOM   545  C  C   . ALA A 1 74  ? 21.87333 -14.09808 0.13876   1.000 11.89743 ? 74  ALA A C   1 
ATOM   546  O  O   . ALA A 1 74  ? 21.79679 -14.20171 1.36904   1.000 14.33967 ? 74  ALA A O   1 
ATOM   547  C  CB  . ALA A 1 74  ? 24.04069 -14.85256 -0.87954  1.000 10.35701 ? 74  ALA A CB  1 
ATOM   548  N  N   . GLY A 1 75  ? 21.37050 -13.05210 -0.51990  1.000 10.39904 ? 75  GLY A N   1 
ATOM   549  C  CA  . GLY A 1 75  ? 20.63563 -12.02466 0.19821   1.000 12.00471 ? 75  GLY A CA  1 
ATOM   550  C  C   . GLY A 1 75  ? 19.36941 -12.55569 0.84172   1.000 12.90240 ? 75  GLY A C   1 
ATOM   551  O  O   . GLY A 1 75  ? 18.99653 -12.13465 1.93904   1.000 13.13271 ? 75  GLY A O   1 
ATOM   552  N  N   . THR A 1 76  ? 18.68946 -13.48796 0.16774   1.000 11.25984 ? 76  THR A N   1 
ATOM   553  C  CA  . THR A 1 76  ? 17.51573 -14.11887 0.76365   1.000 10.59277 ? 76  THR A CA  1 
ATOM   554  C  C   . THR A 1 76  ? 17.90062 -14.99959 1.94636   1.000 11.17187 ? 76  THR A C   1 
ATOM   555  O  O   . THR A 1 76  ? 17.12669 -15.13018 2.90287   1.000 12.36037 ? 76  THR A O   1 
ATOM   556  C  CB  . THR A 1 76  ? 16.76170 -14.93091 -0.29247  1.000 11.19309 ? 76  THR A CB  1 
ATOM   557  O  OG1 . THR A 1 76  ? 16.32477 -14.05689 -1.34034  1.000 13.98642 ? 76  THR A OG1 1 
ATOM   558  C  CG2 . THR A 1 76  ? 15.54795 -15.62195 0.31247   1.000 14.37614 ? 76  THR A CG2 1 
ATOM   559  N  N   . VAL A 1 77  ? 19.09282 -15.59521 1.90859   1.000 10.62791 ? 77  VAL A N   1 
ATOM   560  C  CA  . VAL A 1 77  ? 19.55273 -16.41403 3.02660   1.000 12.10257 ? 77  VAL A CA  1 
ATOM   561  C  C   . VAL A 1 77  ? 19.80681 -15.54593 4.25377   1.000 12.05862 ? 77  VAL A C   1 
ATOM   562  O  O   . VAL A 1 77  ? 19.21328 -15.75613 5.31776   1.000 11.30672 ? 77  VAL A O   1 
ATOM   563  C  CB  . VAL A 1 77  ? 20.81117 -17.20953 2.63766   1.000 11.80546 ? 77  VAL A CB  1 
ATOM   564  C  CG1 . VAL A 1 77  ? 21.38118 -17.91658 3.85741   1.000 14.59421 ? 77  VAL A CG1 1 
ATOM   565  C  CG2 . VAL A 1 77  ? 20.49458 -18.21511 1.55024   1.000 10.34649 ? 77  VAL A CG2 1 
ATOM   566  N  N   . GLY A 1 78  ? 20.68843 -14.55508 4.12549   1.000 11.59484 ? 78  GLY A N   1 
ATOM   567  C  CA  . GLY A 1 78  ? 21.10022 -13.81128 5.29952   1.000 12.75899 ? 78  GLY A CA  1 
ATOM   568  C  C   . GLY A 1 78  ? 21.54898 -12.37577 5.10974   1.000 16.34757 ? 78  GLY A C   1 
ATOM   569  O  O   . GLY A 1 78  ? 22.47323 -11.92702 5.79497   1.000 14.42005 ? 78  GLY A O   1 
ATOM   570  N  N   . SER A 1 79  ? 20.91863 -11.63751 4.20103   1.000 14.27259 ? 79  SER A N   1 
ATOM   571  C  CA  . SER A 1 79  ? 21.13224 -10.19947 4.20198   1.000 16.76957 ? 79  SER A CA  1 
ATOM   572  C  C   . SER A 1 79  ? 20.29966 -9.56193  5.31046   1.000 14.65840 ? 79  SER A C   1 
ATOM   573  O  O   . SER A 1 79  ? 19.35061 -10.15689 5.82853   1.000 15.26340 ? 79  SER A O   1 
ATOM   574  C  CB  . SER A 1 79  ? 20.77863 -9.58199  2.84783   1.000 13.32894 ? 79  SER A CB  1 
ATOM   575  O  OG  . SER A 1 79  ? 19.37834 -9.57158  2.63166   1.000 13.95828 ? 79  SER A OG  1 
ATOM   576  N  N   . ARG A 1 80  ? 20.66890 -8.33345  5.67741   1.000 17.35882 ? 80  ARG A N   1 
ATOM   577  C  CA  . ARG A 1 80  ? 20.01794 -7.68094  6.81002   1.000 20.39253 ? 80  ARG A CA  1 
ATOM   578  C  C   . ARG A 1 80  ? 18.54328 -7.41932  6.52840   1.000 16.96587 ? 80  ARG A C   1 
ATOM   579  O  O   . ARG A 1 80  ? 17.67406 -7.76798  7.33565   1.000 15.81584 ? 80  ARG A O   1 
ATOM   580  C  CB  . ARG A 1 80  ? 20.73865 -6.37826  7.15635   1.000 19.32185 ? 80  ARG A CB  1 
ATOM   581  C  CG  . ARG A 1 80  ? 20.04572 -5.56294  8.24066   1.000 22.41439 ? 80  ARG A CG  1 
ATOM   582  C  CD  . ARG A 1 80  ? 20.86648 -4.34857  8.63583   1.000 29.67471 ? 80  ARG A CD  1 
ATOM   583  N  NE  . ARG A 1 80  ? 21.32756 -3.60184  7.47222   1.000 29.18765 ? 80  ARG A NE  1 
ATOM   584  C  CZ  . ARG A 1 80  ? 20.62089 -2.66503  6.85568   1.000 39.10296 ? 80  ARG A CZ  1 
ATOM   585  N  NH1 . ARG A 1 80  ? 19.40458 -2.33832  7.26074   1.000 36.63174 ? 80  ARG A NH1 1 
ATOM   586  N  NH2 . ARG A 1 80  ? 21.14779 -2.04037  5.80634   1.000 43.37916 ? 80  ARG A NH2 1 
ATOM   587  N  N   . THR A 1 81  ? 18.23945 -6.81429  5.38166   1.000 14.74925 ? 81  THR A N   1 
ATOM   588  C  CA  . THR A 1 81  ? 16.86712 -6.42040  5.08787   1.000 16.62488 ? 81  THR A CA  1 
ATOM   589  C  C   . THR A 1 81  ? 16.05844 -7.54511  4.45031   1.000 15.51275 ? 81  THR A C   1 
ATOM   590  O  O   . THR A 1 81  ? 14.86946 -7.70200  4.75081   1.000 12.15583 ? 81  THR A O   1 
ATOM   591  C  CB  . THR A 1 81  ? 16.86106 -5.19094  4.17316   1.000 12.11886 ? 81  THR A CB  1 
ATOM   592  O  OG1 . THR A 1 81  ? 17.70352 -4.17479  4.73223   1.000 21.50702 ? 81  THR A OG1 1 
ATOM   593  C  CG2 . THR A 1 81  ? 15.45444 -4.63739  4.02768   1.000 20.46522 ? 81  THR A CG2 1 
ATOM   594  N  N   . TYR A 1 82  ? 16.68464 -8.34470  3.58901   1.000 16.49905 ? 82  TYR A N   1 
ATOM   595  C  CA  . TYR A 1 82  ? 15.97254 -9.29107  2.74074   1.000 13.47093 ? 82  TYR A CA  1 
ATOM   596  C  C   . TYR A 1 82  ? 16.23800 -10.74588 3.10872   1.000 14.10952 ? 82  TYR A C   1 
ATOM   597  O  O   . TYR A 1 82  ? 15.85841 -11.64488 2.34667   1.000 13.10345 ? 82  TYR A O   1 
ATOM   598  C  CB  . TYR A 1 82  ? 16.34098 -9.04437  1.27536   1.000 12.48548 ? 82  TYR A CB  1 
ATOM   599  C  CG  . TYR A 1 82  ? 16.38340 -7.57455  0.90825   1.000 13.78183 ? 82  TYR A CG  1 
ATOM   600  C  CD1 . TYR A 1 82  ? 15.21583 -6.87094  0.64587   1.000 16.29247 ? 82  TYR A CD1 1 
ATOM   601  C  CD2 . TYR A 1 82  ? 17.59039 -6.88934  0.83137   1.000 13.93482 ? 82  TYR A CD2 1 
ATOM   602  C  CE1 . TYR A 1 82  ? 15.24822 -5.53027  0.31623   1.000 17.92308 ? 82  TYR A CE1 1 
ATOM   603  C  CE2 . TYR A 1 82  ? 17.63157 -5.54541  0.50258   1.000 16.32016 ? 82  TYR A CE2 1 
ATOM   604  C  CZ  . TYR A 1 82  ? 16.45677 -4.87126  0.24434   1.000 15.95872 ? 82  TYR A CZ  1 
ATOM   605  O  OH  . TYR A 1 82  ? 16.48396 -3.53360  -0.08544  1.000 15.16476 ? 82  TYR A OH  1 
ATOM   606  N  N   . GLY A 1 83  ? 16.85497 -11.00602 4.26003   1.000 14.53663 ? 83  GLY A N   1 
ATOM   607  C  CA  . GLY A 1 83  ? 17.29558 -12.34145 4.62069   1.000 15.98786 ? 83  GLY A CA  1 
ATOM   608  C  C   . GLY A 1 83  ? 16.45448 -12.98657 5.70547   1.000 13.72698 ? 83  GLY A C   1 
ATOM   609  O  O   . GLY A 1 83  ? 15.83410 -12.30125 6.51958   1.000 12.20567 ? 83  GLY A O   1 
ATOM   610  N  N   . VAL A 1 84  ? 16.44742 -14.32124 5.71314   1.000 13.69343 ? 84  VAL A N   1 
ATOM   611  C  CA  . VAL A 1 84  ? 15.72992 -15.06834 6.74139   1.000 11.16775 ? 84  VAL A CA  1 
ATOM   612  C  C   . VAL A 1 84  ? 16.55080 -15.14540 8.02249   1.000 14.35882 ? 84  VAL A C   1 
ATOM   613  O  O   . VAL A 1 84  ? 16.04864 -14.86141 9.11626   1.000 10.57558 ? 84  VAL A O   1 
ATOM   614  C  CB  . VAL A 1 84  ? 15.36323 -16.47238 6.22469   1.000 12.24990 ? 84  VAL A CB  1 
ATOM   615  C  CG1 . VAL A 1 84  ? 14.62864 -17.25493 7.30133   1.000 16.87824 ? 84  VAL A CG1 1 
ATOM   616  C  CG2 . VAL A 1 84  ? 14.52742 -16.37598 4.95463   1.000 13.67887 ? 84  VAL A CG2 1 
ATOM   617  N  N   . ALA A 1 85  ? 17.81772 -15.53837 7.90712   1.000 9.03798  ? 85  ALA A N   1 
ATOM   618  C  CA  . ALA A 1 85  ? 18.73722 -15.65352 9.03878   1.000 12.14526 ? 85  ALA A CA  1 
ATOM   619  C  C   . ALA A 1 85  ? 19.71234 -14.48137 8.95975   1.000 12.74675 ? 85  ALA A C   1 
ATOM   620  O  O   . ALA A 1 85  ? 20.78205 -14.58391 8.35868   1.000 8.39834  ? 85  ALA A O   1 
ATOM   621  C  CB  . ALA A 1 85  ? 19.46617 -16.99616 9.01938   1.000 12.10693 ? 85  ALA A CB  1 
ATOM   622  N  N   . LYS A 1 86  ? 19.33898 -13.36665 9.58822   1.000 15.99669 ? 86  LYS A N   1 
ATOM   623  C  CA  . LYS A 1 86  ? 20.04043 -12.09937 9.40796   1.000 9.94981  ? 86  LYS A CA  1 
ATOM   624  C  C   . LYS A 1 86  ? 21.39289 -12.03585 10.11102  1.000 16.88338 ? 86  LYS A C   1 
ATOM   625  O  O   . LYS A 1 86  ? 22.05420 -10.99434 10.02761  1.000 14.48034 ? 86  LYS A O   1 
ATOM   626  C  CB  . LYS A 1 86  ? 19.15359 -10.94923 9.88984   1.000 14.14384 ? 86  LYS A CB  1 
ATOM   627  C  CG  . LYS A 1 86  ? 17.79208 -10.90832 9.21830   1.000 17.87523 ? 86  LYS A CG  1 
ATOM   628  C  CD  . LYS A 1 86  ? 16.93180 -9.78404  9.76564   1.000 19.33774 ? 86  LYS A CD  1 
ATOM   629  C  CE  . LYS A 1 86  ? 15.54535 -9.80995  9.14088   1.000 15.47926 ? 86  LYS A CE  1 
ATOM   630  N  NZ  . LYS A 1 86  ? 15.59308 -9.65385  7.65928   1.000 11.74095 ? 86  LYS A NZ  1 
ATOM   631  N  N   . LYS A 1 87  ? 21.83176 -13.09865 10.78815  1.000 11.27161 ? 87  LYS A N   1 
ATOM   632  C  CA  . LYS A 1 87  ? 23.11742 -13.08070 11.47515  1.000 14.42187 ? 87  LYS A CA  1 
ATOM   633  C  C   . LYS A 1 87  ? 23.98186 -14.29328 11.15036  1.000 13.24802 ? 87  LYS A C   1 
ATOM   634  O  O   . LYS A 1 87  ? 24.96543 -14.54319 11.85757  1.000 14.02413 ? 87  LYS A O   1 
ATOM   635  C  CB  . LYS A 1 87  ? 22.91465 -12.97767 12.99173  1.000 13.74259 ? 87  LYS A CB  1 
ATOM   636  C  CG  . LYS A 1 87  ? 22.40742 -11.61820 13.44588  1.000 16.95526 ? 87  LYS A CG  1 
ATOM   637  C  CD  . LYS A 1 87  ? 21.98746 -11.62840 14.90664  1.000 24.80327 ? 87  LYS A CD  1 
ATOM   638  C  CE  . LYS A 1 87  ? 21.50136 -10.25593 15.33924  1.000 33.63765 ? 87  LYS A CE  1 
ATOM   639  N  NZ  . LYS A 1 87  ? 20.49111 -9.71170  14.39345  1.000 49.18074 ? 87  LYS A NZ  1 
ATOM   640  N  N   . THR A 1 88  ? 23.64840 -15.04879 10.10856  1.000 12.30689 ? 88  THR A N   1 
ATOM   641  C  CA  . THR A 1 88  ? 24.43168 -16.21602 9.74413   1.000 16.16438 ? 88  THR A CA  1 
ATOM   642  C  C   . THR A 1 88  ? 25.67338 -15.80405 8.95799   1.000 14.50130 ? 88  THR A C   1 
ATOM   643  O  O   . THR A 1 88  ? 25.82051 -14.65845 8.52103   1.000 15.41060 ? 88  THR A O   1 
ATOM   644  C  CB  . THR A 1 88  ? 23.59285 -17.19211 8.92158   1.000 14.03546 ? 88  THR A CB  1 
ATOM   645  O  OG1 . THR A 1 88  ? 24.31211 -18.41992 8.75205   1.000 16.67716 ? 88  THR A OG1 1 
ATOM   646  C  CG2 . THR A 1 88  ? 23.28204 -16.60088 7.55143   1.000 13.61791 ? 88  THR A CG2 1 
ATOM   647  N  N   . GLN A 1 89  ? 26.57660 -16.76308 8.77814   1.000 17.05367 ? 89  GLN A N   1 
ATOM   648  C  CA  . GLN A 1 89  ? 27.78525 -16.55929 7.99304   1.000 14.91195 ? 89  GLN A CA  1 
ATOM   649  C  C   . GLN A 1 89  ? 27.59021 -17.15513 6.60650   1.000 16.97157 ? 89  GLN A C   1 
ATOM   650  O  O   . GLN A 1 89  ? 27.07621 -18.27104 6.47162   1.000 18.24108 ? 89  GLN A O   1 
ATOM   651  C  CB  . GLN A 1 89  ? 28.99383 -17.18753 8.68192   1.000 15.43186 ? 89  GLN A CB  1 
ATOM   652  N  N   . LEU A 1 90  ? 28.00052 -16.41107 5.58449   1.000 17.26214 ? 90  LEU A N   1 
ATOM   653  C  CA  . LEU A 1 90  ? 27.77789 -16.78583 4.19642   1.000 13.71641 ? 90  LEU A CA  1 
ATOM   654  C  C   . LEU A 1 90  ? 29.11045 -17.08515 3.52560   1.000 16.03640 ? 90  LEU A C   1 
ATOM   655  O  O   . LEU A 1 90  ? 30.05299 -16.29284 3.62573   1.000 17.22561 ? 90  LEU A O   1 
ATOM   656  C  CB  . LEU A 1 90  ? 27.04246 -15.67136 3.44774   1.000 16.19519 ? 90  LEU A CB  1 
ATOM   657  C  CG  . LEU A 1 90  ? 25.67593 -15.26767 4.00599   1.000 13.92909 ? 90  LEU A CG  1 
ATOM   658  C  CD1 . LEU A 1 90  ? 25.18495 -13.98102 3.36196   1.000 21.10111 ? 90  LEU A CD1 1 
ATOM   659  C  CD2 . LEU A 1 90  ? 24.66948 -16.38550 3.79730   1.000 16.49565 ? 90  LEU A CD2 1 
ATOM   660  N  N   . PHE A 1 91  ? 29.18614 -18.23020 2.85296   1.000 12.82277 ? 91  PHE A N   1 
ATOM   661  C  CA  . PHE A 1 91  ? 30.34725 -18.61129 2.06247   1.000 9.89273  ? 91  PHE A CA  1 
ATOM   662  C  C   . PHE A 1 91  ? 29.90655 -18.83729 0.62478   1.000 14.04753 ? 91  PHE A C   1 
ATOM   663  O  O   . PHE A 1 91  ? 28.91711 -19.53508 0.37893   1.000 12.16372 ? 91  PHE A O   1 
ATOM   664  C  CB  . PHE A 1 91  ? 31.01480 -19.87359 2.61376   1.000 11.87640 ? 91  PHE A CB  1 
ATOM   665  C  CG  . PHE A 1 91  ? 31.51088 -19.73471 4.02495   1.000 16.08444 ? 91  PHE A CG  1 
ATOM   666  C  CD1 . PHE A 1 91  ? 32.45577 -18.77365 4.35036   1.000 16.91387 ? 91  PHE A CD1 1 
ATOM   667  C  CD2 . PHE A 1 91  ? 31.04935 -20.57904 5.02245   1.000 17.61975 ? 91  PHE A CD2 1 
ATOM   668  C  CE1 . PHE A 1 91  ? 32.91859 -18.64883 5.64610   1.000 22.91672 ? 91  PHE A CE1 1 
ATOM   669  C  CE2 . PHE A 1 91  ? 31.51057 -20.45798 6.32061   1.000 24.88874 ? 91  PHE A CE2 1 
ATOM   670  C  CZ  . PHE A 1 91  ? 32.44587 -19.49117 6.63236   1.000 15.88401 ? 91  PHE A CZ  1 
ATOM   671  N  N   . GLY A 1 92  ? 30.64588 -18.26196 -0.31819  1.000 13.49671 ? 92  GLY A N   1 
ATOM   672  C  CA  . GLY A 1 92  ? 30.31069 -18.35838 -1.72621  1.000 12.11422 ? 92  GLY A CA  1 
ATOM   673  C  C   . GLY A 1 92  ? 31.21626 -19.33669 -2.44959  1.000 8.88762  ? 92  GLY A C   1 
ATOM   674  O  O   . GLY A 1 92  ? 32.43796 -19.32070 -2.27593  1.000 15.43397 ? 92  GLY A O   1 
ATOM   675  N  N   . VAL A 1 93  ? 30.59749 -20.18790 -3.26415  1.000 14.34848 ? 93  VAL A N   1 
ATOM   676  C  CA  . VAL A 1 93  ? 31.29921 -21.14208 -4.11513  1.000 12.06400 ? 93  VAL A CA  1 
ATOM   677  C  C   . VAL A 1 93  ? 30.79857 -20.92361 -5.53743  1.000 14.33951 ? 93  VAL A C   1 
ATOM   678  O  O   . VAL A 1 93  ? 29.64294 -21.23824 -5.84795  1.000 14.29579 ? 93  VAL A O   1 
ATOM   679  C  CB  . VAL A 1 93  ? 31.07562 -22.59451 -3.67199  1.000 11.35185 ? 93  VAL A CB  1 
ATOM   680  C  CG1 . VAL A 1 93  ? 31.87207 -23.54210 -4.55422  1.000 11.08782 ? 93  VAL A CG1 1 
ATOM   681  C  CG2 . VAL A 1 93  ? 31.45514 -22.77039 -2.20466  1.000 11.26729 ? 93  VAL A CG2 1 
ATOM   682  N  N   . LYS A 1 94  ? 31.66203 -20.39391 -6.40173  1.000 11.96450 ? 94  LYS A N   1 
ATOM   683  C  CA  . LYS A 1 94  ? 31.27109 -20.02369 -7.76160  1.000 16.73228 ? 94  LYS A CA  1 
ATOM   684  C  C   . LYS A 1 94  ? 31.49098 -21.21495 -8.68476  1.000 12.41854 ? 94  LYS A C   1 
ATOM   685  O  O   . LYS A 1 94  ? 32.59372 -21.45447 -9.17809  1.000 14.93434 ? 94  LYS A O   1 
ATOM   686  C  CB  . LYS A 1 94  ? 32.05066 -18.80100 -8.22718  1.000 9.90058  ? 94  LYS A CB  1 
ATOM   687  C  CG  . LYS A 1 94  ? 31.72476 -18.35992 -9.64431  1.000 13.92306 ? 94  LYS A CG  1 
ATOM   688  C  CD  . LYS A 1 94  ? 32.40884 -17.04756 -9.98034  1.000 15.28290 ? 94  LYS A CD  1 
ATOM   689  C  CE  . LYS A 1 94  ? 32.19362 -16.67363 -11.43304 1.000 17.38586 ? 94  LYS A CE  1 
ATOM   690  N  NZ  . LYS A 1 94  ? 30.75367 -16.56563 -11.78402 1.000 16.17429 ? 94  LYS A NZ  1 
ATOM   691  N  N   . VAL A 1 95  ? 30.41798 -21.97187 -8.92628  1.000 10.62754 ? 95  VAL A N   1 
ATOM   692  C  CA  . VAL A 1 95  ? 30.45441 -23.07306 -9.88455  1.000 10.89740 ? 95  VAL A CA  1 
ATOM   693  C  C   . VAL A 1 95  ? 29.78295 -22.71748 -11.20197 1.000 15.08197 ? 95  VAL A C   1 
ATOM   694  O  O   . VAL A 1 95  ? 29.91288 -23.47861 -12.17501 1.000 13.97346 ? 95  VAL A O   1 
ATOM   695  C  CB  . VAL A 1 95  ? 29.80735 -24.34754 -9.30331  1.000 14.10960 ? 95  VAL A CB  1 
ATOM   696  C  CG1 . VAL A 1 95  ? 30.52540 -24.76694 -8.03295  1.000 11.43005 ? 95  VAL A CG1 1 
ATOM   697  C  CG2 . VAL A 1 95  ? 28.32733 -24.11522 -9.04443  1.000 12.27518 ? 95  VAL A CG2 1 
ATOM   698  N  N   . LEU A 1 96  ? 29.07509 -21.59369 -11.26778 1.000 13.37314 ? 96  LEU A N   1 
ATOM   699  C  CA  . LEU A 1 96  ? 28.42441 -21.12824 -12.48268 1.000 15.82085 ? 96  LEU A CA  1 
ATOM   700  C  C   . LEU A 1 96  ? 29.15003 -19.89505 -13.00380 1.000 15.56747 ? 96  LEU A C   1 
ATOM   701  O  O   . LEU A 1 96  ? 29.62539 -19.06702 -12.21993 1.000 13.62618 ? 96  LEU A O   1 
ATOM   702  C  CB  . LEU A 1 96  ? 26.95026 -20.79972 -12.22344 1.000 16.11122 ? 96  LEU A CB  1 
ATOM   703  C  CG  . LEU A 1 96  ? 26.07648 -21.90474 -11.62349 1.000 18.16696 ? 96  LEU A CG  1 
ATOM   704  C  CD1 . LEU A 1 96  ? 24.69069 -21.37253 -11.29058 1.000 15.22159 ? 96  LEU A CD1 1 
ATOM   705  C  CD2 . LEU A 1 96  ? 25.98117 -23.09377 -12.56713 1.000 17.21199 ? 96  LEU A CD2 1 
ATOM   706  N  N   . ASP A 1 97  ? 29.23956 -19.77438 -14.32622 1.000 18.79905 ? 97  ASP A N   1 
ATOM   707  C  CA  . ASP A 1 97  ? 29.89860 -18.61830 -14.91180 1.000 18.70910 ? 97  ASP A CA  1 
ATOM   708  C  C   . ASP A 1 97  ? 28.97016 -17.40545 -14.85763 1.000 21.21589 ? 97  ASP A C   1 
ATOM   709  O  O   . ASP A 1 97  ? 27.83693 -17.47487 -14.37324 1.000 21.88722 ? 97  ASP A O   1 
ATOM   710  C  CB  . ASP A 1 97  ? 30.36282 -18.92689 -16.33719 1.000 24.77820 ? 97  ASP A CB  1 
ATOM   711  C  CG  . ASP A 1 97  ? 29.22553 -19.33069 -17.26739 1.000 23.61388 ? 97  ASP A CG  1 
ATOM   712  O  OD1 . ASP A 1 97  ? 28.06105 -18.94540 -17.03273 1.000 20.57760 ? 97  ASP A OD1 1 
ATOM   713  O  OD2 . ASP A 1 97  ? 29.50456 -20.04740 -18.25086 1.000 24.18970 ? 97  ASP A OD2 1 
ATOM   714  N  N   . ASP A 1 98  ? 29.45271 -16.27512 -15.37295 1.000 19.02015 ? 98  ASP A N   1 
ATOM   715  C  CA  . ASP A 1 98  ? 28.68256 -15.03768 -15.32323 1.000 22.84110 ? 98  ASP A CA  1 
ATOM   716  C  C   . ASP A 1 98  ? 27.48238 -15.03792 -16.26171 1.000 18.48461 ? 98  ASP A C   1 
ATOM   717  O  O   . ASP A 1 98  ? 26.72209 -14.06326 -16.25984 1.000 20.46370 ? 98  ASP A O   1 
ATOM   718  C  CB  . ASP A 1 98  ? 29.59373 -13.85021 -15.63100 1.000 21.99988 ? 98  ASP A CB  1 
ATOM   719  C  CG  . ASP A 1 98  ? 30.67281 -13.66521 -14.58404 1.000 24.55019 ? 98  ASP A CG  1 
ATOM   720  O  OD1 . ASP A 1 98  ? 30.46247 -14.10439 -13.43266 1.000 18.25276 ? 98  ASP A OD1 1 
ATOM   721  O  OD2 . ASP A 1 98  ? 31.72761 -13.08188 -14.90887 1.000 26.05921 ? 98  ASP A OD2 1 
ATOM   722  N  N   . ASN A 1 99  ? 27.29476 -16.08801 -17.05850 1.000 25.51274 ? 99  ASN A N   1 
ATOM   723  C  CA  . ASN A 1 99  ? 26.08307 -16.25672 -17.84735 1.000 25.93939 ? 99  ASN A CA  1 
ATOM   724  C  C   . ASN A 1 99  ? 25.04248 -17.11929 -17.14726 1.000 24.44390 ? 99  ASN A C   1 
ATOM   725  O  O   . ASN A 1 99  ? 23.91977 -17.24022 -17.64907 1.000 26.20237 ? 99  ASN A O   1 
ATOM   726  C  CB  . ASN A 1 99  ? 26.41776 -16.87181 -19.21122 1.000 24.79766 ? 99  ASN A CB  1 
ATOM   727  C  CG  . ASN A 1 99  ? 27.19260 -15.92415 -20.10426 1.000 29.99835 ? 99  ASN A CG  1 
ATOM   728  O  OD1 . ASN A 1 99  ? 26.88662 -14.73448 -20.18002 1.000 37.31017 ? 99  ASN A OD1 1 
ATOM   729  N  ND2 . ASN A 1 99  ? 28.20582 -16.44777 -20.78472 1.000 30.70759 ? 99  ASN A ND2 1 
ATOM   730  N  N   . GLY A 1 100 ? 25.38436 -17.71372 -16.00794 1.000 21.73002 ? 100 GLY A N   1 
ATOM   731  C  CA  . GLY A 1 100 ? 24.47770 -18.58523 -15.29429 1.000 19.68784 ? 100 GLY A CA  1 
ATOM   732  C  C   . GLY A 1 100 ? 24.56596 -20.04880 -15.65891 1.000 21.92721 ? 100 GLY A C   1 
ATOM   733  O  O   . GLY A 1 100 ? 23.70217 -20.82575 -15.23566 1.000 25.75737 ? 100 GLY A O   1 
ATOM   734  N  N   . SER A 1 101 ? 25.57581 -20.45336 -16.42295 1.000 20.51029 ? 101 SER A N   1 
ATOM   735  C  CA  . SER A 1 101 ? 25.73537 -21.83587 -16.84426 1.000 22.87233 ? 101 SER A CA  1 
ATOM   736  C  C   . SER A 1 101 ? 26.98219 -22.44556 -16.21600 1.000 21.84681 ? 101 SER A C   1 
ATOM   737  O  O   . SER A 1 101 ? 27.87454 -21.74324 -15.73200 1.000 19.41481 ? 101 SER A O   1 
ATOM   738  C  CB  . SER A 1 101 ? 25.82349 -21.94280 -18.37097 1.000 30.89766 ? 101 SER A CB  1 
ATOM   739  O  OG  . SER A 1 101 ? 27.11591 -21.58524 -18.82973 1.000 37.93148 ? 101 SER A OG  1 
ATOM   740  N  N   . GLY A 1 102 ? 27.03127 -23.77500 -16.23978 1.000 18.74983 ? 102 GLY A N   1 
ATOM   741  C  CA  . GLY A 1 102 ? 28.16164 -24.51973 -15.72166 1.000 22.85334 ? 102 GLY A CA  1 
ATOM   742  C  C   . GLY A 1 102 ? 28.06533 -25.99793 -16.04154 1.000 16.61941 ? 102 GLY A C   1 
ATOM   743  O  O   . GLY A 1 102 ? 26.96180 -26.53977 -16.15769 1.000 22.16296 ? 102 GLY A O   1 
ATOM   744  N  N   . GLN A 1 103 ? 29.20868 -26.66121 -16.19174 1.000 18.89518 ? 103 GLN A N   1 
ATOM   745  C  CA  . GLN A 1 103 ? 29.22238 -28.08362 -16.49741 1.000 17.60639 ? 103 GLN A CA  1 
ATOM   746  C  C   . GLN A 1 103 ? 28.99365 -28.90266 -15.23173 1.000 19.15779 ? 103 GLN A C   1 
ATOM   747  O  O   . GLN A 1 103 ? 29.32442 -28.47587 -14.12157 1.000 17.42667 ? 103 GLN A O   1 
ATOM   748  C  CB  . GLN A 1 103 ? 30.54688 -28.48054 -17.15304 1.000 21.85121 ? 103 GLN A CB  1 
ATOM   749  N  N   . TYR A 1 104 ? 28.41707 -30.09472 -15.41186 1.000 15.91034 ? 104 TYR A N   1 
ATOM   750  C  CA  . TYR A 1 104 ? 28.08837 -30.94088 -14.26763 1.000 17.57124 ? 104 TYR A CA  1 
ATOM   751  C  C   . TYR A 1 104 ? 29.33311 -31.32618 -13.47861 1.000 16.51551 ? 104 TYR A C   1 
ATOM   752  O  O   . TYR A 1 104 ? 29.28955 -31.41966 -12.24663 1.000 21.02860 ? 104 TYR A O   1 
ATOM   753  C  CB  . TYR A 1 104 ? 27.34692 -32.19255 -14.73343 1.000 19.57924 ? 104 TYR A CB  1 
ATOM   754  C  CG  . TYR A 1 104 ? 25.84527 -32.03802 -14.77880 1.000 20.56089 ? 104 TYR A CG  1 
ATOM   755  C  CD1 . TYR A 1 104 ? 25.21821 -30.95930 -14.17038 1.000 22.40716 ? 104 TYR A CD1 1 
ATOM   756  C  CD2 . TYR A 1 104 ? 25.05312 -32.97899 -15.42033 1.000 18.95937 ? 104 TYR A CD2 1 
ATOM   757  C  CE1 . TYR A 1 104 ? 23.84366 -30.81979 -14.20796 1.000 25.86462 ? 104 TYR A CE1 1 
ATOM   758  C  CE2 . TYR A 1 104 ? 23.68259 -32.84921 -15.46031 1.000 14.71233 ? 104 TYR A CE2 1 
ATOM   759  C  CZ  . TYR A 1 104 ? 23.08308 -31.76789 -14.85410 1.000 24.32434 ? 104 TYR A CZ  1 
ATOM   760  O  OH  . TYR A 1 104 ? 21.71651 -31.63950 -14.89665 1.000 23.19048 ? 104 TYR A OH  1 
ATOM   761  N  N   . SER A 1 105 ? 30.45148 -31.55997 -14.16988 1.000 15.28640 ? 105 SER A N   1 
ATOM   762  C  CA  . SER A 1 105 ? 31.68222 -31.93241 -13.47875 1.000 23.11627 ? 105 SER A CA  1 
ATOM   763  C  C   . SER A 1 105 ? 32.15830 -30.82818 -12.54372 1.000 18.85392 ? 105 SER A C   1 
ATOM   764  O  O   . SER A 1 105 ? 32.75345 -31.11368 -11.49824 1.000 17.92632 ? 105 SER A O   1 
ATOM   765  C  CB  . SER A 1 105 ? 32.77137 -32.27448 -14.49452 1.000 17.39601 ? 105 SER A CB  1 
ATOM   766  O  OG  . SER A 1 105 ? 33.04804 -31.16712 -15.33288 1.000 28.65955 ? 105 SER A OG  1 
ATOM   767  N  N   . THR A 1 106 ? 31.90430 -29.56667 -12.89805 1.000 15.71268 ? 106 THR A N   1 
ATOM   768  C  CA  . THR A 1 106 ? 32.26128 -28.46133 -12.01450 1.000 16.61135 ? 106 THR A CA  1 
ATOM   769  C  C   . THR A 1 106 ? 31.30114 -28.36516 -10.83409 1.000 20.46161 ? 106 THR A C   1 
ATOM   770  O  O   . THR A 1 106 ? 31.72488 -28.11270 -9.69978  1.000 14.62924 ? 106 THR A O   1 
ATOM   771  C  CB  . THR A 1 106 ? 32.27601 -27.15030 -12.79883 1.000 23.14200 ? 106 THR A CB  1 
ATOM   772  O  OG1 . THR A 1 106 ? 33.20557 -27.25265 -13.88496 1.000 26.33844 ? 106 THR A OG1 1 
ATOM   773  C  CG2 . THR A 1 106 ? 32.67369 -25.98931 -11.89616 1.000 20.91657 ? 106 THR A CG2 1 
ATOM   774  N  N   . ILE A 1 107 ? 30.00345 -28.55791 -11.08291 1.000 16.74143 ? 107 ILE A N   1 
ATOM   775  C  CA  . ILE A 1 107 ? 29.02089 -28.53078 -10.00211 1.000 15.43719 ? 107 ILE A CA  1 
ATOM   776  C  C   . ILE A 1 107 ? 29.29256 -29.65107 -9.00542  1.000 15.65434 ? 107 ILE A C   1 
ATOM   777  O  O   . ILE A 1 107 ? 29.15437 -29.46909 -7.78895  1.000 13.23009 ? 107 ILE A O   1 
ATOM   778  C  CB  . ILE A 1 107 ? 27.59632 -28.61540 -10.58158 1.000 14.65449 ? 107 ILE A CB  1 
ATOM   779  C  CG1 . ILE A 1 107 ? 27.30625 -27.38998 -11.45235 1.000 12.67320 ? 107 ILE A CG1 1 
ATOM   780  C  CG2 . ILE A 1 107 ? 26.56767 -28.74267 -9.46878  1.000 15.97877 ? 107 ILE A CG2 1 
ATOM   781  C  CD1 . ILE A 1 107 ? 26.03849 -27.50310 -12.26879 1.000 18.34759 ? 107 ILE A CD1 1 
ATOM   782  N  N   . ILE A 1 108 ? 29.68917 -30.82426 -9.50374  1.000 12.62280 ? 108 ILE A N   1 
ATOM   783  C  CA  . ILE A 1 108 ? 30.01564 -31.94267 -8.62181  1.000 9.84071  ? 108 ILE A CA  1 
ATOM   784  C  C   . ILE A 1 108 ? 31.22304 -31.60208 -7.75740  1.000 17.01265 ? 108 ILE A C   1 
ATOM   785  O  O   . ILE A 1 108 ? 31.22937 -31.84224 -6.54382  1.000 14.18422 ? 108 ILE A O   1 
ATOM   786  C  CB  . ILE A 1 108 ? 30.25637 -33.22089 -9.44499  1.000 14.85168 ? 108 ILE A CB  1 
ATOM   787  C  CG1 . ILE A 1 108 ? 28.94183 -33.73238 -10.03550 1.000 15.89332 ? 108 ILE A CG1 1 
ATOM   788  C  CG2 . ILE A 1 108 ? 30.92332 -34.29179 -8.59353  1.000 12.30639 ? 108 ILE A CG2 1 
ATOM   789  C  CD1 . ILE A 1 108 ? 29.11735 -34.87736 -11.00599 1.000 15.96791 ? 108 ILE A CD1 1 
ATOM   790  N  N   . ALA A 1 109 ? 32.26572 -31.03745 -8.37250  1.000 14.29730 ? 109 ALA A N   1 
ATOM   791  C  CA  . ALA A 1 109 ? 33.46479 -30.68130 -7.62049  1.000 14.53962 ? 109 ALA A CA  1 
ATOM   792  C  C   . ALA A 1 109 ? 33.15612 -29.65107 -6.54174  1.000 15.47086 ? 109 ALA A C   1 
ATOM   793  O  O   . ALA A 1 109 ? 33.76193 -29.66982 -5.46403  1.000 15.06130 ? 109 ALA A O   1 
ATOM   794  C  CB  . ALA A 1 109 ? 34.54391 -30.15938 -8.56851  1.000 15.60798 ? 109 ALA A CB  1 
ATOM   795  N  N   . GLY A 1 110 ? 32.21092 -28.74812 -6.81001  1.000 14.42999 ? 110 GLY A N   1 
ATOM   796  C  CA  . GLY A 1 110 ? 31.84309 -27.75925 -5.80945  1.000 12.51442 ? 110 GLY A CA  1 
ATOM   797  C  C   . GLY A 1 110 ? 31.19570 -28.37665 -4.58472  1.000 12.55897 ? 110 GLY A C   1 
ATOM   798  O  O   . GLY A 1 110 ? 31.44107 -27.94294 -3.45551  1.000 13.67047 ? 110 GLY A O   1 
ATOM   799  N  N   . MET A 1 111 ? 30.36019 -29.39847 -4.78995  1.000 13.59657 ? 111 MET A N   1 
ATOM   800  C  CA  . MET A 1 111 ? 29.72061 -30.06352 -3.66027  1.000 12.20077 ? 111 MET A CA  1 
ATOM   801  C  C   . MET A 1 111 ? 30.73313 -30.84696 -2.83625  1.000 13.98913 ? 111 MET A C   1 
ATOM   802  O  O   . MET A 1 111 ? 30.69327 -30.81201 -1.60097  1.000 13.75261 ? 111 MET A O   1 
ATOM   803  C  CB  . MET A 1 111 ? 28.60030 -30.97793 -4.15417  1.000 15.24857 ? 111 MET A CB  1 
ATOM   804  C  CG  . MET A 1 111 ? 27.42752 -30.22540 -4.74788  1.000 16.11782 ? 111 MET A CG  1 
ATOM   805  S  SD  . MET A 1 111 ? 25.95215 -31.24755 -4.92308  1.000 19.63850 ? 111 MET A SD  1 
ATOM   806  C  CE  . MET A 1 111 ? 25.89126 -31.46229 -6.69691  1.000 11.83088 ? 111 MET A CE  1 
ATOM   807  N  N   . ASP A 1 112 ? 31.64508 -31.56223 -3.50084  1.000 12.94345 ? 112 ASP A N   1 
ATOM   808  C  CA  . ASP A 1 112 ? 32.70554 -32.26050 -2.78037  1.000 13.91161 ? 112 ASP A CA  1 
ATOM   809  C  C   . ASP A 1 112 ? 33.57357 -31.28425 -1.99654  1.000 14.58495 ? 112 ASP A C   1 
ATOM   810  O  O   . ASP A 1 112 ? 34.05877 -31.60795 -0.90503  1.000 14.52981 ? 112 ASP A O   1 
ATOM   811  C  CB  . ASP A 1 112 ? 33.56267 -33.06586 -3.75681  1.000 13.18716 ? 112 ASP A CB  1 
ATOM   812  C  CG  . ASP A 1 112 ? 32.79801 -34.19476 -4.41015  1.000 21.34489 ? 112 ASP A CG  1 
ATOM   813  O  OD1 . ASP A 1 112 ? 31.88126 -34.74008 -3.76551  1.000 19.98211 ? 112 ASP A OD1 1 
ATOM   814  O  OD2 . ASP A 1 112 ? 33.11146 -34.53481 -5.56980  1.000 19.79030 ? 112 ASP A OD2 1 
ATOM   815  N  N   . PHE A 1 113 ? 33.78210 -30.08368 -2.54282  1.000 13.13850 ? 113 PHE A N   1 
ATOM   816  C  CA  . PHE A 1 113 ? 34.58495 -29.08054 -1.85330  1.000 13.20030 ? 113 PHE A CA  1 
ATOM   817  C  C   . PHE A 1 113 ? 33.93055 -28.65478 -0.54543  1.000 16.07998 ? 113 PHE A C   1 
ATOM   818  O  O   . PHE A 1 113 ? 34.60712 -28.52056 0.48105   1.000 13.95044 ? 113 PHE A O   1 
ATOM   819  C  CB  . PHE A 1 113 ? 34.80495 -27.87260 -2.76514  1.000 13.06740 ? 113 PHE A CB  1 
ATOM   820  C  CG  . PHE A 1 113 ? 35.43769 -26.69821 -2.07292  1.000 14.19579 ? 113 PHE A CG  1 
ATOM   821  C  CD1 . PHE A 1 113 ? 36.81236 -26.62414 -1.92206  1.000 14.92628 ? 113 PHE A CD1 1 
ATOM   822  C  CD2 . PHE A 1 113 ? 34.65750 -25.66526 -1.57583  1.000 17.38567 ? 113 PHE A CD2 1 
ATOM   823  C  CE1 . PHE A 1 113 ? 37.39638 -25.54707 -1.28374  1.000 18.52772 ? 113 PHE A CE1 1 
ATOM   824  C  CE2 . PHE A 1 113 ? 35.23533 -24.58799 -0.93516  1.000 16.66734 ? 113 PHE A CE2 1 
ATOM   825  C  CZ  . PHE A 1 113 ? 36.60675 -24.52717 -0.79099  1.000 13.86328 ? 113 PHE A CZ  1 
ATOM   826  N  N   . VAL A 1 114 ? 32.61316 -28.43881 -0.56299  1.000 11.74646 ? 114 VAL A N   1 
ATOM   827  C  CA  . VAL A 1 114 ? 31.91730 -27.97790 0.63565   1.000 13.61725 ? 114 VAL A CA  1 
ATOM   828  C  C   . VAL A 1 114 ? 31.97271 -29.03900 1.72787   1.000 12.89988 ? 114 VAL A C   1 
ATOM   829  O  O   . VAL A 1 114 ? 32.12135 -28.72285 2.91493   1.000 14.88284 ? 114 VAL A O   1 
ATOM   830  C  CB  . VAL A 1 114 ? 30.46822 -27.58494 0.29094   1.000 15.71595 ? 114 VAL A CB  1 
ATOM   831  C  CG1 . VAL A 1 114 ? 29.70710 -27.19646 1.54763   1.000 15.64085 ? 114 VAL A CG1 1 
ATOM   832  C  CG2 . VAL A 1 114 ? 30.45711 -26.43842 -0.71334  1.000 15.68160 ? 114 VAL A CG2 1 
ATOM   833  N  N   . ALA A 1 115 ? 31.86661 -30.31396 1.34498   1.000 14.61545 ? 115 ALA A N   1 
ATOM   834  C  CA  . ALA A 1 115 ? 31.94346 -31.39336 2.32599   1.000 16.53286 ? 115 ALA A CA  1 
ATOM   835  C  C   . ALA A 1 115 ? 33.28290 -31.39347 3.05063   1.000 18.04664 ? 115 ALA A C   1 
ATOM   836  O  O   . ALA A 1 115 ? 33.35483 -31.72732 4.24108   1.000 20.45199 ? 115 ALA A O   1 
ATOM   837  C  CB  . ALA A 1 115 ? 31.70629 -32.74054 1.64471   1.000 12.61923 ? 115 ALA A CB  1 
ATOM   838  N  N   . SER A 1 116 ? 34.35703 -31.02356 2.35104   1.000 14.45656 ? 116 SER A N   1 
ATOM   839  C  CA  . SER A 1 116 ? 35.66504 -31.00147 2.99386   1.000 15.70224 ? 116 SER A CA  1 
ATOM   840  C  C   . SER A 1 116 ? 35.94114 -29.65938 3.65951   1.000 19.39780 ? 116 SER A C   1 
ATOM   841  O  O   . SER A 1 116 ? 36.52648 -29.61125 4.74646   1.000 16.07598 ? 116 SER A O   1 
ATOM   842  C  CB  . SER A 1 116 ? 36.75169 -31.32222 1.97435   1.000 13.62496 ? 116 SER A CB  1 
ATOM   843  O  OG  . SER A 1 116 ? 38.04145 -31.12434 2.52522   1.000 21.25812 ? 116 SER A OG  1 
ATOM   844  N  N   . ASP A 1 117 ? 35.50342 -28.56366 3.03621   1.000 16.95026 ? 117 ASP A N   1 
ATOM   845  C  CA  . ASP A 1 117 ? 35.86160 -27.23635 3.52553   1.000 16.01501 ? 117 ASP A CA  1 
ATOM   846  C  C   . ASP A 1 117 ? 35.20289 -26.91249 4.86312   1.000 16.83322 ? 117 ASP A C   1 
ATOM   847  O  O   . ASP A 1 117 ? 35.74978 -26.12366 5.64102   1.000 17.85089 ? 117 ASP A O   1 
ATOM   848  C  CB  . ASP A 1 117 ? 35.49474 -26.18013 2.48422   1.000 15.42040 ? 117 ASP A CB  1 
ATOM   849  C  CG  . ASP A 1 117 ? 35.89893 -24.78724 2.90766   1.000 19.38583 ? 117 ASP A CG  1 
ATOM   850  O  OD1 . ASP A 1 117 ? 37.09657 -24.44464 2.78275   1.000 16.50526 ? 117 ASP A OD1 1 
ATOM   851  O  OD2 . ASP A 1 117 ? 35.02326 -24.03575 3.38946   1.000 17.02377 ? 117 ASP A OD2 1 
ATOM   852  N  N   . LYS A 1 118 ? 34.04249 -27.50436 5.15747   1.000 14.02918 ? 118 LYS A N   1 
ATOM   853  C  CA  . LYS A 1 118 ? 33.37457 -27.21670 6.42459   1.000 17.39442 ? 118 LYS A CA  1 
ATOM   854  C  C   . LYS A 1 118 ? 34.19833 -27.66344 7.62800   1.000 20.99323 ? 118 LYS A C   1 
ATOM   855  O  O   . LYS A 1 118 ? 33.98646 -27.15751 8.73655   1.000 20.69882 ? 118 LYS A O   1 
ATOM   856  C  CB  . LYS A 1 118 ? 31.99996 -27.88719 6.46650   1.000 18.94989 ? 118 LYS A CB  1 
ATOM   857  C  CG  . LYS A 1 118 ? 32.05949 -29.39223 6.64926   1.000 19.82726 ? 118 LYS A CG  1 
ATOM   858  C  CD  . LYS A 1 118 ? 30.68457 -29.96557 6.92228   1.000 27.26825 ? 118 LYS A CD  1 
ATOM   859  C  CE  . LYS A 1 118 ? 30.78886 -31.40227 7.40019   1.000 22.97683 ? 118 LYS A CE  1 
ATOM   860  N  NZ  . LYS A 1 118 ? 31.53065 -32.25232 6.42900   1.000 22.70968 ? 118 LYS A NZ  1 
ATOM   861  N  N   . ASN A 1 119 ? 35.14151 -28.58738 7.43292   1.000 21.54024 ? 119 ASN A N   1 
ATOM   862  C  CA  . ASN A 1 119 ? 35.91426 -29.13765 8.53964   1.000 22.17503 ? 119 ASN A CA  1 
ATOM   863  C  C   . ASN A 1 119 ? 36.94947 -28.16623 9.09115   1.000 21.99618 ? 119 ASN A C   1 
ATOM   864  O  O   . ASN A 1 119 ? 37.50398 -28.42884 10.16422  1.000 33.76273 ? 119 ASN A O   1 
ATOM   865  C  CB  . ASN A 1 119 ? 36.60134 -30.43135 8.10047   1.000 18.77653 ? 119 ASN A CB  1 
ATOM   866  C  CG  . ASN A 1 119 ? 35.61191 -31.51275 7.71538   1.000 26.60640 ? 119 ASN A CG  1 
ATOM   867  O  OD1 . ASN A 1 119 ? 34.54151 -31.63325 8.31265   1.000 25.42592 ? 119 ASN A OD1 1 
ATOM   868  N  ND2 . ASN A 1 119 ? 35.96540 -32.30750 6.71378   1.000 18.72297 ? 119 ASN A ND2 1 
ATOM   869  N  N   . ASN A 1 120 ? 37.22725 -27.06301 8.39291   1.000 23.57069 ? 120 ASN A N   1 
ATOM   870  C  CA  . ASN A 1 120 ? 38.13679 -26.03658 8.89072   1.000 27.53019 ? 120 ASN A CA  1 
ATOM   871  C  C   . ASN A 1 120 ? 37.43564 -24.69350 9.07769   1.000 25.55421 ? 120 ASN A C   1 
ATOM   872  O  O   . ASN A 1 120 ? 38.09374 -23.64830 9.09345   1.000 22.31521 ? 120 ASN A O   1 
ATOM   873  C  CB  . ASN A 1 120 ? 39.35201 -25.89449 7.96829   1.000 32.81770 ? 120 ASN A CB  1 
ATOM   874  C  CG  . ASN A 1 120 ? 38.97192 -25.74931 6.50655   1.000 30.18510 ? 120 ASN A CG  1 
ATOM   875  O  OD1 . ASN A 1 120 ? 38.14394 -24.91474 6.14632   1.000 41.58367 ? 120 ASN A OD1 1 
ATOM   876  N  ND2 . ASN A 1 120 ? 39.58201 -26.56618 5.65443   1.000 27.37581 ? 120 ASN A ND2 1 
ATOM   877  N  N   . ARG A 1 121 ? 36.11313 -24.70184 9.22164   1.000 20.49667 ? 121 ARG A N   1 
ATOM   878  C  CA  . ARG A 1 121 ? 35.33559 -23.50718 9.51264   1.000 21.22514 ? 121 ARG A CA  1 
ATOM   879  C  C   . ARG A 1 121 ? 34.72939 -23.61816 10.90591  1.000 25.42603 ? 121 ARG A C   1 
ATOM   880  O  O   . ARG A 1 121 ? 34.44865 -24.71800 11.39148  1.000 26.45630 ? 121 ARG A O   1 
ATOM   881  C  CB  . ARG A 1 121 ? 34.22257 -23.30081 8.47886   1.000 23.09694 ? 121 ARG A CB  1 
ATOM   882  C  CG  . ARG A 1 121 ? 34.69979 -23.28721 7.03759   1.000 21.19279 ? 121 ARG A CG  1 
ATOM   883  C  CD  . ARG A 1 121 ? 35.51557 -22.04530 6.72614   1.000 20.55642 ? 121 ARG A CD  1 
ATOM   884  N  NE  . ARG A 1 121 ? 36.10621 -22.11263 5.39534   1.000 19.00926 ? 121 ARG A NE  1 
ATOM   885  C  CZ  . ARG A 1 121 ? 36.86155 -21.16287 4.86203   1.000 28.51947 ? 121 ARG A CZ  1 
ATOM   886  N  NH1 . ARG A 1 121 ? 37.13161 -20.04530 5.51696   1.000 24.87911 ? 121 ARG A NH1 1 
ATOM   887  N  NH2 . ARG A 1 121 ? 37.35861 -21.33891 3.64113   1.000 18.13119 ? 121 ARG A NH2 1 
ATOM   888  N  N   . ASN A 1 122 ? 34.53175 -22.46864 11.54895  1.000 24.00863 ? 122 ASN A N   1 
ATOM   889  C  CA  . ASN A 1 122 ? 33.95394 -22.42029 12.89118  1.000 25.41782 ? 122 ASN A CA  1 
ATOM   890  C  C   . ASN A 1 122 ? 32.45322 -22.19610 12.75337  1.000 21.81465 ? 122 ASN A C   1 
ATOM   891  O  O   . ASN A 1 122 ? 31.99209 -21.06198 12.60428  1.000 24.05840 ? 122 ASN A O   1 
ATOM   892  C  CB  . ASN A 1 122 ? 34.61397 -21.32767 13.72368  1.000 24.82937 ? 122 ASN A CB  1 
ATOM   893  C  CG  . ASN A 1 122 ? 34.45526 -21.55436 15.21319  1.000 32.62202 ? 122 ASN A CG  1 
ATOM   894  O  OD1 . ASN A 1 122 ? 33.44026 -22.07957 15.67010  1.000 27.88754 ? 122 ASN A OD1 1 
ATOM   895  N  ND2 . ASN A 1 122 ? 35.46560 -21.16320 15.98005  1.000 31.79082 ? 122 ASN A ND2 1 
ATOM   896  N  N   . CYS A 1 123 ? 31.68854 -23.28445 12.79750  1.000 18.73293 ? 123 CYS A N   1 
ATOM   897  C  CA  . CYS A 1 123 ? 30.23557 -23.24978 12.63740  1.000 19.94153 ? 123 CYS A CA  1 
ATOM   898  C  C   . CYS A 1 123 ? 29.60686 -24.11744 13.71944  1.000 17.33091 ? 123 CYS A C   1 
ATOM   899  O  O   . CYS A 1 123 ? 29.12462 -25.22388 13.44908  1.000 27.07103 ? 123 CYS A O   1 
ATOM   900  C  CB  . CYS A 1 123 ? 29.83416 -23.71904 11.23854  1.000 20.73655 ? 123 CYS A CB  1 
ATOM   901  S  SG  . CYS A 1 123 ? 30.70654 -22.85514 9.90818   1.000 13.98969 ? 123 CYS A SG  1 
ATOM   902  N  N   . PRO A 1 124 ? 29.59418 -23.63707 14.96594  1.000 21.01704 ? 124 PRO A N   1 
ATOM   903  C  CA  . PRO A 1 124 ? 29.12208 -24.48599 16.07315  1.000 21.93502 ? 124 PRO A CA  1 
ATOM   904  C  C   . PRO A 1 124 ? 27.66352 -24.89794 15.96290  1.000 23.92105 ? 124 PRO A C   1 
ATOM   905  O  O   . PRO A 1 124 ? 27.29230 -25.95393 16.48974  1.000 22.65834 ? 124 PRO A O   1 
ATOM   906  C  CB  . PRO A 1 124 ? 29.36770 -23.61031 17.31067  1.000 23.16786 ? 124 PRO A CB  1 
ATOM   907  C  CG  . PRO A 1 124 ? 29.39608 -22.21152 16.78875  1.000 27.93388 ? 124 PRO A CG  1 
ATOM   908  C  CD  . PRO A 1 124 ? 30.01295 -22.30295 15.42793  1.000 18.02503 ? 124 PRO A CD  1 
ATOM   909  N  N   . LYS A 1 125 ? 26.82350 -24.10901 15.29427  1.000 18.04695 ? 125 LYS A N   1 
ATOM   910  C  CA  . LYS A 1 125 ? 25.40121 -24.41500 15.21334  1.000 18.67627 ? 125 LYS A CA  1 
ATOM   911  C  C   . LYS A 1 125 ? 25.02475 -25.24008 13.98827  1.000 15.81439 ? 125 LYS A C   1 
ATOM   912  O  O   . LYS A 1 125 ? 23.86408 -25.65007 13.87451  1.000 19.17140 ? 125 LYS A O   1 
ATOM   913  C  CB  . LYS A 1 125 ? 24.57745 -23.12236 15.23239  1.000 15.36395 ? 125 LYS A CB  1 
ATOM   914  C  CG  . LYS A 1 125 ? 24.62463 -22.37246 16.55863  1.000 17.96535 ? 125 LYS A CG  1 
ATOM   915  C  CD  . LYS A 1 125 ? 24.23430 -23.26735 17.73083  1.000 16.75778 ? 125 LYS A CD  1 
ATOM   916  C  CE  . LYS A 1 125 ? 23.93372 -22.44934 18.98178  1.000 32.97443 ? 125 LYS A CE  1 
ATOM   917  N  NZ  . LYS A 1 125 ? 25.06966 -21.57370 19.37985  1.000 38.76909 ? 125 LYS A NZ  1 
ATOM   918  N  N   . GLY A 1 126 ? 25.95564 -25.49248 13.07825  1.000 17.90265 ? 126 GLY A N   1 
ATOM   919  C  CA  . GLY A 1 126 ? 25.71321 -26.35897 11.94314  1.000 15.88501 ? 126 GLY A CA  1 
ATOM   920  C  C   . GLY A 1 126 ? 25.99536 -25.67419 10.61916  1.000 15.39510 ? 126 GLY A C   1 
ATOM   921  O  O   . GLY A 1 126 ? 26.30713 -24.48605 10.54878  1.000 14.12713 ? 126 GLY A O   1 
ATOM   922  N  N   . VAL A 1 127 ? 25.86742 -26.46452 9.55204   1.000 14.77560 ? 127 VAL A N   1 
ATOM   923  C  CA  . VAL A 1 127 ? 26.22504 -26.04859 8.20065   1.000 10.10067 ? 127 VAL A CA  1 
ATOM   924  C  C   . VAL A 1 127 ? 25.06048 -26.33820 7.26134   1.000 15.47873 ? 127 VAL A C   1 
ATOM   925  O  O   . VAL A 1 127 ? 24.43012 -27.39845 7.34374   1.000 12.95104 ? 127 VAL A O   1 
ATOM   926  C  CB  . VAL A 1 127 ? 27.50681 -26.75783 7.70926   1.000 17.35483 ? 127 VAL A CB  1 
ATOM   927  C  CG1 . VAL A 1 127 ? 27.89553 -26.26282 6.32354   1.000 11.72139 ? 127 VAL A CG1 1 
ATOM   928  C  CG2 . VAL A 1 127 ? 28.65014 -26.54688 8.69415   1.000 20.18129 ? 127 VAL A CG2 1 
ATOM   929  N  N   . VAL A 1 128 ? 24.77925 -25.39145 6.36491   1.000 12.88097 ? 128 VAL A N   1 
ATOM   930  C  CA  . VAL A 1 128 ? 23.74735 -25.53191 5.34562   1.000 11.37130 ? 128 VAL A CA  1 
ATOM   931  C  C   . VAL A 1 128 ? 24.36628 -25.23411 3.98461   1.000 10.53246 ? 128 VAL A C   1 
ATOM   932  O  O   . VAL A 1 128 ? 25.30783 -24.44335 3.86942   1.000 13.97563 ? 128 VAL A O   1 
ATOM   933  C  CB  . VAL A 1 128 ? 22.54174 -24.59856 5.62071   1.000 10.85529 ? 128 VAL A CB  1 
ATOM   934  C  CG1 . VAL A 1 128 ? 21.40916 -24.86401 4.63893   1.000 10.60219 ? 128 VAL A CG1 1 
ATOM   935  C  CG2 . VAL A 1 128 ? 22.05144 -24.76110 7.05333   1.000 13.09990 ? 128 VAL A CG2 1 
ATOM   936  N  N   . ALA A 1 129 ? 23.84436 -25.89057 2.94907   1.000 9.70133  ? 129 ALA A N   1 
ATOM   937  C  CA  . ALA A 1 129 ? 24.24008 -25.63044 1.57078   1.000 15.47477 ? 129 ALA A CA  1 
ATOM   938  C  C   . ALA A 1 129 ? 22.99560 -25.36355 0.73604   1.000 14.89046 ? 129 ALA A C   1 
ATOM   939  O  O   . ALA A 1 129 ? 22.01215 -26.10634 0.82337   1.000 15.58975 ? 129 ALA A O   1 
ATOM   940  C  CB  . ALA A 1 129 ? 25.03474 -26.80162 0.98599   1.000 12.27727 ? 129 ALA A CB  1 
ATOM   941  N  N   . SER A 1 130 ? 23.04208 -24.30623 -0.07164  1.000 10.17571 ? 130 SER A N   1 
ATOM   942  C  CA  . SER A 1 130 ? 21.91013 -23.87355 -0.88437  1.000 13.79818 ? 130 SER A CA  1 
ATOM   943  C  C   . SER A 1 130 ? 22.29459 -23.95922 -2.35490  1.000 16.25928 ? 130 SER A C   1 
ATOM   944  O  O   . SER A 1 130 ? 23.22394 -23.27498 -2.79692  1.000 10.22293 ? 130 SER A O   1 
ATOM   945  C  CB  . SER A 1 130 ? 21.48794 -22.44842 -0.51863  1.000 11.78483 ? 130 SER A CB  1 
ATOM   946  O  OG  . SER A 1 130 ? 20.28630 -22.08726 -1.17045  1.000 18.08685 ? 130 SER A OG  1 
ATOM   947  N  N   . LEU A 1 131 ? 21.58086 -24.79332 -3.10877  1.000 11.17762 ? 131 LEU A N   1 
ATOM   948  C  CA  . LEU A 1 131 ? 21.86692 -25.03517 -4.52345  1.000 17.95970 ? 131 LEU A CA  1 
ATOM   949  C  C   . LEU A 1 131 ? 20.66268 -24.60831 -5.35858  1.000 14.88934 ? 131 LEU A C   1 
ATOM   950  O  O   . LEU A 1 131 ? 19.73808 -25.39253 -5.58714  1.000 11.22931 ? 131 LEU A O   1 
ATOM   951  C  CB  . LEU A 1 131 ? 22.21842 -26.50304 -4.77358  1.000 13.08084 ? 131 LEU A CB  1 
ATOM   952  C  CG  . LEU A 1 131 ? 23.60778 -26.95018 -4.31332  1.000 15.54751 ? 131 LEU A CG  1 
ATOM   953  C  CD1 . LEU A 1 131 ? 23.53810 -27.76232 -3.02841  1.000 21.06204 ? 131 LEU A CD1 1 
ATOM   954  C  CD2 . LEU A 1 131 ? 24.29710 -27.73376 -5.41647  1.000 21.49255 ? 131 LEU A CD2 1 
ATOM   955  N  N   . SER A 1 132 ? 20.68529 -23.36145 -5.82614  1.000 14.00563 ? 132 SER A N   1 
ATOM   956  C  CA  . SER A 1 132 ? 19.64343 -22.84758 -6.71503  1.000 15.23260 ? 132 SER A CA  1 
ATOM   957  C  C   . SER A 1 132 ? 20.07727 -23.05082 -8.16806  1.000 14.38906 ? 132 SER A C   1 
ATOM   958  O  O   . SER A 1 132 ? 20.37045 -22.11205 -8.91091  1.000 15.61833 ? 132 SER A O   1 
ATOM   959  C  CB  . SER A 1 132 ? 19.35858 -21.38314 -6.40799  1.000 16.46852 ? 132 SER A CB  1 
ATOM   960  O  OG  . SER A 1 132 ? 18.82713 -21.22553 -5.10443  1.000 17.43285 ? 132 SER A OG  1 
ATOM   961  N  N   . LEU A 1 133 ? 20.11670 -24.32039 -8.56416  1.000 13.20842 ? 133 LEU A N   1 
ATOM   962  C  CA  . LEU A 1 133 ? 20.56130 -24.70151 -9.89897  1.000 14.50687 ? 133 LEU A CA  1 
ATOM   963  C  C   . LEU A 1 133 ? 20.01265 -26.08785 -10.21437 1.000 19.98938 ? 133 LEU A C   1 
ATOM   964  O  O   . LEU A 1 133 ? 19.35077 -26.71903 -9.38642  1.000 15.82095 ? 133 LEU A O   1 
ATOM   965  C  CB  . LEU A 1 133 ? 22.09049 -24.65558 -10.00238 1.000 14.50164 ? 133 LEU A CB  1 
ATOM   966  C  CG  . LEU A 1 133 ? 22.93094 -25.39019 -8.95066  1.000 19.61617 ? 133 LEU A CG  1 
ATOM   967  C  CD1 . LEU A 1 133 ? 23.07824 -26.87691 -9.26498  1.000 13.52375 ? 133 LEU A CD1 1 
ATOM   968  C  CD2 . LEU A 1 133 ? 24.29611 -24.72931 -8.82007  1.000 22.23439 ? 133 LEU A CD2 1 
ATOM   969  N  N   . GLY A 1 134 ? 20.29963 -26.55907 -11.41458 1.000 17.88372 ? 134 GLY A N   1 
ATOM   970  C  CA  . GLY A 1 134 ? 19.88596 -27.88789 -11.82149 1.000 20.24955 ? 134 GLY A CA  1 
ATOM   971  C  C   . GLY A 1 134 ? 19.75775 -27.98319 -13.32544 1.000 24.02848 ? 134 GLY A C   1 
ATOM   972  O  O   . GLY A 1 134 ? 19.80701 -26.99003 -14.05056 1.000 22.86057 ? 134 GLY A O   1 
ATOM   973  N  N   . GLY A 1 135 ? 19.59465 -29.21089 -13.78469 1.000 20.65014 ? 135 GLY A N   1 
ATOM   974  C  CA  . GLY A 1 135 ? 19.40416 -29.48751 -15.19490 1.000 20.51987 ? 135 GLY A CA  1 
ATOM   975  C  C   . GLY A 1 135 ? 18.78653 -30.85370 -15.38132 1.000 15.68152 ? 135 GLY A C   1 
ATOM   976  O  O   . GLY A 1 135 ? 18.04620 -31.33829 -14.52334 1.000 16.68883 ? 135 GLY A O   1 
ATOM   977  N  N   . GLY A 1 136 ? 19.09836 -31.48390 -16.51401 1.000 15.51333 ? 136 GLY A N   1 
ATOM   978  C  CA  . GLY A 1 136 ? 18.58482 -32.80973 -16.78579 1.000 18.69524 ? 136 GLY A CA  1 
ATOM   979  C  C   . GLY A 1 136 ? 19.07808 -33.84289 -15.79065 1.000 16.87306 ? 136 GLY A C   1 
ATOM   980  O  O   . GLY A 1 136 ? 20.03046 -33.62870 -15.03917 1.000 20.99574 ? 136 GLY A O   1 
ATOM   981  N  N   . TYR A 1 137 ? 18.40943 -34.99577 -15.79407 1.000 17.38855 ? 137 TYR A N   1 
ATOM   982  C  CA  . TYR A 1 137 ? 18.72947 -36.04102 -14.83100 1.000 16.49530 ? 137 TYR A CA  1 
ATOM   983  C  C   . TYR A 1 137 ? 20.15337 -36.54686 -15.02519 1.000 14.47259 ? 137 TYR A C   1 
ATOM   984  O  O   . TYR A 1 137 ? 20.61977 -36.73900 -16.15257 1.000 13.98558 ? 137 TYR A O   1 
ATOM   985  C  CB  . TYR A 1 137 ? 17.74420 -37.20565 -14.94656 1.000 16.49213 ? 137 TYR A CB  1 
ATOM   986  C  CG  . TYR A 1 137 ? 18.06516 -38.34797 -14.00488 1.000 15.52797 ? 137 TYR A CG  1 
ATOM   987  C  CD1 . TYR A 1 137 ? 17.65214 -38.31735 -12.67882 1.000 19.66370 ? 137 TYR A CD1 1 
ATOM   988  C  CD2 . TYR A 1 137 ? 18.78980 -39.45240 -14.43970 1.000 17.61027 ? 137 TYR A CD2 1 
ATOM   989  C  CE1 . TYR A 1 137 ? 17.94885 -39.35627 -11.81156 1.000 17.38692 ? 137 TYR A CE1 1 
ATOM   990  C  CE2 . TYR A 1 137 ? 19.09241 -40.49419 -13.58082 1.000 12.85853 ? 137 TYR A CE2 1 
ATOM   991  C  CZ  . TYR A 1 137 ? 18.66739 -40.44263 -12.26754 1.000 17.90449 ? 137 TYR A CZ  1 
ATOM   992  O  OH  . TYR A 1 137 ? 18.96258 -41.47634 -11.40499 1.000 21.47316 ? 137 TYR A OH  1 
ATOM   993  N  N   . SER A 1 138 ? 20.83698 -36.76934 -13.90511 1.000 15.19424 ? 138 SER A N   1 
ATOM   994  C  CA  . SER A 1 138 ? 22.19768 -37.29235 -13.90391 1.000 11.83224 ? 138 SER A CA  1 
ATOM   995  C  C   . SER A 1 138 ? 22.42927 -38.00246 -12.58059 1.000 15.79681 ? 138 SER A C   1 
ATOM   996  O  O   . SER A 1 138 ? 22.31710 -37.38303 -11.51857 1.000 16.00248 ? 138 SER A O   1 
ATOM   997  C  CB  . SER A 1 138 ? 23.21803 -36.17043 -14.10628 1.000 18.02204 ? 138 SER A CB  1 
ATOM   998  O  OG  . SER A 1 138 ? 24.52205 -36.60109 -13.76717 1.000 21.20824 ? 138 SER A OG  1 
ATOM   999  N  N   . SER A 1 139 ? 22.74257 -39.29888 -12.64390 1.000 15.71888 ? 139 SER A N   1 
ATOM   1000 C  CA  . SER A 1 139 ? 22.98076 -40.05647 -11.41959 1.000 16.88081 ? 139 SER A CA  1 
ATOM   1001 C  C   . SER A 1 139 ? 24.21305 -39.55045 -10.68322 1.000 16.29555 ? 139 SER A C   1 
ATOM   1002 O  O   . SER A 1 139 ? 24.27174 -39.61484 -9.45006  1.000 14.04382 ? 139 SER A O   1 
ATOM   1003 C  CB  . SER A 1 139 ? 23.13378 -41.54363 -11.73877 1.000 14.65893 ? 139 SER A CB  1 
ATOM   1004 O  OG  . SER A 1 139 ? 24.36827 -41.79217 -12.38975 1.000 23.58983 ? 139 SER A OG  1 
ATOM   1005 N  N   . SER A 1 140 ? 25.20450 -39.04537 -11.41972 1.000 15.66024 ? 140 SER A N   1 
ATOM   1006 C  CA  . SER A 1 140 ? 26.42201 -38.54856 -10.78767 1.000 17.34730 ? 140 SER A CA  1 
ATOM   1007 C  C   . SER A 1 140 ? 26.15639 -37.27381 -9.99547  1.000 15.16282 ? 140 SER A C   1 
ATOM   1008 O  O   . SER A 1 140 ? 26.75089 -37.06343 -8.93186  1.000 17.18564 ? 140 SER A O   1 
ATOM   1009 C  CB  . SER A 1 140 ? 27.50080 -38.31195 -11.84493 1.000 20.15068 ? 140 SER A CB  1 
ATOM   1010 O  OG  . SER A 1 140 ? 27.83374 -39.51783 -12.51018 1.000 35.00248 ? 140 SER A OG  1 
ATOM   1011 N  N   . VAL A 1 141 ? 25.26934 -36.41055 -10.49449 1.000 13.44795 ? 141 VAL A N   1 
ATOM   1012 C  CA  . VAL A 1 141 ? 24.94272 -35.18894 -9.76563  1.000 17.06888 ? 141 VAL A CA  1 
ATOM   1013 C  C   . VAL A 1 141 ? 24.10015 -35.51133 -8.53727  1.000 15.36913 ? 141 VAL A C   1 
ATOM   1014 O  O   . VAL A 1 141 ? 24.30590 -34.93802 -7.45984  1.000 14.26237 ? 141 VAL A O   1 
ATOM   1015 C  CB  . VAL A 1 141 ? 24.24054 -34.18340 -10.69635 1.000 17.36351 ? 141 VAL A CB  1 
ATOM   1016 C  CG1 . VAL A 1 141 ? 23.76202 -32.97213 -9.91062  1.000 16.83761 ? 141 VAL A CG1 1 
ATOM   1017 C  CG2 . VAL A 1 141 ? 25.18142 -33.75215 -11.80983 1.000 17.23582 ? 141 VAL A CG2 1 
ATOM   1018 N  N   . ASN A 1 142 ? 23.14016 -36.43183 -8.67753  1.000 11.89112 ? 142 ASN A N   1 
ATOM   1019 C  CA  . ASN A 1 142 ? 22.37741 -36.89040 -7.52065  1.000 14.99754 ? 142 ASN A CA  1 
ATOM   1020 C  C   . ASN A 1 142 ? 23.29501 -37.48177 -6.45918  1.000 15.40226 ? 142 ASN A C   1 
ATOM   1021 O  O   . ASN A 1 142 ? 23.11831 -37.22583 -5.26244  1.000 16.64077 ? 142 ASN A O   1 
ATOM   1022 C  CB  . ASN A 1 142 ? 21.33282 -37.92239 -7.95161  1.000 14.08026 ? 142 ASN A CB  1 
ATOM   1023 C  CG  . ASN A 1 142 ? 20.17059 -37.30492 -8.70348  1.000 17.69627 ? 142 ASN A CG  1 
ATOM   1024 O  OD1 . ASN A 1 142 ? 20.22566 -36.14756 -9.11407  1.000 14.93877 ? 142 ASN A OD1 1 
ATOM   1025 N  ND2 . ASN A 1 142 ? 19.10638 -38.08017 -8.88661  1.000 16.35645 ? 142 ASN A ND2 1 
ATOM   1026 N  N   . SER A 1 143 ? 24.28372 -38.27431 -6.88166  1.000 11.62399 ? 143 SER A N   1 
ATOM   1027 C  CA  . SER A 1 143 ? 25.19025 -38.91178 -5.93205  1.000 13.17792 ? 143 SER A CA  1 
ATOM   1028 C  C   . SER A 1 143 ? 26.02125 -37.88257 -5.17560  1.000 16.25451 ? 143 SER A C   1 
ATOM   1029 O  O   . SER A 1 143 ? 26.27576 -38.04381 -3.97557  1.000 17.52361 ? 143 SER A O   1 
ATOM   1030 C  CB  . SER A 1 143 ? 26.10052 -39.90113 -6.66156  1.000 14.76004 ? 143 SER A CB  1 
ATOM   1031 O  OG  . SER A 1 143 ? 27.03876 -40.47985 -5.76580  1.000 22.24453 ? 143 SER A OG  1 
ATOM   1032 N  N   . ALA A 1 144 ? 26.45875 -36.82278 -5.86055  1.000 8.35763  ? 144 ALA A N   1 
ATOM   1033 C  CA  . ALA A 1 144 ? 27.26550 -35.80166 -5.20085  1.000 14.10632 ? 144 ALA A CA  1 
ATOM   1034 C  C   . ALA A 1 144 ? 26.45385 -35.05410 -4.15149  1.000 14.34060 ? 144 ALA A C   1 
ATOM   1035 O  O   . ALA A 1 144 ? 26.96796 -34.72274 -3.07665  1.000 13.08281 ? 144 ALA A O   1 
ATOM   1036 C  CB  . ALA A 1 144 ? 27.83592 -34.83160 -6.23521  1.000 10.51766 ? 144 ALA A CB  1 
ATOM   1037 N  N   . ALA A 1 145 ? 25.18107 -34.78106 -4.44575  1.000 12.15974 ? 145 ALA A N   1 
ATOM   1038 C  CA  . ALA A 1 145 ? 24.31774 -34.12838 -3.46805  1.000 14.93752 ? 145 ALA A CA  1 
ATOM   1039 C  C   . ALA A 1 145 ? 24.05424 -35.03532 -2.27332  1.000 13.03943 ? 145 ALA A C   1 
ATOM   1040 O  O   . ALA A 1 145 ? 23.97744 -34.56191 -1.13369  1.000 14.05372 ? 145 ALA A O   1 
ATOM   1041 C  CB  . ALA A 1 145 ? 23.00430 -33.70893 -4.12665  1.000 10.68881 ? 145 ALA A CB  1 
ATOM   1042 N  N   . ALA A 1 146 ? 23.90831 -36.34112 -2.51270  1.000 13.34727 ? 146 ALA A N   1 
ATOM   1043 C  CA  . ALA A 1 146 ? 23.71851 -37.27283 -1.40595  1.000 12.47414 ? 146 ALA A CA  1 
ATOM   1044 C  C   . ALA A 1 146 ? 24.97176 -37.36447 -0.54292  1.000 14.58166 ? 146 ALA A C   1 
ATOM   1045 O  O   . ALA A 1 146 ? 24.87866 -37.51401 0.68137   1.000 16.76794 ? 146 ALA A O   1 
ATOM   1046 C  CB  . ALA A 1 146 ? 23.32361 -38.65106 -1.93707  1.000 13.90023 ? 146 ALA A CB  1 
ATOM   1047 N  N   . ARG A 1 147 ? 26.15309 -37.27373 -1.16030  1.000 12.28580 ? 147 ARG A N   1 
ATOM   1048 C  CA  . ARG A 1 147 ? 27.39281 -37.28566 -0.38835  1.000 11.89514 ? 147 ARG A CA  1 
ATOM   1049 C  C   . ARG A 1 147 ? 27.47358 -36.07633 0.53491   1.000 14.19795 ? 147 ARG A C   1 
ATOM   1050 O  O   . ARG A 1 147 ? 27.79411 -36.20574 1.72253   1.000 11.72878 ? 147 ARG A O   1 
ATOM   1051 C  CB  . ARG A 1 147 ? 28.60224 -37.32263 -1.32404  1.000 16.24068 ? 147 ARG A CB  1 
ATOM   1052 C  CG  . ARG A 1 147 ? 28.83727 -38.66029 -2.00132  1.000 14.44773 ? 147 ARG A CG  1 
ATOM   1053 C  CD  . ARG A 1 147 ? 30.25540 -38.75748 -2.54702  1.000 16.91647 ? 147 ARG A CD  1 
ATOM   1054 N  NE  . ARG A 1 147 ? 30.54116 -37.73123 -3.54275  1.000 16.78629 ? 147 ARG A NE  1 
ATOM   1055 C  CZ  . ARG A 1 147 ? 30.30289 -37.86332 -4.84033  1.000 18.65047 ? 147 ARG A CZ  1 
ATOM   1056 N  NH1 . ARG A 1 147 ? 29.76668 -38.96663 -5.33473  1.000 15.81547 ? 147 ARG A NH1 1 
ATOM   1057 N  NH2 . ARG A 1 147 ? 30.60885 -36.86320 -5.66214  1.000 13.66315 ? 147 ARG A NH2 1 
ATOM   1058 N  N   . LEU A 1 148 ? 27.18415 -34.88768 -0.00073  1.000 13.56041 ? 148 LEU A N   1 
ATOM   1059 C  CA  . LEU A 1 148 ? 27.23367 -33.66761 0.79931   1.000 13.68182 ? 148 LEU A CA  1 
ATOM   1060 C  C   . LEU A 1 148 ? 26.26972 -33.74294 1.97787   1.000 12.27600 ? 148 LEU A C   1 
ATOM   1061 O  O   . LEU A 1 148 ? 26.61833 -33.37401 3.10536   1.000 19.70619 ? 148 LEU A O   1 
ATOM   1062 C  CB  . LEU A 1 148 ? 26.92120 -32.45888 -0.08443  1.000 10.61703 ? 148 LEU A CB  1 
ATOM   1063 C  CG  . LEU A 1 148 ? 26.91762 -31.08878 0.59451   1.000 12.13152 ? 148 LEU A CG  1 
ATOM   1064 C  CD1 . LEU A 1 148 ? 28.26954 -30.81096 1.22650   1.000 12.59800 ? 148 LEU A CD1 1 
ATOM   1065 C  CD2 . LEU A 1 148 ? 26.54718 -29.99691 -0.40052  1.000 13.26514 ? 148 LEU A CD2 1 
ATOM   1066 N  N   . GLN A 1 149 ? 25.04666 -34.21931 1.73244   1.000 9.81029  ? 149 GLN A N   1 
ATOM   1067 C  CA  . GLN A 1 149 ? 24.09204 -34.40820 2.81989   1.000 15.88315 ? 149 GLN A CA  1 
ATOM   1068 C  C   . GLN A 1 149 ? 24.60684 -35.42486 3.83149   1.000 18.55017 ? 149 GLN A C   1 
ATOM   1069 O  O   . GLN A 1 149 ? 24.45867 -35.23812 5.04525   1.000 17.94920 ? 149 GLN A O   1 
ATOM   1070 C  CB  . GLN A 1 149 ? 22.74129 -34.84914 2.25683   1.000 13.80498 ? 149 GLN A CB  1 
ATOM   1071 C  CG  . GLN A 1 149 ? 21.69345 -35.14614 3.31584   1.000 18.71576 ? 149 GLN A CG  1 
ATOM   1072 C  CD  . GLN A 1 149 ? 21.16805 -33.89456 3.98869   1.000 14.91453 ? 149 GLN A CD  1 
ATOM   1073 O  OE1 . GLN A 1 149 ? 20.96541 -32.86655 3.34231   1.000 11.68255 ? 149 GLN A OE1 1 
ATOM   1074 N  NE2 . GLN A 1 149 ? 20.94233 -33.97567 5.29466   1.000 16.58574 ? 149 GLN A NE2 1 
ATOM   1075 N  N   . SER A 1 150 ? 25.21824 -36.50842 3.34836   1.000 15.48972 ? 150 SER A N   1 
ATOM   1076 C  CA  . SER A 1 150 ? 25.72905 -37.53770 4.24736   1.000 18.67804 ? 150 SER A CA  1 
ATOM   1077 C  C   . SER A 1 150 ? 26.88569 -37.02879 5.09772   1.000 16.18601 ? 150 SER A C   1 
ATOM   1078 O  O   . SER A 1 150 ? 27.07761 -37.49996 6.22473   1.000 14.50890 ? 150 SER A O   1 
ATOM   1079 C  CB  . SER A 1 150 ? 26.16433 -38.76381 3.44613   1.000 17.45498 ? 150 SER A CB  1 
ATOM   1080 O  OG  . SER A 1 150 ? 26.86678 -39.68013 4.26783   1.000 27.03811 ? 150 SER A OG  1 
ATOM   1081 N  N   . SER A 1 151 ? 27.66184 -36.07214 4.58552   1.000 12.88666 ? 151 SER A N   1 
ATOM   1082 C  CA  . SER A 1 151 ? 28.80455 -35.56020 5.33281   1.000 18.61886 ? 151 SER A CA  1 
ATOM   1083 C  C   . SER A 1 151 ? 28.39938 -34.69297 6.51885   1.000 17.40788 ? 151 SER A C   1 
ATOM   1084 O  O   . SER A 1 151 ? 29.27368 -34.29279 7.29604   1.000 16.88885 ? 151 SER A O   1 
ATOM   1085 C  CB  . SER A 1 151 ? 29.72684 -34.76265 4.40780   1.000 21.18921 ? 151 SER A CB  1 
ATOM   1086 O  OG  . SER A 1 151 ? 29.18503 -33.48448 4.12494   1.000 15.11790 ? 151 SER A OG  1 
ATOM   1087 N  N   . GLY A 1 152 ? 27.11703 -34.39740 6.67663   1.000 12.01460 ? 152 GLY A N   1 
ATOM   1088 C  CA  . GLY A 1 152 ? 26.63037 -33.58013 7.76223   1.000 15.17911 ? 152 GLY A CA  1 
ATOM   1089 C  C   . GLY A 1 152 ? 26.14932 -32.18743 7.38373   1.000 19.23404 ? 152 GLY A C   1 
ATOM   1090 O  O   . GLY A 1 152 ? 26.07751 -31.32095 8.26520   1.000 23.66393 ? 152 GLY A O   1 
ATOM   1091 N  N   . VAL A 1 153 ? 25.82171 -31.94761 6.11704   1.000 15.38269 ? 153 VAL A N   1 
ATOM   1092 C  CA  . VAL A 1 153 ? 25.37066 -30.64501 5.64257   1.000 12.30419 ? 153 VAL A CA  1 
ATOM   1093 C  C   . VAL A 1 153 ? 23.90932 -30.75370 5.23416   1.000 17.33092 ? 153 VAL A C   1 
ATOM   1094 O  O   . VAL A 1 153 ? 23.51174 -31.71314 4.56298   1.000 19.48569 ? 153 VAL A O   1 
ATOM   1095 C  CB  . VAL A 1 153 ? 26.23010 -30.14146 4.46558   1.000 15.98729 ? 153 VAL A CB  1 
ATOM   1096 C  CG1 . VAL A 1 153 ? 25.67487 -28.83705 3.92179   1.000 14.13993 ? 153 VAL A CG1 1 
ATOM   1097 C  CG2 . VAL A 1 153 ? 27.67421 -29.96649 4.89901   1.000 11.86687 ? 153 VAL A CG2 1 
ATOM   1098 N  N   . MET A 1 154 ? 23.10987 -29.77205 5.64770   1.000 14.54328 ? 154 MET A N   1 
ATOM   1099 C  CA  . MET A 1 154 ? 21.71146 -29.68349 5.24086   1.000 13.94703 ? 154 MET A CA  1 
ATOM   1100 C  C   . MET A 1 154 ? 21.66275 -29.12173 3.82473   1.000 15.82806 ? 154 MET A C   1 
ATOM   1101 O  O   . MET A 1 154 ? 21.97106 -27.94598 3.60408   1.000 11.86899 ? 154 MET A O   1 
ATOM   1102 C  CB  . MET A 1 154 ? 20.93018 -28.81078 6.21969   1.000 12.74899 ? 154 MET A CB  1 
ATOM   1103 C  CG  . MET A 1 154 ? 19.41395 -28.95082 6.13992   1.000 17.47407 ? 154 MET A CG  1 
ATOM   1104 S  SD  . MET A 1 154 ? 18.65234 -28.06821 4.76187   1.000 19.87576 ? 154 MET A SD  1 
ATOM   1105 C  CE  . MET A 1 154 ? 16.91121 -28.20616 5.17813   1.000 17.33029 ? 154 MET A CE  1 
ATOM   1106 N  N   . VAL A 1 155 ? 21.28415 -29.95899 2.86425   1.000 16.60605 ? 155 VAL A N   1 
ATOM   1107 C  CA  . VAL A 1 155 ? 21.31294 -29.60481 1.45036   1.000 14.95891 ? 155 VAL A CA  1 
ATOM   1108 C  C   . VAL A 1 155 ? 19.90344 -29.24509 1.00762   1.000 14.84217 ? 155 VAL A C   1 
ATOM   1109 O  O   . VAL A 1 155 ? 18.97152 -30.04681 1.15135   1.000 15.43866 ? 155 VAL A O   1 
ATOM   1110 C  CB  . VAL A 1 155 ? 21.88145 -30.74915 0.59764   1.000 11.20307 ? 155 VAL A CB  1 
ATOM   1111 C  CG1 . VAL A 1 155 ? 21.92876 -30.34849 -0.86711  1.000 14.27447 ? 155 VAL A CG1 1 
ATOM   1112 C  CG2 . VAL A 1 155 ? 23.26227 -31.13911 1.09191   1.000 14.39631 ? 155 VAL A CG2 1 
ATOM   1113 N  N   . ALA A 1 156 ? 19.74956 -28.04032 0.46654   1.000 10.62420 ? 156 ALA A N   1 
ATOM   1114 C  CA  . ALA A 1 156 ? 18.49941 -27.59322 -0.12944  1.000 11.92138 ? 156 ALA A CA  1 
ATOM   1115 C  C   . ALA A 1 156 ? 18.74763 -27.29756 -1.59982  1.000 9.94226  ? 156 ALA A C   1 
ATOM   1116 O  O   . ALA A 1 156 ? 19.72751 -26.62663 -1.94319  1.000 13.47856 ? 156 ALA A O   1 
ATOM   1117 C  CB  . ALA A 1 156 ? 17.95463 -26.35621 0.58747   1.000 12.73311 ? 156 ALA A CB  1 
ATOM   1118 N  N   . VAL A 1 157 ? 17.87860 -27.81673 -2.46617  1.000 11.69706 ? 157 VAL A N   1 
ATOM   1119 C  CA  . VAL A 1 157 ? 18.04271 -27.66154 -3.90506  1.000 10.39936 ? 157 VAL A CA  1 
ATOM   1120 C  C   . VAL A 1 157 ? 16.72126 -27.21694 -4.51491  1.000 16.88014 ? 157 VAL A C   1 
ATOM   1121 O  O   . VAL A 1 157 ? 15.64135 -27.49707 -3.98510  1.000 12.31601 ? 157 VAL A O   1 
ATOM   1122 C  CB  . VAL A 1 157 ? 18.54659 -28.96092 -4.57774  1.000 12.84599 ? 157 VAL A CB  1 
ATOM   1123 C  CG1 . VAL A 1 157 ? 19.83035 -29.44994 -3.91024  1.000 17.64098 ? 157 VAL A CG1 1 
ATOM   1124 C  CG2 . VAL A 1 157 ? 17.47173 -30.03567 -4.54095  1.000 15.24514 ? 157 VAL A CG2 1 
ATOM   1125 N  N   . ALA A 1 158 ? 16.81770 -26.51091 -5.63841  1.000 13.06816 ? 158 ALA A N   1 
ATOM   1126 C  CA  . ALA A 1 158 ? 15.63051 -26.03125 -6.32888  1.000 14.97299 ? 158 ALA A CA  1 
ATOM   1127 C  C   . ALA A 1 158 ? 14.96648 -27.16487 -7.10116  1.000 13.68932 ? 158 ALA A C   1 
ATOM   1128 O  O   . ALA A 1 158 ? 15.62880 -28.08065 -7.59650  1.000 13.57155 ? 158 ALA A O   1 
ATOM   1129 C  CB  . ALA A 1 158 ? 15.98927 -24.88761 -7.27768  1.000 10.36702 ? 158 ALA A CB  1 
ATOM   1130 N  N   . ALA A 1 159 ? 13.63668 -27.09694 -7.19980  1.000 13.82493 ? 159 ALA A N   1 
ATOM   1131 C  CA  . ALA A 1 159 ? 12.89718 -28.14405 -7.89298  1.000 18.43886 ? 159 ALA A CA  1 
ATOM   1132 C  C   . ALA A 1 159 ? 12.95800 -27.98418 -9.40496  1.000 15.58735 ? 159 ALA A C   1 
ATOM   1133 O  O   . ALA A 1 159 ? 12.82175 -28.97332 -10.13224 1.000 12.32861 ? 159 ALA A O   1 
ATOM   1134 C  CB  . ALA A 1 159 ? 11.44134 -28.15809 -7.42959  1.000 11.21195 ? 159 ALA A CB  1 
ATOM   1135 N  N   . GLY A 1 160 ? 13.15535 -26.76979 -9.89244  1.000 16.64369 ? 160 GLY A N   1 
ATOM   1136 C  CA  . GLY A 1 160 ? 13.17067 -26.51145 -11.31514 1.000 15.76985 ? 160 GLY A CA  1 
ATOM   1137 C  C   . GLY A 1 160 ? 11.99603 -25.64554 -11.74878 1.000 17.34908 ? 160 GLY A C   1 
ATOM   1138 O  O   . GLY A 1 160 ? 10.94201 -25.59638 -11.10783 1.000 13.20593 ? 160 GLY A O   1 
ATOM   1139 N  N   . ASN A 1 161 ? 12.19107 -24.96013 -12.87272 1.000 13.41161 ? 161 ASN A N   1 
ATOM   1140 C  CA  . ASN A 1 161 ? 11.22355 -24.00742 -13.40587 1.000 17.98616 ? 161 ASN A CA  1 
ATOM   1141 C  C   . ASN A 1 161 ? 10.64388 -24.48172 -14.73433 1.000 17.06570 ? 161 ASN A C   1 
ATOM   1142 O  O   . ASN A 1 161 ? 10.52809 -23.70999 -15.68731 1.000 15.80706 ? 161 ASN A O   1 
ATOM   1143 C  CB  . ASN A 1 161 ? 11.85841 -22.62917 -13.57432 1.000 14.42267 ? 161 ASN A CB  1 
ATOM   1144 C  CG  . ASN A 1 161 ? 12.52307 -22.13158 -12.30534 1.000 20.93991 ? 161 ASN A CG  1 
ATOM   1145 O  OD1 . ASN A 1 161 ? 12.07146 -22.42248 -11.19887 1.000 21.91014 ? 161 ASN A OD1 1 
ATOM   1146 N  ND2 . ASN A 1 161 ? 13.60008 -21.37167 -12.46107 1.000 23.83600 ? 161 ASN A ND2 1 
ATOM   1147 N  N   . ASN A 1 162 ? 10.26294 -25.75523 -14.81192 1.000 17.21592 ? 162 ASN A N   1 
ATOM   1148 C  CA  . ASN A 1 162 ? 9.76286  -26.33341 -16.05139 1.000 17.11972 ? 162 ASN A CA  1 
ATOM   1149 C  C   . ASN A 1 162 ? 8.26633  -26.61611 -16.03383 1.000 22.76039 ? 162 ASN A C   1 
ATOM   1150 O  O   . ASN A 1 162 ? 7.71360  -26.98566 -17.07580 1.000 20.28165 ? 162 ASN A O   1 
ATOM   1151 C  CB  . ASN A 1 162 ? 10.52006 -27.62798 -16.37274 1.000 18.88672 ? 162 ASN A CB  1 
ATOM   1152 C  CG  . ASN A 1 162 ? 12.02473 -27.44021 -16.37363 1.000 28.13850 ? 162 ASN A CG  1 
ATOM   1153 O  OD1 . ASN A 1 162 ? 12.69315 -27.70654 -15.37472 1.000 27.80506 ? 162 ASN A OD1 1 
ATOM   1154 N  ND2 . ASN A 1 162 ? 12.56693 -26.98475 -17.49863 1.000 28.97149 ? 162 ASN A ND2 1 
ATOM   1155 N  N   . ASN A 1 163 ? 7.59802  -26.44758 -14.89246 1.000 17.38031 ? 163 ASN A N   1 
ATOM   1156 C  CA  . ASN A 1 163 ? 6.19957  -26.84760 -14.72645 1.000 21.17659 ? 163 ASN A CA  1 
ATOM   1157 C  C   . ASN A 1 163 ? 6.01136  -28.31050 -15.12536 1.000 21.40226 ? 163 ASN A C   1 
ATOM   1158 O  O   . ASN A 1 163 ? 5.13327  -28.66971 -15.91413 1.000 16.26878 ? 163 ASN A O   1 
ATOM   1159 C  CB  . ASN A 1 163 ? 5.26246  -25.93198 -15.51548 1.000 18.11615 ? 163 ASN A CB  1 
ATOM   1160 C  CG  . ASN A 1 163 ? 3.80040  -26.18559 -15.20237 1.000 15.60504 ? 163 ASN A CG  1 
ATOM   1161 O  OD1 . ASN A 1 163 ? 3.45031  -26.57737 -14.08901 1.000 15.88032 ? 163 ASN A OD1 1 
ATOM   1162 N  ND2 . ASN A 1 163 ? 2.94025  -25.97797 -16.19083 1.000 23.32420 ? 163 ASN A ND2 1 
ATOM   1163 N  N   . ALA A 1 164 ? 6.86817  -29.16254 -14.57164 1.000 17.45900 ? 164 ALA A N   1 
ATOM   1164 C  CA  . ALA A 1 164 ? 6.87035  -30.58180 -14.88105 1.000 20.06848 ? 164 ALA A CA  1 
ATOM   1165 C  C   . ALA A 1 164 ? 7.24218  -31.35069 -13.62187 1.000 19.78798 ? 164 ALA A C   1 
ATOM   1166 O  O   . ALA A 1 164 ? 7.49289  -30.76802 -12.56284 1.000 19.66275 ? 164 ALA A O   1 
ATOM   1167 C  CB  . ALA A 1 164 ? 7.83241  -30.89334 -16.03361 1.000 19.68706 ? 164 ALA A CB  1 
ATOM   1168 N  N   . ASP A 1 165 ? 7.27002  -32.67382 -13.73738 1.000 20.36668 ? 165 ASP A N   1 
ATOM   1169 C  CA  . ASP A 1 165 ? 7.67222  -33.50681 -12.61438 1.000 24.75033 ? 165 ASP A CA  1 
ATOM   1170 C  C   . ASP A 1 165 ? 9.17581  -33.38477 -12.40125 1.000 20.41339 ? 165 ASP A C   1 
ATOM   1171 O  O   . ASP A 1 165 ? 9.96054  -33.53119 -13.34221 1.000 20.42958 ? 165 ASP A O   1 
ATOM   1172 C  CB  . ASP A 1 165 ? 7.27633  -34.96117 -12.86663 1.000 27.96617 ? 165 ASP A CB  1 
ATOM   1173 C  CG  . ASP A 1 165 ? 7.36979  -35.81893 -11.61867 1.000 24.23015 ? 165 ASP A CG  1 
ATOM   1174 O  OD1 . ASP A 1 165 ? 8.39633  -35.74665 -10.91182 1.000 18.48293 ? 165 ASP A OD1 1 
ATOM   1175 O  OD2 . ASP A 1 165 ? 6.40963  -36.56535 -11.33889 1.000 23.53433 ? 165 ASP A OD2 1 
ATOM   1176 N  N   . ALA A 1 166 ? 9.57872  -33.11508 -11.15962 1.000 17.66239 ? 166 ALA A N   1 
ATOM   1177 C  CA  . ALA A 1 166 ? 10.99184 -32.92448 -10.85336 1.000 18.44303 ? 166 ALA A CA  1 
ATOM   1178 C  C   . ALA A 1 166 ? 11.79613 -34.21745 -10.89520 1.000 17.41577 ? 166 ALA A C   1 
ATOM   1179 O  O   . ALA A 1 166 ? 13.01266 -34.16923 -10.68071 1.000 19.00542 ? 166 ALA A O   1 
ATOM   1180 C  CB  . ALA A 1 166 ? 11.14598 -32.26721 -9.48101  1.000 15.40872 ? 166 ALA A CB  1 
ATOM   1181 N  N   . ARG A 1 167 ? 11.16357 -35.36108 -11.17015 1.000 15.93483 ? 167 ARG A N   1 
ATOM   1182 C  CA  . ARG A 1 167 ? 11.88527 -36.62843 -11.19198 1.000 19.79550 ? 167 ARG A CA  1 
ATOM   1183 C  C   . ARG A 1 167 ? 12.85564 -36.73094 -12.36214 1.000 19.30398 ? 167 ARG A C   1 
ATOM   1184 O  O   . ARG A 1 167 ? 13.73726 -37.59676 -12.34421 1.000 16.88967 ? 167 ARG A O   1 
ATOM   1185 C  CB  . ARG A 1 167 ? 10.89757 -37.79555 -11.23565 1.000 20.73666 ? 167 ARG A CB  1 
ATOM   1186 N  N   . ASN A 1 168 ? 12.71658 -35.87582 -13.37514 1.000 17.80082 ? 168 ASN A N   1 
ATOM   1187 C  CA  . ASN A 1 168 ? 13.59995 -35.88499 -14.53270 1.000 16.78541 ? 168 ASN A CA  1 
ATOM   1188 C  C   . ASN A 1 168 ? 14.65585 -34.78731 -14.46991 1.000 18.68124 ? 168 ASN A C   1 
ATOM   1189 O  O   . ASN A 1 168 ? 15.21224 -34.41159 -15.50768 1.000 19.01847 ? 168 ASN A O   1 
ATOM   1190 C  CB  . ASN A 1 168 ? 12.78592 -35.75779 -15.82113 1.000 19.02799 ? 168 ASN A CB  1 
ATOM   1191 C  CG  . ASN A 1 168 ? 11.97435 -37.00151 -16.12337 1.000 22.56183 ? 168 ASN A CG  1 
ATOM   1192 O  OD1 . ASN A 1 168 ? 12.41020 -38.12096 -15.85500 1.000 21.34694 ? 168 ASN A OD1 1 
ATOM   1193 N  ND2 . ASN A 1 168 ? 10.78769 -36.81170 -16.68836 1.000 21.09997 ? 168 ASN A ND2 1 
ATOM   1194 N  N   . TYR A 1 169 ? 14.94766 -34.27007 -13.27781 1.000 17.32503 ? 169 TYR A N   1 
ATOM   1195 C  CA  . TYR A 1 169 ? 15.89647 -33.17817 -13.12827 1.000 16.56754 ? 169 TYR A CA  1 
ATOM   1196 C  C   . TYR A 1 169 ? 16.79090 -33.42752 -11.92304 1.000 15.29287 ? 169 TYR A C   1 
ATOM   1197 O  O   . TYR A 1 169 ? 16.36000 -33.98321 -10.90993 1.000 16.20874 ? 169 TYR A O   1 
ATOM   1198 C  CB  . TYR A 1 169 ? 15.17679 -31.83093 -12.98952 1.000 13.86564 ? 169 TYR A CB  1 
ATOM   1199 C  CG  . TYR A 1 169 ? 14.32053 -31.48791 -14.18748 1.000 17.12171 ? 169 TYR A CG  1 
ATOM   1200 C  CD1 . TYR A 1 169 ? 12.98235 -31.84999 -14.23436 1.000 14.15259 ? 169 TYR A CD1 1 
ATOM   1201 C  CD2 . TYR A 1 169 ? 14.85396 -30.81257 -15.27682 1.000 18.05128 ? 169 TYR A CD2 1 
ATOM   1202 C  CE1 . TYR A 1 169 ? 12.19793 -31.54455 -15.32786 1.000 22.28526 ? 169 TYR A CE1 1 
ATOM   1203 C  CE2 . TYR A 1 169 ? 14.07508 -30.50185 -16.37642 1.000 21.90518 ? 169 TYR A CE2 1 
ATOM   1204 C  CZ  . TYR A 1 169 ? 12.74657 -30.87098 -16.39628 1.000 20.22864 ? 169 TYR A CZ  1 
ATOM   1205 O  OH  . TYR A 1 169 ? 11.96220 -30.56727 -17.48681 1.000 26.27282 ? 169 TYR A OH  1 
ATOM   1206 N  N   . SER A 1 170 ? 18.04732 -33.00779 -12.04698 1.000 16.01591 ? 170 SER A N   1 
ATOM   1207 C  CA  . SER A 1 170 ? 19.04734 -33.22290 -11.01742 1.000 15.15473 ? 170 SER A CA  1 
ATOM   1208 C  C   . SER A 1 170 ? 19.65148 -31.89203 -10.59261 1.000 16.02281 ? 170 SER A C   1 
ATOM   1209 O  O   . SER A 1 170 ? 19.82067 -30.99395 -11.42625 1.000 16.03165 ? 170 SER A O   1 
ATOM   1210 C  CB  . SER A 1 170 ? 20.14952 -34.16197 -11.52372 1.000 11.59772 ? 170 SER A CB  1 
ATOM   1211 O  OG  . SER A 1 170 ? 19.65999 -35.48642 -11.65586 1.000 17.11253 ? 170 SER A OG  1 
ATOM   1212 N  N   . PRO A 1 171 ? 19.98918 -31.73032 -9.30489  1.000 15.38232 ? 171 PRO A N   1 
ATOM   1213 C  CA  . PRO A 1 171 ? 19.88156 -32.70537 -8.20986  1.000 12.07437 ? 171 PRO A CA  1 
ATOM   1214 C  C   . PRO A 1 171 ? 18.51054 -32.74032 -7.53926  1.000 13.79433 ? 171 PRO A C   1 
ATOM   1215 O  O   . PRO A 1 171 ? 18.38445 -33.27832 -6.44310  1.000 13.55662 ? 171 PRO A O   1 
ATOM   1216 C  CB  . PRO A 1 171 ? 20.95811 -32.22201 -7.23294  1.000 12.92585 ? 171 PRO A CB  1 
ATOM   1217 C  CG  . PRO A 1 171 ? 20.91844 -30.72696 -7.38788  1.000 15.06372 ? 171 PRO A CG  1 
ATOM   1218 C  CD  . PRO A 1 171 ? 20.64625 -30.48735 -8.85855  1.000 15.15280 ? 171 PRO A CD  1 
ATOM   1219 N  N   . ALA A 1 172 ? 17.46520 -32.19426 -8.16669  1.000 15.83017 ? 172 ALA A N   1 
ATOM   1220 C  CA  . ALA A 1 172 ? 16.15983 -32.13732 -7.51319  1.000 14.93490 ? 172 ALA A CA  1 
ATOM   1221 C  C   . ALA A 1 172 ? 15.57355 -33.52354 -7.27165  1.000 16.92389 ? 172 ALA A C   1 
ATOM   1222 O  O   . ALA A 1 172 ? 14.78113 -33.70599 -6.33952  1.000 15.04711 ? 172 ALA A O   1 
ATOM   1223 C  CB  . ALA A 1 172 ? 15.18914 -31.29810 -8.34317  1.000 16.08967 ? 172 ALA A CB  1 
ATOM   1224 N  N   . SER A 1 173 ? 15.94179 -34.50624 -8.08960  1.000 10.55721 ? 173 SER A N   1 
ATOM   1225 C  CA  . SER A 1 173 ? 15.37033 -35.84315 -7.99619  1.000 13.31237 ? 173 SER A CA  1 
ATOM   1226 C  C   . SER A 1 173 ? 16.07945 -36.73236 -6.98276  1.000 14.54411 ? 173 SER A C   1 
ATOM   1227 O  O   . SER A 1 173 ? 15.70032 -37.89909 -6.83597  1.000 18.03164 ? 173 SER A O   1 
ATOM   1228 C  CB  . SER A 1 173 ? 15.38436 -36.51889 -9.37173  1.000 16.93651 ? 173 SER A CB  1 
ATOM   1229 O  OG  . SER A 1 173 ? 16.69814 -36.57139 -9.89936  1.000 16.82395 ? 173 SER A OG  1 
ATOM   1230 N  N   . GLU A 1 174 ? 17.09555 -36.22589 -6.29393  1.000 14.23673 ? 174 GLU A N   1 
ATOM   1231 C  CA  . GLU A 1 174 ? 17.74006 -37.00044 -5.24177  1.000 15.01678 ? 174 GLU A CA  1 
ATOM   1232 C  C   . GLU A 1 174 ? 16.87700 -36.96931 -3.98545  1.000 14.66525 ? 174 GLU A C   1 
ATOM   1233 O  O   . GLU A 1 174 ? 16.65856 -35.88990 -3.42089  1.000 13.37588 ? 174 GLU A O   1 
ATOM   1234 C  CB  . GLU A 1 174 ? 19.13553 -36.46418 -4.94863  1.000 13.29752 ? 174 GLU A CB  1 
ATOM   1235 C  CG  . GLU A 1 174 ? 19.75448 -37.01744 -3.66932  1.000 13.73332 ? 174 GLU A CG  1 
ATOM   1236 C  CD  . GLU A 1 174 ? 19.87128 -38.53102 -3.67427  1.000 15.24863 ? 174 GLU A CD  1 
ATOM   1237 O  OE1 . GLU A 1 174 ? 20.11157 -39.11192 -4.75476  1.000 16.63412 ? 174 GLU A OE1 1 
ATOM   1238 O  OE2 . GLU A 1 174 ? 19.71669 -39.14110 -2.59546  1.000 16.86604 ? 174 GLU A OE2 1 
ATOM   1239 N  N   . PRO A 1 175 ? 16.36684 -38.11064 -3.52346  1.000 18.79489 ? 175 PRO A N   1 
ATOM   1240 C  CA  . PRO A 1 175 ? 15.41144 -38.08612 -2.40474  1.000 17.65973 ? 175 PRO A CA  1 
ATOM   1241 C  C   . PRO A 1 175 ? 16.00689 -37.61587 -1.08818  1.000 16.75768 ? 175 PRO A C   1 
ATOM   1242 O  O   . PRO A 1 175 ? 15.28532 -37.02955 -0.27126  1.000 15.85221 ? 175 PRO A O   1 
ATOM   1243 C  CB  . PRO A 1 175 ? 14.94455 -39.54744 -2.31496  1.000 17.53512 ? 175 PRO A CB  1 
ATOM   1244 C  CG  . PRO A 1 175 ? 15.28521 -40.15376 -3.63229  1.000 24.26271 ? 175 PRO A CG  1 
ATOM   1245 C  CD  . PRO A 1 175 ? 16.52354 -39.45883 -4.09189  1.000 21.17186 ? 175 PRO A CD  1 
ATOM   1246 N  N   . SER A 1 176 ? 17.29783 -37.85263 -0.85274  1.000 14.45332 ? 176 SER A N   1 
ATOM   1247 C  CA  . SER A 1 176 ? 17.88629 -37.61172 0.45966   1.000 16.88792 ? 176 SER A CA  1 
ATOM   1248 C  C   . SER A 1 176 ? 18.10591 -36.13510 0.76870   1.000 18.75120 ? 176 SER A C   1 
ATOM   1249 O  O   . SER A 1 176 ? 18.37957 -35.80031 1.92687   1.000 17.65621 ? 176 SER A O   1 
ATOM   1250 C  CB  . SER A 1 176 ? 19.21594 -38.36120 0.58666   1.000 17.58014 ? 176 SER A CB  1 
ATOM   1251 O  OG  . SER A 1 176 ? 20.19095 -37.82783 -0.29075  1.000 18.30608 ? 176 SER A OG  1 
ATOM   1252 N  N   . VAL A 1 177 ? 17.99919 -35.24846 -0.21998  1.000 15.91123 ? 177 VAL A N   1 
ATOM   1253 C  CA  . VAL A 1 177 ? 18.14724 -33.81744 0.02601   1.000 18.22779 ? 177 VAL A CA  1 
ATOM   1254 C  C   . VAL A 1 177 ? 16.76697 -33.19427 0.18651   1.000 15.04337 ? 177 VAL A C   1 
ATOM   1255 O  O   . VAL A 1 177 ? 15.76015 -33.90606 0.27107   1.000 15.74343 ? 177 VAL A O   1 
ATOM   1256 C  CB  . VAL A 1 177 ? 18.94219 -33.12891 -1.09781  1.000 14.21266 ? 177 VAL A CB  1 
ATOM   1257 C  CG1 . VAL A 1 177 ? 20.34549 -33.70986 -1.18212  1.000 13.04603 ? 177 VAL A CG1 1 
ATOM   1258 C  CG2 . VAL A 1 177 ? 18.21495 -33.26499 -2.42699  1.000 13.98998 ? 177 VAL A CG2 1 
ATOM   1259 N  N   . CYS A 1 178 ? 16.70970 -31.86420 0.23259   1.000 15.27834 ? 178 CYS A N   1 
ATOM   1260 C  CA  . CYS A 1 178 ? 15.46897 -31.12736 0.45408   1.000 15.13003 ? 178 CYS A CA  1 
ATOM   1261 C  C   . CYS A 1 178 ? 15.14477 -30.35782 -0.82015  1.000 14.90737 ? 178 CYS A C   1 
ATOM   1262 O  O   . CYS A 1 178 ? 15.80014 -29.35713 -1.13105  1.000 15.86328 ? 178 CYS A O   1 
ATOM   1263 C  CB  . CYS A 1 178 ? 15.60184 -30.18995 1.65315   1.000 14.88630 ? 178 CYS A CB  1 
ATOM   1264 S  SG  . CYS A 1 178 ? 14.07113 -29.87876 2.57421   1.000 12.68468 ? 178 CYS A SG  1 
ATOM   1265 N  N   . THR A 1 179 ? 14.14059 -30.82861 -1.55481  1.000 11.26689 ? 179 THR A N   1 
ATOM   1266 C  CA  . THR A 1 179 ? 13.75529 -30.24934 -2.83543  1.000 11.44939 ? 179 THR A CA  1 
ATOM   1267 C  C   . THR A 1 179 ? 12.63011 -29.24396 -2.62153  1.000 14.33951 ? 179 THR A C   1 
ATOM   1268 O  O   . THR A 1 179 ? 11.61901 -29.56223 -1.98635  1.000 11.27296 ? 179 THR A O   1 
ATOM   1269 C  CB  . THR A 1 179 ? 13.32377 -31.34431 -3.81263  1.000 15.18868 ? 179 THR A CB  1 
ATOM   1270 O  OG1 . THR A 1 179 ? 14.38259 -32.30101 -3.95103  1.000 13.07418 ? 179 THR A OG1 1 
ATOM   1271 C  CG2 . THR A 1 179 ? 13.00399 -30.75354 -5.17786  1.000 14.88609 ? 179 THR A CG2 1 
ATOM   1272 N  N   . VAL A 1 180 ? 12.80056 -28.04095 -3.16608  1.000 13.83678 ? 180 VAL A N   1 
ATOM   1273 C  CA  . VAL A 1 180 ? 11.97855 -26.88902 -2.81002  1.000 13.85130 ? 180 VAL A CA  1 
ATOM   1274 C  C   . VAL A 1 180 ? 11.22255 -26.40352 -4.03955  1.000 12.82049 ? 180 VAL A C   1 
ATOM   1275 O  O   . VAL A 1 180 ? 11.83419 -26.07269 -5.06358  1.000 15.22632 ? 180 VAL A O   1 
ATOM   1276 C  CB  . VAL A 1 180 ? 12.82716 -25.75399 -2.21726  1.000 12.20316 ? 180 VAL A CB  1 
ATOM   1277 C  CG1 . VAL A 1 180 ? 11.93965 -24.59359 -1.80415  1.000 13.59912 ? 180 VAL A CG1 1 
ATOM   1278 C  CG2 . VAL A 1 180 ? 13.63931 -26.26097 -1.03574  1.000 11.04511 ? 180 VAL A CG2 1 
ATOM   1279 N  N   . GLY A 1 181 ? 9.88762  -26.34563 -3.92762  1.000 15.34621 ? 181 GLY A N   1 
ATOM   1280 C  CA  . GLY A 1 181 ? 9.06518  -25.70018 -4.92840  1.000 11.36945 ? 181 GLY A CA  1 
ATOM   1281 C  C   . GLY A 1 181 ? 8.74844  -24.26045 -4.55191  1.000 15.17900 ? 181 GLY A C   1 
ATOM   1282 O  O   . GLY A 1 181 ? 9.07673  -23.78789 -3.46483  1.000 16.87383 ? 181 GLY A O   1 
ATOM   1283 N  N   . ALA A 1 182 ? 8.08749  -23.56054 -5.46975  1.000 12.50809 ? 182 ALA A N   1 
ATOM   1284 C  CA  . ALA A 1 182 ? 7.84625  -22.13364 -5.32068  1.000 11.00811 ? 182 ALA A CA  1 
ATOM   1285 C  C   . ALA A 1 182 ? 6.35350  -21.83177 -5.29005  1.000 14.35590 ? 182 ALA A C   1 
ATOM   1286 O  O   . ALA A 1 182 ? 5.54748  -22.52749 -5.91408  1.000 12.14151 ? 182 ALA A O   1 
ATOM   1287 C  CB  . ALA A 1 182 ? 8.51075  -21.34390 -6.45267  1.000 8.88742  ? 182 ALA A CB  1 
ATOM   1288 N  N   . SER A 1 183 ? 5.99908  -20.77755 -4.55638  1.000 10.93913 ? 183 SER A N   1 
ATOM   1289 C  CA  . SER A 1 183 ? 4.63545  -20.27848 -4.45540  1.000 11.36711 ? 183 SER A CA  1 
ATOM   1290 C  C   . SER A 1 183 ? 4.64342  -18.76138 -4.61718  1.000 11.67245 ? 183 SER A C   1 
ATOM   1291 O  O   . SER A 1 183 ? 5.69057  -18.11296 -4.53790  1.000 8.35177  ? 183 SER A O   1 
ATOM   1292 C  CB  . SER A 1 183 ? 3.99681  -20.67696 -3.11631  1.000 12.11728 ? 183 SER A CB  1 
ATOM   1293 O  OG  . SER A 1 183 ? 4.64337  -20.04408 -2.02529  1.000 17.08873 ? 183 SER A OG  1 
ATOM   1294 N  N   . ASP A 1 184 ? 3.46240  -18.18985 -4.85592  1.000 13.70217 ? 184 ASP A N   1 
ATOM   1295 C  CA  . ASP A 1 184 ? 3.30730  -16.74625 -4.99057  1.000 12.95361 ? 184 ASP A CA  1 
ATOM   1296 C  C   . ASP A 1 184 ? 2.62519  -16.18082 -3.74504  1.000 11.42265 ? 184 ASP A C   1 
ATOM   1297 O  O   . ASP A 1 184 ? 2.24907  -16.91494 -2.82749  1.000 14.00997 ? 184 ASP A O   1 
ATOM   1298 C  CB  . ASP A 1 184 ? 2.54810  -16.39212 -6.27807  1.000 11.83943 ? 184 ASP A CB  1 
ATOM   1299 C  CG  . ASP A 1 184 ? 1.12016  -16.93212 -6.31238  1.000 16.21063 ? 184 ASP A CG  1 
ATOM   1300 O  OD1 . ASP A 1 184 ? 0.59011  -17.38265 -5.27378  1.000 15.98080 ? 184 ASP A OD1 1 
ATOM   1301 O  OD2 . ASP A 1 184 ? 0.51299  -16.90028 -7.40548  1.000 15.47843 ? 184 ASP A OD2 1 
ATOM   1302 N  N   . ARG A 1 185 ? 2.46438  -14.85401 -3.71933  1.000 13.84403 ? 185 ARG A N   1 
ATOM   1303 C  CA  . ARG A 1 185 ? 1.91914  -14.18187 -2.54286  1.000 20.58289 ? 185 ARG A CA  1 
ATOM   1304 C  C   . ARG A 1 185 ? 0.44725  -14.49476 -2.29934  1.000 19.09564 ? 185 ARG A C   1 
ATOM   1305 O  O   . ARG A 1 185 ? -0.06983 -14.15192 -1.23080  1.000 18.59184 ? 185 ARG A O   1 
ATOM   1306 C  CB  . ARG A 1 185 ? 2.10715  -12.66494 -2.65722  1.000 21.80993 ? 185 ARG A CB  1 
ATOM   1307 C  CG  . ARG A 1 185 ? 1.37225  -12.03523 -3.82786  1.000 24.76963 ? 185 ARG A CG  1 
ATOM   1308 C  CD  . ARG A 1 185 ? 1.11439  -10.53752 -3.63923  1.000 28.81964 ? 185 ARG A CD  1 
ATOM   1309 N  NE  . ARG A 1 185 ? 2.29694  -9.71449  -3.86885  1.000 29.73307 ? 185 ARG A NE  1 
ATOM   1310 C  CZ  . ARG A 1 185 ? 2.89729  -8.98083  -2.94097  1.000 35.28181 ? 185 ARG A CZ  1 
ATOM   1311 N  NH1 . ARG A 1 185 ? 2.44536  -8.93089  -1.69840  1.000 35.45870 ? 185 ARG A NH1 1 
ATOM   1312 N  NH2 . ARG A 1 185 ? 3.97458  -8.27348  -3.27032  1.000 28.41463 ? 185 ARG A NH2 1 
ATOM   1313 N  N   . TYR A 1 186 ? -0.23931 -15.12925 -3.24852  1.000 21.29553 ? 186 TYR A N   1 
ATOM   1314 C  CA  . TYR A 1 186 ? -1.62559 -15.53490 -3.06465  1.000 18.57204 ? 186 TYR A CA  1 
ATOM   1315 C  C   . TYR A 1 186 ? -1.75207 -17.01336 -2.71070  1.000 17.41257 ? 186 TYR A C   1 
ATOM   1316 O  O   . TYR A 1 186 ? -2.82544 -17.59868 -2.89179  1.000 18.32460 ? 186 TYR A O   1 
ATOM   1317 C  CB  . TYR A 1 186 ? -2.44080 -15.21256 -4.31757  1.000 15.95083 ? 186 TYR A CB  1 
ATOM   1318 C  CG  . TYR A 1 186 ? -2.44142 -13.74497 -4.68137  1.000 26.37938 ? 186 TYR A CG  1 
ATOM   1319 C  CD1 . TYR A 1 186 ? -3.40763 -12.88422 -4.17771  1.000 25.75567 ? 186 TYR A CD1 1 
ATOM   1320 C  CD2 . TYR A 1 186 ? -1.47538 -13.21977 -5.52867  1.000 22.68989 ? 186 TYR A CD2 1 
ATOM   1321 C  CE1 . TYR A 1 186 ? -3.41137 -11.53880 -4.50890  1.000 37.84700 ? 186 TYR A CE1 1 
ATOM   1322 C  CE2 . TYR A 1 186 ? -1.47101 -11.87706 -5.86537  1.000 28.49939 ? 186 TYR A CE2 1 
ATOM   1323 C  CZ  . TYR A 1 186 ? -2.43948 -11.04156 -5.35304  1.000 35.06178 ? 186 TYR A CZ  1 
ATOM   1324 O  OH  . TYR A 1 186 ? -2.43000 -9.70693  -5.69121  1.000 46.26286 ? 186 TYR A OH  1 
ATOM   1325 N  N   . ASP A 1 187 ? -0.67230 -17.62369 -2.21552  1.000 14.58159 ? 187 ASP A N   1 
ATOM   1326 C  CA  . ASP A 1 187 ? -0.64959 -19.03196 -1.81438  1.000 13.84611 ? 187 ASP A CA  1 
ATOM   1327 C  C   . ASP A 1 187 ? -1.03422 -19.96443 -2.96025  1.000 17.49579 ? 187 ASP A C   1 
ATOM   1328 O  O   . ASP A 1 187 ? -1.62348 -21.02567 -2.74240  1.000 19.59199 ? 187 ASP A O   1 
ATOM   1329 C  CB  . ASP A 1 187 ? -1.54181 -19.27936 -0.59491  1.000 15.37636 ? 187 ASP A CB  1 
ATOM   1330 C  CG  . ASP A 1 187 ? -0.87289 -18.87833 0.70572   1.000 19.03433 ? 187 ASP A CG  1 
ATOM   1331 O  OD1 . ASP A 1 187 ? 0.30395  -18.46066 0.66616   1.000 15.72336 ? 187 ASP A OD1 1 
ATOM   1332 O  OD2 . ASP A 1 187 ? -1.52264 -18.98195 1.76765   1.000 20.09633 ? 187 ASP A OD2 1 
ATOM   1333 N  N   . ARG A 1 188 ? -0.70340 -19.57686 -4.18597  1.000 14.64148 ? 188 ARG A N   1 
ATOM   1334 C  CA  . ARG A 1 188 ? -0.81804 -20.45095 -5.34156  1.000 18.90223 ? 188 ARG A CA  1 
ATOM   1335 C  C   . ARG A 1 188 ? 0.55830  -20.99363 -5.69586  1.000 19.89561 ? 188 ARG A C   1 
ATOM   1336 O  O   . ARG A 1 188 ? 1.57962  -20.35065 -5.44139  1.000 18.22341 ? 188 ARG A O   1 
ATOM   1337 C  CB  . ARG A 1 188 ? -1.40281 -19.70886 -6.54627  1.000 17.84923 ? 188 ARG A CB  1 
ATOM   1338 C  CG  . ARG A 1 188 ? -2.76397 -19.08193 -6.30395  1.000 16.99763 ? 188 ARG A CG  1 
ATOM   1339 C  CD  . ARG A 1 188 ? -3.20527 -18.22221 -7.48322  1.000 18.66076 ? 188 ARG A CD  1 
ATOM   1340 N  NE  . ARG A 1 188 ? -2.30016 -17.10363 -7.72390  1.000 17.17194 ? 188 ARG A NE  1 
ATOM   1341 C  CZ  . ARG A 1 188 ? -2.60057 -16.03966 -8.45718  1.000 22.02235 ? 188 ARG A CZ  1 
ATOM   1342 N  NH1 . ARG A 1 188 ? -3.78836 -15.90279 -9.02323  1.000 19.50246 ? 188 ARG A NH1 1 
ATOM   1343 N  NH2 . ARG A 1 188 ? -1.68823 -15.08580 -8.62167  1.000 20.06950 ? 188 ARG A NH2 1 
ATOM   1344 N  N   . ARG A 1 189 ? 0.58263  -22.19064 -6.27363  1.000 18.19570 ? 189 ARG A N   1 
ATOM   1345 C  CA  . ARG A 1 189 ? 1.82888  -22.69739 -6.82532  1.000 16.87661 ? 189 ARG A CA  1 
ATOM   1346 C  C   . ARG A 1 189 ? 2.28729  -21.78077 -7.94807  1.000 14.99346 ? 189 ARG A C   1 
ATOM   1347 O  O   . ARG A 1 189 ? 1.48981  -21.38584 -8.80383  1.000 12.18360 ? 189 ARG A O   1 
ATOM   1348 C  CB  . ARG A 1 189 ? 1.65398  -24.12363 -7.34489  1.000 20.68136 ? 189 ARG A CB  1 
ATOM   1349 C  CG  . ARG A 1 189 ? 2.90031  -24.67917 -8.01842  1.000 16.85180 ? 189 ARG A CG  1 
ATOM   1350 C  CD  . ARG A 1 189 ? 2.72650  -26.13803 -8.40660  1.000 16.83507 ? 189 ARG A CD  1 
ATOM   1351 N  NE  . ARG A 1 189 ? 1.71831  -26.32246 -9.44389  1.000 25.94728 ? 189 ARG A NE  1 
ATOM   1352 C  CZ  . ARG A 1 189 ? 1.97642  -26.33939 -10.74455 1.000 24.34661 ? 189 ARG A CZ  1 
ATOM   1353 N  NH1 . ARG A 1 189 ? 3.20448  -26.17321 -11.20757 1.000 23.36809 ? 189 ARG A NH1 1 
ATOM   1354 N  NH2 . ARG A 1 189 ? 0.97724  -26.52743 -11.60234 1.000 28.31564 ? 189 ARG A NH2 1 
ATOM   1355 N  N   . SER A 1 190 ? 3.56703  -21.41837 -7.92608  1.000 11.68319 ? 190 SER A N   1 
ATOM   1356 C  CA  . SER A 1 190 ? 4.12062  -20.62018 -9.00830  1.000 16.33400 ? 190 SER A CA  1 
ATOM   1357 C  C   . SER A 1 190 ? 3.91291  -21.34200 -10.33374 1.000 14.57272 ? 190 SER A C   1 
ATOM   1358 O  O   . SER A 1 190 ? 4.13209  -22.55225 -10.44071 1.000 18.02227 ? 190 SER A O   1 
ATOM   1359 C  CB  . SER A 1 190 ? 5.60489  -20.35022 -8.76154  1.000 13.14552 ? 190 SER A CB  1 
ATOM   1360 O  OG  . SER A 1 190 ? 5.79191  -19.60397 -7.57034  1.000 15.96543 ? 190 SER A OG  1 
ATOM   1361 N  N   . SER A 1 191 ? 3.45985  -20.59124 -11.34234 1.000 17.90193 ? 191 SER A N   1 
ATOM   1362 C  CA  . SER A 1 191 ? 3.08933  -21.19152 -12.61991 1.000 21.63715 ? 191 SER A CA  1 
ATOM   1363 C  C   . SER A 1 191 ? 4.24127  -21.95163 -13.26243 1.000 16.13778 ? 191 SER A C   1 
ATOM   1364 O  O   . SER A 1 191 ? 4.00083  -22.85926 -14.06570 1.000 16.59379 ? 191 SER A O   1 
ATOM   1365 C  CB  . SER A 1 191 ? 2.58251  -20.11264 -13.57678 1.000 21.58648 ? 191 SER A CB  1 
ATOM   1366 O  OG  . SER A 1 191 ? 3.57198  -19.12504 -13.80494 1.000 22.79691 ? 191 SER A OG  1 
ATOM   1367 N  N   . PHE A 1 192 ? 5.48156  -21.60872 -12.92166 1.000 13.90467 ? 192 PHE A N   1 
ATOM   1368 C  CA  . PHE A 1 192 ? 6.65392  -22.26251 -13.48494 1.000 14.76644 ? 192 PHE A CA  1 
ATOM   1369 C  C   . PHE A 1 192 ? 7.17228  -23.40985 -12.62939 1.000 15.61329 ? 192 PHE A C   1 
ATOM   1370 O  O   . PHE A 1 192 ? 7.96032  -24.22357 -13.12416 1.000 18.89140 ? 192 PHE A O   1 
ATOM   1371 C  CB  . PHE A 1 192 ? 7.77534  -21.23637 -13.67065 1.000 15.72913 ? 192 PHE A CB  1 
ATOM   1372 C  CG  . PHE A 1 192 ? 8.03482  -20.40434 -12.44420 1.000 17.49482 ? 192 PHE A CG  1 
ATOM   1373 C  CD1 . PHE A 1 192 ? 8.74173  -20.92703 -11.37285 1.000 14.06702 ? 192 PHE A CD1 1 
ATOM   1374 C  CD2 . PHE A 1 192 ? 7.56546  -19.10334 -12.35924 1.000 16.29095 ? 192 PHE A CD2 1 
ATOM   1375 C  CE1 . PHE A 1 192 ? 8.97047  -20.17447 -10.24376 1.000 14.35653 ? 192 PHE A CE1 1 
ATOM   1376 C  CE2 . PHE A 1 192 ? 7.79883  -18.34194 -11.23035 1.000 15.08568 ? 192 PHE A CE2 1 
ATOM   1377 C  CZ  . PHE A 1 192 ? 8.50421  -18.87775 -10.17307 1.000 12.56795 ? 192 PHE A CZ  1 
ATOM   1378 N  N   . SER A 1 193 ? 6.75500  -23.48855 -11.36723 1.000 15.89596 ? 193 SER A N   1 
ATOM   1379 C  CA  . SER A 1 193 ? 7.38427  -24.39287 -10.41373 1.000 21.29066 ? 193 SER A CA  1 
ATOM   1380 C  C   . SER A 1 193 ? 7.14426  -25.84781 -10.79246 1.000 16.65602 ? 193 SER A C   1 
ATOM   1381 O  O   . SER A 1 193 ? 6.02169  -26.24011 -11.12620 1.000 20.07946 ? 193 SER A O   1 
ATOM   1382 C  CB  . SER A 1 193 ? 6.85534  -24.12464 -9.00509  1.000 18.14680 ? 193 SER A CB  1 
ATOM   1383 O  OG  . SER A 1 193 ? 7.42052  -25.02669 -8.06773  1.000 13.17956 ? 193 SER A OG  1 
ATOM   1384 N  N   . ASN A 1 194 ? 8.20839  -26.64567 -10.74227 1.000 16.75832 ? 194 ASN A N   1 
ATOM   1385 C  CA  . ASN A 1 194 ? 8.06869  -28.08234 -10.88672 1.000 13.78898 ? 194 ASN A CA  1 
ATOM   1386 C  C   . ASN A 1 194 ? 7.30457  -28.65427 -9.69462  1.000 14.76536 ? 194 ASN A C   1 
ATOM   1387 O  O   . ASN A 1 194 ? 7.12283  -28.00568 -8.66068  1.000 17.72469 ? 194 ASN A O   1 
ATOM   1388 C  CB  . ASN A 1 194 ? 9.43797  -28.75192 -11.00865 1.000 14.81414 ? 194 ASN A CB  1 
ATOM   1389 C  CG  . ASN A 1 194 ? 10.00654 -28.67025 -12.41243 1.000 19.66193 ? 194 ASN A CG  1 
ATOM   1390 O  OD1 . ASN A 1 194 ? 9.31594  -28.27788 -13.35256 1.000 20.32059 ? 194 ASN A OD1 1 
ATOM   1391 N  ND2 . ASN A 1 194 ? 11.26893 -29.05634 -12.56325 1.000 15.57044 ? 194 ASN A ND2 1 
ATOM   1392 N  N   . TYR A 1 195 ? 6.85664  -29.89515 -9.85091  1.000 18.65656 ? 195 TYR A N   1 
ATOM   1393 C  CA  . TYR A 1 195 ? 6.08831  -30.57421 -8.81918  1.000 14.41801 ? 195 TYR A CA  1 
ATOM   1394 C  C   . TYR A 1 195 ? 6.50000  -32.04137 -8.80886  1.000 16.18678 ? 195 TYR A C   1 
ATOM   1395 O  O   . TYR A 1 195 ? 7.49874  -32.43235 -9.42099  1.000 17.81229 ? 195 TYR A O   1 
ATOM   1396 C  CB  . TYR A 1 195 ? 4.58516  -30.38703 -9.06214  1.000 15.25401 ? 195 TYR A CB  1 
ATOM   1397 C  CG  . TYR A 1 195 ? 4.15182  -30.75546 -10.46295 1.000 19.39766 ? 195 TYR A CG  1 
ATOM   1398 C  CD1 . TYR A 1 195 ? 3.82768  -32.06633 -10.78722 1.000 18.83030 ? 195 TYR A CD1 1 
ATOM   1399 C  CD2 . TYR A 1 195 ? 4.07014  -29.79311 -11.46231 1.000 18.67058 ? 195 TYR A CD2 1 
ATOM   1400 C  CE1 . TYR A 1 195 ? 3.43357  -32.40960 -12.06478 1.000 24.55889 ? 195 TYR A CE1 1 
ATOM   1401 C  CE2 . TYR A 1 195 ? 3.67677  -30.12738 -12.74516 1.000 18.52178 ? 195 TYR A CE2 1 
ATOM   1402 C  CZ  . TYR A 1 195 ? 3.36043  -31.43701 -13.04063 1.000 23.63193 ? 195 TYR A CZ  1 
ATOM   1403 O  OH  . TYR A 1 195 ? 2.96692  -31.77685 -14.31532 1.000 31.85764 ? 195 TYR A OH  1 
ATOM   1404 N  N   . GLY A 1 196 ? 5.72574  -32.85917 -8.11162  1.000 18.38303 ? 196 GLY A N   1 
ATOM   1405 C  CA  . GLY A 1 196 ? 5.95704  -34.28777 -8.06033  1.000 19.28741 ? 196 GLY A CA  1 
ATOM   1406 C  C   . GLY A 1 196 ? 6.15543  -34.78738 -6.64050  1.000 17.02388 ? 196 GLY A C   1 
ATOM   1407 O  O   . GLY A 1 196 ? 6.25328  -34.02462 -5.68089  1.000 17.26931 ? 196 GLY A O   1 
ATOM   1408 N  N   . SER A 1 197 ? 6.22054  -36.11667 -6.53665  1.000 14.59119 ? 197 SER A N   1 
ATOM   1409 C  CA  . SER A 1 197 ? 6.36446  -36.76624 -5.24005  1.000 23.12439 ? 197 SER A CA  1 
ATOM   1410 C  C   . SER A 1 197 ? 7.72107  -36.50608 -4.59988  1.000 20.21536 ? 197 SER A C   1 
ATOM   1411 O  O   . SER A 1 197 ? 7.85649  -36.66545 -3.38348  1.000 18.02177 ? 197 SER A O   1 
ATOM   1412 C  CB  . SER A 1 197 ? 6.14480  -38.27199 -5.38332  1.000 18.86738 ? 197 SER A CB  1 
ATOM   1413 O  OG  . SER A 1 197 ? 7.05745  -38.82654 -6.31494  1.000 24.28991 ? 197 SER A OG  1 
ATOM   1414 N  N   . VAL A 1 198 ? 8.72787  -36.11501 -5.38307  1.000 19.36488 ? 198 VAL A N   1 
ATOM   1415 C  CA  . VAL A 1 198 ? 10.05478 -35.91534 -4.81992  1.000 19.40494 ? 198 VAL A CA  1 
ATOM   1416 C  C   . VAL A 1 198 ? 10.14855 -34.59279 -4.06687  1.000 16.17016 ? 198 VAL A C   1 
ATOM   1417 O  O   . VAL A 1 198 ? 11.08307 -34.39181 -3.28083  1.000 17.25168 ? 198 VAL A O   1 
ATOM   1418 C  CB  . VAL A 1 198 ? 11.11669 -36.00171 -5.93219  1.000 19.49311 ? 198 VAL A CB  1 
ATOM   1419 C  CG1 . VAL A 1 198 ? 11.11396 -34.73748 -6.78748  1.000 19.41588 ? 198 VAL A CG1 1 
ATOM   1420 C  CG2 . VAL A 1 198 ? 12.49849 -36.26817 -5.34558  1.000 18.03093 ? 198 VAL A CG2 1 
ATOM   1421 N  N   . LEU A 1 199 ? 9.18663  -33.69400 -4.26273  1.000 15.33005 ? 199 LEU A N   1 
ATOM   1422 C  CA  . LEU A 1 199 ? 9.21364  -32.40948 -3.57815  1.000 13.87625 ? 199 LEU A CA  1 
ATOM   1423 C  C   . LEU A 1 199 ? 8.96675  -32.59011 -2.08558  1.000 13.70710 ? 199 LEU A C   1 
ATOM   1424 O  O   . LEU A 1 199 ? 8.10928  -33.37335 -1.66757  1.000 15.80590 ? 199 LEU A O   1 
ATOM   1425 C  CB  . LEU A 1 199 ? 8.17424  -31.45664 -4.17328  1.000 13.20483 ? 199 LEU A CB  1 
ATOM   1426 C  CG  . LEU A 1 199 ? 8.70603  -30.43382 -5.18166  1.000 20.67321 ? 199 LEU A CG  1 
ATOM   1427 C  CD1 . LEU A 1 199 ? 9.09452  -31.08404 -6.50715  1.000 18.43561 ? 199 LEU A CD1 1 
ATOM   1428 C  CD2 . LEU A 1 199 ? 7.69799  -29.31600 -5.39832  1.000 15.06140 ? 199 LEU A CD2 1 
ATOM   1429 N  N   . ASP A 1 200 ? 9.73220  -31.85582 -1.28045  1.000 13.70441 ? 200 ASP A N   1 
ATOM   1430 C  CA  . ASP A 1 200 ? 9.62372  -31.91434 0.17083   1.000 13.03667 ? 200 ASP A CA  1 
ATOM   1431 C  C   . ASP A 1 200 ? 8.85812  -30.74211 0.76565   1.000 11.49778 ? 200 ASP A C   1 
ATOM   1432 O  O   . ASP A 1 200 ? 8.15377  -30.91970 1.76534   1.000 12.17011 ? 200 ASP A O   1 
ATOM   1433 C  CB  . ASP A 1 200 ? 11.02074 -31.95944 0.80099   1.000 14.65555 ? 200 ASP A CB  1 
ATOM   1434 C  CG  . ASP A 1 200 ? 11.80626 -33.19019 0.39915   1.000 15.56865 ? 200 ASP A CG  1 
ATOM   1435 O  OD1 . ASP A 1 200 ? 11.45237 -34.29748 0.85062   1.000 17.03522 ? 200 ASP A OD1 1 
ATOM   1436 O  OD2 . ASP A 1 200 ? 12.78208 -33.05405 -0.36753  1.000 10.88511 ? 200 ASP A OD2 1 
ATOM   1437 N  N   . ILE A 1 201 ? 8.96785  -29.55339 0.17331   1.000 13.00120 ? 201 ILE A N   1 
ATOM   1438 C  CA  . ILE A 1 201 ? 8.48396  -28.33165 0.80483   1.000 11.38013 ? 201 ILE A CA  1 
ATOM   1439 C  C   . ILE A 1 201 ? 8.34407  -27.26254 -0.26861  1.000 11.09006 ? 201 ILE A C   1 
ATOM   1440 O  O   . ILE A 1 201 ? 8.97154  -27.33681 -1.32684  1.000 11.29759 ? 201 ILE A O   1 
ATOM   1441 C  CB  . ILE A 1 201 ? 9.44901  -27.88556 1.93480   1.000 13.74271 ? 201 ILE A CB  1 
ATOM   1442 C  CG1 . ILE A 1 201 ? 8.81756  -26.79888 2.80931   1.000 11.61841 ? 201 ILE A CG1 1 
ATOM   1443 C  CG2 . ILE A 1 201 ? 10.78073 -27.42591 1.35032   1.000 14.21757 ? 201 ILE A CG2 1 
ATOM   1444 C  CD1 . ILE A 1 201 ? 7.64519  -27.28687 3.62557   1.000 13.25012 ? 201 ILE A CD1 1 
ATOM   1445 N  N   . PHE A 1 202 ? 7.50119  -26.26798 -0.00022  1.000 13.31717 ? 202 PHE A N   1 
ATOM   1446 C  CA  . PHE A 1 202 ? 7.36346  -25.08682 -0.83786  1.000 12.17206 ? 202 PHE A CA  1 
ATOM   1447 C  C   . PHE A 1 202 ? 7.84222  -23.84939 -0.08805  1.000 15.88614 ? 202 PHE A C   1 
ATOM   1448 O  O   . PHE A 1 202 ? 7.74389  -23.76540 1.13954   1.000 11.49190 ? 202 PHE A O   1 
ATOM   1449 C  CB  . PHE A 1 202 ? 5.91083  -24.88147 -1.28242  1.000 16.13407 ? 202 PHE A CB  1 
ATOM   1450 C  CG  . PHE A 1 202 ? 5.50528  -25.72601 -2.45782  1.000 16.29663 ? 202 PHE A CG  1 
ATOM   1451 C  CD1 . PHE A 1 202 ? 5.03303  -27.01646 -2.27587  1.000 15.57363 ? 202 PHE A CD1 1 
ATOM   1452 C  CD2 . PHE A 1 202 ? 5.58409  -25.22276 -3.74623  1.000 14.95652 ? 202 PHE A CD2 1 
ATOM   1453 C  CE1 . PHE A 1 202 ? 4.65493  -27.79341 -3.36164  1.000 13.94472 ? 202 PHE A CE1 1 
ATOM   1454 C  CE2 . PHE A 1 202 ? 5.20855  -25.99316 -4.83472  1.000 15.90985 ? 202 PHE A CE2 1 
ATOM   1455 C  CZ  . PHE A 1 202 ? 4.74320  -27.27922 -4.64170  1.000 17.31946 ? 202 PHE A CZ  1 
ATOM   1456 N  N   . GLY A 1 203 ? 8.35785  -22.88574 -0.84409  1.000 16.66880 ? 203 GLY A N   1 
ATOM   1457 C  CA  . GLY A 1 203 ? 8.76678  -21.61669 -0.29476  1.000 11.61092 ? 203 GLY A CA  1 
ATOM   1458 C  C   . GLY A 1 203 ? 8.36661  -20.47782 -1.20768  1.000 12.56635 ? 203 GLY A C   1 
ATOM   1459 O  O   . GLY A 1 203 ? 8.01175  -20.68608 -2.37164  1.000 10.52830 ? 203 GLY A O   1 
ATOM   1460 N  N   . PRO A 1 204 ? 8.40156  -19.25027 -0.69266  1.000 14.12334 ? 204 PRO A N   1 
ATOM   1461 C  CA  . PRO A 1 204 ? 8.06174  -18.08908 -1.52701  1.000 12.15012 ? 204 PRO A CA  1 
ATOM   1462 C  C   . PRO A 1 204 ? 9.04060  -17.94799 -2.68381  1.000 13.14858 ? 204 PRO A C   1 
ATOM   1463 O  O   . PRO A 1 204 ? 10.25690 -17.92229 -2.48888  1.000 10.83300 ? 204 PRO A O   1 
ATOM   1464 C  CB  . PRO A 1 204 ? 8.16120  -16.91151 -0.55024  1.000 12.27525 ? 204 PRO A CB  1 
ATOM   1465 C  CG  . PRO A 1 204 ? 8.02336  -17.52938 0.81064   1.000 16.88192 ? 204 PRO A CG  1 
ATOM   1466 C  CD  . PRO A 1 204 ? 8.67745  -18.86943 0.70200   1.000 17.40816 ? 204 PRO A CD  1 
ATOM   1467 N  N   . GLY A 1 205 ? 8.50176  -17.85427 -3.89745  1.000 10.23633 ? 205 GLY A N   1 
ATOM   1468 C  CA  . GLY A 1 205 ? 9.34659  -17.91395 -5.07484  1.000 10.19187 ? 205 GLY A CA  1 
ATOM   1469 C  C   . GLY A 1 205 ? 9.05242  -16.92189 -6.18198  1.000 13.74150 ? 205 GLY A C   1 
ATOM   1470 O  O   . GLY A 1 205 ? 9.87040  -16.75778 -7.09158  1.000 16.78037 ? 205 GLY A O   1 
ATOM   1471 N  N   . THR A 1 206 ? 7.90280  -16.25589 -6.13079  1.000 10.20098 ? 206 THR A N   1 
ATOM   1472 C  CA  . THR A 1 206 ? 7.48727  -15.33184 -7.17891  1.000 11.99777 ? 206 THR A CA  1 
ATOM   1473 C  C   . THR A 1 206 ? 7.61473  -13.89626 -6.68641  1.000 13.50561 ? 206 THR A C   1 
ATOM   1474 O  O   . THR A 1 206 ? 7.09858  -13.55512 -5.61614  1.000 13.55424 ? 206 THR A O   1 
ATOM   1475 C  CB  . THR A 1 206 ? 6.04824  -15.60816 -7.62507  1.000 13.57109 ? 206 THR A CB  1 
ATOM   1476 O  OG1 . THR A 1 206 ? 5.95051  -16.94280 -8.13845  1.000 13.89134 ? 206 THR A OG1 1 
ATOM   1477 C  CG2 . THR A 1 206 ? 5.63286  -14.62594 -8.70980  1.000 17.22910 ? 206 THR A CG2 1 
ATOM   1478 N  N   . ASP A 1 207 ? 8.29658  -13.06208 -7.47666  1.000 14.16545 ? 207 ASP A N   1 
ATOM   1479 C  CA  . ASP A 1 207 ? 8.50310  -11.64321 -7.18105  1.000 17.43578 ? 207 ASP A CA  1 
ATOM   1480 C  C   . ASP A 1 207 ? 9.16892  -11.46725 -5.81186  1.000 12.64999 ? 207 ASP A C   1 
ATOM   1481 O  O   . ASP A 1 207 ? 8.57399  -10.98623 -4.84616  1.000 17.48907 ? 207 ASP A O   1 
ATOM   1482 C  CB  . ASP A 1 207 ? 7.17968  -10.87049 -7.26069  1.000 16.25938 ? 207 ASP A CB  1 
ATOM   1483 C  CG  . ASP A 1 207 ? 6.55782  -10.91597 -8.64542  1.000 26.49390 ? 207 ASP A CG  1 
ATOM   1484 O  OD1 . ASP A 1 207 ? 7.31302  -10.95122 -9.64052  1.000 21.80450 ? 207 ASP A OD1 1 
ATOM   1485 O  OD2 . ASP A 1 207 ? 5.31221  -10.91371 -8.74085  1.000 28.21004 ? 207 ASP A OD2 1 
ATOM   1486 N  N   . ILE A 1 208 ? 10.43442 -11.87405 -5.76056  1.000 13.29227 ? 208 ILE A N   1 
ATOM   1487 C  CA  . ILE A 1 208 ? 11.21599 -11.88468 -4.52847  1.000 11.70168 ? 208 ILE A CA  1 
ATOM   1488 C  C   . ILE A 1 208 ? 12.26539 -10.78589 -4.61534  1.000 12.67622 ? 208 ILE A C   1 
ATOM   1489 O  O   . ILE A 1 208 ? 13.14133 -10.82174 -5.48871  1.000 12.43059 ? 208 ILE A O   1 
ATOM   1490 C  CB  . ILE A 1 208 ? 11.86794 -13.25426 -4.28715  1.000 13.44383 ? 208 ILE A CB  1 
ATOM   1491 C  CG1 . ILE A 1 208 ? 10.80125 -14.35350 -4.26525  1.000 10.14823 ? 208 ILE A CG1 1 
ATOM   1492 C  CG2 . ILE A 1 208 ? 12.65229 -13.25122 -2.98503  1.000 15.15245 ? 208 ILE A CG2 1 
ATOM   1493 C  CD1 . ILE A 1 208 ? 9.73943  -14.14207 -3.21034  1.000 16.15014 ? 208 ILE A CD1 1 
ATOM   1494 N  N   . LEU A 1 209 ? 12.17492 -9.81160  -3.71183  1.000 14.07436 ? 209 LEU A N   1 
ATOM   1495 C  CA  . LEU A 1 209 ? 13.11869 -8.70315  -3.66120  1.000 15.07065 ? 209 LEU A CA  1 
ATOM   1496 C  C   . LEU A 1 209 ? 14.32101 -9.09041  -2.81055  1.000 14.12992 ? 209 LEU A C   1 
ATOM   1497 O  O   . LEU A 1 209 ? 14.16145 -9.56637  -1.68131  1.000 10.38857 ? 209 LEU A O   1 
ATOM   1498 C  CB  . LEU A 1 209 ? 12.45058 -7.45003  -3.09357  1.000 12.48786 ? 209 LEU A CB  1 
ATOM   1499 C  CG  . LEU A 1 209 ? 13.32517 -6.20545  -2.91836  1.000 14.70973 ? 209 LEU A CG  1 
ATOM   1500 C  CD1 . LEU A 1 209 ? 13.79488 -5.67197  -4.26473  1.000 16.23971 ? 209 LEU A CD1 1 
ATOM   1501 C  CD2 . LEU A 1 209 ? 12.59108 -5.12491  -2.13439  1.000 16.07695 ? 209 LEU A CD2 1 
ATOM   1502 N  N   . SER A 1 210 ? 15.51861 -8.88566  -3.35377  1.000 12.17964 ? 210 SER A N   1 
ATOM   1503 C  CA  . SER A 1 210 ? 16.74825 -9.21682  -2.64563  1.000 16.02601 ? 210 SER A CA  1 
ATOM   1504 C  C   . SER A 1 210 ? 17.89090 -8.40203  -3.23954  1.000 12.98917 ? 210 SER A C   1 
ATOM   1505 O  O   . SER A 1 210 ? 17.68804 -7.53581  -4.09406  1.000 16.34568 ? 210 SER A O   1 
ATOM   1506 C  CB  . SER A 1 210 ? 17.04067 -10.71846 -2.71089  1.000 11.50470 ? 210 SER A CB  1 
ATOM   1507 O  OG  . SER A 1 210 ? 18.19602 -11.03676 -1.95806  1.000 9.32423  ? 210 SER A OG  1 
ATOM   1508 N  N   . THR A 1 211 ? 19.10378 -8.69819  -2.78311  1.000 15.19540 ? 211 THR A N   1 
ATOM   1509 C  CA  . THR A 1 211 ? 20.26914 -7.93605  -3.20269  1.000 13.11969 ? 211 THR A CA  1 
ATOM   1510 C  C   . THR A 1 211 ? 20.65843 -8.27137  -4.64156  1.000 15.17113 ? 211 THR A C   1 
ATOM   1511 O  O   . THR A 1 211 ? 20.26429 -9.29624  -5.20624  1.000 11.98770 ? 211 THR A O   1 
ATOM   1512 C  CB  . THR A 1 211 ? 21.44674 -8.19985  -2.26464  1.000 15.32640 ? 211 THR A CB  1 
ATOM   1513 O  OG1 . THR A 1 211 ? 21.56875 -9.60964  -2.03019  1.000 13.93855 ? 211 THR A OG1 1 
ATOM   1514 C  CG2 . THR A 1 211 ? 21.24084 -7.47654  -0.94042  1.000 14.06232 ? 211 THR A CG2 1 
ATOM   1515 N  N   . TRP A 1 212 ? 21.43986 -7.37327  -5.23523  1.000 15.62209 ? 212 TRP A N   1 
ATOM   1516 C  CA  . TRP A 1 212 ? 21.92584 -7.53535  -6.59599  1.000 13.56724 ? 212 TRP A CA  1 
ATOM   1517 C  C   . TRP A 1 212 ? 23.30685 -6.90032  -6.67567  1.000 15.21833 ? 212 TRP A C   1 
ATOM   1518 O  O   . TRP A 1 212 ? 23.71507 -6.14438  -5.79033  1.000 15.24607 ? 212 TRP A O   1 
ATOM   1519 C  CB  . TRP A 1 212 ? 20.95150 -6.91886  -7.60877  1.000 12.67570 ? 212 TRP A CB  1 
ATOM   1520 C  CG  . TRP A 1 212 ? 21.12597 -7.40491  -9.01585  1.000 13.77282 ? 212 TRP A CG  1 
ATOM   1521 C  CD1 . TRP A 1 212 ? 21.72334 -6.73700  -10.04278 1.000 16.50374 ? 212 TRP A CD1 1 
ATOM   1522 C  CD2 . TRP A 1 212 ? 20.68701 -8.66047  -9.55507  1.000 11.67372 ? 212 TRP A CD2 1 
ATOM   1523 N  NE1 . TRP A 1 212 ? 21.68776 -7.49666  -11.18608 1.000 13.99597 ? 212 TRP A NE1 1 
ATOM   1524 C  CE2 . TRP A 1 212 ? 21.05695 -8.68189  -10.91386 1.000 14.80402 ? 212 TRP A CE2 1 
ATOM   1525 C  CE3 . TRP A 1 212 ? 20.02121 -9.76891  -9.01996  1.000 17.70675 ? 212 TRP A CE3 1 
ATOM   1526 C  CZ2 . TRP A 1 212 ? 20.78390 -9.76655  -11.74610 1.000 15.05566 ? 212 TRP A CZ2 1 
ATOM   1527 C  CZ3 . TRP A 1 212 ? 19.74918 -10.84570 -9.85001  1.000 18.01109 ? 212 TRP A CZ3 1 
ATOM   1528 C  CH2 . TRP A 1 212 ? 20.13090 -10.83550 -11.19716 1.000 15.19942 ? 212 TRP A CH2 1 
ATOM   1529 N  N   . ILE A 1 213 ? 24.03397 -7.22372  -7.74456  1.000 13.88182 ? 213 ILE A N   1 
ATOM   1530 C  CA  . ILE A 1 213 ? 25.40204 -6.74079  -7.90207  1.000 13.86929 ? 213 ILE A CA  1 
ATOM   1531 C  C   . ILE A 1 213 ? 25.38896 -5.24208  -8.16794  1.000 20.41945 ? 213 ILE A C   1 
ATOM   1532 O  O   . ILE A 1 213 ? 24.35154 -4.66703  -8.51669  1.000 18.33941 ? 213 ILE A O   1 
ATOM   1533 C  CB  . ILE A 1 213 ? 26.15140 -7.49358  -9.01730  1.000 17.37075 ? 213 ILE A CB  1 
ATOM   1534 C  CG1 . ILE A 1 213 ? 25.43944 -7.33674  -10.36302 1.000 22.26214 ? 213 ILE A CG1 1 
ATOM   1535 C  CG2 . ILE A 1 213 ? 26.31567 -8.96299  -8.64908  1.000 18.26969 ? 213 ILE A CG2 1 
ATOM   1536 C  CD1 . ILE A 1 213 ? 26.17748 -7.99841  -11.50721 1.000 22.35062 ? 213 ILE A CD1 1 
ATOM   1537 N  N   . GLY A 1 214 ? 26.54389 -4.60156  -8.00646  1.000 15.40316 ? 214 GLY A N   1 
ATOM   1538 C  CA  . GLY A 1 214 ? 26.59751 -3.15715  -8.07462  1.000 18.36792 ? 214 GLY A CA  1 
ATOM   1539 C  C   . GLY A 1 214 ? 26.01483 -2.46640  -6.86546  1.000 15.17922 ? 214 GLY A C   1 
ATOM   1540 O  O   . GLY A 1 214 ? 25.74889 -1.26266  -6.91804  1.000 16.09095 ? 214 GLY A O   1 
ATOM   1541 N  N   . GLY A 1 215 ? 25.80725 -3.19810  -5.77243  1.000 14.11004 ? 215 GLY A N   1 
ATOM   1542 C  CA  . GLY A 1 215 ? 25.23754 -2.61589  -4.57272  1.000 19.03446 ? 215 GLY A CA  1 
ATOM   1543 C  C   . GLY A 1 215 ? 23.78434 -2.21870  -4.70085  1.000 19.76767 ? 215 GLY A C   1 
ATOM   1544 O  O   . GLY A 1 215 ? 23.33984 -1.29395  -4.01003  1.000 17.26960 ? 215 GLY A O   1 
ATOM   1545 N  N   . SER A 1 216 ? 23.02499 -2.89947  -5.56112  1.000 17.17804 ? 216 SER A N   1 
ATOM   1546 C  CA  . SER A 1 216 ? 21.63616 -2.56349  -5.82926  1.000 14.42152 ? 216 SER A CA  1 
ATOM   1547 C  C   . SER A 1 216 ? 20.70938 -3.68376  -5.35315  1.000 16.71827 ? 216 SER A C   1 
ATOM   1548 O  O   . SER A 1 216 ? 21.12908 -4.61623  -4.65785  1.000 13.27148 ? 216 SER A O   1 
ATOM   1549 C  CB  . SER A 1 216 ? 21.46055 -2.27114  -7.32023  1.000 13.29438 ? 216 SER A CB  1 
ATOM   1550 O  OG  . SER A 1 216 ? 21.82888 -3.39009  -8.10640  1.000 21.02206 ? 216 SER A OG  1 
ATOM   1551 N  N   . THR A 1 217 ? 19.43274 -3.57513  -5.72384  1.000 13.79121 ? 217 THR A N   1 
ATOM   1552 C  CA  . THR A 1 217 ? 18.42233 -4.58084  -5.43105  1.000 14.40809 ? 217 THR A CA  1 
ATOM   1553 C  C   . THR A 1 217 ? 17.53484 -4.75101  -6.65604  1.000 16.58266 ? 217 THR A C   1 
ATOM   1554 O  O   . THR A 1 217 ? 17.43206 -3.85498  -7.49738  1.000 17.60330 ? 217 THR A O   1 
ATOM   1555 C  CB  . THR A 1 217 ? 17.55416 -4.19289  -4.22279  1.000 15.45898 ? 217 THR A CB  1 
ATOM   1556 O  OG1 . THR A 1 217 ? 16.82618 -2.99520  -4.52169  1.000 14.44266 ? 217 THR A OG1 1 
ATOM   1557 C  CG2 . THR A 1 217 ? 18.40231 -3.96948  -2.97253  1.000 11.29746 ? 217 THR A CG2 1 
ATOM   1558 N  N   . ARG A 1 218 ? 16.89204 -5.91439  -6.75041  1.000 17.37300 ? 218 ARG A N   1 
ATOM   1559 C  CA  . ARG A 1 218 ? 15.87567 -6.13690  -7.77144  1.000 17.07837 ? 218 ARG A CA  1 
ATOM   1560 C  C   . ARG A 1 218 ? 15.05409 -7.36262  -7.40105  1.000 17.95307 ? 218 ARG A C   1 
ATOM   1561 O  O   . ARG A 1 218 ? 15.45619 -8.17850  -6.56701  1.000 15.16372 ? 218 ARG A O   1 
ATOM   1562 C  CB  . ARG A 1 218 ? 16.48463 -6.29934  -9.16917  1.000 15.41681 ? 218 ARG A CB  1 
ATOM   1563 C  CG  . ARG A 1 218 ? 17.20156 -7.61110  -9.40787  1.000 14.89675 ? 218 ARG A CG  1 
ATOM   1564 C  CD  . ARG A 1 218 ? 17.63775 -7.70807  -10.86222 1.000 13.73189 ? 218 ARG A CD  1 
ATOM   1565 N  NE  . ARG A 1 218 ? 18.43093 -6.55056  -11.26231 1.000 16.88160 ? 218 ARG A NE  1 
ATOM   1566 C  CZ  . ARG A 1 218 ? 18.88556 -6.33471  -12.48964 1.000 16.63553 ? 218 ARG A CZ  1 
ATOM   1567 N  NH1 . ARG A 1 218 ? 18.64199 -7.18153  -13.47637 1.000 17.50034 ? 218 ARG A NH1 1 
ATOM   1568 N  NH2 . ARG A 1 218 ? 19.60206 -5.24029  -12.73322 1.000 10.14784 ? 218 ARG A NH2 1 
ATOM   1569 N  N   . SER A 1 219 ? 13.89378 -7.47712  -8.04056  1.000 14.08277 ? 219 SER A N   1 
ATOM   1570 C  CA  . SER A 1 219 ? 12.93560 -8.54348  -7.77910  1.000 17.85112 ? 219 SER A CA  1 
ATOM   1571 C  C   . SER A 1 219 ? 12.91218 -9.49573  -8.96637  1.000 12.93349 ? 219 SER A C   1 
ATOM   1572 O  O   . SER A 1 219 ? 12.69482 -9.06687  -10.10437 1.000 15.74073 ? 219 SER A O   1 
ATOM   1573 C  CB  . SER A 1 219 ? 11.54125 -7.96988  -7.52660  1.000 14.01844 ? 219 SER A CB  1 
ATOM   1574 O  OG  . SER A 1 219 ? 10.58834 -9.00415  -7.36054  1.000 21.10005 ? 219 SER A OG  1 
ATOM   1575 N  N   . ILE A 1 220 ? 13.13994 -10.78220 -8.70134  1.000 14.49650 ? 220 ILE A N   1 
ATOM   1576 C  CA  . ILE A 1 220 ? 13.08903 -11.82359 -9.71979  1.000 16.29395 ? 220 ILE A CA  1 
ATOM   1577 C  C   . ILE A 1 220 ? 12.30680 -13.00566 -9.16108  1.000 16.62021 ? 220 ILE A C   1 
ATOM   1578 O  O   . ILE A 1 220 ? 11.95537 -13.04739 -7.98040  1.000 16.44938 ? 220 ILE A O   1 
ATOM   1579 C  CB  . ILE A 1 220 ? 14.49365 -12.26948 -10.17953 1.000 18.43266 ? 220 ILE A CB  1 
ATOM   1580 C  CG1 . ILE A 1 220 ? 15.34123 -12.68177 -8.97617  1.000 18.17707 ? 220 ILE A CG1 1 
ATOM   1581 C  CG2 . ILE A 1 220 ? 15.17837 -11.16133 -10.96865 1.000 20.26531 ? 220 ILE A CG2 1 
ATOM   1582 C  CD1 . ILE A 1 220 ? 16.74826 -13.10904 -9.33340  1.000 16.24416 ? 220 ILE A CD1 1 
ATOM   1583 N  N   . SER A 1 221 ? 12.03953 -13.97839 -10.02991 1.000 14.61972 ? 221 SER A N   1 
ATOM   1584 C  CA  . SER A 1 221 ? 11.18919 -15.10842 -9.69068  1.000 16.36441 ? 221 SER A CA  1 
ATOM   1585 C  C   . SER A 1 221 ? 11.83827 -16.40981 -10.13680 1.000 15.06826 ? 221 SER A C   1 
ATOM   1586 O  O   . SER A 1 221 ? 12.62641 -16.43985 -11.08588 1.000 18.42980 ? 221 SER A O   1 
ATOM   1587 C  CB  . SER A 1 221 ? 9.80410  -14.97784 -10.33628 1.000 12.92945 ? 221 SER A CB  1 
ATOM   1588 O  OG  . SER A 1 221 ? 9.20817  -13.73441 -10.01458 1.000 17.34796 ? 221 SER A OG  1 
ATOM   1589 N  N   . GLY A 1 222 ? 11.48795 -17.48112 -9.45064  1.000 15.32921 ? 222 GLY A N   1 
ATOM   1590 C  CA  . GLY A 1 222 ? 11.98753 -18.80554 -9.76123  1.000 16.59570 ? 222 GLY A CA  1 
ATOM   1591 C  C   . GLY A 1 222 ? 12.04104 -19.66181 -8.51517  1.000 15.84199 ? 222 GLY A C   1 
ATOM   1592 O  O   . GLY A 1 222 ? 11.98290 -19.18320 -7.38510  1.000 16.86263 ? 222 GLY A O   1 
ATOM   1593 N  N   . THR A 1 223 ? 12.14897 -20.97578 -8.72810  1.000 19.51329 ? 223 THR A N   1 
ATOM   1594 C  CA  . THR A 1 223 ? 12.43090 -21.86825 -7.60990  1.000 14.45500 ? 223 THR A CA  1 
ATOM   1595 C  C   . THR A 1 223 ? 13.81977 -21.61755 -7.03988  1.000 12.63910 ? 223 THR A C   1 
ATOM   1596 O  O   . THR A 1 223 ? 14.11260 -22.05273 -5.92064  1.000 11.91527 ? 223 THR A O   1 
ATOM   1597 C  CB  . THR A 1 223 ? 12.29954 -23.33193 -8.03836  1.000 14.93866 ? 223 THR A CB  1 
ATOM   1598 O  OG1 . THR A 1 223 ? 13.20652 -23.60431 -9.11534  1.000 17.10261 ? 223 THR A OG1 1 
ATOM   1599 C  CG2 . THR A 1 223 ? 10.87251 -23.63545 -8.48408  1.000 14.55969 ? 223 THR A CG2 1 
ATOM   1600 N  N   . SER A 1 224 ? 14.68168 -20.93119 -7.79585  1.000 13.06149 ? 224 SER A N   1 
ATOM   1601 C  CA  . SER A 1 224 ? 15.96176 -20.47929 -7.26903  1.000 16.19635 ? 224 SER A CA  1 
ATOM   1602 C  C   . SER A 1 224 ? 15.78744 -19.46903 -6.14564  1.000 15.55089 ? 224 SER A C   1 
ATOM   1603 O  O   . SER A 1 224 ? 16.70448 -19.28894 -5.33957  1.000 11.22686 ? 224 SER A O   1 
ATOM   1604 C  CB  . SER A 1 224 ? 16.81212 -19.86670 -8.38526  1.000 17.81016 ? 224 SER A CB  1 
ATOM   1605 O  OG  . SER A 1 224 ? 17.21767 -20.84574 -9.32300  1.000 21.52858 ? 224 SER A OG  1 
ATOM   1606 N  N   . MET A 1 225 ? 14.63872 -18.80226 -6.07821  1.000 14.94983 ? 225 MET A N   1 
ATOM   1607 C  CA  . MET A 1 225 ? 14.35746 -17.88036 -4.98603  1.000 10.25660 ? 225 MET A CA  1 
ATOM   1608 C  C   . MET A 1 225 ? 13.73624 -18.57435 -3.78184  1.000 11.55123 ? 225 MET A C   1 
ATOM   1609 O  O   . MET A 1 225 ? 13.88114 -18.09214 -2.64980  1.000 11.46202 ? 225 MET A O   1 
ATOM   1610 C  CB  . MET A 1 225 ? 13.42522 -16.75445 -5.45691  1.000 10.36118 ? 225 MET A CB  1 
ATOM   1611 C  CG  . MET A 1 225 ? 14.09265 -15.68822 -6.29792  1.000 16.26003 ? 225 MET A CG  1 
ATOM   1612 S  SD  . MET A 1 225 ? 14.73766 -16.30226 -7.86562  1.000 16.25333 ? 225 MET A SD  1 
ATOM   1613 C  CE  . MET A 1 225 ? 16.49918 -16.32720 -7.52586  1.000 14.25427 ? 225 MET A CE  1 
ATOM   1614 N  N   . ALA A 1 226 ? 13.03576 -19.68915 -3.99982  1.000 11.60148 ? 226 ALA A N   1 
ATOM   1615 C  CA  . ALA A 1 226 ? 12.39931 -20.38666 -2.88634  1.000 12.11681 ? 226 ALA A CA  1 
ATOM   1616 C  C   . ALA A 1 226 ? 13.41686 -21.16922 -2.06477  1.000 11.13808 ? 226 ALA A C   1 
ATOM   1617 O  O   . ALA A 1 226 ? 13.27190 -21.29464 -0.84230  1.000 14.05375 ? 226 ALA A O   1 
ATOM   1618 C  CB  . ALA A 1 226 ? 11.30244 -21.31669 -3.40226  1.000 11.26766 ? 226 ALA A CB  1 
ATOM   1619 N  N   . THR A 1 227 ? 14.45228 -21.69828 -2.71724  1.000 10.23623 ? 227 THR A N   1 
ATOM   1620 C  CA  . THR A 1 227 ? 15.44951 -22.50106 -2.01033  1.000 11.30396 ? 227 THR A CA  1 
ATOM   1621 C  C   . THR A 1 227 ? 16.16257 -21.73284 -0.90024  1.000 9.18189  ? 227 THR A C   1 
ATOM   1622 O  O   . THR A 1 227 ? 16.27285 -22.27399 0.21389   1.000 11.53105 ? 227 THR A O   1 
ATOM   1623 C  CB  . THR A 1 227 ? 16.44361 -23.08657 -3.02088  1.000 14.72185 ? 227 THR A CB  1 
ATOM   1624 O  OG1 . THR A 1 227 ? 15.73121 -23.83777 -4.01239  1.000 13.91352 ? 227 THR A OG1 1 
ATOM   1625 C  CG2 . THR A 1 227 ? 17.45318 -23.99257 -2.32270  1.000 12.39570 ? 227 THR A CG2 1 
ATOM   1626 N  N   . PRO A 1 228 ? 16.65852 -20.50317 -1.10699  1.000 12.03523 ? 228 PRO A N   1 
ATOM   1627 C  CA  . PRO A 1 228 ? 17.32222 -19.79903 0.00604   1.000 11.92519 ? 228 PRO A CA  1 
ATOM   1628 C  C   . PRO A 1 228 ? 16.40128 -19.49149 1.17370   1.000 12.35132 ? 228 PRO A C   1 
ATOM   1629 O  O   . PRO A 1 228 ? 16.88168 -19.34337 2.30554   1.000 12.76194 ? 228 PRO A O   1 
ATOM   1630 C  CB  . PRO A 1 228 ? 17.84648 -18.51448 -0.65352  1.000 11.82789 ? 228 PRO A CB  1 
ATOM   1631 C  CG  . PRO A 1 228 ? 17.02746 -18.33502 -1.86843  1.000 9.06474  ? 228 PRO A CG  1 
ATOM   1632 C  CD  . PRO A 1 228 ? 16.72707 -19.71654 -2.35122  1.000 15.91946 ? 228 PRO A CD  1 
ATOM   1633 N  N   . HIS A 1 229 ? 15.09423 -19.37097 0.93166   1.000 11.87971 ? 229 HIS A N   1 
ATOM   1634 C  CA  . HIS A 1 229 ? 14.14527 -19.25971 2.03448   1.000 14.41318 ? 229 HIS A CA  1 
ATOM   1635 C  C   . HIS A 1 229 ? 14.23036 -20.47616 2.94866   1.000 11.46530 ? 229 HIS A C   1 
ATOM   1636 O  O   . HIS A 1 229 ? 14.27974 -20.34433 4.17683   1.000 12.24318 ? 229 HIS A O   1 
ATOM   1637 C  CB  . HIS A 1 229 ? 12.72407 -19.09714 1.49237   1.000 12.59393 ? 229 HIS A CB  1 
ATOM   1638 C  CG  . HIS A 1 229 ? 12.40058 -17.70820 1.03864   1.000 15.63860 ? 229 HIS A CG  1 
ATOM   1639 N  ND1 . HIS A 1 229 ? 12.51374 -17.30597 -0.27488  1.000 13.59278 ? 229 HIS A ND1 1 
ATOM   1640 C  CD2 . HIS A 1 229 ? 11.96248 -16.62761 1.72654   1.000 18.71019 ? 229 HIS A CD2 1 
ATOM   1641 C  CE1 . HIS A 1 229 ? 12.15919 -16.03725 -0.37615  1.000 15.56998 ? 229 HIS A CE1 1 
ATOM   1642 N  NE2 . HIS A 1 229 ? 11.82050 -15.60204 0.82398   1.000 12.94624 ? 229 HIS A NE2 1 
ATOM   1643 N  N   . VAL A 1 230 ? 14.25492 -21.67445 2.36100   1.000 14.44128 ? 230 VAL A N   1 
ATOM   1644 C  CA  . VAL A 1 230 ? 14.32413 -22.89635 3.15591   1.000 13.80149 ? 230 VAL A CA  1 
ATOM   1645 C  C   . VAL A 1 230 ? 15.71550 -23.06808 3.75504   1.000 10.83494 ? 230 VAL A C   1 
ATOM   1646 O  O   . VAL A 1 230 ? 15.86084 -23.48872 4.90949   1.000 15.62262 ? 230 VAL A O   1 
ATOM   1647 C  CB  . VAL A 1 230 ? 13.91471 -24.10635 2.29594   1.000 12.50313 ? 230 VAL A CB  1 
ATOM   1648 C  CG1 . VAL A 1 230 ? 14.11871 -25.40640 3.06011   1.000 10.99699 ? 230 VAL A CG1 1 
ATOM   1649 C  CG2 . VAL A 1 230 ? 12.46906 -23.96785 1.85090   1.000 12.39204 ? 230 VAL A CG2 1 
ATOM   1650 N  N   . ALA A 1 231 ? 16.75873 -22.74169 2.98605   1.000 11.47763 ? 231 ALA A N   1 
ATOM   1651 C  CA  . ALA A 1 231 ? 18.11965 -22.81872 3.50915   1.000 9.71671  ? 231 ALA A CA  1 
ATOM   1652 C  C   . ALA A 1 231 ? 18.31464 -21.86700 4.68233   1.000 11.65846 ? 231 ALA A C   1 
ATOM   1653 O  O   . ALA A 1 231 ? 18.95615 -22.22038 5.67911   1.000 12.78516 ? 231 ALA A O   1 
ATOM   1654 C  CB  . ALA A 1 231 ? 19.12597 -22.51596 2.39933   1.000 12.72108 ? 231 ALA A CB  1 
ATOM   1655 N  N   . GLY A 1 232 ? 17.77433 -20.65136 4.57823   1.000 11.33766 ? 232 GLY A N   1 
ATOM   1656 C  CA  . GLY A 1 232 ? 17.87122 -19.71322 5.68412   1.000 11.00203 ? 232 GLY A CA  1 
ATOM   1657 C  C   . GLY A 1 232 ? 17.06757 -20.15091 6.89300   1.000 12.08406 ? 232 GLY A C   1 
ATOM   1658 O  O   . GLY A 1 232 ? 17.49669 -19.96832 8.03449   1.000 12.49229 ? 232 GLY A O   1 
ATOM   1659 N  N   . LEU A 1 233 ? 15.88807 -20.73157 6.65837   1.000 12.85449 ? 233 LEU A N   1 
ATOM   1660 C  CA  . LEU A 1 233 ? 15.06546 -21.22192 7.75948   1.000 12.66148 ? 233 LEU A CA  1 
ATOM   1661 C  C   . LEU A 1 233 ? 15.74561 -22.37366 8.48959   1.000 15.42228 ? 233 LEU A C   1 
ATOM   1662 O  O   . LEU A 1 233 ? 15.64012 -22.48599 9.71658   1.000 12.29423 ? 233 LEU A O   1 
ATOM   1663 C  CB  . LEU A 1 233 ? 13.69538 -21.65356 7.23725   1.000 13.47068 ? 233 LEU A CB  1 
ATOM   1664 C  CG  . LEU A 1 233 ? 12.72456 -22.18076 8.29830   1.000 15.47465 ? 233 LEU A CG  1 
ATOM   1665 C  CD1 . LEU A 1 233 ? 12.42963 -21.10219 9.32472   1.000 17.27211 ? 233 LEU A CD1 1 
ATOM   1666 C  CD2 . LEU A 1 233 ? 11.44140 -22.68889 7.65961   1.000 15.52997 ? 233 LEU A CD2 1 
ATOM   1667 N  N   . ALA A 1 234 ? 16.45207 -23.23624 7.75493   1.000 18.41677 ? 234 ALA A N   1 
ATOM   1668 C  CA  . ALA A 1 234 ? 17.15355 -24.34520 8.39401   1.000 17.46418 ? 234 ALA A CA  1 
ATOM   1669 C  C   . ALA A 1 234 ? 18.25249 -23.84105 9.32480   1.000 16.13657 ? 234 ALA A C   1 
ATOM   1670 O  O   . ALA A 1 234 ? 18.40741 -24.34267 10.44495  1.000 14.85344 ? 234 ALA A O   1 
ATOM   1671 C  CB  . ALA A 1 234 ? 17.72775 -25.28119 7.33056   1.000 12.62249 ? 234 ALA A CB  1 
ATOM   1672 N  N   . ALA A 1 235 ? 19.02404 -22.84480 8.87788   1.000 15.07606 ? 235 ALA A N   1 
ATOM   1673 C  CA  . ALA A 1 235 ? 20.05065 -22.25138 9.72941   1.000 19.94170 ? 235 ALA A CA  1 
ATOM   1674 C  C   . ALA A 1 235 ? 19.43721 -21.54517 10.93145  1.000 15.52546 ? 235 ALA A C   1 
ATOM   1675 O  O   . ALA A 1 235 ? 20.02546 -21.54255 12.01892  1.000 12.26867 ? 235 ALA A O   1 
ATOM   1676 C  CB  . ALA A 1 235 ? 20.90959 -21.27783 8.91606   1.000 10.75976 ? 235 ALA A CB  1 
ATOM   1677 N  N   . TYR A 1 236 ? 18.25654 -20.95163 10.75743  1.000 14.97938 ? 236 TYR A N   1 
ATOM   1678 C  CA  . TYR A 1 236 ? 17.58415 -20.28452 11.86798  1.000 15.16737 ? 236 TYR A CA  1 
ATOM   1679 C  C   . TYR A 1 236 ? 17.11948 -21.28903 12.91932  1.000 17.79861 ? 236 TYR A C   1 
ATOM   1680 O  O   . TYR A 1 236 ? 17.27136 -21.05506 14.12521  1.000 14.57494 ? 236 TYR A O   1 
ATOM   1681 C  CB  . TYR A 1 236 ? 16.41202 -19.46462 11.32599  1.000 15.07467 ? 236 TYR A CB  1 
ATOM   1682 C  CG  . TYR A 1 236 ? 15.41690 -18.97541 12.35588  1.000 17.46328 ? 236 TYR A CG  1 
ATOM   1683 C  CD1 . TYR A 1 236 ? 15.63184 -17.79792 13.06226  1.000 15.14113 ? 236 TYR A CD1 1 
ATOM   1684 C  CD2 . TYR A 1 236 ? 14.24104 -19.67482 12.59385  1.000 19.99042 ? 236 TYR A CD2 1 
ATOM   1685 C  CE1 . TYR A 1 236 ? 14.70907 -17.34269 13.99448  1.000 18.71434 ? 236 TYR A CE1 1 
ATOM   1686 C  CE2 . TYR A 1 236 ? 13.31369 -19.22927 13.52255  1.000 20.06737 ? 236 TYR A CE2 1 
ATOM   1687 C  CZ  . TYR A 1 236 ? 13.55243 -18.06237 14.21955  1.000 20.00752 ? 236 TYR A CZ  1 
ATOM   1688 O  OH  . TYR A 1 236 ? 12.62969 -17.61949 15.14120  1.000 17.07749 ? 236 TYR A OH  1 
ATOM   1689 N  N   . LEU A 1 237 ? 16.56345 -22.42060 12.48000  1.000 13.82281 ? 237 LEU A N   1 
ATOM   1690 C  CA  . LEU A 1 237 ? 16.09932 -23.43806 13.41809  1.000 13.65514 ? 237 LEU A CA  1 
ATOM   1691 C  C   . LEU A 1 237 ? 17.26020 -24.19454 14.05323  1.000 18.14126 ? 237 LEU A C   1 
ATOM   1692 O  O   . LEU A 1 237 ? 17.17477 -24.59200 15.22185  1.000 15.81904 ? 237 LEU A O   1 
ATOM   1693 C  CB  . LEU A 1 237 ? 15.15529 -24.41244 12.70932  1.000 14.17114 ? 237 LEU A CB  1 
ATOM   1694 C  CG  . LEU A 1 237 ? 13.83955 -23.82012 12.20026  1.000 15.48963 ? 237 LEU A CG  1 
ATOM   1695 C  CD1 . LEU A 1 237 ? 13.08666 -24.84242 11.36063  1.000 16.25293 ? 237 LEU A CD1 1 
ATOM   1696 C  CD2 . LEU A 1 237 ? 12.98845 -23.34400 13.36708  1.000 13.83338 ? 237 LEU A CD2 1 
ATOM   1697 N  N   . MET A 1 238 ? 18.34778 -24.40335 13.30790  1.000 15.83984 ? 238 MET A N   1 
ATOM   1698 C  CA  . MET A 1 238 ? 19.49573 -25.11329 13.86569  1.000 16.55241 ? 238 MET A CA  1 
ATOM   1699 C  C   . MET A 1 238 ? 20.18644 -24.28936 14.94609  1.000 18.82995 ? 238 MET A C   1 
ATOM   1700 O  O   . MET A 1 238 ? 20.67054 -24.83921 15.94379  1.000 19.83207 ? 238 MET A O   1 
ATOM   1701 C  CB  . MET A 1 238 ? 20.47700 -25.47557 12.75261  1.000 15.91866 ? 238 MET A CB  1 
ATOM   1702 C  CG  . MET A 1 238 ? 20.05591 -26.68595 11.93025  1.000 20.68670 ? 238 MET A CG  1 
ATOM   1703 S  SD  . MET A 1 238 ? 20.76539 -26.69951 10.27198  1.000 26.82379 ? 238 MET A SD  1 
ATOM   1704 C  CE  . MET A 1 238 ? 22.46600 -26.28060 10.62757  1.000 21.02732 ? 238 MET A CE  1 
ATOM   1705 N  N   . THR A 1 239 ? 20.24193 -22.96904 14.76451  1.000 15.37125 ? 239 THR A N   1 
ATOM   1706 C  CA  . THR A 1 239 ? 20.78736 -22.10435 15.80433  1.000 15.54558 ? 239 THR A CA  1 
ATOM   1707 C  C   . THR A 1 239 ? 19.93301 -22.16403 17.06498  1.000 16.47086 ? 239 THR A C   1 
ATOM   1708 O  O   . THR A 1 239 ? 20.46201 -22.20129 18.18309  1.000 15.64496 ? 239 THR A O   1 
ATOM   1709 C  CB  . THR A 1 239 ? 20.89961 -20.66891 15.28375  1.000 12.67699 ? 239 THR A CB  1 
ATOM   1710 O  OG1 . THR A 1 239 ? 21.97063 -20.58255 14.33351  1.000 14.77000 ? 239 THR A OG1 1 
ATOM   1711 C  CG2 . THR A 1 239 ? 21.16110 -19.69494 16.42481  1.000 17.07843 ? 239 THR A CG2 1 
ATOM   1712 N  N   . LEU A 1 240 ? 18.60759 -22.19737 16.90454  1.000 16.39351 ? 240 LEU A N   1 
ATOM   1713 C  CA  . LEU A 1 240 ? 17.71544 -22.32420 18.05055  1.000 16.13744 ? 240 LEU A CA  1 
ATOM   1714 C  C   . LEU A 1 240 ? 17.77003 -23.70494 18.69148  1.000 15.81794 ? 240 LEU A C   1 
ATOM   1715 O  O   . LEU A 1 240 ? 17.26209 -23.86952 19.80646  1.000 19.00352 ? 240 LEU A O   1 
ATOM   1716 C  CB  . LEU A 1 240 ? 16.27607 -22.00283 17.63799  1.000 16.27207 ? 240 LEU A CB  1 
ATOM   1717 C  CG  . LEU A 1 240 ? 15.93305 -20.52453 17.42924  1.000 18.35940 ? 240 LEU A CG  1 
ATOM   1718 C  CD1 . LEU A 1 240 ? 14.50637 -20.35946 16.92736  1.000 17.68915 ? 240 LEU A CD1 1 
ATOM   1719 C  CD2 . LEU A 1 240 ? 16.13865 -19.73909 18.71474  1.000 26.32974 ? 240 LEU A CD2 1 
ATOM   1720 N  N   . GLY A 1 241 ? 18.37067 -24.68905 18.02487  1.000 14.85628 ? 241 GLY A N   1 
ATOM   1721 C  CA  . GLY A 1 241 ? 18.44912 -26.02725 18.57154  1.000 16.62781 ? 241 GLY A CA  1 
ATOM   1722 C  C   . GLY A 1 241 ? 17.22930 -26.88437 18.34715  1.000 14.49407 ? 241 GLY A C   1 
ATOM   1723 O  O   . GLY A 1 241 ? 17.06993 -27.90143 19.02929  1.000 18.20447 ? 241 GLY A O   1 
ATOM   1724 N  N   . LYS A 1 242 ? 16.35412 -26.50776 17.41219  1.000 19.16329 ? 242 LYS A N   1 
ATOM   1725 C  CA  . LYS A 1 242 ? 15.13672 -27.28226 17.19963  1.000 15.77492 ? 242 LYS A CA  1 
ATOM   1726 C  C   . LYS A 1 242 ? 15.40987 -28.56569 16.42721  1.000 16.22278 ? 242 LYS A C   1 
ATOM   1727 O  O   . LYS A 1 242 ? 14.66528 -29.53925 16.57064  1.000 15.27390 ? 242 LYS A O   1 
ATOM   1728 C  CB  . LYS A 1 242 ? 14.10892 -26.43429 16.46147  1.000 20.23246 ? 242 LYS A CB  1 
ATOM   1729 C  CG  . LYS A 1 242 ? 13.80360 -25.10205 17.13699  1.000 21.88960 ? 242 LYS A CG  1 
ATOM   1730 C  CD  . LYS A 1 242 ? 12.90572 -25.27559 18.35201  1.000 25.71857 ? 242 LYS A CD  1 
ATOM   1731 C  CE  . LYS A 1 242 ? 12.46308 -23.92210 18.89241  1.000 29.70252 ? 242 LYS A CE  1 
ATOM   1732 N  NZ  . LYS A 1 242 ? 11.44845 -24.06680 19.96909  1.000 41.73991 ? 242 LYS A NZ  1 
ATOM   1733 N  N   . THR A 1 243 ? 16.46702 -28.59682 15.61976  1.000 15.73956 ? 243 THR A N   1 
ATOM   1734 C  CA  . THR A 1 243 ? 16.71989 -29.73051 14.73902  1.000 15.76189 ? 243 THR A CA  1 
ATOM   1735 C  C   . THR A 1 243 ? 18.20187 -29.76177 14.38759  1.000 17.67246 ? 243 THR A C   1 
ATOM   1736 O  O   . THR A 1 243 ? 18.97289 -28.87313 14.76339  1.000 17.82536 ? 243 THR A O   1 
ATOM   1737 C  CB  . THR A 1 243 ? 15.85641 -29.64926 13.47780  1.000 15.14300 ? 243 THR A CB  1 
ATOM   1738 O  OG1 . THR A 1 243 ? 16.06730 -30.81626 12.67257  1.000 16.13677 ? 243 THR A OG1 1 
ATOM   1739 C  CG2 . THR A 1 243 ? 16.22107 -28.40947 12.67682  1.000 17.15516 ? 243 THR A CG2 1 
ATOM   1740 N  N   . THR A 1 244 ? 18.59110 -30.80064 13.65567  1.000 16.76118 ? 244 THR A N   1 
ATOM   1741 C  CA  . THR A 1 244 ? 19.96123 -30.99455 13.21273  1.000 17.85026 ? 244 THR A CA  1 
ATOM   1742 C  C   . THR A 1 244 ? 20.00767 -30.97415 11.69185  1.000 16.48066 ? 244 THR A C   1 
ATOM   1743 O  O   . THR A 1 244 ? 18.97868 -30.90241 11.01763  1.000 18.09892 ? 244 THR A O   1 
ATOM   1744 C  CB  . THR A 1 244 ? 20.53596 -32.31329 13.74187  1.000 13.70723 ? 244 THR A CB  1 
ATOM   1745 O  OG1 . THR A 1 244 ? 19.81295 -33.41002 13.17507  1.000 17.69928 ? 244 THR A OG1 1 
ATOM   1746 C  CG2 . THR A 1 244 ? 20.41344 -32.37539 15.25366  1.000 21.31514 ? 244 THR A CG2 1 
ATOM   1747 N  N   . ALA A 1 245 ? 21.22692 -31.03554 11.15304  1.000 15.80542 ? 245 ALA A N   1 
ATOM   1748 C  CA  . ALA A 1 245 ? 21.39329 -31.03952 9.70305   1.000 14.91832 ? 245 ALA A CA  1 
ATOM   1749 C  C   . ALA A 1 245 ? 20.78500 -32.29012 9.07947   1.000 19.88221 ? 245 ALA A C   1 
ATOM   1750 O  O   . ALA A 1 245 ? 20.25851 -32.24522 7.96072   1.000 20.48775 ? 245 ALA A O   1 
ATOM   1751 C  CB  . ALA A 1 245 ? 22.87589 -30.92881 9.34914   1.000 21.99459 ? 245 ALA A CB  1 
ATOM   1752 N  N   . ALA A 1 246 ? 20.83714 -33.41515 9.79605   1.000 18.44379 ? 246 ALA A N   1 
ATOM   1753 C  CA  . ALA A 1 246 ? 20.33324 -34.67001 9.24945   1.000 18.31329 ? 246 ALA A CA  1 
ATOM   1754 C  C   . ALA A 1 246 ? 18.81188 -34.69166 9.17384   1.000 18.99319 ? 246 ALA A C   1 
ATOM   1755 O  O   . ALA A 1 246 ? 18.24821 -35.34441 8.28801   1.000 21.40122 ? 246 ALA A O   1 
ATOM   1756 C  CB  . ALA A 1 246 ? 20.83517 -35.84607 10.08775  1.000 16.43880 ? 246 ALA A CB  1 
ATOM   1757 N  N   . SER A 1 247 ? 18.13173 -33.98857 10.07984  1.000 13.22464 ? 247 SER A N   1 
ATOM   1758 C  CA  . SER A 1 247 ? 16.67790 -34.04839 10.17501  1.000 18.93444 ? 247 SER A CA  1 
ATOM   1759 C  C   . SER A 1 247 ? 16.00228 -32.69886 9.95878   1.000 16.85582 ? 247 SER A C   1 
ATOM   1760 O  O   . SER A 1 247 ? 14.81411 -32.56000 10.27440  1.000 15.83087 ? 247 SER A O   1 
ATOM   1761 C  CB  . SER A 1 247 ? 16.26783 -34.61593 11.53646  1.000 19.06448 ? 247 SER A CB  1 
ATOM   1762 O  OG  . SER A 1 247 ? 16.73511 -33.78715 12.58708  1.000 21.59627 ? 247 SER A OG  1 
ATOM   1763 N  N   . ALA A 1 248 ? 16.71681 -31.70371 9.42595   1.000 14.83143 ? 248 ALA A N   1 
ATOM   1764 C  CA  . ALA A 1 248 ? 16.13761 -30.36845 9.30057   1.000 11.82228 ? 248 ALA A CA  1 
ATOM   1765 C  C   . ALA A 1 248 ? 15.00038 -30.34531 8.28701   1.000 15.01283 ? 248 ALA A C   1 
ATOM   1766 O  O   . ALA A 1 248 ? 13.96340 -29.71510 8.52487   1.000 12.00606 ? 248 ALA A O   1 
ATOM   1767 C  CB  . ALA A 1 248 ? 17.21746 -29.35829 8.91563   1.000 13.76285 ? 248 ALA A CB  1 
ATOM   1768 N  N   . CYS A 1 249 ? 15.17772 -31.02609 7.15184   1.000 13.04950 ? 249 CYS A N   1 
ATOM   1769 C  CA  . CYS A 1 249 ? 14.14676 -31.04092 6.11815   1.000 14.44084 ? 249 CYS A CA  1 
ATOM   1770 C  C   . CYS A 1 249 ? 12.86162 -31.68249 6.62889   1.000 15.52946 ? 249 CYS A C   1 
ATOM   1771 O  O   . CYS A 1 249 ? 11.76136 -31.18302 6.36545   1.000 10.09508 ? 249 CYS A O   1 
ATOM   1772 C  CB  . CYS A 1 249 ? 14.66646 -31.77658 4.88158   1.000 13.62081 ? 249 CYS A CB  1 
ATOM   1773 S  SG  . CYS A 1 249 ? 13.61786 -31.67762 3.40631   1.000 14.25125 ? 249 CYS A SG  1 
ATOM   1774 N  N   . ARG A 1 250 ? 12.98097 -32.78903 7.36707   1.000 14.22565 ? 250 ARG A N   1 
ATOM   1775 C  CA  . ARG A 1 250 ? 11.79547 -33.45349 7.90047   1.000 14.04613 ? 250 ARG A CA  1 
ATOM   1776 C  C   . ARG A 1 250 ? 11.10655 -32.59249 8.95279   1.000 14.87257 ? 250 ARG A C   1 
ATOM   1777 O  O   . ARG A 1 250 ? 9.87235  -32.51905 8.99430   1.000 16.96191 ? 250 ARG A O   1 
ATOM   1778 C  CB  . ARG A 1 250 ? 12.17343 -34.81660 8.48223   1.000 17.00068 ? 250 ARG A CB  1 
ATOM   1779 N  N   . TYR A 1 251 ? 11.88848 -31.93547 9.81467   1.000 14.62387 ? 251 TYR A N   1 
ATOM   1780 C  CA  . TYR A 1 251 ? 11.30399 -31.06621 10.83159  1.000 15.07223 ? 251 TYR A CA  1 
ATOM   1781 C  C   . TYR A 1 251 ? 10.55935 -29.89954 10.19468  1.000 15.75394 ? 251 TYR A C   1 
ATOM   1782 O  O   . TYR A 1 251 ? 9.49653  -29.49270 10.67893  1.000 13.34861 ? 251 TYR A O   1 
ATOM   1783 C  CB  . TYR A 1 251 ? 12.39370 -30.56046 11.78008  1.000 17.01017 ? 251 TYR A CB  1 
ATOM   1784 C  CG  . TYR A 1 251 ? 11.89897 -29.58998 12.83143  1.000 17.71299 ? 251 TYR A CG  1 
ATOM   1785 C  CD1 . TYR A 1 251 ? 11.40513 -30.04447 14.04700  1.000 18.48988 ? 251 TYR A CD1 1 
ATOM   1786 C  CD2 . TYR A 1 251 ? 11.93038 -28.21965 12.60893  1.000 16.84205 ? 251 TYR A CD2 1 
ATOM   1787 C  CE1 . TYR A 1 251 ? 10.95166 -29.16205 15.00908  1.000 22.42677 ? 251 TYR A CE1 1 
ATOM   1788 C  CE2 . TYR A 1 251 ? 11.47940 -27.33091 13.56227  1.000 15.81008 ? 251 TYR A CE2 1 
ATOM   1789 C  CZ  . TYR A 1 251 ? 10.99077 -27.80572 14.76069  1.000 19.08169 ? 251 TYR A CZ  1 
ATOM   1790 O  OH  . TYR A 1 251 ? 10.54108 -26.92072 15.71417  1.000 20.70441 ? 251 TYR A OH  1 
ATOM   1791 N  N   . ILE A 1 252 ? 11.09932 -29.35240 9.10357   1.000 13.90787 ? 252 ILE A N   1 
ATOM   1792 C  CA  . ILE A 1 252 ? 10.44845 -28.23187 8.43221   1.000 9.79093  ? 252 ILE A CA  1 
ATOM   1793 C  C   . ILE A 1 252 ? 9.11564  -28.66709 7.83510   1.000 13.33628 ? 252 ILE A C   1 
ATOM   1794 O  O   . ILE A 1 252 ? 8.11385  -27.94641 7.92446   1.000 11.16586 ? 252 ILE A O   1 
ATOM   1795 C  CB  . ILE A 1 252 ? 11.38978 -27.63551 7.36927   1.000 11.71220 ? 252 ILE A CB  1 
ATOM   1796 C  CG1 . ILE A 1 252 ? 12.54190 -26.88601 8.04465   1.000 14.65517 ? 252 ILE A CG1 1 
ATOM   1797 C  CG2 . ILE A 1 252 ? 10.63028 -26.71752 6.42430   1.000 12.46300 ? 252 ILE A CG2 1 
ATOM   1798 C  CD1 . ILE A 1 252 ? 13.57629 -26.34963 7.07891   1.000 16.25856 ? 252 ILE A CD1 1 
ATOM   1799 N  N   . ALA A 1 253 ? 9.07594  -29.85530 7.22886   1.000 10.99510 ? 253 ALA A N   1 
ATOM   1800 C  CA  . ALA A 1 253 ? 7.81580  -30.36812 6.70339   1.000 10.61286 ? 253 ALA A CA  1 
ATOM   1801 C  C   . ALA A 1 253 ? 6.84239  -30.68969 7.82987   1.000 17.18626 ? 253 ALA A C   1 
ATOM   1802 O  O   . ALA A 1 253 ? 5.63049  -30.49176 7.68526   1.000 16.19259 ? 253 ALA A O   1 
ATOM   1803 C  CB  . ALA A 1 253 ? 8.06841  -31.60365 5.83990   1.000 10.17415 ? 253 ALA A CB  1 
ATOM   1804 N  N   . ASP A 1 254 ? 7.35569  -31.18112 8.96185   1.000 12.20285 ? 254 ASP A N   1 
ATOM   1805 C  CA  . ASP A 1 254 ? 6.49047  -31.51189 10.08996  1.000 13.95035 ? 254 ASP A CA  1 
ATOM   1806 C  C   . ASP A 1 254 ? 5.79042  -30.28004 10.64748  1.000 19.22705 ? 254 ASP A C   1 
ATOM   1807 O  O   . ASP A 1 254 ? 4.64908  -30.37415 11.11261  1.000 18.03735 ? 254 ASP A O   1 
ATOM   1808 C  CB  . ASP A 1 254 ? 7.29899  -32.19855 11.19329  1.000 14.17544 ? 254 ASP A CB  1 
ATOM   1809 C  CG  . ASP A 1 254 ? 7.51449  -33.67520 10.92826  1.000 21.08009 ? 254 ASP A CG  1 
ATOM   1810 O  OD1 . ASP A 1 254 ? 6.93041  -34.19813 9.95560   1.000 18.82917 ? 254 ASP A OD1 1 
ATOM   1811 O  OD2 . ASP A 1 254 ? 8.26597  -34.31521 11.69364  1.000 21.73407 ? 254 ASP A OD2 1 
ATOM   1812 N  N   . THR A 1 255 ? 6.44834  -29.12201 10.60416  1.000 13.65641 ? 255 THR A N   1 
ATOM   1813 C  CA  . THR A 1 255 ? 5.94567  -27.90306 11.22483  1.000 16.68083 ? 255 THR A CA  1 
ATOM   1814 C  C   . THR A 1 255 ? 5.48398  -26.86673 10.20814  1.000 17.06185 ? 255 THR A C   1 
ATOM   1815 O  O   . THR A 1 255 ? 5.28015  -25.70278 10.57002  1.000 17.68448 ? 255 THR A O   1 
ATOM   1816 C  CB  . THR A 1 255 ? 7.02021  -27.30052 12.12904  1.000 17.79849 ? 255 THR A CB  1 
ATOM   1817 O  OG1 . THR A 1 255 ? 8.16543  -26.95196 11.33986  1.000 16.58845 ? 255 THR A OG1 1 
ATOM   1818 C  CG2 . THR A 1 255 ? 7.43163  -28.30590 13.19361  1.000 19.09213 ? 255 THR A CG2 1 
ATOM   1819 N  N   . ALA A 1 256 ? 5.30756  -27.25911 8.95194   1.000 16.33474 ? 256 ALA A N   1 
ATOM   1820 C  CA  . ALA A 1 256 ? 4.92923  -26.32298 7.90833   1.000 15.36580 ? 256 ALA A CA  1 
ATOM   1821 C  C   . ALA A 1 256 ? 3.43100  -26.02312 7.96217   1.000 20.06932 ? 256 ALA A C   1 
ATOM   1822 O  O   . ALA A 1 256 ? 2.65101  -26.71222 8.62536   1.000 14.42728 ? 256 ALA A O   1 
ATOM   1823 C  CB  . ALA A 1 256 ? 5.31232  -26.88051 6.53901   1.000 14.93653 ? 256 ALA A CB  1 
ATOM   1824 N  N   . ASN A 1 257 ? 3.03266  -24.96566 7.25675   1.000 17.41808 ? 257 ASN A N   1 
ATOM   1825 C  CA  . ASN A 1 257 ? 1.61568  -24.70743 7.03514   1.000 19.93693 ? 257 ASN A CA  1 
ATOM   1826 C  C   . ASN A 1 257 ? 1.07164  -25.71362 6.02826   1.000 22.12009 ? 257 ASN A C   1 
ATOM   1827 O  O   . ASN A 1 257 ? 1.60793  -25.85344 4.92497   1.000 17.36919 ? 257 ASN A O   1 
ATOM   1828 C  CB  . ASN A 1 257 ? 1.40132  -23.27778 6.53753   1.000 17.91382 ? 257 ASN A CB  1 
ATOM   1829 C  CG  . ASN A 1 257 ? 1.37729  -22.26287 7.66615   1.000 22.00073 ? 257 ASN A CG  1 
ATOM   1830 O  OD1 . ASN A 1 257 ? 0.66654  -22.43619 8.65610   1.000 19.06252 ? 257 ASN A OD1 1 
ATOM   1831 N  ND2 . ASN A 1 257 ? 2.15573  -21.19628 7.52156   1.000 18.43153 ? 257 ASN A ND2 1 
ATOM   1832 N  N   . LYS A 1 258 ? 0.01312  -26.42330 6.40785   1.000 20.53702 ? 258 LYS A N   1 
ATOM   1833 C  CA  . LYS A 1 258 ? -0.47582 -27.56208 5.64202   1.000 25.98548 ? 258 LYS A CA  1 
ATOM   1834 C  C   . LYS A 1 258 ? -1.81239 -27.23210 4.99370   1.000 20.95247 ? 258 LYS A C   1 
ATOM   1835 O  O   . LYS A 1 258 ? -2.75125 -26.80513 5.67497   1.000 20.57515 ? 258 LYS A O   1 
ATOM   1836 C  CB  . LYS A 1 258 ? -0.60405 -28.79654 6.53658   1.000 20.68863 ? 258 LYS A CB  1 
ATOM   1837 C  CG  . LYS A 1 258 ? 0.57366  -28.95343 7.48017   1.000 26.79549 ? 258 LYS A CG  1 
ATOM   1838 C  CD  . LYS A 1 258 ? 0.85218  -30.39752 7.83610   1.000 32.24619 ? 258 LYS A CD  1 
ATOM   1839 C  CE  . LYS A 1 258 ? 2.22668  -30.51196 8.46796   1.000 34.53769 ? 258 LYS A CE  1 
ATOM   1840 N  NZ  . LYS A 1 258 ? 2.33498  -29.64280 9.67205   1.000 28.71245 ? 258 LYS A NZ  1 
ATOM   1841 N  N   . GLY A 1 259 ? -1.89042 -27.43433 3.67810   1.000 20.87130 ? 259 GLY A N   1 
ATOM   1842 C  CA  . GLY A 1 259 ? -3.12190 -27.26418 2.93813   1.000 22.16926 ? 259 GLY A CA  1 
ATOM   1843 C  C   . GLY A 1 259 ? -3.41792 -25.85711 2.47091   1.000 21.63340 ? 259 GLY A C   1 
ATOM   1844 O  O   . GLY A 1 259 ? -4.47856 -25.63530 1.87344   1.000 18.98252 ? 259 GLY A O   1 
ATOM   1845 N  N   . ASP A 1 260 ? -2.52147 -24.90096 2.71262   1.000 19.02280 ? 260 ASP A N   1 
ATOM   1846 C  CA  . ASP A 1 260 ? -2.77844 -23.51006 2.36107   1.000 17.10694 ? 260 ASP A CA  1 
ATOM   1847 C  C   . ASP A 1 260 ? -2.59544 -23.21371 0.87871   1.000 21.58674 ? 260 ASP A C   1 
ATOM   1848 O  O   . ASP A 1 260 ? -2.97746 -22.12578 0.43429   1.000 26.39840 ? 260 ASP A O   1 
ATOM   1849 C  CB  . ASP A 1 260 ? -1.86766 -22.58389 3.17267   1.000 22.86105 ? 260 ASP A CB  1 
ATOM   1850 C  CG  . ASP A 1 260 ? -2.28172 -22.48822 4.62550   1.000 25.77241 ? 260 ASP A CG  1 
ATOM   1851 O  OD1 . ASP A 1 260 ? -3.32532 -23.07238 4.98397   1.000 27.28944 ? 260 ASP A OD1 1 
ATOM   1852 O  OD2 . ASP A 1 260 ? -1.56731 -21.82943 5.40982   1.000 20.24905 ? 260 ASP A OD2 1 
ATOM   1853 N  N   . LEU A 1 261 ? -2.03807 -24.13925 0.10640   1.000 19.87294 ? 261 LEU A N   1 
ATOM   1854 C  CA  . LEU A 1 261 ? -1.64788 -23.86798 -1.26882  1.000 18.01409 ? 261 LEU A CA  1 
ATOM   1855 C  C   . LEU A 1 261 ? -2.70041 -24.37460 -2.24866  1.000 19.07070 ? 261 LEU A C   1 
ATOM   1856 O  O   . LEU A 1 261 ? -3.40577 -25.35120 -1.98416  1.000 20.54813 ? 261 LEU A O   1 
ATOM   1857 C  CB  . LEU A 1 261 ? -0.29177 -24.50707 -1.58197  1.000 19.96066 ? 261 LEU A CB  1 
ATOM   1858 C  CG  . LEU A 1 261 ? 0.99232  -23.76613 -1.18025  1.000 22.68659 ? 261 LEU A CG  1 
ATOM   1859 C  CD1 . LEU A 1 261 ? 1.01626  -23.36068 0.29228   1.000 23.71409 ? 261 LEU A CD1 1 
ATOM   1860 C  CD2 . LEU A 1 261 ? 2.20142  -24.62522 -1.51037  1.000 20.75420 ? 261 LEU A CD2 1 
ATOM   1861 N  N   . SER A 1 262 ? -2.80026 -23.69331 -3.38786  1.000 18.17843 ? 262 SER A N   1 
ATOM   1862 C  CA  . SER A 1 262 ? -3.72165 -24.06304 -4.45003  1.000 15.83714 ? 262 SER A CA  1 
ATOM   1863 C  C   . SER A 1 262 ? -2.94327 -24.41861 -5.71075  1.000 19.43250 ? 262 SER A C   1 
ATOM   1864 O  O   . SER A 1 262 ? -1.75619 -24.10548 -5.84323  1.000 14.68860 ? 262 SER A O   1 
ATOM   1865 C  CB  . SER A 1 262 ? -4.72040 -22.93400 -4.74566  1.000 22.60248 ? 262 SER A CB  1 
ATOM   1866 O  OG  . SER A 1 262 ? -4.06420 -21.77737 -5.23052  1.000 26.68064 ? 262 SER A OG  1 
ATOM   1867 N  N   . ASN A 1 263 ? -3.63862 -25.08141 -6.63862  1.000 17.44568 ? 263 ASN A N   1 
ATOM   1868 C  CA  . ASN A 1 263 ? -3.04613 -25.56974 -7.88593  1.000 21.61193 ? 263 ASN A CA  1 
ATOM   1869 C  C   . ASN A 1 263 ? -1.89865 -26.53985 -7.60594  1.000 22.06831 ? 263 ASN A C   1 
ATOM   1870 O  O   . ASN A 1 263 ? -0.87875 -26.55042 -8.29858  1.000 22.88386 ? 263 ASN A O   1 
ATOM   1871 C  CB  . ASN A 1 263 ? -2.58943 -24.41054 -8.77709  1.000 19.83331 ? 263 ASN A CB  1 
ATOM   1872 C  CG  . ASN A 1 263 ? -2.25547 -24.85487 -10.19039 1.000 31.23281 ? 263 ASN A CG  1 
ATOM   1873 O  OD1 . ASN A 1 263 ? -1.40538 -24.26353 -10.85516 1.000 32.36046 ? 263 ASN A OD1 1 
ATOM   1874 N  ND2 . ASN A 1 263 ? -2.91446 -25.91318 -10.64913 1.000 40.06408 ? 263 ASN A ND2 1 
ATOM   1875 N  N   . ILE A 1 264 ? -2.06376 -27.35808 -6.57326  1.000 18.12046 ? 264 ILE A N   1 
ATOM   1876 C  CA  . ILE A 1 264 ? -1.11723 -28.42157 -6.25543  1.000 18.47758 ? 264 ILE A CA  1 
ATOM   1877 C  C   . ILE A 1 264 ? -1.64238 -29.71070 -6.88151  1.000 19.25399 ? 264 ILE A C   1 
ATOM   1878 O  O   . ILE A 1 264 ? -2.73885 -30.15916 -6.51109  1.000 18.64860 ? 264 ILE A O   1 
ATOM   1879 C  CB  . ILE A 1 264 ? -0.93224 -28.58355 -4.74210  1.000 23.74546 ? 264 ILE A CB  1 
ATOM   1880 C  CG1 . ILE A 1 264 ? -0.40503 -27.28661 -4.12439  1.000 22.63075 ? 264 ILE A CG1 1 
ATOM   1881 C  CG2 . ILE A 1 264 ? 0.01527  -29.73927 -4.44123  1.000 18.10910 ? 264 ILE A CG2 1 
ATOM   1882 C  CD1 . ILE A 1 264 ? 0.94951  -26.86561 -4.64890  1.000 19.00207 ? 264 ILE A CD1 1 
ATOM   1883 N  N   . PRO A 1 265 ? -0.92423 -30.31428 -7.82446  1.000 22.40714 ? 265 PRO A N   1 
ATOM   1884 C  CA  . PRO A 1 265 ? -1.40147 -31.56574 -8.41996  1.000 14.23886 ? 265 PRO A CA  1 
ATOM   1885 C  C   . PRO A 1 265 ? -1.40174 -32.69283 -7.40097  1.000 22.39727 ? 265 PRO A C   1 
ATOM   1886 O  O   . PRO A 1 265 ? -0.65298 -32.67651 -6.42054  1.000 22.19641 ? 265 PRO A O   1 
ATOM   1887 C  CB  . PRO A 1 265 ? -0.39426 -31.83438 -9.54603  1.000 23.31930 ? 265 PRO A CB  1 
ATOM   1888 C  CG  . PRO A 1 265 ? 0.29342  -30.51929 -9.78089  1.000 19.58912 ? 265 PRO A CG  1 
ATOM   1889 C  CD  . PRO A 1 265 ? 0.32204  -29.84381 -8.44857  1.000 18.21255 ? 265 PRO A CD  1 
ATOM   1890 N  N   . PHE A 1 266 ? -2.26163 -33.67994 -7.64485  1.000 24.76481 ? 266 PHE A N   1 
ATOM   1891 C  CA  . PHE A 1 266 ? -2.34621 -34.83048 -6.75664  1.000 27.07532 ? 266 PHE A CA  1 
ATOM   1892 C  C   . PHE A 1 266 ? -1.02484 -35.58928 -6.74547  1.000 18.17794 ? 266 PHE A C   1 
ATOM   1893 O  O   . PHE A 1 266 ? -0.41857 -35.83385 -7.79235  1.000 22.12010 ? 266 PHE A O   1 
ATOM   1894 C  CB  . PHE A 1 266 ? -3.48684 -35.75072 -7.19208  1.000 32.54903 ? 266 PHE A CB  1 
ATOM   1895 C  CG  . PHE A 1 266 ? -3.84808 -36.79258 -6.17112  1.000 24.46351 ? 266 PHE A CG  1 
ATOM   1896 C  CD1 . PHE A 1 266 ? -4.57437 -36.45191 -5.04046  1.000 28.02574 ? 266 PHE A CD1 1 
ATOM   1897 C  CD2 . PHE A 1 266 ? -3.46766 -38.11221 -6.34335  1.000 27.04204 ? 266 PHE A CD2 1 
ATOM   1898 C  CE1 . PHE A 1 266 ? -4.90929 -37.40909 -4.09698  1.000 25.82854 ? 266 PHE A CE1 1 
ATOM   1899 C  CE2 . PHE A 1 266 ? -3.79954 -39.07401 -5.40578  1.000 24.18815 ? 266 PHE A CE2 1 
ATOM   1900 C  CZ  . PHE A 1 266 ? -4.52092 -38.72220 -4.28070  1.000 22.35034 ? 266 PHE A CZ  1 
ATOM   1901 N  N   . GLY A 1 267 ? -0.57520 -35.95643 -5.54769  1.000 18.13839 ? 267 GLY A N   1 
ATOM   1902 C  CA  . GLY A 1 267 ? 0.70264  -36.60923 -5.37008  1.000 20.84849 ? 267 GLY A CA  1 
ATOM   1903 C  C   . GLY A 1 267 ? 1.82107  -35.69369 -4.92075  1.000 15.96608 ? 267 GLY A C   1 
ATOM   1904 O  O   . GLY A 1 267 ? 2.88926  -36.18919 -4.54056  1.000 16.66092 ? 267 GLY A O   1 
ATOM   1905 N  N   . THR A 1 268 ? 1.61034  -34.38125 -4.95809  1.000 18.15098 ? 268 THR A N   1 
ATOM   1906 C  CA  . THR A 1 268 ? 2.58266  -33.40672 -4.48564  1.000 15.00167 ? 268 THR A CA  1 
ATOM   1907 C  C   . THR A 1 268 ? 2.16704  -32.89863 -3.11204  1.000 15.95510 ? 268 THR A C   1 
ATOM   1908 O  O   . THR A 1 268 ? 0.98623  -32.63110 -2.87022  1.000 13.52485 ? 268 THR A O   1 
ATOM   1909 C  CB  . THR A 1 268 ? 2.69944  -32.23193 -5.46033  1.000 15.00612 ? 268 THR A CB  1 
ATOM   1910 O  OG1 . THR A 1 268 ? 2.97678  -32.72508 -6.77662  1.000 14.38968 ? 268 THR A OG1 1 
ATOM   1911 C  CG2 . THR A 1 268 ? 3.81394  -31.28412 -5.03420  1.000 12.65662 ? 268 THR A CG2 1 
ATOM   1912 N  N   . VAL A 1 269 ? 3.14487  -32.76928 -2.21228  1.000 14.44635 ? 269 VAL A N   1 
ATOM   1913 C  CA  . VAL A 1 269 ? 2.84436  -32.30365 -0.86697  1.000 15.48770 ? 269 VAL A CA  1 
ATOM   1914 C  C   . VAL A 1 269 ? 2.30629  -30.87622 -0.91419  1.000 15.72247 ? 269 VAL A C   1 
ATOM   1915 O  O   . VAL A 1 269 ? 2.68095  -30.06795 -1.77395  1.000 18.18236 ? 269 VAL A O   1 
ATOM   1916 C  CB  . VAL A 1 269 ? 4.08396  -32.39171 0.04005   1.000 15.21094 ? 269 VAL A CB  1 
ATOM   1917 C  CG1 . VAL A 1 269 ? 4.52159  -33.83978 0.20135   1.000 22.52901 ? 269 VAL A CG1 1 
ATOM   1918 C  CG2 . VAL A 1 269 ? 5.22041  -31.53947 -0.51611  1.000 15.83034 ? 269 VAL A CG2 1 
ATOM   1919 N  N   . ASN A 1 270 ? 1.40116  -30.57254 0.01199   1.000 11.51786 ? 270 ASN A N   1 
ATOM   1920 C  CA  . ASN A 1 270 ? 0.84929  -29.23163 0.18445   1.000 15.90263 ? 270 ASN A CA  1 
ATOM   1921 C  C   . ASN A 1 270 ? 1.38896  -28.69857 1.50951   1.000 16.84347 ? 270 ASN A C   1 
ATOM   1922 O  O   . ASN A 1 270 ? 0.68867  -28.65323 2.52144   1.000 15.00801 ? 270 ASN A O   1 
ATOM   1923 C  CB  . ASN A 1 270 ? -0.69071 -29.25677 0.14962   1.000 16.51717 ? 270 ASN A CB  1 
ATOM   1924 C  CG  . ASN A 1 270 ? -1.29802 -27.87099 0.00946   1.000 15.35173 ? 270 ASN A CG  1 
ATOM   1925 O  OD1 . ASN A 1 270 ? -0.75664 -26.88696 0.51219   1.000 17.84962 ? 270 ASN A OD1 1 
ATOM   1926 N  ND2 . ASN A 1 270 ? -2.43122 -27.78985 -0.67953  1.000 18.56958 ? 270 ASN A ND2 1 
ATOM   1927 N  N   . LEU A 1 271 ? 2.66192  -28.30474 1.49536   1.000 13.03627 ? 271 LEU A N   1 
ATOM   1928 C  CA  . LEU A 1 271 ? 3.37689  -27.87913 2.69240   1.000 14.95677 ? 271 LEU A CA  1 
ATOM   1929 C  C   . LEU A 1 271 ? 4.14111  -26.60127 2.38745   1.000 17.20035 ? 271 LEU A C   1 
ATOM   1930 O  O   . LEU A 1 271 ? 4.81012  -26.51170 1.35433   1.000 12.23951 ? 271 LEU A O   1 
ATOM   1931 C  CB  . LEU A 1 271 ? 4.34377  -28.96777 3.17104   1.000 14.67378 ? 271 LEU A CB  1 
ATOM   1932 C  CG  . LEU A 1 271 ? 3.70543  -30.32009 3.49122   1.000 18.60070 ? 271 LEU A CG  1 
ATOM   1933 C  CD1 . LEU A 1 271 ? 4.77007  -31.38833 3.70015   1.000 13.79813 ? 271 LEU A CD1 1 
ATOM   1934 C  CD2 . LEU A 1 271 ? 2.79389  -30.20780 4.70231   1.000 16.38647 ? 271 LEU A CD2 1 
ATOM   1935 N  N   . LEU A 1 272 ? 4.04981  -25.62282 3.28720   1.000 15.56549 ? 272 LEU A N   1 
ATOM   1936 C  CA  . LEU A 1 272 ? 4.66553  -24.31353 3.09603   1.000 14.68272 ? 272 LEU A CA  1 
ATOM   1937 C  C   . LEU A 1 272 ? 5.52720  -23.98854 4.30656   1.000 14.10912 ? 272 LEU A C   1 
ATOM   1938 O  O   . LEU A 1 272 ? 5.03468  -24.00388 5.43903   1.000 12.65557 ? 272 LEU A O   1 
ATOM   1939 C  CB  . LEU A 1 272 ? 3.60016  -23.23342 2.88973   1.000 15.51760 ? 272 LEU A CB  1 
ATOM   1940 C  CG  . LEU A 1 272 ? 4.09176  -21.81317 2.60772   1.000 13.55661 ? 272 LEU A CG  1 
ATOM   1941 C  CD1 . LEU A 1 272 ? 4.92162  -21.77238 1.33483   1.000 13.15122 ? 272 LEU A CD1 1 
ATOM   1942 C  CD2 . LEU A 1 272 ? 2.91377  -20.85069 2.52205   1.000 15.36547 ? 272 LEU A CD2 1 
ATOM   1943 N  N   . ALA A 1 273 ? 6.80236  -23.67839 4.06312   1.000 13.75699 ? 273 ALA A N   1 
ATOM   1944 C  CA  . ALA A 1 273 ? 7.75575  -23.44853 5.14412   1.000 17.09718 ? 273 ALA A CA  1 
ATOM   1945 C  C   . ALA A 1 273 ? 7.25807  -22.37446 6.10542   1.000 14.51007 ? 273 ALA A C   1 
ATOM   1946 O  O   . ALA A 1 273 ? 6.68193  -21.36438 5.69343   1.000 14.93611 ? 273 ALA A O   1 
ATOM   1947 C  CB  . ALA A 1 273 ? 9.11755  -23.05193 4.56977   1.000 14.70179 ? 273 ALA A CB  1 
ATOM   1948 N  N   . TYR A 1 274 ? 7.49306  -22.60169 7.39716   1.000 16.01485 ? 274 TYR A N   1 
ATOM   1949 C  CA  . TYR A 1 274 ? 6.91988  -21.77621 8.45109   1.000 15.67151 ? 274 TYR A CA  1 
ATOM   1950 C  C   . TYR A 1 274 ? 7.78920  -21.90886 9.69395   1.000 16.42194 ? 274 TYR A C   1 
ATOM   1951 O  O   . TYR A 1 274 ? 8.18190  -23.01915 10.05901  1.000 18.52452 ? 274 TYR A O   1 
ATOM   1952 C  CB  . TYR A 1 274 ? 5.47261  -22.20282 8.73366   1.000 15.56881 ? 274 TYR A CB  1 
ATOM   1953 C  CG  . TYR A 1 274 ? 4.82073  -21.53565 9.92075   1.000 16.76845 ? 274 TYR A CG  1 
ATOM   1954 C  CD1 . TYR A 1 274 ? 4.75834  -20.15271 10.01896  1.000 19.25776 ? 274 TYR A CD1 1 
ATOM   1955 C  CD2 . TYR A 1 274 ? 4.23844  -22.29260 10.92995  1.000 21.33925 ? 274 TYR A CD2 1 
ATOM   1956 C  CE1 . TYR A 1 274 ? 4.15366  -19.54120 11.10175  1.000 15.96067 ? 274 TYR A CE1 1 
ATOM   1957 C  CE2 . TYR A 1 274 ? 3.62954  -21.69196 12.01345  1.000 20.75718 ? 274 TYR A CE2 1 
ATOM   1958 C  CZ  . TYR A 1 274 ? 3.59011  -20.31709 12.09589  1.000 19.58475 ? 274 TYR A CZ  1 
ATOM   1959 O  OH  . TYR A 1 274 ? 2.98569  -19.71369 13.17487  1.000 21.38642 ? 274 TYR A OH  1 
ATOM   1960 N  N   . ASN A 1 275 ? 8.08703  -20.77768 10.33836  1.000 16.22622 ? 275 ASN A N   1 
ATOM   1961 C  CA  . ASN A 1 275 ? 9.05043  -20.76445 11.43408  1.000 18.12619 ? 275 ASN A CA  1 
ATOM   1962 C  C   . ASN A 1 275 ? 8.42026  -20.93497 12.81137  1.000 14.73329 ? 275 ASN A C   1 
ATOM   1963 O  O   . ASN A 1 275 ? 9.15875  -21.06267 13.79409  1.000 17.88975 ? 275 ASN A O   1 
ATOM   1964 C  CB  . ASN A 1 275 ? 9.87934  -19.47028 11.40810  1.000 14.01967 ? 275 ASN A CB  1 
ATOM   1965 C  CG  . ASN A 1 275 ? 9.05296  -18.22404 11.69019  1.000 18.30592 ? 275 ASN A CG  1 
ATOM   1966 O  OD1 . ASN A 1 275 ? 7.84257  -18.28762 11.90581  1.000 15.22118 ? 275 ASN A OD1 1 
ATOM   1967 N  ND2 . ASN A 1 275 ? 9.71851  -17.07487 11.69664  1.000 15.67620 ? 275 ASN A ND2 1 
ATOM   1968 N  N   . ASN A 1 276 ? 7.08958  -20.92024 12.90995  1.000 15.83295 ? 276 ASN A N   1 
ATOM   1969 C  CA  . ASN A 1 276 ? 6.38922  -21.19067 14.16891  1.000 19.78354 ? 276 ASN A CA  1 
ATOM   1970 C  C   . ASN A 1 276 ? 6.81619  -20.23121 15.27862  1.000 20.83139 ? 276 ASN A C   1 
ATOM   1971 O  O   . ASN A 1 276 ? 6.86904  -20.60171 16.45373  1.000 15.28369 ? 276 ASN A O   1 
ATOM   1972 C  CB  . ASN A 1 276 ? 6.59104  -22.64365 14.60678  1.000 20.51787 ? 276 ASN A CB  1 
ATOM   1973 C  CG  . ASN A 1 276 ? 5.80394  -23.62211 13.76243  1.000 23.14535 ? 276 ASN A CG  1 
ATOM   1974 O  OD1 . ASN A 1 276 ? 6.28176  -24.09713 12.73291  1.000 30.21099 ? 276 ASN A OD1 1 
ATOM   1975 N  ND2 . ASN A 1 276 ? 4.59004  -23.93746 14.20120  1.000 27.74951 ? 276 ASN A ND2 1 
ATOM   1976 N  N   . TYR A 1 277 ? 7.12208  -18.98600 14.91863  1.000 18.97320 ? 277 TYR A N   1 
ATOM   1977 C  CA  . TYR A 1 277 ? 7.55791  -18.01791 15.91710  1.000 22.06979 ? 277 TYR A CA  1 
ATOM   1978 C  C   . TYR A 1 277 ? 6.38170  -17.58141 16.77993  1.000 22.46035 ? 277 TYR A C   1 
ATOM   1979 O  O   . TYR A 1 277 ? 5.33728  -17.16786 16.26620  1.000 27.55804 ? 277 TYR A O   1 
ATOM   1980 C  CB  . TYR A 1 277 ? 8.20299  -16.79701 15.25774  1.000 20.64319 ? 277 TYR A CB  1 
ATOM   1981 C  CG  . TYR A 1 277 ? 8.60930  -15.72850 16.25699  1.000 23.95250 ? 277 TYR A CG  1 
ATOM   1982 C  CD1 . TYR A 1 277 ? 9.81088  -15.81665 16.94877  1.000 22.33182 ? 277 TYR A CD1 1 
ATOM   1983 C  CD2 . TYR A 1 277 ? 7.78657  -14.63806 16.51431  1.000 26.66545 ? 277 TYR A CD2 1 
ATOM   1984 C  CE1 . TYR A 1 277 ? 10.18177 -14.84855 17.86435  1.000 26.43449 ? 277 TYR A CE1 1 
ATOM   1985 C  CE2 . TYR A 1 277 ? 8.15029  -13.66551 17.42726  1.000 26.40294 ? 277 TYR A CE2 1 
ATOM   1986 C  CZ  . TYR A 1 277 ? 9.34771  -13.77636 18.09989  1.000 27.18837 ? 277 TYR A CZ  1 
ATOM   1987 O  OH  . TYR A 1 277 ? 9.70978  -12.80811 19.00908  1.000 35.42267 ? 277 TYR A OH  1 
ATOM   1988 N  N   . GLN A 1 278 ? 6.56103  -17.67089 18.09548  1.000 18.39754 ? 278 GLN A N   1 
ATOM   1989 C  CA  . GLN A 1 278 ? 5.59071  -17.18677 19.06795  1.000 31.75551 ? 278 GLN A CA  1 
ATOM   1990 C  C   . GLN A 1 278 ? 6.31858  -16.26729 20.03479  1.000 32.98770 ? 278 GLN A C   1 
ATOM   1991 O  O   . GLN A 1 278 ? 7.23562  -16.70571 20.73754  1.000 34.45761 ? 278 GLN A O   1 
ATOM   1992 C  CB  . GLN A 1 278 ? 4.92517  -18.34589 19.81601  1.000 32.09798 ? 278 GLN A CB  1 
ATOM   1993 N  N   . ALA A 1 279 ? 5.92233  -14.99839 20.05938  1.000 31.95467 ? 279 ALA A N   1 
ATOM   1994 C  CA  . ALA A 1 279 ? 6.55781  -14.01495 20.92938  1.000 35.09621 ? 279 ALA A CA  1 
ATOM   1995 C  C   . ALA A 1 279 ? 6.37779  -14.38896 22.39753  1.000 39.30655 ? 279 ALA A C   1 
ATOM   1996 O  O   . ALA A 1 279 ? 7.30953  -14.29586 23.19709  1.000 39.66113 ? 279 ALA A O   1 
ATOM   1997 C  CB  . ALA A 1 279 ? 5.99522  -12.62590 20.66191  1.000 29.00139 ? 279 ALA A CB  1 
ATOM   1998 O  OXT . ALA A 1 279 ? 5.29704  -14.80349 22.81552  1.000 37.24014 ? 279 ALA A OXT 1 
HETATM 1999 CA CA  . CA  B 2 .   ? 13.77484 -35.22159 0.01268   1.000 13.61460 ? 501 CA  A CA  1 
HETATM 2000 CA CA  . CA  C 2 .   ? -3.20324 -21.20280 6.93324   1.000 26.24302 ? 502 CA  A CA  1 
HETATM 2001 N  N   . NO3 D 3 .   ? 33.22075 -16.25715 -15.74017 1.000 42.89475 ? 503 NO3 A N   1 
HETATM 2002 O  O1  . NO3 D 3 .   ? 34.30887 -15.68304 -15.87229 1.000 43.57203 ? 503 NO3 A O1  1 
HETATM 2003 O  O2  . NO3 D 3 .   ? 32.82998 -16.59818 -14.61831 1.000 34.87608 ? 503 NO3 A O2  1 
HETATM 2004 O  O3  . NO3 D 3 .   ? 32.51758 -16.49224 -16.72917 1.000 42.47514 ? 503 NO3 A O3  1 
HETATM 2005 O  O   . HOH E 4 .   ? 31.985   -35.987   -2.033    1.000 29.38235 ? 601 HOH A O   1 
HETATM 2006 O  O   . HOH E 4 .   ? 10.02065 -33.66951 -15.48007 1.000 31.53868 ? 602 HOH A O   1 
HETATM 2007 O  O   . HOH E 4 .   ? 34.77440 -35.05662 -6.95348  1.000 26.54232 ? 603 HOH A O   1 
HETATM 2008 O  O   . HOH E 4 .   ? 29.72656 -34.45454 -3.23869  1.000 23.74936 ? 604 HOH A O   1 
HETATM 2009 O  O   . HOH E 4 .   ? 14.96364 -20.68310 -10.81770 1.000 31.21764 ? 605 HOH A O   1 
HETATM 2010 O  O   . HOH E 4 .   ? 9.26248  -9.99949  -10.27901 1.000 29.08082 ? 606 HOH A O   1 
HETATM 2011 O  O   . HOH E 4 .   ? -0.99398 -35.54028 -9.96089  1.000 29.01558 ? 607 HOH A O   1 
HETATM 2012 O  O   . HOH E 4 .   ? -4.36441 -25.21028 5.77332   1.000 35.43646 ? 608 HOH A O   1 
HETATM 2013 O  O   . HOH E 4 .   ? 35.40142 -15.12687 -13.87871 1.000 26.37846 ? 609 HOH A O   1 
HETATM 2014 O  O   . HOH E 4 .   ? 22.48783 -19.05304 -18.03624 1.000 39.17447 ? 610 HOH A O   1 
HETATM 2015 O  O   . HOH E 4 .   ? 39.46207 -22.04250 2.79332   1.000 41.23815 ? 611 HOH A O   1 
HETATM 2016 O  O   . HOH E 4 .   ? 28.53724 -18.80130 -20.87304 1.000 34.27182 ? 612 HOH A O   1 
HETATM 2017 O  O   . HOH E 4 .   ? 9.41585  -37.11685 -1.60431  1.000 34.32427 ? 613 HOH A O   1 
HETATM 2018 O  O   . HOH E 4 .   ? 1.93088  -13.29029 5.24592   1.000 17.80003 ? 614 HOH A O   1 
HETATM 2019 O  O   . HOH E 4 .   ? 29.75080 -7.98715  -7.98031  1.000 21.97504 ? 615 HOH A O   1 
HETATM 2020 O  O   . HOH E 4 .   ? 19.64785 -41.55138 -2.13381  1.000 24.24785 ? 616 HOH A O   1 
HETATM 2021 O  O   . HOH E 4 .   ? 20.68617 -20.75101 -3.21601  1.000 14.62510 ? 617 HOH A O   1 
HETATM 2022 O  O   . HOH E 4 .   ? 8.70902  -36.60595 -8.59160  1.000 28.74258 ? 618 HOH A O   1 
HETATM 2023 O  O   . HOH E 4 .   ? -1.77593 -22.64712 8.19463   1.000 22.93605 ? 619 HOH A O   1 
HETATM 2024 O  O   . HOH E 4 .   ? 9.23243  -33.35536 13.78600  1.000 33.90673 ? 620 HOH A O   1 
HETATM 2025 O  O   . HOH E 4 .   ? -0.83176 -21.88355 -10.35222 1.000 26.25047 ? 621 HOH A O   1 
HETATM 2026 O  O   . HOH E 4 .   ? -3.50138 -12.48300 7.20436   1.000 29.74020 ? 622 HOH A O   1 
HETATM 2027 O  O   . HOH E 4 .   ? 27.04998 -16.67438 12.87889  1.000 26.60599 ? 623 HOH A O   1 
HETATM 2028 O  O   . HOH E 4 .   ? 3.42147  -11.06145 -7.05991  1.000 25.62628 ? 624 HOH A O   1 
HETATM 2029 O  O   . HOH E 4 .   ? 2.28546  -34.68225 -8.24742  1.000 22.42633 ? 625 HOH A O   1 
HETATM 2030 O  O   . HOH E 4 .   ? 0.39628  -25.59322 2.69814   1.000 18.26737 ? 626 HOH A O   1 
HETATM 2031 O  O   . HOH E 4 .   ? 4.33395  -20.38630 5.91468   1.000 21.51221 ? 627 HOH A O   1 
HETATM 2032 O  O   . HOH E 4 .   ? 22.01509 -8.50935  10.63553  1.000 19.57312 ? 628 HOH A O   1 
HETATM 2033 O  O   . HOH E 4 .   ? 17.66634 -29.18384 -8.69986  1.000 19.95930 ? 629 HOH A O   1 
HETATM 2034 O  O   . HOH E 4 .   ? 30.85871 -9.49292  3.46741   1.000 24.45579 ? 630 HOH A O   1 
HETATM 2035 O  O   . HOH E 4 .   ? 28.83822 -3.62470  -3.41975  1.000 18.00461 ? 631 HOH A O   1 
HETATM 2036 O  O   . HOH E 4 .   ? 16.69567 -13.49235 11.20751  1.000 19.14688 ? 632 HOH A O   1 
HETATM 2037 O  O   . HOH E 4 .   ? 12.23680 -9.21045  -12.64909 1.000 21.56537 ? 633 HOH A O   1 
HETATM 2038 O  O   . HOH E 4 .   ? 9.62253  -24.62305 14.94837  1.000 22.32707 ? 634 HOH A O   1 
HETATM 2039 O  O   . HOH E 4 .   ? 14.61054 -34.68199 -2.37159  1.000 11.93628 ? 635 HOH A O   1 
HETATM 2040 O  O   . HOH E 4 .   ? 30.86148 -9.88488  -7.28351  1.000 22.79409 ? 636 HOH A O   1 
HETATM 2041 O  O   . HOH E 4 .   ? 31.75968 -35.03794 7.63536   1.000 23.08858 ? 637 HOH A O   1 
HETATM 2042 O  O   . HOH E 4 .   ? 5.47876  -37.74808 -9.19054  1.000 18.21994 ? 638 HOH A O   1 
HETATM 2043 O  O   . HOH E 4 .   ? 8.04847  -25.11335 8.48065   1.000 10.77628 ? 639 HOH A O   1 
HETATM 2044 O  O   . HOH E 4 .   ? 9.24174  -24.43617 12.00365  1.000 16.08965 ? 640 HOH A O   1 
HETATM 2045 O  O   . HOH E 4 .   ? 38.15134 -32.29240 5.24371   1.000 17.87297 ? 641 HOH A O   1 
HETATM 2046 O  O   . HOH E 4 .   ? -4.02499 -19.79701 1.90692   1.000 22.65221 ? 642 HOH A O   1 
HETATM 2047 O  O   . HOH E 4 .   ? 3.03101  -18.52115 -0.59732  1.000 13.46928 ? 643 HOH A O   1 
HETATM 2048 O  O   . HOH E 4 .   ? 18.328   -8.610    13.357    1.000 33.01781 ? 644 HOH A O   1 
HETATM 2049 O  O   . HOH E 4 .   ? 11.80815 -36.29654 -1.57971  1.000 17.74669 ? 645 HOH A O   1 
HETATM 2050 O  O   . HOH E 4 .   ? 18.11213 -18.39851 15.13367  1.000 15.28558 ? 646 HOH A O   1 
HETATM 2051 O  O   . HOH E 4 .   ? 10.66469 -19.39492 15.40634  1.000 19.24802 ? 647 HOH A O   1 
HETATM 2052 O  O   . HOH E 4 .   ? 16.92878 -33.97960 3.25384   1.000 15.62947 ? 648 HOH A O   1 
HETATM 2053 O  O   . HOH E 4 .   ? 16.51686 -15.23972 -3.74218  1.000 17.29787 ? 649 HOH A O   1 
HETATM 2054 O  O   . HOH E 4 .   ? -4.51876 -19.58268 -3.55024  1.000 20.89141 ? 650 HOH A O   1 
HETATM 2055 O  O   . HOH E 4 .   ? 22.72821 -21.47357 -5.28494  1.000 12.13821 ? 651 HOH A O   1 
HETATM 2056 O  O   . HOH E 4 .   ? 0.85773  -13.05009 1.22514   1.000 26.07157 ? 652 HOH A O   1 
HETATM 2057 O  O   . HOH E 4 .   ? 20.22572 -41.17200 -9.01177  1.000 31.57208 ? 653 HOH A O   1 
HETATM 2058 O  O   . HOH E 4 .   ? 29.20136 -37.97526 -8.16752  1.000 16.74238 ? 654 HOH A O   1 
HETATM 2059 O  O   . HOH E 4 .   ? 9.28756  -9.56670  -2.63088  1.000 15.38128 ? 655 HOH A O   1 
HETATM 2060 O  O   . HOH E 4 .   ? 3.79990  -12.50470 9.37422   1.000 24.05785 ? 656 HOH A O   1 
HETATM 2061 O  O   . HOH E 4 .   ? 5.69534  -33.80327 -2.86272  1.000 16.34340 ? 657 HOH A O   1 
HETATM 2062 O  O   . HOH E 4 .   ? 39.32214 -28.83792 1.76546   1.000 21.60266 ? 658 HOH A O   1 
HETATM 2063 O  O   . HOH E 4 .   ? 30.81808 -2.00740  1.62977   1.000 27.38813 ? 659 HOH A O   1 
HETATM 2064 O  O   . HOH E 4 .   ? 12.99548 -29.38321 -19.73618 1.000 29.53097 ? 660 HOH A O   1 
HETATM 2065 O  O   . HOH E 4 .   ? 1.16672  -14.51377 -8.63538  1.000 24.50092 ? 661 HOH A O   1 
HETATM 2066 O  O   . HOH E 4 .   ? 27.74912 -18.34723 -4.99408  1.000 13.43406 ? 662 HOH A O   1 
HETATM 2067 O  O   . HOH E 4 .   ? 14.47498 -40.09221 -11.39146 1.000 24.18101 ? 663 HOH A O   1 
HETATM 2068 O  O   . HOH E 4 .   ? 22.63916 -41.42237 -8.10043  1.000 25.01057 ? 664 HOH A O   1 
HETATM 2069 O  O   . HOH E 4 .   ? 1.46724  -7.12045  8.71286   1.000 30.15131 ? 665 HOH A O   1 
HETATM 2070 O  O   . HOH E 4 .   ? 14.44771 -11.86618 -0.11737  1.000 12.82371 ? 666 HOH A O   1 
HETATM 2071 O  O   . HOH E 4 .   ? 9.59267  -11.51692 -0.78282  1.000 14.78848 ? 667 HOH A O   1 
HETATM 2072 O  O   . HOH E 4 .   ? 26.01172 -29.27291 10.18283  1.000 15.12469 ? 668 HOH A O   1 
HETATM 2073 O  O   . HOH E 4 .   ? 28.40983 -18.45313 12.20003  1.000 25.74786 ? 669 HOH A O   1 
HETATM 2074 O  O   . HOH E 4 .   ? 14.52264 -2.69845  -6.12380  1.000 30.00700 ? 670 HOH A O   1 
HETATM 2075 O  O   . HOH E 4 .   ? 12.57464 -17.44586 10.74590  1.000 18.21088 ? 671 HOH A O   1 
HETATM 2076 O  O   . HOH E 4 .   ? 24.04467 -2.73978  8.51592   1.000 31.67307 ? 672 HOH A O   1 
HETATM 2077 O  O   . HOH E 4 .   ? 0.82988  -18.68030 -9.57869  1.000 23.35475 ? 673 HOH A O   1 
HETATM 2078 O  O   . HOH E 4 .   ? 9.38417  -9.42269  19.00592  1.000 32.84576 ? 674 HOH A O   1 
HETATM 2079 O  O   . HOH E 4 .   ? 35.05902 -12.41675 -0.33861  1.000 21.05098 ? 675 HOH A O   1 
HETATM 2080 O  O   . HOH E 4 .   ? 27.20245 -30.64909 -17.91942 1.000 28.30617 ? 676 HOH A O   1 
HETATM 2081 O  O   . HOH E 4 .   ? 37.70323 -28.65116 -6.19534  1.000 19.07304 ? 677 HOH A O   1 
HETATM 2082 O  O   . HOH E 4 .   ? 33.72937 -13.09195 -12.46733 1.000 26.10028 ? 678 HOH A O   1 
HETATM 2083 O  O   . HOH E 4 .   ? 31.89228 -27.50102 10.63195  1.000 27.77897 ? 679 HOH A O   1 
HETATM 2084 O  O   . HOH E 4 .   ? 19.55436 -37.23189 6.58646   1.000 30.72903 ? 680 HOH A O   1 
HETATM 2085 O  O   . HOH E 4 .   ? 17.82057 -32.19768 6.47063   1.000 14.06228 ? 681 HOH A O   1 
HETATM 2086 O  O   . HOH E 4 .   ? 8.75123  -34.80875 -16.81967 1.000 31.42846 ? 682 HOH A O   1 
HETATM 2087 O  O   . HOH E 4 .   ? -3.33084 -31.65255 -4.14356  1.000 37.35941 ? 683 HOH A O   1 
HETATM 2088 O  O   . HOH E 4 .   ? 34.41746 -34.30254 0.00000   0.50  19.32603 ? 684 HOH A O   1 
HETATM 2089 O  O   . HOH E 4 .   ? 7.67626  -33.53513 2.83621   1.000 9.38892  ? 685 HOH A O   1 
HETATM 2090 O  O   . HOH E 4 .   ? 22.31366 -40.87692 -5.26484  1.000 20.96228 ? 686 HOH A O   1 
HETATM 2091 O  O   . HOH E 4 .   ? 20.67681 -7.63489  12.41973  1.000 28.48915 ? 687 HOH A O   1 
HETATM 2092 O  O   . HOH E 4 .   ? 19.386   -4.189    -9.903    1.000 19.09335 ? 688 HOH A O   1 
HETATM 2093 O  O   . HOH E 4 .   ? 20.47984 -21.48057 -11.72776 1.000 21.95951 ? 689 HOH A O   1 
HETATM 2094 O  O   . HOH E 4 .   ? 32.24176 -25.14494 -15.89770 1.000 21.90110 ? 690 HOH A O   1 
HETATM 2095 O  O   . HOH E 4 .   ? 4.56471  -4.00127  8.62596   1.000 27.40521 ? 691 HOH A O   1 
HETATM 2096 O  O   . HOH E 4 .   ? 22.97621 -33.98154 7.35368   1.000 29.43751 ? 692 HOH A O   1 
HETATM 2097 O  O   . HOH E 4 .   ? 15.59234 -2.09884  -8.87974  1.000 27.87902 ? 693 HOH A O   1 
HETATM 2098 O  O   . HOH E 4 .   ? 17.12308 -30.22714 -10.67806 1.000 32.85341 ? 694 HOH A O   1 
HETATM 2099 O  O   . HOH E 4 .   ? 15.02223 -33.50610 -18.25993 1.000 21.63448 ? 695 HOH A O   1 
HETATM 2100 O  O   . HOH E 4 .   ? 28.34548 0.00652   -7.21123  1.000 32.06323 ? 696 HOH A O   1 
HETATM 2101 O  O   . HOH E 4 .   ? 23.66075 -9.13362  -14.84400 1.000 23.90200 ? 697 HOH A O   1 
HETATM 2102 O  O   . HOH E 4 .   ? -1.65912 -11.76478 -0.75589  1.000 33.78298 ? 698 HOH A O   1 
HETATM 2103 O  O   . HOH E 4 .   ? 32.37520 -25.94851 13.75227  1.000 25.76298 ? 699 HOH A O   1 
HETATM 2104 O  O   . HOH E 4 .   ? 13.09044 -5.10032  -9.52274  1.000 18.42715 ? 700 HOH A O   1 
HETATM 2105 O  O   . HOH E 4 .   ? 31.38291 -15.65997 6.50090   1.000 21.17691 ? 701 HOH A O   1 
HETATM 2106 O  O   . HOH E 4 .   ? 34.34457 -33.53050 -11.04108 1.000 23.42228 ? 702 HOH A O   1 
HETATM 2107 O  O   . HOH E 4 .   ? 39.170   -29.150   12.468    1.000 27.65538 ? 703 HOH A O   1 
HETATM 2108 O  O   . HOH E 4 .   ? 0.38609  -32.37125 2.09634   1.000 23.04557 ? 704 HOH A O   1 
HETATM 2109 O  O   . HOH E 4 .   ? -6.13516 -23.93425 5.01664   1.000 34.50095 ? 705 HOH A O   1 
HETATM 2110 O  O   . HOH E 4 .   ? 22.36418 -38.78376 1.52330   1.000 19.98712 ? 706 HOH A O   1 
HETATM 2111 O  O   . HOH E 4 .   ? 40.81618 -18.00938 -10.26159 1.000 33.54557 ? 707 HOH A O   1 
HETATM 2112 O  O   . HOH E 4 .   ? 4.05922  -17.25653 -10.37039 1.000 17.37633 ? 708 HOH A O   1 
HETATM 2113 O  O   . HOH E 4 .   ? 4.18200  -13.15953 -5.74902  1.000 15.42792 ? 709 HOH A O   1 
HETATM 2114 O  O   . HOH E 4 .   ? 2.09692  -29.56052 -16.05197 1.000 29.49670 ? 710 HOH A O   1 
HETATM 2115 O  O   . HOH E 4 .   ? 18.25960 -31.71764 3.57687   1.000 13.51252 ? 711 HOH A O   1 
HETATM 2116 O  O   . HOH E 4 .   ? 19.03629 -40.51480 -7.20884  1.000 24.33610 ? 712 HOH A O   1 
HETATM 2117 O  O   . HOH E 4 .   ? 28.44808 -30.43872 9.80224   1.000 31.12296 ? 713 HOH A O   1 
HETATM 2118 O  O   . HOH E 4 .   ? 18.29476 -37.42356 4.40552   1.000 21.39998 ? 714 HOH A O   1 
HETATM 2119 O  O   . HOH E 4 .   ? 37.103   -23.167   -15.814   1.000 30.42310 ? 715 HOH A O   1 
HETATM 2120 O  O   . HOH E 4 .   ? 11.72188 -12.63948 0.58341   1.000 13.83061 ? 716 HOH A O   1 
HETATM 2121 O  O   . HOH E 4 .   ? 15.77576 -34.40040 6.92831   1.000 24.15807 ? 717 HOH A O   1 
HETATM 2122 O  O   . HOH E 4 .   ? 30.41481 -1.38971  -0.59657  1.000 36.90595 ? 718 HOH A O   1 
HETATM 2123 O  O   . HOH E 4 .   ? 14.28408 -35.22031 2.51360   1.000 18.66421 ? 719 HOH A O   1 
HETATM 2124 O  O   . HOH E 4 .   ? 13.79390 -6.28995  12.69363  1.000 25.56356 ? 720 HOH A O   1 
HETATM 2125 O  O   . HOH E 4 .   ? 0.37527  -16.50227 12.27072  1.000 29.72868 ? 721 HOH A O   1 
HETATM 2126 O  O   . HOH E 4 .   ? 2.80199  -8.54155  1.81911   1.000 32.84314 ? 722 HOH A O   1 
HETATM 2127 O  O   . HOH E 4 .   ? 39.81004 -23.47205 -9.43281  1.000 30.49634 ? 723 HOH A O   1 
HETATM 2128 O  O   . HOH E 4 .   ? -0.43338 -22.38908 -13.00965 1.000 28.64256 ? 724 HOH A O   1 
HETATM 2129 O  O   . HOH E 4 .   ? 21.69195 -5.30633  11.89354  1.000 28.02535 ? 725 HOH A O   1 
HETATM 2130 O  O   . HOH E 4 .   ? -5.14919 -23.03152 7.39062   1.000 37.45989 ? 726 HOH A O   1 
HETATM 2131 O  O   . HOH E 4 .   ? 22.91146 -40.67349 -15.32964 1.000 19.67078 ? 727 HOH A O   1 
HETATM 2132 O  O   . HOH E 4 .   ? 12.55742 -13.29490 -12.93908 1.000 27.59391 ? 728 HOH A O   1 
HETATM 2133 O  O   . HOH E 4 .   ? 26.51102 -40.79999 -2.70037  1.000 25.44020 ? 729 HOH A O   1 
HETATM 2134 O  O   . HOH E 4 .   ? 14.80661 -25.09002 -14.43135 1.000 28.79554 ? 730 HOH A O   1 
HETATM 2135 O  O   . HOH E 4 .   ? 3.00160  -12.60517 3.01030   1.000 21.12286 ? 731 HOH A O   1 
HETATM 2136 O  O   . HOH E 4 .   ? 3.23044  -5.07381  12.89016  1.000 29.29111 ? 732 HOH A O   1 
HETATM 2137 O  O   . HOH E 4 .   ? 7.96315  -22.74873 -17.02801 1.000 20.06836 ? 733 HOH A O   1 
HETATM 2138 O  O   . HOH E 4 .   ? 1.02379  -23.35552 -14.52684 1.000 27.46766 ? 734 HOH A O   1 
HETATM 2139 O  O   . HOH E 4 .   ? 23.10584 -33.68374 11.83832  1.000 28.98422 ? 735 HOH A O   1 
HETATM 2140 O  O   . HOH E 4 .   ? 16.35773 -23.45020 -10.69896 1.000 29.22906 ? 736 HOH A O   1 
HETATM 2141 O  O   . HOH E 4 .   ? 12.47213 -37.16795 1.26212   1.000 14.88047 ? 737 HOH A O   1 
HETATM 2142 O  O   . HOH E 4 .   ? -4.18556 -27.70165 -4.35053  1.000 29.10243 ? 738 HOH A O   1 
HETATM 2143 O  O   . HOH E 4 .   ? 42.62692 -17.14840 -11.72836 1.000 31.84782 ? 739 HOH A O   1 
HETATM 2144 O  O   . HOH E 4 .   ? 25.53205 -39.70545 -14.57398 1.000 26.83286 ? 740 HOH A O   1 
HETATM 2145 O  O   . HOH E 4 .   ? 17.62702 -1.03236  -8.77256  1.000 29.15617 ? 741 HOH A O   1 
HETATM 2146 O  O   . HOH E 4 .   ? -5.04258 -20.89022 -1.52598  1.000 30.08978 ? 742 HOH A O   1 
HETATM 2147 O  O   . HOH E 4 .   ? 39.38869 -20.18499 -5.59237  1.000 14.74397 ? 743 HOH A O   1 
HETATM 2148 O  O   . HOH E 4 .   ? 17.16101 -9.95834  -13.79038 1.000 24.46937 ? 744 HOH A O   1 
HETATM 2149 O  O   . HOH E 4 .   ? 14.724   -7.019    19.515    1.000 33.19917 ? 745 HOH A O   1 
HETATM 2150 O  O   . HOH E 4 .   ? 22.65423 -38.29772 3.89791   1.000 26.18955 ? 746 HOH A O   1 
HETATM 2151 O  O   . HOH E 4 .   ? 30.39281 -32.03240 -17.31410 1.000 28.71933 ? 747 HOH A O   1 
HETATM 2152 O  O   . HOH E 4 .   ? 14.20427 -32.21996 14.89753  1.000 28.20656 ? 748 HOH A O   1 
HETATM 2153 O  O   . HOH E 4 .   ? 35.90277 -18.59380 8.10785   1.000 38.99199 ? 749 HOH A O   1 
HETATM 2154 O  O   . HOH E 4 .   ? -5.20026 -11.72849 3.08557   1.000 33.90274 ? 750 HOH A O   1 
HETATM 2155 O  O   . HOH E 4 .   ? -4.08282 -20.44184 9.32498   1.000 33.10359 ? 751 HOH A O   1 
HETATM 2156 O  O   . HOH E 4 .   ? 12.06361 -3.39631  5.95087   1.000 27.83806 ? 752 HOH A O   1 
HETATM 2157 O  O   . HOH E 4 .   ? 24.00046 -30.50176 12.74940  1.000 22.03608 ? 753 HOH A O   1 
HETATM 2158 O  O   . HOH E 4 .   ? 22.40904 -10.89216 -15.62706 1.000 39.03292 ? 754 HOH A O   1 
HETATM 2159 O  O   . HOH E 4 .   ? -4.38314 -19.61276 5.60892   1.000 21.69005 ? 755 HOH A O   1 
HETATM 2160 O  O   . HOH E 4 .   ? 39.55997 -26.58582 2.20439   1.000 29.06539 ? 756 HOH A O   1 
HETATM 2161 O  O   . HOH E 4 .   ? 41.36972 -28.54056 3.59586   1.000 32.20140 ? 757 HOH A O   1 
HETATM 2162 O  O   . HOH E 4 .   ? 32.98858 -8.27512  -3.50512  1.000 23.30188 ? 758 HOH A O   1 
HETATM 2163 O  O   . HOH E 4 .   ? 7.63145  -7.39239  -1.35232  1.000 24.65014 ? 759 HOH A O   1 
HETATM 2164 O  O   . HOH E 4 .   ? 3.57886  -5.76834  -5.55278  1.000 33.33033 ? 760 HOH A O   1 
HETATM 2165 O  O   . HOH E 4 .   ? 15.92729 -28.38823 -11.42198 1.000 24.15355 ? 761 HOH A O   1 
HETATM 2166 O  O   . HOH E 4 .   ? 17.49398 -21.94949 -12.58428 1.000 35.83901 ? 762 HOH A O   1 
HETATM 2167 O  O   . HOH E 4 .   ? 36.63211 -13.08650 -15.68955 1.000 31.68016 ? 763 HOH A O   1 
HETATM 2168 O  O   . HOH E 4 .   ? 26.00332 -40.80723 0.33558   1.000 25.92741 ? 764 HOH A O   1 
HETATM 2169 O  O   . HOH E 4 .   ? 21.19809 -23.81575 -13.39509 1.000 27.25790 ? 765 HOH A O   1 
HETATM 2170 O  O   . HOH E 4 .   ? 15.89536 -27.60978 -13.95802 1.000 28.46142 ? 766 HOH A O   1 
HETATM 2171 O  O   . HOH E 4 .   ? 12.76730 -34.98934 4.62233   1.000 29.20073 ? 767 HOH A O   1 
HETATM 2172 O  O   . HOH E 4 .   ? 16.69982 -25.61015 -11.51859 1.000 30.77293 ? 768 HOH A O   1 
HETATM 2173 O  O   . HOH E 4 .   ? 7.28910  -35.48084 1.12125   1.000 33.01087 ? 769 HOH A O   1 
HETATM 2174 O  O   . HOH E 4 .   ? 5.21280  -16.07988 -12.58786 1.000 33.03866 ? 770 HOH A O   1 
HETATM 2175 O  O   . HOH E 4 .   ? 32.51706 -25.60196 16.18086  1.000 34.82657 ? 771 HOH A O   1 
HETATM 2176 O  O   . HOH E 4 .   ? 2.05754  -15.70114 -10.53575 1.000 28.71867 ? 772 HOH A O   1 
HETATM 2177 O  O   . HOH E 4 .   ? 1.28688  -9.82924  -7.42490  1.000 34.01047 ? 773 HOH A O   1 
HETATM 2178 O  O   . HOH E 4 .   ? 38.307   -20.931   -15.940   1.000 25.89381 ? 774 HOH A O   1 
HETATM 2179 O  O   . HOH E 4 .   ? 32.49647 -1.41376  -2.30110  1.000 34.09247 ? 775 HOH A O   1 
HETATM 2180 O  O   . HOH E 4 .   ? 24.64532 -42.05050 -2.95353  1.000 28.02322 ? 776 HOH A O   1 
HETATM 2181 O  O   . HOH E 4 .   ? 12.39838 -15.54809 -15.01581 1.000 40.45913 ? 777 HOH A O   1 
HETATM 2182 O  O   . HOH E 4 .   ? 1.62979  -35.31249 -11.30158 1.000 39.15582 ? 778 HOH A O   1 
HETATM 2183 O  O   . HOH E 4 .   ? 32.44294 -36.27706 0.00000   0.50  26.21951 ? 779 HOH A O   1 
HETATM 2184 O  O   . HOH E 4 .   ? 32.43825 -8.79654  -6.04962  1.000 28.13733 ? 780 HOH A O   1 
HETATM 2185 O  O   . HOH E 4 .   ? 31.37485 -27.28185 17.23897  1.000 34.38158 ? 781 HOH A O   1 
HETATM 2186 O  O   . HOH E 4 .   ? 0.94571  -5.70418  -5.26069  1.000 38.85401 ? 782 HOH A O   1 
HETATM 2187 O  O   . HOH E 4 .   ? 14.96581 -14.23606 -14.20007 1.000 38.77592 ? 783 HOH A O   1 
HETATM 2188 O  O   . HOH E 4 .   ? 11.39139 -39.04371 -1.25704  1.000 22.32055 ? 784 HOH A O   1 
HETATM 2189 O  O   . HOH E 4 .   ? 28.53703 -1.01326  -2.60829  1.000 32.68395 ? 785 HOH A O   1 
HETATM 2190 O  O   . HOH E 4 .   ? -1.63960 -33.57192 1.57936   1.000 29.68528 ? 786 HOH A O   1 
HETATM 2191 O  O   . HOH E 4 .   ? 20.66893 -39.15285 4.23914   1.000 34.90478 ? 787 HOH A O   1 
HETATM 2192 O  O   . HOH E 4 .   ? -6.28033 -18.37950 5.12779   1.000 31.32640 ? 788 HOH A O   1 
HETATM 2193 O  O   . HOH E 4 .   ? 17.26711 -13.23840 -13.85540 1.000 28.33541 ? 789 HOH A O   1 
# 
