data_9FMO
# 
_entry.id   9FMO 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FMO         pdb_00009fmo 10.2210/pdb9fmo/pdb 
WWPDB D_1292138938 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FMO 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              loll@chemie.fu-berlin.de 
_pdbx_contact_author.name_first         Bernhard 
_pdbx_contact_author.name_last          Loll 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7928-4488 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Dimos-Roehl, B.' 1 0009-0001-9034-5365 
'Haltenhof, T.'   2 ?                   
'Kotte, A.'       3 ?                   
'Heyd, F.'        4 ?                   
'Loll, B.'        5 0000-0001-7928-4488 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'to be published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of C. merolae LAMMER-like dual specificity kinase CmLIK kinase domain' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Dimos-Roehl, B.' 1 0009-0001-9034-5365 
primary 'Haltenhof, T.'   2 ?                   
primary 'Kotte, A.'       3 ?                   
primary 'Heyd, F.'        4 ?                   
primary 'Loll, B.'        5 0000-0001-7928-4488 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'LAMMER-like dual specificity kinase' 42887.359 1  ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL                        62.068    1  ? ? ? ? 
3 non-polymer nat 'ZINC ION'                            65.409    1  ? ? ? ? 
4 water       nat water                                 18.015    13 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPLGSPEFHVQYSVGEGLGPTADFPNGRYQILAPLGSGTFGKVVSCWDRVTEQLVAVKVIRAVRKYAEAARMEIDILLEL
GRKDPTSRFHCVRMLSYFTHVSQQGNAHVCLVFEHLGPSLFDVLMRNHFRPLPVPILRAVARQLLEAITFLHEHNQIVHT
DIKPENVLIVPSSYYPNRQITEHVQVRLIDFGSASRLDKVSVRHAIVSTRHYRAPEIILGTGWSFACDIWSFGALLVECY
TGQTLFQSHDDLEHLQLMQKLLQHENGEVIVPPPRPSPSSTSMGSQRRREALKLFRDGRLNWPEGIDEQSANSLARQKSI
RRVARMPELHSIFRPEHACLLHLIRCCLTIDPLKRWRPSELLRHPFFMSYSTEATP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPLGSPEFHVQYSVGEGLGPTADFPNGRYQILAPLGSGTFGKVVSCWDRVTEQLVAVKVIRAVRKYAEAARMEIDILLEL
GRKDPTSRFHCVRMLSYFTHVSQQGNAHVCLVFEHLGPSLFDVLMRNHFRPLPVPILRAVARQLLEAITFLHEHNQIVHT
DIKPENVLIVPSSYYPNRQITEHVQVRLIDFGSASRLDKVSVRHAIVSTRHYRAPEIILGTGWSFACDIWSFGALLVECY
TGQTLFQSHDDLEHLQLMQKLLQHENGEVIVPPPRPSPSSTSMGSQRRREALKLFRDGRLNWPEGIDEQSANSLARQKSI
RRVARMPELHSIFRPEHACLLHLIRCCLTIDPLKRWRPSELLRHPFFMSYSTEATP
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL EDO 
3 'ZINC ION'     ZN  
4 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   LEU n 
1 4   GLY n 
1 5   SER n 
1 6   PRO n 
1 7   GLU n 
1 8   PHE n 
1 9   HIS n 
1 10  VAL n 
1 11  GLN n 
1 12  TYR n 
1 13  SER n 
1 14  VAL n 
1 15  GLY n 
1 16  GLU n 
1 17  GLY n 
1 18  LEU n 
1 19  GLY n 
1 20  PRO n 
1 21  THR n 
1 22  ALA n 
1 23  ASP n 
1 24  PHE n 
1 25  PRO n 
1 26  ASN n 
1 27  GLY n 
1 28  ARG n 
1 29  TYR n 
1 30  GLN n 
1 31  ILE n 
1 32  LEU n 
1 33  ALA n 
1 34  PRO n 
1 35  LEU n 
1 36  GLY n 
1 37  SER n 
1 38  GLY n 
1 39  THR n 
1 40  PHE n 
1 41  GLY n 
1 42  LYS n 
1 43  VAL n 
1 44  VAL n 
1 45  SER n 
1 46  CYS n 
1 47  TRP n 
1 48  ASP n 
1 49  ARG n 
1 50  VAL n 
1 51  THR n 
1 52  GLU n 
1 53  GLN n 
1 54  LEU n 
1 55  VAL n 
1 56  ALA n 
1 57  VAL n 
1 58  LYS n 
1 59  VAL n 
1 60  ILE n 
1 61  ARG n 
1 62  ALA n 
1 63  VAL n 
1 64  ARG n 
1 65  LYS n 
1 66  TYR n 
1 67  ALA n 
1 68  GLU n 
1 69  ALA n 
1 70  ALA n 
1 71  ARG n 
1 72  MET n 
1 73  GLU n 
1 74  ILE n 
1 75  ASP n 
1 76  ILE n 
1 77  LEU n 
1 78  LEU n 
1 79  GLU n 
1 80  LEU n 
1 81  GLY n 
1 82  ARG n 
1 83  LYS n 
1 84  ASP n 
1 85  PRO n 
1 86  THR n 
1 87  SER n 
1 88  ARG n 
1 89  PHE n 
1 90  HIS n 
1 91  CYS n 
1 92  VAL n 
1 93  ARG n 
1 94  MET n 
1 95  LEU n 
1 96  SER n 
1 97  TYR n 
1 98  PHE n 
1 99  THR n 
1 100 HIS n 
1 101 VAL n 
1 102 SER n 
1 103 GLN n 
1 104 GLN n 
1 105 GLY n 
1 106 ASN n 
1 107 ALA n 
1 108 HIS n 
1 109 VAL n 
1 110 CYS n 
1 111 LEU n 
1 112 VAL n 
1 113 PHE n 
1 114 GLU n 
1 115 HIS n 
1 116 LEU n 
1 117 GLY n 
1 118 PRO n 
1 119 SER n 
1 120 LEU n 
1 121 PHE n 
1 122 ASP n 
1 123 VAL n 
1 124 LEU n 
1 125 MET n 
1 126 ARG n 
1 127 ASN n 
1 128 HIS n 
1 129 PHE n 
1 130 ARG n 
1 131 PRO n 
1 132 LEU n 
1 133 PRO n 
1 134 VAL n 
1 135 PRO n 
1 136 ILE n 
1 137 LEU n 
1 138 ARG n 
1 139 ALA n 
1 140 VAL n 
1 141 ALA n 
1 142 ARG n 
1 143 GLN n 
1 144 LEU n 
1 145 LEU n 
1 146 GLU n 
1 147 ALA n 
1 148 ILE n 
1 149 THR n 
1 150 PHE n 
1 151 LEU n 
1 152 HIS n 
1 153 GLU n 
1 154 HIS n 
1 155 ASN n 
1 156 GLN n 
1 157 ILE n 
1 158 VAL n 
1 159 HIS n 
1 160 THR n 
1 161 ASP n 
1 162 ILE n 
1 163 LYS n 
1 164 PRO n 
1 165 GLU n 
1 166 ASN n 
1 167 VAL n 
1 168 LEU n 
1 169 ILE n 
1 170 VAL n 
1 171 PRO n 
1 172 SER n 
1 173 SER n 
1 174 TYR n 
1 175 TYR n 
1 176 PRO n 
1 177 ASN n 
1 178 ARG n 
1 179 GLN n 
1 180 ILE n 
1 181 THR n 
1 182 GLU n 
1 183 HIS n 
1 184 VAL n 
1 185 GLN n 
1 186 VAL n 
1 187 ARG n 
1 188 LEU n 
1 189 ILE n 
1 190 ASP n 
1 191 PHE n 
1 192 GLY n 
1 193 SER n 
1 194 ALA n 
1 195 SER n 
1 196 ARG n 
1 197 LEU n 
1 198 ASP n 
1 199 LYS n 
1 200 VAL n 
1 201 SER n 
1 202 VAL n 
1 203 ARG n 
1 204 HIS n 
1 205 ALA n 
1 206 ILE n 
1 207 VAL n 
1 208 SER n 
1 209 THR n 
1 210 ARG n 
1 211 HIS n 
1 212 TYR n 
1 213 ARG n 
1 214 ALA n 
1 215 PRO n 
1 216 GLU n 
1 217 ILE n 
1 218 ILE n 
1 219 LEU n 
1 220 GLY n 
1 221 THR n 
1 222 GLY n 
1 223 TRP n 
1 224 SER n 
1 225 PHE n 
1 226 ALA n 
1 227 CYS n 
1 228 ASP n 
1 229 ILE n 
1 230 TRP n 
1 231 SER n 
1 232 PHE n 
1 233 GLY n 
1 234 ALA n 
1 235 LEU n 
1 236 LEU n 
1 237 VAL n 
1 238 GLU n 
1 239 CYS n 
1 240 TYR n 
1 241 THR n 
1 242 GLY n 
1 243 GLN n 
1 244 THR n 
1 245 LEU n 
1 246 PHE n 
1 247 GLN n 
1 248 SER n 
1 249 HIS n 
1 250 ASP n 
1 251 ASP n 
1 252 LEU n 
1 253 GLU n 
1 254 HIS n 
1 255 LEU n 
1 256 GLN n 
1 257 LEU n 
1 258 MET n 
1 259 GLN n 
1 260 LYS n 
1 261 LEU n 
1 262 LEU n 
1 263 GLN n 
1 264 HIS n 
1 265 GLU n 
1 266 ASN n 
1 267 GLY n 
1 268 GLU n 
1 269 VAL n 
1 270 ILE n 
1 271 VAL n 
1 272 PRO n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 PRO n 
1 277 SER n 
1 278 PRO n 
1 279 SER n 
1 280 SER n 
1 281 THR n 
1 282 SER n 
1 283 MET n 
1 284 GLY n 
1 285 SER n 
1 286 GLN n 
1 287 ARG n 
1 288 ARG n 
1 289 ARG n 
1 290 GLU n 
1 291 ALA n 
1 292 LEU n 
1 293 LYS n 
1 294 LEU n 
1 295 PHE n 
1 296 ARG n 
1 297 ASP n 
1 298 GLY n 
1 299 ARG n 
1 300 LEU n 
1 301 ASN n 
1 302 TRP n 
1 303 PRO n 
1 304 GLU n 
1 305 GLY n 
1 306 ILE n 
1 307 ASP n 
1 308 GLU n 
1 309 GLN n 
1 310 SER n 
1 311 ALA n 
1 312 ASN n 
1 313 SER n 
1 314 LEU n 
1 315 ALA n 
1 316 ARG n 
1 317 GLN n 
1 318 LYS n 
1 319 SER n 
1 320 ILE n 
1 321 ARG n 
1 322 ARG n 
1 323 VAL n 
1 324 ALA n 
1 325 ARG n 
1 326 MET n 
1 327 PRO n 
1 328 GLU n 
1 329 LEU n 
1 330 HIS n 
1 331 SER n 
1 332 ILE n 
1 333 PHE n 
1 334 ARG n 
1 335 PRO n 
1 336 GLU n 
1 337 HIS n 
1 338 ALA n 
1 339 CYS n 
1 340 LEU n 
1 341 LEU n 
1 342 HIS n 
1 343 LEU n 
1 344 ILE n 
1 345 ARG n 
1 346 CYS n 
1 347 CYS n 
1 348 LEU n 
1 349 THR n 
1 350 ILE n 
1 351 ASP n 
1 352 PRO n 
1 353 LEU n 
1 354 LYS n 
1 355 ARG n 
1 356 TRP n 
1 357 ARG n 
1 358 PRO n 
1 359 SER n 
1 360 GLU n 
1 361 LEU n 
1 362 LEU n 
1 363 ARG n 
1 364 HIS n 
1 365 PRO n 
1 366 PHE n 
1 367 PHE n 
1 368 MET n 
1 369 SER n 
1 370 TYR n 
1 371 SER n 
1 372 THR n 
1 373 GLU n 
1 374 ALA n 
1 375 THR n 
1 376 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   376 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CYME_CMR245C 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Cyanidioschyzon merolae' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     45157 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pGEX-6P 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ?                 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   440 ?   ?   ?   A . n 
A 1 2   PRO 2   441 ?   ?   ?   A . n 
A 1 3   LEU 3   442 ?   ?   ?   A . n 
A 1 4   GLY 4   443 ?   ?   ?   A . n 
A 1 5   SER 5   444 ?   ?   ?   A . n 
A 1 6   PRO 6   445 ?   ?   ?   A . n 
A 1 7   GLU 7   446 446 GLU GLU A . n 
A 1 8   PHE 8   447 447 PHE PHE A . n 
A 1 9   HIS 9   448 448 HIS HIS A . n 
A 1 10  VAL 10  449 449 VAL VAL A . n 
A 1 11  GLN 11  450 450 GLN GLN A . n 
A 1 12  TYR 12  451 451 TYR TYR A . n 
A 1 13  SER 13  452 452 SER SER A . n 
A 1 14  VAL 14  453 453 VAL VAL A . n 
A 1 15  GLY 15  454 454 GLY GLY A . n 
A 1 16  GLU 16  455 455 GLU GLU A . n 
A 1 17  GLY 17  456 456 GLY GLY A . n 
A 1 18  LEU 18  457 457 LEU LEU A . n 
A 1 19  GLY 19  458 458 GLY GLY A . n 
A 1 20  PRO 20  459 459 PRO PRO A . n 
A 1 21  THR 21  460 460 THR THR A . n 
A 1 22  ALA 22  461 461 ALA ALA A . n 
A 1 23  ASP 23  462 462 ASP ASP A . n 
A 1 24  PHE 24  463 463 PHE PHE A . n 
A 1 25  PRO 25  464 464 PRO PRO A . n 
A 1 26  ASN 26  465 465 ASN ASN A . n 
A 1 27  GLY 27  466 466 GLY GLY A . n 
A 1 28  ARG 28  467 467 ARG ARG A . n 
A 1 29  TYR 29  468 468 TYR TYR A . n 
A 1 30  GLN 30  469 469 GLN GLN A . n 
A 1 31  ILE 31  470 470 ILE ILE A . n 
A 1 32  LEU 32  471 471 LEU LEU A . n 
A 1 33  ALA 33  472 472 ALA ALA A . n 
A 1 34  PRO 34  473 473 PRO PRO A . n 
A 1 35  LEU 35  474 474 LEU LEU A . n 
A 1 36  GLY 36  475 475 GLY GLY A . n 
A 1 37  SER 37  476 476 SER SER A . n 
A 1 38  GLY 38  477 477 GLY GLY A . n 
A 1 39  THR 39  478 478 THR THR A . n 
A 1 40  PHE 40  479 479 PHE PHE A . n 
A 1 41  GLY 41  480 480 GLY GLY A . n 
A 1 42  LYS 42  481 481 LYS LYS A . n 
A 1 43  VAL 43  482 482 VAL VAL A . n 
A 1 44  VAL 44  483 483 VAL VAL A . n 
A 1 45  SER 45  484 484 SER SER A . n 
A 1 46  CYS 46  485 485 CYS CYS A . n 
A 1 47  TRP 47  486 486 TRP TRP A . n 
A 1 48  ASP 48  487 487 ASP ASP A . n 
A 1 49  ARG 49  488 488 ARG ARG A . n 
A 1 50  VAL 50  489 489 VAL VAL A . n 
A 1 51  THR 51  490 490 THR THR A . n 
A 1 52  GLU 52  491 491 GLU GLU A . n 
A 1 53  GLN 53  492 492 GLN GLN A . n 
A 1 54  LEU 54  493 493 LEU LEU A . n 
A 1 55  VAL 55  494 494 VAL VAL A . n 
A 1 56  ALA 56  495 495 ALA ALA A . n 
A 1 57  VAL 57  496 496 VAL VAL A . n 
A 1 58  LYS 58  497 497 LYS LYS A . n 
A 1 59  VAL 59  498 498 VAL VAL A . n 
A 1 60  ILE 60  499 499 ILE ILE A . n 
A 1 61  ARG 61  500 500 ARG ARG A . n 
A 1 62  ALA 62  501 501 ALA ALA A . n 
A 1 63  VAL 63  502 502 VAL VAL A . n 
A 1 64  ARG 64  503 503 ARG ARG A . n 
A 1 65  LYS 65  504 504 LYS LYS A . n 
A 1 66  TYR 66  505 505 TYR TYR A . n 
A 1 67  ALA 67  506 506 ALA ALA A . n 
A 1 68  GLU 68  507 507 GLU GLU A . n 
A 1 69  ALA 69  508 508 ALA ALA A . n 
A 1 70  ALA 70  509 509 ALA ALA A . n 
A 1 71  ARG 71  510 510 ARG ARG A . n 
A 1 72  MET 72  511 511 MET MET A . n 
A 1 73  GLU 73  512 512 GLU GLU A . n 
A 1 74  ILE 74  513 513 ILE ILE A . n 
A 1 75  ASP 75  514 514 ASP ASP A . n 
A 1 76  ILE 76  515 515 ILE ILE A . n 
A 1 77  LEU 77  516 516 LEU LEU A . n 
A 1 78  LEU 78  517 517 LEU LEU A . n 
A 1 79  GLU 79  518 518 GLU GLU A . n 
A 1 80  LEU 80  519 519 LEU LEU A . n 
A 1 81  GLY 81  520 520 GLY GLY A . n 
A 1 82  ARG 82  521 521 ARG ARG A . n 
A 1 83  LYS 83  522 522 LYS LYS A . n 
A 1 84  ASP 84  523 523 ASP ASP A . n 
A 1 85  PRO 85  524 524 PRO PRO A . n 
A 1 86  THR 86  525 525 THR THR A . n 
A 1 87  SER 87  526 526 SER SER A . n 
A 1 88  ARG 88  527 527 ARG ARG A . n 
A 1 89  PHE 89  528 528 PHE PHE A . n 
A 1 90  HIS 90  529 529 HIS HIS A . n 
A 1 91  CYS 91  530 530 CYS CYS A . n 
A 1 92  VAL 92  531 531 VAL VAL A . n 
A 1 93  ARG 93  532 532 ARG ARG A . n 
A 1 94  MET 94  533 533 MET MET A . n 
A 1 95  LEU 95  534 534 LEU LEU A . n 
A 1 96  SER 96  535 535 SER SER A . n 
A 1 97  TYR 97  536 536 TYR TYR A . n 
A 1 98  PHE 98  537 537 PHE PHE A . n 
A 1 99  THR 99  538 538 THR THR A . n 
A 1 100 HIS 100 539 539 HIS HIS A . n 
A 1 101 VAL 101 540 540 VAL VAL A . n 
A 1 102 SER 102 541 541 SER SER A . n 
A 1 103 GLN 103 542 542 GLN GLN A . n 
A 1 104 GLN 104 543 543 GLN GLN A . n 
A 1 105 GLY 105 544 544 GLY GLY A . n 
A 1 106 ASN 106 545 545 ASN ASN A . n 
A 1 107 ALA 107 546 546 ALA ALA A . n 
A 1 108 HIS 108 547 547 HIS HIS A . n 
A 1 109 VAL 109 548 548 VAL VAL A . n 
A 1 110 CYS 110 549 549 CYS CYS A . n 
A 1 111 LEU 111 550 550 LEU LEU A . n 
A 1 112 VAL 112 551 551 VAL VAL A . n 
A 1 113 PHE 113 552 552 PHE PHE A . n 
A 1 114 GLU 114 553 553 GLU GLU A . n 
A 1 115 HIS 115 554 554 HIS HIS A . n 
A 1 116 LEU 116 555 555 LEU LEU A . n 
A 1 117 GLY 117 556 556 GLY GLY A . n 
A 1 118 PRO 118 557 557 PRO PRO A . n 
A 1 119 SER 119 558 558 SER SER A . n 
A 1 120 LEU 120 559 559 LEU LEU A . n 
A 1 121 PHE 121 560 560 PHE PHE A . n 
A 1 122 ASP 122 561 561 ASP ASP A . n 
A 1 123 VAL 123 562 562 VAL VAL A . n 
A 1 124 LEU 124 563 563 LEU LEU A . n 
A 1 125 MET 125 564 564 MET MET A . n 
A 1 126 ARG 126 565 565 ARG ARG A . n 
A 1 127 ASN 127 566 566 ASN ASN A . n 
A 1 128 HIS 128 567 567 HIS HIS A . n 
A 1 129 PHE 129 568 568 PHE PHE A . n 
A 1 130 ARG 130 569 569 ARG ARG A . n 
A 1 131 PRO 131 570 570 PRO PRO A . n 
A 1 132 LEU 132 571 571 LEU LEU A . n 
A 1 133 PRO 133 572 572 PRO PRO A . n 
A 1 134 VAL 134 573 573 VAL VAL A . n 
A 1 135 PRO 135 574 574 PRO PRO A . n 
A 1 136 ILE 136 575 575 ILE ILE A . n 
A 1 137 LEU 137 576 576 LEU LEU A . n 
A 1 138 ARG 138 577 577 ARG ARG A . n 
A 1 139 ALA 139 578 578 ALA ALA A . n 
A 1 140 VAL 140 579 579 VAL VAL A . n 
A 1 141 ALA 141 580 580 ALA ALA A . n 
A 1 142 ARG 142 581 581 ARG ARG A . n 
A 1 143 GLN 143 582 582 GLN GLN A . n 
A 1 144 LEU 144 583 583 LEU LEU A . n 
A 1 145 LEU 145 584 584 LEU LEU A . n 
A 1 146 GLU 146 585 585 GLU GLU A . n 
A 1 147 ALA 147 586 586 ALA ALA A . n 
A 1 148 ILE 148 587 587 ILE ILE A . n 
A 1 149 THR 149 588 588 THR THR A . n 
A 1 150 PHE 150 589 589 PHE PHE A . n 
A 1 151 LEU 151 590 590 LEU LEU A . n 
A 1 152 HIS 152 591 591 HIS HIS A . n 
A 1 153 GLU 153 592 592 GLU GLU A . n 
A 1 154 HIS 154 593 593 HIS HIS A . n 
A 1 155 ASN 155 594 594 ASN ASN A . n 
A 1 156 GLN 156 595 595 GLN GLN A . n 
A 1 157 ILE 157 596 596 ILE ILE A . n 
A 1 158 VAL 158 597 597 VAL VAL A . n 
A 1 159 HIS 159 598 598 HIS HIS A . n 
A 1 160 THR 160 599 599 THR THR A . n 
A 1 161 ASP 161 600 600 ASP ASP A . n 
A 1 162 ILE 162 601 601 ILE ILE A . n 
A 1 163 LYS 163 602 602 LYS LYS A . n 
A 1 164 PRO 164 603 603 PRO PRO A . n 
A 1 165 GLU 165 604 604 GLU GLU A . n 
A 1 166 ASN 166 605 605 ASN ASN A . n 
A 1 167 VAL 167 606 606 VAL VAL A . n 
A 1 168 LEU 168 607 607 LEU LEU A . n 
A 1 169 ILE 169 608 608 ILE ILE A . n 
A 1 170 VAL 170 609 609 VAL VAL A . n 
A 1 171 PRO 171 610 610 PRO PRO A . n 
A 1 172 SER 172 611 611 SER SER A . n 
A 1 173 SER 173 612 612 SER SER A . n 
A 1 174 TYR 174 613 613 TYR TYR A . n 
A 1 175 TYR 175 614 614 TYR TYR A . n 
A 1 176 PRO 176 615 615 PRO PRO A . n 
A 1 177 ASN 177 616 616 ASN ASN A . n 
A 1 178 ARG 178 617 617 ARG ARG A . n 
A 1 179 GLN 179 618 618 GLN GLN A . n 
A 1 180 ILE 180 619 619 ILE ILE A . n 
A 1 181 THR 181 620 620 THR THR A . n 
A 1 182 GLU 182 621 621 GLU GLU A . n 
A 1 183 HIS 183 622 622 HIS HIS A . n 
A 1 184 VAL 184 623 623 VAL VAL A . n 
A 1 185 GLN 185 624 624 GLN GLN A . n 
A 1 186 VAL 186 625 625 VAL VAL A . n 
A 1 187 ARG 187 626 626 ARG ARG A . n 
A 1 188 LEU 188 627 627 LEU LEU A . n 
A 1 189 ILE 189 628 628 ILE ILE A . n 
A 1 190 ASP 190 629 629 ASP ASP A . n 
A 1 191 PHE 191 630 630 PHE PHE A . n 
A 1 192 GLY 192 631 631 GLY GLY A . n 
A 1 193 SER 193 632 632 SER SER A . n 
A 1 194 ALA 194 633 633 ALA ALA A . n 
A 1 195 SER 195 634 634 SER SER A . n 
A 1 196 ARG 196 635 635 ARG ARG A . n 
A 1 197 LEU 197 636 636 LEU LEU A . n 
A 1 198 ASP 198 637 637 ASP ASP A . n 
A 1 199 LYS 199 638 638 LYS LYS A . n 
A 1 200 VAL 200 639 639 VAL VAL A . n 
A 1 201 SER 201 640 640 SER SER A . n 
A 1 202 VAL 202 641 641 VAL VAL A . n 
A 1 203 ARG 203 642 642 ARG ARG A . n 
A 1 204 HIS 204 643 643 HIS HIS A . n 
A 1 205 ALA 205 644 644 ALA ALA A . n 
A 1 206 ILE 206 645 645 ILE ILE A . n 
A 1 207 VAL 207 646 646 VAL VAL A . n 
A 1 208 SER 208 647 647 SER SER A . n 
A 1 209 THR 209 648 648 THR THR A . n 
A 1 210 ARG 210 649 649 ARG ARG A . n 
A 1 211 HIS 211 650 650 HIS HIS A . n 
A 1 212 TYR 212 651 651 TYR TYR A . n 
A 1 213 ARG 213 652 652 ARG ARG A . n 
A 1 214 ALA 214 653 653 ALA ALA A . n 
A 1 215 PRO 215 654 654 PRO PRO A . n 
A 1 216 GLU 216 655 655 GLU GLU A . n 
A 1 217 ILE 217 656 656 ILE ILE A . n 
A 1 218 ILE 218 657 657 ILE ILE A . n 
A 1 219 LEU 219 658 658 LEU LEU A . n 
A 1 220 GLY 220 659 659 GLY GLY A . n 
A 1 221 THR 221 660 660 THR THR A . n 
A 1 222 GLY 222 661 661 GLY GLY A . n 
A 1 223 TRP 223 662 662 TRP TRP A . n 
A 1 224 SER 224 663 663 SER SER A . n 
A 1 225 PHE 225 664 664 PHE PHE A . n 
A 1 226 ALA 226 665 665 ALA ALA A . n 
A 1 227 CYS 227 666 666 CYS CYS A . n 
A 1 228 ASP 228 667 667 ASP ASP A . n 
A 1 229 ILE 229 668 668 ILE ILE A . n 
A 1 230 TRP 230 669 669 TRP TRP A . n 
A 1 231 SER 231 670 670 SER SER A . n 
A 1 232 PHE 232 671 671 PHE PHE A . n 
A 1 233 GLY 233 672 672 GLY GLY A . n 
A 1 234 ALA 234 673 673 ALA ALA A . n 
A 1 235 LEU 235 674 674 LEU LEU A . n 
A 1 236 LEU 236 675 675 LEU LEU A . n 
A 1 237 VAL 237 676 676 VAL VAL A . n 
A 1 238 GLU 238 677 677 GLU GLU A . n 
A 1 239 CYS 239 678 678 CYS CYS A . n 
A 1 240 TYR 240 679 679 TYR TYR A . n 
A 1 241 THR 241 680 680 THR THR A . n 
A 1 242 GLY 242 681 681 GLY GLY A . n 
A 1 243 GLN 243 682 682 GLN GLN A . n 
A 1 244 THR 244 683 683 THR THR A . n 
A 1 245 LEU 245 684 684 LEU LEU A . n 
A 1 246 PHE 246 685 685 PHE PHE A . n 
A 1 247 GLN 247 686 686 GLN GLN A . n 
A 1 248 SER 248 687 687 SER SER A . n 
A 1 249 HIS 249 688 688 HIS HIS A . n 
A 1 250 ASP 250 689 689 ASP ASP A . n 
A 1 251 ASP 251 690 690 ASP ASP A . n 
A 1 252 LEU 252 691 691 LEU LEU A . n 
A 1 253 GLU 253 692 692 GLU GLU A . n 
A 1 254 HIS 254 693 693 HIS HIS A . n 
A 1 255 LEU 255 694 694 LEU LEU A . n 
A 1 256 GLN 256 695 695 GLN GLN A . n 
A 1 257 LEU 257 696 696 LEU LEU A . n 
A 1 258 MET 258 697 697 MET MET A . n 
A 1 259 GLN 259 698 698 GLN GLN A . n 
A 1 260 LYS 260 699 699 LYS LYS A . n 
A 1 261 LEU 261 700 700 LEU LEU A . n 
A 1 262 LEU 262 701 701 LEU LEU A . n 
A 1 263 GLN 263 702 702 GLN GLN A . n 
A 1 264 HIS 264 703 703 HIS HIS A . n 
A 1 265 GLU 265 704 704 GLU GLU A . n 
A 1 266 ASN 266 705 705 ASN ASN A . n 
A 1 267 GLY 267 706 706 GLY GLY A . n 
A 1 268 GLU 268 707 707 GLU GLU A . n 
A 1 269 VAL 269 708 708 VAL VAL A . n 
A 1 270 ILE 270 709 709 ILE ILE A . n 
A 1 271 VAL 271 710 710 VAL VAL A . n 
A 1 272 PRO 272 711 711 PRO PRO A . n 
A 1 273 PRO 273 712 712 PRO PRO A . n 
A 1 274 PRO 274 713 713 PRO PRO A . n 
A 1 275 ARG 275 714 714 ARG ARG A . n 
A 1 276 PRO 276 715 715 PRO PRO A . n 
A 1 277 SER 277 716 716 SER SER A . n 
A 1 278 PRO 278 717 717 PRO PRO A . n 
A 1 279 SER 279 718 718 SER SER A . n 
A 1 280 SER 280 719 719 SER SER A . n 
A 1 281 THR 281 720 720 THR THR A . n 
A 1 282 SER 282 721 721 SER SER A . n 
A 1 283 MET 283 722 722 MET MET A . n 
A 1 284 GLY 284 723 723 GLY GLY A . n 
A 1 285 SER 285 724 724 SER SER A . n 
A 1 286 GLN 286 725 725 GLN GLN A . n 
A 1 287 ARG 287 726 726 ARG ARG A . n 
A 1 288 ARG 288 727 727 ARG ARG A . n 
A 1 289 ARG 289 728 728 ARG ARG A . n 
A 1 290 GLU 290 729 729 GLU GLU A . n 
A 1 291 ALA 291 730 730 ALA ALA A . n 
A 1 292 LEU 292 731 731 LEU LEU A . n 
A 1 293 LYS 293 732 732 LYS LYS A . n 
A 1 294 LEU 294 733 733 LEU LEU A . n 
A 1 295 PHE 295 734 734 PHE PHE A . n 
A 1 296 ARG 296 735 735 ARG ARG A . n 
A 1 297 ASP 297 736 736 ASP ASP A . n 
A 1 298 GLY 298 737 737 GLY GLY A . n 
A 1 299 ARG 299 738 738 ARG ARG A . n 
A 1 300 LEU 300 739 739 LEU LEU A . n 
A 1 301 ASN 301 740 740 ASN ASN A . n 
A 1 302 TRP 302 741 741 TRP TRP A . n 
A 1 303 PRO 303 742 742 PRO PRO A . n 
A 1 304 GLU 304 743 743 GLU GLU A . n 
A 1 305 GLY 305 744 744 GLY GLY A . n 
A 1 306 ILE 306 745 745 ILE ILE A . n 
A 1 307 ASP 307 746 746 ASP ASP A . n 
A 1 308 GLU 308 747 ?   ?   ?   A . n 
A 1 309 GLN 309 748 ?   ?   ?   A . n 
A 1 310 SER 310 749 ?   ?   ?   A . n 
A 1 311 ALA 311 750 ?   ?   ?   A . n 
A 1 312 ASN 312 751 ?   ?   ?   A . n 
A 1 313 SER 313 752 ?   ?   ?   A . n 
A 1 314 LEU 314 753 753 LEU LEU A . n 
A 1 315 ALA 315 754 754 ALA ALA A . n 
A 1 316 ARG 316 755 755 ARG ARG A . n 
A 1 317 GLN 317 756 756 GLN GLN A . n 
A 1 318 LYS 318 757 757 LYS LYS A . n 
A 1 319 SER 319 758 758 SER SER A . n 
A 1 320 ILE 320 759 759 ILE ILE A . n 
A 1 321 ARG 321 760 760 ARG ARG A . n 
A 1 322 ARG 322 761 761 ARG ARG A . n 
A 1 323 VAL 323 762 762 VAL VAL A . n 
A 1 324 ALA 324 763 763 ALA ALA A . n 
A 1 325 ARG 325 764 764 ARG ARG A . n 
A 1 326 MET 326 765 765 MET MET A . n 
A 1 327 PRO 327 766 766 PRO PRO A . n 
A 1 328 GLU 328 767 767 GLU GLU A . n 
A 1 329 LEU 329 768 768 LEU LEU A . n 
A 1 330 HIS 330 769 769 HIS HIS A . n 
A 1 331 SER 331 770 770 SER SER A . n 
A 1 332 ILE 332 771 771 ILE ILE A . n 
A 1 333 PHE 333 772 772 PHE PHE A . n 
A 1 334 ARG 334 773 773 ARG ARG A . n 
A 1 335 PRO 335 774 774 PRO PRO A . n 
A 1 336 GLU 336 775 775 GLU GLU A . n 
A 1 337 HIS 337 776 776 HIS HIS A . n 
A 1 338 ALA 338 777 777 ALA ALA A . n 
A 1 339 CYS 339 778 778 CYS CYS A . n 
A 1 340 LEU 340 779 779 LEU LEU A . n 
A 1 341 LEU 341 780 780 LEU LEU A . n 
A 1 342 HIS 342 781 781 HIS HIS A . n 
A 1 343 LEU 343 782 782 LEU LEU A . n 
A 1 344 ILE 344 783 783 ILE ILE A . n 
A 1 345 ARG 345 784 784 ARG ARG A . n 
A 1 346 CYS 346 785 785 CYS CYS A . n 
A 1 347 CYS 347 786 786 CYS CYS A . n 
A 1 348 LEU 348 787 787 LEU LEU A . n 
A 1 349 THR 349 788 788 THR THR A . n 
A 1 350 ILE 350 789 789 ILE ILE A . n 
A 1 351 ASP 351 790 790 ASP ASP A . n 
A 1 352 PRO 352 791 791 PRO PRO A . n 
A 1 353 LEU 353 792 792 LEU LEU A . n 
A 1 354 LYS 354 793 793 LYS LYS A . n 
A 1 355 ARG 355 794 794 ARG ARG A . n 
A 1 356 TRP 356 795 795 TRP TRP A . n 
A 1 357 ARG 357 796 796 ARG ARG A . n 
A 1 358 PRO 358 797 797 PRO PRO A . n 
A 1 359 SER 359 798 798 SER SER A . n 
A 1 360 GLU 360 799 799 GLU GLU A . n 
A 1 361 LEU 361 800 800 LEU LEU A . n 
A 1 362 LEU 362 801 801 LEU LEU A . n 
A 1 363 ARG 363 802 802 ARG ARG A . n 
A 1 364 HIS 364 803 803 HIS HIS A . n 
A 1 365 PRO 365 804 804 PRO PRO A . n 
A 1 366 PHE 366 805 805 PHE PHE A . n 
A 1 367 PHE 367 806 806 PHE PHE A . n 
A 1 368 MET 368 807 807 MET MET A . n 
A 1 369 SER 369 808 ?   ?   ?   A . n 
A 1 370 TYR 370 809 ?   ?   ?   A . n 
A 1 371 SER 371 810 ?   ?   ?   A . n 
A 1 372 THR 372 811 ?   ?   ?   A . n 
A 1 373 GLU 373 812 ?   ?   ?   A . n 
A 1 374 ALA 374 813 ?   ?   ?   A . n 
A 1 375 THR 375 814 ?   ?   ?   A . n 
A 1 376 PRO 376 815 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1  901  401 EDO EDO A . 
C 3 ZN  1  902  1   ZN  ZN  A . 
D 4 HOH 1  1001 8   HOH HOH A . 
D 4 HOH 2  1002 7   HOH HOH A . 
D 4 HOH 3  1003 6   HOH HOH A . 
D 4 HOH 4  1004 2   HOH HOH A . 
D 4 HOH 5  1005 1   HOH HOH A . 
D 4 HOH 6  1006 5   HOH HOH A . 
D 4 HOH 7  1007 11  HOH HOH A . 
D 4 HOH 8  1008 4   HOH HOH A . 
D 4 HOH 9  1009 12  HOH HOH A . 
D 4 HOH 10 1010 10  HOH HOH A . 
D 4 HOH 11 1011 13  HOH HOH A . 
D 4 HOH 12 1012 3   HOH HOH A . 
D 4 HOH 13 1013 9   HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.15.2_3472: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FMO 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     65.522 
_cell.length_a_esd                 ? 
_cell.length_b                     70.393 
_cell.length_b_esd                 ? 
_cell.length_c                     88.228 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FMO 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FMO 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.49 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.52 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Tris pH 8.0, 20 % (v/v) ethanol, 30 % (w/v) ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 2M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-04-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    Si111 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'BESSY BEAMLINE 14.2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   14.2 
_diffrn_source.pdbx_synchrotron_site       BESSY 
# 
_reflns.B_iso_Wilson_estimate                          54.48 
_reflns.entry_id                                       9FMO 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.487 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     14748 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.39 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.49 
_reflns_shell.d_res_low                                     2.64 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.95 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2323 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.327 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FMO 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.487 
_refine.ls_d_res_low                             37.380 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     14723 
_refine.ls_number_reflns_R_free                  737 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.91 
_refine.ls_percent_reflns_R_free                 5.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2318 
_refine.ls_R_factor_R_free                       0.2668 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2299 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 30.33 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.40 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.487 
_refine_hist.d_res_low                        37.380 
_refine_hist.number_atoms_solvent             13 
_refine_hist.number_atoms_total               2898 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2880 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003 ? 2982 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.572 ? 4043 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 5.550 ? 2506 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.045 ? 443  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.004 ? 524  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.487  2.6789 . . 145 2750 99.00  . . . . 0.3211 . . . . . . . . . . . 0.3586 
'X-RAY DIFFRACTION' 2.6789 2.9483 . . 145 2752 99.00  . . . . 0.3056 . . . . . . . . . . . 0.4032 
'X-RAY DIFFRACTION' 2.9483 3.3747 . . 145 2751 99.00  . . . . 0.2748 . . . . . . . . . . . 0.3295 
'X-RAY DIFFRACTION' 3.3747 4.2509 . . 149 2831 100.00 . . . . 0.2097 . . . . . . . . . . . 0.2522 
'X-RAY DIFFRACTION' 4.2509 37.380 . . 153 2902 98.00  . . . . 0.1950 . . . . . . . . . . . 0.2106 
# 
_struct.entry_id                     9FMO 
_struct.title                        'Crystal structure of C. merolae LAMMER-like dual specificity kinase (CmLIK) kinase domain' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FMO 
_struct_keywords.text            'SERINE/THREONINE-PROTEIN KINASE, TYROSINE-PROTEIN KINASE, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    M1UWB5_CYAM1 
_struct_ref.pdbx_db_accession          M1UWB5 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;HVQYSVGEGLGPTADFPNGRYQILAPLGSGTFGKVVSCWDRVTEQLVAVKVIRAVRKYAEAARMEIDILLELGRKDPTSR
FHCVRMLSYFTHVSQQGNAHVCLVFEHLGPSLFDVLMRNHFRPLPVPILRAVARQLLEAITFLHEHNQIVHTDIKPENVL
IVPSSYYPNRQITEHVQVRLIDFGSASRLDKVSVRHAIVSTRHYRAPEIILGTGWSFACDIWSFGALLVECYTGQTLFQS
HDDLEHLQLMQKLLQHENGEVIVPPPRPSPSSTSMGSQRRREALKLFRDGRLNWPEGIDEQSANSLARQKSIRRVARMPE
LHSIFRPEHACLLHLIRCCLTIDPLKRWRPSELLRHPFFMSYSTEATP
;
_struct_ref.pdbx_align_begin           448 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FMO 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 9 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 376 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             M1UWB5 
_struct_ref_seq.db_align_beg                  448 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  815 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       448 
_struct_ref_seq.pdbx_auth_seq_align_end       815 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FMO GLY A 1 ? UNP M1UWB5 ? ? 'expression tag' 440 1 
1 9FMO PRO A 2 ? UNP M1UWB5 ? ? 'expression tag' 441 2 
1 9FMO LEU A 3 ? UNP M1UWB5 ? ? 'expression tag' 442 3 
1 9FMO GLY A 4 ? UNP M1UWB5 ? ? 'expression tag' 443 4 
1 9FMO SER A 5 ? UNP M1UWB5 ? ? 'expression tag' 444 5 
1 9FMO PRO A 6 ? UNP M1UWB5 ? ? 'expression tag' 445 6 
1 9FMO GLU A 7 ? UNP M1UWB5 ? ? 'expression tag' 446 7 
1 9FMO PHE A 8 ? UNP M1UWB5 ? ? 'expression tag' 447 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 300   ? 
1 MORE         -21   ? 
1 'SSA (A^2)'  17110 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 63  ? ASP A 84  ? VAL A 502 ASP A 523 1 ? 22 
HELX_P HELX_P2  AA2 SER A 119 ? ASN A 127 ? SER A 558 ASN A 566 1 ? 9  
HELX_P HELX_P3  AA3 PRO A 133 ? GLN A 156 ? PRO A 572 GLN A 595 1 ? 24 
HELX_P HELX_P4  AA4 LYS A 163 ? GLU A 165 ? LYS A 602 GLU A 604 5 ? 3  
HELX_P HELX_P5  AA5 THR A 209 ? ARG A 213 ? THR A 648 ARG A 652 5 ? 5  
HELX_P HELX_P6  AA6 ALA A 214 ? GLY A 220 ? ALA A 653 GLY A 659 1 ? 7  
HELX_P HELX_P7  AA7 PHE A 225 ? GLY A 242 ? PHE A 664 GLY A 681 1 ? 18 
HELX_P HELX_P8  AA8 ASP A 250 ? GLN A 263 ? ASP A 689 GLN A 702 1 ? 14 
HELX_P HELX_P9  AA9 SER A 282 ? LYS A 293 ? SER A 721 LYS A 732 1 ? 12 
HELX_P HELX_P10 AB1 PRO A 303 ? ASP A 307 ? PRO A 742 ASP A 746 5 ? 5  
HELX_P HELX_P11 AB2 ALA A 315 ? MET A 326 ? ALA A 754 MET A 765 1 ? 12 
HELX_P HELX_P12 AB3 GLU A 328 ? PHE A 333 ? GLU A 767 PHE A 772 1 ? 6  
HELX_P HELX_P13 AB4 ARG A 334 ? GLU A 336 ? ARG A 773 GLU A 775 5 ? 3  
HELX_P HELX_P14 AB5 HIS A 337 ? CYS A 346 ? HIS A 776 CYS A 785 1 ? 10 
HELX_P HELX_P15 AB6 ASP A 351 ? ARG A 355 ? ASP A 790 ARG A 794 5 ? 5  
HELX_P HELX_P16 AB7 ARG A 357 ? ARG A 363 ? ARG A 796 ARG A 802 1 ? 7  
HELX_P HELX_P17 AB8 HIS A 364 ? MET A 368 ? HIS A 803 MET A 807 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            339 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           C 
_struct_conn.ptnr2_label_comp_id           ZN 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           ZN 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             778 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            ZN 
_struct_conn.ptnr2_auth_seq_id             902 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.729 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          TRP 
_struct_mon_prot_cis.label_seq_id           302 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           TRP 
_struct_mon_prot_cis.auth_seq_id            741 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    303 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     742 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       3.72 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 17  ? LEU A 18  ? GLY A 456 LEU A 457 
AA1 2 TYR A 29  ? GLY A 38  ? TYR A 468 GLY A 477 
AA1 3 GLY A 41  ? ASP A 48  ? GLY A 480 ASP A 487 
AA1 4 GLN A 53  ? ILE A 60  ? GLN A 492 ILE A 499 
AA1 5 ALA A 107 ? GLU A 114 ? ALA A 546 GLU A 553 
AA1 6 MET A 94  ? VAL A 101 ? MET A 533 VAL A 540 
AA2 1 ILE A 157 ? VAL A 158 ? ILE A 596 VAL A 597 
AA2 2 SER A 195 ? ARG A 196 ? SER A 634 ARG A 635 
AA3 1 VAL A 167 ? ILE A 169 ? VAL A 606 ILE A 608 
AA3 2 VAL A 186 ? LEU A 188 ? VAL A 625 LEU A 627 
AA4 1 PHE A 295 ? ARG A 296 ? PHE A 734 ARG A 735 
AA4 2 ARG A 299 ? LEU A 300 ? ARG A 738 LEU A 739 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 18  ? N LEU A 457 O TYR A 29  ? O TYR A 468 
AA1 2 3 N LEU A 32  ? N LEU A 471 O SER A 45  ? O SER A 484 
AA1 3 4 N CYS A 46  ? N CYS A 485 O VAL A 55  ? O VAL A 494 
AA1 4 5 N ALA A 56  ? N ALA A 495 O PHE A 113 ? O PHE A 552 
AA1 5 6 O HIS A 108 ? O HIS A 547 N HIS A 100 ? N HIS A 539 
AA2 1 2 N VAL A 158 ? N VAL A 597 O SER A 195 ? O SER A 634 
AA3 1 2 N LEU A 168 ? N LEU A 607 O ARG A 187 ? O ARG A 626 
AA4 1 2 N ARG A 296 ? N ARG A 735 O ARG A 299 ? O ARG A 738 
# 
_pdbx_entry_details.entry_id                   9FMO 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 447 ? ? -122.64 -165.68 
2 1 ALA A 501 ? ? -69.81  68.62   
3 1 ASN A 594 ? ? -142.79 -8.29   
4 1 THR A 599 ? ? 75.40   -9.66   
5 1 ASP A 629 ? ? 61.43   80.50   
6 1 SER A 647 ? ? 68.70   144.33  
7 1 SER A 663 ? ? -147.68 -146.36 
8 1 GLU A 707 ? ? 54.72   72.72   
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ASN 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    705 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   GLY 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    706 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            -147.51 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 440 ? A GLY 1   
2  1 Y 1 A PRO 441 ? A PRO 2   
3  1 Y 1 A LEU 442 ? A LEU 3   
4  1 Y 1 A GLY 443 ? A GLY 4   
5  1 Y 1 A SER 444 ? A SER 5   
6  1 Y 1 A PRO 445 ? A PRO 6   
7  1 Y 1 A GLU 747 ? A GLU 308 
8  1 Y 1 A GLN 748 ? A GLN 309 
9  1 Y 1 A SER 749 ? A SER 310 
10 1 Y 1 A ALA 750 ? A ALA 311 
11 1 Y 1 A ASN 751 ? A ASN 312 
12 1 Y 1 A SER 752 ? A SER 313 
13 1 Y 1 A SER 808 ? A SER 369 
14 1 Y 1 A TYR 809 ? A TYR 370 
15 1 Y 1 A SER 810 ? A SER 371 
16 1 Y 1 A THR 811 ? A THR 372 
17 1 Y 1 A GLU 812 ? A GLU 373 
18 1 Y 1 A ALA 813 ? A ALA 374 
19 1 Y 1 A THR 814 ? A THR 375 
20 1 Y 1 A PRO 815 ? A PRO 376 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
EDO C1   C  N N 88  
EDO O1   O  N N 89  
EDO C2   C  N N 90  
EDO O2   O  N N 91  
EDO H11  H  N N 92  
EDO H12  H  N N 93  
EDO HO1  H  N N 94  
EDO H21  H  N N 95  
EDO H22  H  N N 96  
EDO HO2  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
LEU N    N  N N 193 
LEU CA   C  N S 194 
LEU C    C  N N 195 
LEU O    O  N N 196 
LEU CB   C  N N 197 
LEU CG   C  N N 198 
LEU CD1  C  N N 199 
LEU CD2  C  N N 200 
LEU OXT  O  N N 201 
LEU H    H  N N 202 
LEU H2   H  N N 203 
LEU HA   H  N N 204 
LEU HB2  H  N N 205 
LEU HB3  H  N N 206 
LEU HG   H  N N 207 
LEU HD11 H  N N 208 
LEU HD12 H  N N 209 
LEU HD13 H  N N 210 
LEU HD21 H  N N 211 
LEU HD22 H  N N 212 
LEU HD23 H  N N 213 
LEU HXT  H  N N 214 
LYS N    N  N N 215 
LYS CA   C  N S 216 
LYS C    C  N N 217 
LYS O    O  N N 218 
LYS CB   C  N N 219 
LYS CG   C  N N 220 
LYS CD   C  N N 221 
LYS CE   C  N N 222 
LYS NZ   N  N N 223 
LYS OXT  O  N N 224 
LYS H    H  N N 225 
LYS H2   H  N N 226 
LYS HA   H  N N 227 
LYS HB2  H  N N 228 
LYS HB3  H  N N 229 
LYS HG2  H  N N 230 
LYS HG3  H  N N 231 
LYS HD2  H  N N 232 
LYS HD3  H  N N 233 
LYS HE2  H  N N 234 
LYS HE3  H  N N 235 
LYS HZ1  H  N N 236 
LYS HZ2  H  N N 237 
LYS HZ3  H  N N 238 
LYS HXT  H  N N 239 
MET N    N  N N 240 
MET CA   C  N S 241 
MET C    C  N N 242 
MET O    O  N N 243 
MET CB   C  N N 244 
MET CG   C  N N 245 
MET SD   S  N N 246 
MET CE   C  N N 247 
MET OXT  O  N N 248 
MET H    H  N N 249 
MET H2   H  N N 250 
MET HA   H  N N 251 
MET HB2  H  N N 252 
MET HB3  H  N N 253 
MET HG2  H  N N 254 
MET HG3  H  N N 255 
MET HE1  H  N N 256 
MET HE2  H  N N 257 
MET HE3  H  N N 258 
MET HXT  H  N N 259 
PHE N    N  N N 260 
PHE CA   C  N S 261 
PHE C    C  N N 262 
PHE O    O  N N 263 
PHE CB   C  N N 264 
PHE CG   C  Y N 265 
PHE CD1  C  Y N 266 
PHE CD2  C  Y N 267 
PHE CE1  C  Y N 268 
PHE CE2  C  Y N 269 
PHE CZ   C  Y N 270 
PHE OXT  O  N N 271 
PHE H    H  N N 272 
PHE H2   H  N N 273 
PHE HA   H  N N 274 
PHE HB2  H  N N 275 
PHE HB3  H  N N 276 
PHE HD1  H  N N 277 
PHE HD2  H  N N 278 
PHE HE1  H  N N 279 
PHE HE2  H  N N 280 
PHE HZ   H  N N 281 
PHE HXT  H  N N 282 
PRO N    N  N N 283 
PRO CA   C  N S 284 
PRO C    C  N N 285 
PRO O    O  N N 286 
PRO CB   C  N N 287 
PRO CG   C  N N 288 
PRO CD   C  N N 289 
PRO OXT  O  N N 290 
PRO H    H  N N 291 
PRO HA   H  N N 292 
PRO HB2  H  N N 293 
PRO HB3  H  N N 294 
PRO HG2  H  N N 295 
PRO HG3  H  N N 296 
PRO HD2  H  N N 297 
PRO HD3  H  N N 298 
PRO HXT  H  N N 299 
SER N    N  N N 300 
SER CA   C  N S 301 
SER C    C  N N 302 
SER O    O  N N 303 
SER CB   C  N N 304 
SER OG   O  N N 305 
SER OXT  O  N N 306 
SER H    H  N N 307 
SER H2   H  N N 308 
SER HA   H  N N 309 
SER HB2  H  N N 310 
SER HB3  H  N N 311 
SER HG   H  N N 312 
SER HXT  H  N N 313 
THR N    N  N N 314 
THR CA   C  N S 315 
THR C    C  N N 316 
THR O    O  N N 317 
THR CB   C  N R 318 
THR OG1  O  N N 319 
THR CG2  C  N N 320 
THR OXT  O  N N 321 
THR H    H  N N 322 
THR H2   H  N N 323 
THR HA   H  N N 324 
THR HB   H  N N 325 
THR HG1  H  N N 326 
THR HG21 H  N N 327 
THR HG22 H  N N 328 
THR HG23 H  N N 329 
THR HXT  H  N N 330 
TRP N    N  N N 331 
TRP CA   C  N S 332 
TRP C    C  N N 333 
TRP O    O  N N 334 
TRP CB   C  N N 335 
TRP CG   C  Y N 336 
TRP CD1  C  Y N 337 
TRP CD2  C  Y N 338 
TRP NE1  N  Y N 339 
TRP CE2  C  Y N 340 
TRP CE3  C  Y N 341 
TRP CZ2  C  Y N 342 
TRP CZ3  C  Y N 343 
TRP CH2  C  Y N 344 
TRP OXT  O  N N 345 
TRP H    H  N N 346 
TRP H2   H  N N 347 
TRP HA   H  N N 348 
TRP HB2  H  N N 349 
TRP HB3  H  N N 350 
TRP HD1  H  N N 351 
TRP HE1  H  N N 352 
TRP HE3  H  N N 353 
TRP HZ2  H  N N 354 
TRP HZ3  H  N N 355 
TRP HH2  H  N N 356 
TRP HXT  H  N N 357 
TYR N    N  N N 358 
TYR CA   C  N S 359 
TYR C    C  N N 360 
TYR O    O  N N 361 
TYR CB   C  N N 362 
TYR CG   C  Y N 363 
TYR CD1  C  Y N 364 
TYR CD2  C  Y N 365 
TYR CE1  C  Y N 366 
TYR CE2  C  Y N 367 
TYR CZ   C  Y N 368 
TYR OH   O  N N 369 
TYR OXT  O  N N 370 
TYR H    H  N N 371 
TYR H2   H  N N 372 
TYR HA   H  N N 373 
TYR HB2  H  N N 374 
TYR HB3  H  N N 375 
TYR HD1  H  N N 376 
TYR HD2  H  N N 377 
TYR HE1  H  N N 378 
TYR HE2  H  N N 379 
TYR HH   H  N N 380 
TYR HXT  H  N N 381 
VAL N    N  N N 382 
VAL CA   C  N S 383 
VAL C    C  N N 384 
VAL O    O  N N 385 
VAL CB   C  N N 386 
VAL CG1  C  N N 387 
VAL CG2  C  N N 388 
VAL OXT  O  N N 389 
VAL H    H  N N 390 
VAL H2   H  N N 391 
VAL HA   H  N N 392 
VAL HB   H  N N 393 
VAL HG11 H  N N 394 
VAL HG12 H  N N 395 
VAL HG13 H  N N 396 
VAL HG21 H  N N 397 
VAL HG22 H  N N 398 
VAL HG23 H  N N 399 
VAL HXT  H  N N 400 
ZN  ZN   ZN N N 401 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
THR N   CA   sing N N 299 
THR N   H    sing N N 300 
THR N   H2   sing N N 301 
THR CA  C    sing N N 302 
THR CA  CB   sing N N 303 
THR CA  HA   sing N N 304 
THR C   O    doub N N 305 
THR C   OXT  sing N N 306 
THR CB  OG1  sing N N 307 
THR CB  CG2  sing N N 308 
THR CB  HB   sing N N 309 
THR OG1 HG1  sing N N 310 
THR CG2 HG21 sing N N 311 
THR CG2 HG22 sing N N 312 
THR CG2 HG23 sing N N 313 
THR OXT HXT  sing N N 314 
TRP N   CA   sing N N 315 
TRP N   H    sing N N 316 
TRP N   H2   sing N N 317 
TRP CA  C    sing N N 318 
TRP CA  CB   sing N N 319 
TRP CA  HA   sing N N 320 
TRP C   O    doub N N 321 
TRP C   OXT  sing N N 322 
TRP CB  CG   sing N N 323 
TRP CB  HB2  sing N N 324 
TRP CB  HB3  sing N N 325 
TRP CG  CD1  doub Y N 326 
TRP CG  CD2  sing Y N 327 
TRP CD1 NE1  sing Y N 328 
TRP CD1 HD1  sing N N 329 
TRP CD2 CE2  doub Y N 330 
TRP CD2 CE3  sing Y N 331 
TRP NE1 CE2  sing Y N 332 
TRP NE1 HE1  sing N N 333 
TRP CE2 CZ2  sing Y N 334 
TRP CE3 CZ3  doub Y N 335 
TRP CE3 HE3  sing N N 336 
TRP CZ2 CH2  doub Y N 337 
TRP CZ2 HZ2  sing N N 338 
TRP CZ3 CH2  sing Y N 339 
TRP CZ3 HZ3  sing N N 340 
TRP CH2 HH2  sing N N 341 
TRP OXT HXT  sing N N 342 
TYR N   CA   sing N N 343 
TYR N   H    sing N N 344 
TYR N   H2   sing N N 345 
TYR CA  C    sing N N 346 
TYR CA  CB   sing N N 347 
TYR CA  HA   sing N N 348 
TYR C   O    doub N N 349 
TYR C   OXT  sing N N 350 
TYR CB  CG   sing N N 351 
TYR CB  HB2  sing N N 352 
TYR CB  HB3  sing N N 353 
TYR CG  CD1  doub Y N 354 
TYR CG  CD2  sing Y N 355 
TYR CD1 CE1  sing Y N 356 
TYR CD1 HD1  sing N N 357 
TYR CD2 CE2  doub Y N 358 
TYR CD2 HD2  sing N N 359 
TYR CE1 CZ   doub Y N 360 
TYR CE1 HE1  sing N N 361 
TYR CE2 CZ   sing Y N 362 
TYR CE2 HE2  sing N N 363 
TYR CZ  OH   sing N N 364 
TYR OH  HH   sing N N 365 
TYR OXT HXT  sing N N 366 
VAL N   CA   sing N N 367 
VAL N   H    sing N N 368 
VAL N   H2   sing N N 369 
VAL CA  C    sing N N 370 
VAL CA  CB   sing N N 371 
VAL CA  HA   sing N N 372 
VAL C   O    doub N N 373 
VAL C   OXT  sing N N 374 
VAL CB  CG1  sing N N 375 
VAL CB  CG2  sing N N 376 
VAL CB  HB   sing N N 377 
VAL CG1 HG11 sing N N 378 
VAL CG1 HG12 sing N N 379 
VAL CG1 HG13 sing N N 380 
VAL CG2 HG21 sing N N 381 
VAL CG2 HG22 sing N N 382 
VAL CG2 HG23 sing N N 383 
VAL OXT HXT  sing N N 384 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2eu9 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FMO 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015262 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014206 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011334 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLU A 1 7   ? 14.973 -3.530  60.577 1.00 86.75  ? 446  GLU A N   1 
ATOM   2    C  CA  . GLU A 1 7   ? 14.784 -2.293  61.325 1.00 89.41  ? 446  GLU A CA  1 
ATOM   3    C  C   . GLU A 1 7   ? 15.177 -1.091  60.465 1.00 90.96  ? 446  GLU A C   1 
ATOM   4    O  O   . GLU A 1 7   ? 15.739 -1.257  59.382 1.00 90.82  ? 446  GLU A O   1 
ATOM   5    C  CB  . GLU A 1 7   ? 15.589 -2.329  62.626 1.00 88.01  ? 446  GLU A CB  1 
ATOM   6    C  CG  . GLU A 1 7   ? 15.215 -3.501  63.534 1.00 92.15  ? 446  GLU A CG  1 
ATOM   7    C  CD  . GLU A 1 7   ? 16.069 -3.590  64.792 1.00 91.19  ? 446  GLU A CD  1 
ATOM   8    O  OE1 . GLU A 1 7   ? 17.284 -3.307  64.723 1.00 88.47  ? 446  GLU A OE1 1 
ATOM   9    O  OE2 . GLU A 1 7   ? 15.521 -3.949  65.857 1.00 89.31  ? 446  GLU A OE2 1 
ATOM   10   N  N   . PHE A 1 8   ? 14.878 0.114   60.944 1.00 90.43  ? 447  PHE A N   1 
ATOM   11   C  CA  . PHE A 1 8   ? 15.035 1.336   60.163 1.00 87.14  ? 447  PHE A CA  1 
ATOM   12   C  C   . PHE A 1 8   ? 15.963 2.316   60.888 1.00 85.77  ? 447  PHE A C   1 
ATOM   13   O  O   . PHE A 1 8   ? 16.674 1.956   61.832 1.00 83.83  ? 447  PHE A O   1 
ATOM   14   C  CB  . PHE A 1 8   ? 13.666 1.960   59.880 1.00 89.66  ? 447  PHE A CB  1 
ATOM   15   C  CG  . PHE A 1 8   ? 12.600 0.955   59.548 1.00 92.52  ? 447  PHE A CG  1 
ATOM   16   C  CD1 . PHE A 1 8   ? 12.630 0.265   58.346 1.00 93.67  ? 447  PHE A CD1 1 
ATOM   17   C  CD2 . PHE A 1 8   ? 11.571 0.694   60.439 1.00 92.07  ? 447  PHE A CD2 1 
ATOM   18   C  CE1 . PHE A 1 8   ? 11.652 -0.665  58.037 1.00 93.12  ? 447  PHE A CE1 1 
ATOM   19   C  CE2 . PHE A 1 8   ? 10.590 -0.235  60.136 1.00 93.82  ? 447  PHE A CE2 1 
ATOM   20   C  CZ  . PHE A 1 8   ? 10.631 -0.915  58.934 1.00 92.74  ? 447  PHE A CZ  1 
ATOM   21   N  N   . HIS A 1 9   ? 15.950 3.569   60.430 1.00 83.78  ? 448  HIS A N   1 
ATOM   22   C  CA  . HIS A 1 9   ? 16.769 4.625   61.007 1.00 81.14  ? 448  HIS A CA  1 
ATOM   23   C  C   . HIS A 1 9   ? 16.132 5.154   62.291 1.00 79.06  ? 448  HIS A C   1 
ATOM   24   O  O   . HIS A 1 9   ? 15.029 4.761   62.679 1.00 77.99  ? 448  HIS A O   1 
ATOM   25   C  CB  . HIS A 1 9   ? 16.962 5.759   60.001 1.00 79.52  ? 448  HIS A CB  1 
ATOM   26   C  CG  . HIS A 1 9   ? 17.722 5.359   58.775 1.00 77.49  ? 448  HIS A CG  1 
ATOM   27   N  ND1 . HIS A 1 9   ? 19.099 5.333   58.731 1.00 75.92  ? 448  HIS A ND1 1 
ATOM   28   C  CD2 . HIS A 1 9   ? 17.298 4.974   57.547 1.00 77.29  ? 448  HIS A CD2 1 
ATOM   29   C  CE1 . HIS A 1 9   ? 19.492 4.945   57.531 1.00 76.82  ? 448  HIS A CE1 1 
ATOM   30   N  NE2 . HIS A 1 9   ? 18.419 4.721   56.793 1.00 78.60  ? 448  HIS A NE2 1 
ATOM   31   N  N   . VAL A 1 10  ? 16.834 6.071   62.956 1.00 77.26  ? 449  VAL A N   1 
ATOM   32   C  CA  . VAL A 1 10  ? 16.272 6.784   64.098 1.00 79.81  ? 449  VAL A CA  1 
ATOM   33   C  C   . VAL A 1 10  ? 15.347 7.886   63.601 1.00 78.66  ? 449  VAL A C   1 
ATOM   34   O  O   . VAL A 1 10  ? 15.522 8.438   62.506 1.00 78.27  ? 449  VAL A O   1 
ATOM   35   C  CB  . VAL A 1 10  ? 17.389 7.356   65.000 1.00 78.17  ? 449  VAL A CB  1 
ATOM   36   C  CG1 . VAL A 1 10  ? 18.018 8.601   64.370 1.00 73.84  ? 449  VAL A CG1 1 
ATOM   37   C  CG2 . VAL A 1 10  ? 16.853 7.656   66.384 1.00 75.01  ? 449  VAL A CG2 1 
ATOM   38   N  N   . GLN A 1 11  ? 14.337 8.206   64.406 1.00 77.72  ? 450  GLN A N   1 
ATOM   39   C  CA  . GLN A 1 11  ? 13.446 9.315   64.092 1.00 77.47  ? 450  GLN A CA  1 
ATOM   40   C  C   . GLN A 1 11  ? 13.427 10.290  65.254 1.00 75.64  ? 450  GLN A C   1 
ATOM   41   O  O   . GLN A 1 11  ? 13.157 9.899   66.397 1.00 77.03  ? 450  GLN A O   1 
ATOM   42   C  CB  . GLN A 1 11  ? 12.039 8.846   63.737 1.00 77.42  ? 450  GLN A CB  1 
ATOM   43   C  CG  . GLN A 1 11  ? 11.795 8.730   62.214 1.00 76.67  ? 450  GLN A CG  1 
ATOM   44   C  CD  . GLN A 1 11  ? 12.050 10.026  61.405 1.00 81.57  ? 450  GLN A CD  1 
ATOM   45   O  OE1 . GLN A 1 11  ? 12.738 10.951  61.848 1.00 78.44  ? 450  GLN A OE1 1 
ATOM   46   N  NE2 . GLN A 1 11  ? 11.471 10.085  60.207 1.00 81.50  ? 450  GLN A NE2 1 
ATOM   47   N  N   . TYR A 1 12  ? 13.697 11.558  64.943 1.00 73.39  ? 451  TYR A N   1 
ATOM   48   C  CA  . TYR A 1 12  ? 13.921 12.575  65.955 1.00 69.47  ? 451  TYR A CA  1 
ATOM   49   C  C   . TYR A 1 12  ? 13.268 13.879  65.526 1.00 70.00  ? 451  TYR A C   1 
ATOM   50   O  O   . TYR A 1 12  ? 13.111 14.157  64.333 1.00 68.78  ? 451  TYR A O   1 
ATOM   51   C  CB  . TYR A 1 12  ? 15.426 12.790  66.203 1.00 66.98  ? 451  TYR A CB  1 
ATOM   52   C  CG  . TYR A 1 12  ? 16.144 13.474  65.052 1.00 67.32  ? 451  TYR A CG  1 
ATOM   53   C  CD1 . TYR A 1 12  ? 16.272 14.859  65.003 1.00 65.88  ? 451  TYR A CD1 1 
ATOM   54   C  CD2 . TYR A 1 12  ? 16.700 12.731  64.020 1.00 66.58  ? 451  TYR A CD2 1 
ATOM   55   C  CE1 . TYR A 1 12  ? 16.924 15.484  63.950 1.00 66.20  ? 451  TYR A CE1 1 
ATOM   56   C  CE2 . TYR A 1 12  ? 17.356 13.342  62.967 1.00 67.12  ? 451  TYR A CE2 1 
ATOM   57   C  CZ  . TYR A 1 12  ? 17.464 14.720  62.935 1.00 66.19  ? 451  TYR A CZ  1 
ATOM   58   O  OH  . TYR A 1 12  ? 18.114 15.344  61.893 1.00 64.99  ? 451  TYR A OH  1 
ATOM   59   N  N   . SER A 1 13  ? 12.904 14.678  66.518 1.00 69.39  ? 452  SER A N   1 
ATOM   60   C  CA  . SER A 1 13  ? 12.545 16.070  66.311 1.00 66.95  ? 452  SER A CA  1 
ATOM   61   C  C   . SER A 1 13  ? 13.521 16.935  67.095 1.00 65.98  ? 452  SER A C   1 
ATOM   62   O  O   . SER A 1 13  ? 14.002 16.539  68.161 1.00 64.25  ? 452  SER A O   1 
ATOM   63   C  CB  . SER A 1 13  ? 11.108 16.364  66.750 1.00 65.94  ? 452  SER A CB  1 
ATOM   64   O  OG  . SER A 1 13  ? 10.268 15.259  66.481 1.00 71.52  ? 452  SER A OG  1 
ATOM   65   N  N   . VAL A 1 14  ? 13.835 18.109  66.542 1.00 64.44  ? 453  VAL A N   1 
ATOM   66   C  CA  . VAL A 1 14  ? 14.735 19.028  67.227 1.00 62.27  ? 453  VAL A CA  1 
ATOM   67   C  C   . VAL A 1 14  ? 14.162 19.366  68.594 1.00 61.33  ? 453  VAL A C   1 
ATOM   68   O  O   . VAL A 1 14  ? 12.984 19.721  68.724 1.00 65.11  ? 453  VAL A O   1 
ATOM   69   C  CB  . VAL A 1 14  ? 14.957 20.291  66.382 1.00 62.91  ? 453  VAL A CB  1 
ATOM   70   C  CG1 . VAL A 1 14  ? 15.589 21.385  67.226 1.00 59.18  ? 453  VAL A CG1 1 
ATOM   71   C  CG2 . VAL A 1 14  ? 15.816 19.973  65.163 1.00 61.72  ? 453  VAL A CG2 1 
ATOM   72   N  N   . GLY A 1 15  ? 14.993 19.238  69.631 1.00 58.13  ? 454  GLY A N   1 
ATOM   73   C  CA  . GLY A 1 15  ? 14.597 19.487  71.000 1.00 58.51  ? 454  GLY A CA  1 
ATOM   74   C  C   . GLY A 1 15  ? 14.558 18.238  71.858 1.00 62.22  ? 454  GLY A C   1 
ATOM   75   O  O   . GLY A 1 15  ? 14.766 18.326  73.076 1.00 62.18  ? 454  GLY A O   1 
ATOM   76   N  N   . GLU A 1 16  ? 14.297 17.082  71.256 1.00 62.36  ? 455  GLU A N   1 
ATOM   77   C  CA  . GLU A 1 16  ? 14.293 15.844  72.015 1.00 63.90  ? 455  GLU A CA  1 
ATOM   78   C  C   . GLU A 1 16  ? 15.725 15.432  72.349 1.00 61.89  ? 455  GLU A C   1 
ATOM   79   O  O   . GLU A 1 16  ? 16.692 15.883  71.729 1.00 60.36  ? 455  GLU A O   1 
ATOM   80   C  CB  . GLU A 1 16  ? 13.573 14.737  71.244 1.00 65.15  ? 455  GLU A CB  1 
ATOM   81   C  CG  . GLU A 1 16  ? 12.209 15.148  70.695 1.00 68.00  ? 455  GLU A CG  1 
ATOM   82   C  CD  . GLU A 1 16  ? 11.533 14.041  69.902 1.00 70.13  ? 455  GLU A CD  1 
ATOM   83   O  OE1 . GLU A 1 16  ? 11.768 13.954  68.679 1.00 68.67  ? 455  GLU A OE1 1 
ATOM   84   O  OE2 . GLU A 1 16  ? 10.763 13.262  70.502 1.00 71.05  ? 455  GLU A OE2 1 
ATOM   85   N  N   . GLY A 1 17  ? 15.854 14.571  73.354 1.00 60.81  ? 456  GLY A N   1 
ATOM   86   C  CA  . GLY A 1 17  ? 17.144 14.208  73.910 1.00 62.61  ? 456  GLY A CA  1 
ATOM   87   C  C   . GLY A 1 17  ? 17.558 12.798  73.535 1.00 61.60  ? 456  GLY A C   1 
ATOM   88   O  O   . GLY A 1 17  ? 16.714 11.934  73.285 1.00 62.27  ? 456  GLY A O   1 
ATOM   89   N  N   . LEU A 1 18  ? 18.869 12.573  73.506 1.00 59.66  ? 457  LEU A N   1 
ATOM   90   C  CA  . LEU A 1 18  ? 19.459 11.285  73.183 1.00 58.35  ? 457  LEU A CA  1 
ATOM   91   C  C   . LEU A 1 18  ? 20.186 10.721  74.397 1.00 60.68  ? 457  LEU A C   1 
ATOM   92   O  O   . LEU A 1 18  ? 20.763 11.463  75.197 1.00 60.44  ? 457  LEU A O   1 
ATOM   93   C  CB  . LEU A 1 18  ? 20.438 11.405  72.014 1.00 58.52  ? 457  LEU A CB  1 
ATOM   94   C  CG  . LEU A 1 18  ? 19.852 11.566  70.613 1.00 58.87  ? 457  LEU A CG  1 
ATOM   95   C  CD1 . LEU A 1 18  ? 20.948 11.953  69.634 1.00 55.73  ? 457  LEU A CD1 1 
ATOM   96   C  CD2 . LEU A 1 18  ? 19.160 10.287  70.174 1.00 58.17  ? 457  LEU A CD2 1 
ATOM   97   N  N   . GLY A 1 19  ? 20.158 9.396   74.519 1.00 62.50  ? 458  GLY A N   1 
ATOM   98   C  CA  . GLY A 1 19  ? 20.855 8.700   75.575 1.00 63.03  ? 458  GLY A CA  1 
ATOM   99   C  C   . GLY A 1 19  ? 20.455 9.148   76.966 1.00 65.36  ? 458  GLY A C   1 
ATOM   100  O  O   . GLY A 1 19  ? 21.215 9.828   77.665 1.00 67.12  ? 458  GLY A O   1 
ATOM   101  N  N   . PRO A 1 20  ? 19.253 8.767   77.399 1.00 64.88  ? 459  PRO A N   1 
ATOM   102  C  CA  . PRO A 1 20  ? 18.779 9.205   78.718 1.00 65.32  ? 459  PRO A CA  1 
ATOM   103  C  C   . PRO A 1 20  ? 19.622 8.627   79.844 1.00 63.78  ? 459  PRO A C   1 
ATOM   104  O  O   . PRO A 1 20  ? 20.026 7.462   79.812 1.00 62.03  ? 459  PRO A O   1 
ATOM   105  C  CB  . PRO A 1 20  ? 17.339 8.679   78.772 1.00 65.32  ? 459  PRO A CB  1 
ATOM   106  C  CG  . PRO A 1 20  ? 17.295 7.575   77.773 1.00 64.63  ? 459  PRO A CG  1 
ATOM   107  C  CD  . PRO A 1 20  ? 18.244 7.967   76.685 1.00 63.09  ? 459  PRO A CD  1 
ATOM   108  N  N   . THR A 1 21  ? 19.895 9.464   80.840 1.00 64.70  ? 460  THR A N   1 
ATOM   109  C  CA  . THR A 1 21  ? 20.597 9.065   82.052 1.00 65.74  ? 460  THR A CA  1 
ATOM   110  C  C   . THR A 1 21  ? 19.760 9.430   83.278 1.00 66.88  ? 460  THR A C   1 
ATOM   111  O  O   . THR A 1 21  ? 18.651 9.964   83.171 1.00 64.42  ? 460  THR A O   1 
ATOM   112  C  CB  . THR A 1 21  ? 21.987 9.709   82.128 1.00 63.60  ? 460  THR A CB  1 
ATOM   113  O  OG1 . THR A 1 21  ? 21.882 11.047  82.643 1.00 66.87  ? 460  THR A OG1 1 
ATOM   114  C  CG2 . THR A 1 21  ? 22.641 9.743   80.754 1.00 62.52  ? 460  THR A CG2 1 
ATOM   115  N  N   . ALA A 1 22  ? 20.326 9.149   84.457 1.00 68.25  ? 461  ALA A N   1 
ATOM   116  C  CA  . ALA A 1 22  ? 19.605 9.347   85.712 1.00 67.61  ? 461  ALA A CA  1 
ATOM   117  C  C   . ALA A 1 22  ? 19.230 10.810  85.922 1.00 68.27  ? 461  ALA A C   1 
ATOM   118  O  O   . ALA A 1 22  ? 18.104 11.119  86.330 1.00 68.75  ? 461  ALA A O   1 
ATOM   119  C  CB  . ALA A 1 22  ? 20.448 8.836   86.881 1.00 66.77  ? 461  ALA A CB  1 
ATOM   120  N  N   . ASP A 1 23  ? 20.159 11.725  85.649 1.00 68.08  ? 462  ASP A N   1 
ATOM   121  C  CA  . ASP A 1 23  ? 19.864 13.143  85.813 1.00 67.19  ? 462  ASP A CA  1 
ATOM   122  C  C   . ASP A 1 23  ? 19.002 13.688  84.682 1.00 67.10  ? 462  ASP A C   1 
ATOM   123  O  O   . ASP A 1 23  ? 18.184 14.585  84.913 1.00 67.24  ? 462  ASP A O   1 
ATOM   124  C  CB  . ASP A 1 23  ? 21.163 13.941  85.907 1.00 67.16  ? 462  ASP A CB  1 
ATOM   125  C  CG  . ASP A 1 23  ? 22.026 13.503  87.067 1.00 74.16  ? 462  ASP A CG  1 
ATOM   126  O  OD1 . ASP A 1 23  ? 22.464 12.333  87.076 1.00 76.78  ? 462  ASP A OD1 1 
ATOM   127  O  OD2 . ASP A 1 23  ? 22.261 14.329  87.973 1.00 78.51  ? 462  ASP A OD2 1 
ATOM   128  N  N   . PHE A 1 24  ? 19.164 13.169  83.462 1.00 66.39  ? 463  PHE A N   1 
ATOM   129  C  CA  . PHE A 1 24  ? 18.414 13.625  82.294 1.00 64.88  ? 463  PHE A CA  1 
ATOM   130  C  C   . PHE A 1 24  ? 17.677 12.431  81.702 1.00 65.81  ? 463  PHE A C   1 
ATOM   131  O  O   . PHE A 1 24  ? 18.120 11.850  80.700 1.00 67.02  ? 463  PHE A O   1 
ATOM   132  C  CB  . PHE A 1 24  ? 19.336 14.278  81.266 1.00 63.66  ? 463  PHE A CB  1 
ATOM   133  C  CG  . PHE A 1 24  ? 20.235 15.333  81.848 1.00 61.57  ? 463  PHE A CG  1 
ATOM   134  C  CD1 . PHE A 1 24  ? 19.778 16.629  82.026 1.00 60.09  ? 463  PHE A CD1 1 
ATOM   135  C  CD2 . PHE A 1 24  ? 21.532 15.026  82.232 1.00 60.72  ? 463  PHE A CD2 1 
ATOM   136  C  CE1 . PHE A 1 24  ? 20.601 17.604  82.568 1.00 58.56  ? 463  PHE A CE1 1 
ATOM   137  C  CE2 . PHE A 1 24  ? 22.360 15.993  82.777 1.00 58.63  ? 463  PHE A CE2 1 
ATOM   138  C  CZ  . PHE A 1 24  ? 21.893 17.285  82.945 1.00 57.54  ? 463  PHE A CZ  1 
ATOM   139  N  N   . PRO A 1 25  ? 16.548 12.031  82.295 1.00 68.24  ? 464  PRO A N   1 
ATOM   140  C  CA  . PRO A 1 25  ? 15.779 10.910  81.733 1.00 67.40  ? 464  PRO A CA  1 
ATOM   141  C  C   . PRO A 1 25  ? 15.194 11.203  80.364 1.00 68.40  ? 464  PRO A C   1 
ATOM   142  O  O   . PRO A 1 25  ? 14.746 10.267  79.688 1.00 68.95  ? 464  PRO A O   1 
ATOM   143  C  CB  . PRO A 1 25  ? 14.672 10.686  82.772 1.00 68.27  ? 464  PRO A CB  1 
ATOM   144  C  CG  . PRO A 1 25  ? 14.524 12.005  83.450 1.00 69.85  ? 464  PRO A CG  1 
ATOM   145  C  CD  . PRO A 1 25  ? 15.908 12.593  83.498 1.00 69.09  ? 464  PRO A CD  1 
ATOM   146  N  N   . ASN A 1 26  ? 15.174 12.463  79.937 1.00 67.43  ? 465  ASN A N   1 
ATOM   147  C  CA  . ASN A 1 26  ? 14.762 12.798  78.583 1.00 66.68  ? 465  ASN A CA  1 
ATOM   148  C  C   . ASN A 1 26  ? 15.917 12.765  77.592 1.00 64.23  ? 465  ASN A C   1 
ATOM   149  O  O   . ASN A 1 26  ? 15.677 12.862  76.382 1.00 61.67  ? 465  ASN A O   1 
ATOM   150  C  CB  . ASN A 1 26  ? 14.101 14.180  78.562 1.00 69.78  ? 465  ASN A CB  1 
ATOM   151  C  CG  . ASN A 1 26  ? 12.626 14.122  78.901 1.00 70.96  ? 465  ASN A CG  1 
ATOM   152  O  OD1 . ASN A 1 26  ? 12.152 13.152  79.495 1.00 71.25  ? 465  ASN A OD1 1 
ATOM   153  N  ND2 . ASN A 1 26  ? 11.890 15.163  78.525 1.00 66.54  ? 465  ASN A ND2 1 
ATOM   154  N  N   . GLY A 1 27  ? 17.153 12.627  78.073 1.00 63.35  ? 466  GLY A N   1 
ATOM   155  C  CA  . GLY A 1 27  ? 18.320 12.568  77.212 1.00 62.11  ? 466  GLY A CA  1 
ATOM   156  C  C   . GLY A 1 27  ? 19.422 13.533  77.604 1.00 60.77  ? 466  GLY A C   1 
ATOM   157  O  O   . GLY A 1 27  ? 19.175 14.730  77.776 1.00 61.64  ? 466  GLY A O   1 
ATOM   158  N  N   . ARG A 1 28  ? 20.649 13.024  77.743 1.00 59.93  ? 467  ARG A N   1 
ATOM   159  C  CA  . ARG A 1 28  ? 21.783 13.890  78.057 1.00 57.19  ? 467  ARG A CA  1 
ATOM   160  C  C   . ARG A 1 28  ? 22.138 14.809  76.892 1.00 56.26  ? 467  ARG A C   1 
ATOM   161  O  O   . ARG A 1 28  ? 22.588 15.939  77.110 1.00 54.51  ? 467  ARG A O   1 
ATOM   162  C  CB  . ARG A 1 28  ? 22.992 13.039  78.454 1.00 56.99  ? 467  ARG A CB  1 
ATOM   163  C  CG  . ARG A 1 28  ? 24.341 13.647  78.107 1.00 53.76  ? 467  ARG A CG  1 
ATOM   164  C  CD  . ARG A 1 28  ? 25.495 12.760  78.540 1.00 50.92  ? 467  ARG A CD  1 
ATOM   165  N  NE  . ARG A 1 28  ? 26.715 13.539  78.722 1.00 51.44  ? 467  ARG A NE  1 
ATOM   166  C  CZ  . ARG A 1 28  ? 27.884 13.031  79.097 1.00 54.39  ? 467  ARG A CZ  1 
ATOM   167  N  NH1 . ARG A 1 28  ? 28.004 11.729  79.333 1.00 52.39  ? 467  ARG A NH1 1 
ATOM   168  N  NH2 . ARG A 1 28  ? 28.936 13.826  79.240 1.00 53.21  ? 467  ARG A NH2 1 
ATOM   169  N  N   . TYR A 1 29  ? 21.938 14.353  75.657 1.00 56.65  ? 468  TYR A N   1 
ATOM   170  C  CA  . TYR A 1 29  ? 22.320 15.100  74.462 1.00 54.69  ? 468  TYR A CA  1 
ATOM   171  C  C   . TYR A 1 29  ? 21.054 15.643  73.806 1.00 55.89  ? 468  TYR A C   1 
ATOM   172  O  O   . TYR A 1 29  ? 20.314 14.902  73.153 1.00 58.01  ? 468  TYR A O   1 
ATOM   173  C  CB  . TYR A 1 29  ? 23.122 14.219  73.506 1.00 53.72  ? 468  TYR A CB  1 
ATOM   174  C  CG  . TYR A 1 29  ? 24.411 13.714  74.114 1.00 52.71  ? 468  TYR A CG  1 
ATOM   175  C  CD1 . TYR A 1 29  ? 25.475 14.578  74.348 1.00 51.64  ? 468  TYR A CD1 1 
ATOM   176  C  CD2 . TYR A 1 29  ? 24.559 12.381  74.472 1.00 52.09  ? 468  TYR A CD2 1 
ATOM   177  C  CE1 . TYR A 1 29  ? 26.653 14.127  74.913 1.00 51.73  ? 468  TYR A CE1 1 
ATOM   178  C  CE2 . TYR A 1 29  ? 25.734 11.919  75.038 1.00 51.92  ? 468  TYR A CE2 1 
ATOM   179  C  CZ  . TYR A 1 29  ? 26.776 12.796  75.258 1.00 52.79  ? 468  TYR A CZ  1 
ATOM   180  O  OH  . TYR A 1 29  ? 27.949 12.343  75.820 1.00 54.41  ? 468  TYR A OH  1 
ATOM   181  N  N   . GLN A 1 30  ? 20.813 16.940  73.982 1.00 55.71  ? 469  GLN A N   1 
ATOM   182  C  CA  . GLN A 1 30  ? 19.650 17.596  73.398 1.00 57.26  ? 469  GLN A CA  1 
ATOM   183  C  C   . GLN A 1 30  ? 19.917 17.898  71.929 1.00 53.12  ? 469  GLN A C   1 
ATOM   184  O  O   . GLN A 1 30  ? 20.880 18.596  71.598 1.00 52.33  ? 469  GLN A O   1 
ATOM   185  C  CB  . GLN A 1 30  ? 19.320 18.879  74.161 1.00 56.29  ? 469  GLN A CB  1 
ATOM   186  C  CG  . GLN A 1 30  ? 18.116 19.623  73.615 1.00 55.70  ? 469  GLN A CG  1 
ATOM   187  C  CD  . GLN A 1 30  ? 18.010 21.032  74.154 1.00 55.43  ? 469  GLN A CD  1 
ATOM   188  O  OE1 . GLN A 1 30  ? 18.015 21.247  75.365 1.00 57.91  ? 469  GLN A OE1 1 
ATOM   189  N  NE2 . GLN A 1 30  ? 17.911 22.005  73.254 1.00 54.61  ? 469  GLN A NE2 1 
ATOM   190  N  N   . ILE A 1 31  ? 19.057 17.382  71.054 1.00 55.69  ? 470  ILE A N   1 
ATOM   191  C  CA  . ILE A 1 31  ? 19.230 17.559  69.617 1.00 54.17  ? 470  ILE A CA  1 
ATOM   192  C  C   . ILE A 1 31  ? 18.973 19.017  69.260 1.00 54.91  ? 470  ILE A C   1 
ATOM   193  O  O   . ILE A 1 31  ? 17.908 19.569  69.563 1.00 56.93  ? 470  ILE A O   1 
ATOM   194  C  CB  . ILE A 1 31  ? 18.301 16.621  68.837 1.00 55.73  ? 470  ILE A CB  1 
ATOM   195  C  CG1 . ILE A 1 31  ? 18.629 15.161  69.170 1.00 57.65  ? 470  ILE A CG1 1 
ATOM   196  C  CG2 . ILE A 1 31  ? 18.416 16.882  67.340 1.00 56.93  ? 470  ILE A CG2 1 
ATOM   197  C  CD1 . ILE A 1 31  ? 17.536 14.177  68.809 1.00 57.18  ? 470  ILE A CD1 1 
ATOM   198  N  N   . LEU A 1 32  ? 19.951 19.648  68.613 1.00 53.33  ? 471  LEU A N   1 
ATOM   199  C  CA  . LEU A 1 32  ? 19.864 21.049  68.218 1.00 53.40  ? 471  LEU A CA  1 
ATOM   200  C  C   . LEU A 1 32  ? 19.536 21.225  66.741 1.00 53.95  ? 471  LEU A C   1 
ATOM   201  O  O   . LEU A 1 32  ? 18.603 21.955  66.397 1.00 53.62  ? 471  LEU A O   1 
ATOM   202  C  CB  . LEU A 1 32  ? 21.178 21.770  68.547 1.00 51.39  ? 471  LEU A CB  1 
ATOM   203  C  CG  . LEU A 1 32  ? 21.577 21.782  70.024 1.00 52.90  ? 471  LEU A CG  1 
ATOM   204  C  CD1 . LEU A 1 32  ? 22.931 22.437  70.217 1.00 49.07  ? 471  LEU A CD1 1 
ATOM   205  C  CD2 . LEU A 1 32  ? 20.517 22.484  70.855 1.00 51.63  ? 471  LEU A CD2 1 
ATOM   206  N  N   . ALA A 1 33  ? 20.285 20.573  65.857 1.00 55.16  ? 472  ALA A N   1 
ATOM   207  C  CA  . ALA A 1 33  ? 20.116 20.761  64.424 1.00 57.51  ? 472  ALA A CA  1 
ATOM   208  C  C   . ALA A 1 33  ? 20.654 19.533  63.706 1.00 58.92  ? 472  ALA A C   1 
ATOM   209  O  O   . ALA A 1 33  ? 21.511 18.821  64.244 1.00 57.70  ? 472  ALA A O   1 
ATOM   210  C  CB  . ALA A 1 33  ? 20.837 22.029  63.942 1.00 55.79  ? 472  ALA A CB  1 
ATOM   211  N  N   . PRO A 1 34  ? 20.170 19.254  62.496 1.00 62.94  ? 473  PRO A N   1 
ATOM   212  C  CA  . PRO A 1 34  ? 20.762 18.178  61.699 1.00 59.32  ? 473  PRO A CA  1 
ATOM   213  C  C   . PRO A 1 34  ? 22.119 18.584  61.155 1.00 58.71  ? 473  PRO A C   1 
ATOM   214  O  O   . PRO A 1 34  ? 22.357 19.744  60.814 1.00 59.87  ? 473  PRO A O   1 
ATOM   215  C  CB  . PRO A 1 34  ? 19.751 17.985  60.566 1.00 60.38  ? 473  PRO A CB  1 
ATOM   216  C  CG  . PRO A 1 34  ? 19.144 19.338  60.407 1.00 60.51  ? 473  PRO A CG  1 
ATOM   217  C  CD  . PRO A 1 34  ? 19.026 19.876  61.806 1.00 64.12  ? 473  PRO A CD  1 
ATOM   218  N  N   . LEU A 1 35  ? 23.020 17.604  61.082 1.00 58.86  ? 474  LEU A N   1 
ATOM   219  C  CA  . LEU A 1 35  ? 24.359 17.818  60.556 1.00 58.96  ? 474  LEU A CA  1 
ATOM   220  C  C   . LEU A 1 35  ? 24.641 17.046  59.277 1.00 61.37  ? 474  LEU A C   1 
ATOM   221  O  O   . LEU A 1 35  ? 25.558 17.425  58.538 1.00 65.82  ? 474  LEU A O   1 
ATOM   222  C  CB  . LEU A 1 35  ? 25.416 17.439  61.607 1.00 57.91  ? 474  LEU A CB  1 
ATOM   223  C  CG  . LEU A 1 35  ? 25.866 18.552  62.558 1.00 55.03  ? 474  LEU A CG  1 
ATOM   224  C  CD1 . LEU A 1 35  ? 26.947 18.059  63.509 1.00 50.23  ? 474  LEU A CD1 1 
ATOM   225  C  CD2 . LEU A 1 35  ? 26.354 19.746  61.765 1.00 53.99  ? 474  LEU A CD2 1 
ATOM   226  N  N   . GLY A 1 36  ? 23.879 16.009  58.986 1.00 59.16  ? 475  GLY A N   1 
ATOM   227  C  CA  . GLY A 1 36  ? 24.143 15.142  57.856 1.00 59.03  ? 475  GLY A CA  1 
ATOM   228  C  C   . GLY A 1 36  ? 23.621 13.753  58.143 1.00 61.98  ? 475  GLY A C   1 
ATOM   229  O  O   . GLY A 1 36  ? 23.290 13.406  59.275 1.00 63.04  ? 475  GLY A O   1 
ATOM   230  N  N   . SER A 1 37  ? 23.539 12.953  57.089 1.00 62.39  ? 476  SER A N   1 
ATOM   231  C  CA  . SER A 1 37  ? 22.981 11.613  57.225 1.00 63.87  ? 476  SER A CA  1 
ATOM   232  C  C   . SER A 1 37  ? 23.305 10.814  55.970 1.00 67.53  ? 476  SER A C   1 
ATOM   233  O  O   . SER A 1 37  ? 23.935 11.309  55.030 1.00 67.94  ? 476  SER A O   1 
ATOM   234  C  CB  . SER A 1 37  ? 21.473 11.657  57.471 1.00 66.96  ? 476  SER A CB  1 
ATOM   235  O  OG  . SER A 1 37  ? 20.759 11.437  56.266 1.00 69.94  ? 476  SER A OG  1 
ATOM   236  N  N   . GLY A 1 38  ? 22.843 9.571   55.970 1.00 68.30  ? 477  GLY A N   1 
ATOM   237  C  CA  . GLY A 1 38  ? 23.130 8.636   54.905 1.00 68.40  ? 477  GLY A CA  1 
ATOM   238  C  C   . GLY A 1 38  ? 22.671 7.253   55.320 1.00 70.71  ? 477  GLY A C   1 
ATOM   239  O  O   . GLY A 1 38  ? 22.043 7.078   56.367 1.00 71.47  ? 477  GLY A O   1 
ATOM   240  N  N   . THR A 1 39  ? 23.014 6.267   54.489 1.00 70.23  ? 478  THR A N   1 
ATOM   241  C  CA  . THR A 1 39  ? 22.579 4.903   54.768 1.00 71.97  ? 478  THR A CA  1 
ATOM   242  C  C   . THR A 1 39  ? 23.072 4.420   56.130 1.00 72.67  ? 478  THR A C   1 
ATOM   243  O  O   . THR A 1 39  ? 22.458 3.531   56.731 1.00 75.17  ? 478  THR A O   1 
ATOM   244  C  CB  . THR A 1 39  ? 23.046 3.964   53.653 1.00 76.17  ? 478  THR A CB  1 
ATOM   245  O  OG1 . THR A 1 39  ? 24.434 3.652   53.831 1.00 78.63  ? 478  THR A OG1 1 
ATOM   246  C  CG2 . THR A 1 39  ? 22.847 4.613   52.288 1.00 72.66  ? 478  THR A CG2 1 
ATOM   247  N  N   . PHE A 1 40  ? 24.156 5.009   56.644 1.00 71.42  ? 479  PHE A N   1 
ATOM   248  C  CA  . PHE A 1 40  ? 24.682 4.610   57.947 1.00 72.34  ? 479  PHE A CA  1 
ATOM   249  C  C   . PHE A 1 40  ? 23.760 5.030   59.083 1.00 70.23  ? 479  PHE A C   1 
ATOM   250  O  O   . PHE A 1 40  ? 23.663 4.329   60.097 1.00 69.54  ? 479  PHE A O   1 
ATOM   251  C  CB  . PHE A 1 40  ? 26.072 5.211   58.153 1.00 72.63  ? 479  PHE A CB  1 
ATOM   252  C  CG  . PHE A 1 40  ? 26.088 6.716   58.114 1.00 70.72  ? 479  PHE A CG  1 
ATOM   253  C  CD1 . PHE A 1 40  ? 26.149 7.393   56.903 1.00 70.26  ? 479  PHE A CD1 1 
ATOM   254  C  CD2 . PHE A 1 40  ? 26.040 7.452   59.286 1.00 68.17  ? 479  PHE A CD2 1 
ATOM   255  C  CE1 . PHE A 1 40  ? 26.167 8.773   56.866 1.00 67.62  ? 479  PHE A CE1 1 
ATOM   256  C  CE2 . PHE A 1 40  ? 26.055 8.830   59.253 1.00 66.59  ? 479  PHE A CE2 1 
ATOM   257  C  CZ  . PHE A 1 40  ? 26.120 9.491   58.041 1.00 63.93  ? 479  PHE A CZ  1 
ATOM   258  N  N   . GLY A 1 41  ? 23.088 6.149   58.936 1.00 69.45  ? 480  GLY A N   1 
ATOM   259  C  CA  . GLY A 1 41  ? 22.225 6.657   59.969 1.00 69.46  ? 480  GLY A CA  1 
ATOM   260  C  C   . GLY A 1 41  ? 22.059 8.163   59.805 1.00 66.93  ? 480  GLY A C   1 
ATOM   261  O  O   . GLY A 1 41  ? 21.857 8.656   58.693 1.00 64.61  ? 480  GLY A O   1 
ATOM   262  N  N   . LYS A 1 42  ? 22.146 8.875   60.931 1.00 64.35  ? 481  LYS A N   1 
ATOM   263  C  CA  . LYS A 1 42  ? 22.009 10.324  60.941 1.00 64.49  ? 481  LYS A CA  1 
ATOM   264  C  C   . LYS A 1 42  ? 23.044 10.925  61.885 1.00 62.43  ? 481  LYS A C   1 
ATOM   265  O  O   . LYS A 1 42  ? 23.548 10.263  62.797 1.00 62.13  ? 481  LYS A O   1 
ATOM   266  C  CB  . LYS A 1 42  ? 20.596 10.764  61.366 1.00 65.18  ? 481  LYS A CB  1 
ATOM   267  C  CG  . LYS A 1 42  ? 19.468 9.883   60.833 1.00 67.57  ? 481  LYS A CG  1 
ATOM   268  C  CD  . LYS A 1 42  ? 18.151 10.639  60.775 1.00 70.47  ? 481  LYS A CD  1 
ATOM   269  C  CE  . LYS A 1 42  ? 17.080 9.838   60.050 1.00 72.86  ? 481  LYS A CE  1 
ATOM   270  N  NZ  . LYS A 1 42  ? 15.736 10.480  60.143 1.00 74.86  ? 481  LYS A NZ  1 
ATOM   271  N  N   . VAL A 1 43  ? 23.363 12.197  61.645 1.00 60.52  ? 482  VAL A N   1 
ATOM   272  C  CA  . VAL A 1 43  ? 24.287 12.969  62.472 1.00 57.50  ? 482  VAL A CA  1 
ATOM   273  C  C   . VAL A 1 43  ? 23.581 14.246  62.897 1.00 57.45  ? 482  VAL A C   1 
ATOM   274  O  O   . VAL A 1 43  ? 23.093 14.999  62.048 1.00 58.36  ? 482  VAL A O   1 
ATOM   275  C  CB  . VAL A 1 43  ? 25.590 13.310  61.726 1.00 55.93  ? 482  VAL A CB  1 
ATOM   276  C  CG1 . VAL A 1 43  ? 26.545 14.049  62.645 1.00 52.45  ? 482  VAL A CG1 1 
ATOM   277  C  CG2 . VAL A 1 43  ? 26.232 12.048  61.167 1.00 58.36  ? 482  VAL A CG2 1 
ATOM   278  N  N   . VAL A 1 44  ? 23.536 14.498  64.202 1.00 53.44  ? 483  VAL A N   1 
ATOM   279  C  CA  . VAL A 1 44  ? 22.833 15.652  64.744 1.00 55.43  ? 483  VAL A CA  1 
ATOM   280  C  C   . VAL A 1 44  ? 23.788 16.465  65.604 1.00 53.61  ? 483  VAL A C   1 
ATOM   281  O  O   . VAL A 1 44  ? 24.585 15.907  66.366 1.00 53.81  ? 483  VAL A O   1 
ATOM   282  C  CB  . VAL A 1 44  ? 21.591 15.231  65.561 1.00 55.55  ? 483  VAL A CB  1 
ATOM   283  C  CG1 . VAL A 1 44  ? 20.469 14.820  64.630 1.00 57.70  ? 483  VAL A CG1 1 
ATOM   284  C  CG2 . VAL A 1 44  ? 21.931 14.092  66.512 1.00 55.67  ? 483  VAL A CG2 1 
ATOM   285  N  N   . SER A 1 45  ? 23.713 17.785  65.471 1.00 51.45  ? 484  SER A N   1 
ATOM   286  C  CA  . SER A 1 45  ? 24.390 18.663  66.412 1.00 49.74  ? 484  SER A CA  1 
ATOM   287  C  C   . SER A 1 45  ? 23.622 18.681  67.726 1.00 50.61  ? 484  SER A C   1 
ATOM   288  O  O   . SER A 1 45  ? 22.393 18.794  67.733 1.00 54.01  ? 484  SER A O   1 
ATOM   289  C  CB  . SER A 1 45  ? 24.494 20.071  65.842 1.00 49.99  ? 484  SER A CB  1 
ATOM   290  O  OG  . SER A 1 45  ? 24.870 20.963  66.867 1.00 53.51  ? 484  SER A OG  1 
ATOM   291  N  N   . CYS A 1 46  ? 24.335 18.555  68.840 1.00 48.84  ? 485  CYS A N   1 
ATOM   292  C  CA  . CYS A 1 46  ? 23.676 18.359  70.123 1.00 50.36  ? 485  CYS A CA  1 
ATOM   293  C  C   . CYS A 1 46  ? 24.338 19.187  71.212 1.00 49.89  ? 485  CYS A C   1 
ATOM   294  O  O   . CYS A 1 46  ? 25.538 19.469  71.165 1.00 49.18  ? 485  CYS A O   1 
ATOM   295  C  CB  . CYS A 1 46  ? 23.683 16.882  70.543 1.00 50.33  ? 485  CYS A CB  1 
ATOM   296  S  SG  . CYS A 1 46  ? 22.644 15.821  69.526 1.00 55.27  ? 485  CYS A SG  1 
ATOM   297  N  N   . TRP A 1 47  ? 23.534 19.552  72.210 1.00 50.13  ? 486  TRP A N   1 
ATOM   298  C  CA  . TRP A 1 47  ? 24.009 20.230  73.410 1.00 50.70  ? 486  TRP A CA  1 
ATOM   299  C  C   . TRP A 1 47  ? 24.202 19.174  74.493 1.00 52.35  ? 486  TRP A C   1 
ATOM   300  O  O   . TRP A 1 47  ? 23.234 18.551  74.941 1.00 53.82  ? 486  TRP A O   1 
ATOM   301  C  CB  . TRP A 1 47  ? 23.019 21.310  73.843 1.00 50.56  ? 486  TRP A CB  1 
ATOM   302  C  CG  . TRP A 1 47  ? 23.368 22.034  75.124 1.00 51.33  ? 486  TRP A CG  1 
ATOM   303  C  CD1 . TRP A 1 47  ? 22.814 21.831  76.356 1.00 51.53  ? 486  TRP A CD1 1 
ATOM   304  C  CD2 . TRP A 1 47  ? 24.326 23.092  75.287 1.00 49.97  ? 486  TRP A CD2 1 
ATOM   305  N  NE1 . TRP A 1 47  ? 23.374 22.686  77.275 1.00 49.88  ? 486  TRP A NE1 1 
ATOM   306  C  CE2 . TRP A 1 47  ? 24.303 23.470  76.645 1.00 48.94  ? 486  TRP A CE2 1 
ATOM   307  C  CE3 . TRP A 1 47  ? 25.205 23.750  74.419 1.00 51.01  ? 486  TRP A CE3 1 
ATOM   308  C  CZ2 . TRP A 1 47  ? 25.120 24.478  77.154 1.00 49.64  ? 486  TRP A CZ2 1 
ATOM   309  C  CZ3 . TRP A 1 47  ? 26.019 24.749  74.928 1.00 50.27  ? 486  TRP A CZ3 1 
ATOM   310  C  CH2 . TRP A 1 47  ? 25.973 25.102  76.284 1.00 48.49  ? 486  TRP A CH2 1 
ATOM   311  N  N   . ASP A 1 48  ? 25.450 18.954  74.894 1.00 50.32  ? 487  ASP A N   1 
ATOM   312  C  CA  . ASP A 1 48  ? 25.759 18.034  75.984 1.00 51.36  ? 487  ASP A CA  1 
ATOM   313  C  C   . ASP A 1 48  ? 25.320 18.674  77.296 1.00 53.14  ? 487  ASP A C   1 
ATOM   314  O  O   . ASP A 1 48  ? 26.028 19.507  77.859 1.00 51.10  ? 487  ASP A O   1 
ATOM   315  C  CB  . ASP A 1 48  ? 27.249 17.708  75.996 1.00 49.90  ? 487  ASP A CB  1 
ATOM   316  C  CG  . ASP A 1 48  ? 27.594 16.602  76.975 1.00 51.81  ? 487  ASP A CG  1 
ATOM   317  O  OD1 . ASP A 1 48  ? 26.667 16.086  77.631 1.00 54.62  ? 487  ASP A OD1 1 
ATOM   318  O  OD2 . ASP A 1 48  ? 28.786 16.243  77.088 1.00 50.63  ? 487  ASP A OD2 1 
ATOM   319  N  N   A ARG A 1 49  ? 24.146 18.272  77.795 0.50 54.31  ? 488  ARG A N   1 
ATOM   320  N  N   B ARG A 1 49  ? 24.144 18.282  77.793 0.50 54.30  ? 488  ARG A N   1 
ATOM   321  C  CA  A ARG A 1 49  ? 23.601 18.865  79.013 0.50 53.71  ? 488  ARG A CA  1 
ATOM   322  C  CA  B ARG A 1 49  ? 23.608 18.877  79.012 0.50 53.55  ? 488  ARG A CA  1 
ATOM   323  C  C   A ARG A 1 49  ? 24.487 18.627  80.229 0.50 53.45  ? 488  ARG A C   1 
ATOM   324  C  C   B ARG A 1 49  ? 24.483 18.622  80.231 0.50 53.56  ? 488  ARG A C   1 
ATOM   325  O  O   A ARG A 1 49  ? 24.316 19.307  81.245 0.50 55.18  ? 488  ARG A O   1 
ATOM   326  O  O   B ARG A 1 49  ? 24.297 19.289  81.254 0.50 55.19  ? 488  ARG A O   1 
ATOM   327  C  CB  A ARG A 1 49  ? 22.195 18.321  79.281 0.50 54.25  ? 488  ARG A CB  1 
ATOM   328  C  CB  B ARG A 1 49  ? 22.192 18.357  79.272 0.50 54.19  ? 488  ARG A CB  1 
ATOM   329  C  CG  A ARG A 1 49  ? 21.138 18.794  78.288 0.50 55.18  ? 488  ARG A CG  1 
ATOM   330  C  CG  B ARG A 1 49  ? 21.178 18.796  78.227 0.50 55.20  ? 488  ARG A CG  1 
ATOM   331  C  CD  A ARG A 1 49  ? 19.775 18.169  78.568 0.50 55.85  ? 488  ARG A CD  1 
ATOM   332  C  CD  B ARG A 1 49  ? 19.805 18.199  78.488 0.50 55.87  ? 488  ARG A CD  1 
ATOM   333  N  NE  A ARG A 1 49  ? 18.820 18.412  77.488 0.50 55.78  ? 488  ARG A NE  1 
ATOM   334  N  NE  B ARG A 1 49  ? 19.240 18.657  79.753 0.50 56.01  ? 488  ARG A NE  1 
ATOM   335  C  CZ  A ARG A 1 49  ? 17.686 17.736  77.325 0.50 56.66  ? 488  ARG A CZ  1 
ATOM   336  C  CZ  B ARG A 1 49  ? 18.409 19.686  79.872 0.50 55.73  ? 488  ARG A CZ  1 
ATOM   337  N  NH1 A ARG A 1 49  ? 17.358 16.768  78.172 0.50 57.07  ? 488  ARG A NH1 1 
ATOM   338  N  NH1 B ARG A 1 49  ? 18.043 20.371  78.797 0.50 56.97  ? 488  ARG A NH1 1 
ATOM   339  N  NH2 A ARG A 1 49  ? 16.877 18.025  76.313 0.50 55.07  ? 488  ARG A NH2 1 
ATOM   340  N  NH2 B ARG A 1 49  ? 17.946 20.031  81.064 0.50 54.02  ? 488  ARG A NH2 1 
ATOM   341  N  N   . VAL A 1 50  ? 25.430 17.690  80.150 1.00 53.64  ? 489  VAL A N   1 
ATOM   342  C  CA  . VAL A 1 50  ? 26.318 17.423  81.280 1.00 55.02  ? 489  VAL A CA  1 
ATOM   343  C  C   . VAL A 1 50  ? 27.468 18.420  81.308 1.00 55.37  ? 489  VAL A C   1 
ATOM   344  O  O   . VAL A 1 50  ? 27.662 19.142  82.293 1.00 57.86  ? 489  VAL A O   1 
ATOM   345  C  CB  . VAL A 1 50  ? 26.838 15.974  81.230 1.00 55.92  ? 489  VAL A CB  1 
ATOM   346  C  CG1 . VAL A 1 50  ? 28.012 15.801  82.174 1.00 55.27  ? 489  VAL A CG1 1 
ATOM   347  C  CG2 . VAL A 1 50  ? 25.725 14.996  81.575 1.00 55.90  ? 489  VAL A CG2 1 
ATOM   348  N  N   . THR A 1 51  ? 28.256 18.462  80.229 1.00 53.29  ? 490  THR A N   1 
ATOM   349  C  CA  . THR A 1 51  ? 29.396 19.367  80.132 1.00 51.25  ? 490  THR A CA  1 
ATOM   350  C  C   . THR A 1 51  ? 29.006 20.754  79.641 1.00 51.98  ? 490  THR A C   1 
ATOM   351  O  O   . THR A 1 51  ? 29.810 21.686  79.761 1.00 51.53  ? 490  THR A O   1 
ATOM   352  C  CB  . THR A 1 51  ? 30.464 18.778  79.197 1.00 49.72  ? 490  THR A CB  1 
ATOM   353  O  OG1 . THR A 1 51  ? 29.917 18.598  77.884 1.00 48.45  ? 490  THR A OG1 1 
ATOM   354  C  CG2 . THR A 1 51  ? 30.951 17.444  79.715 1.00 48.98  ? 490  THR A CG2 1 
ATOM   355  N  N   . GLU A 1 52  ? 27.798 20.904  79.095 1.00 52.78  ? 491  GLU A N   1 
ATOM   356  C  CA  . GLU A 1 52  ? 27.335 22.159  78.503 1.00 51.06  ? 491  GLU A CA  1 
ATOM   357  C  C   . GLU A 1 52  ? 28.300 22.642  77.422 1.00 52.09  ? 491  GLU A C   1 
ATOM   358  O  O   . GLU A 1 52  ? 28.780 23.778  77.434 1.00 52.31  ? 491  GLU A O   1 
ATOM   359  C  CB  . GLU A 1 52  ? 27.096 23.214  79.581 1.00 50.87  ? 491  GLU A CB  1 
ATOM   360  C  CG  . GLU A 1 52  ? 25.862 22.873  80.391 1.00 52.08  ? 491  GLU A CG  1 
ATOM   361  C  CD  . GLU A 1 52  ? 25.339 24.018  81.225 1.00 50.70  ? 491  GLU A CD  1 
ATOM   362  O  OE1 . GLU A 1 52  ? 25.408 25.187  80.779 1.00 50.92  ? 491  GLU A OE1 1 
ATOM   363  O  OE2 . GLU A 1 52  ? 24.840 23.735  82.332 1.00 50.44  ? 491  GLU A OE2 1 
ATOM   364  N  N   . GLN A 1 53  ? 28.580 21.747  76.477 1.00 52.01  ? 492  GLN A N   1 
ATOM   365  C  CA  . GLN A 1 53  ? 29.402 22.028  75.316 1.00 48.42  ? 492  GLN A CA  1 
ATOM   366  C  C   . GLN A 1 53  ? 28.648 21.590  74.073 1.00 49.30  ? 492  GLN A C   1 
ATOM   367  O  O   . GLN A 1 53  ? 27.668 20.847  74.145 1.00 49.54  ? 492  GLN A O   1 
ATOM   368  C  CB  . GLN A 1 53  ? 30.751 21.302  75.373 1.00 50.74  ? 492  GLN A CB  1 
ATOM   369  C  CG  . GLN A 1 53  ? 31.594 21.628  76.584 1.00 53.50  ? 492  GLN A CG  1 
ATOM   370  C  CD  . GLN A 1 53  ? 32.297 22.964  76.463 1.00 60.62  ? 492  GLN A CD  1 
ATOM   371  O  OE1 . GLN A 1 53  ? 33.454 23.034  76.045 1.00 67.74  ? 492  GLN A OE1 1 
ATOM   372  N  NE2 . GLN A 1 53  ? 31.603 24.036  76.833 1.00 55.32  ? 492  GLN A NE2 1 
ATOM   373  N  N   . LEU A 1 54  ? 29.118 22.060  72.925 1.00 53.36  ? 493  LEU A N   1 
ATOM   374  C  CA  . LEU A 1 54  ? 28.574 21.607  71.656 1.00 50.25  ? 493  LEU A CA  1 
ATOM   375  C  C   . LEU A 1 54  ? 29.246 20.303  71.258 1.00 49.53  ? 493  LEU A C   1 
ATOM   376  O  O   . LEU A 1 54  ? 30.475 20.185  71.309 1.00 50.20  ? 493  LEU A O   1 
ATOM   377  C  CB  . LEU A 1 54  ? 28.781 22.666  70.575 1.00 48.80  ? 493  LEU A CB  1 
ATOM   378  C  CG  . LEU A 1 54  ? 27.756 23.795  70.559 1.00 49.63  ? 493  LEU A CG  1 
ATOM   379  C  CD1 . LEU A 1 54  ? 27.927 24.641  69.313 1.00 50.21  ? 493  LEU A CD1 1 
ATOM   380  C  CD2 . LEU A 1 54  ? 26.361 23.217  70.628 1.00 49.52  ? 493  LEU A CD2 1 
ATOM   381  N  N   . VAL A 1 55  ? 28.440 19.316  70.876 1.00 47.29  ? 494  VAL A N   1 
ATOM   382  C  CA  . VAL A 1 55  ? 28.944 18.030  70.424 1.00 49.21  ? 494  VAL A CA  1 
ATOM   383  C  C   . VAL A 1 55  ? 28.176 17.620  69.175 1.00 48.04  ? 494  VAL A C   1 
ATOM   384  O  O   . VAL A 1 55  ? 27.151 18.205  68.821 1.00 48.24  ? 494  VAL A O   1 
ATOM   385  C  CB  . VAL A 1 55  ? 28.838 16.933  71.508 1.00 48.06  ? 494  VAL A CB  1 
ATOM   386  C  CG1 . VAL A 1 55  ? 29.639 17.312  72.745 1.00 45.53  ? 494  VAL A CG1 1 
ATOM   387  C  CG2 . VAL A 1 55  ? 27.383 16.667  71.863 1.00 47.21  ? 494  VAL A CG2 1 
ATOM   388  N  N   . ALA A 1 56  ? 28.698 16.604  68.500 1.00 46.95  ? 495  ALA A N   1 
ATOM   389  C  CA  . ALA A 1 56  ? 28.015 15.971  67.383 1.00 49.20  ? 495  ALA A CA  1 
ATOM   390  C  C   . ALA A 1 56  ? 27.770 14.514  67.740 1.00 49.87  ? 495  ALA A C   1 
ATOM   391  O  O   . ALA A 1 56  ? 28.672 13.830  68.235 1.00 48.98  ? 495  ALA A O   1 
ATOM   392  C  CB  . ALA A 1 56  ? 28.829 16.086  66.094 1.00 48.31  ? 495  ALA A CB  1 
ATOM   393  N  N   . VAL A 1 57  ? 26.547 14.051  67.515 1.00 50.38  ? 496  VAL A N   1 
ATOM   394  C  CA  . VAL A 1 57  ? 26.170 12.675  67.800 1.00 53.45  ? 496  VAL A CA  1 
ATOM   395  C  C   . VAL A 1 57  ? 25.755 12.018  66.494 1.00 53.91  ? 496  VAL A C   1 
ATOM   396  O  O   . VAL A 1 57  ? 24.903 12.544  65.770 1.00 54.04  ? 496  VAL A O   1 
ATOM   397  C  CB  . VAL A 1 57  ? 25.045 12.593  68.847 1.00 54.39  ? 496  VAL A CB  1 
ATOM   398  C  CG1 . VAL A 1 57  ? 24.821 11.144  69.261 1.00 55.98  ? 496  VAL A CG1 1 
ATOM   399  C  CG2 . VAL A 1 57  ? 25.392 13.440  70.062 1.00 50.31  ? 496  VAL A CG2 1 
ATOM   400  N  N   . LYS A 1 58  ? 26.366 10.876  66.198 1.00 54.14  ? 497  LYS A N   1 
ATOM   401  C  CA  . LYS A 1 58  ? 26.101 10.108  64.988 1.00 57.00  ? 497  LYS A CA  1 
ATOM   402  C  C   . LYS A 1 58  ? 25.297 8.882   65.396 1.00 58.65  ? 497  LYS A C   1 
ATOM   403  O  O   . LYS A 1 58  ? 25.819 7.988   66.069 1.00 59.11  ? 497  LYS A O   1 
ATOM   404  C  CB  . LYS A 1 58  ? 27.411 9.727   64.300 1.00 56.07  ? 497  LYS A CB  1 
ATOM   405  C  CG  . LYS A 1 58  ? 27.309 8.676   63.204 1.00 58.18  ? 497  LYS A CG  1 
ATOM   406  C  CD  . LYS A 1 58  ? 28.681 8.049   62.958 1.00 54.07  ? 497  LYS A CD  1 
ATOM   407  C  CE  . LYS A 1 58  ? 28.909 7.729   61.491 1.00 54.02  ? 497  LYS A CE  1 
ATOM   408  N  NZ  . LYS A 1 58  ? 30.317 7.324   61.217 1.00 50.38  ? 497  LYS A NZ  1 
ATOM   409  N  N   . VAL A 1 59  ? 24.028 8.847   65.003 1.00 62.04  ? 498  VAL A N   1 
ATOM   410  C  CA  . VAL A 1 59  ? 23.120 7.764   65.368 1.00 65.30  ? 498  VAL A CA  1 
ATOM   411  C  C   . VAL A 1 59  ? 23.057 6.780   64.209 1.00 64.13  ? 498  VAL A C   1 
ATOM   412  O  O   . VAL A 1 59  ? 22.609 7.126   63.109 1.00 64.11  ? 498  VAL A O   1 
ATOM   413  C  CB  . VAL A 1 59  ? 21.724 8.295   65.725 1.00 64.51  ? 498  VAL A CB  1 
ATOM   414  C  CG1 . VAL A 1 59  ? 20.850 7.161   66.233 1.00 67.12  ? 498  VAL A CG1 1 
ATOM   415  C  CG2 . VAL A 1 59  ? 21.836 9.390   66.774 1.00 61.27  ? 498  VAL A CG2 1 
ATOM   416  N  N   . ILE A 1 60  ? 23.491 5.560   64.459 1.00 64.11  ? 499  ILE A N   1 
ATOM   417  C  CA  . ILE A 1 60  ? 23.643 4.557   63.414 1.00 69.35  ? 499  ILE A CA  1 
ATOM   418  C  C   . ILE A 1 60  ? 22.335 3.799   63.245 1.00 71.44  ? 499  ILE A C   1 
ATOM   419  O  O   . ILE A 1 60  ? 21.684 3.420   64.228 1.00 71.94  ? 499  ILE A O   1 
ATOM   420  C  CB  . ILE A 1 60  ? 24.814 3.606   63.736 1.00 67.48  ? 499  ILE A CB  1 
ATOM   421  C  CG1 . ILE A 1 60  ? 26.155 4.322   63.559 1.00 64.53  ? 499  ILE A CG1 1 
ATOM   422  C  CG2 . ILE A 1 60  ? 24.780 2.372   62.851 1.00 66.96  ? 499  ILE A CG2 1 
ATOM   423  C  CD1 . ILE A 1 60  ? 26.604 5.092   64.765 1.00 63.50  ? 499  ILE A CD1 1 
ATOM   424  N  N   . ARG A 1 61  ? 21.944 3.595   61.985 1.00 72.38  ? 500  ARG A N   1 
ATOM   425  C  CA  . ARG A 1 61  ? 20.767 2.801   61.651 1.00 74.44  ? 500  ARG A CA  1 
ATOM   426  C  C   . ARG A 1 61  ? 20.850 1.425   62.303 1.00 75.48  ? 500  ARG A C   1 
ATOM   427  O  O   . ARG A 1 61  ? 21.881 0.750   62.241 1.00 73.84  ? 500  ARG A O   1 
ATOM   428  C  CB  . ARG A 1 61  ? 20.647 2.690   60.125 1.00 76.66  ? 500  ARG A CB  1 
ATOM   429  C  CG  . ARG A 1 61  ? 19.416 1.958   59.596 1.00 81.04  ? 500  ARG A CG  1 
ATOM   430  C  CD  . ARG A 1 61  ? 19.608 1.544   58.127 1.00 83.21  ? 500  ARG A CD  1 
ATOM   431  N  NE  . ARG A 1 61  ? 18.866 0.335   57.775 1.00 86.32  ? 500  ARG A NE  1 
ATOM   432  C  CZ  . ARG A 1 61  ? 17.632 0.304   57.279 1.00 88.46  ? 500  ARG A CZ  1 
ATOM   433  N  NH1 . ARG A 1 61  ? 16.971 1.429   57.043 1.00 86.94  ? 500  ARG A NH1 1 
ATOM   434  N  NH2 . ARG A 1 61  ? 17.063 -0.864  57.009 1.00 88.57  ? 500  ARG A NH2 1 
ATOM   435  N  N   . ALA A 1 62  ? 19.765 1.029   62.961 1.00 77.33  ? 501  ALA A N   1 
ATOM   436  C  CA  . ALA A 1 62  ? 19.763 -0.197  63.748 1.00 77.69  ? 501  ALA A CA  1 
ATOM   437  C  C   . ALA A 1 62  ? 19.831 -1.447  62.871 1.00 81.93  ? 501  ALA A C   1 
ATOM   438  O  O   . ALA A 1 62  ? 18.854 -2.195  62.777 1.00 83.71  ? 501  ALA A O   1 
ATOM   439  C  CB  . ALA A 1 62  ? 18.517 -0.241  64.635 1.00 79.71  ? 501  ALA A CB  1 
ATOM   440  N  N   . VAL A 1 63  ? 20.970 -1.673  62.211 1.00 83.23  ? 502  VAL A N   1 
ATOM   441  C  CA  . VAL A 1 63  ? 21.209 -2.864  61.395 1.00 81.09  ? 502  VAL A CA  1 
ATOM   442  C  C   . VAL A 1 63  ? 22.637 -3.334  61.628 1.00 82.64  ? 502  VAL A C   1 
ATOM   443  O  O   . VAL A 1 63  ? 23.564 -2.516  61.701 1.00 81.21  ? 502  VAL A O   1 
ATOM   444  C  CB  . VAL A 1 63  ? 20.978 -2.612  59.892 1.00 79.27  ? 502  VAL A CB  1 
ATOM   445  C  CG1 . VAL A 1 63  ? 20.826 -3.928  59.160 1.00 85.18  ? 502  VAL A CG1 1 
ATOM   446  C  CG2 . VAL A 1 63  ? 19.745 -1.797  59.681 1.00 80.49  ? 502  VAL A CG2 1 
ATOM   447  N  N   . ARG A 1 64  ? 22.818 -4.657  61.702 1.00 84.31  ? 503  ARG A N   1 
ATOM   448  C  CA  . ARG A 1 64  ? 24.111 -5.188  62.114 1.00 82.60  ? 503  ARG A CA  1 
ATOM   449  C  C   . ARG A 1 64  ? 25.159 -4.973  61.034 1.00 81.06  ? 503  ARG A C   1 
ATOM   450  O  O   . ARG A 1 64  ? 26.356 -4.939  61.333 1.00 81.26  ? 503  ARG A O   1 
ATOM   451  C  CB  . ARG A 1 64  ? 23.991 -6.661  62.488 1.00 82.55  ? 503  ARG A CB  1 
ATOM   452  C  CG  . ARG A 1 64  ? 22.992 -6.975  63.617 1.00 86.65  ? 503  ARG A CG  1 
ATOM   453  C  CD  . ARG A 1 64  ? 22.652 -5.749  64.477 1.00 86.63  ? 503  ARG A CD  1 
ATOM   454  N  NE  . ARG A 1 64  ? 23.585 -5.587  65.595 1.00 92.44  ? 503  ARG A NE  1 
ATOM   455  C  CZ  . ARG A 1 64  ? 23.508 -6.252  66.748 1.00 88.76  ? 503  ARG A CZ  1 
ATOM   456  N  NH1 . ARG A 1 64  ? 22.526 -7.118  66.958 1.00 92.66  ? 503  ARG A NH1 1 
ATOM   457  N  NH2 . ARG A 1 64  ? 24.409 -6.048  67.701 1.00 88.85  ? 503  ARG A NH2 1 
ATOM   458  N  N   . LYS A 1 65  ? 24.731 -4.800  59.782 1.00 81.28  ? 504  LYS A N   1 
ATOM   459  C  CA  . LYS A 1 65  ? 25.653 -4.354  58.742 1.00 81.60  ? 504  LYS A CA  1 
ATOM   460  C  C   . LYS A 1 65  ? 26.297 -3.022  59.121 1.00 80.50  ? 504  LYS A C   1 
ATOM   461  O  O   . LYS A 1 65  ? 27.521 -2.859  59.036 1.00 80.71  ? 504  LYS A O   1 
ATOM   462  C  CB  . LYS A 1 65  ? 24.916 -4.248  57.406 1.00 80.56  ? 504  LYS A CB  1 
ATOM   463  C  CG  . LYS A 1 65  ? 25.765 -3.674  56.301 1.00 79.39  ? 504  LYS A CG  1 
ATOM   464  C  CD  . LYS A 1 65  ? 27.080 -4.442  56.164 1.00 79.91  ? 504  LYS A CD  1 
ATOM   465  C  CE  . LYS A 1 65  ? 27.903 -3.933  54.987 1.00 80.06  ? 504  LYS A CE  1 
ATOM   466  N  NZ  . LYS A 1 65  ? 27.738 -2.466  54.780 1.00 74.90  ? 504  LYS A NZ  1 
ATOM   467  N  N   . TYR A 1 66  ? 25.486 -2.061  59.563 1.00 80.09  ? 505  TYR A N   1 
ATOM   468  C  CA  . TYR A 1 66  ? 25.999 -0.763  59.981 1.00 75.25  ? 505  TYR A CA  1 
ATOM   469  C  C   . TYR A 1 66  ? 26.433 -0.739  61.441 1.00 74.02  ? 505  TYR A C   1 
ATOM   470  O  O   . TYR A 1 66  ? 27.340 0.022   61.792 1.00 73.23  ? 505  TYR A O   1 
ATOM   471  C  CB  . TYR A 1 66  ? 24.949 0.324   59.728 1.00 74.52  ? 505  TYR A CB  1 
ATOM   472  C  CG  . TYR A 1 66  ? 24.627 0.496   58.262 1.00 75.51  ? 505  TYR A CG  1 
ATOM   473  C  CD1 . TYR A 1 66  ? 23.461 -0.028  57.722 1.00 79.80  ? 505  TYR A CD1 1 
ATOM   474  C  CD2 . TYR A 1 66  ? 25.502 1.162   57.411 1.00 75.80  ? 505  TYR A CD2 1 
ATOM   475  C  CE1 . TYR A 1 66  ? 23.168 0.115   56.375 1.00 79.57  ? 505  TYR A CE1 1 
ATOM   476  C  CE2 . TYR A 1 66  ? 25.219 1.310   56.065 1.00 75.64  ? 505  TYR A CE2 1 
ATOM   477  C  CZ  . TYR A 1 66  ? 24.051 0.784   55.552 1.00 77.37  ? 505  TYR A CZ  1 
ATOM   478  O  OH  . TYR A 1 66  ? 23.766 0.927   54.213 1.00 74.07  ? 505  TYR A OH  1 
ATOM   479  N  N   . ALA A 1 67  ? 25.822 -1.559  62.299 1.00 74.98  ? 506  ALA A N   1 
ATOM   480  C  CA  . ALA A 1 67  ? 26.228 -1.581  63.702 1.00 73.67  ? 506  ALA A CA  1 
ATOM   481  C  C   . ALA A 1 67  ? 27.618 -2.183  63.867 1.00 72.09  ? 506  ALA A C   1 
ATOM   482  O  O   . ALA A 1 67  ? 28.399 -1.732  64.713 1.00 67.28  ? 506  ALA A O   1 
ATOM   483  C  CB  . ALA A 1 67  ? 25.205 -2.351  64.536 1.00 78.04  ? 506  ALA A CB  1 
ATOM   484  N  N   . GLU A 1 68  ? 27.944 -3.208  63.074 1.00 75.01  ? 507  GLU A N   1 
ATOM   485  C  CA  . GLU A 1 68  ? 29.286 -3.781  63.126 1.00 72.52  ? 507  GLU A CA  1 
ATOM   486  C  C   . GLU A 1 68  ? 30.322 -2.788  62.613 1.00 67.17  ? 507  GLU A C   1 
ATOM   487  O  O   . GLU A 1 68  ? 31.428 -2.694  63.159 1.00 64.03  ? 507  GLU A O   1 
ATOM   488  C  CB  . GLU A 1 68  ? 29.337 -5.081  62.321 1.00 72.26  ? 507  GLU A CB  1 
ATOM   489  C  CG  . GLU A 1 68  ? 29.052 -6.334  63.138 1.00 74.71  ? 507  GLU A CG  1 
ATOM   490  C  CD  . GLU A 1 68  ? 28.471 -7.464  62.301 1.00 81.93  ? 507  GLU A CD  1 
ATOM   491  O  OE1 . GLU A 1 68  ? 27.247 -7.453  62.046 1.00 82.51  ? 507  GLU A OE1 1 
ATOM   492  O  OE2 . GLU A 1 68  ? 29.237 -8.366  61.899 1.00 83.27  ? 507  GLU A OE2 1 
ATOM   493  N  N   . ALA A 1 69  ? 29.982 -2.039  61.564 1.00 69.10  ? 508  ALA A N   1 
ATOM   494  C  CA  . ALA A 1 69  ? 30.883 -0.998  61.088 1.00 66.55  ? 508  ALA A CA  1 
ATOM   495  C  C   . ALA A 1 69  ? 31.060 0.089   62.138 1.00 64.62  ? 508  ALA A C   1 
ATOM   496  O  O   . ALA A 1 69  ? 32.168 0.602   62.333 1.00 62.84  ? 508  ALA A O   1 
ATOM   497  C  CB  . ALA A 1 69  ? 30.358 -0.407  59.779 1.00 66.55  ? 508  ALA A CB  1 
ATOM   498  N  N   . ALA A 1 70  ? 29.977 0.438   62.838 1.00 66.01  ? 509  ALA A N   1 
ATOM   499  C  CA  . ALA A 1 70  ? 30.045 1.492   63.843 1.00 63.01  ? 509  ALA A CA  1 
ATOM   500  C  C   . ALA A 1 70  ? 30.995 1.121   64.974 1.00 61.24  ? 509  ALA A C   1 
ATOM   501  O  O   . ALA A 1 70  ? 31.789 1.955   65.423 1.00 59.64  ? 509  ALA A O   1 
ATOM   502  C  CB  . ALA A 1 70  ? 28.648 1.787   64.389 1.00 65.25  ? 509  ALA A CB  1 
ATOM   503  N  N   . ARG A 1 71  ? 30.933 -0.125  65.450 1.00 59.55  ? 510  ARG A N   1 
ATOM   504  C  CA  . ARG A 1 71  ? 31.835 -0.517  66.526 1.00 62.57  ? 510  ARG A CA  1 
ATOM   505  C  C   . ARG A 1 71  ? 33.269 -0.643  66.028 1.00 61.60  ? 510  ARG A C   1 
ATOM   506  O  O   . ARG A 1 71  ? 34.214 -0.446  66.802 1.00 59.75  ? 510  ARG A O   1 
ATOM   507  C  CB  . ARG A 1 71  ? 31.368 -1.823  67.169 1.00 67.45  ? 510  ARG A CB  1 
ATOM   508  C  CG  . ARG A 1 71  ? 32.008 -2.098  68.532 1.00 72.41  ? 510  ARG A CG  1 
ATOM   509  C  CD  . ARG A 1 71  ? 31.548 -3.425  69.121 1.00 75.10  ? 510  ARG A CD  1 
ATOM   510  N  NE  . ARG A 1 71  ? 32.643 -4.138  69.779 1.00 77.17  ? 510  ARG A NE  1 
ATOM   511  C  CZ  . ARG A 1 71  ? 33.208 -5.244  69.302 1.00 76.72  ? 510  ARG A CZ  1 
ATOM   512  N  NH1 . ARG A 1 71  ? 32.781 -5.769  68.161 1.00 75.74  ? 510  ARG A NH1 1 
ATOM   513  N  NH2 . ARG A 1 71  ? 34.199 -5.827  69.966 1.00 78.02  ? 510  ARG A NH2 1 
ATOM   514  N  N   . MET A 1 72  ? 33.455 -0.959  64.744 1.00 60.85  ? 511  MET A N   1 
ATOM   515  C  CA  . MET A 1 72  ? 34.792 -0.894  64.165 1.00 59.71  ? 511  MET A CA  1 
ATOM   516  C  C   . MET A 1 72  ? 35.325 0.533   64.197 1.00 57.06  ? 511  MET A C   1 
ATOM   517  O  O   . MET A 1 72  ? 36.509 0.757   64.473 1.00 54.56  ? 511  MET A O   1 
ATOM   518  C  CB  . MET A 1 72  ? 34.772 -1.431  62.734 1.00 62.63  ? 511  MET A CB  1 
ATOM   519  C  CG  . MET A 1 72  ? 36.084 -1.254  61.982 1.00 60.83  ? 511  MET A CG  1 
ATOM   520  S  SD  . MET A 1 72  ? 37.269 -2.588  62.278 1.00 71.68  ? 511  MET A SD  1 
ATOM   521  C  CE  . MET A 1 72  ? 38.217 -1.951  63.659 1.00 56.47  ? 511  MET A CE  1 
ATOM   522  N  N   . GLU A 1 73  ? 34.455 1.512   63.929 1.00 55.36  ? 512  GLU A N   1 
ATOM   523  C  CA  . GLU A 1 73  ? 34.860 2.912   64.002 1.00 52.96  ? 512  GLU A CA  1 
ATOM   524  C  C   . GLU A 1 73  ? 35.164 3.327   65.436 1.00 53.40  ? 512  GLU A C   1 
ATOM   525  O  O   . GLU A 1 73  ? 36.099 4.099   65.679 1.00 51.52  ? 512  GLU A O   1 
ATOM   526  C  CB  . GLU A 1 73  ? 33.772 3.804   63.408 1.00 50.32  ? 512  GLU A CB  1 
ATOM   527  C  CG  . GLU A 1 73  ? 34.089 5.283   63.498 1.00 51.83  ? 512  GLU A CG  1 
ATOM   528  C  CD  . GLU A 1 73  ? 33.171 6.132   62.647 1.00 52.01  ? 512  GLU A CD  1 
ATOM   529  O  OE1 . GLU A 1 73  ? 33.567 7.265   62.292 1.00 50.61  ? 512  GLU A OE1 1 
ATOM   530  O  OE2 . GLU A 1 73  ? 32.053 5.666   62.334 1.00 54.05  ? 512  GLU A OE2 1 
ATOM   531  N  N   . ILE A 1 74  ? 34.375 2.836   66.397 1.00 53.04  ? 513  ILE A N   1 
ATOM   532  C  CA  . ILE A 1 74  ? 34.662 3.096   67.805 1.00 52.96  ? 513  ILE A CA  1 
ATOM   533  C  C   . ILE A 1 74  ? 36.023 2.527   68.180 1.00 53.38  ? 513  ILE A C   1 
ATOM   534  O  O   . ILE A 1 74  ? 36.830 3.187   68.849 1.00 51.91  ? 513  ILE A O   1 
ATOM   535  C  CB  . ILE A 1 74  ? 33.544 2.514   68.690 1.00 55.47  ? 513  ILE A CB  1 
ATOM   536  C  CG1 . ILE A 1 74  ? 32.251 3.303   68.494 1.00 55.63  ? 513  ILE A CG1 1 
ATOM   537  C  CG2 . ILE A 1 74  ? 33.955 2.516   70.151 1.00 54.00  ? 513  ILE A CG2 1 
ATOM   538  C  CD1 . ILE A 1 74  ? 31.091 2.759   69.277 1.00 57.14  ? 513  ILE A CD1 1 
ATOM   539  N  N   . ASP A 1 75  ? 36.300 1.296   67.740 1.00 54.12  ? 514  ASP A N   1 
ATOM   540  C  CA  . ASP A 1 75  ? 37.570 0.642   68.041 1.00 54.74  ? 514  ASP A CA  1 
ATOM   541  C  C   . ASP A 1 75  ? 38.756 1.452   67.531 1.00 52.69  ? 514  ASP A C   1 
ATOM   542  O  O   . ASP A 1 75  ? 39.779 1.566   68.215 1.00 51.76  ? 514  ASP A O   1 
ATOM   543  C  CB  . ASP A 1 75  ? 37.580 -0.760  67.430 1.00 55.49  ? 514  ASP A CB  1 
ATOM   544  C  CG  . ASP A 1 75  ? 38.849 -1.521  67.738 1.00 58.76  ? 514  ASP A CG  1 
ATOM   545  O  OD1 . ASP A 1 75  ? 39.039 -1.915  68.908 1.00 63.53  ? 514  ASP A OD1 1 
ATOM   546  O  OD2 . ASP A 1 75  ? 39.661 -1.718  66.811 1.00 61.73  ? 514  ASP A OD2 1 
ATOM   547  N  N   . ILE A 1 76  ? 38.640 2.014   66.328 1.00 53.46  ? 515  ILE A N   1 
ATOM   548  C  CA  . ILE A 1 76  ? 39.735 2.787   65.750 1.00 50.59  ? 515  ILE A CA  1 
ATOM   549  C  C   . ILE A 1 76  ? 39.849 4.148   66.423 1.00 50.17  ? 515  ILE A C   1 
ATOM   550  O  O   . ILE A 1 76  ? 40.944 4.579   66.805 1.00 49.26  ? 515  ILE A O   1 
ATOM   551  C  CB  . ILE A 1 76  ? 39.545 2.920   64.227 1.00 48.46  ? 515  ILE A CB  1 
ATOM   552  C  CG1 . ILE A 1 76  ? 39.869 1.597   63.539 1.00 47.93  ? 515  ILE A CG1 1 
ATOM   553  C  CG2 . ILE A 1 76  ? 40.416 4.034   63.671 1.00 45.29  ? 515  ILE A CG2 1 
ATOM   554  C  CD1 . ILE A 1 76  ? 39.015 1.326   62.341 1.00 48.07  ? 515  ILE A CD1 1 
ATOM   555  N  N   . LEU A 1 77  ? 38.724 4.847   66.590 1.00 51.19  ? 516  LEU A N   1 
ATOM   556  C  CA  . LEU A 1 77  ? 38.792 6.198   67.134 1.00 51.30  ? 516  LEU A CA  1 
ATOM   557  C  C   . LEU A 1 77  ? 39.254 6.195   68.582 1.00 50.89  ? 516  LEU A C   1 
ATOM   558  O  O   . LEU A 1 77  ? 39.811 7.193   69.053 1.00 50.30  ? 516  LEU A O   1 
ATOM   559  C  CB  . LEU A 1 77  ? 37.438 6.886   67.002 1.00 50.91  ? 516  LEU A CB  1 
ATOM   560  C  CG  . LEU A 1 77  ? 37.091 7.272   65.568 1.00 48.34  ? 516  LEU A CG  1 
ATOM   561  C  CD1 . LEU A 1 77  ? 35.683 7.814   65.499 1.00 52.22  ? 516  LEU A CD1 1 
ATOM   562  C  CD2 . LEU A 1 77  ? 38.079 8.291   65.057 1.00 47.37  ? 516  LEU A CD2 1 
ATOM   563  N  N   . LEU A 1 78  ? 39.040 5.090   69.299 1.00 50.06  ? 517  LEU A N   1 
ATOM   564  C  CA  . LEU A 1 78  ? 39.564 4.986   70.656 1.00 48.79  ? 517  LEU A CA  1 
ATOM   565  C  C   . LEU A 1 78  ? 41.087 4.996   70.655 1.00 49.70  ? 517  LEU A C   1 
ATOM   566  O  O   . LEU A 1 78  ? 41.711 5.628   71.516 1.00 49.90  ? 517  LEU A O   1 
ATOM   567  C  CB  . LEU A 1 78  ? 39.032 3.721   71.328 1.00 51.10  ? 517  LEU A CB  1 
ATOM   568  C  CG  . LEU A 1 78  ? 37.769 3.872   72.178 1.00 51.96  ? 517  LEU A CG  1 
ATOM   569  C  CD1 . LEU A 1 78  ? 37.215 2.505   72.561 1.00 53.50  ? 517  LEU A CD1 1 
ATOM   570  C  CD2 . LEU A 1 78  ? 38.056 4.710   73.414 1.00 47.00  ? 517  LEU A CD2 1 
ATOM   571  N  N   . GLU A 1 79  ? 41.703 4.311   69.687 1.00 50.48  ? 518  GLU A N   1 
ATOM   572  C  CA  . GLU A 1 79  ? 43.161 4.285   69.598 1.00 50.68  ? 518  GLU A CA  1 
ATOM   573  C  C   . GLU A 1 79  ? 43.710 5.627   69.130 1.00 51.31  ? 518  GLU A C   1 
ATOM   574  O  O   . GLU A 1 79  ? 44.685 6.146   69.691 1.00 50.60  ? 518  GLU A O   1 
ATOM   575  C  CB  . GLU A 1 79  ? 43.611 3.167   68.657 1.00 50.51  ? 518  GLU A CB  1 
ATOM   576  C  CG  . GLU A 1 79  ? 45.120 3.097   68.467 1.00 53.21  ? 518  GLU A CG  1 
ATOM   577  C  CD  . GLU A 1 79  ? 45.544 1.967   67.546 1.00 55.83  ? 518  GLU A CD  1 
ATOM   578  O  OE1 . GLU A 1 79  ? 44.655 1.332   66.936 1.00 56.19  ? 518  GLU A OE1 1 
ATOM   579  O  OE2 . GLU A 1 79  ? 46.765 1.715   67.434 1.00 53.24  ? 518  GLU A OE2 1 
ATOM   580  N  N   . LEU A 1 80  ? 43.100 6.200   68.090 1.00 51.53  ? 519  LEU A N   1 
ATOM   581  C  CA  . LEU A 1 80  ? 43.556 7.486   67.577 1.00 48.68  ? 519  LEU A CA  1 
ATOM   582  C  C   . LEU A 1 80  ? 43.427 8.572   68.636 1.00 47.77  ? 519  LEU A C   1 
ATOM   583  O  O   . LEU A 1 80  ? 44.292 9.446   68.749 1.00 48.97  ? 519  LEU A O   1 
ATOM   584  C  CB  . LEU A 1 80  ? 42.764 7.858   66.320 1.00 48.12  ? 519  LEU A CB  1 
ATOM   585  C  CG  . LEU A 1 80  ? 43.244 7.351   64.953 1.00 47.50  ? 519  LEU A CG  1 
ATOM   586  C  CD1 . LEU A 1 80  ? 43.690 5.902   64.999 1.00 45.82  ? 519  LEU A CD1 1 
ATOM   587  C  CD2 . LEU A 1 80  ? 42.155 7.525   63.910 1.00 46.20  ? 519  LEU A CD2 1 
ATOM   588  N  N   . GLY A 1 81  ? 42.355 8.526   69.429 1.00 46.72  ? 520  GLY A N   1 
ATOM   589  C  CA  . GLY A 1 81  ? 42.178 9.518   70.474 1.00 50.01  ? 520  GLY A CA  1 
ATOM   590  C  C   . GLY A 1 81  ? 43.206 9.412   71.582 1.00 52.48  ? 520  GLY A C   1 
ATOM   591  O  O   . GLY A 1 81  ? 43.594 10.428  72.169 1.00 49.80  ? 520  GLY A O   1 
ATOM   592  N  N   . ARG A 1 82  ? 43.665 8.191   71.882 1.00 50.25  ? 521  ARG A N   1 
ATOM   593  C  CA  . ARG A 1 82  ? 44.642 8.007   72.953 1.00 50.60  ? 521  ARG A CA  1 
ATOM   594  C  C   . ARG A 1 82  ? 46.022 8.498   72.539 1.00 51.37  ? 521  ARG A C   1 
ATOM   595  O  O   . ARG A 1 82  ? 46.716 9.154   73.326 1.00 52.09  ? 521  ARG A O   1 
ATOM   596  C  CB  . ARG A 1 82  ? 44.711 6.537   73.365 1.00 51.89  ? 521  ARG A CB  1 
ATOM   597  C  CG  . ARG A 1 82  ? 45.982 6.195   74.141 1.00 54.29  ? 521  ARG A CG  1 
ATOM   598  C  CD  . ARG A 1 82  ? 45.978 4.763   74.645 1.00 57.35  ? 521  ARG A CD  1 
ATOM   599  N  NE  . ARG A 1 82  ? 45.503 3.828   73.629 1.00 56.69  ? 521  ARG A NE  1 
ATOM   600  C  CZ  . ARG A 1 82  ? 46.264 3.327   72.661 1.00 55.06  ? 521  ARG A CZ  1 
ATOM   601  N  NH1 . ARG A 1 82  ? 47.543 3.669   72.572 1.00 53.81  ? 521  ARG A NH1 1 
ATOM   602  N  NH2 . ARG A 1 82  ? 45.742 2.482   71.782 1.00 57.02  ? 521  ARG A NH2 1 
ATOM   603  N  N   . LYS A 1 83  ? 46.444 8.183   71.312 1.00 50.29  ? 522  LYS A N   1 
ATOM   604  C  CA  . LYS A 1 83  ? 47.748 8.642   70.849 1.00 48.43  ? 522  LYS A CA  1 
ATOM   605  C  C   . LYS A 1 83  ? 47.730 10.130  70.533 1.00 49.80  ? 522  LYS A C   1 
ATOM   606  O  O   . LYS A 1 83  ? 48.684 10.849  70.849 1.00 52.83  ? 522  LYS A O   1 
ATOM   607  C  CB  . LYS A 1 83  ? 48.181 7.846   69.622 1.00 49.43  ? 522  LYS A CB  1 
ATOM   608  C  CG  . LYS A 1 83  ? 48.229 6.349   69.840 1.00 50.51  ? 522  LYS A CG  1 
ATOM   609  C  CD  . LYS A 1 83  ? 49.120 5.693   68.804 1.00 53.50  ? 522  LYS A CD  1 
ATOM   610  C  CE  . LYS A 1 83  ? 49.026 4.176   68.857 1.00 54.70  ? 522  LYS A CE  1 
ATOM   611  N  NZ  . LYS A 1 83  ? 49.854 3.543   67.790 1.00 54.74  ? 522  LYS A NZ  1 
ATOM   612  N  N   . ASP A 1 84  ? 46.653 10.613  69.920 1.00 48.61  ? 523  ASP A N   1 
ATOM   613  C  CA  . ASP A 1 84  ? 46.568 11.986  69.425 1.00 48.72  ? 523  ASP A CA  1 
ATOM   614  C  C   . ASP A 1 84  ? 45.328 12.648  70.011 1.00 50.96  ? 523  ASP A C   1 
ATOM   615  O  O   . ASP A 1 84  ? 44.323 12.842  69.313 1.00 51.79  ? 523  ASP A O   1 
ATOM   616  C  CB  . ASP A 1 84  ? 46.544 12.003  67.896 1.00 46.35  ? 523  ASP A CB  1 
ATOM   617  C  CG  . ASP A 1 84  ? 46.644 13.395  67.327 1.00 49.48  ? 523  ASP A CG  1 
ATOM   618  O  OD1 . ASP A 1 84  ? 47.004 14.325  68.080 1.00 49.62  ? 523  ASP A OD1 1 
ATOM   619  O  OD2 . ASP A 1 84  ? 46.352 13.561  66.122 1.00 49.44  ? 523  ASP A OD2 1 
ATOM   620  N  N   . PRO A 1 85  ? 45.371 13.026  71.295 1.00 51.91  ? 524  PRO A N   1 
ATOM   621  C  CA  . PRO A 1 85  ? 44.164 13.592  71.926 1.00 49.13  ? 524  PRO A CA  1 
ATOM   622  C  C   . PRO A 1 85  ? 43.748 14.936  71.354 1.00 52.85  ? 524  PRO A C   1 
ATOM   623  O  O   . PRO A 1 85  ? 42.546 15.181  71.186 1.00 51.50  ? 524  PRO A O   1 
ATOM   624  C  CB  . PRO A 1 85  ? 44.564 13.711  73.405 1.00 51.38  ? 524  PRO A CB  1 
ATOM   625  C  CG  . PRO A 1 85  ? 45.802 12.875  73.559 1.00 51.58  ? 524  PRO A CG  1 
ATOM   626  C  CD  . PRO A 1 85  ? 46.494 12.936  72.239 1.00 52.42  ? 524  PRO A CD  1 
ATOM   627  N  N   . THR A 1 86  ? 44.700 15.825  71.064 1.00 51.39  ? 525  THR A N   1 
ATOM   628  C  CA  . THR A 1 86  ? 44.382 17.135  70.509 1.00 50.30  ? 525  THR A CA  1 
ATOM   629  C  C   . THR A 1 86  ? 44.263 17.118  68.994 1.00 51.20  ? 525  THR A C   1 
ATOM   630  O  O   . THR A 1 86  ? 44.259 18.189  68.377 1.00 51.26  ? 525  THR A O   1 
ATOM   631  C  CB  . THR A 1 86  ? 45.436 18.170  70.910 1.00 50.14  ? 525  THR A CB  1 
ATOM   632  O  OG1 . THR A 1 86  ? 46.744 17.644  70.653 1.00 54.75  ? 525  THR A OG1 1 
ATOM   633  C  CG2 . THR A 1 86  ? 45.298 18.542  72.380 1.00 48.16  ? 525  THR A CG2 1 
ATOM   634  N  N   . SER A 1 87  ? 44.184 15.932  68.386 1.00 50.09  ? 526  SER A N   1 
ATOM   635  C  CA  . SER A 1 87  ? 44.021 15.790  66.938 1.00 49.37  ? 526  SER A CA  1 
ATOM   636  C  C   . SER A 1 87  ? 45.114 16.527  66.169 1.00 47.13  ? 526  SER A C   1 
ATOM   637  O  O   . SER A 1 87  ? 44.846 17.202  65.174 1.00 47.24  ? 526  SER A O   1 
ATOM   638  C  CB  . SER A 1 87  ? 42.636 16.257  66.488 1.00 48.18  ? 526  SER A CB  1 
ATOM   639  O  OG  . SER A 1 87  ? 41.648 15.299  66.828 1.00 49.75  ? 526  SER A OG  1 
ATOM   640  N  N   . ARG A 1 88  ? 46.360 16.397  66.635 1.00 48.13  ? 527  ARG A N   1 
ATOM   641  C  CA  . ARG A 1 88  ? 47.488 16.945  65.889 1.00 48.63  ? 527  ARG A CA  1 
ATOM   642  C  C   . ARG A 1 88  ? 47.510 16.426  64.460 1.00 48.42  ? 527  ARG A C   1 
ATOM   643  O  O   . ARG A 1 88  ? 47.904 17.150  63.537 1.00 48.75  ? 527  ARG A O   1 
ATOM   644  C  CB  . ARG A 1 88  ? 48.804 16.598  66.586 1.00 52.59  ? 527  ARG A CB  1 
ATOM   645  C  CG  . ARG A 1 88  ? 49.341 17.672  67.516 1.00 57.40  ? 527  ARG A CG  1 
ATOM   646  C  CD  . ARG A 1 88  ? 50.560 17.163  68.283 1.00 61.69  ? 527  ARG A CD  1 
ATOM   647  N  NE  . ARG A 1 88  ? 51.737 17.032  67.425 1.00 66.38  ? 527  ARG A NE  1 
ATOM   648  C  CZ  . ARG A 1 88  ? 52.676 16.100  67.568 1.00 67.92  ? 527  ARG A CZ  1 
ATOM   649  N  NH1 . ARG A 1 88  ? 52.585 15.197  68.540 1.00 66.29  ? 527  ARG A NH1 1 
ATOM   650  N  NH2 . ARG A 1 88  ? 53.710 16.066  66.734 1.00 66.20  ? 527  ARG A NH2 1 
ATOM   651  N  N   . PHE A 1 89  ? 47.084 15.181  64.255 1.00 46.55  ? 528  PHE A N   1 
ATOM   652  C  CA  . PHE A 1 89  ? 47.100 14.551  62.945 1.00 46.89  ? 528  PHE A CA  1 
ATOM   653  C  C   . PHE A 1 89  ? 45.738 14.593  62.252 1.00 45.63  ? 528  PHE A C   1 
ATOM   654  O  O   . PHE A 1 89  ? 45.502 13.819  61.322 1.00 47.19  ? 528  PHE A O   1 
ATOM   655  C  CB  . PHE A 1 89  ? 47.601 13.114  63.067 1.00 47.67  ? 528  PHE A CB  1 
ATOM   656  C  CG  . PHE A 1 89  ? 49.035 13.011  63.507 1.00 49.93  ? 528  PHE A CG  1 
ATOM   657  C  CD1 . PHE A 1 89  ? 50.065 13.118  62.585 1.00 51.22  ? 528  PHE A CD1 1 
ATOM   658  C  CD2 . PHE A 1 89  ? 49.356 12.815  64.843 1.00 50.20  ? 528  PHE A CD2 1 
ATOM   659  C  CE1 . PHE A 1 89  ? 51.389 13.025  62.986 1.00 54.77  ? 528  PHE A CE1 1 
ATOM   660  C  CE2 . PHE A 1 89  ? 50.675 12.726  65.250 1.00 52.83  ? 528  PHE A CE2 1 
ATOM   661  C  CZ  . PHE A 1 89  ? 51.692 12.831  64.320 1.00 56.81  ? 528  PHE A CZ  1 
ATOM   662  N  N   . HIS A 1 90  ? 44.829 15.452  62.712 1.00 43.17  ? 529  HIS A N   1 
ATOM   663  C  CA  . HIS A 1 90  ? 43.658 15.880  61.954 1.00 44.26  ? 529  HIS A CA  1 
ATOM   664  C  C   . HIS A 1 90  ? 42.628 14.780  61.706 1.00 46.03  ? 529  HIS A C   1 
ATOM   665  O  O   . HIS A 1 90  ? 41.818 14.904  60.784 1.00 47.57  ? 529  HIS A O   1 
ATOM   666  C  CB  . HIS A 1 90  ? 44.074 16.493  60.611 1.00 42.91  ? 529  HIS A CB  1 
ATOM   667  C  CG  . HIS A 1 90  ? 45.167 17.506  60.729 1.00 47.02  ? 529  HIS A CG  1 
ATOM   668  N  ND1 . HIS A 1 90  ? 44.938 18.798  61.153 1.00 48.35  ? 529  HIS A ND1 1 
ATOM   669  C  CD2 . HIS A 1 90  ? 46.496 17.419  60.483 1.00 46.34  ? 529  HIS A CD2 1 
ATOM   670  C  CE1 . HIS A 1 90  ? 46.079 19.464  61.161 1.00 49.75  ? 529  HIS A CE1 1 
ATOM   671  N  NE2 . HIS A 1 90  ? 47.039 18.650  60.759 1.00 49.37  ? 529  HIS A NE2 1 
ATOM   672  N  N   . CYS A 1 91  ? 42.627 13.692  62.474 1.00 42.54  ? 530  CYS A N   1 
ATOM   673  C  CA  . CYS A 1 91  ? 41.485 12.784  62.445 1.00 43.22  ? 530  CYS A CA  1 
ATOM   674  C  C   . CYS A 1 91  ? 40.466 13.187  63.503 1.00 44.32  ? 530  CYS A C   1 
ATOM   675  O  O   . CYS A 1 91  ? 40.811 13.751  64.545 1.00 44.44  ? 530  CYS A O   1 
ATOM   676  C  CB  . CYS A 1 91  ? 41.888 11.317  62.633 1.00 42.46  ? 530  CYS A CB  1 
ATOM   677  S  SG  . CYS A 1 91  ? 43.358 10.718  61.736 1.00 48.36  ? 530  CYS A SG  1 
ATOM   678  N  N   . VAL A 1 92  ? 39.195 12.881  63.219 1.00 45.65  ? 531  VAL A N   1 
ATOM   679  C  CA  . VAL A 1 92  ? 38.109 13.376  64.054 1.00 46.54  ? 531  VAL A CA  1 
ATOM   680  C  C   . VAL A 1 92  ? 38.205 12.779  65.451 1.00 47.22  ? 531  VAL A C   1 
ATOM   681  O  O   . VAL A 1 92  ? 38.582 11.614  65.636 1.00 45.46  ? 531  VAL A O   1 
ATOM   682  C  CB  . VAL A 1 92  ? 36.745 13.082  63.407 1.00 47.11  ? 531  VAL A CB  1 
ATOM   683  C  CG1 . VAL A 1 92  ? 36.410 11.594  63.482 1.00 44.36  ? 531  VAL A CG1 1 
ATOM   684  C  CG2 . VAL A 1 92  ? 35.652 13.929  64.067 1.00 44.35  ? 531  VAL A CG2 1 
ATOM   685  N  N   . ARG A 1 93  ? 37.889 13.597  66.447 1.00 46.93  ? 532  ARG A N   1 
ATOM   686  C  CA  . ARG A 1 93  ? 37.991 13.201  67.841 1.00 47.92  ? 532  ARG A CA  1 
ATOM   687  C  C   . ARG A 1 93  ? 36.648 12.644  68.302 1.00 48.08  ? 532  ARG A C   1 
ATOM   688  O  O   . ARG A 1 93  ? 35.628 13.341  68.245 1.00 48.58  ? 532  ARG A O   1 
ATOM   689  C  CB  . ARG A 1 93  ? 38.420 14.396  68.694 1.00 48.08  ? 532  ARG A CB  1 
ATOM   690  C  CG  . ARG A 1 93  ? 38.852 14.049  70.102 1.00 50.34  ? 532  ARG A CG  1 
ATOM   691  C  CD  . ARG A 1 93  ? 39.923 12.971  70.112 1.00 50.98  ? 532  ARG A CD  1 
ATOM   692  N  NE  . ARG A 1 93  ? 40.551 12.863  71.426 1.00 56.23  ? 532  ARG A NE  1 
ATOM   693  C  CZ  . ARG A 1 93  ? 40.091 12.106  72.418 1.00 55.84  ? 532  ARG A CZ  1 
ATOM   694  N  NH1 . ARG A 1 93  ? 38.996 11.374  72.250 1.00 54.29  ? 532  ARG A NH1 1 
ATOM   695  N  NH2 . ARG A 1 93  ? 40.733 12.075  73.581 1.00 56.55  ? 532  ARG A NH2 1 
ATOM   696  N  N   . MET A 1 94  ? 36.644 11.386  68.734 1.00 49.07  ? 533  MET A N   1 
ATOM   697  C  CA  . MET A 1 94  ? 35.465 10.781  69.340 1.00 50.57  ? 533  MET A CA  1 
ATOM   698  C  C   . MET A 1 94  ? 35.538 10.984  70.849 1.00 51.17  ? 533  MET A C   1 
ATOM   699  O  O   . MET A 1 94  ? 36.502 10.553  71.492 1.00 51.85  ? 533  MET A O   1 
ATOM   700  C  CB  . MET A 1 94  ? 35.359 9.292   69.001 1.00 48.63  ? 533  MET A CB  1 
ATOM   701  C  CG  . MET A 1 94  ? 34.118 8.635   69.595 1.00 50.76  ? 533  MET A CG  1 
ATOM   702  S  SD  . MET A 1 94  ? 34.068 6.828   69.552 1.00 52.14  ? 533  MET A SD  1 
ATOM   703  C  CE  . MET A 1 94  ? 35.460 6.425   70.602 1.00 50.25  ? 533  MET A CE  1 
ATOM   704  N  N   . LEU A 1 95  ? 34.526 11.645  71.409 1.00 49.95  ? 534  LEU A N   1 
ATOM   705  C  CA  . LEU A 1 95  ? 34.498 11.927  72.840 1.00 53.05  ? 534  LEU A CA  1 
ATOM   706  C  C   . LEU A 1 95  ? 33.885 10.791  73.653 1.00 54.30  ? 534  LEU A C   1 
ATOM   707  O  O   . LEU A 1 95  ? 34.395 10.450  74.727 1.00 54.86  ? 534  LEU A O   1 
ATOM   708  C  CB  . LEU A 1 95  ? 33.722 13.221  73.102 1.00 50.98  ? 534  LEU A CB  1 
ATOM   709  C  CG  . LEU A 1 95  ? 34.122 14.431  72.257 1.00 48.86  ? 534  LEU A CG  1 
ATOM   710  C  CD1 . LEU A 1 95  ? 33.209 15.607  72.552 1.00 48.91  ? 534  LEU A CD1 1 
ATOM   711  C  CD2 . LEU A 1 95  ? 35.568 14.794  72.518 1.00 47.35  ? 534  LEU A CD2 1 
ATOM   712  N  N   . SER A 1 96  ? 32.805 10.195  73.159 1.00 52.33  ? 535  SER A N   1 
ATOM   713  C  CA  . SER A 1 96  ? 32.030 9.236   73.928 1.00 53.84  ? 535  SER A CA  1 
ATOM   714  C  C   . SER A 1 96  ? 31.347 8.277   72.963 1.00 55.61  ? 535  SER A C   1 
ATOM   715  O  O   . SER A 1 96  ? 31.371 8.466   71.744 1.00 52.14  ? 535  SER A O   1 
ATOM   716  C  CB  . SER A 1 96  ? 31.010 9.956   74.825 1.00 53.52  ? 535  SER A CB  1 
ATOM   717  O  OG  . SER A 1 96  ? 30.052 9.064   75.366 1.00 54.33  ? 535  SER A OG  1 
ATOM   718  N  N   . TYR A 1 97  ? 30.754 7.225   73.523 1.00 56.42  ? 536  TYR A N   1 
ATOM   719  C  CA  . TYR A 1 97  ? 29.906 6.332   72.748 1.00 57.69  ? 536  TYR A CA  1 
ATOM   720  C  C   . TYR A 1 97  ? 28.955 5.629   73.705 1.00 57.19  ? 536  TYR A C   1 
ATOM   721  O  O   . TYR A 1 97  ? 29.325 5.322   74.840 1.00 58.41  ? 536  TYR A O   1 
ATOM   722  C  CB  . TYR A 1 97  ? 30.724 5.314   71.934 1.00 56.77  ? 536  TYR A CB  1 
ATOM   723  C  CG  . TYR A 1 97  ? 31.688 4.463   72.733 1.00 56.79  ? 536  TYR A CG  1 
ATOM   724  C  CD1 . TYR A 1 97  ? 31.348 3.175   73.119 1.00 58.79  ? 536  TYR A CD1 1 
ATOM   725  C  CD2 . TYR A 1 97  ? 32.944 4.941   73.084 1.00 57.65  ? 536  TYR A CD2 1 
ATOM   726  C  CE1 . TYR A 1 97  ? 32.227 2.389   73.845 1.00 63.66  ? 536  TYR A CE1 1 
ATOM   727  C  CE2 . TYR A 1 97  ? 33.830 4.161   73.809 1.00 57.68  ? 536  TYR A CE2 1 
ATOM   728  C  CZ  . TYR A 1 97  ? 33.466 2.887   74.186 1.00 62.70  ? 536  TYR A CZ  1 
ATOM   729  O  OH  . TYR A 1 97  ? 34.346 2.111   74.907 1.00 66.33  ? 536  TYR A OH  1 
ATOM   730  N  N   . PHE A 1 98  ? 27.730 5.397   73.238 1.00 56.76  ? 537  PHE A N   1 
ATOM   731  C  CA  . PHE A 1 98  ? 26.670 4.812   74.049 1.00 56.77  ? 537  PHE A CA  1 
ATOM   732  C  C   . PHE A 1 98  ? 25.651 4.185   73.110 1.00 58.84  ? 537  PHE A C   1 
ATOM   733  O  O   . PHE A 1 98  ? 25.679 4.405   71.896 1.00 58.84  ? 537  PHE A O   1 
ATOM   734  C  CB  . PHE A 1 98  ? 26.006 5.864   74.945 1.00 55.83  ? 537  PHE A CB  1 
ATOM   735  C  CG  . PHE A 1 98  ? 25.245 6.912   74.176 1.00 58.08  ? 537  PHE A CG  1 
ATOM   736  C  CD1 . PHE A 1 98  ? 25.887 8.045   73.702 1.00 57.33  ? 537  PHE A CD1 1 
ATOM   737  C  CD2 . PHE A 1 98  ? 23.892 6.755   73.909 1.00 58.30  ? 537  PHE A CD2 1 
ATOM   738  C  CE1 . PHE A 1 98  ? 25.191 9.006   72.981 1.00 57.55  ? 537  PHE A CE1 1 
ATOM   739  C  CE2 . PHE A 1 98  ? 23.194 7.709   73.187 1.00 59.20  ? 537  PHE A CE2 1 
ATOM   740  C  CZ  . PHE A 1 98  ? 23.844 8.838   72.726 1.00 57.07  ? 537  PHE A CZ  1 
ATOM   741  N  N   . THR A 1 99  ? 24.734 3.412   73.687 1.00 59.09  ? 538  THR A N   1 
ATOM   742  C  CA  . THR A 1 99  ? 23.643 2.804   72.935 1.00 62.46  ? 538  THR A CA  1 
ATOM   743  C  C   . THR A 1 99  ? 22.340 3.497   73.301 1.00 63.93  ? 538  THR A C   1 
ATOM   744  O  O   . THR A 1 99  ? 21.975 3.558   74.480 1.00 63.96  ? 538  THR A O   1 
ATOM   745  C  CB  . THR A 1 99  ? 23.538 1.304   73.206 1.00 60.69  ? 538  THR A CB  1 
ATOM   746  O  OG1 . THR A 1 99  ? 24.780 0.667   72.892 1.00 61.46  ? 538  THR A OG1 1 
ATOM   747  C  CG2 . THR A 1 99  ? 22.444 0.682   72.354 1.00 62.41  ? 538  THR A CG2 1 
ATOM   748  N  N   . HIS A 1 100 ? 21.636 3.999   72.291 1.00 66.47  ? 539  HIS A N   1 
ATOM   749  C  CA  . HIS A 1 100 ? 20.357 4.673   72.483 1.00 68.89  ? 539  HIS A CA  1 
ATOM   750  C  C   . HIS A 1 100 ? 19.241 3.721   72.077 1.00 72.89  ? 539  HIS A C   1 
ATOM   751  O  O   . HIS A 1 100 ? 19.122 3.357   70.903 1.00 72.84  ? 539  HIS A O   1 
ATOM   752  C  CB  . HIS A 1 100 ? 20.294 5.967   71.676 1.00 66.35  ? 539  HIS A CB  1 
ATOM   753  C  CG  . HIS A 1 100 ? 18.940 6.605   71.669 1.00 68.41  ? 539  HIS A CG  1 
ATOM   754  N  ND1 . HIS A 1 100 ? 18.479 7.389   72.706 1.00 66.60  ? 539  HIS A ND1 1 
ATOM   755  C  CD2 . HIS A 1 100 ? 17.942 6.568   70.753 1.00 68.76  ? 539  HIS A CD2 1 
ATOM   756  C  CE1 . HIS A 1 100 ? 17.258 7.809   72.427 1.00 68.31  ? 539  HIS A CE1 1 
ATOM   757  N  NE2 . HIS A 1 100 ? 16.909 7.325   71.248 1.00 69.28  ? 539  HIS A NE2 1 
ATOM   758  N  N   . VAL A 1 101 ? 18.429 3.315   73.049 1.00 76.29  ? 540  VAL A N   1 
ATOM   759  C  CA  . VAL A 1 101 ? 17.254 2.498   72.770 1.00 78.19  ? 540  VAL A CA  1 
ATOM   760  C  C   . VAL A 1 101 ? 16.180 3.421   72.204 1.00 79.75  ? 540  VAL A C   1 
ATOM   761  O  O   . VAL A 1 101 ? 15.691 4.315   72.900 1.00 79.87  ? 540  VAL A O   1 
ATOM   762  C  CB  . VAL A 1 101 ? 16.757 1.767   74.022 1.00 75.13  ? 540  VAL A CB  1 
ATOM   763  C  CG1 . VAL A 1 101 ? 15.889 0.582   73.626 1.00 77.16  ? 540  VAL A CG1 1 
ATOM   764  C  CG2 . VAL A 1 101 ? 17.927 1.314   74.880 1.00 70.18  ? 540  VAL A CG2 1 
ATOM   765  N  N   . SER A 1 102 ? 15.819 3.207   70.936 1.00 81.52  ? 541  SER A N   1 
ATOM   766  C  CA  . SER A 1 102 ? 14.862 4.070   70.254 1.00 82.90  ? 541  SER A CA  1 
ATOM   767  C  C   . SER A 1 102 ? 13.565 4.173   71.045 1.00 87.75  ? 541  SER A C   1 
ATOM   768  O  O   . SER A 1 102 ? 13.188 3.260   71.786 1.00 88.81  ? 541  SER A O   1 
ATOM   769  C  CB  . SER A 1 102 ? 14.574 3.533   68.844 1.00 85.16  ? 541  SER A CB  1 
ATOM   770  O  OG  . SER A 1 102 ? 13.941 4.505   68.030 1.00 89.03  ? 541  SER A OG  1 
ATOM   771  N  N   . GLN A 1 103 ? 12.886 5.314   70.898 1.00 92.34  ? 542  GLN A N   1 
ATOM   772  C  CA  . GLN A 1 103 ? 11.523 5.432   71.402 1.00 94.21  ? 542  GLN A CA  1 
ATOM   773  C  C   . GLN A 1 103 ? 10.601 4.397   70.775 1.00 93.84  ? 542  GLN A C   1 
ATOM   774  O  O   . GLN A 1 103 ? 9.533  4.111   71.329 1.00 96.00  ? 542  GLN A O   1 
ATOM   775  C  CB  . GLN A 1 103 ? 10.967 6.831   71.126 1.00 95.77  ? 542  GLN A CB  1 
ATOM   776  C  CG  . GLN A 1 103 ? 11.796 7.974   71.680 1.00 96.05  ? 542  GLN A CG  1 
ATOM   777  C  CD  . GLN A 1 103 ? 10.942 9.172   72.056 1.00 99.12  ? 542  GLN A CD  1 
ATOM   778  O  OE1 . GLN A 1 103 ? 10.944 9.616   73.205 1.00 100.31 ? 542  GLN A OE1 1 
ATOM   779  N  NE2 . GLN A 1 103 ? 10.200 9.699   71.086 1.00 95.90  ? 542  GLN A NE2 1 
ATOM   780  N  N   . GLN A 1 104 ? 10.990 3.834   69.632 1.00 91.01  ? 543  GLN A N   1 
ATOM   781  C  CA  . GLN A 1 104 ? 10.152 2.900   68.899 1.00 90.05  ? 543  GLN A CA  1 
ATOM   782  C  C   . GLN A 1 104 ? 10.502 1.443   69.165 1.00 91.44  ? 543  GLN A C   1 
ATOM   783  O  O   . GLN A 1 104 ? 9.652  0.573   68.948 1.00 93.58  ? 543  GLN A O   1 
ATOM   784  C  CB  . GLN A 1 104 ? 10.248 3.177   67.394 1.00 90.15  ? 543  GLN A CB  1 
ATOM   785  C  CG  . GLN A 1 104 ? 10.584 4.632   67.018 1.00 93.96  ? 543  GLN A CG  1 
ATOM   786  C  CD  . GLN A 1 104 ? 9.686  5.679   67.680 1.00 96.31  ? 543  GLN A CD  1 
ATOM   787  O  OE1 . GLN A 1 104 ? 8.581  5.383   68.139 1.00 96.02  ? 543  GLN A OE1 1 
ATOM   788  N  NE2 . GLN A 1 104 ? 10.171 6.917   67.728 1.00 92.18  ? 543  GLN A NE2 1 
ATOM   789  N  N   . GLY A 1 105 ? 11.721 1.155   69.618 1.00 90.88  ? 544  GLY A N   1 
ATOM   790  C  CA  . GLY A 1 105 ? 12.075 -0.201  69.990 1.00 88.81  ? 544  GLY A CA  1 
ATOM   791  C  C   . GLY A 1 105 ? 13.478 -0.621  69.607 1.00 88.74  ? 544  GLY A C   1 
ATOM   792  O  O   . GLY A 1 105 ? 14.117 -1.393  70.327 1.00 88.90  ? 544  GLY A O   1 
ATOM   793  N  N   . ASN A 1 106 ? 13.964 -0.125  68.472 1.00 87.79  ? 545  ASN A N   1 
ATOM   794  C  CA  . ASN A 1 106 ? 15.291 -0.490  68.002 1.00 86.49  ? 545  ASN A CA  1 
ATOM   795  C  C   . ASN A 1 106 ? 16.370 0.065   68.931 1.00 84.66  ? 545  ASN A C   1 
ATOM   796  O  O   . ASN A 1 106 ? 16.164 1.037   69.661 1.00 83.98  ? 545  ASN A O   1 
ATOM   797  C  CB  . ASN A 1 106 ? 15.514 0.024   66.582 1.00 85.86  ? 545  ASN A CB  1 
ATOM   798  C  CG  . ASN A 1 106 ? 14.257 -0.042  65.733 1.00 89.54  ? 545  ASN A CG  1 
ATOM   799  O  OD1 . ASN A 1 106 ? 13.884 -1.108  65.239 1.00 89.59  ? 545  ASN A OD1 1 
ATOM   800  N  ND2 . ASN A 1 106 ? 13.600 1.101   65.552 1.00 87.37  ? 545  ASN A ND2 1 
ATOM   801  N  N   . ALA A 1 107 ? 17.536 -0.574  68.894 1.00 82.88  ? 546  ALA A N   1 
ATOM   802  C  CA  . ALA A 1 107 ? 18.700 -0.142  69.657 1.00 78.63  ? 546  ALA A CA  1 
ATOM   803  C  C   . ALA A 1 107 ? 19.718 0.456   68.697 1.00 76.29  ? 546  ALA A C   1 
ATOM   804  O  O   . ALA A 1 107 ? 20.007 -0.130  67.648 1.00 77.00  ? 546  ALA A O   1 
ATOM   805  C  CB  . ALA A 1 107 ? 19.314 -1.306  70.437 1.00 73.63  ? 546  ALA A CB  1 
ATOM   806  N  N   . HIS A 1 108 ? 20.249 1.623   69.052 1.00 74.82  ? 547  HIS A N   1 
ATOM   807  C  CA  . HIS A 1 108 ? 21.157 2.371   68.191 1.00 70.22  ? 547  HIS A CA  1 
ATOM   808  C  C   . HIS A 1 108 ? 22.460 2.630   68.928 1.00 67.65  ? 547  HIS A C   1 
ATOM   809  O  O   . HIS A 1 108 ? 22.457 3.226   70.012 1.00 65.38  ? 547  HIS A O   1 
ATOM   810  C  CB  . HIS A 1 108 ? 20.541 3.701   67.756 1.00 68.00  ? 547  HIS A CB  1 
ATOM   811  C  CG  . HIS A 1 108 ? 19.353 3.555   66.862 1.00 71.82  ? 547  HIS A CG  1 
ATOM   812  N  ND1 . HIS A 1 108 ? 19.462 3.449   65.493 1.00 73.06  ? 547  HIS A ND1 1 
ATOM   813  C  CD2 . HIS A 1 108 ? 18.029 3.508   67.140 1.00 75.08  ? 547  HIS A CD2 1 
ATOM   814  C  CE1 . HIS A 1 108 ? 18.256 3.339   64.965 1.00 75.87  ? 547  HIS A CE1 1 
ATOM   815  N  NE2 . HIS A 1 108 ? 17.369 3.371   65.944 1.00 78.71  ? 547  HIS A NE2 1 
ATOM   816  N  N   . VAL A 1 109 ? 23.571 2.194   68.333 1.00 65.56  ? 548  VAL A N   1 
ATOM   817  C  CA  . VAL A 1 109 ? 24.874 2.687   68.755 1.00 64.11  ? 548  VAL A CA  1 
ATOM   818  C  C   . VAL A 1 109 ? 25.042 4.111   68.248 1.00 62.10  ? 548  VAL A C   1 
ATOM   819  O  O   . VAL A 1 109 ? 24.685 4.432   67.105 1.00 63.29  ? 548  VAL A O   1 
ATOM   820  C  CB  . VAL A 1 109 ? 25.998 1.770   68.243 1.00 64.30  ? 548  VAL A CB  1 
ATOM   821  C  CG1 . VAL A 1 109 ? 25.832 1.509   66.759 1.00 66.07  ? 548  VAL A CG1 1 
ATOM   822  C  CG2 . VAL A 1 109 ? 27.357 2.382   68.529 1.00 60.92  ? 548  VAL A CG2 1 
ATOM   823  N  N   . CYS A 1 110 ? 25.545 4.986   69.113 1.00 60.22  ? 549  CYS A N   1 
ATOM   824  C  CA  . CYS A 1 110 ? 25.799 6.371   68.754 1.00 59.10  ? 549  CYS A CA  1 
ATOM   825  C  C   . CYS A 1 110 ? 27.203 6.755   69.185 1.00 56.94  ? 549  CYS A C   1 
ATOM   826  O  O   . CYS A 1 110 ? 27.677 6.332   70.243 1.00 56.35  ? 549  CYS A O   1 
ATOM   827  C  CB  . CYS A 1 110 ? 24.775 7.340   69.389 1.00 60.09  ? 549  CYS A CB  1 
ATOM   828  S  SG  . CYS A 1 110 ? 23.045 6.786   69.421 1.00 61.59  ? 549  CYS A SG  1 
ATOM   829  N  N   . LEU A 1 111 ? 27.859 7.556   68.354 1.00 55.09  ? 550  LEU A N   1 
ATOM   830  C  CA  . LEU A 1 111 ? 29.194 8.057   68.631 1.00 53.79  ? 550  LEU A CA  1 
ATOM   831  C  C   . LEU A 1 111 ? 29.110 9.554   68.886 1.00 53.21  ? 550  LEU A C   1 
ATOM   832  O  O   . LEU A 1 111 ? 28.390 10.272  68.184 1.00 52.31  ? 550  LEU A O   1 
ATOM   833  C  CB  . LEU A 1 111 ? 30.146 7.765   67.464 1.00 55.14  ? 550  LEU A CB  1 
ATOM   834  C  CG  . LEU A 1 111 ? 30.687 6.346   67.237 1.00 56.07  ? 550  LEU A CG  1 
ATOM   835  C  CD1 . LEU A 1 111 ? 29.587 5.357   66.864 1.00 54.56  ? 550  LEU A CD1 1 
ATOM   836  C  CD2 . LEU A 1 111 ? 31.757 6.367   66.158 1.00 54.12  ? 550  LEU A CD2 1 
ATOM   837  N  N   . VAL A 1 112 ? 29.825 10.019  69.904 1.00 51.62  ? 551  VAL A N   1 
ATOM   838  C  CA  . VAL A 1 112 ? 29.877 11.436  70.240 1.00 48.84  ? 551  VAL A CA  1 
ATOM   839  C  C   . VAL A 1 112 ? 31.181 12.004  69.703 1.00 48.35  ? 551  VAL A C   1 
ATOM   840  O  O   . VAL A 1 112 ? 32.255 11.431  69.923 1.00 49.62  ? 551  VAL A O   1 
ATOM   841  C  CB  . VAL A 1 112 ? 29.753 11.658  71.756 1.00 48.76  ? 551  VAL A CB  1 
ATOM   842  C  CG1 . VAL A 1 112 ? 29.770 13.141  72.072 1.00 50.40  ? 551  VAL A CG1 1 
ATOM   843  C  CG2 . VAL A 1 112 ? 28.477 11.024  72.278 1.00 49.32  ? 551  VAL A CG2 1 
ATOM   844  N  N   . PHE A 1 113 ? 31.090 13.120  68.986 1.00 47.14  ? 552  PHE A N   1 
ATOM   845  C  CA  . PHE A 1 113 ? 32.251 13.751  68.379 1.00 49.38  ? 552  PHE A CA  1 
ATOM   846  C  C   . PHE A 1 113 ? 32.340 15.210  68.800 1.00 48.69  ? 552  PHE A C   1 
ATOM   847  O  O   . PHE A 1 113 ? 31.356 15.823  69.222 1.00 47.17  ? 552  PHE A O   1 
ATOM   848  C  CB  . PHE A 1 113 ? 32.203 13.688  66.846 1.00 48.42  ? 552  PHE A CB  1 
ATOM   849  C  CG  . PHE A 1 113 ? 32.157 12.300  66.293 1.00 48.19  ? 552  PHE A CG  1 
ATOM   850  C  CD1 . PHE A 1 113 ? 33.321 11.567  66.129 1.00 49.85  ? 552  PHE A CD1 1 
ATOM   851  C  CD2 . PHE A 1 113 ? 30.953 11.731  65.924 1.00 48.69  ? 552  PHE A CD2 1 
ATOM   852  C  CE1 . PHE A 1 113 ? 33.284 10.290  65.613 1.00 51.16  ? 552  PHE A CE1 1 
ATOM   853  C  CE2 . PHE A 1 113 ? 30.907 10.454  65.407 1.00 52.19  ? 552  PHE A CE2 1 
ATOM   854  C  CZ  . PHE A 1 113 ? 32.075 9.730   65.249 1.00 53.33  ? 552  PHE A CZ  1 
ATOM   855  N  N   . GLU A 1 114 ? 33.543 15.763  68.665 1.00 47.06  ? 553  GLU A N   1 
ATOM   856  C  CA  . GLU A 1 114 ? 33.707 17.206  68.704 1.00 47.38  ? 553  GLU A CA  1 
ATOM   857  C  C   . GLU A 1 114 ? 32.734 17.847  67.725 1.00 50.10  ? 553  GLU A C   1 
ATOM   858  O  O   . GLU A 1 114 ? 32.284 17.213  66.765 1.00 51.72  ? 553  GLU A O   1 
ATOM   859  C  CB  . GLU A 1 114 ? 35.150 17.575  68.353 1.00 46.07  ? 553  GLU A CB  1 
ATOM   860  C  CG  . GLU A 1 114 ? 35.726 16.721  67.235 1.00 47.10  ? 553  GLU A CG  1 
ATOM   861  C  CD  . GLU A 1 114 ? 37.132 17.121  66.837 1.00 49.70  ? 553  GLU A CD  1 
ATOM   862  O  OE1 . GLU A 1 114 ? 37.626 18.150  67.345 1.00 53.50  ? 553  GLU A OE1 1 
ATOM   863  O  OE2 . GLU A 1 114 ? 37.743 16.406  66.012 1.00 47.35  ? 553  GLU A OE2 1 
ATOM   864  N  N   . HIS A 1 115 ? 32.379 19.103  67.978 1.00 48.24  ? 554  HIS A N   1 
ATOM   865  C  CA  . HIS A 1 115 ? 31.429 19.773  67.104 1.00 47.92  ? 554  HIS A CA  1 
ATOM   866  C  C   . HIS A 1 115 ? 31.997 19.882  65.696 1.00 50.78  ? 554  HIS A C   1 
ATOM   867  O  O   . HIS A 1 115 ? 33.123 20.345  65.501 1.00 52.86  ? 554  HIS A O   1 
ATOM   868  C  CB  . HIS A 1 115 ? 31.076 21.154  67.642 1.00 49.79  ? 554  HIS A CB  1 
ATOM   869  C  CG  . HIS A 1 115 ? 29.976 21.822  66.881 1.00 53.39  ? 554  HIS A CG  1 
ATOM   870  N  ND1 . HIS A 1 115 ? 28.766 21.207  66.633 1.00 52.84  ? 554  HIS A ND1 1 
ATOM   871  C  CD2 . HIS A 1 115 ? 29.908 23.041  66.294 1.00 52.83  ? 554  HIS A CD2 1 
ATOM   872  C  CE1 . HIS A 1 115 ? 27.997 22.024  65.936 1.00 55.18  ? 554  HIS A CE1 1 
ATOM   873  N  NE2 . HIS A 1 115 ? 28.665 23.143  65.717 1.00 54.29  ? 554  HIS A NE2 1 
ATOM   874  N  N   . LEU A 1 116 ? 31.207 19.454  64.716 1.00 53.28  ? 555  LEU A N   1 
ATOM   875  C  CA  . LEU A 1 116 ? 31.656 19.309  63.338 1.00 52.42  ? 555  LEU A CA  1 
ATOM   876  C  C   . LEU A 1 116 ? 31.188 20.480  62.485 1.00 55.43  ? 555  LEU A C   1 
ATOM   877  O  O   . LEU A 1 116 ? 30.060 20.959  62.633 1.00 59.13  ? 555  LEU A O   1 
ATOM   878  C  CB  . LEU A 1 116 ? 31.133 18.002  62.739 1.00 49.99  ? 555  LEU A CB  1 
ATOM   879  C  CG  . LEU A 1 116 ? 31.385 16.730  63.549 1.00 46.19  ? 555  LEU A CG  1 
ATOM   880  C  CD1 . LEU A 1 116 ? 30.742 15.528  62.874 1.00 44.84  ? 555  LEU A CD1 1 
ATOM   881  C  CD2 . LEU A 1 116 ? 32.875 16.511  63.745 1.00 45.58  ? 555  LEU A CD2 1 
ATOM   882  N  N   . GLY A 1 117 ? 32.060 20.929  61.586 1.00 54.37  ? 556  GLY A N   1 
ATOM   883  C  CA  . GLY A 1 117 ? 31.692 21.907  60.592 1.00 54.76  ? 556  GLY A CA  1 
ATOM   884  C  C   . GLY A 1 117 ? 31.343 21.239  59.277 1.00 53.90  ? 556  GLY A C   1 
ATOM   885  O  O   . GLY A 1 117 ? 31.265 20.010  59.180 1.00 49.95  ? 556  GLY A O   1 
ATOM   886  N  N   . PRO A 1 118 ? 31.128 22.037  58.236 1.00 53.76  ? 557  PRO A N   1 
ATOM   887  C  CA  . PRO A 1 118 ? 30.726 21.472  56.945 1.00 52.62  ? 557  PRO A CA  1 
ATOM   888  C  C   . PRO A 1 118 ? 31.845 20.658  56.314 1.00 53.37  ? 557  PRO A C   1 
ATOM   889  O  O   . PRO A 1 118 ? 33.012 20.728  56.709 1.00 52.96  ? 557  PRO A O   1 
ATOM   890  C  CB  . PRO A 1 118 ? 30.401 22.708  56.104 1.00 56.74  ? 557  PRO A CB  1 
ATOM   891  C  CG  . PRO A 1 118 ? 31.232 23.791  56.705 1.00 58.09  ? 557  PRO A CG  1 
ATOM   892  C  CD  . PRO A 1 118 ? 31.270 23.501  58.181 1.00 58.74  ? 557  PRO A CD  1 
ATOM   893  N  N   . SER A 1 119 ? 31.463 19.870  55.313 1.00 51.22  ? 558  SER A N   1 
ATOM   894  C  CA  . SER A 1 119 ? 32.398 18.979  54.650 1.00 51.36  ? 558  SER A CA  1 
ATOM   895  C  C   . SER A 1 119 ? 33.142 19.708  53.535 1.00 50.85  ? 558  SER A C   1 
ATOM   896  O  O   . SER A 1 119 ? 32.796 20.824  53.140 1.00 52.65  ? 558  SER A O   1 
ATOM   897  C  CB  . SER A 1 119 ? 31.666 17.760  54.093 1.00 50.36  ? 558  SER A CB  1 
ATOM   898  O  OG  . SER A 1 119 ? 31.187 18.014  52.788 1.00 52.70  ? 558  SER A OG  1 
ATOM   899  N  N   . LEU A 1 120 ? 34.195 19.059  53.030 1.00 49.92  ? 559  LEU A N   1 
ATOM   900  C  CA  . LEU A 1 120 ? 34.897 19.606  51.875 1.00 50.46  ? 559  LEU A CA  1 
ATOM   901  C  C   . LEU A 1 120 ? 34.015 19.568  50.638 1.00 50.23  ? 559  LEU A C   1 
ATOM   902  O  O   . LEU A 1 120 ? 34.078 20.476  49.802 1.00 50.24  ? 559  LEU A O   1 
ATOM   903  C  CB  . LEU A 1 120 ? 36.203 18.845  51.637 1.00 46.14  ? 559  LEU A CB  1 
ATOM   904  C  CG  . LEU A 1 120 ? 37.099 19.370  50.511 1.00 47.15  ? 559  LEU A CG  1 
ATOM   905  C  CD1 . LEU A 1 120 ? 37.353 20.865  50.661 1.00 44.87  ? 559  LEU A CD1 1 
ATOM   906  C  CD2 . LEU A 1 120 ? 38.413 18.606  50.460 1.00 44.46  ? 559  LEU A CD2 1 
ATOM   907  N  N   . PHE A 1 121 ? 33.179 18.537  50.512 1.00 50.64  ? 560  PHE A N   1 
ATOM   908  C  CA  . PHE A 1 121 ? 32.188 18.525  49.444 1.00 52.25  ? 560  PHE A CA  1 
ATOM   909  C  C   . PHE A 1 121 ? 31.215 19.686  49.595 1.00 55.05  ? 560  PHE A C   1 
ATOM   910  O  O   . PHE A 1 121 ? 30.866 20.347  48.609 1.00 54.49  ? 560  PHE A O   1 
ATOM   911  C  CB  . PHE A 1 121 ? 31.448 17.190  49.442 1.00 53.53  ? 560  PHE A CB  1 
ATOM   912  C  CG  . PHE A 1 121 ? 30.137 17.224  48.714 1.00 57.83  ? 560  PHE A CG  1 
ATOM   913  C  CD1 . PHE A 1 121 ? 30.093 17.117  47.333 1.00 56.62  ? 560  PHE A CD1 1 
ATOM   914  C  CD2 . PHE A 1 121 ? 28.945 17.354  49.411 1.00 59.80  ? 560  PHE A CD2 1 
ATOM   915  C  CE1 . PHE A 1 121 ? 28.885 17.145  46.661 1.00 58.63  ? 560  PHE A CE1 1 
ATOM   916  C  CE2 . PHE A 1 121 ? 27.734 17.382  48.745 1.00 61.25  ? 560  PHE A CE2 1 
ATOM   917  C  CZ  . PHE A 1 121 ? 27.704 17.277  47.367 1.00 59.98  ? 560  PHE A CZ  1 
ATOM   918  N  N   . ASP A 1 122 ? 30.772 19.952  50.829 1.00 57.04  ? 561  ASP A N   1 
ATOM   919  C  CA  . ASP A 1 122 ? 29.905 21.100  51.081 1.00 55.33  ? 561  ASP A CA  1 
ATOM   920  C  C   . ASP A 1 122 ? 30.582 22.397  50.669 1.00 55.21  ? 561  ASP A C   1 
ATOM   921  O  O   . ASP A 1 122 ? 29.951 23.275  50.070 1.00 57.90  ? 561  ASP A O   1 
ATOM   922  C  CB  . ASP A 1 122 ? 29.517 21.153  52.558 1.00 54.80  ? 561  ASP A CB  1 
ATOM   923  C  CG  . ASP A 1 122 ? 28.682 19.966  52.983 1.00 56.71  ? 561  ASP A CG  1 
ATOM   924  O  OD1 . ASP A 1 122 ? 27.924 19.438  52.140 1.00 58.31  ? 561  ASP A OD1 1 
ATOM   925  O  OD2 . ASP A 1 122 ? 28.786 19.554  54.157 1.00 57.09  ? 561  ASP A OD2 1 
ATOM   926  N  N   . VAL A 1 123 ? 31.869 22.535  50.988 1.00 53.91  ? 562  VAL A N   1 
ATOM   927  C  CA  . VAL A 1 123 ? 32.610 23.727  50.596 1.00 54.55  ? 562  VAL A CA  1 
ATOM   928  C  C   . VAL A 1 123 ? 32.631 23.863  49.081 1.00 55.56  ? 562  VAL A C   1 
ATOM   929  O  O   . VAL A 1 123 ? 32.447 24.959  48.537 1.00 58.78  ? 562  VAL A O   1 
ATOM   930  C  CB  . VAL A 1 123 ? 34.031 23.684  51.188 1.00 54.75  ? 562  VAL A CB  1 
ATOM   931  C  CG1 . VAL A 1 123 ? 34.996 24.504  50.338 1.00 53.36  ? 562  VAL A CG1 1 
ATOM   932  C  CG2 . VAL A 1 123 ? 34.014 24.174  52.630 1.00 54.68  ? 562  VAL A CG2 1 
ATOM   933  N  N   . LEU A 1 124 ? 32.833 22.751  48.373 1.00 53.55  ? 563  LEU A N   1 
ATOM   934  C  CA  . LEU A 1 124 ? 32.879 22.810  46.917 1.00 53.87  ? 563  LEU A CA  1 
ATOM   935  C  C   . LEU A 1 124 ? 31.509 23.125  46.330 1.00 55.88  ? 563  LEU A C   1 
ATOM   936  O  O   . LEU A 1 124 ? 31.394 23.972  45.437 1.00 55.36  ? 563  LEU A O   1 
ATOM   937  C  CB  . LEU A 1 124 ? 33.420 21.496  46.353 1.00 53.60  ? 563  LEU A CB  1 
ATOM   938  C  CG  . LEU A 1 124 ? 34.908 21.215  46.590 1.00 53.05  ? 563  LEU A CG  1 
ATOM   939  C  CD1 . LEU A 1 124 ? 35.344 19.976  45.837 1.00 51.02  ? 563  LEU A CD1 1 
ATOM   940  C  CD2 . LEU A 1 124 ? 35.769 22.401  46.195 1.00 53.19  ? 563  LEU A CD2 1 
ATOM   941  N  N   . MET A 1 125 ? 30.458 22.459  46.818 1.00 54.85  ? 564  MET A N   1 
ATOM   942  C  CA  . MET A 1 125 ? 29.133 22.654  46.236 1.00 55.29  ? 564  MET A CA  1 
ATOM   943  C  C   . MET A 1 125 ? 28.660 24.093  46.402 1.00 57.39  ? 564  MET A C   1 
ATOM   944  O  O   . MET A 1 125 ? 28.130 24.693  45.459 1.00 56.23  ? 564  MET A O   1 
ATOM   945  C  CB  . MET A 1 125 ? 28.128 21.685  46.860 1.00 55.16  ? 564  MET A CB  1 
ATOM   946  C  CG  . MET A 1 125 ? 26.771 21.662  46.156 1.00 53.63  ? 564  MET A CG  1 
ATOM   947  S  SD  . MET A 1 125 ? 25.556 20.552  46.912 1.00 61.24  ? 564  MET A SD  1 
ATOM   948  C  CE  . MET A 1 125 ? 24.787 21.621  48.128 1.00 54.99  ? 564  MET A CE  1 
ATOM   949  N  N   . ARG A 1 126 ? 28.854 24.668  47.591 1.00 58.28  ? 565  ARG A N   1 
ATOM   950  C  CA  . ARG A 1 126 ? 28.362 26.018  47.842 1.00 59.35  ? 565  ARG A CA  1 
ATOM   951  C  C   . ARG A 1 126 ? 29.044 27.047  46.950 1.00 58.09  ? 565  ARG A C   1 
ATOM   952  O  O   . ARG A 1 126 ? 28.434 28.066  46.612 1.00 62.81  ? 565  ARG A O   1 
ATOM   953  C  CB  . ARG A 1 126 ? 28.536 26.372  49.319 1.00 63.30  ? 565  ARG A CB  1 
ATOM   954  C  CG  . ARG A 1 126 ? 27.670 25.526  50.244 1.00 63.49  ? 565  ARG A CG  1 
ATOM   955  C  CD  . ARG A 1 126 ? 28.188 25.522  51.674 1.00 64.63  ? 565  ARG A CD  1 
ATOM   956  N  NE  . ARG A 1 126 ? 27.346 24.702  52.543 1.00 70.55  ? 565  ARG A NE  1 
ATOM   957  C  CZ  . ARG A 1 126 ? 27.463 24.638  53.866 1.00 67.16  ? 565  ARG A CZ  1 
ATOM   958  N  NH1 . ARG A 1 126 ? 28.392 25.352  54.491 1.00 69.91  ? 565  ARG A NH1 1 
ATOM   959  N  NH2 . ARG A 1 126 ? 26.647 23.862  54.567 1.00 63.34  ? 565  ARG A NH2 1 
ATOM   960  N  N   . ASN A 1 127 ? 30.294 26.804  46.548 1.00 57.15  ? 566  ASN A N   1 
ATOM   961  C  CA  . ASN A 1 127 ? 30.971 27.653  45.573 1.00 58.39  ? 566  ASN A CA  1 
ATOM   962  C  C   . ASN A 1 127 ? 30.699 27.218  44.137 1.00 60.44  ? 566  ASN A C   1 
ATOM   963  O  O   . ASN A 1 127 ? 31.544 27.429  43.254 1.00 60.33  ? 566  ASN A O   1 
ATOM   964  C  CB  . ASN A 1 127 ? 32.475 27.682  45.850 1.00 59.50  ? 566  ASN A CB  1 
ATOM   965  C  CG  . ASN A 1 127 ? 33.164 28.890  45.230 1.00 66.69  ? 566  ASN A CG  1 
ATOM   966  O  OD1 . ASN A 1 127 ? 32.512 29.785  44.686 1.00 66.84  ? 566  ASN A OD1 1 
ATOM   967  N  ND2 . ASN A 1 127 ? 34.491 28.916  45.304 1.00 68.15  ? 566  ASN A ND2 1 
ATOM   968  N  N   . HIS A 1 128 ? 29.540 26.601  43.888 1.00 59.48  ? 567  HIS A N   1 
ATOM   969  C  CA  . HIS A 1 128 ? 29.118 26.179  42.552 1.00 57.62  ? 567  HIS A CA  1 
ATOM   970  C  C   . HIS A 1 128 ? 30.148 25.268  41.888 1.00 59.59  ? 567  HIS A C   1 
ATOM   971  O  O   . HIS A 1 128 ? 30.279 25.247  40.660 1.00 60.70  ? 567  HIS A O   1 
ATOM   972  C  CB  . HIS A 1 128 ? 28.806 27.389  41.666 1.00 58.87  ? 567  HIS A CB  1 
ATOM   973  C  CG  . HIS A 1 128 ? 27.608 28.170  42.115 1.00 57.31  ? 567  HIS A CG  1 
ATOM   974  N  ND1 . HIS A 1 128 ? 26.485 28.326  41.332 1.00 57.15  ? 567  HIS A ND1 1 
ATOM   975  C  CD2 . HIS A 1 128 ? 27.357 28.834  43.269 1.00 55.67  ? 567  HIS A CD2 1 
ATOM   976  C  CE1 . HIS A 1 128 ? 25.594 29.054  41.982 1.00 54.70  ? 567  HIS A CE1 1 
ATOM   977  N  NE2 . HIS A 1 128 ? 26.099 29.377  43.160 1.00 53.07  ? 567  HIS A NE2 1 
ATOM   978  N  N   . PHE A 1 129 ? 30.875 24.500  42.701 1.00 58.12  ? 568  PHE A N   1 
ATOM   979  C  CA  . PHE A 1 129 ? 31.930 23.608  42.222 1.00 58.32  ? 568  PHE A CA  1 
ATOM   980  C  C   . PHE A 1 129 ? 32.995 24.369  41.435 1.00 58.09  ? 568  PHE A C   1 
ATOM   981  O  O   . PHE A 1 129 ? 33.578 23.846  40.484 1.00 58.22  ? 568  PHE A O   1 
ATOM   982  C  CB  . PHE A 1 129 ? 31.348 22.455  41.401 1.00 57.31  ? 568  PHE A CB  1 
ATOM   983  C  CG  . PHE A 1 129 ? 30.462 21.540  42.201 1.00 58.29  ? 568  PHE A CG  1 
ATOM   984  C  CD1 . PHE A 1 129 ? 30.929 20.955  43.367 1.00 57.07  ? 568  PHE A CD1 1 
ATOM   985  C  CD2 . PHE A 1 129 ? 29.160 21.282  41.803 1.00 57.07  ? 568  PHE A CD2 1 
ATOM   986  C  CE1 . PHE A 1 129 ? 30.121 20.120  44.115 1.00 55.38  ? 568  PHE A CE1 1 
ATOM   987  C  CE2 . PHE A 1 129 ? 28.346 20.449  42.546 1.00 55.32  ? 568  PHE A CE2 1 
ATOM   988  C  CZ  . PHE A 1 129 ? 28.828 19.869  43.706 1.00 56.57  ? 568  PHE A CZ  1 
ATOM   989  N  N   . ARG A 1 130 ? 33.251 25.612  41.834 1.00 59.08  ? 569  ARG A N   1 
ATOM   990  C  CA  . ARG A 1 130 ? 34.374 26.352  41.289 1.00 61.24  ? 569  ARG A CA  1 
ATOM   991  C  C   . ARG A 1 130 ? 35.686 25.753  41.794 1.00 59.52  ? 569  ARG A C   1 
ATOM   992  O  O   . ARG A 1 130 ? 35.730 25.159  42.875 1.00 58.60  ? 569  ARG A O   1 
ATOM   993  C  CB  . ARG A 1 130 ? 34.290 27.825  41.683 1.00 61.66  ? 569  ARG A CB  1 
ATOM   994  C  CG  . ARG A 1 130 ? 33.724 28.725  40.598 1.00 64.30  ? 569  ARG A CG  1 
ATOM   995  C  CD  . ARG A 1 130 ? 32.980 29.911  41.189 1.00 64.08  ? 569  ARG A CD  1 
ATOM   996  N  NE  . ARG A 1 130 ? 31.861 30.316  40.341 1.00 69.84  ? 569  ARG A NE  1 
ATOM   997  C  CZ  . ARG A 1 130 ? 30.674 30.703  40.800 1.00 68.56  ? 569  ARG A CZ  1 
ATOM   998  N  NH1 . ARG A 1 130 ? 30.449 30.742  42.108 1.00 66.21  ? 569  ARG A NH1 1 
ATOM   999  N  NH2 . ARG A 1 130 ? 29.712 31.051  39.953 1.00 65.81  ? 569  ARG A NH2 1 
ATOM   1000 N  N   . PRO A 1 131 ? 36.764 25.882  41.021 1.00 59.85  ? 570  PRO A N   1 
ATOM   1001 C  CA  . PRO A 1 131 ? 38.064 25.378  41.481 1.00 56.74  ? 570  PRO A CA  1 
ATOM   1002 C  C   . PRO A 1 131 ? 38.471 25.995  42.810 1.00 54.57  ? 570  PRO A C   1 
ATOM   1003 O  O   . PRO A 1 131 ? 38.210 27.168  43.079 1.00 59.32  ? 570  PRO A O   1 
ATOM   1004 C  CB  . PRO A 1 131 ? 39.023 25.786  40.354 1.00 56.40  ? 570  PRO A CB  1 
ATOM   1005 C  CG  . PRO A 1 131 ? 38.257 26.736  39.482 1.00 57.97  ? 570  PRO A CG  1 
ATOM   1006 C  CD  . PRO A 1 131 ? 36.824 26.361  39.631 1.00 59.05  ? 570  PRO A CD  1 
ATOM   1007 N  N   . LEU A 1 132 ? 39.102 25.191  43.640 1.00 54.11  ? 571  LEU A N   1 
ATOM   1008 C  CA  . LEU A 1 132 ? 39.606 25.640  44.934 1.00 55.08  ? 571  LEU A CA  1 
ATOM   1009 C  C   . LEU A 1 132 ? 40.993 26.248  44.762 1.00 53.21  ? 571  LEU A C   1 
ATOM   1010 O  O   . LEU A 1 132 ? 41.848 25.637  44.114 1.00 55.08  ? 571  LEU A O   1 
ATOM   1011 C  CB  . LEU A 1 132 ? 39.667 24.477  45.914 1.00 54.22  ? 571  LEU A CB  1 
ATOM   1012 C  CG  . LEU A 1 132 ? 39.897 24.775  47.393 1.00 54.34  ? 571  LEU A CG  1 
ATOM   1013 C  CD1 . LEU A 1 132 ? 38.662 25.404  48.010 1.00 54.81  ? 571  LEU A CD1 1 
ATOM   1014 C  CD2 . LEU A 1 132 ? 40.276 23.491  48.116 1.00 51.54  ? 571  LEU A CD2 1 
ATOM   1015 N  N   . PRO A 1 133 ? 41.253 27.432  45.316 1.00 55.68  ? 572  PRO A N   1 
ATOM   1016 C  CA  . PRO A 1 133 ? 42.558 28.073  45.104 1.00 54.70  ? 572  PRO A CA  1 
ATOM   1017 C  C   . PRO A 1 133 ? 43.704 27.206  45.607 1.00 54.22  ? 572  PRO A C   1 
ATOM   1018 O  O   . PRO A 1 133 ? 43.603 26.553  46.648 1.00 55.27  ? 572  PRO A O   1 
ATOM   1019 C  CB  . PRO A 1 133 ? 42.444 29.378  45.899 1.00 52.00  ? 572  PRO A CB  1 
ATOM   1020 C  CG  . PRO A 1 133 ? 40.976 29.639  45.983 1.00 53.10  ? 572  PRO A CG  1 
ATOM   1021 C  CD  . PRO A 1 133 ? 40.336 28.289  46.088 1.00 54.78  ? 572  PRO A CD  1 
ATOM   1022 N  N   . VAL A 1 134 ? 44.803 27.213  44.846 1.00 52.94  ? 573  VAL A N   1 
ATOM   1023 C  CA  . VAL A 1 134 ? 45.932 26.338  45.164 1.00 52.28  ? 573  VAL A CA  1 
ATOM   1024 C  C   . VAL A 1 134 ? 46.473 26.560  46.572 1.00 55.71  ? 573  VAL A C   1 
ATOM   1025 O  O   . VAL A 1 134 ? 46.730 25.565  47.272 1.00 55.55  ? 573  VAL A O   1 
ATOM   1026 C  CB  . VAL A 1 134 ? 47.021 26.473  44.079 1.00 51.87  ? 573  VAL A CB  1 
ATOM   1027 C  CG1 . VAL A 1 134 ? 48.303 25.779  44.516 1.00 50.92  ? 573  VAL A CG1 1 
ATOM   1028 C  CG2 . VAL A 1 134 ? 46.521 25.894  42.761 1.00 50.22  ? 573  VAL A CG2 1 
ATOM   1029 N  N   . PRO A 1 135 ? 46.670 27.798  47.056 1.00 58.70  ? 574  PRO A N   1 
ATOM   1030 C  CA  . PRO A 1 135 ? 47.139 27.946  48.448 1.00 55.58  ? 574  PRO A CA  1 
ATOM   1031 C  C   . PRO A 1 135 ? 46.234 27.267  49.463 1.00 54.44  ? 574  PRO A C   1 
ATOM   1032 O  O   . PRO A 1 135 ? 46.729 26.698  50.445 1.00 52.14  ? 574  PRO A O   1 
ATOM   1033 C  CB  . PRO A 1 135 ? 47.180 29.468  48.640 1.00 56.61  ? 574  PRO A CB  1 
ATOM   1034 C  CG  . PRO A 1 135 ? 47.393 30.005  47.271 1.00 53.46  ? 574  PRO A CG  1 
ATOM   1035 C  CD  . PRO A 1 135 ? 46.599 29.105  46.373 1.00 53.28  ? 574  PRO A CD  1 
ATOM   1036 N  N   . ILE A 1 136 ? 44.917 27.300  49.249 1.00 54.65  ? 575  ILE A N   1 
ATOM   1037 C  CA  . ILE A 1 136 ? 44.002 26.593  50.142 1.00 55.00  ? 575  ILE A CA  1 
ATOM   1038 C  C   . ILE A 1 136 ? 44.052 25.090  49.879 1.00 54.03  ? 575  ILE A C   1 
ATOM   1039 O  O   . ILE A 1 136 ? 44.019 24.284  50.817 1.00 51.38  ? 575  ILE A O   1 
ATOM   1040 C  CB  . ILE A 1 136 ? 42.574 27.150  49.996 1.00 54.57  ? 575  ILE A CB  1 
ATOM   1041 C  CG1 . ILE A 1 136 ? 42.592 28.681  49.979 1.00 55.68  ? 575  ILE A CG1 1 
ATOM   1042 C  CG2 . ILE A 1 136 ? 41.673 26.623  51.111 1.00 52.52  ? 575  ILE A CG2 1 
ATOM   1043 C  CD1 . ILE A 1 136 ? 41.225 29.311  49.779 1.00 56.11  ? 575  ILE A CD1 1 
ATOM   1044 N  N   . LEU A 1 137 ? 44.133 24.694  48.604 1.00 53.44  ? 576  LEU A N   1 
ATOM   1045 C  CA  . LEU A 1 137 ? 44.299 23.285  48.263 1.00 51.07  ? 576  LEU A CA  1 
ATOM   1046 C  C   . LEU A 1 137 ? 45.543 22.702  48.922 1.00 50.62  ? 576  LEU A C   1 
ATOM   1047 O  O   . LEU A 1 137 ? 45.538 21.547  49.360 1.00 49.10  ? 576  LEU A O   1 
ATOM   1048 C  CB  . LEU A 1 137 ? 44.369 23.119  46.742 1.00 52.68  ? 576  LEU A CB  1 
ATOM   1049 C  CG  . LEU A 1 137 ? 44.380 21.696  46.158 1.00 51.38  ? 576  LEU A CG  1 
ATOM   1050 C  CD1 . LEU A 1 137 ? 43.686 21.665  44.806 1.00 49.68  ? 576  LEU A CD1 1 
ATOM   1051 C  CD2 . LEU A 1 137 ? 45.790 21.146  46.021 1.00 48.64  ? 576  LEU A CD2 1 
ATOM   1052 N  N   . ARG A 1 138 ? 46.621 23.485  48.993 1.00 52.41  ? 577  ARG A N   1 
ATOM   1053 C  CA  . ARG A 1 138 ? 47.842 23.000  49.629 1.00 50.10  ? 577  ARG A CA  1 
ATOM   1054 C  C   . ARG A 1 138 ? 47.627 22.741  51.114 1.00 48.33  ? 577  ARG A C   1 
ATOM   1055 O  O   . ARG A 1 138 ? 48.057 21.707  51.638 1.00 46.58  ? 577  ARG A O   1 
ATOM   1056 C  CB  . ARG A 1 138 ? 48.977 24.001  49.416 1.00 50.03  ? 577  ARG A CB  1 
ATOM   1057 C  CG  . ARG A 1 138 ? 50.296 23.590  50.047 1.00 50.23  ? 577  ARG A CG  1 
ATOM   1058 C  CD  . ARG A 1 138 ? 51.298 24.737  50.051 1.00 49.84  ? 577  ARG A CD  1 
ATOM   1059 N  NE  . ARG A 1 138 ? 51.949 24.888  48.753 1.00 52.78  ? 577  ARG A NE  1 
ATOM   1060 C  CZ  . ARG A 1 138 ? 51.726 25.902  47.924 1.00 55.62  ? 577  ARG A CZ  1 
ATOM   1061 N  NH1 . ARG A 1 138 ? 50.871 26.859  48.261 1.00 56.98  ? 577  ARG A NH1 1 
ATOM   1062 N  NH2 . ARG A 1 138 ? 52.357 25.963  46.759 1.00 55.39  ? 577  ARG A NH2 1 
ATOM   1063 N  N   . ALA A 1 139 ? 46.958 23.665  51.806 1.00 49.79  ? 578  ALA A N   1 
ATOM   1064 C  CA  . ALA A 1 139 ? 46.741 23.498  53.239 1.00 47.72  ? 578  ALA A CA  1 
ATOM   1065 C  C   . ALA A 1 139 ? 45.902 22.262  53.526 1.00 47.42  ? 578  ALA A C   1 
ATOM   1066 O  O   . ALA A 1 139 ? 46.214 21.488  54.437 1.00 48.66  ? 578  ALA A O   1 
ATOM   1067 C  CB  . ALA A 1 139 ? 46.078 24.745  53.819 1.00 48.24  ? 578  ALA A CB  1 
ATOM   1068 N  N   . VAL A 1 140 ? 44.840 22.054  52.747 1.00 45.09  ? 579  VAL A N   1 
ATOM   1069 C  CA  . VAL A 1 140 ? 43.985 20.887  52.936 1.00 45.54  ? 579  VAL A CA  1 
ATOM   1070 C  C   . VAL A 1 140 ? 44.754 19.601  52.653 1.00 48.39  ? 579  VAL A C   1 
ATOM   1071 O  O   . VAL A 1 140 ? 44.655 18.621  53.404 1.00 45.52  ? 579  VAL A O   1 
ATOM   1072 C  CB  . VAL A 1 140 ? 42.735 21.004  52.048 1.00 44.47  ? 579  VAL A CB  1 
ATOM   1073 C  CG1 . VAL A 1 140 ? 41.960 19.700  52.065 1.00 46.09  ? 579  VAL A CG1 1 
ATOM   1074 C  CG2 . VAL A 1 140 ? 41.870 22.160  52.505 1.00 44.82  ? 579  VAL A CG2 1 
ATOM   1075 N  N   . ALA A 1 141 ? 45.534 19.585  51.568 1.00 49.31  ? 580  ALA A N   1 
ATOM   1076 C  CA  . ALA A 1 141 ? 46.285 18.390  51.200 1.00 44.56  ? 580  ALA A CA  1 
ATOM   1077 C  C   . ALA A 1 141 ? 47.330 18.037  52.250 1.00 46.20  ? 580  ALA A C   1 
ATOM   1078 O  O   . ALA A 1 141 ? 47.570 16.855  52.520 1.00 49.68  ? 580  ALA A O   1 
ATOM   1079 C  CB  . ALA A 1 141 ? 46.950 18.587  49.840 1.00 45.34  ? 580  ALA A CB  1 
ATOM   1080 N  N   . ARG A 1 142 ? 47.970 19.042  52.848 1.00 45.13  ? 581  ARG A N   1 
ATOM   1081 C  CA  . ARG A 1 142 ? 49.010 18.756  53.829 1.00 47.10  ? 581  ARG A CA  1 
ATOM   1082 C  C   . ARG A 1 142 ? 48.421 18.150  55.096 1.00 47.21  ? 581  ARG A C   1 
ATOM   1083 O  O   . ARG A 1 142 ? 48.927 17.144  55.608 1.00 51.64  ? 581  ARG A O   1 
ATOM   1084 C  CB  . ARG A 1 142 ? 49.793 20.024  54.152 1.00 48.59  ? 581  ARG A CB  1 
ATOM   1085 C  CG  . ARG A 1 142 ? 51.115 19.750  54.828 1.00 50.09  ? 581  ARG A CG  1 
ATOM   1086 C  CD  . ARG A 1 142 ? 51.513 20.887  55.734 1.00 49.59  ? 581  ARG A CD  1 
ATOM   1087 N  NE  . ARG A 1 142 ? 50.368 21.423  56.460 1.00 54.37  ? 581  ARG A NE  1 
ATOM   1088 C  CZ  . ARG A 1 142 ? 50.158 21.240  57.761 1.00 57.10  ? 581  ARG A CZ  1 
ATOM   1089 N  NH1 . ARG A 1 142 ? 51.013 20.527  58.486 1.00 55.04  ? 581  ARG A NH1 1 
ATOM   1090 N  NH2 . ARG A 1 142 ? 49.090 21.774  58.340 1.00 57.01  ? 581  ARG A NH2 1 
ATOM   1091 N  N   . GLN A 1 143 ? 47.350 18.745  55.619 1.00 45.60  ? 582  GLN A N   1 
ATOM   1092 C  CA  . GLN A 1 143 ? 46.720 18.194  56.812 1.00 44.51  ? 582  GLN A CA  1 
ATOM   1093 C  C   . GLN A 1 143 ? 46.118 16.827  56.532 1.00 46.60  ? 582  GLN A C   1 
ATOM   1094 O  O   . GLN A 1 143 ? 46.169 15.935  57.386 1.00 46.99  ? 582  GLN A O   1 
ATOM   1095 C  CB  . GLN A 1 143 ? 45.649 19.145  57.331 1.00 46.06  ? 582  GLN A CB  1 
ATOM   1096 C  CG  . GLN A 1 143 ? 46.185 20.491  57.745 1.00 48.74  ? 582  GLN A CG  1 
ATOM   1097 C  CD  . GLN A 1 143 ? 45.098 21.522  57.870 1.00 49.03  ? 582  GLN A CD  1 
ATOM   1098 O  OE1 . GLN A 1 143 ? 43.985 21.217  58.294 1.00 52.02  ? 582  GLN A OE1 1 
ATOM   1099 N  NE2 . GLN A 1 143 ? 45.410 22.753  57.500 1.00 52.74  ? 582  GLN A NE2 1 
ATOM   1100 N  N   . LEU A 1 144 ? 45.541 16.645  55.342 1.00 45.10  ? 583  LEU A N   1 
ATOM   1101 C  CA  . LEU A 1 144 ? 44.993 15.343  54.986 1.00 44.40  ? 583  LEU A CA  1 
ATOM   1102 C  C   . LEU A 1 144 ? 46.094 14.298  54.898 1.00 45.36  ? 583  LEU A C   1 
ATOM   1103 O  O   . LEU A 1 144 ? 45.937 13.177  55.396 1.00 44.78  ? 583  LEU A O   1 
ATOM   1104 C  CB  . LEU A 1 144 ? 44.227 15.435  53.668 1.00 44.40  ? 583  LEU A CB  1 
ATOM   1105 C  CG  . LEU A 1 144 ? 43.374 14.221  53.293 1.00 46.60  ? 583  LEU A CG  1 
ATOM   1106 C  CD1 . LEU A 1 144 ? 42.314 13.931  54.356 1.00 46.24  ? 583  LEU A CD1 1 
ATOM   1107 C  CD2 . LEU A 1 144 ? 42.731 14.427  51.927 1.00 48.67  ? 583  LEU A CD2 1 
ATOM   1108 N  N   . LEU A 1 145 ? 47.222 14.651  54.274 1.00 46.67  ? 584  LEU A N   1 
ATOM   1109 C  CA  . LEU A 1 145 ? 48.352 13.733  54.199 1.00 44.87  ? 584  LEU A CA  1 
ATOM   1110 C  C   . LEU A 1 145 ? 48.943 13.458  55.574 1.00 45.39  ? 584  LEU A C   1 
ATOM   1111 O  O   . LEU A 1 145 ? 49.542 12.401  55.789 1.00 46.32  ? 584  LEU A O   1 
ATOM   1112 C  CB  . LEU A 1 145 ? 49.424 14.295  53.271 1.00 43.58  ? 584  LEU A CB  1 
ATOM   1113 C  CG  . LEU A 1 145 ? 49.322 13.890  51.805 1.00 43.50  ? 584  LEU A CG  1 
ATOM   1114 C  CD1 . LEU A 1 145 ? 50.380 14.596  50.991 1.00 44.04  ? 584  LEU A CD1 1 
ATOM   1115 C  CD2 . LEU A 1 145 ? 49.454 12.386  51.661 1.00 44.88  ? 584  LEU A CD2 1 
ATOM   1116 N  N   . GLU A 1 146 ? 48.804 14.396  56.509 1.00 44.23  ? 585  GLU A N   1 
ATOM   1117 C  CA  . GLU A 1 146 ? 49.241 14.122  57.870 1.00 45.24  ? 585  GLU A CA  1 
ATOM   1118 C  C   . GLU A 1 146 ? 48.326 13.116  58.548 1.00 45.85  ? 585  GLU A C   1 
ATOM   1119 O  O   . GLU A 1 146 ? 48.787 12.301  59.354 1.00 44.21  ? 585  GLU A O   1 
ATOM   1120 C  CB  . GLU A 1 146 ? 49.296 15.415  58.678 1.00 46.44  ? 585  GLU A CB  1 
ATOM   1121 C  CG  . GLU A 1 146 ? 50.690 15.970  58.837 1.00 48.28  ? 585  GLU A CG  1 
ATOM   1122 C  CD  . GLU A 1 146 ? 50.685 17.448  59.128 1.00 53.20  ? 585  GLU A CD  1 
ATOM   1123 O  OE1 . GLU A 1 146 ? 49.624 17.969  59.531 1.00 53.00  ? 585  GLU A OE1 1 
ATOM   1124 O  OE2 . GLU A 1 146 ? 51.743 18.090  58.958 1.00 57.21  ? 585  GLU A OE2 1 
ATOM   1125 N  N   . ALA A 1 147 ? 47.030 13.162  58.240 1.00 44.14  ? 586  ALA A N   1 
ATOM   1126 C  CA  . ALA A 1 147 ? 46.118 12.169  58.784 1.00 43.44  ? 586  ALA A CA  1 
ATOM   1127 C  C   . ALA A 1 147 ? 46.417 10.791  58.215 1.00 46.48  ? 586  ALA A C   1 
ATOM   1128 O  O   . ALA A 1 147 ? 46.459 9.801   58.956 1.00 47.30  ? 586  ALA A O   1 
ATOM   1129 C  CB  . ALA A 1 147 ? 44.673 12.573  58.500 1.00 43.50  ? 586  ALA A CB  1 
ATOM   1130 N  N   . ILE A 1 148 ? 46.645 10.713  56.904 1.00 44.75  ? 587  ILE A N   1 
ATOM   1131 C  CA  . ILE A 1 148 ? 46.891 9.426   56.269 1.00 42.76  ? 587  ILE A CA  1 
ATOM   1132 C  C   . ILE A 1 148 ? 48.211 8.835   56.749 1.00 44.94  ? 587  ILE A C   1 
ATOM   1133 O  O   . ILE A 1 148 ? 48.319 7.622   56.963 1.00 45.14  ? 587  ILE A O   1 
ATOM   1134 C  CB  . ILE A 1 148 ? 46.843 9.580   54.740 1.00 43.03  ? 587  ILE A CB  1 
ATOM   1135 C  CG1 . ILE A 1 148 ? 45.497 10.178  54.328 1.00 42.70  ? 587  ILE A CG1 1 
ATOM   1136 C  CG2 . ILE A 1 148 ? 47.045 8.244   54.059 1.00 43.25  ? 587  ILE A CG2 1 
ATOM   1137 C  CD1 . ILE A 1 148 ? 45.441 10.634  52.896 1.00 43.83  ? 587  ILE A CD1 1 
ATOM   1138 N  N   . THR A 1 149 ? 49.230 9.677   56.939 1.00 44.42  ? 588  THR A N   1 
ATOM   1139 C  CA  . THR A 1 149 ? 50.481 9.197   57.519 1.00 42.74  ? 588  THR A CA  1 
ATOM   1140 C  C   . THR A 1 149 ? 50.248 8.620   58.907 1.00 46.22  ? 588  THR A C   1 
ATOM   1141 O  O   . THR A 1 149 ? 50.791 7.564   59.250 1.00 49.28  ? 588  THR A O   1 
ATOM   1142 C  CB  . THR A 1 149 ? 51.503 10.327  57.583 1.00 43.05  ? 588  THR A CB  1 
ATOM   1143 O  OG1 . THR A 1 149 ? 51.662 10.901  56.282 1.00 46.33  ? 588  THR A OG1 1 
ATOM   1144 C  CG2 . THR A 1 149 ? 52.836 9.805   58.065 1.00 45.55  ? 588  THR A CG2 1 
ATOM   1145 N  N   . PHE A 1 150 ? 49.436 9.304   59.713 1.00 46.75  ? 589  PHE A N   1 
ATOM   1146 C  CA  . PHE A 1 150 ? 49.091 8.824   61.044 1.00 44.63  ? 589  PHE A CA  1 
ATOM   1147 C  C   . PHE A 1 150 ? 48.379 7.482   60.989 1.00 46.41  ? 589  PHE A C   1 
ATOM   1148 O  O   . PHE A 1 150 ? 48.537 6.656   61.894 1.00 49.08  ? 589  PHE A O   1 
ATOM   1149 C  CB  . PHE A 1 150 ? 48.214 9.866   61.736 1.00 47.63  ? 589  PHE A CB  1 
ATOM   1150 C  CG  . PHE A 1 150 ? 47.923 9.578   63.182 1.00 48.86  ? 589  PHE A CG  1 
ATOM   1151 C  CD1 . PHE A 1 150 ? 48.945 9.277   64.068 1.00 49.00  ? 589  PHE A CD1 1 
ATOM   1152 C  CD2 . PHE A 1 150 ? 46.625 9.647   63.662 1.00 47.74  ? 589  PHE A CD2 1 
ATOM   1153 C  CE1 . PHE A 1 150 ? 48.675 9.032   65.397 1.00 47.64  ? 589  PHE A CE1 1 
ATOM   1154 C  CE2 . PHE A 1 150 ? 46.350 9.403   64.995 1.00 47.46  ? 589  PHE A CE2 1 
ATOM   1155 C  CZ  . PHE A 1 150 ? 47.374 9.096   65.861 1.00 48.45  ? 589  PHE A CZ  1 
ATOM   1156 N  N   . LEU A 1 151 ? 47.589 7.244   59.945 1.00 46.43  ? 590  LEU A N   1 
ATOM   1157 C  CA  . LEU A 1 151 ? 46.857 5.986   59.858 1.00 46.62  ? 590  LEU A CA  1 
ATOM   1158 C  C   . LEU A 1 151 ? 47.752 4.857   59.365 1.00 45.22  ? 590  LEU A C   1 
ATOM   1159 O  O   . LEU A 1 151 ? 47.848 3.805   60.007 1.00 45.15  ? 590  LEU A O   1 
ATOM   1160 C  CB  . LEU A 1 151 ? 45.643 6.146   58.941 1.00 44.87  ? 590  LEU A CB  1 
ATOM   1161 C  CG  . LEU A 1 151 ? 44.542 7.070   59.457 1.00 44.05  ? 590  LEU A CG  1 
ATOM   1162 C  CD1 . LEU A 1 151 ? 43.404 7.157   58.457 1.00 43.48  ? 590  LEU A CD1 1 
ATOM   1163 C  CD2 . LEU A 1 151 ? 44.038 6.568   60.799 1.00 47.03  ? 590  LEU A CD2 1 
ATOM   1164 N  N   . HIS A 1 152 ? 48.427 5.070   58.233 1.00 46.07  ? 591  HIS A N   1 
ATOM   1165 C  CA  . HIS A 1 152 ? 49.194 4.001   57.603 1.00 44.08  ? 591  HIS A CA  1 
ATOM   1166 C  C   . HIS A 1 152 ? 50.396 3.609   58.449 1.00 45.45  ? 591  HIS A C   1 
ATOM   1167 O  O   . HIS A 1 152 ? 50.592 2.429   58.759 1.00 44.76  ? 591  HIS A O   1 
ATOM   1168 C  CB  . HIS A 1 152 ? 49.655 4.430   56.209 1.00 43.29  ? 591  HIS A CB  1 
ATOM   1169 C  CG  . HIS A 1 152 ? 48.542 4.609   55.228 1.00 42.68  ? 591  HIS A CG  1 
ATOM   1170 N  ND1 . HIS A 1 152 ? 48.765 4.776   53.878 1.00 40.76  ? 591  HIS A ND1 1 
ATOM   1171 C  CD2 . HIS A 1 152 ? 47.199 4.653   55.396 1.00 44.30  ? 591  HIS A CD2 1 
ATOM   1172 C  CE1 . HIS A 1 152 ? 47.608 4.914   53.257 1.00 42.26  ? 591  HIS A CE1 1 
ATOM   1173 N  NE2 . HIS A 1 152 ? 46.641 4.842   54.155 1.00 45.09  ? 591  HIS A NE2 1 
ATOM   1174 N  N   . GLU A 1 153 ? 51.215 4.587   58.828 1.00 45.71  ? 592  GLU A N   1 
ATOM   1175 C  CA  . GLU A 1 153 ? 52.526 4.309   59.394 1.00 44.38  ? 592  GLU A CA  1 
ATOM   1176 C  C   . GLU A 1 153 ? 52.554 4.319   60.913 1.00 48.77  ? 592  GLU A C   1 
ATOM   1177 O  O   . GLU A 1 153 ? 53.315 3.550   61.508 1.00 50.75  ? 592  GLU A O   1 
ATOM   1178 C  CB  . GLU A 1 153 ? 53.545 5.314   58.853 1.00 45.75  ? 592  GLU A CB  1 
ATOM   1179 C  CG  . GLU A 1 153 ? 53.605 5.312   57.337 1.00 46.09  ? 592  GLU A CG  1 
ATOM   1180 C  CD  . GLU A 1 153 ? 54.285 6.535   56.770 1.00 48.96  ? 592  GLU A CD  1 
ATOM   1181 O  OE1 . GLU A 1 153 ? 54.979 7.239   57.532 1.00 53.02  ? 592  GLU A OE1 1 
ATOM   1182 O  OE2 . GLU A 1 153 ? 54.120 6.793   55.559 1.00 50.38  ? 592  GLU A OE2 1 
ATOM   1183 N  N   . HIS A 1 154 ? 51.749 5.160   61.557 1.00 49.35  ? 593  HIS A N   1 
ATOM   1184 C  CA  . HIS A 1 154 ? 51.701 5.191   63.010 1.00 48.18  ? 593  HIS A CA  1 
ATOM   1185 C  C   . HIS A 1 154 ? 50.699 4.204   63.593 1.00 49.73  ? 593  HIS A C   1 
ATOM   1186 O  O   . HIS A 1 154 ? 50.721 3.972   64.806 1.00 53.12  ? 593  HIS A O   1 
ATOM   1187 C  CB  . HIS A 1 154 ? 51.349 6.599   63.513 1.00 49.82  ? 593  HIS A CB  1 
ATOM   1188 C  CG  . HIS A 1 154 ? 52.376 7.644   63.194 1.00 52.63  ? 593  HIS A CG  1 
ATOM   1189 N  ND1 . HIS A 1 154 ? 53.189 7.585   62.082 1.00 53.33  ? 593  HIS A ND1 1 
ATOM   1190 C  CD2 . HIS A 1 154 ? 52.706 8.789   63.839 1.00 54.09  ? 593  HIS A CD2 1 
ATOM   1191 C  CE1 . HIS A 1 154 ? 53.980 8.643   62.059 1.00 54.84  ? 593  HIS A CE1 1 
ATOM   1192 N  NE2 . HIS A 1 154 ? 53.707 9.389   63.114 1.00 56.43  ? 593  HIS A NE2 1 
ATOM   1193 N  N   . ASN A 1 155 ? 49.817 3.630   62.772 1.00 46.92  ? 594  ASN A N   1 
ATOM   1194 C  CA  . ASN A 1 155 ? 48.760 2.768   63.288 1.00 48.72  ? 594  ASN A CA  1 
ATOM   1195 C  C   . ASN A 1 155 ? 48.435 1.570   62.411 1.00 49.19  ? 594  ASN A C   1 
ATOM   1196 O  O   . ASN A 1 155 ? 47.656 0.718   62.849 1.00 46.81  ? 594  ASN A O   1 
ATOM   1197 C  CB  . ASN A 1 155 ? 47.476 3.580   63.505 1.00 48.91  ? 594  ASN A CB  1 
ATOM   1198 C  CG  . ASN A 1 155 ? 47.613 4.594   64.622 1.00 52.24  ? 594  ASN A CG  1 
ATOM   1199 O  OD1 . ASN A 1 155 ? 47.389 4.278   65.793 1.00 52.22  ? 594  ASN A OD1 1 
ATOM   1200 N  ND2 . ASN A 1 155 ? 47.989 5.822   64.268 1.00 50.63  ? 594  ASN A ND2 1 
ATOM   1201 N  N   . GLN A 1 156 ? 48.986 1.478   61.198 1.00 48.39  ? 595  GLN A N   1 
ATOM   1202 C  CA  . GLN A 1 156 ? 48.725 0.368   60.281 1.00 48.68  ? 595  GLN A CA  1 
ATOM   1203 C  C   . GLN A 1 156 ? 47.238 0.242   59.964 1.00 46.29  ? 595  GLN A C   1 
ATOM   1204 O  O   . GLN A 1 156 ? 46.694 -0.861  59.875 1.00 48.26  ? 595  GLN A O   1 
ATOM   1205 C  CB  . GLN A 1 156 ? 49.279 -0.946  60.830 1.00 51.02  ? 595  GLN A CB  1 
ATOM   1206 C  CG  . GLN A 1 156 ? 50.749 -0.891  61.185 1.00 51.26  ? 595  GLN A CG  1 
ATOM   1207 C  CD  . GLN A 1 156 ? 51.418 -2.230  60.999 1.00 54.07  ? 595  GLN A CD  1 
ATOM   1208 O  OE1 . GLN A 1 156 ? 51.332 -2.835  59.928 1.00 55.48  ? 595  GLN A OE1 1 
ATOM   1209 N  NE2 . GLN A 1 156 ? 52.081 -2.711  62.044 1.00 54.47  ? 595  GLN A NE2 1 
ATOM   1210 N  N   . ILE A 1 157 ? 46.580 1.382   59.783 1.00 45.10  ? 596  ILE A N   1 
ATOM   1211 C  CA  . ILE A 1 157 ? 45.164 1.441   59.444 1.00 45.41  ? 596  ILE A CA  1 
ATOM   1212 C  C   . ILE A 1 157 ? 45.028 1.965   58.020 1.00 44.99  ? 596  ILE A C   1 
ATOM   1213 O  O   . ILE A 1 157 ? 45.738 2.895   57.618 1.00 44.27  ? 596  ILE A O   1 
ATOM   1214 C  CB  . ILE A 1 157 ? 44.387 2.326   60.440 1.00 44.81  ? 596  ILE A CB  1 
ATOM   1215 C  CG1 . ILE A 1 157 ? 44.273 1.632   61.799 1.00 47.92  ? 596  ILE A CG1 1 
ATOM   1216 C  CG2 . ILE A 1 157 ? 43.008 2.660   59.910 1.00 44.45  ? 596  ILE A CG2 1 
ATOM   1217 C  CD1 . ILE A 1 157 ? 43.872 2.563   62.942 1.00 49.46  ? 596  ILE A CD1 1 
ATOM   1218 N  N   . VAL A 1 158 ? 44.131 1.352   57.249 1.00 45.70  ? 597  VAL A N   1 
ATOM   1219 C  CA  . VAL A 1 158 ? 43.744 1.846   55.932 1.00 43.96  ? 597  VAL A CA  1 
ATOM   1220 C  C   . VAL A 1 158 ? 42.324 2.382   56.042 1.00 43.73  ? 597  VAL A C   1 
ATOM   1221 O  O   . VAL A 1 158 ? 41.465 1.755   56.675 1.00 44.59  ? 597  VAL A O   1 
ATOM   1222 C  CB  . VAL A 1 158 ? 43.862 0.751   54.855 1.00 43.45  ? 597  VAL A CB  1 
ATOM   1223 C  CG1 . VAL A 1 158 ? 42.951 -0.428  55.167 1.00 42.79  ? 597  VAL A CG1 1 
ATOM   1224 C  CG2 . VAL A 1 158 ? 43.574 1.319   53.468 1.00 41.50  ? 597  VAL A CG2 1 
ATOM   1225 N  N   . HIS A 1 159 ? 42.087 3.561   55.465 1.00 42.47  ? 598  HIS A N   1 
ATOM   1226 C  CA  . HIS A 1 159 ? 40.784 4.206   55.602 1.00 43.20  ? 598  HIS A CA  1 
ATOM   1227 C  C   . HIS A 1 159 ? 39.775 3.612   54.630 1.00 42.52  ? 598  HIS A C   1 
ATOM   1228 O  O   . HIS A 1 159 ? 38.647 3.284   55.016 1.00 43.49  ? 598  HIS A O   1 
ATOM   1229 C  CB  . HIS A 1 159 ? 40.922 5.716   55.384 1.00 41.66  ? 598  HIS A CB  1 
ATOM   1230 C  CG  . HIS A 1 159 ? 39.690 6.503   55.719 1.00 43.82  ? 598  HIS A CG  1 
ATOM   1231 N  ND1 . HIS A 1 159 ? 38.572 6.520   54.912 1.00 43.18  ? 598  HIS A ND1 1 
ATOM   1232 C  CD2 . HIS A 1 159 ? 39.412 7.322   56.761 1.00 42.39  ? 598  HIS A CD2 1 
ATOM   1233 C  CE1 . HIS A 1 159 ? 37.655 7.306   55.447 1.00 40.55  ? 598  HIS A CE1 1 
ATOM   1234 N  NE2 . HIS A 1 159 ? 38.141 7.807   56.569 1.00 42.46  ? 598  HIS A NE2 1 
ATOM   1235 N  N   . THR A 1 160 ? 40.173 3.470   53.368 1.00 40.01  ? 599  THR A N   1 
ATOM   1236 C  CA  . THR A 1 160 ? 39.446 2.912   52.234 1.00 40.61  ? 599  THR A CA  1 
ATOM   1237 C  C   . THR A 1 160 ? 38.380 3.858   51.687 1.00 42.58  ? 599  THR A C   1 
ATOM   1238 O  O   . THR A 1 160 ? 37.838 3.578   50.626 1.00 42.13  ? 599  THR A O   1 
ATOM   1239 C  CB  . THR A 1 160 ? 38.783 1.547   52.526 1.00 42.41  ? 599  THR A CB  1 
ATOM   1240 O  OG1 . THR A 1 160 ? 37.669 1.726   53.408 1.00 41.73  ? 599  THR A OG1 1 
ATOM   1241 C  CG2 . THR A 1 160 ? 39.778 0.565   53.146 1.00 41.48  ? 599  THR A CG2 1 
ATOM   1242 N  N   . ASP A 1 161 ? 38.059 4.968   52.353 1.00 43.94  ? 600  ASP A N   1 
ATOM   1243 C  CA  . ASP A 1 161 ? 37.056 5.892   51.828 1.00 42.05  ? 600  ASP A CA  1 
ATOM   1244 C  C   . ASP A 1 161 ? 37.500 7.349   51.989 1.00 42.28  ? 600  ASP A C   1 
ATOM   1245 O  O   . ASP A 1 161 ? 36.810 8.187   52.560 1.00 42.13  ? 600  ASP A O   1 
ATOM   1246 C  CB  . ASP A 1 161 ? 35.699 5.660   52.487 1.00 43.16  ? 600  ASP A CB  1 
ATOM   1247 C  CG  . ASP A 1 161 ? 34.544 5.904   51.530 1.00 47.12  ? 600  ASP A CG  1 
ATOM   1248 O  OD1 . ASP A 1 161 ? 34.783 5.915   50.300 1.00 46.08  ? 600  ASP A OD1 1 
ATOM   1249 O  OD2 . ASP A 1 161 ? 33.404 6.093   52.005 1.00 48.67  ? 600  ASP A OD2 1 
ATOM   1250 N  N   . ILE A 1 162 ? 38.674 7.670   51.454 1.00 41.59  ? 601  ILE A N   1 
ATOM   1251 C  CA  . ILE A 1 162 ? 39.087 9.064   51.350 1.00 42.49  ? 601  ILE A CA  1 
ATOM   1252 C  C   . ILE A 1 162 ? 38.263 9.730   50.254 1.00 44.63  ? 601  ILE A C   1 
ATOM   1253 O  O   . ILE A 1 162 ? 38.308 9.315   49.091 1.00 45.99  ? 601  ILE A O   1 
ATOM   1254 C  CB  . ILE A 1 162 ? 40.588 9.169   51.056 1.00 43.80  ? 601  ILE A CB  1 
ATOM   1255 C  CG1 . ILE A 1 162 ? 41.407 8.489   52.161 1.00 43.27  ? 601  ILE A CG1 1 
ATOM   1256 C  CG2 . ILE A 1 162 ? 40.997 10.622  50.867 1.00 42.26  ? 601  ILE A CG2 1 
ATOM   1257 C  CD1 . ILE A 1 162 ? 41.170 9.050   53.545 1.00 42.39  ? 601  ILE A CD1 1 
ATOM   1258 N  N   . LYS A 1 163 ? 37.500 10.758  50.620 1.00 46.90  ? 602  LYS A N   1 
ATOM   1259 C  CA  . LYS A 1 163 ? 36.690 11.508  49.668 1.00 46.61  ? 602  LYS A CA  1 
ATOM   1260 C  C   . LYS A 1 163 ? 36.307 12.841  50.307 1.00 45.91  ? 602  LYS A C   1 
ATOM   1261 O  O   . LYS A 1 163 ? 36.404 12.994  51.530 1.00 45.12  ? 602  LYS A O   1 
ATOM   1262 C  CB  . LYS A 1 163 ? 35.444 10.710  49.244 1.00 44.17  ? 602  LYS A CB  1 
ATOM   1263 C  CG  . LYS A 1 163 ? 34.508 10.320  50.369 1.00 45.38  ? 602  LYS A CG  1 
ATOM   1264 C  CD  . LYS A 1 163 ? 33.322 9.530   49.832 1.00 44.96  ? 602  LYS A CD  1 
ATOM   1265 C  CE  . LYS A 1 163 ? 32.139 9.568   50.789 1.00 45.66  ? 602  LYS A CE  1 
ATOM   1266 N  NZ  . LYS A 1 163 ? 31.785 8.223   51.319 1.00 44.98  ? 602  LYS A NZ  1 
ATOM   1267 N  N   . PRO A 1 164 ? 35.899 13.833  49.504 1.00 44.30  ? 603  PRO A N   1 
ATOM   1268 C  CA  . PRO A 1 164 ? 35.609 15.163  50.071 1.00 44.76  ? 603  PRO A CA  1 
ATOM   1269 C  C   . PRO A 1 164 ? 34.543 15.162  51.150 1.00 47.80  ? 603  PRO A C   1 
ATOM   1270 O  O   . PRO A 1 164 ? 34.616 15.979  52.077 1.00 47.03  ? 603  PRO A O   1 
ATOM   1271 C  CB  . PRO A 1 164 ? 35.159 15.969  48.847 1.00 45.99  ? 603  PRO A CB  1 
ATOM   1272 C  CG  . PRO A 1 164 ? 35.849 15.318  47.703 1.00 45.61  ? 603  PRO A CG  1 
ATOM   1273 C  CD  . PRO A 1 164 ? 35.880 13.853  48.031 1.00 46.74  ? 603  PRO A CD  1 
ATOM   1274 N  N   . GLU A 1 165 ? 33.546 14.281  51.057 1.00 48.20  ? 604  GLU A N   1 
ATOM   1275 C  CA  . GLU A 1 165 ? 32.521 14.233  52.093 1.00 46.45  ? 604  GLU A CA  1 
ATOM   1276 C  C   . GLU A 1 165 ? 33.106 13.815  53.433 1.00 45.55  ? 604  GLU A C   1 
ATOM   1277 O  O   . GLU A 1 165 ? 32.573 14.188  54.485 1.00 46.43  ? 604  GLU A O   1 
ATOM   1278 C  CB  . GLU A 1 165 ? 31.399 13.280  51.683 1.00 48.61  ? 604  GLU A CB  1 
ATOM   1279 C  CG  . GLU A 1 165 ? 30.757 13.617  50.345 1.00 54.86  ? 604  GLU A CG  1 
ATOM   1280 C  CD  . GLU A 1 165 ? 31.350 12.826  49.186 1.00 54.41  ? 604  GLU A CD  1 
ATOM   1281 O  OE1 . GLU A 1 165 ? 30.801 11.753  48.852 1.00 55.57  ? 604  GLU A OE1 1 
ATOM   1282 O  OE2 . GLU A 1 165 ? 32.360 13.282  48.602 1.00 52.26  ? 604  GLU A OE2 1 
ATOM   1283 N  N   . ASN A 1 166 ? 34.204 13.059  53.418 1.00 42.79  ? 605  ASN A N   1 
ATOM   1284 C  CA  . ASN A 1 166 ? 34.838 12.574  54.634 1.00 43.82  ? 605  ASN A CA  1 
ATOM   1285 C  C   . ASN A 1 166 ? 35.956 13.485  55.119 1.00 43.73  ? 605  ASN A C   1 
ATOM   1286 O  O   . ASN A 1 166 ? 36.820 13.038  55.880 1.00 45.68  ? 605  ASN A O   1 
ATOM   1287 C  CB  . ASN A 1 166 ? 35.369 11.154  54.429 1.00 42.97  ? 605  ASN A CB  1 
ATOM   1288 C  CG  . ASN A 1 166 ? 34.269 10.121  54.438 1.00 42.30  ? 605  ASN A CG  1 
ATOM   1289 O  OD1 . ASN A 1 166 ? 33.174 10.376  54.926 1.00 45.23  ? 605  ASN A OD1 1 
ATOM   1290 N  ND2 . ASN A 1 166 ? 34.553 8.948   53.896 1.00 44.77  ? 605  ASN A ND2 1 
ATOM   1291 N  N   . VAL A 1 167 ? 35.963 14.745  54.695 1.00 43.93  ? 606  VAL A N   1 
ATOM   1292 C  CA  . VAL A 1 167 ? 36.897 15.746  55.193 1.00 43.42  ? 606  VAL A CA  1 
ATOM   1293 C  C   . VAL A 1 167 ? 36.063 16.927  55.673 1.00 45.80  ? 606  VAL A C   1 
ATOM   1294 O  O   . VAL A 1 167 ? 35.427 17.609  54.861 1.00 49.52  ? 606  VAL A O   1 
ATOM   1295 C  CB  . VAL A 1 167 ? 37.910 16.182  54.126 1.00 44.07  ? 606  VAL A CB  1 
ATOM   1296 C  CG1 . VAL A 1 167 ? 38.899 17.177  54.709 1.00 42.75  ? 606  VAL A CG1 1 
ATOM   1297 C  CG2 . VAL A 1 167 ? 38.638 14.969  53.547 1.00 44.37  ? 606  VAL A CG2 1 
ATOM   1298 N  N   . LEU A 1 168 ? 36.052 17.167  56.980 1.00 45.13  ? 607  LEU A N   1 
ATOM   1299 C  CA  . LEU A 1 168 ? 35.238 18.223  57.564 1.00 47.29  ? 607  LEU A CA  1 
ATOM   1300 C  C   . LEU A 1 168 ? 36.104 19.407  57.965 1.00 47.83  ? 607  LEU A C   1 
ATOM   1301 O  O   . LEU A 1 168 ? 37.251 19.247  58.385 1.00 49.48  ? 607  LEU A O   1 
ATOM   1302 C  CB  . LEU A 1 168 ? 34.472 17.725  58.791 1.00 44.18  ? 607  LEU A CB  1 
ATOM   1303 C  CG  . LEU A 1 168 ? 33.515 16.547  58.618 1.00 45.03  ? 607  LEU A CG  1 
ATOM   1304 C  CD1 . LEU A 1 168 ? 32.529 16.484  59.776 1.00 46.59  ? 607  LEU A CD1 1 
ATOM   1305 C  CD2 . LEU A 1 168 ? 32.778 16.628  57.300 1.00 45.04  ? 607  LEU A CD2 1 
ATOM   1306 N  N   . ILE A 1 169 ? 35.537 20.599  57.845 1.00 48.34  ? 608  ILE A N   1 
ATOM   1307 C  CA  . ILE A 1 169 ? 36.222 21.825  58.232 1.00 49.61  ? 608  ILE A CA  1 
ATOM   1308 C  C   . ILE A 1 169 ? 35.887 22.128  59.686 1.00 51.28  ? 608  ILE A C   1 
ATOM   1309 O  O   . ILE A 1 169 ? 34.720 22.067  60.087 1.00 52.52  ? 608  ILE A O   1 
ATOM   1310 C  CB  . ILE A 1 169 ? 35.820 22.991  57.314 1.00 53.04  ? 608  ILE A CB  1 
ATOM   1311 C  CG1 . ILE A 1 169 ? 36.470 22.839  55.936 1.00 53.31  ? 608  ILE A CG1 1 
ATOM   1312 C  CG2 . ILE A 1 169 ? 36.194 24.327  57.938 1.00 57.58  ? 608  ILE A CG2 1 
ATOM   1313 C  CD1 . ILE A 1 169 ? 35.676 21.984  54.981 1.00 50.96  ? 608  ILE A CD1 1 
ATOM   1314 N  N   . VAL A 1 170 ? 36.905 22.432  60.481 1.00 51.37  ? 609  VAL A N   1 
ATOM   1315 C  CA  . VAL A 1 170 ? 36.663 22.816  61.877 1.00 54.83  ? 609  VAL A CA  1 
ATOM   1316 C  C   . VAL A 1 170 ? 35.940 24.160  61.905 1.00 59.90  ? 609  VAL A C   1 
ATOM   1317 O  O   . VAL A 1 170 ? 36.360 25.096  61.202 1.00 62.39  ? 609  VAL A O   1 
ATOM   1318 C  CB  . VAL A 1 170 ? 37.981 22.880  62.647 1.00 54.00  ? 609  VAL A CB  1 
ATOM   1319 C  CG1 . VAL A 1 170 ? 37.718 22.931  64.143 1.00 53.84  ? 609  VAL A CG1 1 
ATOM   1320 C  CG2 . VAL A 1 170 ? 38.846 21.684  62.305 1.00 51.24  ? 609  VAL A CG2 1 
ATOM   1321 N  N   . PRO A 1 171 ? 34.857 24.303  62.678 1.00 60.64  ? 610  PRO A N   1 
ATOM   1322 C  CA  . PRO A 1 171 ? 34.083 25.556  62.636 1.00 63.02  ? 610  PRO A CA  1 
ATOM   1323 C  C   . PRO A 1 171 ? 34.891 26.804  62.948 1.00 68.09  ? 610  PRO A C   1 
ATOM   1324 O  O   . PRO A 1 171 ? 34.563 27.879  62.430 1.00 70.12  ? 610  PRO A O   1 
ATOM   1325 C  CB  . PRO A 1 171 ? 32.989 25.317  63.684 1.00 59.87  ? 610  PRO A CB  1 
ATOM   1326 C  CG  . PRO A 1 171 ? 32.804 23.846  63.690 1.00 59.63  ? 610  PRO A CG  1 
ATOM   1327 C  CD  . PRO A 1 171 ? 34.177 23.266  63.473 1.00 61.34  ? 610  PRO A CD  1 
ATOM   1328 N  N   . SER A 1 172 ? 35.933 26.701  63.777 1.00 67.27  ? 611  SER A N   1 
ATOM   1329 C  CA  . SER A 1 172 ? 36.747 27.875  64.078 1.00 70.19  ? 611  SER A CA  1 
ATOM   1330 C  C   . SER A 1 172 ? 37.452 28.391  62.827 1.00 72.52  ? 611  SER A C   1 
ATOM   1331 O  O   . SER A 1 172 ? 37.602 29.605  62.645 1.00 75.72  ? 611  SER A O   1 
ATOM   1332 C  CB  . SER A 1 172 ? 37.759 27.546  65.176 1.00 71.18  ? 611  SER A CB  1 
ATOM   1333 O  OG  . SER A 1 172 ? 38.917 26.932  64.637 1.00 73.75  ? 611  SER A OG  1 
ATOM   1334 N  N   . SER A 1 173 ? 37.892 27.485  61.952 1.00 70.59  ? 612  SER A N   1 
ATOM   1335 C  CA  . SER A 1 173 ? 38.505 27.904  60.696 1.00 68.96  ? 612  SER A CA  1 
ATOM   1336 C  C   . SER A 1 173 ? 37.472 28.461  59.727 1.00 73.16  ? 612  SER A C   1 
ATOM   1337 O  O   . SER A 1 173 ? 37.788 29.345  58.923 1.00 76.14  ? 612  SER A O   1 
ATOM   1338 C  CB  . SER A 1 173 ? 39.244 26.729  60.060 1.00 64.94  ? 612  SER A CB  1 
ATOM   1339 O  OG  . SER A 1 173 ? 40.517 26.549  60.655 1.00 66.02  ? 612  SER A OG  1 
ATOM   1340 N  N   . TYR A 1 174 ? 36.248 27.946  59.778 1.00 74.68  ? 613  TYR A N   1 
ATOM   1341 C  CA  . TYR A 1 174 ? 35.167 28.457  58.952 1.00 73.83  ? 613  TYR A CA  1 
ATOM   1342 C  C   . TYR A 1 174 ? 34.827 29.892  59.349 1.00 78.71  ? 613  TYR A C   1 
ATOM   1343 O  O   . TYR A 1 174 ? 34.972 30.291  60.509 1.00 76.80  ? 613  TYR A O   1 
ATOM   1344 C  CB  . TYR A 1 174 ? 33.937 27.560  59.092 1.00 72.53  ? 613  TYR A CB  1 
ATOM   1345 C  CG  . TYR A 1 174 ? 33.085 27.466  57.853 1.00 73.52  ? 613  TYR A CG  1 
ATOM   1346 C  CD1 . TYR A 1 174 ? 33.660 27.449  56.590 1.00 77.48  ? 613  TYR A CD1 1 
ATOM   1347 C  CD2 . TYR A 1 174 ? 31.702 27.389  57.944 1.00 76.56  ? 613  TYR A CD2 1 
ATOM   1348 C  CE1 . TYR A 1 174 ? 32.878 27.363  55.446 1.00 78.04  ? 613  TYR A CE1 1 
ATOM   1349 C  CE2 . TYR A 1 174 ? 30.910 27.304  56.809 1.00 77.25  ? 613  TYR A CE2 1 
ATOM   1350 C  CZ  . TYR A 1 174 ? 31.504 27.290  55.562 1.00 77.98  ? 613  TYR A CZ  1 
ATOM   1351 O  OH  . TYR A 1 174 ? 30.725 27.204  54.427 1.00 74.27  ? 613  TYR A OH  1 
ATOM   1352 N  N   . TYR A 1 175 ? 34.384 30.678  58.365 1.00 81.33  ? 614  TYR A N   1 
ATOM   1353 C  CA  . TYR A 1 175 ? 33.978 32.052  58.622 1.00 81.47  ? 614  TYR A CA  1 
ATOM   1354 C  C   . TYR A 1 175 ? 32.479 32.213  58.397 1.00 82.59  ? 614  TYR A C   1 
ATOM   1355 O  O   . TYR A 1 175 ? 31.884 31.481  57.599 1.00 82.73  ? 614  TYR A O   1 
ATOM   1356 C  CB  . TYR A 1 175 ? 34.726 33.044  57.722 1.00 80.95  ? 614  TYR A CB  1 
ATOM   1357 C  CG  . TYR A 1 175 ? 35.804 33.827  58.432 1.00 78.82  ? 614  TYR A CG  1 
ATOM   1358 C  CD1 . TYR A 1 175 ? 37.097 33.881  57.928 1.00 78.92  ? 614  TYR A CD1 1 
ATOM   1359 C  CD2 . TYR A 1 175 ? 35.531 34.509  59.610 1.00 74.68  ? 614  TYR A CD2 1 
ATOM   1360 C  CE1 . TYR A 1 175 ? 38.086 34.593  58.581 1.00 76.88  ? 614  TYR A CE1 1 
ATOM   1361 C  CE2 . TYR A 1 175 ? 36.510 35.223  60.269 1.00 70.36  ? 614  TYR A CE2 1 
ATOM   1362 C  CZ  . TYR A 1 175 ? 37.785 35.263  59.753 1.00 71.99  ? 614  TYR A CZ  1 
ATOM   1363 O  OH  . TYR A 1 175 ? 38.759 35.974  60.416 1.00 67.38  ? 614  TYR A OH  1 
ATOM   1364 N  N   . PRO A 1 176 ? 31.834 33.153  59.094 1.00 82.51  ? 615  PRO A N   1 
ATOM   1365 C  CA  . PRO A 1 176 ? 30.405 33.400  58.838 1.00 81.76  ? 615  PRO A CA  1 
ATOM   1366 C  C   . PRO A 1 176 ? 30.092 33.801  57.403 1.00 83.25  ? 615  PRO A C   1 
ATOM   1367 O  O   . PRO A 1 176 ? 28.919 33.740  57.011 1.00 84.43  ? 615  PRO A O   1 
ATOM   1368 C  CB  . PRO A 1 176 ? 30.066 34.522  59.828 1.00 76.63  ? 615  PRO A CB  1 
ATOM   1369 C  CG  . PRO A 1 176 ? 31.015 34.297  60.959 1.00 73.93  ? 615  PRO A CG  1 
ATOM   1370 C  CD  . PRO A 1 176 ? 32.299 33.844  60.310 1.00 79.30  ? 615  PRO A CD  1 
ATOM   1371 N  N   . ASN A 1 177 ? 31.086 34.210  56.607 1.00 83.94  ? 616  ASN A N   1 
ATOM   1372 C  CA  . ASN A 1 177 ? 30.872 34.382  55.173 1.00 83.25  ? 616  ASN A CA  1 
ATOM   1373 C  C   . ASN A 1 177 ? 31.044 33.076  54.402 1.00 84.70  ? 616  ASN A C   1 
ATOM   1374 O  O   . ASN A 1 177 ? 31.038 33.094  53.165 1.00 86.00  ? 616  ASN A O   1 
ATOM   1375 C  CB  . ASN A 1 177 ? 31.798 35.470  54.608 1.00 80.44  ? 616  ASN A CB  1 
ATOM   1376 C  CG  . ASN A 1 177 ? 33.265 35.225  54.915 1.00 80.93  ? 616  ASN A CG  1 
ATOM   1377 O  OD1 . ASN A 1 177 ? 33.720 34.085  54.987 1.00 83.85  ? 616  ASN A OD1 1 
ATOM   1378 N  ND2 . ASN A 1 177 ? 34.018 36.308  55.083 1.00 75.55  ? 616  ASN A ND2 1 
ATOM   1379 N  N   . ARG A 1 178 ? 31.213 31.960  55.119 1.00 84.49  ? 617  ARG A N   1 
ATOM   1380 C  CA  . ARG A 1 178 ? 31.110 30.606  54.563 1.00 83.69  ? 617  ARG A CA  1 
ATOM   1381 C  C   . ARG A 1 178 ? 32.154 30.343  53.479 1.00 83.14  ? 617  ARG A C   1 
ATOM   1382 O  O   . ARG A 1 178 ? 31.895 29.644  52.497 1.00 83.50  ? 617  ARG A O   1 
ATOM   1383 C  CB  . ARG A 1 178 ? 29.697 30.335  54.040 1.00 83.87  ? 617  ARG A CB  1 
ATOM   1384 C  CG  . ARG A 1 178 ? 28.744 29.804  55.104 1.00 82.28  ? 617  ARG A CG  1 
ATOM   1385 C  CD  . ARG A 1 178 ? 27.752 30.871  55.540 1.00 82.34  ? 617  ARG A CD  1 
ATOM   1386 N  NE  . ARG A 1 178 ? 26.850 30.387  56.582 1.00 85.90  ? 617  ARG A NE  1 
ATOM   1387 C  CZ  . ARG A 1 178 ? 26.088 31.172  57.337 1.00 85.02  ? 617  ARG A CZ  1 
ATOM   1388 N  NH1 . ARG A 1 178 ? 25.300 30.642  58.262 1.00 82.70  ? 617  ARG A NH1 1 
ATOM   1389 N  NH2 . ARG A 1 178 ? 26.113 32.488  57.170 1.00 82.13  ? 617  ARG A NH2 1 
ATOM   1390 N  N   . GLN A 1 179 ? 33.349 30.895  53.663 1.00 81.67  ? 618  GLN A N   1 
ATOM   1391 C  CA  . GLN A 1 179 ? 34.476 30.623  52.784 1.00 79.02  ? 618  GLN A CA  1 
ATOM   1392 C  C   . GLN A 1 179 ? 35.709 30.353  53.631 1.00 75.54  ? 618  GLN A C   1 
ATOM   1393 O  O   . GLN A 1 179 ? 35.926 31.007  54.656 1.00 77.24  ? 618  GLN A O   1 
ATOM   1394 C  CB  . GLN A 1 179 ? 34.733 31.785  51.820 1.00 79.64  ? 618  GLN A CB  1 
ATOM   1395 C  CG  . GLN A 1 179 ? 33.766 31.829  50.650 1.00 81.42  ? 618  GLN A CG  1 
ATOM   1396 C  CD  . GLN A 1 179 ? 34.420 32.322  49.378 1.00 83.80  ? 618  GLN A CD  1 
ATOM   1397 O  OE1 . GLN A 1 179 ? 33.863 32.188  48.287 1.00 84.72  ? 618  GLN A OE1 1 
ATOM   1398 N  NE2 . GLN A 1 179 ? 35.612 32.891  49.509 1.00 81.04  ? 618  GLN A NE2 1 
ATOM   1399 N  N   . ILE A 1 180 ? 36.506 29.382  53.206 1.00 68.44  ? 619  ILE A N   1 
ATOM   1400 C  CA  . ILE A 1 180 ? 37.690 28.967  53.945 1.00 63.51  ? 619  ILE A CA  1 
ATOM   1401 C  C   . ILE A 1 180 ? 38.903 29.694  53.386 1.00 62.81  ? 619  ILE A C   1 
ATOM   1402 O  O   . ILE A 1 180 ? 38.996 29.944  52.179 1.00 63.67  ? 619  ILE A O   1 
ATOM   1403 C  CB  . ILE A 1 180 ? 37.875 27.438  53.889 1.00 61.61  ? 619  ILE A CB  1 
ATOM   1404 C  CG1 . ILE A 1 180 ? 38.091 26.966  52.450 1.00 58.97  ? 619  ILE A CG1 1 
ATOM   1405 C  CG2 . ILE A 1 180 ? 36.672 26.732  54.500 1.00 61.22  ? 619  ILE A CG2 1 
ATOM   1406 C  CD1 . ILE A 1 180 ? 38.282 25.478  52.330 1.00 53.30  ? 619  ILE A CD1 1 
ATOM   1407 N  N   . THR A 1 181 ? 39.818 30.062  54.269 1.00 61.55  ? 620  THR A N   1 
ATOM   1408 C  CA  . THR A 1 181 ? 41.097 30.623  53.881 1.00 59.15  ? 620  THR A CA  1 
ATOM   1409 C  C   . THR A 1 181 ? 42.140 29.511  53.910 1.00 59.45  ? 620  THR A C   1 
ATOM   1410 O  O   . THR A 1 181 ? 41.817 28.337  54.113 1.00 60.36  ? 620  THR A O   1 
ATOM   1411 C  CB  . THR A 1 181 ? 41.468 31.778  54.806 1.00 59.42  ? 620  THR A CB  1 
ATOM   1412 O  OG1 . THR A 1 181 ? 41.957 31.250  56.045 1.00 59.81  ? 620  THR A OG1 1 
ATOM   1413 C  CG2 . THR A 1 181 ? 40.252 32.654  55.078 1.00 60.34  ? 620  THR A CG2 1 
ATOM   1414 N  N   . GLU A 1 182 ? 43.405 29.866  53.712 1.00 57.98  ? 621  GLU A N   1 
ATOM   1415 C  CA  . GLU A 1 182 ? 44.456 28.866  53.834 1.00 57.96  ? 621  GLU A CA  1 
ATOM   1416 C  C   . GLU A 1 182 ? 44.818 28.566  55.284 1.00 59.96  ? 621  GLU A C   1 
ATOM   1417 O  O   . GLU A 1 182 ? 45.658 27.693  55.528 1.00 60.07  ? 621  GLU A O   1 
ATOM   1418 C  CB  . GLU A 1 182 ? 45.700 29.301  53.059 1.00 58.84  ? 621  GLU A CB  1 
ATOM   1419 C  CG  . GLU A 1 182 ? 46.156 30.717  53.329 1.00 64.62  ? 621  GLU A CG  1 
ATOM   1420 C  CD  . GLU A 1 182 ? 47.530 30.984  52.752 1.00 67.94  ? 621  GLU A CD  1 
ATOM   1421 O  OE1 . GLU A 1 182 ? 47.647 31.846  51.855 1.00 68.27  ? 621  GLU A OE1 1 
ATOM   1422 O  OE2 . GLU A 1 182 ? 48.493 30.317  53.188 1.00 68.14  ? 621  GLU A OE2 1 
ATOM   1423 N  N   . HIS A 1 183 ? 44.214 29.259  56.246 1.00 59.04  ? 622  HIS A N   1 
ATOM   1424 C  CA  . HIS A 1 183 ? 44.328 28.896  57.651 1.00 61.22  ? 622  HIS A CA  1 
ATOM   1425 C  C   . HIS A 1 183 ? 43.285 27.867  58.063 1.00 60.46  ? 622  HIS A C   1 
ATOM   1426 O  O   . HIS A 1 183 ? 43.110 27.621  59.262 1.00 60.03  ? 622  HIS A O   1 
ATOM   1427 C  CB  . HIS A 1 183 ? 44.204 30.138  58.542 1.00 61.89  ? 622  HIS A CB  1 
ATOM   1428 C  CG  . HIS A 1 183 ? 45.138 31.247  58.171 1.00 61.47  ? 622  HIS A CG  1 
ATOM   1429 N  ND1 . HIS A 1 183 ? 44.774 32.275  57.328 1.00 62.49  ? 622  HIS A ND1 1 
ATOM   1430 C  CD2 . HIS A 1 183 ? 46.423 31.486  58.525 1.00 59.24  ? 622  HIS A CD2 1 
ATOM   1431 C  CE1 . HIS A 1 183 ? 45.794 33.101  57.180 1.00 64.19  ? 622  HIS A CE1 1 
ATOM   1432 N  NE2 . HIS A 1 183 ? 46.806 32.645  57.896 1.00 64.79  ? 622  HIS A NE2 1 
ATOM   1433 N  N   . VAL A 1 184 ? 42.592 27.267  57.093 1.00 58.29  ? 623  VAL A N   1 
ATOM   1434 C  CA  . VAL A 1 184 ? 41.538 26.308  57.390 1.00 57.81  ? 623  VAL A CA  1 
ATOM   1435 C  C   . VAL A 1 184 ? 42.139 25.057  58.020 1.00 55.10  ? 623  VAL A C   1 
ATOM   1436 O  O   . VAL A 1 184 ? 43.250 24.631  57.676 1.00 53.76  ? 623  VAL A O   1 
ATOM   1437 C  CB  . VAL A 1 184 ? 40.747 25.976  56.111 1.00 56.60  ? 623  VAL A CB  1 
ATOM   1438 C  CG1 . VAL A 1 184 ? 41.627 25.246  55.100 1.00 52.98  ? 623  VAL A CG1 1 
ATOM   1439 C  CG2 . VAL A 1 184 ? 39.499 25.166  56.438 1.00 55.61  ? 623  VAL A CG2 1 
ATOM   1440 N  N   . GLN A 1 185 ? 41.415 24.479  58.973 1.00 55.37  ? 624  GLN A N   1 
ATOM   1441 C  CA  . GLN A 1 185 ? 41.791 23.225  59.608 1.00 53.32  ? 624  GLN A CA  1 
ATOM   1442 C  C   . GLN A 1 185 ? 40.740 22.179  59.272 1.00 51.09  ? 624  GLN A C   1 
ATOM   1443 O  O   . GLN A 1 185 ? 39.540 22.466  59.288 1.00 50.82  ? 624  GLN A O   1 
ATOM   1444 C  CB  . GLN A 1 185 ? 41.923 23.379  61.127 1.00 53.12  ? 624  GLN A CB  1 
ATOM   1445 C  CG  . GLN A 1 185 ? 42.852 24.499  61.568 1.00 53.31  ? 624  GLN A CG  1 
ATOM   1446 C  CD  . GLN A 1 185 ? 44.282 24.290  61.108 1.00 57.48  ? 624  GLN A CD  1 
ATOM   1447 O  OE1 . GLN A 1 185 ? 44.872 23.233  61.334 1.00 57.46  ? 624  GLN A OE1 1 
ATOM   1448 N  NE2 . GLN A 1 185 ? 44.849 25.303  60.457 1.00 57.85  ? 624  GLN A NE2 1 
ATOM   1449 N  N   . VAL A 1 186 ? 41.192 20.970  58.955 1.00 50.77  ? 625  VAL A N   1 
ATOM   1450 C  CA  . VAL A 1 186 ? 40.307 19.914  58.492 1.00 47.96  ? 625  VAL A CA  1 
ATOM   1451 C  C   . VAL A 1 186 ? 40.351 18.747  59.471 1.00 47.75  ? 625  VAL A C   1 
ATOM   1452 O  O   . VAL A 1 186 ? 41.225 18.651  60.334 1.00 47.10  ? 625  VAL A O   1 
ATOM   1453 C  CB  . VAL A 1 186 ? 40.653 19.446  57.067 1.00 46.67  ? 625  VAL A CB  1 
ATOM   1454 C  CG1 . VAL A 1 186 ? 40.557 20.608  56.098 1.00 47.38  ? 625  VAL A CG1 1 
ATOM   1455 C  CG2 . VAL A 1 186 ? 42.043 18.827  57.038 1.00 45.72  ? 625  VAL A CG2 1 
ATOM   1456 N  N   . ARG A 1 187 ? 39.375 17.854  59.317 1.00 47.29  ? 626  ARG A N   1 
ATOM   1457 C  CA  . ARG A 1 187 ? 39.271 16.633  60.100 1.00 46.43  ? 626  ARG A CA  1 
ATOM   1458 C  C   . ARG A 1 187 ? 38.894 15.496  59.167 1.00 46.30  ? 626  ARG A C   1 
ATOM   1459 O  O   . ARG A 1 187 ? 37.925 15.610  58.410 1.00 44.91  ? 626  ARG A O   1 
ATOM   1460 C  CB  . ARG A 1 187 ? 38.224 16.767  61.215 1.00 46.59  ? 626  ARG A CB  1 
ATOM   1461 C  CG  . ARG A 1 187 ? 38.642 17.668  62.361 1.00 46.21  ? 626  ARG A CG  1 
ATOM   1462 C  CD  . ARG A 1 187 ? 39.714 17.019  63.207 1.00 45.92  ? 626  ARG A CD  1 
ATOM   1463 N  NE  . ARG A 1 187 ? 39.800 17.650  64.518 1.00 48.07  ? 626  ARG A NE  1 
ATOM   1464 C  CZ  . ARG A 1 187 ? 40.594 18.676  64.797 1.00 46.92  ? 626  ARG A CZ  1 
ATOM   1465 N  NH1 . ARG A 1 187 ? 41.379 19.184  63.857 1.00 46.83  ? 626  ARG A NH1 1 
ATOM   1466 N  NH2 . ARG A 1 187 ? 40.604 19.193  66.017 1.00 49.92  ? 626  ARG A NH2 1 
ATOM   1467 N  N   . LEU A 1 188 ? 39.667 14.412  59.209 1.00 44.70  ? 627  LEU A N   1 
ATOM   1468 C  CA  . LEU A 1 188 ? 39.316 13.200  58.485 1.00 42.70  ? 627  LEU A CA  1 
ATOM   1469 C  C   . LEU A 1 188 ? 38.319 12.402  59.312 1.00 43.90  ? 627  LEU A C   1 
ATOM   1470 O  O   . LEU A 1 188 ? 38.567 12.119  60.488 1.00 46.10  ? 627  LEU A O   1 
ATOM   1471 C  CB  . LEU A 1 188 ? 40.564 12.365  58.199 1.00 44.81  ? 627  LEU A CB  1 
ATOM   1472 C  CG  . LEU A 1 188 ? 40.353 11.103  57.358 1.00 45.65  ? 627  LEU A CG  1 
ATOM   1473 C  CD1 . LEU A 1 188 ? 39.851 11.471  55.969 1.00 44.51  ? 627  LEU A CD1 1 
ATOM   1474 C  CD2 . LEU A 1 188 ? 41.628 10.265  57.278 1.00 41.45  ? 627  LEU A CD2 1 
ATOM   1475 N  N   . ILE A 1 189 ? 37.187 12.046  58.705 1.00 43.56  ? 628  ILE A N   1 
ATOM   1476 C  CA  . ILE A 1 189 ? 36.097 11.415  59.445 1.00 43.70  ? 628  ILE A CA  1 
ATOM   1477 C  C   . ILE A 1 189 ? 35.732 10.066  58.840 1.00 45.52  ? 628  ILE A C   1 
ATOM   1478 O  O   . ILE A 1 189 ? 36.329 9.630   57.849 1.00 45.16  ? 628  ILE A O   1 
ATOM   1479 C  CB  . ILE A 1 189 ? 34.857 12.328  59.495 1.00 43.74  ? 628  ILE A CB  1 
ATOM   1480 C  CG1 . ILE A 1 189 ? 34.221 12.437  58.109 1.00 42.60  ? 628  ILE A CG1 1 
ATOM   1481 C  CG2 . ILE A 1 189 ? 35.218 13.707  60.022 1.00 44.83  ? 628  ILE A CG2 1 
ATOM   1482 C  CD1 . ILE A 1 189 ? 32.776 12.864  58.133 1.00 41.77  ? 628  ILE A CD1 1 
ATOM   1483 N  N   . ASP A 1 190 ? 34.744 9.404   59.445 1.00 45.15  ? 629  ASP A N   1 
ATOM   1484 C  CA  . ASP A 1 190 ? 34.174 8.153   58.956 1.00 46.68  ? 629  ASP A CA  1 
ATOM   1485 C  C   . ASP A 1 190 ? 35.202 7.033   58.899 1.00 48.94  ? 629  ASP A C   1 
ATOM   1486 O  O   . ASP A 1 190 ? 35.729 6.715   57.828 1.00 46.12  ? 629  ASP A O   1 
ATOM   1487 C  CB  . ASP A 1 190 ? 33.540 8.337   57.577 1.00 47.20  ? 629  ASP A CB  1 
ATOM   1488 C  CG  . ASP A 1 190 ? 32.696 7.146   57.173 1.00 49.55  ? 629  ASP A CG  1 
ATOM   1489 O  OD1 . ASP A 1 190 ? 32.347 7.020   55.979 1.00 51.80  ? 629  ASP A OD1 1 
ATOM   1490 O  OD2 . ASP A 1 190 ? 32.384 6.329   58.064 1.00 51.80  ? 629  ASP A OD2 1 
ATOM   1491 N  N   . PHE A 1 191 ? 35.471 6.410   60.044 1.00 48.18  ? 630  PHE A N   1 
ATOM   1492 C  CA  . PHE A 1 191 ? 36.390 5.286   60.120 1.00 46.77  ? 630  PHE A CA  1 
ATOM   1493 C  C   . PHE A 1 191 ? 35.662 3.954   60.252 1.00 48.71  ? 630  PHE A C   1 
ATOM   1494 O  O   . PHE A 1 191 ? 36.261 2.966   60.688 1.00 49.58  ? 630  PHE A O   1 
ATOM   1495 C  CB  . PHE A 1 191 ? 37.368 5.494   61.275 1.00 46.90  ? 630  PHE A CB  1 
ATOM   1496 C  CG  . PHE A 1 191 ? 38.294 6.652   61.064 1.00 44.78  ? 630  PHE A CG  1 
ATOM   1497 C  CD1 . PHE A 1 191 ? 37.883 7.944   61.343 1.00 45.80  ? 630  PHE A CD1 1 
ATOM   1498 C  CD2 . PHE A 1 191 ? 39.568 6.453   60.561 1.00 44.95  ? 630  PHE A CD2 1 
ATOM   1499 C  CE1 . PHE A 1 191 ? 38.730 9.015   61.133 1.00 44.28  ? 630  PHE A CE1 1 
ATOM   1500 C  CE2 . PHE A 1 191 ? 40.420 7.521   60.351 1.00 42.89  ? 630  PHE A CE2 1 
ATOM   1501 C  CZ  . PHE A 1 191 ? 40.001 8.800   60.637 1.00 42.12  ? 630  PHE A CZ  1 
ATOM   1502 N  N   . GLY A 1 192 ? 34.382 3.907   59.873 1.00 50.69  ? 631  GLY A N   1 
ATOM   1503 C  CA  . GLY A 1 192 ? 33.637 2.662   59.962 1.00 52.72  ? 631  GLY A CA  1 
ATOM   1504 C  C   . GLY A 1 192 ? 34.049 1.643   58.920 1.00 51.27  ? 631  GLY A C   1 
ATOM   1505 O  O   . GLY A 1 192 ? 34.028 0.438   59.184 1.00 53.14  ? 631  GLY A O   1 
ATOM   1506 N  N   . SER A 1 193 ? 34.430 2.106   57.732 1.00 48.41  ? 632  SER A N   1 
ATOM   1507 C  CA  . SER A 1 193 ? 34.918 1.237   56.672 1.00 48.89  ? 632  SER A CA  1 
ATOM   1508 C  C   . SER A 1 193 ? 36.430 1.058   56.710 1.00 48.75  ? 632  SER A C   1 
ATOM   1509 O  O   . SER A 1 193 ? 36.992 0.447   55.796 1.00 46.21  ? 632  SER A O   1 
ATOM   1510 C  CB  . SER A 1 193 ? 34.491 1.781   55.308 1.00 46.64  ? 632  SER A CB  1 
ATOM   1511 O  OG  . SER A 1 193 ? 33.206 2.373   55.384 1.00 49.25  ? 632  SER A OG  1 
ATOM   1512 N  N   . ALA A 1 194 ? 37.096 1.570   57.742 1.00 48.47  ? 633  ALA A N   1 
ATOM   1513 C  CA  . ALA A 1 194 ? 38.533 1.406   57.854 1.00 45.43  ? 633  ALA A CA  1 
ATOM   1514 C  C   . ALA A 1 194 ? 38.877 -0.034  58.230 1.00 49.22  ? 633  ALA A C   1 
ATOM   1515 O  O   . ALA A 1 194 ? 38.009 -0.854  58.545 1.00 52.16  ? 633  ALA A O   1 
ATOM   1516 C  CB  . ALA A 1 194 ? 39.108 2.377   58.880 1.00 45.32  ? 633  ALA A CB  1 
ATOM   1517 N  N   . SER A 1 195 ? 40.174 -0.332  58.208 1.00 48.14  ? 634  SER A N   1 
ATOM   1518 C  CA  . SER A 1 195 ? 40.655 -1.690  58.399 1.00 44.23  ? 634  SER A CA  1 
ATOM   1519 C  C   . SER A 1 195 ? 42.057 -1.644  58.987 1.00 45.75  ? 634  SER A C   1 
ATOM   1520 O  O   . SER A 1 195 ? 42.787 -0.666  58.808 1.00 48.89  ? 634  SER A O   1 
ATOM   1521 C  CB  . SER A 1 195 ? 40.651 -2.462  57.073 1.00 45.29  ? 634  SER A CB  1 
ATOM   1522 O  OG  . SER A 1 195 ? 40.640 -3.861  57.282 1.00 47.78  ? 634  SER A OG  1 
ATOM   1523 N  N   . ARG A 1 196 ? 42.428 -2.705  59.695 1.00 46.58  ? 635  ARG A N   1 
ATOM   1524 C  CA  . ARG A 1 196 ? 43.756 -2.833  60.279 1.00 46.49  ? 635  ARG A CA  1 
ATOM   1525 C  C   . ARG A 1 196 ? 44.545 -3.860  59.477 1.00 47.61  ? 635  ARG A C   1 
ATOM   1526 O  O   . ARG A 1 196 ? 44.158 -5.031  59.407 1.00 47.11  ? 635  ARG A O   1 
ATOM   1527 C  CB  . ARG A 1 196 ? 43.673 -3.238  61.748 1.00 47.33  ? 635  ARG A CB  1 
ATOM   1528 C  CG  . ARG A 1 196 ? 43.300 -2.100  62.672 1.00 48.52  ? 635  ARG A CG  1 
ATOM   1529 C  CD  . ARG A 1 196 ? 44.133 -2.132  63.939 1.00 50.87  ? 635  ARG A CD  1 
ATOM   1530 N  NE  . ARG A 1 196 ? 43.864 -0.995  64.816 1.00 53.15  ? 635  ARG A NE  1 
ATOM   1531 C  CZ  . ARG A 1 196 ? 42.760 -0.859  65.544 1.00 52.06  ? 635  ARG A CZ  1 
ATOM   1532 N  NH1 . ARG A 1 196 ? 41.810 -1.783  65.495 1.00 50.26  ? 635  ARG A NH1 1 
ATOM   1533 N  NH2 . ARG A 1 196 ? 42.604 0.207   66.318 1.00 52.04  ? 635  ARG A NH2 1 
ATOM   1534 N  N   . LEU A 1 197 ? 45.646 -3.418  58.872 1.00 48.81  ? 636  LEU A N   1 
ATOM   1535 C  CA  . LEU A 1 197 ? 46.451 -4.263  58.004 1.00 48.64  ? 636  LEU A CA  1 
ATOM   1536 C  C   . LEU A 1 197 ? 47.726 -4.749  58.680 1.00 48.66  ? 636  LEU A C   1 
ATOM   1537 O  O   . LEU A 1 197 ? 48.668 -5.151  57.989 1.00 48.09  ? 636  LEU A O   1 
ATOM   1538 C  CB  . LEU A 1 197 ? 46.794 -3.514  56.715 1.00 49.36  ? 636  LEU A CB  1 
ATOM   1539 C  CG  . LEU A 1 197 ? 45.651 -2.827  55.967 1.00 45.42  ? 636  LEU A CG  1 
ATOM   1540 C  CD1 . LEU A 1 197 ? 46.176 -2.118  54.729 1.00 44.08  ? 636  LEU A CD1 1 
ATOM   1541 C  CD2 . LEU A 1 197 ? 44.583 -3.831  55.589 1.00 43.59  ? 636  LEU A CD2 1 
ATOM   1542 N  N   . ASP A 1 198 ? 47.776 -4.720  60.016 1.00 48.25  ? 637  ASP A N   1 
ATOM   1543 C  CA  . ASP A 1 198 ? 48.989 -5.134  60.714 1.00 50.45  ? 637  ASP A CA  1 
ATOM   1544 C  C   . ASP A 1 198 ? 49.228 -6.634  60.593 1.00 50.55  ? 637  ASP A C   1 
ATOM   1545 O  O   . ASP A 1 198 ? 50.382 -7.073  60.584 1.00 52.80  ? 637  ASP A O   1 
ATOM   1546 C  CB  . ASP A 1 198 ? 48.922 -4.724  62.186 1.00 49.81  ? 637  ASP A CB  1 
ATOM   1547 C  CG  . ASP A 1 198 ? 47.755 -5.356  62.915 1.00 50.99  ? 637  ASP A CG  1 
ATOM   1548 O  OD1 . ASP A 1 198 ? 46.613 -5.243  62.423 1.00 49.57  ? 637  ASP A OD1 1 
ATOM   1549 O  OD2 . ASP A 1 198 ? 47.978 -5.971  63.978 1.00 56.23  ? 637  ASP A OD2 1 
ATOM   1550 N  N   . LYS A 1 199 ? 48.167 -7.434  60.498 1.00 49.54  ? 638  LYS A N   1 
ATOM   1551 C  CA  . LYS A 1 199 ? 48.303 -8.878  60.353 1.00 49.51  ? 638  LYS A CA  1 
ATOM   1552 C  C   . LYS A 1 199 ? 48.012 -9.348  58.936 1.00 49.41  ? 638  LYS A C   1 
ATOM   1553 O  O   . LYS A 1 199 ? 48.766 -10.151 58.380 1.00 49.91  ? 638  LYS A O   1 
ATOM   1554 C  CB  . LYS A 1 199 ? 47.379 -9.602  61.339 1.00 51.28  ? 638  LYS A CB  1 
ATOM   1555 C  CG  . LYS A 1 199 ? 47.268 -8.934  62.700 1.00 53.22  ? 638  LYS A CG  1 
ATOM   1556 C  CD  . LYS A 1 199 ? 47.365 -9.952  63.822 1.00 52.49  ? 638  LYS A CD  1 
ATOM   1557 C  CE  . LYS A 1 199 ? 46.827 -9.385  65.123 1.00 54.96  ? 638  LYS A CE  1 
ATOM   1558 N  NZ  . LYS A 1 199 ? 47.182 -10.250 66.279 1.00 56.97  ? 638  LYS A NZ  1 
ATOM   1559 N  N   . VAL A 1 200 ? 46.930 -8.860  58.342 1.00 47.23  ? 639  VAL A N   1 
ATOM   1560 C  CA  . VAL A 1 200 ? 46.558 -9.180  56.972 1.00 45.18  ? 639  VAL A CA  1 
ATOM   1561 C  C   . VAL A 1 200 ? 46.593 -7.864  56.204 1.00 48.58  ? 639  VAL A C   1 
ATOM   1562 O  O   . VAL A 1 200 ? 45.664 -7.052  56.306 1.00 49.51  ? 639  VAL A O   1 
ATOM   1563 C  CB  . VAL A 1 200 ? 45.182 -9.846  56.891 1.00 46.79  ? 639  VAL A CB  1 
ATOM   1564 C  CG1 . VAL A 1 200 ? 44.758 -10.033 55.442 1.00 46.11  ? 639  VAL A CG1 1 
ATOM   1565 C  CG2 . VAL A 1 200 ? 45.200 -11.174 57.628 1.00 49.08  ? 639  VAL A CG2 1 
ATOM   1566 N  N   . SER A 1 201 ? 47.665 -7.641  55.438 1.00 46.71  ? 640  SER A N   1 
ATOM   1567 C  CA  . SER A 1 201 ? 47.884 -6.352  54.793 1.00 48.43  ? 640  SER A CA  1 
ATOM   1568 C  C   . SER A 1 201 ? 47.332 -6.269  53.371 1.00 45.39  ? 640  SER A C   1 
ATOM   1569 O  O   . SER A 1 201 ? 47.320 -5.175  52.797 1.00 44.52  ? 640  SER A O   1 
ATOM   1570 C  CB  . SER A 1 201 ? 49.382 -6.014  54.774 1.00 44.91  ? 640  SER A CB  1 
ATOM   1571 O  OG  . SER A 1 201 ? 50.097 -6.892  53.925 1.00 48.86  ? 640  SER A OG  1 
ATOM   1572 N  N   . VAL A 1 202 ? 46.876 -7.377  52.792 1.00 41.71  ? 641  VAL A N   1 
ATOM   1573 C  CA  . VAL A 1 202 ? 46.334 -7.395  51.435 1.00 45.10  ? 641  VAL A CA  1 
ATOM   1574 C  C   . VAL A 1 202 ? 44.929 -7.982  51.489 1.00 44.69  ? 641  VAL A C   1 
ATOM   1575 O  O   . VAL A 1 202 ? 44.739 -9.102  51.979 1.00 43.38  ? 641  VAL A O   1 
ATOM   1576 C  CB  . VAL A 1 202 ? 47.224 -8.202  50.474 1.00 43.49  ? 641  VAL A CB  1 
ATOM   1577 C  CG1 . VAL A 1 202 ? 46.579 -8.287  49.101 1.00 40.92  ? 641  VAL A CG1 1 
ATOM   1578 C  CG2 . VAL A 1 202 ? 48.617 -7.588  50.385 1.00 41.73  ? 641  VAL A CG2 1 
ATOM   1579 N  N   A ARG A 1 203 ? 43.953 -7.231  50.986 0.50 43.46  ? 642  ARG A N   1 
ATOM   1580 N  N   B ARG A 1 203 ? 43.949 -7.227  50.997 0.50 43.28  ? 642  ARG A N   1 
ATOM   1581 C  CA  A ARG A 1 203 ? 42.565 -7.663  50.938 0.50 43.93  ? 642  ARG A CA  1 
ATOM   1582 C  CA  B ARG A 1 203 ? 42.560 -7.663  50.946 0.50 43.80  ? 642  ARG A CA  1 
ATOM   1583 C  C   A ARG A 1 203 ? 42.054 -7.600  49.503 0.50 46.83  ? 642  ARG A C   1 
ATOM   1584 C  C   B ARG A 1 203 ? 42.047 -7.588  49.512 0.50 46.85  ? 642  ARG A C   1 
ATOM   1585 O  O   A ARG A 1 203 ? 42.667 -6.988  48.623 0.50 45.42  ? 642  ARG A O   1 
ATOM   1586 O  O   B ARG A 1 203 ? 42.655 -6.962  48.638 0.50 45.14  ? 642  ARG A O   1 
ATOM   1587 C  CB  A ARG A 1 203 ? 41.684 -6.803  51.851 0.50 43.32  ? 642  ARG A CB  1 
ATOM   1588 C  CB  B ARG A 1 203 ? 41.674 -6.819  51.874 0.50 43.35  ? 642  ARG A CB  1 
ATOM   1589 C  CG  A ARG A 1 203 ? 42.339 -6.390  53.156 0.50 45.23  ? 642  ARG A CG  1 
ATOM   1590 C  CG  B ARG A 1 203 ? 41.978 -6.959  53.365 0.50 44.27  ? 642  ARG A CG  1 
ATOM   1591 C  CD  A ARG A 1 203 ? 42.368 -7.545  54.146 0.50 44.58  ? 642  ARG A CD  1 
ATOM   1592 C  CD  B ARG A 1 203 ? 40.706 -7.164  54.200 0.50 44.59  ? 642  ARG A CD  1 
ATOM   1593 N  NE  A ARG A 1 203 ? 43.068 -7.197  55.379 0.50 42.51  ? 642  ARG A NE  1 
ATOM   1594 N  NE  B ARG A 1 203 ? 39.649 -6.210  53.869 0.50 42.75  ? 642  ARG A NE  1 
ATOM   1595 C  CZ  A ARG A 1 203 ? 42.463 -6.825  56.501 0.50 42.42  ? 642  ARG A CZ  1 
ATOM   1596 C  CZ  B ARG A 1 203 ? 38.448 -6.187  54.441 0.50 41.48  ? 642  ARG A CZ  1 
ATOM   1597 N  NH1 A ARG A 1 203 ? 41.142 -6.748  56.549 0.50 41.81  ? 642  ARG A NH1 1 
ATOM   1598 N  NH1 B ARG A 1 203 ? 38.139 -7.066  55.383 0.50 42.57  ? 642  ARG A NH1 1 
ATOM   1599 N  NH2 A ARG A 1 203 ? 43.180 -6.532  57.576 0.50 42.36  ? 642  ARG A NH2 1 
ATOM   1600 N  NH2 B ARG A 1 203 ? 37.552 -5.284  54.069 0.50 39.21  ? 642  ARG A NH2 1 
ATOM   1601 N  N   . HIS A 1 204 ? 40.904 -8.237  49.272 1.00 44.47  ? 643  HIS A N   1 
ATOM   1602 C  CA  . HIS A 1 204 ? 40.305 -8.275  47.943 1.00 44.31  ? 643  HIS A CA  1 
ATOM   1603 C  C   . HIS A 1 204 ? 38.838 -7.859  47.931 1.00 46.31  ? 643  HIS A C   1 
ATOM   1604 O  O   . HIS A 1 204 ? 38.185 -7.973  46.887 1.00 48.14  ? 643  HIS A O   1 
ATOM   1605 C  CB  . HIS A 1 204 ? 40.456 -9.671  47.332 1.00 45.24  ? 643  HIS A CB  1 
ATOM   1606 C  CG  . HIS A 1 204 ? 41.880 -10.070 47.112 1.00 44.87  ? 643  HIS A CG  1 
ATOM   1607 N  ND1 . HIS A 1 204 ? 42.636 -10.684 48.087 1.00 41.93  ? 643  HIS A ND1 1 
ATOM   1608 C  CD2 . HIS A 1 204 ? 42.694 -9.920  46.041 1.00 44.65  ? 643  HIS A CD2 1 
ATOM   1609 C  CE1 . HIS A 1 204 ? 43.853 -10.903 47.622 1.00 45.20  ? 643  HIS A CE1 1 
ATOM   1610 N  NE2 . HIS A 1 204 ? 43.915 -10.449 46.383 1.00 45.93  ? 643  HIS A NE2 1 
ATOM   1611 N  N   . ALA A 1 205 ? 38.305 -7.378  49.047 1.00 47.02  ? 644  ALA A N   1 
ATOM   1612 C  CA  . ALA A 1 205 ? 36.930 -6.908  49.064 1.00 45.71  ? 644  ALA A CA  1 
ATOM   1613 C  C   . ALA A 1 205 ? 36.812 -5.596  48.295 1.00 46.87  ? 644  ALA A C   1 
ATOM   1614 O  O   . ALA A 1 205 ? 37.737 -4.781  48.263 1.00 46.89  ? 644  ALA A O   1 
ATOM   1615 C  CB  . ALA A 1 205 ? 36.444 -6.728  50.503 1.00 43.99  ? 644  ALA A CB  1 
ATOM   1616 N  N   . ILE A 1 206 ? 35.662 -5.404  47.655 1.00 47.53  ? 645  ILE A N   1 
ATOM   1617 C  CA  . ILE A 1 206 ? 35.386 -4.152  46.959 1.00 44.62  ? 645  ILE A CA  1 
ATOM   1618 C  C   . ILE A 1 206 ? 35.164 -3.077  48.016 1.00 45.44  ? 645  ILE A C   1 
ATOM   1619 O  O   . ILE A 1 206 ? 34.183 -3.126  48.762 1.00 47.27  ? 645  ILE A O   1 
ATOM   1620 C  CB  . ILE A 1 206 ? 34.177 -4.279  46.024 1.00 47.17  ? 645  ILE A CB  1 
ATOM   1621 C  CG1 . ILE A 1 206 ? 34.515 -5.171  44.826 1.00 49.04  ? 645  ILE A CG1 1 
ATOM   1622 C  CG2 . ILE A 1 206 ? 33.720 -2.908  45.545 1.00 45.55  ? 645  ILE A CG2 1 
ATOM   1623 C  CD1 . ILE A 1 206 ? 33.332 -5.955  44.303 1.00 52.11  ? 645  ILE A CD1 1 
ATOM   1624 N  N   . VAL A 1 207 ? 36.084 -2.113  48.096 1.00 47.19  ? 646  VAL A N   1 
ATOM   1625 C  CA  . VAL A 1 207 ? 35.973 -1.008  49.046 1.00 43.45  ? 646  VAL A CA  1 
ATOM   1626 C  C   . VAL A 1 207 ? 35.969 0.311   48.285 1.00 43.96  ? 646  VAL A C   1 
ATOM   1627 O  O   . VAL A 1 207 ? 36.076 0.324   47.054 1.00 46.75  ? 646  VAL A O   1 
ATOM   1628 C  CB  . VAL A 1 207 ? 37.111 -1.040  50.085 1.00 44.17  ? 646  VAL A CB  1 
ATOM   1629 C  CG1 . VAL A 1 207 ? 36.884 -2.166  51.093 1.00 43.27  ? 646  VAL A CG1 1 
ATOM   1630 C  CG2 . VAL A 1 207 ? 38.461 -1.188  49.400 1.00 42.02  ? 646  VAL A CG2 1 
ATOM   1631 N  N   . SER A 1 208 ? 35.841 1.422   49.016 1.00 44.36  ? 647  SER A N   1 
ATOM   1632 C  CA  . SER A 1 208 ? 35.838 2.775   48.464 1.00 42.39  ? 647  SER A CA  1 
ATOM   1633 C  C   . SER A 1 208 ? 34.594 3.062   47.637 1.00 44.71  ? 647  SER A C   1 
ATOM   1634 O  O   . SER A 1 208 ? 34.074 2.177   46.950 1.00 46.62  ? 647  SER A O   1 
ATOM   1635 C  CB  . SER A 1 208 ? 37.088 3.032   47.612 1.00 45.08  ? 647  SER A CB  1 
ATOM   1636 O  OG  . SER A 1 208 ? 38.273 2.694   48.310 1.00 42.79  ? 647  SER A OG  1 
ATOM   1637 N  N   . THR A 1 209 ? 34.105 4.296   47.701 1.00 46.29  ? 648  THR A N   1 
ATOM   1638 C  CA  . THR A 1 209 ? 33.058 4.706   46.785 1.00 46.54  ? 648  THR A CA  1 
ATOM   1639 C  C   . THR A 1 209 ? 33.609 4.759   45.363 1.00 47.32  ? 648  THR A C   1 
ATOM   1640 O  O   . THR A 1 209 ? 34.813 4.918   45.141 1.00 48.05  ? 648  THR A O   1 
ATOM   1641 C  CB  . THR A 1 209 ? 32.480 6.062   47.187 1.00 47.57  ? 648  THR A CB  1 
ATOM   1642 O  OG1 . THR A 1 209 ? 33.436 7.088   46.910 1.00 50.08  ? 648  THR A OG1 1 
ATOM   1643 C  CG2 . THR A 1 209 ? 32.125 6.080   48.668 1.00 45.48  ? 648  THR A CG2 1 
ATOM   1644 N  N   . ARG A 1 210 ? 32.698 4.632   44.396 1.00 48.97  ? 649  ARG A N   1 
ATOM   1645 C  CA  . ARG A 1 210 ? 33.086 4.378   43.009 1.00 50.12  ? 649  ARG A CA  1 
ATOM   1646 C  C   . ARG A 1 210 ? 34.060 5.430   42.481 1.00 48.25  ? 649  ARG A C   1 
ATOM   1647 O  O   . ARG A 1 210 ? 35.104 5.092   41.913 1.00 47.96  ? 649  ARG A O   1 
ATOM   1648 C  CB  . ARG A 1 210 ? 31.835 4.307   42.134 1.00 49.87  ? 649  ARG A CB  1 
ATOM   1649 C  CG  . ARG A 1 210 ? 32.080 4.583   40.673 1.00 49.92  ? 649  ARG A CG  1 
ATOM   1650 C  CD  . ARG A 1 210 ? 32.853 3.460   40.002 1.00 51.00  ? 649  ARG A CD  1 
ATOM   1651 N  NE  . ARG A 1 210 ? 32.136 2.190   40.052 1.00 52.61  ? 649  ARG A NE  1 
ATOM   1652 C  CZ  . ARG A 1 210 ? 32.607 1.055   39.552 1.00 50.90  ? 649  ARG A CZ  1 
ATOM   1653 N  NH1 . ARG A 1 210 ? 33.794 1.035   38.967 1.00 51.54  ? 649  ARG A NH1 1 
ATOM   1654 N  NH2 . ARG A 1 210 ? 31.895 -0.058  39.638 1.00 54.40  ? 649  ARG A NH2 1 
ATOM   1655 N  N   . HIS A 1 211 ? 33.742 6.713   42.664 1.00 47.45  ? 650  HIS A N   1 
ATOM   1656 C  CA  . HIS A 1 211 ? 34.537 7.758   42.022 1.00 46.90  ? 650  HIS A CA  1 
ATOM   1657 C  C   . HIS A 1 211 ? 35.969 7.822   42.537 1.00 46.07  ? 650  HIS A C   1 
ATOM   1658 O  O   . HIS A 1 211 ? 36.833 8.379   41.851 1.00 46.67  ? 650  HIS A O   1 
ATOM   1659 C  CB  . HIS A 1 211 ? 33.860 9.112   42.202 1.00 47.36  ? 650  HIS A CB  1 
ATOM   1660 C  CG  . HIS A 1 211 ? 32.426 9.116   41.784 1.00 51.77  ? 650  HIS A CG  1 
ATOM   1661 N  ND1 . HIS A 1 211 ? 31.963 8.375   40.718 1.00 52.44  ? 650  HIS A ND1 1 
ATOM   1662 C  CD2 . HIS A 1 211 ? 31.348 9.754   42.297 1.00 53.75  ? 650  HIS A CD2 1 
ATOM   1663 C  CE1 . HIS A 1 211 ? 30.662 8.562   40.588 1.00 55.35  ? 650  HIS A CE1 1 
ATOM   1664 N  NE2 . HIS A 1 211 ? 30.265 9.394   41.533 1.00 56.89  ? 650  HIS A NE2 1 
ATOM   1665 N  N   . TYR A 1 212 ? 36.251 7.259   43.711 1.00 46.28  ? 651  TYR A N   1 
ATOM   1666 C  CA  . TYR A 1 212 ? 37.587 7.325   44.292 1.00 46.19  ? 651  TYR A CA  1 
ATOM   1667 C  C   . TYR A 1 212 ? 38.217 5.944   44.452 1.00 42.95  ? 651  TYR A C   1 
ATOM   1668 O  O   . TYR A 1 212 ? 39.235 5.808   45.137 1.00 42.42  ? 651  TYR A O   1 
ATOM   1669 C  CB  . TYR A 1 212 ? 37.536 8.077   45.626 1.00 44.19  ? 651  TYR A CB  1 
ATOM   1670 C  CG  . TYR A 1 212 ? 36.815 9.406   45.506 1.00 45.44  ? 651  TYR A CG  1 
ATOM   1671 C  CD1 . TYR A 1 212 ? 37.500 10.561  45.141 1.00 43.69  ? 651  TYR A CD1 1 
ATOM   1672 C  CD2 . TYR A 1 212 ? 35.445 9.499   45.725 1.00 44.21  ? 651  TYR A CD2 1 
ATOM   1673 C  CE1 . TYR A 1 212 ? 36.842 11.773  45.016 1.00 44.80  ? 651  TYR A CE1 1 
ATOM   1674 C  CE2 . TYR A 1 212 ? 34.778 10.705  45.599 1.00 43.81  ? 651  TYR A CE2 1 
ATOM   1675 C  CZ  . TYR A 1 212 ? 35.481 11.838  45.243 1.00 45.87  ? 651  TYR A CZ  1 
ATOM   1676 O  OH  . TYR A 1 212 ? 34.822 13.040  45.118 1.00 46.49  ? 651  TYR A OH  1 
ATOM   1677 N  N   . ARG A 1 213 ? 37.656 4.926   43.800 1.00 42.39  ? 652  ARG A N   1 
ATOM   1678 C  CA  . ARG A 1 213 ? 38.119 3.552   43.954 1.00 43.33  ? 652  ARG A CA  1 
ATOM   1679 C  C   . ARG A 1 213 ? 39.361 3.294   43.106 1.00 43.86  ? 652  ARG A C   1 
ATOM   1680 O  O   . ARG A 1 213 ? 39.383 3.601   41.912 1.00 43.67  ? 652  ARG A O   1 
ATOM   1681 C  CB  . ARG A 1 213 ? 37.003 2.584   43.563 1.00 46.53  ? 652  ARG A CB  1 
ATOM   1682 C  CG  . ARG A 1 213 ? 37.349 1.109   43.697 1.00 45.34  ? 652  ARG A CG  1 
ATOM   1683 C  CD  . ARG A 1 213 ? 36.122 0.256   43.435 1.00 46.14  ? 652  ARG A CD  1 
ATOM   1684 N  NE  . ARG A 1 213 ? 34.980 0.704   44.230 1.00 46.27  ? 652  ARG A NE  1 
ATOM   1685 C  CZ  . ARG A 1 213 ? 33.711 0.406   43.961 1.00 50.08  ? 652  ARG A CZ  1 
ATOM   1686 N  NH1 . ARG A 1 213 ? 33.405 -0.346  42.911 1.00 50.58  ? 652  ARG A NH1 1 
ATOM   1687 N  NH2 . ARG A 1 213 ? 32.742 0.862   44.743 1.00 49.82  ? 652  ARG A NH2 1 
ATOM   1688 N  N   . ALA A 1 214 ? 40.387 2.710   43.721 1.00 46.76  ? 653  ALA A N   1 
ATOM   1689 C  CA  . ALA A 1 214 ? 41.635 2.451   43.022 1.00 45.05  ? 653  ALA A CA  1 
ATOM   1690 C  C   . ALA A 1 214 ? 41.479 1.275   42.054 1.00 47.29  ? 653  ALA A C   1 
ATOM   1691 O  O   . ALA A 1 214 ? 40.637 0.397   42.259 1.00 47.14  ? 653  ALA A O   1 
ATOM   1692 C  CB  . ALA A 1 214 ? 42.754 2.161   44.022 1.00 44.63  ? 653  ALA A CB  1 
ATOM   1693 N  N   . PRO A 1 215 ? 42.287 1.236   40.986 1.00 47.26  ? 654  PRO A N   1 
ATOM   1694 C  CA  . PRO A 1 215 ? 42.109 0.173   39.982 1.00 46.34  ? 654  PRO A CA  1 
ATOM   1695 C  C   . PRO A 1 215 ? 42.361 -1.230  40.515 1.00 48.26  ? 654  PRO A C   1 
ATOM   1696 O  O   . PRO A 1 215 ? 41.660 -2.167  40.113 1.00 46.99  ? 654  PRO A O   1 
ATOM   1697 C  CB  . PRO A 1 215 ? 43.112 0.560   38.882 1.00 43.85  ? 654  PRO A CB  1 
ATOM   1698 C  CG  . PRO A 1 215 ? 44.090 1.467   39.544 1.00 44.70  ? 654  PRO A CG  1 
ATOM   1699 C  CD  . PRO A 1 215 ? 43.311 2.214   40.578 1.00 45.82  ? 654  PRO A CD  1 
ATOM   1700 N  N   . GLU A 1 216 ? 43.336 -1.409  41.412 1.00 48.85  ? 655  GLU A N   1 
ATOM   1701 C  CA  . GLU A 1 216 ? 43.617 -2.746  41.928 1.00 46.28  ? 655  GLU A CA  1 
ATOM   1702 C  C   . GLU A 1 216 ? 42.416 -3.330  42.668 1.00 47.41  ? 655  GLU A C   1 
ATOM   1703 O  O   . GLU A 1 216 ? 42.277 -4.555  42.755 1.00 47.83  ? 655  GLU A O   1 
ATOM   1704 C  CB  . GLU A 1 216 ? 44.850 -2.711  42.832 1.00 46.46  ? 655  GLU A CB  1 
ATOM   1705 C  CG  . GLU A 1 216 ? 44.668 -1.939  44.134 1.00 45.38  ? 655  GLU A CG  1 
ATOM   1706 C  CD  . GLU A 1 216 ? 45.053 -0.474  44.009 1.00 47.40  ? 655  GLU A CD  1 
ATOM   1707 O  OE1 . GLU A 1 216 ? 45.161 0.025   42.868 1.00 48.44  ? 655  GLU A OE1 1 
ATOM   1708 O  OE2 . GLU A 1 216 ? 45.241 0.183   45.055 1.00 44.99  ? 655  GLU A OE2 1 
ATOM   1709 N  N   . ILE A 1 217 ? 41.537 -2.477  43.200 1.00 46.27  ? 656  ILE A N   1 
ATOM   1710 C  CA  . ILE A 1 217 ? 40.301 -2.968  43.802 1.00 47.16  ? 656  ILE A CA  1 
ATOM   1711 C  C   . ILE A 1 217 ? 39.368 -3.513  42.729 1.00 48.62  ? 656  ILE A C   1 
ATOM   1712 O  O   . ILE A 1 217 ? 38.704 -4.538  42.922 1.00 48.01  ? 656  ILE A O   1 
ATOM   1713 C  CB  . ILE A 1 217 ? 39.628 -1.855  44.624 1.00 46.06  ? 656  ILE A CB  1 
ATOM   1714 C  CG1 . ILE A 1 217 ? 40.508 -1.460  45.809 1.00 45.49  ? 656  ILE A CG1 1 
ATOM   1715 C  CG2 . ILE A 1 217 ? 38.253 -2.289  45.099 1.00 43.97  ? 656  ILE A CG2 1 
ATOM   1716 C  CD1 . ILE A 1 217 ? 40.260 -0.051  46.291 1.00 43.05  ? 656  ILE A CD1 1 
ATOM   1717 N  N   . ILE A 1 218 ? 39.304 -2.840  41.578 1.00 50.69  ? 657  ILE A N   1 
ATOM   1718 C  CA  . ILE A 1 218 ? 38.472 -3.337  40.486 1.00 52.17  ? 657  ILE A CA  1 
ATOM   1719 C  C   . ILE A 1 218 ? 39.067 -4.603  39.876 1.00 52.19  ? 657  ILE A C   1 
ATOM   1720 O  O   . ILE A 1 218 ? 38.328 -5.504  39.463 1.00 54.53  ? 657  ILE A O   1 
ATOM   1721 C  CB  . ILE A 1 218 ? 38.275 -2.245  39.418 1.00 49.48  ? 657  ILE A CB  1 
ATOM   1722 C  CG1 . ILE A 1 218 ? 37.714 -0.968  40.044 1.00 49.29  ? 657  ILE A CG1 1 
ATOM   1723 C  CG2 . ILE A 1 218 ? 37.344 -2.736  38.329 1.00 52.79  ? 657  ILE A CG2 1 
ATOM   1724 C  CD1 . ILE A 1 218 ? 37.568 0.180   39.065 1.00 47.22  ? 657  ILE A CD1 1 
ATOM   1725 N  N   . LEU A 1 219 ? 40.399 -4.705  39.825 1.00 50.46  ? 658  LEU A N   1 
ATOM   1726 C  CA  . LEU A 1 219 ? 41.060 -5.797  39.117 1.00 51.32  ? 658  LEU A CA  1 
ATOM   1727 C  C   . LEU A 1 219 ? 41.275 -7.038  39.972 1.00 50.73  ? 658  LEU A C   1 
ATOM   1728 O  O   . LEU A 1 219 ? 41.547 -8.110  39.422 1.00 50.89  ? 658  LEU A O   1 
ATOM   1729 C  CB  . LEU A 1 219 ? 42.412 -5.327  38.568 1.00 52.70  ? 658  LEU A CB  1 
ATOM   1730 C  CG  . LEU A 1 219 ? 42.363 -4.136  37.605 1.00 52.06  ? 658  LEU A CG  1 
ATOM   1731 C  CD1 . LEU A 1 219 ? 43.763 -3.639  37.270 1.00 48.48  ? 658  LEU A CD1 1 
ATOM   1732 C  CD2 . LEU A 1 219 ? 41.601 -4.509  36.344 1.00 53.63  ? 658  LEU A CD2 1 
ATOM   1733 N  N   . GLY A 1 220 ? 41.173 -6.924  41.291 1.00 48.76  ? 659  GLY A N   1 
ATOM   1734 C  CA  . GLY A 1 220 ? 41.326 -8.085  42.139 1.00 49.14  ? 659  GLY A CA  1 
ATOM   1735 C  C   . GLY A 1 220 ? 42.748 -8.519  42.390 1.00 47.12  ? 659  GLY A C   1 
ATOM   1736 O  O   . GLY A 1 220 ? 42.968 -9.657  42.812 1.00 46.27  ? 659  GLY A O   1 
ATOM   1737 N  N   . THR A 1 221 ? 43.728 -7.649  42.148 1.00 46.10  ? 660  THR A N   1 
ATOM   1738 C  CA  . THR A 1 221 ? 45.117 -8.006  42.402 1.00 45.09  ? 660  THR A CA  1 
ATOM   1739 C  C   . THR A 1 221 ? 45.501 -7.877  43.869 1.00 43.19  ? 660  THR A C   1 
ATOM   1740 O  O   . THR A 1 221 ? 46.613 -8.272  44.235 1.00 42.55  ? 660  THR A O   1 
ATOM   1741 C  CB  . THR A 1 221 ? 46.058 -7.142  41.558 1.00 43.35  ? 660  THR A CB  1 
ATOM   1742 O  OG1 . THR A 1 221 ? 45.953 -5.774  41.974 1.00 46.27  ? 660  THR A OG1 1 
ATOM   1743 C  CG2 . THR A 1 221 ? 45.711 -7.257  40.080 1.00 44.77  ? 660  THR A CG2 1 
ATOM   1744 N  N   . GLY A 1 222 ? 44.619 -7.332  44.706 1.00 45.07  ? 661  GLY A N   1 
ATOM   1745 C  CA  . GLY A 1 222 ? 44.916 -7.144  46.114 1.00 44.10  ? 661  GLY A CA  1 
ATOM   1746 C  C   . GLY A 1 222 ? 45.216 -5.703  46.469 1.00 44.73  ? 661  GLY A C   1 
ATOM   1747 O  O   . GLY A 1 222 ? 46.113 -5.086  45.885 1.00 48.07  ? 661  GLY A O   1 
ATOM   1748 N  N   . TRP A 1 223 ? 44.476 -5.145  47.419 1.00 44.50  ? 662  TRP A N   1 
ATOM   1749 C  CA  . TRP A 1 223 ? 44.672 -3.758  47.802 1.00 44.54  ? 662  TRP A CA  1 
ATOM   1750 C  C   . TRP A 1 223 ? 45.212 -3.666  49.222 1.00 43.44  ? 662  TRP A C   1 
ATOM   1751 O  O   . TRP A 1 223 ? 45.068 -4.583  50.034 1.00 46.86  ? 662  TRP A O   1 
ATOM   1752 C  CB  . TRP A 1 223 ? 43.376 -2.947  47.667 1.00 43.18  ? 662  TRP A CB  1 
ATOM   1753 C  CG  . TRP A 1 223 ? 42.165 -3.514  48.367 1.00 46.96  ? 662  TRP A CG  1 
ATOM   1754 C  CD1 . TRP A 1 223 ? 41.212 -4.332  47.826 1.00 45.40  ? 662  TRP A CD1 1 
ATOM   1755 C  CD2 . TRP A 1 223 ? 41.759 -3.273  49.724 1.00 44.25  ? 662  TRP A CD2 1 
ATOM   1756 N  NE1 . TRP A 1 223 ? 40.250 -4.623  48.764 1.00 43.45  ? 662  TRP A NE1 1 
ATOM   1757 C  CE2 . TRP A 1 223 ? 40.562 -3.986  49.936 1.00 43.82  ? 662  TRP A CE2 1 
ATOM   1758 C  CE3 . TRP A 1 223 ? 42.298 -2.530  50.782 1.00 42.14  ? 662  TRP A CE3 1 
ATOM   1759 C  CZ2 . TRP A 1 223 ? 39.892 -3.976  51.160 1.00 45.11  ? 662  TRP A CZ2 1 
ATOM   1760 C  CZ3 . TRP A 1 223 ? 41.634 -2.524  51.995 1.00 42.32  ? 662  TRP A CZ3 1 
ATOM   1761 C  CH2 . TRP A 1 223 ? 40.445 -3.245  52.175 1.00 44.79  ? 662  TRP A CH2 1 
ATOM   1762 N  N   . SER A 1 224 ? 45.859 -2.539  49.501 1.00 44.32  ? 663  SER A N   1 
ATOM   1763 C  CA  . SER A 1 224 ? 46.439 -2.291  50.809 1.00 41.34  ? 663  SER A CA  1 
ATOM   1764 C  C   . SER A 1 224 ? 46.377 -0.802  51.115 1.00 42.02  ? 663  SER A C   1 
ATOM   1765 O  O   . SER A 1 224 ? 45.441 -0.114  50.695 1.00 38.60  ? 663  SER A O   1 
ATOM   1766 C  CB  . SER A 1 224 ? 47.879 -2.801  50.861 1.00 41.89  ? 663  SER A CB  1 
ATOM   1767 O  OG  . SER A 1 224 ? 48.398 -2.724  52.176 1.00 42.28  ? 663  SER A OG  1 
ATOM   1768 N  N   . PHE A 1 225 ? 47.380 -0.297  51.834 1.00 43.88  ? 664  PHE A N   1 
ATOM   1769 C  CA  . PHE A 1 225 ? 47.420 1.122   52.169 1.00 40.67  ? 664  PHE A CA  1 
ATOM   1770 C  C   . PHE A 1 225 ? 47.387 2.002   50.925 1.00 42.23  ? 664  PHE A C   1 
ATOM   1771 O  O   . PHE A 1 225 ? 46.827 3.103   50.964 1.00 44.51  ? 664  PHE A O   1 
ATOM   1772 C  CB  . PHE A 1 225 ? 48.669 1.429   52.988 1.00 40.49  ? 664  PHE A CB  1 
ATOM   1773 C  CG  . PHE A 1 225 ? 48.744 0.683   54.283 1.00 41.24  ? 664  PHE A CG  1 
ATOM   1774 C  CD1 . PHE A 1 225 ? 47.993 1.088   55.374 1.00 42.44  ? 664  PHE A CD1 1 
ATOM   1775 C  CD2 . PHE A 1 225 ? 49.576 -0.416  54.419 1.00 41.20  ? 664  PHE A CD2 1 
ATOM   1776 C  CE1 . PHE A 1 225 ? 48.065 0.411   56.575 1.00 43.85  ? 664  PHE A CE1 1 
ATOM   1777 C  CE2 . PHE A 1 225 ? 49.653 -1.097  55.617 1.00 42.16  ? 664  PHE A CE2 1 
ATOM   1778 C  CZ  . PHE A 1 225 ? 48.898 -0.681  56.697 1.00 45.28  ? 664  PHE A CZ  1 
ATOM   1779 N  N   . ALA A 1 226 ? 47.971 1.539   49.815 1.00 41.78  ? 665  ALA A N   1 
ATOM   1780 C  CA  . ALA A 1 226 ? 48.057 2.373   48.624 1.00 40.18  ? 665  ALA A CA  1 
ATOM   1781 C  C   . ALA A 1 226 ? 46.688 2.733   48.074 1.00 42.44  ? 665  ALA A C   1 
ATOM   1782 O  O   . ALA A 1 226 ? 46.568 3.707   47.324 1.00 42.57  ? 665  ALA A O   1 
ATOM   1783 C  CB  . ALA A 1 226 ? 48.879 1.673   47.541 1.00 41.36  ? 665  ALA A CB  1 
ATOM   1784 N  N   . CYS A 1 227 ? 45.645 1.987   48.425 1.00 43.19  ? 666  CYS A N   1 
ATOM   1785 C  CA  . CYS A 1 227 ? 44.326 2.346   47.921 1.00 41.45  ? 666  CYS A CA  1 
ATOM   1786 C  C   . CYS A 1 227 ? 43.892 3.723   48.417 1.00 45.83  ? 666  CYS A C   1 
ATOM   1787 O  O   . CYS A 1 227 ? 43.134 4.413   47.722 1.00 47.35  ? 666  CYS A O   1 
ATOM   1788 C  CB  . CYS A 1 227 ? 43.323 1.242   48.294 1.00 40.79  ? 666  CYS A CB  1 
ATOM   1789 S  SG  . CYS A 1 227 ? 42.407 1.453   49.806 1.00 48.53  ? 666  CYS A SG  1 
ATOM   1790 N  N   . ASP A 1 228 ? 44.402 4.160   49.575 1.00 42.54  ? 667  ASP A N   1 
ATOM   1791 C  CA  . ASP A 1 228 ? 44.064 5.488   50.069 1.00 42.56  ? 667  ASP A CA  1 
ATOM   1792 C  C   . ASP A 1 228 ? 44.778 6.594   49.301 1.00 43.02  ? 667  ASP A C   1 
ATOM   1793 O  O   . ASP A 1 228 ? 44.223 7.687   49.147 1.00 42.07  ? 667  ASP A O   1 
ATOM   1794 C  CB  . ASP A 1 228 ? 44.402 5.619   51.557 1.00 45.63  ? 667  ASP A CB  1 
ATOM   1795 C  CG  . ASP A 1 228 ? 43.307 5.085   52.461 1.00 41.82  ? 667  ASP A CG  1 
ATOM   1796 O  OD1 . ASP A 1 228 ? 42.198 4.803   51.963 1.00 41.48  ? 667  ASP A OD1 1 
ATOM   1797 O  OD2 . ASP A 1 228 ? 43.575 4.920   53.667 1.00 41.27  ? 667  ASP A OD2 1 
ATOM   1798 N  N   . ILE A 1 229 ? 45.999 6.340   48.823 1.00 43.92  ? 668  ILE A N   1 
ATOM   1799 C  CA  . ILE A 1 229 ? 46.754 7.380   48.129 1.00 42.40  ? 668  ILE A CA  1 
ATOM   1800 C  C   . ILE A 1 229 ? 46.095 7.719   46.799 1.00 43.49  ? 668  ILE A C   1 
ATOM   1801 O  O   . ILE A 1 229 ? 46.015 8.892   46.412 1.00 43.29  ? 668  ILE A O   1 
ATOM   1802 C  CB  . ILE A 1 229 ? 48.220 6.943   47.948 1.00 42.46  ? 668  ILE A CB  1 
ATOM   1803 C  CG1 . ILE A 1 229 ? 48.865 6.688   49.311 1.00 41.27  ? 668  ILE A CG1 1 
ATOM   1804 C  CG2 . ILE A 1 229 ? 49.001 7.982   47.174 1.00 41.35  ? 668  ILE A CG2 1 
ATOM   1805 C  CD1 . ILE A 1 229 ? 48.933 7.918   50.195 1.00 44.06  ? 668  ILE A CD1 1 
ATOM   1806 N  N   . TRP A 1 230 ? 45.601 6.704   46.084 1.00 43.22  ? 669  TRP A N   1 
ATOM   1807 C  CA  . TRP A 1 230 ? 44.859 6.964   44.854 1.00 43.77  ? 669  TRP A CA  1 
ATOM   1808 C  C   . TRP A 1 230 ? 43.642 7.836   45.130 1.00 42.82  ? 669  TRP A C   1 
ATOM   1809 O  O   . TRP A 1 230 ? 43.388 8.810   44.412 1.00 42.60  ? 669  TRP A O   1 
ATOM   1810 C  CB  . TRP A 1 230 ? 44.438 5.647   44.198 1.00 43.05  ? 669  TRP A CB  1 
ATOM   1811 C  CG  . TRP A 1 230 ? 43.533 5.824   42.991 1.00 43.08  ? 669  TRP A CG  1 
ATOM   1812 C  CD1 . TRP A 1 230 ? 42.182 6.026   42.998 1.00 42.81  ? 669  TRP A CD1 1 
ATOM   1813 C  CD2 . TRP A 1 230 ? 43.925 5.807   41.610 1.00 45.16  ? 669  TRP A CD2 1 
ATOM   1814 N  NE1 . TRP A 1 230 ? 41.710 6.137   41.711 1.00 43.16  ? 669  TRP A NE1 1 
ATOM   1815 C  CE2 . TRP A 1 230 ? 42.760 6.002   40.842 1.00 44.38  ? 669  TRP A CE2 1 
ATOM   1816 C  CE3 . TRP A 1 230 ? 45.146 5.641   40.950 1.00 45.63  ? 669  TRP A CE3 1 
ATOM   1817 C  CZ2 . TRP A 1 230 ? 42.783 6.038   39.451 1.00 44.66  ? 669  TRP A CZ2 1 
ATOM   1818 C  CZ3 . TRP A 1 230 ? 45.165 5.676   39.571 1.00 43.82  ? 669  TRP A CZ3 1 
ATOM   1819 C  CH2 . TRP A 1 230 ? 43.993 5.874   38.837 1.00 44.42  ? 669  TRP A CH2 1 
ATOM   1820 N  N   . SER A 1 231 ? 42.871 7.493   46.166 1.00 42.32  ? 670  SER A N   1 
ATOM   1821 C  CA  . SER A 1 231 ? 41.720 8.308   46.542 1.00 41.79  ? 670  SER A CA  1 
ATOM   1822 C  C   . SER A 1 231 ? 42.146 9.730   46.873 1.00 41.93  ? 670  SER A C   1 
ATOM   1823 O  O   . SER A 1 231 ? 41.470 10.696  46.496 1.00 40.56  ? 670  SER A O   1 
ATOM   1824 C  CB  . SER A 1 231 ? 41.003 7.677   47.733 1.00 40.28  ? 670  SER A CB  1 
ATOM   1825 O  OG  . SER A 1 231 ? 40.371 6.471   47.356 1.00 41.32  ? 670  SER A OG  1 
ATOM   1826 N  N   . PHE A 1 232 ? 43.271 9.873   47.577 1.00 41.62  ? 671  PHE A N   1 
ATOM   1827 C  CA  . PHE A 1 232 ? 43.806 11.195  47.873 1.00 43.58  ? 671  PHE A CA  1 
ATOM   1828 C  C   . PHE A 1 232 ? 44.108 11.956  46.591 1.00 44.27  ? 671  PHE A C   1 
ATOM   1829 O  O   . PHE A 1 232 ? 43.760 13.134  46.461 1.00 44.63  ? 671  PHE A O   1 
ATOM   1830 C  CB  . PHE A 1 232 ? 45.061 11.067  48.738 1.00 40.54  ? 671  PHE A CB  1 
ATOM   1831 C  CG  . PHE A 1 232 ? 45.819 12.351  48.903 1.00 44.19  ? 671  PHE A CG  1 
ATOM   1832 C  CD1 . PHE A 1 232 ? 45.353 13.344  49.754 1.00 45.07  ? 671  PHE A CD1 1 
ATOM   1833 C  CD2 . PHE A 1 232 ? 47.006 12.565  48.219 1.00 44.50  ? 671  PHE A CD2 1 
ATOM   1834 C  CE1 . PHE A 1 232 ? 46.052 14.529  49.912 1.00 43.53  ? 671  PHE A CE1 1 
ATOM   1835 C  CE2 . PHE A 1 232 ? 47.707 13.746  48.375 1.00 42.98  ? 671  PHE A CE2 1 
ATOM   1836 C  CZ  . PHE A 1 232 ? 47.227 14.727  49.221 1.00 43.61  ? 671  PHE A CZ  1 
ATOM   1837 N  N   . GLY A 1 233 ? 44.747 11.290  45.624 1.00 42.48  ? 672  GLY A N   1 
ATOM   1838 C  CA  . GLY A 1 233 ? 45.104 11.964  44.387 1.00 42.35  ? 672  GLY A CA  1 
ATOM   1839 C  C   . GLY A 1 233 ? 43.890 12.383  43.581 1.00 46.61  ? 672  GLY A C   1 
ATOM   1840 O  O   . GLY A 1 233 ? 43.882 13.448  42.956 1.00 42.58  ? 672  GLY A O   1 
ATOM   1841 N  N   . ALA A 1 234 ? 42.848 11.547  43.576 1.00 43.99  ? 673  ALA A N   1 
ATOM   1842 C  CA  . ALA A 1 234 ? 41.606 11.941  42.926 1.00 44.26  ? 673  ALA A CA  1 
ATOM   1843 C  C   . ALA A 1 234 ? 40.932 13.084  43.672 1.00 43.88  ? 673  ALA A C   1 
ATOM   1844 O  O   . ALA A 1 234 ? 40.294 13.940  43.051 1.00 46.18  ? 673  ALA A O   1 
ATOM   1845 C  CB  . ALA A 1 234 ? 40.665 10.743  42.816 1.00 42.84  ? 673  ALA A CB  1 
ATOM   1846 N  N   . LEU A 1 235 ? 41.061 13.114  44.998 1.00 43.33  ? 674  LEU A N   1 
ATOM   1847 C  CA  . LEU A 1 235 ? 40.506 14.222  45.764 1.00 43.50  ? 674  LEU A CA  1 
ATOM   1848 C  C   . LEU A 1 235 ? 41.201 15.528  45.407 1.00 45.21  ? 674  LEU A C   1 
ATOM   1849 O  O   . LEU A 1 235 ? 40.544 16.559  45.224 1.00 46.38  ? 674  LEU A O   1 
ATOM   1850 C  CB  . LEU A 1 235 ? 40.630 13.929  47.258 1.00 42.62  ? 674  LEU A CB  1 
ATOM   1851 C  CG  . LEU A 1 235 ? 39.944 14.881  48.240 1.00 45.49  ? 674  LEU A CG  1 
ATOM   1852 C  CD1 . LEU A 1 235 ? 39.396 14.093  49.418 1.00 44.86  ? 674  LEU A CD1 1 
ATOM   1853 C  CD2 . LEU A 1 235 ? 40.904 15.966  48.717 1.00 41.48  ? 674  LEU A CD2 1 
ATOM   1854 N  N   . LEU A 1 236 ? 42.532 15.497  45.295 1.00 42.57  ? 675  LEU A N   1 
ATOM   1855 C  CA  . LEU A 1 236 ? 43.289 16.704  44.985 1.00 44.01  ? 675  LEU A CA  1 
ATOM   1856 C  C   . LEU A 1 236 ? 42.882 17.274  43.634 1.00 47.62  ? 675  LEU A C   1 
ATOM   1857 O  O   . LEU A 1 236 ? 42.618 18.476  43.508 1.00 48.30  ? 675  LEU A O   1 
ATOM   1858 C  CB  . LEU A 1 236 ? 44.788 16.404  45.008 1.00 44.68  ? 675  LEU A CB  1 
ATOM   1859 C  CG  . LEU A 1 236 ? 45.446 16.240  46.379 1.00 46.43  ? 675  LEU A CG  1 
ATOM   1860 C  CD1 . LEU A 1 236 ? 46.901 16.672  46.327 1.00 45.92  ? 675  LEU A CD1 1 
ATOM   1861 C  CD2 . LEU A 1 236 ? 44.693 17.027  47.439 1.00 46.53  ? 675  LEU A CD2 1 
ATOM   1862 N  N   . VAL A 1 237 ? 42.825 16.420  42.610 1.00 45.26  ? 676  VAL A N   1 
ATOM   1863 C  CA  . VAL A 1 237 ? 42.398 16.871  41.290 1.00 46.27  ? 676  VAL A CA  1 
ATOM   1864 C  C   . VAL A 1 237 ? 41.005 17.480  41.364 1.00 47.95  ? 676  VAL A C   1 
ATOM   1865 O  O   . VAL A 1 237 ? 40.724 18.508  40.736 1.00 45.77  ? 676  VAL A O   1 
ATOM   1866 C  CB  . VAL A 1 237 ? 42.453 15.709  40.284 1.00 45.23  ? 676  VAL A CB  1 
ATOM   1867 C  CG1 . VAL A 1 237 ? 41.991 16.180  38.924 1.00 49.43  ? 676  VAL A CG1 1 
ATOM   1868 C  CG2 . VAL A 1 237 ? 43.861 15.143  40.200 1.00 44.33  ? 676  VAL A CG2 1 
ATOM   1869 N  N   . GLU A 1 238 ? 40.121 16.867  42.154 1.00 46.96  ? 677  GLU A N   1 
ATOM   1870 C  CA  . GLU A 1 238 ? 38.752 17.358  42.258 1.00 46.06  ? 677  GLU A CA  1 
ATOM   1871 C  C   . GLU A 1 238 ? 38.709 18.762  42.849 1.00 47.80  ? 677  GLU A C   1 
ATOM   1872 O  O   . GLU A 1 238 ? 37.884 19.586  42.441 1.00 49.25  ? 677  GLU A O   1 
ATOM   1873 C  CB  . GLU A 1 238 ? 37.921 16.391  43.095 1.00 48.94  ? 677  GLU A CB  1 
ATOM   1874 C  CG  . GLU A 1 238 ? 36.466 16.764  43.245 1.00 47.55  ? 677  GLU A CG  1 
ATOM   1875 C  CD  . GLU A 1 238 ? 35.658 15.620  43.817 1.00 50.13  ? 677  GLU A CD  1 
ATOM   1876 O  OE1 . GLU A 1 238 ? 35.997 14.450  43.521 1.00 49.27  ? 677  GLU A OE1 1 
ATOM   1877 O  OE2 . GLU A 1 238 ? 34.692 15.885  44.565 1.00 50.11  ? 677  GLU A OE2 1 
ATOM   1878 N  N   . CYS A 1 239 ? 39.594 19.057  43.806 1.00 46.94  ? 678  CYS A N   1 
ATOM   1879 C  CA  . CYS A 1 239 ? 39.662 20.406  44.358 1.00 46.79  ? 678  CYS A CA  1 
ATOM   1880 C  C   . CYS A 1 239 ? 40.253 21.386  43.356 1.00 49.61  ? 678  CYS A C   1 
ATOM   1881 O  O   . CYS A 1 239 ? 39.888 22.567  43.355 1.00 52.39  ? 678  CYS A O   1 
ATOM   1882 C  CB  . CYS A 1 239 ? 40.506 20.412  45.634 1.00 46.55  ? 678  CYS A CB  1 
ATOM   1883 S  SG  . CYS A 1 239 ? 39.832 19.489  47.034 1.00 48.22  ? 678  CYS A SG  1 
ATOM   1884 N  N   . TYR A 1 240 ? 41.164 20.916  42.504 1.00 47.36  ? 679  TYR A N   1 
ATOM   1885 C  CA  . TYR A 1 240 ? 41.807 21.809  41.548 1.00 48.87  ? 679  TYR A CA  1 
ATOM   1886 C  C   . TYR A 1 240 ? 40.847 22.220  40.438 1.00 49.40  ? 679  TYR A C   1 
ATOM   1887 O  O   . TYR A 1 240 ? 40.867 23.370  39.990 1.00 50.62  ? 679  TYR A O   1 
ATOM   1888 C  CB  . TYR A 1 240 ? 43.049 21.144  40.960 1.00 49.46  ? 679  TYR A CB  1 
ATOM   1889 C  CG  . TYR A 1 240 ? 43.852 22.054  40.067 1.00 48.68  ? 679  TYR A CG  1 
ATOM   1890 C  CD1 . TYR A 1 240 ? 44.797 22.918  40.599 1.00 49.88  ? 679  TYR A CD1 1 
ATOM   1891 C  CD2 . TYR A 1 240 ? 43.660 22.055  38.695 1.00 50.99  ? 679  TYR A CD2 1 
ATOM   1892 C  CE1 . TYR A 1 240 ? 45.532 23.755  39.790 1.00 50.61  ? 679  TYR A CE1 1 
ATOM   1893 C  CE2 . TYR A 1 240 ? 44.388 22.890  37.877 1.00 52.50  ? 679  TYR A CE2 1 
ATOM   1894 C  CZ  . TYR A 1 240 ? 45.323 23.738  38.429 1.00 52.00  ? 679  TYR A CZ  1 
ATOM   1895 O  OH  . TYR A 1 240 ? 46.055 24.572  37.616 1.00 54.86  ? 679  TYR A OH  1 
ATOM   1896 N  N   . THR A 1 241 ? 40.001 21.297  39.983 1.00 49.11  ? 680  THR A N   1 
ATOM   1897 C  CA  . THR A 1 241 ? 39.034 21.583  38.933 1.00 48.50  ? 680  THR A CA  1 
ATOM   1898 C  C   . THR A 1 241 ? 37.647 21.914  39.463 1.00 51.01  ? 680  THR A C   1 
ATOM   1899 O  O   . THR A 1 241 ? 36.831 22.462  38.714 1.00 50.88  ? 680  THR A O   1 
ATOM   1900 C  CB  . THR A 1 241 ? 38.918 20.390  37.974 1.00 48.37  ? 680  THR A CB  1 
ATOM   1901 O  OG1 . THR A 1 241 ? 38.227 19.313  38.624 1.00 51.27  ? 680  THR A OG1 1 
ATOM   1902 C  CG2 . THR A 1 241 ? 40.291 19.910  37.554 1.00 47.66  ? 680  THR A CG2 1 
ATOM   1903 N  N   . GLY A 1 242 ? 37.360 21.602  40.727 1.00 51.53  ? 681  GLY A N   1 
ATOM   1904 C  CA  . GLY A 1 242 ? 36.015 21.684  41.247 1.00 50.46  ? 681  GLY A CA  1 
ATOM   1905 C  C   . GLY A 1 242 ? 35.127 20.511  40.892 1.00 52.70  ? 681  GLY A C   1 
ATOM   1906 O  O   . GLY A 1 242 ? 34.031 20.395  41.455 1.00 53.71  ? 681  GLY A O   1 
ATOM   1907 N  N   . GLN A 1 243 ? 35.564 19.626  40.000 1.00 49.71  ? 682  GLN A N   1 
ATOM   1908 C  CA  . GLN A 1 243 ? 34.713 18.586  39.443 1.00 51.66  ? 682  GLN A CA  1 
ATOM   1909 C  C   . GLN A 1 243 ? 35.220 17.204  39.833 1.00 51.39  ? 682  GLN A C   1 
ATOM   1910 O  O   . GLN A 1 243 ? 36.423 16.988  40.005 1.00 52.77  ? 682  GLN A O   1 
ATOM   1911 C  CB  . GLN A 1 243 ? 34.642 18.701  37.912 1.00 53.44  ? 682  GLN A CB  1 
ATOM   1912 C  CG  . GLN A 1 243 ? 33.925 19.949  37.412 1.00 54.80  ? 682  GLN A CG  1 
ATOM   1913 C  CD  . GLN A 1 243 ? 32.418 19.848  37.565 1.00 59.69  ? 682  GLN A CD  1 
ATOM   1914 O  OE1 . GLN A 1 243 ? 31.830 18.793  37.325 1.00 61.18  ? 682  GLN A OE1 1 
ATOM   1915 N  NE2 . GLN A 1 243 ? 31.785 20.944  37.972 1.00 62.44  ? 682  GLN A NE2 1 
ATOM   1916 N  N   . THR A 1 244 ? 34.287 16.266  39.972 1.00 48.01  ? 683  THR A N   1 
ATOM   1917 C  CA  . THR A 1 244 ? 34.661 14.880  40.214 1.00 49.52  ? 683  THR A CA  1 
ATOM   1918 C  C   . THR A 1 244 ? 35.436 14.333  39.020 1.00 48.82  ? 683  THR A C   1 
ATOM   1919 O  O   . THR A 1 244 ? 35.033 14.507  37.867 1.00 48.67  ? 683  THR A O   1 
ATOM   1920 C  CB  . THR A 1 244 ? 33.416 14.036  40.479 1.00 50.04  ? 683  THR A CB  1 
ATOM   1921 O  OG1 . THR A 1 244 ? 32.730 14.548  41.628 1.00 50.67  ? 683  THR A OG1 1 
ATOM   1922 C  CG2 . THR A 1 244 ? 33.797 12.582  40.730 1.00 51.59  ? 683  THR A CG2 1 
ATOM   1923 N  N   . LEU A 1 245 ? 36.557 13.669  39.308 1.00 48.17  ? 684  LEU A N   1 
ATOM   1924 C  CA  . LEU A 1 245 ? 37.476 13.243  38.256 1.00 47.53  ? 684  LEU A CA  1 
ATOM   1925 C  C   . LEU A 1 245 ? 36.894 12.088  37.444 1.00 51.14  ? 684  LEU A C   1 
ATOM   1926 O  O   . LEU A 1 245 ? 36.744 12.189  36.220 1.00 52.91  ? 684  LEU A O   1 
ATOM   1927 C  CB  . LEU A 1 245 ? 38.823 12.858  38.876 1.00 46.70  ? 684  LEU A CB  1 
ATOM   1928 C  CG  . LEU A 1 245 ? 39.988 12.549  37.934 1.00 48.87  ? 684  LEU A CG  1 
ATOM   1929 C  CD1 . LEU A 1 245 ? 40.250 13.726  37.013 1.00 50.23  ? 684  LEU A CD1 1 
ATOM   1930 C  CD2 . LEU A 1 245 ? 41.251 12.179  38.707 1.00 47.18  ? 684  LEU A CD2 1 
ATOM   1931 N  N   . PHE A 1 246 ? 36.554 10.981  38.108 1.00 50.39  ? 685  PHE A N   1 
ATOM   1932 C  CA  . PHE A 1 246 ? 36.030 9.782   37.449 1.00 50.40  ? 685  PHE A CA  1 
ATOM   1933 C  C   . PHE A 1 246 ? 34.518 9.730   37.650 1.00 51.46  ? 685  PHE A C   1 
ATOM   1934 O  O   . PHE A 1 246 ? 34.036 9.323   38.711 1.00 52.03  ? 685  PHE A O   1 
ATOM   1935 C  CB  . PHE A 1 246 ? 36.694 8.523   37.999 1.00 48.78  ? 685  PHE A CB  1 
ATOM   1936 C  CG  . PHE A 1 246 ? 38.187 8.507   37.858 1.00 48.13  ? 685  PHE A CG  1 
ATOM   1937 C  CD1 . PHE A 1 246 ? 38.777 8.383   36.610 1.00 49.86  ? 685  PHE A CD1 1 
ATOM   1938 C  CD2 . PHE A 1 246 ? 39.002 8.605   38.973 1.00 44.96  ? 685  PHE A CD2 1 
ATOM   1939 C  CE1 . PHE A 1 246 ? 40.153 8.366   36.476 1.00 49.60  ? 685  PHE A CE1 1 
ATOM   1940 C  CE2 . PHE A 1 246 ? 40.376 8.589   38.848 1.00 45.59  ? 685  PHE A CE2 1 
ATOM   1941 C  CZ  . PHE A 1 246 ? 40.954 8.468   37.598 1.00 49.22  ? 685  PHE A CZ  1 
ATOM   1942 N  N   . GLN A 1 247 ? 33.768 10.122  36.624 1.00 52.20  ? 686  GLN A N   1 
ATOM   1943 C  CA  . GLN A 1 247 ? 32.306 10.112  36.662 1.00 55.14  ? 686  GLN A CA  1 
ATOM   1944 C  C   . GLN A 1 247 ? 31.816 8.938   35.817 1.00 58.38  ? 686  GLN A C   1 
ATOM   1945 O  O   . GLN A 1 247 ? 31.498 9.079   34.635 1.00 60.70  ? 686  GLN A O   1 
ATOM   1946 C  CB  . GLN A 1 247 ? 31.738 11.452  36.167 1.00 54.47  ? 686  GLN A CB  1 
ATOM   1947 C  CG  . GLN A 1 247 ? 32.315 12.664  36.878 1.00 52.26  ? 686  GLN A CG  1 
ATOM   1948 C  CD  . GLN A 1 247 ? 31.890 13.976  36.244 1.00 53.17  ? 686  GLN A CD  1 
ATOM   1949 O  OE1 . GLN A 1 247 ? 30.708 14.200  35.981 1.00 53.74  ? 686  GLN A OE1 1 
ATOM   1950 N  NE2 . GLN A 1 247 ? 32.857 14.850  35.996 1.00 53.71  ? 686  GLN A NE2 1 
ATOM   1951 N  N   . SER A 1 248 ? 31.759 7.765   36.441 1.00 54.96  ? 687  SER A N   1 
ATOM   1952 C  CA  . SER A 1 248 ? 31.338 6.546   35.767 1.00 56.72  ? 687  SER A CA  1 
ATOM   1953 C  C   . SER A 1 248 ? 31.000 5.515   36.830 1.00 57.90  ? 687  SER A C   1 
ATOM   1954 O  O   . SER A 1 248 ? 31.560 5.538   37.926 1.00 56.55  ? 687  SER A O   1 
ATOM   1955 C  CB  . SER A 1 248 ? 32.422 6.006   34.825 1.00 57.15  ? 687  SER A CB  1 
ATOM   1956 O  OG  . SER A 1 248 ? 32.087 4.713   34.347 1.00 56.54  ? 687  SER A OG  1 
ATOM   1957 N  N   . HIS A 1 249 ? 30.071 4.621   36.504 1.00 56.57  ? 688  HIS A N   1 
ATOM   1958 C  CA  . HIS A 1 249 ? 29.707 3.542   37.408 1.00 56.94  ? 688  HIS A CA  1 
ATOM   1959 C  C   . HIS A 1 249 ? 29.914 2.171   36.791 1.00 55.34  ? 688  HIS A C   1 
ATOM   1960 O  O   . HIS A 1 249 ? 29.633 1.161   37.447 1.00 55.86  ? 688  HIS A O   1 
ATOM   1961 C  CB  . HIS A 1 249 ? 28.252 3.699   37.867 1.00 56.72  ? 688  HIS A CB  1 
ATOM   1962 C  CG  . HIS A 1 249 ? 28.040 4.867   38.780 1.00 61.37  ? 688  HIS A CG  1 
ATOM   1963 N  ND1 . HIS A 1 249 ? 28.508 4.889   40.078 1.00 58.01  ? 688  HIS A ND1 1 
ATOM   1964 C  CD2 . HIS A 1 249 ? 27.421 6.055   38.583 1.00 59.70  ? 688  HIS A CD2 1 
ATOM   1965 C  CE1 . HIS A 1 249 ? 28.181 6.038   40.641 1.00 57.28  ? 688  HIS A CE1 1 
ATOM   1966 N  NE2 . HIS A 1 249 ? 27.521 6.763   39.756 1.00 61.33  ? 688  HIS A NE2 1 
ATOM   1967 N  N   . ASP A 1 250 ? 30.397 2.109   35.557 1.00 55.86  ? 689  ASP A N   1 
ATOM   1968 C  CA  . ASP A 1 250 ? 30.734 0.860   34.896 1.00 55.29  ? 689  ASP A CA  1 
ATOM   1969 C  C   . ASP A 1 250 ? 32.229 0.609   35.037 1.00 53.45  ? 689  ASP A C   1 
ATOM   1970 O  O   . ASP A 1 250 ? 33.041 1.524   34.871 1.00 52.66  ? 689  ASP A O   1 
ATOM   1971 C  CB  . ASP A 1 250 ? 30.327 0.909   33.422 1.00 56.76  ? 689  ASP A CB  1 
ATOM   1972 C  CG  . ASP A 1 250 ? 30.699 -0.349  32.671 1.00 58.20  ? 689  ASP A CG  1 
ATOM   1973 O  OD1 . ASP A 1 250 ? 30.107 -1.414  32.954 1.00 59.12  ? 689  ASP A OD1 1 
ATOM   1974 O  OD2 . ASP A 1 250 ? 31.583 -0.267  31.793 1.00 58.16  ? 689  ASP A OD2 1 
ATOM   1975 N  N   . ASP A 1 251 ? 32.585 -0.636  35.359 1.00 53.73  ? 690  ASP A N   1 
ATOM   1976 C  CA  . ASP A 1 251 ? 33.980 -0.963  35.642 1.00 52.50  ? 690  ASP A CA  1 
ATOM   1977 C  C   . ASP A 1 251 ? 34.864 -0.719  34.423 1.00 53.72  ? 690  ASP A C   1 
ATOM   1978 O  O   . ASP A 1 251 ? 35.935 -0.110  34.531 1.00 52.34  ? 690  ASP A O   1 
ATOM   1979 C  CB  . ASP A 1 251 ? 34.093 -2.416  36.111 1.00 52.09  ? 690  ASP A CB  1 
ATOM   1980 C  CG  . ASP A 1 251 ? 33.790 -2.584  37.594 1.00 52.10  ? 690  ASP A CG  1 
ATOM   1981 O  OD1 . ASP A 1 251 ? 33.707 -1.565  38.314 1.00 52.44  ? 690  ASP A OD1 1 
ATOM   1982 O  OD2 . ASP A 1 251 ? 33.639 -3.741  38.042 1.00 49.96  ? 690  ASP A OD2 1 
ATOM   1983 N  N   . LEU A 1 252 ? 34.425 -1.181  33.249 1.00 54.74  ? 691  LEU A N   1 
ATOM   1984 C  CA  . LEU A 1 252 ? 35.253 -1.067  32.050 1.00 55.87  ? 691  LEU A CA  1 
ATOM   1985 C  C   . LEU A 1 252 ? 35.481 0.391   31.675 1.00 52.80  ? 691  LEU A C   1 
ATOM   1986 O  O   . LEU A 1 252 ? 36.614 0.809   31.411 1.00 52.37  ? 691  LEU A O   1 
ATOM   1987 C  CB  . LEU A 1 252 ? 34.607 -1.824  30.887 1.00 57.95  ? 691  LEU A CB  1 
ATOM   1988 C  CG  . LEU A 1 252 ? 35.313 -1.704  29.532 1.00 58.88  ? 691  LEU A CG  1 
ATOM   1989 C  CD1 . LEU A 1 252 ? 36.506 -2.645  29.454 1.00 58.58  ? 691  LEU A CD1 1 
ATOM   1990 C  CD2 . LEU A 1 252 ? 34.347 -1.965  28.388 1.00 61.65  ? 691  LEU A CD2 1 
ATOM   1991 N  N   . GLU A 1 253 ? 34.408 1.179   31.640 1.00 53.29  ? 692  GLU A N   1 
ATOM   1992 C  CA  . GLU A 1 253 ? 34.539 2.589   31.299 1.00 52.42  ? 692  GLU A CA  1 
ATOM   1993 C  C   . GLU A 1 253 ? 35.369 3.330   32.338 1.00 54.48  ? 692  GLU A C   1 
ATOM   1994 O  O   . GLU A 1 253 ? 36.156 4.223   31.996 1.00 54.32  ? 692  GLU A O   1 
ATOM   1995 C  CB  . GLU A 1 253 ? 33.155 3.211   31.169 1.00 55.56  ? 692  GLU A CB  1 
ATOM   1996 C  CG  . GLU A 1 253 ? 33.138 4.716   31.244 1.00 57.89  ? 692  GLU A CG  1 
ATOM   1997 C  CD  . GLU A 1 253 ? 31.871 5.285   30.670 1.00 61.48  ? 692  GLU A CD  1 
ATOM   1998 O  OE1 . GLU A 1 253 ? 31.796 5.419   29.433 1.00 63.76  ? 692  GLU A OE1 1 
ATOM   1999 O  OE2 . GLU A 1 253 ? 30.943 5.579   31.453 1.00 64.67  ? 692  GLU A OE2 1 
ATOM   2000 N  N   . HIS A 1 254 ? 35.208 2.970   33.615 1.00 56.02  ? 693  HIS A N   1 
ATOM   2001 C  CA  . HIS A 1 254 ? 35.995 3.590   34.676 1.00 52.54  ? 693  HIS A CA  1 
ATOM   2002 C  C   . HIS A 1 254 ? 37.480 3.329   34.479 1.00 52.09  ? 693  HIS A C   1 
ATOM   2003 O  O   . HIS A 1 254 ? 38.307 4.231   34.655 1.00 54.64  ? 693  HIS A O   1 
ATOM   2004 C  CB  . HIS A 1 254 ? 35.531 3.065   36.034 1.00 53.18  ? 693  HIS A CB  1 
ATOM   2005 C  CG  . HIS A 1 254 ? 36.126 3.782   37.204 1.00 51.61  ? 693  HIS A CG  1 
ATOM   2006 N  ND1 . HIS A 1 254 ? 35.901 3.389   38.507 1.00 51.93  ? 693  HIS A ND1 1 
ATOM   2007 C  CD2 . HIS A 1 254 ? 36.933 4.867   37.273 1.00 50.85  ? 693  HIS A CD2 1 
ATOM   2008 C  CE1 . HIS A 1 254 ? 36.546 4.200   39.326 1.00 52.04  ? 693  HIS A CE1 1 
ATOM   2009 N  NE2 . HIS A 1 254 ? 37.179 5.107   38.603 1.00 50.96  ? 693  HIS A NE2 1 
ATOM   2010 N  N   . LEU A 1 255 ? 37.839 2.098   34.110 1.00 52.45  ? 694  LEU A N   1 
ATOM   2011 C  CA  . LEU A 1 255 ? 39.244 1.783   33.880 1.00 53.32  ? 694  LEU A CA  1 
ATOM   2012 C  C   . LEU A 1 255 ? 39.787 2.519   32.664 1.00 52.24  ? 694  LEU A C   1 
ATOM   2013 O  O   . LEU A 1 255 ? 40.959 2.910   32.651 1.00 50.99  ? 694  LEU A O   1 
ATOM   2014 C  CB  . LEU A 1 255 ? 39.423 0.273   33.719 1.00 52.52  ? 694  LEU A CB  1 
ATOM   2015 C  CG  . LEU A 1 255 ? 39.071 -0.576  34.943 1.00 52.68  ? 694  LEU A CG  1 
ATOM   2016 C  CD1 . LEU A 1 255 ? 38.803 -2.018  34.543 1.00 52.55  ? 694  LEU A CD1 1 
ATOM   2017 C  CD2 . LEU A 1 255 ? 40.173 -0.504  35.990 1.00 52.01  ? 694  LEU A CD2 1 
ATOM   2018 N  N   . GLN A 1 256 ? 38.954 2.722   31.642 1.00 54.65  ? 695  GLN A N   1 
ATOM   2019 C  CA  . GLN A 1 256 ? 39.402 3.459   30.467 1.00 54.28  ? 695  GLN A CA  1 
ATOM   2020 C  C   . GLN A 1 256 ? 39.612 4.931   30.793 1.00 54.49  ? 695  GLN A C   1 
ATOM   2021 O  O   . GLN A 1 256 ? 40.549 5.557   30.282 1.00 55.39  ? 695  GLN A O   1 
ATOM   2022 C  CB  . GLN A 1 256 ? 38.401 3.292   29.326 1.00 54.44  ? 695  GLN A CB  1 
ATOM   2023 C  CG  . GLN A 1 256 ? 38.771 4.060   28.071 1.00 59.04  ? 695  GLN A CG  1 
ATOM   2024 C  CD  . GLN A 1 256 ? 40.075 3.583   27.453 1.00 59.09  ? 695  GLN A CD  1 
ATOM   2025 O  OE1 . GLN A 1 256 ? 40.313 2.382   27.320 1.00 57.76  ? 695  GLN A OE1 1 
ATOM   2026 N  NE2 . GLN A 1 256 ? 40.928 4.528   27.072 1.00 57.43  ? 695  GLN A NE2 1 
ATOM   2027 N  N   . LEU A 1 257 ? 38.751 5.502   31.640 1.00 51.14  ? 696  LEU A N   1 
ATOM   2028 C  CA  . LEU A 1 257 ? 38.966 6.874   32.086 1.00 53.64  ? 696  LEU A CA  1 
ATOM   2029 C  C   . LEU A 1 257 ? 40.315 7.012   32.777 1.00 53.03  ? 696  LEU A C   1 
ATOM   2030 O  O   . LEU A 1 257 ? 41.016 8.014   32.594 1.00 53.49  ? 696  LEU A O   1 
ATOM   2031 C  CB  . LEU A 1 257 ? 37.835 7.310   33.019 1.00 53.89  ? 696  LEU A CB  1 
ATOM   2032 C  CG  . LEU A 1 257 ? 36.442 7.438   32.402 1.00 53.21  ? 696  LEU A CG  1 
ATOM   2033 C  CD1 . LEU A 1 257 ? 35.410 7.740   33.472 1.00 52.71  ? 696  LEU A CD1 1 
ATOM   2034 C  CD2 . LEU A 1 257 ? 36.435 8.515   31.339 1.00 55.94  ? 696  LEU A CD2 1 
ATOM   2035 N  N   . MET A 1 258 ? 40.695 6.011   33.577 1.00 53.32  ? 697  MET A N   1 
ATOM   2036 C  CA  . MET A 1 258 ? 42.044 5.972   34.131 1.00 53.63  ? 697  MET A CA  1 
ATOM   2037 C  C   . MET A 1 258 ? 43.081 5.921   33.019 1.00 55.27  ? 697  MET A C   1 
ATOM   2038 O  O   . MET A 1 258 ? 44.090 6.636   33.055 1.00 56.13  ? 697  MET A O   1 
ATOM   2039 C  CB  . MET A 1 258 ? 42.208 4.761   35.051 1.00 51.15  ? 697  MET A CB  1 
ATOM   2040 C  CG  . MET A 1 258 ? 41.247 4.698   36.217 1.00 50.51  ? 697  MET A CG  1 
ATOM   2041 S  SD  . MET A 1 258 ? 41.599 3.265   37.251 1.00 44.15  ? 697  MET A SD  1 
ATOM   2042 C  CE  . MET A 1 258 ? 40.243 3.345   38.418 1.00 46.08  ? 697  MET A CE  1 
ATOM   2043 N  N   . GLN A 1 259 ? 42.850 5.065   32.023 1.00 55.13  ? 698  GLN A N   1 
ATOM   2044 C  CA  . GLN A 1 259 ? 43.772 4.961   30.900 1.00 55.92  ? 698  GLN A CA  1 
ATOM   2045 C  C   . GLN A 1 259 ? 43.876 6.286   30.164 1.00 55.44  ? 698  GLN A C   1 
ATOM   2046 O  O   . GLN A 1 259 ? 44.978 6.766   29.879 1.00 57.61  ? 698  GLN A O   1 
ATOM   2047 C  CB  . GLN A 1 259 ? 43.313 3.852   29.956 1.00 57.44  ? 698  GLN A CB  1 
ATOM   2048 C  CG  . GLN A 1 259 ? 44.309 3.518   28.872 1.00 57.09  ? 698  GLN A CG  1 
ATOM   2049 C  CD  . GLN A 1 259 ? 45.413 2.611   29.365 1.00 62.89  ? 698  GLN A CD  1 
ATOM   2050 O  OE1 . GLN A 1 259 ? 46.483 3.079   29.767 1.00 63.49  ? 698  GLN A OE1 1 
ATOM   2051 N  NE2 . GLN A 1 259 ? 45.164 1.303   29.334 1.00 61.16  ? 698  GLN A NE2 1 
ATOM   2052 N  N   . LYS A 1 260 ? 42.730 6.902   29.867 1.00 56.06  ? 699  LYS A N   1 
ATOM   2053 C  CA  . LYS A 1 260 ? 42.725 8.162   29.134 1.00 55.78  ? 699  LYS A CA  1 
ATOM   2054 C  C   . LYS A 1 260 ? 43.447 9.259   29.908 1.00 58.03  ? 699  LYS A C   1 
ATOM   2055 O  O   . LYS A 1 260 ? 44.203 10.047  29.327 1.00 59.49  ? 699  LYS A O   1 
ATOM   2056 C  CB  . LYS A 1 260 ? 41.286 8.570   28.822 1.00 54.90  ? 699  LYS A CB  1 
ATOM   2057 C  CG  . LYS A 1 260 ? 41.127 9.992   28.319 1.00 58.32  ? 699  LYS A CG  1 
ATOM   2058 C  CD  . LYS A 1 260 ? 41.813 10.192  26.975 1.00 61.99  ? 699  LYS A CD  1 
ATOM   2059 C  CE  . LYS A 1 260 ? 41.525 11.576  26.409 1.00 64.27  ? 699  LYS A CE  1 
ATOM   2060 N  NZ  . LYS A 1 260 ? 40.067 11.814  26.185 1.00 62.96  ? 699  LYS A NZ  1 
ATOM   2061 N  N   . LEU A 1 261 ? 43.245 9.317   31.225 1.00 56.12  ? 700  LEU A N   1 
ATOM   2062 C  CA  . LEU A 1 261 ? 43.847 10.390  32.008 1.00 56.70  ? 700  LEU A CA  1 
ATOM   2063 C  C   . LEU A 1 261 ? 45.363 10.252  32.079 1.00 56.11  ? 700  LEU A C   1 
ATOM   2064 O  O   . LEU A 1 261 ? 46.090 11.243  31.947 1.00 57.50  ? 700  LEU A O   1 
ATOM   2065 C  CB  . LEU A 1 261 ? 43.244 10.411  33.410 1.00 55.99  ? 700  LEU A CB  1 
ATOM   2066 C  CG  . LEU A 1 261 ? 43.909 11.349  34.415 1.00 55.62  ? 700  LEU A CG  1 
ATOM   2067 C  CD1 . LEU A 1 261 ? 43.279 12.730  34.358 1.00 55.03  ? 700  LEU A CD1 1 
ATOM   2068 C  CD2 . LEU A 1 261 ? 43.826 10.766  35.814 1.00 53.26  ? 700  LEU A CD2 1 
ATOM   2069 N  N   . LEU A 1 262 ? 45.860 9.034   32.281 1.00 57.47  ? 701  LEU A N   1 
ATOM   2070 C  CA  . LEU A 1 262 ? 47.276 8.794   32.531 1.00 59.61  ? 701  LEU A CA  1 
ATOM   2071 C  C   . LEU A 1 262 ? 48.031 8.316   31.299 1.00 62.19  ? 701  LEU A C   1 
ATOM   2072 O  O   . LEU A 1 262 ? 49.158 7.827   31.431 1.00 61.83  ? 701  LEU A O   1 
ATOM   2073 C  CB  . LEU A 1 262 ? 47.439 7.771   33.655 1.00 57.68  ? 701  LEU A CB  1 
ATOM   2074 C  CG  . LEU A 1 262 ? 46.805 8.144   34.990 1.00 56.37  ? 701  LEU A CG  1 
ATOM   2075 C  CD1 . LEU A 1 262 ? 46.728 6.921   35.892 1.00 55.23  ? 701  LEU A CD1 1 
ATOM   2076 C  CD2 . LEU A 1 262 ? 47.596 9.262   35.648 1.00 54.03  ? 701  LEU A CD2 1 
ATOM   2077 N  N   . GLN A 1 263 ? 47.444 8.446   30.107 1.00 62.70  ? 702  GLN A N   1 
ATOM   2078 C  CA  . GLN A 1 263 ? 48.041 7.852   28.917 1.00 63.89  ? 702  GLN A CA  1 
ATOM   2079 C  C   . GLN A 1 263 ? 49.338 8.532   28.500 1.00 66.86  ? 702  GLN A C   1 
ATOM   2080 O  O   . GLN A 1 263 ? 50.087 7.961   27.700 1.00 68.52  ? 702  GLN A O   1 
ATOM   2081 C  CB  . GLN A 1 263 ? 47.051 7.883   27.754 1.00 63.74  ? 702  GLN A CB  1 
ATOM   2082 C  CG  . GLN A 1 263 ? 46.874 9.248   27.115 1.00 64.23  ? 702  GLN A CG  1 
ATOM   2083 C  CD  . GLN A 1 263 ? 45.735 9.260   26.120 1.00 65.64  ? 702  GLN A CD  1 
ATOM   2084 O  OE1 . GLN A 1 263 ? 45.158 8.214   25.811 1.00 65.15  ? 702  GLN A OE1 1 
ATOM   2085 N  NE2 . GLN A 1 263 ? 45.401 10.442  25.612 1.00 64.66  ? 702  GLN A NE2 1 
ATOM   2086 N  N   . HIS A 1 264 ? 49.624 9.728   29.007 1.00 65.74  ? 703  HIS A N   1 
ATOM   2087 C  CA  . HIS A 1 264 ? 50.871 10.405  28.686 1.00 66.88  ? 703  HIS A CA  1 
ATOM   2088 C  C   . HIS A 1 264 ? 51.863 10.392  29.839 1.00 69.45  ? 703  HIS A C   1 
ATOM   2089 O  O   . HIS A 1 264 ? 52.983 10.888  29.681 1.00 72.43  ? 703  HIS A O   1 
ATOM   2090 C  CB  . HIS A 1 264 ? 50.594 11.839  28.228 1.00 65.37  ? 703  HIS A CB  1 
ATOM   2091 C  CG  . HIS A 1 264 ? 50.083 11.921  26.824 1.00 66.36  ? 703  HIS A CG  1 
ATOM   2092 N  ND1 . HIS A 1 264 ? 48.786 12.278  26.521 1.00 64.72  ? 703  HIS A ND1 1 
ATOM   2093 C  CD2 . HIS A 1 264 ? 50.690 11.669  25.639 1.00 65.92  ? 703  HIS A CD2 1 
ATOM   2094 C  CE1 . HIS A 1 264 ? 48.621 12.255  25.210 1.00 65.39  ? 703  HIS A CE1 1 
ATOM   2095 N  NE2 . HIS A 1 264 ? 49.761 11.889  24.652 1.00 65.07  ? 703  HIS A NE2 1 
ATOM   2096 N  N   . GLU A 1 265 ? 51.482 9.851   30.991 1.00 70.55  ? 704  GLU A N   1 
ATOM   2097 C  CA  . GLU A 1 265 ? 52.454 9.429   31.990 1.00 71.09  ? 704  GLU A CA  1 
ATOM   2098 C  C   . GLU A 1 265 ? 52.965 8.058   31.575 1.00 73.46  ? 704  GLU A C   1 
ATOM   2099 O  O   . GLU A 1 265 ? 52.188 7.101   31.487 1.00 73.96  ? 704  GLU A O   1 
ATOM   2100 C  CB  . GLU A 1 265 ? 51.825 9.380   33.378 1.00 67.86  ? 704  GLU A CB  1 
ATOM   2101 C  CG  . GLU A 1 265 ? 50.879 10.525  33.658 1.00 64.55  ? 704  GLU A CG  1 
ATOM   2102 C  CD  . GLU A 1 265 ? 51.560 11.867  33.542 1.00 66.65  ? 704  GLU A CD  1 
ATOM   2103 O  OE1 . GLU A 1 265 ? 52.705 11.989  34.028 1.00 64.76  ? 704  GLU A OE1 1 
ATOM   2104 O  OE2 . GLU A 1 265 ? 50.954 12.799  32.970 1.00 67.73  ? 704  GLU A OE2 1 
ATOM   2105 N  N   . ASN A 1 266 ? 54.255 7.961   31.291 1.00 74.22  ? 705  ASN A N   1 
ATOM   2106 C  CA  . ASN A 1 266 ? 54.726 6.752   30.644 1.00 75.67  ? 705  ASN A CA  1 
ATOM   2107 C  C   . ASN A 1 266 ? 54.845 5.614   31.653 1.00 75.50  ? 705  ASN A C   1 
ATOM   2108 O  O   . ASN A 1 266 ? 54.993 5.822   32.861 1.00 74.40  ? 705  ASN A O   1 
ATOM   2109 C  CB  . ASN A 1 266 ? 56.037 7.021   29.913 1.00 79.89  ? 705  ASN A CB  1 
ATOM   2110 C  CG  . ASN A 1 266 ? 55.814 7.712   28.574 1.00 81.38  ? 705  ASN A CG  1 
ATOM   2111 O  OD1 . ASN A 1 266 ? 54.705 7.698   28.029 1.00 79.48  ? 705  ASN A OD1 1 
ATOM   2112 N  ND2 . ASN A 1 266 ? 56.863 8.330   28.045 1.00 80.63  ? 705  ASN A ND2 1 
ATOM   2113 N  N   . GLY A 1 267 ? 54.787 4.392   31.131 1.00 78.63  ? 706  GLY A N   1 
ATOM   2114 C  CA  . GLY A 1 267 ? 54.195 3.322   31.906 1.00 74.41  ? 706  GLY A CA  1 
ATOM   2115 C  C   . GLY A 1 267 ? 52.696 3.555   31.907 1.00 73.56  ? 706  GLY A C   1 
ATOM   2116 O  O   . GLY A 1 267 ? 52.116 3.981   30.901 1.00 73.08  ? 706  GLY A O   1 
ATOM   2117 N  N   . GLU A 1 268 ? 52.062 3.304   33.050 1.00 68.47  ? 707  GLU A N   1 
ATOM   2118 C  CA  . GLU A 1 268 ? 50.684 3.722   33.300 1.00 64.84  ? 707  GLU A CA  1 
ATOM   2119 C  C   . GLU A 1 268 ? 49.734 3.212   32.212 1.00 65.62  ? 707  GLU A C   1 
ATOM   2120 O  O   . GLU A 1 268 ? 49.239 3.955   31.361 1.00 62.14  ? 707  GLU A O   1 
ATOM   2121 C  CB  . GLU A 1 268 ? 50.604 5.246   33.427 1.00 67.45  ? 707  GLU A CB  1 
ATOM   2122 C  CG  . GLU A 1 268 ? 51.218 5.786   34.702 1.00 65.77  ? 707  GLU A CG  1 
ATOM   2123 C  CD  . GLU A 1 268 ? 50.861 4.936   35.902 1.00 60.43  ? 707  GLU A CD  1 
ATOM   2124 O  OE1 . GLU A 1 268 ? 51.761 4.268   36.454 1.00 61.38  ? 707  GLU A OE1 1 
ATOM   2125 O  OE2 . GLU A 1 268 ? 49.672 4.924   36.281 1.00 58.79  ? 707  GLU A OE2 1 
ATOM   2126 N  N   . VAL A 1 269 ? 49.493 1.906   32.272 1.00 63.08  ? 708  VAL A N   1 
ATOM   2127 C  CA  . VAL A 1 269 ? 48.503 1.253   31.431 1.00 59.92  ? 708  VAL A CA  1 
ATOM   2128 C  C   . VAL A 1 269 ? 47.764 0.232   32.280 1.00 58.13  ? 708  VAL A C   1 
ATOM   2129 O  O   . VAL A 1 269 ? 48.330 -0.357  33.206 1.00 57.29  ? 708  VAL A O   1 
ATOM   2130 C  CB  . VAL A 1 269 ? 49.146 0.584   30.202 1.00 63.91  ? 708  VAL A CB  1 
ATOM   2131 C  CG1 . VAL A 1 269 ? 49.361 1.609   29.101 1.00 66.54  ? 708  VAL A CG1 1 
ATOM   2132 C  CG2 . VAL A 1 269 ? 50.462 -0.067  30.594 1.00 62.56  ? 708  VAL A CG2 1 
ATOM   2133 N  N   . ILE A 1 270 ? 46.485 0.031   31.966 1.00 55.55  ? 709  ILE A N   1 
ATOM   2134 C  CA  . ILE A 1 270 ? 45.671 -0.934  32.699 1.00 54.62  ? 709  ILE A CA  1 
ATOM   2135 C  C   . ILE A 1 270 ? 46.100 -2.336  32.278 1.00 54.99  ? 709  ILE A C   1 
ATOM   2136 O  O   . ILE A 1 270 ? 45.915 -2.729  31.124 1.00 56.38  ? 709  ILE A O   1 
ATOM   2137 C  CB  . ILE A 1 270 ? 44.174 -0.719  32.454 1.00 56.42  ? 709  ILE A CB  1 
ATOM   2138 C  CG1 . ILE A 1 270 ? 43.776 0.724   32.765 1.00 56.09  ? 709  ILE A CG1 1 
ATOM   2139 C  CG2 . ILE A 1 270 ? 43.368 -1.683  33.307 1.00 55.85  ? 709  ILE A CG2 1 
ATOM   2140 C  CD1 . ILE A 1 270 ? 43.660 1.018   34.247 1.00 54.44  ? 709  ILE A CD1 1 
ATOM   2141 N  N   . VAL A 1 271 ? 46.657 -3.092  33.212 1.00 56.47  ? 710  VAL A N   1 
ATOM   2142 C  CA  . VAL A 1 271 ? 47.162 -4.443  32.973 1.00 53.69  ? 710  VAL A CA  1 
ATOM   2143 C  C   . VAL A 1 271 ? 46.204 -5.431  33.624 1.00 54.88  ? 710  VAL A C   1 
ATOM   2144 O  O   . VAL A 1 271 ? 45.834 -5.238  34.788 1.00 55.32  ? 710  VAL A O   1 
ATOM   2145 C  CB  . VAL A 1 271 ? 48.587 -4.627  33.530 1.00 52.94  ? 710  VAL A CB  1 
ATOM   2146 C  CG1 . VAL A 1 271 ? 49.087 -6.047  33.277 1.00 53.21  ? 710  VAL A CG1 1 
ATOM   2147 C  CG2 . VAL A 1 271 ? 49.533 -3.596  32.925 1.00 51.82  ? 710  VAL A CG2 1 
ATOM   2148 N  N   . PRO A 1 272 ? 45.792 -6.494  32.929 1.00 57.41  ? 711  PRO A N   1 
ATOM   2149 C  CA  . PRO A 1 272 ? 44.846 -7.435  33.526 1.00 55.44  ? 711  PRO A CA  1 
ATOM   2150 C  C   . PRO A 1 272 ? 45.475 -8.196  34.676 1.00 56.08  ? 711  PRO A C   1 
ATOM   2151 O  O   . PRO A 1 272 ? 46.705 -8.380  34.723 1.00 55.55  ? 711  PRO A O   1 
ATOM   2152 C  CB  . PRO A 1 272 ? 44.501 -8.377  32.357 1.00 57.12  ? 711  PRO A CB  1 
ATOM   2153 C  CG  . PRO A 1 272 ? 45.664 -8.267  31.433 1.00 54.80  ? 711  PRO A CG  1 
ATOM   2154 C  CD  . PRO A 1 272 ? 46.110 -6.841  31.533 1.00 56.04  ? 711  PRO A CD  1 
ATOM   2155 N  N   . PRO A 1 273 ? 44.673 -8.671  35.627 1.00 55.22  ? 712  PRO A N   1 
ATOM   2156 C  CA  . PRO A 1 273 ? 45.207 -9.482  36.721 1.00 55.93  ? 712  PRO A CA  1 
ATOM   2157 C  C   . PRO A 1 273 ? 45.637 -10.845 36.214 1.00 59.20  ? 712  PRO A C   1 
ATOM   2158 O  O   . PRO A 1 273 ? 45.247 -11.256 35.109 1.00 59.39  ? 712  PRO A O   1 
ATOM   2159 C  CB  . PRO A 1 273 ? 44.013 -9.603  37.678 1.00 55.92  ? 712  PRO A CB  1 
ATOM   2160 C  CG  . PRO A 1 273 ? 42.833 -9.532  36.782 1.00 54.20  ? 712  PRO A CG  1 
ATOM   2161 C  CD  . PRO A 1 273 ? 43.207 -8.545  35.702 1.00 54.39  ? 712  PRO A CD  1 
ATOM   2162 N  N   . PRO A 1 274 ? 46.439 -11.580 36.985 1.00 60.09  ? 713  PRO A N   1 
ATOM   2163 C  CA  . PRO A 1 274 ? 46.756 -12.957 36.591 1.00 60.00  ? 713  PRO A CA  1 
ATOM   2164 C  C   . PRO A 1 274 ? 45.494 -13.803 36.587 1.00 60.87  ? 713  PRO A C   1 
ATOM   2165 O  O   . PRO A 1 274 ? 44.583 -13.597 37.392 1.00 60.94  ? 713  PRO A O   1 
ATOM   2166 C  CB  . PRO A 1 274 ? 47.748 -13.419 37.665 1.00 55.49  ? 713  PRO A CB  1 
ATOM   2167 C  CG  . PRO A 1 274 ? 47.488 -12.529 38.834 1.00 55.50  ? 713  PRO A CG  1 
ATOM   2168 C  CD  . PRO A 1 274 ? 47.075 -11.205 38.260 1.00 55.57  ? 713  PRO A CD  1 
ATOM   2169 N  N   . ARG A 1 275 ? 45.429 -14.741 35.648 1.00 64.92  ? 714  ARG A N   1 
ATOM   2170 C  CA  . ARG A 1 275 ? 44.265 -15.610 35.565 1.00 66.79  ? 714  ARG A CA  1 
ATOM   2171 C  C   . ARG A 1 275 ? 44.141 -16.411 36.859 1.00 69.97  ? 714  ARG A C   1 
ATOM   2172 O  O   . ARG A 1 275 ? 45.138 -16.971 37.339 1.00 71.70  ? 714  ARG A O   1 
ATOM   2173 C  CB  . ARG A 1 275 ? 44.353 -16.541 34.351 1.00 72.36  ? 714  ARG A CB  1 
ATOM   2174 C  CG  . ARG A 1 275 ? 45.508 -17.537 34.364 1.00 76.16  ? 714  ARG A CG  1 
ATOM   2175 C  CD  . ARG A 1 275 ? 45.067 -18.909 33.849 1.00 76.92  ? 714  ARG A CD  1 
ATOM   2176 N  NE  . ARG A 1 275 ? 44.712 -19.829 34.932 1.00 80.44  ? 714  ARG A NE  1 
ATOM   2177 C  CZ  . ARG A 1 275 ? 45.585 -20.401 35.758 1.00 81.49  ? 714  ARG A CZ  1 
ATOM   2178 N  NH1 . ARG A 1 275 ? 46.885 -20.158 35.634 1.00 82.10  ? 714  ARG A NH1 1 
ATOM   2179 N  NH2 . ARG A 1 275 ? 45.158 -21.221 36.712 1.00 81.17  ? 714  ARG A NH2 1 
ATOM   2180 N  N   . PRO A 1 276 ? 42.966 -16.454 37.474 1.00 69.65  ? 715  PRO A N   1 
ATOM   2181 C  CA  . PRO A 1 276 ? 42.813 -17.149 38.750 1.00 68.96  ? 715  PRO A CA  1 
ATOM   2182 C  C   . PRO A 1 276 ? 42.584 -18.642 38.548 1.00 76.53  ? 715  PRO A C   1 
ATOM   2183 O  O   . PRO A 1 276 ? 42.329 -19.120 37.439 1.00 75.44  ? 715  PRO A O   1 
ATOM   2184 C  CB  . PRO A 1 276 ? 41.569 -16.485 39.348 1.00 67.44  ? 715  PRO A CB  1 
ATOM   2185 C  CG  . PRO A 1 276 ? 40.744 -16.160 38.153 1.00 66.65  ? 715  PRO A CG  1 
ATOM   2186 C  CD  . PRO A 1 276 ? 41.712 -15.810 37.045 1.00 66.68  ? 715  PRO A CD  1 
ATOM   2187 N  N   . SER A 1 277 ? 42.692 -19.370 39.652 1.00 78.50  ? 716  SER A N   1 
ATOM   2188 C  CA  . SER A 1 277 ? 42.363 -20.783 39.641 1.00 78.50  ? 716  SER A CA  1 
ATOM   2189 C  C   . SER A 1 277 ? 40.901 -20.961 39.248 1.00 79.65  ? 716  SER A C   1 
ATOM   2190 O  O   . SER A 1 277 ? 40.033 -20.240 39.762 1.00 80.17  ? 716  SER A O   1 
ATOM   2191 C  CB  . SER A 1 277 ? 42.617 -21.404 41.018 1.00 81.62  ? 716  SER A CB  1 
ATOM   2192 O  OG  . SER A 1 277 ? 42.534 -22.817 40.976 1.00 84.48  ? 716  SER A OG  1 
ATOM   2193 N  N   . PRO A 1 278 ? 40.588 -21.869 38.322 1.00 79.53  ? 717  PRO A N   1 
ATOM   2194 C  CA  . PRO A 1 278 ? 39.199 -22.315 38.201 1.00 77.99  ? 717  PRO A CA  1 
ATOM   2195 C  C   . PRO A 1 278 ? 38.781 -23.185 39.369 1.00 82.08  ? 717  PRO A C   1 
ATOM   2196 O  O   . PRO A 1 278 ? 37.580 -23.396 39.575 1.00 80.53  ? 717  PRO A O   1 
ATOM   2197 C  CB  . PRO A 1 278 ? 39.194 -23.092 36.880 1.00 79.69  ? 717  PRO A CB  1 
ATOM   2198 C  CG  . PRO A 1 278 ? 40.589 -23.622 36.773 1.00 80.36  ? 717  PRO A CG  1 
ATOM   2199 C  CD  . PRO A 1 278 ? 41.486 -22.579 37.391 1.00 79.77  ? 717  PRO A CD  1 
ATOM   2200 N  N   . SER A 1 279 ? 39.742 -23.677 40.154 1.00 84.11  ? 718  SER A N   1 
ATOM   2201 C  CA  . SER A 1 279 ? 39.497 -24.504 41.327 1.00 83.99  ? 718  SER A CA  1 
ATOM   2202 C  C   . SER A 1 279 ? 39.445 -23.686 42.615 1.00 83.69  ? 718  SER A C   1 
ATOM   2203 O  O   . SER A 1 279 ? 39.774 -24.209 43.692 1.00 82.27  ? 718  SER A O   1 
ATOM   2204 C  CB  . SER A 1 279 ? 40.582 -25.578 41.429 1.00 82.53  ? 718  SER A CB  1 
ATOM   2205 O  OG  . SER A 1 279 ? 40.963 -26.058 40.148 1.00 83.68  ? 718  SER A OG  1 
ATOM   2206 N  N   . SER A 1 280 ? 39.087 -22.406 42.534 1.00 82.14  ? 719  SER A N   1 
ATOM   2207 C  CA  . SER A 1 280 ? 39.112 -21.516 43.689 1.00 80.10  ? 719  SER A CA  1 
ATOM   2208 C  C   . SER A 1 280 ? 37.794 -20.768 43.783 1.00 78.78  ? 719  SER A C   1 
ATOM   2209 O  O   . SER A 1 280 ? 37.411 -20.056 42.849 1.00 77.03  ? 719  SER A O   1 
ATOM   2210 C  CB  . SER A 1 280 ? 40.276 -20.524 43.608 1.00 79.04  ? 719  SER A CB  1 
ATOM   2211 O  OG  . SER A 1 280 ? 40.657 -20.077 44.901 1.00 76.22  ? 719  SER A OG  1 
ATOM   2212 N  N   . THR A 1 281 ? 37.102 -20.937 44.910 1.00 79.60  ? 720  THR A N   1 
ATOM   2213 C  CA  . THR A 1 281 ? 35.940 -20.137 45.260 1.00 75.29  ? 720  THR A CA  1 
ATOM   2214 C  C   . THR A 1 281 ? 36.317 -18.915 46.096 1.00 72.02  ? 720  THR A C   1 
ATOM   2215 O  O   . THR A 1 281 ? 35.443 -18.310 46.729 1.00 70.38  ? 720  THR A O   1 
ATOM   2216 C  CB  . THR A 1 281 ? 34.920 -20.999 46.005 1.00 78.54  ? 720  THR A CB  1 
ATOM   2217 O  OG1 . THR A 1 281 ? 33.918 -20.159 46.593 1.00 78.64  ? 720  THR A OG1 1 
ATOM   2218 C  CG2 . THR A 1 281 ? 35.614 -21.804 47.102 1.00 76.35  ? 720  THR A CG2 1 
ATOM   2219 N  N   . SER A 1 282 ? 37.605 -18.550 46.112 1.00 72.08  ? 721  SER A N   1 
ATOM   2220 C  CA  . SER A 1 282 ? 38.117 -17.393 46.847 1.00 68.91  ? 721  SER A CA  1 
ATOM   2221 C  C   . SER A 1 282 ? 37.407 -16.109 46.425 1.00 67.12  ? 721  SER A C   1 
ATOM   2222 O  O   . SER A 1 282 ? 36.781 -16.069 45.366 1.00 67.56  ? 721  SER A O   1 
ATOM   2223 C  CB  . SER A 1 282 ? 39.630 -17.257 46.618 1.00 65.88  ? 721  SER A CB  1 
ATOM   2224 O  OG  . SER A 1 282 ? 39.956 -17.429 45.255 1.00 69.66  ? 721  SER A OG  1 
ATOM   2225 N  N   . MET A 1 283 ? 37.473 -15.063 47.257 1.00 64.11  ? 722  MET A N   1 
ATOM   2226 C  CA  . MET A 1 283 ? 36.944 -13.776 46.827 1.00 64.39  ? 722  MET A CA  1 
ATOM   2227 C  C   . MET A 1 283 ? 37.923 -13.085 45.888 1.00 62.11  ? 722  MET A C   1 
ATOM   2228 O  O   . MET A 1 283 ? 37.521 -12.252 45.071 1.00 61.03  ? 722  MET A O   1 
ATOM   2229 C  CB  . MET A 1 283 ? 36.641 -12.889 48.027 1.00 65.31  ? 722  MET A CB  1 
ATOM   2230 C  CG  . MET A 1 283 ? 35.636 -11.778 47.730 1.00 70.41  ? 722  MET A CG  1 
ATOM   2231 S  SD  . MET A 1 283 ? 35.371 -10.668 49.133 1.00 70.62  ? 722  MET A SD  1 
ATOM   2232 C  CE  . MET A 1 283 ? 37.026 -10.544 49.769 1.00 52.93  ? 722  MET A CE  1 
ATOM   2233 N  N   . GLY A 1 284 ? 39.210 -13.420 45.991 1.00 60.64  ? 723  GLY A N   1 
ATOM   2234 C  CA  . GLY A 1 284 ? 40.179 -12.918 45.031 1.00 57.74  ? 723  GLY A CA  1 
ATOM   2235 C  C   . GLY A 1 284 ? 39.931 -13.454 43.635 1.00 62.06  ? 723  GLY A C   1 
ATOM   2236 O  O   . GLY A 1 284 ? 39.894 -12.692 42.668 1.00 60.02  ? 723  GLY A O   1 
ATOM   2237 N  N   . SER A 1 285 ? 39.767 -14.776 43.509 1.00 63.69  ? 724  SER A N   1 
ATOM   2238 C  CA  . SER A 1 285 ? 39.544 -15.368 42.191 1.00 63.40  ? 724  SER A CA  1 
ATOM   2239 C  C   . SER A 1 285 ? 38.266 -14.841 41.545 1.00 62.77  ? 724  SER A C   1 
ATOM   2240 O  O   . SER A 1 285 ? 38.278 -14.462 40.364 1.00 62.28  ? 724  SER A O   1 
ATOM   2241 C  CB  . SER A 1 285 ? 39.498 -16.893 42.302 1.00 70.80  ? 724  SER A CB  1 
ATOM   2242 O  OG  . SER A 1 285 ? 40.629 -17.400 42.985 1.00 71.94  ? 724  SER A OG  1 
ATOM   2243 N  N   . GLN A 1 286 ? 37.165 -14.792 42.310 1.00 61.74  ? 725  GLN A N   1 
ATOM   2244 C  CA  . GLN A 1 286 ? 35.905 -14.292 41.768 1.00 62.53  ? 725  GLN A CA  1 
ATOM   2245 C  C   . GLN A 1 286 ? 36.067 -12.890 41.207 1.00 58.75  ? 725  GLN A C   1 
ATOM   2246 O  O   . GLN A 1 286 ? 35.555 -12.582 40.126 1.00 59.82  ? 725  GLN A O   1 
ATOM   2247 C  CB  . GLN A 1 286 ? 34.823 -14.298 42.841 1.00 65.11  ? 725  GLN A CB  1 
ATOM   2248 C  CG  . GLN A 1 286 ? 34.416 -15.674 43.305 1.00 67.91  ? 725  GLN A CG  1 
ATOM   2249 C  CD  . GLN A 1 286 ? 33.671 -15.644 44.620 1.00 71.10  ? 725  GLN A CD  1 
ATOM   2250 O  OE1 . GLN A 1 286 ? 33.992 -16.392 45.542 1.00 71.48  ? 725  GLN A OE1 1 
ATOM   2251 N  NE2 . GLN A 1 286 ? 32.675 -14.769 44.719 1.00 70.12  ? 725  GLN A NE2 1 
ATOM   2252 N  N   . ARG A 1 287 ? 36.789 -12.027 41.924 1.00 57.76  ? 726  ARG A N   1 
ATOM   2253 C  CA  . ARG A 1 287 ? 37.000 -10.667 41.440 1.00 58.33  ? 726  ARG A CA  1 
ATOM   2254 C  C   . ARG A 1 287 ? 37.880 -10.664 40.196 1.00 58.16  ? 726  ARG A C   1 
ATOM   2255 O  O   . ARG A 1 287 ? 37.563 -10.005 39.198 1.00 57.47  ? 726  ARG A O   1 
ATOM   2256 C  CB  . ARG A 1 287 ? 37.613 -9.802  42.543 1.00 54.56  ? 726  ARG A CB  1 
ATOM   2257 C  CG  . ARG A 1 287 ? 37.806 -8.347  42.156 1.00 54.62  ? 726  ARG A CG  1 
ATOM   2258 C  CD  . ARG A 1 287 ? 36.652 -7.480  42.624 1.00 55.08  ? 726  ARG A CD  1 
ATOM   2259 N  NE  . ARG A 1 287 ? 35.377 -7.904  42.052 1.00 57.24  ? 726  ARG A NE  1 
ATOM   2260 C  CZ  . ARG A 1 287 ? 34.949 -7.559  40.842 1.00 57.53  ? 726  ARG A CZ  1 
ATOM   2261 N  NH1 . ARG A 1 287 ? 35.696 -6.780  40.072 1.00 56.52  ? 726  ARG A NH1 1 
ATOM   2262 N  NH2 . ARG A 1 287 ? 33.774 -7.990  40.402 1.00 57.30  ? 726  ARG A NH2 1 
ATOM   2263 N  N   . ARG A 1 288 ? 38.989 -11.405 40.235 1.00 57.39  ? 727  ARG A N   1 
ATOM   2264 C  CA  . ARG A 1 288 ? 39.839 -11.504 39.056 1.00 58.12  ? 727  ARG A CA  1 
ATOM   2265 C  C   . ARG A 1 288 ? 39.113 -12.189 37.907 1.00 59.26  ? 727  ARG A C   1 
ATOM   2266 O  O   . ARG A 1 288 ? 39.340 -11.851 36.739 1.00 57.83  ? 727  ARG A O   1 
ATOM   2267 C  CB  . ARG A 1 288 ? 41.133 -12.238 39.406 1.00 55.00  ? 727  ARG A CB  1 
ATOM   2268 C  CG  . ARG A 1 288 ? 41.954 -11.526 40.463 1.00 53.32  ? 727  ARG A CG  1 
ATOM   2269 C  CD  . ARG A 1 288 ? 43.353 -12.104 40.583 1.00 55.31  ? 727  ARG A CD  1 
ATOM   2270 N  NE  . ARG A 1 288 ? 43.367 -13.364 41.321 1.00 60.13  ? 727  ARG A NE  1 
ATOM   2271 C  CZ  . ARG A 1 288 ? 43.326 -13.461 42.647 1.00 58.73  ? 727  ARG A CZ  1 
ATOM   2272 N  NH1 . ARG A 1 288 ? 43.269 -12.366 43.398 1.00 56.84  ? 727  ARG A NH1 1 
ATOM   2273 N  NH2 . ARG A 1 288 ? 43.342 -14.654 43.225 1.00 57.97  ? 727  ARG A NH2 1 
ATOM   2274 N  N   . ARG A 1 289 ? 38.224 -13.137 38.217 1.00 59.51  ? 728  ARG A N   1 
ATOM   2275 C  CA  . ARG A 1 289 ? 37.414 -13.766 37.179 1.00 59.38  ? 728  ARG A CA  1 
ATOM   2276 C  C   . ARG A 1 289 ? 36.536 -12.739 36.473 1.00 58.06  ? 728  ARG A C   1 
ATOM   2277 O  O   . ARG A 1 289 ? 36.442 -12.733 35.242 1.00 58.28  ? 728  ARG A O   1 
ATOM   2278 C  CB  . ARG A 1 289 ? 36.556 -14.874 37.791 1.00 61.09  ? 728  ARG A CB  1 
ATOM   2279 C  CG  . ARG A 1 289 ? 36.577 -16.193 37.044 1.00 64.55  ? 728  ARG A CG  1 
ATOM   2280 C  CD  . ARG A 1 289 ? 36.049 -17.329 37.921 1.00 68.27  ? 728  ARG A CD  1 
ATOM   2281 N  NE  . ARG A 1 289 ? 37.117 -18.068 38.592 1.00 68.54  ? 728  ARG A NE  1 
ATOM   2282 C  CZ  . ARG A 1 289 ? 37.075 -18.461 39.863 1.00 68.81  ? 728  ARG A CZ  1 
ATOM   2283 N  NH1 . ARG A 1 289 ? 36.021 -18.182 40.618 1.00 66.14  ? 728  ARG A NH1 1 
ATOM   2284 N  NH2 . ARG A 1 289 ? 38.093 -19.133 40.382 1.00 71.79  ? 728  ARG A NH2 1 
ATOM   2285 N  N   . GLU A 1 290 ? 35.893 -11.854 37.240 1.00 59.56  ? 729  GLU A N   1 
ATOM   2286 C  CA  . GLU A 1 290 ? 35.021 -10.847 36.646 1.00 58.64  ? 729  GLU A CA  1 
ATOM   2287 C  C   . GLU A 1 290 ? 35.818 -9.732  35.982 1.00 59.09  ? 729  GLU A C   1 
ATOM   2288 O  O   . GLU A 1 290 ? 35.377 -9.177  34.968 1.00 57.31  ? 729  GLU A O   1 
ATOM   2289 C  CB  . GLU A 1 290 ? 34.089 -10.269 37.708 1.00 58.22  ? 729  GLU A CB  1 
ATOM   2290 C  CG  . GLU A 1 290 ? 33.026 -11.238 38.194 1.00 58.89  ? 729  GLU A CG  1 
ATOM   2291 C  CD  . GLU A 1 290 ? 32.045 -11.620 37.102 1.00 62.28  ? 729  GLU A CD  1 
ATOM   2292 O  OE1 . GLU A 1 290 ? 31.703 -10.749 36.272 1.00 64.31  ? 729  GLU A OE1 1 
ATOM   2293 O  OE2 . GLU A 1 290 ? 31.617 -12.793 37.072 1.00 62.04  ? 729  GLU A OE2 1 
ATOM   2294 N  N   . ALA A 1 291 ? 36.984 -9.392  36.537 1.00 57.77  ? 730  ALA A N   1 
ATOM   2295 C  CA  . ALA A 1 291 ? 37.796 -8.323  35.964 1.00 57.36  ? 730  ALA A CA  1 
ATOM   2296 C  C   . ALA A 1 291 ? 38.385 -8.733  34.620 1.00 59.38  ? 730  ALA A C   1 
ATOM   2297 O  O   . ALA A 1 291 ? 38.471 -7.914  33.697 1.00 57.41  ? 730  ALA A O   1 
ATOM   2298 C  CB  . ALA A 1 291 ? 38.904 -7.928  36.940 1.00 56.76  ? 730  ALA A CB  1 
ATOM   2299 N  N   . LEU A 1 292 ? 38.786 -10.000 34.488 1.00 60.47  ? 731  LEU A N   1 
ATOM   2300 C  CA  . LEU A 1 292 ? 39.393 -10.462 33.246 1.00 58.75  ? 731  LEU A CA  1 
ATOM   2301 C  C   . LEU A 1 292 ? 38.399 -10.514 32.092 1.00 59.05  ? 731  LEU A C   1 
ATOM   2302 O  O   . LEU A 1 292 ? 38.822 -10.569 30.933 1.00 63.08  ? 731  LEU A O   1 
ATOM   2303 C  CB  . LEU A 1 292 ? 40.038 -11.831 33.455 1.00 56.57  ? 731  LEU A CB  1 
ATOM   2304 C  CG  . LEU A 1 292 ? 41.400 -11.776 34.152 1.00 57.92  ? 731  LEU A CG  1 
ATOM   2305 C  CD1 . LEU A 1 292 ? 41.766 -13.126 34.726 1.00 59.83  ? 731  LEU A CD1 1 
ATOM   2306 C  CD2 . LEU A 1 292 ? 42.485 -11.285 33.203 1.00 54.79  ? 731  LEU A CD2 1 
ATOM   2307 N  N   . LYS A 1 293 ? 37.095 -10.486 32.375 1.00 60.06  ? 732  LYS A N   1 
ATOM   2308 C  CA  . LYS A 1 293 ? 36.115 -10.366 31.301 1.00 61.29  ? 732  LYS A CA  1 
ATOM   2309 C  C   . LYS A 1 293 ? 36.184 -9.009  30.613 1.00 60.47  ? 732  LYS A C   1 
ATOM   2310 O  O   . LYS A 1 293 ? 35.684 -8.870  29.492 1.00 65.67  ? 732  LYS A O   1 
ATOM   2311 C  CB  . LYS A 1 293 ? 34.700 -10.613 31.829 1.00 59.75  ? 732  LYS A CB  1 
ATOM   2312 C  CG  . LYS A 1 293 ? 34.518 -11.954 32.513 1.00 59.72  ? 732  LYS A CG  1 
ATOM   2313 C  CD  . LYS A 1 293 ? 33.259 -11.967 33.372 1.00 64.42  ? 732  LYS A CD  1 
ATOM   2314 C  CE  . LYS A 1 293 ? 32.798 -13.390 33.683 1.00 63.74  ? 732  LYS A CE  1 
ATOM   2315 N  NZ  . LYS A 1 293 ? 31.311 -13.476 33.783 1.00 59.51  ? 732  LYS A NZ  1 
ATOM   2316 N  N   . LEU A 1 294 ? 36.798 -8.013  31.246 1.00 59.80  ? 733  LEU A N   1 
ATOM   2317 C  CA  . LEU A 1 294 ? 36.951 -6.688  30.661 1.00 60.73  ? 733  LEU A CA  1 
ATOM   2318 C  C   . LEU A 1 294 ? 38.197 -6.564  29.791 1.00 60.33  ? 733  LEU A C   1 
ATOM   2319 O  O   . LEU A 1 294 ? 38.514 -5.460  29.338 1.00 59.95  ? 733  LEU A O   1 
ATOM   2320 C  CB  . LEU A 1 294 ? 36.984 -5.631  31.766 1.00 59.53  ? 733  LEU A CB  1 
ATOM   2321 C  CG  . LEU A 1 294 ? 35.919 -5.772  32.855 1.00 57.96  ? 733  LEU A CG  1 
ATOM   2322 C  CD1 . LEU A 1 294 ? 36.168 -4.792  33.993 1.00 52.98  ? 733  LEU A CD1 1 
ATOM   2323 C  CD2 . LEU A 1 294 ? 34.529 -5.576  32.264 1.00 55.23  ? 733  LEU A CD2 1 
ATOM   2324 N  N   . PHE A 1 295 ? 38.908 -7.661  29.556 1.00 59.97  ? 734  PHE A N   1 
ATOM   2325 C  CA  . PHE A 1 295 ? 40.135 -7.648  28.775 1.00 60.70  ? 734  PHE A CA  1 
ATOM   2326 C  C   . PHE A 1 295 ? 40.033 -8.661  27.646 1.00 62.69  ? 734  PHE A C   1 
ATOM   2327 O  O   . PHE A 1 295 ? 39.512 -9.765  27.834 1.00 61.99  ? 734  PHE A O   1 
ATOM   2328 C  CB  . PHE A 1 295 ? 41.365 -7.974  29.645 1.00 60.25  ? 734  PHE A CB  1 
ATOM   2329 C  CG  . PHE A 1 295 ? 41.651 -6.954  30.711 1.00 58.68  ? 734  PHE A CG  1 
ATOM   2330 C  CD1 . PHE A 1 295 ? 42.669 -6.029  30.546 1.00 59.16  ? 734  PHE A CD1 1 
ATOM   2331 C  CD2 . PHE A 1 295 ? 40.914 -6.928  31.883 1.00 56.68  ? 734  PHE A CD2 1 
ATOM   2332 C  CE1 . PHE A 1 295 ? 42.939 -5.092  31.527 1.00 57.17  ? 734  PHE A CE1 1 
ATOM   2333 C  CE2 . PHE A 1 295 ? 41.178 -5.991  32.865 1.00 56.49  ? 734  PHE A CE2 1 
ATOM   2334 C  CZ  . PHE A 1 295 ? 42.190 -5.073  32.686 1.00 55.53  ? 734  PHE A CZ  1 
ATOM   2335 N  N   . ARG A 1 296 ? 40.528 -8.276  26.471 1.00 64.09  ? 735  ARG A N   1 
ATOM   2336 C  CA  . ARG A 1 296 ? 40.723 -9.188  25.348 1.00 62.28  ? 735  ARG A CA  1 
ATOM   2337 C  C   . ARG A 1 296 ? 42.197 -9.138  24.973 1.00 61.10  ? 735  ARG A C   1 
ATOM   2338 O  O   . ARG A 1 296 ? 42.682 -8.109  24.492 1.00 63.61  ? 735  ARG A O   1 
ATOM   2339 C  CB  . ARG A 1 296 ? 39.842 -8.816  24.156 1.00 63.70  ? 735  ARG A CB  1 
ATOM   2340 C  CG  . ARG A 1 296 ? 38.351 -8.948  24.410 1.00 66.45  ? 735  ARG A CG  1 
ATOM   2341 C  CD  . ARG A 1 296 ? 37.853 -10.365 24.161 1.00 69.23  ? 735  ARG A CD  1 
ATOM   2342 N  NE  . ARG A 1 296 ? 36.539 -10.612 24.756 1.00 71.31  ? 735  ARG A NE  1 
ATOM   2343 C  CZ  . ARG A 1 296 ? 36.289 -10.644 26.064 1.00 71.23  ? 735  ARG A CZ  1 
ATOM   2344 N  NH1 . ARG A 1 296 ? 37.263 -10.449 26.945 1.00 67.88  ? 735  ARG A NH1 1 
ATOM   2345 N  NH2 . ARG A 1 296 ? 35.058 -10.878 26.498 1.00 72.96  ? 735  ARG A NH2 1 
ATOM   2346 N  N   . ASP A 1 297 ? 42.904 -10.243 25.214 1.00 64.41  ? 736  ASP A N   1 
ATOM   2347 C  CA  . ASP A 1 297 ? 44.306 -10.413 24.828 1.00 63.53  ? 736  ASP A CA  1 
ATOM   2348 C  C   . ASP A 1 297 ? 45.195 -9.340  25.466 1.00 63.24  ? 736  ASP A C   1 
ATOM   2349 O  O   . ASP A 1 297 ? 45.906 -8.589  24.792 1.00 60.81  ? 736  ASP A O   1 
ATOM   2350 C  CB  . ASP A 1 297 ? 44.451 -10.430 23.300 1.00 62.25  ? 736  ASP A CB  1 
ATOM   2351 C  CG  . ASP A 1 297 ? 43.651 -11.555 22.647 1.00 63.65  ? 736  ASP A CG  1 
ATOM   2352 O  OD1 . ASP A 1 297 ? 43.817 -12.732 23.042 1.00 61.40  ? 736  ASP A OD1 1 
ATOM   2353 O  OD2 . ASP A 1 297 ? 42.851 -11.256 21.736 1.00 64.94  ? 736  ASP A OD2 1 
ATOM   2354 N  N   . GLY A 1 298 ? 45.139 -9.283  26.797 1.00 61.74  ? 737  GLY A N   1 
ATOM   2355 C  CA  . GLY A 1 298 ? 46.010 -8.424  27.570 1.00 58.55  ? 737  GLY A CA  1 
ATOM   2356 C  C   . GLY A 1 298 ? 45.757 -6.941  27.439 1.00 59.45  ? 737  GLY A C   1 
ATOM   2357 O  O   . GLY A 1 298 ? 46.499 -6.152  28.033 1.00 58.79  ? 737  GLY A O   1 
ATOM   2358 N  N   . ARG A 1 299 ? 44.745 -6.531  26.681 1.00 60.83  ? 738  ARG A N   1 
ATOM   2359 C  CA  . ARG A 1 299 ? 44.384 -5.129  26.537 1.00 61.97  ? 738  ARG A CA  1 
ATOM   2360 C  C   . ARG A 1 299 ? 42.999 -4.911  27.125 1.00 62.25  ? 738  ARG A C   1 
ATOM   2361 O  O   . ARG A 1 299 ? 42.122 -5.774  27.003 1.00 62.25  ? 738  ARG A O   1 
ATOM   2362 C  CB  . ARG A 1 299 ? 44.411 -4.697  25.064 1.00 63.13  ? 738  ARG A CB  1 
ATOM   2363 C  CG  . ARG A 1 299 ? 44.028 -3.237  24.821 1.00 64.63  ? 738  ARG A CG  1 
ATOM   2364 C  CD  . ARG A 1 299 ? 43.831 -2.951  23.338 1.00 64.63  ? 738  ARG A CD  1 
ATOM   2365 N  NE  . ARG A 1 299 ? 42.758 -3.766  22.774 1.00 68.74  ? 738  ARG A NE  1 
ATOM   2366 C  CZ  . ARG A 1 299 ? 41.543 -3.311  22.482 1.00 69.42  ? 738  ARG A CZ  1 
ATOM   2367 N  NH1 . ARG A 1 299 ? 41.242 -2.036  22.693 1.00 66.71  ? 738  ARG A NH1 1 
ATOM   2368 N  NH2 . ARG A 1 299 ? 40.630 -4.132  21.976 1.00 68.11  ? 738  ARG A NH2 1 
ATOM   2369 N  N   . LEU A 1 300 ? 42.813 -3.769  27.786 1.00 59.22  ? 739  LEU A N   1 
ATOM   2370 C  CA  . LEU A 1 300 ? 41.488 -3.401  28.264 1.00 59.32  ? 739  LEU A CA  1 
ATOM   2371 C  C   . LEU A 1 300 ? 40.521 -3.350  27.090 1.00 61.75  ? 739  LEU A C   1 
ATOM   2372 O  O   . LEU A 1 300 ? 40.767 -2.657  26.098 1.00 64.75  ? 739  LEU A O   1 
ATOM   2373 C  CB  . LEU A 1 300 ? 41.534 -2.050  28.981 1.00 60.30  ? 739  LEU A CB  1 
ATOM   2374 C  CG  . LEU A 1 300 ? 40.237 -1.579  29.645 1.00 58.32  ? 739  LEU A CG  1 
ATOM   2375 C  CD1 . LEU A 1 300 ? 39.935 -2.422  30.871 1.00 54.84  ? 739  LEU A CD1 1 
ATOM   2376 C  CD2 . LEU A 1 300 ? 40.302 -0.098  30.003 1.00 54.04  ? 739  LEU A CD2 1 
ATOM   2377 N  N   . ASN A 1 301 ? 39.423 -4.094  27.200 1.00 61.93  ? 740  ASN A N   1 
ATOM   2378 C  CA  . ASN A 1 301 ? 38.499 -4.255  26.084 1.00 64.33  ? 740  ASN A CA  1 
ATOM   2379 C  C   . ASN A 1 301 ? 37.612 -3.031  25.889 1.00 64.79  ? 740  ASN A C   1 
ATOM   2380 O  O   . ASN A 1 301 ? 36.387 -3.152  25.824 1.00 67.01  ? 740  ASN A O   1 
ATOM   2381 C  CB  . ASN A 1 301 ? 37.637 -5.504  26.292 1.00 65.46  ? 740  ASN A CB  1 
ATOM   2382 C  CG  . ASN A 1 301 ? 36.989 -5.985  25.009 1.00 70.02  ? 740  ASN A CG  1 
ATOM   2383 O  OD1 . ASN A 1 301 ? 37.514 -5.767  23.913 1.00 70.55  ? 740  ASN A OD1 1 
ATOM   2384 N  ND2 . ASN A 1 301 ? 35.854 -6.663  25.138 1.00 70.16  ? 740  ASN A ND2 1 
ATOM   2385 N  N   . TRP A 1 302 ? 38.212 -1.857  25.793 1.00 64.30  ? 741  TRP A N   1 
ATOM   2386 C  CA  . TRP A 1 302 ? 37.453 -0.662  25.475 1.00 64.68  ? 741  TRP A CA  1 
ATOM   2387 C  C   . TRP A 1 302 ? 37.879 -0.129  24.112 1.00 64.95  ? 741  TRP A C   1 
ATOM   2388 O  O   . TRP A 1 302 ? 39.077 -0.108  23.810 1.00 63.54  ? 741  TRP A O   1 
ATOM   2389 C  CB  . TRP A 1 302 ? 37.656 0.427   26.541 1.00 63.86  ? 741  TRP A CB  1 
ATOM   2390 C  CG  . TRP A 1 302 ? 36.707 1.575   26.409 1.00 62.61  ? 741  TRP A CG  1 
ATOM   2391 C  CD1 . TRP A 1 302 ? 35.506 1.725   27.038 1.00 60.68  ? 741  TRP A CD1 1 
ATOM   2392 C  CD2 . TRP A 1 302 ? 36.873 2.731   25.579 1.00 63.38  ? 741  TRP A CD2 1 
ATOM   2393 N  NE1 . TRP A 1 302 ? 34.916 2.905   26.655 1.00 62.76  ? 741  TRP A NE1 1 
ATOM   2394 C  CE2 . TRP A 1 302 ? 35.735 3.541   25.759 1.00 63.68  ? 741  TRP A CE2 1 
ATOM   2395 C  CE3 . TRP A 1 302 ? 37.875 3.159   24.702 1.00 61.11  ? 741  TRP A CE3 1 
ATOM   2396 C  CZ2 . TRP A 1 302 ? 35.571 4.753   25.095 1.00 65.74  ? 741  TRP A CZ2 1 
ATOM   2397 C  CZ3 . TRP A 1 302 ? 37.710 4.363   24.045 1.00 63.51  ? 741  TRP A CZ3 1 
ATOM   2398 C  CH2 . TRP A 1 302 ? 36.568 5.147   24.245 1.00 64.87  ? 741  TRP A CH2 1 
ATOM   2399 N  N   . PRO A 1 303 ? 36.936 0.323   23.266 1.00 66.05  ? 742  PRO A N   1 
ATOM   2400 C  CA  . PRO A 1 303 ? 35.496 0.446   23.511 1.00 66.83  ? 742  PRO A CA  1 
ATOM   2401 C  C   . PRO A 1 303 ? 34.651 -0.731  23.026 1.00 69.01  ? 742  PRO A C   1 
ATOM   2402 O  O   . PRO A 1 303 ? 33.428 -0.678  23.148 1.00 71.25  ? 742  PRO A O   1 
ATOM   2403 C  CB  . PRO A 1 303 ? 35.139 1.705   22.726 1.00 66.53  ? 742  PRO A CB  1 
ATOM   2404 C  CG  . PRO A 1 303 ? 36.038 1.634   21.532 1.00 66.19  ? 742  PRO A CG  1 
ATOM   2405 C  CD  . PRO A 1 303 ? 37.311 0.931   21.977 1.00 65.13  ? 742  PRO A CD  1 
ATOM   2406 N  N   . GLU A 1 304 ? 35.289 -1.773  22.488 1.00 69.50  ? 743  GLU A N   1 
ATOM   2407 C  CA  . GLU A 1 304 ? 34.530 -2.890  21.933 1.00 71.78  ? 743  GLU A CA  1 
ATOM   2408 C  C   . GLU A 1 304 ? 33.763 -3.648  23.010 1.00 74.48  ? 743  GLU A C   1 
ATOM   2409 O  O   . GLU A 1 304 ? 32.716 -4.238  22.720 1.00 75.10  ? 743  GLU A O   1 
ATOM   2410 C  CB  . GLU A 1 304 ? 35.458 -3.844  21.180 1.00 70.33  ? 743  GLU A CB  1 
ATOM   2411 C  CG  . GLU A 1 304 ? 36.345 -3.169  20.146 1.00 72.59  ? 743  GLU A CG  1 
ATOM   2412 C  CD  . GLU A 1 304 ? 37.620 -2.621  20.751 1.00 73.40  ? 743  GLU A CD  1 
ATOM   2413 O  OE1 . GLU A 1 304 ? 37.866 -2.885  21.946 1.00 71.87  ? 743  GLU A OE1 1 
ATOM   2414 O  OE2 . GLU A 1 304 ? 38.371 -1.923  20.036 1.00 74.35  ? 743  GLU A OE2 1 
ATOM   2415 N  N   . GLY A 1 305 ? 34.257 -3.640  24.250 1.00 73.62  ? 744  GLY A N   1 
ATOM   2416 C  CA  . GLY A 1 305 ? 33.629 -4.374  25.336 1.00 74.39  ? 744  GLY A CA  1 
ATOM   2417 C  C   . GLY A 1 305 ? 32.358 -3.766  25.893 1.00 75.37  ? 744  GLY A C   1 
ATOM   2418 O  O   . GLY A 1 305 ? 31.636 -4.458  26.620 1.00 73.72  ? 744  GLY A O   1 
ATOM   2419 N  N   . ILE A 1 306 ? 32.069 -2.499  25.575 1.00 74.13  ? 745  ILE A N   1 
ATOM   2420 C  CA  . ILE A 1 306 ? 30.799 -1.903  25.984 1.00 74.08  ? 745  ILE A CA  1 
ATOM   2421 C  C   . ILE A 1 306 ? 29.636 -2.612  25.303 1.00 75.35  ? 745  ILE A C   1 
ATOM   2422 O  O   . ILE A 1 306 ? 28.520 -2.646  25.835 1.00 75.16  ? 745  ILE A O   1 
ATOM   2423 C  CB  . ILE A 1 306 ? 30.797 -0.387  25.695 1.00 72.62  ? 745  ILE A CB  1 
ATOM   2424 C  CG1 . ILE A 1 306 ? 32.027 0.282   26.315 1.00 69.19  ? 745  ILE A CG1 1 
ATOM   2425 C  CG2 . ILE A 1 306 ? 29.523 0.274   26.225 1.00 70.75  ? 745  ILE A CG2 1 
ATOM   2426 C  CD1 . ILE A 1 306 ? 31.842 0.686   27.764 1.00 67.24  ? 745  ILE A CD1 1 
ATOM   2427 N  N   . ASP A 1 307 ? 29.875 -3.197  24.132 1.00 79.74  ? 746  ASP A N   1 
ATOM   2428 C  CA  . ASP A 1 307 ? 28.874 -4.021  23.456 1.00 81.21  ? 746  ASP A CA  1 
ATOM   2429 C  C   . ASP A 1 307 ? 29.507 -5.286  22.872 1.00 77.14  ? 746  ASP A C   1 
ATOM   2430 O  O   . ASP A 1 307 ? 29.217 -5.679  21.742 1.00 76.63  ? 746  ASP A O   1 
ATOM   2431 C  CB  . ASP A 1 307 ? 28.175 -3.218  22.359 1.00 80.32  ? 746  ASP A CB  1 
ATOM   2432 C  CG  . ASP A 1 307 ? 26.808 -2.723  22.784 1.00 81.88  ? 746  ASP A CG  1 
ATOM   2433 O  OD1 . ASP A 1 307 ? 26.057 -2.214  21.927 1.00 81.77  ? 746  ASP A OD1 1 
ATOM   2434 O  OD2 . ASP A 1 307 ? 26.482 -2.847  23.981 1.00 82.17  ? 746  ASP A OD2 1 
ATOM   2435 N  N   . LEU A 1 314 ? 25.238 2.494   19.822 1.00 78.32  ? 753  LEU A N   1 
ATOM   2436 C  CA  . LEU A 1 314 ? 24.355 3.073   20.833 1.00 82.11  ? 753  LEU A CA  1 
ATOM   2437 C  C   . LEU A 1 314 ? 25.154 3.489   22.064 1.00 84.00  ? 753  LEU A C   1 
ATOM   2438 O  O   . LEU A 1 314 ? 25.467 4.665   22.251 1.00 80.04  ? 753  LEU A O   1 
ATOM   2439 C  CB  . LEU A 1 314 ? 23.254 2.076   21.225 1.00 87.00  ? 753  LEU A CB  1 
ATOM   2440 C  CG  . LEU A 1 314 ? 22.148 2.487   22.214 1.00 89.35  ? 753  LEU A CG  1 
ATOM   2441 C  CD1 . LEU A 1 314 ? 22.499 2.223   23.670 1.00 89.63  ? 753  LEU A CD1 1 
ATOM   2442 C  CD2 . LEU A 1 314 ? 21.769 3.954   22.034 1.00 85.82  ? 753  LEU A CD2 1 
ATOM   2443 N  N   . ALA A 1 315 ? 25.473 2.503   22.905 1.00 85.58  ? 754  ALA A N   1 
ATOM   2444 C  CA  . ALA A 1 315 ? 26.175 2.775   24.153 1.00 80.28  ? 754  ALA A CA  1 
ATOM   2445 C  C   . ALA A 1 315 ? 27.668 2.937   23.916 1.00 79.13  ? 754  ALA A C   1 
ATOM   2446 O  O   . ALA A 1 315 ? 28.307 3.796   24.534 1.00 79.21  ? 754  ALA A O   1 
ATOM   2447 C  CB  . ALA A 1 315 ? 25.907 1.659   25.160 1.00 81.61  ? 754  ALA A CB  1 
ATOM   2448 N  N   . ARG A 1 316 ? 28.236 2.122   23.023 1.00 78.26  ? 755  ARG A N   1 
ATOM   2449 C  CA  . ARG A 1 316 ? 29.629 2.301   22.629 1.00 77.70  ? 755  ARG A CA  1 
ATOM   2450 C  C   . ARG A 1 316 ? 29.877 3.697   22.069 1.00 78.99  ? 755  ARG A C   1 
ATOM   2451 O  O   . ARG A 1 316 ? 31.006 4.198   22.124 1.00 79.40  ? 755  ARG A O   1 
ATOM   2452 C  CB  . ARG A 1 316 ? 30.017 1.230   21.608 1.00 76.32  ? 755  ARG A CB  1 
ATOM   2453 C  CG  . ARG A 1 316 ? 31.478 1.239   21.192 1.00 73.12  ? 755  ARG A CG  1 
ATOM   2454 C  CD  . ARG A 1 316 ? 31.682 0.415   19.929 1.00 73.52  ? 755  ARG A CD  1 
ATOM   2455 N  NE  . ARG A 1 316 ? 31.650 -1.019  20.206 1.00 76.81  ? 755  ARG A NE  1 
ATOM   2456 C  CZ  . ARG A 1 316 ? 30.589 -1.799  20.022 1.00 77.83  ? 755  ARG A CZ  1 
ATOM   2457 N  NH1 . ARG A 1 316 ? 29.455 -1.293  19.556 1.00 78.49  ? 755  ARG A NH1 1 
ATOM   2458 N  NH2 . ARG A 1 316 ? 30.664 -3.092  20.306 1.00 75.71  ? 755  ARG A NH2 1 
ATOM   2459 N  N   . GLN A 1 317 ? 28.838 4.344   21.535 1.00 80.94  ? 756  GLN A N   1 
ATOM   2460 C  CA  . GLN A 1 317 ? 28.984 5.722   21.079 1.00 80.35  ? 756  GLN A CA  1 
ATOM   2461 C  C   . GLN A 1 317 ? 28.921 6.713   22.236 1.00 79.62  ? 756  GLN A C   1 
ATOM   2462 O  O   . GLN A 1 317 ? 29.608 7.742   22.202 1.00 78.05  ? 756  GLN A O   1 
ATOM   2463 C  CB  . GLN A 1 317 ? 27.912 6.052   20.037 1.00 82.29  ? 756  GLN A CB  1 
ATOM   2464 C  CG  . GLN A 1 317 ? 28.463 6.286   18.634 1.00 81.82  ? 756  GLN A CG  1 
ATOM   2465 C  CD  . GLN A 1 317 ? 27.505 7.062   17.749 1.00 83.08  ? 756  GLN A CD  1 
ATOM   2466 O  OE1 . GLN A 1 317 ? 26.304 7.122   18.018 1.00 84.28  ? 756  GLN A OE1 1 
ATOM   2467 N  NE2 . GLN A 1 317 ? 28.033 7.665   16.690 1.00 79.96  ? 756  GLN A NE2 1 
ATOM   2468 N  N   . LYS A 1 318 ? 28.117 6.423   23.263 1.00 79.91  ? 757  LYS A N   1 
ATOM   2469 C  CA  . LYS A 1 318 ? 28.055 7.306   24.424 1.00 78.10  ? 757  LYS A CA  1 
ATOM   2470 C  C   . LYS A 1 318 ? 29.303 7.168   25.287 1.00 76.32  ? 757  LYS A C   1 
ATOM   2471 O  O   . LYS A 1 318 ? 29.775 8.151   25.870 1.00 74.54  ? 757  LYS A O   1 
ATOM   2472 C  CB  . LYS A 1 318 ? 26.800 7.018   25.249 1.00 79.76  ? 757  LYS A CB  1 
ATOM   2473 C  CG  . LYS A 1 318 ? 25.494 7.168   24.492 1.00 80.37  ? 757  LYS A CG  1 
ATOM   2474 C  CD  . LYS A 1 318 ? 24.350 7.466   25.452 1.00 81.68  ? 757  LYS A CD  1 
ATOM   2475 C  CE  . LYS A 1 318 ? 23.013 6.987   24.908 1.00 81.37  ? 757  LYS A CE  1 
ATOM   2476 N  NZ  . LYS A 1 318 ? 22.742 7.516   23.543 1.00 79.38  ? 757  LYS A NZ  1 
ATOM   2477 N  N   . SER A 1 319 ? 29.846 5.953   25.391 1.00 74.75  ? 758  SER A N   1 
ATOM   2478 C  CA  . SER A 1 319 ? 31.084 5.766   26.137 1.00 71.66  ? 758  SER A CA  1 
ATOM   2479 C  C   . SER A 1 319 ? 32.270 6.412   25.425 1.00 71.75  ? 758  SER A C   1 
ATOM   2480 O  O   . SER A 1 319 ? 33.190 6.913   26.083 1.00 68.59  ? 758  SER A O   1 
ATOM   2481 C  CB  . SER A 1 319 ? 31.333 4.274   26.361 1.00 67.93  ? 758  SER A CB  1 
ATOM   2482 O  OG  . SER A 1 319 ? 32.585 4.051   26.986 1.00 64.53  ? 758  SER A OG  1 
ATOM   2483 N  N   . ILE A 1 320 ? 32.259 6.428   24.090 1.00 72.73  ? 759  ILE A N   1 
ATOM   2484 C  CA  . ILE A 1 320 ? 33.374 7.007   23.346 1.00 72.26  ? 759  ILE A CA  1 
ATOM   2485 C  C   . ILE A 1 320 ? 33.423 8.520   23.537 1.00 71.27  ? 759  ILE A C   1 
ATOM   2486 O  O   . ILE A 1 320 ? 34.502 9.102   23.703 1.00 69.55  ? 759  ILE A O   1 
ATOM   2487 C  CB  . ILE A 1 320 ? 33.284 6.611   21.860 1.00 71.65  ? 759  ILE A CB  1 
ATOM   2488 C  CG1 . ILE A 1 320 ? 33.964 5.255   21.629 1.00 71.76  ? 759  ILE A CG1 1 
ATOM   2489 C  CG2 . ILE A 1 320 ? 33.915 7.676   20.974 1.00 72.49  ? 759  ILE A CG2 1 
ATOM   2490 C  CD1 . ILE A 1 320 ? 33.801 4.700   20.220 1.00 66.58  ? 759  ILE A CD1 1 
ATOM   2491 N  N   . ARG A 1 321 ? 32.262 9.184   23.537 1.00 71.10  ? 760  ARG A N   1 
ATOM   2492 C  CA  . ARG A 1 321 ? 32.259 10.632  23.721 1.00 73.53  ? 760  ARG A CA  1 
ATOM   2493 C  C   . ARG A 1 321 ? 32.602 11.009  25.160 1.00 70.74  ? 760  ARG A C   1 
ATOM   2494 O  O   . ARG A 1 321 ? 33.330 11.980  25.396 1.00 67.07  ? 760  ARG A O   1 
ATOM   2495 C  CB  . ARG A 1 321 ? 30.907 11.222  23.309 1.00 74.88  ? 760  ARG A CB  1 
ATOM   2496 C  CG  . ARG A 1 321 ? 29.707 10.489  23.879 1.00 79.27  ? 760  ARG A CG  1 
ATOM   2497 C  CD  . ARG A 1 321 ? 28.388 10.957  23.274 1.00 83.81  ? 760  ARG A CD  1 
ATOM   2498 N  NE  . ARG A 1 321 ? 27.383 11.213  24.306 1.00 88.82  ? 760  ARG A NE  1 
ATOM   2499 C  CZ  . ARG A 1 321 ? 26.275 11.921  24.113 1.00 92.72  ? 760  ARG A CZ  1 
ATOM   2500 N  NH1 . ARG A 1 321 ? 26.022 12.446  22.922 1.00 92.23  ? 760  ARG A NH1 1 
ATOM   2501 N  NH2 . ARG A 1 321 ? 25.418 12.107  25.110 1.00 93.88  ? 760  ARG A NH2 1 
ATOM   2502 N  N   . ARG A 1 322 ? 32.097 10.244  26.134 1.00 71.37  ? 761  ARG A N   1 
ATOM   2503 C  CA  . ARG A 1 322 ? 32.408 10.516  27.536 1.00 69.85  ? 761  ARG A CA  1 
ATOM   2504 C  C   . ARG A 1 322 ? 33.898 10.361  27.816 1.00 67.19  ? 761  ARG A C   1 
ATOM   2505 O  O   . ARG A 1 322 ? 34.504 11.211  28.479 1.00 65.50  ? 761  ARG A O   1 
ATOM   2506 C  CB  . ARG A 1 322 ? 31.597 9.589   28.440 1.00 70.08  ? 761  ARG A CB  1 
ATOM   2507 C  CG  . ARG A 1 322 ? 31.748 9.855   29.926 1.00 67.58  ? 761  ARG A CG  1 
ATOM   2508 C  CD  . ARG A 1 322 ? 30.666 9.135   30.718 1.00 70.75  ? 761  ARG A CD  1 
ATOM   2509 N  NE  . ARG A 1 322 ? 30.237 7.897   30.065 1.00 73.82  ? 761  ARG A NE  1 
ATOM   2510 C  CZ  . ARG A 1 322 ? 29.035 7.698   29.523 1.00 74.71  ? 761  ARG A CZ  1 
ATOM   2511 N  NH1 . ARG A 1 322 ? 28.750 6.531   28.956 1.00 74.29  ? 761  ARG A NH1 1 
ATOM   2512 N  NH2 . ARG A 1 322 ? 28.121 8.660   29.541 1.00 74.11  ? 761  ARG A NH2 1 
ATOM   2513 N  N   . VAL A 1 323 ? 34.504 9.277   27.324 1.00 66.76  ? 762  VAL A N   1 
ATOM   2514 C  CA  . VAL A 1 323 ? 35.948 9.105   27.455 1.00 65.28  ? 762  VAL A CA  1 
ATOM   2515 C  C   . VAL A 1 323 ? 36.690 10.195  26.690 1.00 63.98  ? 762  VAL A C   1 
ATOM   2516 O  O   . VAL A 1 323 ? 37.746 10.661  27.132 1.00 63.31  ? 762  VAL A O   1 
ATOM   2517 C  CB  . VAL A 1 323 ? 36.359 7.692   26.992 1.00 62.94  ? 762  VAL A CB  1 
ATOM   2518 C  CG1 . VAL A 1 323 ? 37.873 7.561   26.899 1.00 60.41  ? 762  VAL A CG1 1 
ATOM   2519 C  CG2 . VAL A 1 323 ? 35.805 6.644   27.944 1.00 61.17  ? 762  VAL A CG2 1 
ATOM   2520 N  N   . ALA A 1 324 ? 36.148 10.631  25.549 1.00 65.93  ? 763  ALA A N   1 
ATOM   2521 C  CA  . ALA A 1 324 ? 36.801 11.680  24.770 1.00 66.92  ? 763  ALA A CA  1 
ATOM   2522 C  C   . ALA A 1 324 ? 36.840 13.004  25.523 1.00 64.11  ? 763  ALA A C   1 
ATOM   2523 O  O   . ALA A 1 324 ? 37.809 13.760  25.391 1.00 63.44  ? 763  ALA A O   1 
ATOM   2524 C  CB  . ALA A 1 324 ? 36.098 11.854  23.425 1.00 65.26  ? 763  ALA A CB  1 
ATOM   2525 N  N   . ARG A 1 325 ? 35.806 13.298  26.317 1.00 63.78  ? 764  ARG A N   1 
ATOM   2526 C  CA  . ARG A 1 325 ? 35.803 14.529  27.100 1.00 65.64  ? 764  ARG A CA  1 
ATOM   2527 C  C   . ARG A 1 325 ? 36.680 14.420  28.338 1.00 63.40  ? 764  ARG A C   1 
ATOM   2528 O  O   . ARG A 1 325 ? 37.042 15.451  28.916 1.00 63.66  ? 764  ARG A O   1 
ATOM   2529 C  CB  . ARG A 1 325 ? 34.380 14.917  27.497 1.00 68.43  ? 764  ARG A CB  1 
ATOM   2530 C  CG  . ARG A 1 325 ? 33.670 15.734  26.435 1.00 69.84  ? 764  ARG A CG  1 
ATOM   2531 C  CD  . ARG A 1 325 ? 32.385 16.368  26.953 1.00 76.27  ? 764  ARG A CD  1 
ATOM   2532 N  NE  . ARG A 1 325 ? 31.315 16.335  25.958 1.00 80.11  ? 764  ARG A NE  1 
ATOM   2533 C  CZ  . ARG A 1 325 ? 30.257 17.144  25.969 1.00 81.74  ? 764  ARG A CZ  1 
ATOM   2534 N  NH1 . ARG A 1 325 ? 30.127 18.049  26.929 1.00 79.06  ? 764  ARG A NH1 1 
ATOM   2535 N  NH2 . ARG A 1 325 ? 29.326 17.045  25.026 1.00 80.35  ? 764  ARG A NH2 1 
ATOM   2536 N  N   . MET A 1 326 ? 37.035 13.206  28.752 1.00 63.26  ? 765  MET A N   1 
ATOM   2537 C  CA  . MET A 1 326 ? 37.930 13.006  29.885 1.00 60.40  ? 765  MET A CA  1 
ATOM   2538 C  C   . MET A 1 326 ? 39.282 13.630  29.580 1.00 60.64  ? 765  MET A C   1 
ATOM   2539 O  O   . MET A 1 326 ? 39.934 13.230  28.603 1.00 60.69  ? 765  MET A O   1 
ATOM   2540 C  CB  . MET A 1 326 ? 38.094 11.521  30.185 1.00 60.74  ? 765  MET A CB  1 
ATOM   2541 C  CG  . MET A 1 326 ? 39.030 11.215  31.345 1.00 57.47  ? 765  MET A CG  1 
ATOM   2542 S  SD  . MET A 1 326 ? 38.355 11.744  32.932 1.00 58.20  ? 765  MET A SD  1 
ATOM   2543 C  CE  . MET A 1 326 ? 39.589 11.119  34.064 1.00 55.62  ? 765  MET A CE  1 
ATOM   2544 N  N   . PRO A 1 327 ? 39.737 14.598  30.366 1.00 60.87  ? 766  PRO A N   1 
ATOM   2545 C  CA  . PRO A 1 327 ? 40.998 15.270  30.053 1.00 59.88  ? 766  PRO A CA  1 
ATOM   2546 C  C   . PRO A 1 327 ? 42.212 14.448  30.451 1.00 59.74  ? 766  PRO A C   1 
ATOM   2547 O  O   . PRO A 1 327 ? 42.168 13.608  31.353 1.00 58.59  ? 766  PRO A O   1 
ATOM   2548 C  CB  . PRO A 1 327 ? 40.919 16.559  30.877 1.00 56.78  ? 766  PRO A CB  1 
ATOM   2549 C  CG  . PRO A 1 327 ? 40.083 16.184  32.048 1.00 58.16  ? 766  PRO A CG  1 
ATOM   2550 C  CD  . PRO A 1 327 ? 39.069 15.191  31.537 1.00 60.70  ? 766  PRO A CD  1 
ATOM   2551 N  N   . GLU A 1 328 ? 43.309 14.709  29.750 1.00 60.20  ? 767  GLU A N   1 
ATOM   2552 C  CA  . GLU A 1 328 ? 44.601 14.167  30.131 1.00 60.10  ? 767  GLU A CA  1 
ATOM   2553 C  C   . GLU A 1 328 ? 45.138 14.934  31.333 1.00 57.56  ? 767  GLU A C   1 
ATOM   2554 O  O   . GLU A 1 328 ? 44.841 16.117  31.519 1.00 57.82  ? 767  GLU A O   1 
ATOM   2555 C  CB  . GLU A 1 328 ? 45.570 14.238  28.951 1.00 60.50  ? 767  GLU A CB  1 
ATOM   2556 C  CG  . GLU A 1 328 ? 44.933 13.763  27.645 1.00 64.27  ? 767  GLU A CG  1 
ATOM   2557 C  CD  . GLU A 1 328 ? 45.879 13.800  26.457 1.00 66.13  ? 767  GLU A CD  1 
ATOM   2558 O  OE1 . GLU A 1 328 ? 46.778 14.669  26.423 1.00 63.74  ? 767  GLU A OE1 1 
ATOM   2559 O  OE2 . GLU A 1 328 ? 45.712 12.957  25.550 1.00 65.95  ? 767  GLU A OE2 1 
ATOM   2560 N  N   . LEU A 1 329 ? 45.923 14.241  32.162 1.00 56.44  ? 768  LEU A N   1 
ATOM   2561 C  CA  . LEU A 1 329 ? 46.280 14.795  33.466 1.00 57.83  ? 768  LEU A CA  1 
ATOM   2562 C  C   . LEU A 1 329 ? 47.082 16.083  33.332 1.00 57.24  ? 768  LEU A C   1 
ATOM   2563 O  O   . LEU A 1 329 ? 46.856 17.043  34.078 1.00 55.42  ? 768  LEU A O   1 
ATOM   2564 C  CB  . LEU A 1 329 ? 47.053 13.764  34.287 1.00 56.79  ? 768  LEU A CB  1 
ATOM   2565 C  CG  . LEU A 1 329 ? 47.417 14.241  35.695 1.00 56.01  ? 768  LEU A CG  1 
ATOM   2566 C  CD1 . LEU A 1 329 ? 46.207 14.173  36.618 1.00 54.45  ? 768  LEU A CD1 1 
ATOM   2567 C  CD2 . LEU A 1 329 ? 48.570 13.427  36.251 1.00 56.12  ? 768  LEU A CD2 1 
ATOM   2568 N  N   . HIS A 1 330 ? 48.023 16.124  32.386 1.00 58.83  ? 769  HIS A N   1 
ATOM   2569 C  CA  . HIS A 1 330 ? 48.812 17.335  32.174 1.00 57.74  ? 769  HIS A CA  1 
ATOM   2570 C  C   . HIS A 1 330 ? 47.930 18.502  31.744 1.00 58.66  ? 769  HIS A C   1 
ATOM   2571 O  O   . HIS A 1 330 ? 48.141 19.644  32.173 1.00 58.03  ? 769  HIS A O   1 
ATOM   2572 C  CB  . HIS A 1 330 ? 49.888 17.071  31.125 1.00 58.68  ? 769  HIS A CB  1 
ATOM   2573 C  CG  . HIS A 1 330 ? 49.338 16.863  29.748 1.00 59.98  ? 769  HIS A CG  1 
ATOM   2574 N  ND1 . HIS A 1 330 ? 49.282 17.870  28.808 1.00 59.76  ? 769  HIS A ND1 1 
ATOM   2575 C  CD2 . HIS A 1 330 ? 48.800 15.768  29.160 1.00 60.93  ? 769  HIS A CD2 1 
ATOM   2576 C  CE1 . HIS A 1 330 ? 48.743 17.402  27.697 1.00 62.65  ? 769  HIS A CE1 1 
ATOM   2577 N  NE2 . HIS A 1 330 ? 48.443 16.128  27.883 1.00 63.00  ? 769  HIS A NE2 1 
ATOM   2578 N  N   . SER A 1 331 ? 46.931 18.229  30.899 1.00 57.94  ? 770  SER A N   1 
ATOM   2579 C  CA  . SER A 1 331 ? 46.067 19.282  30.378 1.00 57.99  ? 770  SER A CA  1 
ATOM   2580 C  C   . SER A 1 331 ? 45.259 19.955  31.475 1.00 57.70  ? 770  SER A C   1 
ATOM   2581 O  O   . SER A 1 331 ? 44.854 21.112  31.311 1.00 59.48  ? 770  SER A O   1 
ATOM   2582 C  CB  . SER A 1 331 ? 45.125 18.709  29.309 1.00 56.77  ? 770  SER A CB  1 
ATOM   2583 O  OG  . SER A 1 331 ? 44.308 17.669  29.825 1.00 58.49  ? 770  SER A OG  1 
ATOM   2584 N  N   . ILE A 1 332 ? 45.021 19.261  32.586 1.00 55.41  ? 771  ILE A N   1 
ATOM   2585 C  CA  . ILE A 1 332 ? 44.191 19.815  33.648 1.00 55.53  ? 771  ILE A CA  1 
ATOM   2586 C  C   . ILE A 1 332 ? 44.882 21.001  34.309 1.00 55.41  ? 771  ILE A C   1 
ATOM   2587 O  O   . ILE A 1 332 ? 44.252 22.028  34.587 1.00 55.59  ? 771  ILE A O   1 
ATOM   2588 C  CB  . ILE A 1 332 ? 43.844 18.713  34.668 1.00 56.08  ? 771  ILE A CB  1 
ATOM   2589 C  CG1 . ILE A 1 332 ? 42.714 17.834  34.138 1.00 55.39  ? 771  ILE A CG1 1 
ATOM   2590 C  CG2 . ILE A 1 332 ? 43.475 19.308  36.013 1.00 53.50  ? 771  ILE A CG2 1 
ATOM   2591 C  CD1 . ILE A 1 332 ? 42.690 16.453  34.743 1.00 55.87  ? 771  ILE A CD1 1 
ATOM   2592 N  N   . PHE A 1 333 ? 46.185 20.893  34.546 1.00 56.27  ? 772  PHE A N   1 
ATOM   2593 C  CA  . PHE A 1 333 ? 46.900 21.826  35.405 1.00 55.20  ? 772  PHE A CA  1 
ATOM   2594 C  C   . PHE A 1 333 ? 47.540 22.949  34.601 1.00 57.09  ? 772  PHE A C   1 
ATOM   2595 O  O   . PHE A 1 333 ? 48.112 22.721  33.530 1.00 57.86  ? 772  PHE A O   1 
ATOM   2596 C  CB  . PHE A 1 333 ? 47.961 21.089  36.220 1.00 53.54  ? 772  PHE A CB  1 
ATOM   2597 C  CG  . PHE A 1 333 ? 47.392 20.033  37.110 1.00 52.36  ? 772  PHE A CG  1 
ATOM   2598 C  CD1 . PHE A 1 333 ? 47.045 20.326  38.415 1.00 50.52  ? 772  PHE A CD1 1 
ATOM   2599 C  CD2 . PHE A 1 333 ? 47.176 18.753  36.632 1.00 53.98  ? 772  PHE A CD2 1 
ATOM   2600 C  CE1 . PHE A 1 333 ? 46.508 19.358  39.232 1.00 51.82  ? 772  PHE A CE1 1 
ATOM   2601 C  CE2 . PHE A 1 333 ? 46.637 17.779  37.445 1.00 53.50  ? 772  PHE A CE2 1 
ATOM   2602 C  CZ  . PHE A 1 333 ? 46.303 18.083  38.748 1.00 50.99  ? 772  PHE A CZ  1 
ATOM   2603 N  N   . ARG A 1 334 ? 47.446 24.161  35.136 1.00 55.93  ? 773  ARG A N   1 
ATOM   2604 C  CA  . ARG A 1 334 ? 48.012 25.335  34.501 1.00 59.51  ? 773  ARG A CA  1 
ATOM   2605 C  C   . ARG A 1 334 ? 49.531 25.334  34.645 1.00 60.83  ? 773  ARG A C   1 
ATOM   2606 O  O   . ARG A 1 334 ? 50.075 24.731  35.573 1.00 59.61  ? 773  ARG A O   1 
ATOM   2607 C  CB  . ARG A 1 334 ? 47.407 26.597  35.110 1.00 59.08  ? 773  ARG A CB  1 
ATOM   2608 C  CG  . ARG A 1 334 ? 45.899 26.680  34.927 1.00 58.10  ? 773  ARG A CG  1 
ATOM   2609 C  CD  . ARG A 1 334 ? 45.230 27.426  36.061 1.00 58.68  ? 773  ARG A CD  1 
ATOM   2610 N  NE  . ARG A 1 334 ? 45.621 28.833  36.085 1.00 63.74  ? 773  ARG A NE  1 
ATOM   2611 C  CZ  . ARG A 1 334 ? 45.058 29.779  35.337 1.00 65.61  ? 773  ARG A CZ  1 
ATOM   2612 N  NH1 . ARG A 1 334 ? 44.073 29.469  34.505 1.00 65.50  ? 773  ARG A NH1 1 
ATOM   2613 N  NH2 . ARG A 1 334 ? 45.479 31.035  35.423 1.00 64.05  ? 773  ARG A NH2 1 
ATOM   2614 N  N   . PRO A 1 335 ? 50.239 25.996  33.722 1.00 62.85  ? 774  PRO A N   1 
ATOM   2615 C  CA  . PRO A 1 335 ? 51.711 25.921  33.729 1.00 62.56  ? 774  PRO A CA  1 
ATOM   2616 C  C   . PRO A 1 335 ? 52.354 26.288  35.056 1.00 60.51  ? 774  PRO A C   1 
ATOM   2617 O  O   . PRO A 1 335 ? 53.338 25.655  35.457 1.00 63.50  ? 774  PRO A O   1 
ATOM   2618 C  CB  . PRO A 1 335 ? 52.099 26.904  32.619 1.00 65.88  ? 774  PRO A CB  1 
ATOM   2619 C  CG  . PRO A 1 335 ? 50.947 26.873  31.682 1.00 65.37  ? 774  PRO A CG  1 
ATOM   2620 C  CD  . PRO A 1 335 ? 49.729 26.724  32.545 1.00 62.18  ? 774  PRO A CD  1 
ATOM   2621 N  N   . GLU A 1 336 ? 51.823 27.285  35.759 1.00 61.64  ? 775  GLU A N   1 
ATOM   2622 C  CA  . GLU A 1 336 ? 52.408 27.691  37.033 1.00 60.04  ? 775  GLU A CA  1 
ATOM   2623 C  C   . GLU A 1 336 ? 52.101 26.720  38.164 1.00 59.83  ? 775  GLU A C   1 
ATOM   2624 O  O   . GLU A 1 336 ? 52.523 26.966  39.300 1.00 59.11  ? 775  GLU A O   1 
ATOM   2625 C  CB  . GLU A 1 336 ? 51.924 29.092  37.406 1.00 56.75  ? 775  GLU A CB  1 
ATOM   2626 C  CG  . GLU A 1 336 ? 50.416 29.222  37.541 1.00 57.48  ? 775  GLU A CG  1 
ATOM   2627 C  CD  . GLU A 1 336 ? 49.720 29.487  36.216 1.00 61.57  ? 775  GLU A CD  1 
ATOM   2628 O  OE1 . GLU A 1 336 ? 50.373 29.385  35.153 1.00 60.71  ? 775  GLU A OE1 1 
ATOM   2629 O  OE2 . GLU A 1 336 ? 48.512 29.802  36.242 1.00 65.14  ? 775  GLU A OE2 1 
ATOM   2630 N  N   . HIS A 1 337 ? 51.383 25.632  37.891 1.00 58.84  ? 776  HIS A N   1 
ATOM   2631 C  CA  . HIS A 1 337 ? 51.060 24.634  38.901 1.00 58.46  ? 776  HIS A CA  1 
ATOM   2632 C  C   . HIS A 1 337 ? 51.668 23.283  38.549 1.00 58.38  ? 776  HIS A C   1 
ATOM   2633 O  O   . HIS A 1 337 ? 51.079 22.236  38.826 1.00 57.97  ? 776  HIS A O   1 
ATOM   2634 C  CB  . HIS A 1 337 ? 49.548 24.517  39.077 1.00 57.18  ? 776  HIS A CB  1 
ATOM   2635 C  CG  . HIS A 1 337 ? 48.892 25.795  39.492 1.00 55.06  ? 776  HIS A CG  1 
ATOM   2636 N  ND1 . HIS A 1 337 ? 47.668 26.196  39.004 1.00 53.96  ? 776  HIS A ND1 1 
ATOM   2637 C  CD2 . HIS A 1 337 ? 49.291 26.762  40.352 1.00 51.83  ? 776  HIS A CD2 1 
ATOM   2638 C  CE1 . HIS A 1 337 ? 47.340 27.355  39.546 1.00 55.11  ? 776  HIS A CE1 1 
ATOM   2639 N  NE2 . HIS A 1 337 ? 48.308 27.720  40.367 1.00 51.73  ? 776  HIS A NE2 1 
ATOM   2640 N  N   . ALA A 1 338 ? 52.848 23.298  37.925 1.00 58.46  ? 777  ALA A N   1 
ATOM   2641 C  CA  . ALA A 1 338 ? 53.505 22.046  37.566 1.00 58.05  ? 777  ALA A CA  1 
ATOM   2642 C  C   . ALA A 1 338 ? 53.879 21.239  38.800 1.00 57.72  ? 777  ALA A C   1 
ATOM   2643 O  O   . ALA A 1 338 ? 53.845 20.003  38.767 1.00 54.45  ? 777  ALA A O   1 
ATOM   2644 C  CB  . ALA A 1 338 ? 54.745 22.327  36.716 1.00 55.59  ? 777  ALA A CB  1 
ATOM   2645 N  N   . CYS A 1 339 ? 54.229 21.916  39.896 1.00 57.71  ? 778  CYS A N   1 
ATOM   2646 C  CA  . CYS A 1 339 ? 54.635 21.204  41.102 1.00 57.35  ? 778  CYS A CA  1 
ATOM   2647 C  C   . CYS A 1 339 ? 53.476 20.407  41.686 1.00 55.77  ? 778  CYS A C   1 
ATOM   2648 O  O   . CYS A 1 339 ? 53.673 19.286  42.168 1.00 57.83  ? 778  CYS A O   1 
ATOM   2649 C  CB  . CYS A 1 339 ? 55.191 22.186  42.131 1.00 57.79  ? 778  CYS A CB  1 
ATOM   2650 S  SG  . CYS A 1 339 ? 56.354 21.439  43.299 1.00 70.74  ? 778  CYS A SG  1 
ATOM   2651 N  N   . LEU A 1 340 ? 52.263 20.965  41.653 1.00 53.06  ? 779  LEU A N   1 
ATOM   2652 C  CA  . LEU A 1 340 ? 51.093 20.214  42.095 1.00 54.24  ? 779  LEU A CA  1 
ATOM   2653 C  C   . LEU A 1 340 ? 50.783 19.058  41.150 1.00 54.34  ? 779  LEU A C   1 
ATOM   2654 O  O   . LEU A 1 340 ? 50.262 18.024  41.584 1.00 53.49  ? 779  LEU A O   1 
ATOM   2655 C  CB  . LEU A 1 340 ? 49.885 21.145  42.221 1.00 52.98  ? 779  LEU A CB  1 
ATOM   2656 C  CG  . LEU A 1 340 ? 48.538 20.513  42.580 1.00 49.88  ? 779  LEU A CG  1 
ATOM   2657 C  CD1 . LEU A 1 340 ? 48.590 19.861  43.948 1.00 51.01  ? 779  LEU A CD1 1 
ATOM   2658 C  CD2 . LEU A 1 340 ? 47.428 21.542  42.522 1.00 48.14  ? 779  LEU A CD2 1 
ATOM   2659 N  N   . LEU A 1 341 ? 51.093 19.215  39.862 1.00 54.85  ? 780  LEU A N   1 
ATOM   2660 C  CA  . LEU A 1 341 ? 50.978 18.095  38.935 1.00 53.62  ? 780  LEU A CA  1 
ATOM   2661 C  C   . LEU A 1 341 ? 51.953 16.982  39.300 1.00 54.67  ? 780  LEU A C   1 
ATOM   2662 O  O   . LEU A 1 341 ? 51.613 15.797  39.216 1.00 55.50  ? 780  LEU A O   1 
ATOM   2663 C  CB  . LEU A 1 341 ? 51.218 18.580  37.505 1.00 53.99  ? 780  LEU A CB  1 
ATOM   2664 C  CG  . LEU A 1 341 ? 51.400 17.537  36.403 1.00 53.57  ? 780  LEU A CG  1 
ATOM   2665 C  CD1 . LEU A 1 341 ? 50.164 16.668  36.282 1.00 53.94  ? 780  LEU A CD1 1 
ATOM   2666 C  CD2 . LEU A 1 341 ? 51.700 18.219  35.081 1.00 55.22  ? 780  LEU A CD2 1 
ATOM   2667 N  N   . HIS A 1 342 ? 53.170 17.344  39.716 1.00 55.41  ? 781  HIS A N   1 
ATOM   2668 C  CA  . HIS A 1 342 ? 54.156 16.331  40.078 1.00 56.39  ? 781  HIS A CA  1 
ATOM   2669 C  C   . HIS A 1 342 ? 53.735 15.579  41.332 1.00 54.66  ? 781  HIS A C   1 
ATOM   2670 O  O   . HIS A 1 342 ? 53.919 14.360  41.420 1.00 51.74  ? 781  HIS A O   1 
ATOM   2671 C  CB  . HIS A 1 342 ? 55.527 16.974  40.279 1.00 55.05  ? 781  HIS A CB  1 
ATOM   2672 C  CG  . HIS A 1 342 ? 56.152 17.467  39.013 1.00 59.90  ? 781  HIS A CG  1 
ATOM   2673 N  ND1 . HIS A 1 342 ? 56.833 18.665  38.938 1.00 63.58  ? 781  HIS A ND1 1 
ATOM   2674 C  CD2 . HIS A 1 342 ? 56.198 16.928  37.772 1.00 59.30  ? 781  HIS A CD2 1 
ATOM   2675 C  CE1 . HIS A 1 342 ? 57.268 18.843  37.704 1.00 64.00  ? 781  HIS A CE1 1 
ATOM   2676 N  NE2 . HIS A 1 342 ? 56.896 17.805  36.976 1.00 63.25  ? 781  HIS A NE2 1 
ATOM   2677 N  N   . LEU A 1 343 ? 53.179 16.290  42.314 1.00 52.27  ? 782  LEU A N   1 
ATOM   2678 C  CA  . LEU A 1 343 ? 52.712 15.630  43.528 1.00 52.97  ? 782  LEU A CA  1 
ATOM   2679 C  C   . LEU A 1 343 ? 51.624 14.616  43.208 1.00 50.09  ? 782  LEU A C   1 
ATOM   2680 O  O   . LEU A 1 343 ? 51.644 13.484  43.703 1.00 49.23  ? 782  LEU A O   1 
ATOM   2681 C  CB  . LEU A 1 343 ? 52.200 16.669  44.525 1.00 52.91  ? 782  LEU A CB  1 
ATOM   2682 C  CG  . LEU A 1 343 ? 51.510 16.081  45.756 1.00 51.08  ? 782  LEU A CG  1 
ATOM   2683 C  CD1 . LEU A 1 343 ? 52.535 15.506  46.719 1.00 51.17  ? 782  LEU A CD1 1 
ATOM   2684 C  CD2 . LEU A 1 343 ? 50.647 17.123  46.441 1.00 51.11  ? 782  LEU A CD2 1 
ATOM   2685 N  N   . ILE A 1 344 ? 50.667 15.009  42.368 1.00 49.41  ? 783  ILE A N   1 
ATOM   2686 C  CA  . ILE A 1 344 ? 49.549 14.136  42.043 1.00 48.23  ? 783  ILE A CA  1 
ATOM   2687 C  C   . ILE A 1 344 ? 50.017 12.952  41.206 1.00 50.14  ? 783  ILE A C   1 
ATOM   2688 O  O   . ILE A 1 344 ? 49.433 11.861  41.279 1.00 51.66  ? 783  ILE A O   1 
ATOM   2689 C  CB  . ILE A 1 344 ? 48.446 14.965  41.355 1.00 46.89  ? 783  ILE A CB  1 
ATOM   2690 C  CG1 . ILE A 1 344 ? 47.839 15.939  42.370 1.00 46.41  ? 783  ILE A CG1 1 
ATOM   2691 C  CG2 . ILE A 1 344 ? 47.371 14.075  40.745 1.00 45.17  ? 783  ILE A CG2 1 
ATOM   2692 C  CD1 . ILE A 1 344 ? 46.646 16.712  41.878 1.00 45.24  ? 783  ILE A CD1 1 
ATOM   2693 N  N   . ARG A 1 345 ? 51.096 13.124  40.436 1.00 51.29  ? 784  ARG A N   1 
ATOM   2694 C  CA  . ARG A 1 345 ? 51.611 12.022  39.628 1.00 51.72  ? 784  ARG A CA  1 
ATOM   2695 C  C   . ARG A 1 345 ? 52.159 10.892  40.493 1.00 52.20  ? 784  ARG A C   1 
ATOM   2696 O  O   . ARG A 1 345 ? 52.094 9.723   40.095 1.00 52.76  ? 784  ARG A O   1 
ATOM   2697 C  CB  . ARG A 1 345 ? 52.690 12.528  38.670 1.00 53.68  ? 784  ARG A CB  1 
ATOM   2698 C  CG  . ARG A 1 345 ? 52.141 13.107  37.385 1.00 56.40  ? 784  ARG A CG  1 
ATOM   2699 C  CD  . ARG A 1 345 ? 53.200 13.908  36.650 1.00 59.22  ? 784  ARG A CD  1 
ATOM   2700 N  NE  . ARG A 1 345 ? 52.778 14.248  35.295 1.00 60.44  ? 784  ARG A NE  1 
ATOM   2701 C  CZ  . ARG A 1 345 ? 53.450 15.058  34.485 1.00 58.88  ? 784  ARG A CZ  1 
ATOM   2702 N  NH1 . ARG A 1 345 ? 54.582 15.611  34.894 1.00 59.76  ? 784  ARG A NH1 1 
ATOM   2703 N  NH2 . ARG A 1 345 ? 52.989 15.313  33.269 1.00 57.75  ? 784  ARG A NH2 1 
ATOM   2704 N  N   . CYS A 1 346 ? 52.704 11.214  41.668 1.00 48.93  ? 785  CYS A N   1 
ATOM   2705 C  CA  . CYS A 1 346 ? 53.101 10.174  42.609 1.00 51.71  ? 785  CYS A CA  1 
ATOM   2706 C  C   . CYS A 1 346 ? 51.920 9.576   43.356 1.00 50.53  ? 785  CYS A C   1 
ATOM   2707 O  O   . CYS A 1 346 ? 52.128 8.704   44.205 1.00 51.67  ? 785  CYS A O   1 
ATOM   2708 C  CB  . CYS A 1 346 ? 54.119 10.695  43.629 1.00 52.35  ? 785  CYS A CB  1 
ATOM   2709 S  SG  . CYS A 1 346 ? 55.222 11.962  43.049 1.00 55.17  ? 785  CYS A SG  1 
ATOM   2710 N  N   . CYS A 1 347 ? 50.698 10.001  43.052 1.00 49.39  ? 786  CYS A N   1 
ATOM   2711 C  CA  . CYS A 1 347 ? 49.506 9.490   43.707 1.00 48.05  ? 786  CYS A CA  1 
ATOM   2712 C  C   . CYS A 1 347 ? 48.661 8.653   42.761 1.00 48.76  ? 786  CYS A C   1 
ATOM   2713 O  O   . CYS A 1 347 ? 48.219 7.553   43.112 1.00 47.11  ? 786  CYS A O   1 
ATOM   2714 C  CB  . CYS A 1 347 ? 48.680 10.662  44.238 1.00 44.80  ? 786  CYS A CB  1 
ATOM   2715 S  SG  . CYS A 1 347 ? 49.465 11.555  45.537 1.00 42.51  ? 786  CYS A SG  1 
ATOM   2716 N  N   . LEU A 1 348 ? 48.426 9.152   41.553 1.00 50.67  ? 787  LEU A N   1 
ATOM   2717 C  CA  . LEU A 1 348 ? 47.550 8.493   40.590 1.00 45.53  ? 787  LEU A CA  1 
ATOM   2718 C  C   . LEU A 1 348 ? 48.357 7.606   39.646 1.00 48.97  ? 787  LEU A C   1 
ATOM   2719 O  O   . LEU A 1 348 ? 48.394 7.811   38.438 1.00 51.29  ? 787  LEU A O   1 
ATOM   2720 C  CB  . LEU A 1 348 ? 46.740 9.529   39.819 1.00 45.83  ? 787  LEU A CB  1 
ATOM   2721 C  CG  . LEU A 1 348 ? 45.824 10.443  40.629 1.00 46.07  ? 787  LEU A CG  1 
ATOM   2722 C  CD1 . LEU A 1 348 ? 45.051 11.386  39.712 1.00 42.71  ? 787  LEU A CD1 1 
ATOM   2723 C  CD2 . LEU A 1 348 ? 44.875 9.614   41.475 1.00 43.55  ? 787  LEU A CD2 1 
ATOM   2724 N  N   . THR A 1 349 ? 49.028 6.613   40.224 1.00 49.72  ? 788  THR A N   1 
ATOM   2725 C  CA  . THR A 1 349 ? 49.694 5.574   39.451 1.00 48.71  ? 788  THR A CA  1 
ATOM   2726 C  C   . THR A 1 349 ? 48.810 4.336   39.445 1.00 50.27  ? 788  THR A C   1 
ATOM   2727 O  O   . THR A 1 349 ? 48.281 3.943   40.489 1.00 50.53  ? 788  THR A O   1 
ATOM   2728 C  CB  . THR A 1 349 ? 51.078 5.246   40.017 1.00 52.16  ? 788  THR A CB  1 
ATOM   2729 O  OG1 . THR A 1 349 ? 50.946 4.507   41.238 1.00 51.47  ? 788  THR A OG1 1 
ATOM   2730 C  CG2 . THR A 1 349 ? 51.863 6.526   40.290 1.00 52.13  ? 788  THR A CG2 1 
ATOM   2731 N  N   . ILE A 1 350 ? 48.641 3.736   38.264 1.00 50.36  ? 789  ILE A N   1 
ATOM   2732 C  CA  . ILE A 1 350 ? 47.744 2.592   38.131 1.00 50.73  ? 789  ILE A CA  1 
ATOM   2733 C  C   . ILE A 1 350 ? 48.269 1.409   38.937 1.00 50.85  ? 789  ILE A C   1 
ATOM   2734 O  O   . ILE A 1 350 ? 47.522 0.754   39.675 1.00 49.11  ? 789  ILE A O   1 
ATOM   2735 C  CB  . ILE A 1 350 ? 47.554 2.235   36.646 1.00 50.92  ? 789  ILE A CB  1 
ATOM   2736 C  CG1 . ILE A 1 350 ? 46.636 3.258   35.978 1.00 51.15  ? 789  ILE A CG1 1 
ATOM   2737 C  CG2 . ILE A 1 350 ? 46.989 0.836   36.493 1.00 49.13  ? 789  ILE A CG2 1 
ATOM   2738 C  CD1 . ILE A 1 350 ? 46.630 3.173   34.472 1.00 55.18  ? 789  ILE A CD1 1 
ATOM   2739 N  N   . ASP A 1 351 ? 49.555 1.121   38.810 1.00 49.35  ? 790  ASP A N   1 
ATOM   2740 C  CA  . ASP A 1 351 ? 50.185 0.114   39.655 1.00 49.65  ? 790  ASP A CA  1 
ATOM   2741 C  C   . ASP A 1 351 ? 50.279 0.657   41.074 1.00 49.98  ? 790  ASP A C   1 
ATOM   2742 O  O   . ASP A 1 351 ? 50.961 1.666   41.295 1.00 49.50  ? 790  ASP A O   1 
ATOM   2743 C  CB  . ASP A 1 351 ? 51.571 -0.245  39.115 1.00 49.36  ? 790  ASP A CB  1 
ATOM   2744 C  CG  . ASP A 1 351 ? 52.323 -1.233  40.002 1.00 49.48  ? 790  ASP A CG  1 
ATOM   2745 O  OD1 . ASP A 1 351 ? 51.772 -1.700  41.019 1.00 50.19  ? 790  ASP A OD1 1 
ATOM   2746 O  OD2 . ASP A 1 351 ? 53.483 -1.552  39.672 1.00 49.24  ? 790  ASP A OD2 1 
ATOM   2747 N  N   . PRO A 1 352 ? 49.625 0.033   42.057 1.00 48.36  ? 791  PRO A N   1 
ATOM   2748 C  CA  . PRO A 1 352 ? 49.707 0.555   43.428 1.00 47.83  ? 791  PRO A CA  1 
ATOM   2749 C  C   . PRO A 1 352 ? 51.103 0.493   44.008 1.00 49.14  ? 791  PRO A C   1 
ATOM   2750 O  O   . PRO A 1 352 ? 51.398 1.235   44.952 1.00 50.73  ? 791  PRO A O   1 
ATOM   2751 C  CB  . PRO A 1 352 ? 48.737 -0.344  44.206 1.00 48.28  ? 791  PRO A CB  1 
ATOM   2752 C  CG  . PRO A 1 352 ? 48.681 -1.608  43.414 1.00 49.24  ? 791  PRO A CG  1 
ATOM   2753 C  CD  . PRO A 1 352 ? 48.799 -1.182  41.975 1.00 48.65  ? 791  PRO A CD  1 
ATOM   2754 N  N   . LEU A 1 353 ? 51.976 -0.359  43.468 1.00 51.60  ? 792  LEU A N   1 
ATOM   2755 C  CA  . LEU A 1 353 ? 53.319 -0.496  44.015 1.00 50.46  ? 792  LEU A CA  1 
ATOM   2756 C  C   . LEU A 1 353 ? 54.195 0.710   43.714 1.00 49.64  ? 792  LEU A C   1 
ATOM   2757 O  O   . LEU A 1 353 ? 55.234 0.876   44.361 1.00 50.62  ? 792  LEU A O   1 
ATOM   2758 C  CB  . LEU A 1 353 ? 53.974 -1.772  43.485 1.00 49.98  ? 792  LEU A CB  1 
ATOM   2759 C  CG  . LEU A 1 353 ? 53.394 -3.081  44.026 1.00 50.71  ? 792  LEU A CG  1 
ATOM   2760 C  CD1 . LEU A 1 353 ? 52.873 -3.963  42.904 1.00 52.49  ? 792  LEU A CD1 1 
ATOM   2761 C  CD2 . LEU A 1 353 ? 54.438 -3.817  44.836 1.00 57.73  ? 792  LEU A CD2 1 
ATOM   2762 N  N   . LYS A 1 354 ? 53.804 1.557   42.761 1.00 49.46  ? 793  LYS A N   1 
ATOM   2763 C  CA  . LYS A 1 354 ? 54.558 2.768   42.459 1.00 50.99  ? 793  LYS A CA  1 
ATOM   2764 C  C   . LYS A 1 354 ? 54.054 3.994   43.206 1.00 50.94  ? 793  LYS A C   1 
ATOM   2765 O  O   . LYS A 1 354 ? 54.678 5.056   43.108 1.00 53.37  ? 793  LYS A O   1 
ATOM   2766 C  CB  . LYS A 1 354 ? 54.541 3.073   40.954 1.00 52.43  ? 793  LYS A CB  1 
ATOM   2767 C  CG  . LYS A 1 354 ? 54.622 1.863   40.042 1.00 53.72  ? 793  LYS A CG  1 
ATOM   2768 C  CD  . LYS A 1 354 ? 54.062 2.194   38.663 1.00 57.06  ? 793  LYS A CD  1 
ATOM   2769 C  CE  . LYS A 1 354 ? 54.646 1.294   37.579 1.00 58.60  ? 793  LYS A CE  1 
ATOM   2770 N  NZ  . LYS A 1 354 ? 53.793 1.288   36.354 1.00 59.57  ? 793  LYS A NZ  1 
ATOM   2771 N  N   . ARG A 1 355 ? 52.949 3.884   43.936 1.00 50.32  ? 794  ARG A N   1 
ATOM   2772 C  CA  . ARG A 1 355 ? 52.452 5.017   44.702 1.00 48.73  ? 794  ARG A CA  1 
ATOM   2773 C  C   . ARG A 1 355 ? 53.369 5.308   45.884 1.00 49.08  ? 794  ARG A C   1 
ATOM   2774 O  O   . ARG A 1 355 ? 53.959 4.405   46.481 1.00 50.66  ? 794  ARG A O   1 
ATOM   2775 C  CB  . ARG A 1 355 ? 51.031 4.745   45.192 1.00 47.81  ? 794  ARG A CB  1 
ATOM   2776 C  CG  . ARG A 1 355 ? 49.963 5.102   44.183 1.00 46.64  ? 794  ARG A CG  1 
ATOM   2777 C  CD  . ARG A 1 355 ? 48.626 4.500   44.554 1.00 46.62  ? 794  ARG A CD  1 
ATOM   2778 N  NE  . ARG A 1 355 ? 47.950 3.933   43.390 1.00 48.31  ? 794  ARG A NE  1 
ATOM   2779 C  CZ  . ARG A 1 355 ? 47.002 3.005   43.453 1.00 46.52  ? 794  ARG A CZ  1 
ATOM   2780 N  NH1 . ARG A 1 355 ? 46.604 2.538   44.630 1.00 43.65  ? 794  ARG A NH1 1 
ATOM   2781 N  NH2 . ARG A 1 355 ? 46.449 2.549   42.338 1.00 47.26  ? 794  ARG A NH2 1 
ATOM   2782 N  N   . TRP A 1 356 ? 53.491 6.587   46.219 1.00 48.44  ? 795  TRP A N   1 
ATOM   2783 C  CA  . TRP A 1 356 ? 54.338 6.983   47.332 1.00 49.88  ? 795  TRP A CA  1 
ATOM   2784 C  C   . TRP A 1 356 ? 53.629 6.742   48.661 1.00 50.69  ? 795  TRP A C   1 
ATOM   2785 O  O   . TRP A 1 356 ? 52.398 6.719   48.741 1.00 49.54  ? 795  TRP A O   1 
ATOM   2786 C  CB  . TRP A 1 356 ? 54.721 8.459   47.228 1.00 52.13  ? 795  TRP A CB  1 
ATOM   2787 C  CG  . TRP A 1 356 ? 55.714 8.793   46.151 1.00 53.88  ? 795  TRP A CG  1 
ATOM   2788 C  CD1 . TRP A 1 356 ? 55.962 8.088   45.009 1.00 53.65  ? 795  TRP A CD1 1 
ATOM   2789 C  CD2 . TRP A 1 356 ? 56.581 9.932   46.115 1.00 52.27  ? 795  TRP A CD2 1 
ATOM   2790 N  NE1 . TRP A 1 356 ? 56.933 8.717   44.267 1.00 52.70  ? 795  TRP A NE1 1 
ATOM   2791 C  CE2 . TRP A 1 356 ? 57.329 9.851   44.925 1.00 53.00  ? 795  TRP A CE2 1 
ATOM   2792 C  CE3 . TRP A 1 356 ? 56.798 11.013  46.977 1.00 53.64  ? 795  TRP A CE3 1 
ATOM   2793 C  CZ2 . TRP A 1 356 ? 58.280 10.808  44.574 1.00 53.45  ? 795  TRP A CZ2 1 
ATOM   2794 C  CZ3 . TRP A 1 356 ? 57.743 11.964  46.626 1.00 55.51  ? 795  TRP A CZ3 1 
ATOM   2795 C  CH2 . TRP A 1 356 ? 58.471 11.854  45.435 1.00 54.26  ? 795  TRP A CH2 1 
ATOM   2796 N  N   . ARG A 1 357 ? 54.423 6.562   49.710 1.00 51.62  ? 796  ARG A N   1 
ATOM   2797 C  CA  . ARG A 1 357 ? 53.880 6.582   51.054 1.00 50.44  ? 796  ARG A CA  1 
ATOM   2798 C  C   . ARG A 1 357 ? 53.482 8.012   51.417 1.00 51.19  ? 796  ARG A C   1 
ATOM   2799 O  O   . ARG A 1 357 ? 54.084 8.973   50.928 1.00 52.53  ? 796  ARG A O   1 
ATOM   2800 C  CB  . ARG A 1 357 ? 54.903 6.052   52.057 1.00 53.37  ? 796  ARG A CB  1 
ATOM   2801 C  CG  . ARG A 1 357 ? 55.910 5.072   51.465 1.00 57.56  ? 796  ARG A CG  1 
ATOM   2802 C  CD  . ARG A 1 357 ? 56.826 4.480   52.532 1.00 59.59  ? 796  ARG A CD  1 
ATOM   2803 N  NE  . ARG A 1 357 ? 56.073 3.748   53.547 1.00 64.66  ? 796  ARG A NE  1 
ATOM   2804 C  CZ  . ARG A 1 357 ? 55.615 2.509   53.391 1.00 69.58  ? 796  ARG A CZ  1 
ATOM   2805 N  NH1 . ARG A 1 357 ? 55.834 1.853   52.257 1.00 66.46  ? 796  ARG A NH1 1 
ATOM   2806 N  NH2 . ARG A 1 357 ? 54.934 1.926   54.370 1.00 68.20  ? 796  ARG A NH2 1 
ATOM   2807 N  N   . PRO A 1 358 ? 52.460 8.185   52.260 1.00 50.34  ? 797  PRO A N   1 
ATOM   2808 C  CA  . PRO A 1 358 ? 52.055 9.552   52.626 1.00 47.82  ? 797  PRO A CA  1 
ATOM   2809 C  C   . PRO A 1 358 ? 53.154 10.337  53.319 1.00 49.90  ? 797  PRO A C   1 
ATOM   2810 O  O   . PRO A 1 358 ? 53.175 11.570  53.217 1.00 50.12  ? 797  PRO A O   1 
ATOM   2811 C  CB  . PRO A 1 358 ? 50.841 9.329   53.542 1.00 45.82  ? 797  PRO A CB  1 
ATOM   2812 C  CG  . PRO A 1 358 ? 50.956 7.921   54.006 1.00 47.29  ? 797  PRO A CG  1 
ATOM   2813 C  CD  . PRO A 1 358 ? 51.599 7.168   52.884 1.00 49.31  ? 797  PRO A CD  1 
ATOM   2814 N  N   . SER A 1 359 ? 54.074 9.662   54.017 1.00 49.98  ? 798  SER A N   1 
ATOM   2815 C  CA  . SER A 1 359 ? 55.210 10.364  54.608 1.00 50.32  ? 798  SER A CA  1 
ATOM   2816 C  C   . SER A 1 359 ? 56.153 10.895  53.537 1.00 52.17  ? 798  SER A C   1 
ATOM   2817 O  O   . SER A 1 359 ? 56.751 11.965  53.711 1.00 49.28  ? 798  SER A O   1 
ATOM   2818 C  CB  . SER A 1 359 ? 55.968 9.443   55.568 1.00 49.93  ? 798  SER A CB  1 
ATOM   2819 O  OG  . SER A 1 359 ? 56.818 8.547   54.869 1.00 50.74  ? 798  SER A OG  1 
ATOM   2820 N  N   . GLU A 1 360 ? 56.302 10.160  52.432 1.00 51.44  ? 799  GLU A N   1 
ATOM   2821 C  CA  . GLU A 1 360 ? 57.137 10.632  51.335 1.00 51.67  ? 799  GLU A CA  1 
ATOM   2822 C  C   . GLU A 1 360 ? 56.478 11.797  50.608 1.00 51.10  ? 799  GLU A C   1 
ATOM   2823 O  O   . GLU A 1 360 ? 57.154 12.755  50.218 1.00 51.58  ? 799  GLU A O   1 
ATOM   2824 C  CB  . GLU A 1 360 ? 57.429 9.483   50.371 1.00 51.39  ? 799  GLU A CB  1 
ATOM   2825 C  CG  . GLU A 1 360 ? 58.292 8.384   50.972 1.00 54.19  ? 799  GLU A CG  1 
ATOM   2826 C  CD  . GLU A 1 360 ? 58.510 7.218   50.024 1.00 55.74  ? 799  GLU A CD  1 
ATOM   2827 O  OE1 . GLU A 1 360 ? 57.566 6.856   49.291 1.00 53.81  ? 799  GLU A OE1 1 
ATOM   2828 O  OE2 . GLU A 1 360 ? 59.629 6.662   50.013 1.00 61.38  ? 799  GLU A OE2 1 
ATOM   2829 N  N   . LEU A 1 361 ? 55.158 11.735  50.424 1.00 50.51  ? 800  LEU A N   1 
ATOM   2830 C  CA  . LEU A 1 361 ? 54.454 12.825  49.757 1.00 50.57  ? 800  LEU A CA  1 
ATOM   2831 C  C   . LEU A 1 361 ? 54.500 14.111  50.573 1.00 49.30  ? 800  LEU A C   1 
ATOM   2832 O  O   . LEU A 1 361 ? 54.529 15.204  50.000 1.00 50.55  ? 800  LEU A O   1 
ATOM   2833 C  CB  . LEU A 1 361 ? 53.005 12.418  49.481 1.00 49.20  ? 800  LEU A CB  1 
ATOM   2834 C  CG  . LEU A 1 361 ? 52.802 11.288  48.472 1.00 47.18  ? 800  LEU A CG  1 
ATOM   2835 C  CD1 . LEU A 1 361 ? 51.464 10.630  48.696 1.00 48.16  ? 800  LEU A CD1 1 
ATOM   2836 C  CD2 . LEU A 1 361 ? 52.901 11.808  47.051 1.00 49.62  ? 800  LEU A CD2 1 
ATOM   2837 N  N   . LEU A 1 362 ? 54.507 14.006  51.904 1.00 49.22  ? 801  LEU A N   1 
ATOM   2838 C  CA  . LEU A 1 362 ? 54.620 15.192  52.745 1.00 50.77  ? 801  LEU A CA  1 
ATOM   2839 C  C   . LEU A 1 362 ? 55.958 15.902  52.566 1.00 52.36  ? 801  LEU A C   1 
ATOM   2840 O  O   . LEU A 1 362 ? 56.049 17.103  52.846 1.00 48.95  ? 801  LEU A O   1 
ATOM   2841 C  CB  . LEU A 1 362 ? 54.418 14.820  54.215 1.00 50.19  ? 801  LEU A CB  1 
ATOM   2842 C  CG  . LEU A 1 362 ? 52.974 14.886  54.722 1.00 49.38  ? 801  LEU A CG  1 
ATOM   2843 C  CD1 . LEU A 1 362 ? 52.891 14.605  56.214 1.00 48.15  ? 801  LEU A CD1 1 
ATOM   2844 C  CD2 . LEU A 1 362 ? 52.353 16.236  54.391 1.00 48.18  ? 801  LEU A CD2 1 
ATOM   2845 N  N   . ARG A 1 363 ? 56.989 15.191  52.111 1.00 52.40  ? 802  ARG A N   1 
ATOM   2846 C  CA  . ARG A 1 363 ? 58.288 15.782  51.822 1.00 52.21  ? 802  ARG A CA  1 
ATOM   2847 C  C   . ARG A 1 363 ? 58.427 16.194  50.363 1.00 51.74  ? 802  ARG A C   1 
ATOM   2848 O  O   . ARG A 1 363 ? 59.525 16.559  49.935 1.00 53.02  ? 802  ARG A O   1 
ATOM   2849 C  CB  . ARG A 1 363 ? 59.410 14.808  52.193 1.00 52.92  ? 802  ARG A CB  1 
ATOM   2850 C  CG  . ARG A 1 363 ? 59.614 14.615  53.691 1.00 53.13  ? 802  ARG A CG  1 
ATOM   2851 C  CD  . ARG A 1 363 ? 60.045 13.186  54.007 1.00 57.59  ? 802  ARG A CD  1 
ATOM   2852 N  NE  . ARG A 1 363 ? 61.101 12.720  53.109 1.00 61.25  ? 802  ARG A NE  1 
ATOM   2853 C  CZ  . ARG A 1 363 ? 61.318 11.445  52.794 1.00 60.80  ? 802  ARG A CZ  1 
ATOM   2854 N  NH1 . ARG A 1 363 ? 60.551 10.489  53.302 1.00 56.85  ? 802  ARG A NH1 1 
ATOM   2855 N  NH2 . ARG A 1 363 ? 62.306 11.125  51.964 1.00 59.62  ? 802  ARG A NH2 1 
ATOM   2856 N  N   . HIS A 1 364 ? 57.346 16.138  49.595 1.00 51.73  ? 803  HIS A N   1 
ATOM   2857 C  CA  . HIS A 1 364 ? 57.399 16.540  48.202 1.00 54.19  ? 803  HIS A CA  1 
ATOM   2858 C  C   . HIS A 1 364 ? 57.595 18.053  48.095 1.00 54.87  ? 803  HIS A C   1 
ATOM   2859 O  O   . HIS A 1 364 ? 57.152 18.806  48.968 1.00 53.60  ? 803  HIS A O   1 
ATOM   2860 C  CB  . HIS A 1 364 ? 56.118 16.123  47.486 1.00 53.40  ? 803  HIS A CB  1 
ATOM   2861 C  CG  . HIS A 1 364 ? 56.193 16.234  45.998 1.00 54.65  ? 803  HIS A CG  1 
ATOM   2862 N  ND1 . HIS A 1 364 ? 55.913 17.404  45.326 1.00 55.06  ? 803  HIS A ND1 1 
ATOM   2863 C  CD2 . HIS A 1 364 ? 56.522 15.325  45.051 1.00 53.33  ? 803  HIS A CD2 1 
ATOM   2864 C  CE1 . HIS A 1 364 ? 56.061 17.208  44.028 1.00 54.73  ? 803  HIS A CE1 1 
ATOM   2865 N  NE2 . HIS A 1 364 ? 56.432 15.956  43.835 1.00 52.14  ? 803  HIS A NE2 1 
ATOM   2866 N  N   . PRO A 1 365 ? 58.275 18.518  47.042 1.00 55.11  ? 804  PRO A N   1 
ATOM   2867 C  CA  . PRO A 1 365 ? 58.514 19.965  46.893 1.00 55.82  ? 804  PRO A CA  1 
ATOM   2868 C  C   . PRO A 1 365 ? 57.257 20.820  46.920 1.00 56.56  ? 804  PRO A C   1 
ATOM   2869 O  O   . PRO A 1 365 ? 57.332 21.991  47.315 1.00 57.59  ? 804  PRO A O   1 
ATOM   2870 C  CB  . PRO A 1 365 ? 59.219 20.049  45.533 1.00 58.11  ? 804  PRO A CB  1 
ATOM   2871 C  CG  . PRO A 1 365 ? 59.951 18.755  45.430 1.00 56.11  ? 804  PRO A CG  1 
ATOM   2872 C  CD  . PRO A 1 365 ? 59.061 17.730  46.074 1.00 52.83  ? 804  PRO A CD  1 
ATOM   2873 N  N   . PHE A 1 366 ? 56.105 20.276  46.514 1.00 56.55  ? 805  PHE A N   1 
ATOM   2874 C  CA  . PHE A 1 366 ? 54.870 21.056  46.523 1.00 54.42  ? 805  PHE A CA  1 
ATOM   2875 C  C   . PHE A 1 366 ? 54.551 21.600  47.909 1.00 53.88  ? 805  PHE A C   1 
ATOM   2876 O  O   . PHE A 1 366 ? 53.903 22.644  48.030 1.00 55.97  ? 805  PHE A O   1 
ATOM   2877 C  CB  . PHE A 1 366 ? 53.709 20.203  46.011 1.00 52.77  ? 805  PHE A CB  1 
ATOM   2878 C  CG  . PHE A 1 366 ? 52.353 20.822  46.224 1.00 53.74  ? 805  PHE A CG  1 
ATOM   2879 C  CD1 . PHE A 1 366 ? 51.873 21.788  45.354 1.00 53.60  ? 805  PHE A CD1 1 
ATOM   2880 C  CD2 . PHE A 1 366 ? 51.553 20.432  47.289 1.00 52.14  ? 805  PHE A CD2 1 
ATOM   2881 C  CE1 . PHE A 1 366 ? 50.623 22.353  45.543 1.00 50.90  ? 805  PHE A CE1 1 
ATOM   2882 C  CE2 . PHE A 1 366 ? 50.305 20.995  47.482 1.00 51.18  ? 805  PHE A CE2 1 
ATOM   2883 C  CZ  . PHE A 1 366 ? 49.840 21.957  46.607 1.00 49.71  ? 805  PHE A CZ  1 
ATOM   2884 N  N   . PHE A 1 367 ? 54.987 20.914  48.961 1.00 56.08  ? 806  PHE A N   1 
ATOM   2885 C  CA  . PHE A 1 367 ? 54.701 21.329  50.326 1.00 56.61  ? 806  PHE A CA  1 
ATOM   2886 C  C   . PHE A 1 367 ? 55.810 22.181  50.922 1.00 61.65  ? 806  PHE A C   1 
ATOM   2887 O  O   . PHE A 1 367 ? 55.831 22.390  52.140 1.00 62.34  ? 806  PHE A O   1 
ATOM   2888 C  CB  . PHE A 1 367 ? 54.442 20.104  51.204 1.00 51.18  ? 806  PHE A CB  1 
ATOM   2889 C  CG  . PHE A 1 367 ? 53.191 19.366  50.843 1.00 49.63  ? 806  PHE A CG  1 
ATOM   2890 C  CD1 . PHE A 1 367 ? 51.949 19.903  51.131 1.00 48.02  ? 806  PHE A CD1 1 
ATOM   2891 C  CD2 . PHE A 1 367 ? 53.256 18.144  50.197 1.00 49.66  ? 806  PHE A CD2 1 
ATOM   2892 C  CE1 . PHE A 1 367 ? 50.795 19.232  50.793 1.00 47.76  ? 806  PHE A CE1 1 
ATOM   2893 C  CE2 . PHE A 1 367 ? 52.106 17.466  49.855 1.00 47.90  ? 806  PHE A CE2 1 
ATOM   2894 C  CZ  . PHE A 1 367 ? 50.872 18.009  50.154 1.00 48.94  ? 806  PHE A CZ  1 
ATOM   2895 N  N   . MET A 1 368 ? 56.726 22.672  50.094 1.00 62.04  ? 807  MET A N   1 
ATOM   2896 C  CA  . MET A 1 368 ? 57.744 23.607  50.546 1.00 66.13  ? 807  MET A CA  1 
ATOM   2897 C  C   . MET A 1 368 ? 58.220 24.473  49.381 1.00 67.62  ? 807  MET A C   1 
ATOM   2898 O  O   . MET A 1 368 ? 57.608 25.496  49.066 1.00 68.50  ? 807  MET A O   1 
ATOM   2899 C  CB  . MET A 1 368 ? 58.922 22.865  51.183 1.00 64.92  ? 807  MET A CB  1 
ATOM   2900 C  CG  . MET A 1 368 ? 59.957 23.800  51.778 1.00 69.89  ? 807  MET A CG  1 
ATOM   2901 S  SD  . MET A 1 368 ? 59.172 25.215  52.582 1.00 82.16  ? 807  MET A SD  1 
ATOM   2902 C  CE  . MET A 1 368 ? 60.222 26.565  52.032 1.00 65.18  ? 807  MET A CE  1 
HETATM 2903 C  C1  . EDO B 2 .   ? 34.361 -3.387  41.260 1.00 51.84  ? 901  EDO A C1  1 
HETATM 2904 O  O1  . EDO B 2 .   ? 34.313 -1.966  41.078 1.00 50.67  ? 901  EDO A O1  1 
HETATM 2905 C  C2  . EDO B 2 .   ? 32.946 -3.948  41.351 1.00 51.93  ? 901  EDO A C2  1 
HETATM 2906 O  O2  . EDO B 2 .   ? 32.257 -3.744  40.111 1.00 56.28  ? 901  EDO A O2  1 
HETATM 2907 ZN ZN  . ZN  C 3 .   ? 58.459 21.232  41.575 1.00 103.53 ? 902  ZN  A ZN  1 
HETATM 2908 O  O   . HOH D 4 .   ? 49.422 14.023  31.940 1.00 60.04  ? 1001 HOH A O   1 
HETATM 2909 O  O   . HOH D 4 .   ? 29.532 1.915   40.736 1.00 56.91  ? 1002 HOH A O   1 
HETATM 2910 O  O   . HOH D 4 .   ? 46.269 -10.930 45.069 1.00 41.76  ? 1003 HOH A O   1 
HETATM 2911 O  O   . HOH D 4 .   ? 36.916 11.228  75.671 1.00 56.52  ? 1004 HOH A O   1 
HETATM 2912 O  O   . HOH D 4 .   ? 36.266 4.267   56.546 1.00 47.37  ? 1005 HOH A O   1 
HETATM 2913 O  O   . HOH D 4 .   ? 48.610 -3.940  47.093 1.00 48.01  ? 1006 HOH A O   1 
HETATM 2914 O  O   . HOH D 4 .   ? 31.928 13.951  45.202 1.00 54.85  ? 1007 HOH A O   1 
HETATM 2915 O  O   . HOH D 4 .   ? 56.885 3.488   47.669 1.00 49.45  ? 1008 HOH A O   1 
HETATM 2916 O  O   . HOH D 4 .   ? 35.594 14.225  33.897 1.00 55.08  ? 1009 HOH A O   1 
HETATM 2917 O  O   . HOH D 4 .   ? 52.111 24.704  42.148 1.00 52.96  ? 1010 HOH A O   1 
HETATM 2918 O  O   . HOH D 4 .   ? 29.641 -0.073  43.018 1.00 59.57  ? 1011 HOH A O   1 
HETATM 2919 O  O   . HOH D 4 .   ? 41.671 -8.566  60.504 1.00 47.52  ? 1012 HOH A O   1 
HETATM 2920 O  O   . HOH D 4 .   ? 49.333 -2.855  66.146 1.00 53.74  ? 1013 HOH A O   1 
# 
