data_9FS2
# 
_entry.id   9FS2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FS2         pdb_00009fs2 10.2210/pdb9fs2/pdb 
WWPDB D_1292138944 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FS2 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              sramon@ibv.csic.es 
_pdbx_contact_author.name_first         Santiago 
_pdbx_contact_author.name_last          Ramon-Maiques 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9674-8088 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'del Cano-Ochoa, F.' 1 0000-0003-3093-3103 
'Ramon-Maiques, S.'  2 0000-0001-9674-8088 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Mol.Biol. 
_citation.journal_id_ASTM           JMOBAK 
_citation.journal_id_CSD            0070 
_citation.journal_id_ISSN           1089-8638 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            436 
_citation.language                  ? 
_citation.page_first                168832 
_citation.page_last                 168832 
_citation.title                     'Disruption of CAD Oligomerization by Pathogenic Variants.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.jmb.2024.168832 
_citation.pdbx_database_id_PubMed   39447673 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Del Cano-Ochoa, F.'    1 ? 
primary 'Ramadane-Morchadi, L.' 2 ? 
primary 'Eixeres, L.'           3 ? 
primary 'Moreno-Morcillo, M.'   4 ? 
primary 'Fernandez-Leiro, R.'   5 ? 
primary 'Ramon-Maiques, S.'     6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Multifunctional protein CAD'                         39678.430 1   6.3.5.5,3.5.1.2,6.3.4.16,2.1.3.2,3.5.2.3 
S1538A ? ? 
2 non-polymer syn 'ZINC ION'                                            65.409    4   ?                                        ? ? 
? 
3 non-polymer syn N-CARBAMOYL-L-ASPARTATE                               176.127   1   ?                                        ? ? 
? 
4 non-polymer syn '(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID' 158.112   1   ?                                        ? ? 
? 
5 non-polymer syn 'FORMIC ACID'                                         46.025    11  ?                                        ? ? 
? 
6 water       nat water                                                 18.015    504 ?                                        ? ? 
? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;KLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGAAS
ENAGTLGTVAGSAAGL(KCX)LYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHV
ARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEK
CGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFE
GQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGAAS
ENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKE
EILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSR
PPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKV
KGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLP
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                            ZN  
3 N-CARBAMOYL-L-ASPARTATE                               NCD 
4 '(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID' DOR 
5 'FORMIC ACID'                                         FMT 
6 water                                                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   LEU n 
1 3   VAL n 
1 4   ARG n 
1 5   LEU n 
1 6   PRO n 
1 7   GLY n 
1 8   LEU n 
1 9   ILE n 
1 10  ASP n 
1 11  VAL n 
1 12  HIS n 
1 13  VAL n 
1 14  HIS n 
1 15  LEU n 
1 16  ARG n 
1 17  GLU n 
1 18  PRO n 
1 19  GLY n 
1 20  GLY n 
1 21  THR n 
1 22  HIS n 
1 23  LYS n 
1 24  GLU n 
1 25  ASP n 
1 26  PHE n 
1 27  ALA n 
1 28  SER n 
1 29  GLY n 
1 30  THR n 
1 31  ALA n 
1 32  ALA n 
1 33  ALA n 
1 34  LEU n 
1 35  ALA n 
1 36  GLY n 
1 37  GLY n 
1 38  ILE n 
1 39  THR n 
1 40  MET n 
1 41  VAL n 
1 42  CYS n 
1 43  ALA n 
1 44  MET n 
1 45  PRO n 
1 46  ASN n 
1 47  THR n 
1 48  ARG n 
1 49  PRO n 
1 50  PRO n 
1 51  ILE n 
1 52  ILE n 
1 53  ASP n 
1 54  ALA n 
1 55  PRO n 
1 56  ALA n 
1 57  LEU n 
1 58  ALA n 
1 59  LEU n 
1 60  ALA n 
1 61  GLN n 
1 62  LYS n 
1 63  LEU n 
1 64  ALA n 
1 65  GLU n 
1 66  ALA n 
1 67  GLY n 
1 68  ALA n 
1 69  ARG n 
1 70  CYS n 
1 71  ASP n 
1 72  PHE n 
1 73  ALA n 
1 74  LEU n 
1 75  PHE n 
1 76  LEU n 
1 77  GLY n 
1 78  ALA n 
1 79  ALA n 
1 80  SER n 
1 81  GLU n 
1 82  ASN n 
1 83  ALA n 
1 84  GLY n 
1 85  THR n 
1 86  LEU n 
1 87  GLY n 
1 88  THR n 
1 89  VAL n 
1 90  ALA n 
1 91  GLY n 
1 92  SER n 
1 93  ALA n 
1 94  ALA n 
1 95  GLY n 
1 96  LEU n 
1 97  KCX n 
1 98  LEU n 
1 99  TYR n 
1 100 LEU n 
1 101 ASN n 
1 102 GLU n 
1 103 THR n 
1 104 PHE n 
1 105 SER n 
1 106 GLU n 
1 107 LEU n 
1 108 ARG n 
1 109 LEU n 
1 110 ASP n 
1 111 SER n 
1 112 VAL n 
1 113 VAL n 
1 114 GLN n 
1 115 TRP n 
1 116 MET n 
1 117 GLU n 
1 118 HIS n 
1 119 PHE n 
1 120 GLU n 
1 121 THR n 
1 122 TRP n 
1 123 PRO n 
1 124 SER n 
1 125 HIS n 
1 126 LEU n 
1 127 PRO n 
1 128 ILE n 
1 129 VAL n 
1 130 ALA n 
1 131 HIS n 
1 132 ALA n 
1 133 GLU n 
1 134 GLN n 
1 135 GLN n 
1 136 THR n 
1 137 VAL n 
1 138 ALA n 
1 139 ALA n 
1 140 VAL n 
1 141 LEU n 
1 142 MET n 
1 143 VAL n 
1 144 ALA n 
1 145 GLN n 
1 146 LEU n 
1 147 THR n 
1 148 GLN n 
1 149 ARG n 
1 150 SER n 
1 151 VAL n 
1 152 HIS n 
1 153 ILE n 
1 154 CYS n 
1 155 HIS n 
1 156 VAL n 
1 157 ALA n 
1 158 ARG n 
1 159 LYS n 
1 160 GLU n 
1 161 GLU n 
1 162 ILE n 
1 163 LEU n 
1 164 LEU n 
1 165 ILE n 
1 166 LYS n 
1 167 ALA n 
1 168 ALA n 
1 169 LYS n 
1 170 ALA n 
1 171 ARG n 
1 172 GLY n 
1 173 LEU n 
1 174 PRO n 
1 175 VAL n 
1 176 THR n 
1 177 CYS n 
1 178 GLU n 
1 179 VAL n 
1 180 ALA n 
1 181 PRO n 
1 182 HIS n 
1 183 HIS n 
1 184 LEU n 
1 185 PHE n 
1 186 LEU n 
1 187 SER n 
1 188 HIS n 
1 189 ASP n 
1 190 ASP n 
1 191 LEU n 
1 192 GLU n 
1 193 ARG n 
1 194 LEU n 
1 195 GLY n 
1 196 PRO n 
1 197 GLY n 
1 198 LYS n 
1 199 GLY n 
1 200 GLU n 
1 201 VAL n 
1 202 ARG n 
1 203 PRO n 
1 204 GLU n 
1 205 LEU n 
1 206 GLY n 
1 207 SER n 
1 208 ARG n 
1 209 GLN n 
1 210 ASP n 
1 211 VAL n 
1 212 GLU n 
1 213 ALA n 
1 214 LEU n 
1 215 TRP n 
1 216 GLU n 
1 217 ASN n 
1 218 MET n 
1 219 ALA n 
1 220 VAL n 
1 221 ILE n 
1 222 ASP n 
1 223 CYS n 
1 224 PHE n 
1 225 ALA n 
1 226 SER n 
1 227 ASP n 
1 228 HIS n 
1 229 ALA n 
1 230 PRO n 
1 231 HIS n 
1 232 THR n 
1 233 LEU n 
1 234 GLU n 
1 235 GLU n 
1 236 LYS n 
1 237 CYS n 
1 238 GLY n 
1 239 SER n 
1 240 ARG n 
1 241 PRO n 
1 242 PRO n 
1 243 PRO n 
1 244 GLY n 
1 245 PHE n 
1 246 PRO n 
1 247 GLY n 
1 248 LEU n 
1 249 GLU n 
1 250 THR n 
1 251 MET n 
1 252 LEU n 
1 253 PRO n 
1 254 LEU n 
1 255 LEU n 
1 256 LEU n 
1 257 THR n 
1 258 ALA n 
1 259 VAL n 
1 260 SER n 
1 261 GLU n 
1 262 GLY n 
1 263 ARG n 
1 264 LEU n 
1 265 SER n 
1 266 LEU n 
1 267 ASP n 
1 268 ASP n 
1 269 LEU n 
1 270 LEU n 
1 271 GLN n 
1 272 ARG n 
1 273 LEU n 
1 274 HIS n 
1 275 HIS n 
1 276 ASN n 
1 277 PRO n 
1 278 ARG n 
1 279 ARG n 
1 280 ILE n 
1 281 PHE n 
1 282 HIS n 
1 283 LEU n 
1 284 PRO n 
1 285 PRO n 
1 286 GLN n 
1 287 GLU n 
1 288 ASP n 
1 289 THR n 
1 290 TYR n 
1 291 VAL n 
1 292 GLU n 
1 293 VAL n 
1 294 ASP n 
1 295 LEU n 
1 296 GLU n 
1 297 HIS n 
1 298 GLU n 
1 299 TRP n 
1 300 THR n 
1 301 ILE n 
1 302 PRO n 
1 303 SER n 
1 304 HIS n 
1 305 MET n 
1 306 PRO n 
1 307 PHE n 
1 308 SER n 
1 309 LYS n 
1 310 ALA n 
1 311 HIS n 
1 312 TRP n 
1 313 THR n 
1 314 PRO n 
1 315 PHE n 
1 316 GLU n 
1 317 GLY n 
1 318 GLN n 
1 319 LYS n 
1 320 VAL n 
1 321 LYS n 
1 322 GLY n 
1 323 THR n 
1 324 VAL n 
1 325 ARG n 
1 326 ARG n 
1 327 VAL n 
1 328 VAL n 
1 329 LEU n 
1 330 ARG n 
1 331 GLY n 
1 332 GLU n 
1 333 VAL n 
1 334 ALA n 
1 335 TYR n 
1 336 ILE n 
1 337 ASP n 
1 338 GLY n 
1 339 GLN n 
1 340 VAL n 
1 341 LEU n 
1 342 VAL n 
1 343 PRO n 
1 344 PRO n 
1 345 GLY n 
1 346 TYR n 
1 347 GLY n 
1 348 GLN n 
1 349 ASP n 
1 350 VAL n 
1 351 ARG n 
1 352 LYS n 
1 353 TRP n 
1 354 PRO n 
1 355 GLN n 
1 356 GLY n 
1 357 ALA n 
1 358 VAL n 
1 359 PRO n 
1 360 GLN n 
1 361 LEU n 
1 362 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   362 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CAD 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                Embryo 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               Kidney 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK293S-GnTI 
_entity_src_gen.pdbx_host_org_atcc                 CRL-3022 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 Epithelial-like 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pOPIN-M-huDHO-S1538A 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                               ?                    'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                              ?                    'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                            ?                    'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                       ?                    'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                              ?                    'C3 H7 N O2 S'   121.158 
DOR non-polymer         . '(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID' 'DIHYDROOROTIC ACID' 'C5 H6 N2 O4'    158.112 
FMT non-polymer         . 'FORMIC ACID'                                         ?                    'C H2 O2'        46.025  
GLN 'L-peptide linking' y GLUTAMINE                                             ?                    'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                       ?                    'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                               ?                    'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                             ?                    'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                 ?                    'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                            ?                    'C6 H13 N O2'    131.173 
KCX 'L-peptide linking' n 'LYSINE NZ-CARBOXYLIC ACID'                           ?                    'C7 H14 N2 O4'   190.197 
LEU 'L-peptide linking' y LEUCINE                                               ?                    'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                ?                    'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                            ?                    'C5 H11 N O2 S'  149.211 
NCD non-polymer         . N-CARBAMOYL-L-ASPARTATE                               ?                    'C5 H8 N2 O5'    176.127 
PHE 'L-peptide linking' y PHENYLALANINE                                         ?                    'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                               ?                    'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                ?                    'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                             ?                    'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                            ?                    'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                              ?                    'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                ?                    'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                            ?                    'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1460 1460 LYS LYS A . n 
A 1 2   LEU 2   1461 1461 LEU LEU A . n 
A 1 3   VAL 3   1462 1462 VAL VAL A . n 
A 1 4   ARG 4   1463 1463 ARG ARG A . n 
A 1 5   LEU 5   1464 1464 LEU LEU A . n 
A 1 6   PRO 6   1465 1465 PRO PRO A . n 
A 1 7   GLY 7   1466 1466 GLY GLY A . n 
A 1 8   LEU 8   1467 1467 LEU LEU A . n 
A 1 9   ILE 9   1468 1468 ILE ILE A . n 
A 1 10  ASP 10  1469 1469 ASP ASP A . n 
A 1 11  VAL 11  1470 1470 VAL VAL A . n 
A 1 12  HIS 12  1471 1471 HIS HIS A . n 
A 1 13  VAL 13  1472 1472 VAL VAL A . n 
A 1 14  HIS 14  1473 1473 HIS HIS A . n 
A 1 15  LEU 15  1474 1474 LEU LEU A . n 
A 1 16  ARG 16  1475 1475 ARG ARG A . n 
A 1 17  GLU 17  1476 1476 GLU GLU A . n 
A 1 18  PRO 18  1477 1477 PRO PRO A . n 
A 1 19  GLY 19  1478 1478 GLY GLY A . n 
A 1 20  GLY 20  1479 1479 GLY GLY A . n 
A 1 21  THR 21  1480 1480 THR THR A . n 
A 1 22  HIS 22  1481 1481 HIS HIS A . n 
A 1 23  LYS 23  1482 1482 LYS LYS A . n 
A 1 24  GLU 24  1483 1483 GLU GLU A . n 
A 1 25  ASP 25  1484 1484 ASP ASP A . n 
A 1 26  PHE 26  1485 1485 PHE PHE A . n 
A 1 27  ALA 27  1486 1486 ALA ALA A . n 
A 1 28  SER 28  1487 1487 SER SER A . n 
A 1 29  GLY 29  1488 1488 GLY GLY A . n 
A 1 30  THR 30  1489 1489 THR THR A . n 
A 1 31  ALA 31  1490 1490 ALA ALA A . n 
A 1 32  ALA 32  1491 1491 ALA ALA A . n 
A 1 33  ALA 33  1492 1492 ALA ALA A . n 
A 1 34  LEU 34  1493 1493 LEU LEU A . n 
A 1 35  ALA 35  1494 1494 ALA ALA A . n 
A 1 36  GLY 36  1495 1495 GLY GLY A . n 
A 1 37  GLY 37  1496 1496 GLY GLY A . n 
A 1 38  ILE 38  1497 1497 ILE ILE A . n 
A 1 39  THR 39  1498 1498 THR THR A . n 
A 1 40  MET 40  1499 1499 MET MET A . n 
A 1 41  VAL 41  1500 1500 VAL VAL A . n 
A 1 42  CYS 42  1501 1501 CYS CYS A . n 
A 1 43  ALA 43  1502 1502 ALA ALA A . n 
A 1 44  MET 44  1503 1503 MET MET A . n 
A 1 45  PRO 45  1504 1504 PRO PRO A . n 
A 1 46  ASN 46  1505 1505 ASN ASN A . n 
A 1 47  THR 47  1506 1506 THR THR A . n 
A 1 48  ARG 48  1507 1507 ARG ARG A . n 
A 1 49  PRO 49  1508 1508 PRO PRO A . n 
A 1 50  PRO 50  1509 1509 PRO PRO A . n 
A 1 51  ILE 51  1510 1510 ILE ILE A . n 
A 1 52  ILE 52  1511 1511 ILE ILE A . n 
A 1 53  ASP 53  1512 1512 ASP ASP A . n 
A 1 54  ALA 54  1513 1513 ALA ALA A . n 
A 1 55  PRO 55  1514 1514 PRO PRO A . n 
A 1 56  ALA 56  1515 1515 ALA ALA A . n 
A 1 57  LEU 57  1516 1516 LEU LEU A . n 
A 1 58  ALA 58  1517 1517 ALA ALA A . n 
A 1 59  LEU 59  1518 1518 LEU LEU A . n 
A 1 60  ALA 60  1519 1519 ALA ALA A . n 
A 1 61  GLN 61  1520 1520 GLN GLN A . n 
A 1 62  LYS 62  1521 1521 LYS LYS A . n 
A 1 63  LEU 63  1522 1522 LEU LEU A . n 
A 1 64  ALA 64  1523 1523 ALA ALA A . n 
A 1 65  GLU 65  1524 1524 GLU GLU A . n 
A 1 66  ALA 66  1525 1525 ALA ALA A . n 
A 1 67  GLY 67  1526 1526 GLY GLY A . n 
A 1 68  ALA 68  1527 1527 ALA ALA A . n 
A 1 69  ARG 69  1528 1528 ARG ARG A . n 
A 1 70  CYS 70  1529 1529 CYS CYS A . n 
A 1 71  ASP 71  1530 1530 ASP ASP A . n 
A 1 72  PHE 72  1531 1531 PHE PHE A . n 
A 1 73  ALA 73  1532 1532 ALA ALA A . n 
A 1 74  LEU 74  1533 1533 LEU LEU A . n 
A 1 75  PHE 75  1534 1534 PHE PHE A . n 
A 1 76  LEU 76  1535 1535 LEU LEU A . n 
A 1 77  GLY 77  1536 1536 GLY GLY A . n 
A 1 78  ALA 78  1537 1537 ALA ALA A . n 
A 1 79  ALA 79  1538 1538 ALA ALA A . n 
A 1 80  SER 80  1539 1539 SER SER A . n 
A 1 81  GLU 81  1540 1540 GLU GLU A . n 
A 1 82  ASN 82  1541 1541 ASN ASN A . n 
A 1 83  ALA 83  1542 1542 ALA ALA A . n 
A 1 84  GLY 84  1543 1543 GLY GLY A . n 
A 1 85  THR 85  1544 1544 THR THR A . n 
A 1 86  LEU 86  1545 1545 LEU LEU A . n 
A 1 87  GLY 87  1546 1546 GLY GLY A . n 
A 1 88  THR 88  1547 1547 THR THR A . n 
A 1 89  VAL 89  1548 1548 VAL VAL A . n 
A 1 90  ALA 90  1549 1549 ALA ALA A . n 
A 1 91  GLY 91  1550 1550 GLY GLY A . n 
A 1 92  SER 92  1551 1551 SER SER A . n 
A 1 93  ALA 93  1552 1552 ALA ALA A . n 
A 1 94  ALA 94  1553 1553 ALA ALA A . n 
A 1 95  GLY 95  1554 1554 GLY GLY A . n 
A 1 96  LEU 96  1555 1555 LEU LEU A . n 
A 1 97  KCX 97  1556 1556 KCX KCX A . n 
A 1 98  LEU 98  1557 1557 LEU LEU A . n 
A 1 99  TYR 99  1558 1558 TYR TYR A . n 
A 1 100 LEU 100 1559 1559 LEU LEU A . n 
A 1 101 ASN 101 1560 1560 ASN ASN A . n 
A 1 102 GLU 102 1561 1561 GLU GLU A . n 
A 1 103 THR 103 1562 1562 THR THR A . n 
A 1 104 PHE 104 1563 1563 PHE PHE A . n 
A 1 105 SER 105 1564 1564 SER SER A . n 
A 1 106 GLU 106 1565 1565 GLU GLU A . n 
A 1 107 LEU 107 1566 1566 LEU LEU A . n 
A 1 108 ARG 108 1567 1567 ARG ARG A . n 
A 1 109 LEU 109 1568 1568 LEU LEU A . n 
A 1 110 ASP 110 1569 1569 ASP ASP A . n 
A 1 111 SER 111 1570 1570 SER SER A . n 
A 1 112 VAL 112 1571 1571 VAL VAL A . n 
A 1 113 VAL 113 1572 1572 VAL VAL A . n 
A 1 114 GLN 114 1573 1573 GLN GLN A . n 
A 1 115 TRP 115 1574 1574 TRP TRP A . n 
A 1 116 MET 116 1575 1575 MET MET A . n 
A 1 117 GLU 117 1576 1576 GLU GLU A . n 
A 1 118 HIS 118 1577 1577 HIS HIS A . n 
A 1 119 PHE 119 1578 1578 PHE PHE A . n 
A 1 120 GLU 120 1579 1579 GLU GLU A . n 
A 1 121 THR 121 1580 1580 THR THR A . n 
A 1 122 TRP 122 1581 1581 TRP TRP A . n 
A 1 123 PRO 123 1582 1582 PRO PRO A . n 
A 1 124 SER 124 1583 1583 SER SER A . n 
A 1 125 HIS 125 1584 1584 HIS HIS A . n 
A 1 126 LEU 126 1585 1585 LEU LEU A . n 
A 1 127 PRO 127 1586 1586 PRO PRO A . n 
A 1 128 ILE 128 1587 1587 ILE ILE A . n 
A 1 129 VAL 129 1588 1588 VAL VAL A . n 
A 1 130 ALA 130 1589 1589 ALA ALA A . n 
A 1 131 HIS 131 1590 1590 HIS HIS A . n 
A 1 132 ALA 132 1591 1591 ALA ALA A . n 
A 1 133 GLU 133 1592 1592 GLU GLU A . n 
A 1 134 GLN 134 1593 1593 GLN GLN A . n 
A 1 135 GLN 135 1594 1594 GLN GLN A . n 
A 1 136 THR 136 1595 1595 THR THR A . n 
A 1 137 VAL 137 1596 1596 VAL VAL A . n 
A 1 138 ALA 138 1597 1597 ALA ALA A . n 
A 1 139 ALA 139 1598 1598 ALA ALA A . n 
A 1 140 VAL 140 1599 1599 VAL VAL A . n 
A 1 141 LEU 141 1600 1600 LEU LEU A . n 
A 1 142 MET 142 1601 1601 MET MET A . n 
A 1 143 VAL 143 1602 1602 VAL VAL A . n 
A 1 144 ALA 144 1603 1603 ALA ALA A . n 
A 1 145 GLN 145 1604 1604 GLN GLN A . n 
A 1 146 LEU 146 1605 1605 LEU LEU A . n 
A 1 147 THR 147 1606 1606 THR THR A . n 
A 1 148 GLN 148 1607 1607 GLN GLN A . n 
A 1 149 ARG 149 1608 1608 ARG ARG A . n 
A 1 150 SER 150 1609 1609 SER SER A . n 
A 1 151 VAL 151 1610 1610 VAL VAL A . n 
A 1 152 HIS 152 1611 1611 HIS HIS A . n 
A 1 153 ILE 153 1612 1612 ILE ILE A . n 
A 1 154 CYS 154 1613 1613 CYS CYS A . n 
A 1 155 HIS 155 1614 1614 HIS HIS A . n 
A 1 156 VAL 156 1615 1615 VAL VAL A . n 
A 1 157 ALA 157 1616 1616 ALA ALA A . n 
A 1 158 ARG 158 1617 1617 ARG ARG A . n 
A 1 159 LYS 159 1618 1618 LYS LYS A . n 
A 1 160 GLU 160 1619 1619 GLU GLU A . n 
A 1 161 GLU 161 1620 1620 GLU GLU A . n 
A 1 162 ILE 162 1621 1621 ILE ILE A . n 
A 1 163 LEU 163 1622 1622 LEU LEU A . n 
A 1 164 LEU 164 1623 1623 LEU LEU A . n 
A 1 165 ILE 165 1624 1624 ILE ILE A . n 
A 1 166 LYS 166 1625 1625 LYS LYS A . n 
A 1 167 ALA 167 1626 1626 ALA ALA A . n 
A 1 168 ALA 168 1627 1627 ALA ALA A . n 
A 1 169 LYS 169 1628 1628 LYS LYS A . n 
A 1 170 ALA 170 1629 1629 ALA ALA A . n 
A 1 171 ARG 171 1630 1630 ARG ARG A . n 
A 1 172 GLY 172 1631 1631 GLY GLY A . n 
A 1 173 LEU 173 1632 1632 LEU LEU A . n 
A 1 174 PRO 174 1633 1633 PRO PRO A . n 
A 1 175 VAL 175 1634 1634 VAL VAL A . n 
A 1 176 THR 176 1635 1635 THR THR A . n 
A 1 177 CYS 177 1636 1636 CYS CYS A . n 
A 1 178 GLU 178 1637 1637 GLU GLU A . n 
A 1 179 VAL 179 1638 1638 VAL VAL A . n 
A 1 180 ALA 180 1639 1639 ALA ALA A . n 
A 1 181 PRO 181 1640 1640 PRO PRO A . n 
A 1 182 HIS 182 1641 1641 HIS HIS A . n 
A 1 183 HIS 183 1642 1642 HIS HIS A . n 
A 1 184 LEU 184 1643 1643 LEU LEU A . n 
A 1 185 PHE 185 1644 1644 PHE PHE A . n 
A 1 186 LEU 186 1645 1645 LEU LEU A . n 
A 1 187 SER 187 1646 1646 SER SER A . n 
A 1 188 HIS 188 1647 1647 HIS HIS A . n 
A 1 189 ASP 189 1648 1648 ASP ASP A . n 
A 1 190 ASP 190 1649 1649 ASP ASP A . n 
A 1 191 LEU 191 1650 1650 LEU LEU A . n 
A 1 192 GLU 192 1651 1651 GLU GLU A . n 
A 1 193 ARG 193 1652 1652 ARG ARG A . n 
A 1 194 LEU 194 1653 1653 LEU LEU A . n 
A 1 195 GLY 195 1654 1654 GLY GLY A . n 
A 1 196 PRO 196 1655 1655 PRO PRO A . n 
A 1 197 GLY 197 1656 1656 GLY GLY A . n 
A 1 198 LYS 198 1657 1657 LYS LYS A . n 
A 1 199 GLY 199 1658 1658 GLY GLY A . n 
A 1 200 GLU 200 1659 1659 GLU GLU A . n 
A 1 201 VAL 201 1660 1660 VAL VAL A . n 
A 1 202 ARG 202 1661 1661 ARG ARG A . n 
A 1 203 PRO 203 1662 1662 PRO PRO A . n 
A 1 204 GLU 204 1663 1663 GLU GLU A . n 
A 1 205 LEU 205 1664 1664 LEU LEU A . n 
A 1 206 GLY 206 1665 1665 GLY GLY A . n 
A 1 207 SER 207 1666 1666 SER SER A . n 
A 1 208 ARG 208 1667 1667 ARG ARG A . n 
A 1 209 GLN 209 1668 1668 GLN GLN A . n 
A 1 210 ASP 210 1669 1669 ASP ASP A . n 
A 1 211 VAL 211 1670 1670 VAL VAL A . n 
A 1 212 GLU 212 1671 1671 GLU GLU A . n 
A 1 213 ALA 213 1672 1672 ALA ALA A . n 
A 1 214 LEU 214 1673 1673 LEU LEU A . n 
A 1 215 TRP 215 1674 1674 TRP TRP A . n 
A 1 216 GLU 216 1675 1675 GLU GLU A . n 
A 1 217 ASN 217 1676 1676 ASN ASN A . n 
A 1 218 MET 218 1677 1677 MET MET A . n 
A 1 219 ALA 219 1678 1678 ALA ALA A . n 
A 1 220 VAL 220 1679 1679 VAL VAL A . n 
A 1 221 ILE 221 1680 1680 ILE ILE A . n 
A 1 222 ASP 222 1681 1681 ASP ASP A . n 
A 1 223 CYS 223 1682 1682 CYS CYS A . n 
A 1 224 PHE 224 1683 1683 PHE PHE A . n 
A 1 225 ALA 225 1684 1684 ALA ALA A . n 
A 1 226 SER 226 1685 1685 SER SER A . n 
A 1 227 ASP 227 1686 1686 ASP ASP A . n 
A 1 228 HIS 228 1687 1687 HIS HIS A . n 
A 1 229 ALA 229 1688 1688 ALA ALA A . n 
A 1 230 PRO 230 1689 1689 PRO PRO A . n 
A 1 231 HIS 231 1690 1690 HIS HIS A . n 
A 1 232 THR 232 1691 1691 THR THR A . n 
A 1 233 LEU 233 1692 1692 LEU LEU A . n 
A 1 234 GLU 234 1693 1693 GLU GLU A . n 
A 1 235 GLU 235 1694 1694 GLU GLU A . n 
A 1 236 LYS 236 1695 1695 LYS LYS A . n 
A 1 237 CYS 237 1696 1696 CYS CYS A . n 
A 1 238 GLY 238 1697 1697 GLY GLY A . n 
A 1 239 SER 239 1698 1698 SER SER A . n 
A 1 240 ARG 240 1699 1699 ARG ARG A . n 
A 1 241 PRO 241 1700 1700 PRO PRO A . n 
A 1 242 PRO 242 1701 1701 PRO PRO A . n 
A 1 243 PRO 243 1702 1702 PRO PRO A . n 
A 1 244 GLY 244 1703 1703 GLY GLY A . n 
A 1 245 PHE 245 1704 1704 PHE PHE A . n 
A 1 246 PRO 246 1705 1705 PRO PRO A . n 
A 1 247 GLY 247 1706 1706 GLY GLY A . n 
A 1 248 LEU 248 1707 1707 LEU LEU A . n 
A 1 249 GLU 249 1708 1708 GLU GLU A . n 
A 1 250 THR 250 1709 1709 THR THR A . n 
A 1 251 MET 251 1710 1710 MET MET A . n 
A 1 252 LEU 252 1711 1711 LEU LEU A . n 
A 1 253 PRO 253 1712 1712 PRO PRO A . n 
A 1 254 LEU 254 1713 1713 LEU LEU A . n 
A 1 255 LEU 255 1714 1714 LEU LEU A . n 
A 1 256 LEU 256 1715 1715 LEU LEU A . n 
A 1 257 THR 257 1716 1716 THR THR A . n 
A 1 258 ALA 258 1717 1717 ALA ALA A . n 
A 1 259 VAL 259 1718 1718 VAL VAL A . n 
A 1 260 SER 260 1719 1719 SER SER A . n 
A 1 261 GLU 261 1720 1720 GLU GLU A . n 
A 1 262 GLY 262 1721 1721 GLY GLY A . n 
A 1 263 ARG 263 1722 1722 ARG ARG A . n 
A 1 264 LEU 264 1723 1723 LEU LEU A . n 
A 1 265 SER 265 1724 1724 SER SER A . n 
A 1 266 LEU 266 1725 1725 LEU LEU A . n 
A 1 267 ASP 267 1726 1726 ASP ASP A . n 
A 1 268 ASP 268 1727 1727 ASP ASP A . n 
A 1 269 LEU 269 1728 1728 LEU LEU A . n 
A 1 270 LEU 270 1729 1729 LEU LEU A . n 
A 1 271 GLN 271 1730 1730 GLN GLN A . n 
A 1 272 ARG 272 1731 1731 ARG ARG A . n 
A 1 273 LEU 273 1732 1732 LEU LEU A . n 
A 1 274 HIS 274 1733 1733 HIS HIS A . n 
A 1 275 HIS 275 1734 1734 HIS HIS A . n 
A 1 276 ASN 276 1735 1735 ASN ASN A . n 
A 1 277 PRO 277 1736 1736 PRO PRO A . n 
A 1 278 ARG 278 1737 1737 ARG ARG A . n 
A 1 279 ARG 279 1738 1738 ARG ARG A . n 
A 1 280 ILE 280 1739 1739 ILE ILE A . n 
A 1 281 PHE 281 1740 1740 PHE PHE A . n 
A 1 282 HIS 282 1741 1741 HIS HIS A . n 
A 1 283 LEU 283 1742 1742 LEU LEU A . n 
A 1 284 PRO 284 1743 1743 PRO PRO A . n 
A 1 285 PRO 285 1744 1744 PRO PRO A . n 
A 1 286 GLN 286 1745 1745 GLN GLN A . n 
A 1 287 GLU 287 1746 1746 GLU GLU A . n 
A 1 288 ASP 288 1747 1747 ASP ASP A . n 
A 1 289 THR 289 1748 1748 THR THR A . n 
A 1 290 TYR 290 1749 1749 TYR TYR A . n 
A 1 291 VAL 291 1750 1750 VAL VAL A . n 
A 1 292 GLU 292 1751 1751 GLU GLU A . n 
A 1 293 VAL 293 1752 1752 VAL VAL A . n 
A 1 294 ASP 294 1753 1753 ASP ASP A . n 
A 1 295 LEU 295 1754 1754 LEU LEU A . n 
A 1 296 GLU 296 1755 1755 GLU GLU A . n 
A 1 297 HIS 297 1756 1756 HIS HIS A . n 
A 1 298 GLU 298 1757 1757 GLU GLU A . n 
A 1 299 TRP 299 1758 1758 TRP TRP A . n 
A 1 300 THR 300 1759 1759 THR THR A . n 
A 1 301 ILE 301 1760 1760 ILE ILE A . n 
A 1 302 PRO 302 1761 1761 PRO PRO A . n 
A 1 303 SER 303 1762 1762 SER SER A . n 
A 1 304 HIS 304 1763 1763 HIS HIS A . n 
A 1 305 MET 305 1764 1764 MET MET A . n 
A 1 306 PRO 306 1765 1765 PRO PRO A . n 
A 1 307 PHE 307 1766 1766 PHE PHE A . n 
A 1 308 SER 308 1767 1767 SER SER A . n 
A 1 309 LYS 309 1768 1768 LYS LYS A . n 
A 1 310 ALA 310 1769 1769 ALA ALA A . n 
A 1 311 HIS 311 1770 1770 HIS HIS A . n 
A 1 312 TRP 312 1771 1771 TRP TRP A . n 
A 1 313 THR 313 1772 1772 THR THR A . n 
A 1 314 PRO 314 1773 1773 PRO PRO A . n 
A 1 315 PHE 315 1774 1774 PHE PHE A . n 
A 1 316 GLU 316 1775 1775 GLU GLU A . n 
A 1 317 GLY 317 1776 1776 GLY GLY A . n 
A 1 318 GLN 318 1777 1777 GLN GLN A . n 
A 1 319 LYS 319 1778 1778 LYS LYS A . n 
A 1 320 VAL 320 1779 1779 VAL VAL A . n 
A 1 321 LYS 321 1780 1780 LYS LYS A . n 
A 1 322 GLY 322 1781 1781 GLY GLY A . n 
A 1 323 THR 323 1782 1782 THR THR A . n 
A 1 324 VAL 324 1783 1783 VAL VAL A . n 
A 1 325 ARG 325 1784 1784 ARG ARG A . n 
A 1 326 ARG 326 1785 1785 ARG ARG A . n 
A 1 327 VAL 327 1786 1786 VAL VAL A . n 
A 1 328 VAL 328 1787 1787 VAL VAL A . n 
A 1 329 LEU 329 1788 1788 LEU LEU A . n 
A 1 330 ARG 330 1789 1789 ARG ARG A . n 
A 1 331 GLY 331 1790 1790 GLY GLY A . n 
A 1 332 GLU 332 1791 1791 GLU GLU A . n 
A 1 333 VAL 333 1792 1792 VAL VAL A . n 
A 1 334 ALA 334 1793 1793 ALA ALA A . n 
A 1 335 TYR 335 1794 1794 TYR TYR A . n 
A 1 336 ILE 336 1795 1795 ILE ILE A . n 
A 1 337 ASP 337 1796 1796 ASP ASP A . n 
A 1 338 GLY 338 1797 1797 GLY GLY A . n 
A 1 339 GLN 339 1798 1798 GLN GLN A . n 
A 1 340 VAL 340 1799 1799 VAL VAL A . n 
A 1 341 LEU 341 1800 1800 LEU LEU A . n 
A 1 342 VAL 342 1801 1801 VAL VAL A . n 
A 1 343 PRO 343 1802 1802 PRO PRO A . n 
A 1 344 PRO 344 1803 1803 PRO PRO A . n 
A 1 345 GLY 345 1804 1804 GLY GLY A . n 
A 1 346 TYR 346 1805 1805 TYR TYR A . n 
A 1 347 GLY 347 1806 1806 GLY GLY A . n 
A 1 348 GLN 348 1807 1807 GLN GLN A . n 
A 1 349 ASP 349 1808 1808 ASP ASP A . n 
A 1 350 VAL 350 1809 1809 VAL VAL A . n 
A 1 351 ARG 351 1810 1810 ARG ARG A . n 
A 1 352 LYS 352 1811 1811 LYS LYS A . n 
A 1 353 TRP 353 1812 1812 TRP TRP A . n 
A 1 354 PRO 354 1813 1813 PRO PRO A . n 
A 1 355 GLN 355 1814 1814 GLN GLN A . n 
A 1 356 GLY 356 1815 1815 GLY GLY A . n 
A 1 357 ALA 357 1816 1816 ALA ALA A . n 
A 1 358 VAL 358 1817 1817 VAL VAL A . n 
A 1 359 PRO 359 1818 1818 PRO PRO A . n 
A 1 360 GLN 360 1819 1819 GLN GLN A . n 
A 1 361 LEU 361 1820 1820 LEU LEU A . n 
A 1 362 PRO 362 1821 1821 PRO PRO A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 DOR ? ? DOR ? ? 'SUBJECT OF INVESTIGATION' ? 
2 NCD ? ? NCD ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1901 1901 ZN  ZN  A . 
C 2 ZN  1   1902 1902 ZN  ZN  A . 
D 3 NCD 1   1903 1903 NCD NCD A . 
E 2 ZN  1   1904 1904 ZN  ZN  A . 
F 4 DOR 1   1905 1905 DOR DOR A . 
G 5 FMT 1   1906 1909 FMT FMT A . 
H 5 FMT 1   1907 1910 FMT FMT A . 
I 5 FMT 1   1908 1911 FMT FMT A . 
J 5 FMT 1   1909 1912 FMT FMT A . 
K 5 FMT 1   1910 1913 FMT FMT A . 
L 5 FMT 1   1911 1914 FMT FMT A . 
M 5 FMT 1   1912 1915 FMT FMT A . 
N 2 ZN  1   1913 1916 ZN  ZN  A . 
O 5 FMT 1   1914 1917 FMT FMT A . 
P 5 FMT 1   1915 1920 FMT FMT A . 
Q 5 FMT 1   1916 1921 FMT FMT A . 
R 5 FMT 1   1917 492  FMT FMT A . 
S 6 HOH 1   2001 303  HOH HOH A . 
S 6 HOH 2   2002 356  HOH HOH A . 
S 6 HOH 3   2003 69   HOH HOH A . 
S 6 HOH 4   2004 300  HOH HOH A . 
S 6 HOH 5   2005 46   HOH HOH A . 
S 6 HOH 6   2006 415  HOH HOH A . 
S 6 HOH 7   2007 455  HOH HOH A . 
S 6 HOH 8   2008 82   HOH HOH A . 
S 6 HOH 9   2009 220  HOH HOH A . 
S 6 HOH 10  2010 188  HOH HOH A . 
S 6 HOH 11  2011 288  HOH HOH A . 
S 6 HOH 12  2012 395  HOH HOH A . 
S 6 HOH 13  2013 216  HOH HOH A . 
S 6 HOH 14  2014 278  HOH HOH A . 
S 6 HOH 15  2015 373  HOH HOH A . 
S 6 HOH 16  2016 362  HOH HOH A . 
S 6 HOH 17  2017 473  HOH HOH A . 
S 6 HOH 18  2018 267  HOH HOH A . 
S 6 HOH 19  2019 238  HOH HOH A . 
S 6 HOH 20  2020 183  HOH HOH A . 
S 6 HOH 21  2021 412  HOH HOH A . 
S 6 HOH 22  2022 263  HOH HOH A . 
S 6 HOH 23  2023 225  HOH HOH A . 
S 6 HOH 24  2024 59   HOH HOH A . 
S 6 HOH 25  2025 53   HOH HOH A . 
S 6 HOH 26  2026 218  HOH HOH A . 
S 6 HOH 27  2027 126  HOH HOH A . 
S 6 HOH 28  2028 265  HOH HOH A . 
S 6 HOH 29  2029 138  HOH HOH A . 
S 6 HOH 30  2030 408  HOH HOH A . 
S 6 HOH 31  2031 230  HOH HOH A . 
S 6 HOH 32  2032 43   HOH HOH A . 
S 6 HOH 33  2033 21   HOH HOH A . 
S 6 HOH 34  2034 204  HOH HOH A . 
S 6 HOH 35  2035 133  HOH HOH A . 
S 6 HOH 36  2036 9    HOH HOH A . 
S 6 HOH 37  2037 221  HOH HOH A . 
S 6 HOH 38  2038 48   HOH HOH A . 
S 6 HOH 39  2039 78   HOH HOH A . 
S 6 HOH 40  2040 193  HOH HOH A . 
S 6 HOH 41  2041 115  HOH HOH A . 
S 6 HOH 42  2042 276  HOH HOH A . 
S 6 HOH 43  2043 283  HOH HOH A . 
S 6 HOH 44  2044 64   HOH HOH A . 
S 6 HOH 45  2045 72   HOH HOH A . 
S 6 HOH 46  2046 377  HOH HOH A . 
S 6 HOH 47  2047 80   HOH HOH A . 
S 6 HOH 48  2048 130  HOH HOH A . 
S 6 HOH 49  2049 54   HOH HOH A . 
S 6 HOH 50  2050 197  HOH HOH A . 
S 6 HOH 51  2051 261  HOH HOH A . 
S 6 HOH 52  2052 173  HOH HOH A . 
S 6 HOH 53  2053 409  HOH HOH A . 
S 6 HOH 54  2054 266  HOH HOH A . 
S 6 HOH 55  2055 75   HOH HOH A . 
S 6 HOH 56  2056 249  HOH HOH A . 
S 6 HOH 57  2057 84   HOH HOH A . 
S 6 HOH 58  2058 166  HOH HOH A . 
S 6 HOH 59  2059 32   HOH HOH A . 
S 6 HOH 60  2060 31   HOH HOH A . 
S 6 HOH 61  2061 161  HOH HOH A . 
S 6 HOH 62  2062 401  HOH HOH A . 
S 6 HOH 63  2063 385  HOH HOH A . 
S 6 HOH 64  2064 63   HOH HOH A . 
S 6 HOH 65  2065 24   HOH HOH A . 
S 6 HOH 66  2066 198  HOH HOH A . 
S 6 HOH 67  2067 184  HOH HOH A . 
S 6 HOH 68  2068 163  HOH HOH A . 
S 6 HOH 69  2069 156  HOH HOH A . 
S 6 HOH 70  2070 132  HOH HOH A . 
S 6 HOH 71  2071 27   HOH HOH A . 
S 6 HOH 72  2072 65   HOH HOH A . 
S 6 HOH 73  2073 239  HOH HOH A . 
S 6 HOH 74  2074 145  HOH HOH A . 
S 6 HOH 75  2075 254  HOH HOH A . 
S 6 HOH 76  2076 12   HOH HOH A . 
S 6 HOH 77  2077 203  HOH HOH A . 
S 6 HOH 78  2078 10   HOH HOH A . 
S 6 HOH 79  2079 454  HOH HOH A . 
S 6 HOH 80  2080 269  HOH HOH A . 
S 6 HOH 81  2081 397  HOH HOH A . 
S 6 HOH 82  2082 393  HOH HOH A . 
S 6 HOH 83  2083 185  HOH HOH A . 
S 6 HOH 84  2084 117  HOH HOH A . 
S 6 HOH 85  2085 226  HOH HOH A . 
S 6 HOH 86  2086 196  HOH HOH A . 
S 6 HOH 87  2087 168  HOH HOH A . 
S 6 HOH 88  2088 50   HOH HOH A . 
S 6 HOH 89  2089 26   HOH HOH A . 
S 6 HOH 90  2090 187  HOH HOH A . 
S 6 HOH 91  2091 349  HOH HOH A . 
S 6 HOH 92  2092 211  HOH HOH A . 
S 6 HOH 93  2093 105  HOH HOH A . 
S 6 HOH 94  2094 106  HOH HOH A . 
S 6 HOH 95  2095 224  HOH HOH A . 
S 6 HOH 96  2096 237  HOH HOH A . 
S 6 HOH 97  2097 152  HOH HOH A . 
S 6 HOH 98  2098 2    HOH HOH A . 
S 6 HOH 99  2099 444  HOH HOH A . 
S 6 HOH 100 2100 24   HOH HOH A . 
S 6 HOH 101 2101 202  HOH HOH A . 
S 6 HOH 102 2102 46   HOH HOH A . 
S 6 HOH 103 2103 68   HOH HOH A . 
S 6 HOH 104 2104 23   HOH HOH A . 
S 6 HOH 105 2105 253  HOH HOH A . 
S 6 HOH 106 2106 147  HOH HOH A . 
S 6 HOH 107 2107 139  HOH HOH A . 
S 6 HOH 108 2108 47   HOH HOH A . 
S 6 HOH 109 2109 413  HOH HOH A . 
S 6 HOH 110 2110 186  HOH HOH A . 
S 6 HOH 111 2111 112  HOH HOH A . 
S 6 HOH 112 2112 170  HOH HOH A . 
S 6 HOH 113 2113 270  HOH HOH A . 
S 6 HOH 114 2114 42   HOH HOH A . 
S 6 HOH 115 2115 82   HOH HOH A . 
S 6 HOH 116 2116 89   HOH HOH A . 
S 6 HOH 117 2117 100  HOH HOH A . 
S 6 HOH 118 2118 210  HOH HOH A . 
S 6 HOH 119 2119 14   HOH HOH A . 
S 6 HOH 120 2120 219  HOH HOH A . 
S 6 HOH 121 2121 92   HOH HOH A . 
S 6 HOH 122 2122 37   HOH HOH A . 
S 6 HOH 123 2123 118  HOH HOH A . 
S 6 HOH 124 2124 95   HOH HOH A . 
S 6 HOH 125 2125 103  HOH HOH A . 
S 6 HOH 126 2126 55   HOH HOH A . 
S 6 HOH 127 2127 159  HOH HOH A . 
S 6 HOH 128 2128 44   HOH HOH A . 
S 6 HOH 129 2129 22   HOH HOH A . 
S 6 HOH 130 2130 169  HOH HOH A . 
S 6 HOH 131 2131 206  HOH HOH A . 
S 6 HOH 132 2132 71   HOH HOH A . 
S 6 HOH 133 2133 222  HOH HOH A . 
S 6 HOH 134 2134 162  HOH HOH A . 
S 6 HOH 135 2135 79   HOH HOH A . 
S 6 HOH 136 2136 19   HOH HOH A . 
S 6 HOH 137 2137 125  HOH HOH A . 
S 6 HOH 138 2138 462  HOH HOH A . 
S 6 HOH 139 2139 102  HOH HOH A . 
S 6 HOH 140 2140 273  HOH HOH A . 
S 6 HOH 141 2141 427  HOH HOH A . 
S 6 HOH 142 2142 21   HOH HOH A . 
S 6 HOH 143 2143 114  HOH HOH A . 
S 6 HOH 144 2144 18   HOH HOH A . 
S 6 HOH 145 2145 16   HOH HOH A . 
S 6 HOH 146 2146 121  HOH HOH A . 
S 6 HOH 147 2147 122  HOH HOH A . 
S 6 HOH 148 2148 36   HOH HOH A . 
S 6 HOH 149 2149 171  HOH HOH A . 
S 6 HOH 150 2150 461  HOH HOH A . 
S 6 HOH 151 2151 20   HOH HOH A . 
S 6 HOH 152 2152 61   HOH HOH A . 
S 6 HOH 153 2153 77   HOH HOH A . 
S 6 HOH 154 2154 30   HOH HOH A . 
S 6 HOH 155 2155 229  HOH HOH A . 
S 6 HOH 156 2156 120  HOH HOH A . 
S 6 HOH 157 2157 137  HOH HOH A . 
S 6 HOH 158 2158 109  HOH HOH A . 
S 6 HOH 159 2159 180  HOH HOH A . 
S 6 HOH 160 2160 243  HOH HOH A . 
S 6 HOH 161 2161 81   HOH HOH A . 
S 6 HOH 162 2162 69   HOH HOH A . 
S 6 HOH 163 2163 55   HOH HOH A . 
S 6 HOH 164 2164 407  HOH HOH A . 
S 6 HOH 165 2165 420  HOH HOH A . 
S 6 HOH 166 2166 5    HOH HOH A . 
S 6 HOH 167 2167 330  HOH HOH A . 
S 6 HOH 168 2168 45   HOH HOH A . 
S 6 HOH 169 2169 39   HOH HOH A . 
S 6 HOH 170 2170 83   HOH HOH A . 
S 6 HOH 171 2171 111  HOH HOH A . 
S 6 HOH 172 2172 205  HOH HOH A . 
S 6 HOH 173 2173 434  HOH HOH A . 
S 6 HOH 174 2174 245  HOH HOH A . 
S 6 HOH 175 2175 298  HOH HOH A . 
S 6 HOH 176 2176 246  HOH HOH A . 
S 6 HOH 177 2177 248  HOH HOH A . 
S 6 HOH 178 2178 38   HOH HOH A . 
S 6 HOH 179 2179 70   HOH HOH A . 
S 6 HOH 180 2180 15   HOH HOH A . 
S 6 HOH 181 2181 4    HOH HOH A . 
S 6 HOH 182 2182 81   HOH HOH A . 
S 6 HOH 183 2183 40   HOH HOH A . 
S 6 HOH 184 2184 151  HOH HOH A . 
S 6 HOH 185 2185 62   HOH HOH A . 
S 6 HOH 186 2186 86   HOH HOH A . 
S 6 HOH 187 2187 241  HOH HOH A . 
S 6 HOH 188 2188 158  HOH HOH A . 
S 6 HOH 189 2189 411  HOH HOH A . 
S 6 HOH 190 2190 228  HOH HOH A . 
S 6 HOH 191 2191 1    HOH HOH A . 
S 6 HOH 192 2192 451  HOH HOH A . 
S 6 HOH 193 2193 134  HOH HOH A . 
S 6 HOH 194 2194 8    HOH HOH A . 
S 6 HOH 195 2195 35   HOH HOH A . 
S 6 HOH 196 2196 190  HOH HOH A . 
S 6 HOH 197 2197 72   HOH HOH A . 
S 6 HOH 198 2198 60   HOH HOH A . 
S 6 HOH 199 2199 285  HOH HOH A . 
S 6 HOH 200 2200 275  HOH HOH A . 
S 6 HOH 201 2201 155  HOH HOH A . 
S 6 HOH 202 2202 242  HOH HOH A . 
S 6 HOH 203 2203 131  HOH HOH A . 
S 6 HOH 204 2204 200  HOH HOH A . 
S 6 HOH 205 2205 234  HOH HOH A . 
S 6 HOH 206 2206 59   HOH HOH A . 
S 6 HOH 207 2207 486  HOH HOH A . 
S 6 HOH 208 2208 231  HOH HOH A . 
S 6 HOH 209 2209 56   HOH HOH A . 
S 6 HOH 210 2210 181  HOH HOH A . 
S 6 HOH 211 2211 58   HOH HOH A . 
S 6 HOH 212 2212 485  HOH HOH A . 
S 6 HOH 213 2213 41   HOH HOH A . 
S 6 HOH 214 2214 91   HOH HOH A . 
S 6 HOH 215 2215 90   HOH HOH A . 
S 6 HOH 216 2216 7    HOH HOH A . 
S 6 HOH 217 2217 301  HOH HOH A . 
S 6 HOH 218 2218 305  HOH HOH A . 
S 6 HOH 219 2219 57   HOH HOH A . 
S 6 HOH 220 2220 429  HOH HOH A . 
S 6 HOH 221 2221 128  HOH HOH A . 
S 6 HOH 222 2222 215  HOH HOH A . 
S 6 HOH 223 2223 32   HOH HOH A . 
S 6 HOH 224 2224 214  HOH HOH A . 
S 6 HOH 225 2225 17   HOH HOH A . 
S 6 HOH 226 2226 88   HOH HOH A . 
S 6 HOH 227 2227 281  HOH HOH A . 
S 6 HOH 228 2228 97   HOH HOH A . 
S 6 HOH 229 2229 223  HOH HOH A . 
S 6 HOH 230 2230 317  HOH HOH A . 
S 6 HOH 231 2231 182  HOH HOH A . 
S 6 HOH 232 2232 167  HOH HOH A . 
S 6 HOH 233 2233 73   HOH HOH A . 
S 6 HOH 234 2234 489  HOH HOH A . 
S 6 HOH 235 2235 148  HOH HOH A . 
S 6 HOH 236 2236 438  HOH HOH A . 
S 6 HOH 237 2237 312  HOH HOH A . 
S 6 HOH 238 2238 207  HOH HOH A . 
S 6 HOH 239 2239 101  HOH HOH A . 
S 6 HOH 240 2240 66   HOH HOH A . 
S 6 HOH 241 2241 13   HOH HOH A . 
S 6 HOH 242 2242 74   HOH HOH A . 
S 6 HOH 243 2243 6    HOH HOH A . 
S 6 HOH 244 2244 172  HOH HOH A . 
S 6 HOH 245 2245 483  HOH HOH A . 
S 6 HOH 246 2246 3    HOH HOH A . 
S 6 HOH 247 2247 49   HOH HOH A . 
S 6 HOH 248 2248 157  HOH HOH A . 
S 6 HOH 249 2249 94   HOH HOH A . 
S 6 HOH 250 2250 165  HOH HOH A . 
S 6 HOH 251 2251 194  HOH HOH A . 
S 6 HOH 252 2252 491  HOH HOH A . 
S 6 HOH 253 2253 233  HOH HOH A . 
S 6 HOH 254 2254 11   HOH HOH A . 
S 6 HOH 255 2255 87   HOH HOH A . 
S 6 HOH 256 2256 25   HOH HOH A . 
S 6 HOH 257 2257 164  HOH HOH A . 
S 6 HOH 258 2258 78   HOH HOH A . 
S 6 HOH 259 2259 463  HOH HOH A . 
S 6 HOH 260 2260 116  HOH HOH A . 
S 6 HOH 261 2261 25   HOH HOH A . 
S 6 HOH 262 2262 110  HOH HOH A . 
S 6 HOH 263 2263 240  HOH HOH A . 
S 6 HOH 264 2264 191  HOH HOH A . 
S 6 HOH 265 2265 76   HOH HOH A . 
S 6 HOH 266 2266 33   HOH HOH A . 
S 6 HOH 267 2267 104  HOH HOH A . 
S 6 HOH 268 2268 189  HOH HOH A . 
S 6 HOH 269 2269 14   HOH HOH A . 
S 6 HOH 270 2270 201  HOH HOH A . 
S 6 HOH 271 2271 119  HOH HOH A . 
S 6 HOH 272 2272 66   HOH HOH A . 
S 6 HOH 273 2273 456  HOH HOH A . 
S 6 HOH 274 2274 52   HOH HOH A . 
S 6 HOH 275 2275 143  HOH HOH A . 
S 6 HOH 276 2276 141  HOH HOH A . 
S 6 HOH 277 2277 370  HOH HOH A . 
S 6 HOH 278 2278 212  HOH HOH A . 
S 6 HOH 279 2279 127  HOH HOH A . 
S 6 HOH 280 2280 150  HOH HOH A . 
S 6 HOH 281 2281 51   HOH HOH A . 
S 6 HOH 282 2282 13   HOH HOH A . 
S 6 HOH 283 2283 34   HOH HOH A . 
S 6 HOH 284 2284 19   HOH HOH A . 
S 6 HOH 285 2285 217  HOH HOH A . 
S 6 HOH 286 2286 260  HOH HOH A . 
S 6 HOH 287 2287 478  HOH HOH A . 
S 6 HOH 288 2288 192  HOH HOH A . 
S 6 HOH 289 2289 476  HOH HOH A . 
S 6 HOH 290 2290 27   HOH HOH A . 
S 6 HOH 291 2291 178  HOH HOH A . 
S 6 HOH 292 2292 23   HOH HOH A . 
S 6 HOH 293 2293 4    HOH HOH A . 
S 6 HOH 294 2294 30   HOH HOH A . 
S 6 HOH 295 2295 379  HOH HOH A . 
S 6 HOH 296 2296 364  HOH HOH A . 
S 6 HOH 297 2297 280  HOH HOH A . 
S 6 HOH 298 2298 227  HOH HOH A . 
S 6 HOH 299 2299 421  HOH HOH A . 
S 6 HOH 300 2300 124  HOH HOH A . 
S 6 HOH 301 2301 199  HOH HOH A . 
S 6 HOH 302 2302 251  HOH HOH A . 
S 6 HOH 303 2303 29   HOH HOH A . 
S 6 HOH 304 2304 488  HOH HOH A . 
S 6 HOH 305 2305 453  HOH HOH A . 
S 6 HOH 306 2306 17   HOH HOH A . 
S 6 HOH 307 2307 258  HOH HOH A . 
S 6 HOH 308 2308 107  HOH HOH A . 
S 6 HOH 309 2309 6    HOH HOH A . 
S 6 HOH 310 2310 282  HOH HOH A . 
S 6 HOH 311 2311 287  HOH HOH A . 
S 6 HOH 312 2312 146  HOH HOH A . 
S 6 HOH 313 2313 458  HOH HOH A . 
S 6 HOH 314 2314 58   HOH HOH A . 
S 6 HOH 315 2315 28   HOH HOH A . 
S 6 HOH 316 2316 96   HOH HOH A . 
S 6 HOH 317 2317 54   HOH HOH A . 
S 6 HOH 318 2318 257  HOH HOH A . 
S 6 HOH 319 2319 361  HOH HOH A . 
S 6 HOH 320 2320 51   HOH HOH A . 
S 6 HOH 321 2321 460  HOH HOH A . 
S 6 HOH 322 2322 295  HOH HOH A . 
S 6 HOH 323 2323 144  HOH HOH A . 
S 6 HOH 324 2324 417  HOH HOH A . 
S 6 HOH 325 2325 37   HOH HOH A . 
S 6 HOH 326 2326 108  HOH HOH A . 
S 6 HOH 327 2327 314  HOH HOH A . 
S 6 HOH 328 2328 419  HOH HOH A . 
S 6 HOH 329 2329 272  HOH HOH A . 
S 6 HOH 330 2330 36   HOH HOH A . 
S 6 HOH 331 2331 279  HOH HOH A . 
S 6 HOH 332 2332 405  HOH HOH A . 
S 6 HOH 333 2333 447  HOH HOH A . 
S 6 HOH 334 2334 68   HOH HOH A . 
S 6 HOH 335 2335 244  HOH HOH A . 
S 6 HOH 336 2336 345  HOH HOH A . 
S 6 HOH 337 2337 77   HOH HOH A . 
S 6 HOH 338 2338 9    HOH HOH A . 
S 6 HOH 339 2339 402  HOH HOH A . 
S 6 HOH 340 2340 341  HOH HOH A . 
S 6 HOH 341 2341 366  HOH HOH A . 
S 6 HOH 342 2342 321  HOH HOH A . 
S 6 HOH 343 2343 18   HOH HOH A . 
S 6 HOH 344 2344 326  HOH HOH A . 
S 6 HOH 345 2345 16   HOH HOH A . 
S 6 HOH 346 2346 404  HOH HOH A . 
S 6 HOH 347 2347 31   HOH HOH A . 
S 6 HOH 348 2348 175  HOH HOH A . 
S 6 HOH 349 2349 290  HOH HOH A . 
S 6 HOH 350 2350 3    HOH HOH A . 
S 6 HOH 351 2351 286  HOH HOH A . 
S 6 HOH 352 2352 471  HOH HOH A . 
S 6 HOH 353 2353 371  HOH HOH A . 
S 6 HOH 354 2354 79   HOH HOH A . 
S 6 HOH 355 2355 20   HOH HOH A . 
S 6 HOH 356 2356 153  HOH HOH A . 
S 6 HOH 357 2357 177  HOH HOH A . 
S 6 HOH 358 2358 386  HOH HOH A . 
S 6 HOH 359 2359 324  HOH HOH A . 
S 6 HOH 360 2360 327  HOH HOH A . 
S 6 HOH 361 2361 416  HOH HOH A . 
S 6 HOH 362 2362 292  HOH HOH A . 
S 6 HOH 363 2363 135  HOH HOH A . 
S 6 HOH 364 2364 140  HOH HOH A . 
S 6 HOH 365 2365 381  HOH HOH A . 
S 6 HOH 366 2366 445  HOH HOH A . 
S 6 HOH 367 2367 271  HOH HOH A . 
S 6 HOH 368 2368 308  HOH HOH A . 
S 6 HOH 369 2369 333  HOH HOH A . 
S 6 HOH 370 2370 129  HOH HOH A . 
S 6 HOH 371 2371 45   HOH HOH A . 
S 6 HOH 372 2372 98   HOH HOH A . 
S 6 HOH 373 2373 328  HOH HOH A . 
S 6 HOH 374 2374 174  HOH HOH A . 
S 6 HOH 375 2375 250  HOH HOH A . 
S 6 HOH 376 2376 316  HOH HOH A . 
S 6 HOH 377 2377 440  HOH HOH A . 
S 6 HOH 378 2378 338  HOH HOH A . 
S 6 HOH 379 2379 384  HOH HOH A . 
S 6 HOH 380 2380 368  HOH HOH A . 
S 6 HOH 381 2381 7    HOH HOH A . 
S 6 HOH 382 2382 430  HOH HOH A . 
S 6 HOH 383 2383 160  HOH HOH A . 
S 6 HOH 384 2384 472  HOH HOH A . 
S 6 HOH 385 2385 259  HOH HOH A . 
S 6 HOH 386 2386 70   HOH HOH A . 
S 6 HOH 387 2387 414  HOH HOH A . 
S 6 HOH 388 2388 332  HOH HOH A . 
S 6 HOH 389 2389 256  HOH HOH A . 
S 6 HOH 390 2390 347  HOH HOH A . 
S 6 HOH 391 2391 369  HOH HOH A . 
S 6 HOH 392 2392 33   HOH HOH A . 
S 6 HOH 393 2393 73   HOH HOH A . 
S 6 HOH 394 2394 15   HOH HOH A . 
S 6 HOH 395 2395 60   HOH HOH A . 
S 6 HOH 396 2396 296  HOH HOH A . 
S 6 HOH 397 2397 99   HOH HOH A . 
S 6 HOH 398 2398 22   HOH HOH A . 
S 6 HOH 399 2399 437  HOH HOH A . 
S 6 HOH 400 2400 80   HOH HOH A . 
S 6 HOH 401 2401 335  HOH HOH A . 
S 6 HOH 402 2402 344  HOH HOH A . 
S 6 HOH 403 2403 425  HOH HOH A . 
S 6 HOH 404 2404 309  HOH HOH A . 
S 6 HOH 405 2405 418  HOH HOH A . 
S 6 HOH 406 2406 466  HOH HOH A . 
S 6 HOH 407 2407 428  HOH HOH A . 
S 6 HOH 408 2408 93   HOH HOH A . 
S 6 HOH 409 2409 422  HOH HOH A . 
S 6 HOH 410 2410 410  HOH HOH A . 
S 6 HOH 411 2411 367  HOH HOH A . 
S 6 HOH 412 2412 443  HOH HOH A . 
S 6 HOH 413 2413 388  HOH HOH A . 
S 6 HOH 414 2414 477  HOH HOH A . 
S 6 HOH 415 2415 208  HOH HOH A . 
S 6 HOH 416 2416 394  HOH HOH A . 
S 6 HOH 417 2417 376  HOH HOH A . 
S 6 HOH 418 2418 375  HOH HOH A . 
S 6 HOH 419 2419 426  HOH HOH A . 
S 6 HOH 420 2420 380  HOH HOH A . 
S 6 HOH 421 2421 436  HOH HOH A . 
S 6 HOH 422 2422 464  HOH HOH A . 
S 6 HOH 423 2423 355  HOH HOH A . 
S 6 HOH 424 2424 449  HOH HOH A . 
S 6 HOH 425 2425 235  HOH HOH A . 
S 6 HOH 426 2426 310  HOH HOH A . 
S 6 HOH 427 2427 484  HOH HOH A . 
S 6 HOH 428 2428 423  HOH HOH A . 
S 6 HOH 429 2429 154  HOH HOH A . 
S 6 HOH 430 2430 52   HOH HOH A . 
S 6 HOH 431 2431 450  HOH HOH A . 
S 6 HOH 432 2432 307  HOH HOH A . 
S 6 HOH 433 2433 123  HOH HOH A . 
S 6 HOH 434 2434 358  HOH HOH A . 
S 6 HOH 435 2435 387  HOH HOH A . 
S 6 HOH 436 2436 65   HOH HOH A . 
S 6 HOH 437 2437 213  HOH HOH A . 
S 6 HOH 438 2438 391  HOH HOH A . 
S 6 HOH 439 2439 64   HOH HOH A . 
S 6 HOH 440 2440 363  HOH HOH A . 
S 6 HOH 441 2441 378  HOH HOH A . 
S 6 HOH 442 2442 398  HOH HOH A . 
S 6 HOH 443 2443 142  HOH HOH A . 
S 6 HOH 444 2444 38   HOH HOH A . 
S 6 HOH 445 2445 291  HOH HOH A . 
S 6 HOH 446 2446 390  HOH HOH A . 
S 6 HOH 447 2447 396  HOH HOH A . 
S 6 HOH 448 2448 34   HOH HOH A . 
S 6 HOH 449 2449 176  HOH HOH A . 
S 6 HOH 450 2450 149  HOH HOH A . 
S 6 HOH 451 2451 299  HOH HOH A . 
S 6 HOH 452 2452 320  HOH HOH A . 
S 6 HOH 453 2453 382  HOH HOH A . 
S 6 HOH 454 2454 329  HOH HOH A . 
S 6 HOH 455 2455 284  HOH HOH A . 
S 6 HOH 456 2456 247  HOH HOH A . 
S 6 HOH 457 2457 67   HOH HOH A . 
S 6 HOH 458 2458 481  HOH HOH A . 
S 6 HOH 459 2459 209  HOH HOH A . 
S 6 HOH 460 2460 319  HOH HOH A . 
S 6 HOH 461 2461 252  HOH HOH A . 
S 6 HOH 462 2462 383  HOH HOH A . 
S 6 HOH 463 2463 479  HOH HOH A . 
S 6 HOH 464 2464 446  HOH HOH A . 
S 6 HOH 465 2465 348  HOH HOH A . 
S 6 HOH 466 2466 439  HOH HOH A . 
S 6 HOH 467 2467 339  HOH HOH A . 
S 6 HOH 468 2468 268  HOH HOH A . 
S 6 HOH 469 2469 323  HOH HOH A . 
S 6 HOH 470 2470 452  HOH HOH A . 
S 6 HOH 471 2471 12   HOH HOH A . 
S 6 HOH 472 2472 136  HOH HOH A . 
S 6 HOH 473 2473 433  HOH HOH A . 
S 6 HOH 474 2474 304  HOH HOH A . 
S 6 HOH 475 2475 469  HOH HOH A . 
S 6 HOH 476 2476 372  HOH HOH A . 
S 6 HOH 477 2477 297  HOH HOH A . 
S 6 HOH 478 2478 468  HOH HOH A . 
S 6 HOH 479 2479 322  HOH HOH A . 
S 6 HOH 480 2480 337  HOH HOH A . 
S 6 HOH 481 2481 359  HOH HOH A . 
S 6 HOH 482 2482 61   HOH HOH A . 
S 6 HOH 483 2483 465  HOH HOH A . 
S 6 HOH 484 2484 346  HOH HOH A . 
S 6 HOH 485 2485 400  HOH HOH A . 
S 6 HOH 486 2486 113  HOH HOH A . 
S 6 HOH 487 2487 352  HOH HOH A . 
S 6 HOH 488 2488 343  HOH HOH A . 
S 6 HOH 489 2489 62   HOH HOH A . 
S 6 HOH 490 2490 336  HOH HOH A . 
S 6 HOH 491 2491 274  HOH HOH A . 
S 6 HOH 492 2492 424  HOH HOH A . 
S 6 HOH 493 2493 357  HOH HOH A . 
S 6 HOH 494 2494 374  HOH HOH A . 
S 6 HOH 495 2495 399  HOH HOH A . 
S 6 HOH 496 2496 75   HOH HOH A . 
S 6 HOH 497 2497 293  HOH HOH A . 
S 6 HOH 498 2498 432  HOH HOH A . 
S 6 HOH 499 2499 403  HOH HOH A . 
S 6 HOH 500 2500 365  HOH HOH A . 
S 6 HOH 501 2501 313  HOH HOH A . 
S 6 HOH 502 2502 351  HOH HOH A . 
S 6 HOH 503 2503 406  HOH HOH A . 
S 6 HOH 504 2504 39   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 1460 ? CG  ? A LYS 1   CG  
2  1 Y 1 A LYS 1460 ? CD  ? A LYS 1   CD  
3  1 Y 1 A LYS 1460 ? CE  ? A LYS 1   CE  
4  1 Y 1 A LYS 1460 ? NZ  ? A LYS 1   NZ  
5  1 Y 1 A ARG 1507 ? CG  ? A ARG 48  CG  
6  1 Y 1 A ARG 1507 ? CD  ? A ARG 48  CD  
7  1 Y 1 A ARG 1507 ? NE  ? A ARG 48  NE  
8  1 Y 1 A ARG 1507 ? CZ  ? A ARG 48  CZ  
9  1 Y 1 A ARG 1507 ? NH1 ? A ARG 48  NH1 
10 1 Y 1 A ARG 1507 ? NH2 ? A ARG 48  NH2 
11 1 Y 1 A GLU 1561 ? CG  ? A GLU 102 CG  
12 1 Y 1 A GLU 1561 ? CD  ? A GLU 102 CD  
13 1 Y 1 A GLU 1561 ? OE1 ? A GLU 102 OE1 
14 1 Y 1 A GLU 1561 ? OE2 ? A GLU 102 OE2 
15 1 Y 1 A ARG 1567 ? CG  ? A ARG 108 CG  
16 1 Y 1 A ARG 1567 ? CD  ? A ARG 108 CD  
17 1 Y 1 A ARG 1567 ? NE  ? A ARG 108 NE  
18 1 Y 1 A ARG 1567 ? CZ  ? A ARG 108 CZ  
19 1 Y 1 A ARG 1567 ? NH1 ? A ARG 108 NH1 
20 1 Y 1 A ARG 1567 ? NH2 ? A ARG 108 NH2 
21 1 Y 1 A ASP 1569 ? CG  ? A ASP 110 CG  
22 1 Y 1 A ASP 1569 ? OD1 ? A ASP 110 OD1 
23 1 Y 1 A ASP 1569 ? OD2 ? A ASP 110 OD2 
24 1 Y 1 A ARG 1667 ? CG  ? A ARG 208 CG  
25 1 Y 1 A ARG 1667 ? CD  ? A ARG 208 CD  
26 1 Y 1 A ARG 1667 ? NE  ? A ARG 208 NE  
27 1 Y 1 A ARG 1667 ? CZ  ? A ARG 208 CZ  
28 1 Y 1 A ARG 1667 ? NH1 ? A ARG 208 NH1 
29 1 Y 1 A ARG 1667 ? NH2 ? A ARG 208 NH2 
30 1 Y 1 A ARG 1699 ? CG  ? A ARG 240 CG  
31 1 Y 1 A ARG 1699 ? CD  ? A ARG 240 CD  
32 1 Y 1 A ARG 1699 ? NE  ? A ARG 240 NE  
33 1 Y 1 A ARG 1699 ? CZ  ? A ARG 240 CZ  
34 1 Y 1 A ARG 1699 ? NH1 ? A ARG 240 NH1 
35 1 Y 1 A ARG 1699 ? NH2 ? A ARG 240 NH2 
36 1 Y 0 A SER 1767 ? CA  A A SER 308 CA  
37 1 Y 0 A SER 1767 ? CB  A A SER 308 CB  
38 1 Y 0 A SER 1767 ? OG  A A SER 308 OG  
39 1 Y 1 A LYS 1811 ? CG  ? A LYS 352 CG  
40 1 Y 1 A LYS 1811 ? CD  ? A LYS 352 CD  
41 1 Y 1 A LYS 1811 ? CE  ? A LYS 352 CE  
42 1 Y 1 A LYS 1811 ? NZ  ? A LYS 352 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? EDNA     ? ? ? .           1 
? 'data processing' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless  ? ? ? .           3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? 'CCP4 v8.0' 4 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 'CCP4 v8.0' 5 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.20.1_4487 6 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FS2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     82.142 
_cell.length_a_esd                 ? 
_cell.length_b                     158.579 
_cell.length_b_esd                 ? 
_cell.length_c                     61.950 
_cell.length_c_esd                 ? 
_cell.volume                       806960.466 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FS2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FS2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.53 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          51.36 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES pH 7, 2.5 M sodium formate, 2 mM carbamoyl aspartate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 X 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-04-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97926 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALBA BEAMLINE XALOC' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97926 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   XALOC 
_diffrn_source.pdbx_synchrotron_site       ALBA 
# 
_reflns.B_iso_Wilson_estimate                          10.97 
_reflns.entry_id                                       9FS2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.12 
_reflns.d_resolution_low                               47.22 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     152076 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.80 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.26 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.12 
_reflns_shell.d_res_low                                     1.16 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.68 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             13868 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.459 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               16.65 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FS2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.12 
_refine.ls_d_res_low                             47.22 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     152046 
_refine.ls_number_reflns_R_free                  7624 
_refine.ls_number_reflns_R_work                  144422 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.80 
_refine.ls_percent_reflns_R_free                 5.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1479 
_refine.ls_R_factor_R_free                       0.1688 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1468 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.2177 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1400 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.12 
_refine_hist.d_res_low                        47.22 
_refine_hist.number_atoms_solvent             504 
_refine_hist.number_atoms_total               3317 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2753 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         60 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0136 ? 3104 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.3283 ? 4252 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0995 ? 481  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0131 ? 565  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.2077 ? 442  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.12 1.13  . . 240 4218 88.00  . . . . 0.3454 . . . . . . . . . . . 0.3567 
'X-RAY DIFFRACTION' 1.13 1.15  . . 219 4447 91.51  . . . . 0.3303 . . . . . . . . . . . 0.3308 
'X-RAY DIFFRACTION' 1.15 1.16  . . 232 4508 93.75  . . . . 0.3274 . . . . . . . . . . . 0.3498 
'X-RAY DIFFRACTION' 1.16 1.18  . . 229 4718 96.73  . . . . 0.3116 . . . . . . . . . . . 0.3185 
'X-RAY DIFFRACTION' 1.18 1.19  . . 252 4745 97.83  . . . . 0.2987 . . . . . . . . . . . 0.2913 
'X-RAY DIFFRACTION' 1.19 1.21  . . 215 4819 98.94  . . . . 0.2838 . . . . . . . . . . . 0.3037 
'X-RAY DIFFRACTION' 1.21 1.23  . . 244 4760 99.03  . . . . 0.2760 . . . . . . . . . . . 0.3102 
'X-RAY DIFFRACTION' 1.23 1.24  . . 232 4822 99.12  . . . . 0.2684 . . . . . . . . . . . 0.2961 
'X-RAY DIFFRACTION' 1.24 1.26  . . 258 4860 99.57  . . . . 0.2505 . . . . . . . . . . . 0.2675 
'X-RAY DIFFRACTION' 1.26 1.28  . . 254 4788 99.76  . . . . 0.2353 . . . . . . . . . . . 0.2560 
'X-RAY DIFFRACTION' 1.28 1.31  . . 239 4840 99.90  . . . . 0.2213 . . . . . . . . . . . 0.2253 
'X-RAY DIFFRACTION' 1.31 1.33  . . 266 4828 99.90  . . . . 0.2186 . . . . . . . . . . . 0.2275 
'X-RAY DIFFRACTION' 1.33 1.36  . . 255 4842 99.94  . . . . 0.2098 . . . . . . . . . . . 0.2220 
'X-RAY DIFFRACTION' 1.36 1.38  . . 273 4823 99.98  . . . . 0.1954 . . . . . . . . . . . 0.2369 
'X-RAY DIFFRACTION' 1.38 1.41  . . 263 4855 99.94  . . . . 0.1812 . . . . . . . . . . . 0.2024 
'X-RAY DIFFRACTION' 1.41 1.45  . . 280 4820 99.96  . . . . 0.1752 . . . . . . . . . . . 0.2018 
'X-RAY DIFFRACTION' 1.45 1.48  . . 273 4841 99.96  . . . . 0.1603 . . . . . . . . . . . 0.1926 
'X-RAY DIFFRACTION' 1.48 1.52  . . 266 4837 99.98  . . . . 0.1341 . . . . . . . . . . . 0.1679 
'X-RAY DIFFRACTION' 1.52 1.57  . . 237 4882 100.00 . . . . 0.1230 . . . . . . . . . . . 0.1824 
'X-RAY DIFFRACTION' 1.57 1.62  . . 237 4881 99.96  . . . . 0.1154 . . . . . . . . . . . 0.1488 
'X-RAY DIFFRACTION' 1.62 1.68  . . 257 4889 99.98  . . . . 0.1100 . . . . . . . . . . . 0.1362 
'X-RAY DIFFRACTION' 1.68 1.74  . . 251 4877 100.00 . . . . 0.1078 . . . . . . . . . . . 0.1465 
'X-RAY DIFFRACTION' 1.74 1.82  . . 250 4894 100.00 . . . . 0.1092 . . . . . . . . . . . 0.1468 
'X-RAY DIFFRACTION' 1.82 1.92  . . 276 4840 100.00 . . . . 0.1078 . . . . . . . . . . . 0.1399 
'X-RAY DIFFRACTION' 1.92 2.04  . . 237 4931 100.00 . . . . 0.1040 . . . . . . . . . . . 0.1194 
'X-RAY DIFFRACTION' 2.04 2.20  . . 286 4887 99.98  . . . . 0.1019 . . . . . . . . . . . 0.1177 
'X-RAY DIFFRACTION' 2.20 2.42  . . 273 4918 100.00 . . . . 0.1069 . . . . . . . . . . . 0.1379 
'X-RAY DIFFRACTION' 2.42 2.77  . . 253 4934 99.98  . . . . 0.1177 . . . . . . . . . . . 0.1400 
'X-RAY DIFFRACTION' 2.77 3.49  . . 271 4980 100.00 . . . . 0.1248 . . . . . . . . . . . 0.1390 
'X-RAY DIFFRACTION' 3.49 47.22 . . 306 5138 99.94  . . . . 0.1318 . . . . . . . . . . . 0.1517 
# 
_struct.entry_id                     9FS2 
_struct.title                        'Mutant S1538A of the dihydroorotase domain of human CAD protein bound to substrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FS2 
_struct_keywords.text            
'Nucleotide metabolism, de novo pyrimidine synthesis, CAD disease, multienzymatic protein, zinc, carboxylated lysine, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 5 ? 
J N N 5 ? 
K N N 5 ? 
L N N 5 ? 
M N N 5 ? 
N N N 2 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 5 ? 
R N N 5 ? 
S N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PYR1_HUMAN 
_struct_ref.pdbx_db_accession          P27708 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASS
ENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKE
EILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSR
PPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKV
KGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLP
;
_struct_ref.pdbx_align_begin           1460 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FS2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 362 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P27708 
_struct_ref_seq.db_align_beg                  1460 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1821 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1460 
_struct_ref_seq.pdbx_auth_seq_align_end       1821 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9FS2 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      79 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P27708 
_struct_ref_seq_dif.db_mon_id                    SER 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          1538 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            1538 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 7940  ? 
1 MORE         -337  ? 
1 'SSA (A^2)'  25070 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 3_554 -x,y,-z-1/2 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -30.9750000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 25  ? GLY A 36  ? ASP A 1484 GLY A 1495 1 ? 12 
HELX_P HELX_P2  AA2 ASP A 53  ? ALA A 68  ? ASP A 1512 ALA A 1527 1 ? 16 
HELX_P HELX_P3  AA3 VAL A 89  ? ALA A 93  ? VAL A 1548 ALA A 1552 5 ? 5  
HELX_P HELX_P4  AA4 SER A 111 ? TRP A 122 ? SER A 1570 TRP A 1581 1 ? 12 
HELX_P HELX_P5  AA5 GLN A 134 ? THR A 147 ? GLN A 1593 THR A 1606 1 ? 14 
HELX_P HELX_P6  AA6 ARG A 158 ? ARG A 171 ? ARG A 1617 ARG A 1630 1 ? 14 
HELX_P HELX_P7  AA7 ALA A 180 ? LEU A 186 ? ALA A 1639 LEU A 1645 1 ? 7  
HELX_P HELX_P8  AA8 SER A 187 ? ASP A 189 ? SER A 1646 ASP A 1648 5 ? 3  
HELX_P HELX_P9  AA9 ASP A 190 ? GLY A 199 ? ASP A 1649 GLY A 1658 1 ? 10 
HELX_P HELX_P10 AB1 SER A 207 ? ASN A 217 ? SER A 1666 ASN A 1676 1 ? 11 
HELX_P HELX_P11 AB2 MET A 218 ? ILE A 221 ? MET A 1677 ILE A 1680 5 ? 4  
HELX_P HELX_P12 AB3 THR A 232 ? CYS A 237 ? THR A 1691 CYS A 1696 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 247 ? GLU A 261 ? GLY A 1706 GLU A 1720 1 ? 15 
HELX_P HELX_P14 AB5 SER A 265 ? HIS A 274 ? SER A 1724 HIS A 1733 1 ? 10 
HELX_P HELX_P15 AB6 HIS A 274 ? HIS A 282 ? HIS A 1733 HIS A 1741 1 ? 9  
HELX_P HELX_P16 AB7 ASP A 349 ? ALA A 357 ? ASP A 1808 ALA A 1816 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? A LEU 96  C   ? ? ? 1_555 A KCX 97 N  ? ? A LEU 1555 A KCX 1556 1_555 ? ? ? ? ? ? ? 1.339 ? ? 
covale2  covale both ? A KCX 97  C   ? ? ? 1_555 A LEU 98 N  ? ? A KCX 1556 A LEU 1557 1_555 ? ? ? ? ? ? ? 1.355 ? ? 
metalc1  metalc ?    ? A HIS 12  NE2 ? ? ? 1_555 B ZN  .  ZN ? ? A HIS 1471 A ZN  1901 1_555 ? ? ? ? ? ? ? 2.049 ? ? 
metalc2  metalc ?    ? A HIS 12  ND1 ? ? ? 1_555 E ZN  .  ZN ? ? A HIS 1471 A ZN  1904 1_555 ? ? ? ? ? ? ? 2.089 ? ? 
metalc3  metalc ?    ? A HIS 14  NE2 ? ? ? 1_555 B ZN  .  ZN ? ? A HIS 1473 A ZN  1901 1_555 ? ? ? ? ? ? ? 2.055 ? ? 
metalc4  metalc ?    ? A KCX 97  OQ2 ? ? ? 1_555 B ZN  .  ZN ? ? A KCX 1556 A ZN  1901 1_555 ? ? ? ? ? ? ? 2.260 ? ? 
metalc5  metalc ?    ? A KCX 97  OQ1 ? ? ? 1_555 C ZN  .  ZN ? ? A KCX 1556 A ZN  1902 1_555 ? ? ? ? ? ? ? 1.950 ? ? 
metalc6  metalc ?    ? A HIS 131 ND1 ? ? ? 1_555 C ZN  .  ZN ? ? A HIS 1590 A ZN  1902 1_555 ? ? ? ? ? ? ? 2.089 ? ? 
metalc7  metalc ?    ? A CYS 154 SG  ? ? ? 1_555 E ZN  .  ZN ? ? A CYS 1613 A ZN  1904 1_555 ? ? ? ? ? ? ? 2.386 ? ? 
metalc8  metalc ?    ? A HIS 155 NE2 ? ? ? 1_555 C ZN  .  ZN ? ? A HIS 1614 A ZN  1902 1_555 ? ? ? ? ? ? ? 2.078 ? ? 
metalc9  metalc ?    ? A GLU 178 OE2 ? ? ? 1_555 E ZN  .  ZN ? ? A GLU 1637 A ZN  1904 1_555 ? ? ? ? ? ? ? 2.189 ? ? 
metalc10 metalc ?    ? A ASP 227 OD1 ? ? ? 1_555 B ZN  .  ZN ? ? A ASP 1686 A ZN  1901 1_555 ? ? ? ? ? ? ? 2.116 ? ? 
metalc11 metalc ?    ? A HIS 275 NE2 ? ? ? 1_555 N ZN  .  ZN ? ? A HIS 1734 A ZN  1913 3_554 ? ? ? ? ? ? ? 2.073 ? ? 
metalc12 metalc ?    ? A HIS 282 ND1 A ? ? 1_555 N ZN  .  ZN ? ? A HIS 1741 A ZN  1913 1_555 ? ? ? ? ? ? ? 2.141 ? ? 
metalc13 metalc ?    ? B ZN  .   ZN  ? ? ? 1_555 D NCD .  O4 A ? A ZN  1901 A NCD 1903 1_555 ? ? ? ? ? ? ? 1.895 ? ? 
metalc14 metalc ?    ? B ZN  .   ZN  ? ? ? 1_555 S HOH .  O  B ? A ZN  1901 A HOH 2212 1_555 ? ? ? ? ? ? ? 2.116 ? ? 
metalc15 metalc ?    ? C ZN  .   ZN  ? ? ? 1_555 D NCD .  O4 A ? A ZN  1902 A NCD 1903 1_555 ? ? ? ? ? ? ? 2.262 ? ? 
metalc16 metalc ?    ? C ZN  .   ZN  ? ? ? 1_555 D NCD .  O5 A ? A ZN  1902 A NCD 1903 1_555 ? ? ? ? ? ? ? 2.118 ? ? 
metalc17 metalc ?    ? C ZN  .   ZN  ? ? ? 1_555 S HOH .  O  B ? A ZN  1902 A HOH 2212 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
metalc18 metalc ?    ? E ZN  .   ZN  ? ? ? 1_555 S HOH .  O  ? ? A ZN  1904 A HOH 2191 1_555 ? ? ? ? ? ? ? 2.065 ? ? 
metalc19 metalc ?    ? N ZN  .   ZN  ? ? ? 1_555 S HOH .  O  ? ? A ZN  1913 A HOH 2357 1_555 ? ? ? ? ? ? ? 2.021 ? ? 
metalc20 metalc ?    ? N ZN  .   ZN  ? ? ? 1_555 S HOH .  O  ? ? A ZN  1913 A HOH 2366 1_555 ? ? ? ? ? ? ? 2.219 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 NE2 ? A HIS 14  ? A HIS 1473 ? 1_555 116.5 ? 
2  NE2 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 OQ2 ? A KCX 97  ? A KCX 1556 ? 1_555 90.4  ? 
3  NE2 ? A HIS 14  ? A HIS 1473 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 OQ2 ? A KCX 97  ? A KCX 1556 ? 1_555 90.1  ? 
4  NE2 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 OD1 ? A ASP 227 ? A ASP 1686 ? 1_555 84.7  ? 
5  NE2 ? A HIS 14  ? A HIS 1473 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 OD1 ? A ASP 227 ? A ASP 1686 ? 1_555 92.4  ? 
6  OQ2 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 OD1 ? A ASP 227 ? A ASP 1686 ? 1_555 175.1 ? 
7  NE2 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 122.0 ? 
8  NE2 ? A HIS 14  ? A HIS 1473 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 121.4 ? 
9  OQ2 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 86.8  ? 
10 OD1 ? A ASP 227 ? A ASP 1686 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 95.4  ? 
11 NE2 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 113.3 ? 
12 NE2 ? A HIS 14  ? A HIS 1473 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 130.2 ? 
13 OQ2 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 89.2  ? 
14 OD1 ? A ASP 227 ? A ASP 1686 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 92.4  ? 
15 O4  A D NCD .   ? A NCD 1903 ? 1_555 ZN ? B ZN . ? A ZN 1901 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 9.1   ? 
16 ND1 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 SG  ? A CYS 154 ? A CYS 1613 ? 1_555 114.5 ? 
17 ND1 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 OE2 ? A GLU 178 ? A GLU 1637 ? 1_555 81.4  ? 
18 SG  ? A CYS 154 ? A CYS 1613 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 OE2 ? A GLU 178 ? A GLU 1637 ? 1_555 115.1 ? 
19 ND1 ? A HIS 12  ? A HIS 1471 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 O   ? S HOH .   ? A HOH 2191 ? 1_555 124.5 ? 
20 SG  ? A CYS 154 ? A CYS 1613 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 O   ? S HOH .   ? A HOH 2191 ? 1_555 107.5 ? 
21 OE2 ? A GLU 178 ? A GLU 1637 ? 1_555 ZN ? E ZN . ? A ZN 1904 ? 1_555 O   ? S HOH .   ? A HOH 2191 ? 1_555 111.9 ? 
22 OQ1 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 ND1 ? A HIS 131 ? A HIS 1590 ? 1_555 106.7 ? 
23 OQ1 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 NE2 ? A HIS 155 ? A HIS 1614 ? 1_555 109.6 ? 
24 ND1 ? A HIS 131 ? A HIS 1590 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 NE2 ? A HIS 155 ? A HIS 1614 ? 1_555 93.5  ? 
25 OQ1 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 95.4  ? 
26 ND1 ? A HIS 131 ? A HIS 1590 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 145.5 ? 
27 NE2 ? A HIS 155 ? A HIS 1614 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O4  A D NCD .   ? A NCD 1903 ? 1_555 103.9 ? 
28 OQ1 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O5  A D NCD .   ? A NCD 1903 ? 1_555 114.5 ? 
29 ND1 ? A HIS 131 ? A HIS 1590 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O5  A D NCD .   ? A NCD 1903 ? 1_555 87.3  ? 
30 NE2 ? A HIS 155 ? A HIS 1614 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O5  A D NCD .   ? A NCD 1903 ? 1_555 133.6 ? 
31 O4  A D NCD .   ? A NCD 1903 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O5  A D NCD .   ? A NCD 1903 ? 1_555 59.1  ? 
32 OQ1 ? A KCX 97  ? A KCX 1556 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 100.6 ? 
33 ND1 ? A HIS 131 ? A HIS 1590 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 146.1 ? 
34 NE2 ? A HIS 155 ? A HIS 1614 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 96.0  ? 
35 O4  A D NCD .   ? A NCD 1903 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 8.3   ? 
36 O5  A D NCD .   ? A NCD 1903 ? 1_555 ZN ? C ZN . ? A ZN 1902 ? 1_555 O   B S HOH .   ? A HOH 2212 ? 1_555 62.8  ? 
37 NE2 ? A HIS 275 ? A HIS 1734 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 ND1 A A HIS 282 ? A HIS 1741 ? 1_555 28.2  ? 
38 NE2 ? A HIS 275 ? A HIS 1734 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 O   ? S HOH .   ? A HOH 2357 ? 1_555 37.6  ? 
39 ND1 A A HIS 282 ? A HIS 1741 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 O   ? S HOH .   ? A HOH 2357 ? 1_555 11.3  ? 
40 NE2 ? A HIS 275 ? A HIS 1734 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 O   ? S HOH .   ? A HOH 2366 ? 1_555 40.3  ? 
41 ND1 A A HIS 282 ? A HIS 1741 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 O   ? S HOH .   ? A HOH 2366 ? 1_555 12.8  ? 
42 O   ? S HOH .   ? A HOH 2357 ? 1_555 ZN ? N ZN . ? A ZN 1913 ? 3_554 O   ? S HOH .   ? A HOH 2366 ? 1_555 12.2  ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      KCX 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       97 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       KCX 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        1556 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                LYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        KCX 
_pdbx_modification_feature.type                               Carboxylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 17  A . ? GLU 1476 A PRO 18  A ? PRO 1477 A 1 8.27   
2 ARG 48  A . ? ARG 1507 A PRO 49  A ? PRO 1508 A 1 -0.35  
3 ARG 202 A . ? ARG 1661 A PRO 203 A ? PRO 1662 A 1 -11.90 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 3   ? PRO A 6   ? VAL A 1462 PRO A 1465 
AA1 2 TYR A 290 ? THR A 300 ? TYR A 1749 THR A 1759 
AA1 3 LYS A 319 ? LEU A 329 ? LYS A 1778 LEU A 1788 
AA1 4 GLU A 332 ? ILE A 336 ? GLU A 1791 ILE A 1795 
AA1 5 GLN A 339 ? VAL A 340 ? GLN A 1798 VAL A 1799 
AA2 1 LEU A 8   ? VAL A 13  ? LEU A 1467 VAL A 1472 
AA2 2 ILE A 38  ? ALA A 43  ? ILE A 1497 ALA A 1502 
AA2 3 ASP A 71  ? LEU A 74  ? ASP A 1530 LEU A 1533 
AA3 1 LEU A 76  ? GLY A 77  ? LEU A 1535 GLY A 1536 
AA3 2 LEU A 96  ? TYR A 99  ? LEU A 1555 TYR A 1558 
AA3 3 ILE A 128 ? HIS A 131 ? ILE A 1587 HIS A 1590 
AA3 4 VAL A 151 ? ILE A 153 ? VAL A 1610 ILE A 1612 
AA3 5 VAL A 175 ? VAL A 179 ? VAL A 1634 VAL A 1638 
AA3 6 CYS A 223 ? PHE A 224 ? CYS A 1682 PHE A 1683 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 5   ? N LEU A 1464 O VAL A 291 ? O VAL A 1750 
AA1 2 3 N GLU A 292 ? N GLU A 1751 O ARG A 326 ? O ARG A 1785 
AA1 3 4 N VAL A 327 ? N VAL A 1786 O ALA A 334 ? O ALA A 1793 
AA1 4 5 N ILE A 336 ? N ILE A 1795 O GLN A 339 ? O GLN A 1798 
AA2 1 2 N ASP A 10  ? N ASP A 1469 O MET A 40  ? O MET A 1499 
AA2 2 3 N ALA A 43  ? N ALA A 1502 O ALA A 73  ? O ALA A 1532 
AA3 1 2 N LEU A 76  ? N LEU A 1535 O KCX A 97  ? O KCX A 1556 
AA3 2 3 N LEU A 96  ? N LEU A 1555 O VAL A 129 ? O VAL A 1588 
AA3 3 4 N ALA A 130 ? N ALA A 1589 O HIS A 152 ? O HIS A 1611 
AA3 4 5 N ILE A 153 ? N ILE A 1612 O THR A 176 ? O THR A 1635 
AA3 5 6 N VAL A 179 ? N VAL A 1638 O CYS A 223 ? O CYS A 1682 
# 
_pdbx_entry_details.entry_id                   9FS2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             MET 
_pdbx_validate_rmsd_angle.auth_seq_id_1              1601 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             B 
_pdbx_validate_rmsd_angle.auth_atom_id_2             SD 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             MET 
_pdbx_validate_rmsd_angle.auth_seq_id_2              1601 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             B 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CE 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             MET 
_pdbx_validate_rmsd_angle.auth_seq_id_3              1601 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             B 
_pdbx_validate_rmsd_angle.angle_value                111.97 
_pdbx_validate_rmsd_angle.angle_target_value         100.20 
_pdbx_validate_rmsd_angle.angle_deviation            11.77 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.60 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ARG A 1475 ? ? 71.07   -5.12   
2  1 GLU A 1483 ? ? 175.47  155.92  
3  1 ASN A 1505 ? ? -86.70  45.91   
4  1 ASN A 1560 ? B -118.34 -134.27 
5  1 THR A 1562 ? A -166.91 -167.55 
6  1 LEU A 1566 ? A -95.35  55.75   
7  1 ARG A 1567 ? A -49.14  -73.75  
8  1 LEU A 1568 ? A 72.38   111.26  
9  1 GLN A 1593 ? ? 54.52   -127.03 
10 1 HIS A 1614 ? ? 22.26   76.44   
11 1 HIS A 1733 ? ? -151.00 -68.73  
12 1 ASP A 1796 ? ? 37.39   49.25   
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    KCX 
_pdbx_struct_mod_residue.label_seq_id     97 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     KCX 
_pdbx_struct_mod_residue.auth_seq_id      1556 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   LYS 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 2400 ? S HOH . 
2 1 A HOH 2432 ? S HOH . 
3 1 A HOH 2462 ? S HOH . 
4 1 A HOH 2495 ? S HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 x,-y,-z             
3 -x,y,-z+1/2         
4 -x,-y,z+1/2         
5 x+1/2,y+1/2,z       
6 x+1/2,-y+1/2,-z     
7 -x+1/2,y+1/2,-z+1/2 
8 -x+1/2,-y+1/2,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 2501 ? 6.02  . 
2 1 O ? A HOH 2502 ? 6.96  . 
3 1 O ? A HOH 2503 ? 7.08  . 
4 1 O ? A HOH 2504 ? 15.54 . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
DOR O2   O  N N 88  
DOR C2   C  N N 89  
DOR N1   N  N N 90  
DOR N3   N  N N 91  
DOR C4   C  N N 92  
DOR O4   O  N N 93  
DOR C5   C  N N 94  
DOR C6   C  N S 95  
DOR C7   C  N N 96  
DOR O72  O  N N 97  
DOR O71  O  N N 98  
DOR HN1  H  N N 99  
DOR HN3  H  N N 100 
DOR H51  H  N N 101 
DOR H52  H  N N 102 
DOR H6   H  N N 103 
DOR H72  H  N N 104 
FMT C    C  N N 105 
FMT O1   O  N N 106 
FMT O2   O  N N 107 
FMT H    H  N N 108 
FMT HO2  H  N N 109 
GLN N    N  N N 110 
GLN CA   C  N S 111 
GLN C    C  N N 112 
GLN O    O  N N 113 
GLN CB   C  N N 114 
GLN CG   C  N N 115 
GLN CD   C  N N 116 
GLN OE1  O  N N 117 
GLN NE2  N  N N 118 
GLN OXT  O  N N 119 
GLN H    H  N N 120 
GLN H2   H  N N 121 
GLN HA   H  N N 122 
GLN HB2  H  N N 123 
GLN HB3  H  N N 124 
GLN HG2  H  N N 125 
GLN HG3  H  N N 126 
GLN HE21 H  N N 127 
GLN HE22 H  N N 128 
GLN HXT  H  N N 129 
GLU N    N  N N 130 
GLU CA   C  N S 131 
GLU C    C  N N 132 
GLU O    O  N N 133 
GLU CB   C  N N 134 
GLU CG   C  N N 135 
GLU CD   C  N N 136 
GLU OE1  O  N N 137 
GLU OE2  O  N N 138 
GLU OXT  O  N N 139 
GLU H    H  N N 140 
GLU H2   H  N N 141 
GLU HA   H  N N 142 
GLU HB2  H  N N 143 
GLU HB3  H  N N 144 
GLU HG2  H  N N 145 
GLU HG3  H  N N 146 
GLU HE2  H  N N 147 
GLU HXT  H  N N 148 
GLY N    N  N N 149 
GLY CA   C  N N 150 
GLY C    C  N N 151 
GLY O    O  N N 152 
GLY OXT  O  N N 153 
GLY H    H  N N 154 
GLY H2   H  N N 155 
GLY HA2  H  N N 156 
GLY HA3  H  N N 157 
GLY HXT  H  N N 158 
HIS N    N  N N 159 
HIS CA   C  N S 160 
HIS C    C  N N 161 
HIS O    O  N N 162 
HIS CB   C  N N 163 
HIS CG   C  Y N 164 
HIS ND1  N  Y N 165 
HIS CD2  C  Y N 166 
HIS CE1  C  Y N 167 
HIS NE2  N  Y N 168 
HIS OXT  O  N N 169 
HIS H    H  N N 170 
HIS H2   H  N N 171 
HIS HA   H  N N 172 
HIS HB2  H  N N 173 
HIS HB3  H  N N 174 
HIS HD1  H  N N 175 
HIS HD2  H  N N 176 
HIS HE1  H  N N 177 
HIS HE2  H  N N 178 
HIS HXT  H  N N 179 
HOH O    O  N N 180 
HOH H1   H  N N 181 
HOH H2   H  N N 182 
ILE N    N  N N 183 
ILE CA   C  N S 184 
ILE C    C  N N 185 
ILE O    O  N N 186 
ILE CB   C  N S 187 
ILE CG1  C  N N 188 
ILE CG2  C  N N 189 
ILE CD1  C  N N 190 
ILE OXT  O  N N 191 
ILE H    H  N N 192 
ILE H2   H  N N 193 
ILE HA   H  N N 194 
ILE HB   H  N N 195 
ILE HG12 H  N N 196 
ILE HG13 H  N N 197 
ILE HG21 H  N N 198 
ILE HG22 H  N N 199 
ILE HG23 H  N N 200 
ILE HD11 H  N N 201 
ILE HD12 H  N N 202 
ILE HD13 H  N N 203 
ILE HXT  H  N N 204 
KCX N    N  N N 205 
KCX CA   C  N S 206 
KCX CB   C  N N 207 
KCX CG   C  N N 208 
KCX CD   C  N N 209 
KCX CE   C  N N 210 
KCX NZ   N  N N 211 
KCX C    C  N N 212 
KCX O    O  N N 213 
KCX CX   C  N N 214 
KCX OXT  O  N N 215 
KCX OQ1  O  N N 216 
KCX OQ2  O  N N 217 
KCX H    H  N N 218 
KCX H2   H  N N 219 
KCX HA   H  N N 220 
KCX HB2  H  N N 221 
KCX HB3  H  N N 222 
KCX HG2  H  N N 223 
KCX HG3  H  N N 224 
KCX HD2  H  N N 225 
KCX HD3  H  N N 226 
KCX HE2  H  N N 227 
KCX HE3  H  N N 228 
KCX HZ   H  N N 229 
KCX HXT  H  N N 230 
KCX HQ2  H  N N 231 
LEU N    N  N N 232 
LEU CA   C  N S 233 
LEU C    C  N N 234 
LEU O    O  N N 235 
LEU CB   C  N N 236 
LEU CG   C  N N 237 
LEU CD1  C  N N 238 
LEU CD2  C  N N 239 
LEU OXT  O  N N 240 
LEU H    H  N N 241 
LEU H2   H  N N 242 
LEU HA   H  N N 243 
LEU HB2  H  N N 244 
LEU HB3  H  N N 245 
LEU HG   H  N N 246 
LEU HD11 H  N N 247 
LEU HD12 H  N N 248 
LEU HD13 H  N N 249 
LEU HD21 H  N N 250 
LEU HD22 H  N N 251 
LEU HD23 H  N N 252 
LEU HXT  H  N N 253 
LYS N    N  N N 254 
LYS CA   C  N S 255 
LYS C    C  N N 256 
LYS O    O  N N 257 
LYS CB   C  N N 258 
LYS CG   C  N N 259 
LYS CD   C  N N 260 
LYS CE   C  N N 261 
LYS NZ   N  N N 262 
LYS OXT  O  N N 263 
LYS H    H  N N 264 
LYS H2   H  N N 265 
LYS HA   H  N N 266 
LYS HB2  H  N N 267 
LYS HB3  H  N N 268 
LYS HG2  H  N N 269 
LYS HG3  H  N N 270 
LYS HD2  H  N N 271 
LYS HD3  H  N N 272 
LYS HE2  H  N N 273 
LYS HE3  H  N N 274 
LYS HZ1  H  N N 275 
LYS HZ2  H  N N 276 
LYS HZ3  H  N N 277 
LYS HXT  H  N N 278 
MET N    N  N N 279 
MET CA   C  N S 280 
MET C    C  N N 281 
MET O    O  N N 282 
MET CB   C  N N 283 
MET CG   C  N N 284 
MET SD   S  N N 285 
MET CE   C  N N 286 
MET OXT  O  N N 287 
MET H    H  N N 288 
MET H2   H  N N 289 
MET HA   H  N N 290 
MET HB2  H  N N 291 
MET HB3  H  N N 292 
MET HG2  H  N N 293 
MET HG3  H  N N 294 
MET HE1  H  N N 295 
MET HE2  H  N N 296 
MET HE3  H  N N 297 
MET HXT  H  N N 298 
NCD C6   C  N S 299 
NCD C61  C  N N 300 
NCD O61  O  N N 301 
NCD O62  O  N N 302 
NCD N1   N  N N 303 
NCD C2   C  N N 304 
NCD O2   O  N N 305 
NCD N3   N  N N 306 
NCD C5   C  N N 307 
NCD C4   C  N N 308 
NCD O4   O  N N 309 
NCD O5   O  N N 310 
NCD H61  H  N N 311 
NCD H611 H  N N 312 
NCD H11  H  N N 313 
NCD H31  H  N N 314 
NCD H32  H  N N 315 
NCD H51  H  N N 316 
NCD H52  H  N N 317 
NCD HO51 H  N N 318 
PHE N    N  N N 319 
PHE CA   C  N S 320 
PHE C    C  N N 321 
PHE O    O  N N 322 
PHE CB   C  N N 323 
PHE CG   C  Y N 324 
PHE CD1  C  Y N 325 
PHE CD2  C  Y N 326 
PHE CE1  C  Y N 327 
PHE CE2  C  Y N 328 
PHE CZ   C  Y N 329 
PHE OXT  O  N N 330 
PHE H    H  N N 331 
PHE H2   H  N N 332 
PHE HA   H  N N 333 
PHE HB2  H  N N 334 
PHE HB3  H  N N 335 
PHE HD1  H  N N 336 
PHE HD2  H  N N 337 
PHE HE1  H  N N 338 
PHE HE2  H  N N 339 
PHE HZ   H  N N 340 
PHE HXT  H  N N 341 
PRO N    N  N N 342 
PRO CA   C  N S 343 
PRO C    C  N N 344 
PRO O    O  N N 345 
PRO CB   C  N N 346 
PRO CG   C  N N 347 
PRO CD   C  N N 348 
PRO OXT  O  N N 349 
PRO H    H  N N 350 
PRO HA   H  N N 351 
PRO HB2  H  N N 352 
PRO HB3  H  N N 353 
PRO HG2  H  N N 354 
PRO HG3  H  N N 355 
PRO HD2  H  N N 356 
PRO HD3  H  N N 357 
PRO HXT  H  N N 358 
SER N    N  N N 359 
SER CA   C  N S 360 
SER C    C  N N 361 
SER O    O  N N 362 
SER CB   C  N N 363 
SER OG   O  N N 364 
SER OXT  O  N N 365 
SER H    H  N N 366 
SER H2   H  N N 367 
SER HA   H  N N 368 
SER HB2  H  N N 369 
SER HB3  H  N N 370 
SER HG   H  N N 371 
SER HXT  H  N N 372 
THR N    N  N N 373 
THR CA   C  N S 374 
THR C    C  N N 375 
THR O    O  N N 376 
THR CB   C  N R 377 
THR OG1  O  N N 378 
THR CG2  C  N N 379 
THR OXT  O  N N 380 
THR H    H  N N 381 
THR H2   H  N N 382 
THR HA   H  N N 383 
THR HB   H  N N 384 
THR HG1  H  N N 385 
THR HG21 H  N N 386 
THR HG22 H  N N 387 
THR HG23 H  N N 388 
THR HXT  H  N N 389 
TRP N    N  N N 390 
TRP CA   C  N S 391 
TRP C    C  N N 392 
TRP O    O  N N 393 
TRP CB   C  N N 394 
TRP CG   C  Y N 395 
TRP CD1  C  Y N 396 
TRP CD2  C  Y N 397 
TRP NE1  N  Y N 398 
TRP CE2  C  Y N 399 
TRP CE3  C  Y N 400 
TRP CZ2  C  Y N 401 
TRP CZ3  C  Y N 402 
TRP CH2  C  Y N 403 
TRP OXT  O  N N 404 
TRP H    H  N N 405 
TRP H2   H  N N 406 
TRP HA   H  N N 407 
TRP HB2  H  N N 408 
TRP HB3  H  N N 409 
TRP HD1  H  N N 410 
TRP HE1  H  N N 411 
TRP HE3  H  N N 412 
TRP HZ2  H  N N 413 
TRP HZ3  H  N N 414 
TRP HH2  H  N N 415 
TRP HXT  H  N N 416 
TYR N    N  N N 417 
TYR CA   C  N S 418 
TYR C    C  N N 419 
TYR O    O  N N 420 
TYR CB   C  N N 421 
TYR CG   C  Y N 422 
TYR CD1  C  Y N 423 
TYR CD2  C  Y N 424 
TYR CE1  C  Y N 425 
TYR CE2  C  Y N 426 
TYR CZ   C  Y N 427 
TYR OH   O  N N 428 
TYR OXT  O  N N 429 
TYR H    H  N N 430 
TYR H2   H  N N 431 
TYR HA   H  N N 432 
TYR HB2  H  N N 433 
TYR HB3  H  N N 434 
TYR HD1  H  N N 435 
TYR HD2  H  N N 436 
TYR HE1  H  N N 437 
TYR HE2  H  N N 438 
TYR HH   H  N N 439 
TYR HXT  H  N N 440 
VAL N    N  N N 441 
VAL CA   C  N S 442 
VAL C    C  N N 443 
VAL O    O  N N 444 
VAL CB   C  N N 445 
VAL CG1  C  N N 446 
VAL CG2  C  N N 447 
VAL OXT  O  N N 448 
VAL H    H  N N 449 
VAL H2   H  N N 450 
VAL HA   H  N N 451 
VAL HB   H  N N 452 
VAL HG11 H  N N 453 
VAL HG12 H  N N 454 
VAL HG13 H  N N 455 
VAL HG21 H  N N 456 
VAL HG22 H  N N 457 
VAL HG23 H  N N 458 
VAL HXT  H  N N 459 
ZN  ZN   ZN N N 460 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DOR O2  C2   doub N N 83  
DOR C2  N1   sing N N 84  
DOR C2  N3   sing N N 85  
DOR N1  C6   sing N N 86  
DOR N1  HN1  sing N N 87  
DOR N3  C4   sing N N 88  
DOR N3  HN3  sing N N 89  
DOR C4  O4   doub N N 90  
DOR C4  C5   sing N N 91  
DOR C5  C6   sing N N 92  
DOR C5  H51  sing N N 93  
DOR C5  H52  sing N N 94  
DOR C6  C7   sing N N 95  
DOR C6  H6   sing N N 96  
DOR C7  O72  sing N N 97  
DOR C7  O71  doub N N 98  
DOR O72 H72  sing N N 99  
FMT C   O1   doub N N 100 
FMT C   O2   sing N N 101 
FMT C   H    sing N N 102 
FMT O2  HO2  sing N N 103 
GLN N   CA   sing N N 104 
GLN N   H    sing N N 105 
GLN N   H2   sing N N 106 
GLN CA  C    sing N N 107 
GLN CA  CB   sing N N 108 
GLN CA  HA   sing N N 109 
GLN C   O    doub N N 110 
GLN C   OXT  sing N N 111 
GLN CB  CG   sing N N 112 
GLN CB  HB2  sing N N 113 
GLN CB  HB3  sing N N 114 
GLN CG  CD   sing N N 115 
GLN CG  HG2  sing N N 116 
GLN CG  HG3  sing N N 117 
GLN CD  OE1  doub N N 118 
GLN CD  NE2  sing N N 119 
GLN NE2 HE21 sing N N 120 
GLN NE2 HE22 sing N N 121 
GLN OXT HXT  sing N N 122 
GLU N   CA   sing N N 123 
GLU N   H    sing N N 124 
GLU N   H2   sing N N 125 
GLU CA  C    sing N N 126 
GLU CA  CB   sing N N 127 
GLU CA  HA   sing N N 128 
GLU C   O    doub N N 129 
GLU C   OXT  sing N N 130 
GLU CB  CG   sing N N 131 
GLU CB  HB2  sing N N 132 
GLU CB  HB3  sing N N 133 
GLU CG  CD   sing N N 134 
GLU CG  HG2  sing N N 135 
GLU CG  HG3  sing N N 136 
GLU CD  OE1  doub N N 137 
GLU CD  OE2  sing N N 138 
GLU OE2 HE2  sing N N 139 
GLU OXT HXT  sing N N 140 
GLY N   CA   sing N N 141 
GLY N   H    sing N N 142 
GLY N   H2   sing N N 143 
GLY CA  C    sing N N 144 
GLY CA  HA2  sing N N 145 
GLY CA  HA3  sing N N 146 
GLY C   O    doub N N 147 
GLY C   OXT  sing N N 148 
GLY OXT HXT  sing N N 149 
HIS N   CA   sing N N 150 
HIS N   H    sing N N 151 
HIS N   H2   sing N N 152 
HIS CA  C    sing N N 153 
HIS CA  CB   sing N N 154 
HIS CA  HA   sing N N 155 
HIS C   O    doub N N 156 
HIS C   OXT  sing N N 157 
HIS CB  CG   sing N N 158 
HIS CB  HB2  sing N N 159 
HIS CB  HB3  sing N N 160 
HIS CG  ND1  sing Y N 161 
HIS CG  CD2  doub Y N 162 
HIS ND1 CE1  doub Y N 163 
HIS ND1 HD1  sing N N 164 
HIS CD2 NE2  sing Y N 165 
HIS CD2 HD2  sing N N 166 
HIS CE1 NE2  sing Y N 167 
HIS CE1 HE1  sing N N 168 
HIS NE2 HE2  sing N N 169 
HIS OXT HXT  sing N N 170 
HOH O   H1   sing N N 171 
HOH O   H2   sing N N 172 
ILE N   CA   sing N N 173 
ILE N   H    sing N N 174 
ILE N   H2   sing N N 175 
ILE CA  C    sing N N 176 
ILE CA  CB   sing N N 177 
ILE CA  HA   sing N N 178 
ILE C   O    doub N N 179 
ILE C   OXT  sing N N 180 
ILE CB  CG1  sing N N 181 
ILE CB  CG2  sing N N 182 
ILE CB  HB   sing N N 183 
ILE CG1 CD1  sing N N 184 
ILE CG1 HG12 sing N N 185 
ILE CG1 HG13 sing N N 186 
ILE CG2 HG21 sing N N 187 
ILE CG2 HG22 sing N N 188 
ILE CG2 HG23 sing N N 189 
ILE CD1 HD11 sing N N 190 
ILE CD1 HD12 sing N N 191 
ILE CD1 HD13 sing N N 192 
ILE OXT HXT  sing N N 193 
KCX N   CA   sing N N 194 
KCX N   H    sing N N 195 
KCX N   H2   sing N N 196 
KCX CA  CB   sing N N 197 
KCX CA  C    sing N N 198 
KCX CA  HA   sing N N 199 
KCX CB  CG   sing N N 200 
KCX CB  HB2  sing N N 201 
KCX CB  HB3  sing N N 202 
KCX CG  CD   sing N N 203 
KCX CG  HG2  sing N N 204 
KCX CG  HG3  sing N N 205 
KCX CD  CE   sing N N 206 
KCX CD  HD2  sing N N 207 
KCX CD  HD3  sing N N 208 
KCX CE  NZ   sing N N 209 
KCX CE  HE2  sing N N 210 
KCX CE  HE3  sing N N 211 
KCX NZ  CX   sing N N 212 
KCX NZ  HZ   sing N N 213 
KCX C   O    doub N N 214 
KCX C   OXT  sing N N 215 
KCX CX  OQ1  doub N N 216 
KCX CX  OQ2  sing N N 217 
KCX OXT HXT  sing N N 218 
KCX OQ2 HQ2  sing N N 219 
LEU N   CA   sing N N 220 
LEU N   H    sing N N 221 
LEU N   H2   sing N N 222 
LEU CA  C    sing N N 223 
LEU CA  CB   sing N N 224 
LEU CA  HA   sing N N 225 
LEU C   O    doub N N 226 
LEU C   OXT  sing N N 227 
LEU CB  CG   sing N N 228 
LEU CB  HB2  sing N N 229 
LEU CB  HB3  sing N N 230 
LEU CG  CD1  sing N N 231 
LEU CG  CD2  sing N N 232 
LEU CG  HG   sing N N 233 
LEU CD1 HD11 sing N N 234 
LEU CD1 HD12 sing N N 235 
LEU CD1 HD13 sing N N 236 
LEU CD2 HD21 sing N N 237 
LEU CD2 HD22 sing N N 238 
LEU CD2 HD23 sing N N 239 
LEU OXT HXT  sing N N 240 
LYS N   CA   sing N N 241 
LYS N   H    sing N N 242 
LYS N   H2   sing N N 243 
LYS CA  C    sing N N 244 
LYS CA  CB   sing N N 245 
LYS CA  HA   sing N N 246 
LYS C   O    doub N N 247 
LYS C   OXT  sing N N 248 
LYS CB  CG   sing N N 249 
LYS CB  HB2  sing N N 250 
LYS CB  HB3  sing N N 251 
LYS CG  CD   sing N N 252 
LYS CG  HG2  sing N N 253 
LYS CG  HG3  sing N N 254 
LYS CD  CE   sing N N 255 
LYS CD  HD2  sing N N 256 
LYS CD  HD3  sing N N 257 
LYS CE  NZ   sing N N 258 
LYS CE  HE2  sing N N 259 
LYS CE  HE3  sing N N 260 
LYS NZ  HZ1  sing N N 261 
LYS NZ  HZ2  sing N N 262 
LYS NZ  HZ3  sing N N 263 
LYS OXT HXT  sing N N 264 
MET N   CA   sing N N 265 
MET N   H    sing N N 266 
MET N   H2   sing N N 267 
MET CA  C    sing N N 268 
MET CA  CB   sing N N 269 
MET CA  HA   sing N N 270 
MET C   O    doub N N 271 
MET C   OXT  sing N N 272 
MET CB  CG   sing N N 273 
MET CB  HB2  sing N N 274 
MET CB  HB3  sing N N 275 
MET CG  SD   sing N N 276 
MET CG  HG2  sing N N 277 
MET CG  HG3  sing N N 278 
MET SD  CE   sing N N 279 
MET CE  HE1  sing N N 280 
MET CE  HE2  sing N N 281 
MET CE  HE3  sing N N 282 
MET OXT HXT  sing N N 283 
NCD C6  C61  sing N N 284 
NCD C6  N1   sing N N 285 
NCD C6  C5   sing N N 286 
NCD C6  H61  sing N N 287 
NCD C61 O61  sing N N 288 
NCD C61 O62  doub N N 289 
NCD O61 H611 sing N N 290 
NCD N1  C2   sing N N 291 
NCD N1  H11  sing N N 292 
NCD C2  O2   doub N N 293 
NCD C2  N3   sing N N 294 
NCD N3  H31  sing N N 295 
NCD N3  H32  sing N N 296 
NCD C5  C4   sing N N 297 
NCD C5  H51  sing N N 298 
NCD C5  H52  sing N N 299 
NCD C4  O4   doub N N 300 
NCD C4  O5   sing N N 301 
NCD O5  HO51 sing N N 302 
PHE N   CA   sing N N 303 
PHE N   H    sing N N 304 
PHE N   H2   sing N N 305 
PHE CA  C    sing N N 306 
PHE CA  CB   sing N N 307 
PHE CA  HA   sing N N 308 
PHE C   O    doub N N 309 
PHE C   OXT  sing N N 310 
PHE CB  CG   sing N N 311 
PHE CB  HB2  sing N N 312 
PHE CB  HB3  sing N N 313 
PHE CG  CD1  doub Y N 314 
PHE CG  CD2  sing Y N 315 
PHE CD1 CE1  sing Y N 316 
PHE CD1 HD1  sing N N 317 
PHE CD2 CE2  doub Y N 318 
PHE CD2 HD2  sing N N 319 
PHE CE1 CZ   doub Y N 320 
PHE CE1 HE1  sing N N 321 
PHE CE2 CZ   sing Y N 322 
PHE CE2 HE2  sing N N 323 
PHE CZ  HZ   sing N N 324 
PHE OXT HXT  sing N N 325 
PRO N   CA   sing N N 326 
PRO N   CD   sing N N 327 
PRO N   H    sing N N 328 
PRO CA  C    sing N N 329 
PRO CA  CB   sing N N 330 
PRO CA  HA   sing N N 331 
PRO C   O    doub N N 332 
PRO C   OXT  sing N N 333 
PRO CB  CG   sing N N 334 
PRO CB  HB2  sing N N 335 
PRO CB  HB3  sing N N 336 
PRO CG  CD   sing N N 337 
PRO CG  HG2  sing N N 338 
PRO CG  HG3  sing N N 339 
PRO CD  HD2  sing N N 340 
PRO CD  HD3  sing N N 341 
PRO OXT HXT  sing N N 342 
SER N   CA   sing N N 343 
SER N   H    sing N N 344 
SER N   H2   sing N N 345 
SER CA  C    sing N N 346 
SER CA  CB   sing N N 347 
SER CA  HA   sing N N 348 
SER C   O    doub N N 349 
SER C   OXT  sing N N 350 
SER CB  OG   sing N N 351 
SER CB  HB2  sing N N 352 
SER CB  HB3  sing N N 353 
SER OG  HG   sing N N 354 
SER OXT HXT  sing N N 355 
THR N   CA   sing N N 356 
THR N   H    sing N N 357 
THR N   H2   sing N N 358 
THR CA  C    sing N N 359 
THR CA  CB   sing N N 360 
THR CA  HA   sing N N 361 
THR C   O    doub N N 362 
THR C   OXT  sing N N 363 
THR CB  OG1  sing N N 364 
THR CB  CG2  sing N N 365 
THR CB  HB   sing N N 366 
THR OG1 HG1  sing N N 367 
THR CG2 HG21 sing N N 368 
THR CG2 HG22 sing N N 369 
THR CG2 HG23 sing N N 370 
THR OXT HXT  sing N N 371 
TRP N   CA   sing N N 372 
TRP N   H    sing N N 373 
TRP N   H2   sing N N 374 
TRP CA  C    sing N N 375 
TRP CA  CB   sing N N 376 
TRP CA  HA   sing N N 377 
TRP C   O    doub N N 378 
TRP C   OXT  sing N N 379 
TRP CB  CG   sing N N 380 
TRP CB  HB2  sing N N 381 
TRP CB  HB3  sing N N 382 
TRP CG  CD1  doub Y N 383 
TRP CG  CD2  sing Y N 384 
TRP CD1 NE1  sing Y N 385 
TRP CD1 HD1  sing N N 386 
TRP CD2 CE2  doub Y N 387 
TRP CD2 CE3  sing Y N 388 
TRP NE1 CE2  sing Y N 389 
TRP NE1 HE1  sing N N 390 
TRP CE2 CZ2  sing Y N 391 
TRP CE3 CZ3  doub Y N 392 
TRP CE3 HE3  sing N N 393 
TRP CZ2 CH2  doub Y N 394 
TRP CZ2 HZ2  sing N N 395 
TRP CZ3 CH2  sing Y N 396 
TRP CZ3 HZ3  sing N N 397 
TRP CH2 HH2  sing N N 398 
TRP OXT HXT  sing N N 399 
TYR N   CA   sing N N 400 
TYR N   H    sing N N 401 
TYR N   H2   sing N N 402 
TYR CA  C    sing N N 403 
TYR CA  CB   sing N N 404 
TYR CA  HA   sing N N 405 
TYR C   O    doub N N 406 
TYR C   OXT  sing N N 407 
TYR CB  CG   sing N N 408 
TYR CB  HB2  sing N N 409 
TYR CB  HB3  sing N N 410 
TYR CG  CD1  doub Y N 411 
TYR CG  CD2  sing Y N 412 
TYR CD1 CE1  sing Y N 413 
TYR CD1 HD1  sing N N 414 
TYR CD2 CE2  doub Y N 415 
TYR CD2 HD2  sing N N 416 
TYR CE1 CZ   doub Y N 417 
TYR CE1 HE1  sing N N 418 
TYR CE2 CZ   sing Y N 419 
TYR CE2 HE2  sing N N 420 
TYR CZ  OH   sing N N 421 
TYR OH  HH   sing N N 422 
TYR OXT HXT  sing N N 423 
VAL N   CA   sing N N 424 
VAL N   H    sing N N 425 
VAL N   H2   sing N N 426 
VAL CA  C    sing N N 427 
VAL CA  CB   sing N N 428 
VAL CA  HA   sing N N 429 
VAL C   O    doub N N 430 
VAL C   OXT  sing N N 431 
VAL CB  CG1  sing N N 432 
VAL CB  CG2  sing N N 433 
VAL CB  HB   sing N N 434 
VAL CG1 HG11 sing N N 435 
VAL CG1 HG12 sing N N 436 
VAL CG1 HG13 sing N N 437 
VAL CG2 HG21 sing N N 438 
VAL CG2 HG22 sing N N 439 
VAL CG2 HG23 sing N N 440 
VAL OXT HXT  sing N N 441 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministerio de Ciencia e Innovacion (MCIN)' Spain PID2021-128468NB-I00     1 
'Other private'                             ?     'Fundacion Ramon Areces' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   1 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4C6I 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 2 2 21' 
_space_group.name_Hall        'C 2c 2' 
_space_group.IT_number        20 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FS2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012174 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006306 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016142 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345  0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . LYS A 1 1   ? -12.54801 -31.49980 -38.72816 1.000 33.28266 ? 1460 LYS A N    1 
ATOM   2    C  CA   . LYS A 1 1   ? -11.29335 -31.37375 -37.99407 1.000 32.46683 ? 1460 LYS A CA   1 
ATOM   3    C  C    . LYS A 1 1   ? -11.52971 -30.75198 -36.60250 1.000 31.46404 ? 1460 LYS A C    1 
ATOM   4    O  O    . LYS A 1 1   ? -11.88950 -29.58360 -36.47330 1.000 34.77223 ? 1460 LYS A O    1 
ATOM   5    C  CB   . LYS A 1 1   ? -10.31077 -30.50414 -38.77234 1.000 33.66953 ? 1460 LYS A CB   1 
ATOM   6    H  HA   . LYS A 1 1   ? -10.90670 -32.25579 -37.87824 1.000 38.96020 ? 1460 LYS A HA   1 
ATOM   7    N  N    . LEU A 1 2   ? -11.31760 -31.55807 -35.56797 1.000 26.47669 ? 1461 LEU A N    1 
ATOM   8    C  CA   . LEU A 1 2   ? -11.55580 -31.14827 -34.19677 1.000 24.09478 ? 1461 LEU A CA   1 
ATOM   9    C  C    . LEU A 1 2   ? -10.29471 -30.52282 -33.62831 1.000 21.66817 ? 1461 LEU A C    1 
ATOM   10   O  O    . LEU A 1 2   ? -9.17840  -30.84646 -34.04744 1.000 24.84732 ? 1461 LEU A O    1 
ATOM   11   C  CB   . LEU A 1 2   ? -11.94811 -32.37328 -33.36131 1.000 24.95014 ? 1461 LEU A CB   1 
ATOM   12   C  CG   . LEU A 1 2   ? -13.19482 -33.13365 -33.82568 1.000 25.33966 ? 1461 LEU A CG   1 
ATOM   13   C  CD1  . LEU A 1 2   ? -13.66887 -34.14352 -32.77351 1.000 27.38192 ? 1461 LEU A CD1  1 
ATOM   14   C  CD2  . LEU A 1 2   ? -14.34238 -32.15834 -34.14342 1.000 24.14216 ? 1461 LEU A CD2  1 
ATOM   15   H  H    . LEU A 1 2   ? -11.02915 -32.36508 -35.63967 1.000 31.77203 ? 1461 LEU A H    1 
ATOM   16   H  HA   . LEU A 1 2   ? -12.27209 -30.49574 -34.15169 1.000 28.91374 ? 1461 LEU A HA   1 
ATOM   17   H  HB2  . LEU A 1 2   ? -11.20756 -32.99956 -33.37717 1.000 29.94017 ? 1461 LEU A HB2  1 
ATOM   18   H  HB3  . LEU A 1 2   ? -12.11387 -32.07847 -32.45218 1.000 29.94017 ? 1461 LEU A HB3  1 
ATOM   19   H  HG   . LEU A 1 2   ? -12.95660 -33.62109 -34.62976 1.000 30.40759 ? 1461 LEU A HG   1 
ATOM   20   H  HD11 . LEU A 1 2   ? -14.46094 -34.59555 -33.10396 1.000 32.85830 ? 1461 LEU A HD11 1 
ATOM   21   H  HD12 . LEU A 1 2   ? -12.96222 -34.78857 -32.61399 1.000 32.85830 ? 1461 LEU A HD12 1 
ATOM   22   H  HD13 . LEU A 1 2   ? -13.87632 -33.67035 -31.95255 1.000 32.85830 ? 1461 LEU A HD13 1 
ATOM   23   H  HD21 . LEU A 1 2   ? -15.11999 -32.66612 -34.42339 1.000 28.97060 ? 1461 LEU A HD21 1 
ATOM   24   H  HD22 . LEU A 1 2   ? -14.55116 -31.64604 -33.34665 1.000 28.97060 ? 1461 LEU A HD22 1 
ATOM   25   H  HD23 . LEU A 1 2   ? -14.06234 -31.56254 -34.85581 1.000 28.97060 ? 1461 LEU A HD23 1 
ATOM   26   N  N    . VAL A 1 3   ? -10.46889 -29.61227 -32.71302 1.000 17.77044 ? 1462 VAL A N    1 
ATOM   27   C  CA   . VAL A 1 3   ? -9.37277  -28.98614 -31.98276 1.000 17.30979 ? 1462 VAL A CA   1 
ATOM   28   C  C    . VAL A 1 3   ? -9.31632  -29.58815 -30.59717 1.000 16.21224 ? 1462 VAL A C    1 
ATOM   29   O  O    . VAL A 1 3   ? -10.33206 -29.66144 -29.90930 1.000 15.31218 ? 1462 VAL A O    1 
ATOM   30   C  CB   . VAL A 1 3   ? -9.53197  -27.45949 -31.92977 1.000 19.79167 ? 1462 VAL A CB   1 
ATOM   31   C  CG1  . VAL A 1 3   ? -8.35678  -26.81186 -31.23133 1.000 21.95759 ? 1462 VAL A CG1  1 
ATOM   32   C  CG2  . VAL A 1 3   ? -9.69017  -26.91391 -33.33364 1.000 21.95756 ? 1462 VAL A CG2  1 
ATOM   33   H  H    . VAL A 1 3   ? -11.24200 -29.31851 -32.47720 1.000 21.32452 ? 1462 VAL A H    1 
ATOM   34   H  HA   . VAL A 1 3   ? -8.53453  -29.18024 -32.43062 1.000 20.77175 ? 1462 VAL A HA   1 
ATOM   35   H  HB   . VAL A 1 3   ? -10.32685 -27.24210 -31.41810 1.000 23.75001 ? 1462 VAL A HB   1 
ATOM   36   H  HG11 . VAL A 1 3   ? -8.42214  -25.84912 -31.33008 1.000 26.34911 ? 1462 VAL A HG11 1 
ATOM   37   H  HG12 . VAL A 1 3   ? -8.37767  -27.05012 -30.29128 1.000 26.34911 ? 1462 VAL A HG12 1 
ATOM   38   H  HG13 . VAL A 1 3   ? -7.53453  -27.13074 -31.63519 1.000 26.34911 ? 1462 VAL A HG13 1 
ATOM   39   H  HG21 . VAL A 1 3   ? -9.69488  -25.94461 -33.29710 1.000 26.34907 ? 1462 VAL A HG21 1 
ATOM   40   H  HG22 . VAL A 1 3   ? -8.94775  -27.22083 -33.87726 1.000 26.34907 ? 1462 VAL A HG22 1 
ATOM   41   H  HG23 . VAL A 1 3   ? -10.52686 -27.23500 -33.70481 1.000 26.34907 ? 1462 VAL A HG23 1 
ATOM   42   N  N    . ARG A 1 4   ? -8.12862  -30.01952 -30.19403 1.000 15.40163 ? 1463 ARG A N    1 
ATOM   43   C  CA   . ARG A 1 4   ? -7.86755  -30.59444 -28.87776 1.000 15.57008 ? 1463 ARG A CA   1 
ATOM   44   C  C    . ARG A 1 4   ? -7.46072  -29.48979 -27.91638 1.000 15.21219 ? 1463 ARG A C    1 
ATOM   45   O  O    . ARG A 1 4   ? -6.43843  -28.78375 -28.14258 1.000 18.41760 ? 1463 ARG A O    1 
ATOM   46   C  CB   . ARG A 1 4   ? -6.73562  -31.62871 -28.97848 1.000 17.17286 ? 1463 ARG A CB   1 
ATOM   47   C  CG   . ARG A 1 4   ? -6.38303  -32.20945 -27.61310 1.000 19.14939 ? 1463 ARG A CG   1 
ATOM   48   C  CD   . ARG A 1 4   ? -5.27675  -33.26241 -27.73629 1.000 20.33640 ? 1463 ARG A CD   1 
ATOM   49   N  NE   . ARG A 1 4   ? -4.72260  -33.66910 -26.44777 1.000 20.88650 ? 1463 ARG A NE   1 
ATOM   50   C  CZ   . ARG A 1 4   ? -4.44566  -34.91427 -26.09993 1.000 22.26820 ? 1463 ARG A CZ   1 
ATOM   51   N  NH1  . ARG A 1 4   ? -4.71951  -35.94065 -26.90404 1.000 24.82895 ? 1463 ARG A NH1  1 
ATOM   52   N  NH2  . ARG A 1 4   ? -3.87381  -35.13976 -24.91783 1.000 21.32602 ? 1463 ARG A NH2  1 
ATOM   53   H  H    . ARG A 1 4   ? -7.42401  -29.98942 -30.68620 1.000 18.48195 ? 1463 ARG A H    1 
ATOM   54   H  HA   . ARG A 1 4   ? -8.67237  -31.02077 -28.54397 1.000 18.68410 ? 1463 ARG A HA   1 
ATOM   55   H  HB2  . ARG A 1 4   ? -7.01655  -32.35556 -29.55612 1.000 20.60743 ? 1463 ARG A HB2  1 
ATOM   56   H  HB3  . ARG A 1 4   ? -5.94401  -31.20252 -29.34266 1.000 20.60743 ? 1463 ARG A HB3  1 
ATOM   57   H  HG2  . ARG A 1 4   ? -6.06872  -31.50000 -27.03105 1.000 22.97927 ? 1463 ARG A HG2  1 
ATOM   58   H  HG3  . ARG A 1 4   ? -7.16733  -32.63115 -27.22847 1.000 22.97927 ? 1463 ARG A HG3  1 
ATOM   59   H  HD2  . ARG A 1 4   ? -5.64062  -34.05200 -28.16647 1.000 24.40368 ? 1463 ARG A HD2  1 
ATOM   60   H  HD3  . ARG A 1 4   ? -4.55337  -32.89760 -28.26971 1.000 24.40368 ? 1463 ARG A HD3  1 
ATOM   61   H  HE   . ARG A 1 4   ? -4.56424  -33.05122 -25.87093 1.000 25.06380 ? 1463 ARG A HE   1 
ATOM   62   H  HH11 . ARG A 1 4   ? -5.08512  -35.80129 -27.66988 1.000 29.79475 ? 1463 ARG A HH11 1 
ATOM   63   H  HH12 . ARG A 1 4   ? -4.53068  -36.74255 -26.65724 1.000 29.79475 ? 1463 ARG A HH12 1 
ATOM   64   H  HH21 . ARG A 1 4   ? -3.69121  -34.48111 -24.39587 1.000 25.59122 ? 1463 ARG A HH21 1 
ATOM   65   H  HH22 . ARG A 1 4   ? -3.68732  -35.94394 -24.67679 1.000 25.59122 ? 1463 ARG A HH22 1 
ATOM   66   N  N    . LEU A 1 5   ? -8.21188  -29.31859 -26.89408 1.000 13.18035 ? 1464 LEU A N    1 
ATOM   67   C  CA   . LEU A 1 5   ? -7.97580  -28.42300 -25.77714 1.000 11.92491 ? 1464 LEU A CA   1 
ATOM   68   C  C    . LEU A 1 5   ? -7.59788  -29.22506 -24.54423 1.000 11.66693 ? 1464 LEU A C    1 
ATOM   69   O  O    . LEU A 1 5   ? -7.99272  -30.40263 -24.42083 1.000 12.62233 ? 1464 LEU A O    1 
ATOM   70   C  CB   . LEU A 1 5   ? -9.24155  -27.63650 -25.44662 1.000 12.23031 ? 1464 LEU A CB   1 
ATOM   71   C  CG   . LEU A 1 5   ? -9.92117  -26.92773 -26.61081 1.000 14.92783 ? 1464 LEU A CG   1 
ATOM   72   C  CD1  . LEU A 1 5   ? -11.15892 -26.20582 -26.07607 1.000 14.95679 ? 1464 LEU A CD1  1 
ATOM   73   C  CD2  . LEU A 1 5   ? -8.97870  -26.00936 -27.38059 1.000 17.29912 ? 1464 LEU A CD2  1 
ATOM   74   H  H    . LEU A 1 5   ? -8.95086  -29.74636 -26.79152 1.000 15.81642 ? 1464 LEU A H    1 
ATOM   75   H  HA   . LEU A 1 5   ? -7.26218  -27.80405 -25.99745 1.000 14.30989 ? 1464 LEU A HA   1 
ATOM   76   H  HB2  . LEU A 1 5   ? -9.88913  -28.25285 -25.07025 1.000 14.67637 ? 1464 LEU A HB2  1 
ATOM   77   H  HB3  . LEU A 1 5   ? -9.01172  -26.95707 -24.79358 1.000 14.67637 ? 1464 LEU A HB3  1 
ATOM   78   H  HG   . LEU A 1 5   ? -10.20051 -27.57776 -27.27439 1.000 17.91340 ? 1464 LEU A HG   1 
ATOM   79   H  HD11 . LEU A 1 5   ? -11.59602 -25.74374 -26.80841 1.000 17.94815 ? 1464 LEU A HD11 1 
ATOM   80   H  HD12 . LEU A 1 5   ? -11.76301 -26.85889 -25.68947 1.000 17.94815 ? 1464 LEU A HD12 1 
ATOM   81   H  HD13 . LEU A 1 5   ? -10.88445 -25.56765 -25.39909 1.000 17.94815 ? 1464 LEU A HD13 1 
ATOM   82   H  HD21 . LEU A 1 5   ? -9.48241  -25.54217 -28.06537 1.000 20.75895 ? 1464 LEU A HD21 1 
ATOM   83   H  HD22 . LEU A 1 5   ? -8.58696  -25.37072 -26.76449 1.000 20.75895 ? 1464 LEU A HD22 1 
ATOM   84   H  HD23 . LEU A 1 5   ? -8.28106  -26.54447 -27.79029 1.000 20.75895 ? 1464 LEU A HD23 1 
ATOM   85   N  N    . PRO A 1 6   ? -6.85229  -28.64430 -23.62354 1.000 12.32497 ? 1465 PRO A N    1 
ATOM   86   C  CA   . PRO A 1 6   ? -6.62978  -29.28886 -22.32538 1.000 12.44076 ? 1465 PRO A CA   1 
ATOM   87   C  C    . PRO A 1 6   ? -7.91009  -29.30089 -21.51271 1.000 12.55659 ? 1465 PRO A C    1 
ATOM   88   O  O    . PRO A 1 6   ? -8.92594  -28.71760 -21.88833 1.000 13.04866 ? 1465 PRO A O    1 
ATOM   89   C  CB   . PRO A 1 6   ? -5.55318  -28.40917 -21.66022 1.000 14.23562 ? 1465 PRO A CB   1 
ATOM   90   C  CG   . PRO A 1 6   ? -5.87685  -27.05857 -22.21837 1.000 15.06196 ? 1465 PRO A CG   1 
ATOM   91   C  CD   . PRO A 1 6   ? -6.30373  -27.26809 -23.65161 1.000 13.24349 ? 1465 PRO A CD   1 
ATOM   92   H  HA   . PRO A 1 6   ? -6.28867  -30.19047 -22.43330 1.000 14.92891 ? 1465 PRO A HA   1 
ATOM   93   H  HB2  . PRO A 1 6   ? -5.64197  -28.42920 -20.69450 1.000 17.08275 ? 1465 PRO A HB2  1 
ATOM   94   H  HB3  . PRO A 1 6   ? -4.66453  -28.70049 -21.91779 1.000 17.08275 ? 1465 PRO A HB3  1 
ATOM   95   H  HG2  . PRO A 1 6   ? -6.59655  -26.66049 -21.70412 1.000 18.07435 ? 1465 PRO A HG2  1 
ATOM   96   H  HG3  . PRO A 1 6   ? -5.08862  -26.49473 -22.17748 1.000 18.07435 ? 1465 PRO A HG3  1 
ATOM   97   H  HD2  . PRO A 1 6   ? -6.98428  -26.62692 -23.90977 1.000 15.89219 ? 1465 PRO A HD2  1 
ATOM   98   H  HD3  . PRO A 1 6   ? -5.54544  -27.20745 -24.25346 1.000 15.89219 ? 1465 PRO A HD3  1 
ATOM   99   N  N    . GLY A 1 7   ? -7.86457  -29.98628 -20.37148 1.000 12.78285 ? 1466 GLY A N    1 
ATOM   100  C  CA   . GLY A 1 7   ? -9.00519  -30.01537 -19.47494 1.000 12.40122 ? 1466 GLY A CA   1 
ATOM   101  C  C    . GLY A 1 7   ? -9.25103  -28.64377 -18.86181 1.000 10.89582 ? 1466 GLY A C    1 
ATOM   102  O  O    . GLY A 1 7   ? -8.40817  -28.13761 -18.10581 1.000 11.51430 ? 1466 GLY A O    1 
ATOM   103  H  H    . GLY A 1 7   ? -7.18613  -30.43905 -20.09888 1.000 15.33942 ? 1466 GLY A H    1 
ATOM   104  H  HA2  . GLY A 1 7   ? -9.79859  -30.28460 -19.96375 1.000 14.88147 ? 1466 GLY A HA2  1 
ATOM   105  H  HA3  . GLY A 1 7   ? -8.84347  -30.65126 -18.76052 1.000 14.88147 ? 1466 GLY A HA3  1 
ATOM   106  N  N    . LEU A 1 8   ? -10.40254 -28.05732 -19.13330 1.000 10.21944 ? 1467 LEU A N    1 
ATOM   107  C  CA   . LEU A 1 8   ? -10.67711 -26.70639 -18.64637 1.000 10.20359 ? 1467 LEU A CA   1 
ATOM   108  C  C    . LEU A 1 8   ? -11.18148 -26.72335 -17.20812 1.000 10.01941 ? 1467 LEU A C    1 
ATOM   109  O  O    . LEU A 1 8   ? -11.78406 -27.69405 -16.72044 1.000 10.86154 ? 1467 LEU A O    1 
ATOM   110  C  CB   . LEU A 1 8   ? -11.64789 -26.01525 -19.61402 1.000 9.81151  ? 1467 LEU A CB   1 
ATOM   111  C  CG   . LEU A 1 8   ? -11.28158 -26.01250 -21.06391 1.000 10.81946 ? 1467 LEU A CG   1 
ATOM   112  C  CD1  . LEU A 1 8   ? -12.34198 -25.28169 -21.90979 1.000 11.92215 ? 1467 LEU A CD1  1 
ATOM   113  C  CD2  . LEU A 1 8   ? -9.89139  -25.41079 -21.32159 1.000 10.80107 ? 1467 LEU A CD2  1 
ATOM   114  H  H    . LEU A 1 8   ? -11.03827 -28.41115 -19.59183 1.000 12.26332 ? 1467 LEU A H    1 
ATOM   115  H  HA   . LEU A 1 8   ? -9.86682  -26.17384 -18.61951 1.000 12.24430 ? 1467 LEU A HA   1 
ATOM   116  H  HB2  . LEU A 1 8   ? -12.50728 -26.45913 -19.54110 1.000 11.77381 ? 1467 LEU A HB2  1 
ATOM   117  H  HB3  . LEU A 1 8   ? -11.72941 -25.08775 -19.34198 1.000 11.77381 ? 1467 LEU A HB3  1 
ATOM   118  H  HG   . LEU A 1 8   ? -11.24839 -26.94001 -21.34592 1.000 12.98335 ? 1467 LEU A HG   1 
ATOM   119  H  HD11 . LEU A 1 8   ? -12.07674 -25.31045 -22.84238 1.000 14.30659 ? 1467 LEU A HD11 1 
ATOM   120  H  HD12 . LEU A 1 8   ? -13.19735 -25.72456 -21.79536 1.000 14.30659 ? 1467 LEU A HD12 1 
ATOM   121  H  HD13 . LEU A 1 8   ? -12.40386 -24.36069 -21.61175 1.000 14.30659 ? 1467 LEU A HD13 1 
ATOM   122  H  HD21 . LEU A 1 8   ? -9.73663  -25.37162 -22.27837 1.000 12.96129 ? 1467 LEU A HD21 1 
ATOM   123  H  HD22 . LEU A 1 8   ? -9.85898  -24.51770 -20.94444 1.000 12.96129 ? 1467 LEU A HD22 1 
ATOM   124  H  HD23 . LEU A 1 8   ? -9.22141  -25.97205 -20.90086 1.000 12.96129 ? 1467 LEU A HD23 1 
ATOM   125  N  N    . ILE A 1 9   ? -10.93133 -25.60883 -16.52361 1.000 9.41144  ? 1468 ILE A N    1 
ATOM   126  C  CA   . ILE A 1 9   ? -11.15104 -25.46925 -15.10369 1.000 9.39037  ? 1468 ILE A CA   1 
ATOM   127  C  C    . ILE A 1 9   ? -12.06859 -24.28489 -14.89368 1.000 9.62988  ? 1468 ILE A C    1 
ATOM   128  O  O    . ILE A 1 9   ? -11.77302 -23.17921 -15.35121 1.000 10.09566 ? 1468 ILE A O    1 
ATOM   129  C  CB   . ILE A 1 9   ? -9.81944  -25.24999 -14.34914 1.000 9.87729  ? 1468 ILE A CB   1 
ATOM   130  C  CG1  . ILE A 1 9   ? -8.79708  -26.36923 -14.59788 1.000 10.42734 ? 1468 ILE A CG1  1 
ATOM   131  C  CG2  . ILE A 1 9   ? -10.10841 -25.01369 -12.88578 1.000 10.40359 ? 1468 ILE A CG2  1 
ATOM   132  C  CD1  . ILE A 1 9   ? -7.40084  -26.01644 -14.07764 1.000 12.18798 ? 1468 ILE A CD1  1 
ATOM   133  H  H    . ILE A 1 9   ? -10.62002 -24.89310 -16.88474 1.000 11.29372 ? 1468 ILE A H    1 
ATOM   134  H  HA   . ILE A 1 9   ? -11.57925 -26.26845 -14.75901 1.000 11.26845 ? 1468 ILE A HA   1 
ATOM   135  H  HB   . ILE A 1 9   ? -9.39103  -24.45653 -14.70658 1.000 11.85275 ? 1468 ILE A HB   1 
ATOM   136  H  HG12 . ILE A 1 9   ? -9.09269  -27.17427 -14.14464 1.000 12.51281 ? 1468 ILE A HG12 1 
ATOM   137  H  HG13 . ILE A 1 9   ? -8.73085  -26.53098 -15.55200 1.000 12.51281 ? 1468 ILE A HG13 1 
ATOM   138  H  HG21 . ILE A 1 9   ? -9.28462  -25.10673 -12.38217 1.000 12.48431 ? 1468 ILE A HG21 1 
ATOM   139  H  HG22 . ILE A 1 9   ? -10.46462 -24.11832 -12.77479 1.000 12.48431 ? 1468 ILE A HG22 1 
ATOM   140  H  HG23 . ILE A 1 9   ? -10.75726 -25.66778 -12.58237 1.000 12.48431 ? 1468 ILE A HG23 1 
ATOM   141  H  HD11 . ILE A 1 9   ? -6.76214  -26.65691 -14.42802 1.000 14.62558 ? 1468 ILE A HD11 1 
ATOM   142  H  HD12 . ILE A 1 9   ? -7.16970  -25.12245 -14.37473 1.000 14.62558 ? 1468 ILE A HD12 1 
ATOM   143  H  HD13 . ILE A 1 9   ? -7.40678  -26.05168 -13.10830 1.000 14.62558 ? 1468 ILE A HD13 1 
ATOM   144  N  N    . ASP A 1 10  ? -13.15753 -24.50544 -14.12904 1.000 8.91663  ? 1469 ASP A N    1 
ATOM   145  C  CA   . ASP A 1 10  ? -14.06872 -23.44369 -13.70675 1.000 8.98241  ? 1469 ASP A CA   1 
ATOM   146  C  C    . ASP A 1 10  ? -13.94073 -23.24004 -12.21424 1.000 9.16662  ? 1469 ASP A C    1 
ATOM   147  O  O    . ASP A 1 10  ? -14.36071 -24.07632 -11.40813 1.000 9.33770  ? 1469 ASP A O    1 
ATOM   148  C  CB   . ASP A 1 10  ? -15.50509 -23.77399 -14.13939 1.000 8.28762  ? 1469 ASP A CB   1 
ATOM   149  C  CG   . ASP A 1 10  ? -16.44099 -22.57883 -13.96803 1.000 9.00879  ? 1469 ASP A CG   1 
ATOM   150  O  OD1  . ASP A 1 10  ? -16.10953 -21.64575 -13.18385 1.000 9.72722  ? 1469 ASP A OD1  1 
ATOM   151  O  OD2  . ASP A 1 10  ? -17.49876 -22.60598 -14.64536 1.000 11.50366 ? 1469 ASP A OD2  1 
ATOM   152  H  H    . ASP A 1 10  ? -13.38622 -25.28277 -13.84085 1.000 10.69996 ? 1469 ASP A H    1 
ATOM   153  H  HA   . ASP A 1 10  ? -13.81271 -22.60522 -14.12187 1.000 10.77890 ? 1469 ASP A HA   1 
ATOM   154  H  HB2  . ASP A 1 10  ? -15.50615 -24.02861 -15.07537 1.000 9.94514  ? 1469 ASP A HB2  1 
ATOM   155  H  HB3  . ASP A 1 10  ? -15.84226 -24.50382 -13.59665 1.000 9.94514  ? 1469 ASP A HB3  1 
ATOM   156  N  N    . VAL A 1 11  ? -13.32480 -22.10678 -11.83180 1.000 8.49031  ? 1470 VAL A N    1 
ATOM   157  C  CA   . VAL A 1 11  ? -13.07376 -21.81640 -10.43597 1.000 9.26402  ? 1470 VAL A CA   1 
ATOM   158  C  C    . VAL A 1 11  ? -14.25183 -21.19812 -9.68035  1.000 9.39033  ? 1470 VAL A C    1 
ATOM   159  O  O    . VAL A 1 11  ? -14.09636 -20.78917 -8.51946  1.000 8.88501  ? 1470 VAL A O    1 
ATOM   160  C  CB   . VAL A 1 11  ? -11.80152 -20.95338 -10.25902 1.000 9.64569  ? 1470 VAL A CB   1 
ATOM   161  C  CG1  . VAL A 1 11  ? -10.58044 -21.69546 -10.83919 1.000 10.27725 ? 1470 VAL A CG1  1 
ATOM   162  C  CG2  . VAL A 1 11  ? -11.98457 -19.54081 -10.87790 1.000 10.25096 ? 1470 VAL A CG2  1 
ATOM   163  H  H    . VAL A 1 11  ? -13.04785 -21.49856 -12.37307 1.000 10.18837 ? 1470 VAL A H    1 
ATOM   164  H  HA   . VAL A 1 11  ? -12.95619 -22.68753 -10.02583 1.000 11.11682 ? 1470 VAL A HA   1 
ATOM   165  H  HB   . VAL A 1 11  ? -11.63805 -20.81190 -9.31342  1.000 11.57483 ? 1470 VAL A HB   1 
ATOM   166  H  HG11 . VAL A 1 11  ? -9.78980  -21.14722 -10.71582 1.000 12.33270 ? 1470 VAL A HG11 1 
ATOM   167  H  HG12 . VAL A 1 11  ? -10.47349 -22.53971 -10.37368 1.000 12.33270 ? 1470 VAL A HG12 1 
ATOM   168  H  HG13 . VAL A 1 11  ? -10.72790 -21.85532 -11.78449 1.000 12.33270 ? 1470 VAL A HG13 1 
ATOM   169  H  HG21 . VAL A 1 11  ? -11.15063 -19.05152 -10.80025 1.000 12.30115 ? 1470 VAL A HG21 1 
ATOM   170  H  HG22 . VAL A 1 11  ? -12.22736 -19.63448 -11.81234 1.000 12.30115 ? 1470 VAL A HG22 1 
ATOM   171  H  HG23 . VAL A 1 11  ? -12.68740 -19.07472 -10.39864 1.000 12.30115 ? 1470 VAL A HG23 1 
ATOM   172  N  N    . HIS A 1 12  ? -15.44226 -21.18290 -10.30415 1.000 8.60605  ? 1471 HIS A N    1 
ATOM   173  C  CA   . HIS A 1 12  ? -16.57375 -20.58897 -9.59351  1.000 8.08496  ? 1471 HIS A CA   1 
ATOM   174  C  C    . HIS A 1 12  ? -17.89018 -21.24036 -10.03060 1.000 8.78766  ? 1471 HIS A C    1 
ATOM   175  O  O    . HIS A 1 12  ? -18.54632 -20.75747 -10.95015 1.000 9.52715  ? 1471 HIS A O    1 
ATOM   176  C  CB   . HIS A 1 12  ? -16.59391 -19.07218 -9.83486  1.000 8.10077  ? 1471 HIS A CB   1 
ATOM   177  C  CG   . HIS A 1 12  ? -17.52655 -18.34566 -8.94301  1.000 9.23502  ? 1471 HIS A CG   1 
ATOM   178  N  ND1  . HIS A 1 12  ? -17.24228 -17.08489 -8.50047  1.000 9.75355  ? 1471 HIS A ND1  1 
ATOM   179  C  CD2  . HIS A 1 12  ? -18.74951 -18.62979 -8.45370  1.000 9.39308  ? 1471 HIS A CD2  1 
ATOM   180  C  CE1  . HIS A 1 12  ? -18.22493 -16.63398 -7.75117  1.000 9.75353  ? 1471 HIS A CE1  1 
ATOM   181  N  NE2  . HIS A 1 12  ? -19.16531 -17.55940 -7.69104  1.000 9.84031  ? 1471 HIS A NE2  1 
ATOM   182  H  H    . HIS A 1 12  ? -15.60374 -21.49256 -11.09005 1.000 10.32726 ? 1471 HIS A H    1 
ATOM   183  H  HA   . HIS A 1 12  ? -16.48030 -20.79131 -8.64946  1.000 9.70195  ? 1471 HIS A HA   1 
ATOM   184  H  HB2  . HIS A 1 12  ? -15.70298 -18.71938 -9.68426  1.000 9.72092  ? 1471 HIS A HB2  1 
ATOM   185  H  HB3  . HIS A 1 12  ? -16.86675 -18.90449 -10.75046 1.000 9.72092  ? 1471 HIS A HB3  1 
ATOM   186  H  HD2  . HIS A 1 12  ? -19.22954 -19.41196 -8.60433  1.000 11.27170 ? 1471 HIS A HD2  1 
ATOM   187  H  HE1  . HIS A 1 12  ? -18.25279 -15.80328 -7.33395  1.000 11.70424 ? 1471 HIS A HE1  1 
ATOM   188  N  N    . VAL A 1 13  ? -18.31453 -22.28820 -9.30013  1.000 9.12193  ? 1472 VAL A N    1 
ATOM   189  C  CA   . VAL A 1 13  ? -19.59239 -22.92785 -9.58134  1.000 9.67719  ? 1472 VAL A CA   1 
ATOM   190  C  C    . VAL A 1 13  ? -20.35225 -23.11769 -8.29119  1.000 9.35615  ? 1472 VAL A C    1 
ATOM   191  O  O    . VAL A 1 13  ? -19.78098 -23.30901 -7.21026  1.000 10.48514 ? 1472 VAL A O    1 
ATOM   192  C  CB   . VAL A 1 13  ? -19.39528 -24.28282 -10.31165 1.000 9.82995  ? 1472 VAL A CB   1 
ATOM   193  C  CG1  . VAL A 1 13  ? -18.65193 -24.12361 -11.59769 1.000 11.41424 ? 1472 VAL A CG1  1 
ATOM   194  C  CG2  . VAL A 1 13  ? -18.87102 -25.35481 -9.37727  1.000 11.12210 ? 1472 VAL A CG2  1 
ATOM   195  H  H    . VAL A 1 13  ? -17.87720 -22.63510 -8.64591  1.000 10.94632 ? 1472 VAL A H    1 
ATOM   196  H  HA   . VAL A 1 13  ? -20.12325 -22.34563 -10.14712 1.000 11.61262 ? 1472 VAL A HA   1 
ATOM   197  H  HB   . VAL A 1 13  ? -20.26142 -24.61978 -10.58942 1.000 11.79594 ? 1472 VAL A HB   1 
ATOM   198  H  HG11 . VAL A 1 13  ? -18.58231 -24.98846 -12.03137 1.000 13.69708 ? 1472 VAL A HG11 1 
ATOM   199  H  HG12 . VAL A 1 13  ? -19.13583 -23.50572 -12.16774 1.000 13.69708 ? 1472 VAL A HG12 1 
ATOM   200  H  HG13 . VAL A 1 13  ? -17.76625 -23.77567 -11.40953 1.000 13.69708 ? 1472 VAL A HG13 1 
ATOM   201  H  HG21 . VAL A 1 13  ? -18.67475 -26.15353 -9.89150  1.000 13.34653 ? 1472 VAL A HG21 1 
ATOM   202  H  HG22 . VAL A 1 13  ? -18.06387 -25.03167 -8.94716  1.000 13.34653 ? 1472 VAL A HG22 1 
ATOM   203  H  HG23 . VAL A 1 13  ? -19.54672 -25.54934 -8.70908  1.000 13.34653 ? 1472 VAL A HG23 1 
ATOM   204  N  N    . HIS A 1 14  ? -21.68185 -23.18058 -8.42824  1.000 9.37201  ? 1473 HIS A N    1 
ATOM   205  C  CA   . HIS A 1 14  ? -22.58627 -23.51920 -7.33021  1.000 9.07716  ? 1473 HIS A CA   1 
ATOM   206  C  C    . HIS A 1 14  ? -23.26715 -24.83269 -7.68812  1.000 9.54831  ? 1473 HIS A C    1 
ATOM   207  O  O    . HIS A 1 14  ? -24.05140 -24.86842 -8.62436  1.000 10.76413 ? 1473 HIS A O    1 
ATOM   208  C  CB   . HIS A 1 14  ? -23.62095 -22.41817 -7.13175  1.000 9.66931  ? 1473 HIS A CB   1 
ATOM   209  C  CG   . HIS A 1 14  ? -23.01769 -21.11468 -6.69786  1.000 8.56131  ? 1473 HIS A CG   1 
ATOM   210  N  ND1  . HIS A 1 14  ? -22.85155 -20.77566 -5.38336  1.000 8.95347  ? 1473 HIS A ND1  1 
ATOM   211  C  CD2  . HIS A 1 14  ? -22.52566 -20.08657 -7.43920  1.000 10.10091 ? 1473 HIS A CD2  1 
ATOM   212  C  CE1  . HIS A 1 14  ? -22.28008 -19.57148 -5.31351  1.000 9.20341  ? 1473 HIS A CE1  1 
ATOM   213  N  NE2  . HIS A 1 14  ? -22.05001 -19.15282 -6.54380  1.000 9.09834  ? 1473 HIS A NE2  1 
ATOM   214  H  H    . HIS A 1 14  ? -22.09098 -23.02648 -9.16882  1.000 11.24641 ? 1473 HIS A H    1 
ATOM   215  H  HA   . HIS A 1 14  ? -22.08580 -23.63133 -6.50689  1.000 10.89260 ? 1473 HIS A HA   1 
ATOM   216  H  HB2  . HIS A 1 14  ? -24.08525 -22.26821 -7.97011  1.000 11.60317 ? 1473 HIS A HB2  1 
ATOM   217  H  HB3  . HIS A 1 14  ? -24.25077 -22.69790 -6.44912  1.000 11.60317 ? 1473 HIS A HB3  1 
ATOM   218  H  HD1  . HIS A 1 14  ? -23.07871 -21.26030 -4.71021  1.000 10.74416 ? 1473 HIS A HD1  1 
ATOM   219  H  HD2  . HIS A 1 14  ? -22.51262 -20.02543 -8.36710  1.000 12.12110 ? 1473 HIS A HD2  1 
ATOM   220  H  HE1  . HIS A 1 14  ? -22.07882 -19.10770 -4.53293  1.000 11.04409 ? 1473 HIS A HE1  1 
ATOM   221  N  N    . LEU A 1 15  ? -22.97956 -25.87743 -6.93158  1.000 9.82728  ? 1474 LEU A N    1 
ATOM   222  C  CA   . LEU A 1 15  ? -23.53545 -27.20464 -7.20486  1.000 10.67475 ? 1474 LEU A CA   1 
ATOM   223  C  C    . LEU A 1 15  ? -24.67546 -27.59593 -6.29295  1.000 10.50105 ? 1474 LEU A C    1 
ATOM   224  O  O    . LEU A 1 15  ? -25.27003 -28.67275 -6.50691  1.000 12.13539 ? 1474 LEU A O    1 
ATOM   225  C  CB   . LEU A 1 15  ? -22.42141 -28.26990 -7.22105  1.000 11.76434 ? 1474 LEU A CB   1 
ATOM   226  C  CG   . LEU A 1 15  ? -21.33691 -27.98200 -8.24509  1.000 12.39351 ? 1474 LEU A CG   1 
ATOM   227  C  CD1  . LEU A 1 15  ? -20.22247 -29.06154 -8.18521  1.000 15.30414 ? 1474 LEU A CD1  1 
ATOM   228  C  CD2  . LEU A 1 15  ? -21.86592 -27.85612 -9.61458  1.000 15.31195 ? 1474 LEU A CD2  1 
ATOM   229  H  H    . LEU A 1 15  ? -22.46070 -25.84942 -6.24631  1.000 11.79274 ? 1474 LEU A H    1 
ATOM   230  H  HA   . LEU A 1 15  ? -23.91209 -27.19528 -8.09871  1.000 12.80971 ? 1474 LEU A HA   1 
ATOM   231  H  HB2  . LEU A 1 15  ? -22.00559 -28.30239 -6.34531  1.000 14.11721 ? 1474 LEU A HB2  1 
ATOM   232  H  HB3  . LEU A 1 15  ? -22.81377 -29.13102 -7.43417  1.000 14.11721 ? 1474 LEU A HB3  1 
ATOM   233  H  HG   . LEU A 1 15  ? -20.94805 -27.12235 -8.01993  1.000 14.87222 ? 1474 LEU A HG   1 
ATOM   234  H  HD11 . LEU A 1 15  ? -19.53707 -28.84432 -8.83632  1.000 18.36497 ? 1474 LEU A HD11 1 
ATOM   235  H  HD12 . LEU A 1 15  ? -19.84040 -29.07189 -7.29369  1.000 18.36497 ? 1474 LEU A HD12 1 
ATOM   236  H  HD13 . LEU A 1 15  ? -20.60996 -29.92709 -8.38910  1.000 18.36497 ? 1474 LEU A HD13 1 
ATOM   237  H  HD21 . LEU A 1 15  ? -21.12949 -27.90894 -10.24369 1.000 18.37434 ? 1474 LEU A HD21 1 
ATOM   238  H  HD22 . LEU A 1 15  ? -22.49326 -28.57759 -9.77835  1.000 18.37434 ? 1474 LEU A HD22 1 
ATOM   239  H  HD23 . LEU A 1 15  ? -22.31514 -27.00089 -9.70223  1.000 18.37434 ? 1474 LEU A HD23 1 
ATOM   240  N  N    . ARG A 1 16  ? -25.00665 -26.76374 -5.30935  1.000 10.38785 ? 1475 ARG A N    1 
ATOM   241  C  CA   . ARG A 1 16  ? -26.27327 -26.79688 -4.56310  1.000 10.57747 ? 1475 ARG A CA   1 
ATOM   242  C  C    . ARG A 1 16  ? -26.43488 -27.96740 -3.61547  1.000 12.50668 ? 1475 ARG A C    1 
ATOM   243  O  O    . ARG A 1 16  ? -27.42850 -28.02857 -2.95572  1.000 18.67275 ? 1475 ARG A O    1 
ATOM   244  C  CB   . ARG A 1 16  ? -27.49479 -26.66937 -5.45579  1.000 11.23528 ? 1475 ARG A CB   1 
ATOM   245  C  CG   . ARG A 1 16  ? -27.42328 -25.47322 -6.38890  1.000 10.51418 ? 1475 ARG A CG   1 
ATOM   246  C  CD   . ARG A 1 16  ? -27.42457 -24.15529 -5.62848  1.000 10.42730 ? 1475 ARG A CD   1 
ATOM   247  N  NE   . ARG A 1 16  ? -27.71311 -23.05752 -6.51879  1.000 10.20890 ? 1475 ARG A NE   1 
ATOM   248  C  CZ   . ARG A 1 16  ? -27.27015 -21.81200 -6.36559  1.000 10.04833 ? 1475 ARG A CZ   1 
ATOM   249  N  NH1  . ARG A 1 16  ? -26.52831 -21.45857 -5.34205  1.000 10.86424 ? 1475 ARG A NH1  1 
ATOM   250  N  NH2  . ARG A 1 16  ? -27.58534 -20.90631 -7.28260  1.000 10.96156 ? 1475 ARG A NH2  1 
ATOM   251  H  H    . ARG A 1 16  ? -24.48574 -26.13494 -5.03941  1.000 12.46542 ? 1475 ARG A H    1 
ATOM   252  H  HA   . ARG A 1 16  ? -26.25881 -26.01647 -3.98720  1.000 12.69296 ? 1475 ARG A HA   1 
ATOM   253  H  HB2  . ARG A 1 16  ? -27.57272 -27.46910 -5.99917  1.000 13.48233 ? 1475 ARG A HB2  1 
ATOM   254  H  HB3  . ARG A 1 16  ? -28.28268 -26.56847 -4.89905  1.000 13.48233 ? 1475 ARG A HB3  1 
ATOM   255  H  HG2  . ARG A 1 16  ? -26.60561 -25.52202 -6.90845  1.000 12.61702 ? 1475 ARG A HG2  1 
ATOM   256  H  HG3  . ARG A 1 16  ? -28.19269 -25.48257 -6.97951  1.000 12.61702 ? 1475 ARG A HG3  1 
ATOM   257  H  HD2  . ARG A 1 16  ? -28.10479 -24.17977 -4.93740  1.000 12.51277 ? 1475 ARG A HD2  1 
ATOM   258  H  HD3  . ARG A 1 16  ? -26.55220 -24.00925 -5.23031  1.000 12.51277 ? 1475 ARG A HD3  1 
ATOM   259  H  HE   . ARG A 1 16  ? -28.20994 -23.22063 -7.20155  1.000 12.25068 ? 1475 ARG A HE   1 
ATOM   260  H  HH11 . ARG A 1 16  ? -26.31460 -22.03943 -4.74495  1.000 13.03708 ? 1475 ARG A HH11 1 
ATOM   261  H  HH12 . ARG A 1 16  ? -26.25598 -20.64615 -5.26852  1.000 13.03708 ? 1475 ARG A HH12 1 
ATOM   262  H  HH21 . ARG A 1 16  ? -28.06696 -21.12916 -7.95934  1.000 13.15387 ? 1475 ARG A HH21 1 
ATOM   263  H  HH22 . ARG A 1 16  ? -27.30800 -20.09643 -7.20023  1.000 13.15387 ? 1475 ARG A HH22 1 
ATOM   264  N  N    . GLU A 1 17  ? -25.53193 -28.90461 -3.58244  1.000 12.96708 ? 1476 GLU A N    1 
ATOM   265  C  CA   . GLU A 1 17  ? -25.55796 -30.03716 -2.68560  1.000 12.65136 ? 1476 GLU A CA   1 
ATOM   266  C  C    . GLU A 1 17  ? -24.48329 -29.82101 -1.63624  1.000 13.67517 ? 1476 GLU A C    1 
ATOM   267  O  O    . GLU A 1 17  ? -23.33789 -29.56526 -2.00025  1.000 15.73052 ? 1476 GLU A O    1 
ATOM   268  C  CB   . GLU A 1 17  ? -25.32453 -31.31550 -3.48518  1.000 12.78020 ? 1476 GLU A CB   1 
ATOM   269  C  CG   . GLU A 1 17  ? -25.42886 -32.59692 -2.64114  1.000 13.61980 ? 1476 GLU A CG   1 
ATOM   270  C  CD   . GLU A 1 17  ? -25.32612 -33.88341 -3.43458  1.000 12.85667 ? 1476 GLU A CD   1 
ATOM   271  O  OE1  . GLU A 1 17  ? -25.09074 -33.84512 -4.64379  1.000 14.10669 ? 1476 GLU A OE1  1 
ATOM   272  O  OE2  . GLU A 1 17  ? -25.50069 -34.95650 -2.85036  1.000 15.24887 ? 1476 GLU A OE2  1 
ATOM   273  H  H    . GLU A 1 17  ? -24.84591 -28.91452 -4.10097  1.000 15.56050 ? 1476 GLU A H    1 
ATOM   274  H  HA   . GLU A 1 17  ? -26.41218 -30.12217 -2.23395  1.000 15.18163 ? 1476 GLU A HA   1 
ATOM   275  H  HB2  . GLU A 1 17  ? -25.98912 -31.36913 -4.18970  1.000 15.33623 ? 1476 GLU A HB2  1 
ATOM   276  H  HB3  . GLU A 1 17  ? -24.43470 -31.28518 -3.87011  1.000 15.33623 ? 1476 GLU A HB3  1 
ATOM   277  H  HG2  . GLU A 1 17  ? -24.71035 -32.59726 -1.98949  1.000 16.34376 ? 1476 GLU A HG2  1 
ATOM   278  H  HG3  . GLU A 1 17  ? -26.28695 -32.60021 -2.18885  1.000 16.34376 ? 1476 GLU A HG3  1 
ATOM   279  N  N    . PRO A 1 18  ? -24.78773 -29.83316 -0.36485  1.000 13.81470 ? 1477 PRO A N    1 
ATOM   280  C  CA   . PRO A 1 18  ? -26.07946 -30.20607 0.23865   1.000 15.09106 ? 1477 PRO A CA   1 
ATOM   281  C  C    . PRO A 1 18  ? -27.15330 -29.11937 0.22725   1.000 14.82259 ? 1477 PRO A C    1 
ATOM   282  O  O    . PRO A 1 18  ? -26.85857 -27.91917 0.25242   1.000 13.98831 ? 1477 PRO A O    1 
ATOM   283  C  CB   . PRO A 1 18  ? -25.68117 -30.50386 1.69026   1.000 16.92543 ? 1477 PRO A CB   1 
ATOM   284  C  CG   . PRO A 1 18  ? -24.49094 -29.58232 1.93883   1.000 18.35449 ? 1477 PRO A CG   1 
ATOM   285  C  CD   . PRO A 1 18  ? -23.75817 -29.60444 0.66544   1.000 16.47012 ? 1477 PRO A CD   1 
ATOM   286  H  HA   . PRO A 1 18  ? -26.41134 -30.98484 -0.23492  1.000 18.10927 ? 1477 PRO A HA   1 
ATOM   287  H  HB2  . PRO A 1 18  ? -26.41652 -30.29723 2.28814   1.000 20.31052 ? 1477 PRO A HB2  1 
ATOM   288  H  HB3  . PRO A 1 18  ? -25.42949 -31.43597 1.78370   1.000 20.31052 ? 1477 PRO A HB3  1 
ATOM   289  H  HG2  . PRO A 1 18  ? -24.79863 -28.68732 2.15145   1.000 22.02539 ? 1477 PRO A HG2  1 
ATOM   290  H  HG3  . PRO A 1 18  ? -23.94599 -29.92671 2.66363   1.000 22.02539 ? 1477 PRO A HG3  1 
ATOM   291  H  HD2  . PRO A 1 18  ? -23.31281 -28.75570 0.51639   1.000 19.76414 ? 1477 PRO A HD2  1 
ATOM   292  H  HD3  . PRO A 1 18  ? -23.10889 -30.32507 0.66100   1.000 19.76414 ? 1477 PRO A HD3  1 
ATOM   293  N  N    . GLY A 1 19  ? -28.41759 -29.54182 0.22083   1.000 15.83061 ? 1478 GLY A N    1 
ATOM   294  C  CA   . GLY A 1 19  ? -29.51221 -28.72338 0.70822   1.000 16.55435 ? 1478 GLY A CA   1 
ATOM   295  C  C    . GLY A 1 19  ? -30.32546 -27.99035 -0.33485  1.000 17.13077 ? 1478 GLY A C    1 
ATOM   296  O  O    . GLY A 1 19  ? -31.40027 -27.44171 -0.00066  1.000 19.14930 ? 1478 GLY A O    1 
ATOM   297  H  H    . GLY A 1 19  ? -28.66477 -30.31351 -0.06726  1.000 18.99673 ? 1478 GLY A H    1 
ATOM   298  H  HA2  . GLY A 1 19  ? -30.12249 -29.29424 1.20075   1.000 19.86522 ? 1478 GLY A HA2  1 
ATOM   299  H  HA3  . GLY A 1 19  ? -29.14788 -28.05631 1.31086   1.000 19.86522 ? 1478 GLY A HA3  1 
ATOM   300  N  N    . GLY A 1 20  ? -29.89836 -27.96912 -1.56327  1.000 16.20431 ? 1479 GLY A N    1 
ATOM   301  C  CA   . GLY A 1 20  ? -30.61966 -27.31003 -2.62724  1.000 15.21733 ? 1479 GLY A CA   1 
ATOM   302  C  C    . GLY A 1 20  ? -30.71717 -28.18931 -3.85606  1.000 13.26987 ? 1479 GLY A C    1 
ATOM   303  O  O    . GLY A 1 20  ? -30.65391 -27.69599 -4.99564  1.000 13.70140 ? 1479 GLY A O    1 
ATOM   304  H  H    . GLY A 1 20  ? -29.16784 -28.34020 -1.82449  1.000 19.44517 ? 1479 GLY A H    1 
ATOM   305  H  HA2  . GLY A 1 20  ? -31.51690 -27.09596 -2.32718  1.000 18.26080 ? 1479 GLY A HA2  1 
ATOM   306  H  HA3  . GLY A 1 20  ? -30.16318 -26.48898 -2.86891  1.000 18.26080 ? 1479 GLY A HA3  1 
ATOM   307  N  N    . THR A 1 21  ? -30.89260 -29.51939 -3.67198  1.000 14.07771 ? 1480 THR A N    1 
ATOM   308  C  CA   . THR A 1 21  ? -30.64447 -30.46238 -4.75266  1.000 12.78822 ? 1480 THR A CA   1 
ATOM   309  C  C    . THR A 1 21  ? -31.72669 -30.48687 -5.82934  1.000 12.68295 ? 1480 THR A C    1 
ATOM   310  O  O    . THR A 1 21  ? -31.50942 -31.09761 -6.86287  1.000 14.69884 ? 1480 THR A O    1 
ATOM   311  C  CB   . THR A 1 21  ? -30.38004 -31.87010 -4.21880  1.000 14.59893 ? 1480 THR A CB   1 
ATOM   312  O  OG1  . THR A 1 21  ? -31.51646 -32.34411 -3.48795  1.000 16.92538 ? 1480 THR A OG1  1 
ATOM   313  C  CG2  . THR A 1 21  ? -29.12461 -31.93819 -3.30554  1.000 15.13574 ? 1480 THR A CG2  1 
ATOM   314  H  H    . THR A 1 21  ? -31.15127 -29.88159 -2.93612  1.000 16.89325 ? 1480 THR A H    1 
ATOM   315  H  HA   . THR A 1 21  ? -29.82882 -30.17487 -5.19192  1.000 15.34586 ? 1480 THR A HA   1 
ATOM   316  H  HB   . THR A 1 21  ? -30.21323 -32.44508 -4.98200  1.000 17.51871 ? 1480 THR A HB   1 
ATOM   317  H  HG1  . THR A 1 21  ? -31.67913 -31.82951 -2.84427  1.000 20.31046 ? 1480 THR A HG1  1 
ATOM   318  H  HG21 . THR A 1 21  ? -28.99061 -32.84662 -2.99297  1.000 18.16289 ? 1480 THR A HG21 1 
ATOM   319  H  HG22 . THR A 1 21  ? -28.33908 -31.65628 -3.79988  1.000 18.16289 ? 1480 THR A HG22 1 
ATOM   320  H  HG23 . THR A 1 21  ? -29.24006 -31.35528 -2.53887  1.000 18.16289 ? 1480 THR A HG23 1 
ATOM   321  N  N    . HIS A 1 22  ? -32.86893 -29.80393 -5.62302  1.000 13.82252 ? 1481 HIS A N    1 
ATOM   322  C  CA   . HIS A 1 22  ? -33.82218 -29.58157 -6.70356  1.000 14.75669 ? 1481 HIS A CA   1 
ATOM   323  C  C    . HIS A 1 22  ? -33.28099 -28.59098 -7.73396  1.000 13.57249 ? 1481 HIS A C    1 
ATOM   324  O  O    . HIS A 1 22  ? -33.72806 -28.56743 -8.88481  1.000 14.97253 ? 1481 HIS A O    1 
ATOM   325  C  CB   . HIS A 1 22  ? -35.16965 -29.09927 -6.16823  1.000 14.19092 ? 1481 HIS A CB   1 
ATOM   326  C  CG   . HIS A 1 22  ? -35.09701 -27.76897 -5.49360  1.000 14.75942 ? 1481 HIS A CG   1 
ATOM   327  N  ND1  . HIS A 1 22  ? -34.47893 -27.59123 -4.26772  1.000 15.53320 ? 1481 HIS A ND1  1 
ATOM   328  C  CD2  . HIS A 1 22  ? -35.49679 -26.54165 -5.90234  1.000 15.31473 ? 1481 HIS A CD2  1 
ATOM   329  C  CE1  . HIS A 1 22  ? -34.54060 -26.30997 -3.93738  1.000 15.95430 ? 1481 HIS A CE1  1 
ATOM   330  N  NE2  . HIS A 1 22  ? -35.14810 -25.65230 -4.91959  1.000 15.68057 ? 1481 HIS A NE2  1 
ATOM   331  H  H    . HIS A 1 22  ? -33.10572 -29.46499 -4.86894  1.000 16.58702 ? 1481 HIS A H    1 
ATOM   332  H  HA   . HIS A 1 22  ? -33.98767 -30.42977 -7.14410  1.000 17.70803 ? 1481 HIS A HA   1 
ATOM   333  H  HB2  . HIS A 1 22  ? -35.79219 -29.02420 -6.90830  1.000 17.02911 ? 1481 HIS A HB2  1 
ATOM   334  H  HB3  . HIS A 1 22  ? -35.49878 -29.74331 -5.52187  1.000 17.02911 ? 1481 HIS A HB3  1 
ATOM   335  H  HD2  . HIS A 1 22  ? -35.92781 -26.33971 -6.70130  1.000 18.37767 ? 1481 HIS A HD2  1 
ATOM   336  H  HE1  . HIS A 1 22  ? -34.21425 -25.93443 -3.15166  1.000 19.14515 ? 1481 HIS A HE1  1 
ATOM   337  H  HE2  . HIS A 1 22  ? -35.29812 -24.80564 -4.93585  1.000 18.81668 ? 1481 HIS A HE2  1 
ATOM   338  N  N    . LYS A 1 23  ? -32.30227 -27.76380 -7.36897  1.000 11.68283 ? 1482 LYS A N    1 
ATOM   339  C  CA   . LYS A 1 23  ? -31.72447 -26.80499 -8.29326  1.000 11.95381 ? 1482 LYS A CA   1 
ATOM   340  C  C    . LYS A 1 23  ? -30.59167 -27.41545 -9.12480  1.000 11.12213 ? 1482 LYS A C    1 
ATOM   341  O  O    . LYS A 1 23  ? -30.35512 -26.98465 -10.25498 1.000 11.27480 ? 1482 LYS A O    1 
ATOM   342  C  CB   . LYS A 1 23  ? -31.12014 -25.62601 -7.50843  1.000 12.53810 ? 1482 LYS A CB   1 
ATOM   343  C  CG   . LYS A 1 23  ? -32.06179 -24.87527 -6.56282  1.000 12.25121 ? 1482 LYS A CG   1 
ATOM   344  C  CD   . LYS A 1 23  ? -31.26602 -23.88029 -5.70574  1.000 12.65389 ? 1482 LYS A CD   1 
ATOM   345  C  CE   . LYS A 1 23  ? -32.11984 -23.08444 -4.74708  1.000 12.91180 ? 1482 LYS A CE   1 
ATOM   346  N  NZ   . LYS A 1 23  ? -32.94537 -22.08745 -5.42881  1.000 11.79331 ? 1482 LYS A NZ   1 
ATOM   347  H  H    . LYS A 1 23  ? -31.95525 -27.74178 -6.58240  1.000 14.01940 ? 1482 LYS A H    1 
ATOM   348  H  HA   . LYS A 1 23  ? -32.42544 -26.48190 -8.88076  1.000 14.34457 ? 1482 LYS A HA   1 
ATOM   349  H  HB2  . LYS A 1 23  ? -30.38944 -25.96705 -6.96929  1.000 15.04572 ? 1482 LYS A HB2  1 
ATOM   350  H  HB3  . LYS A 1 23  ? -30.78590 -24.97863 -8.14881  1.000 15.04572 ? 1482 LYS A HB3  1 
ATOM   351  H  HG2  . LYS A 1 23  ? -32.71962 -24.38384 -7.07920  1.000 14.70145 ? 1482 LYS A HG2  1 
ATOM   352  H  HG3  . LYS A 1 23  ? -32.50557 -25.50634 -5.97486  1.000 14.70145 ? 1482 LYS A HG3  1 
ATOM   353  H  HD2  . LYS A 1 23  ? -30.61314 -24.37083 -5.18227  1.000 15.18466 ? 1482 LYS A HD2  1 
ATOM   354  H  HD3  . LYS A 1 23  ? -30.81654 -23.25195 -6.29230  1.000 15.18466 ? 1482 LYS A HD3  1 
ATOM   355  H  HE2  . LYS A 1 23  ? -32.71014 -23.68909 -4.27080  1.000 15.49416 ? 1482 LYS A HE2  1 
ATOM   356  H  HE3  . LYS A 1 23  ? -31.54401 -22.62013 -4.11961  1.000 15.49416 ? 1482 LYS A HE3  1 
ATOM   357  H  HZ1  . LYS A 1 23  ? -33.78510 -22.13736 -5.13816  1.000 14.15197 ? 1482 LYS A HZ1  1 
ATOM   358  H  HZ2  . LYS A 1 23  ? -32.63177 -21.27042 -5.26691  1.000 14.15197 ? 1482 LYS A HZ2  1 
ATOM   359  H  HZ3  . LYS A 1 23  ? -32.93456 -22.23225 -6.30688  1.000 14.15197 ? 1482 LYS A HZ3  1 
ATOM   360  N  N    . GLU A 1 24  ? -29.87810 -28.36635 -8.53180  1.000 11.91956 ? 1483 GLU A N    1 
ATOM   361  C  CA   . GLU A 1 24  ? -28.66937 -28.99173 -9.07123  1.000 11.04847 ? 1483 GLU A CA   1 
ATOM   362  C  C    . GLU A 1 24  ? -28.17433 -29.91730 -7.98554  1.000 10.04574 ? 1483 GLU A C    1 
ATOM   363  O  O    . GLU A 1 24  ? -28.39676 -29.67981 -6.79808  1.000 10.59836 ? 1483 GLU A O    1 
ATOM   364  C  CB   . GLU A 1 24  ? -27.58305 -27.90084 -9.30969  1.000 11.08005 ? 1483 GLU A CB   1 
ATOM   365  C  CG   . GLU A 1 24  ? -26.53569 -28.31413 -10.35920 1.000 11.03792 ? 1483 GLU A CG   1 
ATOM   366  C  CD   . GLU A 1 24  ? -27.07365 -28.24350 -11.76249 1.000 10.86691 ? 1483 GLU A CD   1 
ATOM   367  O  OE1  . GLU A 1 24  ? -27.79255 -29.21533 -12.17254 1.000 11.27738 ? 1483 GLU A OE1  1 
ATOM   368  O  OE2  . GLU A 1 24  ? -26.89034 -27.20460 -12.40966 1.000 11.34845 ? 1483 GLU A OE2  1 
ATOM   369  H  H    . GLU A 1 24  ? -30.08456 -28.69148 -7.76286  1.000 14.30347 ? 1483 GLU A H    1 
ATOM   370  H  HA   . GLU A 1 24  ? -28.83611 -29.45243 -9.90840  1.000 13.25816 ? 1483 GLU A HA   1 
ATOM   371  H  HB2  . GLU A 1 24  ? -28.01458 -27.08971 -9.62073  1.000 13.29606 ? 1483 GLU A HB2  1 
ATOM   372  H  HB3  . GLU A 1 24  ? -27.11932 -27.73074 -8.47487  1.000 13.29606 ? 1483 GLU A HB3  1 
ATOM   373  H  HG2  . GLU A 1 24  ? -25.77263 -27.71837 -10.29826 1.000 13.24550 ? 1483 GLU A HG2  1 
ATOM   374  H  HG3  . GLU A 1 24  ? -26.25788 -29.22762 -10.18819 1.000 13.24550 ? 1483 GLU A HG3  1 
ATOM   375  N  N    . ASP A 1 25  ? -27.40929 -30.94849 -8.37326  1.000 11.49059 ? 1484 ASP A N    1 
ATOM   376  C  CA   . ASP A 1 25  ? -26.62585 -31.66795 -7.36873  1.000 11.08799 ? 1484 ASP A CA   1 
ATOM   377  C  C    . ASP A 1 25  ? -25.24240 -31.92916 -7.97014  1.000 10.66160 ? 1484 ASP A C    1 
ATOM   378  O  O    . ASP A 1 25  ? -24.94166 -31.52283 -9.09176  1.000 11.50110 ? 1484 ASP A O    1 
ATOM   379  C  CB   . ASP A 1 25  ? -27.32941 -32.92770 -6.81558  1.000 13.03022 ? 1484 ASP A CB   1 
ATOM   380  C  CG   . ASP A 1 25  ? -27.72793 -33.91372 -7.86536  1.000 14.10937 ? 1484 ASP A CG   1 
ATOM   381  O  OD1  . ASP A 1 25  ? -28.67902 -34.69633 -7.56785  1.000 17.27538 ? 1484 ASP A OD1  1 
ATOM   382  O  OD2  . ASP A 1 25  ? -27.19035 -33.93162 -8.95626  1.000 12.79610 ? 1484 ASP A OD2  1 
ATOM   383  H  H    . ASP A 1 25  ? -27.33367 -31.23507 -9.18057  1.000 13.78871 ? 1484 ASP A H    1 
ATOM   384  H  HA   . ASP A 1 25  ? -26.51188 -31.10551 -6.58671  1.000 13.30559 ? 1484 ASP A HA   1 
ATOM   385  H  HB2  . ASP A 1 25  ? -26.72618 -33.37729 -6.20331  1.000 15.63626 ? 1484 ASP A HB2  1 
ATOM   386  H  HB3  . ASP A 1 25  ? -28.13403 -32.65446 -6.34780  1.000 15.63626 ? 1484 ASP A HB3  1 
ATOM   387  N  N    . PHE A 1 26  ? -24.36003 -32.59262 -7.20691  1.000 11.18269 ? 1485 PHE A N    1 
ATOM   388  C  CA   . PHE A 1 26  ? -23.02030 -32.82610 -7.73770  1.000 11.40378 ? 1485 PHE A CA   1 
ATOM   389  C  C    . PHE A 1 26  ? -23.11529 -33.58364 -9.06283  1.000 10.82214 ? 1485 PHE A C    1 
ATOM   390  O  O    . PHE A 1 26  ? -22.39159 -33.29143 -10.01373 1.000 11.03791 ? 1485 PHE A O    1 
ATOM   391  C  CB   . PHE A 1 26  ? -22.12988 -33.56891 -6.74903  1.000 12.73023 ? 1485 PHE A CB   1 
ATOM   392  C  CG   . PHE A 1 26  ? -21.55915 -32.70321 -5.67524  1.000 14.04888 ? 1485 PHE A CG   1 
ATOM   393  C  CD1  . PHE A 1 26  ? -20.56980 -31.78733 -5.95995  1.000 16.99380 ? 1485 PHE A CD1  1 
ATOM   394  C  CD2  . PHE A 1 26  ? -21.99652 -32.80849 -4.36843  1.000 13.96989 ? 1485 PHE A CD2  1 
ATOM   395  C  CE1  . PHE A 1 26  ? -20.03497 -30.97348 -4.93240  1.000 18.10978 ? 1485 PHE A CE1  1 
ATOM   396  C  CE2  . PHE A 1 26  ? -21.46785 -32.02903 -3.37609  1.000 15.66474 ? 1485 PHE A CE2  1 
ATOM   397  C  CZ   . PHE A 1 26  ? -20.51452 -31.09772 -3.67152  1.000 17.69135 ? 1485 PHE A CZ   1 
ATOM   398  H  H    . PHE A 1 26  ? -24.50961 -32.90073 -6.41805  1.000 13.41923 ? 1485 PHE A H    1 
ATOM   399  H  HA   . PHE A 1 26  ? -22.59276 -31.96757 -7.88275  1.000 13.68454 ? 1485 PHE A HA   1 
ATOM   400  H  HB2  . PHE A 1 26  ? -22.65368 -34.26371 -6.32033  1.000 15.27628 ? 1485 PHE A HB2  1 
ATOM   401  H  HB3  . PHE A 1 26  ? -21.38872 -33.96394 -7.23435  1.000 15.27628 ? 1485 PHE A HB3  1 
ATOM   402  H  HD1  . PHE A 1 26  ? -20.25233 -31.70352 -6.83005  1.000 20.39256 ? 1485 PHE A HD1  1 
ATOM   403  H  HD2  . PHE A 1 26  ? -22.66376 -33.42167 -4.15938  1.000 16.76387 ? 1485 PHE A HD2  1 
ATOM   404  H  HE1  . PHE A 1 26  ? -19.36173 -30.36022 -5.12094  1.000 21.73174 ? 1485 PHE A HE1  1 
ATOM   405  H  HE2  . PHE A 1 26  ? -21.75843 -32.13382 -2.49889  1.000 18.79769 ? 1485 PHE A HE2  1 
ATOM   406  H  HZ   . PHE A 1 26  ? -20.19059 -30.54227 -2.99962  1.000 21.22962 ? 1485 PHE A HZ   1 
ATOM   407  N  N    . ALA A 1 27  ? -23.99458 -34.59713 -9.13270  1.000 11.84596 ? 1486 ALA A N    1 
ATOM   408  C  CA   . ALA A 1 27  ? -24.10754 -35.42061 -10.32202 1.000 13.03547 ? 1486 ALA A CA   1 
ATOM   409  C  C    . ALA A 1 27  ? -24.57288 -34.61316 -11.53300 1.000 11.98550 ? 1486 ALA A C    1 
ATOM   410  O  O    . ALA A 1 27  ? -24.02189 -34.73872 -12.63879 1.000 13.10915 ? 1486 ALA A O    1 
ATOM   411  C  CB   . ALA A 1 27  ? -25.01315 -36.62723 -10.05628 1.000 13.91718 ? 1486 ALA A CB   1 
ATOM   412  H  H    . ALA A 1 27  ? -24.53250 -34.82036 -8.49992  1.000 14.21515 ? 1486 ALA A H    1 
ATOM   413  H  HA   . ALA A 1 27  ? -23.22744 -35.76663 -10.53789 1.000 15.64256 ? 1486 ALA A HA   1 
ATOM   414  H  HB1  . ALA A 1 27  ? -25.07838 -37.15750 -10.86588 1.000 16.70062 ? 1486 ALA A HB1  1 
ATOM   415  H  HB2  . ALA A 1 27  ? -24.62865 -37.15950 -9.34232  1.000 16.70062 ? 1486 ALA A HB2  1 
ATOM   416  H  HB3  . ALA A 1 27  ? -25.89250 -36.31091 -9.79630  1.000 16.70062 ? 1486 ALA A HB3  1 
ATOM   417  N  N    . SER A 1 28  ? -25.60971 -33.79386 -11.36757 1.000 12.09863 ? 1487 SER A N    1 
ATOM   418  C  CA   . SER A 1 28  ? -26.12649 -33.04748 -12.51050 1.000 12.63018 ? 1487 SER A CA   1 
ATOM   419  C  C    . SER A 1 28  ? -25.20727 -31.89059 -12.87288 1.000 11.81958 ? 1487 SER A C    1 
ATOM   420  O  O    . SER A 1 28  ? -25.06141 -31.56965 -14.04211 1.000 11.81432 ? 1487 SER A O    1 
ATOM   421  C  CB   . SER A 1 28  ? -27.56843 -32.56992 -12.25085 1.000 13.09602 ? 1487 SER A CB   1 
ATOM   422  O  OG   . SER A 1 28  ? -27.65541 -31.64474 -11.17695 1.000 12.10123 ? 1487 SER A OG   1 
ATOM   423  H  H    . SER A 1 28  ? -26.02035 -33.65623 -10.62458 1.000 14.51836 ? 1487 SER A H    1 
ATOM   424  H  HA   . SER A 1 28  ? -26.17055 -33.63960 -13.27755 1.000 15.15622 ? 1487 SER A HA   1 
ATOM   425  H  HB2  . SER A 1 28  ? -27.90037 -32.14075 -13.05493 1.000 15.71522 ? 1487 SER A HB2  1 
ATOM   426  H  HB3  . SER A 1 28  ? -28.11504 -33.34225 -12.03721 1.000 15.71522 ? 1487 SER A HB3  1 
ATOM   427  H  HG   . SER A 1 28  ? -27.20997 -30.95519 -11.35501 1.000 14.52148 ? 1487 SER A HG   1 
ATOM   428  N  N    . GLY A 1 29  ? -24.68911 -31.19156 -11.86134 1.000 11.89851 ? 1488 GLY A N    1 
ATOM   429  C  CA   . GLY A 1 29  ? -23.85430 -30.02445 -12.13594 1.000 10.65629 ? 1488 GLY A CA   1 
ATOM   430  C  C    . GLY A 1 29  ? -22.54956 -30.41190 -12.79098 1.000 10.00626 ? 1488 GLY A C    1 
ATOM   431  O  O    . GLY A 1 29  ? -22.04107 -29.68830 -13.64504 1.000 11.16425 ? 1488 GLY A O    1 
ATOM   432  H  H    . GLY A 1 29  ? -24.80291 -31.36776 -11.02731 1.000 14.27821 ? 1488 GLY A H    1 
ATOM   433  H  HA2  . GLY A 1 29  ? -24.32866 -29.41925 -12.72722 1.000 12.78755 ? 1488 GLY A HA2  1 
ATOM   434  H  HA3  . GLY A 1 29  ? -23.65770 -29.56452 -11.30484 1.000 12.78755 ? 1488 GLY A HA3  1 
ATOM   435  N  N    . THR A 1 30  ? -22.00226 -31.58011 -12.40854 1.000 11.18790 ? 1489 THR A N    1 
ATOM   436  C  CA   . THR A 1 30  ? -20.76164 -32.03453 -13.04531 1.000 11.10377 ? 1489 THR A CA   1 
ATOM   437  C  C    . THR A 1 30  ? -21.01086 -32.66629 -14.41429 1.000 11.28531 ? 1489 THR A C    1 
ATOM   438  O  O    . THR A 1 30  ? -20.13621 -32.60835 -15.28358 1.000 11.65641 ? 1489 THR A O    1 
ATOM   439  C  CB   . THR A 1 30  ? -19.91877 -32.93599 -12.14951 1.000 11.60905 ? 1489 THR A CB   1 
ATOM   440  O  OG1  . THR A 1 30  ? -20.61904 -34.13116 -11.83905 1.000 11.80380 ? 1489 THR A OG1  1 
ATOM   441  C  CG2  . THR A 1 30  ? -19.48905 -32.22796 -10.84514 1.000 12.35382 ? 1489 THR A CG2  1 
ATOM   442  H  H    . THR A 1 30  ? -22.32013 -32.10488 -11.80589 1.000 13.42548 ? 1489 THR A H    1 
ATOM   443  H  HA   . THR A 1 30  ? -20.20879 -31.24891 -13.17972 1.000 13.32452 ? 1489 THR A HA   1 
ATOM   444  H  HB   . THR A 1 30  ? -19.10955 -33.16064 -12.63488 1.000 13.93086 ? 1489 THR A HB   1 
ATOM   445  H  HG1  . THR A 1 30  ? -21.33197 -33.94939 -11.43372 1.000 14.16456 ? 1489 THR A HG1  1 
ATOM   446  H  HG21 . THR A 1 30  ? -18.96659 -32.83308 -10.29581 1.000 14.82459 ? 1489 THR A HG21 1 
ATOM   447  H  HG22 . THR A 1 30  ? -18.95148 -31.44770 -11.05278 1.000 14.82459 ? 1489 THR A HG22 1 
ATOM   448  H  HG23 . THR A 1 30  ? -20.27228 -31.94702 -10.34662 1.000 14.82459 ? 1489 THR A HG23 1 
ATOM   449  N  N    . ALA A 1 31  ? -22.19612 -33.21503 -14.64364 1.000 11.87748 ? 1490 ALA A N    1 
ATOM   450  C  CA   . ALA A 1 31  ? -22.60108 -33.55466 -16.00258 1.000 12.11170 ? 1490 ALA A CA   1 
ATOM   451  C  C    . ALA A 1 31  ? -22.62481 -32.30332 -16.87645 1.000 11.33796 ? 1490 ALA A C    1 
ATOM   452  O  O    . ALA A 1 31  ? -22.11305 -32.28979 -17.99334 1.000 10.49312 ? 1490 ALA A O    1 
ATOM   453  C  CB   . ALA A 1 31  ? -23.96075 -34.28801 -16.02801 1.000 12.65125 ? 1490 ALA A CB   1 
ATOM   454  H  H    . ALA A 1 31  ? -22.77894 -33.39960 -14.03878 1.000 14.25298 ? 1490 ALA A H    1 
ATOM   455  H  HA   . ALA A 1 31  ? -21.95426 -34.17772 -16.36907 1.000 14.53404 ? 1490 ALA A HA   1 
ATOM   456  H  HB1  . ALA A 1 31  ? -24.19865 -34.48035 -16.94851 1.000 15.18150 ? 1490 ALA A HB1  1 
ATOM   457  H  HB2  . ALA A 1 31  ? -23.88303 -35.11482 -15.52677 1.000 15.18150 ? 1490 ALA A HB2  1 
ATOM   458  H  HB3  . ALA A 1 31  ? -24.63430 -33.71855 -15.62435 1.000 15.18150 ? 1490 ALA A HB3  1 
ATOM   459  N  N    . ALA A 1 32  ? -23.22784 -31.23097 -16.35059 1.000 11.93278 ? 1491 ALA A N    1 
ATOM   460  C  CA   . ALA A 1 32  ? -23.24368 -29.94685 -17.04747 1.000 11.42477 ? 1491 ALA A CA   1 
ATOM   461  C  C    . ALA A 1 32  ? -21.81392 -29.44716 -17.31983 1.000 9.99573  ? 1491 ALA A C    1 
ATOM   462  O  O    . ALA A 1 32  ? -21.53805 -28.97918 -18.41299 1.000 10.25097 ? 1491 ALA A O    1 
ATOM   463  C  CB   . ALA A 1 32  ? -23.99532 -28.92195 -16.20454 1.000 10.91683 ? 1491 ALA A CB   1 
ATOM   464  H  H    . ALA A 1 32  ? -23.63394 -31.22259 -15.59256 1.000 14.31933 ? 1491 ALA A H    1 
ATOM   465  H  HA   . ALA A 1 32  ? -23.69952 -30.05338 -17.89703 1.000 13.70972 ? 1491 ALA A HA   1 
ATOM   466  H  HB1  . ALA A 1 32  ? -24.00408 -28.07284 -16.67340 1.000 13.10020 ? 1491 ALA A HB1  1 
ATOM   467  H  HB2  . ALA A 1 32  ? -24.90371 -29.23248 -16.06561 1.000 13.10020 ? 1491 ALA A HB2  1 
ATOM   468  H  HB3  . ALA A 1 32  ? -23.54510 -28.82385 -15.35097 1.000 13.10020 ? 1491 ALA A HB3  1 
ATOM   469  N  N    . ALA A 1 33  ? -20.92281 -29.57860 -16.33566 1.000 10.45100 ? 1492 ALA A N    1 
ATOM   470  C  CA   . ALA A 1 33  ? -19.52233 -29.18434 -16.55448 1.000 9.94045  ? 1492 ALA A CA   1 
ATOM   471  C  C    . ALA A 1 33  ? -18.91239 -29.94085 -17.71668 1.000 10.06941 ? 1492 ALA A C    1 
ATOM   472  O  O    . ALA A 1 33  ? -18.34354 -29.33293 -18.64173 1.000 10.72735 ? 1492 ALA A O    1 
ATOM   473  C  CB   . ALA A 1 33  ? -18.74724 -29.38612 -15.25931 1.000 10.43782 ? 1492 ALA A CB   1 
ATOM   474  H  H    . ALA A 1 33  ? -21.09443 -29.88495 -15.55062 1.000 12.54120 ? 1492 ALA A H    1 
ATOM   475  H  HA   . ALA A 1 33  ? -19.47297 -28.24371 -16.78618 1.000 11.92854 ? 1492 ALA A HA   1 
ATOM   476  H  HB1  . ALA A 1 33  ? -17.82264 -29.12952 -15.40135 1.000 12.52538 ? 1492 ALA A HB1  1 
ATOM   477  H  HB2  . ALA A 1 33  ? -19.14113 -28.83356 -14.56619 1.000 12.52538 ? 1492 ALA A HB2  1 
ATOM   478  H  HB3  . ALA A 1 33  ? -18.79572 -30.32083 -15.00462 1.000 12.52538 ? 1492 ALA A HB3  1 
ATOM   479  N  N    . LEU A 1 34  ? -19.02066 -31.27438 -17.70589 1.000 10.63786 ? 1493 LEU A N    1 
ATOM   480  C  CA   . LEU A 1 34  ? -18.37788 -32.06414 -18.76189 1.000 10.89846 ? 1493 LEU A CA   1 
ATOM   481  C  C    . LEU A 1 34  ? -18.92722 -31.68467 -20.13359 1.000 11.07481 ? 1493 LEU A C    1 
ATOM   482  O  O    . LEU A 1 34  ? -18.19181 -31.55726 -21.10969 1.000 11.30112 ? 1493 LEU A O    1 
ATOM   483  C  CB   . LEU A 1 34  ? -18.60075 -33.55941 -18.49075 1.000 12.21170 ? 1493 LEU A CB   1 
ATOM   484  C  CG   . LEU A 1 34  ? -17.84119 -34.11647 -17.29248 1.000 11.73806 ? 1493 LEU A CG   1 
ATOM   485  C  CD1  . LEU A 1 34  ? -18.31718 -35.50838 -16.96202 1.000 13.25131 ? 1493 LEU A CD1  1 
ATOM   486  C  CD2  . LEU A 1 34  ? -16.35688 -34.16244 -17.52812 1.000 12.52229 ? 1493 LEU A CD2  1 
ATOM   487  H  H    . LEU A 1 34  ? -19.44748 -31.73288 -17.11666 1.000 12.76543 ? 1493 LEU A H    1 
ATOM   488  H  HA   . LEU A 1 34  ? -17.42353 -31.89064 -18.75854 1.000 13.07816 ? 1493 LEU A HA   1 
ATOM   489  H  HB2  . LEU A 1 34  ? -19.54626 -33.70396 -18.32949 1.000 14.65404 ? 1493 LEU A HB2  1 
ATOM   490  H  HB3  . LEU A 1 34  ? -18.31756 -34.05818 -19.27301 1.000 14.65404 ? 1493 LEU A HB3  1 
ATOM   491  H  HG   . LEU A 1 34  ? -18.01250 -33.52054 -16.54655 1.000 14.08567 ? 1493 LEU A HG   1 
ATOM   492  H  HD11 . LEU A 1 34  ? -17.83014 -35.83341 -16.18868 1.000 15.90157 ? 1493 LEU A HD11 1 
ATOM   493  H  HD12 . LEU A 1 34  ? -19.26685 -35.47930 -16.76660 1.000 15.90157 ? 1493 LEU A HD12 1 
ATOM   494  H  HD13 . LEU A 1 34  ? -18.15366 -36.08708 -17.72312 1.000 15.90157 ? 1493 LEU A HD13 1 
ATOM   495  H  HD21 . LEU A 1 34  ? -15.93096 -34.60061 -16.77479 1.000 15.02675 ? 1493 LEU A HD21 1 
ATOM   496  H  HD22 . LEU A 1 34  ? -16.18164 -34.65968 -18.34233 1.000 15.02675 ? 1493 LEU A HD22 1 
ATOM   497  H  HD23 . LEU A 1 34  ? -16.02280 -33.25601 -17.61570 1.000 15.02675 ? 1493 LEU A HD23 1 
ATOM   498  N  N    . ALA A 1 35  ? -20.26185 -31.49230 -20.22551 1.000 12.45123 ? 1494 ALA A N    1 
ATOM   499  C  CA   . ALA A 1 35  ? -20.86514 -31.14720 -21.51175 1.000 13.05130 ? 1494 ALA A CA   1 
ATOM   500  C  C    . ALA A 1 35  ? -20.41007 -29.76005 -21.97993 1.000 12.59597 ? 1494 ALA A C    1 
ATOM   501  O  O    . ALA A 1 35  ? -20.50195 -29.45858 -23.16803 1.000 14.39354 ? 1494 ALA A O    1 
ATOM   502  C  CB   . ALA A 1 35  ? -22.36780 -31.11607 -21.36635 1.000 13.37500 ? 1494 ALA A CB   1 
ATOM   503  H  H    . ALA A 1 35  ? -20.81628 -31.55601 -19.57118 1.000 14.94147 ? 1494 ALA A H    1 
ATOM   504  H  HA   . ALA A 1 35  ? -20.61714 -31.81438 -22.17074 1.000 15.66157 ? 1494 ALA A HA   1 
ATOM   505  H  HB1  . ALA A 1 35  ? -22.76337 -30.89097 -22.22295 1.000 16.05000 ? 1494 ALA A HB1  1 
ATOM   506  H  HB2  . ALA A 1 35  ? -22.67548 -31.99007 -21.07937 1.000 16.05000 ? 1494 ALA A HB2  1 
ATOM   507  H  HB3  . ALA A 1 35  ? -22.60735 -30.44764 -20.70551 1.000 16.05000 ? 1494 ALA A HB3  1 
ATOM   508  N  N    . GLY A 1 36  ? -19.94641 -28.93205 -21.06191 1.000 11.63809 ? 1495 GLY A N    1 
ATOM   509  C  CA   . GLY A 1 36  ? -19.36199 -27.63585 -21.33479 1.000 11.70379 ? 1495 GLY A CA   1 
ATOM   510  C  C    . GLY A 1 36  ? -17.86344 -27.66613 -21.51325 1.000 11.79586 ? 1495 GLY A C    1 
ATOM   511  O  O    . GLY A 1 36  ? -17.24074 -26.60691 -21.62686 1.000 12.16699 ? 1495 GLY A O    1 
ATOM   512  H  H    . GLY A 1 36  ? -19.96065 -29.11100 -20.22085 1.000 13.96571 ? 1495 GLY A H    1 
ATOM   513  H  HA2  . GLY A 1 36  ? -19.75374 -27.27916 -22.14731 1.000 14.04455 ? 1495 GLY A HA2  1 
ATOM   514  H  HA3  . GLY A 1 36  ? -19.56436 -27.03837 -20.59793 1.000 14.04455 ? 1495 GLY A HA3  1 
ATOM   515  N  N    . GLY A 1 37  ? -17.24700 -28.85564 -21.57461 1.000 11.38539 ? 1496 GLY A N    1 
ATOM   516  C  CA   . GLY A 1 37  ? -15.80635 -28.95050 -21.74777 1.000 11.17470 ? 1496 GLY A CA   1 
ATOM   517  C  C    . GLY A 1 37  ? -14.98199 -28.65934 -20.52467 1.000 10.05110 ? 1496 GLY A C    1 
ATOM   518  O  O    . GLY A 1 37  ? -13.76795 -28.41458 -20.65966 1.000 11.99058 ? 1496 GLY A O    1 
ATOM   519  H  H    . GLY A 1 37  ? -17.64616 -29.61528 -21.51792 1.000 13.66246 ? 1496 GLY A H    1 
ATOM   520  H  HA2  . GLY A 1 37  ? -15.59038 -29.85046 -22.03817 1.000 13.40964 ? 1496 GLY A HA2  1 
ATOM   521  H  HA3  . GLY A 1 37  ? -15.53779 -28.32321 -22.43718 1.000 13.40964 ? 1496 GLY A HA3  1 
ATOM   522  N  N    . ILE A 1 38  ? -15.58950 -28.74053 -19.34745 1.000 10.54839 ? 1497 ILE A N    1 
ATOM   523  C  CA   . ILE A 1 38  ? -14.95257 -28.42534 -18.08042 1.000 10.99314 ? 1497 ILE A CA   1 
ATOM   524  C  C    . ILE A 1 38  ? -14.71292 -29.74269 -17.35180 1.000 10.45102 ? 1497 ILE A C    1 
ATOM   525  O  O    . ILE A 1 38  ? -15.66148 -30.52403 -17.12195 1.000 11.49059 ? 1497 ILE A O    1 
ATOM   526  C  CB   . ILE A 1 38  ? -15.88735 -27.49397 -17.27293 1.000 10.04317 ? 1497 ILE A CB   1 
ATOM   527  C  CG1  . ILE A 1 38  ? -16.17314 -26.17834 -17.91924 1.000 13.63555 ? 1497 ILE A CG1  1 
ATOM   528  C  CG2  . ILE A 1 38  ? -15.25039 -27.21344 -15.93044 1.000 10.41682 ? 1497 ILE A CG2  1 
ATOM   529  C  CD1  . ILE A 1 38  ? -15.11583 -25.39591 -18.45803 1.000 16.11475 ? 1497 ILE A CD1  1 
ATOM   530  H  H    . ILE A 1 38  ? -16.40816 -28.98741 -19.25558 1.000 12.65807 ? 1497 ILE A H    1 
ATOM   531  H  HA   . ILE A 1 38  ? -14.09070 -27.99859 -18.20678 1.000 13.19177 ? 1497 ILE A HA   1 
ATOM   532  H  HB   . ILE A 1 38  ? -16.73194 -27.96650 -17.20743 1.000 12.05180 ? 1497 ILE A HB   1 
ATOM   533  H  HG12 . ILE A 1 38  ? -16.78162 -26.34791 -18.65538 1.000 16.36266 ? 1497 ILE A HG12 1 
ATOM   534  H  HG13 . ILE A 1 38  ? -16.60522 -25.62085 -17.25335 1.000 16.36266 ? 1497 ILE A HG13 1 
ATOM   535  H  HG21 . ILE A 1 38  ? -15.81959 -26.60691 -15.43140 1.000 12.50018 ? 1497 ILE A HG21 1 
ATOM   536  H  HG22 . ILE A 1 38  ? -15.15241 -28.04849 -15.44671 1.000 12.50018 ? 1497 ILE A HG22 1 
ATOM   537  H  HG23 . ILE A 1 38  ? -14.38011 -26.80916 -16.07211 1.000 12.50018 ? 1497 ILE A HG23 1 
ATOM   538  H  HD11 . ILE A 1 38  ? -15.48638 -24.58586 -18.84196 1.000 19.33770 ? 1497 ILE A HD11 1 
ATOM   539  H  HD12 . ILE A 1 38  ? -14.49531 -25.17121 -17.74714 1.000 19.33770 ? 1497 ILE A HD12 1 
ATOM   540  H  HD13 . ILE A 1 38  ? -14.66108 -25.90915 -19.14409 1.000 19.33770 ? 1497 ILE A HD13 1 
ATOM   541  N  N    . THR A 1 39  ? -13.46128 -29.98488 -16.95619 1.000 10.71682 ? 1498 THR A N    1 
ATOM   542  C  CA   . THR A 1 39  ? -13.06569 -31.21616 -16.32785 1.000 9.99576  ? 1498 THR A CA   1 
ATOM   543  C  C    . THR A 1 39  ? -12.73365 -31.04736 -14.85993 1.000 9.53249  ? 1498 THR A C    1 
ATOM   544  O  O    . THR A 1 39  ? -12.53962 -32.06024 -14.15845 1.000 9.90881  ? 1498 THR A O    1 
ATOM   545  C  CB   . THR A 1 39  ? -11.88484 -31.87319 -17.07467 1.000 11.26949 ? 1498 THR A CB   1 
ATOM   546  O  OG1  . THR A 1 39  ? -10.79946 -30.95285 -17.15582 1.000 10.72474 ? 1498 THR A OG1  1 
ATOM   547  C  CG2  . THR A 1 39  ? -12.30062 -32.22401 -18.46772 1.000 12.26167 ? 1498 THR A CG2  1 
ATOM   548  H  H    . THR A 1 39  ? -12.81385 -29.42655 -17.04951 1.000 12.86018 ? 1498 THR A H    1 
ATOM   549  H  HA   . THR A 1 39  ? -13.80081 -31.84591 -16.39041 1.000 11.99491 ? 1498 THR A HA   1 
ATOM   550  H  HB   . THR A 1 39  ? -11.60724 -32.67416 -16.60319 1.000 13.52339 ? 1498 THR A HB   1 
ATOM   551  H  HG1  . THR A 1 39  ? -10.55088 -30.73301 -16.38415 1.000 12.86969 ? 1498 THR A HG1  1 
ATOM   552  H  HG21 . THR A 1 39  ? -11.57697 -32.68026 -18.92497 1.000 14.71401 ? 1498 THR A HG21 1 
ATOM   553  H  HG22 . THR A 1 39  ? -13.07596 -32.80648 -18.44578 1.000 14.71401 ? 1498 THR A HG22 1 
ATOM   554  H  HG23 . THR A 1 39  ? -12.52564 -31.41877 -18.95951 1.000 14.71401 ? 1498 THR A HG23 1 
ATOM   555  N  N    . MET A 1 40  ? -12.70685 -29.79038 -14.33134 1.000 10.07203 ? 1499 MET A N    1 
ATOM   556  C  CA   . MET A 1 40  ? -12.44702 -29.59180 -12.92288 1.000 9.61144  ? 1499 MET A CA   1 
ATOM   557  C  C    . MET A 1 40  ? -13.23455 -28.34664 -12.50288 1.000 8.83507  ? 1499 MET A C    1 
ATOM   558  O  O    . MET A 1 40  ? -13.20558 -27.33149 -13.21544 1.000 9.26136  ? 1499 MET A O    1 
ATOM   559  C  CB   . MET A 1 40  ? -10.91242 -29.42855 -12.64991 1.000 10.06673 ? 1499 MET A CB   1 
ATOM   560  C  CG   . MET A 1 40  ? -10.53968 -29.31216 -11.24240 1.000 10.41944 ? 1499 MET A CG   1 
ATOM   561  S  SD   . MET A 1 40  ? -8.87625  -28.74131 -10.88451 1.000 11.02725 ? 1499 MET A SD   1 
ATOM   562  C  CE   . MET A 1 40  ? -7.92356  -29.88731 -11.85800 1.000 12.55905 ? 1499 MET A CE   1 
ATOM   563  H  H    . MET A 1 40  ? -12.83642 -29.06754 -14.77890 1.000 12.08643 ? 1499 MET A H    1 
ATOM   564  H  HA   . MET A 1 40  ? -12.73935 -30.35171 -12.39565 1.000 11.53373 ? 1499 MET A HA   1 
ATOM   565  H  HB2  . MET A 1 40  ? -10.45353 -30.20443 -13.00813 1.000 12.08008 ? 1499 MET A HB2  1 
ATOM   566  H  HB3  . MET A 1 40  ? -10.60546 -28.62514 -13.09848 1.000 12.08008 ? 1499 MET A HB3  1 
ATOM   567  H  HG2  . MET A 1 40  ? -11.14913 -28.68553 -10.82192 1.000 12.50333 ? 1499 MET A HG2  1 
ATOM   568  H  HG3  . MET A 1 40  ? -10.63080 -30.18772 -10.83497 1.000 12.50333 ? 1499 MET A HG3  1 
ATOM   569  H  HE1  . MET A 1 40  ? -6.98348  -29.66050 -11.78244 1.000 15.07086 ? 1499 MET A HE1  1 
ATOM   570  H  HE2  . MET A 1 40  ? -8.07478  -30.78593 -11.52558 1.000 15.07086 ? 1499 MET A HE2  1 
ATOM   571  H  HE3  . MET A 1 40  ? -8.20536  -29.82542 -12.78409 1.000 15.07086 ? 1499 MET A HE3  1 
ATOM   572  N  N    . VAL A 1 41  ? -13.91670 -28.41438 -11.36838 1.000 9.41405  ? 1500 VAL A N    1 
ATOM   573  C  CA   . VAL A 1 41  ? -14.70081 -27.30050 -10.85934 1.000 9.56406  ? 1500 VAL A CA   1 
ATOM   574  C  C    . VAL A 1 41  ? -14.34110 -27.01215 -9.42806  1.000 9.38515  ? 1500 VAL A C    1 
ATOM   575  O  O    . VAL A 1 41  ? -14.01027 -27.92261 -8.66497  1.000 11.38791 ? 1500 VAL A O    1 
ATOM   576  C  CB   . VAL A 1 41  ? -16.23804 -27.57242 -10.98888 1.000 10.06675 ? 1500 VAL A CB   1 
ATOM   577  C  CG1  . VAL A 1 41  ? -16.65111 -27.69860 -12.42960 1.000 9.75620  ? 1500 VAL A CG1  1 
ATOM   578  C  CG2  . VAL A 1 41  ? -16.64711 -28.78822 -10.18221 1.000 12.17218 ? 1500 VAL A CG2  1 
ATOM   579  H  H    . VAL A 1 41  ? -13.94104 -29.11105 -10.86474 1.000 11.29686 ? 1500 VAL A H    1 
ATOM   580  H  HA   . VAL A 1 41  ? -14.47123 -26.51143 -11.37467 1.000 11.47688 ? 1500 VAL A HA   1 
ATOM   581  H  HB   . VAL A 1 41  ? -16.71307 -26.81031 -10.62223 1.000 12.08010 ? 1500 VAL A HB   1 
ATOM   582  H  HG11 . VAL A 1 41  ? -17.60643 -27.86150 -12.47113 1.000 11.70744 ? 1500 VAL A HG11 1 
ATOM   583  H  HG12 . VAL A 1 41  ? -16.43565 -26.87428 -12.89326 1.000 11.70744 ? 1500 VAL A HG12 1 
ATOM   584  H  HG13 . VAL A 1 41  ? -16.17142 -28.43950 -12.83193 1.000 11.70744 ? 1500 VAL A HG13 1 
ATOM   585  H  HG21 . VAL A 1 41  ? -17.57602 -28.99436 -10.37073 1.000 14.60662 ? 1500 VAL A HG21 1 
ATOM   586  H  HG22 . VAL A 1 41  ? -16.08452 -29.53754 -10.43304 1.000 14.60662 ? 1500 VAL A HG22 1 
ATOM   587  H  HG23 . VAL A 1 41  ? -16.53656 -28.59290 -9.23853  1.000 14.60662 ? 1500 VAL A HG23 1 
ATOM   588  N  N    . CYS A 1 42  ? -14.46089 -25.73809 -9.05027  1.000 9.48512  ? 1501 CYS A N    1 
ATOM   589  C  CA   . CYS A 1 42  ? -14.30301 -25.32779 -7.67645  1.000 9.40617  ? 1501 CYS A CA   1 
ATOM   590  C  C    . CYS A 1 42  ? -15.66764 -24.86137 -7.16895  1.000 9.32719  ? 1501 CYS A C    1 
ATOM   591  O  O    . CYS A 1 42  ? -16.22899 -23.87304 -7.69028  1.000 9.49560  ? 1501 CYS A O    1 
ATOM   592  C  CB   . CYS A 1 42  ? -13.24700 -24.23261 -7.48469  1.000 9.81415  ? 1501 CYS A CB   1 
ATOM   593  S  SG   . CYS A 1 42  ? -11.59694 -24.75515 -7.96825  1.000 11.59826 ? 1501 CYS A SG   1 
ATOM   594  H  H    . CYS A 1 42  ? -14.63634 -25.09119 -9.58910  1.000 11.38214 ? 1501 CYS A H    1 
ATOM   595  H  HA   . CYS A 1 42  ? -13.99960 -26.08977 -7.15855  1.000 11.28740 ? 1501 CYS A HA   1 
ATOM   596  H  HB2  . CYS A 1 42  ? -13.48843 -23.46463 -8.02581  1.000 11.77698 ? 1501 CYS A HB2  1 
ATOM   597  H  HB3  . CYS A 1 42  ? -13.21939 -23.98284 -6.54781  1.000 11.77698 ? 1501 CYS A HB3  1 
ATOM   598  H  HG   . CYS A 1 42  ? -10.83232 -23.84720 -7.79219  1.000 13.91791 ? 1501 CYS A HG   1 
ATOM   599  N  N    . ALA A 1 43  ? -16.21277 -25.58405 -6.18446  1.000 9.21137  ? 1502 ALA A N    1 
ATOM   600  C  CA   . ALA A 1 43  ? -17.59343 -25.40956 -5.74067  1.000 10.28786 ? 1502 ALA A CA   1 
ATOM   601  C  C    . ALA A 1 43  ? -17.69799 -24.47138 -4.54906  1.000 9.89304  ? 1502 ALA A C    1 
ATOM   602  O  O    . ALA A 1 43  ? -17.01752 -24.64092 -3.54456  1.000 10.11410 ? 1502 ALA A O    1 
ATOM   603  C  CB   . ALA A 1 43  ? -18.21264 -26.77032 -5.42463  1.000 11.31949 ? 1502 ALA A CB   1 
ATOM   604  H  H    . ALA A 1 43  ? -15.79015 -26.19463 -5.75066  1.000 11.05365 ? 1502 ALA A H    1 
ATOM   605  H  HA   . ALA A 1 43  ? -18.09774 -24.98448 -6.45192  1.000 12.34543 ? 1502 ALA A HA   1 
ATOM   606  H  HB1  . ALA A 1 43  ? -19.12767 -26.64018 -5.13019  1.000 13.58338 ? 1502 ALA A HB1  1 
ATOM   607  H  HB2  . ALA A 1 43  ? -18.19747 -27.31779 -6.22523  1.000 13.58338 ? 1502 ALA A HB2  1 
ATOM   608  H  HB3  . ALA A 1 43  ? -17.69670 -27.19666 -4.72254  1.000 13.58338 ? 1502 ALA A HB3  1 
ATOM   609  N  N    . MET A 1 44  ? -18.58260 -23.46793 -4.68474  1.000 9.55094  ? 1503 MET A N    1 
ATOM   610  C  CA   . MET A 1 44  ? -18.79230 -22.46179 -3.64320  1.000 8.84824  ? 1503 MET A CA   1 
ATOM   611  C  C    . MET A 1 44  ? -19.50063 -22.98605 -2.40777  1.000 9.79559  ? 1503 MET A C    1 
ATOM   612  O  O    . MET A 1 44  ? -20.19001 -24.01451 -2.47586  1.000 10.47735 ? 1503 MET A O    1 
ATOM   613  C  CB   . MET A 1 44  ? -19.48461 -21.20475 -4.18808  1.000 9.94823  ? 1503 MET A CB   1 
ATOM   614  C  CG   . MET A 1 44  ? -18.58289 -20.47195 -5.23478  1.000 9.66931  ? 1503 MET A CG   1 
ATOM   615  S  SD   . MET A 1 44  ? -17.21489 -19.72673 -4.28703  1.000 10.03503 ? 1503 MET A SD   1 
ATOM   616  C  CE   . MET A 1 44  ? -16.23722 -19.05276 -5.60456  1.000 10.27195 ? 1503 MET A CE   1 
ATOM   617  H  H    . MET A 1 44  ? -19.07614 -23.35085 -5.37923  1.000 11.46113 ? 1503 MET A H    1 
ATOM   618  H  HA   . MET A 1 44  ? -17.90602 -22.19651 -3.35160  1.000 10.61788 ? 1503 MET A HA   1 
ATOM   619  H  HB2  . MET A 1 44  ? -20.31501 -21.45701 -4.62133  1.000 11.93788 ? 1503 MET A HB2  1 
ATOM   620  H  HB3  . MET A 1 44  ? -19.66440 -20.59376 -3.45646  1.000 11.93788 ? 1503 MET A HB3  1 
ATOM   621  H  HG2  . MET A 1 44  ? -18.22859 -21.10246 -5.88117  1.000 11.60318 ? 1503 MET A HG2  1 
ATOM   622  H  HG3  . MET A 1 44  ? -19.08357 -19.77668 -5.68955  1.000 11.60318 ? 1503 MET A HG3  1 
ATOM   623  H  HE1  . MET A 1 44  ? -15.47771 -18.58306 -5.22583  1.000 12.32634 ? 1503 MET A HE1  1 
ATOM   624  H  HE2  . MET A 1 44  ? -15.92909 -19.77698 -6.17152  1.000 12.32634 ? 1503 MET A HE2  1 
ATOM   625  H  HE3  . MET A 1 44  ? -16.78265 -18.43822 -6.12007  1.000 12.32634 ? 1503 MET A HE3  1 
ATOM   626  N  N    . PRO A 1 45  ? -19.36109 -22.30694 -1.26672  1.000 9.46671  ? 1504 PRO A N    1 
ATOM   627  C  CA   . PRO A 1 45  ? -19.74443 -22.88255 0.03568   1.000 9.66141  ? 1504 PRO A CA   1 
ATOM   628  C  C    . PRO A 1 45  ? -21.11164 -22.43650 0.53116   1.000 9.66147  ? 1504 PRO A C    1 
ATOM   629  O  O    . PRO A 1 45  ? -21.43605 -22.74346 1.68508   1.000 10.54047 ? 1504 PRO A O    1 
ATOM   630  C  CB   . PRO A 1 45  ? -18.64867 -22.35703 0.96597   1.000 10.36152 ? 1504 PRO A CB   1 
ATOM   631  C  CG   . PRO A 1 45  ? -18.39994 -20.93451 0.38058   1.000 10.09043 ? 1504 PRO A CG   1 
ATOM   632  C  CD   . PRO A 1 45  ? -18.50738 -21.09249 -1.09829  1.000 9.48774  ? 1504 PRO A CD   1 
ATOM   633  H  HA   . PRO A 1 45  ? -19.69678 -23.85110 0.01246   1.000 11.59370 ? 1504 PRO A HA   1 
ATOM   634  H  HB2  . PRO A 1 45  ? -18.96433 -22.31879 1.88237   1.000 12.43382 ? 1504 PRO A HB2  1 
ATOM   635  H  HB3  . PRO A 1 45  ? -17.85523 -22.91234 0.91129   1.000 12.43382 ? 1504 PRO A HB3  1 
ATOM   636  H  HG2  . PRO A 1 45  ? -19.07298 -20.31969 0.71212   1.000 12.10852 ? 1504 PRO A HG2  1 
ATOM   637  H  HG3  . PRO A 1 45  ? -17.51553 -20.62514 0.63160   1.000 12.10852 ? 1504 PRO A HG3  1 
ATOM   638  H  HD2  . PRO A 1 45  ? -18.93210 -20.31656 -1.49635  1.000 11.38529 ? 1504 PRO A HD2  1 
ATOM   639  H  HD3  . PRO A 1 45  ? -17.63223 -21.23076 -1.49313  1.000 11.38529 ? 1504 PRO A HD3  1 
ATOM   640  N  N    . ASN A 1 46  ? -21.88741 -21.73729 -0.29039  1.000 10.14045 ? 1505 ASN A N    1 
ATOM   641  C  CA   . ASN A 1 46  ? -23.19431 -21.19467 0.15402   1.000 10.85105 ? 1505 ASN A CA   1 
ATOM   642  C  C    . ASN A 1 46  ? -24.32059 -22.18735 -0.00682  1.000 11.28536 ? 1505 ASN A C    1 
ATOM   643  O  O    . ASN A 1 46  ? -25.41363 -21.84429 -0.44651  1.000 11.60373 ? 1505 ASN A O    1 
ATOM   644  C  CB   . ASN A 1 46  ? -23.48647 -19.90318 -0.58911  1.000 11.09578 ? 1505 ASN A CB   1 
ATOM   645  C  CG   . ASN A 1 46  ? -23.68811 -20.08574 -2.07488  1.000 10.33789 ? 1505 ASN A CG   1 
ATOM   646  O  OD1  . ASN A 1 46  ? -23.21821 -21.06432 -2.67751  1.000 11.24587 ? 1505 ASN A OD1  1 
ATOM   647  N  ND2  . ASN A 1 46  ? -24.38461 -19.15526 -2.70021  1.000 11.50369 ? 1505 ASN A ND2  1 
ATOM   648  H  H    . ASN A 1 46  ? -21.69076 -21.55801 -1.10818  1.000 12.16855 ? 1505 ASN A H    1 
ATOM   649  H  HA   . ASN A 1 46  ? -23.13253 -20.99479 1.10119   1.000 13.02126 ? 1505 ASN A HA   1 
ATOM   650  H  HB2  . ASN A 1 46  ? -24.29665 -19.51146 -0.22709  1.000 13.31494 ? 1505 ASN A HB2  1 
ATOM   651  H  HB3  . ASN A 1 46  ? -22.74020 -19.29612 -0.46478  1.000 13.31494 ? 1505 ASN A HB3  1 
ATOM   652  H  HD21 . ASN A 1 46  ? -24.52419 -19.21852 -3.54644  1.000 13.80442 ? 1505 ASN A HD21 1 
ATOM   653  H  HD22 . ASN A 1 46  ? -24.69888 -18.48570 -2.26143  1.000 13.80442 ? 1505 ASN A HD22 1 
ATOM   654  N  N    . THR A 1 47  ? -24.05842 -23.41627 0.42046   1.000 11.62223 ? 1506 THR A N    1 
ATOM   655  C  CA   . THR A 1 47  ? -25.00433 -24.51645 0.47447   1.000 11.42750 ? 1506 THR A CA   1 
ATOM   656  C  C    . THR A 1 47  ? -25.78530 -24.47880 1.77781   1.000 12.31444 ? 1506 THR A C    1 
ATOM   657  O  O    . THR A 1 47  ? -25.67637 -23.55669 2.59446   1.000 13.61711 ? 1506 THR A O    1 
ATOM   658  C  CB   . THR A 1 47  ? -24.23754 -25.82171 0.28561   1.000 12.44335 ? 1506 THR A CB   1 
ATOM   659  O  OG1  . THR A 1 47  ? -23.15920 -25.89116 1.21008   1.000 13.03291 ? 1506 THR A OG1  1 
ATOM   660  C  CG2  . THR A 1 47  ? -23.68431 -25.93647 -1.11442  1.000 13.14342 ? 1506 THR A CG2  1 
ATOM   661  H  H    . THR A 1 47  ? -23.28209 -23.65309 0.70475   1.000 13.94668 ? 1506 THR A H    1 
ATOM   662  H  HA   . THR A 1 47  ? -25.65053 -24.41774 -0.24217  1.000 13.71300 ? 1506 THR A HA   1 
ATOM   663  H  HB   . THR A 1 47  ? -24.84798 -26.56058 0.43506   1.000 14.93202 ? 1506 THR A HB   1 
ATOM   664  H  HG1  . THR A 1 47  ? -23.45226 -25.85588 1.99651   1.000 15.63950 ? 1506 THR A HG1  1 
ATOM   665  H  HG21 . THR A 1 47  ? -23.21180 -26.77743 -1.21653  1.000 15.77210 ? 1506 THR A HG21 1 
ATOM   666  H  HG22 . THR A 1 47  ? -24.40685 -25.90088 -1.76062  1.000 15.77210 ? 1506 THR A HG22 1 
ATOM   667  H  HG23 . THR A 1 47  ? -23.06956 -25.20676 -1.28907  1.000 15.77210 ? 1506 THR A HG23 1 
ATOM   668  N  N    . ARG A 1 48  ? -26.61041 -25.51052 2.00114   1.000 14.17258 ? 1507 ARG A N    1 
ATOM   669  C  CA   . ARG A 1 48  ? -27.41782 -25.65837 3.22001   1.000 17.10441 ? 1507 ARG A CA   1 
ATOM   670  C  C    . ARG A 1 48  ? -27.20048 -27.05826 3.78742   1.000 17.04130 ? 1507 ARG A C    1 
ATOM   671  O  O    . ARG A 1 48  ? -27.78400 -28.03018 3.27029   1.000 18.69935 ? 1507 ARG A O    1 
ATOM   672  C  CB   . ARG A 1 48  ? -28.90354 -25.38811 2.92982   1.000 19.33616 ? 1507 ARG A CB   1 
ATOM   673  H  H    . ARG A 1 48  ? -26.72260 -26.15645 1.44456   1.000 17.00710 ? 1507 ARG A H    1 
ATOM   674  H  HA   . ARG A 1 48  ? -27.12334 -25.02036 3.88867   1.000 20.52529 ? 1507 ARG A HA   1 
ATOM   675  N  N    . PRO A 1 49  ? -26.41674 -27.23230 4.85354   1.000 18.10461 ? 1508 PRO A N    1 
ATOM   676  C  CA   . PRO A 1 49  ? -25.66699 -26.21406 5.62332   1.000 17.48345 ? 1508 PRO A CA   1 
ATOM   677  C  C    . PRO A 1 49  ? -24.55522 -25.59589 4.77039   1.000 15.62005 ? 1508 PRO A C    1 
ATOM   678  O  O    . PRO A 1 49  ? -24.02264 -26.22739 3.86170   1.000 15.15950 ? 1508 PRO A O    1 
ATOM   679  C  CB   . PRO A 1 49  ? -25.07514 -27.03380 6.76683   1.000 19.70996 ? 1508 PRO A CB   1 
ATOM   680  C  CG   . PRO A 1 49  ? -24.89200 -28.43153 6.22185   1.000 20.62321 ? 1508 PRO A CG   1 
ATOM   681  C  CD   . PRO A 1 49  ? -26.06139 -28.62481 5.22892   1.000 20.30740 ? 1508 PRO A CD   1 
ATOM   682  H  HA   . PRO A 1 49  ? -26.26130 -25.53142 5.97219   1.000 20.98014 ? 1508 PRO A HA   1 
ATOM   683  H  HB2  . PRO A 1 49  ? -24.22335 -26.65421 7.03378   1.000 23.65195 ? 1508 PRO A HB2  1 
ATOM   684  H  HB3  . PRO A 1 49  ? -25.68797 -27.03520 7.51872   1.000 23.65195 ? 1508 PRO A HB3  1 
ATOM   685  H  HG2  . PRO A 1 49  ? -24.03679 -28.50121 5.76947   1.000 24.74785 ? 1508 PRO A HG2  1 
ATOM   686  H  HG3  . PRO A 1 49  ? -24.93889 -29.07738 6.94405   1.000 24.74785 ? 1508 PRO A HG3  1 
ATOM   687  H  HD2  . PRO A 1 49  ? -25.77576 -29.13053 4.45203   1.000 24.36888 ? 1508 PRO A HD2  1 
ATOM   688  H  HD3  . PRO A 1 49  ? -26.80945 -29.06936 5.65750   1.000 24.36888 ? 1508 PRO A HD3  1 
ATOM   689  N  N    . PRO A 1 50  ? -24.18197 -24.33913 5.05755   1.000 14.94367 ? 1509 PRO A N    1 
ATOM   690  C  CA   . PRO A 1 50  ? -23.03151 -23.74259 4.34997   1.000 12.94088 ? 1509 PRO A CA   1 
ATOM   691  C  C    . PRO A 1 50  ? -21.72387 -24.35808 4.82106   1.000 12.37233 ? 1509 PRO A C    1 
ATOM   692  O  O    . PRO A 1 50  ? -21.62038 -24.80874 5.95201   1.000 13.07235 ? 1509 PRO A O    1 
ATOM   693  C  CB   . PRO A 1 50  ? -23.12778 -22.26335 4.72438   1.000 15.05156 ? 1509 PRO A CB   1 
ATOM   694  C  CG   . PRO A 1 50  ? -23.79488 -22.24790 6.07321   1.000 17.00959 ? 1509 PRO A CG   1 
ATOM   695  C  CD   . PRO A 1 50  ? -24.78844 -23.40038 6.02082   1.000 15.91481 ? 1509 PRO A CD   1 
ATOM   696  H  HA   . PRO A 1 50  ? -23.11056 -23.84034 3.38815   1.000 15.52906 ? 1509 PRO A HA   1 
ATOM   697  H  HB2  . PRO A 1 50  ? -22.23978 -21.87589 4.77149   1.000 18.06187 ? 1509 PRO A HB2  1 
ATOM   698  H  HB3  . PRO A 1 50  ? -23.66177 -21.79018 4.06722   1.000 18.06187 ? 1509 PRO A HB3  1 
ATOM   699  H  HG2  . PRO A 1 50  ? -23.13627 -22.38715 6.77159   1.000 20.41151 ? 1509 PRO A HG2  1 
ATOM   700  H  HG3  . PRO A 1 50  ? -24.24943 -21.40194 6.20976   1.000 20.41151 ? 1509 PRO A HG3  1 
ATOM   701  H  HD2  . PRO A 1 50  ? -24.88095 -23.81461 6.89303   1.000 19.09777 ? 1509 PRO A HD2  1 
ATOM   702  H  HD3  . PRO A 1 50  ? -25.65328 -23.09479 5.70527   1.000 19.09777 ? 1509 PRO A HD3  1 
ATOM   703  N  N    . ILE A 1 51  ? -20.72560 -24.32976 3.94605   1.000 11.78276 ? 1510 ILE A N    1 
ATOM   704  C  CA   . ILE A 1 51  ? -19.44175 -25.03354 4.21701   1.000 11.84326 ? 1510 ILE A CA   1 
ATOM   705  C  C    . ILE A 1 51  ? -18.55017 -24.04693 4.97272   1.000 11.98287 ? 1510 ILE A C    1 
ATOM   706  O  O    . ILE A 1 51  ? -17.62234 -23.44970 4.41561   1.000 12.82232 ? 1510 ILE A O    1 
ATOM   707  C  CB   . ILE A 1 51  ? -18.82924 -25.58198 2.94979   1.000 11.80389 ? 1510 ILE A CB   1 
ATOM   708  C  CG1  . ILE A 1 51  ? -19.84615 -26.30579 2.08513   1.000 14.03294 ? 1510 ILE A CG1  1 
ATOM   709  C  CG2  . ILE A 1 51  ? -17.64924 -26.43986 3.29271   1.000 12.68283 ? 1510 ILE A CG2  1 
ATOM   710  C  CD1  . ILE A 1 51  ? -20.67027 -27.34309 2.79571   1.000 13.75932 ? 1510 ILE A CD1  1 
ATOM   711  H  H    . ILE A 1 51  ? -20.75108 -23.91849 3.19119   1.000 14.13931 ? 1510 ILE A H    1 
ATOM   712  H  HA   . ILE A 1 51  ? -19.60132 -25.77857 4.81731   1.000 14.21191 ? 1510 ILE A HA   1 
ATOM   713  H  HB   . ILE A 1 51  ? -18.51942 -24.83676 2.41167   1.000 14.16467 ? 1510 ILE A HB   1 
ATOM   714  H  HG12 . ILE A 1 51  ? -20.45950 -25.64926 1.71953   1.000 16.83953 ? 1510 ILE A HG12 1 
ATOM   715  H  HG13 . ILE A 1 51  ? -19.37310 -26.75409 1.36670   1.000 16.83953 ? 1510 ILE A HG13 1 
ATOM   716  H  HG21 . ILE A 1 51  ? -17.31111 -26.85066 2.48165   1.000 15.21940 ? 1510 ILE A HG21 1 
ATOM   717  H  HG22 . ILE A 1 51  ? -16.96183 -25.88557 3.69413   1.000 15.21940 ? 1510 ILE A HG22 1 
ATOM   718  H  HG23 . ILE A 1 51  ? -17.92880 -27.12568 3.91913   1.000 15.21940 ? 1510 ILE A HG23 1 
ATOM   719  H  HD11 . ILE A 1 51  ? -21.18446 -27.84083 2.14090   1.000 16.51118 ? 1510 ILE A HD11 1 
ATOM   720  H  HD12 . ILE A 1 51  ? -20.07783 -27.94242 3.27605   1.000 16.51118 ? 1510 ILE A HD12 1 
ATOM   721  H  HD13 . ILE A 1 51  ? -21.26787 -26.89974 3.41797   1.000 16.51118 ? 1510 ILE A HD13 1 
ATOM   722  N  N    . ILE A 1 52  ? -18.80213 -23.89314 6.26761   1.000 13.51978 ? 1511 ILE A N    1 
ATOM   723  C  CA   . ILE A 1 52  ? -18.17389 -22.86627 7.09190   1.000 13.81725 ? 1511 ILE A CA   1 
ATOM   724  C  C    . ILE A 1 52  ? -17.50613 -23.46097 8.32584   1.000 14.13040 ? 1511 ILE A C    1 
ATOM   725  O  O    . ILE A 1 52  ? -17.05245 -22.73490 9.21101   1.000 14.51205 ? 1511 ILE A O    1 
ATOM   726  C  CB   . ILE A 1 52  ? -19.19618 -21.79350 7.47824   1.000 14.76738 ? 1511 ILE A CB   1 
ATOM   727  C  CG1  . ILE A 1 52  ? -20.36520 -22.38085 8.28721   1.000 16.85965 ? 1511 ILE A CG1  1 
ATOM   728  C  CG2  . ILE A 1 52  ? -19.64142 -21.01132 6.25349   1.000 16.37535 ? 1511 ILE A CG2  1 
ATOM   729  C  CD1  . ILE A 1 52  ? -21.18093 -21.28808 8.95084   1.000 18.41768 ? 1511 ILE A CD1  1 
ATOM   730  H  H    . ILE A 1 52  ? -19.35158 -24.38730 6.70750   1.000 16.22373 ? 1511 ILE A H    1 
ATOM   731  H  HA   . ILE A 1 52  ? -17.46168 -22.46307 6.57124   1.000 16.58070 ? 1511 ILE A HA   1 
ATOM   732  H  HB   . ILE A 1 52  ? -18.76327 -21.16160 8.07338   1.000 17.72086 ? 1511 ILE A HB   1 
ATOM   733  H  HG12 . ILE A 1 52  ? -20.94763 -22.88029 7.69371   1.000 20.23158 ? 1511 ILE A HG12 1 
ATOM   734  H  HG13 . ILE A 1 52  ? -20.01604 -22.96504 8.97838   1.000 20.23158 ? 1511 ILE A HG13 1 
ATOM   735  H  HG21 . ILE A 1 52  ? -20.24125 -20.30198 6.53267   1.000 19.65042 ? 1511 ILE A HG21 1 
ATOM   736  H  HG22 . ILE A 1 52  ? -18.86083 -20.63279 5.81957   1.000 19.65042 ? 1511 ILE A HG22 1 
ATOM   737  H  HG23 . ILE A 1 52  ? -20.09971 -21.61164 5.64481   1.000 19.65042 ? 1511 ILE A HG23 1 
ATOM   738  H  HD11 . ILE A 1 52  ? -21.82666 -21.69526 9.54929   1.000 22.10121 ? 1511 ILE A HD11 1 
ATOM   739  H  HD12 . ILE A 1 52  ? -20.58511 -20.70910 9.45152   1.000 22.10121 ? 1511 ILE A HD12 1 
ATOM   740  H  HD13 . ILE A 1 52  ? -21.64061 -20.77722 8.26628   1.000 22.10121 ? 1511 ILE A HD13 1 
ATOM   741  N  N    A ASP A 1 53  ? -17.48061 -24.78877 8.42017   0.365 14.34887 ? 1512 ASP A N    1 
ATOM   742  N  N    B ASP A 1 53  ? -17.46787 -24.79385 8.39770   0.635 13.74620 ? 1512 ASP A N    1 
ATOM   743  C  CA   A ASP A 1 53  ? -16.76393 -25.42953 9.51991   0.365 15.17788 ? 1512 ASP A CA   1 
ATOM   744  C  CA   B ASP A 1 53  ? -16.86905 -25.46495 9.55133   0.635 14.80416 ? 1512 ASP A CA   1 
ATOM   745  C  C    A ASP A 1 53  ? -16.40453 -26.85232 9.11183   0.365 15.35162 ? 1512 ASP A C    1 
ATOM   746  C  C    B ASP A 1 53  ? -16.41272 -26.85750 9.11390   0.635 14.70158 ? 1512 ASP A C    1 
ATOM   747  O  O    A ASP A 1 53  ? -16.79913 -27.32967 8.04668   0.365 15.44372 ? 1512 ASP A O    1 
ATOM   748  O  O    B ASP A 1 53  ? -16.71926 -27.30569 8.00723   0.635 15.00156 ? 1512 ASP A O    1 
ATOM   749  C  CB   A ASP A 1 53  ? -17.55093 -25.38364 10.83456  0.365 15.79902 ? 1512 ASP A CB   1 
ATOM   750  C  CB   B ASP A 1 53  ? -17.85874 -25.53326 10.71994  0.635 16.53067 ? 1512 ASP A CB   1 
ATOM   751  C  CG   A ASP A 1 53  ? -18.81480 -26.21965 10.80306  0.365 16.44118 ? 1512 ASP A CG   1 
ATOM   752  C  CG   B ASP A 1 53  ? -19.21167 -26.06137 10.28871  0.635 18.12288 ? 1512 ASP A CG   1 
ATOM   753  O  OD1  A ASP A 1 53  ? -19.06562 -26.94650 9.81503   0.365 16.83864 ? 1512 ASP A OD1  1 
ATOM   754  O  OD1  B ASP A 1 53  ? -19.26225 -27.23857 9.95429   0.635 16.29655 ? 1512 ASP A OD1  1 
ATOM   755  O  OD2  A ASP A 1 53  ? -19.56676 -26.11058 11.78361  0.365 16.47276 ? 1512 ASP A OD2  1 
ATOM   756  O  OD2  B ASP A 1 53  ? -20.20892 -25.29402 10.26255  0.635 19.39939 ? 1512 ASP A OD2  1 
ATOM   757  H  H    A ASP A 1 53  ? -17.86274 -25.32923 7.87110   0.365 17.21864 ? 1512 ASP A H    1 
ATOM   758  H  H    B ASP A 1 53  ? -17.77896 -25.32497 7.79709   0.635 16.49544 ? 1512 ASP A H    1 
ATOM   759  H  HA   A ASP A 1 53  ? -15.93398 -24.95080 9.67125   0.365 18.21346 ? 1512 ASP A HA   1 
ATOM   760  H  HA   B ASP A 1 53  ? -16.08596 -24.97550 9.84815   0.635 17.76499 ? 1512 ASP A HA   1 
ATOM   761  H  HB2  A ASP A 1 53  ? -16.98857 -25.72032 11.54960  0.365 18.95883 ? 1512 ASP A HB2  1 
ATOM   762  H  HB2  B ASP A 1 53  ? -17.50586 -26.12532 11.40247  0.635 19.83680 ? 1512 ASP A HB2  1 
ATOM   763  H  HB3  A ASP A 1 53  ? -17.80531 -24.46552 11.01687  0.365 18.95883 ? 1512 ASP A HB3  1 
ATOM   764  H  HB3  B ASP A 1 53  ? -17.98318 -24.64318 11.08487  0.635 19.83680 ? 1512 ASP A HB3  1 
ATOM   765  N  N    . ALA A 1 54  ? -15.61781 -27.51702 9.95794   1.000 16.33847 ? 1513 ALA A N    1 
ATOM   766  C  CA   . ALA A 1 54  ? -15.05788 -28.80887 9.56935   1.000 16.00957 ? 1513 ALA A CA   1 
ATOM   767  C  C    . ALA A 1 54  ? -16.14388 -29.87280 9.37695   1.000 15.85430 ? 1513 ALA A C    1 
ATOM   768  O  O    . ALA A 1 54  ? -16.06342 -30.62747 8.39054   1.000 16.27275 ? 1513 ALA A O    1 
ATOM   769  C  CB   . ALA A 1 54  ? -14.00884 -29.23845 10.61310  1.000 16.72541 ? 1513 ALA A CB   1 
ATOM   770  H  H    . ALA A 1 54  ? -15.39477 -27.24190 10.74162  1.000 19.60616 ? 1513 ALA A H    1 
ATOM   771  H  HA   . ALA A 1 54  ? -14.59858 -28.71473 8.72019   1.000 19.21149 ? 1513 ALA A HA   1 
ATOM   772  H  HB1  . ALA A 1 54  ? -13.68679 -30.12591 10.39039  1.000 20.07049 ? 1513 ALA A HB1  1 
ATOM   773  H  HB2  . ALA A 1 54  ? -13.27301 -28.60656 10.59985  1.000 20.07049 ? 1513 ALA A HB2  1 
ATOM   774  H  HB3  . ALA A 1 54  ? -14.42173 -29.24700 11.49080  1.000 20.07049 ? 1513 ALA A HB3  1 
ATOM   775  N  N    . PRO A 1 55  ? -17.16070 -29.97515 10.22592  1.000 15.09111 ? 1514 PRO A N    1 
ATOM   776  C  CA   . PRO A 1 55  ? -18.19748 -30.99008 9.97146   1.000 15.36210 ? 1514 PRO A CA   1 
ATOM   777  C  C    . PRO A 1 55  ? -18.90678 -30.78691 8.64260   1.000 14.52780 ? 1514 PRO A C    1 
ATOM   778  O  O    . PRO A 1 55  ? -19.16075 -31.75979 7.94038   1.000 14.07778 ? 1514 PRO A O    1 
ATOM   779  C  CB   . PRO A 1 55  ? -19.13695 -30.83911 11.17896  1.000 15.57268 ? 1514 PRO A CB   1 
ATOM   780  C  CG   . PRO A 1 55  ? -18.29371 -30.28197 12.26110  1.000 17.79389 ? 1514 PRO A CG   1 
ATOM   781  C  CD   . PRO A 1 55  ? -17.31186 -29.36833 11.55228  1.000 15.98327 ? 1514 PRO A CD   1 
ATOM   782  H  HA   . PRO A 1 55  ? -17.81267 -31.88028 9.99083   1.000 18.43452 ? 1514 PRO A HA   1 
ATOM   783  H  HB2  . PRO A 1 55  ? -19.86186 -30.23354 10.95829  1.000 18.68722 ? 1514 PRO A HB2  1 
ATOM   784  H  HB3  . PRO A 1 55  ? -19.49329 -31.70591 11.42914  1.000 18.68722 ? 1514 PRO A HB3  1 
ATOM   785  H  HG2  . PRO A 1 55  ? -18.84284 -29.78393 12.88665  1.000 21.35267 ? 1514 PRO A HG2  1 
ATOM   786  H  HG3  . PRO A 1 55  ? -17.83084 -30.99825 12.72326  1.000 21.35267 ? 1514 PRO A HG3  1 
ATOM   787  H  HD2  . PRO A 1 55  ? -17.67045 -28.46999 11.47955  1.000 19.17992 ? 1514 PRO A HD2  1 
ATOM   788  H  HD3  . PRO A 1 55  ? -16.46210 -29.34953 12.01966  1.000 19.17992 ? 1514 PRO A HD3  1 
ATOM   789  N  N    . ALA A 1 56  ? -19.20358 -29.54323 8.27388   1.000 13.53302 ? 1515 ALA A N    1 
ATOM   790  C  CA   . ALA A 1 56  ? -19.88661 -29.31234 6.99923   1.000 13.65139 ? 1515 ALA A CA   1 
ATOM   791  C  C    . ALA A 1 56  ? -18.99258 -29.65210 5.81440   1.000 13.15664 ? 1515 ALA A C    1 
ATOM   792  O  O    . ALA A 1 56  ? -19.45493 -30.18642 4.81075   1.000 13.63559 ? 1515 ALA A O    1 
ATOM   793  C  CB   . ALA A 1 56  ? -20.38197 -27.86113 6.93851   1.000 14.49881 ? 1515 ALA A CB   1 
ATOM   794  H  H    . ALA A 1 56  ? -19.02697 -28.83454 8.72793   1.000 16.23962 ? 1515 ALA A H    1 
ATOM   795  H  HA   . ALA A 1 56  ? -20.66203 -29.89219 6.94095   1.000 16.38167 ? 1515 ALA A HA   1 
ATOM   796  H  HB1  . ALA A 1 56  ? -20.83030 -27.71569 6.09073   1.000 17.39858 ? 1515 ALA A HB1  1 
ATOM   797  H  HB2  . ALA A 1 56  ? -21.00002 -27.70754 7.67017   1.000 17.39858 ? 1515 ALA A HB2  1 
ATOM   798  H  HB3  . ALA A 1 56  ? -19.62139 -27.26427 7.01716   1.000 17.39858 ? 1515 ALA A HB3  1 
ATOM   799  N  N    . LEU A 1 57  ? -17.69181 -29.30375 5.90208   1.000 13.43030 ? 1516 LEU A N    1 
ATOM   800  C  CA   . LEU A 1 57  ? -16.76405 -29.68161 4.86556   1.000 13.80146 ? 1516 LEU A CA   1 
ATOM   801  C  C    . LEU A 1 57  ? -16.65709 -31.20775 4.74377   1.000 13.55403 ? 1516 LEU A C    1 
ATOM   802  O  O    . LEU A 1 57  ? -16.62798 -31.73938 3.62670   1.000 13.27767 ? 1516 LEU A O    1 
ATOM   803  C  CB   . LEU A 1 57  ? -15.41012 -29.06972 5.15126   1.000 14.35146 ? 1516 LEU A CB   1 
ATOM   804  C  CG   . LEU A 1 57  ? -14.31191 -29.39239 4.12486   1.000 15.31477 ? 1516 LEU A CG   1 
ATOM   805  C  CD1  . LEU A 1 57  ? -14.64935 -28.86226 2.73782   1.000 16.34117 ? 1516 LEU A CD1  1 
ATOM   806  C  CD2  . LEU A 1 57  ? -12.98352 -28.86106 4.59926   1.000 16.13584 ? 1516 LEU A CD2  1 
ATOM   807  H  H    . LEU A 1 57  ? -17.34413 -28.85560 6.54851   1.000 16.11636 ? 1516 LEU A H    1 
ATOM   808  H  HA   . LEU A 1 57  ? -17.07936 -29.33943 4.01445   1.000 16.56175 ? 1516 LEU A HA   1 
ATOM   809  H  HB2  . LEU A 1 57  ? -15.51032 -28.10520 5.17513   1.000 17.22175 ? 1516 LEU A HB2  1 
ATOM   810  H  HB3  . LEU A 1 57  ? -15.10520 -29.39303 6.01346   1.000 17.22175 ? 1516 LEU A HB3  1 
ATOM   811  H  HG   . LEU A 1 57  ? -14.24653 -30.35665 4.04217   1.000 18.37772 ? 1516 LEU A HG   1 
ATOM   812  H  HD11 . LEU A 1 57  ? -13.89685 -29.02205 2.14697   1.000 19.60940 ? 1516 LEU A HD11 1 
ATOM   813  H  HD12 . LEU A 1 57  ? -15.43477 -29.32444 2.40554   1.000 19.60940 ? 1516 LEU A HD12 1 
ATOM   814  H  HD13 . LEU A 1 57  ? -14.82639 -27.91045 2.79797   1.000 19.60940 ? 1516 LEU A HD13 1 
ATOM   815  H  HD21 . LEU A 1 57  ? -12.30484 -29.07278 3.93937   1.000 19.36301 ? 1516 LEU A HD21 1 
ATOM   816  H  HD22 . LEU A 1 57  ? -13.04914 -27.89958 4.70951   1.000 19.36301 ? 1516 LEU A HD22 1 
ATOM   817  H  HD23 . LEU A 1 57  ? -12.76165 -29.27684 5.44707   1.000 19.36301 ? 1516 LEU A HD23 1 
ATOM   818  N  N    . ALA A 1 58  ? -16.63199 -31.91657 5.87447   1.000 13.94619 ? 1517 ALA A N    1 
ATOM   819  C  CA   . ALA A 1 58  ? -16.53176 -33.38260 5.81218   1.000 14.25671 ? 1517 ALA A CA   1 
ATOM   820  C  C    . ALA A 1 58  ? -17.74717 -33.96704 5.09494   1.000 12.73289 ? 1517 ALA A C    1 
ATOM   821  O  O    . ALA A 1 58  ? -17.62127 -34.88388 4.29025   1.000 13.08553 ? 1517 ALA A O    1 
ATOM   822  C  CB   . ALA A 1 58  ? -16.44042 -33.94362 7.21353   1.000 15.53315 ? 1517 ALA A CB   1 
ATOM   823  H  H    . ALA A 1 58  ? -16.67020 -31.58707 6.66793   1.000 16.73543 ? 1517 ALA A H    1 
ATOM   824  H  HA   . ALA A 1 58  ? -15.72987 -33.63283 5.32715   1.000 17.10805 ? 1517 ALA A HA   1 
ATOM   825  H  HB1  . ALA A 1 58  ? -16.36511 -34.90936 7.16279   1.000 18.63979 ? 1517 ALA A HB1  1 
ATOM   826  H  HB2  . ALA A 1 58  ? -15.65814 -33.57339 7.65155   1.000 18.63979 ? 1517 ALA A HB2  1 
ATOM   827  H  HB3  . ALA A 1 58  ? -17.24080 -33.69958 7.70419   1.000 18.63979 ? 1517 ALA A HB3  1 
ATOM   828  N  N    . LEU A 1 59  ? -18.95142 -33.44619 5.40258   1.000 12.94080 ? 1518 LEU A N    1 
ATOM   829  C  CA   . LEU A 1 59  ? -20.15427 -33.88681 4.72360   1.000 13.00927 ? 1518 LEU A CA   1 
ATOM   830  C  C    . LEU A 1 59  ? -20.07830 -33.60354 3.23787   1.000 12.93025 ? 1518 LEU A C    1 
ATOM   831  O  O    . LEU A 1 59  ? -20.31817 -34.47684 2.41057   1.000 13.44085 ? 1518 LEU A O    1 
ATOM   832  C  CB   . LEU A 1 59  ? -21.38472 -33.19725 5.31467   1.000 14.05408 ? 1518 LEU A CB   1 
ATOM   833  C  CG   . LEU A 1 59  ? -22.68815 -33.37672 4.53939   1.000 15.36216 ? 1518 LEU A CG   1 
ATOM   834  C  CD1  . LEU A 1 59  ? -23.10542 -34.84060 4.55143   1.000 16.30959 ? 1518 LEU A CD1  1 
ATOM   835  C  CD2  . LEU A 1 59  ? -23.78857 -32.44273 5.10653   1.000 17.07013 ? 1518 LEU A CD2  1 
ATOM   836  H  H    . LEU A 1 59  ? -19.08458 -32.84088 5.99879   1.000 15.52896 ? 1518 LEU A H    1 
ATOM   837  H  HA   . LEU A 1 59  ? -20.24201 -34.84351 4.85748   1.000 15.61112 ? 1518 LEU A HA   1 
ATOM   838  H  HB2  . LEU A 1 59  ? -21.52993 -33.54977 6.20660   1.000 16.86490 ? 1518 LEU A HB2  1 
ATOM   839  H  HB3  . LEU A 1 59  ? -21.20567 -32.24497 5.35939   1.000 16.86490 ? 1518 LEU A HB3  1 
ATOM   840  H  HG   . LEU A 1 59  ? -22.56094 -33.12475 3.61137   1.000 18.43460 ? 1518 LEU A HG   1 
ATOM   841  H  HD11 . LEU A 1 59  ? -23.95844 -34.92957 4.09827   1.000 19.57150 ? 1518 LEU A HD11 1 
ATOM   842  H  HD12 . LEU A 1 59  ? -22.43076 -35.36508 4.09246   1.000 19.57150 ? 1518 LEU A HD12 1 
ATOM   843  H  HD13 . LEU A 1 59  ? -23.18678 -35.13824 5.47104   1.000 19.57150 ? 1518 LEU A HD13 1 
ATOM   844  H  HD21 . LEU A 1 59  ? -24.60596 -32.57456 4.60117   1.000 20.48416 ? 1518 LEU A HD21 1 
ATOM   845  H  HD22 . LEU A 1 59  ? -23.93784 -32.66095 6.03980   1.000 20.48416 ? 1518 LEU A HD22 1 
ATOM   846  H  HD23 . LEU A 1 59  ? -23.49418 -31.52207 5.02509   1.000 20.48416 ? 1518 LEU A HD23 1 
ATOM   847  N  N    . ALA A 1 60  ? -19.69983 -32.36706 2.87517   1.000 13.01182 ? 1519 ALA A N    1 
ATOM   848  C  CA   . ALA A 1 60  ? -19.66472 -31.99238 1.47468   1.000 13.05665 ? 1519 ALA A CA   1 
ATOM   849  C  C    . ALA A 1 60  ? -18.65696 -32.85719 0.71525   1.000 12.43024 ? 1519 ALA A C    1 
ATOM   850  O  O    . ALA A 1 60  ? -18.87669 -33.18155 -0.45434  1.000 13.11974 ? 1519 ALA A O    1 
ATOM   851  C  CB   . ALA A 1 60  ? -19.35684 -30.51108 1.33451   1.000 14.65143 ? 1519 ALA A CB   1 
ATOM   852  H  H    . ALA A 1 60  ? -19.46432 -31.74409 3.41927   1.000 15.61419 ? 1519 ALA A H    1 
ATOM   853  H  HA   . ALA A 1 60  ? -20.53742 -32.13555 1.07618   1.000 15.66798 ? 1519 ALA A HA   1 
ATOM   854  H  HB1  . ALA A 1 60  ? -19.34435 -30.27885 0.39280   1.000 17.58172 ? 1519 ALA A HB1  1 
ATOM   855  H  HB2  . ALA A 1 60  ? -20.04363 -30.00113 1.79187   1.000 17.58172 ? 1519 ALA A HB2  1 
ATOM   856  H  HB3  . ALA A 1 60  ? -18.49058 -30.32963 1.73146   1.000 17.58172 ? 1519 ALA A HB3  1 
ATOM   857  N  N    . GLN A 1 61  ? -17.49267 -33.13147 1.32640   1.000 12.67233 ? 1520 GLN A N    1 
ATOM   858  C  CA   . GLN A 1 61  ? -16.48391 -33.96750 0.66211   1.000 13.12767 ? 1520 GLN A CA   1 
ATOM   859  C  C    . GLN A 1 61  ? -17.05372 -35.34764 0.27479   1.000 12.21170 ? 1520 GLN A C    1 
ATOM   860  O  O    . GLN A 1 61  ? -16.84713 -35.82438 -0.84398  1.000 12.18020 ? 1520 GLN A O    1 
ATOM   861  C  CB   . GLN A 1 61  ? -15.26155 -34.15653 1.54855   1.000 15.08581 ? 1520 GLN A CB   1 
ATOM   862  C  CG   . GLN A 1 61  ? -14.35885 -32.96904 1.66531   1.000 17.01764 ? 1520 GLN A CG   1 
ATOM   863  C  CD   . GLN A 1 61  ? -13.33393 -33.07430 2.79412   1.000 20.32594 ? 1520 GLN A CD   1 
ATOM   864  O  OE1  . GLN A 1 61  ? -13.52861 -33.81406 3.77263   1.000 22.83395 ? 1520 GLN A OE1  1 
ATOM   865  N  NE2  . GLN A 1 61  ? -12.20967 -32.39244 2.63781   1.000 22.55233 ? 1520 GLN A NE2  1 
ATOM   866  H  H    . GLN A 1 61  ? -17.26832 -32.85157 2.10802   1.000 15.20680 ? 1520 GLN A H    1 
ATOM   867  H  HA   . GLN A 1 61  ? -16.20789 -33.50402 -0.14405  1.000 15.75320 ? 1520 GLN A HA   1 
ATOM   868  H  HB2  . GLN A 1 61  ? -15.56495 -34.37722 2.44306   1.000 18.10297 ? 1520 GLN A HB2  1 
ATOM   869  H  HB3  . GLN A 1 61  ? -14.73345 -34.88590 1.18796   1.000 18.10297 ? 1520 GLN A HB3  1 
ATOM   870  H  HG2  . GLN A 1 61  ? -13.87094 -32.86614 0.83329   1.000 20.42117 ? 1520 GLN A HG2  1 
ATOM   871  H  HG3  . GLN A 1 61  ? -14.90044 -32.18173 1.83186   1.000 20.42117 ? 1520 GLN A HG3  1 
ATOM   872  H  HE21 . GLN A 1 61  ? -12.08709 -31.92217 1.92829   1.000 27.06280 ? 1520 GLN A HE21 1 
ATOM   873  H  HE22 . GLN A 1 61  ? -11.60207 -32.41986 3.24581   1.000 27.06280 ? 1520 GLN A HE22 1 
ATOM   874  N  N    . LYS A 1 62  ? -17.78627 -35.96380 1.19347   1.000 12.71971 ? 1521 LYS A N    1 
ATOM   875  C  CA   . LYS A 1 62  ? -18.35013 -37.27905 0.89988   1.000 12.55135 ? 1521 LYS A CA   1 
ATOM   876  C  C    . LYS A 1 62  ? -19.44627 -37.17839 -0.14912  1.000 12.40128 ? 1521 LYS A C    1 
ATOM   877  O  O    . LYS A 1 62  ? -19.52038 -38.02922 -1.04312  1.000 13.10921 ? 1521 LYS A O    1 
ATOM   878  C  CB   . LYS A 1 62  ? -18.87388 -37.93845 2.17555   1.000 14.87790 ? 1521 LYS A CB   1 
ATOM   879  C  CG   . LYS A 1 62  ? -17.75917 -38.28951 3.13476   1.000 16.29910 ? 1521 LYS A CG   1 
ATOM   880  C  CD   . LYS A 1 62  ? -16.69091 -39.21698 2.44345   1.000 17.66233 ? 1521 LYS A CD   1 
ATOM   881  C  CE   . LYS A 1 62  ? -15.87271 -40.00021 3.40132   1.000 21.29437 ? 1521 LYS A CE   1 
ATOM   882  N  NZ   . LYS A 1 62  ? -14.91488 -40.85579 2.65790   1.000 22.54452 ? 1521 LYS A NZ   1 
ATOM   883  H  H    . LYS A 1 62  ? -17.96874 -35.65329 1.97442   1.000 15.26366 ? 1521 LYS A H    1 
ATOM   884  H  HA   . LYS A 1 62  ? -17.64682 -37.84818 0.55009   1.000 15.06162 ? 1521 LYS A HA   1 
ATOM   885  H  HB2  . LYS A 1 62  ? -19.47848 -37.32700 2.62442   1.000 17.85348 ? 1521 LYS A HB2  1 
ATOM   886  H  HB3  . LYS A 1 62  ? -19.34137 -38.75570 1.94220   1.000 17.85348 ? 1521 LYS A HB3  1 
ATOM   887  H  HG2  . LYS A 1 62  ? -17.31698 -37.47733 3.42755   1.000 19.55893 ? 1521 LYS A HG2  1 
ATOM   888  H  HG3  . LYS A 1 62  ? -18.12664 -38.76104 3.89865   1.000 19.55893 ? 1521 LYS A HG3  1 
ATOM   889  H  HD2  . LYS A 1 62  ? -17.14994 -39.84518 1.86417   1.000 21.19480 ? 1521 LYS A HD2  1 
ATOM   890  H  HD3  . LYS A 1 62  ? -16.08761 -38.66470 1.92200   1.000 21.19480 ? 1521 LYS A HD3  1 
ATOM   891  H  HE2  . LYS A 1 62  ? -15.37374 -39.39817 3.97533   1.000 25.55324 ? 1521 LYS A HE2  1 
ATOM   892  H  HE3  . LYS A 1 62  ? -16.44860 -40.56805 3.93687   1.000 25.55324 ? 1521 LYS A HE3  1 
ATOM   893  H  HZ1  . LYS A 1 62  ? -14.37953 -40.35014 2.15809   1.000 27.05343 ? 1521 LYS A HZ1  1 
ATOM   894  H  HZ2  . LYS A 1 62  ? -14.41890 -41.32475 3.22902   1.000 27.05343 ? 1521 LYS A HZ2  1 
ATOM   895  H  HZ3  . LYS A 1 62  ? -15.35678 -41.41900 2.12911   1.000 27.05343 ? 1521 LYS A HZ3  1 
ATOM   896  N  N    . LEU A 1 63  ? -20.30023 -36.13821 -0.07312  1.000 12.60653 ? 1522 LEU A N    1 
ATOM   897  C  CA   . LEU A 1 63  ? -21.32117 -35.95916 -1.10180  1.000 12.30130 ? 1522 LEU A CA   1 
ATOM   898  C  C    . LEU A 1 63  ? -20.68890 -35.75499 -2.47056  1.000 12.62758 ? 1522 LEU A C    1 
ATOM   899  O  O    . LEU A 1 63  ? -21.14480 -36.32393 -3.45614  1.000 12.93287 ? 1522 LEU A O    1 
ATOM   900  C  CB   . LEU A 1 63  ? -22.24683 -34.81631 -0.72033  1.000 12.64605 ? 1522 LEU A CB   1 
ATOM   901  C  CG   . LEU A 1 63  ? -23.07086 -35.05807 0.54214   1.000 15.05420 ? 1522 LEU A CG   1 
ATOM   902  C  CD1  . LEU A 1 63  ? -23.85154 -33.77540 0.91248   1.000 16.80431 ? 1522 LEU A CD1  1 
ATOM   903  C  CD2  . LEU A 1 63  ? -24.02431 -36.27175 0.39084   1.000 15.96740 ? 1522 LEU A CD2  1 
ATOM   904  H  H    . LEU A 1 63  ? -20.30310 -35.54391 0.54849   1.000 15.12784 ? 1522 LEU A H    1 
ATOM   905  H  HA   . LEU A 1 63  ? -21.86846 -36.75794 -1.15936  1.000 14.76156 ? 1522 LEU A HA   1 
ATOM   906  H  HB2  . LEU A 1 63  ? -21.71008 -34.02205 -0.57215  1.000 15.17525 ? 1522 LEU A HB2  1 
ATOM   907  H  HB3  . LEU A 1 63  ? -22.86718 -34.66600 -1.45072  1.000 15.17525 ? 1522 LEU A HB3  1 
ATOM   908  H  HG   . LEU A 1 63  ? -22.46772 -35.27510 1.27016   1.000 18.06504 ? 1522 LEU A HG   1 
ATOM   909  H  HD11 . LEU A 1 63  ? -24.36729 -33.94087 1.71717   1.000 20.16517 ? 1522 LEU A HD11 1 
ATOM   910  H  HD12 . LEU A 1 63  ? -23.22050 -33.05497 1.06634   1.000 20.16517 ? 1522 LEU A HD12 1 
ATOM   911  H  HD13 . LEU A 1 63  ? -24.44507 -33.54462 0.18079   1.000 20.16517 ? 1522 LEU A HD13 1 
ATOM   912  H  HD21 . LEU A 1 63  ? -24.55332 -36.36044 1.19904   1.000 19.16088 ? 1522 LEU A HD21 1 
ATOM   913  H  HD22 . LEU A 1 63  ? -24.60631 -36.12312 -0.37079  1.000 19.16088 ? 1522 LEU A HD22 1 
ATOM   914  H  HD23 . LEU A 1 63  ? -23.49579 -37.07315 0.25186   1.000 19.16088 ? 1522 LEU A HD23 1 
ATOM   915  N  N    . ALA A 1 64  ? -19.62186 -34.94511 -2.52629  1.000 11.69857 ? 1523 ALA A N    1 
ATOM   916  C  CA   . ALA A 1 64  ? -18.95756 -34.70232 -3.79712  1.000 12.11433 ? 1523 ALA A CA   1 
ATOM   917  C  C    . ALA A 1 64  ? -18.25940 -35.97452 -4.30007  1.000 11.61174 ? 1523 ALA A C    1 
ATOM   918  O  O    . ALA A 1 64  ? -18.31100 -36.28618 -5.50042  1.000 12.36699 ? 1523 ALA A O    1 
ATOM   919  C  CB   . ALA A 1 64  ? -17.95032 -33.55669 -3.59678  1.000 11.63009 ? 1523 ALA A CB   1 
ATOM   920  H  H    . ALA A 1 64  ? -19.27565 -34.53626 -1.85355  1.000 14.03828 ? 1523 ALA A H    1 
ATOM   921  H  HA   . ALA A 1 64  ? -19.60028 -34.44017 -4.47468  1.000 14.53720 ? 1523 ALA A HA   1 
ATOM   922  H  HB1  . ALA A 1 64  ? -17.54256 -33.34182 -4.45028  1.000 13.95611 ? 1523 ALA A HB1  1 
ATOM   923  H  HB2  . ALA A 1 64  ? -18.41870 -32.78151 -3.24948  1.000 13.95611 ? 1523 ALA A HB2  1 
ATOM   924  H  HB3  . ALA A 1 64  ? -17.26947 -33.84127 -2.96722  1.000 13.95611 ? 1523 ALA A HB3  1 
ATOM   925  N  N    . GLU A 1 65  ? -17.56036 -36.67879 -3.43718  1.000 12.23017 ? 1524 GLU A N    1 
ATOM   926  C  CA   . GLU A 1 65  ? -16.86256 -37.90955 -3.89351  1.000 14.07510 ? 1524 GLU A CA   1 
ATOM   927  C  C    . GLU A 1 65  ? -17.83191 -38.94225 -4.43198  1.000 14.71468 ? 1524 GLU A C    1 
ATOM   928  O  O    . GLU A 1 65  ? -17.47942 -39.72888 -5.31866  1.000 15.98054 ? 1524 GLU A O    1 
ATOM   929  C  CB   . GLU A 1 65  ? -16.02499 -38.48972 -2.74127  1.000 13.16718 ? 1524 GLU A CB   1 
ATOM   930  C  CG   . GLU A 1 65  ? -14.80675 -37.60724 -2.45427  1.000 13.66728 ? 1524 GLU A CG   1 
ATOM   931  C  CD   . GLU A 1 65  ? -13.88496 -38.14567 -1.44714  1.000 15.77538 ? 1524 GLU A CD   1 
ATOM   932  O  OE1  . GLU A 1 65  ? -14.30175 -38.94535 -0.61262  1.000 19.09655 ? 1524 GLU A OE1  1 
ATOM   933  O  OE2  . GLU A 1 65  ? -12.69151 -37.72671 -1.44918  1.000 15.75694 ? 1524 GLU A OE2  1 
ATOM   934  H  H    . GLU A 1 65  ? -17.46353 -36.49037 -2.60368  1.000 14.67621 ? 1524 GLU A H    1 
ATOM   935  H  HA   . GLU A 1 65  ? -16.25748 -37.67953 -4.61592  1.000 16.89012 ? 1524 GLU A HA   1 
ATOM   936  H  HB2  . GLU A 1 65  ? -16.56802 -38.53610 -1.93886  1.000 15.80062 ? 1524 GLU A HB2  1 
ATOM   937  H  HB3  . GLU A 1 65  ? -15.71362 -39.37605 -2.98284  1.000 15.80062 ? 1524 GLU A HB3  1 
ATOM   938  H  HG2  . GLU A 1 65  ? -14.30624 -37.49450 -3.27749  1.000 16.40074 ? 1524 GLU A HG2  1 
ATOM   939  H  HG3  . GLU A 1 65  ? -15.11778 -36.74590 -2.13450  1.000 16.40074 ? 1524 GLU A HG3  1 
ATOM   940  N  N    . ALA A 1 66  ? -19.06991 -38.93948 -3.93212  1.000 14.14624 ? 1525 ALA A N    1 
ATOM   941  C  CA   . ALA A 1 66  ? -20.08134 -39.91214 -4.35311  1.000 13.94884 ? 1525 ALA A CA   1 
ATOM   942  C  C    . ALA A 1 66  ? -20.83480 -39.45303 -5.58273  1.000 14.32510 ? 1525 ALA A C    1 
ATOM   943  O  O    . ALA A 1 66  ? -21.34167 -40.30516 -6.34119  1.000 14.07248 ? 1525 ALA A O    1 
ATOM   944  C  CB   . ALA A 1 66  ? -21.08661 -40.13455 -3.21609  1.000 14.31723 ? 1525 ALA A CB   1 
ATOM   945  H  H    . ALA A 1 66  ? -19.35162 -38.37995 -3.34292  1.000 16.97548 ? 1525 ALA A H    1 
ATOM   946  H  HA   . ALA A 1 66  ? -19.64833 -40.75697 -4.55226  1.000 16.73861 ? 1525 ALA A HA   1 
ATOM   947  H  HB1  . ALA A 1 66  ? -21.75408 -40.77605 -3.50567  1.000 17.18068 ? 1525 ALA A HB1  1 
ATOM   948  H  HB2  . ALA A 1 66  ? -20.61514 -40.47533 -2.43988  1.000 17.18068 ? 1525 ALA A HB2  1 
ATOM   949  H  HB3  . ALA A 1 66  ? -21.51149 -39.28964 -3.00044  1.000 17.18068 ? 1525 ALA A HB3  1 
ATOM   950  N  N    . GLY A 1 67  ? -20.96389 -38.13632 -5.78086  1.000 13.41457 ? 1526 GLY A N    1 
ATOM   951  C  CA   . GLY A 1 67  ? -21.80490 -37.62735 -6.84751  1.000 12.56702 ? 1526 GLY A CA   1 
ATOM   952  C  C    . GLY A 1 67  ? -21.08994 -37.02869 -8.03718  1.000 11.82224 ? 1526 GLY A C    1 
ATOM   953  O  O    . GLY A 1 67  ? -21.61657 -36.97962 -9.15264  1.000 12.53018 ? 1526 GLY A O    1 
ATOM   954  H  H    . GLY A 1 67  ? -20.57520 -37.52970 -5.31126  1.000 16.09749 ? 1526 GLY A H    1 
ATOM   955  H  HA2  . GLY A 1 67  ? -22.35423 -38.35568 -7.17717  1.000 15.08043 ? 1526 GLY A HA2  1 
ATOM   956  H  HA3  . GLY A 1 67  ? -22.38080 -36.93870 -6.48009  1.000 15.08043 ? 1526 GLY A HA3  1 
ATOM   957  N  N    . ALA A 1 68  ? -19.89415 -36.45989 -7.80524  1.000 11.65383 ? 1527 ALA A N    1 
ATOM   958  C  CA   . ALA A 1 68  ? -19.24075 -35.73750 -8.87309  1.000 12.33012 ? 1527 ALA A CA   1 
ATOM   959  C  C    . ALA A 1 68  ? -18.78812 -36.68667 -9.97528  1.000 12.28542 ? 1527 ALA A C    1 
ATOM   960  O  O    . ALA A 1 68  ? -18.25878 -37.79365 -9.70372  1.000 13.14080 ? 1527 ALA A O    1 
ATOM   961  C  CB   . ALA A 1 68  ? -18.01684 -35.01172 -8.34213  1.000 11.59852 ? 1527 ALA A CB   1 
ATOM   962  H  H    . ALA A 1 68  ? -19.46650 -36.48483 -7.05953  1.000 13.98459 ? 1527 ALA A H    1 
ATOM   963  H  HA   . ALA A 1 68  ? -19.86864 -35.09598 -9.24065  1.000 14.79615 ? 1527 ALA A HA   1 
ATOM   964  H  HB1  . ALA A 1 68  ? -17.59334 -34.53183 -9.07100  1.000 13.91822 ? 1527 ALA A HB1  1 
ATOM   965  H  HB2  . ALA A 1 68  ? -18.29379 -34.38841 -7.65244  1.000 13.91822 ? 1527 ALA A HB2  1 
ATOM   966  H  HB3  . ALA A 1 68  ? -17.39992 -35.66220 -7.97174  1.000 13.91822 ? 1527 ALA A HB3  1 
ATOM   967  N  N    . ARG A 1 69  ? -18.91390 -36.21640 -11.21615 1.000 11.66435 ? 1528 ARG A N    1 
ATOM   968  C  CA   . ARG A 1 69  ? -18.48159 -36.93058 -12.41681 1.000 12.21699 ? 1528 ARG A CA   1 
ATOM   969  C  C    . ARG A 1 69  ? -17.18823 -36.36375 -12.96909 1.000 11.86168 ? 1528 ARG A C    1 
ATOM   970  O  O    . ARG A 1 69  ? -16.52584 -37.01444 -13.79724 1.000 12.61175 ? 1528 ARG A O    1 
ATOM   971  C  CB   . ARG A 1 69  ? -19.52687 -36.83771 -13.51677 1.000 13.13554 ? 1528 ARG A CB   1 
ATOM   972  C  CG   . ARG A 1 69  ? -20.92034 -37.32523 -13.10268 1.000 13.77778 ? 1528 ARG A CG   1 
ATOM   973  C  CD   . ARG A 1 69  ? -21.89154 -36.99220 -14.19471 1.000 14.34880 ? 1528 ARG A CD   1 
ATOM   974  N  NE   . ARG A 1 69  ? -23.28626 -37.28478 -13.83870 1.000 14.37783 ? 1528 ARG A NE   1 
ATOM   975  C  CZ   . ARG A 1 69  ? -23.90604 -38.41900 -14.14899 1.000 15.10164 ? 1528 ARG A CZ   1 
ATOM   976  N  NH1  . ARG A 1 69  ? -23.25648 -39.41758 -14.71189 1.000 16.87803 ? 1528 ARG A NH1  1 
ATOM   977  N  NH2  . ARG A 1 69  ? -25.19835 -38.55099 -13.86808 1.000 15.93843 ? 1528 ARG A NH2  1 
ATOM   978  H  H    . ARG A 1 69  ? -19.26227 -35.45127 -11.39731 1.000 13.99722 ? 1528 ARG A H    1 
ATOM   979  H  HA   . ARG A 1 69  ? -18.36915 -37.86823 -12.19529 1.000 14.66039 ? 1528 ARG A HA   1 
ATOM   980  H  HB2  . ARG A 1 69  ? -19.60857 -35.91039 -13.78935 1.000 15.76265 ? 1528 ARG A HB2  1 
ATOM   981  H  HB3  . ARG A 1 69  ? -19.23647 -37.37968 -14.26700 1.000 15.76265 ? 1528 ARG A HB3  1 
ATOM   982  H  HG2  . ARG A 1 69  ? -20.90994 -38.28616 -12.97078 1.000 16.53333 ? 1528 ARG A HG2  1 
ATOM   983  H  HG3  . ARG A 1 69  ? -21.19800 -36.88127 -12.28616 1.000 16.53333 ? 1528 ARG A HG3  1 
ATOM   984  H  HD2  . ARG A 1 69  ? -21.82761 -36.04513 -14.39438 1.000 17.21855 ? 1528 ARG A HD2  1 
ATOM   985  H  HD3  . ARG A 1 69  ? -21.66977 -37.51303 -14.98240 1.000 17.21855 ? 1528 ARG A HD3  1 
ATOM   986  H  HE   . ARG A 1 69  ? -23.72735 -36.68775 -13.40442 1.000 17.25339 ? 1528 ARG A HE   1 
ATOM   987  H  HH11 . ARG A 1 69  ? -22.41740 -39.34181 -14.88453 1.000 20.25364 ? 1528 ARG A HH11 1 
ATOM   988  H  HH12 . ARG A 1 69  ? -23.67157 -40.14514 -14.90668 1.000 20.25364 ? 1528 ARG A HH12 1 
ATOM   989  H  HH21 . ARG A 1 69  ? -25.62413 -37.90667 -13.48972 1.000 19.12612 ? 1528 ARG A HH21 1 
ATOM   990  H  HH22 . ARG A 1 69  ? -25.60878 -39.28071 -14.06467 1.000 19.12612 ? 1528 ARG A HH22 1 
ATOM   991  N  N    . CYS A 1 70  ? -16.88412 -35.10145 -12.63718 1.000 11.10910 ? 1529 CYS A N    1 
ATOM   992  C  CA   . CYS A 1 70  ? -15.56888 -34.52395 -12.93576 1.000 11.73270 ? 1529 CYS A CA   1 
ATOM   993  C  C    . CYS A 1 70  ? -14.84411 -34.21043 -11.64404 1.000 11.28006 ? 1529 CYS A C    1 
ATOM   994  O  O    . CYS A 1 70  ? -15.40195 -34.35690 -10.57787 1.000 11.31425 ? 1529 CYS A O    1 
ATOM   995  C  CB   . CYS A 1 70  ? -15.67740 -33.29901 -13.82528 1.000 12.52748 ? 1529 CYS A CB   1 
ATOM   996  S  SG   . CYS A 1 70  ? -16.39098 -31.81262 -13.05792 1.000 12.41434 ? 1529 CYS A SG   1 
ATOM   997  H  H    . CYS A 1 70  ? -17.42365 -34.56281 -12.23922 1.000 13.33092 ? 1529 CYS A H    1 
ATOM   998  H  HA   . CYS A 1 70  ? -15.03798 -35.17461 -13.42123 1.000 14.07924 ? 1529 CYS A HA   1 
ATOM   999  H  HB2  . CYS A 1 70  ? -14.78598 -33.06491 -14.12771 1.000 15.03297 ? 1529 CYS A HB2  1 
ATOM   1000 H  HB3  . CYS A 1 70  ? -16.23665 -33.52536 -14.58482 1.000 15.03297 ? 1529 CYS A HB3  1 
ATOM   1001 H  HG   . CYS A 1 70  ? -15.71590 -31.49589 -12.11774 1.000 14.89721 ? 1529 CYS A HG   1 
ATOM   1002 N  N    . ASP A 1 71  ? -13.56473 -33.81374 -11.74922 1.000 10.52732 ? 1530 ASP A N    1 
ATOM   1003 C  CA   . ASP A 1 71  ? -12.80984 -33.56044 -10.53343 1.000 10.34580 ? 1530 ASP A CA   1 
ATOM   1004 C  C    . ASP A 1 71  ? -13.17139 -32.18381 -9.95702  1.000 10.21937 ? 1530 ASP A C    1 
ATOM   1005 O  O    . ASP A 1 71  ? -13.78092 -31.31863 -10.63697 1.000 10.32994 ? 1530 ASP A O    1 
ATOM   1006 C  CB   . ASP A 1 71  ? -11.31806 -33.71958 -10.80607 1.000 11.43795 ? 1530 ASP A CB   1 
ATOM   1007 C  CG   . ASP A 1 71  ? -10.95394 -35.12188 -11.30115 1.000 11.15636 ? 1530 ASP A CG   1 
ATOM   1008 O  OD1  . ASP A 1 71  ? -11.63052 -36.05814 -10.82464 1.000 12.15908 ? 1530 ASP A OD1  1 
ATOM   1009 O  OD2  . ASP A 1 71  ? -10.06146 -35.24517 -12.14577 1.000 10.97213 ? 1530 ASP A OD2  1 
ATOM   1010 H  H    . ASP A 1 71  ? -13.13821 -33.69205 -12.48602 1.000 12.63279 ? 1530 ASP A H    1 
ATOM   1011 H  HA   . ASP A 1 71  ? -13.03245 -34.20572 -9.84426  1.000 12.41496 ? 1530 ASP A HA   1 
ATOM   1012 H  HB2  . ASP A 1 71  ? -11.05122 -33.08225 -11.48688 1.000 13.72553 ? 1530 ASP A HB2  1 
ATOM   1013 H  HB3  . ASP A 1 71  ? -10.82723 -33.55397 -9.98598  1.000 13.72553 ? 1530 ASP A HB3  1 
ATOM   1014 N  N    . PHE A 1 72  ? -12.83628 -32.01222 -8.68779  1.000 9.89042  ? 1531 PHE A N    1 
ATOM   1015 C  CA   . PHE A 1 72  ? -13.31094 -30.82655 -7.98733  1.000 10.02468 ? 1531 PHE A CA   1 
ATOM   1016 C  C    . PHE A 1 72  ? -12.39992 -30.44100 -6.82890  1.000 11.10626 ? 1531 PHE A C    1 
ATOM   1017 O  O    . PHE A 1 72  ? -11.58514 -31.22802 -6.32476  1.000 10.88267 ? 1531 PHE A O    1 
ATOM   1018 C  CB   . PHE A 1 72  ? -14.75531 -31.07532 -7.48144  1.000 10.55097 ? 1531 PHE A CB   1 
ATOM   1019 C  CG   . PHE A 1 72  ? -14.80442 -32.17670 -6.47727  1.000 10.04315 ? 1531 PHE A CG   1 
ATOM   1020 C  CD1  . PHE A 1 72  ? -14.58490 -31.96769 -5.13014  1.000 10.37738 ? 1531 PHE A CD1  1 
ATOM   1021 C  CD2  . PHE A 1 72  ? -15.02579 -33.50998 -6.88493  1.000 10.64574 ? 1531 PHE A CD2  1 
ATOM   1022 C  CE1  . PHE A 1 72  ? -14.54279 -32.99474 -4.20989  1.000 11.96953 ? 1531 PHE A CE1  1 
ATOM   1023 C  CE2  . PHE A 1 72  ? -15.01662 -34.52814 -5.94072  1.000 10.59576 ? 1531 PHE A CE2  1 
ATOM   1024 C  CZ   . PHE A 1 72  ? -14.77694 -34.29433 -4.62808  1.000 11.31951 ? 1531 PHE A CZ   1 
ATOM   1025 H  H    . PHE A 1 72  ? -12.35096 -32.54955 -8.22374  1.000 11.86851 ? 1531 PHE A H    1 
ATOM   1026 H  HA   . PHE A 1 72  ? -13.28177 -30.07177 -8.59591  1.000 12.02961 ? 1531 PHE A HA   1 
ATOM   1027 H  HB2  . PHE A 1 72  ? -15.09191 -30.26693 -7.06417  1.000 12.66116 ? 1531 PHE A HB2  1 
ATOM   1028 H  HB3  . PHE A 1 72  ? -15.31921 -31.32106 -8.23146  1.000 12.66116 ? 1531 PHE A HB3  1 
ATOM   1029 H  HD1  . PHE A 1 72  ? -14.45995 -31.09638 -4.82997  1.000 12.45286 ? 1531 PHE A HD1  1 
ATOM   1030 H  HD2  . PHE A 1 72  ? -15.17703 -33.70549 -7.78148  1.000 12.77489 ? 1531 PHE A HD2  1 
ATOM   1031 H  HE1  . PHE A 1 72  ? -14.35868 -32.81594 -3.31600  1.000 14.36343 ? 1531 PHE A HE1  1 
ATOM   1032 H  HE2  . PHE A 1 72  ? -15.18061 -35.40025 -6.21898  1.000 12.71491 ? 1531 PHE A HE2  1 
ATOM   1033 H  HZ   . PHE A 1 72  ? -14.76972 -34.99550 -4.01718  1.000 13.58342 ? 1531 PHE A HZ   1 
ATOM   1034 N  N    . ALA A 1 73  ? -12.58051 -29.20538 -6.37881  1.000 10.21946 ? 1532 ALA A N    1 
ATOM   1035 C  CA   . ALA A 1 73  ? -12.12991 -28.75927 -5.09310  1.000 11.14317 ? 1532 ALA A CA   1 
ATOM   1036 C  C    . ALA A 1 73  ? -13.29434 -27.98813 -4.46326  1.000 10.43523 ? 1532 ALA A C    1 
ATOM   1037 O  O    . ALA A 1 73  ? -14.09710 -27.38757 -5.18047  1.000 9.79567  ? 1532 ALA A O    1 
ATOM   1038 C  CB   . ALA A 1 73  ? -10.84728 -27.89073 -5.19541  1.000 11.67478 ? 1532 ALA A CB   1 
ATOM   1039 H  H    . ALA A 1 73  ? -12.97959 -28.58997 -6.82783  1.000 12.26335 ? 1532 ALA A H    1 
ATOM   1040 H  HA   . ALA A 1 73  ? -11.89336 -29.50168 -4.51537  1.000 13.37180 ? 1532 ALA A HA   1 
ATOM   1041 H  HB1  . ALA A 1 73  ? -10.58357 -27.61081 -4.30490  1.000 14.00973 ? 1532 ALA A HB1  1 
ATOM   1042 H  HB2  . ALA A 1 73  ? -10.14031 -28.41790 -5.59937  1.000 14.00973 ? 1532 ALA A HB2  1 
ATOM   1043 H  HB3  . ALA A 1 73  ? -11.03520 -27.11343 -5.74440  1.000 14.00973 ? 1532 ALA A HB3  1 
ATOM   1044 N  N    . LEU A 1 74  ? -13.36693 -27.98131 -3.13365  1.000 9.64043  ? 1533 LEU A N    1 
ATOM   1045 C  CA   . LEU A 1 74  ? -14.47380 -27.33595 -2.41989  1.000 9.56932  ? 1533 LEU A CA   1 
ATOM   1046 C  C    . LEU A 1 74  ? -13.94325 -26.10877 -1.69186  1.000 9.57722  ? 1533 LEU A C    1 
ATOM   1047 O  O    . LEU A 1 74  ? -13.02509 -26.22287 -0.88811  1.000 10.72471 ? 1533 LEU A O    1 
ATOM   1048 C  CB   . LEU A 1 74  ? -15.06874 -28.31060 -1.40016  1.000 10.53263 ? 1533 LEU A CB   1 
ATOM   1049 C  CG   . LEU A 1 74  ? -15.52978 -29.63454 -1.98578  1.000 12.30923 ? 1533 LEU A CG   1 
ATOM   1050 C  CD1  . LEU A 1 74  ? -16.17270 -30.50439 -0.89327  1.000 16.39101 ? 1533 LEU A CD1  1 
ATOM   1051 C  CD2  . LEU A 1 74  ? -16.55245 -29.47456 -3.12634  1.000 12.19332 ? 1533 LEU A CD2  1 
ATOM   1052 H  H    . LEU A 1 74  ? -12.78367 -28.34607 -2.61754  1.000 11.56852 ? 1533 LEU A H    1 
ATOM   1053 H  HA   . LEU A 1 74  ? -15.16136 -27.05828 -3.04524  1.000 11.48318 ? 1533 LEU A HA   1 
ATOM   1054 H  HB2  . LEU A 1 74  ? -14.39460 -28.50506 -0.73037  1.000 12.63916 ? 1533 LEU A HB2  1 
ATOM   1055 H  HB3  . LEU A 1 74  ? -15.83772 -27.89009 -0.98455  1.000 12.63916 ? 1533 LEU A HB3  1 
ATOM   1056 H  HG   . LEU A 1 74  ? -14.73929 -30.06091 -2.35217  1.000 14.77108 ? 1533 LEU A HG   1 
ATOM   1057 H  HD11 . LEU A 1 74  ? -16.45032 -31.34779 -1.28376  1.000 19.66922 ? 1533 LEU A HD11 1 
ATOM   1058 H  HD12 . LEU A 1 74  ? -15.52159 -30.66298 -0.19198  1.000 19.66922 ? 1533 LEU A HD12 1 
ATOM   1059 H  HD13 . LEU A 1 74  ? -16.94237 -30.03842 -0.53081  1.000 19.66922 ? 1533 LEU A HD13 1 
ATOM   1060 H  HD21 . LEU A 1 74  ? -16.84105 -30.35372 -3.41735  1.000 14.63198 ? 1533 LEU A HD21 1 
ATOM   1061 H  HD22 . LEU A 1 74  ? -17.31266 -28.96804 -2.80012  1.000 14.63198 ? 1533 LEU A HD22 1 
ATOM   1062 H  HD23 . LEU A 1 74  ? -16.13269 -29.00352 -3.86311  1.000 14.63198 ? 1533 LEU A HD23 1 
ATOM   1063 N  N    . PHE A 1 75  ? -14.59073 -24.95346 -1.88208  1.000 9.28776  ? 1534 PHE A N    1 
ATOM   1064 C  CA   . PHE A 1 75  ? -14.29590 -23.77999 -1.08165  1.000 9.89561  ? 1534 PHE A CA   1 
ATOM   1065 C  C    . PHE A 1 75  ? -14.84157 -23.92848 0.34407   1.000 9.86942  ? 1534 PHE A C    1 
ATOM   1066 O  O    . PHE A 1 75  ? -15.89223 -24.54467 0.59458   1.000 10.79836 ? 1534 PHE A O    1 
ATOM   1067 C  CB   . PHE A 1 75  ? -14.90192 -22.51605 -1.73655  1.000 7.88229  ? 1534 PHE A CB   1 
ATOM   1068 C  CG   . PHE A 1 75  ? -14.17235 -21.98055 -2.86707  1.000 7.71658  ? 1534 PHE A CG   1 
ATOM   1069 C  CD1  . PHE A 1 75  ? -13.02439 -21.15086 -2.64876  1.000 9.77988  ? 1534 PHE A CD1  1 
ATOM   1070 C  CD2  . PHE A 1 75  ? -14.53033 -22.19500 -4.17838  1.000 8.54553  ? 1534 PHE A CD2  1 
ATOM   1071 C  CE1  . PHE A 1 75  ? -12.36397 -20.65226 -3.74012  1.000 11.46155 ? 1534 PHE A CE1  1 
ATOM   1072 C  CE2  . PHE A 1 75  ? -13.90710 -21.67196 -5.24125  1.000 9.72986  ? 1534 PHE A CE2  1 
ATOM   1073 C  CZ   . PHE A 1 75  ? -12.75511 -20.89179 -5.04161  1.000 10.80896 ? 1534 PHE A CZ   1 
ATOM   1074 H  H    . PHE A 1 75  ? -15.20497 -24.83088 -2.47139  1.000 11.14531 ? 1534 PHE A H    1 
ATOM   1075 H  HA   . PHE A 1 75  ? -13.33357 -23.67126 -1.02677  1.000 11.87473 ? 1534 PHE A HA   1 
ATOM   1076 H  HB2  . PHE A 1 75  ? -15.79468 -22.73320 -2.04754  1.000 9.45875  ? 1534 PHE A HB2  1 
ATOM   1077 H  HB3  . PHE A 1 75  ? -14.94526 -21.81705 -1.06542  1.000 9.45875  ? 1534 PHE A HB3  1 
ATOM   1078 H  HD1  . PHE A 1 75  ? -12.73485 -20.95573 -1.78679  1.000 11.73586 ? 1534 PHE A HD1  1 
ATOM   1079 H  HD2  . PHE A 1 75  ? -15.26210 -22.74614 -4.33856  1.000 10.25463 ? 1534 PHE A HD2  1 
ATOM   1080 H  HE1  . PHE A 1 75  ? -11.61201 -20.12423 -3.59643  1.000 13.75386 ? 1534 PHE A HE1  1 
ATOM   1081 H  HE2  . PHE A 1 75  ? -14.23171 -21.82262 -6.09964  1.000 11.67583 ? 1534 PHE A HE2  1 
ATOM   1082 H  HZ   . PHE A 1 75  ? -12.27415 -20.54958 -5.76026  1.000 12.97075 ? 1534 PHE A HZ   1 
ATOM   1083 N  N    . LEU A 1 76  ? -14.14916 -23.30607 1.28453   1.000 10.45890 ? 1535 LEU A N    1 
ATOM   1084 C  CA   . LEU A 1 76  ? -14.69759 -22.94350 2.57704   1.000 10.38520 ? 1535 LEU A CA   1 
ATOM   1085 C  C    . LEU A 1 76  ? -15.24824 -21.54061 2.47118   1.000 10.39310 ? 1535 LEU A C    1 
ATOM   1086 O  O    . LEU A 1 76  ? -14.76822 -20.73064 1.67128   1.000 10.50890 ? 1535 LEU A O    1 
ATOM   1087 C  CB   . LEU A 1 76  ? -13.65365 -22.99343 3.69964   1.000 10.64843 ? 1535 LEU A CB   1 
ATOM   1088 C  CG   . LEU A 1 76  ? -13.38030 -24.43559 4.19830   1.000 12.08287 ? 1535 LEU A CG   1 
ATOM   1089 C  CD1  . LEU A 1 76  ? -11.98222 -24.53321 4.82869   1.000 12.26959 ? 1535 LEU A CD1  1 
ATOM   1090 C  CD2  . LEU A 1 76  ? -14.45484 -24.82037 5.19156   1.000 14.03558 ? 1535 LEU A CD2  1 
ATOM   1091 H  H    . LEU A 1 76  ? -13.32611 -23.07398 1.19328   1.000 12.55068 ? 1535 LEU A H    1 
ATOM   1092 H  HA   . LEU A 1 76  ? -15.39168 -23.57509 2.82246   1.000 12.46225 ? 1535 LEU A HA   1 
ATOM   1093 H  HB2  . LEU A 1 76  ? -12.81883 -22.62513 3.37050   1.000 12.77812 ? 1535 LEU A HB2  1 
ATOM   1094 H  HB3  . LEU A 1 76  ? -13.97359 -22.47031 4.45123   1.000 12.77812 ? 1535 LEU A HB3  1 
ATOM   1095 H  HG   . LEU A 1 76  ? -13.40180 -25.05867 3.45520   1.000 14.49944 ? 1535 LEU A HG   1 
ATOM   1096 H  HD11 . LEU A 1 76  ? -11.83487 -25.44309 5.13084   1.000 14.72351 ? 1535 LEU A HD11 1 
ATOM   1097 H  HD12 . LEU A 1 76  ? -11.31832 -24.29407 4.16315   1.000 14.72351 ? 1535 LEU A HD12 1 
ATOM   1098 H  HD13 . LEU A 1 76  ? -11.93155 -23.92264 5.58071   1.000 14.72351 ? 1535 LEU A HD13 1 
ATOM   1099 H  HD21 . LEU A 1 76  ? -14.32637 -25.74553 5.45321   1.000 16.84270 ? 1535 LEU A HD21 1 
ATOM   1100 H  HD22 . LEU A 1 76  ? -14.38715 -24.24428 5.96902   1.000 16.84270 ? 1535 LEU A HD22 1 
ATOM   1101 H  HD23 . LEU A 1 76  ? -15.32385 -24.71222 4.77439   1.000 16.84270 ? 1535 LEU A HD23 1 
ATOM   1102 N  N    . GLY A 1 77  ? -16.25097 -21.23687 3.28818   1.000 10.61158 ? 1536 GLY A N    1 
ATOM   1103 C  CA   . GLY A 1 77  ? -16.80095 -19.88343 3.38137   1.000 10.39834 ? 1536 GLY A CA   1 
ATOM   1104 C  C    . GLY A 1 77  ? -16.43101 -19.21080 4.68920   1.000 10.12465 ? 1536 GLY A C    1 
ATOM   1105 O  O    . GLY A 1 77  ? -16.48967 -19.80864 5.75213   1.000 10.82996 ? 1536 GLY A O    1 
ATOM   1106 H  H    . GLY A 1 77  ? -16.63659 -21.80414 3.80694   1.000 12.73389 ? 1536 GLY A H    1 
ATOM   1107 H  HA2  . GLY A 1 77  ? -16.45876 -19.34433 2.65118   1.000 12.47801 ? 1536 GLY A HA2  1 
ATOM   1108 H  HA3  . GLY A 1 77  ? -17.76815 -19.92238 3.31886   1.000 12.47801 ? 1536 GLY A HA3  1 
ATOM   1109 N  N    . ALA A 1 78  ? -16.14269 -17.90902 4.59972   1.000 10.40371 ? 1537 ALA A N    1 
ATOM   1110 C  CA   . ALA A 1 78  ? -15.93646 -17.07117 5.75997   1.000 11.01688 ? 1537 ALA A CA   1 
ATOM   1111 C  C    . ALA A 1 78  ? -17.26516 -16.73598 6.40099   1.000 11.90909 ? 1537 ALA A C    1 
ATOM   1112 O  O    . ALA A 1 78  ? -18.23047 -16.40686 5.71015   1.000 12.74068 ? 1537 ALA A O    1 
ATOM   1113 C  CB   . ALA A 1 78  ? -15.24353 -15.77909 5.34599   1.000 11.55114 ? 1537 ALA A CB   1 
ATOM   1114 H  H    . ALA A 1 78  ? -16.06108 -17.48582 3.85551   1.000 12.48446 ? 1537 ALA A H    1 
ATOM   1115 H  HA   . ALA A 1 78  ? -15.38258 -17.53621 6.40639   1.000 13.22026 ? 1537 ALA A HA   1 
ATOM   1116 H  HB1  . ALA A 1 78  ? -15.14970 -15.20771 6.12421   1.000 13.86136 ? 1537 ALA A HB1  1 
ATOM   1117 H  HB2  . ALA A 1 78  ? -14.36894 -15.99164 4.98431   1.000 13.86136 ? 1537 ALA A HB2  1 
ATOM   1118 H  HB3  . ALA A 1 78  ? -15.78104 -15.33441 4.67202   1.000 13.86136 ? 1537 ALA A HB3  1 
ATOM   1119 N  N    . ALA A 1 79  ? -17.32193 -16.78071 7.70810   1.000 11.41178 ? 1538 ALA A N    1 
ATOM   1120 C  CA   . ALA A 1 79  ? -18.49714 -16.38351 8.45482   1.000 13.14349 ? 1538 ALA A CA   1 
ATOM   1121 C  C    . ALA A 1 79  ? -18.11923 -15.38924 9.54119   1.000 13.78571 ? 1538 ALA A C    1 
ATOM   1122 O  O    . ALA A 1 79  ? -16.94138 -15.14087 9.79789   1.000 14.09358 ? 1538 ALA A O    1 
ATOM   1123 C  CB   . ALA A 1 79  ? -19.12792 -17.61256 9.18675   1.000 17.33064 ? 1538 ALA A CB   1 
ATOM   1124 H  H    . ALA A 1 79  ? -16.67281 -17.04587 8.20603   1.000 13.69413 ? 1538 ALA A H    1 
ATOM   1125 H  HA   . ALA A 1 79  ? -19.12123 -15.97833 7.83254   1.000 15.77218 ? 1538 ALA A HA   1 
ATOM   1126 H  HB1  . ALA A 1 79  ? -19.34413 -18.29383 8.53099   1.000 20.79676 ? 1538 ALA A HB1  1 
ATOM   1127 H  HB2  . ALA A 1 79  ? -19.93361 -17.32752 9.64557   1.000 20.79676 ? 1538 ALA A HB2  1 
ATOM   1128 H  HB3  . ALA A 1 79  ? -18.48826 -17.96112 9.82725   1.000 20.79676 ? 1538 ALA A HB3  1 
ATOM   1129 N  N    . SER A 1 80  ? -19.12848 -14.87731 10.22657  1.000 17.11494 ? 1539 SER A N    1 
ATOM   1130 C  CA   . SER A 1 80  ? -18.92528 -13.97395 11.34365  1.000 19.15214 ? 1539 SER A CA   1 
ATOM   1131 C  C    . SER A 1 80  ? -18.40413 -14.66824 12.58597  1.000 20.65228 ? 1539 SER A C    1 
ATOM   1132 O  O    . SER A 1 80  ? -18.09068 -13.98070 13.56950  1.000 23.44193 ? 1539 SER A O    1 
ATOM   1133 C  CB   . SER A 1 80  ? -20.23860 -13.23966 11.68086  1.000 22.88931 ? 1539 SER A CB   1 
ATOM   1134 O  OG   . SER A 1 80  ? -21.18876 -14.16229 12.17268  1.000 25.30795 ? 1539 SER A OG   1 
ATOM   1135 H  H    . SER A 1 80  ? -19.95636 -15.04099 10.06096  1.000 20.53793 ? 1539 SER A H    1 
ATOM   1136 H  HA   . SER A 1 80  ? -18.26945 -13.31084 11.07706  1.000 22.98257 ? 1539 SER A HA   1 
ATOM   1137 H  HB2  . SER A 1 80  ? -20.06470 -12.56749 12.35825  1.000 27.46717 ? 1539 SER A HB2  1 
ATOM   1138 H  HB3  . SER A 1 80  ? -20.58576 -12.81980 10.87830  1.000 27.46717 ? 1539 SER A HB3  1 
ATOM   1139 H  HG   . SER A 1 80  ? -20.93586 -14.46797 12.91309  1.000 30.36954 ? 1539 SER A HG   1 
ATOM   1140 N  N    A GLU A 1 81  ? -18.26468 -15.99389 12.57273  0.552 20.21805 ? 1540 GLU A N    1 
ATOM   1141 N  N    B GLU A 1 81  ? -18.26120 -15.99330 12.57706  0.448 20.25489 ? 1540 GLU A N    1 
ATOM   1142 C  CA   A GLU A 1 81  ? -17.85188 -16.72064 13.76232  0.552 21.56026 ? 1540 GLU A CA   1 
ATOM   1143 C  CA   B GLU A 1 81  ? -17.83846 -16.71544 13.76494  0.448 21.48131 ? 1540 GLU A CA   1 
ATOM   1144 C  C    A GLU A 1 81  ? -16.65204 -17.63402 13.55206  0.552 20.12852 ? 1540 GLU A C    1 
ATOM   1145 C  C    B GLU A 1 81  ? -16.61068 -17.59165 13.55761  0.448 20.08115 ? 1540 GLU A C    1 
ATOM   1146 O  O    A GLU A 1 81  ? -16.14150 -18.18131 14.54028  0.552 22.39970 ? 1540 GLU A O    1 
ATOM   1147 O  O    B GLU A 1 81  ? -16.02347 -18.04378 14.55062  0.448 22.23916 ? 1540 GLU A O    1 
ATOM   1148 C  CB   A GLU A 1 81  ? -19.00974 -17.58241 14.30284  0.552 24.96325 ? 1540 GLU A CB   1 
ATOM   1149 C  CB   B GLU A 1 81  ? -18.97639 -17.61170 14.28903  0.448 24.68428 ? 1540 GLU A CB   1 
ATOM   1150 C  CG   A GLU A 1 81  ? -20.22495 -16.77917 14.74748  0.552 27.86886 ? 1540 GLU A CG   1 
ATOM   1151 C  CG   B GLU A 1 81  ? -20.31968 -16.90929 14.41094  0.448 27.46092 ? 1540 GLU A CG   1 
ATOM   1152 C  CD   A GLU A 1 81  ? -21.29550 -17.64163 15.38593  0.552 29.96122 ? 1540 GLU A CD   1 
ATOM   1153 C  CD   B GLU A 1 81  ? -20.24098 -15.61195 15.20057  0.448 29.46382 ? 1540 GLU A CD   1 
ATOM   1154 O  OE1  A GLU A 1 81  ? -21.95475 -18.40779 14.65877  0.552 30.31653 ? 1540 GLU A OE1  1 
ATOM   1155 O  OE1  B GLU A 1 81  ? -19.56095 -15.59567 16.25046  0.448 30.21386 ? 1540 GLU A OE1  1 
ATOM   1156 O  OE2  A GLU A 1 81  ? -21.46583 -17.55737 16.62011  0.552 31.37451 ? 1540 GLU A OE2  1 
ATOM   1157 O  OE2  B GLU A 1 81  ? -20.86053 -14.61305 14.77083  0.448 30.85076 ? 1540 GLU A OE2  1 
ATOM   1158 H  H    A GLU A 1 81  ? -18.40430 -16.49092 11.88494  0.552 24.26166 ? 1540 GLU A H    1 
ATOM   1159 H  H    B GLU A 1 81  ? -18.40448 -16.49278 11.89179  0.448 24.30587 ? 1540 GLU A H    1 
ATOM   1160 H  HA   A GLU A 1 81  ? -17.61701 -16.06701 14.43945  0.552 25.87232 ? 1540 GLU A HA   1 
ATOM   1161 H  HA   B GLU A 1 81  ? -17.62688 -16.05915 14.44716  0.448 25.77757 ? 1540 GLU A HA   1 
ATOM   1162 H  HB2  A GLU A 1 81  ? -19.29747 -18.19018 13.60375  0.552 29.95591 ? 1540 GLU A HB2  1 
ATOM   1163 H  HB2  B GLU A 1 81  ? -19.08902 -18.35768 13.67932  0.448 29.62113 ? 1540 GLU A HB2  1 
ATOM   1164 H  HB3  A GLU A 1 81  ? -18.69171 -18.08494 15.06915  0.552 29.95591 ? 1540 GLU A HB3  1 
ATOM   1165 H  HB3  B GLU A 1 81  ? -18.73377 -17.93703 15.17005  0.448 29.62113 ? 1540 GLU A HB3  1 
ATOM   1166 H  HG2  A GLU A 1 81  ? -19.94523 -16.11695 15.39873  0.552 33.44263 ? 1540 GLU A HG2  1 
ATOM   1167 H  HG2  B GLU A 1 81  ? -20.64751 -16.69929 13.52250  0.448 32.95310 ? 1540 GLU A HG2  1 
ATOM   1168 H  HG3  A GLU A 1 81  ? -20.61420 -16.34074 13.97471  0.552 33.44263 ? 1540 GLU A HG3  1 
ATOM   1169 H  HG3  B GLU A 1 81  ? -20.94337 -17.49794 14.86415  0.448 32.95310 ? 1540 GLU A HG3  1 
ATOM   1170 N  N    . ASN A 1 82  ? -16.18901 -17.84333 12.31517  1.000 17.57833 ? 1541 ASN A N    1 
ATOM   1171 C  CA   . ASN A 1 82  ? -15.21409 -18.90361 12.07809  1.000 15.66999 ? 1541 ASN A CA   1 
ATOM   1172 C  C    . ASN A 1 82  ? -13.79794 -18.44553 11.84010  1.000 14.62525 ? 1541 ASN A C    1 
ATOM   1173 O  O    . ASN A 1 82  ? -12.92045 -19.29651 11.65771  1.000 15.49107 ? 1541 ASN A O    1 
ATOM   1174 C  CB   . ASN A 1 82  ? -15.69373 -19.86996 10.99006  1.000 14.57779 ? 1541 ASN A CB   1 
ATOM   1175 C  CG   . ASN A 1 82  ? -15.77310 -19.26608 9.62622   1.000 13.33289 ? 1541 ASN A CG   1 
ATOM   1176 O  OD1  . ASN A 1 82  ? -15.46098 -18.08610 9.43197   1.000 13.03561 ? 1541 ASN A OD1  1 
ATOM   1177 N  ND2  . ASN A 1 82  ? -16.18922 -20.03974 8.65342   1.000 11.64595 ? 1541 ASN A ND2  1 
ATOM   1178 H  H    . ASN A 1 82  ? -16.41921 -17.39580 11.61780  1.000 21.09399 ? 1541 ASN A H    1 
ATOM   1179 H  HA   . ASN A 1 82  ? -15.16469 -19.42242 12.89620  1.000 18.80399 ? 1541 ASN A HA   1 
ATOM   1180 H  HB2  . ASN A 1 82  ? -15.07721 -20.61746 10.94492  1.000 17.49335 ? 1541 ASN A HB2  1 
ATOM   1181 H  HB3  . ASN A 1 82  ? -16.58079 -20.18519 11.22382  1.000 17.49335 ? 1541 ASN A HB3  1 
ATOM   1182 H  HD21 . ASN A 1 82  ? -16.24908 -19.73005 7.85335   1.000 13.97515 ? 1541 ASN A HD21 1 
ATOM   1183 H  HD22 . ASN A 1 82  ? -16.40237 -20.85704 8.81521   1.000 13.97515 ? 1541 ASN A HD22 1 
ATOM   1184 N  N    . ALA A 1 83  ? -13.50881 -17.14230 11.87101  1.000 13.82515 ? 1542 ALA A N    1 
ATOM   1185 C  CA   . ALA A 1 83  ? -12.10653 -16.75169 11.70958  1.000 13.57256 ? 1542 ALA A CA   1 
ATOM   1186 C  C    . ALA A 1 83  ? -11.26411 -17.34814 12.82247  1.000 14.44367 ? 1542 ALA A C    1 
ATOM   1187 O  O    . ALA A 1 83  ? -11.63148 -17.31943 13.99775  1.000 16.26213 ? 1542 ALA A O    1 
ATOM   1188 C  CB   . ALA A 1 83  ? -11.96668 -15.23955 11.68378  1.000 15.24893 ? 1542 ALA A CB   1 
ATOM   1189 H  H    . ALA A 1 83  ? -14.07287 -16.50196 11.97781  1.000 16.59018 ? 1542 ALA A H    1 
ATOM   1190 H  HA   . ALA A 1 83  ? -11.77869 -17.08846 10.86105  1.000 16.28708 ? 1542 ALA A HA   1 
ATOM   1191 H  HB1  . ALA A 1 83  ? -11.03014 -15.01080 11.57670  1.000 18.29872 ? 1542 ALA A HB1  1 
ATOM   1192 H  HB2  . ALA A 1 83  ? -12.48029 -14.88755 10.94000  1.000 18.29872 ? 1542 ALA A HB2  1 
ATOM   1193 H  HB3  . ALA A 1 83  ? -12.30237 -14.87707 12.51853  1.000 18.29872 ? 1542 ALA A HB3  1 
ATOM   1194 N  N    . GLY A 1 84  ? -10.11986 -17.90653 12.43594  1.000 15.44112 ? 1543 GLY A N    1 
ATOM   1195 C  CA   . GLY A 1 84  ? -9.23437  -18.53179 13.39918  1.000 17.37810 ? 1543 GLY A CA   1 
ATOM   1196 C  C    . GLY A 1 84  ? -9.56133  -19.95092 13.77580  1.000 18.14405 ? 1543 GLY A C    1 
ATOM   1197 O  O    . GLY A 1 84  ? -8.84969  -20.50963 14.60080  1.000 20.93901 ? 1543 GLY A O    1 
ATOM   1198 H  H    . GLY A 1 84  ? -9.83955  -17.93348 11.62335  1.000 18.52935 ? 1543 GLY A H    1 
ATOM   1199 H  HA2  . GLY A 1 84  ? -8.33527  -18.52778 13.03516  1.000 20.85372 ? 1543 GLY A HA2  1 
ATOM   1200 H  HA3  . GLY A 1 84  ? -9.24775  -18.00484 14.21345  1.000 20.85372 ? 1543 GLY A HA3  1 
ATOM   1201 N  N    . THR A 1 85  ? -10.60566 -20.53847 13.18196  1.000 15.92278 ? 1544 THR A N    1 
ATOM   1202 C  CA   . THR A 1 85  ? -11.03486 -21.89175 13.50149  1.000 16.52803 ? 1544 THR A CA   1 
ATOM   1203 C  C    . THR A 1 85  ? -10.78213 -22.87240 12.37465  1.000 15.25691 ? 1544 THR A C    1 
ATOM   1204 O  O    . THR A 1 85  ? -11.01170 -24.07693 12.58210  1.000 18.63616 ? 1544 THR A O    1 
ATOM   1205 C  CB   . THR A 1 85  ? -12.54429 -21.95372 13.83629  1.000 17.58865 ? 1544 THR A CB   1 
ATOM   1206 O  OG1  . THR A 1 85  ? -13.34523 -21.78906 12.64833  1.000 16.54919 ? 1544 THR A OG1  1 
ATOM   1207 C  CG2  . THR A 1 85  ? -12.91794 -20.91537 14.90828  1.000 18.78354 ? 1544 THR A CG2  1 
ATOM   1208 H  H    . THR A 1 85  ? -11.08803 -20.16060 12.57853  1.000 19.10734 ? 1544 THR A H    1 
ATOM   1209 H  HA   . THR A 1 85  ? -10.54553 -22.16711 14.29246  1.000 19.83364 ? 1544 THR A HA   1 
ATOM   1210 H  HB   . THR A 1 85  ? -12.74689 -22.82857 14.20302  1.000 21.10638 ? 1544 THR A HB   1 
ATOM   1211 H  HG1  . THR A 1 85  ? -13.18443 -21.04444 12.29435  1.000 19.85903 ? 1544 THR A HG1  1 
ATOM   1212 H  HG21 . THR A 1 85  ? -13.85530 -21.00248 15.14207  1.000 22.54025 ? 1544 THR A HG21 1 
ATOM   1213 H  HG22 . THR A 1 85  ? -12.38090 -21.05240 15.70434  1.000 22.54025 ? 1544 THR A HG22 1 
ATOM   1214 H  HG23 . THR A 1 85  ? -12.75933 -20.01948 14.57192  1.000 22.54025 ? 1544 THR A HG23 1 
ATOM   1215 N  N    . LEU A 1 86  ? -10.34227 -22.42351 11.19800  1.000 13.74358 ? 1545 LEU A N    1 
ATOM   1216 C  CA   . LEU A 1 86  ? -10.29530 -23.23909 9.98933   1.000 14.29094 ? 1545 LEU A CA   1 
ATOM   1217 C  C    . LEU A 1 86  ? -8.88935  -23.77624 9.70463   1.000 15.13322 ? 1545 LEU A C    1 
ATOM   1218 O  O    . LEU A 1 86  ? -8.68479  -24.38936 8.65533   1.000 16.03852 ? 1545 LEU A O    1 
ATOM   1219 C  CB   . LEU A 1 86  ? -10.79180 -22.47033 8.76121   1.000 14.39359 ? 1545 LEU A CB   1 
ATOM   1220 C  CG   . LEU A 1 86  ? -12.22055 -21.93491 8.88115   1.000 14.50421 ? 1545 LEU A CG   1 
ATOM   1221 C  CD1  . LEU A 1 86  ? -12.53970 -21.06863 7.71105   1.000 15.40947 ? 1545 LEU A CD1  1 
ATOM   1222 C  CD2  . LEU A 1 86  ? -13.26230 -23.06145 9.07366   1.000 16.67274 ? 1545 LEU A CD2  1 
ATOM   1223 H  H    . LEU A 1 86  ? -10.05653 -21.62204 11.07308  1.000 16.49230 ? 1545 LEU A H    1 
ATOM   1224 H  HA   . LEU A 1 86  ? -10.90129 -23.98415 10.12561  1.000 17.14913 ? 1545 LEU A HA   1 
ATOM   1225 H  HB2  . LEU A 1 86  ? -10.20542 -21.71162 8.61486   1.000 17.27231 ? 1545 LEU A HB2  1 
ATOM   1226 H  HB3  . LEU A 1 86  ? -10.76421 -23.06372 7.99438   1.000 17.27231 ? 1545 LEU A HB3  1 
ATOM   1227 H  HG   . LEU A 1 86  ? -12.28042 -21.39226 9.68293   1.000 17.40505 ? 1545 LEU A HG   1 
ATOM   1228 H  HD11 . LEU A 1 86  ? -13.44892 -20.74217 7.79848   1.000 18.49137 ? 1545 LEU A HD11 1 
ATOM   1229 H  HD12 . LEU A 1 86  ? -11.92056 -20.32215 7.69256   1.000 18.49137 ? 1545 LEU A HD12 1 
ATOM   1230 H  HD13 . LEU A 1 86  ? -12.45249 -21.59091 6.89833   1.000 18.49137 ? 1545 LEU A HD13 1 
ATOM   1231 H  HD21 . LEU A 1 86  ? -14.15190 -22.67512 9.05719   1.000 20.00729 ? 1545 LEU A HD21 1 
ATOM   1232 H  HD22 . LEU A 1 86  ? -13.16788 -23.70521 8.35425   1.000 20.00729 ? 1545 LEU A HD22 1 
ATOM   1233 H  HD23 . LEU A 1 86  ? -13.10536 -23.49418 9.92748   1.000 20.00729 ? 1545 LEU A HD23 1 
ATOM   1234 N  N    . GLY A 1 87  ? -7.92561  -23.54536 10.59513  1.000 17.73079 ? 1546 GLY A N    1 
ATOM   1235 C  CA   . GLY A 1 87  ? -6.53613  -23.83749 10.26187  1.000 18.37829 ? 1546 GLY A CA   1 
ATOM   1236 C  C    . GLY A 1 87  ? -6.25887  -25.29346 9.96180   1.000 19.06261 ? 1546 GLY A C    1 
ATOM   1237 O  O    . GLY A 1 87  ? -5.40898  -25.60178 9.12140   1.000 20.82057 ? 1546 GLY A O    1 
ATOM   1238 H  H    . GLY A 1 87  ? -8.04779  -23.22602 11.38425  1.000 21.27695 ? 1546 GLY A H    1 
ATOM   1239 H  HA2  . GLY A 1 87  ? -6.28624  -23.32007 9.48038   1.000 22.05395 ? 1546 GLY A HA2  1 
ATOM   1240 H  HA3  . GLY A 1 87  ? -5.97364  -23.57524 11.00734  1.000 22.05395 ? 1546 GLY A HA3  1 
ATOM   1241 N  N    . THR A 1 88  ? -6.96012  -26.20776 10.63241  1.000 20.23643 ? 1547 THR A N    1 
ATOM   1242 C  CA   . THR A 1 88  ? -6.71234  -27.62257 10.42056  1.000 22.24191 ? 1547 THR A CA   1 
ATOM   1243 C  C    . THR A 1 88  ? -7.18915  -28.08197 9.05233   1.000 19.70744 ? 1547 THR A C    1 
ATOM   1244 O  O    . THR A 1 88  ? -6.58676  -28.98768 8.44566   1.000 21.82331 ? 1547 THR A O    1 
ATOM   1245 C  CB   . THR A 1 88  ? -7.39744  -28.44185 11.52594  1.000 26.47402 ? 1547 THR A CB   1 
ATOM   1246 O  OG1  . THR A 1 88  ? -6.81546  -28.07662 12.78675  1.000 30.23218 ? 1547 THR A OG1  1 
ATOM   1247 C  CG2  . THR A 1 88  ? -7.17840  -29.92912 11.30828  1.000 28.73206 ? 1547 THR A CG2  1 
ATOM   1248 H  H    . THR A 1 88  ? -7.57572  -26.03318 11.20700  1.000 24.28372 ? 1547 THR A H    1 
ATOM   1249 H  HA   . THR A 1 88  ? -5.75585  -27.77703 10.46726  1.000 26.69029 ? 1547 THR A HA   1 
ATOM   1250 H  HB   . THR A 1 88  ? -8.35170  -28.26792 11.52097  1.000 31.76883 ? 1547 THR A HB   1 
ATOM   1251 H  HG1  . THR A 1 88  ? -7.17651  -28.51308 13.40703  1.000 36.27861 ? 1547 THR A HG1  1 
ATOM   1252 H  HG21 . THR A 1 88  ? -7.60414  -30.43457 12.01833  1.000 34.47848 ? 1547 THR A HG21 1 
ATOM   1253 H  HG22 . THR A 1 88  ? -7.55858  -30.19949 10.45783  1.000 34.47848 ? 1547 THR A HG22 1 
ATOM   1254 H  HG23 . THR A 1 88  ? -6.22897  -30.12781 11.30607  1.000 34.47848 ? 1547 THR A HG23 1 
ATOM   1255 N  N    . VAL A 1 89  ? -8.31483  -27.54121 8.57741   1.000 15.95969 ? 1548 VAL A N    1 
ATOM   1256 C  CA   . VAL A 1 89  ? -8.91469  -27.97156 7.32670   1.000 14.30947 ? 1548 VAL A CA   1 
ATOM   1257 C  C    . VAL A 1 89  ? -8.62011  -27.04792 6.14646   1.000 12.70924 ? 1548 VAL A C    1 
ATOM   1258 O  O    . VAL A 1 89  ? -8.94784  -27.39559 4.99230   1.000 14.23303 ? 1548 VAL A O    1 
ATOM   1259 C  CB   . VAL A 1 89  ? -10.44189 -28.20255 7.48284   1.000 17.71235 ? 1548 VAL A CB   1 
ATOM   1260 C  CG1  . VAL A 1 89  ? -10.69953 -29.32071 8.51176   1.000 18.78881 ? 1548 VAL A CG1  1 
ATOM   1261 C  CG2  . VAL A 1 89  ? -11.14497 -26.89867 7.88064   1.000 17.38075 ? 1548 VAL A CG2  1 
ATOM   1262 H  H    . VAL A 1 89  ? -8.75184  -26.91434 8.97194   1.000 19.15163 ? 1548 VAL A H    1 
ATOM   1263 H  HA   . VAL A 1 89  ? -8.51629  -28.82510 7.09510   1.000 17.17136 ? 1548 VAL A HA   1 
ATOM   1264 H  HB   . VAL A 1 89  ? -10.81705 -28.48463 6.63397   1.000 21.25482 ? 1548 VAL A HB   1 
ATOM   1265 H  HG11 . VAL A 1 89  ? -11.65507 -29.47297 8.58006   1.000 22.54657 ? 1548 VAL A HG11 1 
ATOM   1266 H  HG12 . VAL A 1 89  ? -10.25583 -30.13082 8.21552   1.000 22.54657 ? 1548 VAL A HG12 1 
ATOM   1267 H  HG13 . VAL A 1 89  ? -10.34607 -29.04569 9.37218   1.000 22.54657 ? 1548 VAL A HG13 1 
ATOM   1268 H  HG21 . VAL A 1 89  ? -12.09836 -27.06284 7.95139   1.000 20.85690 ? 1548 VAL A HG21 1 
ATOM   1269 H  HG22 . VAL A 1 89  ? -10.79646 -26.59995 8.73516   1.000 20.85690 ? 1548 VAL A HG22 1 
ATOM   1270 H  HG23 . VAL A 1 89  ? -10.97437 -26.22785 7.20108   1.000 20.85690 ? 1548 VAL A HG23 1 
ATOM   1271 N  N    . ALA A 1 90  ? -7.98352  -25.88330 6.37949   1.000 12.22760 ? 1549 ALA A N    1 
ATOM   1272 C  CA   . ALA A 1 90  ? -7.86579  -24.90985 5.30080   1.000 12.51702 ? 1549 ALA A CA   1 
ATOM   1273 C  C    . ALA A 1 90  ? -7.16978  -25.45770 4.07195   1.000 12.35918 ? 1549 ALA A C    1 
ATOM   1274 O  O    . ALA A 1 90  ? -7.58370  -25.19353 2.93981   1.000 12.80653 ? 1549 ALA A O    1 
ATOM   1275 C  CB   . ALA A 1 90  ? -7.07853  -23.70342 5.82491   1.000 12.89601 ? 1549 ALA A CB   1 
ATOM   1276 H  H    . ALA A 1 90  ? -7.62797  -25.65001 7.12700   1.000 14.67311 ? 1549 ALA A H    1 
ATOM   1277 H  HA   . ALA A 1 90  ? -8.76071  -24.65169 5.02991   1.000 15.02043 ? 1549 ALA A HA   1 
ATOM   1278 H  HB1  . ALA A 1 90  ? -6.99269  -23.04926 5.11386   1.000 15.47521 ? 1549 ALA A HB1  1 
ATOM   1279 H  HB2  . ALA A 1 90  ? -7.55650  -23.31604 6.57484   1.000 15.47521 ? 1549 ALA A HB2  1 
ATOM   1280 H  HB3  . ALA A 1 90  ? -6.19986  -23.99937 6.10996   1.000 15.47521 ? 1549 ALA A HB3  1 
ATOM   1281 N  N    . GLY A 1 91  ? -6.09209  -26.21382 4.26339   1.000 11.71698 ? 1550 GLY A N    1 
ATOM   1282 C  CA   . GLY A 1 91  ? -5.36067  -26.71663 3.13063   1.000 11.16422 ? 1550 GLY A CA   1 
ATOM   1283 C  C    . GLY A 1 91  ? -6.08197  -27.75564 2.30992   1.000 11.19850 ? 1550 GLY A C    1 
ATOM   1284 O  O    . GLY A 1 91  ? -5.67045  -28.01231 1.17019   1.000 12.42749 ? 1550 GLY A O    1 
ATOM   1285 H  H    . GLY A 1 91  ? -5.77707  -26.44069 5.03078   1.000 14.06038 ? 1550 GLY A H    1 
ATOM   1286 H  HA2  . GLY A 1 91  ? -5.14930  -25.97339 2.54427   1.000 13.39706 ? 1550 GLY A HA2  1 
ATOM   1287 H  HA3  . GLY A 1 91  ? -4.53437  -27.11377 3.44752   1.000 13.39706 ? 1550 GLY A HA3  1 
ATOM   1288 N  N    A SER A 1 92  ? -7.17796  -28.29930 2.82199   0.906 10.78007 ? 1551 SER A N    1 
ATOM   1289 C  CA   A SER A 1 92  ? -7.96308  -29.25599 2.06891   0.906 11.75119 ? 1551 SER A CA   1 
ATOM   1290 C  CA   B SER A 1 92  ? -8.18881  -30.00399 1.81840   0.094 15.93059 ? 1551 SER A CA   1 
ATOM   1291 C  C    A SER A 1 92  ? -9.00205  -28.59223 1.17666   0.906 10.47742 ? 1551 SER A C    1 
ATOM   1292 O  O    A SER A 1 92  ? -9.63340  -29.27982 0.39764   0.906 11.19847 ? 1551 SER A O    1 
ATOM   1293 C  CB   A SER A 1 92  ? -8.62338  -30.22192 3.02285   0.906 14.66467 ? 1551 SER A CB   1 
ATOM   1294 C  CB   B SER A 1 92  ? -8.92342  -30.40249 3.09692   0.094 15.44367 ? 1551 SER A CB   1 
ATOM   1295 O  OG   A SER A 1 92  ? -9.69295  -29.65624 3.66867   0.906 17.53333 ? 1551 SER A OG   1 
ATOM   1296 O  OG   B SER A 1 92  ? -8.00223  -30.77841 4.10460   0.094 13.64357 ? 1551 SER A OG   1 
ATOM   1297 H  H    A SER A 1 92  ? -7.48565  -28.12741 3.60645   0.906 12.93608 ? 1551 SER A H    1 
ATOM   1298 H  H    B SER A 1 92  ? -7.33507  -28.73046 4.48161   0.094 0.00008  ? 1551 SER A H    1 
ATOM   1299 H  HA   A SER A 1 92  ? -7.38213  -29.77174 1.48805   0.906 14.10142 ? 1551 SER A HA   1 
ATOM   1300 H  HA   B SER A 1 92  ? -7.25998  -30.27458 1.88822   0.094 19.11670 ? 1551 SER A HA   1 
ATOM   1301 H  HB2  A SER A 1 92  ? -8.93457  -30.99129 2.52071   0.906 17.59761 ? 1551 SER A HB2  1 
ATOM   1302 H  HB2  B SER A 1 92  ? -9.44537  -29.64750 3.41069   0.094 18.53240 ? 1551 SER A HB2  1 
ATOM   1303 H  HB3  A SER A 1 92  ? -7.97142  -30.49965 3.68520   0.906 17.59761 ? 1551 SER A HB3  1 
ATOM   1304 H  HB3  B SER A 1 92  ? -9.50742  -31.15303 2.90577   0.094 18.53240 ? 1551 SER A HB3  1 
ATOM   1305 H  HG   A SER A 1 92  ? -9.44036  -28.99000 4.11356   0.906 21.04000 ? 1551 SER A HG   1 
ATOM   1306 H  HG   B SER A 1 92  ? -7.53914  -31.42838 3.84253   0.094 16.37228 ? 1551 SER A HG   1 
ATOM   1307 N  N    . ALA A 1 93  ? -9.17222  -27.27815 1.27291   1.000 11.12208 ? 1552 ALA A N    1 
ATOM   1308 C  CA   . ALA A 1 93  ? -10.17879 -26.56097 0.49883   1.000 10.60895 ? 1552 ALA A CA   1 
ATOM   1309 C  C    . ALA A 1 93  ? -9.57521  -25.93989 -0.75015  1.000 9.97737  ? 1552 ALA A C    1 
ATOM   1310 O  O    . ALA A 1 93  ? -8.35467  -25.71776 -0.82288  1.000 11.15370 ? 1552 ALA A O    1 
ATOM   1311 C  CB   . ALA A 1 93  ? -10.77199 -25.47946 1.39694   1.000 12.21428 ? 1552 ALA A CB   1 
ATOM   1312 H  H    . ALA A 1 93  ? -8.70799  -26.77094 1.78947   1.000 13.34650 ? 1552 ALA A H    1 
ATOM   1313 H  HA   . ALA A 1 93  ? -10.87538 -27.16424 0.19596   1.000 12.73074 ? 1552 ALA A HA   1 
ATOM   1314 H  HB1  . ALA A 1 93  ? -11.44788 -24.99221 0.90030   1.000 14.65713 ? 1552 ALA A HB1  1 
ATOM   1315 H  HB2  . ALA A 1 93  ? -11.17143 -25.89907 2.17493   1.000 14.65713 ? 1552 ALA A HB2  1 
ATOM   1316 H  HB3  . ALA A 1 93  ? -10.06496 -24.87557 1.67324   1.000 14.65713 ? 1552 ALA A HB3  1 
ATOM   1317 N  N    . ALA A 1 94  ? -10.42994 -25.59050 -1.69354  1.000 10.60888 ? 1553 ALA A N    1 
ATOM   1318 C  CA   . ALA A 1 94  ? -10.01805 -24.77865 -2.84448  1.000 10.44837 ? 1553 ALA A CA   1 
ATOM   1319 C  C    . ALA A 1 94  ? -9.38845  -23.46786 -2.38441  1.000 9.46152  ? 1553 ALA A C    1 
ATOM   1320 O  O    . ALA A 1 94  ? -8.38194  -23.00592 -2.93919  1.000 11.07469 ? 1553 ALA A O    1 
ATOM   1321 C  CB   . ALA A 1 94  ? -11.20656 -24.46908 -3.75425  1.000 10.11151 ? 1553 ALA A CB   1 
ATOM   1322 H  H    . ALA A 1 94  ? -11.26224 -25.80688 -1.70047  1.000 12.73066 ? 1553 ALA A H    1 
ATOM   1323 H  HA   . ALA A 1 94  ? -9.37175  -25.29176 -3.35430  1.000 12.53805 ? 1553 ALA A HA   1 
ATOM   1324 H  HB1  . ALA A 1 94  ? -10.90041 -23.93270 -4.50223  1.000 12.13381 ? 1553 ALA A HB1  1 
ATOM   1325 H  HB2  . ALA A 1 94  ? -11.58269 -25.30285 -4.07715  1.000 12.13381 ? 1553 ALA A HB2  1 
ATOM   1326 H  HB3  . ALA A 1 94  ? -11.87329 -23.97980 -3.24731  1.000 12.13381 ? 1553 ALA A HB3  1 
ATOM   1327 N  N    . GLY A 1 95  ? -9.99011  -22.87595 -1.36167  1.000 10.26148 ? 1554 GLY A N    1 
ATOM   1328 C  CA   . GLY A 1 95  ? -9.63934  -21.56066 -0.86416  1.000 9.54304  ? 1554 GLY A CA   1 
ATOM   1329 C  C    . GLY A 1 95  ? -10.72283 -21.12183 0.10917   1.000 9.57720  ? 1554 GLY A C    1 
ATOM   1330 O  O    . GLY A 1 95  ? -11.63174 -21.91579 0.44278   1.000 9.37193  ? 1554 GLY A O    1 
ATOM   1331 H  H    . GLY A 1 95  ? -10.63492 -23.23366 -0.91911  1.000 12.31377 ? 1554 GLY A H    1 
ATOM   1332 H  HA2  . GLY A 1 95  ? -8.78483  -21.58893 -0.40600  1.000 11.45164 ? 1554 GLY A HA2  1 
ATOM   1333 H  HA3  . GLY A 1 95  ? -9.58473  -20.92571 -1.59544  1.000 11.45164 ? 1554 GLY A HA3  1 
ATOM   1334 N  N    . LEU A 1 96  ? -10.64648 -19.85762 0.52195   1.000 9.77985  ? 1555 LEU A N    1 
ATOM   1335 C  CA   . LEU A 1 96  ? -11.64781 -19.25008 1.37189   1.000 9.23512  ? 1555 LEU A CA   1 
ATOM   1336 C  C    . LEU A 1 96  ? -12.39607 -18.21464 0.55536   1.000 9.53778  ? 1555 LEU A C    1 
ATOM   1337 O  O    . LEU A 1 96  ? -11.81079 -17.32758 -0.07664  1.000 9.95354  ? 1555 LEU A O    1 
ATOM   1338 C  CB   . LEU A 1 96  ? -10.97400 -18.56653 2.57555   1.000 9.51403  ? 1555 LEU A CB   1 
ATOM   1339 C  CG   . LEU A 1 96  ? -11.90578 -17.92616 3.57606   1.000 10.02210 ? 1555 LEU A CG   1 
ATOM   1340 C  CD1  . LEU A 1 96  ? -12.72310 -18.93577 4.32863   1.000 10.46416 ? 1555 LEU A CD1  1 
ATOM   1341 C  CD2  . LEU A 1 96  ? -11.09009 -17.07230 4.55992   1.000 12.00637 ? 1555 LEU A CD2  1 
ATOM   1342 H  H    . LEU A 1 96  ? -10.00546 -19.32323 0.31432   1.000 11.73582 ? 1555 LEU A H    1 
ATOM   1343 H  HA   . LEU A 1 96  ? -12.26353 -19.91692 1.71411   1.000 11.08214 ? 1555 LEU A HA   1 
ATOM   1344 H  HB2  . LEU A 1 96  ? -10.45527 -19.23381 3.05153   1.000 11.41683 ? 1555 LEU A HB2  1 
ATOM   1345 H  HB3  . LEU A 1 96  ? -10.38926 -17.86928 2.23966   1.000 11.41683 ? 1555 LEU A HB3  1 
ATOM   1346 H  HG   . LEU A 1 96  ? -12.53198 -17.36596 3.09135   1.000 12.02652 ? 1555 LEU A HG   1 
ATOM   1347 H  HD11 . LEU A 1 96  ? -13.27555 -18.47375 4.97843   1.000 12.55699 ? 1555 LEU A HD11 1 
ATOM   1348 H  HD12 . LEU A 1 96  ? -13.28382 -19.41882 3.70161   1.000 12.55699 ? 1555 LEU A HD12 1 
ATOM   1349 H  HD13 . LEU A 1 96  ? -12.12574 -19.55189 4.78080   1.000 12.55699 ? 1555 LEU A HD13 1 
ATOM   1350 H  HD21 . LEU A 1 96  ? -11.69328 -16.67035 5.20452   1.000 14.40764 ? 1555 LEU A HD21 1 
ATOM   1351 H  HD22 . LEU A 1 96  ? -10.44981 -17.64075 5.01578   1.000 14.40764 ? 1555 LEU A HD22 1 
ATOM   1352 H  HD23 . LEU A 1 96  ? -10.62440 -16.37949 4.06592   1.000 14.40764 ? 1555 LEU A HD23 1 
HETATM 1353 N  N    . KCX A 1 97  ? -13.73124 -18.30708 0.58361   1.000 10.14309 ? 1556 KCX A N    1 
HETATM 1354 C  CA   . KCX A 1 97  ? -14.64519 -17.38046 -0.10192  1.000 9.26664  ? 1556 KCX A CA   1 
HETATM 1355 C  CB   . KCX A 1 97  ? -15.77215 -18.13657 -0.78604  1.000 9.89570  ? 1556 KCX A CB   1 
HETATM 1356 C  CG   . KCX A 1 97  ? -16.89333 -17.26800 -1.37119  1.000 10.74832 ? 1556 KCX A CG   1 
HETATM 1357 C  CD   . KCX A 1 97  ? -16.46079 -16.39956 -2.55805  1.000 9.63514  ? 1556 KCX A CD   1 
HETATM 1358 C  CE   . KCX A 1 97  ? -17.58997 -15.67011 -3.28518  1.000 9.57982  ? 1556 KCX A CE   1 
HETATM 1359 N  NZ   . KCX A 1 97  ? -18.51101 -16.60857 -3.87475  1.000 9.79304  ? 1556 KCX A NZ   1 
HETATM 1360 C  C    . KCX A 1 97  ? -15.25855 -16.42975 0.90563   1.000 8.20343  ? 1556 KCX A C    1 
HETATM 1361 O  O    . KCX A 1 97  ? -15.83643 -16.84364 1.90358   1.000 9.63507  ? 1556 KCX A O    1 
HETATM 1362 C  CX   . KCX A 1 97  ? -19.55106 -16.24454 -4.62320  1.000 9.48248  ? 1556 KCX A CX   1 
HETATM 1363 O  OQ1  . KCX A 1 97  ? -19.59987 -15.01396 -4.98157  1.000 9.26929  ? 1556 KCX A OQ1  1 
HETATM 1364 O  OQ2  . KCX A 1 97  ? -20.41607 -17.13359 -4.93005  1.000 9.60351  ? 1556 KCX A OQ2  1 
HETATM 1365 H  H    . KCX A 1 97  ? -14.15176 -18.92371 1.01084   1.000 12.17171 ? 1556 KCX A H    1 
HETATM 1366 H  HA   . KCX A 1 97  ? -14.21115 -16.94944 -0.69211  1.000 11.11996 ? 1556 KCX A HA   1 
HETATM 1367 H  HB2  . KCX A 1 97  ? -16.12766 -18.65827 -0.21689  1.000 11.87485 ? 1556 KCX A HB2  1 
HETATM 1368 H  HB3  . KCX A 1 97  ? -15.44122 -18.58702 -1.42641  1.000 11.87485 ? 1556 KCX A HB3  1 
HETATM 1369 H  HG2  . KCX A 1 97  ? -17.18061 -16.74795 -0.76330  1.000 12.89799 ? 1556 KCX A HG2  1 
HETATM 1370 H  HG3  . KCX A 1 97  ? -17.51991 -17.77601 -1.63919  1.000 12.89799 ? 1556 KCX A HG3  1 
HETATM 1371 H  HD2  . KCX A 1 97  ? -16.07423 -16.89776 -3.12802  1.000 11.56217 ? 1556 KCX A HD2  1 
HETATM 1372 H  HD3  . KCX A 1 97  ? -15.91997 -15.80823 -2.27458  1.000 11.56217 ? 1556 KCX A HD3  1 
HETATM 1373 H  HE2  . KCX A 1 97  ? -17.26348 -15.18761 -3.90413  1.000 11.49579 ? 1556 KCX A HE2  1 
HETATM 1374 H  HE3  . KCX A 1 97  ? -18.01618 -15.18491 -2.73253  1.000 11.49579 ? 1556 KCX A HE3  1 
HETATM 1375 H  HZ   . KCX A 1 97  ? -18.38398 -17.43778 -3.73775  1.000 11.75165 ? 1556 KCX A HZ   1 
ATOM   1376 N  N    . LEU A 1 98  ? -15.12592 -15.11428 0.60940   1.000 9.41408  ? 1557 LEU A N    1 
ATOM   1377 C  CA   . LEU A 1 98  ? -15.77963 -14.02186 1.37218   1.000 9.30354  ? 1557 LEU A CA   1 
ATOM   1378 C  C    . LEU A 1 98  ? -16.94869 -13.48238 0.53345   1.000 8.74298  ? 1557 LEU A C    1 
ATOM   1379 O  O    . LEU A 1 98  ? -16.78472 -13.09725 -0.60374  1.000 9.67192  ? 1557 LEU A O    1 
ATOM   1380 C  CB   . LEU A 1 98  ? -14.80028 -12.88865 1.64673   1.000 11.37751 ? 1557 LEU A CB   1 
ATOM   1381 C  CG   . LEU A 1 98  ? -13.89321 -13.12451 2.89750   1.000 15.72795 ? 1557 LEU A CG   1 
ATOM   1382 C  CD1  . LEU A 1 98  ? -12.96307 -14.22815 2.77426   1.000 16.39375 ? 1557 LEU A CD1  1 
ATOM   1383 C  CD2  . LEU A 1 98  ? -13.13416 -11.84554 3.16674   1.000 18.19923 ? 1557 LEU A CD2  1 
ATOM   1384 H  H    . LEU A 1 98  ? -14.65073 -14.82194 -0.04507  1.000 11.29689 ? 1557 LEU A H    1 
ATOM   1385 H  HA   . LEU A 1 98  ? -16.09353 -14.35234 2.22842   1.000 11.16425 ? 1557 LEU A HA   1 
ATOM   1386 H  HB2  . LEU A 1 98  ? -14.22069 -12.78544 0.87580   1.000 13.65301 ? 1557 LEU A HB2  1 
ATOM   1387 H  HB3  . LEU A 1 98  ? -15.30323 -12.07264 1.79528   1.000 13.65301 ? 1557 LEU A HB3  1 
ATOM   1388 H  HG   . LEU A 1 98  ? -14.47051 -13.36944 3.63753   1.000 18.87354 ? 1557 LEU A HG   1 
ATOM   1389 H  HD11 . LEU A 1 98  ? -12.43700 -14.29002 3.58687   1.000 19.67250 ? 1557 LEU A HD11 1 
ATOM   1390 H  HD12 . LEU A 1 98  ? -13.46266 -15.04875 2.64036   1.000 19.67250 ? 1557 LEU A HD12 1 
ATOM   1391 H  HD13 . LEU A 1 98  ? -12.38122 -14.06748 2.01497   1.000 19.67250 ? 1557 LEU A HD13 1 
ATOM   1392 H  HD21 . LEU A 1 98  ? -12.56949 -11.97137 3.94534   1.000 21.83908 ? 1557 LEU A HD21 1 
ATOM   1393 H  HD22 . LEU A 1 98  ? -12.58861 -11.63330 2.39329   1.000 21.83908 ? 1557 LEU A HD22 1 
ATOM   1394 H  HD23 . LEU A 1 98  ? -13.76860 -11.13026 3.33036   1.000 21.83908 ? 1557 LEU A HD23 1 
ATOM   1395 N  N    . TYR A 1 99  ? -18.11774 -13.44915 1.15131   1.000 9.90357  ? 1558 TYR A N    1 
ATOM   1396 C  CA   . TYR A 1 99  ? -19.29155 -12.79631 0.57951   1.000 9.97989  ? 1558 TYR A CA   1 
ATOM   1397 C  C    . TYR A 1 99  ? -19.36898 -11.42176 1.20437   1.000 9.52464  ? 1558 TYR A C    1 
ATOM   1398 O  O    . TYR A 1 99  ? -19.74809 -11.30634 2.36701   1.000 10.71680 ? 1558 TYR A O    1 
ATOM   1399 C  CB   . TYR A 1 99  ? -20.55953 -13.60103 0.89582   1.000 9.81934  ? 1558 TYR A CB   1 
ATOM   1400 C  CG   . TYR A 1 99  ? -20.68365 -14.83721 0.03215   1.000 9.46672  ? 1558 TYR A CG   1 
ATOM   1401 C  CD1  . TYR A 1 99  ? -21.23742 -14.78494 -1.22696  1.000 9.53772  ? 1558 TYR A CD1  1 
ATOM   1402 C  CD2  . TYR A 1 99  ? -20.18765 -16.09910 0.45716   1.000 9.75090  ? 1558 TYR A CD2  1 
ATOM   1403 C  CE1  . TYR A 1 99  ? -21.31185 -15.87783 -2.04874  1.000 10.03776 ? 1558 TYR A CE1  1 
ATOM   1404 C  CE2  . TYR A 1 99  ? -20.27511 -17.19043 -0.35070  1.000 10.31677 ? 1558 TYR A CE2  1 
ATOM   1405 C  CZ   . TYR A 1 99  ? -20.81541 -17.09306 -1.59757  1.000 9.91681  ? 1558 TYR A CZ   1 
ATOM   1406 O  OH   . TYR A 1 99  ? -20.81360 -18.21770 -2.41705  1.000 10.99577 ? 1558 TYR A OH   1 
ATOM   1407 H  H    . TYR A 1 99  ? -18.26280 -13.80497 1.92070   1.000 11.88428 ? 1558 TYR A H    1 
ATOM   1408 H  HA   . TYR A 1 99  ? -19.20693 -12.72116 -0.38387  1.000 11.97587 ? 1558 TYR A HA   1 
ATOM   1409 H  HB2  . TYR A 1 99  ? -20.53437 -13.88175 1.82397   1.000 11.78321 ? 1558 TYR A HB2  1 
ATOM   1410 H  HB3  . TYR A 1 99  ? -21.33732 -13.04306 0.73894   1.000 11.78321 ? 1558 TYR A HB3  1 
ATOM   1411 H  HD1  . TYR A 1 99  ? -21.57498 -13.97389 -1.53216  1.000 11.44526 ? 1558 TYR A HD1  1 
ATOM   1412 H  HD2  . TYR A 1 99  ? -19.79843 -16.18007 1.29791   1.000 11.70109 ? 1558 TYR A HD2  1 
ATOM   1413 H  HE1  . TYR A 1 99  ? -21.68908 -15.80697 -2.89584  1.000 12.04531 ? 1558 TYR A HE1  1 
ATOM   1414 H  HE2  . TYR A 1 99  ? -19.96243 -18.01240 -0.04821  1.000 12.38012 ? 1558 TYR A HE2  1 
ATOM   1415 H  HH   . TYR A 1 99  ? -21.09087 -18.01504 -3.18363  1.000 13.19493 ? 1558 TYR A HH   1 
ATOM   1416 N  N    . LEU A 1 100 ? -19.04874 -10.37849 0.42386   1.000 10.73525 ? 1559 LEU A N    1 
ATOM   1417 C  CA   . LEU A 1 100 ? -18.96292 -9.02014  0.99524   1.000 11.32216 ? 1559 LEU A CA   1 
ATOM   1418 C  C    . LEU A 1 100 ? -20.11288 -8.13218  0.59441   1.000 11.73811 ? 1559 LEU A C    1 
ATOM   1419 O  O    . LEU A 1 100 ? -20.13946 -6.97713  1.02349   1.000 14.83827 ? 1559 LEU A O    1 
ATOM   1420 C  CB   . LEU A 1 100 ? -17.61596 -8.37773  0.64363   1.000 11.12223 ? 1559 LEU A CB   1 
ATOM   1421 C  CG   . LEU A 1 100 ? -16.41911 -9.22219  1.06686   1.000 12.88020 ? 1559 LEU A CG   1 
ATOM   1422 C  CD1  . LEU A 1 100 ? -15.08439 -8.47356  0.70426   1.000 12.26966 ? 1559 LEU A CD1  1 
ATOM   1423 C  CD2  . LEU A 1 100 ? -16.41924 -9.54876  2.53599   1.000 14.50407 ? 1559 LEU A CD2  1 
ATOM   1424 H  H    . LEU A 1 100 ? -18.88076 -10.42897 -0.41806  1.000 12.88230 ? 1559 LEU A H    1 
ATOM   1425 H  HA   . LEU A 1 100 ? -18.99334 -9.08688  1.96247   1.000 13.58659 ? 1559 LEU A HA   1 
ATOM   1426 H  HB2  . LEU A 1 100 ? -17.56948 -8.25330  -0.31724  1.000 13.34667 ? 1559 LEU A HB2  1 
ATOM   1427 H  HB3  . LEU A 1 100 ? -17.55096 -7.52040  1.09270   1.000 13.34667 ? 1559 LEU A HB3  1 
ATOM   1428 H  HG   . LEU A 1 100 ? -16.47632 -10.06404 0.58841   1.000 15.45624 ? 1559 LEU A HG   1 
ATOM   1429 H  HD11 . LEU A 1 100 ? -14.33129 -9.02669  0.96462   1.000 14.72359 ? 1559 LEU A HD11 1 
ATOM   1430 H  HD12 . LEU A 1 100 ? -15.06203 -8.31323  -0.25214  1.000 14.72359 ? 1559 LEU A HD12 1 
ATOM   1431 H  HD13 . LEU A 1 100 ? -15.05580 -7.62977  1.18185   1.000 14.72359 ? 1559 LEU A HD13 1 
ATOM   1432 H  HD21 . LEU A 1 100 ? -15.54458 -9.88658  2.78448   1.000 17.40488 ? 1559 LEU A HD21 1 
ATOM   1433 H  HD22 . LEU A 1 100 ? -16.61771 -8.74319  3.03855   1.000 17.40488 ? 1559 LEU A HD22 1 
ATOM   1434 H  HD23 . LEU A 1 100 ? -17.09551 -10.22208 2.70978   1.000 17.40488 ? 1559 LEU A HD23 1 
ATOM   1435 N  N    A ASN A 1 101 ? -21.01650 -8.60090  -0.25865  0.566 10.68532 ? 1560 ASN A N    1 
ATOM   1436 N  N    B ASN A 1 101 ? -21.02363 -8.60176  -0.23238  0.434 12.60922 ? 1560 ASN A N    1 
ATOM   1437 C  CA   A ASN A 1 101 ? -22.19611 -7.86338  -0.68805  0.566 11.29063 ? 1560 ASN A CA   1 
ATOM   1438 C  CA   B ASN A 1 101 ? -22.24041 -7.86140  -0.52312  0.434 14.45152 ? 1560 ASN A CA   1 
ATOM   1439 C  C    A ASN A 1 101 ? -23.42470 -8.76229  -0.62120  0.566 14.38307 ? 1560 ASN A C    1 
ATOM   1440 C  C    B ASN A 1 101 ? -23.42000 -8.70897  -0.06364  0.434 16.54392 ? 1560 ASN A C    1 
ATOM   1441 O  O    A ASN A 1 101 ? -23.31855 -9.97603  -0.42442  0.566 18.53604 ? 1560 ASN A O    1 
ATOM   1442 O  O    B ASN A 1 101 ? -23.36515 -9.27084  1.04427   0.434 16.05437 ? 1560 ASN A O    1 
ATOM   1443 C  CB   A ASN A 1 101 ? -22.09120 -7.35079  -2.12112  0.566 9.68515  ? 1560 ASN A CB   1 
ATOM   1444 C  CB   B ASN A 1 101 ? -22.27909 -7.45445  -1.98507  0.434 14.63044 ? 1560 ASN A CB   1 
ATOM   1445 C  CG   A ASN A 1 101 ? -20.86414 -6.53531  -2.37263  0.566 9.35883  ? 1560 ASN A CG   1 
ATOM   1446 C  CG   B ASN A 1 101 ? -21.05124 -6.64158  -2.40224  0.434 14.45678 ? 1560 ASN A CG   1 
ATOM   1447 O  OD1  A ASN A 1 101 ? -19.88236 -7.01708  -2.91728  0.566 9.61671  ? 1560 ASN A OD1  1 
ATOM   1448 O  OD1  B ASN A 1 101 ? -20.10235 -7.15987  -2.97958  0.434 14.25937 ? 1560 ASN A OD1  1 
ATOM   1449 N  ND2  A ASN A 1 101 ? -20.91258 -5.27130  -1.97805  0.566 11.65111 ? 1560 ASN A ND2  1 
ATOM   1450 N  ND2  B ASN A 1 101 ? -21.07439 -5.35421  -2.08950  0.434 15.96742 ? 1560 ASN A ND2  1 
ATOM   1451 H  H    A ASN A 1 101 ? -20.96471 -9.38025  -0.61855  0.566 12.82239 ? 1560 ASN A H    1 
ATOM   1452 H  H    B ASN A 1 101 ? -20.96382 -9.35435  -0.64425  0.434 15.13106 ? 1560 ASN A H    1 
ATOM   1453 H  HA   A ASN A 1 101 ? -22.28969 -7.11168  -0.08217  0.566 13.54875 ? 1560 ASN A HA   1 
ATOM   1454 H  HA   B ASN A 1 101 ? -22.28987 -7.01836  -0.04591  0.434 17.34182 ? 1560 ASN A HA   1 
ATOM   1455 H  HB2  A ASN A 1 101 ? -22.07237 -8.10973  -2.72490  0.566 11.62218 ? 1560 ASN A HB2  1 
ATOM   1456 H  HB2  B ASN A 1 101 ? -22.31220 -8.25268  -2.53520  0.434 17.55653 ? 1560 ASN A HB2  1 
ATOM   1457 H  HB3  A ASN A 1 101 ? -22.86217 -6.79397  -2.31208  0.566 11.62218 ? 1560 ASN A HB3  1 
ATOM   1458 H  HB3  B ASN A 1 101 ? -23.06694 -6.91069  -2.14168  0.434 17.55653 ? 1560 ASN A HB3  1 
ATOM   1459 H  HD21 A ASN A 1 101 ? -20.23392 -4.75697  -2.09837  0.566 13.98134 ? 1560 ASN A HD21 1 
ATOM   1460 H  HD21 B ASN A 1 101 ? -20.41103 -4.84873  -2.29936  0.434 19.16091 ? 1560 ASN A HD21 1 
ATOM   1461 H  HD22 A ASN A 1 101 ? -21.62269 -4.96525  -1.60164  0.566 13.98134 ? 1560 ASN A HD22 1 
ATOM   1462 H  HD22 B ASN A 1 101 ? -21.75277 -5.02413  -1.67666  0.434 19.16091 ? 1560 ASN A HD22 1 
ATOM   1463 N  N    A GLU A 1 102 ? -24.60171 -8.16347  -0.82685  0.566 13.97780 ? 1561 GLU A N    1 
ATOM   1464 N  N    B GLU A 1 102 ? -24.45784 -8.82897  -0.89073  0.434 21.09961 ? 1561 GLU A N    1 
ATOM   1465 C  CA   A GLU A 1 102 ? -25.85574 -8.91514  -0.81096  0.566 15.98908 ? 1561 GLU A CA   1 
ATOM   1466 C  CA   B GLU A 1 102 ? -25.63665 -9.60976  -0.50932  0.434 24.49772 ? 1561 GLU A CA   1 
ATOM   1467 C  C    A GLU A 1 102 ? -25.96773 -9.77979  -2.06455  0.566 14.32249 ? 1561 GLU A C    1 
ATOM   1468 C  C    B GLU A 1 102 ? -25.29276 -11.09204 -0.35627  0.434 25.55280 ? 1561 GLU A C    1 
ATOM   1469 O  O    A GLU A 1 102 ? -25.71839 -9.32084  -3.18490  0.566 14.36993 ? 1561 GLU A O    1 
ATOM   1470 O  O    B GLU A 1 102 ? -24.56589 -11.67190 -1.17370  0.434 25.73178 ? 1561 GLU A O    1 
ATOM   1471 C  CB   A GLU A 1 102 ? -27.04319 -7.94384  -0.77324  0.566 29.89200 ? 1561 GLU A CB   1 
ATOM   1472 C  CB   B GLU A 1 102 ? -26.73150 -9.44800  -1.57390  0.434 29.94502 ? 1561 GLU A CB   1 
ATOM   1473 H  H    A GLU A 1 102 ? -24.69971 -7.32250  -0.97774  0.566 16.77336 ? 1561 GLU A H    1 
ATOM   1474 H  H    B GLU A 1 102 ? -24.50572 -8.47207  -1.67171  0.434 25.31954 ? 1561 GLU A H    1 
ATOM   1475 H  HA   A GLU A 1 102 ? -25.87649 -9.48463  -0.02601  0.566 19.18689 ? 1561 GLU A HA   1 
ATOM   1476 H  HA   B GLU A 1 102 ? -25.96718 -9.28589  0.34318   0.434 29.39726 ? 1561 GLU A HA   1 
ATOM   1477 N  N    A THR A 1 103 ? -26.30079 -11.05693 -1.86425  0.566 12.02237 ? 1562 THR A N    1 
ATOM   1478 N  N    B THR A 1 103 ? -25.82393 -11.70832 0.69919   0.434 26.01083 ? 1562 THR A N    1 
ATOM   1479 C  CA   A THR A 1 103 ? -26.46361 -12.01381 -2.96377  0.566 12.73642 ? 1562 THR A CA   1 
ATOM   1480 C  CA   B THR A 1 103 ? -25.63861 -13.13672 0.92231   0.434 27.57956 ? 1562 THR A CA   1 
ATOM   1481 C  C    A THR A 1 103 ? -27.15003 -13.23434 -2.37590  0.566 12.42763 ? 1562 THR A C    1 
ATOM   1482 C  C    B THR A 1 103 ? -26.54871 -13.59691 2.05108   0.434 29.40852 ? 1562 THR A C    1 
ATOM   1483 O  O    A THR A 1 103 ? -27.62990 -13.20244 -1.23511  0.566 12.88553 ? 1562 THR A O    1 
ATOM   1484 O  O    B THR A 1 103 ? -27.17935 -12.78994 2.73765   0.434 29.40328 ? 1562 THR A O    1 
ATOM   1485 C  CB   A THR A 1 103 ? -25.10813 -12.34003 -3.61583  0.566 29.86814 ? 1562 THR A CB   1 
ATOM   1486 C  CB   B THR A 1 103 ? -24.18992 -13.46790 1.26589   0.434 29.97947 ? 1562 THR A CB   1 
ATOM   1487 O  OG1  A THR A 1 103 ? -25.32815 -13.11548 -4.79276  0.566 30.00068 ? 1562 THR A OG1  1 
ATOM   1488 O  OG1  B THR A 1 103 ? -24.03067 -14.89674 1.27526   0.434 30.00335 ? 1562 THR A OG1  1 
ATOM   1489 C  CG2  A THR A 1 103 ? -24.19159 -13.13299 -2.67203  0.566 30.00333 ? 1562 THR A CG2  1 
ATOM   1490 C  CG2  B THR A 1 103 ? -23.82566 -12.91625 2.63132   0.434 30.00335 ? 1562 THR A CG2  1 
ATOM   1491 H  H    B THR A 1 103 ? -26.29724 -11.31719 1.30135   0.434 31.21299 ? 1562 THR A H    1 
ATOM   1492 H  HA   A THR A 1 103 ? -27.03730 -11.63835 -3.64993  0.566 15.28370 ? 1562 THR A HA   1 
ATOM   1493 H  HA   B THR A 1 103 ? -25.89751 -13.60184 0.11142   0.434 33.09547 ? 1562 THR A HA   1 
ATOM   1494 H  HB   A THR A 1 103 ? -24.66166 -11.50635 -3.83158  0.566 35.84176 ? 1562 THR A HB   1 
ATOM   1495 H  HB   B THR A 1 103 ? -23.59582 -13.07037 0.61021   0.434 35.97537 ? 1562 THR A HB   1 
ATOM   1496 H  HG1  A THR A 1 103 ? -24.59476 -13.28903 -5.16374  0.566 36.00082 ? 1562 THR A HG1  1 
ATOM   1497 H  HG1  B THR A 1 103 ? -24.21496 -15.21133 0.51851   0.434 36.00403 ? 1562 THR A HG1  1 
ATOM   1498 H  HG21 A THR A 1 103 ? -23.29776 -13.18644 -3.04500  0.566 36.00400 ? 1562 THR A HG21 1 
ATOM   1499 H  HG21 B THR A 1 103 ? -24.09868 -13.53803 3.32396   0.434 36.00402 ? 1562 THR A HG21 1 
ATOM   1500 H  HG22 A THR A 1 103 ? -24.14641 -12.69483 -1.80782  0.566 36.00400 ? 1562 THR A HG22 1 
ATOM   1501 H  HG22 B THR A 1 103 ? -22.86687 -12.78124 2.68959   0.434 36.00402 ? 1562 THR A HG22 1 
ATOM   1502 H  HG23 A THR A 1 103 ? -24.53676 -14.03149 -2.55177  0.566 36.00400 ? 1562 THR A HG23 1 
ATOM   1503 H  HG23 B THR A 1 103 ? -24.27245 -12.06756 2.77622   0.434 36.00402 ? 1562 THR A HG23 1 
ATOM   1504 N  N    A PHE A 1 104 ? -27.16496 -14.32761 -3.14040  0.566 12.36461 ? 1563 PHE A N    1 
ATOM   1505 N  N    B PHE A 1 104 ? -26.62404 -14.91914 2.21962   0.434 30.23494 ? 1563 PHE A N    1 
ATOM   1506 C  CA   A PHE A 1 104 ? -27.77170 -15.57484 -2.67836  0.566 15.89697 ? 1563 PHE A CA   1 
ATOM   1507 C  CA   B PHE A 1 104 ? -27.37074 -15.50486 3.31992   0.434 30.70858 ? 1563 PHE A CA   1 
ATOM   1508 C  C    A PHE A 1 104 ? -26.80158 -16.21329 -1.69582  0.566 17.70985 ? 1563 PHE A C    1 
ATOM   1509 C  C    B PHE A 1 104 ? -26.80526 -15.01319 4.65398   0.434 29.07954 ? 1563 PHE A C    1 
ATOM   1510 O  O    A PHE A 1 104 ? -26.05295 -17.12333 -2.00978  0.566 19.44411 ? 1563 PHE A O    1 
ATOM   1511 O  O    B PHE A 1 104 ? -25.64455 -14.59708 4.75670   0.434 28.99798 ? 1563 PHE A O    1 
ATOM   1512 C  CB   A PHE A 1 104 ? -28.04143 -16.47461 -3.88358  0.566 29.88937 ? 1563 PHE A CB   1 
ATOM   1513 C  CB   B PHE A 1 104 ? -27.27291 -17.03695 3.28936   0.434 30.00335 ? 1563 PHE A CB   1 
ATOM   1514 C  CG   A PHE A 1 104 ? -28.82320 -17.71523 -3.55714  0.566 30.00333 ? 1563 PHE A CG   1 
ATOM   1515 C  CG   B PHE A 1 104 ? -27.68401 -17.67038 1.97929   0.434 30.00335 ? 1563 PHE A CG   1 
ATOM   1516 C  CD1  A PHE A 1 104 ? -30.18962 -17.65229 -3.30637  0.566 30.00335 ? 1563 PHE A CD1  1 
ATOM   1517 C  CD1  B PHE A 1 104 ? -29.01879 -17.67121 1.57163   0.434 30.00335 ? 1563 PHE A CD1  1 
ATOM   1518 C  CD2  A PHE A 1 104 ? -28.19628 -18.94303 -3.49787  0.566 30.00334 ? 1563 PHE A CD2  1 
ATOM   1519 C  CD2  B PHE A 1 104 ? -26.74938 -18.30489 1.17504   0.434 30.00336 ? 1563 PHE A CD2  1 
ATOM   1520 C  CE1  A PHE A 1 104 ? -30.89991 -18.80155 -3.00696  0.566 30.00335 ? 1563 PHE A CE1  1 
ATOM   1521 C  CE1  B PHE A 1 104 ? -29.38934 -18.27270 0.37714   0.434 30.00336 ? 1563 PHE A CE1  1 
ATOM   1522 C  CE2  A PHE A 1 104 ? -28.90988 -20.09831 -3.20034  0.566 30.00335 ? 1563 PHE A CE2  1 
ATOM   1523 C  CE2  B PHE A 1 104 ? -27.12397 -18.90886 -0.01313  0.434 30.00335 ? 1563 PHE A CE2  1 
ATOM   1524 C  CZ   A PHE A 1 104 ? -30.25339 -20.02454 -2.95769  0.566 30.00335 ? 1563 PHE A CZ   1 
ATOM   1525 C  CZ   B PHE A 1 104 ? -28.43775 -18.89413 -0.40789  0.434 30.00336 ? 1563 PHE A CZ   1 
ATOM   1526 H  H    B PHE A 1 104 ? -26.24816 -15.49706 1.70550   0.434 36.28193 ? 1563 PHE A H    1 
ATOM   1527 H  HA   A PHE A 1 104 ? -28.60959 -15.40781 -2.21906  0.566 19.07637 ? 1563 PHE A HA   1 
ATOM   1528 H  HA   B PHE A 1 104 ? -28.30285 -15.24808 3.24159   0.434 36.85030 ? 1563 PHE A HA   1 
ATOM   1529 H  HB2  A PHE A 1 104 ? -28.54758 -15.97123 -4.54033  0.566 35.86725 ? 1563 PHE A HB2  1 
ATOM   1530 H  HB2  B PHE A 1 104 ? -26.35233 -17.29048 3.46012   0.434 36.00402 ? 1563 PHE A HB2  1 
ATOM   1531 H  HB3  A PHE A 1 104 ? -27.19193 -16.75195 -4.26087  0.566 35.86725 ? 1563 PHE A HB3  1 
ATOM   1532 H  HB3  B PHE A 1 104 ? -27.84985 -17.39650 3.98129   0.434 36.00402 ? 1563 PHE A HB3  1 
ATOM   1533 H  HD1  A PHE A 1 104 ? -30.62860 -16.83310 -3.34009  0.566 36.00402 ? 1563 PHE A HD1  1 
ATOM   1534 H  HD1  B PHE A 1 104 ? -29.66448 -17.26582 2.10422   0.434 36.00403 ? 1563 PHE A HD1  1 
ATOM   1535 H  HD2  A PHE A 1 104 ? -27.28211 -18.99852 -3.65949  0.566 36.00401 ? 1563 PHE A HD2  1 
ATOM   1536 H  HD2  B PHE A 1 104 ? -25.85749 -18.32504 1.43776   0.434 36.00403 ? 1563 PHE A HD2  1 
ATOM   1537 H  HE1  A PHE A 1 104 ? -31.81319 -18.75217 -2.83854  0.566 36.00402 ? 1563 PHE A HE1  1 
ATOM   1538 H  HE1  B PHE A 1 104 ? -30.27855 -18.25739 0.10515   0.434 36.00403 ? 1563 PHE A HE1  1 
ATOM   1539 H  HE2  A PHE A 1 104 ? -28.47449 -20.91940 -3.16643  0.566 36.00402 ? 1563 PHE A HE2  1 
ATOM   1540 H  HE2  B PHE A 1 104 ? -26.48411 -19.32511 -0.54436  0.434 36.00403 ? 1563 PHE A HE2  1 
ATOM   1541 H  HZ   A PHE A 1 104 ? -30.73303 -20.79626 -2.75948  0.566 36.00402 ? 1563 PHE A HZ   1 
ATOM   1542 H  HZ   B PHE A 1 104 ? -28.68792 -19.30296 -1.20487  0.434 36.00403 ? 1563 PHE A HZ   1 
ATOM   1543 N  N    A SER A 1 105 ? -26.75422 -15.68090 -0.47980  0.566 17.20183 ? 1564 SER A N    1 
ATOM   1544 N  N    B SER A 1 105 ? -27.62898 -15.10028 5.69567   0.434 27.53464 ? 1564 SER A N    1 
ATOM   1545 C  CA   A SER A 1 105 ? -25.92330 -16.28458 0.57558   0.566 17.44134 ? 1564 SER A CA   1 
ATOM   1546 C  CA   B SER A 1 105 ? -27.24358 -14.57891 7.00217   0.434 26.28716 ? 1564 SER A CA   1 
ATOM   1547 C  C    A SER A 1 105 ? -26.34053 -15.72637 1.93691   0.566 17.57815 ? 1564 SER A C    1 
ATOM   1548 C  C    B SER A 1 105 ? -26.00504 -15.28049 7.56350   0.434 25.06854 ? 1564 SER A C    1 
ATOM   1549 O  O    A SER A 1 105 ? -26.86475 -14.61242 2.04350   0.566 15.44641 ? 1564 SER A O    1 
ATOM   1550 O  O    B SER A 1 105 ? -25.15109 -14.63621 8.19390   0.434 24.94486 ? 1564 SER A O    1 
ATOM   1551 C  CB   A SER A 1 105 ? -24.43648 -16.03924 0.31959   0.566 18.81783 ? 1564 SER A CB   1 
ATOM   1552 C  CB   B SER A 1 105 ? -28.42063 -14.68926 7.97241   0.434 27.36615 ? 1564 SER A CB   1 
ATOM   1553 O  OG   A SER A 1 105 ? -24.03630 -15.02525 1.19338   0.566 20.62320 ? 1564 SER A OG   1 
ATOM   1554 O  OG   B SER A 1 105 ? -28.65264 -16.03948 8.33291   0.434 27.58464 ? 1564 SER A OG   1 
ATOM   1555 H  H    B SER A 1 105 ? -28.41227 -15.45459 5.67290   0.434 33.04157 ? 1564 SER A H    1 
ATOM   1556 H  HA   A SER A 1 105 ? -26.07708 -17.24210 0.59568   0.566 20.92961 ? 1564 SER A HA   1 
ATOM   1557 H  HA   B SER A 1 105 ? -27.01719 -13.64096 6.90268   0.434 31.54459 ? 1564 SER A HA   1 
ATOM   1558 H  HB2  A SER A 1 105 ? -23.93169 -16.84825 0.49733   0.566 22.58140 ? 1564 SER A HB2  1 
ATOM   1559 H  HB2  B SER A 1 105 ? -28.21913 -14.17910 8.77243   0.434 32.83938 ? 1564 SER A HB2  1 
ATOM   1560 H  HB3  A SER A 1 105 ? -24.30026 -15.75823 -0.59877  0.566 22.58140 ? 1564 SER A HB3  1 
ATOM   1561 H  HB3  B SER A 1 105 ? -29.21627 -14.33549 7.54497   0.434 32.83938 ? 1564 SER A HB3  1 
ATOM   1562 H  HG   A SER A 1 105 ? -23.22598 -14.84213 1.06911   0.566 24.74784 ? 1564 SER A HG   1 
ATOM   1563 H  HG   B SER A 1 105 ? -29.30230 -16.08769 8.86321   0.434 33.10156 ? 1564 SER A HG   1 
ATOM   1564 N  N    A GLU A 1 106 ? -26.15676 -16.54855 2.97741   0.566 18.93104 ? 1565 GLU A N    1 
ATOM   1565 N  N    B GLU A 1 106 ? -25.86425 -16.59636 7.33208   0.434 23.54212 ? 1565 GLU A N    1 
ATOM   1566 C  CA   A GLU A 1 106 ? -26.38402 -16.10815 4.34776   0.566 21.10253 ? 1565 GLU A CA   1 
ATOM   1567 C  CA   B GLU A 1 106 ? -24.75869 -17.32407 7.94126   0.434 22.25266 ? 1565 GLU A CA   1 
ATOM   1568 C  C    A GLU A 1 106 ? -25.08490 -15.69340 5.05500   0.566 20.43904 ? 1565 GLU A C    1 
ATOM   1569 C  C    B GLU A 1 106 ? -23.39687 -16.90853 7.38381   0.434 18.47315 ? 1565 GLU A C    1 
ATOM   1570 O  O    A GLU A 1 106 ? -25.10249 -15.44315 6.26827   0.566 20.45742 ? 1565 GLU A O    1 
ATOM   1571 O  O    B GLU A 1 106 ? -22.37845 -17.09822 8.06046   0.434 18.08089 ? 1565 GLU A O    1 
ATOM   1572 C  CB   A GLU A 1 106 ? -27.08088 -17.20846 5.13922   0.566 29.93972 ? 1565 GLU A CB   1 
ATOM   1573 C  CB   B GLU A 1 106 ? -24.94264 -18.83505 7.75457   0.434 29.93973 ? 1565 GLU A CB   1 
ATOM   1574 C  CG   A GLU A 1 106 ? -28.48209 -17.55396 4.60774   0.566 30.00335 ? 1565 GLU A CG   1 
ATOM   1575 C  CG   B GLU A 1 106 ? -26.05539 -19.43926 8.58319   0.434 30.00072 ? 1565 GLU A CG   1 
ATOM   1576 C  CD   A GLU A 1 106 ? -29.58529 -16.90209 5.41958   0.566 30.00336 ? 1565 GLU A CD   1 
ATOM   1577 C  CD   B GLU A 1 106 ? -27.25064 -19.80102 7.74899   0.434 30.00336 ? 1565 GLU A CD   1 
ATOM   1578 O  OE1  A GLU A 1 106 ? -29.86045 -15.70349 5.21873   0.566 30.00599 ? 1565 GLU A OE1  1 
ATOM   1579 O  OE1  B GLU A 1 106 ? -27.95410 -18.87688 7.30101   0.434 30.00336 ? 1565 GLU A OE1  1 
ATOM   1580 O  OE2  A GLU A 1 106 ? -30.19334 -17.59930 6.26963   0.566 30.00336 ? 1565 GLU A OE2  1 
ATOM   1581 O  OE2  B GLU A 1 106 ? -27.48497 -21.01515 7.52939   0.434 30.00862 ? 1565 GLU A OE2  1 
ATOM   1582 H  H    A GLU A 1 106 ? -25.90015 -17.36647 2.90846   0.566 22.71725 ? 1565 GLU A H    1 
ATOM   1583 H  H    B GLU A 1 106 ? -26.38483 -17.07096 6.83878   0.434 28.25054 ? 1565 GLU A H    1 
ATOM   1584 H  HA   A GLU A 1 106 ? -26.97036 -15.33559 4.33164   0.566 25.32303 ? 1565 GLU A HA   1 
ATOM   1585 H  HA   B GLU A 1 106 ? -24.76577 -17.13221 8.89207   0.434 26.70319 ? 1565 GLU A HA   1 
ATOM   1586 H  HB2  A GLU A 1 106 ? -26.54080 -18.01314 5.09809   0.566 35.92767 ? 1565 GLU A HB2  1 
ATOM   1587 H  HB2  B GLU A 1 106 ? -25.14461 -19.00868 6.82185   0.434 35.92768 ? 1565 GLU A HB2  1 
ATOM   1588 H  HB3  A GLU A 1 106 ? -27.17549 -16.91911 6.06021   0.566 35.92767 ? 1565 GLU A HB3  1 
ATOM   1589 H  HB3  B GLU A 1 106 ? -24.11736 -19.27976 8.00367   0.434 35.92768 ? 1565 GLU A HB3  1 
ATOM   1590 H  HG2  A GLU A 1 106 ? -28.55921 -17.24489 3.69154   0.566 36.00402 ? 1565 GLU A HG2  1 
ATOM   1591 H  HG2  B GLU A 1 106 ? -25.73061 -20.24627 9.01230   0.434 36.00086 ? 1565 GLU A HG2  1 
ATOM   1592 H  HG3  A GLU A 1 106 ? -28.60781 -18.51504 4.64535   0.566 36.00402 ? 1565 GLU A HG3  1 
ATOM   1593 H  HG3  B GLU A 1 106 ? -26.33753 -18.79755 9.25364   0.434 36.00086 ? 1565 GLU A HG3  1 
ATOM   1594 N  N    A LEU A 1 107 ? -23.97132 -15.59352 4.32046   0.566 18.37040 ? 1566 LEU A N    1 
ATOM   1595 N  N    B LEU A 1 107 ? -23.35703 -16.34952 6.17628   0.434 17.75986 ? 1566 LEU A N    1 
ATOM   1596 C  CA   A LEU A 1 107 ? -22.60736 -15.51037 4.87992   0.566 17.14667 ? 1566 LEU A CA   1 
ATOM   1597 C  CA   B LEU A 1 107 ? -22.11291 -15.90898 5.55775   0.434 18.71776 ? 1566 LEU A CA   1 
ATOM   1598 C  C    A LEU A 1 107 ? -22.13387 -14.06133 5.01068   0.566 17.80199 ? 1566 LEU A C    1 
ATOM   1599 C  C    B LEU A 1 107 ? -21.94503 -14.39234 5.60825   0.434 17.82551 ? 1566 LEU A C    1 
ATOM   1600 O  O    A LEU A 1 107 ? -21.03397 -13.68463 4.64471   0.566 16.24651 ? 1566 LEU A O    1 
ATOM   1601 O  O    B LEU A 1 107 ? -20.91736 -13.86970 5.17649   0.434 14.07262 ? 1566 LEU A O    1 
ATOM   1602 C  CB   A LEU A 1 107 ? -21.67614 -16.36334 4.04190   0.566 18.10725 ? 1566 LEU A CB   1 
ATOM   1603 C  CB   B LEU A 1 107 ? -22.06015 -16.39057 4.10481   0.434 19.33896 ? 1566 LEU A CB   1 
ATOM   1604 C  CG   A LEU A 1 107 ? -21.99782 -17.87432 3.94959   0.566 19.57846 ? 1566 LEU A CG   1 
ATOM   1605 C  CG   B LEU A 1 107 ? -21.93558 -17.90332 3.84127   0.434 21.29181 ? 1566 LEU A CG   1 
ATOM   1606 C  CD1  A LEU A 1 107 ? -22.69038 -18.18423 2.64770   0.566 21.58384 ? 1566 LEU A CD1  1 
ATOM   1607 C  CD1  B LEU A 1 107 ? -20.46544 -18.30322 3.89498   0.434 22.09449 ? 1566 LEU A CD1  1 
ATOM   1608 C  CD2  A LEU A 1 107 ? -20.69072 -18.60189 3.96278   0.566 19.91268 ? 1566 LEU A CD2  1 
ATOM   1609 C  CD2  B LEU A 1 107 ? -22.72629 -18.72905 4.78522   0.434 23.00507 ? 1566 LEU A CD2  1 
ATOM   1610 H  H    A LEU A 1 107 ? -23.97500 -15.57069 3.46077   0.566 22.04449 ? 1566 LEU A H    1 
ATOM   1611 H  H    B LEU A 1 107 ? -24.05159 -16.21297 5.68787   0.434 21.31183 ? 1566 LEU A H    1 
ATOM   1612 H  HA   A LEU A 1 107 ? -22.61134 -15.86459 5.78292   0.566 20.57600 ? 1566 LEU A HA   1 
ATOM   1613 H  HA   B LEU A 1 107 ? -21.36354 -16.30591 6.02870   0.434 22.46131 ? 1566 LEU A HA   1 
ATOM   1614 H  HB2  A LEU A 1 107 ? -21.68760 -16.01606 3.13627   0.566 21.72870 ? 1566 LEU A HB2  1 
ATOM   1615 H  HB2  B LEU A 1 107 ? -22.87665 -16.09958 3.66945   0.434 23.20675 ? 1566 LEU A HB2  1 
ATOM   1616 H  HB3  A LEU A 1 107 ? -20.78424 -16.28654 4.41541   0.566 21.72870 ? 1566 LEU A HB3  1 
ATOM   1617 H  HB3  B LEU A 1 107 ? -21.29272 -15.97179 3.68461   0.434 23.20675 ? 1566 LEU A HB3  1 
ATOM   1618 H  HG   A LEU A 1 107 ? -22.57295 -18.14550 4.68211   0.566 23.49415 ? 1566 LEU A HG   1 
ATOM   1619 H  HG   B LEU A 1 107 ? -22.29983 -18.08336 2.96047   0.434 25.55017 ? 1566 LEU A HG   1 
ATOM   1620 H  HD11 A LEU A 1 107 ? -22.88911 -19.13305 2.61376   0.566 25.90061 ? 1566 LEU A HD11 1 
ATOM   1621 H  HD11 B LEU A 1 107 ? -20.39324 -19.26043 3.75551   0.434 26.51338 ? 1566 LEU A HD11 1 
ATOM   1622 H  HD12 A LEU A 1 107 ? -23.51262 -17.67206 2.59766   0.566 25.90061 ? 1566 LEU A HD12 1 
ATOM   1623 H  HD12 B LEU A 1 107 ? -19.98384 -17.83021 3.19840   0.434 26.51338 ? 1566 LEU A HD12 1 
ATOM   1624 H  HD13 A LEU A 1 107 ? -22.10484 -17.94243 1.91314   0.566 25.90061 ? 1566 LEU A HD13 1 
ATOM   1625 H  HD13 B LEU A 1 107 ? -20.10562 -18.06756 4.76440   0.434 26.51338 ? 1566 LEU A HD13 1 
ATOM   1626 H  HD21 A LEU A 1 107 ? -20.85498 -19.54872 3.83070   0.566 23.89521 ? 1566 LEU A HD21 1 
ATOM   1627 H  HD21 B LEU A 1 107 ? -22.70936 -19.65220 4.48788   0.434 27.60608 ? 1566 LEU A HD21 1 
ATOM   1628 H  HD22 A LEU A 1 107 ? -20.13185 -18.26018 3.24738   0.566 23.89521 ? 1566 LEU A HD22 1 
ATOM   1629 H  HD22 B LEU A 1 107 ? -22.33497 -18.65931 5.67004   0.434 27.60608 ? 1566 LEU A HD22 1 
ATOM   1630 H  HD23 A LEU A 1 107 ? -20.25757 -18.45754 4.81860   0.566 23.89521 ? 1566 LEU A HD23 1 
ATOM   1631 H  HD23 B LEU A 1 107 ? -23.63983 -18.40331 4.80095   0.434 27.60608 ? 1566 LEU A HD23 1 
ATOM   1632 N  N    A ARG A 1 108 ? -22.92832 -13.26767 5.72489   0.566 22.56819 ? 1567 ARG A N    1 
ATOM   1633 N  N    B ARG A 1 108 ? -22.89926 -13.68468 6.18228   0.434 18.02560 ? 1567 ARG A N    1 
ATOM   1634 C  CA   A ARG A 1 108 ? -22.81911 -11.80323 5.71303   0.566 25.06586 ? 1567 ARG A CA   1 
ATOM   1635 C  CA   B ARG A 1 108 ? -22.83055 -12.22434 6.19996   0.434 17.98873 ? 1567 ARG A CA   1 
ATOM   1636 C  C    A ARG A 1 108 ? -21.46600 -11.12537 5.91044   0.566 25.10271 ? 1567 ARG A C    1 
ATOM   1637 C  C    B ARG A 1 108 ? -21.73921 -11.76595 7.13546   0.434 16.20183 ? 1567 ARG A C    1 
ATOM   1638 O  O    A ARG A 1 108 ? -20.88092 -10.54838 4.97136   0.566 24.84483 ? 1567 ARG A O    1 
ATOM   1639 O  O    B ARG A 1 108 ? -21.58927 -12.29405 8.23444   0.434 16.83861 ? 1567 ARG A O    1 
ATOM   1640 C  CB   A ARG A 1 108 ? -23.80948 -11.23187 6.74922   0.566 25.93964 ? 1567 ARG A CB   1 
ATOM   1641 C  CB   B ARG A 1 108 ? -24.18770 -11.69294 6.64478   0.434 19.05198 ? 1567 ARG A CB   1 
ATOM   1642 H  H    A ARG A 1 108 ? -23.55524 -13.55565 6.23834   0.566 27.08183 ? 1567 ARG A H    1 
ATOM   1643 H  H    B ARG A 1 108 ? -23.59345 -14.01604 6.56685   0.434 21.63072 ? 1567 ARG A H    1 
ATOM   1644 H  HA   A ARG A 1 108 ? -23.01589 -11.57900 4.79004   0.566 30.07904 ? 1567 ARG A HA   1 
ATOM   1645 H  HA   B ARG A 1 108 ? -22.62157 -11.87391 5.31995   0.434 21.58648 ? 1567 ARG A HA   1 
ATOM   1646 N  N    A LEU A 1 109 ? -20.96143 -11.13200 7.13961   0.566 23.83413 ? 1568 LEU A N    1 
ATOM   1647 N  N    B LEU A 1 109 ? -20.88279 -10.82737 6.66242   0.434 18.54932 ? 1568 LEU A N    1 
ATOM   1648 C  CA   A LEU A 1 109 ? -19.87803 -10.25552 7.58475   0.566 21.91294 ? 1568 LEU A CA   1 
ATOM   1649 C  CA   B LEU A 1 109 ? -19.88143 -10.17812 7.49147   0.434 20.00480 ? 1568 LEU A CA   1 
ATOM   1650 C  C    A LEU A 1 109 ? -20.39645 -8.81162  7.73050   0.566 23.11572 ? 1568 LEU A C    1 
ATOM   1651 C  C    B LEU A 1 109 ? -20.35071 -8.73694  7.70976   0.434 22.42879 ? 1568 LEU A C    1 
ATOM   1652 O  O    A LEU A 1 109 ? -20.72424 -8.15936  6.74518   0.566 25.03958 ? 1568 LEU A O    1 
ATOM   1653 O  O    B LEU A 1 109 ? -20.59930 -8.01581  6.74821   0.434 24.72898 ? 1568 LEU A O    1 
ATOM   1654 C  CB   A LEU A 1 109 ? -18.60724 -10.30357 6.69819   0.566 19.24159 ? 1568 LEU A CB   1 
ATOM   1655 C  CB   B LEU A 1 109 ? -18.47652 -10.20131 6.85902   0.434 18.43361 ? 1568 LEU A CB   1 
ATOM   1656 C  CG   A LEU A 1 109 ? -18.02127 -11.67579 6.36436   0.566 17.34927 ? 1568 LEU A CG   1 
ATOM   1657 C  CG   B LEU A 1 109 ? -17.94765 -11.57160 6.43717   0.434 18.14668 ? 1568 LEU A CG   1 
ATOM   1658 C  CD1  A LEU A 1 109 ? -16.53360 -11.51017 5.94061   0.566 17.05709 ? 1568 LEU A CD1  1 
ATOM   1659 C  CD1  B LEU A 1 109 ? -16.47095 -11.44918 5.99681   0.434 18.14141 ? 1568 LEU A CD1  1 
ATOM   1660 C  CD2  A LEU A 1 109 ? -18.14353 -12.65140 7.52089   0.566 18.03874 ? 1568 LEU A CD2  1 
ATOM   1661 C  CD2  B LEU A 1 109 ? -18.08708 -12.58367 7.55911   0.434 18.95725 ? 1568 LEU A CD2  1 
ATOM   1662 H  H    B LEU A 1 109 ? -20.87637 -10.55681 5.84611   0.434 22.25919 ? 1568 LEU A H    1 
ATOM   1663 H  HA   A LEU A 1 109 ? -19.58165 -10.58586 8.44726   0.566 26.29553 ? 1568 LEU A HA   1 
ATOM   1664 H  HA   B LEU A 1 109 ? -19.80982 -10.64367 8.33943   0.434 24.00576 ? 1568 LEU A HA   1 
ATOM   1665 H  HB2  A LEU A 1 109 ? -18.82064 -9.87794  5.85309   0.566 23.08991 ? 1568 LEU A HB2  1 
ATOM   1666 H  HB2  B LEU A 1 109 ? -18.49427 -9.64462  6.06487   0.434 22.12033 ? 1568 LEU A HB2  1 
ATOM   1667 H  HB3  A LEU A 1 109 ? -17.91049 -9.80571  7.15379   0.566 23.08991 ? 1568 LEU A HB3  1 
ATOM   1668 H  HB3  B LEU A 1 109 ? -17.84949 -9.83888  7.50428   0.434 22.12033 ? 1568 LEU A HB3  1 
ATOM   1669 H  HG   A LEU A 1 109 ? -18.52647 -12.05875 5.63019   0.566 20.81912 ? 1568 LEU A HG   1 
ATOM   1670 H  HG   B LEU A 1 109 ? -18.47213 -11.89623 5.68855   0.434 21.77602 ? 1568 LEU A HG   1 
ATOM   1671 H  HD11 A LEU A 1 109 ? -16.16998 -12.38127 5.71731   0.566 20.46851 ? 1568 LEU A HD11 1 
ATOM   1672 H  HD11 B LEU A 1 109 ? -16.14686 -12.32419 5.73180   0.434 21.76969 ? 1568 LEU A HD11 1 
ATOM   1673 H  HD12 A LEU A 1 109 ? -16.48849 -10.92502 5.16830   0.566 20.46851 ? 1568 LEU A HD12 1 
ATOM   1674 H  HD12 B LEU A 1 109 ? -16.41452 -10.83489 5.24824   0.434 21.76969 ? 1568 LEU A HD12 1 
ATOM   1675 H  HD13 A LEU A 1 109 ? -16.03634 -11.12334 6.67818   0.566 20.46851 ? 1568 LEU A HD13 1 
ATOM   1676 H  HD13 B LEU A 1 109 ? -15.94643 -11.11345 6.74049   0.434 21.76969 ? 1568 LEU A HD13 1 
ATOM   1677 H  HD21 A LEU A 1 109 ? -17.63395 -13.45068 7.31502   0.566 21.64649 ? 1568 LEU A HD21 1 
ATOM   1678 H  HD21 B LEU A 1 109 ? -17.63614 -13.40335 7.30285   0.434 22.74870 ? 1568 LEU A HD21 1 
ATOM   1679 H  HD22 A LEU A 1 109 ? -17.79452 -12.23435 8.32411   0.566 21.64649 ? 1568 LEU A HD22 1 
ATOM   1680 H  HD22 B LEU A 1 109 ? -17.68320 -12.22141 8.36319   0.434 22.74870 ? 1568 LEU A HD22 1 
ATOM   1681 H  HD23 A LEU A 1 109 ? -19.07842 -12.87808 7.64535   0.566 21.64649 ? 1568 LEU A HD23 1 
ATOM   1682 H  HD23 B LEU A 1 109 ? -19.02897 -12.75814 7.71178   0.434 22.74870 ? 1568 LEU A HD23 1 
ATOM   1683 N  N    . ASP A 1 110 ? -20.47022 -8.34115  8.95510   1.000 24.40005 ? 1569 ASP A N    1 
ATOM   1684 C  CA   . ASP A 1 110 ? -21.08409 -7.07193  9.29150   1.000 26.53712 ? 1569 ASP A CA   1 
ATOM   1685 C  C    . ASP A 1 110 ? -20.07570 -5.96131  9.35681   1.000 24.44220 ? 1569 ASP A C    1 
ATOM   1686 O  O    . ASP A 1 110 ? -20.47141 -4.78853  9.43372   1.000 26.51340 ? 1569 ASP A O    1 
ATOM   1687 C  CB   . ASP A 1 110 ? -21.78001 -7.20180  10.65944  1.000 30.16891 ? 1569 ASP A CB   1 
ATOM   1688 H  H    . ASP A 1 110 ? -20.15926 -8.75375  9.64260   1.000 29.28006 ? 1569 ASP A H    1 
ATOM   1689 H  HA   . ASP A 1 110 ? -21.75097 -6.83852  8.62690   1.000 31.84455 ? 1569 ASP A HA   1 
ATOM   1690 N  N    . SER A 1 111 ? -18.78223 -6.28010  9.31103   1.000 20.04433 ? 1570 SER A N    1 
ATOM   1691 C  CA   . SER A 1 111 ? -17.78204 -5.26363  9.56916   1.000 16.50972 ? 1570 SER A CA   1 
ATOM   1692 C  C    . SER A 1 111 ? -16.52619 -5.58786  8.78074   1.000 13.94619 ? 1570 SER A C    1 
ATOM   1693 O  O    . SER A 1 111 ? -16.10988 -6.76488  8.72599   1.000 13.71459 ? 1570 SER A O    1 
ATOM   1694 C  CB   . SER A 1 111 ? -17.44537 -5.23392  11.05874  1.000 17.37549 ? 1570 SER A CB   1 
ATOM   1695 O  OG   . SER A 1 111 ? -16.29059 -4.47009  11.26695  1.000 17.05177 ? 1570 SER A OG   1 
ATOM   1696 H  H    . SER A 1 111 ? -18.47226 -7.06294  9.13588   1.000 24.05319 ? 1570 SER A H    1 
ATOM   1697 H  HA   . SER A 1 111 ? -18.10695 -4.39544  9.28353   1.000 19.81167 ? 1570 SER A HA   1 
ATOM   1698 H  HB2  . SER A 1 111 ? -18.18410 -4.83693  11.54616  1.000 20.85058 ? 1570 SER A HB2  1 
ATOM   1699 H  HB3  . SER A 1 111 ? -17.29084 -6.13945  11.37024  1.000 20.85058 ? 1570 SER A HB3  1 
ATOM   1700 H  HG   . SER A 1 111 ? -16.09800 -4.45749  12.08448  1.000 20.46213 ? 1570 SER A HG   1 
ATOM   1701 N  N    . VAL A 1 112 ? -15.85458 -4.54487  8.28153   1.000 12.88553 ? 1571 VAL A N    1 
ATOM   1702 C  CA   A VAL A 1 112 ? -14.55393 -4.75033  7.64339   0.609 12.44074 ? 1571 VAL A CA   1 
ATOM   1703 C  CA   B VAL A 1 112 ? -14.54861 -4.73845  7.64851   0.391 12.56969 ? 1571 VAL A CA   1 
ATOM   1704 C  C    . VAL A 1 112 ? -13.55426 -5.34367  8.62242   1.000 11.50919 ? 1571 VAL A C    1 
ATOM   1705 O  O    . VAL A 1 112 ? -12.60173 -6.00544  8.20091   1.000 12.66439 ? 1571 VAL A O    1 
ATOM   1706 C  CB   A VAL A 1 112 ? -14.04805 -3.38707  7.10562   0.609 13.84614 ? 1571 VAL A CB   1 
ATOM   1707 C  CB   B VAL A 1 112 ? -13.99352 -3.40443  7.08794   0.391 13.86984 ? 1571 VAL A CB   1 
ATOM   1708 C  CG1  A VAL A 1 112 ? -12.63578 -3.55910  6.56079   0.609 12.93554 ? 1571 VAL A CG1  1 
ATOM   1709 C  CG1  B VAL A 1 112 ? -14.75511 -2.99120  5.84182   0.391 14.09352 ? 1571 VAL A CG1  1 
ATOM   1710 C  CG2  A VAL A 1 112 ? -14.96249 -2.87715  6.00840   0.609 14.96726 ? 1571 VAL A CG2  1 
ATOM   1711 C  CG2  B VAL A 1 112 ? -13.96696 -2.31623  8.14697   0.391 14.31460 ? 1571 VAL A CG2  1 
ATOM   1712 H  H    A VAL A 1 112 ? -16.12476 -3.72862  8.29984   0.609 15.46264 ? 1571 VAL A H    1 
ATOM   1713 H  H    B VAL A 1 112 ? -16.12855 -3.72981  8.29660   0.391 15.46264 ? 1571 VAL A H    1 
ATOM   1714 H  HA   A VAL A 1 112 ? -14.64715 -5.37039  6.90330   0.609 14.92889 ? 1571 VAL A HA   1 
ATOM   1715 H  HA   B VAL A 1 112 ? -14.68063 -5.35178  6.90872   0.391 15.08363 ? 1571 VAL A HA   1 
ATOM   1716 H  HB   A VAL A 1 112 ? -14.04366 -2.73636  7.82497   0.609 16.61537 ? 1571 VAL A HB   1 
ATOM   1717 H  HB   B VAL A 1 112 ? -13.06947 -3.53805  6.82494   0.391 16.64381 ? 1571 VAL A HB   1 
ATOM   1718 H  HG11 A VAL A 1 112 ? -12.42215 -2.80252  5.99259   0.609 15.52265 ? 1571 VAL A HG11 1 
ATOM   1719 H  HG11 B VAL A 1 112 ? -14.37312 -2.16926  5.49628   0.391 16.91223 ? 1571 VAL A HG11 1 
ATOM   1720 H  HG12 A VAL A 1 112 ? -12.01357 -3.60089  7.30377   0.609 15.52265 ? 1571 VAL A HG12 1 
ATOM   1721 H  HG12 B VAL A 1 112 ? -14.68086 -3.69497  5.17841   0.391 16.91223 ? 1571 VAL A HG12 1 
ATOM   1722 H  HG13 A VAL A 1 112 ? -12.59335 -4.38088  6.04719   0.609 15.52265 ? 1571 VAL A HG13 1 
ATOM   1723 H  HG13 B VAL A 1 112 ? -15.68676 -2.85144  6.07291   0.391 16.91223 ? 1571 VAL A HG13 1 
ATOM   1724 H  HG21 A VAL A 1 112 ? -14.58775 -2.06270  5.63809   0.609 17.96071 ? 1571 VAL A HG21 1 
ATOM   1725 H  HG21 B VAL A 1 112 ? -13.29006 -1.66266  7.91129   0.391 17.17753 ? 1571 VAL A HG21 1 
ATOM   1726 H  HG22 A VAL A 1 112 ? -15.03301 -3.55327  5.31645   0.609 17.96071 ? 1571 VAL A HG22 1 
ATOM   1727 H  HG22 B VAL A 1 112 ? -14.83807 -1.89124  8.18499   0.391 17.17753 ? 1571 VAL A HG22 1 
ATOM   1728 H  HG23 A VAL A 1 112 ? -15.83794 -2.69696  6.38524   0.609 17.96071 ? 1571 VAL A HG23 1 
ATOM   1729 H  HG23 B VAL A 1 112 ? -13.75618 -2.71595  9.00528   0.391 17.17753 ? 1571 VAL A HG23 1 
ATOM   1730 N  N    . VAL A 1 113 ? -13.75387 -5.17748  9.93019   1.000 12.06966 ? 1572 VAL A N    1 
ATOM   1731 C  CA   . VAL A 1 113 ? -12.85540 -5.81589  10.90125  1.000 12.48554 ? 1572 VAL A CA   1 
ATOM   1732 C  C    . VAL A 1 113 ? -12.92462 -7.33678  10.77995  1.000 13.13022 ? 1572 VAL A C    1 
ATOM   1733 O  O    . VAL A 1 113 ? -11.92207 -8.02332  10.93034  1.000 12.63288 ? 1572 VAL A O    1 
ATOM   1734 C  CB   . VAL A 1 113 ? -13.15624 -5.33043  12.31727  1.000 14.76470 ? 1572 VAL A CB   1 
ATOM   1735 C  CG1  . VAL A 1 113 ? -12.28800 -6.04100  13.34205  1.000 17.69908 ? 1572 VAL A CG1  1 
ATOM   1736 C  CG2  . VAL A 1 113 ? -12.91567 -3.79295  12.41610  1.000 15.30424 ? 1572 VAL A CG2  1 
ATOM   1737 H  H    . VAL A 1 113 ? -14.38731 -4.71089  10.27753  1.000 14.48359 ? 1572 VAL A H    1 
ATOM   1738 H  HA   . VAL A 1 113 ? -11.94542 -5.55047  10.69534  1.000 14.98264 ? 1572 VAL A HA   1 
ATOM   1739 H  HB   . VAL A 1 113 ? -14.08491 -5.52967  12.51419  1.000 17.71764 ? 1572 VAL A HB   1 
ATOM   1740 H  HG11 . VAL A 1 113 ? -12.35970 -5.57856  14.19170  1.000 21.23889 ? 1572 VAL A HG11 1 
ATOM   1741 H  HG12 . VAL A 1 113 ? -12.59566 -6.95605  13.43649  1.000 21.23889 ? 1572 VAL A HG12 1 
ATOM   1742 H  HG13 . VAL A 1 113 ? -11.36730 -6.03141  13.03690  1.000 21.23889 ? 1572 VAL A HG13 1 
ATOM   1743 H  HG21 . VAL A 1 113 ? -13.08877 -3.50405  13.32576  1.000 18.36509 ? 1572 VAL A HG21 1 
ATOM   1744 H  HG22 . VAL A 1 113 ? -11.99515 -3.60136  12.17771  1.000 18.36509 ? 1572 VAL A HG22 1 
ATOM   1745 H  HG23 . VAL A 1 113 ? -13.51694 -3.33929  11.80489  1.000 18.36509 ? 1572 VAL A HG23 1 
ATOM   1746 N  N    . GLN A 1 114 ? -14.10529 -7.86357  10.48197  1.000 11.99074 ? 1573 GLN A N    1 
ATOM   1747 C  CA   . GLN A 1 114 ? -14.22590 -9.29463  10.27271  1.000 12.56969 ? 1573 GLN A CA   1 
ATOM   1748 C  C    . GLN A 1 114 ? -13.46779 -9.74473  9.01914   1.000 11.19592 ? 1573 GLN A C    1 
ATOM   1749 O  O    . GLN A 1 114 ? -12.92115 -10.86279 8.98856   1.000 12.00119 ? 1573 GLN A O    1 
ATOM   1750 C  CB   . GLN A 1 114 ? -15.69303 -9.69839  10.13732  1.000 13.93841 ? 1573 GLN A CB   1 
ATOM   1751 C  CG   . GLN A 1 114 ? -16.44375 -9.61286  11.39193  1.000 19.25996 ? 1573 GLN A CG   1 
ATOM   1752 C  CD   . GLN A 1 114 ? -17.97290 -9.64689  11.15461  1.000 23.62101 ? 1573 GLN A CD   1 
ATOM   1753 O  OE1  . GLN A 1 114 ? -18.47238 -9.15301  10.11946  1.000 25.03163 ? 1573 GLN A OE1  1 
ATOM   1754 N  NE2  . GLN A 1 114 ? -18.68895 -10.17855 12.09484  1.000 28.08715 ? 1573 GLN A NE2  1 
ATOM   1755 H  H    . GLN A 1 114 ? -14.83792 -7.42127  10.39695  1.000 14.38889 ? 1573 GLN A H    1 
ATOM   1756 H  HA   . GLN A 1 114 ? -13.84978 -9.73786  11.04922  1.000 15.08363 ? 1573 GLN A HA   1 
ATOM   1757 H  HB2  . GLN A 1 114 ? -16.12068 -9.11058  9.49505   1.000 16.72610 ? 1573 GLN A HB2  1 
ATOM   1758 H  HB3  . GLN A 1 114 ? -15.73691 -10.61648 9.82734   1.000 16.72610 ? 1573 GLN A HB3  1 
ATOM   1759 H  HG2  . GLN A 1 114 ? -16.20766 -10.36503 11.95709  1.000 23.11196 ? 1573 GLN A HG2  1 
ATOM   1760 H  HG3  . GLN A 1 114 ? -16.22459 -8.78036  11.83893  1.000 23.11196 ? 1573 GLN A HG3  1 
ATOM   1761 H  HE21 . GLN A 1 114 ? -18.30924 -10.48795 12.80173  1.000 33.70458 ? 1573 GLN A HE21 1 
ATOM   1762 H  HE22 . GLN A 1 114 ? -19.54384 -10.22198 12.01191  1.000 33.70458 ? 1573 GLN A HE22 1 
ATOM   1763 N  N    . TRP A 1 115 ? -13.45687 -8.91794  7.97336   1.000 10.91154 ? 1574 TRP A N    1 
ATOM   1764 C  CA   . TRP A 1 115 ? -12.63990 -9.20216  6.79740   1.000 10.42478 ? 1574 TRP A CA   1 
ATOM   1765 C  C    . TRP A 1 115 ? -11.16895 -9.27286  7.18044   1.000 11.07474 ? 1574 TRP A C    1 
ATOM   1766 O  O    . TRP A 1 115 ? -10.44812 -10.18498 6.80387   1.000 11.66954 ? 1574 TRP A O    1 
ATOM   1767 C  CB   . TRP A 1 115 ? -12.77475 -8.20402  5.66792   1.000 10.71414 ? 1574 TRP A CB   1 
ATOM   1768 C  CG   . TRP A 1 115 ? -14.19165 -7.71021  5.30622   1.000 9.82995  ? 1574 TRP A CG   1 
ATOM   1769 C  CD1  . TRP A 1 115 ? -15.39602 -7.96115  5.88151   1.000 11.59322 ? 1574 TRP A CD1  1 
ATOM   1770 C  CD2  . TRP A 1 115 ? -14.40344 -6.72858  4.27279   1.000 9.43778  ? 1574 TRP A CD2  1 
ATOM   1771 N  NE1  . TRP A 1 115 ? -16.34098 -7.18684  5.25403   1.000 11.54315 ? 1574 TRP A NE1  1 
ATOM   1772 C  CE2  . TRP A 1 115 ? -15.76787 -6.42129  4.27204   1.000 10.14580 ? 1574 TRP A CE2  1 
ATOM   1773 C  CE3  . TRP A 1 115 ? -13.57082 -6.08217  3.36713   1.000 10.32205 ? 1574 TRP A CE3  1 
ATOM   1774 C  CZ2  . TRP A 1 115 ? -16.31019 -5.51335  3.39731   1.000 10.90893 ? 1574 TRP A CZ2  1 
ATOM   1775 C  CZ3  . TRP A 1 115 ? -14.09781 -5.16731  2.50013   1.000 10.94580 ? 1574 TRP A CZ3  1 
ATOM   1776 C  CH2  . TRP A 1 115 ? -15.47584 -4.87471  2.53008   1.000 11.32213 ? 1574 TRP A CH2  1 
ATOM   1777 H  H    . TRP A 1 115 ? -13.91128 -8.18971  7.92038   1.000 13.09385 ? 1574 TRP A H    1 
ATOM   1778 H  HA   . TRP A 1 115 ? -12.97664 -10.04641 6.45866   1.000 12.50974 ? 1574 TRP A HA   1 
ATOM   1779 H  HB2  . TRP A 1 115 ? -12.25821 -7.41786  5.90464   1.000 12.85697 ? 1574 TRP A HB2  1 
ATOM   1780 H  HB3  . TRP A 1 115 ? -12.40963 -8.61217  4.86729   1.000 12.85697 ? 1574 TRP A HB3  1 
ATOM   1781 H  HD1  . TRP A 1 115 ? -15.55365 -8.55482  6.57980   1.000 13.91186 ? 1574 TRP A HD1  1 
ATOM   1782 H  HE1  . TRP A 1 115 ? -17.17823 -7.18284  5.45047   1.000 13.85178 ? 1574 TRP A HE1  1 
ATOM   1783 H  HE3  . TRP A 1 115 ? -12.66038 -6.27124  3.35137   1.000 12.38645 ? 1574 TRP A HE3  1 
ATOM   1784 H  HZ2  . TRP A 1 115 ? -17.22362 -5.33859  3.39658   1.000 13.09072 ? 1574 TRP A HZ2  1 
ATOM   1785 H  HZ3  . TRP A 1 115 ? -13.54548 -4.73644  1.88843   1.000 13.13497 ? 1574 TRP A HZ3  1 
ATOM   1786 H  HH2  . TRP A 1 115 ? -15.82105 -4.23590  1.94901   1.000 13.58656 ? 1574 TRP A HH2  1 
ATOM   1787 N  N    . MET A 1 116 ? -10.72519 -8.27438  7.94008   1.000 11.07748 ? 1575 MET A N    1 
ATOM   1788 C  CA   A MET A 1 116 ? -9.33782  -8.24740  8.38930   0.534 12.41172 ? 1575 MET A CA   1 
ATOM   1789 C  CA   B MET A 1 116 ? -9.34326  -8.22747  8.41856   0.466 11.15894 ? 1575 MET A CA   1 
ATOM   1790 C  C    . MET A 1 116 ? -9.00244  -9.49733  9.19143   1.000 11.48541 ? 1575 MET A C    1 
ATOM   1791 O  O    . MET A 1 116 ? -7.93367  -10.10217 8.99682   1.000 12.41437 ? 1575 MET A O    1 
ATOM   1792 C  CB   A MET A 1 116 ? -9.05159  -7.00432  9.21499   0.534 13.81727 ? 1575 MET A CB   1 
ATOM   1793 C  CB   B MET A 1 116 ? -9.11648  -7.01383  9.32168   0.466 10.16946 ? 1575 MET A CB   1 
ATOM   1794 C  CG   A MET A 1 116 ? -8.88111  -5.77004  8.36724   0.534 17.30442 ? 1575 MET A CG   1 
ATOM   1795 C  CG   B MET A 1 116 ? -9.16296  -5.66291  8.61441   0.466 10.78267 ? 1575 MET A CG   1 
ATOM   1796 S  SD   A MET A 1 116 ? -8.31889  -4.37773  9.36647   0.534 20.25980 ? 1575 MET A SD   1 
ATOM   1797 S  SD   B MET A 1 116 ? -7.59348  -5.30648  7.73191   0.466 13.09593 ? 1575 MET A SD   1 
ATOM   1798 C  CE   A MET A 1 116 ? -9.93710  -4.00347  10.00219  0.534 16.06239 ? 1575 MET A CE   1 
ATOM   1799 C  CE   B MET A 1 116 ? -6.52546  -4.96211  9.13283   0.466 12.07496 ? 1575 MET A CE   1 
ATOM   1800 H  H    A MET A 1 116 ? -11.20065 -7.60892  8.20598   0.534 13.29298 ? 1575 MET A H    1 
ATOM   1801 H  H    B MET A 1 116 ? -11.20446 -7.60742  8.19515   0.466 13.29298 ? 1575 MET A H    1 
ATOM   1802 H  HA   A MET A 1 116 ? -8.77253  -8.20436  7.60222   0.534 14.89407 ? 1575 MET A HA   1 
ATOM   1803 H  HA   B MET A 1 116 ? -8.76600  -8.13645  7.64436   0.466 13.39073 ? 1575 MET A HA   1 
ATOM   1804 H  HB2  A MET A 1 116 ? -9.79174  -6.85159  9.82306   0.534 16.58073 ? 1575 MET A HB2  1 
ATOM   1805 H  HB2  B MET A 1 116 ? -9.80467  -7.00753  10.00524  0.466 12.20335 ? 1575 MET A HB2  1 
ATOM   1806 H  HB3  A MET A 1 116 ? -8.23259  -7.13997  9.71673   0.534 16.58073 ? 1575 MET A HB3  1 
ATOM   1807 H  HB3  B MET A 1 116 ? -8.24164  -7.09659  9.73242   0.466 12.20335 ? 1575 MET A HB3  1 
ATOM   1808 H  HG2  A MET A 1 116 ? -8.22105  -5.94033  7.67715   0.534 20.76531 ? 1575 MET A HG2  1 
ATOM   1809 H  HG2  B MET A 1 116 ? -9.88367  -5.66583  7.96520   0.466 12.93920 ? 1575 MET A HG2  1 
ATOM   1810 H  HG3  A MET A 1 116 ? -9.73102  -5.53559  7.96278   0.534 20.76531 ? 1575 MET A HG3  1 
ATOM   1811 H  HG3  B MET A 1 116 ? -9.30969  -4.96305  9.26983   0.466 12.93920 ? 1575 MET A HG3  1 
ATOM   1812 H  HE1  A MET A 1 116 ? -9.98290  -3.05758  10.21219  0.534 19.27487 ? 1575 MET A HE1  1 
ATOM   1813 H  HE1  B MET A 1 116 ? -5.66414  -4.65831  8.80613   0.466 14.48996 ? 1575 MET A HE1  1 
ATOM   1814 H  HE2  A MET A 1 116 ? -10.59977 -4.22542  9.32951   0.534 19.27487 ? 1575 MET A HE2  1 
ATOM   1815 H  HE2  B MET A 1 116 ? -6.93389  -4.27261  9.67934   0.466 14.48996 ? 1575 MET A HE2  1 
ATOM   1816 H  HE3  A MET A 1 116 ? -10.09068 -4.52802  10.80354  0.534 19.27487 ? 1575 MET A HE3  1 
ATOM   1817 H  HE3  B MET A 1 116 ? -6.41463  -5.77366  9.65245   0.466 14.48996 ? 1575 MET A HE3  1 
ATOM   1818 N  N    . GLU A 1 117 ? -9.88844  -9.90470  10.11866  1.000 11.28009 ? 1576 GLU A N    1 
ATOM   1819 C  CA   . GLU A 1 117 ? -9.63929  -11.10891 10.90549  1.000 11.76697 ? 1576 GLU A CA   1 
ATOM   1820 C  C    . GLU A 1 117 ? -9.46990  -12.33554 10.03419  1.000 11.00903 ? 1576 GLU A C    1 
ATOM   1821 O  O    . GLU A 1 117 ? -8.57657  -13.14951 10.29689  1.000 12.79861 ? 1576 GLU A O    1 
ATOM   1822 C  CB   . GLU A 1 117 ? -10.76680 -11.31311 11.89460  1.000 12.92769 ? 1576 GLU A CB   1 
ATOM   1823 C  CG   . GLU A 1 117 ? -10.77651 -10.28176 13.02381  1.000 15.89904 ? 1576 GLU A CG   1 
ATOM   1824 C  CD   . GLU A 1 117 ? -12.04929 -10.30069 13.85382  1.000 17.84144 ? 1576 GLU A CD   1 
ATOM   1825 O  OE1  . GLU A 1 117 ? -13.03815 -10.96251 13.48600  1.000 19.05988 ? 1576 GLU A OE1  1 
ATOM   1826 O  OE2  . GLU A 1 117 ? -12.09556 -9.63200  14.89881  1.000 20.01254 ? 1576 GLU A OE2  1 
ATOM   1827 H  H    . GLU A 1 117 ? -10.62663 -9.50397  10.30326  1.000 13.53610 ? 1576 GLU A H    1 
ATOM   1828 H  HA   . GLU A 1 117 ? -8.81190  -10.98790 11.39711  1.000 14.12036 ? 1576 GLU A HA   1 
ATOM   1829 H  HB2  . GLU A 1 117 ? -11.61238 -11.24743 11.42388  1.000 15.51323 ? 1576 GLU A HB2  1 
ATOM   1830 H  HB3  . GLU A 1 117 ? -10.67728 -12.19217 12.29478  1.000 15.51323 ? 1576 GLU A HB3  1 
ATOM   1831 H  HG2  . GLU A 1 117 ? -10.03196 -10.46222 13.61878  1.000 19.07885 ? 1576 GLU A HG2  1 
ATOM   1832 H  HG3  . GLU A 1 117 ? -10.68664 -9.39583  12.63918  1.000 19.07885 ? 1576 GLU A HG3  1 
ATOM   1833 N  N    . HIS A 1 118 ? -10.27291 -12.48175 8.99630   1.000 11.11951 ? 1577 HIS A N    1 
ATOM   1834 C  CA   . HIS A 1 118 ? -10.08319 -13.60403 8.07412   1.000 10.36684 ? 1577 HIS A CA   1 
ATOM   1835 C  C    . HIS A 1 118 ? -8.74687  -13.53760 7.33645   1.000 11.72482 ? 1577 HIS A C    1 
ATOM   1836 O  O    . HIS A 1 118 ? -8.01042  -14.52391 7.26219   1.000 12.30648 ? 1577 HIS A O    1 
ATOM   1837 C  CB   . HIS A 1 118 ? -11.25104 -13.71788 7.10882   1.000 10.59055 ? 1577 HIS A CB   1 
ATOM   1838 C  CG   . HIS A 1 118 ? -12.39320 -14.46905 7.68050   1.000 11.76702 ? 1577 HIS A CG   1 
ATOM   1839 N  ND1  . HIS A 1 118 ? -12.29563 -15.80927 7.99300   1.000 12.08278 ? 1577 HIS A ND1  1 
ATOM   1840 C  CD2  . HIS A 1 118 ? -13.61478 -14.04477 8.08170   1.000 13.35651 ? 1577 HIS A CD2  1 
ATOM   1841 C  CE1  . HIS A 1 118 ? -13.42531 -16.16418 8.56517   1.000 12.12489 ? 1577 HIS A CE1  1 
ATOM   1842 N  NE2  . HIS A 1 118 ? -14.23687 -15.12113 8.62911   1.000 12.45125 ? 1577 HIS A NE2  1 
ATOM   1843 H  H    . HIS A 1 118 ? -10.92652 -11.95863 8.79950   1.000 13.34341 ? 1577 HIS A H    1 
ATOM   1844 H  HA   . HIS A 1 118 ? -10.06805 -14.41627 8.60415   1.000 12.44021 ? 1577 HIS A HA   1 
ATOM   1845 H  HB2  . HIS A 1 118 ? -11.56072 -12.82735 6.88089   1.000 12.70866 ? 1577 HIS A HB2  1 
ATOM   1846 H  HB3  . HIS A 1 118 ? -10.95629 -14.18138 6.30933   1.000 12.70866 ? 1577 HIS A HB3  1 
ATOM   1847 H  HD2  . HIS A 1 118 ? -13.96011 -13.18525 7.99878   1.000 16.02781 ? 1577 HIS A HD2  1 
ATOM   1848 H  HE1  . HIS A 1 118 ? -13.62341 -17.01762 8.87710   1.000 14.54987 ? 1577 HIS A HE1  1 
ATOM   1849 H  HE2  . HIS A 1 118 ? -15.02942 -15.12413 8.96298   1.000 14.94150 ? 1577 HIS A HE2  1 
ATOM   1850 N  N    . PHE A 1 119 ? -8.39366  -12.36081 6.80954   1.000 12.04325 ? 1578 PHE A N    1 
ATOM   1851 C  CA   . PHE A 1 119 ? -7.12171  -12.20570 6.12102   1.000 11.22485 ? 1578 PHE A CA   1 
ATOM   1852 C  C    . PHE A 1 119 ? -5.92195  -12.44904 7.04425   1.000 11.60380 ? 1578 PHE A C    1 
ATOM   1853 O  O    . PHE A 1 119 ? -4.87266  -12.91748 6.58970   1.000 12.49068 ? 1578 PHE A O    1 
ATOM   1854 C  CB   . PHE A 1 119 ? -7.02772  -10.79736 5.48600   1.000 11.58798 ? 1578 PHE A CB   1 
ATOM   1855 C  CG   . PHE A 1 119 ? -7.58241  -10.71474 4.07747   1.000 10.79321 ? 1578 PHE A CG   1 
ATOM   1856 C  CD1  . PHE A 1 119 ? -8.95893  -10.70745 3.83574   1.000 10.97999 ? 1578 PHE A CD1  1 
ATOM   1857 C  CD2  . PHE A 1 119 ? -6.74950  -10.62381 3.00534   1.000 10.34581 ? 1578 PHE A CD2  1 
ATOM   1858 C  CE1  . PHE A 1 119 ? -9.41435  -10.60900 2.56577   1.000 11.98531 ? 1578 PHE A CE1  1 
ATOM   1859 C  CE2  . PHE A 1 119 ? -7.20188  -10.53961 1.73286   1.000 10.71421 ? 1578 PHE A CE2  1 
ATOM   1860 C  CZ   . PHE A 1 119 ? -8.59071  -10.53543 1.49549   1.000 11.14055 ? 1578 PHE A CZ   1 
ATOM   1861 H  H    . PHE A 1 119 ? -8.87131  -11.64627 6.83926   1.000 14.45191 ? 1578 PHE A H    1 
ATOM   1862 H  HA   . PHE A 1 119 ? -7.08260  -12.86553 5.41110   1.000 13.46981 ? 1578 PHE A HA   1 
ATOM   1863 H  HB2  . PHE A 1 119 ? -7.52774  -10.17455 6.03645   1.000 13.90557 ? 1578 PHE A HB2  1 
ATOM   1864 H  HB3  . PHE A 1 119 ? -6.09477  -10.53415 5.45104   1.000 13.90557 ? 1578 PHE A HB3  1 
ATOM   1865 H  HD1  . PHE A 1 119 ? -9.55842  -10.76993 4.54398   1.000 13.17599 ? 1578 PHE A HD1  1 
ATOM   1866 H  HD2  . PHE A 1 119 ? -5.83135  -10.61935 3.15326   1.000 12.41497 ? 1578 PHE A HD2  1 
ATOM   1867 H  HE1  . PHE A 1 119 ? -10.33308 -10.59113 2.42248   1.000 14.38237 ? 1578 PHE A HE1  1 
ATOM   1868 H  HE2  . PHE A 1 119 ? -6.60315  -10.48515 1.02332   1.000 12.85705 ? 1578 PHE A HE2  1 
ATOM   1869 H  HZ   . PHE A 1 119 ? -8.92999  -10.48377 0.63112   1.000 13.36866 ? 1578 PHE A HZ   1 
ATOM   1870 N  N    . GLU A 1 120 ? -6.06900  -12.14039 8.32864   1.000 11.74856 ? 1579 GLU A N    1 
ATOM   1871 C  CA   . GLU A 1 120 ? -5.01192  -12.33829 9.30901   1.000 13.28556 ? 1579 GLU A CA   1 
ATOM   1872 C  C    . GLU A 1 120 ? -4.85772  -13.79022 9.73240   1.000 14.35679 ? 1579 GLU A C    1 
ATOM   1873 O  O    . GLU A 1 120 ? -3.74155  -14.22888 10.04879  1.000 17.20698 ? 1579 GLU A O    1 
ATOM   1874 C  CB   . GLU A 1 120 ? -5.30218  -11.49529 10.54873  1.000 14.38046 ? 1579 GLU A CB   1 
ATOM   1875 C  CG   . GLU A 1 120 ? -5.00884  -10.05610 10.35802  1.000 16.59646 ? 1579 GLU A CG   1 
ATOM   1876 C  CD   . GLU A 1 120 ? -5.67984  -9.15079  11.37266  1.000 18.55998 ? 1579 GLU A CD   1 
ATOM   1877 O  OE1  . GLU A 1 120 ? -6.48661  -9.63675  12.21759  1.000 20.06260 ? 1579 GLU A OE1  1 
ATOM   1878 O  OE2  . GLU A 1 120 ? -5.43008  -7.94034  11.29050  1.000 21.58385 ? 1579 GLU A OE2  1 
ATOM   1879 H  H    . GLU A 1 120 ? -6.78728  -11.80761 8.66470   1.000 14.09827 ? 1579 GLU A H    1 
ATOM   1880 H  HA   . GLU A 1 120 ? -4.17571  -12.05312 8.90860   1.000 15.94268 ? 1579 GLU A HA   1 
ATOM   1881 H  HB2  . GLU A 1 120 ? -6.24183  -11.58109 10.77368  1.000 17.25655 ? 1579 GLU A HB2  1 
ATOM   1882 H  HB3  . GLU A 1 120 ? -4.75478  -11.81680 11.28214  1.000 17.25655 ? 1579 GLU A HB3  1 
ATOM   1883 H  HG2  . GLU A 1 120 ? -4.05101  -9.92124  10.43062  1.000 19.91575 ? 1579 GLU A HG2  1 
ATOM   1884 H  HG3  . GLU A 1 120 ? -5.31554  -9.78985  9.47714   1.000 19.91575 ? 1579 GLU A HG3  1 
ATOM   1885 N  N    . THR A 1 121 ? -5.94199  -14.55487 9.75433   1.000 13.38029 ? 1580 THR A N    1 
ATOM   1886 C  CA   . THR A 1 121 ? -5.93417  -15.90134 10.33759  1.000 12.25132 ? 1580 THR A CA   1 
ATOM   1887 C  C    . THR A 1 121 ? -5.86961  -17.01365 9.28933   1.000 11.89603 ? 1580 THR A C    1 
ATOM   1888 O  O    . THR A 1 121 ? -5.29941  -18.07539 9.54116   1.000 13.73291 ? 1580 THR A O    1 
ATOM   1889 C  CB   . THR A 1 121 ? -7.16257  -16.14698 11.22332  1.000 13.60932 ? 1580 THR A CB   1 
ATOM   1890 O  OG1  . THR A 1 121 ? -8.36302  -15.90230 10.49705  1.000 13.49876 ? 1580 THR A OG1  1 
ATOM   1891 C  CG2  . THR A 1 121 ? -7.14707  -15.30445 12.45947  1.000 15.68310 ? 1580 THR A CG2  1 
ATOM   1892 H  H    . THR A 1 121 ? -6.70485  -14.31826 9.43549   1.000 16.05635 ? 1580 THR A H    1 
ATOM   1893 H  HA   . THR A 1 121 ? -5.14930  -15.95874 10.90467  1.000 14.70159 ? 1580 THR A HA   1 
ATOM   1894 H  HB   . THR A 1 121 ? -7.14178  -17.07541 11.50349  1.000 16.33118 ? 1580 THR A HB   1 
ATOM   1895 H  HG1  . THR A 1 121 ? -9.02955  -16.03400 10.99100  1.000 16.19851 ? 1580 THR A HG1  1 
ATOM   1896 H  HG21 . THR A 1 121 ? -7.93415  -15.48791 12.99589  1.000 18.81973 ? 1580 THR A HG21 1 
ATOM   1897 H  HG22 . THR A 1 121 ? -6.35547  -15.50048 12.98467  1.000 18.81973 ? 1580 THR A HG22 1 
ATOM   1898 H  HG23 . THR A 1 121 ? -7.14129  -14.36444 12.22021  1.000 18.81973 ? 1580 THR A HG23 1 
ATOM   1899 N  N    . TRP A 1 122 ? -6.52253  -16.85739 8.16481   1.000 11.90114 ? 1581 TRP A N    1 
ATOM   1900 C  CA   . TRP A 1 122 ? -6.44695  -17.83862 7.08466   1.000 11.14848 ? 1581 TRP A CA   1 
ATOM   1901 C  C    . TRP A 1 122 ? -4.98801  -18.00355 6.69065   1.000 12.18013 ? 1581 TRP A C    1 
ATOM   1902 O  O    . TRP A 1 122 ? -4.25240  -17.00147 6.62715   1.000 13.48817 ? 1581 TRP A O    1 
ATOM   1903 C  CB   . TRP A 1 122 ? -7.29383  -17.34664 5.90746   1.000 10.69839 ? 1581 TRP A CB   1 
ATOM   1904 C  CG   . TRP A 1 122 ? -7.37581  -18.25280 4.72349   1.000 9.94310  ? 1581 TRP A CG   1 
ATOM   1905 C  CD1  . TRP A 1 122 ? -6.81806  -18.07383 3.50999   1.000 10.45101 ? 1581 TRP A CD1  1 
ATOM   1906 C  CD2  . TRP A 1 122 ? -8.09494  -19.49874 4.62979   1.000 10.77471 ? 1581 TRP A CD2  1 
ATOM   1907 N  NE1  . TRP A 1 122 ? -7.10984  -19.10919 2.65525   1.000 10.60890 ? 1581 TRP A NE1  1 
ATOM   1908 C  CE2  . TRP A 1 122 ? -7.88833  -20.00239 3.34173   1.000 10.16415 ? 1581 TRP A CE2  1 
ATOM   1909 C  CE3  . TRP A 1 122 ? -8.90999  -20.19323 5.50312   1.000 11.35113 ? 1581 TRP A CE3  1 
ATOM   1910 C  CZ2  . TRP A 1 122 ? -8.47891  -21.19175 2.90074   1.000 10.25103 ? 1581 TRP A CZ2  1 
ATOM   1911 C  CZ3  . TRP A 1 122 ? -9.49064  -21.36697 5.09762   1.000 12.32223 ? 1581 TRP A CZ3  1 
ATOM   1912 C  CH2  . TRP A 1 122 ? -9.26667  -21.85141 3.77951   1.000 11.80116 ? 1581 TRP A CH2  1 
ATOM   1913 H  H    . TRP A 1 122 ? -7.02824  -16.18498 7.98671   1.000 14.28137 ? 1581 TRP A H    1 
ATOM   1914 H  HA   . TRP A 1 122 ? -6.78687  -18.70623 7.35412   1.000 13.37818 ? 1581 TRP A HA   1 
ATOM   1915 H  HB2  . TRP A 1 122 ? -8.20032  -17.20990 6.22443   1.000 12.83807 ? 1581 TRP A HB2  1 
ATOM   1916 H  HB3  . TRP A 1 122 ? -6.92048  -16.50670 5.59761   1.000 12.83807 ? 1581 TRP A HB3  1 
ATOM   1917 H  HD1  . TRP A 1 122 ? -6.29823  -17.33813 3.27886   1.000 12.54121 ? 1581 TRP A HD1  1 
ATOM   1918 H  HE1  . TRP A 1 122 ? -6.85091  -19.18284 1.83847   1.000 12.73068 ? 1581 TRP A HE1  1 
ATOM   1919 H  HE3  . TRP A 1 122 ? -9.06359  -19.86659 6.36021   1.000 13.62136 ? 1581 TRP A HE3  1 
ATOM   1920 H  HZ2  . TRP A 1 122 ? -8.33577  -21.51454 2.04039   1.000 12.30124 ? 1581 TRP A HZ2  1 
ATOM   1921 H  HZ3  . TRP A 1 122 ? -10.03056 -21.84602 5.68405   1.000 14.78668 ? 1581 TRP A HZ3  1 
ATOM   1922 H  HH2  . TRP A 1 122 ? -9.67363  -22.64452 3.51443   1.000 14.16139 ? 1581 TRP A HH2  1 
ATOM   1923 N  N    . PRO A 1 123 ? -4.50575  -19.23582 6.41221   1.000 11.99077 ? 1582 PRO A N    1 
ATOM   1924 C  CA   . PRO A 1 123 ? -3.07320  -19.36794 6.09480   1.000 12.67495 ? 1582 PRO A CA   1 
ATOM   1925 C  C    . PRO A 1 123 ? -2.70655  -18.51819 4.88927   1.000 12.96190 ? 1582 PRO A C    1 
ATOM   1926 O  O    . PRO A 1 123 ? -3.41704  -18.46912 3.88194   1.000 12.64606 ? 1582 PRO A O    1 
ATOM   1927 C  CB   . PRO A 1 123 ? -2.91280  -20.86267 5.83630   1.000 12.74074 ? 1582 PRO A CB   1 
ATOM   1928 C  CG   . PRO A 1 123 ? -3.99472  -21.48345 6.67743   1.000 13.34079 ? 1582 PRO A CG   1 
ATOM   1929 C  CD   . PRO A 1 123 ? -5.19322  -20.56293 6.51523   1.000 12.62761 ? 1582 PRO A CD   1 
ATOM   1930 H  HA   . PRO A 1 123 ? -2.51319  -19.11551 6.84551   1.000 15.20994 ? 1582 PRO A HA   1 
ATOM   1931 H  HB2  . PRO A 1 123 ? -3.04317  -21.05682 4.89491   1.000 15.28889 ? 1582 PRO A HB2  1 
ATOM   1932 H  HB3  . PRO A 1 123 ? -2.03339  -21.15992 6.11767   1.000 15.28889 ? 1582 PRO A HB3  1 
ATOM   1933 H  HG2  . PRO A 1 123 ? -4.19568  -22.37514 6.35278   1.000 16.00894 ? 1582 PRO A HG2  1 
ATOM   1934 H  HG3  . PRO A 1 123 ? -3.71121  -21.52387 7.60420   1.000 16.00894 ? 1582 PRO A HG3  1 
ATOM   1935 H  HD2  . PRO A 1 123 ? -5.69309  -20.76819 5.70968   1.000 15.15313 ? 1582 PRO A HD2  1 
ATOM   1936 H  HD3  . PRO A 1 123 ? -5.77857  -20.60142 7.28775   1.000 15.15313 ? 1582 PRO A HD3  1 
ATOM   1937 N  N    . SER A 1 124 ? -1.55234  -17.84581 5.00465   1.000 15.29894 ? 1583 SER A N    1 
ATOM   1938 C  CA   . SER A 1 124 ? -1.22453  -16.80918 4.03600   1.000 18.00982 ? 1583 SER A CA   1 
ATOM   1939 C  C    . SER A 1 124 ? -0.91559  -17.35933 2.65720   1.000 16.50970 ? 1583 SER A C    1 
ATOM   1940 O  O    . SER A 1 124 ? -0.96101  -16.60246 1.68961   1.000 18.77302 ? 1583 SER A O    1 
ATOM   1941 C  CB   . SER A 1 124 ? -0.02938  -15.99428 4.54481   1.000 23.33137 ? 1583 SER A CB   1 
ATOM   1942 O  OG   . SER A 1 124 ? 1.13139   -16.80489 4.51592   1.000 25.08948 ? 1583 SER A OG   1 
ATOM   1943 H  H    . SER A 1 124 ? -0.96377  -17.97194 5.61888   1.000 18.35873 ? 1583 SER A H    1 
ATOM   1944 H  HA   . SER A 1 124 ? -1.99031  -16.22063 3.94609   1.000 21.61179 ? 1583 SER A HA   1 
ATOM   1945 H  HB2  . SER A 1 124 ? 0.10192   -15.22242 3.97219   1.000 27.99765 ? 1583 SER A HB2  1 
ATOM   1946 H  HB3  . SER A 1 124 ? -0.19935  -15.70670 5.45547   1.000 27.99765 ? 1583 SER A HB3  1 
ATOM   1947 H  HG   . SER A 1 124 ? 1.02194   -17.48084 5.00244   1.000 30.10737 ? 1583 SER A HG   1 
ATOM   1948 N  N    . HIS A 1 125 ? -0.57737  -18.65043 2.54128   1.000 14.89105 ? 1584 HIS A N    1 
ATOM   1949 C  CA   . HIS A 1 125 ? -0.26958  -19.23367 1.24804   1.000 14.41728 ? 1584 HIS A CA   1 
ATOM   1950 C  C    . HIS A 1 125 ? -1.51654  -19.74843 0.52025   1.000 12.80658 ? 1584 HIS A C    1 
ATOM   1951 O  O    . HIS A 1 125 ? -1.41022  -20.19128 -0.61906  1.000 14.07504 ? 1584 HIS A O    1 
ATOM   1952 C  CB   . HIS A 1 125 ? 0.76219   -20.37224 1.41420   1.000 15.71736 ? 1584 HIS A CB   1 
ATOM   1953 C  CG   . HIS A 1 125 ? 0.22282   -21.54938 2.16819   1.000 15.17528 ? 1584 HIS A CG   1 
ATOM   1954 N  ND1  . HIS A 1 125 ? -0.04446  -21.50765 3.51313   1.000 15.92535 ? 1584 HIS A ND1  1 
ATOM   1955 C  CD2  . HIS A 1 125 ? -0.09614  -22.79662 1.75274   1.000 15.19366 ? 1584 HIS A CD2  1 
ATOM   1956 C  CE1  . HIS A 1 125 ? -0.51730  -22.68889 3.90235   1.000 16.48328 ? 1584 HIS A CE1  1 
ATOM   1957 N  NE2  . HIS A 1 125 ? -0.55270  -23.48802 2.84518   1.000 14.95946 ? 1584 HIS A NE2  1 
ATOM   1958 H  H    . HIS A 1 125 ? -0.52187  -19.20007 3.20038   1.000 17.86926 ? 1584 HIS A H    1 
ATOM   1959 H  HA   . HIS A 1 125 ? 0.13730   -18.55960 0.68149   1.000 17.30073 ? 1584 HIS A HA   1 
ATOM   1960 H  HB2  . HIS A 1 125 ? 1.03523   -20.67973 0.53569   1.000 18.86083 ? 1584 HIS A HB2  1 
ATOM   1961 H  HB3  . HIS A 1 125 ? 1.52983   -20.03240 1.90014   1.000 18.86083 ? 1584 HIS A HB3  1 
ATOM   1962 H  HD1  . HIS A 1 125 ? 0.07473   -20.82600 4.02377   1.000 19.11042 ? 1584 HIS A HD1  1 
ATOM   1963 H  HD2  . HIS A 1 125 ? -0.01980  -23.12467 0.88587   1.000 18.23239 ? 1584 HIS A HD2  1 
ATOM   1964 H  HE1  . HIS A 1 125 ? -0.77776  -22.91472 4.76610   1.000 19.77994 ? 1584 HIS A HE1  1 
ATOM   1965 N  N    . LEU A 1 126 ? -2.66244  -19.74016 1.16176   1.000 11.34858 ? 1585 LEU A N    1 
ATOM   1966 C  CA   . LEU A 1 126 ? -3.85806  -20.34360 0.53635   1.000 10.49844 ? 1585 LEU A CA   1 
ATOM   1967 C  C    . LEU A 1 126 ? -4.77623  -19.28454 -0.08004  1.000 10.17469 ? 1585 LEU A C    1 
ATOM   1968 O  O    . LEU A 1 126 ? -4.79554  -18.12240 0.34223   1.000 10.71418 ? 1585 LEU A O    1 
ATOM   1969 C  CB   . LEU A 1 126 ? -4.62586  -21.11724 1.59410   1.000 10.49842 ? 1585 LEU A CB   1 
ATOM   1970 C  CG   . LEU A 1 126 ? -3.88019  -22.35104 2.15652   1.000 11.54324 ? 1585 LEU A CG   1 
ATOM   1971 C  CD1  . LEU A 1 126 ? -4.67340  -22.94811 3.29174   1.000 11.78798 ? 1585 LEU A CD1  1 
ATOM   1972 C  CD2  . LEU A 1 126 ? -3.55485  -23.40053 1.04904   1.000 12.75917 ? 1585 LEU A CD2  1 
ATOM   1973 H  H    . LEU A 1 126 ? -2.78939  -19.40356 1.94291   1.000 13.61829 ? 1585 LEU A H    1 
ATOM   1974 H  HA   . LEU A 1 126 ? -3.59185  -20.94002 -0.18081  1.000 12.59813 ? 1585 LEU A HA   1 
ATOM   1975 H  HB2  . LEU A 1 126 ? -4.81071  -20.52215 2.33747   1.000 12.59811 ? 1585 LEU A HB2  1 
ATOM   1976 H  HB3  . LEU A 1 126 ? -5.45743  -21.42951 1.20440   1.000 12.59811 ? 1585 LEU A HB3  1 
ATOM   1977 H  HG   . LEU A 1 126 ? -3.01936  -22.06932 2.50367   1.000 13.85188 ? 1585 LEU A HG   1 
ATOM   1978 H  HD11 . LEU A 1 126 ? -4.18514  -23.70335 3.65521   1.000 14.14557 ? 1585 LEU A HD11 1 
ATOM   1979 H  HD12 . LEU A 1 126 ? -4.79896  -22.27417 3.97799   1.000 14.14557 ? 1585 LEU A HD12 1 
ATOM   1980 H  HD13 . LEU A 1 126 ? -5.53439  -23.24188 2.95516   1.000 14.14557 ? 1585 LEU A HD13 1 
ATOM   1981 H  HD21 . LEU A 1 126 ? -3.21608  -24.20711 1.46804   1.000 15.31100 ? 1585 LEU A HD21 1 
ATOM   1982 H  HD22 . LEU A 1 126 ? -4.36543  -23.59986 0.55495   1.000 15.31100 ? 1585 LEU A HD22 1 
ATOM   1983 H  HD23 . LEU A 1 126 ? -2.88546  -23.03197 0.45156   1.000 15.31100 ? 1585 LEU A HD23 1 
ATOM   1984 N  N    . PRO A 1 127 ? -5.50968  -19.62886 -1.14053  1.000 10.35627 ? 1586 PRO A N    1 
ATOM   1985 C  CA   . PRO A 1 127 ? -6.30100  -18.62199 -1.84340  1.000 10.20360 ? 1586 PRO A CA   1 
ATOM   1986 C  C    . PRO A 1 127 ? -7.40311  -18.01979 -1.01479  1.000 10.26672 ? 1586 PRO A C    1 
ATOM   1987 O  O    . PRO A 1 127 ? -8.04038  -18.69534 -0.19740  1.000 10.02465 ? 1586 PRO A O    1 
ATOM   1988 C  CB   . PRO A 1 127 ? -6.87691  -19.39112 -3.02952  1.000 10.20361 ? 1586 PRO A CB   1 
ATOM   1989 C  CG   . PRO A 1 127 ? -5.92939  -20.57370 -3.20652  1.000 10.72731 ? 1586 PRO A CG   1 
ATOM   1990 C  CD   . PRO A 1 127 ? -5.52367  -20.93322 -1.83782  1.000 10.39840 ? 1586 PRO A CD   1 
ATOM   1991 H  HA   . PRO A 1 127 ? -5.70967  -17.91081 -2.13571  1.000 12.24432 ? 1586 PRO A HA   1 
ATOM   1992 H  HB2  . PRO A 1 127 ? -7.77677  -19.69118 -2.82673  1.000 12.24433 ? 1586 PRO A HB2  1 
ATOM   1993 H  HB3  . PRO A 1 127 ? -6.88502  -18.82812 -3.81936  1.000 12.24433 ? 1586 PRO A HB3  1 
ATOM   1994 H  HG2  . PRO A 1 127 ? -6.39298  -21.30923 -3.63661  1.000 12.87278 ? 1586 PRO A HG2  1 
ATOM   1995 H  HG3  . PRO A 1 127 ? -5.16282  -20.30835 -3.73836  1.000 12.87278 ? 1586 PRO A HG3  1 
ATOM   1996 H  HD2  . PRO A 1 127 ? -6.16728  -21.53542 -1.43284  1.000 12.47808 ? 1586 PRO A HD2  1 
ATOM   1997 H  HD3  . PRO A 1 127 ? -4.64210  -21.33782 -1.83305  1.000 12.47808 ? 1586 PRO A HD3  1 
ATOM   1998 N  N    . ILE A 1 128 ? -7.62690  -16.72092 -1.25075  1.000 9.65097  ? 1587 ILE A N    1 
ATOM   1999 C  CA   . ILE A 1 128 ? -8.81574  -16.01541 -0.77786  1.000 9.14563  ? 1587 ILE A CA   1 
ATOM   2000 C  C    . ILE A 1 128 ? -9.47208  -15.39156 -1.99294  1.000 9.04293  ? 1587 ILE A C    1 
ATOM   2001 O  O    . ILE A 1 128 ? -8.83983  -14.67764 -2.77176  1.000 9.40613  ? 1587 ILE A O    1 
ATOM   2002 C  CB   . ILE A 1 128 ? -8.48874  -14.92115 0.26120   1.000 10.34846 ? 1587 ILE A CB   1 
ATOM   2003 C  CG1  . ILE A 1 128 ? -7.88955  -15.49521 1.51581   1.000 11.59323 ? 1587 ILE A CG1  1 
ATOM   2004 C  CG2  . ILE A 1 128 ? -9.78621  -14.14819 0.54362   1.000 12.65385 ? 1587 ILE A CG2  1 
ATOM   2005 C  CD1  . ILE A 1 128 ? -7.51643  -14.48243 2.58153   1.000 12.94859 ? 1587 ILE A CD1  1 
ATOM   2006 H  H    . ILE A 1 128 ? -7.08794  -16.21853 -1.69428  1.000 11.58116 ? 1587 ILE A H    1 
ATOM   2007 H  HA   . ILE A 1 128 ? -9.41625  -16.65149 -0.35870  1.000 10.97476 ? 1587 ILE A HA   1 
ATOM   2008 H  HB   . ILE A 1 128 ? -7.81400  -14.32171 -0.09419  1.000 12.41815 ? 1587 ILE A HB   1 
ATOM   2009 H  HG12 . ILE A 1 128 ? -8.53233  -16.10561 1.90969   1.000 13.91187 ? 1587 ILE A HG12 1 
ATOM   2010 H  HG13 . ILE A 1 128 ? -7.08069  -15.97416 1.27655   1.000 13.91187 ? 1587 ILE A HG13 1 
ATOM   2011 H  HG21 . ILE A 1 128 ? -9.68478  -13.65261 1.37127   1.000 15.18463 ? 1587 ILE A HG21 1 
ATOM   2012 H  HG22 . ILE A 1 128 ? -9.95525  -13.53625 -0.18976  1.000 15.18463 ? 1587 ILE A HG22 1 
ATOM   2013 H  HG23 . ILE A 1 128 ? -10.51865 -14.77911 0.62350   1.000 15.18463 ? 1587 ILE A HG23 1 
ATOM   2014 H  HD11 . ILE A 1 128 ? -6.91447  -14.90013 3.21720   1.000 15.53831 ? 1587 ILE A HD11 1 
ATOM   2015 H  HD12 . ILE A 1 128 ? -7.07915  -13.72642 2.15946   1.000 15.53831 ? 1587 ILE A HD12 1 
ATOM   2016 H  HD13 . ILE A 1 128 ? -8.32262  -14.18815 3.03359   1.000 15.53831 ? 1587 ILE A HD13 1 
ATOM   2017 N  N    . VAL A 1 129 ? -10.76763 -15.64493 -2.15564  1.000 9.04831  ? 1588 VAL A N    1 
ATOM   2018 C  CA   . VAL A 1 129 ? -11.55551 -15.04710 -3.21590  1.000 10.54302 ? 1588 VAL A CA   1 
ATOM   2019 C  C    . VAL A 1 129 ? -12.70617 -14.28012 -2.59357  1.000 9.29827  ? 1588 VAL A C    1 
ATOM   2020 O  O    . VAL A 1 129 ? -13.19825 -14.64127 -1.52529  1.000 10.13255 ? 1588 VAL A O    1 
ATOM   2021 C  CB   . VAL A 1 129 ? -12.05574 -16.08467 -4.24690  1.000 10.37476 ? 1588 VAL A CB   1 
ATOM   2022 C  CG1  . VAL A 1 129 ? -10.92456 -16.99229 -4.71498  1.000 10.30100 ? 1588 VAL A CG1  1 
ATOM   2023 C  CG2  . VAL A 1 129 ? -13.14338 -16.93288 -3.65658  1.000 11.63524 ? 1588 VAL A CG2  1 
ATOM   2024 H  H    . VAL A 1 129 ? -11.21905 -16.17358 -1.64933  1.000 10.85797 ? 1588 VAL A H    1 
ATOM   2025 H  HA   . VAL A 1 129 ? -11.00113 -14.41421 -3.69862  1.000 12.65163 ? 1588 VAL A HA   1 
ATOM   2026 H  HB   . VAL A 1 129 ? -12.40134 -15.59598 -5.01021  1.000 12.44971 ? 1588 VAL A HB   1 
ATOM   2027 H  HG11 . VAL A 1 129 ? -11.15830 -17.36887 -5.57780  1.000 12.36121 ? 1588 VAL A HG11 1 
ATOM   2028 H  HG12 . VAL A 1 129 ? -10.11123 -16.46931 -4.79170  1.000 12.36121 ? 1588 VAL A HG12 1 
ATOM   2029 H  HG13 . VAL A 1 129 ? -10.80093 -17.70293 -4.06644  1.000 12.36121 ? 1588 VAL A HG13 1 
ATOM   2030 H  HG21 . VAL A 1 129 ? -13.25783 -17.72556 -4.20381  1.000 13.96229 ? 1588 VAL A HG21 1 
ATOM   2031 H  HG22 . VAL A 1 129 ? -12.89153 -17.18692 -2.75495  1.000 13.96229 ? 1588 VAL A HG22 1 
ATOM   2032 H  HG23 . VAL A 1 129 ? -13.96761 -16.42179 -3.63821  1.000 13.96229 ? 1588 VAL A HG23 1 
ATOM   2033 N  N    . ALA A 1 130 ? -13.16988 -13.23420 -3.28161  1.000 9.00870  ? 1589 ALA A N    1 
ATOM   2034 C  CA   . ALA A 1 130 ? -14.22984 -12.40277 -2.72799  1.000 9.20877  ? 1589 ALA A CA   1 
ATOM   2035 C  C    . ALA A 1 130 ? -15.27838 -12.04450 -3.76006  1.000 8.86137  ? 1589 ALA A C    1 
ATOM   2036 O  O    . ALA A 1 130 ? -14.96518 -11.63740 -4.87411  1.000 9.39297  ? 1589 ALA A O    1 
ATOM   2037 C  CB   . ALA A 1 130 ? -13.62610 -11.09354 -2.11755  1.000 9.82986  ? 1589 ALA A CB   1 
ATOM   2038 H  H    . ALA A 1 130 ? -12.88843 -12.99355 -4.05780  1.000 10.81045 ? 1589 ALA A H    1 
ATOM   2039 H  HA   . ALA A 1 130 ? -14.69177 -12.91351 -2.04486  1.000 11.05052 ? 1589 ALA A HA   1 
ATOM   2040 H  HB1  . ALA A 1 130 ? -14.34490 -10.55573 -1.75015  1.000 11.79583 ? 1589 ALA A HB1  1 
ATOM   2041 H  HB2  . ALA A 1 130 ? -12.99957 -11.33174 -1.41640  1.000 11.79583 ? 1589 ALA A HB2  1 
ATOM   2042 H  HB3  . ALA A 1 130 ? -13.16850 -10.60092 -2.81671  1.000 11.79583 ? 1589 ALA A HB3  1 
ATOM   2043 N  N    . HIS A 1 131 ? -16.54439 -12.12259 -3.31984  1.000 9.15608  ? 1590 HIS A N    1 
ATOM   2044 C  CA   . HIS A 1 131 ? -17.65735 -11.42632 -3.95516  1.000 8.86929  ? 1590 HIS A CA   1 
ATOM   2045 C  C    . HIS A 1 131 ? -17.60899 -9.97777  -3.43808  1.000 8.37971  ? 1590 HIS A C    1 
ATOM   2046 O  O    . HIS A 1 131 ? -17.82631 -9.74368  -2.26045  1.000 9.40348  ? 1590 HIS A O    1 
ATOM   2047 C  CB   . HIS A 1 131 ? -18.99103 -12.10740 -3.58738  1.000 9.05871  ? 1590 HIS A CB   1 
ATOM   2048 C  CG   . HIS A 1 131 ? -20.15074 -11.43164 -4.24881  1.000 9.53252  ? 1590 HIS A CG   1 
ATOM   2049 N  ND1  . HIS A 1 131 ? -21.08033 -12.13170 -4.99304  1.000 9.87719  ? 1590 HIS A ND1  1 
ATOM   2050 C  CD2  . HIS A 1 131 ? -20.51406 -10.11469 -4.27988  1.000 10.13782 ? 1590 HIS A CD2  1 
ATOM   2051 C  CE1  . HIS A 1 131 ? -21.97061 -11.27307 -5.45936  1.000 10.57997 ? 1590 HIS A CE1  1 
ATOM   2052 N  NE2  . HIS A 1 131 ? -21.63783 -10.05320 -5.07257  1.000 10.96942 ? 1590 HIS A NE2  1 
ATOM   2053 H  H    . HIS A 1 131 ? -16.78338 -12.58658 -2.63632  1.000 10.98730 ? 1590 HIS A H    1 
ATOM   2054 H  HA   . HIS A 1 131 ? -17.57885 -11.44019 -4.92188  1.000 10.64315 ? 1590 HIS A HA   1 
ATOM   2055 H  HB2  . HIS A 1 131 ? -18.96967 -13.03258 -3.87806  1.000 10.87045 ? 1590 HIS A HB2  1 
ATOM   2056 H  HB3  . HIS A 1 131 ? -19.11909 -12.06432 -2.62683  1.000 10.87045 ? 1590 HIS A HB3  1 
ATOM   2057 H  HD2  . HIS A 1 131 ? -20.08945 -9.40575  -3.85324  1.000 12.16538 ? 1590 HIS A HD2  1 
ATOM   2058 H  HE1  . HIS A 1 131 ? -22.71200 -11.49182 -5.97645  1.000 12.69597 ? 1590 HIS A HE1  1 
ATOM   2059 H  HE2  . HIS A 1 131 ? -22.05819 -9.33318  -5.28348  1.000 13.16331 ? 1590 HIS A HE2  1 
ATOM   2060 N  N    . ALA A 1 132 ? -17.14367 -9.07251  -4.30065  1.000 8.46925  ? 1591 ALA A N    1 
ATOM   2061 C  CA   . ALA A 1 132 ? -16.81122 -7.70883  -3.89990  1.000 9.84832  ? 1591 ALA A CA   1 
ATOM   2062 C  C    . ALA A 1 132 ? -17.14492 -6.81844  -5.09699  1.000 10.92741 ? 1591 ALA A C    1 
ATOM   2063 O  O    . ALA A 1 132 ? -16.37842 -6.73038  -6.05290  1.000 13.80125 ? 1591 ALA A O    1 
ATOM   2064 C  CB   . ALA A 1 132 ? -15.35356 -7.62152  -3.52328  1.000 10.45626 ? 1591 ALA A CB   1 
ATOM   2065 H  H    . ALA A 1 132 ? -17.01037 -9.22777  -5.13595  1.000 10.16310 ? 1591 ALA A H    1 
ATOM   2066 H  HA   . ALA A 1 132 ? -17.34526 -7.42780  -3.14048  1.000 11.81799 ? 1591 ALA A HA   1 
ATOM   2067 H  HB1  . ALA A 1 132 ? -15.15165 -6.71269  -3.25093  1.000 12.54752 ? 1591 ALA A HB1  1 
ATOM   2068 H  HB2  . ALA A 1 132 ? -15.17955 -8.23281  -2.79052  1.000 12.54752 ? 1591 ALA A HB2  1 
ATOM   2069 H  HB3  . ALA A 1 132 ? -14.81374 -7.86419  -4.29179  1.000 12.54752 ? 1591 ALA A HB3  1 
ATOM   2070 N  N    . GLU A 1 133 ? -18.25372 -6.10522  -5.02191  1.000 9.92469  ? 1592 GLU A N    1 
ATOM   2071 C  CA   . GLU A 1 133 ? -18.74963 -5.27368  -6.09976  1.000 10.04570 ? 1592 GLU A CA   1 
ATOM   2072 C  C    . GLU A 1 133 ? -18.47416 -3.78678  -5.84786  1.000 10.04836 ? 1592 GLU A C    1 
ATOM   2073 O  O    . GLU A 1 133 ? -18.54698 -3.29311  -4.72372  1.000 9.99567  ? 1592 GLU A O    1 
ATOM   2074 C  CB   . GLU A 1 133 ? -20.25238 -5.45876  -6.15849  1.000 10.85632 ? 1592 GLU A CB   1 
ATOM   2075 C  CG   . GLU A 1 133 ? -20.69539 -6.84013  -6.54454  1.000 11.58008 ? 1592 GLU A CG   1 
ATOM   2076 C  CD   . GLU A 1 133 ? -22.19397 -6.97182  -6.73316  1.000 11.58546 ? 1592 GLU A CD   1 
ATOM   2077 O  OE1  . GLU A 1 133 ? -22.71039 -6.14831  -7.52980  1.000 12.98545 ? 1592 GLU A OE1  1 
ATOM   2078 O  OE2  . GLU A 1 133 ? -22.83380 -7.86451  -6.09618  1.000 12.77492 ? 1592 GLU A OE2  1 
ATOM   2079 H  H    . GLU A 1 133 ? -18.75816 -6.08606  -4.32565  1.000 11.90963 ? 1592 GLU A H    1 
ATOM   2080 H  HA   . GLU A 1 133 ? -18.30944 -5.51529  -6.92967  1.000 12.05484 ? 1592 GLU A HA   1 
ATOM   2081 H  HB2  . GLU A 1 133 ? -20.62164 -5.26695  -5.28227  1.000 13.02758 ? 1592 GLU A HB2  1 
ATOM   2082 H  HB3  . GLU A 1 133 ? -20.61420 -4.84143  -6.81338  1.000 13.02758 ? 1592 GLU A HB3  1 
ATOM   2083 H  HG2  . GLU A 1 133 ? -20.26982 -7.08168  -7.38207  1.000 13.89610 ? 1592 GLU A HG2  1 
ATOM   2084 H  HG3  . GLU A 1 133 ? -20.42986 -7.45942  -5.84678  1.000 13.89610 ? 1592 GLU A HG3  1 
ATOM   2085 N  N    . GLN A 1 134 ? -18.17599 -3.10200  -6.92593  1.000 11.58268 ? 1593 GLN A N    1 
ATOM   2086 C  CA   . GLN A 1 134 ? -18.03957 -1.64216  -6.92972  1.000 11.97227 ? 1593 GLN A CA   1 
ATOM   2087 C  C    . GLN A 1 134 ? -17.02685 -1.20867  -5.86716  1.000 12.35125 ? 1593 GLN A C    1 
ATOM   2088 O  O    . GLN A 1 134 ? -15.89648 -1.71600  -5.86402  1.000 12.16962 ? 1593 GLN A O    1 
ATOM   2089 C  CB   . GLN A 1 134 ? -19.41009 -0.97256  -6.87499  1.000 13.01447 ? 1593 GLN A CB   1 
ATOM   2090 C  CG   . GLN A 1 134 ? -20.30547 -1.32606  -8.02698  1.000 14.15159 ? 1593 GLN A CG   1 
ATOM   2091 C  CD   . GLN A 1 134 ? -21.56338 -0.45957  -8.02130  1.000 16.81488 ? 1593 GLN A CD   1 
ATOM   2092 O  OE1  . GLN A 1 134 ? -22.60402 -0.87099  -7.48768  1.000 18.51763 ? 1593 GLN A OE1  1 
ATOM   2093 N  NE2  . GLN A 1 134 ? -21.46969 0.70819   -8.56657  1.000 17.36762 ? 1593 GLN A NE2  1 
ATOM   2094 H  H    . GLN A 1 134 ? -18.04156 -3.45961  -7.69642  1.000 13.89922 ? 1593 GLN A H    1 
ATOM   2095 H  HA   . GLN A 1 134 ? -17.63422 -1.40837  -7.77939  1.000 14.36673 ? 1593 GLN A HA   1 
ATOM   2096 H  HB2  . GLN A 1 134 ? -19.85733 -1.24500  -6.05850  1.000 15.61736 ? 1593 GLN A HB2  1 
ATOM   2097 H  HB3  . GLN A 1 134 ? -19.28697 -0.01042  -6.88064  1.000 15.61736 ? 1593 GLN A HB3  1 
ATOM   2098 H  HG2  . GLN A 1 134 ? -19.83314 -1.17834  -8.86123  1.000 16.98191 ? 1593 GLN A HG2  1 
ATOM   2099 H  HG3  . GLN A 1 134 ? -20.57153 -2.25620  -7.95657  1.000 16.98191 ? 1593 GLN A HG3  1 
ATOM   2100 H  HE21 . GLN A 1 134 ? -20.72385 0.96377   -8.91008  1.000 20.84115 ? 1593 GLN A HE21 1 
ATOM   2101 H  HE22 . GLN A 1 134 ? -22.15318 1.22980   -8.58594  1.000 20.84115 ? 1593 GLN A HE22 1 
ATOM   2102 N  N    . GLN A 1 135 ? -17.38107 -0.29112  -4.97303  1.000 11.80144 ? 1594 GLN A N    1 
ATOM   2103 C  CA   . GLN A 1 135 ? -16.37544 0.14443   -4.01333  1.000 14.82285 ? 1594 GLN A CA   1 
ATOM   2104 C  C    . GLN A 1 135 ? -15.82975 -0.98402  -3.15043  1.000 11.77758 ? 1594 GLN A C    1 
ATOM   2105 O  O    . GLN A 1 135 ? -14.74762 -0.83909  -2.58620  1.000 11.77488 ? 1594 GLN A O    1 
ATOM   2106 C  CB   . GLN A 1 135 ? -16.87584 1.25715   -3.12161  1.000 27.45248 ? 1594 GLN A CB   1 
ATOM   2107 C  CG   . GLN A 1 135 ? -17.95502 0.85927   -2.22901  1.000 29.71099 ? 1594 GLN A CG   1 
ATOM   2108 C  CD   . GLN A 1 135 ? -18.51510 2.08593   -1.53785  1.000 30.01377 ? 1594 GLN A CD   1 
ATOM   2109 O  OE1  . GLN A 1 135 ? -18.05903 2.43206   -0.49311  1.000 29.07431 ? 1594 GLN A OE1  1 
ATOM   2110 N  NE2  . GLN A 1 135 ? -19.44564 2.79441   -2.22133  1.000 30.15864 ? 1594 GLN A NE2  1 
ATOM   2111 H  H    . GLN A 1 135 ? -18.15608 0.07536   -4.90481  1.000 14.16172 ? 1594 GLN A H    1 
ATOM   2112 H  HA   . GLN A 1 135 ? -15.64467 0.50424   -4.54003  1.000 17.78743 ? 1594 GLN A HA   1 
ATOM   2113 H  HB2  . GLN A 1 135 ? -16.13983 1.57124   -2.57341  1.000 32.94298 ? 1594 GLN A HB2  1 
ATOM   2114 H  HB3  . GLN A 1 135 ? -17.20524 1.97880   -3.67984  1.000 32.94298 ? 1594 GLN A HB3  1 
ATOM   2115 H  HG2  . GLN A 1 135 ? -18.66328 0.43490   -2.73811  1.000 35.65319 ? 1594 GLN A HG2  1 
ATOM   2116 H  HG3  . GLN A 1 135 ? -17.61698 0.24704   -1.55684  1.000 35.65319 ? 1594 GLN A HG3  1 
ATOM   2117 H  HE21 . GLN A 1 135 ? -19.68902 2.53997   -3.00595  1.000 36.19037 ? 1594 GLN A HE21 1 
ATOM   2118 H  HE22 . GLN A 1 135 ? -19.79302 3.49863   -1.87063  1.000 36.19037 ? 1594 GLN A HE22 1 
ATOM   2119 N  N    . THR A 1 136 ? -16.58354 -2.07838  -3.00768  1.000 10.85115 ? 1595 THR A N    1 
ATOM   2120 C  CA   . THR A 1 136 ? -16.13936 -3.19544  -2.18292  1.000 10.69046 ? 1595 THR A CA   1 
ATOM   2121 C  C    . THR A 1 136 ? -14.85003 -3.79549  -2.74412  1.000 9.84832  ? 1595 THR A C    1 
ATOM   2122 O  O    . THR A 1 136 ? -14.06370 -4.33397  -1.95967  1.000 10.11152 ? 1595 THR A O    1 
ATOM   2123 C  CB   . THR A 1 136 ? -17.24884 -4.25682  -2.07471  1.000 10.46947 ? 1595 THR A CB   1 
ATOM   2124 O  OG1  . THR A 1 136 ? -18.50624 -3.60881  -1.75395  1.000 10.82999 ? 1595 THR A OG1  1 
ATOM   2125 C  CG2  . THR A 1 136 ? -16.97320 -5.28531  -1.00403  1.000 11.17209 ? 1595 THR A CG2  1 
ATOM   2126 H  H    . THR A 1 136 ? -17.35138 -2.19555  -3.37687  1.000 13.02138 ? 1595 THR A H    1 
ATOM   2127 H  HA   . THR A 1 136 ? -15.96171 -2.88445  -1.28146  1.000 12.82856 ? 1595 THR A HA   1 
ATOM   2128 H  HB   . THR A 1 136 ? -17.29531 -4.71948  -2.92599  1.000 12.56337 ? 1595 THR A HB   1 
ATOM   2129 H  HG1  . THR A 1 136 ? -18.75151 -3.12441  -2.39489  1.000 12.99599 ? 1595 THR A HG1  1 
ATOM   2130 H  HG21 . THR A 1 136 ? -17.69853 -5.92830  -0.96707  1.000 13.40651 ? 1595 THR A HG21 1 
ATOM   2131 H  HG22 . THR A 1 136 ? -16.14667 -5.75401  -1.19915  1.000 13.40651 ? 1595 THR A HG22 1 
ATOM   2132 H  HG23 . THR A 1 136 ? -16.89273 -4.85153  -0.14017  1.000 13.40651 ? 1595 THR A HG23 1 
ATOM   2133 N  N    . VAL A 1 137 ? -14.63950 -3.69166  -4.04376  1.000 10.52205 ? 1596 VAL A N    1 
ATOM   2134 C  CA   A VAL A 1 137 ? -13.37546 -4.16755  -4.57888  0.339 9.88779  ? 1596 VAL A CA   1 
ATOM   2135 C  CA   B VAL A 1 137 ? -13.37102 -4.11490  -4.63515  0.661 9.94573  ? 1596 VAL A CA   1 
ATOM   2136 C  C    . VAL A 1 137 ? -12.22813 -3.34245  -4.02442  1.000 10.10357 ? 1596 VAL A C    1 
ATOM   2137 O  O    . VAL A 1 137 ? -11.20798 -3.88678  -3.60048  1.000 9.93254  ? 1596 VAL A O    1 
ATOM   2138 C  CB   A VAL A 1 137 ? -13.41076 -4.25697  -6.11022  0.339 9.96413  ? 1596 VAL A CB   1 
ATOM   2139 C  CB   B VAL A 1 137 ? -13.36535 -3.94978  -6.15874  0.661 11.36693 ? 1596 VAL A CB   1 
ATOM   2140 C  CG1  A VAL A 1 137 ? -13.22237 -2.91528  -6.73371  0.339 10.31938 ? 1596 VAL A CG1  1 
ATOM   2141 C  CG1  B VAL A 1 137 ? -11.92845 -4.23706  -6.71648  0.661 12.60912 ? 1596 VAL A CG1  1 
ATOM   2142 C  CG2  A VAL A 1 137 ? -12.36867 -5.26636  -6.60699  0.339 11.10900 ? 1596 VAL A CG2  1 
ATOM   2143 C  CG2  B VAL A 1 137 ? -14.39677 -4.82760  -6.78393  0.661 12.39594 ? 1596 VAL A CG2  1 
ATOM   2144 H  H    A VAL A 1 137 ? -15.18957 -3.36263  -4.61714  0.339 12.62646 ? 1596 VAL A H    1 
ATOM   2145 H  H    B VAL A 1 137 ? -15.20852 -3.38147  -4.60909  0.661 12.62646 ? 1596 VAL A H    1 
ATOM   2146 H  HA   A VAL A 1 137 ? -13.22983 -5.07840  -4.27881  0.339 11.86535 ? 1596 VAL A HA   1 
ATOM   2147 H  HA   B VAL A 1 137 ? -13.26653 -5.05897  -4.43840  0.661 11.93487 ? 1596 VAL A HA   1 
ATOM   2148 H  HB   A VAL A 1 137 ? -14.28484 -4.57332  -6.38736  0.339 11.95696 ? 1596 VAL A HB   1 
ATOM   2149 H  HB   B VAL A 1 137 ? -13.59486 -3.03697  -6.39326  0.661 13.64031 ? 1596 VAL A HB   1 
ATOM   2150 H  HG11 A VAL A 1 137 ? -13.60496 -2.92471  -7.62502  0.339 12.38326 ? 1596 VAL A HG11 1 
ATOM   2151 H  HG11 B VAL A 1 137 ? -11.98759 -4.40532  -7.66994  0.661 15.13095 ? 1596 VAL A HG11 1 
ATOM   2152 H  HG12 A VAL A 1 137 ? -13.66905 -2.24841  -6.18905  0.339 12.38326 ? 1596 VAL A HG12 1 
ATOM   2153 H  HG12 B VAL A 1 137 ? -11.36530 -3.46476  -6.55119  0.661 15.13095 ? 1596 VAL A HG12 1 
ATOM   2154 H  HG13 A VAL A 1 137 ? -12.27342 -2.72044  -6.78312  0.339 12.38326 ? 1596 VAL A HG13 1 
ATOM   2155 H  HG13 B VAL A 1 137 ? -11.56421 -5.01468  -6.26533  0.661 15.13095 ? 1596 VAL A HG13 1 
ATOM   2156 H  HG21 A VAL A 1 137 ? -12.37121 -5.27139  -7.57697  0.339 13.33079 ? 1596 VAL A HG21 1 
ATOM   2157 H  HG21 B VAL A 1 137 ? -14.42507 -4.65189  -7.73747  0.661 14.87513 ? 1596 VAL A HG21 1 
ATOM   2158 H  HG22 A VAL A 1 137 ? -11.49397 -5.00410  -6.27986  0.339 13.33079 ? 1596 VAL A HG22 1 
ATOM   2159 H  HG22 B VAL A 1 137 ? -14.16044 -5.75490  -6.62533  0.661 14.87513 ? 1596 VAL A HG22 1 
ATOM   2160 H  HG23 A VAL A 1 137 ? -12.59702 -6.14721  -6.27105  0.339 13.33079 ? 1596 VAL A HG23 1 
ATOM   2161 H  HG23 B VAL A 1 137 ? -15.25986 -4.63350  -6.38606  0.661 14.87513 ? 1596 VAL A HG23 1 
ATOM   2162 N  N    . ALA A 1 138 ? -12.37467 -2.01196  -3.96745  1.000 10.24572 ? 1597 ALA A N    1 
ATOM   2163 C  CA   . ALA A 1 138 ? -11.32651 -1.17589  -3.39315  1.000 10.39837 ? 1597 ALA A CA   1 
ATOM   2164 C  C    . ALA A 1 138 ? -11.15476 -1.46423  -1.91278  1.000 10.21945 ? 1597 ALA A C    1 
ATOM   2165 O  O    . ALA A 1 138 ? -10.03567 -1.52260  -1.39581  1.000 10.01409 ? 1597 ALA A O    1 
ATOM   2166 C  CB   . ALA A 1 138 ? -11.67404 0.29629   -3.62254  1.000 11.50373 ? 1597 ALA A CB   1 
ATOM   2167 H  H    . ALA A 1 138 ? -13.06194 -1.57971  -4.25103  1.000 12.29486 ? 1597 ALA A H    1 
ATOM   2168 H  HA   . ALA A 1 138 ? -10.48217 -1.36282  -3.83253  1.000 12.47805 ? 1597 ALA A HA   1 
ATOM   2169 H  HB1  . ALA A 1 138 ? -11.06941 0.84828   -3.10232  1.000 13.80447 ? 1597 ALA A HB1  1 
ATOM   2170 H  HB2  . ALA A 1 138 ? -11.57877 0.49995   -4.56613  1.000 13.80447 ? 1597 ALA A HB2  1 
ATOM   2171 H  HB3  . ALA A 1 138 ? -12.58915 0.45229   -3.34123  1.000 13.80447 ? 1597 ALA A HB3  1 
ATOM   2172 N  N    . ALA A 1 139 ? -12.26011 -1.64771  -1.18581  1.000 9.99829  ? 1598 ALA A N    1 
ATOM   2173 C  CA   . ALA A 1 139 ? -12.19743 -1.94524  0.22906   1.000 9.34566  ? 1598 ALA A CA   1 
ATOM   2174 C  C    . ALA A 1 139 ? -11.47877 -3.25730  0.52465   1.000 9.70088  ? 1598 ALA A C    1 
ATOM   2175 O  O    . ALA A 1 139 ? -10.64570 -3.30354  1.42075   1.000 10.29044 ? 1598 ALA A O    1 
ATOM   2176 C  CB   . ALA A 1 139 ? -13.59365 -1.96369  0.83085   1.000 10.55102 ? 1598 ALA A CB   1 
ATOM   2177 H  H    . ALA A 1 139 ? -13.06042 -1.60333  -1.49747  1.000 11.99795 ? 1598 ALA A H    1 
ATOM   2178 H  HA   . ALA A 1 139 ? -11.68739 -1.23468  0.64842   1.000 11.21479 ? 1598 ALA A HA   1 
ATOM   2179 H  HB1  . ALA A 1 139 ? -13.52823 -2.18122  1.77387   1.000 12.66123 ? 1598 ALA A HB1  1 
ATOM   2180 H  HB2  . ALA A 1 139 ? -13.99670 -1.08832  0.72049   1.000 12.66123 ? 1598 ALA A HB2  1 
ATOM   2181 H  HB3  . ALA A 1 139 ? -14.12599 -2.63304  0.37314   1.000 12.66123 ? 1598 ALA A HB3  1 
ATOM   2182 N  N    . VAL A 1 140 ? -11.78920 -4.32471  -0.22055  1.000 9.80358  ? 1599 VAL A N    1 
ATOM   2183 C  CA   . VAL A 1 140 ? -11.11390 -5.59118  0.07604   1.000 9.96669  ? 1599 VAL A CA   1 
ATOM   2184 C  C    . VAL A 1 140 ? -9.65371  -5.53453  -0.35591  1.000 9.35884  ? 1599 VAL A C    1 
ATOM   2185 O  O    . VAL A 1 140 ? -8.79747  -6.14079  0.28991   1.000 9.96935  ? 1599 VAL A O    1 
ATOM   2186 C  CB   . VAL A 1 140 ? -11.86433 -6.81452  -0.49398  1.000 9.93781  ? 1599 VAL A CB   1 
ATOM   2187 C  CG1  . VAL A 1 140 ? -11.71704 -6.94623  -1.99647  1.000 10.62207 ? 1599 VAL A CG1  1 
ATOM   2188 C  CG2  . VAL A 1 140 ? -11.41928 -8.09562  0.22634   1.000 10.82207 ? 1599 VAL A CG2  1 
ATOM   2189 H  H    . VAL A 1 140 ? -12.35568 -4.34084  -0.86742  1.000 11.76430 ? 1599 VAL A H    1 
ATOM   2190 H  HA   . VAL A 1 140 ? -11.13307 -5.71012  1.03853   1.000 11.96003 ? 1599 VAL A HA   1 
ATOM   2191 H  HB   . VAL A 1 140 ? -12.81119 -6.68102  -0.33109  1.000 11.92538 ? 1599 VAL A HB   1 
ATOM   2192 H  HG11 . VAL A 1 140 ? -12.31408 -7.64234  -2.31250  1.000 12.74649 ? 1599 VAL A HG11 1 
ATOM   2193 H  HG12 . VAL A 1 140 ? -11.94640 -6.10011  -2.41165  1.000 12.74649 ? 1599 VAL A HG12 1 
ATOM   2194 H  HG13 . VAL A 1 140 ? -10.79856 -7.17859  -2.20459  1.000 12.74649 ? 1599 VAL A HG13 1 
ATOM   2195 H  HG21 . VAL A 1 140 ? -11.89441 -8.85194  -0.15199  1.000 12.98649 ? 1599 VAL A HG21 1 
ATOM   2196 H  HG22 . VAL A 1 140 ? -10.46386 -8.21070  0.10460   1.000 12.98649 ? 1599 VAL A HG22 1 
ATOM   2197 H  HG23 . VAL A 1 140 ? -11.62501 -8.01459  1.17080   1.000 12.98649 ? 1599 VAL A HG23 1 
ATOM   2198 N  N    . LEU A 1 141 ? -9.34669  -4.78895  -1.41055  1.000 9.02718  ? 1600 LEU A N    1 
ATOM   2199 C  CA   . LEU A 1 141 ? -7.94369  -4.57612  -1.77622  1.000 9.05351  ? 1600 LEU A CA   1 
ATOM   2200 C  C    . LEU A 1 141 ? -7.19940  -3.87842  -0.65418  1.000 9.64571  ? 1600 LEU A C    1 
ATOM   2201 O  O    . LEU A 1 141 ? -6.04839  -4.21100  -0.36953  1.000 10.52733 ? 1600 LEU A O    1 
ATOM   2202 C  CB   . LEU A 1 141 ? -7.86026  -3.80745  -3.04884  1.000 10.15628 ? 1600 LEU A CB   1 
ATOM   2203 C  CG   . LEU A 1 141 ? -7.97669  -4.56731  -4.35248  1.000 14.03042 ? 1600 LEU A CG   1 
ATOM   2204 C  CD1  . LEU A 1 141 ? -8.05787  -3.69600  -5.57391  1.000 14.69353 ? 1600 LEU A CD1  1 
ATOM   2205 C  CD2  . LEU A 1 141 ? -6.74809  -5.51016  -4.50638  1.000 18.29394 ? 1600 LEU A CD2  1 
ATOM   2206 H  H    . LEU A 1 141 ? -9.91669  -4.40050  -1.92417  1.000 10.83262 ? 1600 LEU A H    1 
ATOM   2207 H  HA   . LEU A 1 141 ? -7.51348  -5.43190  -1.92947  1.000 10.86421 ? 1600 LEU A HA   1 
ATOM   2208 H  HB2  . LEU A 1 141 ? -8.57617  -3.15297  -3.04409  1.000 12.18753 ? 1600 LEU A HB2  1 
ATOM   2209 H  HB3  . LEU A 1 141 ? -7.00051  -3.35858  -3.06499  1.000 12.18753 ? 1600 LEU A HB3  1 
ATOM   2210 H  HG   . LEU A 1 141 ? -8.81063  -5.06090  -4.30978  1.000 16.83650 ? 1600 LEU A HG   1 
ATOM   2211 H  HD11 . LEU A 1 141 ? -8.13671  -4.25975  -6.35931  1.000 17.63224 ? 1600 LEU A HD11 1 
ATOM   2212 H  HD12 . LEU A 1 141 ? -8.83536  -3.12067  -5.50031  1.000 17.63224 ? 1600 LEU A HD12 1 
ATOM   2213 H  HD13 . LEU A 1 141 ? -7.25273  -3.15818  -5.63225  1.000 17.63224 ? 1600 LEU A HD13 1 
ATOM   2214 H  HD21 . LEU A 1 141 ? -6.70022  -5.81918  -5.42459  1.000 21.95273 ? 1600 LEU A HD21 1 
ATOM   2215 H  HD22 . LEU A 1 141 ? -5.94279  -5.01897  -4.28027  1.000 21.95273 ? 1600 LEU A HD22 1 
ATOM   2216 H  HD23 . LEU A 1 141 ? -6.85335  -6.26628  -3.90796  1.000 21.95273 ? 1600 LEU A HD23 1 
ATOM   2217 N  N    A MET A 1 142 ? -7.83179  -2.91616  -0.00212  0.825 9.85620  ? 1601 MET A N    1 
ATOM   2218 N  N    B MET A 1 142 ? -7.83711  -2.92048  -0.00524  0.175 10.92211 ? 1601 MET A N    1 
ATOM   2219 C  CA   A MET A 1 142 ? -7.16803  -2.26786  1.12222   0.825 9.72992  ? 1601 MET A CA   1 
ATOM   2220 C  CA   B MET A 1 142 ? -7.18637  -2.24789  1.10660   0.175 11.98013 ? 1601 MET A CA   1 
ATOM   2221 C  C    A MET A 1 142 ? -6.88199  -3.26370  2.23038   0.825 9.17724  ? 1601 MET A C    1 
ATOM   2222 C  C    B MET A 1 142 ? -6.90951  -3.21917  2.25212   0.175 10.77210 ? 1601 MET A C    1 
ATOM   2223 O  O    A MET A 1 142 ? -5.79380  -3.27363  2.80620   0.825 9.99568  ? 1601 MET A O    1 
ATOM   2224 O  O    B MET A 1 142 ? -5.83693  -3.17854  2.86629   0.175 10.96948 ? 1601 MET A O    1 
ATOM   2225 C  CB   A MET A 1 142 ? -8.02979  -1.10302  1.65332   0.825 10.56152 ? 1601 MET A CB   1 
ATOM   2226 C  CB   B MET A 1 142 ? -8.06790  -1.08060  1.54883   0.175 13.83296 ? 1601 MET A CB   1 
ATOM   2227 C  CG   A MET A 1 142 ? -7.34822  -0.24949  2.67196   0.825 10.75108 ? 1601 MET A CG   1 
ATOM   2228 C  CG   B MET A 1 142 ? -7.44239  -0.27554  2.61260   0.175 14.42513 ? 1601 MET A CG   1 
ATOM   2229 S  SD   A MET A 1 142 ? -5.95451  0.73843   1.95293   0.825 12.98288 ? 1601 MET A SD   1 
ATOM   2230 S  SD   B MET A 1 142 ? -7.92787  -0.69396  4.28225   0.175 13.53830 ? 1601 MET A SD   1 
ATOM   2231 C  CE   A MET A 1 142 ? -4.54202  -0.10836  2.58736   0.825 15.44096 ? 1601 MET A CE   1 
ATOM   2232 C  CE   B MET A 1 142 ? -9.04210  -2.04722  4.32170   0.175 16.87537 ? 1601 MET A CE   1 
ATOM   2233 H  H    A MET A 1 142 ? -8.62120  -2.62631  -0.18217  0.825 11.82744 ? 1601 MET A H    1 
ATOM   2234 H  H    B MET A 1 142 ? -8.63191  -2.64448  -0.18331  0.175 13.10653 ? 1601 MET A H    1 
ATOM   2235 H  HA   A MET A 1 142 ? -6.32963  -1.89312  0.80991   0.825 11.67591 ? 1601 MET A HA   1 
ATOM   2236 H  HA   B MET A 1 142 ? -6.33203  -1.88593  0.82376   0.175 14.37615 ? 1601 MET A HA   1 
ATOM   2237 H  HB2  A MET A 1 142 ? -8.27327  -0.53270  0.90743   0.825 12.67382 ? 1601 MET A HB2  1 
ATOM   2238 H  HB2  B MET A 1 142 ? -8.23145  -0.50107  0.78837   0.175 16.59955 ? 1601 MET A HB2  1 
ATOM   2239 H  HB3  A MET A 1 142 ? -8.82789  -1.47048  2.06431   0.825 12.67382 ? 1601 MET A HB3  1 
ATOM   2240 H  HB3  B MET A 1 142 ? -8.90768  -1.42824  1.88769   0.175 16.59955 ? 1601 MET A HB3  1 
ATOM   2241 H  HG2  A MET A 1 142 ? -7.99270  0.36962   3.04913   0.825 12.90130 ? 1601 MET A HG2  1 
ATOM   2242 H  HG2  B MET A 1 142 ? -6.48067  -0.38832  2.55538   0.175 17.31016 ? 1601 MET A HG2  1 
ATOM   2243 H  HG3  A MET A 1 142 ? -6.98584  -0.81728  3.36996   0.825 12.90130 ? 1601 MET A HG3  1 
ATOM   2244 H  HG3  B MET A 1 142 ? -7.67645  0.65479   2.46908   0.175 17.31016 ? 1601 MET A HG3  1 
ATOM   2245 H  HE1  A MET A 1 142 ? -3.74015  0.29824   2.22327   0.825 18.52915 ? 1601 MET A HE1  1 
ATOM   2246 H  HE1  B MET A 1 142 ? -9.75511  -1.85103  4.94942   0.175 20.25045 ? 1601 MET A HE1  1 
ATOM   2247 H  HE2  A MET A 1 142 ? -4.53913  -0.03695  3.55472   0.825 18.52915 ? 1601 MET A HE2  1 
ATOM   2248 H  HE2  B MET A 1 142 ? -9.41001  -2.17935  3.43396   0.175 20.25045 ? 1601 MET A HE2  1 
ATOM   2249 H  HE3  A MET A 1 142 ? -4.58854  -1.04095  2.32466   0.825 18.52915 ? 1601 MET A HE3  1 
ATOM   2250 H  HE3  B MET A 1 142 ? -8.56323  -2.84248  4.60304   0.175 20.25045 ? 1601 MET A HE3  1 
ATOM   2251 N  N    . VAL A 1 143 ? -7.86093  -4.10542  2.55085   1.000 9.61408  ? 1602 VAL A N    1 
ATOM   2252 C  CA   . VAL A 1 143 ? -7.63740  -5.10976  3.58309   1.000 10.16938 ? 1602 VAL A CA   1 
ATOM   2253 C  C    . VAL A 1 143 ? -6.49767  -6.06019  3.20173   1.000 9.50092  ? 1602 VAL A C    1 
ATOM   2254 O  O    . VAL A 1 143 ? -5.63899  -6.38259  4.04143   1.000 10.40889 ? 1602 VAL A O    1 
ATOM   2255 C  CB   . VAL A 1 143 ? -8.95496  -5.87494  3.87251   1.000 11.20903 ? 1602 VAL A CB   1 
ATOM   2256 C  CG1  . VAL A 1 143 ? -8.70269  -7.13250  4.70195   1.000 11.70904 ? 1602 VAL A CG1  1 
ATOM   2257 C  CG2  . VAL A 1 143 ? -9.94006  -4.95193  4.61703   1.000 12.33800 ? 1602 VAL A CG2  1 
ATOM   2258 H  H    . VAL A 1 143 ? -8.64284  -4.11316  2.19284   1.000 11.53689 ? 1602 VAL A H    1 
ATOM   2259 H  HA   . VAL A 1 143 ? -7.36474  -4.65311  4.39428   1.000 12.20325 ? 1602 VAL A HA   1 
ATOM   2260 H  HB   . VAL A 1 143 ? -9.34037  -6.14987  3.02588   1.000 13.45084 ? 1602 VAL A HB   1 
ATOM   2261 H  HG11 . VAL A 1 143 ? -9.54513  -7.44283  5.06923   1.000 14.05084 ? 1602 VAL A HG11 1 
ATOM   2262 H  HG12 . VAL A 1 143 ? -8.31917  -7.81606  4.13050   1.000 14.05084 ? 1602 VAL A HG12 1 
ATOM   2263 H  HG13 . VAL A 1 143 ? -8.08730  -6.91863  5.42060   1.000 14.05084 ? 1602 VAL A HG13 1 
ATOM   2264 H  HG21 . VAL A 1 143 ? -10.68789 -5.48052  4.93678   1.000 14.80561 ? 1602 VAL A HG21 1 
ATOM   2265 H  HG22 . VAL A 1 143 ? -9.48197  -4.53985  5.36620   1.000 14.80561 ? 1602 VAL A HG22 1 
ATOM   2266 H  HG23 . VAL A 1 143 ? -10.25570 -4.26819  4.00567   1.000 14.80561 ? 1602 VAL A HG23 1 
ATOM   2267 N  N    . ALA A 1 144 ? -6.44436  -6.44098  1.93912   1.000 10.26418 ? 1603 ALA A N    1 
ATOM   2268 C  CA   . ALA A 1 144 ? -5.34754  -7.31146  1.49024   1.000 10.86419 ? 1603 ALA A CA   1 
ATOM   2269 C  C    . ALA A 1 144 ? -4.00215  -6.62703  1.66536   1.000 10.70892 ? 1603 ALA A C    1 
ATOM   2270 O  O    . ALA A 1 144 ? -3.02160  -7.26671  2.05045   1.000 10.34045 ? 1603 ALA A O    1 
ATOM   2271 C  CB   . ALA A 1 144 ? -5.59831  -7.74504  0.05738   1.000 11.42479 ? 1603 ALA A CB   1 
ATOM   2272 H  H    . ALA A 1 144 ? -7.00990  -6.22159  1.32951   1.000 12.31702 ? 1603 ALA A H    1 
ATOM   2273 H  HA   . ALA A 1 144 ? -5.32064  -8.11765  2.02898   1.000 13.03703 ? 1603 ALA A HA   1 
ATOM   2274 H  HB1  . ALA A 1 144 ? -4.87087  -8.31824  -0.23102  1.000 13.70975 ? 1603 ALA A HB1  1 
ATOM   2275 H  HB2  . ALA A 1 144 ? -6.43754  -8.22970  0.01637   1.000 13.70975 ? 1603 ALA A HB2  1 
ATOM   2276 H  HB3  . ALA A 1 144 ? -5.64303  -6.95779  -0.50755  1.000 13.70975 ? 1603 ALA A HB3  1 
ATOM   2277 N  N    . GLN A 1 145 ? -3.93225  -5.32247  1.39529   1.000 11.05641 ? 1604 GLN A N    1 
ATOM   2278 C  CA   . GLN A 1 145 ? -2.65171  -4.63937  1.57506   1.000 11.56432 ? 1604 GLN A CA   1 
ATOM   2279 C  C    . GLN A 1 145 ? -2.28186  -4.51048  3.03700   1.000 11.85383 ? 1604 GLN A C    1 
ATOM   2280 O  O    . GLN A 1 145 ? -1.10078  -4.62290  3.39277   1.000 11.71167 ? 1604 GLN A O    1 
ATOM   2281 C  CB   . GLN A 1 145 ? -2.64366  -3.25092  0.92032   1.000 12.51972 ? 1604 GLN A CB   1 
ATOM   2282 C  CG   . GLN A 1 145 ? -3.07288  -3.19944  -0.51260  1.000 14.67254 ? 1604 GLN A CG   1 
ATOM   2283 C  CD   . GLN A 1 145 ? -2.68704  -4.36497  -1.39123  1.000 15.48314 ? 1604 GLN A CD   1 
ATOM   2284 O  OE1  . GLN A 1 145 ? -1.49916  -4.71126  -1.54284  1.000 16.22008 ? 1604 GLN A OE1  1 
ATOM   2285 N  NE2  . GLN A 1 145 ? -3.71343  -5.05542  -1.90380  1.000 14.54626 ? 1604 GLN A NE2  1 
ATOM   2286 H  H    . GLN A 1 145 ? -4.58213  -4.83160  1.11907   1.000 13.26769 ? 1604 GLN A H    1 
ATOM   2287 H  HA   . GLN A 1 145 ? -1.98346  -5.18015  1.12572   1.000 13.87719 ? 1604 GLN A HA   1 
ATOM   2288 H  HB2  . GLN A 1 145 ? -3.24443  -2.67648  1.42031   1.000 15.02366 ? 1604 GLN A HB2  1 
ATOM   2289 H  HB3  . GLN A 1 145 ? -1.73969  -2.90157  0.96149   1.000 15.02366 ? 1604 GLN A HB3  1 
ATOM   2290 H  HG2  . GLN A 1 145 ? -4.04093  -3.14117  -0.53263  1.000 17.60705 ? 1604 GLN A HG2  1 
ATOM   2291 H  HG3  . GLN A 1 145 ? -2.68440  -2.40570  -0.91254  1.000 17.60705 ? 1604 GLN A HG3  1 
ATOM   2292 H  HE21 . GLN A 1 145 ? -4.52133  -4.82226  -1.72343  1.000 17.45551 ? 1604 GLN A HE21 1 
ATOM   2293 H  HE22 . GLN A 1 145 ? -3.56476  -5.73204  -2.41339  1.000 17.45551 ? 1604 GLN A HE22 1 
ATOM   2294 N  N    . LEU A 1 146 ? -3.25424  -4.22313  3.90521   1.000 12.57754 ? 1605 LEU A N    1 
ATOM   2295 C  CA   . LEU A 1 146 ? -2.97778  -4.04670  5.31530   1.000 12.98025 ? 1605 LEU A CA   1 
ATOM   2296 C  C    . LEU A 1 146 ? -2.41565  -5.32395  5.87686   1.000 13.89622 ? 1605 LEU A C    1 
ATOM   2297 O  O    . LEU A 1 146 ? -1.59422  -5.31773  6.79914   1.000 15.32260 ? 1605 LEU A O    1 
ATOM   2298 C  CB   . LEU A 1 146 ? -4.26529  -3.62242  6.07797   1.000 13.38821 ? 1605 LEU A CB   1 
ATOM   2299 C  CG   . LEU A 1 146 ? -4.69372  -2.18716  5.78712   1.000 14.13574 ? 1605 LEU A CG   1 
ATOM   2300 C  CD1  . LEU A 1 146 ? -6.07924  -1.99880  6.37755   1.000 14.32513 ? 1605 LEU A CD1  1 
ATOM   2301 C  CD2  . LEU A 1 146 ? -3.70982  -1.17121  6.35661   1.000 16.06741 ? 1605 LEU A CD2  1 
ATOM   2302 H  H    . LEU A 1 146 ? -4.08267  -4.12618  3.69571   1.000 15.09305 ? 1605 LEU A H    1 
ATOM   2303 H  HA   . LEU A 1 146 ? -2.33574  -3.33074  5.44211   1.000 15.57630 ? 1605 LEU A HA   1 
ATOM   2304 H  HB2  . LEU A 1 146 ? -4.99168  -4.20977  5.81667   1.000 16.06585 ? 1605 LEU A HB2  1 
ATOM   2305 H  HB3  . LEU A 1 146 ? -4.10367  -3.69854  7.03137   1.000 16.06585 ? 1605 LEU A HB3  1 
ATOM   2306 H  HG   . LEU A 1 146 ? -4.70988  -2.02715  4.83054   1.000 16.96289 ? 1605 LEU A HG   1 
ATOM   2307 H  HD11 . LEU A 1 146 ? -6.36637  -1.08507  6.22407   1.000 17.19015 ? 1605 LEU A HD11 1 
ATOM   2308 H  HD12 . LEU A 1 146 ? -6.69240  -2.61493  5.94708   1.000 17.19015 ? 1605 LEU A HD12 1 
ATOM   2309 H  HD13 . LEU A 1 146 ? -6.04377  -2.17881  7.33004   1.000 17.19015 ? 1605 LEU A HD13 1 
ATOM   2310 H  HD21 . LEU A 1 146 ? -4.03734  -0.27692  6.17253   1.000 19.28089 ? 1605 LEU A HD21 1 
ATOM   2311 H  HD22 . LEU A 1 146 ? -3.63589  -1.30577  7.31438   1.000 19.28089 ? 1605 LEU A HD22 1 
ATOM   2312 H  HD23 . LEU A 1 146 ? -2.84486  -1.29963  5.93679   1.000 19.28089 ? 1605 LEU A HD23 1 
ATOM   2313 N  N    . THR A 1 147 ? -2.88905  -6.45548  5.35458   1.000 14.77520 ? 1606 THR A N    1 
ATOM   2314 C  CA   . THR A 1 147 ? -2.46299  -7.77617  5.81811   1.000 15.31211 ? 1606 THR A CA   1 
ATOM   2315 C  C    . THR A 1 147 ? -1.37846  -8.40465  4.94612   1.000 16.14909 ? 1606 THR A C    1 
ATOM   2316 O  O    . THR A 1 147 ? -0.99442  -9.56029  5.20512   1.000 17.83079 ? 1606 THR A O    1 
ATOM   2317 C  CB   . THR A 1 147 ? -3.69915  -8.67997  5.95065   1.000 14.92264 ? 1606 THR A CB   1 
ATOM   2318 O  OG1  . THR A 1 147 ? -4.36598  -8.87820  4.70389   1.000 14.28569 ? 1606 THR A OG1  1 
ATOM   2319 C  CG2  . THR A 1 147 ? -4.70741  -8.13154  6.91658   1.000 16.47013 ? 1606 THR A CG2  1 
ATOM   2320 H  H    . THR A 1 147 ? -3.46816  -6.48458  4.71946   1.000 17.73024 ? 1606 THR A H    1 
ATOM   2321 H  HA   . THR A 1 147 ? -2.06697  -7.70552  6.70076   1.000 18.37453 ? 1606 THR A HA   1 
ATOM   2322 H  HB   . THR A 1 147 ? -3.36636  -9.52995  6.27880   1.000 17.90717 ? 1606 THR A HB   1 
ATOM   2323 H  HG1  . THR A 1 147 ? -4.63682  -8.14229  4.40275   1.000 17.14283 ? 1606 THR A HG1  1 
ATOM   2324 H  HG21 . THR A 1 147 ? -5.45089  -8.74812  7.00583   1.000 19.76415 ? 1606 THR A HG21 1 
ATOM   2325 H  HG22 . THR A 1 147 ? -4.29806  -8.00396  7.78667   1.000 19.76415 ? 1606 THR A HG22 1 
ATOM   2326 H  HG23 . THR A 1 147 ? -5.04223  -7.27868  6.59810   1.000 19.76415 ? 1606 THR A HG23 1 
ATOM   2327 N  N    . GLN A 1 148 ? -0.89634  -7.66012  3.92834   1.000 16.02801 ? 1607 GLN A N    1 
ATOM   2328 C  CA   . GLN A 1 148 ? 0.26317   -7.99927  3.09911   1.000 15.91756 ? 1607 GLN A CA   1 
ATOM   2329 C  C    . GLN A 1 148 ? 0.09886   -9.31335  2.32524   1.000 15.31473 ? 1607 GLN A C    1 
ATOM   2330 O  O    . GLN A 1 148 ? 0.97096   -10.19504 2.34676   1.000 17.19649 ? 1607 GLN A O    1 
ATOM   2331 C  CB   . GLN A 1 148 ? 1.58157   -7.99537  3.89778   1.000 19.02844 ? 1607 GLN A CB   1 
ATOM   2332 C  CG   . GLN A 1 148 ? 1.82401   -6.74595  4.68860   1.000 23.03673 ? 1607 GLN A CG   1 
ATOM   2333 C  CD   . GLN A 1 148 ? 3.04903   -6.91046  5.62965   1.000 27.27410 ? 1607 GLN A CD   1 
ATOM   2334 O  OE1  . GLN A 1 148 ? 4.17741   -6.83993  5.17883   1.000 31.48493 ? 1607 GLN A OE1  1 
ATOM   2335 N  NE2  . GLN A 1 148 ? 2.80660   -7.17374  6.91809   1.000 29.77950 ? 1607 GLN A NE2  1 
ATOM   2336 H  H    . GLN A 1 148 ? -1.24934  -6.91263  3.69117   1.000 19.23361 ? 1607 GLN A H    1 
ATOM   2337 H  HA   . GLN A 1 148 ? 0.31656   -7.29608  2.43309   1.000 19.10108 ? 1607 GLN A HA   1 
ATOM   2338 H  HB2  . GLN A 1 148 ? 1.56769   -8.73865  4.52087   1.000 22.83413 ? 1607 GLN A HB2  1 
ATOM   2339 H  HB3  . GLN A 1 148 ? 2.31958   -8.09696  3.27656   1.000 22.83413 ? 1607 GLN A HB3  1 
ATOM   2340 H  HG2  . GLN A 1 148 ? 1.99908   -6.00923  4.08238   1.000 27.64408 ? 1607 GLN A HG2  1 
ATOM   2341 H  HG3  . GLN A 1 148 ? 1.04389   -6.55097  5.23110   1.000 27.64408 ? 1607 GLN A HG3  1 
ATOM   2342 H  HE21 . GLN A 1 148 ? 1.99635   -7.24579  7.19720   1.000 35.73540 ? 1607 GLN A HE21 1 
ATOM   2343 H  HE22 . GLN A 1 148 ? 3.46094   -7.27102  7.46761   1.000 35.73540 ? 1607 GLN A HE22 1 
ATOM   2344 N  N    . ARG A 1 149 ? -1.03417  -9.49219  1.67706   1.000 11.74339 ? 1608 ARG A N    1 
ATOM   2345 C  CA   . ARG A 1 149 ? -1.24433  -10.70831 0.88732   1.000 11.09320 ? 1608 ARG A CA   1 
ATOM   2346 C  C    . ARG A 1 149 ? -2.11753  -10.44636 -0.33754  1.000 10.62738 ? 1608 ARG A C    1 
ATOM   2347 O  O    . ARG A 1 149 ? -2.57532  -9.32650  -0.58507  1.000 11.15634 ? 1608 ARG A O    1 
ATOM   2348 C  CB   . ARG A 1 149 ? -1.81667  -11.81137 1.79547   1.000 11.15373 ? 1608 ARG A CB   1 
ATOM   2349 C  CG   . ARG A 1 149 ? -3.25230  -11.59704 2.28261   1.000 11.28268 ? 1608 ARG A CG   1 
ATOM   2350 C  CD   . ARG A 1 149 ? -3.94958  -12.91909 2.53128   1.000 11.41689 ? 1608 ARG A CD   1 
ATOM   2351 N  NE   . ARG A 1 149 ? -4.24122  -13.54490 1.25312   1.000 11.82484 ? 1608 ARG A NE   1 
ATOM   2352 C  CZ   . ARG A 1 149 ? -4.32529  -14.84985 1.04298   1.000 11.31954 ? 1608 ARG A CZ   1 
ATOM   2353 N  NH1  . ARG A 1 149 ? -4.24294  -15.71383 2.04749   1.000 11.83012 ? 1608 ARG A NH1  1 
ATOM   2354 N  NH2  . ARG A 1 149 ? -4.49541  -15.28440 -0.20278  1.000 11.81170 ? 1608 ARG A NH2  1 
ATOM   2355 H  H    . ARG A 1 149 ? -1.69172  -8.93792  1.67333   1.000 14.09207 ? 1608 ARG A H    1 
ATOM   2356 H  HA   . ARG A 1 149 ? -0.38971  -10.98785 0.52349   1.000 13.31184 ? 1608 ARG A HA   1 
ATOM   2357 H  HB2  . ARG A 1 149 ? -1.80207  -12.64740 1.30381   1.000 13.38448 ? 1608 ARG A HB2  1 
ATOM   2358 H  HB3  . ARG A 1 149 ? -1.25357  -11.87937 2.58236   1.000 13.38448 ? 1608 ARG A HB3  1 
ATOM   2359 H  HG2  . ARG A 1 149 ? -3.23957  -11.09663 3.11347   1.000 13.53921 ? 1608 ARG A HG2  1 
ATOM   2360 H  HG3  . ARG A 1 149 ? -3.75190  -11.10935 1.60922   1.000 13.53921 ? 1608 ARG A HG3  1 
ATOM   2361 H  HD2  . ARG A 1 149 ? -3.37334  -13.50552 3.04601   1.000 13.70027 ? 1608 ARG A HD2  1 
ATOM   2362 H  HD3  . ARG A 1 149 ? -4.78155  -12.77008 3.00724   1.000 13.70027 ? 1608 ARG A HD3  1 
ATOM   2363 H  HE   . ARG A 1 149 ? -4.36955  -13.02657 0.57898   1.000 14.18981 ? 1608 ARG A HE   1 
ATOM   2364 H  HH11 . ARG A 1 149 ? -4.13310  -15.42921 2.85155   1.000 14.19615 ? 1608 ARG A HH11 1 
ATOM   2365 H  HH12 . ARG A 1 149 ? -4.29942  -16.55816 1.89417   1.000 14.19615 ? 1608 ARG A HH12 1 
ATOM   2366 H  HH21 . ARG A 1 149 ? -4.54847  -14.72172 -0.85099  1.000 14.17405 ? 1608 ARG A HH21 1 
ATOM   2367 H  HH22 . ARG A 1 149 ? -4.55233  -16.12800 -0.35992  1.000 14.17405 ? 1608 ARG A HH22 1 
ATOM   2368 N  N    . SER A 1 150 ? -2.36216  -11.49869 -1.11113  1.000 10.53520 ? 1609 SER A N    1 
ATOM   2369 C  CA   . SER A 1 150 ? -3.11959  -11.44861 -2.34202  1.000 10.46948 ? 1609 SER A CA   1 
ATOM   2370 C  C    . SER A 1 150 ? -4.61840  -11.58909 -2.11262  1.000 10.04312 ? 1609 SER A C    1 
ATOM   2371 O  O    . SER A 1 150 ? -5.07534  -12.04421 -1.06450  1.000 10.39571 ? 1609 SER A O    1 
ATOM   2372 C  CB   . SER A 1 150 ? -2.63511  -12.49486 -3.30903  1.000 10.85367 ? 1609 SER A CB   1 
ATOM   2373 O  OG   . SER A 1 150 ? -2.92460  -13.80089 -2.78899  1.000 12.93283 ? 1609 SER A OG   1 
ATOM   2374 H  H    . SER A 1 150 ? -2.08294  -12.29167 -0.92996  1.000 12.64224 ? 1609 SER A H    1 
ATOM   2375 H  HA   . SER A 1 150 ? -2.98274  -10.57522 -2.74123  1.000 12.56337 ? 1609 SER A HA   1 
ATOM   2376 H  HB2  . SER A 1 150 ? -3.08805  -12.38036 -4.15911  1.000 13.02440 ? 1609 SER A HB2  1 
ATOM   2377 H  HB3  . SER A 1 150 ? -1.67697  -12.40221 -3.42850  1.000 13.02440 ? 1609 SER A HB3  1 
ATOM   2378 H  HG   . SER A 1 150 ? -2.44112  -14.37435 -3.16714  1.000 15.51940 ? 1609 SER A HG   1 
ATOM   2379 N  N    . VAL A 1 151 ? -5.36794  -11.22323 -3.14562  1.000 9.31932  ? 1610 VAL A N    1 
ATOM   2380 C  CA   . VAL A 1 151 ? -6.80142  -11.48566 -3.17368  1.000 9.16928  ? 1610 VAL A CA   1 
ATOM   2381 C  C    . VAL A 1 151 ? -7.20174  -11.68671 -4.61839  1.000 9.27719  ? 1610 VAL A C    1 
ATOM   2382 O  O    . VAL A 1 151 ? -6.63433  -11.10062 -5.55900  1.000 9.92198  ? 1610 VAL A O    1 
ATOM   2383 C  CB   . VAL A 1 151 ? -7.59779  -10.36160 -2.48849  1.000 9.76148  ? 1610 VAL A CB   1 
ATOM   2384 C  CG1  . VAL A 1 151 ? -7.48247  -9.03624  -3.17259  1.000 11.42214 ? 1610 VAL A CG1  1 
ATOM   2385 C  CG2  . VAL A 1 151 ? -9.10447  -10.78411 -2.36240  1.000 11.37211 ? 1610 VAL A CG2  1 
ATOM   2386 H  H    . VAL A 1 151 ? -5.06879  -10.82049 -3.84412  1.000 11.18319 ? 1610 VAL A H    1 
ATOM   2387 H  HA   . VAL A 1 151 ? -7.00180  -12.30521 -2.69505  1.000 11.00313 ? 1610 VAL A HA   1 
ATOM   2388 H  HB   . VAL A 1 151 ? -7.21194  -10.23486 -1.60760  1.000 11.71378 ? 1610 VAL A HB   1 
ATOM   2389 H  HG11 . VAL A 1 151 ? -7.93468  -8.36469  -2.63834  1.000 13.70656 ? 1610 VAL A HG11 1 
ATOM   2390 H  HG12 . VAL A 1 151 ? -6.54398  -8.80891  -3.26453  1.000 13.70656 ? 1610 VAL A HG12 1 
ATOM   2391 H  HG13 . VAL A 1 151 ? -7.89571  -9.09576  -4.04814  1.000 13.70656 ? 1610 VAL A HG13 1 
ATOM   2392 H  HG21 . VAL A 1 151 ? -9.58154  -10.10600 -1.85894  1.000 13.64654 ? 1610 VAL A HG21 1 
ATOM   2393 H  HG22 . VAL A 1 151 ? -9.48508  -10.86537 -3.25090  1.000 13.64654 ? 1610 VAL A HG22 1 
ATOM   2394 H  HG23 . VAL A 1 151 ? -9.15606  -11.63593 -1.90127  1.000 13.64654 ? 1610 VAL A HG23 1 
ATOM   2395 N  N    . HIS A 1 152 ? -8.23194  -12.53112 -4.83408  1.000 9.09033  ? 1611 HIS A N    1 
ATOM   2396 C  CA   . HIS A 1 152 ? -8.82696  -12.76468 -6.13172  1.000 9.17718  ? 1611 HIS A CA   1 
ATOM   2397 C  C    . HIS A 1 152 ? -10.26795 -12.26120 -6.11492  1.000 8.60874  ? 1611 HIS A C    1 
ATOM   2398 O  O    . HIS A 1 152 ? -11.02523 -12.62611 -5.19928  1.000 9.64297  ? 1611 HIS A O    1 
ATOM   2399 C  CB   . HIS A 1 152 ? -8.78414  -14.25923 -6.43702  1.000 8.97709  ? 1611 HIS A CB   1 
ATOM   2400 C  CG   . HIS A 1 152 ? -9.41342  -14.61824 -7.73351  1.000 8.35869  ? 1611 HIS A CG   1 
ATOM   2401 N  ND1  . HIS A 1 152 ? -8.75847  -14.53868 -8.93759  1.000 9.00081  ? 1611 HIS A ND1  1 
ATOM   2402 C  CD2  . HIS A 1 152 ? -10.65340 -15.12193 -8.02132  1.000 7.90078  ? 1611 HIS A CD2  1 
ATOM   2403 C  CE1  . HIS A 1 152 ? -9.53677  -15.00639 -9.89958  1.000 9.42982  ? 1611 HIS A CE1  1 
ATOM   2404 N  NE2  . HIS A 1 152 ? -10.71575 -15.34668 -9.36466  1.000 9.38505  ? 1611 HIS A NE2  1 
ATOM   2405 H  H    . HIS A 1 152 ? -8.60522  -12.98937 -4.20936  1.000 10.90840 ? 1611 HIS A H    1 
ATOM   2406 H  HA   . HIS A 1 152 ? -8.35259  -12.28240 -6.82691  1.000 11.01261 ? 1611 HIS A HA   1 
ATOM   2407 H  HB2  . HIS A 1 152 ? -7.85793  -14.54583 -6.46705  1.000 10.77251 ? 1611 HIS A HB2  1 
ATOM   2408 H  HB3  . HIS A 1 152 ? -9.25615  -14.73524 -5.73594  1.000 10.77251 ? 1611 HIS A HB3  1 
ATOM   2409 H  HD2  . HIS A 1 152 ? -11.33389 -15.28262 -7.40812  1.000 9.48093  ? 1611 HIS A HD2  1 
ATOM   2410 H  HE1  . HIS A 1 152 ? -9.30404  -15.08547 -10.79651 1.000 11.31578 ? 1611 HIS A HE1  1 
ATOM   2411 H  HE2  . HIS A 1 152 ? -11.39475 -15.65380 -9.79389  1.000 11.26206 ? 1611 HIS A HE2  1 
ATOM   2412 N  N    . ILE A 1 153 ? -10.62902 -11.45392 -7.11469  1.000 8.27968  ? 1612 ILE A N    1 
ATOM   2413 C  CA   . ILE A 1 153 ? -11.95530 -10.87171 -7.19565  1.000 8.31389  ? 1612 ILE A CA   1 
ATOM   2414 C  C    . ILE A 1 153 ? -12.83681 -11.72617 -8.12082  1.000 6.45061  ? 1612 ILE A C    1 
ATOM   2415 O  O    . ILE A 1 153 ? -12.56880 -11.88472 -9.29511  1.000 8.03224  ? 1612 ILE A O    1 
ATOM   2416 C  CB   . ILE A 1 153 ? -11.89976 -9.41972  -7.70088  1.000 8.85084  ? 1612 ILE A CB   1 
ATOM   2417 C  CG1  . ILE A 1 153 ? -10.87002 -8.60122  -6.89058  1.000 10.15094 ? 1612 ILE A CG1  1 
ATOM   2418 C  CG2  . ILE A 1 153 ? -13.30440 -8.80668  -7.64780  1.000 9.32192  ? 1612 ILE A CG2  1 
ATOM   2419 C  CD1  . ILE A 1 153 ? -11.14400 -8.48507  -5.43127  1.000 11.12211 ? 1612 ILE A CD1  1 
ATOM   2420 H  H    . ILE A 1 153 ? -10.11058 -11.23009 -7.76332  1.000 9.93562  ? 1612 ILE A H    1 
ATOM   2421 H  HA   . ILE A 1 153 ? -12.34759 -10.88968 -6.30869  1.000 9.97667  ? 1612 ILE A HA   1 
ATOM   2422 H  HB   . ILE A 1 153 ? -11.60151 -9.40773  -8.62381  1.000 10.62101 ? 1612 ILE A HB   1 
ATOM   2423 H  HG12 . ILE A 1 153 ? -10.00165 -9.02237  -6.98795  1.000 12.18113 ? 1612 ILE A HG12 1 
ATOM   2424 H  HG13 . ILE A 1 153 ? -10.84455 -7.70117  -7.25136  1.000 12.18113 ? 1612 ILE A HG13 1 
ATOM   2425 H  HG21 . ILE A 1 153 ? -13.24062 -7.85520  -7.82532  1.000 11.18631 ? 1612 ILE A HG21 1 
ATOM   2426 H  HG22 . ILE A 1 153 ? -13.86017 -9.23197  -8.31948  1.000 11.18631 ? 1612 ILE A HG22 1 
ATOM   2427 H  HG23 . ILE A 1 153 ? -13.68020 -8.95415  -6.76579  1.000 11.18631 ? 1612 ILE A HG23 1 
ATOM   2428 H  HD11 . ILE A 1 153 ? -10.48567 -7.89485  -5.03234  1.000 13.34654 ? 1612 ILE A HD11 1 
ATOM   2429 H  HD12 . ILE A 1 153 ? -12.03420 -8.12105  -5.30507  1.000 13.34654 ? 1612 ILE A HD12 1 
ATOM   2430 H  HD13 . ILE A 1 153 ? -11.08642 -9.36543  -5.02809  1.000 13.34654 ? 1612 ILE A HD13 1 
ATOM   2431 N  N    . CYS A 1 154 ? -13.95698 -12.20266 -7.54372  1.000 7.85071  ? 1613 CYS A N    1 
ATOM   2432 C  CA   . CYS A 1 154 ? -14.90955 -13.00081 -8.31005  1.000 7.80603  ? 1613 CYS A CA   1 
ATOM   2433 C  C    . CYS A 1 154 ? -15.72228 -12.10943 -9.26784  1.000 8.04020  ? 1613 CYS A C    1 
ATOM   2434 O  O    . CYS A 1 154 ? -15.86586 -10.89913 -9.05841  1.000 8.69025  ? 1613 CYS A O    1 
ATOM   2435 C  CB   . CYS A 1 154 ? -15.88559 -13.68784 -7.37546  1.000 9.36925  ? 1613 CYS A CB   1 
ATOM   2436 S  SG   . CYS A 1 154 ? -15.09240 -14.92846 -6.28321  1.000 10.10331 ? 1613 CYS A SG   1 
ATOM   2437 H  H    . CYS A 1 154 ? -14.17765 -12.07532 -6.72232  1.000 9.42085  ? 1613 CYS A H    1 
ATOM   2438 H  HA   . CYS A 1 154 ? -14.42034 -13.66355 -8.82225  1.000 9.36724  ? 1613 CYS A HA   1 
ATOM   2439 H  HB2  . CYS A 1 154 ? -16.30400 -13.01842 -6.81180  1.000 11.24310 ? 1613 CYS A HB2  1 
ATOM   2440 H  HB3  . CYS A 1 154 ? -16.55865 -14.14353 -7.90483  1.000 11.24310 ? 1613 CYS A HB3  1 
ATOM   2441 N  N    . HIS A 1 155 ? -16.26133 -12.72919 -10.29977 1.000 8.34545  ? 1614 HIS A N    1 
ATOM   2442 C  CA   . HIS A 1 155 ? -17.19761 -12.17020 -11.26332 1.000 8.17705  ? 1614 HIS A CA   1 
ATOM   2443 C  C    . HIS A 1 155 ? -17.14323 -10.63447 -11.34468 1.000 8.91137  ? 1614 HIS A C    1 
ATOM   2444 O  O    . HIS A 1 155 ? -18.05072 -9.93821  -10.86957 1.000 9.87724  ? 1614 HIS A O    1 
ATOM   2445 C  CB   . HIS A 1 155 ? -18.64092 -12.68784 -11.03326 1.000 8.12968  ? 1614 HIS A CB   1 
ATOM   2446 C  CG   . HIS A 1 155 ? -19.08077 -12.65919 -9.62039  1.000 8.74031  ? 1614 HIS A CG   1 
ATOM   2447 N  ND1  . HIS A 1 155 ? -18.84742 -11.62263 -8.76140  1.000 8.16390  ? 1614 HIS A ND1  1 
ATOM   2448 C  CD2  . HIS A 1 155 ? -19.76419 -13.58886 -8.89815  1.000 9.56668  ? 1614 HIS A CD2  1 
ATOM   2449 C  CE1  . HIS A 1 155 ? -19.33766 -11.88900 -7.56917  1.000 9.87723  ? 1614 HIS A CE1  1 
ATOM   2450 N  NE2  . HIS A 1 155 ? -19.92812 -13.08809 -7.63160  1.000 10.21671 ? 1614 HIS A NE2  1 
ATOM   2451 H  H    . HIS A 1 155 ? -16.08743 -13.55089 -10.48463 1.000 10.01455 ? 1614 HIS A H    1 
ATOM   2452 H  HA   . HIS A 1 155 ? -16.92205 -12.48660 -12.13788 1.000 9.81246  ? 1614 HIS A HA   1 
ATOM   2453 H  HB2  . HIS A 1 155 ? -19.25331 -12.13439 -11.54274 1.000 9.75562  ? 1614 HIS A HB2  1 
ATOM   2454 H  HB3  . HIS A 1 155 ? -18.69252 -13.60718 -11.33829 1.000 9.75562  ? 1614 HIS A HB3  1 
ATOM   2455 H  HD1  . HIS A 1 155 ? -18.43695 -10.89647 -8.97073  1.000 9.79668  ? 1614 HIS A HD1  1 
ATOM   2456 H  HD2  . HIS A 1 155 ? -20.06499 -14.41291 -9.20694  1.000 11.48001 ? 1614 HIS A HD2  1 
ATOM   2457 H  HE1  . HIS A 1 155 ? -19.28341 -11.34234 -6.81875  1.000 11.85267 ? 1614 HIS A HE1  1 
ATOM   2458 N  N    . VAL A 1 156 ? -16.12080 -10.12691 -12.00339 1.000 9.06132  ? 1615 VAL A N    1 
ATOM   2459 C  CA   . VAL A 1 156 ? -15.99724 -8.70288  -12.26048 1.000 8.59819  ? 1615 VAL A CA   1 
ATOM   2460 C  C    . VAL A 1 156 ? -16.95713 -8.36263  -13.39564 1.000 8.38771  ? 1615 VAL A C    1 
ATOM   2461 O  O    . VAL A 1 156 ? -17.00284 -9.03701  -14.44002 1.000 9.85611  ? 1615 VAL A O    1 
ATOM   2462 C  CB   . VAL A 1 156 ? -14.54153 -8.34504  -12.59583 1.000 9.30357  ? 1615 VAL A CB   1 
ATOM   2463 C  CG1  . VAL A 1 156 ? -14.46974 -6.91709  -13.10872 1.000 10.76150 ? 1615 VAL A CG1  1 
ATOM   2464 C  CG2  . VAL A 1 156 ? -13.69079 -8.49510  -11.39963 1.000 10.41937 ? 1615 VAL A CG2  1 
ATOM   2465 H  H    . VAL A 1 156 ? -15.47093 -10.59322 -12.31934 1.000 10.87359 ? 1615 VAL A H    1 
ATOM   2466 H  HA   . VAL A 1 156 ? -16.24631 -8.18458  -11.47930 1.000 10.31783 ? 1615 VAL A HA   1 
ATOM   2467 H  HB   . VAL A 1 156 ? -14.21347 -8.94479  -13.28399 1.000 11.16429 ? 1615 VAL A HB   1 
ATOM   2468 H  HG11 . VAL A 1 156 ? -13.54776 -6.61709  -13.07966 1.000 12.91381 ? 1615 VAL A HG11 1 
ATOM   2469 H  HG12 . VAL A 1 156 ? -14.79696 -6.89257  -14.02153 1.000 12.91381 ? 1615 VAL A HG12 1 
ATOM   2470 H  HG13 . VAL A 1 156 ? -15.01972 -6.35098  -12.54485 1.000 12.91381 ? 1615 VAL A HG13 1 
ATOM   2471 H  HG21 . VAL A 1 156 ? -12.77609 -8.27158  -11.63258 1.000 12.50325 ? 1615 VAL A HG21 1 
ATOM   2472 H  HG22 . VAL A 1 156 ? -14.01143 -7.89653  -10.70695 1.000 12.50325 ? 1615 VAL A HG22 1 
ATOM   2473 H  HG23 . VAL A 1 156 ? -13.73860 -9.41355  -11.09130 1.000 12.50325 ? 1615 VAL A HG23 1 
ATOM   2474 N  N    . ALA A 1 157 ? -17.79074 -7.31833  -13.18457 1.000 8.93245  ? 1616 ALA A N    1 
ATOM   2475 C  CA   . ALA A 1 157 ? -18.94293 -7.06484  -14.04996 1.000 9.94574  ? 1616 ALA A CA   1 
ATOM   2476 C  C    . ALA A 1 157 ? -19.04894 -5.66174  -14.59313 1.000 10.21939 ? 1616 ALA A C    1 
ATOM   2477 O  O    . ALA A 1 157 ? -19.94727 -5.40914  -15.39941 1.000 11.35898 ? 1616 ALA A O    1 
ATOM   2478 C  CB   . ALA A 1 157 ? -20.22950 -7.35025  -13.27962 1.000 12.32744 ? 1616 ALA A CB   1 
ATOM   2479 H  H    . ALA A 1 157 ? -17.70171 -6.74963  -12.54562 1.000 10.71895 ? 1616 ALA A H    1 
ATOM   2480 H  HA   . ALA A 1 157 ? -18.87255 -7.66157  -14.81145 1.000 11.93489 ? 1616 ALA A HA   1 
ATOM   2481 H  HB1  . ALA A 1 157 ? -20.98885 -7.17586  -13.85744 1.000 14.79293 ? 1616 ALA A HB1  1 
ATOM   2482 H  HB2  . ALA A 1 157 ? -20.23173 -8.27964  -13.00190 1.000 14.79293 ? 1616 ALA A HB2  1 
ATOM   2483 H  HB3  . ALA A 1 157 ? -20.26642 -6.77239  -12.50141 1.000 14.79293 ? 1616 ALA A HB3  1 
ATOM   2484 N  N    . ARG A 1 158 ? -18.20579 -4.74392  -14.15507 1.000 10.10362 ? 1617 ARG A N    1 
ATOM   2485 C  CA   . ARG A 1 158 ? -18.39289 -3.33636  -14.43179 1.000 10.29046 ? 1617 ARG A CA   1 
ATOM   2486 C  C    . ARG A 1 158 ? -17.09673 -2.70588  -14.90738 1.000 9.58518  ? 1617 ARG A C    1 
ATOM   2487 O  O    . ARG A 1 158 ? -15.98943 -3.04570  -14.43362 1.000 10.39309 ? 1617 ARG A O    1 
ATOM   2488 C  CB   . ARG A 1 158 ? -18.80968 -2.62400  -13.14242 1.000 10.75116 ? 1617 ARG A CB   1 
ATOM   2489 C  CG   . ARG A 1 158 ? -20.14116 -3.02757  -12.60018 1.000 13.27498 ? 1617 ARG A CG   1 
ATOM   2490 C  CD   . ARG A 1 158 ? -20.39371 -2.39991  -11.22279 1.000 13.97245 ? 1617 ARG A CD   1 
ATOM   2491 N  NE   . ARG A 1 158 ? -21.75196 -2.54003  -10.70468 1.000 15.28841 ? 1617 ARG A NE   1 
ATOM   2492 C  CZ   . ARG A 1 158 ? -22.19303 -3.58611  -10.01893 1.000 15.06472 ? 1617 ARG A CZ   1 
ATOM   2493 N  NH1  . ARG A 1 158 ? -21.35169 -4.57016  -9.60671  1.000 13.73827 ? 1617 ARG A NH1  1 
ATOM   2494 N  NH2  . ARG A 1 158 ? -23.49328 -3.65358  -9.74467  1.000 15.96214 ? 1617 ARG A NH2  1 
ATOM   2495 H  H    . ARG A 1 158 ? -17.50543 -4.91705  -13.68696 1.000 12.12434 ? 1617 ARG A H    1 
ATOM   2496 H  HA   . ARG A 1 158 ? -19.05642 -3.22685  -15.13081 1.000 12.34855 ? 1617 ARG A HA   1 
ATOM   2497 H  HB2  . ARG A 1 158 ? -18.14782 -2.81384  -12.45919 1.000 12.90139 ? 1617 ARG A HB2  1 
ATOM   2498 H  HB3  . ARG A 1 158 ? -18.84331 -1.67022  -13.31584 1.000 12.90139 ? 1617 ARG A HB3  1 
ATOM   2499 H  HG2  . ARG A 1 158 ? -20.83900 -2.73000  -13.20464 1.000 15.92998 ? 1617 ARG A HG2  1 
ATOM   2500 H  HG3  . ARG A 1 158 ? -20.17221 -3.99259  -12.50703 1.000 15.92998 ? 1617 ARG A HG3  1 
ATOM   2501 H  HD2  . ARG A 1 158 ? -19.79718 -2.81846  -10.58258 1.000 16.76693 ? 1617 ARG A HD2  1 
ATOM   2502 H  HD3  . ARG A 1 158 ? -20.20465 -1.45028  -11.28076 1.000 16.76693 ? 1617 ARG A HD3  1 
ATOM   2503 H  HE   . ARG A 1 158 ? -22.30499 -1.89878  -10.85488 1.000 18.34609 ? 1617 ARG A HE   1 
ATOM   2504 H  HH11 . ARG A 1 158 ? -20.51265 -4.52306  -9.78942  1.000 16.48592 ? 1617 ARG A HH11 1 
ATOM   2505 H  HH12 . ARG A 1 158 ? -21.65821 -5.24011  -9.16307  1.000 16.48592 ? 1617 ARG A HH12 1 
ATOM   2506 H  HH21 . ARG A 1 158 ? -24.02179 -3.02945  -10.01062 1.000 19.15457 ? 1617 ARG A HH21 1 
ATOM   2507 H  HH22 . ARG A 1 158 ? -23.80516 -4.32133  -9.30145  1.000 19.15457 ? 1617 ARG A HH22 1 
ATOM   2508 N  N    . LYS A 1 159 ? -17.25600 -1.65298  -15.73370 1.000 10.16676 ? 1618 LYS A N    1 
ATOM   2509 C  CA   . LYS A 1 159 ? -16.13349 -0.82561  -16.10282 1.000 10.94317 ? 1618 LYS A CA   1 
ATOM   2510 C  C    . LYS A 1 159 ? -15.40216 -0.29802  -14.87560 1.000 10.84581 ? 1618 LYS A C    1 
ATOM   2511 O  O    . LYS A 1 159 ? -14.16359 -0.32740  -14.79017 1.000 11.37478 ? 1618 LYS A O    1 
ATOM   2512 C  CB   . LYS A 1 159 ? -16.65897 0.35221   -16.97748 1.000 11.80643 ? 1618 LYS A CB   1 
ATOM   2513 C  CG   . LYS A 1 159 ? -15.60007 1.37010   -17.32934 1.000 13.04622 ? 1618 LYS A CG   1 
ATOM   2514 C  CD   . LYS A 1 159 ? -16.21168 2.47091   -18.18621 1.000 17.09923 ? 1618 LYS A CD   1 
ATOM   2515 C  CE   . LYS A 1 159 ? -15.15637 3.31455   -18.89485 1.000 22.51815 ? 1618 LYS A CE   1 
ATOM   2516 N  NZ   . LYS A 1 159 ? -15.78613 4.49533   -19.54956 1.000 26.30800 ? 1618 LYS A NZ   1 
ATOM   2517 H  H    . LYS A 1 159 ? -18.00425 -1.41213  -16.08258 1.000 12.20011 ? 1618 LYS A H    1 
ATOM   2518 H  HA   . LYS A 1 159 ? -15.49570 -1.34502  -16.61695 1.000 13.13180 ? 1618 LYS A HA   1 
ATOM   2519 H  HB2  . LYS A 1 159 ? -17.01025 -0.00810  -17.80675 1.000 14.16772 ? 1618 LYS A HB2  1 
ATOM   2520 H  HB3  . LYS A 1 159 ? -17.36146 0.81188   -16.49157 1.000 14.16772 ? 1618 LYS A HB3  1 
ATOM   2521 H  HG2  . LYS A 1 159 ? -15.24365 1.76650   -16.51895 1.000 15.65546 ? 1618 LYS A HG2  1 
ATOM   2522 H  HG3  . LYS A 1 159 ? -14.88796 0.94303   -17.83074 1.000 15.65546 ? 1618 LYS A HG3  1 
ATOM   2523 H  HD2  . LYS A 1 159 ? -16.77862 2.06851   -18.86264 1.000 20.51908 ? 1618 LYS A HD2  1 
ATOM   2524 H  HD3  . LYS A 1 159 ? -16.73628 3.05888   -17.62055 1.000 20.51908 ? 1618 LYS A HD3  1 
ATOM   2525 H  HE2  . LYS A 1 159 ? -14.50494 3.62986   -18.24901 1.000 27.02179 ? 1618 LYS A HE2  1 
ATOM   2526 H  HE3  . LYS A 1 159 ? -14.71722 2.78107   -19.57563 1.000 27.02179 ? 1618 LYS A HE3  1 
ATOM   2527 H  HZ1  . LYS A 1 159 ? -16.40160 4.22717   -20.13385 1.000 31.56960 ? 1618 LYS A HZ1  1 
ATOM   2528 H  HZ2  . LYS A 1 159 ? -16.17452 5.01165   -18.93745 1.000 31.56960 ? 1618 LYS A HZ2  1 
ATOM   2529 H  HZ3  . LYS A 1 159 ? -15.16830 4.97096   -19.97870 1.000 31.56960 ? 1618 LYS A HZ3  1 
ATOM   2530 N  N    . GLU A 1 160 ? -16.16034 0.15658   -13.88952 1.000 10.04050 ? 1619 GLU A N    1 
ATOM   2531 C  CA   . GLU A 1 160 ? -15.59643 0.69765   -12.66400 1.000 11.21958 ? 1619 GLU A CA   1 
ATOM   2532 C  C    . GLU A 1 160 ? -14.64070 -0.28867  -12.00533 1.000 11.46161 ? 1619 GLU A C    1 
ATOM   2533 O  O    . GLU A 1 160 ? -13.54527 0.06839   -11.54650 1.000 11.46693 ? 1619 GLU A O    1 
ATOM   2534 C  CB   . GLU A 1 160 ? -16.75334 1.02505   -11.69394 1.000 13.32497 ? 1619 GLU A CB   1 
ATOM   2535 C  CG   . GLU A 1 160 ? -16.36604 1.30326   -10.30396 1.000 14.50935 ? 1619 GLU A CG   1 
ATOM   2536 C  CD   . GLU A 1 160 ? -17.54059 1.53199   -9.35612  1.000 14.31734 ? 1619 GLU A CD   1 
ATOM   2537 O  OE1  . GLU A 1 160 ? -18.70656 1.17215   -9.70662  1.000 15.60157 ? 1619 GLU A OE1  1 
ATOM   2538 O  OE2  . GLU A 1 160 ? -17.30577 2.08188   -8.26173  1.000 15.55157 ? 1619 GLU A OE2  1 
ATOM   2539 H  H    . GLU A 1 160 ? -17.02019 0.16363   -13.90422 1.000 12.04860 ? 1619 GLU A H    1 
ATOM   2540 H  HA   . GLU A 1 160 ? -15.09993 1.50569   -12.86765 1.000 13.46350 ? 1619 GLU A HA   1 
ATOM   2541 H  HB2  . GLU A 1 160 ? -17.21468 1.81101   -12.02610 1.000 15.98996 ? 1619 GLU A HB2  1 
ATOM   2542 H  HB3  . GLU A 1 160 ? -17.35879 0.26739   -11.67699 1.000 15.98996 ? 1619 GLU A HB3  1 
ATOM   2543 H  HG2  . GLU A 1 160 ? -15.85986 0.54784   -9.96627  1.000 17.41122 ? 1619 GLU A HG2  1 
ATOM   2544 H  HG3  . GLU A 1 160 ? -15.81767 2.10324   -10.28934 1.000 17.41122 ? 1619 GLU A HG3  1 
ATOM   2545 N  N    . GLU A 1 161 ? -15.06547 -1.54660  -11.94404 1.000 10.26418 ? 1620 GLU A N    1 
ATOM   2546 C  CA   . GLU A 1 161 ? -14.30459 -2.56805  -11.24900 1.000 9.96146  ? 1620 GLU A CA   1 
ATOM   2547 C  C    . GLU A 1 161 ? -13.04898 -2.96334  -12.01960 1.000 8.51138  ? 1620 GLU A C    1 
ATOM   2548 O  O    . GLU A 1 161 ? -11.97003 -3.11340  -11.42324 1.000 9.99039  ? 1620 GLU A O    1 
ATOM   2549 C  CB   . GLU A 1 161 ? -15.20419 -3.78373  -11.02330 1.000 10.63259 ? 1620 GLU A CB   1 
ATOM   2550 C  CG   . GLU A 1 161 ? -16.39752 -3.56172  -10.09989 1.000 11.15637 ? 1620 GLU A CG   1 
ATOM   2551 C  CD   . GLU A 1 161 ? -17.52197 -4.57366  -10.22063 1.000 10.73537 ? 1620 GLU A CD   1 
ATOM   2552 O  OE1  . GLU A 1 161 ? -17.53240 -5.36945  -11.16974 1.000 11.88273 ? 1620 GLU A OE1  1 
ATOM   2553 O  OE2  . GLU A 1 161 ? -18.41450 -4.49243  -9.33905  1.000 12.12742 ? 1620 GLU A OE2  1 
ATOM   2554 H  H    . GLU A 1 161 ? -15.79449 -1.83315  -12.29902 1.000 12.31701 ? 1620 GLU A H    1 
ATOM   2555 H  HA   . GLU A 1 161 ? -14.01566 -2.22077  -10.39062 1.000 11.95375 ? 1620 GLU A HA   1 
ATOM   2556 H  HB2  . GLU A 1 161 ? -15.55404 -4.06693  -11.88254 1.000 12.75911 ? 1620 GLU A HB2  1 
ATOM   2557 H  HB3  . GLU A 1 161 ? -14.66705 -4.49153  -10.63419 1.000 12.75911 ? 1620 GLU A HB3  1 
ATOM   2558 H  HG2  . GLU A 1 161 ? -16.08250 -3.59065  -9.18292  1.000 13.38764 ? 1620 GLU A HG2  1 
ATOM   2559 H  HG3  . GLU A 1 161 ? -16.77443 -2.68924  -10.29383 1.000 13.38764 ? 1620 GLU A HG3  1 
ATOM   2560 N  N    . ILE A 1 162 ? -13.17716 -3.17264  -13.31747 1.000 8.99291  ? 1621 ILE A N    1 
ATOM   2561 C  CA   . ILE A 1 162 ? -12.03068 -3.61490  -14.09815 1.000 9.11405  ? 1621 ILE A CA   1 
ATOM   2562 C  C    . ILE A 1 162 ? -10.97071 -2.51878  -14.14192 1.000 9.99568  ? 1621 ILE A C    1 
ATOM   2563 O  O    . ILE A 1 162 ? -9.78276  -2.81237  -14.12476 1.000 10.55627 ? 1621 ILE A O    1 
ATOM   2564 C  CB   . ILE A 1 162 ? -12.41471 -4.15525  -15.48835 1.000 9.84833  ? 1621 ILE A CB   1 
ATOM   2565 C  CG1  . ILE A 1 162 ? -11.32525 -5.08450  -16.06718 1.000 10.44047 ? 1621 ILE A CG1  1 
ATOM   2566 C  CG2  . ILE A 1 162 ? -12.72242 -3.04005  -16.46611 1.000 11.20630 ? 1621 ILE A CG2  1 
ATOM   2567 C  CD1  . ILE A 1 162 ? -11.16393 -6.38080  -15.30169 1.000 11.38533 ? 1621 ILE A CD1  1 
ATOM   2568 H  H    . ILE A 1 162 ? -13.90325 -3.06878  -13.76647 1.000 10.79150 ? 1621 ILE A H    1 
ATOM   2569 H  HA   . ILE A 1 162 ? -11.64743 -4.38218  -13.64506 1.000 10.93686 ? 1621 ILE A HA   1 
ATOM   2570 H  HB   . ILE A 1 162 ? -13.22193 -4.67724  -15.35865 1.000 11.81800 ? 1621 ILE A HB   1 
ATOM   2571 H  HG12 . ILE A 1 162 ? -11.55847 -5.30731  -16.98198 1.000 12.52857 ? 1621 ILE A HG12 1 
ATOM   2572 H  HG13 . ILE A 1 162 ? -10.47427 -4.61945  -16.04562 1.000 12.52857 ? 1621 ILE A HG13 1 
ATOM   2573 H  HG21 . ILE A 1 162 ? -13.11745 -3.42126  -17.26582 1.000 13.44756 ? 1621 ILE A HG21 1 
ATOM   2574 H  HG22 . ILE A 1 162 ? -13.34415 -2.42055  -16.05310 1.000 13.44756 ? 1621 ILE A HG22 1 
ATOM   2575 H  HG23 . ILE A 1 162 ? -11.89814 -2.58082  -16.69097 1.000 13.44756 ? 1621 ILE A HG23 1 
ATOM   2576 H  HD11 . ILE A 1 162 ? -10.62629 -6.99334  -15.82766 1.000 13.66239 ? 1621 ILE A HD11 1 
ATOM   2577 H  HD12 . ILE A 1 162 ? -10.72410 -6.19617  -14.45709 1.000 13.66239 ? 1621 ILE A HD12 1 
ATOM   2578 H  HD13 . ILE A 1 162 ? -12.04047 -6.76404  -15.14134 1.000 13.66239 ? 1621 ILE A HD13 1 
ATOM   2579 N  N    . LEU A 1 163 ? -11.39369 -1.26009  -14.17110 1.000 10.12206 ? 1622 LEU A N    1 
ATOM   2580 C  CA   . LEU A 1 163 ? -10.41511 -0.15759  -14.19086 1.000 10.54047 ? 1622 LEU A CA   1 
ATOM   2581 C  C    . LEU A 1 163 ? -9.72988  0.00051   -12.85034 1.000 10.20365 ? 1622 LEU A C    1 
ATOM   2582 O  O    . LEU A 1 163 ? -8.53964  0.33633   -12.79176 1.000 11.49849 ? 1622 LEU A O    1 
ATOM   2583 C  CB   . LEU A 1 163 ? -11.06108 1.14967   -14.64528 1.000 10.31943 ? 1622 LEU A CB   1 
ATOM   2584 C  CG   . LEU A 1 163 ? -11.47026 1.19266   -16.08049 1.000 11.57491 ? 1622 LEU A CG   1 
ATOM   2585 C  CD1  . LEU A 1 163 ? -12.08842 2.55313   -16.41437 1.000 13.63028 ? 1622 LEU A CD1  1 
ATOM   2586 C  CD2  . LEU A 1 163 ? -10.31285 0.86812   -17.04428 1.000 13.22496 ? 1622 LEU A CD2  1 
ATOM   2587 H  H    . LEU A 1 163 ? -12.21778 -1.01435  -14.18000 1.000 12.14647 ? 1622 LEU A H    1 
ATOM   2588 H  HA   . LEU A 1 163 ? -9.73351  -0.37238  -14.84674 1.000 12.64857 ? 1622 LEU A HA   1 
ATOM   2589 H  HB2  . LEU A 1 163 ? -11.85736 1.29840   -14.11169 1.000 12.38332 ? 1622 LEU A HB2  1 
ATOM   2590 H  HB3  . LEU A 1 163 ? -10.42677 1.86949   -14.50244 1.000 12.38332 ? 1622 LEU A HB3  1 
ATOM   2591 H  HG   . LEU A 1 163 ? -12.13623 0.50063   -16.21645 1.000 13.88989 ? 1622 LEU A HG   1 
ATOM   2592 H  HD11 . LEU A 1 163 ? -12.34222 2.56348   -17.35052 1.000 16.35633 ? 1622 LEU A HD11 1 
ATOM   2593 H  HD12 . LEU A 1 163 ? -12.87114 2.68947   -15.85791 1.000 16.35633 ? 1622 LEU A HD12 1 
ATOM   2594 H  HD13 . LEU A 1 163 ? -11.43436 3.24822   -16.24127 1.000 16.35633 ? 1622 LEU A HD13 1 
ATOM   2595 H  HD21 . LEU A 1 163 ? -10.56754 1.12951   -17.94301 1.000 15.86995 ? 1622 LEU A HD21 1 
ATOM   2596 H  HD22 . LEU A 1 163 ? -9.52409  1.36030   -16.76765 1.000 15.86995 ? 1622 LEU A HD22 1 
ATOM   2597 H  HD23 . LEU A 1 163 ? -10.13520 -0.08502  -17.01484 1.000 15.86995 ? 1622 LEU A HD23 1 
ATOM   2598 N  N    A LEU A 1 164 ? -10.44416 -0.20892  -11.75060 0.461 10.10098 ? 1623 LEU A N    1 
ATOM   2599 N  N    B LEU A 1 164 ? -10.44498 -0.20634  -11.75547 0.539 10.12730 ? 1623 LEU A N    1 
ATOM   2600 C  CA   A LEU A 1 164 ? -9.81789  -0.21824  -10.44345 0.461 10.39574 ? 1623 LEU A CA   1 
ATOM   2601 C  CA   B LEU A 1 164 ? -9.82863  -0.22046  -10.44892 0.539 10.54314 ? 1623 LEU A CA   1 
ATOM   2602 C  C    A LEU A 1 164 ? -8.76904  -1.32111  -10.34262 0.461 10.45103 ? 1623 LEU A C    1 
ATOM   2603 C  C    B LEU A 1 164 ? -8.77404  -1.31885  -10.34279 0.539 10.59579 ? 1623 LEU A C    1 
ATOM   2604 O  O    A LEU A 1 164 ? -7.64222  -1.09462  -9.89554  0.461 10.61153 ? 1623 LEU A O    1 
ATOM   2605 O  O    B LEU A 1 164 ? -7.64917  -1.08675  -9.89479  0.539 10.68259 ? 1623 LEU A O    1 
ATOM   2606 C  CB   A LEU A 1 164 ? -10.87143 -0.33481  -9.35397  0.461 11.45647 ? 1623 LEU A CB   1 
ATOM   2607 C  CB   B LEU A 1 164 ? -10.89578 -0.34731  -9.38085  0.539 11.97758 ? 1623 LEU A CB   1 
ATOM   2608 C  CG   A LEU A 1 164 ? -10.48653 -0.06956  -7.90091  0.461 13.76191 ? 1623 LEU A CG   1 
ATOM   2609 C  CG   B LEU A 1 164 ? -10.43269 -0.51377  -7.95157  0.539 14.85941 ? 1623 LEU A CG   1 
ATOM   2610 C  CD1  A LEU A 1 164 ? -9.61536  -1.20699  -7.32269  0.461 15.44889 ? 1623 LEU A CD1  1 
ATOM   2611 C  CD1  B LEU A 1 164 ? -9.64880  0.70589   -7.48882  0.539 15.73055 ? 1623 LEU A CD1  1 
ATOM   2612 C  CD2  A LEU A 1 164 ? -9.81289  1.29494   -7.74167  0.461 13.70930 ? 1623 LEU A CD2  1 
ATOM   2613 C  CD2  B LEU A 1 164 ? -11.64303 -0.73984  -7.04980  0.539 16.58851 ? 1623 LEU A CD2  1 
ATOM   2614 H  H    A LEU A 1 164 ? -11.29275 -0.34789  -11.73708 0.461 12.12117 ? 1623 LEU A H    1 
ATOM   2615 H  H    B LEU A 1 164 ? -11.29420 -0.34171  -11.74510 0.539 12.15277 ? 1623 LEU A H    1 
ATOM   2616 H  HA   A LEU A 1 164 ? -9.36079  0.62627   -10.30652 0.461 12.47489 ? 1623 LEU A HA   1 
ATOM   2617 H  HA   B LEU A 1 164 ? -9.37044  0.62160   -10.30092 0.539 12.65177 ? 1623 LEU A HA   1 
ATOM   2618 H  HB2  A LEU A 1 164 ? -11.57727 0.29545   -9.56718  0.461 13.74776 ? 1623 LEU A HB2  1 
ATOM   2619 H  HB2  B LEU A 1 164 ? -11.44029 0.45497   -9.40839  0.539 14.37309 ? 1623 LEU A HB2  1 
ATOM   2620 H  HB3  A LEU A 1 164 ? -11.21614 -1.24105  -9.38236  0.461 13.74776 ? 1623 LEU A HB3  1 
ATOM   2621 H  HB3  B LEU A 1 164 ? -11.43754 -1.12342  -9.59310  0.539 14.37309 ? 1623 LEU A HB3  1 
ATOM   2622 H  HG   A LEU A 1 164 ? -11.30150 -0.04788  -7.37531  0.461 16.51430 ? 1623 LEU A HG   1 
ATOM   2623 H  HG   B LEU A 1 164 ? -9.84282  -1.28142  -7.89110  0.539 17.83129 ? 1623 LEU A HG   1 
ATOM   2624 H  HD11 A LEU A 1 164 ? -9.63659  -1.15981  -6.35407  0.461 18.53866 ? 1623 LEU A HD11 1 
ATOM   2625 H  HD11 B LEU A 1 164 ? -9.25246  0.51704   -6.62386  0.539 18.87666 ? 1623 LEU A HD11 1 
ATOM   2626 H  HD12 A LEU A 1 164 ? -9.97049  -2.05920  -7.62021  0.461 18.53866 ? 1623 LEU A HD12 1 
ATOM   2627 H  HD12 B LEU A 1 164 ? -8.95294  0.89848   -8.13657  0.539 18.87666 ? 1623 LEU A HD12 1 
ATOM   2628 H  HD13 A LEU A 1 164 ? -8.70479  -1.09945  -7.63922  0.461 18.53866 ? 1623 LEU A HD13 1 
ATOM   2629 H  HD13 B LEU A 1 164 ? -10.25301 1.46140   -7.41795  0.539 18.87666 ? 1623 LEU A HD13 1 
ATOM   2630 H  HD21 A LEU A 1 164 ? -9.67759  1.47208   -6.79763  0.461 16.45116 ? 1623 LEU A HD21 1 
ATOM   2631 H  HD21 B LEU A 1 164 ? -11.34100 -1.09373  -6.19866  0.539 19.90622 ? 1623 LEU A HD21 1 
ATOM   2632 H  HD22 A LEU A 1 164 ? -8.95883  1.28105   -8.20134  0.461 16.45116 ? 1623 LEU A HD22 1 
ATOM   2633 H  HD22 B LEU A 1 164 ? -12.09782 0.10606   -6.91367  0.539 19.90622 ? 1623 LEU A HD22 1 
ATOM   2634 H  HD23 A LEU A 1 164 ? -10.38512 1.97658   -8.12744  0.461 16.45116 ? 1623 LEU A HD23 1 
ATOM   2635 H  HD23 B LEU A 1 164 ? -12.24162 -1.37218  -7.47727  0.539 19.90622 ? 1623 LEU A HD23 1 
ATOM   2636 N  N    . ILE A 1 165 ? -9.13241  -2.53992  -10.76913 1.000 10.72212 ? 1624 ILE A N    1 
ATOM   2637 C  CA   . ILE A 1 165 ? -8.18321  -3.64553  -10.74013 1.000 9.96671  ? 1624 ILE A CA   1 
ATOM   2638 C  C    . ILE A 1 165 ? -6.98945  -3.34333  -11.63023 1.000 10.36151 ? 1624 ILE A C    1 
ATOM   2639 O  O    . ILE A 1 165 ? -5.84748  -3.63414  -11.26185 1.000 10.68787 ? 1624 ILE A O    1 
ATOM   2640 C  CB   . ILE A 1 165 ? -8.89803  -4.94458  -11.11208 1.000 9.11410  ? 1624 ILE A CB   1 
ATOM   2641 C  CG1  . ILE A 1 165 ? -9.88335  -5.32162  -9.99583  1.000 9.80616  ? 1624 ILE A CG1  1 
ATOM   2642 C  CG2  . ILE A 1 165 ? -7.88062  -6.08769  -11.32774 1.000 10.47729 ? 1624 ILE A CG2  1 
ATOM   2643 C  CD1  . ILE A 1 165 ? -10.95153 -6.30175  -10.41316 1.000 10.78788 ? 1624 ILE A CD1  1 
ATOM   2644 H  H    . ILE A 1 165 ? -9.91071  -2.74215  -11.07401 1.000 12.86654 ? 1624 ILE A H    1 
ATOM   2645 H  HA   . ILE A 1 165 ? -7.83665  -3.75332  -9.84059  1.000 11.96006 ? 1624 ILE A HA   1 
ATOM   2646 H  HB   . ILE A 1 165 ? -9.38183  -4.80634  -11.94137 1.000 10.93692 ? 1624 ILE A HB   1 
ATOM   2647 H  HG12 . ILE A 1 165 ? -9.38573  -5.72295  -9.26630  1.000 11.76739 ? 1624 ILE A HG12 1 
ATOM   2648 H  HG13 . ILE A 1 165 ? -10.32800 -4.51553  -9.69021  1.000 11.76739 ? 1624 ILE A HG13 1 
ATOM   2649 H  HG21 . ILE A 1 165 ? -8.35472  -6.93380  -11.34257 1.000 12.57274 ? 1624 ILE A HG21 1 
ATOM   2650 H  HG22 . ILE A 1 165 ? -7.42448  -5.94927  -12.17253 1.000 12.57274 ? 1624 ILE A HG22 1 
ATOM   2651 H  HG23 . ILE A 1 165 ? -7.23895  -6.08076  -10.60034 1.000 12.57274 ? 1624 ILE A HG23 1 
ATOM   2652 H  HD11 . ILE A 1 165 ? -11.55056 -6.45334  -9.66544  1.000 12.94546 ? 1624 ILE A HD11 1 
ATOM   2653 H  HD12 . ILE A 1 165 ? -11.44446 -5.93171  -11.16215 1.000 12.94546 ? 1624 ILE A HD12 1 
ATOM   2654 H  HD13 . ILE A 1 165 ? -10.53041 -7.13574  -10.67397 1.000 12.94546 ? 1624 ILE A HD13 1 
ATOM   2655 N  N    . LYS A 1 166 ? -7.23600  -2.77070  -12.80147 1.000 10.01939 ? 1625 LYS A N    1 
ATOM   2656 C  CA   A LYS A 1 166 ? -6.14830  -2.41107  -13.70387 0.389 10.37735 ? 1625 LYS A CA   1 
ATOM   2657 C  CA   B LYS A 1 166 ? -6.16641  -2.38602  -13.71774 0.611 10.25368 ? 1625 LYS A CA   1 
ATOM   2658 C  C    . LYS A 1 166 ? -5.18566  -1.43333  -13.03746 1.000 9.85893  ? 1625 LYS A C    1 
ATOM   2659 O  O    . LYS A 1 166 ? -3.97177  -1.58476  -13.15456 1.000 11.31684 ? 1625 LYS A O    1 
ATOM   2660 C  CB   A LYS A 1 166 ? -6.69668  -1.82283  -15.00524 0.389 11.51163 ? 1625 LYS A CB   1 
ATOM   2661 C  CB   B LYS A 1 166 ? -6.77823  -1.72317  -14.95548 0.611 11.69322 ? 1625 LYS A CB   1 
ATOM   2662 C  CG   A LYS A 1 166 ? -5.64046  -1.42198  -16.03075 0.389 11.98541 ? 1625 LYS A CG   1 
ATOM   2663 C  CG   B LYS A 1 166 ? -5.82248  -1.30264  -16.06664 0.611 11.99863 ? 1625 LYS A CG   1 
ATOM   2664 C  CD   A LYS A 1 166 ? -6.27937  -0.93256  -17.33487 0.389 12.58814 ? 1625 LYS A CD   1 
ATOM   2665 C  CD   B LYS A 1 166 ? -6.59177  -0.53661  -17.13628 0.611 14.36457 ? 1625 LYS A CD   1 
ATOM   2666 C  CE   A LYS A 1 166 ? -5.27355  -0.27849  -18.27640 0.389 15.21996 ? 1625 LYS A CE   1 
ATOM   2667 C  CE   B LYS A 1 166 ? -5.87477  -0.40515  -18.45124 0.611 15.18580 ? 1625 LYS A CE   1 
ATOM   2668 N  NZ   A LYS A 1 166 ? -4.47501  -1.30320  -19.00184 0.389 17.08597 ? 1625 LYS A NZ   1 
ATOM   2669 N  NZ   B LYS A 1 166 ? -6.76307  0.18195   -19.45889 0.611 16.74646 ? 1625 LYS A NZ   1 
ATOM   2670 H  H    A LYS A 1 166 ? -8.02020  -2.57952  -13.09827 0.389 12.02327 ? 1625 LYS A H    1 
ATOM   2671 H  H    B LYS A 1 166 ? -8.02356  -2.59028  -13.09610 0.611 12.02327 ? 1625 LYS A H    1 
ATOM   2672 H  HA   A LYS A 1 166 ? -5.65824  -3.21657  -13.93167 0.389 12.45282 ? 1625 LYS A HA   1 
ATOM   2673 H  HA   B LYS A 1 166 ? -5.67886  -3.17756  -13.99461 0.611 12.30442 ? 1625 LYS A HA   1 
ATOM   2674 H  HB2  A LYS A 1 166 ? -7.27034  -2.48427  -15.42275 0.389 13.81396 ? 1625 LYS A HB2  1 
ATOM   2675 H  HB2  B LYS A 1 166 ? -7.40785  -2.34809  -15.34784 0.611 14.03187 ? 1625 LYS A HB2  1 
ATOM   2676 H  HB3  A LYS A 1 166 ? -7.20899  -1.02772  -14.79022 0.389 13.81396 ? 1625 LYS A HB3  1 
ATOM   2677 H  HB3  B LYS A 1 166 ? -7.24251  -0.92221  -14.66597 0.611 14.03187 ? 1625 LYS A HB3  1 
ATOM   2678 H  HG2  A LYS A 1 166 ? -5.09794  -0.70384  -15.66903 0.389 14.38250 ? 1625 LYS A HG2  1 
ATOM   2679 H  HG2  B LYS A 1 166 ? -5.13090  -0.72653  -15.70511 0.611 14.39835 ? 1625 LYS A HG2  1 
ATOM   2680 H  HG3  A LYS A 1 166 ? -5.08270  -2.18913  -16.23391 0.389 14.38250 ? 1625 LYS A HG3  1 
ATOM   2681 H  HG3  B LYS A 1 166 ? -5.42206  -2.08822  -16.47089 0.611 14.39835 ? 1625 LYS A HG3  1 
ATOM   2682 H  HD2  A LYS A 1 166 ? -6.67421  -1.68855  -17.79690 0.389 15.10577 ? 1625 LYS A HD2  1 
ATOM   2683 H  HD2  B LYS A 1 166 ? -7.42834  -0.99756  -17.30531 0.611 17.23748 ? 1625 LYS A HD2  1 
ATOM   2684 H  HD3  A LYS A 1 166 ? -6.96345  -0.27747  -17.12564 0.389 15.10577 ? 1625 LYS A HD3  1 
ATOM   2685 H  HD3  B LYS A 1 166 ? -6.76700  0.35955   -16.80903 0.611 17.23748 ? 1625 LYS A HD3  1 
ATOM   2686 H  HE2  A LYS A 1 166 ? -5.74626  0.26097   -18.92942 0.389 18.26395 ? 1625 LYS A HE2  1 
ATOM   2687 H  HE2  B LYS A 1 166 ? -5.10249  0.17203   -18.34475 0.611 18.22297 ? 1625 LYS A HE2  1 
ATOM   2688 H  HE3  A LYS A 1 166 ? -4.66609  0.27762   -17.76393 0.389 18.26395 ? 1625 LYS A HE3  1 
ATOM   2689 H  HE3  B LYS A 1 166 ? -5.59419  -1.28149  -18.75817 0.611 18.22297 ? 1625 LYS A HE3  1 
ATOM   2690 H  HZ1  A LYS A 1 166 ? -3.90167  -0.90668  -19.55517 0.389 20.50316 ? 1625 LYS A HZ1  1 
ATOM   2691 H  HZ1  B LYS A 1 166 ? -7.47750  -0.33620  -19.57382 0.611 20.09575 ? 1625 LYS A HZ1  1 
ATOM   2692 H  HZ2  A LYS A 1 166 ? -4.01920  -1.80081  -18.42156 0.389 20.50316 ? 1625 LYS A HZ2  1 
ATOM   2693 H  HZ2  B LYS A 1 166 ? -7.03082  0.98884   -19.19557 0.611 20.09575 ? 1625 LYS A HZ2  1 
ATOM   2694 H  HZ3  A LYS A 1 166 ? -5.01405  -1.83099  -19.47403 0.389 20.50316 ? 1625 LYS A HZ3  1 
ATOM   2695 H  HZ3  B LYS A 1 166 ? -6.33423  0.25892   -20.23495 0.611 20.09575 ? 1625 LYS A HZ3  1 
ATOM   2696 N  N    . ALA A 1 167 ? -5.71999  -0.41967  -12.34050 1.000 10.70631 ? 1626 ALA A N    1 
ATOM   2697 C  CA   . ALA A 1 167 ? -4.85803  0.51962   -11.61865 1.000 11.13527 ? 1626 ALA A CA   1 
ATOM   2698 C  C    . ALA A 1 167 ? -4.06471  -0.17943  -10.53651 1.000 10.42216 ? 1626 ALA A C    1 
ATOM   2699 O  O    . ALA A 1 167 ? -2.88193  0.14235   -10.31436 1.000 12.05642 ? 1626 ALA A O    1 
ATOM   2700 C  CB   . ALA A 1 167 ? -5.74198  1.64831   -11.05732 1.000 11.60376 ? 1626 ALA A CB   1 
ATOM   2701 H  H    . ALA A 1 167 ? -6.56200  -0.25855  -12.27214 1.000 12.84757 ? 1626 ALA A H    1 
ATOM   2702 H  HA   . ALA A 1 167 ? -4.20567  0.91421   -12.21834 1.000 13.36233 ? 1626 ALA A HA   1 
ATOM   2703 H  HB1  . ALA A 1 167 ? -5.18274  2.27715   -10.57493 1.000 13.92451 ? 1626 ALA A HB1  1 
ATOM   2704 H  HB2  . ALA A 1 167 ? -6.18586  2.09759   -11.79354 1.000 13.92451 ? 1626 ALA A HB2  1 
ATOM   2705 H  HB3  . ALA A 1 167 ? -6.40128  1.26473   -10.45808 1.000 13.92451 ? 1626 ALA A HB3  1 
ATOM   2706 N  N    . ALA A 1 168 ? -4.69018  -1.11123  -9.81976  1.000 10.77211 ? 1627 ALA A N    1 
ATOM   2707 C  CA   . ALA A 1 168 ? -3.97592  -1.84855  -8.78844  1.000 11.48789 ? 1627 ALA A CA   1 
ATOM   2708 C  C    . ALA A 1 168 ? -2.84513  -2.69225  -9.37262  1.000 11.41953 ? 1627 ALA A C    1 
ATOM   2709 O  O    . ALA A 1 168 ? -1.71827  -2.73523  -8.83187  1.000 11.60639 ? 1627 ALA A O    1 
ATOM   2710 C  CB   . ALA A 1 168 ? -4.97925  -2.70791  -8.02348  1.000 11.42747 ? 1627 ALA A CB   1 
ATOM   2711 H  H    . ALA A 1 168 ? -5.51654  -1.33125  -9.91101  1.000 12.92653 ? 1627 ALA A H    1 
ATOM   2712 H  HA   . ALA A 1 168 ? -3.56218  -1.22799  -8.16826  1.000 13.78547 ? 1627 ALA A HA   1 
ATOM   2713 H  HB1  . ALA A 1 168 ? -4.51046  -3.20041  -7.33168  1.000 13.71296 ? 1627 ALA A HB1  1 
ATOM   2714 H  HB2  . ALA A 1 168 ? -5.64852  -2.13112  -7.62313  1.000 13.71296 ? 1627 ALA A HB2  1 
ATOM   2715 H  HB3  . ALA A 1 168 ? -5.40144  -3.32554  -8.64087  1.000 13.71296 ? 1627 ALA A HB3  1 
ATOM   2716 N  N    . LYS A 1 169 ? -3.09944  -3.34833  -10.49699 1.000 11.22481 ? 1628 LYS A N    1 
ATOM   2717 C  CA   . LYS A 1 169 ? -2.05010  -4.15999  -11.14245 1.000 11.66961 ? 1628 LYS A CA   1 
ATOM   2718 C  C    . LYS A 1 169 ? -0.89403  -3.26033  -11.63138 1.000 12.51443 ? 1628 LYS A C    1 
ATOM   2719 O  O    . LYS A 1 169 ? 0.28428   -3.64220  -11.55771 1.000 14.30929 ? 1628 LYS A O    1 
ATOM   2720 C  CB   . LYS A 1 169 ? -2.64224  -4.94530  -12.28708 1.000 11.90115 ? 1628 LYS A CB   1 
ATOM   2721 C  CG   . LYS A 1 169 ? -3.52169  -6.11531  -11.85216 1.000 10.81690 ? 1628 LYS A CG   1 
ATOM   2722 C  CD   . LYS A 1 169 ? -3.92777  -6.94315  -13.01559 1.000 11.98533 ? 1628 LYS A CD   1 
ATOM   2723 C  CE   . LYS A 1 169 ? -4.74766  -8.16400  -12.57639 1.000 10.71423 ? 1628 LYS A CE   1 
ATOM   2724 N  NZ   . LYS A 1 169 ? -5.05132  -9.07181  -13.68676 1.000 10.85370 ? 1628 LYS A NZ   1 
ATOM   2725 H  H    . LYS A 1 169 ? -3.85488  -3.34704  -10.90797 1.000 13.46977 ? 1628 LYS A H    1 
ATOM   2726 H  HA   . LYS A 1 169 ? -1.69041  -4.79920  -10.50767 1.000 14.00353 ? 1628 LYS A HA   1 
ATOM   2727 H  HB2  . LYS A 1 169 ? -3.18877  -4.34911  -12.82260 1.000 14.28138 ? 1628 LYS A HB2  1 
ATOM   2728 H  HB3  . LYS A 1 169 ? -1.91875  -5.30434  -12.82425 1.000 14.28138 ? 1628 LYS A HB3  1 
ATOM   2729 H  HG2  . LYS A 1 169 ? -3.02850  -6.67704  -11.23400 1.000 12.98028 ? 1628 LYS A HG2  1 
ATOM   2730 H  HG3  . LYS A 1 169 ? -4.32283  -5.77485  -11.42419 1.000 12.98028 ? 1628 LYS A HG3  1 
ATOM   2731 H  HD2  . LYS A 1 169 ? -4.47228  -6.40967  -13.61542 1.000 14.38239 ? 1628 LYS A HD2  1 
ATOM   2732 H  HD3  . LYS A 1 169 ? -3.13555  -7.25806  -13.47832 1.000 14.38239 ? 1628 LYS A HD3  1 
ATOM   2733 H  HE2  . LYS A 1 169 ? -4.24464  -8.66060  -11.91212 1.000 12.85707 ? 1628 LYS A HE2  1 
ATOM   2734 H  HE3  . LYS A 1 169 ? -5.58804  -7.86132  -12.19819 1.000 12.85707 ? 1628 LYS A HE3  1 
ATOM   2735 H  HZ1  . LYS A 1 169 ? -5.49587  -8.63639  -14.32308 1.000 13.02443 ? 1628 LYS A HZ1  1 
ATOM   2736 H  HZ2  . LYS A 1 169 ? -4.29679  -9.39481  -14.03094 1.000 13.02443 ? 1628 LYS A HZ2  1 
ATOM   2737 H  HZ3  . LYS A 1 169 ? -5.55046  -9.74970  -13.39793 1.000 13.02443 ? 1628 LYS A HZ3  1 
ATOM   2738 N  N    . ALA A 1 170 ? -1.20812  -2.04615  -12.09040 1.000 12.37498 ? 1629 ALA A N    1 
ATOM   2739 C  CA   . ALA A 1 170 ? -0.15204  -1.11678  -12.50894 1.000 13.02506 ? 1629 ALA A CA   1 
ATOM   2740 C  C    . ALA A 1 170 ? 0.74120   -0.69830  -11.34858 1.000 13.97776 ? 1629 ALA A C    1 
ATOM   2741 O  O    . ALA A 1 170 ? 1.92592   -0.38849  -11.57946 1.000 16.71472 ? 1629 ALA A O    1 
ATOM   2742 C  CB   . ALA A 1 170 ? -0.75709  0.11764   -13.17760 1.000 14.93044 ? 1629 ALA A CB   1 
ATOM   2743 H  H    . ALA A 1 170 ? -2.00798  -1.74007  -12.16877 1.000 14.84998 ? 1629 ALA A H    1 
ATOM   2744 H  HA   . ALA A 1 170 ? 0.40254   -1.57140  -13.16213 1.000 15.63007 ? 1629 ALA A HA   1 
ATOM   2745 H  HB1  . ALA A 1 170 ? -0.04125  0.71677   -13.44126 1.000 17.91653 ? 1629 ALA A HB1  1 
ATOM   2746 H  HB2  . ALA A 1 170 ? -1.25992  -0.16095  -13.95891 1.000 17.91653 ? 1629 ALA A HB2  1 
ATOM   2747 H  HB3  . ALA A 1 170 ? -1.34506  0.56211   -12.54702 1.000 17.91653 ? 1629 ALA A HB3  1 
ATOM   2748 N  N    A ARG A 1 171 ? 0.22811   -0.70679  -10.12382 0.310 13.88568 ? 1630 ARG A N    1 
ATOM   2749 N  N    B ARG A 1 171 ? 0.23506   -0.71330  -10.13426 0.690 12.62246 ? 1630 ARG A N    1 
ATOM   2750 C  CA   A ARG A 1 171 ? 1.01909   -0.45099  -8.92727  0.310 14.33571 ? 1630 ARG A CA   1 
ATOM   2751 C  CA   B ARG A 1 171 ? 0.98569   -0.46134  -8.91253  0.690 12.80136 ? 1630 ARG A CA   1 
ATOM   2752 C  C    A ARG A 1 171 ? 1.70196   -1.70540  -8.38906  0.310 14.33569 ? 1630 ARG A C    1 
ATOM   2753 C  C    B ARG A 1 171 ? 1.62711   -1.72627  -8.34517  0.690 13.82514 ? 1630 ARG A C    1 
ATOM   2754 O  O    A ARG A 1 171 ? 2.35836   -1.62237  -7.34585  0.310 15.11732 ? 1630 ARG A O    1 
ATOM   2755 O  O    B ARG A 1 171 ? 2.16880   -1.66613  -7.23479  0.690 15.78577 ? 1630 ARG A O    1 
ATOM   2756 C  CB   A ARG A 1 171 ? 0.16642   0.16709   -7.81039  0.310 15.84379 ? 1630 ARG A CB   1 
ATOM   2757 C  CB   B ARG A 1 171 ? 0.10347   0.21706   -7.86177  0.690 13.97519 ? 1630 ARG A CB   1 
ATOM   2758 C  CG   A ARG A 1 171 ? -0.32403  1.59649   -8.06049  0.310 17.75454 ? 1630 ARG A CG   1 
ATOM   2759 C  CG   B ARG A 1 171 ? -0.34584  1.64927   -8.23066  0.690 16.30178 ? 1630 ARG A CG   1 
ATOM   2760 C  CD   A ARG A 1 171 ? 0.81197   2.60545   -8.20318  0.310 20.39691 ? 1630 ARG A CD   1 
ATOM   2761 C  CD   B ARG A 1 171 ? 0.76246   2.64704   -8.04503  0.690 19.90998 ? 1630 ARG A CD   1 
ATOM   2762 N  NE   A ARG A 1 171 ? 1.79855   2.53475   -7.13323  0.310 22.23396 ? 1630 ARG A NE   1 
ATOM   2763 N  NE   B ARG A 1 171 ? 1.08667   2.76264   -6.63695  0.690 22.03926 ? 1630 ARG A NE   1 
ATOM   2764 C  CZ   A ARG A 1 171 ? 1.56531   2.77267   -5.84482  0.310 23.48147 ? 1630 ARG A CZ   1 
ATOM   2765 C  CZ   B ARG A 1 171 ? 2.18986   3.34625   -6.17998  0.690 25.50276 ? 1630 ARG A CZ   1 
ATOM   2766 N  NH1  A ARG A 1 171 ? 0.35521   3.05351   -5.39136  0.310 22.17351 ? 1630 ARG A NH1  1 
ATOM   2767 N  NH1  B ARG A 1 171 ? 3.04728   3.91557   -6.99926  0.690 25.67388 ? 1630 ARG A NH1  1 
ATOM   2768 N  NH2  A ARG A 1 171 ? 2.57890   2.72018   -4.98256  0.310 24.76320 ? 1630 ARG A NH2  1 
ATOM   2769 N  NH2  B ARG A 1 171 ? 2.44577   3.31727   -4.87103  0.690 27.56087 ? 1630 ARG A NH2  1 
ATOM   2770 H  H    A ARG A 1 171 ? -0.60062  -0.86290  -9.95521  0.310 16.66281 ? 1630 ARG A H    1 
ATOM   2771 H  H    B ARG A 1 171 ? -0.59420  -0.87703  -9.97578  0.690 15.14695 ? 1630 ARG A H    1 
ATOM   2772 H  HA   A ARG A 1 171 ? 1.69981   0.19826   -9.16393  0.310 17.20286 ? 1630 ARG A HA   1 
ATOM   2773 H  HA   B ARG A 1 171 ? 1.70136   0.16073   -9.11685  0.690 15.36163 ? 1630 ARG A HA   1 
ATOM   2774 H  HB2  A ARG A 1 171 ? -0.61877  -0.38840  -7.68467  0.310 19.01254 ? 1630 ARG A HB2  1 
ATOM   2775 H  HB2  B ARG A 1 171 ? -0.69601  -0.31801  -7.73749  0.690 16.77022 ? 1630 ARG A HB2  1 
ATOM   2776 H  HB3  A ARG A 1 171 ? 0.69537   0.18274   -6.99746  0.310 19.01254 ? 1630 ARG A HB3  1 
ATOM   2777 H  HB3  B ARG A 1 171 ? 0.59944   0.27066   -7.02988  0.690 16.77022 ? 1630 ARG A HB3  1 
ATOM   2778 H  HG2  A ARG A 1 171 ? -0.84140  1.61279   -8.88083  0.310 21.30545 ? 1630 ARG A HG2  1 
ATOM   2779 H  HG2  B ARG A 1 171 ? -0.61968  1.66927   -9.16099  0.690 19.56213 ? 1630 ARG A HG2  1 
ATOM   2780 H  HG3  A ARG A 1 171 ? -0.87718  1.87469   -7.31381  0.310 21.30545 ? 1630 ARG A HG3  1 
ATOM   2781 H  HG3  B ARG A 1 171 ? -1.08678  1.90907   -7.66108  0.690 19.56213 ? 1630 ARG A HG3  1 
ATOM   2782 H  HD2  A ARG A 1 171 ? 1.27245   2.44091   -9.04090  0.310 24.47629 ? 1630 ARG A HD2  1 
ATOM   2783 H  HD2  B ARG A 1 171 ? 1.55256   2.35223   -8.52434  0.690 23.89198 ? 1630 ARG A HD2  1 
ATOM   2784 H  HD3  A ARG A 1 171 ? 0.43721   3.50013   -8.20075  0.310 24.47629 ? 1630 ARG A HD3  1 
ATOM   2785 H  HD3  B ARG A 1 171 ? 0.48020   3.51521   -8.37291  0.690 23.89198 ? 1630 ARG A HD3  1 
ATOM   2786 H  HE   A ARG A 1 171 ? 2.60177   2.32056   -7.35360  0.310 26.68076 ? 1630 ARG A HE   1 
ATOM   2787 H  HE   B ARG A 1 171 ? 0.53411   2.43517   -6.06507  0.690 26.44711 ? 1630 ARG A HE   1 
ATOM   2788 H  HH11 A ARG A 1 171 ? -0.31060  3.08670   -5.93468  0.310 26.60821 ? 1630 ARG A HH11 1 
ATOM   2789 H  HH11 B ARG A 1 171 ? 3.75659   4.28907   -6.68783  0.690 30.80866 ? 1630 ARG A HH11 1 
ATOM   2790 H  HH12 A ARG A 1 171 ? 0.23407   3.20294   -4.55315  0.310 26.60821 ? 1630 ARG A HH12 1 
ATOM   2791 H  HH12 B ARG A 1 171 ? 2.89852   3.91427   -7.84630  0.690 30.80866 ? 1630 ARG A HH12 1 
ATOM   2792 H  HH21 A ARG A 1 171 ? 3.37112   2.53450   -5.26098  0.310 29.71584 ? 1630 ARG A HH21 1 
ATOM   2793 H  HH21 B ARG A 1 171 ? 1.90010   2.92446   -4.33480  0.690 33.07304 ? 1630 ARG A HH21 1 
ATOM   2794 H  HH22 A ARG A 1 171 ? 2.44122   2.87196   -4.14733  0.310 29.71584 ? 1630 ARG A HH22 1 
ATOM   2795 H  HH22 B ARG A 1 171 ? 3.15641   3.69140   -4.56344  0.690 33.07304 ? 1630 ARG A HH22 1 
ATOM   2796 N  N    . GLY A 1 172 ? 1.57525   -2.84991  -9.07003  1.000 14.01462 ? 1631 GLY A N    1 
ATOM   2797 C  CA   . GLY A 1 172 ? 2.25265   -4.06088  -8.62827  1.000 14.50938 ? 1631 GLY A CA   1 
ATOM   2798 C  C    . GLY A 1 172 ? 1.55842   -4.77516  -7.51523  1.000 14.51725 ? 1631 GLY A C    1 
ATOM   2799 O  O    . GLY A 1 172 ? 2.18852   -5.59886  -6.86045  1.000 15.36208 ? 1631 GLY A O    1 
ATOM   2800 H  H    . GLY A 1 172 ? 1.15500   -2.92948  -9.81613  1.000 16.81754 ? 1631 GLY A H    1 
ATOM   2801 H  HA2  . GLY A 1 172 ? 2.32339   -4.67219  -9.37807  1.000 17.41126 ? 1631 GLY A HA2  1 
ATOM   2802 H  HA3  . GLY A 1 172 ? 3.14425   -3.82879  -8.32483  1.000 17.41126 ? 1631 GLY A HA3  1 
ATOM   2803 N  N    . LEU A 1 173 ? 0.27091   -4.52878  -7.29515  1.000 12.33813 ? 1632 LEU A N    1 
ATOM   2804 C  CA   . LEU A 1 173 ? -0.40378  -5.18760  -6.20611  1.000 11.63803 ? 1632 LEU A CA   1 
ATOM   2805 C  C    . LEU A 1 173 ? -0.83925  -6.59071  -6.58846  1.000 10.99583 ? 1632 LEU A C    1 
ATOM   2806 O  O    . LEU A 1 173 ? -1.19534  -6.84234  -7.73648  1.000 11.48006 ? 1632 LEU A O    1 
ATOM   2807 C  CB   . LEU A 1 173 ? -1.61005  -4.38116  -5.78630  1.000 12.81190 ? 1632 LEU A CB   1 
ATOM   2808 C  CG   . LEU A 1 173 ? -1.25449  -2.94060  -5.33560  1.000 15.31212 ? 1632 LEU A CG   1 
ATOM   2809 C  CD1  . LEU A 1 173 ? -2.51493  -2.22097  -4.91417  1.000 16.39906 ? 1632 LEU A CD1  1 
ATOM   2810 C  CD2  . LEU A 1 173 ? -0.19641  -2.88215  -4.23411  1.000 17.52546 ? 1632 LEU A CD2  1 
ATOM   2811 H  H    . LEU A 1 173 ? -0.21759  -3.99325  -7.75793  1.000 14.80576 ? 1632 LEU A H    1 
ATOM   2812 H  HA   . LEU A 1 173 ? 0.20367   -5.26427  -5.45377  1.000 13.96563 ? 1632 LEU A HA   1 
ATOM   2813 H  HB2  . LEU A 1 173 ? -2.22122  -4.31761  -6.53685  1.000 15.37428 ? 1632 LEU A HB2  1 
ATOM   2814 H  HB3  . LEU A 1 173 ? -2.04313  -4.82899  -5.04280  1.000 15.37428 ? 1632 LEU A HB3  1 
ATOM   2815 H  HG   . LEU A 1 173 ? -0.85395  -2.48568  -6.09291  1.000 18.37455 ? 1632 LEU A HG   1 
ATOM   2816 H  HD11 . LEU A 1 173 ? -2.28462  -1.32480  -4.62307  1.000 19.67887 ? 1632 LEU A HD11 1 
ATOM   2817 H  HD12 . LEU A 1 173 ? -3.12153  -2.17764  -5.66986  1.000 19.67887 ? 1632 LEU A HD12 1 
ATOM   2818 H  HD13 . LEU A 1 173 ? -2.92877  -2.70937  -4.18540  1.000 19.67887 ? 1632 LEU A HD13 1 
ATOM   2819 H  HD21 . LEU A 1 173 ? -0.12985  -1.97098  -3.90817  1.000 21.03055 ? 1632 LEU A HD21 1 
ATOM   2820 H  HD22 . LEU A 1 173 ? -0.45963  -3.47350  -3.51166  1.000 21.03055 ? 1632 LEU A HD22 1 
ATOM   2821 H  HD23 . LEU A 1 173 ? 0.65610   -3.16576  -4.59976  1.000 21.03055 ? 1632 LEU A HD23 1 
ATOM   2822 N  N    . PRO A 1 174 ? -0.80777  -7.51110  -5.62648  1.000 10.65372 ? 1633 PRO A N    1 
ATOM   2823 C  CA   . PRO A 1 174 ? -1.13528  -8.91018  -5.93700  1.000 10.44842 ? 1633 PRO A CA   1 
ATOM   2824 C  C    . PRO A 1 174 ? -2.65009  -9.13330  -5.91790  1.000 9.43519  ? 1633 PRO A C    1 
ATOM   2825 O  O    . PRO A 1 174 ? -3.22883  -9.55441  -4.91122  1.000 10.79836 ? 1633 PRO A O    1 
ATOM   2826 C  CB   . PRO A 1 174 ? -0.42457  -9.68779  -4.82954  1.000 11.23259 ? 1633 PRO A CB   1 
ATOM   2827 C  CG   . PRO A 1 174 ? -0.40815  -8.76188  -3.64736  1.000 10.65105 ? 1633 PRO A CG   1 
ATOM   2828 C  CD   . PRO A 1 174 ? -0.25165  -7.38686  -4.26599  1.000 11.89583 ? 1633 PRO A CD   1 
ATOM   2829 H  HA   . PRO A 1 174 ? -0.76922  -9.18501  -6.79220  1.000 12.53811 ? 1633 PRO A HA   1 
ATOM   2830 H  HB2  . PRO A 1 174 ? -0.91744  -10.49853 -4.62785  1.000 13.47910 ? 1633 PRO A HB2  1 
ATOM   2831 H  HB3  . PRO A 1 174 ? 0.47760   -9.90885  -5.10907  1.000 13.47910 ? 1633 PRO A HB3  1 
ATOM   2832 H  HG2  . PRO A 1 174 ? -1.24075  -8.83231  -3.15470  1.000 12.78126 ? 1633 PRO A HG2  1 
ATOM   2833 H  HG3  . PRO A 1 174 ? 0.33975   -8.97263  -3.06674  1.000 12.78126 ? 1633 PRO A HG3  1 
ATOM   2834 H  HD2  . PRO A 1 174 ? -0.74881  -6.72813  -3.75628  1.000 14.27500 ? 1633 PRO A HD2  1 
ATOM   2835 H  HD3  . PRO A 1 174 ? 0.68513   -7.13820  -4.30498  1.000 14.27500 ? 1633 PRO A HD3  1 
ATOM   2836 N  N    . VAL A 1 175 ? -3.28802  -8.84558  -7.02157  1.000 9.41144  ? 1634 VAL A N    1 
ATOM   2837 C  CA   . VAL A 1 175 ? -4.73158  -9.04069  -7.20079  1.000 9.72196  ? 1634 VAL A CA   1 
ATOM   2838 C  C    . VAL A 1 175 ? -4.90146  -9.72641  -8.54188  1.000 9.10613  ? 1634 VAL A C    1 
ATOM   2839 O  O    . VAL A 1 175 ? -4.28456  -9.36088  -9.55075  1.000 10.24829 ? 1634 VAL A O    1 
ATOM   2840 C  CB   . VAL A 1 175 ? -5.47456  -7.69123  -7.13533  1.000 10.74850 ? 1634 VAL A CB   1 
ATOM   2841 C  CG1  . VAL A 1 175 ? -4.95967  -6.69052  -8.14109  1.000 13.01440 ? 1634 VAL A CG1  1 
ATOM   2842 C  CG2  . VAL A 1 175 ? -6.98360  -7.92972  -7.36221  1.000 11.42476 ? 1634 VAL A CG2  1 
ATOM   2843 H  H    . VAL A 1 175 ? -2.90417  -8.52151  -7.71959  1.000 11.29372 ? 1634 VAL A H    1 
ATOM   2844 H  HA   . VAL A 1 175 ? -5.11169  -9.60918  -6.51286  1.000 11.66636 ? 1634 VAL A HA   1 
ATOM   2845 H  HB   . VAL A 1 175 ? -5.31995  -7.30906  -6.25730  1.000 12.89820 ? 1634 VAL A HB   1 
ATOM   2846 H  HG11 . VAL A 1 175 ? -5.44051  -5.85541  -8.03025  1.000 15.61728 ? 1634 VAL A HG11 1 
ATOM   2847 H  HG12 . VAL A 1 175 ? -4.01208  -6.54927  -7.98936  1.000 15.61728 ? 1634 VAL A HG12 1 
ATOM   2848 H  HG13 . VAL A 1 175 ? -5.10323  -7.03874  -9.03498  1.000 15.61728 ? 1634 VAL A HG13 1 
ATOM   2849 H  HG21 . VAL A 1 175 ? -7.46217  -7.10190  -7.19918  1.000 13.70972 ? 1634 VAL A HG21 1 
ATOM   2850 H  HG22 . VAL A 1 175 ? -7.12363  -8.21795  -8.27776  1.000 13.70972 ? 1634 VAL A HG22 1 
ATOM   2851 H  HG23 . VAL A 1 175 ? -7.29064  -8.61561  -6.74887  1.000 13.70972 ? 1634 VAL A HG23 1 
ATOM   2852 N  N    . THR A 1 176 ? -5.79154  -10.72329 -8.56262  1.000 9.58774  ? 1635 THR A N    1 
ATOM   2853 C  CA   . THR A 1 176 ? -6.25064  -11.33106 -9.80029  1.000 9.10090  ? 1635 THR A CA   1 
ATOM   2854 C  C    . THR A 1 176 ? -7.77719  -11.24646 -9.83580  1.000 8.78240  ? 1635 THR A C    1 
ATOM   2855 O  O    . THR A 1 176 ? -8.41673  -10.91449 -8.83073  1.000 8.96659  ? 1635 THR A O    1 
ATOM   2856 C  CB   . THR A 1 176 ? -5.77906  -12.79901 -9.92748  1.000 9.47200  ? 1635 THR A CB   1 
ATOM   2857 O  OG1  . THR A 1 176 ? -6.18349  -13.51933 -8.76258  1.000 10.98523 ? 1635 THR A OG1  1 
ATOM   2858 C  CG2  . THR A 1 176 ? -4.25823  -12.85842 -10.06230 1.000 9.71140  ? 1635 THR A CG2  1 
ATOM   2859 H  H    . THR A 1 176 ? -6.14531  -11.06507 -7.85719  1.000 11.50528 ? 1635 THR A H    1 
ATOM   2860 H  HA   . THR A 1 176 ? -5.88596  -10.85185 -10.56073 1.000 10.92108 ? 1635 THR A HA   1 
ATOM   2861 H  HB   . THR A 1 176 ? -6.16949  -13.20704 -10.71614 1.000 11.36640 ? 1635 THR A HB   1 
ATOM   2862 H  HG1  . THR A 1 176 ? -5.94467  -14.32232 -8.82399  1.000 13.18228 ? 1635 THR A HG1  1 
ATOM   2863 H  HG21 . THR A 1 176 ? -3.96805  -13.78051 -10.14248 1.000 11.65368 ? 1635 THR A HG21 1 
ATOM   2864 H  HG22 . THR A 1 176 ? -3.97577  -12.36978 -10.85120 1.000 11.65368 ? 1635 THR A HG22 1 
ATOM   2865 H  HG23 . THR A 1 176 ? -3.84024  -12.46365 -9.28106  1.000 11.65368 ? 1635 THR A HG23 1 
ATOM   2866 N  N    . CYS A 1 177 ? -8.33458  -11.58091 -10.98748 1.000 9.16927  ? 1636 CYS A N    1 
ATOM   2867 C  CA   . CYS A 1 177 ? -9.79312  -11.51195 -11.10114 1.000 8.47450  ? 1636 CYS A CA   1 
ATOM   2868 C  C    . CYS A 1 177 ? -10.27972 -12.47413 -12.18016 1.000 8.20605  ? 1636 CYS A C    1 
ATOM   2869 O  O    . CYS A 1 177 ? -9.53493  -12.99889 -13.02997 1.000 8.66917  ? 1636 CYS A O    1 
ATOM   2870 C  CB   . CYS A 1 177 ? -10.23117 -10.07616 -11.41152 1.000 9.55878  ? 1636 CYS A CB   1 
ATOM   2871 S  SG   . CYS A 1 177 ? -9.84361  -9.47118  -13.06336 1.000 10.54564 ? 1636 CYS A SG   1 
ATOM   2872 H  H    . CYS A 1 177 ? -7.91341  -11.84051 -11.69091 1.000 11.00312 ? 1636 CYS A H    1 
ATOM   2873 H  HA   . CYS A 1 177 ? -10.19184 -11.79940 -10.26490 1.000 10.16940 ? 1636 CYS A HA   1 
ATOM   2874 H  HB2  . CYS A 1 177 ? -11.19396 -10.02370 -11.30578 1.000 11.47053 ? 1636 CYS A HB2  1 
ATOM   2875 H  HB3  . CYS A 1 177 ? -9.79522  -9.48322  -10.77965 1.000 11.47053 ? 1636 CYS A HB3  1 
ATOM   2876 H  HG   . CYS A 1 177 ? -10.23387 -8.34117  -13.16710 1.000 12.65477 ? 1636 CYS A HG   1 
ATOM   2877 N  N    . GLU A 1 178 ? -11.59340 -12.69236 -12.16785 1.000 8.24805  ? 1637 GLU A N    1 
ATOM   2878 C  CA   . GLU A 1 178 ? -12.28316 -13.48865 -13.17497 1.000 8.05343  ? 1637 GLU A CA   1 
ATOM   2879 C  C    . GLU A 1 178 ? -13.50619 -12.71799 -13.65168 1.000 8.23761  ? 1637 GLU A C    1 
ATOM   2880 O  O    . GLU A 1 178 ? -14.01657 -11.82632 -12.96469 1.000 9.31135  ? 1637 GLU A O    1 
ATOM   2881 C  CB   . GLU A 1 178 ? -12.76723 -14.81989 -12.56013 1.000 9.35345  ? 1637 GLU A CB   1 
ATOM   2882 C  CG   . GLU A 1 178 ? -13.93518 -14.61816 -11.57373 1.000 8.86925  ? 1637 GLU A CG   1 
ATOM   2883 C  CD   . GLU A 1 178 ? -14.19919 -15.67257 -10.53242 1.000 9.25091  ? 1637 GLU A CD   1 
ATOM   2884 O  OE1  . GLU A 1 178 ? -13.24790 -16.40707 -10.15160 1.000 9.69563  ? 1637 GLU A OE1  1 
ATOM   2885 O  OE2  . GLU A 1 178 ? -15.36329 -15.72598 -10.05351 1.000 10.54570 ? 1637 GLU A OE2  1 
ATOM   2886 H  H    . GLU A 1 178 ? -12.12169 -12.37872 -11.56607 1.000 9.89766  ? 1637 GLU A H    1 
ATOM   2887 H  HA   . GLU A 1 178 ? -11.69368 -13.66194 -13.92556 1.000 9.66411  ? 1637 GLU A HA   1 
ATOM   2888 H  HB2  . GLU A 1 178 ? -13.06973 -15.40643 -13.27102 1.000 11.22414 ? 1637 GLU A HB2  1 
ATOM   2889 H  HB3  . GLU A 1 178 ? -12.03311 -15.23288 -12.07909 1.000 11.22414 ? 1637 GLU A HB3  1 
ATOM   2890 H  HG2  . GLU A 1 178 ? -13.77077 -13.79287 -11.09129 1.000 10.64310 ? 1637 GLU A HG2  1 
ATOM   2891 H  HG3  . GLU A 1 178 ? -14.74869 -14.54054 -12.09631 1.000 10.64310 ? 1637 GLU A HG3  1 
ATOM   2892 N  N    . VAL A 1 179 ? -13.98413 -13.11220 -14.81657 1.000 8.26393  ? 1638 VAL A N    1 
ATOM   2893 C  CA   . VAL A 1 179 ? -15.19630 -12.57060 -15.42359 1.000 9.12194  ? 1638 VAL A CA   1 
ATOM   2894 C  C    . VAL A 1 179 ? -16.08240 -13.71952 -15.89839 1.000 9.48771  ? 1638 VAL A C    1 
ATOM   2895 O  O    . VAL A 1 179 ? -15.57317 -14.69845 -16.48158 1.000 9.22981  ? 1638 VAL A O    1 
ATOM   2896 C  CB   . VAL A 1 179 ? -14.86858 -11.59484 -16.58945 1.000 9.38771  ? 1638 VAL A CB   1 
ATOM   2897 C  CG1  . VAL A 1 179 ? -16.10933 -11.17296 -17.35145 1.000 10.21149 ? 1638 VAL A CG1  1 
ATOM   2898 C  CG2  . VAL A 1 179 ? -14.13052 -10.38355 -16.03054 1.000 9.54823  ? 1638 VAL A CG2  1 
ATOM   2899 H  H    . VAL A 1 179 ? -13.61138 -13.71839 -15.29946 1.000 9.91672  ? 1638 VAL A H    1 
ATOM   2900 H  HA   . VAL A 1 179 ? -15.69301 -12.08060 -14.74973 1.000 10.94632 ? 1638 VAL A HA   1 
ATOM   2901 H  HB   . VAL A 1 179 ? -14.30219 -12.05199 -17.23064 1.000 11.26526 ? 1638 VAL A HB   1 
ATOM   2902 H  HG11 . VAL A 1 179 ? -15.88416 -10.43281 -17.93658 1.000 12.25379 ? 1638 VAL A HG11 1 
ATOM   2903 H  HG12 . VAL A 1 179 ? -16.42845 -11.92397 -17.87589 1.000 12.25379 ? 1638 VAL A HG12 1 
ATOM   2904 H  HG13 . VAL A 1 179 ? -16.79080 -10.89844 -16.71810 1.000 12.25379 ? 1638 VAL A HG13 1 
ATOM   2905 H  HG21 . VAL A 1 179 ? -14.00406 -9.73532  -16.74097 1.000 11.45788 ? 1638 VAL A HG21 1 
ATOM   2906 H  HG22 . VAL A 1 179 ? -14.65905 -9.99330  -15.31691 1.000 11.45788 ? 1638 VAL A HG22 1 
ATOM   2907 H  HG23 . VAL A 1 179 ? -13.26980 -10.66930 -15.68642 1.000 11.45788 ? 1638 VAL A HG23 1 
ATOM   2908 N  N    . ALA A 1 180 ? -17.37978 -13.59796 -15.69915 1.000 9.41404  ? 1639 ALA A N    1 
ATOM   2909 C  CA   . ALA A 1 180 ? -18.39204 -14.61403 -16.05928 1.000 9.11926  ? 1639 ALA A CA   1 
ATOM   2910 C  C    . ALA A 1 180 ? -18.99075 -14.26768 -17.42083 1.000 9.31141  ? 1639 ALA A C    1 
ATOM   2911 O  O    . ALA A 1 180 ? -19.05933 -13.10773 -17.81536 1.000 10.24833 ? 1639 ALA A O    1 
ATOM   2912 C  CB   . ALA A 1 180 ? -19.48735 -14.62549 -14.98920 1.000 10.14307 ? 1639 ALA A CB   1 
ATOM   2913 H  H    . ALA A 1 180 ? -17.73574 -12.90354 -15.33767 1.000 11.29685 ? 1639 ALA A H    1 
ATOM   2914 H  HA   . ALA A 1 180 ? -18.00885 -15.50353 -16.11257 1.000 10.94311 ? 1639 ALA A HA   1 
ATOM   2915 H  HB1  . ALA A 1 180 ? -20.12805 -15.32243 -15.20055 1.000 12.17169 ? 1639 ALA A HB1  1 
ATOM   2916 H  HB2  . ALA A 1 180 ? -19.08268 -14.79922 -14.12493 1.000 12.17169 ? 1639 ALA A HB2  1 
ATOM   2917 H  HB3  . ALA A 1 180 ? -19.92897 -13.76190 -14.98007 1.000 12.17169 ? 1639 ALA A HB3  1 
ATOM   2918 N  N    . PRO A 1 181 ? -19.43942 -15.28606 -18.13395 1.000 9.85099  ? 1640 PRO A N    1 
ATOM   2919 C  CA   . PRO A 1 181 ? -19.85639 -15.07154 -19.50901 1.000 10.23258 ? 1640 PRO A CA   1 
ATOM   2920 C  C    . PRO A 1 181 ? -21.04359 -14.12378 -19.63032 1.000 9.83519  ? 1640 PRO A C    1 
ATOM   2921 O  O    . PRO A 1 181 ? -21.12713 -13.40388 -20.61779 1.000 10.42200 ? 1640 PRO A O    1 
ATOM   2922 C  CB   . PRO A 1 181 ? -20.23096 -16.48173 -20.02535 1.000 12.48020 ? 1640 PRO A CB   1 
ATOM   2923 C  CG   . PRO A 1 181 ? -19.56768 -17.36263 -19.14758 1.000 14.87240 ? 1640 PRO A CG   1 
ATOM   2924 C  CD   . PRO A 1 181 ? -19.35867 -16.73264 -17.80957 1.000 11.59860 ? 1640 PRO A CD   1 
ATOM   2925 H  HA   . PRO A 1 181 ? -19.10139 -14.73879 -20.01907 1.000 12.27910 ? 1640 PRO A HA   1 
ATOM   2926 H  HB2  . PRO A 1 181 ? -21.19209 -16.60634 -19.98531 1.000 14.97625 ? 1640 PRO A HB2  1 
ATOM   2927 H  HB3  . PRO A 1 181 ? -19.91928 -16.59605 -20.93677 1.000 14.97625 ? 1640 PRO A HB3  1 
ATOM   2928 H  HG2  . PRO A 1 181 ? -20.10990 -18.16083 -19.04868 1.000 17.84688 ? 1640 PRO A HG2  1 
ATOM   2929 H  HG3  . PRO A 1 181 ? -18.70863 -17.59113 -19.53581 1.000 17.84688 ? 1640 PRO A HG3  1 
ATOM   2930 H  HD2  . PRO A 1 181 ? -20.05663 -16.99158 -17.18771 1.000 13.91832 ? 1640 PRO A HD2  1 
ATOM   2931 H  HD3  . PRO A 1 181 ? -18.48896 -16.96210 -17.44647 1.000 13.91832 ? 1640 PRO A HD3  1 
ATOM   2932 N  N    . HIS A 1 182 ? -21.97727 -14.14867 -18.67515 1.000 9.51147  ? 1641 HIS A N    1 
ATOM   2933 C  CA   . HIS A 1 182 ? -23.09984 -13.24412 -18.80855 1.000 10.08782 ? 1641 HIS A CA   1 
ATOM   2934 C  C    . HIS A 1 182 ? -22.69428 -11.77812 -18.76354 1.000 10.38252 ? 1641 HIS A C    1 
ATOM   2935 O  O    . HIS A 1 182 ? -23.42768 -10.94262 -19.30559 1.000 11.52480 ? 1641 HIS A O    1 
ATOM   2936 C  CB   . HIS A 1 182 ? -24.15493 -13.51114 -17.73622 1.000 10.42466 ? 1641 HIS A CB   1 
ATOM   2937 C  CG   . HIS A 1 182 ? -23.65037 -13.87644 -16.38803 1.000 10.02986 ? 1641 HIS A CG   1 
ATOM   2938 N  ND1  . HIS A 1 182 ? -23.11436 -15.13503 -16.10178 1.000 9.98255  ? 1641 HIS A ND1  1 
ATOM   2939 C  CD2  . HIS A 1 182 ? -23.66978 -13.18943 -15.22399 1.000 9.76671  ? 1641 HIS A CD2  1 
ATOM   2940 C  CE1  . HIS A 1 182 ? -22.85223 -15.18794 -14.81184 1.000 9.51406  ? 1641 HIS A CE1  1 
ATOM   2941 N  NE2  . HIS A 1 182 ? -23.16133 -14.01340 -14.24903 1.000 9.57197  ? 1641 HIS A NE2  1 
ATOM   2942 H  H    . HIS A 1 182 ? -21.97672 -14.65556 -17.98041 1.000 11.41376 ? 1641 HIS A H    1 
ATOM   2943 H  HA   . HIS A 1 182 ? -23.50339 -13.41765 -19.67338 1.000 12.10538 ? 1641 HIS A HA   1 
ATOM   2944 H  HB2  . HIS A 1 182 ? -24.68881 -12.70800 -17.63213 1.000 12.50959 ? 1641 HIS A HB2  1 
ATOM   2945 H  HB3  . HIS A 1 182 ? -24.71363 -14.24398 -18.03902 1.000 12.50959 ? 1641 HIS A HB3  1 
ATOM   2946 H  HD2  . HIS A 1 182 ? -23.97211 -12.31806 -15.10480 1.000 11.72005 ? 1641 HIS A HD2  1 
ATOM   2947 H  HE1  . HIS A 1 182 ? -22.50672 -15.92541 -14.36279 1.000 11.41687 ? 1641 HIS A HE1  1 
ATOM   2948 H  HE2  . HIS A 1 182 ? -23.05924 -13.80956 -13.41979 1.000 11.48637 ? 1641 HIS A HE2  1 
ATOM   2949 N  N    . HIS A 1 183 ? -21.55697 -11.43482 -18.15229 1.000 9.93520  ? 1642 HIS A N    1 
ATOM   2950 C  CA   . HIS A 1 183 ? -21.10862 -10.02328 -18.13849 1.000 8.82451  ? 1642 HIS A CA   1 
ATOM   2951 C  C    . HIS A 1 183 ? -20.31843 -9.65995  -19.36879 1.000 8.71400  ? 1642 HIS A C    1 
ATOM   2952 O  O    . HIS A 1 183 ? -20.03470 -8.48255  -19.57960 1.000 11.25632 ? 1642 HIS A O    1 
ATOM   2953 C  CB   . HIS A 1 183 ? -20.38945 -9.74463  -16.82223 1.000 8.69550  ? 1642 HIS A CB   1 
ATOM   2954 C  CG   . HIS A 1 183 ? -21.25377 -9.88016  -15.62960 1.000 7.77182  ? 1642 HIS A CG   1 
ATOM   2955 N  ND1  . HIS A 1 183 ? -20.97954 -10.73537 -14.58209 1.000 9.01137  ? 1642 HIS A ND1  1 
ATOM   2956 C  CD2  . HIS A 1 183 ? -22.44547 -9.27150  -15.33045 1.000 10.02196 ? 1642 HIS A CD2  1 
ATOM   2957 C  CE1  . HIS A 1 183 ? -21.94081 -10.64314 -13.68280 1.000 10.06413 ? 1642 HIS A CE1  1 
ATOM   2958 N  NE2  . HIS A 1 183 ? -22.84820 -9.74776  -14.11970 1.000 10.38518 ? 1642 HIS A NE2  1 
ATOM   2959 H  H    . HIS A 1 183 ? -21.03408 -11.98323 -17.74556 1.000 11.92224 ? 1642 HIS A H    1 
ATOM   2960 H  HA   . HIS A 1 183 ? -21.85727 -9.40655  -18.14600 1.000 10.58942 ? 1642 HIS A HA   1 
ATOM   2961 H  HB2  . HIS A 1 183 ? -19.65584 -10.37232 -16.72887 1.000 10.43461 ? 1642 HIS A HB2  1 
ATOM   2962 H  HB3  . HIS A 1 183 ? -20.04895 -8.83652  -16.83922 1.000 10.43461 ? 1642 HIS A HB3  1 
ATOM   2963 H  HD2  . HIS A 1 183 ? -22.89480 -8.64965  -15.85609 1.000 12.02635 ? 1642 HIS A HD2  1 
ATOM   2964 H  HE1  . HIS A 1 183 ? -21.98465 -11.11590 -12.88312 1.000 12.07695 ? 1642 HIS A HE1  1 
ATOM   2965 H  HE2  . HIS A 1 183 ? -23.56358 -9.51539  -13.70277 1.000 12.46221 ? 1642 HIS A HE2  1 
ATOM   2966 N  N    . LEU A 1 184 ? -20.02236 -10.63408 -20.24949 1.000 9.92204  ? 1643 LEU A N    1 
ATOM   2967 C  CA   . LEU A 1 184 ? -19.43871 -10.38603 -21.56205 1.000 10.30101 ? 1643 LEU A CA   1 
ATOM   2968 C  C    . LEU A 1 184 ? -20.44512 -10.45610 -22.70451 1.000 10.44580 ? 1643 LEU A C    1 
ATOM   2969 O  O    . LEU A 1 184 ? -20.17188 -9.93345  -23.77773 1.000 11.69846 ? 1643 LEU A O    1 
ATOM   2970 C  CB   . LEU A 1 184 ? -18.33196 -11.43641 -21.80817 1.000 10.75106 ? 1643 LEU A CB   1 
ATOM   2971 C  CG   . LEU A 1 184 ? -17.14224 -11.30633 -20.88435 1.000 11.30909 ? 1643 LEU A CG   1 
ATOM   2972 C  CD1  . LEU A 1 184 ? -16.23966 -12.54009 -21.02317 1.000 13.76184 ? 1643 LEU A CD1  1 
ATOM   2973 C  CD2  . LEU A 1 184 ? -16.34296 -10.06228 -21.22553 1.000 12.59859 ? 1643 LEU A CD2  1 
ATOM   2974 H  H    . LEU A 1 184 ? -20.15781 -11.46951 -20.09682 1.000 11.90645 ? 1643 LEU A H    1 
ATOM   2975 H  HA   . LEU A 1 184 ? -19.05170 -9.49679  -21.58136 1.000 12.36121 ? 1643 LEU A HA   1 
ATOM   2976 H  HB2  . LEU A 1 184 ? -18.70987 -12.32061 -21.68057 1.000 12.90128 ? 1643 LEU A HB2  1 
ATOM   2977 H  HB3  . LEU A 1 184 ? -18.01100 -11.34102 -22.71854 1.000 12.90128 ? 1643 LEU A HB3  1 
ATOM   2978 H  HG   . LEU A 1 184 ? -17.45609 -11.23673 -19.96917 1.000 13.57090 ? 1643 LEU A HG   1 
ATOM   2979 H  HD11 . LEU A 1 184 ? -15.48053 -12.44472 -20.42691 1.000 16.51421 ? 1643 LEU A HD11 1 
ATOM   2980 H  HD12 . LEU A 1 184 ? -16.74826 -13.33162 -20.78716 1.000 16.51421 ? 1643 LEU A HD12 1 
ATOM   2981 H  HD13 . LEU A 1 184 ? -15.93309 -12.60543 -21.94113 1.000 16.51421 ? 1643 LEU A HD13 1 
ATOM   2982 H  HD21 . LEU A 1 184 ? -15.52965 -10.05465 -20.69697 1.000 15.11830 ? 1643 LEU A HD21 1 
ATOM   2983 H  HD22 . LEU A 1 184 ? -16.12338 -10.07722 -22.17023 1.000 15.11830 ? 1643 LEU A HD22 1 
ATOM   2984 H  HD23 . LEU A 1 184 ? -16.87685 -9.27832  -21.02238 1.000 15.11830 ? 1643 LEU A HD23 1 
ATOM   2985 N  N    . PHE A 1 185 ? -21.56107 -11.20448 -22.52107 1.000 11.68534 ? 1644 PHE A N    1 
ATOM   2986 C  CA   . PHE A 1 185 ? -22.48053 -11.54317 -23.59084 1.000 11.54065 ? 1644 PHE A CA   1 
ATOM   2987 C  C    . PHE A 1 185 ? -23.92673 -11.13455 -23.36301 1.000 11.03273 ? 1644 PHE A C    1 
ATOM   2988 O  O    . PHE A 1 185 ? -24.73472 -11.35482 -24.26794 1.000 13.86445 ? 1644 PHE A O    1 
ATOM   2989 C  CB   . PHE A 1 185 ? -22.40859 -13.07234 -23.86338 1.000 12.39858 ? 1644 PHE A CB   1 
ATOM   2990 C  CG   . PHE A 1 185 ? -21.05478 -13.53302 -24.37318 1.000 12.15654 ? 1644 PHE A CG   1 
ATOM   2991 C  CD1  . PHE A 1 185 ? -20.63952 -13.23210 -25.63658 1.000 14.04081 ? 1644 PHE A CD1  1 
ATOM   2992 C  CD2  . PHE A 1 185 ? -20.23122 -14.23516 -23.54969 1.000 12.20127 ? 1644 PHE A CD2  1 
ATOM   2993 C  CE1  . PHE A 1 185 ? -19.38914 -13.63712 -26.10414 1.000 14.61452 ? 1644 PHE A CE1  1 
ATOM   2994 C  CE2  . PHE A 1 185 ? -18.98199 -14.65267 -24.01787 1.000 12.28285 ? 1644 PHE A CE2  1 
ATOM   2995 C  CZ   . PHE A 1 185 ? -18.58888 -14.36200 -25.28319 1.000 12.97506 ? 1644 PHE A CZ   1 
ATOM   2996 H  H    . PHE A 1 185 ? -21.79723 -11.52731 -21.75975 1.000 14.02241 ? 1644 PHE A H    1 
ATOM   2997 H  HA   . PHE A 1 185 ? -22.19724 -11.06282 -24.38450 1.000 13.84878 ? 1644 PHE A HA   1 
ATOM   2998 H  HB2  . PHE A 1 185 ? -22.59212 -13.54642 -23.03726 1.000 14.87829 ? 1644 PHE A HB2  1 
ATOM   2999 H  HB3  . PHE A 1 185 ? -23.07214 -13.30252 -24.53242 1.000 14.87829 ? 1644 PHE A HB3  1 
ATOM   3000 H  HD1  . PHE A 1 185 ? -21.20088 -12.74733 -26.19762 1.000 16.84898 ? 1644 PHE A HD1  1 
ATOM   3001 H  HD2  . PHE A 1 185 ? -20.49716 -14.43607 -22.68146 1.000 14.64152 ? 1644 PHE A HD2  1 
ATOM   3002 H  HE1  . PHE A 1 185 ? -19.10950 -13.41428 -26.96265 1.000 17.53743 ? 1644 PHE A HE1  1 
ATOM   3003 H  HE2  . PHE A 1 185 ? -18.41621 -15.13329 -23.45769 1.000 14.73942 ? 1644 PHE A HE2  1 
ATOM   3004 H  HZ   . PHE A 1 185 ? -17.76396 -14.66216 -25.59031 1.000 15.57008 ? 1644 PHE A HZ   1 
ATOM   3005 N  N    . LEU A 1 186 ? -24.24871 -10.55079 -22.22124 1.000 11.38272 ? 1645 LEU A N    1 
ATOM   3006 C  CA   . LEU A 1 186 ? -25.56419 -9.99033  -21.93766 1.000 11.83013 ? 1645 LEU A CA   1 
ATOM   3007 C  C    . LEU A 1 186 ? -25.36017 -8.60703  -21.32654 1.000 12.10910 ? 1645 LEU A C    1 
ATOM   3008 O  O    . LEU A 1 186 ? -24.28773 -8.29636  -20.78930 1.000 12.36441 ? 1645 LEU A O    1 
ATOM   3009 C  CB   . LEU A 1 186 ? -26.30954 -10.87887 -20.92514 1.000 12.15381 ? 1645 LEU A CB   1 
ATOM   3010 C  CG   . LEU A 1 186 ? -26.75618 -12.25646 -21.43766 1.000 12.40658 ? 1645 LEU A CG   1 
ATOM   3011 C  CD1  . LEU A 1 186 ? -27.22265 -13.12582 -20.26343 1.000 13.05657 ? 1645 LEU A CD1  1 
ATOM   3012 C  CD2  . LEU A 1 186 ? -27.83711 -12.17788 -22.50917 1.000 13.89084 ? 1645 LEU A CD2  1 
ATOM   3013 H  H    . LEU A 1 186 ? -23.70042 -10.46174 -21.56469 1.000 13.65927 ? 1645 LEU A H    1 
ATOM   3014 H  HA   . LEU A 1 186 ? -26.09246 -9.91354  -22.74756 1.000 14.19615 ? 1645 LEU A HA   1 
ATOM   3015 H  HB2  . LEU A 1 186 ? -25.72339 -11.03074 -20.16734 1.000 14.58458 ? 1645 LEU A HB2  1 
ATOM   3016 H  HB3  . LEU A 1 186 ? -27.10699 -10.40690 -20.63840 1.000 14.58458 ? 1645 LEU A HB3  1 
ATOM   3017 H  HG   . LEU A 1 186 ? -25.99000 -12.67229 -21.86305 1.000 14.88790 ? 1645 LEU A HG   1 
ATOM   3018 H  HD11 . LEU A 1 186 ? -27.51040 -13.98756 -20.60327 1.000 15.66788 ? 1645 LEU A HD11 1 
ATOM   3019 H  HD12 . LEU A 1 186 ? -26.48464 -13.24376 -19.64510 1.000 15.66788 ? 1645 LEU A HD12 1 
ATOM   3020 H  HD13 . LEU A 1 186 ? -27.96107 -12.68315 -19.81656 1.000 15.66788 ? 1645 LEU A HD13 1 
ATOM   3021 H  HD21 . LEU A 1 186 ? -28.08073 -13.07731 -22.77854 1.000 16.66901 ? 1645 LEU A HD21 1 
ATOM   3022 H  HD22 . LEU A 1 186 ? -28.61095 -11.72086 -22.14419 1.000 16.66901 ? 1645 LEU A HD22 1 
ATOM   3023 H  HD23 . LEU A 1 186 ? -27.49160 -11.68661 -23.27087 1.000 16.66901 ? 1645 LEU A HD23 1 
ATOM   3024 N  N    . SER A 1 187 ? -26.41625 -7.79575  -21.38449 1.000 12.66181 ? 1646 SER A N    1 
ATOM   3025 C  CA   . SER A 1 187 ? -26.34367 -6.43913  -20.83850 1.000 13.05396 ? 1646 SER A CA   1 
ATOM   3026 C  C    . SER A 1 187 ? -27.75891 -5.98051  -20.50104 1.000 13.04347 ? 1646 SER A C    1 
ATOM   3027 O  O    . SER A 1 187 ? -28.72656 -6.72564  -20.65714 1.000 13.77507 ? 1646 SER A O    1 
ATOM   3028 C  CB   . SER A 1 187 ? -25.77320 -5.48134  -21.86655 1.000 13.35399 ? 1646 SER A CB   1 
ATOM   3029 O  OG   . SER A 1 187 ? -26.72658 -5.18735  -22.90002 1.000 14.96992 ? 1646 SER A OG   1 
ATOM   3030 H  H    . SER A 1 187 ? -27.17564 -8.00433  -21.73006 1.000 15.19417 ? 1646 SER A H    1 
ATOM   3031 H  HA   . SER A 1 187 ? -25.79349 -6.46218  -20.03996 1.000 15.66476 ? 1646 SER A HA   1 
ATOM   3032 H  HB2  . SER A 1 187 ? -25.52852 -4.65459  -21.42213 1.000 16.02479 ? 1646 SER A HB2  1 
ATOM   3033 H  HB3  . SER A 1 187 ? -24.98921 -5.88578  -22.26990 1.000 16.02479 ? 1646 SER A HB3  1 
ATOM   3034 H  HG   . SER A 1 187 ? -26.93957 -5.89264  -23.30350 1.000 17.96390 ? 1646 SER A HG   1 
ATOM   3035 N  N    . HIS A 1 188 ? -27.88082 -4.73148  -20.09631 1.000 14.49889 ? 1647 HIS A N    1 
ATOM   3036 C  CA   . HIS A 1 188 ? -29.20927 -4.11849  -19.90909 1.000 16.01746 ? 1647 HIS A CA   1 
ATOM   3037 C  C    . HIS A 1 188 ? -30.11065 -4.32950  -21.09372 1.000 16.70708 ? 1647 HIS A C    1 
ATOM   3038 O  O    . HIS A 1 188 ? -31.34442 -4.38718  -20.92856 1.000 17.35968 ? 1647 HIS A O    1 
ATOM   3039 C  CB   . HIS A 1 188 ? -29.05998 -2.60059  -19.70153 1.000 16.05695 ? 1647 HIS A CB   1 
ATOM   3040 C  CG   . HIS A 1 188 ? -28.37740 -2.22873  -18.42791 1.000 16.35176 ? 1647 HIS A CG   1 
ATOM   3041 N  ND1  . HIS A 1 188 ? -27.94085 -0.94637  -18.15393 1.000 17.84661 ? 1647 HIS A ND1  1 
ATOM   3042 C  CD2  . HIS A 1 188 ? -28.00825 -2.98656  -17.36676 1.000 17.16493 ? 1647 HIS A CD2  1 
ATOM   3043 C  CE1  . HIS A 1 188 ? -27.37860 -0.92841  -16.95728 1.000 18.10451 ? 1647 HIS A CE1  1 
ATOM   3044 N  NE2  . HIS A 1 188 ? -27.40101 -2.15106  -16.45396 1.000 17.33081 ? 1647 HIS A NE2  1 
ATOM   3045 H  H    . HIS A 1 188 ? -27.22201 -4.20751  -19.92014 1.000 17.39867 ? 1647 HIS A H    1 
ATOM   3046 H  HA   . HIS A 1 188 ? -29.61124 -4.52626  -19.12612 1.000 19.22095 ? 1647 HIS A HA   1 
ATOM   3047 H  HB2  . HIS A 1 188 ? -28.53834 -2.23610  -20.43361 1.000 19.26834 ? 1647 HIS A HB2  1 
ATOM   3048 H  HB3  . HIS A 1 188 ? -29.94308 -2.19942  -19.69147 1.000 19.26834 ? 1647 HIS A HB3  1 
ATOM   3049 H  HD1  . HIS A 1 188 ? -28.02186 -0.26899  -18.67756 1.000 21.41593 ? 1647 HIS A HD1  1 
ATOM   3050 H  HD2  . HIS A 1 188 ? -28.14036 -3.90222  -17.27185 1.000 20.59792 ? 1647 HIS A HD2  1 
ATOM   3051 H  HE1  . HIS A 1 188 ? -27.02477 -0.17766  -16.53766 1.000 21.72542 ? 1647 HIS A HE1  1 
ATOM   3052 N  N    . ASP A 1 189 ? -29.56299 -4.39205  -22.29374 1.000 16.98872 ? 1648 ASP A N    1 
ATOM   3053 C  CA   . ASP A 1 189 ? -30.39242 -4.54280  -23.48900 1.000 18.67307 ? 1648 ASP A CA   1 
ATOM   3054 C  C    . ASP A 1 189 ? -31.17142 -5.84818  -23.48955 1.000 17.23872 ? 1648 ASP A C    1 
ATOM   3055 O  O    . ASP A 1 189 ? -32.15434 -5.95827  -24.23213 1.000 19.20461 ? 1648 ASP A O    1 
ATOM   3056 C  CB   . ASP A 1 189 ? -29.54154 -4.47734  -24.75132 1.000 21.87345 ? 1648 ASP A CB   1 
ATOM   3057 C  CG   . ASP A 1 189 ? -28.87381 -3.11559  -24.96233 1.000 26.38190 ? 1648 ASP A CG   1 
ATOM   3058 O  OD1  . ASP A 1 189 ? -29.14519 -2.13118  -24.22993 1.000 29.31899 ? 1648 ASP A OD1  1 
ATOM   3059 O  OD2  . ASP A 1 189 ? -28.04317 -3.02894  -25.88117 1.000 30.22689 ? 1648 ASP A OD2  1 
ATOM   3060 H  H    . ASP A 1 189 ? -28.71834 -4.35045  -22.45006 1.000 20.38647 ? 1648 ASP A H    1 
ATOM   3061 H  HA   . ASP A 1 189 ? -31.01990 -3.80332  -23.50712 1.000 22.40769 ? 1648 ASP A HA   1 
ATOM   3062 H  HB2  . ASP A 1 189 ? -28.84143 -5.14618  -24.69303 1.000 26.24814 ? 1648 ASP A HB2  1 
ATOM   3063 H  HB3  . ASP A 1 189 ? -30.10613 -4.65417  -25.52000 1.000 26.24814 ? 1648 ASP A HB3  1 
ATOM   3064 N  N    . ASP A 1 190 ? -30.76453 -6.81664  -22.67394 1.000 15.94642 ? 1649 ASP A N    1 
ATOM   3065 C  CA   . ASP A 1 190 ? -31.43303 -8.11158  -22.60845 1.000 15.06212 ? 1649 ASP A CA   1 
ATOM   3066 C  C    . ASP A 1 190 ? -32.48133 -8.19702  -21.52227 1.000 13.82520 ? 1649 ASP A C    1 
ATOM   3067 O  O    . ASP A 1 190 ? -33.20577 -9.18696  -21.48888 1.000 14.94361 ? 1649 ASP A O    1 
ATOM   3068 C  CB   . ASP A 1 190 ? -30.38295 -9.19671  -22.42544 1.000 15.18062 ? 1649 ASP A CB   1 
ATOM   3069 C  CG   . ASP A 1 190 ? -29.40137 -9.17380  -23.56142 1.000 17.05968 ? 1649 ASP A CG   1 
ATOM   3070 O  OD1  . ASP A 1 190 ? -29.84758 -9.49057  -24.69968 1.000 21.31258 ? 1649 ASP A OD1  1 
ATOM   3071 O  OD2  . ASP A 1 190 ? -28.22630 -8.80038  -23.37008 1.000 15.56752 ? 1649 ASP A OD2  1 
ATOM   3072 H  H    . ASP A 1 190 ? -30.09346 -6.74670  -22.14068 1.000 19.13571 ? 1649 ASP A H    1 
ATOM   3073 H  HA   . ASP A 1 190 ? -31.89810 -8.27955  -23.44295 1.000 18.07454 ? 1649 ASP A HA   1 
ATOM   3074 H  HB2  . ASP A 1 190 ? -29.90135 -9.04638  -21.59697 1.000 18.21674 ? 1649 ASP A HB2  1 
ATOM   3075 H  HB3  . ASP A 1 190 ? -30.81365 -10.06563 -22.40583 1.000 18.21674 ? 1649 ASP A HB3  1 
ATOM   3076 N  N    . LEU A 1 191 ? -32.61860 -7.17123  -20.66889 1.000 13.90939 ? 1650 LEU A N    1 
ATOM   3077 C  CA   . LEU A 1 191 ? -33.56375 -7.24356  -19.54719 1.000 14.63579 ? 1650 LEU A CA   1 
ATOM   3078 C  C    . LEU A 1 191 ? -35.01682 -7.30207  -20.00985 1.000 15.75695 ? 1650 LEU A C    1 
ATOM   3079 O  O    . LEU A 1 191 ? -35.84036 -7.94977  -19.35002 1.000 16.27536 ? 1650 LEU A O    1 
ATOM   3080 C  CB   . LEU A 1 191 ? -33.31018 -6.10313  -18.56181 1.000 16.02278 ? 1650 LEU A CB   1 
ATOM   3081 C  CG   . LEU A 1 191 ? -32.02678 -6.25594  -17.72766 1.000 18.00455 ? 1650 LEU A CG   1 
ATOM   3082 C  CD1  . LEU A 1 191 ? -31.73658 -4.95279  -17.00557 1.000 19.22568 ? 1650 LEU A CD1  1 
ATOM   3083 C  CD2  . LEU A 1 191 ? -32.09412 -7.40833  -16.75914 1.000 18.71247 ? 1650 LEU A CD2  1 
ATOM   3084 H  H    . LEU A 1 191 ? -32.18189 -6.43192  -20.71686 1.000 16.69127 ? 1650 LEU A H    1 
ATOM   3085 H  HA   . LEU A 1 191 ? -33.40622 -8.06790  -19.06084 1.000 17.56295 ? 1650 LEU A HA   1 
ATOM   3086 H  HB2  . LEU A 1 191 ? -33.23936 -5.27434  -19.06080 1.000 19.22734 ? 1650 LEU A HB2  1 
ATOM   3087 H  HB3  . LEU A 1 191 ? -34.05753 -6.05633  -17.94523 1.000 19.22734 ? 1650 LEU A HB3  1 
ATOM   3088 H  HG   . LEU A 1 191 ? -31.29342 -6.46040  -18.32873 1.000 21.60547 ? 1650 LEU A HG   1 
ATOM   3089 H  HD11 . LEU A 1 191 ? -30.93074 -5.05788  -16.47597 1.000 23.07082 ? 1650 LEU A HD11 1 
ATOM   3090 H  HD12 . LEU A 1 191 ? -31.61185 -4.24923  -17.66159 1.000 23.07082 ? 1650 LEU A HD12 1 
ATOM   3091 H  HD13 . LEU A 1 191 ? -32.48600 -4.73786  -16.42845 1.000 23.07082 ? 1650 LEU A HD13 1 
ATOM   3092 H  HD21 . LEU A 1 191 ? -31.32247 -7.37326  -16.17244 1.000 22.45497 ? 1650 LEU A HD21 1 
ATOM   3093 H  HD22 . LEU A 1 191 ? -32.90922 -7.33590  -16.23831 1.000 22.45497 ? 1650 LEU A HD22 1 
ATOM   3094 H  HD23 . LEU A 1 191 ? -32.09302 -8.24037  -17.25774 1.000 22.45497 ? 1650 LEU A HD23 1 
ATOM   3095 N  N    . GLU A 1 192 ? -35.35655 -6.61830  -21.10847 1.000 17.43082 ? 1651 GLU A N    1 
ATOM   3096 C  CA   . GLU A 1 192 ? -36.74053 -6.70230  -21.57494 1.000 19.15472 ? 1651 GLU A CA   1 
ATOM   3097 C  C    . GLU A 1 192 ? -37.12209 -8.12591  -21.94694 1.000 18.03354 ? 1651 GLU A C    1 
ATOM   3098 O  O    . GLU A 1 192 ? -38.20902 -8.61529  -21.56797 1.000 18.43877 ? 1651 GLU A O    1 
ATOM   3099 C  CB   . GLU A 1 192 ? -36.95126 -5.74867  -22.75164 1.000 22.48673 ? 1651 GLU A CB   1 
ATOM   3100 C  CG   . GLU A 1 192 ? -38.37881 -5.78460  -23.25528 1.000 27.57679 ? 1651 GLU A CG   1 
ATOM   3101 C  CD   . GLU A 1 192 ? -38.68233 -4.66339  -24.23298 1.000 33.52742 ? 1651 GLU A CD   1 
ATOM   3102 O  OE1  . GLU A 1 192 ? -37.72288 -4.04137  -24.76112 1.000 36.33293 ? 1651 GLU A OE1  1 
ATOM   3103 O  OE2  . GLU A 1 192 ? -39.87339 -4.40472  -24.47444 1.000 35.67761 ? 1651 GLU A OE2  1 
ATOM   3104 H  H    . GLU A 1 192 ? -34.83087 -6.12439  -21.57679 1.000 20.91698 ? 1651 GLU A H    1 
ATOM   3105 H  HA   . GLU A 1 192 ? -37.33057 -6.42489  -20.85675 1.000 22.98566 ? 1651 GLU A HA   1 
ATOM   3106 H  HB2  . GLU A 1 192 ? -36.75097 -4.84280  -22.46846 1.000 26.98408 ? 1651 GLU A HB2  1 
ATOM   3107 H  HB3  . GLU A 1 192 ? -36.36476 -6.00585  -23.48019 1.000 26.98408 ? 1651 GLU A HB3  1 
ATOM   3108 H  HG2  . GLU A 1 192 ? -38.53347 -6.62825  -23.70830 1.000 33.09215 ? 1651 GLU A HG2  1 
ATOM   3109 H  HG3  . GLU A 1 192 ? -38.98275 -5.69733  -22.50126 1.000 33.09215 ? 1651 GLU A HG3  1 
ATOM   3110 N  N    . ARG A 1 193 ? -36.23428 -8.81900  -22.66420 1.000 17.30447 ? 1652 ARG A N    1 
ATOM   3111 C  CA   . ARG A 1 193 ? -36.53229 -10.20239 -23.05733 1.000 17.50708 ? 1652 ARG A CA   1 
ATOM   3112 C  C    . ARG A 1 193 ? -36.54497 -11.11949 -21.84271 1.000 15.87542 ? 1652 ARG A C    1 
ATOM   3113 O  O    . ARG A 1 193 ? -37.44996 -11.97005 -21.69474 1.000 16.85703 ? 1652 ARG A O    1 
ATOM   3114 C  CB   . ARG A 1 193 ? -35.47067 -10.69273 -24.05070 1.000 19.03621 ? 1652 ARG A CB   1 
ATOM   3115 C  CG   . ARG A 1 193 ? -35.49686 -12.19739 -24.26329 1.000 19.39418 ? 1652 ARG A CG   1 
ATOM   3116 C  CD   . ARG A 1 193 ? -34.47445 -12.63039 -25.30891 1.000 19.41259 ? 1652 ARG A CD   1 
ATOM   3117 N  NE   . ARG A 1 193 ? -33.10640 -12.41906 -24.84994 1.000 19.24419 ? 1652 ARG A NE   1 
ATOM   3118 C  CZ   . ARG A 1 193 ? -32.43395 -13.23221 -24.04225 1.000 19.77844 ? 1652 ARG A CZ   1 
ATOM   3119 N  NH1  . ARG A 1 193 ? -32.97026 -14.34968 -23.58435 1.000 21.18385 ? 1652 ARG A NH1  1 
ATOM   3120 N  NH2  . ARG A 1 193 ? -31.18234 -12.91276 -23.67484 1.000 19.20471 ? 1652 ARG A NH2  1 
ATOM   3121 H  H    . ARG A 1 193 ? -35.47223 -8.52199  -22.93001 1.000 20.76536 ? 1652 ARG A H    1 
ATOM   3122 H  HA   . ARG A 1 193 ? -37.40433 -10.22689 -23.48141 1.000 21.00850 ? 1652 ARG A HA   1 
ATOM   3123 H  HB2  . ARG A 1 193 ? -35.62401 -10.26757 -24.90896 1.000 22.84345 ? 1652 ARG A HB2  1 
ATOM   3124 H  HB3  . ARG A 1 193 ? -34.59259 -10.45429 -23.71451 1.000 22.84345 ? 1652 ARG A HB3  1 
ATOM   3125 H  HG2  . ARG A 1 193 ? -35.28699 -12.64385 -23.42811 1.000 23.27302 ? 1652 ARG A HG2  1 
ATOM   3126 H  HG3  . ARG A 1 193 ? -36.37793 -12.46359 -24.56949 1.000 23.27302 ? 1652 ARG A HG3  1 
ATOM   3127 H  HD2  . ARG A 1 193 ? -34.58929 -13.57513 -25.49646 1.000 23.29511 ? 1652 ARG A HD2  1 
ATOM   3128 H  HD3  . ARG A 1 193 ? -34.60640 -12.11296 -26.11869 1.000 23.29511 ? 1652 ARG A HD3  1 
ATOM   3129 H  HE   . ARG A 1 193 ? -32.70231 -11.71115 -25.12412 1.000 23.09303 ? 1652 ARG A HE   1 
ATOM   3130 H  HH11 . ARG A 1 193 ? -33.77226 -14.56493 -23.80812 1.000 25.42062 ? 1652 ARG A HH11 1 
ATOM   3131 H  HH12 . ARG A 1 193 ? -32.51731 -14.86173 -23.06257 1.000 25.42062 ? 1652 ARG A HH12 1 
ATOM   3132 H  HH21 . ARG A 1 193 ? -30.82197 -12.18665 -23.96205 1.000 23.04565 ? 1652 ARG A HH21 1 
ATOM   3133 H  HH22 . ARG A 1 193 ? -30.74122 -13.43431 -23.15235 1.000 23.04565 ? 1652 ARG A HH22 1 
ATOM   3134 N  N    . LEU A 1 194 ? -35.54116 -10.97195 -20.96214 1.000 15.65169 ? 1653 LEU A N    1 
ATOM   3135 C  CA   . LEU A 1 194 ? -35.45104 -11.86547 -19.82574 1.000 16.25169 ? 1653 LEU A CA   1 
ATOM   3136 C  C    . LEU A 1 194 ? -36.59480 -11.65757 -18.83625 1.000 16.34908 ? 1653 LEU A C    1 
ATOM   3137 O  O    . LEU A 1 194 ? -37.02381 -12.62292 -18.19465 1.000 17.36497 ? 1653 LEU A O    1 
ATOM   3138 C  CB   . LEU A 1 194 ? -34.11411 -11.63903 -19.14353 1.000 15.56485 ? 1653 LEU A CB   1 
ATOM   3139 C  CG   . LEU A 1 194 ? -32.85570 -12.14573 -19.88184 1.000 16.23592 ? 1653 LEU A CG   1 
ATOM   3140 C  CD1  . LEU A 1 194 ? -31.62448 -11.66363 -19.20894 1.000 16.68329 ? 1653 LEU A CD1  1 
ATOM   3141 C  CD2  . LEU A 1 194 ? -32.87297 -13.67840 -19.94021 1.000 16.11749 ? 1653 LEU A CD2  1 
ATOM   3142 H  H    . LEU A 1 194 ? -34.92284 -10.37604 -21.00864 1.000 18.78202 ? 1653 LEU A H    1 
ATOM   3143 H  HA   . LEU A 1 194 ? -35.50452 -12.78456 -20.13121 1.000 19.50203 ? 1653 LEU A HA   1 
ATOM   3144 H  HB2  . LEU A 1 194 ? -34.00201 -10.68400 -19.01607 1.000 18.67782 ? 1653 LEU A HB2  1 
ATOM   3145 H  HB3  . LEU A 1 194 ? -34.13779 -12.08793 -18.28398 1.000 18.67782 ? 1653 LEU A HB3  1 
ATOM   3146 H  HG   . LEU A 1 194 ? -32.85120 -11.79988 -20.78807 1.000 19.48310 ? 1653 LEU A HG   1 
ATOM   3147 H  HD11 . LEU A 1 194 ? -30.85070 -11.99732 -19.68939 1.000 20.01995 ? 1653 LEU A HD11 1 
ATOM   3148 H  HD12 . LEU A 1 194 ? -31.62238 -10.69363 -19.21145 1.000 20.01995 ? 1653 LEU A HD12 1 
ATOM   3149 H  HD13 . LEU A 1 194 ? -31.61411 -11.99207 -18.29630 1.000 20.01995 ? 1653 LEU A HD13 1 
ATOM   3150 H  HD21 . LEU A 1 194 ? -32.02540 -13.99053 -20.29391 1.000 19.34099 ? 1653 LEU A HD21 1 
ATOM   3151 H  HD22 . LEU A 1 194 ? -33.00630 -14.02705 -19.04491 1.000 19.34099 ? 1653 LEU A HD22 1 
ATOM   3152 H  HD23 . LEU A 1 194 ? -33.59787 -13.96428 -20.51787 1.000 19.34099 ? 1653 LEU A HD23 1 
ATOM   3153 N  N    . GLY A 1 195 ? -37.04182 -10.43135 -18.68641 1.000 16.02798 ? 1654 GLY A N    1 
ATOM   3154 C  CA   . GLY A 1 195 ? -37.93191 -10.06284 -17.59645 1.000 16.13851 ? 1654 GLY A CA   1 
ATOM   3155 C  C    . GLY A 1 195 ? -37.21204 -9.92194  -16.26183 1.000 15.42009 ? 1654 GLY A C    1 
ATOM   3156 O  O    . GLY A 1 195 ? -36.02172 -10.24472 -16.11998 1.000 16.09113 ? 1654 GLY A O    1 
ATOM   3157 H  H    . GLY A 1 195 ? -36.84397 -9.77798  -19.20943 1.000 19.23357 ? 1654 GLY A H    1 
ATOM   3158 H  HA2  . GLY A 1 195 ? -38.35511 -9.21493  -17.80341 1.000 19.36621 ? 1654 GLY A HA2  1 
ATOM   3159 H  HA3  . GLY A 1 195 ? -38.61709 -10.74275 -17.50081 1.000 19.36621 ? 1654 GLY A HA3  1 
ATOM   3160 N  N    . PRO A 1 196 ? -37.91294 -9.35819  -15.26849 1.000 15.27800 ? 1655 PRO A N    1 
ATOM   3161 C  CA   . PRO A 1 196 ? -37.24032 -8.95291  -14.03832 1.000 16.13596 ? 1655 PRO A CA   1 
ATOM   3162 C  C    . PRO A 1 196 ? -36.87252 -10.10368 -13.12410 1.000 15.62275 ? 1655 PRO A C    1 
ATOM   3163 O  O    . PRO A 1 196 ? -36.01485 -9.92183  -12.25145 1.000 19.12561 ? 1655 PRO A O    1 
ATOM   3164 C  CB   . PRO A 1 196 ? -38.26290 -8.03294  -13.37782 1.000 17.94663 ? 1655 PRO A CB   1 
ATOM   3165 C  CG   . PRO A 1 196 ? -39.57933 -8.50408  -13.91177 1.000 18.38342 ? 1655 PRO A CG   1 
ATOM   3166 C  CD   . PRO A 1 196 ? -39.30961 -8.88590  -15.32705 1.000 16.45698 ? 1655 PRO A CD   1 
ATOM   3167 H  HA   . PRO A 1 196 ? -36.43699 -8.45299  -14.25192 1.000 19.36315 ? 1655 PRO A HA   1 
ATOM   3168 H  HB2  . PRO A 1 196 ? -38.22233 -8.12738  -12.41328 1.000 21.53596 ? 1655 PRO A HB2  1 
ATOM   3169 H  HB3  . PRO A 1 196 ? -38.09311 -7.11136  -13.62836 1.000 21.53596 ? 1655 PRO A HB3  1 
ATOM   3170 H  HG2  . PRO A 1 196 ? -39.88911 -9.26767  -13.40004 1.000 22.06010 ? 1655 PRO A HG2  1 
ATOM   3171 H  HG3  . PRO A 1 196 ? -40.23065 -7.78682  -13.86464 1.000 22.06010 ? 1655 PRO A HG3  1 
ATOM   3172 H  HD2  . PRO A 1 196 ? -39.90527 -9.59472  -15.61629 1.000 19.74837 ? 1655 PRO A HD2  1 
ATOM   3173 H  HD3  . PRO A 1 196 ? -39.39410 -8.12030  -15.91664 1.000 19.74837 ? 1655 PRO A HD3  1 
ATOM   3174 N  N    . GLY A 1 197 ? -37.48890 -11.26931 -13.26864 1.000 14.13576 ? 1656 GLY A N    1 
ATOM   3175 C  CA   . GLY A 1 197 ? -37.16224 -12.38683 -12.42065 1.000 15.35409 ? 1656 GLY A CA   1 
ATOM   3176 C  C    . GLY A 1 197 ? -35.99034 -13.16328 -12.97536 1.000 13.72775 ? 1656 GLY A C    1 
ATOM   3177 O  O    . GLY A 1 197 ? -34.95801 -13.30400 -12.28709 1.000 13.64882 ? 1656 GLY A O    1 
ATOM   3178 H  H    . GLY A 1 197 ? -38.09904 -11.43111 -13.85272 1.000 16.96292 ? 1656 GLY A H    1 
ATOM   3179 H  HA2  . GLY A 1 197 ? -36.93293 -12.06743 -11.53391 1.000 18.42491 ? 1656 GLY A HA2  1 
ATOM   3180 H  HA3  . GLY A 1 197 ? -37.92643 -12.98059 -12.35461 1.000 18.42491 ? 1656 GLY A HA3  1 
ATOM   3181 N  N    . LYS A 1 198 ? -36.10987 -13.62280 -14.21890 1.000 13.99880 ? 1657 LYS A N    1 
ATOM   3182 C  CA   . LYS A 1 198 ? -35.00587 -14.29908 -14.86773 1.000 13.86198 ? 1657 LYS A CA   1 
ATOM   3183 C  C    . LYS A 1 198 ? -33.76748 -13.41143 -14.86563 1.000 13.54356 ? 1657 LYS A C    1 
ATOM   3184 O  O    . LYS A 1 198 ? -32.66476 -13.91856 -14.68782 1.000 15.13837 ? 1657 LYS A O    1 
ATOM   3185 C  CB   . LYS A 1 198 ? -35.31690 -14.64181 -16.30476 1.000 15.31220 ? 1657 LYS A CB   1 
ATOM   3186 C  CG   . LYS A 1 198 ? -36.20152 -15.80103 -16.52639 1.000 19.03087 ? 1657 LYS A CG   1 
ATOM   3187 C  CD   . LYS A 1 198 ? -36.22308 -15.98142 -18.06735 1.000 20.63634 ? 1657 LYS A CD   1 
ATOM   3188 C  CE   . LYS A 1 198 ? -36.92056 -17.13928 -18.53871 1.000 20.44683 ? 1657 LYS A CE   1 
ATOM   3189 N  NZ   . LYS A 1 198 ? -37.14082 -17.05699 -19.96644 1.000 16.47292 ? 1657 LYS A NZ   1 
ATOM   3190 H  H    . LYS A 1 198 ? -36.81796 -13.55372 -14.70205 1.000 16.79856 ? 1657 LYS A H    1 
ATOM   3191 H  HA   . LYS A 1 198 ? -34.85152 -15.12388 -14.38113 1.000 16.63438 ? 1657 LYS A HA   1 
ATOM   3192 H  HB2  . LYS A 1 198 ? -35.74717 -13.87349 -16.71152 1.000 18.37464 ? 1657 LYS A HB2  1 
ATOM   3193 H  HB3  . LYS A 1 198 ? -34.48016 -14.83162 -16.75725 1.000 18.37464 ? 1657 LYS A HB3  1 
ATOM   3194 H  HG2  . LYS A 1 198 ? -35.84481 -16.59693 -16.10189 1.000 22.83705 ? 1657 LYS A HG2  1 
ATOM   3195 H  HG3  . LYS A 1 198 ? -37.09685 -15.62304 -16.19838 1.000 22.83705 ? 1657 LYS A HG3  1 
ATOM   3196 H  HD2  . LYS A 1 198 ? -36.65260 -15.20581 -18.46084 1.000 24.76361 ? 1657 LYS A HD2  1 
ATOM   3197 H  HD3  . LYS A 1 198 ? -35.30764 -16.04850 -18.38101 1.000 24.76361 ? 1657 LYS A HD3  1 
ATOM   3198 H  HE2  . LYS A 1 198 ? -36.39444 -17.93275 -18.35294 1.000 24.53620 ? 1657 LYS A HE2  1 
ATOM   3199 H  HE3  . LYS A 1 198 ? -37.78180 -17.20130 -18.09676 1.000 24.53620 ? 1657 LYS A HE3  1 
ATOM   3200 H  HZ1  . LYS A 1 198 ? -37.62814 -16.33739 -20.15828 1.000 19.76751 ? 1657 LYS A HZ1  1 
ATOM   3201 H  HZ2  . LYS A 1 198 ? -37.57212 -17.78195 -20.25018 1.000 19.76751 ? 1657 LYS A HZ2  1 
ATOM   3202 H  HZ3  . LYS A 1 198 ? -36.36121 -16.99969 -20.39190 1.000 19.76751 ? 1657 LYS A HZ3  1 
ATOM   3203 N  N    . GLY A 1 199 ? -33.92218 -12.07945 -15.03707 1.000 13.19346 ? 1658 GLY A N    1 
ATOM   3204 C  CA   . GLY A 1 199 ? -32.77345 -11.21767 -15.16536 1.000 14.20930 ? 1658 GLY A CA   1 
ATOM   3205 C  C    . GLY A 1 199 ? -32.04896 -10.96078 -13.85892 1.000 14.20151 ? 1658 GLY A C    1 
ATOM   3206 O  O    . GLY A 1 199 ? -30.98760 -10.32343 -13.88641 1.000 15.37788 ? 1658 GLY A O    1 
ATOM   3207 H  H    . GLY A 1 199 ? -34.67991 -11.67489 -15.07926 1.000 15.83215 ? 1658 GLY A H    1 
ATOM   3208 H  HA2  . GLY A 1 199 ? -32.14407 -11.62244 -15.78256 1.000 17.05117 ? 1658 GLY A HA2  1 
ATOM   3209 H  HA3  . GLY A 1 199 ? -33.06020 -10.36251 -15.52226 1.000 17.05117 ? 1658 GLY A HA3  1 
ATOM   3210 N  N    . GLU A 1 200 ? -32.56550 -11.40092 -12.72026 1.000 13.96722 ? 1659 GLU A N    1 
ATOM   3211 C  CA   . GLU A 1 200 ? -31.90951 -11.18848 -11.43348 1.000 13.09875 ? 1659 GLU A CA   1 
ATOM   3212 C  C    . GLU A 1 200 ? -30.59831 -11.98239 -11.37083 1.000 12.04593 ? 1659 GLU A C    1 
ATOM   3213 O  O    . GLU A 1 200 ? -30.59548 -13.22845 -11.47093 1.000 11.64590 ? 1659 GLU A O    1 
ATOM   3214 C  CB   . GLU A 1 200 ? -32.79934 -11.57942 -10.25668 1.000 15.75431 ? 1659 GLU A CB   1 
ATOM   3215 C  CG   . GLU A 1 200 ? -33.89026 -10.60341 -9.92494  1.000 18.54149 ? 1659 GLU A CG   1 
ATOM   3216 C  CD   . GLU A 1 200 ? -33.35964 -9.38301  -9.11784  1.000 23.02359 ? 1659 GLU A CD   1 
ATOM   3217 O  OE1  . GLU A 1 200 ? -32.48154 -9.54669  -8.26691  1.000 23.64998 ? 1659 GLU A OE1  1 
ATOM   3218 O  OE2  . GLU A 1 200 ? -33.87628 -8.28660  -9.35217  1.000 27.28439 ? 1659 GLU A OE2  1 
ATOM   3219 H  H    . GLU A 1 200 ? -33.30688 -11.83282 -12.66182 1.000 16.76066 ? 1659 GLU A H    1 
ATOM   3220 H  HA   . GLU A 1 200 ? -31.72304 -10.23955 -11.35822 1.000 15.71850 ? 1659 GLU A HA   1 
ATOM   3221 H  HB2  . GLU A 1 200 ? -33.22249 -12.42777 -10.46195 1.000 18.90517 ? 1659 GLU A HB2  1 
ATOM   3222 H  HB3  . GLU A 1 200 ? -32.24154 -11.66910 -9.46818  1.000 18.90517 ? 1659 GLU A HB3  1 
ATOM   3223 H  HG2  . GLU A 1 200 ? -34.28390 -10.27386 -10.74795 1.000 22.24979 ? 1659 GLU A HG2  1 
ATOM   3224 H  HG3  . GLU A 1 200 ? -34.56509 -11.04975 -9.38988  1.000 22.24979 ? 1659 GLU A HG3  1 
ATOM   3225 N  N    . VAL A 1 201 ? -29.50639 -11.27229 -11.10629 1.000 11.54326 ? 1660 VAL A N    1 
ATOM   3226 C  CA   . VAL A 1 201 ? -28.17980 -11.88456 -10.95477 1.000 10.61159 ? 1660 VAL A CA   1 
ATOM   3227 C  C    . VAL A 1 201 ? -27.35177 -10.88710 -10.16054 1.000 11.04575 ? 1660 VAL A C    1 
ATOM   3228 O  O    . VAL A 1 201 ? -27.62681 -9.67478  -10.17397 1.000 11.09584 ? 1660 VAL A O    1 
ATOM   3229 C  CB   . VAL A 1 201 ? -27.55813 -12.22800 -12.33205 1.000 11.38012 ? 1660 VAL A CB   1 
ATOM   3230 C  CG1  . VAL A 1 201 ? -27.39414 -11.01576 -13.22837 1.000 13.07759 ? 1660 VAL A CG1  1 
ATOM   3231 C  CG2  . VAL A 1 201 ? -26.22766 -12.98282 -12.16981 1.000 12.41700 ? 1660 VAL A CG2  1 
ATOM   3232 H  H    . VAL A 1 201 ? -29.50223 -10.41802 -11.00720 1.000 13.85191 ? 1660 VAL A H    1 
ATOM   3233 H  HA   . VAL A 1 201 ? -28.23503 -12.71612 -10.45841 1.000 12.73391 ? 1660 VAL A HA   1 
ATOM   3234 H  HB   . VAL A 1 201 ? -28.18554 -12.81424 -12.78324 1.000 13.65615 ? 1660 VAL A HB   1 
ATOM   3235 H  HG11 . VAL A 1 201 ? -27.04715 -11.30286 -14.08748 1.000 15.69311 ? 1660 VAL A HG11 1 
ATOM   3236 H  HG12 . VAL A 1 201 ? -28.25810 -10.59071 -13.34588 1.000 15.69311 ? 1660 VAL A HG12 1 
ATOM   3237 H  HG13 . VAL A 1 201 ? -26.77472 -10.39640 -12.81169 1.000 15.69311 ? 1660 VAL A HG13 1 
ATOM   3238 H  HG21 . VAL A 1 201 ? -25.90192 -13.24065 -13.04634 1.000 14.90040 ? 1660 VAL A HG21 1 
ATOM   3239 H  HG22 . VAL A 1 201 ? -25.58477 -12.40003 -11.73627 1.000 14.90040 ? 1660 VAL A HG22 1 
ATOM   3240 H  HG23 . VAL A 1 201 ? -26.37686 -13.77267 -11.62687 1.000 14.90040 ? 1660 VAL A HG23 1 
ATOM   3241 N  N    . ARG A 1 202 ? -26.36330 -11.39256 -9.42520  1.000 10.78793 ? 1661 ARG A N    1 
ATOM   3242 C  CA   . ARG A 1 202 ? -25.41285 -10.54064 -8.73928  1.000 11.09069 ? 1661 ARG A CA   1 
ATOM   3243 C  C    . ARG A 1 202 ? -24.00668 -10.94604 -9.15522  1.000 12.15121 ? 1661 ARG A C    1 
ATOM   3244 O  O    . ARG A 1 202 ? -23.65039 -12.13591 -9.07551  1.000 14.21720 ? 1661 ARG A O    1 
ATOM   3245 C  CB   . ARG A 1 202 ? -25.53355 -10.63553 -7.21265  1.000 13.53293 ? 1661 ARG A CB   1 
ATOM   3246 C  CG   . ARG A 1 202 ? -26.89555 -10.28257 -6.65992  1.000 14.79362 ? 1661 ARG A CG   1 
ATOM   3247 C  CD   . ARG A 1 202 ? -27.12576 -8.80130  -6.78969  1.000 15.94646 ? 1661 ARG A CD   1 
ATOM   3248 N  NE   . ARG A 1 202 ? -28.43548 -8.46074  -6.23840  1.000 18.22555 ? 1661 ARG A NE   1 
ATOM   3249 C  CZ   . ARG A 1 202 ? -29.59139 -8.68989  -6.84993  1.000 19.69952 ? 1661 ARG A CZ   1 
ATOM   3250 N  NH1  . ARG A 1 202 ? -29.63676 -9.13120  -8.08761  1.000 19.62319 ? 1661 ARG A NH1  1 
ATOM   3251 N  NH2  . ARG A 1 202 ? -30.72126 -8.48503  -6.17893  1.000 22.32597 ? 1661 ARG A NH2  1 
ATOM   3252 H  H    . ARG A 1 202 ? -26.22660 -12.23395 -9.31130  1.000 12.94551 ? 1661 ARG A H    1 
ATOM   3253 H  HA   . ARG A 1 202 ? -25.58858 -9.62300  -8.99995  1.000 13.30882 ? 1661 ARG A HA   1 
ATOM   3254 H  HB2  . ARG A 1 202 ? -25.33751 -11.54694 -6.94471  1.000 16.23952 ? 1661 ARG A HB2  1 
ATOM   3255 H  HB3  . ARG A 1 202 ? -24.89104 -10.02732 -6.81495  1.000 16.23952 ? 1661 ARG A HB3  1 
ATOM   3256 H  HG2  . ARG A 1 202 ? -27.58355 -10.75072 -7.15830  1.000 17.75234 ? 1661 ARG A HG2  1 
ATOM   3257 H  HG3  . ARG A 1 202 ? -26.94218 -10.52520 -5.72192  1.000 17.75234 ? 1661 ARG A HG3  1 
ATOM   3258 H  HD2  . ARG A 1 202 ? -26.44344 -8.31832  -6.29768  1.000 19.13575 ? 1661 ARG A HD2  1 
ATOM   3259 H  HD3  . ARG A 1 202 ? -27.10352 -8.54598  -7.72522  1.000 19.13575 ? 1661 ARG A HD3  1 
ATOM   3260 H  HE   . ARG A 1 202 ? -28.45916 -8.08612  -5.46464  1.000 21.87066 ? 1661 ARG A HE   1 
ATOM   3261 H  HH11 . ARG A 1 202 ? -28.90729 -9.27768  -8.51892  1.000 23.54783 ? 1661 ARG A HH11 1 
ATOM   3262 H  HH12 . ARG A 1 202 ? -30.39591 -9.27338  -8.46588  1.000 23.54783 ? 1661 ARG A HH12 1 
ATOM   3263 H  HH21 . ARG A 1 202 ? -30.69392 -8.20931  -5.36478  1.000 26.79117 ? 1661 ARG A HH21 1 
ATOM   3264 H  HH22 . ARG A 1 202 ? -31.47921 -8.62829  -6.55918  1.000 26.79117 ? 1661 ARG A HH22 1 
ATOM   3265 N  N    . PRO A 1 203 ? -23.17904 -10.01485 -9.58294  1.000 11.01177 ? 1662 PRO A N    1 
ATOM   3266 C  CA   . PRO A 1 203 ? -23.48867 -8.63705  -9.94596  1.000 11.60641 ? 1662 PRO A CA   1 
ATOM   3267 C  C    . PRO A 1 203 ? -24.54179 -8.59274  -11.01429 1.000 10.66689 ? 1662 PRO A C    1 
ATOM   3268 O  O    . PRO A 1 203 ? -24.60497 -9.47706  -11.86218 1.000 10.85893 ? 1662 PRO A O    1 
ATOM   3269 C  CB   . PRO A 1 203 ? -22.12299 -8.12288  -10.48106 1.000 12.10646 ? 1662 PRO A CB   1 
ATOM   3270 C  CG   . PRO A 1 203 ? -21.10280 -9.01625  -9.90990  1.000 12.92230 ? 1662 PRO A CG   1 
ATOM   3271 C  CD   . PRO A 1 203 ? -21.75172 -10.35709 -9.85052  1.000 12.64852 ? 1662 PRO A CD   1 
ATOM   3272 H  HA   . PRO A 1 203 ? -23.75959 -8.11690  -9.17333  1.000 13.92769 ? 1662 PRO A HA   1 
ATOM   3273 H  HB2  . PRO A 1 203 ? -22.11494 -8.16686  -11.45003 1.000 14.52776 ? 1662 PRO A HB2  1 
ATOM   3274 H  HB3  . PRO A 1 203 ? -21.98170 -7.20866  -10.18927 1.000 14.52776 ? 1662 PRO A HB3  1 
ATOM   3275 H  HG2  . PRO A 1 203 ? -20.32115 -9.03454  -10.48400 1.000 15.50676 ? 1662 PRO A HG2  1 
ATOM   3276 H  HG3  . PRO A 1 203 ? -20.85588 -8.71104  -9.02290  1.000 15.50676 ? 1662 PRO A HG3  1 
ATOM   3277 H  HD2  . PRO A 1 203 ? -21.65862 -10.82650 -10.69425 1.000 15.17822 ? 1662 PRO A HD2  1 
ATOM   3278 H  HD3  . PRO A 1 203 ? -21.38113 -10.89156 -9.13087  1.000 15.17822 ? 1662 PRO A HD3  1 
ATOM   3279 N  N    . GLU A 1 204 ? -25.35510 -7.53936  -10.98917 1.000 10.63004 ? 1663 GLU A N    1 
ATOM   3280 C  CA   A GLU A 1 204 ? -26.39955 -7.37787  -11.99797 0.750 11.75377 ? 1663 GLU A CA   1 
ATOM   3281 C  CA   B GLU A 1 204 ? -26.39658 -7.34442  -11.99346 0.250 10.81683 ? 1663 GLU A CA   1 
ATOM   3282 C  C    . GLU A 1 204 ? -25.79170 -7.24469  -13.39150 1.000 10.50898 ? 1663 GLU A C    1 
ATOM   3283 O  O    . GLU A 1 204 ? -24.60039 -6.92316  -13.58166 1.000 11.91692 ? 1663 GLU A O    1 
ATOM   3284 C  CB   A GLU A 1 204 ? -27.30563 -6.18768  -11.69103 0.750 13.73833 ? 1663 GLU A CB   1 
ATOM   3285 C  CB   B GLU A 1 204 ? -27.16138 -6.05330  -11.71378 0.250 11.09061 ? 1663 GLU A CB   1 
ATOM   3286 C  CG   A GLU A 1 204 ? -26.65452 -4.83918  -11.82454 0.750 17.33075 ? 1663 GLU A CG   1 
ATOM   3287 C  CG   B GLU A 1 204 ? -26.25361 -4.82524  -11.69404 0.250 12.46704 ? 1663 GLU A CG   1 
ATOM   3288 C  CD   A GLU A 1 204 ? -27.54064 -3.71160  -11.28520 0.750 20.35473 ? 1663 GLU A CD   1 
ATOM   3289 C  CD   B GLU A 1 204 ? -26.97000 -3.54488  -11.28421 0.250 13.64612 ? 1663 GLU A CD   1 
ATOM   3290 O  OE1  A GLU A 1 204 ? -28.44514 -3.97867  -10.44275 0.750 22.22077 ? 1663 GLU A OE1  1 
ATOM   3291 O  OE1  B GLU A 1 204 ? -28.21607 -3.47717  -11.42166 0.250 13.88297 ? 1663 GLU A OE1  1 
ATOM   3292 O  OE2  A GLU A 1 204 ? -27.34514 -2.57385  -11.71474 0.750 19.70742 ? 1663 GLU A OE2  1 
ATOM   3293 O  OE2  B GLU A 1 204 ? -26.26630 -2.63006  -10.81686 0.250 14.29620 ? 1663 GLU A OE2  1 
ATOM   3294 H  H    A GLU A 1 204 ? -25.32386 -6.90956  -10.40438 0.750 12.75605 ? 1663 GLU A H    1 
ATOM   3295 H  H    B GLU A 1 204 ? -25.32453 -6.91745  -10.39597 0.250 12.75605 ? 1663 GLU A H    1 
ATOM   3296 H  HA   A GLU A 1 204 ? -26.96136 -8.16856  -11.98856 0.750 14.10453 ? 1663 GLU A HA   1 
ATOM   3297 H  HA   B GLU A 1 204 ? -27.00494 -8.09929  -11.96220 0.250 12.98020 ? 1663 GLU A HA   1 
ATOM   3298 H  HB2  A GLU A 1 204 ? -28.05762 -6.20894  -12.30337 0.750 16.48599 ? 1663 GLU A HB2  1 
ATOM   3299 H  HB2  B GLU A 1 204 ? -27.82757 -5.92399  -12.40686 0.250 13.30873 ? 1663 GLU A HB2  1 
ATOM   3300 H  HB3  A GLU A 1 204 ? -27.61973 -6.26924  -10.77693 0.750 16.48599 ? 1663 GLU A HB3  1 
ATOM   3301 H  HB3  B GLU A 1 204 ? -27.59276 -6.12262  -10.84775 0.250 13.30873 ? 1663 GLU A HB3  1 
ATOM   3302 H  HG2  A GLU A 1 204 ? -25.82362 -4.83617  -11.32404 0.750 20.79690 ? 1663 GLU A HG2  1 
ATOM   3303 H  HG2  B GLU A 1 204 ? -25.53421 -4.97793  -11.06154 0.250 14.96045 ? 1663 GLU A HG2  1 
ATOM   3304 H  HG3  A GLU A 1 204 ? -26.47788 -4.66262  -12.76183 0.750 20.79690 ? 1663 GLU A HG3  1 
ATOM   3305 H  HG3  B GLU A 1 204 ? -25.89044 -4.69015  -12.58328 0.250 14.96045 ? 1663 GLU A HG3  1 
ATOM   3306 N  N    . LEU A 1 205 ? -26.61583 -7.43948  -14.40246 1.000 10.55372 ? 1664 LEU A N    1 
ATOM   3307 C  CA   . LEU A 1 205 ? -26.20620 -7.16801  -15.76837 1.000 11.80906 ? 1664 LEU A CA   1 
ATOM   3308 C  C    . LEU A 1 205 ? -25.78652 -5.70899  -15.88429 1.000 12.05384 ? 1664 LEU A C    1 
ATOM   3309 O  O    . LEU A 1 205 ? -26.39683 -4.81516  -15.27540 1.000 12.96182 ? 1664 LEU A O    1 
ATOM   3310 C  CB   . LEU A 1 205 ? -27.29701 -7.53499  -16.78334 1.000 12.28807 ? 1664 LEU A CB   1 
ATOM   3311 C  CG   . LEU A 1 205 ? -27.60015 -9.02088  -16.87623 1.000 11.94337 ? 1664 LEU A CG   1 
ATOM   3312 C  CD1  . LEU A 1 205 ? -28.68157 -9.19151  -17.92656 1.000 13.09072 ? 1664 LEU A CD1  1 
ATOM   3313 C  CD2  . LEU A 1 205 ? -26.36369 -9.79210  -17.22990 1.000 12.98286 ? 1664 LEU A CD2  1 
ATOM   3314 H  H    . LEU A 1 205 ? -27.42191 -7.72951  -14.32681 1.000 12.66446 ? 1664 LEU A H    1 
ATOM   3315 H  HA   . LEU A 1 205 ? -25.44885 -7.72825  -15.99954 1.000 14.17087 ? 1664 LEU A HA   1 
ATOM   3316 H  HB2  . LEU A 1 205 ? -28.11745 -7.08359  -16.53033 1.000 14.74568 ? 1664 LEU A HB2  1 
ATOM   3317 H  HB3  . LEU A 1 205 ? -27.01247 -7.23828  -17.66193 1.000 14.74568 ? 1664 LEU A HB3  1 
ATOM   3318 H  HG   . LEU A 1 205 ? -27.90727 -9.37491  -16.02697 1.000 14.33205 ? 1664 LEU A HG   1 
ATOM   3319 H  HD11 . LEU A 1 205 ? -28.89255 -10.13440 -18.01231 1.000 15.70887 ? 1664 LEU A HD11 1 
ATOM   3320 H  HD12 . LEU A 1 205 ? -29.47068 -8.69979  -17.65014 1.000 15.70887 ? 1664 LEU A HD12 1 
ATOM   3321 H  HD13 . LEU A 1 205 ? -28.35677 -8.84691  -18.77311 1.000 15.70887 ? 1664 LEU A HD13 1 
ATOM   3322 H  HD21 . LEU A 1 205 ? -26.61867 -10.68185 -17.52012 1.000 15.57944 ? 1664 LEU A HD21 1 
ATOM   3323 H  HD22 . LEU A 1 205 ? -25.89807 -9.33153  -17.94542 1.000 15.57944 ? 1664 LEU A HD22 1 
ATOM   3324 H  HD23 . LEU A 1 205 ? -25.79314 -9.85017  -16.44759 1.000 15.57944 ? 1664 LEU A HD23 1 
ATOM   3325 N  N    . GLY A 1 206 ? -24.74910 -5.49991  -16.66971 1.000 12.76186 ? 1665 GLY A N    1 
ATOM   3326 C  CA   . GLY A 1 206 ? -24.19972 -4.17343  -16.83692 1.000 13.98820 ? 1665 GLY A CA   1 
ATOM   3327 C  C    . GLY A 1 206 ? -24.71691 -3.48140  -18.08981 1.000 12.87763 ? 1665 GLY A C    1 
ATOM   3328 O  O    . GLY A 1 206 ? -25.41695 -4.05016  -18.92419 1.000 13.66715 ? 1665 GLY A O    1 
ATOM   3329 H  H    . GLY A 1 206 ? -24.34496 -6.11274  -17.11771 1.000 15.31424 ? 1665 GLY A H    1 
ATOM   3330 H  HA2  . GLY A 1 206 ? -24.43536 -3.62983  -16.06889 1.000 16.78584 ? 1665 GLY A HA2  1 
ATOM   3331 H  HA3  . GLY A 1 206 ? -23.23341 -4.23213  -16.89774 1.000 16.78584 ? 1665 GLY A HA3  1 
ATOM   3332 N  N    . SER A 1 207 ? -24.32868 -2.20701  -18.20285 1.000 13.25139 ? 1666 SER A N    1 
ATOM   3333 C  CA   . SER A 1 207 ? -24.62617 -1.46743  -19.42138 1.000 14.25937 ? 1666 SER A CA   1 
ATOM   3334 C  C    . SER A 1 207 ? -23.77913 -1.96484  -20.58777 1.000 13.76459 ? 1666 SER A C    1 
ATOM   3335 O  O    . SER A 1 207 ? -22.79604 -2.70440  -20.40151 1.000 13.43035 ? 1666 SER A O    1 
ATOM   3336 C  CB   . SER A 1 207 ? -24.33926 0.00495   -19.20868 1.000 14.81201 ? 1666 SER A CB   1 
ATOM   3337 O  OG   . SER A 1 207 ? -22.90270 0.19398   -19.05697 1.000 14.71208 ? 1666 SER A OG   1 
ATOM   3338 H  H    . SER A 1 207 ? -23.90302 -1.76376  -17.60123 1.000 15.90167 ? 1666 SER A H    1 
ATOM   3339 H  HA   . SER A 1 207 ? -25.56216 -1.59570  -19.64131 1.000 17.11124 ? 1666 SER A HA   1 
ATOM   3340 H  HB2  . SER A 1 207 ? -24.65166 0.50873   -19.97648 1.000 17.77441 ? 1666 SER A HB2  1 
ATOM   3341 H  HB3  . SER A 1 207 ? -24.79123 0.30908   -18.40610 1.000 17.77441 ? 1666 SER A HB3  1 
ATOM   3342 H  HG   . SER A 1 207 ? -22.73171 1.00647   -18.92959 1.000 17.65449 ? 1666 SER A HG   1 
ATOM   3343 N  N    . ARG A 1 208 ? -24.14091 -1.51913  -21.79390 1.000 14.83840 ? 1667 ARG A N    1 
ATOM   3344 C  CA   . ARG A 1 208 ? -23.30410 -1.78853  -22.96101 1.000 16.32013 ? 1667 ARG A CA   1 
ATOM   3345 C  C    . ARG A 1 208 ? -21.87931 -1.28561  -22.72241 1.000 16.37008 ? 1667 ARG A C    1 
ATOM   3346 O  O    . ARG A 1 208 ? -20.90826 -1.89062  -23.17653 1.000 16.75175 ? 1667 ARG A O    1 
ATOM   3347 C  CB   . ARG A 1 208 ? -23.89389 -1.13229  -24.21766 1.000 18.62028 ? 1667 ARG A CB   1 
ATOM   3348 H  H    . ARG A 1 208 ? -24.85333 -1.06670  -21.95931 1.000 17.80607 ? 1667 ARG A H    1 
ATOM   3349 H  HA   . ARG A 1 208 ? -23.28206 -2.74605  -23.11456 1.000 19.58415 ? 1667 ARG A HA   1 
ATOM   3350 N  N    . GLN A 1 209 ? -21.73503 -0.16503  -22.01683 1.000 15.60169 ? 1668 GLN A N    1 
ATOM   3351 C  CA   . GLN A 1 209 ? -20.41711 0.39335   -21.76620 1.000 15.96494 ? 1668 GLN A CA   1 
ATOM   3352 C  C    . GLN A 1 209 ? -19.62377 -0.48954  -20.79448 1.000 14.03304 ? 1668 GLN A C    1 
ATOM   3353 O  O    . GLN A 1 209 ? -18.38933 -0.59934  -20.90251 1.000 13.63038 ? 1668 GLN A O    1 
ATOM   3354 C  CB   . GLN A 1 209 ? -20.51643 1.83811   -21.23001 1.000 19.70228 ? 1668 GLN A CB   1 
ATOM   3355 C  CG   . GLN A 1 209 ? -21.21031 2.86536   -22.14058 1.000 26.23172 ? 1668 GLN A CG   1 
ATOM   3356 C  CD   . GLN A 1 209 ? -22.66880 2.48044   -22.64602 1.000 29.41897 ? 1668 GLN A CD   1 
ATOM   3357 O  OE1  . GLN A 1 209 ? -23.63454 2.19383   -21.87162 1.000 27.96633 ? 1668 GLN A OE1  1 
ATOM   3358 N  NE2  . GLN A 1 209 ? -22.83545 2.55068   -23.98013 1.000 32.87721 ? 1668 GLN A NE2  1 
ATOM   3359 H  H    . GLN A 1 209 ? -22.38244 0.28648   -21.67536 1.000 18.72202 ? 1668 GLN A H    1 
ATOM   3360 H  HA   . GLN A 1 209 ? -19.93896 0.43399   -22.60918 1.000 19.15793 ? 1668 GLN A HA   1 
ATOM   3361 H  HB2  . GLN A 1 209 ? -21.01303 1.81612   -20.39706 1.000 23.64273 ? 1668 GLN A HB2  1 
ATOM   3362 H  HB3  . GLN A 1 209 ? -19.61612 2.16228   -21.07104 1.000 23.64273 ? 1668 GLN A HB3  1 
ATOM   3363 H  HG2  . GLN A 1 209 ? -21.28837 3.69964   -21.65193 1.000 31.47807 ? 1668 GLN A HG2  1 
ATOM   3364 H  HG3  . GLN A 1 209 ? -20.65936 2.99278   -22.92869 1.000 31.47807 ? 1668 GLN A HG3  1 
ATOM   3365 H  HE21 . GLN A 1 209 ? -22.18006 2.78901   -24.48338 1.000 39.45266 ? 1668 GLN A HE21 1 
ATOM   3366 H  HE22 . GLN A 1 209 ? -23.59729 2.35722   -24.32908 1.000 39.45266 ? 1668 GLN A HE22 1 
ATOM   3367 N  N    . ASP A 1 210 ? -20.29463 -1.07017  -19.81056 1.000 12.48279 ? 1669 ASP A N    1 
ATOM   3368 C  CA   . ASP A 1 210 ? -19.64323 -2.04002  -18.92769 1.000 10.78268 ? 1669 ASP A CA   1 
ATOM   3369 C  C    . ASP A 1 210 ? -19.11204 -3.21996  -19.74110 1.000 11.83010 ? 1669 ASP A C    1 
ATOM   3370 O  O    . ASP A 1 210 ? -17.96190 -3.63642  -19.57931 1.000 11.14586 ? 1669 ASP A O    1 
ATOM   3371 C  CB   . ASP A 1 210 ? -20.60434 -2.55436  -17.86180 1.000 10.62214 ? 1669 ASP A CB   1 
ATOM   3372 C  CG   . ASP A 1 210 ? -20.91733 -1.53254  -16.77224 1.000 11.72751 ? 1669 ASP A CG   1 
ATOM   3373 O  OD1  . ASP A 1 210 ? -19.96854 -0.87524  -16.29137 1.000 12.56177 ? 1669 ASP A OD1  1 
ATOM   3374 O  OD2  . ASP A 1 210 ? -22.12169 -1.40504  -16.38112 1.000 12.74072 ? 1669 ASP A OD2  1 
ATOM   3375 H  H    . ASP A 1 210 ? -21.12264 -0.92503  -19.62910 1.000 14.97935 ? 1669 ASP A H    1 
ATOM   3376 H  HA   . ASP A 1 210 ? -18.91213 -1.59058  -18.47558 1.000 12.93922 ? 1669 ASP A HA   1 
ATOM   3377 H  HB2  . ASP A 1 210 ? -21.44107 -2.79860  -18.28739 1.000 12.74657 ? 1669 ASP A HB2  1 
ATOM   3378 H  HB3  . ASP A 1 210 ? -20.21035 -3.33099  -17.43456 1.000 12.74657 ? 1669 ASP A HB3  1 
ATOM   3379 N  N    . VAL A 1 211 ? -19.95759 -3.79922  -20.58506 1.000 12.07226 ? 1670 VAL A N    1 
ATOM   3380 C  CA   . VAL A 1 211 ? -19.56477 -4.94772  -21.37482 1.000 11.90122 ? 1670 VAL A CA   1 
ATOM   3381 C  C    . VAL A 1 211 ? -18.36897 -4.58691  -22.24033 1.000 11.71439 ? 1670 VAL A C    1 
ATOM   3382 O  O    . VAL A 1 211 ? -17.38357 -5.32242  -22.30500 1.000 12.27224 ? 1670 VAL A O    1 
ATOM   3383 C  CB   . VAL A 1 211 ? -20.76428 -5.44710  -22.18469 1.000 12.36969 ? 1670 VAL A CB   1 
ATOM   3384 C  CG1  . VAL A 1 211 ? -20.30516 -6.51570  -23.18235 1.000 12.96441 ? 1670 VAL A CG1  1 
ATOM   3385 C  CG2  . VAL A 1 211 ? -21.88422 -6.00740  -21.27878 1.000 12.29331 ? 1670 VAL A CG2  1 
ATOM   3386 H  H    . VAL A 1 211 ? -20.76774 -3.54266  -20.71708 1.000 14.48671 ? 1670 VAL A H    1 
ATOM   3387 H  HA   . VAL A 1 211 ? -19.28695 -5.67403  -20.79501 1.000 14.28146 ? 1670 VAL A HA   1 
ATOM   3388 H  HB   . VAL A 1 211 ? -21.13919 -4.69334  -22.66655 1.000 14.84363 ? 1670 VAL A HB   1 
ATOM   3389 H  HG11 . VAL A 1 211 ? -21.08075 -7.00118  -23.50431 1.000 15.55729 ? 1670 VAL A HG11 1 
ATOM   3390 H  HG12 . VAL A 1 211 ? -19.85473 -6.08244  -23.92417 1.000 15.55729 ? 1670 VAL A HG12 1 
ATOM   3391 H  HG13 . VAL A 1 211 ? -19.69613 -7.12416  -22.73541 1.000 15.55729 ? 1670 VAL A HG13 1 
ATOM   3392 H  HG21 . VAL A 1 211 ? -22.62064 -6.30598  -21.83505 1.000 14.75198 ? 1670 VAL A HG21 1 
ATOM   3393 H  HG22 . VAL A 1 211 ? -21.53306 -6.75272  -20.76683 1.000 14.75198 ? 1670 VAL A HG22 1 
ATOM   3394 H  HG23 . VAL A 1 211 ? -22.18545 -5.30696  -20.67916 1.000 14.75198 ? 1670 VAL A HG23 1 
ATOM   3395 N  N    . GLU A 1 212 ? -18.45924 -3.44795  -22.94766 1.000 12.54871 ? 1671 GLU A N    1 
ATOM   3396 C  CA   A GLU A 1 212 ? -17.37048 -3.04863  -23.81953 0.465 13.80144 ? 1671 GLU A CA   1 
ATOM   3397 C  CA   B GLU A 1 212 ? -17.37758 -3.00306  -23.81436 0.535 13.74354 ? 1671 GLU A CA   1 
ATOM   3398 C  C    . GLU A 1 212 ? -16.07546 -2.82757  -23.03484 1.000 13.24877 ? 1671 GLU A C    1 
ATOM   3399 O  O    . GLU A 1 212 ? -14.99157 -3.13539  -23.53179 1.000 14.39619 ? 1671 GLU A O    1 
ATOM   3400 C  CB   A GLU A 1 212 ? -17.78109 -1.82816  -24.63018 0.465 15.82272 ? 1671 GLU A CB   1 
ATOM   3401 C  CB   B GLU A 1 212 ? -17.80185 -1.69719  -24.47615 0.535 15.62007 ? 1671 GLU A CB   1 
ATOM   3402 C  CG   A GLU A 1 212 ? -18.76393 -2.17227  -25.76599 0.465 18.54146 ? 1671 GLU A CG   1 
ATOM   3403 C  CG   B GLU A 1 212 ? -16.69593 -0.86225  -25.11532 0.535 18.97834 ? 1671 GLU A CG   1 
ATOM   3404 C  CD   A GLU A 1 212 ? -19.37753 -0.96264  -26.45224 0.465 21.46808 ? 1671 GLU A CD   1 
ATOM   3405 C  CD   B GLU A 1 212 ? -17.21452 0.50316   -25.62016 0.535 21.66026 ? 1671 GLU A CD   1 
ATOM   3406 O  OE1  A GLU A 1 212 ? -18.94480 0.16904   -26.16419 0.465 23.45514 ? 1671 GLU A OE1  1 
ATOM   3407 O  OE1  B GLU A 1 212 ? -17.57281 1.38565   -24.79971 0.535 23.22617 ? 1671 GLU A OE1  1 
ATOM   3408 O  OE2  A GLU A 1 212 ? -20.31433 -1.16941  -27.28200 0.465 21.25752 ? 1671 GLU A OE2  1 
ATOM   3409 O  OE2  B GLU A 1 212 ? -17.28975 0.69278   -26.84211 0.535 23.51829 ? 1671 GLU A OE2  1 
ATOM   3410 H  H    A GLU A 1 212 ? -19.12875 -2.90835  -22.93377 0.465 15.05845 ? 1671 GLU A H    1 
ATOM   3411 H  H    B GLU A 1 212 ? -19.13860 -2.92072  -22.93805 0.535 15.05845 ? 1671 GLU A H    1 
ATOM   3412 H  HA   A GLU A 1 212 ? -17.18516 -3.75815  -24.45447 0.465 16.56173 ? 1671 GLU A HA   1 
ATOM   3413 H  HA   B GLU A 1 212 ? -17.20814 -3.66512  -24.50274 0.535 16.49225 ? 1671 GLU A HA   1 
ATOM   3414 H  HB2  A GLU A 1 212 ? -18.21303 -1.18900  -24.04212 0.465 18.98726 ? 1671 GLU A HB2  1 
ATOM   3415 H  HB2  B GLU A 1 212 ? -18.43859 -1.90845  -25.17674 0.535 18.74409 ? 1671 GLU A HB2  1 
ATOM   3416 H  HB3  A GLU A 1 212 ? -16.98978 -1.43169  -25.02710 0.465 18.98726 ? 1671 GLU A HB3  1 
ATOM   3417 H  HB3  B GLU A 1 212 ? -18.22289 -1.14154  -23.80170 0.535 18.74409 ? 1671 GLU A HB3  1 
ATOM   3418 H  HG2  A GLU A 1 212 ? -18.29074 -2.68349  -26.44101 0.465 22.24976 ? 1671 GLU A HG2  1 
ATOM   3419 H  HG2  B GLU A 1 212 ? -16.00111 -0.69795  -24.45872 0.535 22.77401 ? 1671 GLU A HG2  1 
ATOM   3420 H  HG3  A GLU A 1 212 ? -19.48987 -2.70022  -25.39831 0.465 22.24976 ? 1671 GLU A HG3  1 
ATOM   3421 H  HG3  B GLU A 1 212 ? -16.32941 -1.34533  -25.87241 0.535 22.77401 ? 1671 GLU A HG3  1 
ATOM   3422 N  N    . ALA A 1 213 ? -16.16558 -2.30854  -21.81870 1.000 12.94873 ? 1672 ALA A N    1 
ATOM   3423 C  CA   . ALA A 1 213 ? -14.98755 -2.07873  -21.00787 1.000 12.74337 ? 1672 ALA A CA   1 
ATOM   3424 C  C    . ALA A 1 213 ? -14.31476 -3.39367  -20.62697 1.000 11.86696 ? 1672 ALA A C    1 
ATOM   3425 O  O    . ALA A 1 213 ? -13.08655 -3.46382  -20.57232 1.000 12.09333 ? 1672 ALA A O    1 
ATOM   3426 C  CB   . ALA A 1 213 ? -15.31515 -1.27865  -19.76965 1.000 12.64599 ? 1672 ALA A CB   1 
ATOM   3427 H  H    . ALA A 1 213 ? -16.90255 -2.07992  -21.43895 1.000 15.53847 ? 1672 ALA A H    1 
ATOM   3428 H  HA   . ALA A 1 213 ? -14.36575 -1.55106  -21.53308 1.000 15.29204 ? 1672 ALA A HA   1 
ATOM   3429 H  HB1  . ALA A 1 213 ? -14.50518 -1.15406  -19.25069 1.000 15.17519 ? 1672 ALA A HB1  1 
ATOM   3430 H  HB2  . ALA A 1 213 ? -15.67326 -0.41735  -20.03577 1.000 15.17519 ? 1672 ALA A HB2  1 
ATOM   3431 H  HB3  . ALA A 1 213 ? -15.97254 -1.76261  -19.24570 1.000 15.17519 ? 1672 ALA A HB3  1 
ATOM   3432 N  N    . LEU A 1 214 ? -15.09305 -4.43374  -20.31200 1.000 11.35640 ? 1673 LEU A N    1 
ATOM   3433 C  CA   . LEU A 1 214 ? -14.47378 -5.72332  -19.99730 1.000 11.01428 ? 1673 LEU A CA   1 
ATOM   3434 C  C    . LEU A 1 214 ? -13.73126 -6.27579  -21.21328 1.000 11.26423 ? 1673 LEU A C    1 
ATOM   3435 O  O    . LEU A 1 214 ? -12.58344 -6.73570  -21.08213 1.000 11.69063 ? 1673 LEU A O    1 
ATOM   3436 C  CB   . LEU A 1 214 ? -15.55068 -6.67634  -19.45571 1.000 9.63776  ? 1673 LEU A CB   1 
ATOM   3437 C  CG   . LEU A 1 214 ? -16.23884 -6.25371  -18.16946 1.000 10.18791 ? 1673 LEU A CG   1 
ATOM   3438 C  CD1  . LEU A 1 214 ? -17.33256 -7.29061  -17.85367 1.000 10.47466 ? 1673 LEU A CD1  1 
ATOM   3439 C  CD2  . LEU A 1 214 ? -15.30958 -6.15852  -17.01351 1.000 11.33525 ? 1673 LEU A CD2  1 
ATOM   3440 H  H    . LEU A 1 214 ? -15.95212 -4.41953  -20.27468 1.000 13.62769 ? 1673 LEU A H    1 
ATOM   3441 H  HA   . LEU A 1 214 ? -13.80953 -5.62502  -19.29730 1.000 13.21713 ? 1673 LEU A HA   1 
ATOM   3442 H  HB2  . LEU A 1 214 ? -16.23999 -6.76731  -20.13208 1.000 11.56532 ? 1673 LEU A HB2  1 
ATOM   3443 H  HB3  . LEU A 1 214 ? -15.13482 -7.53649  -19.28806 1.000 11.56532 ? 1673 LEU A HB3  1 
ATOM   3444 H  HG   . LEU A 1 214 ? -16.61014 -5.36661  -18.29631 1.000 12.22550 ? 1673 LEU A HG   1 
ATOM   3445 H  HD11 . LEU A 1 214 ? -17.78108 -7.03626  -17.03206 1.000 12.56959 ? 1673 LEU A HD11 1 
ATOM   3446 H  HD12 . LEU A 1 214 ? -17.96907 -7.31103  -18.58534 1.000 12.56959 ? 1673 LEU A HD12 1 
ATOM   3447 H  HD13 . LEU A 1 214 ? -16.92046 -8.16249  -17.74931 1.000 12.56959 ? 1673 LEU A HD13 1 
ATOM   3448 H  HD21 . LEU A 1 214 ? -15.82008 -5.95712  -16.21368 1.000 13.60231 ? 1673 LEU A HD21 1 
ATOM   3449 H  HD22 . LEU A 1 214 ? -14.84944 -7.00585  -16.90762 1.000 13.60231 ? 1673 LEU A HD22 1 
ATOM   3450 H  HD23 . LEU A 1 214 ? -14.66685 -5.45192  -17.18236 1.000 13.60231 ? 1673 LEU A HD23 1 
ATOM   3451 N  N    . TRP A 1 215 ? -14.34506 -6.22401  -22.39718 1.000 10.82216 ? 1674 TRP A N    1 
ATOM   3452 C  CA   . TRP A 1 215 ? -13.67804 -6.67115  -23.61470 1.000 11.01421 ? 1674 TRP A CA   1 
ATOM   3453 C  C    . TRP A 1 215 ? -12.41754 -5.86189  -23.87430 1.000 10.45641 ? 1674 TRP A C    1 
ATOM   3454 O  O    . TRP A 1 215 ? -11.35961 -6.41776  -24.18912 1.000 12.95387 ? 1674 TRP A O    1 
ATOM   3455 C  CB   . TRP A 1 215 ? -14.62267 -6.63948  -24.81202 1.000 11.14838 ? 1674 TRP A CB   1 
ATOM   3456 C  CG   . TRP A 1 215 ? -15.58865 -7.80496  -24.80238 1.000 11.08802 ? 1674 TRP A CG   1 
ATOM   3457 C  CD1  . TRP A 1 215 ? -16.89206 -7.77912  -24.44526 1.000 11.96957 ? 1674 TRP A CD1  1 
ATOM   3458 C  CD2  . TRP A 1 215 ? -15.29988 -9.16602  -25.16548 1.000 12.18811 ? 1674 TRP A CD2  1 
ATOM   3459 N  NE1  . TRP A 1 215 ? -17.44224 -9.02630  -24.51369 1.000 11.68277 ? 1674 TRP A NE1  1 
ATOM   3460 C  CE2  . TRP A 1 215 ? -16.49138 -9.90555  -24.96927 1.000 12.88025 ? 1674 TRP A CE2  1 
ATOM   3461 C  CE3  . TRP A 1 215 ? -14.15548 -9.82195  -25.65506 1.000 13.08816 ? 1674 TRP A CE3  1 
ATOM   3462 C  CZ2  . TRP A 1 215 ? -16.54983 -11.25351 -25.23970 1.000 13.32766 ? 1674 TRP A CZ2  1 
ATOM   3463 C  CZ3  . TRP A 1 215 ? -14.23711 -11.16230 -25.88679 1.000 13.72503 ? 1674 TRP A CZ3  1 
ATOM   3464 C  CH2  . TRP A 1 215 ? -15.40678 -11.86329 -25.68213 1.000 13.95667 ? 1674 TRP A CH2  1 
ATOM   3465 H  H    . TRP A 1 215 ? -15.14552 -5.93470  -22.52032 1.000 12.98659 ? 1674 TRP A H    1 
ATOM   3466 H  HA   . TRP A 1 215 ? -13.41943 -7.59840  -23.49545 1.000 13.21705 ? 1674 TRP A HA   1 
ATOM   3467 H  HB2  . TRP A 1 215 ? -15.13794 -5.81795  -24.78995 1.000 13.37806 ? 1674 TRP A HB2  1 
ATOM   3468 H  HB3  . TRP A 1 215 ? -14.10260 -6.68303  -25.62966 1.000 13.37806 ? 1674 TRP A HB3  1 
ATOM   3469 H  HD1  . TRP A 1 215 ? -17.35262 -7.01347  -24.18728 1.000 14.36349 ? 1674 TRP A HD1  1 
ATOM   3470 H  HE1  . TRP A 1 215 ? -18.25186 -9.22826  -24.30553 1.000 14.01933 ? 1674 TRP A HE1  1 
ATOM   3471 H  HE3  . TRP A 1 215 ? -13.36739 -9.35501  -25.81561 1.000 15.70579 ? 1674 TRP A HE3  1 
ATOM   3472 H  HZ2  . TRP A 1 215 ? -17.33824 -11.73347 -25.12590 1.000 15.99319 ? 1674 TRP A HZ2  1 
ATOM   3473 H  HZ3  . TRP A 1 215 ? -13.48441 -11.61605 -26.19086 1.000 16.47004 ? 1674 TRP A HZ3  1 
ATOM   3474 H  HH2  . TRP A 1 215 ? -15.41953 -12.77797 -25.84974 1.000 16.74800 ? 1674 TRP A HH2  1 
ATOM   3475 N  N    . GLU A 1 216 ? -12.51977 -4.53513  -23.75487 1.000 11.96699 ? 1675 GLU A N    1 
ATOM   3476 C  CA   A GLU A 1 216 ? -11.36312 -3.70080  -24.06040 0.539 12.48291 ? 1675 GLU A CA   1 
ATOM   3477 C  CA   B GLU A 1 216 ? -11.37534 -3.67028  -24.03623 0.461 11.86177 ? 1675 GLU A CA   1 
ATOM   3478 C  C    . GLU A 1 216 ? -10.22810 -3.97213  -23.08978 1.000 12.15122 ? 1675 GLU A C    1 
ATOM   3479 O  O    . GLU A 1 216 ? -9.03780  -3.82309  -23.46057 1.000 13.34341 ? 1675 GLU A O    1 
ATOM   3480 C  CB   A GLU A 1 216 ? -11.75992 -2.22532  -24.04029 0.539 15.70956 ? 1675 GLU A CB   1 
ATOM   3481 C  CB   B GLU A 1 216 ? -11.80727 -2.20731  -23.87509 0.461 13.63827 ? 1675 GLU A CB   1 
ATOM   3482 C  CG   A GLU A 1 216 ? -12.59806 -1.84391  -25.24978 0.539 19.03364 ? 1675 GLU A CG   1 
ATOM   3483 C  CG   B GLU A 1 216 ? -10.69988 -1.16405  -23.99434 0.461 15.78330 ? 1675 GLU A CG   1 
ATOM   3484 C  CD   A GLU A 1 216 ? -13.01151 -0.37498  -25.26653 0.539 23.14459 ? 1675 GLU A CD   1 
ATOM   3485 C  CD   B GLU A 1 216 ? -10.07903 -1.09873  -25.36817 0.461 19.47054 ? 1675 GLU A CD   1 
ATOM   3486 O  OE1  A GLU A 1 216 ? -12.61012 0.38426   -24.35394 0.539 24.37633 ? 1675 GLU A OE1  1 
ATOM   3487 O  OE1  B GLU A 1 216 ? -10.77052 -1.44751  -26.35276 0.461 21.09431 ? 1675 GLU A OE1  1 
ATOM   3488 O  OE2  A GLU A 1 216 ? -13.72659 0.02250   -26.21559 0.539 25.04476 ? 1675 GLU A OE2  1 
ATOM   3489 O  OE2  B GLU A 1 216 ? -8.89774  -0.68667  -25.46873 0.461 22.26810 ? 1675 GLU A OE2  1 
ATOM   3490 H  H    A GLU A 1 216 ? -13.22496 -4.10988  -23.50695 0.539 14.36039 ? 1675 GLU A H    1 
ATOM   3491 H  H    B GLU A 1 216 ? -13.23198 -4.11672  -23.51552 0.461 14.36039 ? 1675 GLU A H    1 
ATOM   3492 H  HA   A GLU A 1 216 ? -11.04723 -3.90210  -24.95516 0.539 14.97949 ? 1675 GLU A HA   1 
ATOM   3493 H  HA   B GLU A 1 216 ? -11.07096 -3.81138  -24.94636 0.461 14.23413 ? 1675 GLU A HA   1 
ATOM   3494 H  HB2  A GLU A 1 216 ? -12.28055 -2.04639  -23.24165 0.539 18.85148 ? 1675 GLU A HB2  1 
ATOM   3495 H  HB2  B GLU A 1 216 ? -12.46335 -2.00798  -24.56118 0.461 16.36592 ? 1675 GLU A HB2  1 
ATOM   3496 H  HB3  A GLU A 1 216 ? -10.95788 -1.67977  -24.04261 0.539 18.85148 ? 1675 GLU A HB3  1 
ATOM   3497 H  HB3  B GLU A 1 216 ? -12.20445 -2.10392  -22.99619 0.461 16.36592 ? 1675 GLU A HB3  1 
ATOM   3498 H  HG2  A GLU A 1 216 ? -12.08383 -2.01643  -26.05396 0.539 22.84037 ? 1675 GLU A HG2  1 
ATOM   3499 H  HG2  B GLU A 1 216 ? -11.07018 -0.29011  -23.79431 0.461 18.93996 ? 1675 GLU A HG2  1 
ATOM   3500 H  HG3  A GLU A 1 216 ? -13.40671 -2.37962  -25.25178 0.539 22.84037 ? 1675 GLU A HG3  1 
ATOM   3501 H  HG3  B GLU A 1 216 ? -9.99726  -1.37947  -23.36123 0.461 18.93996 ? 1675 GLU A HG3  1 
ATOM   3502 N  N    . ASN A 1 217 ? -10.55059 -4.38288  -21.86980 1.000 11.46958 ? 1676 ASN A N    1 
ATOM   3503 C  CA   . ASN A 1 217 ? -9.59180  -4.66421  -20.80555 1.000 10.53265 ? 1676 ASN A CA   1 
ATOM   3504 C  C    . ASN A 1 217 ? -9.40075  -6.16096  -20.59129 1.000 10.61418 ? 1676 ASN A C    1 
ATOM   3505 O  O    . ASN A 1 217 ? -9.07222  -6.58890  -19.49098 1.000 11.55640 ? 1676 ASN A O    1 
ATOM   3506 C  CB   . ASN A 1 217 ? -9.98018  -3.96909  -19.52186 1.000 12.05648 ? 1676 ASN A CB   1 
ATOM   3507 C  CG   . ASN A 1 217 ? -9.81262  -2.49750  -19.62427 1.000 13.07767 ? 1676 ASN A CG   1 
ATOM   3508 O  OD1  . ASN A 1 217 ? -8.67009  -2.02898  -19.61549 1.000 14.73829 ? 1676 ASN A OD1  1 
ATOM   3509 N  ND2  . ASN A 1 217 ? -10.91415 -1.75796  -19.80403 1.000 14.08565 ? 1676 ASN A ND2  1 
ATOM   3510 H  H    . ASN A 1 217 ? -11.36285 -4.51354  -21.61929 1.000 13.76349 ? 1676 ASN A H    1 
ATOM   3511 H  HA   . ASN A 1 217 ? -8.73248  -4.29706  -21.06569 1.000 12.63918 ? 1676 ASN A HA   1 
ATOM   3512 H  HB2  . ASN A 1 217 ? -10.91122 -4.15680  -19.32482 1.000 14.46777 ? 1676 ASN A HB2  1 
ATOM   3513 H  HB3  . ASN A 1 217 ? -9.41706  -4.29044  -18.80039 1.000 14.46777 ? 1676 ASN A HB3  1 
ATOM   3514 H  HD21 . ASN A 1 217 ? -10.85216 -0.90254  -19.86739 1.000 16.90278 ? 1676 ASN A HD21 1 
ATOM   3515 H  HD22 . ASN A 1 217 ? -11.68369 -2.13836  -19.85614 1.000 16.90278 ? 1676 ASN A HD22 1 
ATOM   3516 N  N    . MET A 1 218 ? -9.49190  -6.93585  -21.67283 1.000 10.57206 ? 1677 MET A N    1 
ATOM   3517 C  CA   . MET A 1 218 ? -9.24989  -8.38277  -21.58648 1.000 10.85376 ? 1677 MET A CA   1 
ATOM   3518 C  C    . MET A 1 218 ? -7.91349  -8.70698  -20.91645 1.000 10.67731 ? 1677 MET A C    1 
ATOM   3519 O  O    . MET A 1 218 ? -7.79567  -9.69330  -20.18070 1.000 10.27208 ? 1677 MET A O    1 
ATOM   3520 C  CB   . MET A 1 218 ? -9.26415  -8.97708  -22.98725 1.000 12.35912 ? 1677 MET A CB   1 
ATOM   3521 C  CG   . MET A 1 218 ? -9.27882  -10.50261 -23.10073 1.000 13.70130 ? 1677 MET A CG   1 
ATOM   3522 S  SD   . MET A 1 218 ? -10.49057 -11.39730 -22.09852 1.000 13.48316 ? 1677 MET A SD   1 
ATOM   3523 C  CE   . MET A 1 218 ? -11.99647 -10.78401 -22.83501 1.000 16.67789 ? 1677 MET A CE   1 
ATOM   3524 H  H    . MET A 1 218 ? -9.68984  -6.65575  -22.46148 1.000 12.68647 ? 1677 MET A H    1 
ATOM   3525 H  HA   . MET A 1 218 ? -9.96383  -8.77485  -21.05974 1.000 13.02451 ? 1677 MET A HA   1 
ATOM   3526 H  HB2  . MET A 1 218 ? -10.05868 -8.65387  -23.44020 1.000 14.83094 ? 1677 MET A HB2  1 
ATOM   3527 H  HB3  . MET A 1 218 ? -8.46962  -8.66840  -23.45021 1.000 14.83094 ? 1677 MET A HB3  1 
ATOM   3528 H  HG2  . MET A 1 218 ? -9.45682  -10.73134 -24.02642 1.000 16.44156 ? 1677 MET A HG2  1 
ATOM   3529 H  HG3  . MET A 1 218 ? -8.40346  -10.82967 -22.84060 1.000 16.44156 ? 1677 MET A HG3  1 
ATOM   3530 H  HE1  . MET A 1 218 ? -12.75516 -11.18871 -22.38613 1.000 20.01347 ? 1677 MET A HE1  1 
ATOM   3531 H  HE2  . MET A 1 218 ? -12.02780 -9.81985  -22.73348 1.000 20.01347 ? 1677 MET A HE2  1 
ATOM   3532 H  HE3  . MET A 1 218 ? -12.00571 -11.01797 -23.77633 1.000 20.01347 ? 1677 MET A HE3  1 
ATOM   3533 N  N    . ALA A 1 219 ? -6.87097  -7.89292  -21.16916 1.000 10.57740 ? 1678 ALA A N    1 
ATOM   3534 C  CA   . ALA A 1 219 ? -5.56864  -8.17030  -20.60767 1.000 11.75911 ? 1678 ALA A CA   1 
ATOM   3535 C  C    . ALA A 1 219 ? -5.56722  -8.14304  -19.09414 1.000 11.57482 ? 1678 ALA A C    1 
ATOM   3536 O  O    . ALA A 1 219 ? -4.66542  -8.72826  -18.49817 1.000 12.99598 ? 1678 ALA A O    1 
ATOM   3537 C  CB   . ALA A 1 219 ? -4.55762  -7.10711  -21.11213 1.000 14.34347 ? 1678 ALA A CB   1 
ATOM   3538 H  H    . ALA A 1 219 ? -6.90632  -7.18636  -21.65816 1.000 12.69288 ? 1678 ALA A H    1 
ATOM   3539 H  HA   . ALA A 1 219 ? -5.29349  -9.05361  -20.89912 1.000 14.11094 ? 1678 ALA A HA   1 
ATOM   3540 H  HB1  . ALA A 1 219 ? -3.68486  -7.29662  -20.73363 1.000 17.21216 ? 1678 ALA A HB1  1 
ATOM   3541 H  HB2  . ALA A 1 219 ? -4.51405  -7.14711  -22.08033 1.000 17.21216 ? 1678 ALA A HB2  1 
ATOM   3542 H  HB3  . ALA A 1 219 ? -4.85658  -6.22836  -20.83050 1.000 17.21216 ? 1678 ALA A HB3  1 
ATOM   3543 N  N    . VAL A 1 220 ? -6.52910  -7.46166  -18.46021 1.000 10.27476 ? 1679 VAL A N    1 
ATOM   3544 C  CA   . VAL A 1 220 ? -6.66244  -7.40606  -17.01280 1.000 10.58786 ? 1679 VAL A CA   1 
ATOM   3545 C  C    . VAL A 1 220 ? -7.37084  -8.61706  -16.45885 1.000 8.87720  ? 1679 VAL A C    1 
ATOM   3546 O  O    . VAL A 1 220 ? -7.33014  -8.85208  -15.24680 1.000 9.62193  ? 1679 VAL A O    1 
ATOM   3547 C  CB   . VAL A 1 220 ? -7.42976  -6.08017  -16.66959 1.000 11.52490 ? 1679 VAL A CB   1 
ATOM   3548 C  CG1  . VAL A 1 220 ? -7.55970  -5.83647  -15.17201 1.000 12.91176 ? 1679 VAL A CG1  1 
ATOM   3549 C  CG2  . VAL A 1 220 ? -6.75686  -4.87424  -17.34160 1.000 13.69081 ? 1679 VAL A CG2  1 
ATOM   3550 H  H    . VAL A 1 220 ? -7.13694  -7.00805  -18.86563 1.000 12.32971 ? 1679 VAL A H    1 
ATOM   3551 H  HA   . VAL A 1 220 ? -5.79203  -7.39891  -16.58474 1.000 12.70543 ? 1679 VAL A HA   1 
ATOM   3552 H  HB   . VAL A 1 220 ? -8.32990  -6.18128  -17.01662 1.000 13.82988 ? 1679 VAL A HB   1 
ATOM   3553 H  HG11 . VAL A 1 220 ? -7.96056  -4.96508  -15.02746 1.000 15.49411 ? 1679 VAL A HG11 1 
ATOM   3554 H  HG12 . VAL A 1 220 ? -8.12179  -6.52707  -14.78727 1.000 15.49411 ? 1679 VAL A HG12 1 
ATOM   3555 H  HG13 . VAL A 1 220 ? -6.67759  -5.86564  -14.76960 1.000 15.49411 ? 1679 VAL A HG13 1 
ATOM   3556 H  HG21 . VAL A 1 220 ? -7.18034  -4.06033  -17.02679 1.000 16.42897 ? 1679 VAL A HG21 1 
ATOM   3557 H  HG22 . VAL A 1 220 ? -5.81506  -4.86821  -17.10946 1.000 16.42897 ? 1679 VAL A HG22 1 
ATOM   3558 H  HG23 . VAL A 1 220 ? -6.86006  -4.95026  -18.30309 1.000 16.42897 ? 1679 VAL A HG23 1 
ATOM   3559 N  N    . ILE A 1 221 ? -8.11371  -9.34749  -17.29312 1.000 9.24297  ? 1680 ILE A N    1 
ATOM   3560 C  CA   . ILE A 1 221 ? -8.92808  -10.48366 -16.82551 1.000 9.37717  ? 1680 ILE A CA   1 
ATOM   3561 C  C    . ILE A 1 221 ? -8.03633  -11.72967 -16.74464 1.000 7.92709  ? 1680 ILE A C    1 
ATOM   3562 O  O    . ILE A 1 221 ? -7.53332  -12.19814 -17.77436 1.000 9.38504  ? 1680 ILE A O    1 
ATOM   3563 C  CB   . ILE A 1 221 ? -10.10638 -10.69683 -17.76607 1.000 9.29303  ? 1680 ILE A CB   1 
ATOM   3564 C  CG1  . ILE A 1 221 ? -11.01354 -9.46781  -17.84617 1.000 9.76147  ? 1680 ILE A CG1  1 
ATOM   3565 C  CG2  . ILE A 1 221 ? -10.88549 -11.94376 -17.38081 1.000 9.81146  ? 1680 ILE A CG2  1 
ATOM   3566 C  CD1  . ILE A 1 221 ? -12.09342 -9.61745  -18.90607 1.000 11.63528 ? 1680 ILE A CD1  1 
ATOM   3567 H  H    . ILE A 1 221 ? -8.16598  -9.20759  -18.14005 1.000 11.09156 ? 1680 ILE A H    1 
ATOM   3568 H  HA   . ILE A 1 221 ? -9.26342  -10.31001 -15.93204 1.000 11.25260 ? 1680 ILE A HA   1 
ATOM   3569 H  HB   . ILE A 1 221 ? -9.74273  -10.82928 -18.65551 1.000 11.15163 ? 1680 ILE A HB   1 
ATOM   3570 H  HG12 . ILE A 1 221 ? -11.44753 -9.33684  -16.98861 1.000 11.71377 ? 1680 ILE A HG12 1 
ATOM   3571 H  HG13 . ILE A 1 221 ? -10.47704 -8.69090  -18.06858 1.000 11.71377 ? 1680 ILE A HG13 1 
ATOM   3572 H  HG21 . ILE A 1 221 ? -11.66768 -12.01581 -17.94992 1.000 11.77375 ? 1680 ILE A HG21 1 
ATOM   3573 H  HG22 . ILE A 1 221 ? -10.31706 -12.72067 -17.49993 1.000 11.77375 ? 1680 ILE A HG22 1 
ATOM   3574 H  HG23 . ILE A 1 221 ? -11.15736 -11.87201 -16.45246 1.000 11.77375 ? 1680 ILE A HG23 1 
ATOM   3575 H  HD11 . ILE A 1 221 ? -12.48149 -8.74699  -19.08662 1.000 13.96234 ? 1680 ILE A HD11 1 
ATOM   3576 H  HD12 . ILE A 1 221 ? -11.69494 -9.97608  -19.71446 1.000 13.96234 ? 1680 ILE A HD12 1 
ATOM   3577 H  HD13 . ILE A 1 221 ? -12.77669 -10.22253 -18.57754 1.000 13.96234 ? 1680 ILE A HD13 1 
ATOM   3578 N  N    . ASP A 1 222 ? -7.84847  -12.25366 -15.54138 1.000 8.52708  ? 1681 ASP A N    1 
ATOM   3579 C  CA   . ASP A 1 222 ? -6.99096  -13.45608 -15.39609 1.000 9.10872  ? 1681 ASP A CA   1 
ATOM   3580 C  C    . ASP A 1 222 ? -7.71299  -14.75096 -15.75230 1.000 8.94558  ? 1681 ASP A C    1 
ATOM   3581 O  O    . ASP A 1 222 ? -7.10485  -15.62986 -16.37864 1.000 8.96661  ? 1681 ASP A O    1 
ATOM   3582 C  CB   . ASP A 1 222 ? -6.47087  -13.56014 -13.97036 1.000 9.18511  ? 1681 ASP A CB   1 
ATOM   3583 C  CG   . ASP A 1 222 ? -5.67539  -12.33676 -13.58675 1.000 10.13257 ? 1681 ASP A CG   1 
ATOM   3584 O  OD1  . ASP A 1 222 ? -4.46618  -12.32601 -13.92432 1.000 11.93533 ? 1681 ASP A OD1  1 
ATOM   3585 O  OD2  . ASP A 1 222 ? -6.26833  -11.44053 -12.95983 1.000 9.48509  ? 1681 ASP A OD2  1 
ATOM   3586 H  H    . ASP A 1 222 ? -8.18736  -11.95391 -14.81001 1.000 10.23250 ? 1681 ASP A H    1 
ATOM   3587 H  HA   . ASP A 1 222 ? -6.24512  -13.34967 -16.00707 1.000 10.93047 ? 1681 ASP A HA   1 
ATOM   3588 H  HB2  . ASP A 1 222 ? -7.22012  -13.64199 -13.35976 1.000 11.02213 ? 1681 ASP A HB2  1 
ATOM   3589 H  HB3  . ASP A 1 222 ? -5.89437  -14.33650 -13.89406 1.000 11.02213 ? 1681 ASP A HB3  1 
ATOM   3590 N  N    . CYS A 1 223 ? -8.99664  -14.85778 -15.39186 1.000 8.79818  ? 1682 CYS A N    1 
ATOM   3591 C  CA   . CYS A 1 223 ? -9.74917  -16.09914 -15.57127 1.000 8.80086  ? 1682 CYS A CA   1 
ATOM   3592 C  C    . CYS A 1 223 ? -11.12923 -15.77212 -16.12868 1.000 8.79292  ? 1682 CYS A C    1 
ATOM   3593 O  O    . CYS A 1 223 ? -11.69212 -14.70844 -15.86988 1.000 8.70871  ? 1682 CYS A O    1 
ATOM   3594 C  CB   . CYS A 1 223 ? -9.97401  -16.85267 -14.26753 1.000 9.62979  ? 1682 CYS A CB   1 
ATOM   3595 S  SG   . CYS A 1 223 ? -8.44662  -17.31902 -13.37273 1.000 10.42454 ? 1682 CYS A SG   1 
ATOM   3596 H  H    . CYS A 1 223 ? -9.45392  -14.22030 -15.03955 1.000 10.55782 ? 1682 CYS A H    1 
ATOM   3597 H  HA   . CYS A 1 223 ? -9.24824  -16.65836 -16.18548 1.000 10.56103 ? 1682 CYS A HA   1 
ATOM   3598 H  HB2  . CYS A 1 223 ? -10.49885 -16.29182 -13.67517 1.000 11.55575 ? 1682 CYS A HB2  1 
ATOM   3599 H  HB3  . CYS A 1 223 ? -10.45719 -17.67032 -14.46474 1.000 11.55575 ? 1682 CYS A HB3  1 
ATOM   3600 H  HG   . CYS A 1 223 ? -8.74588  -17.88043 -12.35526 1.000 12.50944 ? 1682 CYS A HG   1 
ATOM   3601 N  N    . PHE A 1 224 ? -11.70396 -16.74264 -16.84174 1.000 8.69554  ? 1683 PHE A N    1 
ATOM   3602 C  CA   . PHE A 1 224 ? -13.15977 -16.82607 -17.00511 1.000 8.40865  ? 1683 PHE A CA   1 
ATOM   3603 C  C    . PHE A 1 224 ? -13.66104 -17.85368 -15.99777 1.000 8.64556  ? 1683 PHE A C    1 
ATOM   3604 O  O    . PHE A 1 224 ? -12.99480 -18.85545 -15.72418 1.000 10.28251 ? 1683 PHE A O    1 
ATOM   3605 C  CB   . PHE A 1 224 ? -13.53585 -17.21978 -18.41879 1.000 9.38505  ? 1683 PHE A CB   1 
ATOM   3606 C  CG   . PHE A 1 224 ? -13.06719 -16.28102 -19.48536 1.000 9.20618  ? 1683 PHE A CG   1 
ATOM   3607 C  CD1  . PHE A 1 224 ? -13.29518 -14.90880 -19.39374 1.000 10.24312 ? 1683 PHE A CD1  1 
ATOM   3608 C  CD2  . PHE A 1 224 ? -12.42774 -16.75491 -20.60718 1.000 9.64827  ? 1683 PHE A CD2  1 
ATOM   3609 C  CE1  . PHE A 1 224 ? -12.88463 -14.04156 -20.38600 1.000 10.29309 ? 1683 PHE A CE1  1 
ATOM   3610 C  CE2  . PHE A 1 224 ? -12.04155 -15.90194 -21.60655 1.000 10.22990 ? 1683 PHE A CE2  1 
ATOM   3611 C  CZ   . PHE A 1 224 ? -12.27331 -14.52381 -21.51425 1.000 10.06146 ? 1683 PHE A CZ   1 
ATOM   3612 H  H    . PHE A 1 224 ? -11.27069 -17.36794 -17.24284 1.000 10.43465 ? 1683 PHE A H    1 
ATOM   3613 H  HA   . PHE A 1 224 ? -13.58583 -15.96997 -16.84242 1.000 10.09038 ? 1683 PHE A HA   1 
ATOM   3614 H  HB2  . PHE A 1 224 ? -13.15021 -18.08954 -18.60772 1.000 11.26206 ? 1683 PHE A HB2  1 
ATOM   3615 H  HB3  . PHE A 1 224 ? -14.50299 -17.26590 -18.47722 1.000 11.26206 ? 1683 PHE A HB3  1 
ATOM   3616 H  HD1  . PHE A 1 224 ? -13.73391 -14.56994 -18.64702 1.000 12.29174 ? 1683 PHE A HD1  1 
ATOM   3617 H  HD2  . PHE A 1 224 ? -12.25564 -17.66527 -20.68796 1.000 11.57792 ? 1683 PHE A HD2  1 
ATOM   3618 H  HE1  . PHE A 1 224 ? -13.02319 -13.12709 -20.28881 1.000 12.35171 ? 1683 PHE A HE1  1 
ATOM   3619 H  HE2  . PHE A 1 224 ? -11.61763 -16.24408 -22.36029 1.000 12.27588 ? 1683 PHE A HE2  1 
ATOM   3620 H  HZ   . PHE A 1 224 ? -12.01897 -13.95045 -22.20088 1.000 12.07375 ? 1683 PHE A HZ   1 
ATOM   3621 N  N    . ALA A 1 225 ? -14.85316 -17.62488 -15.44301 1.000 8.17187  ? 1684 ALA A N    1 
ATOM   3622 C  CA   . ALA A 1 225 ? -15.43945 -18.56441 -14.50356 1.000 9.47977  ? 1684 ALA A CA   1 
ATOM   3623 C  C    . ALA A 1 225 ? -16.94515 -18.34406 -14.60044 1.000 8.52982  ? 1684 ALA A C    1 
ATOM   3624 O  O    . ALA A 1 225 ? -17.39011 -17.19391 -14.65252 1.000 10.25092 ? 1684 ALA A O    1 
ATOM   3625 C  CB   . ALA A 1 225 ? -14.92915 -18.36019 -13.08079 1.000 9.74299  ? 1684 ALA A CB   1 
ATOM   3626 H  H    . ALA A 1 225 ? -15.33714 -16.93120 -15.59848 1.000 9.80625  ? 1684 ALA A H    1 
ATOM   3627 H  HA   . ALA A 1 225 ? -15.22020 -19.48262 -14.72655 1.000 11.37573 ? 1684 ALA A HA   1 
ATOM   3628 H  HB1  . ALA A 1 225 ? -15.33975 -19.01997 -12.50027 1.000 11.69159 ? 1684 ALA A HB1  1 
ATOM   3629 H  HB2  . ALA A 1 225 ? -13.96506 -18.46676 -13.07273 1.000 11.69159 ? 1684 ALA A HB2  1 
ATOM   3630 H  HB3  . ALA A 1 225 ? -15.16568 -17.46697 -12.78562 1.000 11.69159 ? 1684 ALA A HB3  1 
ATOM   3631 N  N    . SER A 1 226 ? -17.71351 -19.42736 -14.61833 1.000 9.09298  ? 1685 SER A N    1 
ATOM   3632 C  CA   . SER A 1 226 ? -19.12685 -19.25832 -15.00106 1.000 9.73246  ? 1685 SER A CA   1 
ATOM   3633 C  C    . SER A 1 226 ? -19.97193 -18.57039 -13.95560 1.000 9.07716  ? 1685 SER A C    1 
ATOM   3634 O  O    . SER A 1 226 ? -20.99083 -17.93250 -14.30317 1.000 9.19294  ? 1685 SER A O    1 
ATOM   3635 C  CB   . SER A 1 226 ? -19.79029 -20.62214 -15.29781 1.000 9.79306  ? 1685 SER A CB   1 
ATOM   3636 O  OG   . SER A 1 226 ? -19.75806 -21.47197 -14.16837 1.000 10.69310 ? 1685 SER A OG   1 
ATOM   3637 H  H    . SER A 1 226 ? -17.46434 -20.22772 -14.42617 1.000 10.91157 ? 1685 SER A H    1 
ATOM   3638 H  HA   . SER A 1 226 ? -19.10957 -18.70896 -15.80031 1.000 11.67895 ? 1685 SER A HA   1 
ATOM   3639 H  HB2  . SER A 1 226 ? -20.71477 -20.47209 -15.55025 1.000 11.75168 ? 1685 SER A HB2  1 
ATOM   3640 H  HB3  . SER A 1 226 ? -19.31302 -21.05057 -16.02552 1.000 11.75168 ? 1685 SER A HB3  1 
ATOM   3641 H  HG   . SER A 1 226 ? -18.96248 -21.62371 -13.94562 1.000 12.83171 ? 1685 SER A HG   1 
ATOM   3642 N  N    . ASP A 1 227 ? -19.63425 -18.72133 -12.68351 1.000 9.04554  ? 1686 ASP A N    1 
ATOM   3643 C  CA   . ASP A 1 227 ? -20.59727 -18.44982 -11.59463 1.000 8.01921  ? 1686 ASP A CA   1 
ATOM   3644 C  C    . ASP A 1 227 ? -21.91907 -19.16325 -11.90671 1.000 8.65078  ? 1686 ASP A C    1 
ATOM   3645 O  O    . ASP A 1 227 ? -23.00625 -18.63156 -11.73643 1.000 9.18767  ? 1686 ASP A O    1 
ATOM   3646 C  CB   . ASP A 1 227 ? -20.82716 -16.95093 -11.29061 1.000 8.54024  ? 1686 ASP A CB   1 
ATOM   3647 C  CG   . ASP A 1 227 ? -21.58769 -16.73829 -10.00650 1.000 9.56673  ? 1686 ASP A CG   1 
ATOM   3648 O  OD1  . ASP A 1 227 ? -21.58602 -17.65036 -9.11066  1.000 10.15357 ? 1686 ASP A OD1  1 
ATOM   3649 O  OD2  . ASP A 1 227 ? -22.14367 -15.62384 -9.86511  1.000 10.70102 ? 1686 ASP A OD2  1 
ATOM   3650 H  H    . ASP A 1 227 ? -18.85906 -18.97850 -12.41415 1.000 10.85464 ? 1686 ASP A H    1 
ATOM   3651 H  HA   . ASP A 1 227 ? -20.20988 -18.80220 -10.77813 1.000 9.62305  ? 1686 ASP A HA   1 
ATOM   3652 H  HB2  . ASP A 1 227 ? -19.96823 -16.50753 -11.20981 1.000 10.24828 ? 1686 ASP A HB2  1 
ATOM   3653 H  HB3  . ASP A 1 227 ? -21.33837 -16.55468 -12.01349 1.000 10.24828 ? 1686 ASP A HB3  1 
ATOM   3654 N  N    . HIS A 1 228 ? -21.80020 -20.44230 -12.30801 1.000 8.75614  ? 1687 HIS A N    1 
ATOM   3655 C  CA   . HIS A 1 228 ? -22.94460 -21.30538 -12.52149 1.000 10.16669 ? 1687 HIS A CA   1 
ATOM   3656 C  C    . HIS A 1 228 ? -23.77109 -21.27149 -11.24756 1.000 8.91402  ? 1687 HIS A C    1 
ATOM   3657 O  O    . HIS A 1 228 ? -23.33289 -21.73806 -10.18601 1.000 9.62719  ? 1687 HIS A O    1 
ATOM   3658 C  CB   . HIS A 1 228 ? -22.42204 -22.73983 -12.79252 1.000 9.80093  ? 1687 HIS A CB   1 
ATOM   3659 C  CG   . HIS A 1 228 ? -23.49511 -23.72542 -13.00589 1.000 9.68780  ? 1687 HIS A CG   1 
ATOM   3660 N  ND1  . HIS A 1 228 ? -24.11938 -23.87207 -14.22814 1.000 11.13262 ? 1687 HIS A ND1  1 
ATOM   3661 C  CD2  . HIS A 1 228 ? -24.01781 -24.63343 -12.16015 1.000 9.15878  ? 1687 HIS A CD2  1 
ATOM   3662 C  CE1  . HIS A 1 228 ? -24.98849 -24.86978 -14.11248 1.000 9.88253  ? 1687 HIS A CE1  1 
ATOM   3663 N  NE2  . HIS A 1 228 ? -24.96924 -25.31234 -12.86420 1.000 10.36672 ? 1687 HIS A NE2  1 
ATOM   3664 H  H    . HIS A 1 228 ? -21.04771 -20.82881 -12.46282 1.000 10.50737 ? 1687 HIS A H    1 
ATOM   3665 H  HA   . HIS A 1 228 ? -23.49111 -21.03081 -13.27437 1.000 12.20003 ? 1687 HIS A HA   1 
ATOM   3666 H  HB2  . HIS A 1 228 ? -21.86873 -22.72591 -13.58911 1.000 11.76111 ? 1687 HIS A HB2  1 
ATOM   3667 H  HB3  . HIS A 1 228 ? -21.89830 -23.03129 -12.02985 1.000 11.76111 ? 1687 HIS A HB3  1 
ATOM   3668 H  HD2  . HIS A 1 228 ? -23.77792 -24.77066 -11.27216 1.000 10.99054 ? 1687 HIS A HD2  1 
ATOM   3669 H  HE1  . HIS A 1 228 ? -25.52330 -25.20322 -14.79636 1.000 11.85904 ? 1687 HIS A HE1  1 
ATOM   3670 H  HE2  . HIS A 1 228 ? -25.47652 -25.93030 -12.54736 1.000 12.44007 ? 1687 HIS A HE2  1 
ATOM   3671 N  N    . ALA A 1 229 ? -25.00739 -20.74761 -11.33982 1.000 8.98506  ? 1688 ALA A N    1 
ATOM   3672 C  CA   . ALA A 1 229 ? -25.80228 -20.44480 -10.16236 1.000 9.51931  ? 1688 ALA A CA   1 
ATOM   3673 C  C    . ALA A 1 229 ? -27.22233 -20.87239 -10.47416 1.000 9.78514  ? 1688 ALA A C    1 
ATOM   3674 O  O    . ALA A 1 229 ? -28.12377 -20.04833 -10.72644 1.000 10.43521 ? 1688 ALA A O    1 
ATOM   3675 C  CB   . ALA A 1 229 ? -25.72198 -18.97013 -9.79815  1.000 9.57720  ? 1688 ALA A CB   1 
ATOM   3676 H  H    . ALA A 1 229 ? -25.39849 -20.56223 -12.08297 1.000 10.78207 ? 1688 ALA A H    1 
ATOM   3677 H  HA   . ALA A 1 229 ? -25.47770 -20.94193 -9.39528  1.000 11.42318 ? 1688 ALA A HA   1 
ATOM   3678 H  HB1  . ALA A 1 229 ? -26.27656 -18.80653 -9.01932  1.000 11.49264 ? 1688 ALA A HB1  1 
ATOM   3679 H  HB2  . ALA A 1 229 ? -24.79971 -18.74328 -9.60105  1.000 11.49264 ? 1688 ALA A HB2  1 
ATOM   3680 H  HB3  . ALA A 1 229 ? -26.03967 -18.44208 -10.54725 1.000 11.49264 ? 1688 ALA A HB3  1 
ATOM   3681 N  N    . PRO A 1 230 ? -27.47247 -22.17616 -10.45125 1.000 10.17463 ? 1689 PRO A N    1 
ATOM   3682 C  CA   . PRO A 1 230 ? -28.74304 -22.71605 -10.91180 1.000 9.78514  ? 1689 PRO A CA   1 
ATOM   3683 C  C    . PRO A 1 230 ? -29.81847 -22.50576 -9.87268  1.000 9.45357  ? 1689 PRO A C    1 
ATOM   3684 O  O    . PRO A 1 230 ? -29.63193 -22.71750 -8.68081  1.000 10.24570 ? 1689 PRO A O    1 
ATOM   3685 C  CB   . PRO A 1 230 ? -28.43758 -24.20370 -11.13259 1.000 10.75101 ? 1689 PRO A CB   1 
ATOM   3686 C  CG   . PRO A 1 230 ? -27.30300 -24.49650 -10.14633 1.000 10.38259 ? 1689 PRO A CG   1 
ATOM   3687 C  CD   . PRO A 1 230 ? -26.48927 -23.20928 -10.08842 1.000 10.28783 ? 1689 PRO A CD   1 
ATOM   3688 H  HA   . PRO A 1 230 ? -29.01873 -22.32355 -11.75491 1.000 11.74216 ? 1689 PRO A HA   1 
ATOM   3689 H  HB2  . PRO A 1 230 ? -29.22176 -24.73926 -10.93477 1.000 12.90121 ? 1689 PRO A HB2  1 
ATOM   3690 H  HB3  . PRO A 1 230 ? -28.15484 -24.35496 -12.04806 1.000 12.90121 ? 1689 PRO A HB3  1 
ATOM   3691 H  HG2  . PRO A 1 230 ? -27.67000 -24.71418 -9.27523  1.000 12.45911 ? 1689 PRO A HG2  1 
ATOM   3692 H  HG3  . PRO A 1 230 ? -26.76326 -25.23351 -10.47253 1.000 12.45911 ? 1689 PRO A HG3  1 
ATOM   3693 H  HD2  . PRO A 1 230 ? -26.14311 -23.05878 -9.19487  1.000 12.34540 ? 1689 PRO A HD2  1 
ATOM   3694 H  HD3  . PRO A 1 230 ? -25.75977 -23.23216 -10.72732 1.000 12.34540 ? 1689 PRO A HD3  1 
ATOM   3695 N  N    . HIS A 1 231 ? -31.00040 -22.18043 -10.39583 1.000 10.23776 ? 1690 HIS A N    1 
ATOM   3696 C  CA   . HIS A 1 231 ? -32.26744 -22.07560 -9.68731  1.000 10.72999 ? 1690 HIS A CA   1 
ATOM   3697 C  C    . HIS A 1 231 ? -33.30251 -22.52901 -10.71110 1.000 9.66151  ? 1690 HIS A C    1 
ATOM   3698 O  O    . HIS A 1 231 ? -33.09598 -22.36718 -11.91398 1.000 10.25358 ? 1690 HIS A O    1 
ATOM   3699 C  CB   . HIS A 1 231 ? -32.58465 -20.61602 -9.26656  1.000 10.54052 ? 1690 HIS A CB   1 
ATOM   3700 C  CG   . HIS A 1 231 ? -31.55312 -19.99567 -8.39525  1.000 11.15368 ? 1690 HIS A CG   1 
ATOM   3701 N  ND1  . HIS A 1 231 ? -31.41285 -20.31306 -7.05269  1.000 11.16691 ? 1690 HIS A ND1  1 
ATOM   3702 C  CD2  . HIS A 1 231 ? -30.64339 -19.02081 -8.66540  1.000 10.85110 ? 1690 HIS A CD2  1 
ATOM   3703 C  CE1  . HIS A 1 231 ? -30.43177 -19.57279 -6.55448  1.000 11.46688 ? 1690 HIS A CE1  1 
ATOM   3704 N  NE2  . HIS A 1 231 ? -29.96923 -18.77764 -7.51002  1.000 11.03789 ? 1690 HIS A NE2  1 
ATOM   3705 H  H    . HIS A 1 231 ? -31.09999 -22.00100 -11.23099 1.000 12.28532 ? 1690 HIS A H    1 
ATOM   3706 H  HA   . HIS A 1 231 ? -32.27524 -22.61544 -8.88145  1.000 12.87599 ? 1690 HIS A HA   1 
ATOM   3707 H  HB2  . HIS A 1 231 ? -32.66014 -20.07212 -10.06617 1.000 12.64862 ? 1690 HIS A HB2  1 
ATOM   3708 H  HB3  . HIS A 1 231 ? -33.42376 -20.60884 -8.78000  1.000 12.64862 ? 1690 HIS A HB3  1 
ATOM   3709 H  HD2  . HIS A 1 231 ? -30.50842 -18.60088 -9.48414  1.000 13.02132 ? 1690 HIS A HD2  1 
ATOM   3710 H  HE1  . HIS A 1 231 ? -30.11947 -19.60577 -5.67911  1.000 13.76026 ? 1690 HIS A HE1  1 
ATOM   3711 H  HE2  . HIS A 1 231 ? -29.34080 -18.19850 -7.41375  1.000 13.24547 ? 1690 HIS A HE2  1 
ATOM   3712 N  N    . THR A 1 232 ? -34.44327 -23.06806 -10.25686 1.000 10.51942 ? 1691 THR A N    1 
ATOM   3713 C  CA   . THR A 1 232 ? -35.44628 -23.51791 -11.21006 1.000 11.69328 ? 1691 THR A CA   1 
ATOM   3714 C  C    . THR A 1 232 ? -36.15946 -22.30846 -11.83142 1.000 11.31432 ? 1691 THR A C    1 
ATOM   3715 O  O    . THR A 1 232 ? -36.15711 -21.19991 -11.28922 1.000 12.60915 ? 1691 THR A O    1 
ATOM   3716 C  CB   . THR A 1 232 ? -36.45874 -24.45855 -10.54798 1.000 13.46455 ? 1691 THR A CB   1 
ATOM   3717 O  OG1  . THR A 1 232 ? -37.23792 -23.67639 -9.63629  1.000 13.70137 ? 1691 THR A OG1  1 
ATOM   3718 C  CG2  . THR A 1 232 ? -35.77890 -25.63574 -9.82272  1.000 14.78831 ? 1691 THR A CG2  1 
ATOM   3719 H  H    . THR A 1 232 ? -34.64654 -23.17743 -9.42841  1.000 12.62330 ? 1691 THR A H    1 
ATOM   3720 H  HA   . THR A 1 232 ? -35.01597 -24.01938 -11.92017 1.000 14.03194 ? 1691 THR A HA   1 
ATOM   3721 H  HB   . THR A 1 232 ? -37.02800 -24.86640 -11.21918 1.000 16.15746 ? 1691 THR A HB   1 
ATOM   3722 H  HG1  . THR A 1 232 ? -36.73874 -23.32757 -9.05773  1.000 16.44164 ? 1691 THR A HG1  1 
ATOM   3723 H  HG21 . THR A 1 232 ? -36.45049 -26.23255 -9.45709  1.000 17.74597 ? 1691 THR A HG21 1 
ATOM   3724 H  HG22 . THR A 1 232 ? -35.22217 -26.13103 -10.44371 1.000 17.74597 ? 1691 THR A HG22 1 
ATOM   3725 H  HG23 . THR A 1 232 ? -35.22490 -25.30406 -9.09887  1.000 17.74597 ? 1691 THR A HG23 1 
ATOM   3726 N  N    . LEU A 1 233 ? -36.82672 -22.54467 -12.96315 1.000 12.02750 ? 1692 LEU A N    1 
ATOM   3727 C  CA   . LEU A 1 233 ? -37.59527 -21.49968 -13.59818 1.000 12.69601 ? 1692 LEU A CA   1 
ATOM   3728 C  C    . LEU A 1 233 ? -38.70541 -21.00912 -12.66664 1.000 12.63287 ? 1692 LEU A C    1 
ATOM   3729 O  O    . LEU A 1 233 ? -38.95018 -19.80436 -12.58722 1.000 13.27505 ? 1692 LEU A O    1 
ATOM   3730 C  CB   . LEU A 1 233 ? -38.21337 -21.98573 -14.89947 1.000 13.64872 ? 1692 LEU A CB   1 
ATOM   3731 C  CG   . LEU A 1 233 ? -38.96274 -20.92271 -15.69840 1.000 14.12254 ? 1692 LEU A CG   1 
ATOM   3732 C  CD1  . LEU A 1 233 ? -37.97817 -19.86068 -16.23073 1.000 15.50157 ? 1692 LEU A CD1  1 
ATOM   3733 C  CD2  . LEU A 1 233 ? -39.68212 -21.54658 -16.83289 1.000 15.14101 ? 1692 LEU A CD2  1 
ATOM   3734 H  H    . LEU A 1 233 ? -36.84501 -23.29985 -13.37421 1.000 14.43300 ? 1692 LEU A H    1 
ATOM   3735 H  HA   . LEU A 1 233 ? -36.99320 -20.76844 -13.80722 1.000 15.23521 ? 1692 LEU A HA   1 
ATOM   3736 H  HB2  . LEU A 1 233 ? -37.50419 -22.32879 -15.46541 1.000 16.37846 ? 1692 LEU A HB2  1 
ATOM   3737 H  HB3  . LEU A 1 233 ? -38.84434 -22.69290 -14.69286 1.000 16.37846 ? 1692 LEU A HB3  1 
ATOM   3738 H  HG   . LEU A 1 233 ? -39.60805 -20.48835 -15.11891 1.000 16.94705 ? 1692 LEU A HG   1 
ATOM   3739 H  HD11 . LEU A 1 233 ? -38.45369 -19.25850 -16.82416 1.000 18.60188 ? 1692 LEU A HD11 1 
ATOM   3740 H  HD12 . LEU A 1 233 ? -37.61196 -19.36569 -15.48122 1.000 18.60188 ? 1692 LEU A HD12 1 
ATOM   3741 H  HD13 . LEU A 1 233 ? -37.26433 -20.30574 -16.71368 1.000 18.60188 ? 1692 LEU A HD13 1 
ATOM   3742 H  HD21 . LEU A 1 233 ? -40.15819 -20.85752 -17.32223 1.000 18.16922 ? 1692 LEU A HD21 1 
ATOM   3743 H  HD22 . LEU A 1 233 ? -39.03857 -21.98065 -17.41455 1.000 18.16922 ? 1692 LEU A HD22 1 
ATOM   3744 H  HD23 . LEU A 1 233 ? -40.30972 -22.20061 -16.48757 1.000 18.16922 ? 1692 LEU A HD23 1 
ATOM   3745 N  N    . GLU A 1 234 ? -39.36308 -21.92279 -11.94392 1.000 13.05399 ? 1693 GLU A N    1 
ATOM   3746 C  CA   . GLU A 1 234 ? -40.38846 -21.50232 -11.01028 1.000 13.73564 ? 1693 GLU A CA   1 
ATOM   3747 C  C    . GLU A 1 234 ? -39.82086 -20.53997 -9.98911  1.000 12.79605 ? 1693 GLU A C    1 
ATOM   3748 O  O    . GLU A 1 234 ? -40.46968 -19.55541 -9.61953  1.000 13.32238 ? 1693 GLU A O    1 
ATOM   3749 C  CB   . GLU A 1 234 ? -40.96973 -22.73887 -10.30250 1.000 15.27008 ? 1693 GLU A CB   1 
ATOM   3750 C  CG   . GLU A 1 234 ? -42.11195 -22.46017 -9.28312  1.000 18.65196 ? 1693 GLU A CG   1 
ATOM   3751 C  CD   . GLU A 1 234 ? -41.60507 -22.14882 -7.85586  1.000 22.14190 ? 1693 GLU A CD   1 
ATOM   3752 O  OE1  . GLU A 1 234 ? -40.59280 -22.76596 -7.40351  1.000 24.04202 ? 1693 GLU A OE1  1 
ATOM   3753 O  OE2  . GLU A 1 234 ? -42.21426 -21.30435 -7.16864  1.000 24.63419 ? 1693 GLU A OE2  1 
ATOM   3754 H  H    . GLU A 1 234 ? -39.23150 -22.77188 -11.98046 1.000 15.66479 ? 1693 GLU A H    1 
ATOM   3755 H  HA   . GLU A 1 234 ? -41.10096 -21.05456 -11.49274 1.000 16.48277 ? 1693 GLU A HA   1 
ATOM   3756 H  HB2  . GLU A 1 234 ? -41.32685 -23.33609 -10.97829 1.000 18.32410 ? 1693 GLU A HB2  1 
ATOM   3757 H  HB3  . GLU A 1 234 ? -40.25259 -23.17699 -9.81808  1.000 18.32410 ? 1693 GLU A HB3  1 
ATOM   3758 H  HG2  . GLU A 1 234 ? -42.62464 -21.69563 -9.58895  1.000 22.38236 ? 1693 GLU A HG2  1 
ATOM   3759 H  HG3  . GLU A 1 234 ? -42.68257 -23.24283 -9.23086  1.000 22.38236 ? 1693 GLU A HG3  1 
ATOM   3760 N  N    . GLU A 1 235 ? -38.60415 -20.80224 -9.49820  1.000 12.29071 ? 1694 GLU A N    1 
ATOM   3761 C  CA   . GLU A 1 235 ? -38.02624 -19.90575 -8.50823  1.000 12.03012 ? 1694 GLU A CA   1 
ATOM   3762 C  C    . GLU A 1 235 ? -37.65470 -18.55364 -9.12835  1.000 11.45906 ? 1694 GLU A C    1 
ATOM   3763 O  O    . GLU A 1 235 ? -37.93503 -17.47543 -8.55220  1.000 12.44333 ? 1694 GLU A O    1 
ATOM   3764 C  CB   . GLU A 1 235 ? -36.78478 -20.55216 -7.89043  1.000 11.82232 ? 1694 GLU A CB   1 
ATOM   3765 C  CG   . GLU A 1 235 ? -37.11628 -21.74308 -6.96762  1.000 12.91443 ? 1694 GLU A CG   1 
ATOM   3766 C  CD   . GLU A 1 235 ? -35.89177 -22.53482 -6.54588  1.000 13.25133 ? 1694 GLU A CD   1 
ATOM   3767 O  OE1  . GLU A 1 235 ? -34.90732 -22.63740 -7.33401  1.000 12.76184 ? 1694 GLU A OE1  1 
ATOM   3768 O  OE2  . GLU A 1 235 ? -35.95054 -23.09932 -5.41639  1.000 14.61461 ? 1694 GLU A OE2  1 
ATOM   3769 H  H    . GLU A 1 235 ? -38.11234 -21.47260 -9.71806  1.000 14.74885 ? 1694 GLU A H    1 
ATOM   3770 H  HA   . GLU A 1 235 ? -38.68044 -19.75131 -7.80889  1.000 14.43614 ? 1694 GLU A HA   1 
ATOM   3771 H  HB2  . GLU A 1 235 ? -36.21215 -20.87676 -8.60291  1.000 14.18679 ? 1694 GLU A HB2  1 
ATOM   3772 H  HB3  . GLU A 1 235 ? -36.31413 -19.88776 -7.36320  1.000 14.18679 ? 1694 GLU A HB3  1 
ATOM   3773 H  HG2  . GLU A 1 235 ? -37.54528 -21.40823 -6.16466  1.000 15.49731 ? 1694 GLU A HG2  1 
ATOM   3774 H  HG3  . GLU A 1 235 ? -37.71403 -22.34648 -7.43612  1.000 15.49731 ? 1694 GLU A HG3  1 
ATOM   3775 N  N    . LYS A 1 236 ? -37.07316 -18.58517 -10.32747 1.000 12.00380 ? 1695 LYS A N    1 
ATOM   3776 C  CA   . LYS A 1 236 ? -36.67556 -17.34277 -11.00056 1.000 10.69846 ? 1695 LYS A CA   1 
ATOM   3777 C  C    . LYS A 1 236 ? -37.85653 -16.46778 -11.35359 1.000 12.39338 ? 1695 LYS A C    1 
ATOM   3778 O  O    . LYS A 1 236 ? -37.70673 -15.24073 -11.42558 1.000 13.46188 ? 1695 LYS A O    1 
ATOM   3779 C  CB   . LYS A 1 236 ? -35.95613 -17.66594 -12.29847 1.000 10.44579 ? 1695 LYS A CB   1 
ATOM   3780 C  CG   . LYS A 1 236 ? -34.59831 -18.33814 -12.18529 1.000 11.69586 ? 1695 LYS A CG   1 
ATOM   3781 C  CD   . LYS A 1 236 ? -33.54411 -17.54924 -11.40714 1.000 11.86169 ? 1695 LYS A CD   1 
ATOM   3782 C  CE   . LYS A 1 236 ? -33.26168 -16.18484 -11.97819 1.000 10.98794 ? 1695 LYS A CE   1 
ATOM   3783 N  NZ   . LYS A 1 236 ? -32.08522 -15.56070 -11.34945 1.000 10.93789 ? 1695 LYS A NZ   1 
ATOM   3784 H  H    . LYS A 1 236 ? -36.89832 -19.30151 -10.77005 1.000 14.40456 ? 1695 LYS A H    1 
ATOM   3785 H  HA   . LYS A 1 236 ? -36.09048 -16.86436 -10.39253 1.000 12.83816 ? 1695 LYS A HA   1 
ATOM   3786 H  HB2  . LYS A 1 236 ? -36.52299 -18.26004 -12.81484 1.000 12.53494 ? 1695 LYS A HB2  1 
ATOM   3787 H  HB3  . LYS A 1 236 ? -35.82042 -16.83504 -12.78022 1.000 12.53494 ? 1695 LYS A HB3  1 
ATOM   3788 H  HG2  . LYS A 1 236 ? -34.71359 -19.18922 -11.73443 1.000 14.03503 ? 1695 LYS A HG2  1 
ATOM   3789 H  HG3  . LYS A 1 236 ? -34.25078 -18.48086 -13.07958 1.000 14.03503 ? 1695 LYS A HG3  1 
ATOM   3790 H  HD2  . LYS A 1 236 ? -33.85337 -17.42933 -10.49562 1.000 14.23403 ? 1695 LYS A HD2  1 
ATOM   3791 H  HD3  . LYS A 1 236 ? -32.71285 -18.04912 -11.41239 1.000 14.23403 ? 1695 LYS A HD3  1 
ATOM   3792 H  HE2  . LYS A 1 236 ? -33.09055 -16.26545 -12.92956 1.000 13.18553 ? 1695 LYS A HE2  1 
ATOM   3793 H  HE3  . LYS A 1 236 ? -34.02794 -15.60975 -11.82649 1.000 13.18553 ? 1695 LYS A HE3  1 
ATOM   3794 H  HZ1  . LYS A 1 236 ? -31.36350 -16.06252 -11.48872 1.000 13.12547 ? 1695 LYS A HZ1  1 
ATOM   3795 H  HZ2  . LYS A 1 236 ? -32.21576 -15.47947 -10.47283 1.000 13.12547 ? 1695 LYS A HZ2  1 
ATOM   3796 H  HZ3  . LYS A 1 236 ? -31.94692 -14.75309 -11.69693 1.000 13.12547 ? 1695 LYS A HZ3  1 
ATOM   3797 N  N    . CYS A 1 237 ? -39.02444 -17.06061 -11.59027 1.000 12.77505 ? 1696 CYS A N    1 
ATOM   3798 C  CA   . CYS A 1 237 ? -40.20276 -16.29904 -11.98098 1.000 14.48841 ? 1696 CYS A CA   1 
ATOM   3799 C  C    . CYS A 1 237 ? -41.26734 -16.16488 -10.91475 1.000 13.68050 ? 1696 CYS A C    1 
ATOM   3800 O  O    . CYS A 1 237 ? -42.36103 -15.66284 -11.20071 1.000 15.20680 ? 1696 CYS A O    1 
ATOM   3801 C  CB   . CYS A 1 237 ? -40.80270 -16.88919 -13.25291 1.000 17.52028 ? 1696 CYS A CB   1 
ATOM   3802 S  SG   . CYS A 1 237 ? -39.65388 -17.06099 -14.60265 1.000 21.61255 ? 1696 CYS A SG   1 
ATOM   3803 H  H    . CYS A 1 237 ? -39.15768 -17.90810 -11.53014 1.000 15.33006 ? 1696 CYS A H    1 
ATOM   3804 H  HA   . CYS A 1 237 ? -39.90345 -15.39434 -12.16212 1.000 17.38609 ? 1696 CYS A HA   1 
ATOM   3805 H  HB2  . CYS A 1 237 ? -41.14977 -17.77188 -13.04967 1.000 21.02434 ? 1696 CYS A HB2  1 
ATOM   3806 H  HB3  . CYS A 1 237 ? -41.52164 -16.31084 -13.55215 1.000 21.02434 ? 1696 CYS A HB3  1 
ATOM   3807 H  HG   . CYS A 1 237 ? -40.21369 -17.58005 -15.52850 1.000 25.93506 ? 1696 CYS A HG   1 
ATOM   3808 N  N    . GLY A 1 238 ? -40.97272 -16.53062 -9.70314  1.000 13.85675 ? 1697 GLY A N    1 
ATOM   3809 C  CA   . GLY A 1 238 ? -41.89889 -16.46660 -8.59216  1.000 15.68845 ? 1697 GLY A CA   1 
ATOM   3810 C  C    . GLY A 1 238 ? -41.81924 -15.17084 -7.83907  1.000 16.65446 ? 1697 GLY A C    1 
ATOM   3811 O  O    . GLY A 1 238 ? -41.28283 -14.17415 -8.32807  1.000 18.66249 ? 1697 GLY A O    1 
ATOM   3812 H  H    . GLY A 1 238 ? -40.20217 -16.83790 -9.47635  1.000 16.62810 ? 1697 GLY A H    1 
ATOM   3813 H  HA2  . GLY A 1 238 ? -42.80415 -16.56887 -8.92522  1.000 18.82614 ? 1697 GLY A HA2  1 
ATOM   3814 H  HA3  . GLY A 1 238 ? -41.70624 -17.18906 -7.97422  1.000 18.82614 ? 1697 GLY A HA3  1 
ATOM   3815 N  N    . SER A 1 239 ? -42.35906 -15.18967 -6.60437  1.000 18.31255 ? 1698 SER A N    1 
ATOM   3816 C  CA   . SER A 1 239 ? -42.55371 -13.95271 -5.88917  1.000 21.85503 ? 1698 SER A CA   1 
ATOM   3817 C  C    . SER A 1 239 ? -41.29422 -13.36052 -5.29429  1.000 22.87618 ? 1698 SER A C    1 
ATOM   3818 O  O    . SER A 1 239 ? -41.30780 -12.17093 -4.96224  1.000 27.20026 ? 1698 SER A O    1 
ATOM   3819 C  CB   . SER A 1 239 ? -43.57881 -14.12068 -4.75696  1.000 24.71590 ? 1698 SER A CB   1 
ATOM   3820 O  OG   . SER A 1 239 ? -43.11590 -15.07898 -3.82686  1.000 28.55304 ? 1698 SER A OG   1 
ATOM   3821 H  H    . SER A 1 239 ? -42.60903 -15.89727 -6.18434  1.000 21.97506 ? 1698 SER A H    1 
ATOM   3822 H  HA   . SER A 1 239 ? -42.90083 -13.32259 -6.53984  1.000 26.22603 ? 1698 SER A HA   1 
ATOM   3823 H  HB2  . SER A 1 239 ? -43.69926 -13.27023 -4.30627  1.000 29.65908 ? 1698 SER A HB2  1 
ATOM   3824 H  HB3  . SER A 1 239 ? -44.42208 -14.42013 -5.13130  1.000 29.65908 ? 1698 SER A HB3  1 
ATOM   3825 H  HG   . SER A 1 239 ? -43.67683 -15.17384 -3.20883  1.000 34.26365 ? 1698 SER A HG   1 
ATOM   3826 N  N    . ARG A 1 240 ? -40.20159 -14.11933 -5.15492  1.000 19.76009 ? 1699 ARG A N    1 
ATOM   3827 C  CA   . ARG A 1 240 ? -38.95038 -13.57737 -4.61040  1.000 21.32593 ? 1699 ARG A CA   1 
ATOM   3828 C  C    . ARG A 1 240 ? -37.80114 -14.19326 -5.38120  1.000 19.35475 ? 1699 ARG A C    1 
ATOM   3829 O  O    . ARG A 1 240 ? -37.11474 -15.10167 -4.89404  1.000 21.02852 ? 1699 ARG A O    1 
ATOM   3830 C  CB   . ARG A 1 240 ? -38.83941 -13.87628 -3.11113  1.000 23.52879 ? 1699 ARG A CB   1 
ATOM   3831 H  H    . ARG A 1 240 ? -40.16058 -14.95128 -5.36889  1.000 23.71211 ? 1699 ARG A H    1 
ATOM   3832 H  HA   . ARG A 1 240 ? -38.92674 -12.61494 -4.72900  1.000 25.59112 ? 1699 ARG A HA   1 
ATOM   3833 N  N    . PRO A 1 241 ? -37.59161 -13.76554 -6.61424  1.000 17.91255 ? 1700 PRO A N    1 
ATOM   3834 C  CA   . PRO A 1 241 ? -36.62261 -14.48308 -7.48272  1.000 16.72028 ? 1700 PRO A CA   1 
ATOM   3835 C  C    . PRO A 1 241 ? -35.22305 -14.43256 -6.87382  1.000 15.75427 ? 1700 PRO A C    1 
ATOM   3836 O  O    . PRO A 1 241 ? -34.69911 -13.36036 -6.53599  1.000 17.09126 ? 1700 PRO A O    1 
ATOM   3837 C  CB   . PRO A 1 241 ? -36.71019 -13.67495 -8.77656  1.000 17.68090 ? 1700 PRO A CB   1 
ATOM   3838 C  CG   . PRO A 1 241 ? -38.21717 -13.20944 -8.76523  1.000 21.83376 ? 1700 PRO A CG   1 
ATOM   3839 C  CD   . PRO A 1 241 ? -38.26661 -12.67286 -7.35938  1.000 20.71273 ? 1700 PRO A CD   1 
ATOM   3840 H  HA   . PRO A 1 241 ? -36.87309 -15.40659 -7.64178  1.000 20.06434 ? 1700 PRO A HA   1 
ATOM   3841 H  HB2  . PRO A 1 241 ? -36.10149 -12.92013 -8.75128  1.000 21.21708 ? 1700 PRO A HB2  1 
ATOM   3842 H  HB3  . PRO A 1 241 ? -36.51338 -14.23428 -9.54422  1.000 21.21708 ? 1700 PRO A HB3  1 
ATOM   3843 H  HG2  . PRO A 1 241 ? -38.38420 -12.52327 -9.43018  1.000 26.20051 ? 1700 PRO A HG2  1 
ATOM   3844 H  HG3  . PRO A 1 241 ? -38.82259 -13.95541 -8.89898  1.000 26.20051 ? 1700 PRO A HG3  1 
ATOM   3845 H  HD2  . PRO A 1 241 ? -37.77881 -11.83802 -7.28200  1.000 24.85528 ? 1700 PRO A HD2  1 
ATOM   3846 H  HD3  . PRO A 1 241 ? -39.18091 -12.55196 -7.05881  1.000 24.85528 ? 1700 PRO A HD3  1 
ATOM   3847 N  N    . PRO A 1 242 ? -34.55926 -15.57359 -6.75740  1.000 13.17509 ? 1701 PRO A N    1 
ATOM   3848 C  CA   . PRO A 1 242 ? -33.15666 -15.58684 -6.31171  1.000 12.15649 ? 1701 PRO A CA   1 
ATOM   3849 C  C    . PRO A 1 242 ? -32.27404 -15.16187 -7.46083  1.000 11.26702 ? 1701 PRO A C    1 
ATOM   3850 O  O    . PRO A 1 242 ? -32.60989 -15.40373 -8.63725  1.000 11.91956 ? 1701 PRO A O    1 
ATOM   3851 C  CB   . PRO A 1 242 ? -32.90240 -17.04870 -5.94995  1.000 13.55664 ? 1701 PRO A CB   1 
ATOM   3852 C  CG   . PRO A 1 242 ? -33.88918 -17.79582 -6.76141  1.000 15.14622 ? 1701 PRO A CG   1 
ATOM   3853 C  CD   . PRO A 1 242 ? -35.09098 -16.92887 -6.95525  1.000 13.75409 ? 1701 PRO A CD   1 
ATOM   3854 H  HA   . PRO A 1 242 ? -33.01920 -15.03162 -5.52830  1.000 14.58779 ? 1701 PRO A HA   1 
ATOM   3855 H  HB2  . PRO A 1 242 ? -31.99481 -17.29794 -6.18456  1.000 16.26797 ? 1701 PRO A HB2  1 
ATOM   3856 H  HB3  . PRO A 1 242 ? -33.05029 -17.18876 -5.00157  1.000 16.26797 ? 1701 PRO A HB3  1 
ATOM   3857 H  HG2  . PRO A 1 242 ? -33.49312 -18.01503 -7.61931  1.000 18.17547 ? 1701 PRO A HG2  1 
ATOM   3858 H  HG3  . PRO A 1 242 ? -34.13519 -18.60838 -6.29224  1.000 18.17547 ? 1701 PRO A HG3  1 
ATOM   3859 H  HD2  . PRO A 1 242 ? -35.45129 -17.03197 -7.84992  1.000 16.50490 ? 1701 PRO A HD2  1 
ATOM   3860 H  HD3  . PRO A 1 242 ? -35.77395 -17.13206 -6.29709  1.000 16.50490 ? 1701 PRO A HD3  1 
ATOM   3861 N  N    . PRO A 1 243 ? -31.14421 -14.52455 -7.17379  1.000 11.62226 ? 1702 PRO A N    1 
ATOM   3862 C  CA   . PRO A 1 243 ? -30.23385 -14.10978 -8.24883  1.000 11.21957 ? 1702 PRO A CA   1 
ATOM   3863 C  C    . PRO A 1 243 ? -29.38248 -15.27957 -8.73337  1.000 9.94571  ? 1702 PRO A C    1 
ATOM   3864 O  O    . PRO A 1 243 ? -29.00183 -16.15435 -7.93524  1.000 11.74849 ? 1702 PRO A O    1 
ATOM   3865 C  CB   . PRO A 1 243 ? -29.36017 -13.07505 -7.55564  1.000 12.74338 ? 1702 PRO A CB   1 
ATOM   3866 C  CG   . PRO A 1 243 ? -29.27220 -13.59758 -6.14783  1.000 13.85137 ? 1702 PRO A CG   1 
ATOM   3867 C  CD   . PRO A 1 243 ? -30.64851 -14.18155 -5.84736  1.000 13.95391 ? 1702 PRO A CD   1 
ATOM   3868 H  HA   . PRO A 1 243 ? -30.71309 -13.71100 -8.99194  1.000 13.46349 ? 1702 PRO A HA   1 
ATOM   3869 H  HB2  . PRO A 1 243 ? -28.48609 -13.03496 -7.97430  1.000 15.29205 ? 1702 PRO A HB2  1 
ATOM   3870 H  HB3  . PRO A 1 243 ? -29.78205 -12.20206 -7.58417  1.000 15.29205 ? 1702 PRO A HB3  1 
ATOM   3871 H  HG2  . PRO A 1 243 ? -28.58709 -14.28206 -6.09293  1.000 16.62165 ? 1702 PRO A HG2  1 
ATOM   3872 H  HG3  . PRO A 1 243 ? -29.06490 -12.87114 -5.53938  1.000 16.62165 ? 1702 PRO A HG3  1 
ATOM   3873 H  HD2  . PRO A 1 243 ? -30.57705 -14.97068 -5.28784  1.000 16.74470 ? 1702 PRO A HD2  1 
ATOM   3874 H  HD3  . PRO A 1 243 ? -31.22023 -13.52367 -5.42165  1.000 16.74470 ? 1702 PRO A HD3  1 
ATOM   3875 N  N    . GLY A 1 244 ? -29.09521 -15.28391 -10.03522 1.000 9.56409  ? 1703 GLY A N    1 
ATOM   3876 C  CA   . GLY A 1 244 ? -28.12258 -16.22987 -10.57874 1.000 9.55353  ? 1703 GLY A CA   1 
ATOM   3877 C  C    . GLY A 1 244 ? -28.58081 -16.87276 -11.85960 1.000 9.42466  ? 1703 GLY A C    1 
ATOM   3878 O  O    . GLY A 1 244 ? -29.78125 -17.07142 -12.07557 1.000 10.59306 ? 1703 GLY A O    1 
ATOM   3879 H  H    . GLY A 1 244 ? -29.44651 -14.75513 -10.61537 1.000 11.47691 ? 1703 GLY A H    1 
ATOM   3880 H  HA2  . GLY A 1 244 ? -27.28936 -15.76535 -10.75441 1.000 11.46424 ? 1703 GLY A HA2  1 
ATOM   3881 H  HA3  . GLY A 1 244 ? -27.96197 -16.93149 -9.92847  1.000 11.46424 ? 1703 GLY A HA3  1 
ATOM   3882 N  N    . PHE A 1 245 ? -27.60338 -17.21639 -12.72416 1.000 10.02201 ? 1704 PHE A N    1 
ATOM   3883 C  CA   . PHE A 1 245 ? -27.80021 -17.91736 -13.96205 1.000 9.90615  ? 1704 PHE A CA   1 
ATOM   3884 C  C    . PHE A 1 245 ? -27.06776 -19.23153 -13.96385 1.000 9.89570  ? 1704 PHE A C    1 
ATOM   3885 O  O    . PHE A 1 245 ? -25.89549 -19.25687 -13.57966 1.000 9.79830  ? 1704 PHE A O    1 
ATOM   3886 C  CB   . PHE A 1 245 ? -27.22549 -17.12738 -15.12322 1.000 10.49308 ? 1704 PHE A CB   1 
ATOM   3887 C  CG   . PHE A 1 245 ? -27.76810 -15.70945 -15.27969 1.000 9.77206  ? 1704 PHE A CG   1 
ATOM   3888 C  CD1  . PHE A 1 245 ? -29.06683 -15.34593 -14.92939 1.000 11.11163 ? 1704 PHE A CD1  1 
ATOM   3889 C  CD2  . PHE A 1 245 ? -26.96861 -14.75756 -15.90624 1.000 11.15636 ? 1704 PHE A CD2  1 
ATOM   3890 C  CE1  . PHE A 1 245 ? -29.55707 -14.04907 -15.16414 1.000 12.16955 ? 1704 PHE A CE1  1 
ATOM   3891 C  CE2  . PHE A 1 245 ? -27.44553 -13.47876 -16.11598 1.000 12.59338 ? 1704 PHE A CE2  1 
ATOM   3892 C  CZ   . PHE A 1 245 ? -28.75501 -13.11505 -15.74859 1.000 12.85390 ? 1704 PHE A CZ   1 
ATOM   3893 H  H    . PHE A 1 245 ? -26.77421 -17.03345 -12.58775 1.000 12.02642 ? 1704 PHE A H    1 
ATOM   3894 H  HA   . PHE A 1 245 ? -28.75272 -18.06188 -14.07494 1.000 11.88738 ? 1704 PHE A HA   1 
ATOM   3895 H  HB2  . PHE A 1 245 ? -26.26574 -17.05812 -15.00079 1.000 12.59170 ? 1704 PHE A HB2  1 
ATOM   3896 H  HB3  . PHE A 1 245 ? -27.42157 -17.60458 -15.94464 1.000 12.59170 ? 1704 PHE A HB3  1 
ATOM   3897 H  HD1  . PHE A 1 245 ? -29.62268 -15.97606 -14.53081 1.000 13.33395 ? 1704 PHE A HD1  1 
ATOM   3898 H  HD2  . PHE A 1 245 ? -26.11048 -14.98363 -16.18448 1.000 13.38763 ? 1704 PHE A HD2  1 
ATOM   3899 H  HE1  . PHE A 1 245 ? -30.42733 -13.82907 -14.92093 1.000 14.60346 ? 1704 PHE A HE1  1 
ATOM   3900 H  HE2  . PHE A 1 245 ? -26.88999 -12.84438 -16.50820 1.000 15.11206 ? 1704 PHE A HE2  1 
ATOM   3901 H  HZ   . PHE A 1 245 ? -29.06721 -12.25256 -15.90204 1.000 15.42469 ? 1704 PHE A HZ   1 
ATOM   3902 N  N    . PRO A 1 246 ? -27.62645 -20.29978 -14.54070 1.000 9.78783  ? 1705 PRO A N    1 
ATOM   3903 C  CA   . PRO A 1 246 ? -26.79681 -21.46604 -14.88388 1.000 10.17734 ? 1705 PRO A CA   1 
ATOM   3904 C  C    . PRO A 1 246 ? -25.91118 -21.08981 -16.05308 1.000 10.22732 ? 1705 PRO A C    1 
ATOM   3905 O  O    . PRO A 1 246 ? -26.24047 -20.21516 -16.84870 1.000 10.70100 ? 1705 PRO A O    1 
ATOM   3906 C  CB   . PRO A 1 246 ? -27.86245 -22.49729 -15.32498 1.000 11.42479 ? 1705 PRO A CB   1 
ATOM   3907 C  CG   . PRO A 1 246 ? -28.94113 -21.65942 -15.92408 1.000 12.54857 ? 1705 PRO A CG   1 
ATOM   3908 C  CD   . PRO A 1 246 ? -28.99674 -20.39362 -15.11082 1.000 11.82743 ? 1705 PRO A CD   1 
ATOM   3909 H  HA   . PRO A 1 246 ? -26.28117 -21.81172 -14.13854 1.000 12.21281 ? 1705 PRO A HA   1 
ATOM   3910 H  HB2  . PRO A 1 246 ? -27.48743 -23.10781 -15.97884 1.000 13.70975 ? 1705 PRO A HB2  1 
ATOM   3911 H  HB3  . PRO A 1 246 ? -28.18760 -22.99251 -14.55691 1.000 13.70975 ? 1705 PRO A HB3  1 
ATOM   3912 H  HG2  . PRO A 1 246 ? -28.72379 -21.46217 -16.84861 1.000 15.05828 ? 1705 PRO A HG2  1 
ATOM   3913 H  HG3  . PRO A 1 246 ? -29.78581 -22.13384 -15.87579 1.000 15.05828 ? 1705 PRO A HG3  1 
ATOM   3914 H  HD2  . PRO A 1 246 ? -29.19021 -19.62830 -15.67451 1.000 14.19291 ? 1705 PRO A HD2  1 
ATOM   3915 H  HD3  . PRO A 1 246 ? -29.66044 -20.46340 -14.40687 1.000 14.19291 ? 1705 PRO A HD3  1 
ATOM   3916 N  N    . GLY A 1 247 ? -24.74641 -21.72745 -16.13453 1.000 9.57986  ? 1706 GLY A N    1 
ATOM   3917 C  CA   . GLY A 1 247 ? -23.78350 -21.30668 -17.15453 1.000 9.76144  ? 1706 GLY A CA   1 
ATOM   3918 C  C    . GLY A 1 247 ? -22.71783 -22.31249 -17.56763 1.000 10.11152 ? 1706 GLY A C    1 
ATOM   3919 O  O    . GLY A 1 247 ? -21.99683 -22.00711 -18.50855 1.000 10.00095 ? 1706 GLY A O    1 
ATOM   3920 H  H    . GLY A 1 247 ? -24.49795 -22.38012 -15.63264 1.000 11.49583 ? 1706 GLY A H    1 
ATOM   3921 H  HA2  . GLY A 1 247 ? -24.27700 -21.07022 -17.95544 1.000 11.71373 ? 1706 GLY A HA2  1 
ATOM   3922 H  HA3  . GLY A 1 247 ? -23.32020 -20.52057 -16.82545 1.000 11.71373 ? 1706 GLY A HA3  1 
ATOM   3923 N  N    . LEU A 1 248 ? -22.62360 -23.48280 -16.91529 1.000 9.69567  ? 1707 LEU A N    1 
ATOM   3924 C  CA   . LEU A 1 248 ? -21.58527 -24.43093 -17.31860 1.000 10.00092 ? 1707 LEU A CA   1 
ATOM   3925 C  C    . LEU A 1 248 ? -21.73208 -24.87519 -18.75691 1.000 10.10368 ? 1707 LEU A C    1 
ATOM   3926 O  O    . LEU A 1 248 ? -20.74535 -25.02634 -19.46832 1.000 10.65889 ? 1707 LEU A O    1 
ATOM   3927 C  CB   . LEU A 1 248 ? -21.57434 -25.63047 -16.37880 1.000 9.95096  ? 1707 LEU A CB   1 
ATOM   3928 C  CG   . LEU A 1 248 ? -20.85857 -25.38692 -15.05842 1.000 10.59843 ? 1707 LEU A CG   1 
ATOM   3929 C  CD1  . LEU A 1 248 ? -21.24800 -26.39319 -14.01395 1.000 10.82473 ? 1707 LEU A CD1  1 
ATOM   3930 C  CD2  . LEU A 1 248 ? -19.30941 -25.35919 -15.28095 1.000 11.73005 ? 1707 LEU A CD2  1 
ATOM   3931 H  H    . LEU A 1 248 ? -23.12741 -23.73648 -16.26612 1.000 11.63480 ? 1707 LEU A H    1 
ATOM   3932 H  HA   . LEU A 1 248 ? -20.72832 -23.98206 -17.24760 1.000 12.00110 ? 1707 LEU A HA   1 
ATOM   3933 H  HB2  . LEU A 1 248 ? -22.49158 -25.87223 -16.17599 1.000 11.94115 ? 1707 LEU A HB2  1 
ATOM   3934 H  HB3  . LEU A 1 248 ? -21.12768 -26.36749 -16.82400 1.000 11.94115 ? 1707 LEU A HB3  1 
ATOM   3935 H  HG   . LEU A 1 248 ? -21.12984 -24.52138 -14.71469 1.000 12.71811 ? 1707 LEU A HG   1 
ATOM   3936 H  HD11 . LEU A 1 248 ? -20.76941 -26.19776 -13.19318 1.000 12.98968 ? 1707 LEU A HD11 1 
ATOM   3937 H  HD12 . LEU A 1 248 ? -22.20414 -26.33573 -13.86103 1.000 12.98968 ? 1707 LEU A HD12 1 
ATOM   3938 H  HD13 . LEU A 1 248 ? -21.01611 -27.28092 -14.32870 1.000 12.98968 ? 1707 LEU A HD13 1 
ATOM   3939 H  HD21 . LEU A 1 248 ? -18.86755 -25.30299 -14.41927 1.000 14.07606 ? 1707 LEU A HD21 1 
ATOM   3940 H  HD22 . LEU A 1 248 ? -19.04139 -26.17185 -15.73774 1.000 14.07606 ? 1707 LEU A HD22 1 
ATOM   3941 H  HD23 . LEU A 1 248 ? -19.08166 -24.58597 -15.82053 1.000 14.07606 ? 1707 LEU A HD23 1 
ATOM   3942 N  N    . GLU A 1 249 ? -22.96378 -25.16146 -19.18567 1.000 10.67209 ? 1708 GLU A N    1 
ATOM   3943 C  CA   . GLU A 1 249 ? -23.14768 -25.70522 -20.52138 1.000 11.10371 ? 1708 GLU A CA   1 
ATOM   3944 C  C    . GLU A 1 249 ? -23.01984 -24.70067 -21.64422 1.000 11.68006 ? 1708 GLU A C    1 
ATOM   3945 O  O    . GLU A 1 249 ? -22.82569 -25.09288 -22.81068 1.000 12.78547 ? 1708 GLU A O    1 
ATOM   3946 C  CB   . GLU A 1 249 ? -24.51502 -26.42313 -20.58359 1.000 11.06156 ? 1708 GLU A CB   1 
ATOM   3947 C  CG   . GLU A 1 249 ? -24.48294 -27.73391 -19.77927 1.000 10.11422 ? 1708 GLU A CG   1 
ATOM   3948 C  CD   . GLU A 1 249 ? -25.87801 -28.27071 -19.47682 1.000 10.88264 ? 1708 GLU A CD   1 
ATOM   3949 O  OE1  . GLU A 1 249 ? -26.48423 -27.81979 -18.47961 1.000 11.60112 ? 1708 GLU A OE1  1 
ATOM   3950 O  OE2  . GLU A 1 249 ? -26.29789 -29.13204 -20.26323 1.000 12.25907 ? 1708 GLU A OE2  1 
ATOM   3951 H  H    . GLU A 1 249 ? -23.68559 -25.05122 -18.73131 1.000 12.80651 ? 1708 GLU A H    1 
ATOM   3952 H  HA   . GLU A 1 249 ? -22.44436 -26.35272 -20.68566 1.000 13.32446 ? 1708 GLU A HA   1 
ATOM   3953 H  HB2  . GLU A 1 249 ? -25.19933 -25.84747 -20.20778 1.000 13.27388 ? 1708 GLU A HB2  1 
ATOM   3954 H  HB3  . GLU A 1 249 ? -24.72793 -26.63280 -21.50641 1.000 13.27388 ? 1708 GLU A HB3  1 
ATOM   3955 H  HG2  . GLU A 1 249 ? -24.00606 -28.40698 -20.28962 1.000 12.13706 ? 1708 GLU A HG2  1 
ATOM   3956 H  HG3  . GLU A 1 249 ? -24.03197 -27.57641 -18.93504 1.000 12.13706 ? 1708 GLU A HG3  1 
ATOM   3957 N  N    . THR A 1 250 ? -23.14871 -23.41325 -21.35761 1.000 10.70106 ? 1709 THR A N    1 
ATOM   3958 C  CA   . THR A 1 250 ? -23.05707 -22.37117 -22.35524 1.000 10.49307 ? 1709 THR A CA   1 
ATOM   3959 C  C    . THR A 1 250 ? -21.74049 -21.59267 -22.38652 1.000 9.66145  ? 1709 THR A C    1 
ATOM   3960 O  O    . THR A 1 250 ? -21.46351 -20.94882 -23.40405 1.000 10.06671 ? 1709 THR A O    1 
ATOM   3961 C  CB   . THR A 1 250 ? -24.22136 -21.38883 -22.16174 1.000 11.01952 ? 1709 THR A CB   1 
ATOM   3962 O  OG1  . THR A 1 250 ? -24.31824 -20.97734 -20.80452 1.000 11.34058 ? 1709 THR A OG1  1 
ATOM   3963 C  CG2  . THR A 1 250 ? -25.54685 -22.04933 -22.55201 1.000 12.09855 ? 1709 THR A CG2  1 
ATOM   3964 H  H    . THR A 1 250 ? -23.29442 -23.11230 -20.56527 1.000 12.84128 ? 1709 THR A H    1 
ATOM   3965 H  HA   . THR A 1 250 ? -23.12785 -22.78909 -23.22772 1.000 12.59168 ? 1709 THR A HA   1 
ATOM   3966 H  HB   . THR A 1 250 ? -24.06145 -20.61397 -22.72292 1.000 13.22342 ? 1709 THR A HB   1 
ATOM   3967 H  HG1  . THR A 1 250 ? -24.95963 -20.44298 -20.71141 1.000 13.60870 ? 1709 THR A HG1  1 
ATOM   3968 H  HG21 . THR A 1 250 ? -26.27705 -21.42128 -22.43682 1.000 14.51826 ? 1709 THR A HG21 1 
ATOM   3969 H  HG22 . THR A 1 250 ? -25.51688 -22.33050 -23.47988 1.000 14.51826 ? 1709 THR A HG22 1 
ATOM   3970 H  HG23 . THR A 1 250 ? -25.70804 -22.82545 -21.99294 1.000 14.51826 ? 1709 THR A HG23 1 
ATOM   3971 N  N    . MET A 1 251 ? -20.91656 -21.66770 -21.33340 1.000 9.70359  ? 1710 MET A N    1 
ATOM   3972 C  CA   . MET A 1 251 ? -19.73463 -20.81972 -21.26087 1.000 9.81148  ? 1710 MET A CA   1 
ATOM   3973 C  C    . MET A 1 251 ? -18.79708 -21.01513 -22.42697 1.000 9.64304  ? 1710 MET A C    1 
ATOM   3974 O  O    . MET A 1 251 ? -18.43773 -20.05758 -23.13166 1.000 10.17991 ? 1710 MET A O    1 
ATOM   3975 C  CB   . MET A 1 251 ? -19.03143 -20.98265 -19.92309 1.000 9.87992  ? 1710 MET A CB   1 
ATOM   3976 C  CG   . MET A 1 251 ? -17.75784 -20.16583 -19.84670 1.000 10.87467 ? 1710 MET A CG   1 
ATOM   3977 S  SD   . MET A 1 251 ? -17.04428 -20.01036 -18.20243 1.000 11.18787 ? 1710 MET A SD   1 
ATOM   3978 C  CE   . MET A 1 251 ? -16.67727 -21.73481 -17.79063 1.000 12.08540 ? 1710 MET A CE   1 
ATOM   3979 H  H    . MET A 1 251 ? -21.02254 -22.19432 -20.66180 1.000 11.64431 ? 1710 MET A H    1 
ATOM   3980 H  HA   . MET A 1 251 ? -20.04312 -19.90108 -21.30370 1.000 11.77378 ? 1710 MET A HA   1 
ATOM   3981 H  HB2  . MET A 1 251 ? -19.62394 -20.68774 -19.21397 1.000 11.85590 ? 1710 MET A HB2  1 
ATOM   3982 H  HB3  . MET A 1 251 ? -18.80108 -21.91631 -19.79614 1.000 11.85590 ? 1710 MET A HB3  1 
ATOM   3983 H  HG2  . MET A 1 251 ? -17.09088 -20.58423 -20.41327 1.000 13.04961 ? 1710 MET A HG2  1 
ATOM   3984 H  HG3  . MET A 1 251 ? -17.94880 -19.26975 -20.16525 1.000 13.04961 ? 1710 MET A HG3  1 
ATOM   3985 H  HE1  . MET A 1 251 ? -16.23605 -21.76632 -16.92736 1.000 14.50248 ? 1710 MET A HE1  1 
ATOM   3986 H  HE2  . MET A 1 251 ? -17.50772 -22.23488 -17.75610 1.000 14.50248 ? 1710 MET A HE2  1 
ATOM   3987 H  HE3  . MET A 1 251 ? -16.09600 -22.10560 -18.47293 1.000 14.50248 ? 1710 MET A HE3  1 
ATOM   3988 N  N    . LEU A 1 252 ? -18.35614 -22.25607 -22.63814 1.000 10.09830 ? 1711 LEU A N    1 
ATOM   3989 C  CA   . LEU A 1 252 ? -17.36959 -22.49637 -23.69049 1.000 10.01415 ? 1711 LEU A CA   1 
ATOM   3990 C  C    . LEU A 1 252 ? -17.92754 -22.24498 -25.08885 1.000 10.49318 ? 1711 LEU A C    1 
ATOM   3991 O  O    . LEU A 1 252 ? -17.26822 -21.57044 -25.89129 1.000 11.21685 ? 1711 LEU A O    1 
ATOM   3992 C  CB   . LEU A 1 252 ? -16.72461 -23.87293 -23.52820 1.000 9.86154  ? 1711 LEU A CB   1 
ATOM   3993 C  CG   . LEU A 1 252 ? -15.64397 -24.19248 -24.56633 1.000 11.48009 ? 1711 LEU A CG   1 
ATOM   3994 C  CD1  . LEU A 1 252 ? -14.43757 -23.23591 -24.41136 1.000 12.39856 ? 1711 LEU A CD1  1 
ATOM   3995 C  CD2  . LEU A 1 252 ? -15.18262 -25.63035 -24.39664 1.000 12.30382 ? 1711 LEU A CD2  1 
ATOM   3996 H  H    . LEU A 1 252 ? -18.60520 -22.95251 -22.19934 1.000 12.11796 ? 1711 LEU A H    1 
ATOM   3997 H  HA   . LEU A 1 252 ? -16.65906 -21.84223 -23.60019 1.000 12.01698 ? 1711 LEU A HA   1 
ATOM   3998 H  HB2  . LEU A 1 252 ? -16.31266 -23.91924 -22.65125 1.000 11.83385 ? 1711 LEU A HB2  1 
ATOM   3999 H  HB3  . LEU A 1 252 ? -17.41604 -24.54878 -23.60604 1.000 11.83385 ? 1711 LEU A HB3  1 
ATOM   4000 H  HG   . LEU A 1 252 ? -16.01207 -24.07595 -25.45618 1.000 13.77610 ? 1711 LEU A HG   1 
ATOM   4001 H  HD11 . LEU A 1 252 ? -13.72702 -23.52499 -25.00504 1.000 14.87827 ? 1711 LEU A HD11 1 
ATOM   4002 H  HD12 . LEU A 1 252 ? -14.71629 -22.33606 -24.64266 1.000 14.87827 ? 1711 LEU A HD12 1 
ATOM   4003 H  HD13 . LEU A 1 252 ? -14.13077 -23.26100 -23.49150 1.000 14.87827 ? 1711 LEU A HD13 1 
ATOM   4004 H  HD21 . LEU A 1 252 ? -14.49410 -25.82063 -25.05287 1.000 14.76459 ? 1711 LEU A HD21 1 
ATOM   4005 H  HD22 . LEU A 1 252 ? -14.82690 -25.74431 -23.50144 1.000 14.76459 ? 1711 LEU A HD22 1 
ATOM   4006 H  HD23 . LEU A 1 252 ? -15.93921 -26.22257 -24.52980 1.000 14.76459 ? 1711 LEU A HD23 1 
ATOM   4007 N  N    . PRO A 1 253 ? -19.16898 -22.65788 -25.41054 1.000 10.89849 ? 1712 PRO A N    1 
ATOM   4008 C  CA   . PRO A 1 253 ? -19.71023 -22.27781 -26.72422 1.000 12.30123 ? 1712 PRO A CA   1 
ATOM   4009 C  C    . PRO A 1 253 ? -19.75556 -20.76764 -26.97472 1.000 10.34582 ? 1712 PRO A C    1 
ATOM   4010 O  O    . PRO A 1 253 ? -19.43698 -20.33172 -28.08140 1.000 11.63793 ? 1712 PRO A O    1 
ATOM   4011 C  CB   . PRO A 1 253 ? -21.12132 -22.92260 -26.71693 1.000 14.57773 ? 1712 PRO A CB   1 
ATOM   4012 C  CG   . PRO A 1 253 ? -20.95043 -24.12240 -25.85301 1.000 13.64865 ? 1712 PRO A CG   1 
ATOM   4013 C  CD   . PRO A 1 253 ? -19.98123 -23.70311 -24.75502 1.000 11.23272 ? 1712 PRO A CD   1 
ATOM   4014 H  HA   . PRO A 1 253 ? -19.17476 -22.68393 -27.42368 1.000 14.76147 ? 1712 PRO A HA   1 
ATOM   4015 H  HB2  . PRO A 1 253 ? -21.77025 -22.30719 -26.34134 1.000 17.49327 ? 1712 PRO A HB2  1 
ATOM   4016 H  HB3  . PRO A 1 253 ? -21.38219 -23.17090 -27.61760 1.000 17.49327 ? 1712 PRO A HB3  1 
ATOM   4017 H  HG2  . PRO A 1 253 ? -21.80646 -24.38025 -25.47665 1.000 16.37838 ? 1712 PRO A HG2  1 
ATOM   4018 H  HG3  . PRO A 1 253 ? -20.58398 -24.85312 -26.37518 1.000 16.37838 ? 1712 PRO A HG3  1 
ATOM   4019 H  HD2  . PRO A 1 253 ? -20.45812 -23.34289 -23.99101 1.000 13.47926 ? 1712 PRO A HD2  1 
ATOM   4020 H  HD3  . PRO A 1 253 ? -19.42717 -24.44970 -24.47838 1.000 13.47926 ? 1712 PRO A HD3  1 
ATOM   4021 N  N    . LEU A 1 254 ? -20.13313 -19.99805 -25.97111 1.000 10.40365 ? 1713 LEU A N    1 
ATOM   4022 C  CA   . LEU A 1 254 ? -20.14940 -18.54319 -26.13068 1.000 10.66417 ? 1713 LEU A CA   1 
ATOM   4023 C  C    . LEU A 1 254 ? -18.74326 -18.02674 -26.39656 1.000 10.66159 ? 1713 LEU A C    1 
ATOM   4024 O  O    . LEU A 1 254 ? -18.53843 -17.19973 -27.27736 1.000 11.15631 ? 1713 LEU A O    1 
ATOM   4025 C  CB   . LEU A 1 254 ? -20.69043 -17.87280 -24.87471 1.000 10.96690 ? 1713 LEU A CB   1 
ATOM   4026 C  CG   . LEU A 1 254 ? -22.20803 -18.07897 -24.60807 1.000 11.10905 ? 1713 LEU A CG   1 
ATOM   4027 C  CD1  . LEU A 1 254 ? -22.51934 -17.77387 -23.19845 1.000 10.90631 ? 1713 LEU A CD1  1 
ATOM   4028 C  CD2  . LEU A 1 254 ? -22.97082 -17.20079 -25.57664 1.000 12.61170 ? 1713 LEU A CD2  1 
ATOM   4029 H  H    . LEU A 1 254 ? -20.38174 -20.28031 -25.19773 1.000 12.48438 ? 1713 LEU A H    1 
ATOM   4030 H  HA   . LEU A 1 254 ? -20.73111 -18.32395 -26.87530 1.000 12.79701 ? 1713 LEU A HA   1 
ATOM   4031 H  HB2  . LEU A 1 254 ? -20.21122 -18.22763 -24.10963 1.000 13.16028 ? 1713 LEU A HB2  1 
ATOM   4032 H  HB3  . LEU A 1 254 ? -20.53660 -16.91795 -24.94884 1.000 13.16028 ? 1713 LEU A HB3  1 
ATOM   4033 H  HG   . LEU A 1 254 ? -22.47912 -18.99941 -24.75022 1.000 13.33086 ? 1713 LEU A HG   1 
ATOM   4034 H  HD11 . LEU A 1 254 ? -23.46984 -17.89888 -23.05076 1.000 13.08758 ? 1713 LEU A HD11 1 
ATOM   4035 H  HD12 . LEU A 1 254 ? -22.01416 -18.37285 -22.62669 1.000 13.08758 ? 1713 LEU A HD12 1 
ATOM   4036 H  HD13 . LEU A 1 254 ? -22.27391 -16.85399 -23.01280 1.000 13.08758 ? 1713 LEU A HD13 1 
ATOM   4037 H  HD21 . LEU A 1 254 ? -23.91939 -17.27026 -25.38613 1.000 15.13404 ? 1713 LEU A HD21 1 
ATOM   4038 H  HD22 . LEU A 1 254 ? -22.67803 -16.28242 -25.46810 1.000 15.13404 ? 1713 LEU A HD22 1 
ATOM   4039 H  HD23 . LEU A 1 254 ? -22.79248 -17.50002 -26.48194 1.000 15.13404 ? 1713 LEU A HD23 1 
ATOM   4040 N  N    . LEU A 1 255 ? -17.76402 -18.48571 -25.62094 1.000 10.72212 ? 1714 LEU A N    1 
ATOM   4041 C  CA   . LEU A 1 255 ? -16.38094 -18.01449 -25.79350 1.000 10.55110 ? 1714 LEU A CA   1 
ATOM   4042 C  C    . LEU A 1 255 ? -15.76665 -18.47831 -27.10564 1.000 11.66954 ? 1714 LEU A C    1 
ATOM   4043 O  O    . LEU A 1 255 ? -14.98668 -17.73944 -27.72857 1.000 11.96960 ? 1714 LEU A O    1 
ATOM   4044 C  CB   . LEU A 1 255 ? -15.55823 -18.40679 -24.57891 1.000 10.67209 ? 1714 LEU A CB   1 
ATOM   4045 C  CG   . LEU A 1 255 ? -15.93215 -17.65104 -23.32912 1.000 11.15636 ? 1714 LEU A CG   1 
ATOM   4046 C  CD1  . LEU A 1 255 ? -15.40396 -18.36616 -22.08845 1.000 11.25372 ? 1714 LEU A CD1  1 
ATOM   4047 C  CD2  . LEU A 1 255 ? -15.48332 -16.22117 -23.36776 1.000 12.67228 ? 1714 LEU A CD2  1 
ATOM   4048 H  H    . LEU A 1 255 ? -17.86600 -19.06395 -24.99258 1.000 12.86655 ? 1714 LEU A H    1 
ATOM   4049 H  HA   . LEU A 1 255 ? -16.37596 -17.04567 -25.84111 1.000 12.66132 ? 1714 LEU A HA   1 
ATOM   4050 H  HB2  . LEU A 1 255 ? -15.68898 -19.35217 -24.40554 1.000 12.80651 ? 1714 LEU A HB2  1 
ATOM   4051 H  HB3  . LEU A 1 255 ? -14.62287 -18.22992 -24.76521 1.000 12.80651 ? 1714 LEU A HB3  1 
ATOM   4052 H  HG   . LEU A 1 255 ? -16.90036 -17.62820 -23.27473 1.000 13.38763 ? 1714 LEU A HG   1 
ATOM   4053 H  HD11 . LEU A 1 255 ? -15.64550 -17.85318 -21.30143 1.000 13.50447 ? 1714 LEU A HD11 1 
ATOM   4054 H  HD12 . LEU A 1 255 ? -15.79972 -19.25049 -22.04118 1.000 13.50447 ? 1714 LEU A HD12 1 
ATOM   4055 H  HD13 . LEU A 1 255 ? -14.43881 -18.43870 -22.15265 1.000 13.50447 ? 1714 LEU A HD13 1 
ATOM   4056 H  HD21 . LEU A 1 255 ? -15.64469 -15.81600 -22.50133 1.000 15.20674 ? 1714 LEU A HD21 1 
ATOM   4057 H  HD22 . LEU A 1 255 ? -14.53610 -16.19300 -23.57484 1.000 15.20674 ? 1714 LEU A HD22 1 
ATOM   4058 H  HD23 . LEU A 1 255 ? -15.98553 -15.75090 -24.05153 1.000 15.20674 ? 1714 LEU A HD23 1 
ATOM   4059 N  N    . LEU A 1 256 ? -16.05138 -19.72664 -27.51934 1.000 11.72752 ? 1715 LEU A N    1 
ATOM   4060 C  CA   . LEU A 1 256 ? -15.57594 -20.17970 -28.81260 1.000 13.02497 ? 1715 LEU A CA   1 
ATOM   4061 C  C    . LEU A 1 256 ? -16.13197 -19.32962 -29.94562 1.000 12.64341 ? 1715 LEU A C    1 
ATOM   4062 O  O    . LEU A 1 256 ? -15.46635 -19.10142 -30.96250 1.000 13.13288 ? 1715 LEU A O    1 
ATOM   4063 C  CB   . LEU A 1 256 ? -15.94084 -21.65986 -29.04553 1.000 13.32245 ? 1715 LEU A CB   1 
ATOM   4064 C  CG   . LEU A 1 256 ? -15.15388 -22.65794 -28.16654 1.000 14.27514 ? 1715 LEU A CG   1 
ATOM   4065 C  CD1  . LEU A 1 256 ? -15.70774 -24.05657 -28.42590 1.000 15.34634 ? 1715 LEU A CD1  1 
ATOM   4066 C  CD2  . LEU A 1 256 ? -13.65859 -22.64393 -28.43857 1.000 15.25682 ? 1715 LEU A CD2  1 
ATOM   4067 H  H    . LEU A 1 256 ? -16.50581 -20.30561 -27.07450 1.000 14.07302 ? 1715 LEU A H    1 
ATOM   4068 H  HA   . LEU A 1 256 ? -14.60906 -20.10203 -28.81314 1.000 15.62996 ? 1715 LEU A HA   1 
ATOM   4069 H  HB2  . LEU A 1 256 ? -16.88407 -21.77909 -28.85321 1.000 15.98694 ? 1715 LEU A HB2  1 
ATOM   4070 H  HB3  . LEU A 1 256 ? -15.76098 -21.87974 -29.97300 1.000 15.98694 ? 1715 LEU A HB3  1 
ATOM   4071 H  HG   . LEU A 1 256 ? -15.26111 -22.40173 -27.23715 1.000 17.13017 ? 1715 LEU A HG   1 
ATOM   4072 H  HD11 . LEU A 1 256 ? -15.22755 -24.69370 -27.87419 1.000 18.41561 ? 1715 LEU A HD11 1 
ATOM   4073 H  HD12 . LEU A 1 256 ? -16.65122 -24.06932 -28.20101 1.000 18.41561 ? 1715 LEU A HD12 1 
ATOM   4074 H  HD13 . LEU A 1 256 ? -15.58819 -24.27473 -29.36345 1.000 18.41561 ? 1715 LEU A HD13 1 
ATOM   4075 H  HD21 . LEU A 1 256 ? -13.24205 -23.37161 -27.95084 1.000 18.30818 ? 1715 LEU A HD21 1 
ATOM   4076 H  HD22 . LEU A 1 256 ? -13.50973 -22.75584 -29.39052 1.000 18.30818 ? 1715 LEU A HD22 1 
ATOM   4077 H  HD23 . LEU A 1 256 ? -13.29193 -21.79562 -28.14391 1.000 18.30818 ? 1715 LEU A HD23 1 
ATOM   4078 N  N    . THR A 1 257 ? -17.37803 -18.89736 -29.82057 1.000 12.90390 ? 1716 THR A N    1 
ATOM   4079 C  CA   . THR A 1 257 ? -17.97582 -18.01712 -30.81127 1.000 12.81709 ? 1716 THR A CA   1 
ATOM   4080 C  C    . THR A 1 257 ? -17.15060 -16.74110 -30.92315 1.000 11.78024 ? 1716 THR A C    1 
ATOM   4081 O  O    . THR A 1 257 ? -16.83322 -16.27411 -32.01972 1.000 14.11979 ? 1716 THR A O    1 
ATOM   4082 C  CB   . THR A 1 257 ? -19.40883 -17.67772 -30.42283 1.000 13.55667 ? 1716 THR A CB   1 
ATOM   4083 O  OG1  . THR A 1 257 ? -20.18693 -18.86557 -30.27590 1.000 14.37511 ? 1716 THR A OG1  1 
ATOM   4084 C  CG2  . THR A 1 257 ? -20.07688 -16.82119 -31.55553 1.000 14.38302 ? 1716 THR A CG2  1 
ATOM   4085 H  H    . THR A 1 257 ? -17.90182 -19.09923 -29.16905 1.000 15.48468 ? 1716 THR A H    1 
ATOM   4086 H  HA   . THR A 1 257 ? -18.00192 -18.46620 -31.67065 1.000 15.38051 ? 1716 THR A HA   1 
ATOM   4087 H  HB   . THR A 1 257 ? -19.39412 -17.18776 -29.58580 1.000 16.26800 ? 1716 THR A HB   1 
ATOM   4088 H  HG1  . THR A 1 257 ? -19.85961 -19.35073 -29.67333 1.000 17.25013 ? 1716 THR A HG1  1 
ATOM   4089 H  HG21 . THR A 1 257 ? -21.02313 -16.71031 -31.37325 1.000 17.25963 ? 1716 THR A HG21 1 
ATOM   4090 H  HG22 . THR A 1 257 ? -19.66013 -15.94639 -31.59947 1.000 17.25963 ? 1716 THR A HG22 1 
ATOM   4091 H  HG23 . THR A 1 257 ? -19.97106 -17.26369 -32.41221 1.000 17.25963 ? 1716 THR A HG23 1 
ATOM   4092 N  N    . ALA A 1 258 ? -16.79609 -16.19976 -29.77565 1.000 12.27752 ? 1717 ALA A N    1 
ATOM   4093 C  CA   . ALA A 1 258 ? -15.97159 -14.97162 -29.75152 1.000 12.12761 ? 1717 ALA A CA   1 
ATOM   4094 C  C    . ALA A 1 258 ? -14.57398 -15.19880 -30.34305 1.000 12.60129 ? 1717 ALA A C    1 
ATOM   4095 O  O    . ALA A 1 258 ? -14.04386 -14.32701 -31.04332 1.000 13.73031 ? 1717 ALA A O    1 
ATOM   4096 C  CB   . ALA A 1 258 ? -15.88716 -14.44383 -28.32209 1.000 13.23815 ? 1717 ALA A CB   1 
ATOM   4097 H  H    . ALA A 1 258 ? -17.00744 -16.50547 -29.00010 1.000 14.73303 ? 1717 ALA A H    1 
ATOM   4098 H  HA   . ALA A 1 258 ? -16.40048 -14.29732 -30.30131 1.000 14.55314 ? 1717 ALA A HA   1 
ATOM   4099 H  HB1  . ALA A 1 258 ? -15.34676 -13.63834 -28.31426 1.000 15.88579 ? 1717 ALA A HB1  1 
ATOM   4100 H  HB2  . ALA A 1 258 ? -16.78219 -14.24476 -28.00557 1.000 15.88579 ? 1717 ALA A HB2  1 
ATOM   4101 H  HB3  . ALA A 1 258 ? -15.48011 -15.12072 -27.75904 1.000 15.88579 ? 1717 ALA A HB3  1 
ATOM   4102 N  N    . VAL A 1 259 ? -13.97731 -16.36927 -30.09198 1.000 12.23284 ? 1718 VAL A N    1 
ATOM   4103 C  CA   . VAL A 1 259 ? -12.69946 -16.69421 -30.73492 1.000 13.40930 ? 1718 VAL A CA   1 
ATOM   4104 C  C    . VAL A 1 259 ? -12.87115 -16.70939 -32.24881 1.000 15.43848 ? 1718 VAL A C    1 
ATOM   4105 O  O    . VAL A 1 259 ? -12.03658 -16.17408 -33.00141 1.000 15.73584 ? 1718 VAL A O    1 
ATOM   4106 C  CB   . VAL A 1 259 ? -12.13921 -18.00788 -30.20565 1.000 13.31198 ? 1718 VAL A CB   1 
ATOM   4107 C  CG1  . VAL A 1 259 ? -10.92692 -18.47663 -31.02974 1.000 15.31203 ? 1718 VAL A CG1  1 
ATOM   4108 C  CG2  . VAL A 1 259 ? -11.73837 -17.91517 -28.75366 1.000 13.68299 ? 1718 VAL A CG2  1 
ATOM   4109 H  H    . VAL A 1 259 ? -14.28338 -16.97755 -29.56670 1.000 14.67941 ? 1718 VAL A H    1 
ATOM   4110 H  HA   . VAL A 1 259 ? -12.05555 -16.00358 -30.51288 1.000 16.09116 ? 1718 VAL A HA   1 
ATOM   4111 H  HB   . VAL A 1 259 ? -12.85223 -18.66064 -30.28581 1.000 15.97437 ? 1718 VAL A HB   1 
ATOM   4112 H  HG11 . VAL A 1 259 ? -10.46069 -19.17112 -30.53861 1.000 18.37444 ? 1718 VAL A HG11 1 
ATOM   4113 H  HG12 . VAL A 1 259 ? -11.23849 -18.82491 -31.87975 1.000 18.37444 ? 1718 VAL A HG12 1 
ATOM   4114 H  HG13 . VAL A 1 259 ? -10.33528 -17.72241 -31.17817 1.000 18.37444 ? 1718 VAL A HG13 1 
ATOM   4115 H  HG21 . VAL A 1 259 ? -11.42254 -18.78308 -28.45720 1.000 16.41958 ? 1718 VAL A HG21 1 
ATOM   4116 H  HG22 . VAL A 1 259 ? -11.03152 -17.25716 -28.66258 1.000 16.41958 ? 1718 VAL A HG22 1 
ATOM   4117 H  HG23 . VAL A 1 259 ? -12.50939 -17.64707 -28.22969 1.000 16.41958 ? 1718 VAL A HG23 1 
ATOM   4118 N  N    . SER A 1 260 ? -13.94489 -17.35495 -32.72326 1.000 18.39146 ? 1719 SER A N    1 
ATOM   4119 C  CA   A SER A 1 260 ? -14.13627 -17.47914 -34.16671 0.283 19.65212 ? 1719 SER A CA   1 
ATOM   4120 C  CA   B SER A 1 260 ? -14.16651 -17.47594 -34.16388 0.717 20.06270 ? 1719 SER A CA   1 
ATOM   4121 C  C    . SER A 1 260 ? -14.31954 -16.12348 -34.83100 1.000 20.47850 ? 1719 SER A C    1 
ATOM   4122 O  O    . SER A 1 260 ? -13.97642 -15.96095 -36.01477 1.000 22.42077 ? 1719 SER A O    1 
ATOM   4123 C  CB   A SER A 1 260 ? -15.32987 -18.38433 -34.46223 0.283 20.28905 ? 1719 SER A CB   1 
ATOM   4124 C  CB   B SER A 1 260 ? -15.41539 -18.32556 -34.43990 0.717 21.85766 ? 1719 SER A CB   1 
ATOM   4125 O  OG   A SER A 1 260 ? -15.19441 -19.03434 -35.70949 0.283 20.96014 ? 1719 SER A OG   1 
ATOM   4126 O  OG   B SER A 1 260 ? -16.64683 -17.54370 -34.29355 0.717 23.54727 ? 1719 SER A OG   1 
ATOM   4127 H  H    A SER A 1 260 ? -14.55798 -17.71849 -32.24206 0.283 22.06976 ? 1719 SER A H    1 
ATOM   4128 H  H    B SER A 1 260 ? -14.54996 -17.72560 -32.23736 0.717 22.06976 ? 1719 SER A H    1 
ATOM   4129 H  HA   A SER A 1 260 ? -13.34611 -17.89152 -34.54944 0.283 23.58254 ? 1719 SER A HA   1 
ATOM   4130 H  HA   B SER A 1 260 ? -13.39598 -17.92153 -34.54941 0.717 24.07524 ? 1719 SER A HA   1 
ATOM   4131 H  HB2  A SER A 1 260 ? -15.39318 -19.05577 -33.76505 0.283 24.34686 ? 1719 SER A HB2  1 
ATOM   4132 H  HB2  B SER A 1 260 ? -15.36742 -18.66562 -35.34707 0.717 26.22920 ? 1719 SER A HB2  1 
ATOM   4133 H  HB3  A SER A 1 260 ? -16.13557 -17.84440 -34.47698 0.283 24.34686 ? 1719 SER A HB3  1 
ATOM   4134 H  HB3  B SER A 1 260 ? -15.43693 -19.06283 -33.80993 0.717 26.22920 ? 1719 SER A HB3  1 
ATOM   4135 H  HG   A SER A 1 260 ? -15.14803 -18.46588 -36.32618 0.283 25.15217 ? 1719 SER A HG   1 
ATOM   4136 H  HG   B SER A 1 260 ? -16.70440 -17.24204 -33.51170 0.717 28.25672 ? 1719 SER A HG   1 
ATOM   4137 N  N    . GLU A 1 261 ? -14.85542 -15.15063 -34.09736 1.000 19.67586 ? 1720 GLU A N    1 
ATOM   4138 C  CA   . GLU A 1 261 ? -15.03816 -13.78699 -34.55917 1.000 20.76799 ? 1720 GLU A CA   1 
ATOM   4139 C  C    . GLU A 1 261 ? -13.80177 -12.93420 -34.38125 1.000 20.24692 ? 1720 GLU A C    1 
ATOM   4140 O  O    . GLU A 1 261 ? -13.81984 -11.74751 -34.74450 1.000 22.07075 ? 1720 GLU A O    1 
ATOM   4141 C  CB   . GLU A 1 261 ? -16.20770 -13.17598 -33.79162 1.000 21.56028 ? 1720 GLU A CB   1 
ATOM   4142 C  CG   . GLU A 1 261 ? -17.51977 -13.82766 -34.14148 1.000 22.47355 ? 1720 GLU A CG   1 
ATOM   4143 C  CD   . GLU A 1 261 ? -18.68305 -13.28331 -33.35233 1.000 25.21067 ? 1720 GLU A CD   1 
ATOM   4144 O  OE1  . GLU A 1 261 ? -18.48945 -12.45705 -32.44681 1.000 25.99757 ? 1720 GLU A OE1  1 
ATOM   4145 O  OE2  . GLU A 1 261 ? -19.81055 -13.72141 -33.62557 1.000 26.82923 ? 1720 GLU A OE2  1 
ATOM   4146 H  H    . GLU A 1 261 ? -15.13252 -15.26587 -33.29142 1.000 23.61103 ? 1720 GLU A H    1 
ATOM   4147 H  HA   . GLU A 1 261 ? -15.24733 -13.78427 -35.50634 1.000 24.92159 ? 1720 GLU A HA   1 
ATOM   4148 H  HB2  . GLU A 1 261 ? -16.05743 -13.28944 -32.84007 1.000 25.87233 ? 1720 GLU A HB2  1 
ATOM   4149 H  HB3  . GLU A 1 261 ? -16.27120 -12.23239 -34.00727 1.000 25.87233 ? 1720 GLU A HB3  1 
ATOM   4150 H  HG2  . GLU A 1 261 ? -17.70298 -13.67998 -35.08251 1.000 26.96826 ? 1720 GLU A HG2  1 
ATOM   4151 H  HG3  . GLU A 1 261 ? -17.45633 -14.77863 -33.96110 1.000 26.96826 ? 1720 GLU A HG3  1 
ATOM   4152 N  N    . GLY A 1 262 ? -12.72612 -13.47952 -33.81003 1.000 18.73099 ? 1721 GLY A N    1 
ATOM   4153 C  CA   . GLY A 1 262 ? -11.51715 -12.68081 -33.64485 1.000 18.23088 ? 1721 GLY A CA   1 
ATOM   4154 C  C    . GLY A 1 262 ? -11.55857 -11.73318 -32.46838 1.000 17.63081 ? 1721 GLY A C    1 
ATOM   4155 O  O    . GLY A 1 262 ? -10.70852 -10.83153 -32.39622 1.000 19.38890 ? 1721 GLY A O    1 
ATOM   4156 H  H    . GLY A 1 262 ? -12.67478 -14.28707 -33.51877 1.000 22.47719 ? 1721 GLY A H    1 
ATOM   4157 H  HA2  . GLY A 1 262 ? -10.76192 -13.27699 -33.52201 1.000 21.87706 ? 1721 GLY A HA2  1 
ATOM   4158 H  HA3  . GLY A 1 262 ? -11.37688 -12.15472 -34.44763 1.000 21.87706 ? 1721 GLY A HA3  1 
ATOM   4159 N  N    . ARG A 1 263 ? -12.50951 -11.90160 -31.54402 1.000 15.13851 ? 1722 ARG A N    1 
ATOM   4160 C  CA   . ARG A 1 263 ? -12.58542 -11.00845 -30.37690 1.000 15.96218 ? 1722 ARG A CA   1 
ATOM   4161 C  C    . ARG A 1 263 ? -11.54858 -11.30363 -29.31624 1.000 15.27267 ? 1722 ARG A C    1 
ATOM   4162 O  O    . ARG A 1 263 ? -11.21075 -10.42593 -28.50791 1.000 16.55433 ? 1722 ARG A O    1 
ATOM   4163 C  CB   . ARG A 1 263 ? -13.97106 -11.05270 -29.75170 1.000 15.91229 ? 1722 ARG A CB   1 
ATOM   4164 C  CG   . ARG A 1 263 ? -15.09123 -10.79026 -30.71705 1.000 18.15972 ? 1722 ARG A CG   1 
ATOM   4165 C  CD   . ARG A 1 263 ? -16.42190 -10.87070 -30.03903 1.000 17.57557 ? 1722 ARG A CD   1 
ATOM   4166 N  NE   . ARG A 1 263 ? -16.65094 -9.76496  -29.11148 1.000 18.23618 ? 1722 ARG A NE   1 
ATOM   4167 C  CZ   . ARG A 1 263 ? -17.74764 -9.60056  -28.39281 1.000 19.19682 ? 1722 ARG A CZ   1 
ATOM   4168 N  NH1  . ARG A 1 263 ? -18.69554 -10.50658 -28.38477 1.000 19.67840 ? 1722 ARG A NH1  1 
ATOM   4169 N  NH2  . ARG A 1 263 ? -17.86856 -8.51263  -27.63498 1.000 20.63112 ? 1722 ARG A NH2  1 
ATOM   4170 H  H    . ARG A 1 263 ? -13.11312 -12.51377 -31.56661 1.000 18.16621 ? 1722 ARG A H    1 
ATOM   4171 H  HA   . ARG A 1 263 ? -12.42898 -10.10538 -30.69453 1.000 19.15462 ? 1722 ARG A HA   1 
ATOM   4172 H  HB2  . ARG A 1 263 ? -14.11130 -11.93370 -29.37082 1.000 19.09475 ? 1722 ARG A HB2  1 
ATOM   4173 H  HB3  . ARG A 1 263 ? -14.01871 -10.37889 -29.05556 1.000 19.09475 ? 1722 ARG A HB3  1 
ATOM   4174 H  HG2  . ARG A 1 263 ? -14.99210 -9.90097  -31.09154 1.000 21.79167 ? 1722 ARG A HG2  1 
ATOM   4175 H  HG3  . ARG A 1 263 ? -15.06823 -11.45286 -31.42510 1.000 21.79167 ? 1722 ARG A HG3  1 
ATOM   4176 H  HD2  . ARG A 1 263 ? -17.12118 -10.84820 -30.71090 1.000 21.09069 ? 1722 ARG A HD2  1 
ATOM   4177 H  HD3  . ARG A 1 263 ? -16.47130 -11.69884 -29.53639 1.000 21.09069 ? 1722 ARG A HD3  1 
ATOM   4178 H  HE   . ARG A 1 263 ? -16.02708 -9.17904  -29.02724 1.000 21.88342 ? 1722 ARG A HE   1 
ATOM   4179 H  HH11 . ARG A 1 263 ? -18.60956 -11.22302 -28.85267 1.000 23.61408 ? 1722 ARG A HH11 1 
ATOM   4180 H  HH12 . ARG A 1 263 ? -19.40319 -10.38436 -27.91161 1.000 23.61408 ? 1722 ARG A HH12 1 
ATOM   4181 H  HH21 . ARG A 1 263 ? -17.23777 -7.92833  -27.61771 1.000 24.75735 ? 1722 ARG A HH21 1 
ATOM   4182 H  HH22 . ARG A 1 263 ? -18.57745 -8.39418  -27.16271 1.000 24.75735 ? 1722 ARG A HH22 1 
ATOM   4183 N  N    . LEU A 1 264 ? -11.04769 -12.52511 -29.27535 1.000 14.64096 ? 1723 LEU A N    1 
ATOM   4184 C  CA   . LEU A 1 264 ? -9.91283  -12.96430 -28.46348 1.000 13.75929 ? 1723 LEU A CA   1 
ATOM   4185 C  C    . LEU A 1 264 ? -9.35683  -14.19446 -29.17267 1.000 13.16184 ? 1723 LEU A C    1 
ATOM   4186 O  O    . LEU A 1 264 ? -10.01473 -14.78522 -30.03583 1.000 13.18554 ? 1723 LEU A O    1 
ATOM   4187 C  CB   . LEU A 1 264 ? -10.23004 -13.22080 -27.01136 1.000 13.11720 ? 1723 LEU A CB   1 
ATOM   4188 C  CG   . LEU A 1 264 ? -10.98742 -14.54793 -26.69400 1.000 13.99361 ? 1723 LEU A CG   1 
ATOM   4189 C  CD1  . LEU A 1 264 ? -11.08722 -14.66821 -25.16422 1.000 16.29110 ? 1723 LEU A CD1  1 
ATOM   4190 C  CD2  . LEU A 1 264 ? -12.34111 -14.56975 -27.34394 1.000 14.10144 ? 1723 LEU A CD2  1 
ATOM   4191 H  H    . LEU A 1 264 ? -11.36713 -13.17289 -29.74218 1.000 17.56915 ? 1723 LEU A H    1 
ATOM   4192 H  HA   . LEU A 1 264 ? -9.24225  -12.26450 -28.42473 1.000 16.51114 ? 1723 LEU A HA   1 
ATOM   4193 H  HB2  . LEU A 1 264 ? -9.39413  -13.24388 -26.51980 1.000 15.74063 ? 1723 LEU A HB2  1 
ATOM   4194 H  HB3  . LEU A 1 264 ? -10.78359 -12.49175 -26.69046 1.000 15.74063 ? 1723 LEU A HB3  1 
ATOM   4195 H  HG   . LEU A 1 264 ? -10.51140 -15.31418 -27.05060 1.000 16.79233 ? 1723 LEU A HG   1 
ATOM   4196 H  HD11 . LEU A 1 264 ? -11.55972 -15.48564 -24.94187 1.000 19.54932 ? 1723 LEU A HD11 1 
ATOM   4197 H  HD12 . LEU A 1 264 ? -10.19252 -14.69112 -24.79020 1.000 19.54932 ? 1723 LEU A HD12 1 
ATOM   4198 H  HD13 . LEU A 1 264 ? -11.57091 -13.90196 -24.81809 1.000 19.54932 ? 1723 LEU A HD13 1 
ATOM   4199 H  HD21 . LEU A 1 264 ? -12.83002 -15.34619 -27.02928 1.000 16.92173 ? 1723 LEU A HD21 1 
ATOM   4200 H  HD22 . LEU A 1 264 ? -12.81860 -13.75954 -27.10632 1.000 16.92173 ? 1723 LEU A HD22 1 
ATOM   4201 H  HD23 . LEU A 1 264 ? -12.22867 -14.61728 -28.30623 1.000 16.92173 ? 1723 LEU A HD23 1 
ATOM   4202 N  N    . SER A 1 265 ? -8.12739  -14.55790 -28.83326 1.000 12.57236 ? 1724 SER A N    1 
ATOM   4203 C  CA   . SER A 1 265 ? -7.48675  -15.70072 -29.46436 1.000 12.18012 ? 1724 SER A CA   1 
ATOM   4204 C  C    . SER A 1 265 ? -7.79062  -16.98897 -28.69468 1.000 11.41694 ? 1724 SER A C    1 
ATOM   4205 O  O    . SER A 1 265 ? -8.23327  -16.98721 -27.54271 1.000 12.15651 ? 1724 SER A O    1 
ATOM   4206 C  CB   . SER A 1 265 ? -5.96286  -15.50189 -29.54389 1.000 12.05384 ? 1724 SER A CB   1 
ATOM   4207 O  OG   . SER A 1 265 ? -5.46703  -15.52315 -28.24729 1.000 11.68799 ? 1724 SER A OG   1 
ATOM   4208 H  H    . SER A 1 265 ? -7.64597  -14.15967 -28.24230 1.000 15.08683 ? 1724 SER A H    1 
ATOM   4209 H  HA   . SER A 1 265 ? -7.83612  -15.78305 -30.36550 1.000 14.61614 ? 1724 SER A HA   1 
ATOM   4210 H  HB2  . SER A 1 265 ? -5.56446  -16.22037 -30.05961 1.000 14.46461 ? 1724 SER A HB2  1 
ATOM   4211 H  HB3  . SER A 1 265 ? -5.76439  -14.64716 -29.95735 1.000 14.46461 ? 1724 SER A HB3  1 
ATOM   4212 H  HG   . SER A 1 265 ? -4.63261  -15.42704 -28.25718 1.000 14.02559 ? 1724 SER A HG   1 
ATOM   4213 N  N    . LEU A 1 266 ? -7.49374  -18.12040 -29.35425 1.000 11.65900 ? 1725 LEU A N    1 
ATOM   4214 C  CA   . LEU A 1 266 ? -7.57144  -19.39286 -28.67173 1.000 12.11433 ? 1725 LEU A CA   1 
ATOM   4215 C  C    . LEU A 1 266 ? -6.64817  -19.41987 -27.46710 1.000 9.57214  ? 1725 LEU A C    1 
ATOM   4216 O  O    . LEU A 1 266 ? -7.03502  -19.84413 -26.38282 1.000 10.68518 ? 1725 LEU A O    1 
ATOM   4217 C  CB   . LEU A 1 266 ? -7.25334  -20.52074 -29.63284 1.000 13.04606 ? 1725 LEU A CB   1 
ATOM   4218 C  CG   . LEU A 1 266 ? -7.36825  -21.92002 -29.01256 1.000 14.29887 ? 1725 LEU A CG   1 
ATOM   4219 C  CD1  . LEU A 1 266 ? -8.78420  -22.25920 -28.63827 1.000 15.87533 ? 1725 LEU A CD1  1 
ATOM   4220 C  CD2  . LEU A 1 266 ? -6.81605  -22.94321 -30.00985 1.000 16.10161 ? 1725 LEU A CD2  1 
ATOM   4221 H  H    . LEU A 1 266 ? -7.25148  -18.16459 -30.17824 1.000 13.99079 ? 1725 LEU A H    1 
ATOM   4222 H  HA   . LEU A 1 266 ? -8.47763  -19.52923 -28.35375 1.000 14.53719 ? 1725 LEU A HA   1 
ATOM   4223 H  HB2  . LEU A 1 266 ? -7.87155  -20.47623 -30.37899 1.000 15.65527 ? 1725 LEU A HB2  1 
ATOM   4224 H  HB3  . LEU A 1 266 ? -6.34297  -20.41128 -29.94929 1.000 15.65527 ? 1725 LEU A HB3  1 
ATOM   4225 H  HG   . LEU A 1 266 ? -6.85487  -21.94778 -28.19002 1.000 17.15865 ? 1725 LEU A HG   1 
ATOM   4226 H  HD11 . LEU A 1 266 ? -8.82007  -23.18211 -28.34188 1.000 19.05040 ? 1725 LEU A HD11 1 
ATOM   4227 H  HD12 . LEU A 1 266 ? -9.07134  -21.67059 -27.92273 1.000 19.05040 ? 1725 LEU A HD12 1 
ATOM   4228 H  HD13 . LEU A 1 266 ? -9.35351  -22.13864 -29.41431 1.000 19.05040 ? 1725 LEU A HD13 1 
ATOM   4229 H  HD21 . LEU A 1 266 ? -6.89379  -23.83107 -29.62703 1.000 19.32194 ? 1725 LEU A HD21 1 
ATOM   4230 H  HD22 . LEU A 1 266 ? -7.32848  -22.89137 -30.83182 1.000 19.32194 ? 1725 LEU A HD22 1 
ATOM   4231 H  HD23 . LEU A 1 266 ? -5.88436  -22.74001 -30.18751 1.000 19.32194 ? 1725 LEU A HD23 1 
ATOM   4232 N  N    . ASP A 1 267 ? -5.42673  -18.87657 -27.60406 1.000 10.14835 ? 1726 ASP A N    1 
ATOM   4233 C  CA   . ASP A 1 267 ? -4.55308  -18.80206 -26.45417 1.000 9.78514  ? 1726 ASP A CA   1 
ATOM   4234 C  C    . ASP A 1 267 ? -5.14967  -17.96545 -25.30496 1.000 7.30881  ? 1726 ASP A C    1 
ATOM   4235 O  O    . ASP A 1 267 ? -5.06969  -18.31442 -24.16101 1.000 8.55598  ? 1726 ASP A O    1 
ATOM   4236 C  CB   . ASP A 1 267 ? -3.18533  -18.20607 -26.86531 1.000 12.38554 ? 1726 ASP A CB   1 
ATOM   4237 C  CG   . ASP A 1 267 ? -2.28344  -17.98992 -25.67544 1.000 17.00437 ? 1726 ASP A CG   1 
ATOM   4238 O  OD1  . ASP A 1 267 ? -1.94657  -19.00541 -25.07443 1.000 16.99908 ? 1726 ASP A OD1  1 
ATOM   4239 O  OD2  . ASP A 1 267 ? -1.99710  -16.79355 -25.33153 1.000 19.22564 ? 1726 ASP A OD2  1 
ATOM   4240 H  H    . ASP A 1 267 ? -5.10215  -18.55766 -28.33382 1.000 12.17802 ? 1726 ASP A H    1 
ATOM   4241 H  HA   . ASP A 1 267 ? -4.42697  -19.70687 -26.12809 1.000 11.74217 ? 1726 ASP A HA   1 
ATOM   4242 H  HB2  . ASP A 1 267 ? -2.74177  -18.81608 -27.47526 1.000 14.86265 ? 1726 ASP A HB2  1 
ATOM   4243 H  HB3  . ASP A 1 267 ? -3.32746  -17.34950 -27.29773 1.000 14.86265 ? 1726 ASP A HB3  1 
ATOM   4244 N  N    . ASP A 1 268 ? -5.75389  -16.80314 -25.65433 1.000 10.97469 ? 1727 ASP A N    1 
ATOM   4245 C  CA   . ASP A 1 268 ? -6.35689  -15.95394 -24.62775 1.000 11.80115 ? 1727 ASP A CA   1 
ATOM   4246 C  C    . ASP A 1 268 ? -7.38211  -16.76822 -23.83682 1.000 10.31153 ? 1727 ASP A C    1 
ATOM   4247 O  O    . ASP A 1 268 ? -7.46165  -16.65986 -22.62045 1.000 10.37997 ? 1727 ASP A O    1 
ATOM   4248 C  CB   . ASP A 1 268 ? -7.05861  -14.76160 -25.27319 1.000 13.11450 ? 1727 ASP A CB   1 
ATOM   4249 C  CG   . ASP A 1 268 ? -6.14003  -13.73792 -25.91430 1.000 14.78580 ? 1727 ASP A CG   1 
ATOM   4250 O  OD1  . ASP A 1 268 ? -4.93618  -13.65210 -25.57466 1.000 16.40164 ? 1727 ASP A OD1  1 
ATOM   4251 O  OD2  . ASP A 1 268 ? -6.65685  -13.03554 -26.81540 1.000 15.10680 ? 1727 ASP A OD2  1 
ATOM   4252 H  H    . ASP A 1 268 ? -5.82051  -16.50226 -26.45722 1.000 13.16963 ? 1727 ASP A H    1 
ATOM   4253 H  HA   . ASP A 1 268 ? -5.66372  -15.61760 -24.03843 1.000 14.16138 ? 1727 ASP A HA   1 
ATOM   4254 H  HB2  . ASP A 1 268 ? -7.65059  -15.09308 -25.96643 1.000 15.73740 ? 1727 ASP A HB2  1 
ATOM   4255 H  HB3  . ASP A 1 268 ? -7.57191  -14.30194 -24.59045 1.000 15.73740 ? 1727 ASP A HB3  1 
ATOM   4256 N  N    . LEU A 1 269 ? -8.15814  -17.58999 -24.53554 1.000 11.13266 ? 1728 LEU A N    1 
ATOM   4257 C  CA   A LEU A 1 269 ? -9.15829  -18.40772 -23.89687 0.749 11.40107 ? 1728 LEU A CA   1 
ATOM   4258 C  CA   B LEU A 1 269 ? -9.16691  -18.41114 -23.89543 0.251 10.98525 ? 1728 LEU A CA   1 
ATOM   4259 C  C    . LEU A 1 269 ? -8.52800  -19.45128 -22.99743 1.000 10.75106 ? 1728 LEU A C    1 
ATOM   4260 O  O    . LEU A 1 269 ? -8.97124  -19.65298 -21.85987 1.000 11.17740 ? 1728 LEU A O    1 
ATOM   4261 C  CB   A LEU A 1 269 ? -9.99372  -19.06212 -24.99132 0.749 11.66960 ? 1728 LEU A CB   1 
ATOM   4262 C  CB   B LEU A 1 269 ? -10.02054 -19.08797 -24.96733 0.251 10.71156 ? 1728 LEU A CB   1 
ATOM   4263 C  CG   A LEU A 1 269 ? -11.09835 -19.99204 -24.51286 0.749 13.45405 ? 1728 LEU A CG   1 
ATOM   4264 C  CG   B LEU A 1 269 ? -11.19615 -19.95464 -24.51027 0.251 10.78528 ? 1728 LEU A CG   1 
ATOM   4265 C  CD1  A LEU A 1 269 ? -12.02248 -19.26646 -23.59125 0.749 14.64622 ? 1728 LEU A CD1  1 
ATOM   4266 C  CD1  B LEU A 1 269 ? -12.22463 -20.03336 -25.63026 0.251 11.14057 ? 1728 LEU A CD1  1 
ATOM   4267 C  CD2  A LEU A 1 269 ? -11.83133 -20.56586 -25.72883 0.749 15.23835 ? 1728 LEU A CD2  1 
ATOM   4268 C  CD2  B LEU A 1 269 ? -10.77332 -21.37336 -24.09711 0.251 10.93527 ? 1728 LEU A CD2  1 
ATOM   4269 H  H    A LEU A 1 269 ? -8.11966  -17.68851 -25.38901 0.749 13.35919 ? 1728 LEU A H    1 
ATOM   4270 H  H    B LEU A 1 269 ? -8.11807  -17.68947 -25.38883 0.251 13.35919 ? 1728 LEU A H    1 
ATOM   4271 H  HA   A LEU A 1 269 ? -9.73227  -17.86236 -23.33648 0.749 13.68129 ? 1728 LEU A HA   1 
ATOM   4272 H  HA   B LEU A 1 269 ? -9.74063  -17.85114 -23.34939 0.251 13.18230 ? 1728 LEU A HA   1 
ATOM   4273 H  HB2  A LEU A 1 269 ? -10.41355 -18.36034 -25.51300 0.749 14.00352 ? 1728 LEU A HB2  1 
ATOM   4274 H  HB2  B LEU A 1 269 ? -10.39116 -18.39142 -25.53156 0.251 12.85388 ? 1728 LEU A HB2  1 
ATOM   4275 H  HB3  A LEU A 1 269 ? -9.40090  -19.58438 -25.55409 0.749 14.00352 ? 1728 LEU A HB3  1 
ATOM   4276 H  HB3  B LEU A 1 269 ? -9.43772  -19.66206 -25.48853 0.251 12.85388 ? 1728 LEU A HB3  1 
ATOM   4277 H  HG   A LEU A 1 269 ? -10.72792 -20.73380 -24.00941 0.749 16.14486 ? 1728 LEU A HG   1 
ATOM   4278 H  HG   B LEU A 1 269 ? -11.58157 -19.54147 -23.72183 0.251 12.94234 ? 1728 LEU A HG   1 
ATOM   4279 H  HD11 A LEU A 1 269 ? -12.81003 -19.81209 -23.43970 0.749 17.57547 ? 1728 LEU A HD11 1 
ATOM   4280 H  HD11 B LEU A 1 269 ? -12.96258 -20.59334 -25.34257 0.251 13.36869 ? 1728 LEU A HD11 1 
ATOM   4281 H  HD12 A LEU A 1 269 ? -11.56646 -19.10319 -22.75083 0.749 17.57547 ? 1728 LEU A HD12 1 
ATOM   4282 H  HD12 B LEU A 1 269 ? -12.54523 -19.13949 -25.82801 0.251 13.36869 ? 1728 LEU A HD12 1 
ATOM   4283 H  HD13 A LEU A 1 269 ? -12.27727 -18.42377 -23.99849 0.749 17.57547 ? 1728 LEU A HD13 1 
ATOM   4284 H  HD13 B LEU A 1 269 ? -11.80604 -20.41625 -26.41707 0.251 13.36869 ? 1728 LEU A HD13 1 
ATOM   4285 H  HD21 A LEU A 1 269 ? -12.53772 -21.15576 -25.42236 0.749 18.28603 ? 1728 LEU A HD21 1 
ATOM   4286 H  HD21 B LEU A 1 269 ? -11.55347 -21.94976 -24.10316 0.251 13.12233 ? 1728 LEU A HD21 1 
ATOM   4287 H  HD22 A LEU A 1 269 ? -12.20996 -19.83562 -26.24291 0.749 18.28603 ? 1728 LEU A HD22 1 
ATOM   4288 H  HD22 B LEU A 1 269 ? -10.11391 -21.70260 -24.72773 0.251 13.12233 ? 1728 LEU A HD22 1 
ATOM   4289 H  HD23 A LEU A 1 269 ? -11.19976 -21.06121 -26.27349 0.749 18.28603 ? 1728 LEU A HD23 1 
ATOM   4290 H  HD23 B LEU A 1 269 ? -10.39194 -21.34225 -23.20578 0.251 13.12233 ? 1728 LEU A HD23 1 
ATOM   4291 N  N    . LEU A 1 270 ? -7.44563  -20.10450 -23.48503 1.000 10.82215 ? 1729 LEU A N    1 
ATOM   4292 C  CA   . LEU A 1 270 ? -6.79394  -21.16236 -22.72247 1.000 10.87208 ? 1729 LEU A CA   1 
ATOM   4293 C  C    . LEU A 1 270 ? -6.01577  -20.63656 -21.51643 1.000 8.62459  ? 1729 LEU A C    1 
ATOM   4294 O  O    . LEU A 1 270 ? -5.94633  -21.30858 -20.47982 1.000 10.64045 ? 1729 LEU A O    1 
ATOM   4295 C  CB   . LEU A 1 270 ? -5.94152  -22.02399 -23.63236 1.000 12.75918 ? 1729 LEU A CB   1 
ATOM   4296 C  CG   . LEU A 1 270 ? -6.81713  -22.81712 -24.66211 1.000 14.27257 ? 1729 LEU A CG   1 
ATOM   4297 C  CD1  . LEU A 1 270 ? -5.94900  -23.67398 -25.51687 1.000 16.22269 ? 1729 LEU A CD1  1 
ATOM   4298 C  CD2  . LEU A 1 270 ? -7.91462  -23.67550 -23.97636 1.000 16.46221 ? 1729 LEU A CD2  1 
ATOM   4299 H  H    . LEU A 1 270 ? -7.08235  -19.94642 -24.24834 1.000 12.98658 ? 1729 LEU A H    1 
ATOM   4300 H  HA   . LEU A 1 270 ? -7.48044  -21.74154 -22.35617 1.000 13.04649 ? 1729 LEU A HA   1 
ATOM   4301 H  HB2  . LEU A 1 270 ? -5.32718  -21.45781 -24.12523 1.000 15.31102 ? 1729 LEU A HB2  1 
ATOM   4302 H  HB3  . LEU A 1 270 ? -5.44634  -22.66268 -23.09590 1.000 15.31102 ? 1729 LEU A HB3  1 
ATOM   4303 H  HG   . LEU A 1 270 ? -7.27873  -22.17081 -25.21899 1.000 17.12708 ? 1729 LEU A HG   1 
ATOM   4304 H  HD11 . LEU A 1 270 ? -6.50437  -24.15033 -26.15370 1.000 19.46723 ? 1729 LEU A HD11 1 
ATOM   4305 H  HD12 . LEU A 1 270 ? -5.31469  -23.11085 -25.98744 1.000 19.46723 ? 1729 LEU A HD12 1 
ATOM   4306 H  HD13 . LEU A 1 270 ? -5.47575  -24.30577 -24.95317 1.000 19.46723 ? 1729 LEU A HD13 1 
ATOM   4307 H  HD21 . LEU A 1 270 ? -8.26565  -24.31152 -24.61914 1.000 19.75465 ? 1729 LEU A HD21 1 
ATOM   4308 H  HD22 . LEU A 1 270 ? -7.52296  -24.14698 -23.22456 1.000 19.75465 ? 1729 LEU A HD22 1 
ATOM   4309 H  HD23 . LEU A 1 270 ? -8.62481  -23.09168 -23.66703 1.000 19.75465 ? 1729 LEU A HD23 1 
ATOM   4310 N  N    . GLN A 1 271 ? -5.47405  -19.41848 -21.60089 1.000 8.63503  ? 1730 GLN A N    1 
ATOM   4311 C  CA   . GLN A 1 271 ? -4.94061  -18.80964 -20.39229 1.000 8.77711  ? 1730 GLN A CA   1 
ATOM   4312 C  C    . GLN A 1 271 ? -6.03440  -18.70350 -19.32401 1.000 6.55329  ? 1730 GLN A C    1 
ATOM   4313 O  O    . GLN A 1 271 ? -5.82601  -18.94931 -18.14907 1.000 7.99016  ? 1730 GLN A O    1 
ATOM   4314 C  CB   . GLN A 1 271 ? -4.32984  -17.44076 -20.71303 1.000 10.35887 ? 1730 GLN A CB   1 
ATOM   4315 C  CG   . GLN A 1 271 ? -3.17467  -17.50257 -21.68328 1.000 10.32733 ? 1730 GLN A CG   1 
ATOM   4316 C  CD   . GLN A 1 271 ? -2.01909  -18.38213 -21.23722 1.000 10.53530 ? 1730 GLN A CD   1 
ATOM   4317 O  OE1  . GLN A 1 271 ? -1.68991  -18.43467 -20.04063 1.000 10.49834 ? 1730 GLN A OE1  1 
ATOM   4318 N  NE2  . GLN A 1 271 ? -1.42361  -19.07943 -22.17689 1.000 11.80371 ? 1730 GLN A NE2  1 
ATOM   4319 H  H    . GLN A 1 271 ? -5.40799  -18.94715 -22.31719 1.000 10.36204 ? 1730 GLN A H    1 
ATOM   4320 H  HA   . GLN A 1 271 ? -4.22550  -19.36018 -20.03672 1.000 10.53253 ? 1730 GLN A HA   1 
ATOM   4321 H  HB2  . GLN A 1 271 ? -5.01558  -16.87734 -21.10447 1.000 12.43064 ? 1730 GLN A HB2  1 
ATOM   4322 H  HB3  . GLN A 1 271 ? -4.00438  -17.04393 -19.88993 1.000 12.43064 ? 1730 GLN A HB3  1 
ATOM   4323 H  HG2  . GLN A 1 271 ? -3.49902  -17.85280 -22.52769 1.000 12.39280 ? 1730 GLN A HG2  1 
ATOM   4324 H  HG3  . GLN A 1 271 ? -2.82750  -16.60540 -21.80765 1.000 12.39280 ? 1730 GLN A HG3  1 
ATOM   4325 H  HE21 . GLN A 1 271 ? -1.69365  -19.02209 -22.99138 1.000 14.16445 ? 1730 GLN A HE21 1 
ATOM   4326 H  HE22 . GLN A 1 271 ? -0.76351  -19.59351 -21.97790 1.000 14.16445 ? 1730 GLN A HE22 1 
ATOM   4327 N  N    . ARG A 1 272 ? -7.22365  -18.23343 -19.73862 1.000 8.65863  ? 1731 ARG A N    1 
ATOM   4328 C  CA   . ARG A 1 272 ? -8.25434  -17.86672 -18.79713 1.000 8.80607  ? 1731 ARG A CA   1 
ATOM   4329 C  C    . ARG A 1 272 ? -9.11168  -19.03110 -18.31944 1.000 9.30874  ? 1731 ARG A C    1 
ATOM   4330 O  O    . ARG A 1 272 ? -9.72232  -18.88719 -17.25817 1.000 9.51669  ? 1731 ARG A O    1 
ATOM   4331 C  CB   . ARG A 1 272 ? -9.07432  -16.76077 -19.42586 1.000 8.81659  ? 1731 ARG A CB   1 
ATOM   4332 C  CG   . ARG A 1 272 ? -8.25989  -15.44496 -19.49794 1.000 9.41669  ? 1731 ARG A CG   1 
ATOM   4333 C  CD   . ARG A 1 272 ? -8.84639  -14.40880 -20.44220 1.000 9.48508  ? 1731 ARG A CD   1 
ATOM   4334 N  NE   . ARG A 1 272 ? -8.03044  -13.16830 -20.41669 1.000 9.83781  ? 1731 ARG A NE   1 
ATOM   4335 C  CZ   . ARG A 1 272 ? -6.84270  -13.07330 -21.00092 1.000 11.34592 ? 1731 ARG A CZ   1 
ATOM   4336 N  NH1  . ARG A 1 272 ? -6.38921  -14.01353 -21.79592 1.000 12.30119 ? 1731 ARG A NH1  1 
ATOM   4337 N  NH2  . ARG A 1 272 ? -6.11895  -11.98347 -20.80388 1.000 12.89071 ? 1731 ARG A NH2  1 
ATOM   4338 H  H    . ARG A 1 272 ? -7.44367  -18.12309 -20.56264 1.000 10.39035 ? 1731 ARG A H    1 
ATOM   4339 H  HA   . ARG A 1 272 ? -7.85865  -17.52502 -17.98008 1.000 10.56729 ? 1731 ARG A HA   1 
ATOM   4340 H  HB2  . ARG A 1 272 ? -9.32632  -17.01748 -20.32669 1.000 10.57991 ? 1731 ARG A HB2  1 
ATOM   4341 H  HB3  . ARG A 1 272 ? -9.86833  -16.60337 -18.89137 1.000 10.57991 ? 1731 ARG A HB3  1 
ATOM   4342 H  HG2  . ARG A 1 272 ? -8.22518  -15.05049 -18.61246 1.000 11.30003 ? 1731 ARG A HG2  1 
ATOM   4343 H  HG3  . ARG A 1 272 ? -7.36293  -15.64954 -19.80538 1.000 11.30003 ? 1731 ARG A HG3  1 
ATOM   4344 H  HD2  . ARG A 1 272 ? -8.85107  -14.75837 -21.34701 1.000 11.38210 ? 1731 ARG A HD2  1 
ATOM   4345 H  HD3  . ARG A 1 272 ? -9.75039  -14.19112 -20.16597 1.000 11.38210 ? 1731 ARG A HD3  1 
ATOM   4346 H  HE   . ARG A 1 272 ? -8.34163  -12.48050 -20.00475 1.000 11.80537 ? 1731 ARG A HE   1 
ATOM   4347 H  HH11 . ARG A 1 272 ? -6.86500  -14.71328 -21.94945 1.000 14.76142 ? 1731 ARG A HH11 1 
ATOM   4348 H  HH12 . ARG A 1 272 ? -5.61620  -13.93002 -22.16346 1.000 14.76142 ? 1731 ARG A HH12 1 
ATOM   4349 H  HH21 . ARG A 1 272 ? -6.42026  -11.35171 -20.30419 1.000 15.46885 ? 1731 ARG A HH21 1 
ATOM   4350 H  HH22 . ARG A 1 272 ? -5.34719  -11.90680 -21.17550 1.000 15.46885 ? 1731 ARG A HH22 1 
ATOM   4351 N  N    . LEU A 1 273 ? -9.13248  -20.17317 -19.03383 1.000 8.67708  ? 1732 LEU A N    1 
ATOM   4352 C  CA   . LEU A 1 273 ? -9.89833  -21.34391 -18.60184 1.000 8.93243  ? 1732 LEU A CA   1 
ATOM   4353 C  C    . LEU A 1 273 ? -9.00253  -22.53894 -18.27885 1.000 9.96141  ? 1732 LEU A C    1 
ATOM   4354 O  O    . LEU A 1 273 ? -9.51047  -23.63116 -18.02787 1.000 10.20625 ? 1732 LEU A O    1 
ATOM   4355 C  CB   . LEU A 1 273 ? -10.96156 -21.74155 -19.62599 1.000 9.91421  ? 1732 LEU A CB   1 
ATOM   4356 C  CG   . LEU A 1 273 ? -12.25632 -20.95974 -19.53329 1.000 11.57230 ? 1732 LEU A CG   1 
ATOM   4357 C  CD1  . LEU A 1 273 ? -13.19781 -21.31890 -20.66713 1.000 13.70651 ? 1732 LEU A CD1  1 
ATOM   4358 C  CD2  . LEU A 1 273 ? -12.93888 -21.15355 -18.19642 1.000 12.94069 ? 1732 LEU A CD2  1 
ATOM   4359 H  H    . LEU A 1 273 ? -8.70783  -20.28776 -19.77285 1.000 10.41250 ? 1732 LEU A H    1 
ATOM   4360 H  HA   . LEU A 1 273 ? -10.37503 -21.09795 -17.79366 1.000 10.71891 ? 1732 LEU A HA   1 
ATOM   4361 H  HB2  . LEU A 1 273 ? -10.59902 -21.60260 -20.51490 1.000 11.89706 ? 1732 LEU A HB2  1 
ATOM   4362 H  HB3  . LEU A 1 273 ? -11.17607 -22.67884 -19.49797 1.000 11.89706 ? 1732 LEU A HB3  1 
ATOM   4363 H  HG   . LEU A 1 273 ? -12.03485 -20.01865 -19.61192 1.000 13.88676 ? 1732 LEU A HG   1 
ATOM   4364 H  HD11 . LEU A 1 273 ? -13.99845 -20.77582 -20.59683 1.000 16.44781 ? 1732 LEU A HD11 1 
ATOM   4365 H  HD12 . LEU A 1 273 ? -12.75436 -21.14653 -21.51243 1.000 16.44781 ? 1732 LEU A HD12 1 
ATOM   4366 H  HD13 . LEU A 1 273 ? -13.42863 -22.25866 -20.60027 1.000 16.44781 ? 1732 LEU A HD13 1 
ATOM   4367 H  HD21 . LEU A 1 273 ? -13.86867 -20.88863 -18.27521 1.000 15.52883 ? 1732 LEU A HD21 1 
ATOM   4368 H  HD22 . LEU A 1 273 ? -12.88154 -22.08870 -17.94519 1.000 15.52883 ? 1732 LEU A HD22 1 
ATOM   4369 H  HD23 . LEU A 1 273 ? -12.49371 -20.60465 -17.53203 1.000 15.52883 ? 1732 LEU A HD23 1 
ATOM   4370 N  N    . HIS A 1 274 ? -7.67903  -22.34433 -18.17406 1.000 10.09048 ? 1733 HIS A N    1 
ATOM   4371 C  CA   . HIS A 1 274 ? -6.80796  -23.49215 -17.91919 1.000 9.75878  ? 1733 HIS A CA   1 
ATOM   4372 C  C    . HIS A 1 274 ? -5.56606  -23.03107 -17.15068 1.000 8.77449  ? 1733 HIS A C    1 
ATOM   4373 O  O    . HIS A 1 274 ? -5.42915  -23.30227 -15.95735 1.000 9.40083  ? 1733 HIS A O    1 
ATOM   4374 C  CB   . HIS A 1 274 ? -6.45411  -24.23546 -19.21042 1.000 10.39573 ? 1733 HIS A CB   1 
ATOM   4375 C  CG   . HIS A 1 274 ? -5.57680  -25.42022 -19.00343 1.000 10.25634 ? 1733 HIS A CG   1 
ATOM   4376 N  ND1  . HIS A 1 274 ? -6.00792  -26.60302 -18.45094 1.000 10.74314 ? 1733 HIS A ND1  1 
ATOM   4377 C  CD2  . HIS A 1 274 ? -4.24555  -25.60159 -19.25051 1.000 11.03526 ? 1733 HIS A CD2  1 
ATOM   4378 C  CE1  . HIS A 1 274 ? -4.98708  -27.44375 -18.40141 1.000 11.07476 ? 1733 HIS A CE1  1 
ATOM   4379 N  NE2  . HIS A 1 274 ? -3.91681  -26.88462 -18.89911 1.000 11.64319 ? 1733 HIS A NE2  1 
ATOM   4380 H  H    . HIS A 1 274 ? -7.28076  -21.58538 -18.24458 1.000 12.10858 ? 1733 HIS A H    1 
ATOM   4381 H  HA   . HIS A 1 274 ? -7.27498  -24.14258 -17.37171 1.000 11.71054 ? 1733 HIS A HA   1 
ATOM   4382 H  HB2  . HIS A 1 274 ? -7.27409  -24.54417 -19.62662 1.000 12.47488 ? 1733 HIS A HB2  1 
ATOM   4383 H  HB3  . HIS A 1 274 ? -5.99028  -23.62454 -19.80418 1.000 12.47488 ? 1733 HIS A HB3  1 
ATOM   4384 H  HD1  . HIS A 1 274 ? -6.80784  -26.76895 -18.18225 1.000 12.89176 ? 1733 HIS A HD1  1 
ATOM   4385 H  HD2  . HIS A 1 274 ? -3.66327  -24.96465 -19.59714 1.000 13.24232 ? 1733 HIS A HD2  1 
ATOM   4386 H  HE1  . HIS A 1 274 ? -5.02618  -28.30838 -18.06113 1.000 13.28972 ? 1733 HIS A HE1  1 
ATOM   4387 N  N    . HIS A 1 275 ? -4.67205  -22.25242 -17.78167 1.000 8.99296  ? 1734 HIS A N    1 
ATOM   4388 C  CA   . HIS A 1 275 ? -3.38362  -21.96986 -17.13566 1.000 8.41132  ? 1734 HIS A CA   1 
ATOM   4389 C  C    . HIS A 1 275 ? -3.50445  -21.07074 -15.92471 1.000 8.44023  ? 1734 HIS A C    1 
ATOM   4390 O  O    . HIS A 1 275 ? -2.85392  -21.31652 -14.90238 1.000 9.83251  ? 1734 HIS A O    1 
ATOM   4391 C  CB   . HIS A 1 275 ? -2.40890  -21.38243 -18.15731 1.000 9.15087  ? 1734 HIS A CB   1 
ATOM   4392 C  CG   . HIS A 1 275 ? -1.96197  -22.33209 -19.20858 1.000 10.26674 ? 1734 HIS A CG   1 
ATOM   4393 N  ND1  . HIS A 1 275 ? -1.14616  -23.38700 -18.91344 1.000 10.68794 ? 1734 HIS A ND1  1 
ATOM   4394 C  CD2  . HIS A 1 275 ? -2.18953  -22.37863 -20.53155 1.000 11.39060 ? 1734 HIS A CD2  1 
ATOM   4395 C  CE1  . HIS A 1 275 ? -0.90261  -24.05856 -20.02258 1.000 11.99853 ? 1734 HIS A CE1  1 
ATOM   4396 N  NE2  . HIS A 1 275 ? -1.49456  -23.45047 -21.03346 1.000 12.49064 ? 1734 HIS A NE2  1 
ATOM   4397 H  H    . HIS A 1 275 ? -4.78388  -21.89045 -18.55373 1.000 10.79155 ? 1734 HIS A H    1 
ATOM   4398 H  HA   . HIS A 1 275 ? -3.02880  -22.81284 -16.81256 1.000 10.09358 ? 1734 HIS A HA   1 
ATOM   4399 H  HB2  . HIS A 1 275 ? -2.84147  -20.63698 -18.60238 1.000 10.98105 ? 1734 HIS A HB2  1 
ATOM   4400 H  HB3  . HIS A 1 275 ? -1.61833  -21.07460 -17.68705 1.000 10.98105 ? 1734 HIS A HB3  1 
ATOM   4401 H  HD1  . HIS A 1 275 ? -0.84143  -23.58144 -18.13310 1.000 12.82553 ? 1734 HIS A HD1  1 
ATOM   4402 H  HD2  . HIS A 1 275 ? -2.72123  -21.79144 -21.01878 1.000 13.66872 ? 1734 HIS A HD2  1 
ATOM   4403 H  HE1  . HIS A 1 275 ? -0.39527  -24.83568 -20.08253 1.000 14.39824 ? 1734 HIS A HE1  1 
ATOM   4404 N  N    . ASN A 1 276 ? -4.28358  -19.99163 -16.03963 1.000 8.70873  ? 1735 ASN A N    1 
ATOM   4405 C  CA   . ASN A 1 276 ? -4.39031  -19.08155 -14.91685 1.000 9.41930  ? 1735 ASN A CA   1 
ATOM   4406 C  C    . ASN A 1 276 ? -5.18786  -19.61755 -13.72996 1.000 8.71133  ? 1735 ASN A C    1 
ATOM   4407 O  O    . ASN A 1 276 ? -4.74930  -19.50829 -12.59272 1.000 8.89556  ? 1735 ASN A O    1 
ATOM   4408 C  CB   . ASN A 1 276 ? -4.86958  -17.67087 -15.30554 1.000 9.57723  ? 1735 ASN A CB   1 
ATOM   4409 C  CG   . ASN A 1 276 ? -3.85649  -16.94511 -16.20820 1.000 10.34048 ? 1735 ASN A CG   1 
ATOM   4410 O  OD1  . ASN A 1 276 ? -2.63530  -17.16878 -16.07560 1.000 11.25897 ? 1735 ASN A OD1  1 
ATOM   4411 N  ND2  . ASN A 1 276 ? -4.31629  -16.03326 -17.01010 1.000 9.98250  ? 1735 ASN A ND2  1 
ATOM   4412 H  H    . ASN A 1 276 ? -4.74100  -19.77932 -16.73626 1.000 10.45048 ? 1735 ASN A H    1 
ATOM   4413 H  HA   . ASN A 1 276 ? -3.47640  -19.00311 -14.60140 1.000 11.30316 ? 1735 ASN A HA   1 
ATOM   4414 H  HB2  . ASN A 1 276 ? -5.70877  -17.74062 -15.78699 1.000 11.49268 ? 1735 ASN A HB2  1 
ATOM   4415 H  HB3  . ASN A 1 276 ? -4.99149  -17.14264 -14.50117 1.000 11.49268 ? 1735 ASN A HB3  1 
ATOM   4416 H  HD21 . ASN A 1 276 ? -5.15768  -15.85574 -17.02205 1.000 11.97901 ? 1735 ASN A HD21 1 
ATOM   4417 H  HD22 . ASN A 1 276 ? -3.77944  -15.60682 -17.52927 1.000 11.97901 ? 1735 ASN A HD22 1 
ATOM   4418 N  N    . PRO A 1 277 ? -6.28650  -20.36860 -13.97083 1.000 9.37196  ? 1736 PRO A N    1 
ATOM   4419 C  CA   . PRO A 1 277 ? -6.91334  -21.10487 -12.85857 1.000 10.82200 ? 1736 PRO A CA   1 
ATOM   4420 C  C    . PRO A 1 277 ? -5.93913  -22.00783 -12.14745 1.000 9.60096  ? 1736 PRO A C    1 
ATOM   4421 O  O    . PRO A 1 277 ? -5.89599  -22.01062 -10.92618 1.000 10.10358 ? 1736 PRO A O    1 
ATOM   4422 C  CB   . PRO A 1 277 ? -8.02781  -21.87567 -13.53168 1.000 11.18256 ? 1736 PRO A CB   1 
ATOM   4423 C  CG   . PRO A 1 277 ? -8.43476  -20.99720 -14.68535 1.000 10.91687 ? 1736 PRO A CG   1 
ATOM   4424 C  CD   . PRO A 1 277 ? -7.10089  -20.35971 -15.19392 1.000 9.76942  ? 1736 PRO A CD   1 
ATOM   4425 H  HA   . PRO A 1 277 ? -7.30799  -20.48191 -12.22843 1.000 12.98640 ? 1736 PRO A HA   1 
ATOM   4426 H  HB2  . PRO A 1 277 ? -7.69972  -22.73374 -13.84308 1.000 13.41907 ? 1736 PRO A HB2  1 
ATOM   4427 H  HB3  . PRO A 1 277 ? -8.76405  -22.00637 -12.91380 1.000 13.41907 ? 1736 PRO A HB3  1 
ATOM   4428 H  HG2  . PRO A 1 277 ? -8.85013  -21.53296 -15.37912 1.000 13.10025 ? 1736 PRO A HG2  1 
ATOM   4429 H  HG3  . PRO A 1 277 ? -9.05172  -20.31391 -14.37977 1.000 13.10025 ? 1736 PRO A HG3  1 
ATOM   4430 H  HD2  . PRO A 1 277 ? -6.69581  -20.89980 -15.89043 1.000 11.72330 ? 1736 PRO A HD2  1 
ATOM   4431 H  HD3  . PRO A 1 277 ? -7.24305  -19.45570 -15.51556 1.000 11.72330 ? 1736 PRO A HD3  1 
ATOM   4432 N  N    . ARG A 1 278 ? -5.13167  -22.77852 -12.90982 1.000 9.86676  ? 1737 ARG A N    1 
ATOM   4433 C  CA   . ARG A 1 278 ? -4.14922  -23.64494 -12.27539 1.000 10.54315 ? 1737 ARG A CA   1 
ATOM   4434 C  C    . ARG A 1 278 ? -3.24044  -22.85378 -11.34143 1.000 9.40886  ? 1737 ARG A C    1 
ATOM   4435 O  O    . ARG A 1 278 ? -2.94556  -23.28765 -10.22271 1.000 10.49570 ? 1737 ARG A O    1 
ATOM   4436 C  CB   . ARG A 1 278 ? -3.27249  -24.31963 -13.34503 1.000 11.99060 ? 1737 ARG A CB   1 
ATOM   4437 C  CG   . ARG A 1 278 ? -3.69730  -25.60424 -13.93831 1.000 12.32757 ? 1737 ARG A CG   1 
ATOM   4438 C  CD   . ARG A 1 278 ? -2.57366  -26.09469 -14.85956 1.000 13.55932 ? 1737 ARG A CD   1 
ATOM   4439 N  NE   . ARG A 1 278 ? -2.92242  -27.35549 -15.48340 1.000 14.23035 ? 1737 ARG A NE   1 
ATOM   4440 C  CZ   . ARG A 1 278 ? -2.19090  -27.84436 -16.44363 1.000 14.01714 ? 1737 ARG A CZ   1 
ATOM   4441 N  NH1  . ARG A 1 278 ? -1.13359  -27.18463 -16.92256 1.000 12.21706 ? 1737 ARG A NH1  1 
ATOM   4442 N  NH2  . ARG A 1 278 ? -2.47608  -29.05032 -16.92346 1.000 14.89891 ? 1737 ARG A NH2  1 
ATOM   4443 H  H    . ARG A 1 278 ? -5.14206  -22.80828 -13.76924 1.000 11.84011 ? 1737 ARG A H    1 
ATOM   4444 H  HA   . ARG A 1 278 ? -4.62762  -24.32140 -11.77098 1.000 12.65178 ? 1737 ARG A HA   1 
ATOM   4445 H  HB2  . ARG A 1 278 ? -3.18764  -23.69621 -14.08330 1.000 14.38872 ? 1737 ARG A HB2  1 
ATOM   4446 H  HB3  . ARG A 1 278 ? -2.40344  -24.48101 -12.94552 1.000 14.38872 ? 1737 ARG A HB3  1 
ATOM   4447 H  HG2  . ARG A 1 278 ? -3.84833  -26.26123 -13.24086 1.000 14.79308 ? 1737 ARG A HG2  1 
ATOM   4448 H  HG3  . ARG A 1 278 ? -4.50645  -25.48106 -14.45890 1.000 14.79308 ? 1737 ARG A HG3  1 
ATOM   4449 H  HD2  . ARG A 1 278 ? -2.41993  -25.43923 -15.55788 1.000 16.27118 ? 1737 ARG A HD2  1 
ATOM   4450 H  HD3  . ARG A 1 278 ? -1.76411  -26.22284 -14.34080 1.000 16.27118 ? 1737 ARG A HD3  1 
ATOM   4451 H  HE   . ARG A 1 278 ? -3.61855  -27.78460 -15.21716 1.000 17.07642 ? 1737 ARG A HE   1 
ATOM   4452 H  HH11 . ARG A 1 278 ? -0.92147  -26.41764 -16.59645 1.000 14.66048 ? 1737 ARG A HH11 1 
ATOM   4453 H  HH12 . ARG A 1 278 ? -0.66466  -27.52665 -17.55716 1.000 14.66048 ? 1737 ARG A HH12 1 
ATOM   4454 H  HH21 . ARG A 1 278 ? -3.13608  -29.49680 -16.59996 1.000 17.87870 ? 1737 ARG A HH21 1 
ATOM   4455 H  HH22 . ARG A 1 278 ? -2.00062  -29.38431 -17.55750 1.000 17.87870 ? 1737 ARG A HH22 1 
ATOM   4456 N  N    . ARG A 1 279 ? -2.69100  -21.72358 -11.83563 1.000 9.42195  ? 1738 ARG A N    1 
ATOM   4457 C  CA   . ARG A 1 279 ? -1.60874  -21.08312 -11.10484 1.000 9.08768  ? 1738 ARG A CA   1 
ATOM   4458 C  C    . ARG A 1 279 ? -2.09864  -20.24053 -9.95560  1.000 9.00347  ? 1738 ARG A C    1 
ATOM   4459 O  O    . ARG A 1 279 ? -1.37754  -20.09683 -8.95255  1.000 10.25619 ? 1738 ARG A O    1 
ATOM   4460 C  CB   . ARG A 1 279 ? -0.72803  -20.26472 -12.05540 1.000 9.53516  ? 1738 ARG A CB   1 
ATOM   4461 C  CG   . ARG A 1 279 ? -1.24569  -18.91784 -12.43658 1.000 9.99575  ? 1738 ARG A CG   1 
ATOM   4462 C  CD   . ARG A 1 279 ? -0.48374  -18.40681 -13.67285 1.000 12.82753 ? 1738 ARG A CD   1 
ATOM   4463 N  NE   . ARG A 1 279 ? -0.69078  -17.01227 -14.00041 1.000 14.09885 ? 1738 ARG A NE   1 
ATOM   4464 C  CZ   . ARG A 1 279 ? -0.27121  -15.97979 -13.27971 1.000 18.32558 ? 1738 ARG A CZ   1 
ATOM   4465 N  NH1  . ARG A 1 279 ? 0.61521   -16.13504 -12.29640 1.000 17.34139 ? 1738 ARG A NH1  1 
ATOM   4466 N  NH2  . ARG A 1 279 ? -0.60524  -14.73451 -13.65678 1.000 21.92068 ? 1738 ARG A NH2  1 
ATOM   4467 H  H    . ARG A 1 279 ? -2.92634  -21.33250 -12.56451 1.000 11.30634 ? 1738 ARG A H    1 
ATOM   4468 H  HA   . ARG A 1 279 ? -1.04762  -21.77633 -10.72339 1.000 10.90522 ? 1738 ARG A HA   1 
ATOM   4469 H  HB2  . ARG A 1 279 ? 0.13287   -20.12992 -11.62928 1.000 11.44219 ? 1738 ARG A HB2  1 
ATOM   4470 H  HB3  . ARG A 1 279 ? -0.61670  -20.77069 -12.87546 1.000 11.44219 ? 1738 ARG A HB3  1 
ATOM   4471 H  HG2  . ARG A 1 279 ? -2.18951  -18.97705 -12.65245 1.000 11.99490 ? 1738 ARG A HG2  1 
ATOM   4472 H  HG3  . ARG A 1 279 ? -1.11102  -18.29457 -11.70562 1.000 11.99490 ? 1738 ARG A HG3  1 
ATOM   4473 H  HD2  . ARG A 1 279 ? 0.46612   -18.52829 -13.51822 1.000 15.39303 ? 1738 ARG A HD2  1 
ATOM   4474 H  HD3  . ARG A 1 279 ? -0.76403  -18.92780 -14.44155 1.000 15.39303 ? 1738 ARG A HD3  1 
ATOM   4475 H  HE   . ARG A 1 279 ? -1.12238  -16.83786 -14.72353 1.000 16.91862 ? 1738 ARG A HE   1 
ATOM   4476 H  HH11 . ARG A 1 279 ? 0.92716   -16.91637 -12.11808 1.000 20.80967 ? 1738 ARG A HH11 1 
ATOM   4477 H  HH12 . ARG A 1 279 ? 0.87517   -15.45386 -11.84030 1.000 20.80967 ? 1738 ARG A HH12 1 
ATOM   4478 H  HH21 . ARG A 1 279 ? -1.08642  -14.61237 -14.35903 1.000 26.30482 ? 1738 ARG A HH21 1 
ATOM   4479 H  HH22 . ARG A 1 279 ? -0.33790  -14.05940 -13.19595 1.000 26.30482 ? 1738 ARG A HH22 1 
ATOM   4480 N  N    . ILE A 1 280 ? -3.31065  -19.68702 -10.06859 1.000 9.11410  ? 1739 ILE A N    1 
ATOM   4481 C  CA   . ILE A 1 280 ? -3.81784  -18.85967 -8.98184  1.000 9.95881  ? 1739 ILE A CA   1 
ATOM   4482 C  C    . ILE A 1 280 ? -4.27338  -19.70423 -7.81797  1.000 10.66153 ? 1739 ILE A C    1 
ATOM   4483 O  O    . ILE A 1 280 ? -4.09242  -19.34705 -6.66948  1.000 12.09324 ? 1739 ILE A O    1 
ATOM   4484 C  CB   . ILE A 1 280 ? -4.95645  -17.98641 -9.51625  1.000 10.14321 ? 1739 ILE A CB   1 
ATOM   4485 C  CG1  . ILE A 1 280 ? -4.40969  -16.92668 -10.48424 1.000 10.54049 ? 1739 ILE A CG1  1 
ATOM   4486 C  CG2  . ILE A 1 280 ? -5.70915  -17.31279 -8.38274  1.000 12.07743 ? 1739 ILE A CG2  1 
ATOM   4487 C  CD1  . ILE A 1 280 ? -5.48908  -16.28551 -11.34714 1.000 12.28277 ? 1739 ILE A CD1  1 
ATOM   4488 H  H    . ILE A 1 280 ? -3.83770  -19.77452 -10.74250 1.000 10.93692 ? 1739 ILE A H    1 
ATOM   4489 H  HA   . ILE A 1 280 ? -3.10199  -18.29007 -8.65932  1.000 11.95057 ? 1739 ILE A HA   1 
ATOM   4490 H  HB   . ILE A 1 280 ? -5.57214  -18.56507 -9.99268  1.000 12.17185 ? 1739 ILE A HB   1 
ATOM   4491 H  HG12 . ILE A 1 280 ? -3.98186  -16.22368 -9.97077  1.000 12.64859 ? 1739 ILE A HG12 1 
ATOM   4492 H  HG13 . ILE A 1 280 ? -3.76464  -17.34502 -11.07569 1.000 12.64859 ? 1739 ILE A HG13 1 
ATOM   4493 H  HG21 . ILE A 1 280 ? -6.23659  -16.58309 -8.74363  1.000 14.49292 ? 1739 ILE A HG21 1 
ATOM   4494 H  HG22 . ILE A 1 280 ? -6.29073  -17.96344 -7.95927  1.000 14.49292 ? 1739 ILE A HG22 1 
ATOM   4495 H  HG23 . ILE A 1 280 ? -5.06982  -16.97151 -7.73801  1.000 14.49292 ? 1739 ILE A HG23 1 
ATOM   4496 H  HD11 . ILE A 1 280 ? -5.06609  -15.73709 -12.02627 1.000 14.73932 ? 1739 ILE A HD11 1 
ATOM   4497 H  HD12 . ILE A 1 280 ? -6.01472  -16.98456 -11.76658 1.000 14.73932 ? 1739 ILE A HD12 1 
ATOM   4498 H  HD13 . ILE A 1 280 ? -6.05769  -15.73614 -10.78520 1.000 14.73932 ? 1739 ILE A HD13 1 
ATOM   4499 N  N    . PHE A 1 281 ? -4.86199  -20.87469 -8.11964  1.000 10.30896 ? 1740 PHE A N    1 
ATOM   4500 C  CA   . PHE A 1 281 ? -5.39850  -21.75586 -7.09133  1.000 10.57733 ? 1740 PHE A CA   1 
ATOM   4501 C  C    . PHE A 1 281 ? -4.51768  -22.95020 -6.81781  1.000 11.12210 ? 1740 PHE A C    1 
ATOM   4502 O  O    . PHE A 1 281 ? -4.85325  -23.76862 -5.96890  1.000 11.96957 ? 1740 PHE A O    1 
ATOM   4503 C  CB   . PHE A 1 281 ? -6.81071  -22.20387 -7.49143  1.000 10.36941 ? 1740 PHE A CB   1 
ATOM   4504 C  CG   . PHE A 1 281 ? -7.78332  -21.03384 -7.50985  1.000 9.24047  ? 1740 PHE A CG   1 
ATOM   4505 C  CD1  . PHE A 1 281 ? -8.46734  -20.70643 -6.37741  1.000 10.44312 ? 1740 PHE A CD1  1 
ATOM   4506 C  CD2  . PHE A 1 281 ? -7.95181  -20.27886 -8.67211  1.000 9.95357  ? 1740 PHE A CD2  1 
ATOM   4507 C  CE1  . PHE A 1 281 ? -9.32350  -19.61271 -6.38497  1.000 12.05112 ? 1740 PHE A CE1  1 
ATOM   4508 C  CE2  . PHE A 1 281 ? -8.80446  -19.17326 -8.68455  1.000 9.81414  ? 1740 PHE A CE2  1 
ATOM   4509 C  CZ   . PHE A 1 281 ? -9.47767  -18.85839 -7.53704  1.000 11.29838 ? 1740 PHE A CZ   1 
ATOM   4510 H  H    . PHE A 1 281 ? -4.95853  -21.17367 -8.92020  1.000 12.37075 ? 1740 PHE A H    1 
ATOM   4511 H  HA   . PHE A 1 281 ? -5.46984  -21.26749 -6.25628  1.000 12.69279 ? 1740 PHE A HA   1 
ATOM   4512 H  HB2  . PHE A 1 281 ? -6.78392  -22.59289 -8.37960  1.000 12.44329 ? 1740 PHE A HB2  1 
ATOM   4513 H  HB3  . PHE A 1 281 ? -7.13243  -22.85855 -6.85205  1.000 12.44329 ? 1740 PHE A HB3  1 
ATOM   4514 H  HD1  . PHE A 1 281 ? -8.36148  -21.21228 -5.60423  1.000 12.53175 ? 1740 PHE A HD1  1 
ATOM   4515 H  HD2  . PHE A 1 281 ? -7.49183  -20.51457 -9.44526  1.000 11.94429 ? 1740 PHE A HD2  1 
ATOM   4516 H  HE1  . PHE A 1 281 ? -9.79411  -19.38629 -5.61545  1.000 14.46135 ? 1740 PHE A HE1  1 
ATOM   4517 H  HE2  . PHE A 1 281 ? -8.91184  -18.66333 -9.45484  1.000 11.77697 ? 1740 PHE A HE2  1 
ATOM   4518 H  HZ   . PHE A 1 281 ? -10.04929 -18.12484 -7.52955  1.000 13.55806 ? 1740 PHE A HZ   1 
ATOM   4519 N  N    A HIS A 1 282 ? -3.35852  -23.01080 -7.44366  0.617 10.24577 ? 1741 HIS A N    1 
ATOM   4520 N  N    B HIS A 1 282 ? -3.36634  -23.05223 -7.46333  0.383 10.81687 ? 1741 HIS A N    1 
ATOM   4521 C  CA   A HIS A 1 282 ? -2.45567  -24.16234 -7.31529  0.617 10.38527 ? 1741 HIS A CA   1 
ATOM   4522 C  CA   B HIS A 1 282 ? -2.47509  -24.20649 -7.27916  0.383 11.20638 ? 1741 HIS A CA   1 
ATOM   4523 C  C    A HIS A 1 282 ? -3.23713  -25.47065 -7.47521  0.617 10.20627 ? 1741 HIS A C    1 
ATOM   4524 C  C    B HIS A 1 282 ? -3.23415  -25.51354 -7.49710  0.383 10.87475 ? 1741 HIS A C    1 
ATOM   4525 O  O    A HIS A 1 282 ? -3.19309  -26.37470 -6.61554  0.617 12.25641 ? 1741 HIS A O    1 
ATOM   4526 O  O    B HIS A 1 282 ? -3.17337  -26.45309 -6.68774  0.383 12.18801 ? 1741 HIS A O    1 
ATOM   4527 C  CB   A HIS A 1 282 ? -1.65637  -24.10399 -6.00924  0.617 11.43787 ? 1741 HIS A CB   1 
ATOM   4528 C  CB   B HIS A 1 282 ? -1.82164  -24.18140 -5.90302  0.383 12.01168 ? 1741 HIS A CB   1 
ATOM   4529 C  CG   A HIS A 1 282 ? -0.64209  -22.97784 -5.98224  0.617 10.43277 ? 1741 HIS A CG   1 
ATOM   4530 C  CG   B HIS A 1 282 ? -1.62834  -22.79262 -5.37584  0.383 11.75649 ? 1741 HIS A CG   1 
ATOM   4531 N  ND1  A HIS A 1 282 ? 0.51128   -23.00267 -6.74417  0.617 12.87486 ? 1741 HIS A ND1  1 
ATOM   4532 N  ND1  B HIS A 1 282 ? -0.53542  -22.01228 -5.72237  0.383 13.00125 ? 1741 HIS A ND1  1 
ATOM   4533 C  CD2  A HIS A 1 282 ? -0.61615  -21.79242 -5.30703  0.617 11.83538 ? 1741 HIS A CD2  1 
ATOM   4534 C  CD2  B HIS A 1 282 ? -2.38266  -22.04002 -4.54281  0.383 12.49335 ? 1741 HIS A CD2  1 
ATOM   4535 C  CE1  A HIS A 1 282 ? 1.17703   -21.87824 -6.54566  0.617 12.38811 ? 1741 HIS A CE1  1 
ATOM   4536 C  CE1  B HIS A 1 282 ? -0.64561  -20.84315 -5.13098  0.383 13.35132 ? 1741 HIS A CE1  1 
ATOM   4537 N  NE2  A HIS A 1 282 ? 0.54012   -21.15636 -5.65301  0.617 13.51973 ? 1741 HIS A NE2  1 
ATOM   4538 N  NE2  B HIS A 1 282 ? -1.73709  -20.84027 -4.39690  0.383 12.81976 ? 1741 HIS A NE2  1 
ATOM   4539 H  H    A HIS A 1 282 ? -3.05798  -22.39199 -7.95975  0.617 12.29493 ? 1741 HIS A H    1 
ATOM   4540 H  H    B HIS A 1 282 ? -3.07004  -22.46632 -8.01878  0.383 12.98024 ? 1741 HIS A H    1 
ATOM   4541 H  HA   A HIS A 1 282 ? -1.80181  -24.13434 -8.03124  0.617 12.46232 ? 1741 HIS A HA   1 
ATOM   4542 H  HA   B HIS A 1 282 ? -1.76974  -24.15614 -7.94313  0.383 13.44766 ? 1741 HIS A HA   1 
ATOM   4543 H  HB2  A HIS A 1 282 ? -2.27061  -23.97067 -5.27043  0.617 13.72544 ? 1741 HIS A HB2  1 
ATOM   4544 H  HB2  B HIS A 1 282 ? -2.38476  -24.66384 -5.27769  0.383 14.41401 ? 1741 HIS A HB2  1 
ATOM   4545 H  HB3  A HIS A 1 282 ? -1.17769  -24.94002 -5.89599  0.617 13.72544 ? 1741 HIS A HB3  1 
ATOM   4546 H  HB3  B HIS A 1 282 ? -0.95064  -24.60454 -5.95975  0.383 14.41401 ? 1741 HIS A HB3  1 
ATOM   4547 H  HD2  A HIS A 1 282 ? -1.26536  -21.47700 -4.72057  0.617 14.20246 ? 1741 HIS A HD2  1 
ATOM   4548 H  HD2  B HIS A 1 282 ? -3.18564  -22.28911 -4.14523  0.383 14.99202 ? 1741 HIS A HD2  1 
ATOM   4549 H  HE1  A HIS A 1 282 ? 1.96882   -21.63732 -6.96985  0.617 14.86574 ? 1741 HIS A HE1  1 
ATOM   4550 H  HE1  B HIS A 1 282 ? -0.04961  -20.13448 -5.21750  0.383 16.02159 ? 1741 HIS A HE1  1 
ATOM   4551 H  HE2  B HIS A 1 282 ? -2.00345  -20.18832 -3.90332  0.383 15.38372 ? 1741 HIS A HE2  1 
ATOM   4552 N  N    . LEU A 1 283 ? -3.93846  -25.57033 -8.61527  1.000 10.48264 ? 1742 LEU A N    1 
ATOM   4553 C  CA   . LEU A 1 283 ? -4.70654  -26.75829 -8.91231  1.000 10.94060 ? 1742 LEU A CA   1 
ATOM   4554 C  C    . LEU A 1 283 ? -3.85932  -27.67420 -9.78909  1.000 12.18281 ? 1742 LEU A C    1 
ATOM   4555 O  O    . LEU A 1 283 ? -3.13393  -27.17659 -10.67406 1.000 13.83818 ? 1742 LEU A O    1 
ATOM   4556 C  CB   . LEU A 1 283 ? -6.01465  -26.41433 -9.62923  1.000 11.99852 ? 1742 LEU A CB   1 
ATOM   4557 C  CG   . LEU A 1 283 ? -6.99438  -25.60287 -8.81420  1.000 11.56696 ? 1742 LEU A CG   1 
ATOM   4558 C  CD1  . LEU A 1 283 ? -8.10600  -24.99479 -9.67844  1.000 11.90643 ? 1742 LEU A CD1  1 
ATOM   4559 C  CD2  . LEU A 1 283 ? -7.59455  -26.41837 -7.71257  1.000 11.47744 ? 1742 LEU A CD2  1 
ATOM   4560 H  H    . LEU A 1 283 ? -3.97503  -24.95872 -9.21876  1.000 12.57917 ? 1742 LEU A H    1 
ATOM   4561 H  HA   . LEU A 1 283 ? -4.94974  -27.21957 -8.09440  1.000 13.12873 ? 1742 LEU A HA   1 
ATOM   4562 H  HB2  . LEU A 1 283 ? -5.80238  -25.90178 -10.42493 1.000 14.39823 ? 1742 LEU A HB2  1 
ATOM   4563 H  HB3  . LEU A 1 283 ? -6.45581  -27.24226 -9.87580  1.000 14.39823 ? 1742 LEU A HB3  1 
ATOM   4564 H  HG   . LEU A 1 283 ? -6.49545  -24.87047 -8.41979  1.000 13.88035 ? 1742 LEU A HG   1 
ATOM   4565 H  HD11 . LEU A 1 283 ? -8.70302  -24.48278 -9.11071  1.000 14.28771 ? 1742 LEU A HD11 1 
ATOM   4566 H  HD12 . LEU A 1 283 ? -7.70603  -24.41531 -10.34561 1.000 14.28771 ? 1742 LEU A HD12 1 
ATOM   4567 H  HD13 . LEU A 1 283 ? -8.59560  -25.71068 -10.11283 1.000 14.28771 ? 1742 LEU A HD13 1 
ATOM   4568 H  HD21 . LEU A 1 283 ? -8.26143  -25.88519 -7.25226  1.000 13.77292 ? 1742 LEU A HD21 1 
ATOM   4569 H  HD22 . LEU A 1 283 ? -8.00834  -27.20845 -8.09394  1.000 13.77292 ? 1742 LEU A HD22 1 
ATOM   4570 H  HD23 . LEU A 1 283 ? -6.89388  -26.67782 -7.09398  1.000 13.77292 ? 1742 LEU A HD23 1 
ATOM   4571 N  N    . PRO A 1 284 ? -3.88462  -28.97647 -9.52264  1.000 11.32483 ? 1743 PRO A N    1 
ATOM   4572 C  CA   . PRO A 1 284 ? -2.95382  -29.88219 -10.19127 1.000 10.96168 ? 1743 PRO A CA   1 
ATOM   4573 C  C    . PRO A 1 284 ? -3.36784  -30.17941 -11.61641 1.000 10.93270 ? 1743 PRO A C    1 
ATOM   4574 O  O    . PRO A 1 284 ? -4.55455  -30.07314 -11.97869 1.000 11.61951 ? 1743 PRO A O    1 
ATOM   4575 C  CB   . PRO A 1 284 ? -3.01796  -31.12986 -9.32444  1.000 12.01958 ? 1743 PRO A CB   1 
ATOM   4576 C  CG   . PRO A 1 284 ? -4.45464  -31.14007 -8.86455  1.000 12.51174 ? 1743 PRO A CG   1 
ATOM   4577 C  CD   . PRO A 1 284 ? -4.74184  -29.66512 -8.56008  1.000 12.22751 ? 1743 PRO A CD   1 
ATOM   4578 H  HA   . PRO A 1 284 ? -2.05734  -29.51176 -10.19360 1.000 13.15402 ? 1743 PRO A HA   1 
ATOM   4579 H  HB2  . PRO A 1 284 ? -2.80675  -31.91842 -9.84832  1.000 14.42350 ? 1743 PRO A HB2  1 
ATOM   4580 H  HB3  . PRO A 1 284 ? -2.40558  -31.05503 -8.57591  1.000 14.42350 ? 1743 PRO A HB3  1 
ATOM   4581 H  HG2  . PRO A 1 284 ? -5.03169  -31.47316 -9.56951  1.000 15.01408 ? 1743 PRO A HG2  1 
ATOM   4582 H  HG3  . PRO A 1 284 ? -4.55030  -31.68886 -8.07046  1.000 15.01408 ? 1743 PRO A HG3  1 
ATOM   4583 H  HD2  . PRO A 1 284 ? -5.67634  -29.45313 -8.71066  1.000 14.67301 ? 1743 PRO A HD2  1 
ATOM   4584 H  HD3  . PRO A 1 284 ? -4.49360  -29.44192 -7.64933  1.000 14.67301 ? 1743 PRO A HD3  1 
ATOM   4585 N  N    . PRO A 1 285 ? -2.43951  -30.66958 -12.43324 1.000 10.97742 ? 1744 PRO A N    1 
ATOM   4586 C  CA   . PRO A 1 285 ? -2.79492  -31.19897 -13.75690 1.000 10.92226 ? 1744 PRO A CA   1 
ATOM   4587 C  C    . PRO A 1 285 ? -3.70994  -32.39990 -13.60677 1.000 11.65644 ? 1744 PRO A C    1 
ATOM   4588 O  O    . PRO A 1 285 ? -3.68777  -33.10531 -12.59239 1.000 12.44593 ? 1744 PRO A O    1 
ATOM   4589 C  CB   . PRO A 1 285 ? -1.45763  -31.64250 -14.36542 1.000 12.81181 ? 1744 PRO A CB   1 
ATOM   4590 C  CG   . PRO A 1 285 ? -0.43835  -30.95702 -13.48329 1.000 14.01967 ? 1744 PRO A CG   1 
ATOM   4591 C  CD   . PRO A 1 285 ? -0.99590  -30.81927 -12.15123 1.000 11.98540 ? 1744 PRO A CD   1 
ATOM   4592 H  HA   . PRO A 1 285 ? -3.19264  -30.50644 -14.30747 1.000 13.10671 ? 1744 PRO A HA   1 
ATOM   4593 H  HB2  . PRO A 1 285 ? -1.37057  -32.60768 -14.32350 1.000 15.37417 ? 1744 PRO A HB2  1 
ATOM   4594 H  HB3  . PRO A 1 285 ? -1.38875  -31.34282 -15.28539 1.000 15.37417 ? 1744 PRO A HB3  1 
ATOM   4595 H  HG2  . PRO A 1 285 ? 0.36701   -31.49682 -13.45324 1.000 16.82360 ? 1744 PRO A HG2  1 
ATOM   4596 H  HG3  . PRO A 1 285 ? -0.23817  -30.08278 -13.85278 1.000 16.82360 ? 1744 PRO A HG3  1 
ATOM   4597 H  HD2  . PRO A 1 285 ? -0.82416  -31.61028 -11.61670 1.000 14.38248 ? 1744 PRO A HD2  1 
ATOM   4598 H  HD3  . PRO A 1 285 ? -0.64361  -30.03383 -11.70415 1.000 14.38248 ? 1744 PRO A HD3  1 
ATOM   4599 N  N    . GLN A 1 286 ? -4.45181  -32.69155 -14.66952 1.000 11.84597 ? 1745 GLN A N    1 
ATOM   4600 C  CA   . GLN A 1 286 ? -5.22199  -33.92670 -14.78272 1.000 12.01959 ? 1745 GLN A CA   1 
ATOM   4601 C  C    . GLN A 1 286 ? -4.57617  -34.72897 -15.88616 1.000 12.61976 ? 1745 GLN A C    1 
ATOM   4602 O  O    . GLN A 1 286 ? -4.56228  -34.32966 -17.03998 1.000 13.54607 ? 1745 GLN A O    1 
ATOM   4603 C  CB   . GLN A 1 286 ? -6.69322  -33.59980 -15.09593 1.000 12.22486 ? 1745 GLN A CB   1 
ATOM   4604 C  CG   . GLN A 1 286 ? -7.35732  -32.79297 -14.00040 1.000 12.24594 ? 1745 GLN A CG   1 
ATOM   4605 C  CD   . GLN A 1 286 ? -8.75122  -32.35722 -14.36202 1.000 11.58014 ? 1745 GLN A CD   1 
ATOM   4606 O  OE1  . GLN A 1 286 ? -8.90479  -31.44774 -15.16529 1.000 11.17213 ? 1745 GLN A OE1  1 
ATOM   4607 N  NE2  . GLN A 1 286 ? -9.76776  -32.98669 -13.80830 1.000 11.37216 ? 1745 GLN A NE2  1 
ATOM   4608 H  H    . GLN A 1 286 ? -4.52702  -32.17731 -15.35472 1.000 14.21517 ? 1745 GLN A H    1 
ATOM   4609 H  HA   . GLN A 1 286 ? -5.20719  -34.44658 -13.96394 1.000 14.42350 ? 1745 GLN A HA   1 
ATOM   4610 H  HB2  . GLN A 1 286 ? -6.73464  -33.08420 -15.91650 1.000 14.66984 ? 1745 GLN A HB2  1 
ATOM   4611 H  HB3  . GLN A 1 286 ? -7.18599  -34.42883 -15.19980 1.000 14.66984 ? 1745 GLN A HB3  1 
ATOM   4612 H  HG2  . GLN A 1 286 ? -7.41117  -33.33446 -13.19741 1.000 14.69513 ? 1745 GLN A HG2  1 
ATOM   4613 H  HG3  . GLN A 1 286 ? -6.82928  -31.99748 -13.82932 1.000 14.69513 ? 1745 GLN A HG3  1 
ATOM   4614 H  HE21 . GLN A 1 286 ? -9.62567  -33.62955 -13.25501 1.000 13.64659 ? 1745 GLN A HE21 1 
ATOM   4615 H  HE22 . GLN A 1 286 ? -10.57333 -32.75467 -14.00020 1.000 13.64659 ? 1745 GLN A HE22 1 
ATOM   4616 N  N    A GLU A 1 287 ? -4.05355  -35.89573 -15.52747 0.443 13.09875 ? 1746 GLU A N    1 
ATOM   4617 N  N    B GLU A 1 287 ? -4.04035  -35.88834 -15.52578 0.557 12.49606 ? 1746 GLU A N    1 
ATOM   4618 C  CA   A GLU A 1 287 ? -3.41537  -36.76534 -16.50049 0.443 14.79363 ? 1746 GLU A CA   1 
ATOM   4619 C  CA   B GLU A 1 287 ? -3.39461  -36.74178 -16.50525 0.557 13.70403 ? 1746 GLU A CA   1 
ATOM   4620 C  C    A GLU A 1 287 ? -4.42750  -37.23430 -17.54270 0.443 13.49353 ? 1746 GLU A C    1 
ATOM   4621 C  C    B GLU A 1 287 ? -4.41311  -37.22639 -17.53370 0.557 12.74083 ? 1746 GLU A C    1 
ATOM   4622 O  O    A GLU A 1 287 ? -5.60399  -37.46415 -17.23245 0.443 13.55667 ? 1746 GLU A O    1 
ATOM   4623 O  O    B GLU A 1 287 ? -5.58299  -37.47474 -17.20373 0.557 12.89607 ? 1746 GLU A O    1 
ATOM   4624 C  CB   A GLU A 1 287 ? -2.83294  -37.98853 -15.77943 0.443 18.09666 ? 1746 GLU A CB   1 
ATOM   4625 C  CB   B GLU A 1 287 ? -2.77506  -37.96440 -15.81187 0.557 16.22276 ? 1746 GLU A CB   1 
ATOM   4626 C  CG   A GLU A 1 287 ? -3.90861  -38.90141 -15.21663 0.443 21.46550 ? 1746 GLU A CG   1 
ATOM   4627 C  CG   B GLU A 1 287 ? -1.53660  -37.68051 -14.96034 0.557 18.96257 ? 1746 GLU A CG   1 
ATOM   4628 C  CD   A GLU A 1 287 ? -3.54108  -39.59924 -13.91904 0.443 24.96321 ? 1746 GLU A CD   1 
ATOM   4629 C  CD   B GLU A 1 287 ? -0.95891  -38.94745 -14.29053 0.557 22.33132 ? 1746 GLU A CD   1 
ATOM   4630 O  OE1  A GLU A 1 287 ? -2.36595  -40.01624 -13.76249 0.443 26.69497 ? 1746 GLU A OE1  1 
ATOM   4631 O  OE1  B GLU A 1 287 ? -0.73673  -39.95438 -14.99647 0.557 24.87107 ? 1746 GLU A OE1  1 
ATOM   4632 O  OE2  A GLU A 1 287 ? -4.45845  -39.74622 -13.06039 0.443 25.37382 ? 1746 GLU A OE2  1 
ATOM   4633 O  OE2  B GLU A 1 287 ? -0.72486  -38.92695 -13.05282 0.557 21.80764 ? 1746 GLU A OE2  1 
ATOM   4634 H  H    A GLU A 1 287 ? -4.05620  -36.20608 -14.72543 0.443 15.71850 ? 1746 GLU A H    1 
ATOM   4635 H  H    B GLU A 1 287 ? -4.03848  -36.20017 -14.72431 0.557 14.99527 ? 1746 GLU A H    1 
ATOM   4636 H  HA   A GLU A 1 287 ? -2.70400  -36.28655 -16.95394 0.443 17.75236 ? 1746 GLU A HA   1 
ATOM   4637 H  HA   B GLU A 1 287 ? -2.69521  -36.24287 -16.95560 0.557 16.44483 ? 1746 GLU A HA   1 
ATOM   4638 H  HB2  A GLU A 1 287 ? -2.30061  -38.50187 -16.40712 0.443 21.71599 ? 1746 GLU A HB2  1 
ATOM   4639 H  HB2  B GLU A 1 287 ? -3.44365  -38.35530 -15.22784 0.557 19.46731 ? 1746 GLU A HB2  1 
ATOM   4640 H  HB3  A GLU A 1 287 ? -2.27834  -37.68708 -15.04292 0.443 21.71599 ? 1746 GLU A HB3  1 
ATOM   4641 H  HB3  B GLU A 1 287 ? -2.51611  -38.60342 -16.49414 0.557 19.46731 ? 1746 GLU A HB3  1 
ATOM   4642 H  HG2  A GLU A 1 287 ? -4.70357  -38.37212 -15.04697 0.443 25.75859 ? 1746 GLU A HG2  1 
ATOM   4643 H  HG2  B GLU A 1 287 ? -0.84611  -37.30039 -15.52570 0.557 22.75508 ? 1746 GLU A HG2  1 
ATOM   4644 H  HG3  A GLU A 1 287 ? -4.10199  -39.58972 -15.87217 0.443 25.75859 ? 1746 GLU A HG3  1 
ATOM   4645 H  HG3  B GLU A 1 287 ? -1.77357  -37.05364 -14.25907 0.557 22.75508 ? 1746 GLU A HG3  1 
ATOM   4646 N  N    . ASP A 1 288 ? -3.95482  -37.42232 -18.77648 1.000 13.39882 ? 1747 ASP A N    1 
ATOM   4647 C  CA   A ASP A 1 288 ? -4.73705  -37.99514 -19.86818 0.533 13.96986 ? 1747 ASP A CA   1 
ATOM   4648 C  CA   B ASP A 1 288 ? -4.75730  -38.04322 -19.82473 0.467 14.05407 ? 1747 ASP A CA   1 
ATOM   4649 C  C    . ASP A 1 288 ? -6.14535  -37.43173 -19.90893 1.000 13.90141 ? 1747 ASP A C    1 
ATOM   4650 O  O    . ASP A 1 288 ? -7.15138  -38.14708 -19.90291 1.000 14.22514 ? 1747 ASP A O    1 
ATOM   4651 C  CB   A ASP A 1 288 ? -4.74583  -39.53508 -19.79231 0.533 14.93577 ? 1747 ASP A CB   1 
ATOM   4652 C  CB   B ASP A 1 288 ? -4.87898  -39.57463 -19.60141 0.467 14.99367 ? 1747 ASP A CB   1 
ATOM   4653 C  CG   A ASP A 1 288 ? -5.01705  -40.16713 -21.12506 0.533 16.34645 ? 1747 ASP A CG   1 
ATOM   4654 C  CG   B ASP A 1 288 ? -3.55462  -40.27315 -19.50172 0.467 16.25432 ? 1747 ASP A CG   1 
ATOM   4655 O  OD1  A ASP A 1 288 ? -5.03999  -39.48332 -22.16825 0.533 17.85976 ? 1747 ASP A OD1  1 
ATOM   4656 O  OD1  B ASP A 1 288 ? -2.80943  -40.20131 -20.47375 0.467 16.00956 ? 1747 ASP A OD1  1 
ATOM   4657 O  OD2  A ASP A 1 288 ? -5.21954  -41.37224 -21.13318 0.533 17.52551 ? 1747 ASP A OD2  1 
ATOM   4658 O  OD2  B ASP A 1 288 ? -3.30511  -40.89572 -18.45280 0.467 17.76762 ? 1747 ASP A OD2  1 
ATOM   4659 H  H    A ASP A 1 288 ? -3.15347  -37.21744 -19.01200 0.443 16.07858 ? 1747 ASP A H    1 
ATOM   4660 H  H    B ASP A 1 288 ? -3.16645  -37.19804 -19.03682 0.557 16.07858 ? 1747 ASP A H    1 
ATOM   4661 H  HA   A ASP A 1 288 ? -4.31195  -37.73761 -20.70117 0.533 16.76383 ? 1747 ASP A HA   1 
ATOM   4662 H  HA   B ASP A 1 288 ? -4.30354  -37.87874 -20.66612 0.467 16.86488 ? 1747 ASP A HA   1 
ATOM   4663 H  HB2  A ASP A 1 288 ? -3.87992  -39.84328 -19.48230 0.533 17.92292 ? 1747 ASP A HB2  1 
ATOM   4664 H  HB2  B ASP A 1 288 ? -5.36081  -39.73310 -18.77460 0.467 17.99241 ? 1747 ASP A HB2  1 
ATOM   4665 H  HB3  A ASP A 1 288 ? -5.43916  -39.81931 -19.17635 0.533 17.92292 ? 1747 ASP A HB3  1 
ATOM   4666 H  HB3  B ASP A 1 288 ? -5.36328  -39.96222 -20.34715 0.467 17.99241 ? 1747 ASP A HB3  1 
ATOM   4667 N  N    . THR A 1 289 ? -6.18718  -36.10328 -20.00595 1.000 12.93820 ? 1748 THR A N    1 
ATOM   4668 C  CA   . THR A 1 289 ? -7.45068  -35.35442 -19.91947 1.000 13.14860 ? 1748 THR A CA   1 
ATOM   4669 C  C    . THR A 1 289 ? -7.44256  -34.29493 -21.00594 1.000 12.49074 ? 1748 THR A C    1 
ATOM   4670 O  O    . THR A 1 289 ? -6.49864  -33.49090 -21.08072 1.000 14.20668 ? 1748 THR A O    1 
ATOM   4671 C  CB   . THR A 1 289 ? -7.58956  -34.72015 -18.54616 1.000 12.76708 ? 1748 THR A CB   1 
ATOM   4672 O  OG1  . THR A 1 289 ? -7.67992  -35.73643 -17.52863 1.000 11.86173 ? 1748 THR A OG1  1 
ATOM   4673 C  CG2  . THR A 1 289 ? -8.81770  -33.81084 -18.42322 1.000 12.42231 ? 1748 THR A CG2  1 
ATOM   4674 H  H    . THR A 1 289 ? -5.49518  -35.60621 -20.12282 1.000 15.52584 ? 1748 THR A H    1 
ATOM   4675 H  HA   . THR A 1 289 ? -8.21375  -35.93518 -20.06556 1.000 15.77833 ? 1748 THR A HA   1 
ATOM   4676 H  HB   . THR A 1 289 ? -6.80143  -34.17085 -18.41194 1.000 15.32049 ? 1748 THR A HB   1 
ATOM   4677 H  HG1  . THR A 1 289 ? -6.98453  -36.20762 -17.53064 1.000 14.23408 ? 1748 THR A HG1  1 
ATOM   4678 H  HG21 . THR A 1 289 ? -8.94126  -33.54335 -17.49906 1.000 14.90677 ? 1748 THR A HG21 1 
ATOM   4679 H  HG22 . THR A 1 289 ? -8.69844  -33.01685 -18.96751 1.000 14.90677 ? 1748 THR A HG22 1 
ATOM   4680 H  HG23 . THR A 1 289 ? -9.61071  -34.28201 -18.72328 1.000 14.90677 ? 1748 THR A HG23 1 
ATOM   4681 N  N    . TYR A 1 290 ? -8.48637  -34.27741 -21.83086 1.000 12.36969 ? 1749 TYR A N    1 
ATOM   4682 C  CA   . TYR A 1 290 ? -8.54624  -33.30754 -22.90670 1.000 13.28031 ? 1749 TYR A CA   1 
ATOM   4683 C  C    . TYR A 1 290 ? -9.98978  -33.20471 -23.40393 1.000 12.69082 ? 1749 TYR A C    1 
ATOM   4684 O  O    . TYR A 1 290 ? -10.83345 -34.05351 -23.10691 1.000 13.28553 ? 1749 TYR A O    1 
ATOM   4685 C  CB   . TYR A 1 290 ? -7.56301  -33.64079 -24.02531 1.000 14.75421 ? 1749 TYR A CB   1 
ATOM   4686 C  CG   . TYR A 1 290 ? -7.71632  -34.99098 -24.59006 1.000 16.67021 ? 1749 TYR A CG   1 
ATOM   4687 C  CD1  . TYR A 1 290 ? -7.05923  -36.06481 -24.01746 1.000 18.72570 ? 1749 TYR A CD1  1 
ATOM   4688 C  CD2  . TYR A 1 290 ? -8.51130  -35.23809 -25.68582 1.000 18.18612 ? 1749 TYR A CD2  1 
ATOM   4689 C  CE1  . TYR A 1 290 ? -7.15845  -37.34926 -24.50995 1.000 20.00740 ? 1749 TYR A CE1  1 
ATOM   4690 C  CE2  . TYR A 1 290 ? -8.61581  -36.55418 -26.21674 1.000 19.72571 ? 1749 TYR A CE2  1 
ATOM   4691 C  CZ   . TYR A 1 290 ? -7.95158  -37.57812 -25.59194 1.000 20.22603 ? 1749 TYR A CZ   1 
ATOM   4692 O  OH   . TYR A 1 290 ? -8.02367  -38.85490 -26.06574 1.000 25.24209 ? 1749 TYR A OH   1 
ATOM   4693 H  H    . TYR A 1 290 ? -9.15949  -34.81069 -21.78472 1.000 14.84363 ? 1749 TYR A H    1 
ATOM   4694 H  HA   . TYR A 1 290 ? -8.30173  -32.43417 -22.56269 1.000 15.93637 ? 1749 TYR A HA   1 
ATOM   4695 H  HB2  . TYR A 1 290 ? -7.68921  -33.00525 -24.74716 1.000 17.70505 ? 1749 TYR A HB2  1 
ATOM   4696 H  HB3  . TYR A 1 290 ? -6.66115  -33.57036 -23.67517 1.000 17.70505 ? 1749 TYR A HB3  1 
ATOM   4697 H  HD1  . TYR A 1 290 ? -6.52820  -35.91449 -23.26893 1.000 22.47085 ? 1749 TYR A HD1  1 
ATOM   4698 H  HD2  . TYR A 1 290 ? -8.98290  -34.54104 -26.08157 1.000 21.82335 ? 1749 TYR A HD2  1 
ATOM   4699 H  HE1  . TYR A 1 290 ? -6.69149  -38.04682 -24.10963 1.000 24.00888 ? 1749 TYR A HE1  1 
ATOM   4700 H  HE2  . TYR A 1 290 ? -9.12707  -36.71739 -26.97626 1.000 23.67085 ? 1749 TYR A HE2  1 
ATOM   4701 H  HH   . TYR A 1 290 ? -8.55248  -38.89008 -26.71745 1.000 30.29051 ? 1749 TYR A HH   1 
ATOM   4702 N  N    . VAL A 1 291 ? -10.21945 -32.17535 -24.21030 1.000 12.22493 ? 1750 VAL A N    1 
ATOM   4703 C  CA   . VAL A 1 291 ? -11.52932 -31.79839 -24.70955 1.000 12.83031 ? 1750 VAL A CA   1 
ATOM   4704 C  C    . VAL A 1 291 ? -11.40049 -31.58135 -26.20643 1.000 13.60146 ? 1750 VAL A C    1 
ATOM   4705 O  O    . VAL A 1 291 ? -10.53418 -30.81801 -26.64564 1.000 16.02258 ? 1750 VAL A O    1 
ATOM   4706 C  CB   . VAL A 1 291 ? -12.00042 -30.48492 -24.03343 1.000 13.75138 ? 1750 VAL A CB   1 
ATOM   4707 C  CG1  . VAL A 1 291 ? -13.36923 -30.08135 -24.59530 1.000 14.73305 ? 1750 VAL A CG1  1 
ATOM   4708 C  CG2  . VAL A 1 291 ? -12.03865 -30.64938 -22.54401 1.000 14.12252 ? 1750 VAL A CG2  1 
ATOM   4709 H  H    . VAL A 1 291 ? -9.59720  -31.65463 -24.49536 1.000 14.66991 ? 1750 VAL A H    1 
ATOM   4710 H  HA   . VAL A 1 291 ? -12.17493 -32.50320 -24.54430 1.000 15.39637 ? 1750 VAL A HA   1 
ATOM   4711 H  HB   . VAL A 1 291 ? -11.37434 -29.76949 -24.22600 1.000 16.50165 ? 1750 VAL A HB   1 
ATOM   4712 H  HG11 . VAL A 1 291 ? -13.74654 -29.38362 -24.03698 1.000 17.67966 ? 1750 VAL A HG11 1 
ATOM   4713 H  HG12 . VAL A 1 291 ? -13.25476 -29.75432 -25.50131 1.000 17.67966 ? 1750 VAL A HG12 1 
ATOM   4714 H  HG13 . VAL A 1 291 ? -13.95195 -30.85680 -24.59469 1.000 17.67966 ? 1750 VAL A HG13 1 
ATOM   4715 H  HG21 . VAL A 1 291 ? -12.39793 -29.84098 -22.14615 1.000 16.94703 ? 1750 VAL A HG21 1 
ATOM   4716 H  HG22 . VAL A 1 291 ? -12.60454 -31.40594 -22.32425 1.000 16.94703 ? 1750 VAL A HG22 1 
ATOM   4717 H  HG23 . VAL A 1 291 ? -11.13764 -30.80518 -22.22027 1.000 16.94703 ? 1750 VAL A HG23 1 
ATOM   4718 N  N    . GLU A 1 292 ? -12.24189 -32.21752 -26.99779 1.000 13.39091 ? 1751 GLU A N    1 
ATOM   4719 C  CA   . GLU A 1 292 ? -12.25572 -32.03096 -28.43377 1.000 14.26459 ? 1751 GLU A CA   1 
ATOM   4720 C  C    . GLU A 1 292 ? -13.46240 -31.17442 -28.80550 1.000 13.11190 ? 1751 GLU A C    1 
ATOM   4721 O  O    . GLU A 1 292 ? -14.60885 -31.51276 -28.46221 1.000 13.41980 ? 1751 GLU A O    1 
ATOM   4722 C  CB   . GLU A 1 292 ? -12.32355 -33.37819 -29.15222 1.000 15.05164 ? 1751 GLU A CB   1 
ATOM   4723 C  CG   . GLU A 1 292 ? -11.01745 -34.14801 -29.02068 1.000 18.39672 ? 1751 GLU A CG   1 
ATOM   4724 C  CD   . GLU A 1 292 ? -11.13554 -35.62641 -29.44198 1.000 21.54980 ? 1751 GLU A CD   1 
ATOM   4725 O  OE1  . GLU A 1 292 ? -12.23780 -36.08609 -29.74921 1.000 24.70262 ? 1751 GLU A OE1  1 
ATOM   4726 O  OE2  . GLU A 1 292 ? -10.08798 -36.31378 -29.51665 1.000 25.20524 ? 1751 GLU A OE2  1 
ATOM   4727 H  H    . GLU A 1 292 ? -12.83097 -32.77832 -26.71836 1.000 16.06909 ? 1751 GLU A H    1 
ATOM   4728 H  HA   . GLU A 1 292 ? -11.44736 -31.57186 -28.71067 1.000 17.11751 ? 1751 GLU A HA   1 
ATOM   4729 H  HB2  . GLU A 1 292 ? -13.03373 -33.91283 -28.76403 1.000 18.06197 ? 1751 GLU A HB2  1 
ATOM   4730 H  HB3  . GLU A 1 292 ? -12.49725 -33.23007 -30.09498 1.000 18.06197 ? 1751 GLU A HB3  1 
ATOM   4731 H  HG2  . GLU A 1 292 ? -10.34850 -33.73020 -29.58534 1.000 22.07606 ? 1751 GLU A HG2  1 
ATOM   4732 H  HG3  . GLU A 1 292 ? -10.73113 -34.12456 -28.09420 1.000 22.07606 ? 1751 GLU A HG3  1 
ATOM   4733 N  N    . VAL A 1 293 ? -13.20952 -30.07231 -29.50284 1.000 13.44611 ? 1752 VAL A N    1 
ATOM   4734 C  CA   . VAL A 1 293 ? -14.27015 -29.15381 -29.90937 1.000 13.07770 ? 1752 VAL A CA   1 
ATOM   4735 C  C    . VAL A 1 293 ? -14.31652 -29.06571 -31.42594 1.000 13.34886 ? 1752 VAL A C    1 
ATOM   4736 O  O    . VAL A 1 293 ? -13.32110 -29.22378 -32.13694 1.000 14.68567 ? 1752 VAL A O    1 
ATOM   4737 C  CB   . VAL A 1 293 ? -14.15140 -27.77707 -29.24713 1.000 15.08843 ? 1752 VAL A CB   1 
ATOM   4738 C  CG1  . VAL A 1 293 ? -14.16272 -27.86882 -27.74777 1.000 15.69111 ? 1752 VAL A CG1  1 
ATOM   4739 C  CG2  . VAL A 1 293 ? -12.86907 -27.07838 -29.72471 1.000 16.40954 ? 1752 VAL A CG2  1 
ATOM   4740 H  H    . VAL A 1 293 ? -12.42355 -29.83152 -29.75556 1.000 16.13533 ? 1752 VAL A H    1 
ATOM   4741 H  HA   . VAL A 1 293 ? -15.12096 -29.52408 -29.62668 1.000 15.69324 ? 1752 VAL A HA   1 
ATOM   4742 H  HB   . VAL A 1 293 ? -14.92345 -27.25047 -29.50700 1.000 18.10612 ? 1752 VAL A HB   1 
ATOM   4743 H  HG11 . VAL A 1 293 ? -14.12043 -26.97377 -27.37628 1.000 18.82934 ? 1752 VAL A HG11 1 
ATOM   4744 H  HG12 . VAL A 1 293 ? -14.98075 -28.30629 -27.46431 1.000 18.82934 ? 1752 VAL A HG12 1 
ATOM   4745 H  HG13 . VAL A 1 293 ? -13.39412 -28.38425 -27.45711 1.000 18.82934 ? 1752 VAL A HG13 1 
ATOM   4746 H  HG21 . VAL A 1 293 ? -12.73193 -26.27554 -29.19790 1.000 19.69145 ? 1752 VAL A HG21 1 
ATOM   4747 H  HG22 . VAL A 1 293 ? -12.11869 -27.68209 -29.60907 1.000 19.69145 ? 1752 VAL A HG22 1 
ATOM   4748 H  HG23 . VAL A 1 293 ? -12.96588 -26.84670 -30.66165 1.000 19.69145 ? 1752 VAL A HG23 1 
ATOM   4749 N  N    . ASP A 1 294 ? -15.52711 -28.77629 -31.93534 1.000 14.95153 ? 1753 ASP A N    1 
ATOM   4750 C  CA   . ASP A 1 294 ? -15.79861 -28.56088 -33.35490 1.000 15.95178 ? 1753 ASP A CA   1 
ATOM   4751 C  C    . ASP A 1 294 ? -16.10896 -27.07680 -33.47601 1.000 16.15701 ? 1753 ASP A C    1 
ATOM   4752 O  O    . ASP A 1 294 ? -17.12300 -26.60963 -32.94524 1.000 16.59124 ? 1753 ASP A O    1 
ATOM   4753 C  CB   . ASP A 1 294 ? -17.00462 -29.40273 -33.78569 1.000 19.20472 ? 1753 ASP A CB   1 
ATOM   4754 C  CG   . ASP A 1 294 ? -17.44610 -29.12783 -35.19295 1.000 22.49461 ? 1753 ASP A CG   1 
ATOM   4755 O  OD1  . ASP A 1 294 ? -16.96398 -28.21287 -35.84801 1.000 22.85770 ? 1753 ASP A OD1  1 
ATOM   4756 O  OD2  . ASP A 1 294 ? -18.33014 -29.86761 -35.64947 1.000 26.04743 ? 1753 ASP A OD2  1 
ATOM   4757 H  H    . ASP A 1 294 ? -16.23315 -28.69765 -31.45065 1.000 17.94183 ? 1753 ASP A H    1 
ATOM   4758 H  HA   . ASP A 1 294 ? -15.04195 -28.79956 -33.91294 1.000 19.14213 ? 1753 ASP A HA   1 
ATOM   4759 H  HB2  . ASP A 1 294 ? -16.76993 -30.34197 -33.72521 1.000 23.04567 ? 1753 ASP A HB2  1 
ATOM   4760 H  HB3  . ASP A 1 294 ? -17.75011 -29.20844 -33.19629 1.000 23.04567 ? 1753 ASP A HB3  1 
ATOM   4761 N  N    . LEU A 1 295 ? -15.21170 -26.34896 -34.11521 1.000 18.29140 ? 1754 LEU A N    1 
ATOM   4762 C  CA   . LEU A 1 295 ? -15.30129 -24.90044 -34.17680 1.000 19.37845 ? 1754 LEU A CA   1 
ATOM   4763 C  C    . LEU A 1 295 ? -16.21363 -24.41437 -35.28056 1.000 20.48118 ? 1754 LEU A C    1 
ATOM   4764 O  O    . LEU A 1 295 ? -16.44392 -23.20331 -35.38543 1.000 22.18133 ? 1754 LEU A O    1 
ATOM   4765 C  CB   . LEU A 1 295 ? -13.90996 -24.28270 -34.34873 1.000 20.77594 ? 1754 LEU A CB   1 
ATOM   4766 C  CG   . LEU A 1 295 ? -12.90844 -24.51322 -33.20614 1.000 21.48400 ? 1754 LEU A CG   1 
ATOM   4767 C  CD1  . LEU A 1 295 ? -11.59458 -23.75423 -33.51406 1.000 23.61831 ? 1754 LEU A CD1  1 
ATOM   4768 C  CD2  . LEU A 1 295 ? -13.44383 -24.12766 -31.85153 1.000 23.02088 ? 1754 LEU A CD2  1 
ATOM   4769 H  H    . LEU A 1 295 ? -14.53064 -26.67340 -34.52810 1.000 21.94968 ? 1754 LEU A H    1 
ATOM   4770 H  HA   . LEU A 1 295 ? -15.65832 -24.58095 -33.33338 1.000 23.25414 ? 1754 LEU A HA   1 
ATOM   4771 H  HB2  . LEU A 1 295 ? -13.51438 -24.65356 -35.15301 1.000 24.93113 ? 1754 LEU A HB2  1 
ATOM   4772 H  HB3  . LEU A 1 295 ? -14.01733 -23.32336 -34.44378 1.000 24.93113 ? 1754 LEU A HB3  1 
ATOM   4773 H  HG   . LEU A 1 295 ? -12.73328 -25.46574 -33.15212 1.000 25.78080 ? 1754 LEU A HG   1 
ATOM   4774 H  HD11 . LEU A 1 295 ? -10.96931 -23.89721 -32.78640 1.000 28.34197 ? 1754 LEU A HD11 1 
ATOM   4775 H  HD12 . LEU A 1 295 ? -11.22093 -24.09299 -34.34263 1.000 28.34197 ? 1754 LEU A HD12 1 
ATOM   4776 H  HD13 . LEU A 1 295 ? -11.78953 -22.80806 -33.60158 1.000 28.34197 ? 1754 LEU A HD13 1 
ATOM   4777 H  HD21 . LEU A 1 295 ? -12.73072 -24.19965 -31.19793 1.000 27.62506 ? 1754 LEU A HD21 1 
ATOM   4778 H  HD22 . LEU A 1 295 ? -13.76781 -23.21410 -31.88834 1.000 27.62506 ? 1754 LEU A HD22 1 
ATOM   4779 H  HD23 . LEU A 1 295 ? -14.16959 -24.72679 -31.61658 1.000 27.62506 ? 1754 LEU A HD23 1 
ATOM   4780 N  N    . GLU A 1 296 ? -16.67538 -25.30428 -36.17011 1.000 20.41808 ? 1755 GLU A N    1 
ATOM   4781 C  CA   . GLU A 1 296 ? -17.45295 -24.87282 -37.31401 1.000 24.36583 ? 1755 GLU A CA   1 
ATOM   4782 C  C    . GLU A 1 296 ? -18.95056 -25.01601 -37.09640 1.000 23.82900 ? 1755 GLU A C    1 
ATOM   4783 O  O    . GLU A 1 296 ? -19.71590 -24.39905 -37.82775 1.000 26.38440 ? 1755 GLU A O    1 
ATOM   4784 C  CB   . GLU A 1 296 ? -17.05592 -25.69274 -38.54211 1.000 28.28213 ? 1755 GLU A CB   1 
ATOM   4785 C  CG   . GLU A 1 296 ? -15.74049 -25.23096 -39.24330 1.000 33.70640 ? 1755 GLU A CG   1 
ATOM   4786 C  CD   . GLU A 1 296 ? -15.57784 -23.70844 -39.33783 1.000 38.07270 ? 1755 GLU A CD   1 
ATOM   4787 O  OE1  . GLU A 1 296 ? -14.77882 -23.12940 -38.55455 1.000 39.94395 ? 1755 GLU A OE1  1 
ATOM   4788 O  OE2  . GLU A 1 296 ? -16.26195 -23.07745 -40.19023 1.000 39.60970 ? 1755 GLU A OE2  1 
ATOM   4789 H  H    . GLU A 1 296 ? -16.54710 -26.15342 -36.12410 1.000 24.50170 ? 1755 GLU A H    1 
ATOM   4790 H  HA   . GLU A 1 296 ? -17.26356 -23.93899 -37.49564 1.000 29.23899 ? 1755 GLU A HA   1 
ATOM   4791 H  HB2  . GLU A 1 296 ? -16.93195 -26.61516 -38.26886 1.000 33.93856 ? 1755 GLU A HB2  1 
ATOM   4792 H  HB3  . GLU A 1 296 ? -17.77048 -25.63341 -39.19539 1.000 33.93856 ? 1755 GLU A HB3  1 
ATOM   4793 H  HG2  . GLU A 1 296 ? -14.98451 -25.57647 -38.74329 1.000 40.44768 ? 1755 GLU A HG2  1 
ATOM   4794 H  HG3  . GLU A 1 296 ? -15.72998 -25.58397 -40.14672 1.000 40.44768 ? 1755 GLU A HG3  1 
ATOM   4795 N  N    . HIS A 1 297 ? -19.36576 -25.76406 -36.09422 1.000 23.32104 ? 1756 HIS A N    1 
ATOM   4796 C  CA   . HIS A 1 297 ? -20.77764 -26.07964 -35.92126 1.000 23.37358 ? 1756 HIS A CA   1 
ATOM   4797 C  C    . HIS A 1 297 ? -21.55655 -24.87010 -35.40975 1.000 21.47073 ? 1756 HIS A C    1 
ATOM   4798 O  O    . HIS A 1 297 ? -21.36639 -24.44215 -34.26460 1.000 20.28121 ? 1756 HIS A O    1 
ATOM   4799 C  CB   . HIS A 1 297 ? -20.94244 -27.25870 -34.95289 1.000 23.87375 ? 1756 HIS A CB   1 
ATOM   4800 C  CG   . HIS A 1 297 ? -22.35525 -27.73914 -34.84654 1.000 26.39239 ? 1756 HIS A CG   1 
ATOM   4801 N  ND1  . HIS A 1 297 ? -23.04434 -27.79337 -33.64713 1.000 28.09252 ? 1756 HIS A ND1  1 
ATOM   4802 C  CD2  . HIS A 1 297 ? -23.20220 -28.21653 -35.78882 1.000 27.52145 ? 1756 HIS A CD2  1 
ATOM   4803 C  CE1  . HIS A 1 297 ? -24.26341 -28.25791 -33.86989 1.000 27.86364 ? 1756 HIS A CE1  1 
ATOM   4804 N  NE2  . HIS A 1 297 ? -24.38286 -28.51589 -35.15643 1.000 28.13731 ? 1756 HIS A NE2  1 
ATOM   4805 H  H    . HIS A 1 297 ? -18.85183 -26.10528 -35.49502 1.000 27.98525 ? 1756 HIS A H    1 
ATOM   4806 H  HA   . HIS A 1 297 ? -21.14137 -26.32504 -36.78635 1.000 28.04829 ? 1756 HIS A HA   1 
ATOM   4807 H  HB2  . HIS A 1 297 ? -20.39784 -27.99889 -35.26343 1.000 28.64850 ? 1756 HIS A HB2  1 
ATOM   4808 H  HB3  . HIS A 1 297 ? -20.65365 -26.98224 -34.06911 1.000 28.64850 ? 1756 HIS A HB3  1 
ATOM   4809 H  HD2  . HIS A 1 297 ? -23.01844 -28.32179 -36.69439 1.000 33.02574 ? 1756 HIS A HD2  1 
ATOM   4810 H  HE1  . HIS A 1 297 ? -24.92402 -28.38137 -33.22704 1.000 33.43637 ? 1756 HIS A HE1  1 
ATOM   4811 H  HE2  . HIS A 1 297 ? -25.08893 -28.82324 -35.53931 1.000 33.76477 ? 1756 HIS A HE2  1 
ATOM   4812 N  N    . GLU A 1 298 ? -22.50236 -24.39241 -36.22113 1.000 19.89954 ? 1757 GLU A N    1 
ATOM   4813 C  CA   . GLU A 1 298 ? -23.37426 -23.29276 -35.79663 1.000 20.39697 ? 1757 GLU A CA   1 
ATOM   4814 C  C    . GLU A 1 298 ? -24.68065 -23.82449 -35.20779 1.000 17.76776 ? 1757 GLU A C    1 
ATOM   4815 O  O    . GLU A 1 298 ? -25.30825 -24.73628 -35.77072 1.000 19.99682 ? 1757 GLU A O    1 
ATOM   4816 C  CB   . GLU A 1 298 ? -23.68021 -22.37836 -36.98104 1.000 23.87899 ? 1757 GLU A CB   1 
ATOM   4817 C  CG   . GLU A 1 298 ? -22.43407 -21.77560 -37.62599 1.000 28.69268 ? 1757 GLU A CG   1 
ATOM   4818 C  CD   . GLU A 1 298 ? -22.73548 -21.06880 -38.95022 1.000 34.01435 ? 1757 GLU A CD   1 
ATOM   4819 O  OE1  . GLU A 1 298 ? -23.26283 -21.73121 -39.87298 1.000 36.37507 ? 1757 GLU A OE1  1 
ATOM   4820 O  OE2  . GLU A 1 298 ? -22.45397 -19.86410 -39.05133 1.000 36.54615 ? 1757 GLU A OE2  1 
ATOM   4821 H  H    . GLU A 1 298 ? -22.65790 -24.68506 -37.01471 1.000 23.87945 ? 1757 GLU A H    1 
ATOM   4822 H  HA   . GLU A 1 298 ? -22.92472 -22.77942 -35.10722 1.000 24.47637 ? 1757 GLU A HA   1 
ATOM   4823 H  HB2  . GLU A 1 298 ? -24.14688 -22.89127 -37.65930 1.000 28.65479 ? 1757 GLU A HB2  1 
ATOM   4824 H  HB3  . GLU A 1 298 ? -24.23921 -21.64713 -36.67493 1.000 28.65479 ? 1757 GLU A HB3  1 
ATOM   4825 H  HG2  . GLU A 1 298 ? -22.04783 -21.12444 -37.01959 1.000 34.43122 ? 1757 GLU A HG2  1 
ATOM   4826 H  HG3  . GLU A 1 298 ? -21.79548 -22.48403 -37.80270 1.000 34.43122 ? 1757 GLU A HG3  1 
ATOM   4827 N  N    . TRP A 1 299 ? -25.10644 -23.23253 -34.10858 1.000 16.26754 ? 1758 TRP A N    1 
ATOM   4828 C  CA   . TRP A 1 299 ? -26.34778 -23.65877 -33.46164 1.000 16.20963 ? 1758 TRP A CA   1 
ATOM   4829 C  C    . TRP A 1 299 ? -26.88081 -22.49792 -32.64337 1.000 16.61229 ? 1758 TRP A C    1 
ATOM   4830 O  O    . TRP A 1 299 ? -26.18108 -21.51446 -32.37495 1.000 18.00715 ? 1758 TRP A O    1 
ATOM   4831 C  CB   . TRP A 1 299 ? -26.14034 -24.89571 -32.60068 1.000 16.50170 ? 1758 TRP A CB   1 
ATOM   4832 C  CG   . TRP A 1 299 ? -25.06362 -24.85403 -31.54004 1.000 15.58590 ? 1758 TRP A CG   1 
ATOM   4833 C  CD1  . TRP A 1 299 ? -23.70133 -24.87902 -31.74829 1.000 16.28327 ? 1758 TRP A CD1  1 
ATOM   4834 C  CD2  . TRP A 1 299 ? -25.24888 -24.86152 -30.12995 1.000 15.12795 ? 1758 TRP A CD2  1 
ATOM   4835 N  NE1  . TRP A 1 299 ? -23.04806 -24.88617 -30.55254 1.000 16.62011 ? 1758 TRP A NE1  1 
ATOM   4836 C  CE2  . TRP A 1 299 ? -23.97033 -24.89989 -29.53564 1.000 15.27006 ? 1758 TRP A CE2  1 
ATOM   4837 C  CE3  . TRP A 1 299 ? -26.36300 -24.85991 -29.29075 1.000 15.42527 ? 1758 TRP A CE3  1 
ATOM   4838 C  CZ2  . TRP A 1 299 ? -23.78616 -24.90075 -28.16792 1.000 14.88055 ? 1758 TRP A CZ2  1 
ATOM   4839 C  CZ3  . TRP A 1 299 ? -26.17717 -24.87741 -27.92402 1.000 16.22536 ? 1758 TRP A CZ3  1 
ATOM   4840 C  CH2  . TRP A 1 299 ? -24.88394 -24.91279 -27.36653 1.000 16.45167 ? 1758 TRP A CH2  1 
ATOM   4841 H  H    . TRP A 1 299 ? -24.70186 -22.58424 -33.71407 1.000 19.52105 ? 1758 TRP A H    1 
ATOM   4842 H  HA   . TRP A 1 299 ? -27.00287 -23.87957 -34.14209 1.000 19.45155 ? 1758 TRP A HA   1 
ATOM   4843 H  HB2  . TRP A 1 299 ? -26.97485 -25.07841 -32.14121 1.000 19.80204 ? 1758 TRP A HB2  1 
ATOM   4844 H  HB3  . TRP A 1 299 ? -25.91876 -25.63238 -33.19154 1.000 19.80204 ? 1758 TRP A HB3  1 
ATOM   4845 H  HD1  . TRP A 1 299 ? -23.28896 -24.88945 -32.58180 1.000 19.53992 ? 1758 TRP A HD1  1 
ATOM   4846 H  HE1  . TRP A 1 299 ? -22.19408 -24.88266 -30.45102 1.000 19.94413 ? 1758 TRP A HE1  1 
ATOM   4847 H  HE3  . TRP A 1 299 ? -27.22132 -24.84718 -29.64857 1.000 18.51033 ? 1758 TRP A HE3  1 
ATOM   4848 H  HZ2  . TRP A 1 299 ? -22.93077 -24.89327 -27.80302 1.000 17.85666 ? 1758 TRP A HZ2  1 
ATOM   4849 H  HZ3  . TRP A 1 299 ? -26.91765 -24.86565 -27.36148 1.000 19.47043 ? 1758 TRP A HZ3  1 
ATOM   4850 H  HH2  . TRP A 1 299 ? -24.78049 -24.94465 -26.44286 1.000 19.74200 ? 1758 TRP A HH2  1 
ATOM   4851 N  N    . THR A 1 300 ? -28.13912 -22.62220 -32.23845 1.000 15.62798 ? 1759 THR A N    1 
ATOM   4852 C  CA   . THR A 1 300 ? -28.82170 -21.61342 -31.43403 1.000 15.68323 ? 1759 THR A CA   1 
ATOM   4853 C  C    . THR A 1 300 ? -29.10839 -22.17837 -30.05331 1.000 15.22524 ? 1759 THR A C    1 
ATOM   4854 O  O    . THR A 1 300 ? -29.61161 -23.31970 -29.92943 1.000 16.08852 ? 1759 THR A O    1 
ATOM   4855 C  CB   . THR A 1 300 ? -30.11192 -21.19851 -32.14785 1.000 17.15715 ? 1759 THR A CB   1 
ATOM   4856 O  OG1  . THR A 1 300 ? -29.77497 -20.65419 -33.42412 1.000 19.32567 ? 1759 THR A OG1  1 
ATOM   4857 C  CG2  . THR A 1 300 ? -30.88652 -20.16441 -31.34095 1.000 19.19410 ? 1759 THR A CG2  1 
ATOM   4858 H  H    . THR A 1 300 ? -28.63325 -23.30169 -32.42213 1.000 18.75357 ? 1759 THR A H    1 
ATOM   4859 H  HA   . THR A 1 300 ? -28.26595 -20.82857 -31.30730 1.000 18.81987 ? 1759 THR A HA   1 
ATOM   4860 H  HB   . THR A 1 300 ? -30.68701 -21.97234 -32.25442 1.000 20.58858 ? 1759 THR A HB   1 
ATOM   4861 H  HG1  . THR A 1 300 ? -30.47234 -20.42103 -33.83021 1.000 23.19081 ? 1759 THR A HG1  1 
ATOM   4862 H  HG21 . THR A 1 300 ? -31.61452 -19.80621 -31.87256 1.000 23.03292 ? 1759 THR A HG21 1 
ATOM   4863 H  HG22 . THR A 1 300 ? -31.25243 -20.57376 -30.54130 1.000 23.03292 ? 1759 THR A HG22 1 
ATOM   4864 H  HG23 . THR A 1 300 ? -30.29871 -19.43762 -31.08179 1.000 23.03292 ? 1759 THR A HG23 1 
ATOM   4865 N  N    . ILE A 1 301 ? -28.78032 -21.41181 -29.02652 1.000 14.05672 ? 1760 ILE A N    1 
ATOM   4866 C  CA   A ILE A 1 301 ? -28.99015 -21.89434 -27.65959 0.766 13.32769 ? 1760 ILE A CA   1 
ATOM   4867 C  CA   B ILE A 1 301 ? -28.99696 -21.83485 -27.64080 0.234 14.40412 ? 1760 ILE A CA   1 
ATOM   4868 C  C    . ILE A 1 301 ? -30.49035 -22.07273 -27.41776 1.000 14.49621 ? 1760 ILE A C    1 
ATOM   4869 O  O    . ILE A 1 301 ? -31.29393 -21.13605 -27.66195 1.000 14.95946 ? 1760 ILE A O    1 
ATOM   4870 C  CB   A ILE A 1 301 ? -28.35855 -20.94751 -26.64083 0.766 12.85133 ? 1760 ILE A CB   1 
ATOM   4871 C  CB   B ILE A 1 301 ? -28.47954 -20.77374 -26.65265 0.234 14.81996 ? 1760 ILE A CB   1 
ATOM   4872 C  CG1  A ILE A 1 301 ? -26.83075 -20.97496 -26.87734 0.766 14.14618 ? 1760 ILE A CG1  1 
ATOM   4873 C  CG1  B ILE A 1 301 ? -27.00488 -20.45102 -26.92547 0.234 15.27263 ? 1760 ILE A CG1  1 
ATOM   4874 C  CG2  A ILE A 1 301 ? -28.72017 -21.33931 -25.23208 0.766 13.46189 ? 1760 ILE A CG2  1 
ATOM   4875 C  CG2  B ILE A 1 301 ? -28.68791 -21.23025 -25.21650 0.234 15.00945 ? 1760 ILE A CG2  1 
ATOM   4876 C  CD1  A ILE A 1 301 ? -26.06891 -20.05622 -26.00710 0.766 13.64614 ? 1760 ILE A CD1  1 
ATOM   4877 C  CD1  B ILE A 1 301 ? -26.06460 -21.59944 -26.68085 0.234 14.69102 ? 1760 ILE A CD1  1 
ATOM   4878 H  H    A ILE A 1 301 ? -28.44120 -20.62372 -29.08573 0.766 16.86806 ? 1760 ILE A H    1 
ATOM   4879 H  H    B ILE A 1 301 ? -28.42604 -20.63168 -29.10059 0.234 16.86806 ? 1760 ILE A H    1 
ATOM   4880 H  HA   A ILE A 1 301 ? -28.56133 -22.75824 -27.55616 0.766 15.99322 ? 1760 ILE A HA   1 
ATOM   4881 H  HA   B ILE A 1 301 ? -28.52165 -22.66756 -27.49390 0.234 17.28495 ? 1760 ILE A HA   1 
ATOM   4882 H  HB   A ILE A 1 301 ? -28.69572 -20.04578 -26.75961 0.766 15.42160 ? 1760 ILE A HB   1 
ATOM   4883 H  HB   B ILE A 1 301 ? -28.99095 -19.96029 -26.78552 0.234 17.78395 ? 1760 ILE A HB   1 
ATOM   4884 H  HG12 A ILE A 1 301 ? -26.50696 -21.87415 -26.71145 0.766 16.97541 ? 1760 ILE A HG12 1 
ATOM   4885 H  HG12 B ILE A 1 301 ? -26.91202 -20.18808 -27.85452 0.234 18.32715 ? 1760 ILE A HG12 1 
ATOM   4886 H  HG13 A ILE A 1 301 ? -26.65439 -20.72330 -27.79738 0.766 16.97541 ? 1760 ILE A HG13 1 
ATOM   4887 H  HG13 B ILE A 1 301 ? -26.73494 -19.72171 -26.34570 0.234 18.32715 ? 1760 ILE A HG13 1 
ATOM   4888 H  HG21 A ILE A 1 301 ? -28.19927 -20.80522 -24.61216 0.766 16.15426 ? 1760 ILE A HG21 1 
ATOM   4889 H  HG21 B ILE A 1 301 ? -28.16957 -20.66147 -24.62598 0.234 18.01135 ? 1760 ILE A HG21 1 
ATOM   4890 H  HG22 A ILE A 1 301 ? -29.66659 -21.17878 -25.09271 0.766 16.15426 ? 1760 ILE A HG22 1 
ATOM   4891 H  HG22 B ILE A 1 301 ? -29.63042 -21.16297 -24.99734 0.234 18.01135 ? 1760 ILE A HG22 1 
ATOM   4892 H  HG23 A ILE A 1 301 ? -28.52211 -22.28037 -25.10530 0.766 16.15426 ? 1760 ILE A HG23 1 
ATOM   4893 H  HG23 B ILE A 1 301 ? -28.39348 -22.15060 -25.13182 0.234 18.01135 ? 1760 ILE A HG23 1 
ATOM   4894 H  HD11 A ILE A 1 301 ? -25.16583 -19.97169 -26.35092 0.766 16.37537 ? 1760 ILE A HD11 1 
ATOM   4895 H  HD11 B ILE A 1 301 ? -25.15269 -21.29278 -26.80443 0.234 17.62922 ? 1760 ILE A HD11 1 
ATOM   4896 H  HD12 A ILE A 1 301 ? -26.50445 -19.18950 -26.00481 0.766 16.37537 ? 1760 ILE A HD12 1 
ATOM   4897 H  HD12 B ILE A 1 301 ? -26.18594 -21.91909 -25.77311 0.234 17.62922 ? 1760 ILE A HD12 1 
ATOM   4898 H  HD13 A ILE A 1 301 ? -26.04780 -20.41819 -25.10742 0.766 16.37537 ? 1760 ILE A HD13 1 
ATOM   4899 H  HD13 B ILE A 1 301 ? -26.26298 -22.30973 -27.31096 0.234 17.62922 ? 1760 ILE A HD13 1 
ATOM   4900 N  N    . PRO A 1 302 ? -30.92954 -23.25158 -26.95890 1.000 14.55424 ? 1761 PRO A N    1 
ATOM   4901 C  CA   . PRO A 1 302 ? -32.36632 -23.51825 -26.75710 1.000 15.28844 ? 1761 PRO A CA   1 
ATOM   4902 C  C    . PRO A 1 302 ? -32.82943 -22.97778 -25.41268 1.000 14.69894 ? 1761 PRO A C    1 
ATOM   4903 O  O    . PRO A 1 302 ? -32.09475 -22.25643 -24.71404 1.000 15.36736 ? 1761 PRO A O    1 
ATOM   4904 C  CB   . PRO A 1 302 ? -32.40743 -25.04556 -26.78435 1.000 16.41221 ? 1761 PRO A CB   1 
ATOM   4905 C  CG   . PRO A 1 302 ? -31.09222 -25.43315 -26.19994 1.000 16.93861 ? 1761 PRO A CG   1 
ATOM   4906 C  CD   . PRO A 1 302 ? -30.10833 -24.43766 -26.68771 1.000 16.74117 ? 1761 PRO A CD   1 
ATOM   4907 H  HA   . PRO A 1 302 ? -32.91463 -23.15764 -27.47139 1.000 18.34612 ? 1761 PRO A HA   1 
ATOM   4908 H  HB2  . PRO A 1 302 ? -33.14417 -25.37274 -26.24484 1.000 19.69465 ? 1761 PRO A HB2  1 
ATOM   4909 H  HB3  . PRO A 1 302 ? -32.49679 -25.36427 -27.69613 1.000 19.69465 ? 1761 PRO A HB3  1 
ATOM   4910 H  HG2  . PRO A 1 302 ? -31.14797 -25.41227 -25.23177 1.000 20.32633 ? 1761 PRO A HG2  1 
ATOM   4911 H  HG3  . PRO A 1 302 ? -30.85352 -26.32437 -26.49936 1.000 20.32633 ? 1761 PRO A HG3  1 
ATOM   4912 H  HD2  . PRO A 1 302 ? -29.44330 -24.24832 -26.00742 1.000 20.08941 ? 1761 PRO A HD2  1 
ATOM   4913 H  HD3  . PRO A 1 302 ? -29.67500 -24.74947 -27.49759 1.000 20.08941 ? 1761 PRO A HD3  1 
ATOM   4914 N  N    . SER A 1 303 ? -34.10429 -23.26438 -25.06695 1.000 14.64366 ? 1762 SER A N    1 
ATOM   4915 C  CA   . SER A 1 303 ? -34.67646 -22.70507 -23.85037 1.000 15.13318 ? 1762 SER A CA   1 
ATOM   4916 C  C    . SER A 1 303 ? -34.10538 -23.33855 -22.59703 1.000 14.49361 ? 1762 SER A C    1 
ATOM   4917 O  O    . SER A 1 303 ? -34.17609 -22.73069 -21.53978 1.000 15.35421 ? 1762 SER A O    1 
ATOM   4918 C  CB   . SER A 1 303 ? -36.23092 -22.77399 -23.87076 1.000 17.34392 ? 1762 SER A CB   1 
ATOM   4919 O  OG   . SER A 1 303 ? -36.65262 -24.10371 -24.02664 1.000 19.53621 ? 1762 SER A OG   1 
ATOM   4920 H  H    . SER A 1 303 ? -34.63586 -23.76895 -25.51689 1.000 17.57239 ? 1762 SER A H    1 
ATOM   4921 H  HA   . SER A 1 303 ? -34.45551 -21.76119 -23.81629 1.000 18.15982 ? 1762 SER A HA   1 
ATOM   4922 H  HB2  . SER A 1 303 ? -36.57643 -22.42605 -23.03383 1.000 20.81270 ? 1762 SER A HB2  1 
ATOM   4923 H  HB3  . SER A 1 303 ? -36.56374 -22.24499 -24.61258 1.000 20.81270 ? 1762 SER A HB3  1 
ATOM   4924 H  HG   . SER A 1 303 ? -36.36962 -24.41132 -24.75526 1.000 23.44345 ? 1762 SER A HG   1 
ATOM   4925 N  N    . HIS A 1 304 ? -33.52427 -24.54006 -22.70526 1.000 13.70141 ? 1763 HIS A N    1 
ATOM   4926 C  CA   . HIS A 1 304 ? -32.78932 -25.12966 -21.59498 1.000 14.41992 ? 1763 HIS A CA   1 
ATOM   4927 C  C    . HIS A 1 304 ? -31.72471 -26.05699 -22.15222 1.000 13.63826 ? 1763 HIS A C    1 
ATOM   4928 O  O    . HIS A 1 304 ? -31.92448 -26.68633 -23.18633 1.000 14.81990 ? 1763 HIS A O    1 
ATOM   4929 C  CB   . HIS A 1 304 ? -33.69791 -25.87281 -20.58998 1.000 14.95425 ? 1763 HIS A CB   1 
ATOM   4930 C  CG   . HIS A 1 304 ? -34.30315 -27.11341 -21.14760 1.000 16.62021 ? 1763 HIS A CG   1 
ATOM   4931 N  ND1  . HIS A 1 304 ? -35.54364 -27.12320 -21.75189 1.000 17.62815 ? 1763 HIS A ND1  1 
ATOM   4932 C  CD2  . HIS A 1 304 ? -33.84953 -28.39368 -21.18941 1.000 18.18881 ? 1763 HIS A CD2  1 
ATOM   4933 C  CE1  . HIS A 1 304 ? -35.80894 -28.34815 -22.16155 1.000 18.97573 ? 1763 HIS A CE1  1 
ATOM   4934 N  NE2  . HIS A 1 304 ? -34.78921 -29.12946 -21.85429 1.000 20.59685 ? 1763 HIS A NE2  1 
ATOM   4935 H  H    . HIS A 1 304 ? -33.54506 -25.02785 -23.41323 1.000 16.44169 ? 1763 HIS A H    1 
ATOM   4936 H  HA   . HIS A 1 304 ? -32.35240 -24.42058 -21.09778 1.000 17.30390 ? 1763 HIS A HA   1 
ATOM   4937 H  HB2  . HIS A 1 304 ? -33.17043 -26.12120 -19.81476 1.000 17.94510 ? 1763 HIS A HB2  1 
ATOM   4938 H  HB3  . HIS A 1 304 ? -34.42025 -25.28238 -20.32442 1.000 17.94510 ? 1763 HIS A HB3  1 
ATOM   4939 H  HD2  . HIS A 1 304 ? -33.05064 -28.70925 -20.83290 1.000 21.82658 ? 1763 HIS A HD2  1 
ATOM   4940 H  HE1  . HIS A 1 304 ? -36.58614 -28.61764 -22.59542 1.000 22.77088 ? 1763 HIS A HE1  1 
ATOM   4941 H  HE2  . HIS A 1 304 ? -34.72687 -29.96631 -22.04242 1.000 24.71622 ? 1763 HIS A HE2  1 
ATOM   4942 N  N    . MET A 1 305 ? -30.55989 -26.09714 -21.47287 1.000 13.80667 ? 1764 MET A N    1 
ATOM   4943 C  CA   . MET A 1 305 ? -29.53296 -27.03101 -21.87038 1.000 13.68298 ? 1764 MET A CA   1 
ATOM   4944 C  C    . MET A 1 305 ? -29.84521 -28.40143 -21.26312 1.000 13.81192 ? 1764 MET A C    1 
ATOM   4945 O  O    . MET A 1 305 ? -30.64106 -28.52103 -20.34451 1.000 13.88036 ? 1764 MET A O    1 
ATOM   4946 C  CB   . MET A 1 305 ? -28.14193 -26.50403 -21.41910 1.000 13.15413 ? 1764 MET A CB   1 
ATOM   4947 C  CG   . MET A 1 305 ? -27.84133 -25.16247 -22.11225 1.000 16.40437 ? 1764 MET A CG   1 
ATOM   4948 S  SD   . MET A 1 305 ? -27.75019 -25.24424 -23.87948 1.000 18.53606 ? 1764 MET A SD   1 
ATOM   4949 C  CE   . MET A 1 305 ? -26.29682 -26.37549 -24.05375 1.000 17.86237 ? 1764 MET A CE   1 
ATOM   4950 H  H    . MET A 1 305 ? -30.36242 -25.60037 -20.79920 1.000 16.56800 ? 1764 MET A H    1 
ATOM   4951 H  HA   . MET A 1 305 ? -29.49233 -27.11849 -22.83557 1.000 16.41957 ? 1764 MET A HA   1 
ATOM   4952 H  HB2  . MET A 1 305 ? -28.14014 -26.36705 -20.45882 1.000 15.78496 ? 1764 MET A HB2  1 
ATOM   4953 H  HB3  . MET A 1 305 ? -27.45494 -27.14342 -21.66429 1.000 15.78496 ? 1764 MET A HB3  1 
ATOM   4954 H  HG2  . MET A 1 305 ? -28.54450 -24.53394 -21.88552 1.000 19.68525 ? 1764 MET A HG2  1 
ATOM   4955 H  HG3  . MET A 1 305 ? -26.98683 -24.83428 -21.79129 1.000 19.68525 ? 1764 MET A HG3  1 
ATOM   4956 H  HE1  . MET A 1 305 ? -26.11835 -26.51738 -24.99657 1.000 21.43484 ? 1764 MET A HE1  1 
ATOM   4957 H  HE2  . MET A 1 305 ? -25.52620 -25.96730 -23.62899 1.000 21.43484 ? 1764 MET A HE2  1 
ATOM   4958 H  HE3  . MET A 1 305 ? -26.50163 -27.22111 -23.62494 1.000 21.43484 ? 1764 MET A HE3  1 
ATOM   4959 N  N    . PRO A 1 306 ? -29.21837 -29.47546 -21.76425 1.000 13.41723 ? 1765 PRO A N    1 
ATOM   4960 C  CA   . PRO A 1 306 ? -29.68384 -30.80992 -21.35770 1.000 14.90420 ? 1765 PRO A CA   1 
ATOM   4961 C  C    . PRO A 1 306 ? -29.48125 -31.19111 -19.90954 1.000 15.31476 ? 1765 PRO A C    1 
ATOM   4962 O  O    . PRO A 1 306 ? -30.27788 -32.01231 -19.40496 1.000 17.69388 ? 1765 PRO A O    1 
ATOM   4963 C  CB   . PRO A 1 306 ? -28.87319 -31.74348 -22.28136 1.000 17.12012 ? 1765 PRO A CB   1 
ATOM   4964 C  CG   . PRO A 1 306 ? -28.63698 -30.95430 -23.48501 1.000 16.12797 ? 1765 PRO A CG   1 
ATOM   4965 C  CD   . PRO A 1 306 ? -28.46131 -29.52117 -23.02534 1.000 14.22255 ? 1765 PRO A CD   1 
ATOM   4966 H  HA   . PRO A 1 306 ? -30.63516 -30.85788 -21.54100 1.000 17.88504 ? 1765 PRO A HA   1 
ATOM   4967 H  HB2  . PRO A 1 306 ? -28.03691 -31.98782 -21.85493 1.000 20.54415 ? 1765 PRO A HB2  1 
ATOM   4968 H  HB3  . PRO A 1 306 ? -29.38830 -32.54043 -22.48245 1.000 20.54415 ? 1765 PRO A HB3  1 
ATOM   4969 H  HG2  . PRO A 1 306 ? -27.83553 -31.27141 -23.93001 1.000 19.35357 ? 1765 PRO A HG2  1 
ATOM   4970 H  HG3  . PRO A 1 306 ? -29.39935 -31.03170 -24.07973 1.000 19.35357 ? 1765 PRO A HG3  1 
ATOM   4971 H  HD2  . PRO A 1 306 ? -27.52473 -29.31966 -22.87332 1.000 17.06706 ? 1765 PRO A HD2  1 
ATOM   4972 H  HD3  . PRO A 1 306 ? -28.83276 -28.90262 -23.67367 1.000 17.06706 ? 1765 PRO A HD3  1 
ATOM   4973 N  N    . PHE A 1 307 ? -28.42389 -30.70956 -19.23041 1.000 13.21723 ? 1766 PHE A N    1 
ATOM   4974 C  CA   . PHE A 1 307 ? -28.05809 -31.28805 -17.96267 1.000 12.61180 ? 1766 PHE A CA   1 
ATOM   4975 C  C    . PHE A 1 307 ? -28.43571 -30.50874 -16.72321 1.000 12.66179 ? 1766 PHE A C    1 
ATOM   4976 O  O    . PHE A 1 307 ? -28.87717 -31.10474 -15.73975 1.000 13.81192 ? 1766 PHE A O    1 
ATOM   4977 C  CB   . PHE A 1 307 ? -26.57239 -31.68314 -17.92395 1.000 12.90660 ? 1766 PHE A CB   1 
ATOM   4978 C  CG   . PHE A 1 307 ? -26.23716 -32.75325 -18.91479 1.000 13.44090 ? 1766 PHE A CG   1 
ATOM   4979 C  CD1  . PHE A 1 307 ? -26.59083 -34.07239 -18.65451 1.000 14.46467 ? 1766 PHE A CD1  1 
ATOM   4980 C  CD2  . PHE A 1 307 ? -25.63242 -32.46977 -20.12962 1.000 14.35149 ? 1766 PHE A CD2  1 
ATOM   4981 C  CE1  . PHE A 1 307 ? -26.33867 -35.07328 -19.59734 1.000 16.38857 ? 1766 PHE A CE1  1 
ATOM   4982 C  CE2  . PHE A 1 307 ? -25.41992 -33.44181 -21.07753 1.000 15.69895 ? 1766 PHE A CE2  1 
ATOM   4983 C  CZ   . PHE A 1 307 ? -25.74623 -34.74421 -20.81728 1.000 16.45165 ? 1766 PHE A CZ   1 
ATOM   4984 H  H    . PHE A 1 307 ? -27.92434 -30.06081 -19.49342 1.000 15.86067 ? 1766 PHE A H    1 
ATOM   4985 H  HA   . PHE A 1 307 ? -28.58184 -32.10264 -17.90756 1.000 15.13416 ? 1766 PHE A HA   1 
ATOM   4986 H  HB2  . PHE A 1 307 ? -26.03217 -30.90377 -18.12804 1.000 15.48792 ? 1766 PHE A HB2  1 
ATOM   4987 H  HB3  . PHE A 1 307 ? -26.35586 -32.01421 -17.03828 1.000 15.48792 ? 1766 PHE A HB3  1 
ATOM   4988 H  HD1  . PHE A 1 307 ? -26.99810 -34.29051 -17.84738 1.000 17.35761 ? 1766 PHE A HD1  1 
ATOM   4989 H  HD2  . PHE A 1 307 ? -25.36310 -31.59768 -20.30803 1.000 17.22179 ? 1766 PHE A HD2  1 
ATOM   4990 H  HE1  . PHE A 1 307 ? -26.56511 -35.95606 -19.41207 1.000 19.66629 ? 1766 PHE A HE1  1 
ATOM   4991 H  HE2  . PHE A 1 307 ? -25.05221 -33.21275 -21.90046 1.000 18.83874 ? 1766 PHE A HE2  1 
ATOM   4992 H  HZ   . PHE A 1 307 ? -25.57466 -35.40540 -21.44838 1.000 19.74198 ? 1766 PHE A HZ   1 
ATOM   4993 N  N    . SER A 1 308 ? -28.20418 -29.21191 -16.68472 1.000 11.49329 ? 1767 SER A N    1 
ATOM   4994 C  CA   A SER A 1 308 ? -28.46189 -28.46471 -15.45946 0.000 11.44850 ? 1767 SER A CA   1 
ATOM   4995 C  CA   B SER A 1 308 ? -28.45206 -28.51821 -15.44651 1.000 11.30370 ? 1767 SER A CA   1 
ATOM   4996 C  C    . SER A 1 308 ? -29.91389 -28.63686 -15.02209 1.000 11.82481 ? 1767 SER A C    1 
ATOM   4997 O  O    . SER A 1 308 ? -30.84597 -28.44518 -15.82208 1.000 11.20637 ? 1767 SER A O    1 
ATOM   4998 C  CB   A SER A 1 308 ? -28.14406 -26.98411 -15.68292 0.000 11.36691 ? 1767 SER A CB   1 
ATOM   4999 C  CB   B SER A 1 308 ? -28.11999 -27.01182 -15.58528 1.000 11.16423 ? 1767 SER A CB   1 
ATOM   5000 O  OG   A SER A 1 308 ? -28.59012 -26.54690 -16.95560 0.000 11.38796 ? 1767 SER A OG   1 
ATOM   5001 O  OG   B SER A 1 308 ? -28.46661 -26.31616 -14.39541 1.000 11.17480 ? 1767 SER A OG   1 
ATOM   5002 H  H    A SER A 1 308 ? -27.90299 -28.74338 -17.33998 0.000 13.79195 ? 1767 SER A H    1 
ATOM   5003 H  H    B SER A 1 308 ? -27.91498 -28.73170 -17.33691 1.000 13.79195 ? 1767 SER A H    1 
ATOM   5004 H  HA   A SER A 1 308 ? -27.89242 -28.79884 -14.74885 0.000 13.73820 ? 1767 SER A HA   1 
ATOM   5005 H  HA   B SER A 1 308 ? -27.88544 -28.91827 -14.76843 1.000 13.56444 ? 1767 SER A HA   1 
ATOM   5006 H  HB2  A SER A 1 308 ? -28.58877 -26.46088 -14.99782 0.000 13.64029 ? 1767 SER A HB2  1 
ATOM   5007 H  HB2  B SER A 1 308 ? -27.16902 -26.90994 -15.74703 1.000 13.39707 ? 1767 SER A HB2  1 
ATOM   5008 H  HB3  A SER A 1 308 ? -27.18405 -26.85729 -15.62635 0.000 13.64029 ? 1767 SER A HB3  1 
ATOM   5009 H  HB3  B SER A 1 308 ? -28.62413 -26.64262 -16.32720 1.000 13.39707 ? 1767 SER A HB3  1 
ATOM   5010 H  HG   A SER A 1 308 ? -28.10118 -26.86930 -17.55776 0.000 13.66555 ? 1767 SER A HG   1 
ATOM   5011 H  HG   B SER A 1 308 ? -28.03759 -26.62889 -13.74445 1.000 13.40977 ? 1767 SER A HG   1 
ATOM   5012 N  N    . LYS A 1 309 ? -30.10278 -28.88907 -13.74682 1.000 11.50122 ? 1768 LYS A N    1 
ATOM   5013 C  CA   . LYS A 1 309 ? -31.46396 -28.95460 -13.21432 1.000 12.30384 ? 1768 LYS A CA   1 
ATOM   5014 C  C    . LYS A 1 309 ? -32.14281 -27.58253 -13.19000 1.000 12.49601 ? 1768 LYS A C    1 
ATOM   5015 O  O    . LYS A 1 309 ? -33.36955 -27.50427 -12.99364 1.000 14.34616 ? 1768 LYS A O    1 
ATOM   5016 C  CB   . LYS A 1 309 ? -31.48950 -29.54901 -11.83780 1.000 13.14606 ? 1768 LYS A CB   1 
ATOM   5017 C  CG   . LYS A 1 309 ? -31.12023 -31.00922 -11.71463 1.000 14.35150 ? 1768 LYS A CG   1 
ATOM   5018 C  CD   . LYS A 1 309 ? -31.33769 -31.48543 -10.29062 1.000 16.63864 ? 1768 LYS A CD   1 
ATOM   5019 C  CE   . LYS A 1 309 ? -30.67963 -32.75963 -9.94466  1.000 19.90211 ? 1768 LYS A CE   1 
ATOM   5020 N  NZ   . LYS A 1 309 ? -31.22454 -33.30136 -8.64690  1.000 22.93135 ? 1768 LYS A NZ   1 
ATOM   5021 H  H    . LYS A 1 309 ? -29.47835 -29.02491 -13.17129 1.000 13.80146 ? 1768 LYS A H    1 
ATOM   5022 H  HA   . LYS A 1 309 ? -31.97685 -29.54825 -13.78478 1.000 14.76461 ? 1768 LYS A HA   1 
ATOM   5023 H  HB2  . LYS A 1 309 ? -30.86528 -29.05246 -11.28582 1.000 15.77528 ? 1768 LYS A HB2  1 
ATOM   5024 H  HB3  . LYS A 1 309 ? -32.38929 -29.45491 -11.48788 1.000 15.77528 ? 1768 LYS A HB3  1 
ATOM   5025 H  HG2  . LYS A 1 309 ? -31.67726 -31.53784 -12.30723 1.000 17.22180 ? 1768 LYS A HG2  1 
ATOM   5026 H  HG3  . LYS A 1 309 ? -30.18522 -31.12979 -11.94292 1.000 17.22180 ? 1768 LYS A HG3  1 
ATOM   5027 H  HD2  . LYS A 1 309 ? -30.99435 -30.80961 -9.68540  1.000 19.96637 ? 1768 LYS A HD2  1 
ATOM   5028 H  HD3  . LYS A 1 309 ? -32.28988 -31.60459 -10.14910 1.000 19.96637 ? 1768 LYS A HD3  1 
ATOM   5029 H  HE2  . LYS A 1 309 ? -30.84412 -33.41065 -10.64466 1.000 23.88253 ? 1768 LYS A HE2  1 
ATOM   5030 H  HE3  . LYS A 1 309 ? -29.72578 -32.61547 -9.84314  1.000 23.88253 ? 1768 LYS A HE3  1 
ATOM   5031 H  HZ1  . LYS A 1 309 ? -31.07363 -32.72233 -7.98807  1.000 27.51763 ? 1768 LYS A HZ1  1 
ATOM   5032 H  HZ2  . LYS A 1 309 ? -32.10140 -33.43628 -8.71765  1.000 27.51763 ? 1768 LYS A HZ2  1 
ATOM   5033 H  HZ3  . LYS A 1 309 ? -30.82853 -34.07349 -8.44918  1.000 27.51763 ? 1768 LYS A HZ3  1 
ATOM   5034 N  N    . ALA A 1 310 ? -31.40397 -26.51502 -13.44166 1.000 12.63024 ? 1769 ALA A N    1 
ATOM   5035 C  CA   . ALA A 1 310 ? -32.06364 -25.21322 -13.56019 1.000 12.19858 ? 1769 ALA A CA   1 
ATOM   5036 C  C    . ALA A 1 310 ? -33.15349 -25.25391 -14.64591 1.000 11.56962 ? 1769 ALA A C    1 
ATOM   5037 O  O    . ALA A 1 310 ? -34.19971 -24.60889 -14.50986 1.000 12.15643 ? 1769 ALA A O    1 
ATOM   5038 C  CB   . ALA A 1 310 ? -31.02852 -24.13286 -13.88332 1.000 11.56433 ? 1769 ALA A CB   1 
ATOM   5039 H  H    . ALA A 1 310 ? -30.55027 -26.51004 -13.54546 1.000 15.15629 ? 1769 ALA A H    1 
ATOM   5040 H  HA   . ALA A 1 310 ? -32.48069 -24.98756 -12.71400 1.000 14.63829 ? 1769 ALA A HA   1 
ATOM   5041 H  HB1  . ALA A 1 310 ? -31.47712 -23.27536 -13.94936 1.000 13.87719 ? 1769 ALA A HB1  1 
ATOM   5042 H  HB2  . ALA A 1 310 ? -30.36749 -24.10658 -13.17392 1.000 13.87719 ? 1769 ALA A HB2  1 
ATOM   5043 H  HB3  . ALA A 1 310 ? -30.60029 -24.34796 -14.72668 1.000 13.87719 ? 1769 ALA A HB3  1 
ATOM   5044 N  N    . HIS A 1 311 ? -32.89936 -25.97206 -15.72804 1.000 12.08280 ? 1770 HIS A N    1 
ATOM   5045 C  CA   . HIS A 1 311 ? -33.86032 -26.18097 -16.78330 1.000 13.45135 ? 1770 HIS A CA   1 
ATOM   5046 C  C    . HIS A 1 311 ? -34.32665 -24.87908 -17.43160 1.000 11.84863 ? 1770 HIS A C    1 
ATOM   5047 O  O    . HIS A 1 311 ? -35.47506 -24.74500 -17.83705 1.000 13.41184 ? 1770 HIS A O    1 
ATOM   5048 C  CB   . HIS A 1 311 ? -35.04104 -27.03013 -16.28452 1.000 14.48572 ? 1770 HIS A CB   1 
ATOM   5049 C  CG   . HIS A 1 311 ? -35.69958 -27.79549 -17.34476 1.000 16.40441 ? 1770 HIS A CG   1 
ATOM   5050 N  ND1  . HIS A 1 311 ? -36.90143 -27.41033 -17.89519 1.000 18.26507 ? 1770 HIS A ND1  1 
ATOM   5051 C  CD2  . HIS A 1 311 ? -35.33509 -28.93826 -17.97210 1.000 17.94668 ? 1770 HIS A CD2  1 
ATOM   5052 C  CE1  . HIS A 1 311 ? -37.26470 -28.29132 -18.81331 1.000 19.30464 ? 1770 HIS A CE1  1 
ATOM   5053 N  NE2  . HIS A 1 311 ? -36.33633 -29.22289 -18.88352 1.000 20.04945 ? 1770 HIS A NE2  1 
ATOM   5054 H  H    . HIS A 1 311 ? -32.14688 -26.36158 -15.87520 1.000 14.49936 ? 1770 HIS A H    1 
ATOM   5055 H  HA   . HIS A 1 311 ? -33.41742 -26.67147 -17.49334 1.000 16.14162 ? 1770 HIS A HA   1 
ATOM   5056 H  HB2  . HIS A 1 311 ? -34.71577 -27.65957 -15.62202 1.000 17.38287 ? 1770 HIS A HB2  1 
ATOM   5057 H  HB3  . HIS A 1 311 ? -35.70292 -26.44277 -15.88726 1.000 17.38287 ? 1770 HIS A HB3  1 
ATOM   5058 H  HD2  . HIS A 1 311 ? -34.56335 -29.43452 -17.82029 1.000 21.53602 ? 1770 HIS A HD2  1 
ATOM   5059 H  HE1  . HIS A 1 311 ? -38.04254 -28.25832 -19.32201 1.000 23.16556 ? 1770 HIS A HE1  1 
ATOM   5060 H  HE2  . HIS A 1 311 ? -36.35028 -29.90095 -19.41234 1.000 24.05934 ? 1770 HIS A HE2  1 
ATOM   5061 N  N    . TRP A 1 312 ? -33.41241 -23.91974 -17.54840 1.000 11.79589 ? 1771 TRP A N    1 
ATOM   5062 C  CA   . TRP A 1 312 ? -33.64660 -22.67323 -18.25863 1.000 11.08790 ? 1771 TRP A CA   1 
ATOM   5063 C  C    . TRP A 1 312 ? -32.26337 -22.07228 -18.52623 1.000 11.19853 ? 1771 TRP A C    1 
ATOM   5064 O  O    . TRP A 1 312 ? -31.25438 -22.52218 -17.96236 1.000 12.29595 ? 1771 TRP A O    1 
ATOM   5065 C  CB   . TRP A 1 312 ? -34.52374 -21.70101 -17.42236 1.000 10.59574 ? 1771 TRP A CB   1 
ATOM   5066 C  CG   . TRP A 1 312 ? -33.77606 -20.95203 -16.33824 1.000 10.43786 ? 1771 TRP A CG   1 
ATOM   5067 C  CD1  . TRP A 1 312 ? -33.46185 -21.40625 -15.08922 1.000 11.06162 ? 1771 TRP A CD1  1 
ATOM   5068 C  CD2  . TRP A 1 312 ? -33.26960 -19.62032 -16.42041 1.000 10.22997 ? 1771 TRP A CD2  1 
ATOM   5069 N  NE1  . TRP A 1 312 ? -32.69291 -20.45759 -14.40108 1.000 11.20895 ? 1771 TRP A NE1  1 
ATOM   5070 C  CE2  . TRP A 1 312 ? -32.60533 -19.35129 -15.20353 1.000 10.60634 ? 1771 TRP A CE2  1 
ATOM   5071 C  CE3  . TRP A 1 312 ? -33.33267 -18.63242 -17.39863 1.000 10.91418 ? 1771 TRP A CE3  1 
ATOM   5072 C  CZ2  . TRP A 1 312 ? -32.02671 -18.11099 -14.92625 1.000 11.66425 ? 1771 TRP A CZ2  1 
ATOM   5073 C  CZ3  . TRP A 1 312 ? -32.75902 -17.40726 -17.13323 1.000 9.70890  ? 1771 TRP A CZ3  1 
ATOM   5074 C  CH2  . TRP A 1 312 ? -32.11088 -17.17354 -15.92173 1.000 10.99841 ? 1771 TRP A CH2  1 
ATOM   5075 H  H    . TRP A 1 312 ? -32.62239 -23.97140 -17.21253 1.000 14.15507 ? 1771 TRP A H    1 
ATOM   5076 H  HA   . TRP A 1 312 ? -34.10694 -22.83486 -19.09700 1.000 13.30548 ? 1771 TRP A HA   1 
ATOM   5077 H  HB2  . TRP A 1 312 ? -34.90998 -21.04189 -18.02009 1.000 12.71489 ? 1771 TRP A HB2  1 
ATOM   5078 H  HB3  . TRP A 1 312 ? -35.22745 -22.21201 -16.99275 1.000 12.71489 ? 1771 TRP A HB3  1 
ATOM   5079 H  HD1  . TRP A 1 312 ? -33.72166 -22.22964 -14.74364 1.000 13.27394 ? 1771 TRP A HD1  1 
ATOM   5080 H  HE1  . TRP A 1 312 ? -32.34213 -20.55243 -13.62162 1.000 13.45074 ? 1771 TRP A HE1  1 
ATOM   5081 H  HE3  . TRP A 1 312 ? -33.75212 -18.79501 -18.21259 1.000 13.09702 ? 1771 TRP A HE3  1 
ATOM   5082 H  HZ2  . TRP A 1 312 ? -31.60933 -17.93211 -14.11465 1.000 13.99709 ? 1771 TRP A HZ2  1 
ATOM   5083 H  HZ3  . TRP A 1 312 ? -32.80499 -16.73000 -17.76892 1.000 11.65068 ? 1771 TRP A HZ3  1 
ATOM   5084 H  HH2  . TRP A 1 312 ? -31.71721 -16.34254 -15.78262 1.000 13.19809 ? 1771 TRP A HH2  1 
ATOM   5085 N  N    . THR A 1 313 ? -32.21273 -21.06214 -19.40997 1.000 11.50112 ? 1772 THR A N    1 
ATOM   5086 C  CA   . THR A 1 313 ? -30.93450 -20.33527 -19.62752 1.000 11.56692 ? 1772 THR A CA   1 
ATOM   5087 C  C    . THR A 1 313 ? -31.22051 -18.91503 -20.10014 1.000 11.35381 ? 1772 THR A C    1 
ATOM   5088 O  O    . THR A 1 313 ? -32.06490 -18.71049 -20.98227 1.000 13.00913 ? 1772 THR A O    1 
ATOM   5089 C  CB   . THR A 1 313 ? -30.02192 -21.06952 -20.60333 1.000 11.21955 ? 1772 THR A CB   1 
ATOM   5090 O  OG1  . THR A 1 313 ? -28.90847 -20.19322 -20.94855 1.000 11.00635 ? 1772 THR A OG1  1 
ATOM   5091 C  CG2  . THR A 1 313 ? -30.69843 -21.46431 -21.89942 1.000 12.19329 ? 1772 THR A CG2  1 
ATOM   5092 H  H    . THR A 1 313 ? -32.87676 -20.78489 -19.88092 1.000 13.80135 ? 1772 THR A H    1 
ATOM   5093 H  HA   . THR A 1 313 ? -30.46883 -20.25583 -18.78033 1.000 13.88030 ? 1772 THR A HA   1 
ATOM   5094 H  HB   . THR A 1 313 ? -29.73581 -21.88746 -20.16743 1.000 13.46345 ? 1772 THR A HB   1 
ATOM   5095 H  HG1  . THR A 1 313 ? -28.40618 -20.09114 -20.28305 1.000 13.20762 ? 1772 THR A HG1  1 
ATOM   5096 H  HG21 . THR A 1 313 ? -30.06355 -21.90814 -22.48325 1.000 14.63195 ? 1772 THR A HG21 1 
ATOM   5097 H  HG22 . THR A 1 313 ? -31.43532 -22.06855 -21.71838 1.000 14.63195 ? 1772 THR A HG22 1 
ATOM   5098 H  HG23 . THR A 1 313 ? -31.04101 -20.67570 -22.34846 1.000 14.63195 ? 1772 THR A HG23 1 
ATOM   5099 N  N    . PRO A 1 314 ? -30.47092 -17.93112 -19.61224 1.000 10.84061 ? 1773 PRO A N    1 
ATOM   5100 C  CA   . PRO A 1 314 ? -30.65568 -16.57244 -20.09969 1.000 11.64327 ? 1773 PRO A CA   1 
ATOM   5101 C  C    . PRO A 1 314 ? -30.11095 -16.33634 -21.49555 1.000 11.92488 ? 1773 PRO A C    1 
ATOM   5102 O  O    . PRO A 1 314 ? -30.39798 -15.29750 -22.09842 1.000 13.04866 ? 1773 PRO A O    1 
ATOM   5103 C  CB   . PRO A 1 314 ? -29.90938 -15.72586 -19.06290 1.000 11.50370 ? 1773 PRO A CB   1 
ATOM   5104 C  CG   . PRO A 1 314 ? -28.77506 -16.62874 -18.65823 1.000 11.23802 ? 1773 PRO A CG   1 
ATOM   5105 C  CD   . PRO A 1 314 ? -29.45192 -17.99865 -18.56709 1.000 11.58264 ? 1773 PRO A CD   1 
ATOM   5106 H  HA   . PRO A 1 314 ? -31.59738 -16.34030 -20.08549 1.000 13.97193 ? 1773 PRO A HA   1 
ATOM   5107 H  HB2  . PRO A 1 314 ? -29.58484 -14.90472 -19.46452 1.000 13.80444 ? 1773 PRO A HB2  1 
ATOM   5108 H  HB3  . PRO A 1 314 ? -30.48735 -15.52164 -18.31114 1.000 13.80444 ? 1773 PRO A HB3  1 
ATOM   5109 H  HG2  . PRO A 1 314 ? -28.07768 -16.62142 -19.33240 1.000 13.48563 ? 1773 PRO A HG2  1 
ATOM   5110 H  HG3  . PRO A 1 314 ? -28.41142 -16.35468 -17.80175 1.000 13.48563 ? 1773 PRO A HG3  1 
ATOM   5111 H  HD2  . PRO A 1 314 ? -28.81825 -18.71081 -18.74651 1.000 13.89917 ? 1773 PRO A HD2  1 
ATOM   5112 H  HD3  . PRO A 1 314 ? -29.85761 -18.12735 -17.69545 1.000 13.89917 ? 1773 PRO A HD3  1 
ATOM   5113 N  N    . PHE A 1 315 ? -29.32014 -17.26816 -22.03271 1.000 11.52750 ? 1774 PHE A N    1 
ATOM   5114 C  CA   . PHE A 1 315 ? -28.76534 -17.11508 -23.34761 1.000 11.15375 ? 1774 PHE A CA   1 
ATOM   5115 C  C    . PHE A 1 315 ? -29.63096 -17.69705 -24.45132 1.000 11.98537 ? 1774 PHE A C    1 
ATOM   5116 O  O    . PHE A 1 315 ? -29.21284 -17.73615 -25.61408 1.000 12.84336 ? 1774 PHE A O    1 
ATOM   5117 C  CB   . PHE A 1 315 ? -27.35808 -17.78363 -23.37517 1.000 11.91166 ? 1774 PHE A CB   1 
ATOM   5118 C  CG   . PHE A 1 315 ? -26.39388 -17.21862 -22.36428 1.000 11.08533 ? 1774 PHE A CG   1 
ATOM   5119 C  CD1  . PHE A 1 315 ? -25.76726 -15.98078 -22.57515 1.000 10.78265 ? 1774 PHE A CD1  1 
ATOM   5120 C  CD2  . PHE A 1 315 ? -26.15816 -17.89426 -21.20117 1.000 11.51694 ? 1774 PHE A CD2  1 
ATOM   5121 C  CE1  . PHE A 1 315 ? -24.89941 -15.51865 -21.64157 1.000 11.10633 ? 1774 PHE A CE1  1 
ATOM   5122 C  CE2  . PHE A 1 315 ? -25.26844 -17.42121 -20.25770 1.000 11.66955 ? 1774 PHE A CE2  1 
ATOM   5123 C  CZ   . PHE A 1 315 ? -24.63630 -16.22393 -20.47206 1.000 11.14586 ? 1774 PHE A CZ   1 
ATOM   5124 H  H    . PHE A 1 315 ? -29.09717 -17.99961 -21.63918 1.000 13.83300 ? 1774 PHE A H    1 
ATOM   5125 H  HA   . PHE A 1 315 ? -28.67593 -16.16812 -23.53779 1.000 13.38450 ? 1774 PHE A HA   1 
ATOM   5126 H  HB2  . PHE A 1 315 ? -27.45947 -18.73033 -23.18975 1.000 14.29399 ? 1774 PHE A HB2  1 
ATOM   5127 H  HB3  . PHE A 1 315 ? -26.97072 -17.65762 -24.25549 1.000 14.29399 ? 1774 PHE A HB3  1 
ATOM   5128 H  HD1  . PHE A 1 315 ? -25.94428 -15.48580 -23.34232 1.000 12.93918 ? 1774 PHE A HD1  1 
ATOM   5129 H  HD2  . PHE A 1 315 ? -26.60789 -18.69234 -21.04083 1.000 13.82033 ? 1774 PHE A HD2  1 
ATOM   5130 H  HE1  . PHE A 1 315 ? -24.46815 -14.70766 -21.78724 1.000 13.32760 ? 1774 PHE A HE1  1 
ATOM   5131 H  HE2  . PHE A 1 315 ? -25.09964 -17.90977 -19.48459 1.000 14.00346 ? 1774 PHE A HE2  1 
ATOM   5132 H  HZ   . PHE A 1 315 ? -24.03911 -15.88753 -19.84349 1.000 13.37504 ? 1774 PHE A HZ   1 
ATOM   5133 N  N    . GLU A 1 316 ? -30.84102 -18.15778 -24.11536 1.000 12.36444 ? 1775 GLU A N    1 
ATOM   5134 C  CA   . GLU A 1 316 ? -31.74852 -18.70209 -25.11967 1.000 13.58561 ? 1775 GLU A CA   1 
ATOM   5135 C  C    . GLU A 1 316 ? -31.85618 -17.75584 -26.32925 1.000 13.70408 ? 1775 GLU A C    1 
ATOM   5136 O  O    . GLU A 1 316 ? -32.01584 -16.51757 -26.16665 1.000 15.95162 ? 1775 GLU A O    1 
ATOM   5137 C  CB   . GLU A 1 316 ? -33.12943 -18.85090 -24.50044 1.000 14.53314 ? 1775 GLU A CB   1 
ATOM   5138 C  CG   . GLU A 1 316 ? -34.14579 -19.29818 -25.54690 1.000 15.93335 ? 1775 GLU A CG   1 
ATOM   5139 C  CD   . GLU A 1 316 ? -35.55657 -19.47915 -25.00053 1.000 19.61790 ? 1775 GLU A CD   1 
ATOM   5140 O  OE1  . GLU A 1 316 ? -35.79796 -19.14583 -23.81536 1.000 22.47334 ? 1775 GLU A OE1  1 
ATOM   5141 O  OE2  . GLU A 1 316 ? -36.43781 -19.89914 -25.79189 1.000 20.96537 ? 1775 GLU A OE2  1 
ATOM   5142 H  H    . GLU A 1 316 ? -31.15545 -18.16466 -23.31493 1.000 14.83733 ? 1775 GLU A H    1 
ATOM   5143 H  HA   . GLU A 1 316 ? -31.41811 -19.56334 -25.41963 1.000 16.30273 ? 1775 GLU A HA   1 
ATOM   5144 H  HB2  . GLU A 1 316 ? -33.09787 -19.51705 -23.79607 1.000 17.43977 ? 1775 GLU A HB2  1 
ATOM   5145 H  HB3  . GLU A 1 316 ? -33.41478 -17.99775 -24.13767 1.000 17.43977 ? 1775 GLU A HB3  1 
ATOM   5146 H  HG2  . GLU A 1 316 ? -34.18485 -18.62992 -26.24890 1.000 19.12002 ? 1775 GLU A HG2  1 
ATOM   5147 H  HG3  . GLU A 1 316 ? -33.86047 -20.14926 -25.91454 1.000 19.12002 ? 1775 GLU A HG3  1 
ATOM   5148 N  N    . GLY A 1 317 ? -31.70281 -18.29966 -27.50423 1.000 14.10149 ? 1776 GLY A N    1 
ATOM   5149 C  CA   . GLY A 1 317 ? -31.82938 -17.60018 -28.75861 1.000 15.39102 ? 1776 GLY A CA   1 
ATOM   5150 C  C    . GLY A 1 317 ? -30.55005 -17.04097 -29.31667 1.000 16.10428 ? 1776 GLY A C    1 
ATOM   5151 O  O    . GLY A 1 317 ? -30.54811 -16.57759 -30.45485 1.000 17.40442 ? 1776 GLY A O    1 
ATOM   5152 H  H    . GLY A 1 317 ? -31.51150 -19.13082 -27.61456 1.000 16.92179 ? 1776 GLY A H    1 
ATOM   5153 H  HA2  . GLY A 1 317 ? -32.19449 -18.21154 -29.41727 1.000 18.46922 ? 1776 GLY A HA2  1 
ATOM   5154 H  HA3  . GLY A 1 317 ? -32.44536 -16.86054 -28.63859 1.000 18.46922 ? 1776 GLY A HA3  1 
ATOM   5155 N  N    . GLN A 1 318 ? -29.48278 -17.03529 -28.53074 1.000 15.35687 ? 1777 GLN A N    1 
ATOM   5156 C  CA   . GLN A 1 318 ? -28.20465 -16.57547 -29.06496 1.000 14.60686 ? 1777 GLN A CA   1 
ATOM   5157 C  C    . GLN A 1 318 ? -27.60893 -17.61039 -30.01310 1.000 15.50429 ? 1777 GLN A C    1 
ATOM   5158 O  O    . GLN A 1 318 ? -27.68015 -18.82816 -29.76440 1.000 16.47541 ? 1777 GLN A O    1 
ATOM   5159 C  CB   . GLN A 1 318 ? -27.21736 -16.18986 -27.96279 1.000 16.10962 ? 1777 GLN A CB   1 
ATOM   5160 C  CG   . GLN A 1 318 ? -27.67123 -15.09840 -26.97758 1.000 18.05447 ? 1777 GLN A CG   1 
ATOM   5161 C  CD   . GLN A 1 318 ? -26.53240 -14.47672 -26.20882 1.000 17.99149 ? 1777 GLN A CD   1 
ATOM   5162 O  OE1  . GLN A 1 318 ? -25.42053 -15.04976 -26.14132 1.000 20.35211 ? 1777 GLN A OE1  1 
ATOM   5163 N  NE2  . GLN A 1 318 ? -26.78345 -13.37895 -25.52917 1.000 17.65451 ? 1777 GLN A NE2  1 
ATOM   5164 H  H    . GLN A 1 318 ? -29.46965 -17.28491 -27.70787 1.000 18.42824 ? 1777 GLN A H    1 
ATOM   5165 H  HA   . GLN A 1 318 ? -28.36151 -15.76409 -29.57285 1.000 17.52824 ? 1777 GLN A HA   1 
ATOM   5166 H  HB2  . GLN A 1 318 ? -27.02768 -16.98364 -27.43853 1.000 19.33155 ? 1777 GLN A HB2  1 
ATOM   5167 H  HB3  . GLN A 1 318 ? -26.40526 -15.86977 -28.38579 1.000 19.33155 ? 1777 GLN A HB3  1 
ATOM   5168 H  HG2  . GLN A 1 318 ? -28.11553 -14.39300 -27.47347 1.000 21.66537 ? 1777 GLN A HG2  1 
ATOM   5169 H  HG3  . GLN A 1 318 ? -28.28451 -15.48992 -26.33609 1.000 21.66537 ? 1777 GLN A HG3  1 
ATOM   5170 H  HE21 . GLN A 1 318 ? -27.57448 -13.04154 -25.53418 1.000 21.18541 ? 1777 GLN A HE21 1 
ATOM   5171 H  HE22 . GLN A 1 318 ? -26.15657 -12.99860 -25.07977 1.000 21.18541 ? 1777 GLN A HE22 1 
ATOM   5172 N  N    . LYS A 1 319 ? -27.04740 -17.12820 -31.10472 1.000 16.45700 ? 1778 LYS A N    1 
ATOM   5173 C  CA   A LYS A 1 319 ? -26.38420 -17.96528 -32.09713 0.503 16.70973 ? 1778 LYS A CA   1 
ATOM   5174 C  CA   B LYS A 1 319 ? -26.38864 -17.98293 -32.08205 0.497 17.08083 ? 1778 LYS A CA   1 
ATOM   5175 C  C    . LYS A 1 319 ? -24.91536 -18.10337 -31.73671 1.000 16.64656 ? 1778 LYS A C    1 
ATOM   5176 O  O    . LYS A 1 319 ? -24.24241 -17.10021 -31.45634 1.000 18.43085 ? 1778 LYS A O    1 
ATOM   5177 C  CB   A LYS A 1 319 ? -26.53190 -17.33964 -33.48669 0.503 19.03359 ? 1778 LYS A CB   1 
ATOM   5178 C  CB   B LYS A 1 319 ? -26.58597 -17.44339 -33.49871 0.497 20.08371 ? 1778 LYS A CB   1 
ATOM   5179 C  CG   A LYS A 1 319 ? -27.98459 -17.02518 -33.86335 0.503 20.59962 ? 1778 LYS A CG   1 
ATOM   5180 C  CG   B LYS A 1 319 ? -27.99922 -17.70690 -34.03066 0.497 22.27349 ? 1778 LYS A CG   1 
ATOM   5181 C  CD   A LYS A 1 319 ? -28.07620 -16.31007 -35.19074 0.503 23.12620 ? 1778 LYS A CD   1 
ATOM   5182 C  CD   B LYS A 1 319 ? -28.21149 -17.09911 -35.40521 0.497 25.01328 ? 1778 LYS A CD   1 
ATOM   5183 C  CE   A LYS A 1 319 ? -29.50266 -16.31480 -35.73735 0.503 24.91588 ? 1778 LYS A CE   1 
ATOM   5184 C  CE   B LYS A 1 319 ? -27.78266 -18.04394 -36.52058 0.497 27.43459 ? 1778 LYS A CE   1 
ATOM   5185 N  NZ   A LYS A 1 319 ? -29.51705 -16.18811 -37.22138 0.503 26.50550 ? 1778 LYS A NZ   1 
ATOM   5186 N  NZ   B LYS A 1 319 ? -27.82707 -17.36129 -37.86011 0.497 28.78210 ? 1778 LYS A NZ   1 
ATOM   5187 H  H    A LYS A 1 319 ? -27.03419 -16.29183 -31.30452 0.503 19.74840 ? 1778 LYS A H    1 
ATOM   5188 H  H    B LYS A 1 319 ? -27.03233 -16.29309 -31.30957 0.497 19.74840 ? 1778 LYS A H    1 
ATOM   5189 H  HA   A LYS A 1 319 ? -26.78236 -18.84970 -32.11063 0.503 20.05168 ? 1778 LYS A HA   1 
ATOM   5190 H  HA   B LYS A 1 319 ? -26.77577 -18.87197 -32.05673 0.497 20.49699 ? 1778 LYS A HA   1 
ATOM   5191 H  HB2  A LYS A 1 319 ? -26.03196 -16.50874 -33.51052 0.503 22.84031 ? 1778 LYS A HB2  1 
ATOM   5192 H  HB2  B LYS A 1 319 ? -26.43770 -16.48479 -33.49668 0.497 24.10045 ? 1778 LYS A HB2  1 
ATOM   5193 H  HB3  A LYS A 1 319 ? -26.18051 -17.95730 -34.14694 0.503 22.84031 ? 1778 LYS A HB3  1 
ATOM   5194 H  HB3  B LYS A 1 319 ? -25.95360 -17.87565 -34.09382 0.497 24.10045 ? 1778 LYS A HB3  1 
ATOM   5195 H  HG2  A LYS A 1 319 ? -28.48496 -17.85354 -33.92934 0.503 24.71954 ? 1778 LYS A HG2  1 
ATOM   5196 H  HG2  B LYS A 1 319 ? -28.14212 -18.66399 -34.09742 0.497 26.72819 ? 1778 LYS A HG2  1 
ATOM   5197 H  HG3  A LYS A 1 319 ? -28.37560 -16.45468 -33.18326 0.503 24.71954 ? 1778 LYS A HG3  1 
ATOM   5198 H  HG3  B LYS A 1 319 ? -28.64707 -17.31628 -33.42353 0.497 26.72819 ? 1778 LYS A HG3  1 
ATOM   5199 H  HD2  A LYS A 1 319 ? -27.79683 -15.38802 -35.07808 0.503 27.75144 ? 1778 LYS A HD2  1 
ATOM   5200 H  HD2  B LYS A 1 319 ? -29.15315 -16.89880 -35.52372 0.497 30.01593 ? 1778 LYS A HD2  1 
ATOM   5201 H  HD3  A LYS A 1 319 ? -27.50245 -16.75428 -35.83446 0.503 27.75144 ? 1778 LYS A HD3  1 
ATOM   5202 H  HD3  B LYS A 1 319 ? -27.68751 -16.28617 -35.47918 0.497 30.01593 ? 1778 LYS A HD3  1 
ATOM   5203 H  HE2  A LYS A 1 319 ? -29.93586 -17.14901 -35.49789 0.503 29.89906 ? 1778 LYS A HE2  1 
ATOM   5204 H  HE2  B LYS A 1 319 ? -26.87383 -18.34182 -36.35877 0.497 32.92151 ? 1778 LYS A HE2  1 
ATOM   5205 H  HE3  A LYS A 1 319 ? -29.99309 -15.56669 -35.36225 0.503 29.89906 ? 1778 LYS A HE3  1 
ATOM   5206 H  HE3  B LYS A 1 319 ? -28.38214 -18.80611 -36.54538 0.497 32.92151 ? 1778 LYS A HE3  1 
ATOM   5207 H  HZ1  A LYS A 1 319 ? -30.35581 -16.19089 -37.51900 0.503 31.80660 ? 1778 LYS A HZ1  1 
ATOM   5208 H  HZ1  B LYS A 1 319 ? -27.57196 -17.92658 -38.49845 0.497 34.53852 ? 1778 LYS A HZ1  1 
ATOM   5209 H  HZ2  A LYS A 1 319 ? -29.12641 -15.42666 -37.46569 0.503 31.80660 ? 1778 LYS A HZ2  1 
ATOM   5210 H  HZ2  B LYS A 1 319 ? -28.65499 -17.08450 -38.03341 0.497 34.53852 ? 1778 LYS A HZ2  1 
ATOM   5211 H  HZ3  A LYS A 1 319 ? -29.07777 -16.86912 -37.58930 0.503 31.80660 ? 1778 LYS A HZ3  1 
ATOM   5212 H  HZ3  B LYS A 1 319 ? -27.28122 -16.65834 -37.86177 0.497 34.53852 ? 1778 LYS A HZ3  1 
ATOM   5213 N  N    . VAL A 1 320 ? -24.44706 -19.33678 -31.70054 1.000 15.36743 ? 1779 VAL A N    1 
ATOM   5214 C  CA   . VAL A 1 320 ? -23.09472 -19.67956 -31.31574 1.000 14.48047 ? 1779 VAL A CA   1 
ATOM   5215 C  C    . VAL A 1 320 ? -22.46785 -20.53512 -32.40335 1.000 15.94115 ? 1779 VAL A C    1 
ATOM   5216 O  O    . VAL A 1 320 ? -23.14157 -21.12405 -33.24557 1.000 17.80181 ? 1779 VAL A O    1 
ATOM   5217 C  CB   . VAL A 1 320 ? -23.02265 -20.33322 -29.92993 1.000 13.73048 ? 1779 VAL A CB   1 
ATOM   5218 C  CG1  . VAL A 1 320 ? -23.32952 -19.34691 -28.83548 1.000 16.00426 ? 1779 VAL A CG1  1 
ATOM   5219 C  CG2  . VAL A 1 320 ? -23.91611 -21.55568 -29.83608 1.000 16.30690 ? 1779 VAL A CG2  1 
ATOM   5220 H  H    . VAL A 1 320 ? -24.91830 -20.02648 -31.90510 1.000 18.44091 ? 1779 VAL A H    1 
ATOM   5221 H  HA   . VAL A 1 320 ? -22.55921 -18.87240 -31.26455 1.000 17.37657 ? 1779 VAL A HA   1 
ATOM   5222 H  HB   . VAL A 1 320 ? -22.11038 -20.63577 -29.79907 1.000 16.47658 ? 1779 VAL A HB   1 
ATOM   5223 H  HG11 . VAL A 1 320 ? -23.27569 -19.79882 -27.97888 1.000 19.20511 ? 1779 VAL A HG11 1 
ATOM   5224 H  HG12 . VAL A 1 320 ? -22.68222 -18.62531 -28.87004 1.000 19.20511 ? 1779 VAL A HG12 1 
ATOM   5225 H  HG13 . VAL A 1 320 ? -24.22385 -18.99567 -28.96854 1.000 19.20511 ? 1779 VAL A HG13 1 
ATOM   5226 H  HG21 . VAL A 1 320 ? -23.82370 -21.94737 -28.95350 1.000 19.56828 ? 1779 VAL A HG21 1 
ATOM   5227 H  HG22 . VAL A 1 320 ? -24.83621 -21.28645 -29.98380 1.000 19.56828 ? 1779 VAL A HG22 1 
ATOM   5228 H  HG23 . VAL A 1 320 ? -23.64638 -22.19664 -30.51233 1.000 19.56828 ? 1779 VAL A HG23 1 
ATOM   5229 N  N    . LYS A 1 321 ? -21.14410 -20.58124 -32.36854 1.000 16.48865 ? 1780 LYS A N    1 
ATOM   5230 C  CA   . LYS A 1 321 ? -20.37619 -21.33167 -33.33479 1.000 18.38625 ? 1780 LYS A CA   1 
ATOM   5231 C  C    . LYS A 1 321 ? -19.27198 -21.96003 -32.52023 1.000 17.14394 ? 1780 LYS A C    1 
ATOM   5232 O  O    . LYS A 1 321 ? -18.43115 -21.25552 -31.92888 1.000 17.80982 ? 1780 LYS A O    1 
ATOM   5233 C  CB   . LYS A 1 321 ? -19.81934 -20.43666 -34.44945 1.000 24.76579 ? 1780 LYS A CB   1 
ATOM   5234 C  CG   . LYS A 1 321 ? -19.12000 -21.22429 -35.55094 1.000 27.87411 ? 1780 LYS A CG   1 
ATOM   5235 C  CD   . LYS A 1 321 ? -18.46443 -20.29894 -36.59485 1.000 29.82171 ? 1780 LYS A CD   1 
ATOM   5236 C  CE   . LYS A 1 321 ? -19.20995 -20.30777 -37.91475 1.000 31.69561 ? 1780 LYS A CE   1 
ATOM   5237 N  NZ   . LYS A 1 321 ? -18.93777 -21.56877 -38.70936 1.000 32.32992 ? 1780 LYS A NZ   1 
ATOM   5238 H  H    . LYS A 1 321 ? -20.66329 -20.17657 -31.78147 1.000 19.78638 ? 1780 LYS A H    1 
ATOM   5239 H  HA   . LYS A 1 321 ? -20.90872 -22.00796 -33.78194 1.000 22.06350 ? 1780 LYS A HA   1 
ATOM   5240 H  HB2  . LYS A 1 321 ? -20.55102 -19.94344 -34.85229 1.000 29.71894 ? 1780 LYS A HB2  1 
ATOM   5241 H  HB3  . LYS A 1 321 ? -19.17521 -19.82077 -34.06648 1.000 29.71894 ? 1780 LYS A HB3  1 
ATOM   5242 H  HG2  . LYS A 1 321 ? -18.42622 -21.77644 -35.15762 1.000 33.44893 ? 1780 LYS A HG2  1 
ATOM   5243 H  HG3  . LYS A 1 321 ? -19.76968 -21.78225 -36.00644 1.000 33.44893 ? 1780 LYS A HG3  1 
ATOM   5244 H  HD2  . LYS A 1 321 ? -18.45960 -19.38981 -36.25669 1.000 35.78605 ? 1780 LYS A HD2  1 
ATOM   5245 H  HD3  . LYS A 1 321 ? -17.55597 -20.59667 -36.75902 1.000 35.78605 ? 1780 LYS A HD3  1 
ATOM   5246 H  HE2  . LYS A 1 321 ? -20.16337 -20.25698 -37.74358 1.000 38.03473 ? 1780 LYS A HE2  1 
ATOM   5247 H  HE3  . LYS A 1 321 ? -18.92737 -19.54728 -38.44646 1.000 38.03473 ? 1780 LYS A HE3  1 
ATOM   5248 H  HZ1  . LYS A 1 321 ? -19.39186 -21.55033 -39.47457 1.000 38.79590 ? 1780 LYS A HZ1  1 
ATOM   5249 H  HZ2  . LYS A 1 321 ? -18.06878 -21.63271 -38.89064 1.000 38.79590 ? 1780 LYS A HZ2  1 
ATOM   5250 H  HZ3  . LYS A 1 321 ? -19.18862 -22.28329 -38.24178 1.000 38.79590 ? 1780 LYS A HZ3  1 
ATOM   5251 N  N    . GLY A 1 322 ? -19.29649 -23.27004 -32.46787 1.000 17.78608 ? 1781 GLY A N    1 
ATOM   5252 C  CA   . GLY A 1 322 ? -18.39266 -24.06710 -31.60395 1.000 17.61765 ? 1781 GLY A CA   1 
ATOM   5253 C  C    . GLY A 1 322 ? -19.18052 -24.93204 -30.63537 1.000 16.00436 ? 1781 GLY A C    1 
ATOM   5254 O  O    . GLY A 1 322 ? -20.15051 -24.53791 -30.00470 1.000 16.94388 ? 1781 GLY A O    1 
ATOM   5255 H  H    . GLY A 1 322 ? -19.83549 -23.75695 -32.92830 1.000 21.34330 ? 1781 GLY A H    1 
ATOM   5256 H  HA2  . GLY A 1 322 ? -17.83914 -24.64290 -32.15439 1.000 21.14118 ? 1781 GLY A HA2  1 
ATOM   5257 H  HA3  . GLY A 1 322 ? -17.82050 -23.47250 -31.09406 1.000 21.14118 ? 1781 GLY A HA3  1 
ATOM   5258 N  N    . THR A 1 323 ? -18.75862 -26.18681 -30.54678 1.000 14.24366 ? 1782 THR A N    1 
ATOM   5259 C  CA   A THR A 1 323 ? -19.41763 -27.12920 -29.67784 0.685 15.00683 ? 1782 THR A CA   1 
ATOM   5260 C  CA   B THR A 1 323 ? -19.45695 -27.24827 -29.82638 0.315 13.68300 ? 1782 THR A CA   1 
ATOM   5261 C  C    . THR A 1 323 ? -18.44072 -28.18015 -29.17533 1.000 13.94883 ? 1782 THR A C    1 
ATOM   5262 O  O    . THR A 1 323 ? -17.45808 -28.53189 -29.84012 1.000 14.28303 ? 1782 THR A O    1 
ATOM   5263 C  CB   A THR A 1 323 ? -20.62771 -27.76033 -30.35454 0.685 17.68603 ? 1782 THR A CB   1 
ATOM   5264 C  CB   B THR A 1 323 ? -20.25732 -28.08517 -30.83812 0.315 13.75930 ? 1782 THR A CB   1 
ATOM   5265 O  OG1  A THR A 1 323 ? -21.52123 -28.23159 -29.34191 0.685 19.85730 ? 1782 THR A OG1  1 
ATOM   5266 O  OG1  B THR A 1 323 ? -21.08011 -27.21963 -31.62370 0.315 13.46452 ? 1782 THR A OG1  1 
ATOM   5267 C  CG2  A THR A 1 323 ? -20.18321 -28.88860 -31.26787 0.685 16.65705 ? 1782 THR A CG2  1 
ATOM   5268 C  CG2  B THR A 1 323 ? -21.12108 -29.14610 -30.14769 0.315 13.83298 ? 1782 THR A CG2  1 
ATOM   5269 H  H    A THR A 1 323 ? -18.09162 -26.50984 -30.98308 0.685 17.09239 ? 1782 THR A H    1 
ATOM   5270 H  H    B THR A 1 323 ? -18.03259 -26.46564 -30.91384 0.315 17.09239 ? 1782 THR A H    1 
ATOM   5271 H  HA   A THR A 1 323 ? -19.72836 -26.66107 -28.88714 0.685 18.00819 ? 1782 THR A HA   1 
ATOM   5272 H  HA   B THR A 1 323 ? -20.02224 -26.86484 -29.13767 0.315 16.41961 ? 1782 THR A HA   1 
ATOM   5273 H  HB   A THR A 1 323 ? -21.09677 -27.11553 -30.90691 0.685 21.22324 ? 1782 THR A HB   1 
ATOM   5274 H  HB   B THR A 1 323 ? -19.63759 -28.55870 -31.41484 0.315 16.51117 ? 1782 THR A HB   1 
ATOM   5275 H  HG1  A THR A 1 323 ? -21.13269 -28.79586 -28.85587 0.685 23.82876 ? 1782 THR A HG1  1 
ATOM   5276 H  HG1  B THR A 1 323 ? -21.62537 -26.81480 -31.12933 0.315 16.15743 ? 1782 THR A HG1  1 
ATOM   5277 H  HG21 A THR A 1 323 ? -20.88098 -29.08919 -31.91112 0.685 19.98846 ? 1782 THR A HG21 1 
ATOM   5278 H  HG21 B THR A 1 323 ? -21.69097 -29.58486 -30.79854 0.315 16.59958 ? 1782 THR A HG21 1 
ATOM   5279 H  HG22 A THR A 1 323 ? -19.37911 -28.63149 -31.74560 0.685 19.98846 ? 1782 THR A HG22 1 
ATOM   5280 H  HG22 B THR A 1 323 ? -20.55520 -29.81130 -29.72558 0.315 16.59958 ? 1782 THR A HG22 1 
ATOM   5281 H  HG23 A THR A 1 323 ? -19.99812 -29.68481 -30.74566 0.685 19.98846 ? 1782 THR A HG23 1 
ATOM   5282 H  HG23 B THR A 1 323 ? -21.67804 -28.73117 -29.47055 0.315 16.59958 ? 1782 THR A HG23 1 
ATOM   5283 N  N    . VAL A 1 324 ? -18.72164 -28.65202 -27.96420 1.000 13.66984 ? 1783 VAL A N    1 
ATOM   5284 C  CA   . VAL A 1 324 ? -17.96016 -29.74524 -27.35179 1.000 13.43829 ? 1783 VAL A CA   1 
ATOM   5285 C  C    . VAL A 1 324 ? -18.41229 -31.07120 -27.93898 1.000 13.39089 ? 1783 VAL A C    1 
ATOM   5286 O  O    . VAL A 1 324 ? -19.60717 -31.41421 -27.87751 1.000 15.10148 ? 1783 VAL A O    1 
ATOM   5287 C  CB   . VAL A 1 324 ? -18.15934 -29.75726 -25.83866 1.000 14.70421 ? 1783 VAL A CB   1 
ATOM   5288 C  CG1  . VAL A 1 324 ? -17.44816 -30.90659 -25.18298 1.000 16.34376 ? 1783 VAL A CG1  1 
ATOM   5289 C  CG2  . VAL A 1 324 ? -17.67233 -28.41017 -25.27183 1.000 15.58579 ? 1783 VAL A CG2  1 
ATOM   5290 H  H    . VAL A 1 324 ? -19.35689 -28.35396 -27.46698 1.000 16.40381 ? 1783 VAL A H    1 
ATOM   5291 H  HA   . VAL A 1 324 ? -17.02112 -29.61972 -27.56000 1.000 16.12595 ? 1783 VAL A HA   1 
ATOM   5292 H  HB   . VAL A 1 324 ? -19.10127 -29.87723 -25.64048 1.000 17.64505 ? 1783 VAL A HB   1 
ATOM   5293 H  HG11 . VAL A 1 324 ? -17.42979 -30.76098 -24.22414 1.000 19.61252 ? 1783 VAL A HG11 1 
ATOM   5294 H  HG12 . VAL A 1 324 ? -17.92343 -31.72799 -25.38377 1.000 19.61252 ? 1783 VAL A HG12 1 
ATOM   5295 H  HG13 . VAL A 1 324 ? -16.54273 -30.95564 -25.52750 1.000 19.61252 ? 1783 VAL A HG13 1 
ATOM   5296 H  HG21 . VAL A 1 324 ? -17.71023 -28.44294 -24.30313 1.000 18.70295 ? 1783 VAL A HG21 1 
ATOM   5297 H  HG22 . VAL A 1 324 ? -16.75959 -28.25685 -25.56216 1.000 18.70295 ? 1783 VAL A HG22 1 
ATOM   5298 H  HG23 . VAL A 1 324 ? -18.24767 -27.70227 -25.60161 1.000 18.70295 ? 1783 VAL A HG23 1 
ATOM   5299 N  N    . ARG A 1 325 ? -17.46634 -31.81900 -28.51665 1.000 13.42771 ? 1784 ARG A N    1 
ATOM   5300 C  CA   . ARG A 1 325 ? -17.75406 -33.12342 -29.10145 1.000 13.79096 ? 1784 ARG A CA   1 
ATOM   5301 C  C    . ARG A 1 325 ? -17.39700 -34.25986 -28.16502 1.000 14.03832 ? 1784 ARG A C    1 
ATOM   5302 O  O    . ARG A 1 325 ? -18.13524 -35.24123 -28.06316 1.000 15.76473 ? 1784 ARG A O    1 
ATOM   5303 C  CB   . ARG A 1 325 ? -17.04080 -33.31147 -30.44139 1.000 15.60424 ? 1784 ARG A CB   1 
ATOM   5304 C  CG   . ARG A 1 325 ? -17.37972 -32.31949 -31.52384 1.000 17.91245 ? 1784 ARG A CG   1 
ATOM   5305 C  CD   . ARG A 1 325 ? -18.81098 -32.34318 -31.93320 1.000 19.55214 ? 1784 ARG A CD   1 
ATOM   5306 N  NE   . ARG A 1 325 ? -19.23327 -33.64973 -32.40744 1.000 21.88660 ? 1784 ARG A NE   1 
ATOM   5307 C  CZ   . ARG A 1 325 ? -19.02611 -34.13076 -33.61522 1.000 24.89488 ? 1784 ARG A CZ   1 
ATOM   5308 N  NH1  . ARG A 1 325 ? -18.37321 -33.42382 -34.54038 1.000 26.28966 ? 1784 ARG A NH1  1 
ATOM   5309 N  NH2  . ARG A 1 325 ? -19.53227 -35.33849 -33.92223 1.000 27.27926 ? 1784 ARG A NH2  1 
ATOM   5310 H  H    . ARG A 1 325 ? -16.64119 -31.58528 -28.58067 1.000 16.11326 ? 1784 ARG A H    1 
ATOM   5311 H  HA   . ARG A 1 325 ? -18.70357 -33.16987 -29.29428 1.000 16.54916 ? 1784 ARG A HA   1 
ATOM   5312 H  HB2  . ARG A 1 325 ? -16.08537 -33.24866 -30.28611 1.000 18.72508 ? 1784 ARG A HB2  1 
ATOM   5313 H  HB3  . ARG A 1 325 ? -17.26448 -34.19196 -30.78138 1.000 18.72508 ? 1784 ARG A HB3  1 
ATOM   5314 H  HG2  . ARG A 1 325 ? -17.17920 -31.42627 -31.20316 1.000 21.49494 ? 1784 ARG A HG2  1 
ATOM   5315 H  HG3  . ARG A 1 325 ? -16.84501 -32.51814 -32.30840 1.000 21.49494 ? 1784 ARG A HG3  1 
ATOM   5316 H  HD2  . ARG A 1 325 ? -19.36269 -32.10726 -31.17106 1.000 23.46257 ? 1784 ARG A HD2  1 
ATOM   5317 H  HD3  . ARG A 1 325 ? -18.94611 -31.70477 -32.65088 1.000 23.46257 ? 1784 ARG A HD3  1 
ATOM   5318 H  HE   . ARG A 1 325 ? -19.65490 -34.15224 -31.85129 1.000 26.26392 ? 1784 ARG A HE   1 
ATOM   5319 H  HH11 . ARG A 1 325 ? -18.07869 -32.63797 -34.35248 1.000 31.54759 ? 1784 ARG A HH11 1 
ATOM   5320 H  HH12 . ARG A 1 325 ? -18.24711 -33.75421 -35.32430 1.000 31.54759 ? 1784 ARG A HH12 1 
ATOM   5321 H  HH21 . ARG A 1 325 ? -19.98020 -35.77894 -33.33490 1.000 32.73511 ? 1784 ARG A HH21 1 
ATOM   5322 H  HH22 . ARG A 1 325 ? -19.40799 -35.67025 -34.70587 1.000 32.73511 ? 1784 ARG A HH22 1 
ATOM   5323 N  N    . ARG A 1 326 ? -16.24159 -34.19590 -27.53107 1.000 13.20930 ? 1785 ARG A N    1 
ATOM   5324 C  CA   . ARG A 1 326 ? -15.75593 -35.30781 -26.72192 1.000 14.13571 ? 1785 ARG A CA   1 
ATOM   5325 C  C    . ARG A 1 326 ? -14.92122 -34.76731 -25.59246 1.000 13.24350 ? 1785 ARG A C    1 
ATOM   5326 O  O    . ARG A 1 326 ? -14.15808 -33.80982 -25.80323 1.000 14.91199 ? 1785 ARG A O    1 
ATOM   5327 C  CB   . ARG A 1 326 ? -14.96275 -36.32079 -27.56519 1.000 16.28865 ? 1785 ARG A CB   1 
ATOM   5328 C  CG   . ARG A 1 326 ? -14.83249 -37.67900 -26.94163 1.000 21.00485 ? 1785 ARG A CG   1 
ATOM   5329 C  CD   . ARG A 1 326 ? -14.28508 -38.69207 -27.95420 1.000 24.47368 ? 1785 ARG A CD   1 
ATOM   5330 N  NE   . ARG A 1 326 ? -12.86849 -38.43998 -28.15597 1.000 26.07649 ? 1785 ARG A NE   1 
ATOM   5331 C  CZ   . ARG A 1 326 ? -11.88729 -39.23366 -27.75085 1.000 25.95555 ? 1785 ARG A CZ   1 
ATOM   5332 N  NH1  . ARG A 1 326 ? -12.12301 -40.43947 -27.26058 1.000 26.58183 ? 1785 ARG A NH1  1 
ATOM   5333 N  NH2  . ARG A 1 326 ? -10.62872 -38.79459 -27.83866 1.000 27.15563 ? 1785 ARG A NH2  1 
ATOM   5334 H  H    . ARG A 1 326 ? -15.71362 -33.51733 -27.55082 1.000 15.85116 ? 1785 ARG A H    1 
ATOM   5335 H  HA   . ARG A 1 326 ? -16.50758 -35.78027 -26.33114 1.000 16.96285 ? 1785 ARG A HA   1 
ATOM   5336 H  HB2  . ARG A 1 326 ? -15.41103 -36.43136 -28.41825 1.000 19.54638 ? 1785 ARG A HB2  1 
ATOM   5337 H  HB3  . ARG A 1 326 ? -14.06734 -35.97431 -27.70340 1.000 19.54638 ? 1785 ARG A HB3  1 
ATOM   5338 H  HG2  . ARG A 1 326 ? -14.22069 -37.63332 -26.19029 1.000 25.20582 ? 1785 ARG A HG2  1 
ATOM   5339 H  HG3  . ARG A 1 326 ? -15.70358 -37.98298 -26.64215 1.000 25.20582 ? 1785 ARG A HG3  1 
ATOM   5340 H  HD2  . ARG A 1 326 ? -14.40007 -39.59358 -27.61515 1.000 29.36842 ? 1785 ARG A HD2  1 
ATOM   5341 H  HD3  . ARG A 1 326 ? -14.74679 -38.59496 -28.80172 1.000 29.36842 ? 1785 ARG A HD3  1 
ATOM   5342 H  HE   . ARG A 1 326 ? -12.64944 -37.71920 -28.57082 1.000 31.29179 ? 1785 ARG A HE   1 
ATOM   5343 H  HH11 . ARG A 1 326 ? -12.93081 -40.72779 -27.19784 1.000 31.89819 ? 1785 ARG A HH11 1 
ATOM   5344 H  HH12 . ARG A 1 326 ? -11.46845 -40.93507 -27.00457 1.000 31.89819 ? 1785 ARG A HH12 1 
ATOM   5345 H  HH21 . ARG A 1 326 ? -10.46779 -38.01058 -28.15333 1.000 32.58676 ? 1785 ARG A HH21 1 
ATOM   5346 H  HH22 . ARG A 1 326 ? -9.97941  -39.29595 -27.58053 1.000 32.58676 ? 1785 ARG A HH22 1 
ATOM   5347 N  N    . VAL A 1 327 ? -15.01888 -35.38262 -24.43743 1.000 11.97758 ? 1786 VAL A N    1 
ATOM   5348 C  CA   . VAL A 1 327 ? -14.18105 -35.10322 -23.28178 1.000 11.51699 ? 1786 VAL A CA   1 
ATOM   5349 C  C    . VAL A 1 327 ? -13.64136 -36.43479 -22.77677 1.000 11.92231 ? 1786 VAL A C    1 
ATOM   5350 O  O    . VAL A 1 327 ? -14.40791 -37.39283 -22.57026 1.000 14.06192 ? 1786 VAL A O    1 
ATOM   5351 C  CB   . VAL A 1 327 ? -14.97004 -34.43054 -22.15962 1.000 12.67487 ? 1786 VAL A CB   1 
ATOM   5352 C  CG1  . VAL A 1 327 ? -14.09212 -34.15796 -20.93472 1.000 12.12752 ? 1786 VAL A CG1  1 
ATOM   5353 C  CG2  . VAL A 1 327 ? -15.62139 -33.13977 -22.67255 1.000 12.20915 ? 1786 VAL A CG2  1 
ATOM   5354 H  H    . VAL A 1 327 ? -15.59439 -36.00283 -24.28337 1.000 14.37309 ? 1786 VAL A H    1 
ATOM   5355 H  HA   . VAL A 1 327 ? -13.44872 -34.52498 -23.54680 1.000 13.82039 ? 1786 VAL A HA   1 
ATOM   5356 H  HB   . VAL A 1 327 ? -15.67183 -35.03523 -21.87198 1.000 15.20984 ? 1786 VAL A HB   1 
ATOM   5357 H  HG11 . VAL A 1 327 ? -14.58043 -33.59303 -20.31561 1.000 14.55302 ? 1786 VAL A HG11 1 
ATOM   5358 H  HG12 . VAL A 1 327 ? -13.87230 -35.00171 -20.50967 1.000 14.55302 ? 1786 VAL A HG12 1 
ATOM   5359 H  HG13 . VAL A 1 327 ? -13.28053 -33.71053 -21.22112 1.000 14.55302 ? 1786 VAL A HG13 1 
ATOM   5360 H  HG21 . VAL A 1 327 ? -16.05644 -32.68956 -21.93165 1.000 14.65098 ? 1786 VAL A HG21 1 
ATOM   5361 H  HG22 . VAL A 1 327 ? -14.93476 -32.56791 -23.04993 1.000 14.65098 ? 1786 VAL A HG22 1 
ATOM   5362 H  HG23 . VAL A 1 327 ? -16.27523 -33.36472 -23.35285 1.000 14.65098 ? 1786 VAL A HG23 1 
ATOM   5363 N  N    . VAL A 1 328 ? -12.32661 -36.47693 -22.55162 1.000 12.76445 ? 1787 VAL A N    1 
ATOM   5364 C  CA   . VAL A 1 328 ? -11.64894 -37.59129 -21.91568 1.000 13.65926 ? 1787 VAL A CA   1 
ATOM   5365 C  C    . VAL A 1 328 ? -11.13363 -37.09380 -20.57772 1.000 12.28810 ? 1787 VAL A C    1 
ATOM   5366 O  O    . VAL A 1 328 ? -10.48187 -36.04623 -20.53509 1.000 12.53021 ? 1787 VAL A O    1 
ATOM   5367 C  CB   . VAL A 1 328 ? -10.51792 -38.12302 -22.81291 1.000 13.98565 ? 1787 VAL A CB   1 
ATOM   5368 C  CG1  . VAL A 1 328 ? -9.64281  -39.16138 -22.07218 1.000 14.77783 ? 1787 VAL A CG1  1 
ATOM   5369 C  CG2  . VAL A 1 328 ? -11.10134 -38.66509 -24.11533 1.000 14.77781 ? 1787 VAL A CG2  1 
ATOM   5370 H  H    . VAL A 1 328 ? -11.79001 -35.84144 -22.77028 1.000 15.31734 ? 1787 VAL A H    1 
ATOM   5371 H  HA   . VAL A 1 328 ? -12.26194 -38.32454 -21.74993 1.000 16.39111 ? 1787 VAL A HA   1 
ATOM   5372 H  HB   . VAL A 1 328 ? -9.91999  -37.39426 -23.04159 1.000 16.78278 ? 1787 VAL A HB   1 
ATOM   5373 H  HG11 . VAL A 1 328 ? -9.06262  -39.60046 -22.71366 1.000 17.73340 ? 1787 VAL A HG11 1 
ATOM   5374 H  HG12 . VAL A 1 328 ? -9.10990  -38.70493 -21.40244 1.000 17.73340 ? 1787 VAL A HG12 1 
ATOM   5375 H  HG13 . VAL A 1 328 ? -10.21992 -39.81473 -21.64677 1.000 17.73340 ? 1787 VAL A HG13 1 
ATOM   5376 H  HG21 . VAL A 1 328 ? -10.38392 -39.03638 -24.65233 1.000 17.73337 ? 1787 VAL A HG21 1 
ATOM   5377 H  HG22 . VAL A 1 328 ? -11.75027 -39.35543 -23.90748 1.000 17.73337 ? 1787 VAL A HG22 1 
ATOM   5378 H  HG23 . VAL A 1 328 ? -11.53188 -37.93986 -24.59447 1.000 17.73337 ? 1787 VAL A HG23 1 
ATOM   5379 N  N    . LEU A 1 329 ? -11.44085 -37.80775 -19.48840 1.000 12.21700 ? 1788 LEU A N    1 
ATOM   5380 C  CA   . LEU A 1 329 ? -11.03797 -37.42953 -18.14863 1.000 12.16961 ? 1788 LEU A CA   1 
ATOM   5381 C  C    . LEU A 1 329 ? -10.24728 -38.58283 -17.54744 1.000 11.61173 ? 1788 LEU A C    1 
ATOM   5382 O  O    . LEU A 1 329 ? -10.81679 -39.67271 -17.33926 1.000 12.51703 ? 1788 LEU A O    1 
ATOM   5383 C  CB   . LEU A 1 329 ? -12.22166 -37.05271 -17.25890 1.000 12.25124 ? 1788 LEU A CB   1 
ATOM   5384 C  CG   . LEU A 1 329 ? -11.86376 -36.77046 -15.80396 1.000 12.45396 ? 1788 LEU A CG   1 
ATOM   5385 C  CD1  . LEU A 1 329 ? -10.79123 -35.66153 -15.68511 1.000 13.24869 ? 1788 LEU A CD1  1 
ATOM   5386 C  CD2  . LEU A 1 329 ? -13.09721 -36.35700 -15.04950 1.000 13.24074 ? 1788 LEU A CD2  1 
ATOM   5387 H  H    . LEU A 1 329 ? -11.89668 -38.53664 -19.51127 1.000 14.66039 ? 1788 LEU A H    1 
ATOM   5388 H  HA   . LEU A 1 329 ? -10.46831 -36.64619 -18.20129 1.000 14.60354 ? 1788 LEU A HA   1 
ATOM   5389 H  HB2  . LEU A 1 329 ? -12.63396 -36.25201 -17.61916 1.000 14.70149 ? 1788 LEU A HB2  1 
ATOM   5390 H  HB3  . LEU A 1 329 ? -12.85723 -37.78543 -17.26677 1.000 14.70149 ? 1788 LEU A HB3  1 
ATOM   5391 H  HG   . LEU A 1 329 ? -11.49719 -37.58038 -15.41593 1.000 14.94475 ? 1788 LEU A HG   1 
ATOM   5392 H  HD11 . LEU A 1 329 ? -10.68472 -35.42406 -14.75067 1.000 15.89843 ? 1788 LEU A HD11 1 
ATOM   5393 H  HD12 . LEU A 1 329 ? -9.95197  -35.99462 -16.03949 1.000 15.89843 ? 1788 LEU A HD12 1 
ATOM   5394 H  HD13 . LEU A 1 329 ? -11.08031 -34.88693 -16.19238 1.000 15.89843 ? 1788 LEU A HD13 1 
ATOM   5395 H  HD21 . LEU A 1 329 ? -12.85836 -36.18102 -14.12598 1.000 15.88889 ? 1788 LEU A HD21 1 
ATOM   5396 H  HD22 . LEU A 1 329 ? -13.46172 -35.55500 -15.45548 1.000 15.88889 ? 1788 LEU A HD22 1 
ATOM   5397 H  HD23 . LEU A 1 329 ? -13.74859 -37.07451 -15.09174 1.000 15.88889 ? 1788 LEU A HD23 1 
ATOM   5398 N  N    . ARG A 1 330 ? -8.97964  -38.35611 -17.27846 1.000 12.57755 ? 1789 ARG A N    1 
ATOM   5399 C  CA   . ARG A 1 330 ? -8.12533  -39.38310 -16.67111 1.000 12.59862 ? 1789 ARG A CA   1 
ATOM   5400 C  C    . ARG A 1 330 ? -8.24615  -40.73401 -17.38886 1.000 13.12771 ? 1789 ARG A C    1 
ATOM   5401 O  O    . ARG A 1 330 ? -8.39872  -41.81530 -16.77204 1.000 14.44618 ? 1789 ARG A O    1 
ATOM   5402 C  CB   . ARG A 1 330 ? -8.32930  -39.46100 -15.17546 1.000 11.25644 ? 1789 ARG A CB   1 
ATOM   5403 C  CG   . ARG A 1 330 ? -7.79383  -38.20516 -14.45553 1.000 12.24592 ? 1789 ARG A CG   1 
ATOM   5404 C  CD   . ARG A 1 330 ? -7.96919  -38.25581 -12.95457 1.000 12.95653 ? 1789 ARG A CD   1 
ATOM   5405 N  NE   . ARG A 1 330 ? -9.34566  -38.04002 -12.53198 1.000 12.63813 ? 1789 ARG A NE   1 
ATOM   5406 C  CZ   . ARG A 1 330 ? -10.21489 -38.99324 -12.22767 1.000 12.88023 ? 1789 ARG A CZ   1 
ATOM   5407 N  NH1  . ARG A 1 330 ? -9.89910  -40.27628 -12.36664 1.000 13.65926 ? 1789 ARG A NH1  1 
ATOM   5408 N  NH2  . ARG A 1 330 ? -11.43946 -38.64909 -11.81149 1.000 13.64616 ? 1789 ARG A NH2  1 
ATOM   5409 H  H    . ARG A 1 330 ? -8.57706  -37.61257 -17.43555 1.000 15.09306 ? 1789 ARG A H    1 
ATOM   5410 H  HA   . ARG A 1 330 ? -7.19999  -39.12059 -16.79654 1.000 15.11835 ? 1789 ARG A HA   1 
ATOM   5411 H  HB2  . ARG A 1 330 ? -9.27753  -39.53874 -14.98644 1.000 13.50773 ? 1789 ARG A HB2  1 
ATOM   5412 H  HB3  . ARG A 1 330 ? -7.85746  -40.23447 -14.82902 1.000 13.50773 ? 1789 ARG A HB3  1 
ATOM   5413 H  HG2  . ARG A 1 330 ? -6.84591  -38.11649 -14.64119 1.000 14.69510 ? 1789 ARG A HG2  1 
ATOM   5414 H  HG3  . ARG A 1 330 ? -8.27051  -37.42699 -14.78436 1.000 14.69510 ? 1789 ARG A HG3  1 
ATOM   5415 H  HD2  . ARG A 1 330 ? -7.69238  -39.12864 -12.63452 1.000 15.54784 ? 1789 ARG A HD2  1 
ATOM   5416 H  HD3  . ARG A 1 330 ? -7.42134  -37.56505 -12.55009 1.000 15.54784 ? 1789 ARG A HD3  1 
ATOM   5417 H  HE   . ARG A 1 330 ? -9.61741  -37.22608 -12.47506 1.000 15.16576 ? 1789 ARG A HE   1 
ATOM   5418 H  HH11 . ARG A 1 330 ? -9.12099  -40.49851 -12.65781 1.000 16.39111 ? 1789 ARG A HH11 1 
ATOM   5419 H  HH12 . ARG A 1 330 ? -10.47279 -40.88455 -12.16544 1.000 16.39111 ? 1789 ARG A HH12 1 
ATOM   5420 H  HH21 . ARG A 1 330 ? -11.65332 -37.81880 -11.74453 1.000 16.37539 ? 1789 ARG A HH21 1 
ATOM   5421 H  HH22 . ARG A 1 330 ? -12.01248 -39.25823 -11.61102 1.000 16.37539 ? 1789 ARG A HH22 1 
ATOM   5422 N  N    . GLY A 1 331 ? -8.19900  -40.65891 -18.72999 1.000 13.55668 ? 1790 GLY A N    1 
ATOM   5423 C  CA   . GLY A 1 331 ? -8.13167  -41.83041 -19.57362 1.000 14.23300 ? 1790 GLY A CA   1 
ATOM   5424 C  C    . GLY A 1 331 ? -9.45008  -42.48036 -19.90307 1.000 15.35693 ? 1790 GLY A C    1 
ATOM   5425 O  O    . GLY A 1 331 ? -9.45826  -43.48231 -20.63039 1.000 19.77825 ? 1790 GLY A O    1 
ATOM   5426 H  H    . GLY A 1 331 ? -8.20563  -39.91981 -19.16964 1.000 16.26801 ? 1790 GLY A H    1 
ATOM   5427 H  HA2  . GLY A 1 331 ? -7.71237  -41.58069 -20.41191 1.000 17.07961 ? 1790 GLY A HA2  1 
ATOM   5428 H  HA3  . GLY A 1 331 ? -7.58144  -42.49550 -19.13112 1.000 17.07961 ? 1790 GLY A HA3  1 
ATOM   5429 N  N    . GLU A 1 332 ? -10.57002 -41.97099 -19.40868 1.000 14.74898 ? 1791 GLU A N    1 
ATOM   5430 C  CA   . GLU A 1 332 ? -11.87780 -42.51684 -19.74180 1.000 14.92528 ? 1791 GLU A CA   1 
ATOM   5431 C  C    . GLU A 1 332 ? -12.69909 -41.51766 -20.53821 1.000 13.99884 ? 1791 GLU A C    1 
ATOM   5432 O  O    . GLU A 1 332 ? -12.68067 -40.30701 -20.26575 1.000 14.44625 ? 1791 GLU A O    1 
ATOM   5433 C  CB   . GLU A 1 332 ? -12.64519 -42.86784 -18.47612 1.000 16.40962 ? 1791 GLU A CB   1 
ATOM   5434 C  CG   . GLU A 1 332 ? -11.94706 -43.94171 -17.60041 1.000 18.14945 ? 1791 GLU A CG   1 
ATOM   5435 C  CD   . GLU A 1 332 ? -11.72664 -45.25572 -18.33725 1.000 24.04206 ? 1791 GLU A CD   1 
ATOM   5436 O  OE1  . GLU A 1 332 ? -12.63016 -45.68593 -19.06083 1.000 26.26862 ? 1791 GLU A OE1  1 
ATOM   5437 O  OE2  . GLU A 1 332 ? -10.60738 -45.83281 -18.18007 1.000 26.81602 ? 1791 GLU A OE2  1 
ATOM   5438 H  H    . GLU A 1 332 ? -10.59801 -41.30027 -18.87113 1.000 17.69877 ? 1791 GLU A H    1 
ATOM   5439 H  HA   . GLU A 1 332 ? -11.75200 -43.31027 -20.28543 1.000 17.91034 ? 1791 GLU A HA   1 
ATOM   5440 H  HB2  . GLU A 1 332 ? -12.74433 -42.06622 -17.93903 1.000 19.69154 ? 1791 GLU A HB2  1 
ATOM   5441 H  HB3  . GLU A 1 332 ? -13.51786 -43.21027 -18.72529 1.000 19.69154 ? 1791 GLU A HB3  1 
ATOM   5442 H  HG2  . GLU A 1 332 ? -11.08086 -43.60643 -17.32080 1.000 21.77934 ? 1791 GLU A HG2  1 
ATOM   5443 H  HG3  . GLU A 1 332 ? -12.49909 -44.12308 -16.82371 1.000 21.77934 ? 1791 GLU A HG3  1 
ATOM   5444 N  N    . VAL A 1 333 ? -13.44514 -42.00559 -21.52381 1.000 14.83835 ? 1792 VAL A N    1 
ATOM   5445 C  CA   . VAL A 1 333 ? -14.38757 -41.14944 -22.23278 1.000 14.52788 ? 1792 VAL A CA   1 
ATOM   5446 C  C    . VAL A 1 333 ? -15.45196 -40.69339 -21.25344 1.000 13.71198 ? 1792 VAL A C    1 
ATOM   5447 O  O    . VAL A 1 333 ? -16.18824 -41.52151 -20.68204 1.000 14.81993 ? 1792 VAL A O    1 
ATOM   5448 C  CB   . VAL A 1 333 ? -14.98056 -41.85138 -23.45023 1.000 16.67281 ? 1792 VAL A CB   1 
ATOM   5449 C  CG1  . VAL A 1 333 ? -15.94869 -40.89174 -24.14882 1.000 17.70973 ? 1792 VAL A CG1  1 
ATOM   5450 C  CG2  . VAL A 1 333 ? -13.89314 -42.28471 -24.39149 1.000 17.86761 ? 1792 VAL A CG2  1 
ATOM   5451 H  H    . VAL A 1 333 ? -13.42493 -42.82029 -21.79850 1.000 17.80602 ? 1792 VAL A H    1 
ATOM   5452 H  HA   . VAL A 1 333 ? -13.91708 -40.36774 -22.56213 1.000 17.43346 ? 1792 VAL A HA   1 
ATOM   5453 H  HB   . VAL A 1 333 ? -15.46063 -42.64735 -23.17302 1.000 20.00737 ? 1792 VAL A HB   1 
ATOM   5454 H  HG11 . VAL A 1 333 ? -16.17741 -41.25242 -25.01974 1.000 21.25168 ? 1792 VAL A HG11 1 
ATOM   5455 H  HG12 . VAL A 1 333 ? -16.74872 -40.80100 -23.60788 1.000 21.25168 ? 1792 VAL A HG12 1 
ATOM   5456 H  HG13 . VAL A 1 333 ? -15.51874 -40.02825 -24.25092 1.000 21.25168 ? 1792 VAL A HG13 1 
ATOM   5457 H  HG21 . VAL A 1 333 ? -14.29721 -42.65821 -25.19031 1.000 21.44113 ? 1792 VAL A HG21 1 
ATOM   5458 H  HG22 . VAL A 1 333 ? -13.35129 -41.51451 -24.62404 1.000 21.44113 ? 1792 VAL A HG22 1 
ATOM   5459 H  HG23 . VAL A 1 333 ? -13.34506 -42.95473 -23.95379 1.000 21.44113 ? 1792 VAL A HG23 1 
ATOM   5460 N  N    . ALA A 1 334 ? -15.55061 -39.37764 -21.06767 1.000 13.77773 ? 1793 ALA A N    1 
ATOM   5461 C  CA   . ALA A 1 334 ? -16.47160 -38.82206 -20.09451 1.000 13.51195 ? 1793 ALA A CA   1 
ATOM   5462 C  C    . ALA A 1 334 ? -17.71977 -38.25555 -20.73780 1.000 12.98553 ? 1793 ALA A C    1 
ATOM   5463 O  O    . ALA A 1 334 ? -18.77832 -38.20848 -20.08487 1.000 13.43554 ? 1793 ALA A O    1 
ATOM   5464 C  CB   . ALA A 1 334 ? -15.77495 -37.71837 -19.31390 1.000 14.63305 ? 1793 ALA A CB   1 
ATOM   5465 H  H    . ALA A 1 334 ? -15.09169 -38.79018 -21.49648 1.000 16.53327 ? 1793 ALA A H    1 
ATOM   5466 H  HA   . ALA A 1 334 ? -16.74225 -39.51223 -19.46896 1.000 16.21434 ? 1793 ALA A HA   1 
ATOM   5467 H  HB1  . ALA A 1 334 ? -16.39292 -37.35551 -18.66019 1.000 17.55966 ? 1793 ALA A HB1  1 
ATOM   5468 H  HB2  . ALA A 1 334 ? -14.99940 -38.09006 -18.86526 1.000 17.55966 ? 1793 ALA A HB2  1 
ATOM   5469 H  HB3  . ALA A 1 334 ? -15.49853 -37.02198 -19.92996 1.000 17.55966 ? 1793 ALA A HB3  1 
ATOM   5470 N  N    . TYR A 1 335 ? -17.63388 -37.82692 -21.99179 1.000 13.12765 ? 1794 TYR A N    1 
ATOM   5471 C  CA   . TYR A 1 335 ? -18.72402 -37.15454 -22.69213 1.000 12.97767 ? 1794 TYR A CA   1 
ATOM   5472 C  C    . TYR A 1 335 ? -18.52989 -37.30613 -24.17875 1.000 13.16986 ? 1794 TYR A C    1 
ATOM   5473 O  O    . TYR A 1 335 ? -17.41698 -37.08811 -24.68028 1.000 13.83296 ? 1794 TYR A O    1 
ATOM   5474 C  CB   . TYR A 1 335 ? -18.74227 -35.65167 -22.33727 1.000 13.37236 ? 1794 TYR A CB   1 
ATOM   5475 C  CG   . TYR A 1 335 ? -19.78365 -34.82598 -23.08230 1.000 13.25399 ? 1794 TYR A CG   1 
ATOM   5476 C  CD1  . TYR A 1 335 ? -21.11197 -34.82841 -22.64818 1.000 13.24340 ? 1794 TYR A CD1  1 
ATOM   5477 C  CD2  . TYR A 1 335 ? -19.46770 -34.05994 -24.18879 1.000 13.66720 ? 1794 TYR A CD2  1 
ATOM   5478 C  CE1  . TYR A 1 335 ? -22.05619 -34.05719 -23.29796 1.000 13.25404 ? 1794 TYR A CE1  1 
ATOM   5479 C  CE2  . TYR A 1 335 ? -20.41583 -33.29040 -24.85423 1.000 14.23305 ? 1794 TYR A CE2  1 
ATOM   5480 C  CZ   . TYR A 1 335 ? -21.70926 -33.28553 -24.38685 1.000 13.85936 ? 1794 TYR A CZ   1 
ATOM   5481 O  OH   . TYR A 1 335 ? -22.66433 -32.53166 -25.00023 1.000 16.12266 ? 1794 TYR A OH   1 
ATOM   5482 H  H    . TYR A 1 335 ? -16.92979 -37.91613 -22.47750 1.000 15.75318 ? 1794 TYR A H    1 
ATOM   5483 H  HA   . TYR A 1 335 ? -19.56707 -37.56551 -22.44458 1.000 15.57320 ? 1794 TYR A HA   1 
ATOM   5484 H  HB2  . TYR A 1 335 ? -18.92490 -35.56247 -21.38880 1.000 16.04683 ? 1794 TYR A HB2  1 
ATOM   5485 H  HB3  . TYR A 1 335 ? -17.87186 -35.27687 -22.54420 1.000 16.04683 ? 1794 TYR A HB3  1 
ATOM   5486 H  HD1  . TYR A 1 335 ? -21.36097 -35.35054 -21.91998 1.000 15.89208 ? 1794 TYR A HD1  1 
ATOM   5487 H  HD2  . TYR A 1 335 ? -18.59091 -34.05917 -24.49885 1.000 16.40064 ? 1794 TYR A HD2  1 
ATOM   5488 H  HE1  . TYR A 1 335 ? -22.93629 -34.05847 -22.99742 1.000 15.90485 ? 1794 TYR A HE1  1 
ATOM   5489 H  HE2  . TYR A 1 335 ? -20.17979 -32.78874 -25.60090 1.000 17.07966 ? 1794 TYR A HE2  1 
ATOM   5490 H  HH   . TYR A 1 335 ? -22.32608 -32.10342 -25.63881 1.000 19.34719 ? 1794 TYR A HH   1 
ATOM   5491 N  N    A ILE A 1 336 ? -19.60964 -37.59488 -24.91114 0.455 14.06725 ? 1795 ILE A N    1 
ATOM   5492 N  N    B ILE A 1 336 ? -19.58735 -37.73248 -24.89790 0.545 13.91198 ? 1795 ILE A N    1 
ATOM   5493 C  CA   A ILE A 1 336 ? -19.50786 -37.63112 -26.36258 0.455 15.10161 ? 1795 ILE A CA   1 
ATOM   5494 C  CA   B ILE A 1 336 ? -19.59948 -37.64930 -26.34725 0.545 14.72264 ? 1795 ILE A CA   1 
ATOM   5495 C  C    A ILE A 1 336 ? -20.85623 -37.25019 -26.95700 0.455 15.68848 ? 1795 ILE A C    1 
ATOM   5496 C  C    B ILE A 1 336 ? -20.94435 -37.12168 -26.78936 0.545 15.18574 ? 1795 ILE A C    1 
ATOM   5497 O  O    A ILE A 1 336 ? -21.84131 -37.98521 -26.82571 0.455 16.14377 ? 1795 ILE A O    1 
ATOM   5498 O  O    B ILE A 1 336 ? -21.99266 -37.70527 -26.47059 0.545 13.81459 ? 1795 ILE A O    1 
ATOM   5499 C  CB   A ILE A 1 336 ? -18.97150 -39.01539 -26.80717 0.455 16.42011 ? 1795 ILE A CB   1 
ATOM   5500 C  CB   B ILE A 1 336 ? -19.40201 -38.99755 -27.06245 0.545 16.42805 ? 1795 ILE A CB   1 
ATOM   5501 C  CG1  A ILE A 1 336 ? -18.69278 -39.08314 -28.31364 0.455 16.44912 ? 1795 ILE A CG1  1 
ATOM   5502 C  CG1  B ILE A 1 336 ? -18.01872 -39.54878 -26.76899 0.545 16.94388 ? 1795 ILE A CG1  1 
ATOM   5503 C  CG2  A ILE A 1 336 ? -19.90312 -40.14503 -26.35075 0.455 15.99643 ? 1795 ILE A CG2  1 
ATOM   5504 C  CG2  B ILE A 1 336 ? -19.59119 -38.82260 -28.56851 0.545 18.15975 ? 1795 ILE A CG2  1 
ATOM   5505 C  CD1  A ILE A 1 336 ? -17.96520 -40.36109 -28.73316 0.455 17.32022 ? 1795 ILE A CD1  1 
ATOM   5506 C  CD1  B ILE A 1 336 ? -17.82110 -40.92724 -27.36835 0.545 16.93074 ? 1795 ILE A CD1  1 
ATOM   5507 H  H    A ILE A 1 336 ? -20.38997 -37.76824 -24.59392 0.455 16.88070 ? 1795 ILE A H    1 
ATOM   5508 H  H    B ILE A 1 336 ? -20.30082 -38.07063 -24.55697 0.545 16.69438 ? 1795 ILE A H    1 
ATOM   5509 H  HA   A ILE A 1 336 ? -18.88312 -36.96928 -26.69811 0.455 18.12193 ? 1795 ILE A HA   1 
ATOM   5510 H  HA   B ILE A 1 336 ? -18.87781 -37.04776 -26.58863 0.545 17.66717 ? 1795 ILE A HA   1 
ATOM   5511 H  HB   A ILE A 1 336 ? -18.11628 -39.13674 -26.36585 0.455 19.70413 ? 1795 ILE A HB   1 
ATOM   5512 H  HB   B ILE A 1 336 ? -20.06360 -39.62498 -26.73150 0.545 19.71366 ? 1795 ILE A HB   1 
ATOM   5513 H  HG12 A ILE A 1 336 ? -19.53641 -39.04926 -28.79118 0.455 19.73895 ? 1795 ILE A HG12 1 
ATOM   5514 H  HG12 B ILE A 1 336 ? -17.35162 -38.95451 -27.14679 0.545 20.33266 ? 1795 ILE A HG12 1 
ATOM   5515 H  HG13 A ILE A 1 336 ? -18.13868 -38.32771 -28.56503 0.455 19.73895 ? 1795 ILE A HG13 1 
ATOM   5516 H  HG13 B ILE A 1 336 ? -17.89856 -39.61471 -25.80873 0.545 20.33266 ? 1795 ILE A HG13 1 
ATOM   5517 H  HG21 A ILE A 1 336 ? -19.40402 -40.97648 -26.32865 0.455 19.19572 ? 1795 ILE A HG21 1 
ATOM   5518 H  HG21 B ILE A 1 336 ? -19.25560 -39.61128 -29.02267 0.545 21.79170 ? 1795 ILE A HG21 1 
ATOM   5519 H  HG22 A ILE A 1 336 ? -20.24022 -39.93794 -25.46510 0.455 19.19572 ? 1795 ILE A HG22 1 
ATOM   5520 H  HG22 B ILE A 1 336 ? -20.53591 -38.70919 -28.75706 0.545 21.79170 ? 1795 ILE A HG22 1 
ATOM   5521 H  HG23 A ILE A 1 336 ? -20.64060 -40.21845 -26.97656 0.455 19.19572 ? 1795 ILE A HG23 1 
ATOM   5522 H  HG23 B ILE A 1 336 ? -19.09937 -38.03886 -28.85963 0.545 21.79170 ? 1795 ILE A HG23 1 
ATOM   5523 H  HD11 A ILE A 1 336 ? -17.19608 -40.49043 -28.15642 0.455 20.78427 ? 1795 ILE A HD11 1 
ATOM   5524 H  HD11 B ILE A 1 336 ? -18.62243 -41.45357 -27.22087 0.545 20.31689 ? 1795 ILE A HD11 1 
ATOM   5525 H  HD12 A ILE A 1 336 ? -18.57250 -41.11266 -28.64815 0.455 20.78427 ? 1795 ILE A HD12 1 
ATOM   5526 H  HD12 B ILE A 1 336 ? -17.65503 -40.83708 -28.31977 0.545 20.31689 ? 1795 ILE A HD12 1 
ATOM   5527 H  HD13 A ILE A 1 336 ? -17.67625 -40.27191 -29.65482 0.455 20.78427 ? 1795 ILE A HD13 1 
ATOM   5528 H  HD13 B ILE A 1 336 ? -17.06236 -41.35249 -26.93897 0.545 20.31689 ? 1795 ILE A HD13 1 
ATOM   5529 N  N    . ASP A 1 337 ? -20.90633 -36.08123 -27.59880 1.000 16.32015 ? 1796 ASP A N    1 
ATOM   5530 C  CA   . ASP A 1 337 ? -22.06725 -35.61704 -28.36918 1.000 17.53078 ? 1796 ASP A CA   1 
ATOM   5531 C  C    . ASP A 1 337 ? -23.35633 -35.75329 -27.57578 1.000 17.36766 ? 1796 ASP A C    1 
ATOM   5532 O  O    . ASP A 1 337 ? -24.37584 -36.25427 -28.05106 1.000 16.58867 ? 1796 ASP A O    1 
ATOM   5533 C  CB   . ASP A 1 337 ? -22.14803 -36.40747 -29.68229 1.000 18.90192 ? 1796 ASP A CB   1 
ATOM   5534 C  CG   . ASP A 1 337 ? -21.07768 -36.00404 -30.68421 1.000 18.34149 ? 1796 ASP A CG   1 
ATOM   5535 O  OD1  . ASP A 1 337 ? -20.77420 -36.76713 -31.58566 1.000 20.92320 ? 1796 ASP A OD1  1 
ATOM   5536 O  OD2  . ASP A 1 337 ? -20.53115 -34.85106 -30.50920 1.000 17.49400 ? 1796 ASP A OD2  1 
ATOM   5537 H  H    . ASP A 1 337 ? -20.20259 -35.60489 -27.73093 1.000 19.58419 ? 1796 ASP A H    1 
ATOM   5538 H  HA   . ASP A 1 337 ? -21.95937 -34.67300 -28.56425 1.000 21.03694 ? 1796 ASP A HA   1 
ATOM   5539 H  HB2  . ASP A 1 337 ? -22.03655 -37.35155 -29.48942 1.000 22.68231 ? 1796 ASP A HB2  1 
ATOM   5540 H  HB3  . ASP A 1 337 ? -23.01395 -36.25234 -30.09097 1.000 22.68231 ? 1796 ASP A HB3  1 
ATOM   5541 N  N    . GLY A 1 338 ? -23.33283 -35.26690 -26.35048 1.000 19.65202 ? 1797 GLY A N    1 
ATOM   5542 C  CA   . GLY A 1 338 ? -24.53593 -35.14942 -25.56420 1.000 19.47053 ? 1797 GLY A CA   1 
ATOM   5543 C  C    . GLY A 1 338 ? -24.73451 -36.26091 -24.55230 1.000 19.32851 ? 1797 GLY A C    1 
ATOM   5544 O  O    . GLY A 1 338 ? -25.64062 -36.15768 -23.71390 1.000 23.43401 ? 1797 GLY A O    1 
ATOM   5545 H  H    . GLY A 1 338 ? -22.62167 -34.99560 -25.95017 1.000 23.58242 ? 1797 GLY A H    1 
ATOM   5546 H  HA2  . GLY A 1 338 ? -24.51287 -34.30826 -25.08168 1.000 23.36463 ? 1797 GLY A HA2  1 
ATOM   5547 H  HA3  . GLY A 1 338 ? -25.30053 -35.15023 -26.16109 1.000 23.36463 ? 1797 GLY A HA3  1 
ATOM   5548 N  N    . GLN A 1 339 ? -23.90248 -37.28078 -24.56737 1.000 17.68871 ? 1798 GLN A N    1 
ATOM   5549 C  CA   . GLN A 1 339 ? -23.99969 -38.39262 -23.63141 1.000 17.85455 ? 1798 GLN A CA   1 
ATOM   5550 C  C    . GLN A 1 339 ? -22.86213 -38.30809 -22.63513 1.000 16.54387 ? 1798 GLN A C    1 
ATOM   5551 O  O    . GLN A 1 339 ? -21.69831 -38.35668 -23.02520 1.000 17.17812 ? 1798 GLN A O    1 
ATOM   5552 C  CB   . GLN A 1 339 ? -23.90076 -39.70371 -24.42272 1.000 19.71532 ? 1798 GLN A CB   1 
ATOM   5553 C  CG   . GLN A 1 339 ? -23.84274 -41.00084 -23.57538 1.000 22.46560 ? 1798 GLN A CG   1 
ATOM   5554 C  CD   . GLN A 1 339 ? -25.13691 -41.39982 -22.97895 1.000 24.52898 ? 1798 GLN A CD   1 
ATOM   5555 O  OE1  . GLN A 1 339 ? -26.11902 -41.58917 -23.67399 1.000 25.62911 ? 1798 GLN A OE1  1 
ATOM   5556 N  NE2  . GLN A 1 339 ? -25.15319 -41.54936 -21.63132 1.000 24.89479 ? 1798 GLN A NE2  1 
ATOM   5557 H  H    . GLN A 1 339 ? -23.25239 -37.35834 -25.12502 1.000 21.22646 ? 1798 GLN A H    1 
ATOM   5558 H  HA   . GLN A 1 339 ? -24.83348 -38.35131 -23.13746 1.000 21.42546 ? 1798 GLN A HA   1 
ATOM   5559 H  HB2  . GLN A 1 339 ? -24.67890 -39.77083 -24.99795 1.000 23.65839 ? 1798 GLN A HB2  1 
ATOM   5560 H  HB3  . GLN A 1 339 ? -23.09314 -39.67458 -24.95919 1.000 23.65839 ? 1798 GLN A HB3  1 
ATOM   5561 H  HG2  . GLN A 1 339 ? -23.54512 -41.72874 -24.14325 1.000 26.95872 ? 1798 GLN A HG2  1 
ATOM   5562 H  HG3  . GLN A 1 339 ? -23.21382 -40.86838 -22.84887 1.000 26.95872 ? 1798 GLN A HG3  1 
ATOM   5563 H  HE21 . GLN A 1 339 ? -24.43708 -41.41341 -21.17491 1.000 29.87375 ? 1798 GLN A HE21 1 
ATOM   5564 H  HE22 . GLN A 1 339 ? -25.87962 -41.78016 -21.23304 1.000 29.87375 ? 1798 GLN A HE22 1 
ATOM   5565 N  N    . VAL A 1 340 ? -23.17897 -38.23110 -21.35215 1.000 15.05688 ? 1799 VAL A N    1 
ATOM   5566 C  CA   . VAL A 1 340 ? -22.20135 -38.37863 -20.28133 1.000 14.93059 ? 1799 VAL A CA   1 
ATOM   5567 C  C    . VAL A 1 340 ? -21.97603 -39.87242 -20.03457 1.000 15.86494 ? 1799 VAL A C    1 
ATOM   5568 O  O    . VAL A 1 340 ? -22.93624 -40.65136 -19.91209 1.000 19.92833 ? 1799 VAL A O    1 
ATOM   5569 C  CB   . VAL A 1 340 ? -22.63968 -37.62815 -19.03724 1.000 16.39384 ? 1799 VAL A CB   1 
ATOM   5570 C  CG1  . VAL A 1 340 ? -21.75583 -37.95163 -17.86528 1.000 17.93078 ? 1799 VAL A CG1  1 
ATOM   5571 C  CG2  . VAL A 1 340 ? -22.63847 -36.12986 -19.31976 1.000 18.38083 ? 1799 VAL A CG2  1 
ATOM   5572 H  H    . VAL A 1 340 ? -23.97704 -38.08987 -21.06452 1.000 18.06825 ? 1799 VAL A H    1 
ATOM   5573 H  HA   . VAL A 1 340 ? -21.35164 -37.99569 -20.55014 1.000 17.91670 ? 1799 VAL A HA   1 
ATOM   5574 H  HB   . VAL A 1 340 ? -23.53919 -37.90383 -18.80104 1.000 19.67261 ? 1799 VAL A HB   1 
ATOM   5575 H  HG11 . VAL A 1 340 ? -21.87555 -37.27298 -17.18263 1.000 21.51694 ? 1799 VAL A HG11 1 
ATOM   5576 H  HG12 . VAL A 1 340 ? -22.00289 -38.82137 -17.51397 1.000 21.51694 ? 1799 VAL A HG12 1 
ATOM   5577 H  HG13 . VAL A 1 340 ? -20.83194 -37.96443 -18.16054 1.000 21.51694 ? 1799 VAL A HG13 1 
ATOM   5578 H  HG21 . VAL A 1 340 ? -22.91907 -35.65752 -18.52034 1.000 22.05700 ? 1799 VAL A HG21 1 
ATOM   5579 H  HG22 . VAL A 1 340 ? -21.74167 -35.85605 -19.56812 1.000 22.05700 ? 1799 VAL A HG22 1 
ATOM   5580 H  HG23 . VAL A 1 340 ? -23.25391 -35.94500 -20.04636 1.000 22.05700 ? 1799 VAL A HG23 1 
ATOM   5581 N  N    . LEU A 1 341 ? -20.71837 -40.29362 -20.00986 1.000 16.19651 ? 1800 LEU A N    1 
ATOM   5582 C  CA   . LEU A 1 341 ? -20.34489 -41.71029 -19.97764 1.000 17.38610 ? 1800 LEU A CA   1 
ATOM   5583 C  C    . LEU A 1 341 ? -19.51766 -42.07828 -18.74785 1.000 17.91773 ? 1800 LEU A C    1 
ATOM   5584 O  O    . LEU A 1 341 ? -19.02801 -43.23044 -18.65911 1.000 21.61280 ? 1800 LEU A O    1 
ATOM   5585 C  CB   . LEU A 1 341 ? -19.60973 -42.10014 -21.26475 1.000 18.67834 ? 1800 LEU A CB   1 
ATOM   5586 C  CG   . LEU A 1 341 ? -20.49039 -42.02702 -22.50040 1.000 20.71545 ? 1800 LEU A CG   1 
ATOM   5587 C  CD1  . LEU A 1 341 ? -19.67990 -41.91102 -23.76704 1.000 23.60243 ? 1800 LEU A CD1  1 
ATOM   5588 C  CD2  . LEU A 1 341 ? -21.41490 -43.26224 -22.55352 1.000 23.54988 ? 1800 LEU A CD2  1 
ATOM   5589 H  H    . LEU A 1 341 ? -20.03952 -39.76564 -20.01107 1.000 19.43581 ? 1800 LEU A H    1 
ATOM   5590 H  HA   . LEU A 1 341 ? -21.15661 -42.23985 -19.93790 1.000 20.86332 ? 1800 LEU A HA   1 
ATOM   5591 H  HB2  . LEU A 1 341 ? -18.86178 -41.49616 -21.39392 1.000 22.41401 ? 1800 LEU A HB2  1 
ATOM   5592 H  HB3  . LEU A 1 341 ? -19.28915 -43.01161 -21.17901 1.000 22.41401 ? 1800 LEU A HB3  1 
ATOM   5593 H  HG   . LEU A 1 341 ? -21.03448 -41.22584 -22.44585 1.000 24.85854 ? 1800 LEU A HG   1 
ATOM   5594 H  HD11 . LEU A 1 341 ? -20.26699 -42.03136 -24.52976 1.000 28.32291 ? 1800 LEU A HD11 1 
ATOM   5595 H  HD12 . LEU A 1 341 ? -19.27012 -41.03246 -23.80040 1.000 28.32291 ? 1800 LEU A HD12 1 
ATOM   5596 H  HD13 . LEU A 1 341 ? -18.99346 -42.59638 -23.76660 1.000 28.32291 ? 1800 LEU A HD13 1 
ATOM   5597 H  HD21 . LEU A 1 341 ? -21.94136 -43.22789 -23.36750 1.000 28.25986 ? 1800 LEU A HD21 1 
ATOM   5598 H  HD22 . LEU A 1 341 ? -20.87031 -44.06489 -22.54545 1.000 28.25986 ? 1800 LEU A HD22 1 
ATOM   5599 H  HD23 . LEU A 1 341 ? -22.00040 -43.25197 -21.78023 1.000 28.25986 ? 1800 LEU A HD23 1 
ATOM   5600 N  N    . VAL A 1 342 ? -19.32515 -41.15829 -17.79600 1.000 14.61215 ? 1801 VAL A N    1 
ATOM   5601 C  CA   . VAL A 1 342 ? -18.79597 -41.51011 -16.48747 1.000 14.95156 ? 1801 VAL A CA   1 
ATOM   5602 C  C    . VAL A 1 342 ? -19.87612 -41.33210 -15.43064 1.000 15.90424 ? 1801 VAL A C    1 
ATOM   5603 O  O    . VAL A 1 342 ? -20.69967 -40.41021 -15.51950 1.000 15.38582 ? 1801 VAL A O    1 
ATOM   5604 C  CB   . VAL A 1 342 ? -17.51045 -40.72492 -16.14420 1.000 14.75420 ? 1801 VAL A CB   1 
ATOM   5605 C  CG1  . VAL A 1 342 ? -16.31567 -41.21618 -16.96116 1.000 15.49633 ? 1801 VAL A CG1  1 
ATOM   5606 C  CG2  . VAL A 1 342 ? -17.74231 -39.23693 -16.31918 1.000 15.20419 ? 1801 VAL A CG2  1 
ATOM   5607 H  H    . VAL A 1 342 ? -19.49635 -40.32085 -17.89077 1.000 17.53458 ? 1801 VAL A H    1 
ATOM   5608 H  HA   . VAL A 1 342 ? -18.56015 -42.45088 -16.50334 1.000 17.94187 ? 1801 VAL A HA   1 
ATOM   5609 H  HB   . VAL A 1 342 ? -17.28777 -40.88300 -15.21344 1.000 17.70504 ? 1801 VAL A HB   1 
ATOM   5610 H  HG11 . VAL A 1 342 ? -15.54948 -40.65280 -16.77025 1.000 18.59559 ? 1801 VAL A HG11 1 
ATOM   5611 H  HG12 . VAL A 1 342 ? -16.12085 -42.13402 -16.71516 1.000 18.59559 ? 1801 VAL A HG12 1 
ATOM   5612 H  HG13 . VAL A 1 342 ? -16.53612 -41.16622 -17.90446 1.000 18.59559 ? 1801 VAL A HG13 1 
ATOM   5613 H  HG21 . VAL A 1 342 ? -16.95458 -38.75712 -16.01893 1.000 18.24503 ? 1801 VAL A HG21 1 
ATOM   5614 H  HG22 . VAL A 1 342 ? -17.90546 -39.05088 -17.25708 1.000 18.24503 ? 1801 VAL A HG22 1 
ATOM   5615 H  HG23 . VAL A 1 342 ? -18.51179 -38.97294 -15.79086 1.000 18.24503 ? 1801 VAL A HG23 1 
ATOM   5616 N  N    . PRO A 1 343 ? -19.92270 -42.21779 -14.45340 1.000 15.98331 ? 1802 PRO A N    1 
ATOM   5617 C  CA   . PRO A 1 343 ? -21.02160 -42.19930 -13.48064 1.000 16.23854 ? 1802 PRO A CA   1 
ATOM   5618 C  C    . PRO A 1 343 ? -20.77209 -41.18752 -12.38085 1.000 14.94101 ? 1802 PRO A C    1 
ATOM   5619 O  O    . PRO A 1 343 ? -19.62558 -40.77550 -12.13076 1.000 14.56467 ? 1802 PRO A O    1 
ATOM   5620 C  CB   . PRO A 1 343 ? -20.98662 -43.61892 -12.91481 1.000 17.99661 ? 1802 PRO A CB   1 
ATOM   5621 C  CG   . PRO A 1 343 ? -19.50731 -43.97395 -13.01270 1.000 17.52026 ? 1802 PRO A CG   1 
ATOM   5622 C  CD   . PRO A 1 343 ? -19.09245 -43.43110 -14.31942 1.000 16.13328 ? 1802 PRO A CD   1 
ATOM   5623 H  HA   . PRO A 1 343 ? -21.86849 -42.01402 -13.91578 1.000 19.48625 ? 1802 PRO A HA   1 
ATOM   5624 H  HB2  . PRO A 1 343 ? -21.29507 -43.62674 -11.99519 1.000 21.59594 ? 1802 PRO A HB2  1 
ATOM   5625 H  HB3  . PRO A 1 343 ? -21.53235 -44.21357 -13.45284 1.000 21.59594 ? 1802 PRO A HB3  1 
ATOM   5626 H  HG2  . PRO A 1 343 ? -19.01498 -43.55693 -12.28840 1.000 21.02432 ? 1802 PRO A HG2  1 
ATOM   5627 H  HG3  . PRO A 1 343 ? -19.39192 -44.93655 -12.98121 1.000 21.02432 ? 1802 PRO A HG3  1 
ATOM   5628 H  HD2  . PRO A 1 343 ? -18.14879 -43.20661 -14.31744 1.000 19.35993 ? 1802 PRO A HD2  1 
ATOM   5629 H  HD3  . PRO A 1 343 ? -19.28211 -44.06106 -15.03221 1.000 19.35993 ? 1802 PRO A HD3  1 
ATOM   5630 N  N    . PRO A 1 344 ? -21.79733 -40.87258 -11.60560 1.000 13.97781 ? 1803 PRO A N    1 
ATOM   5631 C  CA   . PRO A 1 344 ? -21.57308 -40.14669 -10.36010 1.000 13.31462 ? 1803 PRO A CA   1 
ATOM   5632 C  C    . PRO A 1 344 ? -20.58743 -40.87249 -9.48591  1.000 14.33568 ? 1803 PRO A C    1 
ATOM   5633 O  O    . PRO A 1 344 ? -20.63985 -42.10740 -9.37684  1.000 15.11210 ? 1803 PRO A O    1 
ATOM   5634 C  CB   . PRO A 1 344 ? -22.96799 -40.08952 -9.71273  1.000 15.25418 ? 1803 PRO A CB   1 
ATOM   5635 C  CG   . PRO A 1 344 ? -23.91138 -40.33109 -10.82206 1.000 15.82002 ? 1803 PRO A CG   1 
ATOM   5636 C  CD   . PRO A 1 344 ? -23.21220 -41.32325 -11.70840 1.000 15.60683 ? 1803 PRO A CD   1 
ATOM   5637 H  HA   . PRO A 1 344 ? -21.26385 -39.24491 -10.53917 1.000 15.97755 ? 1803 PRO A HA   1 
ATOM   5638 H  HB2  . PRO A 1 344 ? -23.04593 -40.77819 -9.03408  1.000 18.30502 ? 1803 PRO A HB2  1 
ATOM   5639 H  HB3  . PRO A 1 344 ? -23.11322 -39.21588 -9.31706  1.000 18.30502 ? 1803 PRO A HB3  1 
ATOM   5640 H  HG2  . PRO A 1 344 ? -24.74144 -40.69659 -10.47808 1.000 18.98403 ? 1803 PRO A HG2  1 
ATOM   5641 H  HG3  . PRO A 1 344 ? -24.08490 -39.50293 -11.29634 1.000 18.98403 ? 1803 PRO A HG3  1 
ATOM   5642 H  HD2  . PRO A 1 344 ? -23.31803 -42.22804 -11.37516 1.000 18.72820 ? 1803 PRO A HD2  1 
ATOM   5643 H  HD3  . PRO A 1 344 ? -23.53375 -41.26638 -12.62179 1.000 18.72820 ? 1803 PRO A HD3  1 
ATOM   5644 N  N    . GLY A 1 345 ? -19.60080 -40.13200 -8.95299  1.000 13.82506 ? 1804 GLY A N    1 
ATOM   5645 C  CA   . GLY A 1 345 ? -18.55670 -40.71823 -8.16639  1.000 14.10926 ? 1804 GLY A CA   1 
ATOM   5646 C  C    . GLY A 1 345 ? -17.25598 -40.95553 -8.90389  1.000 12.90933 ? 1804 GLY A C    1 
ATOM   5647 O  O    . GLY A 1 345 ? -16.23871 -41.27092 -8.25148  1.000 14.12246 ? 1804 GLY A O    1 
ATOM   5648 H  H    . GLY A 1 345 ? -19.53230 -39.27981 -9.04612  1.000 16.59008 ? 1804 GLY A H    1 
ATOM   5649 H  HA2  . GLY A 1 345 ? -18.36800 -40.13313 -7.41609  1.000 16.93112 ? 1804 GLY A HA2  1 
ATOM   5650 H  HA3  . GLY A 1 345 ? -18.86538 -41.57396 -7.82971  1.000 16.93112 ? 1804 GLY A HA3  1 
ATOM   5651 N  N    . TYR A 1 346 ? -17.23719 -40.78688 -10.21553 1.000 13.44872 ? 1805 TYR A N    1 
ATOM   5652 C  CA   . TYR A 1 346 ? -15.96756 -40.87400 -10.93688 1.000 13.14345 ? 1805 TYR A CA   1 
ATOM   5653 C  C    . TYR A 1 346 ? -15.01397 -39.74012 -10.56484 1.000 12.98549 ? 1805 TYR A C    1 
ATOM   5654 O  O    . TYR A 1 346 ? -13.78469 -39.90654 -10.54280 1.000 13.47240 ? 1805 TYR A O    1 
ATOM   5655 C  CB   . TYR A 1 346 ? -16.21192 -40.84297 -12.44284 1.000 13.68296 ? 1805 TYR A CB   1 
ATOM   5656 C  CG   . TYR A 1 346 ? -14.96695 -41.04315 -13.26150 1.000 13.71982 ? 1805 TYR A CG   1 
ATOM   5657 C  CD1  . TYR A 1 346 ? -14.37204 -42.28919 -13.37299 1.000 14.46990 ? 1805 TYR A CD1  1 
ATOM   5658 C  CD2  . TYR A 1 346 ? -14.39164 -39.98785 -13.92371 1.000 13.19085 ? 1805 TYR A CD2  1 
ATOM   5659 C  CE1  . TYR A 1 346 ? -13.22562 -42.44479 -14.10041 1.000 15.08305 ? 1805 TYR A CE1  1 
ATOM   5660 C  CE2  . TYR A 1 346 ? -13.25332 -40.14197 -14.68667 1.000 13.59086 ? 1805 TYR A CE2  1 
ATOM   5661 C  CZ   . TYR A 1 346 ? -12.65611 -41.37238 -14.76106 1.000 13.51985 ? 1805 TYR A CZ   1 
ATOM   5662 O  OH   . TYR A 1 346 ? -11.48099 -41.58383 -15.47889 1.000 14.48306 ? 1805 TYR A OH   1 
ATOM   5663 H  H    . TYR A 1 346 ? -17.92516 -40.62461 -10.70540 1.000 16.13847 ? 1805 TYR A H    1 
ATOM   5664 H  HA   . TYR A 1 346 ? -15.55103 -41.71789 -10.70183 1.000 15.77214 ? 1805 TYR A HA   1 
ATOM   5665 H  HB2  . TYR A 1 346 ? -16.83453 -41.55042 -12.67257 1.000 16.41955 ? 1805 TYR A HB2  1 
ATOM   5666 H  HB3  . TYR A 1 346 ? -16.58725 -39.98064 -12.68035 1.000 16.41955 ? 1805 TYR A HB3  1 
ATOM   5667 H  HD1  . TYR A 1 346 ? -14.75492 -43.02390 -12.95049 1.000 17.36388 ? 1805 TYR A HD1  1 
ATOM   5668 H  HD2  . TYR A 1 346 ? -14.78011 -39.14558 -13.85609 1.000 15.82902 ? 1805 TYR A HD2  1 
ATOM   5669 H  HE1  . TYR A 1 346 ? -12.82390 -43.28199 -14.15157 1.000 18.09966 ? 1805 TYR A HE1  1 
ATOM   5670 H  HE2  . TYR A 1 346 ? -12.89457 -39.41745 -15.14629 1.000 16.30904 ? 1805 TYR A HE2  1 
ATOM   5671 H  HH   . TYR A 1 346 ? -11.22675 -40.86528 -15.83194 1.000 17.37967 ? 1805 TYR A HH   1 
ATOM   5672 N  N    . GLY A 1 347 ? -15.56928 -38.58237 -10.26320 1.000 12.41445 ? 1806 GLY A N    1 
ATOM   5673 C  CA   . GLY A 1 347 ? -14.74260 -37.42004 -9.93476  1.000 12.05384 ? 1806 GLY A CA   1 
ATOM   5674 C  C    . GLY A 1 347 ? -14.12439 -37.50190 -8.55809  1.000 12.30382 ? 1806 GLY A C    1 
ATOM   5675 O  O    . GLY A 1 347 ? -14.61609 -38.18385 -7.64519  1.000 12.60386 ? 1806 GLY A O    1 
ATOM   5676 H  H    . GLY A 1 347 ? -16.41626 -38.43519 -10.23920 1.000 14.89734 ? 1806 GLY A H    1 
ATOM   5677 H  HA2  . GLY A 1 347 ? -14.02598 -37.34532 -10.58420 1.000 14.46460 ? 1806 GLY A HA2  1 
ATOM   5678 H  HA3  . GLY A 1 347 ? -15.28897 -36.61951 -9.97388  1.000 14.46460 ? 1806 GLY A HA3  1 
ATOM   5679 N  N    . GLN A 1 348 ? -12.97047 -36.79997 -8.44182  1.000 11.50385 ? 1807 GLN A N    1 
ATOM   5680 C  CA   . GLN A 1 348 ? -12.17609 -36.83591 -7.23769  1.000 11.83538 ? 1807 GLN A CA   1 
ATOM   5681 C  C    . GLN A 1 348 ? -11.83352 -35.43824 -6.73715  1.000 11.44850 ? 1807 GLN A C    1 
ATOM   5682 O  O    . GLN A 1 348 ? -11.80446 -34.46671 -7.49589  1.000 11.71430 ? 1807 GLN A O    1 
ATOM   5683 C  CB   . GLN A 1 348 ? -10.84538 -37.56973 -7.45483  1.000 12.60126 ? 1807 GLN A CB   1 
ATOM   5684 C  CG   . GLN A 1 348 ? -11.05663 -39.03160 -7.91913  1.000 12.72237 ? 1807 GLN A CG   1 
ATOM   5685 C  CD   . GLN A 1 348 ? -9.74204  -39.74541 -8.21594  1.000 15.12001 ? 1807 GLN A CD   1 
ATOM   5686 O  OE1  . GLN A 1 348 ? -8.66733  -39.28922 -7.82245  1.000 17.02017 ? 1807 GLN A OE1  1 
ATOM   5687 N  NE2  . GLN A 1 348 ? -9.81090  -40.87582 -8.90220  1.000 16.05691 ? 1807 GLN A NE2  1 
ATOM   5688 H  H    . GLN A 1 348 ? -12.64461 -36.30043 -9.06140  1.000 13.80462 ? 1807 GLN A H    1 
ATOM   5689 H  HA   . GLN A 1 348 ? -12.71460 -37.28345 -6.56642  1.000 14.20245 ? 1807 GLN A HA   1 
ATOM   5690 H  HB2  . GLN A 1 348 ? -10.33359 -37.10605 -8.13598  1.000 15.12151 ? 1807 GLN A HB2  1 
ATOM   5691 H  HB3  . GLN A 1 348 ? -10.35039 -37.58487 -6.62077  1.000 15.12151 ? 1807 GLN A HB3  1 
ATOM   5692 H  HG2  . GLN A 1 348 ? -11.51495 -39.52332 -7.21981  1.000 15.26685 ? 1807 GLN A HG2  1 
ATOM   5693 H  HG3  . GLN A 1 348 ? -11.58960 -39.03301 -8.72959  1.000 15.26685 ? 1807 GLN A HG3  1 
ATOM   5694 H  HE21 . GLN A 1 348 ? -10.57428 -41.17668 -9.15975  1.000 19.26829 ? 1807 GLN A HE21 1 
ATOM   5695 H  HE22 . GLN A 1 348 ? -9.09224  -41.30910 -9.09033  1.000 19.26829 ? 1807 GLN A HE22 1 
ATOM   5696 N  N    . ASP A 1 349 ? -11.54317 -35.36690 -5.44235  1.000 12.16698 ? 1808 ASP A N    1 
ATOM   5697 C  CA   . ASP A 1 349 ? -11.10859 -34.14256 -4.76138  1.000 11.81697 ? 1808 ASP A CA   1 
ATOM   5698 C  C    . ASP A 1 349 ? -9.63985  -33.92078 -5.04925  1.000 11.15903 ? 1808 ASP A C    1 
ATOM   5699 O  O    . ASP A 1 349 ? -8.78272  -34.64918 -4.53265  1.000 11.83797 ? 1808 ASP A O    1 
ATOM   5700 C  CB   . ASP A 1 349 ? -11.36299 -34.31099 -3.27870  1.000 12.34071 ? 1808 ASP A CB   1 
ATOM   5701 C  CG   . ASP A 1 349 ? -11.02876 -33.07827 -2.45843  1.000 12.14078 ? 1808 ASP A CG   1 
ATOM   5702 O  OD1  . ASP A 1 349 ? -10.45008 -32.10307 -2.99707  1.000 12.20124 ? 1808 ASP A OD1  1 
ATOM   5703 O  OD2  . ASP A 1 349 ? -11.36988 -33.12014 -1.25717  1.000 15.35670 ? 1808 ASP A OD2  1 
ATOM   5704 H  H    . ASP A 1 349 ? -11.59079 -36.04066 -4.91001  1.000 14.60037 ? 1808 ASP A H    1 
ATOM   5705 H  HA   . ASP A 1 349 ? -11.59374 -33.36890 -5.08845  1.000 14.18037 ? 1808 ASP A HA   1 
ATOM   5706 H  HB2  . ASP A 1 349 ? -12.30257 -34.51056 -3.14356  1.000 14.80885 ? 1808 ASP A HB2  1 
ATOM   5707 H  HB3  . ASP A 1 349 ? -10.81774 -35.04246 -2.94922  1.000 14.80885 ? 1808 ASP A HB3  1 
ATOM   5708 N  N    . VAL A 1 350 ? -9.34882  -32.93661 -5.90362  1.000 10.77218 ? 1809 VAL A N    1 
ATOM   5709 C  CA   . VAL A 1 350 ? -7.96855  -32.71918 -6.33178  1.000 11.19053 ? 1809 VAL A CA   1 
ATOM   5710 C  C    . VAL A 1 350 ? -7.05752  -32.30000 -5.19498  1.000 10.60112 ? 1809 VAL A C    1 
ATOM   5711 O  O    . VAL A 1 350 ? -5.83526  -32.49075 -5.31268  1.000 12.12748 ? 1809 VAL A O    1 
ATOM   5712 C  CB   . VAL A 1 350 ? -7.87014  -31.73347 -7.50641  1.000 11.88275 ? 1809 VAL A CB   1 
ATOM   5713 C  CG1  . VAL A 1 350 ? -8.71496  -32.21315 -8.68880  1.000 12.45121 ? 1809 VAL A CG1  1 
ATOM   5714 C  CG2  . VAL A 1 350 ? -8.25339  -30.30283 -7.07375  1.000 11.89067 ? 1809 VAL A CG2  1 
ATOM   5715 H  H    . VAL A 1 350 ? -9.92170  -32.39217 -6.24274  1.000 12.92662 ? 1809 VAL A H    1 
ATOM   5716 H  HA   . VAL A 1 350 ? -7.65184  -33.57685 -6.65583  1.000 13.42864 ? 1809 VAL A HA   1 
ATOM   5717 H  HB   . VAL A 1 350 ? -6.94707  -31.69916 -7.80249  1.000 14.25930 ? 1809 VAL A HB   1 
ATOM   5718 H  HG11 . VAL A 1 350 ? -8.59861  -31.59841 -9.43005  1.000 14.94145 ? 1809 VAL A HG11 1 
ATOM   5719 H  HG12 . VAL A 1 350 ? -8.42208  -33.10125 -8.94650  1.000 14.94145 ? 1809 VAL A HG12 1 
ATOM   5720 H  HG13 . VAL A 1 350 ? -9.64721  -32.23677 -8.42186  1.000 14.94145 ? 1809 VAL A HG13 1 
ATOM   5721 H  HG21 . VAL A 1 350 ? -8.30654  -29.73843 -7.86085  1.000 14.26880 ? 1809 VAL A HG21 1 
ATOM   5722 H  HG22 . VAL A 1 350 ? -9.11355  -30.32803 -6.62610  1.000 14.26880 ? 1809 VAL A HG22 1 
ATOM   5723 H  HG23 . VAL A 1 350 ? -7.57539  -29.96360 -6.46865  1.000 14.26880 ? 1809 VAL A HG23 1 
ATOM   5724 N  N    . ARG A 1 351 ? -7.57425  -31.77418 -4.08855  1.000 11.08794 ? 1810 ARG A N    1 
ATOM   5725 C  CA   . ARG A 1 351 ? -6.75477  -31.37268 -2.96787  1.000 11.86959 ? 1810 ARG A CA   1 
ATOM   5726 C  C    . ARG A 1 351 ? -6.19749  -32.55700 -2.20414  1.000 13.13292 ? 1810 ARG A C    1 
ATOM   5727 O  O    . ARG A 1 351 ? -5.33061  -32.37509 -1.38573  1.000 15.53312 ? 1810 ARG A O    1 
ATOM   5728 C  CB   . ARG A 1 351 ? -7.52692  -30.43324 -2.03936  1.000 11.95907 ? 1810 ARG A CB   1 
ATOM   5729 C  CG   . ARG A 1 351 ? -7.59963  -28.98505 -2.51715  1.000 11.63802 ? 1810 ARG A CG   1 
ATOM   5730 C  CD   . ARG A 1 351 ? -6.31097  -28.22798 -2.24461  1.000 12.50382 ? 1810 ARG A CD   1 
ATOM   5731 N  NE   . ARG A 1 351 ? -6.45590  -26.80551 -2.58265  1.000 11.51957 ? 1810 ARG A NE   1 
ATOM   5732 C  CZ   . ARG A 1 351 ? -5.93188  -26.19304 -3.63860  1.000 10.09315 ? 1810 ARG A CZ   1 
ATOM   5733 N  NH1  . ARG A 1 351 ? -5.06931  -26.77123 -4.44008  1.000 11.14578 ? 1810 ARG A NH1  1 
ATOM   5734 N  NH2  . ARG A 1 351 ? -6.24732  -24.91545 -3.84785  1.000 10.64838 ? 1810 ARG A NH2  1 
ATOM   5735 H  H    . ARG A 1 351 ? -8.41467  -31.63933 -3.96565  1.000 13.30553 ? 1810 ARG A H    1 
ATOM   5736 H  HA   . ARG A 1 351 ? -5.99938  -30.86347 -3.30102  1.000 14.24351 ? 1810 ARG A HA   1 
ATOM   5737 H  HB2  . ARG A 1 351 ? -8.43649  -30.76002 -1.95686  1.000 14.35088 ? 1810 ARG A HB2  1 
ATOM   5738 H  HB3  . ARG A 1 351 ? -7.09431  -30.43341 -1.17117  1.000 14.35088 ? 1810 ARG A HB3  1 
ATOM   5739 H  HG2  . ARG A 1 351 ? -7.76125  -28.97237 -3.47351  1.000 13.96562 ? 1810 ARG A HG2  1 
ATOM   5740 H  HG3  . ARG A 1 351 ? -8.32059  -28.53173 -2.05281  1.000 13.96562 ? 1810 ARG A HG3  1 
ATOM   5741 H  HD2  . ARG A 1 351 ? -6.08726  -28.29901 -1.30343  1.000 15.00458 ? 1810 ARG A HD2  1 
ATOM   5742 H  HD3  . ARG A 1 351 ? -5.59662  -28.60099 -2.78448  1.000 15.00458 ? 1810 ARG A HD3  1 
ATOM   5743 H  HE   . ARG A 1 351 ? -6.92441  -26.32370 -2.04604  1.000 13.82349 ? 1810 ARG A HE   1 
ATOM   5744 H  HH11 . ARG A 1 351 ? -4.82038  -27.58096 -4.29181  1.000 13.37494 ? 1810 ARG A HH11 1 
ATOM   5745 H  HH12 . ARG A 1 351 ? -4.75273  -26.34058 -5.11381  1.000 13.37494 ? 1810 ARG A HH12 1 
ATOM   5746 H  HH21 . ARG A 1 351 ? -6.77745  -24.50913 -3.30611  1.000 12.77805 ? 1810 ARG A HH21 1 
ATOM   5747 H  HH22 . ARG A 1 351 ? -5.92078  -24.49719 -4.52463  1.000 12.77805 ? 1810 ARG A HH22 1 
ATOM   5748 N  N    . LYS A 1 352 ? -6.73318  -33.75474 -2.42904  1.000 13.39881 ? 1811 LYS A N    1 
ATOM   5749 C  CA   . LYS A 1 352 ? -6.21175  -34.97345 -1.81818  1.000 14.05417 ? 1811 LYS A CA   1 
ATOM   5750 C  C    . LYS A 1 352 ? -5.09755  -35.59191 -2.63850  1.000 14.12788 ? 1811 LYS A C    1 
ATOM   5751 O  O    . LYS A 1 352 ? -4.42279  -36.50732 -2.14268  1.000 17.48067 ? 1811 LYS A O    1 
ATOM   5752 C  CB   . LYS A 1 352 ? -7.38165  -35.96557 -1.59143  1.000 16.98580 ? 1811 LYS A CB   1 
ATOM   5753 H  H    . LYS A 1 352 ? -7.41113  -33.89001 -2.94059  1.000 16.07858 ? 1811 LYS A H    1 
ATOM   5754 H  HA   . LYS A 1 352 ? -5.83372  -34.78946 -0.94403  1.000 16.86500 ? 1811 LYS A HA   1 
ATOM   5755 N  N    . TRP A 1 353 ? -4.93709  -35.22419 -3.89055  1.000 14.05147 ? 1812 TRP A N    1 
ATOM   5756 C  CA   . TRP A 1 353 ? -3.85364  -35.72974 -4.69683  1.000 14.48314 ? 1812 TRP A CA   1 
ATOM   5757 C  C    . TRP A 1 353 ? -2.52351  -35.15491 -4.17727  1.000 15.91749 ? 1812 TRP A C    1 
ATOM   5758 O  O    . TRP A 1 353 ? -2.45581  -34.00331 -3.78493  1.000 16.12272 ? 1812 TRP A O    1 
ATOM   5759 C  CB   . TRP A 1 353 ? -4.02688  -35.29276 -6.14713  1.000 13.37504 ? 1812 TRP A CB   1 
ATOM   5760 C  CG   . TRP A 1 353 ? -5.26977  -35.78200 -6.83466  1.000 12.97503 ? 1812 TRP A CG   1 
ATOM   5761 C  CD1  . TRP A 1 353 ? -6.15959  -36.73571 -6.35710  1.000 13.69607 ? 1812 TRP A CD1  1 
ATOM   5762 C  CD2  . TRP A 1 353 ? -5.70862  -35.45042 -8.13914  1.000 12.99348 ? 1812 TRP A CD2  1 
ATOM   5763 N  NE1  . TRP A 1 353 ? -7.13745  -36.93112 -7.28377  1.000 13.25924 ? 1812 TRP A NE1  1 
ATOM   5764 C  CE2  . TRP A 1 353 ? -6.90801  -36.16133 -8.38532  1.000 12.65392 ? 1812 TRP A CE2  1 
ATOM   5765 C  CE3  . TRP A 1 353 ? -5.22291  -34.59353 -9.13356  1.000 13.23034 ? 1812 TRP A CE3  1 
ATOM   5766 C  CZ2  . TRP A 1 353 ? -7.57924  -36.04802 -9.56172  1.000 12.74605 ? 1812 TRP A CZ2  1 
ATOM   5767 C  CZ3  . TRP A 1 353 ? -5.89709  -34.47595 -10.30266 1.000 14.65669 ? 1812 TRP A CZ3  1 
ATOM   5768 C  CH2  . TRP A 1 353 ? -7.08296  -35.20095 -10.51965 1.000 14.19882 ? 1812 TRP A CH2  1 
ATOM   5769 H  H    . TRP A 1 353 ? -5.45102  -34.67302 -4.30489  1.000 16.86176 ? 1812 TRP A H    1 
ATOM   5770 H  HA   . TRP A 1 353 ? -3.83861  -36.69864 -4.65305  1.000 17.37977 ? 1812 TRP A HA   1 
ATOM   5771 H  HB2  . TRP A 1 353 ? -4.04792  -34.32330 -6.17187  1.000 16.05005 ? 1812 TRP A HB2  1 
ATOM   5772 H  HB3  . TRP A 1 353 ? -3.26921  -35.62125 -6.65597  1.000 16.05005 ? 1812 TRP A HB3  1 
ATOM   5773 H  HD1  . TRP A 1 353 ? -6.09740  -37.17027 -5.53723  1.000 16.43529 ? 1812 TRP A HD1  1 
ATOM   5774 H  HE1  . TRP A 1 353 ? -7.80523  -37.46450 -7.18792  1.000 15.91108 ? 1812 TRP A HE1  1 
ATOM   5775 H  HE3  . TRP A 1 353 ? -4.44234  -34.10799 -8.99261  1.000 15.87641 ? 1812 TRP A HE3  1 
ATOM   5776 H  HZ2  . TRP A 1 353 ? -8.35751  -36.53389 -9.71377  1.000 15.29526 ? 1812 TRP A HZ2  1 
ATOM   5777 H  HZ3  . TRP A 1 353 ? -5.57339  -33.91146 -10.96708 1.000 17.58802 ? 1812 TRP A HZ3  1 
ATOM   5778 H  HH2  . TRP A 1 353 ? -7.53756  -35.10440 -11.32520 1.000 17.03858 ? 1812 TRP A HH2  1 
ATOM   5779 N  N    . PRO A 1 354 ? -1.44783  -35.93806 -4.16188  1.000 18.99418 ? 1813 PRO A N    1 
ATOM   5780 C  CA   . PRO A 1 354 ? -0.16511  -35.36995 -3.67826  1.000 20.06007 ? 1813 PRO A CA   1 
ATOM   5781 C  C    . PRO A 1 354 ? 0.25560   -34.09301 -4.39967  1.000 19.09944 ? 1813 PRO A C    1 
ATOM   5782 O  O    . PRO A 1 354 ? 0.75572   -33.14186 -3.78022  1.000 21.01270 ? 1813 PRO A O    1 
ATOM   5783 C  CB   . PRO A 1 354 ? 0.82770   -36.53563 -3.85459  1.000 21.80760 ? 1813 PRO A CB   1 
ATOM   5784 C  CG   . PRO A 1 354 ? -0.01719  -37.74165 -3.84257  1.000 23.14453 ? 1813 PRO A CG   1 
ATOM   5785 C  CD   . PRO A 1 354 ? -1.34890  -37.38417 -4.44018  1.000 21.35755 ? 1813 PRO A CD   1 
ATOM   5786 H  HA   . PRO A 1 354 ? -0.22787  -35.17178 -2.73079  1.000 24.07208 ? 1813 PRO A HA   1 
ATOM   5787 H  HB2  . PRO A 1 354 ? 1.29804   -36.44709 -4.69830  1.000 26.16912 ? 1813 PRO A HB2  1 
ATOM   5788 H  HB3  . PRO A 1 354 ? 1.46192   -36.54616 -3.12073  1.000 26.16912 ? 1813 PRO A HB3  1 
ATOM   5789 H  HG2  . PRO A 1 354 ? 0.41103   -38.43516 -4.36848  1.000 27.77344 ? 1813 PRO A HG2  1 
ATOM   5790 H  HG3  . PRO A 1 354 ? -0.13017  -38.04164 -2.92707  1.000 27.77344 ? 1813 PRO A HG3  1 
ATOM   5791 H  HD2  . PRO A 1 354 ? -1.35950  -37.55640 -5.39471  1.000 25.62906 ? 1813 PRO A HD2  1 
ATOM   5792 H  HD3  . PRO A 1 354 ? -2.06688  -37.87184 -4.00708  1.000 25.62906 ? 1813 PRO A HD3  1 
ATOM   5793 N  N    . GLN A 1 355 ? -0.00902  -34.02507 -5.67661  1.000 17.57038 ? 1814 GLN A N    1 
ATOM   5794 C  CA   . GLN A 1 355 ? 0.32254   -32.88725 -6.49141  1.000 18.01769 ? 1814 GLN A CA   1 
ATOM   5795 C  C    . GLN A 1 355 ? -0.68663  -31.73865 -6.34409  1.000 17.39135 ? 1814 GLN A C    1 
ATOM   5796 O  O    . GLN A 1 355 ? -0.44174  -30.64894 -6.84422  1.000 19.29936 ? 1814 GLN A O    1 
ATOM   5797 C  CB   . GLN A 1 355 ? 0.45509   -33.38430 -7.94099  1.000 20.96269 ? 1814 GLN A CB   1 
ATOM   5798 C  CG   . GLN A 1 355 ? -0.78462  -34.02143 -8.57485  1.000 21.21276 ? 1814 GLN A CG   1 
ATOM   5799 C  CD   . GLN A 1 355 ? -1.01650  -35.49723 -8.28276  1.000 19.16276 ? 1814 GLN A CD   1 
ATOM   5800 O  OE1  . GLN A 1 355 ? -0.61721  -36.04614 -7.26729  1.000 20.67328 ? 1814 GLN A OE1  1 
ATOM   5801 N  NE2  . GLN A 1 355 ? -1.66620  -36.13871 -9.21682  1.000 22.23390 ? 1814 GLN A NE2  1 
ATOM   5802 H  H    . GLN A 1 355 ? -0.39807  -34.65275 -6.11736  1.000 21.08446 ? 1814 GLN A H    1 
ATOM   5803 H  HA   . GLN A 1 355 ? 1.17500   -32.49949 -6.23873  1.000 21.62122 ? 1814 GLN A HA   1 
ATOM   5804 H  HB2  . GLN A 1 355 ? 0.69756   -32.62651 -8.49585  1.000 25.15522 ? 1814 GLN A HB2  1 
ATOM   5805 H  HB3  . GLN A 1 355 ? 1.15860   -34.05167 -7.96502  1.000 25.15522 ? 1814 GLN A HB3  1 
ATOM   5806 H  HG2  . GLN A 1 355 ? -1.56579  -33.54308 -8.25571  1.000 25.45531 ? 1814 GLN A HG2  1 
ATOM   5807 H  HG3  . GLN A 1 355 ? -0.71080  -33.93117 -9.53782  1.000 25.45531 ? 1814 GLN A HG3  1 
ATOM   5808 H  HE21 . GLN A 1 355 ? -1.92424  -35.72306 -9.92410  1.000 26.68068 ? 1814 GLN A HE21 1 
ATOM   5809 H  HE22 . GLN A 1 355 ? -1.83593  -36.97673 -9.12453  1.000 26.68068 ? 1814 GLN A HE22 1 
ATOM   5810 N  N    . GLY A 1 356 ? -1.79503  -31.94806 -5.62363  1.000 15.43849 ? 1815 GLY A N    1 
ATOM   5811 C  CA   . GLY A 1 356 ? -2.82137  -30.93937 -5.42238  1.000 14.19624 ? 1815 GLY A CA   1 
ATOM   5812 C  C    . GLY A 1 356 ? -2.74138  -30.14631 -4.14628  1.000 13.91728 ? 1815 GLY A C    1 
ATOM   5813 O  O    . GLY A 1 356 ? -3.56140  -29.23246 -3.95862  1.000 15.39370 ? 1815 GLY A O    1 
ATOM   5814 H  H    . GLY A 1 356 ? -1.97341  -32.69278 -5.23225  1.000 18.52619 ? 1815 GLY A H    1 
ATOM   5815 H  HA2  . GLY A 1 356 ? -2.77608  -30.30859 -6.15788  1.000 17.03549 ? 1815 GLY A HA2  1 
ATOM   5816 H  HA3  . GLY A 1 356 ? -3.68612  -31.37861 -5.43585  1.000 17.03549 ? 1815 GLY A HA3  1 
ATOM   5817 N  N    . ALA A 1 357 ? -1.76834  -30.41575 -3.26970  1.000 14.12786 ? 1816 ALA A N    1 
ATOM   5818 C  CA   . ALA A 1 357 ? -1.57161  -29.61576 -2.07397  1.000 15.82537 ? 1816 ALA A CA   1 
ATOM   5819 C  C    . ALA A 1 357 ? -0.88713  -28.30222 -2.45144  1.000 15.92011 ? 1816 ALA A C    1 
ATOM   5820 O  O    . ALA A 1 357 ? -0.05906  -28.23934 -3.36920  1.000 17.08597 ? 1816 ALA A O    1 
ATOM   5821 C  CB   . ALA A 1 357 ? -0.71711  -30.37290 -1.06768  1.000 18.57554 ? 1816 ALA A CB   1 
ATOM   5822 H  H    . ALA A 1 357 ? -1.20813  -31.06309 -3.35173  1.000 16.95343 ? 1816 ALA A H    1 
ATOM   5823 H  HA   . ALA A 1 357 ? -2.42538  -29.42124 -1.65665  1.000 18.99045 ? 1816 ALA A HA   1 
ATOM   5824 H  HB1  . ALA A 1 357 ? -0.59978  -29.82390 -0.27664  1.000 22.29064 ? 1816 ALA A HB1  1 
ATOM   5825 H  HB2  . ALA A 1 357 ? -1.16500  -31.20053 -0.83246  1.000 22.29064 ? 1816 ALA A HB2  1 
ATOM   5826 H  HB3  . ALA A 1 357 ? 0.14540   -30.56561 -1.46748  1.000 22.29064 ? 1816 ALA A HB3  1 
ATOM   5827 N  N    . VAL A 1 358 ? -1.25030  -27.24798 -1.75969  1.000 16.79386 ? 1817 VAL A N    1 
ATOM   5828 C  CA   . VAL A 1 358 ? -0.62572  -25.95382 -2.04786  1.000 16.37017 ? 1817 VAL A CA   1 
ATOM   5829 C  C    . VAL A 1 358 ? 0.73189   -25.91477 -1.34968  1.000 15.72808 ? 1817 VAL A C    1 
ATOM   5830 O  O    . VAL A 1 358 ? 0.79520   -26.12110 -0.12664  1.000 16.08065 ? 1817 VAL A O    1 
ATOM   5831 C  CB   . VAL A 1 358 ? -1.50668  -24.80482 -1.58180  1.000 15.44640 ? 1817 VAL A CB   1 
ATOM   5832 C  CG1  . VAL A 1 358 ? -0.82693  -23.46706 -1.92213  1.000 15.41475 ? 1817 VAL A CG1  1 
ATOM   5833 C  CG2  . VAL A 1 358 ? -2.91878  -24.86427 -2.16764  1.000 16.31482 ? 1817 VAL A CG2  1 
ATOM   5834 H  H    . VAL A 1 358 ? -1.83896  -27.24291 -1.13274  1.000 20.15263 ? 1817 VAL A H    1 
ATOM   5835 H  HA   . VAL A 1 358 ? -0.49802  -25.86462 -3.00527  1.000 19.64420 ? 1817 VAL A HA   1 
ATOM   5836 H  HB   . VAL A 1 358 ? -1.61407  -24.87855 -0.62058  1.000 18.53568 ? 1817 VAL A HB   1 
ATOM   5837 H  HG11 . VAL A 1 358 ? -0.06039  -23.34532 -1.34033  1.000 18.49770 ? 1817 VAL A HG11 1 
ATOM   5838 H  HG12 . VAL A 1 358 ? -0.53954  -23.48551 -2.84840  1.000 18.49770 ? 1817 VAL A HG12 1 
ATOM   5839 H  HG13 . VAL A 1 358 ? -1.46232  -22.74665 -1.78722  1.000 18.49770 ? 1817 VAL A HG13 1 
ATOM   5840 H  HG21 . VAL A 1 358 ? -3.40574  -24.06945 -1.89926  1.000 19.57778 ? 1817 VAL A HG21 1 
ATOM   5841 H  HG22 . VAL A 1 358 ? -2.85797  -24.90408 -3.13491  1.000 19.57778 ? 1817 VAL A HG22 1 
ATOM   5842 H  HG23 . VAL A 1 358 ? -3.36705  -25.65609 -1.83151  1.000 19.57778 ? 1817 VAL A HG23 1 
ATOM   5843 N  N    . PRO A 1 359 ? 1.81997   -25.65306 -2.07123  1.000 17.63607 ? 1818 PRO A N    1 
ATOM   5844 C  CA   . PRO A 1 359 ? 3.13345   -25.63191 -1.40859  1.000 17.80984 ? 1818 PRO A CA   1 
ATOM   5845 C  C    . PRO A 1 359 ? 3.19627   -24.56160 -0.32280  1.000 16.79395 ? 1818 PRO A C    1 
ATOM   5846 O  O    . PRO A 1 359 ? 2.63165   -23.48461 -0.46830  1.000 16.63338 ? 1818 PRO A O    1 
ATOM   5847 C  CB   . PRO A 1 359 ? 4.11036   -25.34580 -2.55219  1.000 20.82586 ? 1818 PRO A CB   1 
ATOM   5848 C  CG   . PRO A 1 359 ? 3.40579   -25.86569 -3.75309  1.000 21.86541 ? 1818 PRO A CG   1 
ATOM   5849 C  CD   . PRO A 1 359 ? 1.93132   -25.45051 -3.50910  1.000 19.78104 ? 1818 PRO A CD   1 
ATOM   5850 H  HA   . PRO A 1 359 ? 3.33469   -26.49786 -1.02061  1.000 21.37181 ? 1818 PRO A HA   1 
ATOM   5851 H  HB2  . PRO A 1 359 ? 4.27255   -24.39219 -2.62444  1.000 24.99103 ? 1818 PRO A HB2  1 
ATOM   5852 H  HB3  . PRO A 1 359 ? 4.94673   -25.81432 -2.40431  1.000 24.99103 ? 1818 PRO A HB3  1 
ATOM   5853 H  HG2  . PRO A 1 359 ? 3.75994   -25.45397 -4.55681  1.000 26.23849 ? 1818 PRO A HG2  1 
ATOM   5854 H  HG3  . PRO A 1 359 ? 3.49662   -26.82995 -3.80663  1.000 26.23849 ? 1818 PRO A HG3  1 
ATOM   5855 H  HD2  . PRO A 1 359 ? 1.78066   -24.52267 -3.74851  1.000 23.73725 ? 1818 PRO A HD2  1 
ATOM   5856 H  HD3  . PRO A 1 359 ? 1.31741   -26.02257 -3.99568  1.000 23.73725 ? 1818 PRO A HD3  1 
ATOM   5857 N  N    . GLN A 1 360 ? 3.90750   -24.86029 0.77298   1.000 18.48888 ? 1819 GLN A N    1 
ATOM   5858 C  CA   . GLN A 1 360 ? 4.13139   -23.86335 1.81878   1.000 19.84431 ? 1819 GLN A CA   1 
ATOM   5859 C  C    . GLN A 1 360 ? 5.48417   -24.07786 2.46347   1.000 22.01290 ? 1819 GLN A C    1 
ATOM   5860 O  O    . GLN A 1 360 ? 6.04072   -25.17047 2.42058   1.000 22.51297 ? 1819 GLN A O    1 
ATOM   5861 C  CB   . GLN A 1 360 ? 3.02615   -23.89752 2.90514   1.000 21.50759 ? 1819 GLN A CB   1 
ATOM   5862 C  CG   . GLN A 1 360 ? 3.08171   -25.10170 3.76632   1.000 23.60526 ? 1819 GLN A CG   1 
ATOM   5863 C  CD   . GLN A 1 360 ? 1.97471   -25.15649 4.79250   1.000 26.38713 ? 1819 GLN A CD   1 
ATOM   5864 O  OE1  . GLN A 1 360 ? 1.89408   -24.29641 5.66425   1.000 28.50044 ? 1819 GLN A OE1  1 
ATOM   5865 N  NE2  . GLN A 1 360 ? 1.12556   -26.14704 4.67979   1.000 26.96086 ? 1819 GLN A NE2  1 
ATOM   5866 H  H    . GLN A 1 360 ? 4.26549   -25.62653 0.92890   1.000 22.18666 ? 1819 GLN A H    1 
ATOM   5867 H  HA   . GLN A 1 360 ? 4.13101   -22.98877 1.39925   1.000 23.81317 ? 1819 GLN A HA   1 
ATOM   5868 H  HB2  . GLN A 1 360 ? 3.12414   -23.11922 3.47570   1.000 25.80911 ? 1819 GLN A HB2  1 
ATOM   5869 H  HB3  . GLN A 1 360 ? 2.15931   -23.88292 2.47008   1.000 25.80911 ? 1819 GLN A HB3  1 
ATOM   5870 H  HG2  . GLN A 1 360 ? 3.00804   -25.89089 3.20717   1.000 28.32632 ? 1819 GLN A HG2  1 
ATOM   5871 H  HG3  . GLN A 1 360 ? 3.92764   -25.10916 4.24093   1.000 28.32632 ? 1819 GLN A HG3  1 
ATOM   5872 H  HE21 . GLN A 1 360 ? 1.21655   -26.72144 4.04623   1.000 32.35303 ? 1819 GLN A HE21 1 
ATOM   5873 H  HE22 . GLN A 1 360 ? 0.47692   -26.22315 5.23932   1.000 32.35303 ? 1819 GLN A HE22 1 
ATOM   5874 N  N    . LEU A 1 361 ? 5.97692   -23.01774 3.08507   1.000 22.85254 ? 1820 LEU A N    1 
ATOM   5875 C  CA   . LEU A 1 361 ? 7.15834   -23.12400 3.93685   1.000 25.08703 ? 1820 LEU A CA   1 
ATOM   5876 C  C    . LEU A 1 361 ? 6.82298   -23.94847 5.18506   1.000 27.72417 ? 1820 LEU A C    1 
ATOM   5877 O  O    . LEU A 1 361 ? 5.69267   -23.92460 5.66894   1.000 28.88473 ? 1820 LEU A O    1 
ATOM   5878 C  CB   . LEU A 1 361 ? 7.63602   -21.72868 4.35008   1.000 26.05552 ? 1820 LEU A CB   1 
ATOM   5879 C  CG   . LEU A 1 361 ? 8.03996   -20.78846 3.22967   1.000 27.45831 ? 1820 LEU A CG   1 
ATOM   5880 C  CD1  . LEU A 1 361 ? 8.48759   -19.44335 3.77788   1.000 29.51639 ? 1820 LEU A CD1  1 
ATOM   5881 C  CD2  . LEU A 1 361 ? 9.15064   -21.39199 2.40104   1.000 26.43980 ? 1820 LEU A CD2  1 
ATOM   5882 H  H    . LEU A 1 361 ? 5.64920   -22.22434 3.03300   1.000 27.42305 ? 1820 LEU A H    1 
ATOM   5883 H  HA   . LEU A 1 361 ? 7.87842   -23.56358 3.45814   1.000 30.10443 ? 1820 LEU A HA   1 
ATOM   5884 H  HB2  . LEU A 1 361 ? 6.91675   -21.29766 4.83770   1.000 31.26662 ? 1820 LEU A HB2  1 
ATOM   5885 H  HB3  . LEU A 1 361 ? 8.40983   -21.83474 4.92529   1.000 31.26662 ? 1820 LEU A HB3  1 
ATOM   5886 H  HG   . LEU A 1 361 ? 7.26658   -20.64581 2.66184   1.000 32.94998 ? 1820 LEU A HG   1 
ATOM   5887 H  HD11 . LEU A 1 361 ? 8.73462   -18.86707 3.03776   1.000 35.41967 ? 1820 LEU A HD11 1 
ATOM   5888 H  HD12 . LEU A 1 361 ? 7.75634   -19.04634 4.27644   1.000 35.41967 ? 1820 LEU A HD12 1 
ATOM   5889 H  HD13 . LEU A 1 361 ? 9.25081   -19.57820 4.36115   1.000 35.41967 ? 1820 LEU A HD13 1 
ATOM   5890 H  HD21 . LEU A 1 361 ? 9.46353   -20.73147 1.76330   1.000 31.72776 ? 1820 LEU A HD21 1 
ATOM   5891 H  HD22 . LEU A 1 361 ? 9.87644   -21.65411 2.98876   1.000 31.72776 ? 1820 LEU A HD22 1 
ATOM   5892 H  HD23 . LEU A 1 361 ? 8.80815   -22.16871 1.93165   1.000 31.72776 ? 1820 LEU A HD23 1 
ATOM   5893 N  N    . PRO A 1 362 ? 7.79312   -24.70812 5.72149   1.000 30.13501 ? 1821 PRO A N    1 
ATOM   5894 C  CA   . PRO A 1 362 ? 7.50616   -25.48894 6.93520   1.000 33.92224 ? 1821 PRO A CA   1 
ATOM   5895 C  C    . PRO A 1 362 ? 7.11354   -24.60707 8.13304   1.000 37.17790 ? 1821 PRO A C    1 
ATOM   5896 O  O    . PRO A 1 362 ? 7.63737   -23.50353 8.31038   1.000 37.72795 ? 1821 PRO A O    1 
ATOM   5897 C  CB   . PRO A 1 362 ? 8.83154   -26.21363 7.21833   1.000 33.79588 ? 1821 PRO A CB   1 
ATOM   5898 C  CG   . PRO A 1 362 ? 9.65001   -26.07401 6.00341   1.000 32.79314 ? 1821 PRO A CG   1 
ATOM   5899 C  CD   . PRO A 1 362 ? 9.17878   -24.83812 5.27350   1.000 31.25879 ? 1821 PRO A CD   1 
ATOM   5900 O  OXT  . PRO A 1 362 ? 6.27549   -24.98449 8.96009   1.000 40.06235 ? 1821 PRO A OXT  1 
ATOM   5901 H  HA   . PRO A 1 362 ? 6.80606   -26.13785 6.76293   1.000 40.70669 ? 1821 PRO A HA   1 
ATOM   5902 H  HB2  . PRO A 1 362 ? 9.27204   -25.79942 7.97681   1.000 40.55505 ? 1821 PRO A HB2  1 
ATOM   5903 H  HB3  . PRO A 1 362 ? 8.65599   -27.14882 7.40671   1.000 40.55505 ? 1821 PRO A HB3  1 
ATOM   5904 H  HG2  . PRO A 1 362 ? 10.58236  -25.98196 6.25472   1.000 39.35177 ? 1821 PRO A HG2  1 
ATOM   5905 H  HG3  . PRO A 1 362 ? 9.53250   -26.85953 5.44660   1.000 39.35177 ? 1821 PRO A HG3  1 
ATOM   5906 H  HD2  . PRO A 1 362 ? 9.70124   -24.06237 5.53070   1.000 37.51055 ? 1821 PRO A HD2  1 
ATOM   5907 H  HD3  . PRO A 1 362 ? 9.22287   -24.96410 4.31272   1.000 37.51055 ? 1821 PRO A HD3  1 
HETATM 5908 ZN ZN   . ZN  B 2 .   ? -21.10997 -17.40111 -7.06377  1.000 10.02868 ? 1901 ZN  A ZN   1 
HETATM 5909 ZN ZN   . ZN  C 2 .   ? -20.87985 -13.95165 -5.99862  0.964 9.72289  ? 1902 ZN  A ZN   1 
HETATM 5910 C  C6   A NCD D 3 .   ? -25.03784 -16.85265 -6.85281  0.603 9.99299  ? 1903 NCD A C6   1 
HETATM 5911 C  C61  A NCD D 3 .   ? -25.87423 -18.09376 -6.36527  0.603 8.06919  ? 1903 NCD A C61  1 
HETATM 5912 O  O61  A NCD D 3 .   ? -25.25793 -18.88270 -5.64900  0.603 7.96650  ? 1903 NCD A O61  1 
HETATM 5913 O  O62  A NCD D 3 .   ? -27.05803 -18.19626 -6.78640  0.603 8.80870  ? 1903 NCD A O62  1 
HETATM 5914 N  N1   A NCD D 3 .   ? -26.00931 -15.90345 -7.38785  0.603 7.75082  ? 1903 NCD A N1   1 
HETATM 5915 C  C2   A NCD D 3 .   ? -25.66292 -14.86587 -8.18390  0.603 9.15339  ? 1903 NCD A C2   1 
HETATM 5916 O  O2   A NCD D 3 .   ? -26.52933 -14.10699 -8.61835  0.603 7.74021  ? 1903 NCD A O2   1 
HETATM 5917 N  N3   A NCD D 3 .   ? -24.38354 -14.62628 -8.50210  0.603 10.15622 ? 1903 NCD A N3   1 
HETATM 5918 C  C5   A NCD D 3 .   ? -24.12935 -16.35939 -5.73124  0.603 11.75887 ? 1903 NCD A C5   1 
HETATM 5919 C  C4   A NCD D 3 .   ? -22.92856 -15.42806 -6.09693  0.603 9.43775  ? 1903 NCD A C4   1 
HETATM 5920 O  O4   A NCD D 3 .   ? -21.97399 -15.72416 -6.88100  0.603 7.06651  ? 1903 NCD A O4   1 
HETATM 5921 O  O5   A NCD D 3 .   ? -22.90967 -14.32547 -5.52104  0.603 10.08515 ? 1903 NCD A O5   1 
HETATM 5922 H  H61  A NCD D 3 .   ? -24.36562 -17.01521 -7.53295  0.603 11.99159 ? 1903 NCD A H61  1 
HETATM 5923 H  H11  A NCD D 3 .   ? -26.81860 -16.24462 -7.53192  0.603 9.30099  ? 1903 NCD A H11  1 
HETATM 5924 H  H31  A NCD D 3 .   ? -23.74785 -15.17884 -8.22449  0.603 12.18746 ? 1903 NCD A H31  1 
HETATM 5925 H  H32  A NCD D 3 .   ? -24.13289 -13.94978 -9.03032  0.603 12.18746 ? 1903 NCD A H32  1 
HETATM 5926 H  H51  A NCD D 3 .   ? -23.77920 -17.14028 -5.27461  0.603 14.11064 ? 1903 NCD A H51  1 
HETATM 5927 H  H52  A NCD D 3 .   ? -24.68681 -15.89622 -5.08656  0.603 14.11064 ? 1903 NCD A H52  1 
HETATM 5928 ZN ZN   . ZN  E 2 .   ? -15.28067 -16.54730 -8.02616  0.251 9.48776  ? 1904 ZN  A ZN   1 
HETATM 5929 O  O2   B DOR F 4 .   ? -26.29120 -14.42926 -9.04679  0.443 12.36964 ? 1905 DOR A O2   1 
HETATM 5930 C  C2   B DOR F 4 .   ? -25.77271 -14.90432 -8.06982  0.443 12.71960 ? 1905 DOR A C2   1 
HETATM 5931 N  N1   B DOR F 4 .   ? -26.03307 -16.28299 -7.70329  0.443 12.73029 ? 1905 DOR A N1   1 
HETATM 5932 N  N3   B DOR F 4 .   ? -24.83232 -14.16311 -7.18873  0.443 10.18256 ? 1905 DOR A N3   1 
HETATM 5933 C  C4   B DOR F 4 .   ? -24.32369 -14.62559 -5.97577  0.443 9.17998  ? 1905 DOR A C4   1 
HETATM 5934 O  O4   B DOR F 4 .   ? -23.65358 -13.90206 -5.32570  0.443 10.08780 ? 1905 DOR A O4   1 
HETATM 5935 C  C5   B DOR F 4 .   ? -24.56375 -16.03262 -5.58903  0.443 12.32484 ? 1905 DOR A C5   1 
HETATM 5936 C  C6   B DOR F 4 .   ? -25.33177 -16.89063 -6.53363  0.443 13.19606 ? 1905 DOR A C6   1 
HETATM 5937 C  C7   B DOR F 4 .   ? -26.16438 -18.04454 -5.85788  0.443 13.41978 ? 1905 DOR A C7   1 
HETATM 5938 O  O72  B DOR F 4 .   ? -25.60329 -18.78962 -4.98659  0.443 13.58031 ? 1905 DOR A O72  1 
HETATM 5939 O  O71  B DOR F 4 .   ? -27.33584 -18.22136 -6.23730  0.443 13.35660 ? 1905 DOR A O71  1 
HETATM 5940 H  HN1  B DOR F 4 .   ? -26.59177 -16.75089 -8.15992  0.443 15.27634 ? 1905 DOR A HN1  1 
HETATM 5941 H  HN3  B DOR F 4 .   ? -24.58078 -13.38307 -7.44925  0.443 12.21908 ? 1905 DOR A HN3  1 
HETATM 5942 H  H51  B DOR F 4 .   ? -25.09310 -15.99579 -4.77703  0.443 14.78980 ? 1905 DOR A H51  1 
HETATM 5943 H  H52  B DOR F 4 .   ? -23.68609 -16.43951 -5.51798  0.443 14.78980 ? 1905 DOR A H52  1 
HETATM 5944 H  H6   B DOR F 4 .   ? -24.66553 -17.45972 -6.94976  0.443 15.83527 ? 1905 DOR A H6   1 
HETATM 5945 C  C    . FMT G 5 .   ? -5.84980  -15.00611 -3.88987  1.000 18.02046 ? 1906 FMT A C    1 
HETATM 5946 O  O1   . FMT G 5 .   ? -5.63783  -15.53312 -2.86826  1.000 17.65188 ? 1906 FMT A O1   1 
HETATM 5947 O  O2   . FMT G 5 .   ? -4.97609  -14.30285 -4.44493  1.000 21.74696 ? 1906 FMT A O2   1 
HETATM 5948 H  H    . FMT G 5 .   ? -6.81052  -15.10162 -4.39704  1.000 21.62455 ? 1906 FMT A H    1 
HETATM 5949 H  HO2  . FMT G 5 .   ? -4.04675  -14.34197 -4.13638  1.000 26.09636 ? 1906 FMT A HO2  1 
HETATM 5950 C  C    . FMT H 5 .   ? 0.23250   -23.73420 -15.25078 0.489 9.18238  ? 1907 FMT A C    1 
HETATM 5951 O  O1   . FMT H 5 .   ? 0.43715   -24.40023 -14.21881 0.489 7.56916  ? 1907 FMT A O1   1 
HETATM 5952 O  O2   . FMT H 5 .   ? -0.20811  -24.18811 -16.30473 0.489 11.17212 ? 1907 FMT A O2   1 
HETATM 5953 H  H    . FMT H 5 .   ? 0.44948   -22.65923 -15.22763 0.489 11.01886 ? 1907 FMT A H    1 
HETATM 5954 H  HO2  . FMT H 5 .   ? -0.96265  -24.81333 -16.29152 0.489 13.40655 ? 1907 FMT A HO2  1 
HETATM 5955 C  C    . FMT I 5 .   ? -0.27708  -1.07754  3.15556   1.000 37.09106 ? 1908 FMT A C    1 
HETATM 5956 O  O1   . FMT I 5 .   ? 0.87769   -0.77710  3.41036   1.000 37.35683 ? 1908 FMT A O1   1 
HETATM 5957 O  O2   . FMT I 5 .   ? -1.09491  -1.24118  4.05413   1.000 37.24899 ? 1908 FMT A O2   1 
HETATM 5958 H  H    . FMT I 5 .   ? -0.56364  -1.35664  2.14433   1.000 44.50927 ? 1908 FMT A H    1 
HETATM 5959 H  HO2  . FMT I 5 .   ? -0.84707  -1.05069  4.98294   1.000 44.69879 ? 1908 FMT A HO2  1 
HETATM 5960 C  C    . FMT J 5 .   ? -23.71969 -15.11813 -28.86867 1.000 41.22308 ? 1909 FMT A C    1 
HETATM 5961 O  O1   . FMT J 5 .   ? -24.06772 -14.59931 -29.95742 1.000 41.70475 ? 1909 FMT A O1   1 
HETATM 5962 O  O2   . FMT J 5 .   ? -23.49460 -14.45388 -27.82075 1.000 39.79405 ? 1909 FMT A O2   1 
HETATM 5963 H  H    . FMT J 5 .   ? -23.59727 -16.19860 -28.80721 1.000 49.46770 ? 1909 FMT A H    1 
HETATM 5964 H  HO2  . FMT J 5 .   ? -23.59147 -13.47871 -27.82846 1.000 47.75286 ? 1909 FMT A HO2  1 
HETATM 5965 C  C    . FMT K 5 .   ? -43.97180 -9.43325  -4.76496  1.000 49.93731 ? 1910 FMT A C    1 
HETATM 5966 O  O1   . FMT K 5 .   ? -43.54231 -10.58137 -4.93902  1.000 49.34517 ? 1910 FMT A O1   1 
HETATM 5967 O  O2   . FMT K 5 .   ? -43.39572 -8.44170  -5.22592  1.000 50.31104 ? 1910 FMT A O2   1 
HETATM 5968 H  H    . FMT K 5 .   ? -44.89360 -9.26459  -4.20840  1.000 59.92478 ? 1910 FMT A H    1 
HETATM 5969 H  HO2  . FMT K 5 .   ? -42.56728 -8.55033  -5.73806  1.000 60.37325 ? 1910 FMT A HO2  1 
HETATM 5970 C  C    . FMT L 5 .   ? -7.53395  -35.21266 -29.49257 1.000 46.37903 ? 1911 FMT A C    1 
HETATM 5971 O  O1   . FMT L 5 .   ? -6.48052  -35.88139 -29.47198 1.000 47.17906 ? 1911 FMT A O1   1 
HETATM 5972 O  O2   . FMT L 5 .   ? -7.94916  -34.65665 -30.51259 1.000 46.28690 ? 1911 FMT A O2   1 
HETATM 5973 H  H    . FMT L 5 .   ? -8.10001  -35.04264 -28.57616 1.000 55.65483 ? 1911 FMT A H    1 
HETATM 5974 H  HO2  . FMT L 5 .   ? -7.44657  -34.73143 -31.35057 1.000 55.54428 ? 1911 FMT A HO2  1 
HETATM 5975 C  C    . FMT M 5 .   ? 1.83132   -28.59467 1.36192   1.000 49.04512 ? 1912 FMT A C    1 
HETATM 5976 O  O1   . FMT M 5 .   ? 2.21345   -28.51690 0.19319   1.000 49.96098 ? 1912 FMT A O1   1 
HETATM 5977 O  O2   . FMT M 5 .   ? 1.71590   -27.59693 2.06835   1.000 48.48981 ? 1912 FMT A O2   1 
HETATM 5978 H  H    . FMT M 5 .   ? 1.56602   -29.55860 1.79929   1.000 58.85414 ? 1912 FMT A H    1 
HETATM 5979 H  HO2  . FMT M 5 .   ? 1.88295   -26.70780 1.69160   1.000 58.18777 ? 1912 FMT A HO2  1 
HETATM 5980 ZN ZN   . ZN  N 2 .   ? 1.19411   -24.46062 -8.15588  0.589 12.17472 ? 1913 ZN  A ZN   1 
HETATM 5981 C  C    . FMT O 5 .   ? -24.09787 -42.26602 -16.82517 1.000 32.15374 ? 1914 FMT A C    1 
HETATM 5982 O  O1   . FMT O 5 .   ? -24.36679 -41.89397 -15.65903 1.000 33.45114 ? 1914 FMT A O1   1 
HETATM 5983 O  O2   . FMT O 5 .   ? -23.16660 -43.07124 -17.05919 1.000 35.26179 ? 1914 FMT A O2   1 
HETATM 5984 H  H    . FMT O 5 .   ? -24.66396 -41.89044 -17.67826 1.000 38.58448 ? 1914 FMT A H    1 
HETATM 5985 H  HO2  . FMT O 5 .   ? -22.62443 -43.42115 -16.32162 1.000 42.31415 ? 1914 FMT A HO2  1 
HETATM 5986 C  C    . FMT P 5 .   ? -21.81950 -28.61381 13.42621  0.656 31.10882 ? 1915 FMT A C    1 
HETATM 5987 O  O1   . FMT P 5 .   ? -20.71635 -28.05808 13.46867  0.656 32.29043 ? 1915 FMT A O1   1 
HETATM 5988 O  O2   . FMT P 5 .   ? -21.93809 -29.81323 13.18160  0.656 32.17465 ? 1915 FMT A O2   1 
HETATM 5989 H  H    . FMT P 5 .   ? -22.73185 -28.04525 13.60397  0.656 37.33059 ? 1915 FMT A H    1 
HETATM 5990 H  HO2  . FMT P 5 .   ? -21.14242 -30.35998 13.01317  0.656 38.60958 ? 1915 FMT A HO2  1 
HETATM 5991 C  C    . FMT Q 5 .   ? -3.89882  -31.67029 -23.52801 1.000 20.05239 ? 1916 FMT A C    1 
HETATM 5992 O  O1   . FMT Q 5 .   ? -4.00068  -31.53109 -24.73953 1.000 21.94705 ? 1916 FMT A O1   1 
HETATM 5993 O  O2   . FMT Q 5 .   ? -3.87303  -32.83540 -22.96301 1.000 21.27857 ? 1916 FMT A O2   1 
HETATM 5994 H  H    . FMT Q 5 .   ? -3.85469  -30.77406 -22.90848 1.000 24.06287 ? 1916 FMT A H    1 
HETATM 5995 H  HO2  . FMT Q 5 .   ? -3.17199  -33.47857 -23.19812 1.000 25.53428 ? 1916 FMT A HO2  1 
HETATM 5996 C  C    . FMT R 5 .   ? -2.58627  -17.02829 -33.03999 0.809 45.13151 ? 1917 FMT A C    1 
HETATM 5997 O  O1   . FMT R 5 .   ? -3.06894  -17.40545 -34.10294 0.809 45.39468 ? 1917 FMT A O1   1 
HETATM 5998 O  O2   . FMT R 5 .   ? -2.52838  -15.83514 -32.73036 0.809 45.66573 ? 1917 FMT A O2   1 
HETATM 5999 H  H    . FMT R 5 .   ? -2.13858  -17.74890 -32.35929 0.809 54.15781 ? 1917 FMT A H    1 
HETATM 6000 H  HO2  . FMT R 5 .   ? -2.87787  -15.15294 -33.34099 0.809 54.79887 ? 1917 FMT A HO2  1 
HETATM 6001 O  O    . HOH S 6 .   ? -3.59016  -3.41346  -18.94907 1.000 35.67246 ? 2001 HOH A O    1 
HETATM 6002 O  O    . HOH S 6 .   ? -26.01334 -41.28520 -14.12902 1.000 35.71457 ? 2002 HOH A O    1 
HETATM 6003 O  O    . HOH S 6 .   ? -25.49884 -12.75356 -30.05698 1.000 37.28845 ? 2003 HOH A O    1 
HETATM 6004 O  O    . HOH S 6 .   ? -15.30120 -43.22129 -7.32070  1.000 23.90789 ? 2004 HOH A O    1 
HETATM 6005 O  O    . HOH S 6 .   ? -15.12767 -40.10466 -6.37539  1.000 15.60949 ? 2005 HOH A O    1 
HETATM 6006 O  O    . HOH S 6 .   ? 3.22879   -22.42739 6.21019   1.000 44.54194 ? 2006 HOH A O    1 
HETATM 6007 O  O    . HOH S 6 .   ? -29.47137 -5.71393  -9.12738  1.000 31.86410 ? 2007 HOH A O    1 
HETATM 6008 O  O    . HOH S 6 .   ? -28.83561 -12.95427 0.98356   1.000 30.00336 ? 2008 HOH A O    1 
HETATM 6009 O  O    . HOH S 6 .   ? -14.00806 0.87348   -22.42653 1.000 27.73203 ? 2009 HOH A O    1 
HETATM 6010 O  O    . HOH S 6 .   ? -21.68188 -14.94508 9.05632   1.000 25.33437 ? 2010 HOH A O    1 
HETATM 6011 O  O    . HOH S 6 .   ? -2.69118  -19.12218 -2.88321  1.000 31.20613 ? 2011 HOH A O    1 
HETATM 6012 O  O    . HOH S 6 .   ? -4.73676  -42.92518 -18.61851 1.000 39.18340 ? 2012 HOH A O    1 
HETATM 6013 O  O    . HOH S 6 .   ? -23.33757 -15.64441 -33.26420 1.000 30.99821 ? 2013 HOH A O    1 
HETATM 6014 O  O    . HOH S 6 .   ? -15.05514 -45.64078 -18.38739 1.000 34.03015 ? 2014 HOH A O    1 
HETATM 6015 O  O    . HOH S 6 .   ? -17.50462 -11.56477 14.04726  1.000 36.76732 ? 2015 HOH A O    1 
HETATM 6016 O  O    . HOH S 6 .   ? -12.71734 -32.60076 5.84918   1.000 41.27050 ? 2016 HOH A O    1 
HETATM 6017 O  O    . HOH S 6 .   ? -2.89568  -18.51440 10.22848  1.000 41.04678 ? 2017 HOH A O    1 
HETATM 6018 O  O    . HOH S 6 .   ? -27.17198 -34.13569 -23.87770 1.000 32.61156 ? 2018 HOH A O    1 
HETATM 6019 O  O    . HOH S 6 .   ? -13.01269 -27.49916 -35.53771 1.000 28.60845 ? 2019 HOH A O    1 
HETATM 6020 O  O    . HOH S 6 .   ? -5.65237  -6.01670  12.94513  1.000 28.50581 ? 2020 HOH A O    1 
HETATM 6021 O  O    . HOH S 6 .   ? -14.03854 -8.50269  16.10249  1.000 43.40759 ? 2021 HOH A O    1 
HETATM 6022 O  O    . HOH S 6 .   ? -40.42310 -22.60886 -4.86371  1.000 38.59912 ? 2022 HOH A O    1 
HETATM 6023 O  O    . HOH S 6 .   ? -37.90472 -23.10041 -3.74912  1.000 30.75608 ? 2023 HOH A O    1 
HETATM 6024 O  O    . HOH S 6 .   ? -17.14968 3.85820   -21.64157 1.000 34.44863 ? 2024 HOH A O    1 
HETATM 6025 O  O    . HOH S 6 .   ? -34.81835 -20.36216 -20.75153 1.000 16.41225 ? 2025 HOH A O    1 
HETATM 6026 O  O    . HOH S 6 .   ? -43.84008 -19.39831 -7.78580  1.000 29.57962 ? 2026 HOH A O    1 
HETATM 6027 O  O    . HOH S 6 .   ? -21.92749 -13.27607 -32.19085 1.000 26.25554 ? 2027 HOH A O    1 
HETATM 6028 O  O    . HOH S 6 .   ? -1.20801  -15.17766 -23.45851 1.000 26.40818 ? 2028 HOH A O    1 
HETATM 6029 O  O    . HOH S 6 .   ? -1.95297  -34.71518 -11.52237 1.000 27.38198 ? 2029 HOH A O    1 
HETATM 6030 O  O    . HOH S 6 .   ? -30.91732 -0.95821  -22.73658 1.000 38.29382 ? 2030 HOH A O    1 
HETATM 6031 O  O    . HOH S 6 .   ? -35.98623 -21.25319 -27.96227 1.000 28.07681 ? 2031 HOH A O    1 
HETATM 6032 O  O    . HOH S 6 .   ? -22.79481 -13.68392 -11.47176 1.000 16.33592 ? 2032 HOH A O    1 
HETATM 6033 O  O    . HOH S 6 .   ? -7.78315  -45.47278 -20.71959 1.000 41.41525 ? 2033 HOH A O    1 
HETATM 6034 O  O    . HOH S 6 .   ? -13.03453 -38.92516 1.66200   1.000 27.62939 ? 2034 HOH A O    1 
HETATM 6035 O  O    . HOH S 6 .   ? -35.27807 -29.28107 -12.90100 1.000 24.67114 ? 2035 HOH A O    1 
HETATM 6036 O  O    . HOH S 6 .   ? -30.90241 -26.96767 -18.11976 1.000 12.99868 ? 2036 HOH A O    1 
HETATM 6037 O  O    . HOH S 6 .   ? -39.41707 -13.65161 -17.88639 1.000 25.21857 ? 2037 HOH A O    1 
HETATM 6038 O  O    . HOH S 6 .   ? -25.11441 -5.87822  -8.57202  1.000 12.75128 ? 2038 HOH A O    1 
HETATM 6039 O  O    . HOH S 6 .   ? -31.56423 -19.06538 -34.52561 1.000 32.84581 ? 2039 HOH A O    1 
HETATM 6040 O  O    . HOH S 6 .   ? -29.73621 -35.22614 -5.21321  1.000 30.86925 ? 2040 HOH A O    1 
HETATM 6041 O  O    . HOH S 6 .   ? -24.97167 -7.18267  -4.54606  1.000 22.72353 ? 2041 HOH A O    1 
HETATM 6042 O  O    . HOH S 6 .   ? -7.00162  -11.67660 13.81739  1.000 32.79053 ? 2042 HOH A O    1 
HETATM 6043 O  O    . HOH S 6 .   ? -20.28248 -15.79882 -35.19454 1.000 34.97500 ? 2043 HOH A O    1 
HETATM 6044 O  O    . HOH S 6 .   ? -16.80383 1.26378   -22.26736 1.000 22.35507 ? 2044 HOH A O    1 
HETATM 6045 O  O    . HOH S 6 .   ? -10.57881 -45.05028 -22.45214 1.000 36.36465 ? 2045 HOH A O    1 
HETATM 6046 O  O    . HOH S 6 .   ? -28.05984 0.28400   -24.41446 1.000 39.42554 ? 2046 HOH A O    1 
HETATM 6047 O  O    . HOH S 6 .   ? -12.37036 -35.25454 -0.03414  1.000 30.59551 ? 2047 HOH A O    1 
HETATM 6048 O  O    . HOH S 6 .   ? -2.21310  -16.72833 -30.24759 1.000 23.62627 ? 2048 HOH A O    1 
HETATM 6049 O  O    . HOH S 6 .   ? -4.46434  -15.05103 4.83403   1.000 16.00957 ? 2049 HOH A O    1 
HETATM 6050 O  O    . HOH S 6 .   ? -15.35057 -23.52567 12.47107  1.000 29.16641 ? 2050 HOH A O    1 
HETATM 6051 O  O    . HOH S 6 .   ? -4.45012  -29.25899 -26.05059 1.000 32.67736 ? 2051 HOH A O    1 
HETATM 6052 O  O    . HOH S 6 .   ? -35.72075 -29.91760 -10.02177 1.000 26.47925 ? 2052 HOH A O    1 
HETATM 6053 O  O    . HOH S 6 .   ? -16.96798 5.95675   -17.66404 1.000 34.76182 ? 2053 HOH A O    1 
HETATM 6054 O  O    . HOH S 6 .   ? -2.95340  -14.69991 -28.55984 1.000 31.34825 ? 2054 HOH A O    1 
HETATM 6055 O  O    . HOH S 6 .   ? -4.19571  -13.76137 -6.93518  1.000 18.59146 ? 2055 HOH A O    1 
HETATM 6056 O  O    . HOH S 6 .   ? -17.65585 -16.70206 -36.61403 1.000 34.52758 ? 2056 HOH A O    1 
HETATM 6057 O  O    . HOH S 6 .   ? -11.97734 -41.87018 -10.60063 1.000 21.82606 ? 2057 HOH A O    1 
HETATM 6058 O  O    . HOH S 6 .   ? -22.87010 0.82641   -15.11787 1.000 27.56885 ? 2058 HOH A O    1 
HETATM 6059 O  O    . HOH S 6 .   ? -25.04892 0.06312   -8.02387  1.000 36.60678 ? 2059 HOH A O    1 
HETATM 6060 O  O    . HOH S 6 .   ? -11.60093 -37.83917 -3.88608  1.000 16.22012 ? 2060 HOH A O    1 
HETATM 6061 O  O    . HOH S 6 .   ? -22.04742 -30.80629 -26.94954 1.000 22.25242 ? 2061 HOH A O    1 
HETATM 6062 O  O    . HOH S 6 .   ? -3.17098  -24.13857 9.20932   1.000 36.56204 ? 2062 HOH A O    1 
HETATM 6063 O  O    . HOH S 6 .   ? -32.53292 -16.70139 -32.24661 1.000 36.87787 ? 2063 HOH A O    1 
HETATM 6064 O  O    . HOH S 6 .   ? -16.44812 -44.14387 -20.19833 1.000 20.72855 ? 2064 HOH A O    1 
HETATM 6065 O  O    . HOH S 6 .   ? -33.73461 -6.79453  -7.12920  1.000 40.61516 ? 2065 HOH A O    1 
HETATM 6066 O  O    . HOH S 6 .   ? -40.84060 -19.54540 -5.68100  1.000 32.42996 ? 2066 HOH A O    1 
HETATM 6067 O  O    . HOH S 6 .   ? -40.04835 -8.05122  -19.69803 1.000 23.26834 ? 2067 HOH A O    1 
HETATM 6068 O  O    . HOH S 6 .   ? -1.49288  -16.26698 -0.92234  1.000 24.10002 ? 2068 HOH A O    1 
HETATM 6069 O  O    . HOH S 6 .   ? -21.78115 -27.97170 10.53609  1.000 26.45030 ? 2069 HOH A O    1 
HETATM 6070 O  O    . HOH S 6 .   ? -9.62214  -6.92252  -26.18103 1.000 27.56885 ? 2070 HOH A O    1 
HETATM 6071 O  O    . HOH S 6 .   ? -23.68184 3.80013   -19.71040 1.000 38.25961 ? 2071 HOH A O    1 
HETATM 6072 O  O    . HOH S 6 .   ? -34.26061 -7.62049  -24.47154 1.000 20.15744 ? 2072 HOH A O    1 
HETATM 6073 O  O    . HOH S 6 .   ? -21.20137 4.42800   -0.98554  1.000 29.15062 ? 2073 HOH A O    1 
HETATM 6074 O  O    . HOH S 6 .   ? -9.70932  -9.68561  -26.39202 1.000 24.27372 ? 2074 HOH A O    1 
HETATM 6075 O  O    . HOH S 6 .   ? -32.49512 -11.62566 -6.54446  1.000 25.35806 ? 2075 HOH A O    1 
HETATM 6076 O  O    . HOH S 6 .   ? -12.01780 -20.74777 -14.06358 1.000 10.38256 ? 2076 HOH A O    1 
HETATM 6077 O  O    . HOH S 6 .   ? -2.74203  -17.34710 -5.45555  1.000 26.75034 ? 2077 HOH A O    1 
HETATM 6078 O  O    . HOH S 6 .   ? -7.16830  -29.59599 -16.08953 1.000 11.87222 ? 2078 HOH A O    1 
HETATM 6079 O  O    . HOH S 6 .   ? -38.13716 -24.27483 -26.28351 1.000 37.98062 ? 2079 HOH A O    1 
HETATM 6080 O  O    . HOH S 6 .   ? -8.11084  -3.27455  -25.94446 1.000 34.50916 ? 2080 HOH A O    1 
HETATM 6081 O  O    . HOH S 6 .   ? -12.27893 -48.17072 -20.07936 1.000 37.67006 ? 2081 HOH A O    1 
HETATM 6082 O  O    . HOH S 6 .   ? -13.62465 -16.47174 15.62414  1.000 39.73347 ? 2082 HOH A O    1 
HETATM 6083 O  O    . HOH S 6 .   ? -22.34635 2.54076   -17.82402 1.000 25.68442 ? 2083 HOH A O    1 
HETATM 6084 O  O    . HOH S 6 .   ? -29.63617 -33.67175 -15.32437 1.000 22.27084 ? 2084 HOH A O    1 
HETATM 6085 O  O    . HOH S 6 .   ? -43.38255 -21.27556 -4.72446  1.000 28.64004 ? 2085 HOH A O    1 
HETATM 6086 O  O    . HOH S 6 .   ? -6.12707  -29.48655 5.57300   1.000 24.85537 ? 2086 HOH A O    1 
HETATM 6087 O  O    . HOH S 6 .   ? -31.74221 -29.06995 -24.46796 1.000 26.04235 ? 2087 HOH A O    1 
HETATM 6088 O  O    . HOH S 6 .   ? -1.84982  -9.79736  -10.66782 1.000 17.46499 ? 2088 HOH A O    1 
HETATM 6089 O  O    . HOH S 6 .   ? -26.74492 -20.97598 -19.40669 1.000 11.32479 ? 2089 HOH A O    1 
HETATM 6090 O  O    . HOH S 6 .   ? -19.33735 3.16251   -6.81846  1.000 21.73920 ? 2090 HOH A O    1 
HETATM 6091 O  O    . HOH S 6 .   ? 1.80310   -33.60933 -1.31730  1.000 30.37182 ? 2091 HOH A O    1 
HETATM 6092 O  O    . HOH S 6 .   ? -20.59275 -9.21824  -26.37103 1.000 27.47674 ? 2092 HOH A O    1 
HETATM 6093 O  O    . HOH S 6 .   ? -32.80541 -30.14879 -16.64520 1.000 25.88181 ? 2093 HOH A O    1 
HETATM 6094 O  O    . HOH S 6 .   ? -7.18348  -10.41604 -26.28026 1.000 22.65774 ? 2094 HOH A O    1 
HETATM 6095 O  O    . HOH S 6 .   ? -27.86887 1.03681   -20.02177 1.000 25.18962 ? 2095 HOH A O    1 
HETATM 6096 O  O    . HOH S 6 .   ? -26.50040 -7.08645  -24.84717 1.000 30.60343 ? 2096 HOH A O    1 
HETATM 6097 O  O    . HOH S 6 .   ? -28.89374 -30.37710 4.11288   1.000 25.80548 ? 2097 HOH A O    1 
HETATM 6098 O  O    . HOH S 6 .   ? -22.43230 -19.40929 -19.60616 1.000 10.95633 ? 2098 HOH A O    1 
HETATM 6099 O  O    . HOH S 6 .   ? -17.27783 -9.57406  -7.13140  1.000 10.26151 ? 2099 HOH A O    1 
HETATM 6100 O  O    . HOH S 6 .   ? -18.40570 -24.28287 -20.66781 1.000 11.74326 ? 2100 HOH A O    1 
HETATM 6101 O  O    . HOH S 6 .   ? -8.18113  -44.52852 -17.01952 1.000 30.74818 ? 2101 HOH A O    1 
HETATM 6102 O  O    . HOH S 6 .   ? -37.43640 -23.57081 -19.33640 1.000 16.99126 ? 2102 HOH A O    1 
HETATM 6103 O  O    . HOH S 6 .   ? -2.57518  -13.55380 -15.47109 1.000 18.23878 ? 2103 HOH A O    1 
HETATM 6104 O  O    . HOH S 6 .   ? -25.11636 -29.47399 -22.70521 1.000 14.64888 ? 2104 HOH A O    1 
HETATM 6105 O  O    . HOH S 6 .   ? 0.58103   -3.09030  -0.81650  1.000 27.93732 ? 2105 HOH A O    1 
HETATM 6106 O  O    . HOH S 6 .   ? -19.67499 1.60262   -4.67405  1.000 21.62077 ? 2106 HOH A O    1 
HETATM 6107 O  O    . HOH S 6 .   ? -41.97283 -11.58379 -8.87997  1.000 26.34239 ? 2107 HOH A O    1 
HETATM 6108 O  O    . HOH S 6 .   ? -25.15868 -31.76538 -24.16967 1.000 19.39682 ? 2108 HOH A O    1 
HETATM 6109 O  O    . HOH S 6 .   ? -15.12803 -11.47793 15.17902  1.000 39.67294 ? 2109 HOH A O    1 
HETATM 6110 O  O    . HOH S 6 .   ? -29.02608 -4.71244  -14.51606 1.000 26.22395 ? 2110 HOH A O    1 
HETATM 6111 O  O    . HOH S 6 .   ? -37.43407 -25.14798 -21.59186 1.000 20.31008 ? 2111 HOH A O    1 
HETATM 6112 O  O    . HOH S 6 .   ? -9.78857  -8.28657  15.51092  1.000 25.94234 ? 2112 HOH A O    1 
HETATM 6113 O  O    . HOH S 6 .   ? 4.82968   -5.08884  -6.33437  1.000 32.83001 ? 2113 HOH A O    1 
HETATM 6114 O  O    . HOH S 6 .   ? -2.31562  -10.83299 -13.11273 1.000 18.07297 ? 2114 HOH A O    1 
HETATM 6115 O  O    . HOH S 6 .   ? -18.80809 -44.14537 -9.44528  1.000 20.01795 ? 2115 HOH A O    1 
HETATM 6116 O  O    . HOH S 6 .   ? -37.08388 -14.78489 -21.49901 1.000 20.97069 ? 2116 HOH A O    1 
HETATM 6117 O  O    . HOH S 6 .   ? -22.87773 -27.76691 -23.42930 1.000 19.86267 ? 2117 HOH A O    1 
HETATM 6118 O  O    . HOH S 6 .   ? -2.92375  -7.09940  10.54271  1.000 25.97919 ? 2118 HOH A O    1 
HETATM 6119 O  O    . HOH S 6 .   ? -29.82861 -24.64093 -18.97544 1.000 13.50137 ? 2119 HOH A O    1 
HETATM 6120 O  O    . HOH S 6 .   ? 0.42806   -6.53569  8.20633   1.000 27.01089 ? 2120 HOH A O    1 
HETATM 6121 O  O    . HOH S 6 .   ? -4.66394  -26.71238 6.72002   1.000 22.09715 ? 2121 HOH A O    1 
HETATM 6122 O  O    . HOH S 6 .   ? -5.39926  -31.46731 -19.57890 1.000 13.99353 ? 2122 HOH A O    1 
HETATM 6123 O  O    . HOH S 6 .   ? -2.74911  -33.50258 -1.09597  1.000 22.79986 ? 2123 HOH A O    1 
HETATM 6124 O  O    . HOH S 6 .   ? -38.91287 -25.02435 -7.92003  1.000 22.19189 ? 2124 HOH A O    1 
HETATM 6125 O  O    . HOH S 6 .   ? -39.54824 -17.10668 -6.35327  1.000 21.99187 ? 2125 HOH A O    1 
HETATM 6126 O  O    . HOH S 6 .   ? -0.60198  -7.13449  -0.59448  1.000 17.12812 ? 2126 HOH A O    1 
HETATM 6127 O  O    . HOH S 6 .   ? -27.48597 -35.09559 -0.94709  1.000 27.63728 ? 2127 HOH A O    1 
HETATM 6128 O  O    . HOH S 6 .   ? -18.51011 -14.44354 3.79943   1.000 13.72245 ? 2128 HOH A O    1 
HETATM 6129 O  O    . HOH S 6 .   ? -24.96064 -35.74313 -6.63506  1.000 15.57267 ? 2129 HOH A O    1 
HETATM 6130 O  O    . HOH S 6 .   ? -18.98285 -5.93907  5.93516   1.000 26.62663 ? 2130 HOH A O    1 
HETATM 6131 O  O    . HOH S 6 .   ? -21.09951 -27.63408 -26.68546 1.000 29.42961 ? 2131 HOH A O    1 
HETATM 6132 O  O    . HOH S 6 .   ? -6.68504  -20.42193 9.95286   1.000 21.81027 ? 2132 HOH A O    1 
HETATM 6133 O  O    . HOH S 6 .   ? -2.41168  -10.01801 -19.42227 1.000 29.63226 ? 2133 HOH A O    1 
HETATM 6134 O  O    . HOH S 6 .   ? -32.37252 -9.90302  -25.72529 1.000 22.21558 ? 2134 HOH A O    1 
HETATM 6135 O  O    . HOH S 6 .   ? -3.04525  -27.53932 0.47149   1.000 21.34705 ? 2135 HOH A O    1 
HETATM 6136 O  O    . HOH S 6 .   ? -18.30606 -11.44777 -14.12992 1.000 9.64037  ? 2136 HOH A O    1 
HETATM 6137 O  O    . HOH S 6 .   ? -20.36200 1.34917   -11.90683 1.000 21.74710 ? 2137 HOH A O    1 
HETATM 6138 O  O    . HOH S 6 .   ? -19.71005 -45.75584 -19.53936 1.000 37.67796 ? 2138 HOH A O    1 
HETATM 6139 O  O    . HOH S 6 .   ? -5.24686  -11.91694 -28.91188 1.000 23.61311 ? 2139 HOH A O    1 
HETATM 6140 O  O    . HOH S 6 .   ? 2.53155   -0.49559  -4.75657  1.000 33.08004 ? 2140 HOH A O    1 
HETATM 6141 O  O    . HOH S 6 .   ? 6.00619   -27.60402 3.73391   1.000 38.43068 ? 2141 HOH A O    1 
HETATM 6142 O  O    . HOH S 6 .   ? -29.46422 -8.01686  -13.78557 1.000 14.23303 ? 2142 HOH A O    1 
HETATM 6143 O  O    . HOH S 6 .   ? -21.16209 -42.99955 -5.73417  1.000 25.46334 ? 2143 HOH A O    1 
HETATM 6144 O  O    . HOH S 6 .   ? -21.57390 -25.52018 -4.34138  1.000 11.12477 ? 2144 HOH A O    1 
HETATM 6145 O  O    . HOH S 6 .   ? -26.04890 -23.03249 -2.86635  1.000 11.83011 ? 2145 HOH A O    1 
HETATM 6146 O  O    . HOH S 6 .   ? -26.06097 -1.70117  -14.07173 1.000 22.27085 ? 2146 HOH A O    1 
HETATM 6147 O  O    . HOH S 6 .   ? -34.82558 -17.54319 -21.41112 1.000 28.10312 ? 2147 HOH A O    1 
HETATM 6148 O  O    . HOH S 6 .   ? -14.03594 -12.43195 11.35705  1.000 15.72796 ? 2148 HOH A O    1 
HETATM 6149 O  O    . HOH S 6 .   ? -13.47352 -31.42819 7.80563   1.000 24.72378 ? 2149 HOH A O    1 
HETATM 6150 O  O    . HOH S 6 .   ? -33.98761 -8.12264  -12.84101 1.000 36.43044 ? 2150 HOH A O    1 
HETATM 6151 O  O    . HOH S 6 .   ? -19.09892 0.73531   -14.20612 1.000 13.24344 ? 2151 HOH A O    1 
HETATM 6152 O  O    . HOH S 6 .   ? -2.43301  -33.41384 -18.57169 1.000 21.78658 ? 2152 HOH A O    1 
HETATM 6153 O  O    . HOH S 6 .   ? 0.55517   -19.81377 -2.54669  1.000 19.88898 ? 2153 HOH A O    1 
HETATM 6154 O  O    . HOH S 6 .   ? -5.10532  -28.80238 -14.38902 1.000 12.55124 ? 2154 HOH A O    1 
HETATM 6155 O  O    . HOH S 6 .   ? -9.17289  -9.77911  -34.46198 1.000 36.63047 ? 2155 HOH A O    1 
HETATM 6156 O  O    . HOH S 6 .   ? -15.78814 -41.29690 -0.55813  1.000 21.81553 ? 2156 HOH A O    1 
HETATM 6157 O  O    . HOH S 6 .   ? -2.17088  -16.00386 8.18368   1.000 25.43965 ? 2157 HOH A O    1 
HETATM 6158 O  O    . HOH S 6 .   ? -33.93869 -4.21626  -21.92572 1.000 22.34717 ? 2158 HOH A O    1 
HETATM 6159 O  O    . HOH S 6 .   ? -22.65551 -4.95264  -13.87877 1.000 15.27264 ? 2159 HOH A O    1 
HETATM 6160 O  O    . HOH S 6 .   ? 1.20713   -6.25964  -11.80438 1.000 28.90323 ? 2160 HOH A O    1 
HETATM 6161 O  O    . HOH S 6 .   ? 2.81351   -21.18597 -2.03371  1.000 21.03123 ? 2161 HOH A O    1 
HETATM 6162 O  O    . HOH S 6 .   ? -9.33448  -32.11695 0.36178   1.000 19.46261 ? 2162 HOH A O    1 
HETATM 6163 O  O    . HOH S 6 .   ? -23.08474 -11.69071 10.50847  1.000 37.37530 ? 2163 HOH A O    1 
HETATM 6164 O  O    . HOH S 6 .   ? -5.02467  -28.10667 -30.44976 1.000 39.35974 ? 2164 HOH A O    1 
HETATM 6165 O  O    . HOH S 6 .   ? -35.86631 -10.89591 -5.94720  1.000 33.54852 ? 2165 HOH A O    1 
HETATM 6166 O  O    . HOH S 6 .   ? -23.49182 -18.90167 -15.07174 1.000 10.95105 ? 2166 HOH A O    1 
HETATM 6167 O  O    . HOH S 6 .   ? 1.73246   -20.12219 5.15906   1.000 31.87990 ? 2167 HOH A O    1 
HETATM 6168 O  O    . HOH S 6 .   ? -7.36751  1.98834   -14.71434 1.000 18.17825 ? 2168 HOH A O    1 
HETATM 6169 O  O    . HOH S 6 .   ? -21.48491 -28.00579 -3.39406  1.000 15.54899 ? 2169 HOH A O    1 
HETATM 6170 O  O    . HOH S 6 .   ? -18.92337 -13.17851 -29.78215 1.000 22.21032 ? 2170 HOH A O    1 
HETATM 6171 O  O    . HOH S 6 .   ? -15.91478 -21.73523 -33.05099 1.000 20.62855 ? 2171 HOH A O    1 
HETATM 6172 O  O    . HOH S 6 .   ? 2.26563   -8.39645  -6.88249  1.000 26.91877 ? 2172 HOH A O    1 
HETATM 6173 O  O    . HOH S 6 .   ? -7.18373  -40.74743 -5.94890  1.000 40.80728 ? 2173 HOH A O    1 
HETATM 6174 O  O    . HOH S 6 .   ? -1.74253  -28.49223 -19.62821 1.000 24.12634 ? 2174 HOH A O    1 
HETATM 6175 O  O    . HOH S 6 .   ? -23.83029 -37.12253 -3.49227  1.000 17.81505 ? 2175 HOH A O    1 
HETATM 6176 O  O    . HOH S 6 .   ? -28.02618 -37.42125 -7.59433  1.000 32.95371 ? 2176 HOH A O    1 
HETATM 6177 O  O    . HOH S 6 .   ? -3.41871  -37.61408 -23.48411 1.000 31.94043 ? 2177 HOH A O    1 
HETATM 6178 O  O    . HOH S 6 .   ? -28.43979 -35.71821 -10.71853 1.000 19.71791 ? 2178 HOH A O    1 
HETATM 6179 O  O    . HOH S 6 .   ? -27.89329 -21.19593 -35.43156 1.000 34.86184 ? 2179 HOH A O    1 
HETATM 6180 O  O    . HOH S 6 .   ? -18.40425 -40.60441 -0.91957  1.000 16.34119 ? 2180 HOH A O    1 
HETATM 6181 O  O    . HOH S 6 .   ? -30.52232 -19.77994 -12.16587 1.000 11.25373 ? 2181 HOH A O    1 
HETATM 6182 O  O    . HOH S 6 .   ? -10.88558 -39.76183 -0.74496  1.000 30.00600 ? 2182 HOH A O    1 
HETATM 6183 O  O    . HOH S 6 .   ? -23.45282 -7.47980  -18.18612 1.000 12.59600 ? 2183 HOH A O    1 
HETATM 6184 O  O    . HOH S 6 .   ? -7.64016  -22.69789 13.31661  1.000 26.25290 ? 2184 HOH A O    1 
HETATM 6185 O  O    . HOH S 6 .   ? -3.74024  -7.80628  -2.77020  1.000 15.70164 ? 2185 HOH A O    1 
HETATM 6186 O  O    . HOH S 6 .   ? -9.67725  -43.43929 -14.37766 1.000 21.38916 ? 2186 HOH A O    1 
HETATM 6187 O  O    . HOH S 6 .   ? -7.44036  2.79342   -18.66358 1.000 30.12706 ? 2187 HOH A O    1 
HETATM 6188 O  O    . HOH S 6 .   ? -34.29905 -29.54181 -2.24889  1.000 28.03996 ? 2188 HOH A O    1 
HETATM 6189 O  O    . HOH S 6 .   ? 3.21823   -29.60528 -2.19896  1.000 40.71780 ? 2189 HOH A O    1 
HETATM 6190 O  O    . HOH S 6 .   ? -2.12871  -13.19758 7.16261   1.000 28.88743 ? 2190 HOH A O    1 
HETATM 6191 O  O    . HOH S 6 .   ? -13.72406 -17.88561 -7.80003  1.000 10.41415 ? 2191 HOH A O    1 
HETATM 6192 O  O    . HOH S 6 .   ? -4.41428  -30.64954 0.64706   1.000 34.52495 ? 2192 HOH A O    1 
HETATM 6193 O  O    . HOH S 6 .   ? -36.79684 -6.88448  -16.91935 1.000 23.91841 ? 2193 HOH A O    1 
HETATM 6194 O  O    . HOH S 6 .   ? -17.89726 -25.72843 -1.00317  1.000 11.98014 ? 2194 HOH A O    1 
HETATM 6195 O  O    . HOH S 6 .   ? -11.19595 -29.57449 -1.98186  1.000 14.04881 ? 2195 HOH A O    1 
HETATM 6196 O  O    . HOH S 6 .   ? -23.44853 -2.29408  -14.04919 1.000 19.00466 ? 2196 HOH A O    1 
HETATM 6197 O  O    . HOH S 6 .   ? -43.07944 -18.99626 -10.56345 1.000 20.90225 ? 2197 HOH A O    1 
HETATM 6198 O  O    . HOH S 6 .   ? -6.77811  -5.38700  -22.77752 1.000 22.75511 ? 2198 HOH A O    1 
HETATM 6199 O  O    . HOH S 6 .   ? -4.40648  -30.75932 8.80351   1.000 39.94665 ? 2199 HOH A O    1 
HETATM 6200 O  O    . HOH S 6 .   ? -12.57476 -30.97461 0.21206   1.000 27.22670 ? 2200 HOH A O    1 
HETATM 6201 O  O    . HOH S 6 .   ? -29.42458 -12.01871 -25.90715 1.000 23.66575 ? 2201 HOH A O    1 
HETATM 6202 O  O    . HOH S 6 .   ? -16.47607 -15.56563 -19.02535 1.000 26.11868 ? 2202 HOH A O    1 
HETATM 6203 O  O    . HOH S 6 .   ? -4.40107  -36.92168 -12.81986 1.000 26.87930 ? 2203 HOH A O    1 
HETATM 6204 O  O    . HOH S 6 .   ? -9.78531  -26.26249 11.25512  1.000 28.59529 ? 2204 HOH A O    1 
HETATM 6205 O  O    . HOH S 6 .   ? 1.25554   -30.02905 -9.03042  1.000 28.63477 ? 2205 HOH A O    1 
HETATM 6206 O  O    . HOH S 6 .   ? -22.67373 -25.14131 8.56449   1.000 19.23101 ? 2206 HOH A O    1 
HETATM 6207 O  O    . HOH S 6 .   ? -25.35136 -25.42869 -17.45640 1.000 10.88000 ? 2207 HOH A O    1 
HETATM 6208 O  O    . HOH S 6 .   ? 1.85076   -30.54765 -4.12783  1.000 29.21115 ? 2208 HOH A O    1 
HETATM 6209 O  O    . HOH S 6 .   ? -15.20410 -14.79032 12.01533  1.000 16.87546 ? 2209 HOH A O    1 
HETATM 6210 O  O    . HOH S 6 .   ? -22.79476 -43.89590 -8.89704  1.000 28.04523 ? 2210 HOH A O    1 
HETATM 6211 O  O    . HOH S 6 .   ? -2.41100  -2.12964  -15.46544 1.000 17.59923 ? 2211 HOH A O    1 
HETATM 6212 O  O    B HOH S 6 .   ? -21.82601 -15.41032 -7.04929  0.865 26.59242 ? 2212 HOH A O    1 
HETATM 6213 O  O    . HOH S 6 .   ? -8.95601  -37.48494 -4.44041  1.000 17.93348 ? 2213 HOH A O    1 
HETATM 6214 O  O    . HOH S 6 .   ? -13.18143 -44.90487 -21.73799 1.000 21.70762 ? 2214 HOH A O    1 
HETATM 6215 O  O    . HOH S 6 .   ? -3.34578  -9.19289  -15.96246 1.000 24.33162 ? 2215 HOH A O    1 
HETATM 6216 O  O    . HOH S 6 .   ? -20.91604 -6.25871  -17.94064 1.000 12.14067 ? 2216 HOH A O    1 
HETATM 6217 O  O    . HOH S 6 .   ? 4.37388   -20.66162 3.00139   1.000 28.07681 ? 2217 HOH A O    1 
HETATM 6218 O  O    . HOH S 6 .   ? 1.17211   -4.45856  1.67811   1.000 23.41835 ? 2218 HOH A O    1 
HETATM 6219 O  O    . HOH S 6 .   ? -9.43090  -19.67220 10.30438  1.000 17.82558 ? 2219 HOH A O    1 
HETATM 6220 O  O    . HOH S 6 .   ? -32.54988 -27.73394 2.59398   1.000 43.10492 ? 2220 HOH A O    1 
HETATM 6221 O  O    . HOH S 6 .   ? -33.70643 -20.91435 -29.16957 1.000 24.38689 ? 2221 HOH A O    1 
HETATM 6222 O  O    . HOH S 6 .   ? -0.14619  -7.50991  -10.30508 1.000 32.33258 ? 2222 HOH A O    1 
HETATM 6223 O  O    . HOH S 6 .   ? -2.17746  2.79767   -11.09259 1.000 15.97272 ? 2223 HOH A O    1 
HETATM 6224 O  O    . HOH S 6 .   ? -3.93530  -11.02538 -22.37563 1.000 25.80548 ? 2224 HOH A O    1 
HETATM 6225 O  O    . HOH S 6 .   ? -18.15505 -7.65514  -9.14462  1.000 13.97511 ? 2225 HOH A O    1 
HETATM 6226 O  O    . HOH S 6 .   ? -3.70128  -13.81679 -22.77345 1.000 21.12334 ? 2226 HOH A O    1 
HETATM 6227 O  O    . HOH S 6 .   ? -0.48325  -12.37851 5.33246   1.000 36.57782 ? 2227 HOH A O    1 
HETATM 6228 O  O    . HOH S 6 .   ? -20.76407 -2.13660  -3.32070  1.000 22.24453 ? 2228 HOH A O    1 
HETATM 6229 O  O    . HOH S 6 .   ? -2.80314  -11.83917 -26.19722 1.000 30.13232 ? 2229 HOH A O    1 
HETATM 6230 O  O    . HOH S 6 .   ? -13.59872 -20.55594 -32.58149 1.000 25.88707 ? 2230 HOH A O    1 
HETATM 6231 O  O    . HOH S 6 .   ? -14.67487 -26.18550 12.31936  1.000 27.20565 ? 2231 HOH A O    1 
HETATM 6232 O  O    . HOH S 6 .   ? -21.70390 -32.52995 9.02808   1.000 25.93708 ? 2232 HOH A O    1 
HETATM 6233 O  O    . HOH S 6 .   ? 0.52962   -27.35517 -19.25874 1.000 20.63644 ? 2233 HOH A O    1 
HETATM 6234 O  O    . HOH S 6 .   ? -15.45609 -6.39948  -8.75546  1.000 26.75559 ? 2234 HOH A O    1 
HETATM 6235 O  O    . HOH S 6 .   ? -6.23304  -3.25972  -20.52407 1.000 23.14726 ? 2235 HOH A O    1 
HETATM 6236 O  O    . HOH S 6 .   ? -20.21539 -10.19213 -32.03257 1.000 42.72857 ? 2236 HOH A O    1 
HETATM 6237 O  O    . HOH S 6 .   ? -21.37441 -13.62456 -29.66127 1.000 29.55857 ? 2237 HOH A O    1 
HETATM 6238 O  O    . HOH S 6 .   ? -12.28804 -7.75431  -28.47379 1.000 29.52698 ? 2238 HOH A O    1 
HETATM 6239 O  O    . HOH S 6 .   ? -31.89793 -30.64246 -1.19253  1.000 20.72855 ? 2239 HOH A O    1 
HETATM 6240 O  O    . HOH S 6 .   ? -28.23293 -21.82254 0.15672   1.000 29.11114 ? 2240 HOH A O    1 
HETATM 6241 O  O    . HOH S 6 .   ? -45.27243 -11.52145 -2.83163  1.000 38.10959 ? 2241 HOH A O    1 
HETATM 6242 O  O    . HOH S 6 .   ? -2.85199  -4.68719  9.31710   1.000 20.38114 ? 2242 HOH A O    1 
HETATM 6243 O  O    . HOH S 6 .   ? -23.26992 -17.64612 -17.51317 1.000 12.19595 ? 2243 HOH A O    1 
HETATM 6244 O  O    . HOH S 6 .   ? -14.26793 -42.25772 -27.90789 1.000 26.36607 ? 2244 HOH A O    1 
HETATM 6245 O  O    . HOH S 6 .   ? -7.82667  -31.72705 6.82615   1.000 45.81051 ? 2245 HOH A O    1 
HETATM 6246 O  O    . HOH S 6 .   ? -7.26747  -23.46072 0.61358   1.000 12.84076 ? 2246 HOH A O    1 
HETATM 6247 O  O    . HOH S 6 .   ? -4.05612  -18.82469 -30.14856 1.000 17.25446 ? 2247 HOH A O    1 
HETATM 6248 O  O    . HOH S 6 .   ? -8.07052  -7.52532  13.39929  1.000 30.03757 ? 2248 HOH A O    1 
HETATM 6249 O  O    . HOH S 6 .   ? -1.11570  -37.10383 -19.22745 1.000 23.23939 ? 2249 HOH A O    1 
HETATM 6250 O  O    . HOH S 6 .   ? -43.34311 -17.75201 -5.68653  1.000 26.53715 ? 2250 HOH A O    1 
HETATM 6251 O  O    . HOH S 6 .   ? -34.30774 -20.59390 -3.35722  1.000 26.09499 ? 2251 HOH A O    1 
HETATM 6252 O  O    . HOH S 6 .   ? -17.94144 -37.33288 -31.77881 1.000 31.69566 ? 2252 HOH A O    1 
HETATM 6253 O  O    . HOH S 6 .   ? -24.01003 -11.63946 -27.05753 1.000 29.29011 ? 2253 HOH A O    1 
HETATM 6254 O  O    . HOH S 6 .   ? -24.83372 -16.40182 -12.03709 1.000 10.96422 ? 2254 HOH A O    1 
HETATM 6255 O  O    . HOH S 6 .   ? -16.08857 -3.84475  14.09342  1.000 21.65498 ? 2255 HOH A O    1 
HETATM 6256 O  O    . HOH S 6 .   ? -20.44796 -23.36823 12.42165  1.000 40.01245 ? 2256 HOH A O    1 
HETATM 6257 O  O    . HOH S 6 .   ? -3.09917  -16.93672 -2.98776  1.000 22.76301 ? 2257 HOH A O    1 
HETATM 6258 O  O    . HOH S 6 .   ? -38.65917 -12.90042 -15.40612 1.000 20.40483 ? 2258 HOH A O    1 
HETATM 6259 O  O    . HOH S 6 .   ? -13.00573 -36.59881 3.13535   1.000 49.73467 ? 2259 HOH A O    1 
HETATM 6260 O  O    . HOH S 6 .   ? -3.56190  -34.81407 -20.85877 1.000 20.86278 ? 2260 HOH A O    1 
HETATM 6261 O  O    . HOH S 6 .   ? -17.41056 -15.54056 -12.10984 1.000 13.34346 ? 2261 HOH A O    1 
HETATM 6262 O  O    . HOH S 6 .   ? -22.93008 -0.18037  -11.93623 1.000 21.48391 ? 2262 HOH A O    1 
HETATM 6263 O  O    . HOH S 6 .   ? -22.74039 -25.73313 -38.79496 1.000 36.54361 ? 2263 HOH A O    1 
HETATM 6264 O  O    . HOH S 6 .   ? -15.14250 -36.38683 4.58577   1.000 25.59230 ? 2264 HOH A O    1 
HETATM 6265 O  O    . HOH S 6 .   ? -27.10439 -36.50437 -13.04690 1.000 21.30231 ? 2265 HOH A O    1 
HETATM 6266 O  O    . HOH S 6 .   ? -4.84776  -30.85013 -16.89426 1.000 12.56441 ? 2266 HOH A O    1 
HETATM 6267 O  O    . HOH S 6 .   ? -35.74742 -24.18286 -27.29368 1.000 24.23687 ? 2267 HOH A O    1 
HETATM 6268 O  O    . HOH S 6 .   ? -27.17090 -14.23551 -31.52526 1.000 29.96388 ? 2268 HOH A O    1 
HETATM 6269 O  O    . HOH S 6 .   ? -10.27989 -32.20648 5.26313   1.000 38.31488 ? 2269 HOH A O    1 
HETATM 6270 O  O    . HOH S 6 .   ? -29.70396 -24.83253 -33.35050 1.000 27.47674 ? 2270 HOH A O    1 
HETATM 6271 O  O    . HOH S 6 .   ? -1.20340  -26.23469 2.01014   1.000 22.94461 ? 2271 HOH A O    1 
HETATM 6272 O  O    . HOH S 6 .   ? -6.92945  -17.69407 -32.19825 1.000 21.07334 ? 2272 HOH A O    1 
HETATM 6273 O  O    . HOH S 6 .   ? -24.24156 -40.69920 -6.10390  1.000 30.89557 ? 2273 HOH A O    1 
HETATM 6274 O  O    . HOH S 6 .   ? -26.00096 -38.44180 -20.56489 1.000 18.73884 ? 2274 HOH A O    1 
HETATM 6275 O  O    . HOH S 6 .   ? -9.12461  -15.78427 -33.08601 1.000 24.82905 ? 2275 HOH A O    1 
HETATM 6276 O  O    . HOH S 6 .   ? 0.03607   -18.30843 7.43611   1.000 31.70619 ? 2276 HOH A O    1 
HETATM 6277 O  O    . HOH S 6 .   ? -6.69692  -43.14818 -14.77373 1.000 42.82331 ? 2277 HOH A O    1 
HETATM 6278 O  O    . HOH S 6 .   ? -26.55910 0.13195   -22.13486 1.000 27.55043 ? 2278 HOH A O    1 
HETATM 6279 O  O    . HOH S 6 .   ? -37.17494 -25.20260 -14.20698 1.000 23.55784 ? 2279 HOH A O    1 
HETATM 6280 O  O    . HOH S 6 .   ? -5.89032  -29.85772 -32.11815 1.000 26.15552 ? 2280 HOH A O    1 
HETATM 6281 O  O    . HOH S 6 .   ? -39.59957 -24.82536 -12.45536 1.000 18.84412 ? 2281 HOH A O    1 
HETATM 6282 O  O    . HOH S 6 .   ? -24.00898 -24.12381 -4.41950  1.000 11.16951 ? 2282 HOH A O    1 
HETATM 6283 O  O    . HOH S 6 .   ? -0.42220  -13.71808 -0.79364  1.000 16.60964 ? 2283 HOH A O    1 
HETATM 6284 O  O    . HOH S 6 .   ? -37.05047 -31.52432 -20.61123 1.000 41.50210 ? 2284 HOH A O    1 
HETATM 6285 O  O    . HOH S 6 .   ? -20.73062 -15.49070 -28.31166 1.000 26.50294 ? 2285 HOH A O    1 
HETATM 6286 O  O    . HOH S 6 .   ? -25.04621 -19.91017 -35.17005 1.000 30.25602 ? 2286 HOH A O    1 
HETATM 6287 O  O    . HOH S 6 .   ? -12.90817 -35.07343 6.38785   1.000 48.46873 ? 2287 HOH A O    1 
HETATM 6288 O  O    . HOH S 6 .   ? -7.31147  -41.72643 -12.55422 1.000 28.35315 ? 2288 HOH A O    1 
HETATM 6289 O  O    . HOH S 6 .   ? -10.95404 -18.20849 16.75281  1.000 46.42374 ? 2289 HOH A O    1 
HETATM 6290 O  O    . HOH S 6 .   ? -9.93414  -17.53292 8.53495   1.000 16.83335 ? 2290 HOH A O    1 
HETATM 6291 O  O    . HOH S 6 .   ? -15.67830 -42.10695 -5.32902  1.000 26.78981 ? 2291 HOH A O    1 
HETATM 6292 O  O    . HOH S 6 .   ? -7.65034  -42.70830 -9.84587  1.000 37.98589 ? 2292 HOH A O    1 
HETATM 6293 O  O    . HOH S 6 .   ? -5.23557  -41.38699 -16.22261 1.000 33.53536 ? 2293 HOH A O    1 
HETATM 6294 O  O    . HOH S 6 .   ? -3.08167  -38.77399 -9.03761  1.000 34.35915 ? 2294 HOH A O    1 
HETATM 6295 O  O    . HOH S 6 .   ? -34.14449 -32.91047 -4.81710  1.000 38.39910 ? 2295 HOH A O    1 
HETATM 6296 O  O    . HOH S 6 .   ? -3.81930  -38.79426 -26.66147 1.000 34.77761 ? 2296 HOH A O    1 
HETATM 6297 O  O    . HOH S 6 .   ? -21.49712 -3.72370  -25.48599 1.000 34.76972 ? 2297 HOH A O    1 
HETATM 6298 O  O    . HOH S 6 .   ? -23.18529 -3.20683  -5.67848  1.000 35.41980 ? 2298 HOH A O    1 
HETATM 6299 O  O    . HOH S 6 .   ? -30.30234 -34.99922 -19.79821 1.000 40.69411 ? 2299 HOH A O    1 
HETATM 6300 O  O    . HOH S 6 .   ? -28.56575 -32.54896 0.34833   1.000 27.47410 ? 2300 HOH A O    1 
HETATM 6301 O  O    . HOH S 6 .   ? -24.42401 -5.15573  -0.96667  1.000 30.26391 ? 2301 HOH A O    1 
HETATM 6302 O  O    . HOH S 6 .   ? -15.36790 -14.38308 14.82028  1.000 32.43522 ? 2302 HOH A O    1 
HETATM 6303 O  O    . HOH S 6 .   ? -0.77623  -15.40142 -4.19742  1.000 37.90430 ? 2303 HOH A O    1 
HETATM 6304 O  O    . HOH S 6 .   ? -38.69313 -25.05133 -17.27270 1.000 32.41944 ? 2304 HOH A O    1 
HETATM 6305 O  O    . HOH S 6 .   ? 3.11769   -31.37331 -0.24058  1.000 39.81769 ? 2305 HOH A O    1 
HETATM 6306 O  O    . HOH S 6 .   ? -4.51094  -12.11634 -17.60056 1.000 37.80955 ? 2306 HOH A O    1 
HETATM 6307 O  O    . HOH S 6 .   ? -12.54678 -20.46673 -35.35966 1.000 33.76433 ? 2307 HOH A O    1 
HETATM 6308 O  O    . HOH S 6 .   ? -13.31769 -41.79429 -7.60425  1.000 24.82115 ? 2308 HOH A O    1 
HETATM 6309 O  O    . HOH S 6 .   ? -14.92658 -3.30832  -26.57810 1.000 33.37744 ? 2309 HOH A O    1 
HETATM 6310 O  O    . HOH S 6 .   ? -4.40447  0.36094   -21.56526 1.000 37.76744 ? 2310 HOH A O    1 
HETATM 6311 O  O    . HOH S 6 .   ? -22.10771 -32.31378 -29.85654 1.000 40.00719 ? 2311 HOH A O    1 
HETATM 6312 O  O    . HOH S 6 .   ? -14.85632 -7.31001  -28.74763 1.000 27.36883 ? 2312 HOH A O    1 
HETATM 6313 O  O    . HOH S 6 .   ? -12.15276 0.95136   -20.58365 1.000 31.16139 ? 2313 HOH A O    1 
HETATM 6314 O  O    . HOH S 6 .   ? 4.96699   0.77110   -5.09722  1.000 36.54625 ? 2314 HOH A O    1 
HETATM 6315 O  O    . HOH S 6 .   ? -27.52740 -25.16875 -1.78564  1.000 15.54635 ? 2315 HOH A O    1 
HETATM 6316 O  O    . HOH S 6 .   ? -2.96472  -13.97348 -18.87855 1.000 26.68979 ? 2316 HOH A O    1 
HETATM 6317 O  O    . HOH S 6 .   ? -32.77156 -34.30764 -6.16386  1.000 35.56192 ? 2317 HOH A O    1 
HETATM 6318 O  O    . HOH S 6 .   ? 3.18008   2.41750   -11.14436 1.000 31.91148 ? 2318 HOH A O    1 
HETATM 6319 O  O    . HOH S 6 .   ? -16.57606 -5.68289  -27.72674 1.000 41.30471 ? 2319 HOH A O    1 
HETATM 6320 O  O    . HOH S 6 .   ? 1.83859   5.06640   -9.62791  1.000 34.43810 ? 2320 HOH A O    1 
HETATM 6321 O  O    . HOH S 6 .   ? -9.69513  0.97050   -20.69819 1.000 33.85908 ? 2321 HOH A O    1 
HETATM 6322 O  O    . HOH S 6 .   ? -4.98816  -13.88846 -32.72770 1.000 37.41740 ? 2322 HOH A O    1 
HETATM 6323 O  O    . HOH S 6 .   ? -35.74815 -15.80885 -23.76220 1.000 28.64530 ? 2323 HOH A O    1 
HETATM 6324 O  O    . HOH S 6 .   ? -23.88945 -18.52810 -36.57884 1.000 35.59876 ? 2324 HOH A O    1 
HETATM 6325 O  O    . HOH S 6 .   ? -14.93469 -29.57643 -37.96982 1.000 40.30986 ? 2325 HOH A O    1 
HETATM 6326 O  O    . HOH S 6 .   ? -30.24474 -8.11759  -11.02981 1.000 21.04965 ? 2326 HOH A O    1 
HETATM 6327 O  O    . HOH S 6 .   ? -0.96745  -17.90286 -6.69198  1.000 27.77677 ? 2327 HOH A O    1 
HETATM 6328 O  O    . HOH S 6 .   ? -19.93947 2.03111   -17.58289 1.000 40.86782 ? 2328 HOH A O    1 
HETATM 6329 O  O    . HOH S 6 .   ? -20.95740 -4.19880  12.54174  1.000 37.11210 ? 2329 HOH A O    1 
HETATM 6330 O  O    . HOH S 6 .   ? -14.68446 -43.10927 0.38376   1.000 38.56754 ? 2330 HOH A O    1 
HETATM 6331 O  O    . HOH S 6 .   ? -27.35725 -11.02036 5.42530   1.000 39.88875 ? 2331 HOH A O    1 
HETATM 6332 O  O    . HOH S 6 .   ? -29.39503 -11.34580 -3.20191  1.000 38.31488 ? 2332 HOH A O    1 
HETATM 6333 O  O    . HOH S 6 .   ? -0.01923  -27.17114 -6.61489  1.000 33.96436 ? 2333 HOH A O    1 
HETATM 6334 O  O    . HOH S 6 .   ? -36.95228 -26.77693 -25.86767 1.000 36.22253 ? 2334 HOH A O    1 
HETATM 6335 O  O    . HOH S 6 .   ? -21.92676 -10.95692 -28.43698 1.000 31.25614 ? 2335 HOH A O    1 
HETATM 6336 O  O    . HOH S 6 .   ? -7.00121  -32.76654 1.71794   1.000 33.51430 ? 2336 HOH A O    1 
HETATM 6337 O  O    . HOH S 6 .   ? -32.39424 -24.51115 -1.11215  1.000 31.12455 ? 2337 HOH A O    1 
HETATM 6338 O  O    . HOH S 6 .   ? -34.89241 -26.70747 -24.99351 1.000 33.59063 ? 2338 HOH A O    1 
HETATM 6339 O  O    . HOH S 6 .   ? -0.85648  -23.55421 7.33313   1.000 40.74938 ? 2339 HOH A O    1 
HETATM 6340 O  O    . HOH S 6 .   ? 1.01536   -13.96746 1.39011   1.000 34.90394 ? 2340 HOH A O    1 
HETATM 6341 O  O    . HOH S 6 .   ? -30.12988 -14.97902 0.02471   1.000 33.66169 ? 2341 HOH A O    1 
HETATM 6342 O  O    . HOH S 6 .   ? -6.22978  -21.13082 12.64545  1.000 36.03829 ? 2342 HOH A O    1 
HETATM 6343 O  O    . HOH S 6 .   ? -28.30137 -24.14238 6.72943   1.000 37.99905 ? 2343 HOH A O    1 
HETATM 6344 O  O    . HOH S 6 .   ? -17.59328 -42.33683 -3.19329  1.000 30.94031 ? 2344 HOH A O    1 
HETATM 6345 O  O    . HOH S 6 .   ? -38.99765 -29.39259 -20.94063 1.000 37.20422 ? 2345 HOH A O    1 
HETATM 6346 O  O    . HOH S 6 .   ? -30.46843 -2.01675  -14.99999 1.000 37.48846 ? 2346 HOH A O    1 
HETATM 6347 O  O    . HOH S 6 .   ? -21.63899 -2.12713  -0.90030  1.000 34.80656 ? 2347 HOH A O    1 
HETATM 6348 O  O    . HOH S 6 .   ? -1.92319  -12.06077 -6.82961  1.000 16.86493 ? 2348 HOH A O    1 
HETATM 6349 O  O    . HOH S 6 .   ? -2.61296  -30.91314 -19.78888 1.000 19.75739 ? 2349 HOH A O    1 
HETATM 6350 O  O    . HOH S 6 .   ? -17.42716 -44.31934 -7.23955  1.000 38.07274 ? 2350 HOH A O    1 
HETATM 6351 O  O    . HOH S 6 .   ? -11.51821 -18.23954 -36.73291 1.000 38.52280 ? 2351 HOH A O    1 
HETATM 6352 O  O    . HOH S 6 .   ? -34.68459 -23.35941 -2.23122  1.000 41.85214 ? 2352 HOH A O    1 
HETATM 6353 O  O    . HOH S 6 .   ? -28.15885 -37.99178 -22.21744 1.000 37.84114 ? 2353 HOH A O    1 
HETATM 6354 O  O    . HOH S 6 .   ? -34.37710 -3.14344  -24.46114 1.000 32.85108 ? 2354 HOH A O    1 
HETATM 6355 O  O    . HOH S 6 .   ? -38.47816 -9.50063  -9.81095  1.000 39.19656 ? 2355 HOH A O    1 
HETATM 6356 O  O    . HOH S 6 .   ? -27.48701 -5.26129  -7.30789  1.000 26.15552 ? 2356 HOH A O    1 
HETATM 6357 O  O    . HOH S 6 .   ? -0.10398  -25.96971 -8.50468  1.000 20.26007 ? 2357 HOH A O    1 
HETATM 6358 O  O    . HOH S 6 .   ? -4.45705  -39.35979 -4.17880  1.000 34.66181 ? 2358 HOH A O    1 
HETATM 6359 O  O    . HOH S 6 .   ? -7.70912  -11.61897 -30.73328 1.000 29.57436 ? 2359 HOH A O    1 
HETATM 6360 O  O    . HOH S 6 .   ? -32.65900 -31.50122 -23.41387 1.000 30.50078 ? 2360 HOH A O    1 
HETATM 6361 O  O    . HOH S 6 .   ? -8.37062  -9.04185  -30.14770 1.000 41.78372 ? 2361 HOH A O    1 
HETATM 6362 O  O    . HOH S 6 .   ? -2.68838  -28.21070 -24.72963 1.000 31.33509 ? 2362 HOH A O    1 
HETATM 6363 O  O    . HOH S 6 .   ? -16.47866 -44.19716 -11.01751 1.000 25.35806 ? 2363 HOH A O    1 
HETATM 6364 O  O    . HOH S 6 .   ? -5.54945  -9.33966  -24.17075 1.000 23.74208 ? 2364 HOH A O    1 
HETATM 6365 O  O    . HOH S 6 .   ? -13.40820 -41.77520 -2.63101  1.000 44.08662 ? 2365 HOH A O    1 
HETATM 6366 O  O    . HOH S 6 .   ? 3.21522   -25.20357 -7.62165  1.000 11.84328 ? 2366 HOH A O    1 
HETATM 6367 O  O    . HOH S 6 .   ? -31.85156 -11.14747 -4.03982  1.000 36.86997 ? 2367 HOH A O    1 
HETATM 6368 O  O    . HOH S 6 .   ? -0.38712  -17.01974 -28.54558 1.000 27.06089 ? 2368 HOH A O    1 
HETATM 6369 O  O    . HOH S 6 .   ? -36.24892 -6.96963  -26.25452 1.000 31.55617 ? 2369 HOH A O    1 
HETATM 6370 O  O    . HOH S 6 .   ? -13.31585 -39.91301 -4.75033  1.000 25.24226 ? 2370 HOH A O    1 
HETATM 6371 O  O    . HOH S 6 .   ? -30.95998 -14.08704 -2.39330  1.000 38.08854 ? 2371 HOH A O    1 
HETATM 6372 O  O    . HOH S 6 .   ? -2.59323  0.52221   -16.48369 1.000 21.57340 ? 2372 HOH A O    1 
HETATM 6373 O  O    . HOH S 6 .   ? -2.33557  -25.19281 5.52224   1.000 31.90358 ? 2373 HOH A O    1 
HETATM 6374 O  O    . HOH S 6 .   ? -27.11022 -23.78567 -18.81220 1.000 13.68561 ? 2374 HOH A O    1 
HETATM 6375 O  O    . HOH S 6 .   ? -1.68176  -36.56889 -21.50209 1.000 33.83276 ? 2375 HOH A O    1 
HETATM 6376 O  O    . HOH S 6 .   ? -39.74175 -26.30641 -10.25381 1.000 30.41393 ? 2376 HOH A O    1 
HETATM 6377 O  O    . HOH S 6 .   ? -23.85992 -7.75106  -24.58318 1.000 40.95204 ? 2377 HOH A O    1 
HETATM 6378 O  O    . HOH S 6 .   ? -2.13225  -6.84589  -16.59113 1.000 35.72246 ? 2378 HOH A O    1 
HETATM 6379 O  O    . HOH S 6 .   ? -8.02454  -11.79223 -34.74223 1.000 43.73921 ? 2379 HOH A O    1 
HETATM 6380 O  O    . HOH S 6 .   ? -11.42287 -42.44164 -5.96938  1.000 39.52292 ? 2380 HOH A O    1 
HETATM 6381 O  O    . HOH S 6 .   ? -3.59069  -12.98654 -30.62482 1.000 33.70117 ? 2381 HOH A O    1 
HETATM 6382 O  O    . HOH S 6 .   ? -18.82187 -7.21665  14.34262  1.000 41.08626 ? 2382 HOH A O    1 
HETATM 6383 O  O    . HOH S 6 .   ? -7.63948  -13.49055 -32.61719 1.000 24.56060 ? 2383 HOH A O    1 
HETATM 6384 O  O    . HOH S 6 .   ? -35.91404 -17.22051 -28.34874 1.000 44.03662 ? 2384 HOH A O    1 
HETATM 6385 O  O    . HOH S 6 .   ? -23.40782 -28.49106 -26.12294 1.000 30.03757 ? 2385 HOH A O    1 
HETATM 6386 O  O    . HOH S 6 .   ? -4.64479  2.02204   -14.96997 1.000 20.14164 ? 2386 HOH A O    1 
HETATM 6387 O  O    . HOH S 6 .   ? -26.02443 -2.50667  -7.07997  1.000 39.76769 ? 2387 HOH A O    1 
HETATM 6388 O  O    . HOH S 6 .   ? -14.52451 -44.33348 -9.58778  1.000 32.32995 ? 2388 HOH A O    1 
HETATM 6389 O  O    . HOH S 6 .   ? -22.31076 -17.36559 -34.68097 1.000 37.61743 ? 2389 HOH A O    1 
HETATM 6390 O  O    . HOH S 6 .   ? -22.84974 -30.17331 9.05613   1.000 32.75369 ? 2390 HOH A O    1 
HETATM 6391 O  O    . HOH S 6 .   ? -15.16510 -32.96057 11.41353  1.000 40.27301 ? 2391 HOH A O    1 
HETATM 6392 O  O    . HOH S 6 .   ? -42.47605 -18.76163 -3.22344  1.000 42.24167 ? 2392 HOH A O    1 
HETATM 6393 O  O    . HOH S 6 .   ? -24.65276 1.11377   -10.59168 1.000 36.52520 ? 2393 HOH A O    1 
HETATM 6394 O  O    . HOH S 6 .   ? -19.03309 -5.06877  -26.52789 1.000 36.62783 ? 2394 HOH A O    1 
HETATM 6395 O  O    . HOH S 6 .   ? 3.02321   -5.77361  1.71125   1.000 36.53573 ? 2395 HOH A O    1 
HETATM 6396 O  O    . HOH S 6 .   ? -24.16483 -32.35264 -28.66992 1.000 36.16199 ? 2396 HOH A O    1 
HETATM 6397 O  O    . HOH S 6 .   ? -37.32215 -20.87079 -19.70549 1.000 20.98912 ? 2397 HOH A O    1 
HETATM 6398 O  O    . HOH S 6 .   ? -26.20454 -11.12763 -28.58155 1.000 42.07059 ? 2398 HOH A O    1 
HETATM 6399 O  O    . HOH S 6 .   ? -9.34021  -15.97405 -35.73343 1.000 42.67856 ? 2399 HOH A O    1 
HETATM 6400 O  O    . HOH S 6 .   ? -0.00000  -3.38840  -15.48750 0.50  18.70463 ? 2400 HOH A O    1 
HETATM 6401 O  O    . HOH S 6 .   ? -13.56210 -42.05603 -30.44260 1.000 31.66145 ? 2401 HOH A O    1 
HETATM 6402 O  O    . HOH S 6 .   ? -30.82638 -5.67216  -13.22240 1.000 32.20098 ? 2402 HOH A O    1 
HETATM 6403 O  O    . HOH S 6 .   ? -5.49191  -18.72551 13.35297  1.000 37.95957 ? 2403 HOH A O    1 
HETATM 6404 O  O    . HOH S 6 .   ? -40.62274 -10.54345 -11.08492 1.000 27.01352 ? 2404 HOH A O    1 
HETATM 6405 O  O    . HOH S 6 .   ? -35.33834 -2.96274  -19.78382 1.000 37.80692 ? 2405 HOH A O    1 
HETATM 6406 O  O    . HOH S 6 .   ? -14.86980 -40.22009 -30.99051 1.000 41.34682 ? 2406 HOH A O    1 
HETATM 6407 O  O    . HOH S 6 .   ? -3.76879  -29.53460 4.26732   1.000 40.95204 ? 2407 HOH A O    1 
HETATM 6408 O  O    . HOH S 6 .   ? -19.85986 -27.70300 -1.20227  1.000 23.30255 ? 2408 HOH A O    1 
HETATM 6409 O  O    . HOH S 6 .   ? -12.40711 -7.36203  -31.66814 1.000 46.88433 ? 2409 HOH A O    1 
HETATM 6410 O  O    . HOH S 6 .   ? -1.27207  -8.69545  9.02982   1.000 36.51466 ? 2410 HOH A O    1 
HETATM 6411 O  O    . HOH S 6 .   ? 1.97005   -7.92283  -0.70392  1.000 37.04367 ? 2411 HOH A O    1 
HETATM 6412 O  O    . HOH S 6 .   ? -31.77298 -1.12940  -17.19477 1.000 42.33378 ? 2412 HOH A O    1 
HETATM 6413 O  O    . HOH S 6 .   ? -16.82251 -27.22324 14.41350  1.000 42.66803 ? 2413 HOH A O    1 
HETATM 6414 O  O    . HOH S 6 .   ? -29.29060 -35.45988 -22.32699 1.000 40.02035 ? 2414 HOH A O    1 
HETATM 6415 O  O    . HOH S 6 .   ? -19.34962 -20.11127 11.53066  1.000 28.45317 ? 2415 HOH A O    1 
HETATM 6416 O  O    . HOH S 6 .   ? -4.24017  -13.37212 13.90131  1.000 39.09129 ? 2416 HOH A O    1 
HETATM 6417 O  O    . HOH S 6 .   ? -37.32946 -27.70914 -13.52703 1.000 38.00695 ? 2417 HOH A O    1 
HETATM 6418 O  O    . HOH S 6 .   ? -18.69146 -43.54633 -5.41390  1.000 40.88098 ? 2418 HOH A O    1 
HETATM 6419 O  O    . HOH S 6 .   ? -35.50969 -31.93619 -3.26307  1.000 40.99941 ? 2419 HOH A O    1 
HETATM 6420 O  O    . HOH S 6 .   ? -17.63940 -22.10576 13.15269  1.000 41.09416 ? 2420 HOH A O    1 
HETATM 6421 O  O    . HOH S 6 .   ? -16.28306 -7.24651  14.20640  1.000 40.85466 ? 2421 HOH A O    1 
HETATM 6422 O  O    . HOH S 6 .   ? -39.57465 -26.80513 -21.46227 1.000 33.95383 ? 2422 HOH A O    1 
HETATM 6423 O  O    . HOH S 6 .   ? -1.17570  -11.28052 -16.07155 1.000 32.25626 ? 2423 HOH A O    1 
HETATM 6424 O  O    . HOH S 6 .   ? -26.18134 -31.30963 -26.65636 1.000 27.96627 ? 2424 HOH A O    1 
HETATM 6425 O  O    . HOH S 6 .   ? -10.84810 -28.65946 12.62486  1.000 35.23556 ? 2425 HOH A O    1 
HETATM 6426 O  O    . HOH S 6 .   ? -27.48892 -35.32220 -15.03096 1.000 29.59805 ? 2426 HOH A O    1 
HETATM 6427 O  O    . HOH S 6 .   ? -6.16026  -45.01356 -18.67397 1.000 48.23186 ? 2427 HOH A O    1 
HETATM 6428 O  O    . HOH S 6 .   ? -16.06070 -47.98657 -19.12881 1.000 44.83671 ? 2428 HOH A O    1 
HETATM 6429 O  O    . HOH S 6 .   ? -7.01877  -39.30112 -3.76231  1.000 27.11353 ? 2429 HOH A O    1 
HETATM 6430 O  O    . HOH S 6 .   ? -24.86314 -4.66863  -3.65577  1.000 34.19597 ? 2430 HOH A O    1 
HETATM 6431 O  O    . HOH S 6 .   ? -21.58076 -28.51292 -38.31039 1.000 35.89354 ? 2431 HOH A O    1 
HETATM 6432 O  O    . HOH S 6 .   ? -0.00000  -34.86025 -15.48750 0.50  28.43475 ? 2432 HOH A O    1 
HETATM 6433 O  O    . HOH S 6 .   ? 0.40698   3.47778   -11.95515 1.000 25.46597 ? 2433 HOH A O    1 
HETATM 6434 O  O    . HOH S 6 .   ? -27.73536 -37.40490 -16.97443 1.000 37.06210 ? 2434 HOH A O    1 
HETATM 6435 O  O    . HOH S 6 .   ? -34.45992 -31.22893 -14.53047 1.000 37.09894 ? 2435 HOH A O    1 
HETATM 6436 O  O    . HOH S 6 .   ? -29.83441 -23.79791 -1.84371  1.000 23.29466 ? 2436 HOH A O    1 
HETATM 6437 O  O    . HOH S 6 .   ? -39.24661 -6.08269  -17.79929 1.000 29.75332 ? 2437 HOH A O    1 
HETATM 6438 O  O    . HOH S 6 .   ? -3.40426  -4.54649  -16.58409 1.000 35.36189 ? 2438 HOH A O    1 
HETATM 6439 O  O    . HOH S 6 .   ? -31.10975 -31.24119 2.97639   1.000 34.59602 ? 2439 HOH A O    1 
HETATM 6440 O  O    . HOH S 6 .   ? -4.84151  3.44982   -17.62434 1.000 37.62006 ? 2440 HOH A O    1 
HETATM 6441 O  O    . HOH S 6 .   ? -26.42914 -39.00708 -17.95632 1.000 37.49110 ? 2441 HOH A O    1 
HETATM 6442 O  O    . HOH S 6 .   ? -6.35783  -17.29499 15.80188  1.000 44.61826 ? 2442 HOH A O    1 
HETATM 6443 O  O    . HOH S 6 .   ? -0.55316  -11.44043 -8.98167  1.000 20.99964 ? 2443 HOH A O    1 
HETATM 6444 O  O    . HOH S 6 .   ? -37.90843 -21.11682 -29.58932 1.000 38.55438 ? 2444 HOH A O    1 
HETATM 6445 O  O    . HOH S 6 .   ? 1.64903   -9.81656  -8.87823  1.000 23.88946 ? 2445 HOH A O    1 
HETATM 6446 O  O    . HOH S 6 .   ? -34.75513 -18.87495 -30.44102 1.000 34.37494 ? 2446 HOH A O    1 
HETATM 6447 O  O    . HOH S 6 .   ? -12.53230 -32.46622 9.96042   1.000 37.80692 ? 2447 HOH A O    1 
HETATM 6448 O  O    . HOH S 6 .   ? -30.54226 -12.49684 -28.28541 1.000 35.50928 ? 2448 HOH A O    1 
HETATM 6449 O  O    . HOH S 6 .   ? 0.24352   -13.28401 -5.64110  1.000 25.38701 ? 2449 HOH A O    1 
HETATM 6450 O  O    . HOH S 6 .   ? -17.14232 -45.26694 -22.58756 1.000 24.45269 ? 2450 HOH A O    1 
HETATM 6451 O  O    . HOH S 6 .   ? -0.65827  -28.87808 -25.50991 0.831 17.30178 ? 2451 HOH A O    1 
HETATM 6452 O  O    . HOH S 6 .   ? -0.82905  -9.35234  -14.75847 0.997 34.18806 ? 2452 HOH A O    1 
HETATM 6453 O  O    . HOH S 6 .   ? 3.34463   -7.59586  -3.14318  1.000 34.03805 ? 2453 HOH A O    1 
HETATM 6454 O  O    . HOH S 6 .   ? -24.39479 -23.30095 9.62307   1.000 29.66648 ? 2454 HOH A O    1 
HETATM 6455 O  O    . HOH S 6 .   ? -0.99617  -0.41609  -0.67574  0.776 42.83910 ? 2455 HOH A O    1 
HETATM 6456 O  O    . HOH S 6 .   ? -41.89859 -6.35014  -20.59191 1.000 34.18017 ? 2456 HOH A O    1 
HETATM 6457 O  O    . HOH S 6 .   ? -0.21344  -34.82862 -17.80616 1.000 22.07609 ? 2457 HOH A O    1 
HETATM 6458 O  O    . HOH S 6 .   ? -6.06114  -8.88806  -28.29900 1.000 46.72115 ? 2458 HOH A O    1 
HETATM 6459 O  O    . HOH S 6 .   ? -2.10433  -15.56169 -7.88939  1.000 28.82690 ? 2459 HOH A O    1 
HETATM 6460 O  O    . HOH S 6 .   ? -41.40793 -12.11743 -17.52715 1.000 28.09786 ? 2460 HOH A O    1 
HETATM 6461 O  O    . HOH S 6 .   ? -25.42562 -38.46135 -5.85903  1.000 34.33282 ? 2461 HOH A O    1 
HETATM 6462 O  O    . HOH S 6 .   ? -0.00000  -5.78803  -15.48750 0.50  38.57017 ? 2462 HOH A O    1 
HETATM 6463 O  O    . HOH S 6 .   ? -28.96827 -33.89962 -25.70441 1.000 47.32122 ? 2463 HOH A O    1 
HETATM 6464 O  O    . HOH S 6 .   ? -12.78159 -5.94814  17.39221  1.000 27.50569 ? 2464 HOH A O    1 
HETATM 6465 O  O    . HOH S 6 .   ? -24.50442 -39.24150 -1.85528  1.000 31.20876 ? 2465 HOH A O    1 
HETATM 6466 O  O    . HOH S 6 .   ? -31.95990 -9.76526  -28.72399 1.000 44.41035 ? 2466 HOH A O    1 
HETATM 6467 O  O    . HOH S 6 .   ? -35.46713 -5.51318  -15.08778 1.000 32.40364 ? 2467 HOH A O    1 
HETATM 6468 O  O    . HOH S 6 .   ? -25.73485 -28.56749 -27.60315 1.000 33.93277 ? 2468 HOH A O    1 
HETATM 6469 O  O    . HOH S 6 .   ? -1.11916  -12.77670 -27.98820 1.000 32.62735 ? 2469 HOH A O    1 
HETATM 6470 O  O    . HOH S 6 .   ? -11.31973 3.53997   -20.13357 1.000 38.06485 ? 2470 HOH A O    1 
HETATM 6471 O  O    . HOH S 6 .   ? -27.64830 -38.50346 -5.18637  1.000 41.73371 ? 2471 HOH A O    1 
HETATM 6472 O  O    . HOH S 6 .   ? -18.64336 -3.34390  15.06984  1.000 22.71564 ? 2472 HOH A O    1 
HETATM 6473 O  O    . HOH S 6 .   ? -14.24007 -44.99147 -6.39707  1.000 39.67820 ? 2473 HOH A O    1 
HETATM 6474 O  O    . HOH S 6 .   ? -10.14919 -5.76414  16.50434  1.000 23.70260 ? 2474 HOH A O    1 
HETATM 6475 O  O    . HOH S 6 .   ? -9.23613  -13.32307 14.86481  1.000 41.19680 ? 2475 HOH A O    1 
HETATM 6476 O  O    . HOH S 6 .   ? -19.92919 -46.59683 -10.32058 1.000 33.73012 ? 2476 HOH A O    1 
HETATM 6477 O  O    . HOH S 6 .   ? -30.19337 -29.27467 -26.63482 1.000 30.19548 ? 2477 HOH A O    1 
HETATM 6478 O  O    . HOH S 6 .   ? -17.48834 -34.58213 11.23582  1.000 39.51502 ? 2478 HOH A O    1 
HETATM 6479 O  O    . HOH S 6 .   ? -8.53792  4.45090   -14.98442 1.000 29.10588 ? 2479 HOH A O    1 
HETATM 6480 O  O    . HOH S 6 .   ? 3.40072   -9.43677  -4.49039  1.000 34.91973 ? 2480 HOH A O    1 
HETATM 6481 O  O    . HOH S 6 .   ? -13.82106 -44.81464 -27.16712 1.000 36.28306 ? 2481 HOH A O    1 
HETATM 6482 O  O    . HOH S 6 .   ? -0.22683  -21.06276 8.33723   1.000 36.98578 ? 2482 HOH A O    1 
HETATM 6483 O  O    . HOH S 6 .   ? -30.87994 -34.67521 -13.20118 1.000 33.96699 ? 2483 HOH A O    1 
HETATM 6484 O  O    . HOH S 6 .   ? -14.75500 -46.13386 -23.53272 1.000 34.03805 ? 2484 HOH A O    1 
HETATM 6485 O  O    . HOH S 6 .   ? -12.30479 -44.45737 -10.96141 1.000 37.10157 ? 2485 HOH A O    1 
HETATM 6486 O  O    . HOH S 6 .   ? -3.60842  3.88994   -13.24007 1.000 24.72904 ? 2486 HOH A O    1 
HETATM 6487 O  O    . HOH S 6 .   ? -33.65567 -5.72914  -13.45064 1.000 39.87822 ? 2487 HOH A O    1 
HETATM 6488 O  O    . HOH S 6 .   ? -14.94808 -5.57334  15.78056  1.000 30.99558 ? 2488 HOH A O    1 
HETATM 6489 O  O    . HOH S 6 .   ? -0.06415  -13.92072 -21.10171 1.000 36.18042 ? 2489 HOH A O    1 
HETATM 6490 O  O    . HOH S 6 .   ? -4.57348  -27.66221 -32.76324 1.000 34.35124 ? 2490 HOH A O    1 
HETATM 6491 O  O    . HOH S 6 .   ? -27.44679 -39.18350 -9.35667  1.000 35.53823 ? 2491 HOH A O    1 
HETATM 6492 O  O    . HOH S 6 .   ? -34.68126 -25.39881 -29.57395 1.000 48.97931 ? 2492 HOH A O    1 
HETATM 6493 O  O    . HOH S 6 .   ? -16.29533 -45.68777 -13.79857 1.000 36.44097 ? 2493 HOH A O    1 
HETATM 6494 O  O    . HOH S 6 .   ? -27.45441 -32.66070 5.30956   1.000 35.55139 ? 2494 HOH A O    1 
HETATM 6495 O  O    . HOH S 6 .   ? -41.07100 -5.36016  -15.48750 0.50  36.39096 ? 2495 HOH A O    1 
HETATM 6496 O  O    . HOH S 6 .   ? -10.92925 -31.05951 12.02839  1.000 35.28557 ? 2496 HOH A O    1 
HETATM 6497 O  O    . HOH S 6 .   ? -28.30102 -27.69165 -27.11222 1.000 30.24812 ? 2497 HOH A O    1 
HETATM 6498 O  O    . HOH S 6 .   ? -25.82890 -30.57018 8.96035   1.000 45.03937 ? 2498 HOH A O    1 
HETATM 6499 O  O    . HOH S 6 .   ? -1.87314  -11.09582 -29.35253 1.000 37.45951 ? 2499 HOH A O    1 
HETATM 6500 O  O    . HOH S 6 .   ? -29.15539 -31.67938 -27.12273 1.000 41.13627 ? 2500 HOH A O    1 
HETATM 6501 O  O    . HOH S 6 .   ? -1.07629  2.84824   -16.26478 1.000 27.15564 ? 2501 HOH A O    1 
HETATM 6502 O  O    . HOH S 6 .   ? -2.13195  5.08593   -15.15304 1.000 37.48583 ? 2502 HOH A O    1 
HETATM 6503 O  O    . HOH S 6 .   ? -42.89949 -4.65782  -18.04097 1.000 44.48404 ? 2503 HOH A O    1 
HETATM 6504 O  O    . HOH S 6 .   ? -1.27850  12.73856  -27.23661 1.000 33.87224 ? 2504 HOH A O    1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
1    N  N   . LYS A 1   ? 0.46550 0.40230 0.39680 -0.01840 0.00870  -0.05130 1460 LYS A N   
2    C  CA  . LYS A 1   ? 0.44700 0.39750 0.38910 -0.01790 0.00960  -0.03940 1460 LYS A CA  
3    C  C   . LYS A 1   ? 0.41290 0.38380 0.39880 -0.01880 -0.01720 -0.02300 1460 LYS A C   
4    O  O   . LYS A 1   ? 0.47030 0.39720 0.45370 -0.00230 -0.01250 -0.00310 1460 LYS A O   
5    C  CB  . LYS A 1   ? 0.47090 0.40530 0.40310 -0.02070 0.01670  -0.02910 1460 LYS A CB  
7    N  N   . LEU A 2   ? 0.30830 0.35700 0.34070 -0.02890 -0.04380 -0.02110 1461 LEU A N   
8    C  CA  . LEU A 2   ? 0.27360 0.32950 0.31240 -0.03080 0.00630  -0.02710 1461 LEU A CA  
9    C  C   . LEU A 2   ? 0.22270 0.31880 0.28180 -0.02090 0.02840  -0.04750 1461 LEU A C   
10   O  O   . LEU A 2   ? 0.23070 0.34909 0.36430 -0.01000 0.04960  -0.07660 1461 LEU A O   
11   C  CB  . LEU A 2   ? 0.30850 0.31660 0.32290 -0.02560 0.00790  -0.01820 1461 LEU A CB  
12   C  CG  . LEU A 2   ? 0.33180 0.31590 0.31510 -0.02290 -0.00280 -0.02740 1461 LEU A CG  
13   C  CD1 . LEU A 2   ? 0.36190 0.32360 0.35490 -0.02080 -0.01290 -0.02900 1461 LEU A CD1 
14   C  CD2 . LEU A 2   ? 0.29120 0.31660 0.30950 -0.03070 0.02040  -0.03360 1461 LEU A CD2 
26   N  N   . VAL A 3   ? 0.17260 0.27530 0.22730 -0.02960 0.01390  -0.03800 1462 VAL A N   
27   C  CA  . VAL A 3   ? 0.18130 0.24670 0.22970 -0.02230 0.03890  -0.02770 1462 VAL A CA  
28   C  C   . VAL A 3   ? 0.17030 0.21770 0.22800 -0.02680 0.02420  -0.02380 1462 VAL A C   
29   O  O   . VAL A 3   ? 0.17570 0.20190 0.20420 -0.03540 0.03560  -0.00310 1462 VAL A O   
30   C  CB  . VAL A 3   ? 0.24260 0.25220 0.25720 -0.04410 -0.00340 0.01750  1462 VAL A CB  
31   C  CG1 . VAL A 3   ? 0.28170 0.25380 0.29880 -0.05900 -0.03960 0.01880  1462 VAL A CG1 
32   C  CG2 . VAL A 3   ? 0.28510 0.26540 0.28380 -0.04180 -0.00560 0.02660  1462 VAL A CG2 
42   N  N   . ARG A 4   ? 0.15260 0.21450 0.21810 -0.01460 0.05320  -0.03730 1463 ARG A N   
43   C  CA  . ARG A 4   ? 0.16520 0.21110 0.21530 -0.00630 0.02950  -0.06390 1463 ARG A CA  
44   C  C   . ARG A 4   ? 0.16800 0.18920 0.22080 -0.04080 0.03480  -0.05360 1463 ARG A C   
45   O  O   . ARG A 4   ? 0.19510 0.21959 0.28510 -0.07050 0.06440  -0.04830 1463 ARG A O   
46   C  CB  . ARG A 4   ? 0.19740 0.23260 0.22250 0.00770  0.00470  -0.06040 1463 ARG A CB  
47   C  CG  . ARG A 4   ? 0.22020 0.24850 0.25890 0.03730  -0.00340 -0.03940 1463 ARG A CG  
48   C  CD  . ARG A 4   ? 0.23570 0.25880 0.27820 0.03550  0.02740  -0.04050 1463 ARG A CD  
49   N  NE  . ARG A 4   ? 0.22600 0.27470 0.29290 0.02290  0.04310  -0.01060 1463 ARG A NE  
50   C  CZ  . ARG A 4   ? 0.24890 0.29130 0.30590 0.00810  0.05330  -0.02600 1463 ARG A CZ  
51   N  NH1 . ARG A 4   ? 0.29650 0.30080 0.34610 0.01420  0.10480  -0.04570 1463 ARG A NH1 
52   N  NH2 . ARG A 4   ? 0.21770 0.29360 0.29900 -0.00990 0.04860  -0.00910 1463 ARG A NH2 
66   N  N   . LEU A 5   ? 0.16150 0.15720 0.18210 -0.01760 0.03320  -0.03710 1464 LEU A N   
67   C  CA  . LEU A 5   ? 0.13580 0.14880 0.16850 -0.03690 0.04270  -0.02700 1464 LEU A CA  
68   C  C   . LEU A 5   ? 0.13850 0.14699 0.15780 -0.01670 0.02170  -0.01080 1464 LEU A C   
69   O  O   . LEU A 5   ? 0.14170 0.13150 0.20640 -0.01330 0.03510  -0.01880 1464 LEU A O   
70   C  CB  . LEU A 5   ? 0.14810 0.13950 0.17710 -0.03680 0.03300  -0.01840 1464 LEU A CB  
71   C  CG  . LEU A 5   ? 0.20260 0.16230 0.20230 -0.02520 0.00390  -0.02260 1464 LEU A CG  
72   C  CD1 . LEU A 5   ? 0.21360 0.16890 0.18580 -0.00880 -0.04880 -0.04230 1464 LEU A CD1 
73   C  CD2 . LEU A 5   ? 0.25280 0.16700 0.23750 -0.02110 -0.00920 -0.00920 1464 LEU A CD2 
85   N  N   . PRO A 6   ? 0.13530 0.14260 0.19040 -0.01880 0.01870  -0.02650 1465 PRO A N   
86   C  CA  . PRO A 6   ? 0.13650 0.14400 0.19220 -0.01760 0.02180  -0.03250 1465 PRO A CA  
87   C  C   . PRO A 6   ? 0.14030 0.12540 0.21140 -0.00870 0.05820  -0.03290 1465 PRO A C   
88   O  O   . PRO A 6   ? 0.14890 0.13250 0.21440 -0.00890 0.02820  -0.03040 1465 PRO A O   
89   C  CB  . PRO A 6   ? 0.13920 0.16479 0.23690 -0.02450 0.02610  -0.03370 1465 PRO A CB  
90   C  CG  . PRO A 6   ? 0.17650 0.16849 0.22730 -0.03430 0.00300  -0.03920 1465 PRO A CG  
91   C  CD  . PRO A 6   ? 0.16910 0.14850 0.18560 -0.03930 0.00770  -0.02500 1465 PRO A CD  
99   N  N   . GLY A 7   ? 0.13860 0.11990 0.22720 -0.00120 0.05300  -0.02540 1466 GLY A N   
100  C  CA  . GLY A 7   ? 0.15200 0.11040 0.20880 0.00430  0.04040  -0.00630 1466 GLY A CA  
101  C  C   . GLY A 7   ? 0.11380 0.10790 0.19230 -0.01330 0.02610  -0.01160 1466 GLY A C   
102  O  O   . GLY A 7   ? 0.11370 0.10180 0.22200 0.00110  -0.00470 -0.01150 1466 GLY A O   
106  N  N   . LEU A 8   ? 0.10130 0.10520 0.18180 -0.01390 0.02410  -0.02880 1467 LEU A N   
107  C  CA  . LEU A 8   ? 0.11060 0.10810 0.16900 -0.01810 0.00600  -0.03270 1467 LEU A CA  
108  C  C   . LEU A 8   ? 0.08480 0.10290 0.19300 -0.00180 0.00740  -0.01300 1467 LEU A C   
109  O  O   . LEU A 8   ? 0.11050 0.10230 0.19990 -0.02180 0.01430  -0.01830 1467 LEU A O   
110  C  CB  . LEU A 8   ? 0.11570 0.11740 0.13970 -0.03070 0.01170  -0.01090 1467 LEU A CB  
111  C  CG  . LEU A 8   ? 0.12170 0.13650 0.15290 -0.03570 0.00260  -0.01380 1467 LEU A CG  
112  C  CD1 . LEU A 8   ? 0.15440 0.15459 0.14400 -0.02910 -0.01920 -0.00800 1467 LEU A CD1 
113  C  CD2 . LEU A 8   ? 0.13720 0.12570 0.14750 -0.02370 0.00580  -0.02840 1467 LEU A CD2 
125  N  N   . ILE A 9   ? 0.09630 0.09680 0.16450 -0.00160 0.02200  -0.01280 1468 ILE A N   
126  C  CA  . ILE A 9   ? 0.09790 0.09720 0.16170 -0.00160 0.02090  0.00400  1468 ILE A CA  
127  C  C   . ILE A 9   ? 0.11290 0.09110 0.16190 0.00660  0.04140  0.00560  1468 ILE A C   
128  O  O   . ILE A 9   ? 0.10990 0.09920 0.17450 0.00950  0.03290  0.01630  1468 ILE A O   
129  C  CB  . ILE A 9   ? 0.09210 0.10300 0.18020 -0.00830 0.00880  -0.00790 1468 ILE A CB  
130  C  CG1 . ILE A 9   ? 0.08800 0.11070 0.19750 0.00710  0.00960  -0.00760 1468 ILE A CG1 
131  C  CG2 . ILE A 9   ? 0.09500 0.11210 0.18820 0.00110  0.00690  0.00280  1468 ILE A CG2 
132  C  CD1 . ILE A 9   ? 0.09550 0.12110 0.24650 0.01130  -0.00700 -0.00400 1468 ILE A CD1 
144  N  N   . ASP A 10  ? 0.10180 0.09380 0.14320 0.00090  0.01990  -0.00870 1469 ASP A N   
145  C  CA  . ASP A 10  ? 0.09050 0.09910 0.15170 0.00760  0.02000  -0.00940 1469 ASP A CA  
146  C  C   . ASP A 10  ? 0.09320 0.09580 0.15930 0.01200  0.00140  -0.00190 1469 ASP A C   
147  O  O   . ASP A 10  ? 0.10760 0.09690 0.15030 -0.00220 -0.00480 0.00460  1469 ASP A O   
148  C  CB  . ASP A 10  ? 0.08820 0.11230 0.11440 -0.00360 -0.00500 0.00750  1469 ASP A CB  
149  C  CG  . ASP A 10  ? 0.10830 0.12420 0.10980 -0.00710 -0.02200 0.00310  1469 ASP A CG  
150  O  OD1 . ASP A 10  ? 0.09770 0.12420 0.14770 -0.00880 -0.00250 -0.02750 1469 ASP A OD1 
151  O  OD2 . ASP A 10  ? 0.12630 0.14459 0.16620 0.02890  -0.03460 -0.02240 1469 ASP A OD2 
156  N  N   . VAL A 11  ? 0.08010 0.08710 0.15540 0.00080  0.00150  -0.02130 1470 VAL A N   
157  C  CA  . VAL A 11  ? 0.09610 0.09270 0.16320 0.00570  0.00530  -0.02730 1470 VAL A CA  
158  C  C   . VAL A 11  ? 0.09980 0.09460 0.16240 -0.00110 -0.01580 -0.00750 1470 VAL A C   
159  O  O   . VAL A 11  ? 0.08310 0.10270 0.15180 -0.00360 -0.00550 0.00700  1470 VAL A O   
160  C  CB  . VAL A 11  ? 0.08650 0.10040 0.17960 -0.01680 0.00120  -0.02140 1470 VAL A CB  
161  C  CG1 . VAL A 11  ? 0.09360 0.11110 0.18580 -0.01200 0.00020  -0.02670 1470 VAL A CG1 
162  C  CG2 . VAL A 11  ? 0.10030 0.10240 0.18680 -0.01930 0.01250  -0.03330 1470 VAL A CG2 
172  N  N   . HIS A 12  ? 0.09450 0.09310 0.13940 -0.00170 0.00300  -0.01220 1471 HIS A N   
173  C  CA  . HIS A 12  ? 0.08550 0.09530 0.12640 0.01390  0.00800  -0.01280 1471 HIS A CA  
174  C  C   . HIS A 12  ? 0.08930 0.09990 0.14470 0.00890  0.00590  -0.00160 1471 HIS A C   
175  O  O   . HIS A 12  ? 0.09000 0.10010 0.17190 -0.00660 0.00620  -0.01210 1471 HIS A O   
176  C  CB  . HIS A 12  ? 0.09300 0.09020 0.12460 0.00740  0.00930  -0.01670 1471 HIS A CB  
177  C  CG  . HIS A 12  ? 0.10010 0.09660 0.15420 -0.00080 -0.00370 -0.01580 1471 HIS A CG  
178  N  ND1 . HIS A 12  ? 0.10100 0.10030 0.16930 -0.00530 0.00980  -0.02180 1471 HIS A ND1 
179  C  CD2 . HIS A 12  ? 0.08500 0.08790 0.18400 -0.00350 0.00390  -0.01700 1471 HIS A CD2 
180  C  CE1 . HIS A 12  ? 0.08230 0.11180 0.17650 -0.00720 0.04030  -0.02750 1471 HIS A CE1 
181  N  NE2 . HIS A 12  ? 0.09810 0.11299 0.16280 -0.00330 0.01810  0.00010  1471 HIS A NE2 
188  N  N   . VAL A 13  ? 0.08670 0.10430 0.15560 -0.01430 -0.01980 0.00450  1472 VAL A N   
189  C  CA  . VAL A 13  ? 0.09990 0.11940 0.14840 -0.00700 -0.00370 -0.00940 1472 VAL A CA  
190  C  C   . VAL A 13  ? 0.09150 0.12400 0.14000 -0.00360 -0.00190 0.00010  1472 VAL A C   
191  O  O   . VAL A 13  ? 0.08970 0.14189 0.16680 -0.00470 0.00010  -0.00470 1472 VAL A O   
192  C  CB  . VAL A 13  ? 0.11270 0.12210 0.13870 -0.01140 -0.00760 -0.02450 1472 VAL A CB  
193  C  CG1 . VAL A 13  ? 0.16220 0.12240 0.14910 -0.00560 0.02200  -0.01330 1472 VAL A CG1 
194  C  CG2 . VAL A 13  ? 0.11200 0.12540 0.18520 0.00210  -0.00410 -0.02180 1472 VAL A CG2 
204  N  N   . HIS A 14  ? 0.08840 0.10550 0.16220 -0.00420 -0.00920 0.00130  1473 HIS A N   
205  C  CA  . HIS A 14  ? 0.08360 0.11620 0.14510 -0.01090 -0.00110 0.00140  1473 HIS A CA  
206  C  C   . HIS A 14  ? 0.09260 0.11490 0.15530 -0.01480 -0.01720 0.02020  1473 HIS A C   
207  O  O   . HIS A 14  ? 0.10460 0.12690 0.17750 -0.01440 -0.01510 0.02320  1473 HIS A O   
208  C  CB  . HIS A 14  ? 0.08550 0.12000 0.16190 -0.01210 0.01270  0.01830  1473 HIS A CB  
209  C  CG  . HIS A 14  ? 0.08730 0.12779 0.11020 -0.01610 0.00140  0.00940  1473 HIS A CG  
210  N  ND1 . HIS A 14  ? 0.11020 0.12400 0.10600 -0.02110 -0.00950 0.01300  1473 HIS A ND1 
211  C  CD2 . HIS A 14  ? 0.08740 0.11710 0.17930 -0.00740 -0.01610 -0.02500 1473 HIS A CD2 
212  C  CE1 . HIS A 14  ? 0.11470 0.12629 0.10870 -0.01000 -0.02830 0.01930  1473 HIS A CE1 
213  N  NE2 . HIS A 14  ? 0.08750 0.10710 0.15110 -0.00020 -0.01800 0.00180  1473 HIS A NE2 
221  N  N   . LEU A 15  ? 0.10550 0.10810 0.15980 -0.01250 -0.01640 0.01730  1474 LEU A N   
222  C  CA  . LEU A 15  ? 0.12130 0.11210 0.17220 -0.01430 0.00110  -0.00040 1474 LEU A CA  
223  C  C   . LEU A 15  ? 0.12280 0.11410 0.16210 -0.01510 -0.00650 -0.01810 1474 LEU A C   
224  O  O   . LEU A 15  ? 0.11880 0.11420 0.22810 -0.01460 0.00450  -0.02000 1474 LEU A O   
225  C  CB  . LEU A 15  ? 0.13340 0.12870 0.18490 -0.01850 0.03260  0.00590  1474 LEU A CB  
226  C  CG  . LEU A 15  ? 0.14660 0.15370 0.17060 -0.01930 0.01960  -0.01060 1474 LEU A CG  
227  C  CD1 . LEU A 15  ? 0.17750 0.15870 0.24530 -0.00760 0.04830  0.02290  1474 LEU A CD1 
228  C  CD2 . LEU A 15  ? 0.18350 0.19199 0.20630 -0.02190 0.03020  -0.00760 1474 LEU A CD2 
240  N  N   . ARG A 16  ? 0.11050 0.12090 0.16330 -0.01080 0.00040  -0.01140 1475 ARG A N   
241  C  CA  . ARG A 16  ? 0.10590 0.12760 0.16840 -0.00760 0.01550  0.01970  1475 ARG A CA  
242  C  C   . ARG A 16  ? 0.09780 0.16150 0.21590 -0.00660 0.02320  0.04470  1475 ARG A C   
243  O  O   . ARG A 16  ? 0.17829 0.22039 0.31080 0.05090  0.09300  0.09170  1475 ARG A O   
244  C  CB  . ARG A 16  ? 0.09680 0.13470 0.19540 -0.01630 -0.00840 0.01310  1475 ARG A CB  
245  C  CG  . ARG A 16  ? 0.10990 0.13400 0.15560 -0.01520 -0.01340 0.01390  1475 ARG A CG  
246  C  CD  . ARG A 16  ? 0.09560 0.13640 0.16420 -0.01700 -0.01590 0.01370  1475 ARG A CD  
247  N  NE  . ARG A 16  ? 0.09440 0.13290 0.16060 -0.01950 -0.03080 0.00860  1475 ARG A NE  
248  C  CZ  . ARG A 16  ? 0.08560 0.14079 0.15540 -0.00340 -0.02710 0.00910  1475 ARG A CZ  
249  N  NH1 . ARG A 16  ? 0.09420 0.12640 0.19220 -0.00490 -0.01630 0.00550  1475 ARG A NH1 
250  N  NH2 . ARG A 16  ? 0.09770 0.14720 0.17160 -0.00500 -0.01640 0.00160  1475 ARG A NH2 
264  N  N   . GLU A 17  ? 0.12450 0.14970 0.21850 0.00730  0.01830  0.04580  1476 GLU A N   
265  C  CA  . GLU A 17  ? 0.11610 0.14230 0.22230 -0.00930 0.00890  0.03330  1476 GLU A CA  
266  C  C   . GLU A 17  ? 0.16370 0.13250 0.22340 -0.02620 0.01470  0.02010  1476 GLU A C   
267  O  O   . GLU A 17  ? 0.17080 0.14350 0.28340 -0.04150 0.01730  0.01080  1476 GLU A O   
268  C  CB  . GLU A 17  ? 0.13610 0.15359 0.19590 -0.00610 0.00130  0.00980  1476 GLU A CB  
269  C  CG  . GLU A 17  ? 0.16330 0.14450 0.20970 -0.01590 -0.01420 0.02270  1476 GLU A CG  
270  C  CD  . GLU A 17  ? 0.14930 0.14820 0.19100 -0.01830 -0.02810 0.02080  1476 GLU A CD  
271  O  OE1 . GLU A 17  ? 0.18920 0.14070 0.20610 -0.00530 0.00080  0.00970  1476 GLU A OE1 
272  O  OE2 . GLU A 17  ? 0.20509 0.15420 0.22010 -0.02880 0.00420  0.03510  1476 GLU A OE2 
279  N  N   . PRO A 18  ? 0.18120 0.14250 0.20120 -0.02040 -0.03720 0.02320  1477 PRO A N   
280  C  CA  . PRO A 18  ? 0.20950 0.15620 0.20770 -0.02770 -0.00010 0.02820  1477 PRO A CA  
281  C  C   . PRO A 18  ? 0.18320 0.17150 0.20850 -0.02710 0.01790  0.00790  1477 PRO A C   
282  O  O   . PRO A 18  ? 0.16280 0.16360 0.20510 -0.01750 0.00590  -0.01080 1477 PRO A O   
283  C  CB  . PRO A 18  ? 0.24780 0.16210 0.23320 -0.02850 -0.02770 0.03260  1477 PRO A CB  
284  C  CG  . PRO A 18  ? 0.25580 0.16130 0.28030 -0.01680 -0.03450 0.03340  1477 PRO A CG  
285  C  CD  . PRO A 18  ? 0.22900 0.15350 0.24330 -0.01900 -0.06150 0.03370  1477 PRO A CD  
293  N  N   . GLY A 19  ? 0.19710 0.18900 0.21540 -0.06490 0.00680  -0.00190 1478 GLY A N   
294  C  CA  . GLY A 19  ? 0.18330 0.21640 0.22930 -0.05830 0.04400  0.01110  1478 GLY A CA  
295  C  C   . GLY A 19  ? 0.17200 0.23500 0.24390 -0.04660 0.03250  0.00480  1478 GLY A C   
296  O  O   . GLY A 19  ? 0.17450 0.26419 0.28890 -0.02980 0.04860  -0.00460 1478 GLY A O   
300  N  N   . GLY A 20  ? 0.15350 0.22560 0.23660 -0.04540 0.00240  -0.00040 1479 GLY A N   
301  C  CA  . GLY A 20  ? 0.14640 0.20720 0.22460 -0.03850 -0.00270 -0.00550 1479 GLY A CA  
302  C  C   . GLY A 20  ? 0.13960 0.18090 0.18370 -0.04370 0.01860  -0.00100 1479 GLY A C   
303  O  O   . GLY A 20  ? 0.13940 0.17390 0.20730 -0.03390 0.00670  0.01570  1479 GLY A O   
307  N  N   . THR A 21  ? 0.15900 0.17600 0.19990 -0.02690 0.04560  0.00000  1480 THR A N   
308  C  CA  . THR A 21  ? 0.12650 0.17590 0.18350 -0.02940 0.02490  0.00310  1480 THR A CA  
309  C  C   . THR A 21  ? 0.12380 0.16670 0.19140 -0.02510 0.04750  0.00340  1480 THR A C   
310  O  O   . THR A 21  ? 0.15420 0.16490 0.23940 -0.02620 0.01630  0.00170  1480 THR A O   
311  C  CB  . THR A 21  ? 0.14670 0.18850 0.21950 -0.02860 0.01920  0.02360  1480 THR A CB  
312  O  OG1 . THR A 21  ? 0.18630 0.19820 0.25860 -0.05330 0.03760  0.05270  1480 THR A OG1 
313  C  CG2 . THR A 21  ? 0.15460 0.20000 0.22050 -0.01020 0.01600  0.00230  1480 THR A CG2 
321  N  N   . HIS A 22  ? 0.11870 0.16620 0.24030 -0.02900 0.02660  0.02970  1481 HIS A N   
322  C  CA  . HIS A 22  ? 0.14120 0.18420 0.23530 -0.02830 0.00770  0.02370  1481 HIS A CA  
323  C  C   . HIS A 22  ? 0.12840 0.16980 0.21750 -0.02350 0.01000  -0.00380 1481 HIS A C   
324  O  O   . HIS A 22  ? 0.13580 0.18629 0.24680 -0.04910 0.01180  -0.01860 1481 HIS A O   
325  C  CB  . HIS A 22  ? 0.12840 0.20500 0.20580 -0.02930 -0.00280 0.04740  1481 HIS A CB  
326  C  CG  . HIS A 22  ? 0.12690 0.21310 0.22080 -0.02810 0.03270  0.03340  1481 HIS A CG  
327  N  ND1 . HIS A 22  ? 0.15410 0.20840 0.22770 -0.01180 0.05190  0.01090  1481 HIS A ND1 
328  C  CD2 . HIS A 22  ? 0.11000 0.22220 0.24970 -0.02490 0.00710  0.02360  1481 HIS A CD2 
329  C  CE1 . HIS A 22  ? 0.16940 0.20850 0.22830 -0.02440 0.03040  -0.00150 1481 HIS A CE1 
330  N  NE2 . HIS A 22  ? 0.14070 0.21780 0.23730 -0.01400 0.04210  0.00580  1481 HIS A NE2 
338  N  N   . LYS A 23  ? 0.11020 0.15440 0.17930 -0.02030 0.01710  -0.00450 1482 LYS A N   
339  C  CA  . LYS A 23  ? 0.11610 0.15630 0.18180 -0.01080 0.00810  0.00820  1482 LYS A CA  
340  C  C   . LYS A 23  ? 0.11460 0.15360 0.15440 -0.01150 0.01410  0.00070  1482 LYS A C   
341  O  O   . LYS A 23  ? 0.11080 0.14640 0.17120 -0.00170 0.00800  -0.00440 1482 LYS A O   
342  C  CB  . LYS A 23  ? 0.11980 0.16010 0.19650 -0.01890 0.00700  -0.00920 1482 LYS A CB  
343  C  CG  . LYS A 23  ? 0.11780 0.16990 0.17780 -0.01280 0.01030  -0.01200 1482 LYS A CG  
344  C  CD  . LYS A 23  ? 0.12350 0.16950 0.18780 -0.01430 0.00120  -0.02630 1482 LYS A CD  
345  C  CE  . LYS A 23  ? 0.14720 0.16120 0.18220 -0.00060 -0.00000 -0.02350 1482 LYS A CE  
346  N  NZ  . LYS A 23  ? 0.12590 0.15640 0.16580 -0.00170 -0.00560 -0.01540 1482 LYS A NZ  
360  N  N   . GLU A 24  ? 0.10910 0.14320 0.20060 -0.01580 0.03290  0.01810  1483 GLU A N   
361  C  CA  . GLU A 24  ? 0.10490 0.12860 0.18630 -0.01410 0.01720  0.00740  1483 GLU A CA  
362  C  C   . GLU A 24  ? 0.12770 0.13250 0.12150 -0.02960 0.03410  0.00010  1483 GLU A C   
363  O  O   . GLU A 24  ? 0.10490 0.14400 0.15380 -0.01970 0.01610  0.01200  1483 GLU A O   
364  C  CB  . GLU A 24  ? 0.10700 0.11900 0.19500 -0.02400 0.01980  -0.00810 1483 GLU A CB  
365  C  CG  . GLU A 24  ? 0.10450 0.11900 0.19590 -0.02240 0.00270  0.00560  1483 GLU A CG  
366  C  CD  . GLU A 24  ? 0.10030 0.11990 0.19270 -0.00710 -0.01050 0.00380  1483 GLU A CD  
367  O  OE1 . GLU A 24  ? 0.10730 0.13000 0.19120 -0.01890 -0.00970 0.00570  1483 GLU A OE1 
368  O  OE2 . GLU A 24  ? 0.09630 0.12660 0.20830 -0.00980 0.00370  -0.00530 1483 GLU A OE2 
375  N  N   . ASP A 25  ? 0.13810 0.12430 0.17420 -0.02440 0.00530  -0.01210 1484 ASP A N   
376  C  CA  . ASP A 25  ? 0.11970 0.12850 0.17310 -0.01730 -0.00920 -0.00160 1484 ASP A CA  
377  C  C   . ASP A 25  ? 0.12360 0.12680 0.15470 -0.02010 -0.01750 -0.00470 1484 ASP A C   
378  O  O   . ASP A 25  ? 0.12950 0.12920 0.17830 -0.01250 0.01050  0.00890  1484 ASP A O   
379  C  CB  . ASP A 25  ? 0.14790 0.13740 0.20980 -0.01570 0.01610  0.00430  1484 ASP A CB  
380  C  CG  . ASP A 25  ? 0.14090 0.14150 0.25370 -0.03120 0.03730  0.00230  1484 ASP A CG  
381  O  OD1 . ASP A 25  ? 0.18650 0.16059 0.30930 -0.06670 0.04550  -0.01170 1484 ASP A OD1 
382  O  OD2 . ASP A 25  ? 0.13530 0.12560 0.22530 -0.03180 -0.00160 -0.00920 1484 ASP A OD2 
387  N  N   . PHE A 26  ? 0.12620 0.12290 0.17580 -0.01820 -0.01310 0.01200  1485 PHE A N   
388  C  CA  . PHE A 26  ? 0.12590 0.12730 0.18010 -0.02080 0.01460  0.01250  1485 PHE A CA  
389  C  C   . PHE A 26  ? 0.12930 0.12000 0.16190 -0.01000 0.01310  0.00280  1485 PHE A C   
390  O  O   . PHE A 26  ? 0.14580 0.11780 0.15580 -0.00800 0.02150  0.00170  1485 PHE A O   
391  C  CB  . PHE A 26  ? 0.16130 0.14110 0.18130 -0.00890 0.01050  0.02480  1485 PHE A CB  
392  C  CG  . PHE A 26  ? 0.17970 0.15760 0.19650 0.00400  -0.01530 0.03430  1485 PHE A CG  
393  C  CD1 . PHE A 26  ? 0.24890 0.17249 0.22430 -0.03320 -0.03390 0.03640  1485 PHE A CD1 
394  C  CD2 . PHE A 26  ? 0.15010 0.17440 0.20630 0.01460  -0.02470 0.00440  1485 PHE A CD2 
395  C  CE1 . PHE A 26  ? 0.27120 0.16960 0.24730 -0.03260 -0.02830 0.01430  1485 PHE A CE1 
396  C  CE2 . PHE A 26  ? 0.17420 0.18569 0.23530 0.02870  -0.00970 -0.01120 1485 PHE A CE2 
397  C  CZ  . PHE A 26  ? 0.25579 0.16850 0.24790 0.00340  -0.03120 -0.01640 1485 PHE A CZ  
407  N  N   . ALA A 27  ? 0.12550 0.11210 0.21250 -0.00200 0.01070  -0.00260 1486 ALA A N   
408  C  CA  . ALA A 27  ? 0.15969 0.12020 0.21540 -0.01490 0.03170  0.00270  1486 ALA A CA  
409  C  C   . ALA A 27  ? 0.13190 0.11840 0.20510 -0.01350 0.00740  -0.01210 1486 ALA A C   
410  O  O   . ALA A 27  ? 0.14720 0.13549 0.21540 -0.01260 0.01310  -0.00650 1486 ALA A O   
411  C  CB  . ALA A 27  ? 0.16020 0.12570 0.24290 -0.03160 0.04320  0.01090  1486 ALA A CB  
417  N  N   . SER A 28  ? 0.12240 0.11380 0.22350 -0.01290 0.00050  -0.01250 1487 SER A N   
418  C  CA  . SER A 28  ? 0.11330 0.12960 0.23700 -0.02600 0.00460  -0.01520 1487 SER A CA  
419  C  C   . SER A 28  ? 0.12020 0.13600 0.19290 -0.01940 0.01810  0.00430  1487 SER A C   
420  O  O   . SER A 28  ? 0.13640 0.13130 0.18120 -0.02340 0.00680  -0.01190 1487 SER A O   
421  C  CB  . SER A 28  ? 0.12040 0.12980 0.24740 -0.03440 0.00160  -0.03160 1487 SER A CB  
422  O  OG  . SER A 28  ? 0.11940 0.12570 0.21470 -0.02660 -0.00400 -0.01400 1487 SER A OG  
428  N  N   . GLY A 29  ? 0.11920 0.13580 0.19710 -0.02750 -0.01230 0.00090  1488 GLY A N   
429  C  CA  . GLY A 29  ? 0.10900 0.13210 0.16380 -0.01760 0.01430  -0.01100 1488 GLY A CA  
430  C  C   . GLY A 29  ? 0.10520 0.12270 0.15230 -0.02380 0.01100  -0.01030 1488 GLY A C   
431  O  O   . GLY A 29  ? 0.10940 0.11230 0.20250 -0.01380 0.02300  -0.02040 1488 GLY A O   
435  N  N   . THR A 30  ? 0.11310 0.11860 0.19340 -0.02280 0.00680  -0.00060 1489 THR A N   
436  C  CA  . THR A 30  ? 0.11500 0.11390 0.19300 -0.03510 0.00690  -0.01570 1489 THR A CA  
437  C  C   . THR A 30  ? 0.12640 0.11880 0.18360 -0.01450 -0.00630 -0.01480 1489 THR A C   
438  O  O   . THR A 30  ? 0.13040 0.11210 0.20040 -0.01550 0.02080  -0.02330 1489 THR A O   
439  C  CB  . THR A 30  ? 0.12480 0.11620 0.20010 -0.03070 0.00340  -0.01400 1489 THR A CB  
440  O  OG1 . THR A 30  ? 0.10670 0.11430 0.22750 -0.01620 0.00790  0.00010  1489 THR A OG1 
441  C  CG2 . THR A 30  ? 0.12130 0.12700 0.22110 -0.02570 0.01280  -0.00090 1489 THR A CG2 
449  N  N   . ALA A 31  ? 0.11700 0.12320 0.21110 -0.01510 0.00470  -0.02520 1490 ALA A N   
450  C  CA  . ALA A 31  ? 0.13480 0.12400 0.20140 -0.02460 0.00280  -0.02990 1490 ALA A CA  
451  C  C   . ALA A 31  ? 0.12900 0.11910 0.18270 -0.03300 0.00390  -0.04580 1490 ALA A C   
452  O  O   . ALA A 31  ? 0.11790 0.12060 0.16020 -0.02490 -0.00070 -0.03450 1490 ALA A O   
453  C  CB  . ALA A 31  ? 0.13490 0.12650 0.21930 -0.03410 0.00520  -0.03690 1490 ALA A CB  
459  N  N   . ALA A 32  ? 0.11380 0.11400 0.22560 -0.03100 -0.00430 -0.03120 1491 ALA A N   
460  C  CA  . ALA A 32  ? 0.11630 0.12240 0.19540 -0.02930 0.00310  -0.03230 1491 ALA A CA  
461  C  C   . ALA A 32  ? 0.10550 0.12010 0.15420 -0.01900 0.01350  -0.02970 1491 ALA A C   
462  O  O   . ALA A 32  ? 0.10450 0.12110 0.16390 -0.01190 0.00300  -0.02340 1491 ALA A O   
463  C  CB  . ALA A 32  ? 0.12010 0.13270 0.16200 -0.01700 0.00670  -0.03380 1491 ALA A CB  
469  N  N   . ALA A 33  ? 0.11340 0.11740 0.16630 -0.01760 -0.00560 -0.02090 1492 ALA A N   
470  C  CA  . ALA A 33  ? 0.09590 0.12290 0.15890 -0.01630 -0.00540 -0.01300 1492 ALA A CA  
471  C  C   . ALA A 33  ? 0.11440 0.11800 0.15020 -0.00800 0.00790  -0.01950 1492 ALA A C   
472  O  O   . ALA A 33  ? 0.12990 0.11450 0.16320 -0.01140 0.02000  -0.02850 1492 ALA A O   
473  C  CB  . ALA A 33  ? 0.10360 0.12910 0.16390 -0.01600 -0.00070 -0.01230 1492 ALA A CB  
479  N  N   . LEU A 34  ? 0.12230 0.11910 0.16280 -0.00360 -0.00640 -0.02820 1493 LEU A N   
480  C  CA  . LEU A 34  ? 0.12510 0.11730 0.17170 -0.01660 0.01910  -0.02860 1493 LEU A CA  
481  C  C   . LEU A 34  ? 0.13460 0.11750 0.16870 -0.02200 0.01270  -0.03440 1493 LEU A C   
482  O  O   . LEU A 34  ? 0.13760 0.11110 0.18070 -0.01390 0.02880  -0.01960 1493 LEU A O   
483  C  CB  . LEU A 34  ? 0.14440 0.11650 0.20310 -0.00680 0.00310  -0.02170 1493 LEU A CB  
484  C  CG  . LEU A 34  ? 0.13840 0.11720 0.19040 -0.00830 0.01340  -0.02810 1493 LEU A CG  
485  C  CD1 . LEU A 34  ? 0.13230 0.11830 0.25290 0.00330  -0.00150 0.01120  1493 LEU A CD1 
486  C  CD2 . LEU A 34  ? 0.14150 0.11890 0.21540 -0.00940 0.01740  -0.04090 1493 LEU A CD2 
498  N  N   . ALA A 35  ? 0.12420 0.13320 0.21570 -0.02590 -0.01560 -0.04140 1494 ALA A N   
499  C  CA  . ALA A 35  ? 0.13590 0.14580 0.21420 -0.01620 0.00390  -0.03090 1494 ALA A CA  
500  C  C   . ALA A 35  ? 0.15060 0.14449 0.18350 -0.01550 -0.00180 -0.04440 1494 ALA A C   
501  O  O   . ALA A 35  ? 0.17900 0.14710 0.22080 -0.03280 0.01670  -0.04360 1494 ALA A O   
502  C  CB  . ALA A 35  ? 0.15280 0.15530 0.20010 -0.03430 0.02310  -0.04160 1494 ALA A CB  
508  N  N   . GLY A 36  ? 0.15080 0.11740 0.17400 -0.00590 -0.00800 -0.03010 1495 GLY A N   
509  C  CA  . GLY A 36  ? 0.15360 0.11960 0.17150 -0.00310 0.01510  -0.01100 1495 GLY A CA  
510  C  C   . GLY A 36  ? 0.15160 0.12330 0.17330 0.00760  0.01610  -0.02080 1495 GLY A C   
511  O  O   . GLY A 36  ? 0.14030 0.12360 0.19840 0.00780  0.01130  -0.02590 1495 GLY A O   
515  N  N   . GLY A 37  ? 0.13170 0.11330 0.18760 -0.00310 -0.00690 -0.03400 1496 GLY A N   
516  C  CA  . GLY A 37  ? 0.12090 0.12549 0.17820 -0.00770 0.01760  -0.02630 1496 GLY A CA  
517  C  C   . GLY A 37  ? 0.10450 0.11480 0.16260 -0.01370 0.01200  -0.02710 1496 GLY A C   
518  O  O   . GLY A 37  ? 0.11920 0.13209 0.20430 -0.01840 0.01580  -0.04300 1496 GLY A O   
522  N  N   . ILE A 38  ? 0.11710 0.11180 0.17190 -0.01560 0.01580  -0.01970 1497 ILE A N   
523  C  CA  . ILE A 38  ? 0.12140 0.11390 0.18240 -0.01390 0.01870  -0.02940 1497 ILE A CA  
524  C  C   . ILE A 38  ? 0.10960 0.10980 0.17770 -0.01180 -0.00250 -0.01530 1497 ILE A C   
525  O  O   . ILE A 38  ? 0.11100 0.10470 0.22090 -0.02080 -0.00840 -0.01350 1497 ILE A O   
526  C  CB  . ILE A 38  ? 0.11990 0.12290 0.13880 -0.01540 0.00010  -0.01550 1497 ILE A CB  
527  C  CG1 . ILE A 38  ? 0.15460 0.14550 0.21800 -0.01750 0.00770  -0.01260 1497 ILE A CG1 
528  C  CG2 . ILE A 38  ? 0.12990 0.10750 0.15840 -0.01240 0.02300  -0.04010 1497 ILE A CG2 
529  C  CD1 . ILE A 38  ? 0.15160 0.16139 0.29930 0.01510  0.03690  -0.00590 1497 ILE A CD1 
541  N  N   . THR A 39  ? 0.10140 0.10290 0.20290 -0.01410 0.00560  -0.02560 1498 THR A N   
542  C  CA  . THR A 39  ? 0.10530 0.10230 0.17220 -0.01430 0.02100  -0.02580 1498 THR A CA  
543  C  C   . THR A 39  ? 0.09150 0.09760 0.17310 -0.01330 0.00870  -0.01020 1498 THR A C   
544  O  O   . THR A 39  ? 0.11180 0.09590 0.16880 -0.00120 0.01550  -0.00510 1498 THR A O   
545  C  CB  . THR A 39  ? 0.12800 0.11990 0.18030 -0.01540 0.02690  -0.01870 1498 THR A CB  
546  O  OG1 . THR A 39  ? 0.11310 0.11540 0.17900 -0.01050 0.02540  -0.00710 1498 THR A OG1 
547  C  CG2 . THR A 39  ? 0.14680 0.13809 0.18100 -0.00040 0.02850  -0.02650 1498 THR A CG2 
555  N  N   . MET A 40  ? 0.11620 0.08390 0.18260 -0.00410 0.01300  0.00160  1499 MET A N   
556  C  CA  . MET A 40  ? 0.09500 0.09240 0.17780 -0.00220 0.01320  0.00250  1499 MET A CA  
557  C  C   . MET A 40  ? 0.10840 0.09280 0.13450 -0.00320 0.00690  -0.00090 1499 MET A C   
558  O  O   . MET A 40  ? 0.10550 0.10030 0.14610 -0.00170 0.01750  -0.00330 1499 MET A O   
559  C  CB  . MET A 40  ? 0.10500 0.09710 0.18040 -0.01440 0.00250  -0.00320 1499 MET A CB  
560  C  CG  . MET A 40  ? 0.10340 0.10010 0.19240 -0.01290 0.00550  -0.02220 1499 MET A CG  
561  S  SD  . MET A 40  ? 0.10809 0.10980 0.20110 -0.00770 -0.00080 -0.01620 1499 MET A SD  
562  C  CE  . MET A 40  ? 0.11050 0.13699 0.22970 -0.00740 0.01080  -0.02490 1499 MET A CE  
572  N  N   . VAL A 41  ? 0.12960 0.09330 0.13480 0.00040  0.00470  -0.01150 1500 VAL A N   
573  C  CA  . VAL A 41  ? 0.12810 0.10280 0.13250 0.00760  0.02520  -0.01080 1500 VAL A CA  
574  C  C   . VAL A 41  ? 0.10850 0.09740 0.15070 -0.00140 0.02890  -0.00480 1500 VAL A C   
575  O  O   . VAL A 41  ? 0.14850 0.09390 0.19030 0.01160  0.00850  -0.00700 1500 VAL A O   
576  C  CB  . VAL A 41  ? 0.10240 0.12680 0.15330 -0.00410 0.00500  -0.00660 1500 VAL A CB  
577  C  CG1 . VAL A 41  ? 0.10580 0.12350 0.14140 -0.00480 0.00160  -0.00110 1500 VAL A CG1 
578  C  CG2 . VAL A 41  ? 0.10560 0.14239 0.21450 -0.01570 0.02190  -0.00310 1500 VAL A CG2 
588  N  N   . CYS A 42  ? 0.10940 0.09320 0.15780 -0.00350 0.02680  0.00630  1501 CYS A N   
589  C  CA  . CYS A 42  ? 0.11180 0.09580 0.14980 0.00500  0.01510  -0.00370 1501 CYS A CA  
590  C  C   . CYS A 42  ? 0.09810 0.10920 0.14710 -0.00150 0.00000  -0.00620 1501 CYS A C   
591  O  O   . CYS A 42  ? 0.09740 0.11430 0.14910 -0.00690 -0.00220 0.00840  1501 CYS A O   
592  C  CB  . CYS A 42  ? 0.08700 0.09950 0.18640 -0.00370 0.02070  0.00700  1501 CYS A CB  
593  S  SG  . CYS A 42  ? 0.09569 0.11459 0.23040 -0.00390 0.01510  0.00580  1501 CYS A SG  
599  N  N   . ALA A 43  ? 0.09140 0.11720 0.14140 -0.00300 -0.00230 0.00850  1502 ALA A N   
600  C  CA  . ALA A 43  ? 0.09010 0.11290 0.18790 -0.00830 0.00030  0.00900  1502 ALA A CA  
601  C  C   . ALA A 43  ? 0.08460 0.11470 0.17660 -0.01440 0.00150  0.01690  1502 ALA A C   
602  O  O   . ALA A 43  ? 0.09920 0.11580 0.16930 -0.00460 -0.00090 -0.00090 1502 ALA A O   
603  C  CB  . ALA A 43  ? 0.11400 0.11850 0.19760 -0.02150 0.00460  -0.00340 1502 ALA A CB  
609  N  N   . MET A 44  ? 0.09660 0.10630 0.16000 -0.00500 0.00320  0.00800  1503 MET A N   
610  C  CA  . MET A 44  ? 0.09640 0.12090 0.11890 -0.01370 -0.00300 0.00580  1503 MET A CA  
611  C  C   . MET A 44  ? 0.10950 0.12309 0.13960 -0.00270 -0.00980 0.00440  1503 MET A C   
612  O  O   . MET A 44  ? 0.12040 0.10570 0.17200 -0.01940 -0.00180 0.00570  1503 MET A O   
613  C  CB  . MET A 44  ? 0.09400 0.13319 0.15080 -0.00010 -0.02350 0.00840  1503 MET A CB  
614  C  CG  . MET A 44  ? 0.10860 0.12420 0.13460 -0.00350 -0.00840 0.00500  1503 MET A CG  
615  S  SD  . MET A 44  ? 0.10629 0.10960 0.16539 -0.00660 -0.00640 0.00240  1503 MET A SD  
616  C  CE  . MET A 44  ? 0.10040 0.13779 0.15210 -0.01330 0.01150  0.03670  1503 MET A CE  
626  N  N   . PRO A 45  ? 0.10810 0.12090 0.13070 -0.01610 -0.00420 0.00720  1504 PRO A N   
627  C  CA  . PRO A 45  ? 0.11320 0.12990 0.12400 -0.01020 -0.01070 0.00680  1504 PRO A CA  
628  C  C   . PRO A 45  ? 0.11950 0.13240 0.11520 -0.01550 -0.01790 0.00020  1504 PRO A C   
629  O  O   . PRO A 45  ? 0.13430 0.13380 0.13240 -0.00130 -0.00360 0.01820  1504 PRO A O   
630  C  CB  . PRO A 45  ? 0.11790 0.12090 0.15490 -0.00540 0.00500  -0.00010 1504 PRO A CB  
631  C  CG  . PRO A 45  ? 0.10960 0.12050 0.15330 -0.00060 0.01810  -0.00190 1504 PRO A CG  
632  C  CD  . PRO A 45  ? 0.11600 0.11970 0.12480 -0.00830 0.01730  0.00810  1504 PRO A CD  
640  N  N   . ASN A 46  ? 0.11740 0.13660 0.13130 -0.01940 -0.00170 0.00540  1505 ASN A N   
641  C  CA  . ASN A 46  ? 0.10560 0.14520 0.16150 -0.02140 0.01040  -0.00180 1505 ASN A CA  
642  C  C   . ASN A 46  ? 0.10720 0.14220 0.17940 -0.01360 0.01000  -0.01660 1505 ASN A C   
643  O  O   . ASN A 46  ? 0.11670 0.15839 0.16580 -0.02090 0.00850  -0.00620 1505 ASN A O   
644  C  CB  . ASN A 46  ? 0.12830 0.15030 0.14300 -0.01420 -0.00600 0.00630  1505 ASN A CB  
645  C  CG  . ASN A 46  ? 0.10700 0.15450 0.13130 -0.01430 -0.00570 0.02190  1505 ASN A CG  
646  O  OD1 . ASN A 46  ? 0.14450 0.13110 0.15170 -0.01500 0.00520  0.00670  1505 ASN A OD1 
647  N  ND2 . ASN A 46  ? 0.09700 0.17559 0.16450 -0.00050 0.00290  0.04460  1505 ASN A ND2 
654  N  N   . THR A 47  ? 0.12110 0.13700 0.18350 -0.02530 0.00620  0.01130  1506 THR A N   
655  C  CA  . THR A 47  ? 0.13110 0.15210 0.15100 -0.03080 0.00160  0.02270  1506 THR A CA  
656  C  C   . THR A 47  ? 0.13300 0.18270 0.15220 -0.04040 -0.00110 0.00210  1506 THR A C   
657  O  O   . THR A 47  ? 0.14360 0.19560 0.17820 -0.02980 0.01690  -0.01720 1506 THR A O   
658  C  CB  . THR A 47  ? 0.16070 0.14170 0.17040 -0.02210 -0.02210 0.02130  1506 THR A CB  
659  O  OG1 . THR A 47  ? 0.15620 0.12980 0.20920 -0.02300 -0.00600 0.02430  1506 THR A OG1 
660  C  CG2 . THR A 47  ? 0.15900 0.14310 0.19730 -0.01980 -0.01140 0.02460  1506 THR A CG2 
668  N  N   . ARG A 48  ? 0.14550 0.20330 0.18970 -0.05770 0.01570  0.00680  1507 ARG A N   
669  C  CA  . ARG A 48  ? 0.17650 0.24170 0.23170 -0.05680 0.01900  0.00220  1507 ARG A CA  
670  C  C   . ARG A 48  ? 0.21080 0.24390 0.19280 -0.08340 0.01500  0.03530  1507 ARG A C   
671  O  O   . ARG A 48  ? 0.25460 0.23480 0.22110 -0.09090 0.00610  0.03600  1507 ARG A O   
672  C  CB  . ARG A 48  ? 0.19070 0.26949 0.27450 -0.05130 0.04460  -0.00170 1507 ARG A CB  
675  N  N   . PRO A 49  ? 0.23870 0.23920 0.21000 -0.08680 -0.00240 0.03010  1508 PRO A N   
676  C  CA  . PRO A 49  ? 0.22520 0.23900 0.20010 -0.08110 0.00110  0.04310  1508 PRO A CA  
677  C  C   . PRO A 49  ? 0.18730 0.22210 0.18410 -0.05070 0.03870  0.00920  1508 PRO A C   
678  O  O   . PRO A 49  ? 0.20240 0.21080 0.16280 -0.04830 0.01210  0.01580  1508 PRO A O   
679  C  CB  . PRO A 49  ? 0.28449 0.25150 0.21290 -0.07550 -0.00880 0.05350  1508 PRO A CB  
680  C  CG  . PRO A 49  ? 0.28180 0.26089 0.24090 -0.07230 -0.01600 0.03770  1508 PRO A CG  
681  C  CD  . PRO A 49  ? 0.27420 0.25200 0.24540 -0.08950 -0.02890 0.04290  1508 PRO A CD  
689  N  N   . PRO A 50  ? 0.15660 0.20920 0.20200 -0.03260 0.00580  0.00330  1509 PRO A N   
690  C  CA  . PRO A 50  ? 0.13950 0.19540 0.15680 -0.01670 0.00640  0.00940  1509 PRO A CA  
691  C  C   . PRO A 50  ? 0.15360 0.17680 0.13970 -0.02390 0.02890  0.01070  1509 PRO A C   
692  O  O   . PRO A 50  ? 0.17210 0.17860 0.14600 -0.02930 0.01570  0.01840  1509 PRO A O   
693  C  CB  . PRO A 50  ? 0.15110 0.20840 0.21240 -0.00320 -0.01270 0.00160  1509 PRO A CB  
694  C  CG  . PRO A 50  ? 0.18979 0.21650 0.24000 -0.02410 0.01040  -0.00750 1509 PRO A CG  
695  C  CD  . PRO A 50  ? 0.16360 0.21610 0.22500 -0.03820 0.02820  -0.00290 1509 PRO A CD  
703  N  N   . ILE A 51  ? 0.13620 0.16720 0.14430 -0.02630 0.00050  0.02690  1510 ILE A N   
704  C  CA  . ILE A 51  ? 0.14270 0.15480 0.15250 -0.02250 -0.00050 0.02580  1510 ILE A CA  
705  C  C   . ILE A 51  ? 0.15000 0.14370 0.16160 -0.01910 -0.00320 0.02710  1510 ILE A C   
706  O  O   . ILE A 51  ? 0.15780 0.14190 0.18750 -0.02460 -0.00600 0.04730  1510 ILE A O   
707  C  CB  . ILE A 51  ? 0.15480 0.14530 0.14840 -0.01710 0.00260  0.04280  1510 ILE A CB  
708  C  CG1 . ILE A 51  ? 0.17360 0.14660 0.21300 -0.01890 -0.00870 0.02310  1510 ILE A CG1 
709  C  CG2 . ILE A 51  ? 0.16980 0.14350 0.16860 -0.00860 0.01210  0.03920  1510 ILE A CG2 
710  C  CD1 . ILE A 51  ? 0.19160 0.13900 0.19220 0.00130  -0.00480 0.01510  1510 ILE A CD1 
722  N  N   . ILE A 52  ? 0.16310 0.15340 0.19720 -0.04170 -0.00210 0.01310  1511 ILE A N   
723  C  CA  . ILE A 52  ? 0.18990 0.16080 0.17430 -0.04080 -0.00070 0.00980  1511 ILE A CA  
724  C  C   . ILE A 52  ? 0.19940 0.15530 0.18220 -0.06210 -0.00730 0.00570  1511 ILE A C   
725  O  O   . ILE A 52  ? 0.22870 0.14030 0.18240 -0.05510 -0.00610 -0.00420 1511 ILE A O   
726  C  CB  . ILE A 52  ? 0.18000 0.18720 0.19390 -0.04370 -0.00370 -0.02050 1511 ILE A CB  
727  C  CG1 . ILE A 52  ? 0.21260 0.20430 0.22370 -0.03290 -0.00720 -0.02990 1511 ILE A CG1 
728  C  CG2 . ILE A 52  ? 0.18180 0.19660 0.24380 -0.02840 -0.02940 0.00290  1511 ILE A CG2 
729  C  CD1 . ILE A 52  ? 0.22080 0.22039 0.25860 -0.04050 -0.00730 -0.04400 1511 ILE A CD1 
741  N  N   A ASP A 53  ? 0.20680 0.15990 0.17850 -0.05990 -0.00130 0.02100  1512 ASP A N   
742  N  N   B ASP A 53  ? 0.20350 0.15730 0.16150 -0.06110 0.00970  0.02510  1512 ASP A N   
743  C  CA  A ASP A 53  ? 0.22580 0.16700 0.18390 -0.05270 -0.00970 0.03680  1512 ASP A CA  
744  C  CA  B ASP A 53  ? 0.23560 0.16720 0.15970 -0.04670 -0.00280 0.03800  1512 ASP A CA  
745  C  C   A ASP A 53  ? 0.22520 0.16880 0.18930 -0.04380 -0.00760 0.04630  1512 ASP A C   
746  C  C   B ASP A 53  ? 0.22780 0.16540 0.16540 -0.04250 -0.00470 0.05830  1512 ASP A C   
747  O  O   A ASP A 53  ? 0.21990 0.16790 0.19900 -0.03810 -0.00430 0.03530  1512 ASP A O   
748  O  O   B ASP A 53  ? 0.21850 0.16160 0.18990 -0.03820 -0.01250 0.04150  1512 ASP A O   
749  C  CB  A ASP A 53  ? 0.23730 0.16970 0.19330 -0.06040 -0.01040 0.04170  1512 ASP A CB  
750  C  CB  B ASP A 53  ? 0.26660 0.17510 0.18640 -0.04070 -0.00220 0.02210  1512 ASP A CB  
751  C  CG  A ASP A 53  ? 0.23650 0.17620 0.21200 -0.06560 -0.00340 0.05030  1512 ASP A CG  
752  C  CG  B ASP A 53  ? 0.26780 0.18149 0.23930 -0.01980 0.01170  0.03040  1512 ASP A CG  
753  O  OD1 A ASP A 53  ? 0.25780 0.16150 0.22050 -0.06830 0.01090  0.04040  1512 ASP A OD1 
754  O  OD1 B ASP A 53  ? 0.26160 0.15620 0.20140 -0.01800 0.01880  0.05680  1512 ASP A OD1 
755  O  OD2 A ASP A 53  ? 0.21020 0.19070 0.22500 -0.07210 -0.00620 0.05000  1512 ASP A OD2 
756  O  OD2 B ASP A 53  ? 0.25650 0.19430 0.28630 -0.02200 -0.00370 0.01690  1512 ASP A OD2 
765  N  N   . ALA A 54  ? 0.23520 0.17350 0.21210 -0.04380 -0.01950 0.04790  1513 ALA A N   
766  C  CA  . ALA A 54  ? 0.22010 0.17930 0.20890 -0.03710 -0.01600 0.04870  1513 ALA A CA  
767  C  C   . ALA A 54  ? 0.21910 0.16710 0.21620 -0.02710 -0.01790 0.05560  1513 ALA A C   
768  O  O   . ALA A 54  ? 0.21000 0.16780 0.24050 -0.03180 -0.00510 0.06260  1513 ALA A O   
769  C  CB  . ALA A 54  ? 0.24790 0.18450 0.20310 -0.02610 -0.00450 0.02270  1513 ALA A CB  
775  N  N   . PRO A 55  ? 0.22910 0.16110 0.18320 -0.02990 -0.00450 0.04100  1514 PRO A N   
776  C  CA  . PRO A 55  ? 0.23040 0.16120 0.19210 -0.02860 0.03820  0.02140  1514 PRO A CA  
777  C  C   . PRO A 55  ? 0.21410 0.14720 0.19070 -0.03220 0.03700  0.02910  1514 PRO A C   
778  O  O   . PRO A 55  ? 0.20150 0.14260 0.19080 -0.03980 0.01530  0.02850  1514 PRO A O   
779  C  CB  . PRO A 55  ? 0.25840 0.17190 0.16140 -0.02820 0.03780  0.02240  1514 PRO A CB  
780  C  CG  . PRO A 55  ? 0.27330 0.17290 0.22989 -0.03210 0.04160  0.01590  1514 PRO A CG  
781  C  CD  . PRO A 55  ? 0.26450 0.16570 0.17710 -0.03530 0.01640  0.03740  1514 PRO A CD  
789  N  N   . ALA A 56  ? 0.20970 0.13870 0.16580 -0.02820 0.03860  0.02640  1515 ALA A N   
790  C  CA  . ALA A 56  ? 0.19280 0.14730 0.17860 -0.02970 0.01990  0.02400  1515 ALA A CA  
791  C  C   . ALA A 56  ? 0.17790 0.14030 0.18170 -0.02560 0.01270  0.03630  1515 ALA A C   
792  O  O   . ALA A 56  ? 0.16390 0.14050 0.21370 -0.01420 0.01270  0.04380  1515 ALA A O   
793  C  CB  . ALA A 56  ? 0.20360 0.15800 0.18930 -0.01810 0.00680  0.01220  1515 ALA A CB  
799  N  N   . LEU A 57  ? 0.17830 0.14310 0.18890 -0.03490 0.00490  0.03720  1516 LEU A N   
800  C  CA  . LEU A 57  ? 0.18560 0.14040 0.19840 -0.03700 0.01730  0.02660  1516 LEU A CA  
801  C  C   . LEU A 57  ? 0.17310 0.13260 0.20930 -0.03570 0.03380  0.02000  1516 LEU A C   
802  O  O   . LEU A 57  ? 0.17590 0.12960 0.19900 -0.02770 0.02520  0.02170  1516 LEU A O   
803  C  CB  . LEU A 57  ? 0.18220 0.16670 0.19640 -0.03840 0.01340  0.04410  1516 LEU A CB  
804  C  CG  . LEU A 57  ? 0.18650 0.18130 0.21410 -0.03890 0.02140  0.03410  1516 LEU A CG  
805  C  CD1 . LEU A 57  ? 0.20540 0.17870 0.23680 -0.05700 0.01140  0.03800  1516 LEU A CD1 
806  C  CD2 . LEU A 57  ? 0.17920 0.19799 0.23590 -0.04880 0.03600  0.01790  1516 LEU A CD2 
818  N  N   . ALA A 58  ? 0.17470 0.12840 0.22680 -0.03380 0.03670  0.02170  1517 ALA A N   
819  C  CA  . ALA A 58  ? 0.18330 0.13430 0.22410 -0.02500 0.00330  0.02070  1517 ALA A CA  
820  C  C   . ALA A 58  ? 0.16800 0.13380 0.18200 -0.02400 0.02530  0.02250  1517 ALA A C   
821  O  O   . ALA A 58  ? 0.18330 0.13160 0.18230 -0.02650 0.01880  0.01880  1517 ALA A O   
822  C  CB  . ALA A 58  ? 0.22680 0.13410 0.22930 -0.02470 -0.02260 0.01470  1517 ALA A CB  
828  N  N   . LEU A 59  ? 0.17170 0.12880 0.19120 -0.02670 0.02040  0.03980  1518 LEU A N   
829  C  CA  . LEU A 59  ? 0.16150 0.13360 0.19920 -0.02970 0.00480  0.03130  1518 LEU A CA  
830  C  C   . LEU A 59  ? 0.14560 0.13590 0.20980 -0.02350 0.01780  0.03730  1518 LEU A C   
831  O  O   . LEU A 59  ? 0.15830 0.12600 0.22640 -0.02870 0.01590  0.04070  1518 LEU A O   
832  C  CB  . LEU A 59  ? 0.17760 0.14980 0.20660 -0.02010 0.02670  0.02740  1518 LEU A CB  
833  C  CG  . LEU A 59  ? 0.17900 0.16860 0.23610 -0.01270 0.02500  0.00760  1518 LEU A CG  
834  C  CD1 . LEU A 59  ? 0.20380 0.16600 0.24990 -0.01490 0.02050  0.01870  1518 LEU A CD1 
835  C  CD2 . LEU A 59  ? 0.17830 0.19179 0.27850 0.00200  0.03140  -0.00650 1518 LEU A CD2 
847  N  N   . ALA A 60  ? 0.16680 0.13610 0.19150 -0.02090 0.03560  0.04820  1519 ALA A N   
848  C  CA  . ALA A 60  ? 0.20250 0.12820 0.16540 -0.02910 0.01630  0.03720  1519 ALA A CA  
849  C  C   . ALA A 60  ? 0.17040 0.13130 0.17060 -0.02990 0.02810  0.04010  1519 ALA A C   
850  O  O   . ALA A 60  ? 0.17620 0.12680 0.19550 -0.01240 0.01600  0.05290  1519 ALA A O   
851  C  CB  . ALA A 60  ? 0.23800 0.14220 0.17650 -0.02430 0.00050  0.03940  1519 ALA A CB  
857  N  N   . GLN A 61  ? 0.16330 0.14050 0.17770 -0.02560 0.02250  0.02440  1520 GLN A N   
858  C  CA  . GLN A 61  ? 0.15860 0.15070 0.18950 -0.03500 0.03500  0.04180  1520 GLN A CA  
859  C  C   . GLN A 61  ? 0.15010 0.14509 0.16880 -0.01610 0.04120  0.02910  1520 GLN A C   
860  O  O   . GLN A 61  ? 0.14500 0.13140 0.18640 -0.01710 0.02650  0.04000  1520 GLN A O   
861  C  CB  . GLN A 61  ? 0.17980 0.16990 0.22350 -0.04990 -0.00510 0.04380  1520 GLN A CB  
862  C  CG  . GLN A 61  ? 0.20700 0.20070 0.23890 -0.03790 0.00180  0.05540  1520 GLN A CG  
863  C  CD  . GLN A 61  ? 0.21210 0.24370 0.31650 -0.04560 -0.01760 0.07840  1520 GLN A CD  
864  O  OE1 . GLN A 61  ? 0.25540 0.26569 0.34650 -0.06000 -0.02500 0.06180  1520 GLN A OE1 
865  N  NE2 . GLN A 61  ? 0.22670 0.27159 0.35860 -0.03250 -0.01260 0.07770  1520 GLN A NE2 
874  N  N   . LYS A 62  ? 0.14400 0.12910 0.21020 -0.02000 0.00920  0.02880  1521 LYS A N   
875  C  CA  . LYS A 62  ? 0.14340 0.12280 0.21070 -0.01510 0.02290  0.02900  1521 LYS A CA  
876  C  C   . LYS A 62  ? 0.14940 0.11430 0.20750 -0.01850 0.02100  0.03270  1521 LYS A C   
877  O  O   . LYS A 62  ? 0.16530 0.11100 0.22180 -0.02380 0.01690  0.02560  1521 LYS A O   
878  C  CB  . LYS A 62  ? 0.18250 0.13630 0.24650 -0.02620 0.01750  0.04430  1521 LYS A CB  
879  C  CG  . LYS A 62  ? 0.19610 0.17290 0.25030 -0.00960 0.02880  0.08280  1521 LYS A CG  
880  C  CD  . LYS A 62  ? 0.18810 0.22319 0.25980 0.02900  0.04290  0.09480  1521 LYS A CD  
881  C  CE  . LYS A 62  ? 0.26249 0.22030 0.32630 0.00670  0.07720  0.05640  1521 LYS A CE  
882  N  NZ  . LYS A 62  ? 0.26440 0.22770 0.36450 -0.01740 0.11010  0.00250  1521 LYS A NZ  
896  N  N   . LEU A 63  ? 0.13640 0.11560 0.22700 -0.01070 0.03510  0.05410  1522 LEU A N   
897  C  CA  . LEU A 63  ? 0.13670 0.12190 0.20880 -0.01750 0.01730  0.02910  1522 LEU A CA  
898  C  C   . LEU A 63  ? 0.11760 0.11920 0.24300 -0.01500 -0.00420 0.02380  1522 LEU A C   
899  O  O   . LEU A 63  ? 0.12080 0.12020 0.25040 -0.01760 0.02280  0.01590  1522 LEU A O   
900  C  CB  . LEU A 63  ? 0.14480 0.15220 0.18350 -0.00010 0.01710  0.04260  1522 LEU A CB  
901  C  CG  . LEU A 63  ? 0.15940 0.18190 0.23070 0.00910  0.03310  0.04550  1522 LEU A CG  
902  C  CD1 . LEU A 63  ? 0.20460 0.19560 0.23830 0.02380  0.02160  0.02720  1522 LEU A CD1 
903  C  CD2 . LEU A 63  ? 0.17470 0.19470 0.23730 -0.00170 0.05160  0.03990  1522 LEU A CD2 
915  N  N   . ALA A 64  ? 0.11900 0.11830 0.20720 -0.01470 0.00970  0.01220  1523 ALA A N   
916  C  CA  . ALA A 64  ? 0.13960 0.12160 0.19910 -0.02060 0.01840  0.01850  1523 ALA A CA  
917  C  C   . ALA A 64  ? 0.12060 0.12270 0.19790 -0.02270 0.01590  0.02670  1523 ALA A C   
918  O  O   . ALA A 64  ? 0.13170 0.12720 0.21100 -0.01880 0.02000  0.00460  1523 ALA A O   
919  C  CB  . ALA A 64  ? 0.14890 0.12580 0.16720 -0.01940 0.02300  0.03910  1523 ALA A CB  
925  N  N   . GLU A 65  ? 0.12900 0.12980 0.20590 -0.01850 0.01460  0.00870  1524 GLU A N   
926  C  CA  . GLU A 65  ? 0.13490 0.12940 0.27050 -0.00360 -0.00640 0.00300  1524 GLU A CA  
927  C  C   . GLU A 65  ? 0.13960 0.13370 0.28580 -0.01220 -0.01240 -0.01730 1524 GLU A C   
928  O  O   . GLU A 65  ? 0.17050 0.14830 0.28840 0.00590  -0.00310 -0.03080 1524 GLU A O   
929  C  CB  . GLU A 65  ? 0.12640 0.13340 0.24050 -0.00590 0.01010  0.02120  1524 GLU A CB  
930  C  CG  . GLU A 65  ? 0.12510 0.14810 0.24610 -0.01690 0.00170  0.01980  1524 GLU A CG  
931  C  CD  . GLU A 65  ? 0.15370 0.18490 0.26080 -0.03870 -0.01760 0.03840  1524 GLU A CD  
932  O  OE1 . GLU A 65  ? 0.20080 0.24119 0.28360 -0.05390 -0.02080 0.08600  1524 GLU A OE1 
933  O  OE2 . GLU A 65  ? 0.15640 0.17270 0.26960 -0.02800 -0.02000 0.03300  1524 GLU A OE2 
940  N  N   . ALA A 66  ? 0.14630 0.11900 0.27220 -0.02740 0.02000  0.00950  1525 ALA A N   
941  C  CA  . ALA A 66  ? 0.17100 0.11870 0.24030 -0.02840 -0.00710 0.01480  1525 ALA A CA  
942  C  C   . ALA A 66  ? 0.15860 0.12290 0.26280 -0.02330 0.01170  0.02720  1525 ALA A C   
943  O  O   . ALA A 66  ? 0.15470 0.12990 0.25010 -0.01570 0.00640  0.01470  1525 ALA A O   
944  C  CB  . ALA A 66  ? 0.18250 0.12690 0.23460 -0.02580 -0.03570 0.00730  1525 ALA A CB  
950  N  N   . GLY A 67  ? 0.14400 0.11230 0.25340 -0.02340 0.02860  0.01570  1526 GLY A N   
951  C  CA  . GLY A 67  ? 0.13820 0.12200 0.21730 -0.01510 0.01760  -0.00570 1526 GLY A CA  
952  C  C   . GLY A 67  ? 0.13170 0.12020 0.19730 -0.01560 0.01180  -0.00900 1526 GLY A C   
953  O  O   . GLY A 67  ? 0.13230 0.12100 0.22280 -0.02290 0.00460  0.00310  1526 GLY A O   
957  N  N   . ALA A 68  ? 0.14180 0.11200 0.18900 -0.01870 0.00430  -0.00520 1527 ALA A N   
958  C  CA  . ALA A 68  ? 0.14170 0.11900 0.20780 -0.02940 0.00120  0.00010  1527 ALA A CA  
959  C  C   . ALA A 68  ? 0.12770 0.11490 0.22420 -0.02420 0.03500  0.00850  1527 ALA A C   
960  O  O   . ALA A 68  ? 0.14560 0.10480 0.24890 -0.01630 0.02110  0.02610  1527 ALA A O   
961  C  CB  . ALA A 68  ? 0.14610 0.12090 0.17370 -0.03570 0.02200  -0.01790 1527 ALA A CB  
967  N  N   . ARG A 69  ? 0.12290 0.11200 0.20830 -0.01500 0.00780  -0.00340 1528 ARG A N   
968  C  CA  . ARG A 69  ? 0.13320 0.11450 0.21650 -0.01100 0.02360  -0.00070 1528 ARG A CA  
969  C  C   . ARG A 69  ? 0.13990 0.11080 0.20000 -0.01710 0.02300  -0.03420 1528 ARG A C   
970  O  O   . ARG A 69  ? 0.14570 0.12020 0.21330 -0.03490 0.02760  -0.03940 1528 ARG A O   
971  C  CB  . ARG A 69  ? 0.13790 0.11370 0.24750 -0.02100 0.02770  0.00860  1528 ARG A CB  
972  C  CG  . ARG A 69  ? 0.14180 0.11540 0.26630 -0.03300 0.02290  -0.01920 1528 ARG A CG  
973  C  CD  . ARG A 69  ? 0.13070 0.14179 0.27270 -0.02900 0.00780  -0.02490 1528 ARG A CD  
974  N  NE  . ARG A 69  ? 0.13750 0.15020 0.25860 -0.02680 0.01670  -0.03680 1528 ARG A NE  
975  C  CZ  . ARG A 69  ? 0.14900 0.16800 0.25680 -0.04110 0.01760  -0.03730 1528 ARG A CZ  
976  N  NH1 . ARG A 69  ? 0.17840 0.17650 0.28640 -0.03700 0.04760  -0.04380 1528 ARG A NH1 
977  N  NH2 . ARG A 69  ? 0.15640 0.18969 0.25950 -0.04650 0.02350  -0.03200 1528 ARG A NH2 
991  N  N   . CYS A 70  ? 0.11420 0.09130 0.21660 -0.02180 0.01060  -0.01560 1529 CYS A N   
992  C  CA  . CYS A 70  ? 0.12170 0.10790 0.21620 -0.02440 0.02820  -0.00430 1529 CYS A CA  
993  C  C   . CYS A 70  ? 0.11320 0.10130 0.21410 -0.01120 0.02730  -0.00610 1529 CYS A C   
994  O  O   . CYS A 70  ? 0.11170 0.10200 0.21620 -0.01230 0.01350  -0.00870 1529 CYS A O   
995  C  CB  . CYS A 70  ? 0.13920 0.11949 0.21730 -0.01790 0.02000  0.00660  1529 CYS A CB  
996  S  SG  . CYS A 70  ? 0.12270 0.10790 0.24110 -0.01160 -0.00510 -0.01400 1529 CYS A SG  
1002 N  N   . ASP A 71  ? 0.11040 0.09890 0.19070 -0.01400 0.02860  -0.01490 1530 ASP A N   
1003 C  CA  . ASP A 71  ? 0.11920 0.08990 0.18400 -0.02470 0.02690  -0.00630 1530 ASP A CA  
1004 C  C   . ASP A 71  ? 0.13819 0.09440 0.15570 -0.02810 0.03090  0.01390  1530 ASP A C   
1005 O  O   . ASP A 71  ? 0.11150 0.09510 0.18590 -0.01820 0.00720  0.00130  1530 ASP A O   
1006 C  CB  . ASP A 71  ? 0.11180 0.09330 0.22950 -0.00710 0.01530  -0.00610 1530 ASP A CB  
1007 C  CG  . ASP A 71  ? 0.12040 0.09700 0.20650 -0.01160 0.04570  0.01090  1530 ASP A CG  
1008 O  OD1 . ASP A 71  ? 0.13520 0.09970 0.22710 -0.00710 0.03780  0.00460  1530 ASP A OD1 
1009 O  OD2 . ASP A 71  ? 0.12110 0.09290 0.20290 0.00070  0.02570  0.00160  1530 ASP A OD2 
1014 N  N   . PHE A 72  ? 0.11630 0.09900 0.16050 -0.00350 0.03860  0.00090  1531 PHE A N   
1015 C  CA  . PHE A 72  ? 0.12720 0.10080 0.15290 -0.00540 0.01830  -0.00960 1531 PHE A CA  
1016 C  C   . PHE A 72  ? 0.14299 0.10100 0.17800 -0.00240 0.00120  0.00070  1531 PHE A C   
1017 O  O   . PHE A 72  ? 0.11680 0.09090 0.20580 -0.01230 -0.00300 0.01600  1531 PHE A O   
1018 C  CB  . PHE A 72  ? 0.11440 0.10790 0.17860 -0.00410 0.00690  -0.00300 1531 PHE A CB  
1019 C  CG  . PHE A 72  ? 0.12280 0.10080 0.15800 -0.01710 0.01090  0.00710  1531 PHE A CG  
1020 C  CD1 . PHE A 72  ? 0.12690 0.10240 0.16500 -0.02110 0.01600  0.01000  1531 PHE A CD1 
1021 C  CD2 . PHE A 72  ? 0.12570 0.11540 0.16340 -0.03110 0.02690  -0.00540 1531 PHE A CD2 
1022 C  CE1 . PHE A 72  ? 0.15250 0.11890 0.18340 -0.03070 0.02420  0.01220  1531 PHE A CE1 
1023 C  CE2 . PHE A 72  ? 0.13060 0.12310 0.14890 -0.02710 0.03060  0.01180  1531 PHE A CE2 
1024 C  CZ  . PHE A 72  ? 0.13710 0.12470 0.16830 -0.02830 0.01150  0.02290  1531 PHE A CZ  
1034 N  N   . ALA A 73  ? 0.11390 0.10080 0.17360 -0.00100 -0.00300 0.00040  1532 ALA A N   
1035 C  CA  . ALA A 73  ? 0.11650 0.10860 0.19830 -0.00700 0.00740  -0.00520 1532 ALA A CA  
1036 C  C   . ALA A 73  ? 0.12250 0.09740 0.17660 -0.00370 -0.00250 0.00400  1532 ALA A C   
1037 O  O   . ALA A 73  ? 0.12650 0.10180 0.14390 0.00290  0.01120  0.00340  1532 ALA A O   
1038 C  CB  . ALA A 73  ? 0.11290 0.12739 0.20330 -0.00330 0.01100  -0.00920 1532 ALA A CB  
1044 N  N   . LEU A 74  ? 0.10450 0.09830 0.16350 0.00200  0.00590  0.00430  1533 LEU A N   
1045 C  CA  . LEU A 74  ? 0.12080 0.10840 0.13440 -0.01140 0.02450  0.02200  1533 LEU A CA  
1046 C  C   . LEU A 74  ? 0.13710 0.10470 0.12210 -0.01070 -0.00280 0.02690  1533 LEU A C   
1047 O  O   . LEU A 74  ? 0.13430 0.10350 0.16970 -0.00150 -0.03010 0.00980  1533 LEU A O   
1048 C  CB  . LEU A 74  ? 0.15450 0.10890 0.13680 -0.01620 0.00210  0.01550  1533 LEU A CB  
1049 C  CG  . LEU A 74  ? 0.19250 0.11880 0.15640 -0.03090 -0.01050 0.02550  1533 LEU A CG  
1050 C  CD1 . LEU A 74  ? 0.25549 0.14809 0.21920 -0.04790 -0.03070 0.03250  1533 LEU A CD1 
1051 C  CD2 . LEU A 74  ? 0.17040 0.12510 0.16780 -0.03020 0.01200  0.01710  1533 LEU A CD2 
1063 N  N   . PHE A 75  ? 0.11880 0.10170 0.13240 -0.01070 -0.00330 0.02770  1534 PHE A N   
1064 C  CA  . PHE A 75  ? 0.12300 0.11090 0.14210 -0.01290 -0.00010 0.02260  1534 PHE A CA  
1065 C  C   . PHE A 75  ? 0.11610 0.11120 0.14770 -0.01020 -0.02960 0.01490  1534 PHE A C   
1066 O  O   . PHE A 75  ? 0.11850 0.12090 0.17090 -0.01910 -0.00400 0.01270  1534 PHE A O   
1067 C  CB  . PHE A 75  ? 0.14130 0.11200 0.04620 -0.00100 -0.01070 0.01730  1534 PHE A CB  
1068 C  CG  . PHE A 75  ? 0.13660 0.10750 0.04910 0.01930  0.01450  0.02630  1534 PHE A CG  
1069 C  CD1 . PHE A 75  ? 0.12840 0.11920 0.12400 -0.00180 0.00000  0.02120  1534 PHE A CD1 
1070 C  CD2 . PHE A 75  ? 0.12870 0.11240 0.08360 0.01310  0.02050  0.01600  1534 PHE A CD2 
1071 C  CE1 . PHE A 75  ? 0.16010 0.12809 0.14730 0.00170  0.01490  0.03330  1534 PHE A CE1 
1072 C  CE2 . PHE A 75  ? 0.16030 0.11440 0.09500 0.02670  0.01990  0.01190  1534 PHE A CE2 
1073 C  CZ  . PHE A 75  ? 0.15650 0.11710 0.13710 0.01320  0.04630  0.02400  1534 PHE A CZ  
1083 N  N   . LEU A 76  ? 0.09830 0.11410 0.18500 -0.00420 -0.01090 0.01660  1535 LEU A N   
1084 C  CA  . LEU A 76  ? 0.11920 0.11580 0.15960 0.00100  -0.00950 0.02380  1535 LEU A CA  
1085 C  C   . LEU A 76  ? 0.12050 0.11640 0.15800 -0.00220 0.00520  0.01900  1535 LEU A C   
1086 O  O   . LEU A 76  ? 0.12680 0.11350 0.15900 0.00500  0.01410  0.02750  1535 LEU A O   
1087 C  CB  . LEU A 76  ? 0.13740 0.11350 0.15370 -0.01160 -0.00340 0.02950  1535 LEU A CB  
1088 C  CG  . LEU A 76  ? 0.15130 0.11530 0.19250 -0.02320 -0.01920 0.03670  1535 LEU A CG  
1089 C  CD1 . LEU A 76  ? 0.15210 0.13519 0.17890 -0.00250 -0.02580 0.02400  1535 LEU A CD1 
1090 C  CD2 . LEU A 76  ? 0.17940 0.12380 0.23010 -0.03460 -0.01250 0.03080  1535 LEU A CD2 
1102 N  N   . GLY A 77  ? 0.12850 0.11420 0.16050 -0.01220 0.00870  0.01520  1536 GLY A N   
1103 C  CA  . GLY A 77  ? 0.13710 0.12600 0.13200 -0.00110 -0.00150 0.00880  1536 GLY A CA  
1104 C  C   . GLY A 77  ? 0.12720 0.12900 0.12850 -0.00890 0.02310  0.01640  1536 GLY A C   
1105 O  O   . GLY A 77  ? 0.16310 0.13420 0.11420 -0.00800 0.00680  0.00830  1536 GLY A O   
1109 N  N   . ALA A 78  ? 0.13050 0.11250 0.15230 -0.01870 0.02020  0.01450  1537 ALA A N   
1110 C  CA  . ALA A 78  ? 0.14180 0.12390 0.15290 -0.00910 0.00600  0.01370  1537 ALA A CA  
1111 C  C   . ALA A 78  ? 0.15760 0.13830 0.15660 -0.00320 0.01490  0.01250  1537 ALA A C   
1112 O  O   . ALA A 78  ? 0.15680 0.16089 0.16640 -0.00000 -0.00220 0.01380  1537 ALA A O   
1113 C  CB  . ALA A 78  ? 0.14740 0.12020 0.17130 -0.01680 0.01080  0.01120  1537 ALA A CB  
1119 N  N   . ALA A 79  ? 0.14140 0.14360 0.14860 -0.01540 0.02500  -0.00130 1538 ALA A N   
1120 C  CA  . ALA A 79  ? 0.17570 0.17560 0.14810 -0.02030 0.03680  -0.00040 1538 ALA A CA  
1121 C  C   . ALA A 79  ? 0.19080 0.18600 0.14700 -0.02050 0.06010  -0.00970 1538 ALA A C   
1122 O  O   . ALA A 79  ? 0.18320 0.17780 0.17450 -0.02120 0.04990  -0.00190 1538 ALA A O   
1123 C  CB  . ALA A 79  ? 0.19850 0.19119 0.26879 -0.05370 0.05920  0.01090  1538 ALA A CB  
1129 N  N   . SER A 80  ? 0.21700 0.21690 0.21640 -0.00310 0.08800  -0.00910 1539 SER A N   
1130 C  CA  . SER A 80  ? 0.24640 0.24650 0.23480 0.01680  0.10310  -0.01640 1539 SER A CA  
1131 C  C   . SER A 80  ? 0.27830 0.25760 0.24880 -0.00300 0.09020  -0.01580 1539 SER A C   
1132 O  O   . SER A 80  ? 0.34879 0.27010 0.27180 -0.00830 0.09030  -0.03870 1539 SER A O   
1133 C  CB  . SER A 80  ? 0.27630 0.27020 0.32320 0.02600  0.09170  -0.02100 1539 SER A CB  
1134 O  OG  . SER A 80  ? 0.29750 0.29019 0.37390 0.03700  0.12100  -0.00480 1539 SER A OG  
1140 N  N   A GLU A 81  ? 0.26670 0.26210 0.23940 -0.01220 0.07970  -0.00350 1540 GLU A N   
1141 N  N   B GLU A 81  ? 0.26690 0.26170 0.24100 -0.00980 0.07740  -0.00470 1540 GLU A N   
1142 C  CA  A GLU A 81  ? 0.29720 0.27700 0.24500 -0.02080 0.03950  0.01580  1540 GLU A CA  
1143 C  CA  B GLU A 81  ? 0.29450 0.27540 0.24630 -0.01670 0.03870  0.01350  1540 GLU A CA  
1144 C  C   A GLU A 81  ? 0.29140 0.26610 0.20730 -0.01590 0.03410  0.02450  1540 GLU A C   
1145 C  C   B GLU A 81  ? 0.28950 0.26460 0.20890 -0.01670 0.03510  0.02440  1540 GLU A C   
1146 O  O   A GLU A 81  ? 0.32910 0.28569 0.23630 0.00970  0.01640  0.02420  1540 GLU A O   
1147 O  O   B GLU A 81  ? 0.32540 0.28279 0.23680 0.00480  0.02280  0.02420  1540 GLU A O   
1148 C  CB  A GLU A 81  ? 0.34140 0.30730 0.29980 -0.02290 0.02890  0.02890  1540 GLU A CB  
1149 C  CB  B GLU A 81  ? 0.33370 0.30430 0.29990 -0.01290 0.02920  0.02420  1540 GLU A CB  
1150 C  CG  A GLU A 81  ? 0.37260 0.33420 0.35210 -0.03030 0.02820  0.02570  1540 GLU A CG  
1151 C  CG  B GLU A 81  ? 0.36130 0.33000 0.35210 -0.01380 0.02850  0.01920  1540 GLU A CG  
1152 C  CD  A GLU A 81  ? 0.40160 0.35540 0.38140 -0.03200 0.02620  0.01650  1540 GLU A CD  
1153 C  CD  B GLU A 81  ? 0.38610 0.35050 0.38290 -0.01380 0.01640  0.01040  1540 GLU A CD  
1154 O  OE1 A GLU A 81  ? 0.40310 0.36000 0.38880 -0.03530 0.01820  0.01280  1540 GLU A OE1 
1155 O  OE1 B GLU A 81  ? 0.39620 0.36170 0.39010 -0.00880 0.02110  0.01180  1540 GLU A OE1 
1156 O  OE2 A GLU A 81  ? 0.42440 0.36740 0.40030 -0.02580 0.02550  0.01780  1540 GLU A OE2 
1157 O  OE2 B GLU A 81  ? 0.40680 0.35980 0.40560 -0.02640 0.02080  0.01340  1540 GLU A OE2 
1170 N  N   . ASN A 82  ? 0.26530 0.23850 0.16410 -0.03790 0.03500  0.03340  1541 ASN A N   
1171 C  CA  . ASN A 82  ? 0.24790 0.21239 0.13510 -0.03690 0.00410  0.01400  1541 ASN A CA  
1172 C  C   . ASN A 82  ? 0.22730 0.18170 0.14670 -0.04300 0.00240  0.00230  1541 ASN A C   
1173 O  O   . ASN A 82  ? 0.23820 0.18110 0.16930 -0.03100 0.00620  -0.00160 1541 ASN A O   
1174 C  CB  . ASN A 82  ? 0.21000 0.19810 0.14580 -0.03200 -0.00630 0.01090  1541 ASN A CB  
1175 C  CG  . ASN A 82  ? 0.19190 0.17210 0.14260 -0.01440 -0.00790 0.01980  1541 ASN A CG  
1176 O  OD1 . ASN A 82  ? 0.19040 0.14520 0.15970 -0.02360 -0.00380 0.01570  1541 ASN A OD1 
1177 N  ND2 . ASN A 82  ? 0.18890 0.15950 0.09410 -0.01140 -0.01610 0.03260  1541 ASN A ND2 
1184 N  N   . ALA A 83  ? 0.21970 0.16040 0.14520 -0.03290 -0.00560 0.01400  1542 ALA A N   
1185 C  CA  . ALA A 83  ? 0.22640 0.15060 0.13870 -0.01890 -0.00810 0.00700  1542 ALA A CA  
1186 C  C   . ALA A 83  ? 0.26520 0.16610 0.11750 -0.02400 -0.00220 0.00930  1542 ALA A C   
1187 O  O   . ALA A 83  ? 0.29360 0.18729 0.13700 -0.02810 -0.02370 0.00820  1542 ALA A O   
1188 C  CB  . ALA A 83  ? 0.25860 0.14360 0.17720 -0.01560 0.01020  -0.01220 1542 ALA A CB  
1194 N  N   . GLY A 84  ? 0.24670 0.17840 0.16160 -0.02050 -0.01000 0.03440  1543 GLY A N   
1195 C  CA  . GLY A 84  ? 0.27720 0.19410 0.18900 -0.01830 -0.01860 0.04440  1543 GLY A CA  
1196 C  C   . GLY A 84  ? 0.25180 0.20370 0.23390 -0.00500 -0.01940 0.04720  1543 GLY A C   
1197 O  O   . GLY A 84  ? 0.28220 0.21820 0.29520 -0.02010 -0.06320 0.05720  1543 GLY A O   
1201 N  N   . THR A 85  ? 0.23090 0.20100 0.17310 -0.01060 -0.00000 0.01930  1544 THR A N   
1202 C  CA  . THR A 85  ? 0.25230 0.19680 0.17890 -0.01520 -0.00290 0.00820  1544 THR A CA  
1203 C  C   . THR A 85  ? 0.26050 0.18810 0.13110 -0.00670 -0.01110 0.02160  1544 THR A C   
1204 O  O   . THR A 85  ? 0.30690 0.17340 0.22780 -0.00060 0.02940  0.02440  1544 THR A O   
1205 C  CB  . THR A 85  ? 0.27720 0.19550 0.19560 -0.02910 0.03170  0.01540  1544 THR A CB  
1206 O  OG1 . THR A 85  ? 0.25030 0.17640 0.20210 -0.03210 0.03050  0.01380  1544 THR A OG1 
1207 C  CG2 . THR A 85  ? 0.29020 0.20430 0.21920 -0.04660 0.02590  0.03090  1544 THR A CG2 
1215 N  N   . LEU A 86  ? 0.21240 0.19490 0.11490 -0.02560 -0.02450 0.01660  1545 LEU A N   
1216 C  CA  . LEU A 86  ? 0.20970 0.20860 0.12470 -0.01710 -0.03500 0.00970  1545 LEU A CA  
1217 C  C   . LEU A 86  ? 0.18760 0.21920 0.16820 -0.00130 -0.01860 0.03630  1545 LEU A C   
1218 O  O   . LEU A 86  ? 0.19520 0.21380 0.20040 0.01060  0.00240  0.01390  1545 LEU A O   
1219 C  CB  . LEU A 86  ? 0.19290 0.21160 0.14240 -0.01120 0.00430  0.00390  1545 LEU A CB  
1220 C  CG  . LEU A 86  ? 0.17850 0.21500 0.15760 -0.01390 0.02220  0.00800  1545 LEU A CG  
1221 C  CD1 . LEU A 86  ? 0.19930 0.21450 0.17170 0.00050  0.02880  -0.01680 1545 LEU A CD1 
1222 C  CD2 . LEU A 86  ? 0.20420 0.22130 0.20800 -0.01980 0.02580  0.01020  1545 LEU A CD2 
1234 N  N   . GLY A 87  ? 0.21800 0.23520 0.22050 0.00360  -0.02690 0.02500  1546 GLY A N   
1235 C  CA  . GLY A 87  ? 0.20970 0.25510 0.23350 0.01420  -0.04290 0.00770  1546 GLY A CA  
1236 C  C   . GLY A 87  ? 0.23080 0.27630 0.21720 0.04340  -0.04550 -0.01160 1546 GLY A C   
1237 O  O   . GLY A 87  ? 0.26300 0.29679 0.23130 0.05370  -0.03250 -0.02090 1546 GLY A O   
1241 N  N   . THR A 88  ? 0.27040 0.26850 0.23000 0.05000  -0.05970 -0.01280 1547 THR A N   
1242 C  CA  . THR A 88  ? 0.32770 0.26600 0.25140 0.03660  -0.05650 0.01330  1547 THR A CA  
1243 C  C   . THR A 88  ? 0.28250 0.23750 0.22880 0.03330  -0.02680 0.00640  1547 THR A C   
1244 O  O   . THR A 88  ? 0.30790 0.26219 0.25910 0.06080  -0.01710 -0.01450 1547 THR A O   
1245 C  CB  . THR A 88  ? 0.43440 0.29600 0.27550 0.02270  -0.06520 0.02060  1547 THR A CB  
1246 O  OG1 . THR A 88  ? 0.48220 0.31879 0.34770 0.01120  -0.07880 0.01570  1547 THR A OG1 
1247 C  CG2 . THR A 88  ? 0.46640 0.30880 0.31650 0.01360  -0.04750 0.03660  1547 THR A CG2 
1255 N  N   . VAL A 89  ? 0.22320 0.19470 0.18850 0.00370  0.00330  0.03010  1548 VAL A N   
1256 C  CA  . VAL A 89  ? 0.19710 0.18140 0.16520 -0.02120 0.02880  0.03180  1548 VAL A CA  
1257 C  C   . VAL A 89  ? 0.15690 0.15640 0.16960 -0.02070 0.01080  0.02680  1548 VAL A C   
1258 O  O   . VAL A 89  ? 0.16010 0.14600 0.23470 -0.02810 0.00680  0.00630  1548 VAL A O   
1259 C  CB  . VAL A 89  ? 0.23640 0.20230 0.23430 -0.03640 0.04880  0.03500  1548 VAL A CB  
1260 C  CG1 . VAL A 89  ? 0.25790 0.20660 0.24940 -0.06490 0.04620  0.04280  1548 VAL A CG1 
1261 C  CG2 . VAL A 89  ? 0.20550 0.22419 0.23070 -0.02260 0.03770  0.01050  1548 VAL A CG2 
1271 N  N   . ALA A 90  ? 0.15640 0.14240 0.16580 -0.02050 -0.01980 0.01600  1549 ALA A N   
1272 C  CA  . ALA A 90  ? 0.15050 0.14730 0.17780 -0.00720 -0.01890 0.01700  1549 ALA A CA  
1273 C  C   . ALA A 90  ? 0.14840 0.13460 0.18660 -0.01510 -0.01510 0.02570  1549 ALA A C   
1274 O  O   . ALA A 90  ? 0.14510 0.14060 0.20090 -0.00390 -0.03180 0.00800  1549 ALA A O   
1275 C  CB  . ALA A 90  ? 0.15090 0.15460 0.18450 -0.02230 -0.00940 0.00580  1549 ALA A CB  
1281 N  N   . GLY A 91  ? 0.14410 0.13720 0.16390 -0.01040 -0.01770 0.02900  1550 GLY A N   
1282 C  CA  . GLY A 91  ? 0.12440 0.15449 0.14530 -0.00610 -0.01170 0.01990  1550 GLY A CA  
1283 C  C   . GLY A 91  ? 0.13730 0.15000 0.13820 0.00650  0.01490  0.00260  1550 GLY A C   
1284 O  O   . GLY A 91  ? 0.15160 0.16679 0.15380 -0.01320 0.00750  0.00310  1550 GLY A O   
1288 N  N   A SER A 92  ? 0.13320 0.13650 0.13990 0.01180  -0.01130 0.02050  1551 SER A N   
1289 C  CA  A SER A 92  ? 0.15470 0.13870 0.15310 -0.00010 0.00140  0.01770  1551 SER A CA  
1290 C  CA  B SER A 92  ? 0.22970 0.19610 0.17950 0.00170  0.01510  0.01260  1551 SER A CA  
1291 C  C   A SER A 92  ? 0.14130 0.12640 0.13040 0.00640  -0.00490 0.01610  1551 SER A C   
1292 O  O   A SER A 92  ? 0.14260 0.11440 0.16850 0.00270  -0.00840 0.00420  1551 SER A O   
1293 C  CB  A SER A 92  ? 0.20390 0.15400 0.19930 -0.01650 0.02610  -0.00730 1551 SER A CB  
1294 C  CB  B SER A 92  ? 0.22100 0.19060 0.17520 0.00750  0.01110  0.02390  1551 SER A CB  
1295 O  OG  A SER A 92  ? 0.25730 0.16730 0.24160 -0.01240 -0.00550 -0.00170 1551 SER A OG  
1296 O  OG  B SER A 92  ? 0.19930 0.17990 0.13920 0.01600  -0.01830 0.04330  1551 SER A OG  
1307 N  N   . ALA A 93  ? 0.15220 0.13680 0.13360 0.00720  -0.01090 0.03190  1552 ALA A N   
1308 C  CA  . ALA A 93  ? 0.13160 0.13630 0.13520 0.01280  -0.01190 0.01870  1552 ALA A CA  
1309 C  C   . ALA A 93  ? 0.12220 0.11180 0.14510 0.01970  -0.00820 0.01540  1552 ALA A C   
1310 O  O   . ALA A 93  ? 0.10780 0.11400 0.20200 0.00810  0.00020  -0.00480 1552 ALA A O   
1311 C  CB  . ALA A 93  ? 0.13810 0.16039 0.16560 0.01240  0.00870  -0.01020 1552 ALA A CB  
1317 N  N   . ALA A 94  ? 0.12500 0.10860 0.16950 0.01220  -0.00040 0.00730  1553 ALA A N   
1318 C  CA  . ALA A 94  ? 0.11550 0.09800 0.18350 -0.00360 -0.01410 0.01000  1553 ALA A CA  
1319 C  C   . ALA A 94  ? 0.10440 0.09990 0.15520 -0.00450 -0.02850 -0.00070 1553 ALA A C   
1320 O  O   . ALA A 94  ? 0.11940 0.11390 0.18750 -0.00280 -0.00400 -0.00180 1553 ALA A O   
1321 C  CB  . ALA A 94  ? 0.11810 0.09150 0.17460 -0.00400 -0.01130 -0.00490 1553 ALA A CB  
1327 N  N   . GLY A 95  ? 0.12700 0.09620 0.16670 -0.00570 0.00880  -0.01280 1554 GLY A N   
1328 C  CA  . GLY A 95  ? 0.11470 0.09660 0.15130 -0.00150 -0.00520 0.01210  1554 GLY A CA  
1329 C  C   . GLY A 95  ? 0.12400 0.10340 0.13650 -0.00120 0.00740  -0.00100 1554 GLY A C   
1330 O  O   . GLY A 95  ? 0.09990 0.10110 0.15510 -0.00840 0.00040  0.00980  1554 GLY A O   
1334 N  N   . LEU A 96  ? 0.11060 0.11000 0.15100 -0.00450 0.01810  0.00790  1555 LEU A N   
1335 C  CA  . LEU A 96  ? 0.13969 0.10700 0.10420 -0.00360 -0.00210 0.01730  1555 LEU A CA  
1336 C  C   . LEU A 96  ? 0.10960 0.10670 0.14610 0.00350  0.03230  0.00120  1555 LEU A C   
1337 O  O   . LEU A 96  ? 0.11550 0.11540 0.14730 -0.00140 0.00570  0.03620  1555 LEU A O   
1338 C  CB  . LEU A 96  ? 0.13750 0.12210 0.10190 0.00280  0.00060  -0.00500 1555 LEU A CB  
1339 C  CG  . LEU A 96  ? 0.14770 0.12330 0.10980 0.00180  0.00380  -0.01400 1555 LEU A CG  
1340 C  CD1 . LEU A 96  ? 0.15900 0.12230 0.11630 0.01260  -0.00600 0.00610  1555 LEU A CD1 
1341 C  CD2 . LEU A 96  ? 0.16020 0.14179 0.15420 0.01500  -0.00960 -0.03290 1555 LEU A CD2 
1353 N  N   . KCX A 97  ? 0.09990 0.10350 0.18200 -0.00250 0.01110  0.01340  1556 KCX A N   
1354 C  CA  . KCX A 97  ? 0.09910 0.11460 0.13840 -0.01070 0.00680  0.00600  1556 KCX A CA  
1355 C  CB  . KCX A 97  ? 0.11360 0.11490 0.14750 -0.01580 -0.00440 0.00180  1556 KCX A CB  
1356 C  CG  . KCX A 97  ? 0.11100 0.12729 0.17010 -0.01350 -0.02860 0.00340  1556 KCX A CG  
1357 C  CD  . KCX A 97  ? 0.10770 0.12180 0.13660 -0.00690 -0.00930 0.00850  1556 KCX A CD  
1358 C  CE  . KCX A 97  ? 0.11280 0.11600 0.13520 -0.01420 -0.00980 -0.00530 1556 KCX A CE  
1359 N  NZ  . KCX A 97  ? 0.11350 0.10260 0.15600 0.00040  -0.00410 -0.00790 1556 KCX A NZ  
1360 C  C   . KCX A 97  ? 0.10590 0.11280 0.09300 -0.00840 0.00990  0.01190  1556 KCX A C   
1361 O  O   . KCX A 97  ? 0.12860 0.12030 0.11720 -0.00940 0.01080  0.00830  1556 KCX A O   
1362 C  CX  . KCX A 97  ? 0.10430 0.10140 0.15460 -0.01680 0.02650  0.00590  1556 KCX A CX  
1363 O  OQ1 . KCX A 97  ? 0.09580 0.09810 0.15830 -0.00460 -0.01150 0.00880  1556 KCX A OQ1 
1364 O  OQ2 . KCX A 97  ? 0.09000 0.10540 0.16950 -0.00480 0.00500  0.00120  1556 KCX A OQ2 
1376 N  N   . LEU A 98  ? 0.10330 0.10190 0.15250 -0.01380 0.00930  0.00630  1557 LEU A N   
1377 C  CA  . LEU A 98  ? 0.12560 0.11370 0.11420 0.00170  0.00600  -0.00350 1557 LEU A CA  
1378 C  C   . LEU A 98  ? 0.11950 0.11850 0.09420 -0.00340 -0.00210 0.00800  1557 LEU A C   
1379 O  O   . LEU A 98  ? 0.11150 0.13360 0.12240 0.00720  0.01970  0.00890  1557 LEU A O   
1380 C  CB  . LEU A 98  ? 0.13210 0.12670 0.17350 -0.01250 -0.00960 -0.02840 1557 LEU A CB  
1381 C  CG  . LEU A 98  ? 0.17470 0.14710 0.27580 -0.02750 -0.05790 -0.00870 1557 LEU A CG  
1382 C  CD1 . LEU A 98  ? 0.17180 0.16969 0.28140 -0.03920 -0.06860 -0.01440 1557 LEU A CD1 
1383 C  CD2 . LEU A 98  ? 0.21210 0.15380 0.32560 -0.02870 -0.11690 -0.00650 1557 LEU A CD2 
1395 N  N   . TYR A 99  ? 0.10860 0.11860 0.14910 0.00580  0.00950  0.01440  1558 TYR A N   
1396 C  CA  . TYR A 99  ? 0.09870 0.12730 0.15320 -0.00250 0.00840  -0.00130 1558 TYR A CA  
1397 C  C   . TYR A 99  ? 0.11670 0.12730 0.11790 -0.00460 -0.00710 -0.00490 1558 TYR A C   
1398 O  O   . TYR A 99  ? 0.15230 0.12930 0.12560 -0.00450 0.00600  0.00720  1558 TYR A O   
1399 C  CB  . TYR A 99  ? 0.09830 0.13250 0.14230 -0.00230 0.01740  -0.00470 1558 TYR A CB  
1400 C  CG  . TYR A 99  ? 0.10290 0.13640 0.12040 -0.00740 0.01790  -0.01850 1558 TYR A CG  
1401 C  CD1 . TYR A 99  ? 0.09530 0.14870 0.11840 -0.01590 0.00510  -0.03850 1558 TYR A CD1 
1402 C  CD2 . TYR A 99  ? 0.11720 0.14000 0.11330 -0.01970 0.00320  -0.02170 1558 TYR A CD2 
1403 C  CE1 . TYR A 99  ? 0.10750 0.14760 0.12630 -0.00990 -0.01040 -0.02540 1558 TYR A CE1 
1404 C  CE2 . TYR A 99  ? 0.11920 0.13670 0.13610 -0.02220 -0.00250 -0.01300 1558 TYR A CE2 
1405 C  CZ  . TYR A 99  ? 0.10690 0.13740 0.13250 -0.02230 -0.00790 -0.01430 1558 TYR A CZ  
1406 O  OH  . TYR A 99  ? 0.11820 0.14220 0.15740 -0.02610 -0.00980 -0.01460 1558 TYR A OH  
1416 N  N   . LEU A 100 ? 0.13990 0.12430 0.14370 -0.00340 0.01380  -0.00260 1559 LEU A N   
1417 C  CA  . LEU A 100 ? 0.14300 0.12720 0.16000 0.00360  0.01230  -0.01440 1559 LEU A CA  
1418 C  C   . LEU A 100 ? 0.13080 0.13240 0.18280 -0.01060 0.01330  -0.00790 1559 LEU A C   
1419 O  O   . LEU A 100 ? 0.14750 0.14310 0.27320 -0.00670 0.00650  -0.04240 1559 LEU A O   
1420 C  CB  . LEU A 100 ? 0.13280 0.12870 0.16110 -0.00630 0.00110  -0.02900 1559 LEU A CB  
1421 C  CG  . LEU A 100 ? 0.15270 0.14540 0.19130 -0.03200 -0.00130 -0.01260 1559 LEU A CG  
1422 C  CD1 . LEU A 100 ? 0.13330 0.14860 0.18430 -0.02850 0.00870  -0.01060 1559 LEU A CD1 
1423 C  CD2 . LEU A 100 ? 0.18800 0.14930 0.21380 -0.03630 -0.00770 -0.02270 1559 LEU A CD2 
1435 N  N   A ASN A 101 ? 0.11220 0.13330 0.16050 0.00600  0.00920  -0.00680 1560 ASN A N   
1436 N  N   B ASN A 101 ? 0.15310 0.14530 0.18070 -0.00740 0.00910  -0.02130 1560 ASN A N   
1437 C  CA  A ASN A 101 ? 0.08820 0.15010 0.19070 0.01160  0.02940  0.01530  1560 ASN A CA  
1438 C  CA  B ASN A 101 ? 0.17160 0.17040 0.20710 -0.00990 0.03390  -0.03360 1560 ASN A CA  
1439 C  C   A ASN A 101 ? 0.08130 0.19200 0.27320 0.01530  0.02520  0.05860  1560 ASN A C   
1440 C  C   B ASN A 101 ? 0.20300 0.19840 0.22720 -0.01650 0.04430  -0.02230 1560 ASN A C   
1441 O  O   A ASN A 101 ? 0.12590 0.20179 0.37659 0.01970  0.06020  0.08390  1560 ASN A O   
1442 O  O   B ASN A 101 ? 0.20080 0.18620 0.22300 -0.01780 0.05010  -0.04860 1560 ASN A O   
1443 C  CB  A ASN A 101 ? 0.07250 0.13390 0.16160 0.00680  0.00730  -0.00710 1560 ASN A CB  
1444 C  CB  B ASN A 101 ? 0.17480 0.17150 0.20960 -0.00770 0.01270  -0.03930 1560 ASN A CB  
1445 C  CG  A ASN A 101 ? 0.08900 0.11320 0.15340 0.01290  0.00890  -0.00140 1560 ASN A CG  
1446 C  CG  B ASN A 101 ? 0.17380 0.16990 0.20560 0.00480  0.01590  -0.03350 1560 ASN A CG  
1447 O  OD1 A ASN A 101 ? 0.08900 0.10280 0.17360 0.00330  0.01330  -0.00200 1560 ASN A OD1 
1448 O  OD1 B ASN A 101 ? 0.16590 0.16720 0.20870 0.01760  0.00040  -0.04040 1560 ASN A OD1 
1449 N  ND2 A ASN A 101 ? 0.12100 0.10530 0.21640 0.01710  0.03220  -0.01880 1560 ASN A ND2 
1450 N  ND2 B ASN A 101 ? 0.18440 0.17000 0.25230 -0.00600 0.03090  -0.03270 1560 ASN A ND2 
1463 N  N   A GLU A 102 ? 0.07260 0.21900 0.23950 -0.01260 0.00740  0.04010  1561 GLU A N   
1464 N  N   B GLU A 102 ? 0.26400 0.24300 0.29470 -0.02110 -0.00270 -0.00360 1561 GLU A N   
1465 C  CA  A GLU A 102 ? 0.13040 0.24071 0.23640 0.01040  0.01430  -0.00480 1561 GLU A CA  
1466 C  CA  B GLU A 102 ? 0.30330 0.28481 0.34270 -0.01660 -0.01400 -0.00710 1561 GLU A CA  
1467 C  C   A GLU A 102 ? 0.13850 0.21640 0.18930 0.02120  -0.00620 -0.02610 1561 GLU A C   
1468 C  C   B GLU A 102 ? 0.32840 0.29860 0.34390 -0.02280 -0.01230 -0.00570 1561 GLU A C   
1469 O  O   A GLU A 102 ? 0.14910 0.20470 0.19220 0.03430  0.00890  -0.02200 1561 GLU A O   
1470 O  O   B GLU A 102 ? 0.33840 0.29680 0.34250 -0.03650 -0.01180 0.00530  1561 GLU A O   
1471 C  CB  A GLU A 102 ? 0.37879 0.37748 0.37949 0.00010  0.00010  -0.00010 1561 GLU A CB  
1472 C  CB  B GLU A 102 ? 0.37959 0.37828 0.37990 -0.00010 -0.00000 -0.00000 1561 GLU A CB  
1477 N  N   A THR A 103 ? 0.10930 0.19800 0.14950 0.03890  -0.00010 -0.03750 1562 THR A N   
1478 N  N   B THR A 103 ? 0.33880 0.30910 0.34040 -0.02310 -0.02520 -0.00420 1562 THR A N   
1479 C  CA  A THR A 103 ? 0.13080 0.19362 0.15950 0.02750  0.05120  -0.00980 1562 THR A CA  
1480 C  CA  B THR A 103 ? 0.35180 0.33240 0.36370 -0.01350 0.01480  0.00040  1562 THR A CA  
1481 C  C   A THR A 103 ? 0.09940 0.17760 0.19520 -0.00210 0.01780  -0.03030 1562 THR A C   
1482 C  C   B THR A 103 ? 0.38490 0.34470 0.38780 -0.01580 0.02660  0.01030  1562 THR A C   
1483 O  O   A THR A 103 ? 0.11120 0.16640 0.21200 -0.01410 -0.00840 -0.01600 1562 THR A O   
1484 O  O   B THR A 103 ? 0.38520 0.34490 0.38710 -0.01810 0.07710  0.01460  1562 THR A O   
1485 C  CB  A THR A 103 ? 0.37879 0.37667 0.37939 0.00030  0.00030  -0.00000 1562 THR A CB  
1486 C  CB  B THR A 103 ? 0.37990 0.37919 0.38000 -0.00010 0.00000  0.00000  1562 THR A CB  
1487 O  OG1 A THR A 103 ? 0.38000 0.37990 0.38000 0.00000  0.00000  0.00000  1562 THR A OG1 
1488 O  OG1 B THR A 103 ? 0.38000 0.38000 0.38000 -0.00000 0.00000  -0.00000 1562 THR A OG1 
1489 C  CG2 A THR A 103 ? 0.38000 0.38000 0.38000 0.00000  0.00000  0.00000  1562 THR A CG2 
1490 C  CG2 B THR A 103 ? 0.38000 0.38000 0.38000 0.00000  0.00000  -0.00000 1562 THR A CG2 
1504 N  N   A PHE A 104 ? 0.10040 0.18610 0.18330 -0.00410 0.05270  -0.03340 1563 PHE A N   
1505 N  N   B PHE A 104 ? 0.39730 0.35850 0.39300 -0.01480 0.00650  0.02260  1563 PHE A N   
1506 C  CA  A PHE A 104 ? 0.14771 0.23641 0.21990 -0.01600 0.08620  -0.02860 1563 PHE A CA  
1507 C  CA  B PHE A 104 ? 0.39660 0.37010 0.40010 -0.01620 -0.00200 0.02720  1563 PHE A CA  
1508 C  C   A PHE A 104 ? 0.20500 0.22450 0.24340 -0.00450 0.07730  -0.03080 1563 PHE A C   
1509 C  C   B PHE A 104 ? 0.36980 0.35790 0.37720 -0.02140 0.00420  0.02670  1563 PHE A C   
1510 O  O   A PHE A 104 ? 0.23070 0.23460 0.27350 0.06050  0.08320  -0.06330 1563 PHE A O   
1511 O  O   B PHE A 104 ? 0.35900 0.35760 0.38520 -0.01920 -0.02560 0.03000  1563 PHE A O   
1512 C  CB  A PHE A 104 ? 0.37869 0.37738 0.37959 -0.00010 0.00030  -0.00010 1563 PHE A CB  
1513 C  CB  B PHE A 104 ? 0.38010 0.37990 0.38000 -0.00010 -0.00000 0.00010  1563 PHE A CB  
1514 C  CG  A PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 0.00000  -0.00000 1563 PHE A CG  
1515 C  CG  B PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 -0.00000 1563 PHE A CG  
1516 C  CD1 A PHE A 104 ? 0.38000 0.38000 0.38000 0.00000  0.00000  -0.00000 1563 PHE A CD1 
1517 C  CD1 B PHE A 104 ? 0.38000 0.38000 0.38000 0.00000  0.00000  -0.00000 1563 PHE A CD1 
1518 C  CD2 A PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 0.00000  1563 PHE A CD2 
1519 C  CD2 B PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 -0.00000 1563 PHE A CD2 
1520 C  CE1 A PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 0.00000  -0.00000 1563 PHE A CE1 
1521 C  CE1 B PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 0.00000  1563 PHE A CE1 
1522 C  CE2 A PHE A 104 ? 0.38000 0.38000 0.38000 0.00000  -0.00000 -0.00000 1563 PHE A CE2 
1523 C  CE2 B PHE A 104 ? 0.38000 0.38000 0.38000 0.00000  0.00000  -0.00000 1563 PHE A CE2 
1524 C  CZ  A PHE A 104 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 -0.00000 1563 PHE A CZ  
1525 C  CZ  B PHE A 104 ? 0.38000 0.38000 0.38000 0.00000  -0.00000 -0.00000 1563 PHE A CZ  
1543 N  N   A SER A 105 ? 0.19210 0.24190 0.21960 -0.01920 0.07390  -0.00300 1564 SER A N   
1544 N  N   B SER A 105 ? 0.34010 0.34270 0.36340 -0.02770 0.01660  0.01440  1564 SER A N   
1545 C  CA  A SER A 105 ? 0.16680 0.26140 0.23450 -0.04590 0.06230  0.00660  1564 SER A CA  
1546 C  CA  B SER A 105 ? 0.32280 0.32680 0.34920 -0.03230 0.03710  0.00480  1564 SER A CA  
1547 C  C   A SER A 105 ? 0.17360 0.26790 0.22640 -0.06130 0.04060  -0.00760 1564 SER A C   
1548 C  C   B SER A 105 ? 0.31470 0.30690 0.33090 -0.03530 0.00700  -0.00710 1564 SER A C   
1549 O  O   A SER A 105 ? 0.15620 0.26090 0.16980 -0.04640 0.06810  -0.04100 1564 SER A O   
1550 O  O   B SER A 105 ? 0.29950 0.30500 0.34330 -0.03720 0.02790  -0.01660 1564 SER A O   
1551 C  CB  A SER A 105 ? 0.16770 0.26960 0.27770 -0.04930 0.05740  0.02840  1564 SER A CB  
1552 C  CB  B SER A 105 ? 0.33910 0.33530 0.36540 -0.03090 0.04170  0.00230  1564 SER A CB  
1553 O  OG  A SER A 105 ? 0.20440 0.28010 0.29910 -0.05650 0.04170  0.02830  1564 SER A OG  
1554 O  OG  B SER A 105 ? 0.34030 0.33590 0.37190 -0.02960 0.05650  0.00740  1564 SER A OG  
1564 N  N   A GLU A 106 ? 0.18200 0.27750 0.25980 -0.07930 0.00310  -0.01360 1565 GLU A N   
1565 N  N   B GLU A 106 ? 0.29740 0.28940 0.30770 -0.03890 0.01250  0.00460  1565 GLU A N   
1566 C  CA  A GLU A 106 ? 0.22920 0.30380 0.26880 -0.07320 -0.00300 -0.00450 1565 GLU A CA  
1567 C  CA  B GLU A 106 ? 0.27550 0.29360 0.27640 -0.03790 0.02190  0.01550  1565 GLU A CA  
1568 C  C   A GLU A 106 ? 0.20070 0.28630 0.28960 -0.08520 0.00800  -0.01720 1565 GLU A C   
1569 C  C   B GLU A 106 ? 0.22440 0.24550 0.23200 -0.03850 0.02430  0.02400  1565 GLU A C   
1570 O  O   A GLU A 106 ? 0.20270 0.30559 0.26900 -0.08100 0.03530  0.00500  1565 GLU A O   
1571 O  O   B GLU A 106 ? 0.23960 0.23820 0.20920 -0.04290 0.01910  0.03970  1565 GLU A O   
1572 C  CB  A GLU A 106 ? 0.37919 0.37869 0.37969 -0.00071 -0.00000 -0.00000 1565 GLU A CB  
1573 C  CB  B GLU A 106 ? 0.37949 0.37849 0.37959 -0.00040 0.00010  0.00010  1565 GLU A CB  
1574 C  CG  A GLU A 106 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 -0.00000 1565 GLU A CG  
1575 C  CG  B GLU A 106 ? 0.37990 0.38000 0.38000 -0.00000 0.00000  0.00000  1565 GLU A CG  
1576 C  CD  A GLU A 106 ? 0.38000 0.38000 0.38000 0.00000  -0.00000 0.00000  1565 GLU A CD  
1577 C  CD  B GLU A 106 ? 0.38000 0.38000 0.38000 -0.00000 -0.00000 -0.00000 1565 GLU A CD  
1578 O  OE1 A GLU A 106 ? 0.38000 0.38000 0.38010 -0.00000 -0.00000 0.00010  1565 GLU A OE1 
1579 O  OE1 B GLU A 106 ? 0.38000 0.38000 0.38000 0.00010  -0.00000 -0.00000 1565 GLU A OE1 
1580 O  OE2 A GLU A 106 ? 0.38000 0.38000 0.38000 -0.00000 0.00000  0.00010  1565 GLU A OE2 
1581 O  OE2 B GLU A 106 ? 0.38010 0.38000 0.38010 -0.00000 -0.00000 0.00000  1565 GLU A OE2 
1594 N  N   A LEU A 107 ? 0.17020 0.25400 0.27380 -0.08000 0.02000  -0.03770 1566 LEU A N   
1595 N  N   B LEU A 107 ? 0.19700 0.22390 0.25390 -0.04130 0.03690  0.01740  1566 LEU A N   
1596 C  CA  A LEU A 107 ? 0.15620 0.22280 0.27250 -0.07720 0.04390  -0.02800 1566 LEU A CA  
1597 C  CA  B LEU A 107 ? 0.21000 0.21550 0.28570 -0.02930 0.03000  -0.01140 1566 LEU A CA  
1598 C  C   A LEU A 107 ? 0.18350 0.22750 0.26540 -0.04390 0.06280  -0.05590 1566 LEU A C   
1599 C  C   B LEU A 107 ? 0.20760 0.19780 0.27190 -0.01650 0.04590  -0.03630 1566 LEU A C   
1600 O  O   A LEU A 107 ? 0.16380 0.21720 0.23630 -0.02480 0.06450  -0.06630 1566 LEU A O   
1601 O  O   B LEU A 107 ? 0.16040 0.18000 0.19430 -0.01640 0.05570  -0.04990 1566 LEU A O   
1602 C  CB  A LEU A 107 ? 0.21650 0.19600 0.27550 -0.07520 0.00830  -0.00110 1566 LEU A CB  
1603 C  CB  B LEU A 107 ? 0.22860 0.22170 0.28450 -0.02630 0.01070  0.00700  1566 LEU A CB  
1604 C  CG  A LEU A 107 ? 0.25820 0.19100 0.29470 -0.06550 0.00340  0.02030  1566 LEU A CG  
1605 C  CG  B LEU A 107 ? 0.26530 0.23280 0.31090 -0.02240 -0.00610 0.02010  1566 LEU A CG  
1606 C  CD1 A LEU A 107 ? 0.28630 0.20210 0.33170 -0.05640 -0.00550 0.01420  1566 LEU A CD1 
1607 C  CD1 B LEU A 107 ? 0.29390 0.23130 0.31430 0.00060  0.00440  0.02310  1566 LEU A CD1 
1608 C  CD2 A LEU A 107 ? 0.28210 0.18250 0.29200 -0.04820 0.03240  0.03920  1566 LEU A CD2 
1609 C  CD2 B LEU A 107 ? 0.27270 0.24999 0.35140 -0.02020 -0.00420 0.01520  1566 LEU A CD2 
1632 N  N   A ARG A 108 ? 0.26610 0.25480 0.33660 -0.02090 0.05250  -0.05500 1567 ARG A N   
1633 N  N   B ARG A 108 ? 0.22580 0.19720 0.26190 -0.01550 0.05340  -0.03600 1567 ARG A N   
1634 C  CA  A ARG A 108 ? 0.34030 0.27580 0.33630 0.01970  0.04070  -0.03470 1567 ARG A CA  
1635 C  CA  B ARG A 108 ? 0.22480 0.20240 0.25630 -0.02170 0.09690  -0.03410 1567 ARG A CA  
1636 C  C   A ARG A 108 ? 0.37570 0.27340 0.30470 0.03610  0.03610  -0.02770 1567 ARG A C   
1637 C  C   B ARG A 108 ? 0.19020 0.19770 0.22770 -0.04870 0.11110  -0.04810 1567 ARG A C   
1638 O  O   A ARG A 108 ? 0.40060 0.27680 0.26660 0.03660  0.06880  -0.03370 1567 ARG A O   
1639 O  O   B ARG A 108 ? 0.16160 0.19820 0.28000 -0.05470 0.08540  -0.04290 1567 ARG A O   
1640 C  CB  A ARG A 108 ? 0.35830 0.29179 0.33550 0.02630  0.03820  -0.02840 1567 ARG A CB  
1641 C  CB  B ARG A 108 ? 0.22400 0.21540 0.28450 -0.02960 0.10040  -0.03200 1567 ARG A CB  
1646 N  N   A LEU A 109 ? 0.36360 0.26110 0.28090 0.02970  0.04090  -0.03180 1568 LEU A N   
1647 N  N   B LEU A 109 ? 0.24630 0.19920 0.25930 -0.02450 0.04800  -0.03730 1568 LEU A N   
1648 C  CA  A LEU A 109 ? 0.29640 0.23500 0.30120 0.00740  0.02980  -0.01780 1568 LEU A CA  
1649 C  CA  B LEU A 109 ? 0.24880 0.20560 0.30570 -0.02150 0.02110  -0.02730 1568 LEU A CA  
1650 C  C   A LEU A 109 ? 0.27950 0.23370 0.36510 -0.01410 0.02310  -0.01990 1568 LEU A C   
1651 C  C   B LEU A 109 ? 0.26480 0.22270 0.36470 -0.03070 0.01050  -0.02880 1568 LEU A C   
1652 O  O   A LEU A 109 ? 0.30150 0.22580 0.42410 -0.01040 0.01510  -0.00100 1568 LEU A O   
1653 O  O   B LEU A 109 ? 0.29830 0.22310 0.41820 -0.02590 -0.01000 -0.02260 1568 LEU A O   
1654 C  CB  A LEU A 109 ? 0.25960 0.21540 0.25610 -0.00130 0.01370  0.00430  1568 LEU A CB  
1655 C  CB  B LEU A 109 ? 0.22860 0.20450 0.26730 -0.02310 0.00060  -0.01090 1568 LEU A CB  
1656 C  CG  A LEU A 109 ? 0.23840 0.20670 0.21410 -0.00630 0.01900  0.01910  1568 LEU A CG  
1657 C  CG  B LEU A 109 ? 0.23720 0.21370 0.23860 -0.01640 0.00550  -0.00030 1568 LEU A CG  
1658 C  CD1 A LEU A 109 ? 0.24790 0.19700 0.20320 -0.00640 0.04320  0.02560  1568 LEU A CD1 
1659 C  CD1 B LEU A 109 ? 0.25020 0.21080 0.22830 -0.01280 0.02280  0.00810  1568 LEU A CD1 
1660 C  CD2 A LEU A 109 ? 0.24790 0.20970 0.22780 -0.01230 0.02190  0.02760  1568 LEU A CD2 
1661 C  CD2 B LEU A 109 ? 0.25280 0.22170 0.24580 -0.01810 0.00470  0.00300  1568 LEU A CD2 
1683 N  N   . ASP A 110 ? 0.26290 0.23520 0.42899 -0.03100 0.03100  -0.04030 1569 ASP A N   
1684 C  CA  . ASP A 110 ? 0.31679 0.24530 0.44620 -0.03280 0.04020  -0.06020 1569 ASP A CA  
1685 C  C   . ASP A 110 ? 0.24820 0.20800 0.47250 -0.02290 0.02830  -0.06580 1569 ASP A C   
1686 O  O   . ASP A 110 ? 0.28490 0.21050 0.51200 0.01350  0.02850  -0.08840 1569 ASP A O   
1687 C  CB  . ASP A 110 ? 0.37949 0.29429 0.47250 -0.05170 0.06490  -0.02250 1569 ASP A CB  
1690 N  N   . SER A 111 ? 0.19120 0.17740 0.39300 -0.02420 0.07750  -0.05240 1570 SER A N   
1691 C  CA  . SER A 111 ? 0.18990 0.15470 0.28270 -0.00930 0.04910  -0.02700 1570 SER A CA  
1692 C  C   . SER A 111 ? 0.17440 0.13710 0.21840 -0.01080 0.03070  -0.04150 1570 SER A C   
1693 O  O   . SER A 111 ? 0.18510 0.12460 0.21140 -0.00710 0.00880  -0.03570 1570 SER A O   
1694 C  CB  . SER A 111 ? 0.23180 0.16590 0.26250 0.00530  0.10930  0.00280  1570 SER A CB  
1695 O  OG  . SER A 111 ? 0.23260 0.17830 0.23700 0.01170  0.05630  0.02920  1570 SER A OG  
1701 N  N   . VAL A 112 ? 0.16440 0.13140 0.19380 -0.01320 0.00200  -0.02770 1571 VAL A N   
1702 C  CA  A VAL A 112 ? 0.18000 0.12880 0.16390 -0.02560 -0.00850 -0.01870 1571 VAL A CA  
1703 C  CA  B VAL A 112 ? 0.18230 0.12910 0.16620 -0.02160 -0.00540 -0.02300 1571 VAL A CA  
1704 C  C   . VAL A 112 ? 0.17980 0.11480 0.14270 -0.02390 0.00680  -0.01540 1571 VAL A C   
1705 O  O   . VAL A 112 ? 0.18430 0.12270 0.17420 0.00310  0.00420  -0.01380 1571 VAL A O   
1706 C  CB  A VAL A 112 ? 0.19000 0.14120 0.19490 -0.00960 -0.02890 -0.00290 1571 VAL A CB  
1707 C  CB  B VAL A 112 ? 0.20060 0.14080 0.18560 -0.00890 -0.02730 -0.02430 1571 VAL A CB  
1708 C  CG1 A VAL A 112 ? 0.16720 0.13960 0.18470 -0.00210 0.01040  0.01370  1571 VAL A CG1 
1709 C  CG1 B VAL A 112 ? 0.21350 0.14920 0.17280 0.00430  0.00420  -0.03120 1571 VAL A CG1 
1710 C  CG2 A VAL A 112 ? 0.23140 0.15859 0.17870 -0.01210 -0.02390 -0.01010 1571 VAL A CG2 
1711 C  CG2 B VAL A 112 ? 0.22130 0.14560 0.17700 -0.01170 -0.04220 -0.03040 1571 VAL A CG2 
1730 N  N   . VAL A 113 ? 0.18160 0.11280 0.16420 0.00230  -0.02330 -0.00230 1572 VAL A N   
1731 C  CA  . VAL A 113 ? 0.19590 0.12380 0.15470 0.00050  -0.01220 -0.00220 1572 VAL A CA  
1732 C  C   . VAL A 113 ? 0.19620 0.11810 0.18460 0.00370  -0.00610 0.00510  1572 VAL A C   
1733 O  O   . VAL A 113 ? 0.20780 0.11050 0.16170 0.00500  -0.00200 -0.00280 1572 VAL A O   
1734 C  CB  . VAL A 113 ? 0.23850 0.14870 0.17380 0.01090  -0.03080 -0.01440 1572 VAL A CB  
1735 C  CG1 . VAL A 113 ? 0.28980 0.18259 0.20010 0.01980  -0.03300 -0.00220 1572 VAL A CG1 
1736 C  CG2 . VAL A 113 ? 0.23650 0.13870 0.20630 0.01840  -0.02920 -0.03950 1572 VAL A CG2 
1746 N  N   . GLN A 114 ? 0.17950 0.11410 0.16200 0.00260  0.03080  -0.00670 1573 GLN A N   
1747 C  CA  . GLN A 114 ? 0.18600 0.12370 0.16790 -0.00370 0.04410  0.01330  1573 GLN A CA  
1748 C  C   . GLN A 114 ? 0.15920 0.11450 0.15170 -0.01190 0.03610  0.01230  1573 GLN A C   
1749 O  O   . GLN A 114 ? 0.17400 0.10810 0.17390 -0.00110 0.02490  0.00800  1573 GLN A O   
1750 C  CB  . GLN A 114 ? 0.19820 0.15290 0.17850 -0.02250 0.04610  0.02130  1573 GLN A CB  
1751 C  CG  . GLN A 114 ? 0.24880 0.20380 0.27920 -0.04550 0.08500  0.01110  1573 GLN A CG  
1752 C  CD  . GLN A 114 ? 0.30410 0.26190 0.33150 -0.02670 0.09990  0.02400  1573 GLN A CD  
1753 O  OE1 . GLN A 114 ? 0.31160 0.27789 0.36160 -0.02030 0.08780  -0.01390 1573 GLN A OE1 
1754 N  NE2 . GLN A 114 ? 0.35240 0.29169 0.42310 -0.03540 0.08620  0.05170  1573 GLN A NE2 
1763 N  N   . TRP A 115 ? 0.14690 0.12800 0.13970 -0.00980 0.00850  0.01550  1574 TRP A N   
1764 C  CA  . TRP A 115 ? 0.12630 0.12540 0.14440 -0.00700 0.00510  0.00680  1574 TRP A CA  
1765 C  C   . TRP A 115 ? 0.13470 0.13470 0.15140 -0.00600 -0.00460 -0.00390 1574 TRP A C   
1766 O  O   . TRP A 115 ? 0.12680 0.14150 0.17510 0.00670  0.01180  -0.00720 1574 TRP A O   
1767 C  CB  . TRP A 115 ? 0.12600 0.13510 0.14600 0.00130  -0.00590 -0.00230 1574 TRP A CB  
1768 C  CG  . TRP A 115 ? 0.12410 0.13120 0.11820 -0.00020 0.01290  -0.01550 1574 TRP A CG  
1769 C  CD1 . TRP A 115 ? 0.14860 0.13640 0.15550 0.00740  0.00590  0.00520  1574 TRP A CD1 
1770 C  CD2 . TRP A 115 ? 0.11450 0.13090 0.11320 0.00510  0.00430  0.00080  1574 TRP A CD2 
1771 N  NE1 . TRP A 115 ? 0.14010 0.14769 0.15080 0.00580  0.01570  0.01380  1574 TRP A NE1 
1772 C  CE2 . TRP A 115 ? 0.12770 0.13180 0.12600 0.00760  -0.00510 -0.00580 1574 TRP A CE2 
1773 C  CE3 . TRP A 115 ? 0.13230 0.12940 0.13050 0.01820  0.01490  -0.00420 1574 TRP A CE3 
1774 C  CZ2 . TRP A 115 ? 0.13180 0.13910 0.14360 0.00990  0.00680  -0.01200 1574 TRP A CZ2 
1775 C  CZ3 . TRP A 115 ? 0.14690 0.13080 0.13820 0.00950  -0.00720 -0.00560 1574 TRP A CZ3 
1776 C  CH2 . TRP A 115 ? 0.14070 0.13790 0.15160 0.00810  -0.00120 -0.01520 1574 TRP A CH2 
1787 N  N   . MET A 116 ? 0.14770 0.12760 0.14560 -0.00640 -0.02840 -0.01170 1575 MET A N   
1788 C  CA  A MET A 116 ? 0.16870 0.13780 0.16510 -0.01630 -0.03350 0.00480  1575 MET A CA  
1789 C  CA  B MET A 116 ? 0.15060 0.13170 0.14170 -0.00810 -0.03480 -0.00210 1575 MET A CA  
1790 C  C   . MET A 116 ? 0.16120 0.12680 0.14840 -0.01220 -0.01870 0.00700  1575 MET A C   
1791 O  O   . MET A 116 ? 0.15370 0.13230 0.18570 -0.01070 -0.00960 0.00980  1575 MET A O   
1792 C  CB  A MET A 116 ? 0.17590 0.14850 0.20060 -0.02530 -0.03560 0.02130  1575 MET A CB  
1793 C  CB  B MET A 116 ? 0.12470 0.13040 0.13130 0.00240  -0.03760 0.00100  1575 MET A CB  
1794 C  CG  A MET A 116 ? 0.22810 0.16330 0.26610 -0.05200 -0.04510 0.02920  1575 MET A CG  
1795 C  CG  B MET A 116 ? 0.15050 0.13330 0.12590 -0.00760 -0.01420 -0.00840 1575 MET A CG  
1796 S  SD  A MET A 116 ? 0.26949 0.16869 0.33159 -0.06170 -0.03800 0.03370  1575 MET A SD  
1797 S  SD  B MET A 116 ? 0.17300 0.14019 0.18440 -0.01450 0.00310  -0.00070 1575 MET A SD  
1798 C  CE  A MET A 116 ? 0.21690 0.13600 0.25740 -0.08390 -0.02740 0.04810  1575 MET A CE  
1799 C  CE  B MET A 116 ? 0.17550 0.12140 0.16190 -0.01650 0.00790  -0.00090 1575 MET A CE  
1818 N  N   . GLU A 117 ? 0.16710 0.12420 0.13730 -0.00970 -0.00990 0.01900  1576 GLU A N   
1819 C  CA  . GLU A 117 ? 0.17910 0.12900 0.13900 0.00060  -0.02320 -0.00130 1576 GLU A CA  
1820 C  C   . GLU A 117 ? 0.17060 0.12880 0.11890 -0.01160 -0.02510 0.00570  1576 GLU A C   
1821 O  O   . GLU A 117 ? 0.15970 0.13440 0.19220 -0.00120 -0.03360 0.02780  1576 GLU A O   
1822 C  CB  . GLU A 117 ? 0.20950 0.13780 0.14390 -0.00010 -0.00560 0.00470  1576 GLU A CB  
1823 C  CG  . GLU A 117 ? 0.26480 0.15560 0.18370 0.00080  -0.00210 -0.00000 1576 GLU A CG  
1824 C  CD  . GLU A 117 ? 0.29810 0.18510 0.19470 -0.01380 0.02150  -0.03130 1576 GLU A CD  
1825 O  OE1 . GLU A 117 ? 0.28850 0.20099 0.23470 -0.02490 0.03230  -0.03060 1576 GLU A OE1 
1826 O  OE2 . GLU A 117 ? 0.35799 0.21299 0.18940 -0.03670 0.03230  -0.02650 1576 GLU A OE2 
1833 N  N   . HIS A 118 ? 0.15890 0.12690 0.13670 -0.00940 -0.00840 0.00060  1577 HIS A N   
1834 C  CA  . HIS A 118 ? 0.16130 0.12760 0.10500 -0.02560 0.00800  -0.00370 1577 HIS A CA  
1835 C  C   . HIS A 118 ? 0.16020 0.13430 0.15100 -0.01830 0.00220  0.01290  1577 HIS A C   
1836 O  O   . HIS A 118 ? 0.16000 0.13370 0.17390 0.00990  -0.02180 0.00630  1577 HIS A O   
1837 C  CB  . HIS A 118 ? 0.16700 0.12510 0.11030 -0.03010 0.00070  -0.00880 1577 HIS A CB  
1838 C  CG  . HIS A 118 ? 0.15570 0.13800 0.15340 -0.02100 -0.01140 0.00630  1577 HIS A CG  
1839 N  ND1 . HIS A 118 ? 0.17070 0.14380 0.14460 -0.01840 -0.00220 0.03020  1577 HIS A ND1 
1840 C  CD2 . HIS A 118 ? 0.18130 0.15679 0.16940 -0.02920 0.01300  -0.00730 1577 HIS A CD2 
1841 C  CE1 . HIS A 118 ? 0.17330 0.15170 0.13570 -0.02830 -0.01220 0.03860  1577 HIS A CE1 
1842 N  NE2 . HIS A 118 ? 0.16150 0.15840 0.15320 -0.03040 -0.00190 0.01810  1577 HIS A NE2 
1850 N  N   . PHE A 119 ? 0.14680 0.13890 0.17190 -0.01720 -0.00270 0.02030  1578 PHE A N   
1851 C  CA  . PHE A 119 ? 0.12660 0.13280 0.16710 -0.01670 -0.00260 0.01180  1578 PHE A CA  
1852 C  C   . PHE A 119 ? 0.13080 0.14310 0.16700 -0.02560 -0.00790 0.01170  1578 PHE A C   
1853 O  O   . PHE A 119 ? 0.14330 0.14950 0.18180 -0.01120 -0.02370 0.01250  1578 PHE A O   
1854 C  CB  . PHE A 119 ? 0.14870 0.12150 0.17010 -0.01620 0.00910  -0.01730 1578 PHE A CB  
1855 C  CG  . PHE A 119 ? 0.15900 0.11750 0.13360 -0.00100 -0.00900 -0.00500 1578 PHE A CG  
1856 C  CD1 . PHE A 119 ? 0.17330 0.14060 0.10330 -0.01380 -0.00610 -0.00390 1578 PHE A CD1 
1857 C  CD2 . PHE A 119 ? 0.16570 0.10720 0.12020 -0.00460 0.02110  0.00940  1578 PHE A CD2 
1858 C  CE1 . PHE A 119 ? 0.16300 0.15189 0.14050 0.00590  0.00670  -0.00340 1578 PHE A CE1 
1859 C  CE2 . PHE A 119 ? 0.14810 0.12370 0.13530 -0.00340 0.00350  0.00810  1578 PHE A CE2 
1860 C  CZ  . PHE A 119 ? 0.15100 0.14200 0.13030 0.01230  -0.00220 0.00910  1578 PHE A CZ  
1870 N  N   . GLU A 120 ? 0.13950 0.15010 0.15680 -0.00380 -0.02080 -0.00010 1579 GLU A N   
1871 C  CA  . GLU A 120 ? 0.18090 0.15270 0.17120 -0.00900 -0.01560 0.00070  1579 GLU A CA  
1872 C  C   . GLU A 120 ? 0.16670 0.15130 0.22750 -0.00010 -0.00880 0.01690  1579 GLU A C   
1873 O  O   . GLU A 120 ? 0.17400 0.16829 0.31150 0.00360  -0.03660 0.03940  1579 GLU A O   
1874 C  CB  . GLU A 120 ? 0.21570 0.15760 0.17310 0.00130  -0.05660 0.00020  1579 GLU A CB  
1875 C  CG  . GLU A 120 ? 0.23330 0.16900 0.22830 -0.00520 -0.03610 -0.00890 1579 GLU A CG  
1876 C  CD  . GLU A 120 ? 0.28920 0.16760 0.24840 -0.01520 -0.00640 -0.01920 1579 GLU A CD  
1877 O  OE1 . GLU A 120 ? 0.33250 0.18370 0.24610 -0.00820 -0.01410 -0.03160 1579 GLU A OE1 
1878 O  OE2 . GLU A 120 ? 0.33620 0.16790 0.31600 -0.00300 0.00110  -0.02790 1579 GLU A OE2 
1885 N  N   . THR A 121 ? 0.18880 0.13960 0.18000 -0.01730 -0.04510 0.01500  1580 THR A N   
1886 C  CA  . THR A 121 ? 0.18230 0.12840 0.15480 -0.00830 -0.01580 0.01760  1580 THR A CA  
1887 C  C   . THR A 121 ? 0.17330 0.12690 0.15180 -0.00400 -0.02130 0.00440  1580 THR A C   
1888 O  O   . THR A 121 ? 0.19210 0.13570 0.19400 0.00260  -0.02960 0.01730  1580 THR A O   
1889 C  CB  . THR A 121 ? 0.20810 0.13650 0.17250 0.01140  -0.01090 0.01210  1580 THR A CB  
1890 O  OG1 . THR A 121 ? 0.19860 0.13250 0.18180 0.00240  -0.00570 0.01740  1580 THR A OG1 
1891 C  CG2 . THR A 121 ? 0.25270 0.15689 0.18630 0.01650  -0.02150 0.03370  1580 THR A CG2 
1899 N  N   . TRP A 122 ? 0.17620 0.13900 0.13700 -0.00140 -0.02830 -0.00430 1581 TRP A N   
1900 C  CA  . TRP A 122 ? 0.16440 0.14510 0.11410 -0.00390 -0.01630 0.00900  1581 TRP A CA  
1901 C  C   . TRP A 122 ? 0.15940 0.15300 0.15040 -0.00460 -0.02680 0.01290  1581 TRP A C   
1902 O  O   . TRP A 122 ? 0.15640 0.15990 0.19620 -0.01270 -0.01800 0.01040  1581 TRP A O   
1903 C  CB  . TRP A 122 ? 0.14130 0.14330 0.12190 -0.00820 -0.01620 0.00820  1581 TRP A CB  
1904 C  CG  . TRP A 122 ? 0.13490 0.13590 0.10700 0.00390  -0.02530 -0.00450 1581 TRP A CG  
1905 C  CD1 . TRP A 122 ? 0.13040 0.13390 0.13280 0.01070  0.00580  0.02070  1581 TRP A CD1 
1906 C  CD2 . TRP A 122 ? 0.13510 0.13430 0.14000 0.00520  -0.02280 0.01050  1581 TRP A CD2 
1907 N  NE1 . TRP A 122 ? 0.13750 0.13440 0.13120 0.00960  0.00550  0.01270  1581 TRP A NE1 
1908 C  CE2 . TRP A 122 ? 0.11370 0.13480 0.13770 0.01100  -0.00210 0.01490  1581 TRP A CE2 
1909 C  CE3 . TRP A 122 ? 0.14810 0.13140 0.15180 -0.01260 -0.00730 0.03130  1581 TRP A CE3 
1910 C  CZ2 . TRP A 122 ? 0.12430 0.12910 0.13610 0.01170  -0.02240 0.00870  1581 TRP A CZ2 
1911 C  CZ3 . TRP A 122 ? 0.16740 0.13250 0.16830 -0.02300 -0.00550 0.04090  1581 TRP A CZ3 
1912 C  CH2 . TRP A 122 ? 0.15640 0.12810 0.16390 -0.00420 -0.02180 0.03940  1581 TRP A CH2 
1923 N  N   . PRO A 123 ? 0.13250 0.14600 0.17710 -0.00360 -0.02140 0.02230  1582 PRO A N   
1924 C  CA  . PRO A 123 ? 0.13230 0.16330 0.18600 0.00040  -0.01870 -0.00090 1582 PRO A CA  
1925 C  C   . PRO A 123 ? 0.13420 0.17570 0.18260 -0.01810 -0.03350 -0.02280 1582 PRO A C   
1926 O  O   . PRO A 123 ? 0.13840 0.15770 0.18440 -0.01000 -0.03030 -0.00530 1582 PRO A O   
1927 C  CB  . PRO A 123 ? 0.12340 0.16780 0.19290 0.01180  -0.03350 0.00600  1582 PRO A CB  
1928 C  CG  . PRO A 123 ? 0.12200 0.16160 0.22330 0.01810  0.00150  0.01060  1582 PRO A CG  
1929 C  CD  . PRO A 123 ? 0.12340 0.15000 0.20640 0.00130  -0.00700 0.02380  1582 PRO A CD  
1937 N  N   . SER A 124 ? 0.16290 0.21470 0.20370 -0.04740 -0.01140 -0.02380 1583 SER A N   
1938 C  CA  . SER A 124 ? 0.21350 0.24320 0.22760 -0.07890 0.00250  -0.02280 1583 SER A CA  
1939 C  C   . SER A 124 ? 0.17540 0.22170 0.23020 -0.06910 0.02870  -0.00910 1583 SER A C   
1940 O  O   . SER A 124 ? 0.22470 0.21460 0.27400 -0.07030 0.04260  -0.00200 1583 SER A O   
1941 C  CB  . SER A 124 ? 0.27619 0.29330 0.31700 -0.09810 0.00390  -0.03890 1583 SER A CB  
1942 O  OG  . SER A 124 ? 0.27500 0.32959 0.34870 -0.11960 -0.03800 -0.04600 1583 SER A OG  
1948 N  N   . HIS A 125 ? 0.12640 0.21190 0.22750 -0.04700 0.00730  -0.00840 1584 HIS A N   
1949 C  CA  . HIS A 125 ? 0.13090 0.20170 0.21520 -0.02350 -0.00130 -0.00310 1584 HIS A CA  
1950 C  C   . HIS A 125 ? 0.12530 0.17200 0.18930 -0.01900 -0.00450 0.02290  1584 HIS A C   
1951 O  O   . HIS A 125 ? 0.13960 0.18939 0.20580 -0.03080 0.01550  0.04500  1584 HIS A O   
1952 C  CB  . HIS A 125 ? 0.14370 0.22110 0.23240 -0.00450 -0.00470 0.01360  1584 HIS A CB  
1953 C  CG  . HIS A 125 ? 0.14720 0.22980 0.19960 0.02150  -0.00780 0.02960  1584 HIS A CG  
1954 N  ND1 . HIS A 125 ? 0.15190 0.22940 0.22380 0.01780  -0.01300 0.02950  1584 HIS A ND1 
1955 C  CD2 . HIS A 125 ? 0.15050 0.23660 0.19020 0.03030  0.02410  0.01790  1584 HIS A CD2 
1956 C  CE1 . HIS A 125 ? 0.16740 0.22840 0.23050 0.03620  0.00340  0.02870  1584 HIS A CE1 
1957 N  NE2 . HIS A 125 ? 0.14630 0.23630 0.18580 0.03260  0.00180  0.02530  1584 HIS A NE2 
1965 N  N   . LEU A 126 ? 0.10400 0.12620 0.20100 -0.00460 -0.00640 -0.00220 1585 LEU A N   
1966 C  CA  . LEU A 126 ? 0.11840 0.11090 0.16960 -0.00390 -0.00260 0.01790  1585 LEU A CA  
1967 C  C   . LEU A 126 ? 0.10650 0.11370 0.16640 -0.00720 -0.00950 0.01420  1585 LEU A C   
1968 O  O   . LEU A 126 ? 0.13810 0.11300 0.15600 -0.00630 -0.01620 0.00760  1585 LEU A O   
1969 C  CB  . LEU A 126 ? 0.13250 0.11580 0.15060 -0.00460 -0.02460 0.03140  1585 LEU A CB  
1970 C  CG  . LEU A 126 ? 0.13730 0.12950 0.17180 0.00200  0.00210  0.02500  1585 LEU A CG  
1971 C  CD1 . LEU A 126 ? 0.15810 0.13920 0.15060 0.00510  -0.01310 0.01420  1585 LEU A CD1 
1972 C  CD2 . LEU A 126 ? 0.14520 0.12360 0.21600 -0.00210 0.02160  0.03330  1585 LEU A CD2 
1984 N  N   . PRO A 127 ? 0.11840 0.11310 0.16200 -0.00050 -0.00910 0.01400  1586 PRO A N   
1985 C  CA  . PRO A 127 ? 0.13490 0.11870 0.13410 -0.00060 -0.01360 0.01120  1586 PRO A CA  
1986 C  C   . PRO A 127 ? 0.12240 0.11630 0.15140 -0.00570 -0.01620 0.01650  1586 PRO A C   
1987 O  O   . PRO A 127 ? 0.12030 0.11200 0.14860 -0.00250 0.00060  0.00760  1586 PRO A O   
1988 C  CB  . PRO A 127 ? 0.14140 0.12220 0.12410 0.00250  -0.00860 -0.00540 1586 PRO A CB  
1989 C  CG  . PRO A 127 ? 0.12100 0.12620 0.16040 0.00220  0.00150  -0.01490 1586 PRO A CG  
1990 C  CD  . PRO A 127 ? 0.10660 0.11680 0.17170 -0.00100 0.01480  -0.00400 1586 PRO A CD  
1998 N  N   . ILE A 128 ? 0.09800 0.10630 0.16240 -0.00250 -0.01170 0.00890  1587 ILE A N   
1999 C  CA  . ILE A 128 ? 0.09800 0.11120 0.13830 -0.00230 -0.00500 0.01510  1587 ILE A CA  
2000 C  C   . ILE A 128 ? 0.10460 0.11110 0.12790 0.00640  0.02820  0.01020  1587 ILE A C   
2001 O  O   . ILE A 128 ? 0.11230 0.11580 0.12930 -0.00200 0.00380  0.02670  1587 ILE A O   
2002 C  CB  . ILE A 128 ? 0.12150 0.12020 0.15150 -0.00680 -0.00220 0.00220  1587 ILE A CB  
2003 C  CG1 . ILE A 128 ? 0.14080 0.14630 0.15340 -0.01610 -0.01660 -0.01500 1587 ILE A CG1 
2004 C  CG2 . ILE A 128 ? 0.13220 0.12100 0.22760 -0.01100 -0.00360 -0.02040 1587 ILE A CG2 
2005 C  CD1 . ILE A 128 ? 0.15340 0.16379 0.17480 -0.00910 -0.02240 -0.02620 1587 ILE A CD1 
2017 N  N   . VAL A 129 ? 0.09040 0.10130 0.15210 -0.00440 -0.01140 0.01110  1588 VAL A N   
2018 C  CA  . VAL A 129 ? 0.11360 0.11570 0.17130 0.00600  -0.00310 0.01170  1588 VAL A CA  
2019 C  C   . VAL A 129 ? 0.10560 0.11130 0.13640 -0.01630 -0.00300 0.01320  1588 VAL A C   
2020 O  O   . VAL A 129 ? 0.11620 0.09880 0.17000 0.00570  0.01010  0.01590  1588 VAL A O   
2021 C  CB  . VAL A 129 ? 0.10830 0.12350 0.16240 0.01870  0.00430  0.01400  1588 VAL A CB  
2022 C  CG1 . VAL A 129 ? 0.12770 0.11540 0.14830 0.01360  0.01350  -0.00110 1588 VAL A CG1 
2023 C  CG2 . VAL A 129 ? 0.11930 0.15459 0.16820 -0.01510 0.02090  -0.02760 1588 VAL A CG2 
2033 N  N   . ALA A 130 ? 0.10590 0.11820 0.11820 0.00200  -0.00970 0.01770  1589 ALA A N   
2034 C  CA  . ALA A 130 ? 0.10460 0.11240 0.13290 0.01120  0.01390  -0.00720 1589 ALA A CA  
2035 C  C   . ALA A 130 ? 0.10930 0.10780 0.11960 0.00510  0.00800  -0.01720 1589 ALA A C   
2036 O  O   . ALA A 130 ? 0.10660 0.10850 0.14180 0.01490  0.00570  -0.00980 1589 ALA A O   
2037 C  CB  . ALA A 130 ? 0.12600 0.11320 0.13430 -0.00450 -0.00340 -0.00690 1589 ALA A CB  
2043 N  N   . HIS A 131 ? 0.09550 0.11220 0.14020 0.00920  0.00420  0.00970  1590 HIS A N   
2044 C  CA  . HIS A 131 ? 0.10090 0.10570 0.13040 0.00470  0.00270  0.00650  1590 HIS A CA  
2045 C  C   . HIS A 131 ? 0.11470 0.10980 0.09390 0.01280  0.01040  -0.00870 1590 HIS A C   
2046 O  O   . HIS A 131 ? 0.11530 0.11410 0.12790 0.00500  -0.00760 -0.01210 1590 HIS A O   
2047 C  CB  . HIS A 131 ? 0.09880 0.11590 0.12950 -0.00770 0.00060  -0.02340 1590 HIS A CB  
2048 C  CG  . HIS A 131 ? 0.09700 0.11930 0.14590 -0.00490 -0.00400 -0.01190 1590 HIS A CG  
2049 N  ND1 . HIS A 131 ? 0.10550 0.12679 0.14300 -0.00850 0.00230  -0.00880 1590 HIS A ND1 
2050 C  CD2 . HIS A 131 ? 0.10440 0.12580 0.15500 -0.01160 -0.00870 -0.01270 1590 HIS A CD2 
2051 C  CE1 . HIS A 131 ? 0.06890 0.13250 0.20060 0.00790  -0.01070 0.00910  1590 HIS A CE1 
2052 N  NE2 . HIS A 131 ? 0.09300 0.13650 0.18730 -0.00890 -0.00580 0.00370  1590 HIS A NE2 
2060 N  N   . ALA A 132 ? 0.10740 0.10300 0.11140 -0.00530 0.00040  -0.01330 1591 ALA A N   
2061 C  CA  . ALA A 132 ? 0.12440 0.10950 0.14030 0.00440  0.01290  -0.01370 1591 ALA A CA  
2062 C  C   . ALA A 132 ? 0.12210 0.13050 0.16260 0.01210  0.00700  0.00380  1591 ALA A C   
2063 O  O   . ALA A 132 ? 0.16010 0.16249 0.20180 0.05540  0.04630  0.04310  1591 ALA A O   
2064 C  CB  . ALA A 132 ? 0.13360 0.10480 0.15890 -0.00640 -0.01000 -0.01290 1591 ALA A CB  
2070 N  N   . GLU A 133 ? 0.10780 0.12010 0.14920 0.01260  -0.00940 -0.00060 1592 GLU A N   
2071 C  CA  . GLU A 133 ? 0.12849 0.12110 0.13210 0.00780  -0.01310 -0.01910 1592 GLU A CA  
2072 C  C   . GLU A 133 ? 0.10830 0.12550 0.14800 0.00580  -0.01700 -0.01050 1592 GLU A C   
2073 O  O   . GLU A 133 ? 0.12640 0.12610 0.12730 0.00350  -0.01590 -0.00920 1592 GLU A O   
2074 C  CB  . GLU A 133 ? 0.10430 0.12480 0.18340 0.01160  -0.03740 -0.02410 1592 GLU A CB  
2075 C  CG  . GLU A 133 ? 0.09270 0.12830 0.21900 0.00760  -0.03090 -0.01910 1592 GLU A CG  
2076 C  CD  . GLU A 133 ? 0.11780 0.13000 0.19240 -0.00120 -0.01930 0.00560  1592 GLU A CD  
2077 O  OE1 . GLU A 133 ? 0.13370 0.14799 0.21170 -0.01300 -0.03890 0.02800  1592 GLU A OE1 
2078 O  OE2 . GLU A 133 ? 0.11490 0.13830 0.23220 -0.00000 -0.01940 0.01330  1592 GLU A OE2 
2085 N  N   . GLN A 134 ? 0.13080 0.12480 0.18450 0.00940  -0.00310 -0.01430 1593 GLN A N   
2086 C  CA  . GLN A 134 ? 0.14070 0.12140 0.19280 0.00460  -0.01200 -0.00710 1593 GLN A CA  
2087 C  C   . GLN A 134 ? 0.14430 0.11100 0.21400 0.00240  -0.01100 0.00760  1593 GLN A C   
2088 O  O   . GLN A 134 ? 0.14840 0.11820 0.19580 0.01260  0.01720  0.00240  1593 GLN A O   
2089 C  CB  . GLN A 134 ? 0.14940 0.13310 0.21200 0.00380  -0.03530 -0.00470 1593 GLN A CB  
2090 C  CG  . GLN A 134 ? 0.14080 0.14580 0.25110 0.00930  -0.04320 0.01510  1593 GLN A CG  
2091 C  CD  . GLN A 134 ? 0.18360 0.19180 0.26350 0.00840  -0.05340 0.03660  1593 GLN A CD  
2092 O  OE1 . GLN A 134 ? 0.19300 0.23009 0.28050 0.01950  0.00480  0.03400  1593 GLN A OE1 
2093 N  NE2 . GLN A 134 ? 0.18820 0.18790 0.28380 0.02090  -0.05760 0.01860  1593 GLN A NE2 
2102 N  N   . GLN A 135 ? 0.13070 0.10561 0.21210 0.01340  -0.02200 -0.00400 1594 GLN A N   
2103 C  CA  . GLN A 135 ? 0.16150 0.16670 0.23500 0.01380  -0.04310 -0.01490 1594 GLN A CA  
2104 C  C   . GLN A 135 ? 0.13350 0.11850 0.19550 0.01100  -0.01880 -0.01520 1594 GLN A C   
2105 O  O   . GLN A 135 ? 0.13820 0.10540 0.20380 0.00800  -0.02380 -0.03010 1594 GLN A O   
2106 C  CB  . GLN A 135 ? 0.35909 0.31238 0.37159 0.00560  -0.00770 -0.00300 1594 GLN A CB  
2107 C  CG  . GLN A 135 ? 0.37860 0.37299 0.37730 0.00440  0.00050  -0.00460 1594 GLN A CG  
2108 C  CD  . GLN A 135 ? 0.37670 0.38279 0.38090 0.00500  0.00120  0.00100  1594 GLN A CD  
2109 O  OE1 . GLN A 135 ? 0.36770 0.36350 0.37350 0.00340  0.00240  -0.00320 1594 GLN A OE1 
2110 N  NE2 . GLN A 135 ? 0.38240 0.38210 0.38140 0.00090  0.00090  -0.00340 1594 GLN A NE2 
2119 N  N   . THR A 136 ? 0.12290 0.10140 0.18800 0.00680  -0.01890 -0.02010 1595 THR A N   
2120 C  CA  . THR A 136 ? 0.13190 0.11120 0.16310 0.00140  -0.01640 -0.01770 1595 THR A CA  
2121 C  C   . THR A 136 ? 0.13620 0.10520 0.13280 0.00290  -0.03140 -0.01760 1595 THR A C   
2122 O  O   . THR A 136 ? 0.13390 0.09390 0.15640 -0.01040 -0.00910 0.00190  1595 THR A O   
2123 C  CB  . THR A 136 ? 0.13050 0.11880 0.14850 -0.01430 0.00520  -0.01960 1595 THR A CB  
2124 O  OG1 . THR A 136 ? 0.12920 0.11730 0.16500 -0.00570 -0.00900 -0.01330 1595 THR A OG1 
2125 C  CG2 . THR A 136 ? 0.16520 0.13000 0.12930 -0.01650 -0.00080 -0.02130 1595 THR A CG2 
2133 N  N   . VAL A 137 ? 0.13160 0.10500 0.16320 0.01220  -0.05270 -0.00520 1596 VAL A N   
2134 C  CA  A VAL A 137 ? 0.12430 0.10840 0.14300 0.01280  -0.03760 -0.01000 1596 VAL A CA  
2135 C  CA  B VAL A 137 ? 0.11920 0.11230 0.14640 0.01090  -0.04410 -0.01180 1596 VAL A CA  
2136 C  C   . VAL A 137 ? 0.12400 0.10710 0.15280 0.01180  -0.04070 -0.01200 1596 VAL A C   
2137 O  O   . VAL A 137 ? 0.12910 0.09790 0.15040 0.00600  -0.01950 0.00340  1596 VAL A O   
2138 C  CB  A VAL A 137 ? 0.12350 0.10790 0.14720 0.02040  -0.02500 -0.01920 1596 VAL A CB  
2139 C  CB  B VAL A 137 ? 0.12500 0.12340 0.18350 0.01690  -0.02540 -0.02570 1596 VAL A CB  
2140 C  CG1 A VAL A 137 ? 0.11600 0.11870 0.15740 0.01460  -0.00800 -0.01360 1596 VAL A CG1 
2141 C  CG1 B VAL A 137 ? 0.15900 0.12560 0.19450 0.00630  0.02060  -0.00680 1596 VAL A CG1 
2142 C  CG2 A VAL A 137 ? 0.13860 0.09470 0.18880 0.02230  -0.02000 -0.01480 1596 VAL A CG2 
2143 C  CG2 B VAL A 137 ? 0.13710 0.12880 0.20510 0.01830  -0.03060 -0.03380 1596 VAL A CG2 
2162 N  N   . ALA A 138 ? 0.11760 0.10550 0.16620 0.00450  -0.02510 -0.00070 1597 ALA A N   
2163 C  CA  . ALA A 138 ? 0.11030 0.10450 0.18030 0.00350  -0.02690 -0.01220 1597 ALA A CA  
2164 C  C   . ALA A 138 ? 0.13010 0.09040 0.16780 0.00190  -0.02070 -0.00900 1597 ALA A C   
2165 O  O   . ALA A 138 ? 0.12290 0.09470 0.16290 0.00100  -0.02090 -0.01500 1597 ALA A O   
2166 C  CB  . ALA A 138 ? 0.14010 0.10740 0.18960 0.00000  -0.03700 0.00500  1597 ALA A CB  
2172 N  N   . ALA A 139 ? 0.12180 0.09870 0.15940 -0.00100 0.00080  -0.01070 1598 ALA A N   
2173 C  CA  . ALA A 139 ? 0.10170 0.10000 0.15340 0.00360  -0.00000 -0.01430 1598 ALA A CA  
2174 C  C   . ALA A 139 ? 0.12899 0.10780 0.13180 0.00450  -0.00920 -0.01180 1598 ALA A C   
2175 O  O   . ALA A 139 ? 0.11910 0.11050 0.16140 0.00460  -0.00770 -0.00570 1598 ALA A O   
2176 C  CB  . ALA A 139 ? 0.10400 0.08850 0.20840 0.00580  -0.01410 -0.01880 1598 ALA A CB  
2182 N  N   . VAL A 140 ? 0.10520 0.10530 0.16200 -0.00340 0.00250  -0.01340 1599 VAL A N   
2183 C  CA  . VAL A 140 ? 0.12120 0.10700 0.15050 -0.00100 -0.00820 -0.00430 1599 VAL A CA  
2184 C  C   . VAL A 140 ? 0.11290 0.09980 0.14290 0.00200  0.00120  0.00560  1599 VAL A C   
2185 O  O   . VAL A 140 ? 0.11080 0.09840 0.16960 0.00430  -0.00860 0.00440  1599 VAL A O   
2186 C  CB  . VAL A 140 ? 0.10250 0.10850 0.16660 0.00310  -0.01230 -0.00460 1599 VAL A CB  
2187 C  CG1 . VAL A 140 ? 0.13130 0.10190 0.17040 0.00440  -0.02000 -0.01080 1599 VAL A CG1 
2188 C  CG2 . VAL A 140 ? 0.13440 0.10670 0.17010 -0.00100 -0.00810 0.01070  1599 VAL A CG2 
2198 N  N   . LEU A 141 ? 0.09970 0.11410 0.12920 0.00290  0.00390  0.00380  1600 LEU A N   
2199 C  CA  . LEU A 141 ? 0.12460 0.13170 0.08770 0.00980  -0.00400 -0.01200 1600 LEU A CA  
2200 C  C   . LEU A 141 ? 0.12540 0.11490 0.12620 0.00120  0.00030  -0.00880 1600 LEU A C   
2201 O  O   . LEU A 141 ? 0.10280 0.10940 0.18780 0.00310  -0.00800 0.00510  1600 LEU A O   
2202 C  CB  . LEU A 141 ? 0.13770 0.17090 0.07730 0.01710  0.00330  0.00270  1600 LEU A CB  
2203 C  CG  . LEU A 141 ? 0.19870 0.19730 0.13710 0.00240  0.01180  -0.00490 1600 LEU A CG  
2204 C  CD1 . LEU A 141 ? 0.25130 0.21879 0.08820 -0.00330 -0.00890 -0.01100 1600 LEU A CD1 
2205 C  CD2 . LEU A 141 ? 0.25150 0.20210 0.24149 0.02880  0.08490  -0.03050 1600 LEU A CD2 
2217 N  N   A MET A 142 ? 0.12790 0.10340 0.14320 -0.00250 -0.02230 -0.01110 1601 MET A N   
2218 N  N   B MET A 142 ? 0.14430 0.12540 0.14530 -0.00280 -0.00280 -0.00560 1601 MET A N   
2219 C  CA  A MET A 142 ? 0.11610 0.09880 0.15480 0.00590  -0.00380 -0.02800 1601 MET A CA  
2220 C  CA  B MET A 142 ? 0.15440 0.13410 0.16670 -0.00350 -0.00310 -0.00650 1601 MET A CA  
2221 C  C   A MET A 142 ? 0.10070 0.10140 0.14660 0.01260  -0.01480 -0.01530 1601 MET A C   
2222 C  C   B MET A 142 ? 0.13150 0.12850 0.14930 0.00160  -0.00140 -0.00020 1601 MET A C   
2223 O  O   A MET A 142 ? 0.11590 0.09360 0.17030 0.00910  -0.03170 -0.01180 1601 MET A O   
2224 O  O   B MET A 142 ? 0.14160 0.12860 0.14660 0.00270  -0.00570 0.00180  1601 MET A O   
2225 C  CB  A MET A 142 ? 0.12020 0.11020 0.17090 0.00750  -0.03280 -0.03020 1601 MET A CB  
2226 C  CB  B MET A 142 ? 0.17780 0.14750 0.20030 -0.00960 -0.01620 -0.00910 1601 MET A CB  
2227 C  CG  A MET A 142 ? 0.13110 0.11580 0.16160 0.01120  -0.02680 -0.01050 1601 MET A CG  
2228 C  CG  B MET A 142 ? 0.18340 0.15870 0.20600 -0.01800 -0.03920 -0.01120 1601 MET A CG  
2229 S  SD  A MET A 142 ? 0.14010 0.12370 0.22950 -0.01040 -0.01550 0.00960  1601 MET A SD  
2230 S  SD  B MET A 142 ? 0.17140 0.17090 0.17210 -0.03610 -0.07880 -0.01230 1601 MET A SD  
2231 C  CE  A MET A 142 ? 0.17400 0.14629 0.26640 -0.02490 -0.02010 0.01320  1601 MET A CE  
2232 C  CE  B MET A 142 ? 0.21420 0.17500 0.25200 -0.03460 -0.04200 -0.00060 1601 MET A CE  
2251 N  N   . VAL A 143 ? 0.09750 0.12140 0.14640 0.00510  0.00290  0.00620  1602 VAL A N   
2252 C  CA  . VAL A 143 ? 0.11430 0.12590 0.14620 0.00210  -0.01060 0.01540  1602 VAL A CA  
2253 C  C   . VAL A 143 ? 0.12720 0.11250 0.12130 -0.00420 -0.03080 0.01280  1602 VAL A C   
2254 O  O   . VAL A 143 ? 0.12710 0.10440 0.16400 -0.00720 -0.02560 0.01280  1602 VAL A O   
2255 C  CB  . VAL A 143 ? 0.13410 0.13690 0.15490 -0.00940 -0.00430 0.02180  1602 VAL A CB  
2256 C  CG1 . VAL A 143 ? 0.13030 0.14260 0.17200 -0.00110 0.00430  0.01970  1602 VAL A CG1 
2257 C  CG2 . VAL A 143 ? 0.13620 0.15539 0.17720 0.00200  0.01040  0.00650  1602 VAL A CG2 
2267 N  N   . ALA A 144 ? 0.11900 0.10590 0.16510 0.00290  -0.00640 -0.00040 1603 ALA A N   
2268 C  CA  . ALA A 144 ? 0.11820 0.11670 0.17790 0.00850  -0.00740 -0.00250 1603 ALA A CA  
2269 C  C   . ALA A 144 ? 0.11760 0.11990 0.16940 0.00270  0.00450  -0.01320 1603 ALA A C   
2270 O  O   . ALA A 144 ? 0.12230 0.12870 0.14190 0.01600  -0.01580 -0.01160 1603 ALA A O   
2271 C  CB  . ALA A 144 ? 0.12810 0.11580 0.19020 0.01310  -0.01250 -0.01460 1603 ALA A CB  
2277 N  N   . GLN A 145 ? 0.10960 0.11100 0.19950 0.00050  -0.00900 -0.01170 1604 GLN A N   
2278 C  CA  . GLN A 145 ? 0.12710 0.12320 0.18910 -0.00180 0.01100  -0.02740 1604 GLN A CA  
2279 C  C   . GLN A 145 ? 0.13940 0.13080 0.18020 -0.00860 -0.01420 -0.03120 1604 GLN A C   
2280 O  O   . GLN A 145 ? 0.11260 0.13670 0.19570 0.00720  -0.01190 -0.03330 1604 GLN A O   
2281 C  CB  . GLN A 145 ? 0.12180 0.13470 0.21920 -0.00370 0.00770  -0.03350 1604 GLN A CB  
2282 C  CG  . GLN A 145 ? 0.16970 0.14880 0.23900 0.01410  -0.00940 -0.00650 1604 GLN A CG  
2283 C  CD  . GLN A 145 ? 0.16270 0.16930 0.25630 0.00140  -0.00010 0.00150  1604 GLN A CD  
2284 O  OE1 . GLN A 145 ? 0.17620 0.17520 0.26490 0.00820  0.01350  0.01060  1604 GLN A OE1 
2285 N  NE2 . GLN A 145 ? 0.16010 0.16850 0.22410 -0.00460 0.01240  -0.03430 1604 GLN A NE2 
2294 N  N   . LEU A 146 ? 0.15150 0.14580 0.18060 -0.01660 0.00990  -0.02770 1605 LEU A N   
2295 C  CA  . LEU A 146 ? 0.14670 0.14859 0.19790 -0.02410 0.00800  -0.01300 1605 LEU A CA  
2296 C  C   . LEU A 146 ? 0.16840 0.14080 0.21880 -0.02400 -0.01120 -0.03660 1605 LEU A C   
2297 O  O   . LEU A 146 ? 0.22140 0.13900 0.22180 -0.01870 -0.03180 -0.01600 1605 LEU A O   
2298 C  CB  . LEU A 146 ? 0.17410 0.14180 0.19280 -0.01320 0.00280  -0.02690 1605 LEU A CB  
2299 C  CG  . LEU A 146 ? 0.17070 0.13990 0.22650 -0.00550 -0.01040 -0.03720 1605 LEU A CG  
2300 C  CD1 . LEU A 146 ? 0.17830 0.14890 0.21710 0.03080  0.00110  -0.01650 1605 LEU A CD1 
2301 C  CD2 . LEU A 146 ? 0.21730 0.14230 0.25090 0.00040  -0.03990 -0.04790 1605 LEU A CD2 
2313 N  N   . THR A 147 ? 0.20200 0.14110 0.21830 -0.02060 -0.02580 -0.02610 1606 THR A N   
2314 C  CA  . THR A 147 ? 0.20040 0.14460 0.23680 0.01450  -0.04930 -0.00900 1606 THR A CA  
2315 C  C   . THR A 147 ? 0.20900 0.15220 0.25240 0.01670  -0.03100 0.00820  1606 THR A C   
2316 O  O   . THR A 147 ? 0.21370 0.16140 0.30240 0.01300  -0.07290 0.02900  1606 THR A O   
2317 C  CB  . THR A 147 ? 0.17320 0.13940 0.25440 -0.00890 -0.04780 0.00490  1606 THR A CB  
2318 O  OG1 . THR A 147 ? 0.15760 0.14080 0.24440 -0.02880 -0.03770 0.03080  1606 THR A OG1 
2319 C  CG2 . THR A 147 ? 0.18410 0.13660 0.30510 -0.01950 -0.01920 0.00700  1606 THR A CG2 
2327 N  N   . GLN A 148 ? 0.19290 0.16050 0.25560 0.00150  -0.06220 -0.01460 1607 GLN A N   
2328 C  CA  . GLN A 148 ? 0.15430 0.17790 0.27260 0.00170  -0.08520 -0.04490 1607 GLN A CA  
2329 C  C   . GLN A 148 ? 0.15800 0.15840 0.26550 0.01050  -0.07530 -0.03830 1607 GLN A C   
2330 O  O   . GLN A 148 ? 0.16100 0.16970 0.32270 0.02110  -0.09080 -0.05660 1607 GLN A O   
2331 C  CB  . GLN A 148 ? 0.18670 0.22650 0.30980 -0.01820 -0.06580 -0.07690 1607 GLN A CB  
2332 C  CG  . GLN A 148 ? 0.23630 0.29840 0.34060 -0.03160 -0.07520 -0.08650 1607 GLN A CG  
2333 C  CD  . GLN A 148 ? 0.29530 0.36809 0.37290 -0.03900 -0.04930 -0.06440 1607 GLN A CD  
2334 O  OE1 . GLN A 148 ? 0.36619 0.39489 0.43520 -0.05340 -0.03210 -0.05270 1607 GLN A OE1 
2335 N  NE2 . GLN A 148 ? 0.33810 0.39509 0.39830 -0.02580 -0.08480 -0.05410 1607 GLN A NE2 
2344 N  N   . ARG A 149 ? 0.13210 0.13070 0.18340 0.00930  -0.03330 -0.01710 1608 ARG A N   
2345 C  CA  . ARG A 149 ? 0.12070 0.12780 0.17300 0.00470  -0.01950 -0.01790 1608 ARG A CA  
2346 C  C   . ARG A 149 ? 0.10410 0.12360 0.17610 -0.00090 -0.00150 -0.02290 1608 ARG A C   
2347 O  O   . ARG A 149 ? 0.11250 0.11940 0.19200 0.00070  -0.00940 -0.00780 1608 ARG A O   
2348 C  CB  . ARG A 149 ? 0.11710 0.13210 0.17460 -0.00210 -0.03030 0.00120  1608 ARG A CB  
2349 C  CG  . ARG A 149 ? 0.13070 0.13640 0.16160 -0.00840 -0.02330 0.01570  1608 ARG A CG  
2350 C  CD  . ARG A 149 ? 0.13690 0.14030 0.15660 -0.00820 0.00540  0.01290  1608 ARG A CD  
2351 N  NE  . ARG A 149 ? 0.13890 0.13580 0.17460 0.00300  -0.03440 -0.00440 1608 ARG A NE  
2352 C  CZ  . ARG A 149 ? 0.13450 0.13350 0.16210 0.00040  -0.00840 0.00500  1608 ARG A CZ  
2353 N  NH1 . ARG A 149 ? 0.15210 0.12560 0.17180 -0.00140 -0.03090 -0.00090 1608 ARG A NH1 
2354 N  NH2 . ARG A 149 ? 0.14320 0.12530 0.18030 -0.02110 -0.00350 -0.00870 1608 ARG A NH2 
2368 N  N   . SER A 150 ? 0.11590 0.12590 0.15850 -0.00270 -0.01260 -0.02070 1609 SER A N   
2369 C  CA  . SER A 150 ? 0.11040 0.11830 0.16910 0.00310  0.00150  -0.00410 1609 SER A CA  
2370 C  C   . SER A 150 ? 0.11980 0.10500 0.15680 -0.00430 -0.02050 0.00630  1609 SER A C   
2371 O  O   . SER A 150 ? 0.11630 0.11380 0.16490 -0.00070 -0.01320 0.00190  1609 SER A O   
2372 C  CB  . SER A 150 ? 0.12520 0.13889 0.14830 0.01170  0.00270  -0.00830 1609 SER A CB  
2373 O  OG  . SER A 150 ? 0.15300 0.13890 0.19950 0.01210  -0.00790 -0.00680 1609 SER A OG  
2379 N  N   . VAL A 151 ? 0.10320 0.11000 0.14090 -0.00430 -0.00940 0.00450  1610 VAL A N   
2380 C  CA  . VAL A 151 ? 0.10420 0.11760 0.12660 0.00110  -0.00050 0.00530  1610 VAL A CA  
2381 C  C   . VAL A 151 ? 0.10870 0.10390 0.13990 0.00230  -0.00530 0.00470  1610 VAL A C   
2382 O  O   . VAL A 151 ? 0.12360 0.09720 0.15620 -0.02100 -0.00790 -0.00060 1610 VAL A O   
2383 C  CB  . VAL A 151 ? 0.11280 0.13350 0.12460 0.00370  -0.00860 0.00230  1610 VAL A CB  
2384 C  CG1 . VAL A 151 ? 0.13160 0.13320 0.16920 0.00620  -0.02000 -0.00270 1610 VAL A CG1 
2385 C  CG2 . VAL A 151 ? 0.13910 0.13920 0.15380 -0.00600 0.00410  -0.01580 1610 VAL A CG2 
2395 N  N   . HIS A 152 ? 0.09510 0.09870 0.15160 -0.00610 -0.01280 -0.01080 1611 HIS A N   
2396 C  CA  . HIS A 152 ? 0.09090 0.09740 0.16040 -0.00660 0.00200  -0.01090 1611 HIS A CA  
2397 C  C   . HIS A 152 ? 0.09440 0.09690 0.13580 -0.01790 -0.00850 0.00710  1611 HIS A C   
2398 O  O   . HIS A 152 ? 0.10650 0.10580 0.15410 -0.01240 0.01040  0.00760  1611 HIS A O   
2399 C  CB  . HIS A 152 ? 0.10890 0.10240 0.12980 0.00160  -0.00800 0.00770  1611 HIS A CB  
2400 C  CG  . HIS A 152 ? 0.10750 0.09270 0.11740 0.00570  -0.00630 -0.00670 1611 HIS A CG  
2401 N  ND1 . HIS A 152 ? 0.12650 0.09710 0.11840 -0.00710 -0.00330 -0.01180 1611 HIS A ND1 
2402 C  CD2 . HIS A 152 ? 0.09650 0.08580 0.11790 0.00300  0.00260  -0.01110 1611 HIS A CD2 
2403 C  CE1 . HIS A 152 ? 0.12970 0.09300 0.13560 -0.01500 0.01630  -0.00210 1611 HIS A CE1 
2404 N  NE2 . HIS A 152 ? 0.12750 0.08830 0.14080 -0.00840 -0.00430 -0.00650 1611 HIS A NE2 
2412 N  N   . ILE A 153 ? 0.08250 0.10490 0.12720 -0.00310 -0.00650 0.00020  1612 ILE A N   
2413 C  CA  . ILE A 153 ? 0.09340 0.10320 0.11930 -0.00620 -0.00220 0.00060  1612 ILE A CA  
2414 C  C   . ILE A 153 ? 0.10520 0.10190 0.03800 0.01290  0.01220  0.01800  1612 ILE A C   
2415 O  O   . ILE A 153 ? 0.09060 0.11510 0.09950 -0.01890 0.01050  0.01290  1612 ILE A O   
2416 C  CB  . ILE A 153 ? 0.08310 0.10750 0.14570 -0.01820 0.00720  -0.01710 1612 ILE A CB  
2417 C  CG1 . ILE A 153 ? 0.10860 0.11470 0.16240 -0.01010 -0.00030 -0.02190 1612 ILE A CG1 
2418 C  CG2 . ILE A 153 ? 0.11510 0.09920 0.13990 -0.01840 -0.00650 -0.02040 1612 ILE A CG2 
2419 C  CD1 . ILE A 153 ? 0.13400 0.11380 0.17480 -0.00520 -0.01640 -0.03010 1612 ILE A CD1 
2431 N  N   . CYS A 154 ? 0.09950 0.08580 0.11300 0.00410  0.00660  0.00190  1613 CYS A N   
2432 C  CA  . CYS A 154 ? 0.09420 0.08820 0.11420 -0.00910 -0.00280 -0.01610 1613 CYS A CA  
2433 C  C   . CYS A 154 ? 0.09440 0.09320 0.11790 -0.00010 -0.01080 -0.00130 1613 CYS A C   
2434 O  O   . CYS A 154 ? 0.10690 0.08770 0.13560 0.01120  -0.00690 -0.01240 1613 CYS A O   
2435 C  CB  . CYS A 154 ? 0.09710 0.10190 0.15700 -0.00570 -0.00490 0.00850  1613 CYS A CB  
2436 S  SG  . CYS A 154 ? 0.10809 0.10529 0.17050 -0.00960 -0.01000 0.00940  1613 CYS A SG  
2441 N  N   . HIS A 155 ? 0.08570 0.10330 0.12810 0.00360  -0.02700 0.00180  1614 HIS A N   
2442 C  CA  . HIS A 155 ? 0.08770 0.10300 0.12000 0.00630  -0.01990 -0.02420 1614 HIS A CA  
2443 C  C   . HIS A 155 ? 0.09520 0.09860 0.14480 0.01590  0.00030  -0.00740 1614 HIS A C   
2444 O  O   . HIS A 155 ? 0.10400 0.08980 0.18150 0.01310  -0.00120 -0.00420 1614 HIS A O   
2445 C  CB  . HIS A 155 ? 0.09290 0.10310 0.11290 0.01760  -0.01460 -0.03800 1614 HIS A CB  
2446 C  CG  . HIS A 155 ? 0.10120 0.10300 0.12790 0.01510  -0.00920 -0.02390 1614 HIS A CG  
2447 N  ND1 . HIS A 155 ? 0.10380 0.11150 0.09490 0.01860  -0.00320 -0.00940 1614 HIS A ND1 
2448 C  CD2 . HIS A 155 ? 0.12080 0.10630 0.13640 -0.00170 -0.00710 -0.02750 1614 HIS A CD2 
2449 C  CE1 . HIS A 155 ? 0.10990 0.11080 0.15460 -0.00580 -0.03150 -0.00980 1614 HIS A CE1 
2450 N  NE2 . HIS A 155 ? 0.11840 0.11070 0.15910 -0.01280 -0.00200 -0.01400 1614 HIS A NE2 
2458 N  N   . VAL A 156 ? 0.09730 0.10550 0.14150 0.01390  -0.00690 0.00630  1615 VAL A N   
2459 C  CA  . VAL A 156 ? 0.11170 0.09930 0.11570 0.00680  0.00360  -0.00670 1615 VAL A CA  
2460 C  C   . VAL A 156 ? 0.10660 0.09610 0.11600 -0.00300 -0.00410 -0.00310 1615 VAL A C   
2461 O  O   . VAL A 156 ? 0.11830 0.11839 0.13780 0.00810  -0.00460 -0.00610 1615 VAL A O   
2462 C  CB  . VAL A 156 ? 0.09530 0.10890 0.14930 -0.00050 -0.01660 0.00170  1615 VAL A CB  
2463 C  CG1 . VAL A 156 ? 0.11100 0.12050 0.17740 -0.00430 0.01630  -0.00170 1615 VAL A CG1 
2464 C  CG2 . VAL A 156 ? 0.10650 0.11840 0.17100 0.00920  -0.01350 -0.00320 1615 VAL A CG2 
2474 N  N   . ALA A 157 ? 0.11250 0.09330 0.13360 -0.00520 -0.01050 0.00550  1616 ALA A N   
2475 C  CA  . ALA A 157 ? 0.09290 0.11210 0.17290 0.00230  -0.02350 -0.00170 1616 ALA A CA  
2476 C  C   . ALA A 157 ? 0.09770 0.11610 0.17450 0.01840  -0.01940 -0.00700 1616 ALA A C   
2477 O  O   . ALA A 157 ? 0.12230 0.11650 0.19280 0.01660  -0.02970 -0.00350 1616 ALA A O   
2478 C  CB  . ALA A 157 ? 0.10430 0.13239 0.23170 -0.00130 -0.00870 -0.00310 1616 ALA A CB  
2484 N  N   . ARG A 158 ? 0.10990 0.10540 0.16860 -0.00440 -0.01000 0.00840  1617 ARG A N   
2485 C  CA  . ARG A 158 ? 0.13920 0.09950 0.15230 0.00270  0.01190  0.02530  1617 ARG A CA  
2486 C  C   . ARG A 158 ? 0.12430 0.09730 0.14260 0.00060  -0.00710 0.01440  1617 ARG A C   
2487 O  O   . ARG A 158 ? 0.11730 0.09450 0.18310 0.00060  -0.00920 0.01430  1617 ARG A O   
2488 C  CB  . ARG A 158 ? 0.14550 0.10210 0.16090 0.01010  -0.00040 0.01760  1617 ARG A CB  
2489 C  CG  . ARG A 158 ? 0.16200 0.13110 0.21130 -0.01250 0.03050  0.00930  1617 ARG A CG  
2490 C  CD  . ARG A 158 ? 0.16210 0.15649 0.21230 0.00820  0.01020  0.00360  1617 ARG A CD  
2491 N  NE  . ARG A 158 ? 0.15430 0.16590 0.26070 0.02140  0.00590  0.00510  1617 ARG A NE  
2492 C  CZ  . ARG A 158 ? 0.14860 0.17970 0.24410 -0.00240 -0.01040 -0.00040 1617 ARG A CZ  
2493 N  NH1 . ARG A 158 ? 0.13740 0.18020 0.20440 -0.02730 -0.01090 0.02550  1617 ARG A NH1 
2494 N  NH2 . ARG A 158 ? 0.15640 0.19240 0.25770 -0.00810 -0.00270 -0.00090 1617 ARG A NH2 
2508 N  N   . LYS A 159 ? 0.11540 0.10660 0.16430 -0.00040 0.00180  0.02780  1618 LYS A N   
2509 C  CA  . LYS A 159 ? 0.13330 0.11000 0.17250 0.00760  0.01900  0.01240  1618 LYS A CA  
2510 C  C   . LYS A 159 ? 0.14960 0.10200 0.16050 -0.00690 0.01270  0.00030  1618 LYS A C   
2511 O  O   . LYS A 159 ? 0.12920 0.10930 0.19370 0.00410  -0.00740 0.01880  1618 LYS A O   
2512 C  CB  . LYS A 159 ? 0.13760 0.12030 0.19070 0.00340  -0.00130 0.00860  1618 LYS A CB  
2513 C  CG  . LYS A 159 ? 0.16540 0.12380 0.20650 -0.00470 0.00030  0.03140  1618 LYS A CG  
2514 C  CD  . LYS A 159 ? 0.21290 0.16370 0.27310 -0.01720 -0.02080 0.06450  1618 LYS A CD  
2515 C  CE  . LYS A 159 ? 0.30710 0.20929 0.33920 -0.01990 -0.03460 0.09380  1618 LYS A CE  
2516 N  NZ  . LYS A 159 ? 0.36479 0.23809 0.39670 -0.02710 -0.02790 0.11940  1618 LYS A NZ  
2530 N  N   . GLU A 160 ? 0.14440 0.10240 0.13470 -0.00140 0.02560  -0.01180 1619 GLU A N   
2531 C  CA  . GLU A 160 ? 0.15570 0.11270 0.15790 0.02170  0.00650  -0.02460 1619 GLU A CA  
2532 C  C   . GLU A 160 ? 0.14000 0.10980 0.18570 0.00480  -0.01830 -0.02080 1619 GLU A C   
2533 O  O   . GLU A 160 ? 0.14150 0.10160 0.19260 0.00210  -0.02710 -0.00830 1619 GLU A O   
2534 C  CB  . GLU A 160 ? 0.19980 0.13809 0.16840 0.04780  0.01900  -0.04390 1619 GLU A CB  
2535 C  CG  . GLU A 160 ? 0.22330 0.14770 0.18030 0.03080  0.03810  -0.03170 1619 GLU A CG  
2536 C  CD  . GLU A 160 ? 0.21920 0.15550 0.16930 0.00330  0.05810  -0.02340 1619 GLU A CD  
2537 O  OE1 . GLU A 160 ? 0.21230 0.16500 0.21550 0.00360  0.01180  -0.01750 1619 GLU A OE1 
2538 O  OE2 . GLU A 160 ? 0.23110 0.16360 0.19620 -0.00740 0.05640  -0.03030 1619 GLU A OE2 
2545 N  N   . GLU A 161 ? 0.11440 0.10720 0.16840 0.00020  -0.00120 -0.02040 1620 GLU A N   
2546 C  CA  . GLU A 161 ? 0.12460 0.10780 0.14610 0.00250  -0.01460 -0.00090 1620 GLU A CA  
2547 C  C   . GLU A 161 ? 0.11060 0.10660 0.10620 0.00500  -0.00710 0.01760  1620 GLU A C   
2548 O  O   . GLU A 161 ? 0.11230 0.10500 0.16230 0.01000  -0.01520 -0.00210 1620 GLU A O   
2549 C  CB  . GLU A 161 ? 0.13250 0.10810 0.16340 0.00740  0.01390  0.00270  1620 GLU A CB  
2550 C  CG  . GLU A 161 ? 0.11730 0.10710 0.19950 0.00510  0.01320  -0.00450 1620 GLU A CG  
2551 C  CD  . GLU A 161 ? 0.12980 0.11450 0.16360 -0.00010 -0.00800 -0.00550 1620 GLU A CD  
2552 O  OE1 . GLU A 161 ? 0.14660 0.11430 0.19060 -0.00370 0.00160  -0.01320 1620 GLU A OE1 
2553 O  OE2 . GLU A 161 ? 0.13550 0.14459 0.18070 -0.01920 0.01230  -0.01050 1620 GLU A OE2 
2560 N  N   . ILE A 162 ? 0.09970 0.11290 0.12910 0.00660  -0.00660 0.00320  1621 ILE A N   
2561 C  CA  . ILE A 162 ? 0.11430 0.11120 0.12080 0.00600  -0.00470 0.00940  1621 ILE A CA  
2562 C  C   . ILE A 162 ? 0.12110 0.10640 0.15230 -0.01190 0.01240  0.00430  1621 ILE A C   
2563 O  O   . ILE A 162 ? 0.11200 0.10720 0.18190 -0.01030 0.00970  -0.00450 1621 ILE A O   
2564 C  CB  . ILE A 162 ? 0.12140 0.12280 0.13000 0.00370  -0.00010 0.00230  1621 ILE A CB  
2565 C  CG1 . ILE A 162 ? 0.12710 0.12050 0.14910 0.00500  0.00670  -0.00050 1621 ILE A CG1 
2566 C  CG2 . ILE A 162 ? 0.13580 0.13600 0.15400 0.00660  0.00100  0.00600  1621 ILE A CG2 
2567 C  CD1 . ILE A 162 ? 0.13140 0.11280 0.18840 0.00660  0.03450  -0.01190 1621 ILE A CD1 
2579 N  N   . LEU A 163 ? 0.12000 0.10140 0.16320 -0.01210 0.00970  -0.00710 1622 LEU A N   
2580 C  CA  . LEU A 163 ? 0.13040 0.10840 0.16170 -0.00280 0.00670  0.00900  1622 LEU A CA  
2581 C  C   . LEU A 163 ? 0.14280 0.10560 0.13930 0.01650  0.00900  0.00480  1622 LEU A C   
2582 O  O   . LEU A 163 ? 0.12530 0.10490 0.20670 -0.00850 0.00700  -0.00160 1622 LEU A O   
2583 C  CB  . LEU A 163 ? 0.12920 0.11970 0.14320 -0.01470 0.01790  -0.01230 1622 LEU A CB  
2584 C  CG  . LEU A 163 ? 0.14170 0.12690 0.17120 -0.00910 0.03020  0.00320  1622 LEU A CG  
2585 C  CD1 . LEU A 163 ? 0.16620 0.13100 0.22070 0.01180  -0.00150 0.02060  1622 LEU A CD1 
2586 C  CD2 . LEU A 163 ? 0.16390 0.13750 0.20110 0.00160  0.02410  0.02170  1622 LEU A CD2 
2598 N  N   A LEU A 164 ? 0.13470 0.10980 0.13930 0.00660  -0.00450 -0.01070 1623 LEU A N   
2599 N  N   B LEU A 164 ? 0.13290 0.11260 0.13930 0.01040  -0.00640 -0.01300 1623 LEU A N   
2600 C  CA  A LEU A 164 ? 0.12480 0.11660 0.15360 0.00090  0.01530  -0.00390 1623 LEU A CA  
2601 C  CA  B LEU A 164 ? 0.12090 0.12440 0.15530 0.00850  0.01370  -0.00460 1623 LEU A CA  
2602 C  C   A LEU A 164 ? 0.10410 0.11430 0.17870 -0.00580 0.00670  -0.00410 1623 LEU A C   
2603 C  C   B LEU A 164 ? 0.10290 0.11840 0.18130 -0.00270 0.00450  -0.00630 1623 LEU A C   
2604 O  O   A LEU A 164 ? 0.10600 0.12050 0.17670 -0.00440 0.02050  -0.01050 1623 LEU A O   
2605 O  O   B LEU A 164 ? 0.10640 0.12590 0.17360 -0.00120 0.01350  -0.01490 1623 LEU A O   
2606 C  CB  A LEU A 164 ? 0.14630 0.11900 0.17000 -0.01530 0.00270  -0.01790 1623 LEU A CB  
2607 C  CB  B LEU A 164 ? 0.14350 0.13810 0.17350 0.00310  -0.00060 -0.01710 1623 LEU A CB  
2608 C  CG  A LEU A 164 ? 0.19200 0.13660 0.19430 -0.01590 0.01820  -0.02210 1623 LEU A CG  
2609 C  CG  B LEU A 164 ? 0.19450 0.16400 0.20610 -0.00570 0.00060  -0.01080 1623 LEU A CG  
2610 C  CD1 A LEU A 164 ? 0.20010 0.15759 0.22930 -0.00690 0.00570  -0.01910 1623 LEU A CD1 
2611 C  CD1 B LEU A 164 ? 0.21000 0.17030 0.21740 -0.01400 -0.02820 -0.01130 1623 LEU A CD1 
2612 C  CD2 A LEU A 164 ? 0.19970 0.13450 0.18670 -0.00860 0.01480  -0.05140 1623 LEU A CD2 
2613 C  CD2 B LEU A 164 ? 0.21920 0.17680 0.23430 -0.02700 0.02560  0.00290  1623 LEU A CD2 
2636 N  N   . ILE A 165 ? 0.09710 0.11130 0.19900 -0.00770 -0.00110 -0.00190 1624 ILE A N   
2637 C  CA  . ILE A 165 ? 0.11020 0.11880 0.14970 -0.00200 0.00030  0.00030  1624 ILE A CA  
2638 C  C   . ILE A 165 ? 0.10640 0.12020 0.16710 -0.02020 0.00820  -0.01430 1624 ILE A C   
2639 O  O   . ILE A 165 ? 0.09640 0.12050 0.18920 -0.01930 -0.00710 -0.00630 1624 ILE A O   
2640 C  CB  . ILE A 165 ? 0.12160 0.11500 0.10970 -0.00550 -0.00880 0.00000  1624 ILE A CB  
2641 C  CG1 . ILE A 165 ? 0.11990 0.12510 0.12760 0.00090  0.00210  0.01510  1624 ILE A CG1 
2642 C  CG2 . ILE A 165 ? 0.12140 0.11970 0.15700 0.00940  -0.00190 0.00700  1624 ILE A CG2 
2643 C  CD1 . ILE A 165 ? 0.10420 0.12000 0.18570 -0.01000 -0.00360 -0.00140 1624 ILE A CD1 
2655 N  N   . LYS A 166 ? 0.10730 0.12230 0.15110 -0.00880 0.01990  -0.01580 1625 LYS A N   
2656 C  CA  A LYS A 166 ? 0.11800 0.12550 0.15080 -0.00990 0.02860  -0.01130 1625 LYS A CA  
2657 C  CA  B LYS A 166 ? 0.11900 0.11940 0.15120 -0.00150 0.02150  -0.00610 1625 LYS A CA  
2658 C  C   . LYS A 166 ? 0.11270 0.11750 0.14440 -0.01840 0.02850  -0.00100 1625 LYS A C   
2659 O  O   . LYS A 166 ? 0.11090 0.12980 0.18930 -0.01590 0.02300  -0.01800 1625 LYS A O   
2660 C  CB  A LYS A 166 ? 0.14180 0.14460 0.15100 -0.01840 0.03750  -0.01110 1625 LYS A CB  
2661 C  CB  B LYS A 166 ? 0.16100 0.13380 0.14950 -0.01690 0.00410  0.01440  1625 LYS A CB  
2662 C  CG  A LYS A 166 ? 0.13970 0.16070 0.15500 -0.02060 0.05140  -0.00930 1625 LYS A CG  
2663 C  CG  B LYS A 166 ? 0.16810 0.14650 0.14130 -0.01500 -0.00790 0.01920  1625 LYS A CG  
2664 C  CD  A LYS A 166 ? 0.16310 0.17560 0.13960 -0.01620 0.05740  -0.01280 1625 LYS A CD  
2665 C  CD  B LYS A 166 ? 0.20600 0.16390 0.17590 -0.01500 -0.00630 0.02450  1625 LYS A CD  
2666 C  CE  A LYS A 166 ? 0.20180 0.18630 0.19020 -0.01400 0.00300  -0.01320 1625 LYS A CE  
2667 C  CE  B LYS A 166 ? 0.23040 0.16750 0.17910 -0.01350 -0.02250 0.02750  1625 LYS A CE  
2668 N  NZ  A LYS A 166 ? 0.21840 0.18850 0.24230 -0.01260 -0.01540 -0.01590 1625 LYS A NZ  
2669 N  NZ  B LYS A 166 ? 0.24240 0.17340 0.22050 -0.00400 -0.03350 0.02110  1625 LYS A NZ  
2696 N  N   . ALA A 167 ? 0.10950 0.11130 0.18600 -0.00830 0.00960  -0.01150 1626 ALA A N   
2697 C  CA  . ALA A 167 ? 0.11870 0.11220 0.19220 -0.00430 0.00880  -0.02770 1626 ALA A CA  
2698 C  C   . ALA A 167 ? 0.10850 0.10790 0.17960 -0.01270 0.01370  -0.02350 1626 ALA A C   
2699 O  O   . ALA A 167 ? 0.11850 0.10850 0.23110 -0.01990 0.02810  -0.02850 1626 ALA A O   
2700 C  CB  . ALA A 167 ? 0.13600 0.11320 0.19170 -0.00640 0.01810  -0.01700 1626 ALA A CB  
2706 N  N   . ALA A 168 ? 0.11920 0.12000 0.17010 -0.01480 -0.00780 -0.02080 1627 ALA A N   
2707 C  CA  . ALA A 168 ? 0.14190 0.12919 0.16540 -0.01670 -0.00650 -0.01220 1627 ALA A CA  
2708 C  C   . ALA A 168 ? 0.11980 0.13390 0.18020 -0.01590 0.00850  -0.01630 1627 ALA A C   
2709 O  O   . ALA A 168 ? 0.10500 0.13600 0.20000 -0.01020 -0.01440 -0.02500 1627 ALA A O   
2710 C  CB  . ALA A 168 ? 0.13460 0.11790 0.18170 0.00060  0.00170  -0.00100 1627 ALA A CB  
2716 N  N   . LYS A 169 ? 0.10400 0.13050 0.19200 -0.01410 -0.00500 -0.02830 1628 LYS A N   
2717 C  CA  . LYS A 169 ? 0.11520 0.12830 0.19990 -0.02220 0.01530  -0.02600 1628 LYS A CA  
2718 C  C   . LYS A 169 ? 0.12430 0.13810 0.21310 -0.03090 0.01350  -0.03510 1628 LYS A C   
2719 O  O   . LYS A 169 ? 0.11970 0.15240 0.27160 -0.01330 0.02240  -0.05890 1628 LYS A O   
2720 C  CB  . LYS A 169 ? 0.11940 0.12530 0.20750 -0.00800 0.00440  -0.01100 1628 LYS A CB  
2721 C  CG  . LYS A 169 ? 0.11190 0.12340 0.17570 -0.00810 0.00230  -0.03320 1628 LYS A CG  
2722 C  CD  . LYS A 169 ? 0.13070 0.12700 0.19770 0.00070  0.02060  -0.02610 1628 LYS A CD  
2723 C  CE  . LYS A 169 ? 0.11130 0.12530 0.17050 -0.01840 0.01650  -0.01020 1628 LYS A CE  
2724 N  NZ  . LYS A 169 ? 0.12510 0.12050 0.16680 -0.01990 0.00770  -0.02460 1628 LYS A NZ  
2738 N  N   . ALA A 170 ? 0.12940 0.13690 0.20390 -0.03600 0.02100  -0.03210 1629 ALA A N   
2739 C  CA  . ALA A 170 ? 0.13410 0.15340 0.20740 -0.03530 0.03530  -0.03540 1629 ALA A CA  
2740 C  C   . ALA A 170 ? 0.13360 0.17220 0.22530 -0.03950 0.02620  -0.02980 1629 ALA A C   
2741 O  O   . ALA A 170 ? 0.13130 0.22299 0.28080 -0.05980 0.03110  -0.02450 1629 ALA A O   
2742 C  CB  . ALA A 170 ? 0.16290 0.15580 0.24860 -0.02450 0.01920  -0.01530 1629 ALA A CB  
2748 N  N   A ARG A 171 ? 0.14260 0.17070 0.21430 -0.03690 0.00680  -0.02340 1630 ARG A N   
2749 N  N   B ARG A 171 ? 0.11590 0.14710 0.21660 -0.04100 0.00240  -0.02260 1630 ARG A N   
2750 C  CA  A ARG A 171 ? 0.16160 0.18170 0.20140 -0.03380 -0.00190 -0.01520 1630 ARG A CA  
2751 C  CA  B ARG A 171 ? 0.14190 0.15700 0.18750 -0.04100 -0.00500 -0.01130 1630 ARG A CA  
2752 C  C   A ARG A 171 ? 0.15030 0.17880 0.21560 -0.04410 -0.00220 -0.01700 1630 ARG A C   
2753 C  C   B ARG A 171 ? 0.13630 0.16750 0.22150 -0.05600 -0.00420 -0.02540 1630 ARG A C   
2754 O  O   A ARG A 171 ? 0.16720 0.18470 0.22250 -0.04410 -0.00580 -0.02500 1630 ARG A O   
2755 O  O   B ARG A 171 ? 0.17710 0.17820 0.24450 -0.04450 0.02000  -0.03300 1630 ARG A O   
2756 C  CB  A ARG A 171 ? 0.19390 0.19740 0.21070 -0.02360 0.00080  -0.01540 1630 ARG A CB  
2757 C  CB  B ARG A 171 ? 0.17960 0.16430 0.18710 -0.03160 0.00040  -0.01180 1630 ARG A CB  
2758 C  CG  A ARG A 171 ? 0.22020 0.21940 0.23500 -0.01310 0.00440  -0.01640 1630 ARG A CG  
2759 C  CG  B ARG A 171 ? 0.19450 0.19160 0.23330 -0.02520 -0.00340 -0.01860 1630 ARG A CG  
2760 C  CD  A ARG A 171 ? 0.25620 0.24280 0.27600 -0.00200 0.00440  -0.01600 1630 ARG A CD  
2761 C  CD  B ARG A 171 ? 0.23710 0.22940 0.29000 -0.00780 -0.01120 -0.02000 1630 ARG A CD  
2762 N  NE  A ARG A 171 ? 0.28640 0.26200 0.29640 0.00240  0.00130  -0.03200 1630 ARG A NE  
2763 N  NE  B ARG A 171 ? 0.26600 0.25830 0.31310 -0.01000 -0.03220 -0.04790 1630 ARG A NE  
2764 C  CZ  A ARG A 171 ? 0.29720 0.27360 0.32140 0.01850  -0.01440 -0.03970 1630 ARG A CZ  
2765 C  CZ  B ARG A 171 ? 0.33420 0.27850 0.35630 -0.01940 -0.03320 -0.06170 1630 ARG A CZ  
2766 N  NH1 A ARG A 171 ? 0.26990 0.27350 0.29910 0.03140  0.00930  -0.05180 1630 ARG A NH1 
2767 N  NH1 B ARG A 171 ? 0.30520 0.28420 0.38610 -0.03630 0.00200  -0.05160 1630 ARG A NH1 
2768 N  NH2 A ARG A 171 ? 0.32610 0.27880 0.33600 0.03200  -0.04960 -0.04150 1630 ARG A NH2 
2769 N  NH2 B ARG A 171 ? 0.39060 0.28770 0.36890 -0.00130 -0.06270 -0.07160 1630 ARG A NH2 
2796 N  N   . GLY A 172 ? 0.12580 0.16920 0.23750 -0.04200 0.00020  -0.00410 1631 GLY A N   
2797 C  CA  . GLY A 172 ? 0.14060 0.16110 0.24960 -0.02770 0.00430  -0.01010 1631 GLY A CA  
2798 C  C   . GLY A 172 ? 0.13210 0.15610 0.26340 -0.00330 -0.00710 -0.01210 1631 GLY A C   
2799 O  O   . GLY A 172 ? 0.13850 0.16500 0.28020 0.00110  -0.02400 0.00160  1631 GLY A O   
2803 N  N   . LEU A 173 ? 0.11780 0.13900 0.21200 -0.01090 0.00770  -0.02190 1632 LEU A N   
2804 C  CA  . LEU A 173 ? 0.12150 0.13090 0.18980 0.00260  0.00620  -0.01950 1632 LEU A CA  
2805 C  C   . LEU A 173 ? 0.11450 0.12950 0.17380 -0.00430 0.00580  -0.02500 1632 LEU A C   
2806 O  O   . LEU A 173 ? 0.11370 0.12900 0.19350 -0.01810 0.00680  -0.01750 1632 LEU A O   
2807 C  CB  . LEU A 173 ? 0.15530 0.12770 0.20380 0.00300  0.02780  -0.00330 1632 LEU A CB  
2808 C  CG  . LEU A 173 ? 0.20800 0.14320 0.23060 0.00750  -0.01180 -0.02040 1632 LEU A CG  
2809 C  CD1 . LEU A 173 ? 0.23210 0.14450 0.24650 0.03030  0.01430  -0.03420 1632 LEU A CD1 
2810 C  CD2 . LEU A 173 ? 0.24530 0.15220 0.26840 0.00240  -0.06270 -0.02630 1632 LEU A CD2 
2822 N  N   . PRO A 174 ? 0.10140 0.13140 0.17200 -0.00650 -0.00250 -0.02070 1633 PRO A N   
2823 C  CA  . PRO A 174 ? 0.10670 0.12700 0.16330 -0.00880 -0.02170 -0.01290 1633 PRO A CA  
2824 C  C   . PRO A 174 ? 0.11430 0.11580 0.12840 -0.01090 -0.01500 0.00980  1633 PRO A C   
2825 O  O   . PRO A 174 ? 0.11040 0.12920 0.17070 -0.00560 -0.01710 0.00570  1633 PRO A O   
2826 C  CB  . PRO A 174 ? 0.10410 0.15289 0.16980 -0.00220 -0.01550 -0.01270 1633 PRO A CB  
2827 C  CG  . PRO A 174 ? 0.11210 0.15160 0.14100 -0.00240 -0.01790 -0.00800 1633 PRO A CG  
2828 C  CD  . PRO A 174 ? 0.13879 0.14380 0.16940 -0.00740 -0.00070 -0.01040 1633 PRO A CD  
2836 N  N   . VAL A 175 ? 0.08840 0.11370 0.15550 -0.01030 -0.00120 0.00640  1634 VAL A N   
2837 C  CA  . VAL A 175 ? 0.09550 0.11650 0.15740 -0.00920 0.00930  -0.00400 1634 VAL A CA  
2838 C  C   . VAL A 175 ? 0.10800 0.11700 0.12100 -0.00660 0.01000  -0.00530 1634 VAL A C   
2839 O  O   . VAL A 175 ? 0.10560 0.13020 0.15360 -0.01620 -0.00230 0.00100  1634 VAL A O   
2840 C  CB  . VAL A 175 ? 0.11750 0.11210 0.17880 -0.00190 -0.00930 -0.00180 1634 VAL A CB  
2841 C  CG1 . VAL A 175 ? 0.12920 0.12180 0.24350 -0.00320 0.01290  0.01250  1634 VAL A CG1 
2842 C  CG2 . VAL A 175 ? 0.12020 0.12290 0.19100 0.00290  -0.00960 -0.01150 1634 VAL A CG2 
2852 N  N   . THR A 176 ? 0.08760 0.10410 0.17260 -0.01820 -0.00670 0.00150  1635 THR A N   
2853 C  CA  . THR A 176 ? 0.08730 0.09500 0.16350 -0.01170 0.00320  0.00190  1635 THR A CA  
2854 C  C   . THR A 176 ? 0.10820 0.09610 0.12940 -0.01540 0.01030  -0.01660 1635 THR A C   
2855 O  O   . THR A 176 ? 0.10510 0.10290 0.13270 -0.01460 0.00210  -0.02010 1635 THR A O   
2856 C  CB  . THR A 176 ? 0.09700 0.09870 0.16420 -0.00380 -0.00170 -0.00260 1635 THR A CB  
2857 O  OG1 . THR A 176 ? 0.12850 0.10050 0.18840 0.00040  -0.01280 -0.01090 1635 THR A OG1 
2858 C  CG2 . THR A 176 ? 0.09840 0.11130 0.15930 0.00580  -0.00220 -0.01600 1635 THR A CG2 
2866 N  N   . CYS A 177 ? 0.09630 0.09390 0.15820 -0.00560 0.00520  -0.00800 1636 CYS A N   
2867 C  CA  . CYS A 177 ? 0.09300 0.09660 0.13240 0.00000  -0.00640 -0.00650 1636 CYS A CA  
2868 C  C   . CYS A 177 ? 0.09440 0.09850 0.11890 0.00100  0.01460  0.00310  1636 CYS A C   
2869 O  O   . CYS A 177 ? 0.09140 0.10770 0.13030 -0.00320 0.00960  -0.00810 1636 CYS A O   
2870 C  CB  . CYS A 177 ? 0.10260 0.10340 0.15720 0.00240  -0.00350 0.00180  1636 CYS A CB  
2871 S  SG  . CYS A 177 ? 0.14129 0.10080 0.15860 -0.00280 0.00940  -0.00580 1636 CYS A SG  
2877 N  N   . GLU A 178 ? 0.09830 0.10609 0.10900 -0.00000 -0.00100 -0.00160 1637 GLU A N   
2878 C  CA  . GLU A 178 ? 0.08110 0.09640 0.12850 -0.00170 -0.00700 0.00470  1637 GLU A CA  
2879 C  C   . GLU A 178 ? 0.09280 0.09270 0.12750 -0.00700 0.02060  -0.00150 1637 GLU A C   
2880 O  O   . GLU A 178 ? 0.09030 0.10160 0.16190 0.00120  0.00340  -0.00030 1637 GLU A O   
2881 C  CB  . GLU A 178 ? 0.12409 0.09620 0.13510 -0.00260 -0.01790 0.00550  1637 GLU A CB  
2882 C  CG  . GLU A 178 ? 0.10720 0.09660 0.13320 -0.00470 0.00650  0.00080  1637 GLU A CG  
2883 C  CD  . GLU A 178 ? 0.11830 0.09310 0.14010 -0.01050 0.01480  -0.02440 1637 GLU A CD  
2884 O  OE1 . GLU A 178 ? 0.13140 0.09060 0.14640 -0.01730 0.00660  -0.00040 1637 GLU A OE1 
2885 O  OE2 . GLU A 178 ? 0.11780 0.09900 0.18390 -0.01310 0.03050  -0.00230 1637 GLU A OE2 
2892 N  N   . VAL A 179 ? 0.10980 0.08830 0.11590 0.01120  0.00740  -0.00100 1638 VAL A N   
2893 C  CA  . VAL A 179 ? 0.10870 0.09410 0.14380 0.01460  -0.00010 0.00420  1638 VAL A CA  
2894 C  C   . VAL A 179 ? 0.09660 0.10180 0.16210 0.00720  -0.01590 -0.00050 1638 VAL A C   
2895 O  O   . VAL A 179 ? 0.08780 0.09760 0.16530 0.01090  0.00300  -0.01280 1638 VAL A O   
2896 C  CB  . VAL A 179 ? 0.09010 0.11360 0.15300 -0.01010 -0.01590 0.01080  1638 VAL A CB  
2897 C  CG1 . VAL A 179 ? 0.10620 0.11020 0.17160 0.00110  -0.00690 0.00380  1638 VAL A CG1 
2898 C  CG2 . VAL A 179 ? 0.10050 0.12170 0.14060 0.00130  0.00800  -0.00180 1638 VAL A CG2 
2908 N  N   . ALA A 180 ? 0.08990 0.10930 0.15850 0.00770  -0.01300 -0.00950 1639 ALA A N   
2909 C  CA  . ALA A 180 ? 0.08620 0.11889 0.14140 0.00980  -0.00570 -0.02020 1639 ALA A CA  
2910 C  C   . ALA A 180 ? 0.09090 0.11870 0.14420 0.01120  -0.00880 -0.00330 1639 ALA A C   
2911 O  O   . ALA A 180 ? 0.09330 0.11710 0.17900 0.00760  -0.00520 0.00660  1639 ALA A O   
2912 C  CB  . ALA A 180 ? 0.09240 0.11160 0.18140 0.00850  0.00240  -0.01930 1639 ALA A CB  
2918 N  N   . PRO A 181 ? 0.11050 0.11430 0.14950 0.00130  -0.00720 -0.02160 1640 PRO A N   
2919 C  CA  . PRO A 181 ? 0.12770 0.12120 0.13990 0.01520  -0.01320 -0.03060 1640 PRO A CA  
2920 C  C   . PRO A 181 ? 0.11340 0.12410 0.13620 0.00290  -0.00540 -0.00760 1640 PRO A C   
2921 O  O   . PRO A 181 ? 0.12770 0.14089 0.12740 -0.00050 -0.00630 -0.00700 1640 PRO A O   
2922 C  CB  . PRO A 181 ? 0.16240 0.12310 0.18870 0.00990  -0.00740 -0.03530 1640 PRO A CB  
2923 C  CG  . PRO A 181 ? 0.19099 0.12689 0.24719 -0.00050 -0.05920 -0.02150 1640 PRO A CG  
2924 C  CD  . PRO A 181 ? 0.13140 0.11110 0.19820 -0.00510 -0.01870 -0.01270 1640 PRO A CD  
2932 N  N   . HIS A 182 ? 0.09880 0.11910 0.14350 0.01120  -0.01800 -0.00870 1641 HIS A N   
2933 C  CA  . HIS A 182 ? 0.11870 0.12430 0.14030 0.01240  0.00440  0.00330  1641 HIS A CA  
2934 C  C   . HIS A 182 ? 0.11060 0.13469 0.14920 0.00740  0.00220  0.00490  1641 HIS A C   
2935 O  O   . HIS A 182 ? 0.11950 0.13340 0.18500 0.00780  -0.03000 0.00620  1641 HIS A O   
2936 C  CB  . HIS A 182 ? 0.11750 0.12960 0.14900 0.01990  -0.00950 0.00080  1641 HIS A CB  
2937 C  CG  . HIS A 182 ? 0.10490 0.13130 0.14490 0.00340  0.00780  0.01580  1641 HIS A CG  
2938 N  ND1 . HIS A 182 ? 0.09720 0.12210 0.16000 0.00140  0.00050  0.02030  1641 HIS A ND1 
2939 C  CD2 . HIS A 182 ? 0.08960 0.12960 0.15190 0.00030  -0.00740 0.02050  1641 HIS A CD2 
2940 C  CE1 . HIS A 182 ? 0.10020 0.12160 0.13970 0.01110  0.01730  0.01160  1641 HIS A CE1 
2941 N  NE2 . HIS A 182 ? 0.09190 0.12250 0.14930 0.01380  0.00620  0.00360  1641 HIS A NE2 
2949 N  N   . HIS A 183 ? 0.09890 0.11890 0.15970 0.00700  -0.02580 -0.00650 1642 HIS A N   
2950 C  CA  . HIS A 183 ? 0.12550 0.12200 0.08780 0.01030  -0.01000 -0.00080 1642 HIS A CA  
2951 C  C   . HIS A 183 ? 0.12020 0.12369 0.08720 0.01700  -0.01620 0.00580  1642 HIS A C   
2952 O  O   . HIS A 183 ? 0.13660 0.11620 0.17490 0.01240  0.00500  -0.00030 1642 HIS A O   
2953 C  CB  . HIS A 183 ? 0.12630 0.12790 0.07620 0.01670  -0.00230 0.01470  1642 HIS A CB  
2954 C  CG  . HIS A 183 ? 0.11560 0.13020 0.04950 -0.00330 -0.00390 0.00720  1642 HIS A CG  
2955 N  ND1 . HIS A 183 ? 0.10540 0.12840 0.10860 0.00070  0.00410  0.00110  1642 HIS A ND1 
2956 C  CD2 . HIS A 183 ? 0.10920 0.13510 0.13650 0.02170  -0.00720 -0.01810 1642 HIS A CD2 
2957 C  CE1 . HIS A 183 ? 0.09810 0.12790 0.15640 0.01010  -0.01370 -0.02130 1642 HIS A CE1 
2958 N  NE2 . HIS A 183 ? 0.10850 0.13400 0.15210 0.01130  -0.00870 -0.01300 1642 HIS A NE2 
2966 N  N   . LEU A 184 ? 0.11890 0.11580 0.14230 0.01240  -0.00760 -0.01030 1643 LEU A N   
2967 C  CA  . LEU A 184 ? 0.10540 0.13530 0.15070 0.01420  0.00980  -0.01340 1643 LEU A CA  
2968 C  C   . LEU A 184 ? 0.11480 0.14950 0.13260 0.01240  0.00120  0.00550  1643 LEU A C   
2969 O  O   . LEU A 184 ? 0.13490 0.16120 0.14840 -0.01170 0.00350  0.00490  1643 LEU A O   
2970 C  CB  . LEU A 184 ? 0.10980 0.14150 0.15720 0.00390  -0.00410 -0.00420 1643 LEU A CB  
2971 C  CG  . LEU A 184 ? 0.10920 0.15540 0.16510 0.01410  0.00060  0.00050  1643 LEU A CG  
2972 C  CD1 . LEU A 184 ? 0.14610 0.16570 0.21110 0.03310  -0.01150 -0.00180 1643 LEU A CD1 
2973 C  CD2 . LEU A 184 ? 0.13790 0.16010 0.18070 -0.00690 0.00310  0.00350  1643 LEU A CD2 
2985 N  N   . PHE A 185 ? 0.12520 0.15650 0.16230 0.00970  -0.00160 -0.01140 1644 PHE A N   
2986 C  CA  . PHE A 185 ? 0.11790 0.16740 0.15320 0.01630  -0.01970 -0.00190 1644 PHE A CA  
2987 C  C   . PHE A 185 ? 0.14080 0.17780 0.10060 0.00420  -0.02360 -0.01500 1644 PHE A C   
2988 O  O   . PHE A 185 ? 0.15090 0.20369 0.17220 0.01050  -0.03440 -0.01500 1644 PHE A O   
2989 C  CB  . PHE A 185 ? 0.13310 0.17240 0.16560 0.00140  0.00180  -0.00320 1644 PHE A CB  
2990 C  CG  . PHE A 185 ? 0.14620 0.17180 0.14390 -0.00650 -0.01040 -0.00320 1644 PHE A CG  
2991 C  CD1 . PHE A 185 ? 0.17660 0.19599 0.16090 0.01980  0.00020  0.00990  1644 PHE A CD1 
2992 C  CD2 . PHE A 185 ? 0.12850 0.15700 0.17810 -0.00270 -0.01780 -0.00890 1644 PHE A CD2 
2993 C  CE1 . PHE A 185 ? 0.18240 0.19729 0.17560 0.01080  0.02050  0.01570  1644 PHE A CE1 
2994 C  CE2 . PHE A 185 ? 0.13170 0.15760 0.17740 -0.00900 -0.02010 -0.01900 1644 PHE A CE2 
2995 C  CZ  . PHE A 185 ? 0.14090 0.17000 0.18210 -0.00790 -0.00420 -0.01120 1644 PHE A CZ  
3005 N  N   . LEU A 186 ? 0.11470 0.17150 0.14630 0.01110  -0.03650 -0.00760 1645 LEU A N   
3006 C  CA  . LEU A 186 ? 0.10450 0.17330 0.17170 0.01960  -0.01120 0.00780  1645 LEU A CA  
3007 C  C   . LEU A 186 ? 0.10970 0.17120 0.17920 0.02210  -0.00970 0.01410  1645 LEU A C   
3008 O  O   . LEU A 186 ? 0.11510 0.16010 0.19460 0.02380  -0.01870 0.01460  1645 LEU A O   
3009 C  CB  . LEU A 186 ? 0.11410 0.17770 0.17000 0.01080  -0.00680 -0.01360 1645 LEU A CB  
3010 C  CG  . LEU A 186 ? 0.12640 0.17130 0.17370 0.02050  -0.02620 -0.01670 1645 LEU A CG  
3011 C  CD1 . LEU A 186 ? 0.13540 0.17250 0.18820 0.00440  -0.01580 0.00760  1645 LEU A CD1 
3012 C  CD2 . LEU A 186 ? 0.16550 0.17410 0.18820 0.02040  -0.03300 -0.01040 1645 LEU A CD2 
3024 N  N   . SER A 187 ? 0.13380 0.17340 0.17390 0.01850  -0.01990 0.00680  1646 SER A N   
3025 C  CA  . SER A 187 ? 0.13340 0.18280 0.17980 0.01460  -0.02050 -0.00590 1646 SER A CA  
3026 C  C   . SER A 187 ? 0.11930 0.18490 0.19140 0.01900  -0.01810 0.00190  1646 SER A C   
3027 O  O   . SER A 187 ? 0.11890 0.18720 0.21730 0.02460  -0.03160 -0.00540 1646 SER A O   
3028 C  CB  . SER A 187 ? 0.14520 0.19580 0.16640 0.01590  -0.02200 0.00010  1646 SER A CB  
3029 O  OG  . SER A 187 ? 0.16510 0.20120 0.20250 0.00670  -0.02670 0.00240  1646 SER A OG  
3035 N  N   . HIS A 188 ? 0.13570 0.18120 0.23400 0.02800  -0.01830 -0.02270 1647 HIS A N   
3036 C  CA  . HIS A 188 ? 0.16780 0.18660 0.25420 0.04460  -0.02350 -0.01600 1647 HIS A CA  
3037 C  C   . HIS A 188 ? 0.16380 0.19130 0.27970 0.03040  -0.03740 0.00390  1647 HIS A C   
3038 O  O   . HIS A 188 ? 0.14790 0.20500 0.30670 0.04120  -0.05140 0.00400  1647 HIS A O   
3039 C  CB  . HIS A 188 ? 0.18020 0.19480 0.23510 0.04930  -0.00130 -0.02050 1647 HIS A CB  
3040 C  CG  . HIS A 188 ? 0.18460 0.20530 0.23140 0.05220  -0.01620 -0.03530 1647 HIS A CG  
3041 N  ND1 . HIS A 188 ? 0.19500 0.21020 0.27290 0.04630  -0.01000 -0.03250 1647 HIS A ND1 
3042 C  CD2 . HIS A 188 ? 0.21140 0.21050 0.23030 0.05760  -0.00380 -0.03340 1647 HIS A CD2 
3043 C  CE1 . HIS A 188 ? 0.19740 0.21500 0.27550 0.03320  -0.01440 -0.04050 1647 HIS A CE1 
3044 N  NE2 . HIS A 188 ? 0.18470 0.21260 0.26120 0.04940  -0.00670 -0.04330 1647 HIS A NE2 
3052 N  N   . ASP A 189 ? 0.16870 0.20350 0.27330 0.02190  -0.05790 0.02620  1648 ASP A N   
3053 C  CA  . ASP A 189 ? 0.20430 0.23440 0.27080 0.02250  -0.06690 0.03610  1648 ASP A CA  
3054 C  C   . ASP A 189 ? 0.16970 0.22900 0.25630 0.03220  -0.07410 0.02590  1648 ASP A C   
3055 O  O   . ASP A 189 ? 0.20680 0.23680 0.28610 0.03170  -0.10440 0.02480  1648 ASP A O   
3056 C  CB  . ASP A 189 ? 0.28300 0.27680 0.27130 0.01900  -0.03810 0.03880  1648 ASP A CB  
3057 C  CG  . ASP A 189 ? 0.35670 0.31640 0.32930 0.01270  -0.00380 0.05540  1648 ASP A CG  
3058 O  OD1 . ASP A 189 ? 0.41020 0.31390 0.38990 0.00860  0.00280  0.06550  1648 ASP A OD1 
3059 O  OD2 . ASP A 189 ? 0.41629 0.34739 0.38480 0.00960  -0.04230 0.08190  1648 ASP A OD2 
3064 N  N   . ASP A 190 ? 0.16030 0.21460 0.23100 0.03080  -0.04920 0.02300  1649 ASP A N   
3065 C  CA  . ASP A 190 ? 0.16540 0.20280 0.20410 0.04140  -0.04070 0.00500  1649 ASP A CA  
3066 C  C   . ASP A 190 ? 0.13580 0.18860 0.20090 0.03480  -0.04180 -0.00460 1649 ASP A C   
3067 O  O   . ASP A 190 ? 0.14520 0.19430 0.22830 0.00760  -0.05470 0.01320  1649 ASP A O   
3068 C  CB  . ASP A 190 ? 0.16650 0.22110 0.18920 0.04480  -0.05150 -0.04230 1649 ASP A CB  
3069 C  CG  . ASP A 190 ? 0.16110 0.26410 0.22300 0.04380  -0.07340 -0.03820 1649 ASP A CG  
3070 O  OD1 . ASP A 190 ? 0.19810 0.32369 0.28800 0.03870  -0.06500 -0.05140 1649 ASP A OD1 
3071 O  OD2 . ASP A 190 ? 0.14580 0.23260 0.21310 0.04340  -0.04910 -0.03150 1649 ASP A OD2 
3076 N  N   . LEU A 191 ? 0.14190 0.18370 0.20290 0.03420  -0.03170 -0.01030 1650 LEU A N   
3077 C  CA  . LEU A 191 ? 0.15010 0.19920 0.20680 0.03830  -0.01000 -0.03820 1650 LEU A CA  
3078 C  C   . LEU A 191 ? 0.14200 0.22000 0.23670 0.02900  -0.02350 -0.02170 1650 LEU A C   
3079 O  O   . LEU A 191 ? 0.16440 0.22410 0.22990 0.01630  -0.00600 -0.02020 1650 LEU A O   
3080 C  CB  . LEU A 191 ? 0.17930 0.20670 0.22280 0.04060  -0.02680 -0.03930 1650 LEU A CB  
3081 C  CG  . LEU A 191 ? 0.20700 0.22850 0.24860 0.04020  -0.02360 -0.02250 1650 LEU A CG  
3082 C  CD1 . LEU A 191 ? 0.22690 0.23960 0.26400 0.03840  -0.04110 -0.04810 1650 LEU A CD1 
3083 C  CD2 . LEU A 191 ? 0.23300 0.24010 0.23790 0.04320  -0.02180 0.01010  1650 LEU A CD2 
3095 N  N   . GLU A 192 ? 0.12560 0.24280 0.29390 0.01940  -0.03270 -0.01090 1651 GLU A N   
3096 C  CA  . GLU A 192 ? 0.16390 0.26750 0.29640 0.01610  -0.04680 -0.00360 1651 GLU A CA  
3097 C  C   . GLU A 192 ? 0.14570 0.26830 0.27120 0.01680  -0.05180 -0.00710 1651 GLU A C   
3098 O  O   . GLU A 192 ? 0.14850 0.27880 0.27330 0.01630  -0.04680 -0.02680 1651 GLU A O   
3099 C  CB  . GLU A 192 ? 0.20650 0.30060 0.34730 0.03110  -0.08000 0.02810  1651 GLU A CB  
3100 C  CG  . GLU A 192 ? 0.30230 0.33810 0.40740 0.02160  -0.07830 0.06770  1651 GLU A CG  
3101 C  CD  . GLU A 192 ? 0.39530 0.38590 0.49270 0.01310  -0.08000 0.07810  1651 GLU A CD  
3102 O  OE1 . GLU A 192 ? 0.43720 0.40679 0.53650 0.02520  -0.07700 0.06830  1651 GLU A OE1 
3103 O  OE2 . GLU A 192 ? 0.43860 0.40419 0.51280 0.00380  -0.07870 0.07850  1651 GLU A OE2 
3110 N  N   . ARG A 193 ? 0.16340 0.26210 0.23200 0.03470  -0.05120 -0.01510 1652 ARG A N   
3111 C  CA  . ARG A 193 ? 0.17570 0.25250 0.23700 0.04460  -0.06430 -0.01130 1652 ARG A CA  
3112 C  C   . ARG A 193 ? 0.16460 0.22350 0.21510 0.03640  -0.04330 -0.00090 1652 ARG A C   
3113 O  O   . ARG A 193 ? 0.17980 0.21900 0.24170 0.02320  -0.05010 0.01820  1652 ARG A O   
3114 C  CB  . ARG A 193 ? 0.19850 0.25970 0.26510 0.04290  -0.05090 -0.03010 1652 ARG A CB  
3115 C  CG  . ARG A 193 ? 0.19320 0.26480 0.27890 0.02960  -0.02780 -0.05170 1652 ARG A CG  
3116 C  CD  . ARG A 193 ? 0.22110 0.26400 0.25250 0.03480  -0.06190 -0.04340 1652 ARG A CD  
3117 N  NE  . ARG A 193 ? 0.21530 0.26150 0.25440 0.03870  -0.07420 -0.01350 1652 ARG A NE  
3118 C  CZ  . ARG A 193 ? 0.22580 0.26080 0.26490 0.02480  -0.06340 0.01310  1652 ARG A CZ  
3119 N  NH1 . ARG A 193 ? 0.26030 0.25710 0.28750 0.00560  -0.06090 0.03870  1652 ARG A NH1 
3120 N  NH2 . ARG A 193 ? 0.21080 0.25980 0.25910 0.02380  -0.06930 0.00180  1652 ARG A NH2 
3134 N  N   . LEU A 194 ? 0.17450 0.20510 0.21510 0.03810  -0.03980 0.00110  1653 LEU A N   
3135 C  CA  . LEU A 194 ? 0.15990 0.20310 0.25450 0.03380  -0.02740 0.00550  1653 LEU A CA  
3136 C  C   . LEU A 194 ? 0.14870 0.21410 0.25840 0.01280  -0.05920 0.02210  1653 LEU A C   
3137 O  O   . LEU A 194 ? 0.15260 0.21580 0.29140 -0.00870 -0.04860 0.02290  1653 LEU A O   
3138 C  CB  . LEU A 194 ? 0.15070 0.19420 0.24650 0.02260  -0.03930 -0.00040 1653 LEU A CB  
3139 C  CG  . LEU A 194 ? 0.15280 0.19960 0.26450 0.03230  -0.04100 0.00460  1653 LEU A CG  
3140 C  CD1 . LEU A 194 ? 0.14130 0.21529 0.27730 0.02980  -0.02040 -0.00330 1653 LEU A CD1 
3141 C  CD2 . LEU A 194 ? 0.18910 0.19200 0.23130 0.03080  -0.02300 0.03290  1653 LEU A CD2 
3153 N  N   . GLY A 195 ? 0.14740 0.21660 0.24500 0.01310  -0.04830 0.02650  1654 GLY A N   
3154 C  CA  . GLY A 195 ? 0.15320 0.21010 0.24990 0.00210  -0.02900 -0.00060 1654 GLY A CA  
3155 C  C   . GLY A 195 ? 0.15190 0.19900 0.23500 0.00990  -0.01930 -0.01100 1654 GLY A C   
3156 O  O   . GLY A 195 ? 0.13810 0.20420 0.26910 0.00710  -0.03710 -0.01050 1654 GLY A O   
3160 N  N   . PRO A 196 ? 0.14330 0.20060 0.23660 0.01710  -0.03520 -0.00770 1655 PRO A N   
3161 C  CA  . PRO A 196 ? 0.17820 0.19470 0.24020 0.01280  -0.03060 -0.01030 1655 PRO A CA  
3162 C  C   . PRO A 196 ? 0.17670 0.19780 0.21910 0.00170  -0.04930 0.00150  1655 PRO A C   
3163 O  O   . PRO A 196 ? 0.23250 0.21210 0.28210 -0.01800 -0.06870 -0.00740 1655 PRO A O   
3164 C  CB  . PRO A 196 ? 0.20450 0.20520 0.27220 0.03400  -0.00270 -0.01950 1655 PRO A CB  
3165 C  CG  . PRO A 196 ? 0.19370 0.22419 0.28060 0.05240  -0.01100 -0.03740 1655 PRO A CG  
3166 C  CD  . PRO A 196 ? 0.15490 0.21910 0.25130 0.03350  -0.04620 -0.01780 1655 PRO A CD  
3174 N  N   . GLY A 197 ? 0.14510 0.19050 0.20150 0.00910  -0.01160 -0.00050 1656 GLY A N   
3175 C  CA  . GLY A 197 ? 0.14270 0.20029 0.24040 0.01660  -0.01110 0.02840  1656 GLY A CA  
3176 C  C   . GLY A 197 ? 0.12160 0.18360 0.21640 -0.00040 -0.00390 0.00890  1656 GLY A C   
3177 O  O   . GLY A 197 ? 0.10790 0.16080 0.24990 0.00540  -0.02690 0.00360  1656 GLY A O   
3181 N  N   . LYS A 198 ? 0.10010 0.19260 0.23920 0.00770  -0.02520 -0.00460 1657 LYS A N   
3182 C  CA  . LYS A 198 ? 0.12100 0.19870 0.20700 0.00600  -0.02340 0.01060  1657 LYS A CA  
3183 C  C   . LYS A 198 ? 0.10720 0.18510 0.22230 0.01540  -0.00460 0.01260  1657 LYS A C   
3184 O  O   . LYS A 198 ? 0.11940 0.18920 0.26660 0.03800  0.00870  0.00340  1657 LYS A O   
3185 C  CB  . LYS A 198 ? 0.14560 0.22500 0.21120 0.02180  -0.02860 0.01550  1657 LYS A CB  
3186 C  CG  . LYS A 198 ? 0.21170 0.25889 0.25250 0.01750  -0.05130 0.00040  1657 LYS A CG  
3187 C  CD  . LYS A 198 ? 0.25000 0.27049 0.26360 0.01650  -0.02990 -0.00280 1657 LYS A CD  
3188 C  CE  . LYS A 198 ? 0.24439 0.26490 0.26760 0.00060  -0.00040 -0.00250 1657 LYS A CE  
3189 N  NZ  . LYS A 198 ? 0.14030 0.25620 0.22940 -0.01510 0.01040  -0.02750 1657 LYS A NZ  
3203 N  N   . GLY A 199 ? 0.09850 0.18440 0.21840 0.01650  -0.02530 0.01920  1658 GLY A N   
3204 C  CA  . GLY A 199 ? 0.11010 0.18020 0.24960 -0.00180 -0.02260 0.01730  1658 GLY A CA  
3205 C  C   . GLY A 199 ? 0.11020 0.16670 0.26270 0.00990  -0.05080 0.01930  1658 GLY A C   
3206 O  O   . GLY A 199 ? 0.10680 0.16950 0.30800 -0.01640 -0.04370 0.02280  1658 GLY A O   
3210 N  N   . GLU A 200 ? 0.12650 0.16180 0.24240 0.02270  -0.02040 0.00780  1659 GLU A N   
3211 C  CA  . GLU A 200 ? 0.12860 0.16560 0.20350 0.01960  -0.01550 -0.01170 1659 GLU A CA  
3212 C  C   . GLU A 200 ? 0.09900 0.15650 0.20220 0.00530  -0.01710 -0.00970 1659 GLU A C   
3213 O  O   . GLU A 200 ? 0.10080 0.15270 0.18900 -0.00520 -0.02610 -0.02470 1659 GLU A O   
3214 C  CB  . GLU A 200 ? 0.13480 0.18380 0.28000 0.05030  0.01630  -0.01290 1659 GLU A CB  
3215 C  CG  . GLU A 200 ? 0.20710 0.20450 0.29290 0.04630  -0.02600 -0.04480 1659 GLU A CG  
3216 C  CD  . GLU A 200 ? 0.31130 0.22190 0.34160 0.05740  -0.04470 -0.06920 1659 GLU A CD  
3217 O  OE1 . GLU A 200 ? 0.30850 0.21160 0.37850 0.04440  -0.04950 -0.07250 1659 GLU A OE1 
3218 O  OE2 . GLU A 200 ? 0.36910 0.26129 0.40630 0.04320  -0.06130 -0.04360 1659 GLU A OE2 
3225 N  N   . VAL A 201 ? 0.09300 0.14630 0.19930 0.00290  -0.00790 -0.00220 1660 VAL A N   
3226 C  CA  . VAL A 201 ? 0.08580 0.14790 0.16950 0.01210  -0.01240 -0.00590 1660 VAL A CA  
3227 C  C   . VAL A 201 ? 0.10790 0.14150 0.17030 0.00270  -0.01420 -0.01630 1660 VAL A C   
3228 O  O   . VAL A 201 ? 0.10090 0.13020 0.19050 -0.00060 -0.00300 -0.00030 1660 VAL A O   
3229 C  CB  . VAL A 201 ? 0.09110 0.15040 0.19090 0.01280  -0.01560 -0.00800 1660 VAL A CB  
3230 C  CG1 . VAL A 201 ? 0.11650 0.15340 0.22700 0.00200  -0.00670 0.00620  1660 VAL A CG1 
3231 C  CG2 . VAL A 201 ? 0.11410 0.15300 0.20470 0.01010  -0.00030 0.00360  1660 VAL A CG2 
3241 N  N   . ARG A 202 ? 0.09200 0.13380 0.18410 0.00280  -0.02190 -0.00630 1661 ARG A N   
3242 C  CA  . ARG A 202 ? 0.09770 0.13450 0.18920 0.00410  -0.02140 -0.01720 1661 ARG A CA  
3243 C  C   . ARG A 202 ? 0.11260 0.12930 0.21980 0.00420  -0.02210 -0.02900 1661 ARG A C   
3244 O  O   . ARG A 202 ? 0.12340 0.13060 0.28620 0.00900  -0.04130 -0.02250 1661 ARG A O   
3245 C  CB  . ARG A 202 ? 0.17409 0.15480 0.18530 0.00400  -0.02520 0.00500  1661 ARG A CB  
3246 C  CG  . ARG A 202 ? 0.18130 0.18440 0.19640 -0.00690 -0.01300 -0.00080 1661 ARG A CG  
3247 C  CD  . ARG A 202 ? 0.17290 0.21050 0.22250 -0.00020 0.01140  -0.02820 1661 ARG A CD  
3248 N  NE  . ARG A 202 ? 0.19750 0.24579 0.24920 -0.00180 0.02000  -0.05980 1661 ARG A NE  
3249 C  CZ  . ARG A 202 ? 0.18950 0.26400 0.29500 0.02700  0.03940  -0.06220 1661 ARG A CZ  
3250 N  NH1 . ARG A 202 ? 0.19920 0.25260 0.29380 0.03990  0.03800  -0.03980 1661 ARG A NH1 
3251 N  NH2 . ARG A 202 ? 0.20310 0.29589 0.34930 0.02610  0.05640  -0.06270 1661 ARG A NH2 
3265 N  N   . PRO A 203 ? 0.08890 0.12850 0.20100 0.01150  -0.01650 -0.03400 1662 PRO A N   
3266 C  CA  . PRO A 203 ? 0.10540 0.13020 0.20540 0.01130  -0.00590 -0.01350 1662 PRO A CA  
3267 C  C   . PRO A 203 ? 0.10710 0.12330 0.17490 0.01460  0.03280  -0.01150 1662 PRO A C   
3268 O  O   . PRO A 203 ? 0.11520 0.12660 0.17080 0.01080  0.01500  -0.01640 1662 PRO A O   
3269 C  CB  . PRO A 203 ? 0.11540 0.14610 0.19850 -0.00500 0.01310  -0.00220 1662 PRO A CB  
3270 C  CG  . PRO A 203 ? 0.11370 0.15890 0.21840 0.01850  0.01480  -0.02260 1662 PRO A CG  
3271 C  CD  . PRO A 203 ? 0.11080 0.15969 0.21010 0.02750  -0.01220 -0.03160 1662 PRO A CD  
3279 N  N   . GLU A 204 ? 0.12610 0.12880 0.14900 0.01420  0.01270  -0.00600 1663 GLU A N   
3280 C  CA  A GLU A 204 ? 0.15070 0.14080 0.15510 0.03500  -0.04290 0.00300  1663 GLU A CA  
3281 C  CA  B GLU A 204 ? 0.13430 0.13770 0.13900 0.02290  -0.01430 -0.00140 1663 GLU A CA  
3282 C  C   . GLU A 204 ? 0.12790 0.14070 0.13070 0.02460  -0.01570 0.00210  1663 GLU A C   
3283 O  O   . GLU A 204 ? 0.11220 0.15230 0.18830 0.02400  -0.01690 -0.00020 1663 GLU A O   
3284 C  CB  A GLU A 204 ? 0.16910 0.14960 0.20330 0.03130  -0.03350 0.01250  1663 GLU A CB  
3285 C  CB  B GLU A 204 ? 0.13370 0.14220 0.14550 0.01620  -0.01200 -0.00040 1663 GLU A CB  
3286 C  CG  A GLU A 204 ? 0.22970 0.17300 0.25580 0.03980  -0.02400 0.00610  1663 GLU A CG  
3287 C  CG  B GLU A 204 ? 0.16480 0.15220 0.15670 0.01120  -0.02470 -0.00590 1663 GLU A CG  
3288 C  CD  A GLU A 204 ? 0.26860 0.19169 0.31310 0.05550  0.01510  0.02020  1663 GLU A CD  
3289 C  CD  B GLU A 204 ? 0.19340 0.16310 0.16200 0.00780  -0.02210 -0.00130 1663 GLU A CD  
3290 O  OE1 A GLU A 204 ? 0.30210 0.19940 0.34280 0.08420  0.04700  0.03660  1663 GLU A OE1 
3291 O  OE1 B GLU A 204 ? 0.20410 0.17340 0.15000 0.01740  -0.04220 -0.00050 1663 GLU A OE1 
3292 O  OE2 A GLU A 204 ? 0.25950 0.18120 0.30810 0.04470  -0.00920 0.02630  1663 GLU A OE2 
3293 O  OE2 B GLU A 204 ? 0.21750 0.16100 0.16470 0.00500  -0.02360 0.00330  1663 GLU A OE2 
3306 N  N   . LEU A 205 ? 0.12170 0.13690 0.14240 0.01960  -0.02620 0.00070  1664 LEU A N   
3307 C  CA  . LEU A 205 ? 0.14110 0.14360 0.16400 0.01010  -0.02550 -0.00070 1664 LEU A CA  
3308 C  C   . LEU A 205 ? 0.14850 0.14740 0.16210 0.00120  -0.01280 -0.00530 1664 LEU A C   
3309 O  O   . LEU A 205 ? 0.15320 0.14450 0.19480 0.01010  0.01540  -0.01370 1664 LEU A O   
3310 C  CB  . LEU A 205 ? 0.14310 0.14880 0.17500 0.01490  0.01460  0.00270  1664 LEU A CB  
3311 C  CG  . LEU A 205 ? 0.15800 0.15670 0.13910 0.02100  0.01420  -0.00540 1664 LEU A CG  
3312 C  CD1 . LEU A 205 ? 0.16000 0.17679 0.16060 0.02420  -0.02570 0.00820  1664 LEU A CD1 
3313 C  CD2 . LEU A 205 ? 0.17030 0.15700 0.16600 0.02080  0.01260  -0.02710 1664 LEU A CD2 
3325 N  N   . GLY A 206 ? 0.12840 0.15070 0.20580 0.00750  0.00860  0.01490  1665 GLY A N   
3326 C  CA  . GLY A 206 ? 0.13370 0.16760 0.23020 0.00300  -0.01730 0.00810  1665 GLY A CA  
3327 C  C   . GLY A 206 ? 0.12380 0.17540 0.19010 0.02280  -0.01280 0.01050  1665 GLY A C   
3328 O  O   . GLY A 206 ? 0.12570 0.18090 0.21270 0.01710  -0.02140 0.01570  1665 GLY A O   
3332 N  N   . SER A 207 ? 0.13530 0.16580 0.20240 0.02620  -0.00310 0.00900  1666 SER A N   
3333 C  CA  . SER A 207 ? 0.15680 0.16900 0.21600 0.03280  -0.02280 0.02210  1666 SER A CA  
3334 C  C   . SER A 207 ? 0.16430 0.18220 0.17650 0.02840  -0.02690 0.02930  1666 SER A C   
3335 O  O   . SER A 207 ? 0.14160 0.17520 0.19350 0.03080  -0.02580 0.01540  1666 SER A O   
3336 C  CB  . SER A 207 ? 0.17180 0.16780 0.22320 0.03450  -0.00910 0.01600  1666 SER A CB  
3337 O  OG  . SER A 207 ? 0.15470 0.15910 0.24520 0.02140  -0.00560 0.02230  1666 SER A OG  
3343 N  N   . ARG A 208 ? 0.16330 0.20730 0.19320 0.04880  -0.01520 0.03660  1667 ARG A N   
3344 C  CA  . ARG A 208 ? 0.20040 0.23130 0.18840 0.04850  -0.00120 0.05580  1667 ARG A CA  
3345 C  C   . ARG A 208 ? 0.18870 0.22089 0.21240 0.04340  0.01740  0.05020  1667 ARG A C   
3346 O  O   . ARG A 208 ? 0.18550 0.21930 0.23170 0.06200  0.01280  0.04920  1667 ARG A O   
3347 C  CB  . ARG A 208 ? 0.23160 0.25989 0.21600 0.03760  0.00930  0.05740  1667 ARG A CB  
3350 N  N   . GLN A 209 ? 0.18210 0.19300 0.21770 0.04880  -0.00560 0.05470  1668 GLN A N   
3351 C  CA  . GLN A 209 ? 0.20020 0.17620 0.23020 0.03530  -0.00760 0.05390  1668 GLN A CA  
3352 C  C   . GLN A 209 ? 0.16520 0.15780 0.21020 0.01290  -0.01310 0.03800  1668 GLN A C   
3353 O  O   . GLN A 209 ? 0.16700 0.14620 0.20470 0.01110  -0.00040 0.04120  1668 GLN A O   
3354 C  CB  . GLN A 209 ? 0.27900 0.20520 0.26440 0.04720  -0.03220 0.07640  1668 GLN A CB  
3355 C  CG  . GLN A 209 ? 0.38139 0.26859 0.34670 0.05130  -0.02460 0.06700  1668 GLN A CG  
3356 C  CD  . GLN A 209 ? 0.42580 0.31619 0.37580 0.07170  -0.00090 0.06800  1668 GLN A CD  
3357 O  OE1 . GLN A 209 ? 0.37420 0.31110 0.37730 0.13270  0.07090  0.09630  1668 GLN A OE1 
3358 N  NE2 . GLN A 209 ? 0.48040 0.34609 0.42270 0.04410  -0.00770 0.05290  1668 GLN A NE2 
3367 N  N   . ASP A 210 ? 0.14770 0.15530 0.17130 0.02210  -0.00220 0.04330  1669 ASP A N   
3368 C  CA  . ASP A 210 ? 0.14590 0.13850 0.12530 0.01260  -0.02490 0.02810  1669 ASP A CA  
3369 C  C   . ASP A 210 ? 0.14690 0.13350 0.16910 0.00790  -0.02280 0.01190  1669 ASP A C   
3370 O  O   . ASP A 210 ? 0.12950 0.12560 0.16840 0.01160  -0.01110 0.02260  1669 ASP A O   
3371 C  CB  . ASP A 210 ? 0.12150 0.13150 0.15060 0.02610  -0.00020 0.01510  1669 ASP A CB  
3372 C  CG  . ASP A 210 ? 0.12600 0.13380 0.18580 0.01980  0.00030  0.00060  1669 ASP A CG  
3373 O  OD1 . ASP A 210 ? 0.12360 0.13650 0.21720 0.01380  -0.01020 -0.00820 1669 ASP A OD1 
3374 O  OD2 . ASP A 210 ? 0.14760 0.13660 0.19990 0.02290  -0.00450 -0.01080 1669 ASP A OD2 
3379 N  N   . VAL A 211 ? 0.15550 0.13710 0.16610 0.02910  0.00570  0.00000  1670 VAL A N   
3380 C  CA  . VAL A 211 ? 0.13610 0.14620 0.16990 0.01340  -0.00800 0.01400  1670 VAL A CA  
3381 C  C   . VAL A 211 ? 0.13230 0.15140 0.16140 0.01280  -0.00130 0.01860  1670 VAL A C   
3382 O  O   . VAL A 211 ? 0.12300 0.16260 0.18070 0.03170  0.00780  -0.00270 1670 VAL A O   
3383 C  CB  . VAL A 211 ? 0.14400 0.15720 0.16880 0.01820  -0.02410 0.00380  1670 VAL A CB  
3384 C  CG1 . VAL A 211 ? 0.16470 0.17140 0.15650 0.00550  -0.02780 -0.00890 1670 VAL A CG1 
3385 C  CG2 . VAL A 211 ? 0.14350 0.16510 0.15850 0.01770  -0.03880 0.01290  1670 VAL A CG2 
3395 N  N   . GLU A 212 ? 0.14660 0.16150 0.16870 0.01330  0.00170  0.03740  1671 GLU A N   
3396 C  CA  A GLU A 212 ? 0.16910 0.17540 0.17990 0.01070  0.01180  0.02090  1671 GLU A CA  
3397 C  CA  B GLU A 212 ? 0.17120 0.17250 0.17850 0.01800  0.01660  0.02560  1671 GLU A CA  
3398 C  C   . GLU A 212 ? 0.16980 0.16090 0.17270 0.01530  0.00380  0.01470  1671 GLU A C   
3399 O  O   . GLU A 212 ? 0.17540 0.16190 0.20970 0.01680  0.03100  0.02160  1671 GLU A O   
3400 C  CB  A GLU A 212 ? 0.20390 0.20870 0.18860 0.01310  0.00580  0.03370  1671 GLU A CB  
3401 C  CB  B GLU A 212 ? 0.21700 0.19970 0.17680 0.03230  0.01910  0.05100  1671 GLU A CB  
3402 C  CG  A GLU A 212 ? 0.24070 0.24070 0.22310 0.00570  -0.01100 0.04660  1671 GLU A CG  
3403 C  CG  B GLU A 212 ? 0.26770 0.22290 0.23050 0.03060  0.00220  0.06310  1671 GLU A CG  
3404 C  CD  A GLU A 212 ? 0.28330 0.27290 0.25950 0.01420  -0.04350 0.05090  1671 GLU A CD  
3405 C  CD  B GLU A 212 ? 0.33080 0.24520 0.24700 0.01780  0.02170  0.07940  1671 GLU A CD  
3406 O  OE1 A GLU A 212 ? 0.31020 0.27970 0.30130 0.01560  -0.04100 0.06910  1671 GLU A OE1 
3407 O  OE1 B GLU A 212 ? 0.38400 0.25080 0.24770 0.01180  0.01560  0.09840  1671 GLU A OE1 
3408 O  OE2 A GLU A 212 ? 0.29920 0.29149 0.21700 0.02540  -0.06250 0.06600  1671 GLU A OE2 
3409 O  OE2 B GLU A 212 ? 0.34710 0.25890 0.28760 0.01420  0.03730  0.08660  1671 GLU A OE2 
3422 N  N   . ALA A 213 ? 0.16310 0.14100 0.18790 0.01410  -0.01960 0.03430  1672 ALA A N   
3423 C  CA  . ALA A 213 ? 0.15460 0.13880 0.19080 0.02480  -0.02040 0.02370  1672 ALA A CA  
3424 C  C   . ALA A 213 ? 0.15040 0.12980 0.17070 0.01240  0.01400  0.01060  1672 ALA A C   
3425 O  O   . ALA A 213 ? 0.13380 0.12250 0.20320 0.01720  0.01620  0.00930  1672 ALA A O   
3426 C  CB  . ALA A 213 ? 0.15230 0.14460 0.18360 0.03450  0.00530  0.01480  1672 ALA A CB  
3432 N  N   . LEU A 214 ? 0.13780 0.12460 0.16910 0.00510  0.01090  0.01420  1673 LEU A N   
3433 C  CA  . LEU A 214 ? 0.14790 0.12490 0.14570 0.00160  -0.00660 0.00250  1673 LEU A CA  
3434 C  C   . LEU A 214 ? 0.16789 0.13200 0.12810 -0.00350 -0.01470 -0.00430 1673 LEU A C   
3435 O  O   . LEU A 214 ? 0.13360 0.13200 0.17860 0.01790  -0.01470 0.00470  1673 LEU A O   
3436 C  CB  . LEU A 214 ? 0.13540 0.13990 0.09090 -0.01100 -0.01820 0.00550  1673 LEU A CB  
3437 C  CG  . LEU A 214 ? 0.14370 0.14240 0.10100 -0.00970 -0.00250 0.00100  1673 LEU A CG  
3438 C  CD1 . LEU A 214 ? 0.14230 0.15550 0.10020 -0.01120 0.00530  0.00620  1673 LEU A CD1 
3439 C  CD2 . LEU A 214 ? 0.17220 0.15859 0.09990 -0.01220 0.00980  -0.00600 1673 LEU A CD2 
3451 N  N   . TRP A 215 ? 0.14900 0.13810 0.12410 0.00660  0.00570  0.00210  1674 TRP A N   
3452 C  CA  . TRP A 215 ? 0.15140 0.15500 0.11210 0.00200  0.00490  -0.00900 1674 TRP A CA  
3453 C  C   . TRP A 215 ? 0.13190 0.15250 0.11290 0.00500  0.00790  -0.01180 1674 TRP A C   
3454 O  O   . TRP A 215 ? 0.14940 0.15930 0.18350 0.00070  0.01610  0.01650  1674 TRP A O   
3455 C  CB  . TRP A 215 ? 0.16300 0.16789 0.09270 -0.01370 0.00310  -0.00930 1674 TRP A CB  
3456 C  CG  . TRP A 215 ? 0.13710 0.15790 0.12630 -0.00710 0.00910  -0.00500 1674 TRP A CG  
3457 C  CD1 . TRP A 215 ? 0.13910 0.16280 0.15290 -0.00770 0.01070  0.00680  1674 TRP A CD1 
3458 C  CD2 . TRP A 215 ? 0.15450 0.15620 0.15240 0.00340  0.00530  -0.00150 1674 TRP A CD2 
3459 N  NE1 . TRP A 215 ? 0.12990 0.16150 0.15250 -0.01280 -0.00550 -0.00540 1674 TRP A NE1 
3460 C  CE2 . TRP A 215 ? 0.15210 0.15880 0.17850 0.00500  0.01030  -0.00980 1674 TRP A CE2 
3461 C  CE3 . TRP A 215 ? 0.18400 0.16540 0.14790 0.00500  -0.00540 -0.02520 1674 TRP A CE3 
3462 C  CZ2 . TRP A 215 ? 0.16630 0.16830 0.17180 -0.01540 0.01010  -0.01740 1674 TRP A CZ2 
3463 C  CZ3 . TRP A 215 ? 0.17590 0.17799 0.16760 0.01320  0.00600  -0.04130 1674 TRP A CZ3 
3464 C  CH2 . TRP A 215 ? 0.18110 0.17250 0.17670 -0.00280 -0.01200 -0.04020 1674 TRP A CH2 
3475 N  N   . GLU A 216 ? 0.13650 0.15620 0.16200 0.01440  0.01030  0.00610  1675 GLU A N   
3476 C  CA  A GLU A 216 ? 0.14790 0.16620 0.16020 0.00520  0.00940  0.02010  1675 GLU A CA  
3477 C  CA  B GLU A 216 ? 0.13620 0.16150 0.15300 -0.00350 0.00670  0.01520  1675 GLU A CA  
3478 C  C   . GLU A 216 ? 0.13900 0.16060 0.16210 -0.00490 0.00190  0.01320  1675 GLU A C   
3479 O  O   . GLU A 216 ? 0.14150 0.17210 0.19340 -0.00880 0.00890  0.01850  1675 GLU A O   
3480 C  CB  A GLU A 216 ? 0.18860 0.19010 0.21820 0.01570  0.01320  0.04930  1675 GLU A CB  
3481 C  CB  B GLU A 216 ? 0.15410 0.17510 0.18900 -0.01060 0.00470  0.03320  1675 GLU A CB  
3482 C  CG  A GLU A 216 ? 0.25260 0.21990 0.25070 0.01670  -0.00310 0.06260  1675 GLU A CG  
3483 C  CG  B GLU A 216 ? 0.18510 0.19570 0.21890 -0.02140 -0.01050 0.03020  1675 GLU A CG  
3484 C  CD  A GLU A 216 ? 0.31920 0.25090 0.30930 0.02080  -0.01310 0.05210  1675 GLU A CD  
3485 C  CD  B GLU A 216 ? 0.24500 0.22710 0.26770 -0.03770 -0.01220 0.02410  1675 GLU A CD  
3486 O  OE1 A GLU A 216 ? 0.34220 0.25150 0.33250 0.00180  0.00620  0.03340  1675 GLU A OE1 
3487 O  OE1 B GLU A 216 ? 0.28130 0.24220 0.27800 -0.05520 0.00800  0.02840  1675 GLU A OE1 
3488 O  OE2 A GLU A 216 ? 0.35540 0.27259 0.32360 0.03010  -0.02900 0.07690  1675 GLU A OE2 
3489 O  OE2 B GLU A 216 ? 0.28210 0.24389 0.32010 -0.03140 -0.00130 0.02250  1675 GLU A OE2 
3502 N  N   . ASN A 217 ? 0.13810 0.14230 0.15540 0.00970  0.01100  0.01190  1676 ASN A N   
3503 C  CA  . ASN A 217 ? 0.12390 0.13790 0.13840 0.00840  0.02670  0.01180  1676 ASN A CA  
3504 C  C   . ASN A 217 ? 0.13190 0.13150 0.13990 -0.01130 0.02050  0.01050  1676 ASN A C   
3505 O  O   . ASN A 217 ? 0.12870 0.12230 0.18810 0.00230  0.01370  0.00200  1676 ASN A O   
3506 C  CB  . ASN A 217 ? 0.14220 0.13530 0.18060 0.01310  0.03880  0.01570  1676 ASN A CB  
3507 C  CG  . ASN A 217 ? 0.14920 0.14210 0.20560 -0.00600 0.02030  0.00990  1676 ASN A CG  
3508 O  OD1 . ASN A 217 ? 0.17520 0.15330 0.23150 -0.02740 0.01610  -0.00900 1676 ASN A OD1 
3509 N  ND2 . ASN A 217 ? 0.18510 0.13220 0.21790 -0.00210 -0.01140 0.01300  1676 ASN A ND2 
3516 N  N   . MET A 218 ? 0.15250 0.12690 0.12230 -0.00910 0.01740  0.00520  1677 MET A N   
3517 C  CA  . MET A 218 ? 0.14320 0.11810 0.15110 -0.01390 0.01340  0.00430  1677 MET A CA  
3518 C  C   . MET A 218 ? 0.13300 0.11419 0.15850 -0.00990 0.01280  -0.00430 1677 MET A C   
3519 O  O   . MET A 218 ? 0.14610 0.09790 0.14630 0.00070  0.00660  -0.01190 1677 MET A O   
3520 C  CB  . MET A 218 ? 0.17740 0.13100 0.16120 0.00100  -0.00330 -0.00550 1677 MET A CB  
3521 C  CG  . MET A 218 ? 0.18680 0.14309 0.19070 -0.01360 0.00830  -0.00580 1677 MET A CG  
3522 S  SD  . MET A 218 ? 0.17680 0.13390 0.20160 -0.02890 -0.03560 0.01080  1677 MET A SD  
3523 C  CE  . MET A 218 ? 0.21710 0.16979 0.24680 -0.01390 -0.07630 0.04030  1677 MET A CE  
3533 N  N   . ALA A 219 ? 0.13890 0.11040 0.15260 -0.01370 0.02290  -0.00240 1678 ALA A N   
3534 C  CA  . ALA A 219 ? 0.13250 0.12310 0.19120 -0.01350 0.03710  -0.00110 1678 ALA A CA  
3535 C  C   . ALA A 219 ? 0.13980 0.12400 0.17600 -0.01020 0.03620  -0.00650 1678 ALA A C   
3536 O  O   . ALA A 219 ? 0.13790 0.14169 0.21420 0.01000  0.00480  0.01150  1678 ALA A O   
3537 C  CB  . ALA A 219 ? 0.15170 0.14179 0.25150 -0.03040 0.03700  0.00930  1678 ALA A CB  
3543 N  N   . VAL A 220 ? 0.13370 0.10590 0.15080 -0.01910 0.02030  -0.01200 1679 VAL A N   
3544 C  CA  . VAL A 220 ? 0.13770 0.10830 0.15630 0.00180  0.01860  0.00840  1679 VAL A CA  
3545 C  C   . VAL A 220 ? 0.12550 0.10660 0.10520 -0.00260 0.00220  0.00440  1679 VAL A C   
3546 O  O   . VAL A 220 ? 0.12280 0.11240 0.13040 -0.01110 -0.00920 -0.00950 1679 VAL A O   
3547 C  CB  . VAL A 220 ? 0.16230 0.11330 0.16230 0.00090  0.01860  0.00440  1679 VAL A CB  
3548 C  CG1 . VAL A 220 ? 0.15140 0.13019 0.20900 -0.00290 0.00130  0.01050  1679 VAL A CG1 
3549 C  CG2 . VAL A 220 ? 0.20460 0.11480 0.20080 -0.00420 0.01990  0.00130  1679 VAL A CG2 
3559 N  N   . ILE A 221 ? 0.11440 0.10500 0.13180 -0.00310 0.01140  0.00560  1680 ILE A N   
3560 C  CA  . ILE A 221 ? 0.10160 0.10450 0.15020 0.00590  -0.00360 -0.00540 1680 ILE A CA  
3561 C  C   . ILE A 221 ? 0.10240 0.10890 0.08990 -0.00510 0.00870  0.00530  1680 ILE A C   
3562 O  O   . ILE A 221 ? 0.12190 0.11400 0.12070 -0.00310 0.02200  0.01940  1680 ILE A O   
3563 C  CB  . ILE A 221 ? 0.10350 0.09970 0.14990 -0.00180 -0.00710 -0.00050 1680 ILE A CB  
3564 C  CG1 . ILE A 221 ? 0.09430 0.11540 0.16120 -0.00270 -0.00540 -0.00990 1680 ILE A CG1 
3565 C  CG2 . ILE A 221 ? 0.12020 0.09360 0.15900 -0.01010 -0.00690 -0.00650 1680 ILE A CG2 
3566 C  CD1 . ILE A 221 ? 0.13110 0.12520 0.18580 0.01370  0.00010  -0.00650 1680 ILE A CD1 
3578 N  N   . ASP A 222 ? 0.10560 0.10430 0.11410 0.01300  0.01530  -0.01470 1681 ASP A N   
3579 C  CA  . ASP A 222 ? 0.12539 0.09850 0.12220 0.00660  0.02260  -0.00500 1681 ASP A CA  
3580 C  C   . ASP A 222 ? 0.10090 0.09850 0.14050 0.01100  0.00170  -0.00050 1681 ASP A C   
3581 O  O   . ASP A 222 ? 0.09690 0.09820 0.14560 0.00660  0.01180  -0.00470 1681 ASP A O   
3582 C  CB  . ASP A 222 ? 0.10530 0.09930 0.14440 0.01650  0.01530  -0.01070 1681 ASP A CB  
3583 C  CG  . ASP A 222 ? 0.10470 0.10800 0.17230 -0.02200 0.02550  -0.01040 1681 ASP A CG  
3584 O  OD1 . ASP A 222 ? 0.09910 0.12090 0.23350 -0.01610 0.02430  -0.04020 1681 ASP A OD1 
3585 O  OD2 . ASP A 222 ? 0.10810 0.11110 0.14120 -0.01250 0.01620  -0.01240 1681 ASP A OD2 
3590 N  N   . CYS A 223 ? 0.07420 0.10430 0.15580 0.00350  0.00500  -0.00990 1682 CYS A N   
3591 C  CA  . CYS A 223 ? 0.08740 0.10490 0.14210 -0.00160 0.00220  -0.01370 1682 CYS A CA  
3592 C  C   . CYS A 223 ? 0.07880 0.10240 0.15290 -0.00980 -0.00600 -0.00680 1682 CYS A C   
3593 O  O   . CYS A 223 ? 0.09590 0.09640 0.13860 0.00170  0.01500  -0.00050 1682 CYS A O   
3594 C  CB  . CYS A 223 ? 0.08860 0.12569 0.15160 0.01260  -0.01280 -0.00400 1682 CYS A CB  
3595 S  SG  . CYS A 223 ? 0.10539 0.12150 0.16920 0.00480  -0.00230 0.00520  1682 CYS A SG  
3601 N  N   . PHE A 224 ? 0.09180 0.10420 0.13440 0.00020  0.00230  -0.02750 1683 PHE A N   
3602 C  CA  . PHE A 224 ? 0.09840 0.11440 0.10670 0.00080  0.01510  -0.01050 1683 PHE A CA  
3603 C  C   . PHE A 224 ? 0.09810 0.10600 0.12440 -0.00400 -0.00280 -0.00180 1683 PHE A C   
3604 O  O   . PHE A 224 ? 0.10780 0.11170 0.17120 0.01800  0.01960  0.02190  1683 PHE A O   
3605 C  CB  . PHE A 224 ? 0.09620 0.11940 0.14100 0.01350  0.02060  -0.00070 1683 PHE A CB  
3606 C  CG  . PHE A 224 ? 0.09110 0.11510 0.14360 0.01340  -0.00040 -0.00540 1683 PHE A CG  
3607 C  CD1 . PHE A 224 ? 0.12490 0.10430 0.16000 0.01330  0.00050  0.00120  1683 PHE A CD1 
3608 C  CD2 . PHE A 224 ? 0.09300 0.12570 0.14790 0.00990  0.01150  -0.01730 1683 PHE A CD2 
3609 C  CE1 . PHE A 224 ? 0.12660 0.11510 0.14940 0.01220  -0.01860 0.00420  1683 PHE A CE1 
3610 C  CE2 . PHE A 224 ? 0.11360 0.12820 0.14690 -0.00220 0.03320  0.00520  1683 PHE A CE2 
3611 C  CZ  . PHE A 224 ? 0.11740 0.12979 0.13510 -0.00540 -0.00750 -0.00010 1683 PHE A CZ  
3621 N  N   . ALA A 225 ? 0.07730 0.09430 0.13890 -0.00620 0.00850  -0.00420 1684 ALA A N   
3622 C  CA  . ALA A 225 ? 0.10829 0.10220 0.14970 -0.00640 0.01310  -0.00560 1684 ALA A CA  
3623 C  C   . ALA A 225 ? 0.08960 0.09940 0.13510 -0.00440 0.00160  0.00970  1684 ALA A C   
3624 O  O   . ALA A 225 ? 0.09550 0.10600 0.18800 0.00560  0.00580  0.02020  1684 ALA A O   
3625 C  CB  . ALA A 225 ? 0.10000 0.11270 0.15750 -0.00510 0.01600  -0.00290 1684 ALA A CB  
3631 N  N   . SER A 226 ? 0.09270 0.09960 0.15320 0.00180  0.00390  0.00530  1685 SER A N   
3632 C  CA  . SER A 226 ? 0.09640 0.11240 0.16100 0.00130  -0.01090 -0.00920 1685 SER A CA  
3633 C  C   . SER A 226 ? 0.10630 0.11340 0.12520 -0.01250 0.00460  -0.01680 1685 SER A C   
3634 O  O   . SER A 226 ? 0.08450 0.11680 0.14800 -0.00090 -0.00230 0.00120  1685 SER A O   
3635 C  CB  . SER A 226 ? 0.10250 0.11290 0.15670 0.00940  0.01130  -0.01180 1685 SER A CB  
3636 O  OG  . SER A 226 ? 0.08640 0.12270 0.19720 -0.01080 -0.00070 -0.01480 1685 SER A OG  
3642 N  N   . ASP A 227 ? 0.08790 0.11600 0.13980 -0.01120 0.00280  -0.01140 1686 ASP A N   
3643 C  CA  . ASP A 227 ? 0.09360 0.10900 0.10210 -0.00720 -0.00290 -0.00570 1686 ASP A CA  
3644 C  C   . ASP A 227 ? 0.08840 0.10990 0.13040 -0.00980 0.00160  -0.00360 1686 ASP A C   
3645 O  O   . ASP A 227 ? 0.07860 0.11470 0.15580 -0.00070 0.00310  -0.00950 1686 ASP A O   
3646 C  CB  . ASP A 227 ? 0.08340 0.11790 0.12320 -0.00410 0.00100  -0.01550 1686 ASP A CB  
3647 C  CG  . ASP A 227 ? 0.08470 0.11620 0.16260 -0.01010 -0.01170 0.00200  1686 ASP A CG  
3648 O  OD1 . ASP A 227 ? 0.08570 0.12240 0.17770 -0.01150 -0.00930 -0.00830 1686 ASP A OD1 
3649 O  OD2 . ASP A 227 ? 0.09620 0.11510 0.19530 0.01320  0.01200  0.00510  1686 ASP A OD2 
3654 N  N   . HIS A 228 ? 0.07910 0.10510 0.14850 -0.01530 0.00030  -0.00470 1687 HIS A N   
3655 C  CA  . HIS A 228 ? 0.09550 0.11640 0.17440 -0.00490 -0.00710 -0.00610 1687 HIS A CA  
3656 C  C   . HIS A 228 ? 0.08130 0.12280 0.13460 -0.01590 -0.01100 0.00920  1687 HIS A C   
3657 O  O   . HIS A 228 ? 0.08670 0.12740 0.15170 -0.00690 0.01290  -0.00800 1687 HIS A O   
3658 C  CB  . HIS A 228 ? 0.08990 0.12050 0.16200 -0.01000 0.01440  -0.00790 1687 HIS A CB  
3659 C  CG  . HIS A 228 ? 0.08110 0.12180 0.16520 -0.00800 0.00360  -0.02720 1687 HIS A CG  
3660 N  ND1 . HIS A 228 ? 0.10280 0.12420 0.19600 -0.01770 0.00160  -0.02060 1687 HIS A ND1 
3661 C  CD2 . HIS A 228 ? 0.09530 0.12550 0.12720 0.00050  -0.00110 -0.02500 1687 HIS A CD2 
3662 C  CE1 . HIS A 228 ? 0.10950 0.13200 0.13400 -0.02360 -0.01960 -0.03410 1687 HIS A CE1 
3663 N  NE2 . HIS A 228 ? 0.12040 0.13200 0.14150 0.00230  0.00680  -0.03260 1687 HIS A NE2 
3671 N  N   . ALA A 229 ? 0.08170 0.12230 0.13740 -0.01120 -0.02150 -0.00010 1688 ALA A N   
3672 C  CA  . ALA A 229 ? 0.08630 0.12630 0.14910 -0.00680 -0.00850 -0.00060 1688 ALA A CA  
3673 C  C   . ALA A 229 ? 0.08640 0.12780 0.15760 0.00360  -0.00470 -0.00870 1688 ALA A C   
3674 O  O   . ALA A 229 ? 0.09570 0.12030 0.18050 -0.00380 0.00370  -0.00990 1688 ALA A O   
3675 C  CB  . ALA A 229 ? 0.08940 0.13040 0.14410 -0.00550 -0.01210 -0.00900 1688 ALA A CB  
3681 N  N   . PRO A 230 ? 0.08580 0.13180 0.16900 -0.00960 0.00700  0.00720  1689 PRO A N   
3682 C  CA  . PRO A 230 ? 0.08590 0.13760 0.14830 -0.02140 0.00810  -0.01710 1689 PRO A CA  
3683 C  C   . PRO A 230 ? 0.08310 0.13910 0.13700 -0.02190 0.00020  -0.01940 1689 PRO A C   
3684 O  O   . PRO A 230 ? 0.09690 0.13690 0.15550 -0.00890 -0.00080 -0.00520 1689 PRO A O   
3685 C  CB  . PRO A 230 ? 0.09820 0.13390 0.17640 -0.02530 0.00010  -0.01640 1689 PRO A CB  
3686 C  CG  . PRO A 230 ? 0.09750 0.12830 0.16870 -0.01970 0.00090  0.00030  1689 PRO A CG  
3687 C  CD  . PRO A 230 ? 0.09780 0.12800 0.16510 -0.00410 0.00270  0.01160  1689 PRO A CD  
3695 N  N   . HIS A 231 ? 0.08240 0.14959 0.15700 -0.01980 -0.00520 -0.01510 1690 HIS A N   
3696 C  CA  . HIS A 231 ? 0.08350 0.13870 0.18550 -0.00870 -0.00070 -0.01760 1690 HIS A CA  
3697 C  C   . HIS A 231 ? 0.07600 0.14810 0.14300 -0.00780 0.00240  -0.01600 1690 HIS A C   
3698 O  O   . HIS A 231 ? 0.08130 0.15160 0.15670 -0.00580 0.00040  -0.02440 1690 HIS A O   
3699 C  CB  . HIS A 231 ? 0.09480 0.13190 0.17380 -0.01110 -0.00410 -0.02070 1690 HIS A CB  
3700 C  CG  . HIS A 231 ? 0.11470 0.13130 0.17780 0.00050  -0.01420 -0.00860 1690 HIS A CG  
3701 N  ND1 . HIS A 231 ? 0.09780 0.13120 0.19530 0.00310  0.00280  -0.01960 1690 HIS A ND1 
3702 C  CD2 . HIS A 231 ? 0.10570 0.12850 0.17810 -0.00640 -0.00110 -0.00930 1690 HIS A CD2 
3703 C  CE1 . HIS A 231 ? 0.10860 0.13820 0.18890 -0.00810 -0.02170 -0.02140 1690 HIS A CE1 
3704 N  NE2 . HIS A 231 ? 0.11180 0.13910 0.16850 0.00110  -0.00600 -0.01500 1690 HIS A NE2 
3712 N  N   . THR A 232 ? 0.08200 0.16280 0.15490 -0.00180 -0.00880 -0.01140 1691 THR A N   
3713 C  CA  . THR A 232 ? 0.08580 0.17100 0.18750 -0.00140 -0.01260 -0.01160 1691 THR A CA  
3714 C  C   . THR A 232 ? 0.07020 0.17640 0.18330 -0.01530 -0.01630 -0.03200 1691 THR A C   
3715 O  O   . THR A 232 ? 0.08920 0.16670 0.22320 -0.00390 0.00800  -0.04090 1691 THR A O   
3716 C  CB  . THR A 232 ? 0.09650 0.18090 0.23420 -0.01380 -0.01460 -0.00510 1691 THR A CB  
3717 O  OG1 . THR A 232 ? 0.10190 0.19000 0.22870 -0.02140 0.00770  -0.01460 1691 THR A OG1 
3718 C  CG2 . THR A 232 ? 0.12240 0.19050 0.24900 -0.02530 -0.00750 0.00460  1691 THR A CG2 
3726 N  N   . LEU A 233 ? 0.09700 0.18630 0.17370 -0.01580 -0.01490 -0.02490 1692 LEU A N   
3727 C  CA  . LEU A 233 ? 0.09820 0.19550 0.18870 -0.00950 -0.02140 -0.00260 1692 LEU A CA  
3728 C  C   . LEU A 233 ? 0.09620 0.17860 0.20520 -0.01890 -0.00500 0.00500  1692 LEU A C   
3729 O  O   . LEU A 233 ? 0.10350 0.16220 0.23870 -0.01250 -0.02150 -0.00120 1692 LEU A O   
3730 C  CB  . LEU A 233 ? 0.10780 0.21690 0.19390 0.00690  -0.00990 -0.01170 1692 LEU A CB  
3731 C  CG  . LEU A 233 ? 0.12950 0.22480 0.18230 0.00610  -0.00960 -0.00490 1692 LEU A CG  
3732 C  CD1 . LEU A 233 ? 0.16340 0.22760 0.19800 0.00670  0.01260  0.01510  1692 LEU A CD1 
3733 C  CD2 . LEU A 233 ? 0.14980 0.22670 0.19880 0.03410  -0.03330 -0.00520 1692 LEU A CD2 
3745 N  N   . GLU A 234 ? 0.09640 0.17940 0.22020 -0.01120 0.00060  0.00180  1693 GLU A N   
3746 C  CA  . GLU A 234 ? 0.10090 0.19280 0.22820 -0.02200 0.00910  -0.00490 1693 GLU A CA  
3747 C  C   . GLU A 234 ? 0.10640 0.18510 0.19470 -0.01070 -0.00720 -0.02100 1693 GLU A C   
3748 O  O   . GLU A 234 ? 0.10900 0.18630 0.21090 0.00560  -0.00170 -0.00700 1693 GLU A O   
3749 C  CB  . GLU A 234 ? 0.10760 0.22270 0.24990 -0.03820 0.01290  -0.01880 1693 GLU A CB  
3750 C  CG  . GLU A 234 ? 0.15680 0.26380 0.28810 0.00090  -0.00530 0.00220  1693 GLU A CG  
3751 C  CD  . GLU A 234 ? 0.20000 0.29260 0.34870 0.01860  0.03410  0.00290  1693 GLU A CD  
3752 O  OE1 . GLU A 234 ? 0.21880 0.30720 0.38750 0.01440  0.02680  0.01340  1693 GLU A OE1 
3753 O  OE2 . GLU A 234 ? 0.24410 0.30450 0.38740 0.00820  0.04010  0.00350  1693 GLU A OE2 
3760 N  N   . GLU A 235 ? 0.08440 0.18180 0.20080 -0.01770 -0.00280 -0.01930 1694 GLU A N   
3761 C  CA  . GLU A 235 ? 0.09250 0.17530 0.18930 0.00020  -0.01230 -0.00630 1694 GLU A CA  
3762 C  C   . GLU A 235 ? 0.09460 0.17200 0.16880 -0.00230 -0.00650 -0.01160 1694 GLU A C   
3763 O  O   . GLU A 235 ? 0.10760 0.17190 0.19330 -0.00070 0.01700  -0.01480 1694 GLU A O   
3764 C  CB  . GLU A 235 ? 0.09750 0.16380 0.18790 0.00750  0.00610  -0.01780 1694 GLU A CB  
3765 C  CG  . GLU A 235 ? 0.12810 0.17810 0.18450 0.01700  0.02210  0.00660  1694 GLU A CG  
3766 C  CD  . GLU A 235 ? 0.13890 0.18630 0.17830 0.00760  0.03100  0.01060  1694 GLU A CD  
3767 O  OE1 . GLU A 235 ? 0.10900 0.17990 0.19600 0.00160  0.00750  0.00080  1694 GLU A OE1 
3768 O  OE2 . GLU A 235 ? 0.15270 0.19500 0.20760 0.00600  0.02330  0.02010  1694 GLU A OE2 
3775 N  N   . LYS A 236 ? 0.10490 0.16780 0.18340 0.00010  -0.00270 -0.01100 1695 LYS A N   
3776 C  CA  . LYS A 236 ? 0.09340 0.17130 0.14180 -0.00220 0.01420  0.00820  1695 LYS A CA  
3777 C  C   . LYS A 236 ? 0.09360 0.18210 0.19520 0.00890  0.00370  0.00410  1695 LYS A C   
3778 O  O   . LYS A 236 ? 0.10800 0.17870 0.22480 0.01420  0.01300  0.00260  1695 LYS A O   
3779 C  CB  . LYS A 236 ? 0.09880 0.16420 0.13390 -0.01820 -0.00080 0.00550  1695 LYS A CB  
3780 C  CG  . LYS A 236 ? 0.09140 0.16410 0.18890 -0.00990 -0.01140 0.00440  1695 LYS A CG  
3781 C  CD  . LYS A 236 ? 0.09920 0.15870 0.19280 0.01380  0.01080  0.01610  1695 LYS A CD  
3782 C  CE  . LYS A 236 ? 0.08490 0.15900 0.17360 0.01170  -0.01060 -0.01400 1695 LYS A CE  
3783 N  NZ  . LYS A 236 ? 0.08490 0.16340 0.16730 0.00980  0.00130  -0.01650 1695 LYS A NZ  
3797 N  N   . CYS A 237 ? 0.09990 0.20670 0.17880 0.01180  -0.00240 0.00850  1696 CYS A N   
3798 C  CA  . CYS A 237 ? 0.10560 0.25110 0.19380 0.02390  -0.01260 0.01080  1696 CYS A CA  
3799 C  C   . CYS A 237 ? 0.08670 0.22820 0.20490 0.00900  0.01660  0.00120  1696 CYS A C   
3800 O  O   . CYS A 237 ? 0.09870 0.22970 0.24940 0.02410  0.00660  -0.00540 1696 CYS A O   
3801 C  CB  . CYS A 237 ? 0.12550 0.34210 0.19810 0.07170  -0.00180 -0.00660 1696 CYS A CB  
3802 S  SG  . CYS A 237 ? 0.19989 0.41999 0.20130 0.12880  -0.01140 -0.01760 1696 CYS A SG  
3808 N  N   . GLY A 238 ? 0.10510 0.23630 0.18510 0.01910  0.01810  -0.00080 1697 GLY A N   
3809 C  CA  . GLY A 238 ? 0.12840 0.25730 0.21040 0.02740  -0.00330 0.02120  1697 GLY A CA  
3810 C  C   . GLY A 238 ? 0.14050 0.27450 0.21780 0.02560  0.00280  0.00510  1697 GLY A C   
3811 O  O   . GLY A 238 ? 0.19460 0.26150 0.25300 0.01630  0.02620  -0.02220 1697 GLY A O   
3815 N  N   . SER A 239 ? 0.15210 0.30450 0.23920 0.03550  0.00980  -0.00040 1698 SER A N   
3816 C  CA  . SER A 239 ? 0.22430 0.33980 0.26630 0.03580  0.02680  -0.02000 1698 SER A CA  
3817 C  C   . SER A 239 ? 0.21750 0.36520 0.28650 0.04110  0.00660  -0.02440 1698 SER A C   
3818 O  O   . SER A 239 ? 0.28659 0.37190 0.37500 0.04600  0.00910  -0.04800 1698 SER A O   
3819 C  CB  . SER A 239 ? 0.29130 0.35440 0.29340 0.04120  0.07390  0.00400  1698 SER A CB  
3820 O  OG  . SER A 239 ? 0.33390 0.37299 0.37800 0.04450  0.10380  0.00840  1698 SER A OG  
3826 N  N   . ARG A 240 ? 0.13850 0.38089 0.23140 0.03920  0.01680  -0.00960 1699 ARG A N   
3827 C  CA  . ARG A 240 ? 0.18960 0.37310 0.24760 0.04600  0.02540  -0.00030 1699 ARG A CA  
3828 C  C   . ARG A 240 ? 0.15530 0.33920 0.24090 0.04950  0.03220  0.00910  1699 ARG A C   
3829 O  O   . ARG A 240 ? 0.15790 0.35360 0.28750 0.03700  0.00440  0.05840  1699 ARG A O   
3830 C  CB  . ARG A 240 ? 0.25219 0.38600 0.25580 0.04690  0.05990  0.00270  1699 ARG A CB  
3833 N  N   . PRO A 241 ? 0.14230 0.28720 0.25110 0.03800  0.01430  -0.02910 1700 PRO A N   
3834 C  CA  . PRO A 241 ? 0.11860 0.25130 0.26540 0.02060  0.01980  -0.04850 1700 PRO A CA  
3835 C  C   . PRO A 241 ? 0.11630 0.21980 0.26250 -0.01230 0.01500  -0.03220 1700 PRO A C   
3836 O  O   . PRO A 241 ? 0.14110 0.21340 0.29490 -0.03020 0.01090  -0.02120 1700 PRO A O   
3837 C  CB  . PRO A 241 ? 0.13170 0.27220 0.26790 0.01860  -0.02190 -0.04100 1700 PRO A CB  
3838 C  CG  . PRO A 241 ? 0.22089 0.28999 0.31870 0.01100  -0.02690 -0.02500 1700 PRO A CG  
3839 C  CD  . PRO A 241 ? 0.22199 0.28390 0.28110 0.03110  0.02670  -0.03820 1700 PRO A CD  
3847 N  N   . PRO A 242 ? 0.09660 0.19390 0.21010 -0.00110 0.01610  -0.02910 1701 PRO A N   
3848 C  CA  . PRO A 242 ? 0.11610 0.18290 0.16290 -0.00480 -0.00360 -0.01710 1701 PRO A CA  
3849 C  C   . PRO A 242 ? 0.09740 0.16610 0.16460 -0.00770 -0.00580 -0.01430 1701 PRO A C   
3850 O  O   . PRO A 242 ? 0.10630 0.17530 0.17130 -0.01320 -0.00280 -0.00600 1701 PRO A O   
3851 C  CB  . PRO A 242 ? 0.13690 0.18490 0.19330 -0.00250 0.01780  -0.01520 1701 PRO A CB  
3852 C  CG  . PRO A 242 ? 0.16309 0.18580 0.22660 0.00630  -0.01010 -0.02340 1701 PRO A CG  
3853 C  CD  . PRO A 242 ? 0.12650 0.18410 0.21200 -0.00710 0.00810  -0.01810 1701 PRO A CD  
3861 N  N   . PRO A 243 ? 0.10040 0.16900 0.17220 -0.00360 -0.00320 -0.02470 1702 PRO A N   
3862 C  CA  . PRO A 243 ? 0.09850 0.15890 0.16890 -0.00540 0.01730  -0.01660 1702 PRO A CA  
3863 C  C   . PRO A 243 ? 0.07850 0.15000 0.14940 0.00020  -0.00090 -0.00250 1702 PRO A C   
3864 O  O   . PRO A 243 ? 0.09790 0.14320 0.20530 -0.00750 -0.00480 0.00380  1702 PRO A O   
3865 C  CB  . PRO A 243 ? 0.10940 0.17310 0.20170 -0.01370 0.00420  -0.01020 1702 PRO A CB  
3866 C  CG  . PRO A 243 ? 0.11210 0.18750 0.22670 -0.00950 0.00500  -0.00990 1702 PRO A CG  
3867 C  CD  . PRO A 243 ? 0.12740 0.19389 0.20890 -0.01120 0.01410  -0.01340 1702 PRO A CD  
3875 N  N   . GLY A 244 ? 0.08490 0.13340 0.14510 0.00470  -0.00770 -0.01540 1703 GLY A N   
3876 C  CA  . GLY A 244 ? 0.09360 0.12710 0.14230 0.01260  0.00310  -0.01630 1703 GLY A CA  
3877 C  C   . GLY A 244 ? 0.09180 0.12400 0.14230 0.01770  0.01290  -0.00410 1703 GLY A C   
3878 O  O   . GLY A 244 ? 0.08400 0.14059 0.17790 0.00550  0.00240  -0.01510 1703 GLY A O   
3882 N  N   . PHE A 245 ? 0.09270 0.12690 0.16120 0.00390  0.00640  -0.00250 1704 PHE A N   
3883 C  CA  . PHE A 245 ? 0.09360 0.14189 0.14090 0.00330  -0.00660 -0.00390 1704 PHE A CA  
3884 C  C   . PHE A 245 ? 0.07980 0.13150 0.16470 -0.00600 0.01650  -0.00700 1704 PHE A C   
3885 O  O   . PHE A 245 ? 0.08020 0.12530 0.16680 -0.00190 0.01380  -0.00760 1704 PHE A O   
3886 C  CB  . PHE A 245 ? 0.08690 0.14420 0.16760 -0.00510 -0.00060 -0.01180 1704 PHE A CB  
3887 C  CG  . PHE A 245 ? 0.09650 0.14000 0.13480 0.00570  0.01210  -0.00030 1704 PHE A CG  
3888 C  CD1 . PHE A 245 ? 0.10130 0.14560 0.17530 0.00430  -0.00730 0.00910  1704 PHE A CD1 
3889 C  CD2 . PHE A 245 ? 0.13150 0.13500 0.15740 -0.00130 0.02540  -0.01850 1704 PHE A CD2 
3890 C  CE1 . PHE A 245 ? 0.09970 0.16179 0.20090 0.00350  -0.01140 -0.00130 1704 PHE A CE1 
3891 C  CE2 . PHE A 245 ? 0.13770 0.13380 0.20700 -0.00320 0.02230  -0.00710 1704 PHE A CE2 
3892 C  CZ  . PHE A 245 ? 0.13780 0.14610 0.20450 0.00410  0.01460  -0.00480 1704 PHE A CZ  
3902 N  N   . PRO A 246 ? 0.08370 0.13630 0.15190 -0.00240 -0.00880 -0.00140 1705 PRO A N   
3903 C  CA  . PRO A 246 ? 0.10600 0.13120 0.14950 -0.00910 0.00260  -0.00280 1705 PRO A CA  
3904 C  C   . PRO A 246 ? 0.11550 0.12750 0.14560 -0.01450 0.00810  -0.00880 1705 PRO A C   
3905 O  O   . PRO A 246 ? 0.10470 0.13840 0.16350 -0.00220 0.01100  -0.01420 1705 PRO A O   
3906 C  CB  . PRO A 246 ? 0.10110 0.14400 0.18900 -0.01330 0.00220  -0.01070 1705 PRO A CB  
3907 C  CG  . PRO A 246 ? 0.11550 0.14870 0.21260 -0.01630 -0.02400 -0.01870 1705 PRO A CG  
3908 C  CD  . PRO A 246 ? 0.09890 0.14910 0.20140 -0.00190 -0.02950 -0.00440 1705 PRO A CD  
3916 N  N   . GLY A 247 ? 0.11110 0.12400 0.12890 0.00370  0.01340  -0.01120 1706 GLY A N   
3917 C  CA  . GLY A 247 ? 0.11370 0.11800 0.13920 0.01380  -0.00500 -0.01000 1706 GLY A CA  
3918 C  C   . GLY A 247 ? 0.10470 0.10900 0.17050 -0.02330 0.01030  -0.00670 1706 GLY A C   
3919 O  O   . GLY A 247 ? 0.10240 0.11540 0.16220 -0.01170 0.01390  -0.00610 1706 GLY A O   
3923 N  N   . LEU A 248 ? 0.09550 0.11510 0.15780 -0.02300 0.01400  -0.01960 1707 LEU A N   
3924 C  CA  . LEU A 248 ? 0.08860 0.12090 0.17050 -0.00920 0.00830  -0.02530 1707 LEU A CA  
3925 C  C   . LEU A 248 ? 0.09380 0.11130 0.17880 -0.00830 0.02060  -0.02440 1707 LEU A C   
3926 O  O   . LEU A 248 ? 0.10540 0.11870 0.18090 -0.01570 0.00610  -0.03100 1707 LEU A O   
3927 C  CB  . LEU A 248 ? 0.10180 0.12150 0.15480 -0.01460 0.00370  -0.02240 1707 LEU A CB  
3928 C  CG  . LEU A 248 ? 0.11500 0.12350 0.16420 0.00330  -0.00870 -0.00760 1707 LEU A CG  
3929 C  CD1 . LEU A 248 ? 0.12300 0.12250 0.16580 -0.00010 0.01900  -0.00250 1707 LEU A CD1 
3930 C  CD2 . LEU A 248 ? 0.11840 0.13490 0.19240 -0.00480 -0.03460 -0.02650 1707 LEU A CD2 
3942 N  N   . GLU A 249 ? 0.09500 0.12010 0.19040 -0.01550 -0.00440 -0.02940 1708 GLU A N   
3943 C  CA  . GLU A 249 ? 0.10730 0.13270 0.18190 -0.00370 0.00120  -0.01650 1708 GLU A CA  
3944 C  C   . GLU A 249 ? 0.12500 0.14440 0.17440 -0.00910 0.00090  -0.02490 1708 GLU A C   
3945 O  O   . GLU A 249 ? 0.16110 0.14090 0.18380 -0.00780 0.00070  -0.02470 1708 GLU A O   
3946 C  CB  . GLU A 249 ? 0.12560 0.12920 0.16550 -0.00740 -0.01460 -0.01700 1708 GLU A CB  
3947 C  CG  . GLU A 249 ? 0.11080 0.12050 0.15300 -0.00030 -0.03270 -0.02930 1708 GLU A CG  
3948 C  CD  . GLU A 249 ? 0.11480 0.13420 0.16450 -0.01620 -0.01780 -0.04460 1708 GLU A CD  
3949 O  OE1 . GLU A 249 ? 0.13360 0.12950 0.17770 -0.02380 0.01510  -0.02520 1708 GLU A OE1 
3950 O  OE2 . GLU A 249 ? 0.12150 0.14120 0.20310 -0.01780 -0.00250 -0.04010 1708 GLU A OE2 
3957 N  N   . THR A 250 ? 0.10940 0.14630 0.15090 -0.01620 0.00140  -0.01550 1709 THR A N   
3958 C  CA  . THR A 250 ? 0.11450 0.15170 0.13250 -0.01680 -0.00270 -0.02180 1709 THR A CA  
3959 C  C   . THR A 250 ? 0.10900 0.14530 0.11280 -0.00350 -0.00290 -0.01490 1709 THR A C   
3960 O  O   . THR A 250 ? 0.10700 0.15350 0.12200 -0.01000 0.00420  -0.01430 1709 THR A O   
3961 C  CB  . THR A 250 ? 0.11210 0.14890 0.15770 -0.00100 -0.00320 -0.00840 1709 THR A CB  
3962 O  OG1 . THR A 250 ? 0.10880 0.14750 0.17460 0.01320  0.00930  -0.01230 1709 THR A OG1 
3963 C  CG2 . THR A 250 ? 0.13150 0.14800 0.18020 -0.00920 0.00700  0.00160  1709 THR A CG2 
3971 N  N   . MET A 251 ? 0.10560 0.12500 0.13810 -0.00930 -0.01090 -0.01800 1710 MET A N   
3972 C  CA  . MET A 251 ? 0.10710 0.12160 0.14410 -0.01010 0.00980  -0.02440 1710 MET A CA  
3973 C  C   . MET A 251 ? 0.10070 0.12530 0.14040 -0.01860 0.00460  -0.01760 1710 MET A C   
3974 O  O   . MET A 251 ? 0.11060 0.12490 0.15130 -0.00750 0.00570  -0.00400 1710 MET A O   
3975 C  CB  . MET A 251 ? 0.10410 0.12970 0.14160 -0.00390 -0.00580 -0.01670 1710 MET A CB  
3976 C  CG  . MET A 251 ? 0.10520 0.14449 0.16350 -0.01090 0.00200  -0.01400 1710 MET A CG  
3977 S  SD  . MET A 251 ? 0.10459 0.13790 0.18260 0.00500  -0.00540 -0.01040 1710 MET A SD  
3978 C  CE  . MET A 251 ? 0.11090 0.13690 0.21140 -0.00570 -0.01880 -0.00530 1710 MET A CE  
3988 N  N   . LEU A 252 ? 0.09910 0.12890 0.15570 -0.01250 0.01040  -0.03020 1711 LEU A N   
3989 C  CA  . LEU A 252 ? 0.12400 0.12360 0.13290 -0.02080 0.01380  -0.01530 1711 LEU A CA  
3990 C  C   . LEU A 252 ? 0.12240 0.13610 0.14020 -0.01150 0.00370  -0.00740 1711 LEU A C   
3991 O  O   . LEU A 252 ? 0.12800 0.14760 0.15060 -0.00590 -0.00800 -0.00830 1711 LEU A O   
3992 C  CB  . LEU A 252 ? 0.12180 0.12060 0.13230 -0.01630 -0.00580 -0.01550 1711 LEU A CB  
3993 C  CG  . LEU A 252 ? 0.12480 0.13540 0.17600 -0.02020 0.02030  -0.04410 1711 LEU A CG  
3994 C  CD1 . LEU A 252 ? 0.12250 0.14510 0.20350 -0.00620 0.02910  -0.03060 1711 LEU A CD1 
3995 C  CD2 . LEU A 252 ? 0.12280 0.14270 0.20200 -0.00900 0.00520  -0.05210 1711 LEU A CD2 
4007 N  N   . PRO A 253 ? 0.11910 0.15590 0.13910 -0.02210 -0.00530 -0.00440 1712 PRO A N   
4008 C  CA  . PRO A 253 ? 0.12600 0.16440 0.17700 -0.01780 -0.01930 -0.01690 1712 PRO A CA  
4009 C  C   . PRO A 253 ? 0.11650 0.16050 0.11610 -0.01600 0.00350  -0.02060 1712 PRO A C   
4010 O  O   . PRO A 253 ? 0.12710 0.17200 0.14310 -0.00060 0.00650  -0.03220 1712 PRO A O   
4011 C  CB  . PRO A 253 ? 0.14060 0.18410 0.22920 -0.02670 -0.03210 -0.01400 1712 PRO A CB  
4012 C  CG  . PRO A 253 ? 0.14150 0.19459 0.18250 -0.02720 -0.01520 -0.01380 1712 PRO A CG  
4013 C  CD  . PRO A 253 ? 0.11810 0.17730 0.13140 -0.00910 -0.00580 -0.01660 1712 PRO A CD  
4021 N  N   . LEU A 254 ? 0.11820 0.15420 0.12290 -0.01100 -0.00420 -0.02120 1713 LEU A N   
4022 C  CA  . LEU A 254 ? 0.11530 0.15550 0.13440 -0.01520 0.00080  -0.01190 1713 LEU A CA  
4023 C  C   . LEU A 254 ? 0.11780 0.15200 0.13530 -0.01780 -0.00110 -0.01140 1713 LEU A C   
4024 O  O   . LEU A 254 ? 0.12810 0.16300 0.13280 -0.01090 0.00280  0.00190  1713 LEU A O   
4025 C  CB  . LEU A 254 ? 0.11510 0.15130 0.15030 0.00470  -0.01260 -0.01000 1713 LEU A CB  
4026 C  CG  . LEU A 254 ? 0.11580 0.16180 0.14450 0.00280  -0.01040 0.00710  1713 LEU A CG  
4027 C  CD1 . LEU A 254 ? 0.10880 0.16850 0.13710 -0.00080 -0.00680 0.01150  1713 LEU A CD1 
4028 C  CD2 . LEU A 254 ? 0.11510 0.18619 0.17790 0.00350  -0.01100 0.00930  1713 LEU A CD2 
4040 N  N   . LEU A 255 ? 0.10460 0.14780 0.15500 -0.00380 -0.01260 -0.01280 1714 LEU A N   
4041 C  CA  . LEU A 255 ? 0.11720 0.15240 0.13130 -0.00150 -0.00060 -0.02320 1714 LEU A CA  
4042 C  C   . LEU A 255 ? 0.12510 0.16150 0.15680 -0.00660 -0.00970 -0.01100 1714 LEU A C   
4043 O  O   . LEU A 255 ? 0.11130 0.16420 0.17930 -0.02350 0.00650  -0.00750 1714 LEU A O   
4044 C  CB  . LEU A 255 ? 0.11650 0.16970 0.11930 -0.01180 -0.00800 -0.00310 1714 LEU A CB  
4045 C  CG  . LEU A 255 ? 0.12300 0.18490 0.11600 -0.02290 -0.00410 -0.01200 1714 LEU A CG  
4046 C  CD1 . LEU A 255 ? 0.12680 0.18750 0.11330 -0.02360 -0.00150 -0.00750 1714 LEU A CD1 
4047 C  CD2 . LEU A 255 ? 0.12990 0.18930 0.16230 -0.01780 -0.01370 -0.03110 1714 LEU A CD2 
4059 N  N   . LEU A 256 ? 0.11970 0.16460 0.16130 -0.00150 0.00350  -0.03140 1715 LEU A N   
4060 C  CA  . LEU A 256 ? 0.12330 0.17550 0.19610 0.00100  0.01840  -0.02340 1715 LEU A CA  
4061 C  C   . LEU A 256 ? 0.14360 0.18860 0.14820 -0.01190 0.00060  -0.02150 1715 LEU A C   
4062 O  O   . LEU A 256 ? 0.15200 0.19570 0.15130 -0.01160 -0.00360 -0.02910 1715 LEU A O   
4063 C  CB  . LEU A 256 ? 0.13390 0.16840 0.20390 0.00930  0.01590  -0.02970 1715 LEU A CB  
4064 C  CG  . LEU A 256 ? 0.18190 0.16890 0.19160 0.01180  0.02290  -0.03080 1715 LEU A CG  
4065 C  CD1 . LEU A 256 ? 0.21340 0.15630 0.21340 -0.00070 0.01720  -0.02270 1715 LEU A CD1 
4066 C  CD2 . LEU A 256 ? 0.18860 0.17200 0.21910 0.02250  0.02660  -0.02940 1715 LEU A CD2 
4078 N  N   . THR A 257 ? 0.13590 0.20040 0.15400 -0.00210 -0.02640 -0.01550 1716 THR A N   
4079 C  CA  . THR A 257 ? 0.14290 0.19880 0.14530 -0.01690 0.01270  -0.01640 1716 THR A CA  
4080 C  C   . THR A 257 ? 0.14240 0.18510 0.12010 -0.02480 -0.00110 0.01020  1716 THR A C   
4081 O  O   . THR A 257 ? 0.15520 0.19720 0.18410 -0.03520 -0.00370 0.00300  1716 THR A O   
4082 C  CB  . THR A 257 ? 0.13860 0.22000 0.15650 -0.01370 0.01150  -0.00090 1716 THR A CB  
4083 O  OG1 . THR A 257 ? 0.13570 0.23510 0.17540 -0.02640 -0.00070 0.00680  1716 THR A OG1 
4084 C  CG2 . THR A 257 ? 0.15950 0.22560 0.16140 -0.01430 -0.01130 0.00470  1716 THR A CG2 
4092 N  N   . ALA A 258 ? 0.14320 0.17890 0.14440 -0.00910 -0.00510 -0.00730 1717 ALA A N   
4093 C  CA  . ALA A 258 ? 0.14260 0.16890 0.14930 -0.01720 -0.00590 -0.00020 1717 ALA A CA  
4094 C  C   . ALA A 258 ? 0.14380 0.17500 0.16000 -0.01880 -0.00160 0.00880  1717 ALA A C   
4095 O  O   . ALA A 258 ? 0.15830 0.18130 0.18210 -0.02330 0.01540  0.00460  1717 ALA A O   
4096 C  CB  . ALA A 258 ? 0.15320 0.17210 0.17770 -0.00620 0.00960  0.01020  1717 ALA A CB  
4102 N  N   . VAL A 259 ? 0.14770 0.18040 0.13670 -0.01650 0.04190  -0.00110 1718 VAL A N   
4103 C  CA  . VAL A 259 ? 0.15230 0.18940 0.16780 -0.02670 0.02820  -0.02870 1718 VAL A CA  
4104 C  C   . VAL A 259 ? 0.20510 0.21220 0.16930 -0.03370 0.04230  -0.01630 1718 VAL A C   
4105 O  O   . VAL A 259 ? 0.21550 0.21330 0.16910 -0.03770 0.07370  -0.00970 1718 VAL A O   
4106 C  CB  . VAL A 259 ? 0.12970 0.18360 0.19250 -0.01300 0.06410  -0.00710 1718 VAL A CB  
4107 C  CG1 . VAL A 259 ? 0.17380 0.19560 0.21240 -0.00220 0.04390  -0.02130 1718 VAL A CG1 
4108 C  CG2 . VAL A 259 ? 0.16870 0.17190 0.17930 0.01640  0.03950  -0.00650 1718 VAL A CG2 
4118 N  N   . SER A 260 ? 0.24770 0.23340 0.21770 -0.05400 0.03740  -0.02190 1719 SER A N   
4119 C  CA  A SER A 260 ? 0.27780 0.24770 0.22120 -0.05900 0.03570  -0.01390 1719 SER A CA  
4120 C  CA  B SER A 260 ? 0.28810 0.24640 0.22780 -0.05640 0.03200  -0.02130 1719 SER A CA  
4121 C  C   . SER A 260 ? 0.30430 0.26210 0.21170 -0.07360 0.04470  -0.00410 1719 SER A C   
4122 O  O   . SER A 260 ? 0.35820 0.27620 0.21750 -0.08280 0.04820  0.00980  1719 SER A O   
4123 C  CB  A SER A 260 ? 0.28440 0.24750 0.23900 -0.05130 0.02540  -0.01600 1719 SER A CB  
4124 C  CB  B SER A 260 ? 0.31730 0.24330 0.26990 -0.04370 0.01150  -0.03960 1719 SER A CB  
4125 O  OG  A SER A 260 ? 0.29520 0.25230 0.24890 -0.04830 0.03040  -0.00640 1719 SER A OG  
4126 O  OG  B SER A 260 ? 0.35380 0.24660 0.29430 -0.04870 0.01080  -0.03770 1719 SER A OG  
4137 N  N   . GLU A 261 ? 0.28560 0.26830 0.19370 -0.07110 0.02910  -0.01710 1720 GLU A N   
4138 C  CA  . GLU A 261 ? 0.28870 0.27930 0.22110 -0.06010 -0.00350 -0.00740 1720 GLU A CA  
4139 C  C   . GLU A 261 ? 0.29420 0.27390 0.20120 -0.06230 -0.00760 0.01380  1720 GLU A C   
4140 O  O   . GLU A 261 ? 0.30640 0.28590 0.24630 -0.05820 -0.03000 0.03330  1720 GLU A O   
4141 C  CB  . GLU A 261 ? 0.28000 0.28430 0.25490 -0.04800 -0.01430 -0.01150 1720 GLU A CB  
4142 C  CG  . GLU A 261 ? 0.29120 0.30030 0.26240 -0.03900 -0.02480 -0.02440 1720 GLU A CG  
4143 C  CD  . GLU A 261 ? 0.29670 0.31910 0.34210 -0.03110 -0.00840 -0.03430 1720 GLU A CD  
4144 O  OE1 . GLU A 261 ? 0.29900 0.32800 0.36080 -0.02710 0.01760  -0.05170 1720 GLU A OE1 
4145 O  OE2 . GLU A 261 ? 0.28480 0.33090 0.40370 -0.03620 -0.01860 -0.02900 1720 GLU A OE2 
4152 N  N   . GLY A 262 ? 0.25220 0.25380 0.20570 -0.06080 0.01680  -0.00220 1721 GLY A N   
4153 C  CA  . GLY A 262 ? 0.24860 0.23770 0.20640 -0.04230 0.01990  0.00960  1721 GLY A CA  
4154 C  C   . GLY A 262 ? 0.24110 0.22020 0.20860 -0.04240 0.00140  0.01240  1721 GLY A C   
4155 O  O   . GLY A 262 ? 0.27080 0.21020 0.25570 -0.06820 0.01030  0.01280  1721 GLY A O   
4159 N  N   . ARG A 263 ? 0.17960 0.21200 0.18360 -0.01790 -0.02480 0.03220  1722 ARG A N   
4160 C  CA  . ARG A 263 ? 0.19240 0.20530 0.20880 -0.01260 -0.02170 0.01440  1722 ARG A CA  
4161 C  C   . ARG A 263 ? 0.17900 0.20310 0.19820 -0.00890 -0.00630 0.01470  1722 ARG A C   
4162 O  O   . ARG A 263 ? 0.19570 0.20690 0.22640 0.01510  -0.03470 0.01130  1722 ARG A O   
4163 C  CB  . ARG A 263 ? 0.19050 0.21090 0.20320 0.01230  -0.01730 0.02270  1722 ARG A CB  
4164 C  CG  . ARG A 263 ? 0.22389 0.23230 0.23380 0.03370  -0.00940 0.00360  1722 ARG A CG  
4165 C  CD  . ARG A 263 ? 0.19000 0.24250 0.23530 0.04100  -0.00620 -0.01340 1722 ARG A CD  
4166 N  NE  . ARG A 263 ? 0.20040 0.24720 0.24530 0.05170  -0.01380 -0.00030 1722 ARG A NE  
4167 C  CZ  . ARG A 263 ? 0.24450 0.25490 0.23000 0.06220  -0.03170 0.02660  1722 ARG A CZ  
4168 N  NH1 . ARG A 263 ? 0.23760 0.26330 0.24680 0.04180  -0.02500 0.01170  1722 ARG A NH1 
4169 N  NH2 . ARG A 263 ? 0.27900 0.25890 0.24600 0.06510  -0.02950 0.02080  1722 ARG A NH2 
4183 N  N   . LEU A 264 ? 0.16240 0.19840 0.19550 0.01350  0.02730  0.01940  1723 LEU A N   
4184 C  CA  . LEU A 264 ? 0.17940 0.18020 0.16320 0.01230  0.02340  0.01040  1723 LEU A CA  
4185 C  C   . LEU A 264 ? 0.16570 0.17950 0.15490 0.00200  0.02460  0.00250  1723 LEU A C   
4186 O  O   . LEU A 264 ? 0.14780 0.18290 0.17030 -0.01370 0.00280  0.00680  1723 LEU A O   
4187 C  CB  . LEU A 264 ? 0.15800 0.16530 0.17510 0.01510  0.00160  -0.01380 1723 LEU A CB  
4188 C  CG  . LEU A 264 ? 0.15220 0.16580 0.21370 -0.00140 0.00500  -0.02610 1723 LEU A CG  
4189 C  CD1 . LEU A 264 ? 0.18270 0.17560 0.26070 0.02000  0.01540  -0.00670 1723 LEU A CD1 
4190 C  CD2 . LEU A 264 ? 0.15450 0.16470 0.21660 -0.00100 -0.00450 -0.01350 1723 LEU A CD2 
4202 N  N   . SER A 265 ? 0.14140 0.17180 0.16450 0.00770  -0.00380 0.00370  1724 SER A N   
4203 C  CA  . SER A 265 ? 0.15390 0.17370 0.13520 0.00690  0.01080  0.00400  1724 SER A CA  
4204 C  C   . SER A 265 ? 0.13840 0.16750 0.12790 -0.01150 -0.00130 -0.00410 1724 SER A C   
4205 O  O   . SER A 265 ? 0.12900 0.15020 0.18270 -0.00780 0.00640  0.01650  1724 SER A O   
4206 C  CB  . SER A 265 ? 0.14470 0.17320 0.14010 -0.01630 0.03720  0.00310  1724 SER A CB  
4207 O  OG  . SER A 265 ? 0.15220 0.17680 0.11510 -0.02100 0.01540  0.00720  1724 SER A OG  
4213 N  N   . LEU A 266 ? 0.14340 0.17449 0.12510 -0.01740 0.01030  -0.02330 1725 LEU A N   
4214 C  CA  . LEU A 266 ? 0.13930 0.16150 0.15950 -0.01040 0.01710  -0.01700 1725 LEU A CA  
4215 C  C   . LEU A 266 ? 0.13480 0.13830 0.09060 -0.00220 0.04080  -0.02320 1725 LEU A C   
4216 O  O   . LEU A 266 ? 0.12690 0.15559 0.12350 -0.01100 0.02990  -0.02020 1725 LEU A O   
4217 C  CB  . LEU A 266 ? 0.13910 0.17190 0.18470 -0.00650 0.00620  -0.00520 1725 LEU A CB  
4218 C  CG  . LEU A 266 ? 0.18440 0.17540 0.18350 -0.00260 -0.00490 -0.01540 1725 LEU A CG  
4219 C  CD1 . LEU A 266 ? 0.23180 0.16270 0.20870 -0.02180 0.01880  -0.03290 1725 LEU A CD1 
4220 C  CD2 . LEU A 266 ? 0.19310 0.18770 0.23100 -0.01020 -0.00850 -0.02930 1725 LEU A CD2 
4232 N  N   . ASP A 267 ? 0.11990 0.14070 0.12500 -0.00210 0.02230  -0.01340 1726 ASP A N   
4233 C  CA  . ASP A 267 ? 0.13630 0.15300 0.08250 -0.01340 0.01600  -0.00590 1726 ASP A CA  
4234 C  C   . ASP A 267 ? 0.11750 0.12520 0.03500 -0.00910 0.01000  0.00720  1726 ASP A C   
4235 O  O   . ASP A 267 ? 0.11970 0.13660 0.06880 -0.00570 0.01840  -0.00100 1726 ASP A O   
4236 C  CB  . ASP A 267 ? 0.14460 0.19080 0.13520 0.01030  0.01660  -0.02270 1726 ASP A CB  
4237 C  CG  . ASP A 267 ? 0.19130 0.24330 0.21150 0.00940  0.02530  -0.03540 1726 ASP A CG  
4238 O  OD1 . ASP A 267 ? 0.16660 0.27879 0.20050 0.05770  0.00580  -0.04290 1726 ASP A OD1 
4239 O  OD2 . ASP A 267 ? 0.22560 0.26109 0.24380 -0.04480 0.00490  -0.05350 1726 ASP A OD2 
4244 N  N   . ASP A 268 ? 0.15920 0.12980 0.12800 -0.00650 0.00820  0.00960  1727 ASP A N   
4245 C  CA  . ASP A 268 ? 0.15520 0.13990 0.15330 0.00400  0.01770  -0.01050 1727 ASP A CA  
4246 C  C   . ASP A 268 ? 0.13500 0.14770 0.10910 0.00830  -0.00130 -0.01390 1727 ASP A C   
4247 O  O   . ASP A 268 ? 0.13110 0.13870 0.12460 0.01590  -0.00010 -0.01440 1727 ASP A O   
4248 C  CB  . ASP A 268 ? 0.17550 0.14150 0.18130 0.00220  0.02520  -0.00540 1727 ASP A CB  
4249 C  CG  . ASP A 268 ? 0.18330 0.14930 0.22920 -0.01010 -0.02030 0.01480  1727 ASP A CG  
4250 O  OD1 . ASP A 268 ? 0.21220 0.16460 0.24640 -0.02930 -0.02970 0.01970  1727 ASP A OD1 
4251 O  OD2 . ASP A 268 ? 0.21270 0.15350 0.20780 -0.00280 0.01060  0.01040  1727 ASP A OD2 
4256 N  N   . LEU A 269 ? 0.11950 0.15420 0.14930 -0.00100 0.00320  -0.01460 1728 LEU A N   
4257 C  CA  A LEU A 269 ? 0.13650 0.15710 0.13960 -0.02120 0.00090  -0.03100 1728 LEU A CA  
4258 C  CA  B LEU A 269 ? 0.12770 0.15170 0.13800 -0.01670 0.00880  -0.01980 1728 LEU A CA  
4259 C  C   . LEU A 269 ? 0.11470 0.14660 0.14720 -0.03040 0.03420  -0.01500 1728 LEU A C   
4260 O  O   . LEU A 269 ? 0.11350 0.14570 0.16550 -0.01220 0.01060  -0.01630 1728 LEU A O   
4261 C  CB  A LEU A 269 ? 0.13940 0.16180 0.14220 -0.02290 0.01420  -0.03870 1728 LEU A CB  
4262 C  CB  B LEU A 269 ? 0.13110 0.14750 0.12840 -0.01400 0.00720  -0.02490 1728 LEU A CB  
4263 C  CG  A LEU A 269 ? 0.15950 0.16240 0.18930 -0.04210 0.01950  -0.03530 1728 LEU A CG  
4264 C  CG  B LEU A 269 ? 0.13810 0.13940 0.13230 -0.02030 0.00580  -0.02920 1728 LEU A CG  
4265 C  CD1 A LEU A 269 ? 0.15070 0.16420 0.24160 -0.02610 0.02230  -0.03440 1728 LEU A CD1 
4266 C  CD1 B LEU A 269 ? 0.14340 0.13470 0.14520 -0.01110 -0.00450 -0.01860 1728 LEU A CD1 
4267 C  CD2 A LEU A 269 ? 0.17940 0.17320 0.22640 -0.06080 0.03020  -0.02120 1728 LEU A CD2 
4268 C  CD2 B LEU A 269 ? 0.13700 0.14070 0.13780 -0.03180 0.01490  -0.04760 1728 LEU A CD2 
4291 N  N   . LEU A 270 ? 0.12040 0.12580 0.16500 -0.02910 0.02240  -0.01820 1729 LEU A N   
4292 C  CA  . LEU A 270 ? 0.14310 0.12340 0.14660 -0.01360 0.02270  -0.02460 1729 LEU A CA  
4293 C  C   . LEU A 270 ? 0.11210 0.10520 0.11040 0.00240  0.01390  -0.00500 1729 LEU A C   
4294 O  O   . LEU A 270 ? 0.13080 0.10510 0.16840 -0.01210 0.00170  -0.00070 1729 LEU A O   
4295 C  CB  . LEU A 270 ? 0.19530 0.12970 0.15980 0.00550  0.01250  -0.02390 1729 LEU A CB  
4296 C  CG  . LEU A 270 ? 0.22540 0.14100 0.17590 -0.00660 0.01450  -0.01940 1729 LEU A CG  
4297 C  CD1 . LEU A 270 ? 0.23350 0.15050 0.23240 0.00260  -0.00070 -0.03050 1729 LEU A CD1 
4298 C  CD2 . LEU A 270 ? 0.23540 0.14310 0.24700 -0.03970 0.04820  -0.02870 1729 LEU A CD2 
4310 N  N   . GLN A 271 ? 0.10240 0.09880 0.12690 0.00350  0.02390  0.00710  1730 GLN A N   
4311 C  CA  . GLN A 271 ? 0.10500 0.10340 0.12510 -0.00270 0.01080  0.00360  1730 GLN A CA  
4312 C  C   . GLN A 271 ? 0.11060 0.10190 0.03650 -0.01040 -0.01230 0.00410  1730 GLN A C   
4313 O  O   . GLN A 271 ? 0.09510 0.10290 0.10560 0.00040  -0.00020 -0.00220 1730 GLN A O   
4314 C  CB  . GLN A 271 ? 0.09410 0.10680 0.19270 -0.00640 0.00630  0.00750  1730 GLN A CB  
4315 C  CG  . GLN A 271 ? 0.09830 0.11260 0.18150 -0.00750 -0.01350 -0.00620 1730 GLN A CG  
4316 C  CD  . GLN A 271 ? 0.12000 0.12500 0.15530 -0.01660 0.00810  -0.00730 1730 GLN A CD  
4317 O  OE1 . GLN A 271 ? 0.09310 0.14029 0.16550 -0.00140 -0.00170 -0.01960 1730 GLN A OE1 
4318 N  NE2 . GLN A 271 ? 0.12270 0.14889 0.17690 0.00240  -0.00540 -0.01280 1730 GLN A NE2 
4327 N  N   . ARG A 272 ? 0.08420 0.11110 0.13370 -0.00360 -0.00820 -0.00650 1731 ARG A N   
4328 C  CA  . ARG A 272 ? 0.07600 0.11240 0.14620 0.00600  -0.01420 -0.00610 1731 ARG A CA  
4329 C  C   . ARG A 272 ? 0.09130 0.11180 0.15060 0.00620  -0.00360 -0.02000 1731 ARG A C   
4330 O  O   . ARG A 272 ? 0.09890 0.10040 0.16230 -0.00080 0.00010  -0.01580 1731 ARG A O   
4331 C  CB  . ARG A 272 ? 0.09250 0.11110 0.13140 -0.00440 -0.00750 -0.00900 1731 ARG A CB  
4332 C  CG  . ARG A 272 ? 0.10370 0.10390 0.15020 0.00470  -0.01560 -0.00590 1731 ARG A CG  
4333 C  CD  . ARG A 272 ? 0.12260 0.10840 0.12940 -0.01050 0.00530  0.00080  1731 ARG A CD  
4334 N  NE  . ARG A 272 ? 0.11440 0.10700 0.15240 0.00380  0.00450  -0.00200 1731 ARG A NE  
4335 C  CZ  . ARG A 272 ? 0.13670 0.10530 0.18910 0.00880  0.02810  -0.00330 1731 ARG A CZ  
4336 N  NH1 . ARG A 272 ? 0.14580 0.11410 0.20750 -0.00400 0.06510  -0.01300 1731 ARG A NH1 
4337 N  NH2 . ARG A 272 ? 0.17330 0.11340 0.20310 -0.01060 0.04030  -0.01620 1731 ARG A NH2 
4351 N  N   . LEU A 273 ? 0.07910 0.12199 0.12860 -0.00010 0.00430  -0.02920 1732 LEU A N   
4352 C  CA  . LEU A 273 ? 0.08860 0.11670 0.13410 -0.01760 0.00570  -0.02060 1732 LEU A CA  
4353 C  C   . LEU A 273 ? 0.09450 0.11120 0.17280 -0.00670 0.00260  -0.02890 1732 LEU A C   
4354 O  O   . LEU A 273 ? 0.08720 0.10580 0.19480 -0.01420 0.00910  -0.02050 1732 LEU A O   
4355 C  CB  . LEU A 273 ? 0.10710 0.11250 0.15710 -0.00500 0.01310  -0.02410 1732 LEU A CB  
4356 C  CG  . LEU A 273 ? 0.10460 0.14920 0.18590 0.00030  -0.00540 -0.03210 1732 LEU A CG  
4357 C  CD1 . LEU A 273 ? 0.13540 0.18679 0.19860 0.01060  -0.06840 -0.00920 1732 LEU A CD1 
4358 C  CD2 . LEU A 273 ? 0.10850 0.17219 0.21100 0.02260  0.02230  -0.04870 1732 LEU A CD2 
4370 N  N   . HIS A 274 ? 0.08510 0.09740 0.20090 -0.00760 0.00770  -0.01560 1733 HIS A N   
4371 C  CA  . HIS A 274 ? 0.08150 0.10619 0.18310 0.00910  0.00940  -0.01600 1733 HIS A CA  
4372 C  C   . HIS A 274 ? 0.09690 0.10870 0.12780 -0.00090 0.02090  -0.01540 1733 HIS A C   
4373 O  O   . HIS A 274 ? 0.09520 0.11690 0.14510 -0.01020 0.00270  -0.00730 1733 HIS A O   
4374 C  CB  . HIS A 274 ? 0.08720 0.09550 0.21230 -0.00010 -0.00400 -0.01720 1733 HIS A CB  
4375 C  CG  . HIS A 274 ? 0.09240 0.09160 0.20570 0.00230  -0.00990 -0.01130 1733 HIS A CG  
4376 N  ND1 . HIS A 274 ? 0.10310 0.09950 0.20560 0.00430  0.00910  -0.00260 1733 HIS A ND1 
4377 C  CD2 . HIS A 274 ? 0.09740 0.10420 0.21770 0.01680  -0.00300 -0.00990 1733 HIS A CD2 
4378 C  CE1 . HIS A 274 ? 0.10680 0.10550 0.20850 0.00500  -0.01060 -0.00780 1733 HIS A CE1 
4379 N  NE2 . HIS A 274 ? 0.11000 0.10970 0.22270 0.03030  -0.00740 -0.02680 1733 HIS A NE2 
4387 N  N   . HIS A 275 ? 0.09130 0.09510 0.15530 0.00240  0.00150  -0.00700 1734 HIS A N   
4388 C  CA  . HIS A 275 ? 0.08640 0.10230 0.13090 -0.00730 0.00390  0.00010  1734 HIS A CA  
4389 C  C   . HIS A 275 ? 0.07180 0.10539 0.14350 -0.00530 0.00140  0.00570  1734 HIS A C   
4390 O  O   . HIS A 275 ? 0.09630 0.09520 0.18210 0.00570  -0.01480 -0.01570 1734 HIS A O   
4391 C  CB  . HIS A 275 ? 0.09430 0.10780 0.14560 -0.00210 -0.00260 -0.00390 1734 HIS A CB  
4392 C  CG  . HIS A 275 ? 0.11330 0.11670 0.16010 -0.01950 0.01710  0.00440  1734 HIS A CG  
4393 N  ND1 . HIS A 275 ? 0.10570 0.11030 0.19010 -0.00430 0.02270  0.00500  1734 HIS A ND1 
4394 C  CD2 . HIS A 275 ? 0.14830 0.11760 0.16690 -0.01660 0.02460  -0.00680 1734 HIS A CD2 
4395 C  CE1 . HIS A 275 ? 0.13700 0.11880 0.20010 -0.01450 0.04650  -0.00900 1734 HIS A CE1 
4396 N  NE2 . HIS A 275 ? 0.16140 0.12460 0.18860 -0.03390 0.02500  -0.02570 1734 HIS A NE2 
4404 N  N   . ASN A 276 ? 0.08150 0.09770 0.15170 -0.00500 -0.00750 0.00500  1735 ASN A N   
4405 C  CA  . ASN A 276 ? 0.09410 0.10040 0.16340 0.00350  -0.01330 0.01280  1735 ASN A CA  
4406 C  C   . ASN A 276 ? 0.07990 0.11100 0.14010 0.00940  0.00510  -0.00160 1735 ASN A C   
4407 O  O   . ASN A 276 ? 0.09120 0.10350 0.14330 0.00950  -0.01240 -0.00210 1735 ASN A O   
4408 C  CB  . ASN A 276 ? 0.08060 0.10430 0.17900 -0.00250 -0.01380 0.00360  1735 ASN A CB  
4409 C  CG  . ASN A 276 ? 0.08430 0.10740 0.20120 0.00810  0.01360  0.00180  1735 ASN A CG  
4410 O  OD1 . ASN A 276 ? 0.08350 0.11120 0.23310 0.00600  -0.00470 0.01730  1735 ASN A OD1 
4411 N  ND2 . ASN A 276 ? 0.09340 0.11430 0.17160 0.00800  0.00880  -0.00260 1735 ASN A ND2 
4418 N  N   . PRO A 277 ? 0.08590 0.11450 0.15570 -0.00950 -0.01330 -0.00320 1736 PRO A N   
4419 C  CA  . PRO A 277 ? 0.10560 0.13099 0.17460 -0.01910 -0.01290 0.01030  1736 PRO A CA  
4420 C  C   . PRO A 277 ? 0.11080 0.11680 0.13720 -0.02220 -0.01020 -0.01130 1736 PRO A C   
4421 O  O   . PRO A 277 ? 0.10640 0.11970 0.15780 -0.01230 0.00790  -0.00580 1736 PRO A O   
4422 C  CB  . PRO A 277 ? 0.11440 0.13939 0.17110 -0.02840 0.00330  0.01000  1736 PRO A CB  
4423 C  CG  . PRO A 277 ? 0.10960 0.11220 0.19300 -0.01020 -0.00890 -0.00090 1736 PRO A CG  
4424 C  CD  . PRO A 277 ? 0.08310 0.10410 0.18400 -0.00980 0.00540  0.00300  1736 PRO A CD  
4432 N  N   . ARG A 278 ? 0.12470 0.10550 0.14470 -0.02190 0.00390  -0.01130 1737 ARG A N   
4433 C  CA  . ARG A 278 ? 0.15320 0.10200 0.14540 0.00730  0.00370  0.01100  1737 ARG A CA  
4434 C  C   . ARG A 278 ? 0.13450 0.09930 0.12370 0.02380  0.02910  0.00780  1737 ARG A C   
4435 O  O   . ARG A 278 ? 0.12560 0.11090 0.16230 0.01170  0.01690  0.02570  1737 ARG A O   
4436 C  CB  . ARG A 278 ? 0.17899 0.11630 0.16030 0.02210  0.00690  -0.02430 1737 ARG A CB  
4437 C  CG  . ARG A 278 ? 0.14250 0.12000 0.20590 0.01400  0.02300  -0.02060 1737 ARG A CG  
4438 C  CD  . ARG A 278 ? 0.14980 0.12040 0.24500 -0.00960 0.04580  -0.04950 1737 ARG A CD  
4439 N  NE  . ARG A 278 ? 0.14310 0.14429 0.25330 0.00320  -0.00220 -0.01250 1737 ARG A NE  
4440 C  CZ  . ARG A 278 ? 0.13250 0.15229 0.24780 0.02710  0.01540  -0.01470 1737 ARG A CZ  
4441 N  NH1 . ARG A 278 ? 0.09780 0.14840 0.21800 0.00390  0.01450  0.00790  1737 ARG A NH1 
4442 N  NH2 . ARG A 278 ? 0.13080 0.14280 0.29250 0.01310  0.01360  0.00290  1737 ARG A NH2 
4456 N  N   . ARG A 279 ? 0.09330 0.10540 0.15930 0.02140  0.00850  0.01900  1738 ARG A N   
4457 C  CA  . ARG A 279 ? 0.10310 0.11550 0.12670 0.00460  -0.02320 0.01290  1738 ARG A CA  
4458 C  C   . ARG A 279 ? 0.10120 0.11720 0.12370 0.00060  -0.00070 0.02660  1738 ARG A C   
4459 O  O   . ARG A 279 ? 0.10920 0.12930 0.15120 0.00740  -0.01570 0.01590  1738 ARG A O   
4460 C  CB  . ARG A 279 ? 0.09360 0.12010 0.14860 -0.01120 -0.00280 0.01810  1738 ARG A CB  
4461 C  CG  . ARG A 279 ? 0.08870 0.14300 0.14810 -0.00880 0.00200  0.03270  1738 ARG A CG  
4462 C  CD  . ARG A 279 ? 0.10380 0.16829 0.21530 -0.01410 0.02290  0.04240  1738 ARG A CD  
4463 N  NE  . ARG A 279 ? 0.11390 0.17690 0.24490 -0.01040 -0.02210 0.08430  1738 ARG A NE  
4464 C  CZ  . ARG A 279 ? 0.21239 0.17100 0.31290 -0.01370 -0.03860 0.08820  1738 ARG A CZ  
4465 N  NH1 . ARG A 279 ? 0.19330 0.14970 0.31590 -0.02500 -0.03460 0.07530  1738 ARG A NH1 
4466 N  NH2 . ARG A 279 ? 0.25560 0.18390 0.39340 -0.01900 -0.05950 0.10130  1738 ARG A NH2 
4480 N  N   . ILE A 280 ? 0.07430 0.10140 0.17060 0.00350  -0.00580 0.01440  1739 ILE A N   
4481 C  CA  . ILE A 280 ? 0.09120 0.11719 0.17000 0.01710  -0.01340 0.00890  1739 ILE A CA  
4482 C  C   . ILE A 280 ? 0.11700 0.12150 0.16660 0.00540  0.01150  -0.00970 1739 ILE A C   
4483 O  O   . ILE A 280 ? 0.13600 0.13240 0.19110 -0.00510 0.00260  -0.00460 1739 ILE A O   
4484 C  CB  . ILE A 280 ? 0.11790 0.10910 0.15840 -0.00100 -0.02200 -0.00230 1739 ILE A CB  
4485 C  CG1 . ILE A 280 ? 0.14100 0.11770 0.14180 -0.00490 -0.01410 -0.00780 1739 ILE A CG1 
4486 C  CG2 . ILE A 280 ? 0.14770 0.12579 0.18540 0.00780  -0.01650 -0.01660 1739 ILE A CG2 
4487 C  CD1 . ILE A 280 ? 0.15460 0.11720 0.19490 0.02980  -0.01840 -0.01900 1739 ILE A CD1 
4499 N  N   . PHE A 281 ? 0.11380 0.10540 0.17250 0.00330  0.01380  0.00200  1740 PHE A N   
4500 C  CA  . PHE A 281 ? 0.12260 0.11180 0.16750 0.01200  0.01080  -0.00620 1740 PHE A CA  
4501 C  C   . PHE A 281 ? 0.13330 0.12280 0.16650 0.00680  -0.00330 0.00890  1740 PHE A C   
4502 O  O   . PHE A 281 ? 0.12750 0.13720 0.19010 0.01360  0.02470  0.02440  1740 PHE A O   
4503 C  CB  . PHE A 281 ? 0.13020 0.10240 0.16140 0.01710  0.03440  -0.00670 1740 PHE A CB  
4504 C  CG  . PHE A 281 ? 0.12300 0.10030 0.12780 0.00560  0.02060  -0.01420 1740 PHE A CG  
4505 C  CD1 . PHE A 281 ? 0.13410 0.11640 0.14630 0.02060  0.02760  -0.00430 1740 PHE A CD1 
4506 C  CD2 . PHE A 281 ? 0.12600 0.10990 0.14230 -0.00330 0.00310  -0.01420 1740 PHE A CD2 
4507 C  CE1 . PHE A 281 ? 0.14510 0.13410 0.17870 0.02710  0.04460  0.00160  1740 PHE A CE1 
4508 C  CE2 . PHE A 281 ? 0.11410 0.12430 0.13450 -0.00170 -0.01260 -0.00490 1740 PHE A CE2 
4509 C  CZ  . PHE A 281 ? 0.15909 0.13969 0.13050 0.02310  -0.00650 -0.00410 1740 PHE A CZ  
4519 N  N   A HIS A 282 ? 0.10920 0.11790 0.16220 0.00130  0.01770  0.01660  1741 HIS A N   
4520 N  N   B HIS A 282 ? 0.12790 0.12270 0.16040 -0.00090 0.01520  0.02440  1741 HIS A N   
4521 C  CA  A HIS A 282 ? 0.09930 0.12620 0.16910 0.02350  0.00230  0.02080  1741 HIS A CA  
4522 C  CA  B HIS A 282 ? 0.12630 0.12810 0.17140 0.00850  0.00580  0.02810  1741 HIS A CA  
4523 C  C   A HIS A 282 ? 0.10170 0.13410 0.15200 0.01550  0.02590  0.04160  1741 HIS A C   
4524 C  C   B HIS A 282 ? 0.11940 0.13250 0.16130 0.00870  0.02050  0.04030  1741 HIS A C   
4525 O  O   A HIS A 282 ? 0.12620 0.14450 0.19500 0.01100  0.01080  0.05530  1741 HIS A O   
4526 O  O   B HIS A 282 ? 0.13690 0.13870 0.18750 0.00840  0.01460  0.04830  1741 HIS A O   
4527 C  CB  A HIS A 282 ? 0.12750 0.13639 0.17070 0.02640  0.00100  0.02150  1741 HIS A CB  
4528 C  CB  B HIS A 282 ? 0.14260 0.13460 0.17920 0.00210  -0.00160 0.03620  1741 HIS A CB  
4529 C  CG  A HIS A 282 ? 0.11920 0.12920 0.14800 0.00620  0.03970  0.01290  1741 HIS A CG  
4530 C  CG  B HIS A 282 ? 0.14690 0.13420 0.16560 -0.01490 0.00190  0.03350  1741 HIS A CG  
4531 N  ND1 A HIS A 282 ? 0.18809 0.13460 0.16650 -0.02890 -0.03080 0.01580  1741 HIS A ND1 
4532 N  ND1 B HIS A 282 ? 0.15780 0.14489 0.19130 -0.01610 0.02460  0.01900  1741 HIS A ND1 
4533 C  CD2 A HIS A 282 ? 0.15780 0.13600 0.15590 -0.00220 0.06130  0.00250  1741 HIS A CD2 
4534 C  CD2 B HIS A 282 ? 0.16010 0.12870 0.18590 -0.03250 -0.01130 0.02620  1741 HIS A CD2 
4535 C  CE1 A HIS A 282 ? 0.16760 0.13910 0.16400 -0.04070 -0.00810 0.02480  1741 HIS A CE1 
4536 C  CE1 B HIS A 282 ? 0.16690 0.13700 0.20340 -0.02330 0.01550  0.00090  1741 HIS A CE1 
4537 N  NE2 A HIS A 282 ? 0.19269 0.13710 0.18390 -0.00100 0.02220  0.01050  1741 HIS A NE2 
4538 N  NE2 B HIS A 282 ? 0.15150 0.12620 0.20940 -0.02440 -0.01140 -0.00010 1741 HIS A NE2 
4552 N  N   . LEU A 283 ? 0.10230 0.12360 0.17240 0.00860  0.01950  0.04150  1742 LEU A N   
4553 C  CA  . LEU A 283 ? 0.10320 0.11920 0.19330 -0.01920 0.01750  0.01670  1742 LEU A CA  
4554 C  C   . LEU A 283 ? 0.12180 0.11930 0.22180 -0.01820 0.01130  0.01580  1742 LEU A C   
4555 O  O   . LEU A 283 ? 0.14630 0.12960 0.24990 -0.01020 0.06060  0.00780  1742 LEU A O   
4556 C  CB  . LEU A 283 ? 0.12290 0.12080 0.21220 -0.01510 0.04580  0.00490  1742 LEU A CB  
4557 C  CG  . LEU A 283 ? 0.11800 0.12320 0.19830 -0.00940 0.01800  -0.00210 1742 LEU A CG  
4558 C  CD1 . LEU A 283 ? 0.10540 0.12930 0.21770 -0.00480 -0.00400 0.03250  1742 LEU A CD1 
4559 C  CD2 . LEU A 283 ? 0.11750 0.12860 0.19000 0.00020  0.02980  -0.00520 1742 LEU A CD2 
4571 N  N   . PRO A 284 ? 0.11000 0.11920 0.20110 -0.00330 0.00870  0.00600  1743 PRO A N   
4572 C  CA  . PRO A 284 ? 0.10970 0.11430 0.19250 -0.00670 0.00920  -0.01530 1743 PRO A CA  
4573 C  C   . PRO A 284 ? 0.10680 0.11860 0.19000 -0.00820 0.02100  -0.02070 1743 PRO A C   
4574 O  O   . PRO A 284 ? 0.09200 0.13569 0.21380 -0.00080 0.01100  -0.01000 1743 PRO A O   
4575 C  CB  . PRO A 284 ? 0.13850 0.12350 0.19470 0.01850  -0.00890 -0.02470 1743 PRO A CB  
4576 C  CG  . PRO A 284 ? 0.15200 0.12700 0.19640 0.01830  0.02060  0.00410  1743 PRO A CG  
4577 C  CD  . PRO A 284 ? 0.12640 0.12640 0.21180 0.00310  0.00340  0.01340  1743 PRO A CD  
4585 N  N   . PRO A 285 ? 0.09340 0.12390 0.19980 0.00290  0.02580  -0.02630 1744 PRO A N   
4586 C  CA  . PRO A 285 ? 0.09780 0.11090 0.20630 -0.00290 0.03460  -0.01730 1744 PRO A CA  
4587 C  C   . PRO A 285 ? 0.11070 0.10740 0.22480 0.00460  0.00080  -0.00530 1744 PRO A C   
4588 O  O   . PRO A 285 ? 0.11550 0.11760 0.23980 -0.00700 0.00270  -0.00200 1744 PRO A O   
4589 C  CB  . PRO A 285 ? 0.11460 0.13440 0.23780 -0.00080 0.03650  -0.01850 1744 PRO A CB  
4590 C  CG  . PRO A 285 ? 0.10760 0.16479 0.26030 -0.00100 0.01280  -0.03790 1744 PRO A CG  
4591 C  CD  . PRO A 285 ? 0.09390 0.14760 0.21390 0.00190  0.02000  -0.02890 1744 PRO A CD  
4599 N  N   . GLN A 286 ? 0.10810 0.10090 0.24110 0.00310  -0.00040 -0.01300 1745 GLN A N   
4600 C  CA  . GLN A 286 ? 0.12500 0.11750 0.21420 -0.00360 0.00340  -0.02200 1745 GLN A CA  
4601 C  C   . GLN A 286 ? 0.12980 0.11820 0.23150 -0.00040 -0.01420 -0.02620 1745 GLN A C   
4602 O  O   . GLN A 286 ? 0.15380 0.12370 0.23720 0.01360  0.00890  -0.03930 1745 GLN A O   
4603 C  CB  . GLN A 286 ? 0.11700 0.12089 0.22660 -0.01300 -0.00330 -0.00740 1745 GLN A CB  
4604 C  CG  . GLN A 286 ? 0.14470 0.10630 0.21430 -0.01190 -0.00320 -0.01490 1745 GLN A CG  
4605 C  CD  . GLN A 286 ? 0.12030 0.09730 0.22240 -0.02490 0.00230  -0.00840 1745 GLN A CD  
4606 O  OE1 . GLN A 286 ? 0.11610 0.10270 0.20570 -0.02080 0.00410  0.00140  1745 GLN A OE1 
4607 N  NE2 . GLN A 286 ? 0.12380 0.10060 0.20770 -0.00340 -0.00270 0.01520  1745 GLN A NE2 
4616 N  N   A GLU A 287 ? 0.14030 0.12980 0.22760 0.01010  0.00070  -0.01600 1746 GLU A N   
4617 N  N   B GLU A 287 ? 0.12810 0.11910 0.22760 0.01700  0.00430  -0.02080 1746 GLU A N   
4618 C  CA  A GLU A 287 ? 0.17730 0.15050 0.23430 0.01440  0.00330  -0.03040 1746 GLU A CA  
4619 C  CA  B GLU A 287 ? 0.16120 0.13140 0.22810 0.02410  0.00570  -0.04890 1746 GLU A CA  
4620 C  C   A GLU A 287 ? 0.16200 0.12630 0.22440 0.01140  0.00400  -0.02340 1746 GLU A C   
4621 C  C   B GLU A 287 ? 0.14940 0.11290 0.22180 0.01460  0.00550  -0.03150 1746 GLU A C   
4622 O  O   A GLU A 287 ? 0.14370 0.11850 0.25290 -0.00380 0.01140  -0.00230 1746 GLU A O   
4623 O  O   B GLU A 287 ? 0.12610 0.10110 0.26280 -0.00710 0.01690  0.00060  1746 GLU A O   
4624 C  CB  A GLU A 287 ? 0.22150 0.19200 0.27410 0.03360  -0.00140 -0.03280 1746 GLU A CB  
4625 C  CB  B GLU A 287 ? 0.19450 0.15920 0.26270 0.04980  0.00280  -0.06870 1746 GLU A CB  
4626 C  CG  A GLU A 287 ? 0.27450 0.22870 0.31240 0.03350  0.01190  -0.00930 1746 GLU A CG  
4627 C  CG  B GLU A 287 ? 0.24470 0.18360 0.29220 0.03510  0.00190  -0.04870 1746 GLU A CG  
4628 C  CD  A GLU A 287 ? 0.31490 0.26810 0.36550 0.03200  0.02490  0.01090  1746 GLU A CD  
4629 C  CD  B GLU A 287 ? 0.31860 0.20450 0.32540 0.01420  0.02280  -0.01020 1746 GLU A CD  
4630 O  OE1 A GLU A 287 ? 0.34120 0.28459 0.38850 0.02380  -0.01120 0.02110  1746 GLU A OE1 
4631 O  OE1 B GLU A 287 ? 0.37150 0.21360 0.35990 0.01360  0.05450  0.00990  1746 GLU A OE1 
4632 O  OE2 A GLU A 287 ? 0.31050 0.27810 0.37550 0.04760  0.05290  0.02030  1746 GLU A OE2 
4633 O  OE2 B GLU A 287 ? 0.29760 0.20780 0.32320 -0.00690 0.00590  0.01290  1746 GLU A OE2 
4646 N  N   . ASP A 288 ? 0.15820 0.12050 0.23040 0.01020  0.00940  -0.02000 1747 ASP A N   
4647 C  CA  A ASP A 288 ? 0.16180 0.13270 0.23630 0.01950  0.01770  -0.03420 1747 ASP A CA  
4648 C  CA  B ASP A 288 ? 0.16030 0.13860 0.23510 0.02000  0.01540  -0.02520 1747 ASP A CA  
4649 C  C   . ASP A 288 ? 0.14460 0.13300 0.25060 0.00950  0.02400  -0.02210 1747 ASP A C   
4650 O  O   . ASP A 288 ? 0.15200 0.12770 0.26080 0.01140  0.02050  -0.04710 1747 ASP A O   
4651 C  CB  A ASP A 288 ? 0.16410 0.14590 0.25750 0.01100  -0.00750 -0.05340 1747 ASP A CB  
4652 C  CB  B ASP A 288 ? 0.16230 0.16090 0.24650 0.02040  -0.01140 -0.02540 1747 ASP A CB  
4653 C  CG  A ASP A 288 ? 0.19170 0.15710 0.27230 -0.01030 0.00110  -0.05920 1747 ASP A CG  
4654 C  CG  B ASP A 288 ? 0.18800 0.18320 0.24640 0.02190  0.00330  -0.02090 1747 ASP A CG  
4655 O  OD1 A ASP A 288 ? 0.23200 0.15340 0.29320 -0.01140 -0.02770 -0.07000 1747 ASP A OD1 
4656 O  OD1 B ASP A 288 ? 0.18520 0.19100 0.23210 0.02820  0.04780  -0.01730 1747 ASP A OD1 
4657 O  OD2 A ASP A 288 ? 0.20600 0.15950 0.30040 -0.02230 0.00340  -0.06200 1747 ASP A OD2 
4658 O  OD2 B ASP A 288 ? 0.17650 0.19580 0.30280 0.04240  -0.00850 -0.00760 1747 ASP A OD2 
4667 N  N   . THR A 289 ? 0.12160 0.13110 0.23890 -0.00210 0.02940  -0.00300 1748 THR A N   
4668 C  CA  . THR A 289 ? 0.13340 0.13779 0.22840 -0.00990 0.01500  0.00580  1748 THR A CA  
4669 C  C   . THR A 289 ? 0.13300 0.14250 0.19910 -0.01530 0.01280  -0.01690 1748 THR A C   
4670 O  O   . THR A 289 ? 0.14050 0.14290 0.25640 -0.01650 0.01300  -0.00610 1748 THR A O   
4671 C  CB  . THR A 289 ? 0.11960 0.11730 0.24820 0.00320  0.01350  -0.00290 1748 THR A CB  
4672 O  OG1 . THR A 289 ? 0.12430 0.10740 0.21900 0.00700  0.01720  -0.01420 1748 THR A OG1 
4673 C  CG2 . THR A 289 ? 0.13040 0.11060 0.23100 -0.00030 0.00150  -0.00060 1748 THR A CG2 
4681 N  N   . TYR A 290 ? 0.13750 0.13410 0.19840 -0.00420 0.02930  -0.04070 1749 TYR A N   
4682 C  CA  . TYR A 290 ? 0.13130 0.13480 0.23850 -0.01730 0.03310  -0.01310 1749 TYR A CA  
4683 C  C   . TYR A 290 ? 0.14180 0.12430 0.21610 -0.03180 0.03190  -0.02010 1749 TYR A C   
4684 O  O   . TYR A 290 ? 0.16920 0.12590 0.20970 -0.04190 0.01590  -0.01010 1749 TYR A O   
4685 C  CB  . TYR A 290 ? 0.18300 0.14140 0.23620 -0.01680 0.03390  -0.01320 1749 TYR A CB  
4686 C  CG  . TYR A 290 ? 0.20450 0.16700 0.26190 -0.00770 0.08940  -0.03980 1749 TYR A CG  
4687 C  CD1 . TYR A 290 ? 0.21330 0.16810 0.33010 0.02070  0.09240  -0.03590 1749 TYR A CD1 
4688 C  CD2 . TYR A 290 ? 0.23920 0.18790 0.26390 -0.02390 0.07370  -0.06070 1749 TYR A CD2 
4689 C  CE1 . TYR A 290 ? 0.26310 0.17440 0.32270 0.00840  0.09530  -0.04560 1749 TYR A CE1 
4690 C  CE2 . TYR A 290 ? 0.27270 0.19939 0.27740 -0.04280 0.08900  -0.06330 1749 TYR A CE2 
4691 C  CZ  . TYR A 290 ? 0.28730 0.18240 0.29880 -0.02160 0.11370  -0.08600 1749 TYR A CZ  
4692 O  OH  . TYR A 290 ? 0.34350 0.20229 0.41329 -0.02950 0.12360  -0.09310 1749 TYR A OH  
4702 N  N   . VAL A 291 ? 0.13610 0.13430 0.19410 -0.02300 0.01890  -0.02030 1750 VAL A N   
4703 C  CA  . VAL A 291 ? 0.13060 0.14480 0.21210 -0.02200 0.00670  -0.02000 1750 VAL A CA  
4704 C  C   . VAL A 291 ? 0.14820 0.15860 0.21000 -0.03690 0.01410  -0.05020 1750 VAL A C   
4705 O  O   . VAL A 291 ? 0.16850 0.19499 0.24530 -0.07510 -0.01540 0.00460  1750 VAL A O   
4706 C  CB  . VAL A 291 ? 0.13900 0.15480 0.22870 -0.01930 0.00930  -0.02420 1750 VAL A CB  
4707 C  CG1 . VAL A 291 ? 0.15030 0.16440 0.24510 -0.00310 0.03510  0.00290  1750 VAL A CG1 
4708 C  CG2 . VAL A 291 ? 0.13080 0.14350 0.26230 -0.02620 -0.00010 -0.05380 1750 VAL A CG2 
4718 N  N   . GLU A 292 ? 0.15020 0.15310 0.20550 -0.03270 0.03250  -0.07240 1751 GLU A N   
4719 C  CA  . GLU A 292 ? 0.15510 0.16780 0.21910 -0.02040 0.02530  -0.06260 1751 GLU A CA  
4720 C  C   . GLU A 292 ? 0.13410 0.15860 0.20550 -0.02630 0.01710  -0.03380 1751 GLU A C   
4721 O  O   . GLU A 292 ? 0.14530 0.14840 0.21620 -0.02550 0.02750  -0.04050 1751 GLU A O   
4722 C  CB  . GLU A 292 ? 0.16890 0.18760 0.21540 -0.00870 0.01240  -0.09550 1751 GLU A CB  
4723 C  CG  . GLU A 292 ? 0.19430 0.22020 0.28450 -0.00850 0.00530  -0.11390 1751 GLU A CG  
4724 C  CD  . GLU A 292 ? 0.22780 0.25940 0.33160 0.00810  -0.00410 -0.12190 1751 GLU A CD  
4725 O  OE1 . GLU A 292 ? 0.27640 0.27040 0.39180 -0.01290 0.00980  -0.09550 1751 GLU A OE1 
4726 O  OE2 . GLU A 292 ? 0.26780 0.28909 0.40080 0.00080  0.00460  -0.10490 1751 GLU A OE2 
4733 N  N   . VAL A 293 ? 0.14730 0.15900 0.20460 -0.02540 0.01380  -0.01580 1752 VAL A N   
4734 C  CA  . VAL A 293 ? 0.16230 0.16450 0.17010 -0.02330 -0.00250 -0.03240 1752 VAL A CA  
4735 C  C   . VAL A 293 ? 0.16330 0.17280 0.17110 -0.02190 0.05110  -0.04130 1752 VAL A C   
4736 O  O   . VAL A 293 ? 0.16950 0.18420 0.20430 -0.02310 0.03470  -0.03670 1752 VAL A O   
4737 C  CB  . VAL A 293 ? 0.18450 0.16550 0.22330 -0.03520 -0.01500 -0.03340 1752 VAL A CB  
4738 C  CG1 . VAL A 293 ? 0.18190 0.16080 0.25350 -0.02480 -0.00610 -0.02880 1752 VAL A CG1 
4739 C  CG2 . VAL A 293 ? 0.22810 0.17880 0.21660 -0.03180 0.00420  -0.02440 1752 VAL A CG2 
4749 N  N   . ASP A 294 ? 0.16640 0.19840 0.20330 -0.01460 0.01570  -0.03470 1753 ASP A N   
4750 C  CA  . ASP A 294 ? 0.17700 0.21970 0.20940 -0.00960 0.01800  -0.05930 1753 ASP A CA  
4751 C  C   . ASP A 294 ? 0.20480 0.22390 0.18520 -0.00080 0.01110  -0.04470 1753 ASP A C   
4752 O  O   . ASP A 294 ? 0.22150 0.21100 0.19790 -0.01440 0.02600  -0.03960 1753 ASP A O   
4753 C  CB  . ASP A 294 ? 0.21370 0.25300 0.26300 -0.03620 -0.01040 -0.08270 1753 ASP A CB  
4754 C  CG  . ASP A 294 ? 0.26880 0.29420 0.29170 -0.04070 -0.03340 -0.09800 1753 ASP A CG  
4755 O  OD1 . ASP A 294 ? 0.30260 0.30950 0.25640 -0.00060 -0.04110 -0.05600 1753 ASP A OD1 
4756 O  OD2 . ASP A 294 ? 0.31150 0.33049 0.34770 -0.06400 -0.06060 -0.11880 1753 ASP A OD2 
4761 N  N   . LEU A 295 ? 0.24030 0.24030 0.21440 0.00650  0.04210  -0.04810 1754 LEU A N   
4762 C  CA  . LEU A 295 ? 0.25540 0.25650 0.22440 -0.00890 0.04560  -0.03180 1754 LEU A CA  
4763 C  C   . LEU A 295 ? 0.24260 0.28630 0.24930 0.00640  0.04930  -0.01720 1754 LEU A C   
4764 O  O   . LEU A 295 ? 0.25420 0.28700 0.30160 0.01570  0.02350  -0.00480 1754 LEU A O   
4765 C  CB  . LEU A 295 ? 0.28640 0.25300 0.25000 -0.02740 0.03190  -0.02870 1754 LEU A CB  
4766 C  CG  . LEU A 295 ? 0.30620 0.25900 0.25110 -0.02740 0.02500  -0.01300 1754 LEU A CG  
4767 C  CD1 . LEU A 295 ? 0.32780 0.26790 0.30170 -0.04420 0.00440  -0.01140 1754 LEU A CD1 
4768 C  CD2 . LEU A 295 ? 0.35430 0.26160 0.25880 -0.01340 -0.02690 -0.02340 1754 LEU A CD2 
4780 N  N   . GLU A 296 ? 0.26570 0.31460 0.19550 0.02390  0.06010  0.00260  1755 GLU A N   
4781 C  CA  . GLU A 296 ? 0.28320 0.34690 0.29570 0.02310  0.01050  -0.00470 1755 GLU A CA  
4782 C  C   . GLU A 296 ? 0.26990 0.34180 0.29370 0.01440  0.02510  -0.03350 1755 GLU A C   
4783 O  O   . GLU A 296 ? 0.29270 0.35720 0.35260 0.00530  0.00340  -0.02510 1755 GLU A O   
4784 C  CB  . GLU A 296 ? 0.33240 0.38290 0.35930 0.01870  -0.00510 -0.00210 1755 GLU A CB  
4785 C  CG  . GLU A 296 ? 0.42050 0.41570 0.44450 0.00150  -0.00920 0.00250  1755 GLU A CG  
4786 C  CD  . GLU A 296 ? 0.48780 0.44610 0.51270 -0.01070 -0.02860 0.01870  1755 GLU A CD  
4787 O  OE1 . GLU A 296 ? 0.51340 0.45670 0.54760 -0.01480 -0.03200 0.02470  1755 GLU A OE1 
4788 O  OE2 . GLU A 296 ? 0.51090 0.45890 0.53520 -0.01560 -0.02790 0.02930  1755 GLU A OE2 
4795 N  N   . HIS A 297 ? 0.26080 0.32620 0.29910 -0.00680 0.03070  -0.07170 1756 HIS A N   
4796 C  CA  . HIS A 297 ? 0.25990 0.32960 0.29860 -0.02470 0.02050  -0.06990 1756 HIS A CA  
4797 C  C   . HIS A 297 ? 0.23340 0.32190 0.26050 -0.02780 0.01000  -0.08290 1756 HIS A C   
4798 O  O   . HIS A 297 ? 0.19730 0.30780 0.26550 -0.00730 -0.00440 -0.08380 1756 HIS A O   
4799 C  CB  . HIS A 297 ? 0.28360 0.33810 0.28540 -0.05220 -0.00820 -0.09020 1756 HIS A CB  
4800 C  CG  . HIS A 297 ? 0.31200 0.35880 0.33200 -0.07270 -0.01820 -0.06300 1756 HIS A CG  
4801 N  ND1 . HIS A 297 ? 0.33370 0.36710 0.36660 -0.07990 -0.01580 -0.06090 1756 HIS A ND1 
4802 C  CD2 . HIS A 297 ? 0.33050 0.36540 0.34980 -0.07990 -0.01990 -0.06120 1756 HIS A CD2 
4803 C  CE1 . HIS A 297 ? 0.32950 0.36560 0.36360 -0.08280 -0.00700 -0.05190 1756 HIS A CE1 
4804 N  NE2 . HIS A 297 ? 0.32750 0.36840 0.37320 -0.07970 -0.00620 -0.03330 1756 HIS A NE2 
4812 N  N   . GLU A 298 ? 0.22840 0.32810 0.19960 -0.02800 0.01110  -0.08370 1757 GLU A N   
4813 C  CA  . GLU A 298 ? 0.22360 0.33060 0.22080 -0.03510 -0.02160 -0.06160 1757 GLU A CA  
4814 C  C   . GLU A 298 ? 0.19800 0.31340 0.16370 -0.03090 -0.00080 -0.08170 1757 GLU A C   
4815 O  O   . GLU A 298 ? 0.21120 0.32300 0.22560 -0.05290 0.00780  -0.09560 1757 GLU A O   
4816 C  CB  . GLU A 298 ? 0.28220 0.35410 0.27100 -0.05340 -0.02140 -0.02380 1757 GLU A CB  
4817 C  CG  . GLU A 298 ? 0.39320 0.38100 0.31600 -0.05320 -0.01610 -0.00460 1757 GLU A CG  
4818 C  CD  . GLU A 298 ? 0.49910 0.40870 0.38460 -0.06250 -0.03540 0.01390  1757 GLU A CD  
4819 O  OE1 . GLU A 298 ? 0.53920 0.42400 0.41890 -0.06190 -0.03580 0.02480  1757 GLU A OE1 
4820 O  OE2 . GLU A 298 ? 0.54210 0.42220 0.42430 -0.05910 -0.03220 0.03070  1757 GLU A OE2 
4827 N  N   . TRP A 299 ? 0.16800 0.29190 0.15820 -0.01430 -0.02050 -0.05580 1758 TRP A N   
4828 C  CA  . TRP A 299 ? 0.16390 0.27340 0.17860 -0.02300 -0.02050 -0.04380 1758 TRP A CA  
4829 C  C   . TRP A 299 ? 0.15830 0.27270 0.20020 -0.02210 -0.01130 -0.04700 1758 TRP A C   
4830 O  O   . TRP A 299 ? 0.17600 0.27060 0.23760 -0.01850 -0.01020 -0.05020 1758 TRP A O   
4831 C  CB  . TRP A 299 ? 0.17320 0.25980 0.19400 -0.03230 -0.03940 -0.04620 1758 TRP A CB  
4832 C  CG  . TRP A 299 ? 0.15780 0.24460 0.18980 -0.02620 -0.01000 -0.03620 1758 TRP A CG  
4833 C  CD1 . TRP A 299 ? 0.18210 0.24600 0.19060 -0.01580 -0.03270 -0.03110 1758 TRP A CD1 
4834 C  CD2 . TRP A 299 ? 0.16570 0.23710 0.17200 -0.03690 -0.01930 -0.02350 1758 TRP A CD2 
4835 N  NE1 . TRP A 299 ? 0.18540 0.24520 0.20090 -0.02120 -0.02250 -0.00400 1758 TRP A NE1 
4836 C  CE2 . TRP A 299 ? 0.16520 0.23590 0.17910 -0.03700 -0.01070 -0.00100 1758 TRP A CE2 
4837 C  CE3 . TRP A 299 ? 0.16090 0.25090 0.17430 -0.04000 -0.00060 0.00980  1758 TRP A CE3 
4838 C  CZ2 . TRP A 299 ? 0.16010 0.23830 0.16700 -0.06150 0.00600  0.01540  1758 TRP A CZ2 
4839 C  CZ3 . TRP A 299 ? 0.14870 0.25650 0.21130 -0.05700 -0.00260 0.02560  1758 TRP A CZ3 
4840 C  CH2 . TRP A 299 ? 0.17510 0.24930 0.20070 -0.05580 -0.01420 0.02830  1758 TRP A CH2 
4851 N  N   . THR A 300 ? 0.16670 0.27580 0.15130 -0.02680 -0.01260 -0.05300 1759 THR A N   
4852 C  CA  . THR A 300 ? 0.17620 0.28220 0.13750 -0.01730 -0.03250 -0.03150 1759 THR A CA  
4853 C  C   . THR A 300 ? 0.18320 0.26800 0.12730 -0.01650 -0.02820 -0.03460 1759 THR A C   
4854 O  O   . THR A 300 ? 0.17100 0.26690 0.17340 -0.03780 -0.02120 -0.03130 1759 THR A O   
4855 C  CB  . THR A 300 ? 0.19580 0.29730 0.15880 -0.01260 -0.04090 -0.02180 1759 THR A CB  
4856 O  OG1 . THR A 300 ? 0.23350 0.30780 0.19300 0.01920  -0.03440 -0.02040 1759 THR A OG1 
4857 C  CG2 . THR A 300 ? 0.22400 0.30410 0.20120 -0.01500 -0.02190 -0.01110 1759 THR A CG2 
4865 N  N   . ILE A 301 ? 0.16370 0.24980 0.12060 0.00090  -0.02400 -0.03640 1760 ILE A N   
4866 C  CA  A ILE A 301 ? 0.15120 0.24300 0.11220 0.00670  -0.03030 -0.03720 1760 ILE A CA  
4867 C  CA  B ILE A 301 ? 0.16070 0.23880 0.14780 0.00220  -0.02640 -0.03180 1760 ILE A CA  
4868 C  C   . ILE A 301 ? 0.13900 0.23770 0.17410 0.00260  -0.03530 -0.03020 1760 ILE A C   
4869 O  O   . ILE A 301 ? 0.12960 0.23120 0.20760 0.00400  -0.03290 -0.05370 1760 ILE A O   
4870 C  CB  A ILE A 301 ? 0.12840 0.24150 0.11840 -0.00290 -0.05230 -0.03140 1760 ILE A CB  
4871 C  CB  B ILE A 301 ? 0.17010 0.23100 0.16200 -0.00190 -0.02070 -0.02830 1760 ILE A CB  
4872 C  CG1 A ILE A 301 ? 0.12650 0.23430 0.17670 -0.00910 -0.01770 -0.00270 1760 ILE A CG1 
4873 C  CG1 B ILE A 301 ? 0.17290 0.22500 0.18240 -0.00480 -0.01110 -0.01740 1760 ILE A CG1 
4874 C  CG2 A ILE A 301 ? 0.11530 0.24350 0.15270 -0.01460 -0.03460 -0.02560 1760 ILE A CG2 
4875 C  CG2 B ILE A 301 ? 0.16820 0.22940 0.17270 -0.00400 -0.01170 -0.02280 1760 ILE A CG2 
4876 C  CD1 A ILE A 301 ? 0.12910 0.23360 0.15580 -0.00690 -0.00560 -0.00060 1760 ILE A CD1 
4877 C  CD1 B ILE A 301 ? 0.17170 0.22080 0.16570 -0.00050 -0.00500 -0.01740 1760 ILE A CD1 
4900 N  N   . PRO A 302 ? 0.13110 0.23480 0.18710 -0.00420 -0.03240 -0.03030 1761 PRO A N   
4901 C  CA  . PRO A 302 ? 0.12760 0.24060 0.21270 -0.03180 -0.02860 -0.04190 1761 PRO A CA  
4902 C  C   . PRO A 302 ? 0.12370 0.23730 0.19750 -0.02810 -0.01590 -0.03720 1761 PRO A C   
4903 O  O   . PRO A 302 ? 0.12240 0.23920 0.22230 -0.01230 -0.01630 -0.04780 1761 PRO A O   
4904 C  CB  . PRO A 302 ? 0.14330 0.25029 0.23000 -0.02560 0.00980  -0.05050 1761 PRO A CB  
4905 C  CG  . PRO A 302 ? 0.17370 0.24460 0.22530 -0.02710 0.00820  -0.05310 1761 PRO A CG  
4906 C  CD  . PRO A 302 ? 0.18719 0.23980 0.20910 -0.01290 -0.03030 -0.04080 1761 PRO A CD  
4914 N  N   . SER A 303 ? 0.13280 0.23940 0.18420 -0.02630 -0.02420 -0.00940 1762 SER A N   
4915 C  CA  . SER A 303 ? 0.12110 0.25660 0.19730 -0.00850 -0.00380 -0.00060 1762 SER A CA  
4916 C  C   . SER A 303 ? 0.11210 0.24880 0.18980 -0.01120 -0.00970 -0.00740 1762 SER A C   
4917 O  O   . SER A 303 ? 0.13300 0.24700 0.20340 -0.00030 -0.02420 0.00050  1762 SER A O   
4918 C  CB  . SER A 303 ? 0.13080 0.28420 0.24400 0.00080  -0.02450 -0.00630 1762 SER A CB  
4919 O  OG  . SER A 303 ? 0.16090 0.30229 0.27910 -0.02470 -0.02720 -0.03220 1762 SER A OG  
4925 N  N   . HIS A 304 ? 0.10740 0.24050 0.17270 -0.01330 -0.03370 -0.02650 1763 HIS A N   
4926 C  CA  . HIS A 304 ? 0.11580 0.22300 0.20910 -0.01690 -0.01900 -0.02640 1763 HIS A CA  
4927 C  C   . HIS A 304 ? 0.13110 0.22050 0.16660 -0.01600 -0.00800 -0.04100 1763 HIS A C   
4928 O  O   . HIS A 304 ? 0.14640 0.22780 0.18890 -0.01840 -0.01410 -0.05480 1763 HIS A O   
4929 C  CB  . HIS A 304 ? 0.15230 0.21270 0.20320 -0.02070 -0.00260 -0.03780 1763 HIS A CB  
4930 C  CG  . HIS A 304 ? 0.15910 0.22320 0.24920 -0.02340 -0.00860 -0.02080 1763 HIS A CG  
4931 N  ND1 . HIS A 304 ? 0.17980 0.23549 0.25450 -0.02380 -0.00120 -0.03760 1763 HIS A ND1 
4932 C  CD2 . HIS A 304 ? 0.19320 0.22410 0.27380 -0.03560 0.02370  -0.01000 1763 HIS A CD2 
4933 C  CE1 . HIS A 304 ? 0.20190 0.23210 0.28700 -0.02050 -0.01240 -0.02950 1763 HIS A CE1 
4934 N  NE2 . HIS A 304 ? 0.22450 0.23260 0.32550 -0.02520 0.00520  -0.02360 1763 HIS A NE2 
4942 N  N   . MET A 305 ? 0.12690 0.20810 0.18960 -0.01810 -0.02640 -0.03300 1764 MET A N   
4943 C  CA  . MET A 305 ? 0.12750 0.19700 0.19540 -0.03980 -0.00830 -0.02280 1764 MET A CA  
4944 C  C   . MET A 305 ? 0.11570 0.19690 0.21220 -0.02420 -0.00790 -0.02900 1764 MET A C   
4945 O  O   . MET A 305 ? 0.12810 0.19280 0.20650 -0.01580 -0.01890 -0.02110 1764 MET A O   
4946 C  CB  . MET A 305 ? 0.11490 0.19280 0.19210 -0.03330 -0.01120 -0.00940 1764 MET A CB  
4947 C  CG  . MET A 305 ? 0.13800 0.22170 0.26360 -0.04510 -0.00500 0.00800  1764 MET A CG  
4948 S  SD  . MET A 305 ? 0.17719 0.26329 0.26380 -0.06400 -0.06100 0.05200  1764 MET A SD  
4949 C  CE  . MET A 305 ? 0.16290 0.28919 0.22660 -0.04640 -0.04090 0.01870  1764 MET A CE  
4959 N  N   . PRO A 306 ? 0.12360 0.19050 0.19570 -0.01190 -0.01090 -0.05830 1765 PRO A N   
4960 C  CA  . PRO A 306 ? 0.13480 0.19110 0.24040 -0.02670 -0.03060 -0.05410 1765 PRO A CA  
4961 C  C   . PRO A 306 ? 0.14120 0.18110 0.25960 -0.04290 -0.02320 -0.03250 1765 PRO A C   
4962 O  O   . PRO A 306 ? 0.15680 0.20239 0.31310 -0.06990 -0.03320 0.00140  1765 PRO A O   
4963 C  CB  . PRO A 306 ? 0.20279 0.19520 0.25250 -0.00470 -0.00460 -0.06100 1765 PRO A CB  
4964 C  CG  . PRO A 306 ? 0.18920 0.19400 0.22960 -0.00180 0.00670  -0.06040 1765 PRO A CG  
4965 C  CD  . PRO A 306 ? 0.15480 0.18990 0.19570 -0.00920 -0.01340 -0.05910 1765 PRO A CD  
4973 N  N   . PHE A 307 ? 0.11980 0.15600 0.22640 -0.03070 -0.01700 -0.03820 1766 PHE A N   
4974 C  CA  . PHE A 307 ? 0.11090 0.15530 0.21300 -0.02900 -0.01010 -0.02470 1766 PHE A CA  
4975 C  C   . PHE A 307 ? 0.12800 0.15130 0.20180 -0.02610 -0.01060 -0.02220 1766 PHE A C   
4976 O  O   . PHE A 307 ? 0.15460 0.14570 0.22450 -0.02950 0.01030  0.00130  1766 PHE A O   
4977 C  CB  . PHE A 307 ? 0.11420 0.15020 0.22600 -0.03200 0.00800  -0.02100 1766 PHE A CB  
4978 C  CG  . PHE A 307 ? 0.14930 0.15390 0.20750 -0.01520 0.00150  -0.03600 1766 PHE A CG  
4979 C  CD1 . PHE A 307 ? 0.19480 0.15270 0.20210 -0.01810 0.00700  -0.03650 1766 PHE A CD1 
4980 C  CD2 . PHE A 307 ? 0.14730 0.16910 0.22890 -0.01270 0.02580  -0.03670 1766 PHE A CD2 
4981 C  CE1 . PHE A 307 ? 0.22999 0.15330 0.23940 -0.02270 0.01950  -0.04350 1766 PHE A CE1 
4982 C  CE2 . PHE A 307 ? 0.17090 0.18369 0.24190 -0.01560 0.05650  -0.03770 1766 PHE A CE2 
4983 C  CZ  . PHE A 307 ? 0.19420 0.18129 0.24960 -0.01770 0.03280  -0.05190 1766 PHE A CZ  
4993 N  N   . SER A 308 ? 0.11180 0.15120 0.17370 -0.01710 -0.00180 -0.01440 1767 SER A N   
4994 C  CA  A SER A 308 ? 0.12320 0.15440 0.15740 -0.01740 -0.00060 -0.01160 1767 SER A CA  
4995 C  CA  B SER A 308 ? 0.10390 0.15989 0.16570 -0.02360 0.01000  -0.02580 1767 SER A CA  
4996 C  C   . SER A 308 ? 0.11620 0.15620 0.17690 -0.01900 -0.00170 -0.01370 1767 SER A C   
4997 O  O   . SER A 308 ? 0.11760 0.15420 0.15400 -0.01570 -0.01360 -0.01480 1767 SER A O   
4998 C  CB  A SER A 308 ? 0.13020 0.15600 0.14570 -0.01800 -0.00070 -0.00820 1767 SER A CB  
4999 C  CB  B SER A 308 ? 0.11020 0.15190 0.16210 -0.02350 -0.02270 -0.01080 1767 SER A CB  
5000 O  OG  A SER A 308 ? 0.13300 0.15750 0.14220 -0.01840 -0.00060 -0.00610 1767 SER A OG  
5001 O  OG  B SER A 308 ? 0.09890 0.13800 0.18770 -0.01280 -0.00920 -0.00040 1767 SER A OG  
5012 N  N   . LYS A 309 ? 0.10270 0.15610 0.17820 -0.02370 0.01490  0.00610  1768 LYS A N   
5013 C  CA  . LYS A 309 ? 0.12250 0.17670 0.16830 -0.02450 0.02600  -0.00640 1768 LYS A CA  
5014 C  C   . LYS A 309 ? 0.11460 0.17490 0.18530 -0.01570 0.02230  -0.01850 1768 LYS A C   
5015 O  O   . LYS A 309 ? 0.11220 0.18200 0.25090 -0.00060 0.02620  0.01750  1768 LYS A O   
5016 C  CB  . LYS A 309 ? 0.12370 0.19430 0.18150 -0.03350 0.02280  0.00290  1768 LYS A CB  
5017 C  CG  . LYS A 309 ? 0.14420 0.20600 0.19510 -0.02390 0.00170  0.02500  1768 LYS A CG  
5018 C  CD  . LYS A 309 ? 0.17590 0.21880 0.23750 -0.05520 -0.03280 0.03660  1768 LYS A CD  
5019 C  CE  . LYS A 309 ? 0.22260 0.23979 0.29380 -0.06740 0.02430  0.03400  1768 LYS A CE  
5020 N  NZ  . LYS A 309 ? 0.29989 0.24400 0.32740 -0.06120 0.02540  0.03510  1768 LYS A NZ  
5034 N  N   . ALA A 310 ? 0.11100 0.16040 0.20850 -0.01320 -0.00800 -0.01480 1769 ALA A N   
5035 C  CA  . ALA A 310 ? 0.11070 0.15790 0.19490 -0.00130 0.00870  -0.01150 1769 ALA A CA  
5036 C  C   . ALA A 310 ? 0.09740 0.16710 0.17510 -0.00650 0.02460  -0.01420 1769 ALA A C   
5037 O  O   . ALA A 310 ? 0.08310 0.17870 0.20010 -0.01470 0.00560  -0.01640 1769 ALA A O   
5038 C  CB  . ALA A 310 ? 0.12320 0.14980 0.16640 0.00300  -0.00070 -0.01850 1769 ALA A CB  
5044 N  N   . HIS A 311 ? 0.10600 0.17250 0.18060 -0.01030 0.00460  -0.02000 1770 HIS A N   
5045 C  CA  . HIS A 311 ? 0.12090 0.17970 0.21050 -0.01980 -0.00760 -0.00800 1770 HIS A CA  
5046 C  C   . HIS A 311 ? 0.09750 0.17810 0.17460 -0.00620 -0.00690 -0.01310 1770 HIS A C   
5047 O  O   . HIS A 311 ? 0.11480 0.18330 0.21150 -0.01800 -0.02610 -0.01100 1770 HIS A O   
5048 C  CB  . HIS A 311 ? 0.14240 0.19690 0.21110 -0.04140 -0.01930 -0.00130 1770 HIS A CB  
5049 C  CG  . HIS A 311 ? 0.14340 0.21740 0.26250 -0.05070 -0.03350 -0.00280 1770 HIS A CG  
5050 N  ND1 . HIS A 311 ? 0.16350 0.23600 0.29450 -0.06730 -0.06160 -0.00570 1770 HIS A ND1 
5051 C  CD2 . HIS A 311 ? 0.17880 0.22170 0.28140 -0.06260 -0.01280 -0.02930 1770 HIS A CD2 
5052 C  CE1 . HIS A 311 ? 0.21580 0.24259 0.27510 -0.08280 -0.05130 -0.01990 1770 HIS A CE1 
5053 N  NE2 . HIS A 311 ? 0.25389 0.22880 0.27910 -0.09090 -0.01680 -0.04100 1770 HIS A NE2 
5061 N  N   . TRP A 312 ? 0.10900 0.17540 0.16380 -0.03050 0.00490  -0.00820 1771 TRP A N   
5062 C  CA  . TRP A 312 ? 0.10360 0.17640 0.14130 -0.02950 0.00390  0.00420  1771 TRP A CA  
5063 C  C   . TRP A 312 ? 0.09310 0.16550 0.16690 -0.03270 0.00060  -0.00820 1771 TRP A C   
5064 O  O   . TRP A 312 ? 0.09420 0.16550 0.20750 -0.00990 -0.01740 -0.01710 1771 TRP A O   
5065 C  CB  . TRP A 312 ? 0.09660 0.17760 0.12840 -0.02050 -0.00410 0.01340  1771 TRP A CB  
5066 C  CG  . TRP A 312 ? 0.09850 0.16740 0.13070 0.00070  -0.00060 -0.01100 1771 TRP A CG  
5067 C  CD1 . TRP A 312 ? 0.09920 0.16560 0.15550 -0.00110 -0.01100 -0.02060 1771 TRP A CD1 
5068 C  CD2 . TRP A 312 ? 0.07580 0.16460 0.14830 0.00710  0.00330  0.00240  1771 TRP A CD2 
5069 N  NE1 . TRP A 312 ? 0.10950 0.17070 0.14570 0.01530  -0.00680 -0.01760 1771 TRP A NE1 
5070 C  CE2 . TRP A 312 ? 0.09460 0.16590 0.14250 0.02050  -0.00440 0.00010  1771 TRP A CE2 
5071 C  CE3 . TRP A 312 ? 0.11230 0.15700 0.14540 0.01200  -0.01100 -0.01920 1771 TRP A CE3 
5072 C  CZ2 . TRP A 312 ? 0.10400 0.17090 0.16830 0.01800  -0.01900 -0.02960 1771 TRP A CZ2 
5073 C  CZ3 . TRP A 312 ? 0.10670 0.15530 0.10690 0.01390  0.00230  -0.00150 1771 TRP A CZ3 
5074 C  CH2 . TRP A 312 ? 0.10990 0.16600 0.14200 0.01880  -0.01560 -0.01980 1771 TRP A CH2 
5085 N  N   . THR A 313 ? 0.08180 0.17120 0.18400 -0.01810 0.01260  -0.01300 1772 THR A N   
5086 C  CA  . THR A 313 ? 0.09300 0.16990 0.17660 0.00470  0.00980  -0.01380 1772 THR A CA  
5087 C  C   . THR A 313 ? 0.09000 0.16640 0.17500 -0.00380 -0.00260 -0.01600 1772 THR A C   
5088 O  O   . THR A 313 ? 0.10170 0.17980 0.21280 0.00060  -0.00690 -0.00360 1772 THR A O   
5089 C  CB  . THR A 313 ? 0.10280 0.17260 0.15090 -0.01180 -0.00480 -0.03250 1772 THR A CB  
5090 O  OG1 . THR A 313 ? 0.09790 0.17240 0.14790 -0.00680 -0.00700 -0.02960 1772 THR A OG1 
5091 C  CG2 . THR A 313 ? 0.11970 0.17510 0.16850 0.00020  -0.00740 -0.02900 1772 THR A CG2 
5099 N  N   . PRO A 314 ? 0.09830 0.16070 0.15290 -0.01060 -0.01370 -0.00970 1773 PRO A N   
5100 C  CA  . PRO A 314 ? 0.11030 0.16180 0.17030 0.00760  -0.02550 0.00670  1773 PRO A CA  
5101 C  C   . PRO A 314 ? 0.12600 0.16290 0.16420 0.00740  -0.03020 0.00120  1773 PRO A C   
5102 O  O   . PRO A 314 ? 0.13360 0.16670 0.19550 0.01630  -0.00320 0.00630  1773 PRO A O   
5103 C  CB  . PRO A 314 ? 0.14240 0.16799 0.12670 0.00850  -0.01460 -0.00230 1773 PRO A CB  
5104 C  CG  . PRO A 314 ? 0.14020 0.15510 0.13170 0.00210  -0.01620 -0.00650 1773 PRO A CG  
5105 C  CD  . PRO A 314 ? 0.14630 0.16579 0.12800 -0.01330 0.00120  -0.00470 1773 PRO A CD  
5113 N  N   . PHE A 315 ? 0.12680 0.16410 0.14710 0.01890  -0.00830 -0.00880 1774 PHE A N   
5114 C  CA  . PHE A 315 ? 0.12140 0.18410 0.11830 0.01420  -0.02150 0.00200  1774 PHE A CA  
5115 C  C   . PHE A 315 ? 0.13390 0.20790 0.11360 0.00340  -0.02930 -0.01140 1774 PHE A C   
5116 O  O   . PHE A 315 ? 0.13450 0.21550 0.13800 0.00700  -0.01910 -0.01740 1774 PHE A O   
5117 C  CB  . PHE A 315 ? 0.12450 0.17280 0.15530 -0.00280 0.01610  -0.00590 1774 PHE A CB  
5118 C  CG  . PHE A 315 ? 0.10280 0.15620 0.16220 -0.00790 -0.00730 -0.01010 1774 PHE A CG  
5119 C  CD1 . PHE A 315 ? 0.10840 0.15110 0.15020 -0.00260 -0.01130 -0.00360 1774 PHE A CD1 
5120 C  CD2 . PHE A 315 ? 0.09150 0.14840 0.19770 -0.00050 -0.00930 -0.01010 1774 PHE A CD2 
5121 C  CE1 . PHE A 315 ? 0.11550 0.15040 0.15610 -0.01030 0.00250  -0.01390 1774 PHE A CE1 
5122 C  CE2 . PHE A 315 ? 0.09930 0.14880 0.19530 0.00210  -0.00460 -0.02030 1774 PHE A CE2 
5123 C  CZ  . PHE A 315 ? 0.10820 0.14430 0.17100 0.00150  0.00600  -0.03590 1774 PHE A CZ  
5133 N  N   . GLU A 316 ? 0.10910 0.21420 0.14650 -0.00990 -0.01570 -0.01310 1775 GLU A N   
5134 C  CA  . GLU A 316 ? 0.10640 0.22870 0.18110 0.00700  -0.02170 -0.01170 1775 GLU A CA  
5135 C  C   . GLU A 316 ? 0.10850 0.23850 0.17370 0.00750  -0.03070 -0.02660 1775 GLU A C   
5136 O  O   . GLU A 316 ? 0.12640 0.23470 0.24500 0.01890  -0.01780 -0.02940 1775 GLU A O   
5137 C  CB  . GLU A 316 ? 0.11570 0.23820 0.19830 -0.00600 -0.00430 -0.01450 1775 GLU A CB  
5138 C  CG  . GLU A 316 ? 0.11250 0.26800 0.22490 -0.01110 -0.01960 -0.02620 1775 GLU A CG  
5139 C  CD  . GLU A 316 ? 0.14060 0.31580 0.28900 -0.02490 -0.02130 -0.03520 1775 GLU A CD  
5140 O  OE1 . GLU A 316 ? 0.16780 0.35069 0.33540 -0.02200 0.03880  -0.05710 1775 GLU A OE1 
5141 O  OE2 . GLU A 316 ? 0.12780 0.32690 0.34190 -0.02870 -0.04090 -0.03290 1775 GLU A OE2 
5148 N  N   . GLY A 317 ? 0.12820 0.24780 0.15980 0.01750  -0.01090 -0.02230 1776 GLY A N   
5149 C  CA  . GLY A 317 ? 0.16550 0.26779 0.15150 0.02520  -0.03470 -0.01840 1776 GLY A CA  
5150 C  C   . GLY A 317 ? 0.19880 0.27170 0.14140 0.02560  -0.03990 -0.00750 1776 GLY A C   
5151 O  O   . GLY A 317 ? 0.20020 0.28300 0.17810 0.01260  -0.00730 0.01670  1776 GLY A O   
5155 N  N   . GLN A 318 ? 0.17860 0.26050 0.14440 0.02240  -0.04740 -0.01230 1777 GLN A N   
5156 C  CA  . GLN A 318 ? 0.17410 0.24790 0.13300 0.00150  -0.01090 -0.02380 1777 GLN A CA  
5157 C  C   . GLN A 318 ? 0.16470 0.24750 0.17690 -0.01590 -0.00570 -0.03110 1777 GLN A C   
5158 O  O   . GLN A 318 ? 0.17890 0.24300 0.20410 -0.02290 -0.00680 -0.02510 1777 GLN A O   
5159 C  CB  . GLN A 318 ? 0.19890 0.24380 0.16940 -0.00500 -0.01290 -0.01700 1777 GLN A CB  
5160 C  CG  . GLN A 318 ? 0.22290 0.25010 0.21300 0.01760  -0.02250 -0.02810 1777 GLN A CG  
5161 C  CD  . GLN A 318 ? 0.20040 0.24740 0.23580 0.02960  -0.00660 -0.03220 1777 GLN A CD  
5162 O  OE1 . GLN A 318 ? 0.22880 0.25950 0.28500 0.03400  -0.06830 -0.05540 1777 GLN A OE1 
5163 N  NE2 . GLN A 318 ? 0.20970 0.24790 0.21320 0.03100  -0.01670 -0.02380 1777 GLN A NE2 
5172 N  N   . LYS A 319 ? 0.18010 0.25300 0.19220 0.00630  -0.00080 -0.02690 1778 LYS A N   
5173 C  CA  A LYS A 319 ? 0.17880 0.25810 0.19800 -0.00970 -0.00240 -0.03960 1778 LYS A CA  
5174 C  CA  B LYS A 319 ? 0.18560 0.25940 0.20400 -0.00520 -0.00100 -0.04030 1778 LYS A CA  
5175 C  C   . LYS A 319 ? 0.15900 0.25600 0.21750 -0.01730 0.00350  -0.04620 1778 LYS A C   
5176 O  O   . LYS A 319 ? 0.16880 0.26320 0.26830 -0.01420 -0.00910 -0.05400 1778 LYS A O   
5177 C  CB  A LYS A 319 ? 0.21210 0.27740 0.23370 -0.00960 -0.01510 -0.03260 1778 LYS A CB  
5178 C  CB  B LYS A 319 ? 0.23190 0.28080 0.25040 0.00250  -0.01030 -0.03340 1778 LYS A CB  
5179 C  CG  A LYS A 319 ? 0.24410 0.29260 0.24600 -0.00400 -0.02410 -0.02270 1778 LYS A CG  
5180 C  CG  B LYS A 319 ? 0.27090 0.29490 0.28050 0.00950  -0.02010 -0.02030 1778 LYS A CG  
5181 C  CD  A LYS A 319 ? 0.27750 0.30840 0.29280 -0.00710 -0.02080 -0.00540 1778 LYS A CD  
5182 C  CD  B LYS A 319 ? 0.32160 0.30710 0.32170 0.01430  0.01090  0.00770  1778 LYS A CD  
5183 C  CE  A LYS A 319 ? 0.31050 0.32430 0.31190 -0.00360 -0.01360 0.01250  1778 LYS A CE  
5184 C  CE  B LYS A 319 ? 0.36460 0.31980 0.35800 0.02440  0.00100  0.02910  1778 LYS A CE  
5185 N  NZ  A LYS A 319 ? 0.33640 0.33540 0.33530 -0.00880 -0.01160 0.01050  1778 LYS A NZ  
5186 N  NZ  B LYS A 319 ? 0.38890 0.32800 0.37670 0.02790  -0.01930 0.04180  1778 LYS A NZ  
5213 N  N   . VAL A 320 ? 0.12740 0.25960 0.19690 -0.02260 0.00900  -0.04320 1779 VAL A N   
5214 C  CA  . VAL A 320 ? 0.13860 0.26950 0.14210 -0.03320 0.01670  -0.05050 1779 VAL A CA  
5215 C  C   . VAL A 320 ? 0.15620 0.27820 0.17130 -0.03680 0.01410  -0.05160 1779 VAL A C   
5216 O  O   . VAL A 320 ? 0.14470 0.29849 0.23320 -0.04020 -0.00700 -0.07040 1779 VAL A O   
5217 C  CB  . VAL A 320 ? 0.14260 0.27000 0.10910 -0.03650 0.02240  -0.05440 1779 VAL A CB  
5218 C  CG1 . VAL A 320 ? 0.14670 0.27340 0.18800 -0.02270 0.01090  -0.04520 1779 VAL A CG1 
5219 C  CG2 . VAL A 320 ? 0.17750 0.27270 0.16940 -0.03770 0.01050  -0.03720 1779 VAL A CG2 
5229 N  N   . LYS A 321 ? 0.15370 0.26810 0.20470 -0.01590 0.00500  -0.05700 1780 LYS A N   
5230 C  CA  . LYS A 321 ? 0.21000 0.27050 0.21810 0.00150  -0.01280 -0.05470 1780 LYS A CA  
5231 C  C   . LYS A 321 ? 0.18930 0.24310 0.21900 -0.01260 -0.01890 -0.04270 1780 LYS A C   
5232 O  O   . LYS A 321 ? 0.20220 0.22570 0.24880 -0.02330 -0.00370 -0.04110 1780 LYS A O   
5233 C  CB  . LYS A 321 ? 0.30609 0.30660 0.32830 -0.00600 0.01010  -0.03560 1780 LYS A CB  
5234 C  CG  . LYS A 321 ? 0.34960 0.34250 0.36700 0.00550  0.00890  -0.00630 1780 LYS A CG  
5235 C  CD  . LYS A 321 ? 0.38440 0.37660 0.37210 0.00240  -0.00890 0.00120  1780 LYS A CD  
5236 C  CE  . LYS A 321 ? 0.40650 0.39760 0.40020 0.00320  -0.00060 -0.00330 1780 LYS A CE  
5237 N  NZ  . LYS A 321 ? 0.41710 0.40700 0.40430 0.01390  0.00830  -0.00950 1780 LYS A NZ  
5251 N  N   . GLY A 322 ? 0.19360 0.21970 0.26250 -0.01610 -0.04620 -0.02960 1781 GLY A N   
5252 C  CA  . GLY A 322 ? 0.19350 0.19490 0.28100 0.00670  -0.03190 -0.03770 1781 GLY A CA  
5253 C  C   . GLY A 322 ? 0.17630 0.17890 0.25290 0.00340  -0.01060 -0.03750 1781 GLY A C   
5254 O  O   . GLY A 322 ? 0.20080 0.17560 0.26740 -0.00370 -0.02670 -0.06740 1781 GLY A O   
5258 N  N   . THR A 323 ? 0.16470 0.17370 0.20280 0.00140  -0.02090 -0.03730 1782 THR A N   
5259 C  CA  A THR A 323 ? 0.16390 0.18770 0.21860 0.00580  0.01410  -0.01990 1782 THR A CA  
5260 C  CA  B THR A 323 ? 0.16080 0.17510 0.18400 -0.00960 -0.00880 -0.03640 1782 THR A CA  
5261 C  C   . THR A 323 ? 0.16710 0.17100 0.19190 -0.00980 0.01100  -0.04110 1782 THR A C   
5262 O  O   . THR A 323 ? 0.15810 0.17660 0.20800 -0.01440 0.02980  -0.03720 1782 THR A O   
5263 C  CB  A THR A 323 ? 0.22060 0.20660 0.24480 0.00390  0.01690  -0.01930 1782 THR A CB  
5264 C  CB  B THR A 323 ? 0.17180 0.18070 0.17030 -0.03280 -0.01770 -0.03980 1782 THR A CB  
5265 O  OG1 A THR A 323 ? 0.23280 0.22659 0.29510 0.01070  0.05200  -0.02020 1782 THR A OG1 
5266 O  OG1 B THR A 323 ? 0.18600 0.18310 0.14250 -0.02650 -0.05620 -0.05050 1782 THR A OG1 
5267 C  CG2 A THR A 323 ? 0.21090 0.20400 0.21800 0.01910  -0.01330 -0.04370 1782 THR A CG2 
5268 C  CG2 B THR A 323 ? 0.17830 0.18520 0.16210 -0.05240 -0.01770 -0.03830 1782 THR A CG2 
5283 N  N   . VAL A 324 ? 0.16210 0.15630 0.20100 -0.01490 0.01320  -0.06020 1783 VAL A N   
5284 C  CA  . VAL A 324 ? 0.17560 0.14780 0.18720 -0.03230 0.01190  -0.04660 1783 VAL A CA  
5285 C  C   . VAL A 324 ? 0.15000 0.15600 0.20280 -0.03190 0.02370  -0.03990 1783 VAL A C   
5286 O  O   . VAL A 324 ? 0.13150 0.17829 0.26400 -0.03150 0.01700  -0.07310 1783 VAL A O   
5287 C  CB  . VAL A 324 ? 0.21340 0.14980 0.19550 -0.05430 0.00600  -0.03750 1783 VAL A CB  
5288 C  CG1 . VAL A 324 ? 0.21790 0.15860 0.24450 -0.05670 -0.02490 -0.04930 1783 VAL A CG1 
5289 C  CG2 . VAL A 324 ? 0.25770 0.15380 0.18070 -0.05770 -0.00160 -0.03270 1783 VAL A CG2 
5299 N  N   . ARG A 325 ? 0.14980 0.15120 0.20920 -0.03260 0.01680  -0.04860 1784 ARG A N   
5300 C  CA  . ARG A 325 ? 0.17530 0.15370 0.19500 -0.02990 0.00760  -0.02480 1784 ARG A CA  
5301 C  C   . ARG A 325 ? 0.18160 0.15020 0.20160 -0.03840 0.00870  -0.01580 1784 ARG A C   
5302 O  O   . ARG A 325 ? 0.21170 0.15910 0.22820 -0.08200 -0.02070 -0.01620 1784 ARG A O   
5303 C  CB  . ARG A 325 ? 0.21720 0.17420 0.20150 -0.02110 -0.00720 -0.02730 1784 ARG A CB  
5304 C  CG  . ARG A 325 ? 0.25230 0.18220 0.24610 -0.02970 0.00550  -0.04500 1784 ARG A CG  
5305 C  CD  . ARG A 325 ? 0.28060 0.20160 0.26070 -0.04250 0.00970  -0.03520 1784 ARG A CD  
5306 N  NE  . ARG A 325 ? 0.31770 0.22910 0.28480 -0.05980 0.01610  -0.00940 1784 ARG A NE  
5307 C  CZ  . ARG A 325 ? 0.37110 0.25310 0.32170 -0.05450 0.04200  0.01810  1784 ARG A CZ  
5308 N  NH1 . ARG A 325 ? 0.37660 0.27629 0.34600 -0.05290 0.05690  0.02910  1784 ARG A NH1 
5309 N  NH2 . ARG A 325 ? 0.41910 0.26140 0.35600 -0.03690 0.03550  0.00410  1784 ARG A NH2 
5323 N  N   . ARG A 326 ? 0.16030 0.14570 0.19590 -0.02830 0.02140  -0.03020 1785 ARG A N   
5324 C  CA  . ARG A 326 ? 0.18280 0.14760 0.20670 -0.02180 0.01730  -0.03580 1785 ARG A CA  
5325 C  C   . ARG A 326 ? 0.17430 0.13560 0.19330 -0.02550 0.02820  -0.03660 1785 ARG A C   
5326 O  O   . ARG A 326 ? 0.17930 0.15209 0.23520 -0.04500 0.02130  -0.02020 1785 ARG A O   
5327 C  CB  . ARG A 326 ? 0.22190 0.17500 0.22200 -0.01100 -0.01160 -0.03760 1785 ARG A CB  
5328 C  CG  . ARG A 326 ? 0.30590 0.21640 0.27580 0.00470  0.01060  -0.04880 1785 ARG A CG  
5329 C  CD  . ARG A 326 ? 0.33850 0.25110 0.34030 -0.01060 0.03200  -0.05070 1785 ARG A CD  
5330 N  NE  . ARG A 326 ? 0.34750 0.27840 0.36490 -0.02070 0.04660  -0.04320 1785 ARG A NE  
5331 C  CZ  . ARG A 326 ? 0.35100 0.29100 0.34420 -0.03780 0.03190  -0.03910 1785 ARG A CZ  
5332 N  NH1 . ARG A 326 ? 0.37540 0.30679 0.32780 -0.05320 0.02920  -0.06170 1785 ARG A NH1 
5333 N  NH2 . ARG A 326 ? 0.36090 0.28660 0.38430 -0.05540 0.03810  -0.02680 1785 ARG A NH2 
5347 N  N   . VAL A 327 ? 0.13850 0.11980 0.19680 -0.03250 0.01060  -0.03810 1786 VAL A N   
5348 C  CA  . VAL A 327 ? 0.14210 0.11990 0.17560 -0.02610 0.01680  -0.02460 1786 VAL A CA  
5349 C  C   . VAL A 327 ? 0.14280 0.11490 0.19530 -0.02500 0.02340  -0.02930 1786 VAL A C   
5350 O  O   . VAL A 327 ? 0.14260 0.11450 0.27720 -0.02290 0.02940  -0.01700 1786 VAL A O   
5351 C  CB  . VAL A 327 ? 0.16219 0.13190 0.18750 -0.01450 0.02470  -0.02270 1786 VAL A CB  
5352 C  CG1 . VAL A 327 ? 0.14290 0.14050 0.17740 -0.00580 0.00430  -0.02790 1786 VAL A CG1 
5353 C  CG2 . VAL A 327 ? 0.14320 0.12410 0.19660 -0.02110 0.00120  -0.01370 1786 VAL A CG2 
5363 N  N   . VAL A 328 ? 0.14120 0.11890 0.22490 -0.01360 0.01470  -0.01910 1787 VAL A N   
5364 C  CA  . VAL A 328 ? 0.16030 0.12280 0.23590 -0.00970 0.01960  -0.02750 1787 VAL A CA  
5365 C  C   . VAL A 328 ? 0.14800 0.11830 0.20060 -0.01660 0.03530  -0.01140 1787 VAL A C   
5366 O  O   . VAL A 328 ? 0.14350 0.11210 0.22050 -0.02380 0.02260  -0.01900 1787 VAL A O   
5367 C  CB  . VAL A 328 ? 0.17110 0.13590 0.22440 0.00610  0.03630  -0.04540 1787 VAL A CB  
5368 C  CG1 . VAL A 328 ? 0.17200 0.13390 0.25560 0.01110  0.05300  -0.05560 1787 VAL A CG1 
5369 C  CG2 . VAL A 328 ? 0.18000 0.14240 0.23910 0.00270  0.02520  -0.05930 1787 VAL A CG2 
5379 N  N   . LEU A 329 ? 0.15670 0.11810 0.18940 -0.01660 0.01350  -0.01910 1788 LEU A N   
5380 C  CA  . LEU A 329 ? 0.14630 0.11600 0.20010 -0.01030 0.00980  -0.02050 1788 LEU A CA  
5381 C  C   . LEU A 329 ? 0.11360 0.11580 0.21180 0.00490  0.00790  -0.02690 1788 LEU A C   
5382 O  O   . LEU A 329 ? 0.14430 0.11220 0.21910 -0.01310 0.02110  -0.03080 1788 LEU A O   
5383 C  CB  . LEU A 329 ? 0.15270 0.11160 0.20120 -0.01450 0.02320  -0.02320 1788 LEU A CB  
5384 C  CG  . LEU A 329 ? 0.13840 0.11460 0.22020 -0.01080 0.04930  -0.02110 1788 LEU A CG  
5385 C  CD1 . LEU A 329 ? 0.13930 0.11620 0.24790 -0.01140 0.00740  -0.01850 1788 LEU A CD1 
5386 C  CD2 . LEU A 329 ? 0.15480 0.13409 0.21420 0.00520  0.02140  -0.00730 1788 LEU A CD2 
5398 N  N   . ARG A 330 ? 0.13360 0.11430 0.23000 0.00640  0.02220  -0.00650 1789 ARG A N   
5399 C  CA  . ARG A 330 ? 0.14810 0.11280 0.21780 0.01050  0.02520  -0.03930 1789 ARG A CA  
5400 C  C   . ARG A 330 ? 0.15070 0.11420 0.23390 0.00690  0.03070  -0.03560 1789 ARG A C   
5401 O  O   . ARG A 330 ? 0.17700 0.11680 0.25510 0.00170  0.02340  -0.01560 1789 ARG A O   
5402 C  CB  . ARG A 330 ? 0.14970 0.11280 0.16520 0.00370  0.02530  -0.03260 1789 ARG A CB  
5403 C  CG  . ARG A 330 ? 0.15020 0.12580 0.18930 -0.00830 0.00040  -0.01510 1789 ARG A CG  
5404 C  CD  . ARG A 330 ? 0.15110 0.12650 0.21470 -0.00130 -0.00550 -0.02270 1789 ARG A CD  
5405 N  NE  . ARG A 330 ? 0.13240 0.12250 0.22530 -0.01420 0.01830  -0.02400 1789 ARG A NE  
5406 C  CZ  . ARG A 330 ? 0.16510 0.11620 0.20810 -0.00630 0.00840  -0.01430 1789 ARG A CZ  
5407 N  NH1 . ARG A 330 ? 0.19740 0.11380 0.20780 -0.00670 0.03540  -0.02380 1789 ARG A NH1 
5408 N  NH2 . ARG A 330 ? 0.16580 0.09810 0.25460 -0.01540 0.02540  -0.00770 1789 ARG A NH2 
5422 N  N   . GLY A 331 ? 0.16910 0.12480 0.22120 0.00920  0.03840  -0.03140 1790 GLY A N   
5423 C  CA  . GLY A 331 ? 0.17820 0.14849 0.21410 0.00360  0.01800  -0.06240 1790 GLY A CA  
5424 C  C   . GLY A 331 ? 0.17880 0.15530 0.24940 0.00370  0.02490  -0.07090 1790 GLY A C   
5425 O  O   . GLY A 331 ? 0.23370 0.18679 0.33100 -0.00170 0.04740  -0.10390 1790 GLY A O   
5429 N  N   . GLU A 332 ? 0.18570 0.13070 0.24400 0.00100  0.01970  -0.03620 1791 GLU A N   
5430 C  CA  . GLU A 332 ? 0.18910 0.13180 0.24620 -0.00960 -0.00610 -0.03620 1791 GLU A CA  
5431 C  C   . GLU A 332 ? 0.17750 0.12820 0.22620 0.00010  0.01780  -0.02880 1791 GLU A C   
5432 O  O   . GLU A 332 ? 0.16480 0.11690 0.26720 -0.01980 -0.01150 -0.03410 1791 GLU A O   
5433 C  CB  . GLU A 332 ? 0.21410 0.15350 0.25590 -0.01060 -0.02510 -0.01770 1791 GLU A CB  
5434 C  CG  . GLU A 332 ? 0.25500 0.17120 0.26340 -0.02210 -0.05640 -0.02120 1791 GLU A CG  
5435 C  CD  . GLU A 332 ? 0.33050 0.20820 0.37480 -0.01810 -0.04920 -0.03830 1791 GLU A CD  
5436 O  OE1 . GLU A 332 ? 0.34590 0.21840 0.43380 -0.05890 -0.04260 -0.03500 1791 GLU A OE1 
5437 O  OE2 . GLU A 332 ? 0.37900 0.22360 0.41630 0.00470  -0.03660 -0.05190 1791 GLU A OE2 
5444 N  N   . VAL A 333 ? 0.20020 0.13260 0.23100 0.00130  0.00520  -0.04350 1792 VAL A N   
5445 C  CA  . VAL A 333 ? 0.20730 0.13770 0.20700 -0.00700 0.02810  -0.04300 1792 VAL A CA  
5446 C  C   . VAL A 333 ? 0.19040 0.12980 0.20080 -0.02780 0.01140  -0.03100 1792 VAL A C   
5447 O  O   . VAL A 333 ? 0.21400 0.12610 0.22300 -0.04660 0.02180  -0.02250 1792 VAL A O   
5448 C  CB  . VAL A 333 ? 0.23030 0.16320 0.24000 0.02240  0.00020  -0.06300 1792 VAL A CB  
5449 C  CG1 . VAL A 333 ? 0.23700 0.17120 0.26470 0.02000  -0.03580 -0.04230 1792 VAL A CG1 
5450 C  CG2 . VAL A 333 ? 0.23440 0.18299 0.26150 0.03090  0.01010  -0.06450 1792 VAL A CG2 
5460 N  N   . ALA A 334 ? 0.16350 0.12870 0.23130 -0.02310 0.04600  -0.00790 1793 ALA A N   
5461 C  CA  . ALA A 334 ? 0.15300 0.13190 0.22850 -0.01830 0.01210  -0.02980 1793 ALA A CA  
5462 C  C   . ALA A 334 ? 0.15720 0.13720 0.19900 -0.02830 0.00370  -0.04500 1793 ALA A C   
5463 O  O   . ALA A 334 ? 0.15020 0.14630 0.21400 -0.03930 -0.01120 -0.04140 1793 ALA A O   
5464 C  CB  . ALA A 334 ? 0.16460 0.13820 0.25320 -0.02520 -0.01300 -0.05020 1793 ALA A CB  
5470 N  N   . TYR A 335 ? 0.14150 0.13460 0.22270 -0.03420 0.01420  -0.03090 1794 TYR A N   
5471 C  CA  . TYR A 335 ? 0.13710 0.13530 0.22070 -0.03210 -0.00420 -0.03400 1794 TYR A CA  
5472 C  C   . TYR A 335 ? 0.17080 0.13100 0.19860 -0.03500 0.00130  -0.03910 1794 TYR A C   
5473 O  O   . TYR A 335 ? 0.16740 0.13770 0.22050 -0.03030 0.02360  -0.03310 1794 TYR A O   
5474 C  CB  . TYR A 335 ? 0.14500 0.14640 0.21670 -0.03480 -0.01130 -0.05090 1794 TYR A CB  
5475 C  CG  . TYR A 335 ? 0.14230 0.14300 0.21830 -0.03530 -0.00430 -0.04440 1794 TYR A CG  
5476 C  CD1 . TYR A 335 ? 0.15930 0.14749 0.19640 -0.02120 0.00520  -0.03030 1794 TYR A CD1 
5477 C  CD2 . TYR A 335 ? 0.13700 0.13540 0.24690 -0.01020 -0.01280 -0.04690 1794 TYR A CD2 
5478 C  CE1 . TYR A 335 ? 0.16000 0.13390 0.20970 -0.01050 -0.00810 -0.04700 1794 TYR A CE1 
5479 C  CE2 . TYR A 335 ? 0.14280 0.13310 0.26490 -0.01810 0.00590  -0.05760 1794 TYR A CE2 
5480 C  CZ  . TYR A 335 ? 0.15660 0.13850 0.23150 -0.00610 -0.02060 -0.05630 1794 TYR A CZ  
5481 O  OH  . TYR A 335 ? 0.16040 0.15270 0.29950 -0.00770 -0.03310 -0.03920 1794 TYR A OH  
5491 N  N   A ILE A 336 ? 0.19150 0.13750 0.20550 -0.03350 0.01820  -0.03960 1795 ILE A N   
5492 N  N   B ILE A 336 ? 0.18700 0.13880 0.20280 -0.04600 0.00610  -0.05480 1795 ILE A N   
5493 C  CA  A ILE A 336 ? 0.21180 0.15030 0.21170 -0.04380 0.02450  -0.04670 1795 ILE A CA  
5494 C  CA  B ILE A 336 ? 0.19950 0.15840 0.20150 -0.06970 0.01510  -0.05740 1795 ILE A CA  
5495 C  C   A ILE A 336 ? 0.22460 0.17070 0.20080 -0.05320 0.01540  -0.03880 1795 ILE A C   
5496 C  C   B ILE A 336 ? 0.21180 0.17510 0.19010 -0.07280 -0.00070 -0.04670 1795 ILE A C   
5497 O  O   A ILE A 336 ? 0.22520 0.17620 0.21200 -0.06090 0.03330  -0.04530 1795 ILE A O   
5498 O  O   B ILE A 336 ? 0.19630 0.17600 0.15260 -0.08510 0.00210  -0.06230 1795 ILE A O   
5499 C  CB  A ILE A 336 ? 0.23740 0.14940 0.23710 -0.03750 0.04940  -0.05830 1795 ILE A CB  
5500 C  CB  B ILE A 336 ? 0.23470 0.17050 0.21900 -0.07350 0.04180  -0.06440 1795 ILE A CB  
5501 C  CG1 A ILE A 336 ? 0.23500 0.15210 0.23790 0.00330  0.07240  -0.05230 1795 ILE A CG1 
5502 C  CG1 B ILE A 336 ? 0.22670 0.16890 0.24820 -0.07310 0.04630  -0.07070 1795 ILE A CG1 
5503 C  CG2 A ILE A 336 ? 0.21940 0.14890 0.23950 -0.05770 0.05150  -0.05840 1795 ILE A CG2 
5504 C  CG2 B ILE A 336 ? 0.24890 0.18599 0.25510 -0.06800 -0.01070 -0.04720 1795 ILE A CG2 
5505 C  CD1 A ILE A 336 ? 0.25430 0.15420 0.24960 0.02070  0.02900  -0.04190 1795 ILE A CD1 
5506 C  CD1 B ILE A 336 ? 0.23980 0.16410 0.23940 -0.07080 0.05740  -0.07440 1795 ILE A CD1 
5529 N  N   . ASP A 337 ? 0.23720 0.17950 0.20340 -0.06590 -0.00330 -0.03630 1796 ASP A N   
5530 C  CA  . ASP A 337 ? 0.24560 0.20920 0.21130 -0.07120 0.00340  -0.04330 1796 ASP A CA  
5531 C  C   . ASP A 337 ? 0.23680 0.20170 0.22140 -0.07570 0.00620  -0.03760 1796 ASP A C   
5532 O  O   . ASP A 337 ? 0.21380 0.18010 0.23640 -0.04740 -0.01320 -0.06120 1796 ASP A O   
5533 C  CB  . ASP A 337 ? 0.26130 0.23659 0.22030 -0.10270 -0.00920 -0.04970 1796 ASP A CB  
5534 C  CG  . ASP A 337 ? 0.25740 0.24240 0.19710 -0.12040 -0.01690 -0.05460 1796 ASP A CG  
5535 O  OD1 . ASP A 337 ? 0.32279 0.25660 0.21560 -0.14730 0.00050  -0.05350 1796 ASP A OD1 
5536 O  OD2 . ASP A 337 ? 0.20880 0.23990 0.21600 -0.09200 -0.01850 -0.02670 1796 ASP A OD2 
5541 N  N   . GLY A 338 ? 0.28310 0.21240 0.25120 -0.08910 0.01250  -0.05830 1797 GLY A N   
5542 C  CA  . GLY A 338 ? 0.29130 0.21150 0.23700 -0.08710 0.01660  -0.06420 1797 GLY A CA  
5543 C  C   . GLY A 338 ? 0.28120 0.21900 0.23420 -0.09080 0.02600  -0.06890 1797 GLY A C   
5544 O  O   . GLY A 338 ? 0.35109 0.23020 0.30910 -0.06350 0.06350  -0.08120 1797 GLY A O   
5548 N  N   . GLN A 339 ? 0.23920 0.23799 0.19490 -0.10070 -0.00630 -0.06280 1798 GLN A N   
5549 C  CA  . GLN A 339 ? 0.22880 0.23780 0.21180 -0.10340 0.00730  -0.06380 1798 GLN A CA  
5550 C  C   . GLN A 339 ? 0.21970 0.22520 0.18370 -0.07910 0.01740  -0.07450 1798 GLN A C   
5551 O  O   . GLN A 339 ? 0.19540 0.22920 0.22810 -0.07850 0.03060  -0.06990 1798 GLN A O   
5552 C  CB  . GLN A 339 ? 0.25890 0.24920 0.24100 -0.12950 0.01330  -0.06760 1798 GLN A CB  
5553 C  CG  . GLN A 339 ? 0.27380 0.27310 0.30670 -0.11370 0.01640  -0.05690 1798 GLN A CG  
5554 C  CD  . GLN A 339 ? 0.27590 0.30130 0.35480 -0.07730 -0.01230 -0.05800 1798 GLN A CD  
5555 O  OE1 . GLN A 339 ? 0.25400 0.30860 0.41120 -0.06450 -0.06010 -0.07180 1798 GLN A OE1 
5556 N  NE2 . GLN A 339 ? 0.26820 0.31909 0.35860 -0.06210 -0.00710 -0.06160 1798 GLN A NE2 
5565 N  N   . VAL A 340 ? 0.18180 0.22330 0.16700 -0.06730 0.01390  -0.06440 1799 VAL A N   
5566 C  CA  . VAL A 340 ? 0.18140 0.22540 0.16050 -0.05230 0.01340  -0.06730 1799 VAL A CA  
5567 C  C   . VAL A 340 ? 0.17540 0.20610 0.22130 -0.06760 0.02210  -0.07340 1799 VAL A C   
5568 O  O   . VAL A 340 ? 0.20610 0.22140 0.32969 -0.08620 0.01480  -0.06160 1799 VAL A O   
5569 C  CB  . VAL A 340 ? 0.24350 0.25430 0.12510 -0.03020 0.01310  -0.07820 1799 VAL A CB  
5570 C  CG1 . VAL A 340 ? 0.27160 0.26590 0.14380 -0.01700 -0.03140 -0.08420 1799 VAL A CG1 
5571 C  CG2 . VAL A 340 ? 0.25040 0.26700 0.18100 -0.02010 0.03480  -0.07850 1799 VAL A CG2 
5581 N  N   . LEU A 341 ? 0.18990 0.18760 0.23790 -0.04850 0.03030  -0.08260 1800 LEU A N   
5582 C  CA  . LEU A 341 ? 0.22540 0.18680 0.24840 -0.05770 0.03120  -0.10020 1800 LEU A CA  
5583 C  C   . LEU A 341 ? 0.24990 0.15550 0.27540 -0.02980 -0.00460 -0.07250 1800 LEU A C   
5584 O  O   . LEU A 341 ? 0.31889 0.14770 0.35460 -0.02100 -0.01070 -0.08240 1800 LEU A O   
5585 C  CB  . LEU A 341 ? 0.24390 0.22860 0.23720 -0.06450 0.01700  -0.12340 1800 LEU A CB  
5586 C  CG  . LEU A 341 ? 0.25360 0.27640 0.25710 -0.08290 0.03360  -0.09080 1800 LEU A CG  
5587 C  CD1 . LEU A 341 ? 0.30530 0.30679 0.28470 -0.07840 0.01710  -0.07640 1800 LEU A CD1 
5588 C  CD2 . LEU A 341 ? 0.27430 0.27900 0.34150 -0.08680 -0.00200 -0.08620 1800 LEU A CD2 
5600 N  N   . VAL A 342 ? 0.18800 0.14590 0.22130 -0.02360 0.00850  -0.05240 1801 VAL A N   
5601 C  CA  . VAL A 342 ? 0.18970 0.14540 0.23300 -0.01340 0.03120  -0.02690 1801 VAL A CA  
5602 C  C   . VAL A 342 ? 0.20830 0.14130 0.25470 -0.02010 0.02360  -0.02330 1801 VAL A C   
5603 O  O   . VAL A 342 ? 0.20340 0.14340 0.23780 -0.02970 0.03820  -0.02420 1801 VAL A O   
5604 C  CB  . VAL A 342 ? 0.17700 0.14800 0.23560 -0.01790 0.01800  -0.03470 1801 VAL A CB  
5605 C  CG1 . VAL A 342 ? 0.17590 0.15310 0.25980 -0.01320 0.01550  -0.02170 1801 VAL A CG1 
5606 C  CG2 . VAL A 342 ? 0.18700 0.14990 0.24080 -0.02000 0.03130  -0.03550 1801 VAL A CG2 
5616 N  N   . PRO A 343 ? 0.20220 0.12890 0.27620 -0.03410 0.03380  -0.00820 1802 PRO A N   
5617 C  CA  . PRO A 343 ? 0.21750 0.12790 0.27160 -0.03880 0.03760  -0.00080 1802 PRO A CA  
5618 C  C   . PRO A 343 ? 0.18890 0.13190 0.24690 -0.02350 0.03120  -0.00180 1802 PRO A C   
5619 O  O   . PRO A 343 ? 0.17110 0.13210 0.25020 -0.02530 0.02980  0.00030  1802 PRO A O   
5620 C  CB  . PRO A 343 ? 0.25290 0.12250 0.30840 -0.02520 0.04180  -0.00220 1802 PRO A CB  
5621 C  CG  . PRO A 343 ? 0.26550 0.12150 0.27870 -0.02230 0.05990  0.00700  1802 PRO A CG  
5622 C  CD  . PRO A 343 ? 0.23660 0.12790 0.24850 -0.01940 0.03140  -0.01360 1802 PRO A CD  
5630 N  N   . PRO A 344 ? 0.17390 0.13310 0.22410 -0.03840 0.03330  -0.00640 1803 PRO A N   
5631 C  CA  . PRO A 344 ? 0.16390 0.13050 0.21150 -0.03140 0.04490  -0.01760 1803 PRO A CA  
5632 C  C   . PRO A 344 ? 0.15900 0.13030 0.25540 -0.03060 0.01720  0.00300  1803 PRO A C   
5633 O  O   . PRO A 344 ? 0.18110 0.11880 0.27430 -0.03640 0.02470  0.01810  1803 PRO A O   
5634 C  CB  . PRO A 344 ? 0.18880 0.14080 0.25000 -0.03160 0.02600  -0.00940 1803 PRO A CB  
5635 C  CG  . PRO A 344 ? 0.17750 0.15269 0.27090 -0.02470 0.02100  0.00330  1803 PRO A CG  
5636 C  CD  . PRO A 344 ? 0.17960 0.14830 0.26510 -0.03610 0.01240  -0.00810 1803 PRO A CD  
5644 N  N   . GLY A 345 ? 0.15260 0.14249 0.23020 -0.02160 0.03660  -0.00190 1804 GLY A N   
5645 C  CA  . GLY A 345 ? 0.17390 0.13350 0.22870 -0.02550 0.03270  -0.00070 1804 GLY A CA  
5646 C  C   . GLY A 345 ? 0.16490 0.10970 0.21590 -0.02400 0.03420  -0.01310 1804 GLY A C   
5647 O  O   . GLY A 345 ? 0.16690 0.11820 0.25150 -0.02550 0.01910  -0.00870 1804 GLY A O   
5651 N  N   . TYR A 346 ? 0.16250 0.10600 0.24250 -0.02060 0.03930  -0.01540 1805 TYR A N   
5652 C  CA  . TYR A 346 ? 0.15670 0.10540 0.23730 -0.02240 0.04010  0.00040  1805 TYR A CA  
5653 C  C   . TYR A 346 ? 0.14000 0.10400 0.24940 -0.00860 0.01270  0.00300  1805 TYR A C   
5654 O  O   . TYR A 346 ? 0.13850 0.10470 0.26870 -0.00860 0.01080  -0.01210 1805 TYR A O   
5655 C  CB  . TYR A 346 ? 0.16510 0.10810 0.24670 -0.01860 0.04080  -0.02050 1805 TYR A CB  
5656 C  CG  . TYR A 346 ? 0.16120 0.11230 0.24780 -0.02220 0.03940  -0.02460 1805 TYR A CG  
5657 C  CD1 . TYR A 346 ? 0.17970 0.11890 0.25120 -0.01960 0.03970  -0.02080 1805 TYR A CD1 
5658 C  CD2 . TYR A 346 ? 0.16380 0.10600 0.23140 -0.02470 0.01440  -0.00260 1805 TYR A CD2 
5659 C  CE1 . TYR A 346 ? 0.20090 0.12140 0.25080 -0.00750 0.04970  -0.00810 1805 TYR A CE1 
5660 C  CE2 . TYR A 346 ? 0.15900 0.10780 0.24960 -0.02120 0.04050  -0.01720 1805 TYR A CE2 
5661 C  CZ  . TYR A 346 ? 0.16740 0.11400 0.23230 -0.00630 0.06080  -0.01560 1805 TYR A CZ  
5662 O  OH  . TYR A 346 ? 0.18750 0.10690 0.25590 -0.00450 0.05340  -0.02070 1805 TYR A OH  
5672 N  N   . GLY A 347 ? 0.13400 0.08840 0.24930 -0.01010 0.01160  0.00110  1806 GLY A N   
5673 C  CA  . GLY A 347 ? 0.12880 0.09500 0.23420 -0.00800 0.02350  0.01010  1806 GLY A CA  
5674 C  C   . GLY A 347 ? 0.14460 0.09640 0.22650 -0.01150 0.03080  -0.00180 1806 GLY A C   
5675 O  O   . GLY A 347 ? 0.15650 0.10310 0.21930 -0.00350 0.02160  -0.01190 1806 GLY A O   
5679 N  N   . GLN A 348 ? 0.13110 0.08450 0.22150 -0.00740 0.00070  -0.00360 1807 GLN A N   
5680 C  CA  . GLN A 348 ? 0.13890 0.09550 0.21530 -0.00130 -0.00380 -0.00260 1807 GLN A CA  
5681 C  C   . GLN A 348 ? 0.12170 0.10350 0.20980 -0.00070 0.01680  0.00660  1807 GLN A C   
5682 O  O   . GLN A 348 ? 0.12770 0.10620 0.21120 -0.00550 0.01810  0.01510  1807 GLN A O   
5683 C  CB  . GLN A 348 ? 0.14900 0.09910 0.23070 -0.00280 -0.00280 -0.01320 1807 GLN A CB  
5684 C  CG  . GLN A 348 ? 0.15480 0.10650 0.22210 0.00370  0.00510  -0.02260 1807 GLN A CG  
5685 C  CD  . GLN A 348 ? 0.16820 0.11240 0.29390 -0.00010 0.00010  -0.02010 1807 GLN A CD  
5686 O  OE1 . GLN A 348 ? 0.16550 0.11840 0.36280 -0.00550 0.00870  -0.04680 1807 GLN A OE1 
5687 N  NE2 . GLN A 348 ? 0.19850 0.11650 0.29510 0.02640  -0.01930 -0.02790 1807 GLN A NE2 
5696 N  N   . ASP A 349 ? 0.12940 0.10040 0.23250 -0.00790 0.00900  0.01040  1808 ASP A N   
5697 C  CA  . ASP A 349 ? 0.13340 0.09600 0.21960 -0.00410 0.00550  -0.00860 1808 ASP A CA  
5698 C  C   . ASP A 349 ? 0.12190 0.08940 0.21270 0.00430  0.00300  -0.01030 1808 ASP A C   
5699 O  O   . ASP A 349 ? 0.12600 0.10190 0.22190 0.00390  -0.00810 0.01480  1808 ASP A O   
5700 C  CB  . ASP A 349 ? 0.15180 0.10300 0.21410 -0.00260 0.02910  0.00690  1808 ASP A CB  
5701 C  CG  . ASP A 349 ? 0.14990 0.11820 0.19320 -0.01020 0.03020  0.01370  1808 ASP A CG  
5702 O  OD1 . ASP A 349 ? 0.13060 0.11140 0.22160 -0.00060 0.01460  0.01240  1808 ASP A OD1 
5703 O  OD2 . ASP A 349 ? 0.22189 0.14619 0.21540 -0.03760 0.03250  -0.01350 1808 ASP A OD2 
5708 N  N   . VAL A 350 ? 0.11990 0.08030 0.20910 -0.00050 0.01230  0.01360  1809 VAL A N   
5709 C  CA  . VAL A 350 ? 0.14620 0.09590 0.18310 0.00030  0.01190  0.00300  1809 VAL A CA  
5710 C  C   . VAL A 350 ? 0.13760 0.09910 0.16610 -0.00770 0.03420  -0.00370 1809 VAL A C   
5711 O  O   . VAL A 350 ? 0.11250 0.11230 0.23600 -0.00090 0.01860  -0.01370 1809 VAL A O   
5712 C  CB  . VAL A 350 ? 0.15280 0.09960 0.19910 -0.01410 0.01940  -0.00550 1809 VAL A CB  
5713 C  CG1 . VAL A 350 ? 0.17710 0.10520 0.19080 -0.01790 0.03150  -0.01890 1809 VAL A CG1 
5714 C  CG2 . VAL A 350 ? 0.15380 0.09320 0.20480 0.01200  0.02310  0.01610  1809 VAL A CG2 
5724 N  N   . ARG A 351 ? 0.13550 0.10840 0.17740 -0.01030 0.01300  -0.00570 1810 ARG A N   
5725 C  CA  . ARG A 351 ? 0.14230 0.12040 0.18830 -0.00200 -0.00100 0.00860  1810 ARG A CA  
5726 C  C   . ARG A 351 ? 0.15240 0.12660 0.22000 -0.00540 -0.01390 0.00410  1810 ARG A C   
5727 O  O   . ARG A 351 ? 0.17570 0.13300 0.28150 0.00440  -0.05050 -0.00100 1810 ARG A O   
5728 C  CB  . ARG A 351 ? 0.15590 0.11770 0.18080 -0.00630 0.01310  0.02000  1810 ARG A CB  
5729 C  CG  . ARG A 351 ? 0.13770 0.11780 0.18670 0.00070  0.01120  0.00610  1810 ARG A CG  
5730 C  CD  . ARG A 351 ? 0.14310 0.11700 0.21500 -0.01980 0.02810  0.01830  1810 ARG A CD  
5731 N  NE  . ARG A 351 ? 0.15749 0.10600 0.17420 -0.00470 0.02490  0.02200  1810 ARG A NE  
5732 C  CZ  . ARG A 351 ? 0.11210 0.11170 0.15970 -0.00330 0.02730  0.01620  1810 ARG A CZ  
5733 N  NH1 . ARG A 351 ? 0.11930 0.11920 0.18500 0.00640  0.01020  0.01850  1810 ARG A NH1 
5734 N  NH2 . ARG A 351 ? 0.10820 0.11420 0.18220 -0.00410 0.01720  0.02690  1810 ARG A NH2 
5748 N  N   . LYS A 352 ? 0.15160 0.11980 0.23770 0.00740  -0.02080 0.01460  1811 LYS A N   
5749 C  CA  . LYS A 352 ? 0.17140 0.13900 0.22360 0.01380  -0.00920 0.03600  1811 LYS A CA  
5750 C  C   . LYS A 352 ? 0.17580 0.13660 0.22440 0.01530  -0.01200 0.04060  1811 LYS A C   
5751 O  O   . LYS A 352 ? 0.20910 0.15459 0.30050 0.03120  -0.00650 0.08410  1811 LYS A O   
5752 C  CB  . LYS A 352 ? 0.22060 0.17529 0.24950 0.01270  0.03570  0.04900  1811 LYS A CB  
5755 N  N   . TRP A 353 ? 0.15020 0.13410 0.24960 0.03370  -0.00610 0.02620  1812 TRP A N   
5756 C  CA  . TRP A 353 ? 0.14040 0.13680 0.27310 0.01860  0.01470  0.01430  1812 TRP A CA  
5757 C  C   . TRP A 353 ? 0.14190 0.17120 0.29170 0.01930  0.00250  0.03370  1812 TRP A C   
5758 O  O   . TRP A 353 ? 0.16090 0.17360 0.27810 -0.00750 -0.01650 0.02640  1812 TRP A O   
5759 C  CB  . TRP A 353 ? 0.13270 0.13380 0.24170 0.00680  0.00820  -0.00290 1812 TRP A CB  
5760 C  CG  . TRP A 353 ? 0.13610 0.12370 0.23320 0.00580  0.02580  0.00670  1812 TRP A CG  
5761 C  CD1 . TRP A 353 ? 0.15350 0.12880 0.23810 0.00150  0.02910  0.01770  1812 TRP A CD1 
5762 C  CD2 . TRP A 353 ? 0.14000 0.11220 0.24150 0.00180  0.01910  -0.00590 1812 TRP A CD2 
5763 N  NE1 . TRP A 353 ? 0.14700 0.12340 0.23340 -0.01610 0.01990  0.00760  1812 TRP A NE1 
5764 C  CE2 . TRP A 353 ? 0.14240 0.11950 0.21890 0.00340  0.03420  0.00750  1812 TRP A CE2 
5765 C  CE3 . TRP A 353 ? 0.16500 0.11390 0.22380 -0.00730 0.02240  -0.00120 1812 TRP A CE3 
5766 C  CZ2 . TRP A 353 ? 0.14690 0.12070 0.21670 -0.01070 0.04130  -0.01400 1812 TRP A CZ2 
5767 C  CZ3 . TRP A 353 ? 0.19770 0.12290 0.23630 -0.01690 0.03010  0.00070  1812 TRP A CZ3 
5768 C  CH2 . TRP A 353 ? 0.18690 0.11830 0.23430 -0.01960 0.03480  0.00120  1812 TRP A CH2 
5779 N  N   . PRO A 354 ? 0.16130 0.19980 0.36060 0.02680  -0.00380 0.03280  1813 PRO A N   
5780 C  CA  . PRO A 354 ? 0.18140 0.21900 0.36180 0.01790  -0.01020 0.04390  1813 PRO A CA  
5781 C  C   . PRO A 354 ? 0.17550 0.23330 0.31690 -0.01290 -0.01090 0.01730  1813 PRO A C   
5782 O  O   . PRO A 354 ? 0.18660 0.25519 0.35660 -0.02930 -0.00850 0.02890  1813 PRO A O   
5783 C  CB  . PRO A 354 ? 0.20150 0.22840 0.39870 0.04420  0.00350  0.05640  1813 PRO A CB  
5784 C  CG  . PRO A 354 ? 0.22160 0.22910 0.42870 0.05160  -0.01370 0.02660  1813 PRO A CG  
5785 C  CD  . PRO A 354 ? 0.20170 0.21770 0.39210 0.05100  0.01540  0.01770  1813 PRO A CD  
5793 N  N   . GLN A 355 ? 0.16050 0.22660 0.28050 -0.00710 0.02960  -0.00520 1814 GLN A N   
5794 C  CA  . GLN A 355 ? 0.18840 0.23709 0.25910 -0.00780 0.02160  0.00780  1814 GLN A CA  
5795 C  C   . GLN A 355 ? 0.14910 0.21940 0.29230 -0.01520 0.01690  0.00880  1814 GLN A C   
5796 O  O   . GLN A 355 ? 0.14360 0.23519 0.35450 -0.02260 0.02460  0.00800  1814 GLN A O   
5797 C  CB  . GLN A 355 ? 0.24229 0.24610 0.30810 0.01120  0.01180  0.01540  1814 GLN A CB  
5798 C  CG  . GLN A 355 ? 0.23020 0.24250 0.33330 0.02940  0.00490  0.01660  1814 GLN A CG  
5799 C  CD  . GLN A 355 ? 0.19300 0.23360 0.30150 0.03450  0.01100  0.00490  1814 GLN A CD  
5800 O  OE1 . GLN A 355 ? 0.20760 0.22320 0.35470 0.04900  -0.02590 -0.00610 1814 GLN A OE1 
5801 N  NE2 . GLN A 355 ? 0.25149 0.24010 0.35320 0.04780  0.02590  0.01880  1814 GLN A NE2 
5810 N  N   . GLY A 356 ? 0.13420 0.19080 0.26160 -0.01870 0.01350  -0.00240 1815 GLY A N   
5811 C  CA  . GLY A 356 ? 0.14060 0.16770 0.23110 -0.02540 0.00930  0.00210  1815 GLY A CA  
5812 C  C   . GLY A 356 ? 0.13740 0.15620 0.23520 -0.01230 -0.01470 0.02800  1815 GLY A C   
5813 O  O   . GLY A 356 ? 0.14740 0.14550 0.29200 0.01760  0.01810  0.03300  1815 GLY A O   
5817 N  N   . ALA A 357 ? 0.15800 0.16180 0.21700 -0.01230 -0.01100 0.01650  1816 ALA A N   
5818 C  CA  . ALA A 357 ? 0.17150 0.19410 0.23570 -0.02350 0.00490  0.01260  1816 ALA A CA  
5819 C  C   . ALA A 357 ? 0.17370 0.20340 0.22780 -0.04760 0.04210  -0.00360 1816 ALA A C   
5820 O  O   . ALA A 357 ? 0.19330 0.20800 0.24790 -0.04550 0.05400  -0.02260 1816 ALA A O   
5821 C  CB  . ALA A 357 ? 0.23599 0.21349 0.25630 -0.03170 0.00500  0.01790  1816 ALA A CB  
5827 N  N   . VAL A 358 ? 0.19320 0.19610 0.24880 -0.05010 0.04250  -0.00540 1817 VAL A N   
5828 C  CA  . VAL A 358 ? 0.19620 0.19610 0.22970 -0.06730 0.02830  -0.00810 1817 VAL A CA  
5829 C  C   . VAL A 358 ? 0.18030 0.20590 0.21140 -0.06050 0.04580  -0.02640 1817 VAL A C   
5830 O  O   . VAL A 358 ? 0.16270 0.19630 0.25200 -0.03390 0.00980  0.00050  1817 VAL A O   
5831 C  CB  . VAL A 358 ? 0.20570 0.20630 0.17490 -0.04650 -0.00670 0.00650  1817 VAL A CB  
5832 C  CG1 . VAL A 358 ? 0.21230 0.21090 0.16250 -0.03690 -0.03770 0.00730  1817 VAL A CG1 
5833 C  CG2 . VAL A 358 ? 0.20010 0.22030 0.19950 -0.02650 -0.02630 0.01610  1817 VAL A CG2 
5843 N  N   . PRO A 359 ? 0.19210 0.24780 0.23020 -0.07820 0.06670  -0.03680 1818 PRO A N   
5844 C  CA  . PRO A 359 ? 0.17120 0.25970 0.24580 -0.06540 0.05310  -0.01530 1818 PRO A CA  
5845 C  C   . PRO A 359 ? 0.17270 0.24940 0.21600 -0.05190 0.01950  0.02020  1818 PRO A C   
5846 O  O   . PRO A 359 ? 0.20190 0.22500 0.20510 -0.06630 -0.01320 0.02580  1818 PRO A O   
5847 C  CB  . PRO A 359 ? 0.22210 0.27920 0.29000 -0.07390 0.05570  -0.02990 1818 PRO A CB  
5848 C  CG  . PRO A 359 ? 0.24390 0.28549 0.30140 -0.08980 0.04170  -0.04030 1818 PRO A CG  
5849 C  CD  . PRO A 359 ? 0.22650 0.27140 0.25370 -0.10470 0.06100  -0.05150 1818 PRO A CD  
5857 N  N   . GLN A 360 ? 0.16790 0.26840 0.26620 -0.01260 0.02000  0.04750  1819 GLN A N   
5858 C  CA  . GLN A 360 ? 0.16370 0.31550 0.27480 0.01540  0.00760  0.04670  1819 GLN A CA  
5859 C  C   . GLN A 360 ? 0.19180 0.33960 0.30500 0.03800  -0.01170 0.04220  1819 GLN A C   
5860 O  O   . GLN A 360 ? 0.17540 0.34390 0.33610 0.04570  0.01420  0.04520  1819 GLN A O   
5861 C  CB  . GLN A 360 ? 0.18050 0.33780 0.29890 0.02720  -0.00640 0.05870  1819 GLN A CB  
5862 C  CG  . GLN A 360 ? 0.22440 0.35160 0.32090 0.03020  0.02530  0.05330  1819 GLN A CG  
5863 C  CD  . GLN A 360 ? 0.29810 0.37280 0.33170 0.03860  0.00450  0.03640  1819 GLN A CD  
5864 O  OE1 . GLN A 360 ? 0.33570 0.39289 0.35430 0.04270  -0.01890 0.04000  1819 GLN A OE1 
5865 N  NE2 . GLN A 360 ? 0.31160 0.37630 0.33650 0.02480  0.02150  0.03680  1819 GLN A NE2 
5874 N  N   . LEU A 361 ? 0.20200 0.35960 0.30670 0.03590  -0.02870 0.03710  1820 LEU A N   
5875 C  CA  . LEU A 361 ? 0.26470 0.37730 0.31120 0.03580  -0.03710 0.05500  1820 LEU A CA  
5876 C  C   . LEU A 361 ? 0.33320 0.39790 0.32230 0.04210  -0.00050 0.07850  1820 LEU A C   
5877 O  O   . LEU A 361 ? 0.36720 0.40850 0.32180 0.03640  0.02560  0.10060  1820 LEU A O   
5878 C  CB  . LEU A 361 ? 0.28400 0.37900 0.32700 0.01950  -0.04210 0.04830  1820 LEU A CB  
5879 C  CG  . LEU A 361 ? 0.32830 0.37520 0.33980 0.00400  -0.05070 0.04550  1820 LEU A CG  
5880 C  CD1 . LEU A 361 ? 0.36400 0.38050 0.37700 0.00120  -0.05480 0.03660  1820 LEU A CD1 
5881 C  CD2 . LEU A 361 ? 0.32240 0.37160 0.31060 -0.00040 -0.04420 0.05630  1820 LEU A CD2 
5893 N  N   . PRO A 362 ? 0.40570 0.40780 0.33150 0.03260  -0.00550 0.06810  1821 PRO A N   
5894 C  CA  . PRO A 362 ? 0.45490 0.42130 0.41270 0.02590  0.01450  0.04280  1821 PRO A CA  
5895 C  C   . PRO A 362 ? 0.50980 0.43610 0.46670 0.00190  0.03470  0.01570  1821 PRO A C   
5896 O  O   . PRO A 362 ? 0.52470 0.43760 0.47120 -0.00490 0.01930  0.00580  1821 PRO A O   
5897 C  CB  . PRO A 362 ? 0.44830 0.42280 0.41300 0.04200  -0.00230 0.04690  1821 PRO A CB  
5898 C  CG  . PRO A 362 ? 0.43910 0.41710 0.38980 0.05250  -0.00400 0.05660  1821 PRO A CG  
5899 C  CD  . PRO A 362 ? 0.41990 0.40940 0.35840 0.04820  -0.01820 0.05660  1821 PRO A CD  
5900 O  OXT . PRO A 362 ? 0.54650 0.44980 0.52590 0.00030  0.04200  0.00170  1821 PRO A OXT 
5908 ZN ZN  . ZN  B .   ? 0.08957 0.11228 0.17919 -0.00460 0.00750  0.00550  1901 ZN  A ZN  
5909 ZN ZN  . ZN  C .   ? 0.09631 0.11082 0.16230 -0.01600 -0.01240 0.00830  1902 ZN  A ZN  
5910 C  C6  A NCD D .   ? 0.10610 0.12210 0.15150 -0.00410 -0.03010 0.00520  1903 NCD A C6  
5911 C  C61 A NCD D .   ? 0.07970 0.11830 0.10860 -0.00830 -0.02230 0.01200  1903 NCD A C61 
5912 O  O61 A NCD D .   ? 0.09170 0.11850 0.09250 -0.00360 -0.00170 0.00670  1903 NCD A O61 
5913 O  O62 A NCD D .   ? 0.07360 0.11120 0.14990 -0.01380 -0.02140 0.00250  1903 NCD A O62 
5914 N  N1  A NCD D .   ? 0.08080 0.10790 0.10580 0.00830  -0.00630 -0.01150 1903 NCD A N1  
5915 C  C2  A NCD D .   ? 0.08870 0.11789 0.14120 -0.00190 -0.03850 0.00240  1903 NCD A C2  
5916 O  O2  A NCD D .   ? 0.06130 0.10670 0.12610 0.00040  0.00910  -0.02120 1903 NCD A O2  
5917 N  N3  A NCD D .   ? 0.08160 0.11990 0.18440 0.00250  -0.02960 0.02600  1903 NCD A N3  
5918 C  C5  A NCD D .   ? 0.16339 0.13029 0.15310 0.00390  -0.02090 0.00700  1903 NCD A C5  
5919 C  C4  A NCD D .   ? 0.11000 0.10960 0.13900 0.01920  -0.01640 0.00060  1903 NCD A C4  
5920 O  O4  A NCD D .   ? 0.07880 0.08000 0.10970 0.03310  -0.00330 -0.00930 1903 NCD A O4  
5921 O  O5  A NCD D .   ? 0.08760 0.12200 0.17360 0.00920  0.02840  0.00810  1903 NCD A O5  
5928 ZN ZN  . ZN  E .   ? 0.09920 0.09940 0.16190 -0.00600 0.00600  -0.00220 1904 ZN  A ZN  
5929 O  O2  B DOR F .   ? 0.14610 0.15910 0.16480 -0.04250 -0.00020 0.00200  1905 DOR A O2  
5930 C  C2  B DOR F .   ? 0.17230 0.14880 0.16220 -0.02260 -0.02860 -0.02950 1905 DOR A C2  
5931 N  N1  B DOR F .   ? 0.19210 0.13450 0.15710 -0.02970 -0.03420 -0.06620 1905 DOR A N1  
5932 N  N3  B DOR F .   ? 0.13950 0.14000 0.10740 -0.00710 -0.03640 -0.03010 1905 DOR A N3  
5933 C  C4  B DOR F .   ? 0.10750 0.12450 0.11680 -0.00100 -0.02800 -0.04080 1905 DOR A C4  
5934 O  O4  B DOR F .   ? 0.11600 0.11590 0.15140 0.01110  -0.02970 -0.04570 1905 DOR A O4  
5935 C  C5  B DOR F .   ? 0.17449 0.13530 0.15850 -0.01020 -0.05030 -0.01630 1905 DOR A C5  
5936 C  C6  B DOR F .   ? 0.17670 0.14090 0.18380 -0.01700 -0.02150 -0.03620 1905 DOR A C6  
5937 C  C7  B DOR F .   ? 0.15170 0.15560 0.20260 -0.02230 0.00070  -0.02220 1905 DOR A C7  
5938 O  O72 B DOR F .   ? 0.14050 0.16210 0.21340 -0.01890 0.01630  -0.04080 1905 DOR A O72 
5939 O  O71 B DOR F .   ? 0.13680 0.16310 0.20760 -0.02410 0.00240  -0.00210 1905 DOR A O71 
5945 C  C   . FMT G .   ? 0.17480 0.27300 0.23690 -0.06910 -0.01440 0.06940  1906 FMT A C   
5946 O  O1  . FMT G .   ? 0.16680 0.27330 0.23060 -0.07340 0.00130  0.02840  1906 FMT A O1  
5947 O  O2  . FMT G .   ? 0.25249 0.28540 0.28840 -0.10000 -0.03060 0.07240  1906 FMT A O2  
5950 C  C   . FMT H .   ? 0.08490 0.11879 0.14520 -0.00150 -0.02780 -0.00110 1907 FMT A C   
5951 O  O1  . FMT H .   ? 0.10100 0.09980 0.08680 0.03780  -0.01360 0.00210  1907 FMT A O1  
5952 O  O2  . FMT H .   ? 0.09620 0.11200 0.21630 0.01930  -0.02360 -0.02580 1907 FMT A O2  
5955 C  C   . FMT I .   ? 0.50120 0.40760 0.50050 -0.01690 0.04000  -0.11310 1908 FMT A C   
5956 O  O1  . FMT I .   ? 0.51570 0.41830 0.48540 -0.01960 0.02950  -0.08960 1908 FMT A O1  
5957 O  O2  . FMT I .   ? 0.50650 0.39520 0.51360 -0.01820 0.02800  -0.13570 1908 FMT A O2  
5960 C  C   . FMT J .   ? 0.53740 0.51640 0.51250 -0.05370 -0.05700 0.02020  1909 FMT A C   
5961 O  O1  . FMT J .   ? 0.54470 0.51570 0.52420 -0.05610 -0.05010 0.00090  1909 FMT A O1  
5962 O  O2  . FMT J .   ? 0.51380 0.51220 0.48600 -0.04940 -0.06220 0.03960  1909 FMT A O2  
5965 C  C   . FMT K .   ? 0.64670 0.62620 0.62450 -0.00590 -0.07770 -0.00270 1910 FMT A C   
5966 O  O1  . FMT K .   ? 0.63560 0.62450 0.61480 0.00530  -0.09170 -0.00500 1910 FMT A O1  
5967 O  O2  . FMT K .   ? 0.64980 0.62680 0.63500 -0.01290 -0.06430 -0.00220 1910 FMT A O2  
5970 C  C   . FMT L .   ? 0.60830 0.58160 0.57230 -0.03330 0.04720  -0.01750 1911 FMT A C   
5971 O  O1  . FMT L .   ? 0.63480 0.58590 0.57190 -0.04100 0.04830  -0.01540 1911 FMT A O1  
5972 O  O2  . FMT L .   ? 0.59720 0.57880 0.58270 -0.02900 0.03400  -0.02220 1911 FMT A O2  
5975 C  C   . FMT M .   ? 0.63340 0.61960 0.61050 -0.02880 0.02430  -0.02100 1912 FMT A C   
5976 O  O1  . FMT M .   ? 0.64610 0.62220 0.63000 -0.02780 0.02890  -0.01230 1912 FMT A O1  
5977 O  O2  . FMT M .   ? 0.62370 0.61620 0.60250 -0.03240 0.02610  -0.02090 1912 FMT A O2  
5980 ZN ZN  . ZN  N .   ? 0.11599 0.13809 0.20850 0.00430  0.00710  0.02120  1913 ZN  A ZN  
5981 C  C   . FMT O .   ? 0.42380 0.44420 0.35370 0.01300  0.05370  -0.04900 1914 FMT A C   
5982 O  O1  . FMT O .   ? 0.43140 0.43730 0.40230 -0.01300 0.04640  -0.05640 1914 FMT A O1  
5983 O  O2  . FMT O .   ? 0.44320 0.45610 0.44050 0.01940  0.02430  -0.03270 1914 FMT A O2  
5986 C  C   . FMT P .   ? 0.40650 0.40780 0.36770 -0.03130 0.03050  -0.00850 1915 FMT A C   
5987 O  O1  . FMT P .   ? 0.42600 0.41220 0.38870 -0.03950 0.04290  -0.00510 1915 FMT A O1  
5988 O  O2  . FMT P .   ? 0.42000 0.40680 0.39570 -0.01610 0.04220  -0.00200 1915 FMT A O2  
5991 C  C   . FMT Q .   ? 0.25150 0.25620 0.25420 0.00420  0.01430  0.00780  1916 FMT A C   
5992 O  O1  . FMT Q .   ? 0.28420 0.27669 0.27300 -0.00610 -0.00410 0.00290  1916 FMT A O1  
5993 O  O2  . FMT Q .   ? 0.26370 0.27649 0.26830 0.00530  -0.00210 -0.00280 1916 FMT A O2  
5996 C  C   . FMT R .   ? 0.55790 0.59290 0.56400 -0.00220 0.00290  -0.01570 1917 FMT A C   
5997 O  O1  . FMT R .   ? 0.54890 0.58960 0.58630 -0.00310 0.02180  -0.01230 1917 FMT A O1  
5998 O  O2  . FMT R .   ? 0.57400 0.59830 0.56280 -0.00860 -0.01530 -0.01760 1917 FMT A O2  
6001 O  O   . HOH S .   ? 0.39930 0.46070 0.49540 0.00160  0.24990  0.00190  2001 HOH A O   
6002 O  O   . HOH S .   ? 0.54610 0.32840 0.48250 -0.23000 -0.08310 0.01730  2002 HOH A O   
6003 O  O   . HOH S .   ? 0.49050 0.46930 0.45700 0.00720  -0.02560 -0.00250 2003 HOH A O   
6004 O  O   . HOH S .   ? 0.29080 0.24660 0.37100 0.03630  0.02580  0.07990  2004 HOH A O   
6005 O  O   . HOH S .   ? 0.17570 0.15100 0.26640 -0.07460 0.04180  -0.00580 2005 HOH A O   
6006 O  O   . HOH S .   ? 0.57510 0.58600 0.53130 -0.00310 0.02500  0.02570  2006 HOH A O   
6007 O  O   . HOH S .   ? 0.38080 0.47590 0.35400 0.11460  0.01240  -0.00010 2007 HOH A O   
6008 O  O   . HOH S .   ? 0.38000 0.38000 0.38000 -0.00000 0.00000  -0.00000 2008 HOH A O   
6009 O  O   . HOH S .   ? 0.33610 0.31380 0.40380 -0.06230 0.02720  0.11390  2009 HOH A O   
6010 O  O   . HOH S .   ? 0.19180 0.36650 0.40430 -0.00260 0.03250  0.06050  2010 HOH A O   
6011 O  O   . HOH S .   ? 0.18950 0.54110 0.45510 -0.03160 -0.03430 0.03910  2011 HOH A O   
6012 O  O   . HOH S .   ? 0.43120 0.45160 0.60600 0.11730  -0.05190 0.04900  2012 HOH A O   
6013 O  O   . HOH S .   ? 0.36770 0.39350 0.41660 -0.05200 -0.04810 0.08210  2013 HOH A O   
6014 O  O   . HOH S .   ? 0.47590 0.33250 0.48460 0.04130  -0.06420 0.05100  2014 HOH A O   
6015 O  O   . HOH S .   ? 0.45480 0.46580 0.47640 -0.08310 0.01660  0.02220  2015 HOH A O   
6016 O  O   . HOH S .   ? 0.45940 0.57250 0.53620 -0.06500 -0.00470 -0.04130 2016 HOH A O   
6017 O  O   . HOH S .   ? 0.43200 0.59320 0.53440 0.09880  -0.13500 0.09820  2017 HOH A O   
6018 O  O   . HOH S .   ? 0.38330 0.38680 0.46900 0.02160  0.07930  -0.05140 2018 HOH A O   
6019 O  O   . HOH S .   ? 0.28110 0.44120 0.36470 -0.00060 0.12280  -0.08200 2019 HOH A O   
6020 O  O   . HOH S .   ? 0.29830 0.41640 0.36840 0.04030  0.00060  -0.09420 2020 HOH A O   
6021 O  O   . HOH S .   ? 0.57990 0.50480 0.56460 -0.02880 0.16320  -0.00590 2021 HOH A O   
6022 O  O   . HOH S .   ? 0.39280 0.60760 0.46620 0.13010  0.10300  -0.01920 2022 HOH A O   
6023 O  O   . HOH S .   ? 0.34080 0.46280 0.36500 0.10320  0.10180  0.09460  2023 HOH A O   
6024 O  O   . HOH S .   ? 0.46270 0.42510 0.42110 -0.01290 0.00890  0.04930  2024 HOH A O   
6025 O  O   . HOH S .   ? 0.13270 0.22420 0.26670 -0.01420 0.01670  -0.01380 2025 HOH A O   
6026 O  O   . HOH S .   ? 0.25070 0.43830 0.43490 -0.04420 0.06680  0.11110  2026 HOH A O   
6027 O  O   . HOH S .   ? 0.27520 0.40010 0.32230 -0.00630 -0.08530 0.03080  2027 HOH A O   
6028 O  O   . HOH S .   ? 0.40250 0.30680 0.29410 -0.07960 0.02490  0.01340  2028 HOH A O   
6029 O  O   . HOH S .   ? 0.29560 0.36800 0.37679 0.17119  0.09290  0.13900  2029 HOH A O   
6030 O  O   . HOH S .   ? 0.53240 0.42930 0.49330 0.04460  -0.05240 0.13010  2030 HOH A O   
6031 O  O   . HOH S .   ? 0.23660 0.51210 0.31810 -0.08720 -0.07230 -0.03060 2031 HOH A O   
6032 O  O   . HOH S .   ? 0.28260 0.15970 0.17840 0.09510  -0.05900 -0.02180 2032 HOH A O   
6033 O  O   . HOH S .   ? 0.60150 0.43050 0.54160 0.08940  0.00330  -0.13900 2033 HOH A O   
6034 O  O   . HOH S .   ? 0.30600 0.39130 0.35250 -0.06880 -0.05830 0.16470  2034 HOH A O   
6035 O  O   . HOH S .   ? 0.22480 0.31810 0.39450 -0.10700 -0.05230 0.02620  2035 HOH A O   
6036 O  O   . HOH S .   ? 0.14040 0.15990 0.19360 -0.00420 0.00880  -0.01950 2036 HOH A O   
6037 O  O   . HOH S .   ? 0.23510 0.35860 0.36450 -0.08900 0.02610  -0.06700 2037 HOH A O   
6038 O  O   . HOH S .   ? 0.14400 0.15130 0.18920 0.02700  -0.02630 -0.03690 2038 HOH A O   
6039 O  O   . HOH S .   ? 0.41370 0.43090 0.40340 0.03190  -0.01360 0.01020  2039 HOH A O   
6040 O  O   . HOH S .   ? 0.52980 0.30990 0.33320 -0.13090 0.15740  0.04300  2040 HOH A O   
6041 O  O   . HOH S .   ? 0.17080 0.37940 0.31320 -0.02650 0.03750  -0.04280 2041 HOH A O   
6042 O  O   . HOH S .   ? 0.50120 0.35590 0.38880 -0.05790 -0.05930 -0.02820 2042 HOH A O   
6043 O  O   . HOH S .   ? 0.36520 0.56280 0.40090 -0.03700 -0.08620 0.03000  2043 HOH A O   
6044 O  O   . HOH S .   ? 0.25410 0.25670 0.33860 0.00800  0.02140  0.12170  2044 HOH A O   
6045 O  O   . HOH S .   ? 0.45290 0.48070 0.44810 0.01530  -0.00350 -0.05180 2045 HOH A O   
6046 O  O   . HOH S .   ? 0.51360 0.47090 0.51350 -0.01600 -0.00310 -0.01280 2046 HOH A O   
6047 O  O   . HOH S .   ? 0.38940 0.38770 0.38540 -0.00220 0.00180  -0.00110 2047 HOH A O   
6048 O  O   . HOH S .   ? 0.24840 0.34610 0.30320 -0.07740 0.04040  0.03510  2048 HOH A O   
6049 O  O   . HOH S .   ? 0.27830 0.13300 0.19700 -0.02010 0.01730  -0.00670 2049 HOH A O   
6050 O  O   . HOH S .   ? 0.35820 0.28920 0.46080 -0.11310 0.02130  0.03570  2050 HOH A O   
6051 O  O   . HOH S .   ? 0.37750 0.38560 0.47850 -0.13230 0.06510  -0.07850 2051 HOH A O   
6052 O  O   . HOH S .   ? 0.27610 0.37000 0.36000 -0.16590 -0.05910 -0.02690 2052 HOH A O   
6053 O  O   . HOH S .   ? 0.47430 0.42610 0.42040 0.04850  -0.04200 0.02350  2053 HOH A O   
6054 O  O   . HOH S .   ? 0.25990 0.42860 0.50260 -0.14050 0.04770  -0.01850 2054 HOH A O   
6055 O  O   . HOH S .   ? 0.20800 0.28070 0.21770 -0.06240 -0.05970 0.03270  2055 HOH A O   
6056 O  O   . HOH S .   ? 0.51970 0.38460 0.40760 -0.07730 -0.15000 -0.04330 2056 HOH A O   
6057 O  O   . HOH S .   ? 0.29450 0.14560 0.38920 -0.00550 -0.06320 -0.02930 2057 HOH A O   
6058 O  O   . HOH S .   ? 0.29820 0.32790 0.42140 0.07320  0.01480  -0.11380 2058 HOH A O   
6059 O  O   . HOH S .   ? 0.35590 0.53320 0.50180 0.04400  -0.03510 -0.00880 2059 HOH A O   
6060 O  O   . HOH S .   ? 0.16520 0.12090 0.33020 -0.00790 0.01270  0.05610  2060 HOH A O   
6061 O  O   . HOH S .   ? 0.20200 0.31720 0.32630 0.01310  0.00140  0.00910  2061 HOH A O   
6062 O  O   . HOH S .   ? 0.47720 0.38720 0.52480 0.01950  0.05800  0.08260  2062 HOH A O   
6063 O  O   . HOH S .   ? 0.52130 0.48580 0.39410 0.05810  -0.17670 0.01660  2063 HOH A O   
6064 O  O   . HOH S .   ? 0.30530 0.17580 0.30650 -0.06090 -0.05660 -0.02180 2064 HOH A O   
6065 O  O   . HOH S .   ? 0.49360 0.51090 0.53870 -0.02670 0.02400  -0.03750 2065 HOH A O   
6066 O  O   . HOH S .   ? 0.32520 0.46710 0.43990 -0.07340 0.08590  -0.02010 2066 HOH A O   
6067 O  O   . HOH S .   ? 0.21280 0.32430 0.34700 0.02810  0.02000  -0.02370 2067 HOH A O   
6068 O  O   . HOH S .   ? 0.29210 0.34340 0.28020 -0.05180 0.01230  -0.00300 2068 HOH A O   
6069 O  O   . HOH S .   ? 0.26910 0.36750 0.36840 -0.00870 -0.00060 -0.12700 2069 HOH A O   
6070 O  O   . HOH S .   ? 0.47640 0.24650 0.32460 0.13080  0.21570  0.09060  2070 HOH A O   
6071 O  O   . HOH S .   ? 0.50900 0.42490 0.51980 0.03330  0.04140  -0.04240 2071 HOH A O   
6072 O  O   . HOH S .   ? 0.18450 0.36410 0.21730 0.01950  -0.05650 0.07750  2072 HOH A O   
6073 O  O   . HOH S .   ? 0.46370 0.26390 0.38000 0.04600  -0.05940 -0.04270 2073 HOH A O   
6074 O  O   . HOH S .   ? 0.39160 0.29190 0.23880 0.06840  -0.08930 -0.05900 2074 HOH A O   
6075 O  O   . HOH S .   ? 0.23490 0.32270 0.40590 0.00240  -0.05290 0.01920  2075 HOH A O   
6076 O  O   . HOH S .   ? 0.09670 0.10960 0.18820 -0.00460 0.00000  -0.00950 2076 HOH A O   
6077 O  O   . HOH S .   ? 0.35590 0.33430 0.32620 -0.11840 0.00750  -0.09170 2077 HOH A O   
6078 O  O   . HOH S .   ? 0.11280 0.11900 0.21930 -0.02660 0.00810  -0.00170 2078 HOH A O   
6079 O  O   . HOH S .   ? 0.47850 0.50820 0.45640 -0.15120 0.00370  -0.10490 2079 HOH A O   
6080 O  O   . HOH S .   ? 0.40360 0.51190 0.39570 -0.03010 0.06090  0.11400  2080 HOH A O   
6081 O  O   . HOH S .   ? 0.56030 0.41320 0.45780 0.00310  -0.08200 -0.03090 2081 HOH A O   
6082 O  O   . HOH S .   ? 0.43740 0.59240 0.47990 0.08000  0.01590  -0.01160 2082 HOH A O   
6083 O  O   . HOH S .   ? 0.35630 0.26670 0.35290 -0.02230 0.01050  -0.04220 2083 HOH A O   
6084 O  O   . HOH S .   ? 0.32380 0.19960 0.32280 -0.09480 -0.02390 -0.00490 2084 HOH A O   
6085 O  O   . HOH S .   ? 0.18380 0.54750 0.35690 0.06710  -0.03510 0.05670  2085 HOH A O   
6086 O  O   . HOH S .   ? 0.31130 0.35190 0.28120 0.03240  -0.00730 0.01570  2086 HOH A O   
6087 O  O   . HOH S .   ? 0.33780 0.26240 0.38930 -0.02790 -0.00590 -0.09080 2087 HOH A O   
6088 O  O   . HOH S .   ? 0.13980 0.27230 0.25150 -0.03180 0.02610  -0.03680 2088 HOH A O   
6089 O  O   . HOH S .   ? 0.08550 0.15230 0.19250 -0.00360 -0.01750 -0.01540 2089 HOH A O   
6090 O  O   . HOH S .   ? 0.21840 0.28570 0.32190 -0.02760 0.02120  -0.07650 2090 HOH A O   
6091 O  O   . HOH S .   ? 0.34480 0.40930 0.39990 0.04600  -0.06630 0.11270  2091 HOH A O   
6092 O  O   . HOH S .   ? 0.31260 0.49870 0.23270 -0.04510 -0.04990 0.12590  2092 HOH A O   
6093 O  O   . HOH S .   ? 0.26380 0.31020 0.40940 -0.10890 -0.11450 -0.03310 2093 HOH A O   
6094 O  O   . HOH S .   ? 0.34250 0.17720 0.34120 0.02660  -0.02020 -0.01990 2094 HOH A O   
6095 O  O   . HOH S .   ? 0.32130 0.27280 0.36300 0.05140  -0.06440 0.03740  2095 HOH A O   
6096 O  O   . HOH S .   ? 0.37050 0.43520 0.35710 0.07740  -0.04300 -0.02970 2096 HOH A O   
6097 O  O   . HOH S .   ? 0.32300 0.30380 0.35370 -0.08800 0.00440  0.07140  2097 HOH A O   
6098 O  O   . HOH S .   ? 0.10830 0.13730 0.17070 0.00120  -0.00420 -0.02050 2098 HOH A O   
6099 O  O   . HOH S .   ? 0.11300 0.11950 0.15740 0.00000  0.00110  -0.01640 2099 HOH A O   
6100 O  O   . HOH S .   ? 0.13780 0.11460 0.19380 0.00550  0.01690  -0.01030 2100 HOH A O   
6101 O  O   . HOH S .   ? 0.38280 0.32120 0.46430 0.09920  0.06080  0.02080  2101 HOH A O   
6102 O  O   . HOH S .   ? 0.16500 0.20980 0.27080 0.01630  0.00450  0.01270  2102 HOH A O   
6103 O  O   . HOH S .   ? 0.19730 0.21530 0.28040 0.04810  0.02490  -0.03450 2103 HOH A O   
6104 O  O   . HOH S .   ? 0.15350 0.19890 0.20420 0.00350  -0.01420 -0.05580 2104 HOH A O   
6105 O  O   . HOH S .   ? 0.31270 0.41970 0.32910 -0.11670 -0.01520 0.05650  2105 HOH A O   
6106 O  O   . HOH S .   ? 0.21230 0.27430 0.33490 0.07230  -0.06930 -0.02040 2106 HOH A O   
6107 O  O   . HOH S .   ? 0.16750 0.40350 0.42990 -0.03420 -0.03560 0.04120  2107 HOH A O   
6108 O  O   . HOH S .   ? 0.18910 0.25160 0.29630 -0.02610 0.01830  -0.06310 2108 HOH A O   
6109 O  O   . HOH S .   ? 0.41610 0.61190 0.47940 0.01910  0.02930  -0.05040 2109 HOH A O   
6110 O  O   . HOH S .   ? 0.17500 0.55119 0.27020 0.09790  0.01520  0.09340  2110 HOH A O   
6111 O  O   . HOH S .   ? 0.17840 0.29680 0.29650 -0.03500 -0.03750 0.02000  2111 HOH A O   
6112 O  O   . HOH S .   ? 0.38850 0.24850 0.34870 -0.00830 -0.01060 -0.10960 2112 HOH A O   
6113 O  O   . HOH S .   ? 0.27950 0.57440 0.39350 0.05810  -0.10260 -0.04010 2113 HOH A O   
6114 O  O   . HOH S .   ? 0.15020 0.27040 0.26610 -0.04970 0.02430  -0.05960 2114 HOH A O   
6115 O  O   . HOH S .   ? 0.22850 0.15690 0.37520 0.00240  0.02460  0.01230  2115 HOH A O   
6116 O  O   . HOH S .   ? 0.26810 0.22470 0.30400 -0.05300 0.01400  -0.00920 2116 HOH A O   
6117 O  O   . HOH S .   ? 0.28050 0.19610 0.27810 -0.03890 0.00500  -0.05450 2117 HOH A O   
6118 O  O   . HOH S .   ? 0.44430 0.23110 0.31170 -0.07380 0.04110  -0.00140 2118 HOH A O   
6119 O  O   . HOH S .   ? 0.11610 0.17100 0.22590 -0.00370 -0.01220 -0.02440 2119 HOH A O   
6120 O  O   . HOH S .   ? 0.33400 0.32400 0.36830 0.06590  -0.07890 0.09660  2120 HOH A O   
6121 O  O   . HOH S .   ? 0.22720 0.40210 0.21030 0.10520  -0.02890 -0.00130 2121 HOH A O   
6122 O  O   . HOH S .   ? 0.16150 0.13100 0.23920 0.01710  0.04930  -0.01250 2122 HOH A O   
6123 O  O   . HOH S .   ? 0.23430 0.26660 0.36540 0.01930  0.03630  0.02870  2123 HOH A O   
6124 O  O   . HOH S .   ? 0.21440 0.30110 0.32770 -0.07330 0.02850  0.07900  2124 HOH A O   
6125 O  O   . HOH S .   ? 0.22950 0.36390 0.24220 -0.02180 0.04210  -0.04880 2125 HOH A O   
6126 O  O   . HOH S .   ? 0.18560 0.19920 0.26600 -0.03790 0.00900  0.00870  2126 HOH A O   
6127 O  O   . HOH S .   ? 0.27090 0.41070 0.36850 -0.11210 0.07370  0.08260  2127 HOH A O   
6128 O  O   . HOH S .   ? 0.15320 0.21050 0.15770 0.02450  0.01930  -0.00120 2128 HOH A O   
6129 O  O   . HOH S .   ? 0.21170 0.14390 0.23610 -0.01500 0.02300  -0.00230 2129 HOH A O   
6130 O  O   . HOH S .   ? 0.20350 0.42820 0.38000 -0.02080 -0.00030 -0.04680 2130 HOH A O   
6131 O  O   . HOH S .   ? 0.34740 0.28400 0.48680 0.04420  0.14940  -0.11190 2131 HOH A O   
6132 O  O   . HOH S .   ? 0.28820 0.20300 0.33750 -0.04470 -0.00590 0.07000  2132 HOH A O   
6133 O  O   . HOH S .   ? 0.31040 0.43250 0.38300 0.15830  0.09070  -0.02430 2133 HOH A O   
6134 O  O   . HOH S .   ? 0.25530 0.36940 0.21940 -0.05060 -0.03200 0.02450  2134 HOH A O   
6135 O  O   . HOH S .   ? 0.25820 0.35320 0.19970 -0.07980 0.08840  -0.01870 2135 HOH A O   
6136 O  O   . HOH S .   ? 0.09710 0.12280 0.14640 0.02100  -0.00570 -0.01450 2136 HOH A O   
6137 O  O   . HOH S .   ? 0.26500 0.29910 0.26220 0.06410  0.00970  -0.02410 2137 HOH A O   
6138 O  O   . HOH S .   ? 0.55360 0.35390 0.52410 -0.16440 -0.03280 -0.06660 2138 HOH A O   
6139 O  O   . HOH S .   ? 0.32400 0.28440 0.28880 -0.09880 0.04450  -0.01470 2139 HOH A O   
6140 O  O   . HOH S .   ? 0.35810 0.46220 0.43660 0.05050  -0.07150 -0.06230 2140 HOH A O   
6141 O  O   . HOH S .   ? 0.43210 0.55990 0.46820 0.00950  0.04260  0.13320  2141 HOH A O   
6142 O  O   . HOH S .   ? 0.12880 0.19920 0.21280 -0.00200 -0.00450 0.00530  2142 HOH A O   
6143 O  O   . HOH S .   ? 0.45120 0.18780 0.32850 -0.05050 0.00200  0.01290  2143 HOH A O   
6144 O  O   . HOH S .   ? 0.11890 0.13000 0.17380 -0.01870 0.00120  -0.01390 2144 HOH A O   
6145 O  O   . HOH S .   ? 0.11960 0.14460 0.18530 0.00050  0.01420  0.00400  2145 HOH A O   
6146 O  O   . HOH S .   ? 0.23590 0.32290 0.28740 0.05940  0.01170  -0.03770 2146 HOH A O   
6147 O  O   . HOH S .   ? 0.27220 0.38709 0.40849 0.13019  0.15419  0.10500  2147 HOH A O   
6148 O  O   . HOH S .   ? 0.20810 0.17960 0.20990 -0.00850 0.02060  0.00850  2148 HOH A O   
6149 O  O   . HOH S .   ? 0.22740 0.36660 0.34540 -0.03590 -0.04380 -0.00940 2149 HOH A O   
6150 O  O   . HOH S .   ? 0.39480 0.35640 0.63300 -0.05750 -0.03070 0.03320  2150 HOH A O   
6151 O  O   . HOH S .   ? 0.15720 0.12730 0.21870 0.02730  -0.02180 -0.00530 2151 HOH A O   
6152 O  O   . HOH S .   ? 0.18150 0.22700 0.41930 -0.00400 0.05420  0.02420  2152 HOH A O   
6153 O  O   . HOH S .   ? 0.24850 0.23310 0.27410 -0.04350 0.07300  0.04120  2153 HOH A O   
6154 O  O   . HOH S .   ? 0.11100 0.11840 0.24750 -0.00470 0.01340  0.01340  2154 HOH A O   
6155 O  O   . HOH S .   ? 0.46610 0.44970 0.47600 -0.08690 0.07700  0.10800  2155 HOH A O   
6156 O  O   . HOH S .   ? 0.22500 0.22510 0.37880 0.01000  0.01940  0.07260  2156 HOH A O   
6157 O  O   . HOH S .   ? 0.28720 0.32610 0.35330 0.00430  -0.09070 -0.13820 2157 HOH A O   
6158 O  O   . HOH S .   ? 0.22470 0.20790 0.41650 0.05030  -0.04040 0.08390  2158 HOH A O   
6159 O  O   . HOH S .   ? 0.16890 0.17270 0.23870 -0.00060 -0.02580 -0.01010 2159 HOH A O   
6160 O  O   . HOH S .   ? 0.33320 0.35330 0.41170 0.15480  0.01960  0.04500  2160 HOH A O   
6161 O  O   . HOH S .   ? 0.23770 0.28740 0.27400 -0.04480 0.05740  0.05580  2161 HOH A O   
6162 O  O   . HOH S .   ? 0.28810 0.16110 0.29030 -0.00900 0.01150  0.00780  2162 HOH A O   
6163 O  O   . HOH S .   ? 0.43940 0.51970 0.46100 0.07020  0.03900  -0.03380 2163 HOH A O   
6164 O  O   . HOH S .   ? 0.41480 0.61660 0.46410 -0.09280 0.01990  -0.01490 2164 HOH A O   
6165 O  O   . HOH S .   ? 0.36270 0.36180 0.55020 0.01870  -0.00490 -0.11620 2165 HOH A O   
6166 O  O   . HOH S .   ? 0.10880 0.12110 0.18620 -0.00270 -0.00720 0.01660  2166 HOH A O   
6167 O  O   . HOH S .   ? 0.39900 0.44690 0.36540 -0.08080 -0.15540 -0.05940 2167 HOH A O   
6168 O  O   . HOH S .   ? 0.20400 0.21080 0.27590 -0.01140 0.01450  0.05810  2168 HOH A O   
6169 O  O   . HOH S .   ? 0.23440 0.13720 0.21920 0.01410  0.01720  0.02050  2169 HOH A O   
6170 O  O   . HOH S .   ? 0.26800 0.29020 0.28570 0.00430  -0.05670 -0.00260 2170 HOH A O   
6171 O  O   . HOH S .   ? 0.22030 0.27630 0.28720 0.00410  0.03810  -0.01220 2171 HOH A O   
6172 O  O   . HOH S .   ? 0.31100 0.24080 0.47100 0.02860  0.16680  0.03390  2172 HOH A O   
6173 O  O   . HOH S .   ? 0.52380 0.51660 0.51010 0.04800  -0.13300 0.02000  2173 HOH A O   
6174 O  O   . HOH S .   ? 0.24310 0.27440 0.39920 0.06840  -0.00530 -0.01060 2174 HOH A O   
6175 O  O   . HOH S .   ? 0.16350 0.17620 0.33720 -0.03620 -0.01960 0.05860  2175 HOH A O   
6176 O  O   . HOH S .   ? 0.47630 0.29240 0.48340 -0.00410 0.11130  0.07410  2176 HOH A O   
6177 O  O   . HOH S .   ? 0.32160 0.46910 0.42290 -0.00190 0.08190  0.14220  2177 HOH A O   
6178 O  O   . HOH S .   ? 0.20010 0.22220 0.32690 -0.06490 0.06720  -0.06180 2178 HOH A O   
6179 O  O   . HOH S .   ? 0.43330 0.46870 0.42260 0.03460  0.00720  -0.00570 2179 HOH A O   
6180 O  O   . HOH S .   ? 0.18580 0.11650 0.31860 -0.02680 -0.00500 0.03820  2180 HOH A O   
6181 O  O   . HOH S .   ? 0.09450 0.14750 0.18560 -0.00210 0.00490  -0.00170 2181 HOH A O   
6182 O  O   . HOH S .   ? 0.38000 0.38010 0.38000 0.00010  -0.00000 0.00000  2182 HOH A O   
6183 O  O   . HOH S .   ? 0.11790 0.15810 0.20260 0.01900  -0.01220 -0.00460 2183 HOH A O   
6184 O  O   . HOH S .   ? 0.32830 0.39350 0.27570 0.02760  0.01350  -0.00450 2184 HOH A O   
6185 O  O   . HOH S .   ? 0.18480 0.16760 0.24420 0.03040  0.00010  0.00930  2185 HOH A O   
6186 O  O   . HOH S .   ? 0.26350 0.21850 0.33070 0.04600  0.02150  0.02290  2186 HOH A O   
6187 O  O   . HOH S .   ? 0.45070 0.23380 0.46020 -0.05220 0.08550  -0.02260 2187 HOH A O   
6188 O  O   . HOH S .   ? 0.31300 0.38380 0.36860 -0.00060 0.05390  0.10930  2188 HOH A O   
6189 O  O   . HOH S .   ? 0.54410 0.46170 0.54130 0.10210  0.02220  -0.02720 2189 HOH A O   
6190 O  O   . HOH S .   ? 0.29350 0.39090 0.41320 0.00380  0.01240  -0.04200 2190 HOH A O   
6191 O  O   . HOH S .   ? 0.11860 0.10310 0.17400 -0.00530 0.00930  0.00320  2191 HOH A O   
6192 O  O   . HOH S .   ? 0.40840 0.41560 0.48780 0.12590  -0.10660 -0.09730 2192 HOH A O   
6193 O  O   . HOH S .   ? 0.29950 0.27450 0.33480 -0.00710 0.03810  0.00470  2193 HOH A O   
6194 O  O   . HOH S .   ? 0.11870 0.14160 0.19490 -0.02980 -0.01400 0.02550  2194 HOH A O   
6195 O  O   . HOH S .   ? 0.16170 0.14680 0.22530 0.02600  -0.04160 -0.00850 2195 HOH A O   
6196 O  O   . HOH S .   ? 0.21670 0.20990 0.29550 0.04460  0.00340  -0.02350 2196 HOH A O   
6197 O  O   . HOH S .   ? 0.13602 0.20930 0.44888 0.02429  -0.06869 -0.00350 2197 HOH A O   
6198 O  O   . HOH S .   ? 0.21010 0.26720 0.38730 0.02840  0.07060  0.15140  2198 HOH A O   
6199 O  O   . HOH S .   ? 0.47210 0.54630 0.49940 0.11910  -0.05110 0.03240  2199 HOH A O   
6200 O  O   . HOH S .   ? 0.32300 0.24500 0.46650 0.00850  0.07540  -0.01430 2200 HOH A O   
6201 O  O   . HOH S .   ? 0.24310 0.37110 0.28500 0.03280  -0.04340 0.01460  2201 HOH A O   
6202 O  O   . HOH S .   ? 0.22610 0.31350 0.45280 0.03080  0.04440  -0.04390 2202 HOH A O   
6203 O  O   . HOH S .   ? 0.34550 0.34810 0.32770 0.08420  -0.00820 0.02000  2203 HOH A O   
6204 O  O   . HOH S .   ? 0.41940 0.32690 0.34020 0.07660  -0.00150 0.01890  2204 HOH A O   
6205 O  O   . HOH S .   ? 0.43680 0.29680 0.35440 0.07470  0.12500  0.02070  2205 HOH A O   
6206 O  O   . HOH S .   ? 0.24950 0.22230 0.25890 -0.04240 0.04030  0.02710  2206 HOH A O   
6207 O  O   . HOH S .   ? 0.08730 0.14390 0.18220 -0.00660 0.01490  -0.02920 2207 HOH A O   
6208 O  O   . HOH S .   ? 0.42100 0.24370 0.44520 0.03150  -0.00330 0.09070  2208 HOH A O   
6209 O  O   . HOH S .   ? 0.21750 0.20960 0.21410 -0.00310 0.04340  -0.00380 2209 HOH A O   
6210 O  O   . HOH S .   ? 0.32020 0.23180 0.51360 -0.08920 0.00850  0.04250  2210 HOH A O   
6211 O  O   . HOH S .   ? 0.15370 0.28760 0.22740 0.00890  -0.00870 -0.06590 2211 HOH A O   
6212 O  O   B HOH S .   ? 0.35030 0.32740 0.33270 0.00890  0.04610  -0.00240 2212 HOH A O   
6213 O  O   . HOH S .   ? 0.18450 0.15270 0.34420 0.01180  0.02500  0.02610  2213 HOH A O   
6214 O  O   . HOH S .   ? 0.39690 0.14830 0.27960 0.01610  -0.10760 -0.05220 2214 HOH A O   
6215 O  O   . HOH S .   ? 0.25250 0.40060 0.27140 0.04920  0.09610  -0.04800 2215 HOH A O   
6216 O  O   . HOH S .   ? 0.12380 0.13610 0.20140 0.01870  -0.02110 -0.00050 2216 HOH A O   
6217 O  O   . HOH S .   ? 0.20820 0.42740 0.43120 0.02370  -0.02940 -0.06170 2217 HOH A O   
6218 O  O   . HOH S .   ? 0.25250 0.36600 0.27130 -0.02320 0.03960  -0.02250 2218 HOH A O   
6219 O  O   . HOH S .   ? 0.24880 0.20900 0.21950 -0.04260 -0.00370 0.02740  2219 HOH A O   
6220 O  O   . HOH S .   ? 0.47660 0.66260 0.49860 0.03200  0.09140  -0.00250 2220 HOH A O   
6221 O  O   . HOH S .   ? 0.21960 0.42340 0.28360 -0.01450 -0.06350 -0.00220 2221 HOH A O   
6222 O  O   . HOH S .   ? 0.39160 0.48020 0.35670 -0.01300 0.13220  0.02710  2222 HOH A O   
6223 O  O   . HOH S .   ? 0.16880 0.18120 0.25690 -0.03910 0.04250  -0.04170 2223 HOH A O   
6224 O  O   . HOH S .   ? 0.30370 0.26580 0.41100 -0.01410 0.16370  0.02040  2224 HOH A O   
6225 O  O   . HOH S .   ? 0.17950 0.11850 0.23300 -0.02020 0.01190  -0.01060 2225 HOH A O   
6226 O  O   . HOH S .   ? 0.18210 0.22440 0.39610 -0.01830 0.08370  -0.01820 2226 HOH A O   
6227 O  O   . HOH S .   ? 0.62120 0.33670 0.43190 0.01430  -0.02450 -0.00400 2227 HOH A O   
6228 O  O   . HOH S .   ? 0.24470 0.21480 0.38570 0.07070  0.08560  0.06180  2228 HOH A O   
6229 O  O   . HOH S .   ? 0.39530 0.31090 0.43870 -0.15100 0.02410  0.02080  2229 HOH A O   
6230 O  O   . HOH S .   ? 0.24170 0.37310 0.36880 -0.04200 0.00790  -0.01780 2230 HOH A O   
6231 O  O   . HOH S .   ? 0.44050 0.29420 0.29900 -0.03460 -0.13790 -0.03710 2231 HOH A O   
6232 O  O   . HOH S .   ? 0.31160 0.28220 0.39170 -0.06950 0.10290  -0.06210 2232 HOH A O   
6233 O  O   . HOH S .   ? 0.21460 0.23580 0.33370 0.04390  0.12710  0.01350  2233 HOH A O   
6234 O  O   . HOH S .   ? 0.27860 0.31320 0.42480 0.07740  0.05860  -0.03690 2234 HOH A O   
6235 O  O   . HOH S .   ? 0.25690 0.26470 0.35790 -0.04930 -0.00040 -0.00410 2235 HOH A O   
6236 O  O   . HOH S .   ? 0.55500 0.53570 0.53280 0.04760  -0.03770 0.02930  2236 HOH A O   
6237 O  O   . HOH S .   ? 0.34430 0.36080 0.41800 0.04050  -0.00400 0.01790  2237 HOH A O   
6238 O  O   . HOH S .   ? 0.38010 0.32050 0.42130 -0.00200 -0.07710 0.02390  2238 HOH A O   
6239 O  O   . HOH S .   ? 0.23660 0.30580 0.24520 -0.06430 0.02890  0.03300  2239 HOH A O   
6240 O  O   . HOH S .   ? 0.33910 0.37530 0.39170 -0.02500 0.04560  0.03040  2240 HOH A O   
6241 O  O   . HOH S .   ? 0.43000 0.57060 0.44740 0.01740  -0.01310 -0.07530 2241 HOH A O   
6242 O  O   . HOH S .   ? 0.30420 0.21990 0.25030 -0.04750 -0.01490 -0.01660 2242 HOH A O   
6243 O  O   . HOH S .   ? 0.14580 0.14180 0.17580 0.01190  0.00220  -0.00680 2243 HOH A O   
6244 O  O   . HOH S .   ? 0.26650 0.37230 0.36300 -0.13060 -0.05160 -0.02840 2244 HOH A O   
6245 O  O   . HOH S .   ? 0.64030 0.53390 0.56640 0.03440  0.01650  -0.00940 2245 HOH A O   
6246 O  O   . HOH S .   ? 0.13040 0.13180 0.22570 0.00740  -0.01150 0.00770  2246 HOH A O   
6247 O  O   . HOH S .   ? 0.16710 0.28230 0.20620 -0.00320 0.05230  0.01370  2247 HOH A O   
6248 O  O   . HOH S .   ? 0.33280 0.42100 0.38750 -0.09900 0.07440  -0.10450 2248 HOH A O   
6249 O  O   . HOH S .   ? 0.19910 0.26410 0.41980 -0.03740 0.10910  -0.07030 2249 HOH A O   
6250 O  O   . HOH S .   ? 0.24680 0.44050 0.32100 -0.09050 0.02680  0.02760  2250 HOH A O   
6251 O  O   . HOH S .   ? 0.30020 0.32330 0.36800 -0.01250 0.10680  -0.13130 2251 HOH A O   
6252 O  O   . HOH S .   ? 0.31330 0.48190 0.40910 -0.07650 0.01130  -0.01250 2252 HOH A O   
6253 O  O   . HOH S .   ? 0.34180 0.45140 0.31970 0.00900  -0.03350 -0.01360 2253 HOH A O   
6254 O  O   . HOH S .   ? 0.09420 0.12960 0.19280 -0.00670 -0.01390 -0.00130 2254 HOH A O   
6255 O  O   . HOH S .   ? 0.35650 0.14240 0.32390 0.00330  0.13480  -0.02430 2255 HOH A O   
6256 O  O   . HOH S .   ? 0.51780 0.50650 0.49600 0.08210  0.08180  -0.06360 2256 HOH A O   
6257 O  O   . HOH S .   ? 0.22370 0.24590 0.39530 0.03350  -0.00470 -0.03900 2257 HOH A O   
6258 O  O   . HOH S .   ? 0.18360 0.24080 0.35090 0.03700  -0.09700 -0.05050 2258 HOH A O   
6259 O  O   . HOH S .   ? 0.57130 0.67450 0.64390 -0.00920 -0.03070 0.03670  2259 HOH A O   
6260 O  O   . HOH S .   ? 0.21040 0.26590 0.31640 -0.03930 0.03250  0.02890  2260 HOH A O   
6261 O  O   . HOH S .   ? 0.14840 0.12030 0.23830 0.03860  -0.01190 -0.01240 2261 HOH A O   
6262 O  O   . HOH S .   ? 0.26420 0.34070 0.21140 0.08910  -0.00980 -0.01290 2262 HOH A O   
6263 O  O   . HOH S .   ? 0.51030 0.51730 0.36090 0.00500  -0.03980 -0.15870 2263 HOH A O   
6264 O  O   . HOH S .   ? 0.33430 0.31760 0.32050 0.01900  -0.02870 -0.00300 2264 HOH A O   
6265 O  O   . HOH S .   ? 0.23580 0.26080 0.31280 0.00290  0.00180  -0.12200 2265 HOH A O   
6266 O  O   . HOH S .   ? 0.13380 0.11680 0.22680 0.00580  0.01760  0.00390  2266 HOH A O   
6267 O  O   . HOH S .   ? 0.18111 0.45557 0.28420 -0.05799 -0.07919 -0.05879 2267 HOH A O   
6268 O  O   . HOH S .   ? 0.43470 0.29500 0.40880 0.03930  0.12120  0.09660  2268 HOH A O   
6269 O  O   . HOH S .   ? 0.44350 0.50360 0.50870 -0.13770 0.00740  0.05090  2269 HOH A O   
6270 O  O   . HOH S .   ? 0.25360 0.34980 0.44060 -0.06420 -0.06120 -0.16530 2270 HOH A O   
6271 O  O   . HOH S .   ? 0.29070 0.20100 0.38010 0.02860  -0.08060 0.05250  2271 HOH A O   
6272 O  O   . HOH S .   ? 0.32860 0.26090 0.21120 -0.03350 -0.07880 -0.01440 2272 HOH A O   
6273 O  O   . HOH S .   ? 0.34050 0.38550 0.44790 -0.08050 -0.02090 -0.08580 2273 HOH A O   
6274 O  O   . HOH S .   ? 0.18030 0.21280 0.31890 -0.04090 0.03630  -0.06290 2274 HOH A O   
6275 O  O   . HOH S .   ? 0.26050 0.41860 0.26430 -0.11070 0.01690  0.04460  2275 HOH A O   
6276 O  O   . HOH S .   ? 0.25012 0.59257 0.36200 -0.09889 -0.12428 0.02430  2276 HOH A O   
6277 O  O   . HOH S .   ? 0.59400 0.47390 0.55920 0.08810  0.02330  0.04500  2277 HOH A O   
6278 O  O   . HOH S .   ? 0.21300 0.44220 0.39160 0.12040  -0.00960 0.04260  2278 HOH A O   
6279 O  O   . HOH S .   ? 0.32670 0.26760 0.30080 0.06500  -0.04810 -0.09860 2279 HOH A O   
6280 O  O   . HOH S .   ? 0.23620 0.41630 0.34130 -0.02220 0.12950  -0.02630 2280 HOH A O   
6281 O  O   . HOH S .   ? 0.15030 0.19500 0.37070 -0.03160 0.00890  -0.05040 2281 HOH A O   
6282 O  O   . HOH S .   ? 0.11480 0.10860 0.20100 -0.01650 0.00780  -0.00690 2282 HOH A O   
6283 O  O   . HOH S .   ? 0.16960 0.18690 0.27460 0.08000  -0.00000 -0.03960 2283 HOH A O   
6284 O  O   . HOH S .   ? 0.58030 0.48510 0.51150 -0.13500 -0.00480 0.02670  2284 HOH A O   
6285 O  O   . HOH S .   ? 0.39850 0.30060 0.30790 0.10930  -0.13590 -0.03570 2285 HOH A O   
6286 O  O   . HOH S .   ? 0.39630 0.40130 0.35200 -0.01660 -0.06880 0.09390  2286 HOH A O   
6287 O  O   . HOH S .   ? 0.54210 0.66080 0.63870 0.05240  -0.05410 -0.07440 2287 HOH A O   
6288 O  O   . HOH S .   ? 0.38870 0.30260 0.38599 0.18839  0.10009  0.04020  2288 HOH A O   
6289 O  O   . HOH S .   ? 0.63620 0.57620 0.55150 0.01730  -0.02810 0.03900  2289 HOH A O   
6290 O  O   . HOH S .   ? 0.20980 0.16920 0.26060 0.00030  0.01130  0.00460  2290 HOH A O   
6291 O  O   . HOH S .   ? 0.35140 0.23970 0.42680 -0.08680 0.04530  -0.04570 2291 HOH A O   
6292 O  O   . HOH S .   ? 0.44740 0.42430 0.57160 0.20100  0.08610  -0.05000 2292 HOH A O   
6293 O  O   . HOH S .   ? 0.33770 0.45430 0.48220 -0.00060 -0.00020 0.04990  2293 HOH A O   
6294 O  O   . HOH S .   ? 0.45460 0.35210 0.49880 0.03360  -0.05530 0.00510  2294 HOH A O   
6295 O  O   . HOH S .   ? 0.50640 0.41460 0.53800 -0.16900 0.02310  0.12980  2295 HOH A O   
6296 O  O   . HOH S .   ? 0.46730 0.34730 0.50680 -0.03320 -0.08990 0.03540  2296 HOH A O   
6297 O  O   . HOH S .   ? 0.42730 0.48590 0.40790 0.15800  -0.01340 0.05650  2297 HOH A O   
6298 O  O   . HOH S .   ? 0.40430 0.41890 0.52260 0.21460  0.03370  0.09640  2298 HOH A O   
6299 O  O   . HOH S .   ? 0.44300 0.47420 0.62900 -0.13000 -0.00580 0.00180  2299 HOH A O   
6300 O  O   . HOH S .   ? 0.46800 0.24100 0.33490 -0.17360 0.02000  0.02990  2300 HOH A O   
6301 O  O   . HOH S .   ? 0.45860 0.24860 0.44270 0.08130  0.01390  -0.01370 2301 HOH A O   
6302 O  O   . HOH S .   ? 0.44220 0.45570 0.33450 -0.04080 0.02770  0.03920  2302 HOH A O   
6303 O  O   . HOH S .   ? 0.52440 0.52150 0.39430 0.05050  0.12750  -0.04300 2303 HOH A O   
6304 O  O   . HOH S .   ? 0.50380 0.22500 0.50300 0.04130  0.20480  -0.06040 2304 HOH A O   
6305 O  O   . HOH S .   ? 0.43070 0.58150 0.50070 0.00810  0.08740  0.02890  2305 HOH A O   
6306 O  O   . HOH S .   ? 0.34490 0.58850 0.50320 -0.00540 -0.00280 0.15110  2306 HOH A O   
6307 O  O   . HOH S .   ? 0.36390 0.42560 0.49340 0.04160  0.02740  0.12020  2307 HOH A O   
6308 O  O   . HOH S .   ? 0.25570 0.24410 0.44330 -0.04250 -0.01220 0.00230  2308 HOH A O   
6309 O  O   . HOH S .   ? 0.41450 0.45770 0.39600 0.00510  0.02930  0.08330  2309 HOH A O   
6310 O  O   . HOH S .   ? 0.36990 0.59710 0.46800 0.10830  0.07520  0.00170  2310 HOH A O   
6311 O  O   . HOH S .   ? 0.53950 0.47450 0.50610 0.01380  -0.02150 0.04910  2311 HOH A O   
6312 O  O   . HOH S .   ? 0.33440 0.35810 0.34740 -0.02930 -0.07180 0.12450  2312 HOH A O   
6313 O  O   . HOH S .   ? 0.49210 0.20570 0.48620 0.06950  -0.03010 0.07710  2313 HOH A O   
6314 O  O   . HOH S .   ? 0.46470 0.47040 0.45350 -0.00500 -0.00490 -0.00860 2314 HOH A O   
6315 O  O   . HOH S .   ? 0.16110 0.18650 0.24310 -0.03780 0.02710  -0.00350 2315 HOH A O   
6316 O  O   . HOH S .   ? 0.21121 0.27430 0.52858 -0.06899 -0.01480 0.14789  2316 HOH A O   
6317 O  O   . HOH S .   ? 0.46170 0.46210 0.42740 -0.07060 -0.00780 0.01690  2317 HOH A O   
6318 O  O   . HOH S .   ? 0.36360 0.35430 0.49460 -0.04760 0.21040  -0.04420 2318 HOH A O   
6319 O  O   . HOH S .   ? 0.48430 0.65840 0.42670 -0.06630 -0.11160 0.15740  2319 HOH A O   
6320 O  O   . HOH S .   ? 0.43630 0.42190 0.45030 -0.06400 0.02860  -0.11000 2320 HOH A O   
6321 O  O   . HOH S .   ? 0.62550 0.23580 0.42520 -0.03990 0.05470  0.03660  2321 HOH A O   
6322 O  O   . HOH S .   ? 0.43680 0.55270 0.43220 0.01550  0.06720  0.13220  2322 HOH A O   
6323 O  O   . HOH S .   ? 0.34200 0.30410 0.44230 0.07650  0.13480  0.09550  2323 HOH A O   
6324 O  O   . HOH S .   ? 0.44960 0.43060 0.47240 0.07170  -0.01690 0.05580  2324 HOH A O   
6325 O  O   . HOH S .   ? 0.56700 0.54250 0.42210 0.01990  0.04800  -0.04890 2325 HOH A O   
6326 O  O   . HOH S .   ? 0.27640 0.24560 0.27780 0.02390  -0.00090 -0.01990 2326 HOH A O   
6327 O  O   . HOH S .   ? 0.23330 0.41320 0.40890 0.03750  -0.04970 -0.08820 2327 HOH A O   
6328 O  O   . HOH S .   ? 0.51930 0.53740 0.49610 0.01930  -0.03680 0.01960  2328 HOH A O   
6329 O  O   . HOH S .   ? 0.47430 0.40810 0.52770 -0.13060 0.13680  -0.09800 2329 HOH A O   
6330 O  O   . HOH S .   ? 0.45950 0.50870 0.49720 -0.02420 0.05590  0.01520  2330 HOH A O   
6331 O  O   . HOH S .   ? 0.53550 0.49680 0.48330 0.16820  0.01700  0.01820  2331 HOH A O   
6332 O  O   . HOH S .   ? 0.51340 0.51340 0.42900 -0.02180 -0.01780 -0.02010 2332 HOH A O   
6333 O  O   . HOH S .   ? 0.46830 0.32790 0.49430 0.18580  -0.09780 -0.07200 2333 HOH A O   
6334 O  O   . HOH S .   ? 0.46760 0.48850 0.42020 -0.06150 -0.00560 -0.05460 2334 HOH A O   
6335 O  O   . HOH S .   ? 0.28690 0.48420 0.41650 0.04030  -0.08090 0.09360  2335 HOH A O   
6336 O  O   . HOH S .   ? 0.44500 0.41380 0.41460 0.14280  -0.03360 -0.00820 2336 HOH A O   
6337 O  O   . HOH S .   ? 0.38480 0.40990 0.38790 0.01270  0.00600  -0.00040 2337 HOH A O   
6338 O  O   . HOH S .   ? 0.48230 0.38740 0.40660 -0.14220 0.03760  0.04430  2338 HOH A O   
6339 O  O   . HOH S .   ? 0.56010 0.49970 0.48850 0.05190  -0.01080 0.06050  2339 HOH A O   
6340 O  O   . HOH S .   ? 0.37860 0.56240 0.38520 0.24980  -0.06720 0.01280  2340 HOH A O   
6341 O  O   . HOH S .   ? 0.35190 0.52440 0.40270 0.02900  0.10600  0.05490  2341 HOH A O   
6342 O  O   . HOH S .   ? 0.53950 0.42920 0.40060 0.03510  -0.04090 0.05170  2342 HOH A O   
6343 O  O   . HOH S .   ? 0.41520 0.55220 0.47640 -0.01840 0.08050  -0.01430 2343 HOH A O   
6344 O  O   . HOH S .   ? 0.43120 0.30550 0.43890 0.05590  -0.01320 0.08930  2344 HOH A O   
6345 O  O   . HOH S .   ? 0.40560 0.55740 0.45060 -0.16040 -0.07200 0.01220  2345 HOH A O   
6346 O  O   . HOH S .   ? 0.40110 0.51060 0.51270 0.04620  0.03650  -0.03890 2346 HOH A O   
6347 O  O   . HOH S .   ? 0.49350 0.40820 0.42080 0.16530  0.07710  -0.00760 2347 HOH A O   
6348 O  O   . HOH S .   ? 0.18260 0.21670 0.24150 0.01060  -0.03090 -0.03440 2348 HOH A O   
6349 O  O   . HOH S .   ? 0.16760 0.18880 0.39430 0.02290  0.05210  -0.00200 2349 HOH A O   
6350 O  O   . HOH S .   ? 0.52420 0.40940 0.51300 -0.10790 -0.03570 0.08970  2350 HOH A O   
6351 O  O   . HOH S .   ? 0.50400 0.48980 0.46990 -0.00330 0.10630  0.05580  2351 HOH A O   
6352 O  O   . HOH S .   ? 0.52300 0.56550 0.50170 -0.10640 0.04020  -0.03900 2352 HOH A O   
6353 O  O   . HOH S .   ? 0.43610 0.49670 0.50500 -0.06030 -0.05860 -0.03890 2353 HOH A O   
6354 O  O   . HOH S .   ? 0.42240 0.41680 0.40900 -0.00060 -0.01900 0.00510  2354 HOH A O   
6355 O  O   . HOH S .   ? 0.55940 0.45380 0.47610 0.09730  0.07130  0.04340  2355 HOH A O   
6356 O  O   . HOH S .   ? 0.23060 0.34980 0.41340 0.06290  0.08340  -0.04760 2356 HOH A O   
6357 O  O   . HOH S .   ? 0.19940 0.23980 0.33060 0.00140  0.05470  0.05700  2357 HOH A O   
6358 O  O   . HOH S .   ? 0.40070 0.36690 0.54940 -0.00370 -0.03640 0.05070  2358 HOH A O   
6359 O  O   . HOH S .   ? 0.37840 0.37420 0.37110 -0.00230 0.02840  0.09530  2359 HOH A O   
6360 O  O   . HOH S .   ? 0.33540 0.41260 0.41090 -0.06550 -0.06000 -0.03140 2360 HOH A O   
6361 O  O   . HOH S .   ? 0.51060 0.52820 0.54880 0.01090  0.06100  0.02580  2361 HOH A O   
6362 O  O   . HOH S .   ? 0.35770 0.44950 0.38340 0.13580  -0.01590 0.03910  2362 HOH A O   
6363 O  O   . HOH S .   ? 0.32290 0.16940 0.47120 -0.03410 0.08490  -0.03720 2363 HOH A O   
6364 O  O   . HOH S .   ? 0.24610 0.31310 0.34290 -0.01280 -0.00360 -0.09890 2364 HOH A O   
6365 O  O   . HOH S .   ? 0.62200 0.48460 0.56850 0.00940  0.00990  0.01080  2365 HOH A O   
6366 O  O   . HOH S .   ? 0.10880 0.14170 0.19950 0.02790  -0.00090 0.04350  2366 HOH A O   
6367 O  O   . HOH S .   ? 0.46740 0.43540 0.49810 -0.05530 -0.02280 -0.10110 2367 HOH A O   
6368 O  O   . HOH S .   ? 0.29950 0.29890 0.42980 0.00630  0.04170  -0.00490 2368 HOH A O   
6369 O  O   . HOH S .   ? 0.34970 0.47250 0.37680 0.02160  -0.17230 0.07220  2369 HOH A O   
6370 O  O   . HOH S .   ? 0.38670 0.22870 0.34370 -0.10640 0.13590  -0.05160 2370 HOH A O   
6371 O  O   . HOH S .   ? 0.48070 0.54520 0.42130 0.10520  0.05800  0.01180  2371 HOH A O   
6372 O  O   . HOH S .   ? 0.20490 0.35540 0.25940 0.02450  0.05020  0.09430  2372 HOH A O   
6373 O  O   . HOH S .   ? 0.38730 0.40460 0.42030 -0.03640 0.00340  0.19560  2373 HOH A O   
6374 O  O   . HOH S .   ? 0.12410 0.15730 0.23860 -0.01110 -0.03330 -0.01140 2374 HOH A O   
6375 O  O   . HOH S .   ? 0.34980 0.43300 0.50270 -0.10740 -0.01230 -0.02590 2375 HOH A O   
6376 O  O   . HOH S .   ? 0.27690 0.42570 0.45300 -0.07920 -0.11180 0.08090  2376 HOH A O   
6377 O  O   . HOH S .   ? 0.49740 0.50650 0.55210 -0.05570 0.01360  -0.09350 2377 HOH A O   
6378 O  O   . HOH S .   ? 0.51490 0.39510 0.44730 -0.08970 0.05300  -0.02880 2378 HOH A O   
6379 O  O   . HOH S .   ? 0.51690 0.56520 0.57980 -0.06760 0.03780  0.10090  2379 HOH A O   
6380 O  O   . HOH S .   ? 0.48980 0.50810 0.50380 0.08870  -0.01670 0.12160  2380 HOH A O   
6381 O  O   . HOH S .   ? 0.31480 0.53060 0.43510 -0.11570 0.00690  0.07330  2381 HOH A O   
6382 O  O   . HOH S .   ? 0.56540 0.47380 0.52190 0.03160  0.00820  -0.05630 2382 HOH A O   
6383 O  O   . HOH S .   ? 0.27720 0.33870 0.31730 -0.03090 -0.05050 0.03430  2383 HOH A O   
6384 O  O   . HOH S .   ? 0.50660 0.59310 0.57350 -0.04090 -0.03470 0.10980  2384 HOH A O   
6385 O  O   . HOH S .   ? 0.29890 0.40510 0.43730 0.01590  0.00070  0.07520  2385 HOH A O   
6386 O  O   . HOH S .   ? 0.22220 0.20710 0.33600 -0.02480 0.02780  0.02940  2386 HOH A O   
6387 O  O   . HOH S .   ? 0.50720 0.47060 0.53320 0.09220  0.09800  -0.00540 2387 HOH A O   
6388 O  O   . HOH S .   ? 0.50130 0.30530 0.42180 -0.01980 0.02690  -0.02350 2388 HOH A O   
6389 O  O   . HOH S .   ? 0.44510 0.49620 0.48800 -0.03040 -0.09850 -0.01200 2389 HOH A O   
6390 O  O   . HOH S .   ? 0.39010 0.35340 0.50100 -0.04660 0.08530  0.02330  2390 HOH A O   
6391 O  O   . HOH S .   ? 0.58350 0.51470 0.43200 0.03930  -0.02020 0.08220  2391 HOH A O   
6392 O  O   . HOH S .   ? 0.55460 0.51290 0.53750 -0.00730 -0.09840 0.00590  2392 HOH A O   
6393 O  O   . HOH S .   ? 0.43920 0.48130 0.46730 0.02050  0.01040  -0.00430 2393 HOH A O   
6394 O  O   . HOH S .   ? 0.45850 0.49020 0.44300 0.10800  -0.00210 0.05130  2394 HOH A O   
6395 O  O   . HOH S .   ? 0.45850 0.44480 0.48490 -0.04790 -0.07970 -0.03700 2395 HOH A O   
6396 O  O   . HOH S .   ? 0.49940 0.44260 0.43200 0.05490  -0.05330 -0.07440 2396 HOH A O   
6397 O  O   . HOH S .   ? 0.17100 0.28610 0.34040 0.01910  0.03330  -0.00390 2397 HOH A O   
6398 O  O   . HOH S .   ? 0.51070 0.60420 0.48360 0.04440  -0.11040 0.06720  2398 HOH A O   
6399 O  O   . HOH S .   ? 0.55380 0.58780 0.48000 0.06350  0.01440  -0.02220 2399 HOH A O   
6400 O  O   . HOH S .   ? 0.16470 0.27990 0.26610 0.00000  0.01990  -0.00000 2400 HOH A O   
6401 O  O   . HOH S .   ? 0.42190 0.40900 0.37210 -0.11490 -0.00360 -0.13950 2401 HOH A O   
6402 O  O   . HOH S .   ? 0.39920 0.39660 0.42770 0.01530  -0.03480 -0.07690 2402 HOH A O   
6403 O  O   . HOH S .   ? 0.49530 0.50190 0.44510 0.03020  -0.07500 0.04970  2403 HOH A O   
6404 O  O   . HOH S .   ? 0.25600 0.30600 0.46440 0.00770  0.05690  0.01370  2404 HOH A O   
6405 O  O   . HOH S .   ? 0.46230 0.41300 0.56120 0.08610  -0.04200 -0.01270 2405 HOH A O   
6406 O  O   . HOH S .   ? 0.47440 0.53220 0.56440 -0.06010 -0.05090 -0.01540 2406 HOH A O   
6407 O  O   . HOH S .   ? 0.46610 0.52510 0.56480 0.05910  0.00520  0.02380  2407 HOH A O   
6408 O  O   . HOH S .   ? 0.33450 0.28510 0.26580 -0.16090 -0.08960 0.08380  2408 HOH A O   
6409 O  O   . HOH S .   ? 0.65070 0.58010 0.55060 0.03270  -0.04240 0.07650  2409 HOH A O   
6410 O  O   . HOH S .   ? 0.40010 0.50750 0.47980 0.03130  -0.02500 0.05640  2410 HOH A O   
6411 O  O   . HOH S .   ? 0.37150 0.57220 0.46380 0.08220  -0.07320 -0.02070 2411 HOH A O   
6412 O  O   . HOH S .   ? 0.51800 0.54360 0.54690 0.05820  0.06960  0.02520  2412 HOH A O   
6413 O  O   . HOH S .   ? 0.65430 0.47720 0.48970 -0.08070 -0.01370 0.03900  2413 HOH A O   
6414 O  O   . HOH S .   ? 0.51250 0.44220 0.56590 -0.02330 -0.05840 -0.00370 2414 HOH A O   
6415 O  O   . HOH S .   ? 0.39110 0.40140 0.28860 -0.18120 0.00230  0.07110  2415 HOH A O   
6416 O  O   . HOH S .   ? 0.51350 0.50200 0.46980 -0.10240 -0.06000 0.05830  2416 HOH A O   
6417 O  O   . HOH S .   ? 0.49810 0.43200 0.51400 0.06220  0.13690  0.10900  2417 HOH A O   
6418 O  O   . HOH S .   ? 0.56380 0.48180 0.50770 0.03540  0.01660  0.00040  2418 HOH A O   
6419 O  O   . HOH S .   ? 0.54580 0.45990 0.55210 -0.00600 0.05310  0.11080  2419 HOH A O   
6420 O  O   . HOH S .   ? 0.53820 0.48750 0.53570 0.00570  0.15280  0.05270  2420 HOH A O   
6421 O  O   . HOH S .   ? 0.54500 0.51200 0.49530 -0.04120 0.06400  -0.06070 2421 HOH A O   
6422 O  O   . HOH S .   ? 0.26200 0.46230 0.56580 -0.04360 -0.01740 -0.13630 2422 HOH A O   
6423 O  O   . HOH S .   ? 0.36120 0.34710 0.51730 -0.08280 0.01440  -0.00040 2423 HOH A O   
6424 O  O   . HOH S .   ? 0.31470 0.44920 0.29870 0.02960  -0.03160 -0.00520 2424 HOH A O   
6425 O  O   . HOH S .   ? 0.47900 0.44550 0.41430 0.00820  -0.12480 0.06760  2425 HOH A O   
6426 O  O   . HOH S .   ? 0.35720 0.36610 0.40130 -0.10210 -0.00870 -0.04190 2426 HOH A O   
6427 O  O   . HOH S .   ? 0.58860 0.58780 0.65620 0.12450  -0.03120 0.05240  2427 HOH A O   
6428 O  O   . HOH S .   ? 0.62460 0.49870 0.58030 -0.03890 0.02490  -0.04210 2428 HOH A O   
6429 O  O   . HOH S .   ? 0.32890 0.29580 0.40550 0.10160  -0.00430 0.10440  2429 HOH A O   
6430 O  O   . HOH S .   ? 0.44790 0.42400 0.42740 0.02800  0.01930  -0.05140 2430 HOH A O   
6431 O  O   . HOH S .   ? 0.49210 0.44430 0.42740 0.07110  -0.03450 -0.07100 2431 HOH A O   
6432 O  O   . HOH S .   ? 0.39730 0.29870 0.38440 0.00000  0.00780  -0.00000 2432 HOH A O   
6433 O  O   . HOH S .   ? 0.27020 0.31010 0.38730 -0.09090 0.11870  -0.04150 2433 HOH A O   
6434 O  O   . HOH S .   ? 0.56020 0.41520 0.43280 -0.03000 0.06610  0.03490  2434 HOH A O   
6435 O  O   . HOH S .   ? 0.40630 0.50050 0.50280 -0.16750 -0.04300 -0.00450 2435 HOH A O   
6436 O  O   . HOH S .   ? 0.26750 0.26510 0.35250 0.06080  -0.06450 -0.01960 2436 HOH A O   
6437 O  O   . HOH S .   ? 0.40070 0.31240 0.41740 0.04710  -0.03150 0.02870  2437 HOH A O   
6438 O  O   . HOH S .   ? 0.41690 0.53890 0.38780 0.05240  -0.03540 -0.15140 2438 HOH A O   
6439 O  O   . HOH S .   ? 0.42660 0.43480 0.45310 -0.06160 -0.01720 0.01540  2439 HOH A O   
6440 O  O   . HOH S .   ? 0.47550 0.50610 0.44780 -0.01920 0.03820  0.01800  2440 HOH A O   
6441 O  O   . HOH S .   ? 0.43220 0.47860 0.51370 0.00820  0.05480  0.08170  2441 HOH A O   
6442 O  O   . HOH S .   ? 0.59330 0.56260 0.53940 -0.01740 -0.04160 0.01500  2442 HOH A O   
6443 O  O   . HOH S .   ? 0.21360 0.30260 0.28170 -0.01410 0.01530  -0.03170 2443 HOH A O   
6444 O  O   . HOH S .   ? 0.41230 0.58930 0.46330 0.02150  -0.07250 -0.01480 2444 HOH A O   
6445 O  O   . HOH S .   ? 0.19640 0.24650 0.46480 0.00360  0.00520  0.02170  2445 HOH A O   
6446 O  O   . HOH S .   ? 0.34120 0.45580 0.50910 -0.00970 -0.07060 0.02600  2446 HOH A O   
6447 O  O   . HOH S .   ? 0.61420 0.36260 0.45970 0.12650  0.03590  0.00750  2447 HOH A O   
6448 O  O   . HOH S .   ? 0.46240 0.44670 0.44010 0.06460  -0.11280 0.05120  2448 HOH A O   
6449 O  O   . HOH S .   ? 0.32120 0.33690 0.30650 0.15990  0.00700  -0.03330 2449 HOH A O   
6450 O  O   . HOH S .   ? 0.32330 0.31180 0.29400 -0.06320 -0.03890 -0.02880 2450 HOH A O   
6451 O  O   . HOH S .   ? 0.16210 0.16590 0.32940 -0.02850 0.02370  -0.01780 2451 HOH A O   
6452 O  O   . HOH S .   ? 0.27580 0.60440 0.41880 0.15460  0.11640  0.00810  2452 HOH A O   
6453 O  O   . HOH S .   ? 0.31290 0.50400 0.47640 -0.00200 -0.03230 0.07110  2453 HOH A O   
6454 O  O   . HOH S .   ? 0.37770 0.45080 0.29870 0.04420  0.08420  -0.04210 2454 HOH A O   
6455 O  O   . HOH S .   ? 0.63090 0.47100 0.52580 0.00760  -0.03560 0.01060  2455 HOH A O   
6456 O  O   . HOH S .   ? 0.36370 0.42560 0.50940 0.10630  0.03210  0.06430  2456 HOH A O   
6457 O  O   . HOH S .   ? 0.18180 0.19120 0.46580 -0.01430 0.04740  -0.01270 2457 HOH A O   
6458 O  O   . HOH S .   ? 0.61100 0.55370 0.61050 -0.01900 0.07240  0.01690  2458 HOH A O   
6459 O  O   . HOH S .   ? 0.42450 0.21060 0.46020 -0.00770 -0.13720 -0.07830 2459 HOH A O   
6460 O  O   . HOH S .   ? 0.24090 0.37290 0.45380 -0.01790 0.00530  0.07900  2460 HOH A O   
6461 O  O   . HOH S .   ? 0.42800 0.35381 0.52269 -0.14068 0.20447  0.02110  2461 HOH A O   
6462 O  O   . HOH S .   ? 0.44380 0.48580 0.53590 0.00000  0.00310  -0.00000 2462 HOH A O   
6463 O  O   . HOH S .   ? 0.62490 0.59560 0.57750 -0.07690 -0.04160 -0.10850 2463 HOH A O   
6464 O  O   . HOH S .   ? 0.41310 0.28480 0.34720 0.05310  0.05070  0.04160  2464 HOH A O   
6465 O  O   . HOH S .   ? 0.38690 0.28580 0.51310 -0.11140 0.02820  0.02540  2465 HOH A O   
6466 O  O   . HOH S .   ? 0.59570 0.53540 0.55630 0.01390  -0.06540 -0.04040 2466 HOH A O   
6467 O  O   . HOH S .   ? 0.36350 0.42660 0.44110 0.00560  0.02800  -0.11090 2467 HOH A O   
6468 O  O   . HOH S .   ? 0.42880 0.34030 0.52020 0.01820  -0.05820 -0.09380 2468 HOH A O   
6469 O  O   . HOH S .   ? 0.31440 0.46490 0.46040 -0.00770 0.00300  -0.10160 2469 HOH A O   
6470 O  O   . HOH S .   ? 0.60700 0.46060 0.37870 -0.13400 0.00350  0.09140  2470 HOH A O   
6471 O  O   . HOH S .   ? 0.55670 0.45810 0.57090 -0.06100 -0.06710 -0.03330 2471 HOH A O   
6472 O  O   . HOH S .   ? 0.30450 0.20580 0.35280 0.02530  0.04740  0.05210  2472 HOH A O   
6473 O  O   . HOH S .   ? 0.55050 0.43860 0.51850 0.00150  0.02170  0.01880  2473 HOH A O   
6474 O  O   . HOH S .   ? 0.36080 0.24790 0.29190 0.00470  -0.05410 -0.01220 2474 HOH A O   
6475 O  O   . HOH S .   ? 0.61440 0.50320 0.44770 0.16440  0.06160  0.00100  2475 HOH A O   
6476 O  O   . HOH S .   ? 0.50740 0.27770 0.49650 -0.12600 0.06400  0.01240  2476 HOH A O   
6477 O  O   . HOH S .   ? 0.39740 0.37400 0.37590 0.00170  0.00230  -0.08130 2477 HOH A O   
6478 O  O   . HOH S .   ? 0.59740 0.41610 0.48790 0.03130  -0.09200 0.01480  2478 HOH A O   
6479 O  O   . HOH S .   ? 0.34280 0.25500 0.50810 -0.07450 -0.02260 0.03160  2479 HOH A O   
6480 O  O   . HOH S .   ? 0.30020 0.48850 0.53810 0.02150  -0.02430 -0.06710 2480 HOH A O   
6481 O  O   . HOH S .   ? 0.33810 0.48900 0.55150 0.01340  0.09020  -0.04950 2481 HOH A O   
6482 O  O   . HOH S .   ? 0.48350 0.49080 0.43100 -0.02180 -0.02550 0.02850  2482 HOH A O   
6483 O  O   . HOH S .   ? 0.45130 0.39330 0.44600 -0.12980 0.03840  -0.04030 2483 HOH A O   
6484 O  O   . HOH S .   ? 0.37590 0.46910 0.44830 -0.05120 -0.07790 -0.17560 2484 HOH A O   
6485 O  O   . HOH S .   ? 0.55480 0.35520 0.49970 -0.00960 -0.07760 0.07590  2485 HOH A O   
6486 O  O   . HOH S .   ? 0.36000 0.28920 0.29040 -0.13830 -0.01930 0.04130  2486 HOH A O   
6487 O  O   . HOH S .   ? 0.51300 0.54720 0.45500 0.05560  0.05210  -0.01110 2487 HOH A O   
6488 O  O   . HOH S .   ? 0.45440 0.36330 0.36000 -0.01800 0.08550  0.00290  2488 HOH A O   
6489 O  O   . HOH S .   ? 0.49590 0.44000 0.43880 0.00330  0.00150  0.06210  2489 HOH A O   
6490 O  O   . HOH S .   ? 0.43950 0.40520 0.46050 -0.00340 0.10650  0.04420  2490 HOH A O   
6491 O  O   . HOH S .   ? 0.46550 0.39020 0.49460 -0.08880 0.07510  -0.04100 2491 HOH A O   
6492 O  O   . HOH S .   ? 0.60200 0.66340 0.59560 -0.00610 -0.11480 -0.04530 2492 HOH A O   
6493 O  O   . HOH S .   ? 0.47420 0.40010 0.51030 0.02900  0.00840  -0.08540 2493 HOH A O   
6494 O  O   . HOH S .   ? 0.31640 0.54520 0.48920 -0.05750 -0.02810 0.04200  2494 HOH A O   
6495 O  O   . HOH S .   ? 0.45930 0.38420 0.53920 0.00000  0.03570  -0.00000 2495 HOH A O   
6496 O  O   . HOH S .   ? 0.46490 0.43130 0.44450 0.02440  -0.02280 0.02990  2496 HOH A O   
6497 O  O   . HOH S .   ? 0.31050 0.36910 0.46970 0.01880  0.00960  -0.12780 2497 HOH A O   
6498 O  O   . HOH S .   ? 0.62860 0.55480 0.52790 -0.06430 0.08430  0.08020  2498 HOH A O   
6499 O  O   . HOH S .   ? 0.43250 0.51340 0.47740 -0.17280 -0.10850 -0.02190 2499 HOH A O   
6500 O  O   . HOH S .   ? 0.54740 0.54310 0.47250 0.00190  0.04350  -0.08420 2500 HOH A O   
6501 O  O   . HOH S .   ? 0.36880 0.28270 0.38030 0.02320  0.05950  -0.05070 2501 HOH A O   
6502 O  O   . HOH S .   ? 0.48440 0.45350 0.48640 -0.05470 0.12110  0.02840  2502 HOH A O   
6503 O  O   . HOH S .   ? 0.55680 0.49890 0.63450 -0.05230 0.00510  0.01280  2503 HOH A O   
6504 O  O   . HOH S .   ? 0.45890 0.37590 0.45220 -0.10350 0.16660  -0.06730 2504 HOH A O   
# 
