data_9FTU
# 
_entry.id   9FTU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FTU         pdb_00009ftu 10.2210/pdb9ftu/pdb 
WWPDB D_1292139453 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FTU 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 5 
_pdbx_contact_author.email              daniele.de_sanctis@esrf.fr 
_pdbx_contact_author.name_first         Daniele 
_pdbx_contact_author.name_last          'de Sanctis' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0391-8290 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Orlans, J.'     1 0000-0002-6933-2287 
'Rose, S.L.'     2 0000-0003-4824-4066 
'Basu, S.'       3 0000-0001-6484-8236 
'de Sanctis, D.' 4 0000-0003-0391-8290 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Commun Chem' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2399-3669 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            8 
_citation.language                  ? 
_citation.page_first                6 
_citation.page_last                 6 
_citation.title                     
'Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s42004-024-01404-y 
_citation.pdbx_database_id_PubMed   39775172 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Orlans, J.'        1  ?                   
primary 'Rose, S.L.'        2  0000-0003-4824-4066 
primary 'Ferguson, G.'      3  0000-0003-2551-5994 
primary 'Oscarsson, M.'     4  ?                   
primary 'Homs Puron, A.'    5  ?                   
primary 'Beteva, A.'        6  ?                   
primary 'Debionne, S.'      7  ?                   
primary 'Theveneau, P.'     8  ?                   
primary 'Coquelle, N.'      9  ?                   
primary 'Kieffer, J.'       10 0000-0002-0730-6577 
primary 'Busca, P.'         11 ?                   
primary 'Sinoir, J.'        12 ?                   
primary 'Armijo, V.'        13 0009-0006-3243-8391 
primary 'Lopez Marrero, M.' 14 ?                   
primary 'Felisaz, F.'       15 ?                   
primary 'Papp, G.'          16 0000-0002-5702-843X 
primary 'Gonzalez, H.'      17 ?                   
primary 'Caserotto, H.'     18 ?                   
primary 'Dobias, F.'        19 ?                   
primary 'Gigmes, J.'        20 ?                   
primary 'Lebon, G.'         21 0000-0003-1162-5148 
primary 'Basu, S.'          22 0000-0001-6484-8236 
primary 'de Sanctis, D.'    23 0000-0003-0391-8290 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     nat 'Thaumatin I'        22228.043 1   ? ? ? ? 
2 non-polymer nat 'L(+)-TARTARIC ACID' 150.087   1   ? ? ? ? 
3 water       nat water                18.015    192 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        Thaumatin-1 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'L(+)-TARTARIC ACID' TLA 
3 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   THR n 
1 3   PHE n 
1 4   GLU n 
1 5   ILE n 
1 6   VAL n 
1 7   ASN n 
1 8   ARG n 
1 9   CYS n 
1 10  SER n 
1 11  TYR n 
1 12  THR n 
1 13  VAL n 
1 14  TRP n 
1 15  ALA n 
1 16  ALA n 
1 17  ALA n 
1 18  SER n 
1 19  LYS n 
1 20  GLY n 
1 21  ASP n 
1 22  ALA n 
1 23  ALA n 
1 24  LEU n 
1 25  ASP n 
1 26  ALA n 
1 27  GLY n 
1 28  GLY n 
1 29  ARG n 
1 30  GLN n 
1 31  LEU n 
1 32  ASN n 
1 33  SER n 
1 34  GLY n 
1 35  GLU n 
1 36  SER n 
1 37  TRP n 
1 38  THR n 
1 39  ILE n 
1 40  ASN n 
1 41  VAL n 
1 42  GLU n 
1 43  PRO n 
1 44  GLY n 
1 45  THR n 
1 46  ASN n 
1 47  GLY n 
1 48  GLY n 
1 49  LYS n 
1 50  ILE n 
1 51  TRP n 
1 52  ALA n 
1 53  ARG n 
1 54  THR n 
1 55  ASP n 
1 56  CYS n 
1 57  TYR n 
1 58  PHE n 
1 59  ASP n 
1 60  ASP n 
1 61  SER n 
1 62  GLY n 
1 63  SER n 
1 64  GLY n 
1 65  ILE n 
1 66  CYS n 
1 67  LYS n 
1 68  THR n 
1 69  GLY n 
1 70  ASP n 
1 71  CYS n 
1 72  GLY n 
1 73  GLY n 
1 74  LEU n 
1 75  LEU n 
1 76  ARG n 
1 77  CYS n 
1 78  LYS n 
1 79  ARG n 
1 80  PHE n 
1 81  GLY n 
1 82  ARG n 
1 83  PRO n 
1 84  PRO n 
1 85  THR n 
1 86  THR n 
1 87  LEU n 
1 88  ALA n 
1 89  GLU n 
1 90  PHE n 
1 91  SER n 
1 92  LEU n 
1 93  ASN n 
1 94  GLN n 
1 95  TYR n 
1 96  GLY n 
1 97  LYS n 
1 98  ASP n 
1 99  TYR n 
1 100 ILE n 
1 101 ASP n 
1 102 ILE n 
1 103 SER n 
1 104 ASN n 
1 105 ILE n 
1 106 LYS n 
1 107 GLY n 
1 108 PHE n 
1 109 ASN n 
1 110 VAL n 
1 111 PRO n 
1 112 MET n 
1 113 ASP n 
1 114 PHE n 
1 115 SER n 
1 116 PRO n 
1 117 THR n 
1 118 THR n 
1 119 ARG n 
1 120 GLY n 
1 121 CYS n 
1 122 ARG n 
1 123 GLY n 
1 124 VAL n 
1 125 ARG n 
1 126 CYS n 
1 127 ALA n 
1 128 ALA n 
1 129 ASP n 
1 130 ILE n 
1 131 VAL n 
1 132 GLY n 
1 133 GLN n 
1 134 CYS n 
1 135 PRO n 
1 136 ALA n 
1 137 LYS n 
1 138 LEU n 
1 139 LYS n 
1 140 ALA n 
1 141 PRO n 
1 142 GLY n 
1 143 GLY n 
1 144 GLY n 
1 145 CYS n 
1 146 ASN n 
1 147 ASP n 
1 148 ALA n 
1 149 CYS n 
1 150 THR n 
1 151 VAL n 
1 152 PHE n 
1 153 GLN n 
1 154 THR n 
1 155 SER n 
1 156 GLU n 
1 157 TYR n 
1 158 CYS n 
1 159 CYS n 
1 160 THR n 
1 161 THR n 
1 162 GLY n 
1 163 LYS n 
1 164 CYS n 
1 165 GLY n 
1 166 PRO n 
1 167 THR n 
1 168 GLU n 
1 169 TYR n 
1 170 SER n 
1 171 ARG n 
1 172 PHE n 
1 173 PHE n 
1 174 LYS n 
1 175 ARG n 
1 176 LEU n 
1 177 CYS n 
1 178 PRO n 
1 179 ASP n 
1 180 ALA n 
1 181 PHE n 
1 182 SER n 
1 183 TYR n 
1 184 VAL n 
1 185 LEU n 
1 186 ASP n 
1 187 LYS n 
1 188 PRO n 
1 189 THR n 
1 190 THR n 
1 191 VAL n 
1 192 THR n 
1 193 CYS n 
1 194 PRO n 
1 195 GLY n 
1 196 SER n 
1 197 SER n 
1 198 ASN n 
1 199 TYR n 
1 200 ARG n 
1 201 VAL n 
1 202 THR n 
1 203 PHE n 
1 204 CYS n 
1 205 PRO n 
1 206 THR n 
1 207 ALA n 
# 
_entity_src_nat.entity_id                  1 
_entity_src_nat.pdbx_src_id                1 
_entity_src_nat.pdbx_alt_source_flag       sample 
_entity_src_nat.pdbx_beg_seq_num           1 
_entity_src_nat.pdbx_end_seq_num           207 
_entity_src_nat.common_name                ? 
_entity_src_nat.pdbx_organism_scientific   'Thaumatococcus daniellii' 
_entity_src_nat.pdbx_ncbi_taxonomy_id      4621 
_entity_src_nat.genus                      ? 
_entity_src_nat.species                    ? 
_entity_src_nat.strain                     ? 
_entity_src_nat.tissue                     ? 
_entity_src_nat.tissue_fraction            ? 
_entity_src_nat.pdbx_secretion             ? 
_entity_src_nat.pdbx_fragment              ? 
_entity_src_nat.pdbx_variant               ? 
_entity_src_nat.pdbx_cell_line             ? 
_entity_src_nat.pdbx_atcc                  ? 
_entity_src_nat.pdbx_cellular_location     ? 
_entity_src_nat.pdbx_organ                 ? 
_entity_src_nat.pdbx_organelle             ? 
_entity_src_nat.pdbx_cell                  ? 
_entity_src_nat.pdbx_plasmid_name          ? 
_entity_src_nat.pdbx_plasmid_details       ? 
_entity_src_nat.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'     75.067  
HOH non-polymer         . WATER                ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'     119.119 
TLA non-polymer         . 'L(+)-TARTARIC ACID' ? 'C4 H6 O6'       150.087 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   1   ALA ALA A . n 
A 1 2   THR 2   2   2   THR THR A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   ASN 7   7   7   ASN ASN A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   CYS 9   9   9   CYS CYS A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  TYR 11  11  11  TYR TYR A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  TRP 14  14  14  TRP TRP A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  LYS 19  19  19  LYS LYS A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  ALA 23  23  23  ALA ALA A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  GLY 28  28  28  GLY GLY A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ASN 32  32  32  ASN ASN A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  TRP 37  37  37  TRP TRP A . n 
A 1 38  THR 38  38  38  THR THR A . n 
A 1 39  ILE 39  39  39  ILE ILE A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  PRO 43  43  43  PRO PRO A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  GLY 47  47  47  GLY GLY A . n 
A 1 48  GLY 48  48  48  GLY GLY A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  TRP 51  51  51  TRP TRP A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  CYS 56  56  56  CYS CYS A . n 
A 1 57  TYR 57  57  57  TYR TYR A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASP 59  59  59  ASP ASP A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLY 62  62  62  GLY GLY A . n 
A 1 63  SER 63  63  63  SER SER A . n 
A 1 64  GLY 64  64  64  GLY GLY A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  CYS 66  66  66  CYS CYS A . n 
A 1 67  LYS 67  67  67  LYS LYS A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  ASP 70  70  70  ASP ASP A . n 
A 1 71  CYS 71  71  71  CYS CYS A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  CYS 77  77  77  CYS CYS A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  ARG 82  82  82  ARG ARG A . n 
A 1 83  PRO 83  83  83  PRO PRO A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  THR 86  86  86  THR THR A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  PHE 90  90  90  PHE PHE A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  GLN 94  94  94  GLN GLN A . n 
A 1 95  TYR 95  95  95  TYR TYR A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  TYR 99  99  99  TYR TYR A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 ILE 102 102 102 ILE ILE A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 ASN 104 104 104 ASN ASN A . n 
A 1 105 ILE 105 105 105 ILE ILE A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 ASN 109 109 109 ASN ASN A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 PRO 111 111 111 PRO PRO A . n 
A 1 112 MET 112 112 112 MET MET A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 PHE 114 114 114 PHE PHE A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 PRO 116 116 116 PRO PRO A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 CYS 121 121 121 CYS CYS A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 CYS 126 126 126 CYS CYS A . n 
A 1 127 ALA 127 127 127 ALA ALA A . n 
A 1 128 ALA 128 128 128 ALA ALA A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 VAL 131 131 131 VAL VAL A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 CYS 134 134 134 CYS CYS A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 PRO 141 141 141 PRO PRO A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASP 147 147 147 ASP ASP A . n 
A 1 148 ALA 148 148 148 ALA ALA A . n 
A 1 149 CYS 149 149 149 CYS CYS A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 THR 154 154 154 THR THR A . n 
A 1 155 SER 155 155 155 SER SER A . n 
A 1 156 GLU 156 156 156 GLU GLU A . n 
A 1 157 TYR 157 157 157 TYR TYR A . n 
A 1 158 CYS 158 158 158 CYS CYS A . n 
A 1 159 CYS 159 159 159 CYS CYS A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 THR 161 161 161 THR THR A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 LYS 163 163 163 LYS LYS A . n 
A 1 164 CYS 164 164 164 CYS CYS A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 PRO 166 166 166 PRO PRO A . n 
A 1 167 THR 167 167 167 THR THR A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 PHE 173 173 173 PHE PHE A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 ARG 175 175 175 ARG ARG A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 CYS 177 177 177 CYS CYS A . n 
A 1 178 PRO 178 178 178 PRO PRO A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 TYR 183 183 183 TYR TYR A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 LYS 187 187 187 LYS LYS A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ASN 198 198 198 ASN ASN A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 ARG 200 200 200 ARG ARG A . n 
A 1 201 VAL 201 201 201 VAL VAL A . n 
A 1 202 THR 202 202 202 THR THR A . n 
A 1 203 PHE 203 203 203 PHE PHE A . n 
A 1 204 CYS 204 204 204 CYS CYS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 THR 206 206 206 THR THR A . n 
A 1 207 ALA 207 207 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 TLA 1   301 301 TLA TLA A . 
C 3 HOH 1   401 137 HOH HOH A . 
C 3 HOH 2   402 102 HOH HOH A . 
C 3 HOH 3   403 417 HOH HOH A . 
C 3 HOH 4   404 512 HOH HOH A . 
C 3 HOH 5   405 121 HOH HOH A . 
C 3 HOH 6   406 145 HOH HOH A . 
C 3 HOH 7   407 43  HOH HOH A . 
C 3 HOH 8   408 301 HOH HOH A . 
C 3 HOH 9   409 181 HOH HOH A . 
C 3 HOH 10  410 117 HOH HOH A . 
C 3 HOH 11  411 107 HOH HOH A . 
C 3 HOH 12  412 15  HOH HOH A . 
C 3 HOH 13  413 45  HOH HOH A . 
C 3 HOH 14  414 127 HOH HOH A . 
C 3 HOH 15  415 31  HOH HOH A . 
C 3 HOH 16  416 139 HOH HOH A . 
C 3 HOH 17  417 10  HOH HOH A . 
C 3 HOH 18  418 141 HOH HOH A . 
C 3 HOH 19  419 51  HOH HOH A . 
C 3 HOH 20  420 63  HOH HOH A . 
C 3 HOH 21  421 17  HOH HOH A . 
C 3 HOH 22  422 160 HOH HOH A . 
C 3 HOH 23  423 66  HOH HOH A . 
C 3 HOH 24  424 125 HOH HOH A . 
C 3 HOH 25  425 154 HOH HOH A . 
C 3 HOH 26  426 8   HOH HOH A . 
C 3 HOH 27  427 157 HOH HOH A . 
C 3 HOH 28  428 40  HOH HOH A . 
C 3 HOH 29  429 80  HOH HOH A . 
C 3 HOH 30  430 67  HOH HOH A . 
C 3 HOH 31  431 6   HOH HOH A . 
C 3 HOH 32  432 130 HOH HOH A . 
C 3 HOH 33  433 12  HOH HOH A . 
C 3 HOH 34  434 16  HOH HOH A . 
C 3 HOH 35  435 3   HOH HOH A . 
C 3 HOH 36  436 148 HOH HOH A . 
C 3 HOH 37  437 22  HOH HOH A . 
C 3 HOH 38  438 116 HOH HOH A . 
C 3 HOH 39  439 379 HOH HOH A . 
C 3 HOH 40  440 2   HOH HOH A . 
C 3 HOH 41  441 7   HOH HOH A . 
C 3 HOH 42  442 426 HOH HOH A . 
C 3 HOH 43  443 118 HOH HOH A . 
C 3 HOH 44  444 170 HOH HOH A . 
C 3 HOH 45  445 142 HOH HOH A . 
C 3 HOH 46  446 4   HOH HOH A . 
C 3 HOH 47  447 24  HOH HOH A . 
C 3 HOH 48  448 39  HOH HOH A . 
C 3 HOH 49  449 81  HOH HOH A . 
C 3 HOH 50  450 165 HOH HOH A . 
C 3 HOH 51  451 11  HOH HOH A . 
C 3 HOH 52  452 27  HOH HOH A . 
C 3 HOH 53  453 186 HOH HOH A . 
C 3 HOH 54  454 28  HOH HOH A . 
C 3 HOH 55  455 90  HOH HOH A . 
C 3 HOH 56  456 55  HOH HOH A . 
C 3 HOH 57  457 85  HOH HOH A . 
C 3 HOH 58  458 331 HOH HOH A . 
C 3 HOH 59  459 129 HOH HOH A . 
C 3 HOH 60  460 62  HOH HOH A . 
C 3 HOH 61  461 14  HOH HOH A . 
C 3 HOH 62  462 115 HOH HOH A . 
C 3 HOH 63  463 171 HOH HOH A . 
C 3 HOH 64  464 353 HOH HOH A . 
C 3 HOH 65  465 310 HOH HOH A . 
C 3 HOH 66  466 29  HOH HOH A . 
C 3 HOH 67  467 70  HOH HOH A . 
C 3 HOH 68  468 49  HOH HOH A . 
C 3 HOH 69  469 96  HOH HOH A . 
C 3 HOH 70  470 135 HOH HOH A . 
C 3 HOH 71  471 13  HOH HOH A . 
C 3 HOH 72  472 111 HOH HOH A . 
C 3 HOH 73  473 159 HOH HOH A . 
C 3 HOH 74  474 124 HOH HOH A . 
C 3 HOH 75  475 162 HOH HOH A . 
C 3 HOH 76  476 53  HOH HOH A . 
C 3 HOH 77  477 153 HOH HOH A . 
C 3 HOH 78  478 71  HOH HOH A . 
C 3 HOH 79  479 140 HOH HOH A . 
C 3 HOH 80  480 69  HOH HOH A . 
C 3 HOH 81  481 26  HOH HOH A . 
C 3 HOH 82  482 30  HOH HOH A . 
C 3 HOH 83  483 61  HOH HOH A . 
C 3 HOH 84  484 72  HOH HOH A . 
C 3 HOH 85  485 82  HOH HOH A . 
C 3 HOH 86  486 57  HOH HOH A . 
C 3 HOH 87  487 176 HOH HOH A . 
C 3 HOH 88  488 150 HOH HOH A . 
C 3 HOH 89  489 20  HOH HOH A . 
C 3 HOH 90  490 262 HOH HOH A . 
C 3 HOH 91  491 122 HOH HOH A . 
C 3 HOH 92  492 94  HOH HOH A . 
C 3 HOH 93  493 89  HOH HOH A . 
C 3 HOH 94  494 258 HOH HOH A . 
C 3 HOH 95  495 64  HOH HOH A . 
C 3 HOH 96  496 52  HOH HOH A . 
C 3 HOH 97  497 287 HOH HOH A . 
C 3 HOH 98  498 47  HOH HOH A . 
C 3 HOH 99  499 19  HOH HOH A . 
C 3 HOH 100 500 323 HOH HOH A . 
C 3 HOH 101 501 37  HOH HOH A . 
C 3 HOH 102 502 413 HOH HOH A . 
C 3 HOH 103 503 34  HOH HOH A . 
C 3 HOH 104 504 18  HOH HOH A . 
C 3 HOH 105 505 146 HOH HOH A . 
C 3 HOH 106 506 76  HOH HOH A . 
C 3 HOH 107 507 73  HOH HOH A . 
C 3 HOH 108 508 46  HOH HOH A . 
C 3 HOH 109 509 74  HOH HOH A . 
C 3 HOH 110 510 266 HOH HOH A . 
C 3 HOH 111 511 110 HOH HOH A . 
C 3 HOH 112 512 335 HOH HOH A . 
C 3 HOH 113 513 1   HOH HOH A . 
C 3 HOH 114 514 21  HOH HOH A . 
C 3 HOH 115 515 48  HOH HOH A . 
C 3 HOH 116 516 32  HOH HOH A . 
C 3 HOH 117 517 156 HOH HOH A . 
C 3 HOH 118 518 265 HOH HOH A . 
C 3 HOH 119 519 167 HOH HOH A . 
C 3 HOH 120 520 54  HOH HOH A . 
C 3 HOH 121 521 35  HOH HOH A . 
C 3 HOH 122 522 38  HOH HOH A . 
C 3 HOH 123 523 158 HOH HOH A . 
C 3 HOH 124 524 84  HOH HOH A . 
C 3 HOH 125 525 273 HOH HOH A . 
C 3 HOH 126 526 23  HOH HOH A . 
C 3 HOH 127 527 187 HOH HOH A . 
C 3 HOH 128 528 5   HOH HOH A . 
C 3 HOH 129 529 25  HOH HOH A . 
C 3 HOH 130 530 44  HOH HOH A . 
C 3 HOH 131 531 132 HOH HOH A . 
C 3 HOH 132 532 209 HOH HOH A . 
C 3 HOH 133 533 68  HOH HOH A . 
C 3 HOH 134 534 79  HOH HOH A . 
C 3 HOH 135 535 190 HOH HOH A . 
C 3 HOH 136 536 42  HOH HOH A . 
C 3 HOH 137 537 169 HOH HOH A . 
C 3 HOH 138 538 183 HOH HOH A . 
C 3 HOH 139 539 126 HOH HOH A . 
C 3 HOH 140 540 152 HOH HOH A . 
C 3 HOH 141 541 398 HOH HOH A . 
C 3 HOH 142 542 112 HOH HOH A . 
C 3 HOH 143 543 50  HOH HOH A . 
C 3 HOH 144 544 41  HOH HOH A . 
C 3 HOH 145 545 9   HOH HOH A . 
C 3 HOH 146 546 77  HOH HOH A . 
C 3 HOH 147 547 65  HOH HOH A . 
C 3 HOH 148 548 78  HOH HOH A . 
C 3 HOH 149 549 113 HOH HOH A . 
C 3 HOH 150 550 56  HOH HOH A . 
C 3 HOH 151 551 136 HOH HOH A . 
C 3 HOH 152 552 58  HOH HOH A . 
C 3 HOH 153 553 33  HOH HOH A . 
C 3 HOH 154 554 114 HOH HOH A . 
C 3 HOH 155 555 131 HOH HOH A . 
C 3 HOH 156 556 172 HOH HOH A . 
C 3 HOH 157 557 365 HOH HOH A . 
C 3 HOH 158 558 230 HOH HOH A . 
C 3 HOH 159 559 295 HOH HOH A . 
C 3 HOH 160 560 238 HOH HOH A . 
C 3 HOH 161 561 128 HOH HOH A . 
C 3 HOH 162 562 350 HOH HOH A . 
C 3 HOH 163 563 191 HOH HOH A . 
C 3 HOH 164 564 178 HOH HOH A . 
C 3 HOH 165 565 161 HOH HOH A . 
C 3 HOH 166 566 272 HOH HOH A . 
C 3 HOH 167 567 75  HOH HOH A . 
C 3 HOH 168 568 36  HOH HOH A . 
C 3 HOH 169 569 433 HOH HOH A . 
C 3 HOH 170 570 276 HOH HOH A . 
C 3 HOH 171 571 83  HOH HOH A . 
C 3 HOH 172 572 180 HOH HOH A . 
C 3 HOH 173 573 364 HOH HOH A . 
C 3 HOH 174 574 286 HOH HOH A . 
C 3 HOH 175 575 168 HOH HOH A . 
C 3 HOH 176 576 216 HOH HOH A . 
C 3 HOH 177 577 133 HOH HOH A . 
C 3 HOH 178 578 338 HOH HOH A . 
C 3 HOH 179 579 281 HOH HOH A . 
C 3 HOH 180 580 134 HOH HOH A . 
C 3 HOH 181 581 320 HOH HOH A . 
C 3 HOH 182 582 340 HOH HOH A . 
C 3 HOH 183 583 174 HOH HOH A . 
C 3 HOH 184 584 194 HOH HOH A . 
C 3 HOH 185 585 88  HOH HOH A . 
C 3 HOH 186 586 257 HOH HOH A . 
C 3 HOH 187 587 91  HOH HOH A . 
C 3 HOH 188 588 309 HOH HOH A . 
C 3 HOH 189 589 59  HOH HOH A . 
C 3 HOH 190 590 370 HOH HOH A . 
C 3 HOH 191 591 120 HOH HOH A . 
C 3 HOH 192 592 469 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASP 60  ? CG  ? A ASP 60  CG  
2  1 Y 1 A ASP 60  ? OD1 ? A ASP 60  OD1 
3  1 Y 1 A ASP 60  ? OD2 ? A ASP 60  OD2 
4  1 Y 1 A LYS 78  ? CG  ? A LYS 78  CG  
5  1 Y 1 A LYS 78  ? CD  ? A LYS 78  CD  
6  1 Y 1 A LYS 78  ? CE  ? A LYS 78  CE  
7  1 Y 1 A LYS 78  ? NZ  ? A LYS 78  NZ  
8  1 Y 1 A ARG 79  ? CG  ? A ARG 79  CG  
9  1 Y 1 A ARG 79  ? CD  ? A ARG 79  CD  
10 1 Y 1 A ARG 79  ? NE  ? A ARG 79  NE  
11 1 Y 1 A ARG 79  ? CZ  ? A ARG 79  CZ  
12 1 Y 1 A ARG 79  ? NH1 ? A ARG 79  NH1 
13 1 Y 1 A ARG 79  ? NH2 ? A ARG 79  NH2 
14 1 Y 1 A ARG 119 ? CG  ? A ARG 119 CG  
15 1 Y 1 A ARG 119 ? CD  ? A ARG 119 CD  
16 1 Y 1 A ARG 119 ? NE  ? A ARG 119 NE  
17 1 Y 1 A ARG 119 ? CZ  ? A ARG 119 CZ  
18 1 Y 1 A ARG 119 ? NH1 ? A ARG 119 NH1 
19 1 Y 1 A ARG 119 ? NH2 ? A ARG 119 NH2 
20 1 Y 1 A LYS 163 ? CG  ? A LYS 163 CG  
21 1 Y 1 A LYS 163 ? CD  ? A LYS 163 CD  
22 1 Y 1 A LYS 163 ? CE  ? A LYS 163 CE  
23 1 Y 1 A LYS 163 ? NZ  ? A LYS 163 NZ  
24 1 Y 1 A LYS 187 ? CG  ? A LYS 187 CG  
25 1 Y 1 A LYS 187 ? CD  ? A LYS 187 CD  
26 1 Y 1 A LYS 187 ? CE  ? A LYS 187 CE  
27 1 Y 1 A LYS 187 ? NZ  ? A LYS 187 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FTU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.550 
_cell.length_a_esd                 ? 
_cell.length_b                     58.550 
_cell.length_b_esd                 ? 
_cell.length_c                     151.490 
_cell.length_c_esd                 ? 
_cell.volume                       519323.248 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FTU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                92 
_symmetry.space_group_name_Hall            'P 4abw 2nw' 
_symmetry.space_group_name_H-M             'P 41 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FTU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.91 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.77 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES pH 7.5, 1.8 M Sodium Potassium Tartrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'PSI JUNGFRAU 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.072 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID29' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.072 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID29 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          21.32 
_reflns.entry_id                                       9FTU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               54.56 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     27591 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                1420 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.82 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   0.99 
_reflns.pdbx_R_split                                   0.0514 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.78 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1349 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  0.91 
_reflns_shell.pdbx_R_split                                  0.528 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.55 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FTU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             46.32 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27504 
_refine.ls_number_reflns_R_free                  1999 
_refine.ls_number_reflns_R_work                  25505 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 7.27 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1403 
_refine.ls_R_factor_R_free                       0.1662 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1383 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 14.3238 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1674 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        46.32 
_refine_hist.number_atoms_solvent             192 
_refine_hist.number_atoms_total               1720 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1518 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0134  ? 1591 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2338  ? 2172 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0886  ? 238  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0116  ? 289  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.0097 ? 563  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.79  . . 140 1781 100.00 . . . . 0.2469 . . . . . . . . . . . 0.2813 
'X-RAY DIFFRACTION' 1.79 1.84  . . 140 1790 100.00 . . . . 0.1892 . . . . . . . . . . . 0.2220 
'X-RAY DIFFRACTION' 1.84 1.90  . . 139 1784 100.00 . . . . 0.1613 . . . . . . . . . . . 0.2040 
'X-RAY DIFFRACTION' 1.90 1.96  . . 140 1778 100.00 . . . . 0.1520 . . . . . . . . . . . 0.1854 
'X-RAY DIFFRACTION' 1.96 2.03  . . 140 1786 100.00 . . . . 0.1611 . . . . . . . . . . . 0.1981 
'X-RAY DIFFRACTION' 2.03 2.11  . . 141 1802 100.00 . . . . 0.1424 . . . . . . . . . . . 0.1865 
'X-RAY DIFFRACTION' 2.11 2.20  . . 140 1780 100.00 . . . . 0.1403 . . . . . . . . . . . 0.2076 
'X-RAY DIFFRACTION' 2.20 2.32  . . 143 1813 100.00 . . . . 0.1395 . . . . . . . . . . . 0.1737 
'X-RAY DIFFRACTION' 2.32 2.47  . . 141 1816 100.00 . . . . 0.1385 . . . . . . . . . . . 0.1496 
'X-RAY DIFFRACTION' 2.47 2.66  . . 143 1815 100.00 . . . . 0.1531 . . . . . . . . . . . 0.1662 
'X-RAY DIFFRACTION' 2.66 2.92  . . 143 1827 100.00 . . . . 0.1550 . . . . . . . . . . . 0.1612 
'X-RAY DIFFRACTION' 2.92 3.35  . . 144 1840 100.00 . . . . 0.1422 . . . . . . . . . . . 0.1819 
'X-RAY DIFFRACTION' 3.35 4.22  . . 148 1890 99.90  . . . . 0.1147 . . . . . . . . . . . 0.1380 
'X-RAY DIFFRACTION' 4.22 46.32 . . 157 2003 99.91  . . . . 0.1124 . . . . . . . . . . . 0.1350 
# 
_struct.entry_id                     9FTU 
_struct.title                        'Serial microseconds crystallography at ID29 using ASU extruder: Thaumatin' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FTU 
_struct_keywords.text            
'Serial Crystallography, serial microsecond crystallography, room temperature, ID29, ESRF-EBS, PLANT PROTEIN' 
_struct_keywords.pdbx_keywords   'PLANT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    THM1_THADA 
_struct_ref.pdbx_db_accession          P02883 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_struct_ref.pdbx_align_begin           23 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FTU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 207 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P02883 
_struct_ref_seq.db_align_beg                  23 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  229 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       207 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASP A 129 ? CYS A 134 ? ASP A 129 CYS A 134 1 ? 6  
HELX_P HELX_P2 AA2 PRO A 135 ? LYS A 139 ? PRO A 135 LYS A 139 5 ? 5  
HELX_P HELX_P3 AA3 ASP A 147 ? GLN A 153 ? ASP A 147 GLN A 153 1 ? 7  
HELX_P HELX_P4 AA4 THR A 154 ? CYS A 159 ? THR A 154 CYS A 159 1 ? 6  
HELX_P HELX_P5 AA5 THR A 167 ? CYS A 177 ? THR A 167 CYS A 177 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 9   SG ? ? ? 1_555 A CYS 204 SG ? ? A CYS 9   A CYS 204 1_555 ? ? ? ? ? ? ? 1.999 ? ? 
disulf2 disulf ? ? A CYS 56  SG ? ? ? 1_555 A CYS 66  SG ? ? A CYS 56  A CYS 66  1_555 ? ? ? ? ? ? ? 2.025 ? ? 
disulf3 disulf ? ? A CYS 71  SG ? ? ? 1_555 A CYS 77  SG ? ? A CYS 71  A CYS 77  1_555 ? ? ? ? ? ? ? 2.024 ? ? 
disulf4 disulf ? ? A CYS 121 SG ? ? ? 1_555 A CYS 193 SG ? ? A CYS 121 A CYS 193 1_555 ? ? ? ? ? ? ? 2.028 ? ? 
disulf5 disulf ? ? A CYS 126 SG ? ? ? 1_555 A CYS 177 SG ? ? A CYS 126 A CYS 177 1_555 ? ? ? ? ? ? ? 2.018 ? ? 
disulf6 disulf ? ? A CYS 134 SG ? ? ? 1_555 A CYS 145 SG ? ? A CYS 134 A CYS 145 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf7 disulf ? ? A CYS 149 SG ? ? ? 1_555 A CYS 158 SG ? ? A CYS 149 A CYS 158 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
disulf8 disulf ? ? A CYS 159 SG A ? ? 1_555 A CYS 164 SG ? ? A CYS 159 A CYS 164 1_555 ? ? ? ? ? ? ? 2.023 ? ? 
disulf9 disulf ? ? A CYS 159 SG B ? ? 1_555 A CYS 164 SG ? ? A CYS 159 A CYS 164 1_555 ? ? ? ? ? ? ? 1.997 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 9   ? CYS A 204 ? CYS A 9   ? 1_555 CYS A 204 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 56  ? CYS A 66  ? CYS A 56  ? 1_555 CYS A 66  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 71  ? CYS A 77  ? CYS A 71  ? 1_555 CYS A 77  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 121 ? CYS A 193 ? CYS A 121 ? 1_555 CYS A 193 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 126 ? CYS A 177 ? CYS A 126 ? 1_555 CYS A 177 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS A 134 ? CYS A 145 ? CYS A 134 ? 1_555 CYS A 145 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS A 149 ? CYS A 158 ? CYS A 149 ? 1_555 CYS A 158 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS A 159 A CYS A 164 ? CYS A 159 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
9 CYS A 159 B CYS A 164 ? CYS A 159 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PRO 
_struct_mon_prot_cis.label_seq_id           83 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PRO 
_struct_mon_prot_cis.auth_seq_id            83 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    84 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     84 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       5.36 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 6 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 36  ? ASN A 40  ? SER A 36  ASN A 40  
AA1 2 THR A 2   ? ASN A 7   ? THR A 2   ASN A 7   
AA1 3 TYR A 199 ? PHE A 203 ? TYR A 199 PHE A 203 
AA1 4 MET A 112 ? PRO A 116 ? MET A 112 PRO A 116 
AA1 5 VAL A 124 ? CYS A 126 ? VAL A 124 CYS A 126 
AA2 1 ALA A 23  ? LEU A 31  ? ALA A 23  LEU A 31  
AA2 2 VAL A 13  ? SER A 18  ? VAL A 13  SER A 18  
AA2 3 GLY A 48  ? ARG A 53  ? GLY A 48  ARG A 53  
AA2 4 LEU A 87  ? GLN A 94  ? LEU A 87  GLN A 94  
AA2 5 LYS A 97  ? SER A 103 ? LYS A 97  SER A 103 
AA2 6 VAL A 191 ? PRO A 194 ? VAL A 191 PRO A 194 
AA3 1 TYR A 57  ? PHE A 58  ? TYR A 57  PHE A 58  
AA3 2 GLY A 64  ? ILE A 65  ? GLY A 64  ILE A 65  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TRP A 37  ? O TRP A 37  N ILE A 5   ? N ILE A 5   
AA1 2 3 N VAL A 6   ? N VAL A 6   O VAL A 201 ? O VAL A 201 
AA1 3 4 O ARG A 200 ? O ARG A 200 N SER A 115 ? N SER A 115 
AA1 4 5 N PHE A 114 ? N PHE A 114 O VAL A 124 ? O VAL A 124 
AA2 1 2 O LEU A 31  ? O LEU A 31  N VAL A 13  ? N VAL A 13  
AA2 2 3 N SER A 18  ? N SER A 18  O LYS A 49  ? O LYS A 49  
AA2 3 4 N ILE A 50  ? N ILE A 50  O ALA A 88  ? O ALA A 88  
AA2 4 5 N GLN A 94  ? N GLN A 94  O LYS A 97  ? O LYS A 97  
AA2 5 6 N ASP A 98  ? N ASP A 98  O CYS A 193 ? O CYS A 193 
AA3 1 2 N TYR A 57  ? N TYR A 57  O ILE A 65  ? O ILE A 65  
# 
_pdbx_entry_details.entry_id                   9FTU 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O A HOH 588 ? ? O A HOH 590 ? ? 1.49 
2  1 O A HOH 542 ? ? O A HOH 549 ? ? 1.70 
3  1 O A HOH 443 ? ? O A HOH 473 ? ? 1.76 
4  1 O A HOH 538 ? ? O A HOH 563 ? ? 1.86 
5  1 O A HOH 502 ? ? O A HOH 541 ? ? 1.90 
6  1 O A HOH 403 ? ? O A HOH 543 ? ? 2.03 
7  1 O A HOH 472 ? ? O A HOH 485 ? ? 2.07 
8  1 O A HOH 494 ? ? O A HOH 562 ? ? 2.13 
9  1 O A HOH 462 ? ? O A HOH 535 ? ? 2.16 
10 1 O A HOH 531 ? ? O A HOH 579 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     566 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     570 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_554 
_pdbx_validate_symm_contact.dist              1.52 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 25 ? ? 52.72   -137.73 
2 1 CYS A 71 ? ? -113.38 69.92   
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     ALA 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      207 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    ALA 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     207 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HOH O    O N N 137 
HOH H1   H N N 138 
HOH H2   H N N 139 
ILE N    N N N 140 
ILE CA   C N S 141 
ILE C    C N N 142 
ILE O    O N N 143 
ILE CB   C N S 144 
ILE CG1  C N N 145 
ILE CG2  C N N 146 
ILE CD1  C N N 147 
ILE OXT  O N N 148 
ILE H    H N N 149 
ILE H2   H N N 150 
ILE HA   H N N 151 
ILE HB   H N N 152 
ILE HG12 H N N 153 
ILE HG13 H N N 154 
ILE HG21 H N N 155 
ILE HG22 H N N 156 
ILE HG23 H N N 157 
ILE HD11 H N N 158 
ILE HD12 H N N 159 
ILE HD13 H N N 160 
ILE HXT  H N N 161 
LEU N    N N N 162 
LEU CA   C N S 163 
LEU C    C N N 164 
LEU O    O N N 165 
LEU CB   C N N 166 
LEU CG   C N N 167 
LEU CD1  C N N 168 
LEU CD2  C N N 169 
LEU OXT  O N N 170 
LEU H    H N N 171 
LEU H2   H N N 172 
LEU HA   H N N 173 
LEU HB2  H N N 174 
LEU HB3  H N N 175 
LEU HG   H N N 176 
LEU HD11 H N N 177 
LEU HD12 H N N 178 
LEU HD13 H N N 179 
LEU HD21 H N N 180 
LEU HD22 H N N 181 
LEU HD23 H N N 182 
LEU HXT  H N N 183 
LYS N    N N N 184 
LYS CA   C N S 185 
LYS C    C N N 186 
LYS O    O N N 187 
LYS CB   C N N 188 
LYS CG   C N N 189 
LYS CD   C N N 190 
LYS CE   C N N 191 
LYS NZ   N N N 192 
LYS OXT  O N N 193 
LYS H    H N N 194 
LYS H2   H N N 195 
LYS HA   H N N 196 
LYS HB2  H N N 197 
LYS HB3  H N N 198 
LYS HG2  H N N 199 
LYS HG3  H N N 200 
LYS HD2  H N N 201 
LYS HD3  H N N 202 
LYS HE2  H N N 203 
LYS HE3  H N N 204 
LYS HZ1  H N N 205 
LYS HZ2  H N N 206 
LYS HZ3  H N N 207 
LYS HXT  H N N 208 
MET N    N N N 209 
MET CA   C N S 210 
MET C    C N N 211 
MET O    O N N 212 
MET CB   C N N 213 
MET CG   C N N 214 
MET SD   S N N 215 
MET CE   C N N 216 
MET OXT  O N N 217 
MET H    H N N 218 
MET H2   H N N 219 
MET HA   H N N 220 
MET HB2  H N N 221 
MET HB3  H N N 222 
MET HG2  H N N 223 
MET HG3  H N N 224 
MET HE1  H N N 225 
MET HE2  H N N 226 
MET HE3  H N N 227 
MET HXT  H N N 228 
PHE N    N N N 229 
PHE CA   C N S 230 
PHE C    C N N 231 
PHE O    O N N 232 
PHE CB   C N N 233 
PHE CG   C Y N 234 
PHE CD1  C Y N 235 
PHE CD2  C Y N 236 
PHE CE1  C Y N 237 
PHE CE2  C Y N 238 
PHE CZ   C Y N 239 
PHE OXT  O N N 240 
PHE H    H N N 241 
PHE H2   H N N 242 
PHE HA   H N N 243 
PHE HB2  H N N 244 
PHE HB3  H N N 245 
PHE HD1  H N N 246 
PHE HD2  H N N 247 
PHE HE1  H N N 248 
PHE HE2  H N N 249 
PHE HZ   H N N 250 
PHE HXT  H N N 251 
PRO N    N N N 252 
PRO CA   C N S 253 
PRO C    C N N 254 
PRO O    O N N 255 
PRO CB   C N N 256 
PRO CG   C N N 257 
PRO CD   C N N 258 
PRO OXT  O N N 259 
PRO H    H N N 260 
PRO HA   H N N 261 
PRO HB2  H N N 262 
PRO HB3  H N N 263 
PRO HG2  H N N 264 
PRO HG3  H N N 265 
PRO HD2  H N N 266 
PRO HD3  H N N 267 
PRO HXT  H N N 268 
SER N    N N N 269 
SER CA   C N S 270 
SER C    C N N 271 
SER O    O N N 272 
SER CB   C N N 273 
SER OG   O N N 274 
SER OXT  O N N 275 
SER H    H N N 276 
SER H2   H N N 277 
SER HA   H N N 278 
SER HB2  H N N 279 
SER HB3  H N N 280 
SER HG   H N N 281 
SER HXT  H N N 282 
THR N    N N N 283 
THR CA   C N S 284 
THR C    C N N 285 
THR O    O N N 286 
THR CB   C N R 287 
THR OG1  O N N 288 
THR CG2  C N N 289 
THR OXT  O N N 290 
THR H    H N N 291 
THR H2   H N N 292 
THR HA   H N N 293 
THR HB   H N N 294 
THR HG1  H N N 295 
THR HG21 H N N 296 
THR HG22 H N N 297 
THR HG23 H N N 298 
THR HXT  H N N 299 
TLA O1   O N N 300 
TLA O11  O N N 301 
TLA C1   C N N 302 
TLA C2   C N R 303 
TLA O2   O N N 304 
TLA C3   C N R 305 
TLA O3   O N N 306 
TLA C4   C N N 307 
TLA O4   O N N 308 
TLA O41  O N N 309 
TLA H11  H N N 310 
TLA H2   H N N 311 
TLA HA   H N N 312 
TLA H3   H N N 313 
TLA HB   H N N 314 
TLA H41  H N N 315 
TRP N    N N N 316 
TRP CA   C N S 317 
TRP C    C N N 318 
TRP O    O N N 319 
TRP CB   C N N 320 
TRP CG   C Y N 321 
TRP CD1  C Y N 322 
TRP CD2  C Y N 323 
TRP NE1  N Y N 324 
TRP CE2  C Y N 325 
TRP CE3  C Y N 326 
TRP CZ2  C Y N 327 
TRP CZ3  C Y N 328 
TRP CH2  C Y N 329 
TRP OXT  O N N 330 
TRP H    H N N 331 
TRP H2   H N N 332 
TRP HA   H N N 333 
TRP HB2  H N N 334 
TRP HB3  H N N 335 
TRP HD1  H N N 336 
TRP HE1  H N N 337 
TRP HE3  H N N 338 
TRP HZ2  H N N 339 
TRP HZ3  H N N 340 
TRP HH2  H N N 341 
TRP HXT  H N N 342 
TYR N    N N N 343 
TYR CA   C N S 344 
TYR C    C N N 345 
TYR O    O N N 346 
TYR CB   C N N 347 
TYR CG   C Y N 348 
TYR CD1  C Y N 349 
TYR CD2  C Y N 350 
TYR CE1  C Y N 351 
TYR CE2  C Y N 352 
TYR CZ   C Y N 353 
TYR OH   O N N 354 
TYR OXT  O N N 355 
TYR H    H N N 356 
TYR H2   H N N 357 
TYR HA   H N N 358 
TYR HB2  H N N 359 
TYR HB3  H N N 360 
TYR HD1  H N N 361 
TYR HD2  H N N 362 
TYR HE1  H N N 363 
TYR HE2  H N N 364 
TYR HH   H N N 365 
TYR HXT  H N N 366 
VAL N    N N N 367 
VAL CA   C N S 368 
VAL C    C N N 369 
VAL O    O N N 370 
VAL CB   C N N 371 
VAL CG1  C N N 372 
VAL CG2  C N N 373 
VAL OXT  O N N 374 
VAL H    H N N 375 
VAL H2   H N N 376 
VAL HA   H N N 377 
VAL HB   H N N 378 
VAL HG11 H N N 379 
VAL HG12 H N N 380 
VAL HG13 H N N 381 
VAL HG21 H N N 382 
VAL HG22 H N N 383 
VAL HG23 H N N 384 
VAL HXT  H N N 385 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HOH O   H1   sing N N 129 
HOH O   H2   sing N N 130 
ILE N   CA   sing N N 131 
ILE N   H    sing N N 132 
ILE N   H2   sing N N 133 
ILE CA  C    sing N N 134 
ILE CA  CB   sing N N 135 
ILE CA  HA   sing N N 136 
ILE C   O    doub N N 137 
ILE C   OXT  sing N N 138 
ILE CB  CG1  sing N N 139 
ILE CB  CG2  sing N N 140 
ILE CB  HB   sing N N 141 
ILE CG1 CD1  sing N N 142 
ILE CG1 HG12 sing N N 143 
ILE CG1 HG13 sing N N 144 
ILE CG2 HG21 sing N N 145 
ILE CG2 HG22 sing N N 146 
ILE CG2 HG23 sing N N 147 
ILE CD1 HD11 sing N N 148 
ILE CD1 HD12 sing N N 149 
ILE CD1 HD13 sing N N 150 
ILE OXT HXT  sing N N 151 
LEU N   CA   sing N N 152 
LEU N   H    sing N N 153 
LEU N   H2   sing N N 154 
LEU CA  C    sing N N 155 
LEU CA  CB   sing N N 156 
LEU CA  HA   sing N N 157 
LEU C   O    doub N N 158 
LEU C   OXT  sing N N 159 
LEU CB  CG   sing N N 160 
LEU CB  HB2  sing N N 161 
LEU CB  HB3  sing N N 162 
LEU CG  CD1  sing N N 163 
LEU CG  CD2  sing N N 164 
LEU CG  HG   sing N N 165 
LEU CD1 HD11 sing N N 166 
LEU CD1 HD12 sing N N 167 
LEU CD1 HD13 sing N N 168 
LEU CD2 HD21 sing N N 169 
LEU CD2 HD22 sing N N 170 
LEU CD2 HD23 sing N N 171 
LEU OXT HXT  sing N N 172 
LYS N   CA   sing N N 173 
LYS N   H    sing N N 174 
LYS N   H2   sing N N 175 
LYS CA  C    sing N N 176 
LYS CA  CB   sing N N 177 
LYS CA  HA   sing N N 178 
LYS C   O    doub N N 179 
LYS C   OXT  sing N N 180 
LYS CB  CG   sing N N 181 
LYS CB  HB2  sing N N 182 
LYS CB  HB3  sing N N 183 
LYS CG  CD   sing N N 184 
LYS CG  HG2  sing N N 185 
LYS CG  HG3  sing N N 186 
LYS CD  CE   sing N N 187 
LYS CD  HD2  sing N N 188 
LYS CD  HD3  sing N N 189 
LYS CE  NZ   sing N N 190 
LYS CE  HE2  sing N N 191 
LYS CE  HE3  sing N N 192 
LYS NZ  HZ1  sing N N 193 
LYS NZ  HZ2  sing N N 194 
LYS NZ  HZ3  sing N N 195 
LYS OXT HXT  sing N N 196 
MET N   CA   sing N N 197 
MET N   H    sing N N 198 
MET N   H2   sing N N 199 
MET CA  C    sing N N 200 
MET CA  CB   sing N N 201 
MET CA  HA   sing N N 202 
MET C   O    doub N N 203 
MET C   OXT  sing N N 204 
MET CB  CG   sing N N 205 
MET CB  HB2  sing N N 206 
MET CB  HB3  sing N N 207 
MET CG  SD   sing N N 208 
MET CG  HG2  sing N N 209 
MET CG  HG3  sing N N 210 
MET SD  CE   sing N N 211 
MET CE  HE1  sing N N 212 
MET CE  HE2  sing N N 213 
MET CE  HE3  sing N N 214 
MET OXT HXT  sing N N 215 
PHE N   CA   sing N N 216 
PHE N   H    sing N N 217 
PHE N   H2   sing N N 218 
PHE CA  C    sing N N 219 
PHE CA  CB   sing N N 220 
PHE CA  HA   sing N N 221 
PHE C   O    doub N N 222 
PHE C   OXT  sing N N 223 
PHE CB  CG   sing N N 224 
PHE CB  HB2  sing N N 225 
PHE CB  HB3  sing N N 226 
PHE CG  CD1  doub Y N 227 
PHE CG  CD2  sing Y N 228 
PHE CD1 CE1  sing Y N 229 
PHE CD1 HD1  sing N N 230 
PHE CD2 CE2  doub Y N 231 
PHE CD2 HD2  sing N N 232 
PHE CE1 CZ   doub Y N 233 
PHE CE1 HE1  sing N N 234 
PHE CE2 CZ   sing Y N 235 
PHE CE2 HE2  sing N N 236 
PHE CZ  HZ   sing N N 237 
PHE OXT HXT  sing N N 238 
PRO N   CA   sing N N 239 
PRO N   CD   sing N N 240 
PRO N   H    sing N N 241 
PRO CA  C    sing N N 242 
PRO CA  CB   sing N N 243 
PRO CA  HA   sing N N 244 
PRO C   O    doub N N 245 
PRO C   OXT  sing N N 246 
PRO CB  CG   sing N N 247 
PRO CB  HB2  sing N N 248 
PRO CB  HB3  sing N N 249 
PRO CG  CD   sing N N 250 
PRO CG  HG2  sing N N 251 
PRO CG  HG3  sing N N 252 
PRO CD  HD2  sing N N 253 
PRO CD  HD3  sing N N 254 
PRO OXT HXT  sing N N 255 
SER N   CA   sing N N 256 
SER N   H    sing N N 257 
SER N   H2   sing N N 258 
SER CA  C    sing N N 259 
SER CA  CB   sing N N 260 
SER CA  HA   sing N N 261 
SER C   O    doub N N 262 
SER C   OXT  sing N N 263 
SER CB  OG   sing N N 264 
SER CB  HB2  sing N N 265 
SER CB  HB3  sing N N 266 
SER OG  HG   sing N N 267 
SER OXT HXT  sing N N 268 
THR N   CA   sing N N 269 
THR N   H    sing N N 270 
THR N   H2   sing N N 271 
THR CA  C    sing N N 272 
THR CA  CB   sing N N 273 
THR CA  HA   sing N N 274 
THR C   O    doub N N 275 
THR C   OXT  sing N N 276 
THR CB  OG1  sing N N 277 
THR CB  CG2  sing N N 278 
THR CB  HB   sing N N 279 
THR OG1 HG1  sing N N 280 
THR CG2 HG21 sing N N 281 
THR CG2 HG22 sing N N 282 
THR CG2 HG23 sing N N 283 
THR OXT HXT  sing N N 284 
TLA O1  C1   doub N N 285 
TLA O11 C1   sing N N 286 
TLA O11 H11  sing N N 287 
TLA C1  C2   sing N N 288 
TLA C2  O2   sing N N 289 
TLA C2  C3   sing N N 290 
TLA C2  H2   sing N N 291 
TLA O2  HA   sing N N 292 
TLA C3  O3   sing N N 293 
TLA C3  C4   sing N N 294 
TLA C3  H3   sing N N 295 
TLA O3  HB   sing N N 296 
TLA C4  O4   doub N N 297 
TLA C4  O41  sing N N 298 
TLA O41 H41  sing N N 299 
TRP N   CA   sing N N 300 
TRP N   H    sing N N 301 
TRP N   H2   sing N N 302 
TRP CA  C    sing N N 303 
TRP CA  CB   sing N N 304 
TRP CA  HA   sing N N 305 
TRP C   O    doub N N 306 
TRP C   OXT  sing N N 307 
TRP CB  CG   sing N N 308 
TRP CB  HB2  sing N N 309 
TRP CB  HB3  sing N N 310 
TRP CG  CD1  doub Y N 311 
TRP CG  CD2  sing Y N 312 
TRP CD1 NE1  sing Y N 313 
TRP CD1 HD1  sing N N 314 
TRP CD2 CE2  doub Y N 315 
TRP CD2 CE3  sing Y N 316 
TRP NE1 CE2  sing Y N 317 
TRP NE1 HE1  sing N N 318 
TRP CE2 CZ2  sing Y N 319 
TRP CE3 CZ3  doub Y N 320 
TRP CE3 HE3  sing N N 321 
TRP CZ2 CH2  doub Y N 322 
TRP CZ2 HZ2  sing N N 323 
TRP CZ3 CH2  sing Y N 324 
TRP CZ3 HZ3  sing N N 325 
TRP CH2 HH2  sing N N 326 
TRP OXT HXT  sing N N 327 
TYR N   CA   sing N N 328 
TYR N   H    sing N N 329 
TYR N   H2   sing N N 330 
TYR CA  C    sing N N 331 
TYR CA  CB   sing N N 332 
TYR CA  HA   sing N N 333 
TYR C   O    doub N N 334 
TYR C   OXT  sing N N 335 
TYR CB  CG   sing N N 336 
TYR CB  HB2  sing N N 337 
TYR CB  HB3  sing N N 338 
TYR CG  CD1  doub Y N 339 
TYR CG  CD2  sing Y N 340 
TYR CD1 CE1  sing Y N 341 
TYR CD1 HD1  sing N N 342 
TYR CD2 CE2  doub Y N 343 
TYR CD2 HD2  sing N N 344 
TYR CE1 CZ   doub Y N 345 
TYR CE1 HE1  sing N N 346 
TYR CE2 CZ   sing Y N 347 
TYR CE2 HE2  sing N N 348 
TYR CZ  OH   sing N N 349 
TYR OH  HH   sing N N 350 
TYR OXT HXT  sing N N 351 
VAL N   CA   sing N N 352 
VAL N   H    sing N N 353 
VAL N   H2   sing N N 354 
VAL CA  C    sing N N 355 
VAL CA  CB   sing N N 356 
VAL CA  HA   sing N N 357 
VAL C   O    doub N N 358 
VAL C   OXT  sing N N 359 
VAL CB  CG1  sing N N 360 
VAL CB  CG2  sing N N 361 
VAL CB  HB   sing N N 362 
VAL CG1 HG11 sing N N 363 
VAL CG1 HG12 sing N N 364 
VAL CG1 HG13 sing N N 365 
VAL CG2 HG21 sing N N 366 
VAL CG2 HG22 sing N N 367 
VAL CG2 HG23 sing N N 368 
VAL OXT HXT  sing N N 369 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WR8 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   'ASU extruder' 
_pdbx_serial_crystallography_sample_delivery.method        injection 
# 
_atom_sites.entry_id                    9FTU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017079 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017079 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006601 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? -21.86953 10.92148 -9.93913  1.000 28.59967 ? 1   ALA A N   1 
ATOM   2    C CA  . ALA A 1 1   ? -21.50372 12.34129 -10.05890 1.000 30.17409 ? 1   ALA A CA  1 
ATOM   3    C C   . ALA A 1 1   ? -20.50725 12.39998 -11.19544 1.000 22.72662 ? 1   ALA A C   1 
ATOM   4    O O   . ALA A 1 1   ? -19.74923 11.43823 -11.39196 1.000 23.96804 ? 1   ALA A O   1 
ATOM   5    C CB  . ALA A 1 1   ? -20.88002 12.87793 -8.78270  1.000 26.62196 ? 1   ALA A CB  1 
ATOM   6    N N   . THR A 1 2   ? -20.50127 13.49473 -11.95204 1.000 20.43725 ? 2   THR A N   1 
ATOM   7    C CA  A THR A 1 2   ? -19.58359 13.72565 -13.06577 0.602 17.61140 ? 2   THR A CA  1 
ATOM   8    C CA  B THR A 1 2   ? -19.50741 13.63503 -13.00728 0.398 17.40857 ? 2   THR A CA  1 
ATOM   9    C C   . THR A 1 2   ? -18.47219 14.67246 -12.59579 1.000 16.58568 ? 2   THR A C   1 
ATOM   10   O O   . THR A 1 2   ? -18.78586 15.69202 -11.99879 1.000 20.15306 ? 2   THR A O   1 
ATOM   11   C CB  A THR A 1 2   ? -20.35925 14.38133 -14.21298 0.602 20.79893 ? 2   THR A CB  1 
ATOM   12   C CB  B THR A 1 2   ? -20.10690 14.04499 -14.34586 0.398 22.50292 ? 2   THR A CB  1 
ATOM   13   O OG1 A THR A 1 2   ? -21.52868 13.59643 -14.51274 0.602 23.43681 ? 2   THR A OG1 1 
ATOM   14   O OG1 B THR A 1 2   ? -20.74735 15.31178 -14.19059 0.398 20.64575 ? 2   THR A OG1 1 
ATOM   15   C CG2 A THR A 1 2   ? -19.52172 14.52845 -15.44638 0.602 20.44166 ? 2   THR A CG2 1 
ATOM   16   C CG2 B THR A 1 2   ? -21.09378 12.97762 -14.83914 0.398 19.36658 ? 2   THR A CG2 1 
ATOM   17   N N   . PHE A 1 3   ? -17.22128 14.33950 -12.87540 1.000 20.53239 ? 3   PHE A N   1 
ATOM   18   C CA  . PHE A 1 3   ? -16.08944 15.24099 -12.67763 1.000 15.92351 ? 3   PHE A CA  1 
ATOM   19   C C   . PHE A 1 3   ? -15.49006 15.47686 -14.05674 1.000 16.31828 ? 3   PHE A C   1 
ATOM   20   O O   . PHE A 1 3   ? -15.17058 14.51671 -14.74691 1.000 23.75320 ? 3   PHE A O   1 
ATOM   21   C CB  . PHE A 1 3   ? -15.03651 14.61375 -11.79179 1.000 17.46677 ? 3   PHE A CB  1 
ATOM   22   C CG  . PHE A 1 3   ? -15.38780 14.62643 -10.31923 1.000 21.34449 ? 3   PHE A CG  1 
ATOM   23   C CD1 . PHE A 1 3   ? -16.38570 13.76569 -9.82764  1.000 21.95907 ? 3   PHE A CD1 1 
ATOM   24   C CD2 . PHE A 1 3   ? -14.71644 15.45248 -9.43135  1.000 21.14241 ? 3   PHE A CD2 1 
ATOM   25   C CE1 . PHE A 1 3   ? -16.70124 13.72201 -8.48362  1.000 23.86719 ? 3   PHE A CE1 1 
ATOM   26   C CE2 . PHE A 1 3   ? -15.02986 15.41587 -8.08377  1.000 22.20224 ? 3   PHE A CE2 1 
ATOM   27   C CZ  . PHE A 1 3   ? -16.03104 14.54968 -7.61334  1.000 18.92052 ? 3   PHE A CZ  1 
ATOM   28   N N   . GLU A 1 4   ? -15.32034 16.72477 -14.45020 1.000 14.37238 ? 4   GLU A N   1 
ATOM   29   C CA  . GLU A 1 4   ? -14.56740 17.00555 -15.66603 1.000 17.00958 ? 4   GLU A CA  1 
ATOM   30   C C   . GLU A 1 4   ? -13.18701 17.45671 -15.21649 1.000 18.53503 ? 4   GLU A C   1 
ATOM   31   O O   . GLU A 1 4   ? -13.08552 18.37686 -14.40580 1.000 18.63390 ? 4   GLU A O   1 
ATOM   32   C CB  . GLU A 1 4   ? -15.21147 18.09309 -16.51662 1.000 21.51339 ? 4   GLU A CB  1 
ATOM   33   C CG  . GLU A 1 4   ? -14.44834 18.27284 -17.83222 1.000 20.93867 ? 4   GLU A CG  1 
ATOM   34   C CD  . GLU A 1 4   ? -15.06715 19.33813 -18.77248 1.000 22.07127 ? 4   GLU A CD  1 
ATOM   35   O OE1 . GLU A 1 4   ? -15.27165 20.47409 -18.35240 1.000 25.30656 ? 4   GLU A OE1 1 
ATOM   36   O OE2 . GLU A 1 4   ? -15.36773 18.96530 -19.92017 1.000 28.08937 ? 4   GLU A OE2 1 
ATOM   37   N N   . ILE A 1 5   ? -12.14535 16.79300 -15.70870 1.000 15.77042 ? 5   ILE A N   1 
ATOM   38   C CA  . ILE A 1 5   ? -10.77080 17.10084 -15.30624 1.000 14.80827 ? 5   ILE A CA  1 
ATOM   39   C C   . ILE A 1 5   ? -10.09846 17.73227 -16.51796 1.000 14.13555 ? 5   ILE A C   1 
ATOM   40   O O   . ILE A 1 5   ? -10.01840 17.12179 -17.58913 1.000 16.73019 ? 5   ILE A O   1 
ATOM   41   C CB  . ILE A 1 5   ? -10.04143 15.84727 -14.83172 1.000 15.52890 ? 5   ILE A CB  1 
ATOM   42   C CG1 . ILE A 1 5   ? -10.83838 15.21406 -13.67466 1.000 19.03062 ? 5   ILE A CG1 1 
ATOM   43   C CG2 . ILE A 1 5   ? -8.59006  16.16868 -14.43870 1.000 16.55184 ? 5   ILE A CG2 1 
ATOM   44   C CD1 . ILE A 1 5   ? -10.40002 13.77171 -13.34403 1.000 23.68958 ? 5   ILE A CD1 1 
ATOM   45   N N   . VAL A 1 6   ? -9.62789  18.96814 -16.34326 1.000 13.45923 ? 6   VAL A N   1 
ATOM   46   C CA  . VAL A 1 6   ? -9.15030  19.79235 -17.45362 1.000 17.04659 ? 6   VAL A CA  1 
ATOM   47   C C   . VAL A 1 6   ? -7.69772  20.14342 -17.20203 1.000 15.44301 ? 6   VAL A C   1 
ATOM   48   O O   . VAL A 1 6   ? -7.38721  20.67194 -16.13375 1.000 15.89615 ? 6   VAL A O   1 
ATOM   49   C CB  . VAL A 1 6   ? -9.95347  21.09045 -17.56294 1.000 17.98455 ? 6   VAL A CB  1 
ATOM   50   C CG1 . VAL A 1 6   ? -9.37940  21.96691 -18.77736 1.000 17.00273 ? 6   VAL A CG1 1 
ATOM   51   C CG2 . VAL A 1 6   ? -11.44428 20.73669 -17.71534 1.000 17.00996 ? 6   VAL A CG2 1 
ATOM   52   N N   . ASN A 1 7   ? -6.82476  19.91242 -18.19061 1.000 13.46441 ? 7   ASN A N   1 
ATOM   53   C CA  . ASN A 1 7   ? -5.42255  20.32296 -18.05624 1.000 12.97863 ? 7   ASN A CA  1 
ATOM   54   C C   . ASN A 1 7   ? -5.22821  21.63301 -18.80718 1.000 14.54830 ? 7   ASN A C   1 
ATOM   55   O O   . ASN A 1 7   ? -5.08248  21.62084 -20.02501 1.000 19.00452 ? 7   ASN A O   1 
ATOM   56   C CB  . ASN A 1 7   ? -4.47792  19.28615 -18.64555 1.000 13.75305 ? 7   ASN A CB  1 
ATOM   57   C CG  . ASN A 1 7   ? -3.05447  19.70400 -18.47878 1.000 17.14607 ? 7   ASN A CG  1 
ATOM   58   O OD1 . ASN A 1 7   ? -2.77716  20.51565 -17.62031 1.000 16.52123 ? 7   ASN A OD1 1 
ATOM   59   N ND2 . ASN A 1 7   ? -2.14927  19.14980 -19.27555 1.000 15.09828 ? 7   ASN A ND2 1 
ATOM   60   N N   . ARG A 1 8   ? -5.18108  22.74682 -18.08082 1.000 13.47616 ? 8   ARG A N   1 
ATOM   61   C CA  . ARG A 1 8   ? -4.84602  24.03108 -18.68192 1.000 15.77251 ? 8   ARG A CA  1 
ATOM   62   C C   . ARG A 1 8   ? -3.34565  24.34448 -18.60356 1.000 18.56776 ? 8   ARG A C   1 
ATOM   63   O O   . ARG A 1 8   ? -2.90137  25.39936 -19.08171 1.000 15.93329 ? 8   ARG A O   1 
ATOM   64   C CB  . ARG A 1 8   ? -5.67294  25.13382 -18.00322 1.000 15.51456 ? 8   ARG A CB  1 
ATOM   65   C CG  . ARG A 1 8   ? -5.68295  26.48171 -18.78037 1.000 17.84625 ? 8   ARG A CG  1 
ATOM   66   C CD  . ARG A 1 8   ? -6.69340  27.45184 -18.13591 1.000 17.61788 ? 8   ARG A CD  1 
ATOM   67   N NE  . ARG A 1 8   ? -8.07632  27.02752 -18.37575 1.000 17.92487 ? 8   ARG A NE  1 
ATOM   68   C CZ  . ARG A 1 8   ? -9.10119  27.32236 -17.58805 1.000 25.22242 ? 8   ARG A CZ  1 
ATOM   69   N NH1 . ARG A 1 8   ? -8.94393  28.02824 -16.45903 1.000 23.28893 ? 8   ARG A NH1 1 
ATOM   70   N NH2 . ARG A 1 8   ? -10.30422 26.84171 -17.88953 1.000 21.83356 ? 8   ARG A NH2 1 
ATOM   71   N N   . CYS A 1 9   ? -2.54207  23.45508 -18.03266 1.000 14.40330 ? 9   CYS A N   1 
ATOM   72   C CA  . CYS A 1 9   ? -1.09654  23.65963 -18.01698 1.000 13.69357 ? 9   CYS A CA  1 
ATOM   73   C C   . CYS A 1 9   ? -0.54480  23.61527 -19.43767 1.000 18.20358 ? 9   CYS A C   1 
ATOM   74   O O   . CYS A 1 9   ? -1.10611  22.96988 -20.34391 1.000 17.39655 ? 9   CYS A O   1 
ATOM   75   C CB  . CYS A 1 9   ? -0.40497  22.54812 -17.21315 1.000 14.25630 ? 9   CYS A CB  1 
ATOM   76   S SG  . CYS A 1 9   ? -1.07957  22.44637 -15.50932 1.000 16.34102 ? 9   CYS A SG  1 
ATOM   77   N N   . SER A 1 10  ? 0.62642   24.23489 -19.61971 1.000 16.72159 ? 10  SER A N   1 
ATOM   78   C CA  . SER A 1 10  ? 1.26593   24.12848 -20.93542 1.000 17.86241 ? 10  SER A CA  1 
ATOM   79   C C   . SER A 1 10  ? 2.00518   22.81009 -21.13961 1.000 25.43891 ? 10  SER A C   1 
ATOM   80   O O   . SER A 1 10  ? 2.49672   22.53182 -22.25011 1.000 27.21376 ? 10  SER A O   1 
ATOM   81   C CB  . SER A 1 10  ? 2.23250   25.32086 -21.13159 1.000 23.23342 ? 10  SER A CB  1 
ATOM   82   O OG  . SER A 1 10  ? 3.16683   25.30927 -20.06177 1.000 26.77296 ? 10  SER A OG  1 
ATOM   83   N N   . TYR A 1 11  ? 2.09855   21.98982 -20.10626 1.000 18.65422 ? 11  TYR A N   1 
ATOM   84   C CA  . TYR A 1 11  ? 2.75988   20.70101 -20.14739 1.000 16.01289 ? 11  TYR A CA  1 
ATOM   85   C C   . TYR A 1 11  ? 1.73737   19.58561 -19.93623 1.000 15.94595 ? 11  TYR A C   1 
ATOM   86   O O   . TYR A 1 11  ? 0.68080   19.80802 -19.34084 1.000 18.91869 ? 11  TYR A O   1 
ATOM   87   C CB  . TYR A 1 11  ? 3.85855   20.63228 -19.04065 1.000 20.22847 ? 11  TYR A CB  1 
ATOM   88   C CG  . TYR A 1 11  ? 3.45655   21.12530 -17.67311 1.000 21.16441 ? 11  TYR A CG  1 
ATOM   89   C CD1 . TYR A 1 11  ? 3.60647   22.46190 -17.31631 1.000 21.05246 ? 11  TYR A CD1 1 
ATOM   90   C CD2 . TYR A 1 11  ? 2.90233   20.26005 -16.71901 1.000 20.03104 ? 11  TYR A CD2 1 
ATOM   91   C CE1 . TYR A 1 11  ? 3.23043   22.91653 -16.04651 1.000 21.85043 ? 11  TYR A CE1 1 
ATOM   92   C CE2 . TYR A 1 11  ? 2.52316   20.70918 -15.46918 1.000 20.17957 ? 11  TYR A CE2 1 
ATOM   93   C CZ  . TYR A 1 11  ? 2.72389   22.00972 -15.11645 1.000 22.30186 ? 11  TYR A CZ  1 
ATOM   94   O OH  . TYR A 1 11  ? 2.34185   22.42439 -13.86144 1.000 22.91015 ? 11  TYR A OH  1 
ATOM   95   N N   . THR A 1 12  ? 2.10002   18.38650 -20.40785 1.000 16.47210 ? 12  THR A N   1 
ATOM   96   C CA  . THR A 1 12  ? 1.28673   17.18614 -20.21650 1.000 14.83014 ? 12  THR A CA  1 
ATOM   97   C C   . THR A 1 12  ? 1.26029   16.80097 -18.75574 1.000 18.02700 ? 12  THR A C   1 
ATOM   98   O O   . THR A 1 12  ? 2.28576   16.84639 -18.06973 1.000 17.95831 ? 12  THR A O   1 
ATOM   99   C CB  . THR A 1 12  ? 1.85219   16.04436 -21.04434 1.000 19.64207 ? 12  THR A CB  1 
ATOM   100  O OG1 . THR A 1 12  ? 1.84749   16.46130 -22.42611 1.000 22.25618 ? 12  THR A OG1 1 
ATOM   101  C CG2 . THR A 1 12  ? 0.99533   14.78395 -20.91661 1.000 16.15365 ? 12  THR A CG2 1 
ATOM   102  N N   . VAL A 1 13  ? 0.08003   16.40434 -18.27170 1.000 14.27767 ? 13  VAL A N   1 
ATOM   103  C CA  . VAL A 1 13  ? -0.02337  15.80601 -16.93889 1.000 13.26712 ? 13  VAL A CA  1 
ATOM   104  C C   . VAL A 1 13  ? -0.74788  14.48132 -17.10240 1.000 17.17446 ? 13  VAL A C   1 
ATOM   105  O O   . VAL A 1 13  ? -1.38437  14.20798 -18.12340 1.000 19.29911 ? 13  VAL A O   1 
ATOM   106  C CB  . VAL A 1 13  ? -0.74507  16.66695 -15.86996 1.000 18.81504 ? 13  VAL A CB  1 
ATOM   107  C CG1 . VAL A 1 13  ? -0.05553  18.03839 -15.72154 1.000 18.10552 ? 13  VAL A CG1 1 
ATOM   108  C CG2 . VAL A 1 13  ? -2.23510  16.79639 -16.18715 1.000 20.98212 ? 13  VAL A CG2 1 
ATOM   109  N N   . TRP A 1 14  ? -0.57233  13.62004 -16.10765 1.000 14.06229 ? 14  TRP A N   1 
ATOM   110  C CA  . TRP A 1 14  ? -1.26637  12.35008 -16.08009 1.000 13.85023 ? 14  TRP A CA  1 
ATOM   111  C C   . TRP A 1 14  ? -2.19672  12.41574 -14.88831 1.000 20.51225 ? 14  TRP A C   1 
ATOM   112  O O   . TRP A 1 14  ? -1.75986  12.31230 -13.73522 1.000 16.71407 ? 14  TRP A O   1 
ATOM   113  C CB  . TRP A 1 14  ? -0.28597  11.17440 -15.98170 1.000 17.05221 ? 14  TRP A CB  1 
ATOM   114  C CG  . TRP A 1 14  ? 0.42258   10.92114 -17.30397 1.000 16.42467 ? 14  TRP A CG  1 
ATOM   115  C CD1 . TRP A 1 14  ? 0.13914   9.92655  -18.19593 1.000 18.97955 ? 14  TRP A CD1 1 
ATOM   116  C CD2 . TRP A 1 14  ? 1.53064   11.64662 -17.84611 1.000 17.23803 ? 14  TRP A CD2 1 
ATOM   117  N NE1 . TRP A 1 14  ? 1.00796   9.97844  -19.25861 1.000 18.43438 ? 14  TRP A NE1 1 
ATOM   118  C CE2 . TRP A 1 14  ? 1.86382   11.03159 -19.08707 1.000 19.77345 ? 14  TRP A CE2 1 
ATOM   119  C CE3 . TRP A 1 14  ? 2.27442   12.75429 -17.41799 1.000 16.44113 ? 14  TRP A CE3 1 
ATOM   120  C CZ2 . TRP A 1 14  ? 2.90876   11.46322 -19.87096 1.000 18.42967 ? 14  TRP A CZ2 1 
ATOM   121  C CZ3 . TRP A 1 14  ? 3.29673   13.23248 -18.24707 1.000 20.00776 ? 14  TRP A CZ3 1 
ATOM   122  C CH2 . TRP A 1 14  ? 3.61773   12.57857 -19.44879 1.000 19.90493 ? 14  TRP A CH2 1 
ATOM   123  N N   . ALA A 1 15  ? -3.47254  12.64202 -15.16154 1.000 15.01725 ? 15  ALA A N   1 
ATOM   124  C CA  . ALA A 1 15  ? -4.44435  12.76104 -14.06656 1.000 13.91697 ? 15  ALA A CA  1 
ATOM   125  C C   . ALA A 1 15  ? -4.61657  11.39869 -13.41422 1.000 14.56346 ? 15  ALA A C   1 
ATOM   126  O O   . ALA A 1 15  ? -4.39748  10.35220 -14.04177 1.000 17.08638 ? 15  ALA A O   1 
ATOM   127  C CB  . ALA A 1 15  ? -5.80108  13.26083 -14.59580 1.000 15.01307 ? 15  ALA A CB  1 
ATOM   128  N N   . ALA A 1 16  ? -5.01558  11.41797 -12.14181 1.000 15.68963 ? 16  ALA A N   1 
ATOM   129  C CA  . ALA A 1 16  ? -5.24197  10.20168 -11.37685 1.000 18.33950 ? 16  ALA A CA  1 
ATOM   130  C C   . ALA A 1 16  ? -6.47040  10.41917 -10.51824 1.000 17.81370 ? 16  ALA A C   1 
ATOM   131  O O   . ALA A 1 16  ? -6.71090  11.53414 -10.04915 1.000 16.73337 ? 16  ALA A O   1 
ATOM   132  C CB  . ALA A 1 16  ? -4.00895  9.87467  -10.49618 1.000 16.73815 ? 16  ALA A CB  1 
ATOM   133  N N   . ALA A 1 17  ? -7.22782  9.34551  -10.25323 1.000 15.60367 ? 17  ALA A N   1 
ATOM   134  C CA  . ALA A 1 17  ? -8.42933  9.44644  -9.42812  1.000 15.99835 ? 17  ALA A CA  1 
ATOM   135  C C   . ALA A 1 17  ? -8.58999  8.12579  -8.67937  1.000 20.66187 ? 17  ALA A C   1 
ATOM   136  O O   . ALA A 1 17  ? -8.60292  7.06515  -9.30339  1.000 20.74154 ? 17  ALA A O   1 
ATOM   137  C CB  . ALA A 1 17  ? -9.68401  9.71196  -10.27550 1.000 19.94611 ? 17  ALA A CB  1 
ATOM   138  N N   . SER A 1 18  ? -8.68717  8.19046  -7.36182  1.000 15.90807 ? 18  SER A N   1 
ATOM   139  C CA  . SER A 1 18  ? -8.63515  6.98053  -6.53904  1.000 16.46416 ? 18  SER A CA  1 
ATOM   140  C C   . SER A 1 18  ? -9.40253  7.24984  -5.26377  1.000 20.39093 ? 18  SER A C   1 
ATOM   141  O O   . SER A 1 18  ? -9.47949  8.38920  -4.80687  1.000 17.73045 ? 18  SER A O   1 
ATOM   142  C CB  . SER A 1 18  ? -7.16599  6.61838  -6.18689  1.000 20.47812 ? 18  SER A CB  1 
ATOM   143  O OG  . SER A 1 18  ? -7.06990  5.49055  -5.30173  1.000 25.70707 ? 18  SER A OG  1 
ATOM   144  N N   . LYS A 1 19  ? -9.88818  6.18577  -4.62111  1.000 22.63735 ? 19  LYS A N   1 
ATOM   145  C CA  . LYS A 1 19  ? -10.33360 6.33696  -3.23559  1.000 20.81318 ? 19  LYS A CA  1 
ATOM   146  C C   . LYS A 1 19  ? -9.44384  5.55883  -2.27506  1.000 28.56004 ? 19  LYS A C   1 
ATOM   147  O O   . LYS A 1 19  ? -9.85091  5.28805  -1.14156  1.000 33.27004 ? 19  LYS A O   1 
ATOM   148  C CB  . LYS A 1 19  ? -11.82174 5.94899  -3.06349  1.000 24.75570 ? 19  LYS A CB  1 
ATOM   149  C CG  . LYS A 1 19  ? -12.18300 4.50619  -3.45591  1.000 30.97599 ? 19  LYS A CG  1 
ATOM   150  C CD  . LYS A 1 19  ? -13.68679 4.18059  -3.11591  1.000 32.01928 ? 19  LYS A CD  1 
ATOM   151  C CE  . LYS A 1 19  ? -13.97576 2.67781  -2.97250  1.000 48.41802 ? 19  LYS A CE  1 
ATOM   152  N NZ  . LYS A 1 19  ? -13.44805 2.10750  -1.68090  1.000 45.72394 ? 19  LYS A NZ  1 
ATOM   153  N N   . GLY A 1 20  ? -8.22916  5.19847  -2.69815  1.000 21.27220 ? 20  GLY A N   1 
ATOM   154  C CA  . GLY A 1 20  ? -7.24005  4.69107  -1.75815  1.000 25.86697 ? 20  GLY A CA  1 
ATOM   155  C C   . GLY A 1 20  ? -7.08976  3.18981  -1.85019  1.000 28.00390 ? 20  GLY A C   1 
ATOM   156  O O   . GLY A 1 20  ? -5.97466  2.66283  -1.81690  1.000 31.08143 ? 20  GLY A O   1 
ATOM   157  N N   . ASP A 1 21  ? -8.21249  2.48772  -2.01049  1.000 30.10017 ? 21  ASP A N   1 
ATOM   158  C CA  . ASP A 1 21  ? -8.17898  1.03989  -2.19477  1.000 29.38848 ? 21  ASP A CA  1 
ATOM   159  C C   . ASP A 1 21  ? -8.77237  0.62391  -3.53001  1.000 38.83239 ? 21  ASP A C   1 
ATOM   160  O O   . ASP A 1 21  ? -8.99924  -0.56544 -3.76521  1.000 35.69926 ? 21  ASP A O   1 
ATOM   161  C CB  . ASP A 1 21  ? -8.89856  0.35616  -1.02012  1.000 33.05507 ? 21  ASP A CB  1 
ATOM   162  C CG  . ASP A 1 21  ? -10.36520 0.73997  -0.91309  1.000 44.70992 ? 21  ASP A CG  1 
ATOM   163  O OD1 . ASP A 1 21  ? -10.85168 1.65690  -1.62640  1.000 35.79354 ? 21  ASP A OD1 1 
ATOM   164  O OD2 . ASP A 1 21  ? -11.06487 0.09035  -0.11085  1.000 57.11965 ? 21  ASP A OD2 1 
ATOM   165  N N   . ALA A 1 22  ? -9.00258  1.56608  -4.43008  1.000 24.00721 ? 22  ALA A N   1 
ATOM   166  C CA  . ALA A 1 22  ? -9.62073  1.25287  -5.70582  1.000 21.83975 ? 22  ALA A CA  1 
ATOM   167  C C   . ALA A 1 22  ? -9.48421  2.48049  -6.59414  1.000 20.91537 ? 22  ALA A C   1 
ATOM   168  O O   . ALA A 1 22  ? -9.52226  3.60599  -6.09500  1.000 23.73097 ? 22  ALA A O   1 
ATOM   169  C CB  . ALA A 1 22  ? -11.11172 0.93403  -5.53921  1.000 26.88717 ? 22  ALA A CB  1 
ATOM   170  N N   . ALA A 1 23  ? -9.42587  2.24252  -7.90430  1.000 21.33832 ? 23  ALA A N   1 
ATOM   171  C CA  . ALA A 1 23  ? -9.55124  3.32645  -8.88215  1.000 20.26807 ? 23  ALA A CA  1 
ATOM   172  C C   . ALA A 1 23  ? -10.94189 3.95425  -8.80308  1.000 33.22768 ? 23  ALA A C   1 
ATOM   173  O O   . ALA A 1 23  ? -11.92264 3.29749  -8.42687  1.000 27.43246 ? 23  ALA A O   1 
ATOM   174  C CB  . ALA A 1 23  ? -9.30482  2.79314  -10.28512 1.000 22.59780 ? 23  ALA A CB  1 
ATOM   175  N N   . LEU A 1 24  ? -11.02531 5.24651  -9.13621  1.000 20.47686 ? 24  LEU A N   1 
ATOM   176  C CA  . LEU A 1 24  ? -12.29122 5.86481  -9.51876  1.000 21.06608 ? 24  LEU A CA  1 
ATOM   177  C C   . LEU A 1 24  ? -12.35406 5.91463  -11.04492 1.000 22.59027 ? 24  LEU A C   1 
ATOM   178  O O   . LEU A 1 24  ? -11.42182 6.39905  -11.68580 1.000 22.61931 ? 24  LEU A O   1 
ATOM   179  C CB  . LEU A 1 24  ? -12.40959 7.28147  -8.94499  1.000 21.31767 ? 24  LEU A CB  1 
ATOM   180  C CG  . LEU A 1 24  ? -12.38791 7.33112  -7.40565  1.000 20.44023 ? 24  LEU A CG  1 
ATOM   181  C CD1 . LEU A 1 24  ? -12.59157 8.77731  -6.91936  1.000 21.78180 ? 24  LEU A CD1 1 
ATOM   182  C CD2 . LEU A 1 24  ? -13.50048 6.42275  -6.85644  1.000 25.95229 ? 24  LEU A CD2 1 
ATOM   183  N N   . ASP A 1 25  ? -13.45558 5.42802  -11.63665 1.000 22.84615 ? 25  ASP A N   1 
ATOM   184  C CA  . ASP A 1 25  ? -13.52137 5.34305  -13.09348 1.000 20.80451 ? 25  ASP A CA  1 
ATOM   185  C C   . ASP A 1 25  ? -12.28125 4.58781  -13.57403 1.000 22.35131 ? 25  ASP A C   1 
ATOM   186  O O   . ASP A 1 25  ? -11.88815 3.57844  -12.97351 1.000 23.57237 ? 25  ASP A O   1 
ATOM   187  C CB  . ASP A 1 25  ? -13.66738 6.74808  -13.70166 1.000 20.02558 ? 25  ASP A CB  1 
ATOM   188  C CG  . ASP A 1 25  ? -14.19352 6.74056  -15.13556 1.000 28.00243 ? 25  ASP A CG  1 
ATOM   189  O OD1 . ASP A 1 25  ? -13.43299 6.39163  -16.05763 1.000 29.26929 ? 25  ASP A OD1 1 
ATOM   190  O OD2 . ASP A 1 25  ? -15.35414 7.15630  -15.35136 1.000 24.32787 ? 25  ASP A OD2 1 
ATOM   191  N N   . ALA A 1 26  ? -11.65417 5.04250  -14.64081 1.000 20.12926 ? 26  ALA A N   1 
ATOM   192  C CA  . ALA A 1 26  ? -10.48775 4.34452  -15.15705 1.000 18.99079 ? 26  ALA A CA  1 
ATOM   193  C C   . ALA A 1 26  ? -9.24226  4.52533  -14.28306 1.000 26.90396 ? 26  ALA A C   1 
ATOM   194  O O   . ALA A 1 26  ? -8.25628  3.82796  -14.49293 1.000 29.75912 ? 26  ALA A O   1 
ATOM   195  C CB  . ALA A 1 26  ? -10.21291 4.83327  -16.58342 1.000 25.51231 ? 26  ALA A CB  1 
ATOM   196  N N   . GLY A 1 27  ? -9.24982  5.43146  -13.31293 1.000 20.67412 ? 27  GLY A N   1 
ATOM   197  C CA  . GLY A 1 27  ? -8.09727  5.59920  -12.41853 1.000 18.96267 ? 27  GLY A CA  1 
ATOM   198  C C   . GLY A 1 27  ? -6.99248  6.53424  -12.89495 1.000 23.76948 ? 27  GLY A C   1 
ATOM   199  O O   . GLY A 1 27  ? -6.31046  7.14118  -12.05628 1.000 21.56225 ? 27  GLY A O   1 
ATOM   200  N N   . GLY A 1 28  ? -6.78040  6.67899  -14.19611 1.000 19.51457 ? 28  GLY A N   1 
ATOM   201  C CA  . GLY A 1 28  ? -5.76443  7.62349  -14.63817 1.000 18.04732 ? 28  GLY A CA  1 
ATOM   202  C C   . GLY A 1 28  ? -5.79291  7.73932  -16.13698 1.000 18.96595 ? 28  GLY A C   1 
ATOM   203  O O   . GLY A 1 28  ? -6.32285  6.86694  -16.82393 1.000 22.34925 ? 28  GLY A O   1 
ATOM   204  N N   . ARG A 1 29  ? -5.24159  8.85078  -16.63749 1.000 16.73726 ? 29  ARG A N   1 
ATOM   205  C CA  . ARG A 1 29  ? -5.17234  9.04926  -18.07716 1.000 15.67770 ? 29  ARG A CA  1 
ATOM   206  C C   . ARG A 1 29  ? -4.20327  10.17453 -18.37346 1.000 18.19303 ? 29  ARG A C   1 
ATOM   207  O O   . ARG A 1 29  ? -4.07325  11.11638 -17.59158 1.000 18.29903 ? 29  ARG A O   1 
ATOM   208  C CB  . ARG A 1 29  ? -6.55921  9.43141  -18.63412 1.000 22.04345 ? 29  ARG A CB  1 
ATOM   209  C CG  . ARG A 1 29  ? -6.78903  8.96647  -20.04958 1.000 26.00925 ? 29  ARG A CG  1 
ATOM   210  C CD  . ARG A 1 29  ? -7.89764  9.82216  -20.62115 1.000 20.99790 ? 29  ARG A CD  1 
ATOM   211  N NE  . ARG A 1 29  ? -7.36063  11.03946 -21.21842 1.000 18.91349 ? 29  ARG A NE  1 
ATOM   212  C CZ  . ARG A 1 29  ? -8.07369  11.83216 -22.00751 1.000 23.20706 ? 29  ARG A CZ  1 
ATOM   213  N NH1 . ARG A 1 29  ? -9.36726  11.61164 -22.20731 1.000 21.31290 ? 29  ARG A NH1 1 
ATOM   214  N NH2 . ARG A 1 29  ? -7.46542  12.85659 -22.62901 1.000 23.09049 ? 29  ARG A NH2 1 
ATOM   215  N N   . GLN A 1 30  ? -3.59344  10.10481 -19.53882 1.000 16.59865 ? 30  GLN A N   1 
ATOM   216  C CA  . GLN A 1 30  ? -2.78207  11.22671 -20.01254 1.000 15.13346 ? 30  GLN A CA  1 
ATOM   217  C C   . GLN A 1 30  ? -3.66553  12.39155 -20.45538 1.000 21.84885 ? 30  GLN A C   1 
ATOM   218  O O   . GLN A 1 30  ? -4.66959  12.19918 -21.13158 1.000 21.00721 ? 30  GLN A O   1 
ATOM   219  C CB  . GLN A 1 30  ? -1.89448  10.76393 -21.17700 1.000 17.54914 ? 30  GLN A CB  1 
ATOM   220  C CG  . GLN A 1 30  ? -0.97388  11.87812 -21.69164 1.000 18.11363 ? 30  GLN A CG  1 
ATOM   221  C CD  . GLN A 1 30  ? -0.02352  11.34000 -22.78697 1.000 25.66137 ? 30  GLN A CD  1 
ATOM   222  O OE1 . GLN A 1 30  ? 0.42990   10.19915 -22.72359 1.000 28.47884 ? 30  GLN A OE1 1 
ATOM   223  N NE2 . GLN A 1 30  ? 0.25717   12.15436 -23.77167 1.000 26.52524 ? 30  GLN A NE2 1 
ATOM   224  N N   . LEU A 1 31  ? -3.29795  13.61454 -20.06905 1.000 15.77673 ? 31  LEU A N   1 
ATOM   225  C CA  . LEU A 1 31  ? -3.99474  14.82049 -20.53850 1.000 16.60419 ? 31  LEU A CA  1 
ATOM   226  C C   . LEU A 1 31  ? -2.93997  15.72576 -21.13707 1.000 18.56239 ? 31  LEU A C   1 
ATOM   227  O O   . LEU A 1 31  ? -2.15664  16.33585 -20.39681 1.000 16.84177 ? 31  LEU A O   1 
ATOM   228  C CB  . LEU A 1 31  ? -4.71061  15.58920 -19.40506 1.000 17.29186 ? 31  LEU A CB  1 
ATOM   229  C CG  . LEU A 1 31  ? -5.92049  14.93565 -18.77016 1.000 23.78957 ? 31  LEU A CG  1 
ATOM   230  C CD1 . LEU A 1 31  ? -6.43838  15.87964 -17.71016 1.000 24.86375 ? 31  LEU A CD1 1 
ATOM   231  C CD2 . LEU A 1 31  ? -6.97600  14.81283 -19.81130 1.000 29.56682 ? 31  LEU A CD2 1 
ATOM   232  N N   . ASN A 1 32  ? -2.93937  15.85679 -22.46105 1.000 16.87830 ? 32  ASN A N   1 
ATOM   233  C CA  . ASN A 1 32  ? -2.11605  16.89894 -23.05293 1.000 14.63522 ? 32  ASN A CA  1 
ATOM   234  C C   . ASN A 1 32  ? -2.69106  18.27762 -22.71928 1.000 17.95915 ? 32  ASN A C   1 
ATOM   235  O O   . ASN A 1 32  ? -3.83044  18.42923 -22.23713 1.000 16.85659 ? 32  ASN A O   1 
ATOM   236  C CB  . ASN A 1 32  ? -2.03384  16.68406 -24.57693 1.000 17.19838 ? 32  ASN A CB  1 
ATOM   237  C CG  . ASN A 1 32  ? -1.30693  15.40195 -24.91725 1.000 24.86005 ? 32  ASN A CG  1 
ATOM   238  O OD1 . ASN A 1 32  ? -0.41437  14.98048 -24.20092 1.000 27.67204 ? 32  ASN A OD1 1 
ATOM   239  N ND2 . ASN A 1 32  ? -1.69755  14.77048 -25.99574 1.000 32.54050 ? 32  ASN A ND2 1 
ATOM   240  N N   . SER A 1 33  ? -1.88752  19.30792 -22.97512 1.000 15.37640 ? 33  SER A N   1 
ATOM   241  C CA  . SER A 1 33  ? -2.31269  20.68265 -22.72028 1.000 14.82648 ? 33  SER A CA  1 
ATOM   242  C C   . SER A 1 33  ? -3.60856  21.00478 -23.44811 1.000 16.64719 ? 33  SER A C   1 
ATOM   243  O O   . SER A 1 33  ? -3.68107  20.90642 -24.67627 1.000 17.66302 ? 33  SER A O   1 
ATOM   244  C CB  . SER A 1 33  ? -1.22785  21.67346 -23.17191 1.000 17.69672 ? 33  SER A CB  1 
ATOM   245  O OG  . SER A 1 33  ? -1.69458  23.02002 -23.03220 1.000 19.71644 ? 33  SER A OG  1 
ATOM   246  N N   . GLY A 1 34  ? -4.63254  21.39163 -22.67468 1.000 14.74627 ? 34  GLY A N   1 
ATOM   247  C CA  . GLY A 1 34  ? -5.94567  21.68253 -23.19897 1.000 14.65992 ? 34  GLY A CA  1 
ATOM   248  C C   . GLY A 1 34  ? -6.95713  20.56053 -23.11277 1.000 18.45890 ? 34  GLY A C   1 
ATOM   249  O O   . GLY A 1 34  ? -8.16290  20.83216 -23.30025 1.000 17.97189 ? 34  GLY A O   1 
ATOM   250  N N   . GLU A 1 35  ? -6.52615  19.31088 -22.91686 1.000 15.06581 ? 35  GLU A N   1 
ATOM   251  C CA  . GLU A 1 35  ? -7.45956  18.19669 -22.96634 1.000 15.60286 ? 35  GLU A CA  1 
ATOM   252  C C   . GLU A 1 35  ? -8.32062  18.12614 -21.70294 1.000 17.15956 ? 35  GLU A C   1 
ATOM   253  O O   . GLU A 1 35  ? -7.94360  18.58954 -20.61165 1.000 16.58001 ? 35  GLU A O   1 
ATOM   254  C CB  . GLU A 1 35  ? -6.73957  16.84757 -23.12907 1.000 13.48129 ? 35  GLU A CB  1 
ATOM   255  C CG  . GLU A 1 35  ? -6.05486  16.74263 -24.53199 1.000 14.63549 ? 35  GLU A CG  1 
ATOM   256  C CD  . GLU A 1 35  ? -5.53806  15.38194 -24.84372 1.000 21.99398 ? 35  GLU A CD  1 
ATOM   257  O OE1 . GLU A 1 35  ? -5.06556  14.67953 -23.91946 1.000 18.00060 ? 35  GLU A OE1 1 
ATOM   258  O OE2 . GLU A 1 35  ? -5.62736  14.97281 -26.03232 1.000 22.62727 ? 35  GLU A OE2 1 
ATOM   259  N N   . SER A 1 36  ? -9.49596  17.55928 -21.87464 1.000 13.92429 ? 36  SER A N   1 
ATOM   260  C CA  . SER A 1 36  ? -10.46493 17.35649 -20.79322 1.000 16.83408 ? 36  SER A CA  1 
ATOM   261  C C   . SER A 1 36  ? -10.84759 15.88361 -20.72161 1.000 22.73181 ? 36  SER A C   1 
ATOM   262  O O   . SER A 1 36  ? -10.96960 15.19606 -21.74382 1.000 21.39161 ? 36  SER A O   1 
ATOM   263  C CB  . SER A 1 36  ? -11.77213 18.16462 -21.02653 1.000 17.94178 ? 36  SER A CB  1 
ATOM   264  O OG  . SER A 1 36  ? -11.49415 19.53368 -21.25586 1.000 18.38746 ? 36  SER A OG  1 
ATOM   265  N N   . TRP A 1 37  ? -11.06635 15.40333 -19.50870 1.000 16.09946 ? 37  TRP A N   1 
ATOM   266  C CA  . TRP A 1 37  ? -11.35618 13.98527 -19.30250 1.000 14.94482 ? 37  TRP A CA  1 
ATOM   267  C C   . TRP A 1 37  ? -12.53696 13.95010 -18.34804 1.000 20.29368 ? 37  TRP A C   1 
ATOM   268  O O   . TRP A 1 37  ? -12.47021 14.54868 -17.27924 1.000 18.38618 ? 37  TRP A O   1 
ATOM   269  C CB  . TRP A 1 37  ? -10.14721 13.26580 -18.70356 1.000 20.65163 ? 37  TRP A CB  1 
ATOM   270  C CG  . TRP A 1 37  ? -10.35548 11.83155 -18.32343 1.000 21.51768 ? 37  TRP A CG  1 
ATOM   271  C CD1 . TRP A 1 37  ? -11.08597 10.89624 -18.98337 1.000 23.59888 ? 37  TRP A CD1 1 
ATOM   272  C CD2 . TRP A 1 37  ? -9.77505  11.16595 -17.18461 1.000 19.30756 ? 37  TRP A CD2 1 
ATOM   273  N NE1 . TRP A 1 37  ? -10.98832 9.67661  -18.33270 1.000 25.68756 ? 37  TRP A NE1 1 
ATOM   274  C CE2 . TRP A 1 37  ? -10.19396 9.80962  -17.23079 1.000 21.13373 ? 37  TRP A CE2 1 
ATOM   275  C CE3 . TRP A 1 37  ? -8.96900  11.58607 -16.13475 1.000 20.57517 ? 37  TRP A CE3 1 
ATOM   276  C CZ2 . TRP A 1 37  ? -9.82957  8.88589  -16.25489 1.000 23.79873 ? 37  TRP A CZ2 1 
ATOM   277  C CZ3 . TRP A 1 37  ? -8.58752  10.65630 -15.16485 1.000 26.67369 ? 37  TRP A CZ3 1 
ATOM   278  C CH2 . TRP A 1 37  ? -9.02648  9.33216  -15.23167 1.000 23.97580 ? 37  TRP A CH2 1 
ATOM   279  N N   . THR A 1 38  ? -13.63712 13.32945 -18.76175 1.000 17.61795 ? 38  THR A N   1 
ATOM   280  C CA  . THR A 1 38  ? -14.83380 13.28418 -17.92204 1.000 18.03420 ? 38  THR A CA  1 
ATOM   281  C C   . THR A 1 38  ? -14.92935 11.90279 -17.26849 1.000 20.35779 ? 38  THR A C   1 
ATOM   282  O O   . THR A 1 38  ? -14.88146 10.87490 -17.97199 1.000 21.39197 ? 38  THR A O   1 
ATOM   283  C CB  . THR A 1 38  ? -16.07242 13.55387 -18.77846 1.000 28.14471 ? 38  THR A CB  1 
ATOM   284  O OG1 . THR A 1 38  ? -15.96568 14.85736 -19.34988 1.000 30.56387 ? 38  THR A OG1 1 
ATOM   285  C CG2 . THR A 1 38  ? -17.31676 13.48481 -17.93213 1.000 29.49246 ? 38  THR A CG2 1 
ATOM   286  N N   . ILE A 1 39  ? -15.02584 11.87361 -15.93822 1.000 19.05415 ? 39  ILE A N   1 
ATOM   287  C CA  . ILE A 1 39  ? -15.15874 10.61020 -15.23422 1.000 17.65906 ? 39  ILE A CA  1 
ATOM   288  C C   . ILE A 1 39  ? -16.46068 10.61657 -14.47594 1.000 22.54699 ? 39  ILE A C   1 
ATOM   289  O O   . ILE A 1 39  ? -17.01915 11.66052 -14.14811 1.000 20.83869 ? 39  ILE A O   1 
ATOM   290  C CB  . ILE A 1 39  ? -14.00351 10.32219 -14.26936 1.000 15.79263 ? 39  ILE A CB  1 
ATOM   291  C CG1 . ILE A 1 39  ? -13.96556 11.36321 -13.14078 1.000 16.74789 ? 39  ILE A CG1 1 
ATOM   292  C CG2 . ILE A 1 39  ? -12.67927 10.22074 -15.08763 1.000 21.05434 ? 39  ILE A CG2 1 
ATOM   293  C CD1 . ILE A 1 39  ? -12.92477 10.96197 -12.06867 1.000 23.86805 ? 39  ILE A CD1 1 
ATOM   294  N N   . ASN A 1 40  ? -16.93187 9.41505  -14.16369 1.000 22.41358 ? 40  ASN A N   1 
ATOM   295  C CA  A ASN A 1 40  ? -18.10377 9.24529  -13.33159 0.515 20.96293 ? 40  ASN A CA  1 
ATOM   296  C CA  B ASN A 1 40  ? -18.10918 9.24758  -13.32563 0.485 20.99160 ? 40  ASN A CA  1 
ATOM   297  C C   . ASN A 1 40  ? -17.66539 8.60191  -12.02310 1.000 20.51490 ? 40  ASN A C   1 
ATOM   298  O O   . ASN A 1 40  ? -16.94545 7.58608  -12.03929 1.000 24.28531 ? 40  ASN A O   1 
ATOM   299  C CB  A ASN A 1 40  ? -19.14361 8.38340  -14.05863 0.515 27.12397 ? 40  ASN A CB  1 
ATOM   300  C CB  B ASN A 1 40  ? -19.18958 8.37038  -13.98443 0.485 27.22324 ? 40  ASN A CB  1 
ATOM   301  C CG  A ASN A 1 40  ? -19.85031 9.16263  -15.15022 0.515 22.79782 ? 40  ASN A CG  1 
ATOM   302  C CG  B ASN A 1 40  ? -20.50107 8.33719  -13.15444 0.485 34.38860 ? 40  ASN A CG  1 
ATOM   303  O OD1 A ASN A 1 40  ? -20.68506 10.02700 -14.87565 0.515 31.10255 ? 40  ASN A OD1 1 
ATOM   304  O OD1 B ASN A 1 40  ? -21.31518 9.27228  -13.19678 0.485 37.70132 ? 40  ASN A OD1 1 
ATOM   305  N ND2 A ASN A 1 40  ? -19.44806 8.92995  -16.38862 0.515 34.01956 ? 40  ASN A ND2 1 
ATOM   306  N ND2 B ASN A 1 40  ? -20.68390 7.27347  -12.38434 0.485 33.54330 ? 40  ASN A ND2 1 
ATOM   307  N N   . VAL A 1 41  ? -18.11547 9.18083  -10.92031 1.000 21.25306 ? 41  VAL A N   1 
ATOM   308  C CA  . VAL A 1 41  ? -17.76708 8.72816  -9.58088  1.000 21.98390 ? 41  VAL A CA  1 
ATOM   309  C C   . VAL A 1 41  ? -19.05919 8.28330  -8.91487  1.000 22.86937 ? 41  VAL A C   1 
ATOM   310  O O   . VAL A 1 41  ? -20.03464 9.03600  -8.89198  1.000 24.87170 ? 41  VAL A O   1 
ATOM   311  C CB  . VAL A 1 41  ? -17.06312 9.84523  -8.79317  1.000 21.46891 ? 41  VAL A CB  1 
ATOM   312  C CG1 . VAL A 1 41  ? -16.80559 9.40603  -7.35488  1.000 22.51387 ? 41  VAL A CG1 1 
ATOM   313  C CG2 . VAL A 1 41  ? -15.70143 10.20675 -9.52176  1.000 22.37234 ? 41  VAL A CG2 1 
ATOM   314  N N   . GLU A 1 42  ? -19.05663 7.07081  -8.36405  1.000 24.64110 ? 42  GLU A N   1 
ATOM   315  C CA  . GLU A 1 42  ? -20.27973 6.53077  -7.76730  1.000 22.62657 ? 42  GLU A CA  1 
ATOM   316  C C   . GLU A 1 42  ? -20.77536 7.40252  -6.60962  1.000 24.21343 ? 42  GLU A C   1 
ATOM   317  O O   . GLU A 1 42  ? -19.97309 7.84820  -5.78477  1.000 24.52012 ? 42  GLU A O   1 
ATOM   318  C CB  . GLU A 1 42  ? -19.98762 5.12169  -7.25732  1.000 26.25520 ? 42  GLU A CB  1 
ATOM   319  C CG  . GLU A 1 42  ? -21.17317 4.43827  -6.63968  1.000 58.35910 ? 42  GLU A CG  1 
ATOM   320  C CD  . GLU A 1 42  ? -21.83271 3.47362  -7.59893  1.000 80.58982 ? 42  GLU A CD  1 
ATOM   321  O OE1 . GLU A 1 42  ? -22.56536 2.57481  -7.09926  1.000 65.08601 ? 42  GLU A OE1 1 
ATOM   322  O OE2 . GLU A 1 42  ? -21.60133 3.62129  -8.83717  1.000 66.25798 ? 42  GLU A OE2 1 
ATOM   323  N N   . PRO A 1 43  ? -22.08436 7.67296  -6.51896  1.000 24.17331 ? 43  PRO A N   1 
ATOM   324  C CA  . PRO A 1 43  ? -22.63308 8.34820  -5.33759  1.000 21.50681 ? 43  PRO A CA  1 
ATOM   325  C C   . PRO A 1 43  ? -22.21139 7.63706  -4.06467  1.000 24.32145 ? 43  PRO A C   1 
ATOM   326  O O   . PRO A 1 43  ? -21.98472 6.42304  -4.06153  1.000 23.70280 ? 43  PRO A O   1 
ATOM   327  C CB  . PRO A 1 43  ? -24.15173 8.22938  -5.52759  1.000 24.51916 ? 43  PRO A CB  1 
ATOM   328  C CG  . PRO A 1 43  ? -24.31726 8.06177  -7.00187  1.000 31.44147 ? 43  PRO A CG  1 
ATOM   329  C CD  . PRO A 1 43  ? -23.13473 7.28426  -7.46998  1.000 28.49696 ? 43  PRO A CD  1 
ATOM   330  N N   . GLY A 1 44  ? -22.07701 8.41667  -2.99468  1.000 22.88767 ? 44  GLY A N   1 
ATOM   331  C CA  . GLY A 1 44  ? -21.65550 7.85824  -1.71706  1.000 22.90877 ? 44  GLY A CA  1 
ATOM   332  C C   . GLY A 1 44  ? -20.17045 7.62826  -1.57156  1.000 31.55686 ? 44  GLY A C   1 
ATOM   333  O O   . GLY A 1 44  ? -19.73321 7.17399  -0.50984  1.000 26.31396 ? 44  GLY A O   1 
ATOM   334  N N   . THR A 1 45  ? -19.37497 7.94495  -2.58840  1.000 25.50455 ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? -17.93777 7.73070  -2.49368  1.000 20.14035 ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? -17.37695 8.59092  -1.38261  1.000 20.59836 ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? -17.63416 9.79771  -1.32587  1.000 23.49292 ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? -17.26680 8.10682  -3.81218  1.000 22.01135 ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? -17.64847 7.16064  -4.80486  1.000 24.68635 ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? -15.72547 8.11563  -3.65712  1.000 25.13915 ? 45  THR A CG2 1 
ATOM   341  N N   . ASN A 1 46  ? -16.62125 7.97144  -0.48490  1.000 19.87090 ? 46  ASN A N   1 
ATOM   342  C CA  . ASN A 1 46  ? -16.08403 8.68510  0.66575   1.000 23.93121 ? 46  ASN A CA  1 
ATOM   343  C C   . ASN A 1 46  ? -14.56175 8.65626  0.55797   1.000 23.26262 ? 46  ASN A C   1 
ATOM   344  O O   . ASN A 1 46  ? -13.98781 7.61106  0.25111   1.000 24.74847 ? 46  ASN A O   1 
ATOM   345  C CB  . ASN A 1 46  ? -16.59655 8.02493  1.94892   1.000 29.37870 ? 46  ASN A CB  1 
ATOM   346  C CG  . ASN A 1 46  ? -15.85647 8.45590  3.14158   1.000 51.91010 ? 46  ASN A CG  1 
ATOM   347  O OD1 . ASN A 1 46  ? -16.19014 9.47017  3.74776   1.000 57.13418 ? 46  ASN A OD1 1 
ATOM   348  N ND2 . ASN A 1 46  ? -14.82164 7.69251  3.50796   1.000 61.57618 ? 46  ASN A ND2 1 
ATOM   349  N N   . GLY A 1 47  ? -13.91989 9.80999  0.70689   1.000 23.28815 ? 47  GLY A N   1 
ATOM   350  C CA  . GLY A 1 47  ? -12.46596 9.81128  0.67012   1.000 21.58045 ? 47  GLY A CA  1 
ATOM   351  C C   . GLY A 1 47  ? -11.84188 9.68807  -0.70774  1.000 26.37440 ? 47  GLY A C   1 
ATOM   352  O O   . GLY A 1 47  ? -10.74552 9.11559  -0.84161  1.000 24.31532 ? 47  GLY A O   1 
ATOM   353  N N   . GLY A 1 48  ? -12.50867 10.19513 -1.74697  1.000 18.94721 ? 48  GLY A N   1 
ATOM   354  C CA  . GLY A 1 48  ? -11.90737 10.20514 -3.06608  1.000 13.19189 ? 48  GLY A CA  1 
ATOM   355  C C   . GLY A 1 48  ? -10.90316 11.35266 -3.19918  1.000 15.80197 ? 48  GLY A C   1 
ATOM   356  O O   . GLY A 1 48  ? -10.99943 12.38122 -2.52087  1.000 18.91811 ? 48  GLY A O   1 
ATOM   357  N N   . LYS A 1 49  ? -9.90793  11.14309 -4.06817  1.000 16.78328 ? 49  LYS A N   1 
ATOM   358  C CA  . LYS A 1 49  ? -8.93751  12.18753 -4.38187  1.000 17.17053 ? 49  LYS A CA  1 
ATOM   359  C C   . LYS A 1 49  ? -8.64662  12.19517 -5.87399  1.000 16.35683 ? 49  LYS A C   1 
ATOM   360  O O   . LYS A 1 49  ? -8.63409  11.14622 -6.52450  1.000 17.22629 ? 49  LYS A O   1 
ATOM   361  C CB  . LYS A 1 49  ? -7.62128  11.95682 -3.64448  1.000 15.13242 ? 49  LYS A CB  1 
ATOM   362  C CG  . LYS A 1 49  ? -7.84946  11.80851 -2.12863  1.000 19.70917 ? 49  LYS A CG  1 
ATOM   363  C CD  . LYS A 1 49  ? -6.51825  11.90669 -1.33815  1.000 20.77738 ? 49  LYS A CD  1 
ATOM   364  C CE  . LYS A 1 49  ? -6.65544  11.39566 0.11409   1.000 22.85988 ? 49  LYS A CE  1 
ATOM   365  N NZ  . LYS A 1 49  ? -7.46520  12.28488 0.94315   1.000 24.37306 ? 49  LYS A NZ  1 
ATOM   366  N N   . ILE A 1 50  ? -8.38913  13.39225 -6.39460  1.000 15.17307 ? 50  ILE A N   1 
ATOM   367  C CA  . ILE A 1 50  ? -7.89749  13.56614 -7.76783  1.000 14.27360 ? 50  ILE A CA  1 
ATOM   368  C C   . ILE A 1 50  ? -6.60745  14.36682 -7.68961  1.000 12.83496 ? 50  ILE A C   1 
ATOM   369  O O   . ILE A 1 50  ? -6.50901  15.29589 -6.88056  1.000 15.28328 ? 50  ILE A O   1 
ATOM   370  C CB  . ILE A 1 50  ? -8.95088  14.28845 -8.63573  1.000 18.29095 ? 50  ILE A CB  1 
ATOM   371  C CG1 . ILE A 1 50  ? -10.12185 13.30827 -8.86404  1.000 17.17488 ? 50  ILE A CG1 1 
ATOM   372  C CG2 . ILE A 1 50  ? -8.33112  14.84297 -9.96384  1.000 17.22874 ? 50  ILE A CG2 1 
ATOM   373  C CD1 . ILE A 1 50  ? -11.44403 14.03327 -9.39018  1.000 20.42797 ? 50  ILE A CD1 1 
ATOM   374  N N   . TRP A 1 51  ? -5.61323  13.99420 -8.50235  1.000 13.27858 ? 51  TRP A N   1 
ATOM   375  C CA  . TRP A 1 51  ? -4.35162  14.72348 -8.49147  1.000 14.20303 ? 51  TRP A CA  1 
ATOM   376  C C   . TRP A 1 51  ? -3.73513  14.60251 -9.86792  1.000 15.74081 ? 51  TRP A C   1 
ATOM   377  O O   . TRP A 1 51  ? -4.20415  13.82175 -10.70918 1.000 15.50898 ? 51  TRP A O   1 
ATOM   378  C CB  . TRP A 1 51  ? -3.38263  14.18659 -7.39601  1.000 14.64487 ? 51  TRP A CB  1 
ATOM   379  C CG  . TRP A 1 51  ? -2.84103  12.78584 -7.56260  1.000 14.96839 ? 51  TRP A CG  1 
ATOM   380  C CD1 . TRP A 1 51  ? -1.57107  12.42327 -7.98259  1.000 15.90578 ? 51  TRP A CD1 1 
ATOM   381  C CD2 . TRP A 1 51  ? -3.51018  11.56282 -7.22293  1.000 17.10594 ? 51  TRP A CD2 1 
ATOM   382  N NE1 . TRP A 1 51  ? -1.44741  11.04652 -7.97131  1.000 15.38620 ? 51  TRP A NE1 1 
ATOM   383  C CE2 . TRP A 1 51  ? -2.61083  10.50350 -7.48208  1.000 15.93729 ? 51  TRP A CE2 1 
ATOM   384  C CE3 . TRP A 1 51  ? -4.80676  11.26571 -6.78483  1.000 18.60125 ? 51  TRP A CE3 1 
ATOM   385  C CZ2 . TRP A 1 51  ? -2.96540  9.17429  -7.31744  1.000 18.55249 ? 51  TRP A CZ2 1 
ATOM   386  C CZ3 . TRP A 1 51  ? -5.15103  9.92591  -6.58149  1.000 19.99158 ? 51  TRP A CZ3 1 
ATOM   387  C CH2 . TRP A 1 51  ? -4.23795  8.90629  -6.85370  1.000 19.38011 ? 51  TRP A CH2 1 
ATOM   388  N N   . ALA A 1 52  ? -2.70270  15.43315 -10.10484 1.000 14.60440 ? 52  ALA A N   1 
ATOM   389  C CA  . ALA A 1 52  ? -1.91638  15.36876 -11.32855 1.000 13.31604 ? 52  ALA A CA  1 
ATOM   390  C C   . ALA A 1 52  ? -0.58454  14.72274 -11.02829 1.000 15.19356 ? 52  ALA A C   1 
ATOM   391  O O   . ALA A 1 52  ? -0.03871  14.86611 -9.93419  1.000 17.59571 ? 52  ALA A O   1 
ATOM   392  C CB  . ALA A 1 52  ? -1.68078  16.77776 -11.92025 1.000 17.49794 ? 52  ALA A CB  1 
ATOM   393  N N   . ARG A 1 53  ? -0.08230  13.97589 -12.00680 1.000 14.00547 ? 53  ARG A N   1 
ATOM   394  C CA  . ARG A 1 53  ? 1.27463   13.42099 -11.99189 1.000 16.20937 ? 53  ARG A CA  1 
ATOM   395  C C   . ARG A 1 53  ? 2.06374   14.07077 -13.11691 1.000 15.86484 ? 53  ARG A C   1 
ATOM   396  O O   . ARG A 1 53  ? 1.50741   14.35198 -14.18169 1.000 16.38364 ? 53  ARG A O   1 
ATOM   397  C CB  . ARG A 1 53  ? 1.23668   11.91135 -12.19081 1.000 14.53509 ? 53  ARG A CB  1 
ATOM   398  C CG  . ARG A 1 53  ? 0.49658   11.20380 -11.08237 1.000 14.78975 ? 53  ARG A CG  1 
ATOM   399  C CD  . ARG A 1 53  ? 0.14804   9.75796  -11.47944 1.000 13.49247 ? 53  ARG A CD  1 
ATOM   400  N NE  . ARG A 1 53  ? -0.82012  9.68606  -12.57164 1.000 16.93308 ? 53  ARG A NE  1 
ATOM   401  C CZ  . ARG A 1 53  ? -1.14357  8.52293  -13.13692 1.000 19.52564 ? 53  ARG A CZ  1 
ATOM   402  N NH1 . ARG A 1 53  ? -0.46315  7.40075  -12.85338 1.000 18.39872 ? 53  ARG A NH1 1 
ATOM   403  N NH2 . ARG A 1 53  ? -2.17097  8.47689  -13.98410 1.000 18.06160 ? 53  ARG A NH2 1 
ATOM   404  N N   . THR A 1 54  ? 3.36323   14.30155 -12.88076 1.000 16.00991 ? 54  THR A N   1 
ATOM   405  C CA  . THR A 1 54  ? 4.20980   14.98342 -13.85038 1.000 14.75644 ? 54  THR A CA  1 
ATOM   406  C C   . THR A 1 54  ? 5.37149   14.08037 -14.24756 1.000 18.82363 ? 54  THR A C   1 
ATOM   407  O O   . THR A 1 54  ? 5.78209   13.19987 -13.48156 1.000 18.52725 ? 54  THR A O   1 
ATOM   408  C CB  . THR A 1 54  ? 4.75158   16.30663 -13.35081 1.000 19.29709 ? 54  THR A CB  1 
ATOM   409  O OG1 . THR A 1 54  ? 5.52871   16.07315 -12.15929 1.000 18.51085 ? 54  THR A OG1 1 
ATOM   410  C CG2 . THR A 1 54  ? 3.56470   17.29979 -13.04636 1.000 19.29843 ? 54  THR A CG2 1 
ATOM   411  N N   . ASP A 1 55  ? 5.83034   14.27133 -15.49212 1.000 16.79994 ? 55  ASP A N   1 
ATOM   412  C CA  . ASP A 1 55  ? 7.01709   13.59953 -16.04741 1.000 18.78352 ? 55  ASP A CA  1 
ATOM   413  C C   . ASP A 1 55  ? 6.94170   12.08383 -15.89667 1.000 22.08180 ? 55  ASP A C   1 
ATOM   414  O O   . ASP A 1 55  ? 7.78539   11.44652 -15.25575 1.000 19.96166 ? 55  ASP A O   1 
ATOM   415  C CB  . ASP A 1 55  ? 8.28016   14.14875 -15.37988 1.000 21.10935 ? 55  ASP A CB  1 
ATOM   416  C CG  . ASP A 1 55  ? 8.55881   15.57222 -15.79990 1.000 33.26009 ? 55  ASP A CG  1 
ATOM   417  O OD1 . ASP A 1 55  ? 8.64140   15.80609 -17.01760 1.000 45.95225 ? 55  ASP A OD1 1 
ATOM   418  O OD2 . ASP A 1 55  ? 8.61354   16.44760 -14.92117 1.000 36.47307 ? 55  ASP A OD2 1 
ATOM   419  N N   . CYS A 1 56  ? 5.92845   11.51032 -16.53374 1.000 18.34896 ? 56  CYS A N   1 
ATOM   420  C CA  . CYS A 1 56  ? 5.65546   10.08405 -16.49900 1.000 18.76353 ? 56  CYS A CA  1 
ATOM   421  C C   . CYS A 1 56  ? 6.17381   9.43405  -17.76455 1.000 23.78534 ? 56  CYS A C   1 
ATOM   422  O O   . CYS A 1 56  ? 6.12634   10.03062 -18.84100 1.000 23.17525 ? 56  CYS A O   1 
ATOM   423  C CB  . CYS A 1 56  ? 4.15812   9.76362  -16.42594 1.000 17.12654 ? 56  CYS A CB  1 
ATOM   424  S SG  . CYS A 1 56  ? 3.32669   10.48367 -14.99180 1.000 19.20792 ? 56  CYS A SG  1 
ATOM   425  N N   . TYR A 1 57  ? 6.59093   8.18182  -17.63216 1.000 24.17644 ? 57  TYR A N   1 
ATOM   426  C CA  . TYR A 1 57  ? 6.85556   7.28463  -18.75891 1.000 24.00081 ? 57  TYR A CA  1 
ATOM   427  C C   . TYR A 1 57  ? 6.09022   5.99128  -18.51006 1.000 25.08505 ? 57  TYR A C   1 
ATOM   428  O O   . TYR A 1 57  ? 6.23995   5.37269  -17.45539 1.000 28.56208 ? 57  TYR A O   1 
ATOM   429  C CB  . TYR A 1 57  ? 8.37170   7.00489  -18.90810 1.000 26.50785 ? 57  TYR A CB  1 
ATOM   430  C CG  . TYR A 1 57  ? 9.12143   8.27076  -19.23735 1.000 35.79483 ? 57  TYR A CG  1 
ATOM   431  C CD1 . TYR A 1 57  ? 9.54997   9.11886  -18.22677 1.000 34.65419 ? 57  TYR A CD1 1 
ATOM   432  C CD2 . TYR A 1 57  ? 9.32305   8.68080  -20.57256 1.000 48.40296 ? 57  TYR A CD2 1 
ATOM   433  C CE1 . TYR A 1 57  ? 10.19658  10.33832 -18.51543 1.000 36.22022 ? 57  TYR A CE1 1 
ATOM   434  C CE2 . TYR A 1 57  ? 9.99425   9.89996  -20.87314 1.000 37.69484 ? 57  TYR A CE2 1 
ATOM   435  C CZ  . TYR A 1 57  ? 10.41295  10.71368 -19.83622 1.000 40.81325 ? 57  TYR A CZ  1 
ATOM   436  O OH  . TYR A 1 57  ? 11.04222  11.91438 -20.05396 1.000 47.90490 ? 57  TYR A OH  1 
ATOM   437  N N   . PHE A 1 58  ? 5.28719   5.55365  -19.49040 1.000 28.75191 ? 58  PHE A N   1 
ATOM   438  C CA  . PHE A 1 58  ? 4.55165   4.30654  -19.36398 1.000 25.67320 ? 58  PHE A CA  1 
ATOM   439  C C   . PHE A 1 58  ? 4.77932   3.44104  -20.60016 1.000 29.88175 ? 58  PHE A C   1 
ATOM   440  O O   . PHE A 1 58  ? 4.91586   3.94827  -21.71258 1.000 34.26081 ? 58  PHE A O   1 
ATOM   441  C CB  . PHE A 1 58  ? 3.04274   4.54310  -19.19242 1.000 22.97265 ? 58  PHE A CB  1 
ATOM   442  C CG  . PHE A 1 58  ? 2.69399   5.20833  -17.90028 1.000 23.54026 ? 58  PHE A CG  1 
ATOM   443  C CD1 . PHE A 1 58  ? 2.76003   4.48363  -16.70638 1.000 23.47447 ? 58  PHE A CD1 1 
ATOM   444  C CD2 . PHE A 1 58  ? 2.30535   6.53943  -17.87671 1.000 21.09133 ? 58  PHE A CD2 1 
ATOM   445  C CE1 . PHE A 1 58  ? 2.48964   5.10129  -15.46281 1.000 22.74331 ? 58  PHE A CE1 1 
ATOM   446  C CE2 . PHE A 1 58  ? 1.99295   7.16046  -16.67117 1.000 21.92185 ? 58  PHE A CE2 1 
ATOM   447  C CZ  . PHE A 1 58  ? 2.08152   6.43542  -15.45005 1.000 21.32466 ? 58  PHE A CZ  1 
ATOM   448  N N   . ASP A 1 59  ? 4.79218   2.13558  -20.39874 1.000 39.94462 ? 59  ASP A N   1 
ATOM   449  C CA  . ASP A 1 59  ? 4.90368   1.25472  -21.54903 1.000 41.14686 ? 59  ASP A CA  1 
ATOM   450  C C   . ASP A 1 59  ? 3.51229   0.90823  -22.09280 1.000 46.62721 ? 59  ASP A C   1 
ATOM   451  O O   . ASP A 1 59  ? 2.47782   1.35374  -21.57581 1.000 35.81024 ? 59  ASP A O   1 
ATOM   452  C CB  . ASP A 1 59  ? 5.71728   0.01577  -21.17162 1.000 31.08187 ? 59  ASP A CB  1 
ATOM   453  C CG  . ASP A 1 59  ? 5.01587   -0.87741 -20.16075 1.000 41.18577 ? 59  ASP A CG  1 
ATOM   454  O OD1 . ASP A 1 59  ? 3.78238   -0.77930 -19.98550 1.000 38.50694 ? 59  ASP A OD1 1 
ATOM   455  O OD2 . ASP A 1 59  ? 5.71984   -1.68035 -19.51258 1.000 51.89829 ? 59  ASP A OD2 1 
ATOM   456  N N   . ASP A 1 60  ? 3.48799   0.06809  -23.14322 1.000 47.60406 ? 60  ASP A N   1 
ATOM   457  C CA  . ASP A 1 60  ? 2.23299   -0.30847 -23.77884 1.000 49.25041 ? 60  ASP A CA  1 
ATOM   458  C C   . ASP A 1 60  ? 1.27342   -0.98794 -22.80280 1.000 41.69645 ? 60  ASP A C   1 
ATOM   459  O O   . ASP A 1 60  ? 0.05967   -0.95203 -23.02864 1.000 56.15219 ? 60  ASP A O   1 
ATOM   460  C CB  . ASP A 1 60  ? 2.51593   -1.20322 -24.99620 1.000 51.46502 ? 60  ASP A CB  1 
ATOM   461  N N   . SER A 1 61  ? 1.77571   -1.56749 -21.70448 1.000 44.15483 ? 61  SER A N   1 
ATOM   462  C CA  . SER A 1 61  ? 0.92298   -2.19683 -20.69072 1.000 44.96582 ? 61  SER A CA  1 
ATOM   463  C C   . SER A 1 61  ? 0.49485   -1.25967 -19.54135 1.000 52.98711 ? 61  SER A C   1 
ATOM   464  O O   . SER A 1 61  ? -0.16694  -1.72368 -18.60681 1.000 37.10860 ? 61  SER A O   1 
ATOM   465  C CB  . SER A 1 61  ? 1.62882   -3.42690 -20.09958 1.000 48.33652 ? 61  SER A CB  1 
ATOM   466  O OG  . SER A 1 61  ? 2.71305   -3.05161 -19.25152 1.000 58.73713 ? 61  SER A OG  1 
ATOM   467  N N   . GLY A 1 62  ? 0.84308   0.03260  -19.57041 1.000 37.65487 ? 62  GLY A N   1 
ATOM   468  C CA  . GLY A 1 62  ? 0.37095   0.93147  -18.52329 1.000 38.59042 ? 62  GLY A CA  1 
ATOM   469  C C   . GLY A 1 62  ? 1.22059   0.92722  -17.27071 1.000 30.95391 ? 62  GLY A C   1 
ATOM   470  O O   . GLY A 1 62  ? 0.75356   1.31483  -16.18981 1.000 32.38930 ? 62  GLY A O   1 
ATOM   471  N N   . SER A 1 63  ? 2.46820   0.50788  -17.38578 1.000 31.36524 ? 63  SER A N   1 
ATOM   472  C CA  . SER A 1 63  ? 3.35021   0.36816  -16.24802 1.000 28.10852 ? 63  SER A CA  1 
ATOM   473  C C   . SER A 1 63  ? 4.56263   1.26933  -16.47305 1.000 32.29507 ? 63  SER A C   1 
ATOM   474  O O   . SER A 1 63  ? 5.06341   1.39311  -17.59492 1.000 29.59352 ? 63  SER A O   1 
ATOM   475  C CB  . SER A 1 63  ? 3.71388   -1.12394 -16.09781 1.000 39.76919 ? 63  SER A CB  1 
ATOM   476  O OG  . SER A 1 63  ? 4.64998   -1.30867 -15.07089 1.000 53.84185 ? 63  SER A OG  1 
ATOM   477  N N   . GLY A 1 64  ? 4.99560   1.96935  -15.42825 1.000 27.90515 ? 64  GLY A N   1 
ATOM   478  C CA  . GLY A 1 64  ? 6.03888   2.94536  -15.64274 1.000 27.14198 ? 64  GLY A CA  1 
ATOM   479  C C   . GLY A 1 64  ? 6.40721   3.69919  -14.38615 1.000 23.20115 ? 64  GLY A C   1 
ATOM   480  O O   . GLY A 1 64  ? 6.41600   3.11894  -13.30152 1.000 21.86519 ? 64  GLY A O   1 
ATOM   481  N N   . ILE A 1 65  ? 6.70577   4.98867  -14.51510 1.000 23.33278 ? 65  ILE A N   1 
ATOM   482  C CA  A ILE A 1 65  ? 7.15736   5.79992  -13.38706 0.533 19.89234 ? 65  ILE A CA  1 
ATOM   483  C CA  B ILE A 1 65  ? 7.11025   5.79588  -13.37353 0.467 19.88815 ? 65  ILE A CA  1 
ATOM   484  C C   . ILE A 1 65  ? 6.77244   7.24952  -13.66825 1.000 21.99374 ? 65  ILE A C   1 
ATOM   485  O O   . ILE A 1 65  ? 6.75398   7.67655  -14.81930 1.000 22.96663 ? 65  ILE A O   1 
ATOM   486  C CB  A ILE A 1 65  ? 8.68447   5.65397  -13.20507 0.533 19.19602 ? 65  ILE A CB  1 
ATOM   487  C CB  B ILE A 1 65  ? 8.61286   5.63966  -13.08085 0.467 18.95024 ? 65  ILE A CB  1 
ATOM   488  C CG1 A ILE A 1 65  ? 9.20795   6.49570  -12.03232 0.533 21.68749 ? 65  ILE A CG1 1 
ATOM   489  C CG1 B ILE A 1 65  ? 8.94760   6.30648  -11.75691 0.467 22.72750 ? 65  ILE A CG1 1 
ATOM   490  C CG2 A ILE A 1 65  ? 9.41420   6.02563  -14.52994 0.533 20.76904 ? 65  ILE A CG2 1 
ATOM   491  C CG2 B ILE A 1 65  ? 9.46613   6.23714  -14.23593 0.467 22.28624 ? 65  ILE A CG2 1 
ATOM   492  C CD1 A ILE A 1 65  ? 8.96629   5.89439  -10.62658 0.533 26.92482 ? 65  ILE A CD1 1 
ATOM   493  C CD1 B ILE A 1 65  ? 10.34822  6.10026  -11.34388 0.467 19.76553 ? 65  ILE A CD1 1 
ATOM   494  N N   . CYS A 1 66  ? 6.48106   8.01385  -12.59917 1.000 20.19971 ? 66  CYS A N   1 
ATOM   495  C CA  . CYS A 1 66  ? 6.25550   9.46219  -12.68650 1.000 19.16829 ? 66  CYS A CA  1 
ATOM   496  C C   . CYS A 1 66  ? 7.13096   10.12817 -11.64694 1.000 17.39072 ? 66  CYS A C   1 
ATOM   497  O O   . CYS A 1 66  ? 7.41621   9.52829  -10.61754 1.000 19.85689 ? 66  CYS A O   1 
ATOM   498  C CB  . CYS A 1 66  ? 4.77788   9.86882  -12.38346 1.000 17.07649 ? 66  CYS A CB  1 
ATOM   499  S SG  . CYS A 1 66  ? 3.57158   9.14120  -13.49560 1.000 19.36112 ? 66  CYS A SG  1 
ATOM   500  N N   . LYS A 1 67  ? 7.51860   11.38845 -11.89835 1.000 17.16463 ? 67  LYS A N   1 
ATOM   501  C CA  . LYS A 1 67  ? 8.36873   12.08678 -10.94001 1.000 17.30462 ? 67  LYS A CA  1 
ATOM   502  C C   . LYS A 1 67  ? 7.58048   12.71045 -9.80293  1.000 23.07673 ? 67  LYS A C   1 
ATOM   503  O O   . LYS A 1 67  ? 8.14124   12.92465 -8.71997  1.000 20.90318 ? 67  LYS A O   1 
ATOM   504  C CB  . LYS A 1 67  ? 9.19770   13.16682 -11.64767 1.000 17.83972 ? 67  LYS A CB  1 
ATOM   505  C CG  . LYS A 1 67  ? 10.18353  12.58273 -12.61996 1.000 22.53493 ? 67  LYS A CG  1 
ATOM   506  C CD  . LYS A 1 67  ? 11.30698  13.54442 -12.77422 1.000 23.47692 ? 67  LYS A CD  1 
ATOM   507  C CE  . LYS A 1 67  ? 12.35612  13.00842 -13.74520 1.000 31.27529 ? 67  LYS A CE  1 
ATOM   508  N NZ  . LYS A 1 67  ? 13.26858  14.12325 -14.15918 1.000 38.87180 ? 67  LYS A NZ  1 
ATOM   509  N N   . THR A 1 68  ? 6.28668   13.00081 -9.98900  1.000 15.86746 ? 68  THR A N   1 
ATOM   510  C CA  . THR A 1 68  ? 5.45635   13.37466 -8.84517  1.000 17.39686 ? 68  THR A CA  1 
ATOM   511  C C   . THR A 1 68  ? 4.16698   12.57467 -8.92015  1.000 19.53736 ? 68  THR A C   1 
ATOM   512  O O   . THR A 1 68  ? 3.66346   12.29508 -10.01857 1.000 16.74818 ? 68  THR A O   1 
ATOM   513  C CB  . THR A 1 68  ? 5.09121   14.88543 -8.77519  1.000 22.26006 ? 68  THR A CB  1 
ATOM   514  O OG1 . THR A 1 68  ? 4.32317   15.28572 -9.91436  1.000 16.19106 ? 68  THR A OG1 1 
ATOM   515  C CG2 . THR A 1 68  ? 6.32913   15.78129 -8.69102  1.000 17.51671 ? 68  THR A CG2 1 
ATOM   516  N N   . GLY A 1 69  ? 3.63806   12.21831 -7.74790  1.000 16.35612 ? 69  GLY A N   1 
ATOM   517  C CA  . GLY A 1 69  ? 2.35557   11.56932 -7.66893  1.000 16.64522 ? 69  GLY A CA  1 
ATOM   518  C C   . GLY A 1 69  ? 2.28086   10.14726 -8.15393  1.000 18.40248 ? 69  GLY A C   1 
ATOM   519  O O   . GLY A 1 69  ? 1.16822   9.64935  -8.31372  1.000 17.68864 ? 69  GLY A O   1 
ATOM   520  N N   . ASP A 1 70  ? 3.40622   9.45238  -8.33672  1.000 17.77294 ? 70  ASP A N   1 
ATOM   521  C CA  . ASP A 1 70  ? 3.37162   8.07032  -8.85286  1.000 15.67365 ? 70  ASP A CA  1 
ATOM   522  C C   . ASP A 1 70  ? 2.53623   7.15961  -7.93147  1.000 16.84798 ? 70  ASP A C   1 
ATOM   523  O O   . ASP A 1 70  ? 2.68146   7.20639  -6.70233  1.000 18.89969 ? 70  ASP A O   1 
ATOM   524  C CB  . ASP A 1 70  ? 4.81315   7.53730  -8.94222  1.000 17.44582 ? 70  ASP A CB  1 
ATOM   525  C CG  . ASP A 1 70  ? 4.90281   6.19542  -9.63567  1.000 24.22503 ? 70  ASP A CG  1 
ATOM   526  O OD1 . ASP A 1 70  ? 4.69341   6.15316  -10.85437 1.000 27.31188 ? 70  ASP A OD1 1 
ATOM   527  O OD2 . ASP A 1 70  ? 5.17035   5.19121  -8.93693  1.000 31.23862 ? 70  ASP A OD2 1 
ATOM   528  N N   . CYS A 1 71  ? 1.66167   6.32473  -8.51110  1.000 18.37944 ? 71  CYS A N   1 
ATOM   529  C CA  . CYS A 1 71  ? 0.78967   5.45221  -7.71110  1.000 20.87394 ? 71  CYS A CA  1 
ATOM   530  C C   . CYS A 1 71  ? 1.21416   4.01115  -7.97127  1.000 24.02859 ? 71  CYS A C   1 
ATOM   531  O O   . CYS A 1 71  ? 0.54963   3.27200  -8.69620  1.000 24.18354 ? 71  CYS A O   1 
ATOM   532  C CB  . CYS A 1 71  ? -0.69651  5.66570  -8.06168  1.000 20.12788 ? 71  CYS A CB  1 
ATOM   533  S SG  . CYS A 1 71  ? -1.03292  5.29644  -9.78878  1.000 21.75868 ? 71  CYS A SG  1 
ATOM   534  N N   . GLY A 1 72  ? 2.39270   3.66045  -7.46962  1.000 23.65041 ? 72  GLY A N   1 
ATOM   535  C CA  . GLY A 1 72  ? 2.89467   2.29703  -7.63228  1.000 26.44826 ? 72  GLY A CA  1 
ATOM   536  C C   . GLY A 1 72  ? 3.21213   1.94097  -9.06490  1.000 28.50702 ? 72  GLY A C   1 
ATOM   537  O O   . GLY A 1 72  ? 3.05791   0.78465  -9.46082  1.000 26.66211 ? 72  GLY A O   1 
ATOM   538  N N   . GLY A 1 73  ? 3.59995   2.91368  -9.87451  1.000 23.08356 ? 73  GLY A N   1 
ATOM   539  C CA  . GLY A 1 73  ? 4.04001   2.62622  -11.22432 1.000 26.04674 ? 73  GLY A CA  1 
ATOM   540  C C   . GLY A 1 73  ? 2.94554   2.36067  -12.24473 1.000 25.72848 ? 73  GLY A C   1 
ATOM   541  O O   . GLY A 1 73  ? 3.25930   1.92661  -13.35746 1.000 29.88629 ? 73  GLY A O   1 
ATOM   542  N N   . LEU A 1 74  ? 1.67856   2.58909  -11.91240 1.000 22.29482 ? 74  LEU A N   1 
ATOM   543  C CA  . LEU A 1 74  ? 0.56457   2.29481  -12.82329 1.000 21.65370 ? 74  LEU A CA  1 
ATOM   544  C C   . LEU A 1 74  ? 0.01742   3.56454  -13.48026 1.000 25.94390 ? 74  LEU A C   1 
ATOM   545  O O   . LEU A 1 74  ? -0.06235  4.61971  -12.84382 1.000 22.48637 ? 74  LEU A O   1 
ATOM   546  C CB  . LEU A 1 74  ? -0.58268  1.61213  -12.09255 1.000 24.18423 ? 74  LEU A CB  1 
ATOM   547  C CG  . LEU A 1 74  ? -0.18042  0.28874  -11.42056 1.000 33.45062 ? 74  LEU A CG  1 
ATOM   548  C CD1 . LEU A 1 74  ? -1.39065  -0.33668 -10.77150 1.000 30.49035 ? 74  LEU A CD1 1 
ATOM   549  C CD2 . LEU A 1 74  ? 0.44848   -0.64267 -12.42498 1.000 28.69756 ? 74  LEU A CD2 1 
ATOM   550  N N   . LEU A 1 75  ? -0.36462  3.45216  -14.74887 1.000 20.25980 ? 75  LEU A N   1 
ATOM   551  C CA  . LEU A 1 75  ? -1.08983  4.54658  -15.39401 1.000 21.62035 ? 75  LEU A CA  1 
ATOM   552  C C   . LEU A 1 75  ? -2.46023  4.70233  -14.75712 1.000 23.36228 ? 75  LEU A C   1 
ATOM   553  O O   . LEU A 1 75  ? -2.88118  5.81873  -14.42013 1.000 24.18400 ? 75  LEU A O   1 
ATOM   554  C CB  . LEU A 1 75  ? -1.21877  4.26997  -16.90060 1.000 27.82701 ? 75  LEU A CB  1 
ATOM   555  C CG  . LEU A 1 75  ? -2.17712  5.17217  -17.69466 1.000 32.35025 ? 75  LEU A CG  1 
ATOM   556  C CD1 . LEU A 1 75  ? -1.72591  6.63662  -17.65086 1.000 28.46615 ? 75  LEU A CD1 1 
ATOM   557  C CD2 . LEU A 1 75  ? -2.22147  4.70224  -19.14122 1.000 29.89125 ? 75  LEU A CD2 1 
ATOM   558  N N   . ARG A 1 76  ? -3.14442  3.57273  -14.50177 1.000 24.30990 ? 76  ARG A N   1 
ATOM   559  C CA  . ARG A 1 76  ? -4.48438  3.58092  -13.93173 1.000 25.48507 ? 76  ARG A CA  1 
ATOM   560  C C   . ARG A 1 76  ? -4.34668  3.34731  -12.44269 1.000 29.51849 ? 76  ARG A C   1 
ATOM   561  O O   . ARG A 1 76  ? -4.19786  2.21301  -11.99251 1.000 29.65087 ? 76  ARG A O   1 
ATOM   562  C CB  . ARG A 1 76  ? -5.36681  2.51946  -14.60630 1.000 24.20889 ? 76  ARG A CB  1 
ATOM   563  C CG  . ARG A 1 76  ? -5.56324  2.78952  -16.07825 1.000 29.98763 ? 76  ARG A CG  1 
ATOM   564  C CD  . ARG A 1 76  ? -6.48323  1.71850  -16.67659 1.000 39.94787 ? 76  ARG A CD  1 
ATOM   565  N NE  . ARG A 1 76  ? -6.01754  1.22929  -17.96643 1.000 67.25852 ? 76  ARG A NE  1 
ATOM   566  C CZ  . ARG A 1 76  ? -6.41036  1.71422  -19.13959 1.000 86.05286 ? 76  ARG A CZ  1 
ATOM   567  N NH1 . ARG A 1 76  ? -7.23032  2.75137  -19.22139 1.000 73.92716 ? 76  ARG A NH1 1 
ATOM   568  N NH2 . ARG A 1 76  ? -5.98111  1.13561  -20.25930 1.000 83.82231 ? 76  ARG A NH2 1 
ATOM   569  N N   . CYS A 1 77  ? -4.39944  4.43209  -11.66873 1.000 22.31216 ? 77  CYS A N   1 
ATOM   570  C CA  . CYS A 1 77  ? -4.12696  4.35493  -10.23734 1.000 19.69991 ? 77  CYS A CA  1 
ATOM   571  C C   . CYS A 1 77  ? -5.21509  3.61540  -9.48336  1.000 28.99303 ? 77  CYS A C   1 
ATOM   572  O O   . CYS A 1 77  ? -6.40028  3.94351  -9.61153  1.000 29.70452 ? 77  CYS A O   1 
ATOM   573  C CB  . CYS A 1 77  ? -4.02435  5.76448  -9.64269  1.000 20.96277 ? 77  CYS A CB  1 
ATOM   574  S SG  . CYS A 1 77  ? -2.52779  6.58453  -10.23888 1.000 21.36281 ? 77  CYS A SG  1 
ATOM   575  N N   . LYS A 1 78  ? -4.80055  2.65996  -8.64829  1.000 22.64719 ? 78  LYS A N   1 
ATOM   576  C CA  . LYS A 1 78  ? -5.69101  2.03735  -7.67175  1.000 25.30590 ? 78  LYS A CA  1 
ATOM   577  C C   . LYS A 1 78  ? -5.44418  2.53211  -6.26058  1.000 29.17963 ? 78  LYS A C   1 
ATOM   578  O O   . LYS A 1 78  ? -6.33081  2.39675  -5.41100  1.000 39.53462 ? 78  LYS A O   1 
ATOM   579  C CB  . LYS A 1 78  ? -5.54690  0.50017  -7.71551  1.000 35.31145 ? 78  LYS A CB  1 
ATOM   580  N N   . ARG A 1 79  ? -4.26997  3.11510  -5.98651  1.000 25.75260 ? 79  ARG A N   1 
ATOM   581  C CA  . ARG A 1 79  ? -3.88784  3.59906  -4.66440  1.000 22.52819 ? 79  ARG A CA  1 
ATOM   582  C C   . ARG A 1 79  ? -3.52109  5.07768  -4.79404  1.000 22.82166 ? 79  ARG A C   1 
ATOM   583  O O   . ARG A 1 79  ? -3.38053  5.59250  -5.91017  1.000 22.84954 ? 79  ARG A O   1 
ATOM   584  C CB  . ARG A 1 79  ? -2.68791  2.80558  -4.11239  1.000 25.56324 ? 79  ARG A CB  1 
ATOM   585  N N   . PHE A 1 80  ? -3.31418  5.75208  -3.65446  1.000 22.30257 ? 80  PHE A N   1 
ATOM   586  C CA  . PHE A 1 80  ? -2.92651  7.15929  -3.71769  1.000 22.08731 ? 80  PHE A CA  1 
ATOM   587  C C   . PHE A 1 80  ? -1.47625  7.32521  -4.16702  1.000 26.43923 ? 80  PHE A C   1 
ATOM   588  O O   . PHE A 1 80  ? -0.67237  6.38984  -4.15970  1.000 24.32024 ? 80  PHE A O   1 
ATOM   589  C CB  . PHE A 1 80  ? -3.12691  7.82361  -2.36957  1.000 18.71270 ? 80  PHE A CB  1 
ATOM   590  C CG  . PHE A 1 80  ? -4.56802  7.92396  -1.94615  1.000 19.95229 ? 80  PHE A CG  1 
ATOM   591  C CD1 . PHE A 1 80  ? -5.56954  8.33423  -2.83812  1.000 23.90751 ? 80  PHE A CD1 1 
ATOM   592  C CD2 . PHE A 1 80  ? -4.91456  7.64417  -0.63242  1.000 24.89687 ? 80  PHE A CD2 1 
ATOM   593  C CE1 . PHE A 1 80  ? -6.91411  8.43311  -2.41866  1.000 24.32174 ? 80  PHE A CE1 1 
ATOM   594  C CE2 . PHE A 1 80  ? -6.25306  7.75612  -0.19790  1.000 25.52165 ? 80  PHE A CE2 1 
ATOM   595  C CZ  . PHE A 1 80  ? -7.24179  8.13465  -1.10993  1.000 29.96078 ? 80  PHE A CZ  1 
ATOM   596  N N   . GLY A 1 81  ? -1.13509  8.56039  -4.54672  1.000 19.51331 ? 81  GLY A N   1 
ATOM   597  C CA  . GLY A 1 81  ? 0.13297   8.83678  -5.19297  1.000 18.59644 ? 81  GLY A CA  1 
ATOM   598  C C   . GLY A 1 81  ? 1.20339   9.29246  -4.20919  1.000 17.98456 ? 81  GLY A C   1 
ATOM   599  O O   . GLY A 1 81  ? 0.92704   9.74988  -3.09683  1.000 19.71162 ? 81  GLY A O   1 
ATOM   600  N N   . ARG A 1 82  ? 2.45108   9.15690  -4.64433  1.000 16.07743 ? 82  ARG A N   1 
ATOM   601  C CA  . ARG A 1 82  ? 3.59018   9.55642  -3.82166  1.000 18.24651 ? 82  ARG A CA  1 
ATOM   602  C C   . ARG A 1 82  ? 3.70958   11.07321 -3.79652  1.000 18.22776 ? 82  ARG A C   1 
ATOM   603  O O   . ARG A 1 82  ? 3.67633   11.71505 -4.86047  1.000 18.40198 ? 82  ARG A O   1 
ATOM   604  C CB  . ARG A 1 82  ? 4.86027   8.93937  -4.41245  1.000 19.25040 ? 82  ARG A CB  1 
ATOM   605  C CG  . ARG A 1 82  ? 6.13999   9.20499  -3.65678  1.000 26.06254 ? 82  ARG A CG  1 
ATOM   606  C CD  . ARG A 1 82  ? 7.24323   8.39769  -4.38583  1.000 32.46893 ? 82  ARG A CD  1 
ATOM   607  N NE  . ARG A 1 82  ? 8.44171   8.30069  -3.56625  1.000 49.23199 ? 82  ARG A NE  1 
ATOM   608  C CZ  . ARG A 1 82  ? 9.45430   9.15109  -3.63063  1.000 31.38578 ? 82  ARG A CZ  1 
ATOM   609  N NH1 . ARG A 1 82  ? 9.48800   10.11811 -4.53426  1.000 46.16014 ? 82  ARG A NH1 1 
ATOM   610  N NH2 . ARG A 1 82  ? 10.43423  9.06117  -2.74243  1.000 45.90940 ? 82  ARG A NH2 1 
ATOM   611  N N   . PRO A 1 83  ? 3.89403   11.68373 -2.63336  1.000 16.54606 ? 83  PRO A N   1 
ATOM   612  C CA  . PRO A 1 83  ? 4.05556   13.14247 -2.57628  1.000 13.95140 ? 83  PRO A CA  1 
ATOM   613  C C   . PRO A 1 83  ? 5.28303   13.58533 -3.34471  1.000 16.71441 ? 83  PRO A C   1 
ATOM   614  O O   . PRO A 1 83  ? 6.24185   12.82694 -3.49740  1.000 17.55884 ? 83  PRO A O   1 
ATOM   615  C CB  . PRO A 1 83  ? 4.23328   13.43212 -1.06877  1.000 17.94734 ? 83  PRO A CB  1 
ATOM   616  C CG  . PRO A 1 83  ? 3.61970   12.26276 -0.39665  1.000 23.97698 ? 83  PRO A CG  1 
ATOM   617  C CD  . PRO A 1 83  ? 3.81230   11.06987 -1.28765  1.000 18.04300 ? 83  PRO A CD  1 
ATOM   618  N N   . PRO A 1 84  ? 5.33563   14.82405 -3.77585  1.000 17.80136 ? 84  PRO A N   1 
ATOM   619  C CA  . PRO A 1 84  ? 4.38498   15.89595 -3.51676  1.000 15.17882 ? 84  PRO A CA  1 
ATOM   620  C C   . PRO A 1 84  ? 3.20035   15.87396 -4.50704  1.000 14.28564 ? 84  PRO A C   1 
ATOM   621  O O   . PRO A 1 84  ? 3.38776   15.69953 -5.72005  1.000 18.80593 ? 84  PRO A O   1 
ATOM   622  C CB  . PRO A 1 84  ? 5.25561   17.16341 -3.67508  1.000 16.01080 ? 84  PRO A CB  1 
ATOM   623  C CG  . PRO A 1 84  ? 6.33369   16.78795 -4.69553  1.000 19.45485 ? 84  PRO A CG  1 
ATOM   624  C CD  . PRO A 1 84  ? 6.56299   15.29112 -4.48420  1.000 21.40034 ? 84  PRO A CD  1 
ATOM   625  N N   . THR A 1 85  ? 1.98649   16.05875 -4.00497  1.000 13.65687 ? 85  THR A N   1 
ATOM   626  C CA  . THR A 1 85  ? 0.77627   16.05802 -4.82608  1.000 13.03656 ? 85  THR A CA  1 
ATOM   627  C C   . THR A 1 85  ? -0.19132  17.07231 -4.25026  1.000 12.58999 ? 85  THR A C   1 
ATOM   628  O O   . THR A 1 85  ? -0.70254  16.88139 -3.13862  1.000 15.87658 ? 85  THR A O   1 
ATOM   629  C CB  . THR A 1 85  ? 0.07211   14.69206 -4.79109  1.000 16.28248 ? 85  THR A CB  1 
ATOM   630  O OG1 . THR A 1 85  ? -0.09951  14.29041 -3.41776  1.000 18.45625 ? 85  THR A OG1 1 
ATOM   631  C CG2 . THR A 1 85  ? 0.86951   13.64142 -5.54389  1.000 17.29862 ? 85  THR A CG2 1 
ATOM   632  N N   . THR A 1 86  ? -0.52526  18.09421 -5.03030  1.000 14.93889 ? 86  THR A N   1 
ATOM   633  C CA  . THR A 1 86  ? -1.67783  18.92376 -4.66529  1.000 14.28875 ? 86  THR A CA  1 
ATOM   634  C C   . THR A 1 86  ? -2.92705  18.03879 -4.76985  1.000 15.34882 ? 86  THR A C   1 
ATOM   635  O O   . THR A 1 86  ? -3.06200  17.30247 -5.74638  1.000 16.70259 ? 86  THR A O   1 
ATOM   636  C CB  . THR A 1 86  ? -1.82400  20.08272 -5.65204  1.000 15.12366 ? 86  THR A CB  1 
ATOM   637  O OG1 . THR A 1 86  ? -0.55216  20.63159 -5.94565  1.000 14.68810 ? 86  THR A OG1 1 
ATOM   638  C CG2 . THR A 1 86  ? -2.76840  21.20563 -5.09650  1.000 15.08339 ? 86  THR A CG2 1 
ATOM   639  N N   . LEU A 1 87  ? -3.81879  18.07174 -3.77152  1.000 14.52101 ? 87  LEU A N   1 
ATOM   640  C CA  . LEU A 1 87  ? -4.92875  17.11466 -3.75311  1.000 14.06317 ? 87  LEU A CA  1 
ATOM   641  C C   . LEU A 1 87  ? -6.28153  17.79659 -3.81442  1.000 17.19041 ? 87  LEU A C   1 
ATOM   642  O O   . LEU A 1 87  ? -6.57787  18.66222 -2.98642  1.000 17.10247 ? 87  LEU A O   1 
ATOM   643  C CB  . LEU A 1 87  ? -4.87578  16.25168 -2.47407  1.000 14.62979 ? 87  LEU A CB  1 
ATOM   644  C CG  . LEU A 1 87  ? -3.67802  15.31472 -2.40414  1.000 15.77249 ? 87  LEU A CG  1 
ATOM   645  C CD1 . LEU A 1 87  ? -3.61344  14.71215 -0.99604  1.000 18.47585 ? 87  LEU A CD1 1 
ATOM   646  C CD2 . LEU A 1 87  ? -3.77445  14.24185 -3.47299  1.000 18.90897 ? 87  LEU A CD2 1 
ATOM   647  N N   . ALA A 1 88  ? -7.13638  17.33681 -4.73409  1.000 14.39897 ? 88  ALA A N   1 
ATOM   648  C CA  . ALA A 1 88  ? -8.56457  17.64051 -4.67929  1.000 12.95171 ? 88  ALA A CA  1 
ATOM   649  C C   . ALA A 1 88  ? -9.22443  16.48631 -3.93842  1.000 15.41666 ? 88  ALA A C   1 
ATOM   650  O O   . ALA A 1 88  ? -9.04512  15.33344 -4.32188  1.000 18.62496 ? 88  ALA A O   1 
ATOM   651  C CB  . ALA A 1 88  ? -9.16656  17.71809 -6.07461  1.000 15.86473 ? 88  ALA A CB  1 
ATOM   652  N N   . GLU A 1 89  ? -9.94310  16.78345 -2.86169  1.000 13.59551 ? 89  GLU A N   1 
ATOM   653  C CA  . GLU A 1 89  ? -10.45274 15.72714 -2.00287  1.000 11.64311 ? 89  GLU A CA  1 
ATOM   654  C C   . GLU A 1 89  ? -11.96163 15.86353 -1.88373  1.000 15.38528 ? 89  GLU A C   1 
ATOM   655  O O   . GLU A 1 89  ? -12.48299 16.98143 -1.79687  1.000 16.55211 ? 89  GLU A O   1 
ATOM   656  C CB  . GLU A 1 89  ? -9.86709  15.83249 -0.57573  1.000 14.76556 ? 89  GLU A CB  1 
ATOM   657  C CG  . GLU A 1 89  ? -8.31178  15.80688 -0.59194  1.000 18.80534 ? 89  GLU A CG  1 
ATOM   658  C CD  . GLU A 1 89  ? -7.74880  15.83513 0.82462   1.000 19.36521 ? 89  GLU A CD  1 
ATOM   659  O OE1 . GLU A 1 89  ? -8.14677  16.70013 1.61434   1.000 18.45955 ? 89  GLU A OE1 1 
ATOM   660  O OE2 . GLU A 1 89  ? -6.91481  15.00389 1.12957   1.000 19.90611 ? 89  GLU A OE2 1 
ATOM   661  N N   . PHE A 1 90  ? -12.66006 14.72200 -1.84190  1.000 17.92258 ? 90  PHE A N   1 
ATOM   662  C CA  . PHE A 1 90  ? -14.11506 14.84917 -1.79256  1.000 17.24525 ? 90  PHE A CA  1 
ATOM   663  C C   . PHE A 1 90  ? -14.74348 13.63650 -1.14047  1.000 17.90527 ? 90  PHE A C   1 
ATOM   664  O O   . PHE A 1 90  ? -14.26727 12.50919 -1.27947  1.000 18.24006 ? 90  PHE A O   1 
ATOM   665  C CB  . PHE A 1 90  ? -14.71681 15.04172 -3.20489  1.000 16.56606 ? 90  PHE A CB  1 
ATOM   666  C CG  . PHE A 1 90  ? -14.15042 14.09662 -4.22477  1.000 14.95595 ? 90  PHE A CG  1 
ATOM   667  C CD1 . PHE A 1 90  ? -12.97706 14.42481 -4.89917  1.000 19.00009 ? 90  PHE A CD1 1 
ATOM   668  C CD2 . PHE A 1 90  ? -14.71950 12.85728 -4.45040  1.000 18.56468 ? 90  PHE A CD2 1 
ATOM   669  C CE1 . PHE A 1 90  ? -12.38934 13.50284 -5.81808  1.000 21.15993 ? 90  PHE A CE1 1 
ATOM   670  C CE2 . PHE A 1 90  ? -14.16447 11.96590 -5.38203  1.000 23.96719 ? 90  PHE A CE2 1 
ATOM   671  C CZ  . PHE A 1 90  ? -13.00126 12.30766 -6.06514  1.000 21.55774 ? 90  PHE A CZ  1 
ATOM   672  N N   . SER A 1 91  ? -15.86261 13.88861 -0.45342  1.000 17.80704 ? 91  SER A N   1 
ATOM   673  C CA  . SER A 1 91  ? -16.72453 12.82296 0.03126   1.000 17.75765 ? 91  SER A CA  1 
ATOM   674  C C   . SER A 1 91  ? -18.12919 13.16746 -0.43144  1.000 15.73216 ? 91  SER A C   1 
ATOM   675  O O   . SER A 1 91  ? -18.57539 14.29226 -0.22676  1.000 20.86384 ? 91  SER A O   1 
ATOM   676  C CB  . SER A 1 91  ? -16.63519 12.73059 1.55075   1.000 22.72073 ? 91  SER A CB  1 
ATOM   677  O OG  . SER A 1 91  ? -15.34454 12.25040 1.89008   1.000 23.51812 ? 91  SER A OG  1 
ATOM   678  N N   . LEU A 1 92  ? -18.80485 12.22879 -1.10788  1.000 17.79198 ? 92  LEU A N   1 
ATOM   679  C CA  . LEU A 1 92  ? -20.07252 12.55329 -1.75852  1.000 18.19066 ? 92  LEU A CA  1 
ATOM   680  C C   . LEU A 1 92  ? -21.25854 11.90289 -1.03149  1.000 16.52282 ? 92  LEU A C   1 
ATOM   681  O O   . LEU A 1 92  ? -21.14431 10.77353 -0.53089  1.000 22.56674 ? 92  LEU A O   1 
ATOM   682  C CB  . LEU A 1 92  ? -20.06242 12.08129 -3.20730  1.000 19.40409 ? 92  LEU A CB  1 
ATOM   683  C CG  . LEU A 1 92  ? -18.81568 12.55296 -3.99496  1.000 19.80655 ? 92  LEU A CG  1 
ATOM   684  C CD1 . LEU A 1 92  ? -18.85700 11.93880 -5.41018  1.000 20.30843 ? 92  LEU A CD1 1 
ATOM   685  C CD2 . LEU A 1 92  ? -18.72910 14.04055 -4.01044  1.000 21.81534 ? 92  LEU A CD2 1 
ATOM   686  N N   . ASN A 1 93  ? -22.37831 12.62149 -1.01118  1.000 21.07778 ? 93  ASN A N   1 
ATOM   687  C CA  . ASN A 1 93  ? -23.66145 12.09613 -0.47591  1.000 22.01785 ? 93  ASN A CA  1 
ATOM   688  C C   . ASN A 1 93  ? -23.49842 11.61589 0.96033   1.000 24.66057 ? 93  ASN A C   1 
ATOM   689  O O   . ASN A 1 93  ? -23.76436 10.45282 1.27812   1.000 25.43612 ? 93  ASN A O   1 
ATOM   690  C CB  . ASN A 1 93  ? -24.20570 10.95111 -1.33302  1.000 19.06420 ? 93  ASN A CB  1 
ATOM   691  C CG  . ASN A 1 93  ? -24.27114 11.30909 -2.80604  1.000 22.48657 ? 93  ASN A CG  1 
ATOM   692  O OD1 . ASN A 1 93  ? -23.38520 10.91759 -3.56992  1.000 25.10922 ? 93  ASN A OD1 1 
ATOM   693  N ND2 . ASN A 1 93  ? -25.30851 12.05863 -3.20787  1.000 25.52746 ? 93  ASN A ND2 1 
ATOM   694  N N   . GLN A 1 94  ? -22.98569 12.48609 1.80677   1.000 20.29925 ? 94  GLN A N   1 
ATOM   695  C CA  . GLN A 1 94  ? -22.75633 12.13551 3.21250   1.000 24.72930 ? 94  GLN A CA  1 
ATOM   696  C C   . GLN A 1 94  ? -23.88290 12.80663 3.97629   1.000 21.76684 ? 94  GLN A C   1 
ATOM   697  O O   . GLN A 1 94  ? -23.84598 14.01315 4.22555   1.000 22.62859 ? 94  GLN A O   1 
ATOM   698  C CB  . GLN A 1 94  ? -21.39065 12.60241 3.71034   1.000 21.42830 ? 94  GLN A CB  1 
ATOM   699  C CG  . GLN A 1 94  ? -20.25735 12.00401 2.86043   1.000 28.39618 ? 94  GLN A CG  1 
ATOM   700  C CD  . GLN A 1 94  ? -20.13745 10.51185 3.04442   1.000 36.57070 ? 94  GLN A CD  1 
ATOM   701  O OE1 . GLN A 1 94  ? -19.96536 10.03717 4.16831   1.000 41.71493 ? 94  GLN A OE1 1 
ATOM   702  N NE2 . GLN A 1 94  ? -20.25826 9.74886  1.95278   1.000 31.97048 ? 94  GLN A NE2 1 
ATOM   703  N N   . TYR A 1 95  ? -24.91575 12.03023 4.31676   1.000 26.30231 ? 95  TYR A N   1 
ATOM   704  C CA  . TYR A 1 95  ? -26.08270 12.61404 4.99931   1.000 26.26225 ? 95  TYR A CA  1 
ATOM   705  C C   . TYR A 1 95  ? -26.63677 13.80581 4.22774   1.000 27.54518 ? 95  TYR A C   1 
ATOM   706  O O   . TYR A 1 95  ? -26.97341 14.84892 4.78870   1.000 27.82553 ? 95  TYR A O   1 
ATOM   707  C CB  . TYR A 1 95  ? -25.74044 12.98307 6.44711   1.000 27.29194 ? 95  TYR A CB  1 
ATOM   708  C CG  . TYR A 1 95  ? -25.34381 11.74885 7.19594   1.000 30.43347 ? 95  TYR A CG  1 
ATOM   709  C CD1 . TYR A 1 95  ? -26.31052 10.83215 7.63199   1.000 32.83338 ? 95  TYR A CD1 1 
ATOM   710  C CD2 . TYR A 1 95  ? -24.00090 11.45419 7.43535   1.000 41.26804 ? 95  TYR A CD2 1 
ATOM   711  C CE1 . TYR A 1 95  ? -25.94624 9.67742  8.31143   1.000 41.99872 ? 95  TYR A CE1 1 
ATOM   712  C CE2 . TYR A 1 95  ? -23.62495 10.29662 8.11042   1.000 44.07544 ? 95  TYR A CE2 1 
ATOM   713  C CZ  . TYR A 1 95  ? -24.60313 9.41734  8.55343   1.000 60.68854 ? 95  TYR A CZ  1 
ATOM   714  O OH  . TYR A 1 95  ? -24.23644 8.27239  9.22749   1.000 70.12541 ? 95  TYR A OH  1 
ATOM   715  N N   . GLY A 1 96  ? -26.73194 13.64155 2.90787   1.000 24.48506 ? 96  GLY A N   1 
ATOM   716  C CA  . GLY A 1 96  ? -27.36637 14.62490 2.06401   1.000 25.92485 ? 96  GLY A CA  1 
ATOM   717  C C   . GLY A 1 96  ? -26.45746 15.71095 1.52286   1.000 35.50935 ? 96  GLY A C   1 
ATOM   718  O O   . GLY A 1 96  ? -26.93667 16.58028 0.79240   1.000 27.30668 ? 96  GLY A O   1 
ATOM   719  N N   . LYS A 1 97  ? -25.15807 15.69164 1.83952   1.000 23.73914 ? 97  LYS A N   1 
ATOM   720  C CA  . LYS A 1 97  ? -24.26218 16.78949 1.46514   1.000 24.11287 ? 97  LYS A CA  1 
ATOM   721  C C   . LYS A 1 97  ? -23.02465 16.21695 0.80053   1.000 20.80703 ? 97  LYS A C   1 
ATOM   722  O O   . LYS A 1 97  ? -22.64122 15.07882 1.08780   1.000 22.42111 ? 97  LYS A O   1 
ATOM   723  C CB  . LYS A 1 97  ? -23.81612 17.60250 2.66910   1.000 34.29152 ? 97  LYS A CB  1 
ATOM   724  C CG  . LYS A 1 97  ? -24.97551 18.09075 3.55037   1.000 42.25796 ? 97  LYS A CG  1 
ATOM   725  C CD  . LYS A 1 97  ? -25.39465 19.51064 3.18518   1.000 41.31304 ? 97  LYS A CD  1 
ATOM   726  C CE  . LYS A 1 97  ? -26.10593 19.62814 1.84690   1.000 55.64654 ? 97  LYS A CE  1 
ATOM   727  N NZ  . LYS A 1 97  ? -26.89612 20.91285 1.75268   1.000 59.57362 ? 97  LYS A NZ  1 
ATOM   728  N N   . ASP A 1 98  ? -22.41062 17.00651 -0.09028  1.000 20.96125 ? 98  ASP A N   1 
ATOM   729  C CA  . ASP A 1 98  ? -21.05624 16.71080 -0.58799  1.000 21.42843 ? 98  ASP A CA  1 
ATOM   730  C C   . ASP A 1 98  ? -20.05742 17.62215 0.12469   1.000 16.97288 ? 98  ASP A C   1 
ATOM   731  O O   . ASP A 1 98  ? -20.37238 18.76985 0.46475   1.000 21.66502 ? 98  ASP A O   1 
ATOM   732  C CB  . ASP A 1 98  ? -20.89298 16.99786 -2.08528  1.000 19.52160 ? 98  ASP A CB  1 
ATOM   733  C CG  . ASP A 1 98  ? -21.69314 16.07445 -3.00373  1.000 23.40368 ? 98  ASP A CG  1 
ATOM   734  O OD1 . ASP A 1 98  ? -22.30341 15.09279 -2.54998  1.000 21.64756 ? 98  ASP A OD1 1 
ATOM   735  O OD2 . ASP A 1 98  ? -21.64823 16.34614 -4.24195  1.000 20.93691 ? 98  ASP A OD2 1 
ATOM   736  N N   . TYR A 1 99  ? -18.83087 17.11692 0.33376   1.000 19.41121 ? 99  TYR A N   1 
ATOM   737  C CA  . TYR A 1 99  ? -17.79642 17.92980 0.97940   1.000 21.67280 ? 99  TYR A CA  1 
ATOM   738  C C   . TYR A 1 99  ? -16.55830 17.90953 0.10076   1.000 19.19182 ? 99  TYR A C   1 
ATOM   739  O O   . TYR A 1 99  ? -16.08961 16.82546 -0.25264  1.000 20.08744 ? 99  TYR A O   1 
ATOM   740  C CB  . TYR A 1 99  ? -17.42261 17.38974 2.35764   1.000 20.61107 ? 99  TYR A CB  1 
ATOM   741  C CG  . TYR A 1 99  ? -18.57523 17.46741 3.34159   1.000 18.96537 ? 99  TYR A CG  1 
ATOM   742  C CD1 . TYR A 1 99  ? -18.85623 18.64173 4.00004   1.000 22.51496 ? 99  TYR A CD1 1 
ATOM   743  C CD2 . TYR A 1 99  ? -19.42320 16.38516 3.52370   1.000 28.21209 ? 99  TYR A CD2 1 
ATOM   744  C CE1 . TYR A 1 99  ? -19.94726 18.72566 4.88453   1.000 32.29529 ? 99  TYR A CE1 1 
ATOM   745  C CE2 . TYR A 1 99  ? -20.50281 16.45650 4.39487   1.000 30.68259 ? 99  TYR A CE2 1 
ATOM   746  C CZ  . TYR A 1 99  ? -20.74050 17.62496 5.07709   1.000 33.10337 ? 99  TYR A CZ  1 
ATOM   747  O OH  . TYR A 1 99  ? -21.80627 17.68984 5.94573   1.000 32.34531 ? 99  TYR A OH  1 
ATOM   748  N N   . ILE A 1 100 ? -16.03016 19.09064 -0.22603  1.000 19.51236 ? 100 ILE A N   1 
ATOM   749  C CA  . ILE A 1 100 ? -14.85801 19.17899 -1.10650  1.000 17.91005 ? 100 ILE A CA  1 
ATOM   750  C C   . ILE A 1 100 ? -13.80900 20.08033 -0.46558  1.000 15.01681 ? 100 ILE A C   1 
ATOM   751  O O   . ILE A 1 100 ? -14.11231 20.99216 0.30798   1.000 18.90489 ? 100 ILE A O   1 
ATOM   752  C CB  . ILE A 1 100 ? -15.20565 19.71530 -2.51323  1.000 19.13672 ? 100 ILE A CB  1 
ATOM   753  C CG1 . ILE A 1 100 ? -15.67181 21.19173 -2.46190  1.000 20.89689 ? 100 ILE A CG1 1 
ATOM   754  C CG2 . ILE A 1 100 ? -16.27390 18.78412 -3.15019  1.000 16.90474 ? 100 ILE A CG2 1 
ATOM   755  C CD1 . ILE A 1 100 ? -15.75380 21.84358 -3.87646  1.000 23.65886 ? 100 ILE A CD1 1 
ATOM   756  N N   . ASP A 1 101 ? -12.55302 19.81804 -0.81442  1.000 16.74478 ? 101 ASP A N   1 
ATOM   757  C CA  . ASP A 1 101 ? -11.48629 20.68853 -0.34323  1.000 15.14100 ? 101 ASP A CA  1 
ATOM   758  C C   . ASP A 1 101 ? -10.28657 20.46160 -1.23662  1.000 18.13755 ? 101 ASP A C   1 
ATOM   759  O O   . ASP A 1 101 ? -10.23944 19.50922 -2.01924  1.000 16.07755 ? 101 ASP A O   1 
ATOM   760  C CB  . ASP A 1 101 ? -11.12593 20.41831 1.12132   1.000 15.93830 ? 101 ASP A CB  1 
ATOM   761  C CG  . ASP A 1 101 ? -10.49217 19.03366 1.33024   1.000 21.18068 ? 101 ASP A CG  1 
ATOM   762  O OD1 . ASP A 1 101 ? -9.26969  18.83195 1.03942   1.000 19.17435 ? 101 ASP A OD1 1 
ATOM   763  O OD2 . ASP A 1 101 ? -11.19464 18.08556 1.75764   1.000 23.07342 ? 101 ASP A OD2 1 
ATOM   764  N N   . ILE A 1 102 ? -9.32836  21.37649 -1.12552  1.000 16.74961 ? 102 ILE A N   1 
ATOM   765  C CA  . ILE A 1 102 ? -7.99141  21.17613 -1.68003  1.000 11.72440 ? 102 ILE A CA  1 
ATOM   766  C C   . ILE A 1 102 ? -7.04186  21.10782 -0.49929  1.000 17.18551 ? 102 ILE A C   1 
ATOM   767  O O   . ILE A 1 102 ? -7.26203  21.77760 0.52559   1.000 18.29323 ? 102 ILE A O   1 
ATOM   768  C CB  . ILE A 1 102 ? -7.60643  22.31800 -2.63979  1.000 12.84698 ? 102 ILE A CB  1 
ATOM   769  C CG1 . ILE A 1 102 ? -8.40170  22.20754 -3.95442  1.000 15.75106 ? 102 ILE A CG1 1 
ATOM   770  C CG2 . ILE A 1 102 ? -6.10763  22.23346 -2.97698  1.000 19.50150 ? 102 ILE A CG2 1 
ATOM   771  C CD1 . ILE A 1 102 ? -8.18729  23.39413 -4.81755  1.000 21.64932 ? 102 ILE A CD1 1 
ATOM   772  N N   . SER A 1 103 ? -6.06392  20.21276 -0.59405  1.000 15.37119 ? 103 SER A N   1 
ATOM   773  C CA  . SER A 1 103 ? -5.13072  19.98008 0.50454   1.000 14.31776 ? 103 SER A CA  1 
ATOM   774  C C   . SER A 1 103 ? -3.70130  20.06307 -0.00815  1.000 16.79015 ? 103 SER A C   1 
ATOM   775  O O   . SER A 1 103 ? -3.40710  19.52094 -1.06954  1.000 15.86082 ? 103 SER A O   1 
ATOM   776  C CB  . SER A 1 103 ? -5.37375  18.59816 1.10069   1.000 16.42050 ? 103 SER A CB  1 
ATOM   777  O OG  . SER A 1 103 ? -4.38521  18.32405 2.08556   1.000 18.17780 ? 103 SER A OG  1 
ATOM   778  N N   . ASN A 1 104 ? -2.82205  20.73485 0.76825   1.000 13.81615 ? 104 ASN A N   1 
ATOM   779  C CA  . ASN A 1 104 ? -1.37155  20.69586 0.62138   1.000 13.97203 ? 104 ASN A CA  1 
ATOM   780  C C   . ASN A 1 104 ? -0.71031  19.84891 1.70113   1.000 14.38014 ? 104 ASN A C   1 
ATOM   781  O O   . ASN A 1 104 ? 0.49880   19.98356 1.93723   1.000 15.81216 ? 104 ASN A O   1 
ATOM   782  C CB  . ASN A 1 104 ? -0.80665  22.11655 0.68486   1.000 12.44050 ? 104 ASN A CB  1 
ATOM   783  C CG  . ASN A 1 104 ? -1.13629  22.93107 -0.56331  1.000 20.88630 ? 104 ASN A CG  1 
ATOM   784  O OD1 . ASN A 1 104 ? -1.05990  22.41402 -1.66229  1.000 20.42256 ? 104 ASN A OD1 1 
ATOM   785  N ND2 . ASN A 1 104 ? -1.44964  24.19621 -0.39226  1.000 18.25207 ? 104 ASN A ND2 1 
ATOM   786  N N   . ILE A 1 105 ? -1.48270  18.99647 2.38109   1.000 15.12935 ? 105 ILE A N   1 
ATOM   787  C CA  . ILE A 1 105 ? -0.89737  18.19904 3.47627   1.000 14.22186 ? 105 ILE A CA  1 
ATOM   788  C C   . ILE A 1 105 ? 0.11576   17.21517 2.95879   1.000 19.03377 ? 105 ILE A C   1 
ATOM   789  O O   . ILE A 1 105 ? 1.03151   16.80845 3.69850   1.000 15.16962 ? 105 ILE A O   1 
ATOM   790  C CB  . ILE A 1 105 ? -2.06306  17.51231 4.24423   1.000 18.73752 ? 105 ILE A CB  1 
ATOM   791  C CG1 . ILE A 1 105 ? -2.78573  18.57510 5.04946   1.000 22.22845 ? 105 ILE A CG1 1 
ATOM   792  C CG2 . ILE A 1 105 ? -1.60479  16.34314 5.14159   1.000 19.03888 ? 105 ILE A CG2 1 
ATOM   793  C CD1 . ILE A 1 105 ? -4.14646  18.04079 5.62004   1.000 21.95076 ? 105 ILE A CD1 1 
ATOM   794  N N   . LYS A 1 106 ? -0.01986  16.81389 1.69270   1.000 14.12140 ? 106 LYS A N   1 
ATOM   795  C CA  . LYS A 1 106 ? 0.92684   15.93268 1.02789   1.000 14.24299 ? 106 LYS A CA  1 
ATOM   796  C C   . LYS A 1 106 ? 1.73999   16.69586 0.00014   1.000 16.02194 ? 106 LYS A C   1 
ATOM   797  O O   . LYS A 1 106 ? 2.24879   16.10030 -0.96442  1.000 15.88727 ? 106 LYS A O   1 
ATOM   798  C CB  . LYS A 1 106 ? 0.20488   14.74153 0.35856   1.000 14.88620 ? 106 LYS A CB  1 
ATOM   799  C CG  . LYS A 1 106 ? -0.58769  13.88840 1.39047   1.000 22.64471 ? 106 LYS A CG  1 
ATOM   800  C CD  . LYS A 1 106 ? 0.42924   13.01684 2.09193   1.000 32.64376 ? 106 LYS A CD  1 
ATOM   801  C CE  . LYS A 1 106 ? -0.20005  12.08903 3.11714   1.000 42.76297 ? 106 LYS A CE  1 
ATOM   802  N NZ  . LYS A 1 106 ? 0.92486   11.35158 3.76827   1.000 43.15376 ? 106 LYS A NZ  1 
ATOM   803  N N   . GLY A 1 107 ? 1.89974   17.99328 0.21530   1.000 14.26786 ? 107 GLY A N   1 
ATOM   804  C CA  . GLY A 1 107 ? 2.80873   18.78109 -0.61837  1.000 11.93530 ? 107 GLY A CA  1 
ATOM   805  C C   . GLY A 1 107 ? 2.04131   19.35365 -1.80094  1.000 16.95466 ? 107 GLY A C   1 
ATOM   806  O O   . GLY A 1 107 ? 0.81117   19.24050 -1.89823  1.000 18.85281 ? 107 GLY A O   1 
ATOM   807  N N   . PHE A 1 108 ? 2.79274   19.89771 -2.74471  1.000 15.46581 ? 108 PHE A N   1 
ATOM   808  C CA  . PHE A 1 108 ? 2.20308   20.62936 -3.86937  1.000 15.97237 ? 108 PHE A CA  1 
ATOM   809  C C   . PHE A 1 108 ? 3.03012   20.30027 -5.10214  1.000 15.18573 ? 108 PHE A C   1 
ATOM   810  O O   . PHE A 1 108 ? 4.25128   20.35620 -5.06666  1.000 17.01048 ? 108 PHE A O   1 
ATOM   811  C CB  . PHE A 1 108 ? 2.19211   22.17565 -3.57561  1.000 15.83908 ? 108 PHE A CB  1 
ATOM   812  C CG  . PHE A 1 108 ? 1.76224   23.05718 -4.76301  1.000 11.08326 ? 108 PHE A CG  1 
ATOM   813  C CD1 . PHE A 1 108 ? 2.65634   23.35493 -5.83339  1.000 13.96529 ? 108 PHE A CD1 1 
ATOM   814  C CD2 . PHE A 1 108 ? 0.47204   23.61102 -4.77022  1.000 17.94736 ? 108 PHE A CD2 1 
ATOM   815  C CE1 . PHE A 1 108 ? 2.22668   24.15489 -6.91481  1.000 18.14348 ? 108 PHE A CE1 1 
ATOM   816  C CE2 . PHE A 1 108 ? 0.05349   24.45536 -5.80507  1.000 18.40095 ? 108 PHE A CE2 1 
ATOM   817  C CZ  . PHE A 1 108 ? 0.91785   24.72931 -6.87996  1.000 16.37920 ? 108 PHE A CZ  1 
ATOM   818  N N   . ASN A 1 109 ? 2.34721   19.96024 -6.22760  1.000 14.08033 ? 109 ASN A N   1 
ATOM   819  C CA  . ASN A 1 109 ? 3.12659   19.83580 -7.44452  1.000 13.50908 ? 109 ASN A CA  1 
ATOM   820  C C   . ASN A 1 109 ? 2.56419   20.68668 -8.56508  1.000 16.62672 ? 109 ASN A C   1 
ATOM   821  O O   . ASN A 1 109 ? 3.33784   21.31359 -9.30660  1.000 17.54849 ? 109 ASN A O   1 
ATOM   822  C CB  . ASN A 1 109 ? 3.21209   18.34503 -7.88221  1.000 16.44052 ? 109 ASN A CB  1 
ATOM   823  C CG  . ASN A 1 109 ? 1.85273   17.68641 -8.13615  1.000 17.54885 ? 109 ASN A CG  1 
ATOM   824  O OD1 . ASN A 1 109 ? 0.80979   18.15060 -7.69418  1.000 15.36522 ? 109 ASN A OD1 1 
ATOM   825  N ND2 . ASN A 1 109 ? 1.88090   16.58932 -8.91319  1.000 14.82755 ? 109 ASN A ND2 1 
ATOM   826  N N   . VAL A 1 110 ? 1.25100   20.73557 -8.70328  1.000 14.47516 ? 110 VAL A N   1 
ATOM   827  C CA  . VAL A 1 110 ? 0.60711   21.47125 -9.81027  1.000 13.90260 ? 110 VAL A CA  1 
ATOM   828  C C   . VAL A 1 110 ? -0.48241  22.37055 -9.23879  1.000 16.36351 ? 110 VAL A C   1 
ATOM   829  O O   . VAL A 1 110 ? -1.22100  21.93395 -8.33091  1.000 17.90852 ? 110 VAL A O   1 
ATOM   830  C CB  . VAL A 1 110 ? 0.02559   20.46121 -10.83966 1.000 21.50431 ? 110 VAL A CB  1 
ATOM   831  C CG1 . VAL A 1 110 ? -0.82048  21.15113 -11.89522 1.000 22.20231 ? 110 VAL A CG1 1 
ATOM   832  C CG2 . VAL A 1 110 ? 1.15730   19.61658 -11.50885 1.000 19.26907 ? 110 VAL A CG2 1 
ATOM   833  N N   . PRO A 1 111 ? -0.65921  23.60533 -9.73981  1.000 13.71140 ? 111 PRO A N   1 
ATOM   834  C CA  . PRO A 1 111 ? -1.74002  24.46846 -9.22245  1.000 14.80821 ? 111 PRO A CA  1 
ATOM   835  C C   . PRO A 1 111 ? -3.09155  23.93337 -9.68148  1.000 15.53007 ? 111 PRO A C   1 
ATOM   836  O O   . PRO A 1 111 ? -3.18926  23.28019 -10.73006 1.000 16.54004 ? 111 PRO A O   1 
ATOM   837  C CB  . PRO A 1 111 ? -1.44637  25.84168 -9.84001  1.000 18.22860 ? 111 PRO A CB  1 
ATOM   838  C CG  . PRO A 1 111 ? -0.54052  25.54256 -11.02867 1.000 22.95262 ? 111 PRO A CG  1 
ATOM   839  C CD  . PRO A 1 111 ? 0.20650   24.30249 -10.73671 1.000 17.15354 ? 111 PRO A CD  1 
ATOM   840  N N   . MET A 1 112 ? -4.12993  24.21067 -8.89020  1.000 17.52378 ? 112 MET A N   1 
ATOM   841  C CA  . MET A 1 112 ? -5.40404  23.51403 -9.10429  1.000 15.21947 ? 112 MET A CA  1 
ATOM   842  C C   . MET A 1 112 ? -6.57337  24.38906 -8.69589  1.000 17.23540 ? 112 MET A C   1 
ATOM   843  O O   . MET A 1 112 ? -6.49422  25.12827 -7.71312  1.000 16.82910 ? 112 MET A O   1 
ATOM   844  C CB  . MET A 1 112 ? -5.39622  22.21069 -8.25872  1.000 22.27610 ? 112 MET A CB  1 
ATOM   845  C CG  . MET A 1 112 ? -6.68249  21.48838 -8.16313  1.000 32.05867 ? 112 MET A CG  1 
ATOM   846  S SD  . MET A 1 112 ? -6.46414  20.23170 -6.85826  1.000 24.28276 ? 112 MET A SD  1 
ATOM   847  C CE  . MET A 1 112 ? -5.49729  19.08418 -7.77914  1.000 23.63954 ? 112 MET A CE  1 
ATOM   848  N N   . ASP A 1 113 ? -7.66537  24.30743 -9.45516  1.000 15.69175 ? 113 ASP A N   1 
ATOM   849  C CA  . ASP A 1 113 ? -8.95513  24.86098 -9.05170  1.000 15.60324 ? 113 ASP A CA  1 
ATOM   850  C C   . ASP A 1 113 ? -9.92825  23.68225 -8.97863  1.000 16.32019 ? 113 ASP A C   1 
ATOM   851  O O   . ASP A 1 113 ? -9.90160  22.78610 -9.83720  1.000 18.25857 ? 113 ASP A O   1 
ATOM   852  C CB  . ASP A 1 113 ? -9.44927  25.92617 -10.07482 1.000 17.07295 ? 113 ASP A CB  1 
ATOM   853  C CG  . ASP A 1 113 ? -10.83029 26.46947 -9.73505  1.000 22.78665 ? 113 ASP A CG  1 
ATOM   854  O OD1 . ASP A 1 113 ? -11.85820 25.80429 -10.01775 1.000 21.26552 ? 113 ASP A OD1 1 
ATOM   855  O OD2 . ASP A 1 113 ? -10.89391 27.55227 -9.13125  1.000 21.55306 ? 113 ASP A OD2 1 
ATOM   856  N N   . PHE A 1 114 ? -10.78597 23.67517 -7.95593  1.000 14.96493 ? 114 PHE A N   1 
ATOM   857  C CA  . PHE A 1 114 ? -11.75247 22.58930 -7.74438  1.000 15.82454 ? 114 PHE A CA  1 
ATOM   858  C C   . PHE A 1 114 ? -13.09390 23.27401 -7.50969  1.000 17.07450 ? 114 PHE A C   1 
ATOM   859  O O   . PHE A 1 114 ? -13.29950 23.86749 -6.44842  1.000 18.36290 ? 114 PHE A O   1 
ATOM   860  C CB  . PHE A 1 114 ? -11.33787 21.75769 -6.52186  1.000 13.57373 ? 114 PHE A CB  1 
ATOM   861  C CG  . PHE A 1 114 ? -12.14156 20.50935 -6.27873  1.000 14.02300 ? 114 PHE A CG  1 
ATOM   862  C CD1 . PHE A 1 114 ? -13.11778 20.04657 -7.16766  1.000 17.81390 ? 114 PHE A CD1 1 
ATOM   863  C CD2 . PHE A 1 114 ? -11.93709 19.80778 -5.07036  1.000 17.04734 ? 114 PHE A CD2 1 
ATOM   864  C CE1 . PHE A 1 114 ? -13.83982 18.84567 -6.90459  1.000 18.69332 ? 114 PHE A CE1 1 
ATOM   865  C CE2 . PHE A 1 114 ? -12.67391 18.62190 -4.75932  1.000 18.63969 ? 114 PHE A CE2 1 
ATOM   866  C CZ  . PHE A 1 114 ? -13.59160 18.10750 -5.69088  1.000 17.82236 ? 114 PHE A CZ  1 
ATOM   867  N N   . SER A 1 115 ? -13.98736 23.22629 -8.49407  1.000 16.17750 ? 115 SER A N   1 
ATOM   868  C CA  . SER A 1 115 ? -15.21364 24.02003 -8.44830  1.000 17.55004 ? 115 SER A CA  1 
ATOM   869  C C   . SER A 1 115 ? -16.41777 23.15837 -8.82563  1.000 19.71389 ? 115 SER A C   1 
ATOM   870  O O   . SER A 1 115 ? -16.29907 22.22739 -9.62775  1.000 19.92336 ? 115 SER A O   1 
ATOM   871  C CB  . SER A 1 115 ? -15.14046 25.20643 -9.40845  1.000 17.93035 ? 115 SER A CB  1 
ATOM   872  O OG  . SER A 1 115 ? -14.21487 26.17199 -8.96442  1.000 23.28433 ? 115 SER A OG  1 
ATOM   873  N N   . PRO A 1 116 ? -17.58193 23.42487 -8.23967  1.000 19.08062 ? 116 PRO A N   1 
ATOM   874  C CA  . PRO A 1 116 ? -18.80249 22.75442 -8.72544  1.000 17.97427 ? 116 PRO A CA  1 
ATOM   875  C C   . PRO A 1 116 ? -19.16868 23.29234 -10.08821 1.000 20.59285 ? 116 PRO A C   1 
ATOM   876  O O   . PRO A 1 116 ? -18.89342 24.45090 -10.41841 1.000 23.27709 ? 116 PRO A O   1 
ATOM   877  C CB  . PRO A 1 116 ? -19.85677 23.14178 -7.67812  1.000 18.94749 ? 116 PRO A CB  1 
ATOM   878  C CG  . PRO A 1 116 ? -19.41814 24.50068 -7.22647  1.000 22.05136 ? 116 PRO A CG  1 
ATOM   879  C CD  . PRO A 1 116 ? -17.85989 24.35973 -7.13400  1.000 17.15184 ? 116 PRO A CD  1 
ATOM   880  N N   . THR A 1 117 ? -19.81614 22.44428 -10.89100 1.000 20.49599 ? 117 THR A N   1 
ATOM   881  C CA  . THR A 1 117 ? -20.41886 22.90226 -12.15015 1.000 24.34695 ? 117 THR A CA  1 
ATOM   882  C C   . THR A 1 117 ? -21.92703 23.02105 -12.05355 1.000 27.47608 ? 117 THR A C   1 
ATOM   883  O O   . THR A 1 117 ? -22.56787 23.42159 -13.04240 1.000 29.42973 ? 117 THR A O   1 
ATOM   884  C CB  . THR A 1 117 ? -20.10202 21.95780 -13.29535 1.000 22.55561 ? 117 THR A CB  1 
ATOM   885  O OG1 . THR A 1 117 ? -20.54077 20.64198 -12.94974 1.000 25.08729 ? 117 THR A OG1 1 
ATOM   886  C CG2 . THR A 1 117 ? -18.57363 21.96458 -13.61040 1.000 21.19205 ? 117 THR A CG2 1 
ATOM   887  N N   . THR A 1 118 ? -22.49496 22.64508 -10.90890 1.000 24.47611 ? 118 THR A N   1 
ATOM   888  C CA  . THR A 1 118 ? -23.91051 22.78290 -10.56129 1.000 26.58119 ? 118 THR A CA  1 
ATOM   889  C C   . THR A 1 118 ? -24.03241 23.84377 -9.47250  1.000 29.79460 ? 118 THR A C   1 
ATOM   890  O O   . THR A 1 118 ? -23.03205 24.33533 -8.94644  1.000 30.81335 ? 118 THR A O   1 
ATOM   891  C CB  . THR A 1 118 ? -24.47402 21.43118 -10.12313 1.000 24.99059 ? 118 THR A CB  1 
ATOM   892  O OG1 . THR A 1 118 ? -23.64117 20.89545 -9.08196  1.000 28.81505 ? 118 THR A OG1 1 
ATOM   893  C CG2 . THR A 1 118 ? -24.49253 20.44171 -11.30734 1.000 31.48320 ? 118 THR A CG2 1 
ATOM   894  N N   . ARG A 1 119 ? -25.26694 24.23026 -9.12931  1.000 31.38463 ? 119 ARG A N   1 
ATOM   895  C CA  . ARG A 1 119 ? -25.42119 25.41611 -8.28621  1.000 28.59690 ? 119 ARG A CA  1 
ATOM   896  C C   . ARG A 1 119 ? -25.30001 25.07682 -6.80294  1.000 33.53277 ? 119 ARG A C   1 
ATOM   897  O O   . ARG A 1 119 ? -25.45514 23.92124 -6.38204  1.000 37.68690 ? 119 ARG A O   1 
ATOM   898  C CB  . ARG A 1 119 ? -26.78285 26.09453 -8.52645  1.000 41.56614 ? 119 ARG A CB  1 
ATOM   899  N N   . GLY A 1 120 ? -25.05664 26.11026 -5.98803  1.000 28.03621 ? 120 GLY A N   1 
ATOM   900  C CA  . GLY A 1 120 ? -25.27150 25.94233 -4.56400  1.000 33.16641 ? 120 GLY A CA  1 
ATOM   901  C C   . GLY A 1 120 ? -24.04594 25.94722 -3.67145  1.000 40.01831 ? 120 GLY A C   1 
ATOM   902  O O   . GLY A 1 120 ? -24.20462 25.81428 -2.45543  1.000 32.62536 ? 120 GLY A O   1 
ATOM   903  N N   . CYS A 1 121 ? -22.83776 26.06447 -4.21335  1.000 27.69197 ? 121 CYS A N   1 
ATOM   904  C CA  . CYS A 1 121 ? -21.67749 26.26814 -3.36011  1.000 27.09127 ? 121 CYS A CA  1 
ATOM   905  C C   . CYS A 1 121 ? -20.60249 26.90877 -4.22612  1.000 31.51537 ? 121 CYS A C   1 
ATOM   906  O O   . CYS A 1 121 ? -20.74710 27.02611 -5.44342  1.000 35.30729 ? 121 CYS A O   1 
ATOM   907  C CB  . CYS A 1 121 ? -21.20415 24.95275 -2.72691  1.000 24.48170 ? 121 CYS A CB  1 
ATOM   908  S SG  . CYS A 1 121 ? -21.06394 23.68342 -4.01442  1.000 26.55536 ? 121 CYS A SG  1 
ATOM   909  N N   . ARG A 1 122 ? -19.50825 27.26396 -3.58758  1.000 25.28629 ? 122 ARG A N   1 
ATOM   910  C CA  . ARG A 1 122 ? -18.38694 27.95303 -4.21233  1.000 29.39773 ? 122 ARG A CA  1 
ATOM   911  C C   . ARG A 1 122 ? -17.25283 26.95794 -4.43494  1.000 24.74965 ? 122 ARG A C   1 
ATOM   912  O O   . ARG A 1 122 ? -17.27757 25.82555 -3.93793  1.000 29.33564 ? 122 ARG A O   1 
ATOM   913  C CB  . ARG A 1 122 ? -17.88282 29.08816 -3.32014  1.000 34.06533 ? 122 ARG A CB  1 
ATOM   914  C CG  . ARG A 1 122 ? -17.24938 28.56630 -2.04140  1.000 39.31254 ? 122 ARG A CG  1 
ATOM   915  C CD  . ARG A 1 122 ? -16.71569 29.68688 -1.18838  1.000 55.26558 ? 122 ARG A CD  1 
ATOM   916  N NE  . ARG A 1 122 ? -15.67525 29.21964 -0.27926  1.000 69.42154 ? 122 ARG A NE  1 
ATOM   917  C CZ  . ARG A 1 122 ? -14.37477 29.22851 -0.55758  1.000 79.66989 ? 122 ARG A CZ  1 
ATOM   918  N NH1 . ARG A 1 122 ? -13.91514 29.64818 -1.72878  1.000 68.28488 ? 122 ARG A NH1 1 
ATOM   919  N NH2 . ARG A 1 122 ? -13.51074 28.81810 0.36650   1.000 66.13311 ? 122 ARG A NH2 1 
ATOM   920  N N   . GLY A 1 123 ? -16.29338 27.35597 -5.24899  1.000 22.72736 ? 123 GLY A N   1 
ATOM   921  C CA  . GLY A 1 123 ? -15.13503 26.52538 -5.49916  1.000 20.02626 ? 123 GLY A CA  1 
ATOM   922  C C   . GLY A 1 123 ? -13.96856 26.94078 -4.60760  1.000 24.53272 ? 123 GLY A C   1 
ATOM   923  O O   . GLY A 1 123 ? -14.02946 27.92087 -3.87539  1.000 25.10485 ? 123 GLY A O   1 
ATOM   924  N N   . VAL A 1 124 ? -12.88278 26.17093 -4.68804  1.000 19.55357 ? 124 VAL A N   1 
ATOM   925  C CA  . VAL A 1 124 ? -11.65141 26.48826 -3.96007  1.000 18.76403 ? 124 VAL A CA  1 
ATOM   926  C C   . VAL A 1 124 ? -10.48413 26.40669 -4.93177  1.000 21.82047 ? 124 VAL A C   1 
ATOM   927  O O   . VAL A 1 124 ? -10.52043 25.68247 -5.92450  1.000 19.77211 ? 124 VAL A O   1 
ATOM   928  C CB  . VAL A 1 124 ? -11.40819 25.54300 -2.76138  1.000 24.51145 ? 124 VAL A CB  1 
ATOM   929  C CG1 . VAL A 1 124 ? -12.33649 25.92808 -1.60694  1.000 32.86735 ? 124 VAL A CG1 1 
ATOM   930  C CG2 . VAL A 1 124 ? -11.62787 24.13158 -3.15257  1.000 28.10937 ? 124 VAL A CG2 1 
ATOM   931  N N   . ARG A 1 125 ? -9.40239  27.10334 -4.60135  1.000 17.92433 ? 125 ARG A N   1 
ATOM   932  C CA  . ARG A 1 125 ? -8.30835  27.16953 -5.56090  1.000 16.69902 ? 125 ARG A CA  1 
ATOM   933  C C   . ARG A 1 125 ? -6.99995  27.29299 -4.79354  1.000 24.05245 ? 125 ARG A C   1 
ATOM   934  O O   . ARG A 1 125 ? -6.95240  27.95870 -3.75654  1.000 23.46340 ? 125 ARG A O   1 
ATOM   935  C CB  . ARG A 1 125 ? -8.51957  28.38383 -6.48939  1.000 23.00494 ? 125 ARG A CB  1 
ATOM   936  C CG  . ARG A 1 125 ? -7.35948  28.72294 -7.41897  1.000 26.83413 ? 125 ARG A CG  1 
ATOM   937  C CD  . ARG A 1 125 ? -7.73290  29.94414 -8.32666  1.000 29.28376 ? 125 ARG A CD  1 
ATOM   938  N NE  . ARG A 1 125 ? -8.84791  29.60010 -9.20576  1.000 36.94686 ? 125 ARG A NE  1 
ATOM   939  C CZ  . ARG A 1 125 ? -9.12224  30.21304 -10.35118 1.000 50.67296 ? 125 ARG A CZ  1 
ATOM   940  N NH1 . ARG A 1 125 ? -8.40260  31.24270 -10.77471 1.000 45.34610 ? 125 ARG A NH1 1 
ATOM   941  N NH2 . ARG A 1 125 ? -10.12442 29.76332 -11.10563 1.000 35.82753 ? 125 ARG A NH2 1 
ATOM   942  N N   . CYS A 1 126 ? -5.94175  26.67427 -5.30815  1.000 16.83495 ? 126 CYS A N   1 
ATOM   943  C CA  . CYS A 1 126 ? -4.57712  26.98212 -4.85405  1.000 17.85826 ? 126 CYS A CA  1 
ATOM   944  C C   . CYS A 1 126 ? -3.75732  27.13025 -6.13009  1.000 20.85530 ? 126 CYS A C   1 
ATOM   945  O O   . CYS A 1 126 ? -3.41180  26.12018 -6.75955  1.000 19.86590 ? 126 CYS A O   1 
ATOM   946  C CB  . CYS A 1 126 ? -4.03137  25.88916 -3.94700  1.000 17.90644 ? 126 CYS A CB  1 
ATOM   947  S SG  . CYS A 1 126 ? -2.28922  26.11610 -3.51474  1.000 18.60328 ? 126 CYS A SG  1 
ATOM   948  N N   . ALA A 1 127 ? -3.46295  28.38822 -6.51378  1.000 18.26501 ? 127 ALA A N   1 
ATOM   949  C CA  . ALA A 1 127 ? -2.84929  28.66246 -7.81148  1.000 23.32400 ? 127 ALA A CA  1 
ATOM   950  C C   . ALA A 1 127 ? -1.56907  29.47231 -7.68059  1.000 27.33682 ? 127 ALA A C   1 
ATOM   951  O O   . ALA A 1 127 ? -1.00439  29.89364 -8.69357  1.000 29.64815 ? 127 ALA A O   1 
ATOM   952  C CB  . ALA A 1 127 ? -3.83531  29.37903 -8.73946  1.000 21.41736 ? 127 ALA A CB  1 
ATOM   953  N N   . ALA A 1 128 ? -1.06009  29.63857 -6.47489  1.000 21.57947 ? 128 ALA A N   1 
ATOM   954  C CA  . ALA A 1 128 ? 0.18234   30.36059 -6.25457  1.000 21.37385 ? 128 ALA A CA  1 
ATOM   955  C C   . ALA A 1 128 ? 1.37809   29.55163 -6.73263  1.000 23.70865 ? 128 ALA A C   1 
ATOM   956  O O   . ALA A 1 128 ? 1.31856   28.33081 -6.90476  1.000 20.49434 ? 128 ALA A O   1 
ATOM   957  C CB  . ALA A 1 128 ? 0.32508   30.67038 -4.75911  1.000 22.44670 ? 128 ALA A CB  1 
ATOM   958  N N   . ASP A 1 129 ? 2.50409   30.24373 -6.92122  1.000 21.26887 ? 129 ASP A N   1 
ATOM   959  C CA  . ASP A 1 129 ? 3.72420   29.58387 -7.36938  1.000 27.59993 ? 129 ASP A CA  1 
ATOM   960  C C   . ASP A 1 129 ? 4.44313   28.96630 -6.16704  1.000 23.32939 ? 129 ASP A C   1 
ATOM   961  O O   . ASP A 1 129 ? 5.51685   29.40202 -5.75076  1.000 20.71813 ? 129 ASP A O   1 
ATOM   962  C CB  . ASP A 1 129 ? 4.64478   30.57026 -8.07148  1.000 26.57087 ? 129 ASP A CB  1 
ATOM   963  C CG  . ASP A 1 129 ? 5.85355   29.89314 -8.69400  1.000 27.11204 ? 129 ASP A CG  1 
ATOM   964  O OD1 . ASP A 1 129 ? 5.91205   28.64106 -8.83022  1.000 27.28579 ? 129 ASP A OD1 1 
ATOM   965  O OD2 . ASP A 1 129 ? 6.78987   30.62743 -9.04009  1.000 33.14696 ? 129 ASP A OD2 1 
ATOM   966  N N   . ILE A 1 130 ? 3.82756   27.91462 -5.61133  1.000 18.68627 ? 130 ILE A N   1 
ATOM   967  C CA  . ILE A 1 130 ? 4.44559   27.26855 -4.47004  1.000 15.49477 ? 130 ILE A CA  1 
ATOM   968  C C   . ILE A 1 130 ? 5.75049   26.58378 -4.83085  1.000 18.44269 ? 130 ILE A C   1 
ATOM   969  O O   . ILE A 1 130 ? 6.67450   26.56624 -4.01554  1.000 22.68576 ? 130 ILE A O   1 
ATOM   970  C CB  . ILE A 1 130 ? 3.42589   26.31610 -3.83697  1.000 15.02256 ? 130 ILE A CB  1 
ATOM   971  C CG1 . ILE A 1 130 ? 2.36345   27.17167 -3.12148  1.000 20.29020 ? 130 ILE A CG1 1 
ATOM   972  C CG2 . ILE A 1 130 ? 4.12272   25.25212 -2.91303  1.000 19.65736 ? 130 ILE A CG2 1 
ATOM   973  C CD1 . ILE A 1 130 ? 1.31806   26.38170 -2.36009  1.000 22.55478 ? 130 ILE A CD1 1 
ATOM   974  N N   . VAL A 1 131 ? 5.88796   26.01171 -6.03929  1.000 14.87151 ? 131 VAL A N   1 
ATOM   975  C CA  . VAL A 1 131 ? 7.15168   25.36316 -6.33651  1.000 17.96858 ? 131 VAL A CA  1 
ATOM   976  C C   . VAL A 1 131 ? 8.27368   26.39178 -6.41616  1.000 23.34689 ? 131 VAL A C   1 
ATOM   977  O O   . VAL A 1 131 ? 9.38669   26.15715 -5.92035  1.000 21.28822 ? 131 VAL A O   1 
ATOM   978  C CB  . VAL A 1 131 ? 7.05527   24.55345 -7.63569  1.000 24.06416 ? 131 VAL A CB  1 
ATOM   979  C CG1 . VAL A 1 131 ? 8.40569   23.95796 -7.92820  1.000 23.01913 ? 131 VAL A CG1 1 
ATOM   980  C CG2 . VAL A 1 131 ? 6.03668   23.45431 -7.44775  1.000 21.27338 ? 131 VAL A CG2 1 
ATOM   981  N N   . GLY A 1 132 ? 8.01653   27.51319 -7.08658  1.000 20.14985 ? 132 GLY A N   1 
ATOM   982  C CA  . GLY A 1 132 ? 9.05895   28.51790 -7.23515  1.000 19.61921 ? 132 GLY A CA  1 
ATOM   983  C C   . GLY A 1 132 ? 9.51077   29.08937 -5.90382  1.000 27.89286 ? 132 GLY A C   1 
ATOM   984  O O   . GLY A 1 132 ? 10.69386  29.40792 -5.72090  1.000 25.45105 ? 132 GLY A O   1 
ATOM   985  N N   . GLN A 1 133 ? 8.58336   29.23670 -4.96011  1.000 18.32122 ? 133 GLN A N   1 
ATOM   986  C CA  . GLN A 1 133 ? 8.89484   29.88567 -3.67980  1.000 19.23770 ? 133 GLN A CA  1 
ATOM   987  C C   . GLN A 1 133 ? 9.26767   28.87408 -2.58465  1.000 21.26873 ? 133 GLN A C   1 
ATOM   988  O O   . GLN A 1 133 ? 9.56978   29.28006 -1.45080  1.000 19.34750 ? 133 GLN A O   1 
ATOM   989  C CB  . GLN A 1 133 ? 7.70199   30.70497 -3.17835  1.000 20.52588 ? 133 GLN A CB  1 
ATOM   990  C CG  . GLN A 1 133 ? 7.20262   31.81663 -4.08013  1.000 23.67271 ? 133 GLN A CG  1 
ATOM   991  C CD  . GLN A 1 133 ? 8.24050   32.88405 -4.32461  1.000 34.84396 ? 133 GLN A CD  1 
ATOM   992  O OE1 . GLN A 1 133 ? 9.32001   32.88679 -3.73151  1.000 27.32912 ? 133 GLN A OE1 1 
ATOM   993  N NE2 . GLN A 1 133 ? 7.93556   33.78147 -5.24028  1.000 44.49367 ? 133 GLN A NE2 1 
ATOM   994  N N   . CYS A 1 134 ? 9.26006   27.59344 -2.91176  1.000 19.13198 ? 134 CYS A N   1 
ATOM   995  C CA  . CYS A 1 134 ? 9.35674   26.51203 -1.92842  1.000 16.91437 ? 134 CYS A CA  1 
ATOM   996  C C   . CYS A 1 134 ? 10.63197  26.66150 -1.08904  1.000 21.19934 ? 134 CYS A C   1 
ATOM   997  O O   . CYS A 1 134 ? 11.72769  26.83745 -1.65079  1.000 20.50479 ? 134 CYS A O   1 
ATOM   998  C CB  . CYS A 1 134 ? 9.37652   25.17775 -2.69670  1.000 17.45953 ? 134 CYS A CB  1 
ATOM   999  S SG  . CYS A 1 134 ? 9.38625   23.66823 -1.64847  1.000 17.10139 ? 134 CYS A SG  1 
ATOM   1000 N N   . PRO A 1 135 ? 10.54201  26.55463 0.23175   1.000 19.61691 ? 135 PRO A N   1 
ATOM   1001 C CA  . PRO A 1 135 ? 11.76985  26.58267 1.06125   1.000 22.32484 ? 135 PRO A CA  1 
ATOM   1002 C C   . PRO A 1 135 ? 12.74721  25.51294 0.64515   1.000 21.87206 ? 135 PRO A C   1 
ATOM   1003 O O   . PRO A 1 135 ? 12.36270  24.40799 0.27323   1.000 18.42019 ? 135 PRO A O   1 
ATOM   1004 C CB  . PRO A 1 135 ? 11.24639  26.31899 2.47505   1.000 25.75587 ? 135 PRO A CB  1 
ATOM   1005 C CG  . PRO A 1 135 ? 9.78250   26.60412 2.42900   1.000 28.20688 ? 135 PRO A CG  1 
ATOM   1006 C CD  . PRO A 1 135 ? 9.31433   26.40985 1.03161   1.000 18.82812 ? 135 PRO A CD  1 
ATOM   1007 N N   . ALA A 1 136 ? 14.04749  25.82487 0.77925   1.000 22.11371 ? 136 ALA A N   1 
ATOM   1008 C CA  . ALA A 1 136 ? 15.09480  24.93009 0.28173   1.000 23.98456 ? 136 ALA A CA  1 
ATOM   1009 C C   . ALA A 1 136 ? 14.94306  23.49502 0.79687   1.000 19.17152 ? 136 ALA A C   1 
ATOM   1010 O O   . ALA A 1 136 ? 15.13047  22.51921 0.05370   1.000 22.59219 ? 136 ALA A O   1 
ATOM   1011 C CB  . ALA A 1 136 ? 16.46331  25.49804 0.71107   1.000 27.41317 ? 136 ALA A CB  1 
ATOM   1012 N N   . LYS A 1 137 ? 14.64103  23.33668 2.09194   1.000 18.22208 ? 137 LYS A N   1 
ATOM   1013 C CA  . LYS A 1 137 ? 14.62189  21.97954 2.63788   1.000 17.07786 ? 137 LYS A CA  1 
ATOM   1014 C C   . LYS A 1 137 ? 13.41999  21.17604 2.17300   1.000 19.91026 ? 137 LYS A C   1 
ATOM   1015 O O   . LYS A 1 137 ? 13.42857  19.94388 2.30658   1.000 23.22545 ? 137 LYS A O   1 
ATOM   1016 C CB  . LYS A 1 137 ? 14.63433  22.01418 4.16900   1.000 25.18611 ? 137 LYS A CB  1 
ATOM   1017 C CG  . LYS A 1 137 ? 15.99857  22.51899 4.70614   1.000 26.09343 ? 137 LYS A CG  1 
ATOM   1018 C CD  . LYS A 1 137 ? 16.05393  22.36062 6.21113   1.000 31.48328 ? 137 LYS A CD  1 
ATOM   1019 C CE  . LYS A 1 137 ? 17.36426  22.92320 6.79275   1.000 42.51199 ? 137 LYS A CE  1 
ATOM   1020 N NZ  . LYS A 1 137 ? 17.02226  23.82603 7.94901   1.000 55.62769 ? 137 LYS A NZ  1 
ATOM   1021 N N   . LEU A 1 138 ? 12.39904  21.82815 1.62886   1.000 17.23434 ? 138 LEU A N   1 
ATOM   1022 C CA  . LEU A 1 138 ? 11.21487  21.08337 1.15930   1.000 19.17967 ? 138 LEU A CA  1 
ATOM   1023 C C   . LEU A 1 138 ? 11.22482  20.81770 -0.34059  1.000 20.12529 ? 138 LEU A C   1 
ATOM   1024 O O   . LEU A 1 138 ? 10.32150  20.13738 -0.84646  1.000 19.77650 ? 138 LEU A O   1 
ATOM   1025 C CB  . LEU A 1 138 ? 9.93971   21.85183 1.50437   1.000 16.53607 ? 138 LEU A CB  1 
ATOM   1026 C CG  . LEU A 1 138 ? 9.70724   22.08226 2.99370   1.000 19.12518 ? 138 LEU A CG  1 
ATOM   1027 C CD1 . LEU A 1 138 ? 8.41168   22.79431 3.16658   1.000 18.31044 ? 138 LEU A CD1 1 
ATOM   1028 C CD2 . LEU A 1 138 ? 9.68463   20.74273 3.75097   1.000 17.06180 ? 138 LEU A CD2 1 
ATOM   1029 N N   . LYS A 1 139 ? 12.19953  21.35152 -1.07821  1.000 15.84560 ? 139 LYS A N   1 
ATOM   1030 C CA  . LYS A 1 139 ? 12.17370  21.18445 -2.52488  1.000 17.94598 ? 139 LYS A CA  1 
ATOM   1031 C C   . LYS A 1 139 ? 12.40455  19.73297 -2.88330  1.000 21.82129 ? 139 LYS A C   1 
ATOM   1032 O O   . LYS A 1 139 ? 13.28912  19.08007 -2.32870  1.000 25.62762 ? 139 LYS A O   1 
ATOM   1033 C CB  . LYS A 1 139 ? 13.25938  22.03236 -3.18242  1.000 23.18970 ? 139 LYS A CB  1 
ATOM   1034 C CG  . LYS A 1 139 ? 12.98787  23.48466 -3.18135  1.000 29.24081 ? 139 LYS A CG  1 
ATOM   1035 C CD  . LYS A 1 139 ? 14.18230  24.22898 -3.81295  1.000 48.81585 ? 139 LYS A CD  1 
ATOM   1036 C CE  . LYS A 1 139 ? 13.82066  25.64700 -4.21271  1.000 52.87842 ? 139 LYS A CE  1 
ATOM   1037 N NZ  . LYS A 1 139 ? 15.00007  26.45209 -4.65208  1.000 73.93624 ? 139 LYS A NZ  1 
ATOM   1038 N N   . ALA A 1 140 ? 11.60656  19.23498 -3.77506  1.000 20.93562 ? 140 ALA A N   1 
ATOM   1039 C CA  . ALA A 1 140 ? 11.76560  17.85171 -4.19460  1.000 21.17373 ? 140 ALA A CA  1 
ATOM   1040 C C   . ALA A 1 140 ? 12.56636  17.83783 -5.48475  1.000 26.82397 ? 140 ALA A C   1 
ATOM   1041 O O   . ALA A 1 140 ? 12.21786  18.57266 -6.40690  1.000 24.70799 ? 140 ALA A O   1 
ATOM   1042 C CB  . ALA A 1 140 ? 10.39897  17.20686 -4.43735  1.000 27.92026 ? 140 ALA A CB  1 
ATOM   1043 N N   . PRO A 1 141 ? 13.61413  17.01555 -5.58978  1.000 30.23031 ? 141 PRO A N   1 
ATOM   1044 C CA  . PRO A 1 141 ? 14.44015  17.03092 -6.81739  1.000 35.19885 ? 141 PRO A CA  1 
ATOM   1045 C C   . PRO A 1 141 ? 13.63933  16.75082 -8.07826  1.000 41.85882 ? 141 PRO A C   1 
ATOM   1046 O O   . PRO A 1 141 ? 13.80143  17.45664 -9.08948  1.000 45.74405 ? 141 PRO A O   1 
ATOM   1047 C CB  . PRO A 1 141 ? 15.47762  15.93922 -6.53434  1.000 31.74974 ? 141 PRO A CB  1 
ATOM   1048 C CG  . PRO A 1 141 ? 15.62032  15.94454 -5.01941  1.000 31.76957 ? 141 PRO A CG  1 
ATOM   1049 C CD  . PRO A 1 141 ? 14.17387  16.13926 -4.54285  1.000 32.66277 ? 141 PRO A CD  1 
ATOM   1050 N N   . GLY A 1 142 ? 12.72274  15.77986 -8.01991  1.000 36.58220 ? 142 GLY A N   1 
ATOM   1051 C CA  . GLY A 1 142 ? 11.87122  15.45522 -9.15053  1.000 34.14202 ? 142 GLY A CA  1 
ATOM   1052 C C   . GLY A 1 142 ? 10.91389  16.55480 -9.55803  1.000 44.46214 ? 142 GLY A C   1 
ATOM   1053 O O   . GLY A 1 142 ? 10.29669  16.45453 -10.62122 1.000 41.49088 ? 142 GLY A O   1 
ATOM   1054 N N   . GLY A 1 143 ? 10.77892  17.60109 -8.75578  1.000 34.26842 ? 143 GLY A N   1 
ATOM   1055 C CA  . GLY A 1 143 ? 9.81046   18.63773 -9.04953  1.000 26.95134 ? 143 GLY A CA  1 
ATOM   1056 C C   . GLY A 1 143 ? 8.85100   18.72257 -7.86607  1.000 23.66227 ? 143 GLY A C   1 
ATOM   1057 O O   . GLY A 1 143 ? 8.68020   17.74569 -7.12331  1.000 30.58171 ? 143 GLY A O   1 
ATOM   1058 N N   . GLY A 1 144 ? 8.28154   19.87350 -7.60394  1.000 21.71377 ? 144 GLY A N   1 
ATOM   1059 C CA  . GLY A 1 144 ? 7.30831   19.94154 -6.53120  1.000 18.63748 ? 144 GLY A CA  1 
ATOM   1060 C C   . GLY A 1 144 ? 7.91331   20.43100 -5.22698  1.000 19.66217 ? 144 GLY A C   1 
ATOM   1061 O O   . GLY A 1 144 ? 9.12212   20.64952 -5.09326  1.000 20.79440 ? 144 GLY A O   1 
ATOM   1062 N N   . CYS A 1 145 ? 7.03176   20.62466 -4.26459  1.000 15.65070 ? 145 CYS A N   1 
ATOM   1063 C CA  . CYS A 1 145 ? 7.39305   21.16456 -2.94181  1.000 14.50454 ? 145 CYS A CA  1 
ATOM   1064 C C   . CYS A 1 145 ? 6.79095   20.20035 -1.92233  1.000 16.85983 ? 145 CYS A C   1 
ATOM   1065 O O   . CYS A 1 145 ? 5.56568   20.10589 -1.78629  1.000 14.33627 ? 145 CYS A O   1 
ATOM   1066 C CB  . CYS A 1 145 ? 6.85581   22.59101 -2.76621  1.000 17.58593 ? 145 CYS A CB  1 
ATOM   1067 S SG  . CYS A 1 145 ? 7.41248   23.38214 -1.26440  1.000 15.91210 ? 145 CYS A SG  1 
ATOM   1068 N N   . ASN A 1 146 ? 7.64441   19.46022 -1.23198  1.000 14.88805 ? 146 ASN A N   1 
ATOM   1069 C CA  . ASN A 1 146 ? 7.13421   18.46384 -0.27666  1.000 16.68509 ? 146 ASN A CA  1 
ATOM   1070 C C   . ASN A 1 146 ? 6.54377   19.12594 0.95360   1.000 16.26181 ? 146 ASN A C   1 
ATOM   1071 O O   . ASN A 1 146 ? 6.98405   20.19233 1.36561   1.000 15.56936 ? 146 ASN A O   1 
ATOM   1072 C CB  . ASN A 1 146 ? 8.26703   17.58951 0.24891   1.000 14.13487 ? 146 ASN A CB  1 
ATOM   1073 C CG  . ASN A 1 146 ? 8.73521   16.56117 -0.72752  1.000 23.30337 ? 146 ASN A CG  1 
ATOM   1074 O OD1 . ASN A 1 146 ? 7.94025   15.83004 -1.27913  1.000 23.09727 ? 146 ASN A OD1 1 
ATOM   1075 N ND2 . ASN A 1 146 ? 10.07045  16.47017 -0.91039  1.000 25.81769 ? 146 ASN A ND2 1 
ATOM   1076 N N   . ASP A 1 147 ? 5.60376   18.41676 1.61287   1.000 13.95812 ? 147 ASP A N   1 
ATOM   1077 C CA  . ASP A 1 147 ? 5.22936   18.81197 2.97073   1.000 14.96106 ? 147 ASP A CA  1 
ATOM   1078 C C   . ASP A 1 147 ? 6.31263   18.37790 3.96911   1.000 14.83930 ? 147 ASP A C   1 
ATOM   1079 O O   . ASP A 1 147 ? 7.12616   17.47368 3.71150   1.000 14.93792 ? 147 ASP A O   1 
ATOM   1080 C CB  . ASP A 1 147 ? 3.91997   18.13901 3.35191   1.000 15.65637 ? 147 ASP A CB  1 
ATOM   1081 C CG  . ASP A 1 147 ? 4.06672   16.64765 3.39239   1.000 17.59454 ? 147 ASP A CG  1 
ATOM   1082 O OD1 . ASP A 1 147 ? 4.13224   16.00158 2.32428   1.000 15.06217 ? 147 ASP A OD1 1 
ATOM   1083 O OD2 . ASP A 1 147 ? 4.14525   16.10786 4.52181   1.000 17.26346 ? 147 ASP A OD2 1 
ATOM   1084 N N   . ALA A 1 148 ? 6.27587   18.99650 5.16165   1.000 14.04086 ? 148 ALA A N   1 
ATOM   1085 C CA  . ALA A 1 148 ? 7.30336   18.71387 6.15681   1.000 15.12134 ? 148 ALA A CA  1 
ATOM   1086 C C   . ALA A 1 148 ? 7.17568   17.33419 6.77759   1.000 14.14163 ? 148 ALA A C   1 
ATOM   1087 O O   . ALA A 1 148 ? 8.17207   16.81107 7.30136   1.000 16.55168 ? 148 ALA A O   1 
ATOM   1088 C CB  . ALA A 1 148 ? 7.22265   19.77820 7.27537   1.000 15.04942 ? 148 ALA A CB  1 
ATOM   1089 N N   . CYS A 1 149 ? 5.96869   16.75922 6.83106   1.000 14.85796 ? 149 CYS A N   1 
ATOM   1090 C CA  . CYS A 1 149 ? 5.85253   15.40644 7.38307   1.000 12.86117 ? 149 CYS A CA  1 
ATOM   1091 C C   . CYS A 1 149 ? 6.58325   14.41085 6.47508   1.000 19.64307 ? 149 CYS A C   1 
ATOM   1092 O O   . CYS A 1 149 ? 7.36750   13.56924 6.93633   1.000 17.59079 ? 149 CYS A O   1 
ATOM   1093 C CB  . CYS A 1 149 ? 4.37353   15.03975 7.54849   1.000 17.37035 ? 149 CYS A CB  1 
ATOM   1094 S SG  . CYS A 1 149 ? 4.08822   13.26988 7.89328   1.000 17.67144 ? 149 CYS A SG  1 
ATOM   1095 N N   . THR A 1 150 ? 6.35026   14.50012 5.16339   1.000 14.29966 ? 150 THR A N   1 
ATOM   1096 C CA  . THR A 1 150 ? 7.09854   13.64507 4.22033   1.000 13.08410 ? 150 THR A CA  1 
ATOM   1097 C C   . THR A 1 150 ? 8.59718   13.76958 4.39542   1.000 16.91231 ? 150 THR A C   1 
ATOM   1098 O O   . THR A 1 150 ? 9.31019   12.76793 4.36142   1.000 20.52886 ? 150 THR A O   1 
ATOM   1099 C CB  . THR A 1 150 ? 6.70975   14.02918 2.78788   1.000 18.88222 ? 150 THR A CB  1 
ATOM   1100 O OG1 . THR A 1 150 ? 5.31336   13.73310 2.63149   1.000 16.03384 ? 150 THR A OG1 1 
ATOM   1101 C CG2 . THR A 1 150 ? 7.54905   13.27948 1.74416   1.000 20.93623 ? 150 THR A CG2 1 
ATOM   1102 N N   . VAL A 1 151 ? 9.10362   14.99844 4.54188   1.000 16.38190 ? 151 VAL A N   1 
ATOM   1103 C CA  . VAL A 1 151 ? 10.54827  15.20613 4.59076   1.000 15.48381 ? 151 VAL A CA  1 
ATOM   1104 C C   . VAL A 1 151 ? 11.14739  14.73298 5.92371   1.000 19.29762 ? 151 VAL A C   1 
ATOM   1105 O O   . VAL A 1 151 ? 12.15979  14.01882 5.95630   1.000 18.15306 ? 151 VAL A O   1 
ATOM   1106 C CB  . VAL A 1 151 ? 10.86517  16.69239 4.32456   1.000 16.49973 ? 151 VAL A CB  1 
ATOM   1107 C CG1 . VAL A 1 151 ? 12.36265  16.96366 4.52096   1.000 17.24291 ? 151 VAL A CG1 1 
ATOM   1108 C CG2 . VAL A 1 151 ? 10.43292  17.03691 2.88057   1.000 16.16836 ? 151 VAL A CG2 1 
ATOM   1109 N N   . PHE A 1 152 ? 10.56836  15.15002 7.04373   1.000 17.44489 ? 152 PHE A N   1 
ATOM   1110 C CA  . PHE A 1 152 ? 11.23560  14.99707 8.34540   1.000 16.16454 ? 152 PHE A CA  1 
ATOM   1111 C C   . PHE A 1 152 ? 10.66747  13.90558 9.24222   1.000 17.20333 ? 152 PHE A C   1 
ATOM   1112 O O   . PHE A 1 152 ? 11.35937  13.49546 10.18625  1.000 19.21057 ? 152 PHE A O   1 
ATOM   1113 C CB  . PHE A 1 152 ? 11.18313  16.33418 9.12615   1.000 13.40706 ? 152 PHE A CB  1 
ATOM   1114 C CG  . PHE A 1 152 ? 11.97542  17.41026 8.47298   1.000 14.45076 ? 152 PHE A CG  1 
ATOM   1115 C CD1 . PHE A 1 152 ? 13.37703  17.39768 8.52730   1.000 18.73561 ? 152 PHE A CD1 1 
ATOM   1116 C CD2 . PHE A 1 152 ? 11.33288  18.44477 7.79053   1.000 19.43956 ? 152 PHE A CD2 1 
ATOM   1117 C CE1 . PHE A 1 152 ? 14.11895  18.41649 7.93901   1.000 22.44285 ? 152 PHE A CE1 1 
ATOM   1118 C CE2 . PHE A 1 152 ? 12.06706  19.45693 7.19357   1.000 20.14169 ? 152 PHE A CE2 1 
ATOM   1119 C CZ  . PHE A 1 152 ? 13.46436  19.43626 7.24303   1.000 19.04800 ? 152 PHE A CZ  1 
ATOM   1120 N N   . GLN A 1 153 ? 9.42643   13.44013 9.00776   1.000 17.51078 ? 153 GLN A N   1 
ATOM   1121 C CA  . GLN A 1 153 ? 8.86067   12.28113 9.71615   1.000 13.59599 ? 153 GLN A CA  1 
ATOM   1122 C C   . GLN A 1 153 ? 8.89516   12.45172 11.23857  1.000 17.38136 ? 153 GLN A C   1 
ATOM   1123 O O   . GLN A 1 153 ? 9.35057   11.55495 11.97521  1.000 18.61473 ? 153 GLN A O   1 
ATOM   1124 C CB  . GLN A 1 153 ? 9.60596   10.98842 9.30620   1.000 13.74888 ? 153 GLN A CB  1 
ATOM   1125 C CG  . GLN A 1 153 ? 9.49313   10.59405 7.78074   1.000 22.88610 ? 153 GLN A CG  1 
ATOM   1126 C CD  . GLN A 1 153 ? 8.18333   9.90589  7.48938   1.000 33.60693 ? 153 GLN A CD  1 
ATOM   1127 O OE1 . GLN A 1 153 ? 8.07152   8.69159  7.66462   1.000 32.29140 ? 153 GLN A OE1 1 
ATOM   1128 N NE2 . GLN A 1 153 ? 7.17159   10.66655 7.04109   1.000 31.08109 ? 153 GLN A NE2 1 
ATOM   1129 N N   . THR A 1 154 ? 8.43972   13.61050 11.73084  1.000 15.90088 ? 154 THR A N   1 
ATOM   1130 C CA  . THR A 1 154 ? 8.32228   13.84051 13.17639  1.000 14.80461 ? 154 THR A CA  1 
ATOM   1131 C C   . THR A 1 154 ? 6.85549   13.80009 13.59537  1.000 16.35073 ? 154 THR A C   1 
ATOM   1132 O O   . THR A 1 154 ? 5.96869   14.05002 12.78753  1.000 15.73556 ? 154 THR A O   1 
ATOM   1133 C CB  . THR A 1 154 ? 8.89958   15.20478 13.60943  1.000 16.75440 ? 154 THR A CB  1 
ATOM   1134 O OG1 . THR A 1 154 ? 8.10708   16.25751 13.04529  1.000 17.93207 ? 154 THR A OG1 1 
ATOM   1135 C CG2 . THR A 1 154 ? 10.34313  15.39936 13.13909  1.000 20.10786 ? 154 THR A CG2 1 
ATOM   1136 N N   . SER A 1 155 ? 6.61192   13.51926 14.88614  1.000 13.33387 ? 155 SER A N   1 
ATOM   1137 C CA  . SER A 1 155 ? 5.23635   13.54593 15.39045  1.000 13.82052 ? 155 SER A CA  1 
ATOM   1138 C C   . SER A 1 155 ? 4.59970   14.91075 15.19582  1.000 17.55813 ? 155 SER A C   1 
ATOM   1139 O O   . SER A 1 155 ? 3.39162   15.00468 14.97478  1.000 18.97886 ? 155 SER A O   1 
ATOM   1140 C CB  . SER A 1 155 ? 5.19976   13.19751 16.87639  1.000 20.75826 ? 155 SER A CB  1 
ATOM   1141 O OG  . SER A 1 155 ? 5.76095   11.93316 17.02859  1.000 28.47294 ? 155 SER A OG  1 
ATOM   1142 N N   . GLU A 1 156 ? 5.39001   15.97212 15.29842  1.000 15.21003 ? 156 GLU A N   1 
ATOM   1143 C CA  . GLU A 1 156 ? 4.82684   17.31449 15.18061  1.000 12.53632 ? 156 GLU A CA  1 
ATOM   1144 C C   . GLU A 1 156 ? 4.35218   17.60322 13.75744  1.000 17.03661 ? 156 GLU A C   1 
ATOM   1145 O O   . GLU A 1 156 ? 3.25914   18.13416 13.56884  1.000 17.21239 ? 156 GLU A O   1 
ATOM   1146 C CB  . GLU A 1 156 ? 5.86910   18.35303 15.60401  1.000 13.77689 ? 156 GLU A CB  1 
ATOM   1147 C CG  . GLU A 1 156 ? 5.25027   19.75673 15.80913  1.000 16.20828 ? 156 GLU A CG  1 
ATOM   1148 C CD  . GLU A 1 156 ? 4.12656   19.81546 16.87479  1.000 20.21353 ? 156 GLU A CD  1 
ATOM   1149 O OE1 . GLU A 1 156 ? 3.98814   18.90082 17.72662  1.000 19.02812 ? 156 GLU A OE1 1 
ATOM   1150 O OE2 . GLU A 1 156 ? 3.34728   20.80089 16.85994  1.000 20.53023 ? 156 GLU A OE2 1 
ATOM   1151 N N   . TYR A 1 157 ? 5.17156   17.29941 12.74719  1.000 14.52742 ? 157 TYR A N   1 
ATOM   1152 C CA  . TYR A 1 157 ? 4.74362   17.62158 11.38104  1.000 13.38601 ? 157 TYR A CA  1 
ATOM   1153 C C   . TYR A 1 157 ? 3.65222   16.67788 10.89820  1.000 16.71035 ? 157 TYR A C   1 
ATOM   1154 O O   . TYR A 1 157 ? 2.79001   17.07721 10.10030  1.000 17.15965 ? 157 TYR A O   1 
ATOM   1155 C CB  . TYR A 1 157 ? 5.92302   17.51821 10.39924  1.000 14.74041 ? 157 TYR A CB  1 
ATOM   1156 C CG  . TYR A 1 157 ? 6.98851   18.55291 10.64485  1.000 16.05415 ? 157 TYR A CG  1 
ATOM   1157 C CD1 . TYR A 1 157 ? 6.65830   19.88010 10.91530  1.000 17.71034 ? 157 TYR A CD1 1 
ATOM   1158 C CD2 . TYR A 1 157 ? 8.30995   18.19124 10.60069  1.000 12.44995 ? 157 TYR A CD2 1 
ATOM   1159 C CE1 . TYR A 1 157 ? 7.64748   20.81244 11.12342  1.000 16.15849 ? 157 TYR A CE1 1 
ATOM   1160 C CE2 . TYR A 1 157 ? 9.33100   19.12498 10.81281  1.000 14.48003 ? 157 TYR A CE2 1 
ATOM   1161 C CZ  . TYR A 1 157 ? 8.98058   20.42481 11.08652  1.000 16.00974 ? 157 TYR A CZ  1 
ATOM   1162 O OH  . TYR A 1 157 ? 9.97871   21.34978 11.33243  1.000 16.69770 ? 157 TYR A OH  1 
ATOM   1163 N N   . CYS A 1 158 ? 3.69817   15.42373 11.33501  1.000 17.26148 ? 158 CYS A N   1 
ATOM   1164 C CA  . CYS A 1 158 ? 2.75176   14.40382 10.89151  1.000 18.69439 ? 158 CYS A CA  1 
ATOM   1165 C C   . CYS A 1 158 ? 1.51395   14.33123 11.77927  1.000 18.72135 ? 158 CYS A C   1 
ATOM   1166 O O   . CYS A 1 158 ? 0.52830   13.68813 11.38568  1.000 18.68646 ? 158 CYS A O   1 
ATOM   1167 C CB  . CYS A 1 158 ? 3.43627   13.02510 10.84394  1.000 15.50511 ? 158 CYS A CB  1 
ATOM   1168 S SG  . CYS A 1 158 ? 4.89423   13.00118 9.75029   1.000 17.14416 ? 158 CYS A SG  1 
ATOM   1169 N N   . CYS A 1 159 ? 1.53716   15.01741 12.92448  1.000 16.86808 ? 159 CYS A N   1 
ATOM   1170 C CA  A CYS A 1 159 ? 0.40114   15.11699 13.83546  0.587 20.45602 ? 159 CYS A CA  1 
ATOM   1171 C CA  B CYS A 1 159 ? 0.39160   15.11748 13.82960  0.413 20.43995 ? 159 CYS A CA  1 
ATOM   1172 C C   . CYS A 1 159 ? 0.00283   13.73893 14.34767  1.000 20.85226 ? 159 CYS A C   1 
ATOM   1173 O O   . CYS A 1 159 ? -1.17455  13.42946 14.53026  1.000 21.04471 ? 159 CYS A O   1 
ATOM   1174 C CB  A CYS A 1 159 ? -0.78177  15.81917 13.17684  0.587 17.90464 ? 159 CYS A CB  1 
ATOM   1175 C CB  B CYS A 1 159 ? -0.79516  15.81144 13.15450  0.413 17.88127 ? 159 CYS A CB  1 
ATOM   1176 S SG  A CYS A 1 159 ? -1.68624  16.75358 14.39993  0.587 20.21714 ? 159 CYS A SG  1 
ATOM   1177 S SG  B CYS A 1 159 ? -0.45641  17.53176 12.71519  0.413 20.19039 ? 159 CYS A SG  1 
ATOM   1178 N N   . THR A 1 160 ? 1.01720   12.92205 14.60219  1.000 20.14704 ? 160 THR A N   1 
ATOM   1179 C CA  . THR A 1 160 ? 0.84189   11.51697 14.93984  1.000 19.44183 ? 160 THR A CA  1 
ATOM   1180 C C   . THR A 1 160 ? 0.05355   11.31989 16.23112  1.000 24.30760 ? 160 THR A C   1 
ATOM   1181 O O   . THR A 1 160 ? -0.70171  10.34688 16.35168  1.000 34.03263 ? 160 THR A O   1 
ATOM   1182 C CB  . THR A 1 160 ? 2.23719   10.91197 15.08959  1.000 23.38412 ? 160 THR A CB  1 
ATOM   1183 O OG1 . THR A 1 160 ? 2.95089   11.20104 13.88861  1.000 27.86843 ? 160 THR A OG1 1 
ATOM   1184 C CG2 . THR A 1 160 ? 2.14010   9.40907  15.24457  1.000 35.20548 ? 160 THR A CG2 1 
ATOM   1185 N N   . THR A 1 161 ? 0.22238   12.21542 17.19729  1.000 24.96454 ? 161 THR A N   1 
ATOM   1186 C CA  . THR A 1 161 ? -0.44856  12.04675 18.47809  1.000 33.70811 ? 161 THR A CA  1 
ATOM   1187 C C   . THR A 1 161 ? -1.83413  12.66244 18.46722  1.000 41.44545 ? 161 THR A C   1 
ATOM   1188 O O   . THR A 1 161 ? -2.54063  12.54752 19.46107  1.000 42.43845 ? 161 THR A O   1 
ATOM   1189 C CB  . THR A 1 161 ? 0.38012   12.66240 19.60437  1.000 32.62815 ? 161 THR A CB  1 
ATOM   1190 O OG1 . THR A 1 161 ? 0.23776   14.07958 19.56268  1.000 35.64207 ? 161 THR A OG1 1 
ATOM   1191 C CG2 . THR A 1 161 ? 1.89779   12.32868 19.47755  1.000 32.29923 ? 161 THR A CG2 1 
ATOM   1192 N N   . GLY A 1 162 ? -2.24576  13.29851 17.36658  1.000 32.33200 ? 162 GLY A N   1 
ATOM   1193 C CA  . GLY A 1 162 ? -3.48731  14.03669 17.33505  1.000 34.27553 ? 162 GLY A CA  1 
ATOM   1194 C C   . GLY A 1 162 ? -3.39264  15.40795 17.95745  1.000 29.67929 ? 162 GLY A C   1 
ATOM   1195 O O   . GLY A 1 162 ? -4.37854  16.15965 17.94301  1.000 33.80815 ? 162 GLY A O   1 
ATOM   1196 N N   . LYS A 1 163 ? -2.24794  15.76255 18.51413  1.000 28.31138 ? 163 LYS A N   1 
ATOM   1197 C CA  . LYS A 1 163 ? -1.98626  17.11767 18.95586  1.000 29.30390 ? 163 LYS A CA  1 
ATOM   1198 C C   . LYS A 1 163 ? -0.78753  17.59766 18.16042  1.000 37.51234 ? 163 LYS A C   1 
ATOM   1199 O O   . LYS A 1 163 ? 0.24410   16.92160 18.09519  1.000 35.76897 ? 163 LYS A O   1 
ATOM   1200 C CB  . LYS A 1 163 ? -1.70959  17.19989 20.45549  1.000 34.37640 ? 163 LYS A CB  1 
ATOM   1201 N N   . CYS A 1 164 ? -0.93674  18.74102 17.52588  1.000 24.75027 ? 164 CYS A N   1 
ATOM   1202 C CA  . CYS A 1 164 ? 0.18999   19.35079 16.82166  1.000 18.46177 ? 164 CYS A CA  1 
ATOM   1203 C C   . CYS A 1 164 ? -0.26321  20.77069 16.54597  1.000 24.71248 ? 164 CYS A C   1 
ATOM   1204 O O   . CYS A 1 164 ? -1.47013  21.05956 16.54894  1.000 23.97926 ? 164 CYS A O   1 
ATOM   1205 C CB  . CYS A 1 164 ? 0.54105   18.62837 15.49698  1.000 18.30165 ? 164 CYS A CB  1 
ATOM   1206 S SG  . CYS A 1 164 ? -0.89027  18.61268 14.33717  1.000 22.96922 ? 164 CYS A SG  1 
ATOM   1207 N N   . GLY A 1 165 ? 0.70001   21.64788 16.28251  1.000 17.65696 ? 165 GLY A N   1 
ATOM   1208 C CA  . GLY A 1 165 ? 0.35991   23.01489 15.95236  1.000 17.40895 ? 165 GLY A CA  1 
ATOM   1209 C C   . GLY A 1 165 ? 0.86492   23.33506 14.55682  1.000 16.57046 ? 165 GLY A C   1 
ATOM   1210 O O   . GLY A 1 165 ? 1.54953   22.53598 13.91741  1.000 19.13083 ? 165 GLY A O   1 
ATOM   1211 N N   . PRO A 1 166 ? 0.54690   24.52728 14.06944  1.000 16.67928 ? 166 PRO A N   1 
ATOM   1212 C CA  . PRO A 1 166 ? 1.15358   24.99757 12.82327  1.000 16.34653 ? 166 PRO A CA  1 
ATOM   1213 C C   . PRO A 1 166 ? 2.65540   25.13318 13.02964  1.000 20.65927 ? 166 PRO A C   1 
ATOM   1214 O O   . PRO A 1 166 ? 3.13381   25.28284 14.15260  1.000 18.98552 ? 166 PRO A O   1 
ATOM   1215 C CB  . PRO A 1 166 ? 0.48236   26.36003 12.57671  1.000 17.66728 ? 166 PRO A CB  1 
ATOM   1216 C CG  . PRO A 1 166 ? -0.16090  26.75326 13.91511  1.000 21.57423 ? 166 PRO A CG  1 
ATOM   1217 C CD  . PRO A 1 166 ? -0.24095  25.53715 14.79681  1.000 18.02788 ? 166 PRO A CD  1 
ATOM   1218 N N   . THR A 1 167 ? 3.39911   25.13410 11.92970  1.000 16.51361 ? 167 THR A N   1 
ATOM   1219 C CA  . THR A 1 167 ? 4.85788   25.14841 11.96608  1.000 15.50776 ? 167 THR A CA  1 
ATOM   1220 C C   . THR A 1 167 ? 5.34538   26.15238 10.93627  1.000 17.69797 ? 167 THR A C   1 
ATOM   1221 O O   . THR A 1 167 ? 4.57080   26.65335 10.11843  1.000 18.71916 ? 167 THR A O   1 
ATOM   1222 C CB  . THR A 1 167 ? 5.43683   23.76096 11.63837  1.000 17.04706 ? 167 THR A CB  1 
ATOM   1223 O OG1 . THR A 1 167 ? 5.07943   23.46441 10.27769  1.000 16.41788 ? 167 THR A OG1 1 
ATOM   1224 C CG2 . THR A 1 167 ? 4.79277   22.68756 12.55834  1.000 13.80017 ? 167 THR A CG2 1 
ATOM   1225 N N   . GLU A 1 168 ? 6.65218   26.43046 10.94336  1.000 14.25108 ? 168 GLU A N   1 
ATOM   1226 C CA  A GLU A 1 168 ? 7.18162   27.33722 9.93281   0.598 17.26486 ? 168 GLU A CA  1 
ATOM   1227 C CA  B GLU A 1 168 ? 7.19182   27.32988 9.92997   0.402 17.35731 ? 168 GLU A CA  1 
ATOM   1228 C C   . GLU A 1 168 ? 6.86276   26.82442 8.53215   1.000 19.15532 ? 168 GLU A C   1 
ATOM   1229 O O   . GLU A 1 168 ? 6.56821   27.61440 7.62646   1.000 18.33527 ? 168 GLU A O   1 
ATOM   1230 C CB  A GLU A 1 168 ? 8.68712   27.52295 10.10338  0.598 21.41765 ? 168 GLU A CB  1 
ATOM   1231 C CB  B GLU A 1 168 ? 8.70187   27.47645 10.08049  0.402 21.33174 ? 168 GLU A CB  1 
ATOM   1232 C CG  A GLU A 1 168 ? 9.05251   28.65204 11.08286  0.598 35.10288 ? 168 GLU A CG  1 
ATOM   1233 C CG  B GLU A 1 168 ? 9.25849   28.62021 9.24610   0.402 30.86577 ? 168 GLU A CG  1 
ATOM   1234 C CD  A GLU A 1 168 ? 8.29795   29.95766 10.80597  0.598 35.79577 ? 168 GLU A CD  1 
ATOM   1235 C CD  B GLU A 1 168 ? 10.68942  28.93663 9.57846   0.402 39.79999 ? 168 GLU A CD  1 
ATOM   1236 O OE1 A GLU A 1 168 ? 8.69125   30.67381 9.85898   0.598 45.29577 ? 168 GLU A OE1 1 
ATOM   1237 O OE1 B GLU A 1 168 ? 11.54976  28.84023 8.67891   0.402 49.97432 ? 168 GLU A OE1 1 
ATOM   1238 O OE2 A GLU A 1 168 ? 7.28842   30.24049 11.51223  0.598 35.73577 ? 168 GLU A OE2 1 
ATOM   1239 O OE2 B GLU A 1 168 ? 10.95416  29.27519 10.74947  0.402 41.25373 ? 168 GLU A OE2 1 
ATOM   1240 N N   . TYR A 1 169 ? 6.91231   25.49650 8.34376   1.000 15.77070 ? 169 TYR A N   1 
ATOM   1241 C CA  . TYR A 1 169 ? 6.65325   24.94579 7.01982   1.000 14.61980 ? 169 TYR A CA  1 
ATOM   1242 C C   . TYR A 1 169 ? 5.17544   25.00187 6.66623   1.000 15.79555 ? 169 TYR A C   1 
ATOM   1243 O O   . TYR A 1 169 ? 4.83090   25.36619 5.53963   1.000 17.23936 ? 169 TYR A O   1 
ATOM   1244 C CB  . TYR A 1 169 ? 7.18031   23.51657 6.93816   1.000 15.68986 ? 169 TYR A CB  1 
ATOM   1245 C CG  . TYR A 1 169 ? 8.69148   23.42978 7.10845   1.000 15.67805 ? 169 TYR A CG  1 
ATOM   1246 C CD1 . TYR A 1 169 ? 9.55263   24.10130 6.23592   1.000 17.36361 ? 169 TYR A CD1 1 
ATOM   1247 C CD2 . TYR A 1 169 ? 9.24830   22.67214 8.13745   1.000 14.81820 ? 169 TYR A CD2 1 
ATOM   1248 C CE1 . TYR A 1 169 ? 10.91530  24.02599 6.39051   1.000 17.43310 ? 169 TYR A CE1 1 
ATOM   1249 C CE2 . TYR A 1 169 ? 10.60475  22.56205 8.29090   1.000 16.15433 ? 169 TYR A CE2 1 
ATOM   1250 C CZ  . TYR A 1 169 ? 11.43910  23.24404 7.41469   1.000 18.56230 ? 169 TYR A CZ  1 
ATOM   1251 O OH  . TYR A 1 169 ? 12.81675  23.12967 7.60736   1.000 19.40665 ? 169 TYR A OH  1 
ATOM   1252 N N   . SER A 1 170 ? 4.26809   24.64817 7.60283   1.000 15.94088 ? 170 SER A N   1 
ATOM   1253 C CA  . SER A 1 170 ? 2.85386   24.71263 7.23991   1.000 17.33050 ? 170 SER A CA  1 
ATOM   1254 C C   . SER A 1 170 ? 2.43900   26.14572 6.94856   1.000 18.10294 ? 170 SER A C   1 
ATOM   1255 O O   . SER A 1 170 ? 1.62333   26.38732 6.03986   1.000 17.17484 ? 170 SER A O   1 
ATOM   1256 C CB  . SER A 1 170 ? 1.98812   24.09447 8.34868   1.000 14.94311 ? 170 SER A CB  1 
ATOM   1257 O OG  . SER A 1 170 ? 1.83990   24.94767 9.50148   1.000 17.29265 ? 170 SER A OG  1 
ATOM   1258 N N   . ARG A 1 171 ? 3.03898   27.12431 7.66071   1.000 14.92795 ? 171 ARG A N   1 
ATOM   1259 C CA  . ARG A 1 171 ? 2.61757   28.51909 7.44911   1.000 14.03912 ? 171 ARG A CA  1 
ATOM   1260 C C   . ARG A 1 171 ? 3.03119   29.01558 6.08876   1.000 15.82878 ? 171 ARG A C   1 
ATOM   1261 O O   . ARG A 1 171 ? 2.37851   29.92505 5.53968   1.000 18.47239 ? 171 ARG A O   1 
ATOM   1262 C CB  . ARG A 1 171 ? 3.21364   29.44810 8.53328   1.000 15.95558 ? 171 ARG A CB  1 
ATOM   1263 C CG  . ARG A 1 171 ? 2.56587   29.26203 9.89088   1.000 20.00677 ? 171 ARG A CG  1 
ATOM   1264 C CD  . ARG A 1 171 ? 3.30674   30.23318 10.86869  1.000 19.25733 ? 171 ARG A CD  1 
ATOM   1265 N NE  . ARG A 1 171 ? 2.74260   30.04393 12.19119  1.000 26.12554 ? 171 ARG A NE  1 
ATOM   1266 C CZ  . ARG A 1 171 ? 3.31087   29.30506 13.13525  1.000 22.40323 ? 171 ARG A CZ  1 
ATOM   1267 N NH1 . ARG A 1 171 ? 4.52165   28.77516 12.96738  1.000 23.69618 ? 171 ARG A NH1 1 
ATOM   1268 N NH2 . ARG A 1 171 ? 2.67154   29.13755 14.29634  1.000 29.61768 ? 171 ARG A NH2 1 
ATOM   1269 N N   . PHE A 1 172 ? 4.07854   28.42239 5.50555   1.000 15.22544 ? 172 PHE A N   1 
ATOM   1270 C CA  . PHE A 1 172 ? 4.45761   28.76511 4.13883   1.000 14.61048 ? 172 PHE A CA  1 
ATOM   1271 C C   . PHE A 1 172 ? 3.34953   28.37021 3.16848   1.000 16.44208 ? 172 PHE A C   1 
ATOM   1272 O O   . PHE A 1 172 ? 2.91368   29.17718 2.33737   1.000 17.03845 ? 172 PHE A O   1 
ATOM   1273 C CB  . PHE A 1 172 ? 5.77987   28.06690 3.77538   1.000 16.19604 ? 172 PHE A CB  1 
ATOM   1274 C CG  . PHE A 1 172 ? 5.99098   27.94486 2.29211   1.000 17.20533 ? 172 PHE A CG  1 
ATOM   1275 C CD1 . PHE A 1 172 ? 6.36655   29.06394 1.56334   1.000 16.21634 ? 172 PHE A CD1 1 
ATOM   1276 C CD2 . PHE A 1 172 ? 5.75483   26.73159 1.62459   1.000 18.09951 ? 172 PHE A CD2 1 
ATOM   1277 C CE1 . PHE A 1 172 ? 6.51588   28.99582 0.15622   1.000 19.55347 ? 172 PHE A CE1 1 
ATOM   1278 C CE2 . PHE A 1 172 ? 5.90083   26.65004 0.22292   1.000 18.76454 ? 172 PHE A CE2 1 
ATOM   1279 C CZ  . PHE A 1 172 ? 6.27920   27.77979 -0.49854  1.000 18.26044 ? 172 PHE A CZ  1 
ATOM   1280 N N   . PHE A 1 173 ? 2.87442   27.11530 3.26370   1.000 16.55487 ? 173 PHE A N   1 
ATOM   1281 C CA  . PHE A 1 173 ? 1.79928   26.69613 2.37027   1.000 14.63882 ? 173 PHE A CA  1 
ATOM   1282 C C   . PHE A 1 173 ? 0.55564   27.54240 2.60014   1.000 16.28998 ? 173 PHE A C   1 
ATOM   1283 O O   . PHE A 1 173 ? -0.13711  27.90895 1.64656   1.000 18.45266 ? 173 PHE A O   1 
ATOM   1284 C CB  . PHE A 1 173 ? 1.49337   25.20167 2.57203   1.000 15.16309 ? 173 PHE A CB  1 
ATOM   1285 C CG  . PHE A 1 173 ? 2.55426   24.28414 2.01801   1.000 15.28379 ? 173 PHE A CG  1 
ATOM   1286 C CD1 . PHE A 1 173 ? 2.52698   23.89415 0.67886   1.000 14.09965 ? 173 PHE A CD1 1 
ATOM   1287 C CD2 . PHE A 1 173 ? 3.55961   23.78582 2.83552   1.000 16.44954 ? 173 PHE A CD2 1 
ATOM   1288 C CE1 . PHE A 1 173 ? 3.48671   23.05319 0.15889   1.000 19.51770 ? 173 PHE A CE1 1 
ATOM   1289 C CE2 . PHE A 1 173 ? 4.53947   22.95494 2.32627   1.000 17.08627 ? 173 PHE A CE2 1 
ATOM   1290 C CZ  . PHE A 1 173 ? 4.49458   22.57462 0.96115   1.000 18.68038 ? 173 PHE A CZ  1 
ATOM   1291 N N   . LYS A 1 174 ? 0.26874   27.85936 3.84884   1.000 15.26938 ? 174 LYS A N   1 
ATOM   1292 C CA  . LYS A 1 174 ? -0.94246  28.60832 4.18228   1.000 15.15649 ? 174 LYS A CA  1 
ATOM   1293 C C   . LYS A 1 174 ? -0.86099  30.06099 3.72246   1.000 15.29564 ? 174 LYS A C   1 
ATOM   1294 O O   . LYS A 1 174 ? -1.87432  30.63666 3.30909   1.000 18.86699 ? 174 LYS A O   1 
ATOM   1295 C CB  . LYS A 1 174 ? -1.19030  28.53739 5.70018   1.000 16.39068 ? 174 LYS A CB  1 
ATOM   1296 C CG  . LYS A 1 174 ? -2.59209  28.95512 6.11423   1.000 18.19211 ? 174 LYS A CG  1 
ATOM   1297 C CD  . LYS A 1 174 ? -3.60193  27.96884 5.52827   1.000 19.94253 ? 174 LYS A CD  1 
ATOM   1298 C CE  . LYS A 1 174 ? -4.98657  28.14720 6.19080   1.000 21.77181 ? 174 LYS A CE  1 
ATOM   1299 N NZ  . LYS A 1 174 ? -5.89860  27.00296 5.77391   1.000 21.57911 ? 174 LYS A NZ  1 
ATOM   1300 N N   . ARG A 1 175 ? 0.33267   30.65781 3.73925   1.000 14.90204 ? 175 ARG A N   1 
ATOM   1301 C CA  . ARG A 1 175 ? 0.45379   32.04044 3.29943   1.000 16.24029 ? 175 ARG A CA  1 
ATOM   1302 C C   . ARG A 1 175 ? 0.17738   32.15643 1.80385   1.000 24.64266 ? 175 ARG A C   1 
ATOM   1303 O O   . ARG A 1 175 ? -0.50485  33.08564 1.37603   1.000 21.86495 ? 175 ARG A O   1 
ATOM   1304 C CB  . ARG A 1 175 ? 1.85913   32.53620 3.62961   1.000 22.06891 ? 175 ARG A CB  1 
ATOM   1305 C CG  . ARG A 1 175 ? 2.19569   33.85119 3.01221   1.000 25.85279 ? 175 ARG A CG  1 
ATOM   1306 C CD  . ARG A 1 175 ? 3.53242   34.39707 3.60387   1.000 25.14011 ? 175 ARG A CD  1 
ATOM   1307 N NE  . ARG A 1 175 ? 4.71791   33.63857 3.17955   1.000 30.65212 ? 175 ARG A NE  1 
ATOM   1308 C CZ  . ARG A 1 175 ? 5.37373   33.80918 2.02511   1.000 35.11211 ? 175 ARG A CZ  1 
ATOM   1309 N NH1 . ARG A 1 175 ? 4.93993   34.64584 1.08944   1.000 35.63332 ? 175 ARG A NH1 1 
ATOM   1310 N NH2 . ARG A 1 175 ? 6.50885   33.13863 1.81374   1.000 32.48740 ? 175 ARG A NH2 1 
ATOM   1311 N N   . LEU A 1 176 ? 0.67360   31.19283 1.01548   1.000 18.30610 ? 176 LEU A N   1 
ATOM   1312 C CA  . LEU A 1 176 ? 0.47130   31.20336 -0.43154  1.000 18.63825 ? 176 LEU A CA  1 
ATOM   1313 C C   . LEU A 1 176 ? -0.92848  30.70873 -0.83482  1.000 21.18993 ? 176 LEU A C   1 
ATOM   1314 O O   . LEU A 1 176 ? -1.48833  31.18208 -1.85068  1.000 20.44849 ? 176 LEU A O   1 
ATOM   1315 C CB  . LEU A 1 176 ? 1.56917   30.37037 -1.10929  1.000 18.97214 ? 176 LEU A CB  1 
ATOM   1316 C CG  . LEU A 1 176 ? 2.94588   31.05853 -1.10567  1.000 31.40328 ? 176 LEU A CG  1 
ATOM   1317 C CD1 . LEU A 1 176 ? 3.82958   30.46451 -2.16310  1.000 27.85447 ? 176 LEU A CD1 1 
ATOM   1318 C CD2 . LEU A 1 176 ? 2.79041   32.50975 -1.34771  1.000 43.24245 ? 176 LEU A CD2 1 
ATOM   1319 N N   . CYS A 1 177 ? -1.50953  29.76846 -0.08957  1.000 16.62102 ? 177 CYS A N   1 
ATOM   1320 C CA  . CYS A 1 177 ? -2.81517  29.18721 -0.44140  1.000 18.24702 ? 177 CYS A CA  1 
ATOM   1321 C C   . CYS A 1 177 ? -3.66396  29.06811 0.80944   1.000 17.80391 ? 177 CYS A C   1 
ATOM   1322 O O   . CYS A 1 177 ? -3.73903  27.99688 1.44731   1.000 18.32188 ? 177 CYS A O   1 
ATOM   1323 C CB  . CYS A 1 177 ? -2.65910  27.81337 -1.10657  1.000 20.24164 ? 177 CYS A CB  1 
ATOM   1324 S SG  . CYS A 1 177 ? -2.17163  28.00743 -2.82022  1.000 18.62056 ? 177 CYS A SG  1 
ATOM   1325 N N   . PRO A 1 178 ? -4.30093  30.16135 1.21461   1.000 18.54429 ? 178 PRO A N   1 
ATOM   1326 C CA  . PRO A 1 178 ? -5.08998  30.14551 2.44490   1.000 20.57775 ? 178 PRO A CA  1 
ATOM   1327 C C   . PRO A 1 178 ? -6.28176  29.20224 2.39290   1.000 19.55774 ? 178 PRO A C   1 
ATOM   1328 O O   . PRO A 1 178 ? -6.76723  28.77302 3.45019   1.000 20.71054 ? 178 PRO A O   1 
ATOM   1329 C CB  . PRO A 1 178 ? -5.56972  31.59874 2.56947   1.000 24.68305 ? 178 PRO A CB  1 
ATOM   1330 C CG  . PRO A 1 178 ? -4.66239  32.39928 1.68155   1.000 28.62937 ? 178 PRO A CG  1 
ATOM   1331 C CD  . PRO A 1 178 ? -4.21807  31.51843 0.60308   1.000 23.98178 ? 178 PRO A CD  1 
ATOM   1332 N N   . ASP A 1 179 ? -6.78984  28.88989 1.19983   1.000 18.26931 ? 179 ASP A N   1 
ATOM   1333 C CA  . ASP A 1 179 ? -7.98952  28.06736 1.10329   1.000 21.48961 ? 179 ASP A CA  1 
ATOM   1334 C C   . ASP A 1 179 ? -7.70128  26.58915 0.97274   1.000 25.23485 ? 179 ASP A C   1 
ATOM   1335 O O   . ASP A 1 179 ? -8.60270  25.83701 0.62367   1.000 26.85955 ? 179 ASP A O   1 
ATOM   1336 C CB  . ASP A 1 179 ? -8.83252  28.49636 -0.08940  1.000 26.92882 ? 179 ASP A CB  1 
ATOM   1337 C CG  . ASP A 1 179 ? -9.51610  29.80955 0.15369   1.000 39.92112 ? 179 ASP A CG  1 
ATOM   1338 O OD1 . ASP A 1 179 ? -9.76278  30.16714 1.35409   1.000 44.36508 ? 179 ASP A OD1 1 
ATOM   1339 O OD2 . ASP A 1 179 ? -9.79548  30.48966 -0.84733  1.000 44.76593 ? 179 ASP A OD2 1 
ATOM   1340 N N   . ALA A 1 180 ? -6.47657  26.15860 1.22669   1.000 19.31472 ? 180 ALA A N   1 
ATOM   1341 C CA  . ALA A 1 180 ? -6.12625  24.75314 1.18946   1.000 13.71534 ? 180 ALA A CA  1 
ATOM   1342 C C   . ALA A 1 180 ? -5.63256  24.35461 2.57397   1.000 16.67502 ? 180 ALA A C   1 
ATOM   1343 O O   . ALA A 1 180 ? -4.99170  25.15858 3.25537   1.000 17.53919 ? 180 ALA A O   1 
ATOM   1344 C CB  . ALA A 1 180 ? -5.03676  24.48072 0.17457   1.000 16.57219 ? 180 ALA A CB  1 
ATOM   1345 N N   . PHE A 1 181 ? -5.87253  23.09516 2.96194   1.000 15.28040 ? 181 PHE A N   1 
ATOM   1346 C CA  . PHE A 1 181 ? -5.31170  22.58723 4.22009   1.000 16.65702 ? 181 PHE A CA  1 
ATOM   1347 C C   . PHE A 1 181 ? -3.79865  22.63379 4.19181   1.000 18.63115 ? 181 PHE A C   1 
ATOM   1348 O O   . PHE A 1 181 ? -3.18468  22.13535 3.24453   1.000 17.68623 ? 181 PHE A O   1 
ATOM   1349 C CB  . PHE A 1 181 ? -5.71861  21.13783 4.43097   1.000 15.98738 ? 181 PHE A CB  1 
ATOM   1350 C CG  . PHE A 1 181 ? -7.12133  20.96796 4.94406   1.000 17.20612 ? 181 PHE A CG  1 
ATOM   1351 C CD1 . PHE A 1 181 ? -8.19493  20.88648 4.05736   1.000 21.21394 ? 181 PHE A CD1 1 
ATOM   1352 C CD2 . PHE A 1 181 ? -7.35518  20.81454 6.31497   1.000 21.68089 ? 181 PHE A CD2 1 
ATOM   1353 C CE1 . PHE A 1 181 ? -9.49386  20.69374 4.53721   1.000 25.72878 ? 181 PHE A CE1 1 
ATOM   1354 C CE2 . PHE A 1 181 ? -8.64405  20.65055 6.79841   1.000 21.48132 ? 181 PHE A CE2 1 
ATOM   1355 C CZ  . PHE A 1 181 ? -9.71967  20.57823 5.92713   1.000 22.84351 ? 181 PHE A CZ  1 
ATOM   1356 N N   . SER A 1 182 ? -3.17979  23.13500 5.26839   1.000 14.27183 ? 182 SER A N   1 
ATOM   1357 C CA  . SER A 1 182 ? -1.70916  23.19169 5.29023   1.000 14.02763 ? 182 SER A CA  1 
ATOM   1358 C C   . SER A 1 182 ? -1.08375  22.21674 6.27242   1.000 17.85726 ? 182 SER A C   1 
ATOM   1359 O O   . SER A 1 182 ? 0.11607   21.93824 6.17295   1.000 18.62704 ? 182 SER A O   1 
ATOM   1360 C CB  . SER A 1 182 ? -1.24751  24.62601 5.60424   1.000 16.26483 ? 182 SER A CB  1 
ATOM   1361 O OG  . SER A 1 182 ? -1.65634  24.98859 6.93194   1.000 17.03550 ? 182 SER A OG  1 
ATOM   1362 N N   . TYR A 1 183 ? -1.85812  21.69036 7.20589   1.000 14.85061 ? 183 TYR A N   1 
ATOM   1363 C CA  . TYR A 1 183 ? -1.38449  20.64139 8.10487   1.000 17.35825 ? 183 TYR A CA  1 
ATOM   1364 C C   . TYR A 1 183 ? -2.63458  19.94335 8.62161   1.000 21.23994 ? 183 TYR A C   1 
ATOM   1365 O O   . TYR A 1 183 ? -3.75911  20.36668 8.34248   1.000 19.96863 ? 183 TYR A O   1 
ATOM   1366 C CB  . TYR A 1 183 ? -0.49014  21.21006 9.23213   1.000 16.52871 ? 183 TYR A CB  1 
ATOM   1367 C CG  . TYR A 1 183 ? -1.19504  22.01541 10.31333  1.000 18.59877 ? 183 TYR A CG  1 
ATOM   1368 C CD1 . TYR A 1 183 ? -1.65876  23.31776 10.06223  1.000 17.58666 ? 183 TYR A CD1 1 
ATOM   1369 C CD2 . TYR A 1 183 ? -1.37946  21.47261 11.61534  1.000 18.13815 ? 183 TYR A CD2 1 
ATOM   1370 C CE1 . TYR A 1 183 ? -2.30357  24.07036 11.06887  1.000 18.54272 ? 183 TYR A CE1 1 
ATOM   1371 C CE2 . TYR A 1 183 ? -2.01363  22.23864 12.63880  1.000 18.04217 ? 183 TYR A CE2 1 
ATOM   1372 C CZ  . TYR A 1 183 ? -2.48070  23.49770 12.33859  1.000 23.91195 ? 183 TYR A CZ  1 
ATOM   1373 O OH  . TYR A 1 183 ? -3.09894  24.21400 13.32145  1.000 23.80783 ? 183 TYR A OH  1 
ATOM   1374 N N   . VAL A 1 184 ? -2.42564  18.82794 9.32103   1.000 21.85508 ? 184 VAL A N   1 
ATOM   1375 C CA  . VAL A 1 184 ? -3.53373  17.91897 9.62763   1.000 23.25773 ? 184 VAL A CA  1 
ATOM   1376 C C   . VAL A 1 184 ? -4.62211  18.61794 10.43352  1.000 24.73071 ? 184 VAL A C   1 
ATOM   1377 O O   . VAL A 1 184 ? -5.81408  18.42459 10.16732  1.000 27.16084 ? 184 VAL A O   1 
ATOM   1378 C CB  . VAL A 1 184 ? -2.99893  16.66230 10.34510  1.000 27.00224 ? 184 VAL A CB  1 
ATOM   1379 C CG1 . VAL A 1 184 ? -4.14418  15.84047 10.89667  1.000 27.79390 ? 184 VAL A CG1 1 
ATOM   1380 C CG2 . VAL A 1 184 ? -2.18050  15.84485 9.39987   1.000 25.63118 ? 184 VAL A CG2 1 
ATOM   1381 N N   . LEU A 1 185 ? -4.26370  19.44740 11.41374  1.000 21.17722 ? 185 LEU A N   1 
ATOM   1382 C CA  . LEU A 1 185 ? -5.27562  20.06296 12.26619  1.000 20.03077 ? 185 LEU A CA  1 
ATOM   1383 C C   . LEU A 1 185 ? -5.56876  21.49625 11.88671  1.000 23.96323 ? 185 LEU A C   1 
ATOM   1384 O O   . LEU A 1 185 ? -6.01761  22.28741 12.72111  1.000 24.18601 ? 185 LEU A O   1 
ATOM   1385 C CB  . LEU A 1 185 ? -4.86262  19.98424 13.73921  1.000 22.24790 ? 185 LEU A CB  1 
ATOM   1386 C CG  . LEU A 1 185 ? -4.94020  18.63888 14.43015  1.000 29.63013 ? 185 LEU A CG  1 
ATOM   1387 C CD1 . LEU A 1 185 ? -4.43936  18.82653 15.87496  1.000 30.36383 ? 185 LEU A CD1 1 
ATOM   1388 C CD2 . LEU A 1 185 ? -6.36390  18.16767 14.36606  1.000 40.20449 ? 185 LEU A CD2 1 
ATOM   1389 N N   . ASP A 1 186 ? -5.33705  21.85736 10.63129  1.000 20.62096 ? 186 ASP A N   1 
ATOM   1390 C CA  . ASP A 1 186 ? -5.61611  23.21150 10.19028  1.000 17.42151 ? 186 ASP A CA  1 
ATOM   1391 C C   . ASP A 1 186 ? -7.10871  23.50957 10.33609  1.000 23.27930 ? 186 ASP A C   1 
ATOM   1392 O O   . ASP A 1 186 ? -7.94168  22.59841 10.27731  1.000 25.99591 ? 186 ASP A O   1 
ATOM   1393 C CB  . ASP A 1 186 ? -5.18768  23.31794 8.71889   1.000 17.65539 ? 186 ASP A CB  1 
ATOM   1394 C CG  . ASP A 1 186 ? -4.87347  24.72459 8.26821   1.000 21.33668 ? 186 ASP A CG  1 
ATOM   1395 O OD1 . ASP A 1 186 ? -5.09653  25.72524 8.98437   1.000 21.92873 ? 186 ASP A OD1 1 
ATOM   1396 O OD2 . ASP A 1 186 ? -4.39793  24.83971 7.12082   1.000 21.16963 ? 186 ASP A OD2 1 
ATOM   1397 N N   . LYS A 1 187 ? -7.43690  24.77721 10.58001  1.000 23.87447 ? 187 LYS A N   1 
ATOM   1398 C CA  . LYS A 1 187 ? -8.84701  25.17581 10.57563  1.000 25.34510 ? 187 LYS A CA  1 
ATOM   1399 C C   . LYS A 1 187 ? -9.44248  24.76473 9.22555   1.000 28.75518 ? 187 LYS A C   1 
ATOM   1400 O O   . LYS A 1 187 ? -8.87828  25.11402 8.17760   1.000 27.32242 ? 187 LYS A O   1 
ATOM   1401 C CB  . LYS A 1 187 ? -8.99667  26.68231 10.78618  1.000 27.16082 ? 187 LYS A CB  1 
ATOM   1402 N N   . PRO A 1 188 ? -10.52505 23.99065 9.19755   1.000 31.04257 ? 188 PRO A N   1 
ATOM   1403 C CA  . PRO A 1 188 ? -10.93304 23.37650 7.91870   1.000 29.78972 ? 188 PRO A CA  1 
ATOM   1404 C C   . PRO A 1 188 ? -11.34401 24.40155 6.87693   1.000 29.61840 ? 188 PRO A C   1 
ATOM   1405 O O   . PRO A 1 188 ? -11.95607 25.43526 7.15994   1.000 28.31641 ? 188 PRO A O   1 
ATOM   1406 C CB  . PRO A 1 188 ? -12.10122 22.44981 8.29952   1.000 26.29263 ? 188 PRO A CB  1 
ATOM   1407 C CG  . PRO A 1 188 ? -11.88868 22.19402 9.78996   1.000 34.83199 ? 188 PRO A CG  1 
ATOM   1408 C CD  . PRO A 1 188 ? -11.28077 23.46163 10.34321  1.000 35.75562 ? 188 PRO A CD  1 
ATOM   1409 N N   . THR A 1 189 ? -10.95768 24.11415 5.64117   1.000 24.10627 ? 189 THR A N   1 
ATOM   1410 C CA  . THR A 1 189 ? -11.39238 24.92594 4.50925   1.000 21.82904 ? 189 THR A CA  1 
ATOM   1411 C C   . THR A 1 189 ? -12.32816 24.13909 3.61396   1.000 24.53811 ? 189 THR A C   1 
ATOM   1412 O O   . THR A 1 189 ? -12.46993 24.45517 2.42686   1.000 27.23025 ? 189 THR A O   1 
ATOM   1413 C CB  . THR A 1 189 ? -10.17691 25.41897 3.73348   1.000 28.23136 ? 189 THR A CB  1 
ATOM   1414 O OG1 . THR A 1 189 ? -9.30176  24.30990 3.51936   1.000 26.97679 ? 189 THR A OG1 1 
ATOM   1415 C CG2 . THR A 1 189 ? -9.44036  26.50189 4.54629   1.000 29.21334 ? 189 THR A CG2 1 
ATOM   1416 N N   . THR A 1 190 ? -12.94073 23.10415 4.17488   1.000 23.32553 ? 190 THR A N   1 
ATOM   1417 C CA  . THR A 1 190 ? -13.91921 22.29744 3.45647   1.000 20.75992 ? 190 THR A CA  1 
ATOM   1418 C C   . THR A 1 190 ? -15.10205 23.16924 3.06201   1.000 24.97297 ? 190 THR A C   1 
ATOM   1419 O O   . THR A 1 190 ? -15.56523 23.99714 3.85608   1.000 27.48639 ? 190 THR A O   1 
ATOM   1420 C CB  . THR A 1 190 ? -14.34192 21.16074 4.36627   1.000 24.74377 ? 190 THR A CB  1 
ATOM   1421 O OG1 . THR A 1 190 ? -13.13632 20.51679 4.77858   1.000 30.27119 ? 190 THR A OG1 1 
ATOM   1422 C CG2 . THR A 1 190 ? -15.18402 20.14191 3.60341   1.000 22.85907 ? 190 THR A CG2 1 
ATOM   1423 N N   . VAL A 1 191 ? -15.58165 22.96511 1.83409   1.000 19.51623 ? 191 VAL A N   1 
ATOM   1424 C CA  . VAL A 1 191 ? -16.81352 23.55941 1.30583   1.000 23.96937 ? 191 VAL A CA  1 
ATOM   1425 C C   . VAL A 1 191 ? -17.91911 22.50971 1.32045   1.000 23.56153 ? 191 VAL A C   1 
ATOM   1426 O O   . VAL A 1 191 ? -17.71000 21.35460 0.90597   1.000 24.12368 ? 191 VAL A O   1 
ATOM   1427 C CB  . VAL A 1 191 ? -16.61497 24.08804 -0.13501  1.000 24.28641 ? 191 VAL A CB  1 
ATOM   1428 C CG1 . VAL A 1 191 ? -17.95884 24.63017 -0.68752  1.000 24.29547 ? 191 VAL A CG1 1 
ATOM   1429 C CG2 . VAL A 1 191 ? -15.56234 25.17236 -0.15744  1.000 28.37670 ? 191 VAL A CG2 1 
ATOM   1430 N N   . THR A 1 192 ? -19.12893 22.91651 1.75162   1.000 21.47790 ? 192 THR A N   1 
ATOM   1431 C CA  . THR A 1 192 ? -20.27998 22.01236 1.77454   1.000 21.39747 ? 192 THR A CA  1 
ATOM   1432 C C   . THR A 1 192 ? -21.11368 22.33470 0.54647   1.000 19.47856 ? 192 THR A C   1 
ATOM   1433 O O   . THR A 1 192 ? -21.49355 23.49160 0.35573   1.000 24.88390 ? 192 THR A O   1 
ATOM   1434 C CB  . THR A 1 192 ? -21.13299 22.20877 3.03881   1.000 24.20093 ? 192 THR A CB  1 
ATOM   1435 O OG1 . THR A 1 192 ? -20.33194 21.98255 4.19529   1.000 27.47481 ? 192 THR A OG1 1 
ATOM   1436 C CG2 . THR A 1 192 ? -22.31372 21.24342 3.05283   1.000 26.66420 ? 192 THR A CG2 1 
ATOM   1437 N N   . CYS A 1 193 ? -21.34830 21.33816 -0.29507  1.000 20.86484 ? 193 CYS A N   1 
ATOM   1438 C CA  . CYS A 1 193 ? -22.17230 21.44902 -1.48826  1.000 20.02419 ? 193 CYS A CA  1 
ATOM   1439 C C   . CYS A 1 193 ? -23.40755 20.56663 -1.34180  1.000 20.84671 ? 193 CYS A C   1 
ATOM   1440 O O   . CYS A 1 193 ? -23.39474 19.58478 -0.59366  1.000 23.96793 ? 193 CYS A O   1 
ATOM   1441 C CB  . CYS A 1 193 ? -21.41658 20.99974 -2.74529  1.000 20.56119 ? 193 CYS A CB  1 
ATOM   1442 S SG  . CYS A 1 193 ? -20.09069 22.13250 -3.14274  1.000 23.48917 ? 193 CYS A SG  1 
ATOM   1443 N N   . PRO A 1 194 ? -24.45961 20.83399 -2.11979  1.000 27.58530 ? 194 PRO A N   1 
ATOM   1444 C CA  . PRO A 1 194 ? -25.61047 19.91354 -2.14430  1.000 25.15657 ? 194 PRO A CA  1 
ATOM   1445 C C   . PRO A 1 194 ? -25.17074 18.52489 -2.53915  1.000 25.35974 ? 194 PRO A C   1 
ATOM   1446 O O   . PRO A 1 194 ? -24.28321 18.36042 -3.38141  1.000 24.31624 ? 194 PRO A O   1 
ATOM   1447 C CB  . PRO A 1 194 ? -26.52444 20.52103 -3.21351  1.000 27.66438 ? 194 PRO A CB  1 
ATOM   1448 C CG  . PRO A 1 194 ? -26.18154 21.96474 -3.21726  1.000 26.38765 ? 194 PRO A CG  1 
ATOM   1449 C CD  . PRO A 1 194 ? -24.67675 22.03313 -2.94320  1.000 29.37386 ? 194 PRO A CD  1 
ATOM   1450 N N   . GLY A 1 195 ? -25.81698 17.51330 -1.94395  1.000 22.67854 ? 195 GLY A N   1 
ATOM   1451 C CA  . GLY A 1 195 ? -25.57364 16.13073 -2.33795  1.000 19.65761 ? 195 GLY A CA  1 
ATOM   1452 C C   . GLY A 1 195 ? -25.78323 15.97735 -3.82511  1.000 26.06041 ? 195 GLY A C   1 
ATOM   1453 O O   . GLY A 1 195 ? -26.68752 16.61789 -4.38399  1.000 26.35044 ? 195 GLY A O   1 
ATOM   1454 N N   . SER A 1 196 ? -24.92911 15.18109 -4.48178  1.000 19.80385 ? 196 SER A N   1 
ATOM   1455 C CA  . SER A 1 196 ? -25.04742 14.87572 -5.90551  1.000 19.63527 ? 196 SER A CA  1 
ATOM   1456 C C   . SER A 1 196 ? -24.72899 16.07227 -6.80268  1.000 27.90331 ? 196 SER A C   1 
ATOM   1457 O O   . SER A 1 196 ? -25.24657 16.16386 -7.91533  1.000 26.23339 ? 196 SER A O   1 
ATOM   1458 C CB  . SER A 1 196 ? -26.44684 14.32224 -6.22494  1.000 24.05453 ? 196 SER A CB  1 
ATOM   1459 O OG  . SER A 1 196 ? -26.55923 13.07085 -5.59321  1.000 30.52218 ? 196 SER A OG  1 
ATOM   1460 N N   . SER A 1 197 ? -23.86379 16.98324 -6.34995  1.000 19.95049 ? 197 SER A N   1 
ATOM   1461 C CA  . SER A 1 197 ? -23.32769 18.02227 -7.22759  1.000 18.76694 ? 197 SER A CA  1 
ATOM   1462 C C   . SER A 1 197 ? -22.38436 17.38770 -8.25792  1.000 15.84520 ? 197 SER A C   1 
ATOM   1463 O O   . SER A 1 197 ? -21.93281 16.25903 -8.10233  1.000 22.23823 ? 197 SER A O   1 
ATOM   1464 C CB  . SER A 1 197 ? -22.59248 19.07916 -6.39596  1.000 20.71962 ? 197 SER A CB  1 
ATOM   1465 O OG  . SER A 1 197 ? -23.49384 19.80415 -5.52302  1.000 25.56079 ? 197 SER A OG  1 
ATOM   1466 N N   . ASN A 1 198 ? -22.04636 18.14863 -9.31244  1.000 18.19125 ? 198 ASN A N   1 
ATOM   1467 C CA  . ASN A 1 198 ? -21.01348 17.76434 -10.27127 1.000 16.30012 ? 198 ASN A CA  1 
ATOM   1468 C C   . ASN A 1 198 ? -19.90704 18.81221 -10.20464 1.000 15.38313 ? 198 ASN A C   1 
ATOM   1469 O O   . ASN A 1 198 ? -20.11359 19.91003 -9.69830  1.000 20.02793 ? 198 ASN A O   1 
ATOM   1470 C CB  . ASN A 1 198 ? -21.57881 17.69340 -11.69555 1.000 21.65463 ? 198 ASN A CB  1 
ATOM   1471 C CG  . ASN A 1 198 ? -22.62604 16.60241 -11.85145 1.000 25.12826 ? 198 ASN A CG  1 
ATOM   1472 O OD1 . ASN A 1 198 ? -22.46585 15.47933 -11.33903 1.000 24.02888 ? 198 ASN A OD1 1 
ATOM   1473 N ND2 . ASN A 1 198 ? -23.71534 16.92234 -12.56994 1.000 32.36891 ? 198 ASN A ND2 1 
ATOM   1474 N N   . TYR A 1 199 ? -18.72049 18.46468 -10.71652 1.000 16.89399 ? 199 TYR A N   1 
ATOM   1475 C CA  . TYR A 1 199 ? -17.53604 19.27032 -10.43116 1.000 15.32558 ? 199 TYR A CA  1 
ATOM   1476 C C   . TYR A 1 199 ? -16.60570 19.31823 -11.63234 1.000 15.50605 ? 199 TYR A C   1 
ATOM   1477 O O   . TYR A 1 199 ? -16.66287 18.48327 -12.52489 1.000 17.29451 ? 199 TYR A O   1 
ATOM   1478 C CB  . TYR A 1 199 ? -16.72772 18.67253 -9.25965  1.000 15.23069 ? 199 TYR A CB  1 
ATOM   1479 C CG  . TYR A 1 199 ? -17.57401 18.57260 -8.00327  1.000 17.08087 ? 199 TYR A CG  1 
ATOM   1480 C CD1 . TYR A 1 199 ? -17.69217 19.67380 -7.14219  1.000 18.61179 ? 199 TYR A CD1 1 
ATOM   1481 C CD2 . TYR A 1 199 ? -18.27036 17.39330 -7.70815  1.000 16.51669 ? 199 TYR A CD2 1 
ATOM   1482 C CE1 . TYR A 1 199 ? -18.47954 19.60689 -5.98278  1.000 17.99271 ? 199 TYR A CE1 1 
ATOM   1483 C CE2 . TYR A 1 199 ? -19.05200 17.32119 -6.53574  1.000 16.05308 ? 199 TYR A CE2 1 
ATOM   1484 C CZ  . TYR A 1 199 ? -19.15182 18.41442 -5.71122  1.000 18.56903 ? 199 TYR A CZ  1 
ATOM   1485 O OH  . TYR A 1 199 ? -19.92777 18.32223 -4.54326  1.000 21.97730 ? 199 TYR A OH  1 
ATOM   1486 N N   . ARG A 1 200 ? -15.70503 20.29456 -11.59529 1.000 16.64749 ? 200 ARG A N   1 
ATOM   1487 C CA  . ARG A 1 200 ? -14.60641 20.39460 -12.55401 1.000 13.88903 ? 200 ARG A CA  1 
ATOM   1488 C C   . ARG A 1 200 ? -13.31729 20.62507 -11.76166 1.000 18.49908 ? 200 ARG A C   1 
ATOM   1489 O O   . ARG A 1 200 ? -13.28514 21.48174 -10.86486 1.000 17.98716 ? 200 ARG A O   1 
ATOM   1490 C CB  . ARG A 1 200 ? -14.82481 21.55188 -13.54425 1.000 16.04695 ? 200 ARG A CB  1 
ATOM   1491 C CG  . ARG A 1 200 ? -13.63623 21.72823 -14.46598 1.000 17.02181 ? 200 ARG A CG  1 
ATOM   1492 C CD  . ARG A 1 200 ? -13.88294 22.86658 -15.47695 1.000 20.42724 ? 200 ARG A CD  1 
ATOM   1493 N NE  . ARG A 1 200 ? -14.94083 22.47126 -16.40235 1.000 21.28894 ? 200 ARG A NE  1 
ATOM   1494 C CZ  . ARG A 1 200 ? -16.10753 23.09068 -16.50797 1.000 27.80706 ? 200 ARG A CZ  1 
ATOM   1495 N NH1 . ARG A 1 200 ? -16.40908 24.13199 -15.74471 1.000 30.71666 ? 200 ARG A NH1 1 
ATOM   1496 N NH2 . ARG A 1 200 ? -16.98370 22.66835 -17.42930 1.000 29.88790 ? 200 ARG A NH2 1 
ATOM   1497 N N   . VAL A 1 201 ? -12.28319 19.86006 -12.08129 1.000 16.43314 ? 201 VAL A N   1 
ATOM   1498 C CA  . VAL A 1 201 ? -10.94973 20.08995 -11.53210 1.000 16.48009 ? 201 VAL A CA  1 
ATOM   1499 C C   . VAL A 1 201 ? -10.12466 20.61327 -12.68110 1.000 15.20397 ? 201 VAL A C   1 
ATOM   1500 O O   . VAL A 1 201 ? -9.99185  19.92442 -13.70242 1.000 15.69658 ? 201 VAL A O   1 
ATOM   1501 C CB  . VAL A 1 201 ? -10.32936 18.80144 -10.96694 1.000 15.87130 ? 201 VAL A CB  1 
ATOM   1502 C CG1 . VAL A 1 201 ? -8.89927  19.08257 -10.47223 1.000 17.52750 ? 201 VAL A CG1 1 
ATOM   1503 C CG2 . VAL A 1 201 ? -11.20761 18.25278 -9.81871  1.000 15.53975 ? 201 VAL A CG2 1 
ATOM   1504 N N   . THR A 1 202 ? -9.52355  21.78844 -12.49882 1.000 15.46388 ? 202 THR A N   1 
ATOM   1505 C CA  . THR A 1 202 ? -8.70954  22.40604 -13.54256 1.000 15.40856 ? 202 THR A CA  1 
ATOM   1506 C C   . THR A 1 202 ? -7.28566  22.51381 -13.02502 1.000 15.34639 ? 202 THR A C   1 
ATOM   1507 O O   . THR A 1 202 ? -7.05503  23.21354 -12.03677 1.000 18.43924 ? 202 THR A O   1 
ATOM   1508 C CB  . THR A 1 202 ? -9.21532  23.80629 -13.90928 1.000 17.30478 ? 202 THR A CB  1 
ATOM   1509 O OG1 . THR A 1 202 ? -10.61450 23.73000 -14.25016 1.000 17.42165 ? 202 THR A OG1 1 
ATOM   1510 C CG2 . THR A 1 202 ? -8.40825  24.42887 -15.09099 1.000 18.38340 ? 202 THR A CG2 1 
ATOM   1511 N N   . PHE A 1 203 ? -6.35393  21.89104 -13.73265 1.000 15.18904 ? 203 PHE A N   1 
ATOM   1512 C CA  . PHE A 1 203 ? -4.93100  22.07194 -13.44260 1.000 15.64023 ? 203 PHE A CA  1 
ATOM   1513 C C   . PHE A 1 203 ? -4.43507  23.33654 -14.12980 1.000 18.10748 ? 203 PHE A C   1 
ATOM   1514 O O   . PHE A 1 203 ? -4.82948  23.62232 -15.26763 1.000 16.80861 ? 203 PHE A O   1 
ATOM   1515 C CB  . PHE A 1 203 ? -4.14049  20.86398 -13.92246 1.000 13.92806 ? 203 PHE A CB  1 
ATOM   1516 C CG  . PHE A 1 203 ? -4.60494  19.55461 -13.32343 1.000 15.49921 ? 203 PHE A CG  1 
ATOM   1517 C CD1 . PHE A 1 203 ? -4.59134  19.38239 -11.96282 1.000 18.03773 ? 203 PHE A CD1 1 
ATOM   1518 C CD2 . PHE A 1 203 ? -5.01271  18.50275 -14.14136 1.000 18.29104 ? 203 PHE A CD2 1 
ATOM   1519 C CE1 . PHE A 1 203 ? -4.99724  18.16134 -11.40785 1.000 19.02240 ? 203 PHE A CE1 1 
ATOM   1520 C CE2 . PHE A 1 203 ? -5.38487  17.29921 -13.59253 1.000 21.12742 ? 203 PHE A CE2 1 
ATOM   1521 C CZ  . PHE A 1 203 ? -5.39955  17.14909 -12.22543 1.000 16.08123 ? 203 PHE A CZ  1 
ATOM   1522 N N   . CYS A 1 204 ? -3.58764  24.11154 -13.43554 1.000 14.58763 ? 204 CYS A N   1 
ATOM   1523 C CA  . CYS A 1 204 ? -3.08720  25.39996 -13.92133 1.000 15.00059 ? 204 CYS A CA  1 
ATOM   1524 C C   . CYS A 1 204 ? -4.22234  26.34986 -14.32504 1.000 17.52471 ? 204 CYS A C   1 
ATOM   1525 O O   . CYS A 1 204 ? -4.29415  26.78873 -15.47752 1.000 17.98056 ? 204 CYS A O   1 
ATOM   1526 C CB  . CYS A 1 204 ? -2.11657  25.22543 -15.07925 1.000 17.61211 ? 204 CYS A CB  1 
ATOM   1527 S SG  . CYS A 1 204 ? -0.66569  24.21797 -14.68060 1.000 16.71774 ? 204 CYS A SG  1 
ATOM   1528 N N   . PRO A 1 205 ? -5.09787  26.71605 -13.37659 1.000 17.11526 ? 205 PRO A N   1 
ATOM   1529 C CA  . PRO A 1 205 ? -6.28466  27.48206 -13.74350 1.000 18.44776 ? 205 PRO A CA  1 
ATOM   1530 C C   . PRO A 1 205 ? -5.96252  28.87698 -14.22114 1.000 24.36914 ? 205 PRO A C   1 
ATOM   1531 O O   . PRO A 1 205 ? -6.78755  29.46532 -14.92234 1.000 23.28656 ? 205 PRO A O   1 
ATOM   1532 C CB  . PRO A 1 205 ? -7.10248  27.52014 -12.43851 1.000 20.51110 ? 205 PRO A CB  1 
ATOM   1533 C CG  . PRO A 1 205 ? -6.09710  27.33783 -11.34222 1.000 19.13528 ? 205 PRO A CG  1 
ATOM   1534 C CD  . PRO A 1 205 ? -5.12898  26.30943 -11.95347 1.000 19.06857 ? 205 PRO A CD  1 
ATOM   1535 N N   . THR A 1 206 ? -4.81836  29.41256 -13.83890 1.000 19.17916 ? 206 THR A N   1 
ATOM   1536 C CA  . THR A 1 206 ? -4.36013  30.75062 -14.22434 1.000 34.75743 ? 206 THR A CA  1 
ATOM   1537 C C   . THR A 1 206 ? -3.42252  30.73572 -15.43655 1.000 47.67150 ? 206 THR A C   1 
ATOM   1538 O O   . THR A 1 206 ? -3.57361  31.53454 -16.35504 1.000 59.69067 ? 206 THR A O   1 
ATOM   1539 C CB  . THR A 1 206 ? -3.62131  31.38508 -13.05126 1.000 39.27004 ? 206 THR A CB  1 
ATOM   1540 O OG1 . THR A 1 206 ? -4.55710  31.56923 -11.99205 1.000 44.77120 ? 206 THR A OG1 1 
ATOM   1541 C CG2 . THR A 1 206 ? -3.00334  32.70068 -13.46950 1.000 65.36115 ? 206 THR A CG2 1 
HETATM 1542 O O1  . TLA B 2 .   ? -10.82232 12.32840 -24.45028 1.000 26.78958 ? 301 TLA A O1  1 
HETATM 1543 O O11 . TLA B 2 .   ? -10.56833 12.51134 -26.65247 1.000 26.55112 ? 301 TLA A O11 1 
HETATM 1544 C C1  . TLA B 2 .   ? -10.44629 12.90786 -25.46870 1.000 28.81952 ? 301 TLA A C1  1 
HETATM 1545 C C2  . TLA B 2 .   ? -9.76008  14.28138 -25.29400 1.000 22.93534 ? 301 TLA A C2  1 
HETATM 1546 O O2  . TLA B 2 .   ? -9.42073  14.52478 -23.91408 1.000 20.70769 ? 301 TLA A O2  1 
HETATM 1547 C C3  . TLA B 2 .   ? -10.68458 15.37423 -25.81877 1.000 17.31246 ? 301 TLA A C3  1 
HETATM 1548 O O3  . TLA B 2 .   ? -11.86485 15.36905 -25.04641 1.000 20.94306 ? 301 TLA A O3  1 
HETATM 1549 C C4  . TLA B 2 .   ? -10.00352 16.74071 -25.64547 1.000 17.24338 ? 301 TLA A C4  1 
HETATM 1550 O O4  . TLA B 2 .   ? -9.04225  16.95557 -26.43286 1.000 19.29361 ? 301 TLA A O4  1 
HETATM 1551 O O41 . TLA B 2 .   ? -10.45376 17.46584 -24.73878 1.000 19.07803 ? 301 TLA A O41 1 
HETATM 1552 O O   . HOH C 3 .   ? -13.04403 27.28417 1.93518   1.000 47.30857 ? 401 HOH A O   1 
HETATM 1553 O O   . HOH C 3 .   ? -9.96785  29.64822 -3.06739  1.000 32.08411 ? 402 HOH A O   1 
HETATM 1554 O O   . HOH C 3 .   ? 6.24070   32.05350 4.24214   1.000 58.31129 ? 403 HOH A O   1 
HETATM 1555 O O   . HOH C 3 .   ? -21.68483 4.33554  -11.20914 1.000 65.18302 ? 404 HOH A O   1 
HETATM 1556 O O   . HOH C 3 .   ? 1.81541   9.98181  12.02434  1.000 37.09320 ? 405 HOH A O   1 
HETATM 1557 O O   . HOH C 3 .   ? -21.631   17.012   -15.807   1.000 55.99316 ? 406 HOH A O   1 
HETATM 1558 O O   . HOH C 3 .   ? 8.05406   16.60913 -12.45133 1.000 34.34809 ? 407 HOH A O   1 
HETATM 1559 O O   . HOH C 3 .   ? -0.37814  29.87525 -11.15544 1.000 55.11349 ? 408 HOH A O   1 
HETATM 1560 O O   . HOH C 3 .   ? -3.56126  0.63319  -18.34590 1.000 51.04637 ? 409 HOH A O   1 
HETATM 1561 O O   . HOH C 3 .   ? -4.02563  27.75809 10.12402  1.000 37.63794 ? 410 HOH A O   1 
HETATM 1562 O O   . HOH C 3 .   ? -7.00415  5.30087  -18.97316 1.000 32.28820 ? 411 HOH A O   1 
HETATM 1563 O O   . HOH C 3 .   ? -21.79836 14.48448 -6.03830  1.000 22.19393 ? 412 HOH A O   1 
HETATM 1564 O O   . HOH C 3 .   ? 1.51922   14.95853 16.98179  1.000 30.85574 ? 413 HOH A O   1 
HETATM 1565 O O   . HOH C 3 .   ? 6.35999   31.76046 9.51175   1.000 48.65995 ? 414 HOH A O   1 
HETATM 1566 O O   . HOH C 3 .   ? -5.00299  15.73445 2.75992   1.000 26.41648 ? 415 HOH A O   1 
HETATM 1567 O O   . HOH C 3 .   ? -15.01225 24.60249 6.34551   1.000 39.45885 ? 416 HOH A O   1 
HETATM 1568 O O   . HOH C 3 .   ? -12.29737 24.04787 -11.91700 1.000 20.52877 ? 417 HOH A O   1 
HETATM 1569 O O   . HOH C 3 .   ? -4.34879  26.50872 13.00919  1.000 49.22620 ? 418 HOH A O   1 
HETATM 1570 O O   . HOH C 3 .   ? -23.44439 15.65927 6.29711   1.000 37.82358 ? 419 HOH A O   1 
HETATM 1571 O O   . HOH C 3 .   ? -25.21208 21.26033 -6.88920  1.000 32.41330 ? 420 HOH A O   1 
HETATM 1572 O O   . HOH C 3 .   ? -10.18237 23.71826 0.61403   1.000 21.78524 ? 421 HOH A O   1 
HETATM 1573 O O   . HOH C 3 .   ? -20.65008 6.72961  1.93297   1.000 45.00041 ? 422 HOH A O   1 
HETATM 1574 O O   . HOH C 3 .   ? 2.89479   24.92748 -13.17751 1.000 32.37829 ? 423 HOH A O   1 
HETATM 1575 O O   . HOH C 3 .   ? 0.10068   12.46477 9.07008   1.000 39.04243 ? 424 HOH A O   1 
HETATM 1576 O O   . HOH C 3 .   ? 11.68501  24.86229 -6.25490  1.000 51.50408 ? 425 HOH A O   1 
HETATM 1577 O O   . HOH C 3 .   ? -7.32400  15.49802 -28.01263 1.000 20.64884 ? 426 HOH A O   1 
HETATM 1578 O O   . HOH C 3 .   ? -17.09364 7.21835  -17.36430 1.000 49.05816 ? 427 HOH A O   1 
HETATM 1579 O O   . HOH C 3 .   ? -8.07726  27.54013 7.38794   1.000 32.73643 ? 428 HOH A O   1 
HETATM 1580 O O   . HOH C 3 .   ? -20.47586 4.37299  -3.24089  1.000 43.01111 ? 429 HOH A O   1 
HETATM 1581 O O   . HOH C 3 .   ? -3.35341  23.11248 15.75064  1.000 35.00039 ? 430 HOH A O   1 
HETATM 1582 O O   . HOH C 3 .   ? -10.66502 20.00280 -23.78392 1.000 17.59728 ? 431 HOH A O   1 
HETATM 1583 O O   . HOH C 3 .   ? -7.49454  24.63032 5.92692   1.000 35.58294 ? 432 HOH A O   1 
HETATM 1584 O O   . HOH C 3 .   ? 4.76912   16.46574 -17.11968 1.000 20.66782 ? 433 HOH A O   1 
HETATM 1585 O O   . HOH C 3 .   ? -16.871   20.587   -21.472   1.000 23.08046 ? 434 HOH A O   1 
HETATM 1586 O O   . HOH C 3 .   ? -0.20753  26.60116 8.87979   1.000 18.09413 ? 435 HOH A O   1 
HETATM 1587 O O   . HOH C 3 .   ? -17.93772 22.82905 5.13485   1.000 49.77917 ? 436 HOH A O   1 
HETATM 1588 O O   . HOH C 3 .   ? 1.82279   20.96327 4.30912   1.000 22.34471 ? 437 HOH A O   1 
HETATM 1589 O O   . HOH C 3 .   ? 2.58708   20.79747 -24.33227 1.000 45.29514 ? 438 HOH A O   1 
HETATM 1590 O O   . HOH C 3 .   ? -11.30146 9.65105  -24.44221 1.000 46.95817 ? 439 HOH A O   1 
HETATM 1591 O O   . HOH C 3 .   ? -1.47921  17.57582 -0.62338  1.000 16.84851 ? 440 HOH A O   1 
HETATM 1592 O O   . HOH C 3 .   ? -5.10198  19.78045 -26.71127 1.000 21.26532 ? 441 HOH A O   1 
HETATM 1593 O O   . HOH C 3 .   ? -13.49389 1.90421  -11.53891 1.000 49.59285 ? 442 HOH A O   1 
HETATM 1594 O O   . HOH C 3 .   ? 3.54392   12.22414 4.05725   1.000 39.75732 ? 443 HOH A O   1 
HETATM 1595 O O   . HOH C 3 .   ? -7.03592  16.69343 8.44305   1.000 48.10865 ? 444 HOH A O   1 
HETATM 1596 O O   . HOH C 3 .   ? -22.72203 19.72357 -14.31863 1.000 49.19011 ? 445 HOH A O   1 
HETATM 1597 O O   . HOH C 3 .   ? -1.90664  17.37400 -8.22674  1.000 16.58857 ? 446 HOH A O   1 
HETATM 1598 O O   . HOH C 3 .   ? -5.84417  29.36691 -1.68119  1.000 22.04316 ? 447 HOH A O   1 
HETATM 1599 O O   . HOH C 3 .   ? -0.85019  11.84178 -2.43577  1.000 24.71723 ? 448 HOH A O   1 
HETATM 1600 O O   . HOH C 3 .   ? 1.09771   7.94275  -21.31422 1.000 36.08151 ? 449 HOH A O   1 
HETATM 1601 O O   . HOH C 3 .   ? -15.73090 4.34747  -10.53550 1.000 49.05471 ? 450 HOH A O   1 
HETATM 1602 O O   . HOH C 3 .   ? 3.23653   27.14703 16.17441  1.000 22.54996 ? 451 HOH A O   1 
HETATM 1603 O O   . HOH C 3 .   ? -13.37654 21.46601 -20.70462 1.000 19.26660 ? 452 HOH A O   1 
HETATM 1604 O O   . HOH C 3 .   ? 5.42537   9.77122  -21.49311 1.000 45.48475 ? 453 HOH A O   1 
HETATM 1605 O O   . HOH C 3 .   ? 4.31297   26.40024 -8.68225  1.000 23.99140 ? 454 HOH A O   1 
HETATM 1606 O O   . HOH C 3 .   ? -12.57476 28.93010 -7.43503  1.000 43.23869 ? 455 HOH A O   1 
HETATM 1607 O O   . HOH C 3 .   ? -3.84643  12.22556 -24.24737 1.000 29.18286 ? 456 HOH A O   1 
HETATM 1608 O O   . HOH C 3 .   ? -16.82174 5.44008  -8.30165  1.000 39.37624 ? 457 HOH A O   1 
HETATM 1609 O O   . HOH C 3 .   ? 2.75357   36.27827 0.61341   1.000 53.09391 ? 458 HOH A O   1 
HETATM 1610 O O   . HOH C 3 .   ? 14.10295  25.52457 7.07572   1.000 46.62190 ? 459 HOH A O   1 
HETATM 1611 O O   . HOH C 3 .   ? -24.59437 14.31969 -9.87769  1.000 34.56657 ? 460 HOH A O   1 
HETATM 1612 O O   . HOH C 3 .   ? -22.93227 11.82317 -6.14912  1.000 23.00199 ? 461 HOH A O   1 
HETATM 1613 O O   . HOH C 3 .   ? 8.60905   13.17964 -2.09507  1.000 35.11113 ? 462 HOH A O   1 
HETATM 1614 O O   . HOH C 3 .   ? 11.56632  27.81509 6.09838   1.000 46.51100 ? 463 HOH A O   1 
HETATM 1615 O O   . HOH C 3 .   ? -14.18238 2.54013  -6.99018  1.000 59.76757 ? 464 HOH A O   1 
HETATM 1616 O O   . HOH C 3 .   ? -24.32507 28.72108 -6.61552  1.000 53.89152 ? 465 HOH A O   1 
HETATM 1617 O O   . HOH C 3 .   ? 7.26910   11.88056 -5.91119  1.000 24.81365 ? 466 HOH A O   1 
HETATM 1618 O O   . HOH C 3 .   ? -8.30889  19.83667 10.42175  1.000 32.08315 ? 467 HOH A O   1 
HETATM 1619 O O   . HOH C 3 .   ? -18.91944 18.22049 -14.14674 1.000 29.74801 ? 468 HOH A O   1 
HETATM 1620 O O   . HOH C 3 .   ? 6.78072   0.38154  -12.84962 1.000 38.78535 ? 469 HOH A O   1 
HETATM 1621 O O   . HOH C 3 .   ? -11.80015 26.07769 -15.21271 1.000 43.00012 ? 470 HOH A O   1 
HETATM 1622 O O   . HOH C 3 .   ? 3.46750   21.20761 9.88521   1.000 18.54054 ? 471 HOH A O   1 
HETATM 1623 O O   . HOH C 3 .   ? 0.39516   17.39808 8.67867   1.000 42.09449 ? 472 HOH A O   1 
HETATM 1624 O O   . HOH C 3 .   ? 4.48865   11.09174 3.08847   1.000 45.15305 ? 473 HOH A O   1 
HETATM 1625 O O   . HOH C 3 .   ? 15.73352  18.52973 3.05113   1.000 37.57718 ? 474 HOH A O   1 
HETATM 1626 O O   . HOH C 3 .   ? -3.75190  31.81486 -3.38224  1.000 49.63674 ? 475 HOH A O   1 
HETATM 1627 O O   . HOH C 3 .   ? -24.12002 11.46458 -8.35282  1.000 31.76521 ? 476 HOH A O   1 
HETATM 1628 O O   . HOH C 3 .   ? -1.88448  35.22592 2.55790   1.000 53.72179 ? 477 HOH A O   1 
HETATM 1629 O O   . HOH C 3 .   ? 1.68506   18.11896 6.09507   1.000 32.61610 ? 478 HOH A O   1 
HETATM 1630 O O   . HOH C 3 .   ? -26.85162 10.90414 -7.35632  1.000 45.90508 ? 479 HOH A O   1 
HETATM 1631 O O   . HOH C 3 .   ? 9.47919   14.68346 -6.98589  1.000 31.80747 ? 480 HOH A O   1 
HETATM 1632 O O   . HOH C 3 .   ? -10.47258 12.47261 0.23939   1.000 24.04821 ? 481 HOH A O   1 
HETATM 1633 O O   . HOH C 3 .   ? 5.20437   16.59059 18.77279  1.000 23.23618 ? 482 HOH A O   1 
HETATM 1634 O O   . HOH C 3 .   ? -14.622   16.361   -21.311   1.000 42.32815 ? 483 HOH A O   1 
HETATM 1635 O O   . HOH C 3 .   ? 7.19627   12.50669 -19.65117 1.000 31.97399 ? 484 HOH A O   1 
HETATM 1636 O O   . HOH C 3 .   ? 0.24007   18.16975 10.58847  1.000 32.72183 ? 485 HOH A O   1 
HETATM 1637 O O   . HOH C 3 .   ? -13.59590 16.61591 1.56245   1.000 29.23809 ? 486 HOH A O   1 
HETATM 1638 O O   . HOH C 3 .   ? -15.31125 28.73889 -8.54582  1.000 44.37787 ? 487 HOH A O   1 
HETATM 1639 O O   . HOH C 3 .   ? 8.75071   29.54467 -10.75953 1.000 47.68128 ? 488 HOH A O   1 
HETATM 1640 O O   . HOH C 3 .   ? 0.90311   18.74691 -23.80290 1.000 26.18060 ? 489 HOH A O   1 
HETATM 1641 O O   . HOH C 3 .   ? -21.46683 26.23412 1.08561   1.000 53.35893 ? 490 HOH A O   1 
HETATM 1642 O O   . HOH C 3 .   ? 0.71617   8.40076  -0.60571  1.000 39.88458 ? 491 HOH A O   1 
HETATM 1643 O O   . HOH C 3 .   ? 1.69736   27.32074 -9.53700  1.000 37.86021 ? 492 HOH A O   1 
HETATM 1644 O O   . HOH C 3 .   ? -12.05015 5.59644  0.79178   1.000 41.63065 ? 493 HOH A O   1 
HETATM 1645 O O   . HOH C 3 .   ? 4.03142   4.89956  -5.48384  1.000 42.68109 ? 494 HOH A O   1 
HETATM 1646 O O   . HOH C 3 .   ? 9.99861   30.34062 1.16980   1.000 36.52233 ? 495 HOH A O   1 
HETATM 1647 O O   . HOH C 3 .   ? 1.93216   14.36943 5.03037   1.000 29.62965 ? 496 HOH A O   1 
HETATM 1648 O O   . HOH C 3 .   ? -7.92297  30.65669 5.26541   1.000 50.34047 ? 497 HOH A O   1 
HETATM 1649 O O   . HOH C 3 .   ? 2.44097   33.04838 -6.35740  1.000 36.87781 ? 498 HOH A O   1 
HETATM 1650 O O   . HOH C 3 .   ? 4.35355   23.35380 16.04854  1.000 19.77251 ? 499 HOH A O   1 
HETATM 1651 O O   . HOH C 3 .   ? -7.69065  16.97918 4.42691   1.000 53.51731 ? 500 HOH A O   1 
HETATM 1652 O O   . HOH C 3 .   ? 6.76734   30.43224 7.15418   1.000 23.14466 ? 501 HOH A O   1 
HETATM 1653 O O   . HOH C 3 .   ? -9.89467  7.27980  1.19118   1.000 63.16286 ? 502 HOH A O   1 
HETATM 1654 O O   . HOH C 3 .   ? -2.03527  2.14195  -8.08905  1.000 30.04865 ? 503 HOH A O   1 
HETATM 1655 O O   . HOH C 3 .   ? 1.85883   6.24172  -11.45519 1.000 20.27327 ? 504 HOH A O   1 
HETATM 1656 O O   . HOH C 3 .   ? -24.51291 7.71368  0.83934   1.000 40.60497 ? 505 HOH A O   1 
HETATM 1657 O O   . HOH C 3 .   ? 12.65213  28.50089 -3.80470  1.000 37.30947 ? 506 HOH A O   1 
HETATM 1658 O O   . HOH C 3 .   ? -12.87011 13.71269 1.79568   1.000 38.20301 ? 507 HOH A O   1 
HETATM 1659 O O   . HOH C 3 .   ? 0.81460   31.74206 7.13463   1.000 28.73340 ? 508 HOH A O   1 
HETATM 1660 O O   . HOH C 3 .   ? -25.246   3.477    -7.672    1.000 44.51241 ? 509 HOH A O   1 
HETATM 1661 O O   . HOH C 3 .   ? 3.24116   23.98734 -24.63050 1.000 43.01036 ? 510 HOH A O   1 
HETATM 1662 O O   . HOH C 3 .   ? -2.95489  32.68244 5.04133   1.000 38.63927 ? 511 HOH A O   1 
HETATM 1663 O O   . HOH C 3 .   ? -3.84902  13.03586 13.48725  1.000 48.31670 ? 512 HOH A O   1 
HETATM 1664 O O   . HOH C 3 .   ? 1.93024   20.24721 12.09501  1.000 18.22575 ? 513 HOH A O   1 
HETATM 1665 O O   . HOH C 3 .   ? -3.77320  7.80051  -21.29088 1.000 23.10342 ? 514 HOH A O   1 
HETATM 1666 O O   . HOH C 3 .   ? -4.85592  30.62565 -5.29522  1.000 32.76705 ? 515 HOH A O   1 
HETATM 1667 O O   . HOH C 3 .   ? -26.794   11.109   1.486     1.000 27.77869 ? 516 HOH A O   1 
HETATM 1668 O O   . HOH C 3 .   ? 12.94820  28.59729 -7.36490  1.000 43.57213 ? 517 HOH A O   1 
HETATM 1669 O O   . HOH C 3 .   ? 11.84464  16.34190 -15.39055 1.000 44.64356 ? 518 HOH A O   1 
HETATM 1670 O O   . HOH C 3 .   ? -29.19931 13.01095 -4.36585  1.000 47.41496 ? 519 HOH A O   1 
HETATM 1671 O O   . HOH C 3 .   ? 9.781     10.431   14.627    1.000 28.13455 ? 520 HOH A O   1 
HETATM 1672 O O   . HOH C 3 .   ? -2.96239  10.75161 -3.95338  1.000 24.32332 ? 521 HOH A O   1 
HETATM 1673 O O   . HOH C 3 .   ? -3.54701  4.16374  -1.19811  1.000 30.03349 ? 522 HOH A O   1 
HETATM 1674 O O   . HOH C 3 .   ? -0.76643  33.84064 -2.83457  1.000 45.33867 ? 523 HOH A O   1 
HETATM 1675 O O   . HOH C 3 .   ? 12.88982  17.84397 0.34197   1.000 30.63029 ? 524 HOH A O   1 
HETATM 1676 O O   . HOH C 3 .   ? -17.24403 25.72619 -12.47474 1.000 41.51750 ? 525 HOH A O   1 
HETATM 1677 O O   . HOH C 3 .   ? 1.46864   25.93411 -17.38016 1.000 26.82361 ? 526 HOH A O   1 
HETATM 1678 O O   . HOH C 3 .   ? 5.68275   34.99598 -1.72982  1.000 49.40497 ? 527 HOH A O   1 
HETATM 1679 O O   . HOH C 3 .   ? -2.24482  25.58484 2.30170   1.000 17.72176 ? 528 HOH A O   1 
HETATM 1680 O O   . HOH C 3 .   ? 4.35079   21.16861 5.63658   1.000 20.62020 ? 529 HOH A O   1 
HETATM 1681 O O   . HOH C 3 .   ? -9.70737  -0.53707 -8.83033  1.000 36.78629 ? 530 HOH A O   1 
HETATM 1682 O O   . HOH C 3 .   ? -2.46397  28.19365 -17.30841 1.000 42.18346 ? 531 HOH A O   1 
HETATM 1683 O O   . HOH C 3 .   ? 1.63828   -1.52962 -8.30798  1.000 49.35240 ? 532 HOH A O   1 
HETATM 1684 O O   . HOH C 3 .   ? -16.62141 5.01664  -0.44986  1.000 36.90811 ? 533 HOH A O   1 
HETATM 1685 O O   . HOH C 3 .   ? 13.801    14.573   11.460    1.000 35.21520 ? 534 HOH A O   1 
HETATM 1686 O O   . HOH C 3 .   ? 7.76162   11.28759 -1.48088  1.000 47.54038 ? 535 HOH A O   1 
HETATM 1687 O O   . HOH C 3 .   ? -19.40413 25.53270 3.10927   1.000 41.48610 ? 536 HOH A O   1 
HETATM 1688 O O   . HOH C 3 .   ? 2.04471   9.45813  1.77872   1.000 49.41861 ? 537 HOH A O   1 
HETATM 1689 O O   . HOH C 3 .   ? -17.37102 4.28053  -4.12203  1.000 58.29237 ? 538 HOH A O   1 
HETATM 1690 O O   . HOH C 3 .   ? 7.04083   3.27316  -10.22827 1.000 36.69521 ? 539 HOH A O   1 
HETATM 1691 O O   . HOH C 3 .   ? 7.59628   -0.90660 -15.17233 1.000 46.50572 ? 540 HOH A O   1 
HETATM 1692 O O   . HOH C 3 .   ? -9.42634  9.00621  1.82448   1.000 52.88047 ? 541 HOH A O   1 
HETATM 1693 O O   . HOH C 3 .   ? 2.43558   20.50010 7.39876   1.000 37.46493 ? 542 HOH A O   1 
HETATM 1694 O O   . HOH C 3 .   ? 4.90853   32.15737 5.77283   1.000 29.41447 ? 543 HOH A O   1 
HETATM 1695 O O   . HOH C 3 .   ? -2.25177  0.88489  -15.46921 1.000 32.09052 ? 544 HOH A O   1 
HETATM 1696 O O   . HOH C 3 .   ? 6.27907   10.18256 -7.89242  1.000 19.66916 ? 545 HOH A O   1 
HETATM 1697 O O   . HOH C 3 .   ? -13.78361 12.01790 -21.45568 1.000 34.76101 ? 546 HOH A O   1 
HETATM 1698 O O   . HOH C 3 .   ? 4.83306   18.07888 -21.61443 1.000 29.39233 ? 547 HOH A O   1 
HETATM 1699 O O   . HOH C 3 .   ? 4.12146   23.93749 -10.54781 1.000 33.88339 ? 548 HOH A O   1 
HETATM 1700 O O   . HOH C 3 .   ? 3.29971   19.15648 7.98670   1.000 35.68284 ? 549 HOH A O   1 
HETATM 1701 O O   . HOH C 3 .   ? 14.47210  25.56617 4.12514   1.000 31.54167 ? 550 HOH A O   1 
HETATM 1702 O O   . HOH C 3 .   ? 11.37290  21.41319 -7.02732  1.000 34.00837 ? 551 HOH A O   1 
HETATM 1703 O O   . HOH C 3 .   ? -27.38775 12.80457 -1.12626  1.000 34.47727 ? 552 HOH A O   1 
HETATM 1704 O O   . HOH C 3 .   ? -2.22608  28.35382 -12.64532 1.000 29.74979 ? 553 HOH A O   1 
HETATM 1705 O O   . HOH C 3 .   ? -8.19295  12.92533 -28.51062 1.000 30.11945 ? 554 HOH A O   1 
HETATM 1706 O O   . HOH C 3 .   ? -11.15528 9.10727  -21.83498 1.000 40.23259 ? 555 HOH A O   1 
HETATM 1707 O O   . HOH C 3 .   ? -12.62642 0.39558  -9.26217  1.000 54.36924 ? 556 HOH A O   1 
HETATM 1708 O O   . HOH C 3 .   ? 14.676    28.844   1.342     1.000 39.67422 ? 557 HOH A O   1 
HETATM 1709 O O   . HOH C 3 .   ? -10.36665 15.66649 3.58455   1.000 49.25236 ? 558 HOH A O   1 
HETATM 1710 O O   . HOH C 3 .   ? -9.27388  0.98832  -13.60943 1.000 55.44104 ? 559 HOH A O   1 
HETATM 1711 O O   . HOH C 3 .   ? -3.73349  30.03834 -19.14858 1.000 49.17009 ? 560 HOH A O   1 
HETATM 1712 O O   . HOH C 3 .   ? -20.16498 27.72344 -0.47510  1.000 41.94151 ? 561 HOH A O   1 
HETATM 1713 O O   . HOH C 3 .   ? 2.42920   5.27779  -4.13627  1.000 52.96562 ? 562 HOH A O   1 
HETATM 1714 O O   . HOH C 3 .   ? -16.36600 4.31905  -5.68818  1.000 60.47058 ? 563 HOH A O   1 
HETATM 1715 O O   . HOH C 3 .   ? 9.10507   27.78809 5.58880   1.000 36.30081 ? 564 HOH A O   1 
HETATM 1716 O O   . HOH C 3 .   ? 3.07343   15.44451 20.43676  1.000 51.53985 ? 565 HOH A O   1 
HETATM 1717 O O   . HOH C 3 .   ? 8.12230   4.74001  -21.88853 1.000 52.71605 ? 566 HOH A O   1 
HETATM 1718 O O   . HOH C 3 .   ? 6.41576   18.51314 -16.35299 1.000 36.94695 ? 567 HOH A O   1 
HETATM 1719 O O   . HOH C 3 .   ? -3.87888  17.39516 -27.60145 1.000 25.62119 ? 568 HOH A O   1 
HETATM 1720 O O   . HOH C 3 .   ? -24.723   4.704    -9.811    1.000 60.07968 ? 569 HOH A O   1 
HETATM 1721 O O   . HOH C 3 .   ? -19.74163 24.59698 -16.55695 1.000 53.00693 ? 570 HOH A O   1 
HETATM 1722 O O   . HOH C 3 .   ? -14.43780 25.48205 -13.23519 1.000 34.16281 ? 571 HOH A O   1 
HETATM 1723 O O   . HOH C 3 .   ? -6.71662  11.62651 -26.30533 1.000 46.11728 ? 572 HOH A O   1 
HETATM 1724 O O   . HOH C 3 .   ? -1.46143  8.23958  -25.01661 1.000 57.35162 ? 573 HOH A O   1 
HETATM 1725 O O   . HOH C 3 .   ? -7.85130  31.54521 -4.41245  1.000 50.43378 ? 574 HOH A O   1 
HETATM 1726 O O   . HOH C 3 .   ? 6.03769   15.89054 -19.75723 1.000 46.08840 ? 575 HOH A O   1 
HETATM 1727 O O   . HOH C 3 .   ? -4.64487  9.34911  -23.65263 1.000 47.78323 ? 576 HOH A O   1 
HETATM 1728 O O   . HOH C 3 .   ? -5.48357  5.48446  -21.26379 1.000 39.82853 ? 577 HOH A O   1 
HETATM 1729 O O   . HOH C 3 .   ? -9.53926  0.40024  -16.52248 1.000 62.07231 ? 578 HOH A O   1 
HETATM 1730 O O   . HOH C 3 .   ? -0.29991  28.02707 -17.61351 1.000 60.12413 ? 579 HOH A O   1 
HETATM 1731 O O   . HOH C 3 .   ? 0.59547   14.65059 7.51920   1.000 44.93982 ? 580 HOH A O   1 
HETATM 1732 O O   . HOH C 3 .   ? -6.62766  29.42126 9.55940   1.000 54.21761 ? 581 HOH A O   1 
HETATM 1733 O O   . HOH C 3 .   ? -1.51840  6.61762  -22.50282 1.000 56.86311 ? 582 HOH A O   1 
HETATM 1734 O O   . HOH C 3 .   ? -9.87310  6.12712  -20.04738 1.000 52.64739 ? 583 HOH A O   1 
HETATM 1735 O O   . HOH C 3 .   ? -3.73308  13.20387 3.12817   1.000 56.75328 ? 584 HOH A O   1 
HETATM 1736 O O   . HOH C 3 .   ? -1.15535  -0.26728 -6.96898  1.000 39.63069 ? 585 HOH A O   1 
HETATM 1737 O O   . HOH C 3 .   ? 5.29412   25.74481 -14.48160 1.000 54.55845 ? 586 HOH A O   1 
HETATM 1738 O O   . HOH C 3 .   ? -2.70838  10.93161 -0.45216  1.000 42.62981 ? 587 HOH A O   1 
HETATM 1739 O O   . HOH C 3 .   ? -0.01237  27.82590 -13.99354 1.000 60.93525 ? 588 HOH A O   1 
HETATM 1740 O O   . HOH C 3 .   ? -1.54538  28.53393 10.11509  1.000 36.05923 ? 589 HOH A O   1 
HETATM 1741 O O   . HOH C 3 .   ? 1.01711   26.91995 -14.56384 1.000 63.94920 ? 590 HOH A O   1 
HETATM 1742 O O   . HOH C 3 .   ? -1.10996  31.01025 8.79752   1.000 40.85619 ? 591 HOH A O   1 
HETATM 1743 O O   . HOH C 3 .   ? 17.37600  19.35449 5.54289   1.000 56.27603 ? 592 HOH A O   1 
# 
