data_9FTS
# 
_entry.id   9FTS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FTS         pdb_00009fts 10.2210/pdb9fts/pdb 
WWPDB D_1292139463 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FTS 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 5 
_pdbx_contact_author.email              daniele.de_sanctis@esrf.fr 
_pdbx_contact_author.name_first         Daniele 
_pdbx_contact_author.name_last          'de Sanctis' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0391-8290 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Orlans, J.'     1 0000-0002-6933-2287 
'Rose, S.L.'     2 0000-0003-4824-4066 
'Basu, S.'       3 0000-0001-6484-8236 
'de Sanctis, D.' 4 0000-0003-0391-8290 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Commun Chem' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2399-3669 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            8 
_citation.language                  ? 
_citation.page_first                6 
_citation.page_last                 6 
_citation.title                     
'Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s42004-024-01404-y 
_citation.pdbx_database_id_PubMed   39775172 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Orlans, J.'        1  ?                   
primary 'Rose, S.L.'        2  0000-0003-4824-4066 
primary 'Ferguson, G.'      3  0000-0003-2551-5994 
primary 'Oscarsson, M.'     4  ?                   
primary 'Homs Puron, A.'    5  ?                   
primary 'Beteva, A.'        6  ?                   
primary 'Debionne, S.'      7  ?                   
primary 'Theveneau, P.'     8  ?                   
primary 'Coquelle, N.'      9  ?                   
primary 'Kieffer, J.'       10 0000-0002-0730-6577 
primary 'Busca, P.'         11 ?                   
primary 'Sinoir, J.'        12 ?                   
primary 'Armijo, V.'        13 0009-0006-3243-8391 
primary 'Lopez Marrero, M.' 14 ?                   
primary 'Felisaz, F.'       15 ?                   
primary 'Papp, G.'          16 0000-0002-5702-843X 
primary 'Gonzalez, H.'      17 ?                   
primary 'Caserotto, H.'     18 ?                   
primary 'Dobias, F.'        19 ?                   
primary 'Gigmes, J.'        20 ?                   
primary 'Lebon, G.'         21 0000-0003-1162-5148 
primary 'Basu, S.'          22 0000-0001-6484-8236 
primary 'de Sanctis, D.'    23 0000-0003-0391-8290 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     nat 'Thaumatin I'        22228.043 1   ? ? ? ? 
2 non-polymer syn 'L(+)-TARTARIC ACID' 150.087   1   ? ? ? ? 
3 water       nat water                18.015    164 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        Thaumatin-1 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'L(+)-TARTARIC ACID' TLA 
3 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   THR n 
1 3   PHE n 
1 4   GLU n 
1 5   ILE n 
1 6   VAL n 
1 7   ASN n 
1 8   ARG n 
1 9   CYS n 
1 10  SER n 
1 11  TYR n 
1 12  THR n 
1 13  VAL n 
1 14  TRP n 
1 15  ALA n 
1 16  ALA n 
1 17  ALA n 
1 18  SER n 
1 19  LYS n 
1 20  GLY n 
1 21  ASP n 
1 22  ALA n 
1 23  ALA n 
1 24  LEU n 
1 25  ASP n 
1 26  ALA n 
1 27  GLY n 
1 28  GLY n 
1 29  ARG n 
1 30  GLN n 
1 31  LEU n 
1 32  ASN n 
1 33  SER n 
1 34  GLY n 
1 35  GLU n 
1 36  SER n 
1 37  TRP n 
1 38  THR n 
1 39  ILE n 
1 40  ASN n 
1 41  VAL n 
1 42  GLU n 
1 43  PRO n 
1 44  GLY n 
1 45  THR n 
1 46  ASN n 
1 47  GLY n 
1 48  GLY n 
1 49  LYS n 
1 50  ILE n 
1 51  TRP n 
1 52  ALA n 
1 53  ARG n 
1 54  THR n 
1 55  ASP n 
1 56  CYS n 
1 57  TYR n 
1 58  PHE n 
1 59  ASP n 
1 60  ASP n 
1 61  SER n 
1 62  GLY n 
1 63  SER n 
1 64  GLY n 
1 65  ILE n 
1 66  CYS n 
1 67  LYS n 
1 68  THR n 
1 69  GLY n 
1 70  ASP n 
1 71  CYS n 
1 72  GLY n 
1 73  GLY n 
1 74  LEU n 
1 75  LEU n 
1 76  ARG n 
1 77  CYS n 
1 78  LYS n 
1 79  ARG n 
1 80  PHE n 
1 81  GLY n 
1 82  ARG n 
1 83  PRO n 
1 84  PRO n 
1 85  THR n 
1 86  THR n 
1 87  LEU n 
1 88  ALA n 
1 89  GLU n 
1 90  PHE n 
1 91  SER n 
1 92  LEU n 
1 93  ASN n 
1 94  GLN n 
1 95  TYR n 
1 96  GLY n 
1 97  LYS n 
1 98  ASP n 
1 99  TYR n 
1 100 ILE n 
1 101 ASP n 
1 102 ILE n 
1 103 SER n 
1 104 ASN n 
1 105 ILE n 
1 106 LYS n 
1 107 GLY n 
1 108 PHE n 
1 109 ASN n 
1 110 VAL n 
1 111 PRO n 
1 112 MET n 
1 113 ASP n 
1 114 PHE n 
1 115 SER n 
1 116 PRO n 
1 117 THR n 
1 118 THR n 
1 119 ARG n 
1 120 GLY n 
1 121 CYS n 
1 122 ARG n 
1 123 GLY n 
1 124 VAL n 
1 125 ARG n 
1 126 CYS n 
1 127 ALA n 
1 128 ALA n 
1 129 ASP n 
1 130 ILE n 
1 131 VAL n 
1 132 GLY n 
1 133 GLN n 
1 134 CYS n 
1 135 PRO n 
1 136 ALA n 
1 137 LYS n 
1 138 LEU n 
1 139 LYS n 
1 140 ALA n 
1 141 PRO n 
1 142 GLY n 
1 143 GLY n 
1 144 GLY n 
1 145 CYS n 
1 146 ASN n 
1 147 ASP n 
1 148 ALA n 
1 149 CYS n 
1 150 THR n 
1 151 VAL n 
1 152 PHE n 
1 153 GLN n 
1 154 THR n 
1 155 SER n 
1 156 GLU n 
1 157 TYR n 
1 158 CYS n 
1 159 CYS n 
1 160 THR n 
1 161 THR n 
1 162 GLY n 
1 163 LYS n 
1 164 CYS n 
1 165 GLY n 
1 166 PRO n 
1 167 THR n 
1 168 GLU n 
1 169 TYR n 
1 170 SER n 
1 171 ARG n 
1 172 PHE n 
1 173 PHE n 
1 174 LYS n 
1 175 ARG n 
1 176 LEU n 
1 177 CYS n 
1 178 PRO n 
1 179 ASP n 
1 180 ALA n 
1 181 PHE n 
1 182 SER n 
1 183 TYR n 
1 184 VAL n 
1 185 LEU n 
1 186 ASP n 
1 187 LYS n 
1 188 PRO n 
1 189 THR n 
1 190 THR n 
1 191 VAL n 
1 192 THR n 
1 193 CYS n 
1 194 PRO n 
1 195 GLY n 
1 196 SER n 
1 197 SER n 
1 198 ASN n 
1 199 TYR n 
1 200 ARG n 
1 201 VAL n 
1 202 THR n 
1 203 PHE n 
1 204 CYS n 
1 205 PRO n 
1 206 THR n 
1 207 ALA n 
# 
_entity_src_nat.entity_id                  1 
_entity_src_nat.pdbx_src_id                1 
_entity_src_nat.pdbx_alt_source_flag       sample 
_entity_src_nat.pdbx_beg_seq_num           1 
_entity_src_nat.pdbx_end_seq_num           207 
_entity_src_nat.common_name                ? 
_entity_src_nat.pdbx_organism_scientific   'Thaumatococcus daniellii' 
_entity_src_nat.pdbx_ncbi_taxonomy_id      4621 
_entity_src_nat.genus                      ? 
_entity_src_nat.species                    ? 
_entity_src_nat.strain                     ? 
_entity_src_nat.tissue                     ? 
_entity_src_nat.tissue_fraction            ? 
_entity_src_nat.pdbx_secretion             ? 
_entity_src_nat.pdbx_fragment              ? 
_entity_src_nat.pdbx_variant               ? 
_entity_src_nat.pdbx_cell_line             ? 
_entity_src_nat.pdbx_atcc                  ? 
_entity_src_nat.pdbx_cellular_location     ? 
_entity_src_nat.pdbx_organ                 ? 
_entity_src_nat.pdbx_organelle             ? 
_entity_src_nat.pdbx_cell                  ? 
_entity_src_nat.pdbx_plasmid_name          ? 
_entity_src_nat.pdbx_plasmid_details       ? 
_entity_src_nat.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'     75.067  
HOH non-polymer         . WATER                ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'     119.119 
TLA non-polymer         . 'L(+)-TARTARIC ACID' ? 'C4 H6 O6'       150.087 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   1   ALA ALA A . n 
A 1 2   THR 2   2   2   THR THR A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   ASN 7   7   7   ASN ASN A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   CYS 9   9   9   CYS CYS A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  TYR 11  11  11  TYR TYR A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  TRP 14  14  14  TRP TRP A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  LYS 19  19  19  LYS LYS A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  ALA 23  23  23  ALA ALA A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  GLY 28  28  28  GLY GLY A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ASN 32  32  32  ASN ASN A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  TRP 37  37  37  TRP TRP A . n 
A 1 38  THR 38  38  38  THR THR A . n 
A 1 39  ILE 39  39  39  ILE ILE A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  PRO 43  43  43  PRO PRO A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  GLY 47  47  47  GLY GLY A . n 
A 1 48  GLY 48  48  48  GLY GLY A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  TRP 51  51  51  TRP TRP A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  CYS 56  56  56  CYS CYS A . n 
A 1 57  TYR 57  57  57  TYR TYR A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASP 59  59  59  ASP ASP A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLY 62  62  62  GLY GLY A . n 
A 1 63  SER 63  63  63  SER SER A . n 
A 1 64  GLY 64  64  64  GLY GLY A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  CYS 66  66  66  CYS CYS A . n 
A 1 67  LYS 67  67  67  LYS LYS A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  ASP 70  70  70  ASP ASP A . n 
A 1 71  CYS 71  71  71  CYS CYS A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  CYS 77  77  77  CYS CYS A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  ARG 82  82  82  ARG ARG A . n 
A 1 83  PRO 83  83  83  PRO PRO A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  THR 86  86  86  THR THR A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  PHE 90  90  90  PHE PHE A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  GLN 94  94  94  GLN GLN A . n 
A 1 95  TYR 95  95  95  TYR TYR A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  TYR 99  99  99  TYR TYR A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 ILE 102 102 102 ILE ILE A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 ASN 104 104 104 ASN ASN A . n 
A 1 105 ILE 105 105 105 ILE ILE A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 ASN 109 109 109 ASN ASN A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 PRO 111 111 111 PRO PRO A . n 
A 1 112 MET 112 112 112 MET MET A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 PHE 114 114 114 PHE PHE A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 PRO 116 116 116 PRO PRO A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 CYS 121 121 121 CYS CYS A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 CYS 126 126 126 CYS CYS A . n 
A 1 127 ALA 127 127 127 ALA ALA A . n 
A 1 128 ALA 128 128 128 ALA ALA A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 VAL 131 131 131 VAL VAL A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 CYS 134 134 134 CYS CYS A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 PRO 141 141 141 PRO PRO A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASP 147 147 147 ASP ASP A . n 
A 1 148 ALA 148 148 148 ALA ALA A . n 
A 1 149 CYS 149 149 149 CYS CYS A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 THR 154 154 154 THR THR A . n 
A 1 155 SER 155 155 155 SER SER A . n 
A 1 156 GLU 156 156 156 GLU GLU A . n 
A 1 157 TYR 157 157 157 TYR TYR A . n 
A 1 158 CYS 158 158 158 CYS CYS A . n 
A 1 159 CYS 159 159 159 CYS CYS A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 THR 161 161 161 THR THR A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 LYS 163 163 163 LYS LYS A . n 
A 1 164 CYS 164 164 164 CYS CYS A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 PRO 166 166 166 PRO PRO A . n 
A 1 167 THR 167 167 167 THR THR A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 PHE 173 173 173 PHE PHE A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 ARG 175 175 175 ARG ARG A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 CYS 177 177 177 CYS CYS A . n 
A 1 178 PRO 178 178 178 PRO PRO A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 TYR 183 183 183 TYR TYR A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 LYS 187 187 187 LYS LYS A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ASN 198 198 198 ASN ASN A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 ARG 200 200 200 ARG ARG A . n 
A 1 201 VAL 201 201 201 VAL VAL A . n 
A 1 202 THR 202 202 202 THR THR A . n 
A 1 203 PHE 203 203 203 PHE PHE A . n 
A 1 204 CYS 204 204 204 CYS CYS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 THR 206 206 206 THR THR A . n 
A 1 207 ALA 207 207 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 TLA 1   301 301 TLA TLA A . 
C 3 HOH 1   401 339 HOH HOH A . 
C 3 HOH 2   402 350 HOH HOH A . 
C 3 HOH 3   403 96  HOH HOH A . 
C 3 HOH 4   404 129 HOH HOH A . 
C 3 HOH 5   405 190 HOH HOH A . 
C 3 HOH 6   406 43  HOH HOH A . 
C 3 HOH 7   407 37  HOH HOH A . 
C 3 HOH 8   408 14  HOH HOH A . 
C 3 HOH 9   409 10  HOH HOH A . 
C 3 HOH 10  410 425 HOH HOH A . 
C 3 HOH 11  411 128 HOH HOH A . 
C 3 HOH 12  412 169 HOH HOH A . 
C 3 HOH 13  413 117 HOH HOH A . 
C 3 HOH 14  414 120 HOH HOH A . 
C 3 HOH 15  415 35  HOH HOH A . 
C 3 HOH 16  416 181 HOH HOH A . 
C 3 HOH 17  417 12  HOH HOH A . 
C 3 HOH 18  418 113 HOH HOH A . 
C 3 HOH 19  419 28  HOH HOH A . 
C 3 HOH 20  420 9   HOH HOH A . 
C 3 HOH 21  421 373 HOH HOH A . 
C 3 HOH 22  422 158 HOH HOH A . 
C 3 HOH 23  423 59  HOH HOH A . 
C 3 HOH 24  424 67  HOH HOH A . 
C 3 HOH 25  425 64  HOH HOH A . 
C 3 HOH 26  426 4   HOH HOH A . 
C 3 HOH 27  427 52  HOH HOH A . 
C 3 HOH 28  428 89  HOH HOH A . 
C 3 HOH 29  429 133 HOH HOH A . 
C 3 HOH 30  430 16  HOH HOH A . 
C 3 HOH 31  431 23  HOH HOH A . 
C 3 HOH 32  432 336 HOH HOH A . 
C 3 HOH 33  433 68  HOH HOH A . 
C 3 HOH 34  434 119 HOH HOH A . 
C 3 HOH 35  435 56  HOH HOH A . 
C 3 HOH 36  436 279 HOH HOH A . 
C 3 HOH 37  437 39  HOH HOH A . 
C 3 HOH 38  438 97  HOH HOH A . 
C 3 HOH 39  439 22  HOH HOH A . 
C 3 HOH 40  440 57  HOH HOH A . 
C 3 HOH 41  441 7   HOH HOH A . 
C 3 HOH 42  442 2   HOH HOH A . 
C 3 HOH 43  443 25  HOH HOH A . 
C 3 HOH 44  444 100 HOH HOH A . 
C 3 HOH 45  445 17  HOH HOH A . 
C 3 HOH 46  446 24  HOH HOH A . 
C 3 HOH 47  447 341 HOH HOH A . 
C 3 HOH 48  448 63  HOH HOH A . 
C 3 HOH 49  449 111 HOH HOH A . 
C 3 HOH 50  450 19  HOH HOH A . 
C 3 HOH 51  451 159 HOH HOH A . 
C 3 HOH 52  452 3   HOH HOH A . 
C 3 HOH 53  453 414 HOH HOH A . 
C 3 HOH 54  454 77  HOH HOH A . 
C 3 HOH 55  455 74  HOH HOH A . 
C 3 HOH 56  456 94  HOH HOH A . 
C 3 HOH 57  457 11  HOH HOH A . 
C 3 HOH 58  458 186 HOH HOH A . 
C 3 HOH 59  459 5   HOH HOH A . 
C 3 HOH 60  460 47  HOH HOH A . 
C 3 HOH 61  461 265 HOH HOH A . 
C 3 HOH 62  462 20  HOH HOH A . 
C 3 HOH 63  463 135 HOH HOH A . 
C 3 HOH 64  464 15  HOH HOH A . 
C 3 HOH 65  465 66  HOH HOH A . 
C 3 HOH 66  466 73  HOH HOH A . 
C 3 HOH 67  467 76  HOH HOH A . 
C 3 HOH 68  468 58  HOH HOH A . 
C 3 HOH 69  469 34  HOH HOH A . 
C 3 HOH 70  470 81  HOH HOH A . 
C 3 HOH 71  471 30  HOH HOH A . 
C 3 HOH 72  472 109 HOH HOH A . 
C 3 HOH 73  473 44  HOH HOH A . 
C 3 HOH 74  474 27  HOH HOH A . 
C 3 HOH 75  475 93  HOH HOH A . 
C 3 HOH 76  476 61  HOH HOH A . 
C 3 HOH 77  477 166 HOH HOH A . 
C 3 HOH 78  478 60  HOH HOH A . 
C 3 HOH 79  479 21  HOH HOH A . 
C 3 HOH 80  480 70  HOH HOH A . 
C 3 HOH 81  481 29  HOH HOH A . 
C 3 HOH 82  482 455 HOH HOH A . 
C 3 HOH 83  483 112 HOH HOH A . 
C 3 HOH 84  484 105 HOH HOH A . 
C 3 HOH 85  485 170 HOH HOH A . 
C 3 HOH 86  486 13  HOH HOH A . 
C 3 HOH 87  487 104 HOH HOH A . 
C 3 HOH 88  488 99  HOH HOH A . 
C 3 HOH 89  489 40  HOH HOH A . 
C 3 HOH 90  490 6   HOH HOH A . 
C 3 HOH 91  491 141 HOH HOH A . 
C 3 HOH 92  492 78  HOH HOH A . 
C 3 HOH 93  493 41  HOH HOH A . 
C 3 HOH 94  494 150 HOH HOH A . 
C 3 HOH 95  495 330 HOH HOH A . 
C 3 HOH 96  496 38  HOH HOH A . 
C 3 HOH 97  497 48  HOH HOH A . 
C 3 HOH 98  498 1   HOH HOH A . 
C 3 HOH 99  499 65  HOH HOH A . 
C 3 HOH 100 500 46  HOH HOH A . 
C 3 HOH 101 501 418 HOH HOH A . 
C 3 HOH 102 502 121 HOH HOH A . 
C 3 HOH 103 503 71  HOH HOH A . 
C 3 HOH 104 504 55  HOH HOH A . 
C 3 HOH 105 505 18  HOH HOH A . 
C 3 HOH 106 506 36  HOH HOH A . 
C 3 HOH 107 507 69  HOH HOH A . 
C 3 HOH 108 508 31  HOH HOH A . 
C 3 HOH 109 509 165 HOH HOH A . 
C 3 HOH 110 510 372 HOH HOH A . 
C 3 HOH 111 511 110 HOH HOH A . 
C 3 HOH 112 512 108 HOH HOH A . 
C 3 HOH 113 513 136 HOH HOH A . 
C 3 HOH 114 514 33  HOH HOH A . 
C 3 HOH 115 515 26  HOH HOH A . 
C 3 HOH 116 516 53  HOH HOH A . 
C 3 HOH 117 517 75  HOH HOH A . 
C 3 HOH 118 518 62  HOH HOH A . 
C 3 HOH 119 519 54  HOH HOH A . 
C 3 HOH 120 520 42  HOH HOH A . 
C 3 HOH 121 521 337 HOH HOH A . 
C 3 HOH 122 522 8   HOH HOH A . 
C 3 HOH 123 523 45  HOH HOH A . 
C 3 HOH 124 524 114 HOH HOH A . 
C 3 HOH 125 525 240 HOH HOH A . 
C 3 HOH 126 526 98  HOH HOH A . 
C 3 HOH 127 527 157 HOH HOH A . 
C 3 HOH 128 528 142 HOH HOH A . 
C 3 HOH 129 529 134 HOH HOH A . 
C 3 HOH 130 530 82  HOH HOH A . 
C 3 HOH 131 531 84  HOH HOH A . 
C 3 HOH 132 532 51  HOH HOH A . 
C 3 HOH 133 533 87  HOH HOH A . 
C 3 HOH 134 534 153 HOH HOH A . 
C 3 HOH 135 535 50  HOH HOH A . 
C 3 HOH 136 536 257 HOH HOH A . 
C 3 HOH 137 537 233 HOH HOH A . 
C 3 HOH 138 538 72  HOH HOH A . 
C 3 HOH 139 539 223 HOH HOH A . 
C 3 HOH 140 540 219 HOH HOH A . 
C 3 HOH 141 541 146 HOH HOH A . 
C 3 HOH 142 542 116 HOH HOH A . 
C 3 HOH 143 543 411 HOH HOH A . 
C 3 HOH 144 544 137 HOH HOH A . 
C 3 HOH 145 545 148 HOH HOH A . 
C 3 HOH 146 546 32  HOH HOH A . 
C 3 HOH 147 547 232 HOH HOH A . 
C 3 HOH 148 548 80  HOH HOH A . 
C 3 HOH 149 549 95  HOH HOH A . 
C 3 HOH 150 550 224 HOH HOH A . 
C 3 HOH 151 551 297 HOH HOH A . 
C 3 HOH 152 552 287 HOH HOH A . 
C 3 HOH 153 553 296 HOH HOH A . 
C 3 HOH 154 554 125 HOH HOH A . 
C 3 HOH 155 555 415 HOH HOH A . 
C 3 HOH 156 556 123 HOH HOH A . 
C 3 HOH 157 557 131 HOH HOH A . 
C 3 HOH 158 558 107 HOH HOH A . 
C 3 HOH 159 559 492 HOH HOH A . 
C 3 HOH 160 560 91  HOH HOH A . 
C 3 HOH 161 561 92  HOH HOH A . 
C 3 HOH 162 562 447 HOH HOH A . 
C 3 HOH 163 563 396 HOH HOH A . 
C 3 HOH 164 564 118 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 78  ? CG  ? A LYS 78  CG  
2  1 Y 1 A LYS 78  ? CD  ? A LYS 78  CD  
3  1 Y 1 A LYS 78  ? CE  ? A LYS 78  CE  
4  1 Y 1 A LYS 78  ? NZ  ? A LYS 78  NZ  
5  1 Y 1 A ARG 79  ? CG  ? A ARG 79  CG  
6  1 Y 1 A ARG 79  ? CD  ? A ARG 79  CD  
7  1 Y 1 A ARG 79  ? NE  ? A ARG 79  NE  
8  1 Y 1 A ARG 79  ? CZ  ? A ARG 79  CZ  
9  1 Y 1 A ARG 79  ? NH1 ? A ARG 79  NH1 
10 1 Y 1 A ARG 79  ? NH2 ? A ARG 79  NH2 
11 1 Y 1 A ARG 119 ? CG  ? A ARG 119 CG  
12 1 Y 1 A ARG 119 ? CD  ? A ARG 119 CD  
13 1 Y 1 A ARG 119 ? NE  ? A ARG 119 NE  
14 1 Y 1 A ARG 119 ? CZ  ? A ARG 119 CZ  
15 1 Y 1 A ARG 119 ? NH1 ? A ARG 119 NH1 
16 1 Y 1 A ARG 119 ? NH2 ? A ARG 119 NH2 
17 1 Y 1 A LYS 163 ? CG  ? A LYS 163 CG  
18 1 Y 1 A LYS 163 ? CD  ? A LYS 163 CD  
19 1 Y 1 A LYS 163 ? CE  ? A LYS 163 CE  
20 1 Y 1 A LYS 163 ? NZ  ? A LYS 163 NZ  
21 1 Y 1 A LYS 187 ? CG  ? A LYS 187 CG  
22 1 Y 1 A LYS 187 ? CD  ? A LYS 187 CD  
23 1 Y 1 A LYS 187 ? CE  ? A LYS 187 CE  
24 1 Y 1 A LYS 187 ? NZ  ? A LYS 187 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FTS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.480 
_cell.length_a_esd                 ? 
_cell.length_b                     58.480 
_cell.length_b_esd                 ? 
_cell.length_c                     151.350 
_cell.length_c_esd                 ? 
_cell.volume                       517603.439 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FTS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                92 
_symmetry.space_group_name_Hall            'P 4abw 2nw' 
_symmetry.space_group_name_H-M             'P 41 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FTS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.91 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES pH 7.5, 1.8 M Sodium Potassium Tartrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'PSI JUNGFRAU 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.072 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID29' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.072 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID29 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          22.00 
_reflns.entry_id                                       9FTS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               58.48 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     27498 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                595 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.29 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   0.9958 
_reflns.pdbx_R_split                                   0.183 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.78 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1269 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  0.5698 
_reflns_shell.pdbx_R_split                                  1.774 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.13 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FTS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             54.55 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27333 
_refine.ls_number_reflns_R_free                  1996 
_refine.ls_number_reflns_R_work                  25337 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.70 
_refine.ls_percent_reflns_R_free                 7.30 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1538 
_refine.ls_R_factor_R_free                       0.1816 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1516 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.6901 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2224 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        54.55 
_refine_hist.number_atoms_solvent             164 
_refine_hist.number_atoms_total               1695 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1521 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0139  ? 1594 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2615  ? 2176 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0844  ? 239  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0141  ? 289  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.3653 ? 565  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.79  . . 135 1701 95.82  . . . . 0.3749 . . . . . . . . . . . 0.3996 
'X-RAY DIFFRACTION' 1.79 1.84  . . 142 1781 99.95  . . . . 0.2998 . . . . . . . . . . . 0.3295 
'X-RAY DIFFRACTION' 1.84 1.90  . . 139 1778 100.00 . . . . 0.2431 . . . . . . . . . . . 0.2824 
'X-RAY DIFFRACTION' 1.90 1.96  . . 140 1779 100.00 . . . . 0.2057 . . . . . . . . . . . 0.2283 
'X-RAY DIFFRACTION' 1.96 2.03  . . 140 1778 100.00 . . . . 0.2011 . . . . . . . . . . . 0.2293 
'X-RAY DIFFRACTION' 2.03 2.11  . . 140 1782 100.00 . . . . 0.1513 . . . . . . . . . . . 0.2002 
'X-RAY DIFFRACTION' 2.11 2.20  . . 140 1776 100.00 . . . . 0.1421 . . . . . . . . . . . 0.1843 
'X-RAY DIFFRACTION' 2.21 2.32  . . 142 1808 100.00 . . . . 0.1393 . . . . . . . . . . . 0.1639 
'X-RAY DIFFRACTION' 2.32 2.47  . . 142 1810 100.00 . . . . 0.1430 . . . . . . . . . . . 0.1830 
'X-RAY DIFFRACTION' 2.47 2.66  . . 143 1813 100.00 . . . . 0.1543 . . . . . . . . . . . 0.1906 
'X-RAY DIFFRACTION' 2.66 2.92  . . 144 1815 100.00 . . . . 0.1538 . . . . . . . . . . . 0.1883 
'X-RAY DIFFRACTION' 2.93 3.35  . . 143 1835 100.00 . . . . 0.1503 . . . . . . . . . . . 0.1730 
'X-RAY DIFFRACTION' 3.35 4.22  . . 149 1882 99.95  . . . . 0.1150 . . . . . . . . . . . 0.1442 
'X-RAY DIFFRACTION' 4.22 54.55 . . 157 1999 99.95  . . . . 0.1145 . . . . . . . . . . . 0.1322 
# 
_struct.entry_id                     9FTS 
_struct.title                        'Serial microseconds crystallography at ID29 using SACLA extruder: Thaumatin' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FTS 
_struct_keywords.text            
'Serial Crystallography, serial microsecond crystallography, ID29, room temperature, ESRF-EBS, PLANT PROTEIN' 
_struct_keywords.pdbx_keywords   'PLANT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    THM1_THADA 
_struct_ref.pdbx_db_accession          P02883 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRF
GRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCT
TGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA
;
_struct_ref.pdbx_align_begin           23 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FTS 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 207 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P02883 
_struct_ref_seq.db_align_beg                  23 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  229 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       207 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASP A 129 ? CYS A 134 ? ASP A 129 CYS A 134 1 ? 6  
HELX_P HELX_P2 AA2 PRO A 135 ? LYS A 139 ? PRO A 135 LYS A 139 5 ? 5  
HELX_P HELX_P3 AA3 ASP A 147 ? GLN A 153 ? ASP A 147 GLN A 153 1 ? 7  
HELX_P HELX_P4 AA4 THR A 154 ? CYS A 159 ? THR A 154 CYS A 159 1 ? 6  
HELX_P HELX_P5 AA5 THR A 167 ? CYS A 177 ? THR A 167 CYS A 177 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 9   SG ? ? ? 1_555 A CYS 204 SG ? ? A CYS 9   A CYS 204 1_555 ? ? ? ? ? ? ? 2.006 ? ? 
disulf2 disulf ? ? A CYS 56  SG ? ? ? 1_555 A CYS 66  SG ? ? A CYS 56  A CYS 66  1_555 ? ? ? ? ? ? ? 2.024 ? ? 
disulf3 disulf ? ? A CYS 71  SG ? ? ? 1_555 A CYS 77  SG ? ? A CYS 71  A CYS 77  1_555 ? ? ? ? ? ? ? 2.016 ? ? 
disulf4 disulf ? ? A CYS 121 SG ? ? ? 1_555 A CYS 193 SG ? ? A CYS 121 A CYS 193 1_555 ? ? ? ? ? ? ? 2.038 ? ? 
disulf5 disulf ? ? A CYS 126 SG ? ? ? 1_555 A CYS 177 SG ? ? A CYS 126 A CYS 177 1_555 ? ? ? ? ? ? ? 2.010 ? ? 
disulf6 disulf ? ? A CYS 134 SG ? ? ? 1_555 A CYS 145 SG ? ? A CYS 134 A CYS 145 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
disulf7 disulf ? ? A CYS 149 SG ? ? ? 1_555 A CYS 158 SG ? ? A CYS 149 A CYS 158 1_555 ? ? ? ? ? ? ? 2.064 ? ? 
disulf8 disulf ? ? A CYS 159 SG A ? ? 1_555 A CYS 164 SG ? ? A CYS 159 A CYS 164 1_555 ? ? ? ? ? ? ? 2.028 ? ? 
disulf9 disulf ? ? A CYS 159 SG B ? ? 1_555 A CYS 164 SG ? ? A CYS 159 A CYS 164 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 9   ? CYS A 204 ? CYS A 9   ? 1_555 CYS A 204 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 56  ? CYS A 66  ? CYS A 56  ? 1_555 CYS A 66  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 71  ? CYS A 77  ? CYS A 71  ? 1_555 CYS A 77  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 121 ? CYS A 193 ? CYS A 121 ? 1_555 CYS A 193 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 126 ? CYS A 177 ? CYS A 126 ? 1_555 CYS A 177 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS A 134 ? CYS A 145 ? CYS A 134 ? 1_555 CYS A 145 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS A 149 ? CYS A 158 ? CYS A 149 ? 1_555 CYS A 158 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS A 159 A CYS A 164 ? CYS A 159 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
9 CYS A 159 B CYS A 164 ? CYS A 159 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PRO 
_struct_mon_prot_cis.label_seq_id           83 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PRO 
_struct_mon_prot_cis.auth_seq_id            83 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    84 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     84 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       4.07 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 6 ? 
AA3 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 36  ? ASN A 40  ? SER A 36  ASN A 40  
AA1 2 THR A 2   ? ASN A 7   ? THR A 2   ASN A 7   
AA1 3 TYR A 199 ? PHE A 203 ? TYR A 199 PHE A 203 
AA1 4 MET A 112 ? PRO A 116 ? MET A 112 PRO A 116 
AA1 5 VAL A 124 ? CYS A 126 ? VAL A 124 CYS A 126 
AA2 1 ALA A 23  ? LEU A 31  ? ALA A 23  LEU A 31  
AA2 2 VAL A 13  ? SER A 18  ? VAL A 13  SER A 18  
AA2 3 GLY A 48  ? PHE A 58  ? GLY A 48  PHE A 58  
AA2 4 LEU A 87  ? GLN A 94  ? LEU A 87  GLN A 94  
AA2 5 LYS A 97  ? SER A 103 ? LYS A 97  SER A 103 
AA2 6 ALA A 180 ? PHE A 181 ? ALA A 180 PHE A 181 
AA3 1 GLY A 64  ? THR A 68  ? GLY A 64  THR A 68  
AA3 2 GLY A 48  ? PHE A 58  ? GLY A 48  PHE A 58  
AA3 3 LEU A 87  ? GLN A 94  ? LEU A 87  GLN A 94  
AA3 4 LYS A 97  ? SER A 103 ? LYS A 97  SER A 103 
AA3 5 VAL A 191 ? PRO A 194 ? VAL A 191 PRO A 194 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TRP A 37  ? O TRP A 37  N ILE A 5   ? N ILE A 5   
AA1 2 3 N VAL A 6   ? N VAL A 6   O VAL A 201 ? O VAL A 201 
AA1 3 4 O ARG A 200 ? O ARG A 200 N SER A 115 ? N SER A 115 
AA1 4 5 N PHE A 114 ? N PHE A 114 O VAL A 124 ? O VAL A 124 
AA2 1 2 O LEU A 31  ? O LEU A 31  N VAL A 13  ? N VAL A 13  
AA2 2 3 N SER A 18  ? N SER A 18  O LYS A 49  ? O LYS A 49  
AA2 3 4 N ILE A 50  ? N ILE A 50  O ALA A 88  ? O ALA A 88  
AA2 4 5 N GLN A 94  ? N GLN A 94  O LYS A 97  ? O LYS A 97  
AA2 5 6 N ILE A 102 ? N ILE A 102 O PHE A 181 ? O PHE A 181 
AA3 1 2 O ILE A 65  ? O ILE A 65  N TYR A 57  ? N TYR A 57  
AA3 2 3 N ILE A 50  ? N ILE A 50  O ALA A 88  ? O ALA A 88  
AA3 3 4 N GLN A 94  ? N GLN A 94  O LYS A 97  ? O LYS A 97  
AA3 4 5 N ILE A 100 ? N ILE A 100 O VAL A 191 ? O VAL A 191 
# 
_pdbx_entry_details.entry_id                   9FTS 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 NZ  A LYS 139 ? ? O A HOH 401 ? ? 1.83 
2 1 O   A HOH 511 ? ? O A HOH 524 ? ? 1.87 
3 1 O   A HOH 418 ? ? O A HOH 421 ? ? 1.92 
4 1 NH2 A ARG 122 ? ? O A HOH 402 ? ? 1.96 
5 1 O   A HOH 483 ? ? O A HOH 550 ? ? 1.99 
6 1 O   A HOH 475 ? ? O A HOH 543 ? ? 2.10 
7 1 O   A HOH 466 ? ? O A HOH 512 ? ? 2.15 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 25 ? ? 53.80   -136.83 
2 1 CYS A 71 ? ? -113.18 71.26   
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     76 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.082 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+1/4  
3 y+1/2,-x+1/2,z+3/4  
4 x+1/2,-y+1/2,-z+3/4 
5 -x+1/2,y+1/2,-z+1/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     ALA 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      207 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    ALA 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     207 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HOH O    O N N 137 
HOH H1   H N N 138 
HOH H2   H N N 139 
ILE N    N N N 140 
ILE CA   C N S 141 
ILE C    C N N 142 
ILE O    O N N 143 
ILE CB   C N S 144 
ILE CG1  C N N 145 
ILE CG2  C N N 146 
ILE CD1  C N N 147 
ILE OXT  O N N 148 
ILE H    H N N 149 
ILE H2   H N N 150 
ILE HA   H N N 151 
ILE HB   H N N 152 
ILE HG12 H N N 153 
ILE HG13 H N N 154 
ILE HG21 H N N 155 
ILE HG22 H N N 156 
ILE HG23 H N N 157 
ILE HD11 H N N 158 
ILE HD12 H N N 159 
ILE HD13 H N N 160 
ILE HXT  H N N 161 
LEU N    N N N 162 
LEU CA   C N S 163 
LEU C    C N N 164 
LEU O    O N N 165 
LEU CB   C N N 166 
LEU CG   C N N 167 
LEU CD1  C N N 168 
LEU CD2  C N N 169 
LEU OXT  O N N 170 
LEU H    H N N 171 
LEU H2   H N N 172 
LEU HA   H N N 173 
LEU HB2  H N N 174 
LEU HB3  H N N 175 
LEU HG   H N N 176 
LEU HD11 H N N 177 
LEU HD12 H N N 178 
LEU HD13 H N N 179 
LEU HD21 H N N 180 
LEU HD22 H N N 181 
LEU HD23 H N N 182 
LEU HXT  H N N 183 
LYS N    N N N 184 
LYS CA   C N S 185 
LYS C    C N N 186 
LYS O    O N N 187 
LYS CB   C N N 188 
LYS CG   C N N 189 
LYS CD   C N N 190 
LYS CE   C N N 191 
LYS NZ   N N N 192 
LYS OXT  O N N 193 
LYS H    H N N 194 
LYS H2   H N N 195 
LYS HA   H N N 196 
LYS HB2  H N N 197 
LYS HB3  H N N 198 
LYS HG2  H N N 199 
LYS HG3  H N N 200 
LYS HD2  H N N 201 
LYS HD3  H N N 202 
LYS HE2  H N N 203 
LYS HE3  H N N 204 
LYS HZ1  H N N 205 
LYS HZ2  H N N 206 
LYS HZ3  H N N 207 
LYS HXT  H N N 208 
MET N    N N N 209 
MET CA   C N S 210 
MET C    C N N 211 
MET O    O N N 212 
MET CB   C N N 213 
MET CG   C N N 214 
MET SD   S N N 215 
MET CE   C N N 216 
MET OXT  O N N 217 
MET H    H N N 218 
MET H2   H N N 219 
MET HA   H N N 220 
MET HB2  H N N 221 
MET HB3  H N N 222 
MET HG2  H N N 223 
MET HG3  H N N 224 
MET HE1  H N N 225 
MET HE2  H N N 226 
MET HE3  H N N 227 
MET HXT  H N N 228 
PHE N    N N N 229 
PHE CA   C N S 230 
PHE C    C N N 231 
PHE O    O N N 232 
PHE CB   C N N 233 
PHE CG   C Y N 234 
PHE CD1  C Y N 235 
PHE CD2  C Y N 236 
PHE CE1  C Y N 237 
PHE CE2  C Y N 238 
PHE CZ   C Y N 239 
PHE OXT  O N N 240 
PHE H    H N N 241 
PHE H2   H N N 242 
PHE HA   H N N 243 
PHE HB2  H N N 244 
PHE HB3  H N N 245 
PHE HD1  H N N 246 
PHE HD2  H N N 247 
PHE HE1  H N N 248 
PHE HE2  H N N 249 
PHE HZ   H N N 250 
PHE HXT  H N N 251 
PRO N    N N N 252 
PRO CA   C N S 253 
PRO C    C N N 254 
PRO O    O N N 255 
PRO CB   C N N 256 
PRO CG   C N N 257 
PRO CD   C N N 258 
PRO OXT  O N N 259 
PRO H    H N N 260 
PRO HA   H N N 261 
PRO HB2  H N N 262 
PRO HB3  H N N 263 
PRO HG2  H N N 264 
PRO HG3  H N N 265 
PRO HD2  H N N 266 
PRO HD3  H N N 267 
PRO HXT  H N N 268 
SER N    N N N 269 
SER CA   C N S 270 
SER C    C N N 271 
SER O    O N N 272 
SER CB   C N N 273 
SER OG   O N N 274 
SER OXT  O N N 275 
SER H    H N N 276 
SER H2   H N N 277 
SER HA   H N N 278 
SER HB2  H N N 279 
SER HB3  H N N 280 
SER HG   H N N 281 
SER HXT  H N N 282 
THR N    N N N 283 
THR CA   C N S 284 
THR C    C N N 285 
THR O    O N N 286 
THR CB   C N R 287 
THR OG1  O N N 288 
THR CG2  C N N 289 
THR OXT  O N N 290 
THR H    H N N 291 
THR H2   H N N 292 
THR HA   H N N 293 
THR HB   H N N 294 
THR HG1  H N N 295 
THR HG21 H N N 296 
THR HG22 H N N 297 
THR HG23 H N N 298 
THR HXT  H N N 299 
TLA O1   O N N 300 
TLA O11  O N N 301 
TLA C1   C N N 302 
TLA C2   C N R 303 
TLA O2   O N N 304 
TLA C3   C N R 305 
TLA O3   O N N 306 
TLA C4   C N N 307 
TLA O4   O N N 308 
TLA O41  O N N 309 
TLA H11  H N N 310 
TLA H2   H N N 311 
TLA HA   H N N 312 
TLA H3   H N N 313 
TLA HB   H N N 314 
TLA H41  H N N 315 
TRP N    N N N 316 
TRP CA   C N S 317 
TRP C    C N N 318 
TRP O    O N N 319 
TRP CB   C N N 320 
TRP CG   C Y N 321 
TRP CD1  C Y N 322 
TRP CD2  C Y N 323 
TRP NE1  N Y N 324 
TRP CE2  C Y N 325 
TRP CE3  C Y N 326 
TRP CZ2  C Y N 327 
TRP CZ3  C Y N 328 
TRP CH2  C Y N 329 
TRP OXT  O N N 330 
TRP H    H N N 331 
TRP H2   H N N 332 
TRP HA   H N N 333 
TRP HB2  H N N 334 
TRP HB3  H N N 335 
TRP HD1  H N N 336 
TRP HE1  H N N 337 
TRP HE3  H N N 338 
TRP HZ2  H N N 339 
TRP HZ3  H N N 340 
TRP HH2  H N N 341 
TRP HXT  H N N 342 
TYR N    N N N 343 
TYR CA   C N S 344 
TYR C    C N N 345 
TYR O    O N N 346 
TYR CB   C N N 347 
TYR CG   C Y N 348 
TYR CD1  C Y N 349 
TYR CD2  C Y N 350 
TYR CE1  C Y N 351 
TYR CE2  C Y N 352 
TYR CZ   C Y N 353 
TYR OH   O N N 354 
TYR OXT  O N N 355 
TYR H    H N N 356 
TYR H2   H N N 357 
TYR HA   H N N 358 
TYR HB2  H N N 359 
TYR HB3  H N N 360 
TYR HD1  H N N 361 
TYR HD2  H N N 362 
TYR HE1  H N N 363 
TYR HE2  H N N 364 
TYR HH   H N N 365 
TYR HXT  H N N 366 
VAL N    N N N 367 
VAL CA   C N S 368 
VAL C    C N N 369 
VAL O    O N N 370 
VAL CB   C N N 371 
VAL CG1  C N N 372 
VAL CG2  C N N 373 
VAL OXT  O N N 374 
VAL H    H N N 375 
VAL H2   H N N 376 
VAL HA   H N N 377 
VAL HB   H N N 378 
VAL HG11 H N N 379 
VAL HG12 H N N 380 
VAL HG13 H N N 381 
VAL HG21 H N N 382 
VAL HG22 H N N 383 
VAL HG23 H N N 384 
VAL HXT  H N N 385 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HOH O   H1   sing N N 129 
HOH O   H2   sing N N 130 
ILE N   CA   sing N N 131 
ILE N   H    sing N N 132 
ILE N   H2   sing N N 133 
ILE CA  C    sing N N 134 
ILE CA  CB   sing N N 135 
ILE CA  HA   sing N N 136 
ILE C   O    doub N N 137 
ILE C   OXT  sing N N 138 
ILE CB  CG1  sing N N 139 
ILE CB  CG2  sing N N 140 
ILE CB  HB   sing N N 141 
ILE CG1 CD1  sing N N 142 
ILE CG1 HG12 sing N N 143 
ILE CG1 HG13 sing N N 144 
ILE CG2 HG21 sing N N 145 
ILE CG2 HG22 sing N N 146 
ILE CG2 HG23 sing N N 147 
ILE CD1 HD11 sing N N 148 
ILE CD1 HD12 sing N N 149 
ILE CD1 HD13 sing N N 150 
ILE OXT HXT  sing N N 151 
LEU N   CA   sing N N 152 
LEU N   H    sing N N 153 
LEU N   H2   sing N N 154 
LEU CA  C    sing N N 155 
LEU CA  CB   sing N N 156 
LEU CA  HA   sing N N 157 
LEU C   O    doub N N 158 
LEU C   OXT  sing N N 159 
LEU CB  CG   sing N N 160 
LEU CB  HB2  sing N N 161 
LEU CB  HB3  sing N N 162 
LEU CG  CD1  sing N N 163 
LEU CG  CD2  sing N N 164 
LEU CG  HG   sing N N 165 
LEU CD1 HD11 sing N N 166 
LEU CD1 HD12 sing N N 167 
LEU CD1 HD13 sing N N 168 
LEU CD2 HD21 sing N N 169 
LEU CD2 HD22 sing N N 170 
LEU CD2 HD23 sing N N 171 
LEU OXT HXT  sing N N 172 
LYS N   CA   sing N N 173 
LYS N   H    sing N N 174 
LYS N   H2   sing N N 175 
LYS CA  C    sing N N 176 
LYS CA  CB   sing N N 177 
LYS CA  HA   sing N N 178 
LYS C   O    doub N N 179 
LYS C   OXT  sing N N 180 
LYS CB  CG   sing N N 181 
LYS CB  HB2  sing N N 182 
LYS CB  HB3  sing N N 183 
LYS CG  CD   sing N N 184 
LYS CG  HG2  sing N N 185 
LYS CG  HG3  sing N N 186 
LYS CD  CE   sing N N 187 
LYS CD  HD2  sing N N 188 
LYS CD  HD3  sing N N 189 
LYS CE  NZ   sing N N 190 
LYS CE  HE2  sing N N 191 
LYS CE  HE3  sing N N 192 
LYS NZ  HZ1  sing N N 193 
LYS NZ  HZ2  sing N N 194 
LYS NZ  HZ3  sing N N 195 
LYS OXT HXT  sing N N 196 
MET N   CA   sing N N 197 
MET N   H    sing N N 198 
MET N   H2   sing N N 199 
MET CA  C    sing N N 200 
MET CA  CB   sing N N 201 
MET CA  HA   sing N N 202 
MET C   O    doub N N 203 
MET C   OXT  sing N N 204 
MET CB  CG   sing N N 205 
MET CB  HB2  sing N N 206 
MET CB  HB3  sing N N 207 
MET CG  SD   sing N N 208 
MET CG  HG2  sing N N 209 
MET CG  HG3  sing N N 210 
MET SD  CE   sing N N 211 
MET CE  HE1  sing N N 212 
MET CE  HE2  sing N N 213 
MET CE  HE3  sing N N 214 
MET OXT HXT  sing N N 215 
PHE N   CA   sing N N 216 
PHE N   H    sing N N 217 
PHE N   H2   sing N N 218 
PHE CA  C    sing N N 219 
PHE CA  CB   sing N N 220 
PHE CA  HA   sing N N 221 
PHE C   O    doub N N 222 
PHE C   OXT  sing N N 223 
PHE CB  CG   sing N N 224 
PHE CB  HB2  sing N N 225 
PHE CB  HB3  sing N N 226 
PHE CG  CD1  doub Y N 227 
PHE CG  CD2  sing Y N 228 
PHE CD1 CE1  sing Y N 229 
PHE CD1 HD1  sing N N 230 
PHE CD2 CE2  doub Y N 231 
PHE CD2 HD2  sing N N 232 
PHE CE1 CZ   doub Y N 233 
PHE CE1 HE1  sing N N 234 
PHE CE2 CZ   sing Y N 235 
PHE CE2 HE2  sing N N 236 
PHE CZ  HZ   sing N N 237 
PHE OXT HXT  sing N N 238 
PRO N   CA   sing N N 239 
PRO N   CD   sing N N 240 
PRO N   H    sing N N 241 
PRO CA  C    sing N N 242 
PRO CA  CB   sing N N 243 
PRO CA  HA   sing N N 244 
PRO C   O    doub N N 245 
PRO C   OXT  sing N N 246 
PRO CB  CG   sing N N 247 
PRO CB  HB2  sing N N 248 
PRO CB  HB3  sing N N 249 
PRO CG  CD   sing N N 250 
PRO CG  HG2  sing N N 251 
PRO CG  HG3  sing N N 252 
PRO CD  HD2  sing N N 253 
PRO CD  HD3  sing N N 254 
PRO OXT HXT  sing N N 255 
SER N   CA   sing N N 256 
SER N   H    sing N N 257 
SER N   H2   sing N N 258 
SER CA  C    sing N N 259 
SER CA  CB   sing N N 260 
SER CA  HA   sing N N 261 
SER C   O    doub N N 262 
SER C   OXT  sing N N 263 
SER CB  OG   sing N N 264 
SER CB  HB2  sing N N 265 
SER CB  HB3  sing N N 266 
SER OG  HG   sing N N 267 
SER OXT HXT  sing N N 268 
THR N   CA   sing N N 269 
THR N   H    sing N N 270 
THR N   H2   sing N N 271 
THR CA  C    sing N N 272 
THR CA  CB   sing N N 273 
THR CA  HA   sing N N 274 
THR C   O    doub N N 275 
THR C   OXT  sing N N 276 
THR CB  OG1  sing N N 277 
THR CB  CG2  sing N N 278 
THR CB  HB   sing N N 279 
THR OG1 HG1  sing N N 280 
THR CG2 HG21 sing N N 281 
THR CG2 HG22 sing N N 282 
THR CG2 HG23 sing N N 283 
THR OXT HXT  sing N N 284 
TLA O1  C1   doub N N 285 
TLA O11 C1   sing N N 286 
TLA O11 H11  sing N N 287 
TLA C1  C2   sing N N 288 
TLA C2  O2   sing N N 289 
TLA C2  C3   sing N N 290 
TLA C2  H2   sing N N 291 
TLA O2  HA   sing N N 292 
TLA C3  O3   sing N N 293 
TLA C3  C4   sing N N 294 
TLA C3  H3   sing N N 295 
TLA O3  HB   sing N N 296 
TLA C4  O4   doub N N 297 
TLA C4  O41  sing N N 298 
TLA O41 H41  sing N N 299 
TRP N   CA   sing N N 300 
TRP N   H    sing N N 301 
TRP N   H2   sing N N 302 
TRP CA  C    sing N N 303 
TRP CA  CB   sing N N 304 
TRP CA  HA   sing N N 305 
TRP C   O    doub N N 306 
TRP C   OXT  sing N N 307 
TRP CB  CG   sing N N 308 
TRP CB  HB2  sing N N 309 
TRP CB  HB3  sing N N 310 
TRP CG  CD1  doub Y N 311 
TRP CG  CD2  sing Y N 312 
TRP CD1 NE1  sing Y N 313 
TRP CD1 HD1  sing N N 314 
TRP CD2 CE2  doub Y N 315 
TRP CD2 CE3  sing Y N 316 
TRP NE1 CE2  sing Y N 317 
TRP NE1 HE1  sing N N 318 
TRP CE2 CZ2  sing Y N 319 
TRP CE3 CZ3  doub Y N 320 
TRP CE3 HE3  sing N N 321 
TRP CZ2 CH2  doub Y N 322 
TRP CZ2 HZ2  sing N N 323 
TRP CZ3 CH2  sing Y N 324 
TRP CZ3 HZ3  sing N N 325 
TRP CH2 HH2  sing N N 326 
TRP OXT HXT  sing N N 327 
TYR N   CA   sing N N 328 
TYR N   H    sing N N 329 
TYR N   H2   sing N N 330 
TYR CA  C    sing N N 331 
TYR CA  CB   sing N N 332 
TYR CA  HA   sing N N 333 
TYR C   O    doub N N 334 
TYR C   OXT  sing N N 335 
TYR CB  CG   sing N N 336 
TYR CB  HB2  sing N N 337 
TYR CB  HB3  sing N N 338 
TYR CG  CD1  doub Y N 339 
TYR CG  CD2  sing Y N 340 
TYR CD1 CE1  sing Y N 341 
TYR CD1 HD1  sing N N 342 
TYR CD2 CE2  doub Y N 343 
TYR CD2 HD2  sing N N 344 
TYR CE1 CZ   doub Y N 345 
TYR CE1 HE1  sing N N 346 
TYR CE2 CZ   sing Y N 347 
TYR CE2 HE2  sing N N 348 
TYR CZ  OH   sing N N 349 
TYR OH  HH   sing N N 350 
TYR OXT HXT  sing N N 351 
VAL N   CA   sing N N 352 
VAL N   H    sing N N 353 
VAL N   H2   sing N N 354 
VAL CA  C    sing N N 355 
VAL CA  CB   sing N N 356 
VAL CA  HA   sing N N 357 
VAL C   O    doub N N 358 
VAL C   OXT  sing N N 359 
VAL CB  CG1  sing N N 360 
VAL CB  CG2  sing N N 361 
VAL CB  HB   sing N N 362 
VAL CG1 HG11 sing N N 363 
VAL CG1 HG12 sing N N 364 
VAL CG1 HG13 sing N N 365 
VAL CG2 HG21 sing N N 366 
VAL CG2 HG22 sing N N 367 
VAL CG2 HG23 sing N N 368 
VAL OXT HXT  sing N N 369 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WR8 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   'SACLA extruder' 
_pdbx_serial_crystallography_sample_delivery.method        injection 
# 
_space_group.name_H-M_alt     'P 41 21 2' 
_space_group.name_Hall        'P 4abw 2nw' 
_space_group.IT_number        92 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FTS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017100 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017100 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006607 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? -21.87006 10.91618 -9.87568  1.000 32.04854  ? 1   ALA A N   1 
ATOM   2    C CA  . ALA A 1 1   ? -21.49834 12.33165 -10.02776 1.000 27.97329  ? 1   ALA A CA  1 
ATOM   3    C C   . ALA A 1 1   ? -20.48057 12.39843 -11.16074 1.000 23.53131  ? 1   ALA A C   1 
ATOM   4    O O   . ALA A 1 1   ? -19.74384 11.44297 -11.35874 1.000 28.32157  ? 1   ALA A O   1 
ATOM   5    C CB  . ALA A 1 1   ? -20.90675 12.86676 -8.79016  1.000 24.81330  ? 1   ALA A CB  1 
ATOM   6    N N   . THR A 1 2   ? -20.46915 13.49875 -11.91317 1.000 23.53950  ? 2   THR A N   1 
ATOM   7    C CA  A THR A 1 2   ? -19.54691 13.71056 -13.01453 0.613 22.63186  ? 2   THR A CA  1 
ATOM   8    C CA  B THR A 1 2   ? -19.49451 13.65153 -12.97932 0.387 22.60092  ? 2   THR A CA  1 
ATOM   9    C C   . THR A 1 2   ? -18.43692 14.67048 -12.57733 1.000 18.41958  ? 2   THR A C   1 
ATOM   10   O O   . THR A 1 2   ? -18.73020 15.70626 -11.99826 1.000 22.01472  ? 2   THR A O   1 
ATOM   11   C CB  A THR A 1 2   ? -20.30696 14.30789 -14.20015 0.613 26.36480  ? 2   THR A CB  1 
ATOM   12   C CB  B THR A 1 2   ? -20.12855 14.09130 -14.29545 0.387 26.33830  ? 2   THR A CB  1 
ATOM   13   O OG1 A THR A 1 2   ? -21.44777 13.49622 -14.49565 0.613 26.17304  ? 2   THR A OG1 1 
ATOM   14   O OG1 B THR A 1 2   ? -20.69609 15.38690 -14.11184 0.387 19.09986  ? 2   THR A OG1 1 
ATOM   15   C CG2 A THR A 1 2   ? -19.43569 14.39610 -15.39004 0.613 27.22918  ? 2   THR A CG2 1 
ATOM   16   C CG2 B THR A 1 2   ? -21.19042 13.11199 -14.72690 0.387 28.80478  ? 2   THR A CG2 1 
ATOM   17   N N   . PHE A 1 3   ? -17.19161 14.33760 -12.88310 1.000 21.50251  ? 3   PHE A N   1 
ATOM   18   C CA  . PHE A 1 3   ? -16.06776 15.23711 -12.68084 1.000 17.93770  ? 3   PHE A CA  1 
ATOM   19   C C   . PHE A 1 3   ? -15.46390 15.48232 -14.06042 1.000 17.10662  ? 3   PHE A C   1 
ATOM   20   O O   . PHE A 1 3   ? -15.11031 14.52424 -14.74453 1.000 24.59475  ? 3   PHE A O   1 
ATOM   21   C CB  . PHE A 1 3   ? -15.01367 14.59152 -11.79331 1.000 16.72923  ? 3   PHE A CB  1 
ATOM   22   C CG  . PHE A 1 3   ? -15.35269 14.61455 -10.35079 1.000 24.68776  ? 3   PHE A CG  1 
ATOM   23   C CD1 . PHE A 1 3   ? -16.36062 13.80362 -9.86157  1.000 21.13508  ? 3   PHE A CD1 1 
ATOM   24   C CD2 . PHE A 1 3   ? -14.65219 15.44508 -9.48799  1.000 21.46994  ? 3   PHE A CD2 1 
ATOM   25   C CE1 . PHE A 1 3   ? -16.67094 13.80617 -8.49463  1.000 22.91080  ? 3   PHE A CE1 1 
ATOM   26   C CE2 . PHE A 1 3   ? -14.95666 15.46705 -8.13329  1.000 23.70754  ? 3   PHE A CE2 1 
ATOM   27   C CZ  . PHE A 1 3   ? -15.95806 14.63860 -7.64733  1.000 19.53544  ? 3   PHE A CZ  1 
ATOM   28   N N   . GLU A 1 4   ? -15.32494 16.73320 -14.44681 1.000 16.51983  ? 4   GLU A N   1 
ATOM   29   C CA  . GLU A 1 4   ? -14.55120 17.03368 -15.64531 1.000 19.50690  ? 4   GLU A CA  1 
ATOM   30   C C   . GLU A 1 4   ? -13.16323 17.45479 -15.19477 1.000 20.42656  ? 4   GLU A C   1 
ATOM   31   O O   . GLU A 1 4   ? -13.03997 18.39302 -14.39605 1.000 22.23101  ? 4   GLU A O   1 
ATOM   32   C CB  . GLU A 1 4   ? -15.18040 18.13490 -16.49250 1.000 19.54935  ? 4   GLU A CB  1 
ATOM   33   C CG  . GLU A 1 4   ? -14.39536 18.29283 -17.79851 1.000 20.73429  ? 4   GLU A CG  1 
ATOM   34   C CD  . GLU A 1 4   ? -15.04316 19.34042 -18.75077 1.000 25.45992  ? 4   GLU A CD  1 
ATOM   35   O OE1 . GLU A 1 4   ? -15.30498 20.46509 -18.32210 1.000 23.90958  ? 4   GLU A OE1 1 
ATOM   36   O OE2 . GLU A 1 4   ? -15.29260 18.97167 -19.90512 1.000 28.79803  ? 4   GLU A OE2 1 
ATOM   37   N N   . ILE A 1 5   ? -12.12341 16.76568 -15.69119 1.000 17.00274  ? 5   ILE A N   1 
ATOM   38   C CA  . ILE A 1 5   ? -10.75810 17.07741 -15.29280 1.000 14.58868  ? 5   ILE A CA  1 
ATOM   39   C C   . ILE A 1 5   ? -10.06596 17.72071 -16.50374 1.000 16.79916  ? 5   ILE A C   1 
ATOM   40   O O   . ILE A 1 5   ? -9.96911  17.11224 -17.56975 1.000 18.91548  ? 5   ILE A O   1 
ATOM   41   C CB  . ILE A 1 5   ? -10.01397 15.83275 -14.79967 1.000 18.60152  ? 5   ILE A CB  1 
ATOM   42   C CG1 . ILE A 1 5   ? -10.76462 15.24089 -13.60284 1.000 20.23666  ? 5   ILE A CG1 1 
ATOM   43   C CG2 . ILE A 1 5   ? -8.59017  16.19236 -14.41342 1.000 17.59464  ? 5   ILE A CG2 1 
ATOM   44   C CD1 . ILE A 1 5   ? -10.37664 13.83273 -13.29794 1.000 25.07597  ? 5   ILE A CD1 1 
ATOM   45   N N   . VAL A 1 6   ? -9.62698  18.95646 -16.33294 1.000 14.71232  ? 6   VAL A N   1 
ATOM   46   C CA  . VAL A 1 6   ? -9.14126  19.78394 -17.44418 1.000 14.50501  ? 6   VAL A CA  1 
ATOM   47   C C   . VAL A 1 6   ? -7.68336  20.13201 -17.18547 1.000 15.13404  ? 6   VAL A C   1 
ATOM   48   O O   . VAL A 1 6   ? -7.37437  20.68188 -16.12865 1.000 16.41852  ? 6   VAL A O   1 
ATOM   49   C CB  . VAL A 1 6   ? -9.94952  21.07214 -17.56448 1.000 19.47530  ? 6   VAL A CB  1 
ATOM   50   C CG1 . VAL A 1 6   ? -9.39922  21.90346 -18.76745 1.000 17.89589  ? 6   VAL A CG1 1 
ATOM   51   C CG2 . VAL A 1 6   ? -11.41625 20.72186 -17.72300 1.000 16.20816  ? 6   VAL A CG2 1 
ATOM   52   N N   . ASN A 1 7   ? -6.81572  19.90116 -18.18569 1.000 12.75177  ? 7   ASN A N   1 
ATOM   53   C CA  . ASN A 1 7   ? -5.41485  20.30203 -18.06638 1.000 13.45479  ? 7   ASN A CA  1 
ATOM   54   C C   . ASN A 1 7   ? -5.22808  21.61407 -18.82223 1.000 13.93776  ? 7   ASN A C   1 
ATOM   55   O O   . ASN A 1 7   ? -5.07875  21.61175 -20.04857 1.000 19.51713  ? 7   ASN A O   1 
ATOM   56   C CB  . ASN A 1 7   ? -4.46588  19.25376 -18.63514 1.000 16.25625  ? 7   ASN A CB  1 
ATOM   57   C CG  . ASN A 1 7   ? -3.03063  19.68247 -18.45171 1.000 18.42578  ? 7   ASN A CG  1 
ATOM   58   O OD1 . ASN A 1 7   ? -2.77167  20.50243 -17.59050 1.000 17.27033  ? 7   ASN A OD1 1 
ATOM   59   N ND2 . ASN A 1 7   ? -2.10156  19.11506 -19.21435 1.000 17.22781  ? 7   ASN A ND2 1 
ATOM   60   N N   . ARG A 1 8   ? -5.19743  22.71272 -18.08854 1.000 14.94340  ? 8   ARG A N   1 
ATOM   61   C CA  . ARG A 1 8   ? -4.85044  24.00265 -18.66588 1.000 17.68629  ? 8   ARG A CA  1 
ATOM   62   C C   . ARG A 1 8   ? -3.34533  24.31100 -18.58851 1.000 17.79243  ? 8   ARG A C   1 
ATOM   63   O O   . ARG A 1 8   ? -2.90226  25.36676 -19.07685 1.000 16.09582  ? 8   ARG A O   1 
ATOM   64   C CB  . ARG A 1 8   ? -5.69296  25.09625 -17.97959 1.000 15.95780  ? 8   ARG A CB  1 
ATOM   65   C CG  . ARG A 1 8   ? -5.67338  26.46225 -18.73007 1.000 15.82881  ? 8   ARG A CG  1 
ATOM   66   C CD  . ARG A 1 8   ? -6.69235  27.42075 -18.07853 1.000 19.06401  ? 8   ARG A CD  1 
ATOM   67   N NE  . ARG A 1 8   ? -8.06886  27.01349 -18.33090 1.000 19.63209  ? 8   ARG A NE  1 
ATOM   68   C CZ  . ARG A 1 8   ? -9.08997  27.33815 -17.55934 1.000 26.82073  ? 8   ARG A CZ  1 
ATOM   69   N NH1 . ARG A 1 8   ? -8.92969  28.07437 -16.45004 1.000 23.05036  ? 8   ARG A NH1 1 
ATOM   70   N NH2 . ARG A 1 8   ? -10.30165 26.89600 -17.87554 1.000 20.40447  ? 8   ARG A NH2 1 
ATOM   71   N N   . CYS A 1 9   ? -2.54479  23.42298 -18.00281 1.000 14.76580  ? 9   CYS A N   1 
ATOM   72   C CA  . CYS A 1 9   ? -1.09820  23.62137 -18.00067 1.000 15.18304  ? 9   CYS A CA  1 
ATOM   73   C C   . CYS A 1 9   ? -0.56190  23.57714 -19.43355 1.000 18.82969  ? 9   CYS A C   1 
ATOM   74   O O   . CYS A 1 9   ? -1.11945  22.92007 -20.31656 1.000 18.58909  ? 9   CYS A O   1 
ATOM   75   C CB  . CYS A 1 9   ? -0.38227  22.55177 -17.17294 1.000 15.39564  ? 9   CYS A CB  1 
ATOM   76   S SG  . CYS A 1 9   ? -1.09524  22.41821 -15.50602 1.000 17.49106  ? 9   CYS A SG  1 
ATOM   77   N N   . SER A 1 10  ? 0.59307   24.21344 -19.63029 1.000 16.83572  ? 10  SER A N   1 
ATOM   78   C CA  . SER A 1 10  ? 1.26889   24.12136 -20.93510 1.000 21.03773  ? 10  SER A CA  1 
ATOM   79   C C   . SER A 1 10  ? 2.00830   22.81073 -21.13610 1.000 27.69570  ? 10  SER A C   1 
ATOM   80   O O   . SER A 1 10  ? 2.52334   22.55317 -22.23701 1.000 26.80812  ? 10  SER A O   1 
ATOM   81   C CB  . SER A 1 10  ? 2.25043   25.30941 -21.09311 1.000 26.65284  ? 10  SER A CB  1 
ATOM   82   O OG  . SER A 1 10  ? 3.20959   25.26894 -20.04456 1.000 28.18626  ? 10  SER A OG  1 
ATOM   83   N N   . TYR A 1 11  ? 2.08403   21.97553 -20.11135 1.000 21.45890  ? 11  TYR A N   1 
ATOM   84   C CA  . TYR A 1 11  ? 2.75702   20.70087 -20.15324 1.000 17.86971  ? 11  TYR A CA  1 
ATOM   85   C C   . TYR A 1 11  ? 1.75289   19.56498 -19.93859 1.000 16.72102  ? 11  TYR A C   1 
ATOM   86   O O   . TYR A 1 11  ? 0.69570   19.76390 -19.35146 1.000 19.04502  ? 11  TYR A O   1 
ATOM   87   C CB  . TYR A 1 11  ? 3.85303   20.62881 -19.04675 1.000 21.76493  ? 11  TYR A CB  1 
ATOM   88   C CG  . TYR A 1 11  ? 3.43525   21.09541 -17.67613 1.000 20.71151  ? 11  TYR A CG  1 
ATOM   89   C CD1 . TYR A 1 11  ? 2.86424   20.21989 -16.73835 1.000 19.63687  ? 11  TYR A CD1 1 
ATOM   90   C CD2 . TYR A 1 11  ? 3.57644   22.42200 -17.30814 1.000 23.61212  ? 11  TYR A CD2 1 
ATOM   91   C CE1 . TYR A 1 11  ? 2.49561   20.66116 -15.47423 1.000 19.67749  ? 11  TYR A CE1 1 
ATOM   92   C CE2 . TYR A 1 11  ? 3.19883   22.86725 -16.03797 1.000 25.32557  ? 11  TYR A CE2 1 
ATOM   93   C CZ  . TYR A 1 11  ? 2.67962   21.96421 -15.11858 1.000 23.68517  ? 11  TYR A CZ  1 
ATOM   94   O OH  . TYR A 1 11  ? 2.29033   22.40781 -13.87615 1.000 24.12556  ? 11  TYR A OH  1 
ATOM   95   N N   . THR A 1 12  ? 2.10631   18.38106 -20.40917 1.000 17.13083  ? 12  THR A N   1 
ATOM   96   C CA  . THR A 1 12  ? 1.27546   17.18919 -20.21382 1.000 17.22449  ? 12  THR A CA  1 
ATOM   97   C C   . THR A 1 12  ? 1.25513   16.78871 -18.74789 1.000 21.56734  ? 12  THR A C   1 
ATOM   98   O O   . THR A 1 12  ? 2.27979   16.83105 -18.07354 1.000 19.04509  ? 12  THR A O   1 
ATOM   99   C CB  . THR A 1 12  ? 1.83648   16.03806 -21.05343 1.000 19.95776  ? 12  THR A CB  1 
ATOM   100  O OG1 . THR A 1 12  ? 1.81976   16.42874 -22.43658 1.000 22.24290  ? 12  THR A OG1 1 
ATOM   101  C CG2 . THR A 1 12  ? 1.00806   14.78287 -20.91743 1.000 18.02992  ? 12  THR A CG2 1 
ATOM   102  N N   . VAL A 1 13  ? 0.08169   16.39658 -18.25154 1.000 15.59842  ? 13  VAL A N   1 
ATOM   103  C CA  . VAL A 1 13  ? -0.00503  15.79564 -16.91637 1.000 17.38255  ? 13  VAL A CA  1 
ATOM   104  C C   . VAL A 1 13  ? -0.71602  14.47293 -17.08109 1.000 20.20384  ? 13  VAL A C   1 
ATOM   105  O O   . VAL A 1 13  ? -1.38911  14.21099 -18.09202 1.000 20.61280  ? 13  VAL A O   1 
ATOM   106  C CB  . VAL A 1 13  ? -0.72352  16.66566 -15.87262 1.000 18.07935  ? 13  VAL A CB  1 
ATOM   107  C CG1 . VAL A 1 13  ? -0.02426  18.05446 -15.69493 1.000 18.92755  ? 13  VAL A CG1 1 
ATOM   108  C CG2 . VAL A 1 13  ? -2.21001  16.82326 -16.23982 1.000 19.78775  ? 13  VAL A CG2 1 
ATOM   109  N N   . TRP A 1 14  ? -0.53120  13.61064 -16.10178 1.000 15.65388  ? 14  TRP A N   1 
ATOM   110  C CA  . TRP A 1 14  ? -1.25671  12.35673 -16.08210 1.000 13.86966  ? 14  TRP A CA  1 
ATOM   111  C C   . TRP A 1 14  ? -2.19325  12.40487 -14.88003 1.000 19.62802  ? 14  TRP A C   1 
ATOM   112  O O   . TRP A 1 14  ? -1.75497  12.27183 -13.73058 1.000 17.55243  ? 14  TRP A O   1 
ATOM   113  C CB  . TRP A 1 14  ? -0.30655  11.16929 -16.01363 1.000 18.60469  ? 14  TRP A CB  1 
ATOM   114  C CG  . TRP A 1 14  ? 0.41440   10.89300 -17.31550 1.000 17.12378  ? 14  TRP A CG  1 
ATOM   115  C CD1 . TRP A 1 14  ? 0.12550   9.90558  -18.24004 1.000 20.92186  ? 14  TRP A CD1 1 
ATOM   116  C CD2 . TRP A 1 14  ? 1.51114   11.64552 -17.86124 1.000 17.64874  ? 14  TRP A CD2 1 
ATOM   117  N NE1 . TRP A 1 14  ? 1.02320   9.97514  -19.30003 1.000 20.09134  ? 14  TRP A NE1 1 
ATOM   118  C CE2 . TRP A 1 14  ? 1.87467   11.03110 -19.10104 1.000 18.65214  ? 14  TRP A CE2 1 
ATOM   119  C CE3 . TRP A 1 14  ? 2.26833   12.72570 -17.39444 1.000 18.54975  ? 14  TRP A CE3 1 
ATOM   120  C CZ2 . TRP A 1 14  ? 2.93855   11.47892 -19.86743 1.000 20.97155  ? 14  TRP A CZ2 1 
ATOM   121  C CZ3 . TRP A 1 14  ? 3.33290   13.19933 -18.19971 1.000 22.53448  ? 14  TRP A CZ3 1 
ATOM   122  C CH2 . TRP A 1 14  ? 3.65619   12.56590 -19.40320 1.000 20.13282  ? 14  TRP A CH2 1 
ATOM   123  N N   . ALA A 1 15  ? -3.46869  12.63605 -15.13971 1.000 18.28890  ? 15  ALA A N   1 
ATOM   124  C CA  . ALA A 1 15  ? -4.44781  12.74933 -14.05238 1.000 17.96773  ? 15  ALA A CA  1 
ATOM   125  C C   . ALA A 1 15  ? -4.61306  11.38404 -13.40301 1.000 16.74843  ? 15  ALA A C   1 
ATOM   126  O O   . ALA A 1 15  ? -4.35191  10.34899 -14.02999 1.000 17.17485  ? 15  ALA A O   1 
ATOM   127  C CB  . ALA A 1 15  ? -5.78507  13.21900 -14.60537 1.000 15.74238  ? 15  ALA A CB  1 
ATOM   128  N N   . ALA A 1 16  ? -4.99466  11.39753 -12.12680 1.000 18.40470  ? 16  ALA A N   1 
ATOM   129  C CA  . ALA A 1 16  ? -5.23105  10.19645 -11.33871 1.000 19.43645  ? 16  ALA A CA  1 
ATOM   130  C C   . ALA A 1 16  ? -6.46466  10.43108 -10.48895 1.000 20.75030  ? 16  ALA A C   1 
ATOM   131  O O   . ALA A 1 16  ? -6.72606  11.55913 -10.05646 1.000 18.05217  ? 16  ALA A O   1 
ATOM   132  C CB  . ALA A 1 16  ? -3.99400  9.84975  -10.46369 1.000 16.42336  ? 16  ALA A CB  1 
ATOM   133  N N   . ALA A 1 17  ? -7.25678  9.36685  -10.27811 1.000 18.28548  ? 17  ALA A N   1 
ATOM   134  C CA  . ALA A 1 17  ? -8.44936  9.45037  -9.44248  1.000 19.09038  ? 17  ALA A CA  1 
ATOM   135  C C   . ALA A 1 17  ? -8.59455  8.13297  -8.68596  1.000 19.50288  ? 17  ALA A C   1 
ATOM   136  O O   . ALA A 1 17  ? -8.64743  7.06506  -9.30103  1.000 22.13281  ? 17  ALA A O   1 
ATOM   137  C CB  . ALA A 1 17  ? -9.69834  9.71164  -10.28630 1.000 18.83513  ? 17  ALA A CB  1 
ATOM   138  N N   . SER A 1 18  ? -8.65251  8.20496  -7.36553  1.000 15.50269  ? 18  SER A N   1 
ATOM   139  C CA  . SER A 1 18  ? -8.61024  6.99510  -6.56172  1.000 17.56182  ? 18  SER A CA  1 
ATOM   140  C C   . SER A 1 18  ? -9.37687  7.25912  -5.27964  1.000 19.74351  ? 18  SER A C   1 
ATOM   141  O O   . SER A 1 18  ? -9.45260  8.39420  -4.81097  1.000 17.98992  ? 18  SER A O   1 
ATOM   142  C CB  . SER A 1 18  ? -7.15020  6.59452  -6.23535  1.000 20.71523  ? 18  SER A CB  1 
ATOM   143  O OG  . SER A 1 18  ? -7.05488  5.51056  -5.32029  1.000 27.15658  ? 18  SER A OG  1 
ATOM   144  N N   . LYS A 1 19  ? -9.90419  6.19567  -4.67515  1.000 19.77430  ? 19  LYS A N   1 
ATOM   145  C CA  . LYS A 1 19  ? -10.33981 6.34817  -3.28885  1.000 21.65223  ? 19  LYS A CA  1 
ATOM   146  C C   . LYS A 1 19  ? -9.45036  5.55987  -2.33389  1.000 28.06197  ? 19  LYS A C   1 
ATOM   147  O O   . LYS A 1 19  ? -9.87440  5.23868  -1.21988  1.000 29.76690  ? 19  LYS A O   1 
ATOM   148  C CB  . LYS A 1 19  ? -11.82141 5.97214  -3.11578  1.000 26.64619  ? 19  LYS A CB  1 
ATOM   149  C CG  . LYS A 1 19  ? -12.18262 4.50114  -3.41330  1.000 30.69511  ? 19  LYS A CG  1 
ATOM   150  C CD  . LYS A 1 19  ? -13.70533 4.23416  -3.10605  1.000 33.89495  ? 19  LYS A CD  1 
ATOM   151  C CE  . LYS A 1 19  ? -14.04688 2.74755  -2.98469  1.000 46.90090  ? 19  LYS A CE  1 
ATOM   152  N NZ  . LYS A 1 19  ? -13.41102 2.14441  -1.76644  1.000 47.38927  ? 19  LYS A NZ  1 
ATOM   153  N N   . GLY A 1 20  ? -8.22278  5.24626  -2.74695  1.000 25.81175  ? 20  GLY A N   1 
ATOM   154  C CA  . GLY A 1 20  ? -7.24955  4.70562  -1.82274  1.000 25.54787  ? 20  GLY A CA  1 
ATOM   155  C C   . GLY A 1 20  ? -7.09184  3.20428  -1.91479  1.000 26.72843  ? 20  GLY A C   1 
ATOM   156  O O   . GLY A 1 20  ? -5.98018  2.68090  -1.88095  1.000 28.98079  ? 20  GLY A O   1 
ATOM   157  N N   . ASP A 1 21  ? -8.20985  2.49751  -2.06392  1.000 30.51130  ? 21  ASP A N   1 
ATOM   158  C CA  . ASP A 1 21  ? -8.16728  1.05459  -2.25283  1.000 24.76213  ? 21  ASP A CA  1 
ATOM   159  C C   . ASP A 1 21  ? -8.76804  0.63394  -3.58675  1.000 39.72605  ? 21  ASP A C   1 
ATOM   160  O O   . ASP A 1 21  ? -8.99050  -0.54779 -3.80675  1.000 35.98419  ? 21  ASP A O   1 
ATOM   161  C CB  . ASP A 1 21  ? -8.87182  0.36085  -1.07745  1.000 33.12122  ? 21  ASP A CB  1 
ATOM   162  C CG  . ASP A 1 21  ? -10.31080 0.78126  -0.92282  1.000 39.31051  ? 21  ASP A CG  1 
ATOM   163  O OD1 . ASP A 1 21  ? -10.84518 1.61101  -1.71250  1.000 37.78348  ? 21  ASP A OD1 1 
ATOM   164  O OD2 . ASP A 1 21  ? -10.94150 0.27797  0.01447   1.000 55.10630  ? 21  ASP A OD2 1 
ATOM   165  N N   . ALA A 1 22  ? -9.02595  1.56911  -4.48640  1.000 28.17837  ? 22  ALA A N   1 
ATOM   166  C CA  . ALA A 1 22  ? -9.64366  1.25441  -5.75979  1.000 28.04720  ? 22  ALA A CA  1 
ATOM   167  C C   . ALA A 1 22  ? -9.49806  2.47891  -6.65437  1.000 19.71471  ? 22  ALA A C   1 
ATOM   168  O O   . ALA A 1 22  ? -9.54944  3.60808  -6.15460  1.000 25.12368  ? 22  ALA A O   1 
ATOM   169  C CB  . ALA A 1 22  ? -11.13016 0.93315  -5.59425  1.000 25.54516  ? 22  ALA A CB  1 
ATOM   170  N N   . ALA A 1 23  ? -9.41867  2.24026  -7.96323  1.000 21.65751  ? 23  ALA A N   1 
ATOM   171  C CA  . ALA A 1 23  ? -9.54935  3.33228  -8.93190  1.000 22.68958  ? 23  ALA A CA  1 
ATOM   172  C C   . ALA A 1 23  ? -10.93778 3.97604  -8.84225  1.000 31.47649  ? 23  ALA A C   1 
ATOM   173  O O   . ALA A 1 23  ? -11.92243 3.33123  -8.46214  1.000 30.36511  ? 23  ALA A O   1 
ATOM   174  C CB  . ALA A 1 23  ? -9.31877  2.82075  -10.34415 1.000 24.69074  ? 23  ALA A CB  1 
ATOM   175  N N   . LEU A 1 24  ? -11.01257 5.27071  -9.17329  1.000 20.77275  ? 24  LEU A N   1 
ATOM   176  C CA  . LEU A 1 24  ? -12.27338 5.89998  -9.54992  1.000 21.84193  ? 24  LEU A CA  1 
ATOM   177  C C   . LEU A 1 24  ? -12.33812 5.95787  -11.07498 1.000 25.62879  ? 24  LEU A C   1 
ATOM   178  O O   . LEU A 1 24  ? -11.39805 6.42053  -11.71893 1.000 24.67043  ? 24  LEU A O   1 
ATOM   179  C CB  . LEU A 1 24  ? -12.40078 7.31023  -8.96858  1.000 22.13342  ? 24  LEU A CB  1 
ATOM   180  C CG  . LEU A 1 24  ? -12.37752 7.34049  -7.42245  1.000 23.04934  ? 24  LEU A CG  1 
ATOM   181  C CD1 . LEU A 1 24  ? -12.55920 8.80873  -6.95328  1.000 21.43896  ? 24  LEU A CD1 1 
ATOM   182  C CD2 . LEU A 1 24  ? -13.46491 6.46921  -6.87865  1.000 26.39158  ? 24  LEU A CD2 1 
ATOM   183  N N   . ASP A 1 25  ? -13.43581 5.46324  -11.65112 1.000 24.29101  ? 25  ASP A N   1 
ATOM   184  C CA  . ASP A 1 25  ? -13.52172 5.38074  -13.09755 1.000 20.52545  ? 25  ASP A CA  1 
ATOM   185  C C   . ASP A 1 25  ? -12.29795 4.61844  -13.59820 1.000 21.33043  ? 25  ASP A C   1 
ATOM   186  O O   . ASP A 1 25  ? -11.90156 3.63597  -12.97446 1.000 25.73986  ? 25  ASP A O   1 
ATOM   187  C CB  . ASP A 1 25  ? -13.68496 6.78883  -13.68721 1.000 20.68370  ? 25  ASP A CB  1 
ATOM   188  C CG  . ASP A 1 25  ? -14.21858 6.78899  -15.12944 1.000 26.39921  ? 25  ASP A CG  1 
ATOM   189  O OD1 . ASP A 1 25  ? -13.45192 6.40518  -16.04570 1.000 30.79268  ? 25  ASP A OD1 1 
ATOM   190  O OD2 . ASP A 1 25  ? -15.37188 7.23279  -15.32614 1.000 26.23503  ? 25  ASP A OD2 1 
ATOM   191  N N   . ALA A 1 26  ? -11.65020 5.05681  -14.66406 1.000 21.23624  ? 26  ALA A N   1 
ATOM   192  C CA  . ALA A 1 26  ? -10.47284 4.33818  -15.14635 1.000 21.19596  ? 26  ALA A CA  1 
ATOM   193  C C   . ALA A 1 26  ? -9.23355  4.53312  -14.27166 1.000 24.57006  ? 26  ALA A C   1 
ATOM   194  O O   . ALA A 1 26  ? -8.24978  3.82766  -14.45853 1.000 27.58417  ? 26  ALA A O   1 
ATOM   195  C CB  . ALA A 1 26  ? -10.13797 4.78157  -16.57370 1.000 26.28738  ? 26  ALA A CB  1 
ATOM   196  N N   . GLY A 1 27  ? -9.24493  5.45614  -13.31563 1.000 20.53349  ? 27  GLY A N   1 
ATOM   197  C CA  . GLY A 1 27  ? -8.09370  5.62203  -12.41246 1.000 18.60629  ? 27  GLY A CA  1 
ATOM   198  C C   . GLY A 1 27  ? -6.99163  6.54702  -12.90417 1.000 24.73826  ? 27  GLY A C   1 
ATOM   199  O O   . GLY A 1 27  ? -6.30798  7.14378  -12.09309 1.000 21.09877  ? 27  GLY A O   1 
ATOM   200  N N   . GLY A 1 28  ? -6.76625  6.66969  -14.20006 1.000 19.62244  ? 28  GLY A N   1 
ATOM   201  C CA  . GLY A 1 28  ? -5.73438  7.58913  -14.62728 1.000 18.61783  ? 28  GLY A CA  1 
ATOM   202  C C   . GLY A 1 28  ? -5.76583  7.72742  -16.13010 1.000 21.63621  ? 28  GLY A C   1 
ATOM   203  O O   . GLY A 1 28  ? -6.27097  6.85878  -16.83432 1.000 24.39068  ? 28  GLY A O   1 
ATOM   204  N N   . ARG A 1 29  ? -5.22278  8.83993  -16.61484 1.000 18.23142  ? 29  ARG A N   1 
ATOM   205  C CA  . ARG A 1 29  ? -5.19476  9.06454  -18.05918 1.000 20.33505  ? 29  ARG A CA  1 
ATOM   206  C C   . ARG A 1 29  ? -4.21717  10.18390 -18.34905 1.000 18.95426  ? 29  ARG A C   1 
ATOM   207  O O   . ARG A 1 29  ? -4.07875  11.10667 -17.54656 1.000 17.00069  ? 29  ARG A O   1 
ATOM   208  C CB  . ARG A 1 29  ? -6.57628  9.47230  -18.60414 1.000 21.38247  ? 29  ARG A CB  1 
ATOM   209  C CG  . ARG A 1 29  ? -6.81267  8.97308  -20.01741 1.000 29.30158  ? 29  ARG A CG  1 
ATOM   210  C CD  . ARG A 1 29  ? -7.90524  9.79416  -20.64929 1.000 26.14255  ? 29  ARG A CD  1 
ATOM   211  N NE  . ARG A 1 29  ? -7.37655  11.02641 -21.20511 1.000 23.45662  ? 29  ARG A NE  1 
ATOM   212  C CZ  . ARG A 1 29  ? -8.08829  11.83169 -21.98505 1.000 24.03479  ? 29  ARG A CZ  1 
ATOM   213  N NH1 . ARG A 1 29  ? -9.36964  11.59407 -22.21619 1.000 20.18287  ? 29  ARG A NH1 1 
ATOM   214  N NH2 . ARG A 1 29  ? -7.47975  12.86300 -22.58699 1.000 24.44403  ? 29  ARG A NH2 1 
ATOM   215  N N   . GLN A 1 30  ? -3.57848  10.11054 -19.50569 1.000 17.65403  ? 30  GLN A N   1 
ATOM   216  C CA  . GLN A 1 30  ? -2.77019  11.22965 -19.99205 1.000 16.18051  ? 30  GLN A CA  1 
ATOM   217  C C   . GLN A 1 30  ? -3.66007  12.38936 -20.42933 1.000 21.76704  ? 30  GLN A C   1 
ATOM   218  O O   . GLN A 1 30  ? -4.65727  12.17758 -21.09189 1.000 20.52294  ? 30  GLN A O   1 
ATOM   219  C CB  . GLN A 1 30  ? -1.90386  10.76674 -21.17795 1.000 19.06808  ? 30  GLN A CB  1 
ATOM   220  C CG  . GLN A 1 30  ? -0.97510  11.89312 -21.69299 1.000 20.30657  ? 30  GLN A CG  1 
ATOM   221  C CD  . GLN A 1 30  ? -0.01212  11.39000 -22.78889 1.000 25.72282  ? 30  GLN A CD  1 
ATOM   222  O OE1 . GLN A 1 30  ? 0.45479   10.26463 -22.71634 1.000 26.08925  ? 30  GLN A OE1 1 
ATOM   223  N NE2 . GLN A 1 30  ? 0.23516   12.20684 -23.80325 1.000 25.71084  ? 30  GLN A NE2 1 
ATOM   224  N N   . LEU A 1 31  ? -3.30437  13.62199 -20.06104 1.000 15.80023  ? 31  LEU A N   1 
ATOM   225  C CA  . LEU A 1 31  ? -4.00374  14.82168 -20.52999 1.000 18.84695  ? 31  LEU A CA  1 
ATOM   226  C C   . LEU A 1 31  ? -2.95289  15.73345 -21.12566 1.000 19.67395  ? 31  LEU A C   1 
ATOM   227  O O   . LEU A 1 31  ? -2.19114  16.37264 -20.38202 1.000 17.75733  ? 31  LEU A O   1 
ATOM   228  C CB  . LEU A 1 31  ? -4.73389  15.57755 -19.39912 1.000 18.17515  ? 31  LEU A CB  1 
ATOM   229  C CG  . LEU A 1 31  ? -5.93069  14.90978 -18.72079 1.000 23.88960  ? 31  LEU A CG  1 
ATOM   230  C CD1 . LEU A 1 31  ? -6.44191  15.85734 -17.68957 1.000 27.12512  ? 31  LEU A CD1 1 
ATOM   231  C CD2 . LEU A 1 31  ? -6.97481  14.82643 -19.76992 1.000 24.26660  ? 31  LEU A CD2 1 
ATOM   232  N N   . ASN A 1 32  ? -2.95021  15.86620 -22.44961 1.000 18.00653  ? 32  ASN A N   1 
ATOM   233  C CA  . ASN A 1 32  ? -2.14345  16.91776 -23.04476 1.000 15.21395  ? 32  ASN A CA  1 
ATOM   234  C C   . ASN A 1 32  ? -2.69753  18.28619 -22.68526 1.000 17.99630  ? 32  ASN A C   1 
ATOM   235  O O   . ASN A 1 32  ? -3.82111  18.41701 -22.20851 1.000 17.46346  ? 32  ASN A O   1 
ATOM   236  C CB  . ASN A 1 32  ? -2.10340  16.73741 -24.57632 1.000 19.36915  ? 32  ASN A CB  1 
ATOM   237  C CG  . ASN A 1 32  ? -1.41015  15.45852 -24.94087 1.000 25.77519  ? 32  ASN A CG  1 
ATOM   238  O OD1 . ASN A 1 32  ? -0.47772  15.01114 -24.25036 1.000 29.10102  ? 32  ASN A OD1 1 
ATOM   239  N ND2 . ASN A 1 32  ? -1.86363  14.83715 -25.98321 1.000 34.92741  ? 32  ASN A ND2 1 
ATOM   240  N N   . SER A 1 33  ? -1.88879  19.32681 -22.94858 1.000 15.15191  ? 33  SER A N   1 
ATOM   241  C CA  . SER A 1 33  ? -2.31144  20.70843 -22.70763 1.000 16.29889  ? 33  SER A CA  1 
ATOM   242  C C   . SER A 1 33  ? -3.62263  21.00936 -23.43089 1.000 18.52615  ? 33  SER A C   1 
ATOM   243  O O   . SER A 1 33  ? -3.69374  20.89859 -24.66011 1.000 18.20339  ? 33  SER A O   1 
ATOM   244  C CB  . SER A 1 33  ? -1.24016  21.68705 -23.19583 1.000 16.59860  ? 33  SER A CB  1 
ATOM   245  O OG  . SER A 1 33  ? -1.64887  23.00916 -22.94914 1.000 20.65524  ? 33  SER A OG  1 
ATOM   246  N N   . GLY A 1 34  ? -4.64458  21.39955 -22.65980 1.000 15.20085  ? 34  GLY A N   1 
ATOM   247  C CA  . GLY A 1 34  ? -5.97280  21.66815 -23.16236 1.000 14.61923  ? 34  GLY A CA  1 
ATOM   248  C C   . GLY A 1 34  ? -6.95235  20.51953 -23.08399 1.000 16.27811  ? 34  GLY A C   1 
ATOM   249  O O   . GLY A 1 34  ? -8.16123  20.76259 -23.23843 1.000 19.55112  ? 34  GLY A O   1 
ATOM   250  N N   . GLU A 1 35  ? -6.49204  19.28215 -22.88403 1.000 15.73058  ? 35  GLU A N   1 
ATOM   251  C CA  . GLU A 1 35  ? -7.42465  18.16679 -22.93907 1.000 15.80964  ? 35  GLU A CA  1 
ATOM   252  C C   . GLU A 1 35  ? -8.30568  18.11574 -21.68577 1.000 18.36148  ? 35  GLU A C   1 
ATOM   253  O O   . GLU A 1 35  ? -7.93093  18.57774 -20.59379 1.000 19.64975  ? 35  GLU A O   1 
ATOM   254  C CB  . GLU A 1 35  ? -6.70133  16.83377 -23.10103 1.000 16.41284  ? 35  GLU A CB  1 
ATOM   255  C CG  . GLU A 1 35  ? -6.09045  16.68406 -24.52759 1.000 15.11390  ? 35  GLU A CG  1 
ATOM   256  C CD  . GLU A 1 35  ? -5.54818  15.30756 -24.79192 1.000 21.36893  ? 35  GLU A CD  1 
ATOM   257  O OE1 . GLU A 1 35  ? -5.08096  14.63422 -23.84591 1.000 18.48546  ? 35  GLU A OE1 1 
ATOM   258  O OE2 . GLU A 1 35  ? -5.60259  14.89181 -25.95633 1.000 24.40979  ? 35  GLU A OE2 1 
ATOM   259  N N   . SER A 1 36  ? -9.48538  17.54232 -21.85431 1.000 14.55207  ? 36  SER A N   1 
ATOM   260  C CA  . SER A 1 36  ? -10.45117 17.35220 -20.77455 1.000 16.40986  ? 36  SER A CA  1 
ATOM   261  C C   . SER A 1 36  ? -10.83118 15.88074 -20.70429 1.000 23.74526  ? 36  SER A C   1 
ATOM   262  O O   . SER A 1 36  ? -10.93543 15.19527 -21.72718 1.000 20.19517  ? 36  SER A O   1 
ATOM   263  C CB  . SER A 1 36  ? -11.75138 18.16770 -20.99904 1.000 21.04941  ? 36  SER A CB  1 
ATOM   264  O OG  . SER A 1 36  ? -11.44261 19.52033 -21.25404 1.000 21.79107  ? 36  SER A OG  1 
ATOM   265  N N   . TRP A 1 37  ? -11.04877 15.40623 -19.49802 1.000 16.83065  ? 37  TRP A N   1 
ATOM   266  C CA  . TRP A 1 37  ? -11.33768 14.00102 -19.27451 1.000 18.93941  ? 37  TRP A CA  1 
ATOM   267  C C   . TRP A 1 37  ? -12.50880 13.98406 -18.30029 1.000 21.55164  ? 37  TRP A C   1 
ATOM   268  O O   . TRP A 1 37  ? -12.40155 14.53441 -17.21187 1.000 19.36703  ? 37  TRP A O   1 
ATOM   269  C CB  . TRP A 1 37  ? -10.12613 13.28891 -18.67815 1.000 19.66870  ? 37  TRP A CB  1 
ATOM   270  C CG  . TRP A 1 37  ? -10.33599 11.84659 -18.31567 1.000 21.26848  ? 37  TRP A CG  1 
ATOM   271  C CD1 . TRP A 1 37  ? -11.07542 10.91710 -18.97550 1.000 25.42727  ? 37  TRP A CD1 1 
ATOM   272  C CD2 . TRP A 1 37  ? -9.78032  11.18218 -17.16106 1.000 21.98381  ? 37  TRP A CD2 1 
ATOM   273  N NE1 . TRP A 1 37  ? -10.97246 9.69619  -18.32008 1.000 25.80746  ? 37  TRP A NE1 1 
ATOM   274  C CE2 . TRP A 1 37  ? -10.18515 9.83293  -17.21763 1.000 23.47803  ? 37  TRP A CE2 1 
ATOM   275  C CE3 . TRP A 1 37  ? -8.96834  11.60697 -16.10452 1.000 22.46825  ? 37  TRP A CE3 1 
ATOM   276  C CZ2 . TRP A 1 37  ? -9.81468  8.90039  -16.23984 1.000 25.79037  ? 37  TRP A CZ2 1 
ATOM   277  C CZ3 . TRP A 1 37  ? -8.57979  10.67944 -15.13943 1.000 25.27954  ? 37  TRP A CZ3 1 
ATOM   278  C CH2 . TRP A 1 37  ? -9.02758  9.34963  -15.20944 1.000 21.19752  ? 37  TRP A CH2 1 
ATOM   279  N N   . THR A 1 38  ? -13.62341 13.39973 -18.70973 1.000 19.65506  ? 38  THR A N   1 
ATOM   280  C CA  . THR A 1 38  ? -14.82306 13.33131 -17.88025 1.000 21.93817  ? 38  THR A CA  1 
ATOM   281  C C   . THR A 1 38  ? -14.89403 11.94943 -17.24098 1.000 24.74077  ? 38  THR A C   1 
ATOM   282  O O   . THR A 1 38  ? -14.82352 10.93495 -17.95473 1.000 23.15177  ? 38  THR A O   1 
ATOM   283  C CB  . THR A 1 38  ? -16.05535 13.58518 -18.74887 1.000 27.16505  ? 38  THR A CB  1 
ATOM   284  O OG1 . THR A 1 38  ? -15.94599 14.89502 -19.31868 1.000 30.28782  ? 38  THR A OG1 1 
ATOM   285  C CG2 . THR A 1 38  ? -17.28268 13.52253 -17.90012 1.000 34.30618  ? 38  THR A CG2 1 
ATOM   286  N N   . ILE A 1 39  ? -15.00322 11.90226 -15.90851 1.000 21.54070  ? 39  ILE A N   1 
ATOM   287  C CA  . ILE A 1 39  ? -15.13773 10.63240 -15.22881 1.000 20.13763  ? 39  ILE A CA  1 
ATOM   288  C C   . ILE A 1 39  ? -16.44036 10.62006 -14.46798 1.000 25.94241  ? 39  ILE A C   1 
ATOM   289  O O   . ILE A 1 39  ? -17.00345 11.66102 -14.12296 1.000 19.52353  ? 39  ILE A O   1 
ATOM   290  C CB  . ILE A 1 39  ? -13.97969 10.33808 -14.27281 1.000 16.65691  ? 39  ILE A CB  1 
ATOM   291  C CG1 . ILE A 1 39  ? -13.97294 11.36052 -13.13278 1.000 18.14348  ? 39  ILE A CG1 1 
ATOM   292  C CG2 . ILE A 1 39  ? -12.66586 10.28765 -15.09792 1.000 22.88692  ? 39  ILE A CG2 1 
ATOM   293  C CD1 . ILE A 1 39  ? -12.89228 10.96951 -12.03661 1.000 20.38384  ? 39  ILE A CD1 1 
ATOM   294  N N   . ASN A 1 40  ? -16.87985 9.41128  -14.15164 1.000 23.66374  ? 40  ASN A N   1 
ATOM   295  C CA  . ASN A 1 40  ? -18.05772 9.21897  -13.31913 1.000 21.90006  ? 40  ASN A CA  1 
ATOM   296  C C   . ASN A 1 40  ? -17.64323 8.60000  -11.99980 1.000 21.30516  ? 40  ASN A C   1 
ATOM   297  O O   . ASN A 1 40  ? -16.90419 7.61982  -11.98212 1.000 29.96804  ? 40  ASN A O   1 
ATOM   298  C CB  . ASN A 1 40  ? -19.08089 8.32709  -14.03059 1.000 30.55906  ? 40  ASN A CB  1 
ATOM   299  C CG  . ASN A 1 40  ? -19.88046 9.13329  -15.06011 1.000 55.71398  ? 40  ASN A CG  1 
ATOM   300  O OD1 . ASN A 1 40  ? -20.73676 9.95609  -14.69880 1.000 63.52893  ? 40  ASN A OD1 1 
ATOM   301  N ND2 . ASN A 1 40  ? -19.53353 8.97568  -16.33335 1.000 59.83414  ? 40  ASN A ND2 1 
ATOM   302  N N   . VAL A 1 41  ? -18.13477 9.17540  -10.92166 1.000 21.55670  ? 41  VAL A N   1 
ATOM   303  C CA  . VAL A 1 41  ? -17.78402 8.77407  -9.56959  1.000 22.36764  ? 41  VAL A CA  1 
ATOM   304  C C   . VAL A 1 41  ? -19.07981 8.33196  -8.90708  1.000 23.98254  ? 41  VAL A C   1 
ATOM   305  O O   . VAL A 1 41  ? -20.04330 9.09423  -8.87291  1.000 25.29595  ? 41  VAL A O   1 
ATOM   306  C CB  . VAL A 1 41  ? -17.10168 9.92232  -8.80481  1.000 24.12786  ? 41  VAL A CB  1 
ATOM   307  C CG1 . VAL A 1 41  ? -16.85261 9.49502  -7.35101  1.000 24.41286  ? 41  VAL A CG1 1 
ATOM   308  C CG2 . VAL A 1 41  ? -15.74689 10.26627 -9.51328  1.000 26.46726  ? 41  VAL A CG2 1 
ATOM   309  N N   . GLU A 1 42  ? -19.08984 7.11126  -8.37728  1.000 24.76599  ? 42  GLU A N   1 
ATOM   310  C CA  . GLU A 1 42  ? -20.31477 6.57500  -7.80167  1.000 21.59637  ? 42  GLU A CA  1 
ATOM   311  C C   . GLU A 1 42  ? -20.78721 7.42245  -6.61136  1.000 26.81420  ? 42  GLU A C   1 
ATOM   312  O O   . GLU A 1 42  ? -19.96915 7.86705  -5.79284  1.000 26.79396  ? 42  GLU A O   1 
ATOM   313  C CB  . GLU A 1 42  ? -20.07134 5.13231  -7.36749  1.000 28.11153  ? 42  GLU A CB  1 
ATOM   314  C CG  . GLU A 1 42  ? -21.33745 4.31348  -7.14436  1.000 58.38214  ? 42  GLU A CG  1 
ATOM   315  C CD  . GLU A 1 42  ? -20.98178 2.86922  -6.84490  1.000 84.84402  ? 42  GLU A CD  1 
ATOM   316  O OE1 . GLU A 1 42  ? -20.05398 2.36966  -7.52563  1.000 90.12238  ? 42  GLU A OE1 1 
ATOM   317  O OE2 . GLU A 1 42  ? -21.57663 2.25891  -5.92034  1.000 69.78662  ? 42  GLU A OE2 1 
ATOM   318  N N   . PRO A 1 43  ? -22.09068 7.67479  -6.49601  1.000 26.17240  ? 43  PRO A N   1 
ATOM   319  C CA  . PRO A 1 43  ? -22.62222 8.37076  -5.32476  1.000 22.85604  ? 43  PRO A CA  1 
ATOM   320  C C   . PRO A 1 43  ? -22.21230 7.64639  -4.05521  1.000 23.18778  ? 43  PRO A C   1 
ATOM   321  O O   . PRO A 1 43  ? -22.01130 6.42779  -4.06100  1.000 23.01180  ? 43  PRO A O   1 
ATOM   322  C CB  . PRO A 1 43  ? -24.14281 8.29667  -5.51748  1.000 27.16694  ? 43  PRO A CB  1 
ATOM   323  C CG  . PRO A 1 43  ? -24.29759 8.10368  -6.99894  1.000 34.71097  ? 43  PRO A CG  1 
ATOM   324  C CD  . PRO A 1 43  ? -23.15886 7.24093  -7.40862  1.000 27.85891  ? 43  PRO A CD  1 
ATOM   325  N N   . GLY A 1 44  ? -22.08442 8.41937  -2.97661  1.000 23.48579  ? 44  GLY A N   1 
ATOM   326  C CA  . GLY A 1 44  ? -21.66850 7.85679  -1.70949  1.000 24.45385  ? 44  GLY A CA  1 
ATOM   327  C C   . GLY A 1 44  ? -20.17768 7.64329  -1.57178  1.000 31.87730  ? 44  GLY A C   1 
ATOM   328  O O   . GLY A 1 44  ? -19.73428 7.21122  -0.50492  1.000 27.65549  ? 44  GLY A O   1 
ATOM   329  N N   . THR A 1 45  ? -19.38843 7.93323  -2.60676  1.000 25.09203  ? 45  THR A N   1 
ATOM   330  C CA  . THR A 1 45  ? -17.94043 7.73129  -2.51906  1.000 22.15436  ? 45  THR A CA  1 
ATOM   331  C C   . THR A 1 45  ? -17.36791 8.58329  -1.39329  1.000 21.38241  ? 45  THR A C   1 
ATOM   332  O O   . THR A 1 45  ? -17.61989 9.79061  -1.30800  1.000 26.95704  ? 45  THR A O   1 
ATOM   333  C CB  . THR A 1 45  ? -17.24386 8.10169  -3.82936  1.000 21.27237  ? 45  THR A CB  1 
ATOM   334  O OG1 . THR A 1 45  ? -17.59568 7.15456  -4.84418  1.000 28.71384  ? 45  THR A OG1 1 
ATOM   335  C CG2 . THR A 1 45  ? -15.71108 8.08958  -3.64273  1.000 27.14245  ? 45  THR A CG2 1 
ATOM   336  N N   . ASN A 1 46  ? -16.59118 7.95309  -0.52908  1.000 20.05144  ? 46  ASN A N   1 
ATOM   337  C CA  . ASN A 1 46  ? -16.02814 8.63786  0.62874   1.000 22.90334  ? 46  ASN A CA  1 
ATOM   338  C C   . ASN A 1 46  ? -14.50472 8.64375  0.49841   1.000 24.58577  ? 46  ASN A C   1 
ATOM   339  O O   . ASN A 1 46  ? -13.91171 7.59756  0.23922   1.000 25.25113  ? 46  ASN A O   1 
ATOM   340  C CB  . ASN A 1 46  ? -16.44483 7.89246  1.89345   1.000 27.01535  ? 46  ASN A CB  1 
ATOM   341  C CG  . ASN A 1 46  ? -16.47625 8.77203  3.07304   1.000 44.83072  ? 46  ASN A CG  1 
ATOM   342  O OD1 . ASN A 1 46  ? -15.45775 9.05454  3.68751   1.000 59.14825  ? 46  ASN A OD1 1 
ATOM   343  N ND2 . ASN A 1 46  ? -17.65706 9.23757  3.40424   1.000 70.78277  ? 46  ASN A ND2 1 
ATOM   344  N N   . GLY A 1 47  ? -13.87379 9.80049  0.66561   1.000 23.71461  ? 47  GLY A N   1 
ATOM   345  C CA  . GLY A 1 47  ? -12.41429 9.80006  0.65743   1.000 22.13697  ? 47  GLY A CA  1 
ATOM   346  C C   . GLY A 1 47  ? -11.79988 9.66609  -0.72790  1.000 24.87569  ? 47  GLY A C   1 
ATOM   347  O O   . GLY A 1 47  ? -10.71558 9.08719  -0.87638  1.000 24.92450  ? 47  GLY A O   1 
ATOM   348  N N   . GLY A 1 48  ? -12.47906 10.16273 -1.75785  1.000 19.29045  ? 48  GLY A N   1 
ATOM   349  C CA  . GLY A 1 48  ? -11.89493 10.18816 -3.09163  1.000 14.05474  ? 48  GLY A CA  1 
ATOM   350  C C   . GLY A 1 48  ? -10.92066 11.35383 -3.22714  1.000 17.55803  ? 48  GLY A C   1 
ATOM   351  O O   . GLY A 1 48  ? -11.03748 12.38780 -2.54573  1.000 19.80107  ? 48  GLY A O   1 
ATOM   352  N N   . LYS A 1 49  ? -9.90590  11.14208 -4.08027  1.000 17.59851  ? 49  LYS A N   1 
ATOM   353  C CA  . LYS A 1 49  ? -8.92508  12.16453 -4.39125  1.000 16.29928  ? 49  LYS A CA  1 
ATOM   354  C C   . LYS A 1 49  ? -8.62922  12.18213 -5.89660  1.000 16.00711  ? 49  LYS A C   1 
ATOM   355  O O   . LYS A 1 49  ? -8.61601  11.14089 -6.56860  1.000 18.56230  ? 49  LYS A O   1 
ATOM   356  C CB  . LYS A 1 49  ? -7.63078  11.93717 -3.62599  1.000 14.09915  ? 49  LYS A CB  1 
ATOM   357  C CG  . LYS A 1 49  ? -7.85619  11.78367 -2.09604  1.000 18.39719  ? 49  LYS A CG  1 
ATOM   358  C CD  . LYS A 1 49  ? -6.52982  11.89769 -1.31342  1.000 19.66639  ? 49  LYS A CD  1 
ATOM   359  C CE  . LYS A 1 49  ? -6.67573  11.48845 0.18673   1.000 19.06908  ? 49  LYS A CE  1 
ATOM   360  N NZ  . LYS A 1 49  ? -7.57134  12.38502 0.91732   1.000 25.49166  ? 49  LYS A NZ  1 
ATOM   361  N N   . ILE A 1 50  ? -8.35338  13.37448 -6.38543  1.000 15.71659  ? 50  ILE A N   1 
ATOM   362  C CA  . ILE A 1 50  ? -7.86470  13.55542 -7.75804  1.000 18.99218  ? 50  ILE A CA  1 
ATOM   363  C C   . ILE A 1 50  ? -6.58843  14.37715 -7.68395  1.000 15.66444  ? 50  ILE A C   1 
ATOM   364  O O   . ILE A 1 50  ? -6.49737  15.30952 -6.87210  1.000 16.62215  ? 50  ILE A O   1 
ATOM   365  C CB  . ILE A 1 50  ? -8.93057  14.24915 -8.63809  1.000 19.99105  ? 50  ILE A CB  1 
ATOM   366  C CG1 . ILE A 1 50  ? -10.06033 13.25584 -8.91755  1.000 19.52134  ? 50  ILE A CG1 1 
ATOM   367  C CG2 . ILE A 1 50  ? -8.30157  14.87008 -9.92325  1.000 17.84127  ? 50  ILE A CG2 1 
ATOM   368  C CD1 . ILE A 1 50  ? -11.41909 14.01483 -9.30866  1.000 17.80682  ? 50  ILE A CD1 1 
ATOM   369  N N   . TRP A 1 51  ? -5.59268  14.00142 -8.48323  1.000 13.98794  ? 51  TRP A N   1 
ATOM   370  C CA  . TRP A 1 51  ? -4.32819  14.71662 -8.49015  1.000 16.21939  ? 51  TRP A CA  1 
ATOM   371  C C   . TRP A 1 51  ? -3.72147  14.58643 -9.86760  1.000 20.36665  ? 51  TRP A C   1 
ATOM   372  O O   . TRP A 1 51  ? -4.19416  13.80122 -10.71529 1.000 15.57557  ? 51  TRP A O   1 
ATOM   373  C CB  . TRP A 1 51  ? -3.35267  14.19763 -7.41695  1.000 16.42415  ? 51  TRP A CB  1 
ATOM   374  C CG  . TRP A 1 51  ? -2.81032  12.78179 -7.57784  1.000 16.92758  ? 51  TRP A CG  1 
ATOM   375  C CD1 . TRP A 1 51  ? -1.57176  12.42340 -8.01802  1.000 15.58223  ? 51  TRP A CD1 1 
ATOM   376  C CD2 . TRP A 1 51  ? -3.48518  11.56753 -7.24225  1.000 15.60354  ? 51  TRP A CD2 1 
ATOM   377  N NE1 . TRP A 1 51  ? -1.44118  11.04558 -8.00661  1.000 15.61297  ? 51  TRP A NE1 1 
ATOM   378  C CE2 . TRP A 1 51  ? -2.60625  10.50869 -7.51039  1.000 16.70764  ? 51  TRP A CE2 1 
ATOM   379  C CE3 . TRP A 1 51  ? -4.78231  11.27826 -6.76566  1.000 21.89680  ? 51  TRP A CE3 1 
ATOM   380  C CZ2 . TRP A 1 51  ? -2.97015  9.17154  -7.32725  1.000 18.28976  ? 51  TRP A CZ2 1 
ATOM   381  C CZ3 . TRP A 1 51  ? -5.14414  9.92980  -6.57440  1.000 23.83077  ? 51  TRP A CZ3 1 
ATOM   382  C CH2 . TRP A 1 51  ? -4.24526  8.91326  -6.84350  1.000 19.23424  ? 51  TRP A CH2 1 
ATOM   383  N N   . ALA A 1 52  ? -2.68155  15.38308 -10.08291 1.000 14.72608  ? 52  ALA A N   1 
ATOM   384  C CA  . ALA A 1 52  ? -1.92602  15.34377 -11.32969 1.000 14.91803  ? 52  ALA A CA  1 
ATOM   385  C C   . ALA A 1 52  ? -0.59696  14.69684 -11.05178 1.000 17.51209  ? 52  ALA A C   1 
ATOM   386  O O   . ALA A 1 52  ? -0.04270  14.84028 -9.96276  1.000 17.80018  ? 52  ALA A O   1 
ATOM   387  C CB  . ALA A 1 52  ? -1.70660  16.75586 -11.90713 1.000 16.73366  ? 52  ALA A CB  1 
ATOM   388  N N   . ARG A 1 53  ? -0.09325  13.96759 -12.03592 1.000 15.51840  ? 53  ARG A N   1 
ATOM   389  C CA  . ARG A 1 53  ? 1.25789   13.41995 -11.98529 1.000 16.15841  ? 53  ARG A CA  1 
ATOM   390  C C   . ARG A 1 53  ? 2.06891   14.07189 -13.09008 1.000 16.24503  ? 53  ARG A C   1 
ATOM   391  O O   . ARG A 1 53  ? 1.53126   14.34692 -14.16183 1.000 18.41588  ? 53  ARG A O   1 
ATOM   392  C CB  . ARG A 1 53  ? 1.23718   11.88234 -12.18651 1.000 15.24766  ? 53  ARG A CB  1 
ATOM   393  C CG  . ARG A 1 53  ? 0.48543   11.21036 -11.07169 1.000 14.29988  ? 53  ARG A CG  1 
ATOM   394  C CD  . ARG A 1 53  ? 0.14002   9.78149  -11.46341 1.000 14.64209  ? 53  ARG A CD  1 
ATOM   395  N NE  . ARG A 1 53  ? -0.80937  9.69874  -12.58737 1.000 17.96241  ? 53  ARG A NE  1 
ATOM   396  C CZ  . ARG A 1 53  ? -1.14452  8.52846  -13.13456 1.000 22.38575  ? 53  ARG A CZ  1 
ATOM   397  N NH1 . ARG A 1 53  ? -0.49498  7.39387  -12.81449 1.000 19.01381  ? 53  ARG A NH1 1 
ATOM   398  N NH2 . ARG A 1 53  ? -2.14913  8.47991  -14.00568 1.000 18.58796  ? 53  ARG A NH2 1 
ATOM   399  N N   . THR A 1 54  ? 3.37629   14.29252 -12.84894 1.000 17.31484  ? 54  THR A N   1 
ATOM   400  C CA  . THR A 1 54  ? 4.22804   14.96496 -13.82802 1.000 15.83279  ? 54  THR A CA  1 
ATOM   401  C C   . THR A 1 54  ? 5.39078   14.06379 -14.22490 1.000 19.88413  ? 54  THR A C   1 
ATOM   402  O O   . THR A 1 54  ? 5.80081   13.16590 -13.47220 1.000 18.90066  ? 54  THR A O   1 
ATOM   403  C CB  . THR A 1 54  ? 4.75509   16.30339 -13.35142 1.000 18.27071  ? 54  THR A CB  1 
ATOM   404  O OG1 . THR A 1 54  ? 5.53475   16.07834 -12.15932 1.000 19.62115  ? 54  THR A OG1 1 
ATOM   405  C CG2 . THR A 1 54  ? 3.55561   17.23578 -13.02835 1.000 18.52743  ? 54  THR A CG2 1 
ATOM   406  N N   . ASP A 1 55  ? 5.83807   14.26530 -15.47387 1.000 18.98759  ? 55  ASP A N   1 
ATOM   407  C CA  . ASP A 1 55  ? 7.01276   13.59116 -16.03610 1.000 20.85976  ? 55  ASP A CA  1 
ATOM   408  C C   . ASP A 1 55  ? 6.91979   12.07501 -15.89518 1.000 22.38738  ? 55  ASP A C   1 
ATOM   409  O O   . ASP A 1 55  ? 7.75839   11.42841 -15.25887 1.000 21.58090  ? 55  ASP A O   1 
ATOM   410  C CB  . ASP A 1 55  ? 8.28518   14.12205 -15.36527 1.000 22.48319  ? 55  ASP A CB  1 
ATOM   411  C CG  . ASP A 1 55  ? 8.57979   15.54343 -15.76685 1.000 30.56885  ? 55  ASP A CG  1 
ATOM   412  O OD1 . ASP A 1 55  ? 8.59636   15.80563 -16.98240 1.000 42.69019  ? 55  ASP A OD1 1 
ATOM   413  O OD2 . ASP A 1 55  ? 8.72321   16.39193 -14.87388 1.000 39.52136  ? 55  ASP A OD2 1 
ATOM   414  N N   . CYS A 1 56  ? 5.90674   11.51183 -16.54832 1.000 19.38341  ? 56  CYS A N   1 
ATOM   415  C CA  . CYS A 1 56  ? 5.64122   10.08804 -16.49253 1.000 18.61924  ? 56  CYS A CA  1 
ATOM   416  C C   . CYS A 1 56  ? 6.17169   9.42700  -17.76358 1.000 23.17600  ? 56  CYS A C   1 
ATOM   417  O O   . CYS A 1 56  ? 6.11266   9.99840  -18.85007 1.000 22.52836  ? 56  CYS A O   1 
ATOM   418  C CB  . CYS A 1 56  ? 4.14598   9.76017  -16.40028 1.000 21.38042  ? 56  CYS A CB  1 
ATOM   419  S SG  . CYS A 1 56  ? 3.31060   10.47774 -14.97609 1.000 20.48662  ? 56  CYS A SG  1 
ATOM   420  N N   . TYR A 1 57  ? 6.58217   8.17913  -17.62480 1.000 22.02042  ? 57  TYR A N   1 
ATOM   421  C CA  . TYR A 1 57  ? 6.85751   7.28840  -18.75252 1.000 22.93343  ? 57  TYR A CA  1 
ATOM   422  C C   . TYR A 1 57  ? 6.11253   6.00163  -18.49308 1.000 27.27658  ? 57  TYR A C   1 
ATOM   423  O O   . TYR A 1 57  ? 6.26548   5.41952  -17.42970 1.000 29.97609  ? 57  TYR A O   1 
ATOM   424  C CB  . TYR A 1 57  ? 8.35385   7.00553  -18.90047 1.000 25.62573  ? 57  TYR A CB  1 
ATOM   425  C CG  . TYR A 1 57  ? 9.08833   8.26131  -19.24805 1.000 38.77232  ? 57  TYR A CG  1 
ATOM   426  C CD1 . TYR A 1 57  ? 9.29324   8.64681  -20.59236 1.000 46.19896  ? 57  TYR A CD1 1 
ATOM   427  C CD2 . TYR A 1 57  ? 9.50129   9.13552  -18.24729 1.000 38.44093  ? 57  TYR A CD2 1 
ATOM   428  C CE1 . TYR A 1 57  ? 9.96316   9.86368  -20.90675 1.000 38.24858  ? 57  TYR A CE1 1 
ATOM   429  C CE2 . TYR A 1 57  ? 10.14474  10.33680 -18.55110 1.000 38.85559  ? 57  TYR A CE2 1 
ATOM   430  C CZ  . TYR A 1 57  ? 10.37367  10.68823 -19.87326 1.000 39.55848  ? 57  TYR A CZ  1 
ATOM   431  O OH  . TYR A 1 57  ? 11.00334  11.88666 -20.08539 1.000 50.56822  ? 57  TYR A OH  1 
ATOM   432  N N   . PHE A 1 58  ? 5.31477   5.54809  -19.46797 1.000 24.75917  ? 58  PHE A N   1 
ATOM   433  C CA  . PHE A 1 58  ? 4.57995   4.31167  -19.33534 1.000 23.89733  ? 58  PHE A CA  1 
ATOM   434  C C   . PHE A 1 58  ? 4.79706   3.46697  -20.58495 1.000 35.15488  ? 58  PHE A C   1 
ATOM   435  O O   . PHE A 1 58  ? 4.90507   3.99989  -21.68675 1.000 35.51731  ? 58  PHE A O   1 
ATOM   436  C CB  . PHE A 1 58  ? 3.06658   4.56500  -19.14895 1.000 24.61829  ? 58  PHE A CB  1 
ATOM   437  C CG  . PHE A 1 58  ? 2.71810   5.24281  -17.86087 1.000 25.49990  ? 58  PHE A CG  1 
ATOM   438  C CD1 . PHE A 1 58  ? 2.80184   4.53522  -16.66904 1.000 23.62670  ? 58  PHE A CD1 1 
ATOM   439  C CD2 . PHE A 1 58  ? 2.28295   6.57257  -17.83576 1.000 22.61203  ? 58  PHE A CD2 1 
ATOM   440  C CE1 . PHE A 1 58  ? 2.49615   5.15143  -15.42198 1.000 22.43093  ? 58  PHE A CE1 1 
ATOM   441  C CE2 . PHE A 1 58  ? 1.94452   7.19259  -16.61381 1.000 23.34493  ? 58  PHE A CE2 1 
ATOM   442  C CZ  . PHE A 1 58  ? 2.05338   6.47597  -15.39695 1.000 22.61326  ? 58  PHE A CZ  1 
ATOM   443  N N   . ASP A 1 59  ? 4.86305   2.16053  -20.40727 1.000 40.42155  ? 59  ASP A N   1 
ATOM   444  C CA  . ASP A 1 59  ? 4.96168   1.25653  -21.54489 1.000 39.58287  ? 59  ASP A CA  1 
ATOM   445  C C   . ASP A 1 59  ? 3.55877   0.93973  -22.07109 1.000 49.93811  ? 59  ASP A C   1 
ATOM   446  O O   . ASP A 1 59  ? 2.54718   1.47654  -21.59876 1.000 34.56191  ? 59  ASP A O   1 
ATOM   447  C CB  . ASP A 1 59  ? 5.75199   0.00302  -21.15439 1.000 30.72823  ? 59  ASP A CB  1 
ATOM   448  C CG  . ASP A 1 59  ? 5.04165   -0.87446 -20.13155 1.000 37.03178  ? 59  ASP A CG  1 
ATOM   449  O OD1 . ASP A 1 59  ? 3.80207   -0.78647 -19.96839 1.000 41.18835  ? 59  ASP A OD1 1 
ATOM   450  O OD2 . ASP A 1 59  ? 5.74191   -1.67190 -19.46011 1.000 50.84052  ? 59  ASP A OD2 1 
ATOM   451  N N   . ASP A 1 60  ? 3.48579   0.02355  -23.04348 1.000 54.06724  ? 60  ASP A N   1 
ATOM   452  C CA  . ASP A 1 60  ? 2.20553   -0.34877 -23.62554 1.000 52.95747  ? 60  ASP A CA  1 
ATOM   453  C C   . ASP A 1 60  ? 1.26975   -1.00306 -22.62403 1.000 44.18037  ? 60  ASP A C   1 
ATOM   454  O O   . ASP A 1 60  ? 0.05273   -0.90884 -22.79604 1.000 51.87671  ? 60  ASP A O   1 
ATOM   455  C CB  . ASP A 1 60  ? 2.42548   -1.27325 -24.81766 1.000 69.87790  ? 60  ASP A CB  1 
ATOM   456  C CG  . ASP A 1 60  ? 3.01634   -0.54187 -26.00844 1.000 94.06232  ? 60  ASP A CG  1 
ATOM   457  O OD1 . ASP A 1 60  ? 2.78154   0.68730  -26.14358 1.000 80.30321  ? 60  ASP A OD1 1 
ATOM   458  O OD2 . ASP A 1 60  ? 3.71905   -1.19555 -26.80957 1.000 117.73407 ? 60  ASP A OD2 1 
ATOM   459  N N   . SER A 1 61  ? 1.79577   -1.64707 -21.57877 1.000 45.42547  ? 61  SER A N   1 
ATOM   460  C CA  . SER A 1 61  ? 0.94371   -2.25025 -20.56085 1.000 42.68328  ? 61  SER A CA  1 
ATOM   461  C C   . SER A 1 61  ? 0.49193   -1.27670 -19.44934 1.000 47.52876  ? 61  SER A C   1 
ATOM   462  O O   . SER A 1 61  ? -0.19729  -1.70489 -18.51749 1.000 40.62758  ? 61  SER A O   1 
ATOM   463  C CB  . SER A 1 61  ? 1.66498   -3.45475 -19.94567 1.000 48.47759  ? 61  SER A CB  1 
ATOM   464  O OG  . SER A 1 61  ? 2.71964   -3.04831 -19.06950 1.000 60.27708  ? 61  SER A OG  1 
ATOM   465  N N   . GLY A 1 62  ? 0.83086   0.01143  -19.51832 1.000 37.47478  ? 62  GLY A N   1 
ATOM   466  C CA  . GLY A 1 62  ? 0.38240   0.94309  -18.49152 1.000 34.54094  ? 62  GLY A CA  1 
ATOM   467  C C   . GLY A 1 62  ? 1.22777   0.93669  -17.23814 1.000 33.85326  ? 62  GLY A C   1 
ATOM   468  O O   . GLY A 1 62  ? 0.75563   1.31831  -16.16070 1.000 31.77749  ? 62  GLY A O   1 
ATOM   469  N N   . SER A 1 63  ? 2.48060   0.52601  -17.35306 1.000 30.73366  ? 63  SER A N   1 
ATOM   470  C CA  . SER A 1 63  ? 3.37077   0.36514  -16.22516 1.000 32.05707  ? 63  SER A CA  1 
ATOM   471  C C   . SER A 1 63  ? 4.55656   1.29049  -16.46026 1.000 31.25939  ? 63  SER A C   1 
ATOM   472  O O   . SER A 1 63  ? 5.00895   1.46301  -17.59446 1.000 28.84726  ? 63  SER A O   1 
ATOM   473  C CB  . SER A 1 63  ? 3.77949   -1.10025 -16.12138 1.000 33.76437  ? 63  SER A CB  1 
ATOM   474  O OG  . SER A 1 63  ? 4.47383   -1.33663 -14.93304 1.000 53.68976  ? 63  SER A OG  1 
ATOM   475  N N   . GLY A 1 64  ? 5.02678   1.94784  -15.40734 1.000 26.45737  ? 64  GLY A N   1 
ATOM   476  C CA  . GLY A 1 64  ? 6.04528   2.94443  -15.64551 1.000 22.88935  ? 64  GLY A CA  1 
ATOM   477  C C   . GLY A 1 64  ? 6.41627   3.71329  -14.40066 1.000 20.71744  ? 64  GLY A C   1 
ATOM   478  O O   . GLY A 1 64  ? 6.43394   3.12611  -13.32588 1.000 23.84580  ? 64  GLY A O   1 
ATOM   479  N N   . ILE A 1 65  ? 6.67161   5.01952  -14.51983 1.000 22.81353  ? 65  ILE A N   1 
ATOM   480  C CA  A ILE A 1 65  ? 7.13576   5.82137  -13.38638 0.517 19.98018  ? 65  ILE A CA  1 
ATOM   481  C CA  B ILE A 1 65  ? 7.07963   5.81709  -13.37213 0.483 19.95846  ? 65  ILE A CA  1 
ATOM   482  C C   . ILE A 1 65  ? 6.77012   7.27885  -13.65866 1.000 21.18861  ? 65  ILE A C   1 
ATOM   483  O O   . ILE A 1 65  ? 6.74574   7.71333  -14.81249 1.000 22.08222  ? 65  ILE A O   1 
ATOM   484  C CB  A ILE A 1 65  ? 8.66235   5.62840  -13.18270 0.517 20.66293  ? 65  ILE A CB  1 
ATOM   485  C CB  B ILE A 1 65  ? 8.57719   5.61355  -13.03501 0.483 20.38438  ? 65  ILE A CB  1 
ATOM   486  C CG1 A ILE A 1 65  ? 9.20808   6.47160  -12.02104 0.517 19.88939  ? 65  ILE A CG1 1 
ATOM   487  C CG1 B ILE A 1 65  ? 8.85782   6.26230  -11.68340 0.483 23.36130  ? 65  ILE A CG1 1 
ATOM   488  C CG2 A ILE A 1 65  ? 9.42638   5.97876  -14.48036 0.517 23.57290  ? 65  ILE A CG2 1 
ATOM   489  C CG2 B ILE A 1 65  ? 9.48082   6.21735  -14.13770 0.483 24.94771  ? 65  ILE A CG2 1 
ATOM   490  C CD1 A ILE A 1 65  ? 8.85659   5.96804  -10.58705 0.517 22.41876  ? 65  ILE A CD1 1 
ATOM   491  C CD1 B ILE A 1 65  ? 10.22647  6.03663  -11.13840 0.483 17.76628  ? 65  ILE A CD1 1 
ATOM   492  N N   . CYS A 1 66  ? 6.46969   8.03552  -12.58803 1.000 19.73336  ? 66  CYS A N   1 
ATOM   493  C CA  . CYS A 1 66  ? 6.24701   9.48247  -12.67848 1.000 19.84857  ? 66  CYS A CA  1 
ATOM   494  C C   . CYS A 1 66  ? 7.11642   10.12559 -11.60349 1.000 17.59948  ? 66  CYS A C   1 
ATOM   495  O O   . CYS A 1 66  ? 7.38206   9.52105  -10.56428 1.000 21.64066  ? 66  CYS A O   1 
ATOM   496  C CB  . CYS A 1 66  ? 4.76289   9.89516  -12.42937 1.000 17.68480  ? 66  CYS A CB  1 
ATOM   497  S SG  . CYS A 1 66  ? 3.56342   9.12605  -13.49077 1.000 20.39167  ? 66  CYS A SG  1 
ATOM   498  N N   . LYS A 1 67  ? 7.54371   11.35397 -11.85137 1.000 19.91443  ? 67  LYS A N   1 
ATOM   499  C CA  . LYS A 1 67  ? 8.37091   12.08288 -10.90846 1.000 20.72172  ? 67  LYS A CA  1 
ATOM   500  C C   . LYS A 1 67  ? 7.58216   12.71420 -9.78810  1.000 23.42190  ? 67  LYS A C   1 
ATOM   501  O O   . LYS A 1 67  ? 8.13268   12.91320 -8.69577  1.000 21.25517  ? 67  LYS A O   1 
ATOM   502  C CB  . LYS A 1 67  ? 9.17722   13.15495 -11.64794 1.000 19.22553  ? 67  LYS A CB  1 
ATOM   503  C CG  . LYS A 1 67  ? 10.17775  12.56447 -12.57282 1.000 22.90730  ? 67  LYS A CG  1 
ATOM   504  C CD  . LYS A 1 67  ? 11.32321  13.52044 -12.71283 1.000 25.00310  ? 67  LYS A CD  1 
ATOM   505  C CE  . LYS A 1 67  ? 12.33863  12.93737 -13.68358 1.000 29.65895  ? 67  LYS A CE  1 
ATOM   506  N NZ  . LYS A 1 67  ? 13.21199  14.04087 -14.17686 1.000 42.22899  ? 67  LYS A NZ  1 
ATOM   507  N N   . THR A 1 68  ? 6.29549   13.00807 -9.98273  1.000 17.00978  ? 68  THR A N   1 
ATOM   508  C CA  . THR A 1 68  ? 5.46308   13.38673 -8.83816  1.000 16.66317  ? 68  THR A CA  1 
ATOM   509  C C   . THR A 1 68  ? 4.17831   12.58956 -8.90258  1.000 18.69164  ? 68  THR A C   1 
ATOM   510  O O   . THR A 1 68  ? 3.67497   12.32090 -9.99472  1.000 17.14505  ? 68  THR A O   1 
ATOM   511  C CB  . THR A 1 68  ? 5.09765   14.90696 -8.77488  1.000 21.47533  ? 68  THR A CB  1 
ATOM   512  O OG1 . THR A 1 68  ? 4.30389   15.29458 -9.91401  1.000 17.43343  ? 68  THR A OG1 1 
ATOM   513  C CG2 . THR A 1 68  ? 6.36644   15.78873 -8.65434  1.000 16.64052  ? 68  THR A CG2 1 
ATOM   514  N N   . GLY A 1 69  ? 3.65873   12.20329 -7.74387  1.000 16.25155  ? 69  GLY A N   1 
ATOM   515  C CA  . GLY A 1 69  ? 2.35757   11.55202 -7.70258  1.000 18.19837  ? 69  GLY A CA  1 
ATOM   516  C C   . GLY A 1 69  ? 2.28317   10.11613 -8.15593  1.000 18.30911  ? 69  GLY A C   1 
ATOM   517  O O   . GLY A 1 69  ? 1.17428   9.61166  -8.32017  1.000 18.42588  ? 69  GLY A O   1 
ATOM   518  N N   . ASP A 1 70  ? 3.40637   9.42149  -8.31873  1.000 17.38851  ? 70  ASP A N   1 
ATOM   519  C CA  . ASP A 1 70  ? 3.36750   8.05447  -8.84506  1.000 16.77246  ? 70  ASP A CA  1 
ATOM   520  C C   . ASP A 1 70  ? 2.54424   7.15719  -7.91357  1.000 19.36394  ? 70  ASP A C   1 
ATOM   521  O O   . ASP A 1 70  ? 2.70029   7.22616  -6.68642  1.000 19.81265  ? 70  ASP A O   1 
ATOM   522  C CB  . ASP A 1 70  ? 4.79712   7.52012  -8.95955  1.000 18.54619  ? 70  ASP A CB  1 
ATOM   523  C CG  . ASP A 1 70  ? 4.86954   6.17232  -9.65454  1.000 24.43317  ? 70  ASP A CG  1 
ATOM   524  O OD1 . ASP A 1 70  ? 4.67198   6.13734  -10.87525 1.000 28.61493  ? 70  ASP A OD1 1 
ATOM   525  O OD2 . ASP A 1 70  ? 5.08518   5.16704  -8.94713  1.000 29.16968  ? 70  ASP A OD2 1 
ATOM   526  N N   . CYS A 1 71  ? 1.66668   6.32682  -8.48375  1.000 19.00305  ? 71  CYS A N   1 
ATOM   527  C CA  . CYS A 1 71  ? 0.80241   5.43324  -7.69000  1.000 21.17140  ? 71  CYS A CA  1 
ATOM   528  C C   . CYS A 1 71  ? 1.22944   3.98677  -7.97158  1.000 22.76813  ? 71  CYS A C   1 
ATOM   529  O O   . CYS A 1 71  ? 0.56907   3.24272  -8.69489  1.000 25.95294  ? 71  CYS A O   1 
ATOM   530  C CB  . CYS A 1 71  ? -0.70664  5.65929  -8.01519  1.000 18.39065  ? 71  CYS A CB  1 
ATOM   531  S SG  . CYS A 1 71  ? -1.05141  5.30799  -9.78850  1.000 22.94646  ? 71  CYS A SG  1 
ATOM   532  N N   . GLY A 1 72  ? 2.40167   3.61905  -7.45753  1.000 23.82235  ? 72  GLY A N   1 
ATOM   533  C CA  . GLY A 1 72  ? 2.90188   2.25527  -7.64050  1.000 23.28503  ? 72  GLY A CA  1 
ATOM   534  C C   . GLY A 1 72  ? 3.21337   1.91430  -9.07157  1.000 26.36236  ? 72  GLY A C   1 
ATOM   535  O O   . GLY A 1 72  ? 3.04364   0.76799  -9.48249  1.000 28.10740  ? 72  GLY A O   1 
ATOM   536  N N   . GLY A 1 73  ? 3.57479   2.89751  -9.87098  1.000 22.08151  ? 73  GLY A N   1 
ATOM   537  C CA  . GLY A 1 73  ? 4.02085   2.64238  -11.22034 1.000 28.56533  ? 73  GLY A CA  1 
ATOM   538  C C   . GLY A 1 73  ? 2.94076   2.37441  -12.24782 1.000 26.57172  ? 73  GLY A C   1 
ATOM   539  O O   . GLY A 1 73  ? 3.27187   1.94790  -13.35204 1.000 28.95037  ? 73  GLY A O   1 
ATOM   540  N N   . LEU A 1 74  ? 1.67368   2.61577  -11.94256 1.000 22.98333  ? 74  LEU A N   1 
ATOM   541  C CA  . LEU A 1 74  ? 0.57259   2.31100  -12.86098 1.000 24.69742  ? 74  LEU A CA  1 
ATOM   542  C C   . LEU A 1 74  ? 0.03621   3.58136  -13.50704 1.000 24.00453  ? 74  LEU A C   1 
ATOM   543  O O   . LEU A 1 74  ? -0.06623  4.62301  -12.85385 1.000 23.90793  ? 74  LEU A O   1 
ATOM   544  C CB  . LEU A 1 74  ? -0.58329  1.63397  -12.13176 1.000 24.17023  ? 74  LEU A CB  1 
ATOM   545  C CG  . LEU A 1 74  ? -0.18721  0.35069  -11.39699 1.000 36.42065  ? 74  LEU A CG  1 
ATOM   546  C CD1 . LEU A 1 74  ? -1.39872  -0.29480 -10.77848 1.000 30.62975  ? 74  LEU A CD1 1 
ATOM   547  C CD2 . LEU A 1 74  ? 0.49910   -0.55807 -12.35117 1.000 30.27081  ? 74  LEU A CD2 1 
ATOM   548  N N   . LEU A 1 75  ? -0.32685  3.48188  -14.77909 1.000 19.33859  ? 75  LEU A N   1 
ATOM   549  C CA  . LEU A 1 75  ? -1.08572  4.54749  -15.41773 1.000 25.67949  ? 75  LEU A CA  1 
ATOM   550  C C   . LEU A 1 75  ? -2.43742  4.67754  -14.75687 1.000 23.69098  ? 75  LEU A C   1 
ATOM   551  O O   . LEU A 1 75  ? -2.86305  5.77808  -14.37931 1.000 24.27086  ? 75  LEU A O   1 
ATOM   552  C CB  . LEU A 1 75  ? -1.25544  4.25610  -16.91499 1.000 28.05977  ? 75  LEU A CB  1 
ATOM   553  C CG  . LEU A 1 75  ? -2.18565  5.21485  -17.67628 1.000 31.67161  ? 75  LEU A CG  1 
ATOM   554  C CD1 . LEU A 1 75  ? -1.74900  6.70485  -17.58492 1.000 27.11370  ? 75  LEU A CD1 1 
ATOM   555  C CD2 . LEU A 1 75  ? -2.24151  4.76598  -19.12583 1.000 33.97206  ? 75  LEU A CD2 1 
ATOM   556  N N   . ARG A 1 76  ? -3.10850  3.54228  -14.53489 1.000 22.55618  ? 76  ARG A N   1 
ATOM   557  C CA  . ARG A 1 76  ? -4.44015  3.55099  -13.93905 1.000 24.13023  ? 76  ARG A CA  1 
ATOM   558  C C   . ARG A 1 76  ? -4.29962  3.33723  -12.44626 1.000 27.55393  ? 76  ARG A C   1 
ATOM   559  O O   . ARG A 1 76  ? -4.11698  2.21693  -11.97699 1.000 30.13288  ? 76  ARG A O   1 
ATOM   560  C CB  . ARG A 1 76  ? -5.33088  2.49417  -14.61525 1.000 25.79272  ? 76  ARG A CB  1 
ATOM   561  C CG  . ARG A 1 76  ? -5.72153  2.94312  -16.02529 1.000 30.77453  ? 76  ARG A CG  1 
ATOM   562  C CD  . ARG A 1 76  ? -6.51411  1.86700  -16.79159 1.000 40.98058  ? 76  ARG A CD  1 
ATOM   563  N NE  . ARG A 1 76  ? -5.54998  0.88169  -17.24397 1.000 70.36979  ? 76  ARG A NE  1 
ATOM   564  C CZ  . ARG A 1 76  ? -4.80282  1.01392  -18.33281 1.000 81.30527  ? 76  ARG A CZ  1 
ATOM   565  N NH1 . ARG A 1 76  ? -5.08438  1.92228  -19.25983 1.000 78.69528  ? 76  ARG A NH1 1 
ATOM   566  N NH2 . ARG A 1 76  ? -3.72741  0.23974  -18.47910 1.000 68.75966  ? 76  ARG A NH2 1 
ATOM   567  N N   . CYS A 1 77  ? -4.36988  4.42469  -11.67746 1.000 22.23143  ? 77  CYS A N   1 
ATOM   568  C CA  . CYS A 1 77  ? -4.11589  4.35383  -10.24266 1.000 20.67511  ? 77  CYS A CA  1 
ATOM   569  C C   . CYS A 1 77  ? -5.19902  3.61337  -9.47004  1.000 32.28861  ? 77  CYS A C   1 
ATOM   570  O O   . CYS A 1 77  ? -6.38103  3.94618  -9.56661  1.000 30.70379  ? 77  CYS A O   1 
ATOM   571  C CB  . CYS A 1 77  ? -3.99182  5.76855  -9.64763  1.000 23.71853  ? 77  CYS A CB  1 
ATOM   572  S SG  . CYS A 1 77  ? -2.51922  6.60443  -10.26570 1.000 22.86166  ? 77  CYS A SG  1 
ATOM   573  N N   . LYS A 1 78  ? -4.78078  2.67570  -8.62730  1.000 23.81862  ? 78  LYS A N   1 
ATOM   574  C CA  . LYS A 1 78  ? -5.68266  2.04338  -7.66062  1.000 26.87450  ? 78  LYS A CA  1 
ATOM   575  C C   . LYS A 1 78  ? -5.44282  2.54686  -6.26030  1.000 31.20251  ? 78  LYS A C   1 
ATOM   576  O O   . LYS A 1 78  ? -6.32455  2.40842  -5.40445  1.000 36.51480  ? 78  LYS A O   1 
ATOM   577  C CB  . LYS A 1 78  ? -5.54208  0.50501  -7.68055  1.000 33.28401  ? 78  LYS A CB  1 
ATOM   578  N N   . ARG A 1 79  ? -4.27124  3.12775  -6.00625  1.000 27.88503  ? 79  ARG A N   1 
ATOM   579  C CA  . ARG A 1 79  ? -3.87000  3.57798  -4.68171  1.000 25.96283  ? 79  ARG A CA  1 
ATOM   580  C C   . ARG A 1 79  ? -3.52112  5.05921  -4.78629  1.000 22.71666  ? 79  ARG A C   1 
ATOM   581  O O   . ARG A 1 79  ? -3.43178  5.61211  -5.89296  1.000 24.31535  ? 79  ARG A O   1 
ATOM   582  C CB  . ARG A 1 79  ? -2.65689  2.77359  -4.16067  1.000 24.33087  ? 79  ARG A CB  1 
ATOM   583  N N   . PHE A 1 80  ? -3.29098  5.71041  -3.63637  1.000 19.98245  ? 80  PHE A N   1 
ATOM   584  C CA  . PHE A 1 80  ? -2.91272  7.12242  -3.72074  1.000 25.59927  ? 80  PHE A CA  1 
ATOM   585  C C   . PHE A 1 80  ? -1.46032  7.28519  -4.17607  1.000 27.99387  ? 80  PHE A C   1 
ATOM   586  O O   . PHE A 1 80  ? -0.65204  6.34556  -4.19455  1.000 25.13295  ? 80  PHE A O   1 
ATOM   587  C CB  . PHE A 1 80  ? -3.12577  7.83185  -2.38587  1.000 21.72656  ? 80  PHE A CB  1 
ATOM   588  C CG  . PHE A 1 80  ? -4.58794  7.92878  -1.95570  1.000 21.09728  ? 80  PHE A CG  1 
ATOM   589  C CD1 . PHE A 1 80  ? -5.59971  8.28900  -2.86026  1.000 23.92575  ? 80  PHE A CD1 1 
ATOM   590  C CD2 . PHE A 1 80  ? -4.93839  7.65789  -0.64329  1.000 26.08576  ? 80  PHE A CD2 1 
ATOM   591  C CE1 . PHE A 1 80  ? -6.93422  8.37212  -2.42193  1.000 23.66002  ? 80  PHE A CE1 1 
ATOM   592  C CE2 . PHE A 1 80  ? -6.25533  7.76533  -0.20360  1.000 25.79436  ? 80  PHE A CE2 1 
ATOM   593  C CZ  . PHE A 1 80  ? -7.24204  8.09654  -1.11302  1.000 28.34548  ? 80  PHE A CZ  1 
ATOM   594  N N   . GLY A 1 81  ? -1.13920  8.51312  -4.56243  1.000 18.85722  ? 81  GLY A N   1 
ATOM   595  C CA  . GLY A 1 81  ? 0.12552   8.79021  -5.20213  1.000 19.25957  ? 81  GLY A CA  1 
ATOM   596  C C   . GLY A 1 81  ? 1.19426   9.26781  -4.22384  1.000 15.34618  ? 81  GLY A C   1 
ATOM   597  O O   . GLY A 1 81  ? 0.94070   9.75010  -3.11630  1.000 19.18935  ? 81  GLY A O   1 
ATOM   598  N N   . ARG A 1 82  ? 2.43140   9.12051  -4.65769  1.000 17.99067  ? 82  ARG A N   1 
ATOM   599  C CA  . ARG A 1 82  ? 3.57828   9.54568  -3.84609  1.000 18.22629  ? 82  ARG A CA  1 
ATOM   600  C C   . ARG A 1 82  ? 3.70347   11.07146 -3.80813  1.000 19.05892  ? 82  ARG A C   1 
ATOM   601  O O   . ARG A 1 82  ? 3.67211   11.72324 -4.86090  1.000 19.03157  ? 82  ARG A O   1 
ATOM   602  C CB  . ARG A 1 82  ? 4.84591   8.92711  -4.46090  1.000 19.66919  ? 82  ARG A CB  1 
ATOM   603  C CG  . ARG A 1 82  ? 6.11764   9.20879  -3.69884  1.000 28.87191  ? 82  ARG A CG  1 
ATOM   604  C CD  . ARG A 1 82  ? 7.22290   8.39688  -4.39301  1.000 34.78061  ? 82  ARG A CD  1 
ATOM   605  N NE  . ARG A 1 82  ? 8.39727   8.32632  -3.54342  1.000 45.64025  ? 82  ARG A NE  1 
ATOM   606  C CZ  . ARG A 1 82  ? 9.42153   9.16197  -3.62190  1.000 33.30254  ? 82  ARG A CZ  1 
ATOM   607  N NH1 . ARG A 1 82  ? 9.49838   10.07680 -4.57598  1.000 40.24081  ? 82  ARG A NH1 1 
ATOM   608  N NH2 . ARG A 1 82  ? 10.36428  9.11759  -2.69366  1.000 41.20880  ? 82  ARG A NH2 1 
ATOM   609  N N   . PRO A 1 83  ? 3.88827   11.67893 -2.63227  1.000 17.56290  ? 83  PRO A N   1 
ATOM   610  C CA  . PRO A 1 83  ? 4.04975   13.14530 -2.55849  1.000 15.70451  ? 83  PRO A CA  1 
ATOM   611  C C   . PRO A 1 83  ? 5.27454   13.57940 -3.33926  1.000 15.80796  ? 83  PRO A C   1 
ATOM   612  O O   . PRO A 1 83  ? 6.21317   12.79552 -3.49154  1.000 19.44613  ? 83  PRO A O   1 
ATOM   613  C CB  . PRO A 1 83  ? 4.24930   13.40773 -1.05163  1.000 18.55241  ? 83  PRO A CB  1 
ATOM   614  C CG  . PRO A 1 83  ? 3.60201   12.24635 -0.41429  1.000 21.21717  ? 83  PRO A CG  1 
ATOM   615  C CD  . PRO A 1 83  ? 3.80081   11.06332 -1.29903  1.000 20.54785  ? 83  PRO A CD  1 
ATOM   616  N N   . PRO A 1 84  ? 5.33971   14.82340 -3.77903  1.000 17.39635  ? 84  PRO A N   1 
ATOM   617  C CA  . PRO A 1 84  ? 4.38505   15.89866 -3.53499  1.000 16.43453  ? 84  PRO A CA  1 
ATOM   618  C C   . PRO A 1 84  ? 3.20096   15.84721 -4.50605  1.000 14.04158  ? 84  PRO A C   1 
ATOM   619  O O   . PRO A 1 84  ? 3.39236   15.61279 -5.71468  1.000 19.95942  ? 84  PRO A O   1 
ATOM   620  C CB  . PRO A 1 84  ? 5.24305   17.17095 -3.73703  1.000 14.77944  ? 84  PRO A CB  1 
ATOM   621  C CG  . PRO A 1 84  ? 6.37697   16.75013 -4.71774  1.000 18.17096  ? 84  PRO A CG  1 
ATOM   622  C CD  . PRO A 1 84  ? 6.57050   15.28206 -4.48781  1.000 21.37934  ? 84  PRO A CD  1 
ATOM   623  N N   . THR A 1 85  ? 1.98687   16.06699 -4.01843  1.000 15.11809  ? 85  THR A N   1 
ATOM   624  C CA  . THR A 1 85  ? 0.77867   16.05174 -4.84498  1.000 15.44130  ? 85  THR A CA  1 
ATOM   625  C C   . THR A 1 85  ? -0.18495  17.05917 -4.26759  1.000 17.53098  ? 85  THR A C   1 
ATOM   626  O O   . THR A 1 85  ? -0.66185  16.85534 -3.14028  1.000 18.09752  ? 85  THR A O   1 
ATOM   627  C CB  . THR A 1 85  ? 0.08173   14.68907 -4.80623  1.000 18.56423  ? 85  THR A CB  1 
ATOM   628  O OG1 . THR A 1 85  ? -0.15359  14.31781 -3.43870  1.000 19.31117  ? 85  THR A OG1 1 
ATOM   629  C CG2 . THR A 1 85  ? 0.88733   13.59738 -5.48887  1.000 18.01631  ? 85  THR A CG2 1 
ATOM   630  N N   . THR A 1 86  ? -0.52562  18.08054 -5.02803  1.000 14.41440  ? 86  THR A N   1 
ATOM   631  C CA  . THR A 1 86  ? -1.68014  18.90413 -4.68402  1.000 17.52951  ? 86  THR A CA  1 
ATOM   632  C C   . THR A 1 86  ? -2.93307  18.01492 -4.78437  1.000 15.99573  ? 86  THR A C   1 
ATOM   633  O O   . THR A 1 86  ? -3.05217  17.25162 -5.73225  1.000 17.59053  ? 86  THR A O   1 
ATOM   634  C CB  . THR A 1 86  ? -1.82362  20.08661 -5.65914  1.000 15.80073  ? 86  THR A CB  1 
ATOM   635  O OG1 . THR A 1 86  ? -0.54033  20.62284 -5.93949  1.000 15.76815  ? 86  THR A OG1 1 
ATOM   636  C CG2 . THR A 1 86  ? -2.74811  21.16645 -5.03463  1.000 18.74235  ? 86  THR A CG2 1 
ATOM   637  N N   . LEU A 1 87  ? -3.82033  18.06587 -3.79231  1.000 15.04804  ? 87  LEU A N   1 
ATOM   638  C CA  . LEU A 1 87  ? -4.93035  17.10243 -3.73934  1.000 14.63251  ? 87  LEU A CA  1 
ATOM   639  C C   . LEU A 1 87  ? -6.28182  17.77093 -3.80742  1.000 18.39286  ? 87  LEU A C   1 
ATOM   640  O O   . LEU A 1 87  ? -6.58944  18.63895 -2.97879  1.000 18.71985  ? 87  LEU A O   1 
ATOM   641  C CB  . LEU A 1 87  ? -4.88816  16.24864 -2.46034  1.000 18.37184  ? 87  LEU A CB  1 
ATOM   642  C CG  . LEU A 1 87  ? -3.67861  15.31371 -2.38628  1.000 16.87700  ? 87  LEU A CG  1 
ATOM   643  C CD1 . LEU A 1 87  ? -3.65364  14.70709 -0.97120  1.000 18.65415  ? 87  LEU A CD1 1 
ATOM   644  C CD2 . LEU A 1 87  ? -3.75947  14.24173 -3.46733  1.000 21.51536  ? 87  LEU A CD2 1 
ATOM   645  N N   . ALA A 1 88  ? -7.12588  17.31941 -4.75211  1.000 15.91349  ? 88  ALA A N   1 
ATOM   646  C CA  . ALA A 1 88  ? -8.54717  17.61868 -4.69511  1.000 14.74917  ? 88  ALA A CA  1 
ATOM   647  C C   . ALA A 1 88  ? -9.21341  16.47423 -3.93829  1.000 17.84994  ? 88  ALA A C   1 
ATOM   648  O O   . ALA A 1 88  ? -9.06318  15.32391 -4.32521  1.000 18.55507  ? 88  ALA A O   1 
ATOM   649  C CB  . ALA A 1 88  ? -9.16243  17.73361 -6.08799  1.000 14.65791  ? 88  ALA A CB  1 
ATOM   650  N N   . GLU A 1 89  ? -9.92675  16.78708 -2.86441  1.000 13.24452  ? 89  GLU A N   1 
ATOM   651  C CA  . GLU A 1 89  ? -10.46338 15.73931 -2.00450  1.000 16.52956  ? 89  GLU A CA  1 
ATOM   652  C C   . GLU A 1 89  ? -11.96854 15.87740 -1.89388  1.000 16.68905  ? 89  GLU A C   1 
ATOM   653  O O   . GLU A 1 89  ? -12.48299 17.00369 -1.83841  1.000 16.88066  ? 89  GLU A O   1 
ATOM   654  C CB  . GLU A 1 89  ? -9.86901  15.85418 -0.59102  1.000 15.07103  ? 89  GLU A CB  1 
ATOM   655  C CG  . GLU A 1 89  ? -8.32254  15.80568 -0.61019  1.000 19.82512  ? 89  GLU A CG  1 
ATOM   656  C CD  . GLU A 1 89  ? -7.73346  15.82384 0.82030   1.000 21.24934  ? 89  GLU A CD  1 
ATOM   657  O OE1 . GLU A 1 89  ? -8.13375  16.67688 1.63300   1.000 18.46633  ? 89  GLU A OE1 1 
ATOM   658  O OE2 . GLU A 1 89  ? -6.90657  14.98400 1.09460   1.000 20.43617  ? 89  GLU A OE2 1 
ATOM   659  N N   . PHE A 1 90  ? -12.65999 14.72765 -1.78024  1.000 19.85686  ? 90  PHE A N   1 
ATOM   660  C CA  . PHE A 1 90  ? -14.11061 14.84695 -1.76268  1.000 21.31876  ? 90  PHE A CA  1 
ATOM   661  C C   . PHE A 1 90  ? -14.75191 13.61689 -1.13679  1.000 18.89619  ? 90  PHE A C   1 
ATOM   662  O O   . PHE A 1 90  ? -14.28804 12.48433 -1.29940  1.000 20.38861  ? 90  PHE A O   1 
ATOM   663  C CB  . PHE A 1 90  ? -14.66107 15.08903 -3.18172  1.000 18.08646  ? 90  PHE A CB  1 
ATOM   664  C CG  . PHE A 1 90  ? -14.13888 14.10587 -4.20186  1.000 14.28685  ? 90  PHE A CG  1 
ATOM   665  C CD1 . PHE A 1 90  ? -14.74980 12.88936 -4.39433  1.000 19.94584  ? 90  PHE A CD1 1 
ATOM   666  C CD2 . PHE A 1 90  ? -12.98237 14.37777 -4.91655  1.000 18.13370  ? 90  PHE A CD2 1 
ATOM   667  C CE1 . PHE A 1 90  ? -14.26864 12.00046 -5.32501  1.000 24.33619  ? 90  PHE A CE1 1 
ATOM   668  C CE2 . PHE A 1 90  ? -12.45773 13.42180 -5.85256  1.000 21.13703  ? 90  PHE A CE2 1 
ATOM   669  C CZ  . PHE A 1 90  ? -13.11339 12.26791 -6.04409  1.000 23.91445  ? 90  PHE A CZ  1 
ATOM   670  N N   . SER A 1 91  ? -15.85937 13.87152 -0.44484  1.000 20.23603  ? 91  SER A N   1 
ATOM   671  C CA  . SER A 1 91  ? -16.74363 12.82583 0.04041   1.000 22.39175  ? 91  SER A CA  1 
ATOM   672  C C   . SER A 1 91  ? -18.13922 13.20935 -0.40709  1.000 19.01705  ? 91  SER A C   1 
ATOM   673  O O   . SER A 1 91  ? -18.55121 14.35143 -0.21588  1.000 20.76391  ? 91  SER A O   1 
ATOM   674  C CB  . SER A 1 91  ? -16.64475 12.69076 1.56554   1.000 20.54305  ? 91  SER A CB  1 
ATOM   675  O OG  . SER A 1 91  ? -15.35084 12.23327 1.84967   1.000 23.99205  ? 91  SER A OG  1 
ATOM   676  N N   . LEU A 1 92  ? -18.80826 12.29607 -1.11493  1.000 20.19713  ? 92  LEU A N   1 
ATOM   677  C CA  . LEU A 1 92  ? -20.07867 12.61858 -1.75952  1.000 19.88208  ? 92  LEU A CA  1 
ATOM   678  C C   . LEU A 1 92  ? -21.25281 11.94438 -1.03894  1.000 15.92911  ? 92  LEU A C   1 
ATOM   679  O O   . LEU A 1 92  ? -21.11836 10.80700 -0.55337  1.000 24.40973  ? 92  LEU A O   1 
ATOM   680  C CB  . LEU A 1 92  ? -20.05078 12.15900 -3.21608  1.000 19.43668  ? 92  LEU A CB  1 
ATOM   681  C CG  . LEU A 1 92  ? -18.78408 12.57603 -4.01373  1.000 22.96161  ? 92  LEU A CG  1 
ATOM   682  C CD1 . LEU A 1 92  ? -18.82593 11.93412 -5.41277  1.000 20.30399  ? 92  LEU A CD1 1 
ATOM   683  C CD2 . LEU A 1 92  ? -18.70936 14.07132 -4.05537  1.000 19.98940  ? 92  LEU A CD2 1 
ATOM   684  N N   . ASN A 1 93  ? -22.39043 12.63574 -1.02600  1.000 24.15764  ? 93  ASN A N   1 
ATOM   685  C CA  . ASN A 1 93  ? -23.66136 12.10519 -0.49121  1.000 22.56133  ? 93  ASN A CA  1 
ATOM   686  C C   . ASN A 1 93  ? -23.48780 11.61362 0.93719   1.000 22.00019  ? 93  ASN A C   1 
ATOM   687  O O   . ASN A 1 93  ? -23.76644 10.45745 1.24988   1.000 26.41615  ? 93  ASN A O   1 
ATOM   688  C CB  . ASN A 1 93  ? -24.20526 10.96515 -1.35468  1.000 19.62732  ? 93  ASN A CB  1 
ATOM   689  C CG  . ASN A 1 93  ? -24.23920 11.31826 -2.81919  1.000 26.11442  ? 93  ASN A CG  1 
ATOM   690  O OD1 . ASN A 1 93  ? -23.33388 10.91815 -3.55880  1.000 25.29251  ? 93  ASN A OD1 1 
ATOM   691  N ND2 . ASN A 1 93  ? -25.25975 12.09167 -3.24277  1.000 25.59148  ? 93  ASN A ND2 1 
ATOM   692  N N   . GLN A 1 94  ? -22.94159 12.47205 1.77978   1.000 19.79325  ? 94  GLN A N   1 
ATOM   693  C CA  . GLN A 1 94  ? -22.72648 12.14241 3.19030   1.000 28.46098  ? 94  GLN A CA  1 
ATOM   694  C C   . GLN A 1 94  ? -23.86131 12.83398 3.91048   1.000 23.72851  ? 94  GLN A C   1 
ATOM   695  O O   . GLN A 1 94  ? -23.82052 14.03929 4.11583   1.000 25.49049  ? 94  GLN A O   1 
ATOM   696  C CB  . GLN A 1 94  ? -21.37125 12.61358 3.71593   1.000 23.20003  ? 94  GLN A CB  1 
ATOM   697  C CG  . GLN A 1 94  ? -20.24140 11.99927 2.89862   1.000 28.47336  ? 94  GLN A CG  1 
ATOM   698  C CD  . GLN A 1 94  ? -20.20270 10.49846 3.03064   1.000 36.20950  ? 94  GLN A CD  1 
ATOM   699  O OE1 . GLN A 1 94  ? -20.03734 9.99452  4.14020   1.000 41.96480  ? 94  GLN A OE1 1 
ATOM   700  N NE2 . GLN A 1 94  ? -20.34097 9.75787  1.90765   1.000 30.20997  ? 94  GLN A NE2 1 
ATOM   701  N N   . TYR A 1 95  ? -24.89234 12.06266 4.27143   1.000 27.75277  ? 95  TYR A N   1 
ATOM   702  C CA  . TYR A 1 95  ? -26.06454 12.63737 4.94471   1.000 31.10502  ? 95  TYR A CA  1 
ATOM   703  C C   . TYR A 1 95  ? -26.61944 13.82061 4.17248   1.000 26.72342  ? 95  TYR A C   1 
ATOM   704  O O   . TYR A 1 95  ? -26.92638 14.87815 4.73179   1.000 29.65103  ? 95  TYR A O   1 
ATOM   705  C CB  . TYR A 1 95  ? -25.73693 13.02677 6.38471   1.000 26.47602  ? 95  TYR A CB  1 
ATOM   706  C CG  . TYR A 1 95  ? -25.33673 11.80974 7.14724   1.000 33.66899  ? 95  TYR A CG  1 
ATOM   707  C CD1 . TYR A 1 95  ? -26.29393 10.85848 7.53056   1.000 36.67059  ? 95  TYR A CD1 1 
ATOM   708  C CD2 . TYR A 1 95  ? -24.00193 11.57539 7.46486   1.000 40.17120  ? 95  TYR A CD2 1 
ATOM   709  C CE1 . TYR A 1 95  ? -25.93371 9.71754  8.23134   1.000 43.78956  ? 95  TYR A CE1 1 
ATOM   710  C CE2 . TYR A 1 95  ? -23.62296 10.42962 8.17629   1.000 45.84626  ? 95  TYR A CE2 1 
ATOM   711  C CZ  . TYR A 1 95  ? -24.59532 9.51031  8.55434   1.000 63.60723  ? 95  TYR A CZ  1 
ATOM   712  O OH  . TYR A 1 95  ? -24.22116 8.38282  9.24179   1.000 63.07269  ? 95  TYR A OH  1 
ATOM   713  N N   . GLY A 1 96  ? -26.72464 13.64023 2.84232   1.000 24.24392  ? 96  GLY A N   1 
ATOM   714  C CA  . GLY A 1 96  ? -27.35684 14.63487 2.01030   1.000 26.19269  ? 96  GLY A CA  1 
ATOM   715  C C   . GLY A 1 96  ? -26.43654 15.72771 1.49362   1.000 33.39141  ? 96  GLY A C   1 
ATOM   716  O O   . GLY A 1 96  ? -26.90082 16.61755 0.78437   1.000 25.48581  ? 96  GLY A O   1 
ATOM   717  N N   . LYS A 1 97  ? -25.14446 15.69054 1.82049   1.000 25.62477  ? 97  LYS A N   1 
ATOM   718  C CA  . LYS A 1 97  ? -24.22550 16.77506 1.49153   1.000 23.13398  ? 97  LYS A CA  1 
ATOM   719  C C   . LYS A 1 97  ? -23.00070 16.19105 0.78932   1.000 21.40890  ? 97  LYS A C   1 
ATOM   720  O O   . LYS A 1 97  ? -22.60600 15.06046 1.08168   1.000 24.29459  ? 97  LYS A O   1 
ATOM   721  C CB  . LYS A 1 97  ? -23.75171 17.49554 2.74228   1.000 28.02953  ? 97  LYS A CB  1 
ATOM   722  C CG  . LYS A 1 97  ? -24.86865 18.14756 3.53866   1.000 41.90121  ? 97  LYS A CG  1 
ATOM   723  C CD  . LYS A 1 97  ? -25.42097 19.27590 2.71806   1.000 30.54003  ? 97  LYS A CD  1 
ATOM   724  C CE  . LYS A 1 97  ? -26.13414 20.31115 3.59666   1.000 58.46991  ? 97  LYS A CE  1 
ATOM   725  N NZ  . LYS A 1 97  ? -26.49482 21.53149 2.79086   1.000 67.06678  ? 97  LYS A NZ  1 
ATOM   726  N N   . ASP A 1 98  ? -22.39874 16.97576 -0.10548  1.000 23.51194  ? 98  ASP A N   1 
ATOM   727  C CA  . ASP A 1 98  ? -21.03998 16.71843 -0.59007  1.000 20.14122  ? 98  ASP A CA  1 
ATOM   728  C C   . ASP A 1 98  ? -20.04875 17.62982 0.15885   1.000 17.13524  ? 98  ASP A C   1 
ATOM   729  O O   . ASP A 1 98  ? -20.35163 18.78444 0.46559   1.000 22.64632  ? 98  ASP A O   1 
ATOM   730  C CB  . ASP A 1 98  ? -20.88449 17.02875 -2.09069  1.000 19.91961  ? 98  ASP A CB  1 
ATOM   731  C CG  . ASP A 1 98  ? -21.68538 16.08573 -3.02464  1.000 25.79530  ? 98  ASP A CG  1 
ATOM   732  O OD1 . ASP A 1 98  ? -22.30758 15.10123 -2.55788  1.000 24.61311  ? 98  ASP A OD1 1 
ATOM   733  O OD2 . ASP A 1 98  ? -21.65496 16.36122 -4.26313  1.000 22.48431  ? 98  ASP A OD2 1 
ATOM   734  N N   . TYR A 1 99  ? -18.82636 17.13060 0.36777   1.000 21.06080  ? 99  TYR A N   1 
ATOM   735  C CA  . TYR A 1 99  ? -17.77946 17.94065 0.99804   1.000 22.55226  ? 99  TYR A CA  1 
ATOM   736  C C   . TYR A 1 99  ? -16.54400 17.92732 0.10569   1.000 20.99513  ? 99  TYR A C   1 
ATOM   737  O O   . TYR A 1 99  ? -16.07345 16.84989 -0.25174  1.000 21.68584  ? 99  TYR A O   1 
ATOM   738  C CB  . TYR A 1 99  ? -17.39229 17.39269 2.36988   1.000 23.38116  ? 99  TYR A CB  1 
ATOM   739  C CG  . TYR A 1 99  ? -18.53990 17.46837 3.34640   1.000 22.17125  ? 99  TYR A CG  1 
ATOM   740  C CD1 . TYR A 1 99  ? -18.79808 18.62317 4.02498   1.000 24.32783  ? 99  TYR A CD1 1 
ATOM   741  C CD2 . TYR A 1 99  ? -19.40743 16.39305 3.50355   1.000 29.28796  ? 99  TYR A CD2 1 
ATOM   742  C CE1 . TYR A 1 99  ? -19.88332 18.71959 4.89410   1.000 37.05523  ? 99  TYR A CE1 1 
ATOM   743  C CE2 . TYR A 1 99  ? -20.47436 16.47121 4.37287   1.000 32.72828  ? 99  TYR A CE2 1 
ATOM   744  C CZ  . TYR A 1 99  ? -20.69277 17.63415 5.07143   1.000 34.21623  ? 99  TYR A CZ  1 
ATOM   745  O OH  . TYR A 1 99  ? -21.76129 17.71883 5.93734   1.000 35.07637  ? 99  TYR A OH  1 
ATOM   746  N N   . ILE A 1 100 ? -16.02889 19.09706 -0.23210  1.000 19.29996  ? 100 ILE A N   1 
ATOM   747  C CA  . ILE A 1 100 ? -14.84642 19.16510 -1.09716  1.000 19.19521  ? 100 ILE A CA  1 
ATOM   748  C C   . ILE A 1 100 ? -13.78219 20.05747 -0.46576  1.000 20.79580  ? 100 ILE A C   1 
ATOM   749  O O   . ILE A 1 100 ? -14.08134 20.99916 0.27585   1.000 20.76093  ? 100 ILE A O   1 
ATOM   750  C CB  . ILE A 1 100 ? -15.20046 19.68767 -2.51169  1.000 19.81893  ? 100 ILE A CB  1 
ATOM   751  C CG1 . ILE A 1 100 ? -15.55561 21.18131 -2.47645  1.000 21.97701  ? 100 ILE A CG1 1 
ATOM   752  C CG2 . ILE A 1 100 ? -16.32732 18.83328 -3.12530  1.000 18.83807  ? 100 ILE A CG2 1 
ATOM   753  C CD1 . ILE A 1 100 ? -15.69060 21.75353 -3.90593  1.000 23.49535  ? 100 ILE A CD1 1 
ATOM   754  N N   . ASP A 1 101 ? -12.52613 19.78240 -0.80224  1.000 19.18488  ? 101 ASP A N   1 
ATOM   755  C CA  . ASP A 1 101 ? -11.46364 20.65596 -0.32553  1.000 19.04574  ? 101 ASP A CA  1 
ATOM   756  C C   . ASP A 1 101 ? -10.26655 20.43114 -1.22152  1.000 18.22913  ? 101 ASP A C   1 
ATOM   757  O O   . ASP A 1 101 ? -10.22109 19.48108 -2.00616  1.000 18.07597  ? 101 ASP A O   1 
ATOM   758  C CB  . ASP A 1 101 ? -11.11240 20.38936 1.15302   1.000 19.34870  ? 101 ASP A CB  1 
ATOM   759  C CG  . ASP A 1 101 ? -10.46303 19.03921 1.35131   1.000 24.04312  ? 101 ASP A CG  1 
ATOM   760  O OD1 . ASP A 1 101 ? -9.25471  18.87403 1.05239   1.000 20.02205  ? 101 ASP A OD1 1 
ATOM   761  O OD2 . ASP A 1 101 ? -11.16214 18.09358 1.76210   1.000 21.25732  ? 101 ASP A OD2 1 
ATOM   762  N N   . ILE A 1 102 ? -9.32923  21.35458 -1.12564  1.000 17.95288  ? 102 ILE A N   1 
ATOM   763  C CA  . ILE A 1 102 ? -7.98201  21.16917 -1.67220  1.000 14.41971  ? 102 ILE A CA  1 
ATOM   764  C C   . ILE A 1 102 ? -7.02951  21.09045 -0.50017  1.000 18.05107  ? 102 ILE A C   1 
ATOM   765  O O   . ILE A 1 102 ? -7.23446  21.76776 0.51901   1.000 18.64428  ? 102 ILE A O   1 
ATOM   766  C CB  . ILE A 1 102 ? -7.61065  22.32163 -2.60740  1.000 14.66578  ? 102 ILE A CB  1 
ATOM   767  C CG1 . ILE A 1 102 ? -8.43050  22.20607 -3.91970  1.000 17.43663  ? 102 ILE A CG1 1 
ATOM   768  C CG2 . ILE A 1 102 ? -6.12779  22.26199 -2.93054  1.000 22.19596  ? 102 ILE A CG2 1 
ATOM   769  C CD1 . ILE A 1 102 ? -8.11634  23.37299 -4.80487  1.000 21.17465  ? 102 ILE A CD1 1 
ATOM   770  N N   . SER A 1 103 ? -6.04408  20.19296 -0.60404  1.000 15.82402  ? 103 SER A N   1 
ATOM   771  C CA  . SER A 1 103 ? -5.13066  19.96692 0.49512   1.000 17.33944  ? 103 SER A CA  1 
ATOM   772  C C   . SER A 1 103 ? -3.69985  20.05451 -0.01142  1.000 16.56367  ? 103 SER A C   1 
ATOM   773  O O   . SER A 1 103 ? -3.40089  19.52122 -1.08227  1.000 17.80654  ? 103 SER A O   1 
ATOM   774  C CB  . SER A 1 103 ? -5.38600  18.60431 1.09081   1.000 19.54614  ? 103 SER A CB  1 
ATOM   775  O OG  . SER A 1 103 ? -4.35597  18.29531 2.01725   1.000 17.38911  ? 103 SER A OG  1 
ATOM   776  N N   . ASN A 1 104 ? -2.82529  20.72553 0.76056   1.000 15.99386  ? 104 ASN A N   1 
ATOM   777  C CA  . ASN A 1 104 ? -1.36547  20.70955 0.63555   1.000 15.55246  ? 104 ASN A CA  1 
ATOM   778  C C   . ASN A 1 104 ? -0.70211  19.84338 1.71746   1.000 16.34431  ? 104 ASN A C   1 
ATOM   779  O O   . ASN A 1 104 ? 0.50567   19.95902 1.93453   1.000 18.80913  ? 104 ASN A O   1 
ATOM   780  C CB  . ASN A 1 104 ? -0.78586  22.13425 0.71638   1.000 14.63470  ? 104 ASN A CB  1 
ATOM   781  C CG  . ASN A 1 104 ? -1.11280  22.95364 -0.55444  1.000 20.13607  ? 104 ASN A CG  1 
ATOM   782  O OD1 . ASN A 1 104 ? -1.01978  22.42445 -1.64600  1.000 19.35491  ? 104 ASN A OD1 1 
ATOM   783  N ND2 . ASN A 1 104 ? -1.50015  24.19884 -0.39808  1.000 20.21147  ? 104 ASN A ND2 1 
ATOM   784  N N   . ILE A 1 105 ? -1.47527  18.97942 2.37626   1.000 15.32282  ? 105 ILE A N   1 
ATOM   785  C CA  . ILE A 1 105 ? -0.92776  18.16446 3.46164   1.000 18.12296  ? 105 ILE A CA  1 
ATOM   786  C C   . ILE A 1 105 ? 0.08209   17.18213 2.93478   1.000 19.54632  ? 105 ILE A C   1 
ATOM   787  O O   . ILE A 1 105 ? 0.99798   16.78917 3.66755   1.000 15.27806  ? 105 ILE A O   1 
ATOM   788  C CB  . ILE A 1 105 ? -2.06238  17.45197 4.22956   1.000 20.46945  ? 105 ILE A CB  1 
ATOM   789  C CG1 . ILE A 1 105 ? -2.79573  18.50187 5.05323   1.000 20.96708  ? 105 ILE A CG1 1 
ATOM   790  C CG2 . ILE A 1 105 ? -1.54268  16.30189 5.10358   1.000 19.71708  ? 105 ILE A CG2 1 
ATOM   791  C CD1 . ILE A 1 105 ? -4.18059  17.97713 5.57183   1.000 22.67094  ? 105 ILE A CD1 1 
ATOM   792  N N   . LYS A 1 106 ? -0.03513  16.79143 1.66519   1.000 14.68761  ? 106 LYS A N   1 
ATOM   793  C CA  . LYS A 1 106 ? 0.91981   15.90477 1.02686   1.000 15.43319  ? 106 LYS A CA  1 
ATOM   794  C C   . LYS A 1 106 ? 1.75856   16.68037 0.01678   1.000 17.71865  ? 106 LYS A C   1 
ATOM   795  O O   . LYS A 1 106 ? 2.23570   16.10627 -0.94888  1.000 17.33094  ? 106 LYS A O   1 
ATOM   796  C CB  . LYS A 1 106 ? 0.21072   14.72784 0.32750   1.000 17.46523  ? 106 LYS A CB  1 
ATOM   797  C CG  . LYS A 1 106 ? -0.61770  13.82005 1.30258   1.000 20.82987  ? 106 LYS A CG  1 
ATOM   798  C CD  . LYS A 1 106 ? 0.36786   13.11911 2.16277   1.000 32.77156  ? 106 LYS A CD  1 
ATOM   799  C CE  . LYS A 1 106 ? -0.28124  12.11668 3.09402   1.000 41.20470  ? 106 LYS A CE  1 
ATOM   800  N NZ  . LYS A 1 106 ? 0.83153   11.66875 3.98060   1.000 38.21125  ? 106 LYS A NZ  1 
ATOM   801  N N   . GLY A 1 107 ? 1.91870   17.97283 0.22721   1.000 12.83559  ? 107 GLY A N   1 
ATOM   802  C CA  . GLY A 1 107 ? 2.80356   18.77469 -0.61154  1.000 14.19276  ? 107 GLY A CA  1 
ATOM   803  C C   . GLY A 1 107 ? 2.04938   19.31473 -1.81681  1.000 17.99866  ? 107 GLY A C   1 
ATOM   804  O O   . GLY A 1 107 ? 0.82861   19.20049 -1.91713  1.000 19.78051  ? 107 GLY A O   1 
ATOM   805  N N   . PHE A 1 108 ? 2.80703   19.90804 -2.73654  1.000 14.38259  ? 108 PHE A N   1 
ATOM   806  C CA  . PHE A 1 108 ? 2.21466   20.63000 -3.87081  1.000 18.76515  ? 108 PHE A CA  1 
ATOM   807  C C   . PHE A 1 108 ? 3.03216   20.29235 -5.10944  1.000 17.39186  ? 108 PHE A C   1 
ATOM   808  O O   . PHE A 1 108 ? 4.26032   20.29922 -5.08456  1.000 18.81184  ? 108 PHE A O   1 
ATOM   809  C CB  . PHE A 1 108 ? 2.17069   22.16018 -3.56254  1.000 16.31756  ? 108 PHE A CB  1 
ATOM   810  C CG  . PHE A 1 108 ? 1.73430   23.05382 -4.75113  1.000 13.40055  ? 108 PHE A CG  1 
ATOM   811  C CD1 . PHE A 1 108 ? 2.61799   23.32156 -5.82191  1.000 14.66069  ? 108 PHE A CD1 1 
ATOM   812  C CD2 . PHE A 1 108 ? 0.45960   23.59120 -4.77769  1.000 18.49184  ? 108 PHE A CD2 1 
ATOM   813  C CE1 . PHE A 1 108 ? 2.23476   24.10880 -6.90788  1.000 19.54645  ? 108 PHE A CE1 1 
ATOM   814  C CE2 . PHE A 1 108 ? 0.05607   24.43454 -5.84430  1.000 18.90569  ? 108 PHE A CE2 1 
ATOM   815  C CZ  . PHE A 1 108 ? 0.93275   24.68232 -6.92286  1.000 17.66216  ? 108 PHE A CZ  1 
ATOM   816  N N   . ASN A 1 109 ? 2.33455   19.95661 -6.21392  1.000 14.84156  ? 109 ASN A N   1 
ATOM   817  C CA  . ASN A 1 109 ? 3.10011   19.83505 -7.43624  1.000 12.09097  ? 109 ASN A CA  1 
ATOM   818  C C   . ASN A 1 109 ? 2.53176   20.66372 -8.57429  1.000 18.13525  ? 109 ASN A C   1 
ATOM   819  O O   . ASN A 1 109 ? 3.30414   21.26606 -9.32048  1.000 19.02498  ? 109 ASN A O   1 
ATOM   820  C CB  . ASN A 1 109 ? 3.22406   18.33844 -7.83404  1.000 15.78766  ? 109 ASN A CB  1 
ATOM   821  C CG  . ASN A 1 109 ? 1.86978   17.65927 -8.11984  1.000 14.43784  ? 109 ASN A CG  1 
ATOM   822  O OD1 . ASN A 1 109 ? 0.81047   18.09550 -7.67736  1.000 16.35977  ? 109 ASN A OD1 1 
ATOM   823  N ND2 . ASN A 1 109 ? 1.92823   16.60716 -8.93162  1.000 15.58160  ? 109 ASN A ND2 1 
ATOM   824  N N   . VAL A 1 110 ? 1.21433   20.75203 -8.69685  1.000 15.79830  ? 110 VAL A N   1 
ATOM   825  C CA  . VAL A 1 110 ? 0.60034   21.46203 -9.83204  1.000 17.11593  ? 110 VAL A CA  1 
ATOM   826  C C   . VAL A 1 110 ? -0.48689  22.36420 -9.26114  1.000 15.52664  ? 110 VAL A C   1 
ATOM   827  O O   . VAL A 1 110 ? -1.21284  21.89234 -8.35172  1.000 19.35966  ? 110 VAL A O   1 
ATOM   828  C CB  . VAL A 1 110 ? -0.01041  20.42823 -10.82122 1.000 20.61988  ? 110 VAL A CB  1 
ATOM   829  C CG1 . VAL A 1 110 ? -0.87531  21.11915 -11.85569 1.000 22.98345  ? 110 VAL A CG1 1 
ATOM   830  C CG2 . VAL A 1 110 ? 1.10614   19.54409 -11.48859 1.000 18.93110  ? 110 VAL A CG2 1 
ATOM   831  N N   . PRO A 1 111 ? -0.65493  23.61337 -9.72006  1.000 16.40304  ? 111 PRO A N   1 
ATOM   832  C CA  . PRO A 1 111 ? -1.73914  24.46077 -9.21142  1.000 16.77558  ? 111 PRO A CA  1 
ATOM   833  C C   . PRO A 1 111 ? -3.07095  23.90792 -9.67657  1.000 18.21121  ? 111 PRO A C   1 
ATOM   834  O O   . PRO A 1 111 ? -3.15237  23.24164 -10.71587 1.000 17.13205  ? 111 PRO A O   1 
ATOM   835  C CB  . PRO A 1 111 ? -1.46042  25.85008 -9.83198  1.000 17.59342  ? 111 PRO A CB  1 
ATOM   836  C CG  . PRO A 1 111 ? -0.51304  25.62275 -10.90901 1.000 24.72834  ? 111 PRO A CG  1 
ATOM   837  C CD  . PRO A 1 111 ? 0.18898   24.33143 -10.72160 1.000 18.25114  ? 111 PRO A CD  1 
ATOM   838  N N   . MET A 1 112 ? -4.10184  24.18455 -8.90120  1.000 16.83029  ? 112 MET A N   1 
ATOM   839  C CA  . MET A 1 112 ? -5.38445  23.50004 -9.09461  1.000 17.29184  ? 112 MET A CA  1 
ATOM   840  C C   . MET A 1 112 ? -6.54160  24.38519 -8.66979  1.000 18.82008  ? 112 MET A C   1 
ATOM   841  O O   . MET A 1 112 ? -6.43390  25.12590 -7.69079  1.000 18.71005  ? 112 MET A O   1 
ATOM   842  C CB  . MET A 1 112 ? -5.37279  22.18891 -8.26919  1.000 22.76037  ? 112 MET A CB  1 
ATOM   843  C CG  . MET A 1 112 ? -6.67631  21.49914 -8.11121  1.000 31.81763  ? 112 MET A CG  1 
ATOM   844  S SD  . MET A 1 112 ? -6.45439  20.20316 -6.86890  1.000 27.63849  ? 112 MET A SD  1 
ATOM   845  C CE  . MET A 1 112 ? -5.43388  19.07148 -7.74070  1.000 23.39416  ? 112 MET A CE  1 
ATOM   846  N N   . ASP A 1 113 ? -7.64501  24.31366 -9.43100  1.000 17.04539  ? 113 ASP A N   1 
ATOM   847  C CA  . ASP A 1 113 ? -8.94231  24.86923 -9.06080  1.000 16.91573  ? 113 ASP A CA  1 
ATOM   848  C C   . ASP A 1 113 ? -9.90247  23.68700 -8.96636  1.000 19.03900  ? 113 ASP A C   1 
ATOM   849  O O   . ASP A 1 113 ? -9.86549  22.78817 -9.83021  1.000 18.68432  ? 113 ASP A O   1 
ATOM   850  C CB  . ASP A 1 113 ? -9.43170  25.88122 -10.13378 1.000 17.38712  ? 113 ASP A CB  1 
ATOM   851  C CG  . ASP A 1 113 ? -10.79927 26.47226 -9.80210  1.000 23.46942  ? 113 ASP A CG  1 
ATOM   852  O OD1 . ASP A 1 113 ? -11.81985 25.82345 -10.05698 1.000 22.19648  ? 113 ASP A OD1 1 
ATOM   853  O OD2 . ASP A 1 113 ? -10.82599 27.55871 -9.23345  1.000 23.76377  ? 113 ASP A OD2 1 
ATOM   854  N N   . PHE A 1 114 ? -10.74296 23.66789 -7.92452  1.000 16.31188  ? 114 PHE A N   1 
ATOM   855  C CA  . PHE A 1 114 ? -11.69363 22.57660 -7.70269  1.000 16.79593  ? 114 PHE A CA  1 
ATOM   856  C C   . PHE A 1 114 ? -13.05553 23.23157 -7.46529  1.000 19.14124  ? 114 PHE A C   1 
ATOM   857  O O   . PHE A 1 114 ? -13.25870 23.81158 -6.40538  1.000 19.63707  ? 114 PHE A O   1 
ATOM   858  C CB  . PHE A 1 114 ? -11.27456 21.74640 -6.48296  1.000 16.05072  ? 114 PHE A CB  1 
ATOM   859  C CG  . PHE A 1 114 ? -12.09372 20.52840 -6.23559  1.000 16.32011  ? 114 PHE A CG  1 
ATOM   860  C CD1 . PHE A 1 114 ? -13.08268 20.07832 -7.15497  1.000 20.85327  ? 114 PHE A CD1 1 
ATOM   861  C CD2 . PHE A 1 114 ? -11.89528 19.81252 -5.02978  1.000 16.68318  ? 114 PHE A CD2 1 
ATOM   862  C CE1 . PHE A 1 114 ? -13.81355 18.90936 -6.92082  1.000 21.11595  ? 114 PHE A CE1 1 
ATOM   863  C CE2 . PHE A 1 114 ? -12.62983 18.63628 -4.76063  1.000 19.66560  ? 114 PHE A CE2 1 
ATOM   864  C CZ  . PHE A 1 114 ? -13.60685 18.17242 -5.69763  1.000 18.76647  ? 114 PHE A CZ  1 
ATOM   865  N N   . SER A 1 115 ? -13.94621 23.21235 -8.46129  1.000 18.25669  ? 115 SER A N   1 
ATOM   866  C CA  . SER A 1 115 ? -15.16590 24.02280 -8.45055  1.000 15.88511  ? 115 SER A CA  1 
ATOM   867  C C   . SER A 1 115 ? -16.36389 23.15936 -8.84307  1.000 20.27942  ? 115 SER A C   1 
ATOM   868  O O   . SER A 1 115 ? -16.22728 22.20531 -9.62136  1.000 22.81611  ? 115 SER A O   1 
ATOM   869  C CB  . SER A 1 115 ? -15.09725 25.21376 -9.40867  1.000 21.44412  ? 115 SER A CB  1 
ATOM   870  O OG  . SER A 1 115 ? -14.15681 26.17642 -8.98932  1.000 24.52491  ? 115 SER A OG  1 
ATOM   871  N N   . PRO A 1 116 ? -17.54051 23.43879 -8.28374  1.000 22.02633  ? 116 PRO A N   1 
ATOM   872  C CA  . PRO A 1 116 ? -18.75460 22.74498 -8.74110  1.000 19.80349  ? 116 PRO A CA  1 
ATOM   873  C C   . PRO A 1 116 ? -19.15900 23.30153 -10.08850 1.000 22.29807  ? 116 PRO A C   1 
ATOM   874  O O   . PRO A 1 116 ? -18.90979 24.46852 -10.39755 1.000 24.12760  ? 116 PRO A O   1 
ATOM   875  C CB  . PRO A 1 116 ? -19.80686 23.11898 -7.68448  1.000 21.18546  ? 116 PRO A CB  1 
ATOM   876  C CG  . PRO A 1 116 ? -19.35383 24.50209 -7.21893  1.000 26.52372  ? 116 PRO A CG  1 
ATOM   877  C CD  . PRO A 1 116 ? -17.81322 24.41537 -7.20479  1.000 20.32393  ? 116 PRO A CD  1 
ATOM   878  N N   . THR A 1 117 ? -19.79111 22.45958 -10.88663 1.000 25.25974  ? 117 THR A N   1 
ATOM   879  C CA  . THR A 1 117 ? -20.40363 22.92093 -12.13966 1.000 29.19103  ? 117 THR A CA  1 
ATOM   880  C C   . THR A 1 117 ? -21.90983 23.01658 -12.03650 1.000 31.38564  ? 117 THR A C   1 
ATOM   881  O O   . THR A 1 117 ? -22.55635 23.37679 -13.02432 1.000 32.99917  ? 117 THR A O   1 
ATOM   882  C CB  . THR A 1 117 ? -20.07307 22.00204 -13.29542 1.000 26.24786  ? 117 THR A CB  1 
ATOM   883  O OG1 . THR A 1 117 ? -20.49773 20.68199 -12.98020 1.000 24.88021  ? 117 THR A OG1 1 
ATOM   884  C CG2 . THR A 1 117 ? -18.56106 22.00354 -13.61235 1.000 24.99612  ? 117 THR A CG2 1 
ATOM   885  N N   . THR A 1 118 ? -22.46931 22.67140 -10.87560 1.000 27.95190  ? 118 THR A N   1 
ATOM   886  C CA  . THR A 1 118 ? -23.88859 22.78638 -10.53397 1.000 28.30720  ? 118 THR A CA  1 
ATOM   887  C C   . THR A 1 118 ? -24.01858 23.84770 -9.44815  1.000 33.64112  ? 118 THR A C   1 
ATOM   888  O O   . THR A 1 118 ? -23.01903 24.34930 -8.93514  1.000 32.60513  ? 118 THR A O   1 
ATOM   889  C CB  . THR A 1 118 ? -24.43010 21.41967 -10.09144 1.000 30.62750  ? 118 THR A CB  1 
ATOM   890  O OG1 . THR A 1 118 ? -23.58627 20.88552 -9.05041  1.000 30.96894  ? 118 THR A OG1 1 
ATOM   891  C CG2 . THR A 1 118 ? -24.45887 20.43105 -11.27991 1.000 29.98353  ? 118 THR A CG2 1 
ATOM   892  N N   . ARG A 1 119 ? -25.24931 24.22985 -9.10492  1.000 35.38670  ? 119 ARG A N   1 
ATOM   893  C CA  . ARG A 1 119 ? -25.39874 25.39491 -8.23274  1.000 35.61672  ? 119 ARG A CA  1 
ATOM   894  C C   . ARG A 1 119 ? -25.27948 25.01696 -6.75756  1.000 39.25246  ? 119 ARG A C   1 
ATOM   895  O O   . ARG A 1 119 ? -25.43366 23.85488 -6.36893  1.000 48.58848  ? 119 ARG A O   1 
ATOM   896  C CB  . ARG A 1 119 ? -26.74160 26.11459 -8.45496  1.000 44.79797  ? 119 ARG A CB  1 
ATOM   897  N N   . GLY A 1 120 ? -25.00129 26.02719 -5.92788  1.000 30.92320  ? 120 GLY A N   1 
ATOM   898  C CA  . GLY A 1 120 ? -25.22530 25.88976 -4.50611  1.000 36.27527  ? 120 GLY A CA  1 
ATOM   899  C C   . GLY A 1 120 ? -24.00399 25.88609 -3.61421  1.000 37.09339  ? 120 GLY A C   1 
ATOM   900  O O   . GLY A 1 120 ? -24.16019 25.67549 -2.40522  1.000 34.93684  ? 120 GLY A O   1 
ATOM   901  N N   . CYS A 1 121 ? -22.80197 26.11829 -4.14682  1.000 31.76451  ? 121 CYS A N   1 
ATOM   902  C CA  . CYS A 1 121 ? -21.61784 26.26229 -3.30718  1.000 32.69839  ? 121 CYS A CA  1 
ATOM   903  C C   . CYS A 1 121 ? -20.54314 26.89933 -4.17081  1.000 35.72585  ? 121 CYS A C   1 
ATOM   904  O O   . CYS A 1 121 ? -20.70534 27.04681 -5.38100  1.000 36.18179  ? 121 CYS A O   1 
ATOM   905  C CB  . CYS A 1 121 ? -21.16807 24.91378 -2.72901  1.000 24.04568  ? 121 CYS A CB  1 
ATOM   906  S SG  . CYS A 1 121 ? -21.00334 23.67555 -4.04628  1.000 27.19393  ? 121 CYS A SG  1 
ATOM   907  N N   . ARG A 1 122 ? -19.44567 27.25441 -3.54521  1.000 29.88867  ? 122 ARG A N   1 
ATOM   908  C CA  . ARG A 1 122 ? -18.33799 27.93506 -4.20427  1.000 31.12466  ? 122 ARG A CA  1 
ATOM   909  C C   . ARG A 1 122 ? -17.19569 26.95027 -4.43968  1.000 27.34284  ? 122 ARG A C   1 
ATOM   910  O O   . ARG A 1 122 ? -17.18463 25.84160 -3.91635  1.000 28.67066  ? 122 ARG A O   1 
ATOM   911  C CB  . ARG A 1 122 ? -17.82870 29.09890 -3.34929  1.000 34.61146  ? 122 ARG A CB  1 
ATOM   912  C CG  . ARG A 1 122 ? -17.29026 28.66172 -1.97061  1.000 37.06630  ? 122 ARG A CG  1 
ATOM   913  C CD  . ARG A 1 122 ? -15.90402 29.24784 -1.74136  1.000 62.95835  ? 122 ARG A CD  1 
ATOM   914  N NE  . ARG A 1 122 ? -15.25267 28.87147 -0.48616  1.000 72.08018  ? 122 ARG A NE  1 
ATOM   915  C CZ  . ARG A 1 122 ? -13.96001 29.07298 -0.23276  1.000 79.46707  ? 122 ARG A CZ  1 
ATOM   916  N NH1 . ARG A 1 122 ? -13.14376 29.59023 -1.14612  1.000 66.83045  ? 122 ARG A NH1 1 
ATOM   917  N NH2 . ARG A 1 122 ? -13.47074 28.75102 0.96544   1.000 74.15093  ? 122 ARG A NH2 1 
ATOM   918  N N   . GLY A 1 123 ? -16.26104 27.34902 -5.27545  1.000 24.78134  ? 123 GLY A N   1 
ATOM   919  C CA  . GLY A 1 123 ? -15.10222 26.51701 -5.51514  1.000 21.61384  ? 123 GLY A CA  1 
ATOM   920  C C   . GLY A 1 123 ? -13.92555 26.93194 -4.59783  1.000 25.58582  ? 123 GLY A C   1 
ATOM   921  O O   . GLY A 1 123 ? -13.98927 27.89326 -3.83565  1.000 26.21032  ? 123 GLY A O   1 
ATOM   922  N N   . VAL A 1 124 ? -12.83374 26.17735 -4.68168  1.000 22.09017  ? 124 VAL A N   1 
ATOM   923  C CA  . VAL A 1 124 ? -11.61069 26.49767 -3.94650  1.000 24.13596  ? 124 VAL A CA  1 
ATOM   924  C C   . VAL A 1 124 ? -10.45798 26.40639 -4.92812  1.000 24.81215  ? 124 VAL A C   1 
ATOM   925  O O   . VAL A 1 124 ? -10.52969 25.71170 -5.93922  1.000 19.21888  ? 124 VAL A O   1 
ATOM   926  C CB  . VAL A 1 124 ? -11.36342 25.54624 -2.74760  1.000 26.96952  ? 124 VAL A CB  1 
ATOM   927  C CG1 . VAL A 1 124 ? -12.32160 25.90100 -1.59604  1.000 34.83504  ? 124 VAL A CG1 1 
ATOM   928  C CG2 . VAL A 1 124 ? -11.54626 24.13298 -3.16467  1.000 25.45273  ? 124 VAL A CG2 1 
ATOM   929  N N   . ARG A 1 125 ? -9.36677  27.06214 -4.59685  1.000 18.62275  ? 125 ARG A N   1 
ATOM   930  C CA  . ARG A 1 125 ? -8.27235  27.15185 -5.54382  1.000 20.42296  ? 125 ARG A CA  1 
ATOM   931  C C   . ARG A 1 125 ? -6.96490  27.28894 -4.77266  1.000 25.63597  ? 125 ARG A C   1 
ATOM   932  O O   . ARG A 1 125 ? -6.90236  27.96790 -3.74241  1.000 22.27630  ? 125 ARG A O   1 
ATOM   933  C CB  . ARG A 1 125 ? -8.50153  28.36205 -6.47177  1.000 24.76489  ? 125 ARG A CB  1 
ATOM   934  C CG  . ARG A 1 125 ? -7.34604  28.71261 -7.40080  1.000 34.83952  ? 125 ARG A CG  1 
ATOM   935  C CD  . ARG A 1 125 ? -7.71157  29.92793 -8.27764  1.000 34.10917  ? 125 ARG A CD  1 
ATOM   936  N NE  . ARG A 1 125 ? -8.87221  29.62602 -9.10868  1.000 38.46087  ? 125 ARG A NE  1 
ATOM   937  C CZ  . ARG A 1 125 ? -9.19019  30.27883 -10.22371 1.000 52.20646  ? 125 ARG A CZ  1 
ATOM   938  N NH1 . ARG A 1 125 ? -8.46903  31.30010 -10.65882 1.000 48.23496  ? 125 ARG A NH1 1 
ATOM   939  N NH2 . ARG A 1 125 ? -10.24420 29.88662 -10.92884 1.000 39.44074  ? 125 ARG A NH2 1 
ATOM   940  N N   . CYS A 1 126 ? -5.91536  26.66665 -5.27956  1.000 16.92539  ? 126 CYS A N   1 
ATOM   941  C CA  . CYS A 1 126 ? -4.54974  26.96867 -4.82039  1.000 19.15279  ? 126 CYS A CA  1 
ATOM   942  C C   . CYS A 1 126 ? -3.72237  27.13958 -6.09276  1.000 20.92643  ? 126 CYS A C   1 
ATOM   943  O O   . CYS A 1 126 ? -3.33278  26.14312 -6.71628  1.000 19.13862  ? 126 CYS A O   1 
ATOM   944  C CB  . CYS A 1 126 ? -3.99810  25.86230 -3.93431  1.000 18.64390  ? 126 CYS A CB  1 
ATOM   945  S SG  . CYS A 1 126 ? -2.25287  26.10423 -3.51563  1.000 19.82357  ? 126 CYS A SG  1 
ATOM   946  N N   . ALA A 1 127 ? -3.49905  28.39335 -6.51137  1.000 20.82877  ? 127 ALA A N   1 
ATOM   947  C CA  . ALA A 1 127 ? -2.82977  28.61163 -7.79098  1.000 27.76458  ? 127 ALA A CA  1 
ATOM   948  C C   . ALA A 1 127 ? -1.55027  29.42092 -7.66040  1.000 27.79142  ? 127 ALA A C   1 
ATOM   949  O O   . ALA A 1 127 ? -0.98852  29.84436 -8.67847  1.000 28.73409  ? 127 ALA A O   1 
ATOM   950  C CB  . ALA A 1 127 ? -3.78642  29.26666 -8.79623  1.000 19.66728  ? 127 ALA A CB  1 
ATOM   951  N N   . ALA A 1 128 ? -1.04426  29.60363 -6.45100  1.000 25.52674  ? 128 ALA A N   1 
ATOM   952  C CA  . ALA A 1 128 ? 0.20115   30.31641 -6.24918  1.000 24.80844  ? 128 ALA A CA  1 
ATOM   953  C C   . ALA A 1 128 ? 1.38692   29.50179 -6.73271  1.000 22.52920  ? 128 ALA A C   1 
ATOM   954  O O   . ALA A 1 128 ? 1.31730   28.28125 -6.92972  1.000 22.91902  ? 128 ALA A O   1 
ATOM   955  C CB  . ALA A 1 128 ? 0.37912   30.64315 -4.76879  1.000 20.59362  ? 128 ALA A CB  1 
ATOM   956  N N   . ASP A 1 129 ? 2.51837   30.19107 -6.90027  1.000 22.09029  ? 129 ASP A N   1 
ATOM   957  C CA  . ASP A 1 129 ? 3.74389   29.54773 -7.35937  1.000 27.89165  ? 129 ASP A CA  1 
ATOM   958  C C   . ASP A 1 129 ? 4.48781   28.95290 -6.15610  1.000 23.54794  ? 129 ASP A C   1 
ATOM   959  O O   . ASP A 1 129 ? 5.56686   29.39368 -5.76480  1.000 20.43040  ? 129 ASP A O   1 
ATOM   960  C CB  . ASP A 1 129 ? 4.63086   30.54442 -8.09514  1.000 28.55865  ? 129 ASP A CB  1 
ATOM   961  C CG  . ASP A 1 129 ? 5.87138   29.89243 -8.66354  1.000 24.30126  ? 129 ASP A CG  1 
ATOM   962  O OD1 . ASP A 1 129 ? 5.93100   28.63844 -8.77564  1.000 29.77872  ? 129 ASP A OD1 1 
ATOM   963  O OD2 . ASP A 1 129 ? 6.80073   30.64020 -8.96194  1.000 34.70262  ? 129 ASP A OD2 1 
ATOM   964  N N   . ILE A 1 130 ? 3.88553   27.91703 -5.57878  1.000 18.44585  ? 130 ILE A N   1 
ATOM   965  C CA  . ILE A 1 130 ? 4.49412   27.26704 -4.42853  1.000 16.07526  ? 130 ILE A CA  1 
ATOM   966  C C   . ILE A 1 130 ? 5.79689   26.57528 -4.79099  1.000 17.54977  ? 130 ILE A C   1 
ATOM   967  O O   . ILE A 1 130 ? 6.72426   26.52921 -3.98118  1.000 21.62071  ? 130 ILE A O   1 
ATOM   968  C CB  . ILE A 1 130 ? 3.44664   26.32930 -3.81411  1.000 15.12596  ? 130 ILE A CB  1 
ATOM   969  C CG1 . ILE A 1 130 ? 2.41268   27.18269 -3.07413  1.000 19.47475  ? 130 ILE A CG1 1 
ATOM   970  C CG2 . ILE A 1 130 ? 4.14052   25.25971 -2.89342  1.000 19.47414  ? 130 ILE A CG2 1 
ATOM   971  C CD1 . ILE A 1 130 ? 1.37369   26.39081 -2.32623  1.000 22.88792  ? 130 ILE A CD1 1 
ATOM   972  N N   . VAL A 1 131 ? 5.91158   25.99631 -5.99438  1.000 18.82131  ? 131 VAL A N   1 
ATOM   973  C CA  . VAL A 1 131 ? 7.16236   25.34751 -6.33386  1.000 20.38359  ? 131 VAL A CA  1 
ATOM   974  C C   . VAL A 1 131 ? 8.29258   26.36983 -6.41934  1.000 24.57202  ? 131 VAL A C   1 
ATOM   975  O O   . VAL A 1 131 ? 9.39138   26.13598 -5.88904  1.000 20.10469  ? 131 VAL A O   1 
ATOM   976  C CB  . VAL A 1 131 ? 7.04167   24.52471 -7.63839  1.000 21.17419  ? 131 VAL A CB  1 
ATOM   977  C CG1 . VAL A 1 131 ? 8.38435   23.90533 -7.96808  1.000 25.53906  ? 131 VAL A CG1 1 
ATOM   978  C CG2 . VAL A 1 131 ? 6.02476   23.38479 -7.42893  1.000 23.57877  ? 131 VAL A CG2 1 
ATOM   979  N N   . GLY A 1 132 ? 8.04953   27.50682 -7.07403  1.000 19.97963  ? 132 GLY A N   1 
ATOM   980  C CA  . GLY A 1 132 ? 9.11961   28.48873 -7.20407  1.000 20.96899  ? 132 GLY A CA  1 
ATOM   981  C C   . GLY A 1 132 ? 9.54950   29.06844 -5.86411  1.000 27.35514  ? 132 GLY A C   1 
ATOM   982  O O   . GLY A 1 132 ? 10.73603  29.36529 -5.65429  1.000 26.70682  ? 132 GLY A O   1 
ATOM   983  N N   . GLN A 1 133 ? 8.59869   29.23707 -4.94049  1.000 18.25174  ? 133 GLN A N   1 
ATOM   984  C CA  . GLN A 1 133 ? 8.87819   29.86098 -3.64179  1.000 19.03925  ? 133 GLN A CA  1 
ATOM   985  C C   . GLN A 1 133 ? 9.26614   28.82627 -2.56270  1.000 19.34289  ? 133 GLN A C   1 
ATOM   986  O O   . GLN A 1 133 ? 9.55018   29.20263 -1.41771  1.000 19.59581  ? 133 GLN A O   1 
ATOM   987  C CB  . GLN A 1 133 ? 7.65054   30.66510 -3.16642  1.000 20.29070  ? 133 GLN A CB  1 
ATOM   988  C CG  . GLN A 1 133 ? 7.18642   31.88079 -4.04448  1.000 25.43655  ? 133 GLN A CG  1 
ATOM   989  C CD  . GLN A 1 133 ? 8.27693   32.90088 -4.31461  1.000 38.01594  ? 133 GLN A CD  1 
ATOM   990  O OE1 . GLN A 1 133 ? 9.34031   32.89257 -3.69882  1.000 29.91042  ? 133 GLN A OE1 1 
ATOM   991  N NE2 . GLN A 1 133 ? 8.03373   33.76293 -5.28032  1.000 43.93903  ? 133 GLN A NE2 1 
ATOM   992  N N   . CYS A 1 134 ? 9.23810   27.54155 -2.89300  1.000 19.37284  ? 134 CYS A N   1 
ATOM   993  C CA  . CYS A 1 134 ? 9.36042   26.44096 -1.92216  1.000 16.86265  ? 134 CYS A CA  1 
ATOM   994  C C   . CYS A 1 134 ? 10.63661  26.59158 -1.07992  1.000 24.73118  ? 134 CYS A C   1 
ATOM   995  O O   . CYS A 1 134 ? 11.72163  26.83772 -1.62609  1.000 22.02521  ? 134 CYS A O   1 
ATOM   996  C CB  . CYS A 1 134 ? 9.40004   25.10473 -2.67714  1.000 19.19390  ? 134 CYS A CB  1 
ATOM   997  S SG  . CYS A 1 134 ? 9.36264   23.61273 -1.63242  1.000 18.31270  ? 134 CYS A SG  1 
ATOM   998  N N   . PRO A 1 135 ? 10.55037  26.46955 0.22201   1.000 21.90062  ? 135 PRO A N   1 
ATOM   999  C CA  . PRO A 1 135 ? 11.76531  26.53169 1.04132   1.000 23.38077  ? 135 PRO A CA  1 
ATOM   1000 C C   . PRO A 1 135 ? 12.73078  25.44153 0.64374   1.000 22.48627  ? 135 PRO A C   1 
ATOM   1001 O O   . PRO A 1 135 ? 12.33678  24.32586 0.28489   1.000 19.40347  ? 135 PRO A O   1 
ATOM   1002 C CB  . PRO A 1 135 ? 11.25331  26.31173 2.46548   1.000 24.47597  ? 135 PRO A CB  1 
ATOM   1003 C CG  . PRO A 1 135 ? 9.78760   26.60508 2.41733   1.000 28.37072  ? 135 PRO A CG  1 
ATOM   1004 C CD  . PRO A 1 135 ? 9.31757   26.34745 1.03359   1.000 18.86092  ? 135 PRO A CD  1 
ATOM   1005 N N   . ALA A 1 136 ? 14.02915  25.76285 0.76857   1.000 27.13579  ? 136 ALA A N   1 
ATOM   1006 C CA  . ALA A 1 136 ? 15.08488  24.88031 0.28322   1.000 27.52049  ? 136 ALA A CA  1 
ATOM   1007 C C   . ALA A 1 136 ? 14.94565  23.44259 0.80693   1.000 19.87947  ? 136 ALA A C   1 
ATOM   1008 O O   . ALA A 1 136 ? 15.11905  22.46548 0.06119   1.000 21.27092  ? 136 ALA A O   1 
ATOM   1009 C CB  . ALA A 1 136 ? 16.44094  25.47676 0.69022   1.000 31.14074  ? 136 ALA A CB  1 
ATOM   1010 N N   . LYS A 1 137 ? 14.62557  23.27471 2.09543   1.000 18.11722  ? 137 LYS A N   1 
ATOM   1011 C CA  . LYS A 1 137 ? 14.60281  21.91204 2.61014   1.000 19.56594  ? 137 LYS A CA  1 
ATOM   1012 C C   . LYS A 1 137 ? 13.39407  21.10987 2.15720   1.000 20.42052  ? 137 LYS A C   1 
ATOM   1013 O O   . LYS A 1 137 ? 13.42032  19.88122 2.28238   1.000 25.95580  ? 137 LYS A O   1 
ATOM   1014 C CB  . LYS A 1 137 ? 14.64834  21.92202 4.14180   1.000 25.08106  ? 137 LYS A CB  1 
ATOM   1015 C CG  . LYS A 1 137 ? 15.95229  22.57220 4.67081   1.000 29.32246  ? 137 LYS A CG  1 
ATOM   1016 C CD  . LYS A 1 137 ? 16.09910  22.28151 6.15449   1.000 39.47127  ? 137 LYS A CD  1 
ATOM   1017 C CE  . LYS A 1 137 ? 17.31211  22.97534 6.74801   1.000 47.97564  ? 137 LYS A CE  1 
ATOM   1018 N NZ  . LYS A 1 137 ? 18.08184  22.00164 7.56180   1.000 67.74621  ? 137 LYS A NZ  1 
ATOM   1019 N N   . LEU A 1 138 ? 12.35388  21.76159 1.61830   1.000 18.59609  ? 138 LEU A N   1 
ATOM   1020 C CA  . LEU A 1 138 ? 11.16047  21.04905 1.15551   1.000 20.50254  ? 138 LEU A CA  1 
ATOM   1021 C C   . LEU A 1 138 ? 11.17432  20.77236 -0.34549  1.000 20.98981  ? 138 LEU A C   1 
ATOM   1022 O O   . LEU A 1 138 ? 10.28030  20.06325 -0.83537  1.000 20.79375  ? 138 LEU A O   1 
ATOM   1023 C CB  . LEU A 1 138 ? 9.90671   21.86081 1.49038   1.000 16.41505  ? 138 LEU A CB  1 
ATOM   1024 C CG  . LEU A 1 138 ? 9.67615   22.02301 2.97984   1.000 19.03596  ? 138 LEU A CG  1 
ATOM   1025 C CD1 . LEU A 1 138 ? 8.35790   22.74565 3.18019   1.000 22.32594  ? 138 LEU A CD1 1 
ATOM   1026 C CD2 . LEU A 1 138 ? 9.71451   20.65759 3.74763   1.000 17.89648  ? 138 LEU A CD2 1 
ATOM   1027 N N   . LYS A 1 139 ? 12.12707  21.33700 -1.08230  1.000 17.25483  ? 139 LYS A N   1 
ATOM   1028 C CA  . LYS A 1 139 ? 12.13064  21.15747 -2.53477  1.000 20.07732  ? 139 LYS A CA  1 
ATOM   1029 C C   . LYS A 1 139 ? 12.36330  19.70568 -2.89744  1.000 23.38189  ? 139 LYS A C   1 
ATOM   1030 O O   . LYS A 1 139 ? 13.25859  19.05961 -2.36753  1.000 27.05649  ? 139 LYS A O   1 
ATOM   1031 C CB  . LYS A 1 139 ? 13.19807  22.02905 -3.18066  1.000 26.90242  ? 139 LYS A CB  1 
ATOM   1032 C CG  . LYS A 1 139 ? 12.91685  23.49012 -3.04048  1.000 29.32973  ? 139 LYS A CG  1 
ATOM   1033 C CD  . LYS A 1 139 ? 14.10528  24.37761 -3.52912  1.000 42.96392  ? 139 LYS A CD  1 
ATOM   1034 C CE  . LYS A 1 139 ? 14.01843  24.70834 -5.02082  1.000 58.77578  ? 139 LYS A CE  1 
ATOM   1035 N NZ  . LYS A 1 139 ? 12.86738  25.63272 -5.28301  1.000 64.39538  ? 139 LYS A NZ  1 
ATOM   1036 N N   . ALA A 1 140 ? 11.56359  19.20705 -3.76368  1.000 20.99622  ? 140 ALA A N   1 
ATOM   1037 C CA  . ALA A 1 140 ? 11.73360  17.83462 -4.22439  1.000 23.40304  ? 140 ALA A CA  1 
ATOM   1038 C C   . ALA A 1 140 ? 12.52730  17.83844 -5.52796  1.000 27.54902  ? 140 ALA A C   1 
ATOM   1039 O O   . ALA A 1 140 ? 12.19085  18.59436 -6.44475  1.000 25.23401  ? 140 ALA A O   1 
ATOM   1040 C CB  . ALA A 1 140 ? 10.37938  17.17547 -4.47150  1.000 27.44391  ? 140 ALA A CB  1 
ATOM   1041 N N   . PRO A 1 141 ? 13.55939  17.00597 -5.64521  1.000 31.92623  ? 141 PRO A N   1 
ATOM   1042 C CA  . PRO A 1 141 ? 14.38087  17.01721 -6.87817  1.000 36.28094  ? 141 PRO A CA  1 
ATOM   1043 C C   . PRO A 1 141 ? 13.56199  16.73671 -8.12484  1.000 40.34304  ? 141 PRO A C   1 
ATOM   1044 O O   . PRO A 1 141 ? 13.71738  17.43292 -9.14120  1.000 42.94629  ? 141 PRO A O   1 
ATOM   1045 C CB  . PRO A 1 141 ? 15.42099  15.93087 -6.60636  1.000 36.26568  ? 141 PRO A CB  1 
ATOM   1046 C CG  . PRO A 1 141 ? 15.49591  15.83769 -5.03975  1.000 32.00830  ? 141 PRO A CG  1 
ATOM   1047 C CD  . PRO A 1 141 ? 14.05174  16.06907 -4.61438  1.000 31.85356  ? 141 PRO A CD  1 
ATOM   1048 N N   . GLY A 1 142 ? 12.61663  15.79596 -8.03754  1.000 36.01502  ? 142 GLY A N   1 
ATOM   1049 C CA  . GLY A 1 142 ? 11.72794  15.48626 -9.13924  1.000 39.33535  ? 142 GLY A CA  1 
ATOM   1050 C C   . GLY A 1 142 ? 10.81678  16.62152 -9.56851  1.000 41.81536  ? 142 GLY A C   1 
ATOM   1051 O O   . GLY A 1 142 ? 10.15769  16.53705 -10.60460 1.000 45.50975  ? 142 GLY A O   1 
ATOM   1052 N N   . GLY A 1 143 ? 10.78422  17.69700 -8.81262  1.000 36.92000  ? 143 GLY A N   1 
ATOM   1053 C CA  . GLY A 1 143 ? 9.80933   18.75294 -9.02688  1.000 31.89485  ? 143 GLY A CA  1 
ATOM   1054 C C   . GLY A 1 143 ? 8.79922   18.76566 -7.87547  1.000 28.02212  ? 143 GLY A C   1 
ATOM   1055 O O   . GLY A 1 143 ? 8.58055   17.75647 -7.18364  1.000 31.47607  ? 143 GLY A O   1 
ATOM   1056 N N   . GLY A 1 144 ? 8.22408   19.91318 -7.62352  1.000 23.69237  ? 144 GLY A N   1 
ATOM   1057 C CA  . GLY A 1 144 ? 7.26512   19.96510 -6.54162  1.000 17.97668  ? 144 GLY A CA  1 
ATOM   1058 C C   . GLY A 1 144 ? 7.89389   20.40050 -5.22733  1.000 23.10411  ? 144 GLY A C   1 
ATOM   1059 O O   . GLY A 1 144 ? 9.11164   20.57713 -5.08731  1.000 19.86825  ? 144 GLY A O   1 
ATOM   1060 N N   . CYS A 1 145 ? 7.01906   20.59897 -4.26310  1.000 15.95746  ? 145 CYS A N   1 
ATOM   1061 C CA  . CYS A 1 145 ? 7.39521   21.13726 -2.94587  1.000 16.11067  ? 145 CYS A CA  1 
ATOM   1062 C C   . CYS A 1 145 ? 6.77926   20.18492 -1.92587  1.000 18.39728  ? 145 CYS A C   1 
ATOM   1063 O O   . CYS A 1 145 ? 5.55301   20.10090 -1.82019  1.000 15.50501  ? 145 CYS A O   1 
ATOM   1064 C CB  . CYS A 1 145 ? 6.87115   22.56240 -2.77473  1.000 15.49528  ? 145 CYS A CB  1 
ATOM   1065 S SG  . CYS A 1 145 ? 7.40780   23.33093 -1.25434  1.000 16.96604  ? 145 CYS A SG  1 
ATOM   1066 N N   . ASN A 1 146 ? 7.62807   19.41575 -1.23910  1.000 15.83163  ? 146 ASN A N   1 
ATOM   1067 C CA  . ASN A 1 146 ? 7.12600   18.44680 -0.26355  1.000 19.09565  ? 146 ASN A CA  1 
ATOM   1068 C C   . ASN A 1 146 ? 6.54711   19.12626 0.96987   1.000 15.00165  ? 146 ASN A C   1 
ATOM   1069 O O   . ASN A 1 146 ? 6.98310   20.20356 1.37135   1.000 17.79868  ? 146 ASN A O   1 
ATOM   1070 C CB  . ASN A 1 146 ? 8.24491   17.55614 0.24730   1.000 17.81876  ? 146 ASN A CB  1 
ATOM   1071 C CG  . ASN A 1 146 ? 8.69604   16.52186 -0.75857  1.000 26.44728  ? 146 ASN A CG  1 
ATOM   1072 O OD1 . ASN A 1 146 ? 7.90131   15.79922 -1.29931  1.000 24.69379  ? 146 ASN A OD1 1 
ATOM   1073 N ND2 . ASN A 1 146 ? 9.99270   16.44066 -0.96607  1.000 28.02224  ? 146 ASN A ND2 1 
ATOM   1074 N N   . ASP A 1 147 ? 5.62026   18.42147 1.62272   1.000 14.99099  ? 147 ASP A N   1 
ATOM   1075 C CA  . ASP A 1 147 ? 5.21485   18.79261 2.98332   1.000 15.05816  ? 147 ASP A CA  1 
ATOM   1076 C C   . ASP A 1 147 ? 6.27280   18.35365 3.98656   1.000 15.85423  ? 147 ASP A C   1 
ATOM   1077 O O   . ASP A 1 147 ? 7.08229   17.44096 3.72312   1.000 14.04919  ? 147 ASP A O   1 
ATOM   1078 C CB  . ASP A 1 147 ? 3.91063   18.11369 3.34610   1.000 15.94998  ? 147 ASP A CB  1 
ATOM   1079 C CG  . ASP A 1 147 ? 4.05074   16.62814 3.40612   1.000 16.06697  ? 147 ASP A CG  1 
ATOM   1080 O OD1 . ASP A 1 147 ? 4.12936   15.99533 2.34292   1.000 16.21129  ? 147 ASP A OD1 1 
ATOM   1081 O OD2 . ASP A 1 147 ? 4.14718   16.09356 4.54930   1.000 18.58921  ? 147 ASP A OD2 1 
ATOM   1082 N N   . ALA A 1 148 ? 6.21367   18.96480 5.19193   1.000 14.84942  ? 148 ALA A N   1 
ATOM   1083 C CA  . ALA A 1 148 ? 7.25668   18.71771 6.18595   1.000 18.19093  ? 148 ALA A CA  1 
ATOM   1084 C C   . ALA A 1 148 ? 7.15506   17.31940 6.78571   1.000 16.71557  ? 148 ALA A C   1 
ATOM   1085 O O   . ALA A 1 148 ? 8.17021   16.77261 7.27452   1.000 16.36206  ? 148 ALA A O   1 
ATOM   1086 C CB  . ALA A 1 148 ? 7.16803   19.77506 7.32083   1.000 17.80196  ? 148 ALA A CB  1 
ATOM   1087 N N   . CYS A 1 149 ? 5.95229   16.73787 6.82885   1.000 14.96004  ? 149 CYS A N   1 
ATOM   1088 C CA  . CYS A 1 149 ? 5.83323   15.38978 7.37309   1.000 15.40108  ? 149 CYS A CA  1 
ATOM   1089 C C   . CYS A 1 149 ? 6.56493   14.39259 6.48051   1.000 20.49516  ? 149 CYS A C   1 
ATOM   1090 O O   . CYS A 1 149 ? 7.37012   13.56953 6.94457   1.000 17.47429  ? 149 CYS A O   1 
ATOM   1091 C CB  . CYS A 1 149 ? 4.35111   15.02211 7.51946   1.000 17.00196  ? 149 CYS A CB  1 
ATOM   1092 S SG  . CYS A 1 149 ? 4.07270   13.28351 7.87330   1.000 18.99043  ? 149 CYS A SG  1 
ATOM   1093 N N   . THR A 1 150 ? 6.30678   14.46329 5.17967   1.000 15.41594  ? 150 THR A N   1 
ATOM   1094 C CA  . THR A 1 150 ? 7.03922   13.62117 4.22953   1.000 14.84774  ? 150 THR A CA  1 
ATOM   1095 C C   . THR A 1 150 ? 8.54468   13.74130 4.39347   1.000 17.69198  ? 150 THR A C   1 
ATOM   1096 O O   . THR A 1 150 ? 9.25337   12.73754 4.37845   1.000 19.45013  ? 150 THR A O   1 
ATOM   1097 C CB  . THR A 1 150 ? 6.63236   14.02375 2.80385   1.000 17.84417  ? 150 THR A CB  1 
ATOM   1098 O OG1 . THR A 1 150 ? 5.24992   13.69595 2.63205   1.000 17.99724  ? 150 THR A OG1 1 
ATOM   1099 C CG2 . THR A 1 150 ? 7.50099   13.29713 1.77719   1.000 20.12706  ? 150 THR A CG2 1 
ATOM   1100 N N   . VAL A 1 151 ? 9.05690   14.96571 4.50401   1.000 17.53545  ? 151 VAL A N   1 
ATOM   1101 C CA  . VAL A 1 151 ? 10.50750  15.16292 4.56003   1.000 18.19405  ? 151 VAL A CA  1 
ATOM   1102 C C   . VAL A 1 151 ? 11.09914  14.69131 5.89270   1.000 20.63359  ? 151 VAL A C   1 
ATOM   1103 O O   . VAL A 1 151 ? 12.13316  14.01277 5.91533   1.000 19.04850  ? 151 VAL A O   1 
ATOM   1104 C CB  . VAL A 1 151 ? 10.84757  16.63871 4.29968   1.000 14.76531  ? 151 VAL A CB  1 
ATOM   1105 C CG1 . VAL A 1 151 ? 12.33829  16.90041 4.49347   1.000 16.32853  ? 151 VAL A CG1 1 
ATOM   1106 C CG2 . VAL A 1 151 ? 10.41176  17.02222 2.85559   1.000 15.26859  ? 151 VAL A CG2 1 
ATOM   1107 N N   . PHE A 1 152 ? 10.51004  15.10648 7.01063   1.000 17.72651  ? 152 PHE A N   1 
ATOM   1108 C CA  . PHE A 1 152 ? 11.18538  15.00120 8.31476   1.000 17.19993  ? 152 PHE A CA  1 
ATOM   1109 C C   . PHE A 1 152 ? 10.64286  13.90401 9.22028   1.000 16.79557  ? 152 PHE A C   1 
ATOM   1110 O O   . PHE A 1 152 ? 11.33785  13.51379 10.16822  1.000 20.61236  ? 152 PHE A O   1 
ATOM   1111 C CB  . PHE A 1 152 ? 11.12759  16.34399 9.06808   1.000 14.15596  ? 152 PHE A CB  1 
ATOM   1112 C CG  . PHE A 1 152 ? 11.93636  17.41618 8.40988   1.000 16.10634  ? 152 PHE A CG  1 
ATOM   1113 C CD1 . PHE A 1 152 ? 13.31152  17.40945 8.48850   1.000 16.62896  ? 152 PHE A CD1 1 
ATOM   1114 C CD2 . PHE A 1 152 ? 11.31733  18.42983 7.69204   1.000 19.93916  ? 152 PHE A CD2 1 
ATOM   1115 C CE1 . PHE A 1 152 ? 14.09145  18.39943 7.88154   1.000 22.71859  ? 152 PHE A CE1 1 
ATOM   1116 C CE2 . PHE A 1 152 ? 12.09774  19.43411 7.07615   1.000 20.18025  ? 152 PHE A CE2 1 
ATOM   1117 C CZ  . PHE A 1 152 ? 13.47315  19.42553 7.17644   1.000 18.84703  ? 152 PHE A CZ  1 
ATOM   1118 N N   . GLN A 1 153 ? 9.41254   13.42277 8.98689   1.000 18.14291  ? 153 GLN A N   1 
ATOM   1119 C CA  . GLN A 1 153 ? 8.84004   12.26189 9.69473   1.000 13.61882  ? 153 GLN A CA  1 
ATOM   1120 C C   . GLN A 1 153 ? 8.86172   12.43808 11.22656  1.000 17.15969  ? 153 GLN A C   1 
ATOM   1121 O O   . GLN A 1 153 ? 9.30269   11.55623 11.95427  1.000 19.87103  ? 153 GLN A O   1 
ATOM   1122 C CB  . GLN A 1 153 ? 9.59551   10.98293 9.29232   1.000 16.42918  ? 153 GLN A CB  1 
ATOM   1123 C CG  . GLN A 1 153 ? 9.46496   10.65691 7.75185   1.000 20.85567  ? 153 GLN A CG  1 
ATOM   1124 C CD  . GLN A 1 153 ? 8.19584   9.91461  7.47634   1.000 30.42830  ? 153 GLN A CD  1 
ATOM   1125 O OE1 . GLN A 1 153 ? 8.15671   8.69842  7.64506   1.000 35.55409  ? 153 GLN A OE1 1 
ATOM   1126 N NE2 . GLN A 1 153 ? 7.12994   10.62560 7.03056   1.000 30.55885  ? 153 GLN A NE2 1 
ATOM   1127 N N   . THR A 1 154 ? 8.43449   13.59945 11.70792  1.000 17.95545  ? 154 THR A N   1 
ATOM   1128 C CA  . THR A 1 154 ? 8.31038   13.83551 13.14775  1.000 14.44782  ? 154 THR A CA  1 
ATOM   1129 C C   . THR A 1 154 ? 6.84946   13.79181 13.55690  1.000 19.40721  ? 154 THR A C   1 
ATOM   1130 O O   . THR A 1 154 ? 5.93007   14.01209 12.75046  1.000 15.87774  ? 154 THR A O   1 
ATOM   1131 C CB  . THR A 1 154 ? 8.88842   15.18716 13.57359  1.000 14.65289  ? 154 THR A CB  1 
ATOM   1132 O OG1 . THR A 1 154 ? 8.04378   16.23691 13.08491  1.000 18.35204  ? 154 THR A OG1 1 
ATOM   1133 C CG2 . THR A 1 154 ? 10.32943  15.37144 13.09030  1.000 20.43604  ? 154 THR A CG2 1 
ATOM   1134 N N   . SER A 1 155 ? 6.64300   13.53400 14.84921  1.000 16.02673  ? 155 SER A N   1 
ATOM   1135 C CA  . SER A 1 155 ? 5.27736   13.53648 15.38274  1.000 15.47765  ? 155 SER A CA  1 
ATOM   1136 C C   . SER A 1 155 ? 4.61992   14.90183 15.19778  1.000 17.15588  ? 155 SER A C   1 
ATOM   1137 O O   . SER A 1 155 ? 3.42792   14.97912 14.92182  1.000 18.51785  ? 155 SER A O   1 
ATOM   1138 C CB  . SER A 1 155 ? 5.27887   13.18994 16.87270  1.000 19.23843  ? 155 SER A CB  1 
ATOM   1139 O OG  . SER A 1 155 ? 5.63883   11.83793 17.03041  1.000 28.13337  ? 155 SER A OG  1 
ATOM   1140 N N   . GLU A 1 156 ? 5.38863   15.98443 15.32539  1.000 14.72095  ? 156 GLU A N   1 
ATOM   1141 C CA  . GLU A 1 156 ? 4.80876   17.32306 15.17591  1.000 15.39124  ? 156 GLU A CA  1 
ATOM   1142 C C   . GLU A 1 156 ? 4.33673   17.57636 13.74289  1.000 18.30208  ? 156 GLU A C   1 
ATOM   1143 O O   . GLU A 1 156 ? 3.21351   18.04040 13.53036  1.000 17.31785  ? 156 GLU A O   1 
ATOM   1144 C CB  . GLU A 1 156 ? 5.82859   18.39164 15.60586  1.000 16.30078  ? 156 GLU A CB  1 
ATOM   1145 C CG  . GLU A 1 156 ? 5.18966   19.78119 15.78353  1.000 18.51534  ? 156 GLU A CG  1 
ATOM   1146 C CD  . GLU A 1 156 ? 4.09068   19.82335 16.85202  1.000 20.38735  ? 156 GLU A CD  1 
ATOM   1147 O OE1 . GLU A 1 156 ? 4.00408   18.91263 17.69674  1.000 19.43021  ? 156 GLU A OE1 1 
ATOM   1148 O OE2 . GLU A 1 156 ? 3.31723   20.80496 16.87559  1.000 21.88812  ? 156 GLU A OE2 1 
ATOM   1149 N N   . TYR A 1 157 ? 5.17963   17.27644 12.73932  1.000 13.98101  ? 157 TYR A N   1 
ATOM   1150 C CA  . TYR A 1 157 ? 4.75376   17.59895 11.36438  1.000 16.73127  ? 157 TYR A CA  1 
ATOM   1151 C C   . TYR A 1 157 ? 3.64198   16.65959 10.89863  1.000 20.83170  ? 157 TYR A C   1 
ATOM   1152 O O   . TYR A 1 157 ? 2.78084   17.05425 10.09445  1.000 17.94310  ? 157 TYR A O   1 
ATOM   1153 C CB  . TYR A 1 157 ? 5.93696   17.49107 10.39111  1.000 14.69514  ? 157 TYR A CB  1 
ATOM   1154 C CG  . TYR A 1 157 ? 7.01227   18.53446 10.62903  1.000 17.25115  ? 157 TYR A CG  1 
ATOM   1155 C CD1 . TYR A 1 157 ? 6.68025   19.84232 10.92214  1.000 19.48402  ? 157 TYR A CD1 1 
ATOM   1156 C CD2 . TYR A 1 157 ? 8.34642   18.18231 10.57083  1.000 14.15079  ? 157 TYR A CD2 1 
ATOM   1157 C CE1 . TYR A 1 157 ? 7.66260   20.77973 11.12937  1.000 16.68863  ? 157 TYR A CE1 1 
ATOM   1158 C CE2 . TYR A 1 157 ? 9.34771   19.09773 10.78225  1.000 18.30872  ? 157 TYR A CE2 1 
ATOM   1159 C CZ  . TYR A 1 157 ? 8.98053   20.40317 11.09244  1.000 16.85122  ? 157 TYR A CZ  1 
ATOM   1160 O OH  . TYR A 1 157 ? 9.95414   21.33669 11.32934  1.000 16.82354  ? 157 TYR A OH  1 
ATOM   1161 N N   . CYS A 1 158 ? 3.71551   15.38967 11.30743  1.000 17.93885  ? 158 CYS A N   1 
ATOM   1162 C CA  . CYS A 1 158 ? 2.76468   14.37250 10.88141  1.000 19.15888  ? 158 CYS A CA  1 
ATOM   1163 C C   . CYS A 1 158 ? 1.53092   14.31854 11.77236  1.000 21.33975  ? 158 CYS A C   1 
ATOM   1164 O O   . CYS A 1 158 ? 0.56079   13.63971 11.40845  1.000 20.68134  ? 158 CYS A O   1 
ATOM   1165 C CB  . CYS A 1 158 ? 3.44326   12.99616 10.81689  1.000 16.67919  ? 158 CYS A CB  1 
ATOM   1166 S SG  . CYS A 1 158 ? 4.89307   12.99876 9.74625   1.000 18.63149  ? 158 CYS A SG  1 
ATOM   1167 N N   . CYS A 1 159 ? 1.54487   15.02705 12.91448  1.000 18.74225  ? 159 CYS A N   1 
ATOM   1168 C CA  A CYS A 1 159 ? 0.39500   15.10752 13.82237  0.620 18.57779  ? 159 CYS A CA  1 
ATOM   1169 C CA  B CYS A 1 159 ? 0.38986   15.10542 13.81701  0.380 18.65909  ? 159 CYS A CA  1 
ATOM   1170 C C   . CYS A 1 159 ? 0.01352   13.72445 14.34230  1.000 22.04744  ? 159 CYS A C   1 
ATOM   1171 O O   . CYS A 1 159 ? -1.15488  13.42320 14.55499  1.000 22.22630  ? 159 CYS A O   1 
ATOM   1172 C CB  A CYS A 1 159 ? -0.80654  15.76863 13.14899  0.620 20.42915  ? 159 CYS A CB  1 
ATOM   1173 C CB  B CYS A 1 159 ? -0.80285  15.76646 13.12385  0.380 20.42082  ? 159 CYS A CB  1 
ATOM   1174 S SG  A CYS A 1 159 ? -1.71817  16.69510 14.38130  0.620 23.52939  ? 159 CYS A SG  1 
ATOM   1175 S SG  B CYS A 1 159 ? -0.43094  17.46330 12.68520  0.380 20.70373  ? 159 CYS A SG  1 
ATOM   1176 N N   . THR A 1 160 ? 1.01667   12.89571 14.57382  1.000 18.70838  ? 160 THR A N   1 
ATOM   1177 C CA  . THR A 1 160 ? 0.77825   11.49076 14.87670  1.000 20.02958  ? 160 THR A CA  1 
ATOM   1178 C C   . THR A 1 160 ? 0.06135   11.29521 16.21207  1.000 24.64964  ? 160 THR A C   1 
ATOM   1179 O O   . THR A 1 160 ? -0.66439  10.30849 16.37568  1.000 32.35182  ? 160 THR A O   1 
ATOM   1180 C CB  . THR A 1 160 ? 2.10899   10.72567 14.85890  1.000 23.93830  ? 160 THR A CB  1 
ATOM   1181 O OG1 . THR A 1 160 ? 2.87257   11.08992 15.99054  1.000 47.35242  ? 160 THR A OG1 1 
ATOM   1182 C CG2 . THR A 1 160 ? 2.89037   11.13617 13.66891  1.000 22.07507  ? 160 THR A CG2 1 
ATOM   1183 N N   . THR A 1 161 ? 0.23969   12.20457 17.16015  1.000 28.20025  ? 161 THR A N   1 
ATOM   1184 C CA  . THR A 1 161 ? -0.42771  12.04535 18.44832  1.000 32.69426  ? 161 THR A CA  1 
ATOM   1185 C C   . THR A 1 161 ? -1.79979  12.68876 18.45987  1.000 39.52948  ? 161 THR A C   1 
ATOM   1186 O O   . THR A 1 161 ? -2.49237  12.57490 19.46201  1.000 39.62820  ? 161 THR A O   1 
ATOM   1187 C CB  . THR A 1 161 ? 0.41093   12.62246 19.58268  1.000 31.49899  ? 161 THR A CB  1 
ATOM   1188 O OG1 . THR A 1 161 ? 0.27195   14.03993 19.59708  1.000 32.57638  ? 161 THR A OG1 1 
ATOM   1189 C CG2 . THR A 1 161 ? 1.92957   12.29133 19.43420  1.000 32.01759  ? 161 THR A CG2 1 
ATOM   1190 N N   . GLY A 1 162 ? -2.22798  13.31820 17.36204  1.000 30.18962  ? 162 GLY A N   1 
ATOM   1191 C CA  . GLY A 1 162 ? -3.47406  14.03973 17.33376  1.000 35.77621  ? 162 GLY A CA  1 
ATOM   1192 C C   . GLY A 1 162 ? -3.37508  15.40795 17.95173  1.000 29.75021  ? 162 GLY A C   1 
ATOM   1193 O O   . GLY A 1 162 ? -4.35025  16.15829 17.94108  1.000 33.63124  ? 162 GLY A O   1 
ATOM   1194 N N   . LYS A 1 163 ? -2.21992  15.75514 18.48861  1.000 28.31402  ? 163 LYS A N   1 
ATOM   1195 C CA  . LYS A 1 163 ? -1.94221  17.09632 18.95400  1.000 28.24081  ? 163 LYS A CA  1 
ATOM   1196 C C   . LYS A 1 163 ? -0.75511  17.57301 18.13627  1.000 33.37432  ? 163 LYS A C   1 
ATOM   1197 O O   . LYS A 1 163 ? 0.28066   16.89672 18.07200  1.000 40.57343  ? 163 LYS A O   1 
ATOM   1198 C CB  . LYS A 1 163 ? -1.63779  17.12908 20.44820  1.000 32.25828  ? 163 LYS A CB  1 
ATOM   1199 N N   . CYS A 1 164 ? -0.92672  18.69382 17.47083  1.000 24.78291  ? 164 CYS A N   1 
ATOM   1200 C CA  . CYS A 1 164 ? 0.18283   19.31831 16.75728  1.000 20.91764  ? 164 CYS A CA  1 
ATOM   1201 C C   . CYS A 1 164 ? -0.27628  20.73713 16.50444  1.000 25.37555  ? 164 CYS A C   1 
ATOM   1202 O O   . CYS A 1 164 ? -1.47722  21.02918 16.55108  1.000 23.56391  ? 164 CYS A O   1 
ATOM   1203 C CB  . CYS A 1 164 ? 0.51375   18.58289 15.44506  1.000 17.17489  ? 164 CYS A CB  1 
ATOM   1204 S SG  . CYS A 1 164 ? -0.90711  18.55314 14.32633  1.000 24.91950  ? 164 CYS A SG  1 
ATOM   1205 N N   . GLY A 1 165 ? 0.68016   21.61416 16.24047  1.000 17.31085  ? 165 GLY A N   1 
ATOM   1206 C CA  . GLY A 1 165 ? 0.35774   22.98601 15.93857  1.000 18.57483  ? 165 GLY A CA  1 
ATOM   1207 C C   . GLY A 1 165 ? 0.84772   23.29362 14.53444  1.000 18.04366  ? 165 GLY A C   1 
ATOM   1208 O O   . GLY A 1 165 ? 1.50808   22.48134 13.91311  1.000 19.08889  ? 165 GLY A O   1 
ATOM   1209 N N   . PRO A 1 166 ? 0.53502   24.48545 14.03566  1.000 19.22249  ? 166 PRO A N   1 
ATOM   1210 C CA  . PRO A 1 166 ? 1.15604   24.96219 12.79444  1.000 18.62202  ? 166 PRO A CA  1 
ATOM   1211 C C   . PRO A 1 166 ? 2.65716   25.13502 13.00627  1.000 19.47985  ? 166 PRO A C   1 
ATOM   1212 O O   . PRO A 1 166 ? 3.14237   25.29621 14.13519  1.000 16.50869  ? 166 PRO A O   1 
ATOM   1213 C CB  . PRO A 1 166 ? 0.46386   26.30460 12.53506  1.000 19.44219  ? 166 PRO A CB  1 
ATOM   1214 C CG  . PRO A 1 166 ? -0.13786  26.71225 13.84248  1.000 25.78156  ? 166 PRO A CG  1 
ATOM   1215 C CD  . PRO A 1 166 ? -0.28875  25.49894 14.71694  1.000 20.10435  ? 166 PRO A CD  1 
ATOM   1216 N N   . THR A 1 167 ? 3.39852   25.09875 11.90838  1.000 16.23242  ? 167 THR A N   1 
ATOM   1217 C CA  . THR A 1 167 ? 4.85402   25.09555 11.93256  1.000 16.78207  ? 167 THR A CA  1 
ATOM   1218 C C   . THR A 1 167 ? 5.33323   26.10195 10.91303  1.000 18.10724  ? 167 THR A C   1 
ATOM   1219 O O   . THR A 1 167 ? 4.54284   26.61807 10.12403  1.000 19.05729  ? 167 THR A O   1 
ATOM   1220 C CB  . THR A 1 167 ? 5.40700   23.69044 11.61964  1.000 18.07074  ? 167 THR A CB  1 
ATOM   1221 O OG1 . THR A 1 167 ? 5.07810   23.39175 10.24124  1.000 17.86704  ? 167 THR A OG1 1 
ATOM   1222 C CG2 . THR A 1 167 ? 4.76051   22.62230 12.57609  1.000 14.90086  ? 167 THR A CG2 1 
ATOM   1223 N N   . GLU A 1 168 ? 6.63255   26.41664 10.93320  1.000 15.52547  ? 168 GLU A N   1 
ATOM   1224 C CA  A GLU A 1 168 ? 7.16213   27.30045 9.90997   0.576 19.12548  ? 168 GLU A CA  1 
ATOM   1225 C CA  B GLU A 1 168 ? 7.17133   27.29692 9.90794   0.424 19.16178  ? 168 GLU A CA  1 
ATOM   1226 C C   . GLU A 1 168 ? 6.82936   26.76976 8.51950   1.000 19.42234  ? 168 GLU A C   1 
ATOM   1227 O O   . GLU A 1 168 ? 6.51345   27.53891 7.60911   1.000 16.58699  ? 168 GLU A O   1 
ATOM   1228 C CB  A GLU A 1 168 ? 8.67539   27.46053 10.06694  0.576 21.02958  ? 168 GLU A CB  1 
ATOM   1229 C CB  B GLU A 1 168 ? 8.68858   27.43091 10.05581  0.424 21.03844  ? 168 GLU A CB  1 
ATOM   1230 C CG  A GLU A 1 168 ? 9.07133   28.56073 11.05838  0.576 34.63616  ? 168 GLU A CG  1 
ATOM   1231 C CG  B GLU A 1 168 ? 9.27879   28.62995 9.31069   0.424 32.87731  ? 168 GLU A CG  1 
ATOM   1232 C CD  A GLU A 1 168 ? 8.32551   29.87127 10.81395  0.576 37.97731  ? 168 GLU A CD  1 
ATOM   1233 C CD  B GLU A 1 168 ? 10.73725  28.85684 9.64621   0.424 42.26924  ? 168 GLU A CD  1 
ATOM   1234 O OE1 A GLU A 1 168 ? 8.72383   30.59568 9.88055   0.576 41.91731  ? 168 GLU A OE1 1 
ATOM   1235 O OE1 B GLU A 1 168 ? 11.60505  28.63012 8.77480   0.424 41.91731  ? 168 GLU A OE1 1 
ATOM   1236 O OE2 A GLU A 1 168 ? 7.31268   30.14145 11.53125  0.576 28.35731  ? 168 GLU A OE2 1 
ATOM   1237 O OE2 B GLU A 1 168 ? 11.01785  29.24300 10.79843  0.424 41.52450  ? 168 GLU A OE2 1 
ATOM   1238 N N   . TYR A 1 169 ? 6.89729   25.45001 8.34644   1.000 15.66276  ? 169 TYR A N   1 
ATOM   1239 C CA  . TYR A 1 169 ? 6.64361   24.89830 7.02594   1.000 15.31764  ? 169 TYR A CA  1 
ATOM   1240 C C   . TYR A 1 169 ? 5.16565   24.94192 6.67743   1.000 17.02019  ? 169 TYR A C   1 
ATOM   1241 O O   . TYR A 1 169 ? 4.81544   25.30355 5.54781   1.000 19.33653  ? 169 TYR A O   1 
ATOM   1242 C CB  . TYR A 1 169 ? 7.18231   23.47596 6.94731   1.000 14.26887  ? 169 TYR A CB  1 
ATOM   1243 C CG  . TYR A 1 169 ? 8.68891   23.40654 7.12260   1.000 17.17053  ? 169 TYR A CG  1 
ATOM   1244 C CD1 . TYR A 1 169 ? 9.53133   24.03708 6.23002   1.000 18.37103  ? 169 TYR A CD1 1 
ATOM   1245 C CD2 . TYR A 1 169 ? 9.24921   22.63295 8.14243   1.000 15.04969  ? 169 TYR A CD2 1 
ATOM   1246 C CE1 . TYR A 1 169 ? 10.89608  23.96189 6.37015   1.000 18.54534  ? 169 TYR A CE1 1 
ATOM   1247 C CE2 . TYR A 1 169 ? 10.60868  22.53757 8.28527   1.000 14.42171  ? 169 TYR A CE2 1 
ATOM   1248 C CZ  . TYR A 1 169 ? 11.42998  23.20248 7.38223   1.000 19.67055  ? 169 TYR A CZ  1 
ATOM   1249 O OH  . TYR A 1 169 ? 12.78850  23.09562 7.54009   1.000 21.06953  ? 169 TYR A OH  1 
ATOM   1250 N N   . SER A 1 170 ? 4.27924   24.60284 7.62511   1.000 15.81067  ? 170 SER A N   1 
ATOM   1251 C CA  . SER A 1 170 ? 2.86519   24.64238 7.27352   1.000 19.32660  ? 170 SER A CA  1 
ATOM   1252 C C   . SER A 1 170 ? 2.43653   26.06882 6.96350   1.000 18.16191  ? 170 SER A C   1 
ATOM   1253 O O   . SER A 1 170 ? 1.61320   26.29886 6.06135   1.000 17.83408  ? 170 SER A O   1 
ATOM   1254 C CB  . SER A 1 170 ? 2.00636   24.04958 8.38853   1.000 14.22371  ? 170 SER A CB  1 
ATOM   1255 O OG  . SER A 1 170 ? 1.91070   24.91228 9.53517   1.000 17.08994  ? 170 SER A OG  1 
ATOM   1256 N N   . ARG A 1 171 ? 3.01227   27.06034 7.68118   1.000 14.26416  ? 171 ARG A N   1 
ATOM   1257 C CA  . ARG A 1 171 ? 2.60543   28.46015 7.44297   1.000 16.50619  ? 171 ARG A CA  1 
ATOM   1258 C C   . ARG A 1 171 ? 3.03541   28.96376 6.07642   1.000 17.54257  ? 171 ARG A C   1 
ATOM   1259 O O   . ARG A 1 171 ? 2.39929   29.87628 5.53504   1.000 20.26714  ? 171 ARG A O   1 
ATOM   1260 C CB  . ARG A 1 171 ? 3.21452   29.39597 8.51925   1.000 17.24919  ? 171 ARG A CB  1 
ATOM   1261 C CG  . ARG A 1 171 ? 2.57574   29.17590 9.87728   1.000 19.26576  ? 171 ARG A CG  1 
ATOM   1262 C CD  . ARG A 1 171 ? 3.27004   30.19942 10.85805  1.000 18.29892  ? 171 ARG A CD  1 
ATOM   1263 N NE  . ARG A 1 171 ? 2.70496   30.01248 12.16519  1.000 27.34756  ? 171 ARG A NE  1 
ATOM   1264 C CZ  . ARG A 1 171 ? 3.27021   29.29665 13.11669  1.000 22.80592  ? 171 ARG A CZ  1 
ATOM   1265 N NH1 . ARG A 1 171 ? 4.47564   28.77660 12.96020  1.000 26.22723  ? 171 ARG A NH1 1 
ATOM   1266 N NH2 . ARG A 1 171 ? 2.62618   29.13661 14.26992  1.000 31.19622  ? 171 ARG A NH2 1 
ATOM   1267 N N   . PHE A 1 172 ? 4.10047   28.40289 5.51267   1.000 17.61268  ? 172 PHE A N   1 
ATOM   1268 C CA  . PHE A 1 172 ? 4.47194   28.72955 4.14747   1.000 17.18868  ? 172 PHE A CA  1 
ATOM   1269 C C   . PHE A 1 172 ? 3.34664   28.33957 3.18026   1.000 19.71038  ? 172 PHE A C   1 
ATOM   1270 O O   . PHE A 1 172 ? 2.90679   29.14849 2.35769   1.000 17.73803  ? 172 PHE A O   1 
ATOM   1271 C CB  . PHE A 1 172 ? 5.77350   28.00482 3.76923   1.000 18.54743  ? 172 PHE A CB  1 
ATOM   1272 C CG  . PHE A 1 172 ? 5.97453   27.90759 2.28929   1.000 17.42511  ? 172 PHE A CG  1 
ATOM   1273 C CD1 . PHE A 1 172 ? 6.37753   29.03979 1.58675   1.000 18.38049  ? 172 PHE A CD1 1 
ATOM   1274 C CD2 . PHE A 1 172 ? 5.70982   26.69825 1.59577   1.000 17.33500  ? 172 PHE A CD2 1 
ATOM   1275 C CE1 . PHE A 1 172 ? 6.53107   28.99701 0.17422   1.000 23.82069  ? 172 PHE A CE1 1 
ATOM   1276 C CE2 . PHE A 1 172 ? 5.85870   26.64293 0.18698   1.000 19.38030  ? 172 PHE A CE2 1 
ATOM   1277 C CZ  . PHE A 1 172 ? 6.28911   27.79662 -0.50921  1.000 20.89276  ? 172 PHE A CZ  1 
ATOM   1278 N N   . PHE A 1 173 ? 2.86129   27.08808 3.27883   1.000 17.23764  ? 173 PHE A N   1 
ATOM   1279 C CA  . PHE A 1 173 ? 1.80958   26.67663 2.36340   1.000 16.87158  ? 173 PHE A CA  1 
ATOM   1280 C C   . PHE A 1 173 ? 0.56008   27.51208 2.59416   1.000 14.54551  ? 173 PHE A C   1 
ATOM   1281 O O   . PHE A 1 173 ? -0.11608  27.89735 1.63777   1.000 18.11800  ? 173 PHE A O   1 
ATOM   1282 C CB  . PHE A 1 173 ? 1.47543   25.18814 2.51951   1.000 14.14418  ? 173 PHE A CB  1 
ATOM   1283 C CG  . PHE A 1 173 ? 2.55026   24.25187 1.99965   1.000 15.93989  ? 173 PHE A CG  1 
ATOM   1284 C CD1 . PHE A 1 173 ? 2.54440   23.87397 0.66778   1.000 17.53268  ? 173 PHE A CD1 1 
ATOM   1285 C CD2 . PHE A 1 173 ? 3.53948   23.75945 2.83487   1.000 16.42917  ? 173 PHE A CD2 1 
ATOM   1286 C CE1 . PHE A 1 173 ? 3.52988   23.01854 0.16548   1.000 20.53206  ? 173 PHE A CE1 1 
ATOM   1287 C CE2 . PHE A 1 173 ? 4.55245   22.91799 2.35484   1.000 15.33399  ? 173 PHE A CE2 1 
ATOM   1288 C CZ  . PHE A 1 173 ? 4.52822   22.52826 0.99736   1.000 19.69061  ? 173 PHE A CZ  1 
ATOM   1289 N N   . LYS A 1 174 ? 0.25955   27.80027 3.85096   1.000 12.80110  ? 174 LYS A N   1 
ATOM   1290 C CA  . LYS A 1 174 ? -0.93300  28.54795 4.21398   1.000 15.65477  ? 174 LYS A CA  1 
ATOM   1291 C C   . LYS A 1 174 ? -0.85855  29.99549 3.73875   1.000 18.00360  ? 174 LYS A C   1 
ATOM   1292 O O   . LYS A 1 174 ? -1.86180  30.54649 3.29754   1.000 20.43188  ? 174 LYS A O   1 
ATOM   1293 C CB  . LYS A 1 174 ? -1.16382  28.49154 5.73189   1.000 17.73403  ? 174 LYS A CB  1 
ATOM   1294 C CG  . LYS A 1 174 ? -2.57040  28.91302 6.12916   1.000 19.55841  ? 174 LYS A CG  1 
ATOM   1295 C CD  . LYS A 1 174 ? -3.58029  27.92991 5.54858   1.000 20.60507  ? 174 LYS A CD  1 
ATOM   1296 C CE  . LYS A 1 174 ? -4.97730  28.11596 6.19689   1.000 21.64020  ? 174 LYS A CE  1 
ATOM   1297 N NZ  . LYS A 1 174 ? -5.88309  26.97491 5.74095   1.000 21.34717  ? 174 LYS A NZ  1 
ATOM   1298 N N   . ARG A 1 175 ? 0.33802   30.59545 3.75001   1.000 18.35393  ? 175 ARG A N   1 
ATOM   1299 C CA  . ARG A 1 175 ? 0.49399   31.97977 3.30872   1.000 17.69353  ? 175 ARG A CA  1 
ATOM   1300 C C   . ARG A 1 175 ? 0.20572   32.10088 1.81023   1.000 22.48404  ? 175 ARG A C   1 
ATOM   1301 O O   . ARG A 1 175 ? -0.46800  33.03329 1.37842   1.000 21.11107  ? 175 ARG A O   1 
ATOM   1302 C CB  . ARG A 1 175 ? 1.91819   32.44249 3.62871   1.000 22.91693  ? 175 ARG A CB  1 
ATOM   1303 C CG  . ARG A 1 175 ? 2.28481   33.78131 3.11171   1.000 28.04622  ? 175 ARG A CG  1 
ATOM   1304 C CD  . ARG A 1 175 ? 3.66753   34.23282 3.69109   1.000 29.17026  ? 175 ARG A CD  1 
ATOM   1305 N NE  . ARG A 1 175 ? 4.84323   33.47919 3.22620   1.000 34.96725  ? 175 ARG A NE  1 
ATOM   1306 C CZ  . ARG A 1 175 ? 5.45994   33.66220 2.05708   1.000 35.67952  ? 175 ARG A CZ  1 
ATOM   1307 N NH1 . ARG A 1 175 ? 4.97419   34.48954 1.12477   1.000 37.47186  ? 175 ARG A NH1 1 
ATOM   1308 N NH2 . ARG A 1 175 ? 6.60322   33.01821 1.81710   1.000 35.34609  ? 175 ARG A NH2 1 
ATOM   1309 N N   . LEU A 1 176 ? 0.66557   31.12345 1.02586   1.000 17.87571  ? 176 LEU A N   1 
ATOM   1310 C CA  A LEU A 1 176 ? 0.46881   31.14977 -0.42086  0.471 19.40707  ? 176 LEU A CA  1 
ATOM   1311 C CA  B LEU A 1 176 ? 0.46468   31.16339 -0.42005  0.529 19.41117  ? 176 LEU A CA  1 
ATOM   1312 C C   . LEU A 1 176 ? -0.91680  30.65222 -0.83265  1.000 23.92547  ? 176 LEU A C   1 
ATOM   1313 O O   . LEU A 1 176 ? -1.48595  31.14543 -1.83665  1.000 21.23605  ? 176 LEU A O   1 
ATOM   1314 C CB  A LEU A 1 176 ? 1.55942   30.32068 -1.08328  0.471 17.69535  ? 176 LEU A CB  1 
ATOM   1315 C CB  B LEU A 1 176 ? 1.56715   30.36957 -1.11104  0.529 17.74872  ? 176 LEU A CB  1 
ATOM   1316 C CG  A LEU A 1 176 ? 2.90257   31.04037 -0.94549  0.471 22.50680  ? 176 LEU A CG  1 
ATOM   1317 C CG  B LEU A 1 176 ? 2.72990   31.31876 -1.45229  0.529 23.12051  ? 176 LEU A CG  1 
ATOM   1318 C CD1 A LEU A 1 176 ? 3.99775   30.26911 -1.63435  0.471 19.47740  ? 176 LEU A CD1 1 
ATOM   1319 C CD1 B LEU A 1 176 ? 3.52263   31.71831 -0.20955  0.529 22.56863  ? 176 LEU A CD1 1 
ATOM   1320 C CD2 A LEU A 1 176 ? 2.78362   32.44879 -1.50865  0.471 26.17527  ? 176 LEU A CD2 1 
ATOM   1321 C CD2 B LEU A 1 176 ? 3.64725   30.77686 -2.55560  0.529 21.95614  ? 176 LEU A CD2 1 
ATOM   1322 N N   . CYS A 1 177 ? -1.47923  29.69441 -0.09994  1.000 17.81235  ? 177 CYS A N   1 
ATOM   1323 C CA  . CYS A 1 177 ? -2.79386  29.12312 -0.42016  1.000 17.83730  ? 177 CYS A CA  1 
ATOM   1324 C C   . CYS A 1 177 ? -3.64664  29.00000 0.82968   1.000 18.91995  ? 177 CYS A C   1 
ATOM   1325 O O   . CYS A 1 177 ? -3.74789  27.92500 1.44348   1.000 18.11039  ? 177 CYS A O   1 
ATOM   1326 C CB  . CYS A 1 177 ? -2.64825  27.75932 -1.10383  1.000 18.66897  ? 177 CYS A CB  1 
ATOM   1327 S SG  . CYS A 1 177 ? -2.17275  27.98057 -2.79992  1.000 20.35521  ? 177 CYS A SG  1 
ATOM   1328 N N   . PRO A 1 178 ? -4.30044  30.09757 1.23221   1.000 21.05373  ? 178 PRO A N   1 
ATOM   1329 C CA  . PRO A 1 178 ? -5.10138  30.08035 2.46298   1.000 22.31977  ? 178 PRO A CA  1 
ATOM   1330 C C   . PRO A 1 178 ? -6.30614  29.15107 2.40215   1.000 19.03151  ? 178 PRO A C   1 
ATOM   1331 O O   . PRO A 1 178 ? -6.77814  28.71732 3.45630   1.000 21.24300  ? 178 PRO A O   1 
ATOM   1332 C CB  . PRO A 1 178 ? -5.56434  31.54237 2.60976   1.000 22.76583  ? 178 PRO A CB  1 
ATOM   1333 C CG  . PRO A 1 178 ? -4.70680  32.32427 1.67829   1.000 25.40635  ? 178 PRO A CG  1 
ATOM   1334 C CD  . PRO A 1 178 ? -4.25041  31.43499 0.59288   1.000 21.79123  ? 178 PRO A CD  1 
ATOM   1335 N N   . ASP A 1 179 ? -6.82206  28.84376 1.20800   1.000 20.35071  ? 179 ASP A N   1 
ATOM   1336 C CA  . ASP A 1 179 ? -8.00757  28.00864 1.08697   1.000 22.60470  ? 179 ASP A CA  1 
ATOM   1337 C C   . ASP A 1 179 ? -7.70666  26.53158 0.95667   1.000 21.56681  ? 179 ASP A C   1 
ATOM   1338 O O   . ASP A 1 179 ? -8.61523  25.77477 0.63513   1.000 27.79970  ? 179 ASP A O   1 
ATOM   1339 C CB  . ASP A 1 179 ? -8.84382  28.43746 -0.11285  1.000 27.27384  ? 179 ASP A CB  1 
ATOM   1340 C CG  . ASP A 1 179 ? -9.49595  29.78199 0.11442   1.000 45.02327  ? 179 ASP A CG  1 
ATOM   1341 O OD1 . ASP A 1 179 ? -9.73936  30.17386 1.31087   1.000 42.14403  ? 179 ASP A OD1 1 
ATOM   1342 O OD2 . ASP A 1 179 ? -9.73005  30.46921 -0.88807  1.000 42.78879  ? 179 ASP A OD2 1 
ATOM   1343 N N   . ALA A 1 180 ? -6.47054  26.11011 1.18119   1.000 19.37037  ? 180 ALA A N   1 
ATOM   1344 C CA  . ALA A 1 180 ? -6.09337  24.70644 1.17536   1.000 17.18752  ? 180 ALA A CA  1 
ATOM   1345 C C   . ALA A 1 180 ? -5.60366  24.31624 2.55838   1.000 21.11286  ? 180 ALA A C   1 
ATOM   1346 O O   . ALA A 1 180 ? -4.98751  25.12743 3.24596   1.000 18.45253  ? 180 ALA A O   1 
ATOM   1347 C CB  . ALA A 1 180 ? -4.98477  24.42579 0.18654   1.000 17.88998  ? 180 ALA A CB  1 
ATOM   1348 N N   . PHE A 1 181 ? -5.86567  23.06961 2.95113   1.000 15.68238  ? 181 PHE A N   1 
ATOM   1349 C CA  . PHE A 1 181 ? -5.30914  22.53922 4.19523   1.000 18.44918  ? 181 PHE A CA  1 
ATOM   1350 C C   . PHE A 1 181 ? -3.79324  22.58293 4.16460   1.000 18.66815  ? 181 PHE A C   1 
ATOM   1351 O O   . PHE A 1 181 ? -3.18221  22.09949 3.21401   1.000 17.95253  ? 181 PHE A O   1 
ATOM   1352 C CB  . PHE A 1 181 ? -5.71719  21.10681 4.40550   1.000 15.74353  ? 181 PHE A CB  1 
ATOM   1353 C CG  . PHE A 1 181 ? -7.11127  20.94044 4.92320   1.000 20.32891  ? 181 PHE A CG  1 
ATOM   1354 C CD1 . PHE A 1 181 ? -8.18473  20.91684 4.04770   1.000 22.46275  ? 181 PHE A CD1 1 
ATOM   1355 C CD2 . PHE A 1 181 ? -7.33253  20.75744 6.27706   1.000 22.69794  ? 181 PHE A CD2 1 
ATOM   1356 C CE1 . PHE A 1 181 ? -9.48662  20.72368 4.51537   1.000 27.10313  ? 181 PHE A CE1 1 
ATOM   1357 C CE2 . PHE A 1 181 ? -8.61946  20.59247 6.77888   1.000 25.02736  ? 181 PHE A CE2 1 
ATOM   1358 C CZ  . PHE A 1 181 ? -9.71193  20.55824 5.90791   1.000 21.17977  ? 181 PHE A CZ  1 
ATOM   1359 N N   . SER A 1 182 ? -3.18475  23.12827 5.22724   1.000 13.95451  ? 182 SER A N   1 
ATOM   1360 C CA  . SER A 1 182 ? -1.72191  23.17880 5.28278   1.000 14.48248  ? 182 SER A CA  1 
ATOM   1361 C C   . SER A 1 182 ? -1.11175  22.20178 6.27357   1.000 19.55339  ? 182 SER A C   1 
ATOM   1362 O O   . SER A 1 182 ? 0.08550   21.91725 6.18205   1.000 20.09088  ? 182 SER A O   1 
ATOM   1363 C CB  . SER A 1 182 ? -1.25056  24.60042 5.59537   1.000 18.63676  ? 182 SER A CB  1 
ATOM   1364 O OG  . SER A 1 182 ? -1.62139  24.95075 6.92744   1.000 17.78739  ? 182 SER A OG  1 
ATOM   1365 N N   . TYR A 1 183 ? -1.88574  21.68986 7.21026   1.000 17.27566  ? 183 TYR A N   1 
ATOM   1366 C CA  . TYR A 1 183 ? -1.41138  20.62891 8.08292   1.000 19.27495  ? 183 TYR A CA  1 
ATOM   1367 C C   . TYR A 1 183 ? -2.65122  19.90670 8.59805   1.000 20.51704  ? 183 TYR A C   1 
ATOM   1368 O O   . TYR A 1 183 ? -3.77872  20.32893 8.34698   1.000 20.86325  ? 183 TYR A O   1 
ATOM   1369 C CB  . TYR A 1 183 ? -0.51478  21.18822 9.21899   1.000 17.04459  ? 183 TYR A CB  1 
ATOM   1370 C CG  . TYR A 1 183 ? -1.22013  21.98497 10.30414  1.000 22.70144  ? 183 TYR A CG  1 
ATOM   1371 C CD1 . TYR A 1 183 ? -1.65607  23.29662 10.07092  1.000 19.14470  ? 183 TYR A CD1 1 
ATOM   1372 C CD2 . TYR A 1 183 ? -1.40776  21.44269 11.60516  1.000 18.60421  ? 183 TYR A CD2 1 
ATOM   1373 C CE1 . TYR A 1 183 ? -2.28537  24.04382 11.05367  1.000 22.70655  ? 183 TYR A CE1 1 
ATOM   1374 C CE2 . TYR A 1 183 ? -2.05098  22.22143 12.61780  1.000 19.59632  ? 183 TYR A CE2 1 
ATOM   1375 C CZ  . TYR A 1 183 ? -2.48036  23.49167 12.31544  1.000 25.61839  ? 183 TYR A CZ  1 
ATOM   1376 O OH  . TYR A 1 183 ? -3.09918  24.21372 13.28757  1.000 28.17081  ? 183 TYR A OH  1 
ATOM   1377 N N   . VAL A 1 184 ? -2.43732  18.79006 9.28716   1.000 23.45700  ? 184 VAL A N   1 
ATOM   1378 C CA  . VAL A 1 184 ? -3.55474  17.89176 9.61489   1.000 26.41199  ? 184 VAL A CA  1 
ATOM   1379 C C   . VAL A 1 184 ? -4.63779  18.60613 10.41601  1.000 23.09679  ? 184 VAL A C   1 
ATOM   1380 O O   . VAL A 1 184 ? -5.83068  18.43282 10.14920  1.000 28.69014  ? 184 VAL A O   1 
ATOM   1381 C CB  . VAL A 1 184 ? -3.02913  16.65051 10.35806  1.000 30.15785  ? 184 VAL A CB  1 
ATOM   1382 C CG1 . VAL A 1 184 ? -4.19065  15.80613 10.88041  1.000 27.47072  ? 184 VAL A CG1 1 
ATOM   1383 C CG2 . VAL A 1 184 ? -2.17125  15.85411 9.44493   1.000 27.91246  ? 184 VAL A CG2 1 
ATOM   1384 N N   . LEU A 1 185 ? -4.26680  19.45626 11.36803  1.000 21.56082  ? 185 LEU A N   1 
ATOM   1385 C CA  . LEU A 1 185 ? -5.27333  20.06978 12.22130  1.000 22.47744  ? 185 LEU A CA  1 
ATOM   1386 C C   . LEU A 1 185 ? -5.55554  21.50180 11.83627  1.000 27.51687  ? 185 LEU A C   1 
ATOM   1387 O O   . LEU A 1 185 ? -6.00807  22.28389 12.66637  1.000 23.69036  ? 185 LEU A O   1 
ATOM   1388 C CB  . LEU A 1 185 ? -4.85517  20.01141 13.69678  1.000 26.31670  ? 185 LEU A CB  1 
ATOM   1389 C CG  . LEU A 1 185 ? -4.91195  18.66045 14.39468  1.000 30.70687  ? 185 LEU A CG  1 
ATOM   1390 C CD1 . LEU A 1 185 ? -4.54398  18.84210 15.87600  1.000 30.21562  ? 185 LEU A CD1 1 
ATOM   1391 C CD2 . LEU A 1 185 ? -6.27794  18.03066 14.23480  1.000 40.03474  ? 185 LEU A CD2 1 
ATOM   1392 N N   . ASP A 1 186 ? -5.29493  21.86774 10.59247  1.000 22.25941  ? 186 ASP A N   1 
ATOM   1393 C CA  . ASP A 1 186 ? -5.60189  23.20085 10.13008  1.000 17.87273  ? 186 ASP A CA  1 
ATOM   1394 C C   . ASP A 1 186 ? -7.10076  23.49123 10.31327  1.000 22.84432  ? 186 ASP A C   1 
ATOM   1395 O O   . ASP A 1 186 ? -7.93276  22.57816 10.28336  1.000 28.57969  ? 186 ASP A O   1 
ATOM   1396 C CB  . ASP A 1 186 ? -5.17676  23.27929 8.65880   1.000 19.54728  ? 186 ASP A CB  1 
ATOM   1397 C CG  . ASP A 1 186 ? -4.85196  24.68809 8.20499   1.000 22.38794  ? 186 ASP A CG  1 
ATOM   1398 O OD1 . ASP A 1 186 ? -5.04218  25.64852 8.96536   1.000 23.07288  ? 186 ASP A OD1 1 
ATOM   1399 O OD2 . ASP A 1 186 ? -4.39787  24.83278 7.05984   1.000 22.04208  ? 186 ASP A OD2 1 
ATOM   1400 N N   . LYS A 1 187 ? -7.43289  24.75233 10.56960  1.000 23.35304  ? 187 LYS A N   1 
ATOM   1401 C CA  . LYS A 1 187 ? -8.83393  25.16752 10.56163  1.000 25.34477  ? 187 LYS A CA  1 
ATOM   1402 C C   . LYS A 1 187 ? -9.44144  24.75705 9.21050   1.000 28.67689  ? 187 LYS A C   1 
ATOM   1403 O O   . LYS A 1 187 ? -8.90164  25.13701 8.15936   1.000 29.36379  ? 187 LYS A O   1 
ATOM   1404 C CB  . LYS A 1 187 ? -8.95552  26.68177 10.75585  1.000 27.89932  ? 187 LYS A CB  1 
ATOM   1405 N N   . PRO A 1 188 ? -10.50665 23.96238 9.18825   1.000 29.58446  ? 188 PRO A N   1 
ATOM   1406 C CA  . PRO A 1 188 ? -10.90745 23.32962 7.92477   1.000 29.31807  ? 188 PRO A CA  1 
ATOM   1407 C C   . PRO A 1 188 ? -11.33011 24.34333 6.88436   1.000 29.76137  ? 188 PRO A C   1 
ATOM   1408 O O   . PRO A 1 188 ? -11.96549 25.35870 7.17033   1.000 28.25641  ? 188 PRO A O   1 
ATOM   1409 C CB  . PRO A 1 188 ? -12.07283 22.40746 8.32066   1.000 27.43845  ? 188 PRO A CB  1 
ATOM   1410 C CG  . PRO A 1 188 ? -11.85999 22.13734 9.76813   1.000 35.79669  ? 188 PRO A CG  1 
ATOM   1411 C CD  . PRO A 1 188 ? -11.28171 23.44012 10.32526  1.000 34.47667  ? 188 PRO A CD  1 
ATOM   1412 N N   . THR A 1 189 ? -10.94415 24.06041 5.65169   1.000 26.63955  ? 189 THR A N   1 
ATOM   1413 C CA  . THR A 1 189 ? -11.37963 24.86407 4.51332   1.000 23.92175  ? 189 THR A CA  1 
ATOM   1414 C C   . THR A 1 189 ? -12.29955 24.07567 3.60013   1.000 22.47951  ? 189 THR A C   1 
ATOM   1415 O O   . THR A 1 189 ? -12.41439 24.40010 2.40602   1.000 25.96999  ? 189 THR A O   1 
ATOM   1416 C CB  . THR A 1 189 ? -10.16729 25.34855 3.73047   1.000 25.90718  ? 189 THR A CB  1 
ATOM   1417 O OG1 . THR A 1 189 ? -9.29547  24.23260 3.52433   1.000 28.49970  ? 189 THR A OG1 1 
ATOM   1418 C CG2 . THR A 1 189 ? -9.44238  26.44078 4.51828   1.000 29.46887  ? 189 THR A CG2 1 
ATOM   1419 N N   . THR A 1 190 ? -12.88747 23.00897 4.13187   1.000 25.45600  ? 190 THR A N   1 
ATOM   1420 C CA  . THR A 1 190 ? -13.88931 22.22702 3.42517   1.000 22.38185  ? 190 THR A CA  1 
ATOM   1421 C C   . THR A 1 190 ? -15.06096 23.10017 3.01496   1.000 28.50761  ? 190 THR A C   1 
ATOM   1422 O O   . THR A 1 190 ? -15.54852 23.91472 3.79997   1.000 28.16992  ? 190 THR A O   1 
ATOM   1423 C CB  . THR A 1 190 ? -14.36082 21.10943 4.35143   1.000 25.19347  ? 190 THR A CB  1 
ATOM   1424 O OG1 . THR A 1 190 ? -13.17670 20.50117 4.85976   1.000 31.52047  ? 190 THR A OG1 1 
ATOM   1425 C CG2 . THR A 1 190 ? -15.19624 20.07521 3.58721   1.000 21.05560  ? 190 THR A CG2 1 
ATOM   1426 N N   . VAL A 1 191 ? -15.53474 22.88461 1.80236   1.000 19.95640  ? 191 VAL A N   1 
ATOM   1427 C CA  . VAL A 1 191 ? -16.78185 23.46600 1.30106   1.000 23.91150  ? 191 VAL A CA  1 
ATOM   1428 C C   . VAL A 1 191 ? -17.87885 22.41626 1.32271   1.000 26.15048  ? 191 VAL A C   1 
ATOM   1429 O O   . VAL A 1 191 ? -17.68355 21.27077 0.87260   1.000 24.99698  ? 191 VAL A O   1 
ATOM   1430 C CB  . VAL A 1 191 ? -16.60918 23.99936 -0.14043  1.000 27.65951  ? 191 VAL A CB  1 
ATOM   1431 C CG1 . VAL A 1 191 ? -17.96412 24.56556 -0.65799  1.000 21.95234  ? 191 VAL A CG1 1 
ATOM   1432 C CG2 . VAL A 1 191 ? -15.53205 25.04289 -0.16107  1.000 29.56781  ? 191 VAL A CG2 1 
ATOM   1433 N N   . THR A 1 192 ? -19.07760 22.82729 1.76152   1.000 21.90988  ? 192 THR A N   1 
ATOM   1434 C CA  . THR A 1 192 ? -20.24997 21.95135 1.76161   1.000 21.24317  ? 192 THR A CA  1 
ATOM   1435 C C   . THR A 1 192 ? -21.07712 22.29566 0.53060   1.000 20.97630  ? 192 THR A C   1 
ATOM   1436 O O   . THR A 1 192 ? -21.44447 23.45671 0.34258   1.000 26.86260  ? 192 THR A O   1 
ATOM   1437 C CB  . THR A 1 192 ? -21.08379 22.14375 3.04455   1.000 25.85795  ? 192 THR A CB  1 
ATOM   1438 O OG1 . THR A 1 192 ? -20.24247 21.96893 4.19099   1.000 29.44683  ? 192 THR A OG1 1 
ATOM   1439 C CG2 . THR A 1 192 ? -22.22887 21.14150 3.09320   1.000 28.16084  ? 192 THR A CG2 1 
ATOM   1440 N N   . CYS A 1 193 ? -21.30315 21.31232 -0.32353  1.000 22.46017  ? 193 CYS A N   1 
ATOM   1441 C CA  . CYS A 1 193 ? -22.13579 21.46374 -1.50767  1.000 21.87502  ? 193 CYS A CA  1 
ATOM   1442 C C   . CYS A 1 193 ? -23.37324 20.59533 -1.36269  1.000 25.19860  ? 193 CYS A C   1 
ATOM   1443 O O   . CYS A 1 193 ? -23.37591 19.64263 -0.58390  1.000 23.92505  ? 193 CYS A O   1 
ATOM   1444 C CB  . CYS A 1 193 ? -21.37722 21.02356 -2.76506  1.000 20.84417  ? 193 CYS A CB  1 
ATOM   1445 S SG  . CYS A 1 193 ? -20.04319 22.11903 -3.14673  1.000 25.73391  ? 193 CYS A SG  1 
ATOM   1446 N N   . PRO A 1 194 ? -24.42737 20.86124 -2.13675  1.000 30.11342  ? 194 PRO A N   1 
ATOM   1447 C CA  . PRO A 1 194 ? -25.57461 19.93639 -2.15213  1.000 29.07775  ? 194 PRO A CA  1 
ATOM   1448 C C   . PRO A 1 194 ? -25.12011 18.54637 -2.52583  1.000 27.43871  ? 194 PRO A C   1 
ATOM   1449 O O   . PRO A 1 194 ? -24.24442 18.38326 -3.37284  1.000 23.89682  ? 194 PRO A O   1 
ATOM   1450 C CB  . PRO A 1 194 ? -26.48660 20.51643 -3.23874  1.000 31.77795  ? 194 PRO A CB  1 
ATOM   1451 C CG  . PRO A 1 194 ? -26.15271 21.94318 -3.30132  1.000 26.30767  ? 194 PRO A CG  1 
ATOM   1452 C CD  . PRO A 1 194 ? -24.64926 22.04610 -2.98635  1.000 29.04690  ? 194 PRO A CD  1 
ATOM   1453 N N   . GLY A 1 195 ? -25.76300 17.53441 -1.92889  1.000 24.37185  ? 195 GLY A N   1 
ATOM   1454 C CA  . GLY A 1 195 ? -25.54849 16.15143 -2.33395  1.000 22.73012  ? 195 GLY A CA  1 
ATOM   1455 C C   . GLY A 1 195 ? -25.74218 15.97927 -3.82154  1.000 28.80512  ? 195 GLY A C   1 
ATOM   1456 O O   . GLY A 1 195 ? -26.64710 16.59671 -4.39080  1.000 27.32391  ? 195 GLY A O   1 
ATOM   1457 N N   . SER A 1 196 ? -24.89450 15.17300 -4.46471  1.000 21.50261  ? 196 SER A N   1 
ATOM   1458 C CA  . SER A 1 196 ? -24.99811 14.88759 -5.90025  1.000 22.83292  ? 196 SER A CA  1 
ATOM   1459 C C   . SER A 1 196 ? -24.70009 16.10428 -6.78207  1.000 29.12857  ? 196 SER A C   1 
ATOM   1460 O O   . SER A 1 196 ? -25.22475 16.21113 -7.89323  1.000 27.96478  ? 196 SER A O   1 
ATOM   1461 C CB  . SER A 1 196 ? -26.38346 14.31183 -6.24689  1.000 28.17388  ? 196 SER A CB  1 
ATOM   1462 O OG  . SER A 1 196 ? -26.49892 13.03575 -5.65749  1.000 32.62795  ? 196 SER A OG  1 
ATOM   1463 N N   . SER A 1 197 ? -23.84734 17.01352 -6.32532  1.000 24.39447  ? 197 SER A N   1 
ATOM   1464 C CA  . SER A 1 197 ? -23.31282 18.04194 -7.20534  1.000 21.25849  ? 197 SER A CA  1 
ATOM   1465 C C   . SER A 1 197 ? -22.36418 17.41811 -8.24351  1.000 18.86309  ? 197 SER A C   1 
ATOM   1466 O O   . SER A 1 197 ? -21.90162 16.29145 -8.10219  1.000 24.17359  ? 197 SER A O   1 
ATOM   1467 C CB  . SER A 1 197 ? -22.58889 19.10741 -6.37313  1.000 22.04098  ? 197 SER A CB  1 
ATOM   1468 O OG  . SER A 1 197 ? -23.49882 19.80491 -5.53262  1.000 25.76846  ? 197 SER A OG  1 
ATOM   1469 N N   . ASN A 1 198 ? -22.04047 18.19372 -9.27588  1.000 21.65378  ? 198 ASN A N   1 
ATOM   1470 C CA  . ASN A 1 198 ? -21.00986 17.80220 -10.23264 1.000 19.47221  ? 198 ASN A CA  1 
ATOM   1471 C C   . ASN A 1 198 ? -19.89660 18.83911 -10.18536 1.000 16.26285  ? 198 ASN A C   1 
ATOM   1472 O O   . ASN A 1 198 ? -20.10675 19.96705 -9.73956  1.000 22.63611  ? 198 ASN A O   1 
ATOM   1473 C CB  . ASN A 1 198 ? -21.56878 17.73547 -11.65487 1.000 22.00854  ? 198 ASN A CB  1 
ATOM   1474 C CG  . ASN A 1 198 ? -22.59455 16.61583 -11.83750 1.000 30.21301  ? 198 ASN A CG  1 
ATOM   1475 O OD1 . ASN A 1 198 ? -22.43436 15.51912 -11.31126 1.000 23.10135  ? 198 ASN A OD1 1 
ATOM   1476 N ND2 . ASN A 1 198 ? -23.66031 16.90375 -12.58877 1.000 31.02370  ? 198 ASN A ND2 1 
ATOM   1477 N N   . TYR A 1 199 ? -18.72410 18.48655 -10.71042 1.000 19.68449  ? 199 TYR A N   1 
ATOM   1478 C CA  . TYR A 1 199 ? -17.51060 19.25808 -10.40366 1.000 18.25451  ? 199 TYR A CA  1 
ATOM   1479 C C   . TYR A 1 199 ? -16.57359 19.29306 -11.59627 1.000 18.92698  ? 199 TYR A C   1 
ATOM   1480 O O   . TYR A 1 199 ? -16.63627 18.44522 -12.48078 1.000 19.59515  ? 199 TYR A O   1 
ATOM   1481 C CB  . TYR A 1 199 ? -16.72208 18.62241 -9.24440  1.000 15.44360  ? 199 TYR A CB  1 
ATOM   1482 C CG  . TYR A 1 199 ? -17.54292 18.53832 -7.98727  1.000 18.74463  ? 199 TYR A CG  1 
ATOM   1483 C CD1 . TYR A 1 199 ? -17.68775 19.65528 -7.16770  1.000 19.16461  ? 199 TYR A CD1 1 
ATOM   1484 C CD2 . TYR A 1 199 ? -18.24167 17.35506 -7.67085  1.000 18.28902  ? 199 TYR A CD2 1 
ATOM   1485 C CE1 . TYR A 1 199 ? -18.46260 19.59429 -6.01286  1.000 20.05359  ? 199 TYR A CE1 1 
ATOM   1486 C CE2 . TYR A 1 199 ? -19.01530 17.29376 -6.50034  1.000 19.77079  ? 199 TYR A CE2 1 
ATOM   1487 C CZ  . TYR A 1 199 ? -19.13359 18.43863 -5.70796  1.000 19.52873  ? 199 TYR A CZ  1 
ATOM   1488 O OH  . TYR A 1 199 ? -19.88546 18.41880 -4.52119  1.000 21.72112  ? 199 TYR A OH  1 
ATOM   1489 N N   . ARG A 1 200 ? -15.66325 20.25963 -11.55736 1.000 18.04953  ? 200 ARG A N   1 
ATOM   1490 C CA  . ARG A 1 200 ? -14.57719 20.38156 -12.52957 1.000 17.47945  ? 200 ARG A CA  1 
ATOM   1491 C C   . ARG A 1 200 ? -13.29668 20.63335 -11.75724 1.000 20.21839  ? 200 ARG A C   1 
ATOM   1492 O O   . ARG A 1 200 ? -13.25966 21.51707 -10.88241 1.000 19.50128  ? 200 ARG A O   1 
ATOM   1493 C CB  . ARG A 1 200 ? -14.79733 21.52887 -13.51652 1.000 15.02191  ? 200 ARG A CB  1 
ATOM   1494 C CG  . ARG A 1 200 ? -13.60804 21.69936 -14.48572 1.000 17.58157  ? 200 ARG A CG  1 
ATOM   1495 C CD  . ARG A 1 200 ? -13.89008 22.83344 -15.47839 1.000 25.65952  ? 200 ARG A CD  1 
ATOM   1496 N NE  . ARG A 1 200 ? -14.95292 22.43188 -16.39206 1.000 23.74483  ? 200 ARG A NE  1 
ATOM   1497 C CZ  . ARG A 1 200 ? -16.10328 23.06255 -16.53784 1.000 32.87973  ? 200 ARG A CZ  1 
ATOM   1498 N NH1 . ARG A 1 200 ? -16.39768 24.13216 -15.80915 1.000 30.31344  ? 200 ARG A NH1 1 
ATOM   1499 N NH2 . ARG A 1 200 ? -16.97328 22.61835 -17.45702 1.000 31.11232  ? 200 ARG A NH2 1 
ATOM   1500 N N   . VAL A 1 201 ? -12.26595 19.86582 -12.07626 1.000 17.27038  ? 201 VAL A N   1 
ATOM   1501 C CA  . VAL A 1 201 ? -10.93022 20.08713 -11.53178 1.000 17.43434  ? 201 VAL A CA  1 
ATOM   1502 C C   . VAL A 1 201 ? -10.09134 20.61967 -12.67474 1.000 15.33134  ? 201 VAL A C   1 
ATOM   1503 O O   . VAL A 1 201 ? -9.93809  19.93360 -13.68796 1.000 17.17802  ? 201 VAL A O   1 
ATOM   1504 C CB  . VAL A 1 201 ? -10.31978 18.79337 -10.97440 1.000 16.57781  ? 201 VAL A CB  1 
ATOM   1505 C CG1 . VAL A 1 201 ? -8.91378  19.06848 -10.44284 1.000 19.48044  ? 201 VAL A CG1 1 
ATOM   1506 C CG2 . VAL A 1 201 ? -11.21341 18.23767 -9.84745  1.000 19.16498  ? 201 VAL A CG2 1 
ATOM   1507 N N   . THR A 1 202 ? -9.53758  21.81096 -12.51069 1.000 16.99001  ? 202 THR A N   1 
ATOM   1508 C CA  . THR A 1 202 ? -8.69825  22.42100 -13.54721 1.000 16.80851  ? 202 THR A CA  1 
ATOM   1509 C C   . THR A 1 202 ? -7.27022  22.51918 -13.01207 1.000 16.74863  ? 202 THR A C   1 
ATOM   1510 O O   . THR A 1 202 ? -7.03872  23.19109 -11.99698 1.000 18.23775  ? 202 THR A O   1 
ATOM   1511 C CB  . THR A 1 202 ? -9.21067  23.81690 -13.91942 1.000 16.69447  ? 202 THR A CB  1 
ATOM   1512 O OG1 . THR A 1 202 ? -10.60368 23.70566 -14.21119 1.000 18.54718  ? 202 THR A OG1 1 
ATOM   1513 C CG2 . THR A 1 202 ? -8.46031  24.39877 -15.13273 1.000 18.88506  ? 202 THR A CG2 1 
ATOM   1514 N N   . PHE A 1 203 ? -6.33361  21.88757 -13.70515 1.000 14.56378  ? 203 PHE A N   1 
ATOM   1515 C CA  . PHE A 1 203 ? -4.91760  22.06607 -13.41747 1.000 16.83963  ? 203 PHE A CA  1 
ATOM   1516 C C   . PHE A 1 203 ? -4.42450  23.31006 -14.12032 1.000 17.87244  ? 203 PHE A C   1 
ATOM   1517 O O   . PHE A 1 203 ? -4.81322  23.55876 -15.26358 1.000 16.89081  ? 203 PHE A O   1 
ATOM   1518 C CB  . PHE A 1 203 ? -4.12231  20.85651 -13.89833 1.000 13.33907  ? 203 PHE A CB  1 
ATOM   1519 C CG  . PHE A 1 203 ? -4.60322  19.55669 -13.32435 1.000 17.77759  ? 203 PHE A CG  1 
ATOM   1520 C CD1 . PHE A 1 203 ? -4.60725  19.34345 -11.96149 1.000 20.21798  ? 203 PHE A CD1 1 
ATOM   1521 C CD2 . PHE A 1 203 ? -5.00504  18.52379 -14.17516 1.000 18.46905  ? 203 PHE A CD2 1 
ATOM   1522 C CE1 . PHE A 1 203 ? -5.02977  18.11215 -11.43388 1.000 19.80750  ? 203 PHE A CE1 1 
ATOM   1523 C CE2 . PHE A 1 203 ? -5.42801  17.30111 -13.65467 1.000 22.31297  ? 203 PHE A CE2 1 
ATOM   1524 C CZ  . PHE A 1 203 ? -5.44102  17.10113 -12.28264 1.000 20.41175  ? 203 PHE A CZ  1 
ATOM   1525 N N   . CYS A 1 204 ? -3.56213  24.08782 -13.43880 1.000 14.87785  ? 204 CYS A N   1 
ATOM   1526 C CA  . CYS A 1 204 ? -3.06684  25.38087 -13.90958 1.000 17.06735  ? 204 CYS A CA  1 
ATOM   1527 C C   . CYS A 1 204 ? -4.19025  26.34529 -14.31670 1.000 20.13066  ? 204 CYS A C   1 
ATOM   1528 O O   . CYS A 1 204 ? -4.22655  26.81709 -15.45515 1.000 18.43339  ? 204 CYS A O   1 
ATOM   1529 C CB  . CYS A 1 204 ? -2.06564  25.23488 -15.04696 1.000 19.39630  ? 204 CYS A CB  1 
ATOM   1530 S SG  . CYS A 1 204 ? -0.66462  24.18611 -14.66160 1.000 19.16953  ? 204 CYS A SG  1 
ATOM   1531 N N   . PRO A 1 205 ? -5.09730  26.65128 -13.38604 1.000 19.31133  ? 205 PRO A N   1 
ATOM   1532 C CA  . PRO A 1 205 ? -6.27544  27.43175 -13.72295 1.000 19.35159  ? 205 PRO A CA  1 
ATOM   1533 C C   . PRO A 1 205 ? -5.95787  28.82184 -14.19687 1.000 22.62883  ? 205 PRO A C   1 
ATOM   1534 O O   . PRO A 1 205 ? -6.78324  29.40968 -14.89834 1.000 25.02585  ? 205 PRO A O   1 
ATOM   1535 C CB  . PRO A 1 205 ? -7.06529  27.47465 -12.40378 1.000 21.57714  ? 205 PRO A CB  1 
ATOM   1536 C CG  . PRO A 1 205 ? -6.03886  27.32245 -11.34325 1.000 18.83602  ? 205 PRO A CG  1 
ATOM   1537 C CD  . PRO A 1 205 ? -5.05779  26.31550 -11.94589 1.000 18.86632  ? 205 PRO A CD  1 
ATOM   1538 N N   . THR A 1 206 ? -4.81085  29.35193 -13.82872 1.000 21.13259  ? 206 THR A N   1 
ATOM   1539 C CA  . THR A 1 206 ? -4.39895  30.70328 -14.18737 1.000 31.74721  ? 206 THR A CA  1 
ATOM   1540 C C   . THR A 1 206 ? -3.44098  30.66321 -15.37092 1.000 40.56946  ? 206 THR A C   1 
ATOM   1541 O O   . THR A 1 206 ? -3.61090  31.40908 -16.32183 1.000 59.54507  ? 206 THR A O   1 
ATOM   1542 C CB  . THR A 1 206 ? -3.71304  31.36838 -12.98260 1.000 37.97637  ? 206 THR A CB  1 
ATOM   1543 O OG1 . THR A 1 206 ? -4.71382  31.62455 -11.99881 1.000 44.21697  ? 206 THR A OG1 1 
ATOM   1544 C CG2 . THR A 1 206 ? -3.03034  32.64617 -13.39450 1.000 61.74305  ? 206 THR A CG2 1 
HETATM 1545 O O1  . TLA B 2 .   ? -10.76891 12.24286 -24.44352 1.000 29.77099  ? 301 TLA A O1  1 
HETATM 1546 O O11 . TLA B 2 .   ? -10.55962 12.48884 -26.61208 1.000 27.41105  ? 301 TLA A O11 1 
HETATM 1547 C C1  . TLA B 2 .   ? -10.42548 12.86739 -25.43688 1.000 30.00885  ? 301 TLA A C1  1 
HETATM 1548 C C2  . TLA B 2 .   ? -9.74140  14.26634 -25.25799 1.000 24.93827  ? 301 TLA A C2  1 
HETATM 1549 O O2  . TLA B 2 .   ? -9.38219  14.56099 -23.89741 1.000 19.56177  ? 301 TLA A O2  1 
HETATM 1550 C C3  . TLA B 2 .   ? -10.65841 15.34714 -25.79762 1.000 17.21049  ? 301 TLA A C3  1 
HETATM 1551 O O3  . TLA B 2 .   ? -11.84491 15.34071 -25.05837 1.000 21.21270  ? 301 TLA A O3  1 
HETATM 1552 C C4  . TLA B 2 .   ? -9.97458  16.72274 -25.60697 1.000 16.09070  ? 301 TLA A C4  1 
HETATM 1553 O O4  . TLA B 2 .   ? -9.00711  16.93410 -26.38362 1.000 20.46423  ? 301 TLA A O4  1 
HETATM 1554 O O41 . TLA B 2 .   ? -10.45554 17.42315 -24.68540 1.000 20.34841  ? 301 TLA A O41 1 
HETATM 1555 O O   . HOH C 3 .   ? 11.69291  24.72547 -6.35611  1.000 55.67243  ? 401 HOH A O   1 
HETATM 1556 O O   . HOH C 3 .   ? -13.00530 27.18653 2.04574   1.000 50.74321  ? 402 HOH A O   1 
HETATM 1557 O O   . HOH C 3 .   ? -10.02044 29.56798 -3.04769  1.000 29.26160  ? 403 HOH A O   1 
HETATM 1558 O O   . HOH C 3 .   ? -4.39569  26.32569 13.13542  1.000 44.82705  ? 404 HOH A O   1 
HETATM 1559 O O   . HOH C 3 .   ? -0.38619  29.86731 -11.09423 1.000 48.77634  ? 405 HOH A O   1 
HETATM 1560 O O   . HOH C 3 .   ? 8.12791   16.69485 -12.41113 1.000 34.44054  ? 406 HOH A O   1 
HETATM 1561 O O   . HOH C 3 .   ? 1.52418   14.90964 17.02883  1.000 31.46324  ? 407 HOH A O   1 
HETATM 1562 O O   . HOH C 3 .   ? -21.79982 14.46600 -5.98693  1.000 22.97959  ? 408 HOH A O   1 
HETATM 1563 O O   . HOH C 3 .   ? -10.12014 23.69473 0.62004   1.000 20.81728  ? 409 HOH A O   1 
HETATM 1564 O O   . HOH C 3 .   ? -21.655   16.967   -15.939   1.000 56.26785  ? 410 HOH A O   1 
HETATM 1565 O O   . HOH C 3 .   ? 11.52041  27.82278 6.29213   1.000 44.51892  ? 411 HOH A O   1 
HETATM 1566 O O   . HOH C 3 .   ? -20.68168 6.72621  1.91293   1.000 48.72178  ? 412 HOH A O   1 
HETATM 1567 O O   . HOH C 3 .   ? 0.08106   12.46550 9.08994   1.000 39.16479  ? 413 HOH A O   1 
HETATM 1568 O O   . HOH C 3 .   ? 6.34434   31.70834 9.53727   1.000 47.95580  ? 414 HOH A O   1 
HETATM 1569 O O   . HOH C 3 .   ? -7.99775  27.50570 7.37082   1.000 32.24528  ? 415 HOH A O   1 
HETATM 1570 O O   . HOH C 3 .   ? -24.70598 8.01308  0.81002   1.000 40.78138  ? 416 HOH A O   1 
HETATM 1571 O O   . HOH C 3 .   ? -16.839   20.495   -21.439   1.000 24.54722  ? 417 HOH A O   1 
HETATM 1572 O O   . HOH C 3 .   ? 3.53857   12.21740 4.03805   1.000 39.44646  ? 418 HOH A O   1 
HETATM 1573 O O   . HOH C 3 .   ? -4.96684  15.71550 2.76658   1.000 25.23842  ? 419 HOH A O   1 
HETATM 1574 O O   . HOH C 3 .   ? -12.21029 23.97862 -11.94039 1.000 20.41747  ? 420 HOH A O   1 
HETATM 1575 O O   . HOH C 3 .   ? 4.67840   11.11120 2.95605   1.000 48.33445  ? 421 HOH A O   1 
HETATM 1576 O O   . HOH C 3 .   ? -17.92887 22.83489 5.20092   1.000 47.13738  ? 422 HOH A O   1 
HETATM 1577 O O   . HOH C 3 .   ? -3.96321  27.73698 10.23255  1.000 39.60253  ? 423 HOH A O   1 
HETATM 1578 O O   . HOH C 3 .   ? -25.25199 21.25231 -6.94056  1.000 35.54648  ? 424 HOH A O   1 
HETATM 1579 O O   . HOH C 3 .   ? 2.80949   24.93217 -13.15896 1.000 36.16088  ? 425 HOH A O   1 
HETATM 1580 O O   . HOH C 3 .   ? -10.66492 20.00253 -23.80136 1.000 16.15945  ? 426 HOH A O   1 
HETATM 1581 O O   . HOH C 3 .   ? -23.23732 15.48310 6.29298   1.000 40.05258  ? 427 HOH A O   1 
HETATM 1582 O O   . HOH C 3 .   ? 13.99239  25.45110 7.08632   1.000 44.56613  ? 428 HOH A O   1 
HETATM 1583 O O   . HOH C 3 .   ? -15.77741 4.70839  -10.56615 1.000 55.15888  ? 429 HOH A O   1 
HETATM 1584 O O   . HOH C 3 .   ? -7.352    15.544   -27.986   1.000 22.53754  ? 430 HOH A O   1 
HETATM 1585 O O   . HOH C 3 .   ? 1.75602   20.95981 4.29632   1.000 21.11295  ? 431 HOH A O   1 
HETATM 1586 O O   . HOH C 3 .   ? -7.56838  16.90315 4.26270   1.000 49.41533  ? 432 HOH A O   1 
HETATM 1587 O O   . HOH C 3 .   ? 1.62634   17.89525 6.04935   1.000 33.40885  ? 433 HOH A O   1 
HETATM 1588 O O   . HOH C 3 .   ? -7.52983  24.55201 5.90637   1.000 38.62411  ? 434 HOH A O   1 
HETATM 1589 O O   . HOH C 3 .   ? -3.95159  12.20868 -24.22953 1.000 29.53514  ? 435 HOH A O   1 
HETATM 1590 O O   . HOH C 3 .   ? -20.48797 4.36542  -3.20392  1.000 45.07180  ? 436 HOH A O   1 
HETATM 1591 O O   . HOH C 3 .   ? -0.82757  11.88285 -2.47338  1.000 25.79235  ? 437 HOH A O   1 
HETATM 1592 O O   . HOH C 3 .   ? -6.91376  5.30633  -18.95813 1.000 31.78089  ? 438 HOH A O   1 
HETATM 1593 O O   . HOH C 3 .   ? -22.93029 11.81158 -6.08780  1.000 24.57292  ? 439 HOH A O   1 
HETATM 1594 O O   . HOH C 3 .   ? 16.24261  21.12346 9.35321   1.000 30.54440  ? 440 HOH A O   1 
HETATM 1595 O O   . HOH C 3 .   ? -5.08546  19.76322 -26.69413 1.000 20.31002  ? 441 HOH A O   1 
HETATM 1596 O O   . HOH C 3 .   ? -1.44886  17.53019 -0.62933  1.000 16.79439  ? 442 HOH A O   1 
HETATM 1597 O O   . HOH C 3 .   ? 5.04147   16.62513 18.73170  1.000 25.91906  ? 443 HOH A O   1 
HETATM 1598 O O   . HOH C 3 .   ? -16.97533 5.40693  -8.29452  1.000 39.55480  ? 444 HOH A O   1 
HETATM 1599 O O   . HOH C 3 .   ? 4.77843   16.48228 -17.06198 1.000 22.16969  ? 445 HOH A O   1 
HETATM 1600 O O   . HOH C 3 .   ? 3.26148   27.08252 16.18107  1.000 23.79053  ? 446 HOH A O   1 
HETATM 1601 O O   . HOH C 3 .   ? -14.34240 8.29424  -18.45614 1.000 48.32951  ? 447 HOH A O   1 
HETATM 1602 O O   . HOH C 3 .   ? -24.07479 11.47705 -8.33972  1.000 35.44498  ? 448 HOH A O   1 
HETATM 1603 O O   . HOH C 3 .   ? 2.49291   20.76170 -24.31707 1.000 43.54432  ? 449 HOH A O   1 
HETATM 1604 O O   . HOH C 3 .   ? -5.83928  29.36308 -1.62720  1.000 20.70054  ? 450 HOH A O   1 
HETATM 1605 O O   . HOH C 3 .   ? -14.96753 24.47877 6.43644   1.000 41.69267  ? 451 HOH A O   1 
HETATM 1606 O O   . HOH C 3 .   ? -1.87684  17.31043 -8.22910  1.000 16.16703  ? 452 HOH A O   1 
HETATM 1607 O O   . HOH C 3 .   ? 5.53061   9.94013  -21.54798 1.000 43.66331  ? 453 HOH A O   1 
HETATM 1608 O O   . HOH C 3 .   ? -12.03667 5.60805  0.62922   1.000 40.80226  ? 454 HOH A O   1 
HETATM 1609 O O   . HOH C 3 .   ? -3.36281  23.08900 15.79645  1.000 34.33441  ? 455 HOH A O   1 
HETATM 1610 O O   . HOH C 3 .   ? 1.73549   27.38305 -9.50850  1.000 42.04483  ? 456 HOH A O   1 
HETATM 1611 O O   . HOH C 3 .   ? 3.46088   21.17200 9.90215   1.000 19.84569  ? 457 HOH A O   1 
HETATM 1612 O O   . HOH C 3 .   ? 12.94030  28.67465 -7.18459  1.000 48.17863  ? 458 HOH A O   1 
HETATM 1613 O O   . HOH C 3 .   ? -0.23259  26.55038 8.90096   1.000 18.07345  ? 459 HOH A O   1 
HETATM 1614 O O   . HOH C 3 .   ? -8.28822  19.83091 10.42553  1.000 33.68371  ? 460 HOH A O   1 
HETATM 1615 O O   . HOH C 3 .   ? -26.88330 10.85820 -7.33402  1.000 52.60413  ? 461 HOH A O   1 
HETATM 1616 O O   . HOH C 3 .   ? -13.39782 21.42975 -20.75497 1.000 17.83284  ? 462 HOH A O   1 
HETATM 1617 O O   . HOH C 3 .   ? -2.04150  35.05013 2.47119   1.000 45.93963  ? 463 HOH A O   1 
HETATM 1618 O O   . HOH C 3 .   ? 4.28353   26.39633 -8.68022  1.000 24.15519  ? 464 HOH A O   1 
HETATM 1619 O O   . HOH C 3 .   ? -4.74798  30.52599 -5.21933  1.000 31.10884  ? 465 HOH A O   1 
HETATM 1620 O O   . HOH C 3 .   ? 0.25377   18.17840 10.51233  1.000 35.89525  ? 466 HOH A O   1 
HETATM 1621 O O   . HOH C 3 .   ? -24.58469 14.35501 -9.93532  1.000 34.35580  ? 467 HOH A O   1 
HETATM 1622 O O   . HOH C 3 .   ? -14.656   16.301   -21.379   1.000 41.46548  ? 468 HOH A O   1 
HETATM 1623 O O   . HOH C 3 .   ? -2.05373  2.18970  -8.16253  1.000 28.72886  ? 469 HOH A O   1 
HETATM 1624 O O   . HOH C 3 .   ? 12.66101  28.43647 -3.82771  1.000 34.72310  ? 470 HOH A O   1 
HETATM 1625 O O   . HOH C 3 .   ? 0.83767   18.67028 -23.82098 1.000 28.29724  ? 471 HOH A O   1 
HETATM 1626 O O   . HOH C 3 .   ? 8.70697   13.20155 -2.01455  1.000 33.43999  ? 472 HOH A O   1 
HETATM 1627 O O   . HOH C 3 .   ? 4.99144   32.07420 5.66129   1.000 33.46906  ? 473 HOH A O   1 
HETATM 1628 O O   . HOH C 3 .   ? 7.25653   11.88117 -5.94134  1.000 25.52653  ? 474 HOH A O   1 
HETATM 1629 O O   . HOH C 3 .   ? 4.06321   4.80434  -5.50838  1.000 40.63166  ? 475 HOH A O   1 
HETATM 1630 O O   . HOH C 3 .   ? 9.50843   14.67684 -6.97169  1.000 33.19387  ? 476 HOH A O   1 
HETATM 1631 O O   . HOH C 3 .   ? -11.70504 26.13508 -15.14739 1.000 43.29214  ? 477 HOH A O   1 
HETATM 1632 O O   . HOH C 3 .   ? 10.05583  30.18273 1.18653   1.000 35.09069  ? 478 HOH A O   1 
HETATM 1633 O O   . HOH C 3 .   ? 4.32933   23.30847 15.99088  1.000 20.31747  ? 479 HOH A O   1 
HETATM 1634 O O   . HOH C 3 .   ? 7.21279   12.49128 -19.66877 1.000 35.32190  ? 480 HOH A O   1 
HETATM 1635 O O   . HOH C 3 .   ? -10.47551 12.46324 0.24438   1.000 25.11118  ? 481 HOH A O   1 
HETATM 1636 O O   . HOH C 3 .   ? -24.15363 28.71428 -6.37871  1.000 55.70813  ? 482 HOH A O   1 
HETATM 1637 O O   . HOH C 3 .   ? -2.56400  28.26149 -17.27274 1.000 40.77370  ? 483 HOH A O   1 
HETATM 1638 O O   . HOH C 3 .   ? 0.59692   8.52276  -0.55900  1.000 37.59102  ? 484 HOH A O   1 
HETATM 1639 O O   . HOH C 3 .   ? -3.77489  31.78310 -3.42498  1.000 51.26830  ? 485 HOH A O   1 
HETATM 1640 O O   . HOH C 3 .   ? 1.87459   6.23594  -11.46583 1.000 20.39879  ? 486 HOH A O   1 
HETATM 1641 O O   . HOH C 3 .   ? 6.87594   0.33493  -12.86234 1.000 41.71962  ? 487 HOH A O   1 
HETATM 1642 O O   . HOH C 3 .   ? -16.94077 4.38077  -4.53753  1.000 54.40095  ? 488 HOH A O   1 
HETATM 1643 O O   . HOH C 3 .   ? 6.81355   30.35613 7.15887   1.000 26.20533  ? 489 HOH A O   1 
HETATM 1644 O O   . HOH C 3 .   ? -2.28555  25.59769 2.27617   1.000 18.90044  ? 490 HOH A O   1 
HETATM 1645 O O   . HOH C 3 .   ? -1.05704  7.67523  15.29711  1.000 45.49873  ? 491 HOH A O   1 
HETATM 1646 O O   . HOH C 3 .   ? 13.821    14.397   11.315    1.000 40.85502  ? 492 HOH A O   1 
HETATM 1647 O O   . HOH C 3 .   ? -2.96264  10.67266 -4.00539  1.000 28.37132  ? 493 HOH A O   1 
HETATM 1648 O O   . HOH C 3 .   ? -13.42998 14.00344 -23.05466 1.000 55.69938  ? 494 HOH A O   1 
HETATM 1649 O O   . HOH C 3 .   ? -17.34212 25.77102 -12.43834 1.000 43.96801  ? 495 HOH A O   1 
HETATM 1650 O O   . HOH C 3 .   ? -9.71874  -0.50297 -8.80660  1.000 35.92170  ? 496 HOH A O   1 
HETATM 1651 O O   . HOH C 3 .   ? -16.62269 5.06672  -0.53667  1.000 38.31522  ? 497 HOH A O   1 
HETATM 1652 O O   . HOH C 3 .   ? 1.92575   20.21111 12.12520  1.000 17.78512  ? 498 HOH A O   1 
HETATM 1653 O O   . HOH C 3 .   ? 2.46397   33.04041 -6.41151  1.000 36.09268  ? 499 HOH A O   1 
HETATM 1654 O O   . HOH C 3 .   ? 1.94634   14.27649 5.02788   1.000 31.45284  ? 500 HOH A O   1 
HETATM 1655 O O   . HOH C 3 .   ? -12.62535 28.96089 -7.44506  1.000 46.11978  ? 501 HOH A O   1 
HETATM 1656 O O   . HOH C 3 .   ? 15.82930  18.45319 3.03670   1.000 42.68428  ? 502 HOH A O   1 
HETATM 1657 O O   . HOH C 3 .   ? 12.79445  17.85102 0.30481   1.000 30.42337  ? 503 HOH A O   1 
HETATM 1658 O O   . HOH C 3 .   ? -19.00266 18.23882 -14.14979 1.000 29.76402  ? 504 HOH A O   1 
HETATM 1659 O O   . HOH C 3 .   ? 4.35802   21.15394 5.63633   1.000 20.92532  ? 505 HOH A O   1 
HETATM 1660 O O   . HOH C 3 .   ? -3.50506  4.19851  -1.16576  1.000 29.74816  ? 506 HOH A O   1 
HETATM 1661 O O   . HOH C 3 .   ? 0.73337   31.63734 7.14325   1.000 31.96115  ? 507 HOH A O   1 
HETATM 1662 O O   . HOH C 3 .   ? -3.71075  7.79940  -21.26961 1.000 24.46164  ? 508 HOH A O   1 
HETATM 1663 O O   . HOH C 3 .   ? 11.80385  16.31091 -15.34428 1.000 43.25373  ? 509 HOH A O   1 
HETATM 1664 O O   . HOH C 3 .   ? 5.782     34.910   -1.646    1.000 52.44975  ? 510 HOH A O   1 
HETATM 1665 O O   . HOH C 3 .   ? 3.37636   19.05586 8.05307   1.000 34.73343  ? 511 HOH A O   1 
HETATM 1666 O O   . HOH C 3 .   ? 0.30919   17.29843 8.54968   1.000 39.51444  ? 512 HOH A O   1 
HETATM 1667 O O   . HOH C 3 .   ? -0.62961  33.82142 -2.65207  1.000 42.35582  ? 513 HOH A O   1 
HETATM 1668 O O   . HOH C 3 .   ? -26.729   11.089   1.404     1.000 24.90706  ? 514 HOH A O   1 
HETATM 1669 O O   . HOH C 3 .   ? 1.52628   25.85184 -17.38355 1.000 27.86590  ? 515 HOH A O   1 
HETATM 1670 O O   . HOH C 3 .   ? -13.65050 16.53899 1.68265   1.000 33.24291  ? 516 HOH A O   1 
HETATM 1671 O O   . HOH C 3 .   ? 1.15753   7.79800  -21.26990 1.000 36.35121  ? 517 HOH A O   1 
HETATM 1672 O O   . HOH C 3 .   ? -12.72539 13.55573 1.76808   1.000 39.75669  ? 518 HOH A O   1 
HETATM 1673 O O   . HOH C 3 .   ? -27.33734 12.71047 -1.25313  1.000 35.99850  ? 519 HOH A O   1 
HETATM 1674 O O   . HOH C 3 .   ? -19.46423 25.49264 2.95752   1.000 40.81793  ? 520 HOH A O   1 
HETATM 1675 O O   . HOH C 3 .   ? 9.77884   10.41135 14.63625  1.000 29.08506  ? 521 HOH A O   1 
HETATM 1676 O O   . HOH C 3 .   ? 6.26552   10.17500 -7.90631  1.000 20.99881  ? 522 HOH A O   1 
HETATM 1677 O O   . HOH C 3 .   ? -2.18814  0.89258  -15.51951 1.000 32.08133  ? 523 HOH A O   1 
HETATM 1678 O O   . HOH C 3 .   ? 2.41615   20.51400 7.38437   1.000 37.13078  ? 524 HOH A O   1 
HETATM 1679 O O   . HOH C 3 .   ? -13.373   13.455   -26.801   1.000 46.89712  ? 525 HOH A O   1 
HETATM 1680 O O   . HOH C 3 .   ? -10.97346 9.10800  -21.84504 1.000 41.60448  ? 526 HOH A O   1 
HETATM 1681 O O   . HOH C 3 .   ? -12.32343 7.06973  -18.77064 1.000 46.78794  ? 527 HOH A O   1 
HETATM 1682 O O   . HOH C 3 .   ? 15.80804  19.63964 -0.91633  1.000 49.89610  ? 528 HOH A O   1 
HETATM 1683 O O   . HOH C 3 .   ? -2.96561  32.63616 5.15270   1.000 43.32151  ? 529 HOH A O   1 
HETATM 1684 O O   . HOH C 3 .   ? 11.28732  21.48226 -6.95564  1.000 35.43662  ? 530 HOH A O   1 
HETATM 1685 O O   . HOH C 3 .   ? -13.80952 12.04957 -21.39266 1.000 37.19403  ? 531 HOH A O   1 
HETATM 1686 O O   . HOH C 3 .   ? 14.57089  25.54371 4.08481   1.000 32.37160  ? 532 HOH A O   1 
HETATM 1687 O O   . HOH C 3 .   ? 4.19105   23.86710 -10.57283 1.000 34.97502  ? 533 HOH A O   1 
HETATM 1688 O O   . HOH C 3 .   ? -29.27265 12.89858 -4.45675  1.000 53.27405  ? 534 HOH A O   1 
HETATM 1689 O O   . HOH C 3 .   ? -2.25016  28.26859 -12.61187 1.000 30.96554  ? 535 HOH A O   1 
HETATM 1690 O O   . HOH C 3 .   ? -3.93998  12.90423 13.32219  1.000 50.10588  ? 536 HOH A O   1 
HETATM 1691 O O   . HOH C 3 .   ? 7.12627   3.17256  -10.31160 1.000 40.59988  ? 537 HOH A O   1 
HETATM 1692 O O   . HOH C 3 .   ? 4.93070   17.92905 -21.59145 1.000 31.71052  ? 538 HOH A O   1 
HETATM 1693 O O   . HOH C 3 .   ? -3.63307  29.90649 -19.05605 1.000 50.41587  ? 539 HOH A O   1 
HETATM 1694 O O   . HOH C 3 .   ? -12.65658 0.44535  -9.45392  1.000 54.27493  ? 540 HOH A O   1 
HETATM 1695 O O   . HOH C 3 .   ? 14.565    28.796   1.401     1.000 45.58301  ? 541 HOH A O   1 
HETATM 1696 O O   . HOH C 3 .   ? -20.12033 27.71242 -0.50307  1.000 39.37585  ? 542 HOH A O   1 
HETATM 1697 O O   . HOH C 3 .   ? 2.55903   5.34793  -4.14813  1.000 52.05822  ? 543 HOH A O   1 
HETATM 1698 O O   . HOH C 3 .   ? 2.91325   15.63095 20.50791  1.000 51.75400  ? 544 HOH A O   1 
HETATM 1699 O O   . HOH C 3 .   ? 9.11232   27.57581 5.70554   1.000 34.63123  ? 545 HOH A O   1 
HETATM 1700 O O   . HOH C 3 .   ? -3.83986  17.39383 -27.57443 1.000 26.66417  ? 546 HOH A O   1 
HETATM 1701 O O   . HOH C 3 .   ? 17.35926  19.32261 5.48035   1.000 51.65684  ? 547 HOH A O   1 
HETATM 1702 O O   . HOH C 3 .   ? -14.40953 25.43859 -13.26116 1.000 34.85052  ? 548 HOH A O   1 
HETATM 1703 O O   . HOH C 3 .   ? 6.39348   18.54016 -16.34242 1.000 41.11119  ? 549 HOH A O   1 
HETATM 1704 O O   . HOH C 3 .   ? -0.68570  27.78644 -17.71571 1.000 55.00167  ? 550 HOH A O   1 
HETATM 1705 O O   . HOH C 3 .   ? 6.00830   16.17812 -19.74948 1.000 48.22853  ? 551 HOH A O   1 
HETATM 1706 O O   . HOH C 3 .   ? -4.67717  9.31190  -23.64698 1.000 46.79097  ? 552 HOH A O   1 
HETATM 1707 O O   . HOH C 3 .   ? -9.84594  6.25446  -19.96268 1.000 46.57451  ? 553 HOH A O   1 
HETATM 1708 O O   . HOH C 3 .   ? -5.52807  5.44487  -21.18001 1.000 46.56465  ? 554 HOH A O   1 
HETATM 1709 O O   . HOH C 3 .   ? -1.37208  6.58787  -22.20010 1.000 57.84939  ? 555 HOH A O   1 
HETATM 1710 O O   . HOH C 3 .   ? 0.33816   14.18512 7.28660   1.000 41.33508  ? 556 HOH A O   1 
HETATM 1711 O O   . HOH C 3 .   ? -25.168   3.488    -7.669    1.000 48.15348  ? 557 HOH A O   1 
HETATM 1712 O O   . HOH C 3 .   ? -1.29417  -0.34844 -7.09176  1.000 37.71876  ? 558 HOH A O   1 
HETATM 1713 O O   . HOH C 3 .   ? 5.38019   25.66111 -14.34995 1.000 57.33623  ? 559 HOH A O   1 
HETATM 1714 O O   . HOH C 3 .   ? -2.51372  10.98123 -0.42694  1.000 41.81185  ? 560 HOH A O   1 
HETATM 1715 O O   . HOH C 3 .   ? -1.67810  28.55625 10.10991  1.000 39.99334  ? 561 HOH A O   1 
HETATM 1716 O O   . HOH C 3 .   ? 6.68304   23.83169 -11.35728 1.000 47.30249  ? 562 HOH A O   1 
HETATM 1717 O O   . HOH C 3 .   ? 0.22915   27.82228 -13.85308 1.000 50.37515  ? 563 HOH A O   1 
HETATM 1718 O O   . HOH C 3 .   ? -1.07070  30.95924 8.78232   1.000 41.27201  ? 564 HOH A O   1 
# 
