data_9FL8
# 
_entry.id   9FL8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FL8         pdb_00009fl8 10.2210/pdb9fl8/pdb 
WWPDB D_1292139053 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FL8 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 raphael.gasper@mpi-dortmund.mpg.de Raphael Gasper   ? 'principal investigator/group leader' 0000-0002-7780-0773 
4 peter.t-hart@mpi-dortmund.mpg.de   Peter   't Hart' ? 'principal investigator/group leader' 0000-0003-3488-4409 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Pal, S.'      1 0000-0001-7526-5570 
'Schmeing, S.' 2 0000-0001-8202-8549 
'Gasper, R.'   3 0000-0002-7780-0773 
't Hart, P.'   4 0000-0003-3488-4409 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   GE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Angew.Chem.Int.Ed.Engl. 
_citation.journal_id_ASTM           ACIEAY 
_citation.journal_id_CSD            0179 
_citation.journal_id_ISSN           1521-3773 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            64 
_citation.language                  ? 
_citation.page_first                e202413911 
_citation.page_last                 e202413911 
_citation.title                     'Stapled Peptides as Inhibitors of mRNA Deadenylation.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/anie.202413911 
_citation.pdbx_database_id_PubMed   39319385 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pal, S.'        1 0000-0001-7526-5570 
primary 'Gordijenko, I.' 2 0009-0001-7719-9674 
primary 'Schmeing, S.'   3 0000-0001-8202-8549 
primary 'Biswas, S.'     4 0009-0000-6847-3611 
primary 'Akbulut, Y.'    5 ?                   
primary 'Gasper, R.'     6 0000-0002-7780-0773 
primary 
;'t Hart, P.
;
7 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 'Protein bag of marbles'                   2063.458  2  ? ? ? ? 
2 polymer     man 'CCR4-NOT transcription complex subunit 9' 31072.189 2  ? ? ? ? 
3 polymer     man 'CCR4-NOT transcription complex subunit 1' 27617.930 2  ? ? ? ? 
4 non-polymer syn 1,4-BUTANEDIOL                             90.121    6  ? ? ? ? 
5 water       nat water                                      18.015    46 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'CAF40-binding motif domain peptide'                                                   
2 'Cell differentiation protein RQCD1 homolog,Rcd-1'                                     
3 'CCR4-associated factor 1,Negative regulator of transcription subunit 1 homolog,hNOT1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes '(ACE)LD(MK8)NFK(MK8)(NLE)EEHLAL(NLE)VE(NH2)' XLDLNFKLLEEHLALLVEX G,F ? 
2 'polypeptide(L)' no no  
;GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCN
ALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIME
SGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQC
LPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE
;
;GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCN
ALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIME
SGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQC
LPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE
;
B,C ? 
3 'polypeptide(L)' no no  
;GPHMLEVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIV
RKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELAC
CFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLP
TNDL
;
;GPHMLEVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIV
RKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELAC
CFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLP
TNDL
;
A,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 1,4-BUTANEDIOL BU1 
5 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ACE n 
1 2   LEU n 
1 3   ASP n 
1 4   MK8 n 
1 5   ASN n 
1 6   PHE n 
1 7   LYS n 
1 8   MK8 n 
1 9   NLE n 
1 10  GLU n 
1 11  GLU n 
1 12  HIS n 
1 13  LEU n 
1 14  ALA n 
1 15  LEU n 
1 16  NLE n 
1 17  VAL n 
1 18  GLU n 
1 19  NH2 n 
2 1   GLY n 
2 2   PRO n 
2 3   HIS n 
2 4   MET n 
2 5   LEU n 
2 6   GLU n 
2 7   ARG n 
2 8   GLU n 
2 9   LYS n 
2 10  ILE n 
2 11  TYR n 
2 12  GLN n 
2 13  TRP n 
2 14  ILE n 
2 15  ASN n 
2 16  GLU n 
2 17  LEU n 
2 18  SER n 
2 19  SER n 
2 20  PRO n 
2 21  GLU n 
2 22  THR n 
2 23  ARG n 
2 24  GLU n 
2 25  ASN n 
2 26  ALA n 
2 27  LEU n 
2 28  LEU n 
2 29  GLU n 
2 30  LEU n 
2 31  SER n 
2 32  LYS n 
2 33  LYS n 
2 34  ARG n 
2 35  GLU n 
2 36  SER n 
2 37  VAL n 
2 38  PRO n 
2 39  ASP n 
2 40  LEU n 
2 41  ALA n 
2 42  PRO n 
2 43  MET n 
2 44  LEU n 
2 45  TRP n 
2 46  HIS n 
2 47  SER n 
2 48  PHE n 
2 49  GLY n 
2 50  THR n 
2 51  ILE n 
2 52  ALA n 
2 53  ALA n 
2 54  LEU n 
2 55  LEU n 
2 56  GLN n 
2 57  GLU n 
2 58  ILE n 
2 59  VAL n 
2 60  ASN n 
2 61  ILE n 
2 62  TYR n 
2 63  PRO n 
2 64  SER n 
2 65  ILE n 
2 66  ASN n 
2 67  PRO n 
2 68  PRO n 
2 69  THR n 
2 70  LEU n 
2 71  THR n 
2 72  ALA n 
2 73  HIS n 
2 74  GLN n 
2 75  SER n 
2 76  ASN n 
2 77  ARG n 
2 78  VAL n 
2 79  CYS n 
2 80  ASN n 
2 81  ALA n 
2 82  LEU n 
2 83  ALA n 
2 84  LEU n 
2 85  LEU n 
2 86  GLN n 
2 87  CYS n 
2 88  VAL n 
2 89  ALA n 
2 90  SER n 
2 91  HIS n 
2 92  PRO n 
2 93  GLU n 
2 94  THR n 
2 95  ARG n 
2 96  SER n 
2 97  ALA n 
2 98  PHE n 
2 99  LEU n 
2 100 ALA n 
2 101 ALA n 
2 102 HIS n 
2 103 ILE n 
2 104 PRO n 
2 105 LEU n 
2 106 PHE n 
2 107 LEU n 
2 108 TYR n 
2 109 PRO n 
2 110 PHE n 
2 111 LEU n 
2 112 HIS n 
2 113 THR n 
2 114 VAL n 
2 115 SER n 
2 116 LYS n 
2 117 THR n 
2 118 ARG n 
2 119 PRO n 
2 120 PHE n 
2 121 GLU n 
2 122 TYR n 
2 123 LEU n 
2 124 ARG n 
2 125 LEU n 
2 126 THR n 
2 127 SER n 
2 128 LEU n 
2 129 GLY n 
2 130 VAL n 
2 131 ILE n 
2 132 GLY n 
2 133 ALA n 
2 134 LEU n 
2 135 VAL n 
2 136 LYS n 
2 137 THR n 
2 138 ASP n 
2 139 GLU n 
2 140 GLN n 
2 141 GLU n 
2 142 VAL n 
2 143 ILE n 
2 144 ASN n 
2 145 PHE n 
2 146 LEU n 
2 147 LEU n 
2 148 THR n 
2 149 THR n 
2 150 GLU n 
2 151 ILE n 
2 152 ILE n 
2 153 PRO n 
2 154 LEU n 
2 155 CYS n 
2 156 LEU n 
2 157 ARG n 
2 158 ILE n 
2 159 MET n 
2 160 GLU n 
2 161 SER n 
2 162 GLY n 
2 163 SER n 
2 164 GLU n 
2 165 LEU n 
2 166 SER n 
2 167 LYS n 
2 168 THR n 
2 169 VAL n 
2 170 ALA n 
2 171 THR n 
2 172 PHE n 
2 173 ILE n 
2 174 LEU n 
2 175 GLN n 
2 176 LYS n 
2 177 ILE n 
2 178 LEU n 
2 179 LEU n 
2 180 ASP n 
2 181 ASP n 
2 182 THR n 
2 183 GLY n 
2 184 LEU n 
2 185 ALA n 
2 186 TYR n 
2 187 ILE n 
2 188 CYS n 
2 189 GLN n 
2 190 THR n 
2 191 TYR n 
2 192 GLU n 
2 193 ARG n 
2 194 PHE n 
2 195 SER n 
2 196 HIS n 
2 197 VAL n 
2 198 ALA n 
2 199 MET n 
2 200 ILE n 
2 201 LEU n 
2 202 GLY n 
2 203 LYS n 
2 204 MET n 
2 205 VAL n 
2 206 LEU n 
2 207 GLN n 
2 208 LEU n 
2 209 SER n 
2 210 LYS n 
2 211 GLU n 
2 212 PRO n 
2 213 SER n 
2 214 ALA n 
2 215 ARG n 
2 216 LEU n 
2 217 LEU n 
2 218 LYS n 
2 219 HIS n 
2 220 VAL n 
2 221 VAL n 
2 222 ARG n 
2 223 CYS n 
2 224 TYR n 
2 225 LEU n 
2 226 ARG n 
2 227 LEU n 
2 228 SER n 
2 229 ASP n 
2 230 ASN n 
2 231 PRO n 
2 232 ARG n 
2 233 ALA n 
2 234 ARG n 
2 235 GLU n 
2 236 ALA n 
2 237 LEU n 
2 238 ARG n 
2 239 GLN n 
2 240 CYS n 
2 241 LEU n 
2 242 PRO n 
2 243 ASP n 
2 244 GLN n 
2 245 LEU n 
2 246 LYS n 
2 247 ASP n 
2 248 THR n 
2 249 THR n 
2 250 PHE n 
2 251 ALA n 
2 252 GLN n 
2 253 VAL n 
2 254 LEU n 
2 255 LYS n 
2 256 ASP n 
2 257 ASP n 
2 258 THR n 
2 259 THR n 
2 260 THR n 
2 261 LYS n 
2 262 ARG n 
2 263 TRP n 
2 264 LEU n 
2 265 ALA n 
2 266 GLN n 
2 267 LEU n 
2 268 VAL n 
2 269 LYS n 
2 270 ASN n 
2 271 LEU n 
2 272 GLN n 
2 273 GLU n 
3 1   GLY n 
3 2   PRO n 
3 3   HIS n 
3 4   MET n 
3 5   LEU n 
3 6   GLU n 
3 7   VAL n 
3 8   PRO n 
3 9   PRO n 
3 10  GLN n 
3 11  PRO n 
3 12  GLN n 
3 13  TYR n 
3 14  SER n 
3 15  TYR n 
3 16  HIS n 
3 17  ASP n 
3 18  ILE n 
3 19  ASN n 
3 20  VAL n 
3 21  TYR n 
3 22  SER n 
3 23  LEU n 
3 24  ALA n 
3 25  GLY n 
3 26  LEU n 
3 27  ALA n 
3 28  PRO n 
3 29  HIS n 
3 30  ILE n 
3 31  THR n 
3 32  LEU n 
3 33  ASN n 
3 34  PRO n 
3 35  THR n 
3 36  ILE n 
3 37  PRO n 
3 38  LEU n 
3 39  PHE n 
3 40  GLN n 
3 41  ALA n 
3 42  HIS n 
3 43  PRO n 
3 44  GLN n 
3 45  LEU n 
3 46  LYS n 
3 47  GLN n 
3 48  CYS n 
3 49  VAL n 
3 50  ARG n 
3 51  GLN n 
3 52  ALA n 
3 53  ILE n 
3 54  GLU n 
3 55  ARG n 
3 56  ALA n 
3 57  VAL n 
3 58  GLN n 
3 59  GLU n 
3 60  LEU n 
3 61  VAL n 
3 62  HIS n 
3 63  PRO n 
3 64  VAL n 
3 65  VAL n 
3 66  ASP n 
3 67  ARG n 
3 68  SER n 
3 69  ILE n 
3 70  LYS n 
3 71  ILE n 
3 72  ALA n 
3 73  MET n 
3 74  THR n 
3 75  THR n 
3 76  CYS n 
3 77  GLU n 
3 78  GLN n 
3 79  ILE n 
3 80  VAL n 
3 81  ARG n 
3 82  LYS n 
3 83  ASP n 
3 84  PHE n 
3 85  ALA n 
3 86  LEU n 
3 87  ASP n 
3 88  SER n 
3 89  GLU n 
3 90  GLU n 
3 91  SER n 
3 92  ARG n 
3 93  MET n 
3 94  ARG n 
3 95  ILE n 
3 96  ALA n 
3 97  ALA n 
3 98  HIS n 
3 99  HIS n 
3 100 MET n 
3 101 MET n 
3 102 ARG n 
3 103 ASN n 
3 104 LEU n 
3 105 THR n 
3 106 ALA n 
3 107 GLY n 
3 108 MET n 
3 109 ALA n 
3 110 MET n 
3 111 ILE n 
3 112 THR n 
3 113 CYS n 
3 114 ARG n 
3 115 GLU n 
3 116 PRO n 
3 117 LEU n 
3 118 LEU n 
3 119 MET n 
3 120 SER n 
3 121 ILE n 
3 122 SER n 
3 123 THR n 
3 124 ASN n 
3 125 LEU n 
3 126 LYS n 
3 127 ASN n 
3 128 SER n 
3 129 PHE n 
3 130 ALA n 
3 131 SER n 
3 132 ALA n 
3 133 LEU n 
3 134 ARG n 
3 135 THR n 
3 136 ALA n 
3 137 SER n 
3 138 PRO n 
3 139 GLN n 
3 140 GLN n 
3 141 ARG n 
3 142 GLU n 
3 143 MET n 
3 144 MET n 
3 145 ASP n 
3 146 GLN n 
3 147 ALA n 
3 148 ALA n 
3 149 ALA n 
3 150 GLN n 
3 151 LEU n 
3 152 ALA n 
3 153 GLN n 
3 154 ASP n 
3 155 ASN n 
3 156 CYS n 
3 157 GLU n 
3 158 LEU n 
3 159 ALA n 
3 160 CYS n 
3 161 CYS n 
3 162 PHE n 
3 163 ILE n 
3 164 GLN n 
3 165 LYS n 
3 166 THR n 
3 167 ALA n 
3 168 VAL n 
3 169 GLU n 
3 170 LYS n 
3 171 ALA n 
3 172 GLY n 
3 173 PRO n 
3 174 GLU n 
3 175 MET n 
3 176 ASP n 
3 177 LYS n 
3 178 ARG n 
3 179 LEU n 
3 180 ALA n 
3 181 THR n 
3 182 GLU n 
3 183 PHE n 
3 184 GLU n 
3 185 LEU n 
3 186 ARG n 
3 187 LYS n 
3 188 HIS n 
3 189 ALA n 
3 190 ARG n 
3 191 GLN n 
3 192 GLU n 
3 193 GLY n 
3 194 ARG n 
3 195 ARG n 
3 196 TYR n 
3 197 CYS n 
3 198 ASP n 
3 199 PRO n 
3 200 VAL n 
3 201 VAL n 
3 202 LEU n 
3 203 THR n 
3 204 TYR n 
3 205 GLN n 
3 206 ALA n 
3 207 GLU n 
3 208 ARG n 
3 209 MET n 
3 210 PRO n 
3 211 GLU n 
3 212 GLN n 
3 213 ILE n 
3 214 ARG n 
3 215 LEU n 
3 216 LYS n 
3 217 VAL n 
3 218 GLY n 
3 219 GLY n 
3 220 VAL n 
3 221 ASP n 
3 222 PRO n 
3 223 LYS n 
3 224 GLN n 
3 225 LEU n 
3 226 ALA n 
3 227 VAL n 
3 228 TYR n 
3 229 GLU n 
3 230 GLU n 
3 231 PHE n 
3 232 ALA n 
3 233 ARG n 
3 234 ASN n 
3 235 VAL n 
3 236 PRO n 
3 237 GLY n 
3 238 PHE n 
3 239 LEU n 
3 240 PRO n 
3 241 THR n 
3 242 ASN n 
3 243 ASP n 
3 244 LEU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
2 1 sample 'Biological sequence' 1 273 human ? 'CNOT9, RCD1, RQCD1'                   ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? 
? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 244 human ? 'CNOT1, CDC39, KIAA1007, NOT1, AD-005' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? 
? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       19 
_pdbx_entity_src_syn.organism_scientific    'Drosophila melanogaster' 
_pdbx_entity_src_syn.organism_common_name   'Fruit fly' 
_pdbx_entity_src_syn.ncbi_taxonomy_id       7227 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACE non-polymer         . 'ACETYL GROUP'        ? 'C2 H4 O'        44.053  
ALA 'L-peptide linking' y ALANINE               ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE              ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE            ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'       ? 'C4 H7 N O4'     133.103 
BU1 non-polymer         . 1,4-BUTANEDIOL        ? 'C4 H10 O2'      90.121  
CYS 'L-peptide linking' y CYSTEINE              ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE             ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'       ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE               ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE             ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                 ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE            ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE               ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE            ? 'C5 H11 N O2 S'  149.211 
MK8 'L-peptide linking' n 2-methyl-L-norleucine ? 'C7 H15 N O2'    145.199 
NH2 non-polymer         . 'AMINO GROUP'         ? 'H2 N'           16.023  
NLE 'L-peptide linking' n NORLEUCINE            ? 'C6 H13 N O2'    131.173 
PHE 'L-peptide linking' y PHENYLALANINE         ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE               ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE             ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN            ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE              ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ACE 1   16   ?    ?   ?   G . n 
A 1 2   LEU 2   17   17   LEU LEU G . n 
A 1 3   ASP 3   18   18   ASP ASP G . n 
A 1 4   MK8 4   19   19   MK8 MKS G . n 
A 1 5   ASN 5   20   20   ASN ASN G . n 
A 1 6   PHE 6   21   21   PHE PHE G . n 
A 1 7   LYS 7   22   22   LYS LYS G . n 
A 1 8   MK8 8   23   23   MK8 MKS G . n 
A 1 9   NLE 9   24   24   NLE NLE G . n 
A 1 10  GLU 10  25   25   GLU GLU G . n 
A 1 11  GLU 11  26   26   GLU GLU G . n 
A 1 12  HIS 12  27   27   HIS HIS G . n 
A 1 13  LEU 13  28   28   LEU LEU G . n 
A 1 14  ALA 14  29   29   ALA ALA G . n 
A 1 15  LEU 15  30   30   LEU LEU G . n 
A 1 16  NLE 16  31   31   NLE NLE G . n 
A 1 17  VAL 17  32   32   VAL VAL G . n 
A 1 18  GLU 18  33   33   GLU GLU G . n 
A 1 19  NH2 19  34   ?    ?   ?   G . n 
B 1 1   ACE 1   16   16   ACE ACE F . n 
B 1 2   LEU 2   17   17   LEU LEU F . n 
B 1 3   ASP 3   18   18   ASP ASP F . n 
B 1 4   MK8 4   19   19   MK8 MKS F . n 
B 1 5   ASN 5   20   20   ASN ASN F . n 
B 1 6   PHE 6   21   21   PHE PHE F . n 
B 1 7   LYS 7   22   22   LYS LYS F . n 
B 1 8   MK8 8   23   23   MK8 MKS F . n 
B 1 9   NLE 9   24   24   NLE NLE F . n 
B 1 10  GLU 10  25   25   GLU GLU F . n 
B 1 11  GLU 11  26   26   GLU GLU F . n 
B 1 12  HIS 12  27   27   HIS HIS F . n 
B 1 13  LEU 13  28   28   LEU LEU F . n 
B 1 14  ALA 14  29   29   ALA ALA F . n 
B 1 15  LEU 15  30   30   LEU LEU F . n 
B 1 16  NLE 16  31   31   NLE NLE F . n 
B 1 17  VAL 17  32   32   VAL VAL F . n 
B 1 18  GLU 18  33   33   GLU GLU F . n 
B 1 19  NH2 19  34   ?    ?   ?   F . n 
C 2 1   GLY 1   13   13   GLY GLY B . n 
C 2 2   PRO 2   14   14   PRO PRO B . n 
C 2 3   HIS 3   15   15   HIS HIS B . n 
C 2 4   MET 4   16   16   MET MET B . n 
C 2 5   LEU 5   17   17   LEU LEU B . n 
C 2 6   GLU 6   18   18   GLU GLU B . n 
C 2 7   ARG 7   19   19   ARG ARG B . n 
C 2 8   GLU 8   20   20   GLU GLU B . n 
C 2 9   LYS 9   21   21   LYS LYS B . n 
C 2 10  ILE 10  22   22   ILE ILE B . n 
C 2 11  TYR 11  23   23   TYR TYR B . n 
C 2 12  GLN 12  24   24   GLN GLN B . n 
C 2 13  TRP 13  25   25   TRP TRP B . n 
C 2 14  ILE 14  26   26   ILE ILE B . n 
C 2 15  ASN 15  27   27   ASN ASN B . n 
C 2 16  GLU 16  28   28   GLU GLU B . n 
C 2 17  LEU 17  29   29   LEU LEU B . n 
C 2 18  SER 18  30   30   SER SER B . n 
C 2 19  SER 19  31   31   SER SER B . n 
C 2 20  PRO 20  32   32   PRO PRO B . n 
C 2 21  GLU 21  33   33   GLU GLU B . n 
C 2 22  THR 22  34   34   THR THR B . n 
C 2 23  ARG 23  35   35   ARG ARG B . n 
C 2 24  GLU 24  36   36   GLU GLU B . n 
C 2 25  ASN 25  37   37   ASN ASN B . n 
C 2 26  ALA 26  38   38   ALA ALA B . n 
C 2 27  LEU 27  39   39   LEU LEU B . n 
C 2 28  LEU 28  40   40   LEU LEU B . n 
C 2 29  GLU 29  41   41   GLU GLU B . n 
C 2 30  LEU 30  42   42   LEU LEU B . n 
C 2 31  SER 31  43   43   SER SER B . n 
C 2 32  LYS 32  44   44   LYS LYS B . n 
C 2 33  LYS 33  45   45   LYS LYS B . n 
C 2 34  ARG 34  46   46   ARG ARG B . n 
C 2 35  GLU 35  47   47   GLU GLU B . n 
C 2 36  SER 36  48   48   SER SER B . n 
C 2 37  VAL 37  49   49   VAL VAL B . n 
C 2 38  PRO 38  50   50   PRO PRO B . n 
C 2 39  ASP 39  51   51   ASP ASP B . n 
C 2 40  LEU 40  52   52   LEU LEU B . n 
C 2 41  ALA 41  53   53   ALA ALA B . n 
C 2 42  PRO 42  54   54   PRO PRO B . n 
C 2 43  MET 43  55   55   MET MET B . n 
C 2 44  LEU 44  56   56   LEU LEU B . n 
C 2 45  TRP 45  57   57   TRP TRP B . n 
C 2 46  HIS 46  58   58   HIS HIS B . n 
C 2 47  SER 47  59   59   SER SER B . n 
C 2 48  PHE 48  60   60   PHE PHE B . n 
C 2 49  GLY 49  61   61   GLY GLY B . n 
C 2 50  THR 50  62   62   THR THR B . n 
C 2 51  ILE 51  63   63   ILE ILE B . n 
C 2 52  ALA 52  64   64   ALA ALA B . n 
C 2 53  ALA 53  65   65   ALA ALA B . n 
C 2 54  LEU 54  66   66   LEU LEU B . n 
C 2 55  LEU 55  67   67   LEU LEU B . n 
C 2 56  GLN 56  68   68   GLN GLN B . n 
C 2 57  GLU 57  69   69   GLU GLU B . n 
C 2 58  ILE 58  70   70   ILE ILE B . n 
C 2 59  VAL 59  71   71   VAL VAL B . n 
C 2 60  ASN 60  72   72   ASN ASN B . n 
C 2 61  ILE 61  73   73   ILE ILE B . n 
C 2 62  TYR 62  74   74   TYR TYR B . n 
C 2 63  PRO 63  75   75   PRO PRO B . n 
C 2 64  SER 64  76   76   SER SER B . n 
C 2 65  ILE 65  77   77   ILE ILE B . n 
C 2 66  ASN 66  78   78   ASN ASN B . n 
C 2 67  PRO 67  79   79   PRO PRO B . n 
C 2 68  PRO 68  80   80   PRO PRO B . n 
C 2 69  THR 69  81   81   THR THR B . n 
C 2 70  LEU 70  82   82   LEU LEU B . n 
C 2 71  THR 71  83   83   THR THR B . n 
C 2 72  ALA 72  84   84   ALA ALA B . n 
C 2 73  HIS 73  85   85   HIS HIS B . n 
C 2 74  GLN 74  86   86   GLN GLN B . n 
C 2 75  SER 75  87   87   SER SER B . n 
C 2 76  ASN 76  88   88   ASN ASN B . n 
C 2 77  ARG 77  89   89   ARG ARG B . n 
C 2 78  VAL 78  90   90   VAL VAL B . n 
C 2 79  CYS 79  91   91   CYS CYS B . n 
C 2 80  ASN 80  92   92   ASN ASN B . n 
C 2 81  ALA 81  93   93   ALA ALA B . n 
C 2 82  LEU 82  94   94   LEU LEU B . n 
C 2 83  ALA 83  95   95   ALA ALA B . n 
C 2 84  LEU 84  96   96   LEU LEU B . n 
C 2 85  LEU 85  97   97   LEU LEU B . n 
C 2 86  GLN 86  98   98   GLN GLN B . n 
C 2 87  CYS 87  99   99   CYS CYS B . n 
C 2 88  VAL 88  100  100  VAL VAL B . n 
C 2 89  ALA 89  101  101  ALA ALA B . n 
C 2 90  SER 90  102  102  SER SER B . n 
C 2 91  HIS 91  103  103  HIS HIS B . n 
C 2 92  PRO 92  104  104  PRO PRO B . n 
C 2 93  GLU 93  105  105  GLU GLU B . n 
C 2 94  THR 94  106  106  THR THR B . n 
C 2 95  ARG 95  107  107  ARG ARG B . n 
C 2 96  SER 96  108  108  SER SER B . n 
C 2 97  ALA 97  109  109  ALA ALA B . n 
C 2 98  PHE 98  110  110  PHE PHE B . n 
C 2 99  LEU 99  111  111  LEU LEU B . n 
C 2 100 ALA 100 112  112  ALA ALA B . n 
C 2 101 ALA 101 113  113  ALA ALA B . n 
C 2 102 HIS 102 114  114  HIS HIS B . n 
C 2 103 ILE 103 115  115  ILE ILE B . n 
C 2 104 PRO 104 116  116  PRO PRO B . n 
C 2 105 LEU 105 117  117  LEU LEU B . n 
C 2 106 PHE 106 118  118  PHE PHE B . n 
C 2 107 LEU 107 119  119  LEU LEU B . n 
C 2 108 TYR 108 120  120  TYR TYR B . n 
C 2 109 PRO 109 121  121  PRO PRO B . n 
C 2 110 PHE 110 122  122  PHE PHE B . n 
C 2 111 LEU 111 123  123  LEU LEU B . n 
C 2 112 HIS 112 124  124  HIS HIS B . n 
C 2 113 THR 113 125  125  THR THR B . n 
C 2 114 VAL 114 126  126  VAL VAL B . n 
C 2 115 SER 115 127  127  SER SER B . n 
C 2 116 LYS 116 128  128  LYS LYS B . n 
C 2 117 THR 117 129  129  THR THR B . n 
C 2 118 ARG 118 130  130  ARG ARG B . n 
C 2 119 PRO 119 131  131  PRO PRO B . n 
C 2 120 PHE 120 132  132  PHE PHE B . n 
C 2 121 GLU 121 133  133  GLU GLU B . n 
C 2 122 TYR 122 134  134  TYR TYR B . n 
C 2 123 LEU 123 135  135  LEU LEU B . n 
C 2 124 ARG 124 136  136  ARG ARG B . n 
C 2 125 LEU 125 137  137  LEU LEU B . n 
C 2 126 THR 126 138  138  THR THR B . n 
C 2 127 SER 127 139  139  SER SER B . n 
C 2 128 LEU 128 140  140  LEU LEU B . n 
C 2 129 GLY 129 141  141  GLY GLY B . n 
C 2 130 VAL 130 142  142  VAL VAL B . n 
C 2 131 ILE 131 143  143  ILE ILE B . n 
C 2 132 GLY 132 144  144  GLY GLY B . n 
C 2 133 ALA 133 145  145  ALA ALA B . n 
C 2 134 LEU 134 146  146  LEU LEU B . n 
C 2 135 VAL 135 147  147  VAL VAL B . n 
C 2 136 LYS 136 148  148  LYS LYS B . n 
C 2 137 THR 137 149  149  THR THR B . n 
C 2 138 ASP 138 150  150  ASP ASP B . n 
C 2 139 GLU 139 151  151  GLU GLU B . n 
C 2 140 GLN 140 152  152  GLN GLN B . n 
C 2 141 GLU 141 153  153  GLU GLU B . n 
C 2 142 VAL 142 154  154  VAL VAL B . n 
C 2 143 ILE 143 155  155  ILE ILE B . n 
C 2 144 ASN 144 156  156  ASN ASN B . n 
C 2 145 PHE 145 157  157  PHE PHE B . n 
C 2 146 LEU 146 158  158  LEU LEU B . n 
C 2 147 LEU 147 159  159  LEU LEU B . n 
C 2 148 THR 148 160  160  THR THR B . n 
C 2 149 THR 149 161  161  THR THR B . n 
C 2 150 GLU 150 162  162  GLU GLU B . n 
C 2 151 ILE 151 163  163  ILE ILE B . n 
C 2 152 ILE 152 164  164  ILE ILE B . n 
C 2 153 PRO 153 165  165  PRO PRO B . n 
C 2 154 LEU 154 166  166  LEU LEU B . n 
C 2 155 CYS 155 167  167  CYS CYS B . n 
C 2 156 LEU 156 168  168  LEU LEU B . n 
C 2 157 ARG 157 169  169  ARG ARG B . n 
C 2 158 ILE 158 170  170  ILE ILE B . n 
C 2 159 MET 159 171  171  MET MET B . n 
C 2 160 GLU 160 172  172  GLU GLU B . n 
C 2 161 SER 161 173  173  SER SER B . n 
C 2 162 GLY 162 174  174  GLY GLY B . n 
C 2 163 SER 163 175  175  SER SER B . n 
C 2 164 GLU 164 176  176  GLU GLU B . n 
C 2 165 LEU 165 177  177  LEU LEU B . n 
C 2 166 SER 166 178  178  SER SER B . n 
C 2 167 LYS 167 179  179  LYS LYS B . n 
C 2 168 THR 168 180  180  THR THR B . n 
C 2 169 VAL 169 181  181  VAL VAL B . n 
C 2 170 ALA 170 182  182  ALA ALA B . n 
C 2 171 THR 171 183  183  THR THR B . n 
C 2 172 PHE 172 184  184  PHE PHE B . n 
C 2 173 ILE 173 185  185  ILE ILE B . n 
C 2 174 LEU 174 186  186  LEU LEU B . n 
C 2 175 GLN 175 187  187  GLN GLN B . n 
C 2 176 LYS 176 188  188  LYS LYS B . n 
C 2 177 ILE 177 189  189  ILE ILE B . n 
C 2 178 LEU 178 190  190  LEU LEU B . n 
C 2 179 LEU 179 191  191  LEU LEU B . n 
C 2 180 ASP 180 192  192  ASP ASP B . n 
C 2 181 ASP 181 193  193  ASP ASP B . n 
C 2 182 THR 182 194  194  THR THR B . n 
C 2 183 GLY 183 195  195  GLY GLY B . n 
C 2 184 LEU 184 196  196  LEU LEU B . n 
C 2 185 ALA 185 197  197  ALA ALA B . n 
C 2 186 TYR 186 198  198  TYR TYR B . n 
C 2 187 ILE 187 199  199  ILE ILE B . n 
C 2 188 CYS 188 200  200  CYS CYS B . n 
C 2 189 GLN 189 201  201  GLN GLN B . n 
C 2 190 THR 190 202  202  THR THR B . n 
C 2 191 TYR 191 203  203  TYR TYR B . n 
C 2 192 GLU 192 204  204  GLU GLU B . n 
C 2 193 ARG 193 205  205  ARG ARG B . n 
C 2 194 PHE 194 206  206  PHE PHE B . n 
C 2 195 SER 195 207  207  SER SER B . n 
C 2 196 HIS 196 208  208  HIS HIS B . n 
C 2 197 VAL 197 209  209  VAL VAL B . n 
C 2 198 ALA 198 210  210  ALA ALA B . n 
C 2 199 MET 199 211  211  MET MET B . n 
C 2 200 ILE 200 212  212  ILE ILE B . n 
C 2 201 LEU 201 213  213  LEU LEU B . n 
C 2 202 GLY 202 214  214  GLY GLY B . n 
C 2 203 LYS 203 215  215  LYS LYS B . n 
C 2 204 MET 204 216  216  MET MET B . n 
C 2 205 VAL 205 217  217  VAL VAL B . n 
C 2 206 LEU 206 218  218  LEU LEU B . n 
C 2 207 GLN 207 219  219  GLN GLN B . n 
C 2 208 LEU 208 220  220  LEU LEU B . n 
C 2 209 SER 209 221  221  SER SER B . n 
C 2 210 LYS 210 222  222  LYS LYS B . n 
C 2 211 GLU 211 223  223  GLU GLU B . n 
C 2 212 PRO 212 224  224  PRO PRO B . n 
C 2 213 SER 213 225  225  SER SER B . n 
C 2 214 ALA 214 226  226  ALA ALA B . n 
C 2 215 ARG 215 227  227  ARG ARG B . n 
C 2 216 LEU 216 228  228  LEU LEU B . n 
C 2 217 LEU 217 229  229  LEU LEU B . n 
C 2 218 LYS 218 230  230  LYS LYS B . n 
C 2 219 HIS 219 231  231  HIS HIS B . n 
C 2 220 VAL 220 232  232  VAL VAL B . n 
C 2 221 VAL 221 233  233  VAL VAL B . n 
C 2 222 ARG 222 234  234  ARG ARG B . n 
C 2 223 CYS 223 235  235  CYS CYS B . n 
C 2 224 TYR 224 236  236  TYR TYR B . n 
C 2 225 LEU 225 237  237  LEU LEU B . n 
C 2 226 ARG 226 238  238  ARG ARG B . n 
C 2 227 LEU 227 239  239  LEU LEU B . n 
C 2 228 SER 228 240  240  SER SER B . n 
C 2 229 ASP 229 241  241  ASP ASP B . n 
C 2 230 ASN 230 242  242  ASN ASN B . n 
C 2 231 PRO 231 243  243  PRO PRO B . n 
C 2 232 ARG 232 244  244  ARG ARG B . n 
C 2 233 ALA 233 245  245  ALA ALA B . n 
C 2 234 ARG 234 246  246  ARG ARG B . n 
C 2 235 GLU 235 247  247  GLU GLU B . n 
C 2 236 ALA 236 248  248  ALA ALA B . n 
C 2 237 LEU 237 249  249  LEU LEU B . n 
C 2 238 ARG 238 250  250  ARG ARG B . n 
C 2 239 GLN 239 251  251  GLN GLN B . n 
C 2 240 CYS 240 252  252  CYS CYS B . n 
C 2 241 LEU 241 253  253  LEU LEU B . n 
C 2 242 PRO 242 254  254  PRO PRO B . n 
C 2 243 ASP 243 255  255  ASP ASP B . n 
C 2 244 GLN 244 256  256  GLN GLN B . n 
C 2 245 LEU 245 257  257  LEU LEU B . n 
C 2 246 LYS 246 258  258  LYS LYS B . n 
C 2 247 ASP 247 259  259  ASP ASP B . n 
C 2 248 THR 248 260  260  THR THR B . n 
C 2 249 THR 249 261  261  THR THR B . n 
C 2 250 PHE 250 262  262  PHE PHE B . n 
C 2 251 ALA 251 263  263  ALA ALA B . n 
C 2 252 GLN 252 264  264  GLN GLN B . n 
C 2 253 VAL 253 265  265  VAL VAL B . n 
C 2 254 LEU 254 266  266  LEU LEU B . n 
C 2 255 LYS 255 267  267  LYS LYS B . n 
C 2 256 ASP 256 268  268  ASP ASP B . n 
C 2 257 ASP 257 269  269  ASP ASP B . n 
C 2 258 THR 258 270  270  THR THR B . n 
C 2 259 THR 259 271  271  THR THR B . n 
C 2 260 THR 260 272  272  THR THR B . n 
C 2 261 LYS 261 273  273  LYS LYS B . n 
C 2 262 ARG 262 274  274  ARG ARG B . n 
C 2 263 TRP 263 275  275  TRP TRP B . n 
C 2 264 LEU 264 276  276  LEU LEU B . n 
C 2 265 ALA 265 277  277  ALA ALA B . n 
C 2 266 GLN 266 278  278  GLN GLN B . n 
C 2 267 LEU 267 279  279  LEU LEU B . n 
C 2 268 VAL 268 280  280  VAL VAL B . n 
C 2 269 LYS 269 281  281  LYS LYS B . n 
C 2 270 ASN 270 282  282  ASN ASN B . n 
C 2 271 LEU 271 283  283  LEU LEU B . n 
C 2 272 GLN 272 284  284  GLN GLN B . n 
C 2 273 GLU 273 285  285  GLU GLU B . n 
D 3 1   GLY 1   1345 ?    ?   ?   A . n 
D 3 2   PRO 2   1346 ?    ?   ?   A . n 
D 3 3   HIS 3   1347 ?    ?   ?   A . n 
D 3 4   MET 4   1348 ?    ?   ?   A . n 
D 3 5   LEU 5   1349 ?    ?   ?   A . n 
D 3 6   GLU 6   1350 ?    ?   ?   A . n 
D 3 7   VAL 7   1351 ?    ?   ?   A . n 
D 3 8   PRO 8   1352 ?    ?   ?   A . n 
D 3 9   PRO 9   1353 ?    ?   ?   A . n 
D 3 10  GLN 10  1354 1354 GLN GLN A . n 
D 3 11  PRO 11  1355 1355 PRO PRO A . n 
D 3 12  GLN 12  1356 1356 GLN GLN A . n 
D 3 13  TYR 13  1357 1357 TYR TYR A . n 
D 3 14  SER 14  1358 1358 SER SER A . n 
D 3 15  TYR 15  1359 1359 TYR TYR A . n 
D 3 16  HIS 16  1360 1360 HIS HIS A . n 
D 3 17  ASP 17  1361 1361 ASP ASP A . n 
D 3 18  ILE 18  1362 1362 ILE ILE A . n 
D 3 19  ASN 19  1363 1363 ASN ASN A . n 
D 3 20  VAL 20  1364 1364 VAL VAL A . n 
D 3 21  TYR 21  1365 1365 TYR TYR A . n 
D 3 22  SER 22  1366 1366 SER SER A . n 
D 3 23  LEU 23  1367 1367 LEU LEU A . n 
D 3 24  ALA 24  1368 1368 ALA ALA A . n 
D 3 25  GLY 25  1369 1369 GLY GLY A . n 
D 3 26  LEU 26  1370 1370 LEU LEU A . n 
D 3 27  ALA 27  1371 1371 ALA ALA A . n 
D 3 28  PRO 28  1372 1372 PRO PRO A . n 
D 3 29  HIS 29  1373 1373 HIS HIS A . n 
D 3 30  ILE 30  1374 1374 ILE ILE A . n 
D 3 31  THR 31  1375 1375 THR THR A . n 
D 3 32  LEU 32  1376 1376 LEU LEU A . n 
D 3 33  ASN 33  1377 1377 ASN ASN A . n 
D 3 34  PRO 34  1378 1378 PRO PRO A . n 
D 3 35  THR 35  1379 1379 THR THR A . n 
D 3 36  ILE 36  1380 1380 ILE ILE A . n 
D 3 37  PRO 37  1381 1381 PRO PRO A . n 
D 3 38  LEU 38  1382 1382 LEU LEU A . n 
D 3 39  PHE 39  1383 1383 PHE PHE A . n 
D 3 40  GLN 40  1384 1384 GLN GLN A . n 
D 3 41  ALA 41  1385 1385 ALA ALA A . n 
D 3 42  HIS 42  1386 1386 HIS HIS A . n 
D 3 43  PRO 43  1387 1387 PRO PRO A . n 
D 3 44  GLN 44  1388 1388 GLN GLN A . n 
D 3 45  LEU 45  1389 1389 LEU LEU A . n 
D 3 46  LYS 46  1390 1390 LYS LYS A . n 
D 3 47  GLN 47  1391 1391 GLN GLN A . n 
D 3 48  CYS 48  1392 1392 CYS CYS A . n 
D 3 49  VAL 49  1393 1393 VAL VAL A . n 
D 3 50  ARG 50  1394 1394 ARG ARG A . n 
D 3 51  GLN 51  1395 1395 GLN GLN A . n 
D 3 52  ALA 52  1396 1396 ALA ALA A . n 
D 3 53  ILE 53  1397 1397 ILE ILE A . n 
D 3 54  GLU 54  1398 1398 GLU GLU A . n 
D 3 55  ARG 55  1399 1399 ARG ARG A . n 
D 3 56  ALA 56  1400 1400 ALA ALA A . n 
D 3 57  VAL 57  1401 1401 VAL VAL A . n 
D 3 58  GLN 58  1402 1402 GLN GLN A . n 
D 3 59  GLU 59  1403 1403 GLU GLU A . n 
D 3 60  LEU 60  1404 1404 LEU LEU A . n 
D 3 61  VAL 61  1405 1405 VAL VAL A . n 
D 3 62  HIS 62  1406 1406 HIS HIS A . n 
D 3 63  PRO 63  1407 1407 PRO PRO A . n 
D 3 64  VAL 64  1408 1408 VAL VAL A . n 
D 3 65  VAL 65  1409 1409 VAL VAL A . n 
D 3 66  ASP 66  1410 1410 ASP ASP A . n 
D 3 67  ARG 67  1411 1411 ARG ARG A . n 
D 3 68  SER 68  1412 1412 SER SER A . n 
D 3 69  ILE 69  1413 1413 ILE ILE A . n 
D 3 70  LYS 70  1414 1414 LYS LYS A . n 
D 3 71  ILE 71  1415 1415 ILE ILE A . n 
D 3 72  ALA 72  1416 1416 ALA ALA A . n 
D 3 73  MET 73  1417 1417 MET MET A . n 
D 3 74  THR 74  1418 1418 THR THR A . n 
D 3 75  THR 75  1419 1419 THR THR A . n 
D 3 76  CYS 76  1420 1420 CYS CYS A . n 
D 3 77  GLU 77  1421 1421 GLU GLU A . n 
D 3 78  GLN 78  1422 1422 GLN GLN A . n 
D 3 79  ILE 79  1423 1423 ILE ILE A . n 
D 3 80  VAL 80  1424 1424 VAL VAL A . n 
D 3 81  ARG 81  1425 1425 ARG ARG A . n 
D 3 82  LYS 82  1426 1426 LYS LYS A . n 
D 3 83  ASP 83  1427 1427 ASP ASP A . n 
D 3 84  PHE 84  1428 1428 PHE PHE A . n 
D 3 85  ALA 85  1429 1429 ALA ALA A . n 
D 3 86  LEU 86  1430 1430 LEU LEU A . n 
D 3 87  ASP 87  1431 1431 ASP ASP A . n 
D 3 88  SER 88  1432 1432 SER SER A . n 
D 3 89  GLU 89  1433 1433 GLU GLU A . n 
D 3 90  GLU 90  1434 1434 GLU GLU A . n 
D 3 91  SER 91  1435 1435 SER SER A . n 
D 3 92  ARG 92  1436 1436 ARG ARG A . n 
D 3 93  MET 93  1437 1437 MET MET A . n 
D 3 94  ARG 94  1438 1438 ARG ARG A . n 
D 3 95  ILE 95  1439 1439 ILE ILE A . n 
D 3 96  ALA 96  1440 1440 ALA ALA A . n 
D 3 97  ALA 97  1441 1441 ALA ALA A . n 
D 3 98  HIS 98  1442 1442 HIS HIS A . n 
D 3 99  HIS 99  1443 1443 HIS HIS A . n 
D 3 100 MET 100 1444 1444 MET MET A . n 
D 3 101 MET 101 1445 1445 MET MET A . n 
D 3 102 ARG 102 1446 1446 ARG ARG A . n 
D 3 103 ASN 103 1447 1447 ASN ASN A . n 
D 3 104 LEU 104 1448 1448 LEU LEU A . n 
D 3 105 THR 105 1449 1449 THR THR A . n 
D 3 106 ALA 106 1450 1450 ALA ALA A . n 
D 3 107 GLY 107 1451 1451 GLY GLY A . n 
D 3 108 MET 108 1452 1452 MET MET A . n 
D 3 109 ALA 109 1453 1453 ALA ALA A . n 
D 3 110 MET 110 1454 1454 MET MET A . n 
D 3 111 ILE 111 1455 1455 ILE ILE A . n 
D 3 112 THR 112 1456 1456 THR THR A . n 
D 3 113 CYS 113 1457 1457 CYS CYS A . n 
D 3 114 ARG 114 1458 1458 ARG ARG A . n 
D 3 115 GLU 115 1459 1459 GLU GLU A . n 
D 3 116 PRO 116 1460 1460 PRO PRO A . n 
D 3 117 LEU 117 1461 1461 LEU LEU A . n 
D 3 118 LEU 118 1462 1462 LEU LEU A . n 
D 3 119 MET 119 1463 1463 MET MET A . n 
D 3 120 SER 120 1464 1464 SER SER A . n 
D 3 121 ILE 121 1465 1465 ILE ILE A . n 
D 3 122 SER 122 1466 1466 SER SER A . n 
D 3 123 THR 123 1467 1467 THR THR A . n 
D 3 124 ASN 124 1468 1468 ASN ASN A . n 
D 3 125 LEU 125 1469 1469 LEU LEU A . n 
D 3 126 LYS 126 1470 1470 LYS LYS A . n 
D 3 127 ASN 127 1471 1471 ASN ASN A . n 
D 3 128 SER 128 1472 1472 SER SER A . n 
D 3 129 PHE 129 1473 1473 PHE PHE A . n 
D 3 130 ALA 130 1474 1474 ALA ALA A . n 
D 3 131 SER 131 1475 1475 SER SER A . n 
D 3 132 ALA 132 1476 1476 ALA ALA A . n 
D 3 133 LEU 133 1477 1477 LEU LEU A . n 
D 3 134 ARG 134 1478 1478 ARG ARG A . n 
D 3 135 THR 135 1479 1479 THR THR A . n 
D 3 136 ALA 136 1480 1480 ALA ALA A . n 
D 3 137 SER 137 1481 1481 SER SER A . n 
D 3 138 PRO 138 1482 1482 PRO PRO A . n 
D 3 139 GLN 139 1483 1483 GLN GLN A . n 
D 3 140 GLN 140 1484 1484 GLN GLN A . n 
D 3 141 ARG 141 1485 1485 ARG ARG A . n 
D 3 142 GLU 142 1486 1486 GLU GLU A . n 
D 3 143 MET 143 1487 1487 MET MET A . n 
D 3 144 MET 144 1488 1488 MET MET A . n 
D 3 145 ASP 145 1489 1489 ASP ASP A . n 
D 3 146 GLN 146 1490 1490 GLN GLN A . n 
D 3 147 ALA 147 1491 1491 ALA ALA A . n 
D 3 148 ALA 148 1492 1492 ALA ALA A . n 
D 3 149 ALA 149 1493 1493 ALA ALA A . n 
D 3 150 GLN 150 1494 1494 GLN GLN A . n 
D 3 151 LEU 151 1495 1495 LEU LEU A . n 
D 3 152 ALA 152 1496 1496 ALA ALA A . n 
D 3 153 GLN 153 1497 1497 GLN GLN A . n 
D 3 154 ASP 154 1498 1498 ASP ASP A . n 
D 3 155 ASN 155 1499 1499 ASN ASN A . n 
D 3 156 CYS 156 1500 1500 CYS CYS A . n 
D 3 157 GLU 157 1501 1501 GLU GLU A . n 
D 3 158 LEU 158 1502 1502 LEU LEU A . n 
D 3 159 ALA 159 1503 1503 ALA ALA A . n 
D 3 160 CYS 160 1504 1504 CYS CYS A . n 
D 3 161 CYS 161 1505 1505 CYS CYS A . n 
D 3 162 PHE 162 1506 1506 PHE PHE A . n 
D 3 163 ILE 163 1507 1507 ILE ILE A . n 
D 3 164 GLN 164 1508 1508 GLN GLN A . n 
D 3 165 LYS 165 1509 1509 LYS LYS A . n 
D 3 166 THR 166 1510 1510 THR THR A . n 
D 3 167 ALA 167 1511 1511 ALA ALA A . n 
D 3 168 VAL 168 1512 1512 VAL VAL A . n 
D 3 169 GLU 169 1513 1513 GLU GLU A . n 
D 3 170 LYS 170 1514 1514 LYS LYS A . n 
D 3 171 ALA 171 1515 1515 ALA ALA A . n 
D 3 172 GLY 172 1516 1516 GLY GLY A . n 
D 3 173 PRO 173 1517 1517 PRO PRO A . n 
D 3 174 GLU 174 1518 1518 GLU GLU A . n 
D 3 175 MET 175 1519 1519 MET MET A . n 
D 3 176 ASP 176 1520 1520 ASP ASP A . n 
D 3 177 LYS 177 1521 1521 LYS LYS A . n 
D 3 178 ARG 178 1522 1522 ARG ARG A . n 
D 3 179 LEU 179 1523 1523 LEU LEU A . n 
D 3 180 ALA 180 1524 1524 ALA ALA A . n 
D 3 181 THR 181 1525 1525 THR THR A . n 
D 3 182 GLU 182 1526 1526 GLU GLU A . n 
D 3 183 PHE 183 1527 1527 PHE PHE A . n 
D 3 184 GLU 184 1528 1528 GLU GLU A . n 
D 3 185 LEU 185 1529 1529 LEU LEU A . n 
D 3 186 ARG 186 1530 1530 ARG ARG A . n 
D 3 187 LYS 187 1531 1531 LYS LYS A . n 
D 3 188 HIS 188 1532 1532 HIS HIS A . n 
D 3 189 ALA 189 1533 1533 ALA ALA A . n 
D 3 190 ARG 190 1534 1534 ARG ARG A . n 
D 3 191 GLN 191 1535 1535 GLN GLN A . n 
D 3 192 GLU 192 1536 1536 GLU GLU A . n 
D 3 193 GLY 193 1537 1537 GLY GLY A . n 
D 3 194 ARG 194 1538 1538 ARG ARG A . n 
D 3 195 ARG 195 1539 1539 ARG ARG A . n 
D 3 196 TYR 196 1540 1540 TYR TYR A . n 
D 3 197 CYS 197 1541 1541 CYS CYS A . n 
D 3 198 ASP 198 1542 1542 ASP ASP A . n 
D 3 199 PRO 199 1543 1543 PRO PRO A . n 
D 3 200 VAL 200 1544 1544 VAL VAL A . n 
D 3 201 VAL 201 1545 1545 VAL VAL A . n 
D 3 202 LEU 202 1546 1546 LEU LEU A . n 
D 3 203 THR 203 1547 1547 THR THR A . n 
D 3 204 TYR 204 1548 1548 TYR TYR A . n 
D 3 205 GLN 205 1549 1549 GLN GLN A . n 
D 3 206 ALA 206 1550 1550 ALA ALA A . n 
D 3 207 GLU 207 1551 1551 GLU GLU A . n 
D 3 208 ARG 208 1552 1552 ARG ARG A . n 
D 3 209 MET 209 1553 1553 MET MET A . n 
D 3 210 PRO 210 1554 1554 PRO PRO A . n 
D 3 211 GLU 211 1555 1555 GLU GLU A . n 
D 3 212 GLN 212 1556 1556 GLN GLN A . n 
D 3 213 ILE 213 1557 1557 ILE ILE A . n 
D 3 214 ARG 214 1558 1558 ARG ARG A . n 
D 3 215 LEU 215 1559 1559 LEU LEU A . n 
D 3 216 LYS 216 1560 1560 LYS LYS A . n 
D 3 217 VAL 217 1561 1561 VAL VAL A . n 
D 3 218 GLY 218 1562 1562 GLY GLY A . n 
D 3 219 GLY 219 1563 1563 GLY GLY A . n 
D 3 220 VAL 220 1564 1564 VAL VAL A . n 
D 3 221 ASP 221 1565 1565 ASP ASP A . n 
D 3 222 PRO 222 1566 1566 PRO PRO A . n 
D 3 223 LYS 223 1567 1567 LYS LYS A . n 
D 3 224 GLN 224 1568 1568 GLN GLN A . n 
D 3 225 LEU 225 1569 1569 LEU LEU A . n 
D 3 226 ALA 226 1570 1570 ALA ALA A . n 
D 3 227 VAL 227 1571 1571 VAL VAL A . n 
D 3 228 TYR 228 1572 1572 TYR TYR A . n 
D 3 229 GLU 229 1573 1573 GLU GLU A . n 
D 3 230 GLU 230 1574 1574 GLU GLU A . n 
D 3 231 PHE 231 1575 1575 PHE PHE A . n 
D 3 232 ALA 232 1576 1576 ALA ALA A . n 
D 3 233 ARG 233 1577 1577 ARG ARG A . n 
D 3 234 ASN 234 1578 1578 ASN ASN A . n 
D 3 235 VAL 235 1579 1579 VAL VAL A . n 
D 3 236 PRO 236 1580 1580 PRO PRO A . n 
D 3 237 GLY 237 1581 1581 GLY GLY A . n 
D 3 238 PHE 238 1582 1582 PHE PHE A . n 
D 3 239 LEU 239 1583 1583 LEU LEU A . n 
D 3 240 PRO 240 1584 1584 PRO PRO A . n 
D 3 241 THR 241 1585 1585 THR THR A . n 
D 3 242 ASN 242 1586 1586 ASN ASN A . n 
D 3 243 ASP 243 1587 1587 ASP ASP A . n 
D 3 244 LEU 244 1588 1588 LEU LEU A . n 
E 2 1   GLY 1   13   13   GLY GLY C . n 
E 2 2   PRO 2   14   14   PRO PRO C . n 
E 2 3   HIS 3   15   15   HIS HIS C . n 
E 2 4   MET 4   16   16   MET MET C . n 
E 2 5   LEU 5   17   17   LEU LEU C . n 
E 2 6   GLU 6   18   18   GLU GLU C . n 
E 2 7   ARG 7   19   19   ARG ARG C . n 
E 2 8   GLU 8   20   20   GLU GLU C . n 
E 2 9   LYS 9   21   21   LYS LYS C . n 
E 2 10  ILE 10  22   22   ILE ILE C . n 
E 2 11  TYR 11  23   23   TYR TYR C . n 
E 2 12  GLN 12  24   24   GLN GLN C . n 
E 2 13  TRP 13  25   25   TRP TRP C . n 
E 2 14  ILE 14  26   26   ILE ILE C . n 
E 2 15  ASN 15  27   27   ASN ASN C . n 
E 2 16  GLU 16  28   28   GLU GLU C . n 
E 2 17  LEU 17  29   29   LEU LEU C . n 
E 2 18  SER 18  30   30   SER SER C . n 
E 2 19  SER 19  31   31   SER SER C . n 
E 2 20  PRO 20  32   32   PRO PRO C . n 
E 2 21  GLU 21  33   33   GLU GLU C . n 
E 2 22  THR 22  34   34   THR THR C . n 
E 2 23  ARG 23  35   35   ARG ARG C . n 
E 2 24  GLU 24  36   36   GLU GLU C . n 
E 2 25  ASN 25  37   37   ASN ASN C . n 
E 2 26  ALA 26  38   38   ALA ALA C . n 
E 2 27  LEU 27  39   39   LEU LEU C . n 
E 2 28  LEU 28  40   40   LEU LEU C . n 
E 2 29  GLU 29  41   41   GLU GLU C . n 
E 2 30  LEU 30  42   42   LEU LEU C . n 
E 2 31  SER 31  43   43   SER SER C . n 
E 2 32  LYS 32  44   44   LYS LYS C . n 
E 2 33  LYS 33  45   45   LYS LYS C . n 
E 2 34  ARG 34  46   46   ARG ARG C . n 
E 2 35  GLU 35  47   47   GLU GLU C . n 
E 2 36  SER 36  48   48   SER SER C . n 
E 2 37  VAL 37  49   49   VAL VAL C . n 
E 2 38  PRO 38  50   50   PRO PRO C . n 
E 2 39  ASP 39  51   51   ASP ASP C . n 
E 2 40  LEU 40  52   52   LEU LEU C . n 
E 2 41  ALA 41  53   53   ALA ALA C . n 
E 2 42  PRO 42  54   54   PRO PRO C . n 
E 2 43  MET 43  55   55   MET MET C . n 
E 2 44  LEU 44  56   56   LEU LEU C . n 
E 2 45  TRP 45  57   57   TRP TRP C . n 
E 2 46  HIS 46  58   58   HIS HIS C . n 
E 2 47  SER 47  59   59   SER SER C . n 
E 2 48  PHE 48  60   60   PHE PHE C . n 
E 2 49  GLY 49  61   61   GLY GLY C . n 
E 2 50  THR 50  62   62   THR THR C . n 
E 2 51  ILE 51  63   63   ILE ILE C . n 
E 2 52  ALA 52  64   64   ALA ALA C . n 
E 2 53  ALA 53  65   65   ALA ALA C . n 
E 2 54  LEU 54  66   66   LEU LEU C . n 
E 2 55  LEU 55  67   67   LEU LEU C . n 
E 2 56  GLN 56  68   68   GLN GLN C . n 
E 2 57  GLU 57  69   69   GLU GLU C . n 
E 2 58  ILE 58  70   70   ILE ILE C . n 
E 2 59  VAL 59  71   71   VAL VAL C . n 
E 2 60  ASN 60  72   72   ASN ASN C . n 
E 2 61  ILE 61  73   73   ILE ILE C . n 
E 2 62  TYR 62  74   74   TYR TYR C . n 
E 2 63  PRO 63  75   75   PRO PRO C . n 
E 2 64  SER 64  76   76   SER SER C . n 
E 2 65  ILE 65  77   77   ILE ILE C . n 
E 2 66  ASN 66  78   78   ASN ASN C . n 
E 2 67  PRO 67  79   79   PRO PRO C . n 
E 2 68  PRO 68  80   80   PRO PRO C . n 
E 2 69  THR 69  81   81   THR THR C . n 
E 2 70  LEU 70  82   82   LEU LEU C . n 
E 2 71  THR 71  83   83   THR THR C . n 
E 2 72  ALA 72  84   84   ALA ALA C . n 
E 2 73  HIS 73  85   85   HIS HIS C . n 
E 2 74  GLN 74  86   86   GLN GLN C . n 
E 2 75  SER 75  87   87   SER SER C . n 
E 2 76  ASN 76  88   88   ASN ASN C . n 
E 2 77  ARG 77  89   89   ARG ARG C . n 
E 2 78  VAL 78  90   90   VAL VAL C . n 
E 2 79  CYS 79  91   91   CYS CYS C . n 
E 2 80  ASN 80  92   92   ASN ASN C . n 
E 2 81  ALA 81  93   93   ALA ALA C . n 
E 2 82  LEU 82  94   94   LEU LEU C . n 
E 2 83  ALA 83  95   95   ALA ALA C . n 
E 2 84  LEU 84  96   96   LEU LEU C . n 
E 2 85  LEU 85  97   97   LEU LEU C . n 
E 2 86  GLN 86  98   98   GLN GLN C . n 
E 2 87  CYS 87  99   99   CYS CYS C . n 
E 2 88  VAL 88  100  100  VAL VAL C . n 
E 2 89  ALA 89  101  101  ALA ALA C . n 
E 2 90  SER 90  102  102  SER SER C . n 
E 2 91  HIS 91  103  103  HIS HIS C . n 
E 2 92  PRO 92  104  104  PRO PRO C . n 
E 2 93  GLU 93  105  105  GLU GLU C . n 
E 2 94  THR 94  106  106  THR THR C . n 
E 2 95  ARG 95  107  107  ARG ARG C . n 
E 2 96  SER 96  108  108  SER SER C . n 
E 2 97  ALA 97  109  109  ALA ALA C . n 
E 2 98  PHE 98  110  110  PHE PHE C . n 
E 2 99  LEU 99  111  111  LEU LEU C . n 
E 2 100 ALA 100 112  112  ALA ALA C . n 
E 2 101 ALA 101 113  113  ALA ALA C . n 
E 2 102 HIS 102 114  114  HIS HIS C . n 
E 2 103 ILE 103 115  115  ILE ILE C . n 
E 2 104 PRO 104 116  116  PRO PRO C . n 
E 2 105 LEU 105 117  117  LEU LEU C . n 
E 2 106 PHE 106 118  118  PHE PHE C . n 
E 2 107 LEU 107 119  119  LEU LEU C . n 
E 2 108 TYR 108 120  120  TYR TYR C . n 
E 2 109 PRO 109 121  121  PRO PRO C . n 
E 2 110 PHE 110 122  122  PHE PHE C . n 
E 2 111 LEU 111 123  123  LEU LEU C . n 
E 2 112 HIS 112 124  124  HIS HIS C . n 
E 2 113 THR 113 125  125  THR THR C . n 
E 2 114 VAL 114 126  126  VAL VAL C . n 
E 2 115 SER 115 127  127  SER SER C . n 
E 2 116 LYS 116 128  128  LYS LYS C . n 
E 2 117 THR 117 129  129  THR THR C . n 
E 2 118 ARG 118 130  130  ARG ARG C . n 
E 2 119 PRO 119 131  131  PRO PRO C . n 
E 2 120 PHE 120 132  132  PHE PHE C . n 
E 2 121 GLU 121 133  133  GLU GLU C . n 
E 2 122 TYR 122 134  134  TYR TYR C . n 
E 2 123 LEU 123 135  135  LEU LEU C . n 
E 2 124 ARG 124 136  136  ARG ARG C . n 
E 2 125 LEU 125 137  137  LEU LEU C . n 
E 2 126 THR 126 138  138  THR THR C . n 
E 2 127 SER 127 139  139  SER SER C . n 
E 2 128 LEU 128 140  140  LEU LEU C . n 
E 2 129 GLY 129 141  141  GLY GLY C . n 
E 2 130 VAL 130 142  142  VAL VAL C . n 
E 2 131 ILE 131 143  143  ILE ILE C . n 
E 2 132 GLY 132 144  144  GLY GLY C . n 
E 2 133 ALA 133 145  145  ALA ALA C . n 
E 2 134 LEU 134 146  146  LEU LEU C . n 
E 2 135 VAL 135 147  147  VAL VAL C . n 
E 2 136 LYS 136 148  148  LYS LYS C . n 
E 2 137 THR 137 149  149  THR THR C . n 
E 2 138 ASP 138 150  150  ASP ASP C . n 
E 2 139 GLU 139 151  151  GLU GLU C . n 
E 2 140 GLN 140 152  152  GLN GLN C . n 
E 2 141 GLU 141 153  153  GLU GLU C . n 
E 2 142 VAL 142 154  154  VAL VAL C . n 
E 2 143 ILE 143 155  155  ILE ILE C . n 
E 2 144 ASN 144 156  156  ASN ASN C . n 
E 2 145 PHE 145 157  157  PHE PHE C . n 
E 2 146 LEU 146 158  158  LEU LEU C . n 
E 2 147 LEU 147 159  159  LEU LEU C . n 
E 2 148 THR 148 160  160  THR THR C . n 
E 2 149 THR 149 161  161  THR THR C . n 
E 2 150 GLU 150 162  162  GLU GLU C . n 
E 2 151 ILE 151 163  163  ILE ILE C . n 
E 2 152 ILE 152 164  164  ILE ILE C . n 
E 2 153 PRO 153 165  165  PRO PRO C . n 
E 2 154 LEU 154 166  166  LEU LEU C . n 
E 2 155 CYS 155 167  167  CYS CYS C . n 
E 2 156 LEU 156 168  168  LEU LEU C . n 
E 2 157 ARG 157 169  169  ARG ARG C . n 
E 2 158 ILE 158 170  170  ILE ILE C . n 
E 2 159 MET 159 171  171  MET MET C . n 
E 2 160 GLU 160 172  172  GLU GLU C . n 
E 2 161 SER 161 173  173  SER SER C . n 
E 2 162 GLY 162 174  174  GLY GLY C . n 
E 2 163 SER 163 175  175  SER SER C . n 
E 2 164 GLU 164 176  176  GLU GLU C . n 
E 2 165 LEU 165 177  177  LEU LEU C . n 
E 2 166 SER 166 178  178  SER SER C . n 
E 2 167 LYS 167 179  179  LYS LYS C . n 
E 2 168 THR 168 180  180  THR THR C . n 
E 2 169 VAL 169 181  181  VAL VAL C . n 
E 2 170 ALA 170 182  182  ALA ALA C . n 
E 2 171 THR 171 183  183  THR THR C . n 
E 2 172 PHE 172 184  184  PHE PHE C . n 
E 2 173 ILE 173 185  185  ILE ILE C . n 
E 2 174 LEU 174 186  186  LEU LEU C . n 
E 2 175 GLN 175 187  187  GLN GLN C . n 
E 2 176 LYS 176 188  188  LYS LYS C . n 
E 2 177 ILE 177 189  189  ILE ILE C . n 
E 2 178 LEU 178 190  190  LEU LEU C . n 
E 2 179 LEU 179 191  191  LEU LEU C . n 
E 2 180 ASP 180 192  192  ASP ASP C . n 
E 2 181 ASP 181 193  193  ASP ASP C . n 
E 2 182 THR 182 194  194  THR THR C . n 
E 2 183 GLY 183 195  195  GLY GLY C . n 
E 2 184 LEU 184 196  196  LEU LEU C . n 
E 2 185 ALA 185 197  197  ALA ALA C . n 
E 2 186 TYR 186 198  198  TYR TYR C . n 
E 2 187 ILE 187 199  199  ILE ILE C . n 
E 2 188 CYS 188 200  200  CYS CYS C . n 
E 2 189 GLN 189 201  201  GLN GLN C . n 
E 2 190 THR 190 202  202  THR THR C . n 
E 2 191 TYR 191 203  203  TYR TYR C . n 
E 2 192 GLU 192 204  204  GLU GLU C . n 
E 2 193 ARG 193 205  205  ARG ARG C . n 
E 2 194 PHE 194 206  206  PHE PHE C . n 
E 2 195 SER 195 207  207  SER SER C . n 
E 2 196 HIS 196 208  208  HIS HIS C . n 
E 2 197 VAL 197 209  209  VAL VAL C . n 
E 2 198 ALA 198 210  210  ALA ALA C . n 
E 2 199 MET 199 211  211  MET MET C . n 
E 2 200 ILE 200 212  212  ILE ILE C . n 
E 2 201 LEU 201 213  213  LEU LEU C . n 
E 2 202 GLY 202 214  214  GLY GLY C . n 
E 2 203 LYS 203 215  215  LYS LYS C . n 
E 2 204 MET 204 216  216  MET MET C . n 
E 2 205 VAL 205 217  217  VAL VAL C . n 
E 2 206 LEU 206 218  218  LEU LEU C . n 
E 2 207 GLN 207 219  219  GLN GLN C . n 
E 2 208 LEU 208 220  220  LEU LEU C . n 
E 2 209 SER 209 221  221  SER SER C . n 
E 2 210 LYS 210 222  222  LYS LYS C . n 
E 2 211 GLU 211 223  223  GLU GLU C . n 
E 2 212 PRO 212 224  224  PRO PRO C . n 
E 2 213 SER 213 225  225  SER SER C . n 
E 2 214 ALA 214 226  226  ALA ALA C . n 
E 2 215 ARG 215 227  227  ARG ARG C . n 
E 2 216 LEU 216 228  228  LEU LEU C . n 
E 2 217 LEU 217 229  229  LEU LEU C . n 
E 2 218 LYS 218 230  230  LYS LYS C . n 
E 2 219 HIS 219 231  231  HIS HIS C . n 
E 2 220 VAL 220 232  232  VAL VAL C . n 
E 2 221 VAL 221 233  233  VAL VAL C . n 
E 2 222 ARG 222 234  234  ARG ARG C . n 
E 2 223 CYS 223 235  235  CYS CYS C . n 
E 2 224 TYR 224 236  236  TYR TYR C . n 
E 2 225 LEU 225 237  237  LEU LEU C . n 
E 2 226 ARG 226 238  238  ARG ARG C . n 
E 2 227 LEU 227 239  239  LEU LEU C . n 
E 2 228 SER 228 240  240  SER SER C . n 
E 2 229 ASP 229 241  241  ASP ASP C . n 
E 2 230 ASN 230 242  242  ASN ASN C . n 
E 2 231 PRO 231 243  243  PRO PRO C . n 
E 2 232 ARG 232 244  244  ARG ARG C . n 
E 2 233 ALA 233 245  245  ALA ALA C . n 
E 2 234 ARG 234 246  246  ARG ARG C . n 
E 2 235 GLU 235 247  247  GLU GLU C . n 
E 2 236 ALA 236 248  248  ALA ALA C . n 
E 2 237 LEU 237 249  249  LEU LEU C . n 
E 2 238 ARG 238 250  250  ARG ARG C . n 
E 2 239 GLN 239 251  251  GLN GLN C . n 
E 2 240 CYS 240 252  252  CYS CYS C . n 
E 2 241 LEU 241 253  253  LEU LEU C . n 
E 2 242 PRO 242 254  254  PRO PRO C . n 
E 2 243 ASP 243 255  255  ASP ASP C . n 
E 2 244 GLN 244 256  256  GLN GLN C . n 
E 2 245 LEU 245 257  257  LEU LEU C . n 
E 2 246 LYS 246 258  258  LYS LYS C . n 
E 2 247 ASP 247 259  259  ASP ASP C . n 
E 2 248 THR 248 260  260  THR THR C . n 
E 2 249 THR 249 261  261  THR THR C . n 
E 2 250 PHE 250 262  262  PHE PHE C . n 
E 2 251 ALA 251 263  263  ALA ALA C . n 
E 2 252 GLN 252 264  264  GLN GLN C . n 
E 2 253 VAL 253 265  265  VAL VAL C . n 
E 2 254 LEU 254 266  266  LEU LEU C . n 
E 2 255 LYS 255 267  267  LYS LYS C . n 
E 2 256 ASP 256 268  268  ASP ASP C . n 
E 2 257 ASP 257 269  269  ASP ASP C . n 
E 2 258 THR 258 270  270  THR THR C . n 
E 2 259 THR 259 271  271  THR THR C . n 
E 2 260 THR 260 272  272  THR THR C . n 
E 2 261 LYS 261 273  273  LYS LYS C . n 
E 2 262 ARG 262 274  274  ARG ARG C . n 
E 2 263 TRP 263 275  275  TRP TRP C . n 
E 2 264 LEU 264 276  276  LEU LEU C . n 
E 2 265 ALA 265 277  277  ALA ALA C . n 
E 2 266 GLN 266 278  278  GLN GLN C . n 
E 2 267 LEU 267 279  279  LEU LEU C . n 
E 2 268 VAL 268 280  280  VAL VAL C . n 
E 2 269 LYS 269 281  281  LYS LYS C . n 
E 2 270 ASN 270 282  282  ASN ASN C . n 
E 2 271 LEU 271 283  283  LEU LEU C . n 
E 2 272 GLN 272 284  284  GLN GLN C . n 
E 2 273 GLU 273 285  285  GLU GLU C . n 
F 3 1   GLY 1   1345 ?    ?   ?   D . n 
F 3 2   PRO 2   1346 ?    ?   ?   D . n 
F 3 3   HIS 3   1347 ?    ?   ?   D . n 
F 3 4   MET 4   1348 ?    ?   ?   D . n 
F 3 5   LEU 5   1349 ?    ?   ?   D . n 
F 3 6   GLU 6   1350 ?    ?   ?   D . n 
F 3 7   VAL 7   1351 ?    ?   ?   D . n 
F 3 8   PRO 8   1352 ?    ?   ?   D . n 
F 3 9   PRO 9   1353 1353 PRO PRO D . n 
F 3 10  GLN 10  1354 1354 GLN GLN D . n 
F 3 11  PRO 11  1355 1355 PRO PRO D . n 
F 3 12  GLN 12  1356 1356 GLN GLN D . n 
F 3 13  TYR 13  1357 1357 TYR TYR D . n 
F 3 14  SER 14  1358 1358 SER SER D . n 
F 3 15  TYR 15  1359 1359 TYR TYR D . n 
F 3 16  HIS 16  1360 1360 HIS HIS D . n 
F 3 17  ASP 17  1361 1361 ASP ASP D . n 
F 3 18  ILE 18  1362 1362 ILE ILE D . n 
F 3 19  ASN 19  1363 1363 ASN ASN D . n 
F 3 20  VAL 20  1364 1364 VAL VAL D . n 
F 3 21  TYR 21  1365 1365 TYR TYR D . n 
F 3 22  SER 22  1366 1366 SER SER D . n 
F 3 23  LEU 23  1367 1367 LEU LEU D . n 
F 3 24  ALA 24  1368 1368 ALA ALA D . n 
F 3 25  GLY 25  1369 1369 GLY GLY D . n 
F 3 26  LEU 26  1370 1370 LEU LEU D . n 
F 3 27  ALA 27  1371 1371 ALA ALA D . n 
F 3 28  PRO 28  1372 1372 PRO PRO D . n 
F 3 29  HIS 29  1373 1373 HIS HIS D . n 
F 3 30  ILE 30  1374 1374 ILE ILE D . n 
F 3 31  THR 31  1375 1375 THR THR D . n 
F 3 32  LEU 32  1376 1376 LEU LEU D . n 
F 3 33  ASN 33  1377 1377 ASN ASN D . n 
F 3 34  PRO 34  1378 1378 PRO PRO D . n 
F 3 35  THR 35  1379 1379 THR THR D . n 
F 3 36  ILE 36  1380 1380 ILE ILE D . n 
F 3 37  PRO 37  1381 1381 PRO PRO D . n 
F 3 38  LEU 38  1382 1382 LEU LEU D . n 
F 3 39  PHE 39  1383 1383 PHE PHE D . n 
F 3 40  GLN 40  1384 1384 GLN GLN D . n 
F 3 41  ALA 41  1385 1385 ALA ALA D . n 
F 3 42  HIS 42  1386 1386 HIS HIS D . n 
F 3 43  PRO 43  1387 1387 PRO PRO D . n 
F 3 44  GLN 44  1388 1388 GLN GLN D . n 
F 3 45  LEU 45  1389 1389 LEU LEU D . n 
F 3 46  LYS 46  1390 1390 LYS LYS D . n 
F 3 47  GLN 47  1391 1391 GLN GLN D . n 
F 3 48  CYS 48  1392 1392 CYS CYS D . n 
F 3 49  VAL 49  1393 1393 VAL VAL D . n 
F 3 50  ARG 50  1394 1394 ARG ARG D . n 
F 3 51  GLN 51  1395 1395 GLN GLN D . n 
F 3 52  ALA 52  1396 1396 ALA ALA D . n 
F 3 53  ILE 53  1397 1397 ILE ILE D . n 
F 3 54  GLU 54  1398 1398 GLU GLU D . n 
F 3 55  ARG 55  1399 1399 ARG ARG D . n 
F 3 56  ALA 56  1400 1400 ALA ALA D . n 
F 3 57  VAL 57  1401 1401 VAL VAL D . n 
F 3 58  GLN 58  1402 1402 GLN GLN D . n 
F 3 59  GLU 59  1403 1403 GLU GLU D . n 
F 3 60  LEU 60  1404 1404 LEU LEU D . n 
F 3 61  VAL 61  1405 1405 VAL VAL D . n 
F 3 62  HIS 62  1406 1406 HIS HIS D . n 
F 3 63  PRO 63  1407 1407 PRO PRO D . n 
F 3 64  VAL 64  1408 1408 VAL VAL D . n 
F 3 65  VAL 65  1409 1409 VAL VAL D . n 
F 3 66  ASP 66  1410 1410 ASP ASP D . n 
F 3 67  ARG 67  1411 1411 ARG ARG D . n 
F 3 68  SER 68  1412 1412 SER SER D . n 
F 3 69  ILE 69  1413 1413 ILE ILE D . n 
F 3 70  LYS 70  1414 1414 LYS LYS D . n 
F 3 71  ILE 71  1415 1415 ILE ILE D . n 
F 3 72  ALA 72  1416 1416 ALA ALA D . n 
F 3 73  MET 73  1417 1417 MET MET D . n 
F 3 74  THR 74  1418 1418 THR THR D . n 
F 3 75  THR 75  1419 1419 THR THR D . n 
F 3 76  CYS 76  1420 1420 CYS CYS D . n 
F 3 77  GLU 77  1421 1421 GLU GLU D . n 
F 3 78  GLN 78  1422 1422 GLN GLN D . n 
F 3 79  ILE 79  1423 1423 ILE ILE D . n 
F 3 80  VAL 80  1424 1424 VAL VAL D . n 
F 3 81  ARG 81  1425 1425 ARG ARG D . n 
F 3 82  LYS 82  1426 1426 LYS LYS D . n 
F 3 83  ASP 83  1427 1427 ASP ASP D . n 
F 3 84  PHE 84  1428 1428 PHE PHE D . n 
F 3 85  ALA 85  1429 1429 ALA ALA D . n 
F 3 86  LEU 86  1430 1430 LEU LEU D . n 
F 3 87  ASP 87  1431 1431 ASP ASP D . n 
F 3 88  SER 88  1432 1432 SER SER D . n 
F 3 89  GLU 89  1433 1433 GLU GLU D . n 
F 3 90  GLU 90  1434 1434 GLU GLU D . n 
F 3 91  SER 91  1435 1435 SER SER D . n 
F 3 92  ARG 92  1436 1436 ARG ARG D . n 
F 3 93  MET 93  1437 1437 MET MET D . n 
F 3 94  ARG 94  1438 1438 ARG ARG D . n 
F 3 95  ILE 95  1439 1439 ILE ILE D . n 
F 3 96  ALA 96  1440 1440 ALA ALA D . n 
F 3 97  ALA 97  1441 1441 ALA ALA D . n 
F 3 98  HIS 98  1442 1442 HIS HIS D . n 
F 3 99  HIS 99  1443 1443 HIS HIS D . n 
F 3 100 MET 100 1444 1444 MET MET D . n 
F 3 101 MET 101 1445 1445 MET MET D . n 
F 3 102 ARG 102 1446 1446 ARG ARG D . n 
F 3 103 ASN 103 1447 1447 ASN ASN D . n 
F 3 104 LEU 104 1448 1448 LEU LEU D . n 
F 3 105 THR 105 1449 1449 THR THR D . n 
F 3 106 ALA 106 1450 1450 ALA ALA D . n 
F 3 107 GLY 107 1451 1451 GLY GLY D . n 
F 3 108 MET 108 1452 1452 MET MET D . n 
F 3 109 ALA 109 1453 1453 ALA ALA D . n 
F 3 110 MET 110 1454 1454 MET MET D . n 
F 3 111 ILE 111 1455 1455 ILE ILE D . n 
F 3 112 THR 112 1456 1456 THR THR D . n 
F 3 113 CYS 113 1457 1457 CYS CYS D . n 
F 3 114 ARG 114 1458 1458 ARG ARG D . n 
F 3 115 GLU 115 1459 1459 GLU GLU D . n 
F 3 116 PRO 116 1460 1460 PRO PRO D . n 
F 3 117 LEU 117 1461 1461 LEU LEU D . n 
F 3 118 LEU 118 1462 1462 LEU LEU D . n 
F 3 119 MET 119 1463 1463 MET MET D . n 
F 3 120 SER 120 1464 1464 SER SER D . n 
F 3 121 ILE 121 1465 1465 ILE ILE D . n 
F 3 122 SER 122 1466 1466 SER SER D . n 
F 3 123 THR 123 1467 1467 THR THR D . n 
F 3 124 ASN 124 1468 1468 ASN ASN D . n 
F 3 125 LEU 125 1469 1469 LEU LEU D . n 
F 3 126 LYS 126 1470 1470 LYS LYS D . n 
F 3 127 ASN 127 1471 1471 ASN ASN D . n 
F 3 128 SER 128 1472 1472 SER SER D . n 
F 3 129 PHE 129 1473 1473 PHE PHE D . n 
F 3 130 ALA 130 1474 1474 ALA ALA D . n 
F 3 131 SER 131 1475 ?    ?   ?   D . n 
F 3 132 ALA 132 1476 ?    ?   ?   D . n 
F 3 133 LEU 133 1477 ?    ?   ?   D . n 
F 3 134 ARG 134 1478 1478 ARG ARG D . n 
F 3 135 THR 135 1479 1479 THR THR D . n 
F 3 136 ALA 136 1480 1480 ALA ALA D . n 
F 3 137 SER 137 1481 1481 SER SER D . n 
F 3 138 PRO 138 1482 1482 PRO PRO D . n 
F 3 139 GLN 139 1483 1483 GLN GLN D . n 
F 3 140 GLN 140 1484 1484 GLN GLN D . n 
F 3 141 ARG 141 1485 1485 ARG ARG D . n 
F 3 142 GLU 142 1486 1486 GLU GLU D . n 
F 3 143 MET 143 1487 1487 MET MET D . n 
F 3 144 MET 144 1488 1488 MET MET D . n 
F 3 145 ASP 145 1489 1489 ASP ASP D . n 
F 3 146 GLN 146 1490 1490 GLN GLN D . n 
F 3 147 ALA 147 1491 1491 ALA ALA D . n 
F 3 148 ALA 148 1492 1492 ALA ALA D . n 
F 3 149 ALA 149 1493 1493 ALA ALA D . n 
F 3 150 GLN 150 1494 1494 GLN GLN D . n 
F 3 151 LEU 151 1495 1495 LEU LEU D . n 
F 3 152 ALA 152 1496 1496 ALA ALA D . n 
F 3 153 GLN 153 1497 1497 GLN GLN D . n 
F 3 154 ASP 154 1498 1498 ASP ASP D . n 
F 3 155 ASN 155 1499 1499 ASN ASN D . n 
F 3 156 CYS 156 1500 1500 CYS CYS D . n 
F 3 157 GLU 157 1501 1501 GLU GLU D . n 
F 3 158 LEU 158 1502 1502 LEU LEU D . n 
F 3 159 ALA 159 1503 1503 ALA ALA D . n 
F 3 160 CYS 160 1504 1504 CYS CYS D . n 
F 3 161 CYS 161 1505 1505 CYS CYS D . n 
F 3 162 PHE 162 1506 1506 PHE PHE D . n 
F 3 163 ILE 163 1507 1507 ILE ILE D . n 
F 3 164 GLN 164 1508 1508 GLN GLN D . n 
F 3 165 LYS 165 1509 1509 LYS LYS D . n 
F 3 166 THR 166 1510 1510 THR THR D . n 
F 3 167 ALA 167 1511 1511 ALA ALA D . n 
F 3 168 VAL 168 1512 1512 VAL VAL D . n 
F 3 169 GLU 169 1513 1513 GLU GLU D . n 
F 3 170 LYS 170 1514 1514 LYS LYS D . n 
F 3 171 ALA 171 1515 1515 ALA ALA D . n 
F 3 172 GLY 172 1516 1516 GLY GLY D . n 
F 3 173 PRO 173 1517 1517 PRO PRO D . n 
F 3 174 GLU 174 1518 1518 GLU GLU D . n 
F 3 175 MET 175 1519 1519 MET MET D . n 
F 3 176 ASP 176 1520 1520 ASP ASP D . n 
F 3 177 LYS 177 1521 1521 LYS LYS D . n 
F 3 178 ARG 178 1522 1522 ARG ARG D . n 
F 3 179 LEU 179 1523 1523 LEU LEU D . n 
F 3 180 ALA 180 1524 1524 ALA ALA D . n 
F 3 181 THR 181 1525 1525 THR THR D . n 
F 3 182 GLU 182 1526 1526 GLU GLU D . n 
F 3 183 PHE 183 1527 1527 PHE PHE D . n 
F 3 184 GLU 184 1528 1528 GLU GLU D . n 
F 3 185 LEU 185 1529 1529 LEU LEU D . n 
F 3 186 ARG 186 1530 1530 ARG ARG D . n 
F 3 187 LYS 187 1531 1531 LYS LYS D . n 
F 3 188 HIS 188 1532 1532 HIS HIS D . n 
F 3 189 ALA 189 1533 1533 ALA ALA D . n 
F 3 190 ARG 190 1534 1534 ARG ARG D . n 
F 3 191 GLN 191 1535 1535 GLN GLN D . n 
F 3 192 GLU 192 1536 1536 GLU GLU D . n 
F 3 193 GLY 193 1537 1537 GLY GLY D . n 
F 3 194 ARG 194 1538 1538 ARG ARG D . n 
F 3 195 ARG 195 1539 1539 ARG ARG D . n 
F 3 196 TYR 196 1540 1540 TYR TYR D . n 
F 3 197 CYS 197 1541 1541 CYS CYS D . n 
F 3 198 ASP 198 1542 1542 ASP ASP D . n 
F 3 199 PRO 199 1543 1543 PRO PRO D . n 
F 3 200 VAL 200 1544 1544 VAL VAL D . n 
F 3 201 VAL 201 1545 1545 VAL VAL D . n 
F 3 202 LEU 202 1546 1546 LEU LEU D . n 
F 3 203 THR 203 1547 1547 THR THR D . n 
F 3 204 TYR 204 1548 1548 TYR TYR D . n 
F 3 205 GLN 205 1549 1549 GLN GLN D . n 
F 3 206 ALA 206 1550 1550 ALA ALA D . n 
F 3 207 GLU 207 1551 1551 GLU GLU D . n 
F 3 208 ARG 208 1552 1552 ARG ARG D . n 
F 3 209 MET 209 1553 1553 MET MET D . n 
F 3 210 PRO 210 1554 1554 PRO PRO D . n 
F 3 211 GLU 211 1555 1555 GLU GLU D . n 
F 3 212 GLN 212 1556 1556 GLN GLN D . n 
F 3 213 ILE 213 1557 1557 ILE ILE D . n 
F 3 214 ARG 214 1558 1558 ARG ARG D . n 
F 3 215 LEU 215 1559 1559 LEU LEU D . n 
F 3 216 LYS 216 1560 1560 LYS LYS D . n 
F 3 217 VAL 217 1561 1561 VAL VAL D . n 
F 3 218 GLY 218 1562 1562 GLY GLY D . n 
F 3 219 GLY 219 1563 1563 GLY GLY D . n 
F 3 220 VAL 220 1564 1564 VAL VAL D . n 
F 3 221 ASP 221 1565 1565 ASP ASP D . n 
F 3 222 PRO 222 1566 1566 PRO PRO D . n 
F 3 223 LYS 223 1567 1567 LYS LYS D . n 
F 3 224 GLN 224 1568 1568 GLN GLN D . n 
F 3 225 LEU 225 1569 1569 LEU LEU D . n 
F 3 226 ALA 226 1570 1570 ALA ALA D . n 
F 3 227 VAL 227 1571 1571 VAL VAL D . n 
F 3 228 TYR 228 1572 1572 TYR TYR D . n 
F 3 229 GLU 229 1573 1573 GLU GLU D . n 
F 3 230 GLU 230 1574 1574 GLU GLU D . n 
F 3 231 PHE 231 1575 1575 PHE PHE D . n 
F 3 232 ALA 232 1576 1576 ALA ALA D . n 
F 3 233 ARG 233 1577 1577 ARG ARG D . n 
F 3 234 ASN 234 1578 1578 ASN ASN D . n 
F 3 235 VAL 235 1579 1579 VAL VAL D . n 
F 3 236 PRO 236 1580 1580 PRO PRO D . n 
F 3 237 GLY 237 1581 1581 GLY GLY D . n 
F 3 238 PHE 238 1582 1582 PHE PHE D . n 
F 3 239 LEU 239 1583 1583 LEU LEU D . n 
F 3 240 PRO 240 1584 1584 PRO PRO D . n 
F 3 241 THR 241 1585 1585 THR THR D . n 
F 3 242 ASN 242 1586 1586 ASN ASN D . n 
F 3 243 ASP 243 1587 1587 ASP ASP D . n 
F 3 244 LEU 244 1588 1588 LEU LEU D . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 MK8 ? ? MK8 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 NLE ? ? NLE ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 4 BU1 1  101  1605 BU1 BU1 F . 
H 4 BU1 1  301  301  BU1 BU1 B . 
I 4 BU1 1  302  302  BU1 BU1 B . 
J 4 BU1 1  1601 1601 BU1 BU1 A . 
K 4 BU1 1  1602 1603 BU1 BU1 A . 
L 4 BU1 1  301  1604 BU1 BU1 C . 
M 5 HOH 1  101  10   HOH HOH G . 
M 5 HOH 2  102  6    HOH HOH G . 
M 5 HOH 3  103  42   HOH HOH G . 
N 5 HOH 1  401  3    HOH HOH B . 
N 5 HOH 2  402  4    HOH HOH B . 
N 5 HOH 3  403  5    HOH HOH B . 
N 5 HOH 4  404  36   HOH HOH B . 
O 5 HOH 1  1701 12   HOH HOH A . 
O 5 HOH 2  1702 13   HOH HOH A . 
O 5 HOH 3  1703 31   HOH HOH A . 
O 5 HOH 4  1704 35   HOH HOH A . 
O 5 HOH 5  1705 2    HOH HOH A . 
O 5 HOH 6  1706 32   HOH HOH A . 
O 5 HOH 7  1707 38   HOH HOH A . 
O 5 HOH 8  1708 11   HOH HOH A . 
O 5 HOH 9  1709 33   HOH HOH A . 
O 5 HOH 10 1710 25   HOH HOH A . 
O 5 HOH 11 1711 26   HOH HOH A . 
O 5 HOH 12 1712 24   HOH HOH A . 
O 5 HOH 13 1713 30   HOH HOH A . 
O 5 HOH 14 1714 27   HOH HOH A . 
O 5 HOH 15 1715 46   HOH HOH A . 
O 5 HOH 16 1716 34   HOH HOH A . 
O 5 HOH 17 1717 8    HOH HOH A . 
O 5 HOH 18 1718 9    HOH HOH A . 
O 5 HOH 19 1719 29   HOH HOH A . 
O 5 HOH 20 1720 28   HOH HOH A . 
O 5 HOH 21 1721 37   HOH HOH A . 
O 5 HOH 22 1722 14   HOH HOH A . 
O 5 HOH 23 1723 43   HOH HOH A . 
O 5 HOH 24 1724 45   HOH HOH A . 
P 5 HOH 1  401  23   HOH HOH C . 
P 5 HOH 2  402  22   HOH HOH C . 
P 5 HOH 3  403  1    HOH HOH C . 
P 5 HOH 4  404  7    HOH HOH C . 
P 5 HOH 5  405  21   HOH HOH C . 
P 5 HOH 6  406  16   HOH HOH C . 
P 5 HOH 7  407  15   HOH HOH C . 
P 5 HOH 8  408  40   HOH HOH C . 
P 5 HOH 9  409  20   HOH HOH C . 
P 5 HOH 10 410  17   HOH HOH C . 
P 5 HOH 11 411  39   HOH HOH C . 
P 5 HOH 12 412  41   HOH HOH C . 
P 5 HOH 13 413  18   HOH HOH C . 
P 5 HOH 14 414  19   HOH HOH C . 
Q 5 HOH 1  1601 44   HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .               2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .               3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .               4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FL8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     106.562 
_cell.length_a_esd                 ? 
_cell.length_b                     106.562 
_cell.length_b_esd                 ? 
_cell.length_c                     262.572 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FL8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FL8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.86 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          33.85 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2M sodium formate, 0.1M sodium acetate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-09-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.88560 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.88560 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9FL8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.64 
_reflns.d_resolution_low                               131.286 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26138 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           50.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.208 
_reflns.pdbx_Rpim_I_all                                0.047 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.202 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.645 
_reflns_shell.d_res_low                                     2.970 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           25814 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1307 
_reflns_shell.percent_possible_obs                          8.8 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               19.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.8 
_reflns_shell.pdbx_Rrim_I_all                               2.020 
_reflns_shell.pdbx_Rpim_I_all                               0.450 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.968 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FL8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.64 
_refine.ls_d_res_low                             46.14 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26063 
_refine.ls_number_reflns_R_free                  1304 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    50.67 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2052 
_refine.ls_R_factor_R_free                       0.2495 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2028 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.65 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.22 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.64 
_refine_hist.d_res_low                        46.14 
_refine_hist.number_atoms_solvent             46 
_refine_hist.number_atoms_total               8441 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        8359 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         36 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.004 ? 8610  ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.653 ? 11661 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 8.833 ? 1205  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.038 ? 1344  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.006 ? 1503  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.64 2.75  . . 14  194  4.00   . . . . 0.4682 . . . . . . . . . . . 0.6277 
'X-RAY DIFFRACTION' 2.75 2.88  . . 34  506  10.00  . . . . 0.4127 . . . . . . . . . . . 0.4977 
'X-RAY DIFFRACTION' 2.88 3.03  . . 28  906  17.00  . . . . 0.3508 . . . . . . . . . . . 0.4758 
'X-RAY DIFFRACTION' 3.03 3.22  . . 57  1345 25.00  . . . . 0.3169 . . . . . . . . . . . 0.3275 
'X-RAY DIFFRACTION' 3.22 3.47  . . 78  1996 37.00  . . . . 0.2782 . . . . . . . . . . . 0.3704 
'X-RAY DIFFRACTION' 3.47 3.81  . . 201 3353 62.00  . . . . 0.2341 . . . . . . . . . . . 0.3054 
'X-RAY DIFFRACTION' 3.81 4.36  . . 293 5250 97.00  . . . . 0.1976 . . . . . . . . . . . 0.2630 
'X-RAY DIFFRACTION' 4.37 5.50  . . 285 5492 100.00 . . . . 0.1848 . . . . . . . . . . . 0.2463 
'X-RAY DIFFRACTION' 5.50 46.14 . . 314 5717 100.00 . . . . 0.1791 . . . . . . . . . . . 0.1978 
# 
_struct.entry_id                     9FL8 
_struct.title                        'Stapled peptide bound to NOT9-NOT1 complex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FL8 
_struct_keywords.text            'protein-peptide interaction, inhibitor, CCR4-NOT, RNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'RNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 5 ? 
N N N 5 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP BAM_DROME   P22745 ? 1 LDHNFKQMEEHLALMVE 17   
2 UNP CNOT9_HUMAN Q92600 ? 2 
;REKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQ
CVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELS
KTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLK
DTTFAQVLKDDTTTKRWLAQLVKNLQE
;
19   
3 UNP CNOT1_HUMAN A5YKK6 ? 3 
;VPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFAL
DSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKT
AVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDL
;
1351 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9FL8 G 2 ? 18  ? P22745 17   ? 33   ? 17   33   
2 1 9FL8 F 2 ? 18  ? P22745 17   ? 33   ? 17   33   
3 2 9FL8 B 7 ? 273 ? Q92600 19   ? 285  ? 19   285  
4 3 9FL8 A 7 ? 244 ? A5YKK6 1351 ? 1588 ? 1351 1588 
5 2 9FL8 C 7 ? 273 ? Q92600 19   ? 285  ? 19   285  
6 3 9FL8 D 7 ? 244 ? A5YKK6 1351 ? 1588 ? 1351 1588 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FL8 ACE G 1  ? UNP P22745 ?   ?  acetylation           16   1  
1 9FL8 MK8 G 4  ? UNP P22745 HIS 19 'engineered mutation' 19   2  
1 9FL8 MK8 G 8  ? UNP P22745 GLN 23 'engineered mutation' 23   3  
1 9FL8 NLE G 9  ? UNP P22745 MET 24 'engineered mutation' 24   4  
1 9FL8 NLE G 16 ? UNP P22745 MET 31 'engineered mutation' 31   5  
1 9FL8 NH2 G 19 ? UNP P22745 ?   ?  amidation             34   6  
2 9FL8 ACE F 1  ? UNP P22745 ?   ?  acetylation           16   7  
2 9FL8 MK8 F 4  ? UNP P22745 HIS 19 'engineered mutation' 19   8  
2 9FL8 MK8 F 8  ? UNP P22745 GLN 23 'engineered mutation' 23   9  
2 9FL8 NLE F 9  ? UNP P22745 MET 24 'engineered mutation' 24   10 
2 9FL8 NLE F 16 ? UNP P22745 MET 31 'engineered mutation' 31   11 
2 9FL8 NH2 F 19 ? UNP P22745 ?   ?  amidation             34   12 
3 9FL8 GLY B 1  ? UNP Q92600 ?   ?  'expression tag'      13   13 
3 9FL8 PRO B 2  ? UNP Q92600 ?   ?  'expression tag'      14   14 
3 9FL8 HIS B 3  ? UNP Q92600 ?   ?  'expression tag'      15   15 
3 9FL8 MET B 4  ? UNP Q92600 ?   ?  'expression tag'      16   16 
3 9FL8 LEU B 5  ? UNP Q92600 ?   ?  'expression tag'      17   17 
3 9FL8 GLU B 6  ? UNP Q92600 ?   ?  'expression tag'      18   18 
4 9FL8 GLY A 1  ? UNP A5YKK6 ?   ?  'expression tag'      1345 19 
4 9FL8 PRO A 2  ? UNP A5YKK6 ?   ?  'expression tag'      1346 20 
4 9FL8 HIS A 3  ? UNP A5YKK6 ?   ?  'expression tag'      1347 21 
4 9FL8 MET A 4  ? UNP A5YKK6 ?   ?  'expression tag'      1348 22 
4 9FL8 LEU A 5  ? UNP A5YKK6 ?   ?  'expression tag'      1349 23 
4 9FL8 GLU A 6  ? UNP A5YKK6 ?   ?  'expression tag'      1350 24 
5 9FL8 GLY C 1  ? UNP Q92600 ?   ?  'expression tag'      13   25 
5 9FL8 PRO C 2  ? UNP Q92600 ?   ?  'expression tag'      14   26 
5 9FL8 HIS C 3  ? UNP Q92600 ?   ?  'expression tag'      15   27 
5 9FL8 MET C 4  ? UNP Q92600 ?   ?  'expression tag'      16   28 
5 9FL8 LEU C 5  ? UNP Q92600 ?   ?  'expression tag'      17   29 
5 9FL8 GLU C 6  ? UNP Q92600 ?   ?  'expression tag'      18   30 
6 9FL8 GLY D 1  ? UNP A5YKK6 ?   ?  'expression tag'      1345 31 
6 9FL8 PRO D 2  ? UNP A5YKK6 ?   ?  'expression tag'      1346 32 
6 9FL8 HIS D 3  ? UNP A5YKK6 ?   ?  'expression tag'      1347 33 
6 9FL8 MET D 4  ? UNP A5YKK6 ?   ?  'expression tag'      1348 34 
6 9FL8 LEU D 5  ? UNP A5YKK6 ?   ?  'expression tag'      1349 35 
6 9FL8 GLU D 6  ? UNP A5YKK6 ?   ?  'expression tag'      1350 36 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   hexameric 
_pdbx_struct_assembly.oligomeric_count     6 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 14260 ? 
1 MORE         -66   ? 
1 'SSA (A^2)'  44660 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 2   ? VAL A 17  ? LEU G 17   VAL G 32   1 ? 16 
HELX_P HELX_P2  AA2 LEU B 2   ? GLU B 18  ? LEU F 17   GLU F 33   1 ? 17 
HELX_P HELX_P3  AA3 PRO C 2   ? LEU C 17  ? PRO B 14   LEU B 29   1 ? 16 
HELX_P HELX_P4  AA4 THR C 22  ? LYS C 33  ? THR B 34   LYS B 45   1 ? 12 
HELX_P HELX_P5  AA5 ASP C 39  ? SER C 47  ? ASP B 51   SER B 59   1 ? 9  
HELX_P HELX_P6  AA6 GLY C 49  ? ASN C 60  ? GLY B 61   ASN B 72   1 ? 12 
HELX_P HELX_P7  AA7 ILE C 61  ? ILE C 65  ? ILE B 73   ILE B 77   5 ? 5  
HELX_P HELX_P8  AA8 THR C 71  ? HIS C 91  ? THR B 83   HIS B 103  1 ? 21 
HELX_P HELX_P9  AA9 HIS C 91  ? ALA C 101 ? HIS B 103  ALA B 113  1 ? 11 
HELX_P HELX_P10 AB1 HIS C 102 ? PHE C 106 ? HIS B 114  PHE B 118  5 ? 5  
HELX_P HELX_P11 AB2 LEU C 107 ? HIS C 112 ? LEU B 119  HIS B 124  1 ? 6  
HELX_P HELX_P12 AB3 THR C 117 ? THR C 137 ? THR B 129  THR B 149  1 ? 21 
HELX_P HELX_P13 AB4 GLU C 139 ? GLU C 150 ? GLU B 151  GLU B 162  1 ? 12 
HELX_P HELX_P14 AB5 ILE C 151 ? SER C 161 ? ILE B 163  SER B 173  1 ? 11 
HELX_P HELX_P15 AB6 SER C 163 ? ASP C 180 ? SER B 175  ASP B 192  1 ? 18 
HELX_P HELX_P16 AB7 ASP C 180 ? CYS C 188 ? ASP B 192  CYS B 200  1 ? 9  
HELX_P HELX_P17 AB8 THR C 190 ? GLU C 211 ? THR B 202  GLU B 223  1 ? 22 
HELX_P HELX_P18 AB9 SER C 213 ? ASP C 229 ? SER B 225  ASP B 241  1 ? 17 
HELX_P HELX_P19 AC1 ASN C 230 ? LEU C 241 ? ASN B 242  LEU B 253  1 ? 12 
HELX_P HELX_P20 AC2 PRO C 242 ? ASP C 247 ? PRO B 254  ASP B 259  1 ? 6  
HELX_P HELX_P21 AC3 GLN C 252 ? ASP C 256 ? GLN B 264  ASP B 268  5 ? 5  
HELX_P HELX_P22 AC4 ASP C 257 ? LEU C 271 ? ASP B 269  LEU B 283  1 ? 15 
HELX_P HELX_P23 AC5 SER D 22  ? ILE D 30  ? SER A 1366 ILE A 1374 5 ? 9  
HELX_P HELX_P24 AC6 ILE D 36  ? HIS D 42  ? ILE A 1380 HIS A 1386 1 ? 7  
HELX_P HELX_P25 AC7 PRO D 43  ? LYS D 46  ? PRO A 1387 LYS A 1390 5 ? 4  
HELX_P HELX_P26 AC8 GLN D 47  ? PHE D 84  ? GLN A 1391 PHE A 1428 1 ? 38 
HELX_P HELX_P27 AC9 GLU D 89  ? ARG D 134 ? GLU A 1433 ARG A 1478 1 ? 46 
HELX_P HELX_P28 AD1 SER D 137 ? LEU D 179 ? SER A 1481 LEU A 1523 1 ? 43 
HELX_P HELX_P29 AD2 LEU D 179 ? GLU D 192 ? LEU A 1523 GLU A 1536 1 ? 14 
HELX_P HELX_P30 AD3 ASP D 198 ? MET D 209 ? ASP A 1542 MET A 1553 1 ? 12 
HELX_P HELX_P31 AD4 PRO D 210 ? ARG D 214 ? PRO A 1554 ARG A 1558 5 ? 5  
HELX_P HELX_P32 AD5 LEU D 225 ? ASN D 234 ? LEU A 1569 ASN A 1578 1 ? 10 
HELX_P HELX_P33 AD6 PRO E 2   ? LEU E 17  ? PRO C 14   LEU C 29   1 ? 16 
HELX_P HELX_P34 AD7 THR E 22  ? LYS E 33  ? THR C 34   LYS C 45   1 ? 12 
HELX_P HELX_P35 AD8 ASP E 39  ? HIS E 46  ? ASP C 51   HIS C 58   1 ? 8  
HELX_P HELX_P36 AD9 GLY E 49  ? ASN E 60  ? GLY C 61   ASN C 72   1 ? 12 
HELX_P HELX_P37 AE1 ILE E 61  ? ASN E 66  ? ILE C 73   ASN C 78   1 ? 6  
HELX_P HELX_P38 AE2 THR E 71  ? HIS E 91  ? THR C 83   HIS C 103  1 ? 21 
HELX_P HELX_P39 AE3 THR E 94  ? ALA E 101 ? THR C 106  ALA C 113  1 ? 8  
HELX_P HELX_P40 AE4 ILE E 103 ? PHE E 106 ? ILE C 115  PHE C 118  5 ? 4  
HELX_P HELX_P41 AE5 LEU E 107 ? HIS E 112 ? LEU C 119  HIS C 124  1 ? 6  
HELX_P HELX_P42 AE6 THR E 117 ? THR E 137 ? THR C 129  THR C 149  1 ? 21 
HELX_P HELX_P43 AE7 GLU E 139 ? THR E 149 ? GLU C 151  THR C 161  1 ? 11 
HELX_P HELX_P44 AE8 GLU E 150 ? SER E 161 ? GLU C 162  SER C 173  1 ? 12 
HELX_P HELX_P45 AE9 SER E 163 ? ASP E 180 ? SER C 175  ASP C 192  1 ? 18 
HELX_P HELX_P46 AF1 ASP E 180 ? GLN E 189 ? ASP C 192  GLN C 201  1 ? 10 
HELX_P HELX_P47 AF2 THR E 190 ? GLU E 211 ? THR C 202  GLU C 223  1 ? 22 
HELX_P HELX_P48 AF3 SER E 213 ? SER E 228 ? SER C 225  SER C 240  1 ? 16 
HELX_P HELX_P49 AF4 ASN E 230 ? LEU E 241 ? ASN C 242  LEU C 253  1 ? 12 
HELX_P HELX_P50 AF5 PHE E 250 ? LYS E 255 ? PHE C 262  LYS C 267  1 ? 6  
HELX_P HELX_P51 AF6 ASP E 257 ? LEU E 271 ? ASP C 269  LEU C 283  1 ? 15 
HELX_P HELX_P52 AF7 SER F 14  ? ILE F 18  ? SER D 1358 ILE D 1362 5 ? 5  
HELX_P HELX_P53 AF8 SER F 22  ? ILE F 30  ? SER D 1366 ILE D 1374 5 ? 9  
HELX_P HELX_P54 AF9 LEU F 45  ? GLN F 47  ? LEU D 1389 GLN D 1391 5 ? 3  
HELX_P HELX_P55 AG1 CYS F 48  ? PHE F 84  ? CYS D 1392 PHE D 1428 1 ? 37 
HELX_P HELX_P56 AG2 GLU F 89  ? LYS F 126 ? GLU D 1433 LYS D 1470 1 ? 38 
HELX_P HELX_P57 AG3 SER F 137 ? LEU F 179 ? SER D 1481 LEU D 1523 1 ? 43 
HELX_P HELX_P58 AG4 LEU F 179 ? GLU F 192 ? LEU D 1523 GLU D 1536 1 ? 14 
HELX_P HELX_P59 AG5 ASP F 198 ? MET F 209 ? ASP D 1542 MET D 1553 1 ? 12 
HELX_P HELX_P60 AG6 PRO F 210 ? ARG F 214 ? PRO D 1554 ARG D 1558 5 ? 5  
HELX_P HELX_P61 AG7 LEU F 225 ? ASN F 234 ? LEU D 1569 ASN D 1578 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? D CYS 113 SG A ? ? 1_555 D CYS 160 SG A ? A CYS 1457 A CYS 1504 1_555 ? ? ? ? ? ? ? 2.143 ? ? 
disulf2  disulf ?    ? F CYS 113 SG ? ? ? 1_555 F CYS 160 SG ? ? D CYS 1457 D CYS 1504 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
covale1  covale both ? A ASP 3   C  ? ? ? 1_555 A MK8 4   N  ? ? G ASP 18   G MK8 19   1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale2  covale both ? A MK8 4   C  ? ? ? 1_555 A ASN 5   N  ? ? G MK8 19   G ASN 20   1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale3  covale none ? A MK8 4   CE ? ? ? 1_555 A MK8 8   CE ? ? G MK8 19   G MK8 23   1_555 ? ? ? ? ? ? ? 1.460 ? ? 
covale4  covale both ? A LYS 7   C  ? ? ? 1_555 A MK8 8   N  ? ? G LYS 22   G MK8 23   1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale5  covale both ? A MK8 8   C  ? ? ? 1_555 A NLE 9   N  ? ? G MK8 23   G NLE 24   1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale6  covale both ? A NLE 9   C  ? ? ? 1_555 A GLU 10  N  ? ? G NLE 24   G GLU 25   1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale7  covale both ? A LEU 15  C  ? ? ? 1_555 A NLE 16  N  ? ? G LEU 30   G NLE 31   1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale8  covale both ? A NLE 16  C  ? ? ? 1_555 A VAL 17  N  ? ? G NLE 31   G VAL 32   1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale9  covale both ? B ACE 1   C  ? ? ? 1_555 B LEU 2   N  ? ? F ACE 16   F LEU 17   1_555 ? ? ? ? ? ? ? 1.322 ? ? 
covale10 covale both ? B ASP 3   C  ? ? ? 1_555 B MK8 4   N  ? ? F ASP 18   F MK8 19   1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale11 covale both ? B MK8 4   C  ? ? ? 1_555 B ASN 5   N  ? ? F MK8 19   F ASN 20   1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale12 covale none ? B MK8 4   CE ? ? ? 1_555 B MK8 8   CE ? ? F MK8 19   F MK8 23   1_555 ? ? ? ? ? ? ? 1.612 ? ? 
covale13 covale both ? B LYS 7   C  ? ? ? 1_555 B MK8 8   N  ? ? F LYS 22   F MK8 23   1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale14 covale both ? B MK8 8   C  ? ? ? 1_555 B NLE 9   N  ? ? F MK8 23   F NLE 24   1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale15 covale both ? B NLE 9   C  ? ? ? 1_555 B GLU 10  N  ? ? F NLE 24   F GLU 25   1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale16 covale both ? B LEU 15  C  ? ? ? 1_555 B NLE 16  N  ? ? F LEU 30   F NLE 31   1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale17 covale both ? B NLE 16  C  ? ? ? 1_555 B VAL 17  N  ? ? F NLE 31   F VAL 32   1_555 ? ? ? ? ? ? ? 1.327 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  MK8 A 4   ? .   . .   . MK8 G 19   ? 1_555 .   . .    . .     .  .  LEU 1  MK8 Norleucine  'Named protein modification' 
2  MK8 A 4   ? .   . .   . MK8 G 19   ? 1_555 .   . .    . .     .  .  LEU 2  MK8 Methylation 'Named protein modification' 
3  MK8 A 8   ? .   . .   . MK8 G 23   ? 1_555 .   . .    . .     .  .  LEU 1  MK8 Norleucine  'Named protein modification' 
4  MK8 A 8   ? .   . .   . MK8 G 23   ? 1_555 .   . .    . .     .  .  LEU 2  MK8 Methylation 'Named protein modification' 
5  NLE A 9   ? .   . .   . NLE G 24   ? 1_555 .   . .    . .     .  .  LEU 1  NLE Norleucine  'Named protein modification' 
6  NLE A 16  ? .   . .   . NLE G 31   ? 1_555 .   . .    . .     .  .  LEU 1  NLE Norleucine  'Named protein modification' 
7  MK8 B 4   ? .   . .   . MK8 F 19   ? 1_555 .   . .    . .     .  .  LEU 1  MK8 Norleucine  'Named protein modification' 
8  MK8 B 4   ? .   . .   . MK8 F 19   ? 1_555 .   . .    . .     .  .  LEU 2  MK8 Methylation 'Named protein modification' 
9  MK8 B 8   ? .   . .   . MK8 F 23   ? 1_555 .   . .    . .     .  .  LEU 1  MK8 Norleucine  'Named protein modification' 
10 MK8 B 8   ? .   . .   . MK8 F 23   ? 1_555 .   . .    . .     .  .  LEU 2  MK8 Methylation 'Named protein modification' 
11 NLE B 9   ? .   . .   . NLE F 24   ? 1_555 .   . .    . .     .  .  LEU 1  NLE Norleucine  'Named protein modification' 
12 NLE B 16  ? .   . .   . NLE F 31   ? 1_555 .   . .    . .     .  .  LEU 1  NLE Norleucine  'Named protein modification' 
13 ACE B 1   ? LEU B 2   ? ACE F 16   ? 1_555 LEU F 17   ? 1_555 .  .  LEU 14 ACE None        'Terminal acetylation'       
14 CYS D 113 A CYS D 160 A CYS A 1457 ? 1_555 CYS A 1504 ? 1_555 SG SG .   .  .   None        'Disulfide bridge'           
15 CYS F 113 ? CYS F 160 ? CYS D 1457 ? 1_555 CYS D 1504 ? 1_555 SG SG .   .  .   None        'Disulfide bridge'           
16 MK8 A 4   ? MK8 A 8   ? MK8 G 19   ? 1_555 MK8 G 23   ? 1_555 CE CE .   .  .   None        'Non-standard linkage'       
17 MK8 B 4   ? MK8 B 8   ? MK8 F 19   ? 1_555 MK8 F 23   ? 1_555 CE CE .   .  .   None        'Non-standard linkage'       
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          ASN 
_struct_mon_prot_cis.label_seq_id           66 
_struct_mon_prot_cis.label_asym_id          C 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           ASN 
_struct_mon_prot_cis.auth_seq_id            78 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    67 
_struct_mon_prot_cis.pdbx_label_asym_id_2   C 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     79 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -2.49 
# 
_pdbx_entry_details.entry_id                   9FL8 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 NH1 A ARG 1485 ? ? O   A HOH 1701 ? ? 2.04 
2 1 O   D MET 1463 ? ? OG1 D THR 1467 ? ? 2.12 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    D 
_pdbx_validate_symm_contact.auth_comp_id_1    GLN 
_pdbx_validate_symm_contact.auth_seq_id_1     1391 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    NE2 
_pdbx_validate_symm_contact.auth_asym_id_2    D 
_pdbx_validate_symm_contact.auth_comp_id_2    GLN 
_pdbx_validate_symm_contact.auth_seq_id_2     1391 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_554 
_pdbx_validate_symm_contact.dist              2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 VAL B 126  ? ? -147.59 14.94   
2  1 SER B 173  ? ? -93.88  -158.72 
3  1 ASP B 259  ? ? -96.22  -154.25 
4  1 ARG A 1478 ? ? 62.83   -52.42  
5  1 LYS A 1567 ? ? 94.71   -19.45  
6  1 PRO C 80   ? ? -61.54  85.36   
7  1 LYS C 258  ? ? 87.69   1.98    
8  1 THR C 260  ? ? 46.40   25.87   
9  1 LEU C 283  ? ? -88.35  33.49   
10 1 GLN D 1356 ? ? -155.26 -30.95  
11 1 ASN D 1377 ? ? 48.96   77.38   
12 1 LEU D 1382 ? ? -122.39 -52.99  
13 1 LYS D 1470 ? ? 57.91   -62.40  
14 1 ASN D 1471 ? ? 71.92   -49.08  
15 1 THR D 1585 ? ? -109.67 -82.60  
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1724 ? 6.09  . 
2 1 O ? C HOH 412  ? 6.45  . 
3 1 O ? C HOH 413  ? 7.10  . 
4 1 O ? C HOH 414  ? 10.15 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 G ACE 16   ? A ACE 1   
2  1 Y 1 G NH2 34   ? A NH2 19  
3  1 Y 1 F NH2 34   ? B NH2 19  
4  1 Y 1 A GLY 1345 ? D GLY 1   
5  1 Y 1 A PRO 1346 ? D PRO 2   
6  1 Y 1 A HIS 1347 ? D HIS 3   
7  1 Y 1 A MET 1348 ? D MET 4   
8  1 Y 1 A LEU 1349 ? D LEU 5   
9  1 Y 1 A GLU 1350 ? D GLU 6   
10 1 Y 1 A VAL 1351 ? D VAL 7   
11 1 Y 1 A PRO 1352 ? D PRO 8   
12 1 Y 1 A PRO 1353 ? D PRO 9   
13 1 Y 1 D GLY 1345 ? F GLY 1   
14 1 Y 1 D PRO 1346 ? F PRO 2   
15 1 Y 1 D HIS 1347 ? F HIS 3   
16 1 Y 1 D MET 1348 ? F MET 4   
17 1 Y 1 D LEU 1349 ? F LEU 5   
18 1 Y 1 D GLU 1350 ? F GLU 6   
19 1 Y 1 D VAL 1351 ? F VAL 7   
20 1 Y 1 D PRO 1352 ? F PRO 8   
21 1 Y 1 D SER 1475 ? F SER 131 
22 1 Y 1 D ALA 1476 ? F ALA 132 
23 1 Y 1 D LEU 1477 ? F LEU 133 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACE C    C N N 1   
ACE O    O N N 2   
ACE CH3  C N N 3   
ACE H    H N N 4   
ACE H1   H N N 5   
ACE H2   H N N 6   
ACE H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
BU1 C1   C N N 81  
BU1 C2   C N N 82  
BU1 C3   C N N 83  
BU1 C4   C N N 84  
BU1 O5   O N N 85  
BU1 O6   O N N 86  
BU1 H11  H N N 87  
BU1 H12  H N N 88  
BU1 H21  H N N 89  
BU1 H22  H N N 90  
BU1 H31  H N N 91  
BU1 H32  H N N 92  
BU1 H41  H N N 93  
BU1 H42  H N N 94  
BU1 HO5  H N N 95  
BU1 HO6  H N N 96  
CYS N    N N N 97  
CYS CA   C N R 98  
CYS C    C N N 99  
CYS O    O N N 100 
CYS CB   C N N 101 
CYS SG   S N N 102 
CYS OXT  O N N 103 
CYS H    H N N 104 
CYS H2   H N N 105 
CYS HA   H N N 106 
CYS HB2  H N N 107 
CYS HB3  H N N 108 
CYS HG   H N N 109 
CYS HXT  H N N 110 
GLN N    N N N 111 
GLN CA   C N S 112 
GLN C    C N N 113 
GLN O    O N N 114 
GLN CB   C N N 115 
GLN CG   C N N 116 
GLN CD   C N N 117 
GLN OE1  O N N 118 
GLN NE2  N N N 119 
GLN OXT  O N N 120 
GLN H    H N N 121 
GLN H2   H N N 122 
GLN HA   H N N 123 
GLN HB2  H N N 124 
GLN HB3  H N N 125 
GLN HG2  H N N 126 
GLN HG3  H N N 127 
GLN HE21 H N N 128 
GLN HE22 H N N 129 
GLN HXT  H N N 130 
GLU N    N N N 131 
GLU CA   C N S 132 
GLU C    C N N 133 
GLU O    O N N 134 
GLU CB   C N N 135 
GLU CG   C N N 136 
GLU CD   C N N 137 
GLU OE1  O N N 138 
GLU OE2  O N N 139 
GLU OXT  O N N 140 
GLU H    H N N 141 
GLU H2   H N N 142 
GLU HA   H N N 143 
GLU HB2  H N N 144 
GLU HB3  H N N 145 
GLU HG2  H N N 146 
GLU HG3  H N N 147 
GLU HE2  H N N 148 
GLU HXT  H N N 149 
GLY N    N N N 150 
GLY CA   C N N 151 
GLY C    C N N 152 
GLY O    O N N 153 
GLY OXT  O N N 154 
GLY H    H N N 155 
GLY H2   H N N 156 
GLY HA2  H N N 157 
GLY HA3  H N N 158 
GLY HXT  H N N 159 
HIS N    N N N 160 
HIS CA   C N S 161 
HIS C    C N N 162 
HIS O    O N N 163 
HIS CB   C N N 164 
HIS CG   C Y N 165 
HIS ND1  N Y N 166 
HIS CD2  C Y N 167 
HIS CE1  C Y N 168 
HIS NE2  N Y N 169 
HIS OXT  O N N 170 
HIS H    H N N 171 
HIS H2   H N N 172 
HIS HA   H N N 173 
HIS HB2  H N N 174 
HIS HB3  H N N 175 
HIS HD1  H N N 176 
HIS HD2  H N N 177 
HIS HE1  H N N 178 
HIS HE2  H N N 179 
HIS HXT  H N N 180 
HOH O    O N N 181 
HOH H1   H N N 182 
HOH H2   H N N 183 
ILE N    N N N 184 
ILE CA   C N S 185 
ILE C    C N N 186 
ILE O    O N N 187 
ILE CB   C N S 188 
ILE CG1  C N N 189 
ILE CG2  C N N 190 
ILE CD1  C N N 191 
ILE OXT  O N N 192 
ILE H    H N N 193 
ILE H2   H N N 194 
ILE HA   H N N 195 
ILE HB   H N N 196 
ILE HG12 H N N 197 
ILE HG13 H N N 198 
ILE HG21 H N N 199 
ILE HG22 H N N 200 
ILE HG23 H N N 201 
ILE HD11 H N N 202 
ILE HD12 H N N 203 
ILE HD13 H N N 204 
ILE HXT  H N N 205 
LEU N    N N N 206 
LEU CA   C N S 207 
LEU C    C N N 208 
LEU O    O N N 209 
LEU CB   C N N 210 
LEU CG   C N N 211 
LEU CD1  C N N 212 
LEU CD2  C N N 213 
LEU OXT  O N N 214 
LEU H    H N N 215 
LEU H2   H N N 216 
LEU HA   H N N 217 
LEU HB2  H N N 218 
LEU HB3  H N N 219 
LEU HG   H N N 220 
LEU HD11 H N N 221 
LEU HD12 H N N 222 
LEU HD13 H N N 223 
LEU HD21 H N N 224 
LEU HD22 H N N 225 
LEU HD23 H N N 226 
LEU HXT  H N N 227 
LYS N    N N N 228 
LYS CA   C N S 229 
LYS C    C N N 230 
LYS O    O N N 231 
LYS CB   C N N 232 
LYS CG   C N N 233 
LYS CD   C N N 234 
LYS CE   C N N 235 
LYS NZ   N N N 236 
LYS OXT  O N N 237 
LYS H    H N N 238 
LYS H2   H N N 239 
LYS HA   H N N 240 
LYS HB2  H N N 241 
LYS HB3  H N N 242 
LYS HG2  H N N 243 
LYS HG3  H N N 244 
LYS HD2  H N N 245 
LYS HD3  H N N 246 
LYS HE2  H N N 247 
LYS HE3  H N N 248 
LYS HZ1  H N N 249 
LYS HZ2  H N N 250 
LYS HZ3  H N N 251 
LYS HXT  H N N 252 
MET N    N N N 253 
MET CA   C N S 254 
MET C    C N N 255 
MET O    O N N 256 
MET CB   C N N 257 
MET CG   C N N 258 
MET SD   S N N 259 
MET CE   C N N 260 
MET OXT  O N N 261 
MET H    H N N 262 
MET H2   H N N 263 
MET HA   H N N 264 
MET HB2  H N N 265 
MET HB3  H N N 266 
MET HG2  H N N 267 
MET HG3  H N N 268 
MET HE1  H N N 269 
MET HE2  H N N 270 
MET HE3  H N N 271 
MET HXT  H N N 272 
MK8 C    C N N 273 
MK8 N    N N N 274 
MK8 O    O N N 275 
MK8 CA   C N S 276 
MK8 CB   C N N 277 
MK8 CD   C N N 278 
MK8 CE   C N N 279 
MK8 CG   C N N 280 
MK8 CB1  C N N 281 
MK8 OXT  O N N 282 
MK8 H    H N N 283 
MK8 H2   H N N 284 
MK8 HB   H N N 285 
MK8 HBA  H N N 286 
MK8 HD   H N N 287 
MK8 HDA  H N N 288 
MK8 HE   H N N 289 
MK8 HEA  H N N 290 
MK8 HEB  H N N 291 
MK8 HG   H N N 292 
MK8 HGA  H N N 293 
MK8 HB1  H N N 294 
MK8 HB1A H N N 295 
MK8 HB1B H N N 296 
MK8 HXT  H N N 297 
NH2 N    N N N 298 
NH2 HN1  H N N 299 
NH2 HN2  H N N 300 
NLE N    N N N 301 
NLE CA   C N S 302 
NLE C    C N N 303 
NLE O    O N N 304 
NLE OXT  O N N 305 
NLE CB   C N N 306 
NLE CG   C N N 307 
NLE CD   C N N 308 
NLE CE   C N N 309 
NLE H    H N N 310 
NLE H2   H N N 311 
NLE HA   H N N 312 
NLE HXT  H N N 313 
NLE HB2  H N N 314 
NLE HB3  H N N 315 
NLE HG2  H N N 316 
NLE HG3  H N N 317 
NLE HD2  H N N 318 
NLE HD3  H N N 319 
NLE HE1  H N N 320 
NLE HE2  H N N 321 
NLE HE3  H N N 322 
PHE N    N N N 323 
PHE CA   C N S 324 
PHE C    C N N 325 
PHE O    O N N 326 
PHE CB   C N N 327 
PHE CG   C Y N 328 
PHE CD1  C Y N 329 
PHE CD2  C Y N 330 
PHE CE1  C Y N 331 
PHE CE2  C Y N 332 
PHE CZ   C Y N 333 
PHE OXT  O N N 334 
PHE H    H N N 335 
PHE H2   H N N 336 
PHE HA   H N N 337 
PHE HB2  H N N 338 
PHE HB3  H N N 339 
PHE HD1  H N N 340 
PHE HD2  H N N 341 
PHE HE1  H N N 342 
PHE HE2  H N N 343 
PHE HZ   H N N 344 
PHE HXT  H N N 345 
PRO N    N N N 346 
PRO CA   C N S 347 
PRO C    C N N 348 
PRO O    O N N 349 
PRO CB   C N N 350 
PRO CG   C N N 351 
PRO CD   C N N 352 
PRO OXT  O N N 353 
PRO H    H N N 354 
PRO HA   H N N 355 
PRO HB2  H N N 356 
PRO HB3  H N N 357 
PRO HG2  H N N 358 
PRO HG3  H N N 359 
PRO HD2  H N N 360 
PRO HD3  H N N 361 
PRO HXT  H N N 362 
SER N    N N N 363 
SER CA   C N S 364 
SER C    C N N 365 
SER O    O N N 366 
SER CB   C N N 367 
SER OG   O N N 368 
SER OXT  O N N 369 
SER H    H N N 370 
SER H2   H N N 371 
SER HA   H N N 372 
SER HB2  H N N 373 
SER HB3  H N N 374 
SER HG   H N N 375 
SER HXT  H N N 376 
THR N    N N N 377 
THR CA   C N S 378 
THR C    C N N 379 
THR O    O N N 380 
THR CB   C N R 381 
THR OG1  O N N 382 
THR CG2  C N N 383 
THR OXT  O N N 384 
THR H    H N N 385 
THR H2   H N N 386 
THR HA   H N N 387 
THR HB   H N N 388 
THR HG1  H N N 389 
THR HG21 H N N 390 
THR HG22 H N N 391 
THR HG23 H N N 392 
THR HXT  H N N 393 
TRP N    N N N 394 
TRP CA   C N S 395 
TRP C    C N N 396 
TRP O    O N N 397 
TRP CB   C N N 398 
TRP CG   C Y N 399 
TRP CD1  C Y N 400 
TRP CD2  C Y N 401 
TRP NE1  N Y N 402 
TRP CE2  C Y N 403 
TRP CE3  C Y N 404 
TRP CZ2  C Y N 405 
TRP CZ3  C Y N 406 
TRP CH2  C Y N 407 
TRP OXT  O N N 408 
TRP H    H N N 409 
TRP H2   H N N 410 
TRP HA   H N N 411 
TRP HB2  H N N 412 
TRP HB3  H N N 413 
TRP HD1  H N N 414 
TRP HE1  H N N 415 
TRP HE3  H N N 416 
TRP HZ2  H N N 417 
TRP HZ3  H N N 418 
TRP HH2  H N N 419 
TRP HXT  H N N 420 
TYR N    N N N 421 
TYR CA   C N S 422 
TYR C    C N N 423 
TYR O    O N N 424 
TYR CB   C N N 425 
TYR CG   C Y N 426 
TYR CD1  C Y N 427 
TYR CD2  C Y N 428 
TYR CE1  C Y N 429 
TYR CE2  C Y N 430 
TYR CZ   C Y N 431 
TYR OH   O N N 432 
TYR OXT  O N N 433 
TYR H    H N N 434 
TYR H2   H N N 435 
TYR HA   H N N 436 
TYR HB2  H N N 437 
TYR HB3  H N N 438 
TYR HD1  H N N 439 
TYR HD2  H N N 440 
TYR HE1  H N N 441 
TYR HE2  H N N 442 
TYR HH   H N N 443 
TYR HXT  H N N 444 
VAL N    N N N 445 
VAL CA   C N S 446 
VAL C    C N N 447 
VAL O    O N N 448 
VAL CB   C N N 449 
VAL CG1  C N N 450 
VAL CG2  C N N 451 
VAL OXT  O N N 452 
VAL H    H N N 453 
VAL H2   H N N 454 
VAL HA   H N N 455 
VAL HB   H N N 456 
VAL HG11 H N N 457 
VAL HG12 H N N 458 
VAL HG13 H N N 459 
VAL HG21 H N N 460 
VAL HG22 H N N 461 
VAL HG23 H N N 462 
VAL HXT  H N N 463 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACE C   O    doub N N 1   
ACE C   CH3  sing N N 2   
ACE C   H    sing N N 3   
ACE CH3 H1   sing N N 4   
ACE CH3 H2   sing N N 5   
ACE CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
BU1 C1  C2   sing N N 76  
BU1 C1  O5   sing N N 77  
BU1 C1  H11  sing N N 78  
BU1 C1  H12  sing N N 79  
BU1 C2  C3   sing N N 80  
BU1 C2  H21  sing N N 81  
BU1 C2  H22  sing N N 82  
BU1 C3  C4   sing N N 83  
BU1 C3  H31  sing N N 84  
BU1 C3  H32  sing N N 85  
BU1 C4  O6   sing N N 86  
BU1 C4  H41  sing N N 87  
BU1 C4  H42  sing N N 88  
BU1 O5  HO5  sing N N 89  
BU1 O6  HO6  sing N N 90  
CYS N   CA   sing N N 91  
CYS N   H    sing N N 92  
CYS N   H2   sing N N 93  
CYS CA  C    sing N N 94  
CYS CA  CB   sing N N 95  
CYS CA  HA   sing N N 96  
CYS C   O    doub N N 97  
CYS C   OXT  sing N N 98  
CYS CB  SG   sing N N 99  
CYS CB  HB2  sing N N 100 
CYS CB  HB3  sing N N 101 
CYS SG  HG   sing N N 102 
CYS OXT HXT  sing N N 103 
GLN N   CA   sing N N 104 
GLN N   H    sing N N 105 
GLN N   H2   sing N N 106 
GLN CA  C    sing N N 107 
GLN CA  CB   sing N N 108 
GLN CA  HA   sing N N 109 
GLN C   O    doub N N 110 
GLN C   OXT  sing N N 111 
GLN CB  CG   sing N N 112 
GLN CB  HB2  sing N N 113 
GLN CB  HB3  sing N N 114 
GLN CG  CD   sing N N 115 
GLN CG  HG2  sing N N 116 
GLN CG  HG3  sing N N 117 
GLN CD  OE1  doub N N 118 
GLN CD  NE2  sing N N 119 
GLN NE2 HE21 sing N N 120 
GLN NE2 HE22 sing N N 121 
GLN OXT HXT  sing N N 122 
GLU N   CA   sing N N 123 
GLU N   H    sing N N 124 
GLU N   H2   sing N N 125 
GLU CA  C    sing N N 126 
GLU CA  CB   sing N N 127 
GLU CA  HA   sing N N 128 
GLU C   O    doub N N 129 
GLU C   OXT  sing N N 130 
GLU CB  CG   sing N N 131 
GLU CB  HB2  sing N N 132 
GLU CB  HB3  sing N N 133 
GLU CG  CD   sing N N 134 
GLU CG  HG2  sing N N 135 
GLU CG  HG3  sing N N 136 
GLU CD  OE1  doub N N 137 
GLU CD  OE2  sing N N 138 
GLU OE2 HE2  sing N N 139 
GLU OXT HXT  sing N N 140 
GLY N   CA   sing N N 141 
GLY N   H    sing N N 142 
GLY N   H2   sing N N 143 
GLY CA  C    sing N N 144 
GLY CA  HA2  sing N N 145 
GLY CA  HA3  sing N N 146 
GLY C   O    doub N N 147 
GLY C   OXT  sing N N 148 
GLY OXT HXT  sing N N 149 
HIS N   CA   sing N N 150 
HIS N   H    sing N N 151 
HIS N   H2   sing N N 152 
HIS CA  C    sing N N 153 
HIS CA  CB   sing N N 154 
HIS CA  HA   sing N N 155 
HIS C   O    doub N N 156 
HIS C   OXT  sing N N 157 
HIS CB  CG   sing N N 158 
HIS CB  HB2  sing N N 159 
HIS CB  HB3  sing N N 160 
HIS CG  ND1  sing Y N 161 
HIS CG  CD2  doub Y N 162 
HIS ND1 CE1  doub Y N 163 
HIS ND1 HD1  sing N N 164 
HIS CD2 NE2  sing Y N 165 
HIS CD2 HD2  sing N N 166 
HIS CE1 NE2  sing Y N 167 
HIS CE1 HE1  sing N N 168 
HIS NE2 HE2  sing N N 169 
HIS OXT HXT  sing N N 170 
HOH O   H1   sing N N 171 
HOH O   H2   sing N N 172 
ILE N   CA   sing N N 173 
ILE N   H    sing N N 174 
ILE N   H2   sing N N 175 
ILE CA  C    sing N N 176 
ILE CA  CB   sing N N 177 
ILE CA  HA   sing N N 178 
ILE C   O    doub N N 179 
ILE C   OXT  sing N N 180 
ILE CB  CG1  sing N N 181 
ILE CB  CG2  sing N N 182 
ILE CB  HB   sing N N 183 
ILE CG1 CD1  sing N N 184 
ILE CG1 HG12 sing N N 185 
ILE CG1 HG13 sing N N 186 
ILE CG2 HG21 sing N N 187 
ILE CG2 HG22 sing N N 188 
ILE CG2 HG23 sing N N 189 
ILE CD1 HD11 sing N N 190 
ILE CD1 HD12 sing N N 191 
ILE CD1 HD13 sing N N 192 
ILE OXT HXT  sing N N 193 
LEU N   CA   sing N N 194 
LEU N   H    sing N N 195 
LEU N   H2   sing N N 196 
LEU CA  C    sing N N 197 
LEU CA  CB   sing N N 198 
LEU CA  HA   sing N N 199 
LEU C   O    doub N N 200 
LEU C   OXT  sing N N 201 
LEU CB  CG   sing N N 202 
LEU CB  HB2  sing N N 203 
LEU CB  HB3  sing N N 204 
LEU CG  CD1  sing N N 205 
LEU CG  CD2  sing N N 206 
LEU CG  HG   sing N N 207 
LEU CD1 HD11 sing N N 208 
LEU CD1 HD12 sing N N 209 
LEU CD1 HD13 sing N N 210 
LEU CD2 HD21 sing N N 211 
LEU CD2 HD22 sing N N 212 
LEU CD2 HD23 sing N N 213 
LEU OXT HXT  sing N N 214 
LYS N   CA   sing N N 215 
LYS N   H    sing N N 216 
LYS N   H2   sing N N 217 
LYS CA  C    sing N N 218 
LYS CA  CB   sing N N 219 
LYS CA  HA   sing N N 220 
LYS C   O    doub N N 221 
LYS C   OXT  sing N N 222 
LYS CB  CG   sing N N 223 
LYS CB  HB2  sing N N 224 
LYS CB  HB3  sing N N 225 
LYS CG  CD   sing N N 226 
LYS CG  HG2  sing N N 227 
LYS CG  HG3  sing N N 228 
LYS CD  CE   sing N N 229 
LYS CD  HD2  sing N N 230 
LYS CD  HD3  sing N N 231 
LYS CE  NZ   sing N N 232 
LYS CE  HE2  sing N N 233 
LYS CE  HE3  sing N N 234 
LYS NZ  HZ1  sing N N 235 
LYS NZ  HZ2  sing N N 236 
LYS NZ  HZ3  sing N N 237 
LYS OXT HXT  sing N N 238 
MET N   CA   sing N N 239 
MET N   H    sing N N 240 
MET N   H2   sing N N 241 
MET CA  C    sing N N 242 
MET CA  CB   sing N N 243 
MET CA  HA   sing N N 244 
MET C   O    doub N N 245 
MET C   OXT  sing N N 246 
MET CB  CG   sing N N 247 
MET CB  HB2  sing N N 248 
MET CB  HB3  sing N N 249 
MET CG  SD   sing N N 250 
MET CG  HG2  sing N N 251 
MET CG  HG3  sing N N 252 
MET SD  CE   sing N N 253 
MET CE  HE1  sing N N 254 
MET CE  HE2  sing N N 255 
MET CE  HE3  sing N N 256 
MET OXT HXT  sing N N 257 
MK8 C   CA   sing N N 258 
MK8 C   OXT  sing N N 259 
MK8 N   H    sing N N 260 
MK8 N   H2   sing N N 261 
MK8 O   C    doub N N 262 
MK8 CA  N    sing N N 263 
MK8 CA  CB   sing N N 264 
MK8 CB  HB   sing N N 265 
MK8 CB  HBA  sing N N 266 
MK8 CD  CG   sing N N 267 
MK8 CD  HD   sing N N 268 
MK8 CD  HDA  sing N N 269 
MK8 CE  CD   sing N N 270 
MK8 CE  HE   sing N N 271 
MK8 CE  HEA  sing N N 272 
MK8 CE  HEB  sing N N 273 
MK8 CG  CB   sing N N 274 
MK8 CG  HG   sing N N 275 
MK8 CG  HGA  sing N N 276 
MK8 CB1 CA   sing N N 277 
MK8 CB1 HB1  sing N N 278 
MK8 CB1 HB1A sing N N 279 
MK8 CB1 HB1B sing N N 280 
MK8 OXT HXT  sing N N 281 
NH2 N   HN1  sing N N 282 
NH2 N   HN2  sing N N 283 
NLE N   CA   sing N N 284 
NLE N   H    sing N N 285 
NLE N   H2   sing N N 286 
NLE CA  C    sing N N 287 
NLE CA  CB   sing N N 288 
NLE CA  HA   sing N N 289 
NLE C   O    doub N N 290 
NLE C   OXT  sing N N 291 
NLE OXT HXT  sing N N 292 
NLE CB  CG   sing N N 293 
NLE CB  HB2  sing N N 294 
NLE CB  HB3  sing N N 295 
NLE CG  CD   sing N N 296 
NLE CG  HG2  sing N N 297 
NLE CG  HG3  sing N N 298 
NLE CD  CE   sing N N 299 
NLE CD  HD2  sing N N 300 
NLE CD  HD3  sing N N 301 
NLE CE  HE1  sing N N 302 
NLE CE  HE2  sing N N 303 
NLE CE  HE3  sing N N 304 
PHE N   CA   sing N N 305 
PHE N   H    sing N N 306 
PHE N   H2   sing N N 307 
PHE CA  C    sing N N 308 
PHE CA  CB   sing N N 309 
PHE CA  HA   sing N N 310 
PHE C   O    doub N N 311 
PHE C   OXT  sing N N 312 
PHE CB  CG   sing N N 313 
PHE CB  HB2  sing N N 314 
PHE CB  HB3  sing N N 315 
PHE CG  CD1  doub Y N 316 
PHE CG  CD2  sing Y N 317 
PHE CD1 CE1  sing Y N 318 
PHE CD1 HD1  sing N N 319 
PHE CD2 CE2  doub Y N 320 
PHE CD2 HD2  sing N N 321 
PHE CE1 CZ   doub Y N 322 
PHE CE1 HE1  sing N N 323 
PHE CE2 CZ   sing Y N 324 
PHE CE2 HE2  sing N N 325 
PHE CZ  HZ   sing N N 326 
PHE OXT HXT  sing N N 327 
PRO N   CA   sing N N 328 
PRO N   CD   sing N N 329 
PRO N   H    sing N N 330 
PRO CA  C    sing N N 331 
PRO CA  CB   sing N N 332 
PRO CA  HA   sing N N 333 
PRO C   O    doub N N 334 
PRO C   OXT  sing N N 335 
PRO CB  CG   sing N N 336 
PRO CB  HB2  sing N N 337 
PRO CB  HB3  sing N N 338 
PRO CG  CD   sing N N 339 
PRO CG  HG2  sing N N 340 
PRO CG  HG3  sing N N 341 
PRO CD  HD2  sing N N 342 
PRO CD  HD3  sing N N 343 
PRO OXT HXT  sing N N 344 
SER N   CA   sing N N 345 
SER N   H    sing N N 346 
SER N   H2   sing N N 347 
SER CA  C    sing N N 348 
SER CA  CB   sing N N 349 
SER CA  HA   sing N N 350 
SER C   O    doub N N 351 
SER C   OXT  sing N N 352 
SER CB  OG   sing N N 353 
SER CB  HB2  sing N N 354 
SER CB  HB3  sing N N 355 
SER OG  HG   sing N N 356 
SER OXT HXT  sing N N 357 
THR N   CA   sing N N 358 
THR N   H    sing N N 359 
THR N   H2   sing N N 360 
THR CA  C    sing N N 361 
THR CA  CB   sing N N 362 
THR CA  HA   sing N N 363 
THR C   O    doub N N 364 
THR C   OXT  sing N N 365 
THR CB  OG1  sing N N 366 
THR CB  CG2  sing N N 367 
THR CB  HB   sing N N 368 
THR OG1 HG1  sing N N 369 
THR CG2 HG21 sing N N 370 
THR CG2 HG22 sing N N 371 
THR CG2 HG23 sing N N 372 
THR OXT HXT  sing N N 373 
TRP N   CA   sing N N 374 
TRP N   H    sing N N 375 
TRP N   H2   sing N N 376 
TRP CA  C    sing N N 377 
TRP CA  CB   sing N N 378 
TRP CA  HA   sing N N 379 
TRP C   O    doub N N 380 
TRP C   OXT  sing N N 381 
TRP CB  CG   sing N N 382 
TRP CB  HB2  sing N N 383 
TRP CB  HB3  sing N N 384 
TRP CG  CD1  doub Y N 385 
TRP CG  CD2  sing Y N 386 
TRP CD1 NE1  sing Y N 387 
TRP CD1 HD1  sing N N 388 
TRP CD2 CE2  doub Y N 389 
TRP CD2 CE3  sing Y N 390 
TRP NE1 CE2  sing Y N 391 
TRP NE1 HE1  sing N N 392 
TRP CE2 CZ2  sing Y N 393 
TRP CE3 CZ3  doub Y N 394 
TRP CE3 HE3  sing N N 395 
TRP CZ2 CH2  doub Y N 396 
TRP CZ2 HZ2  sing N N 397 
TRP CZ3 CH2  sing Y N 398 
TRP CZ3 HZ3  sing N N 399 
TRP CH2 HH2  sing N N 400 
TRP OXT HXT  sing N N 401 
TYR N   CA   sing N N 402 
TYR N   H    sing N N 403 
TYR N   H2   sing N N 404 
TYR CA  C    sing N N 405 
TYR CA  CB   sing N N 406 
TYR CA  HA   sing N N 407 
TYR C   O    doub N N 408 
TYR C   OXT  sing N N 409 
TYR CB  CG   sing N N 410 
TYR CB  HB2  sing N N 411 
TYR CB  HB3  sing N N 412 
TYR CG  CD1  doub Y N 413 
TYR CG  CD2  sing Y N 414 
TYR CD1 CE1  sing Y N 415 
TYR CD1 HD1  sing N N 416 
TYR CD2 CE2  doub Y N 417 
TYR CD2 HD2  sing N N 418 
TYR CE1 CZ   doub Y N 419 
TYR CE1 HE1  sing N N 420 
TYR CE2 CZ   sing Y N 421 
TYR CE2 HE2  sing N N 422 
TYR CZ  OH   sing N N 423 
TYR OH  HH   sing N N 424 
TYR OXT HXT  sing N N 425 
VAL N   CA   sing N N 426 
VAL N   H    sing N N 427 
VAL N   H2   sing N N 428 
VAL CA  C    sing N N 429 
VAL CA  CB   sing N N 430 
VAL CA  HA   sing N N 431 
VAL C   O    doub N N 432 
VAL C   OXT  sing N N 433 
VAL CB  CG1  sing N N 434 
VAL CB  CG2  sing N N 435 
VAL CB  HB   sing N N 436 
VAL CG1 HG11 sing N N 437 
VAL CG1 HG12 sing N N 438 
VAL CG1 HG13 sing N N 439 
VAL CG2 HG21 sing N N 440 
VAL CG2 HG22 sing N N 441 
VAL CG2 HG23 sing N N 442 
VAL OXT HXT  sing N N 443 
# 
_pdbx_audit_support.funding_organization   'H2020 Marie Curie Actions of the European Commission' 
_pdbx_audit_support.country                'European Union' 
_pdbx_audit_support.grant_number           HORIZON-MSCA-2021-PF-01-101061526 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5ONA 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_related_exp_data_set.ordinal              1 
_pdbx_related_exp_data_set.data_reference       10.15151/ESRF-ES-893681931 
_pdbx_related_exp_data_set.metadata_reference   ? 
_pdbx_related_exp_data_set.data_set_type        'diffraction image data' 
_pdbx_related_exp_data_set.details              ? 
# 
_atom_sites.entry_id                    9FL8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009384 
_atom_sites.fract_transf_matrix[1][2]   0.005418 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010836 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003808 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LEU A 1 2   ? -21.458 38.819  -93.376  1.00 48.50  ? 17   LEU G N   1 
ATOM   2    C CA  . LEU A 1 2   ? -22.828 39.209  -93.068  1.00 59.75  ? 17   LEU G CA  1 
ATOM   3    C C   . LEU A 1 2   ? -23.411 40.084  -94.171  1.00 74.12  ? 17   LEU G C   1 
ATOM   4    O O   . LEU A 1 2   ? -24.553 39.887  -94.587  1.00 77.41  ? 17   LEU G O   1 
ATOM   5    C CB  . LEU A 1 2   ? -22.893 39.942  -91.722  1.00 61.88  ? 17   LEU G CB  1 
ATOM   6    C CG  . LEU A 1 2   ? -24.269 40.419  -91.238  1.00 54.93  ? 17   LEU G CG  1 
ATOM   7    C CD1 . LEU A 1 2   ? -24.380 40.277  -89.729  1.00 47.45  ? 17   LEU G CD1 1 
ATOM   8    C CD2 . LEU A 1 2   ? -24.553 41.863  -91.652  1.00 54.78  ? 17   LEU G CD2 1 
ATOM   9    N N   . ASP A 1 3   ? -22.618 41.051  -94.628  1.00 84.16  ? 18   ASP G N   1 
ATOM   10   C CA  . ASP A 1 3   ? -23.064 42.046  -95.604  1.00 82.27  ? 18   ASP G CA  1 
ATOM   11   C C   . ASP A 1 3   ? -23.684 41.407  -96.844  1.00 77.63  ? 18   ASP G C   1 
ATOM   12   O O   . ASP A 1 3   ? -24.723 41.865  -97.329  1.00 73.03  ? 18   ASP G O   1 
ATOM   13   C CB  . ASP A 1 3   ? -21.896 42.948  -96.007  1.00 69.88  ? 18   ASP G CB  1 
ATOM   14   C CG  . ASP A 1 3   ? -21.132 43.477  -94.809  1.00 86.72  ? 18   ASP G CG  1 
ATOM   15   O OD1 . ASP A 1 3   ? -20.329 42.714  -94.228  1.00 81.09  ? 18   ASP G OD1 1 
ATOM   16   O OD2 . ASP A 1 3   ? -21.337 44.654  -94.446  1.00 92.61  ? 18   ASP G OD2 1 
HETATM 17   C C   . MK8 A 1 4   ? -24.996 39.061  -98.112  1.00 67.78  ? 19   MK8 G C   1 
HETATM 18   N N   . MK8 A 1 4   ? -23.037 40.353  -97.339  1.00 68.34  ? 19   MK8 G N   1 
HETATM 19   O O   . MK8 A 1 4   ? -25.906 39.367  -98.909  1.00 75.54  ? 19   MK8 G O   1 
HETATM 20   C CA  . MK8 A 1 4   ? -23.560 39.517  -98.454  1.00 51.73  ? 19   MK8 G CA  1 
HETATM 21   C CB  . MK8 A 1 4   ? -22.625 38.312  -98.704  1.00 49.73  ? 19   MK8 G CB  1 
HETATM 22   C CD  . MK8 A 1 4   ? -23.945 36.959  -100.465 1.00 43.82  ? 19   MK8 G CD  1 
HETATM 23   C CE  . MK8 A 1 4   ? -24.722 35.684  -100.687 1.00 45.62  ? 19   MK8 G CE  1 
HETATM 24   C CG  . MK8 A 1 4   ? -23.256 36.990  -99.125  1.00 52.59  ? 19   MK8 G CG  1 
HETATM 25   C CB1 . MK8 A 1 4   ? -23.594 40.375  -99.719  1.00 47.75  ? 19   MK8 G CB1 1 
ATOM   26   N N   . ASN A 1 5   ? -25.188 38.380  -96.987  1.00 76.07  ? 20   ASN G N   1 
ATOM   27   C CA  . ASN A 1 5   ? -26.504 37.879  -96.606  1.00 59.79  ? 20   ASN G CA  1 
ATOM   28   C C   . ASN A 1 5   ? -27.456 39.028  -96.286  1.00 61.30  ? 20   ASN G C   1 
ATOM   29   O O   . ASN A 1 5   ? -28.662 38.932  -96.517  1.00 65.45  ? 20   ASN G O   1 
ATOM   30   C CB  . ASN A 1 5   ? -26.383 36.937  -95.410  1.00 54.58  ? 20   ASN G CB  1 
ATOM   31   C CG  . ASN A 1 5   ? -25.159 36.049  -95.493  1.00 65.22  ? 20   ASN G CG  1 
ATOM   32   O OD1 . ASN A 1 5   ? -24.140 36.316  -94.853  1.00 71.98  ? 20   ASN G OD1 1 
ATOM   33   N ND2 . ASN A 1 5   ? -25.250 34.987  -96.285  1.00 54.10  ? 20   ASN G ND2 1 
ATOM   34   N N   . PHE A 1 6   ? -26.899 40.118  -95.752  1.00 53.77  ? 21   PHE G N   1 
ATOM   35   C CA  . PHE A 1 6   ? -27.707 41.302  -95.482  1.00 49.54  ? 21   PHE G CA  1 
ATOM   36   C C   . PHE A 1 6   ? -28.266 41.891  -96.771  1.00 57.84  ? 21   PHE G C   1 
ATOM   37   O O   . PHE A 1 6   ? -29.440 42.273  -96.831  1.00 59.20  ? 21   PHE G O   1 
ATOM   38   C CB  . PHE A 1 6   ? -26.875 42.343  -94.734  1.00 53.70  ? 21   PHE G CB  1 
ATOM   39   C CG  . PHE A 1 6   ? -27.689 43.453  -94.138  1.00 65.85  ? 21   PHE G CG  1 
ATOM   40   C CD1 . PHE A 1 6   ? -28.586 43.198  -93.115  1.00 57.91  ? 21   PHE G CD1 1 
ATOM   41   C CD2 . PHE A 1 6   ? -27.555 44.753  -94.597  1.00 68.42  ? 21   PHE G CD2 1 
ATOM   42   C CE1 . PHE A 1 6   ? -29.336 44.216  -92.562  1.00 52.64  ? 21   PHE G CE1 1 
ATOM   43   C CE2 . PHE A 1 6   ? -28.301 45.775  -94.044  1.00 67.43  ? 21   PHE G CE2 1 
ATOM   44   C CZ  . PHE A 1 6   ? -29.193 45.504  -93.028  1.00 62.04  ? 21   PHE G CZ  1 
ATOM   45   N N   . LYS A 1 7   ? -27.441 41.968  -97.811  1.00 58.61  ? 22   LYS G N   1 
ATOM   46   C CA  . LYS A 1 7   ? -27.871 42.494  -99.102  1.00 57.52  ? 22   LYS G CA  1 
ATOM   47   C C   . LYS A 1 7   ? -28.941 41.597  -99.713  1.00 55.53  ? 22   LYS G C   1 
ATOM   48   O O   . LYS A 1 7   ? -30.028 42.062  -100.059 1.00 59.17  ? 22   LYS G O   1 
ATOM   49   C CB  . LYS A 1 7   ? -26.680 42.622  -100.059 1.00 53.97  ? 22   LYS G CB  1 
ATOM   50   C CG  . LYS A 1 7   ? -26.133 44.040  -100.214 1.00 82.15  ? 22   LYS G CG  1 
ATOM   51   C CD  . LYS A 1 7   ? -26.118 44.791  -98.886  1.00 89.99  ? 22   LYS G CD  1 
ATOM   52   C CE  . LYS A 1 7   ? -25.301 46.072  -98.971  1.00 63.30  ? 22   LYS G CE  1 
ATOM   53   N NZ  . LYS A 1 7   ? -25.213 46.753  -97.648  1.00 49.50  ? 22   LYS G NZ  1 
HETATM 54   C C   . MK8 A 1 8   ? -30.882 39.282  -99.668  1.00 51.29  ? 23   MK8 G C   1 
HETATM 55   N N   . MK8 A 1 8   ? -28.614 40.311  -99.830  1.00 54.65  ? 23   MK8 G N   1 
HETATM 56   O O   . MK8 A 1 8   ? -31.914 39.290  -100.371 1.00 47.97  ? 23   MK8 G O   1 
HETATM 57   C CA  . MK8 A 1 8   ? -29.520 39.274  -100.399 1.00 44.07  ? 23   MK8 G CA  1 
HETATM 58   C CB  . MK8 A 1 8   ? -28.848 37.886  -100.320 1.00 28.17  ? 23   MK8 G CB  1 
HETATM 59   C CD  . MK8 A 1 8   ? -27.113 36.247  -101.274 1.00 41.07  ? 23   MK8 G CD  1 
HETATM 60   C CE  . MK8 A 1 8   ? -26.052 36.060  -100.217 1.00 43.74  ? 23   MK8 G CE  1 
HETATM 61   C CG  . MK8 A 1 8   ? -27.730 37.621  -101.320 1.00 37.12  ? 23   MK8 G CG  1 
HETATM 62   C CB1 . MK8 A 1 8   ? -29.742 39.589  -101.879 1.00 47.54  ? 23   MK8 G CB1 1 
HETATM 63   N N   . NLE A 1 9   ? -30.889 39.301  -98.339  1.00 50.42  ? 24   NLE G N   1 
HETATM 64   C CA  . NLE A 1 9   ? -32.142 39.331  -97.592  1.00 53.11  ? 24   NLE G CA  1 
HETATM 65   C C   . NLE A 1 9   ? -32.947 40.595  -97.901  1.00 50.45  ? 24   NLE G C   1 
HETATM 66   O O   . NLE A 1 9   ? -34.174 40.548  -97.995  1.00 55.23  ? 24   NLE G O   1 
HETATM 67   C CB  . NLE A 1 9   ? -31.876 39.229  -96.088  1.00 49.93  ? 24   NLE G CB  1 
HETATM 68   C CG  . NLE A 1 9   ? -33.120 39.391  -95.222  1.00 55.42  ? 24   NLE G CG  1 
HETATM 69   C CD  . NLE A 1 9   ? -34.141 38.286  -95.472  1.00 45.90  ? 24   NLE G CD  1 
HETATM 70   C CE  . NLE A 1 9   ? -33.720 36.979  -94.817  1.00 50.24  ? 24   NLE G CE  1 
ATOM   71   N N   . GLU A 1 10  ? -32.253 41.718  -98.064  1.00 44.34  ? 25   GLU G N   1 
ATOM   72   C CA  . GLU A 1 10  ? -32.911 42.985  -98.367  1.00 29.38  ? 25   GLU G CA  1 
ATOM   73   C C   . GLU A 1 10  ? -33.622 42.918  -99.718  1.00 42.91  ? 25   GLU G C   1 
ATOM   74   O O   . GLU A 1 10  ? -34.714 43.467  -99.881  1.00 44.03  ? 25   GLU G O   1 
ATOM   75   C CB  . GLU A 1 10  ? -31.901 44.135  -98.356  1.00 53.20  ? 25   GLU G CB  1 
ATOM   76   C CG  . GLU A 1 10  ? -31.752 44.824  -97.004  1.00 59.84  ? 25   GLU G CG  1 
ATOM   77   C CD  . GLU A 1 10  ? -30.995 46.137  -97.094  1.00 72.43  ? 25   GLU G CD  1 
ATOM   78   O OE1 . GLU A 1 10  ? -31.548 47.110  -97.649  1.00 82.83  ? 25   GLU G OE1 1 
ATOM   79   O OE2 . GLU A 1 10  ? -29.844 46.198  -96.612  1.00 60.63  ? 25   GLU G OE2 1 
ATOM   80   N N   . GLU A 1 11  ? -32.992 42.243  -100.685 1.00 51.98  ? 26   GLU G N   1 
ATOM   81   C CA  . GLU A 1 11  ? -33.625 42.037  -101.985 1.00 36.29  ? 26   GLU G CA  1 
ATOM   82   C C   . GLU A 1 11  ? -34.828 41.111  -101.861 1.00 34.17  ? 26   GLU G C   1 
ATOM   83   O O   . GLU A 1 11  ? -35.895 41.380  -102.424 1.00 43.13  ? 26   GLU G O   1 
ATOM   84   C CB  . GLU A 1 11  ? -32.617 41.463  -102.984 1.00 36.42  ? 26   GLU G CB  1 
ATOM   85   C CG  . GLU A 1 11  ? -31.764 42.496  -103.711 1.00 53.01  ? 26   GLU G CG  1 
ATOM   86   C CD  . GLU A 1 11  ? -30.745 41.858  -104.647 1.00 62.94  ? 26   GLU G CD  1 
ATOM   87   O OE1 . GLU A 1 11  ? -30.911 40.667  -104.993 1.00 50.32  ? 26   GLU G OE1 1 
ATOM   88   O OE2 . GLU A 1 11  ? -29.778 42.549  -105.036 1.00 73.92  ? 26   GLU G OE2 1 
ATOM   89   N N   . HIS A 1 12  ? -34.666 40.009  -101.124 1.00 46.08  ? 27   HIS G N   1 
ATOM   90   C CA  . HIS A 1 12  ? -35.751 39.046  -100.962 1.00 53.08  ? 27   HIS G CA  1 
ATOM   91   C C   . HIS A 1 12  ? -36.955 39.679  -100.270 1.00 56.17  ? 27   HIS G C   1 
ATOM   92   O O   . HIS A 1 12  ? -38.099 39.482  -100.698 1.00 57.11  ? 27   HIS G O   1 
ATOM   93   C CB  . HIS A 1 12  ? -35.244 37.833  -100.181 1.00 49.43  ? 27   HIS G CB  1 
ATOM   94   C CG  . HIS A 1 12  ? -36.317 36.864  -99.785  1.00 67.50  ? 27   HIS G CG  1 
ATOM   95   N ND1 . HIS A 1 12  ? -37.546 36.810  -100.407 1.00 73.54  ? 27   HIS G ND1 1 
ATOM   96   C CD2 . HIS A 1 12  ? -36.347 35.922  -98.813  1.00 85.94  ? 27   HIS G CD2 1 
ATOM   97   C CE1 . HIS A 1 12  ? -38.284 35.872  -99.840  1.00 91.30  ? 27   HIS G CE1 1 
ATOM   98   N NE2 . HIS A 1 12  ? -37.580 35.318  -98.870  1.00 105.22 ? 27   HIS G NE2 1 
ATOM   99   N N   . LEU A 1 13  ? -36.718 40.443  -99.202  1.00 51.03  ? 28   LEU G N   1 
ATOM   100  C CA  . LEU A 1 13  ? -37.829 41.027  -98.456  1.00 33.67  ? 28   LEU G CA  1 
ATOM   101  C C   . LEU A 1 13  ? -38.593 42.040  -99.300  1.00 43.90  ? 28   LEU G C   1 
ATOM   102  O O   . LEU A 1 13  ? -39.829 42.047  -99.304  1.00 59.52  ? 28   LEU G O   1 
ATOM   103  C CB  . LEU A 1 13  ? -37.314 41.675  -97.173  1.00 27.47  ? 28   LEU G CB  1 
ATOM   104  C CG  . LEU A 1 13  ? -36.966 40.681  -96.066  1.00 38.44  ? 28   LEU G CG  1 
ATOM   105  C CD1 . LEU A 1 13  ? -36.388 41.392  -94.854  1.00 39.60  ? 28   LEU G CD1 1 
ATOM   106  C CD2 . LEU A 1 13  ? -38.188 39.861  -95.682  1.00 45.72  ? 28   LEU G CD2 1 
ATOM   107  N N   . ALA A 1 14  ? -37.873 42.896  -100.031 1.00 36.62  ? 29   ALA G N   1 
ATOM   108  C CA  . ALA A 1 14  ? -38.533 43.902  -100.857 1.00 37.71  ? 29   ALA G CA  1 
ATOM   109  C C   . ALA A 1 14  ? -39.405 43.266  -101.932 1.00 39.16  ? 29   ALA G C   1 
ATOM   110  O O   . ALA A 1 14  ? -40.384 43.875  -102.379 1.00 38.54  ? 29   ALA G O   1 
ATOM   111  C CB  . ALA A 1 14  ? -37.490 44.821  -101.493 1.00 49.21  ? 29   ALA G CB  1 
ATOM   112  N N   . LEU A 1 15  ? -39.072 42.050  -102.352 1.00 43.57  ? 30   LEU G N   1 
ATOM   113  C CA  . LEU A 1 15  ? -39.852 41.336  -103.355 1.00 47.00  ? 30   LEU G CA  1 
ATOM   114  C C   . LEU A 1 15  ? -41.109 40.720  -102.747 1.00 68.68  ? 30   LEU G C   1 
ATOM   115  O O   . LEU A 1 15  ? -42.166 40.697  -103.378 1.00 84.51  ? 30   LEU G O   1 
ATOM   116  C CB  . LEU A 1 15  ? -39.006 40.246  -104.012 1.00 50.08  ? 30   LEU G CB  1 
ATOM   117  C CG  . LEU A 1 15  ? -39.322 39.939  -105.476 1.00 54.07  ? 30   LEU G CG  1 
ATOM   118  C CD1 . LEU A 1 15  ? -38.641 40.952  -106.381 1.00 50.72  ? 30   LEU G CD1 1 
ATOM   119  C CD2 . LEU A 1 15  ? -38.897 38.521  -105.829 1.00 53.67  ? 30   LEU G CD2 1 
HETATM 120  N N   . NLE A 1 16  ? -40.984 40.219  -101.521 1.00 59.49  ? 31   NLE G N   1 
HETATM 121  C CA  . NLE A 1 16  ? -42.094 39.560  -100.842 1.00 47.15  ? 31   NLE G CA  1 
HETATM 122  C C   . NLE A 1 16  ? -43.243 40.521  -100.555 1.00 51.72  ? 31   NLE G C   1 
HETATM 123  O O   . NLE A 1 16  ? -44.407 40.190  -100.792 1.00 59.00  ? 31   NLE G O   1 
HETATM 124  C CB  . NLE A 1 16  ? -41.617 38.917  -99.537  1.00 53.10  ? 31   NLE G CB  1 
HETATM 125  C CG  . NLE A 1 16  ? -42.727 38.254  -98.734  1.00 58.44  ? 31   NLE G CG  1 
HETATM 126  C CD  . NLE A 1 16  ? -42.189 37.593  -97.473  1.00 53.80  ? 31   NLE G CD  1 
HETATM 127  C CE  . NLE A 1 16  ? -41.552 38.611  -96.540  1.00 44.59  ? 31   NLE G CE  1 
ATOM   128  N N   . VAL A 1 17  ? -42.912 41.709  -100.053 1.00 50.06  ? 32   VAL G N   1 
ATOM   129  C CA  . VAL A 1 17  ? -43.924 42.694  -99.678  1.00 61.20  ? 32   VAL G CA  1 
ATOM   130  C C   . VAL A 1 17  ? -44.753 43.142  -100.881 1.00 69.49  ? 32   VAL G C   1 
ATOM   131  O O   . VAL A 1 17  ? -45.884 43.605  -100.725 1.00 65.96  ? 32   VAL G O   1 
ATOM   132  C CB  . VAL A 1 17  ? -43.279 43.910  -98.973  1.00 58.60  ? 32   VAL G CB  1 
ATOM   133  C CG1 . VAL A 1 17  ? -42.256 43.447  -97.951  1.00 34.38  ? 32   VAL G CG1 1 
ATOM   134  C CG2 . VAL A 1 17  ? -42.641 44.859  -99.988  1.00 45.54  ? 32   VAL G CG2 1 
ATOM   135  N N   . GLU A 1 18  ? -44.196 42.984  -102.079 1.00 63.87  ? 33   GLU G N   1 
ATOM   136  C CA  . GLU A 1 18  ? -44.885 43.378  -103.300 1.00 60.54  ? 33   GLU G CA  1 
ATOM   137  C C   . GLU A 1 18  ? -45.536 42.175  -103.976 1.00 63.00  ? 33   GLU G C   1 
ATOM   138  O O   . GLU A 1 18  ? -46.757 42.125  -104.135 1.00 85.85  ? 33   GLU G O   1 
ATOM   139  C CB  . GLU A 1 18  ? -43.915 44.067  -104.262 1.00 67.34  ? 33   GLU G CB  1 
ATOM   140  C CG  . GLU A 1 18  ? -43.208 45.277  -103.664 1.00 93.18  ? 33   GLU G CG  1 
ATOM   141  C CD  . GLU A 1 18  ? -43.717 46.592  -104.229 1.00 105.49 ? 33   GLU G CD  1 
ATOM   142  O OE1 . GLU A 1 18  ? -44.191 46.599  -105.387 1.00 87.08  ? 33   GLU G OE1 1 
ATOM   143  O OE2 . GLU A 1 18  ? -43.644 47.617  -103.515 1.00 82.56  ? 33   GLU G OE2 1 
HETATM 144  C C   . ACE B 1 1   ? -81.694 12.866  -50.243  1.00 66.72  ? 16   ACE F C   1 
HETATM 145  O O   . ACE B 1 1   ? -81.032 11.995  -50.807  1.00 49.99  ? 16   ACE F O   1 
HETATM 146  C CH3 . ACE B 1 1   ? -83.194 12.862  -50.183  1.00 78.37  ? 16   ACE F CH3 1 
ATOM   147  N N   . LEU B 1 2   ? -81.132 13.898  -49.637  1.00 69.54  ? 17   LEU F N   1 
ATOM   148  C CA  . LEU B 1 2   ? -79.693 14.091  -49.580  1.00 55.10  ? 17   LEU F CA  1 
ATOM   149  C C   . LEU B 1 2   ? -79.110 13.315  -48.404  1.00 60.30  ? 17   LEU F C   1 
ATOM   150  O O   . LEU B 1 2   ? -77.945 12.906  -48.418  1.00 59.53  ? 17   LEU F O   1 
ATOM   151  C CB  . LEU B 1 2   ? -79.370 15.582  -49.459  1.00 52.37  ? 17   LEU F CB  1 
ATOM   152  C CG  . LEU B 1 2   ? -77.895 15.927  -49.593  1.00 36.82  ? 17   LEU F CG  1 
ATOM   153  C CD1 . LEU B 1 2   ? -77.357 15.086  -50.711  1.00 45.48  ? 17   LEU F CD1 1 
ATOM   154  C CD2 . LEU B 1 2   ? -77.703 17.411  -49.897  1.00 46.08  ? 17   LEU F CD2 1 
ATOM   155  N N   . ASP B 1 3   ? -79.955 13.113  -47.400  1.00 66.19  ? 18   ASP F N   1 
ATOM   156  C CA  . ASP B 1 3   ? -79.563 12.550  -46.114  1.00 74.38  ? 18   ASP F CA  1 
ATOM   157  C C   . ASP B 1 3   ? -78.802 11.238  -46.237  1.00 61.20  ? 18   ASP F C   1 
ATOM   158  O O   . ASP B 1 3   ? -77.663 11.137  -45.773  1.00 59.23  ? 18   ASP F O   1 
ATOM   159  C CB  . ASP B 1 3   ? -80.803 12.347  -45.246  1.00 89.33  ? 18   ASP F CB  1 
ATOM   160  C CG  . ASP B 1 3   ? -81.732 13.544  -45.282  1.00 106.38 ? 18   ASP F CG  1 
ATOM   161  O OD1 . ASP B 1 3   ? -81.229 14.688  -45.315  1.00 102.06 ? 18   ASP F OD1 1 
ATOM   162  O OD2 . ASP B 1 3   ? -82.965 13.339  -45.287  1.00 114.02 ? 18   ASP F OD2 1 
HETATM 163  C C   . MK8 B 1 4   ? -77.441 9.158   -47.761  1.00 53.48  ? 19   MK8 F C   1 
HETATM 164  N N   . MK8 B 1 4   ? -79.444 10.245  -46.853  1.00 46.34  ? 19   MK8 F N   1 
HETATM 165  O O   . MK8 B 1 4   ? -76.429 8.762   -47.147  1.00 60.27  ? 19   MK8 F O   1 
HETATM 166  C CA  . MK8 B 1 4   ? -78.819 8.919   -47.106  1.00 44.28  ? 19   MK8 F CA  1 
HETATM 167  C CB  . MK8 B 1 4   ? -79.724 8.025   -47.984  1.00 39.44  ? 19   MK8 F CB  1 
HETATM 168  C CD  . MK8 B 1 4   ? -78.392 6.557   -49.613  1.00 53.57  ? 19   MK8 F CD  1 
HETATM 169  C CE  . MK8 B 1 4   ? -77.761 5.205   -49.876  1.00 29.94  ? 19   MK8 F CE  1 
HETATM 170  C CG  . MK8 B 1 4   ? -79.217 6.634   -48.350  1.00 38.71  ? 19   MK8 F CG  1 
HETATM 171  C CB1 . MK8 B 1 4   ? -78.625 8.212   -45.764  1.00 49.25  ? 19   MK8 F CB1 1 
ATOM   172  N N   . ASN B 1 5   ? -77.412 9.808   -48.919  1.00 50.41  ? 20   ASN F N   1 
ATOM   173  C CA  . ASN B 1 5   ? -76.174 10.015  -49.660  1.00 47.98  ? 20   ASN F CA  1 
ATOM   174  C C   . ASN B 1 5   ? -75.120 10.753  -48.849  1.00 43.78  ? 20   ASN F C   1 
ATOM   175  O O   . ASN B 1 5   ? -73.936 10.441  -48.940  1.00 56.87  ? 20   ASN F O   1 
ATOM   176  C CB  . ASN B 1 5   ? -76.473 10.751  -50.955  1.00 49.99  ? 20   ASN F CB  1 
ATOM   177  C CG  . ASN B 1 5   ? -77.460 10.002  -51.815  1.00 55.43  ? 20   ASN F CG  1 
ATOM   178  O OD1 . ASN B 1 5   ? -78.651 10.313  -51.827  1.00 66.38  ? 20   ASN F OD1 1 
ATOM   179  N ND2 . ASN B 1 5   ? -76.973 8.995   -52.534  1.00 49.29  ? 20   ASN F ND2 1 
ATOM   180  N N   . PHE B 1 6   ? -75.559 11.724  -48.047  1.00 37.68  ? 21   PHE F N   1 
ATOM   181  C CA  . PHE B 1 6   ? -74.637 12.419  -47.156  1.00 37.92  ? 21   PHE F CA  1 
ATOM   182  C C   . PHE B 1 6   ? -74.009 11.447  -46.164  1.00 46.40  ? 21   PHE F C   1 
ATOM   183  O O   . PHE B 1 6   ? -72.791 11.453  -45.953  1.00 48.19  ? 21   PHE F O   1 
ATOM   184  C CB  . PHE B 1 6   ? -75.374 13.548  -46.431  1.00 46.34  ? 21   PHE F CB  1 
ATOM   185  C CG  . PHE B 1 6   ? -74.475 14.489  -45.671  1.00 39.11  ? 21   PHE F CG  1 
ATOM   186  C CD1 . PHE B 1 6   ? -73.858 14.096  -44.494  1.00 52.85  ? 21   PHE F CD1 1 
ATOM   187  C CD2 . PHE B 1 6   ? -74.257 15.776  -46.133  1.00 49.79  ? 21   PHE F CD2 1 
ATOM   188  C CE1 . PHE B 1 6   ? -73.039 14.965  -43.798  1.00 50.96  ? 21   PHE F CE1 1 
ATOM   189  C CE2 . PHE B 1 6   ? -73.437 16.648  -45.441  1.00 47.97  ? 21   PHE F CE2 1 
ATOM   190  C CZ  . PHE B 1 6   ? -72.827 16.240  -44.272  1.00 42.05  ? 21   PHE F CZ  1 
ATOM   191  N N   . LYS B 1 7   ? -74.828 10.599  -45.552  1.00 49.75  ? 22   LYS F N   1 
ATOM   192  C CA  . LYS B 1 7   ? -74.354 9.697   -44.510  1.00 42.27  ? 22   LYS F CA  1 
ATOM   193  C C   . LYS B 1 7   ? -73.383 8.660   -45.059  1.00 42.40  ? 22   LYS F C   1 
ATOM   194  O O   . LYS B 1 7   ? -72.261 8.547   -44.565  1.00 53.57  ? 22   LYS F O   1 
ATOM   195  C CB  . LYS B 1 7   ? -75.536 9.011   -43.826  1.00 45.54  ? 22   LYS F CB  1 
ATOM   196  C CG  . LYS B 1 7   ? -75.910 9.639   -42.490  1.00 78.12  ? 22   LYS F CG  1 
ATOM   197  C CD  . LYS B 1 7   ? -76.695 10.934  -42.675  1.00 75.29  ? 22   LYS F CD  1 
ATOM   198  C CE  . LYS B 1 7   ? -76.839 11.695  -41.361  1.00 58.03  ? 22   LYS F CE  1 
ATOM   199  N NZ  . LYS B 1 7   ? -75.528 11.933  -40.690  1.00 47.03  ? 22   LYS F NZ  1 
HETATM 200  C C   . MK8 B 1 8   ? -71.665 7.481   -47.192  1.00 43.72  ? 23   MK8 F C   1 
HETATM 201  N N   . MK8 B 1 8   ? -73.817 7.926   -46.084  1.00 39.08  ? 23   MK8 F N   1 
HETATM 202  O O   . MK8 B 1 8   ? -70.629 6.793   -47.095  1.00 58.62  ? 23   MK8 F O   1 
HETATM 203  C CA  . MK8 B 1 8   ? -72.990 6.853   -46.703  1.00 34.49  ? 23   MK8 F CA  1 
HETATM 204  C CB  . MK8 B 1 8   ? -73.747 6.123   -47.835  1.00 30.33  ? 23   MK8 F CB  1 
HETATM 205  C CD  . MK8 B 1 8   ? -75.716 6.691   -49.326  1.00 62.94  ? 23   MK8 F CD  1 
HETATM 206  C CE  . MK8 B 1 8   ? -76.156 5.326   -49.791  1.00 48.38  ? 23   MK8 F CE  1 
HETATM 207  C CG  . MK8 B 1 8   ? -74.267 6.949   -49.001  1.00 57.38  ? 23   MK8 F CG  1 
HETATM 208  C CB1 . MK8 B 1 8   ? -72.703 5.791   -45.642  1.00 60.00  ? 23   MK8 F CB1 1 
HETATM 209  N N   . NLE B 1 9   ? -71.689 8.728   -47.658  1.00 45.39  ? 24   NLE F N   1 
HETATM 210  C CA  . NLE B 1 9   ? -70.474 9.403   -48.115  1.00 30.87  ? 24   NLE F CA  1 
HETATM 211  C C   . NLE B 1 9   ? -69.525 9.664   -46.950  1.00 37.38  ? 24   NLE F C   1 
HETATM 212  O O   . NLE B 1 9   ? -68.303 9.643   -47.110  1.00 40.85  ? 24   NLE F O   1 
HETATM 213  C CB  . NLE B 1 9   ? -70.820 10.717  -48.818  1.00 22.25  ? 24   NLE F CB  1 
HETATM 214  C CG  . NLE B 1 9   ? -70.062 10.949  -50.116  1.00 50.87  ? 24   NLE F CG  1 
HETATM 215  C CD  . NLE B 1 9   ? -68.918 11.929  -49.917  1.00 55.81  ? 24   NLE F CD  1 
HETATM 216  C CE  . NLE B 1 9   ? -67.643 11.438  -50.584  1.00 38.49  ? 24   NLE F CE  1 
ATOM   217  N N   . GLU B 1 10  ? -70.099 9.903   -45.776  1.00 32.83  ? 25   GLU F N   1 
ATOM   218  C CA  . GLU B 1 10  ? -69.313 10.167  -44.578  1.00 31.56  ? 25   GLU F CA  1 
ATOM   219  C C   . GLU B 1 10  ? -68.610 8.899   -44.113  1.00 37.27  ? 25   GLU F C   1 
ATOM   220  O O   . GLU B 1 10  ? -67.418 8.924   -43.806  1.00 47.42  ? 25   GLU F O   1 
ATOM   221  C CB  . GLU B 1 10  ? -70.199 10.725  -43.464  1.00 31.83  ? 25   GLU F CB  1 
ATOM   222  C CG  . GLU B 1 10  ? -70.556 12.188  -43.642  1.00 27.41  ? 25   GLU F CG  1 
ATOM   223  C CD  . GLU B 1 10  ? -70.991 12.850  -42.349  1.00 47.77  ? 25   GLU F CD  1 
ATOM   224  O OE1 . GLU B 1 10  ? -71.948 12.354  -41.713  1.00 49.24  ? 25   GLU F OE1 1 
ATOM   225  O OE2 . GLU B 1 10  ? -70.374 13.869  -41.969  1.00 49.83  ? 25   GLU F OE2 1 
ATOM   226  N N   . GLU B 1 11  ? -69.362 7.796   -44.053  1.00 38.71  ? 26   GLU F N   1 
ATOM   227  C CA  . GLU B 1 11  ? -68.765 6.500   -43.743  1.00 32.87  ? 26   GLU F CA  1 
ATOM   228  C C   . GLU B 1 11  ? -67.616 6.201   -44.693  1.00 35.19  ? 26   GLU F C   1 
ATOM   229  O O   . GLU B 1 11  ? -66.542 5.755   -44.275  1.00 48.76  ? 26   GLU F O   1 
ATOM   230  C CB  . GLU B 1 11  ? -69.817 5.395   -43.839  1.00 40.00  ? 26   GLU F CB  1 
ATOM   231  C CG  . GLU B 1 11  ? -70.623 5.125   -42.581  1.00 52.52  ? 26   GLU F CG  1 
ATOM   232  C CD  . GLU B 1 11  ? -71.657 4.022   -42.787  1.00 61.09  ? 26   GLU F CD  1 
ATOM   233  O OE1 . GLU B 1 11  ? -71.557 3.288   -43.797  1.00 39.84  ? 26   GLU F OE1 1 
ATOM   234  O OE2 . GLU B 1 11  ? -72.572 3.893   -41.945  1.00 61.70  ? 26   GLU F OE2 1 
ATOM   235  N N   . HIS B 1 12  ? -67.833 6.446   -45.986  1.00 36.02  ? 27   HIS F N   1 
ATOM   236  C CA  . HIS B 1 12  ? -66.814 6.146   -46.983  1.00 37.14  ? 27   HIS F CA  1 
ATOM   237  C C   . HIS B 1 12  ? -65.552 6.960   -46.735  1.00 35.99  ? 27   HIS F C   1 
ATOM   238  O O   . HIS B 1 12  ? -64.437 6.426   -46.769  1.00 48.82  ? 27   HIS F O   1 
ATOM   239  C CB  . HIS B 1 12  ? -67.360 6.414   -48.384  1.00 26.99  ? 27   HIS F CB  1 
ATOM   240  C CG  . HIS B 1 12  ? -66.330 6.289   -49.459  1.00 44.27  ? 27   HIS F CG  1 
ATOM   241  N ND1 . HIS B 1 12  ? -65.345 5.325   -49.435  1.00 49.41  ? 27   HIS F ND1 1 
ATOM   242  C CD2 . HIS B 1 12  ? -66.128 7.006   -50.590  1.00 46.33  ? 27   HIS F CD2 1 
ATOM   243  C CE1 . HIS B 1 12  ? -64.579 5.456   -50.503  1.00 52.76  ? 27   HIS F CE1 1 
ATOM   244  N NE2 . HIS B 1 12  ? -65.033 6.468   -51.220  1.00 56.22  ? 27   HIS F NE2 1 
ATOM   245  N N   . LEU B 1 13  ? -65.709 8.259   -46.476  1.00 24.76  ? 28   LEU F N   1 
ATOM   246  C CA  . LEU B 1 13  ? -64.546 9.090   -46.195  1.00 34.72  ? 28   LEU F CA  1 
ATOM   247  C C   . LEU B 1 13  ? -63.842 8.649   -44.919  1.00 38.21  ? 28   LEU F C   1 
ATOM   248  O O   . LEU B 1 13  ? -62.619 8.798   -44.800  1.00 40.83  ? 28   LEU F O   1 
ATOM   249  C CB  . LEU B 1 13  ? -64.963 10.557  -46.105  1.00 32.87  ? 28   LEU F CB  1 
ATOM   250  C CG  . LEU B 1 13  ? -65.365 11.194  -47.439  1.00 26.47  ? 28   LEU F CG  1 
ATOM   251  C CD1 . LEU B 1 13  ? -66.358 12.320  -47.222  1.00 24.47  ? 28   LEU F CD1 1 
ATOM   252  C CD2 . LEU B 1 13  ? -64.143 11.699  -48.188  1.00 32.53  ? 28   LEU F CD2 1 
ATOM   253  N N   . ALA B 1 14  ? -64.589 8.088   -43.964  1.00 37.26  ? 29   ALA F N   1 
ATOM   254  C CA  . ALA B 1 14  ? -63.979 7.630   -42.721  1.00 24.88  ? 29   ALA F CA  1 
ATOM   255  C C   . ALA B 1 14  ? -62.967 6.515   -42.969  1.00 37.12  ? 29   ALA F C   1 
ATOM   256  O O   . ALA B 1 14  ? -61.897 6.499   -42.352  1.00 51.41  ? 29   ALA F O   1 
ATOM   257  C CB  . ALA B 1 14  ? -65.059 7.173   -41.741  1.00 23.48  ? 29   ALA F CB  1 
ATOM   258  N N   . LEU B 1 15  ? -63.281 5.577   -43.862  1.00 32.96  ? 30   LEU F N   1 
ATOM   259  C CA  . LEU B 1 15  ? -62.340 4.501   -44.186  1.00 34.91  ? 30   LEU F CA  1 
ATOM   260  C C   . LEU B 1 15  ? -61.147 5.027   -44.946  1.00 40.97  ? 30   LEU F C   1 
ATOM   261  O O   . LEU B 1 15  ? -60.017 4.602   -44.714  1.00 50.45  ? 30   LEU F O   1 
ATOM   262  C CB  . LEU B 1 15  ? -63.000 3.406   -45.024  1.00 34.43  ? 30   LEU F CB  1 
ATOM   263  C CG  . LEU B 1 15  ? -63.534 2.183   -44.288  1.00 35.48  ? 30   LEU F CG  1 
ATOM   264  C CD1 . LEU B 1 15  ? -62.453 1.560   -43.407  1.00 48.53  ? 30   LEU F CD1 1 
ATOM   265  C CD2 . LEU B 1 15  ? -64.750 2.581   -43.482  1.00 35.21  ? 30   LEU F CD2 1 
HETATM 266  N N   . NLE B 1 16  ? -61.417 5.939   -45.874  1.00 30.98  ? 31   NLE F N   1 
HETATM 267  C CA  . NLE B 1 16  ? -60.418 6.379   -46.834  1.00 35.54  ? 31   NLE F CA  1 
HETATM 268  C C   . NLE B 1 16  ? -59.175 6.952   -46.164  1.00 43.59  ? 31   NLE F C   1 
HETATM 269  O O   . NLE B 1 16  ? -58.055 6.531   -46.456  1.00 51.33  ? 31   NLE F O   1 
HETATM 270  C CB  . NLE B 1 16  ? -61.018 7.417   -47.778  1.00 30.03  ? 31   NLE F CB  1 
HETATM 271  C CG  . NLE B 1 16  ? -60.196 7.647   -49.028  1.00 43.39  ? 31   NLE F CG  1 
HETATM 272  C CD  . NLE B 1 16  ? -60.444 9.032   -49.592  1.00 43.51  ? 31   NLE F CD  1 
HETATM 273  C CE  . NLE B 1 16  ? -61.929 9.290   -49.779  1.00 36.27  ? 31   NLE F CE  1 
ATOM   274  N N   . VAL B 1 17  ? -59.378 7.897   -45.255  1.00 31.00  ? 32   VAL F N   1 
ATOM   275  C CA  . VAL B 1 17  ? -58.271 8.605   -44.626  1.00 31.86  ? 32   VAL F CA  1 
ATOM   276  C C   . VAL B 1 17  ? -57.401 7.690   -43.755  1.00 51.95  ? 32   VAL F C   1 
ATOM   277  O O   . VAL B 1 17  ? -56.245 8.014   -43.470  1.00 47.64  ? 32   VAL F O   1 
ATOM   278  C CB  . VAL B 1 17  ? -58.799 9.800   -43.809  1.00 31.39  ? 32   VAL F CB  1 
ATOM   279  C CG1 . VAL B 1 17  ? -59.845 10.553  -44.609  1.00 22.86  ? 32   VAL F CG1 1 
ATOM   280  C CG2 . VAL B 1 17  ? -59.392 9.327   -42.495  1.00 34.85  ? 32   VAL F CG2 1 
ATOM   281  N N   . GLU B 1 18  ? -57.945 6.546   -43.347  1.00 54.47  ? 33   GLU F N   1 
ATOM   282  C CA  . GLU B 1 18  ? -57.199 5.610   -42.512  1.00 43.30  ? 33   GLU F CA  1 
ATOM   283  C C   . GLU B 1 18  ? -56.661 4.444   -43.335  1.00 33.83  ? 33   GLU F C   1 
ATOM   284  O O   . GLU B 1 18  ? -56.048 3.523   -42.792  1.00 41.41  ? 33   GLU F O   1 
ATOM   285  C CB  . GLU B 1 18  ? -58.073 5.086   -41.369  1.00 49.14  ? 33   GLU F CB  1 
ATOM   286  C CG  . GLU B 1 18  ? -59.111 6.078   -40.863  1.00 63.88  ? 33   GLU F CG  1 
ATOM   287  C CD  . GLU B 1 18  ? -58.557 7.029   -39.812  1.00 79.84  ? 33   GLU F CD  1 
ATOM   288  O OE1 . GLU B 1 18  ? -59.301 7.941   -39.382  1.00 68.26  ? 33   GLU F OE1 1 
ATOM   289  O OE2 . GLU B 1 18  ? -57.382 6.868   -39.417  1.00 73.69  ? 33   GLU F OE2 1 
ATOM   290  N N   . GLY C 2 1   ? -78.092 -14.746 -68.929  1.00 77.69  ? 13   GLY B N   1 
ATOM   291  C CA  . GLY C 2 1   ? -79.526 -14.527 -68.985  1.00 90.26  ? 13   GLY B CA  1 
ATOM   292  C C   . GLY C 2 1   ? -79.952 -13.190 -68.407  1.00 98.91  ? 13   GLY B C   1 
ATOM   293  O O   . GLY C 2 1   ? -79.862 -12.167 -69.088  1.00 105.53 ? 13   GLY B O   1 
ATOM   294  N N   . PRO C 2 2   ? -80.439 -13.202 -67.163  1.00 98.79  ? 14   PRO B N   1 
ATOM   295  C CA  . PRO C 2 2   ? -80.759 -11.935 -66.482  1.00 102.21 ? 14   PRO B CA  1 
ATOM   296  C C   . PRO C 2 2   ? -79.630 -10.919 -66.512  1.00 90.40  ? 14   PRO B C   1 
ATOM   297  O O   . PRO C 2 2   ? -79.895 -9.710  -66.463  1.00 82.17  ? 14   PRO B O   1 
ATOM   298  C CB  . PRO C 2 2   ? -81.066 -12.376 -65.042  1.00 88.28  ? 14   PRO B CB  1 
ATOM   299  C CG  . PRO C 2 2   ? -81.273 -13.870 -65.091  1.00 89.35  ? 14   PRO B CG  1 
ATOM   300  C CD  . PRO C 2 2   ? -81.041 -14.363 -66.489  1.00 94.77  ? 14   PRO B CD  1 
ATOM   301  N N   . HIS C 2 3   ? -78.374 -11.371 -66.581  1.00 85.32  ? 15   HIS B N   1 
ATOM   302  C CA  . HIS C 2 3   ? -77.257 -10.437 -66.664  1.00 85.05  ? 15   HIS B CA  1 
ATOM   303  C C   . HIS C 2 3   ? -77.246 -9.694  -67.992  1.00 87.88  ? 15   HIS B C   1 
ATOM   304  O O   . HIS C 2 3   ? -76.831 -8.530  -68.045  1.00 90.25  ? 15   HIS B O   1 
ATOM   305  C CB  . HIS C 2 3   ? -75.933 -11.176 -66.463  1.00 77.86  ? 15   HIS B CB  1 
ATOM   306  C CG  . HIS C 2 3   ? -74.733 -10.279 -66.478  1.00 89.92  ? 15   HIS B CG  1 
ATOM   307  N ND1 . HIS C 2 3   ? -73.516 -10.672 -66.992  1.00 92.38  ? 15   HIS B ND1 1 
ATOM   308  C CD2 . HIS C 2 3   ? -74.563 -9.009  -66.039  1.00 93.90  ? 15   HIS B CD2 1 
ATOM   309  C CE1 . HIS C 2 3   ? -72.649 -9.682  -66.871  1.00 95.43  ? 15   HIS B CE1 1 
ATOM   310  N NE2 . HIS C 2 3   ? -73.259 -8.662  -66.296  1.00 101.01 ? 15   HIS B NE2 1 
ATOM   311  N N   . MET C 2 4   ? -77.694 -10.343 -69.070  1.00 83.06  ? 16   MET B N   1 
ATOM   312  C CA  . MET C 2 4   ? -77.695 -9.685  -70.372  1.00 88.28  ? 16   MET B CA  1 
ATOM   313  C C   . MET C 2 4   ? -78.699 -8.540  -70.412  1.00 86.45  ? 16   MET B C   1 
ATOM   314  O O   . MET C 2 4   ? -78.432 -7.499  -71.025  1.00 95.99  ? 16   MET B O   1 
ATOM   315  C CB  . MET C 2 4   ? -77.983 -10.698 -71.479  1.00 93.08  ? 16   MET B CB  1 
ATOM   316  C CG  . MET C 2 4   ? -77.408 -10.309 -72.836  1.00 112.04 ? 16   MET B CG  1 
ATOM   317  S SD  . MET C 2 4   ? -75.806 -9.482  -72.708  1.00 130.03 ? 16   MET B SD  1 
ATOM   318  C CE  . MET C 2 4   ? -76.132 -7.938  -73.558  1.00 68.07  ? 16   MET B CE  1 
ATOM   319  N N   . LEU C 2 5   ? -79.861 -8.707  -69.771  1.00 62.78  ? 17   LEU B N   1 
ATOM   320  C CA  . LEU C 2 5   ? -80.794 -7.588  -69.675  1.00 67.08  ? 17   LEU B CA  1 
ATOM   321  C C   . LEU C 2 5   ? -80.196 -6.477  -68.822  1.00 76.35  ? 17   LEU B C   1 
ATOM   322  O O   . LEU C 2 5   ? -80.369 -5.290  -69.121  1.00 73.02  ? 17   LEU B O   1 
ATOM   323  C CB  . LEU C 2 5   ? -82.135 -8.056  -69.094  1.00 79.75  ? 17   LEU B CB  1 
ATOM   324  C CG  . LEU C 2 5   ? -83.281 -7.098  -68.711  1.00 94.04  ? 17   LEU B CG  1 
ATOM   325  C CD1 . LEU C 2 5   ? -83.439 -5.898  -69.661  1.00 71.79  ? 17   LEU B CD1 1 
ATOM   326  C CD2 . LEU C 2 5   ? -84.596 -7.868  -68.572  1.00 78.17  ? 17   LEU B CD2 1 
ATOM   327  N N   . GLU C 2 6   ? -79.465 -6.846  -67.765  1.00 71.51  ? 18   GLU B N   1 
ATOM   328  C CA  . GLU C 2 6   ? -78.826 -5.836  -66.930  1.00 66.11  ? 18   GLU B CA  1 
ATOM   329  C C   . GLU C 2 6   ? -77.739 -5.093  -67.696  1.00 74.49  ? 18   GLU B C   1 
ATOM   330  O O   . GLU C 2 6   ? -77.631 -3.866  -67.591  1.00 83.10  ? 18   GLU B O   1 
ATOM   331  C CB  . GLU C 2 6   ? -78.254 -6.471  -65.662  1.00 62.00  ? 18   GLU B CB  1 
ATOM   332  C CG  . GLU C 2 6   ? -77.769 -5.454  -64.633  1.00 70.92  ? 18   GLU B CG  1 
ATOM   333  C CD  . GLU C 2 6   ? -78.907 -4.778  -63.876  1.00 83.80  ? 18   GLU B CD  1 
ATOM   334  O OE1 . GLU C 2 6   ? -80.087 -4.951  -64.256  1.00 83.99  ? 18   GLU B OE1 1 
ATOM   335  O OE2 . GLU C 2 6   ? -78.616 -4.071  -62.889  1.00 81.69  ? 18   GLU B OE2 1 
ATOM   336  N N   . ARG C 2 7   ? -76.932 -5.815  -68.478  1.00 63.82  ? 19   ARG B N   1 
ATOM   337  C CA  . ARG C 2 7   ? -75.909 -5.159  -69.285  1.00 54.16  ? 19   ARG B CA  1 
ATOM   338  C C   . ARG C 2 7   ? -76.530 -4.183  -70.276  1.00 53.19  ? 19   ARG B C   1 
ATOM   339  O O   . ARG C 2 7   ? -76.015 -3.077  -70.477  1.00 62.04  ? 19   ARG B O   1 
ATOM   340  C CB  . ARG C 2 7   ? -75.067 -6.202  -70.019  1.00 65.17  ? 19   ARG B CB  1 
ATOM   341  C CG  . ARG C 2 7   ? -73.939 -6.785  -69.187  1.00 73.95  ? 19   ARG B CG  1 
ATOM   342  C CD  . ARG C 2 7   ? -72.939 -5.713  -68.791  1.00 59.76  ? 19   ARG B CD  1 
ATOM   343  N NE  . ARG C 2 7   ? -71.803 -5.672  -69.704  1.00 58.74  ? 19   ARG B NE  1 
ATOM   344  C CZ  . ARG C 2 7   ? -70.623 -5.147  -69.407  1.00 60.91  ? 19   ARG B CZ  1 
ATOM   345  N NH1 . ARG C 2 7   ? -70.384 -4.611  -68.221  1.00 41.96  ? 19   ARG B NH1 1 
ATOM   346  N NH2 . ARG C 2 7   ? -69.657 -5.162  -70.321  1.00 66.11  ? 19   ARG B NH2 1 
ATOM   347  N N   . GLU C 2 8   ? -77.644 -4.572  -70.900  1.00 66.91  ? 20   GLU B N   1 
ATOM   348  C CA  . GLU C 2 8   ? -78.306 -3.687  -71.852  1.00 71.01  ? 20   GLU B CA  1 
ATOM   349  C C   . GLU C 2 8   ? -78.974 -2.509  -71.156  1.00 54.06  ? 20   GLU B C   1 
ATOM   350  O O   . GLU C 2 8   ? -79.041 -1.413  -71.726  1.00 53.78  ? 20   GLU B O   1 
ATOM   351  C CB  . GLU C 2 8   ? -79.330 -4.471  -72.672  1.00 74.70  ? 20   GLU B CB  1 
ATOM   352  C CG  . GLU C 2 8   ? -78.708 -5.365  -73.731  1.00 73.78  ? 20   GLU B CG  1 
ATOM   353  C CD  . GLU C 2 8   ? -79.741 -6.141  -74.520  1.00 87.04  ? 20   GLU B CD  1 
ATOM   354  O OE1 . GLU C 2 8   ? -80.772 -6.529  -73.929  1.00 89.93  ? 20   GLU B OE1 1 
ATOM   355  O OE2 . GLU C 2 8   ? -79.522 -6.366  -75.729  1.00 95.59  ? 20   GLU B OE2 1 
ATOM   356  N N   . LYS C 2 9   ? -79.476 -2.711  -69.936  1.00 51.72  ? 21   LYS B N   1 
ATOM   357  C CA  . LYS C 2 9   ? -80.037 -1.595  -69.182  1.00 56.81  ? 21   LYS B CA  1 
ATOM   358  C C   . LYS C 2 9   ? -78.975 -0.538  -68.909  1.00 56.08  ? 21   LYS B C   1 
ATOM   359  O O   . LYS C 2 9   ? -79.248 0.665   -68.991  1.00 59.85  ? 21   LYS B O   1 
ATOM   360  C CB  . LYS C 2 9   ? -80.652 -2.097  -67.877  1.00 61.85  ? 21   LYS B CB  1 
ATOM   361  C CG  . LYS C 2 9   ? -82.132 -1.785  -67.734  1.00 72.03  ? 21   LYS B CG  1 
ATOM   362  C CD  . LYS C 2 9   ? -82.843 -2.840  -66.901  1.00 79.18  ? 21   LYS B CD  1 
ATOM   363  C CE  . LYS C 2 9   ? -84.191 -2.337  -66.408  1.00 79.04  ? 21   LYS B CE  1 
ATOM   364  N NZ  . LYS C 2 9   ? -85.156 -3.449  -66.184  1.00 66.63  ? 21   LYS B NZ  1 
ATOM   365  N N   . ILE C 2 10  ? -77.753 -0.972  -68.595  1.00 54.00  ? 22   ILE B N   1 
ATOM   366  C CA  . ILE C 2 10  ? -76.654 -0.029  -68.424  1.00 48.01  ? 22   ILE B CA  1 
ATOM   367  C C   . ILE C 2 10  ? -76.275 0.596   -69.761  1.00 45.51  ? 22   ILE B C   1 
ATOM   368  O O   . ILE C 2 10  ? -76.054 1.810   -69.853  1.00 41.73  ? 22   ILE B O   1 
ATOM   369  C CB  . ILE C 2 10  ? -75.450 -0.727  -67.768  1.00 41.75  ? 22   ILE B CB  1 
ATOM   370  C CG1 . ILE C 2 10  ? -75.881 -1.421  -66.474  1.00 63.28  ? 22   ILE B CG1 1 
ATOM   371  C CG2 . ILE C 2 10  ? -74.328 0.271   -67.521  1.00 48.12  ? 22   ILE B CG2 1 
ATOM   372  C CD1 . ILE C 2 10  ? -75.847 -0.529  -65.250  1.00 86.85  ? 22   ILE B CD1 1 
ATOM   373  N N   . TYR C 2 11  ? -76.190 -0.223  -70.814  1.00 43.89  ? 23   TYR B N   1 
ATOM   374  C CA  . TYR C 2 11  ? -75.840 0.294   -72.134  1.00 38.77  ? 23   TYR B CA  1 
ATOM   375  C C   . TYR C 2 11  ? -76.770 1.427   -72.542  1.00 49.22  ? 23   TYR B C   1 
ATOM   376  O O   . TYR C 2 11  ? -76.320 2.464   -73.042  1.00 60.14  ? 23   TYR B O   1 
ATOM   377  C CB  . TYR C 2 11  ? -75.888 -0.829  -73.173  1.00 31.58  ? 23   TYR B CB  1 
ATOM   378  C CG  . TYR C 2 11  ? -74.829 -1.897  -73.008  1.00 37.21  ? 23   TYR B CG  1 
ATOM   379  C CD1 . TYR C 2 11  ? -73.683 -1.665  -72.257  1.00 47.54  ? 23   TYR B CD1 1 
ATOM   380  C CD2 . TYR C 2 11  ? -74.980 -3.145  -73.601  1.00 39.52  ? 23   TYR B CD2 1 
ATOM   381  C CE1 . TYR C 2 11  ? -72.717 -2.646  -72.106  1.00 46.15  ? 23   TYR B CE1 1 
ATOM   382  C CE2 . TYR C 2 11  ? -74.021 -4.129  -73.456  1.00 45.87  ? 23   TYR B CE2 1 
ATOM   383  C CZ  . TYR C 2 11  ? -72.891 -3.875  -72.706  1.00 49.08  ? 23   TYR B CZ  1 
ATOM   384  O OH  . TYR C 2 11  ? -71.932 -4.851  -72.557  1.00 52.25  ? 23   TYR B OH  1 
ATOM   385  N N   . GLN C 2 12  ? -78.073 1.255   -72.316  1.00 54.54  ? 24   GLN B N   1 
ATOM   386  C CA  . GLN C 2 12  ? -79.025 2.294   -72.688  1.00 45.65  ? 24   GLN B CA  1 
ATOM   387  C C   . GLN C 2 12  ? -78.894 3.512   -71.783  1.00 43.82  ? 24   GLN B C   1 
ATOM   388  O O   . GLN C 2 12  ? -78.988 4.652   -72.255  1.00 52.38  ? 24   GLN B O   1 
ATOM   389  C CB  . GLN C 2 12  ? -80.448 1.744   -72.647  1.00 50.62  ? 24   GLN B CB  1 
ATOM   390  C CG  . GLN C 2 12  ? -81.512 2.797   -72.876  1.00 65.15  ? 24   GLN B CG  1 
ATOM   391  C CD  . GLN C 2 12  ? -82.911 2.221   -72.867  1.00 92.01  ? 24   GLN B CD  1 
ATOM   392  O OE1 . GLN C 2 12  ? -83.159 1.174   -72.267  1.00 92.11  ? 24   GLN B OE1 1 
ATOM   393  N NE2 . GLN C 2 12  ? -83.836 2.904   -73.532  1.00 102.30 ? 24   GLN B NE2 1 
ATOM   394  N N   . TRP C 2 13  ? -78.679 3.295   -70.483  1.00 39.86  ? 25   TRP B N   1 
ATOM   395  C CA  . TRP C 2 13  ? -78.520 4.419   -69.563  1.00 43.49  ? 25   TRP B CA  1 
ATOM   396  C C   . TRP C 2 13  ? -77.339 5.290   -69.968  1.00 49.53  ? 25   TRP B C   1 
ATOM   397  O O   . TRP C 2 13  ? -77.455 6.519   -70.030  1.00 54.27  ? 25   TRP B O   1 
ATOM   398  C CB  . TRP C 2 13  ? -78.349 3.914   -68.131  1.00 37.82  ? 25   TRP B CB  1 
ATOM   399  C CG  . TRP C 2 13  ? -79.639 3.550   -67.472  1.00 47.74  ? 25   TRP B CG  1 
ATOM   400  C CD1 . TRP C 2 13  ? -80.856 4.131   -67.676  1.00 46.45  ? 25   TRP B CD1 1 
ATOM   401  C CD2 . TRP C 2 13  ? -79.845 2.516   -66.501  1.00 61.68  ? 25   TRP B CD2 1 
ATOM   402  N NE1 . TRP C 2 13  ? -81.808 3.525   -66.891  1.00 54.61  ? 25   TRP B NE1 1 
ATOM   403  C CE2 . TRP C 2 13  ? -81.213 2.529   -66.162  1.00 57.57  ? 25   TRP B CE2 1 
ATOM   404  C CE3 . TRP C 2 13  ? -79.006 1.580   -65.887  1.00 58.34  ? 25   TRP B CE3 1 
ATOM   405  C CZ2 . TRP C 2 13  ? -81.761 1.642   -65.236  1.00 64.33  ? 25   TRP B CZ2 1 
ATOM   406  C CZ3 . TRP C 2 13  ? -79.551 0.703   -64.967  1.00 60.04  ? 25   TRP B CZ3 1 
ATOM   407  C CH2 . TRP C 2 13  ? -80.915 0.741   -64.650  1.00 66.99  ? 25   TRP B CH2 1 
ATOM   408  N N   . ILE C 2 14  ? -76.193 4.666   -70.255  1.00 44.90  ? 26   ILE B N   1 
ATOM   409  C CA  . ILE C 2 14  ? -75.031 5.411   -70.735  1.00 36.07  ? 26   ILE B CA  1 
ATOM   410  C C   . ILE C 2 14  ? -75.406 6.234   -71.960  1.00 34.53  ? 26   ILE B C   1 
ATOM   411  O O   . ILE C 2 14  ? -75.107 7.432   -72.046  1.00 40.57  ? 26   ILE B O   1 
ATOM   412  C CB  . ILE C 2 14  ? -73.866 4.452   -71.039  1.00 34.26  ? 26   ILE B CB  1 
ATOM   413  C CG1 . ILE C 2 14  ? -73.250 3.923   -69.740  1.00 33.47  ? 26   ILE B CG1 1 
ATOM   414  C CG2 . ILE C 2 14  ? -72.816 5.147   -71.895  1.00 40.47  ? 26   ILE B CG2 1 
ATOM   415  C CD1 . ILE C 2 14  ? -71.837 3.379   -69.903  1.00 28.14  ? 26   ILE B CD1 1 
ATOM   416  N N   . ASN C 2 15  ? -76.080 5.603   -72.923  1.00 40.42  ? 27   ASN B N   1 
ATOM   417  C CA  . ASN C 2 15  ? -76.558 6.338   -74.088  1.00 48.22  ? 27   ASN B CA  1 
ATOM   418  C C   . ASN C 2 15  ? -77.511 7.453   -73.687  1.00 45.19  ? 27   ASN B C   1 
ATOM   419  O O   . ASN C 2 15  ? -77.521 8.519   -74.313  1.00 53.95  ? 27   ASN B O   1 
ATOM   420  C CB  . ASN C 2 15  ? -77.245 5.387   -75.066  1.00 24.02  ? 27   ASN B CB  1 
ATOM   421  C CG  . ASN C 2 15  ? -76.281 4.780   -76.054  1.00 33.79  ? 27   ASN B CG  1 
ATOM   422  O OD1 . ASN C 2 15  ? -75.661 5.487   -76.848  1.00 59.73  ? 27   ASN B OD1 1 
ATOM   423  N ND2 . ASN C 2 15  ? -76.148 3.460   -76.014  1.00 43.51  ? 27   ASN B ND2 1 
ATOM   424  N N   . GLU C 2 16  ? -78.308 7.230   -72.646  1.00 41.88  ? 28   GLU B N   1 
ATOM   425  C CA  . GLU C 2 16  ? -79.283 8.216   -72.208  1.00 48.11  ? 28   GLU B CA  1 
ATOM   426  C C   . GLU C 2 16  ? -78.661 9.366   -71.430  1.00 51.01  ? 28   GLU B C   1 
ATOM   427  O O   . GLU C 2 16  ? -79.370 10.325  -71.106  1.00 52.63  ? 28   GLU B O   1 
ATOM   428  C CB  . GLU C 2 16  ? -80.361 7.538   -71.361  1.00 52.26  ? 28   GLU B CB  1 
ATOM   429  C CG  . GLU C 2 16  ? -81.391 6.783   -72.183  1.00 42.17  ? 28   GLU B CG  1 
ATOM   430  C CD  . GLU C 2 16  ? -82.407 6.062   -71.325  1.00 60.78  ? 28   GLU B CD  1 
ATOM   431  O OE1 . GLU C 2 16  ? -82.368 6.225   -70.086  1.00 63.85  ? 28   GLU B OE1 1 
ATOM   432  O OE2 . GLU C 2 16  ? -83.248 5.335   -71.891  1.00 79.20  ? 28   GLU B OE2 1 
ATOM   433  N N   . LEU C 2 17  ? -77.363 9.297   -71.118  1.00 51.17  ? 29   LEU B N   1 
ATOM   434  C CA  . LEU C 2 17  ? -76.697 10.427  -70.479  1.00 47.82  ? 29   LEU B CA  1 
ATOM   435  C C   . LEU C 2 17  ? -76.574 11.625  -71.411  1.00 48.18  ? 29   LEU B C   1 
ATOM   436  O O   . LEU C 2 17  ? -76.474 12.759  -70.932  1.00 44.09  ? 29   LEU B O   1 
ATOM   437  C CB  . LEU C 2 17  ? -75.306 10.028  -69.984  1.00 34.77  ? 29   LEU B CB  1 
ATOM   438  C CG  . LEU C 2 17  ? -75.138 9.653   -68.509  1.00 43.22  ? 29   LEU B CG  1 
ATOM   439  C CD1 . LEU C 2 17  ? -75.698 8.284   -68.229  1.00 51.08  ? 29   LEU B CD1 1 
ATOM   440  C CD2 . LEU C 2 17  ? -73.683 9.727   -68.076  1.00 52.79  ? 29   LEU B CD2 1 
ATOM   441  N N   . SER C 2 18  ? -76.584 11.404  -72.726  1.00 42.74  ? 30   SER B N   1 
ATOM   442  C CA  . SER C 2 18  ? -76.364 12.497  -73.668  1.00 48.49  ? 30   SER B CA  1 
ATOM   443  C C   . SER C 2 18  ? -77.478 13.535  -73.586  1.00 47.89  ? 30   SER B C   1 
ATOM   444  O O   . SER C 2 18  ? -77.248 14.684  -73.193  1.00 45.78  ? 30   SER B O   1 
ATOM   445  C CB  . SER C 2 18  ? -76.241 11.943  -75.089  1.00 74.99  ? 30   SER B CB  1 
ATOM   446  O OG  . SER C 2 18  ? -76.192 12.985  -76.048  1.00 74.09  ? 30   SER B OG  1 
ATOM   447  N N   . SER C 2 19  ? -78.692 13.143  -73.957  1.00 48.62  ? 31   SER B N   1 
ATOM   448  C CA  . SER C 2 19  ? -79.810 14.076  -73.982  1.00 38.99  ? 31   SER B CA  1 
ATOM   449  C C   . SER C 2 19  ? -80.109 14.591  -72.577  1.00 47.28  ? 31   SER B C   1 
ATOM   450  O O   . SER C 2 19  ? -80.158 13.796  -71.627  1.00 63.62  ? 31   SER B O   1 
ATOM   451  C CB  . SER C 2 19  ? -81.050 13.403  -74.566  1.00 50.91  ? 31   SER B CB  1 
ATOM   452  O OG  . SER C 2 19  ? -82.228 14.068  -74.145  1.00 65.11  ? 31   SER B OG  1 
ATOM   453  N N   . PRO C 2 20  ? -80.313 15.899  -72.401  1.00 39.08  ? 32   PRO B N   1 
ATOM   454  C CA  . PRO C 2 20  ? -80.653 16.417  -71.066  1.00 44.71  ? 32   PRO B CA  1 
ATOM   455  C C   . PRO C 2 20  ? -82.009 15.959  -70.558  1.00 48.86  ? 32   PRO B C   1 
ATOM   456  O O   . PRO C 2 20  ? -82.259 16.046  -69.349  1.00 59.81  ? 32   PRO B O   1 
ATOM   457  C CB  . PRO C 2 20  ? -80.621 17.940  -71.263  1.00 45.52  ? 32   PRO B CB  1 
ATOM   458  C CG  . PRO C 2 20  ? -79.763 18.147  -72.475  1.00 51.07  ? 32   PRO B CG  1 
ATOM   459  C CD  . PRO C 2 20  ? -80.074 16.981  -73.368  1.00 54.51  ? 32   PRO B CD  1 
ATOM   460  N N   . GLU C 2 21  ? -82.893 15.480  -71.435  1.00 41.36  ? 33   GLU B N   1 
ATOM   461  C CA  . GLU C 2 21  ? -84.194 15.007  -70.979  1.00 50.33  ? 33   GLU B CA  1 
ATOM   462  C C   . GLU C 2 21  ? -84.079 13.679  -70.241  1.00 49.91  ? 33   GLU B C   1 
ATOM   463  O O   . GLU C 2 21  ? -84.873 13.402  -69.335  1.00 58.12  ? 33   GLU B O   1 
ATOM   464  C CB  . GLU C 2 21  ? -85.145 14.884  -72.171  1.00 73.03  ? 33   GLU B CB  1 
ATOM   465  C CG  . GLU C 2 21  ? -86.489 14.249  -71.855  1.00 96.00  ? 33   GLU B CG  1 
ATOM   466  C CD  . GLU C 2 21  ? -87.012 13.392  -72.994  1.00 111.88 ? 33   GLU B CD  1 
ATOM   467  O OE1 . GLU C 2 21  ? -86.519 13.544  -74.132  1.00 110.94 ? 33   GLU B OE1 1 
ATOM   468  O OE2 . GLU C 2 21  ? -87.916 12.566  -72.749  1.00 113.66 ? 33   GLU B OE2 1 
ATOM   469  N N   . THR C 2 22  ? -83.089 12.860  -70.593  1.00 45.24  ? 34   THR B N   1 
ATOM   470  C CA  . THR C 2 22  ? -82.948 11.519  -70.043  1.00 50.10  ? 34   THR B CA  1 
ATOM   471  C C   . THR C 2 22  ? -81.729 11.369  -69.141  1.00 45.25  ? 34   THR B C   1 
ATOM   472  O O   . THR C 2 22  ? -81.435 10.255  -68.692  1.00 50.45  ? 34   THR B O   1 
ATOM   473  C CB  . THR C 2 22  ? -82.881 10.495  -71.180  1.00 51.67  ? 34   THR B CB  1 
ATOM   474  O OG1 . THR C 2 22  ? -81.549 10.449  -71.702  1.00 47.69  ? 34   THR B OG1 1 
ATOM   475  C CG2 . THR C 2 22  ? -83.842 10.874  -72.296  1.00 54.98  ? 34   THR B CG2 1 
ATOM   476  N N   . ARG C 2 23  ? -81.018 12.462  -68.854  1.00 42.09  ? 35   ARG B N   1 
ATOM   477  C CA  . ARG C 2 23  ? -79.783 12.360  -68.081  1.00 49.54  ? 35   ARG B CA  1 
ATOM   478  C C   . ARG C 2 23  ? -80.054 12.078  -66.610  1.00 42.30  ? 35   ARG B C   1 
ATOM   479  O O   . ARG C 2 23  ? -79.349 11.272  -65.989  1.00 42.40  ? 35   ARG B O   1 
ATOM   480  C CB  . ARG C 2 23  ? -78.960 13.639  -68.231  1.00 48.68  ? 35   ARG B CB  1 
ATOM   481  C CG  . ARG C 2 23  ? -77.724 13.672  -67.347  1.00 43.98  ? 35   ARG B CG  1 
ATOM   482  C CD  . ARG C 2 23  ? -76.475 13.971  -68.149  1.00 48.81  ? 35   ARG B CD  1 
ATOM   483  N NE  . ARG C 2 23  ? -76.720 14.916  -69.232  1.00 41.68  ? 35   ARG B NE  1 
ATOM   484  C CZ  . ARG C 2 23  ? -76.568 16.230  -69.129  1.00 43.30  ? 35   ARG B CZ  1 
ATOM   485  N NH1 . ARG C 2 23  ? -76.153 16.792  -68.005  1.00 57.71  ? 35   ARG B NH1 1 
ATOM   486  N NH2 . ARG C 2 23  ? -76.832 16.999  -70.181  1.00 45.22  ? 35   ARG B NH2 1 
ATOM   487  N N   . GLU C 2 24  ? -81.066 12.731  -66.037  1.00 44.92  ? 36   GLU B N   1 
ATOM   488  C CA  . GLU C 2 24  ? -81.284 12.651  -64.596  1.00 47.98  ? 36   GLU B CA  1 
ATOM   489  C C   . GLU C 2 24  ? -81.498 11.210  -64.146  1.00 37.64  ? 36   GLU B C   1 
ATOM   490  O O   . GLU C 2 24  ? -80.868 10.749  -63.187  1.00 38.19  ? 36   GLU B O   1 
ATOM   491  C CB  . GLU C 2 24  ? -82.472 13.525  -64.201  1.00 47.06  ? 36   GLU B CB  1 
ATOM   492  C CG  . GLU C 2 24  ? -82.680 13.630  -62.704  1.00 57.22  ? 36   GLU B CG  1 
ATOM   493  C CD  . GLU C 2 24  ? -83.761 14.622  -62.339  1.00 73.60  ? 36   GLU B CD  1 
ATOM   494  O OE1 . GLU C 2 24  ? -84.287 15.292  -63.252  1.00 93.92  ? 36   GLU B OE1 1 
ATOM   495  O OE2 . GLU C 2 24  ? -84.092 14.724  -61.140  1.00 85.89  ? 36   GLU B OE2 1 
ATOM   496  N N   . ASN C 2 25  ? -82.384 10.481  -64.831  1.00 39.53  ? 37   ASN B N   1 
ATOM   497  C CA  . ASN C 2 25  ? -82.637 9.093   -64.459  1.00 36.57  ? 37   ASN B CA  1 
ATOM   498  C C   . ASN C 2 25  ? -81.390 8.239   -64.644  1.00 42.23  ? 37   ASN B C   1 
ATOM   499  O O   . ASN C 2 25  ? -81.044 7.433   -63.772  1.00 48.73  ? 37   ASN B O   1 
ATOM   500  C CB  . ASN C 2 25  ? -83.798 8.529   -65.278  1.00 49.18  ? 37   ASN B CB  1 
ATOM   501  C CG  . ASN C 2 25  ? -84.291 7.189   -64.752  1.00 61.93  ? 37   ASN B CG  1 
ATOM   502  O OD1 . ASN C 2 25  ? -84.909 7.115   -63.688  1.00 59.67  ? 37   ASN B OD1 1 
ATOM   503  N ND2 . ASN C 2 25  ? -84.017 6.122   -65.496  1.00 57.99  ? 37   ASN B ND2 1 
ATOM   504  N N   . ALA C 2 26  ? -80.696 8.407   -65.772  1.00 33.94  ? 38   ALA B N   1 
ATOM   505  C CA  . ALA C 2 26  ? -79.497 7.614   -66.017  1.00 38.15  ? 38   ALA B CA  1 
ATOM   506  C C   . ALA C 2 26  ? -78.366 7.989   -65.065  1.00 42.45  ? 38   ALA B C   1 
ATOM   507  O O   . ALA C 2 26  ? -77.572 7.124   -64.681  1.00 43.41  ? 38   ALA B O   1 
ATOM   508  C CB  . ALA C 2 26  ? -79.060 7.770   -67.470  1.00 52.41  ? 38   ALA B CB  1 
ATOM   509  N N   . LEU C 2 27  ? -78.276 9.262   -64.671  1.00 38.84  ? 39   LEU B N   1 
ATOM   510  C CA  . LEU C 2 27  ? -77.317 9.643   -63.638  1.00 28.39  ? 39   LEU B CA  1 
ATOM   511  C C   . LEU C 2 27  ? -77.601 8.912   -62.335  1.00 37.80  ? 39   LEU B C   1 
ATOM   512  O O   . LEU C 2 27  ? -76.682 8.405   -61.682  1.00 42.65  ? 39   LEU B O   1 
ATOM   513  C CB  . LEU C 2 27  ? -77.351 11.154  -63.414  1.00 34.44  ? 39   LEU B CB  1 
ATOM   514  C CG  . LEU C 2 27  ? -76.407 12.013  -64.252  1.00 29.88  ? 39   LEU B CG  1 
ATOM   515  C CD1 . LEU C 2 27  ? -76.302 13.410  -63.660  1.00 23.41  ? 39   LEU B CD1 1 
ATOM   516  C CD2 . LEU C 2 27  ? -75.038 11.361  -64.346  1.00 39.04  ? 39   LEU B CD2 1 
ATOM   517  N N   . LEU C 2 28  ? -78.875 8.849   -61.942  1.00 38.30  ? 40   LEU B N   1 
ATOM   518  C CA  . LEU C 2 28  ? -79.255 8.127   -60.734  1.00 31.60  ? 40   LEU B CA  1 
ATOM   519  C C   . LEU C 2 28  ? -78.960 6.639   -60.876  1.00 43.30  ? 40   LEU B C   1 
ATOM   520  O O   . LEU C 2 28  ? -78.278 6.045   -60.033  1.00 49.49  ? 40   LEU B O   1 
ATOM   521  C CB  . LEU C 2 28  ? -80.740 8.368   -60.443  1.00 31.17  ? 40   LEU B CB  1 
ATOM   522  C CG  . LEU C 2 28  ? -81.466 7.931   -59.161  1.00 48.03  ? 40   LEU B CG  1 
ATOM   523  C CD1 . LEU C 2 28  ? -82.911 8.409   -59.230  1.00 35.64  ? 40   LEU B CD1 1 
ATOM   524  C CD2 . LEU C 2 28  ? -81.437 6.425   -58.891  1.00 66.21  ? 40   LEU B CD2 1 
ATOM   525  N N   . GLU C 2 29  ? -79.472 6.020   -61.942  1.00 39.76  ? 41   GLU B N   1 
ATOM   526  C CA  . GLU C 2 29  ? -79.405 4.567   -62.054  1.00 45.86  ? 41   GLU B CA  1 
ATOM   527  C C   . GLU C 2 29  ? -77.979 4.069   -62.244  1.00 50.10  ? 41   GLU B C   1 
ATOM   528  O O   . GLU C 2 29  ? -77.667 2.935   -61.865  1.00 62.39  ? 41   GLU B O   1 
ATOM   529  C CB  . GLU C 2 29  ? -80.292 4.087   -63.201  1.00 56.38  ? 41   GLU B CB  1 
ATOM   530  C CG  . GLU C 2 29  ? -81.777 4.348   -62.983  1.00 66.79  ? 41   GLU B CG  1 
ATOM   531  C CD  . GLU C 2 29  ? -82.472 3.219   -62.244  1.00 72.33  ? 41   GLU B CD  1 
ATOM   532  O OE1 . GLU C 2 29  ? -81.776 2.409   -61.595  1.00 71.33  ? 41   GLU B OE1 1 
ATOM   533  O OE2 . GLU C 2 29  ? -83.718 3.143   -62.309  1.00 65.26  ? 41   GLU B OE2 1 
ATOM   534  N N   . LEU C 2 30  ? -77.101 4.887   -62.823  1.00 42.29  ? 42   LEU B N   1 
ATOM   535  C CA  . LEU C 2 30  ? -75.716 4.470   -62.992  1.00 39.16  ? 42   LEU B CA  1 
ATOM   536  C C   . LEU C 2 30  ? -74.866 4.753   -61.762  1.00 44.18  ? 42   LEU B C   1 
ATOM   537  O O   . LEU C 2 30  ? -73.928 3.997   -61.482  1.00 58.99  ? 42   LEU B O   1 
ATOM   538  C CB  . LEU C 2 30  ? -75.102 5.143   -64.220  1.00 30.66  ? 42   LEU B CB  1 
ATOM   539  C CG  . LEU C 2 30  ? -75.703 4.684   -65.552  1.00 31.02  ? 42   LEU B CG  1 
ATOM   540  C CD1 . LEU C 2 30  ? -74.878 5.197   -66.713  1.00 37.71  ? 42   LEU B CD1 1 
ATOM   541  C CD2 . LEU C 2 30  ? -75.825 3.168   -65.609  1.00 31.31  ? 42   LEU B CD2 1 
ATOM   542  N N   . SER C 2 31  ? -75.174 5.811   -61.010  1.00 33.65  ? 43   SER B N   1 
ATOM   543  C CA  . SER C 2 31  ? -74.440 6.069   -59.777  1.00 35.31  ? 43   SER B CA  1 
ATOM   544  C C   . SER C 2 31  ? -74.687 5.002   -58.721  1.00 51.47  ? 43   SER B C   1 
ATOM   545  O O   . SER C 2 31  ? -73.978 4.980   -57.708  1.00 67.76  ? 43   SER B O   1 
ATOM   546  C CB  . SER C 2 31  ? -74.807 7.447   -59.224  1.00 38.69  ? 43   SER B CB  1 
ATOM   547  O OG  . SER C 2 31  ? -76.210 7.633   -59.224  1.00 54.47  ? 43   SER B OG  1 
ATOM   548  N N   . LYS C 2 32  ? -75.669 4.124   -58.931  1.00 48.34  ? 44   LYS B N   1 
ATOM   549  C CA  . LYS C 2 32  ? -75.944 3.024   -58.016  1.00 49.33  ? 44   LYS B CA  1 
ATOM   550  C C   . LYS C 2 32  ? -75.181 1.758   -58.381  1.00 47.24  ? 44   LYS B C   1 
ATOM   551  O O   . LYS C 2 32  ? -74.781 1.003   -57.486  1.00 54.11  ? 44   LYS B O   1 
ATOM   552  C CB  . LYS C 2 32  ? -77.446 2.723   -57.994  1.00 39.69  ? 44   LYS B CB  1 
ATOM   553  C CG  . LYS C 2 32  ? -78.301 3.856   -57.446  1.00 49.67  ? 44   LYS B CG  1 
ATOM   554  C CD  . LYS C 2 32  ? -79.682 3.367   -57.032  1.00 72.22  ? 44   LYS B CD  1 
ATOM   555  C CE  . LYS C 2 32  ? -79.589 2.219   -56.037  1.00 91.11  ? 44   LYS B CE  1 
ATOM   556  N NZ  . LYS C 2 32  ? -80.782 2.142   -55.148  1.00 67.40  ? 44   LYS B NZ  1 
ATOM   557  N N   . LYS C 2 33  ? -74.968 1.509   -59.672  1.00 44.56  ? 45   LYS B N   1 
ATOM   558  C CA  . LYS C 2 33  ? -74.252 0.330   -60.137  1.00 49.81  ? 45   LYS B CA  1 
ATOM   559  C C   . LYS C 2 33  ? -72.762 0.587   -60.316  1.00 50.94  ? 45   LYS B C   1 
ATOM   560  O O   . LYS C 2 33  ? -72.079 -0.207  -60.975  1.00 43.48  ? 45   LYS B O   1 
ATOM   561  C CB  . LYS C 2 33  ? -74.862 -0.162  -61.452  1.00 52.73  ? 45   LYS B CB  1 
ATOM   562  C CG  . LYS C 2 33  ? -76.368 0.014   -61.528  1.00 52.02  ? 45   LYS B CG  1 
ATOM   563  C CD  . LYS C 2 33  ? -77.077 -1.310  -61.751  1.00 63.28  ? 45   LYS B CD  1 
ATOM   564  C CE  . LYS C 2 33  ? -78.584 -1.151  -61.626  1.00 73.48  ? 45   LYS B CE  1 
ATOM   565  N NZ  . LYS C 2 33  ? -79.096 -1.750  -60.364  1.00 75.69  ? 45   LYS B NZ  1 
ATOM   566  N N   . ARG C 2 34  ? -72.250 1.678   -59.741  1.00 56.90  ? 46   ARG B N   1 
ATOM   567  C CA  . ARG C 2 34  ? -70.858 2.067   -59.949  1.00 51.86  ? 46   ARG B CA  1 
ATOM   568  C C   . ARG C 2 34  ? -69.900 0.979   -59.482  1.00 63.65  ? 46   ARG B C   1 
ATOM   569  O O   . ARG C 2 34  ? -68.979 0.590   -60.210  1.00 52.30  ? 46   ARG B O   1 
ATOM   570  C CB  . ARG C 2 34  ? -70.589 3.382   -59.222  1.00 43.62  ? 46   ARG B CB  1 
ATOM   571  C CG  . ARG C 2 34  ? -69.132 3.776   -59.115  1.00 65.90  ? 46   ARG B CG  1 
ATOM   572  C CD  . ARG C 2 34  ? -68.964 5.249   -58.739  1.00 72.46  ? 46   ARG B CD  1 
ATOM   573  N NE  . ARG C 2 34  ? -69.197 5.536   -57.326  1.00 57.76  ? 46   ARG B NE  1 
ATOM   574  C CZ  . ARG C 2 34  ? -70.389 5.725   -56.770  1.00 60.40  ? 46   ARG B CZ  1 
ATOM   575  N NH1 . ARG C 2 34  ? -71.503 5.720   -57.488  1.00 54.10  ? 46   ARG B NH1 1 
ATOM   576  N NH2 . ARG C 2 34  ? -70.466 5.953   -55.462  1.00 48.56  ? 46   ARG B NH2 1 
ATOM   577  N N   . GLU C 2 35  ? -70.102 0.476   -58.264  1.00 72.91  ? 47   GLU B N   1 
ATOM   578  C CA  . GLU C 2 35  ? -69.309 -0.643  -57.778  1.00 65.00  ? 47   GLU B CA  1 
ATOM   579  C C   . GLU C 2 35  ? -69.811 -1.980  -58.304  1.00 59.32  ? 47   GLU B C   1 
ATOM   580  O O   . GLU C 2 35  ? -69.068 -2.966  -58.264  1.00 57.35  ? 47   GLU B O   1 
ATOM   581  C CB  . GLU C 2 35  ? -69.307 -0.657  -56.249  1.00 60.21  ? 47   GLU B CB  1 
ATOM   582  C CG  . GLU C 2 35  ? -69.124 0.714   -55.624  1.00 66.23  ? 47   GLU B CG  1 
ATOM   583  C CD  . GLU C 2 35  ? -67.692 1.205   -55.710  1.00 89.68  ? 47   GLU B CD  1 
ATOM   584  O OE1 . GLU C 2 35  ? -66.771 0.359   -55.700  1.00 105.82 ? 47   GLU B OE1 1 
ATOM   585  O OE2 . GLU C 2 35  ? -67.487 2.435   -55.788  1.00 92.75  ? 47   GLU B OE2 1 
ATOM   586  N N   . SER C 2 36  ? -71.047 -2.031  -58.805  1.00 48.89  ? 48   SER B N   1 
ATOM   587  C CA  . SER C 2 36  ? -71.609 -3.296  -59.265  1.00 46.83  ? 48   SER B CA  1 
ATOM   588  C C   . SER C 2 36  ? -70.962 -3.755  -60.567  1.00 54.18  ? 48   SER B C   1 
ATOM   589  O O   . SER C 2 36  ? -70.617 -4.933  -60.713  1.00 50.40  ? 48   SER B O   1 
ATOM   590  C CB  . SER C 2 36  ? -73.123 -3.164  -59.432  1.00 57.11  ? 48   SER B CB  1 
ATOM   591  O OG  . SER C 2 36  ? -73.610 -4.046  -60.428  1.00 70.24  ? 48   SER B OG  1 
ATOM   592  N N   . VAL C 2 37  ? -70.788 -2.849  -61.517  1.00 57.15  ? 49   VAL B N   1 
ATOM   593  C CA  . VAL C 2 37  ? -70.229 -3.172  -62.827  1.00 44.77  ? 49   VAL B CA  1 
ATOM   594  C C   . VAL C 2 37  ? -68.778 -2.698  -62.869  1.00 51.45  ? 49   VAL B C   1 
ATOM   595  O O   . VAL C 2 37  ? -68.482 -1.603  -62.368  1.00 46.44  ? 49   VAL B O   1 
ATOM   596  C CB  . VAL C 2 37  ? -71.065 -2.555  -63.968  1.00 38.53  ? 49   VAL B CB  1 
ATOM   597  C CG1 . VAL C 2 37  ? -70.737 -1.094  -64.193  1.00 36.78  ? 49   VAL B CG1 1 
ATOM   598  C CG2 . VAL C 2 37  ? -70.879 -3.348  -65.250  1.00 45.24  ? 49   VAL B CG2 1 
ATOM   599  N N   . PRO C 2 38  ? -67.848 -3.504  -63.387  1.00 50.60  ? 50   PRO B N   1 
ATOM   600  C CA  . PRO C 2 38  ? -66.428 -3.133  -63.319  1.00 52.05  ? 50   PRO B CA  1 
ATOM   601  C C   . PRO C 2 38  ? -66.007 -2.169  -64.413  1.00 52.30  ? 50   PRO B C   1 
ATOM   602  O O   . PRO C 2 38  ? -65.269 -1.210  -64.168  1.00 47.79  ? 50   PRO B O   1 
ATOM   603  C CB  . PRO C 2 38  ? -65.713 -4.485  -63.478  1.00 53.64  ? 50   PRO B CB  1 
ATOM   604  C CG  . PRO C 2 38  ? -66.755 -5.508  -63.100  1.00 46.94  ? 50   PRO B CG  1 
ATOM   605  C CD  . PRO C 2 38  ? -68.008 -4.935  -63.686  1.00 44.51  ? 50   PRO B CD  1 
ATOM   606  N N   . ASP C 2 39  ? -66.475 -2.426  -65.632  1.00 49.38  ? 51   ASP B N   1 
ATOM   607  C CA  . ASP C 2 39  ? -66.014 -1.723  -66.818  1.00 36.69  ? 51   ASP B CA  1 
ATOM   608  C C   . ASP C 2 39  ? -66.789 -0.440  -67.089  1.00 39.41  ? 51   ASP B C   1 
ATOM   609  O O   . ASP C 2 39  ? -66.788 0.040   -68.229  1.00 52.06  ? 51   ASP B O   1 
ATOM   610  C CB  . ASP C 2 39  ? -66.097 -2.647  -68.037  1.00 40.79  ? 51   ASP B CB  1 
ATOM   611  C CG  . ASP C 2 39  ? -67.461 -3.296  -68.184  1.00 49.74  ? 51   ASP B CG  1 
ATOM   612  O OD1 . ASP C 2 39  ? -68.266 -3.222  -67.229  1.00 62.15  ? 51   ASP B OD1 1 
ATOM   613  O OD2 . ASP C 2 39  ? -67.731 -3.879  -69.255  1.00 59.46  ? 51   ASP B OD2 1 
ATOM   614  N N   . LEU C 2 40  ? -67.452 0.125   -66.078  1.00 40.79  ? 52   LEU B N   1 
ATOM   615  C CA  . LEU C 2 40  ? -68.212 1.349   -66.307  1.00 33.95  ? 52   LEU B CA  1 
ATOM   616  C C   . LEU C 2 40  ? -67.303 2.481   -66.761  1.00 38.48  ? 52   LEU B C   1 
ATOM   617  O O   . LEU C 2 40  ? -67.626 3.206   -67.710  1.00 47.99  ? 52   LEU B O   1 
ATOM   618  C CB  . LEU C 2 40  ? -68.970 1.750   -65.044  1.00 24.42  ? 52   LEU B CB  1 
ATOM   619  C CG  . LEU C 2 40  ? -69.843 2.995   -65.195  1.00 29.98  ? 52   LEU B CG  1 
ATOM   620  C CD1 . LEU C 2 40  ? -71.205 2.630   -65.768  1.00 32.72  ? 52   LEU B CD1 1 
ATOM   621  C CD2 . LEU C 2 40  ? -69.996 3.698   -63.853  1.00 29.10  ? 52   LEU B CD2 1 
ATOM   622  N N   . ALA C 2 41  ? -66.153 2.634   -66.110  1.00 35.20  ? 53   ALA B N   1 
ATOM   623  C CA  . ALA C 2 41  ? -65.270 3.754   -66.427  1.00 36.81  ? 53   ALA B CA  1 
ATOM   624  C C   . ALA C 2 41  ? -64.748 3.718   -67.858  1.00 34.88  ? 53   ALA B C   1 
ATOM   625  O O   . ALA C 2 41  ? -64.802 4.762   -68.532  1.00 38.80  ? 53   ALA B O   1 
ATOM   626  C CB  . ALA C 2 41  ? -64.130 3.804   -65.408  1.00 40.02  ? 53   ALA B CB  1 
ATOM   627  N N   . PRO C 2 42  ? -64.230 2.599   -68.384  1.00 30.42  ? 54   PRO B N   1 
ATOM   628  C CA  . PRO C 2 42  ? -63.854 2.604   -69.809  1.00 25.81  ? 54   PRO B CA  1 
ATOM   629  C C   . PRO C 2 42  ? -65.035 2.858   -70.724  1.00 25.02  ? 54   PRO B C   1 
ATOM   630  O O   . PRO C 2 42  ? -64.905 3.593   -71.711  1.00 36.17  ? 54   PRO B O   1 
ATOM   631  C CB  . PRO C 2 42  ? -63.252 1.208   -70.033  1.00 25.70  ? 54   PRO B CB  1 
ATOM   632  C CG  . PRO C 2 42  ? -63.602 0.410   -68.843  1.00 46.26  ? 54   PRO B CG  1 
ATOM   633  C CD  . PRO C 2 42  ? -63.829 1.351   -67.713  1.00 33.20  ? 54   PRO B CD  1 
ATOM   634  N N   . MET C 2 43  ? -66.194 2.274   -70.415  1.00 24.22  ? 55   MET B N   1 
ATOM   635  C CA  . MET C 2 43  ? -67.375 2.509   -71.238  1.00 29.95  ? 55   MET B CA  1 
ATOM   636  C C   . MET C 2 43  ? -67.815 3.965   -71.164  1.00 27.08  ? 55   MET B C   1 
ATOM   637  O O   . MET C 2 43  ? -68.218 4.551   -72.175  1.00 34.96  ? 55   MET B O   1 
ATOM   638  C CB  . MET C 2 43  ? -68.514 1.587   -70.807  1.00 34.98  ? 55   MET B CB  1 
ATOM   639  C CG  . MET C 2 43  ? -68.423 0.176   -71.365  1.00 40.19  ? 55   MET B CG  1 
ATOM   640  S SD  . MET C 2 43  ? -69.129 -1.025  -70.224  1.00 59.23  ? 55   MET B SD  1 
ATOM   641  C CE  . MET C 2 43  ? -70.835 -0.480  -70.201  1.00 40.94  ? 55   MET B CE  1 
ATOM   642  N N   . LEU C 2 44  ? -67.741 4.567   -69.974  1.00 26.47  ? 56   LEU B N   1 
ATOM   643  C CA  . LEU C 2 44  ? -68.113 5.971   -69.829  1.00 26.41  ? 56   LEU B CA  1 
ATOM   644  C C   . LEU C 2 44  ? -67.192 6.869   -70.644  1.00 33.69  ? 56   LEU B C   1 
ATOM   645  O O   . LEU C 2 44  ? -67.650 7.800   -71.318  1.00 39.18  ? 56   LEU B O   1 
ATOM   646  C CB  . LEU C 2 44  ? -68.076 6.372   -68.354  1.00 24.18  ? 56   LEU B CB  1 
ATOM   647  C CG  . LEU C 2 44  ? -69.262 5.983   -67.468  1.00 18.23  ? 56   LEU B CG  1 
ATOM   648  C CD1 . LEU C 2 44  ? -69.150 6.663   -66.117  1.00 17.97  ? 56   LEU B CD1 1 
ATOM   649  C CD2 . LEU C 2 44  ? -70.584 6.320   -68.130  1.00 20.68  ? 56   LEU B CD2 1 
ATOM   650  N N   . TRP C 2 45  ? -65.887 6.598   -70.601  1.00 33.67  ? 57   TRP B N   1 
ATOM   651  C CA  . TRP C 2 45  ? -64.927 7.446   -71.297  1.00 23.18  ? 57   TRP B CA  1 
ATOM   652  C C   . TRP C 2 45  ? -65.059 7.309   -72.810  1.00 30.06  ? 57   TRP B C   1 
ATOM   653  O O   . TRP C 2 45  ? -65.219 8.308   -73.521  1.00 42.76  ? 57   TRP B O   1 
ATOM   654  C CB  . TRP C 2 45  ? -63.511 7.099   -70.842  1.00 16.39  ? 57   TRP B CB  1 
ATOM   655  C CG  . TRP C 2 45  ? -62.475 8.038   -71.345  1.00 12.85  ? 57   TRP B CG  1 
ATOM   656  C CD1 . TRP C 2 45  ? -61.750 7.918   -72.494  1.00 22.06  ? 57   TRP B CD1 1 
ATOM   657  C CD2 . TRP C 2 45  ? -62.037 9.247   -70.717  1.00 13.81  ? 57   TRP B CD2 1 
ATOM   658  N NE1 . TRP C 2 45  ? -60.886 8.979   -72.620  1.00 25.26  ? 57   TRP B NE1 1 
ATOM   659  C CE2 . TRP C 2 45  ? -61.043 9.809   -71.542  1.00 25.85  ? 57   TRP B CE2 1 
ATOM   660  C CE3 . TRP C 2 45  ? -62.388 9.907   -69.538  1.00 21.50  ? 57   TRP B CE3 1 
ATOM   661  C CZ2 . TRP C 2 45  ? -60.398 11.003  -71.225  1.00 30.84  ? 57   TRP B CZ2 1 
ATOM   662  C CZ3 . TRP C 2 45  ? -61.746 11.092  -69.226  1.00 32.18  ? 57   TRP B CZ3 1 
ATOM   663  C CH2 . TRP C 2 45  ? -60.765 11.629  -70.068  1.00 29.30  ? 57   TRP B CH2 1 
ATOM   664  N N   . HIS C 2 46  ? -65.015 6.078   -73.320  1.00 27.73  ? 58   HIS B N   1 
ATOM   665  C CA  . HIS C 2 46  ? -64.921 5.858   -74.759  1.00 25.62  ? 58   HIS B CA  1 
ATOM   666  C C   . HIS C 2 46  ? -66.253 5.981   -75.490  1.00 32.06  ? 58   HIS B C   1 
ATOM   667  O O   . HIS C 2 46  ? -66.263 5.928   -76.725  1.00 38.52  ? 58   HIS B O   1 
ATOM   668  C CB  . HIS C 2 46  ? -64.303 4.486   -75.029  1.00 23.19  ? 58   HIS B CB  1 
ATOM   669  C CG  . HIS C 2 46  ? -62.894 4.362   -74.543  1.00 23.43  ? 58   HIS B CG  1 
ATOM   670  N ND1 . HIS C 2 46  ? -62.579 4.210   -73.211  1.00 35.36  ? 58   HIS B ND1 1 
ATOM   671  C CD2 . HIS C 2 46  ? -61.716 4.386   -75.209  1.00 30.84  ? 58   HIS B CD2 1 
ATOM   672  C CE1 . HIS C 2 46  ? -61.267 4.136   -73.076  1.00 35.76  ? 58   HIS B CE1 1 
ATOM   673  N NE2 . HIS C 2 46  ? -60.720 4.240   -74.274  1.00 31.02  ? 58   HIS B NE2 1 
ATOM   674  N N   . SER C 2 47  ? -67.365 6.140   -74.779  1.00 38.51  ? 59   SER B N   1 
ATOM   675  C CA  . SER C 2 47  ? -68.634 6.396   -75.441  1.00 32.38  ? 59   SER B CA  1 
ATOM   676  C C   . SER C 2 47  ? -68.773 7.883   -75.756  1.00 38.09  ? 59   SER B C   1 
ATOM   677  O O   . SER C 2 47  ? -68.069 8.732   -75.197  1.00 31.76  ? 59   SER B O   1 
ATOM   678  C CB  . SER C 2 47  ? -69.804 5.930   -74.577  1.00 36.42  ? 59   SER B CB  1 
ATOM   679  O OG  . SER C 2 47  ? -69.804 6.599   -73.329  1.00 37.19  ? 59   SER B OG  1 
ATOM   680  N N   . PHE C 2 48  ? -69.704 8.197   -76.654  1.00 29.02  ? 60   PHE B N   1 
ATOM   681  C CA  . PHE C 2 48  ? -69.804 9.553   -77.175  1.00 30.12  ? 60   PHE B CA  1 
ATOM   682  C C   . PHE C 2 48  ? -70.478 10.493  -76.183  1.00 31.17  ? 60   PHE B C   1 
ATOM   683  O O   . PHE C 2 48  ? -71.509 10.157  -75.589  1.00 40.93  ? 60   PHE B O   1 
ATOM   684  C CB  . PHE C 2 48  ? -70.567 9.582   -78.497  1.00 35.36  ? 60   PHE B CB  1 
ATOM   685  C CG  . PHE C 2 48  ? -70.602 10.944  -79.121  1.00 44.36  ? 60   PHE B CG  1 
ATOM   686  C CD1 . PHE C 2 48  ? -69.480 11.454  -79.755  1.00 30.21  ? 60   PHE B CD1 1 
ATOM   687  C CD2 . PHE C 2 48  ? -71.736 11.736  -79.036  1.00 47.25  ? 60   PHE B CD2 1 
ATOM   688  C CE1 . PHE C 2 48  ? -69.496 12.717  -80.315  1.00 29.67  ? 60   PHE B CE1 1 
ATOM   689  C CE2 . PHE C 2 48  ? -71.757 13.000  -79.595  1.00 41.86  ? 60   PHE B CE2 1 
ATOM   690  C CZ  . PHE C 2 48  ? -70.637 13.491  -80.235  1.00 36.22  ? 60   PHE B CZ  1 
ATOM   691  N N   . GLY C 2 49  ? -69.888 11.676  -76.011  1.00 37.74  ? 61   GLY B N   1 
ATOM   692  C CA  . GLY C 2 49  ? -70.492 12.769  -75.272  1.00 42.85  ? 61   GLY B CA  1 
ATOM   693  C C   . GLY C 2 49  ? -70.728 12.517  -73.799  1.00 44.26  ? 61   GLY B C   1 
ATOM   694  O O   . GLY C 2 49  ? -71.174 13.414  -73.077  1.00 49.36  ? 61   GLY B O   1 
ATOM   695  N N   . THR C 2 50  ? -70.426 11.304  -73.337  1.00 48.04  ? 62   THR B N   1 
ATOM   696  C CA  . THR C 2 50  ? -70.741 10.942  -71.961  1.00 30.46  ? 62   THR B CA  1 
ATOM   697  C C   . THR C 2 50  ? -69.896 11.738  -70.975  1.00 28.77  ? 62   THR B C   1 
ATOM   698  O O   . THR C 2 50  ? -70.422 12.299  -70.007  1.00 33.48  ? 62   THR B O   1 
ATOM   699  C CB  . THR C 2 50  ? -70.548 9.439   -71.766  1.00 25.55  ? 62   THR B CB  1 
ATOM   700  O OG1 . THR C 2 50  ? -71.209 8.737   -72.827  1.00 39.17  ? 62   THR B OG1 1 
ATOM   701  C CG2 . THR C 2 50  ? -71.134 9.001   -70.450  1.00 22.44  ? 62   THR B CG2 1 
ATOM   702  N N   . ILE C 2 51  ? -68.583 11.811  -71.206  1.00 21.99  ? 63   ILE B N   1 
ATOM   703  C CA  . ILE C 2 51  ? -67.732 12.592  -70.313  1.00 20.40  ? 63   ILE B CA  1 
ATOM   704  C C   . ILE C 2 51  ? -68.069 14.074  -70.425  1.00 25.50  ? 63   ILE B C   1 
ATOM   705  O O   . ILE C 2 51  ? -68.024 14.813  -69.433  1.00 21.69  ? 63   ILE B O   1 
ATOM   706  C CB  . ILE C 2 51  ? -66.246 12.317  -70.609  1.00 29.99  ? 63   ILE B CB  1 
ATOM   707  C CG1 . ILE C 2 51  ? -65.814 10.992  -69.980  1.00 17.96  ? 63   ILE B CG1 1 
ATOM   708  C CG2 . ILE C 2 51  ? -65.373 13.430  -70.059  1.00 16.29  ? 63   ILE B CG2 1 
ATOM   709  C CD1 . ILE C 2 51  ? -66.273 10.824  -68.557  1.00 26.94  ? 63   ILE B CD1 1 
ATOM   710  N N   . ALA C 2 52  ? -68.429 14.527  -71.627  1.00 23.64  ? 64   ALA B N   1 
ATOM   711  C CA  . ALA C 2 52  ? -68.868 15.908  -71.787  1.00 25.94  ? 64   ALA B CA  1 
ATOM   712  C C   . ALA C 2 52  ? -70.136 16.178  -70.986  1.00 29.29  ? 64   ALA B C   1 
ATOM   713  O O   . ALA C 2 52  ? -70.279 17.247  -70.379  1.00 24.48  ? 64   ALA B O   1 
ATOM   714  C CB  . ALA C 2 52  ? -69.087 16.220  -73.267  1.00 26.69  ? 64   ALA B CB  1 
ATOM   715  N N   . ALA C 2 53  ? -71.062 15.216  -70.959  1.00 26.44  ? 65   ALA B N   1 
ATOM   716  C CA  . ALA C 2 53  ? -72.314 15.411  -70.233  1.00 21.70  ? 65   ALA B CA  1 
ATOM   717  C C   . ALA C 2 53  ? -72.058 15.666  -68.751  1.00 30.34  ? 65   ALA B C   1 
ATOM   718  O O   . ALA C 2 53  ? -72.624 16.597  -68.164  1.00 38.07  ? 65   ALA B O   1 
ATOM   719  C CB  . ALA C 2 53  ? -73.227 14.201  -70.428  1.00 20.58  ? 65   ALA B CB  1 
ATOM   720  N N   . LEU C 2 54  ? -71.196 14.854  -68.131  1.00 24.50  ? 66   LEU B N   1 
ATOM   721  C CA  . LEU C 2 54  ? -70.888 15.050  -66.716  1.00 17.52  ? 66   LEU B CA  1 
ATOM   722  C C   . LEU C 2 54  ? -70.185 16.380  -66.484  1.00 17.67  ? 66   LEU B C   1 
ATOM   723  O O   . LEU C 2 54  ? -70.422 17.048  -65.470  1.00 24.21  ? 66   LEU B O   1 
ATOM   724  C CB  . LEU C 2 54  ? -70.028 13.899  -66.197  1.00 21.01  ? 66   LEU B CB  1 
ATOM   725  C CG  . LEU C 2 54  ? -70.432 12.497  -66.647  1.00 29.88  ? 66   LEU B CG  1 
ATOM   726  C CD1 . LEU C 2 54  ? -69.257 11.546  -66.503  1.00 21.15  ? 66   LEU B CD1 1 
ATOM   727  C CD2 . LEU C 2 54  ? -71.636 12.002  -65.852  1.00 30.47  ? 66   LEU B CD2 1 
ATOM   728  N N   . LEU C 2 55  ? -69.308 16.776  -67.408  1.00 19.14  ? 67   LEU B N   1 
ATOM   729  C CA  . LEU C 2 55  ? -68.662 18.078  -67.292  1.00 19.02  ? 67   LEU B CA  1 
ATOM   730  C C   . LEU C 2 55  ? -69.690 19.200  -67.357  1.00 31.48  ? 67   LEU B C   1 
ATOM   731  O O   . LEU C 2 55  ? -69.578 20.200  -66.637  1.00 35.14  ? 67   LEU B O   1 
ATOM   732  C CB  . LEU C 2 55  ? -67.612 18.239  -68.389  1.00 18.38  ? 67   LEU B CB  1 
ATOM   733  C CG  . LEU C 2 55  ? -66.197 17.800  -68.008  1.00 15.91  ? 67   LEU B CG  1 
ATOM   734  C CD1 . LEU C 2 55  ? -65.323 17.662  -69.247  1.00 14.49  ? 67   LEU B CD1 1 
ATOM   735  C CD2 . LEU C 2 55  ? -65.584 18.771  -67.011  1.00 16.55  ? 67   LEU B CD2 1 
ATOM   736  N N   . GLN C 2 56  ? -70.708 19.044  -68.207  1.00 24.51  ? 68   GLN B N   1 
ATOM   737  C CA  . GLN C 2 56  ? -71.796 20.015  -68.241  1.00 23.11  ? 68   GLN B CA  1 
ATOM   738  C C   . GLN C 2 56  ? -72.530 20.059  -66.907  1.00 34.42  ? 68   GLN B C   1 
ATOM   739  O O   . GLN C 2 56  ? -72.813 21.140  -66.377  1.00 37.44  ? 68   GLN B O   1 
ATOM   740  C CB  . GLN C 2 56  ? -72.760 19.680  -69.376  1.00 30.88  ? 68   GLN B CB  1 
ATOM   741  C CG  . GLN C 2 56  ? -73.505 20.886  -69.909  1.00 42.20  ? 68   GLN B CG  1 
ATOM   742  C CD  . GLN C 2 56  ? -74.392 20.541  -71.081  1.00 38.70  ? 68   GLN B CD  1 
ATOM   743  O OE1 . GLN C 2 56  ? -74.956 19.446  -71.148  1.00 35.41  ? 68   GLN B OE1 1 
ATOM   744  N NE2 . GLN C 2 56  ? -74.517 21.472  -72.019  1.00 42.37  ? 68   GLN B NE2 1 
ATOM   745  N N   . GLU C 2 57  ? -72.845 18.884  -66.349  1.00 26.88  ? 69   GLU B N   1 
ATOM   746  C CA  . GLU C 2 57  ? -73.509 18.819  -65.049  1.00 22.12  ? 69   GLU B CA  1 
ATOM   747  C C   . GLU C 2 57  ? -72.758 19.624  -63.999  1.00 27.10  ? 69   GLU B C   1 
ATOM   748  O O   . GLU C 2 57  ? -73.371 20.263  -63.135  1.00 24.11  ? 69   GLU B O   1 
ATOM   749  C CB  . GLU C 2 57  ? -73.635 17.363  -64.598  1.00 24.57  ? 69   GLU B CB  1 
ATOM   750  C CG  . GLU C 2 57  ? -74.910 16.680  -65.031  1.00 29.22  ? 69   GLU B CG  1 
ATOM   751  C CD  . GLU C 2 57  ? -76.144 17.466  -64.645  1.00 46.86  ? 69   GLU B CD  1 
ATOM   752  O OE1 . GLU C 2 57  ? -76.195 17.974  -63.503  1.00 45.75  ? 69   GLU B OE1 1 
ATOM   753  O OE2 . GLU C 2 57  ? -77.062 17.578  -65.488  1.00 38.71  ? 69   GLU B OE2 1 
ATOM   754  N N   . ILE C 2 58  ? -71.425 19.605  -64.064  1.00 26.17  ? 70   ILE B N   1 
ATOM   755  C CA  . ILE C 2 58  ? -70.612 20.330  -63.094  1.00 28.57  ? 70   ILE B CA  1 
ATOM   756  C C   . ILE C 2 58  ? -70.729 21.830  -63.318  1.00 35.42  ? 70   ILE B C   1 
ATOM   757  O O   . ILE C 2 58  ? -71.058 22.590  -62.400  1.00 41.25  ? 70   ILE B O   1 
ATOM   758  C CB  . ILE C 2 58  ? -69.149 19.862  -63.178  1.00 25.05  ? 70   ILE B CB  1 
ATOM   759  C CG1 . ILE C 2 58  ? -69.030 18.422  -62.683  1.00 20.42  ? 70   ILE B CG1 1 
ATOM   760  C CG2 . ILE C 2 58  ? -68.230 20.794  -62.393  1.00 23.08  ? 70   ILE B CG2 1 
ATOM   761  C CD1 . ILE C 2 58  ? -67.931 17.643  -63.359  1.00 24.32  ? 70   ILE B CD1 1 
ATOM   762  N N   . VAL C 2 59  ? -70.464 22.279  -64.546  1.00 32.30  ? 71   VAL B N   1 
ATOM   763  C CA  . VAL C 2 59  ? -70.506 23.709  -64.833  1.00 40.30  ? 71   VAL B CA  1 
ATOM   764  C C   . VAL C 2 59  ? -71.916 24.258  -64.657  1.00 35.08  ? 71   VAL B C   1 
ATOM   765  O O   . VAL C 2 59  ? -72.093 25.427  -64.294  1.00 36.62  ? 71   VAL B O   1 
ATOM   766  C CB  . VAL C 2 59  ? -69.955 23.976  -66.248  1.00 37.53  ? 71   VAL B CB  1 
ATOM   767  C CG1 . VAL C 2 59  ? -69.755 25.466  -66.473  1.00 47.73  ? 71   VAL B CG1 1 
ATOM   768  C CG2 . VAL C 2 59  ? -68.643 23.231  -66.444  1.00 21.87  ? 71   VAL B CG2 1 
ATOM   769  N N   . ASN C 2 60  ? -72.938 23.425  -64.871  1.00 30.46  ? 72   ASN B N   1 
ATOM   770  C CA  . ASN C 2 60  ? -74.317 23.899  -64.807  1.00 32.16  ? 72   ASN B CA  1 
ATOM   771  C C   . ASN C 2 60  ? -74.697 24.434  -63.434  1.00 37.98  ? 72   ASN B C   1 
ATOM   772  O O   . ASN C 2 60  ? -75.660 25.202  -63.329  1.00 45.39  ? 72   ASN B O   1 
ATOM   773  C CB  . ASN C 2 60  ? -75.275 22.778  -65.206  1.00 23.54  ? 72   ASN B CB  1 
ATOM   774  C CG  . ASN C 2 60  ? -75.629 22.822  -66.672  1.00 39.17  ? 72   ASN B CG  1 
ATOM   775  O OD1 . ASN C 2 60  ? -75.359 23.811  -67.356  1.00 42.92  ? 72   ASN B OD1 1 
ATOM   776  N ND2 . ASN C 2 60  ? -76.232 21.746  -67.170  1.00 36.46  ? 72   ASN B ND2 1 
ATOM   777  N N   . ILE C 2 61  ? -73.974 24.049  -62.379  1.00 30.90  ? 73   ILE B N   1 
ATOM   778  C CA  . ILE C 2 61  ? -74.270 24.534  -61.037  1.00 27.46  ? 73   ILE B CA  1 
ATOM   779  C C   . ILE C 2 61  ? -73.344 25.665  -60.619  1.00 32.78  ? 73   ILE B C   1 
ATOM   780  O O   . ILE C 2 61  ? -73.517 26.224  -59.527  1.00 46.09  ? 73   ILE B O   1 
ATOM   781  C CB  . ILE C 2 61  ? -74.244 23.371  -60.017  1.00 24.97  ? 73   ILE B CB  1 
ATOM   782  C CG1 . ILE C 2 61  ? -72.819 22.961  -59.628  1.00 31.33  ? 73   ILE B CG1 1 
ATOM   783  C CG2 . ILE C 2 61  ? -75.002 22.167  -60.561  1.00 37.02  ? 73   ILE B CG2 1 
ATOM   784  C CD1 . ILE C 2 61  ? -72.262 23.675  -58.404  1.00 33.82  ? 73   ILE B CD1 1 
ATOM   785  N N   . TYR C 2 62  ? -72.375 26.027  -61.461  1.00 30.61  ? 74   TYR B N   1 
ATOM   786  C CA  . TYR C 2 62  ? -71.496 27.159  -61.171  1.00 32.91  ? 74   TYR B CA  1 
ATOM   787  C C   . TYR C 2 62  ? -72.242 28.447  -60.836  1.00 42.49  ? 74   TYR B C   1 
ATOM   788  O O   . TYR C 2 62  ? -71.787 29.165  -59.928  1.00 45.18  ? 74   TYR B O   1 
ATOM   789  C CB  . TYR C 2 62  ? -70.549 27.383  -62.360  1.00 36.84  ? 74   TYR B CB  1 
ATOM   790  C CG  . TYR C 2 62  ? -69.315 26.507  -62.365  1.00 36.08  ? 74   TYR B CG  1 
ATOM   791  C CD1 . TYR C 2 62  ? -69.294 25.296  -61.687  1.00 48.22  ? 74   TYR B CD1 1 
ATOM   792  C CD2 . TYR C 2 62  ? -68.192 26.864  -63.098  1.00 35.10  ? 74   TYR B CD2 1 
ATOM   793  C CE1 . TYR C 2 62  ? -68.168 24.489  -61.700  1.00 52.80  ? 74   TYR B CE1 1 
ATOM   794  C CE2 . TYR C 2 62  ? -67.064 26.067  -63.119  1.00 41.31  ? 74   TYR B CE2 1 
ATOM   795  C CZ  . TYR C 2 62  ? -67.057 24.877  -62.422  1.00 44.13  ? 74   TYR B CZ  1 
ATOM   796  O OH  . TYR C 2 62  ? -65.938 24.072  -62.446  1.00 31.73  ? 74   TYR B OH  1 
ATOM   797  N N   . PRO C 2 63  ? -73.346 28.811  -61.504  1.00 46.51  ? 75   PRO B N   1 
ATOM   798  C CA  . PRO C 2 63  ? -74.089 30.008  -61.072  1.00 43.33  ? 75   PRO B CA  1 
ATOM   799  C C   . PRO C 2 63  ? -74.582 29.941  -59.638  1.00 46.83  ? 75   PRO B C   1 
ATOM   800  O O   . PRO C 2 63  ? -74.633 30.977  -58.964  1.00 55.09  ? 75   PRO B O   1 
ATOM   801  C CB  . PRO C 2 63  ? -75.257 30.067  -62.066  1.00 39.43  ? 75   PRO B CB  1 
ATOM   802  C CG  . PRO C 2 63  ? -74.730 29.406  -63.287  1.00 33.37  ? 75   PRO B CG  1 
ATOM   803  C CD  . PRO C 2 63  ? -73.873 28.285  -62.781  1.00 34.30  ? 75   PRO B CD  1 
ATOM   804  N N   . SER C 2 64  ? -74.945 28.757  -59.148  1.00 46.42  ? 76   SER B N   1 
ATOM   805  C CA  . SER C 2 64  ? -75.432 28.608  -57.783  1.00 39.89  ? 76   SER B CA  1 
ATOM   806  C C   . SER C 2 64  ? -74.321 28.684  -56.739  1.00 36.36  ? 76   SER B C   1 
ATOM   807  O O   . SER C 2 64  ? -74.607 28.535  -55.546  1.00 34.51  ? 76   SER B O   1 
ATOM   808  C CB  . SER C 2 64  ? -76.192 27.285  -57.640  1.00 33.75  ? 76   SER B CB  1 
ATOM   809  O OG  . SER C 2 64  ? -77.282 27.217  -58.548  1.00 28.30  ? 76   SER B OG  1 
ATOM   810  N N   . ILE C 2 65  ? -73.075 28.918  -57.147  1.00 36.18  ? 77   ILE B N   1 
ATOM   811  C CA  . ILE C 2 65  ? -71.963 29.005  -56.203  1.00 38.42  ? 77   ILE B CA  1 
ATOM   812  C C   . ILE C 2 65  ? -71.824 30.411  -55.634  1.00 49.13  ? 77   ILE B C   1 
ATOM   813  O O   . ILE C 2 65  ? -71.750 30.599  -54.417  1.00 57.24  ? 77   ILE B O   1 
ATOM   814  C CB  . ILE C 2 65  ? -70.654 28.548  -56.878  1.00 38.11  ? 77   ILE B CB  1 
ATOM   815  C CG1 . ILE C 2 65  ? -70.680 27.044  -57.143  1.00 37.06  ? 77   ILE B CG1 1 
ATOM   816  C CG2 . ILE C 2 65  ? -69.458 28.898  -56.007  1.00 33.37  ? 77   ILE B CG2 1 
ATOM   817  C CD1 . ILE C 2 65  ? -69.380 26.512  -57.705  1.00 35.57  ? 77   ILE B CD1 1 
ATOM   818  N N   . ASN C 2 66  ? -71.773 31.419  -56.497  1.00 60.78  ? 78   ASN B N   1 
ATOM   819  C CA  . ASN C 2 66  ? -71.614 32.807  -56.069  1.00 49.73  ? 78   ASN B CA  1 
ATOM   820  C C   . ASN C 2 66  ? -72.614 33.682  -56.814  1.00 57.10  ? 78   ASN B C   1 
ATOM   821  O O   . ASN C 2 66  ? -72.433 33.926  -58.025  1.00 65.80  ? 78   ASN B O   1 
ATOM   822  C CB  . ASN C 2 66  ? -70.186 33.288  -56.308  1.00 42.15  ? 78   ASN B CB  1 
ATOM   823  C CG  . ASN C 2 66  ? -69.810 34.451  -55.418  1.00 61.30  ? 78   ASN B CG  1 
ATOM   824  O OD1 . ASN C 2 66  ? -70.678 35.144  -54.883  1.00 59.40  ? 78   ASN B OD1 1 
ATOM   825  N ND2 . ASN C 2 66  ? -68.510 34.674  -55.251  1.00 68.30  ? 78   ASN B ND2 1 
ATOM   826  N N   . PRO C 2 67  ? -73.673 34.173  -56.152  1.00 46.89  ? 79   PRO B N   1 
ATOM   827  C CA  . PRO C 2 67  ? -74.060 33.942  -54.749  1.00 50.80  ? 79   PRO B CA  1 
ATOM   828  C C   . PRO C 2 67  ? -74.514 32.507  -54.490  1.00 44.29  ? 79   PRO B C   1 
ATOM   829  O O   . PRO C 2 67  ? -75.046 31.846  -55.379  1.00 48.09  ? 79   PRO B O   1 
ATOM   830  C CB  . PRO C 2 67  ? -75.211 34.941  -54.537  1.00 61.01  ? 79   PRO B CB  1 
ATOM   831  C CG  . PRO C 2 67  ? -74.996 36.002  -55.577  1.00 60.67  ? 79   PRO B CG  1 
ATOM   832  C CD  . PRO C 2 67  ? -74.481 35.242  -56.763  1.00 50.67  ? 79   PRO B CD  1 
ATOM   833  N N   . PRO C 2 68  ? -74.302 32.005  -53.270  1.00 37.13  ? 80   PRO B N   1 
ATOM   834  C CA  . PRO C 2 68  ? -74.634 30.603  -52.974  1.00 38.21  ? 80   PRO B CA  1 
ATOM   835  C C   . PRO C 2 68  ? -76.130 30.335  -52.942  1.00 34.96  ? 80   PRO B C   1 
ATOM   836  O O   . PRO C 2 68  ? -76.815 30.708  -51.985  1.00 40.36  ? 80   PRO B O   1 
ATOM   837  C CB  . PRO C 2 68  ? -73.996 30.374  -51.597  1.00 30.42  ? 80   PRO B CB  1 
ATOM   838  C CG  . PRO C 2 68  ? -73.854 31.735  -51.006  1.00 23.10  ? 80   PRO B CG  1 
ATOM   839  C CD  . PRO C 2 68  ? -73.618 32.669  -52.149  1.00 41.00  ? 80   PRO B CD  1 
ATOM   840  N N   . THR C 2 69  ? -76.640 29.686  -53.987  1.00 43.83  ? 81   THR B N   1 
ATOM   841  C CA  . THR C 2 69  ? -78.043 29.302  -54.104  1.00 38.86  ? 81   THR B CA  1 
ATOM   842  C C   . THR C 2 69  ? -78.166 27.823  -54.446  1.00 40.78  ? 81   THR B C   1 
ATOM   843  O O   . THR C 2 69  ? -78.996 27.423  -55.267  1.00 48.85  ? 81   THR B O   1 
ATOM   844  C CB  . THR C 2 69  ? -78.765 30.144  -55.157  1.00 51.36  ? 81   THR B CB  1 
ATOM   845  O OG1 . THR C 2 69  ? -78.617 29.531  -56.446  1.00 45.52  ? 81   THR B OG1 1 
ATOM   846  C CG2 . THR C 2 69  ? -78.209 31.562  -55.210  1.00 48.32  ? 81   THR B CG2 1 
ATOM   847  N N   . LEU C 2 70  ? -77.340 26.985  -53.826  1.00 36.07  ? 82   LEU B N   1 
ATOM   848  C CA  . LEU C 2 70  ? -77.288 25.572  -54.184  1.00 36.87  ? 82   LEU B CA  1 
ATOM   849  C C   . LEU C 2 70  ? -78.386 24.809  -53.455  1.00 30.41  ? 82   LEU B C   1 
ATOM   850  O O   . LEU C 2 70  ? -78.373 24.716  -52.223  1.00 30.69  ? 82   LEU B O   1 
ATOM   851  C CB  . LEU C 2 70  ? -75.915 24.993  -53.852  1.00 32.96  ? 82   LEU B CB  1 
ATOM   852  C CG  . LEU C 2 70  ? -75.619 23.545  -54.237  1.00 30.96  ? 82   LEU B CG  1 
ATOM   853  C CD1 . LEU C 2 70  ? -75.786 23.336  -55.730  1.00 34.73  ? 82   LEU B CD1 1 
ATOM   854  C CD2 . LEU C 2 70  ? -74.217 23.163  -53.789  1.00 35.52  ? 82   LEU B CD2 1 
ATOM   855  N N   . THR C 2 71  ? -79.328 24.257  -54.216  1.00 24.14  ? 83   THR B N   1 
ATOM   856  C CA  . THR C 2 71  ? -80.415 23.483  -53.639  1.00 30.75  ? 83   THR B CA  1 
ATOM   857  C C   . THR C 2 71  ? -79.947 22.070  -53.294  1.00 36.10  ? 83   THR B C   1 
ATOM   858  O O   . THR C 2 71  ? -78.827 21.658  -53.606  1.00 44.39  ? 83   THR B O   1 
ATOM   859  C CB  . THR C 2 71  ? -81.603 23.416  -54.599  1.00 35.19  ? 83   THR B CB  1 
ATOM   860  O OG1 . THR C 2 71  ? -81.376 22.387  -55.572  1.00 42.20  ? 83   THR B OG1 1 
ATOM   861  C CG2 . THR C 2 71  ? -81.794 24.748  -55.308  1.00 50.81  ? 83   THR B CG2 1 
ATOM   862  N N   . ALA C 2 72  ? -80.832 21.319  -52.634  1.00 40.89  ? 84   ALA B N   1 
ATOM   863  C CA  . ALA C 2 72  ? -80.532 19.924  -52.330  1.00 36.33  ? 84   ALA B CA  1 
ATOM   864  C C   . ALA C 2 72  ? -80.645 19.057  -53.575  1.00 42.07  ? 84   ALA B C   1 
ATOM   865  O O   . ALA C 2 72  ? -79.863 18.116  -53.758  1.00 46.18  ? 84   ALA B O   1 
ATOM   866  C CB  . ALA C 2 72  ? -81.462 19.410  -51.234  1.00 39.65  ? 84   ALA B CB  1 
ATOM   867  N N   . HIS C 2 73  ? -81.619 19.355  -54.439  1.00 38.70  ? 85   HIS B N   1 
ATOM   868  C CA  . HIS C 2 73  ? -81.741 18.620  -55.692  1.00 50.24  ? 85   HIS B CA  1 
ATOM   869  C C   . HIS C 2 73  ? -80.540 18.873  -56.592  1.00 46.46  ? 85   HIS B C   1 
ATOM   870  O O   . HIS C 2 73  ? -80.014 17.940  -57.212  1.00 48.01  ? 85   HIS B O   1 
ATOM   871  C CB  . HIS C 2 73  ? -83.035 19.003  -56.406  1.00 46.39  ? 85   HIS B CB  1 
ATOM   872  C CG  . HIS C 2 73  ? -83.559 17.936  -57.314  1.00 53.92  ? 85   HIS B CG  1 
ATOM   873  N ND1 . HIS C 2 73  ? -82.788 16.874  -57.734  1.00 60.67  ? 85   HIS B ND1 1 
ATOM   874  C CD2 . HIS C 2 73  ? -84.776 17.766  -57.883  1.00 77.66  ? 85   HIS B CD2 1 
ATOM   875  C CE1 . HIS C 2 73  ? -83.507 16.094  -58.521  1.00 71.94  ? 85   HIS B CE1 1 
ATOM   876  N NE2 . HIS C 2 73  ? -84.717 16.613  -58.628  1.00 90.55  ? 85   HIS B NE2 1 
ATOM   877  N N   . GLN C 2 74  ? -80.096 20.128  -56.677  1.00 41.43  ? 86   GLN B N   1 
ATOM   878  C CA  . GLN C 2 74  ? -78.887 20.439  -57.431  1.00 45.28  ? 86   GLN B CA  1 
ATOM   879  C C   . GLN C 2 74  ? -77.697 19.656  -56.892  1.00 39.28  ? 86   GLN B C   1 
ATOM   880  O O   . GLN C 2 74  ? -76.925 19.067  -57.658  1.00 44.49  ? 86   GLN B O   1 
ATOM   881  C CB  . GLN C 2 74  ? -78.604 21.940  -57.373  1.00 43.83  ? 86   GLN B CB  1 
ATOM   882  C CG  . GLN C 2 74  ? -79.354 22.784  -58.386  1.00 41.12  ? 86   GLN B CG  1 
ATOM   883  C CD  . GLN C 2 74  ? -78.982 24.254  -58.288  1.00 38.63  ? 86   GLN B CD  1 
ATOM   884  O OE1 . GLN C 2 74  ? -79.202 24.894  -57.259  1.00 36.72  ? 86   GLN B OE1 1 
ATOM   885  N NE2 . GLN C 2 74  ? -78.404 24.793  -59.358  1.00 43.89  ? 86   GLN B NE2 1 
ATOM   886  N N   . SER C 2 75  ? -77.545 19.629  -55.566  1.00 34.20  ? 87   SER B N   1 
ATOM   887  C CA  . SER C 2 75  ? -76.368 19.016  -54.959  1.00 37.47  ? 87   SER B CA  1 
ATOM   888  C C   . SER C 2 75  ? -76.345 17.511  -55.189  1.00 42.57  ? 87   SER B C   1 
ATOM   889  O O   . SER C 2 75  ? -75.313 16.946  -55.569  1.00 49.41  ? 87   SER B O   1 
ATOM   890  C CB  . SER C 2 75  ? -76.326 19.331  -53.465  1.00 36.73  ? 87   SER B CB  1 
ATOM   891  O OG  . SER C 2 75  ? -74.993 19.325  -52.986  1.00 37.41  ? 87   SER B OG  1 
ATOM   892  N N   . ASN C 2 76  ? -77.475 16.842  -54.958  1.00 35.01  ? 88   ASN B N   1 
ATOM   893  C CA  . ASN C 2 76  ? -77.515 15.400  -55.161  1.00 37.03  ? 88   ASN B CA  1 
ATOM   894  C C   . ASN C 2 76  ? -77.333 15.045  -56.630  1.00 52.92  ? 88   ASN B C   1 
ATOM   895  O O   . ASN C 2 76  ? -76.684 14.044  -56.957  1.00 60.24  ? 88   ASN B O   1 
ATOM   896  C CB  . ASN C 2 76  ? -78.825 14.833  -54.628  1.00 33.33  ? 88   ASN B CB  1 
ATOM   897  C CG  . ASN C 2 76  ? -78.618 13.571  -53.826  1.00 55.91  ? 88   ASN B CG  1 
ATOM   898  O OD1 . ASN C 2 76  ? -77.541 12.972  -53.859  1.00 49.71  ? 88   ASN B OD1 1 
ATOM   899  N ND2 . ASN C 2 76  ? -79.644 13.164  -53.089  1.00 72.53  ? 88   ASN B ND2 1 
ATOM   900  N N   . ARG C 2 77  ? -77.888 15.861  -57.529  1.00 53.37  ? 89   ARG B N   1 
ATOM   901  C CA  . ARG C 2 77  ? -77.782 15.571  -58.955  1.00 42.97  ? 89   ARG B CA  1 
ATOM   902  C C   . ARG C 2 77  ? -76.344 15.703  -59.436  1.00 40.33  ? 89   ARG B C   1 
ATOM   903  O O   . ARG C 2 77  ? -75.814 14.800  -60.093  1.00 48.11  ? 89   ARG B O   1 
ATOM   904  C CB  . ARG C 2 77  ? -78.709 16.495  -59.749  1.00 42.64  ? 89   ARG B CB  1 
ATOM   905  C CG  . ARG C 2 77  ? -78.165 16.921  -61.106  1.00 48.67  ? 89   ARG B CG  1 
ATOM   906  C CD  . ARG C 2 77  ? -79.189 17.724  -61.895  1.00 63.74  ? 89   ARG B CD  1 
ATOM   907  N NE  . ARG C 2 77  ? -80.002 16.881  -62.764  1.00 53.81  ? 89   ARG B NE  1 
ATOM   908  C CZ  . ARG C 2 77  ? -80.020 16.971  -64.087  1.00 55.61  ? 89   ARG B CZ  1 
ATOM   909  N NH1 . ARG C 2 77  ? -79.284 17.862  -64.730  1.00 50.04  ? 89   ARG B NH1 1 
ATOM   910  N NH2 . ARG C 2 77  ? -80.798 16.147  -64.783  1.00 61.48  ? 89   ARG B NH2 1 
ATOM   911  N N   . VAL C 2 78  ? -75.688 16.820  -59.111  1.00 42.22  ? 90   VAL B N   1 
ATOM   912  C CA  . VAL C 2 78  ? -74.341 17.046  -59.613  1.00 36.97  ? 90   VAL B CA  1 
ATOM   913  C C   . VAL C 2 78  ? -73.334 16.125  -58.935  1.00 40.77  ? 90   VAL B C   1 
ATOM   914  O O   . VAL C 2 78  ? -72.288 15.820  -59.519  1.00 43.62  ? 90   VAL B O   1 
ATOM   915  C CB  . VAL C 2 78  ? -73.954 18.530  -59.453  1.00 22.72  ? 90   VAL B CB  1 
ATOM   916  C CG1 . VAL C 2 78  ? -73.639 18.854  -58.007  1.00 37.26  ? 90   VAL B CG1 1 
ATOM   917  C CG2 . VAL C 2 78  ? -72.780 18.876  -60.351  1.00 24.68  ? 90   VAL B CG2 1 
ATOM   918  N N   . CYS C 2 79  ? -73.631 15.649  -57.725  1.00 41.29  ? 91   CYS B N   1 
ATOM   919  C CA  . CYS C 2 79  ? -72.728 14.714  -57.065  1.00 40.50  ? 91   CYS B CA  1 
ATOM   920  C C   . CYS C 2 79  ? -72.848 13.310  -57.638  1.00 45.80  ? 91   CYS B C   1 
ATOM   921  O O   . CYS C 2 79  ? -71.861 12.565  -57.649  1.00 41.70  ? 91   CYS B O   1 
ATOM   922  C CB  . CYS C 2 79  ? -72.998 14.689  -55.565  1.00 36.54  ? 91   CYS B CB  1 
ATOM   923  S SG  . CYS C 2 79  ? -72.150 15.987  -54.641  1.00 51.54  ? 91   CYS B SG  1 
ATOM   924  N N   . ASN C 2 80  ? -74.039 12.932  -58.108  1.00 46.19  ? 92   ASN B N   1 
ATOM   925  C CA  . ASN C 2 80  ? -74.191 11.644  -58.774  1.00 40.11  ? 92   ASN B CA  1 
ATOM   926  C C   . ASN C 2 80  ? -73.343 11.569  -60.035  1.00 42.40  ? 92   ASN B C   1 
ATOM   927  O O   . ASN C 2 80  ? -72.846 10.493  -60.386  1.00 48.49  ? 92   ASN B O   1 
ATOM   928  C CB  . ASN C 2 80  ? -75.661 11.392  -59.100  1.00 31.79  ? 92   ASN B CB  1 
ATOM   929  C CG  . ASN C 2 80  ? -76.364 10.598  -58.023  1.00 50.68  ? 92   ASN B CG  1 
ATOM   930  O OD1 . ASN C 2 80  ? -75.834 10.412  -56.924  1.00 58.99  ? 92   ASN B OD1 1 
ATOM   931  N ND2 . ASN C 2 80  ? -77.564 10.119  -58.332  1.00 57.61  ? 92   ASN B ND2 1 
ATOM   932  N N   . ALA C 2 81  ? -73.170 12.696  -60.730  1.00 45.11  ? 93   ALA B N   1 
ATOM   933  C CA  . ALA C 2 81  ? -72.227 12.736  -61.842  1.00 34.96  ? 93   ALA B CA  1 
ATOM   934  C C   . ALA C 2 81  ? -70.791 12.736  -61.334  1.00 30.37  ? 93   ALA B C   1 
ATOM   935  O O   . ALA C 2 81  ? -69.914 12.102  -61.933  1.00 35.30  ? 93   ALA B O   1 
ATOM   936  C CB  . ALA C 2 81  ? -72.490 13.960  -62.718  1.00 34.24  ? 93   ALA B CB  1 
ATOM   937  N N   . LEU C 2 82  ? -70.533 13.445  -60.232  1.00 23.74  ? 94   LEU B N   1 
ATOM   938  C CA  . LEU C 2 82  ? -69.218 13.380  -59.605  1.00 23.65  ? 94   LEU B CA  1 
ATOM   939  C C   . LEU C 2 82  ? -68.884 11.960  -59.175  1.00 30.51  ? 94   LEU B C   1 
ATOM   940  O O   . LEU C 2 82  ? -67.719 11.548  -59.237  1.00 29.42  ? 94   LEU B O   1 
ATOM   941  C CB  . LEU C 2 82  ? -69.153 14.325  -58.407  1.00 29.10  ? 94   LEU B CB  1 
ATOM   942  C CG  . LEU C 2 82  ? -68.420 15.651  -58.611  1.00 9.50   ? 94   LEU B CG  1 
ATOM   943  C CD1 . LEU C 2 82  ? -69.098 16.459  -59.691  1.00 26.27  ? 94   LEU B CD1 1 
ATOM   944  C CD2 . LEU C 2 82  ? -68.359 16.444  -57.319  1.00 24.12  ? 94   LEU B CD2 1 
ATOM   945  N N   . ALA C 2 83  ? -69.890 11.199  -58.737  1.00 40.03  ? 95   ALA B N   1 
ATOM   946  C CA  . ALA C 2 83  ? -69.664 9.797   -58.403  1.00 50.18  ? 95   ALA B CA  1 
ATOM   947  C C   . ALA C 2 83  ? -69.211 9.010   -59.626  1.00 38.53  ? 95   ALA B C   1 
ATOM   948  O O   . ALA C 2 83  ? -68.270 8.211   -59.545  1.00 51.70  ? 95   ALA B O   1 
ATOM   949  C CB  . ALA C 2 83  ? -70.931 9.185   -57.807  1.00 56.21  ? 95   ALA B CB  1 
ATOM   950  N N   . LEU C 2 84  ? -69.864 9.227   -60.771  1.00 25.40  ? 96   LEU B N   1 
ATOM   951  C CA  . LEU C 2 84  ? -69.453 8.543   -61.992  1.00 36.92  ? 96   LEU B CA  1 
ATOM   952  C C   . LEU C 2 84  ? -68.070 8.989   -62.445  1.00 38.87  ? 96   LEU B C   1 
ATOM   953  O O   . LEU C 2 84  ? -67.309 8.182   -62.993  1.00 38.43  ? 96   LEU B O   1 
ATOM   954  C CB  . LEU C 2 84  ? -70.473 8.779   -63.106  1.00 25.69  ? 96   LEU B CB  1 
ATOM   955  C CG  . LEU C 2 84  ? -71.871 8.198   -62.887  1.00 21.21  ? 96   LEU B CG  1 
ATOM   956  C CD1 . LEU C 2 84  ? -72.658 8.197   -64.189  1.00 20.20  ? 96   LEU B CD1 1 
ATOM   957  C CD2 . LEU C 2 84  ? -71.785 6.796   -62.310  1.00 23.42  ? 96   LEU B CD2 1 
ATOM   958  N N   . LEU C 2 85  ? -67.728 10.262  -62.232  1.00 38.02  ? 97   LEU B N   1 
ATOM   959  C CA  . LEU C 2 85  ? -66.388 10.724  -62.572  1.00 38.54  ? 97   LEU B CA  1 
ATOM   960  C C   . LEU C 2 85  ? -65.342 10.114  -61.652  1.00 40.62  ? 97   LEU B C   1 
ATOM   961  O O   . LEU C 2 85  ? -64.199 9.895   -62.071  1.00 48.82  ? 97   LEU B O   1 
ATOM   962  C CB  . LEU C 2 85  ? -66.317 12.248  -62.511  1.00 29.92  ? 97   LEU B CB  1 
ATOM   963  C CG  . LEU C 2 85  ? -66.644 12.977  -63.814  1.00 25.43  ? 97   LEU B CG  1 
ATOM   964  C CD1 . LEU C 2 85  ? -66.287 14.448  -63.693  1.00 20.09  ? 97   LEU B CD1 1 
ATOM   965  C CD2 . LEU C 2 85  ? -65.923 12.336  -64.987  1.00 27.68  ? 97   LEU B CD2 1 
ATOM   966  N N   . GLN C 2 86  ? -65.708 9.842   -60.400  1.00 41.64  ? 98   GLN B N   1 
ATOM   967  C CA  . GLN C 2 86  ? -64.794 9.139   -59.510  1.00 53.13  ? 98   GLN B CA  1 
ATOM   968  C C   . GLN C 2 86  ? -64.549 7.715   -59.995  1.00 49.05  ? 98   GLN B C   1 
ATOM   969  O O   . GLN C 2 86  ? -63.435 7.193   -59.869  1.00 53.28  ? 98   GLN B O   1 
ATOM   970  C CB  . GLN C 2 86  ? -65.344 9.142   -58.086  1.00 38.67  ? 98   GLN B CB  1 
ATOM   971  C CG  . GLN C 2 86  ? -64.404 8.539   -57.070  1.00 43.36  ? 98   GLN B CG  1 
ATOM   972  C CD  . GLN C 2 86  ? -64.779 7.115   -56.720  1.00 63.08  ? 98   GLN B CD  1 
ATOM   973  O OE1 . GLN C 2 86  ? -65.855 6.636   -57.086  1.00 56.47  ? 98   GLN B OE1 1 
ATOM   974  N NE2 . GLN C 2 86  ? -63.895 6.428   -56.005  1.00 71.31  ? 98   GLN B NE2 1 
ATOM   975  N N   . CYS C 2 87  ? -65.577 7.073   -60.556  1.00 42.46  ? 99   CYS B N   1 
ATOM   976  C CA  . CYS C 2 87  ? -65.392 5.745   -61.129  1.00 35.14  ? 99   CYS B CA  1 
ATOM   977  C C   . CYS C 2 87  ? -64.407 5.785   -62.287  1.00 40.37  ? 99   CYS B C   1 
ATOM   978  O O   . CYS C 2 87  ? -63.549 4.902   -62.414  1.00 48.41  ? 99   CYS B O   1 
ATOM   979  C CB  . CYS C 2 87  ? -66.733 5.177   -61.590  1.00 36.47  ? 99   CYS B CB  1 
ATOM   980  S SG  . CYS C 2 87  ? -66.586 3.848   -62.802  1.00 66.82  ? 99   CYS B SG  1 
ATOM   981  N N   . VAL C 2 88  ? -64.515 6.806   -63.141  1.00 39.65  ? 100  VAL B N   1 
ATOM   982  C CA  . VAL C 2 88  ? -63.559 6.974   -64.231  1.00 26.32  ? 100  VAL B CA  1 
ATOM   983  C C   . VAL C 2 88  ? -62.162 7.220   -63.678  1.00 39.10  ? 100  VAL B C   1 
ATOM   984  O O   . VAL C 2 88  ? -61.176 6.636   -64.148  1.00 39.83  ? 100  VAL B O   1 
ATOM   985  C CB  . VAL C 2 88  ? -64.014 8.111   -65.163  1.00 17.59  ? 100  VAL B CB  1 
ATOM   986  C CG1 . VAL C 2 88  ? -62.874 8.556   -66.064  1.00 26.93  ? 100  VAL B CG1 1 
ATOM   987  C CG2 . VAL C 2 88  ? -65.204 7.663   -65.990  1.00 32.41  ? 100  VAL B CG2 1 
ATOM   988  N N   . ALA C 2 89  ? -62.058 8.071   -62.658  1.00 37.41  ? 101  ALA B N   1 
ATOM   989  C CA  . ALA C 2 89  ? -60.762 8.391   -62.080  1.00 34.43  ? 101  ALA B CA  1 
ATOM   990  C C   . ALA C 2 89  ? -60.167 7.229   -61.296  1.00 45.08  ? 101  ALA B C   1 
ATOM   991  O O   . ALA C 2 89  ? -58.954 7.211   -61.065  1.00 42.92  ? 101  ALA B O   1 
ATOM   992  C CB  . ALA C 2 89  ? -60.891 9.619   -61.181  1.00 35.24  ? 101  ALA B CB  1 
ATOM   993  N N   . SER C 2 90  ? -60.986 6.263   -60.879  1.00 52.08  ? 102  SER B N   1 
ATOM   994  C CA  . SER C 2 90  ? -60.470 5.143   -60.100  1.00 44.27  ? 102  SER B CA  1 
ATOM   995  C C   . SER C 2 90  ? -59.936 4.041   -61.005  1.00 41.28  ? 102  SER B C   1 
ATOM   996  O O   . SER C 2 90  ? -58.850 3.502   -60.765  1.00 55.10  ? 102  SER B O   1 
ATOM   997  C CB  . SER C 2 90  ? -61.560 4.595   -59.178  1.00 42.98  ? 102  SER B CB  1 
ATOM   998  O OG  . SER C 2 90  ? -61.493 5.192   -57.895  1.00 62.26  ? 102  SER B OG  1 
ATOM   999  N N   . HIS C 2 91  ? -60.685 3.700   -62.047  1.00 37.75  ? 103  HIS B N   1 
ATOM   1000 C CA  . HIS C 2 91  ? -60.304 2.604   -62.926  1.00 43.59  ? 103  HIS B CA  1 
ATOM   1001 C C   . HIS C 2 91  ? -58.955 2.892   -63.575  1.00 38.41  ? 103  HIS B C   1 
ATOM   1002 O O   . HIS C 2 91  ? -58.767 3.975   -64.147  1.00 48.69  ? 103  HIS B O   1 
ATOM   1003 C CB  . HIS C 2 91  ? -61.365 2.396   -64.000  1.00 32.20  ? 103  HIS B CB  1 
ATOM   1004 C CG  . HIS C 2 91  ? -61.312 1.054   -64.657  1.00 28.00  ? 103  HIS B CG  1 
ATOM   1005 N ND1 . HIS C 2 91  ? -60.203 0.603   -65.340  1.00 33.77  ? 103  HIS B ND1 1 
ATOM   1006 C CD2 . HIS C 2 91  ? -62.235 0.068   -64.745  1.00 42.19  ? 103  HIS B CD2 1 
ATOM   1007 C CE1 . HIS C 2 91  ? -60.443 -0.607  -65.814  1.00 45.32  ? 103  HIS B CE1 1 
ATOM   1008 N NE2 . HIS C 2 91  ? -61.670 -0.954  -65.469  1.00 50.64  ? 103  HIS B NE2 1 
ATOM   1009 N N   . PRO C 2 92  ? -57.999 1.964   -63.511  1.00 33.78  ? 104  PRO B N   1 
ATOM   1010 C CA  . PRO C 2 92  ? -56.693 2.232   -64.127  1.00 34.46  ? 104  PRO B CA  1 
ATOM   1011 C C   . PRO C 2 92  ? -56.771 2.440   -65.626  1.00 41.47  ? 104  PRO B C   1 
ATOM   1012 O O   . PRO C 2 92  ? -55.998 3.236   -66.160  1.00 53.79  ? 104  PRO B O   1 
ATOM   1013 C CB  . PRO C 2 92  ? -55.871 0.986   -63.765  1.00 50.55  ? 104  PRO B CB  1 
ATOM   1014 C CG  . PRO C 2 92  ? -56.886 -0.073  -63.485  1.00 50.25  ? 104  PRO B CG  1 
ATOM   1015 C CD  . PRO C 2 92  ? -58.049 0.642   -62.867  1.00 41.96  ? 104  PRO B CD  1 
ATOM   1016 N N   . GLU C 2 93  ? -57.699 1.780   -66.321  1.00 38.96  ? 105  GLU B N   1 
ATOM   1017 C CA  . GLU C 2 93  ? -57.769 1.926   -67.773  1.00 30.52  ? 105  GLU B CA  1 
ATOM   1018 C C   . GLU C 2 93  ? -57.983 3.378   -68.192  1.00 34.82  ? 105  GLU B C   1 
ATOM   1019 O O   . GLU C 2 93  ? -57.535 3.783   -69.270  1.00 53.10  ? 105  GLU B O   1 
ATOM   1020 C CB  . GLU C 2 93  ? -58.882 1.038   -68.334  1.00 41.87  ? 105  GLU B CB  1 
ATOM   1021 C CG  . GLU C 2 93  ? -59.082 1.139   -69.840  1.00 52.25  ? 105  GLU B CG  1 
ATOM   1022 C CD  . GLU C 2 93  ? -59.545 -0.169  -70.457  1.00 74.02  ? 105  GLU B CD  1 
ATOM   1023 O OE1 . GLU C 2 93  ? -59.397 -1.225  -69.804  1.00 68.90  ? 105  GLU B OE1 1 
ATOM   1024 O OE2 . GLU C 2 93  ? -60.054 -0.140  -71.597  1.00 75.02  ? 105  GLU B OE2 1 
ATOM   1025 N N   . THR C 2 94  ? -58.634 4.182   -67.353  1.00 44.17  ? 106  THR B N   1 
ATOM   1026 C CA  . THR C 2 94  ? -59.015 5.533   -67.738  1.00 33.36  ? 106  THR B CA  1 
ATOM   1027 C C   . THR C 2 94  ? -58.361 6.631   -66.907  1.00 34.39  ? 106  THR B C   1 
ATOM   1028 O O   . THR C 2 94  ? -58.546 7.810   -67.225  1.00 43.65  ? 106  THR B O   1 
ATOM   1029 C CB  . THR C 2 94  ? -60.543 5.693   -67.664  1.00 23.71  ? 106  THR B CB  1 
ATOM   1030 O OG1 . THR C 2 94  ? -61.015 5.269   -66.379  1.00 25.69  ? 106  THR B OG1 1 
ATOM   1031 C CG2 . THR C 2 94  ? -61.214 4.863   -68.741  1.00 18.87  ? 106  THR B CG2 1 
ATOM   1032 N N   . ARG C 2 95  ? -57.592 6.291   -65.870  1.00 24.75  ? 107  ARG B N   1 
ATOM   1033 C CA  . ARG C 2 95  ? -57.112 7.315   -64.946  1.00 25.89  ? 107  ARG B CA  1 
ATOM   1034 C C   . ARG C 2 95  ? -56.226 8.341   -65.647  1.00 37.10  ? 107  ARG B C   1 
ATOM   1035 O O   . ARG C 2 95  ? -56.399 9.551   -65.464  1.00 43.70  ? 107  ARG B O   1 
ATOM   1036 C CB  . ARG C 2 95  ? -56.364 6.672   -63.778  1.00 34.77  ? 107  ARG B CB  1 
ATOM   1037 C CG  . ARG C 2 95  ? -56.244 7.595   -62.573  1.00 58.11  ? 107  ARG B CG  1 
ATOM   1038 C CD  . ARG C 2 95  ? -55.026 7.305   -61.707  1.00 66.49  ? 107  ARG B CD  1 
ATOM   1039 N NE  . ARG C 2 95  ? -53.899 6.772   -62.463  1.00 62.40  ? 107  ARG B NE  1 
ATOM   1040 C CZ  . ARG C 2 95  ? -53.536 5.497   -62.464  1.00 76.36  ? 107  ARG B CZ  1 
ATOM   1041 N NH1 . ARG C 2 95  ? -54.199 4.588   -61.765  1.00 79.41  ? 107  ARG B NH1 1 
ATOM   1042 N NH2 . ARG C 2 95  ? -52.482 5.123   -63.183  1.00 76.03  ? 107  ARG B NH2 1 
ATOM   1043 N N   . SER C 2 96  ? -55.271 7.881   -66.460  1.00 40.89  ? 108  SER B N   1 
ATOM   1044 C CA  . SER C 2 96  ? -54.306 8.813   -67.039  1.00 36.59  ? 108  SER B CA  1 
ATOM   1045 C C   . SER C 2 96  ? -54.956 9.722   -68.072  1.00 27.40  ? 108  SER B C   1 
ATOM   1046 O O   . SER C 2 96  ? -54.693 10.930  -68.090  1.00 38.02  ? 108  SER B O   1 
ATOM   1047 C CB  . SER C 2 96  ? -53.138 8.057   -67.662  1.00 41.36  ? 108  SER B CB  1 
ATOM   1048 O OG  . SER C 2 96  ? -52.381 7.388   -66.670  1.00 61.33  ? 108  SER B OG  1 
ATOM   1049 N N   . ALA C 2 97  ? -55.791 9.163   -68.950  1.00 26.22  ? 109  ALA B N   1 
ATOM   1050 C CA  . ALA C 2 97  ? -56.513 10.004  -69.899  1.00 26.91  ? 109  ALA B CA  1 
ATOM   1051 C C   . ALA C 2 97  ? -57.465 10.949  -69.182  1.00 31.63  ? 109  ALA B C   1 
ATOM   1052 O O   . ALA C 2 97  ? -57.735 12.052  -69.672  1.00 35.54  ? 109  ALA B O   1 
ATOM   1053 C CB  . ALA C 2 97  ? -57.274 9.137   -70.901  1.00 39.70  ? 109  ALA B CB  1 
ATOM   1054 N N   . PHE C 2 98  ? -57.975 10.536  -68.020  1.00 37.14  ? 110  PHE B N   1 
ATOM   1055 C CA  . PHE C 2 98  ? -58.825 11.406  -67.214  1.00 34.76  ? 110  PHE B CA  1 
ATOM   1056 C C   . PHE C 2 98  ? -58.040 12.610  -66.710  1.00 33.29  ? 110  PHE B C   1 
ATOM   1057 O O   . PHE C 2 98  ? -58.510 13.751  -66.788  1.00 38.45  ? 110  PHE B O   1 
ATOM   1058 C CB  . PHE C 2 98  ? -59.418 10.598  -66.057  1.00 34.41  ? 110  PHE B CB  1 
ATOM   1059 C CG  . PHE C 2 98  ? -60.043 11.427  -64.970  1.00 29.64  ? 110  PHE B CG  1 
ATOM   1060 C CD1 . PHE C 2 98  ? -59.300 11.833  -63.872  1.00 39.93  ? 110  PHE B CD1 1 
ATOM   1061 C CD2 . PHE C 2 98  ? -61.384 11.760  -65.023  1.00 29.18  ? 110  PHE B CD2 1 
ATOM   1062 C CE1 . PHE C 2 98  ? -59.878 12.579  -62.864  1.00 34.31  ? 110  PHE B CE1 1 
ATOM   1063 C CE2 . PHE C 2 98  ? -61.967 12.501  -64.015  1.00 25.63  ? 110  PHE B CE2 1 
ATOM   1064 C CZ  . PHE C 2 98  ? -61.213 12.915  -62.937  1.00 28.49  ? 110  PHE B CZ  1 
ATOM   1065 N N   . LEU C 2 99  ? -56.833 12.372  -66.190  1.00 31.56  ? 111  LEU B N   1 
ATOM   1066 C CA  . LEU C 2 99  ? -55.968 13.473  -65.783  1.00 22.04  ? 111  LEU B CA  1 
ATOM   1067 C C   . LEU C 2 99  ? -55.433 14.241  -66.983  1.00 25.62  ? 111  LEU B C   1 
ATOM   1068 O O   . LEU C 2 99  ? -55.117 15.430  -66.864  1.00 29.59  ? 111  LEU B O   1 
ATOM   1069 C CB  . LEU C 2 99  ? -54.808 12.945  -64.947  1.00 16.65  ? 111  LEU B CB  1 
ATOM   1070 C CG  . LEU C 2 99  ? -55.191 12.399  -63.581  1.00 15.46  ? 111  LEU B CG  1 
ATOM   1071 C CD1 . LEU C 2 99  ? -54.193 11.341  -63.140  1.00 33.14  ? 111  LEU B CD1 1 
ATOM   1072 C CD2 . LEU C 2 99  ? -55.254 13.545  -62.589  1.00 24.26  ? 111  LEU B CD2 1 
ATOM   1073 N N   . ALA C 2 100 ? -55.314 13.580  -68.137  1.00 20.17  ? 112  ALA B N   1 
ATOM   1074 C CA  . ALA C 2 100 ? -54.811 14.258  -69.325  1.00 25.25  ? 112  ALA B CA  1 
ATOM   1075 C C   . ALA C 2 100 ? -55.743 15.376  -69.766  1.00 30.36  ? 112  ALA B C   1 
ATOM   1076 O O   . ALA C 2 100 ? -55.284 16.394  -70.296  1.00 43.05  ? 112  ALA B O   1 
ATOM   1077 C CB  . ALA C 2 100 ? -54.608 13.251  -70.457  1.00 53.58  ? 112  ALA B CB  1 
ATOM   1078 N N   . ALA C 2 101 ? -57.047 15.211  -69.555  1.00 31.47  ? 113  ALA B N   1 
ATOM   1079 C CA  . ALA C 2 101 ? -58.021 16.248  -69.860  1.00 28.56  ? 113  ALA B CA  1 
ATOM   1080 C C   . ALA C 2 101 ? -58.219 17.223  -68.706  1.00 31.52  ? 113  ALA B C   1 
ATOM   1081 O O   . ALA C 2 101 ? -59.113 18.070  -68.776  1.00 42.26  ? 113  ALA B O   1 
ATOM   1082 C CB  . ALA C 2 101 ? -59.362 15.621  -70.246  1.00 18.52  ? 113  ALA B CB  1 
ATOM   1083 N N   . HIS C 2 102 ? -57.415 17.113  -67.648  1.00 25.56  ? 114  HIS B N   1 
ATOM   1084 C CA  . HIS C 2 102 ? -57.453 18.049  -66.524  1.00 31.59  ? 114  HIS B CA  1 
ATOM   1085 C C   . HIS C 2 102 ? -58.856 18.150  -65.926  1.00 20.65  ? 114  HIS B C   1 
ATOM   1086 O O   . HIS C 2 102 ? -59.284 19.210  -65.464  1.00 24.91  ? 114  HIS B O   1 
ATOM   1087 C CB  . HIS C 2 102 ? -56.941 19.429  -66.942  1.00 33.16  ? 114  HIS B CB  1 
ATOM   1088 C CG  . HIS C 2 102 ? -55.521 19.428  -67.417  1.00 34.01  ? 114  HIS B CG  1 
ATOM   1089 N ND1 . HIS C 2 102 ? -54.631 18.425  -67.098  1.00 43.43  ? 114  HIS B ND1 1 
ATOM   1090 C CD2 . HIS C 2 102 ? -54.829 20.321  -68.162  1.00 45.93  ? 114  HIS B CD2 1 
ATOM   1091 C CE1 . HIS C 2 102 ? -53.456 18.692  -67.641  1.00 46.49  ? 114  HIS B CE1 1 
ATOM   1092 N NE2 . HIS C 2 102 ? -53.549 19.838  -68.291  1.00 61.97  ? 114  HIS B NE2 1 
ATOM   1093 N N   . ILE C 2 103 ? -59.580 17.028  -65.933  1.00 15.88  ? 115  ILE B N   1 
ATOM   1094 C CA  . ILE C 2 103 ? -60.969 17.041  -65.466  1.00 12.11  ? 115  ILE B CA  1 
ATOM   1095 C C   . ILE C 2 103 ? -61.093 17.485  -64.015  1.00 13.90  ? 115  ILE B C   1 
ATOM   1096 O O   . ILE C 2 103 ? -61.988 18.289  -63.716  1.00 17.10  ? 115  ILE B O   1 
ATOM   1097 C CB  . ILE C 2 103 ? -61.631 15.685  -65.741  1.00 14.95  ? 115  ILE B CB  1 
ATOM   1098 C CG1 . ILE C 2 103 ? -61.788 15.493  -67.253  1.00 20.77  ? 115  ILE B CG1 1 
ATOM   1099 C CG2 . ILE C 2 103 ? -62.971 15.591  -65.024  1.00 11.08  ? 115  ILE B CG2 1 
ATOM   1100 C CD1 . ILE C 2 103 ? -63.053 14.784  -67.669  1.00 17.28  ? 115  ILE B CD1 1 
ATOM   1101 N N   . PRO C 2 104 ? -60.259 17.032  -63.071  1.00 26.77  ? 116  PRO B N   1 
ATOM   1102 C CA  . PRO C 2 104 ? -60.404 17.520  -61.689  1.00 20.36  ? 116  PRO B CA  1 
ATOM   1103 C C   . PRO C 2 104 ? -60.282 19.029  -61.549  1.00 22.39  ? 116  PRO B C   1 
ATOM   1104 O O   . PRO C 2 104 ? -60.700 19.569  -60.518  1.00 40.86  ? 116  PRO B O   1 
ATOM   1105 C CB  . PRO C 2 104 ? -59.277 16.797  -60.934  1.00 22.35  ? 116  PRO B CB  1 
ATOM   1106 C CG  . PRO C 2 104 ? -58.366 16.270  -61.991  1.00 24.07  ? 116  PRO B CG  1 
ATOM   1107 C CD  . PRO C 2 104 ? -59.252 15.960  -63.145  1.00 35.07  ? 116  PRO B CD  1 
ATOM   1108 N N   . LEU C 2 105 ? -59.740 19.730  -62.550  1.00 22.01  ? 117  LEU B N   1 
ATOM   1109 C CA  . LEU C 2 105 ? -59.637 21.183  -62.463  1.00 20.09  ? 117  LEU B CA  1 
ATOM   1110 C C   . LEU C 2 105 ? -60.998 21.854  -62.331  1.00 22.41  ? 117  LEU B C   1 
ATOM   1111 O O   . LEU C 2 105 ? -61.067 23.012  -61.903  1.00 28.49  ? 117  LEU B O   1 
ATOM   1112 C CB  . LEU C 2 105 ? -58.903 21.735  -63.685  1.00 10.08  ? 117  LEU B CB  1 
ATOM   1113 C CG  . LEU C 2 105 ? -57.403 21.979  -63.509  1.00 15.30  ? 117  LEU B CG  1 
ATOM   1114 C CD1 . LEU C 2 105 ? -56.797 22.531  -64.790  1.00 16.52  ? 117  LEU B CD1 1 
ATOM   1115 C CD2 . LEU C 2 105 ? -57.139 22.919  -62.340  1.00 21.26  ? 117  LEU B CD2 1 
ATOM   1116 N N   . PHE C 2 106 ? -62.079 21.154  -62.672  1.00 18.22  ? 118  PHE B N   1 
ATOM   1117 C CA  . PHE C 2 106 ? -63.414 21.729  -62.605  1.00 26.10  ? 118  PHE B CA  1 
ATOM   1118 C C   . PHE C 2 106 ? -64.134 21.434  -61.296  1.00 33.29  ? 118  PHE B C   1 
ATOM   1119 O O   . PHE C 2 106 ? -65.235 21.954  -61.087  1.00 39.26  ? 118  PHE B O   1 
ATOM   1120 C CB  . PHE C 2 106 ? -64.254 21.238  -63.785  1.00 19.53  ? 118  PHE B CB  1 
ATOM   1121 C CG  . PHE C 2 106 ? -63.876 21.878  -65.088  1.00 25.70  ? 118  PHE B CG  1 
ATOM   1122 C CD1 . PHE C 2 106 ? -64.245 23.184  -65.365  1.00 30.33  ? 118  PHE B CD1 1 
ATOM   1123 C CD2 . PHE C 2 106 ? -63.126 21.187  -66.022  1.00 27.15  ? 118  PHE B CD2 1 
ATOM   1124 C CE1 . PHE C 2 106 ? -63.890 23.781  -66.557  1.00 22.85  ? 118  PHE B CE1 1 
ATOM   1125 C CE2 . PHE C 2 106 ? -62.767 21.778  -67.219  1.00 36.62  ? 118  PHE B CE2 1 
ATOM   1126 C CZ  . PHE C 2 106 ? -63.151 23.078  -67.485  1.00 36.53  ? 118  PHE B CZ  1 
ATOM   1127 N N   . LEU C 2 107 ? -63.550 20.616  -60.419  1.00 24.54  ? 119  LEU B N   1 
ATOM   1128 C CA  . LEU C 2 107 ? -64.057 20.479  -59.061  1.00 16.04  ? 119  LEU B CA  1 
ATOM   1129 C C   . LEU C 2 107 ? -63.442 21.492  -58.113  1.00 19.06  ? 119  LEU B C   1 
ATOM   1130 O O   . LEU C 2 107 ? -64.003 21.738  -57.039  1.00 27.78  ? 119  LEU B O   1 
ATOM   1131 C CB  . LEU C 2 107 ? -63.790 19.073  -58.519  1.00 13.98  ? 119  LEU B CB  1 
ATOM   1132 C CG  . LEU C 2 107 ? -64.057 17.905  -59.464  1.00 22.67  ? 119  LEU B CG  1 
ATOM   1133 C CD1 . LEU C 2 107 ? -63.521 16.614  -58.864  1.00 23.28  ? 119  LEU B CD1 1 
ATOM   1134 C CD2 . LEU C 2 107 ? -65.543 17.793  -59.765  1.00 29.33  ? 119  LEU B CD2 1 
ATOM   1135 N N   . TYR C 2 108 ? -62.303 22.067  -58.488  1.00 22.38  ? 120  TYR B N   1 
ATOM   1136 C CA  . TYR C 2 108 ? -61.660 23.089  -57.667  1.00 27.84  ? 120  TYR B CA  1 
ATOM   1137 C C   . TYR C 2 108 ? -62.578 24.255  -57.318  1.00 31.79  ? 120  TYR B C   1 
ATOM   1138 O O   . TYR C 2 108 ? -62.469 24.766  -56.190  1.00 36.76  ? 120  TYR B O   1 
ATOM   1139 C CB  . TYR C 2 108 ? -60.398 23.601  -58.377  1.00 41.17  ? 120  TYR B CB  1 
ATOM   1140 C CG  . TYR C 2 108 ? -59.247 22.619  -58.411  1.00 36.70  ? 120  TYR B CG  1 
ATOM   1141 C CD1 . TYR C 2 108 ? -59.454 21.259  -58.214  1.00 29.40  ? 120  TYR B CD1 1 
ATOM   1142 C CD2 . TYR C 2 108 ? -57.952 23.053  -58.654  1.00 48.27  ? 120  TYR B CD2 1 
ATOM   1143 C CE1 . TYR C 2 108 ? -58.409 20.363  -58.254  1.00 30.06  ? 120  TYR B CE1 1 
ATOM   1144 C CE2 . TYR C 2 108 ? -56.899 22.165  -58.694  1.00 46.61  ? 120  TYR B CE2 1 
ATOM   1145 C CZ  . TYR C 2 108 ? -57.133 20.820  -58.494  1.00 37.44  ? 120  TYR B CZ  1 
ATOM   1146 O OH  . TYR C 2 108 ? -56.088 19.927  -58.531  1.00 50.21  ? 120  TYR B OH  1 
ATOM   1147 N N   . PRO C 2 109 ? -63.464 24.735  -58.201  1.00 26.54  ? 121  PRO B N   1 
ATOM   1148 C CA  . PRO C 2 109 ? -64.432 25.751  -57.760  1.00 22.02  ? 121  PRO B CA  1 
ATOM   1149 C C   . PRO C 2 109 ? -65.258 25.318  -56.563  1.00 28.66  ? 121  PRO B C   1 
ATOM   1150 O O   . PRO C 2 109 ? -65.610 26.161  -55.728  1.00 40.59  ? 121  PRO B O   1 
ATOM   1151 C CB  . PRO C 2 109 ? -65.303 25.957  -59.004  1.00 32.71  ? 121  PRO B CB  1 
ATOM   1152 C CG  . PRO C 2 109 ? -64.391 25.672  -60.134  1.00 31.33  ? 121  PRO B CG  1 
ATOM   1153 C CD  . PRO C 2 109 ? -63.510 24.550  -59.666  1.00 24.48  ? 121  PRO B CD  1 
ATOM   1154 N N   . PHE C 2 110 ? -65.566 24.023  -56.441  1.00 25.76  ? 122  PHE B N   1 
ATOM   1155 C CA  . PHE C 2 110 ? -66.346 23.561  -55.296  1.00 17.78  ? 122  PHE B CA  1 
ATOM   1156 C C   . PHE C 2 110 ? -65.527 23.593  -54.015  1.00 23.11  ? 122  PHE B C   1 
ATOM   1157 O O   . PHE C 2 110 ? -66.078 23.826  -52.934  1.00 37.23  ? 122  PHE B O   1 
ATOM   1158 C CB  . PHE C 2 110 ? -66.875 22.148  -55.537  1.00 19.48  ? 122  PHE B CB  1 
ATOM   1159 C CG  . PHE C 2 110 ? -67.669 21.998  -56.802  1.00 18.47  ? 122  PHE B CG  1 
ATOM   1160 C CD1 . PHE C 2 110 ? -68.242 23.097  -57.419  1.00 15.92  ? 122  PHE B CD1 1 
ATOM   1161 C CD2 . PHE C 2 110 ? -67.842 20.750  -57.374  1.00 27.72  ? 122  PHE B CD2 1 
ATOM   1162 C CE1 . PHE C 2 110 ? -68.964 22.955  -58.584  1.00 23.20  ? 122  PHE B CE1 1 
ATOM   1163 C CE2 . PHE C 2 110 ? -68.571 20.601  -58.539  1.00 32.08  ? 122  PHE B CE2 1 
ATOM   1164 C CZ  . PHE C 2 110 ? -69.133 21.705  -59.143  1.00 24.45  ? 122  PHE B CZ  1 
ATOM   1165 N N   . LEU C 2 111 ? -64.220 23.360  -54.111  1.00 24.67  ? 123  LEU B N   1 
ATOM   1166 C CA  . LEU C 2 111 ? -63.382 23.386  -52.920  1.00 30.74  ? 123  LEU B CA  1 
ATOM   1167 C C   . LEU C 2 111 ? -63.152 24.802  -52.407  1.00 37.50  ? 123  LEU B C   1 
ATOM   1168 O O   . LEU C 2 111 ? -62.749 24.971  -51.250  1.00 38.20  ? 123  LEU B O   1 
ATOM   1169 C CB  . LEU C 2 111 ? -62.049 22.699  -53.214  1.00 31.52  ? 123  LEU B CB  1 
ATOM   1170 C CG  . LEU C 2 111 ? -62.177 21.285  -53.789  1.00 22.49  ? 123  LEU B CG  1 
ATOM   1171 C CD1 . LEU C 2 111 ? -60.811 20.631  -53.925  1.00 13.33  ? 123  LEU B CD1 1 
ATOM   1172 C CD2 . LEU C 2 111 ? -63.104 20.428  -52.931  1.00 27.47  ? 123  LEU B CD2 1 
ATOM   1173 N N   . HIS C 2 112 ? -63.403 25.822  -53.232  1.00 30.55  ? 124  HIS B N   1 
ATOM   1174 C CA  . HIS C 2 112 ? -63.245 27.202  -52.790  1.00 39.05  ? 124  HIS B CA  1 
ATOM   1175 C C   . HIS C 2 112 ? -64.407 27.680  -51.930  1.00 47.97  ? 124  HIS B C   1 
ATOM   1176 O O   . HIS C 2 112 ? -64.271 28.698  -51.243  1.00 47.32  ? 124  HIS B O   1 
ATOM   1177 C CB  . HIS C 2 112 ? -63.088 28.128  -53.998  1.00 42.86  ? 124  HIS B CB  1 
ATOM   1178 C CG  . HIS C 2 112 ? -62.332 29.387  -53.703  1.00 62.21  ? 124  HIS B CG  1 
ATOM   1179 N ND1 . HIS C 2 112 ? -61.012 29.565  -54.061  1.00 64.90  ? 124  HIS B ND1 1 
ATOM   1180 C CD2 . HIS C 2 112 ? -62.713 30.533  -53.091  1.00 58.69  ? 124  HIS B CD2 1 
ATOM   1181 C CE1 . HIS C 2 112 ? -60.612 30.765  -53.678  1.00 55.94  ? 124  HIS B CE1 1 
ATOM   1182 N NE2 . HIS C 2 112 ? -61.625 31.373  -53.087  1.00 61.14  ? 124  HIS B NE2 1 
ATOM   1183 N N   . THR C 2 113 ? -65.531 26.964  -51.943  1.00 42.74  ? 125  THR B N   1 
ATOM   1184 C CA  . THR C 2 113 ? -66.732 27.400  -51.245  1.00 43.38  ? 125  THR B CA  1 
ATOM   1185 C C   . THR C 2 113 ? -66.541 27.327  -49.730  1.00 53.96  ? 125  THR B C   1 
ATOM   1186 O O   . THR C 2 113 ? -65.596 26.719  -49.216  1.00 45.13  ? 125  THR B O   1 
ATOM   1187 C CB  . THR C 2 113 ? -67.931 26.548  -51.657  1.00 35.92  ? 125  THR B CB  1 
ATOM   1188 O OG1 . THR C 2 113 ? -67.538 25.172  -51.722  1.00 45.71  ? 125  THR B OG1 1 
ATOM   1189 C CG2 . THR C 2 113 ? -68.446 26.984  -53.018  1.00 29.77  ? 125  THR B CG2 1 
ATOM   1190 N N   . VAL C 2 114 ? -67.473 27.955  -49.011  1.00 47.76  ? 126  VAL B N   1 
ATOM   1191 C CA  . VAL C 2 114 ? -67.390 28.081  -47.559  1.00 46.37  ? 126  VAL B CA  1 
ATOM   1192 C C   . VAL C 2 114 ? -68.789 28.074  -46.956  1.00 47.58  ? 126  VAL B C   1 
ATOM   1193 O O   . VAL C 2 114 ? -68.970 28.425  -45.784  1.00 54.81  ? 126  VAL B O   1 
ATOM   1194 C CB  . VAL C 2 114 ? -66.641 29.367  -47.161  1.00 30.02  ? 126  VAL B CB  1 
ATOM   1195 C CG1 . VAL C 2 114 ? -65.133 29.176  -47.260  1.00 49.14  ? 126  VAL B CG1 1 
ATOM   1196 C CG2 . VAL C 2 114 ? -67.095 30.529  -48.037  1.00 34.42  ? 126  VAL B CG2 1 
ATOM   1197 N N   . SER C 2 115 ? -69.785 27.658  -47.743  1.00 37.73  ? 127  SER B N   1 
ATOM   1198 C CA  . SER C 2 115 ? -71.174 27.934  -47.386  1.00 35.96  ? 127  SER B CA  1 
ATOM   1199 C C   . SER C 2 115 ? -71.635 27.176  -46.148  1.00 47.25  ? 127  SER B C   1 
ATOM   1200 O O   . SER C 2 115 ? -72.500 27.673  -45.417  1.00 84.63  ? 127  SER B O   1 
ATOM   1201 C CB  . SER C 2 115 ? -72.093 27.612  -48.558  1.00 53.90  ? 127  SER B CB  1 
ATOM   1202 O OG  . SER C 2 115 ? -73.424 28.013  -48.278  1.00 49.55  ? 127  SER B OG  1 
ATOM   1203 N N   . LYS C 2 116 ? -71.105 25.978  -45.905  1.00 34.64  ? 128  LYS B N   1 
ATOM   1204 C CA  . LYS C 2 116 ? -71.447 25.123  -44.767  1.00 68.12  ? 128  LYS B CA  1 
ATOM   1205 C C   . LYS C 2 116 ? -72.882 24.605  -44.808  1.00 49.25  ? 128  LYS B C   1 
ATOM   1206 O O   . LYS C 2 116 ? -73.293 23.895  -43.881  1.00 49.33  ? 128  LYS B O   1 
ATOM   1207 C CB  . LYS C 2 116 ? -71.220 25.820  -43.416  1.00 47.48  ? 128  LYS B CB  1 
ATOM   1208 C CG  . LYS C 2 116 ? -69.768 26.157  -43.126  1.00 57.59  ? 128  LYS B CG  1 
ATOM   1209 C CD  . LYS C 2 116 ? -69.013 24.947  -42.604  1.00 58.27  ? 128  LYS B CD  1 
ATOM   1210 C CE  . LYS C 2 116 ? -67.923 25.366  -41.629  1.00 59.70  ? 128  LYS B CE  1 
ATOM   1211 N NZ  . LYS C 2 116 ? -67.286 26.654  -42.029  1.00 44.77  ? 128  LYS B NZ  1 
ATOM   1212 N N   . THR C 2 117 ? -73.661 24.934  -45.835  1.00 51.65  ? 129  THR B N   1 
ATOM   1213 C CA  . THR C 2 117 ? -74.970 24.323  -45.999  1.00 40.71  ? 129  THR B CA  1 
ATOM   1214 C C   . THR C 2 117 ? -74.810 22.869  -46.426  1.00 43.60  ? 129  THR B C   1 
ATOM   1215 O O   . THR C 2 117 ? -73.866 22.510  -47.136  1.00 52.26  ? 129  THR B O   1 
ATOM   1216 C CB  . THR C 2 117 ? -75.791 25.078  -47.046  1.00 41.50  ? 129  THR B CB  1 
ATOM   1217 O OG1 . THR C 2 117 ? -75.420 26.462  -47.039  1.00 50.12  ? 129  THR B OG1 1 
ATOM   1218 C CG2 . THR C 2 117 ? -77.273 24.969  -46.733  1.00 40.10  ? 129  THR B CG2 1 
ATOM   1219 N N   . ARG C 2 118 ? -75.743 22.029  -45.985  1.00 33.53  ? 130  ARG B N   1 
ATOM   1220 C CA  . ARG C 2 118 ? -75.686 20.608  -46.324  1.00 40.11  ? 130  ARG B CA  1 
ATOM   1221 C C   . ARG C 2 118 ? -75.551 20.335  -47.820  1.00 47.73  ? 130  ARG B C   1 
ATOM   1222 O O   . ARG C 2 118 ? -74.802 19.409  -48.178  1.00 63.53  ? 130  ARG B O   1 
ATOM   1223 C CB  . ARG C 2 118 ? -76.917 19.894  -45.748  1.00 47.40  ? 130  ARG B CB  1 
ATOM   1224 C CG  . ARG C 2 118 ? -76.629 18.526  -45.140  1.00 39.33  ? 130  ARG B CG  1 
ATOM   1225 C CD  . ARG C 2 118 ? -77.850 18.021  -44.386  1.00 58.70  ? 130  ARG B CD  1 
ATOM   1226 N NE  . ARG C 2 118 ? -77.771 16.604  -44.055  1.00 56.32  ? 130  ARG B NE  1 
ATOM   1227 C CZ  . ARG C 2 118 ? -77.129 16.114  -43.004  1.00 62.66  ? 130  ARG B CZ  1 
ATOM   1228 N NH1 . ARG C 2 118 ? -76.462 16.899  -42.173  1.00 65.40  ? 130  ARG B NH1 1 
ATOM   1229 N NH2 . ARG C 2 118 ? -77.158 14.803  -42.779  1.00 65.14  ? 130  ARG B NH2 1 
ATOM   1230 N N   . PRO C 2 119 ? -76.218 21.058  -48.729  1.00 38.05  ? 131  PRO B N   1 
ATOM   1231 C CA  . PRO C 2 119 ? -75.913 20.866  -50.157  1.00 40.86  ? 131  PRO B CA  1 
ATOM   1232 C C   . PRO C 2 119 ? -74.494 21.260  -50.526  1.00 37.80  ? 131  PRO B C   1 
ATOM   1233 O O   . PRO C 2 119 ? -73.906 20.657  -51.432  1.00 33.62  ? 131  PRO B O   1 
ATOM   1234 C CB  . PRO C 2 119 ? -76.949 21.757  -50.859  1.00 43.49  ? 131  PRO B CB  1 
ATOM   1235 C CG  . PRO C 2 119 ? -77.359 22.750  -49.820  1.00 43.23  ? 131  PRO B CG  1 
ATOM   1236 C CD  . PRO C 2 119 ? -77.372 21.956  -48.554  1.00 45.96  ? 131  PRO B CD  1 
ATOM   1237 N N   . PHE C 2 120 ? -73.921 22.256  -49.852  1.00 30.93  ? 132  PHE B N   1 
ATOM   1238 C CA  . PHE C 2 120 ? -72.545 22.633  -50.146  1.00 24.35  ? 132  PHE B CA  1 
ATOM   1239 C C   . PHE C 2 120 ? -71.555 21.684  -49.488  1.00 39.34  ? 132  PHE B C   1 
ATOM   1240 O O   . PHE C 2 120 ? -70.499 21.391  -50.061  1.00 49.95  ? 132  PHE B O   1 
ATOM   1241 C CB  . PHE C 2 120 ? -72.288 24.065  -49.694  1.00 31.36  ? 132  PHE B CB  1 
ATOM   1242 C CG  . PHE C 2 120 ? -72.630 25.089  -50.727  1.00 38.60  ? 132  PHE B CG  1 
ATOM   1243 C CD1 . PHE C 2 120 ? -71.731 25.403  -51.729  1.00 39.14  ? 132  PHE B CD1 1 
ATOM   1244 C CD2 . PHE C 2 120 ? -73.851 25.740  -50.697  1.00 48.21  ? 132  PHE B CD2 1 
ATOM   1245 C CE1 . PHE C 2 120 ? -72.041 26.351  -52.683  1.00 42.08  ? 132  PHE B CE1 1 
ATOM   1246 C CE2 . PHE C 2 120 ? -74.163 26.697  -51.639  1.00 44.59  ? 132  PHE B CE2 1 
ATOM   1247 C CZ  . PHE C 2 120 ? -73.261 26.996  -52.640  1.00 40.31  ? 132  PHE B CZ  1 
ATOM   1248 N N   . GLU C 2 121 ? -71.873 21.196  -48.287  1.00 36.72  ? 133  GLU B N   1 
ATOM   1249 C CA  . GLU C 2 121 ? -70.988 20.239  -47.632  1.00 35.48  ? 133  GLU B CA  1 
ATOM   1250 C C   . GLU C 2 121 ? -70.952 18.917  -48.390  1.00 34.81  ? 133  GLU B C   1 
ATOM   1251 O O   . GLU C 2 121 ? -69.880 18.329  -48.565  1.00 43.09  ? 133  GLU B O   1 
ATOM   1252 C CB  . GLU C 2 121 ? -71.420 20.022  -46.182  1.00 40.18  ? 133  GLU B CB  1 
ATOM   1253 C CG  . GLU C 2 121 ? -70.363 19.358  -45.295  1.00 50.30  ? 133  GLU B CG  1 
ATOM   1254 C CD  . GLU C 2 121 ? -69.055 20.139  -45.210  1.00 61.54  ? 133  GLU B CD  1 
ATOM   1255 O OE1 . GLU C 2 121 ? -67.998 19.502  -45.011  1.00 56.50  ? 133  GLU B OE1 1 
ATOM   1256 O OE2 . GLU C 2 121 ? -69.078 21.385  -45.324  1.00 68.85  ? 133  GLU B OE2 1 
ATOM   1257 N N   . TYR C 2 122 ? -72.111 18.437  -48.853  1.00 27.73  ? 134  TYR B N   1 
ATOM   1258 C CA  . TYR C 2 122 ? -72.126 17.240  -49.689  1.00 34.77  ? 134  TYR B CA  1 
ATOM   1259 C C   . TYR C 2 122 ? -71.279 17.441  -50.940  1.00 39.67  ? 134  TYR B C   1 
ATOM   1260 O O   . TYR C 2 122 ? -70.497 16.561  -51.320  1.00 41.50  ? 134  TYR B O   1 
ATOM   1261 C CB  . TYR C 2 122 ? -73.561 16.874  -50.072  1.00 22.96  ? 134  TYR B CB  1 
ATOM   1262 C CG  . TYR C 2 122 ? -73.687 15.525  -50.755  1.00 22.86  ? 134  TYR B CG  1 
ATOM   1263 C CD1 . TYR C 2 122 ? -73.157 14.375  -50.181  1.00 38.82  ? 134  TYR B CD1 1 
ATOM   1264 C CD2 . TYR C 2 122 ? -74.285 15.414  -51.999  1.00 38.68  ? 134  TYR B CD2 1 
ATOM   1265 C CE1 . TYR C 2 122 ? -73.262 13.141  -50.814  1.00 40.04  ? 134  TYR B CE1 1 
ATOM   1266 C CE2 . TYR C 2 122 ? -74.406 14.188  -52.629  1.00 49.11  ? 134  TYR B CE2 1 
ATOM   1267 C CZ  . TYR C 2 122 ? -73.885 13.059  -52.041  1.00 43.99  ? 134  TYR B CZ  1 
ATOM   1268 O OH  . TYR C 2 122 ? -73.998 11.848  -52.692  1.00 42.33  ? 134  TYR B OH  1 
ATOM   1269 N N   . LEU C 2 123 ? -71.416 18.601  -51.590  1.00 33.03  ? 135  LEU B N   1 
ATOM   1270 C CA  . LEU C 2 123 ? -70.586 18.900  -52.751  1.00 28.46  ? 135  LEU B CA  1 
ATOM   1271 C C   . LEU C 2 123 ? -69.115 18.977  -52.369  1.00 37.57  ? 135  LEU B C   1 
ATOM   1272 O O   . LEU C 2 123 ? -68.252 18.454  -53.083  1.00 43.94  ? 135  LEU B O   1 
ATOM   1273 C CB  . LEU C 2 123 ? -71.037 20.207  -53.401  1.00 28.17  ? 135  LEU B CB  1 
ATOM   1274 C CG  . LEU C 2 123 ? -70.522 20.443  -54.823  1.00 31.05  ? 135  LEU B CG  1 
ATOM   1275 C CD1 . LEU C 2 123 ? -70.761 19.215  -55.687  1.00 38.21  ? 135  LEU B CD1 1 
ATOM   1276 C CD2 . LEU C 2 123 ? -71.171 21.670  -55.444  1.00 24.90  ? 135  LEU B CD2 1 
ATOM   1277 N N   . ARG C 2 124 ? -68.812 19.620  -51.237  1.00 28.17  ? 136  ARG B N   1 
ATOM   1278 C CA  . ARG C 2 124 ? -67.423 19.760  -50.815  1.00 23.32  ? 136  ARG B CA  1 
ATOM   1279 C C   . ARG C 2 124 ? -66.786 18.401  -50.549  1.00 29.25  ? 136  ARG B C   1 
ATOM   1280 O O   . ARG C 2 124 ? -65.655 18.143  -50.976  1.00 33.47  ? 136  ARG B O   1 
ATOM   1281 C CB  . ARG C 2 124 ? -67.343 20.647  -49.572  1.00 31.92  ? 136  ARG B CB  1 
ATOM   1282 C CG  . ARG C 2 124 ? -66.156 21.595  -49.559  1.00 27.09  ? 136  ARG B CG  1 
ATOM   1283 C CD  . ARG C 2 124 ? -66.327 22.700  -48.522  1.00 38.13  ? 136  ARG B CD  1 
ATOM   1284 N NE  . ARG C 2 124 ? -67.589 23.416  -48.672  1.00 41.20  ? 136  ARG B NE  1 
ATOM   1285 C CZ  . ARG C 2 124 ? -68.404 23.714  -47.669  1.00 48.67  ? 136  ARG B CZ  1 
ATOM   1286 N NH1 . ARG C 2 124 ? -68.121 23.368  -46.422  1.00 51.90  ? 136  ARG B NH1 1 
ATOM   1287 N NH2 . ARG C 2 124 ? -69.528 24.380  -47.920  1.00 33.33  ? 136  ARG B NH2 1 
ATOM   1288 N N   . LEU C 2 125 ? -67.504 17.513  -49.859  1.00 31.60  ? 137  LEU B N   1 
ATOM   1289 C CA  . LEU C 2 125 ? -66.940 16.212  -49.514  1.00 28.14  ? 137  LEU B CA  1 
ATOM   1290 C C   . LEU C 2 125 ? -66.820 15.320  -50.745  1.00 29.80  ? 137  LEU B C   1 
ATOM   1291 O O   . LEU C 2 125 ? -65.778 14.690  -50.966  1.00 32.68  ? 137  LEU B O   1 
ATOM   1292 C CB  . LEU C 2 125 ? -67.790 15.539  -48.434  1.00 32.07  ? 137  LEU B CB  1 
ATOM   1293 C CG  . LEU C 2 125 ? -67.933 16.277  -47.098  1.00 27.86  ? 137  LEU B CG  1 
ATOM   1294 C CD1 . LEU C 2 125 ? -69.182 15.828  -46.350  1.00 12.76  ? 137  LEU B CD1 1 
ATOM   1295 C CD2 . LEU C 2 125 ? -66.695 16.099  -46.229  1.00 35.87  ? 137  LEU B CD2 1 
ATOM   1296 N N   . THR C 2 126 ? -67.878 15.252  -51.559  1.00 26.78  ? 138  THR B N   1 
ATOM   1297 C CA  . THR C 2 126 ? -67.834 14.418  -52.757  1.00 28.61  ? 138  THR B CA  1 
ATOM   1298 C C   . THR C 2 126 ? -66.721 14.861  -53.697  1.00 32.12  ? 138  THR B C   1 
ATOM   1299 O O   . THR C 2 126 ? -66.074 14.028  -54.344  1.00 35.03  ? 138  THR B O   1 
ATOM   1300 C CB  . THR C 2 126 ? -69.186 14.446  -53.471  1.00 25.35  ? 138  THR B CB  1 
ATOM   1301 O OG1 . THR C 2 126 ? -70.217 14.040  -52.561  1.00 34.84  ? 138  THR B OG1 1 
ATOM   1302 C CG2 . THR C 2 126 ? -69.182 13.510  -54.668  1.00 25.56  ? 138  THR B CG2 1 
ATOM   1303 N N   . SER C 2 127 ? -66.476 16.171  -53.780  1.00 32.73  ? 139  SER B N   1 
ATOM   1304 C CA  . SER C 2 127 ? -65.338 16.657  -54.554  1.00 28.32  ? 139  SER B CA  1 
ATOM   1305 C C   . SER C 2 127 ? -64.023 16.280  -53.887  1.00 24.03  ? 139  SER B C   1 
ATOM   1306 O O   . SER C 2 127 ? -63.066 15.888  -54.565  1.00 29.93  ? 139  SER B O   1 
ATOM   1307 C CB  . SER C 2 127 ? -65.431 18.171  -54.738  1.00 30.35  ? 139  SER B CB  1 
ATOM   1308 O OG  . SER C 2 127 ? -66.605 18.526  -55.448  1.00 31.24  ? 139  SER B OG  1 
ATOM   1309 N N   . LEU C 2 128 ? -63.955 16.391  -52.559  1.00 22.88  ? 140  LEU B N   1 
ATOM   1310 C CA  . LEU C 2 128 ? -62.755 15.957  -51.853  1.00 29.78  ? 140  LEU B CA  1 
ATOM   1311 C C   . LEU C 2 128 ? -62.549 14.456  -51.996  1.00 32.32  ? 140  LEU B C   1 
ATOM   1312 O O   . LEU C 2 128 ? -61.413 13.987  -52.137  1.00 38.38  ? 140  LEU B O   1 
ATOM   1313 C CB  . LEU C 2 128 ? -62.840 16.349  -50.379  1.00 18.01  ? 140  LEU B CB  1 
ATOM   1314 C CG  . LEU C 2 128 ? -62.544 17.819  -50.082  1.00 21.88  ? 140  LEU B CG  1 
ATOM   1315 C CD1 . LEU C 2 128 ? -62.810 18.142  -48.622  1.00 22.34  ? 140  LEU B CD1 1 
ATOM   1316 C CD2 . LEU C 2 128 ? -61.114 18.160  -50.461  1.00 15.45  ? 140  LEU B CD2 1 
ATOM   1317 N N   . GLY C 2 129 ? -63.639 13.686  -51.972  1.00 29.61  ? 141  GLY B N   1 
ATOM   1318 C CA  . GLY C 2 129 ? -63.515 12.245  -52.109  1.00 31.50  ? 141  GLY B CA  1 
ATOM   1319 C C   . GLY C 2 129 ? -62.904 11.841  -53.435  1.00 29.32  ? 141  GLY B C   1 
ATOM   1320 O O   . GLY C 2 129 ? -62.146 10.871  -53.512  1.00 45.59  ? 141  GLY B O   1 
ATOM   1321 N N   . VAL C 2 130 ? -63.220 12.584  -54.496  1.00 35.78  ? 142  VAL B N   1 
ATOM   1322 C CA  . VAL C 2 130 ? -62.620 12.305  -55.796  1.00 33.08  ? 142  VAL B CA  1 
ATOM   1323 C C   . VAL C 2 130 ? -61.112 12.503  -55.737  1.00 24.95  ? 142  VAL B C   1 
ATOM   1324 O O   . VAL C 2 130 ? -60.343 11.685  -56.257  1.00 25.68  ? 142  VAL B O   1 
ATOM   1325 C CB  . VAL C 2 130 ? -63.267 13.185  -56.879  1.00 28.99  ? 142  VAL B CB  1 
ATOM   1326 C CG1 . VAL C 2 130 ? -62.405 13.201  -58.124  1.00 27.62  ? 142  VAL B CG1 1 
ATOM   1327 C CG2 . VAL C 2 130 ? -64.668 12.683  -57.193  1.00 39.86  ? 142  VAL B CG2 1 
ATOM   1328 N N   . ILE C 2 131 ? -60.662 13.580  -55.089  1.00 24.54  ? 143  ILE B N   1 
ATOM   1329 C CA  . ILE C 2 131 ? -59.228 13.816  -54.967  1.00 20.67  ? 143  ILE B CA  1 
ATOM   1330 C C   . ILE C 2 131 ? -58.595 12.782  -54.048  1.00 31.28  ? 143  ILE B C   1 
ATOM   1331 O O   . ILE C 2 131 ? -57.522 12.241  -54.345  1.00 29.72  ? 143  ILE B O   1 
ATOM   1332 C CB  . ILE C 2 131 ? -58.955 15.248  -54.478  1.00 15.26  ? 143  ILE B CB  1 
ATOM   1333 C CG1 . ILE C 2 131 ? -59.687 16.259  -55.356  1.00 14.98  ? 143  ILE B CG1 1 
ATOM   1334 C CG2 . ILE C 2 131 ? -57.466 15.530  -54.505  1.00 23.69  ? 143  ILE B CG2 1 
ATOM   1335 C CD1 . ILE C 2 131 ? -59.450 16.057  -56.830  1.00 12.10  ? 143  ILE B CD1 1 
ATOM   1336 N N   . GLY C 2 132 ? -59.244 12.492  -52.917  1.00 31.57  ? 144  GLY B N   1 
ATOM   1337 C CA  . GLY C 2 132 ? -58.759 11.440  -52.040  1.00 22.06  ? 144  GLY B CA  1 
ATOM   1338 C C   . GLY C 2 132 ? -58.666 10.092  -52.727  1.00 28.18  ? 144  GLY B C   1 
ATOM   1339 O O   . GLY C 2 132 ? -57.837 9.258   -52.356  1.00 39.23  ? 144  GLY B O   1 
ATOM   1340 N N   . ALA C 2 133 ? -59.508 9.860   -53.737  1.00 17.35  ? 145  ALA B N   1 
ATOM   1341 C CA  . ALA C 2 133 ? -59.402 8.629   -54.509  1.00 19.05  ? 145  ALA B CA  1 
ATOM   1342 C C   . ALA C 2 133 ? -58.124 8.610   -55.336  1.00 34.70  ? 145  ALA B C   1 
ATOM   1343 O O   . ALA C 2 133 ? -57.444 7.580   -55.417  1.00 48.70  ? 145  ALA B O   1 
ATOM   1344 C CB  . ALA C 2 133 ? -60.627 8.464   -55.407  1.00 34.51  ? 145  ALA B CB  1 
ATOM   1345 N N   . LEU C 2 134 ? -57.776 9.744   -55.948  1.00 27.30  ? 146  LEU B N   1 
ATOM   1346 C CA  . LEU C 2 134 ? -56.575 9.809   -56.776  1.00 20.89  ? 146  LEU B CA  1 
ATOM   1347 C C   . LEU C 2 134 ? -55.312 9.647   -55.941  1.00 37.64  ? 146  LEU B C   1 
ATOM   1348 O O   . LEU C 2 134 ? -54.378 8.944   -56.347  1.00 46.61  ? 146  LEU B O   1 
ATOM   1349 C CB  . LEU C 2 134 ? -56.535 11.132  -57.536  1.00 17.52  ? 146  LEU B CB  1 
ATOM   1350 C CG  . LEU C 2 134 ? -57.163 11.165  -58.927  1.00 22.81  ? 146  LEU B CG  1 
ATOM   1351 C CD1 . LEU C 2 134 ? -58.647 10.900  -58.838  1.00 36.34  ? 146  LEU B CD1 1 
ATOM   1352 C CD2 . LEU C 2 134 ? -56.909 12.508  -59.570  1.00 23.65  ? 146  LEU B CD2 1 
ATOM   1353 N N   . VAL C 2 135 ? -55.256 10.295  -54.776  1.00 29.85  ? 147  VAL B N   1 
ATOM   1354 C CA  . VAL C 2 135 ? -54.047 10.236  -53.966  1.00 29.76  ? 147  VAL B CA  1 
ATOM   1355 C C   . VAL C 2 135 ? -53.831 8.850   -53.375  1.00 42.22  ? 147  VAL B C   1 
ATOM   1356 O O   . VAL C 2 135 ? -52.697 8.502   -53.023  1.00 48.30  ? 147  VAL B O   1 
ATOM   1357 C CB  . VAL C 2 135 ? -54.093 11.305  -52.860  1.00 22.37  ? 147  VAL B CB  1 
ATOM   1358 C CG1 . VAL C 2 135 ? -54.445 12.653  -53.454  1.00 25.29  ? 147  VAL B CG1 1 
ATOM   1359 C CG2 . VAL C 2 135 ? -55.092 10.919  -51.788  1.00 30.87  ? 147  VAL B CG2 1 
ATOM   1360 N N   . LYS C 2 136 ? -54.886 8.040   -53.265  1.00 31.77  ? 148  LYS B N   1 
ATOM   1361 C CA  . LYS C 2 136 ? -54.731 6.697   -52.723  1.00 39.36  ? 148  LYS B CA  1 
ATOM   1362 C C   . LYS C 2 136 ? -54.083 5.739   -53.710  1.00 48.52  ? 148  LYS B C   1 
ATOM   1363 O O   . LYS C 2 136 ? -53.483 4.746   -53.284  1.00 60.33  ? 148  LYS B O   1 
ATOM   1364 C CB  . LYS C 2 136 ? -56.086 6.147   -52.276  1.00 35.91  ? 148  LYS B CB  1 
ATOM   1365 C CG  . LYS C 2 136 ? -56.534 6.677   -50.926  1.00 35.46  ? 148  LYS B CG  1 
ATOM   1366 C CD  . LYS C 2 136 ? -57.277 5.618   -50.131  1.00 50.12  ? 148  LYS B CD  1 
ATOM   1367 C CE  . LYS C 2 136 ? -56.467 5.159   -48.927  1.00 60.33  ? 148  LYS B CE  1 
ATOM   1368 N NZ  . LYS C 2 136 ? -57.316 4.442   -47.929  1.00 55.14  ? 148  LYS B NZ  1 
ATOM   1369 N N   . THR C 2 137 ? -54.185 6.014   -55.012  1.00 39.40  ? 149  THR B N   1 
ATOM   1370 C CA  . THR C 2 137 ? -53.495 5.196   -56.001  1.00 40.63  ? 149  THR B CA  1 
ATOM   1371 C C   . THR C 2 137 ? -51.983 5.288   -55.869  1.00 49.63  ? 149  THR B C   1 
ATOM   1372 O O   . THR C 2 137 ? -51.276 4.396   -56.350  1.00 63.59  ? 149  THR B O   1 
ATOM   1373 C CB  . THR C 2 137 ? -53.903 5.613   -57.412  1.00 48.60  ? 149  THR B CB  1 
ATOM   1374 O OG1 . THR C 2 137 ? -53.055 6.682   -57.852  1.00 53.60  ? 149  THR B OG1 1 
ATOM   1375 C CG2 . THR C 2 137 ? -55.353 6.071   -57.440  1.00 61.10  ? 149  THR B CG2 1 
ATOM   1376 N N   . ASP C 2 138 ? -51.476 6.353   -55.245  1.00 54.05  ? 150  ASP B N   1 
ATOM   1377 C CA  . ASP C 2 138 ? -50.042 6.551   -55.042  1.00 55.77  ? 150  ASP B CA  1 
ATOM   1378 C C   . ASP C 2 138 ? -49.274 6.564   -56.360  1.00 51.22  ? 150  ASP B C   1 
ATOM   1379 O O   . ASP C 2 138 ? -48.089 6.226   -56.403  1.00 61.06  ? 150  ASP B O   1 
ATOM   1380 C CB  . ASP C 2 138 ? -49.464 5.495   -54.098  1.00 64.59  ? 150  ASP B CB  1 
ATOM   1381 C CG  . ASP C 2 138 ? -48.516 6.087   -53.084  1.00 92.67  ? 150  ASP B CG  1 
ATOM   1382 O OD1 . ASP C 2 138 ? -48.289 7.315   -53.136  1.00 91.51  ? 150  ASP B OD1 1 
ATOM   1383 O OD2 . ASP C 2 138 ? -47.999 5.329   -52.235  1.00 108.49 ? 150  ASP B OD2 1 
ATOM   1384 N N   . GLU C 2 139 ? -49.942 6.952   -57.443  1.00 44.30  ? 151  GLU B N   1 
ATOM   1385 C CA  . GLU C 2 139 ? -49.291 7.038   -58.741  1.00 47.51  ? 151  GLU B CA  1 
ATOM   1386 C C   . GLU C 2 139 ? -48.439 8.297   -58.829  1.00 34.92  ? 151  GLU B C   1 
ATOM   1387 O O   . GLU C 2 139 ? -48.745 9.326   -58.220  1.00 50.50  ? 151  GLU B O   1 
ATOM   1388 C CB  . GLU C 2 139 ? -50.324 7.032   -59.869  1.00 49.08  ? 151  GLU B CB  1 
ATOM   1389 C CG  . GLU C 2 139 ? -51.040 5.705   -60.059  1.00 67.77  ? 151  GLU B CG  1 
ATOM   1390 C CD  . GLU C 2 139 ? -50.108 4.593   -60.499  1.00 81.24  ? 151  GLU B CD  1 
ATOM   1391 O OE1 . GLU C 2 139 ? -49.475 4.731   -61.568  1.00 89.40  ? 151  GLU B OE1 1 
ATOM   1392 O OE2 . GLU C 2 139 ? -50.009 3.579   -59.774  1.00 79.72  ? 151  GLU B OE2 1 
ATOM   1393 N N   . GLN C 2 140 ? -47.352 8.202   -59.595  1.00 29.26  ? 152  GLN B N   1 
ATOM   1394 C CA  . GLN C 2 140 ? -46.481 9.358   -59.775  1.00 36.15  ? 152  GLN B CA  1 
ATOM   1395 C C   . GLN C 2 140 ? -47.206 10.479  -60.507  1.00 43.46  ? 152  GLN B C   1 
ATOM   1396 O O   . GLN C 2 140 ? -47.043 11.657  -60.168  1.00 47.27  ? 152  GLN B O   1 
ATOM   1397 C CB  . GLN C 2 140 ? -45.216 8.950   -60.530  1.00 46.14  ? 152  GLN B CB  1 
ATOM   1398 C CG  . GLN C 2 140 ? -43.999 9.818   -60.238  1.00 50.13  ? 152  GLN B CG  1 
ATOM   1399 C CD  . GLN C 2 140 ? -43.924 10.261  -58.787  1.00 62.82  ? 152  GLN B CD  1 
ATOM   1400 O OE1 . GLN C 2 140 ? -44.014 11.452  -58.485  1.00 62.50  ? 152  GLN B OE1 1 
ATOM   1401 N NE2 . GLN C 2 140 ? -43.755 9.302   -57.881  1.00 67.89  ? 152  GLN B NE2 1 
ATOM   1402 N N   . GLU C 2 141 ? -48.019 10.128  -61.506  1.00 42.13  ? 153  GLU B N   1 
ATOM   1403 C CA  . GLU C 2 141 ? -48.728 11.141  -62.281  1.00 35.90  ? 153  GLU B CA  1 
ATOM   1404 C C   . GLU C 2 141 ? -49.696 11.928  -61.407  1.00 40.49  ? 153  GLU B C   1 
ATOM   1405 O O   . GLU C 2 141 ? -49.889 13.133  -61.613  1.00 49.34  ? 153  GLU B O   1 
ATOM   1406 C CB  . GLU C 2 141 ? -49.473 10.483  -63.440  1.00 46.72  ? 153  GLU B CB  1 
ATOM   1407 C CG  . GLU C 2 141 ? -50.158 9.179   -63.061  1.00 55.23  ? 153  GLU B CG  1 
ATOM   1408 C CD  . GLU C 2 141 ? -50.888 8.534   -64.224  1.00 69.42  ? 153  GLU B CD  1 
ATOM   1409 O OE1 . GLU C 2 141 ? -50.881 9.111   -65.335  1.00 57.32  ? 153  GLU B OE1 1 
ATOM   1410 O OE2 . GLU C 2 141 ? -51.471 7.446   -64.025  1.00 69.69  ? 153  GLU B OE2 1 
ATOM   1411 N N   . VAL C 2 142 ? -50.313 11.265  -60.427  1.00 30.06  ? 154  VAL B N   1 
ATOM   1412 C CA  . VAL C 2 142 ? -51.275 11.943  -59.562  1.00 25.64  ? 154  VAL B CA  1 
ATOM   1413 C C   . VAL C 2 142 ? -50.586 13.043  -58.765  1.00 38.92  ? 154  VAL B C   1 
ATOM   1414 O O   . VAL C 2 142 ? -51.048 14.190  -58.728  1.00 43.68  ? 154  VAL B O   1 
ATOM   1415 C CB  . VAL C 2 142 ? -51.981 10.930  -58.643  1.00 26.14  ? 154  VAL B CB  1 
ATOM   1416 C CG1 . VAL C 2 142 ? -52.739 11.650  -57.542  1.00 20.29  ? 154  VAL B CG1 1 
ATOM   1417 C CG2 . VAL C 2 142 ? -52.927 10.055  -59.452  1.00 26.56  ? 154  VAL B CG2 1 
ATOM   1418 N N   . ILE C 2 143 ? -49.460 12.714  -58.129  1.00 41.64  ? 155  ILE B N   1 
ATOM   1419 C CA  . ILE C 2 143 ? -48.732 13.710  -57.347  1.00 32.00  ? 155  ILE B CA  1 
ATOM   1420 C C   . ILE C 2 143 ? -48.222 14.827  -58.254  1.00 38.74  ? 155  ILE B C   1 
ATOM   1421 O O   . ILE C 2 143 ? -48.331 16.015  -57.923  1.00 38.42  ? 155  ILE B O   1 
ATOM   1422 C CB  . ILE C 2 143 ? -47.587 13.043  -56.558  1.00 32.01  ? 155  ILE B CB  1 
ATOM   1423 C CG1 . ILE C 2 143 ? -48.076 12.544  -55.192  1.00 38.13  ? 155  ILE B CG1 1 
ATOM   1424 C CG2 . ILE C 2 143 ? -46.419 14.002  -56.376  1.00 33.09  ? 155  ILE B CG2 1 
ATOM   1425 C CD1 . ILE C 2 143 ? -49.065 11.388  -55.252  1.00 43.40  ? 155  ILE B CD1 1 
ATOM   1426 N N   . ASN C 2 144 ? -47.680 14.466  -59.422  1.00 39.48  ? 156  ASN B N   1 
ATOM   1427 C CA  . ASN C 2 144 ? -47.150 15.474  -60.337  1.00 40.70  ? 156  ASN B CA  1 
ATOM   1428 C C   . ASN C 2 144 ? -48.245 16.389  -60.866  1.00 39.97  ? 156  ASN B C   1 
ATOM   1429 O O   . ASN C 2 144 ? -47.987 17.566  -61.145  1.00 37.04  ? 156  ASN B O   1 
ATOM   1430 C CB  . ASN C 2 144 ? -46.417 14.802  -61.498  1.00 55.24  ? 156  ASN B CB  1 
ATOM   1431 C CG  . ASN C 2 144 ? -44.972 14.482  -61.170  1.00 55.25  ? 156  ASN B CG  1 
ATOM   1432 O OD1 . ASN C 2 144 ? -44.253 15.306  -60.598  1.00 43.00  ? 156  ASN B OD1 1 
ATOM   1433 N ND2 . ASN C 2 144 ? -44.535 13.279  -61.533  1.00 48.36  ? 156  ASN B ND2 1 
ATOM   1434 N N   . PHE C 2 145 ? -49.465 15.871  -61.014  1.00 36.56  ? 157  PHE B N   1 
ATOM   1435 C CA  . PHE C 2 145 ? -50.579 16.709  -61.440  1.00 34.12  ? 157  PHE B CA  1 
ATOM   1436 C C   . PHE C 2 145 ? -50.958 17.692  -60.337  1.00 42.10  ? 157  PHE B C   1 
ATOM   1437 O O   . PHE C 2 145 ? -50.874 18.910  -60.523  1.00 58.44  ? 157  PHE B O   1 
ATOM   1438 C CB  . PHE C 2 145 ? -51.766 15.826  -61.845  1.00 23.80  ? 157  PHE B CB  1 
ATOM   1439 C CG  . PHE C 2 145 ? -53.031 16.585  -62.167  1.00 23.63  ? 157  PHE B CG  1 
ATOM   1440 C CD1 . PHE C 2 145 ? -53.973 16.857  -61.185  1.00 29.94  ? 157  PHE B CD1 1 
ATOM   1441 C CD2 . PHE C 2 145 ? -53.284 17.011  -63.461  1.00 38.07  ? 157  PHE B CD2 1 
ATOM   1442 C CE1 . PHE C 2 145 ? -55.138 17.545  -61.489  1.00 36.84  ? 157  PHE B CE1 1 
ATOM   1443 C CE2 . PHE C 2 145 ? -54.446 17.703  -63.772  1.00 30.59  ? 157  PHE B CE2 1 
ATOM   1444 C CZ  . PHE C 2 145 ? -55.373 17.971  -62.785  1.00 24.74  ? 157  PHE B CZ  1 
ATOM   1445 N N   . LEU C 2 146 ? -51.325 17.174  -59.160  1.00 30.28  ? 158  LEU B N   1 
ATOM   1446 C CA  . LEU C 2 146 ? -51.920 18.013  -58.121  1.00 35.55  ? 158  LEU B CA  1 
ATOM   1447 C C   . LEU C 2 146 ? -51.006 19.167  -57.723  1.00 42.03  ? 158  LEU B C   1 
ATOM   1448 O O   . LEU C 2 146 ? -51.485 20.268  -57.427  1.00 52.35  ? 158  LEU B O   1 
ATOM   1449 C CB  . LEU C 2 146 ? -52.268 17.162  -56.901  1.00 25.43  ? 158  LEU B CB  1 
ATOM   1450 C CG  . LEU C 2 146 ? -53.220 15.992  -57.157  1.00 26.33  ? 158  LEU B CG  1 
ATOM   1451 C CD1 . LEU C 2 146 ? -53.286 15.085  -55.941  1.00 36.80  ? 158  LEU B CD1 1 
ATOM   1452 C CD2 . LEU C 2 146 ? -54.605 16.489  -57.533  1.00 26.60  ? 158  LEU B CD2 1 
ATOM   1453 N N   . LEU C 2 147 ? -49.690 18.938  -57.709  1.00 32.10  ? 159  LEU B N   1 
ATOM   1454 C CA  . LEU C 2 147 ? -48.763 20.006  -57.347  1.00 32.30  ? 159  LEU B CA  1 
ATOM   1455 C C   . LEU C 2 147 ? -48.845 21.167  -58.331  1.00 43.51  ? 159  LEU B C   1 
ATOM   1456 O O   . LEU C 2 147 ? -48.804 22.337  -57.932  1.00 60.10  ? 159  LEU B O   1 
ATOM   1457 C CB  . LEU C 2 147 ? -47.334 19.465  -57.282  1.00 32.89  ? 159  LEU B CB  1 
ATOM   1458 C CG  . LEU C 2 147 ? -47.014 18.435  -56.196  1.00 38.37  ? 159  LEU B CG  1 
ATOM   1459 C CD1 . LEU C 2 147 ? -45.694 17.736  -56.491  1.00 36.83  ? 159  LEU B CD1 1 
ATOM   1460 C CD2 . LEU C 2 147 ? -46.979 19.084  -54.825  1.00 39.32  ? 159  LEU B CD2 1 
ATOM   1461 N N   . THR C 2 148 ? -48.973 20.862  -59.621  1.00 31.92  ? 160  THR B N   1 
ATOM   1462 C CA  . THR C 2 148 ? -48.964 21.907  -60.636  1.00 35.61  ? 160  THR B CA  1 
ATOM   1463 C C   . THR C 2 148 ? -50.277 22.679  -60.676  1.00 53.55  ? 160  THR B C   1 
ATOM   1464 O O   . THR C 2 148 ? -50.297 23.840  -61.103  1.00 58.48  ? 160  THR B O   1 
ATOM   1465 C CB  . THR C 2 148 ? -48.681 21.287  -61.997  1.00 45.05  ? 160  THR B CB  1 
ATOM   1466 O OG1 . THR C 2 148 ? -49.642 20.254  -62.247  1.00 56.17  ? 160  THR B OG1 1 
ATOM   1467 C CG2 . THR C 2 148 ? -47.296 20.677  -62.007  1.00 52.09  ? 160  THR B CG2 1 
ATOM   1468 N N   . THR C 2 149 ? -51.377 22.058  -60.249  1.00 55.06  ? 161  THR B N   1 
ATOM   1469 C CA  . THR C 2 149 ? -52.696 22.674  -60.330  1.00 46.34  ? 161  THR B CA  1 
ATOM   1470 C C   . THR C 2 149 ? -53.022 23.583  -59.158  1.00 49.03  ? 161  THR B C   1 
ATOM   1471 O O   . THR C 2 149 ? -54.073 24.234  -59.183  1.00 54.13  ? 161  THR B O   1 
ATOM   1472 C CB  . THR C 2 149 ? -53.775 21.601  -60.434  1.00 37.81  ? 161  THR B CB  1 
ATOM   1473 O OG1 . THR C 2 149 ? -54.097 21.117  -59.120  1.00 47.13  ? 161  THR B OG1 1 
ATOM   1474 C CG2 . THR C 2 149 ? -53.329 20.467  -61.329  1.00 39.90  ? 161  THR B CG2 1 
ATOM   1475 N N   . GLU C 2 150 ? -52.165 23.639  -58.141  1.00 49.85  ? 162  GLU B N   1 
ATOM   1476 C CA  . GLU C 2 150 ? -52.416 24.440  -56.944  1.00 53.98  ? 162  GLU B CA  1 
ATOM   1477 C C   . GLU C 2 150 ? -53.680 23.955  -56.228  1.00 43.82  ? 162  GLU B C   1 
ATOM   1478 O O   . GLU C 2 150 ? -54.638 24.699  -56.014  1.00 44.44  ? 162  GLU B O   1 
ATOM   1479 C CB  . GLU C 2 150 ? -52.507 25.932  -57.292  1.00 52.65  ? 162  GLU B CB  1 
ATOM   1480 C CG  . GLU C 2 150 ? -51.206 26.577  -57.775  1.00 64.16  ? 162  GLU B CG  1 
ATOM   1481 C CD  . GLU C 2 150 ? -50.112 26.627  -56.709  1.00 95.26  ? 162  GLU B CD  1 
ATOM   1482 O OE1 . GLU C 2 150 ? -49.733 25.570  -56.158  1.00 86.00  ? 162  GLU B OE1 1 
ATOM   1483 O OE2 . GLU C 2 150 ? -49.627 27.743  -56.423  1.00 109.92 ? 162  GLU B OE2 1 
ATOM   1484 N N   . ILE C 2 151 ? -53.669 22.671  -55.873  1.00 42.46  ? 163  ILE B N   1 
ATOM   1485 C CA  . ILE C 2 151 ? -54.679 22.151  -54.960  1.00 35.80  ? 163  ILE B CA  1 
ATOM   1486 C C   . ILE C 2 151 ? -54.240 22.329  -53.512  1.00 34.33  ? 163  ILE B C   1 
ATOM   1487 O O   . ILE C 2 151 ? -55.086 22.426  -52.617  1.00 49.33  ? 163  ILE B O   1 
ATOM   1488 C CB  . ILE C 2 151 ? -54.996 20.677  -55.259  1.00 39.64  ? 163  ILE B CB  1 
ATOM   1489 C CG1 . ILE C 2 151 ? -56.192 20.212  -54.423  1.00 24.01  ? 163  ILE B CG1 1 
ATOM   1490 C CG2 . ILE C 2 151 ? -53.785 19.797  -54.987  1.00 27.69  ? 163  ILE B CG2 1 
ATOM   1491 C CD1 . ILE C 2 151 ? -57.074 19.206  -55.119  1.00 49.54  ? 163  ILE B CD1 1 
ATOM   1492 N N   . ILE C 2 152 ? -52.930 22.383  -53.264  1.00 31.43  ? 164  ILE B N   1 
ATOM   1493 C CA  . ILE C 2 152 ? -52.438 22.644  -51.909  1.00 24.11  ? 164  ILE B CA  1 
ATOM   1494 C C   . ILE C 2 152 ? -53.008 23.944  -51.351  1.00 31.34  ? 164  ILE B C   1 
ATOM   1495 O O   . ILE C 2 152 ? -53.519 23.931  -50.216  1.00 34.25  ? 164  ILE B O   1 
ATOM   1496 C CB  . ILE C 2 152 ? -50.906 22.602  -51.888  1.00 23.77  ? 164  ILE B CB  1 
ATOM   1497 C CG1 . ILE C 2 152 ? -50.407 21.303  -52.516  1.00 30.39  ? 164  ILE B CG1 1 
ATOM   1498 C CG2 . ILE C 2 152 ? -50.373 22.740  -50.469  1.00 22.14  ? 164  ILE B CG2 1 
ATOM   1499 C CD1 . ILE C 2 152 ? -49.074 21.445  -53.188  1.00 58.31  ? 164  ILE B CD1 1 
ATOM   1500 N N   . PRO C 2 153 ? -52.979 25.078  -52.064  1.00 33.51  ? 165  PRO B N   1 
ATOM   1501 C CA  . PRO C 2 153 ? -53.631 26.282  -51.523  1.00 26.03  ? 165  PRO B CA  1 
ATOM   1502 C C   . PRO C 2 153 ? -55.119 26.105  -51.298  1.00 29.02  ? 165  PRO B C   1 
ATOM   1503 O O   . PRO C 2 153 ? -55.687 26.759  -50.413  1.00 34.81  ? 165  PRO B O   1 
ATOM   1504 C CB  . PRO C 2 153 ? -53.345 27.346  -52.593  1.00 33.04  ? 165  PRO B CB  1 
ATOM   1505 C CG  . PRO C 2 153 ? -52.128 26.854  -53.290  1.00 51.14  ? 165  PRO B CG  1 
ATOM   1506 C CD  . PRO C 2 153 ? -52.297 25.372  -53.340  1.00 43.21  ? 165  PRO B CD  1 
ATOM   1507 N N   . LEU C 2 154 ? -55.768 25.230  -52.069  1.00 32.29  ? 166  LEU B N   1 
ATOM   1508 C CA  . LEU C 2 154 ? -57.185 24.962  -51.855  1.00 31.30  ? 166  LEU B CA  1 
ATOM   1509 C C   . LEU C 2 154 ? -57.413 24.149  -50.586  1.00 32.72  ? 166  LEU B C   1 
ATOM   1510 O O   . LEU C 2 154 ? -58.373 24.400  -49.848  1.00 41.40  ? 166  LEU B O   1 
ATOM   1511 C CB  . LEU C 2 154 ? -57.768 24.237  -53.066  1.00 41.09  ? 166  LEU B CB  1 
ATOM   1512 C CG  . LEU C 2 154 ? -58.771 25.022  -53.906  1.00 37.07  ? 166  LEU B CG  1 
ATOM   1513 C CD1 . LEU C 2 154 ? -58.142 26.300  -54.445  1.00 54.49  ? 166  LEU B CD1 1 
ATOM   1514 C CD2 . LEU C 2 154 ? -59.260 24.148  -55.038  1.00 50.23  ? 166  LEU B CD2 1 
ATOM   1515 N N   . CYS C 2 155 ? -56.550 23.164  -50.319  1.00 32.05  ? 167  CYS B N   1 
ATOM   1516 C CA  . CYS C 2 155 ? -56.684 22.382  -49.092  1.00 31.09  ? 167  CYS B CA  1 
ATOM   1517 C C   . CYS C 2 155 ? -56.502 23.259  -47.865  1.00 32.00  ? 167  CYS B C   1 
ATOM   1518 O O   . CYS C 2 155 ? -57.359 23.286  -46.973  1.00 41.74  ? 167  CYS B O   1 
ATOM   1519 C CB  . CYS C 2 155 ? -55.673 21.235  -49.068  1.00 28.63  ? 167  CYS B CB  1 
ATOM   1520 S SG  . CYS C 2 155 ? -55.756 20.107  -50.465  1.00 35.47  ? 167  CYS B SG  1 
ATOM   1521 N N   . LEU C 2 156 ? -55.389 23.997  -47.816  1.00 27.95  ? 168  LEU B N   1 
ATOM   1522 C CA  . LEU C 2 156 ? -55.052 24.808  -46.650  1.00 23.96  ? 168  LEU B CA  1 
ATOM   1523 C C   . LEU C 2 156 ? -56.224 25.683  -46.216  1.00 31.25  ? 168  LEU B C   1 
ATOM   1524 O O   . LEU C 2 156 ? -56.445 25.892  -45.018  1.00 45.15  ? 168  LEU B O   1 
ATOM   1525 C CB  . LEU C 2 156 ? -53.824 25.662  -46.968  1.00 27.14  ? 168  LEU B CB  1 
ATOM   1526 C CG  . LEU C 2 156 ? -52.428 25.053  -46.756  1.00 29.39  ? 168  LEU B CG  1 
ATOM   1527 C CD1 . LEU C 2 156 ? -52.293 23.639  -47.319  1.00 39.73  ? 168  LEU B CD1 1 
ATOM   1528 C CD2 . LEU C 2 156 ? -51.355 25.968  -47.333  1.00 33.42  ? 168  LEU B CD2 1 
ATOM   1529 N N   . ARG C 2 157 ? -56.992 26.197  -47.182  1.00 45.23  ? 169  ARG B N   1 
ATOM   1530 C CA  . ARG C 2 157 ? -58.203 26.943  -46.854  1.00 32.16  ? 169  ARG B CA  1 
ATOM   1531 C C   . ARG C 2 157 ? -59.220 26.054  -46.150  1.00 34.24  ? 169  ARG B C   1 
ATOM   1532 O O   . ARG C 2 157 ? -59.824 26.461  -45.150  1.00 55.38  ? 169  ARG B O   1 
ATOM   1533 C CB  . ARG C 2 157 ? -58.805 27.550  -48.124  1.00 47.04  ? 169  ARG B CB  1 
ATOM   1534 C CG  . ARG C 2 157 ? -60.331 27.552  -48.167  1.00 54.75  ? 169  ARG B CG  1 
ATOM   1535 C CD  . ARG C 2 157 ? -60.852 28.008  -49.524  1.00 47.33  ? 169  ARG B CD  1 
ATOM   1536 N NE  . ARG C 2 157 ? -60.145 29.187  -50.009  1.00 75.84  ? 169  ARG B NE  1 
ATOM   1537 C CZ  . ARG C 2 157 ? -60.599 30.429  -49.908  1.00 81.06  ? 169  ARG B CZ  1 
ATOM   1538 N NH1 . ARG C 2 157 ? -61.766 30.695  -49.343  1.00 73.30  ? 169  ARG B NH1 1 
ATOM   1539 N NH2 . ARG C 2 157 ? -59.865 31.429  -50.386  1.00 75.69  ? 169  ARG B NH2 1 
ATOM   1540 N N   . ILE C 2 158 ? -59.419 24.833  -46.654  1.00 31.94  ? 170  ILE B N   1 
ATOM   1541 C CA  . ILE C 2 158 ? -60.401 23.940  -46.049  1.00 33.66  ? 170  ILE B CA  1 
ATOM   1542 C C   . ILE C 2 158 ? -59.889 23.414  -44.713  1.00 33.12  ? 170  ILE B C   1 
ATOM   1543 O O   . ILE C 2 158 ? -60.681 23.107  -43.814  1.00 38.29  ? 170  ILE B O   1 
ATOM   1544 C CB  . ILE C 2 158 ? -60.752 22.799  -47.025  1.00 29.12  ? 170  ILE B CB  1 
ATOM   1545 C CG1 . ILE C 2 158 ? -61.896 23.217  -47.942  1.00 35.42  ? 170  ILE B CG1 1 
ATOM   1546 C CG2 . ILE C 2 158 ? -61.194 21.546  -46.286  1.00 26.63  ? 170  ILE B CG2 1 
ATOM   1547 C CD1 . ILE C 2 158 ? -62.143 22.240  -49.073  1.00 26.87  ? 170  ILE B CD1 1 
ATOM   1548 N N   . MET C 2 159 ? -58.567 23.327  -44.541  1.00 37.05  ? 171  MET B N   1 
ATOM   1549 C CA  . MET C 2 159 ? -58.034 22.829  -43.275  1.00 38.57  ? 171  MET B CA  1 
ATOM   1550 C C   . MET C 2 159 ? -58.207 23.851  -42.155  1.00 44.14  ? 171  MET B C   1 
ATOM   1551 O O   . MET C 2 159 ? -58.411 23.474  -40.995  1.00 50.32  ? 171  MET B O   1 
ATOM   1552 C CB  . MET C 2 159 ? -56.566 22.434  -43.432  1.00 31.97  ? 171  MET B CB  1 
ATOM   1553 C CG  . MET C 2 159 ? -56.285 21.656  -44.704  1.00 34.75  ? 171  MET B CG  1 
ATOM   1554 S SD  . MET C 2 159 ? -54.929 20.485  -44.563  1.00 34.27  ? 171  MET B SD  1 
ATOM   1555 C CE  . MET C 2 159 ? -53.627 21.546  -43.962  1.00 35.30  ? 171  MET B CE  1 
ATOM   1556 N N   . GLU C 2 160 ? -58.133 25.148  -42.473  1.00 37.92  ? 172  GLU B N   1 
ATOM   1557 C CA  A GLU C 2 160 ? -58.370 26.176  -41.463  0.39 39.08  ? 172  GLU B CA  1 
ATOM   1558 C CA  B GLU C 2 160 ? -58.362 26.161  -41.450  0.61 39.05  ? 172  GLU B CA  1 
ATOM   1559 C C   . GLU C 2 160 ? -59.854 26.342  -41.176  1.00 41.42  ? 172  GLU B C   1 
ATOM   1560 O O   . GLU C 2 160 ? -60.275 26.383  -40.015  1.00 67.13  ? 172  GLU B O   1 
ATOM   1561 C CB  A GLU C 2 160 ? -57.810 27.524  -41.901  0.39 38.90  ? 172  GLU B CB  1 
ATOM   1562 C CB  B GLU C 2 160 ? -57.706 27.477  -41.874  0.61 38.72  ? 172  GLU B CB  1 
ATOM   1563 C CG  A GLU C 2 160 ? -56.358 27.764  -41.608  0.39 39.78  ? 172  GLU B CG  1 
ATOM   1564 C CG  B GLU C 2 160 ? -58.279 28.713  -41.211  0.61 34.14  ? 172  GLU B CG  1 
ATOM   1565 C CD  A GLU C 2 160 ? -55.934 29.130  -42.086  0.39 45.40  ? 172  GLU B CD  1 
ATOM   1566 C CD  B GLU C 2 160 ? -58.876 29.671  -42.220  0.61 50.63  ? 172  GLU B CD  1 
ATOM   1567 O OE1 A GLU C 2 160 ? -56.726 29.770  -42.802  0.39 44.44  ? 172  GLU B OE1 1 
ATOM   1568 O OE1 B GLU C 2 160 ? -58.469 29.612  -43.400  0.61 46.35  ? 172  GLU B OE1 1 
ATOM   1569 O OE2 A GLU C 2 160 ? -54.823 29.569  -41.759  0.39 53.91  ? 172  GLU B OE2 1 
ATOM   1570 O OE2 B GLU C 2 160 ? -59.742 30.486  -41.838  0.61 53.47  ? 172  GLU B OE2 1 
ATOM   1571 N N   . SER C 2 161 ? -60.658 26.459  -42.224  1.00 33.72  ? 173  SER B N   1 
ATOM   1572 C CA  . SER C 2 161 ? -62.095 26.647  -42.112  1.00 43.75  ? 173  SER B CA  1 
ATOM   1573 C C   . SER C 2 161 ? -62.799 25.287  -42.185  1.00 42.29  ? 173  SER B C   1 
ATOM   1574 O O   . SER C 2 161 ? -62.192 24.244  -41.914  1.00 54.15  ? 173  SER B O   1 
ATOM   1575 C CB  . SER C 2 161 ? -62.553 27.615  -43.209  1.00 56.63  ? 173  SER B CB  1 
ATOM   1576 O OG  . SER C 2 161 ? -63.950 27.848  -43.136  1.00 68.20  ? 173  SER B OG  1 
ATOM   1577 N N   . GLY C 2 162 ? -64.082 25.290  -42.532  1.00 38.33  ? 174  GLY B N   1 
ATOM   1578 C CA  . GLY C 2 162 ? -64.791 24.061  -42.839  1.00 42.35  ? 174  GLY B CA  1 
ATOM   1579 C C   . GLY C 2 162 ? -65.007 23.149  -41.640  1.00 41.35  ? 174  GLY B C   1 
ATOM   1580 O O   . GLY C 2 162 ? -64.607 23.424  -40.509  1.00 59.13  ? 174  GLY B O   1 
ATOM   1581 N N   . SER C 2 163 ? -65.658 22.022  -41.921  1.00 40.37  ? 175  SER B N   1 
ATOM   1582 C CA  . SER C 2 163 ? -66.016 21.034  -40.916  1.00 27.40  ? 175  SER B CA  1 
ATOM   1583 C C   . SER C 2 163 ? -64.802 20.199  -40.514  1.00 32.41  ? 175  SER B C   1 
ATOM   1584 O O   . SER C 2 163 ? -63.730 20.273  -41.119  1.00 39.17  ? 175  SER B O   1 
ATOM   1585 C CB  . SER C 2 163 ? -67.128 20.125  -41.440  1.00 46.46  ? 175  SER B CB  1 
ATOM   1586 O OG  . SER C 2 163 ? -66.633 19.227  -42.422  1.00 44.96  ? 175  SER B OG  1 
ATOM   1587 N N   . GLU C 2 164 ? -64.988 19.384  -39.472  1.00 35.75  ? 176  GLU B N   1 
ATOM   1588 C CA  . GLU C 2 164 ? -63.925 18.483  -39.039  1.00 34.38  ? 176  GLU B CA  1 
ATOM   1589 C C   . GLU C 2 164 ? -63.672 17.396  -40.075  1.00 36.24  ? 176  GLU B C   1 
ATOM   1590 O O   . GLU C 2 164 ? -62.516 17.079  -40.382  1.00 39.84  ? 176  GLU B O   1 
ATOM   1591 C CB  . GLU C 2 164 ? -64.278 17.858  -37.691  1.00 51.56  ? 176  GLU B CB  1 
ATOM   1592 C CG  . GLU C 2 164 ? -63.349 16.732  -37.265  1.00 32.58  ? 176  GLU B CG  1 
ATOM   1593 C CD  . GLU C 2 164 ? -63.990 15.364  -37.395  1.00 42.60  ? 176  GLU B CD  1 
ATOM   1594 O OE1 . GLU C 2 164 ? -65.006 15.247  -38.115  1.00 42.52  ? 176  GLU B OE1 1 
ATOM   1595 O OE2 . GLU C 2 164 ? -63.482 14.408  -36.768  1.00 51.19  ? 176  GLU B OE2 1 
ATOM   1596 N N   . LEU C 2 165 ? -64.743 16.809  -40.615  1.00 30.25  ? 177  LEU B N   1 
ATOM   1597 C CA  . LEU C 2 165 ? -64.589 15.828  -41.683  1.00 23.52  ? 177  LEU B CA  1 
ATOM   1598 C C   . LEU C 2 165 ? -63.868 16.436  -42.879  1.00 32.52  ? 177  LEU B C   1 
ATOM   1599 O O   . LEU C 2 165 ? -62.897 15.866  -43.389  1.00 31.28  ? 177  LEU B O   1 
ATOM   1600 C CB  . LEU C 2 165 ? -65.957 15.286  -42.093  1.00 26.86  ? 177  LEU B CB  1 
ATOM   1601 C CG  . LEU C 2 165 ? -65.947 14.161  -43.128  1.00 24.47  ? 177  LEU B CG  1 
ATOM   1602 C CD1 . LEU C 2 165 ? -65.181 12.957  -42.603  1.00 27.13  ? 177  LEU B CD1 1 
ATOM   1603 C CD2 . LEU C 2 165 ? -67.367 13.781  -43.498  1.00 26.52  ? 177  LEU B CD2 1 
ATOM   1604 N N   . SER C 2 166 ? -64.327 17.607  -43.333  1.00 38.34  ? 178  SER B N   1 
ATOM   1605 C CA  . SER C 2 166 ? -63.652 18.292  -44.431  1.00 29.35  ? 178  SER B CA  1 
ATOM   1606 C C   . SER C 2 166 ? -62.205 18.597  -44.076  1.00 26.51  ? 178  SER B C   1 
ATOM   1607 O O   . SER C 2 166 ? -61.310 18.471  -44.921  1.00 28.68  ? 178  SER B O   1 
ATOM   1608 C CB  . SER C 2 166 ? -64.394 19.581  -44.785  1.00 26.20  ? 178  SER B CB  1 
ATOM   1609 O OG  . SER C 2 166 ? -65.695 19.305  -45.269  1.00 43.47  ? 178  SER B OG  1 
ATOM   1610 N N   . LYS C 2 167 ? -61.957 19.002  -42.829  1.00 17.91  ? 179  LYS B N   1 
ATOM   1611 C CA  . LYS C 2 167 ? -60.589 19.258  -42.396  1.00 22.05  ? 179  LYS B CA  1 
ATOM   1612 C C   . LYS C 2 167 ? -59.752 17.989  -42.469  1.00 25.58  ? 179  LYS B C   1 
ATOM   1613 O O   . LYS C 2 167 ? -58.604 18.017  -42.926  1.00 41.22  ? 179  LYS B O   1 
ATOM   1614 C CB  . LYS C 2 167 ? -60.582 19.822  -40.974  1.00 29.94  ? 179  LYS B CB  1 
ATOM   1615 C CG  . LYS C 2 167 ? -60.813 21.330  -40.880  1.00 25.63  ? 179  LYS B CG  1 
ATOM   1616 C CD  . LYS C 2 167 ? -60.669 21.823  -39.444  1.00 18.34  ? 179  LYS B CD  1 
ATOM   1617 C CE  . LYS C 2 167 ? -61.736 22.843  -39.080  1.00 17.94  ? 179  LYS B CE  1 
ATOM   1618 N NZ  . LYS C 2 167 ? -61.684 23.215  -37.633  1.00 38.03  ? 179  LYS B NZ  1 
ATOM   1619 N N   . THR C 2 168 ? -60.318 16.863  -42.034  1.00 21.88  ? 180  THR B N   1 
ATOM   1620 C CA  . THR C 2 168 ? -59.572 15.611  -42.041  1.00 23.70  ? 180  THR B CA  1 
ATOM   1621 C C   . THR C 2 168 ? -59.217 15.191  -43.462  1.00 31.15  ? 180  THR B C   1 
ATOM   1622 O O   . THR C 2 168 ? -58.044 14.945  -43.774  1.00 31.45  ? 180  THR B O   1 
ATOM   1623 C CB  . THR C 2 168 ? -60.378 14.519  -41.335  1.00 25.42  ? 180  THR B CB  1 
ATOM   1624 O OG1 . THR C 2 168 ? -60.429 14.794  -39.927  1.00 27.51  ? 180  THR B OG1 1 
ATOM   1625 C CG2 . THR C 2 168 ? -59.737 13.159  -41.557  1.00 32.00  ? 180  THR B CG2 1 
ATOM   1626 N N   . VAL C 2 169 ? -60.218 15.119  -44.345  1.00 25.75  ? 181  VAL B N   1 
ATOM   1627 C CA  . VAL C 2 169 ? -59.982 14.647  -45.707  1.00 24.90  ? 181  VAL B CA  1 
ATOM   1628 C C   . VAL C 2 169 ? -58.983 15.545  -46.424  1.00 30.32  ? 181  VAL B C   1 
ATOM   1629 O O   . VAL C 2 169 ? -58.110 15.064  -47.158  1.00 29.64  ? 181  VAL B O   1 
ATOM   1630 C CB  . VAL C 2 169 ? -61.311 14.551  -46.480  1.00 14.70  ? 181  VAL B CB  1 
ATOM   1631 C CG1 . VAL C 2 169 ? -61.076 13.977  -47.863  1.00 14.72  ? 181  VAL B CG1 1 
ATOM   1632 C CG2 . VAL C 2 169 ? -62.301 13.693  -45.716  1.00 21.48  ? 181  VAL B CG2 1 
ATOM   1633 N N   . ALA C 2 170 ? -59.087 16.861  -46.217  1.00 27.33  ? 182  ALA B N   1 
ATOM   1634 C CA  . ALA C 2 170 ? -58.136 17.783  -46.831  1.00 23.29  ? 182  ALA B CA  1 
ATOM   1635 C C   . ALA C 2 170 ? -56.725 17.534  -46.317  1.00 22.90  ? 182  ALA B C   1 
ATOM   1636 O O   . ALA C 2 170 ? -55.765 17.489  -47.096  1.00 21.66  ? 182  ALA B O   1 
ATOM   1637 C CB  . ALA C 2 170 ? -58.555 19.226  -46.565  1.00 23.78  ? 182  ALA B CB  1 
ATOM   1638 N N   . THR C 2 171 ? -56.577 17.372  -45.001  1.00 17.05  ? 183  THR B N   1 
ATOM   1639 C CA  . THR C 2 171 ? -55.256 17.082  -44.461  1.00 20.20  ? 183  THR B CA  1 
ATOM   1640 C C   . THR C 2 171 ? -54.736 15.749  -44.982  1.00 27.31  ? 183  THR B C   1 
ATOM   1641 O O   . THR C 2 171 ? -53.549 15.626  -45.310  1.00 27.47  ? 183  THR B O   1 
ATOM   1642 C CB  . THR C 2 171 ? -55.292 17.103  -42.937  1.00 14.34  ? 183  THR B CB  1 
ATOM   1643 O OG1 . THR C 2 171 ? -55.977 18.281  -42.498  1.00 14.67  ? 183  THR B OG1 1 
ATOM   1644 C CG2 . THR C 2 171 ? -53.879 17.114  -42.380  1.00 20.36  ? 183  THR B CG2 1 
ATOM   1645 N N   . PHE C 2 172 ? -55.616 14.749  -45.095  1.00 25.60  ? 184  PHE B N   1 
ATOM   1646 C CA  . PHE C 2 172 ? -55.204 13.465  -45.654  1.00 22.60  ? 184  PHE B CA  1 
ATOM   1647 C C   . PHE C 2 172 ? -54.677 13.629  -47.073  1.00 25.08  ? 184  PHE B C   1 
ATOM   1648 O O   . PHE C 2 172 ? -53.676 13.005  -47.448  1.00 27.84  ? 184  PHE B O   1 
ATOM   1649 C CB  . PHE C 2 172 ? -56.370 12.478  -45.632  1.00 18.39  ? 184  PHE B CB  1 
ATOM   1650 C CG  . PHE C 2 172 ? -56.124 11.241  -46.445  1.00 19.01  ? 184  PHE B CG  1 
ATOM   1651 C CD1 . PHE C 2 172 ? -55.116 10.355  -46.097  1.00 27.42  ? 184  PHE B CD1 1 
ATOM   1652 C CD2 . PHE C 2 172 ? -56.890 10.970  -47.568  1.00 26.44  ? 184  PHE B CD2 1 
ATOM   1653 C CE1 . PHE C 2 172 ? -54.882 9.216   -46.850  1.00 43.59  ? 184  PHE B CE1 1 
ATOM   1654 C CE2 . PHE C 2 172 ? -56.660 9.835   -48.327  1.00 26.35  ? 184  PHE B CE2 1 
ATOM   1655 C CZ  . PHE C 2 172 ? -55.655 8.956   -47.967  1.00 31.37  ? 184  PHE B CZ  1 
ATOM   1656 N N   . ILE C 2 173 ? -55.339 14.463  -47.876  1.00 22.75  ? 185  ILE B N   1 
ATOM   1657 C CA  . ILE C 2 173 ? -54.858 14.724  -49.229  1.00 16.08  ? 185  ILE B CA  1 
ATOM   1658 C C   . ILE C 2 173 ? -53.495 15.397  -49.179  1.00 20.87  ? 185  ILE B C   1 
ATOM   1659 O O   . ILE C 2 173 ? -52.559 15.002  -49.886  1.00 27.90  ? 185  ILE B O   1 
ATOM   1660 C CB  . ILE C 2 173 ? -55.877 15.572  -50.009  1.00 14.20  ? 185  ILE B CB  1 
ATOM   1661 C CG1 . ILE C 2 173 ? -57.189 14.805  -50.164  1.00 17.78  ? 185  ILE B CG1 1 
ATOM   1662 C CG2 . ILE C 2 173 ? -55.318 15.946  -51.374  1.00 12.32  ? 185  ILE B CG2 1 
ATOM   1663 C CD1 . ILE C 2 173 ? -58.373 15.683  -50.489  1.00 26.31  ? 185  ILE B CD1 1 
ATOM   1664 N N   . LEU C 2 174 ? -53.361 16.426  -48.339  1.00 20.09  ? 186  LEU B N   1 
ATOM   1665 C CA  . LEU C 2 174 ? -52.062 17.062  -48.164  1.00 19.10  ? 186  LEU B CA  1 
ATOM   1666 C C   . LEU C 2 174 ? -51.039 16.057  -47.661  1.00 22.85  ? 186  LEU B C   1 
ATOM   1667 O O   . LEU C 2 174 ? -49.915 15.985  -48.174  1.00 23.22  ? 186  LEU B O   1 
ATOM   1668 C CB  . LEU C 2 174 ? -52.174 18.242  -47.200  1.00 15.27  ? 186  LEU B CB  1 
ATOM   1669 C CG  . LEU C 2 174 ? -50.839 18.790  -46.687  1.00 11.00  ? 186  LEU B CG  1 
ATOM   1670 C CD1 . LEU C 2 174 ? -49.952 19.277  -47.828  1.00 9.40   ? 186  LEU B CD1 1 
ATOM   1671 C CD2 . LEU C 2 174 ? -51.075 19.900  -45.689  1.00 8.66   ? 186  LEU B CD2 1 
ATOM   1672 N N   . GLN C 2 175 ? -51.426 15.259  -46.663  1.00 26.89  ? 187  GLN B N   1 
ATOM   1673 C CA  . GLN C 2 175 ? -50.542 14.231  -46.123  1.00 20.60  ? 187  GLN B CA  1 
ATOM   1674 C C   . GLN C 2 175 ? -50.015 13.317  -47.224  1.00 27.06  ? 187  GLN B C   1 
ATOM   1675 O O   . GLN C 2 175 ? -48.802 13.121  -47.358  1.00 24.96  ? 187  GLN B O   1 
ATOM   1676 C CB  . GLN C 2 175 ? -51.290 13.426  -45.060  1.00 12.95  ? 187  GLN B CB  1 
ATOM   1677 C CG  . GLN C 2 175 ? -50.673 12.089  -44.727  1.00 19.35  ? 187  GLN B CG  1 
ATOM   1678 C CD  . GLN C 2 175 ? -51.491 11.321  -43.708  1.00 31.32  ? 187  GLN B CD  1 
ATOM   1679 O OE1 . GLN C 2 175 ? -51.670 11.770  -42.573  1.00 36.22  ? 187  GLN B OE1 1 
ATOM   1680 N NE2 . GLN C 2 175 ? -51.990 10.155  -44.106  1.00 47.95  ? 187  GLN B NE2 1 
ATOM   1681 N N   . LYS C 2 176 ? -50.919 12.768  -48.042  1.00 20.33  ? 188  LYS B N   1 
ATOM   1682 C CA  . LYS C 2 176 ? -50.501 11.837  -49.085  1.00 24.83  ? 188  LYS B CA  1 
ATOM   1683 C C   . LYS C 2 176 ? -49.548 12.489  -50.078  1.00 33.49  ? 188  LYS B C   1 
ATOM   1684 O O   . LYS C 2 176 ? -48.672 11.812  -50.630  1.00 37.57  ? 188  LYS B O   1 
ATOM   1685 C CB  . LYS C 2 176 ? -51.725 11.274  -49.806  1.00 24.41  ? 188  LYS B CB  1 
ATOM   1686 C CG  . LYS C 2 176 ? -52.308 10.041  -49.139  1.00 26.51  ? 188  LYS B CG  1 
ATOM   1687 C CD  . LYS C 2 176 ? -51.300 8.900   -49.137  1.00 32.24  ? 188  LYS B CD  1 
ATOM   1688 C CE  . LYS C 2 176 ? -51.991 7.551   -49.023  1.00 49.02  ? 188  LYS B CE  1 
ATOM   1689 N NZ  . LYS C 2 176 ? -51.445 6.570   -50.004  1.00 53.20  ? 188  LYS B NZ  1 
ATOM   1690 N N   . ILE C 2 177 ? -49.695 13.794  -50.315  1.00 30.65  ? 189  ILE B N   1 
ATOM   1691 C CA  . ILE C 2 177 ? -48.750 14.498  -51.178  1.00 25.11  ? 189  ILE B CA  1 
ATOM   1692 C C   . ILE C 2 177 ? -47.386 14.590  -50.509  1.00 35.13  ? 189  ILE B C   1 
ATOM   1693 O O   . ILE C 2 177 ? -46.345 14.417  -51.156  1.00 33.68  ? 189  ILE B O   1 
ATOM   1694 C CB  . ILE C 2 177 ? -49.292 15.891  -51.541  1.00 18.12  ? 189  ILE B CB  1 
ATOM   1695 C CG1 . ILE C 2 177 ? -50.604 15.768  -52.319  1.00 27.03  ? 189  ILE B CG1 1 
ATOM   1696 C CG2 . ILE C 2 177 ? -48.257 16.670  -52.340  1.00 20.72  ? 189  ILE B CG2 1 
ATOM   1697 C CD1 . ILE C 2 177 ? -51.207 17.100  -52.717  1.00 17.43  ? 189  ILE B CD1 1 
ATOM   1698 N N   . LEU C 2 178 ? -47.367 14.863  -49.203  1.00 28.27  ? 190  LEU B N   1 
ATOM   1699 C CA  . LEU C 2 178 ? -46.104 14.960  -48.482  1.00 24.93  ? 190  LEU B CA  1 
ATOM   1700 C C   . LEU C 2 178 ? -45.398 13.612  -48.415  1.00 38.39  ? 190  LEU B C   1 
ATOM   1701 O O   . LEU C 2 178 ? -44.166 13.548  -48.512  1.00 42.06  ? 190  LEU B O   1 
ATOM   1702 C CB  . LEU C 2 178 ? -46.348 15.509  -47.079  1.00 19.95  ? 190  LEU B CB  1 
ATOM   1703 C CG  . LEU C 2 178 ? -46.815 16.962  -47.034  1.00 21.33  ? 190  LEU B CG  1 
ATOM   1704 C CD1 . LEU C 2 178 ? -47.350 17.328  -45.657  1.00 12.53  ? 190  LEU B CD1 1 
ATOM   1705 C CD2 . LEU C 2 178 ? -45.669 17.869  -47.430  1.00 27.35  ? 190  LEU B CD2 1 
ATOM   1706 N N   . LEU C 2 179 ? -46.163 12.527  -48.240  1.00 40.86  ? 191  LEU B N   1 
ATOM   1707 C CA  . LEU C 2 179 ? -45.579 11.188  -48.213  1.00 36.69  ? 191  LEU B CA  1 
ATOM   1708 C C   . LEU C 2 179 ? -44.715 10.929  -49.438  1.00 40.63  ? 191  LEU B C   1 
ATOM   1709 O O   . LEU C 2 179 ? -43.653 10.305  -49.338  1.00 51.40  ? 191  LEU B O   1 
ATOM   1710 C CB  . LEU C 2 179 ? -46.683 10.135  -48.101  1.00 40.33  ? 191  LEU B CB  1 
ATOM   1711 C CG  . LEU C 2 179 ? -47.027 9.635   -46.694  1.00 51.65  ? 191  LEU B CG  1 
ATOM   1712 C CD1 . LEU C 2 179 ? -47.528 10.755  -45.805  1.00 32.49  ? 191  LEU B CD1 1 
ATOM   1713 C CD2 . LEU C 2 179 ? -48.066 8.522   -46.779  1.00 65.93  ? 191  LEU B CD2 1 
ATOM   1714 N N   . ASP C 2 180 ? -45.150 11.404  -50.602  1.00 42.55  ? 192  ASP B N   1 
ATOM   1715 C CA  . ASP C 2 180 ? -44.316 11.330  -51.791  1.00 50.44  ? 192  ASP B CA  1 
ATOM   1716 C C   . ASP C 2 180 ? -43.144 12.294  -51.667  1.00 48.18  ? 192  ASP B C   1 
ATOM   1717 O O   . ASP C 2 180 ? -43.303 13.438  -51.228  1.00 41.63  ? 192  ASP B O   1 
ATOM   1718 C CB  . ASP C 2 180 ? -45.132 11.651  -53.040  1.00 55.35  ? 192  ASP B CB  1 
ATOM   1719 C CG  . ASP C 2 180 ? -44.656 10.887  -54.260  1.00 66.08  ? 192  ASP B CG  1 
ATOM   1720 O OD1 . ASP C 2 180 ? -45.073 9.721   -54.438  1.00 71.57  ? 192  ASP B OD1 1 
ATOM   1721 O OD2 . ASP C 2 180 ? -43.862 11.455  -55.042  1.00 58.74  ? 192  ASP B OD2 1 
ATOM   1722 N N   . ASP C 2 181 ? -41.955 11.819  -52.050  1.00 48.06  ? 193  ASP B N   1 
ATOM   1723 C CA  . ASP C 2 181 ? -40.767 12.662  -51.980  1.00 36.07  ? 193  ASP B CA  1 
ATOM   1724 C C   . ASP C 2 181 ? -40.937 13.919  -52.823  1.00 38.88  ? 193  ASP B C   1 
ATOM   1725 O O   . ASP C 2 181 ? -40.537 15.013  -52.407  1.00 43.25  ? 193  ASP B O   1 
ATOM   1726 C CB  . ASP C 2 181 ? -39.535 11.878  -52.433  1.00 37.73  ? 193  ASP B CB  1 
ATOM   1727 C CG  . ASP C 2 181 ? -39.162 10.765  -51.472  1.00 57.07  ? 193  ASP B CG  1 
ATOM   1728 O OD1 . ASP C 2 181 ? -39.224 10.991  -50.244  1.00 56.53  ? 193  ASP B OD1 1 
ATOM   1729 O OD2 . ASP C 2 181 ? -38.799 9.666   -51.946  1.00 55.92  ? 193  ASP B OD2 1 
ATOM   1730 N N   . THR C 2 182 ? -41.541 13.781  -54.006  1.00 32.14  ? 194  THR B N   1 
ATOM   1731 C CA  . THR C 2 182 ? -41.710 14.931  -54.888  1.00 27.30  ? 194  THR B CA  1 
ATOM   1732 C C   . THR C 2 182 ? -42.620 15.976  -54.259  1.00 38.90  ? 194  THR B C   1 
ATOM   1733 O O   . THR C 2 182 ? -42.409 17.182  -54.437  1.00 43.39  ? 194  THR B O   1 
ATOM   1734 C CB  . THR C 2 182 ? -42.270 14.485  -56.236  1.00 32.00  ? 194  THR B CB  1 
ATOM   1735 O OG1 . THR C 2 182 ? -41.651 13.255  -56.630  1.00 42.67  ? 194  THR B OG1 1 
ATOM   1736 C CG2 . THR C 2 182 ? -42.001 15.544  -57.293  1.00 36.34  ? 194  THR B CG2 1 
ATOM   1737 N N   . GLY C 2 183 ? -43.640 15.533  -53.522  1.00 43.58  ? 195  GLY B N   1 
ATOM   1738 C CA  . GLY C 2 183 ? -44.511 16.479  -52.846  1.00 33.12  ? 195  GLY B CA  1 
ATOM   1739 C C   . GLY C 2 183 ? -43.786 17.253  -51.765  1.00 40.03  ? 195  GLY B C   1 
ATOM   1740 O O   . GLY C 2 183 ? -44.010 18.454  -51.589  1.00 44.39  ? 195  GLY B O   1 
ATOM   1741 N N   . LEU C 2 184 ? -42.900 16.578  -51.030  1.00 45.53  ? 196  LEU B N   1 
ATOM   1742 C CA  . LEU C 2 184 ? -42.109 17.257  -50.010  1.00 32.90  ? 196  LEU B CA  1 
ATOM   1743 C C   . LEU C 2 184 ? -41.183 18.293  -50.629  1.00 36.69  ? 196  LEU B C   1 
ATOM   1744 O O   . LEU C 2 184 ? -41.153 19.452  -50.199  1.00 42.50  ? 196  LEU B O   1 
ATOM   1745 C CB  . LEU C 2 184 ? -41.293 16.243  -49.216  1.00 34.28  ? 196  LEU B CB  1 
ATOM   1746 C CG  . LEU C 2 184 ? -40.817 16.744  -47.854  1.00 32.37  ? 196  LEU B CG  1 
ATOM   1747 C CD1 . LEU C 2 184 ? -41.811 17.724  -47.227  1.00 43.40  ? 196  LEU B CD1 1 
ATOM   1748 C CD2 . LEU C 2 184 ? -40.536 15.582  -46.942  1.00 38.77  ? 196  LEU B CD2 1 
ATOM   1749 N N   . ALA C 2 185 ? -40.403 17.881  -51.632  1.00 36.78  ? 197  ALA B N   1 
ATOM   1750 C CA  . ALA C 2 185 ? -39.431 18.783  -52.240  1.00 29.64  ? 197  ALA B CA  1 
ATOM   1751 C C   . ALA C 2 185 ? -40.106 20.030  -52.794  1.00 44.74  ? 197  ALA B C   1 
ATOM   1752 O O   . ALA C 2 185 ? -39.544 21.131  -52.730  1.00 53.03  ? 197  ALA B O   1 
ATOM   1753 C CB  . ALA C 2 185 ? -38.661 18.055  -53.341  1.00 25.94  ? 197  ALA B CB  1 
ATOM   1754 N N   . TYR C 2 186 ? -41.316 19.877  -53.333  1.00 46.90  ? 198  TYR B N   1 
ATOM   1755 C CA  . TYR C 2 186 ? -42.038 21.022  -53.876  1.00 48.16  ? 198  TYR B CA  1 
ATOM   1756 C C   . TYR C 2 186 ? -42.395 22.018  -52.781  1.00 45.83  ? 198  TYR B C   1 
ATOM   1757 O O   . TYR C 2 186 ? -42.238 23.232  -52.958  1.00 52.54  ? 198  TYR B O   1 
ATOM   1758 C CB  . TYR C 2 186 ? -43.295 20.540  -54.602  1.00 47.37  ? 198  TYR B CB  1 
ATOM   1759 C CG  . TYR C 2 186 ? -44.117 21.629  -55.258  1.00 45.74  ? 198  TYR B CG  1 
ATOM   1760 C CD1 . TYR C 2 186 ? -43.796 22.106  -56.524  1.00 45.37  ? 198  TYR B CD1 1 
ATOM   1761 C CD2 . TYR C 2 186 ? -45.228 22.165  -54.618  1.00 46.29  ? 198  TYR B CD2 1 
ATOM   1762 C CE1 . TYR C 2 186 ? -44.554 23.097  -57.128  1.00 54.04  ? 198  TYR B CE1 1 
ATOM   1763 C CE2 . TYR C 2 186 ? -45.991 23.153  -55.214  1.00 45.31  ? 198  TYR B CE2 1 
ATOM   1764 C CZ  . TYR C 2 186 ? -45.651 23.616  -56.467  1.00 49.91  ? 198  TYR B CZ  1 
ATOM   1765 O OH  . TYR C 2 186 ? -46.414 24.600  -57.055  1.00 56.69  ? 198  TYR B OH  1 
ATOM   1766 N N   . ILE C 2 187 ? -42.860 21.521  -51.633  1.00 36.26  ? 199  ILE B N   1 
ATOM   1767 C CA  . ILE C 2 187 ? -43.356 22.409  -50.588  1.00 42.73  ? 199  ILE B CA  1 
ATOM   1768 C C   . ILE C 2 187 ? -42.207 23.105  -49.869  1.00 44.71  ? 199  ILE B C   1 
ATOM   1769 O O   . ILE C 2 187 ? -42.336 24.262  -49.449  1.00 52.43  ? 199  ILE B O   1 
ATOM   1770 C CB  . ILE C 2 187 ? -44.252 21.618  -49.619  1.00 33.21  ? 199  ILE B CB  1 
ATOM   1771 C CG1 . ILE C 2 187 ? -45.433 21.019  -50.387  1.00 32.34  ? 199  ILE B CG1 1 
ATOM   1772 C CG2 . ILE C 2 187 ? -44.741 22.503  -48.482  1.00 26.13  ? 199  ILE B CG2 1 
ATOM   1773 C CD1 . ILE C 2 187 ? -46.586 20.585  -49.517  1.00 34.86  ? 199  ILE B CD1 1 
ATOM   1774 N N   . CYS C 2 188 ? -41.069 22.433  -49.726  1.00 41.39  ? 200  CYS B N   1 
ATOM   1775 C CA  . CYS C 2 188 ? -39.905 23.012  -49.075  1.00 38.67  ? 200  CYS B CA  1 
ATOM   1776 C C   . CYS C 2 188 ? -38.957 23.697  -50.054  1.00 56.70  ? 200  CYS B C   1 
ATOM   1777 O O   . CYS C 2 188 ? -37.816 23.995  -49.685  1.00 52.07  ? 200  CYS B O   1 
ATOM   1778 C CB  . CYS C 2 188 ? -39.150 21.934  -48.295  1.00 42.96  ? 200  CYS B CB  1 
ATOM   1779 S SG  . CYS C 2 188 ? -40.201 20.900  -47.254  1.00 41.84  ? 200  CYS B SG  1 
ATOM   1780 N N   . GLN C 2 189 ? -39.392 23.947  -51.290  1.00 51.86  ? 201  GLN B N   1 
ATOM   1781 C CA  . GLN C 2 189 ? -38.527 24.640  -52.240  1.00 59.29  ? 201  GLN B CA  1 
ATOM   1782 C C   . GLN C 2 189 ? -38.417 26.120  -51.896  1.00 54.77  ? 201  GLN B C   1 
ATOM   1783 O O   . GLN C 2 189 ? -37.311 26.658  -51.773  1.00 73.45  ? 201  GLN B O   1 
ATOM   1784 C CB  . GLN C 2 189 ? -39.042 24.448  -53.667  1.00 53.61  ? 201  GLN B CB  1 
ATOM   1785 C CG  . GLN C 2 189 ? -38.093 23.659  -54.558  1.00 46.41  ? 201  GLN B CG  1 
ATOM   1786 C CD  . GLN C 2 189 ? -38.795 23.020  -55.741  1.00 59.53  ? 201  GLN B CD  1 
ATOM   1787 O OE1 . GLN C 2 189 ? -39.821 23.514  -56.212  1.00 64.34  ? 201  GLN B OE1 1 
ATOM   1788 N NE2 . GLN C 2 189 ? -38.246 21.912  -56.228  1.00 57.38  ? 201  GLN B NE2 1 
ATOM   1789 N N   . THR C 2 190 ? -39.550 26.792  -51.729  1.00 40.47  ? 202  THR B N   1 
ATOM   1790 C CA  . THR C 2 190 ? -39.575 28.197  -51.355  1.00 55.14  ? 202  THR B CA  1 
ATOM   1791 C C   . THR C 2 190 ? -40.001 28.346  -49.901  1.00 62.03  ? 202  THR B C   1 
ATOM   1792 O O   . THR C 2 190 ? -40.494 27.409  -49.267  1.00 61.48  ? 202  THR B O   1 
ATOM   1793 C CB  . THR C 2 190 ? -40.520 28.994  -52.262  1.00 61.65  ? 202  THR B CB  1 
ATOM   1794 O OG1 . THR C 2 190 ? -41.878 28.670  -51.943  1.00 64.10  ? 202  THR B OG1 1 
ATOM   1795 C CG2 . THR C 2 190 ? -40.255 28.670  -53.722  1.00 62.35  ? 202  THR B CG2 1 
ATOM   1796 N N   . TYR C 2 191 ? -39.804 29.555  -49.376  1.00 68.84  ? 203  TYR B N   1 
ATOM   1797 C CA  . TYR C 2 191 ? -40.227 29.849  -48.014  1.00 54.07  ? 203  TYR B CA  1 
ATOM   1798 C C   . TYR C 2 191 ? -41.710 30.182  -47.957  1.00 56.07  ? 203  TYR B C   1 
ATOM   1799 O O   . TYR C 2 191 ? -42.388 29.835  -46.984  1.00 65.40  ? 203  TYR B O   1 
ATOM   1800 C CB  . TYR C 2 191 ? -39.396 30.999  -47.445  1.00 61.81  ? 203  TYR B CB  1 
ATOM   1801 C CG  . TYR C 2 191 ? -39.911 31.550  -46.133  1.00 85.82  ? 203  TYR B CG  1 
ATOM   1802 C CD1 . TYR C 2 191 ? -40.122 30.718  -45.039  1.00 83.71  ? 203  TYR B CD1 1 
ATOM   1803 C CD2 . TYR C 2 191 ? -40.185 32.904  -45.987  1.00 93.91  ? 203  TYR B CD2 1 
ATOM   1804 C CE1 . TYR C 2 191 ? -40.591 31.221  -43.837  1.00 83.87  ? 203  TYR B CE1 1 
ATOM   1805 C CE2 . TYR C 2 191 ? -40.654 33.416  -44.790  1.00 102.18 ? 203  TYR B CE2 1 
ATOM   1806 C CZ  . TYR C 2 191 ? -40.856 32.571  -43.719  1.00 101.60 ? 203  TYR B CZ  1 
ATOM   1807 O OH  . TYR C 2 191 ? -41.324 33.078  -42.527  1.00 110.64 ? 203  TYR B OH  1 
ATOM   1808 N N   . GLU C 2 192 ? -42.229 30.852  -48.989  1.00 56.78  ? 204  GLU B N   1 
ATOM   1809 C CA  . GLU C 2 192 ? -43.651 31.169  -49.017  1.00 63.34  ? 204  GLU B CA  1 
ATOM   1810 C C   . GLU C 2 192 ? -44.499 29.906  -49.045  1.00 65.49  ? 204  GLU B C   1 
ATOM   1811 O O   . GLU C 2 192 ? -45.610 29.891  -48.500  1.00 63.19  ? 204  GLU B O   1 
ATOM   1812 C CB  . GLU C 2 192 ? -43.967 32.054  -50.223  1.00 58.35  ? 204  GLU B CB  1 
ATOM   1813 C CG  . GLU C 2 192 ? -45.389 32.596  -50.254  1.00 57.42  ? 204  GLU B CG  1 
ATOM   1814 C CD  . GLU C 2 192 ? -45.610 33.582  -51.388  1.00 90.43  ? 204  GLU B CD  1 
ATOM   1815 O OE1 . GLU C 2 192 ? -44.827 34.549  -51.500  1.00 83.22  ? 204  GLU B OE1 1 
ATOM   1816 O OE2 . GLU C 2 192 ? -46.561 33.384  -52.174  1.00 96.31  ? 204  GLU B OE2 1 
ATOM   1817 N N   . ARG C 2 193 ? -43.992 28.836  -49.660  1.00 61.36  ? 205  ARG B N   1 
ATOM   1818 C CA  . ARG C 2 193 ? -44.737 27.583  -49.694  1.00 59.06  ? 205  ARG B CA  1 
ATOM   1819 C C   . ARG C 2 193 ? -44.651 26.848  -48.362  1.00 46.70  ? 205  ARG B C   1 
ATOM   1820 O O   . ARG C 2 193 ? -45.655 26.309  -47.882  1.00 54.00  ? 205  ARG B O   1 
ATOM   1821 C CB  . ARG C 2 193 ? -44.227 26.701  -50.833  1.00 60.75  ? 205  ARG B CB  1 
ATOM   1822 C CG  . ARG C 2 193 ? -44.750 27.106  -52.204  1.00 49.10  ? 205  ARG B CG  1 
ATOM   1823 C CD  . ARG C 2 193 ? -45.162 25.893  -53.014  1.00 39.41  ? 205  ARG B CD  1 
ATOM   1824 N NE  . ARG C 2 193 ? -44.035 25.313  -53.734  1.00 54.38  ? 205  ARG B NE  1 
ATOM   1825 C CZ  . ARG C 2 193 ? -43.594 25.741  -54.909  1.00 60.23  ? 205  ARG B CZ  1 
ATOM   1826 N NH1 . ARG C 2 193 ? -44.171 26.754  -55.537  1.00 64.08  ? 205  ARG B NH1 1 
ATOM   1827 N NH2 . ARG C 2 193 ? -42.551 25.135  -55.471  1.00 58.05  ? 205  ARG B NH2 1 
ATOM   1828 N N   . PHE C 2 194 ? -43.466 26.815  -47.751  1.00 42.08  ? 206  PHE B N   1 
ATOM   1829 C CA  . PHE C 2 194 ? -43.333 26.210  -46.430  1.00 38.39  ? 206  PHE B CA  1 
ATOM   1830 C C   . PHE C 2 194 ? -44.169 26.961  -45.401  1.00 45.33  ? 206  PHE B C   1 
ATOM   1831 O O   . PHE C 2 194 ? -45.042 26.382  -44.745  1.00 41.39  ? 206  PHE B O   1 
ATOM   1832 C CB  . PHE C 2 194 ? -41.855 26.171  -46.019  1.00 36.86  ? 206  PHE B CB  1 
ATOM   1833 C CG  . PHE C 2 194 ? -41.612 25.578  -44.651  1.00 46.41  ? 206  PHE B CG  1 
ATOM   1834 C CD1 . PHE C 2 194 ? -40.965 24.363  -44.520  1.00 56.23  ? 206  PHE B CD1 1 
ATOM   1835 C CD2 . PHE C 2 194 ? -41.986 26.251  -43.496  1.00 51.78  ? 206  PHE B CD2 1 
ATOM   1836 C CE1 . PHE C 2 194 ? -40.736 23.822  -43.271  1.00 45.54  ? 206  PHE B CE1 1 
ATOM   1837 C CE2 . PHE C 2 194 ? -41.757 25.709  -42.250  1.00 63.41  ? 206  PHE B CE2 1 
ATOM   1838 C CZ  . PHE C 2 194 ? -41.126 24.494  -42.139  1.00 46.55  ? 206  PHE B CZ  1 
ATOM   1839 N N   . SER C 2 195 ? -43.896 28.258  -45.237  1.00 52.83  ? 207  SER B N   1 
ATOM   1840 C CA  . SER C 2 195 ? -44.512 29.028  -44.161  1.00 45.77  ? 207  SER B CA  1 
ATOM   1841 C C   . SER C 2 195 ? -46.031 28.997  -44.247  1.00 43.46  ? 207  SER B C   1 
ATOM   1842 O O   . SER C 2 195 ? -46.713 28.913  -43.218  1.00 57.26  ? 207  SER B O   1 
ATOM   1843 C CB  . SER C 2 195 ? -44.000 30.468  -44.194  1.00 60.01  ? 207  SER B CB  1 
ATOM   1844 O OG  . SER C 2 195 ? -44.254 31.070  -45.451  1.00 69.63  ? 207  SER B OG  1 
ATOM   1845 N N   . HIS C 2 196 ? -46.582 29.063  -45.461  1.00 41.45  ? 208  HIS B N   1 
ATOM   1846 C CA  . HIS C 2 196 ? -48.032 28.995  -45.600  1.00 49.21  ? 208  HIS B CA  1 
ATOM   1847 C C   . HIS C 2 196 ? -48.566 27.676  -45.058  1.00 45.40  ? 208  HIS B C   1 
ATOM   1848 O O   . HIS C 2 196 ? -49.596 27.649  -44.378  1.00 50.93  ? 208  HIS B O   1 
ATOM   1849 C CB  . HIS C 2 196 ? -48.435 29.187  -47.064  1.00 52.86  ? 208  HIS B CB  1 
ATOM   1850 C CG  . HIS C 2 196 ? -49.905 29.389  -47.266  1.00 50.68  ? 208  HIS B CG  1 
ATOM   1851 N ND1 . HIS C 2 196 ? -50.508 29.290  -48.502  1.00 58.41  ? 208  HIS B ND1 1 
ATOM   1852 C CD2 . HIS C 2 196 ? -50.894 29.687  -46.389  1.00 43.66  ? 208  HIS B CD2 1 
ATOM   1853 C CE1 . HIS C 2 196 ? -51.804 29.514  -48.378  1.00 47.38  ? 208  HIS B CE1 1 
ATOM   1854 N NE2 . HIS C 2 196 ? -52.065 29.757  -47.106  1.00 51.43  ? 208  HIS B NE2 1 
ATOM   1855 N N   . VAL C 2 197 ? -47.861 26.574  -45.319  1.00 38.01  ? 209  VAL B N   1 
ATOM   1856 C CA  . VAL C 2 197 ? -48.304 25.275  -44.822  1.00 37.21  ? 209  VAL B CA  1 
ATOM   1857 C C   . VAL C 2 197 ? -48.114 25.184  -43.311  1.00 43.03  ? 209  VAL B C   1 
ATOM   1858 O O   . VAL C 2 197 ? -49.019 24.765  -42.580  1.00 45.63  ? 209  VAL B O   1 
ATOM   1859 C CB  . VAL C 2 197 ? -47.565 24.143  -45.557  1.00 26.20  ? 209  VAL B CB  1 
ATOM   1860 C CG1 . VAL C 2 197 ? -47.433 22.916  -44.664  1.00 22.40  ? 209  VAL B CG1 1 
ATOM   1861 C CG2 . VAL C 2 197 ? -48.296 23.789  -46.835  1.00 24.13  ? 209  VAL B CG2 1 
ATOM   1862 N N   . ALA C 2 198 ? -46.937 25.581  -42.819  1.00 44.39  ? 210  ALA B N   1 
ATOM   1863 C CA  . ALA C 2 198 ? -46.638 25.415  -41.400  1.00 29.79  ? 210  ALA B CA  1 
ATOM   1864 C C   . ALA C 2 198 ? -47.562 26.262  -40.532  1.00 25.77  ? 210  ALA B C   1 
ATOM   1865 O O   . ALA C 2 198 ? -48.007 25.815  -39.467  1.00 40.37  ? 210  ALA B O   1 
ATOM   1866 C CB  . ALA C 2 198 ? -45.174 25.759  -41.130  1.00 32.85  ? 210  ALA B CB  1 
ATOM   1867 N N   . MET C 2 199 ? -47.865 27.486  -40.972  1.00 26.27  ? 211  MET B N   1 
ATOM   1868 C CA  . MET C 2 199 ? -48.768 28.343  -40.210  1.00 31.79  ? 211  MET B CA  1 
ATOM   1869 C C   . MET C 2 199 ? -50.178 27.769  -40.195  1.00 39.00  ? 211  MET B C   1 
ATOM   1870 O O   . MET C 2 199 ? -50.881 27.851  -39.179  1.00 34.78  ? 211  MET B O   1 
ATOM   1871 C CB  . MET C 2 199 ? -48.767 29.754  -40.793  1.00 42.22  ? 211  MET B CB  1 
ATOM   1872 C CG  . MET C 2 199 ? -50.103 30.473  -40.704  1.00 54.54  ? 211  MET B CG  1 
ATOM   1873 S SD  . MET C 2 199 ? -50.049 32.090  -41.491  1.00 109.90 ? 211  MET B SD  1 
ATOM   1874 C CE  . MET C 2 199 ? -51.441 32.905  -40.710  1.00 75.31  ? 211  MET B CE  1 
ATOM   1875 N N   . ILE C 2 200 ? -50.607 27.191  -41.320  1.00 40.97  ? 212  ILE B N   1 
ATOM   1876 C CA  . ILE C 2 200 ? -51.868 26.454  -41.364  1.00 29.06  ? 212  ILE B CA  1 
ATOM   1877 C C   . ILE C 2 200 ? -51.874 25.400  -40.264  1.00 43.40  ? 212  ILE B C   1 
ATOM   1878 O O   . ILE C 2 200 ? -52.802 25.313  -39.447  1.00 50.29  ? 212  ILE B O   1 
ATOM   1879 C CB  . ILE C 2 200 ? -52.047 25.782  -42.736  1.00 36.97  ? 212  ILE B CB  1 
ATOM   1880 C CG1 . ILE C 2 200 ? -52.433 26.778  -43.825  1.00 45.24  ? 212  ILE B CG1 1 
ATOM   1881 C CG2 . ILE C 2 200 ? -53.136 24.733  -42.663  1.00 56.51  ? 212  ILE B CG2 1 
ATOM   1882 C CD1 . ILE C 2 200 ? -53.446 27.746  -43.427  1.00 33.09  ? 212  ILE B CD1 1 
ATOM   1883 N N   . LEU C 2 201 ? -50.819 24.575  -40.244  1.00 39.28  ? 213  LEU B N   1 
ATOM   1884 C CA  . LEU C 2 201 ? -50.734 23.461  -39.305  1.00 32.86  ? 213  LEU B CA  1 
ATOM   1885 C C   . LEU C 2 201 ? -50.698 23.953  -37.864  1.00 32.59  ? 213  LEU B C   1 
ATOM   1886 O O   . LEU C 2 201 ? -51.267 23.317  -36.968  1.00 44.05  ? 213  LEU B O   1 
ATOM   1887 C CB  . LEU C 2 201 ? -49.491 22.632  -39.615  1.00 28.38  ? 213  LEU B CB  1 
ATOM   1888 C CG  . LEU C 2 201 ? -49.448 21.919  -40.970  1.00 28.48  ? 213  LEU B CG  1 
ATOM   1889 C CD1 . LEU C 2 201 ? -48.034 21.464  -41.266  1.00 31.41  ? 213  LEU B CD1 1 
ATOM   1890 C CD2 . LEU C 2 201 ? -50.397 20.738  -41.020  1.00 26.86  ? 213  LEU B CD2 1 
ATOM   1891 N N   . GLY C 2 202 ? -50.019 25.076  -37.616  1.00 40.90  ? 214  GLY B N   1 
ATOM   1892 C CA  . GLY C 2 202 ? -49.979 25.619  -36.266  1.00 41.03  ? 214  GLY B CA  1 
ATOM   1893 C C   . GLY C 2 202 ? -51.334 26.125  -35.805  1.00 32.47  ? 214  GLY B C   1 
ATOM   1894 O O   . GLY C 2 202 ? -51.770 25.837  -34.687  1.00 36.80  ? 214  GLY B O   1 
ATOM   1895 N N   . LYS C 2 203 ? -52.017 26.889  -36.662  1.00 32.53  ? 215  LYS B N   1 
ATOM   1896 C CA  . LYS C 2 203 ? -53.354 27.369  -36.325  1.00 37.54  ? 215  LYS B CA  1 
ATOM   1897 C C   . LYS C 2 203 ? -54.333 26.220  -36.137  1.00 35.73  ? 215  LYS B C   1 
ATOM   1898 O O   . LYS C 2 203 ? -55.293 26.341  -35.366  1.00 46.50  ? 215  LYS B O   1 
ATOM   1899 C CB  . LYS C 2 203 ? -53.860 28.331  -37.399  1.00 42.16  ? 215  LYS B CB  1 
ATOM   1900 C CG  . LYS C 2 203 ? -53.113 29.649  -37.434  1.00 57.26  ? 215  LYS B CG  1 
ATOM   1901 C CD  . LYS C 2 203 ? -54.033 30.790  -37.820  1.00 56.17  ? 215  LYS B CD  1 
ATOM   1902 C CE  . LYS C 2 203 ? -54.069 30.955  -39.315  1.00 44.88  ? 215  LYS B CE  1 
ATOM   1903 N NZ  . LYS C 2 203 ? -55.281 31.682  -39.798  1.00 65.15  ? 215  LYS B NZ  1 
ATOM   1904 N N   . MET C 2 204 ? -54.111 25.099  -36.826  1.00 30.54  ? 216  MET B N   1 
ATOM   1905 C CA  . MET C 2 204 ? -54.952 23.928  -36.614  1.00 34.07  ? 216  MET B CA  1 
ATOM   1906 C C   . MET C 2 204 ? -54.709 23.306  -35.246  1.00 36.97  ? 216  MET B C   1 
ATOM   1907 O O   . MET C 2 204 ? -55.641 22.769  -34.637  1.00 39.66  ? 216  MET B O   1 
ATOM   1908 C CB  . MET C 2 204 ? -54.706 22.908  -37.720  1.00 40.75  ? 216  MET B CB  1 
ATOM   1909 C CG  . MET C 2 204 ? -55.572 23.111  -38.950  1.00 48.83  ? 216  MET B CG  1 
ATOM   1910 S SD  . MET C 2 204 ? -55.496 21.698  -40.062  1.00 50.48  ? 216  MET B SD  1 
ATOM   1911 C CE  . MET C 2 204 ? -53.733 21.410  -40.082  1.00 25.91  ? 216  MET B CE  1 
ATOM   1912 N N   . VAL C 2 205 ? -53.475 23.378  -34.744  1.00 37.35  ? 217  VAL B N   1 
ATOM   1913 C CA  . VAL C 2 205 ? -53.165 22.794  -33.441  1.00 32.44  ? 217  VAL B CA  1 
ATOM   1914 C C   . VAL C 2 205 ? -53.920 23.530  -32.340  1.00 32.91  ? 217  VAL B C   1 
ATOM   1915 O O   . VAL C 2 205 ? -54.540 22.910  -31.467  1.00 35.85  ? 217  VAL B O   1 
ATOM   1916 C CB  . VAL C 2 205 ? -51.644 22.808  -33.196  1.00 31.65  ? 217  VAL B CB  1 
ATOM   1917 C CG1 . VAL C 2 205 ? -51.344 22.832  -31.706  1.00 35.56  ? 217  VAL B CG1 1 
ATOM   1918 C CG2 . VAL C 2 205 ? -50.985 21.613  -33.868  1.00 26.96  ? 217  VAL B CG2 1 
ATOM   1919 N N   . LEU C 2 206 ? -53.883 24.867  -32.368  1.00 41.79  ? 218  LEU B N   1 
ATOM   1920 C CA  . LEU C 2 206 ? -54.621 25.651  -31.381  1.00 43.25  ? 218  LEU B CA  1 
ATOM   1921 C C   . LEU C 2 206 ? -56.111 25.344  -31.434  1.00 46.46  ? 218  LEU B C   1 
ATOM   1922 O O   . LEU C 2 206 ? -56.773 25.258  -30.393  1.00 49.46  ? 218  LEU B O   1 
ATOM   1923 C CB  . LEU C 2 206 ? -54.386 27.146  -31.598  1.00 34.22  ? 218  LEU B CB  1 
ATOM   1924 C CG  . LEU C 2 206 ? -53.040 27.717  -31.152  1.00 47.11  ? 218  LEU B CG  1 
ATOM   1925 C CD1 . LEU C 2 206 ? -52.087 27.855  -32.330  1.00 51.88  ? 218  LEU B CD1 1 
ATOM   1926 C CD2 . LEU C 2 206 ? -53.228 29.050  -30.445  1.00 39.78  ? 218  LEU B CD2 1 
ATOM   1927 N N   . GLN C 2 207 ? -56.657 25.177  -32.641  1.00 46.99  ? 219  GLN B N   1 
ATOM   1928 C CA  . GLN C 2 207 ? -58.070 24.845  -32.769  1.00 53.04  ? 219  GLN B CA  1 
ATOM   1929 C C   . GLN C 2 207 ? -58.374 23.461  -32.213  1.00 46.77  ? 219  GLN B C   1 
ATOM   1930 O O   . GLN C 2 207 ? -59.458 23.241  -31.661  1.00 47.78  ? 219  GLN B O   1 
ATOM   1931 C CB  . GLN C 2 207 ? -58.500 24.940  -34.234  1.00 54.83  ? 219  GLN B CB  1 
ATOM   1932 C CG  . GLN C 2 207 ? -59.950 24.556  -34.491  1.00 67.88  ? 219  GLN B CG  1 
ATOM   1933 C CD  . GLN C 2 207 ? -60.934 25.505  -33.829  1.00 77.61  ? 219  GLN B CD  1 
ATOM   1934 O OE1 . GLN C 2 207 ? -60.591 26.636  -33.479  1.00 69.79  ? 219  GLN B OE1 1 
ATOM   1935 N NE2 . GLN C 2 207 ? -62.171 25.049  -33.664  1.00 80.03  ? 219  GLN B NE2 1 
ATOM   1936 N N   . LEU C 2 208 ? -57.433 22.523  -32.334  1.00 40.48  ? 220  LEU B N   1 
ATOM   1937 C CA  . LEU C 2 208 ? -57.671 21.175  -31.829  1.00 37.37  ? 220  LEU B CA  1 
ATOM   1938 C C   . LEU C 2 208 ? -57.606 21.121  -30.309  1.00 46.81  ? 220  LEU B C   1 
ATOM   1939 O O   . LEU C 2 208 ? -58.259 20.270  -29.693  1.00 50.57  ? 220  LEU B O   1 
ATOM   1940 C CB  . LEU C 2 208 ? -56.670 20.200  -32.442  1.00 23.59  ? 220  LEU B CB  1 
ATOM   1941 C CG  . LEU C 2 208 ? -56.881 19.901  -33.927  1.00 27.75  ? 220  LEU B CG  1 
ATOM   1942 C CD1 . LEU C 2 208 ? -56.254 18.569  -34.293  1.00 33.50  ? 220  LEU B CD1 1 
ATOM   1943 C CD2 . LEU C 2 208 ? -58.364 19.919  -34.287  1.00 35.04  ? 220  LEU B CD2 1 
ATOM   1944 N N   . SER C 2 209 ? -56.831 22.008  -29.684  1.00 37.19  ? 221  SER B N   1 
ATOM   1945 C CA  . SER C 2 209 ? -56.805 22.050  -28.228  1.00 30.51  ? 221  SER B CA  1 
ATOM   1946 C C   . SER C 2 209 ? -58.113 22.576  -27.649  1.00 31.65  ? 221  SER B C   1 
ATOM   1947 O O   . SER C 2 209 ? -58.415 22.300  -26.484  1.00 45.24  ? 221  SER B O   1 
ATOM   1948 C CB  . SER C 2 209 ? -55.626 22.899  -27.744  1.00 33.05  ? 221  SER B CB  1 
ATOM   1949 O OG  . SER C 2 209 ? -55.905 24.283  -27.856  1.00 41.50  ? 221  SER B OG  1 
ATOM   1950 N N   . LYS C 2 210 ? -58.895 23.314  -28.436  1.00 38.34  ? 222  LYS B N   1 
ATOM   1951 C CA  . LYS C 2 210 ? -60.204 23.793  -28.010  1.00 41.42  ? 222  LYS B CA  1 
ATOM   1952 C C   . LYS C 2 210 ? -61.352 23.007  -28.627  1.00 48.91  ? 222  LYS B C   1 
ATOM   1953 O O   . LYS C 2 210 ? -62.414 22.891  -28.008  1.00 60.47  ? 222  LYS B O   1 
ATOM   1954 C CB  . LYS C 2 210 ? -60.361 25.278  -28.356  1.00 51.97  ? 222  LYS B CB  1 
ATOM   1955 C CG  . LYS C 2 210 ? -59.130 26.120  -28.031  1.00 47.53  ? 222  LYS B CG  1 
ATOM   1956 C CD  . LYS C 2 210 ? -58.980 27.318  -28.969  1.00 36.95  ? 222  LYS B CD  1 
ATOM   1957 C CE  . LYS C 2 210 ? -60.321 27.812  -29.498  1.00 58.62  ? 222  LYS B CE  1 
ATOM   1958 N NZ  . LYS C 2 210 ? -60.159 28.935  -30.467  1.00 76.81  ? 222  LYS B NZ  1 
ATOM   1959 N N   . GLU C 2 211 ? -61.162 22.477  -29.835  1.00 56.19  ? 223  GLU B N   1 
ATOM   1960 C CA  A GLU C 2 211 ? -62.138 21.616  -30.503  0.62 57.40  ? 223  GLU B CA  1 
ATOM   1961 C CA  B GLU C 2 211 ? -62.140 21.612  -30.494  0.38 57.33  ? 223  GLU B CA  1 
ATOM   1962 C C   . GLU C 2 211 ? -61.405 20.351  -30.923  1.00 50.61  ? 223  GLU B C   1 
ATOM   1963 O O   . GLU C 2 211 ? -60.841 20.285  -32.025  1.00 65.46  ? 223  GLU B O   1 
ATOM   1964 C CB  A GLU C 2 211 ? -62.773 22.315  -31.704  0.62 60.59  ? 223  GLU B CB  1 
ATOM   1965 C CB  B GLU C 2 211 ? -62.804 22.313  -31.678  0.38 60.52  ? 223  GLU B CB  1 
ATOM   1966 C CG  A GLU C 2 211 ? -64.233 22.700  -31.517  0.62 60.46  ? 223  GLU B CG  1 
ATOM   1967 C CG  B GLU C 2 211 ? -63.751 23.437  -31.282  0.38 62.03  ? 223  GLU B CG  1 
ATOM   1968 C CD  A GLU C 2 211 ? -64.776 23.505  -32.685  0.62 57.90  ? 223  GLU B CD  1 
ATOM   1969 C CD  B GLU C 2 211 ? -64.907 22.961  -30.422  0.38 57.81  ? 223  GLU B CD  1 
ATOM   1970 O OE1 A GLU C 2 211 ? -64.814 22.969  -33.813  0.62 59.63  ? 223  GLU B OE1 1 
ATOM   1971 O OE1 B GLU C 2 211 ? -65.458 21.876  -30.707  0.38 53.97  ? 223  GLU B OE1 1 
ATOM   1972 O OE2 A GLU C 2 211 ? -65.162 24.674  -32.475  0.62 62.92  ? 223  GLU B OE2 1 
ATOM   1973 O OE2 B GLU C 2 211 ? -65.266 23.673  -29.461  0.38 53.15  ? 223  GLU B OE2 1 
ATOM   1974 N N   . PRO C 2 212 ? -61.388 19.325  -30.075  1.00 41.49  ? 224  PRO B N   1 
ATOM   1975 C CA  . PRO C 2 212 ? -60.567 18.144  -30.361  1.00 50.06  ? 224  PRO B CA  1 
ATOM   1976 C C   . PRO C 2 212 ? -61.207 17.206  -31.374  1.00 51.41  ? 224  PRO B C   1 
ATOM   1977 O O   . PRO C 2 212 ? -62.419 16.979  -31.371  1.00 51.13  ? 224  PRO B O   1 
ATOM   1978 C CB  . PRO C 2 212 ? -60.437 17.472  -28.989  1.00 48.65  ? 224  PRO B CB  1 
ATOM   1979 C CG  . PRO C 2 212 ? -61.694 17.855  -28.270  1.00 54.67  ? 224  PRO B CG  1 
ATOM   1980 C CD  . PRO C 2 212 ? -62.157 19.184  -28.826  1.00 48.47  ? 224  PRO B CD  1 
ATOM   1981 N N   . SER C 2 213 ? -60.364 16.664  -32.251  1.00 43.44  ? 225  SER B N   1 
ATOM   1982 C CA  . SER C 2 213 ? -60.763 15.623  -33.191  1.00 39.47  ? 225  SER B CA  1 
ATOM   1983 C C   . SER C 2 213 ? -59.653 14.589  -33.248  1.00 46.21  ? 225  SER B C   1 
ATOM   1984 O O   . SER C 2 213 ? -58.497 14.932  -33.518  1.00 36.54  ? 225  SER B O   1 
ATOM   1985 C CB  . SER C 2 213 ? -61.037 16.191  -34.584  1.00 46.90  ? 225  SER B CB  1 
ATOM   1986 O OG  . SER C 2 213 ? -61.070 15.151  -35.548  1.00 39.61  ? 225  SER B OG  1 
ATOM   1987 N N   . ALA C 2 214 ? -60.008 13.328  -32.995  1.00 53.89  ? 226  ALA B N   1 
ATOM   1988 C CA  . ALA C 2 214 ? -59.008 12.268  -32.941  1.00 49.38  ? 226  ALA B CA  1 
ATOM   1989 C C   . ALA C 2 214 ? -58.339 12.073  -34.295  1.00 41.62  ? 226  ALA B C   1 
ATOM   1990 O O   . ALA C 2 214 ? -57.107 12.089  -34.401  1.00 40.80  ? 226  ALA B O   1 
ATOM   1991 C CB  . ALA C 2 214 ? -59.653 10.968  -32.465  1.00 52.19  ? 226  ALA B CB  1 
ATOM   1992 N N   . ARG C 2 215 ? -59.141 11.890  -35.347  1.00 34.72  ? 227  ARG B N   1 
ATOM   1993 C CA  . ARG C 2 215 ? -58.570 11.635  -36.665  1.00 32.22  ? 227  ARG B CA  1 
ATOM   1994 C C   . ARG C 2 215 ? -57.822 12.854  -37.192  1.00 39.09  ? 227  ARG B C   1 
ATOM   1995 O O   . ARG C 2 215 ? -56.774 12.714  -37.835  1.00 45.59  ? 227  ARG B O   1 
ATOM   1996 C CB  . ARG C 2 215 ? -59.663 11.202  -37.645  1.00 32.22  ? 227  ARG B CB  1 
ATOM   1997 C CG  . ARG C 2 215 ? -60.979 11.952  -37.524  1.00 25.36  ? 227  ARG B CG  1 
ATOM   1998 C CD  . ARG C 2 215 ? -61.971 11.444  -38.561  1.00 29.63  ? 227  ARG B CD  1 
ATOM   1999 N NE  . ARG C 2 215 ? -63.231 12.177  -38.539  1.00 31.40  ? 227  ARG B NE  1 
ATOM   2000 C CZ  . ARG C 2 215 ? -64.327 11.806  -39.190  1.00 35.23  ? 227  ARG B CZ  1 
ATOM   2001 N NH1 . ARG C 2 215 ? -64.356 10.706  -39.926  1.00 26.56  ? 227  ARG B NH1 1 
ATOM   2002 N NH2 . ARG C 2 215 ? -65.421 12.558  -39.101  1.00 35.57  ? 227  ARG B NH2 1 
ATOM   2003 N N   . LEU C 2 216 ? -58.338 14.056  -36.931  1.00 38.07  ? 228  LEU B N   1 
ATOM   2004 C CA  . LEU C 2 216 ? -57.634 15.261  -37.358  1.00 33.68  ? 228  LEU B CA  1 
ATOM   2005 C C   . LEU C 2 216 ? -56.261 15.346  -36.706  1.00 33.64  ? 228  LEU B C   1 
ATOM   2006 O O   . LEU C 2 216 ? -55.249 15.558  -37.385  1.00 31.71  ? 228  LEU B O   1 
ATOM   2007 C CB  . LEU C 2 216 ? -58.461 16.501  -37.027  1.00 30.06  ? 228  LEU B CB  1 
ATOM   2008 C CG  . LEU C 2 216 ? -58.936 17.355  -38.203  1.00 23.70  ? 228  LEU B CG  1 
ATOM   2009 C CD1 . LEU C 2 216 ? -59.563 18.632  -37.681  1.00 28.83  ? 228  LEU B CD1 1 
ATOM   2010 C CD2 . LEU C 2 216 ? -57.796 17.669  -39.163  1.00 30.62  ? 228  LEU B CD2 1 
ATOM   2011 N N   . LEU C 2 217 ? -56.207 15.165  -35.385  1.00 33.14  ? 229  LEU B N   1 
ATOM   2012 C CA  . LEU C 2 217 ? -54.931 15.215  -34.682  1.00 33.64  ? 229  LEU B CA  1 
ATOM   2013 C C   . LEU C 2 217 ? -53.952 14.190  -35.241  1.00 31.55  ? 229  LEU B C   1 
ATOM   2014 O O   . LEU C 2 217 ? -52.747 14.456  -35.328  1.00 33.55  ? 229  LEU B O   1 
ATOM   2015 C CB  . LEU C 2 217 ? -55.150 14.994  -33.187  1.00 26.17  ? 229  LEU B CB  1 
ATOM   2016 C CG  . LEU C 2 217 ? -53.922 15.143  -32.287  1.00 26.30  ? 229  LEU B CG  1 
ATOM   2017 C CD1 . LEU C 2 217 ? -53.093 16.359  -32.685  1.00 20.42  ? 229  LEU B CD1 1 
ATOM   2018 C CD2 . LEU C 2 217 ? -54.345 15.225  -30.830  1.00 25.90  ? 229  LEU B CD2 1 
ATOM   2019 N N   . LYS C 2 218 ? -54.455 13.019  -35.639  1.00 27.23  ? 230  LYS B N   1 
ATOM   2020 C CA  . LYS C 2 218 ? -53.584 11.979  -36.176  1.00 30.33  ? 230  LYS B CA  1 
ATOM   2021 C C   . LYS C 2 218 ? -52.897 12.443  -37.454  1.00 41.40  ? 230  LYS B C   1 
ATOM   2022 O O   . LYS C 2 218 ? -51.669 12.360  -37.584  1.00 35.51  ? 230  LYS B O   1 
ATOM   2023 C CB  . LYS C 2 218 ? -54.391 10.704  -36.432  1.00 31.82  ? 230  LYS B CB  1 
ATOM   2024 C CG  . LYS C 2 218 ? -53.572 9.536   -36.974  1.00 27.32  ? 230  LYS B CG  1 
ATOM   2025 C CD  . LYS C 2 218 ? -54.284 8.208   -36.751  1.00 30.10  ? 230  LYS B CD  1 
ATOM   2026 C CE  . LYS C 2 218 ? -54.191 7.312   -37.978  1.00 33.11  ? 230  LYS B CE  1 
ATOM   2027 N NZ  . LYS C 2 218 ? -53.770 5.924   -37.626  1.00 43.18  ? 230  LYS B NZ  1 
ATOM   2028 N N   . HIS C 2 219 ? -53.677 12.946  -38.410  1.00 41.96  ? 231  HIS B N   1 
ATOM   2029 C CA  . HIS C 2 219 ? -53.116 13.307  -39.703  1.00 28.74  ? 231  HIS B CA  1 
ATOM   2030 C C   . HIS C 2 219 ? -52.339 14.615  -39.645  1.00 29.77  ? 231  HIS B C   1 
ATOM   2031 O O   . HIS C 2 219 ? -51.422 14.820  -40.446  1.00 33.64  ? 231  HIS B O   1 
ATOM   2032 C CB  . HIS C 2 219 ? -54.233 13.381  -40.742  1.00 28.84  ? 231  HIS B CB  1 
ATOM   2033 C CG  . HIS C 2 219 ? -54.948 12.081  -40.940  1.00 37.59  ? 231  HIS B CG  1 
ATOM   2034 N ND1 . HIS C 2 219 ? -56.296 11.928  -40.697  1.00 51.65  ? 231  HIS B ND1 1 
ATOM   2035 C CD2 . HIS C 2 219 ? -54.502 10.871  -41.356  1.00 40.21  ? 231  HIS B CD2 1 
ATOM   2036 C CE1 . HIS C 2 219 ? -56.649 10.681  -40.953  1.00 45.91  ? 231  HIS B CE1 1 
ATOM   2037 N NE2 . HIS C 2 219 ? -55.580 10.019  -41.357  1.00 46.02  ? 231  HIS B NE2 1 
ATOM   2038 N N   . VAL C 2 220 ? -52.677 15.503  -38.709  1.00 33.06  ? 232  VAL B N   1 
ATOM   2039 C CA  . VAL C 2 220 ? -51.874 16.707  -38.532  1.00 30.02  ? 232  VAL B CA  1 
ATOM   2040 C C   . VAL C 2 220 ? -50.483 16.342  -38.035  1.00 27.10  ? 232  VAL B C   1 
ATOM   2041 O O   . VAL C 2 220 ? -49.475 16.866  -38.525  1.00 25.09  ? 232  VAL B O   1 
ATOM   2042 C CB  . VAL C 2 220 ? -52.578 17.690  -37.581  1.00 25.04  ? 232  VAL B CB  1 
ATOM   2043 C CG1 . VAL C 2 220 ? -51.621 18.796  -37.166  1.00 21.18  ? 232  VAL B CG1 1 
ATOM   2044 C CG2 . VAL C 2 220 ? -53.809 18.275  -38.252  1.00 25.71  ? 232  VAL B CG2 1 
ATOM   2045 N N   . VAL C 2 221 ? -50.407 15.429  -37.065  1.00 27.52  ? 233  VAL B N   1 
ATOM   2046 C CA  . VAL C 2 221 ? -49.113 14.979  -36.560  1.00 28.00  ? 233  VAL B CA  1 
ATOM   2047 C C   . VAL C 2 221 ? -48.302 14.335  -37.675  1.00 31.29  ? 233  VAL B C   1 
ATOM   2048 O O   . VAL C 2 221 ? -47.103 14.602  -37.827  1.00 30.92  ? 233  VAL B O   1 
ATOM   2049 C CB  . VAL C 2 221 ? -49.315 14.017  -35.375  1.00 28.10  ? 233  VAL B CB  1 
ATOM   2050 C CG1 . VAL C 2 221 ? -48.079 13.156  -35.165  1.00 24.90  ? 233  VAL B CG1 1 
ATOM   2051 C CG2 . VAL C 2 221 ? -49.655 14.797  -34.112  1.00 31.03  ? 233  VAL B CG2 1 
ATOM   2052 N N   . ARG C 2 222 ? -48.945 13.487  -38.482  1.00 30.55  ? 234  ARG B N   1 
ATOM   2053 C CA  . ARG C 2 222 ? -48.233 12.816  -39.564  1.00 30.61  ? 234  ARG B CA  1 
ATOM   2054 C C   . ARG C 2 222 ? -47.660 13.822  -40.553  1.00 33.83  ? 234  ARG B C   1 
ATOM   2055 O O   . ARG C 2 222 ? -46.555 13.628  -41.075  1.00 48.70  ? 234  ARG B O   1 
ATOM   2056 C CB  . ARG C 2 222 ? -49.163 11.834  -40.273  1.00 32.49  ? 234  ARG B CB  1 
ATOM   2057 C CG  . ARG C 2 222 ? -48.468 10.973  -41.310  1.00 29.19  ? 234  ARG B CG  1 
ATOM   2058 C CD  . ARG C 2 222 ? -47.562 9.945   -40.652  1.00 23.11  ? 234  ARG B CD  1 
ATOM   2059 N NE  . ARG C 2 222 ? -46.699 9.291   -41.628  1.00 24.36  ? 234  ARG B NE  1 
ATOM   2060 C CZ  . ARG C 2 222 ? -45.568 9.807   -42.090  1.00 36.21  ? 234  ARG B CZ  1 
ATOM   2061 N NH1 . ARG C 2 222 ? -45.123 10.983  -41.676  1.00 35.68  ? 234  ARG B NH1 1 
ATOM   2062 N NH2 . ARG C 2 222 ? -44.866 9.125   -42.991  1.00 52.66  ? 234  ARG B NH2 1 
ATOM   2063 N N   . CYS C 2 223 ? -48.394 14.907  -40.816  1.00 34.04  ? 235  CYS B N   1 
ATOM   2064 C CA  . CYS C 2 223 ? -47.892 15.943  -41.714  1.00 29.31  ? 235  CYS B CA  1 
ATOM   2065 C C   . CYS C 2 223 ? -46.649 16.608  -41.136  1.00 34.47  ? 235  CYS B C   1 
ATOM   2066 O O   . CYS C 2 223 ? -45.650 16.801  -41.838  1.00 30.99  ? 235  CYS B O   1 
ATOM   2067 C CB  . CYS C 2 223 ? -48.987 16.978  -41.983  1.00 24.12  ? 235  CYS B CB  1 
ATOM   2068 S SG  . CYS C 2 223 ? -50.261 16.449  -43.166  1.00 37.29  ? 235  CYS B SG  1 
ATOM   2069 N N   . TYR C 2 224 ? -46.692 16.957  -39.846  1.00 37.61  ? 236  TYR B N   1 
ATOM   2070 C CA  . TYR C 2 224 ? -45.522 17.534  -39.190  1.00 26.36  ? 236  TYR B CA  1 
ATOM   2071 C C   . TYR C 2 224 ? -44.337 16.577  -39.236  1.00 37.99  ? 236  TYR B C   1 
ATOM   2072 O O   . TYR C 2 224 ? -43.193 17.004  -39.434  1.00 39.29  ? 236  TYR B O   1 
ATOM   2073 C CB  . TYR C 2 224 ? -45.858 17.895  -37.744  1.00 25.27  ? 236  TYR B CB  1 
ATOM   2074 C CG  . TYR C 2 224 ? -46.370 19.304  -37.555  1.00 24.89  ? 236  TYR B CG  1 
ATOM   2075 C CD1 . TYR C 2 224 ? -45.572 20.400  -37.857  1.00 23.32  ? 236  TYR B CD1 1 
ATOM   2076 C CD2 . TYR C 2 224 ? -47.648 19.540  -37.058  1.00 28.53  ? 236  TYR B CD2 1 
ATOM   2077 C CE1 . TYR C 2 224 ? -46.036 21.695  -37.678  1.00 43.37  ? 236  TYR B CE1 1 
ATOM   2078 C CE2 . TYR C 2 224 ? -48.122 20.830  -36.874  1.00 31.10  ? 236  TYR B CE2 1 
ATOM   2079 C CZ  . TYR C 2 224 ? -47.311 21.904  -37.185  1.00 39.74  ? 236  TYR B CZ  1 
ATOM   2080 O OH  . TYR C 2 224 ? -47.778 23.188  -37.008  1.00 27.63  ? 236  TYR B OH  1 
ATOM   2081 N N   . LEU C 2 225 ? -44.592 15.277  -39.052  1.00 40.28  ? 237  LEU B N   1 
ATOM   2082 C CA  . LEU C 2 225 ? -43.518 14.289  -39.120  1.00 37.51  ? 237  LEU B CA  1 
ATOM   2083 C C   . LEU C 2 225 ? -42.878 14.273  -40.501  1.00 43.59  ? 237  LEU B C   1 
ATOM   2084 O O   . LEU C 2 225 ? -41.648 14.262  -40.629  1.00 55.17  ? 237  LEU B O   1 
ATOM   2085 C CB  . LEU C 2 225 ? -44.056 12.902  -38.765  1.00 28.11  ? 237  LEU B CB  1 
ATOM   2086 C CG  . LEU C 2 225 ? -43.126 11.940  -38.013  1.00 43.39  ? 237  LEU B CG  1 
ATOM   2087 C CD1 . LEU C 2 225 ? -43.837 10.625  -37.744  1.00 34.88  ? 237  LEU B CD1 1 
ATOM   2088 C CD2 . LEU C 2 225 ? -41.817 11.683  -38.757  1.00 44.09  ? 237  LEU B CD2 1 
ATOM   2089 N N   . ARG C 2 226 ? -43.702 14.263  -41.550  1.00 35.04  ? 238  ARG B N   1 
ATOM   2090 C CA  . ARG C 2 226 ? -43.159 14.218  -42.902  1.00 29.42  ? 238  ARG B CA  1 
ATOM   2091 C C   . ARG C 2 226 ? -42.352 15.471  -43.223  1.00 37.25  ? 238  ARG B C   1 
ATOM   2092 O O   . ARG C 2 226 ? -41.340 15.389  -43.928  1.00 37.50  ? 238  ARG B O   1 
ATOM   2093 C CB  . ARG C 2 226 ? -44.290 14.019  -43.908  1.00 23.94  ? 238  ARG B CB  1 
ATOM   2094 C CG  . ARG C 2 226 ? -43.824 13.717  -45.320  1.00 40.65  ? 238  ARG B CG  1 
ATOM   2095 C CD  . ARG C 2 226 ? -42.717 12.677  -45.358  1.00 43.76  ? 238  ARG B CD  1 
ATOM   2096 N NE  . ARG C 2 226 ? -41.918 12.810  -46.571  1.00 34.73  ? 238  ARG B NE  1 
ATOM   2097 C CZ  . ARG C 2 226 ? -41.437 11.796  -47.275  1.00 39.28  ? 238  ARG B CZ  1 
ATOM   2098 N NH1 . ARG C 2 226 ? -41.656 10.541  -46.919  1.00 71.65  ? 238  ARG B NH1 1 
ATOM   2099 N NH2 . ARG C 2 226 ? -40.718 12.048  -48.365  1.00 37.02  ? 238  ARG B NH2 1 
ATOM   2100 N N   . LEU C 2 227 ? -42.765 16.631  -42.703  1.00 34.16  ? 239  LEU B N   1 
ATOM   2101 C CA  . LEU C 2 227 ? -41.965 17.841  -42.886  1.00 26.27  ? 239  LEU B CA  1 
ATOM   2102 C C   . LEU C 2 227 ? -40.620 17.724  -42.183  1.00 42.92  ? 239  LEU B C   1 
ATOM   2103 O O   . LEU C 2 227 ? -39.600 18.198  -42.699  1.00 36.83  ? 239  LEU B O   1 
ATOM   2104 C CB  . LEU C 2 227 ? -42.722 19.066  -42.377  1.00 21.75  ? 239  LEU B CB  1 
ATOM   2105 C CG  . LEU C 2 227 ? -44.128 19.304  -42.921  1.00 25.54  ? 239  LEU B CG  1 
ATOM   2106 C CD1 . LEU C 2 227 ? -44.583 20.724  -42.625  1.00 35.48  ? 239  LEU B CD1 1 
ATOM   2107 C CD2 . LEU C 2 227 ? -44.166 19.029  -44.412  1.00 29.46  ? 239  LEU B CD2 1 
ATOM   2108 N N   . SER C 2 228 ? -40.597 17.090  -41.006  1.00 41.68  ? 240  SER B N   1 
ATOM   2109 C CA  . SER C 2 228 ? -39.354 16.920  -40.263  1.00 36.81  ? 240  SER B CA  1 
ATOM   2110 C C   . SER C 2 228 ? -38.329 16.093  -41.027  1.00 48.03  ? 240  SER B C   1 
ATOM   2111 O O   . SER C 2 228 ? -37.145 16.116  -40.673  1.00 62.14  ? 240  SER B O   1 
ATOM   2112 C CB  . SER C 2 228 ? -39.640 16.272  -38.907  1.00 48.15  ? 240  SER B CB  1 
ATOM   2113 O OG  . SER C 2 228 ? -39.945 14.895  -39.053  1.00 63.30  ? 240  SER B OG  1 
ATOM   2114 N N   . ASP C 2 229 ? -38.754 15.364  -42.062  1.00 39.19  ? 241  ASP B N   1 
ATOM   2115 C CA  . ASP C 2 229 ? -37.834 14.579  -42.875  1.00 48.87  ? 241  ASP B CA  1 
ATOM   2116 C C   . ASP C 2 229 ? -36.997 15.436  -43.816  1.00 52.24  ? 241  ASP B C   1 
ATOM   2117 O O   . ASP C 2 229 ? -36.014 14.934  -44.373  1.00 55.04  ? 241  ASP B O   1 
ATOM   2118 C CB  . ASP C 2 229 ? -38.610 13.535  -43.681  1.00 50.42  ? 241  ASP B CB  1 
ATOM   2119 C CG  . ASP C 2 229 ? -38.619 12.171  -43.014  1.00 72.47  ? 241  ASP B CG  1 
ATOM   2120 O OD1 . ASP C 2 229 ? -39.522 11.363  -43.319  1.00 79.37  ? 241  ASP B OD1 1 
ATOM   2121 O OD2 . ASP C 2 229 ? -37.725 11.910  -42.180  1.00 93.04  ? 241  ASP B OD2 1 
ATOM   2122 N N   . ASN C 2 230 ? -37.359 16.702  -44.009  1.00 41.27  ? 242  ASN B N   1 
ATOM   2123 C CA  . ASN C 2 230 ? -36.614 17.627  -44.855  1.00 47.52  ? 242  ASN B CA  1 
ATOM   2124 C C   . ASN C 2 230 ? -35.638 18.442  -44.007  1.00 49.85  ? 242  ASN B C   1 
ATOM   2125 O O   . ASN C 2 230 ? -36.005 18.922  -42.930  1.00 55.19  ? 242  ASN B O   1 
ATOM   2126 C CB  . ASN C 2 230 ? -37.570 18.560  -45.595  1.00 47.00  ? 242  ASN B CB  1 
ATOM   2127 C CG  . ASN C 2 230 ? -36.853 19.568  -46.477  1.00 50.44  ? 242  ASN B CG  1 
ATOM   2128 O OD1 . ASN C 2 230 ? -36.304 20.558  -45.991  1.00 58.63  ? 242  ASN B OD1 1 
ATOM   2129 N ND2 . ASN C 2 230 ? -36.876 19.332  -47.785  1.00 33.24  ? 242  ASN B ND2 1 
ATOM   2130 N N   . PRO C 2 231 ? -34.388 18.600  -44.467  1.00 49.51  ? 243  PRO B N   1 
ATOM   2131 C CA  . PRO C 2 231 ? -33.371 19.283  -43.651  1.00 46.82  ? 243  PRO B CA  1 
ATOM   2132 C C   . PRO C 2 231 ? -33.732 20.720  -43.305  1.00 54.00  ? 243  PRO B C   1 
ATOM   2133 O O   . PRO C 2 231 ? -33.832 21.071  -42.124  1.00 70.17  ? 243  PRO B O   1 
ATOM   2134 C CB  . PRO C 2 231 ? -32.117 19.223  -44.534  1.00 54.55  ? 243  PRO B CB  1 
ATOM   2135 C CG  . PRO C 2 231 ? -32.352 18.066  -45.452  1.00 48.73  ? 243  PRO B CG  1 
ATOM   2136 C CD  . PRO C 2 231 ? -33.826 18.067  -45.720  1.00 51.47  ? 243  PRO B CD  1 
ATOM   2137 N N   . ARG C 2 232 ? -33.919 21.564  -44.324  1.00 51.78  ? 244  ARG B N   1 
ATOM   2138 C CA  . ARG C 2 232 ? -34.283 22.954  -44.069  1.00 64.29  ? 244  ARG B CA  1 
ATOM   2139 C C   . ARG C 2 232 ? -35.638 23.061  -43.383  1.00 70.07  ? 244  ARG B C   1 
ATOM   2140 O O   . ARG C 2 232 ? -35.868 23.991  -42.601  1.00 86.68  ? 244  ARG B O   1 
ATOM   2141 C CB  . ARG C 2 232 ? -34.286 23.751  -45.375  1.00 81.41  ? 244  ARG B CB  1 
ATOM   2142 C CG  . ARG C 2 232 ? -33.002 24.528  -45.633  1.00 97.73  ? 244  ARG B CG  1 
ATOM   2143 C CD  . ARG C 2 232 ? -32.557 25.303  -44.397  1.00 106.91 ? 244  ARG B CD  1 
ATOM   2144 N NE  . ARG C 2 232 ? -33.302 26.544  -44.217  1.00 111.74 ? 244  ARG B NE  1 
ATOM   2145 C CZ  . ARG C 2 232 ? -34.177 26.759  -43.244  1.00 104.09 ? 244  ARG B CZ  1 
ATOM   2146 N NH1 . ARG C 2 232 ? -34.458 25.828  -42.347  1.00 95.58  ? 244  ARG B NH1 1 
ATOM   2147 N NH2 . ARG C 2 232 ? -34.787 27.939  -43.169  1.00 105.68 ? 244  ARG B NH2 1 
ATOM   2148 N N   . ALA C 2 233 ? -36.546 22.125  -43.661  1.00 63.23  ? 245  ALA B N   1 
ATOM   2149 C CA  . ALA C 2 233 ? -37.835 22.131  -42.980  1.00 40.84  ? 245  ALA B CA  1 
ATOM   2150 C C   . ALA C 2 233 ? -37.682 21.779  -41.509  1.00 50.16  ? 245  ALA B C   1 
ATOM   2151 O O   . ALA C 2 233 ? -38.313 22.402  -40.646  1.00 55.27  ? 245  ALA B O   1 
ATOM   2152 C CB  . ALA C 2 233 ? -38.793 21.158  -43.661  1.00 53.40  ? 245  ALA B CB  1 
ATOM   2153 N N   . ARG C 2 234 ? -36.849 20.781  -41.205  1.00 56.01  ? 246  ARG B N   1 
ATOM   2154 C CA  . ARG C 2 234 ? -36.678 20.356  -39.821  1.00 53.31  ? 246  ARG B CA  1 
ATOM   2155 C C   . ARG C 2 234 ? -36.138 21.492  -38.963  1.00 52.55  ? 246  ARG B C   1 
ATOM   2156 O O   . ARG C 2 234 ? -36.566 21.668  -37.817  1.00 64.09  ? 246  ARG B O   1 
ATOM   2157 C CB  . ARG C 2 234 ? -35.762 19.133  -39.760  1.00 49.94  ? 246  ARG B CB  1 
ATOM   2158 C CG  . ARG C 2 234 ? -34.729 19.164  -38.652  1.00 59.31  ? 246  ARG B CG  1 
ATOM   2159 C CD  . ARG C 2 234 ? -33.815 17.958  -38.739  1.00 70.84  ? 246  ARG B CD  1 
ATOM   2160 N NE  . ARG C 2 234 ? -34.568 16.710  -38.753  1.00 81.25  ? 246  ARG B NE  1 
ATOM   2161 C CZ  . ARG C 2 234 ? -34.174 15.605  -39.372  1.00 91.64  ? 246  ARG B CZ  1 
ATOM   2162 N NH1 . ARG C 2 234 ? -33.041 15.562  -40.054  1.00 101.52 ? 246  ARG B NH1 1 
ATOM   2163 N NH2 . ARG C 2 234 ? -34.936 14.516  -39.304  1.00 68.57  ? 246  ARG B NH2 1 
ATOM   2164 N N   . GLU C 2 235 ? -35.209 22.282  -39.506  1.00 49.32  ? 247  GLU B N   1 
ATOM   2165 C CA  . GLU C 2 235 ? -34.709 23.447  -38.782  1.00 68.24  ? 247  GLU B CA  1 
ATOM   2166 C C   . GLU C 2 235 ? -35.853 24.392  -38.437  1.00 65.42  ? 247  GLU B C   1 
ATOM   2167 O O   . GLU C 2 235 ? -36.131 24.648  -37.260  1.00 71.86  ? 247  GLU B O   1 
ATOM   2168 C CB  . GLU C 2 235 ? -33.634 24.153  -39.616  1.00 71.29  ? 247  GLU B CB  1 
ATOM   2169 C CG  . GLU C 2 235 ? -33.396 25.647  -39.327  1.00 88.85  ? 247  GLU B CG  1 
ATOM   2170 C CD  . GLU C 2 235 ? -33.097 25.966  -37.867  1.00 89.94  ? 247  GLU B CD  1 
ATOM   2171 O OE1 . GLU C 2 235 ? -34.038 26.270  -37.104  1.00 86.36  ? 247  GLU B OE1 1 
ATOM   2172 O OE2 . GLU C 2 235 ? -31.913 25.913  -37.481  1.00 91.48  ? 247  GLU B OE2 1 
ATOM   2173 N N   . ALA C 2 236 ? -36.561 24.884  -39.459  1.00 57.92  ? 248  ALA B N   1 
ATOM   2174 C CA  . ALA C 2 236 ? -37.631 25.850  -39.244  1.00 56.74  ? 248  ALA B CA  1 
ATOM   2175 C C   . ALA C 2 236 ? -38.690 25.353  -38.268  1.00 51.47  ? 248  ALA B C   1 
ATOM   2176 O O   . ALA C 2 236 ? -39.391 26.170  -37.664  1.00 47.38  ? 248  ALA B O   1 
ATOM   2177 C CB  . ALA C 2 236 ? -38.287 26.208  -40.580  1.00 63.65  ? 248  ALA B CB  1 
ATOM   2178 N N   . LEU C 2 237 ? -38.810 24.036  -38.085  1.00 57.18  ? 249  LEU B N   1 
ATOM   2179 C CA  . LEU C 2 237 ? -39.843 23.496  -37.208  1.00 57.83  ? 249  LEU B CA  1 
ATOM   2180 C C   . LEU C 2 237 ? -39.437 23.507  -35.739  1.00 59.51  ? 249  LEU B C   1 
ATOM   2181 O O   . LEU C 2 237 ? -40.311 23.534  -34.866  1.00 60.25  ? 249  LEU B O   1 
ATOM   2182 C CB  . LEU C 2 237 ? -40.204 22.073  -37.639  1.00 59.21  ? 249  LEU B CB  1 
ATOM   2183 C CG  . LEU C 2 237 ? -41.246 21.953  -38.755  1.00 56.75  ? 249  LEU B CG  1 
ATOM   2184 C CD1 . LEU C 2 237 ? -41.967 20.617  -38.675  1.00 56.70  ? 249  LEU B CD1 1 
ATOM   2185 C CD2 . LEU C 2 237 ? -42.240 23.104  -38.691  1.00 52.84  ? 249  LEU B CD2 1 
ATOM   2186 N N   . ARG C 2 238 ? -38.133 23.480  -35.439  1.00 55.71  ? 250  ARG B N   1 
ATOM   2187 C CA  . ARG C 2 238 ? -37.707 23.491  -34.041  1.00 56.81  ? 250  ARG B CA  1 
ATOM   2188 C C   . ARG C 2 238 ? -38.141 24.767  -33.331  1.00 51.07  ? 250  ARG B C   1 
ATOM   2189 O O   . ARG C 2 238 ? -38.463 24.737  -32.137  1.00 66.82  ? 250  ARG B O   1 
ATOM   2190 C CB  . ARG C 2 238 ? -36.190 23.318  -33.937  1.00 51.54  ? 250  ARG B CB  1 
ATOM   2191 C CG  . ARG C 2 238 ? -35.596 22.293  -34.887  1.00 47.78  ? 250  ARG B CG  1 
ATOM   2192 C CD  . ARG C 2 238 ? -34.097 22.149  -34.667  1.00 50.02  ? 250  ARG B CD  1 
ATOM   2193 N NE  . ARG C 2 238 ? -33.516 21.088  -35.481  1.00 64.66  ? 250  ARG B NE  1 
ATOM   2194 C CZ  . ARG C 2 238 ? -32.530 21.267  -36.351  1.00 68.10  ? 250  ARG B CZ  1 
ATOM   2195 N NH1 . ARG C 2 238 ? -31.995 22.460  -36.554  1.00 65.89  ? 250  ARG B NH1 1 
ATOM   2196 N NH2 . ARG C 2 238 ? -32.070 20.223  -37.035  1.00 57.44  ? 250  ARG B NH2 1 
ATOM   2197 N N   . GLN C 2 239 ? -38.159 25.893  -34.042  1.00 40.26  ? 251  GLN B N   1 
ATOM   2198 C CA  . GLN C 2 239 ? -38.658 27.142  -33.484  1.00 46.77  ? 251  GLN B CA  1 
ATOM   2199 C C   . GLN C 2 239 ? -40.135 27.370  -33.771  1.00 53.87  ? 251  GLN B C   1 
ATOM   2200 O O   . GLN C 2 239 ? -40.757 28.210  -33.111  1.00 58.09  ? 251  GLN B O   1 
ATOM   2201 C CB  . GLN C 2 239 ? -37.859 28.335  -34.021  1.00 51.40  ? 251  GLN B CB  1 
ATOM   2202 C CG  . GLN C 2 239 ? -36.360 28.306  -33.739  1.00 67.79  ? 251  GLN B CG  1 
ATOM   2203 C CD  . GLN C 2 239 ? -35.591 27.375  -34.662  1.00 79.95  ? 251  GLN B CD  1 
ATOM   2204 O OE1 . GLN C 2 239 ? -36.039 26.273  -34.972  1.00 74.28  ? 251  GLN B OE1 1 
ATOM   2205 N NE2 . GLN C 2 239 ? -34.425 27.825  -35.112  1.00 92.51  ? 251  GLN B NE2 1 
ATOM   2206 N N   . CYS C 2 240 ? -40.710 26.642  -34.731  1.00 63.58  ? 252  CYS B N   1 
ATOM   2207 C CA  . CYS C 2 240 ? -42.090 26.856  -35.150  1.00 63.89  ? 252  CYS B CA  1 
ATOM   2208 C C   . CYS C 2 240 ? -43.076 25.862  -34.553  1.00 59.72  ? 252  CYS B C   1 
ATOM   2209 O O   . CYS C 2 240 ? -44.269 26.178  -34.477  1.00 59.70  ? 252  CYS B O   1 
ATOM   2210 C CB  . CYS C 2 240 ? -42.195 26.794  -36.679  1.00 49.71  ? 252  CYS B CB  1 
ATOM   2211 S SG  . CYS C 2 240 ? -43.754 27.398  -37.374  1.00 108.10 ? 252  CYS B SG  1 
ATOM   2212 N N   . LEU C 2 241 ? -42.618 24.682  -34.137  1.00 47.12  ? 253  LEU B N   1 
ATOM   2213 C CA  . LEU C 2 241 ? -43.526 23.639  -33.681  1.00 44.76  ? 253  LEU B CA  1 
ATOM   2214 C C   . LEU C 2 241 ? -44.410 24.164  -32.554  1.00 60.72  ? 253  LEU B C   1 
ATOM   2215 O O   . LEU C 2 241 ? -43.891 24.731  -31.582  1.00 73.22  ? 253  LEU B O   1 
ATOM   2216 C CB  . LEU C 2 241 ? -42.745 22.416  -33.203  1.00 42.64  ? 253  LEU B CB  1 
ATOM   2217 C CG  . LEU C 2 241 ? -43.538 21.122  -33.001  1.00 47.87  ? 253  LEU B CG  1 
ATOM   2218 C CD1 . LEU C 2 241 ? -44.487 20.870  -34.163  1.00 38.82  ? 253  LEU B CD1 1 
ATOM   2219 C CD2 . LEU C 2 241 ? -42.596 19.947  -32.812  1.00 59.29  ? 253  LEU B CD2 1 
ATOM   2220 N N   . PRO C 2 242 ? -45.734 24.036  -32.661  1.00 55.81  ? 254  PRO B N   1 
ATOM   2221 C CA  . PRO C 2 242 ? -46.610 24.456  -31.562  1.00 57.97  ? 254  PRO B CA  1 
ATOM   2222 C C   . PRO C 2 242 ? -46.200 23.820  -30.241  1.00 57.57  ? 254  PRO B C   1 
ATOM   2223 O O   . PRO C 2 242 ? -45.884 22.630  -30.170  1.00 61.49  ? 254  PRO B O   1 
ATOM   2224 C CB  . PRO C 2 242 ? -47.994 23.973  -32.008  1.00 58.05  ? 254  PRO B CB  1 
ATOM   2225 C CG  . PRO C 2 242 ? -47.920 23.854  -33.489  1.00 45.18  ? 254  PRO B CG  1 
ATOM   2226 C CD  . PRO C 2 242 ? -46.480 23.757  -33.902  1.00 51.85  ? 254  PRO B CD  1 
ATOM   2227 N N   . ASP C 2 243 ? -46.200 24.636  -29.186  1.00 54.46  ? 255  ASP B N   1 
ATOM   2228 C CA  . ASP C 2 243 ? -45.847 24.126  -27.867  1.00 47.95  ? 255  ASP B CA  1 
ATOM   2229 C C   . ASP C 2 243 ? -46.870 23.113  -27.371  1.00 41.52  ? 255  ASP B C   1 
ATOM   2230 O O   . ASP C 2 243 ? -46.528 22.233  -26.572  1.00 47.34  ? 255  ASP B O   1 
ATOM   2231 C CB  . ASP C 2 243 ? -45.710 25.285  -26.880  1.00 61.97  ? 255  ASP B CB  1 
ATOM   2232 C CG  . ASP C 2 243 ? -45.066 26.513  -27.507  1.00 79.86  ? 255  ASP B CG  1 
ATOM   2233 O OD1 . ASP C 2 243 ? -45.688 27.122  -28.403  1.00 82.91  ? 255  ASP B OD1 1 
ATOM   2234 O OD2 . ASP C 2 243 ? -43.940 26.873  -27.101  1.00 85.84  ? 255  ASP B OD2 1 
ATOM   2235 N N   . GLN C 2 244 ? -48.119 23.211  -27.840  1.00 47.06  ? 256  GLN B N   1 
ATOM   2236 C CA  . GLN C 2 244 ? -49.148 22.256  -27.437  1.00 46.01  ? 256  GLN B CA  1 
ATOM   2237 C C   . GLN C 2 244 ? -48.826 20.846  -27.912  1.00 43.76  ? 256  GLN B C   1 
ATOM   2238 O O   . GLN C 2 244 ? -49.290 19.869  -27.312  1.00 45.40  ? 256  GLN B O   1 
ATOM   2239 C CB  . GLN C 2 244 ? -50.512 22.695  -27.968  1.00 28.68  ? 256  GLN B CB  1 
ATOM   2240 C CG  . GLN C 2 244 ? -50.848 24.130  -27.637  1.00 37.04  ? 256  GLN B CG  1 
ATOM   2241 C CD  . GLN C 2 244 ? -50.487 25.074  -28.761  1.00 58.93  ? 256  GLN B CD  1 
ATOM   2242 O OE1 . GLN C 2 244 ? -49.341 25.515  -28.877  1.00 63.53  ? 256  GLN B OE1 1 
ATOM   2243 N NE2 . GLN C 2 244 ? -51.464 25.393  -29.597  1.00 63.94  ? 256  GLN B NE2 1 
ATOM   2244 N N   . LEU C 2 245 ? -48.049 20.719  -28.987  1.00 40.60  ? 257  LEU B N   1 
ATOM   2245 C CA  . LEU C 2 245 ? -47.545 19.407  -29.368  1.00 46.21  ? 257  LEU B CA  1 
ATOM   2246 C C   . LEU C 2 245 ? -46.431 18.952  -28.435  1.00 59.50  ? 257  LEU B C   1 
ATOM   2247 O O   . LEU C 2 245 ? -46.256 17.746  -28.220  1.00 61.65  ? 257  LEU B O   1 
ATOM   2248 C CB  . LEU C 2 245 ? -47.051 19.432  -30.812  1.00 53.95  ? 257  LEU B CB  1 
ATOM   2249 C CG  . LEU C 2 245 ? -47.932 18.720  -31.839  1.00 53.70  ? 257  LEU B CG  1 
ATOM   2250 C CD1 . LEU C 2 245 ? -49.384 19.158  -31.701  1.00 36.52  ? 257  LEU B CD1 1 
ATOM   2251 C CD2 . LEU C 2 245 ? -47.416 18.984  -33.240  1.00 37.60  ? 257  LEU B CD2 1 
ATOM   2252 N N   . LYS C 2 246 ? -45.679 19.896  -27.862  1.00 55.30  ? 258  LYS B N   1 
ATOM   2253 C CA  . LYS C 2 246 ? -44.563 19.540  -26.994  1.00 47.04  ? 258  LYS B CA  1 
ATOM   2254 C C   . LYS C 2 246 ? -45.005 19.235  -25.567  1.00 51.98  ? 258  LYS B C   1 
ATOM   2255 O O   . LYS C 2 246 ? -44.352 18.440  -24.882  1.00 53.96  ? 258  LYS B O   1 
ATOM   2256 C CB  . LYS C 2 246 ? -43.524 20.665  -26.980  1.00 44.28  ? 258  LYS B CB  1 
ATOM   2257 C CG  . LYS C 2 246 ? -42.956 21.023  -28.346  1.00 51.47  ? 258  LYS B CG  1 
ATOM   2258 C CD  . LYS C 2 246 ? -41.464 20.717  -28.426  1.00 35.71  ? 258  LYS B CD  1 
ATOM   2259 C CE  . LYS C 2 246 ? -40.762 21.629  -29.428  1.00 49.36  ? 258  LYS B CE  1 
ATOM   2260 N NZ  . LYS C 2 246 ? -41.030 23.074  -29.171  1.00 58.39  ? 258  LYS B NZ  1 
ATOM   2261 N N   . ASP C 2 247 ? -46.096 19.839  -25.104  1.00 57.04  ? 259  ASP B N   1 
ATOM   2262 C CA  . ASP C 2 247 ? -46.485 19.769  -23.704  1.00 44.25  ? 259  ASP B CA  1 
ATOM   2263 C C   . ASP C 2 247 ? -47.519 18.659  -23.479  1.00 42.79  ? 259  ASP B C   1 
ATOM   2264 O O   . ASP C 2 247 ? -47.586 17.684  -24.236  1.00 53.04  ? 259  ASP B O   1 
ATOM   2265 C CB  . ASP C 2 247 ? -46.982 21.152  -23.243  1.00 46.49  ? 259  ASP B CB  1 
ATOM   2266 C CG  . ASP C 2 247 ? -48.237 21.617  -23.976  1.00 55.79  ? 259  ASP B CG  1 
ATOM   2267 O OD1 . ASP C 2 247 ? -48.910 20.797  -24.635  1.00 61.34  ? 259  ASP B OD1 1 
ATOM   2268 O OD2 . ASP C 2 247 ? -48.555 22.822  -23.885  1.00 53.19  ? 259  ASP B OD2 1 
ATOM   2269 N N   . THR C 2 248 ? -48.333 18.807  -22.436  1.00 38.34  ? 260  THR B N   1 
ATOM   2270 C CA  . THR C 2 248 ? -49.306 17.803  -22.035  1.00 47.46  ? 260  THR B CA  1 
ATOM   2271 C C   . THR C 2 248 ? -50.708 18.105  -22.545  1.00 51.54  ? 260  THR B C   1 
ATOM   2272 O O   . THR C 2 248 ? -51.674 17.511  -22.054  1.00 58.44  ? 260  THR B O   1 
ATOM   2273 C CB  . THR C 2 248 ? -49.328 17.684  -20.510  1.00 47.99  ? 260  THR B CB  1 
ATOM   2274 O OG1 . THR C 2 248 ? -49.153 18.983  -19.928  1.00 49.57  ? 260  THR B OG1 1 
ATOM   2275 C CG2 . THR C 2 248 ? -48.215 16.767  -20.032  1.00 48.60  ? 260  THR B CG2 1 
ATOM   2276 N N   . THR C 2 249 ? -50.842 19.007  -23.520  1.00 42.80  ? 261  THR B N   1 
ATOM   2277 C CA  . THR C 2 249 ? -52.166 19.465  -23.932  1.00 45.36  ? 261  THR B CA  1 
ATOM   2278 C C   . THR C 2 249 ? -52.977 18.330  -24.547  1.00 44.81  ? 261  THR B C   1 
ATOM   2279 O O   . THR C 2 249 ? -54.152 18.138  -24.214  1.00 49.48  ? 261  THR B O   1 
ATOM   2280 C CB  . THR C 2 249 ? -52.035 20.633  -24.916  1.00 46.65  ? 261  THR B CB  1 
ATOM   2281 O OG1 . THR C 2 249 ? -51.708 21.829  -24.196  1.00 46.18  ? 261  THR B OG1 1 
ATOM   2282 C CG2 . THR C 2 249 ? -53.338 20.852  -25.678  1.00 44.82  ? 261  THR B CG2 1 
ATOM   2283 N N   . PHE C 2 250 ? -52.361 17.556  -25.439  1.00 45.92  ? 262  PHE B N   1 
ATOM   2284 C CA  . PHE C 2 250 ? -53.053 16.492  -26.153  1.00 51.47  ? 262  PHE B CA  1 
ATOM   2285 C C   . PHE C 2 250 ? -52.819 15.121  -25.530  1.00 55.18  ? 262  PHE B C   1 
ATOM   2286 O O   . PHE C 2 250 ? -53.005 14.102  -26.203  1.00 59.14  ? 262  PHE B O   1 
ATOM   2287 C CB  . PHE C 2 250 ? -52.627 16.490  -27.622  1.00 40.77  ? 262  PHE B CB  1 
ATOM   2288 C CG  . PHE C 2 250 ? -53.075 17.705  -28.382  1.00 34.18  ? 262  PHE B CG  1 
ATOM   2289 C CD1 . PHE C 2 250 ? -54.421 18.029  -28.465  1.00 33.35  ? 262  PHE B CD1 1 
ATOM   2290 C CD2 . PHE C 2 250 ? -52.151 18.526  -29.009  1.00 27.73  ? 262  PHE B CD2 1 
ATOM   2291 C CE1 . PHE C 2 250 ? -54.839 19.147  -29.163  1.00 27.45  ? 262  PHE B CE1 1 
ATOM   2292 C CE2 . PHE C 2 250 ? -52.563 19.646  -29.710  1.00 45.38  ? 262  PHE B CE2 1 
ATOM   2293 C CZ  . PHE C 2 250 ? -53.911 19.957  -29.786  1.00 39.40  ? 262  PHE B CZ  1 
ATOM   2294 N N   . ALA C 2 251 ? -52.432 15.076  -24.254  1.00 61.97  ? 263  ALA B N   1 
ATOM   2295 C CA  . ALA C 2 251 ? -52.061 13.808  -23.634  1.00 48.53  ? 263  ALA B CA  1 
ATOM   2296 C C   . ALA C 2 251 ? -53.282 12.929  -23.391  1.00 39.08  ? 263  ALA B C   1 
ATOM   2297 O O   . ALA C 2 251 ? -53.279 11.738  -23.727  1.00 35.74  ? 263  ALA B O   1 
ATOM   2298 C CB  . ALA C 2 251 ? -51.314 14.067  -22.326  1.00 34.95  ? 263  ALA B CB  1 
ATOM   2299 N N   . GLN C 2 252 ? -54.335 13.501  -22.805  1.00 37.42  ? 264  GLN B N   1 
ATOM   2300 C CA  . GLN C 2 252 ? -55.527 12.719  -22.492  1.00 44.13  ? 264  GLN B CA  1 
ATOM   2301 C C   . GLN C 2 252 ? -56.164 12.143  -23.753  1.00 61.34  ? 264  GLN B C   1 
ATOM   2302 O O   . GLN C 2 252 ? -56.608 10.989  -23.760  1.00 50.86  ? 264  GLN B O   1 
ATOM   2303 C CB  . GLN C 2 252 ? -56.533 13.582  -21.730  1.00 38.48  ? 264  GLN B CB  1 
ATOM   2304 C CG  . GLN C 2 252 ? -56.547 13.343  -20.234  1.00 43.19  ? 264  GLN B CG  1 
ATOM   2305 C CD  . GLN C 2 252 ? -57.025 11.950  -19.874  1.00 64.70  ? 264  GLN B CD  1 
ATOM   2306 O OE1 . GLN C 2 252 ? -58.226 11.676  -19.868  1.00 75.98  ? 264  GLN B OE1 1 
ATOM   2307 N NE2 . GLN C 2 252 ? -56.085 11.062  -19.569  1.00 57.32  ? 264  GLN B NE2 1 
ATOM   2308 N N   . VAL C 2 253 ? -56.210 12.930  -24.832  1.00 62.66  ? 265  VAL B N   1 
ATOM   2309 C CA  . VAL C 2 253 ? -56.880 12.486  -26.051  1.00 54.19  ? 265  VAL B CA  1 
ATOM   2310 C C   . VAL C 2 253 ? -56.100 11.356  -26.715  1.00 62.95  ? 265  VAL B C   1 
ATOM   2311 O O   . VAL C 2 253 ? -56.687 10.398  -27.237  1.00 51.03  ? 265  VAL B O   1 
ATOM   2312 C CB  . VAL C 2 253 ? -57.084 13.679  -27.005  1.00 44.38  ? 265  VAL B CB  1 
ATOM   2313 C CG1 . VAL C 2 253 ? -57.387 13.204  -28.424  1.00 56.95  ? 265  VAL B CG1 1 
ATOM   2314 C CG2 . VAL C 2 253 ? -58.198 14.577  -26.492  1.00 42.07  ? 265  VAL B CG2 1 
ATOM   2315 N N   . LEU C 2 254 ? -54.774 11.435  -26.690  1.00 54.46  ? 266  LEU B N   1 
ATOM   2316 C CA  . LEU C 2 254 ? -53.927 10.468  -27.371  1.00 48.61  ? 266  LEU B CA  1 
ATOM   2317 C C   . LEU C 2 254 ? -53.585 9.260   -26.509  1.00 48.84  ? 266  LEU B C   1 
ATOM   2318 O O   . LEU C 2 254 ? -52.761 8.443   -26.923  1.00 58.30  ? 266  LEU B O   1 
ATOM   2319 C CB  . LEU C 2 254 ? -52.638 11.143  -27.843  1.00 45.62  ? 266  LEU B CB  1 
ATOM   2320 C CG  . LEU C 2 254 ? -52.789 12.249  -28.888  1.00 53.11  ? 266  LEU B CG  1 
ATOM   2321 C CD1 . LEU C 2 254 ? -51.438 12.880  -29.185  1.00 54.62  ? 266  LEU B CD1 1 
ATOM   2322 C CD2 . LEU C 2 254 ? -53.431 11.713  -30.163  1.00 46.86  ? 266  LEU B CD2 1 
ATOM   2323 N N   . LYS C 2 255 ? -54.207 9.119   -25.335  1.00 50.25  ? 267  LYS B N   1 
ATOM   2324 C CA  . LYS C 2 255 ? -53.810 8.060   -24.411  1.00 56.17  ? 267  LYS B CA  1 
ATOM   2325 C C   . LYS C 2 255 ? -53.971 6.671   -25.021  1.00 48.44  ? 267  LYS B C   1 
ATOM   2326 O O   . LYS C 2 255 ? -53.267 5.736   -24.621  1.00 47.06  ? 267  LYS B O   1 
ATOM   2327 C CB  . LYS C 2 255 ? -54.618 8.158   -23.115  1.00 60.57  ? 267  LYS B CB  1 
ATOM   2328 C CG  . LYS C 2 255 ? -56.080 7.750   -23.253  1.00 59.37  ? 267  LYS B CG  1 
ATOM   2329 C CD  . LYS C 2 255 ? -56.832 7.906   -21.939  1.00 64.33  ? 267  LYS B CD  1 
ATOM   2330 C CE  . LYS C 2 255 ? -57.781 6.738   -21.695  1.00 56.32  ? 267  LYS B CE  1 
ATOM   2331 N NZ  . LYS C 2 255 ? -57.177 5.683   -20.830  1.00 53.26  ? 267  LYS B NZ  1 
ATOM   2332 N N   . ASP C 2 256 ? -54.877 6.513   -25.987  1.00 44.62  ? 268  ASP B N   1 
ATOM   2333 C CA  . ASP C 2 256 ? -55.174 5.203   -26.554  1.00 50.52  ? 268  ASP B CA  1 
ATOM   2334 C C   . ASP C 2 256 ? -54.901 5.123   -28.052  1.00 54.99  ? 268  ASP B C   1 
ATOM   2335 O O   . ASP C 2 256 ? -55.299 4.141   -28.692  1.00 62.79  ? 268  ASP B O   1 
ATOM   2336 C CB  . ASP C 2 256 ? -56.630 4.821   -26.262  1.00 48.25  ? 268  ASP B CB  1 
ATOM   2337 C CG  . ASP C 2 256 ? -56.825 4.285   -24.850  1.00 59.38  ? 268  ASP B CG  1 
ATOM   2338 O OD1 . ASP C 2 256 ? -55.847 4.278   -24.070  1.00 66.52  ? 268  ASP B OD1 1 
ATOM   2339 O OD2 . ASP C 2 256 ? -57.957 3.871   -24.517  1.00 51.62  ? 268  ASP B OD2 1 
ATOM   2340 N N   . ASP C 2 257 ? -54.226 6.117   -28.628  1.00 54.99  ? 269  ASP B N   1 
ATOM   2341 C CA  . ASP C 2 257 ? -53.901 6.129   -30.056  1.00 48.00  ? 269  ASP B CA  1 
ATOM   2342 C C   . ASP C 2 257 ? -52.418 5.803   -30.195  1.00 48.36  ? 269  ASP B C   1 
ATOM   2343 O O   . ASP C 2 257 ? -51.566 6.692   -30.213  1.00 56.34  ? 269  ASP B O   1 
ATOM   2344 C CB  . ASP C 2 257 ? -54.247 7.475   -30.680  1.00 48.29  ? 269  ASP B CB  1 
ATOM   2345 C CG  . ASP C 2 257 ? -54.279 7.425   -32.194  1.00 45.25  ? 269  ASP B CG  1 
ATOM   2346 O OD1 . ASP C 2 257 ? -53.898 6.383   -32.770  1.00 53.28  ? 269  ASP B OD1 1 
ATOM   2347 O OD2 . ASP C 2 257 ? -54.682 8.435   -32.808  1.00 41.78  ? 269  ASP B OD2 1 
ATOM   2348 N N   . THR C 2 258 ? -52.115 4.508   -30.308  1.00 47.73  ? 270  THR B N   1 
ATOM   2349 C CA  . THR C 2 258 ? -50.724 4.062   -30.317  1.00 47.65  ? 270  THR B CA  1 
ATOM   2350 C C   . THR C 2 258 ? -49.961 4.630   -31.507  1.00 45.40  ? 270  THR B C   1 
ATOM   2351 O O   . THR C 2 258 ? -48.831 5.110   -31.362  1.00 48.69  ? 270  THR B O   1 
ATOM   2352 C CB  . THR C 2 258 ? -50.669 2.536   -30.331  1.00 53.53  ? 270  THR B CB  1 
ATOM   2353 O OG1 . THR C 2 258 ? -51.417 2.021   -29.223  1.00 48.60  ? 270  THR B OG1 1 
ATOM   2354 C CG2 . THR C 2 258 ? -49.228 2.056   -30.243  1.00 54.01  ? 270  THR B CG2 1 
ATOM   2355 N N   . THR C 2 259 ? -50.565 4.578   -32.695  1.00 47.47  ? 271  THR B N   1 
ATOM   2356 C CA  . THR C 2 259 ? -49.866 5.024   -33.896  1.00 46.92  ? 271  THR B CA  1 
ATOM   2357 C C   . THR C 2 259 ? -49.565 6.519   -33.844  1.00 40.82  ? 271  THR B C   1 
ATOM   2358 O O   . THR C 2 259 ? -48.497 6.957   -34.286  1.00 46.39  ? 271  THR B O   1 
ATOM   2359 C CB  . THR C 2 259 ? -50.688 4.678   -35.138  1.00 46.66  ? 271  THR B CB  1 
ATOM   2360 O OG1 . THR C 2 259 ? -52.019 5.190   -34.993  1.00 56.93  ? 271  THR B OG1 1 
ATOM   2361 C CG2 . THR C 2 259 ? -50.750 3.168   -35.322  1.00 55.62  ? 271  THR B CG2 1 
ATOM   2362 N N   . THR C 2 260 ? -50.487 7.317   -33.299  1.00 39.71  ? 272  THR B N   1 
ATOM   2363 C CA  . THR C 2 260 ? -50.253 8.757   -33.226  1.00 40.99  ? 272  THR B CA  1 
ATOM   2364 C C   . THR C 2 260 ? -49.201 9.095   -32.176  1.00 53.01  ? 272  THR B C   1 
ATOM   2365 O O   . THR C 2 260 ? -48.360 9.976   -32.396  1.00 49.57  ? 272  THR B O   1 
ATOM   2366 C CB  . THR C 2 260 ? -51.557 9.496   -32.929  1.00 34.88  ? 272  THR B CB  1 
ATOM   2367 O OG1 . THR C 2 260 ? -52.543 9.130   -33.900  1.00 42.17  ? 272  THR B OG1 1 
ATOM   2368 C CG2 . THR C 2 260 ? -51.337 11.003  -32.984  1.00 24.57  ? 272  THR B CG2 1 
ATOM   2369 N N   . LYS C 2 261 ? -49.238 8.413   -31.027  1.00 53.81  ? 273  LYS B N   1 
ATOM   2370 C CA  . LYS C 2 261 ? -48.221 8.629   -30.004  1.00 33.29  ? 273  LYS B CA  1 
ATOM   2371 C C   . LYS C 2 261 ? -46.826 8.381   -30.559  1.00 41.19  ? 273  LYS B C   1 
ATOM   2372 O O   . LYS C 2 261 ? -45.886 9.128   -30.262  1.00 51.74  ? 273  LYS B O   1 
ATOM   2373 C CB  . LYS C 2 261 ? -48.477 7.718   -28.803  1.00 34.63  ? 273  LYS B CB  1 
ATOM   2374 C CG  . LYS C 2 261 ? -49.719 8.051   -27.998  1.00 33.87  ? 273  LYS B CG  1 
ATOM   2375 C CD  . LYS C 2 261 ? -50.274 6.804   -27.317  1.00 47.06  ? 273  LYS B CD  1 
ATOM   2376 C CE  . LYS C 2 261 ? -49.550 6.491   -26.018  1.00 54.36  ? 273  LYS B CE  1 
ATOM   2377 N NZ  . LYS C 2 261 ? -50.233 5.405   -25.256  1.00 53.20  ? 273  LYS B NZ  1 
ATOM   2378 N N   . ARG C 2 262 ? -46.676 7.336   -31.375  1.00 38.00  ? 274  ARG B N   1 
ATOM   2379 C CA  . ARG C 2 262 ? -45.369 7.003   -31.928  1.00 38.40  ? 274  ARG B CA  1 
ATOM   2380 C C   . ARG C 2 262 ? -44.907 8.055   -32.927  1.00 50.64  ? 274  ARG B C   1 
ATOM   2381 O O   . ARG C 2 262 ? -43.735 8.453   -32.919  1.00 52.71  ? 274  ARG B O   1 
ATOM   2382 C CB  . ARG C 2 262 ? -45.424 5.621   -32.576  1.00 50.38  ? 274  ARG B CB  1 
ATOM   2383 C CG  . ARG C 2 262 ? -44.285 5.313   -33.526  1.00 61.02  ? 274  ARG B CG  1 
ATOM   2384 C CD  . ARG C 2 262 ? -44.754 4.348   -34.597  1.00 59.93  ? 274  ARG B CD  1 
ATOM   2385 N NE  . ARG C 2 262 ? -45.638 3.330   -34.040  1.00 59.80  ? 274  ARG B NE  1 
ATOM   2386 C CZ  . ARG C 2 262 ? -46.203 2.359   -34.745  1.00 82.30  ? 274  ARG B CZ  1 
ATOM   2387 N NH1 . ARG C 2 262 ? -45.995 2.238   -36.046  1.00 85.27  ? 274  ARG B NH1 1 
ATOM   2388 N NH2 . ARG C 2 262 ? -46.997 1.487   -34.129  1.00 92.21  ? 274  ARG B NH2 1 
ATOM   2389 N N   . TRP C 2 263 ? -45.816 8.519   -33.790  1.00 50.56  ? 275  TRP B N   1 
ATOM   2390 C CA  . TRP C 2 263 ? -45.470 9.556   -34.758  1.00 35.00  ? 275  TRP B CA  1 
ATOM   2391 C C   . TRP C 2 263 ? -45.020 10.831  -34.057  1.00 43.43  ? 275  TRP B C   1 
ATOM   2392 O O   . TRP C 2 263 ? -43.983 11.411  -34.400  1.00 43.87  ? 275  TRP B O   1 
ATOM   2393 C CB  . TRP C 2 263 ? -46.662 9.842   -35.671  1.00 22.65  ? 275  TRP B CB  1 
ATOM   2394 C CG  . TRP C 2 263 ? -46.965 8.750   -36.644  1.00 27.28  ? 275  TRP B CG  1 
ATOM   2395 C CD1 . TRP C 2 263 ? -46.151 7.712   -36.995  1.00 35.24  ? 275  TRP B CD1 1 
ATOM   2396 C CD2 . TRP C 2 263 ? -48.173 8.587   -37.402  1.00 31.96  ? 275  TRP B CD2 1 
ATOM   2397 N NE1 . TRP C 2 263 ? -46.778 6.911   -37.921  1.00 34.15  ? 275  TRP B NE1 1 
ATOM   2398 C CE2 . TRP C 2 263 ? -48.019 7.427   -38.188  1.00 25.70  ? 275  TRP B CE2 1 
ATOM   2399 C CE3 . TRP C 2 263 ? -49.368 9.309   -37.490  1.00 30.30  ? 275  TRP B CE3 1 
ATOM   2400 C CZ2 . TRP C 2 263 ? -49.015 6.972   -39.050  1.00 25.06  ? 275  TRP B CZ2 1 
ATOM   2401 C CZ3 . TRP C 2 263 ? -50.356 8.856   -38.346  1.00 26.26  ? 275  TRP B CZ3 1 
ATOM   2402 C CH2 . TRP C 2 263 ? -50.173 7.699   -39.115  1.00 29.29  ? 275  TRP B CH2 1 
ATOM   2403 N N   . LEU C 2 264 ? -45.800 11.288  -33.073  1.00 40.45  ? 276  LEU B N   1 
ATOM   2404 C CA  . LEU C 2 264 ? -45.411 12.472  -32.315  1.00 37.17  ? 276  LEU B CA  1 
ATOM   2405 C C   . LEU C 2 264 ? -44.079 12.254  -31.612  1.00 44.45  ? 276  LEU B C   1 
ATOM   2406 O O   . LEU C 2 264 ? -43.226 13.149  -31.590  1.00 45.08  ? 276  LEU B O   1 
ATOM   2407 C CB  . LEU C 2 264 ? -46.498 12.831  -31.303  1.00 25.23  ? 276  LEU B CB  1 
ATOM   2408 C CG  . LEU C 2 264 ? -46.388 14.196  -30.615  1.00 32.62  ? 276  LEU B CG  1 
ATOM   2409 C CD1 . LEU C 2 264 ? -45.740 15.235  -31.522  1.00 43.89  ? 276  LEU B CD1 1 
ATOM   2410 C CD2 . LEU C 2 264 ? -47.752 14.674  -30.148  1.00 41.84  ? 276  LEU B CD2 1 
ATOM   2411 N N   . ALA C 2 265 ? -43.884 11.065  -31.038  1.00 50.48  ? 277  ALA B N   1 
ATOM   2412 C CA  . ALA C 2 265 ? -42.620 10.753  -30.381  1.00 52.06  ? 277  ALA B CA  1 
ATOM   2413 C C   . ALA C 2 265 ? -41.451 10.916  -31.342  1.00 55.35  ? 277  ALA B C   1 
ATOM   2414 O O   . ALA C 2 265 ? -40.460 11.586  -31.026  1.00 59.98  ? 277  ALA B O   1 
ATOM   2415 C CB  . ALA C 2 265 ? -42.661 9.333   -29.815  1.00 54.75  ? 277  ALA B CB  1 
ATOM   2416 N N   . GLN C 2 266 ? -41.561 10.326  -32.535  1.00 45.10  ? 278  GLN B N   1 
ATOM   2417 C CA  . GLN C 2 266 ? -40.492 10.443  -33.520  1.00 55.14  ? 278  GLN B CA  1 
ATOM   2418 C C   . GLN C 2 266 ? -40.290 11.894  -33.942  1.00 56.54  ? 278  GLN B C   1 
ATOM   2419 O O   . GLN C 2 266 ? -39.153 12.339  -34.138  1.00 54.19  ? 278  GLN B O   1 
ATOM   2420 C CB  . GLN C 2 266 ? -40.807 9.564   -34.733  1.00 39.62  ? 278  GLN B CB  1 
ATOM   2421 C CG  . GLN C 2 266 ? -39.759 8.503   -35.074  1.00 37.73  ? 278  GLN B CG  1 
ATOM   2422 C CD  . GLN C 2 266 ? -38.434 9.063   -35.573  1.00 75.23  ? 278  GLN B CD  1 
ATOM   2423 O OE1 . GLN C 2 266 ? -38.167 10.260  -35.490  1.00 82.41  ? 278  GLN B OE1 1 
ATOM   2424 N NE2 . GLN C 2 266 ? -37.593 8.182   -36.102  1.00 91.15  ? 278  GLN B NE2 1 
ATOM   2425 N N   . LEU C 2 267 ? -41.384 12.652  -34.071  1.00 51.98  ? 279  LEU B N   1 
ATOM   2426 C CA  . LEU C 2 267 ? -41.281 14.037  -34.527  1.00 56.46  ? 279  LEU B CA  1 
ATOM   2427 C C   . LEU C 2 267 ? -40.381 14.854  -33.607  1.00 66.43  ? 279  LEU B C   1 
ATOM   2428 O O   . LEU C 2 267 ? -39.483 15.567  -34.070  1.00 69.56  ? 279  LEU B O   1 
ATOM   2429 C CB  . LEU C 2 267 ? -42.671 14.667  -34.620  1.00 43.53  ? 279  LEU B CB  1 
ATOM   2430 C CG  . LEU C 2 267 ? -42.716 16.199  -34.641  1.00 33.51  ? 279  LEU B CG  1 
ATOM   2431 C CD1 . LEU C 2 267 ? -42.076 16.742  -35.909  1.00 41.88  ? 279  LEU B CD1 1 
ATOM   2432 C CD2 . LEU C 2 267 ? -44.145 16.700  -34.508  1.00 28.98  ? 279  LEU B CD2 1 
ATOM   2433 N N   . VAL C 2 268 ? -40.604 14.756  -32.295  1.00 59.00  ? 280  VAL B N   1 
ATOM   2434 C CA  . VAL C 2 268 ? -39.758 15.480  -31.354  1.00 50.14  ? 280  VAL B CA  1 
ATOM   2435 C C   . VAL C 2 268 ? -38.339 14.928  -31.378  1.00 50.48  ? 280  VAL B C   1 
ATOM   2436 O O   . VAL C 2 268 ? -37.365 15.678  -31.244  1.00 55.27  ? 280  VAL B O   1 
ATOM   2437 C CB  . VAL C 2 268 ? -40.365 15.432  -29.941  1.00 40.55  ? 280  VAL B CB  1 
ATOM   2438 C CG1 . VAL C 2 268 ? -39.776 16.536  -29.078  1.00 45.01  ? 280  VAL B CG1 1 
ATOM   2439 C CG2 . VAL C 2 268 ? -41.876 15.560  -30.014  1.00 37.77  ? 280  VAL B CG2 1 
ATOM   2440 N N   . LYS C 2 269 ? -38.194 13.612  -31.557  1.00 43.39  ? 281  LYS B N   1 
ATOM   2441 C CA  . LYS C 2 269 ? -36.860 13.039  -31.694  1.00 50.55  ? 281  LYS B CA  1 
ATOM   2442 C C   . LYS C 2 269 ? -36.189 13.485  -32.986  1.00 70.83  ? 281  LYS B C   1 
ATOM   2443 O O   . LYS C 2 269 ? -34.964 13.648  -33.021  1.00 85.07  ? 281  LYS B O   1 
ATOM   2444 C CB  . LYS C 2 269 ? -36.923 11.513  -31.634  1.00 44.61  ? 281  LYS B CB  1 
ATOM   2445 C CG  . LYS C 2 269 ? -37.539 10.961  -30.361  1.00 75.09  ? 281  LYS B CG  1 
ATOM   2446 C CD  . LYS C 2 269 ? -36.660 9.895   -29.730  1.00 88.42  ? 281  LYS B CD  1 
ATOM   2447 C CE  . LYS C 2 269 ? -36.739 9.947   -28.212  1.00 82.05  ? 281  LYS B CE  1 
ATOM   2448 N NZ  . LYS C 2 269 ? -35.755 10.908  -27.635  1.00 72.32  ? 281  LYS B NZ  1 
ATOM   2449 N N   . ASN C 2 270 ? -36.968 13.688  -34.052  1.00 66.42  ? 282  ASN B N   1 
ATOM   2450 C CA  . ASN C 2 270 ? -36.384 14.100  -35.325  1.00 67.76  ? 282  ASN B CA  1 
ATOM   2451 C C   . ASN C 2 270 ? -35.772 15.491  -35.228  1.00 71.40  ? 282  ASN B C   1 
ATOM   2452 O O   . ASN C 2 270 ? -34.666 15.726  -35.731  1.00 74.42  ? 282  ASN B O   1 
ATOM   2453 C CB  . ASN C 2 270 ? -37.442 14.051  -36.427  1.00 66.43  ? 282  ASN B CB  1 
ATOM   2454 C CG  . ASN C 2 270 ? -37.395 12.759  -37.222  1.00 76.81  ? 282  ASN B CG  1 
ATOM   2455 O OD1 . ASN C 2 270 ? -36.479 11.953  -37.063  1.00 79.59  ? 282  ASN B OD1 1 
ATOM   2456 N ND2 . ASN C 2 270 ? -38.384 12.558  -38.086  1.00 75.87  ? 282  ASN B ND2 1 
ATOM   2457 N N   . LEU C 2 271 ? -36.469 16.422  -34.580  1.00 64.15  ? 283  LEU B N   1 
ATOM   2458 C CA  . LEU C 2 271 ? -35.969 17.779  -34.404  1.00 67.92  ? 283  LEU B CA  1 
ATOM   2459 C C   . LEU C 2 271 ? -34.891 17.879  -33.333  1.00 82.05  ? 283  LEU B C   1 
ATOM   2460 O O   . LEU C 2 271 ? -34.320 18.960  -33.155  1.00 86.87  ? 283  LEU B O   1 
ATOM   2461 C CB  . LEU C 2 271 ? -37.127 18.719  -34.053  1.00 57.65  ? 283  LEU B CB  1 
ATOM   2462 C CG  . LEU C 2 271 ? -38.304 18.746  -35.029  1.00 53.79  ? 283  LEU B CG  1 
ATOM   2463 C CD1 . LEU C 2 271 ? -39.360 19.749  -34.584  1.00 42.72  ? 283  LEU B CD1 1 
ATOM   2464 C CD2 . LEU C 2 271 ? -37.828 19.054  -36.439  1.00 55.56  ? 283  LEU B CD2 1 
ATOM   2465 N N   . GLN C 2 272 ? -34.597 16.788  -32.629  1.00 84.13  ? 284  GLN B N   1 
ATOM   2466 C CA  . GLN C 2 272 ? -33.675 16.841  -31.502  1.00 92.26  ? 284  GLN B CA  1 
ATOM   2467 C C   . GLN C 2 272 ? -32.249 17.088  -31.977  1.00 100.85 ? 284  GLN B C   1 
ATOM   2468 O O   . GLN C 2 272 ? -31.762 16.424  -32.899  1.00 102.79 ? 284  GLN B O   1 
ATOM   2469 C CB  . GLN C 2 272 ? -33.749 15.543  -30.699  1.00 101.44 ? 284  GLN B CB  1 
ATOM   2470 C CG  . GLN C 2 272 ? -32.446 15.140  -30.027  1.00 100.23 ? 284  GLN B CG  1 
ATOM   2471 C CD  . GLN C 2 272 ? -32.495 13.734  -29.464  1.00 105.16 ? 284  GLN B CD  1 
ATOM   2472 O OE1 . GLN C 2 272 ? -33.187 13.469  -28.480  1.00 105.42 ? 284  GLN B OE1 1 
ATOM   2473 N NE2 . GLN C 2 272 ? -31.761 12.821  -30.091  1.00 100.28 ? 284  GLN B NE2 1 
ATOM   2474 N N   . GLU C 2 273 ? -31.584 18.048  -31.342  1.00 111.81 ? 285  GLU B N   1 
ATOM   2475 C CA  . GLU C 2 273 ? -30.185 18.349  -31.618  1.00 130.82 ? 285  GLU B CA  1 
ATOM   2476 C C   . GLU C 2 273 ? -29.588 19.119  -30.442  1.00 138.68 ? 285  GLU B C   1 
ATOM   2477 O O   . GLU C 2 273 ? -28.396 19.023  -30.152  1.00 138.13 ? 285  GLU B O   1 
ATOM   2478 C CB  . GLU C 2 273 ? -30.043 19.149  -32.917  1.00 124.97 ? 285  GLU B CB  1 
ATOM   2479 C CG  . GLU C 2 273 ? -28.610 19.286  -33.421  1.00 131.75 ? 285  GLU B CG  1 
ATOM   2480 C CD  . GLU C 2 273 ? -27.908 20.516  -32.877  1.00 133.30 ? 285  GLU B CD  1 
ATOM   2481 O OE1 . GLU C 2 273 ? -28.602 21.503  -32.552  1.00 153.14 ? 285  GLU B OE1 1 
ATOM   2482 O OE2 . GLU C 2 273 ? -26.663 20.496  -32.776  1.00 117.60 ? 285  GLU B OE2 1 
ATOM   2483 O OXT . GLU C 2 273 ? -30.293 19.851  -29.746  1.00 139.09 ? 285  GLU B OXT 1 
ATOM   2484 N N   . GLN D 3 10  ? -81.205 33.986  -60.823  1.00 57.96  ? 1354 GLN A N   1 
ATOM   2485 C CA  . GLN D 3 10  ? -81.790 34.176  -62.145  1.00 54.92  ? 1354 GLN A CA  1 
ATOM   2486 C C   . GLN D 3 10  ? -80.904 35.063  -63.019  1.00 63.85  ? 1354 GLN A C   1 
ATOM   2487 O O   . GLN D 3 10  ? -80.501 36.152  -62.606  1.00 60.94  ? 1354 GLN A O   1 
ATOM   2488 C CB  . GLN D 3 10  ? -83.194 34.776  -62.028  1.00 71.71  ? 1354 GLN A CB  1 
ATOM   2489 C CG  . GLN D 3 10  ? -83.265 36.043  -61.184  1.00 83.74  ? 1354 GLN A CG  1 
ATOM   2490 C CD  . GLN D 3 10  ? -84.552 36.817  -61.395  1.00 79.20  ? 1354 GLN A CD  1 
ATOM   2491 O OE1 . GLN D 3 10  ? -84.836 37.290  -62.498  1.00 62.17  ? 1354 GLN A OE1 1 
ATOM   2492 N NE2 . GLN D 3 10  ? -85.338 36.953  -60.334  1.00 62.36  ? 1354 GLN A NE2 1 
ATOM   2493 N N   . PRO D 3 11  ? -80.593 34.594  -64.228  1.00 62.96  ? 1355 PRO A N   1 
ATOM   2494 C CA  . PRO D 3 11  ? -79.728 35.378  -65.121  1.00 43.59  ? 1355 PRO A CA  1 
ATOM   2495 C C   . PRO D 3 11  ? -80.464 36.596  -65.662  1.00 50.17  ? 1355 PRO A C   1 
ATOM   2496 O O   . PRO D 3 11  ? -81.573 36.487  -66.191  1.00 58.45  ? 1355 PRO A O   1 
ATOM   2497 C CB  . PRO D 3 11  ? -79.371 34.386  -66.234  1.00 37.17  ? 1355 PRO A CB  1 
ATOM   2498 C CG  . PRO D 3 11  ? -80.480 33.390  -66.227  1.00 35.86  ? 1355 PRO A CG  1 
ATOM   2499 C CD  . PRO D 3 11  ? -80.969 33.293  -64.809  1.00 66.16  ? 1355 PRO A CD  1 
ATOM   2500 N N   . GLN D 3 12  ? -79.832 37.763  -65.525  1.00 51.15  ? 1356 GLN A N   1 
ATOM   2501 C CA  . GLN D 3 12  ? -80.465 39.010  -65.943  1.00 48.06  ? 1356 GLN A CA  1 
ATOM   2502 C C   . GLN D 3 12  ? -80.319 39.250  -67.440  1.00 43.71  ? 1356 GLN A C   1 
ATOM   2503 O O   . GLN D 3 12  ? -81.277 39.672  -68.097  1.00 51.22  ? 1356 GLN A O   1 
ATOM   2504 C CB  . GLN D 3 12  ? -79.874 40.187  -65.165  1.00 48.84  ? 1356 GLN A CB  1 
ATOM   2505 C CG  . GLN D 3 12  ? -80.655 41.487  -65.300  1.00 42.30  ? 1356 GLN A CG  1 
ATOM   2506 C CD  . GLN D 3 12  ? -80.310 42.488  -64.210  1.00 58.52  ? 1356 GLN A CD  1 
ATOM   2507 O OE1 . GLN D 3 12  ? -79.214 42.459  -63.649  1.00 50.62  ? 1356 GLN A OE1 1 
ATOM   2508 N NE2 . GLN D 3 12  ? -81.247 43.382  -63.907  1.00 64.72  ? 1356 GLN A NE2 1 
ATOM   2509 N N   . TYR D 3 13  ? -79.141 38.988  -67.995  1.00 40.99  ? 1357 TYR A N   1 
ATOM   2510 C CA  . TYR D 3 13  ? -78.813 39.388  -69.355  1.00 34.64  ? 1357 TYR A CA  1 
ATOM   2511 C C   . TYR D 3 13  ? -78.761 38.188  -70.291  1.00 40.05  ? 1357 TYR A C   1 
ATOM   2512 O O   . TYR D 3 13  ? -78.830 37.027  -69.878  1.00 42.50  ? 1357 TYR A O   1 
ATOM   2513 C CB  . TYR D 3 13  ? -77.470 40.123  -69.396  1.00 28.72  ? 1357 TYR A CB  1 
ATOM   2514 C CG  . TYR D 3 13  ? -77.342 41.230  -68.381  1.00 32.02  ? 1357 TYR A CG  1 
ATOM   2515 C CD1 . TYR D 3 13  ? -77.844 42.497  -68.642  1.00 40.66  ? 1357 TYR A CD1 1 
ATOM   2516 C CD2 . TYR D 3 13  ? -76.710 41.013  -67.165  1.00 33.68  ? 1357 TYR A CD2 1 
ATOM   2517 C CE1 . TYR D 3 13  ? -77.724 43.519  -67.719  1.00 44.90  ? 1357 TYR A CE1 1 
ATOM   2518 C CE2 . TYR D 3 13  ? -76.586 42.030  -66.233  1.00 43.98  ? 1357 TYR A CE2 1 
ATOM   2519 C CZ  . TYR D 3 13  ? -77.095 43.281  -66.517  1.00 37.91  ? 1357 TYR A CZ  1 
ATOM   2520 O OH  . TYR D 3 13  ? -76.979 44.300  -65.599  1.00 42.58  ? 1357 TYR A OH  1 
ATOM   2521 N N   . SER D 3 14  ? -78.636 38.503  -71.576  1.00 51.75  ? 1358 SER A N   1 
ATOM   2522 C CA  . SER D 3 14  ? -78.371 37.539  -72.629  1.00 42.22  ? 1358 SER A CA  1 
ATOM   2523 C C   . SER D 3 14  ? -77.034 37.870  -73.277  1.00 39.50  ? 1358 SER A C   1 
ATOM   2524 O O   . SER D 3 14  ? -76.490 38.965  -73.106  1.00 40.04  ? 1358 SER A O   1 
ATOM   2525 C CB  . SER D 3 14  ? -79.482 37.541  -73.685  1.00 34.52  ? 1358 SER A CB  1 
ATOM   2526 O OG  . SER D 3 14  ? -79.410 36.382  -74.496  1.00 63.79  ? 1358 SER A OG  1 
ATOM   2527 N N   . TYR D 3 15  ? -76.504 36.901  -74.025  1.00 29.42  ? 1359 TYR A N   1 
ATOM   2528 C CA  . TYR D 3 15  ? -75.193 37.084  -74.640  1.00 31.15  ? 1359 TYR A CA  1 
ATOM   2529 C C   . TYR D 3 15  ? -75.191 38.274  -75.591  1.00 42.51  ? 1359 TYR A C   1 
ATOM   2530 O O   . TYR D 3 15  ? -74.211 39.028  -75.658  1.00 43.35  ? 1359 TYR A O   1 
ATOM   2531 C CB  . TYR D 3 15  ? -74.775 35.788  -75.340  1.00 47.64  ? 1359 TYR A CB  1 
ATOM   2532 C CG  . TYR D 3 15  ? -73.295 35.702  -75.632  1.00 48.49  ? 1359 TYR A CG  1 
ATOM   2533 C CD1 . TYR D 3 15  ? -72.469 34.810  -74.955  1.00 47.53  ? 1359 TYR A CD1 1 
ATOM   2534 C CD2 . TYR D 3 15  ? -72.730 36.487  -76.627  1.00 55.63  ? 1359 TYR A CD2 1 
ATOM   2535 C CE1 . TYR D 3 15  ? -71.104 34.741  -75.241  1.00 47.95  ? 1359 TYR A CE1 1 
ATOM   2536 C CE2 . TYR D 3 15  ? -71.391 36.417  -76.924  1.00 44.78  ? 1359 TYR A CE2 1 
ATOM   2537 C CZ  . TYR D 3 15  ? -70.577 35.555  -76.233  1.00 47.86  ? 1359 TYR A CZ  1 
ATOM   2538 O OH  . TYR D 3 15  ? -69.243 35.536  -76.564  1.00 43.14  ? 1359 TYR A OH  1 
ATOM   2539 N N   . HIS D 3 16  ? -76.296 38.487  -76.298  1.00 43.72  ? 1360 HIS A N   1 
ATOM   2540 C CA  . HIS D 3 16  ? -76.375 39.581  -77.255  1.00 36.52  ? 1360 HIS A CA  1 
ATOM   2541 C C   . HIS D 3 16  ? -76.539 40.939  -76.580  1.00 45.06  ? 1360 HIS A C   1 
ATOM   2542 O O   . HIS D 3 16  ? -76.132 41.959  -77.149  1.00 54.22  ? 1360 HIS A O   1 
ATOM   2543 C CB  . HIS D 3 16  ? -77.535 39.336  -78.214  1.00 29.07  ? 1360 HIS A CB  1 
ATOM   2544 C CG  . HIS D 3 16  ? -77.311 39.896  -79.579  1.00 72.12  ? 1360 HIS A CG  1 
ATOM   2545 N ND1 . HIS D 3 16  ? -78.173 40.797  -80.164  1.00 88.62  ? 1360 HIS A ND1 1 
ATOM   2546 C CD2 . HIS D 3 16  ? -76.321 39.682  -80.477  1.00 81.34  ? 1360 HIS A CD2 1 
ATOM   2547 C CE1 . HIS D 3 16  ? -77.723 41.116  -81.364  1.00 78.43  ? 1360 HIS A CE1 1 
ATOM   2548 N NE2 . HIS D 3 16  ? -76.601 40.453  -81.579  1.00 85.72  ? 1360 HIS A NE2 1 
ATOM   2549 N N   . ASP D 3 17  ? -77.118 40.972  -75.377  1.00 41.76  ? 1361 ASP A N   1 
ATOM   2550 C CA  . ASP D 3 17  ? -77.496 42.243  -74.766  1.00 37.15  ? 1361 ASP A CA  1 
ATOM   2551 C C   . ASP D 3 17  ? -76.291 43.128  -74.487  1.00 39.76  ? 1361 ASP A C   1 
ATOM   2552 O O   . ASP D 3 17  ? -76.393 44.357  -74.577  1.00 49.56  ? 1361 ASP A O   1 
ATOM   2553 C CB  . ASP D 3 17  ? -78.263 41.996  -73.466  1.00 48.12  ? 1361 ASP A CB  1 
ATOM   2554 C CG  . ASP D 3 17  ? -79.681 41.518  -73.703  1.00 68.39  ? 1361 ASP A CG  1 
ATOM   2555 O OD1 . ASP D 3 17  ? -80.056 41.304  -74.876  1.00 75.81  ? 1361 ASP A OD1 1 
ATOM   2556 O OD2 . ASP D 3 17  ? -80.422 41.355  -72.710  1.00 60.35  ? 1361 ASP A OD2 1 
ATOM   2557 N N   . ILE D 3 18  ? -75.155 42.536  -74.142  1.00 38.27  ? 1362 ILE A N   1 
ATOM   2558 C CA  . ILE D 3 18  ? -73.984 43.288  -73.708  1.00 38.23  ? 1362 ILE A CA  1 
ATOM   2559 C C   . ILE D 3 18  ? -72.975 43.353  -74.842  1.00 43.19  ? 1362 ILE A C   1 
ATOM   2560 O O   . ILE D 3 18  ? -72.744 42.360  -75.544  1.00 49.55  ? 1362 ILE A O   1 
ATOM   2561 C CB  . ILE D 3 18  ? -73.366 42.662  -72.446  1.00 28.64  ? 1362 ILE A CB  1 
ATOM   2562 C CG1 . ILE D 3 18  ? -74.472 42.179  -71.511  1.00 28.74  ? 1362 ILE A CG1 1 
ATOM   2563 C CG2 . ILE D 3 18  ? -72.470 43.661  -71.733  1.00 37.86  ? 1362 ILE A CG2 1 
ATOM   2564 C CD1 . ILE D 3 18  ? -73.960 41.660  -70.199  1.00 30.31  ? 1362 ILE A CD1 1 
ATOM   2565 N N   . ASN D 3 19  ? -72.378 44.528  -75.026  1.00 33.75  ? 1363 ASN A N   1 
ATOM   2566 C CA  . ASN D 3 19  ? -71.369 44.759  -76.050  1.00 32.73  ? 1363 ASN A CA  1 
ATOM   2567 C C   . ASN D 3 19  ? -70.005 44.879  -75.385  1.00 32.54  ? 1363 ASN A C   1 
ATOM   2568 O O   . ASN D 3 19  ? -69.859 45.585  -74.381  1.00 33.49  ? 1363 ASN A O   1 
ATOM   2569 C CB  . ASN D 3 19  ? -71.682 46.019  -76.860  1.00 42.12  ? 1363 ASN A CB  1 
ATOM   2570 C CG  . ASN D 3 19  ? -70.617 46.327  -77.894  1.00 50.95  ? 1363 ASN A CG  1 
ATOM   2571 O OD1 . ASN D 3 19  ? -69.989 45.423  -78.445  1.00 48.71  ? 1363 ASN A OD1 1 
ATOM   2572 N ND2 . ASN D 3 19  ? -70.410 47.612  -78.164  1.00 57.14  ? 1363 ASN A ND2 1 
ATOM   2573 N N   . VAL D 3 20  ? -69.010 44.193  -75.951  1.00 32.54  ? 1364 VAL A N   1 
ATOM   2574 C CA  . VAL D 3 20  ? -67.686 44.103  -75.342  1.00 35.51  ? 1364 VAL A CA  1 
ATOM   2575 C C   . VAL D 3 20  ? -66.673 45.021  -76.016  1.00 30.18  ? 1364 VAL A C   1 
ATOM   2576 O O   . VAL D 3 20  ? -65.598 45.266  -75.442  1.00 34.92  ? 1364 VAL A O   1 
ATOM   2577 C CB  . VAL D 3 20  ? -67.199 42.633  -75.349  1.00 28.55  ? 1364 VAL A CB  1 
ATOM   2578 C CG1 . VAL D 3 20  ? -65.781 42.479  -74.797  1.00 24.64  ? 1364 VAL A CG1 1 
ATOM   2579 C CG2 . VAL D 3 20  ? -68.158 41.779  -74.551  1.00 29.11  ? 1364 VAL A CG2 1 
ATOM   2580 N N   . TYR D 3 21  ? -67.001 45.576  -77.187  1.00 25.57  ? 1365 TYR A N   1 
ATOM   2581 C CA  . TYR D 3 21  ? -66.030 46.338  -77.969  1.00 29.59  ? 1365 TYR A CA  1 
ATOM   2582 C C   . TYR D 3 21  ? -65.308 47.379  -77.122  1.00 38.70  ? 1365 TYR A C   1 
ATOM   2583 O O   . TYR D 3 21  ? -64.082 47.511  -77.194  1.00 47.70  ? 1365 TYR A O   1 
ATOM   2584 C CB  . TYR D 3 21  ? -66.722 47.006  -79.157  1.00 53.06  ? 1365 TYR A CB  1 
ATOM   2585 C CG  . TYR D 3 21  ? -65.799 47.892  -79.957  1.00 50.10  ? 1365 TYR A CG  1 
ATOM   2586 C CD1 . TYR D 3 21  ? -64.761 47.352  -80.703  1.00 59.15  ? 1365 TYR A CD1 1 
ATOM   2587 C CD2 . TYR D 3 21  ? -65.956 49.270  -79.955  1.00 56.79  ? 1365 TYR A CD2 1 
ATOM   2588 C CE1 . TYR D 3 21  ? -63.913 48.161  -81.433  1.00 68.03  ? 1365 TYR A CE1 1 
ATOM   2589 C CE2 . TYR D 3 21  ? -65.112 50.086  -80.678  1.00 64.26  ? 1365 TYR A CE2 1 
ATOM   2590 C CZ  . TYR D 3 21  ? -64.092 49.527  -81.414  1.00 61.99  ? 1365 TYR A CZ  1 
ATOM   2591 O OH  . TYR D 3 21  ? -63.249 50.339  -82.137  1.00 67.23  ? 1365 TYR A OH  1 
ATOM   2592 N N   . SER D 3 22  ? -66.052 48.115  -76.299  1.00 49.06  ? 1366 SER A N   1 
ATOM   2593 C CA  . SER D 3 22  ? -65.473 49.115  -75.416  1.00 32.45  ? 1366 SER A CA  1 
ATOM   2594 C C   . SER D 3 22  ? -65.970 48.891  -73.997  1.00 38.35  ? 1366 SER A C   1 
ATOM   2595 O O   . SER D 3 22  ? -66.970 48.207  -73.764  1.00 35.22  ? 1366 SER A O   1 
ATOM   2596 C CB  . SER D 3 22  ? -65.822 50.546  -75.854  1.00 39.63  ? 1366 SER A CB  1 
ATOM   2597 O OG  . SER D 3 22  ? -67.222 50.708  -76.003  1.00 54.62  ? 1366 SER A OG  1 
ATOM   2598 N N   . LEU D 3 23  ? -65.249 49.484  -73.044  1.00 36.73  ? 1367 LEU A N   1 
ATOM   2599 C CA  . LEU D 3 23  ? -65.696 49.456  -71.659  1.00 25.47  ? 1367 LEU A CA  1 
ATOM   2600 C C   . LEU D 3 23  ? -67.006 50.207  -71.478  1.00 32.95  ? 1367 LEU A C   1 
ATOM   2601 O O   . LEU D 3 23  ? -67.739 49.938  -70.519  1.00 38.12  ? 1367 LEU A O   1 
ATOM   2602 C CB  . LEU D 3 23  ? -64.626 50.055  -70.748  1.00 31.10  ? 1367 LEU A CB  1 
ATOM   2603 C CG  . LEU D 3 23  ? -63.415 49.175  -70.453  1.00 24.53  ? 1367 LEU A CG  1 
ATOM   2604 C CD1 . LEU D 3 23  ? -62.543 49.824  -69.395  1.00 23.43  ? 1367 LEU A CD1 1 
ATOM   2605 C CD2 . LEU D 3 23  ? -63.859 47.793  -70.020  1.00 29.09  ? 1367 LEU A CD2 1 
ATOM   2606 N N   . ALA D 3 24  ? -67.316 51.141  -72.378  1.00 32.89  ? 1368 ALA A N   1 
ATOM   2607 C CA  . ALA D 3 24  ? -68.569 51.876  -72.298  1.00 34.70  ? 1368 ALA A CA  1 
ATOM   2608 C C   . ALA D 3 24  ? -69.781 50.999  -72.573  1.00 33.36  ? 1368 ALA A C   1 
ATOM   2609 O O   . ALA D 3 24  ? -70.910 51.482  -72.448  1.00 51.06  ? 1368 ALA A O   1 
ATOM   2610 C CB  . ALA D 3 24  ? -68.550 53.055  -73.271  1.00 50.79  ? 1368 ALA A CB  1 
ATOM   2611 N N   . GLY D 3 25  ? -69.581 49.736  -72.949  1.00 28.93  ? 1369 GLY A N   1 
ATOM   2612 C CA  . GLY D 3 25  ? -70.699 48.824  -73.088  1.00 28.82  ? 1369 GLY A CA  1 
ATOM   2613 C C   . GLY D 3 25  ? -71.397 48.490  -71.787  1.00 29.58  ? 1369 GLY A C   1 
ATOM   2614 O O   . GLY D 3 25  ? -72.496 47.927  -71.822  1.00 32.10  ? 1369 GLY A O   1 
ATOM   2615 N N   . LEU D 3 26  ? -70.790 48.824  -70.648  1.00 30.20  ? 1370 LEU A N   1 
ATOM   2616 C CA  . LEU D 3 26  ? -71.387 48.566  -69.343  1.00 27.41  ? 1370 LEU A CA  1 
ATOM   2617 C C   . LEU D 3 26  ? -72.319 49.685  -68.905  1.00 40.88  ? 1370 LEU A C   1 
ATOM   2618 O O   . LEU D 3 26  ? -73.379 49.415  -68.328  1.00 53.84  ? 1370 LEU A O   1 
ATOM   2619 C CB  . LEU D 3 26  ? -70.296 48.389  -68.287  1.00 28.07  ? 1370 LEU A CB  1 
ATOM   2620 C CG  . LEU D 3 26  ? -69.273 47.281  -68.493  1.00 32.07  ? 1370 LEU A CG  1 
ATOM   2621 C CD1 . LEU D 3 26  ? -67.940 47.765  -67.982  1.00 24.92  ? 1370 LEU A CD1 1 
ATOM   2622 C CD2 . LEU D 3 26  ? -69.707 46.026  -67.753  1.00 38.13  ? 1370 LEU A CD2 1 
ATOM   2623 N N   . ALA D 3 27  ? -71.927 50.933  -69.160  1.00 39.08  ? 1371 ALA A N   1 
ATOM   2624 C CA  . ALA D 3 27  ? -72.694 52.086  -68.695  1.00 47.55  ? 1371 ALA A CA  1 
ATOM   2625 C C   . ALA D 3 27  ? -74.186 52.022  -69.017  1.00 43.46  ? 1371 ALA A C   1 
ATOM   2626 O O   . ALA D 3 27  ? -74.987 52.419  -68.153  1.00 45.47  ? 1371 ALA A O   1 
ATOM   2627 C CB  . ALA D 3 27  ? -72.066 53.370  -69.260  1.00 43.79  ? 1371 ALA A CB  1 
ATOM   2628 N N   . PRO D 3 28  ? -74.631 51.554  -70.190  1.00 22.81  ? 1372 PRO A N   1 
ATOM   2629 C CA  . PRO D 3 28  ? -76.083 51.449  -70.414  1.00 31.44  ? 1372 PRO A CA  1 
ATOM   2630 C C   . PRO D 3 28  ? -76.788 50.487  -69.471  1.00 45.70  ? 1372 PRO A C   1 
ATOM   2631 O O   . PRO D 3 28  ? -77.986 50.660  -69.215  1.00 70.16  ? 1372 PRO A O   1 
ATOM   2632 C CB  . PRO D 3 28  ? -76.175 50.973  -71.870  1.00 25.44  ? 1372 PRO A CB  1 
ATOM   2633 C CG  . PRO D 3 28  ? -74.914 51.440  -72.492  1.00 38.38  ? 1372 PRO A CG  1 
ATOM   2634 C CD  . PRO D 3 28  ? -73.877 51.310  -71.433  1.00 36.70  ? 1372 PRO A CD  1 
ATOM   2635 N N   . HIS D 3 29  ? -76.088 49.481  -68.945  1.00 41.13  ? 1373 HIS A N   1 
ATOM   2636 C CA  . HIS D 3 29  ? -76.712 48.471  -68.099  1.00 39.91  ? 1373 HIS A CA  1 
ATOM   2637 C C   . HIS D 3 29  ? -76.523 48.717  -66.607  1.00 40.70  ? 1373 HIS A C   1 
ATOM   2638 O O   . HIS D 3 29  ? -77.096 47.974  -65.802  1.00 48.39  ? 1373 HIS A O   1 
ATOM   2639 C CB  . HIS D 3 29  ? -76.167 47.078  -68.434  1.00 42.22  ? 1373 HIS A CB  1 
ATOM   2640 C CG  . HIS D 3 29  ? -76.201 46.741  -69.891  1.00 25.81  ? 1373 HIS A CG  1 
ATOM   2641 N ND1 . HIS D 3 29  ? -77.243 46.050  -70.471  1.00 26.17  ? 1373 HIS A ND1 1 
ATOM   2642 C CD2 . HIS D 3 29  ? -75.314 46.987  -70.884  1.00 26.31  ? 1373 HIS A CD2 1 
ATOM   2643 C CE1 . HIS D 3 29  ? -76.999 45.890  -71.759  1.00 40.82  ? 1373 HIS A CE1 1 
ATOM   2644 N NE2 . HIS D 3 29  ? -75.835 46.449  -72.036  1.00 36.38  ? 1373 HIS A NE2 1 
ATOM   2645 N N   . ILE D 3 30  ? -75.731 49.722  -66.218  1.00 36.58  ? 1374 ILE A N   1 
ATOM   2646 C CA  . ILE D 3 30  ? -75.463 49.944  -64.802  1.00 32.91  ? 1374 ILE A CA  1 
ATOM   2647 C C   . ILE D 3 30  ? -76.764 50.267  -64.085  1.00 44.14  ? 1374 ILE A C   1 
ATOM   2648 O O   . ILE D 3 30  ? -77.536 51.133  -64.518  1.00 46.51  ? 1374 ILE A O   1 
ATOM   2649 C CB  . ILE D 3 30  ? -74.427 51.061  -64.611  1.00 23.19  ? 1374 ILE A CB  1 
ATOM   2650 C CG1 . ILE D 3 30  ? -73.101 50.687  -65.275  1.00 28.89  ? 1374 ILE A CG1 1 
ATOM   2651 C CG2 . ILE D 3 30  ? -74.201 51.322  -63.132  1.00 18.15  ? 1374 ILE A CG2 1 
ATOM   2652 C CD1 . ILE D 3 30  ? -71.994 51.699  -65.045  1.00 22.34  ? 1374 ILE A CD1 1 
ATOM   2653 N N   . THR D 3 31  ? -77.020 49.555  -62.989  1.00 39.83  ? 1375 THR A N   1 
ATOM   2654 C CA  . THR D 3 31  ? -78.235 49.713  -62.197  1.00 44.85  ? 1375 THR A CA  1 
ATOM   2655 C C   . THR D 3 31  ? -77.877 50.455  -60.913  1.00 40.34  ? 1375 THR A C   1 
ATOM   2656 O O   . THR D 3 31  ? -77.267 49.882  -60.004  1.00 42.70  ? 1375 THR A O   1 
ATOM   2657 C CB  . THR D 3 31  ? -78.873 48.357  -61.896  1.00 44.68  ? 1375 THR A CB  1 
ATOM   2658 O OG1 . THR D 3 31  ? -77.846 47.377  -61.694  1.00 61.14  ? 1375 THR A OG1 1 
ATOM   2659 C CG2 . THR D 3 31  ? -79.767 47.913  -63.052  1.00 38.97  ? 1375 THR A CG2 1 
ATOM   2660 N N   . LEU D 3 32  ? -78.254 51.729  -60.843  1.00 47.78  ? 1376 LEU A N   1 
ATOM   2661 C CA  . LEU D 3 32  ? -77.978 52.578  -59.689  1.00 48.24  ? 1376 LEU A CA  1 
ATOM   2662 C C   . LEU D 3 32  ? -79.262 52.714  -58.874  1.00 47.12  ? 1376 LEU A C   1 
ATOM   2663 O O   . LEU D 3 32  ? -80.228 53.336  -59.329  1.00 42.63  ? 1376 LEU A O   1 
ATOM   2664 C CB  . LEU D 3 32  ? -77.457 53.940  -60.144  1.00 38.66  ? 1376 LEU A CB  1 
ATOM   2665 C CG  . LEU D 3 32  ? -76.848 54.876  -59.102  1.00 43.84  ? 1376 LEU A CG  1 
ATOM   2666 C CD1 . LEU D 3 32  ? -75.669 55.619  -59.709  1.00 30.56  ? 1376 LEU A CD1 1 
ATOM   2667 C CD2 . LEU D 3 32  ? -77.887 55.859  -58.578  1.00 63.46  ? 1376 LEU A CD2 1 
ATOM   2668 N N   . ASN D 3 33  ? -79.272 52.132  -57.677  1.00 36.39  ? 1377 ASN A N   1 
ATOM   2669 C CA  . ASN D 3 33  ? -80.472 52.154  -56.851  1.00 36.65  ? 1377 ASN A CA  1 
ATOM   2670 C C   . ASN D 3 33  ? -80.839 53.594  -56.503  1.00 53.47  ? 1377 ASN A C   1 
ATOM   2671 O O   . ASN D 3 33  ? -80.001 54.331  -55.965  1.00 70.18  ? 1377 ASN A O   1 
ATOM   2672 C CB  . ASN D 3 33  ? -80.267 51.337  -55.576  1.00 40.95  ? 1377 ASN A CB  1 
ATOM   2673 C CG  . ASN D 3 33  ? -81.581 50.931  -54.923  1.00 49.42  ? 1377 ASN A CG  1 
ATOM   2674 O OD1 . ASN D 3 33  ? -82.422 51.778  -54.617  1.00 51.02  ? 1377 ASN A OD1 1 
ATOM   2675 N ND2 . ASN D 3 33  ? -81.760 49.631  -54.706  1.00 50.70  ? 1377 ASN A ND2 1 
ATOM   2676 N N   . PRO D 3 34  ? -82.070 54.032  -56.787  1.00 51.88  ? 1378 PRO A N   1 
ATOM   2677 C CA  . PRO D 3 34  ? -82.425 55.442  -56.556  1.00 41.58  ? 1378 PRO A CA  1 
ATOM   2678 C C   . PRO D 3 34  ? -82.536 55.826  -55.091  1.00 38.99  ? 1378 PRO A C   1 
ATOM   2679 O O   . PRO D 3 34  ? -82.657 57.022  -54.797  1.00 47.42  ? 1378 PRO A O   1 
ATOM   2680 C CB  . PRO D 3 34  ? -83.780 55.578  -57.260  1.00 53.63  ? 1378 PRO A CB  1 
ATOM   2681 C CG  . PRO D 3 34  ? -84.354 54.195  -57.223  1.00 40.93  ? 1378 PRO A CG  1 
ATOM   2682 C CD  . PRO D 3 34  ? -83.183 53.267  -57.376  1.00 40.40  ? 1378 PRO A CD  1 
ATOM   2683 N N   . THR D 3 35  ? -82.494 54.864  -54.167  1.00 42.24  ? 1379 THR A N   1 
ATOM   2684 C CA  . THR D 3 35  ? -82.738 55.122  -52.753  1.00 31.03  ? 1379 THR A CA  1 
ATOM   2685 C C   . THR D 3 35  ? -81.461 55.082  -51.917  1.00 32.95  ? 1379 THR A C   1 
ATOM   2686 O O   . THR D 3 35  ? -81.536 54.962  -50.690  1.00 28.95  ? 1379 THR A O   1 
ATOM   2687 C CB  . THR D 3 35  ? -83.759 54.121  -52.206  1.00 41.07  ? 1379 THR A CB  1 
ATOM   2688 O OG1 . THR D 3 35  ? -83.129 52.849  -51.994  1.00 40.07  ? 1379 THR A OG1 1 
ATOM   2689 C CG2 . THR D 3 35  ? -84.912 53.950  -53.186  1.00 29.12  ? 1379 THR A CG2 1 
ATOM   2690 N N   . ILE D 3 36  ? -80.298 55.183  -52.547  1.00 34.64  ? 1380 ILE A N   1 
ATOM   2691 C CA  . ILE D 3 36  ? -79.048 55.155  -51.777  1.00 35.86  ? 1380 ILE A CA  1 
ATOM   2692 C C   . ILE D 3 36  ? -78.922 56.447  -50.978  1.00 35.34  ? 1380 ILE A C   1 
ATOM   2693 O O   . ILE D 3 36  ? -79.028 57.545  -51.555  1.00 43.93  ? 1380 ILE A O   1 
ATOM   2694 C CB  . ILE D 3 36  ? -77.849 54.962  -52.703  1.00 38.27  ? 1380 ILE A CB  1 
ATOM   2695 C CG1 . ILE D 3 36  ? -77.710 53.491  -53.096  1.00 29.62  ? 1380 ILE A CG1 1 
ATOM   2696 C CG2 . ILE D 3 36  ? -76.577 55.444  -52.024  1.00 49.69  ? 1380 ILE A CG2 1 
ATOM   2697 C CD1 . ILE D 3 36  ? -77.346 53.284  -54.544  1.00 32.10  ? 1380 ILE A CD1 1 
ATOM   2698 N N   . PRO D 3 37  ? -78.695 56.373  -49.665  1.00 35.03  ? 1381 PRO A N   1 
ATOM   2699 C CA  . PRO D 3 37  ? -78.671 57.599  -48.854  1.00 35.97  ? 1381 PRO A CA  1 
ATOM   2700 C C   . PRO D 3 37  ? -77.531 58.538  -49.192  1.00 41.15  ? 1381 PRO A C   1 
ATOM   2701 O O   . PRO D 3 37  ? -77.685 59.755  -49.028  1.00 46.91  ? 1381 PRO A O   1 
ATOM   2702 C CB  . PRO D 3 37  ? -78.551 57.066  -47.419  1.00 36.77  ? 1381 PRO A CB  1 
ATOM   2703 C CG  . PRO D 3 37  ? -79.018 55.650  -47.495  1.00 47.98  ? 1381 PRO A CG  1 
ATOM   2704 C CD  . PRO D 3 37  ? -78.582 55.164  -48.839  1.00 49.98  ? 1381 PRO A CD  1 
ATOM   2705 N N   . LEU D 3 38  ? -76.386 58.020  -49.644  1.00 40.24  ? 1382 LEU A N   1 
ATOM   2706 C CA  . LEU D 3 38  ? -75.300 58.904  -50.059  1.00 37.18  ? 1382 LEU A CA  1 
ATOM   2707 C C   . LEU D 3 38  ? -75.737 59.836  -51.180  1.00 36.85  ? 1382 LEU A C   1 
ATOM   2708 O O   . LEU D 3 38  ? -75.523 61.052  -51.111  1.00 44.90  ? 1382 LEU A O   1 
ATOM   2709 C CB  . LEU D 3 38  ? -74.080 58.096  -50.491  1.00 33.74  ? 1382 LEU A CB  1 
ATOM   2710 C CG  . LEU D 3 38  ? -72.852 59.004  -50.557  1.00 32.79  ? 1382 LEU A CG  1 
ATOM   2711 C CD1 . LEU D 3 38  ? -71.680 58.441  -49.802  1.00 42.47  ? 1382 LEU A CD1 1 
ATOM   2712 C CD2 . LEU D 3 38  ? -72.486 59.213  -52.008  1.00 30.20  ? 1382 LEU A CD2 1 
ATOM   2713 N N   . PHE D 3 39  ? -76.339 59.281  -52.231  1.00 39.86  ? 1383 PHE A N   1 
ATOM   2714 C CA  . PHE D 3 39  ? -76.776 60.110  -53.346  1.00 35.92  ? 1383 PHE A CA  1 
ATOM   2715 C C   . PHE D 3 39  ? -77.960 60.988  -52.976  1.00 46.90  ? 1383 PHE A C   1 
ATOM   2716 O O   . PHE D 3 39  ? -78.217 61.982  -53.663  1.00 51.23  ? 1383 PHE A O   1 
ATOM   2717 C CB  . PHE D 3 39  ? -77.123 59.230  -54.545  1.00 45.25  ? 1383 PHE A CB  1 
ATOM   2718 C CG  . PHE D 3 39  ? -76.023 58.289  -54.934  1.00 44.91  ? 1383 PHE A CG  1 
ATOM   2719 C CD1 . PHE D 3 39  ? -74.697 58.685  -54.865  1.00 36.73  ? 1383 PHE A CD1 1 
ATOM   2720 C CD2 . PHE D 3 39  ? -76.314 57.005  -55.366  1.00 49.65  ? 1383 PHE A CD2 1 
ATOM   2721 C CE1 . PHE D 3 39  ? -73.681 57.820  -55.222  1.00 39.89  ? 1383 PHE A CE1 1 
ATOM   2722 C CE2 . PHE D 3 39  ? -75.302 56.135  -55.724  1.00 41.43  ? 1383 PHE A CE2 1 
ATOM   2723 C CZ  . PHE D 3 39  ? -73.984 56.543  -55.652  1.00 40.48  ? 1383 PHE A CZ  1 
ATOM   2724 N N   . GLN D 3 40  ? -78.682 60.646  -51.907  1.00 52.91  ? 1384 GLN A N   1 
ATOM   2725 C CA  . GLN D 3 40  ? -79.778 61.495  -51.454  1.00 51.28  ? 1384 GLN A CA  1 
ATOM   2726 C C   . GLN D 3 40  ? -79.257 62.828  -50.930  1.00 45.75  ? 1384 GLN A C   1 
ATOM   2727 O O   . GLN D 3 40  ? -79.896 63.869  -51.123  1.00 47.94  ? 1384 GLN A O   1 
ATOM   2728 C CB  . GLN D 3 40  ? -80.593 60.768  -50.384  1.00 36.23  ? 1384 GLN A CB  1 
ATOM   2729 C CG  . GLN D 3 40  ? -82.096 60.804  -50.615  1.00 45.78  ? 1384 GLN A CG  1 
ATOM   2730 C CD  . GLN D 3 40  ? -82.530 59.923  -51.775  1.00 70.36  ? 1384 GLN A CD  1 
ATOM   2731 O OE1 . GLN D 3 40  ? -81.968 58.848  -52.000  1.00 64.79  ? 1384 GLN A OE1 1 
ATOM   2732 N NE2 . GLN D 3 40  ? -83.534 60.378  -52.520  1.00 56.15  ? 1384 GLN A NE2 1 
ATOM   2733 N N   . ALA D 3 41  ? -78.097 62.816  -50.274  1.00 47.20  ? 1385 ALA A N   1 
ATOM   2734 C CA  . ALA D 3 41  ? -77.472 64.034  -49.774  1.00 43.01  ? 1385 ALA A CA  1 
ATOM   2735 C C   . ALA D 3 41  ? -76.436 64.612  -50.726  1.00 54.27  ? 1385 ALA A C   1 
ATOM   2736 O O   . ALA D 3 41  ? -76.237 65.832  -50.740  1.00 51.38  ? 1385 ALA A O   1 
ATOM   2737 C CB  . ALA D 3 41  ? -76.812 63.774  -48.416  1.00 41.49  ? 1385 ALA A CB  1 
ATOM   2738 N N   . HIS D 3 42  ? -75.769 63.773  -51.517  1.00 53.30  ? 1386 HIS A N   1 
ATOM   2739 C CA  . HIS D 3 42  ? -74.769 64.217  -52.488  1.00 41.99  ? 1386 HIS A CA  1 
ATOM   2740 C C   . HIS D 3 42  ? -75.037 63.532  -53.819  1.00 51.41  ? 1386 HIS A C   1 
ATOM   2741 O O   . HIS D 3 42  ? -74.404 62.520  -54.151  1.00 58.31  ? 1386 HIS A O   1 
ATOM   2742 C CB  . HIS D 3 42  ? -73.349 63.932  -52.000  1.00 39.25  ? 1386 HIS A CB  1 
ATOM   2743 C CG  . HIS D 3 42  ? -73.140 64.237  -50.551  1.00 45.50  ? 1386 HIS A CG  1 
ATOM   2744 N ND1 . HIS D 3 42  ? -73.303 63.293  -49.561  1.00 45.92  ? 1386 HIS A ND1 1 
ATOM   2745 C CD2 . HIS D 3 42  ? -72.783 65.383  -49.924  1.00 53.98  ? 1386 HIS A CD2 1 
ATOM   2746 C CE1 . HIS D 3 42  ? -73.054 63.843  -48.386  1.00 49.05  ? 1386 HIS A CE1 1 
ATOM   2747 N NE2 . HIS D 3 42  ? -72.736 65.110  -48.579  1.00 60.13  ? 1386 HIS A NE2 1 
ATOM   2748 N N   . PRO D 3 43  ? -75.975 64.058  -54.612  1.00 51.43  ? 1387 PRO A N   1 
ATOM   2749 C CA  . PRO D 3 43  ? -76.227 63.469  -55.936  1.00 28.07  ? 1387 PRO A CA  1 
ATOM   2750 C C   . PRO D 3 43  ? -75.080 63.651  -56.912  1.00 40.23  ? 1387 PRO A C   1 
ATOM   2751 O O   . PRO D 3 43  ? -75.024 62.923  -57.911  1.00 49.65  ? 1387 PRO A O   1 
ATOM   2752 C CB  . PRO D 3 43  ? -77.487 64.205  -56.417  1.00 49.55  ? 1387 PRO A CB  1 
ATOM   2753 C CG  . PRO D 3 43  ? -78.100 64.784  -55.175  1.00 54.81  ? 1387 PRO A CG  1 
ATOM   2754 C CD  . PRO D 3 43  ? -76.948 65.111  -54.281  1.00 58.64  ? 1387 PRO A CD  1 
ATOM   2755 N N   . GLN D 3 44  ? -74.168 64.597  -56.667  1.00 49.16  ? 1388 GLN A N   1 
ATOM   2756 C CA  . GLN D 3 44  ? -73.026 64.760  -57.561  1.00 46.23  ? 1388 GLN A CA  1 
ATOM   2757 C C   . GLN D 3 44  ? -72.134 63.526  -57.550  1.00 41.86  ? 1388 GLN A C   1 
ATOM   2758 O O   . GLN D 3 44  ? -71.433 63.256  -58.532  1.00 43.39  ? 1388 GLN A O   1 
ATOM   2759 C CB  . GLN D 3 44  ? -72.212 65.998  -57.177  1.00 44.90  ? 1388 GLN A CB  1 
ATOM   2760 C CG  . GLN D 3 44  ? -71.853 66.081  -55.699  1.00 56.90  ? 1388 GLN A CG  1 
ATOM   2761 C CD  . GLN D 3 44  ? -72.877 66.850  -54.888  1.00 69.53  ? 1388 GLN A CD  1 
ATOM   2762 O OE1 . GLN D 3 44  ? -73.948 66.337  -54.572  1.00 61.30  ? 1388 GLN A OE1 1 
ATOM   2763 N NE2 . GLN D 3 44  ? -72.547 68.089  -54.539  1.00 92.72  ? 1388 GLN A NE2 1 
ATOM   2764 N N   . LEU D 3 45  ? -72.149 62.766  -56.458  1.00 33.95  ? 1389 LEU A N   1 
ATOM   2765 C CA  . LEU D 3 45  ? -71.347 61.557  -56.357  1.00 33.17  ? 1389 LEU A CA  1 
ATOM   2766 C C   . LEU D 3 45  ? -71.917 60.392  -57.155  1.00 44.99  ? 1389 LEU A C   1 
ATOM   2767 O O   . LEU D 3 45  ? -71.293 59.326  -57.198  1.00 45.25  ? 1389 LEU A O   1 
ATOM   2768 C CB  . LEU D 3 45  ? -71.191 61.161  -54.890  1.00 29.84  ? 1389 LEU A CB  1 
ATOM   2769 C CG  . LEU D 3 45  ? -70.190 62.057  -54.163  1.00 33.32  ? 1389 LEU A CG  1 
ATOM   2770 C CD1 . LEU D 3 45  ? -70.086 61.670  -52.714  1.00 25.52  ? 1389 LEU A CD1 1 
ATOM   2771 C CD2 . LEU D 3 45  ? -68.833 61.969  -54.839  1.00 50.40  ? 1389 LEU A CD2 1 
ATOM   2772 N N   . LYS D 3 46  ? -73.079 60.564  -57.788  1.00 41.11  ? 1390 LYS A N   1 
ATOM   2773 C CA  . LYS D 3 46  ? -73.590 59.534  -58.683  1.00 34.73  ? 1390 LYS A CA  1 
ATOM   2774 C C   . LYS D 3 46  ? -72.694 59.339  -59.897  1.00 49.18  ? 1390 LYS A C   1 
ATOM   2775 O O   . LYS D 3 46  ? -72.748 58.280  -60.531  1.00 60.10  ? 1390 LYS A O   1 
ATOM   2776 C CB  . LYS D 3 46  ? -75.005 59.890  -59.141  1.00 34.70  ? 1390 LYS A CB  1 
ATOM   2777 C CG  . LYS D 3 46  ? -76.106 59.431  -58.204  1.00 40.49  ? 1390 LYS A CG  1 
ATOM   2778 C CD  . LYS D 3 46  ? -77.314 60.351  -58.299  1.00 47.68  ? 1390 LYS A CD  1 
ATOM   2779 C CE  . LYS D 3 46  ? -78.614 59.581  -58.132  1.00 70.44  ? 1390 LYS A CE  1 
ATOM   2780 N NZ  . LYS D 3 46  ? -79.681 60.079  -59.046  1.00 60.74  ? 1390 LYS A NZ  1 
ATOM   2781 N N   . GLN D 3 47  ? -71.865 60.330  -60.230  1.00 53.39  ? 1391 GLN A N   1 
ATOM   2782 C CA  . GLN D 3 47  ? -71.069 60.288  -61.449  1.00 55.09  ? 1391 GLN A CA  1 
ATOM   2783 C C   . GLN D 3 47  ? -69.771 59.505  -61.297  1.00 58.18  ? 1391 GLN A C   1 
ATOM   2784 O O   . GLN D 3 47  ? -69.120 59.223  -62.309  1.00 69.29  ? 1391 GLN A O   1 
ATOM   2785 C CB  . GLN D 3 47  ? -70.763 61.713  -61.917  1.00 77.28  ? 1391 GLN A CB  1 
ATOM   2786 C CG  . GLN D 3 47  ? -71.887 62.706  -61.642  1.00 87.51  ? 1391 GLN A CG  1 
ATOM   2787 C CD  . GLN D 3 47  ? -72.917 62.754  -62.757  1.00 100.13 ? 1391 GLN A CD  1 
ATOM   2788 O OE1 . GLN D 3 47  ? -73.693 61.816  -62.943  1.00 92.57  ? 1391 GLN A OE1 1 
ATOM   2789 N NE2 . GLN D 3 47  ? -72.934 63.855  -63.500  1.00 96.56  ? 1391 GLN A NE2 1 
ATOM   2790 N N   . CYS D 3 48  ? -69.377 59.148  -60.075  1.00 48.47  ? 1392 CYS A N   1 
ATOM   2791 C CA  . CYS D 3 48  ? -68.183 58.335  -59.883  1.00 53.56  ? 1392 CYS A CA  1 
ATOM   2792 C C   . CYS D 3 48  ? -68.429 56.853  -60.131  1.00 46.60  ? 1392 CYS A C   1 
ATOM   2793 O O   . CYS D 3 48  ? -67.473 56.072  -60.103  1.00 50.11  ? 1392 CYS A O   1 
ATOM   2794 C CB  . CYS D 3 48  ? -67.632 58.520  -58.466  1.00 47.48  ? 1392 CYS A CB  1 
ATOM   2795 S SG  . CYS D 3 48  ? -67.586 60.231  -57.893  1.00 84.83  ? 1392 CYS A SG  1 
ATOM   2796 N N   . VAL D 3 49  ? -69.674 56.452  -60.389  1.00 37.98  ? 1393 VAL A N   1 
ATOM   2797 C CA  . VAL D 3 49  ? -70.011 55.032  -60.431  1.00 29.85  ? 1393 VAL A CA  1 
ATOM   2798 C C   . VAL D 3 49  ? -69.576 54.399  -61.751  1.00 36.45  ? 1393 VAL A C   1 
ATOM   2799 O O   . VAL D 3 49  ? -68.888 53.372  -61.758  1.00 33.56  ? 1393 VAL A O   1 
ATOM   2800 C CB  . VAL D 3 49  ? -71.516 54.837  -60.173  1.00 20.40  ? 1393 VAL A CB  1 
ATOM   2801 C CG1 . VAL D 3 49  ? -71.864 53.360  -60.193  1.00 29.32  ? 1393 VAL A CG1 1 
ATOM   2802 C CG2 . VAL D 3 49  ? -71.906 55.456  -58.842  1.00 19.21  ? 1393 VAL A CG2 1 
ATOM   2803 N N   . ARG D 3 50  ? -69.982 54.987  -62.883  1.00 38.97  ? 1394 ARG A N   1 
ATOM   2804 C CA  . ARG D 3 50  ? -69.599 54.457  -64.192  1.00 37.04  ? 1394 ARG A CA  1 
ATOM   2805 C C   . ARG D 3 50  ? -68.088 54.270  -64.282  1.00 36.48  ? 1394 ARG A C   1 
ATOM   2806 O O   . ARG D 3 50  ? -67.601 53.219  -64.716  1.00 41.45  ? 1394 ARG A O   1 
ATOM   2807 C CB  . ARG D 3 50  ? -70.102 55.400  -65.294  1.00 56.09  ? 1394 ARG A CB  1 
ATOM   2808 C CG  . ARG D 3 50  ? -69.113 55.682  -66.438  1.00 67.06  ? 1394 ARG A CG  1 
ATOM   2809 C CD  . ARG D 3 50  ? -69.793 56.293  -67.672  1.00 71.34  ? 1394 ARG A CD  1 
ATOM   2810 N NE  . ARG D 3 50  ? -68.837 56.746  -68.684  1.00 97.87  ? 1394 ARG A NE  1 
ATOM   2811 C CZ  . ARG D 3 50  ? -67.995 55.957  -69.342  1.00 93.94  ? 1394 ARG A CZ  1 
ATOM   2812 N NH1 . ARG D 3 50  ? -68.086 54.639  -69.276  1.00 86.77  ? 1394 ARG A NH1 1 
ATOM   2813 N NH2 . ARG D 3 50  ? -67.069 56.503  -70.126  1.00 82.83  ? 1394 ARG A NH2 1 
ATOM   2814 N N   . GLN D 3 51  ? -67.330 55.277  -63.844  1.00 44.42  ? 1395 GLN A N   1 
ATOM   2815 C CA  . GLN D 3 51  ? -65.875 55.179  -63.844  1.00 45.55  ? 1395 GLN A CA  1 
ATOM   2816 C C   . GLN D 3 51  ? -65.410 54.043  -62.938  1.00 43.41  ? 1395 GLN A C   1 
ATOM   2817 O O   . GLN D 3 51  ? -64.704 53.129  -63.382  1.00 42.99  ? 1395 GLN A O   1 
ATOM   2818 C CB  . GLN D 3 51  ? -65.276 56.533  -63.424  1.00 54.47  ? 1395 GLN A CB  1 
ATOM   2819 C CG  . GLN D 3 51  ? -63.992 56.559  -62.560  1.00 73.10  ? 1395 GLN A CG  1 
ATOM   2820 C CD  . GLN D 3 51  ? -62.883 55.593  -62.975  1.00 81.61  ? 1395 GLN A CD  1 
ATOM   2821 O OE1 . GLN D 3 51  ? -62.811 55.139  -64.121  1.00 77.93  ? 1395 GLN A OE1 1 
ATOM   2822 N NE2 . GLN D 3 51  ? -62.025 55.257  -62.021  1.00 75.80  ? 1395 GLN A NE2 1 
ATOM   2823 N N   . ALA D 3 52  ? -65.815 54.074  -61.664  1.00 44.02  ? 1396 ALA A N   1 
ATOM   2824 C CA  . ALA D 3 52  ? -65.300 53.107  -60.699  1.00 40.91  ? 1396 ALA A CA  1 
ATOM   2825 C C   . ALA D 3 52  ? -65.622 51.676  -61.113  1.00 39.65  ? 1396 ALA A C   1 
ATOM   2826 O O   . ALA D 3 52  ? -64.813 50.764  -60.904  1.00 43.09  ? 1396 ALA A O   1 
ATOM   2827 C CB  . ALA D 3 52  ? -65.858 53.400  -59.307  1.00 45.72  ? 1396 ALA A CB  1 
ATOM   2828 N N   . ILE D 3 53  ? -66.794 51.460  -61.713  1.00 31.74  ? 1397 ILE A N   1 
ATOM   2829 C CA  . ILE D 3 53  ? -67.166 50.115  -62.136  1.00 27.21  ? 1397 ILE A CA  1 
ATOM   2830 C C   . ILE D 3 53  ? -66.278 49.656  -63.286  1.00 28.14  ? 1397 ILE A C   1 
ATOM   2831 O O   . ILE D 3 53  ? -65.767 48.531  -63.286  1.00 39.76  ? 1397 ILE A O   1 
ATOM   2832 C CB  . ILE D 3 53  ? -68.660 50.065  -62.507  1.00 31.49  ? 1397 ILE A CB  1 
ATOM   2833 C CG1 . ILE D 3 53  ? -69.500 49.816  -61.251  1.00 21.49  ? 1397 ILE A CG1 1 
ATOM   2834 C CG2 . ILE D 3 53  ? -68.930 48.991  -63.558  1.00 14.83  ? 1397 ILE A CG2 1 
ATOM   2835 C CD1 . ILE D 3 53  ? -70.988 49.741  -61.509  1.00 28.98  ? 1397 ILE A CD1 1 
ATOM   2836 N N   . GLU D 3 54  ? -66.062 50.528  -64.271  1.00 30.65  ? 1398 GLU A N   1 
ATOM   2837 C CA  . GLU D 3 54  ? -65.245 50.155  -65.419  1.00 23.74  ? 1398 GLU A CA  1 
ATOM   2838 C C   . GLU D 3 54  ? -63.764 50.077  -65.084  1.00 32.75  ? 1398 GLU A C   1 
ATOM   2839 O O   . GLU D 3 54  ? -63.022 49.377  -65.781  1.00 47.67  ? 1398 GLU A O   1 
ATOM   2840 C CB  . GLU D 3 54  ? -65.465 51.132  -66.563  1.00 21.99  ? 1398 GLU A CB  1 
ATOM   2841 C CG  . GLU D 3 54  ? -66.907 51.231  -66.997  1.00 51.62  ? 1398 GLU A CG  1 
ATOM   2842 C CD  . GLU D 3 54  ? -67.105 52.301  -68.035  1.00 65.90  ? 1398 GLU A CD  1 
ATOM   2843 O OE1 . GLU D 3 54  ? -68.232 52.431  -68.566  1.00 68.09  ? 1398 GLU A OE1 1 
ATOM   2844 O OE2 . GLU D 3 54  ? -66.131 53.033  -68.321  1.00 58.80  ? 1398 GLU A OE2 1 
ATOM   2845 N N   . ARG D 3 55  ? -63.311 50.789  -64.054  1.00 32.66  ? 1399 ARG A N   1 
ATOM   2846 C CA  . ARG D 3 55  ? -61.944 50.593  -63.589  1.00 36.05  ? 1399 ARG A CA  1 
ATOM   2847 C C   . ARG D 3 55  ? -61.757 49.172  -63.072  1.00 44.29  ? 1399 ARG A C   1 
ATOM   2848 O O   . ARG D 3 55  ? -60.786 48.491  -63.423  1.00 49.42  ? 1399 ARG A O   1 
ATOM   2849 C CB  . ARG D 3 55  ? -61.608 51.615  -62.505  1.00 50.10  ? 1399 ARG A CB  1 
ATOM   2850 C CG  . ARG D 3 55  ? -60.134 51.946  -62.410  1.00 54.45  ? 1399 ARG A CG  1 
ATOM   2851 C CD  . ARG D 3 55  ? -59.880 52.969  -61.323  1.00 77.51  ? 1399 ARG A CD  1 
ATOM   2852 N NE  . ARG D 3 55  ? -58.456 53.209  -61.134  1.00 99.32  ? 1399 ARG A NE  1 
ATOM   2853 C CZ  . ARG D 3 55  ? -57.645 52.395  -60.474  1.00 94.06  ? 1399 ARG A CZ  1 
ATOM   2854 N NH1 . ARG D 3 55  ? -58.086 51.277  -59.922  1.00 75.57  ? 1399 ARG A NH1 1 
ATOM   2855 N NH2 . ARG D 3 55  ? -56.357 52.710  -60.367  1.00 99.15  ? 1399 ARG A NH2 1 
ATOM   2856 N N   . ALA D 3 56  ? -62.698 48.703  -62.248  1.00 44.76  ? 1400 ALA A N   1 
ATOM   2857 C CA  . ALA D 3 56  ? -62.613 47.349  -61.712  1.00 27.44  ? 1400 ALA A CA  1 
ATOM   2858 C C   . ALA D 3 56  ? -62.690 46.308  -62.821  1.00 34.36  ? 1400 ALA A C   1 
ATOM   2859 O O   . ALA D 3 56  ? -61.976 45.302  -62.784  1.00 41.46  ? 1400 ALA A O   1 
ATOM   2860 C CB  . ALA D 3 56  ? -63.725 47.123  -60.688  1.00 33.14  ? 1400 ALA A CB  1 
ATOM   2861 N N   . VAL D 3 57  ? -63.543 46.536  -63.824  1.00 37.97  ? 1401 VAL A N   1 
ATOM   2862 C CA  . VAL D 3 57  ? -63.725 45.534  -64.868  1.00 31.99  ? 1401 VAL A CA  1 
ATOM   2863 C C   . VAL D 3 57  ? -62.524 45.470  -65.805  1.00 40.73  ? 1401 VAL A C   1 
ATOM   2864 O O   . VAL D 3 57  ? -62.316 44.446  -66.465  1.00 40.82  ? 1401 VAL A O   1 
ATOM   2865 C CB  . VAL D 3 57  ? -65.016 45.804  -65.667  1.00 27.72  ? 1401 VAL A CB  1 
ATOM   2866 C CG1 . VAL D 3 57  ? -64.769 46.845  -66.733  1.00 46.08  ? 1401 VAL A CG1 1 
ATOM   2867 C CG2 . VAL D 3 57  ? -65.549 44.520  -66.293  1.00 24.06  ? 1401 VAL A CG2 1 
ATOM   2868 N N   . GLN D 3 58  ? -61.720 46.531  -65.883  1.00 43.77  ? 1402 GLN A N   1 
ATOM   2869 C CA  . GLN D 3 58  ? -60.573 46.527  -66.782  1.00 39.33  ? 1402 GLN A CA  1 
ATOM   2870 C C   . GLN D 3 58  ? -59.319 45.982  -66.119  1.00 33.70  ? 1402 GLN A C   1 
ATOM   2871 O O   . GLN D 3 58  ? -58.474 45.391  -66.801  1.00 47.21  ? 1402 GLN A O   1 
ATOM   2872 C CB  . GLN D 3 58  ? -60.306 47.939  -67.319  1.00 42.24  ? 1402 GLN A CB  1 
ATOM   2873 C CG  . GLN D 3 58  ? -59.149 48.672  -66.653  1.00 60.65  ? 1402 GLN A CG  1 
ATOM   2874 C CD  . GLN D 3 58  ? -59.099 50.148  -67.007  1.00 71.75  ? 1402 GLN A CD  1 
ATOM   2875 O OE1 . GLN D 3 58  ? -59.990 50.669  -67.678  1.00 55.84  ? 1402 GLN A OE1 1 
ATOM   2876 N NE2 . GLN D 3 58  ? -58.058 50.832  -66.543  1.00 82.01  ? 1402 GLN A NE2 1 
ATOM   2877 N N   . GLU D 3 59  ? -59.186 46.151  -64.804  1.00 23.40  ? 1403 GLU A N   1 
ATOM   2878 C CA  . GLU D 3 59  ? -58.022 45.634  -64.102  1.00 36.92  ? 1403 GLU A CA  1 
ATOM   2879 C C   . GLU D 3 59  ? -58.055 44.121  -63.957  1.00 38.92  ? 1403 GLU A C   1 
ATOM   2880 O O   . GLU D 3 59  ? -57.020 43.526  -63.639  1.00 48.73  ? 1403 GLU A O   1 
ATOM   2881 C CB  . GLU D 3 59  ? -57.913 46.283  -62.724  1.00 42.08  ? 1403 GLU A CB  1 
ATOM   2882 C CG  . GLU D 3 59  ? -57.417 47.719  -62.760  1.00 48.07  ? 1403 GLU A CG  1 
ATOM   2883 C CD  . GLU D 3 59  ? -56.450 48.030  -61.637  1.00 84.41  ? 1403 GLU A CD  1 
ATOM   2884 O OE1 . GLU D 3 59  ? -56.395 47.251  -60.661  1.00 94.57  ? 1403 GLU A OE1 1 
ATOM   2885 O OE2 . GLU D 3 59  ? -55.745 49.056  -61.731  1.00 102.85 ? 1403 GLU A OE2 1 
ATOM   2886 N N   . LEU D 3 60  ? -59.205 43.491  -64.193  1.00 31.50  ? 1404 LEU A N   1 
ATOM   2887 C CA  . LEU D 3 60  ? -59.356 42.056  -64.019  1.00 33.90  ? 1404 LEU A CA  1 
ATOM   2888 C C   . LEU D 3 60  ? -59.727 41.307  -65.288  1.00 40.37  ? 1404 LEU A C   1 
ATOM   2889 O O   . LEU D 3 60  ? -59.649 40.073  -65.294  1.00 49.33  ? 1404 LEU A O   1 
ATOM   2890 C CB  . LEU D 3 60  ? -60.412 41.748  -62.945  1.00 23.98  ? 1404 LEU A CB  1 
ATOM   2891 C CG  . LEU D 3 60  ? -60.023 42.009  -61.488  1.00 35.70  ? 1404 LEU A CG  1 
ATOM   2892 C CD1 . LEU D 3 60  ? -60.635 43.282  -60.922  1.00 37.07  ? 1404 LEU A CD1 1 
ATOM   2893 C CD2 . LEU D 3 60  ? -60.434 40.818  -60.663  1.00 38.69  ? 1404 LEU A CD2 1 
ATOM   2894 N N   . VAL D 3 61  ? -60.127 42.000  -66.354  1.00 37.72  ? 1405 VAL A N   1 
ATOM   2895 C CA  . VAL D 3 61  ? -60.604 41.300  -67.542  1.00 36.95  ? 1405 VAL A CA  1 
ATOM   2896 C C   . VAL D 3 61  ? -59.472 40.520  -68.201  1.00 47.43  ? 1405 VAL A C   1 
ATOM   2897 O O   . VAL D 3 61  ? -59.653 39.370  -68.616  1.00 46.89  ? 1405 VAL A O   1 
ATOM   2898 C CB  . VAL D 3 61  ? -61.260 42.291  -68.521  1.00 32.07  ? 1405 VAL A CB  1 
ATOM   2899 C CG1 . VAL D 3 61  ? -60.308 43.438  -68.863  1.00 32.37  ? 1405 VAL A CG1 1 
ATOM   2900 C CG2 . VAL D 3 61  ? -61.727 41.567  -69.772  1.00 31.93  ? 1405 VAL A CG2 1 
ATOM   2901 N N   . HIS D 3 62  ? -58.282 41.122  -68.289  1.00 50.55  ? 1406 HIS A N   1 
ATOM   2902 C CA  . HIS D 3 62  ? -57.186 40.458  -68.993  1.00 41.24  ? 1406 HIS A CA  1 
ATOM   2903 C C   . HIS D 3 62  ? -56.610 39.292  -68.200  1.00 35.07  ? 1406 HIS A C   1 
ATOM   2904 O O   . HIS D 3 62  ? -56.410 38.215  -68.789  1.00 44.23  ? 1406 HIS A O   1 
ATOM   2905 C CB  . HIS D 3 62  ? -56.116 41.485  -69.372  1.00 53.01  ? 1406 HIS A CB  1 
ATOM   2906 C CG  . HIS D 3 62  ? -56.506 42.353  -70.526  1.00 49.73  ? 1406 HIS A CG  1 
ATOM   2907 N ND1 . HIS D 3 62  ? -57.110 41.853  -71.659  1.00 51.08  ? 1406 HIS A ND1 1 
ATOM   2908 C CD2 . HIS D 3 62  ? -56.379 43.687  -70.725  1.00 53.48  ? 1406 HIS A CD2 1 
ATOM   2909 C CE1 . HIS D 3 62  ? -57.340 42.840  -72.506  1.00 58.36  ? 1406 HIS A CE1 1 
ATOM   2910 N NE2 . HIS D 3 62  ? -56.905 43.963  -71.964  1.00 65.59  ? 1406 HIS A NE2 1 
ATOM   2911 N N   . PRO D 3 63  ? -56.318 39.415  -66.898  1.00 34.40  ? 1407 PRO A N   1 
ATOM   2912 C CA  . PRO D 3 63  ? -55.848 38.227  -66.163  1.00 44.26  ? 1407 PRO A CA  1 
ATOM   2913 C C   . PRO D 3 63  ? -56.868 37.101  -66.114  1.00 47.96  ? 1407 PRO A C   1 
ATOM   2914 O O   . PRO D 3 63  ? -56.487 35.925  -66.192  1.00 49.46  ? 1407 PRO A O   1 
ATOM   2915 C CB  . PRO D 3 63  ? -55.544 38.779  -64.761  1.00 30.77  ? 1407 PRO A CB  1 
ATOM   2916 C CG  . PRO D 3 63  ? -55.289 40.228  -64.976  1.00 46.90  ? 1407 PRO A CG  1 
ATOM   2917 C CD  . PRO D 3 63  ? -56.230 40.632  -66.071  1.00 49.01  ? 1407 PRO A CD  1 
ATOM   2918 N N   . VAL D 3 64  ? -58.158 37.426  -65.989  1.00 39.05  ? 1408 VAL A N   1 
ATOM   2919 C CA  . VAL D 3 64  ? -59.177 36.385  -65.886  1.00 26.76  ? 1408 VAL A CA  1 
ATOM   2920 C C   . VAL D 3 64  ? -59.355 35.672  -67.221  1.00 37.06  ? 1408 VAL A C   1 
ATOM   2921 O O   . VAL D 3 64  ? -59.478 34.442  -67.270  1.00 42.49  ? 1408 VAL A O   1 
ATOM   2922 C CB  . VAL D 3 64  ? -60.503 36.983  -65.375  1.00 22.97  ? 1408 VAL A CB  1 
ATOM   2923 C CG1 . VAL D 3 64  ? -61.674 36.045  -65.664  1.00 27.93  ? 1408 VAL A CG1 1 
ATOM   2924 C CG2 . VAL D 3 64  ? -60.412 37.277  -63.883  1.00 21.74  ? 1408 VAL A CG2 1 
ATOM   2925 N N   . VAL D 3 65  ? -59.357 36.424  -68.324  1.00 38.32  ? 1409 VAL A N   1 
ATOM   2926 C CA  . VAL D 3 65  ? -59.576 35.818  -69.636  1.00 37.02  ? 1409 VAL A CA  1 
ATOM   2927 C C   . VAL D 3 65  ? -58.499 34.779  -69.923  1.00 36.67  ? 1409 VAL A C   1 
ATOM   2928 O O   . VAL D 3 65  ? -58.790 33.655  -70.350  1.00 40.36  ? 1409 VAL A O   1 
ATOM   2929 C CB  . VAL D 3 65  ? -59.625 36.901  -70.730  1.00 36.29  ? 1409 VAL A CB  1 
ATOM   2930 C CG1 . VAL D 3 65  ? -59.189 36.334  -72.075  1.00 35.89  ? 1409 VAL A CG1 1 
ATOM   2931 C CG2 . VAL D 3 65  ? -61.017 37.503  -70.822  1.00 39.53  ? 1409 VAL A CG2 1 
ATOM   2932 N N   . ASP D 3 66  ? -57.238 35.133  -69.667  1.00 42.97  ? 1410 ASP A N   1 
ATOM   2933 C CA  . ASP D 3 66  ? -56.141 34.216  -69.955  1.00 47.21  ? 1410 ASP A CA  1 
ATOM   2934 C C   . ASP D 3 66  ? -56.217 32.975  -69.074  1.00 32.51  ? 1410 ASP A C   1 
ATOM   2935 O O   . ASP D 3 66  ? -56.071 31.847  -69.559  1.00 43.75  ? 1410 ASP A O   1 
ATOM   2936 C CB  . ASP D 3 66  ? -54.802 34.935  -69.780  1.00 54.79  ? 1410 ASP A CB  1 
ATOM   2937 C CG  . ASP D 3 66  ? -54.520 35.925  -70.900  1.00 62.71  ? 1410 ASP A CG  1 
ATOM   2938 O OD1 . ASP D 3 66  ? -55.254 35.912  -71.913  1.00 73.96  ? 1410 ASP A OD1 1 
ATOM   2939 O OD2 . ASP D 3 66  ? -53.564 36.719  -70.766  1.00 62.54  ? 1410 ASP A OD2 1 
ATOM   2940 N N   . ARG D 3 67  ? -56.456 33.159  -67.775  1.00 25.45  ? 1411 ARG A N   1 
ATOM   2941 C CA  . ARG D 3 67  ? -56.595 32.005  -66.894  1.00 37.72  ? 1411 ARG A CA  1 
ATOM   2942 C C   . ARG D 3 67  ? -57.788 31.146  -67.292  1.00 37.55  ? 1411 ARG A C   1 
ATOM   2943 O O   . ARG D 3 67  ? -57.716 29.913  -67.251  1.00 43.30  ? 1411 ARG A O   1 
ATOM   2944 C CB  . ARG D 3 67  ? -56.728 32.456  -65.442  1.00 36.12  ? 1411 ARG A CB  1 
ATOM   2945 C CG  . ARG D 3 67  ? -57.079 31.324  -64.500  1.00 41.93  ? 1411 ARG A CG  1 
ATOM   2946 C CD  . ARG D 3 67  ? -56.935 31.739  -63.045  1.00 54.17  ? 1411 ARG A CD  1 
ATOM   2947 N NE  . ARG D 3 67  ? -56.818 30.613  -62.121  1.00 71.34  ? 1411 ARG A NE  1 
ATOM   2948 C CZ  . ARG D 3 67  ? -55.955 29.606  -62.225  1.00 82.26  ? 1411 ARG A CZ  1 
ATOM   2949 N NH1 . ARG D 3 67  ? -55.031 29.569  -63.176  1.00 60.21  ? 1411 ARG A NH1 1 
ATOM   2950 N NH2 . ARG D 3 67  ? -56.006 28.618  -61.337  1.00 99.27  ? 1411 ARG A NH2 1 
ATOM   2951 N N   . SER D 3 68  ? -58.891 31.780  -67.695  1.00 33.98  ? 1412 SER A N   1 
ATOM   2952 C CA  . SER D 3 68  ? -60.107 31.031  -67.989  1.00 25.32  ? 1412 SER A CA  1 
ATOM   2953 C C   . SER D 3 68  ? -59.911 30.114  -69.188  1.00 29.08  ? 1412 SER A C   1 
ATOM   2954 O O   . SER D 3 68  ? -60.280 28.934  -69.146  1.00 30.82  ? 1412 SER A O   1 
ATOM   2955 C CB  . SER D 3 68  ? -61.266 31.996  -68.228  1.00 37.63  ? 1412 SER A CB  1 
ATOM   2956 O OG  . SER D 3 68  ? -61.795 32.441  -66.993  1.00 30.54  ? 1412 SER A OG  1 
ATOM   2957 N N   . ILE D 3 69  ? -59.328 30.643  -70.271  1.00 32.98  ? 1413 ILE A N   1 
ATOM   2958 C CA  . ILE D 3 69  ? -59.058 29.812  -71.440  1.00 32.90  ? 1413 ILE A CA  1 
ATOM   2959 C C   . ILE D 3 69  ? -58.043 28.733  -71.100  1.00 37.83  ? 1413 ILE A C   1 
ATOM   2960 O O   . ILE D 3 69  ? -58.131 27.614  -71.612  1.00 50.90  ? 1413 ILE A O   1 
ATOM   2961 C CB  . ILE D 3 69  ? -58.634 30.681  -72.654  1.00 30.02  ? 1413 ILE A CB  1 
ATOM   2962 C CG1 . ILE D 3 69  ? -57.214 31.286  -72.545  1.00 40.32  ? 1413 ILE A CG1 1 
ATOM   2963 C CG2 . ILE D 3 69  ? -59.669 31.767  -72.925  1.00 22.62  ? 1413 ILE A CG2 1 
ATOM   2964 C CD1 . ILE D 3 69  ? -56.039 30.370  -72.938  1.00 41.69  ? 1413 ILE A CD1 1 
ATOM   2965 N N   . LYS D 3 70  ? -57.094 29.030  -70.209  1.00 29.00  ? 1414 LYS A N   1 
ATOM   2966 C CA  . LYS D 3 70  ? -56.081 28.043  -69.852  1.00 30.99  ? 1414 LYS A CA  1 
ATOM   2967 C C   . LYS D 3 70  ? -56.719 26.797  -69.251  1.00 42.63  ? 1414 LYS A C   1 
ATOM   2968 O O   . LYS D 3 70  ? -56.445 25.671  -69.686  1.00 50.70  ? 1414 LYS A O   1 
ATOM   2969 C CB  . LYS D 3 70  ? -55.072 28.661  -68.882  1.00 28.97  ? 1414 LYS A CB  1 
ATOM   2970 C CG  . LYS D 3 70  ? -54.095 27.669  -68.269  1.00 28.99  ? 1414 LYS A CG  1 
ATOM   2971 C CD  . LYS D 3 70  ? -52.910 28.386  -67.631  1.00 37.18  ? 1414 LYS A CD  1 
ATOM   2972 C CE  . LYS D 3 70  ? -51.956 27.413  -66.950  1.00 56.50  ? 1414 LYS A CE  1 
ATOM   2973 N NZ  . LYS D 3 70  ? -52.672 26.283  -66.294  1.00 74.99  ? 1414 LYS A NZ  1 
ATOM   2974 N N   . ILE D 3 71  ? -57.594 26.985  -68.261  1.00 33.86  ? 1415 ILE A N   1 
ATOM   2975 C CA  . ILE D 3 71  ? -58.243 25.854  -67.606  1.00 23.78  ? 1415 ILE A CA  1 
ATOM   2976 C C   . ILE D 3 71  ? -59.197 25.137  -68.551  1.00 37.99  ? 1415 ILE A C   1 
ATOM   2977 O O   . ILE D 3 71  ? -59.352 23.912  -68.474  1.00 54.12  ? 1415 ILE A O   1 
ATOM   2978 C CB  . ILE D 3 71  ? -58.960 26.338  -66.333  1.00 24.86  ? 1415 ILE A CB  1 
ATOM   2979 C CG1 . ILE D 3 71  ? -58.075 27.341  -65.591  1.00 34.72  ? 1415 ILE A CG1 1 
ATOM   2980 C CG2 . ILE D 3 71  ? -59.337 25.162  -65.451  1.00 34.78  ? 1415 ILE A CG2 1 
ATOM   2981 C CD1 . ILE D 3 71  ? -58.681 27.903  -64.334  1.00 43.67  ? 1415 ILE A CD1 1 
ATOM   2982 N N   . ALA D 3 72  ? -59.842 25.871  -69.455  1.00 31.13  ? 1416 ALA A N   1 
ATOM   2983 C CA  . ALA D 3 72  ? -60.829 25.278  -70.350  1.00 32.38  ? 1416 ALA A CA  1 
ATOM   2984 C C   . ALA D 3 72  ? -60.215 24.652  -71.594  1.00 44.58  ? 1416 ALA A C   1 
ATOM   2985 O O   . ALA D 3 72  ? -60.764 23.679  -72.121  1.00 44.44  ? 1416 ALA A O   1 
ATOM   2986 C CB  . ALA D 3 72  ? -61.856 26.330  -70.772  1.00 35.78  ? 1416 ALA A CB  1 
ATOM   2987 N N   . MET D 3 73  ? -59.085 25.180  -72.065  1.00 48.58  ? 1417 MET A N   1 
ATOM   2988 C CA  . MET D 3 73  ? -58.549 24.772  -73.359  1.00 31.94  ? 1417 MET A CA  1 
ATOM   2989 C C   . MET D 3 73  ? -58.206 23.290  -73.394  1.00 30.42  ? 1417 MET A C   1 
ATOM   2990 O O   . MET D 3 73  ? -58.736 22.538  -74.221  1.00 26.20  ? 1417 MET A O   1 
ATOM   2991 C CB  . MET D 3 73  ? -57.326 25.615  -73.705  1.00 46.43  ? 1417 MET A CB  1 
ATOM   2992 C CG  . MET D 3 73  ? -56.815 25.357  -75.083  1.00 43.00  ? 1417 MET A CG  1 
ATOM   2993 S SD  . MET D 3 73  ? -58.209 25.479  -76.192  1.00 64.73  ? 1417 MET A SD  1 
ATOM   2994 C CE  . MET D 3 73  ? -57.964 27.119  -76.804  1.00 63.70  ? 1417 MET A CE  1 
ATOM   2995 N N   . THR D 3 74  ? -57.298 22.856  -72.515  1.00 27.23  ? 1418 THR A N   1 
ATOM   2996 C CA  . THR D 3 74  ? -56.807 21.484  -72.574  1.00 21.29  ? 1418 THR A CA  1 
ATOM   2997 C C   . THR D 3 74  ? -57.949 20.488  -72.444  1.00 28.50  ? 1418 THR A C   1 
ATOM   2998 O O   . THR D 3 74  ? -58.024 19.514  -73.200  1.00 32.67  ? 1418 THR A O   1 
ATOM   2999 C CB  . THR D 3 74  ? -55.770 21.250  -71.481  1.00 24.51  ? 1418 THR A CB  1 
ATOM   3000 O OG1 . THR D 3 74  ? -54.621 22.070  -71.730  1.00 51.80  ? 1418 THR A OG1 1 
ATOM   3001 C CG2 . THR D 3 74  ? -55.349 19.791  -71.472  1.00 36.61  ? 1418 THR A CG2 1 
ATOM   3002 N N   . THR D 3 75  ? -58.857 20.723  -71.496  1.00 32.99  ? 1419 THR A N   1 
ATOM   3003 C CA  . THR D 3 75  ? -60.022 19.855  -71.359  1.00 29.37  ? 1419 THR A CA  1 
ATOM   3004 C C   . THR D 3 75  ? -60.844 19.831  -72.642  1.00 35.24  ? 1419 THR A C   1 
ATOM   3005 O O   . THR D 3 75  ? -61.236 18.761  -73.123  1.00 33.81  ? 1419 THR A O   1 
ATOM   3006 C CB  . THR D 3 75  ? -60.887 20.308  -70.184  1.00 32.34  ? 1419 THR A CB  1 
ATOM   3007 O OG1 . THR D 3 75  ? -60.079 20.431  -69.005  1.00 36.52  ? 1419 THR A OG1 1 
ATOM   3008 C CG2 . THR D 3 75  ? -62.001 19.300  -69.933  1.00 26.91  ? 1419 THR A CG2 1 
ATOM   3009 N N   . CYS D 3 76  ? -61.099 21.006  -73.224  1.00 36.29  ? 1420 CYS A N   1 
ATOM   3010 C CA  . CYS D 3 76  ? -61.997 21.072  -74.373  1.00 39.23  ? 1420 CYS A CA  1 
ATOM   3011 C C   . CYS D 3 76  ? -61.420 20.392  -75.606  1.00 45.34  ? 1420 CYS A C   1 
ATOM   3012 O O   . CYS D 3 76  ? -62.179 19.836  -76.408  1.00 36.67  ? 1420 CYS A O   1 
ATOM   3013 C CB  . CYS D 3 76  ? -62.362 22.518  -74.701  1.00 45.62  ? 1420 CYS A CB  1 
ATOM   3014 S SG  . CYS D 3 76  ? -63.598 23.231  -73.598  1.00 66.75  ? 1420 CYS A SG  1 
ATOM   3015 N N   . GLU D 3 77  ? -60.100 20.426  -75.791  1.00 45.89  ? 1421 GLU A N   1 
ATOM   3016 C CA  . GLU D 3 77  ? -59.532 19.790  -76.975  1.00 42.93  ? 1421 GLU A CA  1 
ATOM   3017 C C   . GLU D 3 77  ? -59.551 18.268  -76.858  1.00 39.77  ? 1421 GLU A C   1 
ATOM   3018 O O   . GLU D 3 77  ? -59.773 17.568  -77.853  1.00 40.09  ? 1421 GLU A O   1 
ATOM   3019 C CB  . GLU D 3 77  ? -58.112 20.294  -77.230  1.00 36.68  ? 1421 GLU A CB  1 
ATOM   3020 C CG  . GLU D 3 77  ? -57.041 19.529  -76.467  1.00 50.92  ? 1421 GLU A CG  1 
ATOM   3021 C CD  . GLU D 3 77  ? -55.642 19.851  -76.927  1.00 60.97  ? 1421 GLU A CD  1 
ATOM   3022 O OE1 . GLU D 3 77  ? -55.447 19.975  -78.154  1.00 48.85  ? 1421 GLU A OE1 1 
ATOM   3023 O OE2 . GLU D 3 77  ? -54.744 19.982  -76.066  1.00 62.08  ? 1421 GLU A OE2 1 
ATOM   3024 N N   . GLN D 3 78  ? -59.338 17.732  -75.654  1.00 35.67  ? 1422 GLN A N   1 
ATOM   3025 C CA  . GLN D 3 78  ? -59.185 16.288  -75.521  1.00 32.20  ? 1422 GLN A CA  1 
ATOM   3026 C C   . GLN D 3 78  ? -60.521 15.567  -75.587  1.00 32.25  ? 1422 GLN A C   1 
ATOM   3027 O O   . GLN D 3 78  ? -60.597 14.468  -76.149  1.00 31.99  ? 1422 GLN A O   1 
ATOM   3028 C CB  . GLN D 3 78  ? -58.455 15.956  -74.221  1.00 31.78  ? 1422 GLN A CB  1 
ATOM   3029 C CG  . GLN D 3 78  ? -57.168 16.746  -74.032  1.00 40.21  ? 1422 GLN A CG  1 
ATOM   3030 C CD  . GLN D 3 78  ? -55.943 15.869  -73.906  1.00 39.20  ? 1422 GLN A CD  1 
ATOM   3031 O OE1 . GLN D 3 78  ? -55.811 15.102  -72.952  1.00 49.45  ? 1422 GLN A OE1 1 
ATOM   3032 N NE2 . GLN D 3 78  ? -55.029 15.985  -74.865  1.00 35.41  ? 1422 GLN A NE2 1 
ATOM   3033 N N   . ILE D 3 79  ? -61.580 16.170  -75.044  1.00 23.48  ? 1423 ILE A N   1 
ATOM   3034 C CA  . ILE D 3 79  ? -62.891 15.532  -75.088  1.00 23.69  ? 1423 ILE A CA  1 
ATOM   3035 C C   . ILE D 3 79  ? -63.473 15.587  -76.497  1.00 28.32  ? 1423 ILE A C   1 
ATOM   3036 O O   . ILE D 3 79  ? -64.114 14.632  -76.955  1.00 29.48  ? 1423 ILE A O   1 
ATOM   3037 C CB  . ILE D 3 79  ? -63.833 16.178  -74.058  1.00 16.33  ? 1423 ILE A CB  1 
ATOM   3038 C CG1 . ILE D 3 79  ? -63.226 16.083  -72.659  1.00 14.12  ? 1423 ILE A CG1 1 
ATOM   3039 C CG2 . ILE D 3 79  ? -65.198 15.507  -74.085  1.00 21.20  ? 1423 ILE A CG2 1 
ATOM   3040 C CD1 . ILE D 3 79  ? -62.849 14.678  -72.256  1.00 15.31  ? 1423 ILE A CD1 1 
ATOM   3041 N N   . VAL D 3 80  ? -63.261 16.694  -77.212  1.00 22.52  ? 1424 VAL A N   1 
ATOM   3042 C CA  . VAL D 3 80  ? -63.819 16.803  -78.557  1.00 28.41  ? 1424 VAL A CA  1 
ATOM   3043 C C   . VAL D 3 80  ? -63.061 15.907  -79.528  1.00 37.69  ? 1424 VAL A C   1 
ATOM   3044 O O   . VAL D 3 80  ? -63.668 15.235  -80.372  1.00 45.44  ? 1424 VAL A O   1 
ATOM   3045 C CB  . VAL D 3 80  ? -63.833 18.267  -79.028  1.00 24.88  ? 1424 VAL A CB  1 
ATOM   3046 C CG1 . VAL D 3 80  ? -64.290 18.347  -80.475  1.00 33.51  ? 1424 VAL A CG1 1 
ATOM   3047 C CG2 . VAL D 3 80  ? -64.755 19.088  -78.157  1.00 36.06  ? 1424 VAL A CG2 1 
ATOM   3048 N N   . ARG D 3 81  ? -61.727 15.878  -79.430  1.00 25.02  ? 1425 ARG A N   1 
ATOM   3049 C CA  . ARG D 3 81  ? -60.954 14.977  -80.281  1.00 26.08  ? 1425 ARG A CA  1 
ATOM   3050 C C   . ARG D 3 81  ? -61.337 13.524  -80.027  1.00 31.89  ? 1425 ARG A C   1 
ATOM   3051 O O   . ARG D 3 81  ? -61.524 12.747  -80.971  1.00 38.96  ? 1425 ARG A O   1 
ATOM   3052 C CB  . ARG D 3 81  ? -59.454 15.182  -80.056  1.00 28.45  ? 1425 ARG A CB  1 
ATOM   3053 C CG  . ARG D 3 81  ? -58.604 14.018  -80.558  1.00 45.85  ? 1425 ARG A CG  1 
ATOM   3054 C CD  . ARG D 3 81  ? -57.111 14.248  -80.365  1.00 49.29  ? 1425 ARG A CD  1 
ATOM   3055 N NE  . ARG D 3 81  ? -56.670 15.548  -80.855  1.00 77.24  ? 1425 ARG A NE  1 
ATOM   3056 C CZ  . ARG D 3 81  ? -55.782 16.318  -80.240  1.00 81.08  ? 1425 ARG A CZ  1 
ATOM   3057 N NH1 . ARG D 3 81  ? -55.215 15.947  -79.103  1.00 75.12  ? 1425 ARG A NH1 1 
ATOM   3058 N NH2 . ARG D 3 81  ? -55.450 17.487  -80.781  1.00 66.93  ? 1425 ARG A NH2 1 
ATOM   3059 N N   . LYS D 3 82  ? -61.470 13.147  -78.755  1.00 23.96  ? 1426 LYS A N   1 
ATOM   3060 C CA  . LYS D 3 82  ? -61.858 11.782  -78.417  1.00 27.86  ? 1426 LYS A CA  1 
ATOM   3061 C C   . LYS D 3 82  ? -63.235 11.440  -78.971  1.00 35.05  ? 1426 LYS A C   1 
ATOM   3062 O O   . LYS D 3 82  ? -63.448 10.338  -79.491  1.00 43.05  ? 1426 LYS A O   1 
ATOM   3063 C CB  . LYS D 3 82  ? -61.833 11.601  -76.900  1.00 31.44  ? 1426 LYS A CB  1 
ATOM   3064 C CG  . LYS D 3 82  ? -62.467 10.314  -76.405  1.00 37.34  ? 1426 LYS A CG  1 
ATOM   3065 C CD  . LYS D 3 82  ? -62.850 10.434  -74.935  1.00 15.91  ? 1426 LYS A CD  1 
ATOM   3066 C CE  . LYS D 3 82  ? -64.258 10.977  -74.780  1.00 24.96  ? 1426 LYS A CE  1 
ATOM   3067 N NZ  . LYS D 3 82  ? -65.230 10.225  -75.627  1.00 34.85  ? 1426 LYS A NZ  1 
ATOM   3068 N N   . ASP D 3 83  ? -64.180 12.375  -78.879  1.00 28.75  ? 1427 ASP A N   1 
ATOM   3069 C CA  . ASP D 3 83  ? -65.558 12.074  -79.240  1.00 20.97  ? 1427 ASP A CA  1 
ATOM   3070 C C   . ASP D 3 83  ? -65.773 12.043  -80.748  1.00 25.47  ? 1427 ASP A C   1 
ATOM   3071 O O   . ASP D 3 83  ? -66.646 11.312  -81.228  1.00 37.74  ? 1427 ASP A O   1 
ATOM   3072 C CB  . ASP D 3 83  ? -66.496 13.089  -78.591  1.00 21.46  ? 1427 ASP A CB  1 
ATOM   3073 C CG  . ASP D 3 83  ? -67.012 12.621  -77.248  1.00 27.01  ? 1427 ASP A CG  1 
ATOM   3074 O OD1 . ASP D 3 83  ? -67.099 11.392  -77.046  1.00 33.70  ? 1427 ASP A OD1 1 
ATOM   3075 O OD2 . ASP D 3 83  ? -67.319 13.477  -76.389  1.00 42.09  ? 1427 ASP A OD2 1 
ATOM   3076 N N   . PHE D 3 84  ? -64.998 12.812  -81.511  1.00 21.00  ? 1428 PHE A N   1 
ATOM   3077 C CA  . PHE D 3 84  ? -65.170 12.880  -82.956  1.00 24.32  ? 1428 PHE A CA  1 
ATOM   3078 C C   . PHE D 3 84  ? -64.071 12.141  -83.711  1.00 31.15  ? 1428 PHE A C   1 
ATOM   3079 O O   . PHE D 3 84  ? -63.896 12.359  -84.914  1.00 36.42  ? 1428 PHE A O   1 
ATOM   3080 C CB  . PHE D 3 84  ? -65.238 14.338  -83.411  1.00 22.87  ? 1428 PHE A CB  1 
ATOM   3081 C CG  . PHE D 3 84  ? -66.501 15.036  -83.007  1.00 21.64  ? 1428 PHE A CG  1 
ATOM   3082 C CD1 . PHE D 3 84  ? -66.622 15.606  -81.751  1.00 23.46  ? 1428 PHE A CD1 1 
ATOM   3083 C CD2 . PHE D 3 84  ? -67.571 15.117  -83.882  1.00 28.43  ? 1428 PHE A CD2 1 
ATOM   3084 C CE1 . PHE D 3 84  ? -67.787 16.246  -81.375  1.00 22.41  ? 1428 PHE A CE1 1 
ATOM   3085 C CE2 . PHE D 3 84  ? -68.738 15.756  -83.513  1.00 34.88  ? 1428 PHE A CE2 1 
ATOM   3086 C CZ  . PHE D 3 84  ? -68.845 16.320  -82.257  1.00 24.40  ? 1428 PHE A CZ  1 
ATOM   3087 N N   . ALA D 3 85  ? -63.334 11.258  -83.032  1.00 27.95  ? 1429 ALA A N   1 
ATOM   3088 C CA  . ALA D 3 85  ? -62.197 10.600  -83.665  1.00 31.12  ? 1429 ALA A CA  1 
ATOM   3089 C C   . ALA D 3 85  ? -62.615 9.677   -84.801  1.00 35.48  ? 1429 ALA A C   1 
ATOM   3090 O O   . ALA D 3 85  ? -61.760 9.257   -85.589  1.00 39.92  ? 1429 ALA A O   1 
ATOM   3091 C CB  . ALA D 3 85  ? -61.395 9.815   -82.624  1.00 38.57  ? 1429 ALA A CB  1 
ATOM   3092 N N   . LEU D 3 86  ? -63.902 9.348   -84.906  1.00 37.11  ? 1430 LEU A N   1 
ATOM   3093 C CA  . LEU D 3 86  ? -64.409 8.515   -85.989  1.00 33.96  ? 1430 LEU A CA  1 
ATOM   3094 C C   . LEU D 3 86  ? -65.351 9.279   -86.912  1.00 48.12  ? 1430 LEU A C   1 
ATOM   3095 O O   . LEU D 3 86  ? -66.181 8.668   -87.590  1.00 50.59  ? 1430 LEU A O   1 
ATOM   3096 C CB  . LEU D 3 86  ? -65.100 7.274   -85.423  1.00 35.33  ? 1430 LEU A CB  1 
ATOM   3097 C CG  . LEU D 3 86  ? -64.185 6.230   -84.783  1.00 24.01  ? 1430 LEU A CG  1 
ATOM   3098 C CD1 . LEU D 3 86  ? -64.871 4.876   -84.737  1.00 38.43  ? 1430 LEU A CD1 1 
ATOM   3099 C CD2 . LEU D 3 86  ? -62.869 6.138   -85.538  1.00 30.87  ? 1430 LEU A CD2 1 
ATOM   3100 N N   . ASP D 3 87  ? -65.234 10.603  -86.955  1.00 46.86  ? 1431 ASP A N   1 
ATOM   3101 C CA  . ASP D 3 87  ? -66.013 11.436  -87.860  1.00 44.57  ? 1431 ASP A CA  1 
ATOM   3102 C C   . ASP D 3 87  ? -65.063 12.127  -88.826  1.00 47.85  ? 1431 ASP A C   1 
ATOM   3103 O O   . ASP D 3 87  ? -64.039 12.675  -88.409  1.00 48.55  ? 1431 ASP A O   1 
ATOM   3104 C CB  . ASP D 3 87  ? -66.838 12.466  -87.093  1.00 35.25  ? 1431 ASP A CB  1 
ATOM   3105 C CG  . ASP D 3 87  ? -67.900 13.127  -87.948  1.00 55.63  ? 1431 ASP A CG  1 
ATOM   3106 O OD1 . ASP D 3 87  ? -68.884 13.627  -87.368  1.00 76.01  ? 1431 ASP A OD1 1 
ATOM   3107 O OD2 . ASP D 3 87  ? -67.765 13.146  -89.193  1.00 73.12  ? 1431 ASP A OD2 1 
ATOM   3108 N N   . SER D 3 88  ? -65.409 12.107  -90.112  1.00 56.34  ? 1432 SER A N   1 
ATOM   3109 C CA  . SER D 3 88  ? -64.586 12.709  -91.152  1.00 60.52  ? 1432 SER A CA  1 
ATOM   3110 C C   . SER D 3 88  ? -65.028 14.120  -91.520  1.00 58.98  ? 1432 SER A C   1 
ATOM   3111 O O   . SER D 3 88  ? -64.393 14.751  -92.371  1.00 59.59  ? 1432 SER A O   1 
ATOM   3112 C CB  . SER D 3 88  ? -64.586 11.819  -92.401  1.00 63.21  ? 1432 SER A CB  1 
ATOM   3113 O OG  . SER D 3 88  ? -65.803 11.934  -93.121  1.00 70.99  ? 1432 SER A OG  1 
ATOM   3114 N N   . GLU D 3 89  ? -66.091 14.629  -90.901  1.00 56.47  ? 1433 GLU A N   1 
ATOM   3115 C CA  . GLU D 3 89  ? -66.617 15.961  -91.193  1.00 51.21  ? 1433 GLU A CA  1 
ATOM   3116 C C   . GLU D 3 89  ? -66.095 16.926  -90.133  1.00 52.50  ? 1433 GLU A C   1 
ATOM   3117 O O   . GLU D 3 89  ? -66.648 17.017  -89.033  1.00 38.56  ? 1433 GLU A O   1 
ATOM   3118 C CB  . GLU D 3 89  ? -68.142 15.944  -91.227  1.00 50.33  ? 1433 GLU A CB  1 
ATOM   3119 C CG  . GLU D 3 89  ? -68.726 15.128  -92.366  1.00 69.73  ? 1433 GLU A CG  1 
ATOM   3120 C CD  . GLU D 3 89  ? -68.387 15.695  -93.732  1.00 91.61  ? 1433 GLU A CD  1 
ATOM   3121 O OE1 . GLU D 3 89  ? -68.115 16.912  -93.826  1.00 93.21  ? 1433 GLU A OE1 1 
ATOM   3122 O OE2 . GLU D 3 89  ? -68.391 14.922  -94.713  1.00 86.93  ? 1433 GLU A OE2 1 
ATOM   3123 N N   . GLU D 3 90  ? -65.027 17.654  -90.472  1.00 58.82  ? 1434 GLU A N   1 
ATOM   3124 C CA  . GLU D 3 90  ? -64.490 18.653  -89.555  1.00 44.62  ? 1434 GLU A CA  1 
ATOM   3125 C C   . GLU D 3 90  ? -65.495 19.757  -89.262  1.00 36.20  ? 1434 GLU A C   1 
ATOM   3126 O O   . GLU D 3 90  ? -65.345 20.468  -88.263  1.00 35.83  ? 1434 GLU A O   1 
ATOM   3127 C CB  . GLU D 3 90  ? -63.203 19.254  -90.124  1.00 39.89  ? 1434 GLU A CB  1 
ATOM   3128 C CG  . GLU D 3 90  ? -63.419 20.190  -91.303  1.00 52.72  ? 1434 GLU A CG  1 
ATOM   3129 C CD  . GLU D 3 90  ? -63.187 19.508  -92.637  1.00 66.28  ? 1434 GLU A CD  1 
ATOM   3130 O OE1 . GLU D 3 90  ? -63.066 18.265  -92.654  1.00 74.63  ? 1434 GLU A OE1 1 
ATOM   3131 O OE2 . GLU D 3 90  ? -63.121 20.211  -93.669  1.00 65.08  ? 1434 GLU A OE2 1 
ATOM   3132 N N   . SER D 3 91  ? -66.517 19.908  -90.107  1.00 41.02  ? 1435 SER A N   1 
ATOM   3133 C CA  . SER D 3 91  ? -67.535 20.928  -89.879  1.00 36.51  ? 1435 SER A CA  1 
ATOM   3134 C C   . SER D 3 91  ? -68.298 20.669  -88.585  1.00 37.41  ? 1435 SER A C   1 
ATOM   3135 O O   . SER D 3 91  ? -68.516 21.586  -87.785  1.00 39.31  ? 1435 SER A O   1 
ATOM   3136 C CB  . SER D 3 91  ? -68.493 20.978  -91.070  1.00 43.88  ? 1435 SER A CB  1 
ATOM   3137 O OG  . SER D 3 91  ? -68.992 22.289  -91.268  1.00 58.97  ? 1435 SER A OG  1 
ATOM   3138 N N   . ARG D 3 92  ? -68.713 19.419  -88.360  1.00 44.75  ? 1436 ARG A N   1 
ATOM   3139 C CA  . ARG D 3 92  ? -69.484 19.107  -87.159  1.00 44.03  ? 1436 ARG A CA  1 
ATOM   3140 C C   . ARG D 3 92  ? -68.616 19.169  -85.910  1.00 33.05  ? 1436 ARG A C   1 
ATOM   3141 O O   . ARG D 3 92  ? -69.080 19.592  -84.844  1.00 37.10  ? 1436 ARG A O   1 
ATOM   3142 C CB  . ARG D 3 92  ? -70.140 17.730  -87.290  1.00 59.53  ? 1436 ARG A CB  1 
ATOM   3143 C CG  . ARG D 3 92  ? -71.273 17.670  -88.307  1.00 85.36  ? 1436 ARG A CG  1 
ATOM   3144 C CD  . ARG D 3 92  ? -72.098 16.392  -88.168  1.00 58.43  ? 1436 ARG A CD  1 
ATOM   3145 N NE  . ARG D 3 92  ? -71.308 15.199  -88.448  1.00 61.79  ? 1436 ARG A NE  1 
ATOM   3146 C CZ  . ARG D 3 92  ? -71.114 14.696  -89.660  1.00 84.03  ? 1436 ARG A CZ  1 
ATOM   3147 N NH1 . ARG D 3 92  ? -71.628 15.269  -90.737  1.00 90.74  ? 1436 ARG A NH1 1 
ATOM   3148 N NH2 . ARG D 3 92  ? -70.381 13.596  -89.797  1.00 83.06  ? 1436 ARG A NH2 1 
ATOM   3149 N N   . MET D 3 93  ? -67.353 18.754  -86.019  1.00 23.27  ? 1437 MET A N   1 
ATOM   3150 C CA  . MET D 3 93  ? -66.469 18.789  -84.858  1.00 25.82  ? 1437 MET A CA  1 
ATOM   3151 C C   . MET D 3 93  ? -66.121 20.223  -84.478  1.00 30.45  ? 1437 MET A C   1 
ATOM   3152 O O   . MET D 3 93  ? -66.101 20.572  -83.290  1.00 22.26  ? 1437 MET A O   1 
ATOM   3153 C CB  . MET D 3 93  ? -65.206 17.983  -85.145  1.00 32.09  ? 1437 MET A CB  1 
ATOM   3154 C CG  . MET D 3 93  ? -63.976 18.481  -84.425  1.00 35.85  ? 1437 MET A CG  1 
ATOM   3155 S SD  . MET D 3 93  ? -62.570 17.391  -84.683  1.00 40.06  ? 1437 MET A SD  1 
ATOM   3156 C CE  . MET D 3 93  ? -61.271 18.382  -83.952  1.00 48.35  ? 1437 MET A CE  1 
ATOM   3157 N N   . ARG D 3 94  ? -65.847 21.065  -85.476  1.00 33.08  ? 1438 ARG A N   1 
ATOM   3158 C CA  . ARG D 3 94  ? -65.577 22.475  -85.217  1.00 29.91  ? 1438 ARG A CA  1 
ATOM   3159 C C   . ARG D 3 94  ? -66.759 23.135  -84.520  1.00 29.43  ? 1438 ARG A C   1 
ATOM   3160 O O   . ARG D 3 94  ? -66.587 23.872  -83.541  1.00 40.14  ? 1438 ARG A O   1 
ATOM   3161 C CB  . ARG D 3 94  ? -65.263 23.184  -86.532  1.00 29.78  ? 1438 ARG A CB  1 
ATOM   3162 C CG  . ARG D 3 94  ? -64.831 24.631  -86.403  1.00 37.69  ? 1438 ARG A CG  1 
ATOM   3163 C CD  . ARG D 3 94  ? -64.657 25.232  -87.795  1.00 41.96  ? 1438 ARG A CD  1 
ATOM   3164 N NE  . ARG D 3 94  ? -63.501 26.110  -87.941  1.00 54.25  ? 1438 ARG A NE  1 
ATOM   3165 C CZ  . ARG D 3 94  ? -63.330 27.264  -87.307  1.00 67.55  ? 1438 ARG A CZ  1 
ATOM   3166 N NH1 . ARG D 3 94  ? -64.214 27.715  -86.430  1.00 62.46  ? 1438 ARG A NH1 1 
ATOM   3167 N NH2 . ARG D 3 94  ? -62.251 27.995  -87.574  1.00 70.10  ? 1438 ARG A NH2 1 
ATOM   3168 N N   . ILE D 3 95  ? -67.974 22.871  -85.009  1.00 23.53  ? 1439 ILE A N   1 
ATOM   3169 C CA  . ILE D 3 95  ? -69.172 23.456  -84.412  1.00 21.78  ? 1439 ILE A CA  1 
ATOM   3170 C C   . ILE D 3 95  ? -69.326 22.996  -82.969  1.00 39.55  ? 1439 ILE A C   1 
ATOM   3171 O O   . ILE D 3 95  ? -69.571 23.801  -82.061  1.00 48.12  ? 1439 ILE A O   1 
ATOM   3172 C CB  . ILE D 3 95  ? -70.414 23.100  -85.249  1.00 30.95  ? 1439 ILE A CB  1 
ATOM   3173 C CG1 . ILE D 3 95  ? -70.567 24.077  -86.412  1.00 25.90  ? 1439 ILE A CG1 1 
ATOM   3174 C CG2 . ILE D 3 95  ? -71.665 23.105  -84.382  1.00 47.74  ? 1439 ILE A CG2 1 
ATOM   3175 C CD1 . ILE D 3 95  ? -71.000 25.460  -85.981  1.00 53.16  ? 1439 ILE A CD1 1 
ATOM   3176 N N   . ALA D 3 96  ? -69.187 21.690  -82.736  1.00 35.99  ? 1440 ALA A N   1 
ATOM   3177 C CA  . ALA D 3 96  ? -69.381 21.160  -81.393  1.00 24.40  ? 1440 ALA A CA  1 
ATOM   3178 C C   . ALA D 3 96  ? -68.281 21.627  -80.449  1.00 20.25  ? 1440 ALA A C   1 
ATOM   3179 O O   . ALA D 3 96  ? -68.550 21.934  -79.281  1.00 31.69  ? 1440 ALA A O   1 
ATOM   3180 C CB  . ALA D 3 96  ? -69.443 19.635  -81.437  1.00 32.14  ? 1440 ALA A CB  1 
ATOM   3181 N N   . ALA D 3 97  ? -67.039 21.695  -80.938  1.00 17.53  ? 1441 ALA A N   1 
ATOM   3182 C CA  . ALA D 3 97  ? -65.933 22.124  -80.089  1.00 25.78  ? 1441 ALA A CA  1 
ATOM   3183 C C   . ALA D 3 97  ? -66.112 23.566  -79.630  1.00 30.51  ? 1441 ALA A C   1 
ATOM   3184 O O   . ALA D 3 97  ? -65.863 23.891  -78.462  1.00 29.26  ? 1441 ALA A O   1 
ATOM   3185 C CB  . ALA D 3 97  ? -64.609 21.962  -80.830  1.00 23.50  ? 1441 ALA A CB  1 
ATOM   3186 N N   . HIS D 3 98  ? -66.542 24.446  -80.536  1.00 21.94  ? 1442 HIS A N   1 
ATOM   3187 C CA  . HIS D 3 98  ? -66.770 25.835  -80.157  1.00 21.52  ? 1442 HIS A CA  1 
ATOM   3188 C C   . HIS D 3 98  ? -67.928 25.955  -79.177  1.00 31.61  ? 1442 HIS A C   1 
ATOM   3189 O O   . HIS D 3 98  ? -67.867 26.749  -78.232  1.00 33.34  ? 1442 HIS A O   1 
ATOM   3190 C CB  . HIS D 3 98  ? -67.019 26.683  -81.402  1.00 36.32  ? 1442 HIS A CB  1 
ATOM   3191 C CG  . HIS D 3 98  ? -65.770 27.254  -81.995  1.00 63.43  ? 1442 HIS A CG  1 
ATOM   3192 N ND1 . HIS D 3 98  ? -64.626 26.507  -82.175  1.00 63.78  ? 1442 HIS A ND1 1 
ATOM   3193 C CD2 . HIS D 3 98  ? -65.483 28.497  -82.449  1.00 64.48  ? 1442 HIS A CD2 1 
ATOM   3194 C CE1 . HIS D 3 98  ? -63.687 27.265  -82.712  1.00 47.65  ? 1442 HIS A CE1 1 
ATOM   3195 N NE2 . HIS D 3 98  ? -64.182 28.477  -82.890  1.00 60.15  ? 1442 HIS A NE2 1 
ATOM   3196 N N   . HIS D 3 99  ? -68.988 25.169  -79.381  1.00 33.08  ? 1443 HIS A N   1 
ATOM   3197 C CA  . HIS D 3 99  ? -70.111 25.182  -78.449  1.00 28.57  ? 1443 HIS A CA  1 
ATOM   3198 C C   . HIS D 3 99  ? -69.656 24.870  -77.032  1.00 27.56  ? 1443 HIS A C   1 
ATOM   3199 O O   . HIS D 3 99  ? -70.074 25.535  -76.076  1.00 32.29  ? 1443 HIS A O   1 
ATOM   3200 C CB  . HIS D 3 99  ? -71.169 24.174  -78.890  1.00 34.73  ? 1443 HIS A CB  1 
ATOM   3201 C CG  . HIS D 3 99  ? -71.984 24.627  -80.057  1.00 41.05  ? 1443 HIS A CG  1 
ATOM   3202 N ND1 . HIS D 3 99  ? -72.967 23.846  -80.625  1.00 43.71  ? 1443 HIS A ND1 1 
ATOM   3203 C CD2 . HIS D 3 99  ? -71.967 25.783  -80.760  1.00 54.31  ? 1443 HIS A CD2 1 
ATOM   3204 C CE1 . HIS D 3 99  ? -73.519 24.500  -81.631  1.00 64.43  ? 1443 HIS A CE1 1 
ATOM   3205 N NE2 . HIS D 3 99  ? -72.930 25.679  -81.734  1.00 81.28  ? 1443 HIS A NE2 1 
ATOM   3206 N N   . MET D 3 100 ? -68.792 23.866  -76.878  1.00 28.31  ? 1444 MET A N   1 
ATOM   3207 C CA  . MET D 3 100 ? -68.397 23.419  -75.551  1.00 35.89  ? 1444 MET A CA  1 
ATOM   3208 C C   . MET D 3 100 ? -67.334 24.313  -74.925  1.00 31.90  ? 1444 MET A C   1 
ATOM   3209 O O   . MET D 3 100 ? -67.233 24.362  -73.694  1.00 44.39  ? 1444 MET A O   1 
ATOM   3210 C CB  . MET D 3 100 ? -67.913 21.966  -75.609  1.00 38.03  ? 1444 MET A CB  1 
ATOM   3211 C CG  . MET D 3 100 ? -67.829 21.285  -74.246  1.00 58.48  ? 1444 MET A CG  1 
ATOM   3212 S SD  . MET D 3 100 ? -66.787 19.812  -74.190  1.00 38.87  ? 1444 MET A SD  1 
ATOM   3213 C CE  . MET D 3 100 ? -65.295 20.460  -74.915  1.00 30.70  ? 1444 MET A CE  1 
ATOM   3214 N N   . MET D 3 101 ? -66.550 25.030  -75.732  1.00 30.97  ? 1445 MET A N   1 
ATOM   3215 C CA  . MET D 3 101 ? -65.612 25.990  -75.158  1.00 36.18  ? 1445 MET A CA  1 
ATOM   3216 C C   . MET D 3 101 ? -66.335 27.198  -74.583  1.00 35.63  ? 1445 MET A C   1 
ATOM   3217 O O   . MET D 3 101 ? -66.019 27.650  -73.476  1.00 31.03  ? 1445 MET A O   1 
ATOM   3218 C CB  . MET D 3 101 ? -64.591 26.437  -76.199  1.00 40.32  ? 1445 MET A CB  1 
ATOM   3219 C CG  . MET D 3 101 ? -63.502 27.304  -75.594  1.00 38.51  ? 1445 MET A CG  1 
ATOM   3220 S SD  . MET D 3 101 ? -62.227 26.354  -74.743  1.00 49.82  ? 1445 MET A SD  1 
ATOM   3221 C CE  . MET D 3 101 ? -60.849 27.491  -74.801  1.00 35.08  ? 1445 MET A CE  1 
ATOM   3222 N N   A ARG D 3 102 ? -67.301 27.744  -75.328  0.58 36.41  ? 1446 ARG A N   1 
ATOM   3223 N N   B ARG D 3 102 ? -67.297 27.745  -75.331  0.42 36.29  ? 1446 ARG A N   1 
ATOM   3224 C CA  A ARG D 3 102 ? -68.042 28.907  -74.847  0.58 34.44  ? 1446 ARG A CA  1 
ATOM   3225 C CA  B ARG D 3 102 ? -68.050 28.900  -74.854  0.42 34.52  ? 1446 ARG A CA  1 
ATOM   3226 C C   A ARG D 3 102 ? -68.695 28.624  -73.501  0.58 35.65  ? 1446 ARG A C   1 
ATOM   3227 C C   B ARG D 3 102 ? -68.685 28.620  -73.500  0.42 35.69  ? 1446 ARG A C   1 
ATOM   3228 O O   A ARG D 3 102 ? -68.746 29.500  -72.630  0.58 40.91  ? 1446 ARG A O   1 
ATOM   3229 O O   B ARG D 3 102 ? -68.714 29.490  -72.622  0.42 40.87  ? 1446 ARG A O   1 
ATOM   3230 C CB  A ARG D 3 102 ? -69.093 29.322  -75.878  0.58 36.39  ? 1446 ARG A CB  1 
ATOM   3231 C CB  B ARG D 3 102 ? -69.123 29.284  -75.875  0.42 36.28  ? 1446 ARG A CB  1 
ATOM   3232 C CG  A ARG D 3 102 ? -68.532 29.603  -77.265  0.58 32.97  ? 1446 ARG A CG  1 
ATOM   3233 C CG  B ARG D 3 102 ? -68.582 29.727  -77.227  0.42 32.94  ? 1446 ARG A CG  1 
ATOM   3234 C CD  A ARG D 3 102 ? -69.387 30.607  -78.027  0.58 32.04  ? 1446 ARG A CD  1 
ATOM   3235 C CD  B ARG D 3 102 ? -69.706 29.873  -78.239  0.42 33.20  ? 1446 ARG A CD  1 
ATOM   3236 N NE  A ARG D 3 102 ? -69.044 30.673  -79.443  0.58 32.74  ? 1446 ARG A NE  1 
ATOM   3237 N NE  B ARG D 3 102 ? -70.093 31.266  -78.434  0.42 30.47  ? 1446 ARG A NE  1 
ATOM   3238 C CZ  A ARG D 3 102 ? -67.908 31.161  -79.925  0.58 32.45  ? 1446 ARG A CZ  1 
ATOM   3239 C CZ  B ARG D 3 102 ? -71.151 31.833  -77.871  0.42 28.84  ? 1446 ARG A CZ  1 
ATOM   3240 N NH1 A ARG D 3 102 ? -66.965 31.642  -79.130  0.58 23.79  ? 1446 ARG A NH1 1 
ATOM   3241 N NH1 B ARG D 3 102 ? -71.950 31.156  -77.061  0.42 16.59  ? 1446 ARG A NH1 1 
ATOM   3242 N NH2 A ARG D 3 102 ? -67.714 31.169  -81.241  0.58 28.59  ? 1446 ARG A NH2 1 
ATOM   3243 N NH2 B ARG D 3 102 ? -71.414 33.112  -78.126  0.42 31.36  ? 1446 ARG A NH2 1 
ATOM   3244 N N   . ASN D 3 103 ? -69.184 27.398  -73.307  1.00 34.47  ? 1447 ASN A N   1 
ATOM   3245 C CA  . ASN D 3 103 ? -69.832 27.050  -72.048  1.00 28.10  ? 1447 ASN A CA  1 
ATOM   3246 C C   . ASN D 3 103 ? -68.816 26.876  -70.925  1.00 28.00  ? 1447 ASN A C   1 
ATOM   3247 O O   . ASN D 3 103 ? -69.043 27.333  -69.799  1.00 37.38  ? 1447 ASN A O   1 
ATOM   3248 C CB  . ASN D 3 103 ? -70.652 25.779  -72.238  1.00 24.60  ? 1447 ASN A CB  1 
ATOM   3249 C CG  . ASN D 3 103 ? -71.719 25.608  -71.186  1.00 34.59  ? 1447 ASN A CG  1 
ATOM   3250 O OD1 . ASN D 3 103 ? -71.456 25.104  -70.093  1.00 36.78  ? 1447 ASN A OD1 1 
ATOM   3251 N ND2 . ASN D 3 103 ? -72.940 26.016  -71.513  1.00 39.12  ? 1447 ASN A ND2 1 
ATOM   3252 N N   . LEU D 3 104 ? -67.687 26.224  -71.210  1.00 27.23  ? 1448 LEU A N   1 
ATOM   3253 C CA  . LEU D 3 104 ? -66.715 25.949  -70.156  1.00 30.92  ? 1448 LEU A CA  1 
ATOM   3254 C C   . LEU D 3 104 ? -65.872 27.176  -69.825  1.00 27.48  ? 1448 LEU A C   1 
ATOM   3255 O O   . LEU D 3 104 ? -65.575 27.424  -68.650  1.00 31.14  ? 1448 LEU A O   1 
ATOM   3256 C CB  . LEU D 3 104 ? -65.821 24.776  -70.555  1.00 30.53  ? 1448 LEU A CB  1 
ATOM   3257 C CG  . LEU D 3 104 ? -66.145 23.458  -69.847  1.00 27.07  ? 1448 LEU A CG  1 
ATOM   3258 C CD1 . LEU D 3 104 ? -67.635 23.163  -69.932  1.00 33.17  ? 1448 LEU A CD1 1 
ATOM   3259 C CD2 . LEU D 3 104 ? -65.336 22.314  -70.435  1.00 24.74  ? 1448 LEU A CD2 1 
ATOM   3260 N N   . THR D 3 105 ? -65.472 27.950  -70.837  1.00 23.12  ? 1449 THR A N   1 
ATOM   3261 C CA  . THR D 3 105 ? -64.701 29.162  -70.570  1.00 21.93  ? 1449 THR A CA  1 
ATOM   3262 C C   . THR D 3 105 ? -65.522 30.160  -69.762  1.00 36.73  ? 1449 THR A C   1 
ATOM   3263 O O   . THR D 3 105 ? -65.037 30.721  -68.771  1.00 32.13  ? 1449 THR A O   1 
ATOM   3264 C CB  . THR D 3 105 ? -64.225 29.796  -71.878  1.00 27.85  ? 1449 THR A CB  1 
ATOM   3265 O OG1 . THR D 3 105 ? -63.805 28.772  -72.789  1.00 40.52  ? 1449 THR A OG1 1 
ATOM   3266 C CG2 . THR D 3 105 ? -63.062 30.741  -71.616  1.00 24.74  ? 1449 THR A CG2 1 
ATOM   3267 N N   . ALA D 3 106 ? -66.776 30.387  -70.171  1.00 35.53  ? 1450 ALA A N   1 
ATOM   3268 C CA  . ALA D 3 106 ? -67.639 31.308  -69.437  1.00 28.02  ? 1450 ALA A CA  1 
ATOM   3269 C C   . ALA D 3 106 ? -67.815 30.864  -67.993  1.00 28.61  ? 1450 ALA A C   1 
ATOM   3270 O O   . ALA D 3 106 ? -67.821 31.694  -67.075  1.00 43.71  ? 1450 ALA A O   1 
ATOM   3271 C CB  . ALA D 3 106 ? -68.995 31.427  -70.128  1.00 27.65  ? 1450 ALA A CB  1 
ATOM   3272 N N   . GLY D 3 107 ? -67.958 29.556  -67.771  1.00 22.38  ? 1451 GLY A N   1 
ATOM   3273 C CA  . GLY D 3 107 ? -68.015 29.056  -66.408  1.00 28.90  ? 1451 GLY A CA  1 
ATOM   3274 C C   . GLY D 3 107 ? -66.756 29.373  -65.624  1.00 17.15  ? 1451 GLY A C   1 
ATOM   3275 O O   . GLY D 3 107 ? -66.816 29.936  -64.528  1.00 27.15  ? 1451 GLY A O   1 
ATOM   3276 N N   . MET D 3 108 ? -65.593 29.023  -66.182  1.00 14.13  ? 1452 MET A N   1 
ATOM   3277 C CA  . MET D 3 108 ? -64.337 29.283  -65.486  1.00 20.89  ? 1452 MET A CA  1 
ATOM   3278 C C   . MET D 3 108 ? -64.133 30.769  -65.236  1.00 31.35  ? 1452 MET A C   1 
ATOM   3279 O O   . MET D 3 108 ? -63.523 31.150  -64.231  1.00 36.07  ? 1452 MET A O   1 
ATOM   3280 C CB  . MET D 3 108 ? -63.157 28.714  -66.276  1.00 28.30  ? 1452 MET A CB  1 
ATOM   3281 C CG  . MET D 3 108 ? -62.835 27.258  -65.961  1.00 35.51  ? 1452 MET A CG  1 
ATOM   3282 S SD  . MET D 3 108 ? -63.331 26.766  -64.296  1.00 33.27  ? 1452 MET A SD  1 
ATOM   3283 C CE  . MET D 3 108 ? -61.792 26.876  -63.399  1.00 33.60  ? 1452 MET A CE  1 
ATOM   3284 N N   . ALA D 3 109 ? -64.633 31.621  -66.134  1.00 31.68  ? 1453 ALA A N   1 
ATOM   3285 C CA  . ALA D 3 109 ? -64.562 33.058  -65.903  1.00 22.66  ? 1453 ALA A CA  1 
ATOM   3286 C C   . ALA D 3 109 ? -65.408 33.455  -64.702  1.00 32.41  ? 1453 ALA A C   1 
ATOM   3287 O O   . ALA D 3 109 ? -64.936 34.165  -63.808  1.00 29.12  ? 1453 ALA A O   1 
ATOM   3288 C CB  . ALA D 3 109 ? -65.006 33.816  -67.153  1.00 28.89  ? 1453 ALA A CB  1 
ATOM   3289 N N   . MET D 3 110 ? -66.654 32.974  -64.651  1.00 31.62  ? 1454 MET A N   1 
ATOM   3290 C CA  . MET D 3 110 ? -67.573 33.393  -63.597  1.00 31.05  ? 1454 MET A CA  1 
ATOM   3291 C C   . MET D 3 110 ? -67.054 33.017  -62.215  1.00 27.90  ? 1454 MET A C   1 
ATOM   3292 O O   . MET D 3 110 ? -67.209 33.784  -61.258  1.00 38.35  ? 1454 MET A O   1 
ATOM   3293 C CB  . MET D 3 110 ? -68.952 32.784  -63.838  1.00 28.45  ? 1454 MET A CB  1 
ATOM   3294 C CG  . MET D 3 110 ? -69.928 33.007  -62.704  1.00 32.76  ? 1454 MET A CG  1 
ATOM   3295 S SD  . MET D 3 110 ? -71.552 32.340  -63.095  1.00 50.39  ? 1454 MET A SD  1 
ATOM   3296 C CE  . MET D 3 110 ? -71.104 30.719  -63.689  1.00 21.72  ? 1454 MET A CE  1 
ATOM   3297 N N   . ILE D 3 111 ? -66.439 31.841  -62.085  1.00 29.14  ? 1455 ILE A N   1 
ATOM   3298 C CA  . ILE D 3 111 ? -65.879 31.452  -60.794  1.00 27.87  ? 1455 ILE A CA  1 
ATOM   3299 C C   . ILE D 3 111 ? -64.696 32.343  -60.438  1.00 31.45  ? 1455 ILE A C   1 
ATOM   3300 O O   . ILE D 3 111 ? -64.545 32.771  -59.287  1.00 39.14  ? 1455 ILE A O   1 
ATOM   3301 C CB  . ILE D 3 111 ? -65.489 29.962  -60.802  1.00 17.80  ? 1455 ILE A CB  1 
ATOM   3302 C CG1 . ILE D 3 111 ? -66.722 29.080  -61.006  1.00 19.88  ? 1455 ILE A CG1 1 
ATOM   3303 C CG2 . ILE D 3 111 ? -64.795 29.585  -59.508  1.00 31.99  ? 1455 ILE A CG2 1 
ATOM   3304 C CD1 . ILE D 3 111 ? -67.983 29.591  -60.327  1.00 28.76  ? 1455 ILE A CD1 1 
ATOM   3305 N N   . THR D 3 112 ? -63.851 32.653  -61.422  1.00 21.57  ? 1456 THR A N   1 
ATOM   3306 C CA  . THR D 3 112 ? -62.674 33.478  -61.178  1.00 28.32  ? 1456 THR A CA  1 
ATOM   3307 C C   . THR D 3 112 ? -63.020 34.955  -61.026  1.00 36.40  ? 1456 THR A C   1 
ATOM   3308 O O   . THR D 3 112 ? -62.281 35.696  -60.368  1.00 40.18  ? 1456 THR A O   1 
ATOM   3309 C CB  . THR D 3 112 ? -61.670 33.303  -62.324  1.00 30.49  ? 1456 THR A CB  1 
ATOM   3310 O OG1 . THR D 3 112 ? -61.709 31.951  -62.801  1.00 23.77  ? 1456 THR A OG1 1 
ATOM   3311 C CG2 . THR D 3 112 ? -60.255 33.639  -61.869  1.00 39.79  ? 1456 THR A CG2 1 
ATOM   3312 N N   A CYS D 3 113 ? -64.132 35.395  -61.626  0.44 35.98  ? 1457 CYS A N   1 
ATOM   3313 N N   B CYS D 3 113 ? -64.138 35.396  -61.591  0.56 35.96  ? 1457 CYS A N   1 
ATOM   3314 C CA  A CYS D 3 113 ? -64.459 36.817  -61.729  0.44 32.11  ? 1457 CYS A CA  1 
ATOM   3315 C CA  B CYS D 3 113 ? -64.388 36.826  -61.677  0.56 32.09  ? 1457 CYS A CA  1 
ATOM   3316 C C   A CYS D 3 113 ? -65.149 37.341  -60.475  0.44 34.85  ? 1457 CYS A C   1 
ATOM   3317 C C   B CYS D 3 113 ? -65.183 37.373  -60.497  0.56 34.58  ? 1457 CYS A C   1 
ATOM   3318 O O   A CYS D 3 113 ? -64.771 38.392  -59.944  0.44 40.10  ? 1457 CYS A O   1 
ATOM   3319 O O   B CYS D 3 113 ? -64.885 38.472  -60.019  0.56 40.39  ? 1457 CYS A O   1 
ATOM   3320 C CB  A CYS D 3 113 ? -65.375 37.057  -62.930  0.44 30.09  ? 1457 CYS A CB  1 
ATOM   3321 C CB  B CYS D 3 113 ? -65.114 37.146  -62.982  0.56 29.84  ? 1457 CYS A CB  1 
ATOM   3322 S SG  A CYS D 3 113 ? -67.085 36.694  -62.459  0.44 41.58  ? 1457 CYS A SG  1 
ATOM   3323 S SG  B CYS D 3 113 ? -65.167 38.888  -63.359  0.56 40.57  ? 1457 CYS A SG  1 
ATOM   3324 N N   . ARG D 3 114 ? -66.174 36.624  -60.003  1.00 26.66  ? 1458 ARG A N   1 
ATOM   3325 C CA  . ARG D 3 114 ? -67.164 37.199  -59.090  1.00 21.84  ? 1458 ARG A CA  1 
ATOM   3326 C C   . ARG D 3 114 ? -66.537 37.746  -57.814  1.00 40.18  ? 1458 ARG A C   1 
ATOM   3327 O O   . ARG D 3 114 ? -66.655 38.941  -57.516  1.00 43.28  ? 1458 ARG A O   1 
ATOM   3328 C CB  . ARG D 3 114 ? -68.235 36.157  -58.761  1.00 25.05  ? 1458 ARG A CB  1 
ATOM   3329 C CG  . ARG D 3 114 ? -69.203 35.918  -59.901  1.00 34.48  ? 1458 ARG A CG  1 
ATOM   3330 C CD  . ARG D 3 114 ? -70.581 36.483  -59.622  1.00 52.08  ? 1458 ARG A CD  1 
ATOM   3331 N NE  . ARG D 3 114 ? -71.602 35.783  -60.391  1.00 73.51  ? 1458 ARG A NE  1 
ATOM   3332 C CZ  . ARG D 3 114 ? -72.855 36.196  -60.525  1.00 66.96  ? 1458 ARG A CZ  1 
ATOM   3333 N NH1 . ARG D 3 114 ? -73.283 37.305  -59.942  1.00 50.31  ? 1458 ARG A NH1 1 
ATOM   3334 N NH2 . ARG D 3 114 ? -73.699 35.481  -61.264  1.00 61.05  ? 1458 ARG A NH2 1 
ATOM   3335 N N   . GLU D 3 115 ? -65.882 36.885  -57.038  1.00 41.00  ? 1459 GLU A N   1 
ATOM   3336 C CA  . GLU D 3 115 ? -65.373 37.319  -55.738  1.00 43.55  ? 1459 GLU A CA  1 
ATOM   3337 C C   . GLU D 3 115 ? -64.447 38.527  -55.840  1.00 43.11  ? 1459 GLU A C   1 
ATOM   3338 O O   . GLU D 3 115 ? -64.669 39.506  -55.106  1.00 52.05  ? 1459 GLU A O   1 
ATOM   3339 C CB  . GLU D 3 115 ? -64.703 36.138  -55.027  1.00 58.01  ? 1459 GLU A CB  1 
ATOM   3340 C CG  . GLU D 3 115 ? -64.245 36.451  -53.611  1.00 75.51  ? 1459 GLU A CG  1 
ATOM   3341 C CD  . GLU D 3 115 ? -62.900 35.836  -53.282  1.00 78.98  ? 1459 GLU A CD  1 
ATOM   3342 O OE1 . GLU D 3 115 ? -62.593 34.752  -53.824  1.00 75.83  ? 1459 GLU A OE1 1 
ATOM   3343 O OE2 . GLU D 3 115 ? -62.148 36.436  -52.485  1.00 87.88  ? 1459 GLU A OE2 1 
ATOM   3344 N N   . PRO D 3 116 ? -63.431 38.556  -56.713  1.00 42.47  ? 1460 PRO A N   1 
ATOM   3345 C CA  . PRO D 3 116 ? -62.594 39.763  -56.789  1.00 28.08  ? 1460 PRO A CA  1 
ATOM   3346 C C   . PRO D 3 116 ? -63.326 40.967  -57.348  1.00 37.60  ? 1460 PRO A C   1 
ATOM   3347 O O   . PRO D 3 116 ? -63.055 42.093  -56.913  1.00 39.20  ? 1460 PRO A O   1 
ATOM   3348 C CB  . PRO D 3 116 ? -61.440 39.338  -57.709  1.00 27.97  ? 1460 PRO A CB  1 
ATOM   3349 C CG  . PRO D 3 116 ? -61.471 37.854  -57.720  1.00 41.54  ? 1460 PRO A CG  1 
ATOM   3350 C CD  . PRO D 3 116 ? -62.914 37.500  -57.601  1.00 51.53  ? 1460 PRO A CD  1 
ATOM   3351 N N   . LEU D 3 117 ? -64.237 40.766  -58.303  1.00 35.50  ? 1461 LEU A N   1 
ATOM   3352 C CA  . LEU D 3 117 ? -64.949 41.892  -58.902  1.00 28.93  ? 1461 LEU A CA  1 
ATOM   3353 C C   . LEU D 3 117 ? -65.781 42.634  -57.867  1.00 42.73  ? 1461 LEU A C   1 
ATOM   3354 O O   . LEU D 3 117 ? -65.765 43.869  -57.811  1.00 47.04  ? 1461 LEU A O   1 
ATOM   3355 C CB  . LEU D 3 117 ? -65.841 41.408  -60.037  1.00 19.28  ? 1461 LEU A CB  1 
ATOM   3356 C CG  . LEU D 3 117 ? -65.845 42.286  -61.283  1.00 22.20  ? 1461 LEU A CG  1 
ATOM   3357 C CD1 . LEU D 3 117 ? -64.443 42.399  -61.871  1.00 23.97  ? 1461 LEU A CD1 1 
ATOM   3358 C CD2 . LEU D 3 117 ? -66.825 41.723  -62.290  1.00 27.94  ? 1461 LEU A CD2 1 
ATOM   3359 N N   . LEU D 3 118 ? -66.526 41.894  -57.043  1.00 41.42  ? 1462 LEU A N   1 
ATOM   3360 C CA  . LEU D 3 118 ? -67.352 42.535  -56.027  1.00 30.69  ? 1462 LEU A CA  1 
ATOM   3361 C C   . LEU D 3 118 ? -66.499 43.349  -55.065  1.00 33.65  ? 1462 LEU A C   1 
ATOM   3362 O O   . LEU D 3 118 ? -66.915 44.419  -54.606  1.00 46.24  ? 1462 LEU A O   1 
ATOM   3363 C CB  . LEU D 3 118 ? -68.163 41.482  -55.274  1.00 36.59  ? 1462 LEU A CB  1 
ATOM   3364 C CG  . LEU D 3 118 ? -69.554 41.909  -54.804  1.00 35.07  ? 1462 LEU A CG  1 
ATOM   3365 C CD1 . LEU D 3 118 ? -70.412 40.686  -54.528  1.00 43.77  ? 1462 LEU A CD1 1 
ATOM   3366 C CD2 . LEU D 3 118 ? -69.468 42.788  -53.575  1.00 43.12  ? 1462 LEU A CD2 1 
ATOM   3367 N N   . MET D 3 119 ? -65.296 42.862  -54.755  1.00 34.39  ? 1463 MET A N   1 
ATOM   3368 C CA  . MET D 3 119 ? -64.379 43.641  -53.930  1.00 45.92  ? 1463 MET A CA  1 
ATOM   3369 C C   . MET D 3 119 ? -63.758 44.786  -54.723  1.00 49.95  ? 1463 MET A C   1 
ATOM   3370 O O   . MET D 3 119 ? -63.614 45.899  -54.205  1.00 50.14  ? 1463 MET A O   1 
ATOM   3371 C CB  . MET D 3 119 ? -63.292 42.736  -53.351  1.00 57.30  ? 1463 MET A CB  1 
ATOM   3372 C CG  . MET D 3 119 ? -63.663 42.087  -52.029  1.00 61.03  ? 1463 MET A CG  1 
ATOM   3373 S SD  . MET D 3 119 ? -63.768 43.294  -50.693  1.00 115.87 ? 1463 MET A SD  1 
ATOM   3374 C CE  . MET D 3 119 ? -62.077 43.887  -50.635  1.00 56.54  ? 1463 MET A CE  1 
ATOM   3375 N N   . SER D 3 120 ? -63.388 44.535  -55.983  1.00 42.74  ? 1464 SER A N   1 
ATOM   3376 C CA  . SER D 3 120 ? -62.796 45.586  -56.806  1.00 42.82  ? 1464 SER A CA  1 
ATOM   3377 C C   . SER D 3 120 ? -63.791 46.705  -57.085  1.00 49.27  ? 1464 SER A C   1 
ATOM   3378 O O   . SER D 3 120 ? -63.418 47.884  -57.093  1.00 54.62  ? 1464 SER A O   1 
ATOM   3379 C CB  . SER D 3 120 ? -62.277 44.999  -58.118  1.00 44.99  ? 1464 SER A CB  1 
ATOM   3380 O OG  . SER D 3 120 ? -61.364 45.885  -58.745  1.00 59.05  ? 1464 SER A OG  1 
ATOM   3381 N N   . ILE D 3 121 ? -65.056 46.358  -57.327  1.00 50.04  ? 1465 ILE A N   1 
ATOM   3382 C CA  . ILE D 3 121 ? -66.070 47.378  -57.576  1.00 36.62  ? 1465 ILE A CA  1 
ATOM   3383 C C   . ILE D 3 121 ? -66.298 48.215  -56.326  1.00 28.74  ? 1465 ILE A C   1 
ATOM   3384 O O   . ILE D 3 121 ? -66.235 49.449  -56.365  1.00 41.44  ? 1465 ILE A O   1 
ATOM   3385 C CB  . ILE D 3 121 ? -67.380 46.731  -58.055  1.00 26.74  ? 1465 ILE A CB  1 
ATOM   3386 C CG1 . ILE D 3 121 ? -67.212 46.143  -59.454  1.00 28.43  ? 1465 ILE A CG1 1 
ATOM   3387 C CG2 . ILE D 3 121 ? -68.503 47.752  -58.036  1.00 23.64  ? 1465 ILE A CG2 1 
ATOM   3388 C CD1 . ILE D 3 121 ? -68.494 45.565  -60.023  1.00 29.76  ? 1465 ILE A CD1 1 
ATOM   3389 N N   . SER D 3 122 ? -66.573 47.556  -55.199  1.00 31.16  ? 1466 SER A N   1 
ATOM   3390 C CA  . SER D 3 122 ? -66.914 48.289  -53.986  1.00 34.10  ? 1466 SER A CA  1 
ATOM   3391 C C   . SER D 3 122 ? -65.741 49.134  -53.511  1.00 38.88  ? 1466 SER A C   1 
ATOM   3392 O O   . SER D 3 122 ? -65.928 50.272  -53.069  1.00 42.98  ? 1466 SER A O   1 
ATOM   3393 C CB  . SER D 3 122 ? -67.362 47.323  -52.890  1.00 27.07  ? 1466 SER A CB  1 
ATOM   3394 O OG  . SER D 3 122 ? -66.325 47.104  -51.952  1.00 39.53  ? 1466 SER A OG  1 
ATOM   3395 N N   . THR D 3 123 ? -64.522 48.604  -53.615  1.00 41.38  ? 1467 THR A N   1 
ATOM   3396 C CA  . THR D 3 123 ? -63.350 49.357  -53.179  1.00 33.84  ? 1467 THR A CA  1 
ATOM   3397 C C   . THR D 3 123 ? -63.110 50.567  -54.075  1.00 37.90  ? 1467 THR A C   1 
ATOM   3398 O O   . THR D 3 123 ? -62.882 51.678  -53.583  1.00 56.08  ? 1467 THR A O   1 
ATOM   3399 C CB  . THR D 3 123 ? -62.123 48.446  -53.149  1.00 33.33  ? 1467 THR A CB  1 
ATOM   3400 O OG1 . THR D 3 123 ? -62.110 47.711  -51.919  1.00 31.70  ? 1467 THR A OG1 1 
ATOM   3401 C CG2 . THR D 3 123 ? -60.839 49.259  -53.263  1.00 38.25  ? 1467 THR A CG2 1 
ATOM   3402 N N   . ASN D 3 124 ? -63.166 50.377  -55.396  1.00 24.76  ? 1468 ASN A N   1 
ATOM   3403 C CA  . ASN D 3 124 ? -62.995 51.508  -56.304  1.00 33.02  ? 1468 ASN A CA  1 
ATOM   3404 C C   . ASN D 3 124 ? -64.046 52.581  -56.048  1.00 43.12  ? 1468 ASN A C   1 
ATOM   3405 O O   . ASN D 3 124 ? -63.757 53.780  -56.140  1.00 45.54  ? 1468 ASN A O   1 
ATOM   3406 C CB  . ASN D 3 124 ? -63.055 51.036  -57.756  1.00 40.27  ? 1468 ASN A CB  1 
ATOM   3407 C CG  . ASN D 3 124 ? -61.807 50.290  -58.176  1.00 48.15  ? 1468 ASN A CG  1 
ATOM   3408 O OD1 . ASN D 3 124 ? -60.814 50.261  -57.447  1.00 60.36  ? 1468 ASN A OD1 1 
ATOM   3409 N ND2 . ASN D 3 124 ? -61.849 49.681  -59.355  1.00 46.50  ? 1468 ASN A ND2 1 
ATOM   3410 N N   . LEU D 3 125 ? -65.271 52.167  -55.713  1.00 50.98  ? 1469 LEU A N   1 
ATOM   3411 C CA  . LEU D 3 125 ? -66.324 53.129  -55.407  1.00 38.47  ? 1469 LEU A CA  1 
ATOM   3412 C C   . LEU D 3 125 ? -66.016 53.896  -54.127  1.00 38.37  ? 1469 LEU A C   1 
ATOM   3413 O O   . LEU D 3 125 ? -66.346 55.082  -54.012  1.00 41.13  ? 1469 LEU A O   1 
ATOM   3414 C CB  . LEU D 3 125 ? -67.666 52.411  -55.285  1.00 25.25  ? 1469 LEU A CB  1 
ATOM   3415 C CG  . LEU D 3 125 ? -68.335 51.999  -56.594  1.00 14.72  ? 1469 LEU A CG  1 
ATOM   3416 C CD1 . LEU D 3 125 ? -69.309 50.856  -56.351  1.00 29.99  ? 1469 LEU A CD1 1 
ATOM   3417 C CD2 . LEU D 3 125 ? -69.046 53.182  -57.214  1.00 21.90  ? 1469 LEU A CD2 1 
ATOM   3418 N N   . LYS D 3 126 ? -65.385 53.236  -53.155  1.00 34.27  ? 1470 LYS A N   1 
ATOM   3419 C CA  . LYS D 3 126 ? -65.119 53.886  -51.877  1.00 31.51  ? 1470 LYS A CA  1 
ATOM   3420 C C   . LYS D 3 126 ? -64.053 54.969  -52.013  1.00 37.15  ? 1470 LYS A C   1 
ATOM   3421 O O   . LYS D 3 126 ? -64.138 56.014  -51.358  1.00 52.85  ? 1470 LYS A O   1 
ATOM   3422 C CB  . LYS D 3 126 ? -64.709 52.842  -50.835  1.00 36.06  ? 1470 LYS A CB  1 
ATOM   3423 C CG  . LYS D 3 126 ? -65.820 51.852  -50.503  1.00 40.24  ? 1470 LYS A CG  1 
ATOM   3424 C CD  . LYS D 3 126 ? -65.943 51.545  -49.019  1.00 42.94  ? 1470 LYS A CD  1 
ATOM   3425 C CE  . LYS D 3 126 ? -65.652 50.079  -48.729  1.00 50.24  ? 1470 LYS A CE  1 
ATOM   3426 N NZ  . LYS D 3 126 ? -64.920 49.907  -47.438  1.00 71.06  ? 1470 LYS A NZ  1 
ATOM   3427 N N   . ASN D 3 127 ? -63.048 54.749  -52.865  1.00 38.38  ? 1471 ASN A N   1 
ATOM   3428 C CA  . ASN D 3 127 ? -62.012 55.763  -53.044  1.00 36.65  ? 1471 ASN A CA  1 
ATOM   3429 C C   . ASN D 3 127 ? -62.484 56.886  -53.956  1.00 45.31  ? 1471 ASN A C   1 
ATOM   3430 O O   . ASN D 3 127 ? -62.204 58.060  -53.688  1.00 59.80  ? 1471 ASN A O   1 
ATOM   3431 C CB  . ASN D 3 127 ? -60.731 55.136  -53.595  1.00 42.56  ? 1471 ASN A CB  1 
ATOM   3432 C CG  . ASN D 3 127 ? -60.482 53.748  -53.046  1.00 54.18  ? 1471 ASN A CG  1 
ATOM   3433 O OD1 . ASN D 3 127 ? -59.901 53.588  -51.970  1.00 46.49  ? 1471 ASN A OD1 1 
ATOM   3434 N ND2 . ASN D 3 127 ? -60.893 52.733  -53.796  1.00 60.28  ? 1471 ASN A ND2 1 
ATOM   3435 N N   . SER D 3 128 ? -63.187 56.547  -55.041  1.00 39.41  ? 1472 SER A N   1 
ATOM   3436 C CA  . SER D 3 128 ? -63.750 57.580  -55.906  1.00 44.25  ? 1472 SER A CA  1 
ATOM   3437 C C   . SER D 3 128 ? -64.744 58.447  -55.144  1.00 42.17  ? 1472 SER A C   1 
ATOM   3438 O O   . SER D 3 128 ? -64.814 59.662  -55.360  1.00 44.98  ? 1472 SER A O   1 
ATOM   3439 C CB  . SER D 3 128 ? -64.419 56.943  -57.124  1.00 46.46  ? 1472 SER A CB  1 
ATOM   3440 O OG  . SER D 3 128 ? -63.467 56.314  -57.964  1.00 60.72  ? 1472 SER A OG  1 
ATOM   3441 N N   . PHE D 3 129 ? -65.523 57.838  -54.247  1.00 38.32  ? 1473 PHE A N   1 
ATOM   3442 C CA  . PHE D 3 129 ? -66.427 58.618  -53.410  1.00 35.38  ? 1473 PHE A CA  1 
ATOM   3443 C C   . PHE D 3 129 ? -65.650 59.527  -52.468  1.00 48.00  ? 1473 PHE A C   1 
ATOM   3444 O O   . PHE D 3 129 ? -65.981 60.708  -52.316  1.00 67.41  ? 1473 PHE A O   1 
ATOM   3445 C CB  . PHE D 3 129 ? -67.337 57.690  -52.607  1.00 34.94  ? 1473 PHE A CB  1 
ATOM   3446 C CG  . PHE D 3 129 ? -68.509 57.153  -53.380  1.00 26.95  ? 1473 PHE A CG  1 
ATOM   3447 C CD1 . PHE D 3 129 ? -68.884 57.714  -54.589  1.00 34.14  ? 1473 PHE A CD1 1 
ATOM   3448 C CD2 . PHE D 3 129 ? -69.235 56.078  -52.892  1.00 23.97  ? 1473 PHE A CD2 1 
ATOM   3449 C CE1 . PHE D 3 129 ? -69.961 57.214  -55.297  1.00 19.66  ? 1473 PHE A CE1 1 
ATOM   3450 C CE2 . PHE D 3 129 ? -70.311 55.575  -53.593  1.00 30.14  ? 1473 PHE A CE2 1 
ATOM   3451 C CZ  . PHE D 3 129 ? -70.674 56.143  -54.799  1.00 21.95  ? 1473 PHE A CZ  1 
ATOM   3452 N N   . ALA D 3 130 ? -64.606 58.991  -51.830  1.00 51.86  ? 1474 ALA A N   1 
ATOM   3453 C CA  . ALA D 3 130 ? -63.866 59.760  -50.838  1.00 44.66  ? 1474 ALA A CA  1 
ATOM   3454 C C   . ALA D 3 130 ? -63.072 60.894  -51.471  1.00 50.83  ? 1474 ALA A C   1 
ATOM   3455 O O   . ALA D 3 130 ? -62.848 61.923  -50.824  1.00 77.35  ? 1474 ALA A O   1 
ATOM   3456 C CB  . ALA D 3 130 ? -62.935 58.840  -50.048  1.00 40.74  ? 1474 ALA A CB  1 
ATOM   3457 N N   . SER D 3 131 ? -62.643 60.733  -52.725  1.00 48.54  ? 1475 SER A N   1 
ATOM   3458 C CA  . SER D 3 131 ? -61.820 61.760  -53.354  1.00 60.98  ? 1475 SER A CA  1 
ATOM   3459 C C   . SER D 3 131 ? -62.599 63.054  -53.552  1.00 66.02  ? 1475 SER A C   1 
ATOM   3460 O O   . SER D 3 131 ? -62.051 64.149  -53.381  1.00 82.73  ? 1475 SER A O   1 
ATOM   3461 C CB  . SER D 3 131 ? -61.277 61.261  -54.691  1.00 47.17  ? 1475 SER A CB  1 
ATOM   3462 O OG  . SER D 3 131 ? -60.912 62.353  -55.517  1.00 53.81  ? 1475 SER A OG  1 
ATOM   3463 N N   . ALA D 3 132 ? -63.878 62.950  -53.916  1.00 53.75  ? 1476 ALA A N   1 
ATOM   3464 C CA  . ALA D 3 132 ? -64.677 64.151  -54.124  1.00 55.64  ? 1476 ALA A CA  1 
ATOM   3465 C C   . ALA D 3 132 ? -65.239 64.688  -52.812  1.00 65.04  ? 1476 ALA A C   1 
ATOM   3466 O O   . ALA D 3 132 ? -65.338 65.907  -52.632  1.00 79.81  ? 1476 ALA A O   1 
ATOM   3467 C CB  . ALA D 3 132 ? -65.804 63.869  -55.117  1.00 33.81  ? 1476 ALA A CB  1 
ATOM   3468 N N   . LEU D 3 133 ? -65.604 63.799  -51.883  1.00 57.82  ? 1477 LEU A N   1 
ATOM   3469 C CA  . LEU D 3 133 ? -66.168 64.249  -50.613  1.00 67.89  ? 1477 LEU A CA  1 
ATOM   3470 C C   . LEU D 3 133 ? -65.128 64.956  -49.755  1.00 81.81  ? 1477 LEU A C   1 
ATOM   3471 O O   . LEU D 3 133 ? -65.433 65.969  -49.113  1.00 93.07  ? 1477 LEU A O   1 
ATOM   3472 C CB  . LEU D 3 133 ? -66.769 63.072  -49.849  1.00 69.85  ? 1477 LEU A CB  1 
ATOM   3473 C CG  . LEU D 3 133 ? -68.296 63.002  -49.860  1.00 75.38  ? 1477 LEU A CG  1 
ATOM   3474 C CD1 . LEU D 3 133 ? -68.775 61.625  -49.440  1.00 70.32  ? 1477 LEU A CD1 1 
ATOM   3475 C CD2 . LEU D 3 133 ? -68.890 64.079  -48.964  1.00 73.34  ? 1477 LEU A CD2 1 
ATOM   3476 N N   . ARG D 3 134 ? -63.905 64.420  -49.706  1.00 77.00  ? 1478 ARG A N   1 
ATOM   3477 C CA  . ARG D 3 134 ? -62.775 65.042  -49.020  1.00 73.33  ? 1478 ARG A CA  1 
ATOM   3478 C C   . ARG D 3 134 ? -63.002 65.181  -47.517  1.00 79.53  ? 1478 ARG A C   1 
ATOM   3479 O O   . ARG D 3 134 ? -62.158 64.759  -46.720  1.00 76.97  ? 1478 ARG A O   1 
ATOM   3480 C CB  . ARG D 3 134 ? -62.470 66.417  -49.630  1.00 88.62  ? 1478 ARG A CB  1 
ATOM   3481 C CG  . ARG D 3 134 ? -62.450 66.440  -51.153  1.00 86.63  ? 1478 ARG A CG  1 
ATOM   3482 C CD  . ARG D 3 134 ? -61.105 66.894  -51.703  1.00 103.06 ? 1478 ARG A CD  1 
ATOM   3483 N NE  . ARG D 3 134 ? -61.051 68.341  -51.886  1.00 107.15 ? 1478 ARG A NE  1 
ATOM   3484 C CZ  . ARG D 3 134 ? -61.600 68.991  -52.904  1.00 102.55 ? 1478 ARG A CZ  1 
ATOM   3485 N NH1 . ARG D 3 134 ? -62.265 68.354  -53.854  1.00 79.73  ? 1478 ARG A NH1 1 
ATOM   3486 N NH2 . ARG D 3 134 ? -61.479 70.314  -52.970  1.00 103.66 ? 1478 ARG A NH2 1 
ATOM   3487 N N   . THR D 3 135 ? -64.131 65.779  -47.125  1.00 81.45  ? 1479 THR A N   1 
ATOM   3488 C CA  . THR D 3 135 ? -64.379 66.068  -45.715  1.00 94.36  ? 1479 THR A CA  1 
ATOM   3489 C C   . THR D 3 135 ? -64.330 64.798  -44.873  1.00 92.25  ? 1479 THR A C   1 
ATOM   3490 O O   . THR D 3 135 ? -63.700 64.769  -43.810  1.00 105.39 ? 1479 THR A O   1 
ATOM   3491 C CB  . THR D 3 135 ? -65.728 66.773  -45.554  1.00 93.26  ? 1479 THR A CB  1 
ATOM   3492 O OG1 . THR D 3 135 ? -65.962 67.624  -46.682  1.00 81.97  ? 1479 THR A OG1 1 
ATOM   3493 C CG2 . THR D 3 135 ? -65.738 67.613  -44.283  1.00 79.23  ? 1479 THR A CG2 1 
ATOM   3494 N N   . ALA D 3 136 ? -64.997 63.738  -45.336  1.00 69.63  ? 1480 ALA A N   1 
ATOM   3495 C CA  . ALA D 3 136 ? -64.925 62.410  -44.727  1.00 62.06  ? 1480 ALA A CA  1 
ATOM   3496 C C   . ALA D 3 136 ? -65.370 62.432  -43.262  1.00 63.18  ? 1480 ALA A C   1 
ATOM   3497 O O   . ALA D 3 136 ? -64.631 62.052  -42.352  1.00 73.61  ? 1480 ALA A O   1 
ATOM   3498 C CB  . ALA D 3 136 ? -63.514 61.824  -44.865  1.00 70.69  ? 1480 ALA A CB  1 
ATOM   3499 N N   . SER D 3 137 ? -66.604 62.885  -43.046  1.00 68.93  ? 1481 SER A N   1 
ATOM   3500 C CA  . SER D 3 137 ? -67.153 62.783  -41.704  1.00 61.03  ? 1481 SER A CA  1 
ATOM   3501 C C   . SER D 3 137 ? -67.608 61.348  -41.441  1.00 46.74  ? 1481 SER A C   1 
ATOM   3502 O O   . SER D 3 137 ? -67.941 60.619  -42.379  1.00 56.50  ? 1481 SER A O   1 
ATOM   3503 C CB  . SER D 3 137 ? -68.326 63.742  -41.524  1.00 71.68  ? 1481 SER A CB  1 
ATOM   3504 O OG  . SER D 3 137 ? -69.071 63.870  -42.718  1.00 72.01  ? 1481 SER A OG  1 
ATOM   3505 N N   . PRO D 3 138 ? -67.623 60.918  -40.174  1.00 48.96  ? 1482 PRO A N   1 
ATOM   3506 C CA  . PRO D 3 138 ? -67.961 59.512  -39.883  1.00 61.45  ? 1482 PRO A CA  1 
ATOM   3507 C C   . PRO D 3 138 ? -69.299 59.076  -40.445  1.00 69.41  ? 1482 PRO A C   1 
ATOM   3508 O O   . PRO D 3 138 ? -69.451 57.906  -40.820  1.00 69.67  ? 1482 PRO A O   1 
ATOM   3509 C CB  . PRO D 3 138 ? -67.955 59.465  -38.349  1.00 48.75  ? 1482 PRO A CB  1 
ATOM   3510 C CG  . PRO D 3 138 ? -67.027 60.555  -37.957  1.00 70.98  ? 1482 PRO A CG  1 
ATOM   3511 C CD  . PRO D 3 138 ? -67.275 61.657  -38.949  1.00 70.06  ? 1482 PRO A CD  1 
ATOM   3512 N N   . GLN D 3 139 ? -70.280 59.977  -40.512  1.00 62.44  ? 1483 GLN A N   1 
ATOM   3513 C CA  . GLN D 3 139 ? -71.510 59.656  -41.223  1.00 40.89  ? 1483 GLN A CA  1 
ATOM   3514 C C   . GLN D 3 139 ? -71.234 59.457  -42.705  1.00 46.66  ? 1483 GLN A C   1 
ATOM   3515 O O   . GLN D 3 139 ? -71.536 58.398  -43.267  1.00 63.46  ? 1483 GLN A O   1 
ATOM   3516 C CB  . GLN D 3 139 ? -72.547 60.755  -41.010  1.00 38.30  ? 1483 GLN A CB  1 
ATOM   3517 C CG  . GLN D 3 139 ? -73.464 60.499  -39.835  1.00 45.72  ? 1483 GLN A CG  1 
ATOM   3518 C CD  . GLN D 3 139 ? -74.598 61.494  -39.768  1.00 54.18  ? 1483 GLN A CD  1 
ATOM   3519 O OE1 . GLN D 3 139 ? -74.877 62.200  -40.738  1.00 45.55  ? 1483 GLN A OE1 1 
ATOM   3520 N NE2 . GLN D 3 139 ? -75.259 61.560  -38.618  1.00 73.55  ? 1483 GLN A NE2 1 
ATOM   3521 N N   . GLN D 3 140 ? -70.630 60.463  -43.349  1.00 50.91  ? 1484 GLN A N   1 
ATOM   3522 C CA  . GLN D 3 140 ? -70.325 60.372  -44.775  1.00 53.57  ? 1484 GLN A CA  1 
ATOM   3523 C C   . GLN D 3 140 ? -69.504 59.130  -45.101  1.00 57.58  ? 1484 GLN A C   1 
ATOM   3524 O O   . GLN D 3 140 ? -69.590 58.604  -46.218  1.00 57.85  ? 1484 GLN A O   1 
ATOM   3525 C CB  . GLN D 3 140 ? -69.590 61.633  -45.233  1.00 59.32  ? 1484 GLN A CB  1 
ATOM   3526 C CG  . GLN D 3 140 ? -70.494 62.830  -45.491  1.00 56.39  ? 1484 GLN A CG  1 
ATOM   3527 C CD  . GLN D 3 140 ? -69.731 64.141  -45.497  1.00 71.67  ? 1484 GLN A CD  1 
ATOM   3528 O OE1 . GLN D 3 140 ? -68.501 64.157  -45.422  1.00 69.43  ? 1484 GLN A OE1 1 
ATOM   3529 N NE2 . GLN D 3 140 ? -70.458 65.250  -45.575  1.00 84.44  ? 1484 GLN A NE2 1 
ATOM   3530 N N   . ARG D 3 141 ? -68.706 58.649  -44.146  1.00 63.09  ? 1485 ARG A N   1 
ATOM   3531 C CA  . ARG D 3 141 ? -68.024 57.373  -44.320  1.00 56.42  ? 1485 ARG A CA  1 
ATOM   3532 C C   . ARG D 3 141 ? -69.034 56.248  -44.515  1.00 60.45  ? 1485 ARG A C   1 
ATOM   3533 O O   . ARG D 3 141 ? -69.098 55.635  -45.585  1.00 72.59  ? 1485 ARG A O   1 
ATOM   3534 C CB  . ARG D 3 141 ? -67.120 57.100  -43.116  1.00 59.16  ? 1485 ARG A CB  1 
ATOM   3535 C CG  . ARG D 3 141 ? -65.639 57.343  -43.372  1.00 72.56  ? 1485 ARG A CG  1 
ATOM   3536 C CD  . ARG D 3 141 ? -65.004 56.270  -44.245  1.00 92.02  ? 1485 ARG A CD  1 
ATOM   3537 N NE  . ARG D 3 141 ? -63.833 56.773  -44.954  1.00 113.93 ? 1485 ARG A NE  1 
ATOM   3538 C CZ  . ARG D 3 141 ? -63.403 56.308  -46.120  1.00 105.85 ? 1485 ARG A CZ  1 
ATOM   3539 N NH1 . ARG D 3 141 ? -63.989 55.281  -46.711  1.00 80.36  ? 1485 ARG A NH1 1 
ATOM   3540 N NH2 . ARG D 3 141 ? -62.350 56.878  -46.699  1.00 86.42  ? 1485 ARG A NH2 1 
ATOM   3541 N N   . GLU D 3 142 ? -69.862 55.988  -43.495  1.00 44.80  ? 1486 GLU A N   1 
ATOM   3542 C CA  . GLU D 3 142 ? -70.845 54.909  -43.583  1.00 43.21  ? 1486 GLU A CA  1 
ATOM   3543 C C   . GLU D 3 142 ? -71.760 55.066  -44.797  1.00 48.36  ? 1486 GLU A C   1 
ATOM   3544 O O   . GLU D 3 142 ? -72.161 54.069  -45.409  1.00 45.30  ? 1486 GLU A O   1 
ATOM   3545 C CB  . GLU D 3 142 ? -71.671 54.841  -42.299  1.00 53.95  ? 1486 GLU A CB  1 
ATOM   3546 C CG  . GLU D 3 142 ? -72.214 53.451  -41.996  1.00 70.71  ? 1486 GLU A CG  1 
ATOM   3547 C CD  . GLU D 3 142 ? -72.948 53.382  -40.670  1.00 99.87  ? 1486 GLU A CD  1 
ATOM   3548 O OE1 . GLU D 3 142 ? -72.961 52.296  -40.051  1.00 93.20  ? 1486 GLU A OE1 1 
ATOM   3549 O OE2 . GLU D 3 142 ? -73.514 54.413  -40.248  1.00 109.78 ? 1486 GLU A OE2 1 
ATOM   3550 N N   . MET D 3 143 ? -72.118 56.306  -45.148  1.00 47.44  ? 1487 MET A N   1 
ATOM   3551 C CA  . MET D 3 143 ? -72.811 56.555  -46.412  1.00 40.48  ? 1487 MET A CA  1 
ATOM   3552 C C   . MET D 3 143 ? -72.047 55.961  -47.593  1.00 46.79  ? 1487 MET A C   1 
ATOM   3553 O O   . MET D 3 143 ? -72.653 55.406  -48.518  1.00 48.91  ? 1487 MET A O   1 
ATOM   3554 C CB  . MET D 3 143 ? -73.010 58.062  -46.612  1.00 53.50  ? 1487 MET A CB  1 
ATOM   3555 C CG  . MET D 3 143 ? -73.659 58.838  -45.459  1.00 39.88  ? 1487 MET A CG  1 
ATOM   3556 S SD  . MET D 3 143 ? -74.351 60.430  -46.001  1.00 55.42  ? 1487 MET A SD  1 
ATOM   3557 C CE  . MET D 3 143 ? -76.097 60.144  -46.260  1.00 43.93  ? 1487 MET A CE  1 
ATOM   3558 N N   . MET D 3 144 ? -70.714 56.071  -47.580  1.00 43.34  ? 1488 MET A N   1 
ATOM   3559 C CA  . MET D 3 144 ? -69.909 55.604  -48.708  1.00 41.08  ? 1488 MET A CA  1 
ATOM   3560 C C   . MET D 3 144 ? -69.835 54.083  -48.750  1.00 41.95  ? 1488 MET A C   1 
ATOM   3561 O O   . MET D 3 144 ? -70.085 53.469  -49.794  1.00 40.22  ? 1488 MET A O   1 
ATOM   3562 C CB  . MET D 3 144 ? -68.503 56.199  -48.632  1.00 38.57  ? 1488 MET A CB  1 
ATOM   3563 C CG  . MET D 3 144 ? -68.347 57.512  -49.360  1.00 39.19  ? 1488 MET A CG  1 
ATOM   3564 S SD  . MET D 3 144 ? -67.223 58.668  -48.561  1.00 44.23  ? 1488 MET A SD  1 
ATOM   3565 C CE  . MET D 3 144 ? -65.986 57.558  -47.911  1.00 68.23  ? 1488 MET A CE  1 
ATOM   3566 N N   . ASP D 3 145 ? -69.463 53.460  -47.628  1.00 47.38  ? 1489 ASP A N   1 
ATOM   3567 C CA  . ASP D 3 145 ? -69.373 52.004  -47.587  1.00 47.12  ? 1489 ASP A CA  1 
ATOM   3568 C C   . ASP D 3 145 ? -70.727 51.357  -47.848  1.00 45.67  ? 1489 ASP A C   1 
ATOM   3569 O O   . ASP D 3 145 ? -70.809 50.331  -48.535  1.00 53.55  ? 1489 ASP A O   1 
ATOM   3570 C CB  . ASP D 3 145 ? -68.801 51.546  -46.244  1.00 58.33  ? 1489 ASP A CB  1 
ATOM   3571 C CG  . ASP D 3 145 ? -67.555 52.316  -45.843  1.00 72.09  ? 1489 ASP A CG  1 
ATOM   3572 O OD1 . ASP D 3 145 ? -67.541 53.556  -45.986  1.00 68.63  ? 1489 ASP A OD1 1 
ATOM   3573 O OD2 . ASP D 3 145 ? -66.587 51.679  -45.376  1.00 89.82  ? 1489 ASP A OD2 1 
ATOM   3574 N N   . GLN D 3 146 ? -71.801 51.945  -47.318  1.00 39.84  ? 1490 GLN A N   1 
ATOM   3575 C CA  . GLN D 3 146 ? -73.132 51.415  -47.595  1.00 53.31  ? 1490 GLN A CA  1 
ATOM   3576 C C   . GLN D 3 146 ? -73.493 51.578  -49.067  1.00 56.26  ? 1490 GLN A C   1 
ATOM   3577 O O   . GLN D 3 146 ? -74.112 50.687  -49.663  1.00 53.26  ? 1490 GLN A O   1 
ATOM   3578 C CB  . GLN D 3 146 ? -74.167 52.100  -46.701  1.00 47.74  ? 1490 GLN A CB  1 
ATOM   3579 C CG  . GLN D 3 146 ? -75.596 51.657  -46.951  1.00 49.30  ? 1490 GLN A CG  1 
ATOM   3580 C CD  . GLN D 3 146 ? -76.333 52.578  -47.902  1.00 60.36  ? 1490 GLN A CD  1 
ATOM   3581 O OE1 . GLN D 3 146 ? -75.835 53.647  -48.266  1.00 56.43  ? 1490 GLN A OE1 1 
ATOM   3582 N NE2 . GLN D 3 146 ? -77.521 52.158  -48.324  1.00 54.83  ? 1490 GLN A NE2 1 
ATOM   3583 N N   . ALA D 3 147 ? -73.114 52.706  -49.672  1.00 51.69  ? 1491 ALA A N   1 
ATOM   3584 C CA  . ALA D 3 147 ? -73.380 52.909  -51.093  1.00 41.87  ? 1491 ALA A CA  1 
ATOM   3585 C C   . ALA D 3 147 ? -72.512 51.994  -51.949  1.00 35.85  ? 1491 ALA A C   1 
ATOM   3586 O O   . ALA D 3 147 ? -73.000 51.363  -52.894  1.00 38.82  ? 1491 ALA A O   1 
ATOM   3587 C CB  . ALA D 3 147 ? -73.151 54.374  -51.467  1.00 35.98  ? 1491 ALA A CB  1 
ATOM   3588 N N   . ALA D 3 148 ? -71.218 51.911  -51.631  1.00 35.31  ? 1492 ALA A N   1 
ATOM   3589 C CA  . ALA D 3 148 ? -70.318 51.071  -52.413  1.00 34.78  ? 1492 ALA A CA  1 
ATOM   3590 C C   . ALA D 3 148 ? -70.716 49.606  -52.328  1.00 37.75  ? 1492 ALA A C   1 
ATOM   3591 O O   . ALA D 3 148 ? -70.606 48.867  -53.314  1.00 38.59  ? 1492 ALA A O   1 
ATOM   3592 C CB  . ALA D 3 148 ? -68.881 51.261  -51.937  1.00 41.18  ? 1492 ALA A CB  1 
ATOM   3593 N N   . ALA D 3 149 ? -71.177 49.166  -51.156  1.00 42.04  ? 1493 ALA A N   1 
ATOM   3594 C CA  . ALA D 3 149 ? -71.644 47.791  -51.013  1.00 47.38  ? 1493 ALA A CA  1 
ATOM   3595 C C   . ALA D 3 149 ? -72.901 47.553  -51.839  1.00 40.86  ? 1493 ALA A C   1 
ATOM   3596 O O   . ALA D 3 149 ? -73.013 46.542  -52.545  1.00 40.05  ? 1493 ALA A O   1 
ATOM   3597 C CB  . ALA D 3 149 ? -71.899 47.474  -49.540  1.00 53.37  ? 1493 ALA A CB  1 
ATOM   3598 N N   . GLN D 3 150 ? -73.862 48.477  -51.763  1.00 30.37  ? 1494 GLN A N   1 
ATOM   3599 C CA  . GLN D 3 150 ? -75.103 48.311  -52.510  1.00 23.51  ? 1494 GLN A CA  1 
ATOM   3600 C C   . GLN D 3 150 ? -74.844 48.282  -54.007  1.00 32.70  ? 1494 GLN A C   1 
ATOM   3601 O O   . GLN D 3 150 ? -75.391 47.435  -54.724  1.00 49.07  ? 1494 GLN A O   1 
ATOM   3602 C CB  . GLN D 3 150 ? -76.081 49.430  -52.163  1.00 27.99  ? 1494 GLN A CB  1 
ATOM   3603 C CG  . GLN D 3 150 ? -77.339 49.421  -53.010  1.00 30.51  ? 1494 GLN A CG  1 
ATOM   3604 C CD  . GLN D 3 150 ? -78.386 48.458  -52.482  1.00 60.24  ? 1494 GLN A CD  1 
ATOM   3605 O OE1 . GLN D 3 150 ? -78.180 47.793  -51.466  1.00 71.55  ? 1494 GLN A OE1 1 
ATOM   3606 N NE2 . GLN D 3 150 ? -79.518 48.379  -53.173  1.00 65.81  ? 1494 GLN A NE2 1 
ATOM   3607 N N   . LEU D 3 151 ? -74.001 49.191  -54.496  1.00 37.63  ? 1495 LEU A N   1 
ATOM   3608 C CA  . LEU D 3 151 ? -73.754 49.278  -55.931  1.00 31.47  ? 1495 LEU A CA  1 
ATOM   3609 C C   . LEU D 3 151 ? -72.968 48.076  -56.439  1.00 33.55  ? 1495 LEU A C   1 
ATOM   3610 O O   . LEU D 3 151 ? -73.226 47.580  -57.542  1.00 42.97  ? 1495 LEU A O   1 
ATOM   3611 C CB  . LEU D 3 151 ? -73.016 50.575  -56.249  1.00 26.01  ? 1495 LEU A CB  1 
ATOM   3612 C CG  . LEU D 3 151 ? -73.858 51.834  -56.066  1.00 21.41  ? 1495 LEU A CG  1 
ATOM   3613 C CD1 . LEU D 3 151 ? -73.005 53.068  -56.294  1.00 22.41  ? 1495 LEU A CD1 1 
ATOM   3614 C CD2 . LEU D 3 151 ? -75.050 51.805  -57.016  1.00 31.54  ? 1495 LEU A CD2 1 
ATOM   3615 N N   . ALA D 3 152 ? -71.999 47.598  -55.653  1.00 35.10  ? 1496 ALA A N   1 
ATOM   3616 C CA  . ALA D 3 152 ? -71.228 46.429  -56.061  1.00 28.39  ? 1496 ALA A CA  1 
ATOM   3617 C C   . ALA D 3 152 ? -72.128 45.211  -56.217  1.00 34.07  ? 1496 ALA A C   1 
ATOM   3618 O O   . ALA D 3 152 ? -72.037 44.478  -57.208  1.00 44.38  ? 1496 ALA A O   1 
ATOM   3619 C CB  . ALA D 3 152 ? -70.115 46.151  -55.051  1.00 33.51  ? 1496 ALA A CB  1 
ATOM   3620 N N   . GLN D 3 153 ? -73.012 44.984  -55.244  1.00 38.79  ? 1497 GLN A N   1 
ATOM   3621 C CA  . GLN D 3 153 ? -73.930 43.854  -55.332  1.00 42.61  ? 1497 GLN A CA  1 
ATOM   3622 C C   . GLN D 3 153 ? -74.860 43.992  -56.531  1.00 41.12  ? 1497 GLN A C   1 
ATOM   3623 O O   . GLN D 3 153 ? -75.183 42.999  -57.192  1.00 46.56  ? 1497 GLN A O   1 
ATOM   3624 C CB  . GLN D 3 153 ? -74.732 43.734  -54.036  1.00 55.77  ? 1497 GLN A CB  1 
ATOM   3625 C CG  . GLN D 3 153 ? -75.158 42.316  -53.692  1.00 73.71  ? 1497 GLN A CG  1 
ATOM   3626 C CD  . GLN D 3 153 ? -76.560 42.259  -53.116  1.00 95.20  ? 1497 GLN A CD  1 
ATOM   3627 O OE1 . GLN D 3 153 ? -77.303 43.239  -53.168  1.00 97.04  ? 1497 GLN A OE1 1 
ATOM   3628 N NE2 . GLN D 3 153 ? -76.931 41.106  -52.567  1.00 92.58  ? 1497 GLN A NE2 1 
ATOM   3629 N N   . ASP D 3 154 ? -75.284 45.221  -56.839  1.00 41.96  ? 1498 ASP A N   1 
ATOM   3630 C CA  . ASP D 3 154 ? -76.248 45.429  -57.915  1.00 37.68  ? 1498 ASP A CA  1 
ATOM   3631 C C   . ASP D 3 154 ? -75.637 45.186  -59.289  1.00 46.40  ? 1498 ASP A C   1 
ATOM   3632 O O   . ASP D 3 154 ? -76.332 44.723  -60.201  1.00 57.95  ? 1498 ASP A O   1 
ATOM   3633 C CB  . ASP D 3 154 ? -76.820 46.847  -57.851  1.00 52.10  ? 1498 ASP A CB  1 
ATOM   3634 C CG  . ASP D 3 154 ? -77.800 47.040  -56.707  1.00 53.06  ? 1498 ASP A CG  1 
ATOM   3635 O OD1 . ASP D 3 154 ? -78.167 46.040  -56.052  1.00 65.05  ? 1498 ASP A OD1 1 
ATOM   3636 O OD2 . ASP D 3 154 ? -78.208 48.198  -56.469  1.00 43.09  ? 1498 ASP A OD2 1 
ATOM   3637 N N   . ASN D 3 155 ? -74.350 45.494  -59.465  1.00 48.90  ? 1499 ASN A N   1 
ATOM   3638 C CA  . ASN D 3 155 ? -73.726 45.470  -60.783  1.00 42.64  ? 1499 ASN A CA  1 
ATOM   3639 C C   . ASN D 3 155 ? -72.612 44.435  -60.892  1.00 46.39  ? 1499 ASN A C   1 
ATOM   3640 O O   . ASN D 3 155 ? -71.803 44.504  -61.822  1.00 42.52  ? 1499 ASN A O   1 
ATOM   3641 C CB  . ASN D 3 155 ? -73.190 46.856  -61.137  1.00 31.28  ? 1499 ASN A CB  1 
ATOM   3642 C CG  . ASN D 3 155 ? -74.281 47.900  -61.188  1.00 41.97  ? 1499 ASN A CG  1 
ATOM   3643 O OD1 . ASN D 3 155 ? -75.135 47.885  -62.078  1.00 48.66  ? 1499 ASN A OD1 1 
ATOM   3644 N ND2 . ASN D 3 155 ? -74.265 48.813  -60.224  1.00 31.55  ? 1499 ASN A ND2 1 
ATOM   3645 N N   . CYS D 3 156 ? -72.543 43.482  -59.963  1.00 46.25  ? 1500 CYS A N   1 
ATOM   3646 C CA  . CYS D 3 156 ? -71.581 42.395  -60.110  1.00 34.64  ? 1500 CYS A CA  1 
ATOM   3647 C C   . CYS D 3 156 ? -71.930 41.521  -61.309  1.00 37.20  ? 1500 CYS A C   1 
ATOM   3648 O O   . CYS D 3 156 ? -71.061 41.199  -62.129  1.00 30.36  ? 1500 CYS A O   1 
ATOM   3649 C CB  . CYS D 3 156 ? -71.523 41.558  -58.832  1.00 52.20  ? 1500 CYS A CB  1 
ATOM   3650 S SG  . CYS D 3 156 ? -70.092 40.447  -58.733  1.00 61.04  ? 1500 CYS A SG  1 
ATOM   3651 N N   . GLU D 3 157 ? -73.206 41.142  -61.434  1.00 33.76  ? 1501 GLU A N   1 
ATOM   3652 C CA  . GLU D 3 157 ? -73.615 40.260  -62.524  1.00 26.84  ? 1501 GLU A CA  1 
ATOM   3653 C C   . GLU D 3 157 ? -73.363 40.898  -63.882  1.00 23.97  ? 1501 GLU A C   1 
ATOM   3654 O O   . GLU D 3 157 ? -73.009 40.206  -64.844  1.00 42.23  ? 1501 GLU A O   1 
ATOM   3655 C CB  . GLU D 3 157 ? -75.088 39.886  -62.378  1.00 30.95  ? 1501 GLU A CB  1 
ATOM   3656 C CG  . GLU D 3 157 ? -75.505 38.701  -63.240  1.00 26.98  ? 1501 GLU A CG  1 
ATOM   3657 C CD  . GLU D 3 157 ? -76.985 38.712  -63.579  1.00 41.52  ? 1501 GLU A CD  1 
ATOM   3658 O OE1 . GLU D 3 157 ? -77.766 39.337  -62.830  1.00 51.88  ? 1501 GLU A OE1 1 
ATOM   3659 O OE2 . GLU D 3 157 ? -77.368 38.091  -64.593  1.00 49.40  ? 1501 GLU A OE2 1 
ATOM   3660 N N   . LEU D 3 158 ? -73.543 42.216  -63.985  1.00 25.91  ? 1502 LEU A N   1 
ATOM   3661 C CA  . LEU D 3 158 ? -73.292 42.893  -65.253  1.00 33.40  ? 1502 LEU A CA  1 
ATOM   3662 C C   . LEU D 3 158 ? -71.829 42.774  -65.656  1.00 30.17  ? 1502 LEU A C   1 
ATOM   3663 O O   . LEU D 3 158 ? -71.510 42.364  -66.779  1.00 21.30  ? 1502 LEU A O   1 
ATOM   3664 C CB  . LEU D 3 158 ? -73.698 44.363  -65.156  1.00 31.92  ? 1502 LEU A CB  1 
ATOM   3665 C CG  . LEU D 3 158 ? -72.994 45.292  -66.149  1.00 21.56  ? 1502 LEU A CG  1 
ATOM   3666 C CD1 . LEU D 3 158 ? -73.456 45.010  -67.575  1.00 29.82  ? 1502 LEU A CD1 1 
ATOM   3667 C CD2 . LEU D 3 158 ? -73.204 46.752  -65.782  1.00 22.80  ? 1502 LEU A CD2 1 
ATOM   3668 N N   . ALA D 3 159 ? -70.922 43.118  -64.740  1.00 25.15  ? 1503 ALA A N   1 
ATOM   3669 C CA  . ALA D 3 159 ? -69.517 43.230  -65.108  1.00 19.18  ? 1503 ALA A CA  1 
ATOM   3670 C C   . ALA D 3 159 ? -68.882 41.869  -65.360  1.00 26.79  ? 1503 ALA A C   1 
ATOM   3671 O O   . ALA D 3 159 ? -67.947 41.769  -66.164  1.00 45.45  ? 1503 ALA A O   1 
ATOM   3672 C CB  . ALA D 3 159 ? -68.752 43.994  -64.031  1.00 16.90  ? 1503 ALA A CB  1 
ATOM   3673 N N   A CYS D 3 160 ? -69.356 40.814  -64.698  0.42 24.25  ? 1504 CYS A N   1 
ATOM   3674 N N   B CYS D 3 160 ? -69.374 40.816  -64.699  0.58 22.81  ? 1504 CYS A N   1 
ATOM   3675 C CA  A CYS D 3 160 ? -68.782 39.503  -64.976  0.42 22.42  ? 1504 CYS A CA  1 
ATOM   3676 C CA  B CYS D 3 160 ? -68.823 39.485  -64.934  0.58 23.06  ? 1504 CYS A CA  1 
ATOM   3677 C C   A CYS D 3 160 ? -69.214 38.990  -66.342  0.42 22.36  ? 1504 CYS A C   1 
ATOM   3678 C C   B CYS D 3 160 ? -69.230 38.958  -66.305  0.58 22.32  ? 1504 CYS A C   1 
ATOM   3679 O O   A CYS D 3 160 ? -68.406 38.403  -67.071  0.42 25.28  ? 1504 CYS A O   1 
ATOM   3680 O O   B CYS D 3 160 ? -68.418 38.342  -67.004  0.58 24.59  ? 1504 CYS A O   1 
ATOM   3681 C CB  A CYS D 3 160 ? -69.158 38.495  -63.899  0.42 23.74  ? 1504 CYS A CB  1 
ATOM   3682 C CB  B CYS D 3 160 ? -69.264 38.516  -63.835  0.58 23.64  ? 1504 CYS A CB  1 
ATOM   3683 S SG  A CYS D 3 160 ? -68.330 36.922  -64.188  0.42 23.50  ? 1504 CYS A SG  1 
ATOM   3684 S SG  B CYS D 3 160 ? -70.900 37.783  -64.075  0.58 36.49  ? 1504 CYS A SG  1 
ATOM   3685 N N   . CYS D 3 161 ? -70.484 39.193  -66.706  1.00 18.63  ? 1505 CYS A N   1 
ATOM   3686 C CA  . CYS D 3 161 ? -70.915 38.812  -68.047  1.00 20.50  ? 1505 CYS A CA  1 
ATOM   3687 C C   . CYS D 3 161 ? -70.085 39.520  -69.104  1.00 15.17  ? 1505 CYS A C   1 
ATOM   3688 O O   . CYS D 3 161 ? -69.858 38.972  -70.189  1.00 21.48  ? 1505 CYS A O   1 
ATOM   3689 C CB  . CYS D 3 161 ? -72.396 39.128  -68.249  1.00 19.90  ? 1505 CYS A CB  1 
ATOM   3690 S SG  . CYS D 3 161 ? -73.521 38.204  -67.192  1.00 51.65  ? 1505 CYS A SG  1 
ATOM   3691 N N   . PHE D 3 162 ? -69.617 40.732  -68.799  1.00 12.45  ? 1506 PHE A N   1 
ATOM   3692 C CA  . PHE D 3 162 ? -68.726 41.438  -69.710  1.00 22.46  ? 1506 PHE A CA  1 
ATOM   3693 C C   . PHE D 3 162 ? -67.401 40.703  -69.844  1.00 26.51  ? 1506 PHE A C   1 
ATOM   3694 O O   . PHE D 3 162 ? -66.918 40.463  -70.957  1.00 33.67  ? 1506 PHE A O   1 
ATOM   3695 C CB  . PHE D 3 162 ? -68.504 42.866  -69.216  1.00 36.16  ? 1506 PHE A CB  1 
ATOM   3696 C CG  . PHE D 3 162 ? -67.751 43.737  -70.182  1.00 42.01  ? 1506 PHE A CG  1 
ATOM   3697 C CD1 . PHE D 3 162 ? -68.424 44.451  -71.161  1.00 41.72  ? 1506 PHE A CD1 1 
ATOM   3698 C CD2 . PHE D 3 162 ? -66.371 43.848  -70.106  1.00 32.20  ? 1506 PHE A CD2 1 
ATOM   3699 C CE1 . PHE D 3 162 ? -67.733 45.259  -72.049  1.00 43.52  ? 1506 PHE A CE1 1 
ATOM   3700 C CE2 . PHE D 3 162 ? -65.674 44.652  -70.991  1.00 30.69  ? 1506 PHE A CE2 1 
ATOM   3701 C CZ  . PHE D 3 162 ? -66.357 45.358  -71.965  1.00 43.56  ? 1506 PHE A CZ  1 
ATOM   3702 N N   . ILE D 3 163 ? -66.796 40.336  -68.714  1.00 21.71  ? 1507 ILE A N   1 
ATOM   3703 C CA  . ILE D 3 163 ? -65.541 39.596  -68.768  1.00 32.21  ? 1507 ILE A CA  1 
ATOM   3704 C C   . ILE D 3 163 ? -65.774 38.201  -69.333  1.00 24.50  ? 1507 ILE A C   1 
ATOM   3705 O O   . ILE D 3 163 ? -64.960 37.687  -70.111  1.00 21.46  ? 1507 ILE A O   1 
ATOM   3706 C CB  . ILE D 3 163 ? -64.884 39.561  -67.378  1.00 23.47  ? 1507 ILE A CB  1 
ATOM   3707 C CG1 . ILE D 3 163 ? -64.284 40.930  -67.062  1.00 33.64  ? 1507 ILE A CG1 1 
ATOM   3708 C CG2 . ILE D 3 163 ? -63.803 38.498  -67.318  1.00 31.03  ? 1507 ILE A CG2 1 
ATOM   3709 C CD1 . ILE D 3 163 ? -64.037 41.176  -65.602  1.00 19.97  ? 1507 ILE A CD1 1 
ATOM   3710 N N   . GLN D 3 164 ? -66.898 37.579  -68.971  1.00 17.72  ? 1508 GLN A N   1 
ATOM   3711 C CA  . GLN D 3 164 ? -67.267 36.303  -69.572  1.00 19.33  ? 1508 GLN A CA  1 
ATOM   3712 C C   . GLN D 3 164 ? -67.300 36.405  -71.093  1.00 18.79  ? 1508 GLN A C   1 
ATOM   3713 O O   . GLN D 3 164 ? -66.675 35.602  -71.795  1.00 32.72  ? 1508 GLN A O   1 
ATOM   3714 C CB  . GLN D 3 164 ? -68.623 35.849  -69.034  1.00 19.34  ? 1508 GLN A CB  1 
ATOM   3715 C CG  . GLN D 3 164 ? -68.552 35.090  -67.725  1.00 17.10  ? 1508 GLN A CG  1 
ATOM   3716 C CD  . GLN D 3 164 ? -69.918 34.640  -67.248  1.00 21.13  ? 1508 GLN A CD  1 
ATOM   3717 O OE1 . GLN D 3 164 ? -70.347 33.523  -67.536  1.00 26.05  ? 1508 GLN A OE1 1 
ATOM   3718 N NE2 . GLN D 3 164 ? -70.604 35.503  -66.504  1.00 23.50  ? 1508 GLN A NE2 1 
ATOM   3719 N N   . LYS D 3 165 ? -68.011 37.405  -71.619  1.00 14.13  ? 1509 LYS A N   1 
ATOM   3720 C CA  . LYS D 3 165 ? -68.125 37.538  -73.067  1.00 19.10  ? 1509 LYS A CA  1 
ATOM   3721 C C   . LYS D 3 165 ? -66.784 37.860  -73.714  1.00 18.30  ? 1509 LYS A C   1 
ATOM   3722 O O   . LYS D 3 165 ? -66.538 37.456  -74.856  1.00 33.88  ? 1509 LYS A O   1 
ATOM   3723 C CB  . LYS D 3 165 ? -69.161 38.604  -73.416  1.00 23.33  ? 1509 LYS A CB  1 
ATOM   3724 C CG  . LYS D 3 165 ? -69.634 38.544  -74.857  1.00 27.84  ? 1509 LYS A CG  1 
ATOM   3725 C CD  . LYS D 3 165 ? -70.895 39.365  -75.079  1.00 26.17  ? 1509 LYS A CD  1 
ATOM   3726 C CE  . LYS D 3 165 ? -70.981 39.861  -76.513  1.00 39.26  ? 1509 LYS A CE  1 
ATOM   3727 N NZ  . LYS D 3 165 ? -72.387 40.122  -76.933  1.00 39.92  ? 1509 LYS A NZ  1 
ATOM   3728 N N   . THR D 3 166 ? -65.905 38.573  -73.008  1.00 19.46  ? 1510 THR A N   1 
ATOM   3729 C CA  . THR D 3 166 ? -64.571 38.829  -73.540  1.00 19.08  ? 1510 THR A CA  1 
ATOM   3730 C C   . THR D 3 166 ? -63.792 37.532  -73.685  1.00 27.92  ? 1510 THR A C   1 
ATOM   3731 O O   . THR D 3 166 ? -63.153 37.285  -74.715  1.00 33.57  ? 1510 THR A O   1 
ATOM   3732 C CB  . THR D 3 166 ? -63.816 39.795  -72.630  1.00 20.34  ? 1510 THR A CB  1 
ATOM   3733 O OG1 . THR D 3 166 ? -64.716 40.797  -72.144  1.00 31.37  ? 1510 THR A OG1 1 
ATOM   3734 C CG2 . THR D 3 166 ? -62.685 40.461  -73.395  1.00 22.17  ? 1510 THR A CG2 1 
ATOM   3735 N N   . ALA D 3 167 ? -63.833 36.689  -72.651  1.00 33.16  ? 1511 ALA A N   1 
ATOM   3736 C CA  . ALA D 3 167 ? -63.154 35.401  -72.719  1.00 32.19  ? 1511 ALA A CA  1 
ATOM   3737 C C   . ALA D 3 167 ? -63.752 34.518  -73.804  1.00 36.74  ? 1511 ALA A C   1 
ATOM   3738 O O   . ALA D 3 167 ? -63.017 33.875  -74.564  1.00 44.95  ? 1511 ALA A O   1 
ATOM   3739 C CB  . ALA D 3 167 ? -63.219 34.699  -71.363  1.00 18.66  ? 1511 ALA A CB  1 
ATOM   3740 N N   . VAL D 3 168 ? -65.083 34.478  -73.904  1.00 23.78  ? 1512 VAL A N   1 
ATOM   3741 C CA  . VAL D 3 168 ? -65.707 33.570  -74.861  1.00 21.72  ? 1512 VAL A CA  1 
ATOM   3742 C C   . VAL D 3 168 ? -65.342 33.965  -76.287  1.00 28.30  ? 1512 VAL A C   1 
ATOM   3743 O O   . VAL D 3 168 ? -65.225 33.106  -77.171  1.00 43.23  ? 1512 VAL A O   1 
ATOM   3744 C CB  . VAL D 3 168 ? -67.233 33.536  -74.646  1.00 16.12  ? 1512 VAL A CB  1 
ATOM   3745 C CG1 . VAL D 3 168 ? -67.911 32.815  -75.789  1.00 20.42  ? 1512 VAL A CG1 1 
ATOM   3746 C CG2 . VAL D 3 168 ? -67.577 32.890  -73.309  1.00 26.19  ? 1512 VAL A CG2 1 
ATOM   3747 N N   . GLU D 3 169 ? -65.133 35.260  -76.533  1.00 32.51  ? 1513 GLU A N   1 
ATOM   3748 C CA  . GLU D 3 169 ? -64.778 35.703  -77.875  1.00 35.33  ? 1513 GLU A CA  1 
ATOM   3749 C C   . GLU D 3 169 ? -63.297 35.505  -78.166  1.00 31.13  ? 1513 GLU A C   1 
ATOM   3750 O O   . GLU D 3 169 ? -62.926 35.251  -79.316  1.00 28.58  ? 1513 GLU A O   1 
ATOM   3751 C CB  . GLU D 3 169 ? -65.164 37.175  -78.069  1.00 40.82  ? 1513 GLU A CB  1 
ATOM   3752 C CG  . GLU D 3 169 ? -66.674 37.464  -78.078  1.00 40.13  ? 1513 GLU A CG  1 
ATOM   3753 C CD  . GLU D 3 169 ? -67.439 36.810  -79.228  1.00 48.58  ? 1513 GLU A CD  1 
ATOM   3754 O OE1 . GLU D 3 169 ? -68.645 37.101  -79.376  1.00 50.45  ? 1513 GLU A OE1 1 
ATOM   3755 O OE2 . GLU D 3 169 ? -66.845 36.021  -79.997  1.00 74.73  ? 1513 GLU A OE2 1 
ATOM   3756 N N   . LYS D 3 170 ? -62.442 35.625  -77.149  1.00 36.31  ? 1514 LYS A N   1 
ATOM   3757 C CA  . LYS D 3 170 ? -61.034 35.299  -77.335  1.00 37.68  ? 1514 LYS A CA  1 
ATOM   3758 C C   . LYS D 3 170 ? -60.820 33.790  -77.394  1.00 49.66  ? 1514 LYS A C   1 
ATOM   3759 O O   . LYS D 3 170 ? -59.868 33.322  -78.030  1.00 65.61  ? 1514 LYS A O   1 
ATOM   3760 C CB  . LYS D 3 170 ? -60.201 35.926  -76.212  1.00 35.38  ? 1514 LYS A CB  1 
ATOM   3761 C CG  . LYS D 3 170 ? -58.731 35.533  -76.205  1.00 37.41  ? 1514 LYS A CG  1 
ATOM   3762 C CD  . LYS D 3 170 ? -57.815 36.749  -76.222  1.00 41.92  ? 1514 LYS A CD  1 
ATOM   3763 C CE  . LYS D 3 170 ? -56.371 36.355  -75.927  1.00 58.08  ? 1514 LYS A CE  1 
ATOM   3764 N NZ  . LYS D 3 170 ? -55.374 37.225  -76.620  1.00 41.66  ? 1514 LYS A NZ  1 
ATOM   3765 N N   . ALA D 3 171 ? -61.710 33.014  -76.767  1.00 44.05  ? 1515 ALA A N   1 
ATOM   3766 C CA  . ALA D 3 171 ? -61.529 31.566  -76.714  1.00 35.72  ? 1515 ALA A CA  1 
ATOM   3767 C C   . ALA D 3 171 ? -61.741 30.910  -78.072  1.00 46.30  ? 1515 ALA A C   1 
ATOM   3768 O O   . ALA D 3 171 ? -61.134 29.870  -78.354  1.00 62.91  ? 1515 ALA A O   1 
ATOM   3769 C CB  . ALA D 3 171 ? -62.475 30.953  -75.683  1.00 58.17  ? 1515 ALA A CB  1 
ATOM   3770 N N   . GLY D 3 172 ? -62.592 31.485  -78.917  1.00 52.85  ? 1516 GLY A N   1 
ATOM   3771 C CA  . GLY D 3 172 ? -62.863 30.926  -80.220  1.00 54.58  ? 1516 GLY A CA  1 
ATOM   3772 C C   . GLY D 3 172 ? -61.620 30.802  -81.081  1.00 44.41  ? 1516 GLY A C   1 
ATOM   3773 O O   . GLY D 3 172 ? -61.173 29.698  -81.408  1.00 55.74  ? 1516 GLY A O   1 
ATOM   3774 N N   . PRO D 3 173 ? -61.050 31.945  -81.479  1.00 45.00  ? 1517 PRO A N   1 
ATOM   3775 C CA  . PRO D 3 173 ? -59.850 31.916  -82.334  1.00 49.64  ? 1517 PRO A CA  1 
ATOM   3776 C C   . PRO D 3 173 ? -58.729 31.030  -81.818  1.00 45.75  ? 1517 PRO A C   1 
ATOM   3777 O O   . PRO D 3 173 ? -58.058 30.367  -82.619  1.00 54.93  ? 1517 PRO A O   1 
ATOM   3778 C CB  . PRO D 3 173 ? -59.412 33.388  -82.374  1.00 57.90  ? 1517 PRO A CB  1 
ATOM   3779 C CG  . PRO D 3 173 ? -60.597 34.192  -81.931  1.00 64.62  ? 1517 PRO A CG  1 
ATOM   3780 C CD  . PRO D 3 173 ? -61.685 33.273  -81.458  1.00 61.23  ? 1517 PRO A CD  1 
ATOM   3781 N N   . GLU D 3 174 ? -58.501 30.994  -80.505  1.00 35.50  ? 1518 GLU A N   1 
ATOM   3782 C CA  . GLU D 3 174 ? -57.356 30.246  -80.004  1.00 56.48  ? 1518 GLU A CA  1 
ATOM   3783 C C   . GLU D 3 174 ? -57.620 28.740  -79.993  1.00 44.89  ? 1518 GLU A C   1 
ATOM   3784 O O   . GLU D 3 174 ? -56.681 27.950  -80.155  1.00 54.70  ? 1518 GLU A O   1 
ATOM   3785 C CB  . GLU D 3 174 ? -56.956 30.768  -78.616  1.00 43.27  ? 1518 GLU A CB  1 
ATOM   3786 C CG  . GLU D 3 174 ? -56.145 29.793  -77.787  1.00 51.05  ? 1518 GLU A CG  1 
ATOM   3787 C CD  . GLU D 3 174 ? -54.958 30.425  -77.078  1.00 82.36  ? 1518 GLU A CD  1 
ATOM   3788 O OE1 . GLU D 3 174 ? -53.960 29.704  -76.853  1.00 86.31  ? 1518 GLU A OE1 1 
ATOM   3789 O OE2 . GLU D 3 174 ? -55.020 31.620  -76.722  1.00 74.11  ? 1518 GLU A OE2 1 
ATOM   3790 N N   . MET D 3 175 ? -58.877 28.316  -79.829  1.00 37.90  ? 1519 MET A N   1 
ATOM   3791 C CA  . MET D 3 175 ? -59.187 26.901  -80.020  1.00 35.46  ? 1519 MET A CA  1 
ATOM   3792 C C   . MET D 3 175 ? -58.954 26.476  -81.460  1.00 35.71  ? 1519 MET A C   1 
ATOM   3793 O O   . MET D 3 175 ? -58.472 25.366  -81.718  1.00 42.28  ? 1519 MET A O   1 
ATOM   3794 C CB  . MET D 3 175 ? -60.625 26.591  -79.604  1.00 36.86  ? 1519 MET A CB  1 
ATOM   3795 C CG  . MET D 3 175 ? -61.083 25.233  -80.120  1.00 29.81  ? 1519 MET A CG  1 
ATOM   3796 S SD  . MET D 3 175 ? -61.111 23.924  -78.883  1.00 62.99  ? 1519 MET A SD  1 
ATOM   3797 C CE  . MET D 3 175 ? -62.517 24.387  -77.900  1.00 40.49  ? 1519 MET A CE  1 
ATOM   3798 N N   . ASP D 3 176 ? -59.295 27.344  -82.414  1.00 33.48  ? 1520 ASP A N   1 
ATOM   3799 C CA  . ASP D 3 176 ? -59.018 27.050  -83.814  1.00 31.14  ? 1520 ASP A CA  1 
ATOM   3800 C C   . ASP D 3 176 ? -57.544 26.747  -84.043  1.00 39.89  ? 1520 ASP A C   1 
ATOM   3801 O O   . ASP D 3 176 ? -57.205 25.956  -84.930  1.00 50.04  ? 1520 ASP A O   1 
ATOM   3802 C CB  . ASP D 3 176 ? -59.461 28.220  -84.688  1.00 47.10  ? 1520 ASP A CB  1 
ATOM   3803 C CG  . ASP D 3 176 ? -60.945 28.222  -84.933  1.00 40.57  ? 1520 ASP A CG  1 
ATOM   3804 O OD1 . ASP D 3 176 ? -61.576 27.168  -84.722  1.00 37.07  ? 1520 ASP A OD1 1 
ATOM   3805 O OD2 . ASP D 3 176 ? -61.483 29.270  -85.345  1.00 44.18  ? 1520 ASP A OD2 1 
ATOM   3806 N N   . LYS D 3 177 ? -56.655 27.364  -83.260  1.00 38.38  ? 1521 LYS A N   1 
ATOM   3807 C CA  . LYS D 3 177 ? -55.244 27.007  -83.342  1.00 38.02  ? 1521 LYS A CA  1 
ATOM   3808 C C   . LYS D 3 177 ? -55.025 25.579  -82.862  1.00 38.44  ? 1521 LYS A C   1 
ATOM   3809 O O   . LYS D 3 177 ? -54.393 24.769  -83.550  1.00 50.92  ? 1521 LYS A O   1 
ATOM   3810 C CB  . LYS D 3 177 ? -54.389 27.978  -82.522  1.00 37.33  ? 1521 LYS A CB  1 
ATOM   3811 C CG  . LYS D 3 177 ? -53.197 27.301  -81.831  1.00 47.48  ? 1521 LYS A CG  1 
ATOM   3812 C CD  . LYS D 3 177 ? -52.772 28.007  -80.557  1.00 53.05  ? 1521 LYS A CD  1 
ATOM   3813 C CE  . LYS D 3 177 ? -52.485 29.471  -80.807  1.00 47.56  ? 1521 LYS A CE  1 
ATOM   3814 N NZ  . LYS D 3 177 ? -52.005 30.151  -79.569  1.00 60.65  ? 1521 LYS A NZ  1 
ATOM   3815 N N   . ARG D 3 178 ? -55.554 25.247  -81.685  1.00 42.43  ? 1522 ARG A N   1 
ATOM   3816 C CA  . ARG D 3 178 ? -55.227 23.970  -81.070  1.00 43.08  ? 1522 ARG A CA  1 
ATOM   3817 C C   . ARG D 3 178 ? -55.941 22.804  -81.740  1.00 50.21  ? 1522 ARG A C   1 
ATOM   3818 O O   . ARG D 3 178 ? -55.525 21.653  -81.564  1.00 71.40  ? 1522 ARG A O   1 
ATOM   3819 C CB  . ARG D 3 178 ? -55.553 24.017  -79.575  1.00 38.79  ? 1522 ARG A CB  1 
ATOM   3820 C CG  . ARG D 3 178 ? -54.915 22.896  -78.770  1.00 41.62  ? 1522 ARG A CG  1 
ATOM   3821 C CD  . ARG D 3 178 ? -54.640 23.267  -77.309  1.00 45.86  ? 1522 ARG A CD  1 
ATOM   3822 N NE  . ARG D 3 178 ? -54.427 24.691  -77.060  1.00 69.67  ? 1522 ARG A NE  1 
ATOM   3823 C CZ  . ARG D 3 178 ? -53.441 25.427  -77.563  1.00 78.37  ? 1522 ARG A CZ  1 
ATOM   3824 N NH1 . ARG D 3 178 ? -52.527 24.910  -78.370  1.00 75.32  ? 1522 ARG A NH1 1 
ATOM   3825 N NH2 . ARG D 3 178 ? -53.371 26.717  -77.248  1.00 65.44  ? 1522 ARG A NH2 1 
ATOM   3826 N N   . LEU D 3 179 ? -56.988 23.072  -82.518  1.00 46.17  ? 1523 LEU A N   1 
ATOM   3827 C CA  . LEU D 3 179 ? -57.685 22.040  -83.269  1.00 38.33  ? 1523 LEU A CA  1 
ATOM   3828 C C   . LEU D 3 179 ? -57.297 22.028  -84.740  1.00 45.58  ? 1523 LEU A C   1 
ATOM   3829 O O   . LEU D 3 179 ? -57.917 21.307  -85.528  1.00 58.88  ? 1523 LEU A O   1 
ATOM   3830 C CB  . LEU D 3 179 ? -59.198 22.220  -83.131  1.00 22.46  ? 1523 LEU A CB  1 
ATOM   3831 C CG  . LEU D 3 179 ? -59.791 21.665  -81.835  1.00 26.04  ? 1523 LEU A CG  1 
ATOM   3832 C CD1 . LEU D 3 179 ? -61.281 21.439  -81.982  1.00 42.29  ? 1523 LEU A CD1 1 
ATOM   3833 C CD2 . LEU D 3 179 ? -59.095 20.376  -81.434  1.00 34.32  ? 1523 LEU A CD2 1 
ATOM   3834 N N   . ALA D 3 180 ? -56.282 22.805  -85.124  1.00 49.01  ? 1524 ALA A N   1 
ATOM   3835 C CA  . ALA D 3 180 ? -55.937 22.923  -86.537  1.00 52.75  ? 1524 ALA A CA  1 
ATOM   3836 C C   . ALA D 3 180 ? -55.429 21.602  -87.095  1.00 52.53  ? 1524 ALA A C   1 
ATOM   3837 O O   . ALA D 3 180 ? -55.729 21.250  -88.243  1.00 54.62  ? 1524 ALA A O   1 
ATOM   3838 C CB  . ALA D 3 180 ? -54.895 24.024  -86.732  1.00 64.12  ? 1524 ALA A CB  1 
ATOM   3839 N N   . THR D 3 181 ? -54.661 20.857  -86.297  1.00 53.77  ? 1525 THR A N   1 
ATOM   3840 C CA  . THR D 3 181 ? -54.113 19.587  -86.764  1.00 38.81  ? 1525 THR A CA  1 
ATOM   3841 C C   . THR D 3 181 ? -55.225 18.624  -87.160  1.00 50.52  ? 1525 THR A C   1 
ATOM   3842 O O   . THR D 3 181 ? -55.198 18.036  -88.248  1.00 64.73  ? 1525 THR A O   1 
ATOM   3843 C CB  . THR D 3 181 ? -53.227 18.968  -85.682  1.00 49.21  ? 1525 THR A CB  1 
ATOM   3844 O OG1 . THR D 3 181 ? -53.959 18.890  -84.451  1.00 68.50  ? 1525 THR A OG1 1 
ATOM   3845 C CG2 . THR D 3 181 ? -51.973 19.809  -85.470  1.00 55.89  ? 1525 THR A CG2 1 
ATOM   3846 N N   . GLU D 3 182 ? -56.224 18.462  -86.290  1.00 51.08  ? 1526 GLU A N   1 
ATOM   3847 C CA  . GLU D 3 182 ? -57.317 17.544  -86.584  1.00 42.97  ? 1526 GLU A CA  1 
ATOM   3848 C C   . GLU D 3 182 ? -58.146 18.016  -87.770  1.00 50.10  ? 1526 GLU A C   1 
ATOM   3849 O O   . GLU D 3 182 ? -58.639 17.188  -88.544  1.00 61.04  ? 1526 GLU A O   1 
ATOM   3850 C CB  . GLU D 3 182 ? -58.198 17.367  -85.352  1.00 35.99  ? 1526 GLU A CB  1 
ATOM   3851 C CG  . GLU D 3 182 ? -57.454 16.852  -84.132  1.00 55.08  ? 1526 GLU A CG  1 
ATOM   3852 C CD  . GLU D 3 182 ? -57.300 15.343  -84.139  1.00 69.95  ? 1526 GLU A CD  1 
ATOM   3853 O OE1 . GLU D 3 182 ? -58.136 14.658  -84.767  1.00 61.66  ? 1526 GLU A OE1 1 
ATOM   3854 O OE2 . GLU D 3 182 ? -56.338 14.843  -83.516  1.00 73.28  ? 1526 GLU A OE2 1 
ATOM   3855 N N   . PHE D 3 183 ? -58.307 19.333  -87.932  1.00 53.68  ? 1527 PHE A N   1 
ATOM   3856 C CA  . PHE D 3 183 ? -59.037 19.849  -89.086  1.00 51.73  ? 1527 PHE A CA  1 
ATOM   3857 C C   . PHE D 3 183 ? -58.359 19.463  -90.393  1.00 55.80  ? 1527 PHE A C   1 
ATOM   3858 O O   . PHE D 3 183 ? -59.040 19.225  -91.398  1.00 54.23  ? 1527 PHE A O   1 
ATOM   3859 C CB  . PHE D 3 183 ? -59.166 21.369  -88.997  1.00 56.52  ? 1527 PHE A CB  1 
ATOM   3860 C CG  . PHE D 3 183 ? -60.092 21.840  -87.913  1.00 57.89  ? 1527 PHE A CG  1 
ATOM   3861 C CD1 . PHE D 3 183 ? -61.203 21.092  -87.559  1.00 51.32  ? 1527 PHE A CD1 1 
ATOM   3862 C CD2 . PHE D 3 183 ? -59.856 23.036  -87.255  1.00 49.27  ? 1527 PHE A CD2 1 
ATOM   3863 C CE1 . PHE D 3 183 ? -62.057 21.526  -86.562  1.00 52.64  ? 1527 PHE A CE1 1 
ATOM   3864 C CE2 . PHE D 3 183 ? -60.708 23.476  -86.259  1.00 43.22  ? 1527 PHE A CE2 1 
ATOM   3865 C CZ  . PHE D 3 183 ? -61.808 22.720  -85.912  1.00 46.01  ? 1527 PHE A CZ  1 
ATOM   3866 N N   . GLU D 3 184 ? -57.025 19.394  -90.399  1.00 58.22  ? 1528 GLU A N   1 
ATOM   3867 C CA  . GLU D 3 184 ? -56.302 19.055  -91.620  1.00 70.02  ? 1528 GLU A CA  1 
ATOM   3868 C C   . GLU D 3 184 ? -56.532 17.602  -92.015  1.00 64.49  ? 1528 GLU A C   1 
ATOM   3869 O O   . GLU D 3 184 ? -56.721 17.298  -93.199  1.00 54.83  ? 1528 GLU A O   1 
ATOM   3870 C CB  . GLU D 3 184 ? -54.808 19.328  -91.436  1.00 66.87  ? 1528 GLU A CB  1 
ATOM   3871 C CG  . GLU D 3 184 ? -54.247 20.419  -92.341  1.00 82.16  ? 1528 GLU A CG  1 
ATOM   3872 C CD  . GLU D 3 184 ? -54.375 20.089  -93.819  1.00 107.00 ? 1528 GLU A CD  1 
ATOM   3873 O OE1 . GLU D 3 184 ? -53.548 19.304  -94.331  1.00 106.46 ? 1528 GLU A OE1 1 
ATOM   3874 O OE2 . GLU D 3 184 ? -55.299 20.619  -94.471  1.00 102.82 ? 1528 GLU A OE2 1 
ATOM   3875 N N   . LEU D 3 185 ? -56.525 16.694  -91.037  1.00 50.57  ? 1529 LEU A N   1 
ATOM   3876 C CA  . LEU D 3 185 ? -56.632 15.272  -91.344  1.00 47.85  ? 1529 LEU A CA  1 
ATOM   3877 C C   . LEU D 3 185 ? -57.973 14.927  -91.978  1.00 51.13  ? 1529 LEU A C   1 
ATOM   3878 O O   . LEU D 3 185 ? -58.042 14.036  -92.833  1.00 62.53  ? 1529 LEU A O   1 
ATOM   3879 C CB  . LEU D 3 185 ? -56.414 14.447  -90.076  1.00 43.11  ? 1529 LEU A CB  1 
ATOM   3880 C CG  . LEU D 3 185 ? -55.214 14.815  -89.196  1.00 44.11  ? 1529 LEU A CG  1 
ATOM   3881 C CD1 . LEU D 3 185 ? -54.970 13.738  -88.150  1.00 32.29  ? 1529 LEU A CD1 1 
ATOM   3882 C CD2 . LEU D 3 185 ? -53.956 15.050  -90.025  1.00 42.05  ? 1529 LEU A CD2 1 
ATOM   3883 N N   . ARG D 3 186 ? -59.041 15.622  -91.588  1.00 45.61  ? 1530 ARG A N   1 
ATOM   3884 C CA  . ARG D 3 186 ? -60.367 15.312  -92.107  1.00 61.98  ? 1530 ARG A CA  1 
ATOM   3885 C C   . ARG D 3 186 ? -60.603 15.883  -93.498  1.00 66.68  ? 1530 ARG A C   1 
ATOM   3886 O O   . ARG D 3 186 ? -61.469 15.376  -94.221  1.00 64.75  ? 1530 ARG A O   1 
ATOM   3887 C CB  . ARG D 3 186 ? -61.431 15.821  -91.135  1.00 57.61  ? 1530 ARG A CB  1 
ATOM   3888 C CG  . ARG D 3 186 ? -61.117 15.444  -89.703  1.00 43.00  ? 1530 ARG A CG  1 
ATOM   3889 C CD  . ARG D 3 186 ? -62.341 15.454  -88.806  1.00 37.42  ? 1530 ARG A CD  1 
ATOM   3890 N NE  . ARG D 3 186 ? -62.250 14.456  -87.743  1.00 45.82  ? 1530 ARG A NE  1 
ATOM   3891 C CZ  . ARG D 3 186 ? -61.333 14.441  -86.782  1.00 46.77  ? 1530 ARG A CZ  1 
ATOM   3892 N NH1 . ARG D 3 186 ? -60.407 15.383  -86.689  1.00 44.40  ? 1530 ARG A NH1 1 
ATOM   3893 N NH2 . ARG D 3 186 ? -61.350 13.460  -85.884  1.00 45.01  ? 1530 ARG A NH2 1 
ATOM   3894 N N   . LYS D 3 187 ? -59.858 16.915  -93.891  1.00 58.23  ? 1531 LYS A N   1 
ATOM   3895 C CA  . LYS D 3 187 ? -59.933 17.409  -95.259  1.00 64.53  ? 1531 LYS A CA  1 
ATOM   3896 C C   . LYS D 3 187 ? -58.874 16.782  -96.157  1.00 67.64  ? 1531 LYS A C   1 
ATOM   3897 O O   . LYS D 3 187 ? -59.098 16.659  -97.367  1.00 67.91  ? 1531 LYS A O   1 
ATOM   3898 C CB  . LYS D 3 187 ? -59.806 18.935  -95.283  1.00 70.44  ? 1531 LYS A CB  1 
ATOM   3899 C CG  . LYS D 3 187 ? -58.569 19.475  -94.590  1.00 81.00  ? 1531 LYS A CG  1 
ATOM   3900 C CD  . LYS D 3 187 ? -58.446 20.980  -94.770  1.00 88.68  ? 1531 LYS A CD  1 
ATOM   3901 C CE  . LYS D 3 187 ? -59.306 21.730  -93.766  1.00 79.24  ? 1531 LYS A CE  1 
ATOM   3902 N NZ  . LYS D 3 187 ? -58.550 22.835  -93.112  1.00 70.23  ? 1531 LYS A NZ  1 
ATOM   3903 N N   . HIS D 3 188 ? -57.728 16.386  -95.592  1.00 68.69  ? 1532 HIS A N   1 
ATOM   3904 C CA  . HIS D 3 188 ? -56.751 15.605  -96.349  1.00 59.33  ? 1532 HIS A CA  1 
ATOM   3905 C C   . HIS D 3 188 ? -57.375 14.301  -96.826  1.00 64.05  ? 1532 HIS A C   1 
ATOM   3906 O O   . HIS D 3 188 ? -57.308 13.964  -98.015  1.00 78.52  ? 1532 HIS A O   1 
ATOM   3907 C CB  . HIS D 3 188 ? -55.512 15.346  -95.481  1.00 45.24  ? 1532 HIS A CB  1 
ATOM   3908 C CG  . HIS D 3 188 ? -54.547 14.332  -96.034  1.00 69.00  ? 1532 HIS A CG  1 
ATOM   3909 N ND1 . HIS D 3 188 ? -53.372 14.013  -95.388  1.00 98.23  ? 1532 HIS A ND1 1 
ATOM   3910 C CD2 . HIS D 3 188 ? -54.557 13.593  -97.170  1.00 88.25  ? 1532 HIS A CD2 1 
ATOM   3911 C CE1 . HIS D 3 188 ? -52.714 13.107  -96.088  1.00 85.18  ? 1532 HIS A CE1 1 
ATOM   3912 N NE2 . HIS D 3 188 ? -53.413 12.833  -97.174  1.00 88.95  ? 1532 HIS A NE2 1 
ATOM   3913 N N   . ALA D 3 189 ? -57.986 13.552  -95.907  1.00 58.58  ? 1533 ALA A N   1 
ATOM   3914 C CA  . ALA D 3 189 ? -58.650 12.312  -96.287  1.00 60.25  ? 1533 ALA A CA  1 
ATOM   3915 C C   . ALA D 3 189 ? -59.694 12.546  -97.373  1.00 59.37  ? 1533 ALA A C   1 
ATOM   3916 O O   . ALA D 3 189 ? -59.887 11.688  -98.242  1.00 76.88  ? 1533 ALA A O   1 
ATOM   3917 C CB  . ALA D 3 189 ? -59.286 11.660  -95.059  1.00 69.07  ? 1533 ALA A CB  1 
ATOM   3918 N N   . ARG D 3 190 ? -60.361 13.704  -97.354  1.00 55.24  ? 1534 ARG A N   1 
ATOM   3919 C CA  . ARG D 3 190 ? -61.285 14.043  -98.432  1.00 64.97  ? 1534 ARG A CA  1 
ATOM   3920 C C   . ARG D 3 190 ? -60.547 14.238  -99.752  1.00 70.86  ? 1534 ARG A C   1 
ATOM   3921 O O   . ARG D 3 190 ? -61.060 13.872  -100.817 1.00 59.00  ? 1534 ARG A O   1 
ATOM   3922 C CB  . ARG D 3 190 ? -62.077 15.299  -98.072  1.00 66.17  ? 1534 ARG A CB  1 
ATOM   3923 C CG  . ARG D 3 190 ? -63.545 15.049  -97.786  1.00 62.66  ? 1534 ARG A CG  1 
ATOM   3924 C CD  . ARG D 3 190 ? -64.302 16.358  -97.645  1.00 63.28  ? 1534 ARG A CD  1 
ATOM   3925 N NE  . ARG D 3 190 ? -64.346 16.816  -96.262  1.00 75.19  ? 1534 ARG A NE  1 
ATOM   3926 C CZ  . ARG D 3 190 ? -65.351 17.500  -95.732  1.00 86.67  ? 1534 ARG A CZ  1 
ATOM   3927 N NH1 . ARG D 3 190 ? -66.417 17.827  -96.446  1.00 75.59  ? 1534 ARG A NH1 1 
ATOM   3928 N NH2 . ARG D 3 190 ? -65.287 17.864  -94.454  1.00 81.67  ? 1534 ARG A NH2 1 
ATOM   3929 N N   . GLN D 3 191 ? -59.344 14.821  -99.700  1.00 84.31  ? 1535 GLN A N   1 
ATOM   3930 C CA  . GLN D 3 191 ? -58.533 14.966  -100.905 1.00 86.91  ? 1535 GLN A CA  1 
ATOM   3931 C C   . GLN D 3 191 ? -58.105 13.612  -101.453 1.00 86.05  ? 1535 GLN A C   1 
ATOM   3932 O O   . GLN D 3 191 ? -57.901 13.468  -102.664 1.00 95.78  ? 1535 GLN A O   1 
ATOM   3933 C CB  . GLN D 3 191 ? -57.303 15.830  -100.613 1.00 65.19  ? 1535 GLN A CB  1 
ATOM   3934 C CG  . GLN D 3 191 ? -57.600 17.314  -100.452 1.00 59.13  ? 1535 GLN A CG  1 
ATOM   3935 C CD  . GLN D 3 191 ? -56.572 18.025  -99.588  1.00 77.61  ? 1535 GLN A CD  1 
ATOM   3936 O OE1 . GLN D 3 191 ? -55.498 17.489  -99.308  1.00 76.45  ? 1535 GLN A OE1 1 
ATOM   3937 N NE2 . GLN D 3 191 ? -56.898 19.241  -99.162  1.00 67.07  ? 1535 GLN A NE2 1 
ATOM   3938 N N   . GLU D 3 192 ? -57.963 12.615  -100.583 1.00 72.93  ? 1536 GLU A N   1 
ATOM   3939 C CA  . GLU D 3 192 ? -57.631 11.258  -100.990 1.00 59.97  ? 1536 GLU A CA  1 
ATOM   3940 C C   . GLU D 3 192 ? -58.865 10.373  -101.128 1.00 58.49  ? 1536 GLU A C   1 
ATOM   3941 O O   . GLU D 3 192 ? -58.729 9.149   -101.219 1.00 64.01  ? 1536 GLU A O   1 
ATOM   3942 C CB  . GLU D 3 192 ? -56.645 10.642  -99.996  1.00 69.03  ? 1536 GLU A CB  1 
ATOM   3943 C CG  . GLU D 3 192 ? -55.362 11.443  -99.830  1.00 74.00  ? 1536 GLU A CG  1 
ATOM   3944 C CD  . GLU D 3 192 ? -54.246 10.953  -100.734 1.00 101.92 ? 1536 GLU A CD  1 
ATOM   3945 O OE1 . GLU D 3 192 ? -53.565 9.974   -100.361 1.00 102.61 ? 1536 GLU A OE1 1 
ATOM   3946 O OE2 . GLU D 3 192 ? -54.049 11.549  -101.815 1.00 111.60 ? 1536 GLU A OE2 1 
ATOM   3947 N N   . GLY D 3 193 ? -60.061 10.963  -101.137 1.00 61.20  ? 1537 GLY A N   1 
ATOM   3948 C CA  . GLY D 3 193 ? -61.285 10.218  -101.366 1.00 73.00  ? 1537 GLY A CA  1 
ATOM   3949 C C   . GLY D 3 193 ? -61.654 9.210   -100.300 1.00 64.97  ? 1537 GLY A C   1 
ATOM   3950 O O   . GLY D 3 193 ? -62.364 8.244   -100.596 1.00 54.75  ? 1537 GLY A O   1 
ATOM   3951 N N   . ARG D 3 194 ? -61.202 9.407   -99.064  1.00 59.53  ? 1538 ARG A N   1 
ATOM   3952 C CA  . ARG D 3 194 ? -61.465 8.477   -97.977  1.00 62.28  ? 1538 ARG A CA  1 
ATOM   3953 C C   . ARG D 3 194 ? -61.992 9.231   -96.764  1.00 57.60  ? 1538 ARG A C   1 
ATOM   3954 O O   . ARG D 3 194 ? -61.785 10.437  -96.615  1.00 61.89  ? 1538 ARG A O   1 
ATOM   3955 C CB  . ARG D 3 194 ? -60.200 7.695   -97.587  1.00 57.24  ? 1538 ARG A CB  1 
ATOM   3956 C CG  . ARG D 3 194 ? -59.092 8.576   -97.032  1.00 49.63  ? 1538 ARG A CG  1 
ATOM   3957 C CD  . ARG D 3 194 ? -57.732 7.912   -97.126  1.00 45.62  ? 1538 ARG A CD  1 
ATOM   3958 N NE  . ARG D 3 194 ? -56.994 8.046   -95.876  1.00 70.79  ? 1538 ARG A NE  1 
ATOM   3959 C CZ  . ARG D 3 194 ? -55.827 8.665   -95.757  1.00 86.81  ? 1538 ARG A CZ  1 
ATOM   3960 N NH1 . ARG D 3 194 ? -55.225 9.211   -96.802  1.00 86.05  ? 1538 ARG A NH1 1 
ATOM   3961 N NH2 . ARG D 3 194 ? -55.252 8.740   -94.561  1.00 74.89  ? 1538 ARG A NH2 1 
ATOM   3962 N N   . ARG D 3 195 ? -62.690 8.507   -95.894  1.00 46.27  ? 1539 ARG A N   1 
ATOM   3963 C CA  . ARG D 3 195 ? -63.061 9.078   -94.612  1.00 40.30  ? 1539 ARG A CA  1 
ATOM   3964 C C   . ARG D 3 195 ? -61.845 9.133   -93.696  1.00 48.59  ? 1539 ARG A C   1 
ATOM   3965 O O   . ARG D 3 195 ? -60.873 8.389   -93.863  1.00 46.19  ? 1539 ARG A O   1 
ATOM   3966 C CB  . ARG D 3 195 ? -64.158 8.258   -93.936  1.00 42.88  ? 1539 ARG A CB  1 
ATOM   3967 C CG  . ARG D 3 195 ? -65.469 8.180   -94.686  1.00 51.15  ? 1539 ARG A CG  1 
ATOM   3968 C CD  . ARG D 3 195 ? -66.354 7.128   -94.044  1.00 34.72  ? 1539 ARG A CD  1 
ATOM   3969 N NE  . ARG D 3 195 ? -67.097 6.353   -95.027  1.00 59.29  ? 1539 ARG A NE  1 
ATOM   3970 C CZ  . ARG D 3 195 ? -67.806 5.270   -94.742  1.00 66.13  ? 1539 ARG A CZ  1 
ATOM   3971 N NH1 . ARG D 3 195 ? -67.848 4.776   -93.515  1.00 70.47  ? 1539 ARG A NH1 1 
ATOM   3972 N NH2 . ARG D 3 195 ? -68.489 4.668   -95.710  1.00 57.85  ? 1539 ARG A NH2 1 
ATOM   3973 N N   . TYR D 3 196 ? -61.903 10.027  -92.717  1.00 48.64  ? 1540 TYR A N   1 
ATOM   3974 C CA  . TYR D 3 196 ? -60.905 10.035  -91.663  1.00 35.95  ? 1540 TYR A CA  1 
ATOM   3975 C C   . TYR D 3 196 ? -61.394 9.199   -90.492  1.00 48.35  ? 1540 TYR A C   1 
ATOM   3976 O O   . TYR D 3 196 ? -62.559 9.287   -90.090  1.00 32.82  ? 1540 TYR A O   1 
ATOM   3977 C CB  . TYR D 3 196 ? -60.586 11.446  -91.178  1.00 39.03  ? 1540 TYR A CB  1 
ATOM   3978 C CG  . TYR D 3 196 ? -59.643 11.433  -89.993  1.00 34.58  ? 1540 TYR A CG  1 
ATOM   3979 C CD1 . TYR D 3 196 ? -58.332 10.998  -90.131  1.00 37.20  ? 1540 TYR A CD1 1 
ATOM   3980 C CD2 . TYR D 3 196 ? -60.071 11.827  -88.733  1.00 37.35  ? 1540 TYR A CD2 1 
ATOM   3981 C CE1 . TYR D 3 196 ? -57.466 10.974  -89.050  1.00 37.25  ? 1540 TYR A CE1 1 
ATOM   3982 C CE2 . TYR D 3 196 ? -59.213 11.808  -87.645  1.00 41.82  ? 1540 TYR A CE2 1 
ATOM   3983 C CZ  . TYR D 3 196 ? -57.912 11.380  -87.810  1.00 38.24  ? 1540 TYR A CZ  1 
ATOM   3984 O OH  . TYR D 3 196 ? -57.057 11.357  -86.730  1.00 42.77  ? 1540 TYR A OH  1 
ATOM   3985 N N   . CYS D 3 197 ? -60.488 8.385   -89.956  1.00 49.57  ? 1541 CYS A N   1 
ATOM   3986 C CA  . CYS D 3 197 ? -60.771 7.537   -88.806  1.00 31.89  ? 1541 CYS A CA  1 
ATOM   3987 C C   . CYS D 3 197 ? -59.478 7.376   -88.027  1.00 35.65  ? 1541 CYS A C   1 
ATOM   3988 O O   . CYS D 3 197 ? -58.495 6.866   -88.573  1.00 53.03  ? 1541 CYS A O   1 
ATOM   3989 C CB  . CYS D 3 197 ? -61.312 6.176   -89.245  1.00 21.76  ? 1541 CYS A CB  1 
ATOM   3990 S SG  . CYS D 3 197 ? -62.973 6.243   -89.950  1.00 57.47  ? 1541 CYS A SG  1 
ATOM   3991 N N   . ASP D 3 198 ? -59.474 7.822   -86.774  1.00 25.19  ? 1542 ASP A N   1 
ATOM   3992 C CA  . ASP D 3 198 ? -58.289 7.706   -85.935  1.00 31.00  ? 1542 ASP A CA  1 
ATOM   3993 C C   . ASP D 3 198 ? -57.916 6.236   -85.794  1.00 37.91  ? 1542 ASP A C   1 
ATOM   3994 O O   . ASP D 3 198 ? -58.731 5.443   -85.294  1.00 43.40  ? 1542 ASP A O   1 
ATOM   3995 C CB  . ASP D 3 198 ? -58.524 8.328   -84.559  1.00 31.81  ? 1542 ASP A CB  1 
ATOM   3996 C CG  . ASP D 3 198 ? -57.271 8.319   -83.687  1.00 39.47  ? 1542 ASP A CG  1 
ATOM   3997 O OD1 . ASP D 3 198 ? -56.150 8.237   -84.237  1.00 36.20  ? 1542 ASP A OD1 1 
ATOM   3998 O OD2 . ASP D 3 198 ? -57.409 8.391   -82.447  1.00 33.14  ? 1542 ASP A OD2 1 
ATOM   3999 N N   . PRO D 3 199 ? -56.721 5.827   -86.230  1.00 30.19  ? 1543 PRO A N   1 
ATOM   4000 C CA  . PRO D 3 199 ? -56.367 4.398   -86.169  1.00 40.55  ? 1543 PRO A CA  1 
ATOM   4001 C C   . PRO D 3 199 ? -56.459 3.805   -84.775  1.00 48.75  ? 1543 PRO A C   1 
ATOM   4002 O O   . PRO D 3 199 ? -56.831 2.634   -84.626  1.00 50.10  ? 1543 PRO A O   1 
ATOM   4003 C CB  . PRO D 3 199 ? -54.926 4.381   -86.695  1.00 46.92  ? 1543 PRO A CB  1 
ATOM   4004 C CG  . PRO D 3 199 ? -54.836 5.586   -87.571  1.00 46.66  ? 1543 PRO A CG  1 
ATOM   4005 C CD  . PRO D 3 199 ? -55.697 6.628   -86.921  1.00 24.40  ? 1543 PRO A CD  1 
ATOM   4006 N N   . VAL D 3 200 ? -56.135 4.584   -83.743  1.00 35.92  ? 1544 VAL A N   1 
ATOM   4007 C CA  . VAL D 3 200 ? -56.149 4.043   -82.391  1.00 23.54  ? 1544 VAL A CA  1 
ATOM   4008 C C   . VAL D 3 200 ? -57.576 3.906   -81.879  1.00 26.77  ? 1544 VAL A C   1 
ATOM   4009 O O   . VAL D 3 200 ? -57.935 2.887   -81.279  1.00 26.67  ? 1544 VAL A O   1 
ATOM   4010 C CB  . VAL D 3 200 ? -55.293 4.921   -81.463  1.00 18.32  ? 1544 VAL A CB  1 
ATOM   4011 C CG1 . VAL D 3 200 ? -55.019 4.197   -80.162  1.00 8.64   ? 1544 VAL A CG1 1 
ATOM   4012 C CG2 . VAL D 3 200 ? -53.994 5.301   -82.155  1.00 21.77  ? 1544 VAL A CG2 1 
ATOM   4013 N N   . VAL D 3 201 ? -58.413 4.919   -82.112  1.00 26.73  ? 1545 VAL A N   1 
ATOM   4014 C CA  . VAL D 3 201 ? -59.783 4.870   -81.611  1.00 29.74  ? 1545 VAL A CA  1 
ATOM   4015 C C   . VAL D 3 201 ? -60.596 3.836   -82.380  1.00 27.85  ? 1545 VAL A C   1 
ATOM   4016 O O   . VAL D 3 201 ? -61.349 3.053   -81.786  1.00 26.88  ? 1545 VAL A O   1 
ATOM   4017 C CB  . VAL D 3 201 ? -60.423 6.269   -81.679  1.00 28.10  ? 1545 VAL A CB  1 
ATOM   4018 C CG1 . VAL D 3 201 ? -61.934 6.165   -81.839  1.00 38.07  ? 1545 VAL A CG1 1 
ATOM   4019 C CG2 . VAL D 3 201 ? -60.073 7.061   -80.439  1.00 38.30  ? 1545 VAL A CG2 1 
ATOM   4020 N N   . LEU D 3 202 ? -60.448 3.807   -83.707  1.00 27.09  ? 1546 LEU A N   1 
ATOM   4021 C CA  . LEU D 3 202 ? -61.165 2.825   -84.513  1.00 37.37  ? 1546 LEU A CA  1 
ATOM   4022 C C   . LEU D 3 202 ? -60.846 1.402   -84.070  1.00 38.41  ? 1546 LEU A C   1 
ATOM   4023 O O   . LEU D 3 202 ? -61.706 0.517   -84.150  1.00 36.49  ? 1546 LEU A O   1 
ATOM   4024 C CB  . LEU D 3 202 ? -60.831 3.025   -85.993  1.00 18.32  ? 1546 LEU A CB  1 
ATOM   4025 C CG  . LEU D 3 202 ? -61.265 1.941   -86.979  1.00 28.57  ? 1546 LEU A CG  1 
ATOM   4026 C CD1 . LEU D 3 202 ? -62.650 2.240   -87.527  1.00 35.93  ? 1546 LEU A CD1 1 
ATOM   4027 C CD2 . LEU D 3 202 ? -60.256 1.825   -88.111  1.00 30.93  ? 1546 LEU A CD2 1 
ATOM   4028 N N   . THR D 3 203 ? -59.628 1.170   -83.580  1.00 30.72  ? 1547 THR A N   1 
ATOM   4029 C CA  . THR D 3 203 ? -59.279 -0.142  -83.049  1.00 22.75  ? 1547 THR A CA  1 
ATOM   4030 C C   . THR D 3 203 ? -59.994 -0.411  -81.729  1.00 33.96  ? 1547 THR A C   1 
ATOM   4031 O O   . THR D 3 203 ? -60.655 -1.444  -81.573  1.00 37.90  ? 1547 THR A O   1 
ATOM   4032 C CB  . THR D 3 203 ? -57.763 -0.248  -82.876  1.00 28.77  ? 1547 THR A CB  1 
ATOM   4033 O OG1 . THR D 3 203 ? -57.112 0.207   -84.070  1.00 27.01  ? 1547 THR A OG1 1 
ATOM   4034 C CG2 . THR D 3 203 ? -57.354 -1.685  -82.591  1.00 35.32  ? 1547 THR A CG2 1 
ATOM   4035 N N   . TYR D 3 204 ? -59.877 0.512   -80.768  1.00 27.89  ? 1548 TYR A N   1 
ATOM   4036 C CA  . TYR D 3 204 ? -60.445 0.284   -79.440  1.00 24.59  ? 1548 TYR A CA  1 
ATOM   4037 C C   . TYR D 3 204 ? -61.950 0.062   -79.513  1.00 31.25  ? 1548 TYR A C   1 
ATOM   4038 O O   . TYR D 3 204 ? -62.478 -0.876  -78.904  1.00 44.29  ? 1548 TYR A O   1 
ATOM   4039 C CB  . TYR D 3 204 ? -60.115 1.457   -78.513  1.00 20.72  ? 1548 TYR A CB  1 
ATOM   4040 C CG  . TYR D 3 204 ? -60.488 1.234   -77.056  1.00 30.23  ? 1548 TYR A CG  1 
ATOM   4041 C CD1 . TYR D 3 204 ? -61.820 1.181   -76.652  1.00 34.21  ? 1548 TYR A CD1 1 
ATOM   4042 C CD2 . TYR D 3 204 ? -59.508 1.070   -76.087  1.00 43.51  ? 1548 TYR A CD2 1 
ATOM   4043 C CE1 . TYR D 3 204 ? -62.164 0.974   -75.330  1.00 27.20  ? 1548 TYR A CE1 1 
ATOM   4044 C CE2 . TYR D 3 204 ? -59.843 0.863   -74.760  1.00 47.63  ? 1548 TYR A CE2 1 
ATOM   4045 C CZ  . TYR D 3 204 ? -61.172 0.817   -74.389  1.00 37.30  ? 1548 TYR A CZ  1 
ATOM   4046 O OH  . TYR D 3 204 ? -61.512 0.614   -73.072  1.00 50.40  ? 1548 TYR A OH  1 
ATOM   4047 N N   . GLN D 3 205 ? -62.661 0.935   -80.231  1.00 28.54  ? 1549 GLN A N   1 
ATOM   4048 C CA  . GLN D 3 205 ? -64.101 0.762   -80.390  1.00 28.62  ? 1549 GLN A CA  1 
ATOM   4049 C C   . GLN D 3 205 ? -64.416 -0.623  -80.936  1.00 40.12  ? 1549 GLN A C   1 
ATOM   4050 O O   . GLN D 3 205 ? -65.197 -1.378  -80.345  1.00 46.21  ? 1549 GLN A O   1 
ATOM   4051 C CB  . GLN D 3 205 ? -64.659 1.847   -81.312  1.00 23.62  ? 1549 GLN A CB  1 
ATOM   4052 C CG  . GLN D 3 205 ? -64.412 3.263   -80.823  1.00 14.92  ? 1549 GLN A CG  1 
ATOM   4053 C CD  . GLN D 3 205 ? -65.210 3.595   -79.581  1.00 24.66  ? 1549 GLN A CD  1 
ATOM   4054 O OE1 . GLN D 3 205 ? -66.336 3.125   -79.409  1.00 36.27  ? 1549 GLN A OE1 1 
ATOM   4055 N NE2 . GLN D 3 205 ? -64.628 4.404   -78.702  1.00 32.55  ? 1549 GLN A NE2 1 
ATOM   4056 N N   . ALA D 3 206 ? -63.779 -0.983  -82.051  1.00 40.37  ? 1550 ALA A N   1 
ATOM   4057 C CA  . ALA D 3 206 ? -64.007 -2.285  -82.669  1.00 36.21  ? 1550 ALA A CA  1 
ATOM   4058 C C   . ALA D 3 206 ? -63.740 -3.422  -81.691  1.00 44.33  ? 1550 ALA A C   1 
ATOM   4059 O O   . ALA D 3 206 ? -64.571 -4.323  -81.523  1.00 45.95  ? 1550 ALA A O   1 
ATOM   4060 C CB  . ALA D 3 206 ? -63.119 -2.427  -83.902  1.00 47.76  ? 1550 ALA A CB  1 
ATOM   4061 N N   . GLU D 3 207 ? -62.589 -3.381  -81.019  1.00 46.12  ? 1551 GLU A N   1 
ATOM   4062 C CA  . GLU D 3 207 ? -62.108 -4.543  -80.282  1.00 40.96  ? 1551 GLU A CA  1 
ATOM   4063 C C   . GLU D 3 207 ? -62.740 -4.680  -78.902  1.00 45.50  ? 1551 GLU A C   1 
ATOM   4064 O O   . GLU D 3 207 ? -62.897 -5.804  -78.412  1.00 65.12  ? 1551 GLU A O   1 
ATOM   4065 C CB  . GLU D 3 207 ? -60.585 -4.474  -80.153  1.00 22.16  ? 1551 GLU A CB  1 
ATOM   4066 C CG  . GLU D 3 207 ? -59.861 -4.498  -81.489  1.00 25.32  ? 1551 GLU A CG  1 
ATOM   4067 C CD  . GLU D 3 207 ? -58.520 -5.200  -81.415  1.00 56.61  ? 1551 GLU A CD  1 
ATOM   4068 O OE1 . GLU D 3 207 ? -57.829 -5.055  -80.384  1.00 62.37  ? 1551 GLU A OE1 1 
ATOM   4069 O OE2 . GLU D 3 207 ? -58.159 -5.897  -82.389  1.00 58.17  ? 1551 GLU A OE2 1 
ATOM   4070 N N   . ARG D 3 208 ? -63.114 -3.572  -78.260  1.00 35.92  ? 1552 ARG A N   1 
ATOM   4071 C CA  . ARG D 3 208 ? -63.470 -3.610  -76.848  1.00 38.93  ? 1552 ARG A CA  1 
ATOM   4072 C C   . ARG D 3 208 ? -64.808 -2.970  -76.502  1.00 42.27  ? 1552 ARG A C   1 
ATOM   4073 O O   . ARG D 3 208 ? -65.286 -3.168  -75.380  1.00 48.46  ? 1552 ARG A O   1 
ATOM   4074 C CB  . ARG D 3 208 ? -62.373 -2.931  -76.012  1.00 41.73  ? 1552 ARG A CB  1 
ATOM   4075 C CG  . ARG D 3 208 ? -60.992 -3.541  -76.194  1.00 34.98  ? 1552 ARG A CG  1 
ATOM   4076 C CD  . ARG D 3 208 ? -60.022 -3.055  -75.134  1.00 45.82  ? 1552 ARG A CD  1 
ATOM   4077 N NE  . ARG D 3 208 ? -59.533 -4.158  -74.316  1.00 60.37  ? 1552 ARG A NE  1 
ATOM   4078 C CZ  . ARG D 3 208 ? -60.103 -4.562  -73.190  1.00 65.11  ? 1552 ARG A CZ  1 
ATOM   4079 N NH1 . ARG D 3 208 ? -61.177 -3.960  -72.705  1.00 61.92  ? 1552 ARG A NH1 1 
ATOM   4080 N NH2 . ARG D 3 208 ? -59.585 -5.597  -72.534  1.00 62.68  ? 1552 ARG A NH2 1 
ATOM   4081 N N   . MET D 3 209 ? -65.429 -2.233  -77.413  1.00 31.88  ? 1553 MET A N   1 
ATOM   4082 C CA  . MET D 3 209 ? -66.592 -1.472  -76.978  1.00 27.82  ? 1553 MET A CA  1 
ATOM   4083 C C   . MET D 3 209 ? -67.885 -2.196  -77.334  1.00 35.82  ? 1553 MET A C   1 
ATOM   4084 O O   . MET D 3 209 ? -68.017 -2.713  -78.448  1.00 43.77  ? 1553 MET A O   1 
ATOM   4085 C CB  . MET D 3 209 ? -66.587 -0.093  -77.638  1.00 33.70  ? 1553 MET A CB  1 
ATOM   4086 C CG  . MET D 3 209 ? -65.792 0.957   -76.882  1.00 33.13  ? 1553 MET A CG  1 
ATOM   4087 S SD  . MET D 3 209 ? -66.362 1.189   -75.197  1.00 45.76  ? 1553 MET A SD  1 
ATOM   4088 C CE  . MET D 3 209 ? -68.013 1.795   -75.533  1.00 32.23  ? 1553 MET A CE  1 
ATOM   4089 N N   . PRO D 3 210 ? -68.851 -2.255  -76.416  1.00 29.60  ? 1554 PRO A N   1 
ATOM   4090 C CA  . PRO D 3 210 ? -70.153 -2.844  -76.755  1.00 33.54  ? 1554 PRO A CA  1 
ATOM   4091 C C   . PRO D 3 210 ? -70.835 -2.073  -77.875  1.00 44.91  ? 1554 PRO A C   1 
ATOM   4092 O O   . PRO D 3 210 ? -70.645 -0.865  -78.033  1.00 52.15  ? 1554 PRO A O   1 
ATOM   4093 C CB  . PRO D 3 210 ? -70.945 -2.741  -75.446  1.00 37.36  ? 1554 PRO A CB  1 
ATOM   4094 C CG  . PRO D 3 210 ? -69.906 -2.658  -74.381  1.00 43.84  ? 1554 PRO A CG  1 
ATOM   4095 C CD  . PRO D 3 210 ? -68.766 -1.890  -74.992  1.00 47.12  ? 1554 PRO A CD  1 
ATOM   4096 N N   . GLU D 3 211 ? -71.650 -2.792  -78.651  1.00 62.47  ? 1555 GLU A N   1 
ATOM   4097 C CA  . GLU D 3 211 ? -72.262 -2.204  -79.840  1.00 63.18  ? 1555 GLU A CA  1 
ATOM   4098 C C   . GLU D 3 211 ? -73.222 -1.076  -79.481  1.00 51.39  ? 1555 GLU A C   1 
ATOM   4099 O O   . GLU D 3 211 ? -73.254 -0.041  -80.158  1.00 42.79  ? 1555 GLU A O   1 
ATOM   4100 C CB  . GLU D 3 211 ? -72.988 -3.284  -80.644  1.00 52.49  ? 1555 GLU A CB  1 
ATOM   4101 C CG  . GLU D 3 211 ? -72.120 -4.477  -81.024  1.00 67.43  ? 1555 GLU A CG  1 
ATOM   4102 C CD  . GLU D 3 211 ? -71.223 -4.197  -82.217  1.00 95.21  ? 1555 GLU A CD  1 
ATOM   4103 O OE1 . GLU D 3 211 ? -71.549 -4.657  -83.333  1.00 90.44  ? 1555 GLU A OE1 1 
ATOM   4104 O OE2 . GLU D 3 211 ? -70.185 -3.524  -82.035  1.00 92.47  ? 1555 GLU A OE2 1 
ATOM   4105 N N   . GLN D 3 212 ? -74.006 -1.253  -78.416  1.00 45.18  ? 1556 GLN A N   1 
ATOM   4106 C CA  . GLN D 3 212 ? -75.031 -0.273  -78.072  1.00 48.39  ? 1556 GLN A CA  1 
ATOM   4107 C C   . GLN D 3 212 ? -74.446 1.073   -77.666  1.00 47.82  ? 1556 GLN A C   1 
ATOM   4108 O O   . GLN D 3 212 ? -75.175 2.071   -77.654  1.00 54.25  ? 1556 GLN A O   1 
ATOM   4109 C CB  . GLN D 3 212 ? -75.916 -0.816  -76.949  1.00 52.86  ? 1556 GLN A CB  1 
ATOM   4110 C CG  . GLN D 3 212 ? -76.595 -2.138  -77.278  1.00 46.85  ? 1556 GLN A CG  1 
ATOM   4111 C CD  . GLN D 3 212 ? -75.731 -3.339  -76.944  1.00 57.24  ? 1556 GLN A CD  1 
ATOM   4112 O OE1 . GLN D 3 212 ? -74.539 -3.370  -77.260  1.00 53.55  ? 1556 GLN A OE1 1 
ATOM   4113 N NE2 . GLN D 3 212 ? -76.328 -4.336  -76.301  1.00 64.96  ? 1556 GLN A NE2 1 
ATOM   4114 N N   . ILE D 3 213 ? -73.155 1.128   -77.343  1.00 41.78  ? 1557 ILE A N   1 
ATOM   4115 C CA  . ILE D 3 213 ? -72.495 2.351   -76.911  1.00 39.34  ? 1557 ILE A CA  1 
ATOM   4116 C C   . ILE D 3 213 ? -71.263 2.667   -77.749  1.00 45.69  ? 1557 ILE A C   1 
ATOM   4117 O O   . ILE D 3 213 ? -70.525 3.598   -77.430  1.00 54.10  ? 1557 ILE A O   1 
ATOM   4118 C CB  . ILE D 3 213 ? -72.140 2.282   -75.412  1.00 30.81  ? 1557 ILE A CB  1 
ATOM   4119 C CG1 . ILE D 3 213 ? -71.496 0.937   -75.080  1.00 33.68  ? 1557 ILE A CG1 1 
ATOM   4120 C CG2 . ILE D 3 213 ? -73.374 2.489   -74.557  1.00 41.56  ? 1557 ILE A CG2 1 
ATOM   4121 C CD1 . ILE D 3 213 ? -70.955 0.863   -73.679  1.00 30.25  ? 1557 ILE A CD1 1 
ATOM   4122 N N   . ARG D 3 214 ? -71.036 1.919   -78.825  1.00 28.53  ? 1558 ARG A N   1 
ATOM   4123 C CA  . ARG D 3 214 ? -69.819 2.083   -79.604  1.00 25.85  ? 1558 ARG A CA  1 
ATOM   4124 C C   . ARG D 3 214 ? -69.874 3.350   -80.447  1.00 33.44  ? 1558 ARG A C   1 
ATOM   4125 O O   . ARG D 3 214 ? -70.944 3.822   -80.842  1.00 39.95  ? 1558 ARG A O   1 
ATOM   4126 C CB  . ARG D 3 214 ? -69.596 0.872   -80.510  1.00 45.02  ? 1558 ARG A CB  1 
ATOM   4127 C CG  . ARG D 3 214 ? -68.160 0.707   -80.987  1.00 40.75  ? 1558 ARG A CG  1 
ATOM   4128 C CD  . ARG D 3 214 ? -67.891 -0.706  -81.484  1.00 41.88  ? 1558 ARG A CD  1 
ATOM   4129 N NE  . ARG D 3 214 ? -69.008 -1.260  -82.236  1.00 70.55  ? 1558 ARG A NE  1 
ATOM   4130 C CZ  . ARG D 3 214 ? -69.253 -1.001  -83.514  1.00 87.29  ? 1558 ARG A CZ  1 
ATOM   4131 N NH1 . ARG D 3 214 ? -68.480 -0.189  -84.217  1.00 68.62  ? 1558 ARG A NH1 1 
ATOM   4132 N NH2 . ARG D 3 214 ? -70.301 -1.572  -84.101  1.00 103.04 ? 1558 ARG A NH2 1 
ATOM   4133 N N   . LEU D 3 215 ? -68.694 3.900   -80.720  1.00 31.67  ? 1559 LEU A N   1 
ATOM   4134 C CA  . LEU D 3 215 ? -68.563 5.027   -81.633  1.00 25.04  ? 1559 LEU A CA  1 
ATOM   4135 C C   . LEU D 3 215 ? -68.727 4.531   -83.063  1.00 37.41  ? 1559 LEU A C   1 
ATOM   4136 O O   . LEU D 3 215 ? -67.890 3.774   -83.565  1.00 31.20  ? 1559 LEU A O   1 
ATOM   4137 C CB  . LEU D 3 215 ? -67.210 5.703   -81.444  1.00 24.07  ? 1559 LEU A CB  1 
ATOM   4138 C CG  . LEU D 3 215 ? -67.191 6.954   -80.569  1.00 24.86  ? 1559 LEU A CG  1 
ATOM   4139 C CD1 . LEU D 3 215 ? -65.935 7.765   -80.839  1.00 25.04  ? 1559 LEU A CD1 1 
ATOM   4140 C CD2 . LEU D 3 215 ? -68.436 7.789   -80.816  1.00 38.43  ? 1559 LEU A CD2 1 
ATOM   4141 N N   . LYS D 3 216 ? -69.805 4.949   -83.718  1.00 54.57  ? 1560 LYS A N   1 
ATOM   4142 C CA  . LYS D 3 216 ? -70.029 4.559   -85.102  1.00 47.81  ? 1560 LYS A CA  1 
ATOM   4143 C C   . LYS D 3 216 ? -68.948 5.145   -86.000  1.00 53.53  ? 1560 LYS A C   1 
ATOM   4144 O O   . LYS D 3 216 ? -68.460 6.256   -85.773  1.00 57.29  ? 1560 LYS A O   1 
ATOM   4145 C CB  . LYS D 3 216 ? -71.413 5.013   -85.566  1.00 55.43  ? 1560 LYS A CB  1 
ATOM   4146 C CG  . LYS D 3 216 ? -72.554 4.456   -84.724  1.00 72.51  ? 1560 LYS A CG  1 
ATOM   4147 C CD  . LYS D 3 216 ? -72.514 2.933   -84.692  1.00 65.02  ? 1560 LYS A CD  1 
ATOM   4148 C CE  . LYS D 3 216 ? -73.774 2.351   -84.072  1.00 58.26  ? 1560 LYS A CE  1 
ATOM   4149 N NZ  . LYS D 3 216 ? -74.273 3.177   -82.939  1.00 61.33  ? 1560 LYS A NZ  1 
ATOM   4150 N N   . VAL D 3 217 ? -68.572 4.382   -87.029  1.00 53.71  ? 1561 VAL A N   1 
ATOM   4151 C CA  . VAL D 3 217 ? -67.509 4.811   -87.927  1.00 47.41  ? 1561 VAL A CA  1 
ATOM   4152 C C   . VAL D 3 217 ? -67.939 5.985   -88.798  1.00 52.91  ? 1561 VAL A C   1 
ATOM   4153 O O   . VAL D 3 217 ? -67.086 6.697   -89.339  1.00 60.92  ? 1561 VAL A O   1 
ATOM   4154 C CB  . VAL D 3 217 ? -67.041 3.623   -88.785  1.00 65.01  ? 1561 VAL A CB  1 
ATOM   4155 C CG1 . VAL D 3 217 ? -65.647 3.872   -89.306  1.00 48.02  ? 1561 VAL A CG1 1 
ATOM   4156 C CG2 . VAL D 3 217 ? -67.090 2.329   -87.970  1.00 68.25  ? 1561 VAL A CG2 1 
ATOM   4157 N N   . GLY D 3 218 ? -69.241 6.211   -88.951  1.00 53.09  ? 1562 GLY A N   1 
ATOM   4158 C CA  . GLY D 3 218 ? -69.740 7.366   -89.671  1.00 59.26  ? 1562 GLY A CA  1 
ATOM   4159 C C   . GLY D 3 218 ? -69.797 8.600   -88.797  1.00 57.87  ? 1562 GLY A C   1 
ATOM   4160 O O   . GLY D 3 218 ? -69.014 8.765   -87.853  1.00 53.61  ? 1562 GLY A O   1 
ATOM   4161 N N   . GLY D 3 219 ? -70.743 9.483   -89.113  1.00 62.32  ? 1563 GLY A N   1 
ATOM   4162 C CA  . GLY D 3 219 ? -70.937 10.680  -88.329  1.00 55.64  ? 1563 GLY A CA  1 
ATOM   4163 C C   . GLY D 3 219 ? -71.821 10.455  -87.114  1.00 53.37  ? 1563 GLY A C   1 
ATOM   4164 O O   . GLY D 3 219 ? -72.531 9.456   -87.006  1.00 60.57  ? 1563 GLY A O   1 
ATOM   4165 N N   . VAL D 3 220 ? -71.762 11.414  -86.191  1.00 44.01  ? 1564 VAL A N   1 
ATOM   4166 C CA  . VAL D 3 220 ? -72.578 11.344  -84.990  1.00 39.33  ? 1564 VAL A CA  1 
ATOM   4167 C C   . VAL D 3 220 ? -74.033 11.606  -85.348  1.00 58.61  ? 1564 VAL A C   1 
ATOM   4168 O O   . VAL D 3 220 ? -74.351 12.514  -86.134  1.00 67.92  ? 1564 VAL A O   1 
ATOM   4169 C CB  . VAL D 3 220 ? -72.077 12.347  -83.940  1.00 40.13  ? 1564 VAL A CB  1 
ATOM   4170 C CG1 . VAL D 3 220 ? -73.122 12.554  -82.833  1.00 45.50  ? 1564 VAL A CG1 1 
ATOM   4171 C CG2 . VAL D 3 220 ? -70.762 11.873  -83.366  1.00 52.69  ? 1564 VAL A CG2 1 
ATOM   4172 N N   . ASP D 3 221 ? -74.926 10.789  -84.795  1.00 65.73  ? 1565 ASP A N   1 
ATOM   4173 C CA  . ASP D 3 221 ? -76.349 11.030  -84.954  1.00 73.91  ? 1565 ASP A CA  1 
ATOM   4174 C C   . ASP D 3 221 ? -76.755 12.231  -84.116  1.00 78.11  ? 1565 ASP A C   1 
ATOM   4175 O O   . ASP D 3 221 ? -76.432 12.296  -82.917  1.00 72.56  ? 1565 ASP A O   1 
ATOM   4176 C CB  . ASP D 3 221 ? -77.163 9.812   -84.507  1.00 69.21  ? 1565 ASP A CB  1 
ATOM   4177 C CG  . ASP D 3 221 ? -76.513 8.510   -84.879  1.00 95.41  ? 1565 ASP A CG  1 
ATOM   4178 O OD1 . ASP D 3 221 ? -76.898 7.949   -85.926  1.00 101.33 ? 1565 ASP A OD1 1 
ATOM   4179 O OD2 . ASP D 3 221 ? -75.643 8.034   -84.116  1.00 94.23  ? 1565 ASP A OD2 1 
ATOM   4180 N N   . PRO D 3 222 ? -77.441 13.200  -84.695  1.00 87.37  ? 1566 PRO A N   1 
ATOM   4181 C CA  . PRO D 3 222 ? -78.248 14.102  -83.869  1.00 74.43  ? 1566 PRO A CA  1 
ATOM   4182 C C   . PRO D 3 222 ? -79.174 13.246  -83.008  1.00 71.49  ? 1566 PRO A C   1 
ATOM   4183 O O   . PRO D 3 222 ? -79.697 12.225  -83.478  1.00 81.62  ? 1566 PRO A O   1 
ATOM   4184 C CB  . PRO D 3 222 ? -79.015 14.924  -84.937  1.00 79.06  ? 1566 PRO A CB  1 
ATOM   4185 C CG  . PRO D 3 222 ? -78.904 13.941  -86.136  1.00 75.40  ? 1566 PRO A CG  1 
ATOM   4186 C CD  . PRO D 3 222 ? -77.473 13.708  -86.084  1.00 85.96  ? 1566 PRO A CD  1 
ATOM   4187 N N   . LYS D 3 223 ? -79.359 13.677  -81.753  1.00 66.30  ? 1567 LYS A N   1 
ATOM   4188 C CA  . LYS D 3 223 ? -79.950 12.949  -80.630  1.00 73.45  ? 1567 LYS A CA  1 
ATOM   4189 C C   . LYS D 3 223 ? -78.855 12.289  -79.799  1.00 71.31  ? 1567 LYS A C   1 
ATOM   4190 O O   . LYS D 3 223 ? -79.081 11.928  -78.638  1.00 65.06  ? 1567 LYS A O   1 
ATOM   4191 C CB  . LYS D 3 223 ? -80.982 11.899  -81.062  1.00 72.56  ? 1567 LYS A CB  1 
ATOM   4192 C CG  . LYS D 3 223 ? -82.343 12.477  -81.402  1.00 90.20  ? 1567 LYS A CG  1 
ATOM   4193 C CD  . LYS D 3 223 ? -83.419 11.407  -81.369  1.00 89.78  ? 1567 LYS A CD  1 
ATOM   4194 C CE  . LYS D 3 223 ? -84.670 11.903  -80.669  1.00 74.83  ? 1567 LYS A CE  1 
ATOM   4195 N NZ  . LYS D 3 223 ? -85.227 10.877  -79.751  1.00 79.30  ? 1567 LYS A NZ  1 
ATOM   4196 N N   . GLN D 3 224 ? -77.668 12.117  -80.384  1.00 64.40  ? 1568 GLN A N   1 
ATOM   4197 C CA  . GLN D 3 224 ? -76.473 11.795  -79.618  1.00 62.65  ? 1568 GLN A CA  1 
ATOM   4198 C C   . GLN D 3 224 ? -75.534 12.980  -79.484  1.00 53.41  ? 1568 GLN A C   1 
ATOM   4199 O O   . GLN D 3 224 ? -74.649 12.953  -78.625  1.00 52.50  ? 1568 GLN A O   1 
ATOM   4200 C CB  . GLN D 3 224 ? -75.721 10.621  -80.259  1.00 60.27  ? 1568 GLN A CB  1 
ATOM   4201 C CG  . GLN D 3 224 ? -76.223 9.263   -79.798  1.00 66.41  ? 1568 GLN A CG  1 
ATOM   4202 C CD  . GLN D 3 224 ? -75.104 8.331   -79.384  1.00 72.50  ? 1568 GLN A CD  1 
ATOM   4203 O OE1 . GLN D 3 224 ? -74.982 7.975   -78.209  1.00 74.44  ? 1568 GLN A OE1 1 
ATOM   4204 N NE2 . GLN D 3 224 ? -74.286 7.920   -80.348  1.00 74.03  ? 1568 GLN A NE2 1 
ATOM   4205 N N   . LEU D 3 225 ? -75.714 14.007  -80.311  1.00 47.68  ? 1569 LEU A N   1 
ATOM   4206 C CA  . LEU D 3 225 ? -74.989 15.265  -80.234  1.00 45.17  ? 1569 LEU A CA  1 
ATOM   4207 C C   . LEU D 3 225 ? -75.681 16.272  -79.322  1.00 46.01  ? 1569 LEU A C   1 
ATOM   4208 O O   . LEU D 3 225 ? -75.259 17.432  -79.261  1.00 59.15  ? 1569 LEU A O   1 
ATOM   4209 C CB  . LEU D 3 225 ? -74.828 15.846  -81.645  1.00 52.96  ? 1569 LEU A CB  1 
ATOM   4210 C CG  . LEU D 3 225 ? -73.835 16.972  -81.952  1.00 43.05  ? 1569 LEU A CG  1 
ATOM   4211 C CD1 . LEU D 3 225 ? -72.435 16.421  -82.155  1.00 48.53  ? 1569 LEU A CD1 1 
ATOM   4212 C CD2 . LEU D 3 225 ? -74.286 17.746  -83.182  1.00 26.78  ? 1569 LEU A CD2 1 
ATOM   4213 N N   . ALA D 3 226 ? -76.726 15.848  -78.603  1.00 36.78  ? 1570 ALA A N   1 
ATOM   4214 C CA  . ALA D 3 226 ? -77.535 16.784  -77.830  1.00 35.34  ? 1570 ALA A CA  1 
ATOM   4215 C C   . ALA D 3 226 ? -76.722 17.500  -76.760  1.00 41.11  ? 1570 ALA A C   1 
ATOM   4216 O O   . ALA D 3 226 ? -77.044 18.641  -76.404  1.00 41.77  ? 1570 ALA A O   1 
ATOM   4217 C CB  . ALA D 3 226 ? -78.718 16.054  -77.194  1.00 42.52  ? 1570 ALA A CB  1 
ATOM   4218 N N   . VAL D 3 227 ? -75.678 16.856  -76.232  1.00 38.46  ? 1571 VAL A N   1 
ATOM   4219 C CA  . VAL D 3 227 ? -74.842 17.507  -75.226  1.00 26.23  ? 1571 VAL A CA  1 
ATOM   4220 C C   . VAL D 3 227 ? -74.237 18.781  -75.793  1.00 43.39  ? 1571 VAL A C   1 
ATOM   4221 O O   . VAL D 3 227 ? -74.396 19.871  -75.231  1.00 58.66  ? 1571 VAL A O   1 
ATOM   4222 C CB  . VAL D 3 227 ? -73.747 16.549  -74.723  1.00 26.60  ? 1571 VAL A CB  1 
ATOM   4223 C CG1 . VAL D 3 227 ? -73.255 16.986  -73.354  1.00 27.10  ? 1571 VAL A CG1 1 
ATOM   4224 C CG2 . VAL D 3 227 ? -74.258 15.131  -74.679  1.00 38.15  ? 1571 VAL A CG2 1 
ATOM   4225 N N   . TYR D 3 228 ? -73.555 18.664  -76.936  1.00 46.23  ? 1572 TYR A N   1 
ATOM   4226 C CA  . TYR D 3 228 ? -72.841 19.806  -77.497  1.00 46.09  ? 1572 TYR A CA  1 
ATOM   4227 C C   . TYR D 3 228 ? -73.791 20.924  -77.908  1.00 39.29  ? 1572 TYR A C   1 
ATOM   4228 O O   . TYR D 3 228 ? -73.420 22.102  -77.854  1.00 45.78  ? 1572 TYR A O   1 
ATOM   4229 C CB  . TYR D 3 228 ? -71.982 19.353  -78.678  1.00 31.63  ? 1572 TYR A CB  1 
ATOM   4230 C CG  . TYR D 3 228 ? -70.813 18.490  -78.249  1.00 36.41  ? 1572 TYR A CG  1 
ATOM   4231 C CD1 . TYR D 3 228 ? -69.586 19.060  -77.931  1.00 34.98  ? 1572 TYR A CD1 1 
ATOM   4232 C CD2 . TYR D 3 228 ? -70.939 17.110  -78.150  1.00 40.23  ? 1572 TYR A CD2 1 
ATOM   4233 C CE1 . TYR D 3 228 ? -68.516 18.281  -77.528  1.00 29.07  ? 1572 TYR A CE1 1 
ATOM   4234 C CE2 . TYR D 3 228 ? -69.872 16.320  -77.751  1.00 39.85  ? 1572 TYR A CE2 1 
ATOM   4235 C CZ  . TYR D 3 228 ? -68.663 16.913  -77.441  1.00 33.40  ? 1572 TYR A CZ  1 
ATOM   4236 O OH  . TYR D 3 228 ? -67.595 16.138  -77.043  1.00 38.62  ? 1572 TYR A OH  1 
ATOM   4237 N N   . GLU D 3 229 ? -75.018 20.583  -78.307  1.00 36.71  ? 1573 GLU A N   1 
ATOM   4238 C CA  . GLU D 3 229 ? -76.001 21.621  -78.593  1.00 38.35  ? 1573 GLU A CA  1 
ATOM   4239 C C   . GLU D 3 229 ? -76.442 22.323  -77.313  1.00 42.27  ? 1573 GLU A C   1 
ATOM   4240 O O   . GLU D 3 229 ? -76.648 23.542  -77.304  1.00 46.79  ? 1573 GLU A O   1 
ATOM   4241 C CB  . GLU D 3 229 ? -77.201 21.025  -79.330  1.00 27.99  ? 1573 GLU A CB  1 
ATOM   4242 C CG  . GLU D 3 229 ? -76.881 20.502  -80.726  1.00 42.27  ? 1573 GLU A CG  1 
ATOM   4243 C CD  . GLU D 3 229 ? -76.235 21.552  -81.617  1.00 77.33  ? 1573 GLU A CD  1 
ATOM   4244 O OE1 . GLU D 3 229 ? -76.876 22.593  -81.875  1.00 95.33  ? 1573 GLU A OE1 1 
ATOM   4245 O OE2 . GLU D 3 229 ? -75.086 21.336  -82.063  1.00 74.07  ? 1573 GLU A OE2 1 
ATOM   4246 N N   . GLU D 3 230 ? -76.578 21.571  -76.218  1.00 39.90  ? 1574 GLU A N   1 
ATOM   4247 C CA  . GLU D 3 230 ? -76.972 22.177  -74.951  1.00 35.01  ? 1574 GLU A CA  1 
ATOM   4248 C C   . GLU D 3 230 ? -75.881 23.088  -74.403  1.00 36.93  ? 1574 GLU A C   1 
ATOM   4249 O O   . GLU D 3 230 ? -76.181 24.044  -73.678  1.00 46.98  ? 1574 GLU A O   1 
ATOM   4250 C CB  . GLU D 3 230 ? -77.331 21.086  -73.939  1.00 34.50  ? 1574 GLU A CB  1 
ATOM   4251 C CG  . GLU D 3 230 ? -77.714 21.598  -72.557  1.00 37.12  ? 1574 GLU A CG  1 
ATOM   4252 C CD  . GLU D 3 230 ? -79.074 22.272  -72.526  1.00 45.49  ? 1574 GLU A CD  1 
ATOM   4253 O OE1 . GLU D 3 230 ? -79.815 22.187  -73.530  1.00 50.33  ? 1574 GLU A OE1 1 
ATOM   4254 O OE2 . GLU D 3 230 ? -79.399 22.893  -71.492  1.00 46.95  ? 1574 GLU A OE2 1 
ATOM   4255 N N   . PHE D 3 231 ? -74.615 22.818  -74.744  1.00 39.58  ? 1575 PHE A N   1 
ATOM   4256 C CA  . PHE D 3 231 ? -73.543 23.722  -74.341  1.00 46.43  ? 1575 PHE A CA  1 
ATOM   4257 C C   . PHE D 3 231 ? -73.749 25.114  -74.921  1.00 46.03  ? 1575 PHE A C   1 
ATOM   4258 O O   . PHE D 3 231 ? -73.306 26.108  -74.333  1.00 43.56  ? 1575 PHE A O   1 
ATOM   4259 C CB  . PHE D 3 231 ? -72.181 23.169  -74.768  1.00 37.93  ? 1575 PHE A CB  1 
ATOM   4260 C CG  . PHE D 3 231 ? -71.615 22.160  -73.813  1.00 32.84  ? 1575 PHE A CG  1 
ATOM   4261 C CD1 . PHE D 3 231 ? -70.809 22.562  -72.766  1.00 43.11  ? 1575 PHE A CD1 1 
ATOM   4262 C CD2 . PHE D 3 231 ? -71.863 20.811  -73.976  1.00 36.03  ? 1575 PHE A CD2 1 
ATOM   4263 C CE1 . PHE D 3 231 ? -70.285 21.647  -71.881  1.00 41.69  ? 1575 PHE A CE1 1 
ATOM   4264 C CE2 . PHE D 3 231 ? -71.336 19.886  -73.097  1.00 41.39  ? 1575 PHE A CE2 1 
ATOM   4265 C CZ  . PHE D 3 231 ? -70.544 20.305  -72.049  1.00 49.52  ? 1575 PHE A CZ  1 
ATOM   4266 N N   . ALA D 3 232 ? -74.422 25.202  -76.067  1.00 33.43  ? 1576 ALA A N   1 
ATOM   4267 C CA  . ALA D 3 232 ? -74.735 26.485  -76.676  1.00 36.44  ? 1576 ALA A CA  1 
ATOM   4268 C C   . ALA D 3 232 ? -76.097 27.013  -76.254  1.00 37.30  ? 1576 ALA A C   1 
ATOM   4269 O O   . ALA D 3 232 ? -76.313 28.230  -76.274  1.00 57.32  ? 1576 ALA A O   1 
ATOM   4270 C CB  . ALA D 3 232 ? -74.678 26.368  -78.202  1.00 48.11  ? 1576 ALA A CB  1 
ATOM   4271 N N   . ARG D 3 233 ? -77.020 26.129  -75.871  1.00 33.51  ? 1577 ARG A N   1 
ATOM   4272 C CA  . ARG D 3 233 ? -78.341 26.581  -75.446  1.00 35.46  ? 1577 ARG A CA  1 
ATOM   4273 C C   . ARG D 3 233 ? -78.265 27.311  -74.114  1.00 42.34  ? 1577 ARG A C   1 
ATOM   4274 O O   . ARG D 3 233 ? -78.783 28.426  -73.973  1.00 55.35  ? 1577 ARG A O   1 
ATOM   4275 C CB  . ARG D 3 233 ? -79.301 25.398  -75.353  1.00 31.37  ? 1577 ARG A CB  1 
ATOM   4276 C CG  . ARG D 3 233 ? -80.746 25.775  -75.603  1.00 42.11  ? 1577 ARG A CG  1 
ATOM   4277 C CD  . ARG D 3 233 ? -81.688 25.025  -74.681  1.00 43.92  ? 1577 ARG A CD  1 
ATOM   4278 N NE  . ARG D 3 233 ? -81.677 25.564  -73.328  1.00 36.39  ? 1577 ARG A NE  1 
ATOM   4279 C CZ  . ARG D 3 233 ? -82.040 24.881  -72.251  1.00 52.74  ? 1577 ARG A CZ  1 
ATOM   4280 N NH1 . ARG D 3 233 ? -82.457 23.628  -72.335  1.00 56.54  ? 1577 ARG A NH1 1 
ATOM   4281 N NH2 . ARG D 3 233 ? -81.987 25.471  -71.060  1.00 58.27  ? 1577 ARG A NH2 1 
ATOM   4282 N N   . ASN D 3 234 ? -77.623 26.698  -73.125  1.00 44.13  ? 1578 ASN A N   1 
ATOM   4283 C CA  . ASN D 3 234 ? -77.466 27.279  -71.800  1.00 40.69  ? 1578 ASN A CA  1 
ATOM   4284 C C   . ASN D 3 234 ? -75.989 27.523  -71.535  1.00 36.39  ? 1578 ASN A C   1 
ATOM   4285 O O   . ASN D 3 234 ? -75.209 26.570  -71.434  1.00 45.47  ? 1578 ASN A O   1 
ATOM   4286 C CB  . ASN D 3 234 ? -78.052 26.366  -70.725  1.00 33.14  ? 1578 ASN A CB  1 
ATOM   4287 C CG  . ASN D 3 234 ? -78.426 27.120  -69.472  1.00 46.85  ? 1578 ASN A CG  1 
ATOM   4288 O OD1 . ASN D 3 234 ? -77.676 27.979  -69.003  1.00 45.02  ? 1578 ASN A OD1 1 
ATOM   4289 N ND2 . ASN D 3 234 ? -79.599 26.818  -68.928  1.00 73.63  ? 1578 ASN A ND2 1 
ATOM   4290 N N   . VAL D 3 235 ? -75.613 28.787  -71.417  1.00 26.58  ? 1579 VAL A N   1 
ATOM   4291 C CA  . VAL D 3 235 ? -74.257 29.186  -71.052  1.00 25.96  ? 1579 VAL A CA  1 
ATOM   4292 C C   . VAL D 3 235 ? -74.297 29.722  -69.628  1.00 30.43  ? 1579 VAL A C   1 
ATOM   4293 O O   . VAL D 3 235 ? -75.200 30.501  -69.300  1.00 40.77  ? 1579 VAL A O   1 
ATOM   4294 C CB  . VAL D 3 235 ? -73.688 30.243  -72.017  1.00 20.64  ? 1579 VAL A CB  1 
ATOM   4295 C CG1 . VAL D 3 235 ? -72.382 30.803  -71.482  1.00 14.79  ? 1579 VAL A CG1 1 
ATOM   4296 C CG2 . VAL D 3 235 ? -73.493 29.641  -73.398  1.00 20.30  ? 1579 VAL A CG2 1 
ATOM   4297 N N   . PRO D 3 236 ? -73.376 29.315  -68.757  1.00 34.96  ? 1580 PRO A N   1 
ATOM   4298 C CA  . PRO D 3 236 ? -73.367 29.829  -67.382  1.00 22.35  ? 1580 PRO A CA  1 
ATOM   4299 C C   . PRO D 3 236 ? -73.368 31.350  -67.343  1.00 29.75  ? 1580 PRO A C   1 
ATOM   4300 O O   . PRO D 3 236 ? -72.593 32.010  -68.040  1.00 33.88  ? 1580 PRO A O   1 
ATOM   4301 C CB  . PRO D 3 236 ? -72.062 29.257  -66.803  1.00 23.67  ? 1580 PRO A CB  1 
ATOM   4302 C CG  . PRO D 3 236 ? -71.295 28.736  -68.002  1.00 24.91  ? 1580 PRO A CG  1 
ATOM   4303 C CD  . PRO D 3 236 ? -72.364 28.262  -68.926  1.00 42.30  ? 1580 PRO A CD  1 
ATOM   4304 N N   . GLY D 3 237 ? -74.252 31.906  -66.517  1.00 34.58  ? 1581 GLY A N   1 
ATOM   4305 C CA  . GLY D 3 237 ? -74.320 33.336  -66.308  1.00 30.99  ? 1581 GLY A CA  1 
ATOM   4306 C C   . GLY D 3 237 ? -75.122 34.106  -67.332  1.00 33.46  ? 1581 GLY A C   1 
ATOM   4307 O O   . GLY D 3 237 ? -75.228 35.332  -67.209  1.00 41.03  ? 1581 GLY A O   1 
ATOM   4308 N N   . PHE D 3 238 ? -75.688 33.437  -68.333  1.00 35.70  ? 1582 PHE A N   1 
ATOM   4309 C CA  . PHE D 3 238 ? -76.432 34.100  -69.392  1.00 33.49  ? 1582 PHE A CA  1 
ATOM   4310 C C   . PHE D 3 238 ? -77.791 33.435  -69.553  1.00 34.20  ? 1582 PHE A C   1 
ATOM   4311 O O   . PHE D 3 238 ? -77.983 32.267  -69.202  1.00 34.32  ? 1582 PHE A O   1 
ATOM   4312 C CB  . PHE D 3 238 ? -75.672 34.065  -70.729  1.00 27.83  ? 1582 PHE A CB  1 
ATOM   4313 C CG  . PHE D 3 238 ? -74.413 34.891  -70.738  1.00 27.72  ? 1582 PHE A CG  1 
ATOM   4314 C CD1 . PHE D 3 238 ? -73.244 34.408  -70.172  1.00 30.84  ? 1582 PHE A CD1 1 
ATOM   4315 C CD2 . PHE D 3 238 ? -74.398 36.148  -71.319  1.00 31.90  ? 1582 PHE A CD2 1 
ATOM   4316 C CE1 . PHE D 3 238 ? -72.082 35.167  -70.182  1.00 32.42  ? 1582 PHE A CE1 1 
ATOM   4317 C CE2 . PHE D 3 238 ? -73.240 36.911  -71.333  1.00 32.22  ? 1582 PHE A CE2 1 
ATOM   4318 C CZ  . PHE D 3 238 ? -72.081 36.420  -70.764  1.00 24.75  ? 1582 PHE A CZ  1 
ATOM   4319 N N   . LEU D 3 239 ? -78.736 34.199  -70.086  1.00 39.60  ? 1583 LEU A N   1 
ATOM   4320 C CA  . LEU D 3 239 ? -80.056 33.654  -70.347  1.00 34.25  ? 1583 LEU A CA  1 
ATOM   4321 C C   . LEU D 3 239 ? -79.969 32.615  -71.462  1.00 41.50  ? 1583 LEU A C   1 
ATOM   4322 O O   . LEU D 3 239 ? -79.172 32.769  -72.394  1.00 59.63  ? 1583 LEU A O   1 
ATOM   4323 C CB  . LEU D 3 239 ? -81.027 34.768  -70.739  1.00 33.91  ? 1583 LEU A CB  1 
ATOM   4324 C CG  . LEU D 3 239 ? -81.912 35.350  -69.631  1.00 38.26  ? 1583 LEU A CG  1 
ATOM   4325 C CD1 . LEU D 3 239 ? -82.826 36.421  -70.198  1.00 42.00  ? 1583 LEU A CD1 1 
ATOM   4326 C CD2 . LEU D 3 239 ? -82.730 34.264  -68.947  1.00 36.44  ? 1583 LEU A CD2 1 
ATOM   4327 N N   . PRO D 3 240 ? -80.748 31.537  -71.384  1.00 37.64  ? 1584 PRO A N   1 
ATOM   4328 C CA  . PRO D 3 240 ? -80.774 30.571  -72.491  1.00 41.96  ? 1584 PRO A CA  1 
ATOM   4329 C C   . PRO D 3 240 ? -81.358 31.211  -73.741  1.00 55.40  ? 1584 PRO A C   1 
ATOM   4330 O O   . PRO D 3 240 ? -82.381 31.897  -73.685  1.00 64.71  ? 1584 PRO A O   1 
ATOM   4331 C CB  . PRO D 3 240 ? -81.663 29.439  -71.960  1.00 38.42  ? 1584 PRO A CB  1 
ATOM   4332 C CG  . PRO D 3 240 ? -82.468 30.067  -70.865  1.00 53.23  ? 1584 PRO A CG  1 
ATOM   4333 C CD  . PRO D 3 240 ? -81.573 31.098  -70.247  1.00 41.73  ? 1584 PRO A CD  1 
ATOM   4334 N N   . THR D 3 241 ? -80.685 30.994  -74.874  1.00 69.57  ? 1585 THR A N   1 
ATOM   4335 C CA  . THR D 3 241 ? -81.127 31.601  -76.126  1.00 77.31  ? 1585 THR A CA  1 
ATOM   4336 C C   . THR D 3 241 ? -82.498 31.081  -76.540  1.00 87.52  ? 1585 THR A C   1 
ATOM   4337 O O   . THR D 3 241 ? -83.314 31.828  -77.094  1.00 87.25  ? 1585 THR A O   1 
ATOM   4338 C CB  . THR D 3 241 ? -80.096 31.343  -77.227  1.00 73.16  ? 1585 THR A CB  1 
ATOM   4339 O OG1 . THR D 3 241 ? -80.437 30.143  -77.933  1.00 85.61  ? 1585 THR A OG1 1 
ATOM   4340 C CG2 . THR D 3 241 ? -78.699 31.197  -76.632  1.00 50.27  ? 1585 THR A CG2 1 
ATOM   4341 N N   . ASN D 3 242 ? -82.772 29.803  -76.275  1.00 86.48  ? 1586 ASN A N   1 
ATOM   4342 C CA  . ASN D 3 242 ? -84.060 29.197  -76.581  1.00 83.03  ? 1586 ASN A CA  1 
ATOM   4343 C C   . ASN D 3 242 ? -84.480 28.310  -75.416  1.00 75.90  ? 1586 ASN A C   1 
ATOM   4344 O O   . ASN D 3 242 ? -83.708 28.053  -74.489  1.00 68.28  ? 1586 ASN A O   1 
ATOM   4345 C CB  . ASN D 3 242 ? -84.009 28.399  -77.889  1.00 68.73  ? 1586 ASN A CB  1 
ATOM   4346 C CG  . ASN D 3 242 ? -83.565 29.243  -79.067  1.00 95.44  ? 1586 ASN A CG  1 
ATOM   4347 O OD1 . ASN D 3 242 ? -82.390 29.248  -79.436  1.00 106.23 ? 1586 ASN A OD1 1 
ATOM   4348 N ND2 . ASN D 3 242 ? -84.504 29.976  -79.657  1.00 91.54  ? 1586 ASN A ND2 1 
ATOM   4349 N N   . ASP D 3 243 ? -85.725 27.839  -75.470  1.00 86.43  ? 1587 ASP A N   1 
ATOM   4350 C CA  . ASP D 3 243 ? -86.323 27.057  -74.392  1.00 91.40  ? 1587 ASP A CA  1 
ATOM   4351 C C   . ASP D 3 243 ? -86.616 25.652  -74.903  1.00 82.75  ? 1587 ASP A C   1 
ATOM   4352 O O   . ASP D 3 243 ? -87.554 25.451  -75.682  1.00 94.02  ? 1587 ASP A O   1 
ATOM   4353 C CB  . ASP D 3 243 ? -87.595 27.726  -73.872  1.00 103.08 ? 1587 ASP A CB  1 
ATOM   4354 C CG  . ASP D 3 243 ? -87.307 28.980  -73.069  1.00 109.03 ? 1587 ASP A CG  1 
ATOM   4355 O OD1 . ASP D 3 243 ? -86.731 28.864  -71.965  1.00 100.55 ? 1587 ASP A OD1 1 
ATOM   4356 O OD2 . ASP D 3 243 ? -87.654 30.082  -73.543  1.00 111.67 ? 1587 ASP A OD2 1 
ATOM   4357 N N   . LEU D 3 244 ? -85.816 24.686  -74.463  1.00 81.42  ? 1588 LEU A N   1 
ATOM   4358 C CA  . LEU D 3 244 ? -86.033 23.284  -74.802  1.00 93.94  ? 1588 LEU A CA  1 
ATOM   4359 C C   . LEU D 3 244 ? -85.540 22.390  -73.668  1.00 95.94  ? 1588 LEU A C   1 
ATOM   4360 O O   . LEU D 3 244 ? -84.531 21.697  -73.798  1.00 101.68 ? 1588 LEU A O   1 
ATOM   4361 C CB  . LEU D 3 244 ? -85.328 22.921  -76.113  1.00 83.67  ? 1588 LEU A CB  1 
ATOM   4362 C CG  . LEU D 3 244 ? -86.214 22.760  -77.353  1.00 96.20  ? 1588 LEU A CG  1 
ATOM   4363 C CD1 . LEU D 3 244 ? -85.381 22.798  -78.628  1.00 72.05  ? 1588 LEU A CD1 1 
ATOM   4364 C CD2 . LEU D 3 244 ? -87.030 21.472  -77.280  1.00 85.27  ? 1588 LEU A CD2 1 
ATOM   4365 O OXT . LEU D 3 244 ? -86.137 22.345  -72.592  1.00 79.94  ? 1588 LEU A OXT 1 
ATOM   4366 N N   . GLY E 2 1   ? -21.124 12.690  -109.500 1.00 89.98  ? 13   GLY C N   1 
ATOM   4367 C CA  . GLY E 2 1   ? -21.944 12.264  -110.618 1.00 114.52 ? 13   GLY C CA  1 
ATOM   4368 C C   . GLY E 2 1   ? -23.432 12.450  -110.392 1.00 127.05 ? 13   GLY C C   1 
ATOM   4369 O O   . GLY E 2 1   ? -24.025 13.407  -110.890 1.00 137.54 ? 13   GLY C O   1 
ATOM   4370 N N   . PRO E 2 2   ? -24.041 11.540  -109.645 1.00 135.61 ? 14   PRO C N   1 
ATOM   4371 C CA  . PRO E 2 2   ? -25.490 11.583  -109.429 1.00 142.58 ? 14   PRO C CA  1 
ATOM   4372 C C   . PRO E 2 2   ? -25.858 12.575  -108.328 1.00 133.53 ? 14   PRO C C   1 
ATOM   4373 O O   . PRO E 2 2   ? -25.011 13.270  -107.768 1.00 121.42 ? 14   PRO C O   1 
ATOM   4374 C CB  . PRO E 2 2   ? -25.814 10.145  -109.019 1.00 128.23 ? 14   PRO C CB  1 
ATOM   4375 C CG  . PRO E 2 2   ? -24.578 9.688   -108.322 1.00 117.94 ? 14   PRO C CG  1 
ATOM   4376 C CD  . PRO E 2 2   ? -23.423 10.353  -109.026 1.00 120.60 ? 14   PRO C CD  1 
ATOM   4377 N N   . HIS E 2 3   ? -27.160 12.633  -108.032 1.00 130.31 ? 15   HIS C N   1 
ATOM   4378 C CA  . HIS E 2 3   ? -27.622 13.398  -106.878 1.00 116.52 ? 15   HIS C CA  1 
ATOM   4379 C C   . HIS E 2 3   ? -27.029 12.861  -105.586 1.00 109.26 ? 15   HIS C C   1 
ATOM   4380 O O   . HIS E 2 3   ? -26.841 13.620  -104.628 1.00 104.65 ? 15   HIS C O   1 
ATOM   4381 C CB  . HIS E 2 3   ? -29.150 13.365  -106.787 1.00 96.29  ? 15   HIS C CB  1 
ATOM   4382 C CG  . HIS E 2 3   ? -29.845 14.197  -107.819 1.00 120.62 ? 15   HIS C CG  1 
ATOM   4383 N ND1 . HIS E 2 3   ? -29.169 14.983  -108.727 1.00 124.28 ? 15   HIS C ND1 1 
ATOM   4384 C CD2 . HIS E 2 3   ? -31.163 14.367  -108.083 1.00 114.59 ? 15   HIS C CD2 1 
ATOM   4385 C CE1 . HIS E 2 3   ? -30.039 15.599  -109.507 1.00 117.74 ? 15   HIS C CE1 1 
ATOM   4386 N NE2 . HIS E 2 3   ? -31.256 15.242  -109.138 1.00 120.53 ? 15   HIS C NE2 1 
ATOM   4387 N N   . MET E 2 4   ? -26.709 11.563  -105.549 1.00 118.26 ? 16   MET C N   1 
ATOM   4388 C CA  . MET E 2 4   ? -26.417 10.898  -104.283 1.00 104.94 ? 16   MET C CA  1 
ATOM   4389 C C   . MET E 2 4   ? -25.167 11.469  -103.621 1.00 98.63  ? 16   MET C C   1 
ATOM   4390 O O   . MET E 2 4   ? -25.173 11.749  -102.418 1.00 105.20 ? 16   MET C O   1 
ATOM   4391 C CB  . MET E 2 4   ? -26.299 9.380   -104.494 1.00 105.88 ? 16   MET C CB  1 
ATOM   4392 C CG  . MET E 2 4   ? -24.933 8.864   -104.935 1.00 111.77 ? 16   MET C CG  1 
ATOM   4393 S SD  . MET E 2 4   ? -24.773 7.069   -104.909 1.00 155.21 ? 16   MET C SD  1 
ATOM   4394 C CE  . MET E 2 4   ? -23.519 6.859   -103.646 1.00 85.11  ? 16   MET C CE  1 
ATOM   4395 N N   . LEU E 2 5   ? -24.097 11.691  -104.395 1.00 89.63  ? 17   LEU C N   1 
ATOM   4396 C CA  . LEU E 2 5   ? -22.837 12.127  -103.796 1.00 84.87  ? 17   LEU C CA  1 
ATOM   4397 C C   . LEU E 2 5   ? -23.013 13.429  -103.026 1.00 89.97  ? 17   LEU C C   1 
ATOM   4398 O O   . LEU E 2 5   ? -22.392 13.626  -101.974 1.00 77.38  ? 17   LEU C O   1 
ATOM   4399 C CB  . LEU E 2 5   ? -21.761 12.278  -104.871 1.00 93.21  ? 17   LEU C CB  1 
ATOM   4400 C CG  . LEU E 2 5   ? -21.303 11.001  -105.576 1.00 102.63 ? 17   LEU C CG  1 
ATOM   4401 C CD1 . LEU E 2 5   ? -20.313 11.336  -106.679 1.00 106.19 ? 17   LEU C CD1 1 
ATOM   4402 C CD2 . LEU E 2 5   ? -20.694 10.022  -104.584 1.00 105.02 ? 17   LEU C CD2 1 
ATOM   4403 N N   . GLU E 2 6   ? -23.866 14.324  -103.528 1.00 89.82  ? 18   GLU C N   1 
ATOM   4404 C CA  . GLU E 2 6   ? -24.207 15.527  -102.780 1.00 71.47  ? 18   GLU C CA  1 
ATOM   4405 C C   . GLU E 2 6   ? -25.248 15.239  -101.705 1.00 78.70  ? 18   GLU C C   1 
ATOM   4406 O O   . GLU E 2 6   ? -25.216 15.848  -100.629 1.00 82.52  ? 18   GLU C O   1 
ATOM   4407 C CB  . GLU E 2 6   ? -24.713 16.613  -103.728 1.00 59.15  ? 18   GLU C CB  1 
ATOM   4408 C CG  . GLU E 2 6   ? -24.507 18.018  -103.202 1.00 73.61  ? 18   GLU C CG  1 
ATOM   4409 C CD  . GLU E 2 6   ? -23.180 18.607  -103.635 1.00 92.94  ? 18   GLU C CD  1 
ATOM   4410 O OE1 . GLU E 2 6   ? -22.693 18.238  -104.724 1.00 103.02 ? 18   GLU C OE1 1 
ATOM   4411 O OE2 . GLU E 2 6   ? -22.617 19.430  -102.882 1.00 98.37  ? 18   GLU C OE2 1 
ATOM   4412 N N   A ARG E 2 7   ? -26.175 14.314  -101.971 0.46 76.61  ? 19   ARG C N   1 
ATOM   4413 N N   B ARG E 2 7   ? -26.175 14.317  -101.983 0.54 76.63  ? 19   ARG C N   1 
ATOM   4414 C CA  A ARG E 2 7   ? -27.205 14.003  -100.984 0.46 65.75  ? 19   ARG C CA  1 
ATOM   4415 C CA  B ARG E 2 7   ? -27.204 13.975  -101.006 0.54 65.70  ? 19   ARG C CA  1 
ATOM   4416 C C   A ARG E 2 7   ? -26.609 13.328  -99.753  0.46 65.65  ? 19   ARG C C   1 
ATOM   4417 C C   B ARG E 2 7   ? -26.595 13.346  -99.761  0.54 65.62  ? 19   ARG C C   1 
ATOM   4418 O O   A ARG E 2 7   ? -27.078 13.554  -98.632  0.46 67.93  ? 19   ARG C O   1 
ATOM   4419 O O   B ARG E 2 7   ? -27.042 13.614  -98.640  0.54 67.94  ? 19   ARG C O   1 
ATOM   4420 C CB  A ARG E 2 7   ? -28.294 13.132  -101.613 0.46 62.93  ? 19   ARG C CB  1 
ATOM   4421 C CB  B ARG E 2 7   ? -28.232 13.035  -101.636 0.54 62.88  ? 19   ARG C CB  1 
ATOM   4422 C CG  A ARG E 2 7   ? -29.181 13.884  -102.601 0.46 68.11  ? 19   ARG C CG  1 
ATOM   4423 C CG  B ARG E 2 7   ? -29.673 13.497  -101.495 0.54 66.69  ? 19   ARG C CG  1 
ATOM   4424 C CD  A ARG E 2 7   ? -30.533 13.212  -102.810 0.46 70.10  ? 19   ARG C CD  1 
ATOM   4425 C CD  B ARG E 2 7   ? -30.499 13.112  -102.714 0.54 70.10  ? 19   ARG C CD  1 
ATOM   4426 N NE  A ARG E 2 7   ? -31.226 12.910  -101.564 0.46 65.17  ? 19   ARG C NE  1 
ATOM   4427 N NE  B ARG E 2 7   ? -31.777 13.813  -102.758 0.54 69.70  ? 19   ARG C NE  1 
ATOM   4428 C CZ  A ARG E 2 7   ? -32.330 13.524  -101.159 0.46 56.43  ? 19   ARG C CZ  1 
ATOM   4429 C CZ  B ARG E 2 7   ? -32.010 14.901  -103.479 0.54 65.43  ? 19   ARG C CZ  1 
ATOM   4430 N NH1 A ARG E 2 7   ? -32.871 14.506  -101.860 0.46 61.10  ? 19   ARG C NH1 1 
ATOM   4431 N NH1 B ARG E 2 7   ? -31.069 15.446  -104.233 0.54 65.97  ? 19   ARG C NH1 1 
ATOM   4432 N NH2 A ARG E 2 7   ? -32.906 13.143  -100.022 0.46 52.05  ? 19   ARG C NH2 1 
ATOM   4433 N NH2 B ARG E 2 7   ? -33.219 15.456  -103.445 0.54 58.21  ? 19   ARG C NH2 1 
ATOM   4434 N N   . GLU E 2 8   ? -25.569 12.505  -99.936  1.00 67.51  ? 20   GLU C N   1 
ATOM   4435 C CA  . GLU E 2 8   ? -24.908 11.893  -98.783  1.00 64.29  ? 20   GLU C CA  1 
ATOM   4436 C C   . GLU E 2 8   ? -24.251 12.950  -97.904  1.00 62.33  ? 20   GLU C C   1 
ATOM   4437 O O   . GLU E 2 8   ? -24.247 12.829  -96.673  1.00 69.67  ? 20   GLU C O   1 
ATOM   4438 C CB  . GLU E 2 8   ? -23.866 10.859  -99.226  1.00 65.61  ? 20   GLU C CB  1 
ATOM   4439 C CG  . GLU E 2 8   ? -24.289 9.883   -100.320 1.00 81.22  ? 20   GLU C CG  1 
ATOM   4440 C CD  . GLU E 2 8   ? -25.367 8.909   -99.885  1.00 95.27  ? 20   GLU C CD  1 
ATOM   4441 O OE1 . GLU E 2 8   ? -25.349 8.480   -98.712  1.00 98.92  ? 20   GLU C OE1 1 
ATOM   4442 O OE2 . GLU E 2 8   ? -26.225 8.561   -100.725 1.00 85.09  ? 20   GLU C OE2 1 
ATOM   4443 N N   . LYS E 2 9   ? -23.679 13.989  -98.518  1.00 72.01  ? 21   LYS C N   1 
ATOM   4444 C CA  . LYS E 2 9   ? -23.180 15.122  -97.745  1.00 66.21  ? 21   LYS C CA  1 
ATOM   4445 C C   . LYS E 2 9   ? -24.321 15.815  -97.012  1.00 64.42  ? 21   LYS C C   1 
ATOM   4446 O O   . LYS E 2 9   ? -24.208 16.140  -95.824  1.00 59.13  ? 21   LYS C O   1 
ATOM   4447 C CB  . LYS E 2 9   ? -22.463 16.114  -98.662  1.00 67.88  ? 21   LYS C CB  1 
ATOM   4448 C CG  . LYS E 2 9   ? -21.106 15.660  -99.161  1.00 74.27  ? 21   LYS C CG  1 
ATOM   4449 C CD  . LYS E 2 9   ? -20.660 16.521  -100.332 1.00 72.69  ? 21   LYS C CD  1 
ATOM   4450 C CE  . LYS E 2 9   ? -19.644 15.800  -101.199 1.00 80.42  ? 21   LYS C CE  1 
ATOM   4451 N NZ  . LYS E 2 9   ? -18.873 16.752  -102.044 1.00 63.13  ? 21   LYS C NZ  1 
ATOM   4452 N N   . ILE E 2 10  ? -25.433 16.048  -97.716  1.00 64.95  ? 22   ILE C N   1 
ATOM   4453 C CA  . ILE E 2 10  ? -26.605 16.661  -97.097  1.00 58.33  ? 22   ILE C CA  1 
ATOM   4454 C C   . ILE E 2 10  ? -27.174 15.747  -96.019  1.00 64.65  ? 22   ILE C C   1 
ATOM   4455 O O   . ILE E 2 10  ? -27.525 16.204  -94.924  1.00 73.69  ? 22   ILE C O   1 
ATOM   4456 C CB  . ILE E 2 10  ? -27.655 17.002  -98.171  1.00 50.04  ? 22   ILE C CB  1 
ATOM   4457 C CG1 . ILE E 2 10  ? -27.223 18.244  -98.955  1.00 61.37  ? 22   ILE C CG1 1 
ATOM   4458 C CG2 . ILE E 2 10  ? -29.027 17.207  -97.539  1.00 47.15  ? 22   ILE C CG2 1 
ATOM   4459 C CD1 . ILE E 2 10  ? -28.318 18.851  -99.796  1.00 44.73  ? 22   ILE C CD1 1 
ATOM   4460 N N   . TYR E 2 11  ? -27.268 14.443  -96.306  1.00 63.63  ? 23   TYR C N   1 
ATOM   4461 C CA  . TYR E 2 11  ? -27.676 13.491  -95.275  1.00 49.97  ? 23   TYR C CA  1 
ATOM   4462 C C   . TYR E 2 11  ? -26.792 13.608  -94.044  1.00 51.54  ? 23   TYR C C   1 
ATOM   4463 O O   . TYR E 2 11  ? -27.284 13.551  -92.909  1.00 76.22  ? 23   TYR C O   1 
ATOM   4464 C CB  . TYR E 2 11  ? -27.630 12.059  -95.812  1.00 38.04  ? 23   TYR C CB  1 
ATOM   4465 C CG  . TYR E 2 11  ? -28.690 11.754  -96.842  1.00 47.28  ? 23   TYR C CG  1 
ATOM   4466 C CD1 . TYR E 2 11  ? -29.825 12.547  -96.953  1.00 57.23  ? 23   TYR C CD1 1 
ATOM   4467 C CD2 . TYR E 2 11  ? -28.556 10.676  -97.705  1.00 59.09  ? 23   TYR C CD2 1 
ATOM   4468 C CE1 . TYR E 2 11  ? -30.790 12.275  -97.894  1.00 62.22  ? 23   TYR C CE1 1 
ATOM   4469 C CE2 . TYR E 2 11  ? -29.515 10.396  -98.648  1.00 63.61  ? 23   TYR C CE2 1 
ATOM   4470 C CZ  . TYR E 2 11  ? -30.630 11.199  -98.739  1.00 68.70  ? 23   TYR C CZ  1 
ATOM   4471 O OH  . TYR E 2 11  ? -31.594 10.924  -99.680  1.00 74.49  ? 23   TYR C OH  1 
ATOM   4472 N N   . GLN E 2 12  ? -25.480 13.762  -94.250  1.00 56.64  ? 24   GLN C N   1 
ATOM   4473 C CA  . GLN E 2 12  ? -24.566 13.897  -93.122  1.00 52.09  ? 24   GLN C CA  1 
ATOM   4474 C C   . GLN E 2 12  ? -24.824 15.215  -92.411  1.00 62.88  ? 24   GLN C C   1 
ATOM   4475 O O   . GLN E 2 12  ? -25.212 15.231  -91.239  1.00 70.19  ? 24   GLN C O   1 
ATOM   4476 C CB  . GLN E 2 12  ? -23.102 13.774  -93.616  1.00 59.54  ? 24   GLN C CB  1 
ATOM   4477 C CG  . GLN E 2 12  ? -21.942 13.574  -92.549  1.00 83.23  ? 24   GLN C CG  1 
ATOM   4478 C CD  . GLN E 2 12  ? -21.736 14.657  -91.470  1.00 89.69  ? 24   GLN C CD  1 
ATOM   4479 O OE1 . GLN E 2 12  ? -22.231 15.768  -91.557  1.00 83.38  ? 24   GLN C OE1 1 
ATOM   4480 N NE2 . GLN E 2 12  ? -21.061 14.274  -90.410  1.00 77.07  ? 24   GLN C NE2 1 
ATOM   4481 N N   . TRP E 2 13  ? -24.671 16.333  -93.131  1.00 64.43  ? 25   TRP C N   1 
ATOM   4482 C CA  . TRP E 2 13  ? -24.742 17.671  -92.552  1.00 65.98  ? 25   TRP C CA  1 
ATOM   4483 C C   . TRP E 2 13  ? -25.903 17.813  -91.574  1.00 67.16  ? 25   TRP C C   1 
ATOM   4484 O O   . TRP E 2 13  ? -25.780 18.506  -90.561  1.00 66.79  ? 25   TRP C O   1 
ATOM   4485 C CB  . TRP E 2 13  ? -24.846 18.721  -93.661  1.00 59.92  ? 25   TRP C CB  1 
ATOM   4486 C CG  . TRP E 2 13  ? -23.568 18.974  -94.435  1.00 63.83  ? 25   TRP C CG  1 
ATOM   4487 C CD1 . TRP E 2 13  ? -22.284 18.785  -94.003  1.00 63.99  ? 25   TRP C CD1 1 
ATOM   4488 C CD2 . TRP E 2 13  ? -23.464 19.478  -95.776  1.00 62.37  ? 25   TRP C CD2 1 
ATOM   4489 N NE1 . TRP E 2 13  ? -21.393 19.134  -94.993  1.00 65.78  ? 25   TRP C NE1 1 
ATOM   4490 C CE2 . TRP E 2 13  ? -22.093 19.562  -96.090  1.00 63.57  ? 25   TRP C CE2 1 
ATOM   4491 C CE3 . TRP E 2 13  ? -24.399 19.860  -96.745  1.00 60.81  ? 25   TRP C CE3 1 
ATOM   4492 C CZ2 . TRP E 2 13  ? -21.638 20.014  -97.329  1.00 72.98  ? 25   TRP C CZ2 1 
ATOM   4493 C CZ3 . TRP E 2 13  ? -23.946 20.310  -97.970  1.00 53.65  ? 25   TRP C CZ3 1 
ATOM   4494 C CH2 . TRP E 2 13  ? -22.581 20.383  -98.253  1.00 63.81  ? 25   TRP C CH2 1 
ATOM   4495 N N   . ILE E 2 14  ? -27.018 17.133  -91.857  1.00 63.58  ? 26   ILE C N   1 
ATOM   4496 C CA  . ILE E 2 14  ? -28.131 17.078  -90.913  1.00 50.54  ? 26   ILE C CA  1 
ATOM   4497 C C   . ILE E 2 14  ? -27.698 16.423  -89.603  1.00 59.36  ? 26   ILE C C   1 
ATOM   4498 O O   . ILE E 2 14  ? -28.039 16.898  -88.512  1.00 68.70  ? 26   ILE C O   1 
ATOM   4499 C CB  . ILE E 2 14  ? -29.322 16.343  -91.556  1.00 45.46  ? 26   ILE C CB  1 
ATOM   4500 C CG1 . ILE E 2 14  ? -29.771 17.082  -92.820  1.00 46.95  ? 26   ILE C CG1 1 
ATOM   4501 C CG2 . ILE E 2 14  ? -30.467 16.204  -90.568  1.00 49.05  ? 26   ILE C CG2 1 
ATOM   4502 C CD1 . ILE E 2 14  ? -31.157 16.719  -93.297  1.00 51.26  ? 26   ILE C CD1 1 
ATOM   4503 N N   . ASN E 2 15  ? -26.936 15.326  -89.685  1.00 71.22  ? 27   ASN C N   1 
ATOM   4504 C CA  . ASN E 2 15  ? -26.454 14.674  -88.469  1.00 68.93  ? 27   ASN C CA  1 
ATOM   4505 C C   . ASN E 2 15  ? -25.402 15.521  -87.761  1.00 61.78  ? 27   ASN C C   1 
ATOM   4506 O O   . ASN E 2 15  ? -25.291 15.464  -86.531  1.00 74.09  ? 27   ASN C O   1 
ATOM   4507 C CB  . ASN E 2 15  ? -25.883 13.287  -88.789  1.00 68.81  ? 27   ASN C CB  1 
ATOM   4508 C CG  . ASN E 2 15  ? -26.943 12.307  -89.277  1.00 79.28  ? 27   ASN C CG  1 
ATOM   4509 O OD1 . ASN E 2 15  ? -27.914 12.694  -89.929  1.00 73.04  ? 27   ASN C OD1 1 
ATOM   4510 N ND2 . ASN E 2 15  ? -26.754 11.027  -88.967  1.00 81.78  ? 27   ASN C ND2 1 
ATOM   4511 N N   . GLU E 2 16  ? -24.623 16.307  -88.510  1.00 56.80  ? 28   GLU C N   1 
ATOM   4512 C CA  . GLU E 2 16  ? -23.633 17.191  -87.902  1.00 67.91  ? 28   GLU C CA  1 
ATOM   4513 C C   . GLU E 2 16  ? -24.253 18.309  -87.076  1.00 62.63  ? 28   GLU C C   1 
ATOM   4514 O O   . GLU E 2 16  ? -23.539 18.945  -86.293  1.00 69.21  ? 28   GLU C O   1 
ATOM   4515 C CB  . GLU E 2 16  ? -22.726 17.804  -88.972  1.00 82.87  ? 28   GLU C CB  1 
ATOM   4516 C CG  . GLU E 2 16  ? -21.341 17.200  -89.039  1.00 85.79  ? 28   GLU C CG  1 
ATOM   4517 C CD  . GLU E 2 16  ? -20.448 17.843  -90.091  1.00 82.88  ? 28   GLU C CD  1 
ATOM   4518 O OE1 . GLU E 2 16  ? -20.106 19.036  -89.951  1.00 69.02  ? 28   GLU C OE1 1 
ATOM   4519 O OE2 . GLU E 2 16  ? -20.061 17.146  -91.050  1.00 101.88 ? 28   GLU C OE2 1 
ATOM   4520 N N   . LEU E 2 17  ? -25.552 18.565  -87.228  1.00 57.49  ? 29   LEU C N   1 
ATOM   4521 C CA  A LEU E 2 17  ? -26.183 19.646  -86.484  0.86 56.21  ? 29   LEU C CA  1 
ATOM   4522 C CA  B LEU E 2 17  ? -26.193 19.642  -86.485  0.14 56.40  ? 29   LEU C CA  1 
ATOM   4523 C C   . LEU E 2 17  ? -26.319 19.332  -85.000  1.00 65.02  ? 29   LEU C C   1 
ATOM   4524 O O   . LEU E 2 17  ? -26.514 20.254  -84.201  1.00 64.14  ? 29   LEU C O   1 
ATOM   4525 C CB  A LEU E 2 17  ? -27.554 19.960  -87.083  0.86 48.38  ? 29   LEU C CB  1 
ATOM   4526 C CB  B LEU E 2 17  ? -27.574 19.930  -87.074  0.14 49.12  ? 29   LEU C CB  1 
ATOM   4527 C CG  A LEU E 2 17  ? -27.528 20.496  -88.515  0.86 43.71  ? 29   LEU C CG  1 
ATOM   4528 C CG  B LEU E 2 17  ? -27.714 21.209  -87.900  0.14 47.75  ? 29   LEU C CG  1 
ATOM   4529 C CD1 A LEU E 2 17  ? -28.910 20.445  -89.146  0.86 36.51  ? 29   LEU C CD1 1 
ATOM   4530 C CD1 B LEU E 2 17  ? -27.410 20.947  -89.365  0.14 49.49  ? 29   LEU C CD1 1 
ATOM   4531 C CD2 A LEU E 2 17  ? -26.980 21.908  -88.533  0.86 50.43  ? 29   LEU C CD2 1 
ATOM   4532 C CD2 B LEU E 2 17  ? -29.108 21.779  -87.743  0.14 44.23  ? 29   LEU C CD2 1 
ATOM   4533 N N   . SER E 2 18  ? -26.215 18.060  -84.610  1.00 62.55  ? 30   SER C N   1 
ATOM   4534 C CA  . SER E 2 18  ? -26.375 17.703  -83.203  1.00 55.53  ? 30   SER C CA  1 
ATOM   4535 C C   . SER E 2 18  ? -25.195 18.192  -82.370  1.00 69.13  ? 30   SER C C   1 
ATOM   4536 O O   . SER E 2 18  ? -25.359 19.014  -81.461  1.00 67.70  ? 30   SER C O   1 
ATOM   4537 C CB  . SER E 2 18  ? -26.555 16.190  -83.060  1.00 74.61  ? 30   SER C CB  1 
ATOM   4538 O OG  . SER E 2 18  ? -27.442 15.686  -84.045  1.00 75.00  ? 30   SER C OG  1 
ATOM   4539 N N   . SER E 2 19  ? -23.998 17.700  -82.668  1.00 74.43  ? 31   SER C N   1 
ATOM   4540 C CA  . SER E 2 19  ? -22.828 18.065  -81.881  1.00 71.05  ? 31   SER C CA  1 
ATOM   4541 C C   . SER E 2 19  ? -22.551 19.561  -82.008  1.00 75.40  ? 31   SER C C   1 
ATOM   4542 O O   . SER E 2 19  ? -22.502 20.086  -83.130  1.00 72.90  ? 31   SER C O   1 
ATOM   4543 C CB  . SER E 2 19  ? -21.607 17.266  -82.332  1.00 75.65  ? 31   SER C CB  1 
ATOM   4544 O OG  . SER E 2 19  ? -20.410 17.961  -82.030  1.00 86.07  ? 31   SER C OG  1 
ATOM   4545 N N   . PRO E 2 20  ? -22.369 20.279  -80.896  1.00 68.80  ? 32   PRO C N   1 
ATOM   4546 C CA  . PRO E 2 20  ? -22.074 21.718  -80.992  1.00 77.13  ? 32   PRO C CA  1 
ATOM   4547 C C   . PRO E 2 20  ? -20.739 22.015  -81.652  1.00 79.10  ? 32   PRO C C   1 
ATOM   4548 O O   . PRO E 2 20  ? -20.510 23.159  -82.069  1.00 54.95  ? 32   PRO C O   1 
ATOM   4549 C CB  . PRO E 2 20  ? -22.091 22.181  -79.526  1.00 66.00  ? 32   PRO C CB  1 
ATOM   4550 C CG  . PRO E 2 20  ? -22.814 21.093  -78.777  1.00 58.13  ? 32   PRO C CG  1 
ATOM   4551 C CD  . PRO E 2 20  ? -22.481 19.828  -79.500  1.00 59.38  ? 32   PRO C CD  1 
ATOM   4552 N N   . GLU E 2 21  ? -19.853 21.023  -81.758  1.00 87.17  ? 33   GLU C N   1 
ATOM   4553 C CA  . GLU E 2 21  ? -18.567 21.221  -82.413  1.00 83.30  ? 33   GLU C CA  1 
ATOM   4554 C C   . GLU E 2 21  ? -18.723 21.265  -83.927  1.00 68.66  ? 33   GLU C C   1 
ATOM   4555 O O   . GLU E 2 21  ? -18.189 22.158  -84.593  1.00 76.96  ? 33   GLU C O   1 
ATOM   4556 C CB  . GLU E 2 21  ? -17.602 20.105  -82.006  1.00 80.85  ? 33   GLU C CB  1 
ATOM   4557 C CG  . GLU E 2 21  ? -17.656 19.750  -80.528  1.00 93.42  ? 33   GLU C CG  1 
ATOM   4558 C CD  . GLU E 2 21  ? -16.342 19.200  -80.009  1.00 100.12 ? 33   GLU C CD  1 
ATOM   4559 O OE1 . GLU E 2 21  ? -16.137 17.971  -80.094  1.00 100.41 ? 33   GLU C OE1 1 
ATOM   4560 O OE2 . GLU E 2 21  ? -15.517 19.995  -79.512  1.00 101.16 ? 33   GLU C OE2 1 
ATOM   4561 N N   . THR E 2 22  ? -19.459 20.310  -84.481  1.00 58.12  ? 34   THR C N   1 
ATOM   4562 C CA  . THR E 2 22  ? -19.670 20.196  -85.915  1.00 66.50  ? 34   THR C CA  1 
ATOM   4563 C C   . THR E 2 22  ? -20.895 20.963  -86.400  1.00 64.90  ? 34   THR C C   1 
ATOM   4564 O O   . THR E 2 22  ? -21.263 20.842  -87.573  1.00 63.15  ? 34   THR C O   1 
ATOM   4565 C CB  . THR E 2 22  ? -19.795 18.722  -86.292  1.00 72.02  ? 34   THR C CB  1 
ATOM   4566 O OG1 . THR E 2 22  ? -21.164 18.317  -86.163  1.00 77.83  ? 34   THR C OG1 1 
ATOM   4567 C CG2 . THR E 2 22  ? -18.929 17.865  -85.382  1.00 73.05  ? 34   THR C CG2 1 
ATOM   4568 N N   . ARG E 2 23  ? -21.522 21.757  -85.532  1.00 62.69  ? 35   ARG C N   1 
ATOM   4569 C CA  . ARG E 2 23  ? -22.782 22.404  -85.882  1.00 62.78  ? 35   ARG C CA  1 
ATOM   4570 C C   . ARG E 2 23  ? -22.578 23.617  -86.781  1.00 50.44  ? 35   ARG C C   1 
ATOM   4571 O O   . ARG E 2 23  ? -23.363 23.840  -87.711  1.00 45.58  ? 35   ARG C O   1 
ATOM   4572 C CB  . ARG E 2 23  ? -23.523 22.812  -84.611  1.00 73.58  ? 35   ARG C CB  1 
ATOM   4573 C CG  . ARG E 2 23  ? -25.009 23.056  -84.798  1.00 71.78  ? 35   ARG C CG  1 
ATOM   4574 C CD  . ARG E 2 23  ? -25.525 24.002  -83.730  1.00 56.87  ? 35   ARG C CD  1 
ATOM   4575 N NE  . ARG E 2 23  ? -25.126 23.561  -82.398  1.00 70.50  ? 35   ARG C NE  1 
ATOM   4576 C CZ  . ARG E 2 23  ? -25.834 22.740  -81.634  1.00 64.54  ? 35   ARG C CZ  1 
ATOM   4577 N NH1 . ARG E 2 23  ? -27.009 22.276  -82.023  1.00 60.15  ? 35   ARG C NH1 1 
ATOM   4578 N NH2 . ARG E 2 23  ? -25.351 22.376  -80.450  1.00 56.60  ? 35   ARG C NH2 1 
ATOM   4579 N N   . GLU E 2 24  ? -21.543 24.415  -86.514  1.00 54.21  ? 36   GLU C N   1 
ATOM   4580 C CA  . GLU E 2 24  ? -21.354 25.660  -87.253  1.00 59.95  ? 36   GLU C CA  1 
ATOM   4581 C C   . GLU E 2 24  ? -21.168 25.399  -88.744  1.00 61.32  ? 36   GLU C C   1 
ATOM   4582 O O   . GLU E 2 24  ? -21.780 26.071  -89.583  1.00 51.41  ? 36   GLU C O   1 
ATOM   4583 C CB  . GLU E 2 24  ? -20.162 26.428  -86.685  1.00 64.42  ? 36   GLU C CB  1 
ATOM   4584 C CG  . GLU E 2 24  ? -20.197 27.919  -86.966  1.00 58.59  ? 36   GLU C CG  1 
ATOM   4585 C CD  . GLU E 2 24  ? -19.150 28.682  -86.181  1.00 74.31  ? 36   GLU C CD  1 
ATOM   4586 O OE1 . GLU E 2 24  ? -18.590 28.108  -85.223  1.00 78.40  ? 36   GLU C OE1 1 
ATOM   4587 O OE2 . GLU E 2 24  ? -18.885 29.853  -86.524  1.00 84.55  ? 36   GLU C OE2 1 
ATOM   4588 N N   . ASN E 2 25  ? -20.330 24.418  -89.092  1.00 66.71  ? 37   ASN C N   1 
ATOM   4589 C CA  . ASN E 2 25  ? -20.073 24.129  -90.501  1.00 56.67  ? 37   ASN C CA  1 
ATOM   4590 C C   . ASN E 2 25  ? -21.312 23.572  -91.187  1.00 61.08  ? 37   ASN C C   1 
ATOM   4591 O O   . ASN E 2 25  ? -21.600 23.919  -92.339  1.00 69.51  ? 37   ASN C O   1 
ATOM   4592 C CB  . ASN E 2 25  ? -18.906 23.151  -90.638  1.00 63.13  ? 37   ASN C CB  1 
ATOM   4593 C CG  . ASN E 2 25  ? -18.570 22.842  -92.087  1.00 64.75  ? 37   ASN C CG  1 
ATOM   4594 O OD1 . ASN E 2 25  ? -17.957 23.654  -92.780  1.00 63.09  ? 37   ASN C OD1 1 
ATOM   4595 N ND2 . ASN E 2 25  ? -18.975 21.664  -92.551  1.00 70.08  ? 37   ASN C ND2 1 
ATOM   4596 N N   . ALA E 2 26  ? -22.055 22.702  -90.500  1.00 59.65  ? 38   ALA C N   1 
ATOM   4597 C CA  . ALA E 2 26  ? -23.263 22.140  -91.092  1.00 58.50  ? 38   ALA C CA  1 
ATOM   4598 C C   . ALA E 2 26  ? -24.322 23.213  -91.310  1.00 53.67  ? 38   ALA C C   1 
ATOM   4599 O O   . ALA E 2 26  ? -25.057 23.172  -92.304  1.00 53.06  ? 38   ALA C O   1 
ATOM   4600 C CB  . ALA E 2 26  ? -23.804 21.018  -90.210  1.00 59.93  ? 38   ALA C CB  1 
ATOM   4601 N N   . LEU E 2 27  ? -24.412 24.182  -90.395  1.00 53.30  ? 39   LEU C N   1 
ATOM   4602 C CA  . LEU E 2 27  ? -25.389 25.257  -90.544  1.00 45.50  ? 39   LEU C CA  1 
ATOM   4603 C C   . LEU E 2 27  ? -25.141 26.055  -91.818  1.00 59.08  ? 39   LEU C C   1 
ATOM   4604 O O   . LEU E 2 27  ? -26.089 26.443  -92.512  1.00 68.64  ? 39   LEU C O   1 
ATOM   4605 C CB  . LEU E 2 27  ? -25.344 26.174  -89.320  1.00 58.13  ? 39   LEU C CB  1 
ATOM   4606 C CG  . LEU E 2 27  ? -26.256 25.850  -88.132  1.00 50.30  ? 39   LEU C CG  1 
ATOM   4607 C CD1 . LEU E 2 27  ? -26.325 27.027  -87.173  1.00 47.48  ? 39   LEU C CD1 1 
ATOM   4608 C CD2 . LEU E 2 27  ? -27.649 25.476  -88.601  1.00 41.38  ? 39   LEU C CD2 1 
ATOM   4609 N N   . LEU E 2 28  ? -23.871 26.297  -92.148  1.00 65.80  ? 40   LEU C N   1 
ATOM   4610 C CA  . LEU E 2 28  ? -23.543 27.119  -93.308  1.00 65.41  ? 40   LEU C CA  1 
ATOM   4611 C C   . LEU E 2 28  ? -23.886 26.406  -94.611  1.00 65.55  ? 40   LEU C C   1 
ATOM   4612 O O   . LEU E 2 28  ? -24.613 26.947  -95.453  1.00 73.50  ? 40   LEU C O   1 
ATOM   4613 C CB  . LEU E 2 28  ? -22.063 27.497  -93.276  1.00 55.36  ? 40   LEU C CB  1 
ATOM   4614 C CG  . LEU E 2 28  ? -21.587 28.491  -94.336  1.00 74.07  ? 40   LEU C CG  1 
ATOM   4615 C CD1 . LEU E 2 28  ? -22.588 29.627  -94.506  1.00 89.99  ? 40   LEU C CD1 1 
ATOM   4616 C CD2 . LEU E 2 28  ? -20.207 29.028  -93.986  1.00 91.36  ? 40   LEU C CD2 1 
ATOM   4617 N N   . GLU E 2 29  ? -23.369 25.189  -94.796  1.00 59.98  ? 41   GLU C N   1 
ATOM   4618 C CA  . GLU E 2 29  ? -23.580 24.479  -96.054  1.00 63.16  ? 41   GLU C CA  1 
ATOM   4619 C C   . GLU E 2 29  ? -25.051 24.133  -96.263  1.00 67.02  ? 41   GLU C C   1 
ATOM   4620 O O   . GLU E 2 29  ? -25.548 24.182  -97.395  1.00 72.74  ? 41   GLU C O   1 
ATOM   4621 C CB  . GLU E 2 29  ? -22.719 23.216  -96.095  1.00 67.09  ? 41   GLU C CB  1 
ATOM   4622 C CG  . GLU E 2 29  ? -21.303 23.412  -95.572  1.00 84.69  ? 41   GLU C CG  1 
ATOM   4623 C CD  . GLU E 2 29  ? -20.317 23.782  -96.667  1.00 89.28  ? 41   GLU C CD  1 
ATOM   4624 O OE1 . GLU E 2 29  ? -19.854 22.871  -97.387  1.00 86.77  ? 41   GLU C OE1 1 
ATOM   4625 O OE2 . GLU E 2 29  ? -20.004 24.984  -96.807  1.00 82.59  ? 41   GLU C OE2 1 
ATOM   4626 N N   . LEU E 2 30  ? -25.761 23.780  -95.188  1.00 61.08  ? 42   LEU C N   1 
ATOM   4627 C CA  . LEU E 2 30  ? -27.177 23.438  -95.310  1.00 53.33  ? 42   LEU C CA  1 
ATOM   4628 C C   . LEU E 2 30  ? -28.020 24.644  -95.696  1.00 52.31  ? 42   LEU C C   1 
ATOM   4629 O O   . LEU E 2 30  ? -28.987 24.513  -96.456  1.00 58.76  ? 42   LEU C O   1 
ATOM   4630 C CB  . LEU E 2 30  ? -27.679 22.816  -94.007  1.00 46.40  ? 42   LEU C CB  1 
ATOM   4631 C CG  . LEU E 2 30  ? -27.330 21.342  -93.814  1.00 39.87  ? 42   LEU C CG  1 
ATOM   4632 C CD1 . LEU E 2 30  ? -28.340 20.645  -92.928  1.00 51.25  ? 42   LEU C CD1 1 
ATOM   4633 C CD2 . LEU E 2 30  ? -27.357 20.694  -95.180  1.00 39.46  ? 42   LEU C CD2 1 
ATOM   4634 N N   . SER E 2 31  ? -27.675 25.826  -95.188  1.00 47.79  ? 43   SER C N   1 
ATOM   4635 C CA  . SER E 2 31  ? -28.424 27.021  -95.553  1.00 59.51  ? 43   SER C CA  1 
ATOM   4636 C C   . SER E 2 31  ? -28.173 27.440  -96.995  1.00 76.35  ? 43   SER C C   1 
ATOM   4637 O O   . SER E 2 31  ? -29.009 28.137  -97.578  1.00 81.82  ? 43   SER C O   1 
ATOM   4638 C CB  . SER E 2 31  ? -28.079 28.162  -94.602  1.00 55.21  ? 43   SER C CB  1 
ATOM   4639 O OG  . SER E 2 31  ? -28.218 29.418  -95.244  1.00 69.13  ? 43   SER C OG  1 
ATOM   4640 N N   . LYS E 2 32  ? -27.042 27.039  -97.583  1.00 76.41  ? 44   LYS C N   1 
ATOM   4641 C CA  . LYS E 2 32  ? -26.814 27.316  -98.997  1.00 65.74  ? 44   LYS C CA  1 
ATOM   4642 C C   . LYS E 2 32  ? -27.665 26.416  -99.883  1.00 68.43  ? 44   LYS C C   1 
ATOM   4643 O O   . LYS E 2 32  ? -28.105 26.841  -100.959 1.00 72.43  ? 44   LYS C O   1 
ATOM   4644 C CB  . LYS E 2 32  ? -25.335 27.140  -99.343  1.00 59.86  ? 44   LYS C CB  1 
ATOM   4645 C CG  . LYS E 2 32  ? -24.386 28.024  -98.550  1.00 71.24  ? 44   LYS C CG  1 
ATOM   4646 C CD  . LYS E 2 32  ? -22.943 27.820  -98.997  1.00 67.68  ? 44   LYS C CD  1 
ATOM   4647 C CE  . LYS E 2 32  ? -22.061 28.992  -98.585  1.00 58.21  ? 44   LYS C CE  1 
ATOM   4648 N NZ  . LYS E 2 32  ? -20.615 28.633  -98.602  1.00 51.20  ? 44   LYS C NZ  1 
ATOM   4649 N N   . LYS E 2 33  ? -27.915 25.184  -99.447  1.00 70.68  ? 45   LYS C N   1 
ATOM   4650 C CA  . LYS E 2 33  ? -28.601 24.183  -100.248 1.00 64.66  ? 45   LYS C CA  1 
ATOM   4651 C C   . LYS E 2 33  ? -30.098 24.114  -99.978  1.00 72.80  ? 45   LYS C C   1 
ATOM   4652 O O   . LYS E 2 33  ? -30.772 23.255  -100.554 1.00 76.75  ? 45   LYS C O   1 
ATOM   4653 C CB  . LYS E 2 33  ? -27.981 22.803  -100.001 1.00 60.06  ? 45   LYS C CB  1 
ATOM   4654 C CG  . LYS E 2 33  ? -26.615 22.604  -100.633 1.00 75.70  ? 45   LYS C CG  1 
ATOM   4655 C CD  . LYS E 2 33  ? -26.736 22.275  -102.111 1.00 78.08  ? 45   LYS C CD  1 
ATOM   4656 C CE  . LYS E 2 33  ? -25.621 21.350  -102.556 1.00 59.51  ? 45   LYS C CE  1 
ATOM   4657 N NZ  . LYS E 2 33  ? -24.442 21.445  -101.652 1.00 71.48  ? 45   LYS C NZ  1 
ATOM   4658 N N   . ARG E 2 34  ? -30.638 24.996  -99.130  1.00 73.58  ? 46   ARG C N   1 
ATOM   4659 C CA  . ARG E 2 34  ? -32.042 24.891  -98.741  1.00 61.60  ? 46   ARG C CA  1 
ATOM   4660 C C   . ARG E 2 34  ? -32.993 25.059  -99.920  1.00 68.24  ? 46   ARG C C   1 
ATOM   4661 O O   . ARG E 2 34  ? -34.174 24.713  -99.801  1.00 63.63  ? 46   ARG C O   1 
ATOM   4662 C CB  . ARG E 2 34  ? -32.375 25.919  -97.656  1.00 57.03  ? 46   ARG C CB  1 
ATOM   4663 C CG  . ARG E 2 34  ? -32.393 27.361  -98.135  1.00 67.33  ? 46   ARG C CG  1 
ATOM   4664 C CD  . ARG E 2 34  ? -32.036 28.316  -97.009  1.00 60.16  ? 46   ARG C CD  1 
ATOM   4665 N NE  . ARG E 2 34  ? -32.706 29.603  -97.149  1.00 72.77  ? 46   ARG C NE  1 
ATOM   4666 C CZ  . ARG E 2 34  ? -32.088 30.776  -97.119  1.00 70.80  ? 46   ARG C CZ  1 
ATOM   4667 N NH1 . ARG E 2 34  ? -30.777 30.863  -96.958  1.00 65.22  ? 46   ARG C NH1 1 
ATOM   4668 N NH2 . ARG E 2 34  ? -32.802 31.890  -97.253  1.00 68.65  ? 46   ARG C NH2 1 
ATOM   4669 N N   . GLU E 2 35  ? -32.511 25.575  -101.049 1.00 80.67  ? 47   GLU C N   1 
ATOM   4670 C CA  . GLU E 2 35  ? -33.332 25.731  -102.243 1.00 81.80  ? 47   GLU C CA  1 
ATOM   4671 C C   . GLU E 2 35  ? -33.173 24.589  -103.237 1.00 71.31  ? 47   GLU C C   1 
ATOM   4672 O O   . GLU E 2 35  ? -34.130 24.266  -103.948 1.00 58.63  ? 47   GLU C O   1 
ATOM   4673 C CB  . GLU E 2 35  ? -33.002 27.053  -102.945 1.00 85.57  ? 47   GLU C CB  1 
ATOM   4674 C CG  . GLU E 2 35  ? -33.233 28.289  -102.089 1.00 98.96  ? 47   GLU C CG  1 
ATOM   4675 C CD  . GLU E 2 35  ? -34.474 29.059  -102.499 1.00 107.59 ? 47   GLU C CD  1 
ATOM   4676 O OE1 . GLU E 2 35  ? -35.402 28.437  -103.058 1.00 99.11  ? 47   GLU C OE1 1 
ATOM   4677 O OE2 . GLU E 2 35  ? -34.521 30.285  -102.263 1.00 113.20 ? 47   GLU C OE2 1 
ATOM   4678 N N   . SER E 2 36  ? -31.995 23.963  -103.299 1.00 79.42  ? 48   SER C N   1 
ATOM   4679 C CA  . SER E 2 36  ? -31.755 22.933  -104.305 1.00 75.63  ? 48   SER C CA  1 
ATOM   4680 C C   . SER E 2 36  ? -32.445 21.618  -103.953 1.00 77.55  ? 48   SER C C   1 
ATOM   4681 O O   . SER E 2 36  ? -32.941 20.922  -104.847 1.00 79.19  ? 48   SER C O   1 
ATOM   4682 C CB  . SER E 2 36  ? -30.252 22.722  -104.489 1.00 59.38  ? 48   SER C CB  1 
ATOM   4683 O OG  . SER E 2 36  ? -29.677 22.126  -103.341 1.00 72.73  ? 48   SER C OG  1 
ATOM   4684 N N   . VAL E 2 37  ? -32.489 21.260  -102.676 1.00 73.25  ? 49   VAL C N   1 
ATOM   4685 C CA  . VAL E 2 37  ? -33.127 20.026  -102.221 1.00 76.20  ? 49   VAL C CA  1 
ATOM   4686 C C   . VAL E 2 37  ? -34.497 20.376  -101.649 1.00 74.93  ? 49   VAL C C   1 
ATOM   4687 O O   . VAL E 2 37  ? -34.568 21.096  -100.640 1.00 64.33  ? 49   VAL C O   1 
ATOM   4688 C CB  . VAL E 2 37  ? -32.267 19.282  -101.188 1.00 65.55  ? 49   VAL C CB  1 
ATOM   4689 C CG1 . VAL E 2 37  ? -31.213 18.444  -101.893 1.00 83.71  ? 49   VAL C CG1 1 
ATOM   4690 C CG2 . VAL E 2 37  ? -31.613 20.262  -100.229 1.00 53.50  ? 49   VAL C CG2 1 
ATOM   4691 N N   . PRO E 2 38  ? -35.590 19.896  -102.241 1.00 72.27  ? 50   PRO C N   1 
ATOM   4692 C CA  . PRO E 2 38  ? -36.925 20.295  -101.775 1.00 73.20  ? 50   PRO C CA  1 
ATOM   4693 C C   . PRO E 2 38  ? -37.383 19.519  -100.552 1.00 78.24  ? 50   PRO C C   1 
ATOM   4694 O O   . PRO E 2 38  ? -38.210 20.007  -99.774  1.00 82.91  ? 50   PRO C O   1 
ATOM   4695 C CB  . PRO E 2 38  ? -37.824 20.000  -102.987 1.00 84.01  ? 50   PRO C CB  1 
ATOM   4696 C CG  . PRO E 2 38  ? -36.883 19.597  -104.116 1.00 76.63  ? 50   PRO C CG  1 
ATOM   4697 C CD  . PRO E 2 38  ? -35.662 19.066  -103.451 1.00 66.77  ? 50   PRO C CD  1 
ATOM   4698 N N   . ASP E 2 39  ? -36.862 18.308  -100.375 1.00 81.31  ? 51   ASP C N   1 
ATOM   4699 C CA  . ASP E 2 39  ? -37.245 17.449  -99.264  1.00 70.00  ? 51   ASP C CA  1 
ATOM   4700 C C   . ASP E 2 39  ? -36.449 17.733  -97.997  1.00 56.66  ? 51   ASP C C   1 
ATOM   4701 O O   . ASP E 2 39  ? -36.511 16.939  -97.054  1.00 61.28  ? 51   ASP C O   1 
ATOM   4702 C CB  . ASP E 2 39  ? -37.083 15.976  -99.654  1.00 64.75  ? 51   ASP C CB  1 
ATOM   4703 C CG  . ASP E 2 39  ? -35.710 15.671  -100.222 1.00 73.58  ? 51   ASP C CG  1 
ATOM   4704 O OD1 . ASP E 2 39  ? -35.176 16.513  -100.977 1.00 80.94  ? 51   ASP C OD1 1 
ATOM   4705 O OD2 . ASP E 2 39  ? -35.164 14.590  -99.914  1.00 79.84  ? 51   ASP C OD2 1 
ATOM   4706 N N   . LEU E 2 40  ? -35.716 18.848  -97.951  1.00 53.66  ? 52   LEU C N   1 
ATOM   4707 C CA  . LEU E 2 40  ? -34.839 19.117  -96.816  1.00 46.33  ? 52   LEU C CA  1 
ATOM   4708 C C   . LEU E 2 40  ? -35.632 19.342  -95.532  1.00 52.20  ? 52   LEU C C   1 
ATOM   4709 O O   . LEU E 2 40  ? -35.226 18.878  -94.459  1.00 45.70  ? 52   LEU C O   1 
ATOM   4710 C CB  . LEU E 2 40  ? -33.949 20.322  -97.121  1.00 42.66  ? 52   LEU C CB  1 
ATOM   4711 C CG  . LEU E 2 40  ? -33.137 20.887  -95.953  1.00 41.91  ? 52   LEU C CG  1 
ATOM   4712 C CD1 . LEU E 2 40  ? -31.817 20.140  -95.784  1.00 29.80  ? 52   LEU C CD1 1 
ATOM   4713 C CD2 . LEU E 2 40  ? -32.899 22.380  -96.129  1.00 36.35  ? 52   LEU C CD2 1 
ATOM   4714 N N   . ALA E 2 41  ? -36.764 20.042  -95.620  1.00 59.28  ? 53   ALA C N   1 
ATOM   4715 C CA  . ALA E 2 41  ? -37.532 20.357  -94.417  1.00 51.25  ? 53   ALA C CA  1 
ATOM   4716 C C   . ALA E 2 41  ? -38.086 19.127  -93.702  1.00 40.45  ? 53   ALA C C   1 
ATOM   4717 O O   . ALA E 2 41  ? -38.021 19.095  -92.460  1.00 36.07  ? 53   ALA C O   1 
ATOM   4718 C CB  . ALA E 2 41  ? -38.656 21.341  -94.763  1.00 46.37  ? 53   ALA C CB  1 
ATOM   4719 N N   . PRO E 2 42  ? -38.649 18.116  -94.380  1.00 38.45  ? 54   PRO C N   1 
ATOM   4720 C CA  . PRO E 2 42  ? -38.995 16.882  -93.654  1.00 32.82  ? 54   PRO C CA  1 
ATOM   4721 C C   . PRO E 2 42  ? -37.793 16.211  -93.012  1.00 39.48  ? 54   PRO C C   1 
ATOM   4722 O O   . PRO E 2 42  ? -37.877 15.765  -91.861  1.00 44.40  ? 54   PRO C O   1 
ATOM   4723 C CB  . PRO E 2 42  ? -39.626 16.004  -94.743  1.00 48.47  ? 54   PRO C CB  1 
ATOM   4724 C CG  . PRO E 2 42  ? -40.160 16.973  -95.736  1.00 49.58  ? 54   PRO C CG  1 
ATOM   4725 C CD  . PRO E 2 42  ? -39.166 18.092  -95.761  1.00 49.44  ? 54   PRO C CD  1 
ATOM   4726 N N   . MET E 2 43  ? -36.668 16.128  -93.728  1.00 48.30  ? 55   MET C N   1 
ATOM   4727 C CA  . MET E 2 43  ? -35.460 15.549  -93.152  1.00 43.32  ? 55   MET C CA  1 
ATOM   4728 C C   . MET E 2 43  ? -34.887 16.400  -92.025  1.00 38.30  ? 55   MET C C   1 
ATOM   4729 O O   . MET E 2 43  ? -34.188 15.866  -91.157  1.00 36.02  ? 55   MET C O   1 
ATOM   4730 C CB  . MET E 2 43  ? -34.407 15.328  -94.240  1.00 47.08  ? 55   MET C CB  1 
ATOM   4731 C CG  . MET E 2 43  ? -34.963 14.757  -95.540  1.00 59.06  ? 55   MET C CG  1 
ATOM   4732 S SD  . MET E 2 43  ? -33.699 14.177  -96.696  1.00 57.75  ? 55   MET C SD  1 
ATOM   4733 C CE  . MET E 2 43  ? -32.451 15.450  -96.502  1.00 47.44  ? 55   MET C CE  1 
ATOM   4734 N N   . LEU E 2 44  ? -35.164 17.705  -92.013  1.00 40.74  ? 56   LEU C N   1 
ATOM   4735 C CA  . LEU E 2 44  ? -34.761 18.529  -90.879  1.00 48.01  ? 56   LEU C CA  1 
ATOM   4736 C C   . LEU E 2 44  ? -35.665 18.313  -89.675  1.00 40.76  ? 56   LEU C C   1 
ATOM   4737 O O   . LEU E 2 44  ? -35.194 18.368  -88.533  1.00 42.48  ? 56   LEU C O   1 
ATOM   4738 C CB  . LEU E 2 44  ? -34.770 20.007  -91.264  1.00 48.40  ? 56   LEU C CB  1 
ATOM   4739 C CG  . LEU E 2 44  ? -33.578 20.542  -92.053  1.00 34.86  ? 56   LEU C CG  1 
ATOM   4740 C CD1 . LEU E 2 44  ? -33.866 21.959  -92.519  1.00 47.32  ? 56   LEU C CD1 1 
ATOM   4741 C CD2 . LEU E 2 44  ? -32.317 20.493  -91.210  1.00 31.98  ? 56   LEU C CD2 1 
ATOM   4742 N N   . TRP E 2 45  ? -36.955 18.068  -89.907  1.00 34.96  ? 57   TRP C N   1 
ATOM   4743 C CA  . TRP E 2 45  ? -37.897 17.920  -88.805  1.00 35.62  ? 57   TRP C CA  1 
ATOM   4744 C C   . TRP E 2 45  ? -37.769 16.555  -88.138  1.00 34.90  ? 57   TRP C C   1 
ATOM   4745 O O   . TRP E 2 45  ? -37.609 16.467  -86.915  1.00 31.06  ? 57   TRP C O   1 
ATOM   4746 C CB  . TRP E 2 45  ? -39.329 18.144  -89.301  1.00 37.07  ? 57   TRP C CB  1 
ATOM   4747 C CG  . TRP E 2 45  ? -40.347 18.115  -88.200  1.00 30.02  ? 57   TRP C CG  1 
ATOM   4748 C CD1 . TRP E 2 45  ? -41.206 17.097  -87.904  1.00 25.80  ? 57   TRP C CD1 1 
ATOM   4749 C CD2 . TRP E 2 45  ? -40.603 19.149  -87.239  1.00 38.93  ? 57   TRP C CD2 1 
ATOM   4750 N NE1 . TRP E 2 45  ? -41.983 17.434  -86.820  1.00 29.96  ? 57   TRP C NE1 1 
ATOM   4751 C CE2 . TRP E 2 45  ? -41.631 18.688  -86.394  1.00 40.94  ? 57   TRP C CE2 1 
ATOM   4752 C CE3 . TRP E 2 45  ? -40.065 20.420  -87.015  1.00 39.13  ? 57   TRP C CE3 1 
ATOM   4753 C CZ2 . TRP E 2 45  ? -42.130 19.454  -85.339  1.00 43.45  ? 57   TRP C CZ2 1 
ATOM   4754 C CZ3 . TRP E 2 45  ? -40.562 21.177  -85.967  1.00 30.98  ? 57   TRP C CZ3 1 
ATOM   4755 C CH2 . TRP E 2 45  ? -41.584 20.692  -85.144  1.00 28.18  ? 57   TRP C CH2 1 
ATOM   4756 N N   . HIS E 2 46  ? -37.823 15.481  -88.925  1.00 33.15  ? 58   HIS C N   1 
ATOM   4757 C CA  . HIS E 2 46  ? -37.918 14.129  -88.387  1.00 40.69  ? 58   HIS C CA  1 
ATOM   4758 C C   . HIS E 2 46  ? -36.571 13.505  -88.047  1.00 40.10  ? 58   HIS C C   1 
ATOM   4759 O O   . HIS E 2 46  ? -36.539 12.355  -87.595  1.00 36.44  ? 58   HIS C O   1 
ATOM   4760 C CB  . HIS E 2 46  ? -38.667 13.228  -89.368  1.00 39.52  ? 58   HIS C CB  1 
ATOM   4761 C CG  . HIS E 2 46  ? -40.112 13.579  -89.515  1.00 35.17  ? 58   HIS C CG  1 
ATOM   4762 N ND1 . HIS E 2 46  ? -40.569 14.462  -90.469  1.00 38.49  ? 58   HIS C ND1 1 
ATOM   4763 C CD2 . HIS E 2 46  ? -41.202 13.180  -88.818  1.00 37.25  ? 58   HIS C CD2 1 
ATOM   4764 C CE1 . HIS E 2 46  ? -41.880 14.584  -90.361  1.00 41.53  ? 58   HIS C CE1 1 
ATOM   4765 N NE2 . HIS E 2 46  ? -42.289 13.817  -89.367  1.00 52.62  ? 58   HIS C NE2 1 
ATOM   4766 N N   . SER E 2 47  ? -35.468 14.217  -88.252  1.00 41.61  ? 59   SER C N   1 
ATOM   4767 C CA  . SER E 2 47  ? -34.176 13.750  -87.773  1.00 36.87  ? 59   SER C CA  1 
ATOM   4768 C C   . SER E 2 47  ? -34.017 14.081  -86.294  1.00 33.68  ? 59   SER C C   1 
ATOM   4769 O O   . SER E 2 47  ? -34.636 15.015  -85.774  1.00 45.60  ? 59   SER C O   1 
ATOM   4770 C CB  . SER E 2 47  ? -33.040 14.370  -88.586  1.00 42.68  ? 59   SER C CB  1 
ATOM   4771 O OG  . SER E 2 47  ? -33.165 15.780  -88.652  1.00 36.43  ? 59   SER C OG  1 
ATOM   4772 N N   . PHE E 2 48  ? -33.176 13.303  -85.613  1.00 30.43  ? 60   PHE C N   1 
ATOM   4773 C CA  . PHE E 2 48  ? -33.072 13.417  -84.164  1.00 31.40  ? 60   PHE C CA  1 
ATOM   4774 C C   . PHE E 2 48  ? -32.417 14.732  -83.762  1.00 33.29  ? 60   PHE C C   1 
ATOM   4775 O O   . PHE E 2 48  ? -31.337 15.078  -84.251  1.00 45.47  ? 60   PHE C O   1 
ATOM   4776 C CB  . PHE E 2 48  ? -32.287 12.242  -83.580  1.00 37.27  ? 60   PHE C CB  1 
ATOM   4777 C CG  . PHE E 2 48  ? -32.185 12.278  -82.080  1.00 46.43  ? 60   PHE C CG  1 
ATOM   4778 C CD1 . PHE E 2 48  ? -31.245 13.076  -81.442  1.00 54.04  ? 60   PHE C CD1 1 
ATOM   4779 C CD2 . PHE E 2 48  ? -33.079 11.562  -81.307  1.00 45.43  ? 60   PHE C CD2 1 
ATOM   4780 C CE1 . PHE E 2 48  ? -31.175 13.122  -80.065  1.00 51.24  ? 60   PHE C CE1 1 
ATOM   4781 C CE2 . PHE E 2 48  ? -33.022 11.613  -79.930  1.00 48.84  ? 60   PHE C CE2 1 
ATOM   4782 C CZ  . PHE E 2 48  ? -32.067 12.393  -79.307  1.00 49.13  ? 60   PHE C CZ  1 
ATOM   4783 N N   . GLY E 2 49  ? -33.069 15.451  -82.850  1.00 41.05  ? 61   GLY C N   1 
ATOM   4784 C CA  . GLY E 2 49  ? -32.490 16.618  -82.212  1.00 43.11  ? 61   GLY C CA  1 
ATOM   4785 C C   . GLY E 2 49  ? -32.163 17.785  -83.119  1.00 40.16  ? 61   GLY C C   1 
ATOM   4786 O O   . GLY E 2 49  ? -31.590 18.778  -82.663  1.00 40.43  ? 61   GLY C O   1 
ATOM   4787 N N   . THR E 2 50  ? -32.522 17.686  -84.402  1.00 45.85  ? 62   THR C N   1 
ATOM   4788 C CA  . THR E 2 50  ? -32.196 18.752  -85.344  1.00 36.15  ? 62   THR C CA  1 
ATOM   4789 C C   . THR E 2 50  ? -32.966 20.027  -85.027  1.00 45.70  ? 62   THR C C   1 
ATOM   4790 O O   . THR E 2 50  ? -32.397 21.125  -85.048  1.00 46.51  ? 62   THR C O   1 
ATOM   4791 C CB  . THR E 2 50  ? -32.481 18.293  -86.774  1.00 28.71  ? 62   THR C CB  1 
ATOM   4792 O OG1 . THR E 2 50  ? -31.708 17.122  -87.065  1.00 33.57  ? 62   THR C OG1 1 
ATOM   4793 C CG2 . THR E 2 50  ? -32.129 19.385  -87.768  1.00 39.40  ? 62   THR C CG2 1 
ATOM   4794 N N   . ILE E 2 51  ? -34.259 19.905  -84.725  1.00 42.31  ? 63   ILE C N   1 
ATOM   4795 C CA  . ILE E 2 51  ? -35.036 21.091  -84.389  1.00 35.69  ? 63   ILE C CA  1 
ATOM   4796 C C   . ILE E 2 51  ? -34.742 21.548  -82.962  1.00 37.57  ? 63   ILE C C   1 
ATOM   4797 O O   . ILE E 2 51  ? -34.812 22.747  -82.664  1.00 35.38  ? 63   ILE C O   1 
ATOM   4798 C CB  . ILE E 2 51  ? -36.530 20.817  -84.619  1.00 32.75  ? 63   ILE C CB  1 
ATOM   4799 C CG1 . ILE E 2 51  ? -36.728 20.220  -86.013  1.00 22.52  ? 63   ILE C CG1 1 
ATOM   4800 C CG2 . ILE E 2 51  ? -37.345 22.093  -84.466  1.00 28.55  ? 63   ILE C CG2 1 
ATOM   4801 C CD1 . ILE E 2 51  ? -36.704 21.249  -87.126  1.00 21.38  ? 63   ILE C CD1 1 
ATOM   4802 N N   . ALA E 2 52  ? -34.399 20.619  -82.065  1.00 43.70  ? 64   ALA C N   1 
ATOM   4803 C CA  . ALA E 2 52  ? -33.879 21.019  -80.761  1.00 40.65  ? 64   ALA C CA  1 
ATOM   4804 C C   . ALA E 2 52  ? -32.523 21.700  -80.895  1.00 34.50  ? 64   ALA C C   1 
ATOM   4805 O O   . ALA E 2 52  ? -32.177 22.562  -80.080  1.00 30.77  ? 64   ALA C O   1 
ATOM   4806 C CB  . ALA E 2 52  ? -33.777 19.806  -79.835  1.00 40.09  ? 64   ALA C CB  1 
ATOM   4807 N N   . ALA E 2 53  ? -31.751 21.323  -81.917  1.00 42.21  ? 65   ALA C N   1 
ATOM   4808 C CA  . ALA E 2 53  ? -30.478 21.981  -82.189  1.00 38.02  ? 65   ALA C CA  1 
ATOM   4809 C C   . ALA E 2 53  ? -30.688 23.425  -82.625  1.00 44.08  ? 65   ALA C C   1 
ATOM   4810 O O   . ALA E 2 53  ? -30.067 24.346  -82.080  1.00 43.90  ? 65   ALA C O   1 
ATOM   4811 C CB  . ALA E 2 53  ? -29.712 21.207  -83.261  1.00 40.01  ? 65   ALA C CB  1 
ATOM   4812 N N   . LEU E 2 54  ? -31.557 23.639  -83.618  1.00 46.66  ? 66   LEU C N   1 
ATOM   4813 C CA  . LEU E 2 54  ? -31.829 24.992  -84.096  1.00 37.36  ? 66   LEU C CA  1 
ATOM   4814 C C   . LEU E 2 54  ? -32.437 25.853  -82.995  1.00 50.75  ? 66   LEU C C   1 
ATOM   4815 O O   . LEU E 2 54  ? -32.108 27.040  -82.870  1.00 51.79  ? 66   LEU C O   1 
ATOM   4816 C CB  . LEU E 2 54  ? -32.758 24.940  -85.309  1.00 35.46  ? 66   LEU C CB  1 
ATOM   4817 C CG  . LEU E 2 54  ? -32.278 24.126  -86.512  1.00 26.18  ? 66   LEU C CG  1 
ATOM   4818 C CD1 . LEU E 2 54  ? -33.377 24.007  -87.556  1.00 22.55  ? 66   LEU C CD1 1 
ATOM   4819 C CD2 . LEU E 2 54  ? -31.036 24.753  -87.116  1.00 34.58  ? 66   LEU C CD2 1 
ATOM   4820 N N   . LEU E 2 55  ? -33.335 25.274  -82.194  1.00 49.18  ? 67   LEU C N   1 
ATOM   4821 C CA  . LEU E 2 55  ? -33.878 25.988  -81.043  1.00 42.87  ? 67   LEU C CA  1 
ATOM   4822 C C   . LEU E 2 55  ? -32.773 26.374  -80.071  1.00 50.14  ? 67   LEU C C   1 
ATOM   4823 O O   . LEU E 2 55  ? -32.813 27.451  -79.463  1.00 52.26  ? 67   LEU C O   1 
ATOM   4824 C CB  . LEU E 2 55  ? -34.920 25.122  -80.340  1.00 42.30  ? 67   LEU C CB  1 
ATOM   4825 C CG  . LEU E 2 55  ? -36.366 25.285  -80.793  1.00 45.80  ? 67   LEU C CG  1 
ATOM   4826 C CD1 . LEU E 2 55  ? -37.212 24.197  -80.167  1.00 45.78  ? 67   LEU C CD1 1 
ATOM   4827 C CD2 . LEU E 2 55  ? -36.885 26.664  -80.417  1.00 39.95  ? 67   LEU C CD2 1 
ATOM   4828 N N   . GLN E 2 56  ? -31.779 25.503  -79.914  1.00 46.97  ? 68   GLN C N   1 
ATOM   4829 C CA  . GLN E 2 56  ? -30.669 25.792  -79.018  1.00 47.57  ? 68   GLN C CA  1 
ATOM   4830 C C   . GLN E 2 56  ? -29.836 26.958  -79.535  1.00 53.75  ? 68   GLN C C   1 
ATOM   4831 O O   . GLN E 2 56  ? -29.383 27.801  -78.752  1.00 64.46  ? 68   GLN C O   1 
ATOM   4832 C CB  . GLN E 2 56  ? -29.820 24.538  -78.854  1.00 46.50  ? 68   GLN C CB  1 
ATOM   4833 C CG  . GLN E 2 56  ? -28.750 24.619  -77.805  1.00 41.74  ? 68   GLN C CG  1 
ATOM   4834 C CD  . GLN E 2 56  ? -27.930 23.355  -77.768  1.00 45.76  ? 68   GLN C CD  1 
ATOM   4835 O OE1 . GLN E 2 56  ? -27.456 22.944  -76.716  1.00 55.99  ? 68   GLN C OE1 1 
ATOM   4836 N NE2 . GLN E 2 56  ? -27.766 22.721  -78.924  1.00 50.28  ? 68   GLN C NE2 1 
ATOM   4837 N N   . GLU E 2 57  ? -29.638 27.029  -80.854  1.00 55.48  ? 69   GLU C N   1 
ATOM   4838 C CA  . GLU E 2 57  ? -28.877 28.132  -81.434  1.00 45.56  ? 69   GLU C CA  1 
ATOM   4839 C C   . GLU E 2 57  ? -29.572 29.466  -81.198  1.00 53.83  ? 69   GLU C C   1 
ATOM   4840 O O   . GLU E 2 57  ? -28.913 30.485  -80.957  1.00 58.57  ? 69   GLU C O   1 
ATOM   4841 C CB  . GLU E 2 57  ? -28.670 27.892  -82.929  1.00 42.33  ? 69   GLU C CB  1 
ATOM   4842 C CG  . GLU E 2 57  ? -27.462 27.034  -83.257  1.00 51.23  ? 69   GLU C CG  1 
ATOM   4843 C CD  . GLU E 2 57  ? -26.154 27.775  -83.068  1.00 57.14  ? 69   GLU C CD  1 
ATOM   4844 O OE1 . GLU E 2 57  ? -26.172 29.024  -83.069  1.00 67.77  ? 69   GLU C OE1 1 
ATOM   4845 O OE2 . GLU E 2 57  ? -25.108 27.107  -82.921  1.00 50.32  ? 69   GLU C OE2 1 
ATOM   4846 N N   . ILE E 2 58  ? -30.906 29.480  -81.266  1.00 50.50  ? 70   ILE C N   1 
ATOM   4847 C CA  . ILE E 2 58  ? -31.660 30.701  -80.997  1.00 36.81  ? 70   ILE C CA  1 
ATOM   4848 C C   . ILE E 2 58  ? -31.446 31.146  -79.557  1.00 49.47  ? 70   ILE C C   1 
ATOM   4849 O O   . ILE E 2 58  ? -31.128 32.310  -79.285  1.00 60.40  ? 70   ILE C O   1 
ATOM   4850 C CB  . ILE E 2 58  ? -33.155 30.481  -81.290  1.00 32.92  ? 70   ILE C CB  1 
ATOM   4851 C CG1 . ILE E 2 58  ? -33.390 30.208  -82.776  1.00 34.46  ? 70   ILE C CG1 1 
ATOM   4852 C CG2 . ILE E 2 58  ? -33.973 31.680  -80.823  1.00 33.14  ? 70   ILE C CG2 1 
ATOM   4853 C CD1 . ILE E 2 58  ? -34.858 30.189  -83.155  1.00 38.60  ? 70   ILE C CD1 1 
ATOM   4854 N N   . VAL E 2 59  ? -31.608 30.217  -78.613  1.00 52.73  ? 71   VAL C N   1 
ATOM   4855 C CA  . VAL E 2 59  ? -31.645 30.579  -77.200  1.00 60.74  ? 71   VAL C CA  1 
ATOM   4856 C C   . VAL E 2 59  ? -30.272 31.036  -76.720  1.00 59.09  ? 71   VAL C C   1 
ATOM   4857 O O   . VAL E 2 59  ? -30.162 31.952  -75.896  1.00 52.10  ? 71   VAL C O   1 
ATOM   4858 C CB  . VAL E 2 59  ? -32.183 29.396  -76.373  1.00 51.80  ? 71   VAL C CB  1 
ATOM   4859 C CG1 . VAL E 2 59  ? -31.945 29.617  -74.888  1.00 48.47  ? 71   VAL C CG1 1 
ATOM   4860 C CG2 . VAL E 2 59  ? -33.661 29.193  -76.661  1.00 41.88  ? 71   VAL C CG2 1 
ATOM   4861 N N   . ASN E 2 60  ? -29.206 30.427  -77.243  1.00 64.81  ? 72   ASN C N   1 
ATOM   4862 C CA  . ASN E 2 60  ? -27.850 30.786  -76.839  1.00 63.87  ? 72   ASN C CA  1 
ATOM   4863 C C   . ASN E 2 60  ? -27.487 32.226  -77.187  1.00 60.56  ? 72   ASN C C   1 
ATOM   4864 O O   . ASN E 2 60  ? -26.451 32.714  -76.720  1.00 71.25  ? 72   ASN C O   1 
ATOM   4865 C CB  . ASN E 2 60  ? -26.838 29.827  -77.477  1.00 47.94  ? 72   ASN C CB  1 
ATOM   4866 C CG  . ASN E 2 60  ? -26.913 28.414  -76.904  1.00 67.10  ? 72   ASN C CG  1 
ATOM   4867 O OD1 . ASN E 2 60  ? -25.894 27.835  -76.528  1.00 70.44  ? 72   ASN C OD1 1 
ATOM   4868 N ND2 . ASN E 2 60  ? -28.118 27.857  -76.835  1.00 69.65  ? 72   ASN C ND2 1 
ATOM   4869 N N   . ILE E 2 61  ? -28.305 32.909  -77.990  1.00 53.34  ? 73   ILE C N   1 
ATOM   4870 C CA  . ILE E 2 61  ? -28.050 34.298  -78.359  1.00 54.78  ? 73   ILE C CA  1 
ATOM   4871 C C   . ILE E 2 61  ? -28.879 35.278  -77.527  1.00 56.99  ? 73   ILE C C   1 
ATOM   4872 O O   . ILE E 2 61  ? -28.485 36.448  -77.398  1.00 64.19  ? 73   ILE C O   1 
ATOM   4873 C CB  . ILE E 2 61  ? -28.271 34.499  -79.881  1.00 56.65  ? 73   ILE C CB  1 
ATOM   4874 C CG1 . ILE E 2 61  ? -27.032 34.080  -80.698  1.00 75.30  ? 73   ILE C CG1 1 
ATOM   4875 C CG2 . ILE E 2 61  ? -28.692 35.921  -80.246  1.00 31.18  ? 73   ILE C CG2 1 
ATOM   4876 C CD1 . ILE E 2 61  ? -26.347 32.778  -80.311  1.00 74.44  ? 73   ILE C CD1 1 
ATOM   4877 N N   . TYR E 2 62  ? -29.978 34.819  -76.910  1.00 56.11  ? 74   TYR C N   1 
ATOM   4878 C CA  . TYR E 2 62  ? -30.758 35.584  -75.936  1.00 61.29  ? 74   TYR C CA  1 
ATOM   4879 C C   . TYR E 2 62  ? -29.893 36.360  -74.940  1.00 54.65  ? 74   TYR C C   1 
ATOM   4880 O O   . TYR E 2 62  ? -30.227 37.508  -74.618  1.00 53.24  ? 74   TYR C O   1 
ATOM   4881 C CB  . TYR E 2 62  ? -31.715 34.666  -75.164  1.00 54.98  ? 74   TYR C CB  1 
ATOM   4882 C CG  . TYR E 2 62  ? -32.893 34.144  -75.958  1.00 55.15  ? 74   TYR C CG  1 
ATOM   4883 C CD1 . TYR E 2 62  ? -33.317 34.783  -77.115  1.00 59.48  ? 74   TYR C CD1 1 
ATOM   4884 C CD2 . TYR E 2 62  ? -33.593 33.022  -75.536  1.00 53.89  ? 74   TYR C CD2 1 
ATOM   4885 C CE1 . TYR E 2 62  ? -34.399 34.309  -77.837  1.00 59.43  ? 74   TYR C CE1 1 
ATOM   4886 C CE2 . TYR E 2 62  ? -34.674 32.542  -76.249  1.00 58.33  ? 74   TYR C CE2 1 
ATOM   4887 C CZ  . TYR E 2 62  ? -35.072 33.189  -77.398  1.00 57.14  ? 74   TYR C CZ  1 
ATOM   4888 O OH  . TYR E 2 62  ? -36.146 32.713  -78.112  1.00 56.62  ? 74   TYR C OH  1 
ATOM   4889 N N   . PRO E 2 63  ? -28.800 35.787  -74.409  1.00 53.92  ? 75   PRO C N   1 
ATOM   4890 C CA  . PRO E 2 63  ? -27.955 36.573  -73.492  1.00 53.16  ? 75   PRO C CA  1 
ATOM   4891 C C   . PRO E 2 63  ? -27.390 37.843  -74.101  1.00 61.54  ? 75   PRO C C   1 
ATOM   4892 O O   . PRO E 2 63  ? -27.199 38.831  -73.381  1.00 69.30  ? 75   PRO C O   1 
ATOM   4893 C CB  . PRO E 2 63  ? -26.839 35.586  -73.125  1.00 48.31  ? 75   PRO C CB  1 
ATOM   4894 C CG  . PRO E 2 63  ? -27.502 34.270  -73.194  1.00 54.69  ? 75   PRO C CG  1 
ATOM   4895 C CD  . PRO E 2 63  ? -28.390 34.367  -74.403  1.00 58.02  ? 75   PRO C CD  1 
ATOM   4896 N N   . SER E 2 64  ? -27.117 37.853  -75.405  1.00 67.08  ? 76   SER C N   1 
ATOM   4897 C CA  . SER E 2 64  ? -26.480 39.001  -76.037  1.00 64.27  ? 76   SER C CA  1 
ATOM   4898 C C   . SER E 2 64  ? -27.448 40.137  -76.351  1.00 63.18  ? 76   SER C C   1 
ATOM   4899 O O   . SER E 2 64  ? -26.993 41.223  -76.722  1.00 82.65  ? 76   SER C O   1 
ATOM   4900 C CB  . SER E 2 64  ? -25.777 38.567  -77.327  1.00 54.04  ? 76   SER C CB  1 
ATOM   4901 O OG  . SER E 2 64  ? -24.532 37.946  -77.054  1.00 52.41  ? 76   SER C OG  1 
ATOM   4902 N N   . ILE E 2 65  ? -28.757 39.930  -76.212  1.00 53.20  ? 77   ILE C N   1 
ATOM   4903 C CA  . ILE E 2 65  ? -29.711 40.934  -76.675  1.00 55.07  ? 77   ILE C CA  1 
ATOM   4904 C C   . ILE E 2 65  ? -29.931 42.015  -75.626  1.00 71.10  ? 77   ILE C C   1 
ATOM   4905 O O   . ILE E 2 65  ? -29.850 43.212  -75.926  1.00 88.38  ? 77   ILE C O   1 
ATOM   4906 C CB  . ILE E 2 65  ? -31.039 40.273  -77.081  1.00 63.49  ? 77   ILE C CB  1 
ATOM   4907 C CG1 . ILE E 2 65  ? -30.899 39.617  -78.453  1.00 74.14  ? 77   ILE C CG1 1 
ATOM   4908 C CG2 . ILE E 2 65  ? -32.172 41.294  -77.070  1.00 61.87  ? 77   ILE C CG2 1 
ATOM   4909 C CD1 . ILE E 2 65  ? -31.905 38.536  -78.698  1.00 79.25  ? 77   ILE C CD1 1 
ATOM   4910 N N   . ASN E 2 66  ? -30.228 41.620  -74.392  1.00 84.85  ? 78   ASN C N   1 
ATOM   4911 C CA  . ASN E 2 66  ? -30.669 42.589  -73.393  1.00 89.67  ? 78   ASN C CA  1 
ATOM   4912 C C   . ASN E 2 66  ? -29.537 43.547  -73.018  1.00 91.28  ? 78   ASN C C   1 
ATOM   4913 O O   . ASN E 2 66  ? -29.787 44.750  -72.864  1.00 78.05  ? 78   ASN C O   1 
ATOM   4914 C CB  . ASN E 2 66  ? -31.239 41.862  -72.175  1.00 83.35  ? 78   ASN C CB  1 
ATOM   4915 C CG  . ASN E 2 66  ? -32.753 41.793  -72.205  1.00 97.08  ? 78   ASN C CG  1 
ATOM   4916 O OD1 . ASN E 2 66  ? -33.408 42.601  -72.866  1.00 87.41  ? 78   ASN C OD1 1 
ATOM   4917 N ND2 . ASN E 2 66  ? -33.316 40.814  -71.509  1.00 103.36 ? 78   ASN C ND2 1 
ATOM   4918 N N   . PRO E 2 67  ? -28.299 43.080  -72.849  1.00 93.32  ? 79   PRO C N   1 
ATOM   4919 C CA  . PRO E 2 67  ? -27.148 43.978  -73.015  1.00 84.83  ? 79   PRO C CA  1 
ATOM   4920 C C   . PRO E 2 67  ? -26.594 43.864  -74.424  1.00 90.32  ? 79   PRO C C   1 
ATOM   4921 O O   . PRO E 2 67  ? -25.914 42.878  -74.748  1.00 93.80  ? 79   PRO C O   1 
ATOM   4922 C CB  . PRO E 2 67  ? -26.136 43.463  -71.975  1.00 50.43  ? 79   PRO C CB  1 
ATOM   4923 C CG  . PRO E 2 67  ? -26.866 42.386  -71.192  1.00 59.10  ? 79   PRO C CG  1 
ATOM   4924 C CD  . PRO E 2 67  ? -27.888 41.857  -72.141  1.00 69.78  ? 79   PRO C CD  1 
ATOM   4925 N N   . PRO E 2 68  ? -26.849 44.861  -75.295  1.00 82.04  ? 80   PRO C N   1 
ATOM   4926 C CA  . PRO E 2 68  ? -26.645 44.655  -76.742  1.00 65.43  ? 80   PRO C CA  1 
ATOM   4927 C C   . PRO E 2 68  ? -25.210 44.334  -77.148  1.00 68.05  ? 80   PRO C C   1 
ATOM   4928 O O   . PRO E 2 68  ? -24.449 45.222  -77.547  1.00 73.44  ? 80   PRO C O   1 
ATOM   4929 C CB  . PRO E 2 68  ? -27.115 45.987  -77.350  1.00 51.52  ? 80   PRO C CB  1 
ATOM   4930 C CG  . PRO E 2 68  ? -27.902 46.673  -76.240  1.00 63.30  ? 80   PRO C CG  1 
ATOM   4931 C CD  . PRO E 2 68  ? -27.206 46.257  -74.992  1.00 72.17  ? 80   PRO C CD  1 
ATOM   4932 N N   . THR E 2 69  ? -24.841 43.053  -77.081  1.00 69.08  ? 81   THR C N   1 
ATOM   4933 C CA  . THR E 2 69  ? -23.471 42.608  -77.321  1.00 64.18  ? 81   THR C CA  1 
ATOM   4934 C C   . THR E 2 69  ? -23.354 41.695  -78.539  1.00 68.72  ? 81   THR C C   1 
ATOM   4935 O O   . THR E 2 69  ? -22.305 41.070  -78.736  1.00 80.25  ? 81   THR C O   1 
ATOM   4936 C CB  . THR E 2 69  ? -22.929 41.885  -76.082  1.00 69.83  ? 81   THR C CB  1 
ATOM   4937 O OG1 . THR E 2 69  ? -23.461 42.496  -74.901  1.00 86.51  ? 81   THR C OG1 1 
ATOM   4938 C CG2 . THR E 2 69  ? -21.405 41.987  -76.020  1.00 83.01  ? 81   THR C CG2 1 
ATOM   4939 N N   . LEU E 2 70  ? -24.397 41.603  -79.362  1.00 65.79  ? 82   LEU C N   1 
ATOM   4940 C CA  . LEU E 2 70  ? -24.383 40.680  -80.490  1.00 67.60  ? 82   LEU C CA  1 
ATOM   4941 C C   . LEU E 2 70  ? -23.285 41.044  -81.480  1.00 70.92  ? 82   LEU C C   1 
ATOM   4942 O O   . LEU E 2 70  ? -23.155 42.204  -81.883  1.00 83.24  ? 82   LEU C O   1 
ATOM   4943 C CB  . LEU E 2 70  ? -25.737 40.688  -81.196  1.00 50.30  ? 82   LEU C CB  1 
ATOM   4944 C CG  . LEU E 2 70  ? -25.996 39.537  -82.168  1.00 51.99  ? 82   LEU C CG  1 
ATOM   4945 C CD1 . LEU E 2 70  ? -26.113 38.224  -81.415  1.00 50.42  ? 82   LEU C CD1 1 
ATOM   4946 C CD2 . LEU E 2 70  ? -27.242 39.799  -82.996  1.00 49.93  ? 82   LEU C CD2 1 
ATOM   4947 N N   . THR E 2 71  ? -22.493 40.051  -81.870  1.00 53.13  ? 83   THR C N   1 
ATOM   4948 C CA  . THR E 2 71  ? -21.515 40.222  -82.932  1.00 59.02  ? 83   THR C CA  1 
ATOM   4949 C C   . THR E 2 71  ? -22.081 39.697  -84.247  1.00 66.38  ? 83   THR C C   1 
ATOM   4950 O O   . THR E 2 71  ? -22.997 38.870  -84.272  1.00 74.51  ? 83   THR C O   1 
ATOM   4951 C CB  . THR E 2 71  ? -20.193 39.517  -82.595  1.00 55.30  ? 83   THR C CB  1 
ATOM   4952 O OG1 . THR E 2 71  ? -19.246 39.742  -83.647  1.00 83.94  ? 83   THR C OG1 1 
ATOM   4953 C CG2 . THR E 2 71  ? -20.390 38.027  -82.422  1.00 50.50  ? 83   THR C CG2 1 
ATOM   4954 N N   . ALA E 2 72  ? -21.535 40.214  -85.352  1.00 60.46  ? 84   ALA C N   1 
ATOM   4955 C CA  . ALA E 2 72  ? -22.009 39.806  -86.671  1.00 66.58  ? 84   ALA C CA  1 
ATOM   4956 C C   . ALA E 2 72  ? -21.783 38.321  -86.912  1.00 67.11  ? 84   ALA C C   1 
ATOM   4957 O O   . ALA E 2 72  ? -22.559 37.683  -87.634  1.00 71.76  ? 84   ALA C O   1 
ATOM   4958 C CB  . ALA E 2 72  ? -21.321 40.631  -87.758  1.00 89.02  ? 84   ALA C CB  1 
ATOM   4959 N N   . HIS E 2 73  ? -20.727 37.756  -86.324  1.00 60.23  ? 85   HIS C N   1 
ATOM   4960 C CA  . HIS E 2 73  ? -20.527 36.314  -86.401  1.00 62.75  ? 85   HIS C CA  1 
ATOM   4961 C C   . HIS E 2 73  ? -21.641 35.574  -85.670  1.00 73.13  ? 85   HIS C C   1 
ATOM   4962 O O   . HIS E 2 73  ? -22.147 34.557  -86.160  1.00 71.52  ? 85   HIS C O   1 
ATOM   4963 C CB  . HIS E 2 73  ? -19.155 35.953  -85.834  1.00 74.99  ? 85   HIS C CB  1 
ATOM   4964 C CG  . HIS E 2 73  ? -19.018 34.516  -85.442  1.00 83.29  ? 85   HIS C CG  1 
ATOM   4965 N ND1 . HIS E 2 73  ? -19.001 34.103  -84.127  1.00 91.69  ? 85   HIS C ND1 1 
ATOM   4966 C CD2 . HIS E 2 73  ? -18.882 33.396  -86.190  1.00 65.84  ? 85   HIS C CD2 1 
ATOM   4967 C CE1 . HIS E 2 73  ? -18.866 32.790  -84.083  1.00 94.38  ? 85   HIS C CE1 1 
ATOM   4968 N NE2 . HIS E 2 73  ? -18.792 32.336  -85.321  1.00 86.31  ? 85   HIS C NE2 1 
ATOM   4969 N N   . GLN E 2 74  ? -22.043 36.080  -84.499  1.00 77.52  ? 86   GLN C N   1 
ATOM   4970 C CA  . GLN E 2 74  ? -23.211 35.539  -83.808  1.00 61.48  ? 86   GLN C CA  1 
ATOM   4971 C C   . GLN E 2 74  ? -24.475 35.735  -84.632  1.00 57.18  ? 86   GLN C C   1 
ATOM   4972 O O   . GLN E 2 74  ? -25.295 34.816  -84.757  1.00 68.13  ? 86   GLN C O   1 
ATOM   4973 C CB  . GLN E 2 74  ? -23.380 36.219  -82.450  1.00 55.69  ? 86   GLN C CB  1 
ATOM   4974 C CG  . GLN E 2 74  ? -22.689 35.562  -81.279  1.00 47.34  ? 86   GLN C CG  1 
ATOM   4975 C CD  . GLN E 2 74  ? -22.722 36.452  -80.049  1.00 60.68  ? 86   GLN C CD  1 
ATOM   4976 O OE1 . GLN E 2 74  ? -21.711 37.038  -79.665  1.00 79.77  ? 86   GLN C OE1 1 
ATOM   4977 N NE2 . GLN E 2 74  ? -23.895 36.572  -79.437  1.00 60.98  ? 86   GLN C NE2 1 
ATOM   4978 N N   . SER E 2 75  ? -24.655 36.935  -85.190  1.00 51.90  ? 87   SER C N   1 
ATOM   4979 C CA  . SER E 2 75  ? -25.884 37.253  -85.910  1.00 49.99  ? 87   SER C CA  1 
ATOM   4980 C C   . SER E 2 75  ? -26.046 36.386  -87.151  1.00 59.73  ? 87   SER C C   1 
ATOM   4981 O O   . SER E 2 75  ? -27.161 35.964  -87.477  1.00 72.41  ? 87   SER C O   1 
ATOM   4982 C CB  . SER E 2 75  ? -25.902 38.733  -86.286  1.00 56.56  ? 87   SER C CB  1 
ATOM   4983 O OG  . SER E 2 75  ? -27.093 39.062  -86.980  1.00 54.46  ? 87   SER C OG  1 
ATOM   4984 N N   . ASN E 2 76  ? -24.952 36.115  -87.863  1.00 63.73  ? 88   ASN C N   1 
ATOM   4985 C CA  . ASN E 2 76  ? -25.039 35.247  -89.029  1.00 47.61  ? 88   ASN C CA  1 
ATOM   4986 C C   . ASN E 2 76  ? -25.183 33.780  -88.652  1.00 62.22  ? 88   ASN C C   1 
ATOM   4987 O O   . ASN E 2 76  ? -25.643 32.986  -89.479  1.00 75.28  ? 88   ASN C O   1 
ATOM   4988 C CB  . ASN E 2 76  ? -23.813 35.430  -89.925  1.00 46.31  ? 88   ASN C CB  1 
ATOM   4989 C CG  . ASN E 2 76  ? -24.154 35.341  -91.401  1.00 62.02  ? 88   ASN C CG  1 
ATOM   4990 O OD1 . ASN E 2 76  ? -25.038 34.583  -91.804  1.00 56.88  ? 88   ASN C OD1 1 
ATOM   4991 N ND2 . ASN E 2 76  ? -23.451 36.116  -92.217  1.00 78.43  ? 88   ASN C ND2 1 
ATOM   4992 N N   . ARG E 2 77  ? -24.808 33.403  -87.427  1.00 65.93  ? 89   ARG C N   1 
ATOM   4993 C CA  . ARG E 2 77  ? -24.965 32.013  -87.011  1.00 59.53  ? 89   ARG C CA  1 
ATOM   4994 C C   . ARG E 2 77  ? -26.429 31.675  -86.754  1.00 59.33  ? 89   ARG C C   1 
ATOM   4995 O O   . ARG E 2 77  ? -26.895 30.593  -87.131  1.00 61.81  ? 89   ARG C O   1 
ATOM   4996 C CB  . ARG E 2 77  ? -24.123 31.730  -85.766  1.00 53.78  ? 89   ARG C CB  1 
ATOM   4997 C CG  . ARG E 2 77  ? -23.590 30.306  -85.706  1.00 50.83  ? 89   ARG C CG  1 
ATOM   4998 C CD  . ARG E 2 77  ? -22.765 30.057  -84.453  1.00 47.28  ? 89   ARG C CD  1 
ATOM   4999 N NE  . ARG E 2 77  ? -22.828 28.659  -84.042  1.00 50.09  ? 89   ARG C NE  1 
ATOM   5000 C CZ  . ARG E 2 77  ? -21.875 28.030  -83.368  1.00 63.02  ? 89   ARG C CZ  1 
ATOM   5001 N NH1 . ARG E 2 77  ? -20.762 28.648  -83.005  1.00 82.71  ? 89   ARG C NH1 1 
ATOM   5002 N NH2 . ARG E 2 77  ? -22.040 26.749  -83.052  1.00 59.36  ? 89   ARG C NH2 1 
ATOM   5003 N N   . VAL E 2 78  ? -27.170 32.584  -86.117  1.00 52.93  ? 90   VAL C N   1 
ATOM   5004 C CA  . VAL E 2 78  ? -28.585 32.330  -85.865  1.00 46.25  ? 90   VAL C CA  1 
ATOM   5005 C C   . VAL E 2 78  ? -29.410 32.534  -87.128  1.00 52.17  ? 90   VAL C C   1 
ATOM   5006 O O   . VAL E 2 78  ? -30.340 31.768  -87.399  1.00 63.35  ? 90   VAL C O   1 
ATOM   5007 C CB  . VAL E 2 78  ? -29.097 33.201  -84.705  1.00 34.24  ? 90   VAL C CB  1 
ATOM   5008 C CG1 . VAL E 2 78  ? -28.545 32.683  -83.403  1.00 49.77  ? 90   VAL C CG1 1 
ATOM   5009 C CG2 . VAL E 2 78  ? -28.709 34.660  -84.906  1.00 38.27  ? 90   VAL C CG2 1 
ATOM   5010 N N   . CYS E 2 79  ? -29.088 33.557  -87.924  1.00 48.53  ? 91   CYS C N   1 
ATOM   5011 C CA  . CYS E 2 79  ? -29.789 33.752  -89.188  1.00 46.55  ? 91   CYS C CA  1 
ATOM   5012 C C   . CYS E 2 79  ? -29.502 32.629  -90.174  1.00 51.09  ? 91   CYS C C   1 
ATOM   5013 O O   . CYS E 2 79  ? -30.290 32.420  -91.104  1.00 48.43  ? 91   CYS C O   1 
ATOM   5014 C CB  . CYS E 2 79  ? -29.418 35.104  -89.793  1.00 53.29  ? 91   CYS C CB  1 
ATOM   5015 S SG  . CYS E 2 79  ? -30.116 36.505  -88.890  1.00 52.80  ? 91   CYS C SG  1 
ATOM   5016 N N   . ASN E 2 80  ? -28.390 31.914  -89.996  1.00 57.00  ? 92   ASN C N   1 
ATOM   5017 C CA  . ASN E 2 80  ? -28.195 30.651  -90.698  1.00 53.01  ? 92   ASN C CA  1 
ATOM   5018 C C   . ASN E 2 80  ? -29.219 29.624  -90.232  1.00 49.50  ? 92   ASN C C   1 
ATOM   5019 O O   . ASN E 2 80  ? -30.000 29.094  -91.030  1.00 54.91  ? 92   ASN C O   1 
ATOM   5020 C CB  . ASN E 2 80  ? -26.772 30.138  -90.465  1.00 55.69  ? 92   ASN C CB  1 
ATOM   5021 C CG  . ASN E 2 80  ? -25.898 30.253  -91.699  1.00 62.07  ? 92   ASN C CG  1 
ATOM   5022 O OD1 . ASN E 2 80  ? -26.249 29.764  -92.771  1.00 70.16  ? 92   ASN C OD1 1 
ATOM   5023 N ND2 . ASN E 2 80  ? -24.746 30.897  -91.550  1.00 49.04  ? 92   ASN C ND2 1 
ATOM   5024 N N   . ALA E 2 81  ? -29.242 29.354  -88.922  1.00 50.99  ? 93   ALA C N   1 
ATOM   5025 C CA  . ALA E 2 81  ? -30.180 28.386  -88.361  1.00 42.15  ? 93   ALA C CA  1 
ATOM   5026 C C   . ALA E 2 81  ? -31.629 28.820  -88.567  1.00 45.44  ? 93   ALA C C   1 
ATOM   5027 O O   . ALA E 2 81  ? -32.511 27.978  -88.773  1.00 51.69  ? 93   ALA C O   1 
ATOM   5028 C CB  . ALA E 2 81  ? -29.889 28.183  -86.875  1.00 30.30  ? 93   ALA C CB  1 
ATOM   5029 N N   . LEU E 2 82  ? -31.897 30.128  -88.502  1.00 45.25  ? 94   LEU C N   1 
ATOM   5030 C CA  . LEU E 2 82  ? -33.246 30.623  -88.768  1.00 26.89  ? 94   LEU C CA  1 
ATOM   5031 C C   . LEU E 2 82  ? -33.684 30.309  -90.192  1.00 34.44  ? 94   LEU C C   1 
ATOM   5032 O O   . LEU E 2 82  ? -34.873 30.073  -90.437  1.00 37.98  ? 94   LEU C O   1 
ATOM   5033 C CB  . LEU E 2 82  ? -33.315 32.132  -88.519  1.00 41.73  ? 94   LEU C CB  1 
ATOM   5034 C CG  . LEU E 2 82  ? -33.368 32.622  -87.070  1.00 34.64  ? 94   LEU C CG  1 
ATOM   5035 C CD1 . LEU E 2 82  ? -34.053 33.976  -86.971  1.00 43.45  ? 94   LEU C CD1 1 
ATOM   5036 C CD2 . LEU E 2 82  ? -34.081 31.608  -86.211  1.00 35.77  ? 94   LEU C CD2 1 
ATOM   5037 N N   . ALA E 2 83  ? -32.742 30.298  -91.140  1.00 39.37  ? 95   ALA C N   1 
ATOM   5038 C CA  . ALA E 2 83  ? -33.085 30.030  -92.532  1.00 31.59  ? 95   ALA C CA  1 
ATOM   5039 C C   . ALA E 2 83  ? -33.511 28.583  -92.744  1.00 41.89  ? 95   ALA C C   1 
ATOM   5040 O O   . ALA E 2 83  ? -34.305 28.302  -93.649  1.00 53.03  ? 95   ALA C O   1 
ATOM   5041 C CB  . ALA E 2 83  ? -31.904 30.372  -93.439  1.00 43.21  ? 95   ALA C CB  1 
ATOM   5042 N N   . LEU E 2 84  ? -32.991 27.651  -91.938  1.00 45.56  ? 96   LEU C N   1 
ATOM   5043 C CA  . LEU E 2 84  ? -33.462 26.273  -92.024  1.00 47.74  ? 96   LEU C CA  1 
ATOM   5044 C C   . LEU E 2 84  ? -34.798 26.094  -91.311  1.00 43.64  ? 96   LEU C C   1 
ATOM   5045 O O   . LEU E 2 84  ? -35.638 25.303  -91.755  1.00 43.81  ? 96   LEU C O   1 
ATOM   5046 C CB  . LEU E 2 84  ? -32.423 25.306  -91.454  1.00 43.96  ? 96   LEU C CB  1 
ATOM   5047 C CG  . LEU E 2 84  ? -31.025 25.284  -92.077  1.00 38.40  ? 96   LEU C CG  1 
ATOM   5048 C CD1 . LEU E 2 84  ? -30.040 26.044  -91.218  1.00 35.84  ? 96   LEU C CD1 1 
ATOM   5049 C CD2 . LEU E 2 84  ? -30.565 23.854  -92.279  1.00 38.67  ? 96   LEU C CD2 1 
ATOM   5050 N N   . LEU E 2 85  ? -35.009 26.805  -90.199  1.00 38.16  ? 97   LEU C N   1 
ATOM   5051 C CA  . LEU E 2 85  ? -36.323 26.800  -89.568  1.00 29.79  ? 97   LEU C CA  1 
ATOM   5052 C C   . LEU E 2 85  ? -37.373 27.418  -90.482  1.00 47.14  ? 97   LEU C C   1 
ATOM   5053 O O   . LEU E 2 85  ? -38.530 26.982  -90.480  1.00 64.75  ? 97   LEU C O   1 
ATOM   5054 C CB  . LEU E 2 85  ? -36.274 27.539  -88.232  1.00 25.22  ? 97   LEU C CB  1 
ATOM   5055 C CG  . LEU E 2 85  ? -35.791 26.727  -87.028  1.00 27.34  ? 97   LEU C CG  1 
ATOM   5056 C CD1 . LEU E 2 85  ? -35.500 27.632  -85.835  1.00 25.97  ? 97   LEU C CD1 1 
ATOM   5057 C CD2 . LEU E 2 85  ? -36.806 25.656  -86.662  1.00 26.87  ? 97   LEU C CD2 1 
ATOM   5058 N N   . GLN E 2 86  ? -36.991 28.431  -91.266  1.00 39.28  ? 98   GLN C N   1 
ATOM   5059 C CA  . GLN E 2 86  ? -37.896 28.973  -92.274  1.00 37.37  ? 98   GLN C CA  1 
ATOM   5060 C C   . GLN E 2 86  ? -38.237 27.917  -93.319  1.00 44.31  ? 98   GLN C C   1 
ATOM   5061 O O   . GLN E 2 86  ? -39.398 27.789  -93.725  1.00 51.54  ? 98   GLN C O   1 
ATOM   5062 C CB  . GLN E 2 86  ? -37.265 30.217  -92.917  1.00 46.27  ? 98   GLN C CB  1 
ATOM   5063 C CG  . GLN E 2 86  ? -37.503 30.430  -94.422  1.00 52.23  ? 98   GLN C CG  1 
ATOM   5064 C CD  . GLN E 2 86  ? -38.967 30.548  -94.825  1.00 55.30  ? 98   GLN C CD  1 
ATOM   5065 O OE1 . GLN E 2 86  ? -39.853 30.712  -93.984  1.00 70.68  ? 98   GLN C OE1 1 
ATOM   5066 N NE2 . GLN E 2 86  ? -39.225 30.439  -96.123  1.00 53.87  ? 98   GLN C NE2 1 
ATOM   5067 N N   . CYS E 2 87  ? -37.242 27.136  -93.754  1.00 45.71  ? 99   CYS C N   1 
ATOM   5068 C CA  . CYS E 2 87  ? -37.509 26.059  -94.702  1.00 49.09  ? 99   CYS C CA  1 
ATOM   5069 C C   . CYS E 2 87  ? -38.508 25.053  -94.139  1.00 58.38  ? 99   CYS C C   1 
ATOM   5070 O O   . CYS E 2 87  ? -39.310 24.489  -94.893  1.00 60.81  ? 99   CYS C O   1 
ATOM   5071 C CB  . CYS E 2 87  ? -36.203 25.360  -95.090  1.00 36.08  ? 99   CYS C CB  1 
ATOM   5072 S SG  . CYS E 2 87  ? -36.374 24.107  -96.391  1.00 79.11  ? 99   CYS C SG  1 
ATOM   5073 N N   . VAL E 2 88  ? -38.484 24.826  -92.822  1.00 58.55  ? 100  VAL C N   1 
ATOM   5074 C CA  . VAL E 2 88  ? -39.462 23.937  -92.200  1.00 42.80  ? 100  VAL C CA  1 
ATOM   5075 C C   . VAL E 2 88  ? -40.848 24.569  -92.228  1.00 46.31  ? 100  VAL C C   1 
ATOM   5076 O O   . VAL E 2 88  ? -41.853 23.887  -92.464  1.00 54.94  ? 100  VAL C O   1 
ATOM   5077 C CB  . VAL E 2 88  ? -39.025 23.585  -90.765  1.00 38.26  ? 100  VAL C CB  1 
ATOM   5078 C CG1 . VAL E 2 88  ? -40.059 22.692  -90.088  1.00 43.67  ? 100  VAL C CG1 1 
ATOM   5079 C CG2 . VAL E 2 88  ? -37.658 22.911  -90.773  1.00 42.70  ? 100  VAL C CG2 1 
ATOM   5080 N N   . ALA E 2 89  ? -40.926 25.883  -91.996  1.00 39.23  ? 101  ALA C N   1 
ATOM   5081 C CA  . ALA E 2 89  ? -42.206 26.580  -92.041  1.00 36.55  ? 101  ALA C CA  1 
ATOM   5082 C C   . ALA E 2 89  ? -42.740 26.739  -93.460  1.00 48.60  ? 101  ALA C C   1 
ATOM   5083 O O   . ALA E 2 89  ? -43.954 26.878  -93.638  1.00 54.92  ? 101  ALA C O   1 
ATOM   5084 C CB  . ALA E 2 89  ? -42.082 27.953  -91.378  1.00 36.42  ? 101  ALA C CB  1 
ATOM   5085 N N   . SER E 2 90  ? -41.869 26.721  -94.471  1.00 52.18  ? 102  SER C N   1 
ATOM   5086 C CA  . SER E 2 90  ? -42.328 26.857  -95.850  1.00 36.30  ? 102  SER C CA  1 
ATOM   5087 C C   . SER E 2 90  ? -42.917 25.559  -96.388  1.00 47.66  ? 102  SER C C   1 
ATOM   5088 O O   . SER E 2 90  ? -43.873 25.599  -97.171  1.00 50.42  ? 102  SER C O   1 
ATOM   5089 C CB  . SER E 2 90  ? -41.179 27.322  -96.747  1.00 50.84  ? 102  SER C CB  1 
ATOM   5090 O OG  . SER E 2 90  ? -40.329 26.242  -97.105  1.00 53.24  ? 102  SER C OG  1 
ATOM   5091 N N   . HIS E 2 91  ? -42.371 24.419  -95.982  1.00 53.50  ? 103  HIS C N   1 
ATOM   5092 C CA  . HIS E 2 91  ? -42.835 23.133  -96.495  1.00 46.86  ? 103  HIS C CA  1 
ATOM   5093 C C   . HIS E 2 91  ? -44.243 22.842  -95.987  1.00 49.05  ? 103  HIS C C   1 
ATOM   5094 O O   . HIS E 2 91  ? -44.514 23.020  -94.793  1.00 55.57  ? 103  HIS C O   1 
ATOM   5095 C CB  . HIS E 2 91  ? -41.880 22.021  -96.065  1.00 38.45  ? 103  HIS C CB  1 
ATOM   5096 C CG  . HIS E 2 91  ? -41.864 20.840  -96.984  1.00 30.89  ? 103  HIS C CG  1 
ATOM   5097 N ND1 . HIS E 2 91  ? -42.945 20.000  -97.137  1.00 46.24  ? 103  HIS C ND1 1 
ATOM   5098 C CD2 . HIS E 2 91  ? -40.891 20.352  -97.790  1.00 53.75  ? 103  HIS C CD2 1 
ATOM   5099 C CE1 . HIS E 2 91  ? -42.642 19.048  -98.002  1.00 64.68  ? 103  HIS C CE1 1 
ATOM   5100 N NE2 . HIS E 2 91  ? -41.402 19.239  -98.414  1.00 70.88  ? 103  HIS C NE2 1 
ATOM   5101 N N   . PRO E 2 92  ? -45.163 22.399  -96.849  1.00 48.49  ? 104  PRO C N   1 
ATOM   5102 C CA  . PRO E 2 92  ? -46.516 22.075  -96.370  1.00 47.46  ? 104  PRO C CA  1 
ATOM   5103 C C   . PRO E 2 92  ? -46.562 20.849  -95.479  1.00 51.49  ? 104  PRO C C   1 
ATOM   5104 O O   . PRO E 2 92  ? -47.511 20.707  -94.697  1.00 71.37  ? 104  PRO C O   1 
ATOM   5105 C CB  . PRO E 2 92  ? -47.304 21.849  -97.667  1.00 39.50  ? 104  PRO C CB  1 
ATOM   5106 C CG  . PRO E 2 92  ? -46.268 21.442  -98.664  1.00 35.45  ? 104  PRO C CG  1 
ATOM   5107 C CD  . PRO E 2 92  ? -45.029 22.212  -98.304  1.00 40.64  ? 104  PRO C CD  1 
ATOM   5108 N N   . GLU E 2 93  ? -45.569 19.964  -95.569  1.00 45.01  ? 105  GLU C N   1 
ATOM   5109 C CA  . GLU E 2 93  ? -45.586 18.743  -94.772  1.00 51.59  ? 105  GLU C CA  1 
ATOM   5110 C C   . GLU E 2 93  ? -45.269 19.028  -93.309  1.00 61.31  ? 105  GLU C C   1 
ATOM   5111 O O   . GLU E 2 93  ? -45.884 18.444  -92.409  1.00 71.94  ? 105  GLU C O   1 
ATOM   5112 C CB  . GLU E 2 93  ? -44.595 17.735  -95.356  1.00 56.39  ? 105  GLU C CB  1 
ATOM   5113 C CG  . GLU E 2 93  ? -44.062 16.723  -94.360  1.00 74.00  ? 105  GLU C CG  1 
ATOM   5114 C CD  . GLU E 2 93  ? -43.774 15.382  -95.001  1.00 92.36  ? 105  GLU C CD  1 
ATOM   5115 O OE1 . GLU E 2 93  ? -44.118 15.203  -96.190  1.00 101.24 ? 105  GLU C OE1 1 
ATOM   5116 O OE2 . GLU E 2 93  ? -43.200 14.509  -94.317  1.00 94.20  ? 105  GLU C OE2 1 
ATOM   5117 N N   . THR E 2 94  ? -44.325 19.931  -93.051  1.00 45.69  ? 106  THR C N   1 
ATOM   5118 C CA  . THR E 2 94  ? -43.850 20.193  -91.700  1.00 43.57  ? 106  THR C CA  1 
ATOM   5119 C C   . THR E 2 94  ? -44.369 21.501  -91.116  1.00 45.65  ? 106  THR C C   1 
ATOM   5120 O O   . THR E 2 94  ? -43.986 21.854  -89.996  1.00 47.35  ? 106  THR C O   1 
ATOM   5121 C CB  . THR E 2 94  ? -42.318 20.193  -91.679  1.00 32.89  ? 106  THR C CB  1 
ATOM   5122 O OG1 . THR E 2 94  ? -41.828 21.244  -92.521  1.00 31.78  ? 106  THR C OG1 1 
ATOM   5123 C CG2 . THR E 2 94  ? -41.785 18.863  -92.189  1.00 32.14  ? 106  THR C CG2 1 
ATOM   5124 N N   . ARG E 2 95  ? -45.240 22.221  -91.829  1.00 48.60  ? 107  ARG C N   1 
ATOM   5125 C CA  . ARG E 2 95  ? -45.672 23.534  -91.356  1.00 44.31  ? 107  ARG C CA  1 
ATOM   5126 C C   . ARG E 2 95  ? -46.565 23.424  -90.125  1.00 47.30  ? 107  ARG C C   1 
ATOM   5127 O O   . ARG E 2 95  ? -46.427 24.212  -89.180  1.00 36.74  ? 107  ARG C O   1 
ATOM   5128 C CB  . ARG E 2 95  ? -46.396 24.281  -92.473  1.00 45.94  ? 107  ARG C CB  1 
ATOM   5129 C CG  . ARG E 2 95  ? -46.533 25.773  -92.229  1.00 54.42  ? 107  ARG C CG  1 
ATOM   5130 C CD  . ARG E 2 95  ? -47.274 26.457  -93.368  1.00 68.30  ? 107  ARG C CD  1 
ATOM   5131 N NE  . ARG E 2 95  ? -48.707 26.491  -93.111  1.00 68.47  ? 107  ARG C NE  1 
ATOM   5132 C CZ  . ARG E 2 95  ? -49.549 25.520  -93.436  1.00 77.25  ? 107  ARG C CZ  1 
ATOM   5133 N NH1 . ARG E 2 95  ? -49.145 24.445  -94.095  1.00 77.25  ? 107  ARG C NH1 1 
ATOM   5134 N NH2 . ARG E 2 95  ? -50.828 25.628  -93.091  1.00 79.89  ? 107  ARG C NH2 1 
ATOM   5135 N N   . SER E 2 96  ? -47.489 22.460  -90.119  1.00 61.35  ? 108  SER C N   1 
ATOM   5136 C CA  . SER E 2 96  ? -48.408 22.317  -88.993  1.00 44.55  ? 108  SER C CA  1 
ATOM   5137 C C   . SER E 2 96  ? -47.662 21.946  -87.718  1.00 40.82  ? 108  SER C C   1 
ATOM   5138 O O   . SER E 2 96  ? -47.897 22.533  -86.655  1.00 42.74  ? 108  SER C O   1 
ATOM   5139 C CB  . SER E 2 96  ? -49.473 21.272  -89.321  1.00 41.25  ? 108  SER C CB  1 
ATOM   5140 O OG  . SER E 2 96  ? -50.247 21.673  -90.437  1.00 49.94  ? 108  SER C OG  1 
ATOM   5141 N N   . ALA E 2 97  ? -46.751 20.972  -87.806  1.00 35.79  ? 109  ALA C N   1 
ATOM   5142 C CA  . ALA E 2 97  ? -45.968 20.582  -86.639  1.00 36.49  ? 109  ALA C CA  1 
ATOM   5143 C C   . ALA E 2 97  ? -44.998 21.680  -86.220  1.00 36.52  ? 109  ALA C C   1 
ATOM   5144 O O   . ALA E 2 97  ? -44.641 21.773  -85.040  1.00 38.70  ? 109  ALA C O   1 
ATOM   5145 C CB  . ALA E 2 97  ? -45.217 19.283  -86.924  1.00 30.94  ? 109  ALA C CB  1 
ATOM   5146 N N   . PHE E 2 98  ? -44.560 22.509  -87.170  1.00 41.19  ? 110  PHE C N   1 
ATOM   5147 C CA  . PHE E 2 98  ? -43.731 23.666  -86.843  1.00 31.20  ? 110  PHE C CA  1 
ATOM   5148 C C   . PHE E 2 98  ? -44.472 24.620  -85.915  1.00 33.40  ? 110  PHE C C   1 
ATOM   5149 O O   . PHE E 2 98  ? -43.936 25.053  -84.888  1.00 39.09  ? 110  PHE C O   1 
ATOM   5150 C CB  . PHE E 2 98  ? -43.314 24.373  -88.133  1.00 39.86  ? 110  PHE C CB  1 
ATOM   5151 C CG  . PHE E 2 98  ? -42.595 25.673  -87.919  1.00 33.41  ? 110  PHE C CG  1 
ATOM   5152 C CD1 . PHE E 2 98  ? -41.236 25.694  -87.663  1.00 35.75  ? 110  PHE C CD1 1 
ATOM   5153 C CD2 . PHE E 2 98  ? -43.276 26.878  -87.996  1.00 37.12  ? 110  PHE C CD2 1 
ATOM   5154 C CE1 . PHE E 2 98  ? -40.570 26.892  -87.479  1.00 42.86  ? 110  PHE C CE1 1 
ATOM   5155 C CE2 . PHE E 2 98  ? -42.617 28.078  -87.809  1.00 35.41  ? 110  PHE C CE2 1 
ATOM   5156 C CZ  . PHE E 2 98  ? -41.263 28.086  -87.549  1.00 35.19  ? 110  PHE C CZ  1 
ATOM   5157 N N   . LEU E 2 99  ? -45.716 24.954  -86.264  1.00 33.32  ? 111  LEU C N   1 
ATOM   5158 C CA  . LEU E 2 99  ? -46.529 25.821  -85.420  1.00 34.70  ? 111  LEU C CA  1 
ATOM   5159 C C   . LEU E 2 99  ? -47.050 25.093  -84.187  1.00 37.90  ? 111  LEU C C   1 
ATOM   5160 O O   . LEU E 2 99  ? -47.218 25.715  -83.131  1.00 40.27  ? 111  LEU C O   1 
ATOM   5161 C CB  . LEU E 2 99  ? -47.696 26.389  -86.228  1.00 29.05  ? 111  LEU C CB  1 
ATOM   5162 C CG  . LEU E 2 99  ? -47.293 27.176  -87.475  1.00 21.87  ? 111  LEU C CG  1 
ATOM   5163 C CD1 . LEU E 2 99  ? -48.510 27.546  -88.310  1.00 20.72  ? 111  LEU C CD1 1 
ATOM   5164 C CD2 . LEU E 2 99  ? -46.505 28.417  -87.084  1.00 32.87  ? 111  LEU C CD2 1 
ATOM   5165 N N   . ALA E 2 100 ? -47.311 23.788  -84.299  1.00 42.41  ? 112  ALA C N   1 
ATOM   5166 C CA  . ALA E 2 100 ? -47.762 23.023  -83.141  1.00 35.11  ? 112  ALA C CA  1 
ATOM   5167 C C   . ALA E 2 100 ? -46.679 22.958  -82.075  1.00 36.53  ? 112  ALA C C   1 
ATOM   5168 O O   . ALA E 2 100 ? -46.972 23.016  -80.875  1.00 48.16  ? 112  ALA C O   1 
ATOM   5169 C CB  . ALA E 2 100 ? -48.181 21.616  -83.566  1.00 37.40  ? 112  ALA C CB  1 
ATOM   5170 N N   . ALA E 2 101 ? -45.420 22.839  -82.495  1.00 42.04  ? 113  ALA C N   1 
ATOM   5171 C CA  . ALA E 2 101 ? -44.300 22.910  -81.567  1.00 37.95  ? 113  ALA C CA  1 
ATOM   5172 C C   . ALA E 2 101 ? -44.055 24.320  -81.056  1.00 44.29  ? 113  ALA C C   1 
ATOM   5173 O O   . ALA E 2 101 ? -43.156 24.506  -80.228  1.00 43.09  ? 113  ALA C O   1 
ATOM   5174 C CB  . ALA E 2 101 ? -43.029 22.373  -82.228  1.00 30.43  ? 113  ALA C CB  1 
ATOM   5175 N N   . HIS E 2 102 ? -44.824 25.305  -81.529  1.00 46.67  ? 114  HIS C N   1 
ATOM   5176 C CA  . HIS E 2 102 ? -44.748 26.680  -81.034  1.00 39.81  ? 114  HIS C CA  1 
ATOM   5177 C C   . HIS E 2 102 ? -43.343 27.253  -81.199  1.00 38.16  ? 114  HIS C C   1 
ATOM   5178 O O   . HIS E 2 102 ? -42.802 27.889  -80.294  1.00 51.16  ? 114  HIS C O   1 
ATOM   5179 C CB  . HIS E 2 102 ? -45.200 26.767  -79.580  1.00 48.18  ? 114  HIS C CB  1 
ATOM   5180 C CG  . HIS E 2 102 ? -46.678 26.613  -79.393  1.00 42.47  ? 114  HIS C CG  1 
ATOM   5181 N ND1 . HIS E 2 102 ? -47.569 26.661  -80.443  1.00 46.75  ? 114  HIS C ND1 1 
ATOM   5182 C CD2 . HIS E 2 102 ? -47.422 26.425  -78.276  1.00 38.35  ? 114  HIS C CD2 1 
ATOM   5183 C CE1 . HIS E 2 102 ? -48.797 26.501  -79.982  1.00 50.58  ? 114  HIS C CE1 1 
ATOM   5184 N NE2 . HIS E 2 102 ? -48.736 26.353  -78.671  1.00 57.58  ? 114  HIS C NE2 1 
ATOM   5185 N N   . ILE E 2 103 ? -42.745 27.024  -82.364  1.00 29.33  ? 115  ILE C N   1 
ATOM   5186 C CA  . ILE E 2 103 ? -41.380 27.471  -82.641  1.00 32.00  ? 115  ILE C CA  1 
ATOM   5187 C C   . ILE E 2 103 ? -41.302 28.984  -82.831  1.00 41.94  ? 115  ILE C C   1 
ATOM   5188 O O   . ILE E 2 103 ? -40.367 29.606  -82.301  1.00 45.38  ? 115  ILE C O   1 
ATOM   5189 C CB  . ILE E 2 103 ? -40.795 26.758  -83.864  1.00 31.78  ? 115  ILE C CB  1 
ATOM   5190 C CG1 . ILE E 2 103 ? -40.607 25.270  -83.566  1.00 37.19  ? 115  ILE C CG1 1 
ATOM   5191 C CG2 . ILE E 2 103 ? -39.473 27.402  -84.270  1.00 27.86  ? 115  ILE C CG2 1 
ATOM   5192 C CD1 . ILE E 2 103 ? -39.208 24.904  -83.130  1.00 45.58  ? 115  ILE C CD1 1 
ATOM   5193 N N   . PRO E 2 104 ? -42.220 29.629  -83.573  1.00 39.81  ? 116  PRO C N   1 
ATOM   5194 C CA  . PRO E 2 104 ? -42.066 31.080  -83.805  1.00 28.03  ? 116  PRO C CA  1 
ATOM   5195 C C   . PRO E 2 104 ? -41.930 31.918  -82.543  1.00 39.09  ? 116  PRO C C   1 
ATOM   5196 O O   . PRO E 2 104 ? -41.232 32.936  -82.579  1.00 41.85  ? 116  PRO C O   1 
ATOM   5197 C CB  . PRO E 2 104 ? -43.340 31.440  -84.580  1.00 29.09  ? 116  PRO C CB  1 
ATOM   5198 C CG  . PRO E 2 104 ? -43.685 30.199  -85.297  1.00 24.68  ? 116  PRO C CG  1 
ATOM   5199 C CD  . PRO E 2 104 ? -43.369 29.097  -84.335  1.00 40.47  ? 116  PRO C CD  1 
ATOM   5200 N N   . LEU E 2 105 ? -42.554 31.524  -81.427  1.00 48.83  ? 117  LEU C N   1 
ATOM   5201 C CA  . LEU E 2 105 ? -42.473 32.299  -80.188  1.00 44.95  ? 117  LEU C CA  1 
ATOM   5202 C C   . LEU E 2 105 ? -41.052 32.477  -79.672  1.00 45.51  ? 117  LEU C C   1 
ATOM   5203 O O   . LEU E 2 105 ? -40.838 33.316  -78.788  1.00 47.19  ? 117  LEU C O   1 
ATOM   5204 C CB  . LEU E 2 105 ? -43.348 31.665  -79.101  1.00 35.09  ? 117  LEU C CB  1 
ATOM   5205 C CG  . LEU E 2 105 ? -44.829 31.496  -79.447  1.00 43.45  ? 117  LEU C CG  1 
ATOM   5206 C CD1 . LEU E 2 105 ? -45.094 30.186  -80.132  1.00 53.55  ? 117  LEU C CD1 1 
ATOM   5207 C CD2 . LEU E 2 105 ? -45.654 31.586  -78.168  1.00 58.49  ? 117  LEU C CD2 1 
ATOM   5208 N N   . PHE E 2 106 ? -40.082 31.726  -80.190  1.00 37.19  ? 118  PHE C N   1 
ATOM   5209 C CA  . PHE E 2 106 ? -38.685 31.979  -79.866  1.00 42.69  ? 118  PHE C CA  1 
ATOM   5210 C C   . PHE E 2 106 ? -38.026 32.956  -80.831  1.00 44.75  ? 118  PHE C C   1 
ATOM   5211 O O   . PHE E 2 106 ? -36.957 33.490  -80.518  1.00 42.41  ? 118  PHE C O   1 
ATOM   5212 C CB  . PHE E 2 106 ? -37.910 30.660  -79.825  1.00 39.59  ? 118  PHE C CB  1 
ATOM   5213 C CG  . PHE E 2 106 ? -38.344 29.749  -78.711  1.00 51.60  ? 118  PHE C CG  1 
ATOM   5214 C CD1 . PHE E 2 106 ? -39.369 28.837  -78.901  1.00 53.87  ? 118  PHE C CD1 1 
ATOM   5215 C CD2 . PHE E 2 106 ? -37.741 29.822  -77.466  1.00 54.41  ? 118  PHE C CD2 1 
ATOM   5216 C CE1 . PHE E 2 106 ? -39.775 28.004  -77.874  1.00 43.92  ? 118  PHE C CE1 1 
ATOM   5217 C CE2 . PHE E 2 106 ? -38.141 28.992  -76.438  1.00 55.79  ? 118  PHE C CE2 1 
ATOM   5218 C CZ  . PHE E 2 106 ? -39.161 28.084  -76.641  1.00 43.91  ? 118  PHE C CZ  1 
ATOM   5219 N N   . LEU E 2 107 ? -38.640 33.196  -81.992  1.00 50.87  ? 119  LEU C N   1 
ATOM   5220 C CA  . LEU E 2 107 ? -38.270 34.323  -82.838  1.00 34.91  ? 119  LEU C CA  1 
ATOM   5221 C C   . LEU E 2 107 ? -38.864 35.628  -82.338  1.00 35.36  ? 119  LEU C C   1 
ATOM   5222 O O   . LEU E 2 107 ? -38.315 36.695  -82.630  1.00 49.24  ? 119  LEU C O   1 
ATOM   5223 C CB  . LEU E 2 107 ? -38.729 34.085  -84.277  1.00 26.02  ? 119  LEU C CB  1 
ATOM   5224 C CG  . LEU E 2 107 ? -37.855 33.192  -85.154  1.00 31.86  ? 119  LEU C CG  1 
ATOM   5225 C CD1 . LEU E 2 107 ? -38.091 31.719  -84.849  1.00 32.28  ? 119  LEU C CD1 1 
ATOM   5226 C CD2 . LEU E 2 107 ? -38.110 33.490  -86.619  1.00 25.41  ? 119  LEU C CD2 1 
ATOM   5227 N N   . TYR E 2 108 ? -39.969 35.558  -81.599  1.00 44.81  ? 120  TYR C N   1 
ATOM   5228 C CA  . TYR E 2 108 ? -40.625 36.757  -81.084  1.00 39.70  ? 120  TYR C CA  1 
ATOM   5229 C C   . TYR E 2 108 ? -39.701 37.659  -80.272  1.00 43.23  ? 120  TYR C C   1 
ATOM   5230 O O   . TYR E 2 108 ? -39.803 38.888  -80.425  1.00 50.52  ? 120  TYR C O   1 
ATOM   5231 C CB  . TYR E 2 108 ? -41.850 36.349  -80.249  1.00 43.57  ? 120  TYR C CB  1 
ATOM   5232 C CG  . TYR E 2 108 ? -43.067 35.935  -81.056  1.00 43.24  ? 120  TYR C CG  1 
ATOM   5233 C CD1 . TYR E 2 108 ? -42.934 35.373  -82.320  1.00 41.70  ? 120  TYR C CD1 1 
ATOM   5234 C CD2 . TYR E 2 108 ? -44.348 36.077  -80.540  1.00 51.34  ? 120  TYR C CD2 1 
ATOM   5235 C CE1 . TYR E 2 108 ? -44.038 34.983  -83.051  1.00 39.81  ? 120  TYR C CE1 1 
ATOM   5236 C CE2 . TYR E 2 108 ? -45.460 35.689  -81.266  1.00 39.00  ? 120  TYR C CE2 1 
ATOM   5237 C CZ  . TYR E 2 108 ? -45.299 35.143  -82.520  1.00 37.55  ? 120  TYR C CZ  1 
ATOM   5238 O OH  . TYR E 2 108 ? -46.401 34.756  -83.247  1.00 52.96  ? 120  TYR C OH  1 
ATOM   5239 N N   . PRO E 2 109 ? -38.813 37.152  -79.405  1.00 46.98  ? 121  PRO C N   1 
ATOM   5240 C CA  . PRO E 2 109 ? -37.865 38.062  -78.740  1.00 46.28  ? 121  PRO C CA  1 
ATOM   5241 C C   . PRO E 2 109 ? -36.974 38.822  -79.709  1.00 54.28  ? 121  PRO C C   1 
ATOM   5242 O O   . PRO E 2 109 ? -36.569 39.951  -79.405  1.00 72.29  ? 121  PRO C O   1 
ATOM   5243 C CB  . PRO E 2 109 ? -37.052 37.123  -77.840  1.00 39.17  ? 121  PRO C CB  1 
ATOM   5244 C CG  . PRO E 2 109 ? -37.970 35.994  -77.562  1.00 43.99  ? 121  PRO C CG  1 
ATOM   5245 C CD  . PRO E 2 109 ? -38.741 35.792  -78.833  1.00 49.15  ? 121  PRO C CD  1 
ATOM   5246 N N   . PHE E 2 110 ? -36.657 38.241  -80.870  1.00 52.11  ? 122  PHE C N   1 
ATOM   5247 C CA  . PHE E 2 110 ? -35.829 38.949  -81.841  1.00 42.08  ? 122  PHE C CA  1 
ATOM   5248 C C   . PHE E 2 110 ? -36.551 40.157  -82.424  1.00 52.04  ? 122  PHE C C   1 
ATOM   5249 O O   . PHE E 2 110 ? -35.903 41.140  -82.800  1.00 57.16  ? 122  PHE C O   1 
ATOM   5250 C CB  . PHE E 2 110 ? -35.395 38.000  -82.958  1.00 32.99  ? 122  PHE C CB  1 
ATOM   5251 C CG  . PHE E 2 110 ? -34.440 36.929  -82.510  1.00 42.42  ? 122  PHE C CG  1 
ATOM   5252 C CD1 . PHE E 2 110 ? -33.568 37.154  -81.457  1.00 36.52  ? 122  PHE C CD1 1 
ATOM   5253 C CD2 . PHE E 2 110 ? -34.411 35.698  -83.144  1.00 48.02  ? 122  PHE C CD2 1 
ATOM   5254 C CE1 . PHE E 2 110 ? -32.686 36.169  -81.044  1.00 27.50  ? 122  PHE C CE1 1 
ATOM   5255 C CE2 . PHE E 2 110 ? -33.530 34.710  -82.735  1.00 41.55  ? 122  PHE C CE2 1 
ATOM   5256 C CZ  . PHE E 2 110 ? -32.668 34.947  -81.684  1.00 30.37  ? 122  PHE C CZ  1 
ATOM   5257 N N   . LEU E 2 111 ? -37.883 40.109  -82.502  1.00 61.40  ? 123  LEU C N   1 
ATOM   5258 C CA  . LEU E 2 111 ? -38.661 41.231  -83.011  1.00 53.63  ? 123  LEU C CA  1 
ATOM   5259 C C   . LEU E 2 111 ? -38.879 42.328  -81.975  1.00 65.41  ? 123  LEU C C   1 
ATOM   5260 O O   . LEU E 2 111 ? -39.369 43.402  -82.331  1.00 54.72  ? 123  LEU C O   1 
ATOM   5261 C CB  . LEU E 2 111 ? -40.018 40.745  -83.531  1.00 34.51  ? 123  LEU C CB  1 
ATOM   5262 C CG  . LEU E 2 111 ? -39.995 39.581  -84.523  1.00 28.36  ? 123  LEU C CG  1 
ATOM   5263 C CD1 . LEU E 2 111 ? -41.397 39.018  -84.735  1.00 26.67  ? 123  LEU C CD1 1 
ATOM   5264 C CD2 . LEU E 2 111 ? -39.378 40.011  -85.844  1.00 39.16  ? 123  LEU C CD2 1 
ATOM   5265 N N   . HIS E 2 112 ? -38.536 42.098  -80.712  1.00 66.53  ? 124  HIS C N   1 
ATOM   5266 C CA  . HIS E 2 112 ? -38.680 43.137  -79.702  1.00 67.58  ? 124  HIS C CA  1 
ATOM   5267 C C   . HIS E 2 112 ? -37.452 44.032  -79.593  1.00 74.88  ? 124  HIS C C   1 
ATOM   5268 O O   . HIS E 2 112 ? -37.524 45.079  -78.939  1.00 83.70  ? 124  HIS C O   1 
ATOM   5269 C CB  . HIS E 2 112 ? -38.981 42.512  -78.334  1.00 64.00  ? 124  HIS C CB  1 
ATOM   5270 C CG  . HIS E 2 112 ? -39.510 43.487  -77.329  1.00 72.14  ? 124  HIS C CG  1 
ATOM   5271 N ND1 . HIS E 2 112 ? -38.858 43.770  -76.149  1.00 78.17  ? 124  HIS C ND1 1 
ATOM   5272 C CD2 . HIS E 2 112 ? -40.629 44.250  -77.333  1.00 78.31  ? 124  HIS C CD2 1 
ATOM   5273 C CE1 . HIS E 2 112 ? -39.553 44.663  -75.467  1.00 84.61  ? 124  HIS C CE1 1 
ATOM   5274 N NE2 . HIS E 2 112 ? -40.632 44.971  -76.163  1.00 78.17  ? 124  HIS C NE2 1 
ATOM   5275 N N   . THR E 2 113 ? -36.341 43.657  -80.222  1.00 72.25  ? 125  THR C N   1 
ATOM   5276 C CA  . THR E 2 113 ? -35.115 44.432  -80.106  1.00 64.85  ? 125  THR C CA  1 
ATOM   5277 C C   . THR E 2 113 ? -35.235 45.758  -80.848  1.00 78.29  ? 125  THR C C   1 
ATOM   5278 O O   . THR E 2 113 ? -35.915 45.870  -81.872  1.00 82.96  ? 125  THR C O   1 
ATOM   5279 C CB  . THR E 2 113 ? -33.922 43.642  -80.648  1.00 63.70  ? 125  THR C CB  1 
ATOM   5280 O OG1 . THR E 2 113 ? -33.977 43.607  -82.080  1.00 61.76  ? 125  THR C OG1 1 
ATOM   5281 C CG2 . THR E 2 113 ? -33.936 42.221  -80.108  1.00 55.79  ? 125  THR C CG2 1 
ATOM   5282 N N   . VAL E 2 114 ? -34.551 46.767  -80.315  1.00 66.66  ? 126  VAL C N   1 
ATOM   5283 C CA  . VAL E 2 114 ? -34.582 48.126  -80.837  1.00 71.33  ? 126  VAL C CA  1 
ATOM   5284 C C   . VAL E 2 114 ? -33.192 48.613  -81.237  1.00 72.10  ? 126  VAL C C   1 
ATOM   5285 O O   . VAL E 2 114 ? -33.075 49.635  -81.924  1.00 86.92  ? 126  VAL C O   1 
ATOM   5286 C CB  . VAL E 2 114 ? -35.255 49.068  -79.808  1.00 74.05  ? 126  VAL C CB  1 
ATOM   5287 C CG1 . VAL E 2 114 ? -34.791 50.523  -79.880  1.00 84.99  ? 126  VAL C CG1 1 
ATOM   5288 C CG2 . VAL E 2 114 ? -36.776 48.984  -79.942  1.00 80.60  ? 126  VAL C CG2 1 
ATOM   5289 N N   . SER E 2 115 ? -32.154 47.816  -80.952  1.00 64.93  ? 127  SER C N   1 
ATOM   5290 C CA  . SER E 2 115 ? -30.757 48.256  -80.993  1.00 74.70  ? 127  SER C CA  1 
ATOM   5291 C C   . SER E 2 115 ? -30.411 49.079  -82.232  1.00 80.55  ? 127  SER C C   1 
ATOM   5292 O O   . SER E 2 115 ? -29.698 50.085  -82.131  1.00 97.26  ? 127  SER C O   1 
ATOM   5293 C CB  . SER E 2 115 ? -29.840 47.034  -80.901  1.00 73.25  ? 127  SER C CB  1 
ATOM   5294 O OG  . SER E 2 115 ? -28.547 47.315  -81.405  1.00 76.52  ? 127  SER C OG  1 
ATOM   5295 N N   . LYS E 2 116 ? -30.882 48.659  -83.406  1.00 70.45  ? 128  LYS C N   1 
ATOM   5296 C CA  . LYS E 2 116 ? -30.661 49.285  -84.717  1.00 81.74  ? 128  LYS C CA  1 
ATOM   5297 C C   . LYS E 2 116 ? -29.255 49.040  -85.269  1.00 67.82  ? 128  LYS C C   1 
ATOM   5298 O O   . LYS E 2 116 ? -28.932 49.588  -86.332  1.00 56.58  ? 128  LYS C O   1 
ATOM   5299 C CB  . LYS E 2 116 ? -30.926 50.802  -84.718  1.00 67.31  ? 128  LYS C CB  1 
ATOM   5300 C CG  . LYS E 2 116 ? -32.314 51.206  -85.192  1.00 67.53  ? 128  LYS C CG  1 
ATOM   5301 C CD  . LYS E 2 116 ? -32.669 52.610  -84.719  1.00 85.70  ? 128  LYS C CD  1 
ATOM   5302 C CE  . LYS E 2 116 ? -32.702 53.603  -85.875  1.00 80.89  ? 128  LYS C CE  1 
ATOM   5303 N NZ  . LYS E 2 116 ? -33.211 54.942  -85.455  1.00 46.27  ? 128  LYS C NZ  1 
ATOM   5304 N N   . THR E 2 117 ? -28.413 48.254  -84.601  1.00 63.13  ? 129  THR C N   1 
ATOM   5305 C CA  . THR E 2 117 ? -27.135 47.869  -85.185  1.00 58.90  ? 129  THR C CA  1 
ATOM   5306 C C   . THR E 2 117 ? -27.364 46.881  -86.327  1.00 60.39  ? 129  THR C C   1 
ATOM   5307 O O   . THR E 2 117 ? -28.424 46.260  -86.438  1.00 81.15  ? 129  THR C O   1 
ATOM   5308 C CB  . THR E 2 117 ? -26.223 47.242  -84.127  1.00 50.82  ? 129  THR C CB  1 
ATOM   5309 O OG1 . THR E 2 117 ? -26.471 47.853  -82.856  1.00 72.94  ? 129  THR C OG1 1 
ATOM   5310 C CG2 . THR E 2 117 ? -24.759 47.450  -84.490  1.00 55.09  ? 129  THR C CG2 1 
ATOM   5311 N N   . ARG E 2 118 ? -26.356 46.740  -87.188  1.00 51.61  ? 130  ARG C N   1 
ATOM   5312 C CA  . ARG E 2 118 ? -26.490 45.816  -88.312  1.00 69.89  ? 130  ARG C CA  1 
ATOM   5313 C C   . ARG E 2 118 ? -26.679 44.362  -87.882  1.00 69.24  ? 130  ARG C C   1 
ATOM   5314 O O   . ARG E 2 118 ? -27.508 43.674  -88.503  1.00 77.97  ? 130  ARG C O   1 
ATOM   5315 C CB  . ARG E 2 118 ? -25.291 45.953  -89.260  1.00 68.31  ? 130  ARG C CB  1 
ATOM   5316 C CG  . ARG E 2 118 ? -25.491 45.222  -90.582  1.00 66.19  ? 130  ARG C CG  1 
ATOM   5317 C CD  . ARG E 2 118 ? -24.539 45.698  -91.666  1.00 78.28  ? 130  ARG C CD  1 
ATOM   5318 N NE  . ARG E 2 118 ? -25.199 46.561  -92.637  1.00 77.14  ? 130  ARG C NE  1 
ATOM   5319 C CZ  . ARG E 2 118 ? -24.800 46.714  -93.892  1.00 72.37  ? 130  ARG C CZ  1 
ATOM   5320 N NH1 . ARG E 2 118 ? -23.757 46.054  -94.369  1.00 69.33  ? 130  ARG C NH1 1 
ATOM   5321 N NH2 . ARG E 2 118 ? -25.469 47.541  -94.691  1.00 71.63  ? 130  ARG C NH2 1 
ATOM   5322 N N   . PRO E 2 119 ? -25.969 43.828  -86.877  1.00 55.13  ? 131  PRO C N   1 
ATOM   5323 C CA  . PRO E 2 119 ? -26.312 42.473  -86.411  1.00 60.99  ? 131  PRO C CA  1 
ATOM   5324 C C   . PRO E 2 119 ? -27.743 42.352  -85.910  1.00 55.91  ? 131  PRO C C   1 
ATOM   5325 O O   . PRO E 2 119 ? -28.387 41.320  -86.134  1.00 50.16  ? 131  PRO C O   1 
ATOM   5326 C CB  . PRO E 2 119 ? -25.289 42.225  -85.293  1.00 65.09  ? 131  PRO C CB  1 
ATOM   5327 C CG  . PRO E 2 119 ? -24.119 43.039  -85.691  1.00 60.72  ? 131  PRO C CG  1 
ATOM   5328 C CD  . PRO E 2 119 ? -24.708 44.297  -86.274  1.00 67.99  ? 131  PRO C CD  1 
ATOM   5329 N N   . PHE E 2 120 ? -28.263 43.385  -85.242  1.00 61.30  ? 132  PHE C N   1 
ATOM   5330 C CA  . PHE E 2 120 ? -29.642 43.348  -84.768  1.00 60.31  ? 132  PHE C CA  1 
ATOM   5331 C C   . PHE E 2 120 ? -30.638 43.710  -85.865  1.00 61.87  ? 132  PHE C C   1 
ATOM   5332 O O   . PHE E 2 120 ? -31.760 43.191  -85.872  1.00 67.19  ? 132  PHE C O   1 
ATOM   5333 C CB  . PHE E 2 120 ? -29.816 44.285  -83.572  1.00 53.94  ? 132  PHE C CB  1 
ATOM   5334 C CG  . PHE E 2 120 ? -29.286 43.725  -82.284  1.00 61.84  ? 132  PHE C CG  1 
ATOM   5335 C CD1 . PHE E 2 120 ? -30.037 42.828  -81.543  1.00 66.11  ? 132  PHE C CD1 1 
ATOM   5336 C CD2 . PHE E 2 120 ? -28.037 44.097  -81.813  1.00 73.36  ? 132  PHE C CD2 1 
ATOM   5337 C CE1 . PHE E 2 120 ? -29.552 42.311  -80.356  1.00 77.83  ? 132  PHE C CE1 1 
ATOM   5338 C CE2 . PHE E 2 120 ? -27.546 43.586  -80.626  1.00 76.06  ? 132  PHE C CE2 1 
ATOM   5339 C CZ  . PHE E 2 120 ? -28.305 42.690  -79.897  1.00 84.42  ? 132  PHE C CZ  1 
ATOM   5340 N N   . GLU E 2 121 ? -30.258 44.596  -86.790  1.00 55.42  ? 133  GLU C N   1 
ATOM   5341 C CA  . GLU E 2 121 ? -31.133 44.896  -87.918  1.00 49.27  ? 133  GLU C CA  1 
ATOM   5342 C C   . GLU E 2 121 ? -31.260 43.702  -88.855  1.00 58.58  ? 133  GLU C C   1 
ATOM   5343 O O   . GLU E 2 121 ? -32.326 43.488  -89.443  1.00 61.08  ? 133  GLU C O   1 
ATOM   5344 C CB  . GLU E 2 121 ? -30.617 46.116  -88.680  1.00 54.85  ? 133  GLU C CB  1 
ATOM   5345 C CG  . GLU E 2 121 ? -31.604 46.670  -89.692  1.00 68.45  ? 133  GLU C CG  1 
ATOM   5346 C CD  . GLU E 2 121 ? -32.950 46.992  -89.073  1.00 78.02  ? 133  GLU C CD  1 
ATOM   5347 O OE1 . GLU E 2 121 ? -33.017 47.916  -88.234  1.00 69.54  ? 133  GLU C OE1 1 
ATOM   5348 O OE2 . GLU E 2 121 ? -33.943 46.320  -89.425  1.00 69.69  ? 133  GLU C OE2 1 
ATOM   5349 N N   . TYR E 2 122 ? -30.188 42.920  -89.009  1.00 58.28  ? 134  TYR C N   1 
ATOM   5350 C CA  . TYR E 2 122 ? -30.270 41.696  -89.801  1.00 50.04  ? 134  TYR C CA  1 
ATOM   5351 C C   . TYR E 2 122 ? -31.062 40.623  -89.066  1.00 51.78  ? 134  TYR C C   1 
ATOM   5352 O O   . TYR E 2 122 ? -31.858 39.902  -89.679  1.00 56.94  ? 134  TYR C O   1 
ATOM   5353 C CB  . TYR E 2 122 ? -28.863 41.194  -90.138  1.00 50.39  ? 134  TYR C CB  1 
ATOM   5354 C CG  . TYR E 2 122 ? -28.824 39.937  -90.988  1.00 47.69  ? 134  TYR C CG  1 
ATOM   5355 C CD1 . TYR E 2 122 ? -29.754 39.724  -92.000  1.00 58.56  ? 134  TYR C CD1 1 
ATOM   5356 C CD2 . TYR E 2 122 ? -27.849 38.967  -90.781  1.00 45.32  ? 134  TYR C CD2 1 
ATOM   5357 C CE1 . TYR E 2 122 ? -29.717 38.577  -92.777  1.00 55.50  ? 134  TYR C CE1 1 
ATOM   5358 C CE2 . TYR E 2 122 ? -27.804 37.818  -91.554  1.00 39.51  ? 134  TYR C CE2 1 
ATOM   5359 C CZ  . TYR E 2 122 ? -28.740 37.627  -92.549  1.00 45.91  ? 134  TYR C CZ  1 
ATOM   5360 O OH  . TYR E 2 122 ? -28.701 36.485  -93.318  1.00 50.20  ? 134  TYR C OH  1 
ATOM   5361 N N   . LEU E 2 123 ? -30.859 40.507  -87.750  1.00 54.50  ? 135  LEU C N   1 
ATOM   5362 C CA  . LEU E 2 123 ? -31.600 39.521  -86.970  1.00 50.57  ? 135  LEU C CA  1 
ATOM   5363 C C   . LEU E 2 123 ? -33.099 39.788  -87.030  1.00 46.57  ? 135  LEU C C   1 
ATOM   5364 O O   . LEU E 2 123 ? -33.899 38.855  -87.172  1.00 53.89  ? 135  LEU C O   1 
ATOM   5365 C CB  . LEU E 2 123 ? -31.109 39.524  -85.521  1.00 50.21  ? 135  LEU C CB  1 
ATOM   5366 C CG  . LEU E 2 123 ? -31.540 38.355  -84.631  1.00 38.35  ? 135  LEU C CG  1 
ATOM   5367 C CD1 . LEU E 2 123 ? -31.473 37.041  -85.397  1.00 34.71  ? 135  LEU C CD1 1 
ATOM   5368 C CD2 . LEU E 2 123 ? -30.694 38.291  -83.364  1.00 33.11  ? 135  LEU C CD2 1 
ATOM   5369 N N   . ARG E 2 124 ? -33.500 41.058  -86.933  1.00 41.19  ? 136  ARG C N   1 
ATOM   5370 C CA  . ARG E 2 124 ? -34.916 41.391  -87.039  1.00 41.15  ? 136  ARG C CA  1 
ATOM   5371 C C   . ARG E 2 124 ? -35.449 41.094  -88.435  1.00 49.10  ? 136  ARG C C   1 
ATOM   5372 O O   . ARG E 2 124 ? -36.569 40.592  -88.584  1.00 51.95  ? 136  ARG C O   1 
ATOM   5373 C CB  . ARG E 2 124 ? -35.139 42.860  -86.680  1.00 39.11  ? 136  ARG C CB  1 
ATOM   5374 C CG  . ARG E 2 124 ? -36.000 43.073  -85.446  1.00 48.73  ? 136  ARG C CG  1 
ATOM   5375 C CD  . ARG E 2 124 ? -36.153 44.551  -85.123  1.00 61.12  ? 136  ARG C CD  1 
ATOM   5376 N NE  . ARG E 2 124 ? -34.923 45.121  -84.588  1.00 66.28  ? 136  ARG C NE  1 
ATOM   5377 C CZ  . ARG E 2 124 ? -34.237 46.098  -85.164  1.00 63.21  ? 136  ARG C CZ  1 
ATOM   5378 N NH1 . ARG E 2 124 ? -34.641 46.652  -86.296  1.00 56.16  ? 136  ARG C NH1 1 
ATOM   5379 N NH2 . ARG E 2 124 ? -33.117 46.531  -84.590  1.00 55.37  ? 136  ARG C NH2 1 
ATOM   5380 N N   . LEU E 2 125 ? -34.653 41.381  -89.470  1.00 55.04  ? 137  LEU C N   1 
ATOM   5381 C CA  . LEU E 2 125 ? -35.122 41.207  -90.841  1.00 51.04  ? 137  LEU C CA  1 
ATOM   5382 C C   . LEU E 2 125 ? -35.281 39.735  -91.209  1.00 42.05  ? 137  LEU C C   1 
ATOM   5383 O O   . LEU E 2 125 ? -36.171 39.388  -91.993  1.00 50.03  ? 137  LEU C O   1 
ATOM   5384 C CB  . LEU E 2 125 ? -34.166 41.899  -91.815  1.00 53.82  ? 137  LEU C CB  1 
ATOM   5385 C CG  . LEU E 2 125 ? -34.328 43.414  -91.970  1.00 46.94  ? 137  LEU C CG  1 
ATOM   5386 C CD1 . LEU E 2 125 ? -33.432 43.944  -93.082  1.00 52.83  ? 137  LEU C CD1 1 
ATOM   5387 C CD2 . LEU E 2 125 ? -35.785 43.786  -92.220  1.00 43.02  ? 137  LEU C CD2 1 
ATOM   5388 N N   . THR E 2 126 ? -34.431 38.860  -90.668  1.00 31.93  ? 138  THR C N   1 
ATOM   5389 C CA  . THR E 2 126 ? -34.588 37.432  -90.927  1.00 38.09  ? 138  THR C CA  1 
ATOM   5390 C C   . THR E 2 126 ? -35.767 36.857  -90.149  1.00 54.12  ? 138  THR C C   1 
ATOM   5391 O O   . THR E 2 126 ? -36.501 36.007  -90.668  1.00 54.60  ? 138  THR C O   1 
ATOM   5392 C CB  . THR E 2 126 ? -33.296 36.686  -90.583  1.00 36.33  ? 138  THR C CB  1 
ATOM   5393 O OG1 . THR E 2 126 ? -32.185 37.347  -91.200  1.00 47.56  ? 138  THR C OG1 1 
ATOM   5394 C CG2 . THR E 2 126 ? -33.352 35.247  -91.080  1.00 42.98  ? 138  THR C CG2 1 
ATOM   5395 N N   . SER E 2 127 ? -35.967 37.315  -88.909  1.00 49.56  ? 139  SER C N   1 
ATOM   5396 C CA  . SER E 2 127 ? -37.130 36.885  -88.137  1.00 31.11  ? 139  SER C CA  1 
ATOM   5397 C C   . SER E 2 127 ? -38.426 37.369  -88.776  1.00 39.03  ? 139  SER C C   1 
ATOM   5398 O O   . SER E 2 127 ? -39.427 36.641  -88.795  1.00 41.33  ? 139  SER C O   1 
ATOM   5399 C CB  . SER E 2 127 ? -37.020 37.387  -86.697  1.00 32.67  ? 139  SER C CB  1 
ATOM   5400 O OG  . SER E 2 127 ? -35.868 36.865  -86.056  1.00 35.34  ? 139  SER C OG  1 
ATOM   5401 N N   . LEU E 2 128 ? -38.427 38.595  -89.306  1.00 45.84  ? 140  LEU C N   1 
ATOM   5402 C CA  . LEU E 2 128 ? -39.593 39.090  -90.029  1.00 36.98  ? 140  LEU C CA  1 
ATOM   5403 C C   . LEU E 2 128 ? -39.851 38.287  -91.300  1.00 37.69  ? 140  LEU C C   1 
ATOM   5404 O O   . LEU E 2 128 ? -41.004 38.160  -91.727  1.00 33.95  ? 140  LEU C O   1 
ATOM   5405 C CB  . LEU E 2 128 ? -39.415 40.571  -90.368  1.00 35.84  ? 140  LEU C CB  1 
ATOM   5406 C CG  . LEU E 2 128 ? -39.604 41.582  -89.233  1.00 32.73  ? 140  LEU C CG  1 
ATOM   5407 C CD1 . LEU E 2 128 ? -38.687 42.782  -89.430  1.00 38.42  ? 140  LEU C CD1 1 
ATOM   5408 C CD2 . LEU E 2 128 ? -41.058 42.023  -89.124  1.00 35.79  ? 140  LEU C CD2 1 
ATOM   5409 N N   . GLY E 2 129 ? -38.798 37.745  -91.917  1.00 46.87  ? 141  GLY C N   1 
ATOM   5410 C CA  . GLY E 2 129 ? -38.986 36.942  -93.113  1.00 36.02  ? 141  GLY C CA  1 
ATOM   5411 C C   . GLY E 2 129 ? -39.617 35.594  -92.831  1.00 39.59  ? 141  GLY C C   1 
ATOM   5412 O O   . GLY E 2 129 ? -40.280 35.022  -93.701  1.00 43.04  ? 141  GLY C O   1 
ATOM   5413 N N   . VAL E 2 130 ? -39.420 35.066  -91.622  1.00 43.33  ? 142  VAL C N   1 
ATOM   5414 C CA  . VAL E 2 130 ? -40.044 33.800  -91.253  1.00 38.56  ? 142  VAL C CA  1 
ATOM   5415 C C   . VAL E 2 130 ? -41.552 33.970  -91.125  1.00 35.99  ? 142  VAL C C   1 
ATOM   5416 O O   . VAL E 2 130 ? -42.331 33.256  -91.767  1.00 33.06  ? 142  VAL C O   1 
ATOM   5417 C CB  . VAL E 2 130 ? -39.424 33.257  -89.954  1.00 24.67  ? 142  VAL C CB  1 
ATOM   5418 C CG1 . VAL E 2 130 ? -40.339 32.218  -89.321  1.00 19.74  ? 142  VAL C CG1 1 
ATOM   5419 C CG2 . VAL E 2 130 ? -38.052 32.671  -90.234  1.00 27.10  ? 142  VAL C CG2 1 
ATOM   5420 N N   . ILE E 2 131 ? -41.985 34.920  -90.291  1.00 37.24  ? 143  ILE C N   1 
ATOM   5421 C CA  . ILE E 2 131 ? -43.411 35.191  -90.156  1.00 33.68  ? 143  ILE C CA  1 
ATOM   5422 C C   . ILE E 2 131 ? -43.978 35.739  -91.460  1.00 41.55  ? 143  ILE C C   1 
ATOM   5423 O O   . ILE E 2 131 ? -45.130 35.455  -91.813  1.00 45.39  ? 143  ILE C O   1 
ATOM   5424 C CB  . ILE E 2 131 ? -43.657 36.148  -88.974  1.00 29.65  ? 143  ILE C CB  1 
ATOM   5425 C CG1 . ILE E 2 131 ? -43.308 35.455  -87.656  1.00 23.53  ? 143  ILE C CG1 1 
ATOM   5426 C CG2 . ILE E 2 131 ? -45.105 36.610  -88.940  1.00 40.52  ? 143  ILE C CG2 1 
ATOM   5427 C CD1 . ILE E 2 131 ? -42.047 35.975  -87.008  1.00 26.70  ? 143  ILE C CD1 1 
ATOM   5428 N N   . GLY E 2 132 ? -43.184 36.512  -92.205  1.00 46.03  ? 144  GLY C N   1 
ATOM   5429 C CA  . GLY E 2 132 ? -43.638 36.992  -93.499  1.00 38.16  ? 144  GLY C CA  1 
ATOM   5430 C C   . GLY E 2 132 ? -43.818 35.880  -94.510  1.00 46.34  ? 144  GLY C C   1 
ATOM   5431 O O   . GLY E 2 132 ? -44.687 35.962  -95.383  1.00 45.79  ? 144  GLY C O   1 
ATOM   5432 N N   . ALA E 2 133 ? -42.999 34.831  -94.415  1.00 42.33  ? 145  ALA C N   1 
ATOM   5433 C CA  . ALA E 2 133 ? -43.211 33.660  -95.255  1.00 32.11  ? 145  ALA C CA  1 
ATOM   5434 C C   . ALA E 2 133 ? -44.442 32.881  -94.813  1.00 38.37  ? 145  ALA C C   1 
ATOM   5435 O O   . ALA E 2 133 ? -45.114 32.266  -95.646  1.00 46.49  ? 145  ALA C O   1 
ATOM   5436 C CB  . ALA E 2 133 ? -41.974 32.764  -95.232  1.00 45.15  ? 145  ALA C CB  1 
ATOM   5437 N N   . LEU E 2 134 ? -44.755 32.909  -93.515  1.00 39.66  ? 146  LEU C N   1 
ATOM   5438 C CA  . LEU E 2 134 ? -45.919 32.189  -93.008  1.00 30.98  ? 146  LEU C CA  1 
ATOM   5439 C C   . LEU E 2 134 ? -47.221 32.864  -93.428  1.00 43.35  ? 146  LEU C C   1 
ATOM   5440 O O   . LEU E 2 134 ? -48.189 32.184  -93.789  1.00 46.88  ? 146  LEU C O   1 
ATOM   5441 C CB  . LEU E 2 134 ? -45.839 32.082  -91.483  1.00 28.54  ? 146  LEU C CB  1 
ATOM   5442 C CG  . LEU E 2 134 ? -44.833 31.093  -90.889  1.00 29.22  ? 146  LEU C CG  1 
ATOM   5443 C CD1 . LEU E 2 134 ? -44.465 31.471  -89.457  1.00 16.27  ? 146  LEU C CD1 1 
ATOM   5444 C CD2 . LEU E 2 134 ? -45.388 29.678  -90.946  1.00 34.09  ? 146  LEU C CD2 1 
ATOM   5445 N N   . VAL E 2 135 ? -47.271 34.199  -93.379  1.00 51.65  ? 147  VAL C N   1 
ATOM   5446 C CA  . VAL E 2 135 ? -48.502 34.904  -93.727  1.00 38.90  ? 147  VAL C CA  1 
ATOM   5447 C C   . VAL E 2 135 ? -48.795 34.784  -95.215  1.00 43.72  ? 147  VAL C C   1 
ATOM   5448 O O   . VAL E 2 135 ? -49.961 34.806  -95.629  1.00 49.88  ? 147  VAL C O   1 
ATOM   5449 C CB  . VAL E 2 135 ? -48.430 36.380  -93.290  1.00 31.06  ? 147  VAL C CB  1 
ATOM   5450 C CG1 . VAL E 2 135 ? -48.185 36.480  -91.800  1.00 45.09  ? 147  VAL C CG1 1 
ATOM   5451 C CG2 . VAL E 2 135 ? -47.344 37.123  -94.057  1.00 37.27  ? 147  VAL C CG2 1 
ATOM   5452 N N   . LYS E 2 136 ? -47.757 34.652  -96.043  1.00 42.45  ? 148  LYS C N   1 
ATOM   5453 C CA  . LYS E 2 136 ? -47.963 34.578  -97.483  1.00 49.70  ? 148  LYS C CA  1 
ATOM   5454 C C   . LYS E 2 136 ? -48.561 33.245  -97.914  1.00 58.62  ? 148  LYS C C   1 
ATOM   5455 O O   . LYS E 2 136 ? -49.131 33.166  -99.007  1.00 69.65  ? 148  LYS C O   1 
ATOM   5456 C CB  . LYS E 2 136 ? -46.642 34.827  -98.215  1.00 49.77  ? 148  LYS C CB  1 
ATOM   5457 C CG  . LYS E 2 136 ? -46.810 35.357  -99.629  1.00 58.75  ? 148  LYS C CG  1 
ATOM   5458 C CD  . LYS E 2 136 ? -46.176 36.728  -99.786  1.00 49.52  ? 148  LYS C CD  1 
ATOM   5459 C CE  . LYS E 2 136 ? -45.980 37.082  -101.253 1.00 59.26  ? 148  LYS C CE  1 
ATOM   5460 N NZ  . LYS E 2 136 ? -47.223 37.638  -101.861 1.00 79.37  ? 148  LYS C NZ  1 
ATOM   5461 N N   . THR E 2 137 ? -48.456 32.203  -97.082  1.00 54.90  ? 149  THR C N   1 
ATOM   5462 C CA  . THR E 2 137 ? -49.022 30.907  -97.442  1.00 47.45  ? 149  THR C CA  1 
ATOM   5463 C C   . THR E 2 137 ? -50.535 30.956  -97.598  1.00 60.54  ? 149  THR C C   1 
ATOM   5464 O O   . THR E 2 137 ? -51.108 30.045  -98.207  1.00 73.66  ? 149  THR C O   1 
ATOM   5465 C CB  . THR E 2 137 ? -48.653 29.841  -96.404  1.00 53.80  ? 149  THR C CB  1 
ATOM   5466 O OG1 . THR E 2 137 ? -49.599 29.864  -95.325  1.00 68.84  ? 149  THR C OG1 1 
ATOM   5467 C CG2 . THR E 2 137 ? -47.253 30.066  -95.863  1.00 50.82  ? 149  THR C CG2 1 
ATOM   5468 N N   . ASP E 2 138 ? -51.187 31.993  -97.072  1.00 63.24  ? 150  ASP C N   1 
ATOM   5469 C CA  . ASP E 2 138 ? -52.643 32.127  -97.111  1.00 65.82  ? 150  ASP C CA  1 
ATOM   5470 C C   . ASP E 2 138 ? -53.306 30.888  -96.507  1.00 80.14  ? 150  ASP C C   1 
ATOM   5471 O O   . ASP E 2 138 ? -54.082 30.178  -97.149  1.00 105.17 ? 150  ASP C O   1 
ATOM   5472 C CB  . ASP E 2 138 ? -53.128 32.386  -98.540  1.00 80.80  ? 150  ASP C CB  1 
ATOM   5473 C CG  . ASP E 2 138 ? -54.605 32.738  -98.607  1.00 113.92 ? 150  ASP C CG  1 
ATOM   5474 O OD1 . ASP E 2 138 ? -55.219 32.965  -97.540  1.00 109.27 ? 150  ASP C OD1 1 
ATOM   5475 O OD2 . ASP E 2 138 ? -55.152 32.780  -99.729  1.00 113.92 ? 150  ASP C OD2 1 
ATOM   5476 N N   . GLU E 2 139 ? -52.968 30.631  -95.245  1.00 59.48  ? 151  GLU C N   1 
ATOM   5477 C CA  . GLU E 2 139 ? -53.443 29.453  -94.535  1.00 61.36  ? 151  GLU C CA  1 
ATOM   5478 C C   . GLU E 2 139 ? -54.096 29.882  -93.232  1.00 55.47  ? 151  GLU C C   1 
ATOM   5479 O O   . GLU E 2 139 ? -53.523 30.676  -92.478  1.00 59.19  ? 151  GLU C O   1 
ATOM   5480 C CB  . GLU E 2 139 ? -52.297 28.474  -94.265  1.00 61.34  ? 151  GLU C CB  1 
ATOM   5481 C CG  . GLU E 2 139 ? -52.055 27.493  -95.401  1.00 72.01  ? 151  GLU C CG  1 
ATOM   5482 C CD  . GLU E 2 139 ? -53.018 26.319  -95.371  1.00 82.69  ? 151  GLU C CD  1 
ATOM   5483 O OE1 . GLU E 2 139 ? -54.110 26.428  -95.969  1.00 94.53  ? 151  GLU C OE1 1 
ATOM   5484 O OE2 . GLU E 2 139 ? -52.682 25.288  -94.750  1.00 68.05  ? 151  GLU C OE2 1 
ATOM   5485 N N   . GLN E 2 140 ? -55.294 29.352  -92.971  1.00 49.61  ? 152  GLN C N   1 
ATOM   5486 C CA  . GLN E 2 140 ? -56.044 29.764  -91.790  1.00 50.23  ? 152  GLN C CA  1 
ATOM   5487 C C   . GLN E 2 140 ? -55.335 29.372  -90.501  1.00 51.04  ? 152  GLN C C   1 
ATOM   5488 O O   . GLN E 2 140 ? -55.474 30.065  -89.487  1.00 66.64  ? 152  GLN C O   1 
ATOM   5489 C CB  . GLN E 2 140 ? -57.450 29.167  -91.825  1.00 73.99  ? 152  GLN C CB  1 
ATOM   5490 C CG  . GLN E 2 140 ? -58.410 29.798  -90.833  1.00 57.00  ? 152  GLN C CG  1 
ATOM   5491 C CD  . GLN E 2 140 ? -58.834 31.190  -91.252  1.00 58.80  ? 152  GLN C CD  1 
ATOM   5492 O OE1 . GLN E 2 140 ? -58.758 31.546  -92.430  1.00 47.66  ? 152  GLN C OE1 1 
ATOM   5493 N NE2 . GLN E 2 140 ? -59.286 31.985  -90.289  1.00 70.33  ? 152  GLN C NE2 1 
ATOM   5494 N N   . GLU E 2 141 ? -54.577 28.274  -90.515  1.00 47.26  ? 153  GLU C N   1 
ATOM   5495 C CA  . GLU E 2 141 ? -53.834 27.883  -89.322  1.00 60.59  ? 153  GLU C CA  1 
ATOM   5496 C C   . GLU E 2 141 ? -52.698 28.851  -89.016  1.00 56.97  ? 153  GLU C C   1 
ATOM   5497 O O   . GLU E 2 141 ? -52.278 28.948  -87.857  1.00 49.81  ? 153  GLU C O   1 
ATOM   5498 C CB  . GLU E 2 141 ? -53.300 26.454  -89.473  1.00 74.36  ? 153  GLU C CB  1 
ATOM   5499 C CG  . GLU E 2 141 ? -51.839 26.349  -89.896  1.00 72.78  ? 153  GLU C CG  1 
ATOM   5500 C CD  . GLU E 2 141 ? -51.299 24.928  -89.802  1.00 76.61  ? 153  GLU C CD  1 
ATOM   5501 O OE1 . GLU E 2 141 ? -51.468 24.290  -88.738  1.00 66.23  ? 153  GLU C OE1 1 
ATOM   5502 O OE2 . GLU E 2 141 ? -50.703 24.451  -90.792  1.00 74.29  ? 153  GLU C OE2 1 
ATOM   5503 N N   . VAL E 2 142 ? -52.202 29.575  -90.022  1.00 53.49  ? 154  VAL C N   1 
ATOM   5504 C CA  . VAL E 2 142 ? -51.207 30.609  -89.765  1.00 40.79  ? 154  VAL C CA  1 
ATOM   5505 C C   . VAL E 2 142 ? -51.864 31.847  -89.164  1.00 42.51  ? 154  VAL C C   1 
ATOM   5506 O O   . VAL E 2 142 ? -51.263 32.526  -88.322  1.00 45.13  ? 154  VAL C O   1 
ATOM   5507 C CB  . VAL E 2 142 ? -50.442 30.956  -91.054  1.00 36.82  ? 154  VAL C CB  1 
ATOM   5508 C CG1 . VAL E 2 142 ? -49.373 31.997  -90.768  1.00 36.70  ? 154  VAL C CG1 1 
ATOM   5509 C CG2 . VAL E 2 142 ? -49.829 29.705  -91.674  1.00 33.36  ? 154  VAL C CG2 1 
ATOM   5510 N N   . ILE E 2 143 ? -53.099 32.151  -89.570  1.00 47.82  ? 155  ILE C N   1 
ATOM   5511 C CA  . ILE E 2 143 ? -53.792 33.329  -89.056  1.00 42.34  ? 155  ILE C CA  1 
ATOM   5512 C C   . ILE E 2 143 ? -54.201 33.119  -87.601  1.00 45.63  ? 155  ILE C C   1 
ATOM   5513 O O   . ILE E 2 143 ? -54.034 34.012  -86.761  1.00 44.80  ? 155  ILE C O   1 
ATOM   5514 C CB  . ILE E 2 143 ? -55.003 33.667  -89.950  1.00 48.98  ? 155  ILE C CB  1 
ATOM   5515 C CG1 . ILE E 2 143 ? -54.652 34.762  -90.965  1.00 34.35  ? 155  ILE C CG1 1 
ATOM   5516 C CG2 . ILE E 2 143 ? -56.203 34.099  -89.115  1.00 52.27  ? 155  ILE C CG2 1 
ATOM   5517 C CD1 . ILE E 2 143 ? -53.461 34.447  -91.844  1.00 35.45  ? 155  ILE C CD1 1 
ATOM   5518 N N   . ASN E 2 144 ? -54.730 31.935  -87.275  1.00 53.61  ? 156  ASN C N   1 
ATOM   5519 C CA  . ASN E 2 144 ? -55.185 31.683  -85.911  1.00 45.60  ? 156  ASN C CA  1 
ATOM   5520 C C   . ASN E 2 144 ? -54.021 31.567  -84.937  1.00 51.57  ? 156  ASN C C   1 
ATOM   5521 O O   . ASN E 2 144 ? -54.178 31.879  -83.751  1.00 59.08  ? 156  ASN C O   1 
ATOM   5522 C CB  . ASN E 2 144 ? -56.041 30.419  -85.864  1.00 46.48  ? 156  ASN C CB  1 
ATOM   5523 C CG  . ASN E 2 144 ? -57.481 30.678  -86.254  1.00 56.52  ? 156  ASN C CG  1 
ATOM   5524 O OD1 . ASN E 2 144 ? -58.135 31.562  -85.698  1.00 56.02  ? 156  ASN C OD1 1 
ATOM   5525 N ND2 . ASN E 2 144 ? -57.983 29.911  -87.217  1.00 59.00  ? 156  ASN C ND2 1 
ATOM   5526 N N   . PHE E 2 145 ? -52.855 31.116  -85.410  1.00 55.49  ? 157  PHE C N   1 
ATOM   5527 C CA  . PHE E 2 145 ? -51.690 31.046  -84.533  1.00 47.89  ? 157  PHE C CA  1 
ATOM   5528 C C   . PHE E 2 145 ? -51.138 32.433  -84.242  1.00 37.66  ? 157  PHE C C   1 
ATOM   5529 O O   . PHE E 2 145 ? -50.780 32.737  -83.098  1.00 58.10  ? 157  PHE C O   1 
ATOM   5530 C CB  . PHE E 2 145 ? -50.599 30.169  -85.151  1.00 39.91  ? 157  PHE C CB  1 
ATOM   5531 C CG  . PHE E 2 145 ? -49.293 30.206  -84.395  1.00 43.12  ? 157  PHE C CG  1 
ATOM   5532 C CD1 . PHE E 2 145 ? -49.091 29.390  -83.292  1.00 57.41  ? 157  PHE C CD1 1 
ATOM   5533 C CD2 . PHE E 2 145 ? -48.272 31.060  -84.784  1.00 37.80  ? 157  PHE C CD2 1 
ATOM   5534 C CE1 . PHE E 2 145 ? -47.896 29.424  -82.595  1.00 51.73  ? 157  PHE C CE1 1 
ATOM   5535 C CE2 . PHE E 2 145 ? -47.076 31.099  -84.089  1.00 44.14  ? 157  PHE C CE2 1 
ATOM   5536 C CZ  . PHE E 2 145 ? -46.888 30.280  -82.996  1.00 35.25  ? 157  PHE C CZ  1 
ATOM   5537 N N   . LEU E 2 146 ? -51.055 33.284  -85.264  1.00 29.63  ? 158  LEU C N   1 
ATOM   5538 C CA  . LEU E 2 146 ? -50.413 34.580  -85.086  1.00 40.79  ? 158  LEU C CA  1 
ATOM   5539 C C   . LEU E 2 146 ? -51.232 35.491  -84.179  1.00 42.42  ? 158  LEU C C   1 
ATOM   5540 O O   . LEU E 2 146 ? -50.674 36.163  -83.303  1.00 60.28  ? 158  LEU C O   1 
ATOM   5541 C CB  . LEU E 2 146 ? -50.173 35.231  -86.446  1.00 34.95  ? 158  LEU C CB  1 
ATOM   5542 C CG  . LEU E 2 146 ? -49.017 34.632  -87.251  1.00 29.81  ? 158  LEU C CG  1 
ATOM   5543 C CD1 . LEU E 2 146 ? -48.717 35.489  -88.459  1.00 29.22  ? 158  LEU C CD1 1 
ATOM   5544 C CD2 . LEU E 2 146 ? -47.772 34.480  -86.384  1.00 34.94  ? 158  LEU C CD2 1 
ATOM   5545 N N   . LEU E 2 147 ? -52.555 35.510  -84.357  1.00 36.72  ? 159  LEU C N   1 
ATOM   5546 C CA  . LEU E 2 147 ? -53.396 36.432  -83.597  1.00 44.69  ? 159  LEU C CA  1 
ATOM   5547 C C   . LEU E 2 147 ? -53.211 36.249  -82.094  1.00 49.96  ? 159  LEU C C   1 
ATOM   5548 O O   . LEU E 2 147 ? -52.946 37.213  -81.365  1.00 44.39  ? 159  LEU C O   1 
ATOM   5549 C CB  . LEU E 2 147 ? -54.862 36.236  -83.981  1.00 34.71  ? 159  LEU C CB  1 
ATOM   5550 C CG  . LEU E 2 147 ? -55.243 36.611  -85.412  1.00 28.20  ? 159  LEU C CG  1 
ATOM   5551 C CD1 . LEU E 2 147 ? -56.612 36.044  -85.759  1.00 34.63  ? 159  LEU C CD1 1 
ATOM   5552 C CD2 . LEU E 2 147 ? -55.212 38.119  -85.598  1.00 36.87  ? 159  LEU C CD2 1 
ATOM   5553 N N   . THR E 2 148 ? -53.331 35.015  -81.614  1.00 38.76  ? 160  THR C N   1 
ATOM   5554 C CA  . THR E 2 148 ? -53.331 34.764  -80.179  1.00 53.71  ? 160  THR C CA  1 
ATOM   5555 C C   . THR E 2 148 ? -51.934 34.730  -79.569  1.00 54.72  ? 160  THR C C   1 
ATOM   5556 O O   . THR E 2 148 ? -51.820 34.576  -78.347  1.00 70.01  ? 160  THR C O   1 
ATOM   5557 C CB  . THR E 2 148 ? -54.054 33.449  -79.880  1.00 64.08  ? 160  THR C CB  1 
ATOM   5558 O OG1 . THR E 2 148 ? -53.142 32.358  -80.041  1.00 56.82  ? 160  THR C OG1 1 
ATOM   5559 C CG2 . THR E 2 148 ? -55.238 33.264  -80.827  1.00 47.32  ? 160  THR C CG2 1 
ATOM   5560 N N   . THR E 2 149 ? -50.878 34.866  -80.370  1.00 45.61  ? 161  THR C N   1 
ATOM   5561 C CA  . THR E 2 149 ? -49.514 34.907  -79.856  1.00 53.79  ? 161  THR C CA  1 
ATOM   5562 C C   . THR E 2 149 ? -48.971 36.327  -79.749  1.00 59.99  ? 161  THR C C   1 
ATOM   5563 O O   . THR E 2 149 ? -47.786 36.504  -79.449  1.00 66.52  ? 161  THR C O   1 
ATOM   5564 C CB  . THR E 2 149 ? -48.583 34.056  -80.726  1.00 39.64  ? 161  THR C CB  1 
ATOM   5565 O OG1 . THR E 2 149 ? -48.838 34.318  -82.111  1.00 44.10  ? 161  THR C OG1 1 
ATOM   5566 C CG2 . THR E 2 149 ? -48.789 32.571  -80.441  1.00 33.67  ? 161  THR C CG2 1 
ATOM   5567 N N   . GLU E 2 150 ? -49.812 37.336  -79.987  1.00 51.86  ? 162  GLU C N   1 
ATOM   5568 C CA  . GLU E 2 150 ? -49.440 38.744  -79.826  1.00 55.83  ? 162  GLU C CA  1 
ATOM   5569 C C   . GLU E 2 150 ? -48.307 39.141  -80.770  1.00 54.98  ? 162  GLU C C   1 
ATOM   5570 O O   . GLU E 2 150 ? -47.364 39.834  -80.380  1.00 51.46  ? 162  GLU C O   1 
ATOM   5571 C CB  . GLU E 2 150 ? -49.069 39.064  -78.374  1.00 61.08  ? 162  GLU C CB  1 
ATOM   5572 C CG  . GLU E 2 150 ? -50.058 38.551  -77.337  1.00 72.49  ? 162  GLU C CG  1 
ATOM   5573 C CD  . GLU E 2 150 ? -49.381 37.766  -76.228  1.00 88.36  ? 162  GLU C CD  1 
ATOM   5574 O OE1 . GLU E 2 150 ? -48.136 37.820  -76.134  1.00 83.14  ? 162  GLU C OE1 1 
ATOM   5575 O OE2 . GLU E 2 150 ? -50.094 37.098  -75.448  1.00 96.86  ? 162  GLU C OE2 1 
ATOM   5576 N N   . ILE E 2 151 ? -48.397 38.702  -82.028  1.00 51.10  ? 163  ILE C N   1 
ATOM   5577 C CA  . ILE E 2 151 ? -47.443 39.182  -83.022  1.00 50.75  ? 163  ILE C CA  1 
ATOM   5578 C C   . ILE E 2 151 ? -47.773 40.618  -83.399  1.00 54.29  ? 163  ILE C C   1 
ATOM   5579 O O   . ILE E 2 151 ? -46.872 41.425  -83.660  1.00 62.23  ? 163  ILE C O   1 
ATOM   5580 C CB  . ILE E 2 151 ? -47.429 38.266  -84.260  1.00 45.45  ? 163  ILE C CB  1 
ATOM   5581 C CG1 . ILE E 2 151 ? -46.571 38.869  -85.373  1.00 50.54  ? 163  ILE C CG1 1 
ATOM   5582 C CG2 . ILE E 2 151 ? -48.832 38.083  -84.793  1.00 40.44  ? 163  ILE C CG2 1 
ATOM   5583 C CD1 . ILE E 2 151 ? -45.080 38.687  -85.165  1.00 45.45  ? 163  ILE C CD1 1 
ATOM   5584 N N   . ILE E 2 152 ? -49.064 40.968  -83.415  1.00 46.25  ? 164  ILE C N   1 
ATOM   5585 C CA  . ILE E 2 152 ? -49.465 42.321  -83.803  1.00 38.39  ? 164  ILE C CA  1 
ATOM   5586 C C   . ILE E 2 152 ? -48.856 43.375  -82.886  1.00 45.44  ? 164  ILE C C   1 
ATOM   5587 O O   . ILE E 2 152 ? -48.345 44.382  -83.397  1.00 58.31  ? 164  ILE C O   1 
ATOM   5588 C CB  . ILE E 2 152 ? -50.988 42.417  -83.908  1.00 36.21  ? 164  ILE C CB  1 
ATOM   5589 C CG1 . ILE E 2 152 ? -51.537 41.227  -84.698  1.00 49.29  ? 164  ILE C CG1 1 
ATOM   5590 C CG2 . ILE E 2 152 ? -51.391 43.729  -84.563  1.00 29.86  ? 164  ILE C CG2 1 
ATOM   5591 C CD1 . ILE E 2 152 ? -53.027 41.277  -84.928  1.00 44.94  ? 164  ILE C CD1 1 
ATOM   5592 N N   . PRO E 2 153 ? -48.873 43.233  -81.553  1.00 42.64  ? 165  PRO C N   1 
ATOM   5593 C CA  . PRO E 2 153 ? -48.151 44.221  -80.732  1.00 42.31  ? 165  PRO C CA  1 
ATOM   5594 C C   . PRO E 2 153 ? -46.680 44.327  -81.090  1.00 47.51  ? 165  PRO C C   1 
ATOM   5595 O O   . PRO E 2 153 ? -46.127 45.434  -81.094  1.00 61.63  ? 165  PRO C O   1 
ATOM   5596 C CB  . PRO E 2 153 ? -48.363 43.706  -79.303  1.00 42.86  ? 165  PRO C CB  1 
ATOM   5597 C CG  . PRO E 2 153 ? -49.654 42.984  -79.366  1.00 54.86  ? 165  PRO C CG  1 
ATOM   5598 C CD  . PRO E 2 153 ? -49.668 42.316  -80.713  1.00 56.54  ? 165  PRO C CD  1 
ATOM   5599 N N   . LEU E 2 154 ? -46.030 43.204  -81.405  1.00 55.57  ? 166  LEU C N   1 
ATOM   5600 C CA  . LEU E 2 154 ? -44.640 43.257  -81.848  1.00 64.41  ? 166  LEU C CA  1 
ATOM   5601 C C   . LEU E 2 154 ? -44.517 44.024  -83.160  1.00 57.39  ? 166  LEU C C   1 
ATOM   5602 O O   . LEU E 2 154 ? -43.634 44.875  -83.313  1.00 61.09  ? 166  LEU C O   1 
ATOM   5603 C CB  . LEU E 2 154 ? -44.074 41.842  -81.991  1.00 49.37  ? 166  LEU C CB  1 
ATOM   5604 C CG  . LEU E 2 154 ? -43.814 41.085  -80.687  1.00 44.70  ? 166  LEU C CG  1 
ATOM   5605 C CD1 . LEU E 2 154 ? -43.668 39.593  -80.948  1.00 35.64  ? 166  LEU C CD1 1 
ATOM   5606 C CD2 . LEU E 2 154 ? -42.581 41.638  -79.986  1.00 32.09  ? 166  LEU C CD2 1 
ATOM   5607 N N   . CYS E 2 155 ? -45.411 43.745  -84.112  1.00 55.67  ? 167  CYS C N   1 
ATOM   5608 C CA  . CYS E 2 155 ? -45.362 44.416  -85.409  1.00 38.64  ? 167  CYS C CA  1 
ATOM   5609 C C   . CYS E 2 155 ? -45.501 45.927  -85.259  1.00 54.12  ? 167  CYS C C   1 
ATOM   5610 O O   . CYS E 2 155 ? -44.672 46.690  -85.768  1.00 58.03  ? 167  CYS C O   1 
ATOM   5611 C CB  . CYS E 2 155 ? -46.455 43.865  -86.327  1.00 43.40  ? 167  CYS C CB  1 
ATOM   5612 S SG  . CYS E 2 155 ? -46.197 42.164  -86.886  1.00 54.07  ? 167  CYS C SG  1 
ATOM   5613 N N   . LEU E 2 156 ? -46.545 46.378  -84.553  1.00 61.12  ? 168  LEU C N   1 
ATOM   5614 C CA  . LEU E 2 156 ? -46.796 47.810  -84.400  1.00 48.47  ? 168  LEU C CA  1 
ATOM   5615 C C   . LEU E 2 156 ? -45.631 48.539  -83.744  1.00 45.50  ? 168  LEU C C   1 
ATOM   5616 O O   . LEU E 2 156 ? -45.471 49.746  -83.955  1.00 50.09  ? 168  LEU C O   1 
ATOM   5617 C CB  . LEU E 2 156 ? -48.078 48.042  -83.599  1.00 45.43  ? 168  LEU C CB  1 
ATOM   5618 C CG  . LEU E 2 156 ? -49.345 47.307  -84.047  1.00 46.43  ? 168  LEU C CG  1 
ATOM   5619 C CD1 . LEU E 2 156 ? -50.576 47.897  -83.378  1.00 54.93  ? 168  LEU C CD1 1 
ATOM   5620 C CD2 . LEU E 2 156 ? -49.496 47.334  -85.561  1.00 43.43  ? 168  LEU C CD2 1 
ATOM   5621 N N   . ARG E 2 157 ? -44.814 47.840  -82.955  1.00 44.74  ? 169  ARG C N   1 
ATOM   5622 C CA  . ARG E 2 157 ? -43.582 48.446  -82.462  1.00 56.06  ? 169  ARG C CA  1 
ATOM   5623 C C   . ARG E 2 157 ? -42.601 48.696  -83.603  1.00 60.34  ? 169  ARG C C   1 
ATOM   5624 O O   . ARG E 2 157 ? -41.970 49.758  -83.664  1.00 65.49  ? 169  ARG C O   1 
ATOM   5625 C CB  . ARG E 2 157 ? -42.955 47.554  -81.389  1.00 62.92  ? 169  ARG C CB  1 
ATOM   5626 C CG  . ARG E 2 157 ? -41.458 47.752  -81.192  1.00 70.02  ? 169  ARG C CG  1 
ATOM   5627 C CD  . ARG E 2 157 ? -40.959 47.000  -79.965  1.00 78.90  ? 169  ARG C CD  1 
ATOM   5628 N NE  . ARG E 2 157 ? -41.108 47.784  -78.745  1.00 84.37  ? 169  ARG C NE  1 
ATOM   5629 C CZ  . ARG E 2 157 ? -42.005 47.537  -77.799  1.00 90.98  ? 169  ARG C CZ  1 
ATOM   5630 N NH1 . ARG E 2 157 ? -42.852 46.524  -77.896  1.00 81.41  ? 169  ARG C NH1 1 
ATOM   5631 N NH2 . ARG E 2 157 ? -42.054 48.326  -76.730  1.00 87.02  ? 169  ARG C NH2 1 
ATOM   5632 N N   . ILE E 2 158 ? -42.473 47.737  -84.526  1.00 49.75  ? 170  ILE C N   1 
ATOM   5633 C CA  . ILE E 2 158 ? -41.544 47.893  -85.644  1.00 53.61  ? 170  ILE C CA  1 
ATOM   5634 C C   . ILE E 2 158 ? -42.077 48.908  -86.648  1.00 56.21  ? 170  ILE C C   1 
ATOM   5635 O O   . ILE E 2 158 ? -41.323 49.742  -87.167  1.00 56.65  ? 170  ILE C O   1 
ATOM   5636 C CB  . ILE E 2 158 ? -41.264 46.532  -86.312  1.00 54.13  ? 170  ILE C CB  1 
ATOM   5637 C CG1 . ILE E 2 158 ? -40.215 45.744  -85.533  1.00 59.44  ? 170  ILE C CG1 1 
ATOM   5638 C CG2 . ILE E 2 158 ? -40.793 46.716  -87.736  1.00 51.06  ? 170  ILE C CG2 1 
ATOM   5639 C CD1 . ILE E 2 158 ? -40.774 44.991  -84.386  1.00 62.35  ? 170  ILE C CD1 1 
ATOM   5640 N N   . MET E 2 159 ? -43.380 48.854  -86.943  1.00 55.99  ? 171  MET C N   1 
ATOM   5641 C CA  . MET E 2 159 ? -43.974 49.820  -87.863  1.00 49.81  ? 171  MET C CA  1 
ATOM   5642 C C   . MET E 2 159 ? -43.812 51.249  -87.361  1.00 50.57  ? 171  MET C C   1 
ATOM   5643 O O   . MET E 2 159 ? -43.790 52.190  -88.162  1.00 57.00  ? 171  MET C O   1 
ATOM   5644 C CB  . MET E 2 159 ? -45.454 49.499  -88.084  1.00 45.26  ? 171  MET C CB  1 
ATOM   5645 C CG  . MET E 2 159 ? -45.742 48.029  -88.369  1.00 57.83  ? 171  MET C CG  1 
ATOM   5646 S SD  . MET E 2 159 ? -47.485 47.622  -88.634  1.00 57.27  ? 171  MET C SD  1 
ATOM   5647 C CE  . MET E 2 159 ? -48.230 49.251  -88.660  1.00 48.09  ? 171  MET C CE  1 
ATOM   5648 N N   . GLU E 2 160 ? -43.685 51.431  -86.049  1.00 50.72  ? 172  GLU C N   1 
ATOM   5649 C CA  . GLU E 2 160 ? -43.546 52.759  -85.467  1.00 48.30  ? 172  GLU C CA  1 
ATOM   5650 C C   . GLU E 2 160 ? -42.103 53.248  -85.459  1.00 50.33  ? 172  GLU C C   1 
ATOM   5651 O O   . GLU E 2 160 ? -41.840 54.397  -85.830  1.00 70.52  ? 172  GLU C O   1 
ATOM   5652 C CB  . GLU E 2 160 ? -44.101 52.767  -84.042  1.00 65.47  ? 172  GLU C CB  1 
ATOM   5653 C CG  . GLU E 2 160 ? -44.411 54.153  -83.499  1.00 59.14  ? 172  GLU C CG  1 
ATOM   5654 C CD  . GLU E 2 160 ? -45.008 54.108  -82.106  1.00 69.34  ? 172  GLU C CD  1 
ATOM   5655 O OE1 . GLU E 2 160 ? -45.070 53.006  -81.520  1.00 68.06  ? 172  GLU C OE1 1 
ATOM   5656 O OE2 . GLU E 2 160 ? -45.426 55.171  -81.601  1.00 84.96  ? 172  GLU C OE2 1 
ATOM   5657 N N   . SER E 2 161 ? -41.155 52.396  -85.046  1.00 57.92  ? 173  SER C N   1 
ATOM   5658 C CA  . SER E 2 161 ? -39.766 52.810  -84.827  1.00 61.51  ? 173  SER C CA  1 
ATOM   5659 C C   . SER E 2 161 ? -38.825 51.723  -85.360  1.00 56.96  ? 173  SER C C   1 
ATOM   5660 O O   . SER E 2 161 ? -38.315 50.881  -84.617  1.00 64.51  ? 173  SER C O   1 
ATOM   5661 C CB  . SER E 2 161 ? -39.517 53.098  -83.349  1.00 65.20  ? 173  SER C CB  1 
ATOM   5662 O OG  . SER E 2 161 ? -40.163 52.132  -82.537  1.00 70.72  ? 173  SER C OG  1 
ATOM   5663 N N   . GLY E 2 162 ? -38.580 51.756  -86.665  1.00 43.75  ? 174  GLY C N   1 
ATOM   5664 C CA  . GLY E 2 162 ? -37.653 50.822  -87.274  1.00 48.60  ? 174  GLY C CA  1 
ATOM   5665 C C   . GLY E 2 162 ? -37.265 51.303  -88.652  1.00 63.38  ? 174  GLY C C   1 
ATOM   5666 O O   . GLY E 2 162 ? -37.820 52.272  -89.176  1.00 61.27  ? 174  GLY C O   1 
ATOM   5667 N N   . SER E 2 163 ? -36.288 50.610  -89.236  1.00 59.53  ? 175  SER C N   1 
ATOM   5668 C CA  . SER E 2 163 ? -35.860 50.936  -90.588  1.00 54.46  ? 175  SER C CA  1 
ATOM   5669 C C   . SER E 2 163 ? -37.022 50.768  -91.559  1.00 62.18  ? 175  SER C C   1 
ATOM   5670 O O   . SER E 2 163 ? -37.960 50.004  -91.315  1.00 69.83  ? 175  SER C O   1 
ATOM   5671 C CB  . SER E 2 163 ? -34.687 50.054  -91.012  1.00 59.78  ? 175  SER C CB  1 
ATOM   5672 O OG  . SER E 2 163 ? -34.877 48.716  -90.592  1.00 71.25  ? 175  SER C OG  1 
ATOM   5673 N N   . GLU E 2 164 ? -36.952 51.500  -92.674  1.00 68.94  ? 176  GLU C N   1 
ATOM   5674 C CA  . GLU E 2 164 ? -38.071 51.535  -93.610  1.00 59.85  ? 176  GLU C CA  1 
ATOM   5675 C C   . GLU E 2 164 ? -38.402 50.148  -94.149  1.00 56.14  ? 176  GLU C C   1 
ATOM   5676 O O   . GLU E 2 164 ? -39.572 49.851  -94.420  1.00 64.07  ? 176  GLU C O   1 
ATOM   5677 C CB  . GLU E 2 164 ? -37.759 52.508  -94.747  1.00 68.21  ? 176  GLU C CB  1 
ATOM   5678 C CG  . GLU E 2 164 ? -38.684 52.407  -95.938  1.00 76.09  ? 176  GLU C CG  1 
ATOM   5679 C CD  . GLU E 2 164 ? -37.979 51.857  -97.156  1.00 98.42  ? 176  GLU C CD  1 
ATOM   5680 O OE1 . GLU E 2 164 ? -36.739 51.991  -97.236  1.00 104.07 ? 176  GLU C OE1 1 
ATOM   5681 O OE2 . GLU E 2 164 ? -38.663 51.284  -98.029  1.00 99.17  ? 176  GLU C OE2 1 
ATOM   5682 N N   . LEU E 2 165 ? -37.397 49.279  -94.291  1.00 51.43  ? 177  LEU C N   1 
ATOM   5683 C CA  . LEU E 2 165 ? -37.675 47.901  -94.688  1.00 54.38  ? 177  LEU C CA  1 
ATOM   5684 C C   . LEU E 2 165 ? -38.368 47.132  -93.570  1.00 50.39  ? 177  LEU C C   1 
ATOM   5685 O O   . LEU E 2 165 ? -39.318 46.382  -93.824  1.00 53.72  ? 177  LEU C O   1 
ATOM   5686 C CB  . LEU E 2 165 ? -36.387 47.194  -95.100  1.00 38.18  ? 177  LEU C CB  1 
ATOM   5687 C CG  . LEU E 2 165 ? -36.589 45.830  -95.763  1.00 34.76  ? 177  LEU C CG  1 
ATOM   5688 C CD1 . LEU E 2 165 ? -37.566 45.923  -96.932  1.00 26.05  ? 177  LEU C CD1 1 
ATOM   5689 C CD2 . LEU E 2 165 ? -35.257 45.257  -96.209  1.00 42.49  ? 177  LEU C CD2 1 
ATOM   5690 N N   . SER E 2 166 ? -37.900 47.295  -92.329  1.00 45.80  ? 178  SER C N   1 
ATOM   5691 C CA  . SER E 2 166 ? -38.578 46.668  -91.199  1.00 44.53  ? 178  SER C CA  1 
ATOM   5692 C C   . SER E 2 166 ? -40.024 47.132  -91.107  1.00 52.71  ? 178  SER C C   1 
ATOM   5693 O O   . SER E 2 166 ? -40.925 46.331  -90.830  1.00 62.86  ? 178  SER C O   1 
ATOM   5694 C CB  . SER E 2 166 ? -37.834 46.973  -89.898  1.00 48.70  ? 178  SER C CB  1 
ATOM   5695 O OG  . SER E 2 166 ? -36.588 46.300  -89.842  1.00 67.87  ? 178  SER C OG  1 
ATOM   5696 N N   . LYS E 2 167 ? -40.266 48.425  -91.346  1.00 50.88  ? 179  LYS C N   1 
ATOM   5697 C CA  . LYS E 2 167 ? -41.632 48.936  -91.348  1.00 42.53  ? 179  LYS C CA  1 
ATOM   5698 C C   . LYS E 2 167 ? -42.446 48.320  -92.478  1.00 46.09  ? 179  LYS C C   1 
ATOM   5699 O O   . LYS E 2 167 ? -43.617 47.970  -92.290  1.00 47.45  ? 179  LYS C O   1 
ATOM   5700 C CB  . LYS E 2 167 ? -41.624 50.461  -91.467  1.00 42.37  ? 179  LYS C CB  1 
ATOM   5701 C CG  . LYS E 2 167 ? -40.902 51.184  -90.337  1.00 47.20  ? 179  LYS C CG  1 
ATOM   5702 C CD  . LYS E 2 167 ? -40.660 52.646  -90.692  1.00 49.64  ? 179  LYS C CD  1 
ATOM   5703 C CE  . LYS E 2 167 ? -40.895 53.558  -89.499  1.00 44.63  ? 179  LYS C CE  1 
ATOM   5704 N NZ  . LYS E 2 167 ? -41.810 54.685  -89.843  1.00 50.69  ? 179  LYS C NZ  1 
ATOM   5705 N N   . THR E 2 168 ? -41.838 48.174  -93.659  1.00 54.73  ? 180  THR C N   1 
ATOM   5706 C CA  . THR E 2 168 ? -42.567 47.646  -94.809  1.00 50.50  ? 180  THR C CA  1 
ATOM   5707 C C   . THR E 2 168 ? -42.897 46.169  -94.631  1.00 54.46  ? 180  THR C C   1 
ATOM   5708 O O   . THR E 2 168 ? -44.003 45.731  -94.967  1.00 61.26  ? 180  THR C O   1 
ATOM   5709 C CB  . THR E 2 168 ? -41.759 47.861  -96.090  1.00 49.62  ? 180  THR C CB  1 
ATOM   5710 O OG1 . THR E 2 168 ? -41.121 49.144  -96.046  1.00 48.10  ? 180  THR C OG1 1 
ATOM   5711 C CG2 . THR E 2 168 ? -42.671 47.795  -97.312  1.00 51.62  ? 180  THR C CG2 1 
ATOM   5712 N N   . VAL E 2 169 ? -41.951 45.385  -94.110  1.00 48.90  ? 181  VAL C N   1 
ATOM   5713 C CA  . VAL E 2 169 ? -42.216 43.969  -93.877  1.00 44.26  ? 181  VAL C CA  1 
ATOM   5714 C C   . VAL E 2 169 ? -43.269 43.795  -92.789  1.00 46.69  ? 181  VAL C C   1 
ATOM   5715 O O   . VAL E 2 169 ? -44.145 42.927  -92.888  1.00 52.23  ? 181  VAL C O   1 
ATOM   5716 C CB  . VAL E 2 169 ? -40.913 43.226  -93.530  1.00 36.33  ? 181  VAL C CB  1 
ATOM   5717 C CG1 . VAL E 2 169 ? -41.199 41.762  -93.240  1.00 34.40  ? 181  VAL C CG1 1 
ATOM   5718 C CG2 . VAL E 2 169 ? -39.909 43.352  -94.667  1.00 35.42  ? 181  VAL C CG2 1 
ATOM   5719 N N   . ALA E 2 170 ? -43.212 44.626  -91.745  1.00 50.68  ? 182  ALA C N   1 
ATOM   5720 C CA  . ALA E 2 170 ? -44.165 44.501  -90.645  1.00 44.10  ? 182  ALA C CA  1 
ATOM   5721 C C   . ALA E 2 170 ? -45.567 44.927  -91.067  1.00 44.83  ? 182  ALA C C   1 
ATOM   5722 O O   . ALA E 2 170 ? -46.550 44.249  -90.742  1.00 40.21  ? 182  ALA C O   1 
ATOM   5723 C CB  . ALA E 2 170 ? -43.690 45.319  -89.446  1.00 40.44  ? 182  ALA C CB  1 
ATOM   5724 N N   . THR E 2 171 ? -45.684 46.048  -91.786  1.00 46.43  ? 183  THR C N   1 
ATOM   5725 C CA  . THR E 2 171 ? -46.990 46.464  -92.289  1.00 35.69  ? 183  THR C CA  1 
ATOM   5726 C C   . THR E 2 171 ? -47.567 45.433  -93.249  1.00 40.83  ? 183  THR C C   1 
ATOM   5727 O O   . THR E 2 171 ? -48.791 45.278  -93.327  1.00 50.37  ? 183  THR C O   1 
ATOM   5728 C CB  . THR E 2 171 ? -46.890 47.826  -92.978  1.00 32.18  ? 183  THR C CB  1 
ATOM   5729 O OG1 . THR E 2 171 ? -46.079 48.706  -92.189  1.00 47.94  ? 183  THR C OG1 1 
ATOM   5730 C CG2 . THR E 2 171 ? -48.274 48.441  -93.148  1.00 40.15  ? 183  THR C CG2 1 
ATOM   5731 N N   . PHE E 2 172 ? -46.703 44.721  -93.981  1.00 45.53  ? 184  PHE C N   1 
ATOM   5732 C CA  . PHE E 2 172 ? -47.165 43.647  -94.858  1.00 46.81  ? 184  PHE C CA  1 
ATOM   5733 C C   . PHE E 2 172 ? -47.752 42.491  -94.055  1.00 52.28  ? 184  PHE C C   1 
ATOM   5734 O O   . PHE E 2 172 ? -48.746 41.882  -94.468  1.00 56.29  ? 184  PHE C O   1 
ATOM   5735 C CB  . PHE E 2 172 ? -46.011 43.163  -95.742  1.00 41.64  ? 184  PHE C CB  1 
ATOM   5736 C CG  . PHE E 2 172 ? -46.286 41.866  -96.461  1.00 51.91  ? 184  PHE C CG  1 
ATOM   5737 C CD1 . PHE E 2 172 ? -47.021 41.850  -97.637  1.00 57.24  ? 184  PHE C CD1 1 
ATOM   5738 C CD2 . PHE E 2 172 ? -45.796 40.664  -95.969  1.00 44.12  ? 184  PHE C CD2 1 
ATOM   5739 C CE1 . PHE E 2 172 ? -47.272 40.660  -98.302  1.00 51.25  ? 184  PHE C CE1 1 
ATOM   5740 C CE2 . PHE E 2 172 ? -46.044 39.472  -96.629  1.00 46.52  ? 184  PHE C CE2 1 
ATOM   5741 C CZ  . PHE E 2 172 ? -46.783 39.471  -97.797  1.00 43.86  ? 184  PHE C CZ  1 
ATOM   5742 N N   . ILE E 2 173 ? -47.146 42.168  -92.911  1.00 48.11  ? 185  ILE C N   1 
ATOM   5743 C CA  . ILE E 2 173 ? -47.690 41.123  -92.049  1.00 40.53  ? 185  ILE C CA  1 
ATOM   5744 C C   . ILE E 2 173 ? -49.027 41.564  -91.467  1.00 47.57  ? 185  ILE C C   1 
ATOM   5745 O O   . ILE E 2 173 ? -50.010 40.813  -91.482  1.00 44.89  ? 185  ILE C O   1 
ATOM   5746 C CB  . ILE E 2 173 ? -46.682 40.763  -90.942  1.00 38.49  ? 185  ILE C CB  1 
ATOM   5747 C CG1 . ILE E 2 173 ? -45.474 40.033  -91.533  1.00 28.64  ? 185  ILE C CG1 1 
ATOM   5748 C CG2 . ILE E 2 173 ? -47.344 39.916  -89.863  1.00 44.59  ? 185  ILE C CG2 1 
ATOM   5749 C CD1 . ILE E 2 173 ? -44.335 39.850  -90.555  1.00 23.67  ? 185  ILE C CD1 1 
ATOM   5750 N N   . LEU E 2 174 ? -49.081 42.797  -90.950  1.00 45.71  ? 186  LEU C N   1 
ATOM   5751 C CA  . LEU E 2 174 ? -50.328 43.345  -90.428  1.00 36.85  ? 186  LEU C CA  1 
ATOM   5752 C C   . LEU E 2 174 ? -51.374 43.481  -91.527  1.00 43.61  ? 186  LEU C C   1 
ATOM   5753 O O   . LEU E 2 174 ? -52.577 43.387  -91.256  1.00 39.76  ? 186  LEU C O   1 
ATOM   5754 C CB  . LEU E 2 174 ? -50.047 44.692  -89.756  1.00 35.36  ? 186  LEU C CB  1 
ATOM   5755 C CG  . LEU E 2 174 ? -51.123 45.395  -88.927  1.00 29.72  ? 186  LEU C CG  1 
ATOM   5756 C CD1 . LEU E 2 174 ? -52.040 46.234  -89.796  1.00 38.42  ? 186  LEU C CD1 1 
ATOM   5757 C CD2 . LEU E 2 174 ? -51.921 44.371  -88.141  1.00 35.98  ? 186  LEU C CD2 1 
ATOM   5758 N N   . GLN E 2 175 ? -50.932 43.699  -92.767  1.00 49.48  ? 187  GLN C N   1 
ATOM   5759 C CA  . GLN E 2 175 ? -51.800 43.704  -93.938  1.00 38.59  ? 187  GLN C CA  1 
ATOM   5760 C C   . GLN E 2 175 ? -52.455 42.341  -94.126  1.00 48.38  ? 187  GLN C C   1 
ATOM   5761 O O   . GLN E 2 175 ? -53.679 42.215  -94.011  1.00 59.06  ? 187  GLN C O   1 
ATOM   5762 C CB  . GLN E 2 175 ? -50.994 44.084  -95.183  1.00 46.47  ? 187  GLN C CB  1 
ATOM   5763 C CG  . GLN E 2 175 ? -51.764 44.816  -96.266  1.00 59.84  ? 187  GLN C CG  1 
ATOM   5764 C CD  . GLN E 2 175 ? -50.992 44.880  -97.572  1.00 53.46  ? 187  GLN C CD  1 
ATOM   5765 O OE1 . GLN E 2 175 ? -51.317 45.665  -98.464  1.00 60.53  ? 187  GLN C OE1 1 
ATOM   5766 N NE2 . GLN E 2 175 ? -49.961 44.048  -97.691  1.00 52.51  ? 187  GLN C NE2 1 
ATOM   5767 N N   . LYS E 2 176 ? -51.641 41.315  -94.400  1.00 50.84  ? 188  LYS C N   1 
ATOM   5768 C CA  . LYS E 2 176 ? -52.168 39.978  -94.670  1.00 48.07  ? 188  LYS C CA  1 
ATOM   5769 C C   . LYS E 2 176 ? -53.087 39.497  -93.553  1.00 47.84  ? 188  LYS C C   1 
ATOM   5770 O O   . LYS E 2 176 ? -54.096 38.831  -93.812  1.00 61.10  ? 188  LYS C O   1 
ATOM   5771 C CB  . LYS E 2 176 ? -51.015 38.990  -94.871  1.00 39.01  ? 188  LYS C CB  1 
ATOM   5772 C CG  . LYS E 2 176 ? -50.064 39.340  -96.010  1.00 39.90  ? 188  LYS C CG  1 
ATOM   5773 C CD  . LYS E 2 176 ? -50.809 39.746  -97.276  1.00 50.68  ? 188  LYS C CD  1 
ATOM   5774 C CE  . LYS E 2 176 ? -50.389 38.894  -98.468  1.00 46.04  ? 188  LYS C CE  1 
ATOM   5775 N NZ  . LYS E 2 176 ? -50.759 39.530  -99.767  1.00 38.53  ? 188  LYS C NZ  1 
ATOM   5776 N N   . ILE E 2 177 ? -52.754 39.826  -92.303  1.00 44.02  ? 189  ILE C N   1 
ATOM   5777 C CA  . ILE E 2 177 ? -53.611 39.451  -91.181  1.00 45.20  ? 189  ILE C CA  1 
ATOM   5778 C C   . ILE E 2 177 ? -54.957 40.159  -91.279  1.00 46.74  ? 189  ILE C C   1 
ATOM   5779 O O   . ILE E 2 177 ? -56.015 39.549  -91.082  1.00 44.58  ? 189  ILE C O   1 
ATOM   5780 C CB  . ILE E 2 177 ? -52.904 39.756  -89.847  1.00 41.10  ? 189  ILE C CB  1 
ATOM   5781 C CG1 . ILE E 2 177 ? -51.767 38.757  -89.609  1.00 40.56  ? 189  ILE C CG1 1 
ATOM   5782 C CG2 . ILE E 2 177 ? -53.904 39.745  -88.691  1.00 38.96  ? 189  ILE C CG2 1 
ATOM   5783 C CD1 . ILE E 2 177 ? -50.931 39.048  -88.376  1.00 24.74  ? 189  ILE C CD1 1 
ATOM   5784 N N   . LEU E 2 178 ? -54.938 41.456  -91.595  1.00 47.23  ? 190  LEU C N   1 
ATOM   5785 C CA  . LEU E 2 178 ? -56.181 42.213  -91.701  1.00 34.56  ? 190  LEU C CA  1 
ATOM   5786 C C   . LEU E 2 178 ? -57.033 41.727  -92.866  1.00 47.45  ? 190  LEU C C   1 
ATOM   5787 O O   . LEU E 2 178 ? -58.264 41.667  -92.759  1.00 56.84  ? 190  LEU C O   1 
ATOM   5788 C CB  . LEU E 2 178 ? -55.881 43.703  -91.853  1.00 23.59  ? 190  LEU C CB  1 
ATOM   5789 C CG  . LEU E 2 178 ? -55.782 44.529  -90.571  1.00 32.57  ? 190  LEU C CG  1 
ATOM   5790 C CD1 . LEU E 2 178 ? -55.401 45.959  -90.901  1.00 33.29  ? 190  LEU C CD1 1 
ATOM   5791 C CD2 . LEU E 2 178 ? -57.090 44.491  -89.805  1.00 46.00  ? 190  LEU C CD2 1 
ATOM   5792 N N   . LEU E 2 179 ? -56.400 41.381  -93.991  1.00 47.04  ? 191  LEU C N   1 
ATOM   5793 C CA  . LEU E 2 179 ? -57.155 40.960  -95.166  1.00 45.86  ? 191  LEU C CA  1 
ATOM   5794 C C   . LEU E 2 179 ? -57.861 39.625  -94.966  1.00 47.53  ? 191  LEU C C   1 
ATOM   5795 O O   . LEU E 2 179 ? -58.778 39.306  -95.731  1.00 59.40  ? 191  LEU C O   1 
ATOM   5796 C CB  . LEU E 2 179 ? -56.246 40.901  -96.394  1.00 43.26  ? 191  LEU C CB  1 
ATOM   5797 C CG  . LEU E 2 179 ? -56.107 42.222  -97.161  1.00 43.90  ? 191  LEU C CG  1 
ATOM   5798 C CD1 . LEU E 2 179 ? -54.897 43.017  -96.705  1.00 45.37  ? 191  LEU C CD1 1 
ATOM   5799 C CD2 . LEU E 2 179 ? -56.043 41.965  -98.654  1.00 35.70  ? 191  LEU C CD2 1 
ATOM   5800 N N   . ASP E 2 180 ? -57.461 38.839  -93.969  1.00 50.49  ? 192  ASP C N   1 
ATOM   5801 C CA  . ASP E 2 180 ? -58.212 37.646  -93.603  1.00 56.33  ? 192  ASP C CA  1 
ATOM   5802 C C   . ASP E 2 180 ? -59.401 38.048  -92.740  1.00 60.29  ? 192  ASP C C   1 
ATOM   5803 O O   . ASP E 2 180 ? -59.251 38.824  -91.790  1.00 61.78  ? 192  ASP C O   1 
ATOM   5804 C CB  . ASP E 2 180 ? -57.318 36.650  -92.863  1.00 57.15  ? 192  ASP C CB  1 
ATOM   5805 C CG  . ASP E 2 180 ? -57.654 35.204  -93.192  1.00 70.02  ? 192  ASP C CG  1 
ATOM   5806 O OD1 . ASP E 2 180 ? -58.550 34.636  -92.530  1.00 71.37  ? 192  ASP C OD1 1 
ATOM   5807 O OD2 . ASP E 2 180 ? -57.030 34.635  -94.115  1.00 81.79  ? 192  ASP C OD2 1 
ATOM   5808 N N   . ASP E 2 181 ? -60.584 37.524  -93.081  1.00 62.65  ? 193  ASP C N   1 
ATOM   5809 C CA  . ASP E 2 181 ? -61.808 37.910  -92.382  1.00 62.38  ? 193  ASP C CA  1 
ATOM   5810 C C   . ASP E 2 181 ? -61.677 37.723  -90.875  1.00 66.91  ? 193  ASP C C   1 
ATOM   5811 O O   . ASP E 2 181 ? -62.104 38.582  -90.093  1.00 61.69  ? 193  ASP C O   1 
ATOM   5812 C CB  . ASP E 2 181 ? -62.997 37.103  -92.915  1.00 64.21  ? 193  ASP C CB  1 
ATOM   5813 C CG  . ASP E 2 181 ? -63.427 37.533  -94.309  1.00 62.88  ? 193  ASP C CG  1 
ATOM   5814 O OD1 . ASP E 2 181 ? -63.343 38.740  -94.621  1.00 67.31  ? 193  ASP C OD1 1 
ATOM   5815 O OD2 . ASP E 2 181 ? -63.865 36.660  -95.089  1.00 62.08  ? 193  ASP C OD2 1 
ATOM   5816 N N   . THR E 2 182 ? -61.077 36.609  -90.450  1.00 61.77  ? 194  THR C N   1 
ATOM   5817 C CA  . THR E 2 182 ? -60.931 36.347  -89.023  1.00 59.73  ? 194  THR C CA  1 
ATOM   5818 C C   . THR E 2 182 ? -59.920 37.288  -88.380  1.00 43.49  ? 194  THR C C   1 
ATOM   5819 O O   . THR E 2 182 ? -60.031 37.592  -87.186  1.00 50.02  ? 194  THR C O   1 
ATOM   5820 C CB  . THR E 2 182 ? -60.524 34.891  -88.797  1.00 59.31  ? 194  THR C CB  1 
ATOM   5821 O OG1 . THR E 2 182 ? -59.584 34.499  -89.804  1.00 63.29  ? 194  THR C OG1 1 
ATOM   5822 C CG2 . THR E 2 182 ? -61.747 33.982  -88.875  1.00 38.78  ? 194  THR C CG2 1 
ATOM   5823 N N   . GLY E 2 183 ? -58.933 37.756  -89.145  1.00 42.59  ? 195  GLY C N   1 
ATOM   5824 C CA  . GLY E 2 183 ? -57.995 38.727  -88.605  1.00 51.47  ? 195  GLY C CA  1 
ATOM   5825 C C   . GLY E 2 183 ? -58.614 40.102  -88.446  1.00 51.38  ? 195  GLY C C   1 
ATOM   5826 O O   . GLY E 2 183 ? -58.350 40.803  -87.465  1.00 45.45  ? 195  GLY C O   1 
ATOM   5827 N N   . LEU E 2 184 ? -59.447 40.506  -89.408  1.00 48.32  ? 196  LEU C N   1 
ATOM   5828 C CA  . LEU E 2 184 ? -60.141 41.784  -89.297  1.00 48.83  ? 196  LEU C CA  1 
ATOM   5829 C C   . LEU E 2 184 ? -61.115 41.783  -88.126  1.00 52.25  ? 196  LEU C C   1 
ATOM   5830 O O   . LEU E 2 184 ? -61.229 42.780  -87.403  1.00 60.36  ? 196  LEU C O   1 
ATOM   5831 C CB  . LEU E 2 184 ? -60.872 42.095  -90.603  1.00 44.28  ? 196  LEU C CB  1 
ATOM   5832 C CG  . LEU E 2 184 ? -61.561 43.455  -90.715  1.00 37.46  ? 196  LEU C CG  1 
ATOM   5833 C CD1 . LEU E 2 184 ? -60.661 44.585  -90.232  1.00 36.57  ? 196  LEU C CD1 1 
ATOM   5834 C CD2 . LEU E 2 184 ? -62.004 43.693  -92.143  1.00 40.24  ? 196  LEU C CD2 1 
ATOM   5835 N N   . ALA E 2 185 ? -61.824 40.671  -87.920  1.00 44.20  ? 197  ALA C N   1 
ATOM   5836 C CA  . ALA E 2 185 ? -62.752 40.594  -86.797  1.00 30.35  ? 197  ALA C CA  1 
ATOM   5837 C C   . ALA E 2 185 ? -62.011 40.589  -85.467  1.00 41.02  ? 197  ALA C C   1 
ATOM   5838 O O   . ALA E 2 185 ? -62.481 41.180  -84.488  1.00 54.40  ? 197  ALA C O   1 
ATOM   5839 C CB  . ALA E 2 185 ? -63.636 39.355  -86.927  1.00 29.04  ? 197  ALA C CB  1 
ATOM   5840 N N   . TYR E 2 186 ? -60.848 39.934  -85.411  1.00 44.38  ? 198  TYR C N   1 
ATOM   5841 C CA  . TYR E 2 186 ? -60.097 39.864  -84.161  1.00 46.66  ? 198  TYR C CA  1 
ATOM   5842 C C   . TYR E 2 186 ? -59.482 41.214  -83.807  1.00 47.63  ? 198  TYR C C   1 
ATOM   5843 O O   . TYR E 2 186 ? -59.493 41.618  -82.638  1.00 51.17  ? 198  TYR C O   1 
ATOM   5844 C CB  . TYR E 2 186 ? -59.017 38.784  -84.261  1.00 52.59  ? 198  TYR C CB  1 
ATOM   5845 C CG  . TYR E 2 186 ? -58.163 38.599  -83.016  1.00 56.74  ? 198  TYR C CG  1 
ATOM   5846 C CD1 . TYR E 2 186 ? -57.021 39.369  -82.810  1.00 48.95  ? 198  TYR C CD1 1 
ATOM   5847 C CD2 . TYR E 2 186 ? -58.487 37.640  -82.060  1.00 50.20  ? 198  TYR C CD2 1 
ATOM   5848 C CE1 . TYR E 2 186 ? -56.233 39.201  -81.683  1.00 49.27  ? 198  TYR C CE1 1 
ATOM   5849 C CE2 . TYR E 2 186 ? -57.702 37.463  -80.927  1.00 42.76  ? 198  TYR C CE2 1 
ATOM   5850 C CZ  . TYR E 2 186 ? -56.576 38.248  -80.745  1.00 47.69  ? 198  TYR C CZ  1 
ATOM   5851 O OH  . TYR E 2 186 ? -55.787 38.084  -79.625  1.00 34.70  ? 198  TYR C OH  1 
ATOM   5852 N N   . ILE E 2 187 ? -58.943 41.925  -84.802  1.00 44.46  ? 199  ILE C N   1 
ATOM   5853 C CA  . ILE E 2 187 ? -58.295 43.207  -84.537  1.00 44.87  ? 199  ILE C CA  1 
ATOM   5854 C C   . ILE E 2 187 ? -59.320 44.257  -84.124  1.00 45.64  ? 199  ILE C C   1 
ATOM   5855 O O   . ILE E 2 187 ? -58.995 45.206  -83.399  1.00 48.09  ? 199  ILE C O   1 
ATOM   5856 C CB  . ILE E 2 187 ? -57.476 43.648  -85.768  1.00 39.03  ? 199  ILE C CB  1 
ATOM   5857 C CG1 . ILE E 2 187 ? -56.282 42.710  -85.971  1.00 49.14  ? 199  ILE C CG1 1 
ATOM   5858 C CG2 . ILE E 2 187 ? -56.985 45.084  -85.631  1.00 26.65  ? 199  ILE C CG2 1 
ATOM   5859 C CD1 . ILE E 2 187 ? -55.285 43.190  -87.004  1.00 37.07  ? 199  ILE C CD1 1 
ATOM   5860 N N   . CYS E 2 188 ? -60.574 44.096  -84.540  1.00 45.00  ? 200  CYS C N   1 
ATOM   5861 C CA  . CYS E 2 188 ? -61.605 45.081  -84.255  1.00 53.81  ? 200  CYS C CA  1 
ATOM   5862 C C   . CYS E 2 188 ? -62.645 44.609  -83.247  1.00 58.60  ? 200  CYS C C   1 
ATOM   5863 O O   . CYS E 2 188 ? -63.616 45.334  -83.005  1.00 76.65  ? 200  CYS C O   1 
ATOM   5864 C CB  . CYS E 2 188 ? -62.308 45.493  -85.549  1.00 51.15  ? 200  CYS C CB  1 
ATOM   5865 S SG  . CYS E 2 188 ? -61.204 45.974  -86.890  1.00 62.96  ? 200  CYS C SG  1 
ATOM   5866 N N   . GLN E 2 189 ? -62.484 43.420  -82.658  1.00 52.88  ? 201  GLN C N   1 
ATOM   5867 C CA  A GLN E 2 189 ? -63.433 42.947  -81.653  0.57 47.16  ? 201  GLN C CA  1 
ATOM   5868 C CA  B GLN E 2 189 ? -63.464 42.985  -81.671  0.43 47.08  ? 201  GLN C CA  1 
ATOM   5869 C C   . GLN E 2 189 ? -63.342 43.763  -80.368  1.00 36.91  ? 201  GLN C C   1 
ATOM   5870 O O   . GLN E 2 189 ? -64.325 43.862  -79.626  1.00 33.59  ? 201  GLN C O   1 
ATOM   5871 C CB  A GLN E 2 189 ? -63.189 41.460  -81.370  0.57 40.80  ? 201  GLN C CB  1 
ATOM   5872 C CB  B GLN E 2 189 ? -63.343 41.477  -81.418  0.43 40.82  ? 201  GLN C CB  1 
ATOM   5873 C CG  A GLN E 2 189 ? -63.913 40.895  -80.151  0.57 36.23  ? 201  GLN C CG  1 
ATOM   5874 C CG  B GLN E 2 189 ? -62.196 41.058  -80.516  0.43 42.02  ? 201  GLN C CG  1 
ATOM   5875 C CD  A GLN E 2 189 ? -65.314 40.411  -80.470  0.57 27.75  ? 201  GLN C CD  1 
ATOM   5876 C CD  B GLN E 2 189 ? -62.093 39.547  -80.369  0.43 35.45  ? 201  GLN C CD  1 
ATOM   5877 O OE1 A GLN E 2 189 ? -65.577 39.918  -81.566  0.57 34.22  ? 201  GLN C OE1 1 
ATOM   5878 O OE1 B GLN E 2 189 ? -61.576 39.041  -79.371  0.43 28.55  ? 201  GLN C OE1 1 
ATOM   5879 N NE2 A GLN E 2 189 ? -66.221 40.547  -79.509  0.57 14.06  ? 201  GLN C NE2 1 
ATOM   5880 N NE2 B GLN E 2 189 ? -62.587 38.820  -81.365  0.43 33.67  ? 201  GLN C NE2 1 
ATOM   5881 N N   . THR E 2 190 ? -62.180 44.352  -80.095  1.00 34.12  ? 202  THR C N   1 
ATOM   5882 C CA  . THR E 2 190 ? -61.949 45.139  -78.893  1.00 33.82  ? 202  THR C CA  1 
ATOM   5883 C C   . THR E 2 190 ? -61.445 46.518  -79.292  1.00 48.42  ? 202  THR C C   1 
ATOM   5884 O O   . THR E 2 190 ? -60.610 46.641  -80.193  1.00 57.84  ? 202  THR C O   1 
ATOM   5885 C CB  . THR E 2 190 ? -60.939 44.440  -77.970  1.00 37.59  ? 202  THR C CB  1 
ATOM   5886 O OG1 . THR E 2 190 ? -61.614 43.435  -77.203  1.00 74.83  ? 202  THR C OG1 1 
ATOM   5887 C CG2 . THR E 2 190 ? -60.274 45.427  -77.024  1.00 50.42  ? 202  THR C CG2 1 
ATOM   5888 N N   . TYR E 2 191 ? -61.969 47.556  -78.628  1.00 54.25  ? 203  TYR C N   1 
ATOM   5889 C CA  . TYR E 2 191 ? -61.569 48.920  -78.963  1.00 58.73  ? 203  TYR C CA  1 
ATOM   5890 C C   . TYR E 2 191 ? -60.073 49.127  -78.765  1.00 68.04  ? 203  TYR C C   1 
ATOM   5891 O O   . TYR E 2 191 ? -59.438 49.862  -79.532  1.00 89.62  ? 203  TYR C O   1 
ATOM   5892 C CB  . TYR E 2 191 ? -62.359 49.934  -78.133  1.00 65.83  ? 203  TYR C CB  1 
ATOM   5893 C CG  . TYR E 2 191 ? -61.763 51.326  -78.172  1.00 78.02  ? 203  TYR C CG  1 
ATOM   5894 C CD1 . TYR E 2 191 ? -61.958 52.155  -79.271  1.00 81.15  ? 203  TYR C CD1 1 
ATOM   5895 C CD2 . TYR E 2 191 ? -60.995 51.806  -77.117  1.00 70.30  ? 203  TYR C CD2 1 
ATOM   5896 C CE1 . TYR E 2 191 ? -61.409 53.424  -79.316  1.00 74.33  ? 203  TYR C CE1 1 
ATOM   5897 C CE2 . TYR E 2 191 ? -60.441 53.073  -77.155  1.00 78.62  ? 203  TYR C CE2 1 
ATOM   5898 C CZ  . TYR E 2 191 ? -60.652 53.878  -78.256  1.00 77.98  ? 203  TYR C CZ  1 
ATOM   5899 O OH  . TYR E 2 191 ? -60.104 55.141  -78.297  1.00 85.10  ? 203  TYR C OH  1 
ATOM   5900 N N   . GLU E 2 192 ? -59.494 48.498  -77.738  1.00 56.37  ? 204  GLU C N   1 
ATOM   5901 C CA  . GLU E 2 192 ? -58.054 48.598  -77.526  1.00 63.07  ? 204  GLU C CA  1 
ATOM   5902 C C   . GLU E 2 192 ? -57.304 48.107  -78.756  1.00 67.65  ? 204  GLU C C   1 
ATOM   5903 O O   . GLU E 2 192 ? -56.401 48.785  -79.259  1.00 86.57  ? 204  GLU C O   1 
ATOM   5904 C CB  . GLU E 2 192 ? -57.655 47.805  -76.270  1.00 77.23  ? 204  GLU C CB  1 
ATOM   5905 C CG  . GLU E 2 192 ? -56.211 47.979  -75.725  1.00 98.94  ? 204  GLU C CG  1 
ATOM   5906 C CD  . GLU E 2 192 ? -55.089 47.769  -76.744  1.00 98.72  ? 204  GLU C CD  1 
ATOM   5907 O OE1 . GLU E 2 192 ? -55.145 46.797  -77.527  1.00 93.85  ? 204  GLU C OE1 1 
ATOM   5908 O OE2 . GLU E 2 192 ? -54.151 48.594  -76.766  1.00 87.91  ? 204  GLU C OE2 1 
ATOM   5909 N N   . ARG E 2 193 ? -57.670 46.924  -79.255  1.00 52.57  ? 205  ARG C N   1 
ATOM   5910 C CA  . ARG E 2 193 ? -56.943 46.331  -80.371  1.00 55.20  ? 205  ARG C CA  1 
ATOM   5911 C C   . ARG E 2 193 ? -57.003 47.219  -81.609  1.00 53.25  ? 205  ARG C C   1 
ATOM   5912 O O   . ARG E 2 193 ? -55.997 47.387  -82.306  1.00 68.79  ? 205  ARG C O   1 
ATOM   5913 C CB  . ARG E 2 193 ? -57.496 44.939  -80.662  1.00 50.81  ? 205  ARG C CB  1 
ATOM   5914 C CG  . ARG E 2 193 ? -57.018 43.886  -79.682  1.00 55.18  ? 205  ARG C CG  1 
ATOM   5915 C CD  . ARG E 2 193 ? -57.459 42.500  -80.097  1.00 39.80  ? 205  ARG C CD  1 
ATOM   5916 N NE  . ARG E 2 193 ? -57.641 41.629  -78.943  1.00 40.21  ? 205  ARG C NE  1 
ATOM   5917 C CZ  . ARG E 2 193 ? -58.430 40.563  -78.930  1.00 51.44  ? 205  ARG C CZ  1 
ATOM   5918 N NH1 . ARG E 2 193 ? -59.127 40.206  -79.996  1.00 47.68  ? 205  ARG C NH1 1 
ATOM   5919 N NH2 . ARG E 2 193 ? -58.523 39.837  -77.820  1.00 71.19  ? 205  ARG C NH2 1 
ATOM   5920 N N   . PHE E 2 194 ? -58.168 47.805  -81.894  1.00 44.47  ? 206  PHE C N   1 
ATOM   5921 C CA  . PHE E 2 194 ? -58.260 48.760  -82.994  1.00 41.06  ? 206  PHE C CA  1 
ATOM   5922 C C   . PHE E 2 194 ? -57.457 50.019  -82.691  1.00 47.54  ? 206  PHE C C   1 
ATOM   5923 O O   . PHE E 2 194 ? -56.655 50.467  -83.520  1.00 55.72  ? 206  PHE C O   1 
ATOM   5924 C CB  . PHE E 2 194 ? -59.727 49.102  -83.281  1.00 38.66  ? 206  PHE C CB  1 
ATOM   5925 C CG  . PHE E 2 194 ? -59.919 50.114  -84.388  1.00 40.59  ? 206  PHE C CG  1 
ATOM   5926 C CD1 . PHE E 2 194 ? -59.694 51.470  -84.175  1.00 48.92  ? 206  PHE C CD1 1 
ATOM   5927 C CD2 . PHE E 2 194 ? -60.313 49.705  -85.649  1.00 56.09  ? 206  PHE C CD2 1 
ATOM   5928 C CE1 . PHE E 2 194 ? -59.864 52.389  -85.195  1.00 59.25  ? 206  PHE C CE1 1 
ATOM   5929 C CE2 . PHE E 2 194 ? -60.483 50.625  -86.671  1.00 58.31  ? 206  PHE C CE2 1 
ATOM   5930 C CZ  . PHE E 2 194 ? -60.261 51.966  -86.442  1.00 59.33  ? 206  PHE C CZ  1 
ATOM   5931 N N   . SER E 2 195 ? -57.672 50.613  -81.512  1.00 51.73  ? 207  SER C N   1 
ATOM   5932 C CA  . SER E 2 195 ? -57.049 51.895  -81.194  1.00 43.28  ? 207  SER C CA  1 
ATOM   5933 C C   . SER E 2 195 ? -55.530 51.816  -81.281  1.00 49.92  ? 207  SER C C   1 
ATOM   5934 O O   . SER E 2 195 ? -54.885 52.743  -81.781  1.00 62.24  ? 207  SER C O   1 
ATOM   5935 C CB  . SER E 2 195 ? -57.482 52.364  -79.804  1.00 44.98  ? 207  SER C CB  1 
ATOM   5936 O OG  . SER E 2 195 ? -56.608 51.876  -78.801  1.00 68.61  ? 207  SER C OG  1 
ATOM   5937 N N   . HIS E 2 196 ? -54.940 50.716  -80.806  1.00 50.96  ? 208  HIS C N   1 
ATOM   5938 C CA  . HIS E 2 196 ? -53.494 50.555  -80.925  1.00 46.74  ? 208  HIS C CA  1 
ATOM   5939 C C   . HIS E 2 196 ? -53.070 50.480  -82.389  1.00 59.25  ? 208  HIS C C   1 
ATOM   5940 O O   . HIS E 2 196 ? -52.033 51.034  -82.770  1.00 63.30  ? 208  HIS C O   1 
ATOM   5941 C CB  . HIS E 2 196 ? -53.032 49.313  -80.159  1.00 50.30  ? 208  HIS C CB  1 
ATOM   5942 C CG  . HIS E 2 196 ? -51.562 49.292  -79.862  1.00 77.08  ? 208  HIS C CG  1 
ATOM   5943 N ND1 . HIS E 2 196 ? -50.678 50.203  -80.401  1.00 76.26  ? 208  HIS C ND1 1 
ATOM   5944 C CD2 . HIS E 2 196 ? -50.820 48.461  -79.092  1.00 82.10  ? 208  HIS C CD2 1 
ATOM   5945 C CE1 . HIS E 2 196 ? -49.457 49.938  -79.971  1.00 56.36  ? 208  HIS C CE1 1 
ATOM   5946 N NE2 . HIS E 2 196 ? -49.515 48.885  -79.177  1.00 70.65  ? 208  HIS C NE2 1 
ATOM   5947 N N   . VAL E 2 197 ? -53.867 49.812  -83.227  1.00 61.15  ? 209  VAL C N   1 
ATOM   5948 C CA  . VAL E 2 197 ? -53.549 49.740  -84.651  1.00 48.97  ? 209  VAL C CA  1 
ATOM   5949 C C   . VAL E 2 197 ? -53.759 51.096  -85.316  1.00 52.04  ? 209  VAL C C   1 
ATOM   5950 O O   . VAL E 2 197 ? -52.953 51.525  -86.151  1.00 64.96  ? 209  VAL C O   1 
ATOM   5951 C CB  . VAL E 2 197 ? -54.382 48.636  -85.332  1.00 40.28  ? 209  VAL C CB  1 
ATOM   5952 C CG1 . VAL E 2 197 ? -54.217 48.689  -86.849  1.00 26.69  ? 209  VAL C CG1 1 
ATOM   5953 C CG2 . VAL E 2 197 ? -53.977 47.271  -84.805  1.00 45.05  ? 209  VAL C CG2 1 
ATOM   5954 N N   . ALA E 2 198 ? -54.834 51.798  -84.950  1.00 55.50  ? 210  ALA C N   1 
ATOM   5955 C CA  . ALA E 2 198 ? -55.111 53.095  -85.559  1.00 47.38  ? 210  ALA C CA  1 
ATOM   5956 C C   . ALA E 2 198 ? -54.053 54.127  -85.184  1.00 53.19  ? 210  ALA C C   1 
ATOM   5957 O O   . ALA E 2 198 ? -53.624 54.918  -86.034  1.00 55.41  ? 210  ALA C O   1 
ATOM   5958 C CB  . ALA E 2 198 ? -56.505 53.578  -85.154  1.00 40.63  ? 210  ALA C CB  1 
ATOM   5959 N N   . MET E 2 199 ? -53.615 54.132  -83.920  1.00 50.71  ? 211  MET C N   1 
ATOM   5960 C CA  . MET E 2 199 ? -52.629 55.117  -83.478  1.00 54.75  ? 211  MET C CA  1 
ATOM   5961 C C   . MET E 2 199 ? -51.309 54.959  -84.223  1.00 56.50  ? 211  MET C C   1 
ATOM   5962 O O   . MET E 2 199 ? -50.685 55.954  -84.607  1.00 58.28  ? 211  MET C O   1 
ATOM   5963 C CB  . MET E 2 199 ? -52.409 55.009  -81.967  1.00 62.39  ? 211  MET C CB  1 
ATOM   5964 C CG  . MET E 2 199 ? -53.590 55.480  -81.127  1.00 71.77  ? 211  MET C CG  1 
ATOM   5965 S SD  . MET E 2 199 ? -53.258 56.956  -80.144  1.00 116.10 ? 211  MET C SD  1 
ATOM   5966 C CE  . MET E 2 199 ? -54.872 57.235  -79.415  1.00 85.27  ? 211  MET C CE  1 
ATOM   5967 N N   . ILE E 2 200 ? -50.865 53.718  -84.434  1.00 61.52  ? 212  ILE C N   1 
ATOM   5968 C CA  . ILE E 2 200 ? -49.640 53.489  -85.197  1.00 55.72  ? 212  ILE C CA  1 
ATOM   5969 C C   . ILE E 2 200 ? -49.831 53.923  -86.645  1.00 47.02  ? 212  ILE C C   1 
ATOM   5970 O O   . ILE E 2 200 ? -49.079 54.757  -87.161  1.00 57.23  ? 212  ILE C O   1 
ATOM   5971 C CB  . ILE E 2 200 ? -49.207 52.015  -85.102  1.00 43.38  ? 212  ILE C CB  1 
ATOM   5972 C CG1 . ILE E 2 200 ? -48.995 51.613  -83.643  1.00 45.94  ? 212  ILE C CG1 1 
ATOM   5973 C CG2 . ILE E 2 200 ? -47.936 51.780  -85.899  1.00 40.85  ? 212  ILE C CG2 1 
ATOM   5974 C CD1 . ILE E 2 200 ? -48.031 52.509  -82.901  1.00 41.65  ? 212  ILE C CD1 1 
ATOM   5975 N N   . LEU E 2 201 ? -50.856 53.378  -87.309  1.00 46.85  ? 213  LEU C N   1 
ATOM   5976 C CA  . LEU E 2 201 ? -51.107 53.690  -88.716  1.00 48.85  ? 213  LEU C CA  1 
ATOM   5977 C C   . LEU E 2 201 ? -51.188 55.193  -88.958  1.00 54.66  ? 213  LEU C C   1 
ATOM   5978 O O   . LEU E 2 201 ? -50.708 55.692  -89.983  1.00 58.19  ? 213  LEU C O   1 
ATOM   5979 C CB  . LEU E 2 201 ? -52.399 53.014  -89.178  1.00 38.25  ? 213  LEU C CB  1 
ATOM   5980 C CG  . LEU E 2 201 ? -52.345 51.528  -89.534  1.00 25.58  ? 213  LEU C CG  1 
ATOM   5981 C CD1 . LEU E 2 201 ? -53.700 51.057  -90.053  1.00 33.22  ? 213  LEU C CD1 1 
ATOM   5982 C CD2 . LEU E 2 201 ? -51.245 51.253  -90.546  1.00 26.31  ? 213  LEU C CD2 1 
ATOM   5983 N N   . GLY E 2 202 ? -51.798 55.930  -88.028  1.00 50.38  ? 214  GLY C N   1 
ATOM   5984 C CA  . GLY E 2 202 ? -51.840 57.376  -88.160  1.00 54.48  ? 214  GLY C CA  1 
ATOM   5985 C C   . GLY E 2 202 ? -50.484 58.023  -87.952  1.00 51.01  ? 214  GLY C C   1 
ATOM   5986 O O   . GLY E 2 202 ? -50.152 59.014  -88.609  1.00 48.44  ? 214  GLY C O   1 
ATOM   5987 N N   . LYS E 2 203 ? -49.680 57.472  -87.038  1.00 43.80  ? 215  LYS C N   1 
ATOM   5988 C CA  . LYS E 2 203 ? -48.364 58.044  -86.775  1.00 46.53  ? 215  LYS C CA  1 
ATOM   5989 C C   . LYS E 2 203 ? -47.428 57.862  -87.965  1.00 63.29  ? 215  LYS C C   1 
ATOM   5990 O O   . LYS E 2 203 ? -46.645 58.766  -88.285  1.00 66.14  ? 215  LYS C O   1 
ATOM   5991 C CB  . LYS E 2 203 ? -47.764 57.426  -85.513  1.00 48.65  ? 215  LYS C CB  1 
ATOM   5992 C CG  . LYS E 2 203 ? -48.354 57.967  -84.218  1.00 57.37  ? 215  LYS C CG  1 
ATOM   5993 C CD  . LYS E 2 203 ? -47.626 57.424  -82.997  1.00 59.02  ? 215  LYS C CD  1 
ATOM   5994 C CE  . LYS E 2 203 ? -46.215 57.981  -82.900  1.00 59.44  ? 215  LYS C CE  1 
ATOM   5995 N NZ  . LYS E 2 203 ? -45.625 57.757  -81.550  1.00 51.88  ? 215  LYS C NZ  1 
ATOM   5996 N N   . MET E 2 204 ? -47.486 56.703  -88.632  1.00 59.99  ? 216  MET C N   1 
ATOM   5997 C CA  . MET E 2 204 ? -46.673 56.513  -89.831  1.00 63.44  ? 216  MET C CA  1 
ATOM   5998 C C   . MET E 2 204 ? -47.069 57.484  -90.932  1.00 74.16  ? 216  MET C C   1 
ATOM   5999 O O   . MET E 2 204 ? -46.209 57.937  -91.695  1.00 88.34  ? 216  MET C O   1 
ATOM   6000 C CB  . MET E 2 204 ? -46.776 55.077  -90.347  1.00 57.87  ? 216  MET C CB  1 
ATOM   6001 C CG  . MET E 2 204 ? -47.096 54.033  -89.303  1.00 52.57  ? 216  MET C CG  1 
ATOM   6002 S SD  . MET E 2 204 ? -47.417 52.418  -90.035  1.00 59.44  ? 216  MET C SD  1 
ATOM   6003 C CE  . MET E 2 204 ? -45.781 51.992  -90.620  1.00 54.38  ? 216  MET C CE  1 
ATOM   6004 N N   . VAL E 2 205 ? -48.358 57.812  -91.034  1.00 63.54  ? 217  VAL C N   1 
ATOM   6005 C CA  . VAL E 2 205 ? -48.795 58.781  -92.034  1.00 63.71  ? 217  VAL C CA  1 
ATOM   6006 C C   . VAL E 2 205 ? -48.188 60.149  -91.741  1.00 64.54  ? 217  VAL C C   1 
ATOM   6007 O O   . VAL E 2 205 ? -47.773 60.871  -92.657  1.00 69.90  ? 217  VAL C O   1 
ATOM   6008 C CB  . VAL E 2 205 ? -50.334 58.830  -92.090  1.00 45.33  ? 217  VAL C CB  1 
ATOM   6009 C CG1 . VAL E 2 205 ? -50.805 60.107  -92.759  1.00 57.02  ? 217  VAL C CG1 1 
ATOM   6010 C CG2 . VAL E 2 205 ? -50.876 57.607  -92.819  1.00 43.57  ? 217  VAL C CG2 1 
ATOM   6011 N N   . LEU E 2 206 ? -48.111 60.519  -90.459  1.00 57.12  ? 218  LEU C N   1 
ATOM   6012 C CA  . LEU E 2 206 ? -47.440 61.759  -90.081  1.00 62.92  ? 218  LEU C CA  1 
ATOM   6013 C C   . LEU E 2 206 ? -45.979 61.743  -90.510  1.00 77.54  ? 218  LEU C C   1 
ATOM   6014 O O   . LEU E 2 206 ? -45.498 62.680  -91.158  1.00 92.37  ? 218  LEU C O   1 
ATOM   6015 C CB  . LEU E 2 206 ? -47.551 61.983  -88.571  1.00 70.10  ? 218  LEU C CB  1 
ATOM   6016 C CG  . LEU E 2 206 ? -48.327 63.211  -88.084  1.00 59.66  ? 218  LEU C CG  1 
ATOM   6017 C CD1 . LEU E 2 206 ? -48.381 63.252  -86.563  1.00 27.91  ? 218  LEU C CD1 1 
ATOM   6018 C CD2 . LEU E 2 206 ? -47.698 64.484  -88.629  1.00 59.72  ? 218  LEU C CD2 1 
ATOM   6019 N N   . GLN E 2 207 ? -45.258 60.676  -90.164  1.00 72.21  ? 219  GLN C N   1 
ATOM   6020 C CA  . GLN E 2 207 ? -43.846 60.572  -90.502  1.00 73.94  ? 219  GLN C CA  1 
ATOM   6021 C C   . GLN E 2 207 ? -43.604 60.213  -91.961  1.00 78.26  ? 219  GLN C C   1 
ATOM   6022 O O   . GLN E 2 207 ? -42.460 60.302  -92.418  1.00 93.48  ? 219  GLN C O   1 
ATOM   6023 C CB  . GLN E 2 207 ? -43.162 59.547  -89.594  1.00 73.85  ? 219  GLN C CB  1 
ATOM   6024 C CG  . GLN E 2 207 ? -41.847 60.034  -89.008  1.00 82.81  ? 219  GLN C CG  1 
ATOM   6025 C CD  . GLN E 2 207 ? -42.036 61.076  -87.917  1.00 103.84 ? 219  GLN C CD  1 
ATOM   6026 O OE1 . GLN E 2 207 ? -43.163 61.410  -87.543  1.00 87.75  ? 219  GLN C OE1 1 
ATOM   6027 N NE2 . GLN E 2 207 ? -40.927 61.599  -87.404  1.00 103.39 ? 219  GLN C NE2 1 
ATOM   6028 N N   . LEU E 2 208 ? -44.638 59.811  -92.701  1.00 71.59  ? 220  LEU C N   1 
ATOM   6029 C CA  . LEU E 2 208 ? -44.488 59.621  -94.138  1.00 75.34  ? 220  LEU C CA  1 
ATOM   6030 C C   . LEU E 2 208 ? -44.605 60.928  -94.909  1.00 82.68  ? 220  LEU C C   1 
ATOM   6031 O O   . LEU E 2 208 ? -44.261 60.965  -96.096  1.00 81.17  ? 220  LEU C O   1 
ATOM   6032 C CB  . LEU E 2 208 ? -45.516 58.611  -94.651  1.00 65.17  ? 220  LEU C CB  1 
ATOM   6033 C CG  . LEU E 2 208 ? -44.913 57.267  -95.066  1.00 61.38  ? 220  LEU C CG  1 
ATOM   6034 C CD1 . LEU E 2 208 ? -44.147 56.639  -93.910  1.00 59.95  ? 220  LEU C CD1 1 
ATOM   6035 C CD2 . LEU E 2 208 ? -45.996 56.329  -95.556  1.00 57.25  ? 220  LEU C CD2 1 
ATOM   6036 N N   . SER E 2 209 ? -45.083 61.993  -94.266  1.00 86.73  ? 221  SER C N   1 
ATOM   6037 C CA  . SER E 2 209 ? -45.000 63.334  -94.826  1.00 74.73  ? 221  SER C CA  1 
ATOM   6038 C C   . SER E 2 209 ? -43.675 64.008  -94.501  1.00 79.25  ? 221  SER C C   1 
ATOM   6039 O O   . SER E 2 209 ? -43.182 64.808  -95.305  1.00 99.24  ? 221  SER C O   1 
ATOM   6040 C CB  . SER E 2 209 ? -46.158 64.192  -94.311  1.00 76.85  ? 221  SER C CB  1 
ATOM   6041 O OG  . SER E 2 209 ? -45.801 64.855  -93.110  1.00 65.38  ? 221  SER C OG  1 
ATOM   6042 N N   . LYS E 2 210 ? -43.088 63.702  -93.340  1.00 80.10  ? 222  LYS C N   1 
ATOM   6043 C CA  . LYS E 2 210 ? -41.768 64.232  -93.010  1.00 83.46  ? 222  LYS C CA  1 
ATOM   6044 C C   . LYS E 2 210 ? -40.671 63.530  -93.802  1.00 91.82  ? 222  LYS C C   1 
ATOM   6045 O O   . LYS E 2 210 ? -39.638 64.140  -94.102  1.00 93.32  ? 222  LYS C O   1 
ATOM   6046 C CB  . LYS E 2 210 ? -41.510 64.102  -91.508  1.00 73.94  ? 222  LYS C CB  1 
ATOM   6047 C CG  . LYS E 2 210 ? -42.689 64.517  -90.640  1.00 72.23  ? 222  LYS C CG  1 
ATOM   6048 C CD  . LYS E 2 210 ? -42.295 65.579  -89.626  1.00 75.14  ? 222  LYS C CD  1 
ATOM   6049 C CE  . LYS E 2 210 ? -43.522 66.155  -88.929  1.00 86.21  ? 222  LYS C CE  1 
ATOM   6050 N NZ  . LYS E 2 210 ? -43.846 65.446  -87.659  1.00 75.14  ? 222  LYS C NZ  1 
ATOM   6051 N N   . GLU E 2 211 ? -40.870 62.255  -94.136  1.00 89.61  ? 223  GLU C N   1 
ATOM   6052 C CA  . GLU E 2 211 ? -39.980 61.511  -95.019  1.00 82.86  ? 223  GLU C CA  1 
ATOM   6053 C C   . GLU E 2 211 ? -40.809 60.499  -95.804  1.00 86.22  ? 223  GLU C C   1 
ATOM   6054 O O   . GLU E 2 211 ? -41.439 59.613  -95.213  1.00 93.55  ? 223  GLU C O   1 
ATOM   6055 C CB  . GLU E 2 211 ? -38.858 60.824  -94.232  1.00 80.95  ? 223  GLU C CB  1 
ATOM   6056 C CG  . GLU E 2 211 ? -39.321 59.951  -93.072  1.00 101.95 ? 223  GLU C CG  1 
ATOM   6057 C CD  . GLU E 2 211 ? -38.410 60.043  -91.864  1.00 109.58 ? 223  GLU C CD  1 
ATOM   6058 O OE1 . GLU E 2 211 ? -37.196 60.277  -92.046  1.00 127.79 ? 223  GLU C OE1 1 
ATOM   6059 O OE2 . GLU E 2 211 ? -38.910 59.876  -90.731  1.00 88.69  ? 223  GLU C OE2 1 
ATOM   6060 N N   . PRO E 2 212 ? -40.847 60.601  -97.132  1.00 83.85  ? 224  PRO C N   1 
ATOM   6061 C CA  . PRO E 2 212 ? -41.774 59.772  -97.908  1.00 78.25  ? 224  PRO C CA  1 
ATOM   6062 C C   . PRO E 2 212 ? -41.194 58.415  -98.274  1.00 81.76  ? 224  PRO C C   1 
ATOM   6063 O O   . PRO E 2 212 ? -39.997 58.259  -98.523  1.00 78.50  ? 224  PRO C O   1 
ATOM   6064 C CB  . PRO E 2 212 ? -42.018 60.621  -99.163  1.00 61.94  ? 224  PRO C CB  1 
ATOM   6065 C CG  . PRO E 2 212 ? -40.785 61.488  -99.298  1.00 67.25  ? 224  PRO C CG  1 
ATOM   6066 C CD  . PRO E 2 212 ? -40.022 61.464  -97.993  1.00 85.12  ? 224  PRO C CD  1 
ATOM   6067 N N   . SER E 2 213 ? -42.075 57.415  -98.295  1.00 74.87  ? 225  SER C N   1 
ATOM   6068 C CA  . SER E 2 213 ? -41.733 56.073  -98.758  1.00 64.66  ? 225  SER C CA  1 
ATOM   6069 C C   . SER E 2 213 ? -42.935 55.537  -99.520  1.00 58.41  ? 225  SER C C   1 
ATOM   6070 O O   . SER E 2 213 ? -43.995 55.309  -98.928  1.00 73.87  ? 225  SER C O   1 
ATOM   6071 C CB  . SER E 2 213 ? -41.365 55.150  -97.596  1.00 77.50  ? 225  SER C CB  1 
ATOM   6072 O OG  . SER E 2 213 ? -41.755 53.816  -97.873  1.00 78.93  ? 225  SER C OG  1 
ATOM   6073 N N   . ALA E 2 214 ? -42.772 55.343  -100.831 1.00 66.44  ? 226  ALA C N   1 
ATOM   6074 C CA  . ALA E 2 214 ? -43.897 54.932  -101.665 1.00 61.11  ? 226  ALA C CA  1 
ATOM   6075 C C   . ALA E 2 214 ? -44.385 53.535  -101.300 1.00 72.54  ? 226  ALA C C   1 
ATOM   6076 O O   . ALA E 2 214 ? -45.591 53.264  -101.350 1.00 73.77  ? 226  ALA C O   1 
ATOM   6077 C CB  . ALA E 2 214 ? -43.507 54.998  -103.141 1.00 56.15  ? 226  ALA C CB  1 
ATOM   6078 N N   . ARG E 2 215 ? -43.470 52.633  -100.936 1.00 76.50  ? 227  ARG C N   1 
ATOM   6079 C CA  . ARG E 2 215 ? -43.882 51.288  -100.546 1.00 73.73  ? 227  ARG C CA  1 
ATOM   6080 C C   . ARG E 2 215 ? -44.670 51.313  -99.243  1.00 76.37  ? 227  ARG C C   1 
ATOM   6081 O O   . ARG E 2 215 ? -45.782 50.778  -99.169  1.00 76.23  ? 227  ARG C O   1 
ATOM   6082 C CB  . ARG E 2 215 ? -42.668 50.370  -100.410 1.00 61.63  ? 227  ARG C CB  1 
ATOM   6083 C CG  . ARG E 2 215 ? -41.540 50.645  -101.378 1.00 78.00  ? 227  ARG C CG  1 
ATOM   6084 C CD  . ARG E 2 215 ? -40.204 50.569  -100.662 1.00 91.60  ? 227  ARG C CD  1 
ATOM   6085 N NE  . ARG E 2 215 ? -39.762 49.188  -100.498 1.00 75.14  ? 227  ARG C NE  1 
ATOM   6086 C CZ  . ARG E 2 215 ? -38.635 48.825  -99.900  1.00 61.46  ? 227  ARG C CZ  1 
ATOM   6087 N NH1 . ARG E 2 215 ? -37.790 49.719  -99.415  1.00 70.07  ? 227  ARG C NH1 1 
ATOM   6088 N NH2 . ARG E 2 215 ? -38.348 47.531  -99.789  1.00 59.86  ? 227  ARG C NH2 1 
ATOM   6089 N N   . LEU E 2 216 ? -44.104 51.933  -98.203  1.00 66.28  ? 228  LEU C N   1 
ATOM   6090 C CA  . LEU E 2 216 ? -44.766 51.970  -96.902  1.00 61.29  ? 228  LEU C CA  1 
ATOM   6091 C C   . LEU E 2 216 ? -46.150 52.599  -97.007  1.00 59.69  ? 228  LEU C C   1 
ATOM   6092 O O   . LEU E 2 216 ? -47.104 52.126  -96.379  1.00 66.11  ? 228  LEU C O   1 
ATOM   6093 C CB  . LEU E 2 216 ? -43.896 52.733  -95.901  1.00 46.09  ? 228  LEU C CB  1 
ATOM   6094 C CG  . LEU E 2 216 ? -44.302 52.750  -94.429  1.00 41.17  ? 228  LEU C CG  1 
ATOM   6095 C CD1 . LEU E 2 216 ? -44.881 51.407  -94.017  1.00 45.13  ? 228  LEU C CD1 1 
ATOM   6096 C CD2 . LEU E 2 216 ? -43.105 53.112  -93.563  1.00 51.77  ? 228  LEU C CD2 1 
ATOM   6097 N N   . LEU E 2 217 ? -46.281 53.655  -97.812  1.00 54.39  ? 229  LEU C N   1 
ATOM   6098 C CA  . LEU E 2 217 ? -47.584 54.281  -98.005  1.00 52.48  ? 229  LEU C CA  1 
ATOM   6099 C C   . LEU E 2 217 ? -48.555 53.330  -98.696  1.00 62.09  ? 229  LEU C C   1 
ATOM   6100 O O   . LEU E 2 217 ? -49.754 53.331  -98.395  1.00 64.16  ? 229  LEU C O   1 
ATOM   6101 C CB  . LEU E 2 217 ? -47.425 55.571  -98.810  1.00 53.30  ? 229  LEU C CB  1 
ATOM   6102 C CG  . LEU E 2 217 ? -48.651 56.462  -99.020  1.00 53.70  ? 229  LEU C CG  1 
ATOM   6103 C CD1 . LEU E 2 217 ? -49.518 56.511  -97.770  1.00 52.61  ? 229  LEU C CD1 1 
ATOM   6104 C CD2 . LEU E 2 217 ? -48.224 57.861  -99.441  1.00 70.76  ? 229  LEU C CD2 1 
ATOM   6105 N N   . LYS E 2 218 ? -48.053 52.505  -99.621  1.00 57.12  ? 230  LYS C N   1 
ATOM   6106 C CA  . LYS E 2 218 ? -48.925 51.574  -100.333 1.00 63.76  ? 230  LYS C CA  1 
ATOM   6107 C C   . LYS E 2 218 ? -49.515 50.532  -99.388  1.00 77.45  ? 230  LYS C C   1 
ATOM   6108 O O   . LYS E 2 218 ? -50.689 50.161  -99.513  1.00 72.13  ? 230  LYS C O   1 
ATOM   6109 C CB  . LYS E 2 218 ? -48.154 50.897  -101.469 1.00 65.04  ? 230  LYS C CB  1 
ATOM   6110 C CG  . LYS E 2 218 ? -48.730 49.557  -101.914 1.00 67.13  ? 230  LYS C CG  1 
ATOM   6111 C CD  . LYS E 2 218 ? -48.253 49.183  -103.305 1.00 58.35  ? 230  LYS C CD  1 
ATOM   6112 C CE  . LYS E 2 218 ? -49.388 48.621  -104.138 1.00 61.67  ? 230  LYS C CE  1 
ATOM   6113 N NZ  . LYS E 2 218 ? -48.924 48.125  -105.462 1.00 68.87  ? 230  LYS C NZ  1 
ATOM   6114 N N   . HIS E 2 219 ? -48.717 50.052  -98.430  1.00 74.06  ? 231  HIS C N   1 
ATOM   6115 C CA  . HIS E 2 219 ? -49.215 49.078  -97.466  1.00 55.09  ? 231  HIS C CA  1 
ATOM   6116 C C   . HIS E 2 219 ? -50.018 49.736  -96.349  1.00 58.54  ? 231  HIS C C   1 
ATOM   6117 O O   . HIS E 2 219 ? -50.907 49.097  -95.778  1.00 70.70  ? 231  HIS C O   1 
ATOM   6118 C CB  . HIS E 2 219 ? -48.053 48.276  -96.878  1.00 56.98  ? 231  HIS C CB  1 
ATOM   6119 C CG  . HIS E 2 219 ? -47.361 47.392  -97.870  1.00 61.06  ? 231  HIS C CG  1 
ATOM   6120 N ND1 . HIS E 2 219 ? -45.989 47.349  -98.000  1.00 56.67  ? 231  HIS C ND1 1 
ATOM   6121 C CD2 . HIS E 2 219 ? -47.852 46.517  -98.780  1.00 65.26  ? 231  HIS C CD2 1 
ATOM   6122 C CE1 . HIS E 2 219 ? -45.665 46.486  -98.947  1.00 57.60  ? 231  HIS C CE1 1 
ATOM   6123 N NE2 . HIS E 2 219 ? -46.777 45.967  -99.435  1.00 72.72  ? 231  HIS C NE2 1 
ATOM   6124 N N   . VAL E 2 220 ? -49.723 50.997  -96.022  1.00 53.68  ? 232  VAL C N   1 
ATOM   6125 C CA  . VAL E 2 220 ? -50.517 51.712  -95.026  1.00 44.27  ? 232  VAL C CA  1 
ATOM   6126 C C   . VAL E 2 220 ? -51.907 52.026  -95.574  1.00 51.39  ? 232  VAL C C   1 
ATOM   6127 O O   . VAL E 2 220 ? -52.903 51.980  -94.841  1.00 50.82  ? 232  VAL C O   1 
ATOM   6128 C CB  . VAL E 2 220 ? -49.776 52.983  -94.565  1.00 40.98  ? 232  VAL C CB  1 
ATOM   6129 C CG1 . VAL E 2 220 ? -50.715 53.939  -93.838  1.00 25.00  ? 232  VAL C CG1 1 
ATOM   6130 C CG2 . VAL E 2 220 ? -48.614 52.612  -93.656  1.00 47.95  ? 232  VAL C CG2 1 
ATOM   6131 N N   . VAL E 2 221 ? -52.003 52.326  -96.872  1.00 48.10  ? 233  VAL C N   1 
ATOM   6132 C CA  . VAL E 2 221 ? -53.302 52.639  -97.465  1.00 50.57  ? 233  VAL C CA  1 
ATOM   6133 C C   . VAL E 2 221 ? -54.177 51.392  -97.540  1.00 57.15  ? 233  VAL C C   1 
ATOM   6134 O O   . VAL E 2 221 ? -55.377 51.443  -97.239  1.00 67.94  ? 233  VAL C O   1 
ATOM   6135 C CB  . VAL E 2 221 ? -53.118 53.292  -98.848  1.00 63.63  ? 233  VAL C CB  1 
ATOM   6136 C CG1 . VAL E 2 221 ? -54.437 53.318  -99.607  1.00 65.55  ? 233  VAL C CG1 1 
ATOM   6137 C CG2 . VAL E 2 221 ? -52.577 54.704  -98.695  1.00 55.88  ? 233  VAL C CG2 1 
ATOM   6138 N N   . ARG E 2 222 ? -53.602 50.254  -97.942  1.00 49.52  ? 234  ARG C N   1 
ATOM   6139 C CA  . ARG E 2 222 ? -54.378 49.017  -97.978  1.00 49.72  ? 234  ARG C CA  1 
ATOM   6140 C C   . ARG E 2 222 ? -54.849 48.624  -96.584  1.00 63.42  ? 234  ARG C C   1 
ATOM   6141 O O   . ARG E 2 222 ? -55.956 48.095  -96.421  1.00 71.04  ? 234  ARG C O   1 
ATOM   6142 C CB  . ARG E 2 222 ? -53.559 47.890  -98.606  1.00 51.95  ? 234  ARG C CB  1 
ATOM   6143 C CG  . ARG E 2 222 ? -54.403 46.717  -99.088  1.00 42.13  ? 234  ARG C CG  1 
ATOM   6144 C CD  . ARG E 2 222 ? -55.673 47.204  -99.774  1.00 52.69  ? 234  ARG C CD  1 
ATOM   6145 N NE  . ARG E 2 222 ? -56.733 46.202  -99.835  1.00 64.03  ? 234  ARG C NE  1 
ATOM   6146 C CZ  . ARG E 2 222 ? -56.649 45.035  -100.462 1.00 79.61  ? 234  ARG C CZ  1 
ATOM   6147 N NH1 . ARG E 2 222 ? -55.557 44.675  -101.121 1.00 78.01  ? 234  ARG C NH1 1 
ATOM   6148 N NH2 . ARG E 2 222 ? -57.694 44.212  -100.443 1.00 82.61  ? 234  ARG C NH2 1 
ATOM   6149 N N   . CYS E 2 223 ? -54.017 48.872  -95.568  1.00 70.37  ? 235  CYS C N   1 
ATOM   6150 C CA  . CYS E 2 223 ? -54.427 48.633  -94.187  1.00 55.75  ? 235  CYS C CA  1 
ATOM   6151 C C   . CYS E 2 223 ? -55.646 49.477  -93.831  1.00 58.08  ? 235  CYS C C   1 
ATOM   6152 O O   . CYS E 2 223 ? -56.627 48.970  -93.274  1.00 71.78  ? 235  CYS C O   1 
ATOM   6153 C CB  . CYS E 2 223 ? -53.263 48.934  -93.237  1.00 51.56  ? 235  CYS C CB  1 
ATOM   6154 S SG  . CYS E 2 223 ? -51.971 47.654  -93.126  1.00 50.66  ? 235  CYS C SG  1 
ATOM   6155 N N   . TYR E 2 224 ? -55.604 50.773  -94.155  1.00 62.03  ? 236  TYR C N   1 
ATOM   6156 C CA  . TYR E 2 224 ? -56.755 51.640  -93.922  1.00 52.92  ? 236  TYR C CA  1 
ATOM   6157 C C   . TYR E 2 224 ? -57.950 51.226  -94.773  1.00 54.42  ? 236  TYR C C   1 
ATOM   6158 O O   . TYR E 2 224 ? -59.099 51.363  -94.337  1.00 55.33  ? 236  TYR C O   1 
ATOM   6159 C CB  . TYR E 2 224 ? -56.382 53.097  -94.201  1.00 46.61  ? 236  TYR C CB  1 
ATOM   6160 C CG  . TYR E 2 224 ? -55.746 53.797  -93.023  1.00 41.38  ? 236  TYR C CG  1 
ATOM   6161 C CD1 . TYR E 2 224 ? -56.432 53.936  -91.825  1.00 53.27  ? 236  TYR C CD1 1 
ATOM   6162 C CD2 . TYR E 2 224 ? -54.461 54.319  -93.107  1.00 36.35  ? 236  TYR C CD2 1 
ATOM   6163 C CE1 . TYR E 2 224 ? -55.858 54.572  -90.743  1.00 49.97  ? 236  TYR C CE1 1 
ATOM   6164 C CE2 . TYR E 2 224 ? -53.876 54.961  -92.026  1.00 39.26  ? 236  TYR C CE2 1 
ATOM   6165 C CZ  . TYR E 2 224 ? -54.583 55.083  -90.847  1.00 45.25  ? 236  TYR C CZ  1 
ATOM   6166 O OH  . TYR E 2 224 ? -54.023 55.715  -89.761  1.00 41.93  ? 236  TYR C OH  1 
ATOM   6167 N N   . LEU E 2 225 ? -57.702 50.725  -95.986  1.00 55.00  ? 237  LEU C N   1 
ATOM   6168 C CA  . LEU E 2 225 ? -58.786 50.198  -96.810  1.00 61.39  ? 237  LEU C CA  1 
ATOM   6169 C C   . LEU E 2 225 ? -59.426 48.979  -96.159  1.00 70.55  ? 237  LEU C C   1 
ATOM   6170 O O   . LEU E 2 225 ? -60.651 48.913  -96.005  1.00 74.20  ? 237  LEU C O   1 
ATOM   6171 C CB  . LEU E 2 225 ? -58.268 49.833  -98.203  1.00 55.56  ? 237  LEU C CB  1 
ATOM   6172 C CG  . LEU E 2 225 ? -59.239 50.015  -99.375  1.00 56.83  ? 237  LEU C CG  1 
ATOM   6173 C CD1 . LEU E 2 225 ? -58.497 49.969  -100.698 1.00 64.14  ? 237  LEU C CD1 1 
ATOM   6174 C CD2 . LEU E 2 225 ? -60.351 48.977  -99.356  1.00 67.73  ? 237  LEU C CD2 1 
ATOM   6175 N N   . ARG E 2 226 ? -58.606 47.990  -95.791  1.00 76.94  ? 238  ARG C N   1 
ATOM   6176 C CA  . ARG E 2 226 ? -59.144 46.752  -95.237  1.00 68.61  ? 238  ARG C CA  1 
ATOM   6177 C C   . ARG E 2 226 ? -59.868 47.004  -93.922  1.00 53.88  ? 238  ARG C C   1 
ATOM   6178 O O   . ARG E 2 226 ? -60.910 46.396  -93.654  1.00 55.34  ? 238  ARG C O   1 
ATOM   6179 C CB  . ARG E 2 226 ? -58.027 45.729  -95.045  1.00 57.45  ? 238  ARG C CB  1 
ATOM   6180 C CG  . ARG E 2 226 ? -58.521 44.402  -94.514  1.00 40.45  ? 238  ARG C CG  1 
ATOM   6181 C CD  . ARG E 2 226 ? -59.481 43.764  -95.498  1.00 49.56  ? 238  ARG C CD  1 
ATOM   6182 N NE  . ARG E 2 226 ? -60.010 42.501  -94.999  1.00 52.57  ? 238  ARG C NE  1 
ATOM   6183 C CZ  . ARG E 2 226 ? -61.271 42.111  -95.129  1.00 53.03  ? 238  ARG C CZ  1 
ATOM   6184 N NH1 . ARG E 2 226 ? -62.168 42.865  -95.743  1.00 61.57  ? 238  ARG C NH1 1 
ATOM   6185 N NH2 . ARG E 2 226 ? -61.639 40.934  -94.633  1.00 50.45  ? 238  ARG C NH2 1 
ATOM   6186 N N   . LEU E 2 227 ? -59.327 47.896  -93.088  1.00 51.60  ? 239  LEU C N   1 
ATOM   6187 C CA  . LEU E 2 227 ? -60.024 48.284  -91.866  1.00 39.31  ? 239  LEU C CA  1 
ATOM   6188 C C   . LEU E 2 227 ? -61.382 48.895  -92.186  1.00 60.34  ? 239  LEU C C   1 
ATOM   6189 O O   . LEU E 2 227 ? -62.370 48.629  -91.492  1.00 74.75  ? 239  LEU C O   1 
ATOM   6190 C CB  . LEU E 2 227 ? -59.171 49.268  -91.066  1.00 35.54  ? 239  LEU C CB  1 
ATOM   6191 C CG  . LEU E 2 227 ? -58.175 48.670  -90.072  1.00 41.62  ? 239  LEU C CG  1 
ATOM   6192 C CD1 . LEU E 2 227 ? -57.260 49.750  -89.509  1.00 37.00  ? 239  LEU C CD1 1 
ATOM   6193 C CD2 . LEU E 2 227 ? -58.905 47.942  -88.956  1.00 51.22  ? 239  LEU C CD2 1 
ATOM   6194 N N   . SER E 2 228 ? -61.456 49.697  -93.250  1.00 64.20  ? 240  SER C N   1 
ATOM   6195 C CA  . SER E 2 228 ? -62.705 50.338  -93.643  1.00 60.04  ? 240  SER C CA  1 
ATOM   6196 C C   . SER E 2 228 ? -63.798 49.342  -94.017  1.00 70.92  ? 240  SER C C   1 
ATOM   6197 O O   . SER E 2 228 ? -64.958 49.748  -94.152  1.00 76.32  ? 240  SER C O   1 
ATOM   6198 C CB  . SER E 2 228 ? -62.446 51.295  -94.810  1.00 59.30  ? 240  SER C CB  1 
ATOM   6199 O OG  . SER E 2 228 ? -62.464 50.611  -96.052  1.00 80.49  ? 240  SER C OG  1 
ATOM   6200 N N   . ASP E 2 229 ? -63.465 48.060  -94.187  1.00 69.44  ? 241  ASP C N   1 
ATOM   6201 C CA  . ASP E 2 229 ? -64.465 47.042  -94.489  1.00 67.19  ? 241  ASP C CA  1 
ATOM   6202 C C   . ASP E 2 229 ? -65.310 46.663  -93.279  1.00 68.03  ? 241  ASP C C   1 
ATOM   6203 O O   . ASP E 2 229 ? -66.338 45.997  -93.448  1.00 60.30  ? 241  ASP C O   1 
ATOM   6204 C CB  . ASP E 2 229 ? -63.790 45.786  -95.051  1.00 67.63  ? 241  ASP C CB  1 
ATOM   6205 C CG  . ASP E 2 229 ? -63.229 45.995  -96.447  1.00 75.54  ? 241  ASP C CG  1 
ATOM   6206 O OD1 . ASP E 2 229 ? -62.150 46.612  -96.572  1.00 69.40  ? 241  ASP C OD1 1 
ATOM   6207 O OD2 . ASP E 2 229 ? -63.867 45.540  -97.421  1.00 75.96  ? 241  ASP C OD2 1 
ATOM   6208 N N   . ASN E 2 230 ? -64.904 47.066  -92.068  1.00 67.48  ? 242  ASN C N   1 
ATOM   6209 C CA  . ASN E 2 230 ? -65.629 46.769  -90.839  1.00 71.44  ? 242  ASN C CA  1 
ATOM   6210 C C   . ASN E 2 230 ? -66.462 47.970  -90.424  1.00 84.19  ? 242  ASN C C   1 
ATOM   6211 O O   . ASN E 2 230 ? -65.930 49.089  -90.367  1.00 83.58  ? 242  ASN C O   1 
ATOM   6212 C CB  . ASN E 2 230 ? -64.656 46.406  -89.721  1.00 57.97  ? 242  ASN C CB  1 
ATOM   6213 C CG  . ASN E 2 230 ? -65.307 45.591  -88.627  1.00 66.05  ? 242  ASN C CG  1 
ATOM   6214 O OD1 . ASN E 2 230 ? -66.361 44.990  -88.826  1.00 105.39 ? 242  ASN C OD1 1 
ATOM   6215 N ND2 . ASN E 2 230 ? -64.688 45.576  -87.459  1.00 39.24  ? 242  ASN C ND2 1 
ATOM   6216 N N   . PRO E 2 231 ? -67.757 47.786  -90.139  1.00 83.77  ? 243  PRO C N   1 
ATOM   6217 C CA  . PRO E 2 231 ? -68.581 48.940  -89.731  1.00 77.16  ? 243  PRO C CA  1 
ATOM   6218 C C   . PRO E 2 231 ? -68.043 49.668  -88.511  1.00 71.62  ? 243  PRO C C   1 
ATOM   6219 O O   . PRO E 2 231 ? -67.906 50.898  -88.541  1.00 81.42  ? 243  PRO C O   1 
ATOM   6220 C CB  . PRO E 2 231 ? -69.949 48.300  -89.466  1.00 81.17  ? 243  PRO C CB  1 
ATOM   6221 C CG  . PRO E 2 231 ? -69.973 47.102  -90.350  1.00 75.88  ? 243  PRO C CG  1 
ATOM   6222 C CD  . PRO E 2 231 ? -68.568 46.573  -90.344  1.00 70.04  ? 243  PRO C CD  1 
ATOM   6223 N N   . ARG E 2 232 ? -67.737 48.941  -87.430  1.00 65.91  ? 244  ARG C N   1 
ATOM   6224 C CA  . ARG E 2 232 ? -67.171 49.587  -86.249  1.00 65.81  ? 244  ARG C CA  1 
ATOM   6225 C C   . ARG E 2 232 ? -65.864 50.291  -86.572  1.00 66.09  ? 244  ARG C C   1 
ATOM   6226 O O   . ARG E 2 232 ? -65.559 51.336  -85.986  1.00 67.53  ? 244  ARG C O   1 
ATOM   6227 C CB  . ARG E 2 232 ? -66.949 48.569  -85.131  1.00 68.11  ? 244  ARG C CB  1 
ATOM   6228 C CG  . ARG E 2 232 ? -68.214 48.171  -84.403  1.00 71.34  ? 244  ARG C CG  1 
ATOM   6229 C CD  . ARG E 2 232 ? -67.892 47.608  -83.023  1.00 68.27  ? 244  ARG C CD  1 
ATOM   6230 N NE  . ARG E 2 232 ? -68.988 47.749  -82.068  1.00 82.32  ? 244  ARG C NE  1 
ATOM   6231 C CZ  . ARG E 2 232 ? -69.524 48.898  -81.674  1.00 89.37  ? 244  ARG C CZ  1 
ATOM   6232 N NH1 . ARG E 2 232 ? -69.055 50.065  -82.091  1.00 106.15 ? 244  ARG C NH1 1 
ATOM   6233 N NH2 . ARG E 2 232 ? -70.551 48.878  -80.828  1.00 85.76  ? 244  ARG C NH2 1 
ATOM   6234 N N   . ALA E 2 233 ? -65.086 49.736  -87.501  1.00 69.67  ? 245  ALA C N   1 
ATOM   6235 C CA  . ALA E 2 233 ? -63.842 50.363  -87.923  1.00 59.78  ? 245  ALA C CA  1 
ATOM   6236 C C   . ALA E 2 233 ? -64.087 51.504  -88.901  1.00 69.22  ? 245  ALA C C   1 
ATOM   6237 O O   . ALA E 2 233 ? -63.309 52.464  -88.934  1.00 69.20  ? 245  ALA C O   1 
ATOM   6238 C CB  . ALA E 2 233 ? -62.926 49.314  -88.548  1.00 57.97  ? 245  ALA C CB  1 
ATOM   6239 N N   . ARG E 2 234 ? -65.154 51.412  -89.700  1.00 75.25  ? 246  ARG C N   1 
ATOM   6240 C CA  . ARG E 2 234 ? -65.518 52.507  -90.593  1.00 74.18  ? 246  ARG C CA  1 
ATOM   6241 C C   . ARG E 2 234 ? -65.824 53.777  -89.810  1.00 84.18  ? 246  ARG C C   1 
ATOM   6242 O O   . ARG E 2 234 ? -65.372 54.868  -90.178  1.00 87.10  ? 246  ARG C O   1 
ATOM   6243 C CB  . ARG E 2 234 ? -66.722 52.105  -91.445  1.00 78.06  ? 246  ARG C CB  1 
ATOM   6244 C CG  . ARG E 2 234 ? -66.574 52.393  -92.925  1.00 78.62  ? 246  ARG C CG  1 
ATOM   6245 C CD  . ARG E 2 234 ? -67.920 52.657  -93.573  1.00 85.71  ? 246  ARG C CD  1 
ATOM   6246 N NE  . ARG E 2 234 ? -68.860 51.572  -93.322  1.00 92.16  ? 246  ARG C NE  1 
ATOM   6247 C CZ  . ARG E 2 234 ? -68.774 50.364  -93.861  1.00 86.61  ? 246  ARG C CZ  1 
ATOM   6248 N NH1 . ARG E 2 234 ? -67.813 50.055  -94.717  1.00 75.98  ? 246  ARG C NH1 1 
ATOM   6249 N NH2 . ARG E 2 234 ? -69.676 49.443  -93.536  1.00 91.46  ? 246  ARG C NH2 1 
ATOM   6250 N N   . GLU E 2 235 ? -66.585 53.651  -88.720  1.00 84.05  ? 247  GLU C N   1 
ATOM   6251 C CA  . GLU E 2 235 ? -67.007 54.821  -87.956  1.00 75.71  ? 247  GLU C CA  1 
ATOM   6252 C C   . GLU E 2 235 ? -65.821 55.520  -87.304  1.00 76.73  ? 247  GLU C C   1 
ATOM   6253 O O   . GLU E 2 235 ? -65.698 56.749  -87.371  1.00 85.41  ? 247  GLU C O   1 
ATOM   6254 C CB  . GLU E 2 235 ? -68.033 54.406  -86.903  1.00 88.60  ? 247  GLU C CB  1 
ATOM   6255 C CG  . GLU E 2 235 ? -68.144 55.360  -85.729  1.00 121.03 ? 247  GLU C CG  1 
ATOM   6256 C CD  . GLU E 2 235 ? -68.436 54.639  -84.428  1.00 141.00 ? 247  GLU C CD  1 
ATOM   6257 O OE1 . GLU E 2 235 ? -68.294 53.398  -84.395  1.00 131.17 ? 247  GLU C OE1 1 
ATOM   6258 O OE2 . GLU E 2 235 ? -68.801 55.310  -83.439  1.00 145.80 ? 247  GLU C OE2 1 
ATOM   6259 N N   . ALA E 2 236 ? -64.938 54.753  -86.660  1.00 77.94  ? 248  ALA C N   1 
ATOM   6260 C CA  . ALA E 2 236 ? -63.784 55.353  -85.998  1.00 73.78  ? 248  ALA C CA  1 
ATOM   6261 C C   . ALA E 2 236 ? -62.860 56.026  -87.003  1.00 73.65  ? 248  ALA C C   1 
ATOM   6262 O O   . ALA E 2 236 ? -62.319 57.105  -86.735  1.00 74.74  ? 248  ALA C O   1 
ATOM   6263 C CB  . ALA E 2 236 ? -63.027 54.293  -85.198  1.00 63.22  ? 248  ALA C CB  1 
ATOM   6264 N N   . LEU E 2 237 ? -62.680 55.411  -88.173  1.00 75.63  ? 249  LEU C N   1 
ATOM   6265 C CA  . LEU E 2 237 ? -61.760 55.957  -89.165  1.00 74.82  ? 249  LEU C CA  1 
ATOM   6266 C C   . LEU E 2 237 ? -62.268 57.265  -89.761  1.00 88.21  ? 249  LEU C C   1 
ATOM   6267 O O   . LEU E 2 237 ? -61.462 58.124  -90.133  1.00 85.66  ? 249  LEU C O   1 
ATOM   6268 C CB  . LEU E 2 237 ? -61.520 54.934  -90.274  1.00 66.27  ? 249  LEU C CB  1 
ATOM   6269 C CG  . LEU E 2 237 ? -60.359 53.962  -90.060  1.00 62.36  ? 249  LEU C CG  1 
ATOM   6270 C CD1 . LEU E 2 237 ? -59.963 53.306  -91.376  1.00 52.27  ? 249  LEU C CD1 1 
ATOM   6271 C CD2 . LEU E 2 237 ? -59.172 54.670  -89.418  1.00 45.56  ? 249  LEU C CD2 1 
ATOM   6272 N N   . ARG E 2 238 ? -63.589 57.439  -89.862  1.00 94.54  ? 250  ARG C N   1 
ATOM   6273 C CA  . ARG E 2 238 ? -64.115 58.640  -90.505  1.00 87.83  ? 250  ARG C CA  1 
ATOM   6274 C C   . ARG E 2 238 ? -63.889 59.884  -89.652  1.00 78.60  ? 250  ARG C C   1 
ATOM   6275 O O   . ARG E 2 238 ? -63.721 60.982  -90.196  1.00 91.45  ? 250  ARG C O   1 
ATOM   6276 C CB  . ARG E 2 238 ? -65.603 58.465  -90.830  1.00 77.27  ? 250  ARG C CB  1 
ATOM   6277 C CG  . ARG E 2 238 ? -66.571 58.869  -89.721  1.00 81.52  ? 250  ARG C CG  1 
ATOM   6278 C CD  . ARG E 2 238 ? -67.791 57.955  -89.664  1.00 90.80  ? 250  ARG C CD  1 
ATOM   6279 N NE  . ARG E 2 238 ? -68.331 57.663  -90.989  1.00 98.16  ? 250  ARG C NE  1 
ATOM   6280 C CZ  . ARG E 2 238 ? -68.814 56.484  -91.363  1.00 101.39 ? 250  ARG C CZ  1 
ATOM   6281 N NH1 . ARG E 2 238 ? -68.858 55.457  -90.530  1.00 91.37  ? 250  ARG C NH1 1 
ATOM   6282 N NH2 . ARG E 2 238 ? -69.270 56.333  -92.604  1.00 86.37  ? 250  ARG C NH2 1 
ATOM   6283 N N   . GLN E 2 239 ? -63.863 59.740  -88.327  1.00 60.50  ? 251  GLN C N   1 
ATOM   6284 C CA  . GLN E 2 239 ? -63.657 60.876  -87.440  1.00 72.32  ? 251  GLN C CA  1 
ATOM   6285 C C   . GLN E 2 239 ? -62.196 61.091  -87.069  1.00 83.23  ? 251  GLN C C   1 
ATOM   6286 O O   . GLN E 2 239 ? -61.865 62.140  -86.506  1.00 85.91  ? 251  GLN C O   1 
ATOM   6287 C CB  . GLN E 2 239 ? -64.486 60.713  -86.161  1.00 83.35  ? 251  GLN C CB  1 
ATOM   6288 C CG  . GLN E 2 239 ? -65.843 60.062  -86.373  1.00 93.81  ? 251  GLN C CG  1 
ATOM   6289 C CD  . GLN E 2 239 ? -66.995 61.008  -86.087  1.00 106.18 ? 251  GLN C CD  1 
ATOM   6290 O OE1 . GLN E 2 239 ? -66.838 62.002  -85.376  1.00 106.75 ? 251  GLN C OE1 1 
ATOM   6291 N NE2 . GLN E 2 239 ? -68.163 60.703  -86.642  1.00 88.93  ? 251  GLN C NE2 1 
ATOM   6292 N N   . CYS E 2 240 ? -61.315 60.131  -87.367  1.00 86.36  ? 252  CYS C N   1 
ATOM   6293 C CA  . CYS E 2 240 ? -59.909 60.292  -87.019  1.00 94.44  ? 252  CYS C CA  1 
ATOM   6294 C C   . CYS E 2 240 ? -58.976 59.785  -88.115  1.00 90.53  ? 252  CYS C C   1 
ATOM   6295 O O   . CYS E 2 240 ? -57.836 59.406  -87.816  1.00 103.56 ? 252  CYS C O   1 
ATOM   6296 C CB  . CYS E 2 240 ? -59.588 59.583  -85.697  1.00 103.02 ? 252  CYS C CB  1 
ATOM   6297 S SG  . CYS E 2 240 ? -59.500 57.776  -85.792  1.00 130.28 ? 252  CYS C SG  1 
ATOM   6298 N N   . LEU E 2 241 ? -59.425 59.756  -89.366  1.00 78.48  ? 253  LEU C N   1 
ATOM   6299 C CA  . LEU E 2 241 ? -58.509 59.484  -90.462  1.00 69.11  ? 253  LEU C CA  1 
ATOM   6300 C C   . LEU E 2 241 ? -57.376 60.502  -90.412  1.00 81.92  ? 253  LEU C C   1 
ATOM   6301 O O   . LEU E 2 241 ? -57.642 61.700  -90.238  1.00 97.63  ? 253  LEU C O   1 
ATOM   6302 C CB  . LEU E 2 241 ? -59.218 59.568  -91.813  1.00 65.85  ? 253  LEU C CB  1 
ATOM   6303 C CG  . LEU E 2 241 ? -58.736 58.667  -92.962  1.00 64.41  ? 253  LEU C CG  1 
ATOM   6304 C CD1 . LEU E 2 241 ? -58.163 57.324  -92.503  1.00 62.06  ? 253  LEU C CD1 1 
ATOM   6305 C CD2 . LEU E 2 241 ? -59.817 58.485  -94.021  1.00 58.89  ? 253  LEU C CD2 1 
ATOM   6306 N N   . PRO E 2 242 ? -56.117 60.080  -90.523  1.00 79.08  ? 254  PRO C N   1 
ATOM   6307 C CA  . PRO E 2 242 ? -55.024 61.059  -90.572  1.00 89.61  ? 254  PRO C CA  1 
ATOM   6308 C C   . PRO E 2 242 ? -55.259 62.072  -91.682  1.00 96.02  ? 254  PRO C C   1 
ATOM   6309 O O   . PRO E 2 242 ? -55.460 61.714  -92.846  1.00 84.26  ? 254  PRO C O   1 
ATOM   6310 C CB  . PRO E 2 242 ? -53.779 60.206  -90.825  1.00 78.53  ? 254  PRO C CB  1 
ATOM   6311 C CG  . PRO E 2 242 ? -54.161 58.809  -90.567  1.00 81.54  ? 254  PRO C CG  1 
ATOM   6312 C CD  . PRO E 2 242 ? -55.642 58.685  -90.546  1.00 74.40  ? 254  PRO C CD  1 
ATOM   6313 N N   . ASP E 2 243 ? -55.245 63.353  -91.302  1.00 98.36  ? 255  ASP C N   1 
ATOM   6314 C CA  . ASP E 2 243 ? -55.668 64.406  -92.218  1.00 88.99  ? 255  ASP C CA  1 
ATOM   6315 C C   . ASP E 2 243 ? -54.813 64.451  -93.477  1.00 83.14  ? 255  ASP C C   1 
ATOM   6316 O O   . ASP E 2 243 ? -55.301 64.876  -94.528  1.00 86.88  ? 255  ASP C O   1 
ATOM   6317 C CB  . ASP E 2 243 ? -55.648 65.763  -91.509  1.00 92.15  ? 255  ASP C CB  1 
ATOM   6318 C CG  . ASP E 2 243 ? -56.387 65.740  -90.181  1.00 109.00 ? 255  ASP C CG  1 
ATOM   6319 O OD1 . ASP E 2 243 ? -56.936 66.790  -89.783  1.00 107.28 ? 255  ASP C OD1 1 
ATOM   6320 O OD2 . ASP E 2 243 ? -56.418 64.671  -89.533  1.00 110.39 ? 255  ASP C OD2 1 
ATOM   6321 N N   . GLN E 2 244 ? -53.555 63.993  -93.398  1.00 76.62  ? 256  GLN C N   1 
ATOM   6322 C CA  . GLN E 2 244 ? -52.657 64.034  -94.552  1.00 78.05  ? 256  GLN C CA  1 
ATOM   6323 C C   . GLN E 2 244 ? -53.256 63.336  -95.765  1.00 82.46  ? 256  GLN C C   1 
ATOM   6324 O O   . GLN E 2 244 ? -52.999 63.742  -96.905  1.00 92.56  ? 256  GLN C O   1 
ATOM   6325 C CB  . GLN E 2 244 ? -51.306 63.417  -94.197  1.00 80.17  ? 256  GLN C CB  1 
ATOM   6326 C CG  . GLN E 2 244 ? -50.430 64.307  -93.333  1.00 69.96  ? 256  GLN C CG  1 
ATOM   6327 C CD  . GLN E 2 244 ? -50.847 64.297  -91.876  1.00 75.88  ? 256  GLN C CD  1 
ATOM   6328 O OE1 . GLN E 2 244 ? -51.950 64.724  -91.530  1.00 81.43  ? 256  GLN C OE1 1 
ATOM   6329 N NE2 . GLN E 2 244 ? -49.966 63.809  -91.013  1.00 79.22  ? 256  GLN C NE2 1 
ATOM   6330 N N   . LEU E 2 245 ? -54.037 62.282  -95.544  1.00 72.02  ? 257  LEU C N   1 
ATOM   6331 C CA  . LEU E 2 245 ? -54.928 61.763  -96.572  1.00 74.74  ? 257  LEU C CA  1 
ATOM   6332 C C   . LEU E 2 245 ? -56.140 62.684  -96.647  1.00 83.05  ? 257  LEU C C   1 
ATOM   6333 O O   . LEU E 2 245 ? -56.855 62.846  -95.651  1.00 73.91  ? 257  LEU C O   1 
ATOM   6334 C CB  . LEU E 2 245 ? -55.342 60.330  -96.243  1.00 84.79  ? 257  LEU C CB  1 
ATOM   6335 C CG  . LEU E 2 245 ? -54.197 59.376  -95.888  1.00 80.22  ? 257  LEU C CG  1 
ATOM   6336 C CD1 . LEU E 2 245 ? -54.260 58.978  -94.421  1.00 60.70  ? 257  LEU C CD1 1 
ATOM   6337 C CD2 . LEU E 2 245 ? -54.203 58.141  -96.781  1.00 74.59  ? 257  LEU C CD2 1 
ATOM   6338 N N   . LYS E 2 246 ? -56.352 63.297  -97.815  1.00 103.58 ? 258  LYS C N   1 
ATOM   6339 C CA  . LYS E 2 246 ? -57.301 64.381  -98.128  1.00 95.95  ? 258  LYS C CA  1 
ATOM   6340 C C   . LYS E 2 246 ? -56.669 65.749  -97.861  1.00 96.84  ? 258  LYS C C   1 
ATOM   6341 O O   . LYS E 2 246 ? -57.347 66.766  -98.043  1.00 100.67 ? 258  LYS C O   1 
ATOM   6342 C CB  . LYS E 2 246 ? -58.638 64.282  -97.366  1.00 76.54  ? 258  LYS C CB  1 
ATOM   6343 C CG  . LYS E 2 246 ? -59.845 64.924  -98.044  1.00 74.19  ? 258  LYS C CG  1 
ATOM   6344 C CD  . LYS E 2 246 ? -60.181 64.276  -99.374  1.00 78.58  ? 258  LYS C CD  1 
ATOM   6345 C CE  . LYS E 2 246 ? -61.639 64.528  -99.731  1.00 63.12  ? 258  LYS C CE  1 
ATOM   6346 N NZ  . LYS E 2 246 ? -61.883 64.487  -101.198 1.00 48.77  ? 258  LYS C NZ  1 
ATOM   6347 N N   . ASP E 2 247 ? -55.403 65.809  -97.444  1.00 104.92 ? 259  ASP C N   1 
ATOM   6348 C CA  . ASP E 2 247 ? -54.687 67.062  -97.229  1.00 94.97  ? 259  ASP C CA  1 
ATOM   6349 C C   . ASP E 2 247 ? -53.825 67.455  -98.417  1.00 104.88 ? 259  ASP C C   1 
ATOM   6350 O O   . ASP E 2 247 ? -53.010 68.374  -98.292  1.00 118.94 ? 259  ASP C O   1 
ATOM   6351 C CB  . ASP E 2 247 ? -53.798 66.968  -95.988  1.00 90.95  ? 259  ASP C CB  1 
ATOM   6352 C CG  . ASP E 2 247 ? -53.795 68.238  -95.161  1.00 101.60 ? 259  ASP C CG  1 
ATOM   6353 O OD1 . ASP E 2 247 ? -54.190 69.299  -95.685  1.00 124.35 ? 259  ASP C OD1 1 
ATOM   6354 O OD2 . ASP E 2 247 ? -53.382 68.171  -93.983  1.00 94.46  ? 259  ASP C OD2 1 
ATOM   6355 N N   . THR E 2 248 ? -53.969 66.761  -99.550  1.00 100.36 ? 260  THR C N   1 
ATOM   6356 C CA  . THR E 2 248 ? -53.120 66.918  -100.741 1.00 110.28 ? 260  THR C CA  1 
ATOM   6357 C C   . THR E 2 248 ? -51.626 66.950  -100.393 1.00 110.21 ? 260  THR C C   1 
ATOM   6358 O O   . THR E 2 248 ? -50.803 67.481  -101.146 1.00 113.93 ? 260  THR C O   1 
ATOM   6359 C CB  . THR E 2 248 ? -53.541 68.141  -101.580 1.00 104.69 ? 260  THR C CB  1 
ATOM   6360 O OG1 . THR E 2 248 ? -53.074 67.979  -102.925 1.00 99.91  ? 260  THR C OG1 1 
ATOM   6361 C CG2 . THR E 2 248 ? -53.020 69.475  -101.024 1.00 102.71 ? 260  THR C CG2 1 
ATOM   6362 N N   . THR E 2 249 ? -51.253 66.331  -99.268  1.00 90.70  ? 261  THR C N   1 
ATOM   6363 C CA  . THR E 2 249 ? -49.844 66.213  -98.910  1.00 72.10  ? 261  THR C CA  1 
ATOM   6364 C C   . THR E 2 249 ? -49.153 65.100  -99.687  1.00 77.66  ? 261  THR C C   1 
ATOM   6365 O O   . THR E 2 249 ? -47.937 65.162  -99.902  1.00 75.00  ? 261  THR C O   1 
ATOM   6366 C CB  . THR E 2 249 ? -49.691 65.961  -97.407  1.00 74.81  ? 261  THR C CB  1 
ATOM   6367 O OG1 . THR E 2 249 ? -50.721 66.654  -96.693  1.00 83.34  ? 261  THR C OG1 1 
ATOM   6368 C CG2 . THR E 2 249 ? -48.332 66.443  -96.914  1.00 78.24  ? 261  THR C CG2 1 
ATOM   6369 N N   . PHE E 2 250 ? -49.902 64.084  -100.114 1.00 82.70  ? 262  PHE C N   1 
ATOM   6370 C CA  . PHE E 2 250 ? -49.347 62.932  -100.812 1.00 92.45  ? 262  PHE C CA  1 
ATOM   6371 C C   . PHE E 2 250 ? -49.691 62.923  -102.296 1.00 99.07  ? 262  PHE C C   1 
ATOM   6372 O O   . PHE E 2 250 ? -49.527 61.889  -102.952 1.00 94.25  ? 262  PHE C O   1 
ATOM   6373 C CB  . PHE E 2 250 ? -49.836 61.635  -100.160 1.00 83.52  ? 262  PHE C CB  1 
ATOM   6374 C CG  . PHE E 2 250 ? -49.289 61.404  -98.780  1.00 72.79  ? 262  PHE C CG  1 
ATOM   6375 C CD1 . PHE E 2 250 ? -47.952 61.631  -98.499  1.00 70.59  ? 262  PHE C CD1 1 
ATOM   6376 C CD2 . PHE E 2 250 ? -50.119 60.967  -97.760  1.00 68.03  ? 262  PHE C CD2 1 
ATOM   6377 C CE1 . PHE E 2 250 ? -47.451 61.422  -97.227  1.00 75.98  ? 262  PHE C CE1 1 
ATOM   6378 C CE2 . PHE E 2 250 ? -49.625 60.756  -96.486  1.00 71.04  ? 262  PHE C CE2 1 
ATOM   6379 C CZ  . PHE E 2 250 ? -48.289 60.984  -96.219  1.00 68.65  ? 262  PHE C CZ  1 
ATOM   6380 N N   . ALA E 2 251 ? -50.159 64.049  -102.842 1.00 98.29  ? 263  ALA C N   1 
ATOM   6381 C CA  . ALA E 2 251 ? -50.615 64.070  -104.230 1.00 100.98 ? 263  ALA C CA  1 
ATOM   6382 C C   . ALA E 2 251 ? -49.480 63.758  -105.198 1.00 108.78 ? 263  ALA C C   1 
ATOM   6383 O O   . ALA E 2 251 ? -49.694 63.107  -106.228 1.00 94.69  ? 263  ALA C O   1 
ATOM   6384 C CB  . ALA E 2 251 ? -51.240 65.426  -104.553 1.00 81.23  ? 263  ALA C CB  1 
ATOM   6385 N N   . GLN E 2 252 ? -48.265 64.205  -104.879 1.00 111.91 ? 264  GLN C N   1 
ATOM   6386 C CA  . GLN E 2 252 ? -47.151 64.036  -105.805 1.00 111.83 ? 264  GLN C CA  1 
ATOM   6387 C C   . GLN E 2 252 ? -46.681 62.584  -105.868 1.00 117.47 ? 264  GLN C C   1 
ATOM   6388 O O   . GLN E 2 252 ? -46.300 62.104  -106.941 1.00 103.64 ? 264  GLN C O   1 
ATOM   6389 C CB  . GLN E 2 252 ? -46.016 64.996  -105.428 1.00 96.64  ? 264  GLN C CB  1 
ATOM   6390 C CG  . GLN E 2 252 ? -45.750 65.137  -103.929 1.00 101.78 ? 264  GLN C CG  1 
ATOM   6391 C CD  . GLN E 2 252 ? -44.941 63.996  -103.334 1.00 115.29 ? 264  GLN C CD  1 
ATOM   6392 O OE1 . GLN E 2 252 ? -44.441 63.126  -104.050 1.00 128.23 ? 264  GLN C OE1 1 
ATOM   6393 N NE2 . GLN E 2 252 ? -44.814 63.992  -102.011 1.00 93.97  ? 264  GLN C NE2 1 
ATOM   6394 N N   . VAL E 2 253 ? -46.724 61.862  -104.743 1.00 119.66 ? 265  VAL C N   1 
ATOM   6395 C CA  . VAL E 2 253 ? -46.264 60.472  -104.735 1.00 109.55 ? 265  VAL C CA  1 
ATOM   6396 C C   . VAL E 2 253 ? -47.131 59.605  -105.636 1.00 109.29 ? 265  VAL C C   1 
ATOM   6397 O O   . VAL E 2 253 ? -46.653 58.620  -106.212 1.00 108.38 ? 265  VAL C O   1 
ATOM   6398 C CB  . VAL E 2 253 ? -46.246 59.892  -103.302 1.00 104.15 ? 265  VAL C CB  1 
ATOM   6399 C CG1 . VAL E 2 253 ? -45.292 58.699  -103.224 1.00 96.65  ? 265  VAL C CG1 1 
ATOM   6400 C CG2 . VAL E 2 253 ? -45.897 60.942  -102.266 1.00 93.35  ? 265  VAL C CG2 1 
ATOM   6401 N N   . LEU E 2 254 ? -48.409 59.957  -105.779 1.00 107.58 ? 266  LEU C N   1 
ATOM   6402 C CA  . LEU E 2 254 ? -49.390 59.023  -106.321 1.00 119.07 ? 266  LEU C CA  1 
ATOM   6403 C C   . LEU E 2 254 ? -49.162 58.724  -107.797 1.00 113.13 ? 266  LEU C C   1 
ATOM   6404 O O   . LEU E 2 254 ? -49.410 57.595  -108.232 1.00 115.26 ? 266  LEU C O   1 
ATOM   6405 C CB  . LEU E 2 254 ? -50.800 59.565  -106.099 1.00 125.84 ? 266  LEU C CB  1 
ATOM   6406 C CG  . LEU E 2 254 ? -51.586 58.902  -104.967 1.00 112.98 ? 266  LEU C CG  1 
ATOM   6407 C CD1 . LEU E 2 254 ? -50.850 59.045  -103.641 1.00 100.04 ? 266  LEU C CD1 1 
ATOM   6408 C CD2 . LEU E 2 254 ? -52.988 59.482  -104.869 1.00 99.70  ? 266  LEU C CD2 1 
ATOM   6409 N N   . LYS E 2 255 ? -48.667 59.700  -108.567 1.00 105.64 ? 267  LYS C N   1 
ATOM   6410 C CA  . LYS E 2 255 ? -48.637 59.577  -110.026 1.00 104.58 ? 267  LYS C CA  1 
ATOM   6411 C C   . LYS E 2 255 ? -47.995 58.272  -110.494 1.00 108.80 ? 267  LYS C C   1 
ATOM   6412 O O   . LYS E 2 255 ? -48.454 57.662  -111.467 1.00 95.23  ? 267  LYS C O   1 
ATOM   6413 C CB  . LYS E 2 255 ? -47.914 60.782  -110.639 1.00 97.99  ? 267  LYS C CB  1 
ATOM   6414 C CG  . LYS E 2 255 ? -46.394 60.751  -110.510 1.00 93.01  ? 267  LYS C CG  1 
ATOM   6415 C CD  . LYS E 2 255 ? -45.727 60.450  -111.847 1.00 93.61  ? 267  LYS C CD  1 
ATOM   6416 C CE  . LYS E 2 255 ? -44.302 60.981  -111.895 1.00 91.01  ? 267  LYS C CE  1 
ATOM   6417 N NZ  . LYS E 2 255 ? -43.500 60.340  -112.977 1.00 89.59  ? 267  LYS C NZ  1 
ATOM   6418 N N   . ASP E 2 256 ? -46.945 57.817  -109.804 1.00 112.45 ? 268  ASP C N   1 
ATOM   6419 C CA  . ASP E 2 256 ? -46.234 56.622  -110.249 1.00 117.60 ? 268  ASP C CA  1 
ATOM   6420 C C   . ASP E 2 256 ? -47.046 55.360  -109.982 1.00 111.86 ? 268  ASP C C   1 
ATOM   6421 O O   . ASP E 2 256 ? -47.074 54.445  -110.814 1.00 91.08  ? 268  ASP C O   1 
ATOM   6422 C CB  . ASP E 2 256 ? -44.868 56.542  -109.564 1.00 122.37 ? 268  ASP C CB  1 
ATOM   6423 C CG  . ASP E 2 256 ? -43.750 56.167  -110.524 1.00 130.83 ? 268  ASP C CG  1 
ATOM   6424 O OD1 . ASP E 2 256 ? -43.774 55.036  -111.057 1.00 121.45 ? 268  ASP C OD1 1 
ATOM   6425 O OD2 . ASP E 2 256 ? -42.844 56.999  -110.741 1.00 119.29 ? 268  ASP C OD2 1 
ATOM   6426 N N   . ASP E 2 257 ? -47.716 55.294  -108.833 1.00 119.77 ? 269  ASP C N   1 
ATOM   6427 C CA  . ASP E 2 257 ? -48.476 54.116  -108.419 1.00 110.78 ? 269  ASP C CA  1 
ATOM   6428 C C   . ASP E 2 257 ? -49.957 54.378  -108.670 1.00 103.74 ? 269  ASP C C   1 
ATOM   6429 O O   . ASP E 2 257 ? -50.612 55.084  -107.900 1.00 100.88 ? 269  ASP C O   1 
ATOM   6430 C CB  . ASP E 2 257 ? -48.212 53.796  -106.950 1.00 90.00  ? 269  ASP C CB  1 
ATOM   6431 C CG  . ASP E 2 257 ? -47.981 52.315  -106.701 1.00 98.35  ? 269  ASP C CG  1 
ATOM   6432 O OD1 . ASP E 2 257 ? -48.894 51.509  -106.983 1.00 96.91  ? 269  ASP C OD1 1 
ATOM   6433 O OD2 . ASP E 2 257 ? -46.888 51.956  -106.215 1.00 107.43 ? 269  ASP C OD2 1 
ATOM   6434 N N   . THR E 2 258 ? -50.488 53.803  -109.752 1.00 102.85 ? 270  THR C N   1 
ATOM   6435 C CA  . THR E 2 258 ? -51.916 53.920  -110.019 1.00 93.35  ? 270  THR C CA  1 
ATOM   6436 C C   . THR E 2 258 ? -52.749 53.064  -109.073 1.00 90.43  ? 270  THR C C   1 
ATOM   6437 O O   . THR E 2 258 ? -53.929 53.364  -108.864 1.00 98.25  ? 270  THR C O   1 
ATOM   6438 C CB  . THR E 2 258 ? -52.222 53.539  -111.468 1.00 88.33  ? 270  THR C CB  1 
ATOM   6439 O OG1 . THR E 2 258 ? -51.651 52.257  -111.757 1.00 107.03 ? 270  THR C OG1 1 
ATOM   6440 C CG2 . THR E 2 258 ? -51.648 54.578  -112.423 1.00 74.40  ? 270  THR C CG2 1 
ATOM   6441 N N   . THR E 2 259 ? -52.161 52.014  -108.496 1.00 84.55  ? 271  THR C N   1 
ATOM   6442 C CA  . THR E 2 259 ? -52.910 51.165  -107.576 1.00 89.59  ? 271  THR C CA  1 
ATOM   6443 C C   . THR E 2 259 ? -53.150 51.869  -106.245 1.00 90.95  ? 271  THR C C   1 
ATOM   6444 O O   . THR E 2 259 ? -54.204 51.688  -105.624 1.00 97.65  ? 271  THR C O   1 
ATOM   6445 C CB  . THR E 2 259 ? -52.173 49.841  -107.362 1.00 92.43  ? 271  THR C CB  1 
ATOM   6446 O OG1 . THR E 2 259 ? -51.112 50.026  -106.416 1.00 100.47 ? 271  THR C OG1 1 
ATOM   6447 C CG2 . THR E 2 259 ? -51.592 49.333  -108.675 1.00 78.62  ? 271  THR C CG2 1 
ATOM   6448 N N   . THR E 2 260 ? -52.188 52.679  -105.793 1.00 90.23  ? 272  THR C N   1 
ATOM   6449 C CA  . THR E 2 260 ? -52.345 53.376  -104.520 1.00 86.64  ? 272  THR C CA  1 
ATOM   6450 C C   . THR E 2 260 ? -53.451 54.424  -104.592 1.00 94.50  ? 272  THR C C   1 
ATOM   6451 O O   . THR E 2 260 ? -54.175 54.634  -103.612 1.00 89.30  ? 272  THR C O   1 
ATOM   6452 C CB  . THR E 2 260 ? -51.015 54.011  -104.102 1.00 82.51  ? 272  THR C CB  1 
ATOM   6453 O OG1 . THR E 2 260 ? -50.005 52.997  -104.030 1.00 81.15  ? 272  THR C OG1 1 
ATOM   6454 C CG2 . THR E 2 260 ? -51.138 54.689  -102.740 1.00 55.16  ? 272  THR C CG2 1 
ATOM   6455 N N   . LYS E 2 261 ? -53.604 55.088  -105.743 1.00 95.21  ? 273  LYS C N   1 
ATOM   6456 C CA  . LYS E 2 261 ? -54.721 56.014  -105.905 1.00 90.30  ? 273  LYS C CA  1 
ATOM   6457 C C   . LYS E 2 261 ? -56.049 55.272  -105.858 1.00 84.84  ? 273  LYS C C   1 
ATOM   6458 O O   . LYS E 2 261 ? -56.999 55.728  -105.212 1.00 77.26  ? 273  LYS C O   1 
ATOM   6459 C CB  . LYS E 2 261 ? -54.600 56.790  -107.217 1.00 93.18  ? 273  LYS C CB  1 
ATOM   6460 C CG  . LYS E 2 261 ? -53.298 56.610  -107.969 1.00 84.29  ? 273  LYS C CG  1 
ATOM   6461 C CD  . LYS E 2 261 ? -53.119 57.710  -109.006 1.00 95.48  ? 273  LYS C CD  1 
ATOM   6462 C CE  . LYS E 2 261 ? -51.915 57.451  -109.893 1.00 86.35  ? 273  LYS C CE  1 
ATOM   6463 N NZ  . LYS E 2 261 ? -51.840 58.370  -111.060 1.00 85.46  ? 273  LYS C NZ  1 
ATOM   6464 N N   . ARG E 2 262 ? -56.134 54.127  -106.543 1.00 77.63  ? 274  ARG C N   1 
ATOM   6465 C CA  . ARG E 2 262 ? -57.347 53.316  -106.499 1.00 76.18  ? 274  ARG C CA  1 
ATOM   6466 C C   . ARG E 2 262 ? -57.661 52.868  -105.077 1.00 97.09  ? 274  ARG C C   1 
ATOM   6467 O O   . ARG E 2 262 ? -58.826 52.871  -104.660 1.00 109.06 ? 274  ARG C O   1 
ATOM   6468 C CB  . ARG E 2 262 ? -57.194 52.105  -107.418 1.00 68.23  ? 274  ARG C CB  1 
ATOM   6469 C CG  . ARG E 2 262 ? -58.178 50.977  -107.148 1.00 68.27  ? 274  ARG C CG  1 
ATOM   6470 C CD  . ARG E 2 262 ? -58.213 49.934  -108.263 1.00 84.22  ? 274  ARG C CD  1 
ATOM   6471 N NE  . ARG E 2 262 ? -57.094 48.996  -108.217 1.00 97.40  ? 274  ARG C NE  1 
ATOM   6472 C CZ  . ARG E 2 262 ? -55.886 49.224  -108.721 1.00 91.95  ? 274  ARG C CZ  1 
ATOM   6473 N NH1 . ARG E 2 262 ? -55.608 50.331  -109.394 1.00 85.06  ? 274  ARG C NH1 1 
ATOM   6474 N NH2 . ARG E 2 262 ? -54.937 48.303  -108.572 1.00 82.32  ? 274  ARG C NH2 1 
ATOM   6475 N N   . TRP E 2 263 ? -56.634 52.483  -104.317 1.00 89.64  ? 275  TRP C N   1 
ATOM   6476 C CA  . TRP E 2 263 ? -56.858 52.055  -102.941 1.00 73.72  ? 275  TRP C CA  1 
ATOM   6477 C C   . TRP E 2 263 ? -57.268 53.226  -102.055 1.00 78.51  ? 275  TRP C C   1 
ATOM   6478 O O   . TRP E 2 263 ? -58.157 53.088  -101.206 1.00 74.90  ? 275  TRP C O   1 
ATOM   6479 C CB  . TRP E 2 263 ? -55.607 51.366  -102.395 1.00 59.55  ? 275  TRP C CB  1 
ATOM   6480 C CG  . TRP E 2 263 ? -55.381 50.005  -102.982 1.00 57.93  ? 275  TRP C CG  1 
ATOM   6481 C CD1 . TRP E 2 263 ? -56.215 49.332  -103.827 1.00 53.12  ? 275  TRP C CD1 1 
ATOM   6482 C CD2 . TRP E 2 263 ? -54.252 49.146  -102.765 1.00 68.31  ? 275  TRP C CD2 1 
ATOM   6483 N NE1 . TRP E 2 263 ? -55.675 48.111  -104.153 1.00 68.88  ? 275  TRP C NE1 1 
ATOM   6484 C CE2 . TRP E 2 263 ? -54.471 47.972  -103.514 1.00 62.09  ? 275  TRP C CE2 1 
ATOM   6485 C CE3 . TRP E 2 263 ? -53.077 49.257  -102.012 1.00 66.11  ? 275  TRP C CE3 1 
ATOM   6486 C CZ2 . TRP E 2 263 ? -53.560 46.916  -103.532 1.00 57.14  ? 275  TRP C CZ2 1 
ATOM   6487 C CZ3 . TRP E 2 263 ? -52.174 48.207  -102.031 1.00 64.19  ? 275  TRP C CZ3 1 
ATOM   6488 C CH2 . TRP E 2 263 ? -52.421 47.053  -102.785 1.00 71.37  ? 275  TRP C CH2 1 
ATOM   6489 N N   . LEU E 2 264 ? -56.640 54.390  -102.243 1.00 77.82  ? 276  LEU C N   1 
ATOM   6490 C CA  . LEU E 2 264 ? -57.017 55.568  -101.465 1.00 75.58  ? 276  LEU C CA  1 
ATOM   6491 C C   . LEU E 2 264 ? -58.373 56.106  -101.910 1.00 85.12  ? 276  LEU C C   1 
ATOM   6492 O O   . LEU E 2 264 ? -59.148 56.610  -101.088 1.00 68.50  ? 276  LEU C O   1 
ATOM   6493 C CB  . LEU E 2 264 ? -55.933 56.642  -101.600 1.00 55.94  ? 276  LEU C CB  1 
ATOM   6494 C CG  . LEU E 2 264 ? -56.081 58.062  -101.038 1.00 61.16  ? 276  LEU C CG  1 
ATOM   6495 C CD1 . LEU E 2 264 ? -56.843 58.117  -99.721  1.00 43.20  ? 276  LEU C CD1 1 
ATOM   6496 C CD2 . LEU E 2 264 ? -54.705 58.690  -100.877 1.00 69.38  ? 276  LEU C CD2 1 
ATOM   6497 N N   . ALA E 2 265 ? -58.679 56.001  -103.207 1.00 92.72  ? 277  ALA C N   1 
ATOM   6498 C CA  . ALA E 2 265 ? -59.966 56.473  -103.711 1.00 87.07  ? 277  ALA C CA  1 
ATOM   6499 C C   . ALA E 2 265 ? -61.121 55.770  -103.012 1.00 88.07  ? 277  ALA C C   1 
ATOM   6500 O O   . ALA E 2 265 ? -62.042 56.419  -102.501 1.00 77.06  ? 277  ALA C O   1 
ATOM   6501 C CB  . ALA E 2 265 ? -60.055 56.263  -105.224 1.00 82.03  ? 277  ALA C CB  1 
ATOM   6502 N N   . GLN E 2 266 ? -61.087 54.436  -102.973 1.00 85.00  ? 278  GLN C N   1 
ATOM   6503 C CA  . GLN E 2 266 ? -62.166 53.696  -102.333 1.00 77.50  ? 278  GLN C CA  1 
ATOM   6504 C C   . GLN E 2 266 ? -62.174 53.869  -100.821 1.00 79.10  ? 278  GLN C C   1 
ATOM   6505 O O   . GLN E 2 266 ? -63.224 53.680  -100.199 1.00 91.35  ? 278  GLN C O   1 
ATOM   6506 C CB  . GLN E 2 266 ? -62.081 52.208  -102.687 1.00 67.40  ? 278  GLN C CB  1 
ATOM   6507 C CG  . GLN E 2 266 ? -63.335 51.357  -102.374 1.00 74.91  ? 278  GLN C CG  1 
ATOM   6508 C CD  . GLN E 2 266 ? -64.659 51.868  -102.965 1.00 86.79  ? 278  GLN C CD  1 
ATOM   6509 O OE1 . GLN E 2 266 ? -64.821 53.042  -103.291 1.00 85.10  ? 278  GLN C OE1 1 
ATOM   6510 N NE2 . GLN E 2 266 ? -65.623 50.961  -103.083 1.00 94.95  ? 278  GLN C NE2 1 
ATOM   6511 N N   . LEU E 2 267 ? -61.039 54.226  -100.217 1.00 78.23  ? 279  LEU C N   1 
ATOM   6512 C CA  . LEU E 2 267 ? -61.011 54.433  -98.772  1.00 77.89  ? 279  LEU C CA  1 
ATOM   6513 C C   . LEU E 2 267 ? -61.865 55.631  -98.376  1.00 90.26  ? 279  LEU C C   1 
ATOM   6514 O O   . LEU E 2 267 ? -62.755 55.517  -97.525  1.00 97.24  ? 279  LEU C O   1 
ATOM   6515 C CB  . LEU E 2 267 ? -59.572 54.615  -98.289  1.00 70.83  ? 279  LEU C CB  1 
ATOM   6516 C CG  . LEU E 2 267 ? -59.390 55.226  -96.895  1.00 62.92  ? 279  LEU C CG  1 
ATOM   6517 C CD1 . LEU E 2 267 ? -59.986 54.329  -95.817  1.00 75.78  ? 279  LEU C CD1 1 
ATOM   6518 C CD2 . LEU E 2 267 ? -57.924 55.505  -96.609  1.00 57.40  ? 279  LEU C CD2 1 
ATOM   6519 N N   . VAL E 2 268 ? -61.613 56.791  -98.990  1.00 82.86  ? 280  VAL C N   1 
ATOM   6520 C CA  . VAL E 2 268 ? -62.392 57.980  -98.656  1.00 73.44  ? 280  VAL C CA  1 
ATOM   6521 C C   . VAL E 2 268 ? -63.843 57.815  -99.091  1.00 83.50  ? 280  VAL C C   1 
ATOM   6522 O O   . VAL E 2 268 ? -64.755 58.350  -98.448  1.00 82.28  ? 280  VAL C O   1 
ATOM   6523 C CB  . VAL E 2 268 ? -61.752 59.232  -99.281  1.00 67.91  ? 280  VAL C CB  1 
ATOM   6524 C CG1 . VAL E 2 268 ? -62.308 60.495  -98.636  1.00 68.92  ? 280  VAL C CG1 1 
ATOM   6525 C CG2 . VAL E 2 268 ? -60.241 59.176  -99.138  1.00 67.07  ? 280  VAL C CG2 1 
ATOM   6526 N N   . LYS E 2 269 ? -64.087 57.071  -100.174 1.00 84.15  ? 281  LYS C N   1 
ATOM   6527 C CA  . LYS E 2 269 ? -65.463 56.828  -100.595 1.00 91.99  ? 281  LYS C CA  1 
ATOM   6528 C C   . LYS E 2 269 ? -66.153 55.816  -99.688  1.00 89.90  ? 281  LYS C C   1 
ATOM   6529 O O   . LYS E 2 269 ? -67.374 55.883  -99.505  1.00 97.32  ? 281  LYS C O   1 
ATOM   6530 C CB  . LYS E 2 269 ? -65.500 56.350  -102.049 1.00 87.88  ? 281  LYS C CB  1 
ATOM   6531 C CG  . LYS E 2 269 ? -66.901 56.317  -102.656 1.00 90.34  ? 281  LYS C CG  1 
ATOM   6532 C CD  . LYS E 2 269 ? -67.210 54.961  -103.274 1.00 89.54  ? 281  LYS C CD  1 
ATOM   6533 C CE  . LYS E 2 269 ? -68.588 54.917  -103.920 1.00 82.29  ? 281  LYS C CE  1 
ATOM   6534 N NZ  . LYS E 2 269 ? -68.766 55.959  -104.970 1.00 72.44  ? 281  LYS C NZ  1 
ATOM   6535 N N   . ASN E 2 270 ? -65.396 54.876  -99.113  1.00 82.52  ? 282  ASN C N   1 
ATOM   6536 C CA  . ASN E 2 270 ? -65.993 53.918  -98.187  1.00 83.94  ? 282  ASN C CA  1 
ATOM   6537 C C   . ASN E 2 270 ? -66.468 54.610  -96.916  1.00 91.85  ? 282  ASN C C   1 
ATOM   6538 O O   . ASN E 2 270 ? -67.555 54.310  -96.408  1.00 96.37  ? 282  ASN C O   1 
ATOM   6539 C CB  . ASN E 2 270 ? -64.996 52.807  -97.853  1.00 67.63  ? 282  ASN C CB  1 
ATOM   6540 C CG  . ASN E 2 270 ? -65.222 51.553  -98.679  1.00 88.38  ? 282  ASN C CG  1 
ATOM   6541 O OD1 . ASN E 2 270 ? -66.331 51.298  -99.152  1.00 101.73 ? 282  ASN C OD1 1 
ATOM   6542 N ND2 . ASN E 2 270 ? -64.169 50.761  -98.856  1.00 74.38  ? 282  ASN C ND2 1 
ATOM   6543 N N   . LEU E 2 271 ? -65.671 55.543  -96.389  1.00 81.95  ? 283  LEU C N   1 
ATOM   6544 C CA  . LEU E 2 271 ? -66.059 56.328  -95.223  1.00 75.86  ? 283  LEU C CA  1 
ATOM   6545 C C   . LEU E 2 271 ? -66.824 57.588  -95.599  1.00 79.76  ? 283  LEU C C   1 
ATOM   6546 O O   . LEU E 2 271 ? -66.685 58.618  -94.925  1.00 80.70  ? 283  LEU C O   1 
ATOM   6547 C CB  . LEU E 2 271 ? -64.832 56.692  -94.386  1.00 91.67  ? 283  LEU C CB  1 
ATOM   6548 C CG  . LEU E 2 271 ? -63.613 55.771  -94.374  1.00 77.94  ? 283  LEU C CG  1 
ATOM   6549 C CD1 . LEU E 2 271 ? -62.533 56.391  -93.522  1.00 67.16  ? 283  LEU C CD1 1 
ATOM   6550 C CD2 . LEU E 2 271 ? -63.957 54.395  -93.851  1.00 99.59  ? 283  LEU C CD2 1 
ATOM   6551 N N   . GLN E 2 272 ? -67.617 57.538  -96.667  1.00 99.39  ? 284  GLN C N   1 
ATOM   6552 C CA  . GLN E 2 272 ? -68.439 58.676  -97.044  1.00 111.55 ? 284  GLN C CA  1 
ATOM   6553 C C   . GLN E 2 272 ? -69.406 59.026  -95.918  1.00 113.26 ? 284  GLN C C   1 
ATOM   6554 O O   . GLN E 2 272 ? -69.702 58.212  -95.038  1.00 132.58 ? 284  GLN C O   1 
ATOM   6555 C CB  . GLN E 2 272 ? -69.217 58.376  -98.325  1.00 107.01 ? 284  GLN C CB  1 
ATOM   6556 C CG  . GLN E 2 272 ? -68.647 59.028  -99.573  1.00 108.04 ? 284  GLN C CG  1 
ATOM   6557 C CD  . GLN E 2 272 ? -69.148 58.374  -100.847 1.00 121.69 ? 284  GLN C CD  1 
ATOM   6558 O OE1 . GLN E 2 272 ? -69.610 57.232  -100.832 1.00 120.35 ? 284  GLN C OE1 1 
ATOM   6559 N NE2 . GLN E 2 272 ? -69.062 59.097  -101.958 1.00 123.54 ? 284  GLN C NE2 1 
ATOM   6560 N N   . GLU E 2 273 ? -69.895 60.260  -95.951  1.00 98.58  ? 285  GLU C N   1 
ATOM   6561 C CA  . GLU E 2 273 ? -70.852 60.720  -94.955  1.00 119.07 ? 285  GLU C CA  1 
ATOM   6562 C C   . GLU E 2 273 ? -72.115 59.860  -94.990  1.00 128.07 ? 285  GLU C C   1 
ATOM   6563 O O   . GLU E 2 273 ? -72.593 59.475  -96.058  1.00 128.22 ? 285  GLU C O   1 
ATOM   6564 C CB  . GLU E 2 273 ? -71.199 62.192  -95.186  1.00 118.42 ? 285  GLU C CB  1 
ATOM   6565 C CG  . GLU E 2 273 ? -70.124 63.162  -94.721  1.00 102.10 ? 285  GLU C CG  1 
ATOM   6566 C CD  . GLU E 2 273 ? -70.198 63.438  -93.233  1.00 107.03 ? 285  GLU C CD  1 
ATOM   6567 O OE1 . GLU E 2 273 ? -69.698 62.605  -92.447  1.00 116.96 ? 285  GLU C OE1 1 
ATOM   6568 O OE2 . GLU E 2 273 ? -70.760 64.485  -92.848  1.00 98.94  ? 285  GLU C OE2 1 
ATOM   6569 O OXT . GLU E 2 273 ? -72.682 59.518  -93.952  1.00 106.76 ? 285  GLU C OXT 1 
ATOM   6570 N N   . PRO F 3 9   ? -20.662 38.449  -73.808  1.00 92.95  ? 1353 PRO D N   1 
ATOM   6571 C CA  . PRO F 3 9   ? -20.710 38.784  -72.381  1.00 114.67 ? 1353 PRO D CA  1 
ATOM   6572 C C   . PRO F 3 9   ? -19.993 37.763  -71.497  1.00 120.40 ? 1353 PRO D C   1 
ATOM   6573 O O   . PRO F 3 9   ? -19.103 37.050  -71.959  1.00 107.09 ? 1353 PRO D O   1 
ATOM   6574 C CB  . PRO F 3 9   ? -22.217 38.808  -72.069  1.00 109.52 ? 1353 PRO D CB  1 
ATOM   6575 C CG  . PRO F 3 9   ? -22.926 38.447  -73.363  1.00 78.99  ? 1353 PRO D CG  1 
ATOM   6576 C CD  . PRO F 3 9   ? -21.954 38.692  -74.465  1.00 86.26  ? 1353 PRO D CD  1 
ATOM   6577 N N   . GLN F 3 10  ? -20.397 37.699  -70.231  1.00 124.22 ? 1354 GLN D N   1 
ATOM   6578 C CA  . GLN F 3 10  ? -19.721 36.889  -69.226  1.00 110.86 ? 1354 GLN D CA  1 
ATOM   6579 C C   . GLN F 3 10  ? -20.685 36.662  -68.070  1.00 122.09 ? 1354 GLN D C   1 
ATOM   6580 O O   . GLN F 3 10  ? -21.599 37.468  -67.854  1.00 128.79 ? 1354 GLN D O   1 
ATOM   6581 C CB  . GLN F 3 10  ? -18.432 37.573  -68.733  1.00 113.94 ? 1354 GLN D CB  1 
ATOM   6582 C CG  . GLN F 3 10  ? -18.650 38.808  -67.856  1.00 113.21 ? 1354 GLN D CG  1 
ATOM   6583 C CD  . GLN F 3 10  ? -19.446 39.898  -68.553  1.00 123.36 ? 1354 GLN D CD  1 
ATOM   6584 O OE1 . GLN F 3 10  ? -19.074 40.366  -69.630  1.00 128.20 ? 1354 GLN D OE1 1 
ATOM   6585 N NE2 . GLN F 3 10  ? -20.556 40.297  -67.944  1.00 119.77 ? 1354 GLN D NE2 1 
ATOM   6586 N N   . PRO F 3 11  ? -20.518 35.570  -67.316  1.00 121.02 ? 1355 PRO D N   1 
ATOM   6587 C CA  . PRO F 3 11  ? -21.419 35.313  -66.188  1.00 101.72 ? 1355 PRO D CA  1 
ATOM   6588 C C   . PRO F 3 11  ? -20.830 35.817  -64.881  1.00 109.30 ? 1355 PRO D C   1 
ATOM   6589 O O   . PRO F 3 11  ? -19.875 36.600  -64.891  1.00 128.37 ? 1355 PRO D O   1 
ATOM   6590 C CB  . PRO F 3 11  ? -21.554 33.784  -66.197  1.00 88.38  ? 1355 PRO D CB  1 
ATOM   6591 C CG  . PRO F 3 11  ? -20.373 33.275  -67.064  1.00 103.07 ? 1355 PRO D CG  1 
ATOM   6592 C CD  . PRO F 3 11  ? -19.556 34.471  -67.474  1.00 116.03 ? 1355 PRO D CD  1 
ATOM   6593 N N   . GLN F 3 12  ? -21.385 35.378  -63.753  1.00 105.25 ? 1356 GLN D N   1 
ATOM   6594 C CA  . GLN F 3 12  ? -20.847 35.754  -62.451  1.00 101.83 ? 1356 GLN D CA  1 
ATOM   6595 C C   . GLN F 3 12  ? -21.210 34.716  -61.399  1.00 101.69 ? 1356 GLN D C   1 
ATOM   6596 O O   . GLN F 3 12  ? -20.457 34.500  -60.444  1.00 109.90 ? 1356 GLN D O   1 
ATOM   6597 C CB  . GLN F 3 12  ? -21.355 37.137  -62.026  1.00 101.64 ? 1356 GLN D CB  1 
ATOM   6598 C CG  . GLN F 3 12  ? -20.380 38.275  -62.313  1.00 107.42 ? 1356 GLN D CG  1 
ATOM   6599 C CD  . GLN F 3 12  ? -20.745 39.569  -61.606  1.00 120.28 ? 1356 GLN D CD  1 
ATOM   6600 O OE1 . GLN F 3 12  ? -21.845 39.711  -61.070  1.00 121.47 ? 1356 GLN D OE1 1 
ATOM   6601 N NE2 . GLN F 3 12  ? -19.818 40.524  -61.604  1.00 120.14 ? 1356 GLN D NE2 1 
ATOM   6602 N N   . TYR F 3 13  ? -22.360 34.068  -61.564  1.00 91.85  ? 1357 TYR D N   1 
ATOM   6603 C CA  . TYR F 3 13  ? -22.865 33.106  -60.594  1.00 77.87  ? 1357 TYR D CA  1 
ATOM   6604 C C   . TYR F 3 13  ? -23.305 31.852  -61.331  1.00 75.31  ? 1357 TYR D C   1 
ATOM   6605 O O   . TYR F 3 13  ? -24.136 31.925  -62.242  1.00 81.48  ? 1357 TYR D O   1 
ATOM   6606 C CB  . TYR F 3 13  ? -24.025 33.701  -59.789  1.00 82.97  ? 1357 TYR D CB  1 
ATOM   6607 C CG  . TYR F 3 13  ? -23.862 35.174  -59.480  1.00 95.02  ? 1357 TYR D CG  1 
ATOM   6608 C CD1 . TYR F 3 13  ? -22.870 35.618  -58.613  1.00 97.21  ? 1357 TYR D CD1 1 
ATOM   6609 C CD2 . TYR F 3 13  ? -24.689 36.122  -60.069  1.00 85.33  ? 1357 TYR D CD2 1 
ATOM   6610 C CE1 . TYR F 3 13  ? -22.714 36.965  -58.332  1.00 90.00  ? 1357 TYR D CE1 1 
ATOM   6611 C CE2 . TYR F 3 13  ? -24.538 37.469  -59.797  1.00 84.75  ? 1357 TYR D CE2 1 
ATOM   6612 C CZ  . TYR F 3 13  ? -23.551 37.885  -58.926  1.00 98.69  ? 1357 TYR D CZ  1 
ATOM   6613 O OH  . TYR F 3 13  ? -23.397 39.226  -58.650  1.00 106.93 ? 1357 TYR D OH  1 
ATOM   6614 N N   . SER F 3 14  ? -22.743 30.710  -60.942  1.00 70.96  ? 1358 SER D N   1 
ATOM   6615 C CA  . SER F 3 14  ? -23.166 29.433  -61.494  1.00 68.42  ? 1358 SER D CA  1 
ATOM   6616 C C   . SER F 3 14  ? -24.578 29.101  -61.013  1.00 81.46  ? 1358 SER D C   1 
ATOM   6617 O O   . SER F 3 14  ? -25.196 29.841  -60.242  1.00 89.85  ? 1358 SER D O   1 
ATOM   6618 C CB  . SER F 3 14  ? -22.181 28.335  -61.102  1.00 70.98  ? 1358 SER D CB  1 
ATOM   6619 O OG  . SER F 3 14  ? -22.823 27.072  -61.049  1.00 90.70  ? 1358 SER D OG  1 
ATOM   6620 N N   . TYR F 3 15  ? -25.096 27.961  -61.477  1.00 81.11  ? 1359 TYR D N   1 
ATOM   6621 C CA  . TYR F 3 15  ? -26.455 27.567  -61.119  1.00 75.34  ? 1359 TYR D CA  1 
ATOM   6622 C C   . TYR F 3 15  ? -26.604 27.406  -59.608  1.00 84.36  ? 1359 TYR D C   1 
ATOM   6623 O O   . TYR F 3 15  ? -27.477 28.026  -58.989  1.00 78.73  ? 1359 TYR D O   1 
ATOM   6624 C CB  . TYR F 3 15  ? -26.834 26.274  -61.845  1.00 60.92  ? 1359 TYR D CB  1 
ATOM   6625 C CG  . TYR F 3 15  ? -28.323 25.998  -61.872  1.00 70.43  ? 1359 TYR D CG  1 
ATOM   6626 C CD1 . TYR F 3 15  ? -29.230 26.936  -61.397  1.00 79.11  ? 1359 TYR D CD1 1 
ATOM   6627 C CD2 . TYR F 3 15  ? -28.821 24.792  -62.350  1.00 76.03  ? 1359 TYR D CD2 1 
ATOM   6628 C CE1 . TYR F 3 15  ? -30.584 26.689  -61.409  1.00 67.16  ? 1359 TYR D CE1 1 
ATOM   6629 C CE2 . TYR F 3 15  ? -30.182 24.536  -62.362  1.00 69.92  ? 1359 TYR D CE2 1 
ATOM   6630 C CZ  . TYR F 3 15  ? -31.057 25.491  -61.888  1.00 72.07  ? 1359 TYR D CZ  1 
ATOM   6631 O OH  . TYR F 3 15  ? -32.411 25.260  -61.887  1.00 68.73  ? 1359 TYR D OH  1 
ATOM   6632 N N   . HIS F 3 16  ? -25.747 26.587  -58.993  1.00 88.90  ? 1360 HIS D N   1 
ATOM   6633 C CA  . HIS F 3 16  ? -25.853 26.316  -57.563  1.00 85.99  ? 1360 HIS D CA  1 
ATOM   6634 C C   . HIS F 3 16  ? -25.433 27.494  -56.693  1.00 74.39  ? 1360 HIS D C   1 
ATOM   6635 O O   . HIS F 3 16  ? -25.575 27.413  -55.468  1.00 75.20  ? 1360 HIS D O   1 
ATOM   6636 C CB  . HIS F 3 16  ? -25.009 25.093  -57.196  1.00 81.00  ? 1360 HIS D CB  1 
ATOM   6637 C CG  . HIS F 3 16  ? -25.661 23.786  -57.523  1.00 101.50 ? 1360 HIS D CG  1 
ATOM   6638 N ND1 . HIS F 3 16  ? -26.729 23.682  -58.388  1.00 109.45 ? 1360 HIS D ND1 1 
ATOM   6639 C CD2 . HIS F 3 16  ? -25.395 22.527  -57.101  1.00 107.19 ? 1360 HIS D CD2 1 
ATOM   6640 C CE1 . HIS F 3 16  ? -27.093 22.416  -58.484  1.00 114.31 ? 1360 HIS D CE1 1 
ATOM   6641 N NE2 . HIS F 3 16  ? -26.300 21.694  -57.714  1.00 122.15 ? 1360 HIS D NE2 1 
ATOM   6642 N N   . ASP F 3 17  ? -24.929 28.578  -57.286  1.00 79.39  ? 1361 ASP D N   1 
ATOM   6643 C CA  . ASP F 3 17  ? -24.369 29.664  -56.488  1.00 85.55  ? 1361 ASP D CA  1 
ATOM   6644 C C   . ASP F 3 17  ? -25.443 30.442  -55.737  1.00 92.99  ? 1361 ASP D C   1 
ATOM   6645 O O   . ASP F 3 17  ? -25.160 31.018  -54.680  1.00 105.33 ? 1361 ASP D O   1 
ATOM   6646 C CB  . ASP F 3 17  ? -23.559 30.608  -57.380  1.00 94.19  ? 1361 ASP D CB  1 
ATOM   6647 C CG  . ASP F 3 17  ? -22.101 30.192  -57.505  1.00 91.20  ? 1361 ASP D CG  1 
ATOM   6648 O OD1 . ASP F 3 17  ? -21.779 29.028  -57.178  1.00 87.52  ? 1361 ASP D OD1 1 
ATOM   6649 O OD2 . ASP F 3 17  ? -21.276 31.030  -57.931  1.00 77.93  ? 1361 ASP D OD2 1 
ATOM   6650 N N   . ILE F 3 18  ? -26.670 30.472  -56.251  1.00 82.60  ? 1362 ILE D N   1 
ATOM   6651 C CA  . ILE F 3 18  ? -27.746 31.277  -55.682  1.00 87.30  ? 1362 ILE D CA  1 
ATOM   6652 C C   . ILE F 3 18  ? -28.826 30.349  -55.148  1.00 84.78  ? 1362 ILE D C   1 
ATOM   6653 O O   . ILE F 3 18  ? -29.218 29.388  -55.822  1.00 86.75  ? 1362 ILE D O   1 
ATOM   6654 C CB  . ILE F 3 18  ? -28.331 32.257  -56.713  1.00 85.88  ? 1362 ILE D CB  1 
ATOM   6655 C CG1 . ILE F 3 18  ? -27.232 32.806  -57.623  1.00 74.53  ? 1362 ILE D CG1 1 
ATOM   6656 C CG2 . ILE F 3 18  ? -29.071 33.390  -56.016  1.00 88.68  ? 1362 ILE D CG2 1 
ATOM   6657 C CD1 . ILE F 3 18  ? -27.191 32.142  -58.981  1.00 71.86  ? 1362 ILE D CD1 1 
ATOM   6658 N N   . ASN F 3 19  ? -29.309 30.642  -53.944  1.00 80.61  ? 1363 ASN D N   1 
ATOM   6659 C CA  . ASN F 3 19  ? -30.407 29.910  -53.327  1.00 87.82  ? 1363 ASN D CA  1 
ATOM   6660 C C   . ASN F 3 19  ? -31.692 30.710  -53.482  1.00 83.34  ? 1363 ASN D C   1 
ATOM   6661 O O   . ASN F 3 19  ? -31.708 31.921  -53.239  1.00 74.56  ? 1363 ASN D O   1 
ATOM   6662 C CB  . ASN F 3 19  ? -30.129 29.644  -51.847  1.00 82.87  ? 1363 ASN D CB  1 
ATOM   6663 C CG  . ASN F 3 19  ? -29.542 28.269  -51.602  1.00 90.76  ? 1363 ASN D CG  1 
ATOM   6664 O OD1 . ASN F 3 19  ? -30.245 27.348  -51.186  1.00 105.42 ? 1363 ASN D OD1 1 
ATOM   6665 N ND2 . ASN F 3 19  ? -28.247 28.123  -51.859  1.00 91.32  ? 1363 ASN D ND2 1 
ATOM   6666 N N   . VAL F 3 20  ? -32.765 30.030  -53.881  1.00 74.31  ? 1364 VAL D N   1 
ATOM   6667 C CA  . VAL F 3 20  ? -34.062 30.659  -54.093  1.00 76.87  ? 1364 VAL D CA  1 
ATOM   6668 C C   . VAL F 3 20  ? -35.071 30.241  -53.028  1.00 84.03  ? 1364 VAL D C   1 
ATOM   6669 O O   . VAL F 3 20  ? -36.278 30.442  -53.207  1.00 81.92  ? 1364 VAL D O   1 
ATOM   6670 C CB  . VAL F 3 20  ? -34.586 30.371  -55.510  1.00 75.61  ? 1364 VAL D CB  1 
ATOM   6671 C CG1 . VAL F 3 20  ? -35.617 31.407  -55.940  1.00 75.86  ? 1364 VAL D CG1 1 
ATOM   6672 C CG2 . VAL F 3 20  ? -33.432 30.368  -56.483  1.00 70.18  ? 1364 VAL D CG2 1 
ATOM   6673 N N   . TYR F 3 21  ? -34.606 29.655  -51.921  1.00 72.54  ? 1365 TYR D N   1 
ATOM   6674 C CA  . TYR F 3 21  ? -35.486 29.424  -50.780  1.00 62.68  ? 1365 TYR D CA  1 
ATOM   6675 C C   . TYR F 3 21  ? -36.196 30.716  -50.393  1.00 67.63  ? 1365 TYR D C   1 
ATOM   6676 O O   . TYR F 3 21  ? -37.424 30.750  -50.249  1.00 69.95  ? 1365 TYR D O   1 
ATOM   6677 C CB  . TYR F 3 21  ? -34.678 28.863  -49.605  1.00 72.26  ? 1365 TYR D CB  1 
ATOM   6678 C CG  . TYR F 3 21  ? -35.480 28.253  -48.460  1.00 83.14  ? 1365 TYR D CG  1 
ATOM   6679 C CD1 . TYR F 3 21  ? -36.812 28.592  -48.238  1.00 71.81  ? 1365 TYR D CD1 1 
ATOM   6680 C CD2 . TYR F 3 21  ? -34.892 27.345  -47.590  1.00 77.38  ? 1365 TYR D CD2 1 
ATOM   6681 C CE1 . TYR F 3 21  ? -37.528 28.041  -47.192  1.00 66.85  ? 1365 TYR D CE1 1 
ATOM   6682 C CE2 . TYR F 3 21  ? -35.604 26.790  -46.544  1.00 85.07  ? 1365 TYR D CE2 1 
ATOM   6683 C CZ  . TYR F 3 21  ? -36.921 27.142  -46.349  1.00 90.96  ? 1365 TYR D CZ  1 
ATOM   6684 O OH  . TYR F 3 21  ? -37.632 26.591  -45.306  1.00 77.29  ? 1365 TYR D OH  1 
ATOM   6685 N N   . SER F 3 22  ? -35.437 31.799  -50.246  1.00 69.65  ? 1366 SER D N   1 
ATOM   6686 C CA  . SER F 3 22  ? -36.019 33.097  -49.948  1.00 70.60  ? 1366 SER D CA  1 
ATOM   6687 C C   . SER F 3 22  ? -35.212 34.179  -50.648  1.00 75.33  ? 1366 SER D C   1 
ATOM   6688 O O   . SER F 3 22  ? -34.144 33.927  -51.214  1.00 59.65  ? 1366 SER D O   1 
ATOM   6689 C CB  . SER F 3 22  ? -36.076 33.355  -48.438  1.00 57.55  ? 1366 SER D CB  1 
ATOM   6690 O OG  . SER F 3 22  ? -36.691 34.602  -48.159  1.00 53.90  ? 1366 SER D OG  1 
ATOM   6691 N N   . LEU F 3 23  ? -35.747 35.401  -50.599  1.00 74.05  ? 1367 LEU D N   1 
ATOM   6692 C CA  . LEU F 3 23  ? -35.054 36.561  -51.145  1.00 64.18  ? 1367 LEU D CA  1 
ATOM   6693 C C   . LEU F 3 23  ? -33.777 36.874  -50.376  1.00 71.00  ? 1367 LEU D C   1 
ATOM   6694 O O   . LEU F 3 23  ? -32.941 37.640  -50.869  1.00 73.33  ? 1367 LEU D O   1 
ATOM   6695 C CB  . LEU F 3 23  ? -35.981 37.779  -51.146  1.00 54.21  ? 1367 LEU D CB  1 
ATOM   6696 C CG  . LEU F 3 23  ? -37.429 37.617  -51.629  1.00 52.41  ? 1367 LEU D CG  1 
ATOM   6697 C CD1 . LEU F 3 23  ? -38.363 37.098  -50.530  1.00 57.86  ? 1367 LEU D CD1 1 
ATOM   6698 C CD2 . LEU F 3 23  ? -37.950 38.928  -52.194  1.00 57.24  ? 1367 LEU D CD2 1 
ATOM   6699 N N   . ALA F 3 24  ? -33.614 36.307  -49.177  1.00 76.35  ? 1368 ALA D N   1 
ATOM   6700 C CA  . ALA F 3 24  ? -32.344 36.416  -48.472  1.00 65.46  ? 1368 ALA D CA  1 
ATOM   6701 C C   . ALA F 3 24  ? -31.215 35.780  -49.269  1.00 76.31  ? 1368 ALA D C   1 
ATOM   6702 O O   . ALA F 3 24  ? -30.059 36.195  -49.142  1.00 95.17  ? 1368 ALA D O   1 
ATOM   6703 C CB  . ALA F 3 24  ? -32.449 35.768  -47.092  1.00 68.40  ? 1368 ALA D CB  1 
ATOM   6704 N N   . GLY F 3 25  ? -31.529 34.771  -50.089  1.00 75.01  ? 1369 GLY D N   1 
ATOM   6705 C CA  . GLY F 3 25  ? -30.522 34.190  -50.960  1.00 87.27  ? 1369 GLY D CA  1 
ATOM   6706 C C   . GLY F 3 25  ? -29.903 35.201  -51.904  1.00 84.23  ? 1369 GLY D C   1 
ATOM   6707 O O   . GLY F 3 25  ? -28.755 35.039  -52.326  1.00 76.36  ? 1369 GLY D O   1 
ATOM   6708 N N   . LEU F 3 26  ? -30.653 36.249  -52.256  1.00 83.89  ? 1370 LEU D N   1 
ATOM   6709 C CA  . LEU F 3 26  ? -30.064 37.361  -52.994  1.00 82.77  ? 1370 LEU D CA  1 
ATOM   6710 C C   . LEU F 3 26  ? -28.928 37.995  -52.201  1.00 95.87  ? 1370 LEU D C   1 
ATOM   6711 O O   . LEU F 3 26  ? -27.784 38.048  -52.670  1.00 103.80 ? 1370 LEU D O   1 
ATOM   6712 C CB  . LEU F 3 26  ? -31.137 38.402  -53.329  1.00 62.53  ? 1370 LEU D CB  1 
ATOM   6713 C CG  . LEU F 3 26  ? -32.013 38.151  -54.561  1.00 73.12  ? 1370 LEU D CG  1 
ATOM   6714 C CD1 . LEU F 3 26  ? -33.214 39.090  -54.584  1.00 59.21  ? 1370 LEU D CD1 1 
ATOM   6715 C CD2 . LEU F 3 26  ? -31.202 38.295  -55.837  1.00 85.11  ? 1370 LEU D CD2 1 
ATOM   6716 N N   . ALA F 3 27  ? -29.226 38.435  -50.964  1.00 90.56  ? 1371 ALA D N   1 
ATOM   6717 C CA  . ALA F 3 27  ? -28.410 39.263  -50.069  1.00 75.78  ? 1371 ALA D CA  1 
ATOM   6718 C C   . ALA F 3 27  ? -26.900 39.033  -50.145  1.00 74.22  ? 1371 ALA D C   1 
ATOM   6719 O O   . ALA F 3 27  ? -26.155 40.015  -50.260  1.00 73.06  ? 1371 ALA D O   1 
ATOM   6720 C CB  . ALA F 3 27  ? -28.884 39.082  -48.621  1.00 70.86  ? 1371 ALA D CB  1 
ATOM   6721 N N   . PRO F 3 28  ? -26.393 37.792  -50.076  1.00 74.87  ? 1372 PRO D N   1 
ATOM   6722 C CA  . PRO F 3 28  ? -24.930 37.628  -50.064  1.00 76.86  ? 1372 PRO D CA  1 
ATOM   6723 C C   . PRO F 3 28  ? -24.251 38.025  -51.363  1.00 94.03  ? 1372 PRO D C   1 
ATOM   6724 O O   . PRO F 3 28  ? -23.120 38.527  -51.323  1.00 104.00 ? 1372 PRO D O   1 
ATOM   6725 C CB  . PRO F 3 28  ? -24.740 36.132  -49.779  1.00 70.59  ? 1372 PRO D CB  1 
ATOM   6726 C CG  . PRO F 3 28  ? -26.006 35.503  -50.204  1.00 80.84  ? 1372 PRO D CG  1 
ATOM   6727 C CD  . PRO F 3 28  ? -27.070 36.496  -49.885  1.00 82.31  ? 1372 PRO D CD  1 
ATOM   6728 N N   . HIS F 3 29  ? -24.895 37.824  -52.514  1.00 102.14 ? 1373 HIS D N   1 
ATOM   6729 C CA  . HIS F 3 29  ? -24.198 37.987  -53.785  1.00 89.79  ? 1373 HIS D CA  1 
ATOM   6730 C C   . HIS F 3 29  ? -24.188 39.420  -54.308  1.00 100.86 ? 1373 HIS D C   1 
ATOM   6731 O O   . HIS F 3 29  ? -23.465 39.684  -55.275  1.00 104.80 ? 1373 HIS D O   1 
ATOM   6732 C CB  . HIS F 3 29  ? -24.803 37.083  -54.858  1.00 77.29  ? 1373 HIS D CB  1 
ATOM   6733 C CG  . HIS F 3 29  ? -25.081 35.688  -54.399  1.00 86.60  ? 1373 HIS D CG  1 
ATOM   6734 N ND1 . HIS F 3 29  ? -26.312 35.296  -53.919  1.00 89.45  ? 1373 HIS D ND1 1 
ATOM   6735 C CD2 . HIS F 3 29  ? -24.295 34.586  -54.363  1.00 86.26  ? 1373 HIS D CD2 1 
ATOM   6736 C CE1 . HIS F 3 29  ? -26.269 34.015  -53.596  1.00 93.80  ? 1373 HIS D CE1 1 
ATOM   6737 N NE2 . HIS F 3 29  ? -25.056 33.561  -53.856  1.00 97.87  ? 1373 HIS D NE2 1 
ATOM   6738 N N   . ILE F 3 30  ? -24.964 40.342  -53.718  1.00 96.27  ? 1374 ILE D N   1 
ATOM   6739 C CA  . ILE F 3 30  ? -24.940 41.725  -54.191  1.00 96.07  ? 1374 ILE D CA  1 
ATOM   6740 C C   . ILE F 3 30  ? -23.532 42.287  -54.089  1.00 102.46 ? 1374 ILE D C   1 
ATOM   6741 O O   . ILE F 3 30  ? -22.871 42.182  -53.050  1.00 97.36  ? 1374 ILE D O   1 
ATOM   6742 C CB  . ILE F 3 30  ? -25.941 42.627  -53.444  1.00 80.82  ? 1374 ILE D CB  1 
ATOM   6743 C CG1 . ILE F 3 30  ? -27.407 42.262  -53.691  1.00 80.07  ? 1374 ILE D CG1 1 
ATOM   6744 C CG2 . ILE F 3 30  ? -25.708 44.087  -53.779  1.00 91.32  ? 1374 ILE D CG2 1 
ATOM   6745 C CD1 . ILE F 3 30  ? -27.901 41.071  -52.994  1.00 72.20  ? 1374 ILE D CD1 1 
ATOM   6746 N N   . THR F 3 31  ? -23.068 42.890  -55.179  1.00 106.67 ? 1375 THR D N   1 
ATOM   6747 C CA  . THR F 3 31  ? -21.765 43.540  -55.209  1.00 110.60 ? 1375 THR D CA  1 
ATOM   6748 C C   . THR F 3 31  ? -21.882 44.953  -54.651  1.00 132.69 ? 1375 THR D C   1 
ATOM   6749 O O   . THR F 3 31  ? -22.877 45.647  -54.885  1.00 129.44 ? 1375 THR D O   1 
ATOM   6750 C CB  . THR F 3 31  ? -21.221 43.574  -56.637  1.00 100.09 ? 1375 THR D CB  1 
ATOM   6751 O OG1 . THR F 3 31  ? -21.765 44.706  -57.324  1.00 101.33 ? 1375 THR D OG1 1 
ATOM   6752 C CG2 . THR F 3 31  ? -21.613 42.297  -57.381  1.00 68.08  ? 1375 THR D CG2 1 
ATOM   6753 N N   . LEU F 3 32  ? -20.857 45.372  -53.909  1.00 138.06 ? 1376 LEU D N   1 
ATOM   6754 C CA  . LEU F 3 32  ? -20.892 46.672  -53.250  1.00 137.49 ? 1376 LEU D CA  1 
ATOM   6755 C C   . LEU F 3 32  ? -20.571 47.804  -54.219  1.00 144.45 ? 1376 LEU D C   1 
ATOM   6756 O O   . LEU F 3 32  ? -21.340 48.765  -54.335  1.00 133.38 ? 1376 LEU D O   1 
ATOM   6757 C CB  . LEU F 3 32  ? -19.916 46.689  -52.071  1.00 128.98 ? 1376 LEU D CB  1 
ATOM   6758 C CG  . LEU F 3 32  ? -20.052 47.835  -51.065  1.00 128.41 ? 1376 LEU D CG  1 
ATOM   6759 C CD1 . LEU F 3 32  ? -21.512 48.077  -50.708  1.00 111.67 ? 1376 LEU D CD1 1 
ATOM   6760 C CD2 . LEU F 3 32  ? -19.228 47.564  -49.811  1.00 88.35  ? 1376 LEU D CD2 1 
ATOM   6761 N N   . ASN F 3 33  ? -19.440 47.698  -54.928  1.00 149.92 ? 1377 ASN D N   1 
ATOM   6762 C CA  . ASN F 3 33  ? -18.842 48.784  -55.702  1.00 149.79 ? 1377 ASN D CA  1 
ATOM   6763 C C   . ASN F 3 33  ? -18.772 50.028  -54.823  1.00 149.84 ? 1377 ASN D C   1 
ATOM   6764 O O   . ASN F 3 33  ? -19.589 50.949  -54.969  1.00 136.60 ? 1377 ASN D O   1 
ATOM   6765 C CB  . ASN F 3 33  ? -19.623 49.065  -56.988  1.00 146.35 ? 1377 ASN D CB  1 
ATOM   6766 C CG  . ASN F 3 33  ? -18.744 48.995  -58.227  1.00 128.06 ? 1377 ASN D CG  1 
ATOM   6767 O OD1 . ASN F 3 33  ? -17.942 48.074  -58.380  1.00 128.43 ? 1377 ASN D OD1 1 
ATOM   6768 N ND2 . ASN F 3 33  ? -18.860 49.992  -59.095  1.00 108.98 ? 1377 ASN D ND2 1 
ATOM   6769 N N   . PRO F 3 34  ? -17.804 50.088  -53.905  1.00 154.46 ? 1378 PRO D N   1 
ATOM   6770 C CA  . PRO F 3 34  ? -17.847 51.111  -52.849  1.00 142.46 ? 1378 PRO D CA  1 
ATOM   6771 C C   . PRO F 3 34  ? -17.554 52.520  -53.329  1.00 145.21 ? 1378 PRO D C   1 
ATOM   6772 O O   . PRO F 3 34  ? -17.886 53.470  -52.612  1.00 147.22 ? 1378 PRO D O   1 
ATOM   6773 C CB  . PRO F 3 34  ? -16.777 50.635  -51.854  1.00 126.15 ? 1378 PRO D CB  1 
ATOM   6774 C CG  . PRO F 3 34  ? -16.501 49.197  -52.226  1.00 130.79 ? 1378 PRO D CG  1 
ATOM   6775 C CD  . PRO F 3 34  ? -16.698 49.140  -53.704  1.00 140.39 ? 1378 PRO D CD  1 
ATOM   6776 N N   . THR F 3 35  ? -16.924 52.696  -54.487  1.00 145.95 ? 1379 THR D N   1 
ATOM   6777 C CA  . THR F 3 35  ? -16.760 54.035  -55.039  1.00 138.12 ? 1379 THR D CA  1 
ATOM   6778 C C   . THR F 3 35  ? -18.107 54.517  -55.566  1.00 136.30 ? 1379 THR D C   1 
ATOM   6779 O O   . THR F 3 35  ? -18.703 53.878  -56.439  1.00 141.87 ? 1379 THR D O   1 
ATOM   6780 C CB  . THR F 3 35  ? -15.710 54.042  -56.148  1.00 125.32 ? 1379 THR D CB  1 
ATOM   6781 O OG1 . THR F 3 35  ? -16.260 54.641  -57.328  1.00 127.42 ? 1379 THR D OG1 1 
ATOM   6782 C CG2 . THR F 3 35  ? -15.253 52.625  -56.468  1.00 107.95 ? 1379 THR D CG2 1 
ATOM   6783 N N   . ILE F 3 36  ? -18.594 55.631  -55.029  1.00 130.06 ? 1380 ILE D N   1 
ATOM   6784 C CA  . ILE F 3 36  ? -19.960 56.077  -55.298  1.00 128.24 ? 1380 ILE D CA  1 
ATOM   6785 C C   . ILE F 3 36  ? -20.050 57.598  -55.291  1.00 131.75 ? 1380 ILE D C   1 
ATOM   6786 O O   . ILE F 3 36  ? -19.156 58.275  -54.761  1.00 126.25 ? 1380 ILE D O   1 
ATOM   6787 C CB  . ILE F 3 36  ? -20.958 55.471  -54.292  1.00 130.97 ? 1380 ILE D CB  1 
ATOM   6788 C CG1 . ILE F 3 36  ? -20.309 55.193  -52.932  1.00 123.14 ? 1380 ILE D CG1 1 
ATOM   6789 C CG2 . ILE F 3 36  ? -21.575 54.195  -54.851  1.00 127.02 ? 1380 ILE D CG2 1 
ATOM   6790 C CD1 . ILE F 3 36  ? -19.613 56.363  -52.274  1.00 114.93 ? 1380 ILE D CD1 1 
ATOM   6791 N N   . PRO F 3 37  ? -21.099 58.175  -55.882  1.00 144.19 ? 1381 PRO D N   1 
ATOM   6792 C CA  . PRO F 3 37  ? -21.315 59.621  -55.777  1.00 149.24 ? 1381 PRO D CA  1 
ATOM   6793 C C   . PRO F 3 37  ? -22.098 60.062  -54.551  1.00 134.07 ? 1381 PRO D C   1 
ATOM   6794 O O   . PRO F 3 37  ? -22.177 61.273  -54.301  1.00 119.16 ? 1381 PRO D O   1 
ATOM   6795 C CB  . PRO F 3 37  ? -22.106 59.942  -57.064  1.00 136.72 ? 1381 PRO D CB  1 
ATOM   6796 C CG  . PRO F 3 37  ? -22.029 58.703  -57.915  1.00 133.84 ? 1381 PRO D CG  1 
ATOM   6797 C CD  . PRO F 3 37  ? -21.921 57.583  -56.947  1.00 138.29 ? 1381 PRO D CD  1 
ATOM   6798 N N   . LEU F 3 38  ? -22.675 59.139  -53.786  1.00 130.67 ? 1382 LEU D N   1 
ATOM   6799 C CA  . LEU F 3 38  ? -23.495 59.527  -52.646  1.00 136.68 ? 1382 LEU D CA  1 
ATOM   6800 C C   . LEU F 3 38  ? -22.998 58.939  -51.336  1.00 137.29 ? 1382 LEU D C   1 
ATOM   6801 O O   . LEU F 3 38  ? -22.790 59.689  -50.376  1.00 151.72 ? 1382 LEU D O   1 
ATOM   6802 C CB  . LEU F 3 38  ? -24.963 59.130  -52.895  1.00 123.62 ? 1382 LEU D CB  1 
ATOM   6803 C CG  . LEU F 3 38  ? -26.029 59.442  -51.835  1.00 124.03 ? 1382 LEU D CG  1 
ATOM   6804 C CD1 . LEU F 3 38  ? -26.027 58.452  -50.679  1.00 131.49 ? 1382 LEU D CD1 1 
ATOM   6805 C CD2 . LEU F 3 38  ? -25.901 60.862  -51.314  1.00 126.77 ? 1382 LEU D CD2 1 
ATOM   6806 N N   . PHE F 3 39  ? -22.802 57.617  -51.263  1.00 131.89 ? 1383 PHE D N   1 
ATOM   6807 C CA  . PHE F 3 39  ? -22.514 56.960  -49.987  1.00 148.78 ? 1383 PHE D CA  1 
ATOM   6808 C C   . PHE F 3 39  ? -21.264 57.507  -49.309  1.00 149.12 ? 1383 PHE D C   1 
ATOM   6809 O O   . PHE F 3 39  ? -21.049 57.228  -48.123  1.00 144.33 ? 1383 PHE D O   1 
ATOM   6810 C CB  . PHE F 3 39  ? -22.345 55.444  -50.166  1.00 149.62 ? 1383 PHE D CB  1 
ATOM   6811 C CG  . PHE F 3 39  ? -23.535 54.740  -50.781  1.00 158.18 ? 1383 PHE D CG  1 
ATOM   6812 C CD1 . PHE F 3 39  ? -24.719 55.409  -51.050  1.00 167.53 ? 1383 PHE D CD1 1 
ATOM   6813 C CD2 . PHE F 3 39  ? -23.452 53.395  -51.101  1.00 146.64 ? 1383 PHE D CD2 1 
ATOM   6814 C CE1 . PHE F 3 39  ? -25.795 54.752  -51.619  1.00 165.16 ? 1383 PHE D CE1 1 
ATOM   6815 C CE2 . PHE F 3 39  ? -24.522 52.732  -51.671  1.00 164.84 ? 1383 PHE D CE2 1 
ATOM   6816 C CZ  . PHE F 3 39  ? -25.696 53.411  -51.928  1.00 169.17 ? 1383 PHE D CZ  1 
ATOM   6817 N N   . GLN F 3 40  ? -20.439 58.265  -50.026  1.00 145.51 ? 1384 GLN D N   1 
ATOM   6818 C CA  . GLN F 3 40  ? -19.255 58.883  -49.453  1.00 139.56 ? 1384 GLN D CA  1 
ATOM   6819 C C   . GLN F 3 40  ? -19.672 60.116  -48.662  1.00 151.94 ? 1384 GLN D C   1 
ATOM   6820 O O   . GLN F 3 40  ? -20.404 60.971  -49.174  1.00 159.61 ? 1384 GLN D O   1 
ATOM   6821 C CB  . GLN F 3 40  ? -18.266 59.246  -50.559  1.00 125.69 ? 1384 GLN D CB  1 
ATOM   6822 C CG  . GLN F 3 40  ? -16.878 59.614  -50.079  1.00 124.00 ? 1384 GLN D CG  1 
ATOM   6823 C CD  . GLN F 3 40  ? -16.581 61.090  -50.247  1.00 140.65 ? 1384 GLN D CD  1 
ATOM   6824 O OE1 . GLN F 3 40  ? -17.352 61.944  -49.812  1.00 163.87 ? 1384 GLN D OE1 1 
ATOM   6825 N NE2 . GLN F 3 40  ? -15.464 61.397  -50.896  1.00 123.71 ? 1384 GLN D NE2 1 
ATOM   6826 N N   . ALA F 3 41  ? -19.215 60.194  -47.411  1.00 156.34 ? 1385 ALA D N   1 
ATOM   6827 C CA  . ALA F 3 41  ? -19.713 61.139  -46.410  1.00 148.12 ? 1385 ALA D CA  1 
ATOM   6828 C C   . ALA F 3 41  ? -21.195 60.923  -46.112  1.00 152.67 ? 1385 ALA D C   1 
ATOM   6829 O O   . ALA F 3 41  ? -21.853 61.802  -45.544  1.00 148.63 ? 1385 ALA D O   1 
ATOM   6830 C CB  . ALA F 3 41  ? -19.454 62.595  -46.817  1.00 128.65 ? 1385 ALA D CB  1 
ATOM   6831 N N   . HIS F 3 42  ? -21.726 59.759  -46.489  1.00 158.74 ? 1386 HIS D N   1 
ATOM   6832 C CA  . HIS F 3 42  ? -23.108 59.375  -46.197  1.00 152.24 ? 1386 HIS D CA  1 
ATOM   6833 C C   . HIS F 3 42  ? -23.149 57.878  -45.919  1.00 153.96 ? 1386 HIS D C   1 
ATOM   6834 O O   . HIS F 3 42  ? -23.583 57.085  -46.763  1.00 150.95 ? 1386 HIS D O   1 
ATOM   6835 C CB  . HIS F 3 42  ? -24.047 59.730  -47.355  1.00 138.50 ? 1386 HIS D CB  1 
ATOM   6836 C CG  . HIS F 3 42  ? -24.145 61.197  -47.642  1.00 133.79 ? 1386 HIS D CG  1 
ATOM   6837 N ND1 . HIS F 3 42  ? -23.205 61.877  -48.386  1.00 133.31 ? 1386 HIS D ND1 1 
ATOM   6838 C CD2 . HIS F 3 42  ? -25.083 62.111  -47.298  1.00 127.33 ? 1386 HIS D CD2 1 
ATOM   6839 C CE1 . HIS F 3 42  ? -23.555 63.147  -48.481  1.00 126.81 ? 1386 HIS D CE1 1 
ATOM   6840 N NE2 . HIS F 3 42  ? -24.691 63.316  -47.830  1.00 132.17 ? 1386 HIS D NE2 1 
ATOM   6841 N N   . PRO F 3 43  ? -22.700 57.450  -44.733  1.00 162.86 ? 1387 PRO D N   1 
ATOM   6842 C CA  . PRO F 3 43  ? -22.767 56.016  -44.396  1.00 152.98 ? 1387 PRO D CA  1 
ATOM   6843 C C   . PRO F 3 43  ? -24.186 55.496  -44.234  1.00 159.40 ? 1387 PRO D C   1 
ATOM   6844 O O   . PRO F 3 43  ? -24.370 54.278  -44.105  1.00 138.97 ? 1387 PRO D O   1 
ATOM   6845 C CB  . PRO F 3 43  ? -21.998 55.927  -43.067  1.00 128.16 ? 1387 PRO D CB  1 
ATOM   6846 C CG  . PRO F 3 43  ? -21.240 57.223  -42.955  1.00 137.30 ? 1387 PRO D CG  1 
ATOM   6847 C CD  . PRO F 3 43  ? -22.098 58.235  -43.643  1.00 162.46 ? 1387 PRO D CD  1 
ATOM   6848 N N   . GLN F 3 44  ? -25.185 56.379  -44.255  1.00 163.32 ? 1388 GLN D N   1 
ATOM   6849 C CA  . GLN F 3 44  ? -26.555 56.010  -43.924  1.00 153.50 ? 1388 GLN D CA  1 
ATOM   6850 C C   . GLN F 3 44  ? -27.305 55.399  -45.103  1.00 156.38 ? 1388 GLN D C   1 
ATOM   6851 O O   . GLN F 3 44  ? -28.229 54.605  -44.893  1.00 148.88 ? 1388 GLN D O   1 
ATOM   6852 C CB  . GLN F 3 44  ? -27.303 57.245  -43.419  1.00 151.62 ? 1388 GLN D CB  1 
ATOM   6853 C CG  . GLN F 3 44  ? -26.724 58.550  -43.955  1.00 136.04 ? 1388 GLN D CG  1 
ATOM   6854 C CD  . GLN F 3 44  ? -27.254 59.776  -43.241  1.00 127.81 ? 1388 GLN D CD  1 
ATOM   6855 O OE1 . GLN F 3 44  ? -27.465 59.762  -42.029  1.00 109.97 ? 1388 GLN D OE1 1 
ATOM   6856 N NE2 . GLN F 3 44  ? -27.469 60.849  -43.994  1.00 126.16 ? 1388 GLN D NE2 1 
ATOM   6857 N N   . LEU F 3 45  ? -26.934 55.746  -46.336  1.00 161.36 ? 1389 LEU D N   1 
ATOM   6858 C CA  . LEU F 3 45  ? -27.724 55.388  -47.507  1.00 154.84 ? 1389 LEU D CA  1 
ATOM   6859 C C   . LEU F 3 45  ? -27.150 54.225  -48.309  1.00 157.24 ? 1389 LEU D C   1 
ATOM   6860 O O   . LEU F 3 45  ? -27.728 53.868  -49.341  1.00 150.05 ? 1389 LEU D O   1 
ATOM   6861 C CB  . LEU F 3 45  ? -27.902 56.604  -48.423  1.00 137.74 ? 1389 LEU D CB  1 
ATOM   6862 C CG  . LEU F 3 45  ? -29.061 57.562  -48.117  1.00 127.82 ? 1389 LEU D CG  1 
ATOM   6863 C CD1 . LEU F 3 45  ? -28.805 58.374  -46.853  1.00 146.26 ? 1389 LEU D CD1 1 
ATOM   6864 C CD2 . LEU F 3 45  ? -29.363 58.483  -49.296  1.00 105.97 ? 1389 LEU D CD2 1 
ATOM   6865 N N   . LYS F 3 46  ? -26.030 53.631  -47.878  1.00 152.96 ? 1390 LYS D N   1 
ATOM   6866 C CA  . LYS F 3 46  ? -25.609 52.349  -48.443  1.00 140.26 ? 1390 LYS D CA  1 
ATOM   6867 C C   . LYS F 3 46  ? -26.716 51.321  -48.328  1.00 150.95 ? 1390 LYS D C   1 
ATOM   6868 O O   . LYS F 3 46  ? -26.826 50.406  -49.154  1.00 154.52 ? 1390 LYS D O   1 
ATOM   6869 C CB  . LYS F 3 46  ? -24.342 51.852  -47.724  1.00 116.84 ? 1390 LYS D CB  1 
ATOM   6870 C CG  . LYS F 3 46  ? -24.339 50.363  -47.301  1.00 114.45 ? 1390 LYS D CG  1 
ATOM   6871 C CD  . LYS F 3 46  ? -24.058 49.384  -48.438  1.00 97.30  ? 1390 LYS D CD  1 
ATOM   6872 C CE  . LYS F 3 46  ? -24.203 47.939  -47.965  1.00 93.85  ? 1390 LYS D CE  1 
ATOM   6873 N NZ  . LYS F 3 46  ? -25.576 47.616  -47.467  1.00 92.87  ? 1390 LYS D NZ  1 
ATOM   6874 N N   . GLN F 3 47  ? -27.573 51.500  -47.348  1.00 148.95 ? 1391 GLN D N   1 
ATOM   6875 C CA  . GLN F 3 47  ? -28.346 50.421  -46.785  1.00 139.92 ? 1391 GLN D CA  1 
ATOM   6876 C C   . GLN F 3 47  ? -29.779 50.401  -47.326  1.00 133.96 ? 1391 GLN D C   1 
ATOM   6877 O O   . GLN F 3 47  ? -30.541 49.483  -47.005  1.00 137.90 ? 1391 GLN D O   1 
ATOM   6878 C CB  . GLN F 3 47  ? -28.250 50.591  -45.257  1.00 141.74 ? 1391 GLN D CB  1 
ATOM   6879 C CG  . GLN F 3 47  ? -26.780 50.462  -44.713  1.00 139.17 ? 1391 GLN D CG  1 
ATOM   6880 C CD  . GLN F 3 47  ? -26.649 49.916  -43.291  1.00 141.35 ? 1391 GLN D CD  1 
ATOM   6881 O OE1 . GLN F 3 47  ? -26.742 48.703  -43.072  1.00 143.03 ? 1391 GLN D OE1 1 
ATOM   6882 N NE2 . GLN F 3 47  ? -26.427 50.804  -42.327  1.00 136.72 ? 1391 GLN D NE2 1 
ATOM   6883 N N   . CYS F 3 48  ? -30.133 51.360  -48.191  1.00 124.11 ? 1392 CYS D N   1 
ATOM   6884 C CA  . CYS F 3 48  ? -31.431 51.373  -48.862  1.00 132.20 ? 1392 CYS D CA  1 
ATOM   6885 C C   . CYS F 3 48  ? -31.504 50.388  -50.028  1.00 130.69 ? 1392 CYS D C   1 
ATOM   6886 O O   . CYS F 3 48  ? -32.611 50.043  -50.456  1.00 129.06 ? 1392 CYS D O   1 
ATOM   6887 C CB  . CYS F 3 48  ? -31.749 52.795  -49.366  1.00 126.65 ? 1392 CYS D CB  1 
ATOM   6888 S SG  . CYS F 3 48  ? -33.401 53.076  -50.107  1.00 103.37 ? 1392 CYS D SG  1 
ATOM   6889 N N   . VAL F 3 49  ? -30.363 49.901  -50.529  1.00 140.60 ? 1393 VAL D N   1 
ATOM   6890 C CA  . VAL F 3 49  ? -30.354 49.206  -51.817  1.00 142.18 ? 1393 VAL D CA  1 
ATOM   6891 C C   . VAL F 3 49  ? -30.890 47.771  -51.725  1.00 132.72 ? 1393 VAL D C   1 
ATOM   6892 O O   . VAL F 3 49  ? -31.544 47.294  -52.661  1.00 135.85 ? 1393 VAL D O   1 
ATOM   6893 C CB  . VAL F 3 49  ? -28.942 49.244  -52.431  1.00 136.75 ? 1393 VAL D CB  1 
ATOM   6894 C CG1 . VAL F 3 49  ? -28.453 50.684  -52.531  1.00 140.57 ? 1393 VAL D CG1 1 
ATOM   6895 C CG2 . VAL F 3 49  ? -27.956 48.387  -51.634  1.00 107.01 ? 1393 VAL D CG2 1 
ATOM   6896 N N   . ARG F 3 50  ? -30.643 47.062  -50.620  1.00 123.94 ? 1394 ARG D N   1 
ATOM   6897 C CA  . ARG F 3 50  ? -30.999 45.645  -50.559  1.00 111.26 ? 1394 ARG D CA  1 
ATOM   6898 C C   . ARG F 3 50  ? -32.508 45.438  -50.648  1.00 106.69 ? 1394 ARG D C   1 
ATOM   6899 O O   . ARG F 3 50  ? -32.983 44.594  -51.416  1.00 119.55 ? 1394 ARG D O   1 
ATOM   6900 C CB  . ARG F 3 50  ? -30.443 45.015  -49.283  1.00 115.84 ? 1394 ARG D CB  1 
ATOM   6901 C CG  . ARG F 3 50  ? -30.719 43.523  -49.163  1.00 110.64 ? 1394 ARG D CG  1 
ATOM   6902 C CD  . ARG F 3 50  ? -31.858 43.298  -48.184  1.00 106.37 ? 1394 ARG D CD  1 
ATOM   6903 N NE  . ARG F 3 50  ? -32.115 41.889  -47.919  1.00 104.42 ? 1394 ARG D NE  1 
ATOM   6904 C CZ  . ARG F 3 50  ? -31.663 41.235  -46.857  1.00 91.22  ? 1394 ARG D CZ  1 
ATOM   6905 N NH1 . ARG F 3 50  ? -30.881 41.822  -45.965  1.00 84.18  ? 1394 ARG D NH1 1 
ATOM   6906 N NH2 . ARG F 3 50  ? -31.995 39.957  -46.692  1.00 89.62  ? 1394 ARG D NH2 1 
ATOM   6907 N N   . GLN F 3 51  ? -33.282 46.191  -49.858  1.00 109.14 ? 1395 GLN D N   1 
ATOM   6908 C CA  . GLN F 3 51  ? -34.734 46.034  -49.893  1.00 110.86 ? 1395 GLN D CA  1 
ATOM   6909 C C   . GLN F 3 51  ? -35.301 46.350  -51.271  1.00 101.36 ? 1395 GLN D C   1 
ATOM   6910 O O   . GLN F 3 51  ? -36.311 45.765  -51.673  1.00 106.03 ? 1395 GLN D O   1 
ATOM   6911 C CB  . GLN F 3 51  ? -35.394 46.916  -48.831  1.00 109.25 ? 1395 GLN D CB  1 
ATOM   6912 C CG  . GLN F 3 51  ? -35.190 48.410  -49.036  1.00 119.87 ? 1395 GLN D CG  1 
ATOM   6913 C CD  . GLN F 3 51  ? -34.279 49.024  -47.991  1.00 129.06 ? 1395 GLN D CD  1 
ATOM   6914 O OE1 . GLN F 3 51  ? -33.128 48.617  -47.839  1.00 133.59 ? 1395 GLN D OE1 1 
ATOM   6915 N NE2 . GLN F 3 51  ? -34.791 50.013  -47.268  1.00 123.18 ? 1395 GLN D NE2 1 
ATOM   6916 N N   . ALA F 3 52  ? -34.661 47.258  -52.014  1.00 93.52  ? 1396 ALA D N   1 
ATOM   6917 C CA  . ALA F 3 52  ? -35.145 47.597  -53.349  1.00 104.85 ? 1396 ALA D CA  1 
ATOM   6918 C C   . ALA F 3 52  ? -34.870 46.474  -54.343  1.00 101.34 ? 1396 ALA D C   1 
ATOM   6919 O O   . ALA F 3 52  ? -35.716 46.171  -55.193  1.00 92.94  ? 1396 ALA D O   1 
ATOM   6920 C CB  . ALA F 3 52  ? -34.510 48.904  -53.823  1.00 103.96 ? 1396 ALA D CB  1 
ATOM   6921 N N   . ILE F 3 53  ? -33.688 45.854  -54.261  1.00 99.63  ? 1397 ILE D N   1 
ATOM   6922 C CA  . ILE F 3 53  ? -33.370 44.727  -55.137  1.00 87.80  ? 1397 ILE D CA  1 
ATOM   6923 C C   . ILE F 3 53  ? -34.369 43.597  -54.922  1.00 87.94  ? 1397 ILE D C   1 
ATOM   6924 O O   . ILE F 3 53  ? -34.904 43.024  -55.878  1.00 101.91 ? 1397 ILE D O   1 
ATOM   6925 C CB  . ILE F 3 53  ? -31.924 44.249  -54.902  1.00 96.34  ? 1397 ILE D CB  1 
ATOM   6926 C CG1 . ILE F 3 53  ? -30.919 45.340  -55.283  1.00 100.52 ? 1397 ILE D CG1 1 
ATOM   6927 C CG2 . ILE F 3 53  ? -31.648 42.970  -55.682  1.00 83.58  ? 1397 ILE D CG2 1 
ATOM   6928 C CD1 . ILE F 3 53  ? -29.534 45.129  -54.695  1.00 89.58  ? 1397 ILE D CD1 1 
ATOM   6929 N N   . GLU F 3 54  ? -34.633 43.262  -53.657  1.00 84.85  ? 1398 GLU D N   1 
ATOM   6930 C CA  . GLU F 3 54  ? -35.654 42.268  -53.348  1.00 77.57  ? 1398 GLU D CA  1 
ATOM   6931 C C   . GLU F 3 54  ? -37.039 42.766  -53.740  1.00 75.04  ? 1398 GLU D C   1 
ATOM   6932 O O   . GLU F 3 54  ? -37.877 41.984  -54.207  1.00 75.33  ? 1398 GLU D O   1 
ATOM   6933 C CB  . GLU F 3 54  ? -35.616 41.925  -51.860  1.00 79.62  ? 1398 GLU D CB  1 
ATOM   6934 C CG  . GLU F 3 54  ? -34.471 41.020  -51.447  1.00 85.51  ? 1398 GLU D CG  1 
ATOM   6935 C CD  . GLU F 3 54  ? -34.509 40.687  -49.967  1.00 99.28  ? 1398 GLU D CD  1 
ATOM   6936 O OE1 . GLU F 3 54  ? -35.506 41.048  -49.305  1.00 92.14  ? 1398 GLU D OE1 1 
ATOM   6937 O OE2 . GLU F 3 54  ? -33.548 40.065  -49.466  1.00 98.77  ? 1398 GLU D OE2 1 
ATOM   6938 N N   . ARG F 3 55  ? -37.299 44.063  -53.547  1.00 73.66  ? 1399 ARG D N   1 
ATOM   6939 C CA  . ARG F 3 55  ? -38.589 44.630  -53.930  1.00 74.72  ? 1399 ARG D CA  1 
ATOM   6940 C C   . ARG F 3 55  ? -38.874 44.396  -55.405  1.00 80.60  ? 1399 ARG D C   1 
ATOM   6941 O O   . ARG F 3 55  ? -40.006 44.078  -55.782  1.00 73.63  ? 1399 ARG D O   1 
ATOM   6942 C CB  . ARG F 3 55  ? -38.622 46.125  -53.615  1.00 89.45  ? 1399 ARG D CB  1 
ATOM   6943 C CG  . ARG F 3 55  ? -39.977 46.651  -53.180  1.00 92.44  ? 1399 ARG D CG  1 
ATOM   6944 C CD  . ARG F 3 55  ? -39.992 48.171  -53.193  1.00 90.39  ? 1399 ARG D CD  1 
ATOM   6945 N NE  . ARG F 3 55  ? -41.198 48.714  -52.579  1.00 123.36 ? 1399 ARG D NE  1 
ATOM   6946 C CZ  . ARG F 3 55  ? -42.329 48.950  -53.230  1.00 121.75 ? 1399 ARG D CZ  1 
ATOM   6947 N NH1 . ARG F 3 55  ? -42.449 48.696  -54.523  1.00 80.24  ? 1399 ARG D NH1 1 
ATOM   6948 N NH2 . ARG F 3 55  ? -43.367 49.453  -52.566  1.00 118.84 ? 1399 ARG D NH2 1 
ATOM   6949 N N   . ALA F 3 56  ? -37.851 44.536  -56.252  1.00 88.35  ? 1400 ALA D N   1 
ATOM   6950 C CA  . ALA F 3 56  ? -38.040 44.356  -57.688  1.00 89.63  ? 1400 ALA D CA  1 
ATOM   6951 C C   . ALA F 3 56  ? -38.289 42.894  -58.038  1.00 80.59  ? 1400 ALA D C   1 
ATOM   6952 O O   . ALA F 3 56  ? -39.110 42.592  -58.912  1.00 83.19  ? 1400 ALA D O   1 
ATOM   6953 C CB  . ALA F 3 56  ? -36.825 44.890  -58.446  1.00 85.71  ? 1400 ALA D CB  1 
ATOM   6954 N N   . VAL F 3 57  ? -37.588 41.973  -57.375  1.00 69.04  ? 1401 VAL D N   1 
ATOM   6955 C CA  . VAL F 3 57  ? -37.777 40.556  -57.667  1.00 62.59  ? 1401 VAL D CA  1 
ATOM   6956 C C   . VAL F 3 57  ? -39.131 40.080  -57.151  1.00 62.27  ? 1401 VAL D C   1 
ATOM   6957 O O   . VAL F 3 57  ? -39.839 39.329  -57.831  1.00 66.88  ? 1401 VAL D O   1 
ATOM   6958 C CB  . VAL F 3 57  ? -36.617 39.729  -57.079  1.00 59.80  ? 1401 VAL D CB  1 
ATOM   6959 C CG1 . VAL F 3 57  ? -36.939 38.243  -57.120  1.00 58.71  ? 1401 VAL D CG1 1 
ATOM   6960 C CG2 . VAL F 3 57  ? -35.325 40.015  -57.832  1.00 54.14  ? 1401 VAL D CG2 1 
ATOM   6961 N N   . GLN F 3 58  ? -39.528 40.532  -55.959  1.00 72.01  ? 1402 GLN D N   1 
ATOM   6962 C CA  . GLN F 3 58  ? -40.754 40.027  -55.345  1.00 82.00  ? 1402 GLN D CA  1 
ATOM   6963 C C   . GLN F 3 58  ? -41.999 40.442  -56.120  1.00 75.32  ? 1402 GLN D C   1 
ATOM   6964 O O   . GLN F 3 58  ? -43.005 39.723  -56.101  1.00 76.72  ? 1402 GLN D O   1 
ATOM   6965 C CB  . GLN F 3 58  ? -40.847 40.501  -53.895  1.00 83.78  ? 1402 GLN D CB  1 
ATOM   6966 C CG  . GLN F 3 58  ? -41.480 39.489  -52.957  1.00 72.80  ? 1402 GLN D CG  1 
ATOM   6967 C CD  . GLN F 3 58  ? -42.064 40.134  -51.718  1.00 96.24  ? 1402 GLN D CD  1 
ATOM   6968 O OE1 . GLN F 3 58  ? -41.916 41.336  -51.502  1.00 113.72 ? 1402 GLN D OE1 1 
ATOM   6969 N NE2 . GLN F 3 58  ? -42.733 39.335  -50.894  1.00 107.89 ? 1402 GLN D NE2 1 
ATOM   6970 N N   . GLU F 3 59  ? -41.961 41.590  -56.798  1.00 72.40  ? 1403 GLU D N   1 
ATOM   6971 C CA  . GLU F 3 59  ? -43.084 41.998  -57.633  1.00 76.17  ? 1403 GLU D CA  1 
ATOM   6972 C C   . GLU F 3 59  ? -43.037 41.363  -59.015  1.00 82.13  ? 1403 GLU D C   1 
ATOM   6973 O O   . GLU F 3 59  ? -44.058 41.349  -59.712  1.00 78.45  ? 1403 GLU D O   1 
ATOM   6974 C CB  . GLU F 3 59  ? -43.111 43.522  -57.785  1.00 92.84  ? 1403 GLU D CB  1 
ATOM   6975 C CG  . GLU F 3 59  ? -41.774 44.109  -58.214  1.00 101.13 ? 1403 GLU D CG  1 
ATOM   6976 C CD  . GLU F 3 59  ? -41.861 45.561  -58.643  1.00 100.64 ? 1403 GLU D CD  1 
ATOM   6977 O OE1 . GLU F 3 59  ? -41.883 46.442  -57.758  1.00 79.94  ? 1403 GLU D OE1 1 
ATOM   6978 O OE2 . GLU F 3 59  ? -41.888 45.820  -59.866  1.00 98.28  ? 1403 GLU D OE2 1 
ATOM   6979 N N   . LEU F 3 60  ? -41.882 40.832  -59.418  1.00 77.16  ? 1404 LEU D N   1 
ATOM   6980 C CA  . LEU F 3 60  ? -41.666 40.385  -60.783  1.00 70.49  ? 1404 LEU D CA  1 
ATOM   6981 C C   . LEU F 3 60  ? -41.347 38.902  -60.915  1.00 74.83  ? 1404 LEU D C   1 
ATOM   6982 O O   . LEU F 3 60  ? -41.350 38.393  -62.041  1.00 74.63  ? 1404 LEU D O   1 
ATOM   6983 C CB  . LEU F 3 60  ? -40.527 41.195  -61.427  1.00 61.37  ? 1404 LEU D CB  1 
ATOM   6984 C CG  . LEU F 3 60  ? -40.677 41.608  -62.890  1.00 63.80  ? 1404 LEU D CG  1 
ATOM   6985 C CD1 . LEU F 3 60  ? -42.110 42.022  -63.189  1.00 67.06  ? 1404 LEU D CD1 1 
ATOM   6986 C CD2 . LEU F 3 60  ? -39.711 42.735  -63.215  1.00 62.39  ? 1404 LEU D CD2 1 
ATOM   6987 N N   . VAL F 3 61  ? -41.074 38.193  -59.817  1.00 80.37  ? 1405 VAL D N   1 
ATOM   6988 C CA  . VAL F 3 61  ? -40.681 36.791  -59.935  1.00 59.13  ? 1405 VAL D CA  1 
ATOM   6989 C C   . VAL F 3 61  ? -41.872 35.925  -60.325  1.00 57.29  ? 1405 VAL D C   1 
ATOM   6990 O O   . VAL F 3 61  ? -41.738 34.995  -61.127  1.00 54.03  ? 1405 VAL D O   1 
ATOM   6991 C CB  . VAL F 3 61  ? -40.010 36.297  -58.636  1.00 52.84  ? 1405 VAL D CB  1 
ATOM   6992 C CG1 . VAL F 3 61  ? -41.040 35.959  -57.561  1.00 57.51  ? 1405 VAL D CG1 1 
ATOM   6993 C CG2 . VAL F 3 61  ? -39.131 35.090  -58.921  1.00 48.63  ? 1405 VAL D CG2 1 
ATOM   6994 N N   . HIS F 3 62  ? -43.058 36.222  -59.790  1.00 57.69  ? 1406 HIS D N   1 
ATOM   6995 C CA  . HIS F 3 62  ? -44.194 35.339  -60.047  1.00 63.49  ? 1406 HIS D CA  1 
ATOM   6996 C C   . HIS F 3 62  ? -44.706 35.451  -61.476  1.00 64.41  ? 1406 HIS D C   1 
ATOM   6997 O O   . HIS F 3 62  ? -44.753 34.424  -62.172  1.00 78.24  ? 1406 HIS D O   1 
ATOM   6998 C CB  . HIS F 3 62  ? -45.286 35.584  -59.004  1.00 76.55  ? 1406 HIS D CB  1 
ATOM   6999 C CG  . HIS F 3 62  ? -45.335 34.525  -57.944  1.00 84.47  ? 1406 HIS D CG  1 
ATOM   7000 N ND1 . HIS F 3 62  ? -45.414 33.180  -58.239  1.00 78.33  ? 1406 HIS D ND1 1 
ATOM   7001 C CD2 . HIS F 3 62  ? -45.283 34.609  -56.594  1.00 78.86  ? 1406 HIS D CD2 1 
ATOM   7002 C CE1 . HIS F 3 62  ? -45.428 32.483  -57.117  1.00 81.90  ? 1406 HIS D CE1 1 
ATOM   7003 N NE2 . HIS F 3 62  ? -45.349 33.327  -56.104  1.00 77.19  ? 1406 HIS D NE2 1 
ATOM   7004 N N   . PRO F 3 63  ? -45.061 36.629  -61.996  1.00 67.05  ? 1407 PRO D N   1 
ATOM   7005 C CA  . PRO F 3 63  ? -45.641 36.659  -63.353  1.00 62.38  ? 1407 PRO D CA  1 
ATOM   7006 C C   . PRO F 3 63  ? -44.647 36.302  -64.444  1.00 64.63  ? 1407 PRO D C   1 
ATOM   7007 O O   . PRO F 3 63  ? -45.060 35.835  -65.512  1.00 57.22  ? 1407 PRO D O   1 
ATOM   7008 C CB  . PRO F 3 63  ? -46.147 38.113  -63.499  1.00 55.59  ? 1407 PRO D CB  1 
ATOM   7009 C CG  . PRO F 3 63  ? -45.555 38.887  -62.349  1.00 80.47  ? 1407 PRO D CG  1 
ATOM   7010 C CD  . PRO F 3 63  ? -44.662 37.981  -61.557  1.00 70.48  ? 1407 PRO D CD  1 
ATOM   7011 N N   . VAL F 3 64  ? -43.349 36.480  -64.199  1.00 60.32  ? 1408 VAL D N   1 
ATOM   7012 C CA  . VAL F 3 64  ? -42.348 36.105  -65.191  1.00 48.86  ? 1408 VAL D CA  1 
ATOM   7013 C C   . VAL F 3 64  ? -42.160 34.592  -65.221  1.00 52.42  ? 1408 VAL D C   1 
ATOM   7014 O O   . VAL F 3 64  ? -42.043 33.992  -66.295  1.00 61.55  ? 1408 VAL D O   1 
ATOM   7015 C CB  . VAL F 3 64  ? -41.028 36.846  -64.904  1.00 44.25  ? 1408 VAL D CB  1 
ATOM   7016 C CG1 . VAL F 3 64  ? -39.838 36.055  -65.423  1.00 56.43  ? 1408 VAL D CG1 1 
ATOM   7017 C CG2 . VAL F 3 64  ? -41.061 38.238  -65.514  1.00 45.69  ? 1408 VAL D CG2 1 
ATOM   7018 N N   . VAL F 3 65  ? -42.138 33.951  -64.049  1.00 57.65  ? 1409 VAL D N   1 
ATOM   7019 C CA  . VAL F 3 65  ? -41.963 32.502  -64.001  1.00 62.92  ? 1409 VAL D CA  1 
ATOM   7020 C C   . VAL F 3 65  ? -43.121 31.801  -64.704  1.00 68.83  ? 1409 VAL D C   1 
ATOM   7021 O O   . VAL F 3 65  ? -42.917 30.831  -65.445  1.00 72.49  ? 1409 VAL D O   1 
ATOM   7022 C CB  . VAL F 3 65  ? -41.799 32.026  -62.544  1.00 56.77  ? 1409 VAL D CB  1 
ATOM   7023 C CG1 . VAL F 3 65  ? -42.070 30.531  -62.433  1.00 65.44  ? 1409 VAL D CG1 1 
ATOM   7024 C CG2 . VAL F 3 65  ? -40.396 32.338  -62.039  1.00 50.12  ? 1409 VAL D CG2 1 
ATOM   7025 N N   . ASP F 3 66  ? -44.352 32.291  -64.508  1.00 60.31  ? 1410 ASP D N   1 
ATOM   7026 C CA  . ASP F 3 66  ? -45.492 31.653  -65.162  1.00 54.16  ? 1410 ASP D CA  1 
ATOM   7027 C C   . ASP F 3 66  ? -45.432 31.792  -66.677  1.00 51.56  ? 1410 ASP D C   1 
ATOM   7028 O O   . ASP F 3 66  ? -45.856 30.878  -67.394  1.00 57.07  ? 1410 ASP D O   1 
ATOM   7029 C CB  . ASP F 3 66  ? -46.820 32.215  -64.649  1.00 73.54  ? 1410 ASP D CB  1 
ATOM   7030 C CG  . ASP F 3 66  ? -46.926 32.195  -63.137  1.00 95.49  ? 1410 ASP D CG  1 
ATOM   7031 O OD1 . ASP F 3 66  ? -46.894 31.087  -62.559  1.00 85.26  ? 1410 ASP D OD1 1 
ATOM   7032 O OD2 . ASP F 3 66  ? -47.114 33.274  -62.533  1.00 103.11 ? 1410 ASP D OD2 1 
ATOM   7033 N N   . ARG F 3 67  ? -44.925 32.918  -67.188  1.00 51.24  ? 1411 ARG D N   1 
ATOM   7034 C CA  . ARG F 3 67  ? -44.878 33.093  -68.636  1.00 49.85  ? 1411 ARG D CA  1 
ATOM   7035 C C   . ARG F 3 67  ? -43.749 32.284  -69.264  1.00 52.34  ? 1411 ARG D C   1 
ATOM   7036 O O   . ARG F 3 67  ? -43.941 31.672  -70.320  1.00 67.25  ? 1411 ARG D O   1 
ATOM   7037 C CB  . ARG F 3 67  ? -44.739 34.571  -68.999  1.00 57.20  ? 1411 ARG D CB  1 
ATOM   7038 C CG  . ARG F 3 67  ? -45.712 35.015  -70.089  1.00 72.39  ? 1411 ARG D CG  1 
ATOM   7039 C CD  . ARG F 3 67  ? -45.327 36.355  -70.705  1.00 77.55  ? 1411 ARG D CD  1 
ATOM   7040 N NE  . ARG F 3 67  ? -45.861 36.500  -72.056  1.00 88.46  ? 1411 ARG D NE  1 
ATOM   7041 C CZ  . ARG F 3 67  ? -45.210 37.057  -73.070  1.00 88.21  ? 1411 ARG D CZ  1 
ATOM   7042 N NH1 . ARG F 3 67  ? -43.990 37.550  -72.923  1.00 82.31  ? 1411 ARG D NH1 1 
ATOM   7043 N NH2 . ARG F 3 67  ? -45.798 37.123  -74.261  1.00 72.90  ? 1411 ARG D NH2 1 
ATOM   7044 N N   . SER F 3 68  ? -42.568 32.273  -68.639  1.00 54.96  ? 1412 SER D N   1 
ATOM   7045 C CA  . SER F 3 68  ? -41.466 31.469  -69.159  1.00 57.37  ? 1412 SER D CA  1 
ATOM   7046 C C   . SER F 3 68  ? -41.842 29.997  -69.236  1.00 56.57  ? 1412 SER D C   1 
ATOM   7047 O O   . SER F 3 68  ? -41.412 29.292  -70.159  1.00 63.11  ? 1412 SER D O   1 
ATOM   7048 C CB  . SER F 3 68  ? -40.218 31.650  -68.296  1.00 59.14  ? 1412 SER D CB  1 
ATOM   7049 O OG  . SER F 3 68  ? -40.120 32.974  -67.805  1.00 65.27  ? 1412 SER D OG  1 
ATOM   7050 N N   . ILE F 3 69  ? -42.644 29.515  -68.284  1.00 58.54  ? 1413 ILE D N   1 
ATOM   7051 C CA  . ILE F 3 69  ? -43.129 28.142  -68.355  1.00 55.36  ? 1413 ILE D CA  1 
ATOM   7052 C C   . ILE F 3 69  ? -44.028 27.962  -69.572  1.00 51.76  ? 1413 ILE D C   1 
ATOM   7053 O O   . ILE F 3 69  ? -43.885 26.992  -70.322  1.00 70.57  ? 1413 ILE D O   1 
ATOM   7054 C CB  . ILE F 3 69  ? -43.848 27.752  -67.047  1.00 62.43  ? 1413 ILE D CB  1 
ATOM   7055 C CG1 . ILE F 3 69  ? -42.902 27.003  -66.103  1.00 45.59  ? 1413 ILE D CG1 1 
ATOM   7056 C CG2 . ILE F 3 69  ? -45.078 26.896  -67.325  1.00 54.60  ? 1413 ILE D CG2 1 
ATOM   7057 C CD1 . ILE F 3 69  ? -41.700 27.802  -65.661  1.00 51.50  ? 1413 ILE D CD1 1 
ATOM   7058 N N   . LYS F 3 70  ? -44.934 28.915  -69.816  1.00 50.10  ? 1414 LYS D N   1 
ATOM   7059 C CA  . LYS F 3 70  ? -45.933 28.745  -70.870  1.00 56.84  ? 1414 LYS D CA  1 
ATOM   7060 C C   . LYS F 3 70  ? -45.282 28.610  -72.245  1.00 56.72  ? 1414 LYS D C   1 
ATOM   7061 O O   . LYS F 3 70  ? -45.653 27.734  -73.037  1.00 47.66  ? 1414 LYS D O   1 
ATOM   7062 C CB  . LYS F 3 70  ? -46.918 29.917  -70.851  1.00 44.09  ? 1414 LYS D CB  1 
ATOM   7063 C CG  . LYS F 3 70  ? -47.847 29.978  -72.058  1.00 54.96  ? 1414 LYS D CG  1 
ATOM   7064 C CD  . LYS F 3 70  ? -49.099 30.790  -71.763  1.00 48.07  ? 1414 LYS D CD  1 
ATOM   7065 C CE  . LYS F 3 70  ? -49.314 31.876  -72.810  1.00 54.57  ? 1414 LYS D CE  1 
ATOM   7066 N NZ  . LYS F 3 70  ? -49.947 33.096  -72.231  1.00 62.70  ? 1414 LYS D NZ  1 
ATOM   7067 N N   . ILE F 3 71  ? -44.305 29.468  -72.546  1.00 51.63  ? 1415 ILE D N   1 
ATOM   7068 C CA  . ILE F 3 71  ? -43.685 29.449  -73.869  1.00 49.79  ? 1415 ILE D CA  1 
ATOM   7069 C C   . ILE F 3 71  ? -42.847 28.190  -74.051  1.00 51.14  ? 1415 ILE D C   1 
ATOM   7070 O O   . ILE F 3 71  ? -42.929 27.512  -75.082  1.00 52.64  ? 1415 ILE D O   1 
ATOM   7071 C CB  . ILE F 3 71  ? -42.846 30.720  -74.092  1.00 41.35  ? 1415 ILE D CB  1 
ATOM   7072 C CG1 . ILE F 3 71  ? -43.526 31.934  -73.454  1.00 43.59  ? 1415 ILE D CG1 1 
ATOM   7073 C CG2 . ILE F 3 71  ? -42.609 30.950  -75.577  1.00 50.52  ? 1415 ILE D CG2 1 
ATOM   7074 C CD1 . ILE F 3 71  ? -44.689 32.487  -74.254  1.00 52.95  ? 1415 ILE D CD1 1 
ATOM   7075 N N   . ALA F 3 72  ? -42.033 27.854  -73.048  1.00 44.51  ? 1416 ALA D N   1 
ATOM   7076 C CA  . ALA F 3 72  ? -41.096 26.745  -73.189  1.00 46.60  ? 1416 ALA D CA  1 
ATOM   7077 C C   . ALA F 3 72  ? -41.777 25.386  -73.082  1.00 52.39  ? 1416 ALA D C   1 
ATOM   7078 O O   . ALA F 3 72  ? -41.282 24.407  -73.652  1.00 56.44  ? 1416 ALA D O   1 
ATOM   7079 C CB  . ALA F 3 72  ? -39.991 26.861  -72.139  1.00 43.98  ? 1416 ALA D CB  1 
ATOM   7080 N N   . MET F 3 73  ? -42.910 25.309  -72.379  1.00 51.24  ? 1417 MET D N   1 
ATOM   7081 C CA  . MET F 3 73  ? -43.511 24.017  -72.060  1.00 41.75  ? 1417 MET D CA  1 
ATOM   7082 C C   . MET F 3 73  ? -43.985 23.291  -73.313  1.00 48.85  ? 1417 MET D C   1 
ATOM   7083 O O   . MET F 3 73  ? -43.552 22.169  -73.598  1.00 54.61  ? 1417 MET D O   1 
ATOM   7084 C CB  . MET F 3 73  ? -44.674 24.207  -71.089  1.00 49.76  ? 1417 MET D CB  1 
ATOM   7085 C CG  . MET F 3 73  ? -44.304 23.999  -69.634  1.00 66.06  ? 1417 MET D CG  1 
ATOM   7086 S SD  . MET F 3 73  ? -44.395 22.256  -69.231  1.00 84.05  ? 1417 MET D SD  1 
ATOM   7087 C CE  . MET F 3 73  ? -45.786 21.841  -70.264  1.00 62.62  ? 1417 MET D CE  1 
ATOM   7088 N N   . THR F 3 74  ? -44.901 23.909  -74.064  1.00 51.31  ? 1418 THR D N   1 
ATOM   7089 C CA  . THR F 3 74  ? -45.443 23.248  -75.245  1.00 45.00  ? 1418 THR D CA  1 
ATOM   7090 C C   . THR F 3 74  ? -44.356 22.947  -76.265  1.00 45.87  ? 1418 THR D C   1 
ATOM   7091 O O   . THR F 3 74  ? -44.421 21.925  -76.956  1.00 54.95  ? 1418 THR D O   1 
ATOM   7092 C CB  . THR F 3 74  ? -46.539 24.103  -75.881  1.00 55.74  ? 1418 THR D CB  1 
ATOM   7093 O OG1 . THR F 3 74  ? -47.340 24.700  -74.853  1.00 73.94  ? 1418 THR D OG1 1 
ATOM   7094 C CG2 . THR F 3 74  ? -47.424 23.248  -76.775  1.00 60.72  ? 1418 THR D CG2 1 
ATOM   7095 N N   . THR F 3 75  ? -43.343 23.809  -76.364  1.00 48.79  ? 1419 THR D N   1 
ATOM   7096 C CA  . THR F 3 75  ? -42.271 23.576  -77.326  1.00 42.86  ? 1419 THR D CA  1 
ATOM   7097 C C   . THR F 3 75  ? -41.458 22.340  -76.955  1.00 39.64  ? 1419 THR D C   1 
ATOM   7098 O O   . THR F 3 75  ? -41.283 21.433  -77.776  1.00 37.74  ? 1419 THR D O   1 
ATOM   7099 C CB  . THR F 3 75  ? -41.374 24.810  -77.418  1.00 42.82  ? 1419 THR D CB  1 
ATOM   7100 O OG1 . THR F 3 75  ? -42.050 25.836  -78.154  1.00 41.66  ? 1419 THR D OG1 1 
ATOM   7101 C CG2 . THR F 3 75  ? -40.074 24.471  -78.122  1.00 32.02  ? 1419 THR D CG2 1 
ATOM   7102 N N   . CYS F 3 76  ? -40.965 22.282  -75.713  1.00 38.18  ? 1420 CYS D N   1 
ATOM   7103 C CA  . CYS F 3 76  ? -40.111 21.171  -75.300  1.00 43.74  ? 1420 CYS D CA  1 
ATOM   7104 C C   . CYS F 3 76  ? -40.826 19.834  -75.431  1.00 45.09  ? 1420 CYS D C   1 
ATOM   7105 O O   . CYS F 3 76  ? -40.232 18.845  -75.877  1.00 41.66  ? 1420 CYS D O   1 
ATOM   7106 C CB  . CYS F 3 76  ? -39.641 21.372  -73.860  1.00 34.99  ? 1420 CYS D CB  1 
ATOM   7107 S SG  . CYS F 3 76  ? -38.542 22.776  -73.621  1.00 60.48  ? 1420 CYS D SG  1 
ATOM   7108 N N   . GLU F 3 77  ? -42.103 19.783  -75.044  1.00 44.96  ? 1421 GLU D N   1 
ATOM   7109 C CA  . GLU F 3 77  ? -42.828 18.517  -75.051  1.00 41.10  ? 1421 GLU D CA  1 
ATOM   7110 C C   . GLU F 3 77  ? -42.905 17.931  -76.456  1.00 43.94  ? 1421 GLU D C   1 
ATOM   7111 O O   . GLU F 3 77  ? -42.584 16.756  -76.667  1.00 47.96  ? 1421 GLU D O   1 
ATOM   7112 C CB  . GLU F 3 77  ? -44.227 18.709  -74.466  1.00 43.40  ? 1421 GLU D CB  1 
ATOM   7113 C CG  . GLU F 3 77  ? -45.194 17.586  -74.804  1.00 58.28  ? 1421 GLU D CG  1 
ATOM   7114 C CD  . GLU F 3 77  ? -46.606 17.867  -74.327  1.00 87.10  ? 1421 GLU D CD  1 
ATOM   7115 O OE1 . GLU F 3 77  ? -46.943 19.054  -74.127  1.00 94.89  ? 1421 GLU D OE1 1 
ATOM   7116 O OE2 . GLU F 3 77  ? -47.381 16.901  -74.156  1.00 94.28  ? 1421 GLU D OE2 1 
ATOM   7117 N N   . GLN F 3 78  ? -43.313 18.740  -77.438  1.00 35.00  ? 1422 GLN D N   1 
ATOM   7118 C CA  . GLN F 3 78  ? -43.462 18.219  -78.794  1.00 33.92  ? 1422 GLN D CA  1 
ATOM   7119 C C   . GLN F 3 78  ? -42.118 17.859  -79.416  1.00 38.51  ? 1422 GLN D C   1 
ATOM   7120 O O   . GLN F 3 78  ? -42.050 16.951  -80.253  1.00 38.81  ? 1422 GLN D O   1 
ATOM   7121 C CB  . GLN F 3 78  ? -44.196 19.229  -79.676  1.00 40.24  ? 1422 GLN D CB  1 
ATOM   7122 C CG  . GLN F 3 78  ? -45.358 19.916  -78.991  1.00 38.26  ? 1422 GLN D CG  1 
ATOM   7123 C CD  . GLN F 3 78  ? -46.698 19.501  -79.551  1.00 47.42  ? 1422 GLN D CD  1 
ATOM   7124 O OE1 . GLN F 3 78  ? -46.830 19.240  -80.747  1.00 58.46  ? 1422 GLN D OE1 1 
ATOM   7125 N NE2 . GLN F 3 78  ? -47.706 19.441  -78.688  1.00 57.32  ? 1422 GLN D NE2 1 
ATOM   7126 N N   . ILE F 3 79  ? -41.045 18.548  -79.027  1.00 35.52  ? 1423 ILE D N   1 
ATOM   7127 C CA  . ILE F 3 79  ? -39.734 18.246  -79.591  1.00 31.11  ? 1423 ILE D CA  1 
ATOM   7128 C C   . ILE F 3 79  ? -39.128 17.017  -78.924  1.00 35.22  ? 1423 ILE D C   1 
ATOM   7129 O O   . ILE F 3 79  ? -38.573 16.143  -79.599  1.00 38.53  ? 1423 ILE D O   1 
ATOM   7130 C CB  . ILE F 3 79  ? -38.810 19.472  -79.475  1.00 30.71  ? 1423 ILE D CB  1 
ATOM   7131 C CG1 . ILE F 3 79  ? -39.414 20.665  -80.219  1.00 19.09  ? 1423 ILE D CG1 1 
ATOM   7132 C CG2 . ILE F 3 79  ? -37.424 19.148  -80.010  1.00 36.63  ? 1423 ILE D CG2 1 
ATOM   7133 C CD1 . ILE F 3 79  ? -39.534 20.461  -81.708  1.00 23.18  ? 1423 ILE D CD1 1 
ATOM   7134 N N   . VAL F 3 80  ? -39.227 16.925  -77.596  1.00 32.62  ? 1424 VAL D N   1 
ATOM   7135 C CA  . VAL F 3 80  ? -38.684 15.764  -76.896  1.00 31.51  ? 1424 VAL D CA  1 
ATOM   7136 C C   . VAL F 3 80  ? -39.480 14.509  -77.239  1.00 41.69  ? 1424 VAL D C   1 
ATOM   7137 O O   . VAL F 3 80  ? -38.908 13.428  -77.432  1.00 45.24  ? 1424 VAL D O   1 
ATOM   7138 C CB  . VAL F 3 80  ? -38.652 16.026  -75.381  1.00 20.31  ? 1424 VAL D CB  1 
ATOM   7139 C CG1 . VAL F 3 80  ? -38.291 14.757  -74.628  1.00 29.40  ? 1424 VAL D CG1 1 
ATOM   7140 C CG2 . VAL F 3 80  ? -37.660 17.132  -75.065  1.00 35.12  ? 1424 VAL D CG2 1 
ATOM   7141 N N   . ARG F 3 81  ? -40.807 14.629  -77.332  1.00 36.59  ? 1425 ARG D N   1 
ATOM   7142 C CA  . ARG F 3 81  ? -41.629 13.481  -77.702  1.00 23.57  ? 1425 ARG D CA  1 
ATOM   7143 C C   . ARG F 3 81  ? -41.321 13.018  -79.121  1.00 36.84  ? 1425 ARG D C   1 
ATOM   7144 O O   . ARG F 3 81  ? -41.285 11.811  -79.394  1.00 47.37  ? 1425 ARG D O   1 
ATOM   7145 C CB  . ARG F 3 81  ? -43.110 13.829  -77.552  1.00 33.52  ? 1425 ARG D CB  1 
ATOM   7146 C CG  . ARG F 3 81  ? -44.037 13.148  -78.548  1.00 43.72  ? 1425 ARG D CG  1 
ATOM   7147 C CD  . ARG F 3 81  ? -45.442 13.733  -78.474  1.00 60.06  ? 1425 ARG D CD  1 
ATOM   7148 N NE  . ARG F 3 81  ? -45.878 13.931  -77.096  1.00 79.59  ? 1425 ARG D NE  1 
ATOM   7149 C CZ  . ARG F 3 81  ? -46.987 14.567  -76.743  1.00 76.20  ? 1425 ARG D CZ  1 
ATOM   7150 N NH1 . ARG F 3 81  ? -47.805 15.085  -77.646  1.00 63.84  ? 1425 ARG D NH1 1 
ATOM   7151 N NH2 . ARG F 3 81  ? -47.285 14.684  -75.452  1.00 70.38  ? 1425 ARG D NH2 1 
ATOM   7152 N N   . LYS F 3 82  ? -41.087 13.961  -80.037  1.00 43.18  ? 1426 LYS D N   1 
ATOM   7153 C CA  . LYS F 3 82  ? -40.775 13.592  -81.415  1.00 28.29  ? 1426 LYS D CA  1 
ATOM   7154 C C   . LYS F 3 82  ? -39.421 12.900  -81.505  1.00 31.66  ? 1426 LYS D C   1 
ATOM   7155 O O   . LYS F 3 82  ? -39.286 11.862  -82.163  1.00 52.07  ? 1426 LYS D O   1 
ATOM   7156 C CB  . LYS F 3 82  ? -40.804 14.830  -82.312  1.00 27.85  ? 1426 LYS D CB  1 
ATOM   7157 C CG  . LYS F 3 82  ? -39.913 14.720  -83.543  1.00 42.22  ? 1426 LYS D CG  1 
ATOM   7158 C CD  . LYS F 3 82  ? -39.804 16.045  -84.283  1.00 35.41  ? 1426 LYS D CD  1 
ATOM   7159 C CE  . LYS F 3 82  ? -38.619 16.857  -83.792  1.00 38.88  ? 1426 LYS D CE  1 
ATOM   7160 N NZ  . LYS F 3 82  ? -37.365 16.523  -84.528  1.00 38.91  ? 1426 LYS D NZ  1 
ATOM   7161 N N   . ASP F 3 83  ? -38.405 13.462  -80.845  1.00 34.80  ? 1427 ASP D N   1 
ATOM   7162 C CA  . ASP F 3 83  ? -37.065 12.884  -80.899  1.00 42.32  ? 1427 ASP D CA  1 
ATOM   7163 C C   . ASP F 3 83  ? -37.028 11.512  -80.238  1.00 44.47  ? 1427 ASP D C   1 
ATOM   7164 O O   . ASP F 3 83  ? -36.544 10.538  -80.828  1.00 51.07  ? 1427 ASP D O   1 
ATOM   7165 C CB  . ASP F 3 83  ? -36.063 13.827  -80.234  1.00 43.66  ? 1427 ASP D CB  1 
ATOM   7166 C CG  . ASP F 3 83  ? -35.860 15.108  -81.016  1.00 53.14  ? 1427 ASP D CG  1 
ATOM   7167 O OD1 . ASP F 3 83  ? -35.080 15.967  -80.555  1.00 52.35  ? 1427 ASP D OD1 1 
ATOM   7168 O OD2 . ASP F 3 83  ? -36.473 15.253  -82.095  1.00 53.49  ? 1427 ASP D OD2 1 
ATOM   7169 N N   . PHE F 3 84  ? -37.535 11.417  -79.008  1.00 28.28  ? 1428 PHE D N   1 
ATOM   7170 C CA  . PHE F 3 84  ? -37.528 10.170  -78.255  1.00 33.30  ? 1428 PHE D CA  1 
ATOM   7171 C C   . PHE F 3 84  ? -38.751 9.306   -78.535  1.00 44.17  ? 1428 PHE D C   1 
ATOM   7172 O O   . PHE F 3 84  ? -39.191 8.555   -77.653  1.00 45.65  ? 1428 PHE D O   1 
ATOM   7173 C CB  . PHE F 3 84  ? -37.420 10.467  -76.761  1.00 33.80  ? 1428 PHE D CB  1 
ATOM   7174 C CG  . PHE F 3 84  ? -36.090 11.015  -76.348  1.00 34.48  ? 1428 PHE D CG  1 
ATOM   7175 C CD1 . PHE F 3 84  ? -35.828 12.372  -76.438  1.00 32.93  ? 1428 PHE D CD1 1 
ATOM   7176 C CD2 . PHE F 3 84  ? -35.104 10.175  -75.860  1.00 47.68  ? 1428 PHE D CD2 1 
ATOM   7177 C CE1 . PHE F 3 84  ? -34.604 12.880  -76.060  1.00 35.31  ? 1428 PHE D CE1 1 
ATOM   7178 C CE2 . PHE F 3 84  ? -33.876 10.678  -75.477  1.00 64.83  ? 1428 PHE D CE2 1 
ATOM   7179 C CZ  . PHE F 3 84  ? -33.626 12.031  -75.579  1.00 51.06  ? 1428 PHE D CZ  1 
ATOM   7180 N N   . ALA F 3 85  ? -39.315 9.392   -79.742  1.00 44.23  ? 1429 ALA D N   1 
ATOM   7181 C CA  . ALA F 3 85  ? -40.505 8.610   -80.057  1.00 37.26  ? 1429 ALA D CA  1 
ATOM   7182 C C   . ALA F 3 85  ? -40.177 7.128   -80.182  1.00 47.77  ? 1429 ALA D C   1 
ATOM   7183 O O   . ALA F 3 85  ? -40.985 6.273   -79.800  1.00 47.76  ? 1429 ALA D O   1 
ATOM   7184 C CB  . ALA F 3 85  ? -41.149 9.132   -81.341  1.00 28.99  ? 1429 ALA D CB  1 
ATOM   7185 N N   . LEU F 3 86  ? -38.997 6.802   -80.710  1.00 55.89  ? 1430 LEU D N   1 
ATOM   7186 C CA  . LEU F 3 86  ? -38.604 5.411   -80.887  1.00 43.99  ? 1430 LEU D CA  1 
ATOM   7187 C C   . LEU F 3 86  ? -37.857 4.843   -79.688  1.00 54.45  ? 1430 LEU D C   1 
ATOM   7188 O O   . LEU F 3 86  ? -37.807 3.617   -79.535  1.00 58.32  ? 1430 LEU D O   1 
ATOM   7189 C CB  . LEU F 3 86  ? -37.746 5.262   -82.145  1.00 47.94  ? 1430 LEU D CB  1 
ATOM   7190 C CG  . LEU F 3 86  ? -38.519 5.206   -83.464  1.00 41.98  ? 1430 LEU D CG  1 
ATOM   7191 C CD1 . LEU F 3 86  ? -37.723 4.453   -84.515  1.00 55.96  ? 1430 LEU D CD1 1 
ATOM   7192 C CD2 . LEU F 3 86  ? -39.890 4.571   -83.269  1.00 39.96  ? 1430 LEU D CD2 1 
ATOM   7193 N N   . ASP F 3 87  ? -37.276 5.691   -78.842  1.00 70.03  ? 1431 ASP D N   1 
ATOM   7194 C CA  . ASP F 3 87  ? -36.668 5.208   -77.609  1.00 71.31  ? 1431 ASP D CA  1 
ATOM   7195 C C   . ASP F 3 87  ? -37.745 4.715   -76.653  1.00 73.56  ? 1431 ASP D C   1 
ATOM   7196 O O   . ASP F 3 87  ? -38.782 5.360   -76.471  1.00 77.14  ? 1431 ASP D O   1 
ATOM   7197 C CB  . ASP F 3 87  ? -35.837 6.309   -76.947  1.00 59.77  ? 1431 ASP D CB  1 
ATOM   7198 C CG  . ASP F 3 87  ? -34.990 5.792   -75.793  1.00 70.15  ? 1431 ASP D CG  1 
ATOM   7199 O OD1 . ASP F 3 87  ? -35.549 5.193   -74.855  1.00 78.90  ? 1431 ASP D OD1 1 
ATOM   7200 O OD2 . ASP F 3 87  ? -33.759 5.979   -75.819  1.00 73.57  ? 1431 ASP D OD2 1 
ATOM   7201 N N   . SER F 3 88  ? -37.491 3.566   -76.031  1.00 64.93  ? 1432 SER D N   1 
ATOM   7202 C CA  . SER F 3 88  ? -38.440 2.957   -75.112  1.00 62.13  ? 1432 SER D CA  1 
ATOM   7203 C C   . SER F 3 88  ? -38.080 3.172   -73.651  1.00 72.76  ? 1432 SER D C   1 
ATOM   7204 O O   . SER F 3 88  ? -38.837 2.749   -72.772  1.00 63.24  ? 1432 SER D O   1 
ATOM   7205 C CB  . SER F 3 88  ? -38.557 1.459   -75.397  1.00 73.30  ? 1432 SER D CB  1 
ATOM   7206 O OG  . SER F 3 88  ? -39.609 1.214   -76.309  1.00 79.15  ? 1432 SER D OG  1 
ATOM   7207 N N   . GLU F 3 89  ? -36.950 3.814   -73.370  1.00 85.02  ? 1433 GLU D N   1 
ATOM   7208 C CA  . GLU F 3 89  ? -36.505 4.074   -72.005  1.00 83.53  ? 1433 GLU D CA  1 
ATOM   7209 C C   . GLU F 3 89  ? -36.942 5.482   -71.611  1.00 83.59  ? 1433 GLU D C   1 
ATOM   7210 O O   . GLU F 3 89  ? -36.401 6.473   -72.112  1.00 79.93  ? 1433 GLU D O   1 
ATOM   7211 C CB  . GLU F 3 89  ? -34.990 3.900   -71.887  1.00 84.09  ? 1433 GLU D CB  1 
ATOM   7212 C CG  . GLU F 3 89  ? -34.404 3.921   -70.462  1.00 102.64 ? 1433 GLU D CG  1 
ATOM   7213 C CD  . GLU F 3 89  ? -35.261 3.243   -69.387  1.00 120.44 ? 1433 GLU D CD  1 
ATOM   7214 O OE1 . GLU F 3 89  ? -35.043 3.548   -68.195  1.00 138.29 ? 1433 GLU D OE1 1 
ATOM   7215 O OE2 . GLU F 3 89  ? -36.110 2.379   -69.703  1.00 118.99 ? 1433 GLU D OE2 1 
ATOM   7216 N N   . GLU F 3 90  ? -37.925 5.560   -70.710  1.00 84.64  ? 1434 GLU D N   1 
ATOM   7217 C CA  . GLU F 3 90  ? -38.488 6.839   -70.296  1.00 79.04  ? 1434 GLU D CA  1 
ATOM   7218 C C   . GLU F 3 90  ? -37.524 7.663   -69.449  1.00 78.03  ? 1434 GLU D C   1 
ATOM   7219 O O   . GLU F 3 90  ? -37.675 8.888   -69.380  1.00 84.82  ? 1434 GLU D O   1 
ATOM   7220 C CB  . GLU F 3 90  ? -39.790 6.609   -69.523  1.00 77.69  ? 1434 GLU D CB  1 
ATOM   7221 C CG  . GLU F 3 90  ? -39.589 6.068   -68.116  1.00 95.52  ? 1434 GLU D CG  1 
ATOM   7222 C CD  . GLU F 3 90  ? -40.028 4.617   -67.972  1.00 100.03 ? 1434 GLU D CD  1 
ATOM   7223 O OE1 . GLU F 3 90  ? -39.923 4.071   -66.847  1.00 101.69 ? 1434 GLU D OE1 1 
ATOM   7224 O OE2 . GLU F 3 90  ? -40.467 4.018   -68.977  1.00 93.64  ? 1434 GLU D OE2 1 
ATOM   7225 N N   . SER F 3 91  ? -36.542 7.030   -68.803  1.00 75.09  ? 1435 SER D N   1 
ATOM   7226 C CA  . SER F 3 91  ? -35.603 7.793   -67.986  1.00 75.69  ? 1435 SER D CA  1 
ATOM   7227 C C   . SER F 3 91  ? -34.695 8.656   -68.852  1.00 68.32  ? 1435 SER D C   1 
ATOM   7228 O O   . SER F 3 91  ? -34.331 9.771   -68.460  1.00 49.51  ? 1435 SER D O   1 
ATOM   7229 C CB  . SER F 3 91  ? -34.775 6.856   -67.107  1.00 70.31  ? 1435 SER D CB  1 
ATOM   7230 O OG  . SER F 3 91  ? -34.319 5.735   -67.839  1.00 74.61  ? 1435 SER D OG  1 
ATOM   7231 N N   . ARG F 3 92  ? -34.318 8.158   -70.033  1.00 68.44  ? 1436 ARG D N   1 
ATOM   7232 C CA  . ARG F 3 92  ? -33.517 8.963   -70.949  1.00 60.92  ? 1436 ARG D CA  1 
ATOM   7233 C C   . ARG F 3 92  ? -34.322 10.134  -71.494  1.00 52.83  ? 1436 ARG D C   1 
ATOM   7234 O O   . ARG F 3 92  ? -33.779 11.227  -71.699  1.00 56.48  ? 1436 ARG D O   1 
ATOM   7235 C CB  . ARG F 3 92  ? -32.990 8.095   -72.092  1.00 76.70  ? 1436 ARG D CB  1 
ATOM   7236 C CG  . ARG F 3 92  ? -31.588 8.462   -72.559  1.00 80.10  ? 1436 ARG D CG  1 
ATOM   7237 C CD  . ARG F 3 92  ? -30.755 7.219   -72.829  1.00 89.37  ? 1436 ARG D CD  1 
ATOM   7238 N NE  . ARG F 3 92  ? -31.358 6.373   -73.852  1.00 89.20  ? 1436 ARG D NE  1 
ATOM   7239 C CZ  . ARG F 3 92  ? -31.788 5.136   -73.643  1.00 96.47  ? 1436 ARG D CZ  1 
ATOM   7240 N NH1 . ARG F 3 92  ? -31.703 4.565   -72.452  1.00 93.53  ? 1436 ARG D NH1 1 
ATOM   7241 N NH2 . ARG F 3 92  ? -32.321 4.455   -74.654  1.00 89.42  ? 1436 ARG D NH2 1 
ATOM   7242 N N   . MET F 3 93  ? -35.618 9.925   -71.737  1.00 44.37  ? 1437 MET D N   1 
ATOM   7243 C CA  . MET F 3 93  ? -36.472 11.024  -72.174  1.00 39.03  ? 1437 MET D CA  1 
ATOM   7244 C C   . MET F 3 93  ? -36.646 12.057  -71.068  1.00 48.05  ? 1437 MET D C   1 
ATOM   7245 O O   . MET F 3 93  ? -36.584 13.265  -71.325  1.00 56.01  ? 1437 MET D O   1 
ATOM   7246 C CB  . MET F 3 93  ? -37.832 10.490  -72.619  1.00 38.15  ? 1437 MET D CB  1 
ATOM   7247 C CG  . MET F 3 93  ? -38.866 11.579  -72.857  1.00 51.96  ? 1437 MET D CG  1 
ATOM   7248 S SD  . MET F 3 93  ? -40.436 10.957  -73.489  1.00 65.63  ? 1437 MET D SD  1 
ATOM   7249 C CE  . MET F 3 93  ? -39.868 9.610   -74.504  1.00 27.55  ? 1437 MET D CE  1 
ATOM   7250 N N   . ARG F 3 94  ? -36.862 11.601  -69.830  1.00 56.98  ? 1438 ARG D N   1 
ATOM   7251 C CA  . ARG F 3 94  ? -37.052 12.527  -68.718  1.00 52.53  ? 1438 ARG D CA  1 
ATOM   7252 C C   . ARG F 3 94  ? -35.813 13.378  -68.478  1.00 56.90  ? 1438 ARG D C   1 
ATOM   7253 O O   . ARG F 3 94  ? -35.929 14.545  -68.085  1.00 66.97  ? 1438 ARG D O   1 
ATOM   7254 C CB  . ARG F 3 94  ? -37.416 11.757  -67.447  1.00 51.20  ? 1438 ARG D CB  1 
ATOM   7255 C CG  . ARG F 3 94  ? -37.880 12.637  -66.291  1.00 57.42  ? 1438 ARG D CG  1 
ATOM   7256 C CD  . ARG F 3 94  ? -37.646 11.956  -64.948  1.00 55.54  ? 1438 ARG D CD  1 
ATOM   7257 N NE  . ARG F 3 94  ? -38.016 10.547  -64.987  1.00 84.13  ? 1438 ARG D NE  1 
ATOM   7258 C CZ  . ARG F 3 94  ? -39.257 10.094  -64.866  1.00 87.48  ? 1438 ARG D CZ  1 
ATOM   7259 N NH1 . ARG F 3 94  ? -40.276 10.916  -64.672  1.00 82.27  ? 1438 ARG D NH1 1 
ATOM   7260 N NH2 . ARG F 3 94  ? -39.480 8.785   -64.941  1.00 82.66  ? 1438 ARG D NH2 1 
ATOM   7261 N N   . ILE F 3 95  ? -34.625 12.819  -68.709  1.00 58.08  ? 1439 ILE D N   1 
ATOM   7262 C CA  . ILE F 3 95  ? -33.397 13.586  -68.524  1.00 54.90  ? 1439 ILE D CA  1 
ATOM   7263 C C   . ILE F 3 95  ? -33.278 14.662  -69.597  1.00 55.15  ? 1439 ILE D C   1 
ATOM   7264 O O   . ILE F 3 95  ? -33.069 15.843  -69.295  1.00 70.75  ? 1439 ILE D O   1 
ATOM   7265 C CB  . ILE F 3 95  ? -32.176 12.648  -68.522  1.00 52.35  ? 1439 ILE D CB  1 
ATOM   7266 C CG1 . ILE F 3 95  ? -32.157 11.805  -67.244  1.00 60.64  ? 1439 ILE D CG1 1 
ATOM   7267 C CG2 . ILE F 3 95  ? -30.887 13.444  -68.658  1.00 47.56  ? 1439 ILE D CG2 1 
ATOM   7268 C CD1 . ILE F 3 95  ? -31.082 10.738  -67.224  1.00 65.94  ? 1439 ILE D CD1 1 
ATOM   7269 N N   . ALA F 3 96  ? -33.423 14.272  -70.866  1.00 44.78  ? 1440 ALA D N   1 
ATOM   7270 C CA  . ALA F 3 96  ? -33.273 15.231  -71.955  1.00 46.28  ? 1440 ALA D CA  1 
ATOM   7271 C C   . ALA F 3 96  ? -34.409 16.244  -71.981  1.00 45.91  ? 1440 ALA D C   1 
ATOM   7272 O O   . ALA F 3 96  ? -34.218 17.374  -72.447  1.00 47.96  ? 1440 ALA D O   1 
ATOM   7273 C CB  . ALA F 3 96  ? -33.190 14.499  -73.290  1.00 34.09  ? 1440 ALA D CB  1 
ATOM   7274 N N   . ALA F 3 97  ? -35.593 15.863  -71.500  1.00 51.33  ? 1441 ALA D N   1 
ATOM   7275 C CA  . ALA F 3 97  ? -36.698 16.811  -71.431  1.00 43.87  ? 1441 ALA D CA  1 
ATOM   7276 C C   . ALA F 3 97  ? -36.398 17.926  -70.439  1.00 43.29  ? 1441 ALA D C   1 
ATOM   7277 O O   . ALA F 3 97  ? -36.576 19.109  -70.748  1.00 54.48  ? 1441 ALA D O   1 
ATOM   7278 C CB  . ALA F 3 97  ? -37.990 16.090  -71.054  1.00 47.26  ? 1441 ALA D CB  1 
ATOM   7279 N N   . HIS F 3 98  ? -35.937 17.567  -69.238  1.00 48.30  ? 1442 HIS D N   1 
ATOM   7280 C CA  . HIS F 3 98  ? -35.602 18.578  -68.242  1.00 49.23  ? 1442 HIS D CA  1 
ATOM   7281 C C   . HIS F 3 98  ? -34.373 19.379  -68.645  1.00 54.05  ? 1442 HIS D C   1 
ATOM   7282 O O   . HIS F 3 98  ? -34.265 20.561  -68.300  1.00 62.24  ? 1442 HIS D O   1 
ATOM   7283 C CB  . HIS F 3 98  ? -35.381 17.924  -66.880  1.00 41.50  ? 1442 HIS D CB  1 
ATOM   7284 C CG  . HIS F 3 98  ? -36.648 17.534  -66.189  1.00 46.64  ? 1442 HIS D CG  1 
ATOM   7285 N ND1 . HIS F 3 98  ? -37.120 16.240  -66.175  1.00 46.10  ? 1442 HIS D ND1 1 
ATOM   7286 C CD2 . HIS F 3 98  ? -37.546 18.270  -65.493  1.00 51.39  ? 1442 HIS D CD2 1 
ATOM   7287 C CE1 . HIS F 3 98  ? -38.252 16.194  -65.497  1.00 52.40  ? 1442 HIS D CE1 1 
ATOM   7288 N NE2 . HIS F 3 98  ? -38.533 17.412  -65.072  1.00 56.90  ? 1442 HIS D NE2 1 
ATOM   7289 N N   . HIS F 3 99  ? -33.437 18.752  -69.360  1.00 56.27  ? 1443 HIS D N   1 
ATOM   7290 C CA  . HIS F 3 99  ? -32.276 19.471  -69.874  1.00 48.73  ? 1443 HIS D CA  1 
ATOM   7291 C C   . HIS F 3 99  ? -32.708 20.596  -70.806  1.00 52.87  ? 1443 HIS D C   1 
ATOM   7292 O O   . HIS F 3 99  ? -32.387 21.769  -70.583  1.00 61.80  ? 1443 HIS D O   1 
ATOM   7293 C CB  . HIS F 3 99  ? -31.339 18.503  -70.598  1.00 51.53  ? 1443 HIS D CB  1 
ATOM   7294 C CG  . HIS F 3 99  ? -30.459 17.706  -69.685  1.00 51.22  ? 1443 HIS D CG  1 
ATOM   7295 N ND1 . HIS F 3 99  ? -30.384 17.937  -68.328  1.00 50.10  ? 1443 HIS D ND1 1 
ATOM   7296 C CD2 . HIS F 3 99  ? -29.609 16.682  -69.939  1.00 44.28  ? 1443 HIS D CD2 1 
ATOM   7297 C CE1 . HIS F 3 99  ? -29.530 17.088  -67.786  1.00 50.87  ? 1443 HIS D CE1 1 
ATOM   7298 N NE2 . HIS F 3 99  ? -29.045 16.316  -68.742  1.00 54.54  ? 1443 HIS D NE2 1 
ATOM   7299 N N   . MET F 3 100 ? -33.445 20.249  -71.864  1.00 36.89  ? 1444 MET D N   1 
ATOM   7300 C CA  . MET F 3 100 ? -33.943 21.260  -72.790  1.00 35.61  ? 1444 MET D CA  1 
ATOM   7301 C C   . MET F 3 100 ? -34.893 22.228  -72.099  1.00 44.19  ? 1444 MET D C   1 
ATOM   7302 O O   . MET F 3 100 ? -34.901 23.423  -72.417  1.00 54.13  ? 1444 MET D O   1 
ATOM   7303 C CB  . MET F 3 100 ? -34.630 20.584  -73.976  1.00 45.90  ? 1444 MET D CB  1 
ATOM   7304 C CG  . MET F 3 100 ? -35.445 21.514  -74.852  1.00 38.08  ? 1444 MET D CG  1 
ATOM   7305 S SD  . MET F 3 100 ? -36.279 20.633  -76.183  1.00 34.28  ? 1444 MET D SD  1 
ATOM   7306 C CE  . MET F 3 100 ? -36.335 21.899  -77.450  1.00 37.73  ? 1444 MET D CE  1 
ATOM   7307 N N   . MET F 3 101 ? -35.689 21.738  -71.145  1.00 51.79  ? 1445 MET D N   1 
ATOM   7308 C CA  . MET F 3 101 ? -36.614 22.610  -70.429  1.00 44.97  ? 1445 MET D CA  1 
ATOM   7309 C C   . MET F 3 101 ? -35.864 23.634  -69.583  1.00 54.48  ? 1445 MET D C   1 
ATOM   7310 O O   . MET F 3 101 ? -36.159 24.833  -69.639  1.00 59.89  ? 1445 MET D O   1 
ATOM   7311 C CB  . MET F 3 101 ? -37.556 21.783  -69.553  1.00 51.29  ? 1445 MET D CB  1 
ATOM   7312 C CG  . MET F 3 101 ? -38.602 22.615  -68.845  1.00 69.14  ? 1445 MET D CG  1 
ATOM   7313 S SD  . MET F 3 101 ? -39.172 23.964  -69.897  1.00 71.23  ? 1445 MET D SD  1 
ATOM   7314 C CE  . MET F 3 101 ? -40.915 23.953  -69.542  1.00 41.69  ? 1445 MET D CE  1 
ATOM   7315 N N   . ARG F 3 102 ? -34.898 23.173  -68.782  1.00 54.19  ? 1446 ARG D N   1 
ATOM   7316 C CA  . ARG F 3 102 ? -34.068 24.088  -68.002  1.00 53.85  ? 1446 ARG D CA  1 
ATOM   7317 C C   . ARG F 3 102 ? -33.492 25.198  -68.874  1.00 59.22  ? 1446 ARG D C   1 
ATOM   7318 O O   . ARG F 3 102 ? -33.449 26.364  -68.465  1.00 61.84  ? 1446 ARG D O   1 
ATOM   7319 C CB  . ARG F 3 102 ? -32.942 23.309  -67.316  1.00 67.40  ? 1446 ARG D CB  1 
ATOM   7320 C CG  . ARG F 3 102 ? -31.951 24.166  -66.540  1.00 77.38  ? 1446 ARG D CG  1 
ATOM   7321 C CD  . ARG F 3 102 ? -30.568 23.531  -66.481  1.00 85.16  ? 1446 ARG D CD  1 
ATOM   7322 N NE  . ARG F 3 102 ? -30.619 22.079  -66.345  1.00 94.30  ? 1446 ARG D NE  1 
ATOM   7323 C CZ  . ARG F 3 102 ? -30.880 21.435  -65.215  1.00 87.88  ? 1446 ARG D CZ  1 
ATOM   7324 N NH1 . ARG F 3 102 ? -31.135 22.085  -64.090  1.00 69.26  ? 1446 ARG D NH1 1 
ATOM   7325 N NH2 . ARG F 3 102 ? -30.888 20.105  -65.215  1.00 69.15  ? 1446 ARG D NH2 1 
ATOM   7326 N N   . ASN F 3 103 ? -33.068 24.853  -70.091  1.00 53.30  ? 1447 ASN D N   1 
ATOM   7327 C CA  . ASN F 3 103 ? -32.448 25.832  -70.978  1.00 45.50  ? 1447 ASN D CA  1 
ATOM   7328 C C   . ASN F 3 103 ? -33.486 26.782  -71.568  1.00 48.07  ? 1447 ASN D C   1 
ATOM   7329 O O   . ASN F 3 103 ? -33.339 28.006  -71.482  1.00 56.01  ? 1447 ASN D O   1 
ATOM   7330 C CB  . ASN F 3 103 ? -31.681 25.107  -72.083  1.00 46.77  ? 1447 ASN D CB  1 
ATOM   7331 C CG  . ASN F 3 103 ? -30.644 25.986  -72.754  1.00 57.12  ? 1447 ASN D CG  1 
ATOM   7332 O OD1 . ASN F 3 103 ? -30.974 26.831  -73.588  1.00 57.31  ? 1447 ASN D OD1 1 
ATOM   7333 N ND2 . ASN F 3 103 ? -29.380 25.788  -72.397  1.00 58.22  ? 1447 ASN D ND2 1 
ATOM   7334 N N   . LEU F 3 104 ? -34.544 26.234  -72.173  1.00 46.22  ? 1448 LEU D N   1 
ATOM   7335 C CA  . LEU F 3 104 ? -35.547 27.080  -72.816  1.00 44.30  ? 1448 LEU D CA  1 
ATOM   7336 C C   . LEU F 3 104 ? -36.271 27.963  -71.806  1.00 46.99  ? 1448 LEU D C   1 
ATOM   7337 O O   . LEU F 3 104 ? -36.665 29.087  -72.137  1.00 54.99  ? 1448 LEU D O   1 
ATOM   7338 C CB  . LEU F 3 104 ? -36.556 26.218  -73.579  1.00 30.75  ? 1448 LEU D CB  1 
ATOM   7339 C CG  . LEU F 3 104 ? -36.088 25.473  -74.834  1.00 36.24  ? 1448 LEU D CG  1 
ATOM   7340 C CD1 . LEU F 3 104 ? -37.216 25.364  -75.847  1.00 45.10  ? 1448 LEU D CD1 1 
ATOM   7341 C CD2 . LEU F 3 104 ? -34.866 26.121  -75.464  1.00 36.30  ? 1448 LEU D CD2 1 
ATOM   7342 N N   . THR F 3 105 ? -36.460 27.476  -70.577  1.00 49.31  ? 1449 THR D N   1 
ATOM   7343 C CA  . THR F 3 105 ? -37.131 28.284  -69.563  1.00 59.01  ? 1449 THR D CA  1 
ATOM   7344 C C   . THR F 3 105 ? -36.240 29.431  -69.105  1.00 61.25  ? 1449 THR D C   1 
ATOM   7345 O O   . THR F 3 105 ? -36.686 30.581  -69.020  1.00 59.79  ? 1449 THR D O   1 
ATOM   7346 C CB  . THR F 3 105 ? -37.537 27.422  -68.367  1.00 46.75  ? 1449 THR D CB  1 
ATOM   7347 O OG1 . THR F 3 105 ? -38.000 26.146  -68.822  1.00 44.77  ? 1449 THR D OG1 1 
ATOM   7348 C CG2 . THR F 3 105 ? -38.645 28.107  -67.581  1.00 43.12  ? 1449 THR D CG2 1 
ATOM   7349 N N   . ALA F 3 106 ? -34.974 29.132  -68.799  1.00 50.47  ? 1450 ALA D N   1 
ATOM   7350 C CA  . ALA F 3 106 ? -34.049 30.179  -68.381  1.00 46.71  ? 1450 ALA D CA  1 
ATOM   7351 C C   . ALA F 3 106 ? -33.853 31.220  -69.475  1.00 62.07  ? 1450 ALA D C   1 
ATOM   7352 O O   . ALA F 3 106 ? -33.657 32.403  -69.177  1.00 77.17  ? 1450 ALA D O   1 
ATOM   7353 C CB  . ALA F 3 106 ? -32.708 29.565  -67.976  1.00 44.34  ? 1450 ALA D CB  1 
ATOM   7354 N N   . GLY F 3 107 ? -33.910 30.805  -70.738  1.00 51.30  ? 1451 GLY D N   1 
ATOM   7355 C CA  . GLY F 3 107 ? -33.791 31.732  -71.845  1.00 43.44  ? 1451 GLY D CA  1 
ATOM   7356 C C   . GLY F 3 107 ? -34.956 32.697  -71.937  1.00 53.78  ? 1451 GLY D C   1 
ATOM   7357 O O   . GLY F 3 107 ? -34.760 33.915  -71.907  1.00 56.71  ? 1451 GLY D O   1 
ATOM   7358 N N   . MET F 3 108 ? -36.177 32.163  -72.048  1.00 65.92  ? 1452 MET D N   1 
ATOM   7359 C CA  . MET F 3 108 ? -37.359 33.015  -72.126  1.00 61.48  ? 1452 MET D CA  1 
ATOM   7360 C C   . MET F 3 108 ? -37.581 33.807  -70.846  1.00 59.04  ? 1452 MET D C   1 
ATOM   7361 O O   . MET F 3 108 ? -38.231 34.859  -70.885  1.00 61.32  ? 1452 MET D O   1 
ATOM   7362 C CB  . MET F 3 108 ? -38.602 32.178  -72.441  1.00 54.65  ? 1452 MET D CB  1 
ATOM   7363 C CG  . MET F 3 108 ? -38.888 32.017  -73.927  1.00 60.71  ? 1452 MET D CG  1 
ATOM   7364 S SD  . MET F 3 108 ? -38.955 33.592  -74.806  1.00 82.42  ? 1452 MET D SD  1 
ATOM   7365 C CE  . MET F 3 108 ? -40.717 33.913  -74.829  1.00 52.20  ? 1452 MET D CE  1 
ATOM   7366 N N   . ALA F 3 109 ? -37.062 33.327  -69.713  1.00 61.69  ? 1453 ALA D N   1 
ATOM   7367 C CA  . ALA F 3 109 ? -37.158 34.095  -68.476  1.00 61.75  ? 1453 ALA D CA  1 
ATOM   7368 C C   . ALA F 3 109 ? -36.255 35.320  -68.521  1.00 52.14  ? 1453 ALA D C   1 
ATOM   7369 O O   . ALA F 3 109 ? -36.643 36.401  -68.066  1.00 52.33  ? 1453 ALA D O   1 
ATOM   7370 C CB  . ALA F 3 109 ? -36.808 33.213  -67.279  1.00 55.13  ? 1453 ALA D CB  1 
ATOM   7371 N N   . MET F 3 110 ? -35.048 35.169  -69.072  1.00 55.98  ? 1454 MET D N   1 
ATOM   7372 C CA  . MET F 3 110 ? -34.127 36.296  -69.170  1.00 63.62  ? 1454 MET D CA  1 
ATOM   7373 C C   . MET F 3 110 ? -34.619 37.343  -70.165  1.00 63.21  ? 1454 MET D C   1 
ATOM   7374 O O   . MET F 3 110 ? -34.393 38.542  -69.965  1.00 74.05  ? 1454 MET D O   1 
ATOM   7375 C CB  . MET F 3 110 ? -32.737 35.790  -69.557  1.00 50.44  ? 1454 MET D CB  1 
ATOM   7376 C CG  . MET F 3 110 ? -31.784 36.859  -70.054  1.00 45.39  ? 1454 MET D CG  1 
ATOM   7377 S SD  . MET F 3 110 ? -30.352 36.157  -70.892  1.00 68.85  ? 1454 MET D SD  1 
ATOM   7378 C CE  . MET F 3 110 ? -30.337 34.494  -70.235  1.00 32.31  ? 1454 MET D CE  1 
ATOM   7379 N N   . ILE F 3 111 ? -35.297 36.915  -71.231  1.00 61.55  ? 1455 ILE D N   1 
ATOM   7380 C CA  . ILE F 3 111 ? -35.816 37.862  -72.213  1.00 58.06  ? 1455 ILE D CA  1 
ATOM   7381 C C   . ILE F 3 111 ? -36.898 38.738  -71.592  1.00 63.00  ? 1455 ILE D C   1 
ATOM   7382 O O   . ILE F 3 111 ? -36.987 39.938  -71.882  1.00 76.72  ? 1455 ILE D O   1 
ATOM   7383 C CB  . ILE F 3 111 ? -36.332 37.108  -73.454  1.00 50.20  ? 1455 ILE D CB  1 
ATOM   7384 C CG1 . ILE F 3 111 ? -35.167 36.483  -74.227  1.00 55.50  ? 1455 ILE D CG1 1 
ATOM   7385 C CG2 . ILE F 3 111 ? -37.140 38.029  -74.355  1.00 57.88  ? 1455 ILE D CG2 1 
ATOM   7386 C CD1 . ILE F 3 111 ? -33.920 37.352  -74.275  1.00 58.90  ? 1455 ILE D CD1 1 
ATOM   7387 N N   . THR F 3 112 ? -37.715 38.165  -70.710  1.00 55.25  ? 1456 THR D N   1 
ATOM   7388 C CA  . THR F 3 112 ? -38.871 38.851  -70.149  1.00 61.80  ? 1456 THR D CA  1 
ATOM   7389 C C   . THR F 3 112 ? -38.560 39.646  -68.883  1.00 69.66  ? 1456 THR D C   1 
ATOM   7390 O O   . THR F 3 112 ? -39.442 40.358  -68.389  1.00 66.70  ? 1456 THR D O   1 
ATOM   7391 C CB  . THR F 3 112 ? -39.976 37.832  -69.841  1.00 55.98  ? 1456 THR D CB  1 
ATOM   7392 O OG1 . THR F 3 112 ? -39.381 36.620  -69.362  1.00 56.30  ? 1456 THR D OG1 1 
ATOM   7393 C CG2 . THR F 3 112 ? -40.784 37.523  -71.094  1.00 55.64  ? 1456 THR D CG2 1 
ATOM   7394 N N   . CYS F 3 113 ? -37.337 39.563  -68.361  1.00 73.42  ? 1457 CYS D N   1 
ATOM   7395 C CA  . CYS F 3 113 ? -37.007 40.059  -67.029  1.00 57.98  ? 1457 CYS D CA  1 
ATOM   7396 C C   . CYS F 3 113 ? -36.116 41.293  -67.027  1.00 78.41  ? 1457 CYS D C   1 
ATOM   7397 O O   . CYS F 3 113 ? -36.407 42.256  -66.312  1.00 85.42  ? 1457 CYS D O   1 
ATOM   7398 C CB  . CYS F 3 113 ? -36.306 38.957  -66.225  1.00 45.78  ? 1457 CYS D CB  1 
ATOM   7399 S SG  . CYS F 3 113 ? -34.541 38.889  -66.632  1.00 145.71 ? 1457 CYS D SG  1 
ATOM   7400 N N   . ARG F 3 114 ? -35.023 41.278  -67.799  1.00 83.48  ? 1458 ARG D N   1 
ATOM   7401 C CA  . ARG F 3 114 ? -33.906 42.191  -67.554  1.00 80.38  ? 1458 ARG D CA  1 
ATOM   7402 C C   . ARG F 3 114 ? -34.338 43.650  -67.642  1.00 85.08  ? 1458 ARG D C   1 
ATOM   7403 O O   . ARG F 3 114 ? -34.184 44.413  -66.681  1.00 90.24  ? 1458 ARG D O   1 
ATOM   7404 C CB  . ARG F 3 114 ? -32.767 41.901  -68.535  1.00 65.57  ? 1458 ARG D CB  1 
ATOM   7405 C CG  . ARG F 3 114 ? -31.933 40.676  -68.181  1.00 68.79  ? 1458 ARG D CG  1 
ATOM   7406 C CD  . ARG F 3 114 ? -30.529 40.757  -68.762  1.00 80.76  ? 1458 ARG D CD  1 
ATOM   7407 N NE  . ARG F 3 114 ? -29.689 41.703  -68.036  1.00 96.71  ? 1458 ARG D NE  1 
ATOM   7408 C CZ  . ARG F 3 114 ? -28.427 41.476  -67.694  1.00 89.51  ? 1458 ARG D CZ  1 
ATOM   7409 N NH1 . ARG F 3 114 ? -27.823 40.337  -67.994  1.00 53.64  ? 1458 ARG D NH1 1 
ATOM   7410 N NH2 . ARG F 3 114 ? -27.755 42.416  -67.035  1.00 88.33  ? 1458 ARG D NH2 1 
ATOM   7411 N N   . GLU F 3 115 ? -34.880 44.058  -68.789  1.00 91.30  ? 1459 GLU D N   1 
ATOM   7412 C CA  . GLU F 3 115 ? -35.274 45.456  -68.954  1.00 95.94  ? 1459 GLU D CA  1 
ATOM   7413 C C   . GLU F 3 115 ? -36.314 45.897  -67.931  1.00 87.60  ? 1459 GLU D C   1 
ATOM   7414 O O   . GLU F 3 115 ? -36.159 46.994  -67.366  1.00 102.96 ? 1459 GLU D O   1 
ATOM   7415 C CB  . GLU F 3 115 ? -35.750 45.699  -70.392  1.00 124.32 ? 1459 GLU D CB  1 
ATOM   7416 C CG  . GLU F 3 115 ? -34.629 45.975  -71.391  1.00 127.12 ? 1459 GLU D CG  1 
ATOM   7417 C CD  . GLU F 3 115 ? -33.648 47.035  -70.914  1.00 121.93 ? 1459 GLU D CD  1 
ATOM   7418 O OE1 . GLU F 3 115 ? -34.096 48.089  -70.411  1.00 126.04 ? 1459 GLU D OE1 1 
ATOM   7419 O OE2 . GLU F 3 115 ? -32.427 46.817  -71.057  1.00 112.03 ? 1459 GLU D OE2 1 
ATOM   7420 N N   . PRO F 3 116 ? -37.378 45.131  -67.641  1.00 81.24  ? 1460 PRO D N   1 
ATOM   7421 C CA  . PRO F 3 116 ? -38.231 45.510  -66.501  1.00 71.64  ? 1460 PRO D CA  1 
ATOM   7422 C C   . PRO F 3 116 ? -37.477 45.558  -65.185  1.00 75.21  ? 1460 PRO D C   1 
ATOM   7423 O O   . PRO F 3 116 ? -37.738 46.443  -64.362  1.00 71.55  ? 1460 PRO D O   1 
ATOM   7424 C CB  . PRO F 3 116 ? -39.317 44.425  -66.499  1.00 49.42  ? 1460 PRO D CB  1 
ATOM   7425 C CG  . PRO F 3 116 ? -39.385 43.967  -67.904  1.00 72.19  ? 1460 PRO D CG  1 
ATOM   7426 C CD  . PRO F 3 116 ? -37.976 44.029  -68.420  1.00 84.59  ? 1460 PRO D CD  1 
ATOM   7427 N N   . LEU F 3 117 ? -36.535 44.635  -64.969  1.00 81.74  ? 1461 LEU D N   1 
ATOM   7428 C CA  . LEU F 3 117 ? -35.747 44.642  -63.739  1.00 73.85  ? 1461 LEU D CA  1 
ATOM   7429 C C   . LEU F 3 117 ? -34.780 45.820  -63.701  1.00 81.85  ? 1461 LEU D C   1 
ATOM   7430 O O   . LEU F 3 117 ? -34.580 46.427  -62.644  1.00 91.31  ? 1461 LEU D O   1 
ATOM   7431 C CB  . LEU F 3 117 ? -34.987 43.324  -63.595  1.00 61.09  ? 1461 LEU D CB  1 
ATOM   7432 C CG  . LEU F 3 117 ? -35.666 42.226  -62.775  1.00 68.66  ? 1461 LEU D CG  1 
ATOM   7433 C CD1 . LEU F 3 117 ? -34.644 41.211  -62.291  1.00 72.52  ? 1461 LEU D CD1 1 
ATOM   7434 C CD2 . LEU F 3 117 ? -36.431 42.823  -61.605  1.00 86.99  ? 1461 LEU D CD2 1 
ATOM   7435 N N   . LEU F 3 118 ? -34.158 46.146  -64.840  1.00 86.72  ? 1462 LEU D N   1 
ATOM   7436 C CA  . LEU F 3 118 ? -33.297 47.324  -64.910  1.00 78.48  ? 1462 LEU D CA  1 
ATOM   7437 C C   . LEU F 3 118 ? -34.038 48.576  -64.466  1.00 79.88  ? 1462 LEU D C   1 
ATOM   7438 O O   . LEU F 3 118 ? -33.479 49.426  -63.762  1.00 79.33  ? 1462 LEU D O   1 
ATOM   7439 C CB  . LEU F 3 118 ? -32.761 47.505  -66.332  1.00 95.80  ? 1462 LEU D CB  1 
ATOM   7440 C CG  . LEU F 3 118 ? -31.753 46.479  -66.850  1.00 99.84  ? 1462 LEU D CG  1 
ATOM   7441 C CD1 . LEU F 3 118 ? -31.150 46.928  -68.167  1.00 92.27  ? 1462 LEU D CD1 1 
ATOM   7442 C CD2 . LEU F 3 118 ? -30.665 46.289  -65.820  1.00 74.53  ? 1462 LEU D CD2 1 
ATOM   7443 N N   . MET F 3 119 ? -35.303 48.702  -64.865  1.00 86.77  ? 1463 MET D N   1 
ATOM   7444 C CA  . MET F 3 119 ? -36.128 49.834  -64.473  1.00 92.48  ? 1463 MET D CA  1 
ATOM   7445 C C   . MET F 3 119 ? -36.877 49.602  -63.169  1.00 87.73  ? 1463 MET D C   1 
ATOM   7446 O O   . MET F 3 119 ? -37.319 50.574  -62.549  1.00 91.73  ? 1463 MET D O   1 
ATOM   7447 C CB  . MET F 3 119 ? -37.126 50.168  -65.587  1.00 86.71  ? 1463 MET D CB  1 
ATOM   7448 C CG  . MET F 3 119 ? -36.492 50.270  -66.968  1.00 92.76  ? 1463 MET D CG  1 
ATOM   7449 S SD  . MET F 3 119 ? -37.667 50.712  -68.263  1.00 130.17 ? 1463 MET D SD  1 
ATOM   7450 C CE  . MET F 3 119 ? -37.200 49.562  -69.555  1.00 90.62  ? 1463 MET D CE  1 
ATOM   7451 N N   . SER F 3 120 ? -37.031 48.346  -62.736  1.00 95.04  ? 1464 SER D N   1 
ATOM   7452 C CA  . SER F 3 120 ? -37.658 48.088  -61.443  1.00 99.16  ? 1464 SER D CA  1 
ATOM   7453 C C   . SER F 3 120 ? -36.685 48.319  -60.293  1.00 94.30  ? 1464 SER D C   1 
ATOM   7454 O O   . SER F 3 120 ? -37.090 48.795  -59.228  1.00 106.92 ? 1464 SER D O   1 
ATOM   7455 C CB  . SER F 3 120 ? -38.209 46.662  -61.385  1.00 96.46  ? 1464 SER D CB  1 
ATOM   7456 O OG  . SER F 3 120 ? -39.345 46.586  -60.540  1.00 95.82  ? 1464 SER D OG  1 
ATOM   7457 N N   . ILE F 3 121 ? -35.406 47.989  -60.485  1.00 82.31  ? 1465 ILE D N   1 
ATOM   7458 C CA  . ILE F 3 121 ? -34.420 48.178  -59.421  1.00 89.16  ? 1465 ILE D CA  1 
ATOM   7459 C C   . ILE F 3 121 ? -34.248 49.662  -59.113  1.00 107.35 ? 1465 ILE D C   1 
ATOM   7460 O O   . ILE F 3 121 ? -34.405 50.100  -57.967  1.00 115.61 ? 1465 ILE D O   1 
ATOM   7461 C CB  . ILE F 3 121 ? -33.077 47.532  -59.802  1.00 74.59  ? 1465 ILE D CB  1 
ATOM   7462 C CG1 . ILE F 3 121 ? -33.198 46.006  -59.839  1.00 79.33  ? 1465 ILE D CG1 1 
ATOM   7463 C CG2 . ILE F 3 121 ? -31.997 47.957  -58.818  1.00 67.99  ? 1465 ILE D CG2 1 
ATOM   7464 C CD1 . ILE F 3 121 ? -31.871 45.278  -59.716  1.00 72.86  ? 1465 ILE D CD1 1 
ATOM   7465 N N   . SER F 3 122 ? -33.930 50.457  -60.138  1.00 102.59 ? 1466 SER D N   1 
ATOM   7466 C CA  . SER F 3 122 ? -33.556 51.850  -59.908  1.00 95.37  ? 1466 SER D CA  1 
ATOM   7467 C C   . SER F 3 122 ? -34.737 52.675  -59.409  1.00 96.92  ? 1466 SER D C   1 
ATOM   7468 O O   . SER F 3 122 ? -34.605 53.441  -58.446  1.00 111.07 ? 1466 SER D O   1 
ATOM   7469 C CB  . SER F 3 122 ? -32.971 52.453  -61.186  1.00 89.18  ? 1466 SER D CB  1 
ATOM   7470 O OG  . SER F 3 122 ? -32.077 53.511  -60.882  1.00 90.82  ? 1466 SER D OG  1 
ATOM   7471 N N   . THR F 3 123 ? -35.903 52.537  -60.050  1.00 88.57  ? 1467 THR D N   1 
ATOM   7472 C CA  . THR F 3 123 ? -37.074 53.298  -59.619  1.00 100.07 ? 1467 THR D CA  1 
ATOM   7473 C C   . THR F 3 123 ? -37.469 52.942  -58.189  1.00 110.34 ? 1467 THR D C   1 
ATOM   7474 O O   . THR F 3 123 ? -37.845 53.820  -57.403  1.00 97.19  ? 1467 THR D O   1 
ATOM   7475 C CB  . THR F 3 123 ? -38.250 53.055  -60.567  1.00 95.68  ? 1467 THR D CB  1 
ATOM   7476 O OG1 . THR F 3 123 ? -38.242 51.692  -61.005  1.00 114.69 ? 1467 THR D OG1 1 
ATOM   7477 C CG2 . THR F 3 123 ? -38.160 53.972  -61.782  1.00 93.84  ? 1467 THR D CG2 1 
ATOM   7478 N N   . ASN F 3 124 ? -37.388 51.655  -57.835  1.00 119.85 ? 1468 ASN D N   1 
ATOM   7479 C CA  . ASN F 3 124 ? -37.681 51.242  -56.466  1.00 114.51 ? 1468 ASN D CA  1 
ATOM   7480 C C   . ASN F 3 124 ? -36.661 51.798  -55.482  1.00 122.92 ? 1468 ASN D C   1 
ATOM   7481 O O   . ASN F 3 124 ? -37.006 52.066  -54.325  1.00 143.94 ? 1468 ASN D O   1 
ATOM   7482 C CB  . ASN F 3 124 ? -37.717 49.716  -56.363  1.00 103.23 ? 1468 ASN D CB  1 
ATOM   7483 C CG  . ASN F 3 124 ? -39.079 49.135  -56.693  1.00 106.09 ? 1468 ASN D CG  1 
ATOM   7484 O OD1 . ASN F 3 124 ? -40.055 49.865  -56.870  1.00 100.51 ? 1468 ASN D OD1 1 
ATOM   7485 N ND2 . ASN F 3 124 ? -39.149 47.811  -56.784  1.00 105.20 ? 1468 ASN D ND2 1 
ATOM   7486 N N   . LEU F 3 125 ? -35.408 51.967  -55.917  1.00 103.28 ? 1469 LEU D N   1 
ATOM   7487 C CA  . LEU F 3 125 ? -34.378 52.503  -55.031  1.00 103.34 ? 1469 LEU D CA  1 
ATOM   7488 C C   . LEU F 3 125 ? -34.801 53.847  -54.449  1.00 126.94 ? 1469 LEU D C   1 
ATOM   7489 O O   . LEU F 3 125 ? -34.815 54.026  -53.225  1.00 132.61 ? 1469 LEU D O   1 
ATOM   7490 C CB  . LEU F 3 125 ? -33.047 52.628  -55.776  1.00 79.39  ? 1469 LEU D CB  1 
ATOM   7491 C CG  . LEU F 3 125 ? -32.269 51.323  -55.967  1.00 90.97  ? 1469 LEU D CG  1 
ATOM   7492 C CD1 . LEU F 3 125 ? -31.318 51.400  -57.152  1.00 78.68  ? 1469 LEU D CD1 1 
ATOM   7493 C CD2 . LEU F 3 125 ? -31.515 50.962  -54.703  1.00 105.31 ? 1469 LEU D CD2 1 
ATOM   7494 N N   . LYS F 3 126 ? -35.153 54.803  -55.313  1.00 111.42 ? 1470 LYS D N   1 
ATOM   7495 C CA  . LYS F 3 126 ? -35.713 56.087  -54.899  1.00 95.04  ? 1470 LYS D CA  1 
ATOM   7496 C C   . LYS F 3 126 ? -34.782 56.845  -53.955  1.00 117.43 ? 1470 LYS D C   1 
ATOM   7497 O O   . LYS F 3 126 ? -34.339 57.952  -54.278  1.00 128.56 ? 1470 LYS D O   1 
ATOM   7498 C CB  . LYS F 3 126 ? -37.080 55.876  -54.243  1.00 90.28  ? 1470 LYS D CB  1 
ATOM   7499 C CG  . LYS F 3 126 ? -37.921 57.130  -54.128  1.00 93.23  ? 1470 LYS D CG  1 
ATOM   7500 C CD  . LYS F 3 126 ? -39.317 56.793  -53.634  1.00 79.37  ? 1470 LYS D CD  1 
ATOM   7501 C CE  . LYS F 3 126 ? -40.274 56.544  -54.784  1.00 71.71  ? 1470 LYS D CE  1 
ATOM   7502 N NZ  . LYS F 3 126 ? -41.223 57.678  -54.950  1.00 76.15  ? 1470 LYS D NZ  1 
ATOM   7503 N N   . ASN F 3 127 ? -34.510 56.260  -52.783  1.00 127.37 ? 1471 ASN D N   1 
ATOM   7504 C CA  . ASN F 3 127 ? -33.557 56.759  -51.792  1.00 120.08 ? 1471 ASN D CA  1 
ATOM   7505 C C   . ASN F 3 127 ? -34.053 58.009  -51.070  1.00 115.09 ? 1471 ASN D C   1 
ATOM   7506 O O   . ASN F 3 127 ? -34.018 58.070  -49.836  1.00 103.02 ? 1471 ASN D O   1 
ATOM   7507 C CB  . ASN F 3 127 ? -32.187 57.039  -52.428  1.00 111.13 ? 1471 ASN D CB  1 
ATOM   7508 C CG  . ASN F 3 127 ? -31.662 55.869  -53.247  1.00 117.52 ? 1471 ASN D CG  1 
ATOM   7509 O OD1 . ASN F 3 127 ? -32.065 55.662  -54.393  1.00 105.06 ? 1471 ASN D OD1 1 
ATOM   7510 N ND2 . ASN F 3 127 ? -30.751 55.100  -52.659  1.00 107.33 ? 1471 ASN D ND2 1 
ATOM   7511 N N   . SER F 3 128 ? -34.525 59.005  -51.823  1.00 125.30 ? 1472 SER D N   1 
ATOM   7512 C CA  . SER F 3 128 ? -34.781 60.320  -51.242  1.00 119.68 ? 1472 SER D CA  1 
ATOM   7513 C C   . SER F 3 128 ? -36.028 60.325  -50.363  1.00 132.03 ? 1472 SER D C   1 
ATOM   7514 O O   . SER F 3 128 ? -36.038 60.965  -49.304  1.00 139.62 ? 1472 SER D O   1 
ATOM   7515 C CB  . SER F 3 128 ? -34.904 61.366  -52.350  1.00 128.16 ? 1472 SER D CB  1 
ATOM   7516 O OG  . SER F 3 128 ? -36.254 61.532  -52.749  1.00 123.15 ? 1472 SER D OG  1 
ATOM   7517 N N   . PHE F 3 129 ? -37.089 59.630  -50.789  1.00 125.85 ? 1473 PHE D N   1 
ATOM   7518 C CA  . PHE F 3 129 ? -38.353 59.654  -50.052  1.00 119.25 ? 1473 PHE D CA  1 
ATOM   7519 C C   . PHE F 3 129 ? -38.163 59.243  -48.596  1.00 129.67 ? 1473 PHE D C   1 
ATOM   7520 O O   . PHE F 3 129 ? -38.730 59.862  -47.688  1.00 131.02 ? 1473 PHE D O   1 
ATOM   7521 C CB  . PHE F 3 129 ? -39.374 58.739  -50.733  1.00 120.79 ? 1473 PHE D CB  1 
ATOM   7522 C CG  . PHE F 3 129 ? -40.781 59.281  -50.740  1.00 124.68 ? 1473 PHE D CG  1 
ATOM   7523 C CD1 . PHE F 3 129 ? -41.533 59.315  -49.576  1.00 112.06 ? 1473 PHE D CD1 1 
ATOM   7524 C CD2 . PHE F 3 129 ? -41.359 59.736  -51.917  1.00 114.11 ? 1473 PHE D CD2 1 
ATOM   7525 C CE1 . PHE F 3 129 ? -42.828 59.805  -49.581  1.00 100.23 ? 1473 PHE D CE1 1 
ATOM   7526 C CE2 . PHE F 3 129 ? -42.655 60.226  -51.929  1.00 75.23  ? 1473 PHE D CE2 1 
ATOM   7527 C CZ  . PHE F 3 129 ? -43.389 60.261  -50.759  1.00 91.66  ? 1473 PHE D CZ  1 
ATOM   7528 N N   . ALA F 3 130 ? -37.364 58.208  -48.354  1.00 121.95 ? 1474 ALA D N   1 
ATOM   7529 C CA  . ALA F 3 130 ? -37.065 57.771  -46.996  1.00 95.18  ? 1474 ALA D CA  1 
ATOM   7530 C C   . ALA F 3 130 ? -35.875 58.540  -46.429  1.00 104.13 ? 1474 ALA D C   1 
ATOM   7531 O O   . ALA F 3 130 ? -34.747 58.400  -46.904  1.00 95.68  ? 1474 ALA D O   1 
ATOM   7532 C CB  . ALA F 3 130 ? -36.794 56.277  -46.969  1.00 85.67  ? 1474 ALA D CB  1 
ATOM   7533 N N   . ARG F 3 134 ? -33.837 63.318  -48.166  1.00 121.87 ? 1478 ARG D N   1 
ATOM   7534 C CA  . ARG F 3 134 ? -34.658 64.306  -48.854  1.00 136.08 ? 1478 ARG D CA  1 
ATOM   7535 C C   . ARG F 3 134 ? -34.132 65.717  -48.604  1.00 152.93 ? 1478 ARG D C   1 
ATOM   7536 O O   . ARG F 3 134 ? -33.242 65.916  -47.773  1.00 155.72 ? 1478 ARG D O   1 
ATOM   7537 C CB  . ARG F 3 134 ? -36.118 64.189  -48.412  1.00 123.60 ? 1478 ARG D CB  1 
ATOM   7538 C CG  . ARG F 3 134 ? -37.123 64.424  -49.528  1.00 109.87 ? 1478 ARG D CG  1 
ATOM   7539 C CD  . ARG F 3 134 ? -38.506 64.704  -48.969  1.00 105.83 ? 1478 ARG D CD  1 
ATOM   7540 N NE  . ARG F 3 134 ? -39.119 63.497  -48.427  1.00 125.87 ? 1478 ARG D NE  1 
ATOM   7541 C CZ  . ARG F 3 134 ? -40.421 63.250  -48.431  1.00 119.43 ? 1478 ARG D CZ  1 
ATOM   7542 N NH1 . ARG F 3 134 ? -41.287 64.113  -48.938  1.00 107.34 ? 1478 ARG D NH1 1 
ATOM   7543 N NH2 . ARG F 3 134 ? -40.867 62.109  -47.913  1.00 113.22 ? 1478 ARG D NH2 1 
ATOM   7544 N N   . THR F 3 135 ? -34.697 66.687  -49.328  1.00 157.17 ? 1479 THR D N   1 
ATOM   7545 C CA  . THR F 3 135 ? -34.238 68.077  -49.368  1.00 156.60 ? 1479 THR D CA  1 
ATOM   7546 C C   . THR F 3 135 ? -32.831 68.204  -49.949  1.00 158.64 ? 1479 THR D C   1 
ATOM   7547 O O   . THR F 3 135 ? -32.170 69.233  -49.768  1.00 157.73 ? 1479 THR D O   1 
ATOM   7548 C CB  . THR F 3 135 ? -34.305 68.749  -47.987  1.00 164.07 ? 1479 THR D CB  1 
ATOM   7549 O OG1 . THR F 3 135 ? -33.315 68.180  -47.118  1.00 176.42 ? 1479 THR D OG1 1 
ATOM   7550 C CG2 . THR F 3 135 ? -35.686 68.574  -47.370  1.00 136.24 ? 1479 THR D CG2 1 
ATOM   7551 N N   . ALA F 3 136 ? -32.360 67.178  -50.652  1.00 156.70 ? 1480 ALA D N   1 
ATOM   7552 C CA  . ALA F 3 136 ? -31.084 67.268  -51.343  1.00 143.46 ? 1480 ALA D CA  1 
ATOM   7553 C C   . ALA F 3 136 ? -31.225 68.121  -52.601  1.00 152.02 ? 1480 ALA D C   1 
ATOM   7554 O O   . ALA F 3 136 ? -32.282 68.160  -53.236  1.00 150.38 ? 1480 ALA D O   1 
ATOM   7555 C CB  . ALA F 3 136 ? -30.567 65.874  -51.700  1.00 119.16 ? 1480 ALA D CB  1 
ATOM   7556 N N   . SER F 3 137 ? -30.143 68.812  -52.953  1.00 152.90 ? 1481 SER D N   1 
ATOM   7557 C CA  . SER F 3 137 ? -30.159 69.732  -54.079  1.00 150.77 ? 1481 SER D CA  1 
ATOM   7558 C C   . SER F 3 137 ? -30.376 68.980  -55.393  1.00 150.78 ? 1481 SER D C   1 
ATOM   7559 O O   . SER F 3 137 ? -30.219 67.758  -55.452  1.00 158.16 ? 1481 SER D O   1 
ATOM   7560 C CB  . SER F 3 137 ? -28.853 70.522  -54.130  1.00 140.23 ? 1481 SER D CB  1 
ATOM   7561 O OG  . SER F 3 137 ? -28.972 71.749  -53.430  1.00 118.47 ? 1481 SER D OG  1 
ATOM   7562 N N   . PRO F 3 138 ? -30.761 69.692  -56.461  1.00 151.24 ? 1482 PRO D N   1 
ATOM   7563 C CA  . PRO F 3 138 ? -30.883 69.020  -57.767  1.00 155.86 ? 1482 PRO D CA  1 
ATOM   7564 C C   . PRO F 3 138 ? -29.591 68.369  -58.229  1.00 157.12 ? 1482 PRO D C   1 
ATOM   7565 O O   . PRO F 3 138 ? -29.631 67.303  -58.856  1.00 153.91 ? 1482 PRO D O   1 
ATOM   7566 C CB  . PRO F 3 138 ? -31.327 70.157  -58.703  1.00 140.12 ? 1482 PRO D CB  1 
ATOM   7567 C CG  . PRO F 3 138 ? -30.989 71.426  -57.959  1.00 133.67 ? 1482 PRO D CG  1 
ATOM   7568 C CD  . PRO F 3 138 ? -31.241 71.081  -56.530  1.00 135.10 ? 1482 PRO D CD  1 
ATOM   7569 N N   . GLN F 3 139 ? -28.439 68.979  -57.935  1.00 161.72 ? 1483 GLN D N   1 
ATOM   7570 C CA  . GLN F 3 139 ? -27.169 68.306  -58.186  1.00 161.96 ? 1483 GLN D CA  1 
ATOM   7571 C C   . GLN F 3 139 ? -26.962 67.139  -57.228  1.00 166.84 ? 1483 GLN D C   1 
ATOM   7572 O O   . GLN F 3 139 ? -26.329 66.141  -57.595  1.00 160.26 ? 1483 GLN D O   1 
ATOM   7573 C CB  . GLN F 3 139 ? -26.012 69.301  -58.077  1.00 150.41 ? 1483 GLN D CB  1 
ATOM   7574 C CG  . GLN F 3 139 ? -26.040 70.172  -56.826  1.00 134.08 ? 1483 GLN D CG  1 
ATOM   7575 C CD  . GLN F 3 139 ? -25.255 69.574  -55.673  1.00 130.54 ? 1483 GLN D CD  1 
ATOM   7576 O OE1 . GLN F 3 139 ? -24.701 68.481  -55.784  1.00 140.96 ? 1483 GLN D OE1 1 
ATOM   7577 N NE2 . GLN F 3 139 ? -25.204 70.293  -54.557  1.00 115.96 ? 1483 GLN D NE2 1 
ATOM   7578 N N   . GLN F 3 140 ? -27.482 67.245  -56.002  1.00 164.99 ? 1484 GLN D N   1 
ATOM   7579 C CA  . GLN F 3 140 ? -27.382 66.141  -55.054  1.00 142.02 ? 1484 GLN D CA  1 
ATOM   7580 C C   . GLN F 3 140 ? -28.316 64.997  -55.429  1.00 142.69 ? 1484 GLN D C   1 
ATOM   7581 O O   . GLN F 3 140 ? -28.005 63.830  -55.166  1.00 133.57 ? 1484 GLN D O   1 
ATOM   7582 C CB  . GLN F 3 140 ? -27.686 66.638  -53.640  1.00 133.88 ? 1484 GLN D CB  1 
ATOM   7583 C CG  . GLN F 3 140 ? -26.724 67.699  -53.124  1.00 127.90 ? 1484 GLN D CG  1 
ATOM   7584 C CD  . GLN F 3 140 ? -26.185 67.377  -51.745  1.00 117.79 ? 1484 GLN D CD  1 
ATOM   7585 O OE1 . GLN F 3 140 ? -26.217 66.227  -51.308  1.00 119.51 ? 1484 GLN D OE1 1 
ATOM   7586 N NE2 . GLN F 3 140 ? -25.682 68.393  -51.052  1.00 99.05  ? 1484 GLN D NE2 1 
ATOM   7587 N N   . ARG F 3 141 ? -29.462 65.313  -56.037  1.00 149.79 ? 1485 ARG D N   1 
ATOM   7588 C CA  . ARG F 3 141 ? -30.363 64.277  -56.533  1.00 137.81 ? 1485 ARG D CA  1 
ATOM   7589 C C   . ARG F 3 141 ? -29.707 63.479  -57.655  1.00 144.69 ? 1485 ARG D C   1 
ATOM   7590 O O   . ARG F 3 141 ? -29.831 62.250  -57.706  1.00 143.11 ? 1485 ARG D O   1 
ATOM   7591 C CB  . ARG F 3 141 ? -31.674 64.924  -56.996  1.00 127.42 ? 1485 ARG D CB  1 
ATOM   7592 C CG  . ARG F 3 141 ? -32.724 64.020  -57.670  1.00 120.57 ? 1485 ARG D CG  1 
ATOM   7593 C CD  . ARG F 3 141 ? -32.402 63.662  -59.128  1.00 124.66 ? 1485 ARG D CD  1 
ATOM   7594 N NE  . ARG F 3 141 ? -32.182 64.814  -60.004  1.00 121.86 ? 1485 ARG D NE  1 
ATOM   7595 C CZ  . ARG F 3 141 ? -33.022 65.831  -60.163  1.00 124.06 ? 1485 ARG D CZ  1 
ATOM   7596 N NH1 . ARG F 3 141 ? -34.209 65.853  -59.574  1.00 128.87 ? 1485 ARG D NH1 1 
ATOM   7597 N NH2 . ARG F 3 141 ? -32.675 66.838  -60.959  1.00 114.62 ? 1485 ARG D NH2 1 
ATOM   7598 N N   . GLU F 3 142 ? -29.005 64.167  -58.563  1.00 155.12 ? 1486 GLU D N   1 
ATOM   7599 C CA  . GLU F 3 142 ? -28.421 63.508  -59.729  1.00 153.20 ? 1486 GLU D CA  1 
ATOM   7600 C C   . GLU F 3 142 ? -27.421 62.438  -59.315  1.00 158.02 ? 1486 GLU D C   1 
ATOM   7601 O O   . GLU F 3 142 ? -27.487 61.296  -59.783  1.00 167.70 ? 1486 GLU D O   1 
ATOM   7602 C CB  . GLU F 3 142 ? -27.751 64.545  -60.633  1.00 148.20 ? 1486 GLU D CB  1 
ATOM   7603 C CG  . GLU F 3 142 ? -27.404 64.028  -62.027  1.00 147.50 ? 1486 GLU D CG  1 
ATOM   7604 C CD  . GLU F 3 142 ? -26.049 63.335  -62.090  1.00 145.65 ? 1486 GLU D CD  1 
ATOM   7605 O OE1 . GLU F 3 142 ? -25.276 63.426  -61.113  1.00 146.52 ? 1486 GLU D OE1 1 
ATOM   7606 O OE2 . GLU F 3 142 ? -25.763 62.689  -63.119  1.00 136.22 ? 1486 GLU D OE2 1 
ATOM   7607 N N   . MET F 3 143 ? -26.474 62.793  -58.443  1.00 146.67 ? 1487 MET D N   1 
ATOM   7608 C CA  . MET F 3 143 ? -25.464 61.832  -58.022  1.00 128.99 ? 1487 MET D CA  1 
ATOM   7609 C C   . MET F 3 143 ? -26.060 60.684  -57.217  1.00 148.13 ? 1487 MET D C   1 
ATOM   7610 O O   . MET F 3 143 ? -25.416 59.638  -57.082  1.00 142.60 ? 1487 MET D O   1 
ATOM   7611 C CB  . MET F 3 143 ? -24.369 62.540  -57.226  1.00 122.42 ? 1487 MET D CB  1 
ATOM   7612 C CG  . MET F 3 143 ? -24.656 62.748  -55.748  1.00 129.24 ? 1487 MET D CG  1 
ATOM   7613 S SD  . MET F 3 143 ? -23.956 64.308  -55.174  1.00 122.74 ? 1487 MET D SD  1 
ATOM   7614 C CE  . MET F 3 143 ? -24.672 64.439  -53.539  1.00 87.98  ? 1487 MET D CE  1 
ATOM   7615 N N   . MET F 3 144 ? -27.270 60.858  -56.679  1.00 156.67 ? 1488 MET D N   1 
ATOM   7616 C CA  . MET F 3 144 ? -28.008 59.722  -56.136  1.00 147.54 ? 1488 MET D CA  1 
ATOM   7617 C C   . MET F 3 144 ? -28.570 58.851  -57.252  1.00 151.16 ? 1488 MET D C   1 
ATOM   7618 O O   . MET F 3 144 ? -28.510 57.618  -57.177  1.00 143.70 ? 1488 MET D O   1 
ATOM   7619 C CB  . MET F 3 144 ? -29.142 60.207  -55.233  1.00 131.71 ? 1488 MET D CB  1 
ATOM   7620 C CG  . MET F 3 144 ? -28.759 60.374  -53.782  1.00 113.55 ? 1488 MET D CG  1 
ATOM   7621 S SD  . MET F 3 144 ? -30.117 60.945  -52.744  1.00 129.47 ? 1488 MET D SD  1 
ATOM   7622 C CE  . MET F 3 144 ? -31.478 60.970  -53.909  1.00 108.15 ? 1488 MET D CE  1 
ATOM   7623 N N   . ASP F 3 145 ? -29.126 59.478  -58.293  1.00 155.10 ? 1489 ASP D N   1 
ATOM   7624 C CA  . ASP F 3 145 ? -29.706 58.721  -59.398  1.00 142.98 ? 1489 ASP D CA  1 
ATOM   7625 C C   . ASP F 3 145 ? -28.632 58.004  -60.205  1.00 136.42 ? 1489 ASP D C   1 
ATOM   7626 O O   . ASP F 3 145 ? -28.854 56.888  -60.688  1.00 142.83 ? 1489 ASP D O   1 
ATOM   7627 C CB  . ASP F 3 145 ? -30.520 59.647  -60.303  1.00 125.26 ? 1489 ASP D CB  1 
ATOM   7628 C CG  . ASP F 3 145 ? -31.760 60.192  -59.622  1.00 128.00 ? 1489 ASP D CG  1 
ATOM   7629 O OD1 . ASP F 3 145 ? -31.848 60.115  -58.377  1.00 122.10 ? 1489 ASP D OD1 1 
ATOM   7630 O OD2 . ASP F 3 145 ? -32.652 60.694  -60.336  1.00 130.80 ? 1489 ASP D OD2 1 
ATOM   7631 N N   . GLN F 3 146 ? -27.466 58.634  -60.373  1.00 138.01 ? 1490 GLN D N   1 
ATOM   7632 C CA  . GLN F 3 146 ? -26.368 57.977  -61.076  1.00 144.40 ? 1490 GLN D CA  1 
ATOM   7633 C C   . GLN F 3 146 ? -25.867 56.768  -60.295  1.00 149.03 ? 1490 GLN D C   1 
ATOM   7634 O O   . GLN F 3 146 ? -25.535 55.733  -60.886  1.00 159.89 ? 1490 GLN D O   1 
ATOM   7635 C CB  . GLN F 3 146 ? -25.233 58.972  -61.327  1.00 144.24 ? 1490 GLN D CB  1 
ATOM   7636 C CG  . GLN F 3 146 ? -23.940 58.336  -61.822  1.00 135.06 ? 1490 GLN D CG  1 
ATOM   7637 C CD  . GLN F 3 146 ? -22.706 59.107  -61.394  1.00 127.72 ? 1490 GLN D CD  1 
ATOM   7638 O OE1 . GLN F 3 146 ? -22.801 60.121  -60.703  1.00 132.97 ? 1490 GLN D OE1 1 
ATOM   7639 N NE2 . GLN F 3 146 ? -21.536 58.624  -61.800  1.00 98.29  ? 1490 GLN D NE2 1 
ATOM   7640 N N   . ALA F 3 147 ? -25.812 56.877  -58.965  1.00 142.68 ? 1491 ALA D N   1 
ATOM   7641 C CA  . ALA F 3 147 ? -25.440 55.730  -58.144  1.00 142.61 ? 1491 ALA D CA  1 
ATOM   7642 C C   . ALA F 3 147 ? -26.510 54.646  -58.181  1.00 150.45 ? 1491 ALA D C   1 
ATOM   7643 O O   . ALA F 3 147 ? -26.187 53.454  -58.126  1.00 141.52 ? 1491 ALA D O   1 
ATOM   7644 C CB  . ALA F 3 147 ? -25.183 56.173  -56.704  1.00 127.15 ? 1491 ALA D CB  1 
ATOM   7645 N N   . ALA F 3 148 ? -27.784 55.037  -58.272  1.00 153.88 ? 1492 ALA D N   1 
ATOM   7646 C CA  . ALA F 3 148 ? -28.862 54.055  -58.318  1.00 131.51 ? 1492 ALA D CA  1 
ATOM   7647 C C   . ALA F 3 148 ? -28.893 53.333  -59.660  1.00 129.62 ? 1492 ALA D C   1 
ATOM   7648 O O   . ALA F 3 148 ? -28.994 52.101  -59.711  1.00 120.50 ? 1492 ALA D O   1 
ATOM   7649 C CB  . ALA F 3 148 ? -30.203 54.736  -58.038  1.00 112.52 ? 1492 ALA D CB  1 
ATOM   7650 N N   . ALA F 3 149 ? -28.813 54.087  -60.761  1.00 136.01 ? 1493 ALA D N   1 
ATOM   7651 C CA  . ALA F 3 149 ? -28.831 53.470  -62.083  1.00 115.53 ? 1493 ALA D CA  1 
ATOM   7652 C C   . ALA F 3 149 ? -27.612 52.590  -62.303  1.00 124.93 ? 1493 ALA D C   1 
ATOM   7653 O O   . ALA F 3 149 ? -27.677 51.614  -63.061  1.00 136.15 ? 1493 ALA D O   1 
ATOM   7654 C CB  . ALA F 3 149 ? -28.918 54.546  -63.164  1.00 111.11 ? 1493 ALA D CB  1 
ATOM   7655 N N   . GLN F 3 150 ? -26.496 52.910  -61.651  1.00 116.92 ? 1494 GLN D N   1 
ATOM   7656 C CA  . GLN F 3 150 ? -25.340 52.027  -61.705  1.00 115.47 ? 1494 GLN D CA  1 
ATOM   7657 C C   . GLN F 3 150 ? -25.633 50.731  -60.962  1.00 129.52 ? 1494 GLN D C   1 
ATOM   7658 O O   . GLN F 3 150 ? -25.616 49.645  -61.548  1.00 134.63 ? 1494 GLN D O   1 
ATOM   7659 C CB  . GLN F 3 150 ? -24.113 52.741  -61.122  1.00 110.07 ? 1494 GLN D CB  1 
ATOM   7660 C CG  . GLN F 3 150 ? -22.789 52.091  -61.454  1.00 104.43 ? 1494 GLN D CG  1 
ATOM   7661 C CD  . GLN F 3 150 ? -22.441 50.901  -60.570  1.00 101.29 ? 1494 GLN D CD  1 
ATOM   7662 O OE1 . GLN F 3 150 ? -23.253 50.424  -59.765  1.00 106.23 ? 1494 GLN D OE1 1 
ATOM   7663 N NE2 . GLN F 3 150 ? -21.227 50.386  -60.754  1.00 100.15 ? 1494 GLN D NE2 1 
ATOM   7664 N N   . LEU F 3 151 ? -25.922 50.835  -59.658  1.00 133.63 ? 1495 LEU D N   1 
ATOM   7665 C CA  . LEU F 3 151 ? -26.190 49.656  -58.836  1.00 124.04 ? 1495 LEU D CA  1 
ATOM   7666 C C   . LEU F 3 151 ? -27.316 48.806  -59.415  1.00 127.59 ? 1495 LEU D C   1 
ATOM   7667 O O   . LEU F 3 151 ? -27.373 47.597  -59.161  1.00 114.83 ? 1495 LEU D O   1 
ATOM   7668 C CB  . LEU F 3 151 ? -26.525 50.088  -57.406  1.00 109.76 ? 1495 LEU D CB  1 
ATOM   7669 C CG  . LEU F 3 151 ? -25.344 50.180  -56.434  1.00 94.65  ? 1495 LEU D CG  1 
ATOM   7670 C CD1 . LEU F 3 151 ? -25.802 50.629  -55.053  1.00 83.45  ? 1495 LEU D CD1 1 
ATOM   7671 C CD2 . LEU F 3 151 ? -24.586 48.860  -56.353  1.00 75.83  ? 1495 LEU D CD2 1 
ATOM   7672 N N   . ALA F 3 152 ? -28.216 49.414  -60.193  1.00 133.65 ? 1496 ALA D N   1 
ATOM   7673 C CA  . ALA F 3 152 ? -29.206 48.631  -60.923  1.00 106.50 ? 1496 ALA D CA  1 
ATOM   7674 C C   . ALA F 3 152 ? -28.540 47.763  -61.983  1.00 106.48 ? 1496 ALA D C   1 
ATOM   7675 O O   . ALA F 3 152 ? -28.928 46.607  -62.182  1.00 117.63 ? 1496 ALA D O   1 
ATOM   7676 C CB  . ALA F 3 152 ? -30.246 49.555  -61.555  1.00 85.85  ? 1496 ALA D CB  1 
ATOM   7677 N N   . GLN F 3 153 ? -27.528 48.302  -62.668  1.00 111.52 ? 1497 GLN D N   1 
ATOM   7678 C CA  . GLN F 3 153 ? -26.806 47.526  -63.671  1.00 115.60 ? 1497 GLN D CA  1 
ATOM   7679 C C   . GLN F 3 153 ? -25.871 46.504  -63.031  1.00 109.48 ? 1497 GLN D C   1 
ATOM   7680 O O   . GLN F 3 153 ? -25.642 45.434  -63.607  1.00 110.56 ? 1497 GLN D O   1 
ATOM   7681 C CB  . GLN F 3 153 ? -26.031 48.470  -64.598  1.00 110.94 ? 1497 GLN D CB  1 
ATOM   7682 C CG  . GLN F 3 153 ? -24.701 47.935  -65.114  1.00 113.19 ? 1497 GLN D CG  1 
ATOM   7683 C CD  . GLN F 3 153 ? -23.904 48.980  -65.873  1.00 95.60  ? 1497 GLN D CD  1 
ATOM   7684 O OE1 . GLN F 3 153 ? -24.358 50.109  -66.058  1.00 92.04  ? 1497 GLN D OE1 1 
ATOM   7685 N NE2 . GLN F 3 153 ? -22.711 48.606  -66.322  1.00 101.88 ? 1497 GLN D NE2 1 
ATOM   7686 N N   . ASP F 3 154 ? -25.344 46.803  -61.840  1.00 103.91 ? 1498 ASP D N   1 
ATOM   7687 C CA  . ASP F 3 154 ? -24.446 45.870  -61.164  1.00 113.73 ? 1498 ASP D CA  1 
ATOM   7688 C C   . ASP F 3 154 ? -25.166 44.584  -60.781  1.00 113.48 ? 1498 ASP D C   1 
ATOM   7689 O O   . ASP F 3 154 ? -24.700 43.480  -61.088  1.00 103.27 ? 1498 ASP D O   1 
ATOM   7690 C CB  . ASP F 3 154 ? -23.846 46.519  -59.914  1.00 114.92 ? 1498 ASP D CB  1 
ATOM   7691 C CG  . ASP F 3 154 ? -22.560 47.267  -60.198  1.00 125.82 ? 1498 ASP D CG  1 
ATOM   7692 O OD1 . ASP F 3 154 ? -22.084 47.226  -61.351  1.00 126.35 ? 1498 ASP D OD1 1 
ATOM   7693 O OD2 . ASP F 3 154 ? -22.013 47.877  -59.256  1.00 138.63 ? 1498 ASP D OD2 1 
ATOM   7694 N N   . ASN F 3 155 ? -26.304 44.707  -60.105  1.00 111.27 ? 1499 ASN D N   1 
ATOM   7695 C CA  . ASN F 3 155 ? -26.941 43.581  -59.439  1.00 108.75 ? 1499 ASN D CA  1 
ATOM   7696 C C   . ASN F 3 155 ? -28.149 43.040  -60.195  1.00 103.49 ? 1499 ASN D C   1 
ATOM   7697 O O   . ASN F 3 155 ? -28.886 42.216  -59.646  1.00 108.65 ? 1499 ASN D O   1 
ATOM   7698 C CB  . ASN F 3 155 ? -27.348 43.987  -58.020  1.00 101.48 ? 1499 ASN D CB  1 
ATOM   7699 C CG  . ASN F 3 155 ? -26.164 44.440  -57.182  1.00 100.17 ? 1499 ASN D CG  1 
ATOM   7700 O OD1 . ASN F 3 155 ? -25.208 43.691  -56.979  1.00 94.62  ? 1499 ASN D OD1 1 
ATOM   7701 N ND2 . ASN F 3 155 ? -26.220 45.677  -56.700  1.00 96.60  ? 1499 ASN D ND2 1 
ATOM   7702 N N   . CYS F 3 156 ? -28.371 43.472  -61.440  1.00 101.14 ? 1500 CYS D N   1 
ATOM   7703 C CA  . CYS F 3 156 ? -29.500 42.933  -62.194  1.00 102.68 ? 1500 CYS D CA  1 
ATOM   7704 C C   . CYS F 3 156 ? -29.219 41.516  -62.672  1.00 105.70 ? 1500 CYS D C   1 
ATOM   7705 O O   . CYS F 3 156 ? -30.127 40.674  -62.693  1.00 107.62 ? 1500 CYS D O   1 
ATOM   7706 C CB  . CYS F 3 156 ? -29.838 43.827  -63.383  1.00 94.09  ? 1500 CYS D CB  1 
ATOM   7707 S SG  . CYS F 3 156 ? -30.959 43.033  -64.564  1.00 93.20  ? 1500 CYS D SG  1 
ATOM   7708 N N   . GLU F 3 157 ? -27.976 41.238  -63.079  1.00 84.49  ? 1501 GLU D N   1 
ATOM   7709 C CA  . GLU F 3 157 ? -27.606 39.876  -63.453  1.00 76.16  ? 1501 GLU D CA  1 
ATOM   7710 C C   . GLU F 3 157 ? -27.970 38.898  -62.344  1.00 94.78  ? 1501 GLU D C   1 
ATOM   7711 O O   . GLU F 3 157 ? -28.575 37.851  -62.594  1.00 101.69 ? 1501 GLU D O   1 
ATOM   7712 C CB  . GLU F 3 157 ? -26.111 39.801  -63.772  1.00 71.04  ? 1501 GLU D CB  1 
ATOM   7713 C CG  . GLU F 3 157 ? -25.500 38.420  -63.546  1.00 87.17  ? 1501 GLU D CG  1 
ATOM   7714 C CD  . GLU F 3 157 ? -24.333 38.129  -64.471  1.00 90.71  ? 1501 GLU D CD  1 
ATOM   7715 O OE1 . GLU F 3 157 ? -23.869 39.062  -65.160  1.00 105.64 ? 1501 GLU D OE1 1 
ATOM   7716 O OE2 . GLU F 3 157 ? -23.886 36.964  -64.516  1.00 79.04  ? 1501 GLU D OE2 1 
ATOM   7717 N N   . LEU F 3 158 ? -27.628 39.242  -61.101  1.00 93.93  ? 1502 LEU D N   1 
ATOM   7718 C CA  . LEU F 3 158 ? -28.058 38.434  -59.966  1.00 89.85  ? 1502 LEU D CA  1 
ATOM   7719 C C   . LEU F 3 158 ? -29.574 38.454  -59.817  1.00 82.17  ? 1502 LEU D C   1 
ATOM   7720 O O   . LEU F 3 158 ? -30.190 37.423  -59.519  1.00 92.64  ? 1502 LEU D O   1 
ATOM   7721 C CB  . LEU F 3 158 ? -27.393 38.937  -58.685  1.00 93.24  ? 1502 LEU D CB  1 
ATOM   7722 C CG  . LEU F 3 158 ? -27.877 38.275  -57.394  1.00 93.80  ? 1502 LEU D CG  1 
ATOM   7723 C CD1 . LEU F 3 158 ? -27.390 36.834  -57.313  1.00 93.09  ? 1502 LEU D CD1 1 
ATOM   7724 C CD2 . LEU F 3 158 ? -27.448 39.080  -56.174  1.00 91.07  ? 1502 LEU D CD2 1 
ATOM   7725 N N   . ALA F 3 159 ? -30.193 39.618  -60.030  1.00 66.72  ? 1503 ALA D N   1 
ATOM   7726 C CA  . ALA F 3 159 ? -31.623 39.765  -59.771  1.00 68.95  ? 1503 ALA D CA  1 
ATOM   7727 C C   . ALA F 3 159 ? -32.457 38.896  -60.704  1.00 85.68  ? 1503 ALA D C   1 
ATOM   7728 O O   . ALA F 3 159 ? -33.485 38.346  -60.291  1.00 92.82  ? 1503 ALA D O   1 
ATOM   7729 C CB  . ALA F 3 159 ? -32.028 41.233  -59.894  1.00 78.01  ? 1503 ALA D CB  1 
ATOM   7730 N N   . CYS F 3 160 ? -32.042 38.761  -61.963  1.00 90.07  ? 1504 CYS D N   1 
ATOM   7731 C CA  . CYS F 3 160 ? -32.760 37.883  -62.877  1.00 82.09  ? 1504 CYS D CA  1 
ATOM   7732 C C   . CYS F 3 160 ? -32.283 36.440  -62.806  1.00 76.08  ? 1504 CYS D C   1 
ATOM   7733 O O   . CYS F 3 160 ? -33.079 35.526  -63.050  1.00 83.51  ? 1504 CYS D O   1 
ATOM   7734 C CB  . CYS F 3 160 ? -32.647 38.383  -64.317  1.00 85.39  ? 1504 CYS D CB  1 
ATOM   7735 S SG  . CYS F 3 160 ? -33.729 37.467  -65.438  1.00 122.90 ? 1504 CYS D SG  1 
ATOM   7736 N N   . CYS F 3 161 ? -31.005 36.209  -62.485  1.00 71.12  ? 1505 CYS D N   1 
ATOM   7737 C CA  . CYS F 3 161 ? -30.560 34.850  -62.187  1.00 74.27  ? 1505 CYS D CA  1 
ATOM   7738 C C   . CYS F 3 161 ? -31.423 34.223  -61.102  1.00 81.67  ? 1505 CYS D C   1 
ATOM   7739 O O   . CYS F 3 161 ? -31.623 33.002  -61.087  1.00 79.22  ? 1505 CYS D O   1 
ATOM   7740 C CB  . CYS F 3 161 ? -29.091 34.853  -61.753  1.00 76.74  ? 1505 CYS D CB  1 
ATOM   7741 S SG  . CYS F 3 161 ? -27.879 34.866  -63.100  1.00 77.94  ? 1505 CYS D SG  1 
ATOM   7742 N N   . PHE F 3 162 ? -31.947 35.047  -60.192  1.00 77.14  ? 1506 PHE D N   1 
ATOM   7743 C CA  . PHE F 3 162 ? -32.877 34.571  -59.175  1.00 66.01  ? 1506 PHE D CA  1 
ATOM   7744 C C   . PHE F 3 162 ? -34.194 34.127  -59.800  1.00 65.21  ? 1506 PHE D C   1 
ATOM   7745 O O   . PHE F 3 162 ? -34.675 33.019  -59.537  1.00 84.43  ? 1506 PHE D O   1 
ATOM   7746 C CB  . PHE F 3 162 ? -33.118 35.676  -58.148  1.00 76.10  ? 1506 PHE D CB  1 
ATOM   7747 C CG  . PHE F 3 162 ? -33.627 35.183  -56.829  1.00 80.39  ? 1506 PHE D CG  1 
ATOM   7748 C CD1 . PHE F 3 162 ? -32.773 34.567  -55.931  1.00 81.28  ? 1506 PHE D CD1 1 
ATOM   7749 C CD2 . PHE F 3 162 ? -34.956 35.350  -56.478  1.00 73.84  ? 1506 PHE D CD2 1 
ATOM   7750 C CE1 . PHE F 3 162 ? -33.236 34.121  -54.712  1.00 84.35  ? 1506 PHE D CE1 1 
ATOM   7751 C CE2 . PHE F 3 162 ? -35.426 34.905  -55.258  1.00 74.06  ? 1506 PHE D CE2 1 
ATOM   7752 C CZ  . PHE F 3 162 ? -34.563 34.290  -54.373  1.00 78.46  ? 1506 PHE D CZ  1 
ATOM   7753 N N   . ILE F 3 163 ? -34.794 34.986  -60.629  1.00 52.53  ? 1507 ILE D N   1 
ATOM   7754 C CA  . ILE F 3 163 ? -36.059 34.639  -61.269  1.00 56.95  ? 1507 ILE D CA  1 
ATOM   7755 C C   . ILE F 3 163 ? -35.872 33.499  -62.263  1.00 52.33  ? 1507 ILE D C   1 
ATOM   7756 O O   . ILE F 3 163 ? -36.795 32.705  -62.488  1.00 46.49  ? 1507 ILE D O   1 
ATOM   7757 C CB  . ILE F 3 163 ? -36.674 35.884  -61.936  1.00 59.43  ? 1507 ILE D CB  1 
ATOM   7758 C CG1 . ILE F 3 163 ? -36.554 37.100  -61.013  1.00 62.15  ? 1507 ILE D CG1 1 
ATOM   7759 C CG2 . ILE F 3 163 ? -38.124 35.635  -62.308  1.00 52.10  ? 1507 ILE D CG2 1 
ATOM   7760 C CD1 . ILE F 3 163 ? -36.910 38.411  -61.677  1.00 53.79  ? 1507 ILE D CD1 1 
ATOM   7761 N N   . GLN F 3 164 ? -34.685 33.389  -62.867  1.00 59.41  ? 1508 GLN D N   1 
ATOM   7762 C CA  . GLN F 3 164 ? -34.412 32.285  -63.784  1.00 41.49  ? 1508 GLN D CA  1 
ATOM   7763 C C   . GLN F 3 164 ? -34.436 30.949  -63.054  1.00 52.15  ? 1508 GLN D C   1 
ATOM   7764 O O   . GLN F 3 164 ? -35.110 30.005  -63.482  1.00 55.45  ? 1508 GLN D O   1 
ATOM   7765 C CB  . GLN F 3 164 ? -33.061 32.494  -64.468  1.00 35.54  ? 1508 GLN D CB  1 
ATOM   7766 C CG  . GLN F 3 164 ? -33.102 33.402  -65.682  1.00 48.75  ? 1508 GLN D CG  1 
ATOM   7767 C CD  . GLN F 3 164 ? -31.795 33.400  -66.453  1.00 59.98  ? 1508 GLN D CD  1 
ATOM   7768 O OE1 . GLN F 3 164 ? -30.761 33.833  -65.945  1.00 69.98  ? 1508 GLN D OE1 1 
ATOM   7769 N NE2 . GLN F 3 164 ? -31.836 32.913  -67.687  1.00 59.54  ? 1508 GLN D NE2 1 
ATOM   7770 N N   . LYS F 3 165 ? -33.699 30.853  -61.945  1.00 63.96  ? 1509 LYS D N   1 
ATOM   7771 C CA  . LYS F 3 165 ? -33.657 29.609  -61.185  1.00 61.97  ? 1509 LYS D CA  1 
ATOM   7772 C C   . LYS F 3 165 ? -35.029 29.237  -60.635  1.00 68.02  ? 1509 LYS D C   1 
ATOM   7773 O O   . LYS F 3 165 ? -35.355 28.048  -60.544  1.00 75.72  ? 1509 LYS D O   1 
ATOM   7774 C CB  . LYS F 3 165 ? -32.637 29.728  -60.053  1.00 59.17  ? 1509 LYS D CB  1 
ATOM   7775 C CG  . LYS F 3 165 ? -32.438 28.457  -59.249  1.00 74.12  ? 1509 LYS D CG  1 
ATOM   7776 C CD  . LYS F 3 165 ? -31.134 28.509  -58.467  1.00 82.53  ? 1509 LYS D CD  1 
ATOM   7777 C CE  . LYS F 3 165 ? -30.940 27.259  -57.629  1.00 80.23  ? 1509 LYS D CE  1 
ATOM   7778 N NZ  . LYS F 3 165 ? -29.522 27.105  -57.203  1.00 79.72  ? 1509 LYS D NZ  1 
ATOM   7779 N N   . THR F 3 166 ? -35.846 30.232  -60.271  1.00 61.18  ? 1510 THR D N   1 
ATOM   7780 C CA  . THR F 3 166 ? -37.196 29.944  -59.791  1.00 54.99  ? 1510 THR D CA  1 
ATOM   7781 C C   . THR F 3 166 ? -38.020 29.235  -60.858  1.00 64.56  ? 1510 THR D C   1 
ATOM   7782 O O   . THR F 3 166 ? -38.713 28.252  -60.568  1.00 68.10  ? 1510 THR D O   1 
ATOM   7783 C CB  . THR F 3 166 ? -37.899 31.233  -59.358  1.00 57.77  ? 1510 THR D CB  1 
ATOM   7784 O OG1 . THR F 3 166 ? -36.962 32.112  -58.725  1.00 59.80  ? 1510 THR D OG1 1 
ATOM   7785 C CG2 . THR F 3 166 ? -39.033 30.922  -58.387  1.00 66.93  ? 1510 THR D CG2 1 
ATOM   7786 N N   . ALA F 3 167 ? -37.953 29.720  -62.101  1.00 66.34  ? 1511 ALA D N   1 
ATOM   7787 C CA  . ALA F 3 167 ? -38.735 29.120  -63.177  1.00 56.32  ? 1511 ALA D CA  1 
ATOM   7788 C C   . ALA F 3 167 ? -38.253 27.711  -63.498  1.00 52.33  ? 1511 ALA D C   1 
ATOM   7789 O O   . ALA F 3 167 ? -39.064 26.830  -63.804  1.00 63.17  ? 1511 ALA D O   1 
ATOM   7790 C CB  . ALA F 3 167 ? -38.678 30.004  -64.422  1.00 50.06  ? 1511 ALA D CB  1 
ATOM   7791 N N   . VAL F 3 168 ? -36.940 27.476  -63.435  1.00 43.02  ? 1512 VAL D N   1 
ATOM   7792 C CA  . VAL F 3 168 ? -36.419 26.143  -63.727  1.00 43.41  ? 1512 VAL D CA  1 
ATOM   7793 C C   . VAL F 3 168 ? -36.823 25.156  -62.639  1.00 62.73  ? 1512 VAL D C   1 
ATOM   7794 O O   . VAL F 3 168 ? -37.129 23.990  -62.920  1.00 67.96  ? 1512 VAL D O   1 
ATOM   7795 C CB  . VAL F 3 168 ? -34.893 26.184  -63.906  1.00 49.49  ? 1512 VAL D CB  1 
ATOM   7796 C CG1 . VAL F 3 168 ? -34.387 24.801  -64.253  1.00 50.06  ? 1512 VAL D CG1 1 
ATOM   7797 C CG2 . VAL F 3 168 ? -34.511 27.181  -64.986  1.00 49.37  ? 1512 VAL D CG2 1 
ATOM   7798 N N   . GLU F 3 169 ? -36.824 25.599  -61.379  1.00 64.75  ? 1513 GLU D N   1 
ATOM   7799 C CA  . GLU F 3 169 ? -37.252 24.731  -60.289  1.00 63.23  ? 1513 GLU D CA  1 
ATOM   7800 C C   . GLU F 3 169 ? -38.752 24.463  -60.322  1.00 54.66  ? 1513 GLU D C   1 
ATOM   7801 O O   . GLU F 3 169 ? -39.196 23.436  -59.798  1.00 58.49  ? 1513 GLU D O   1 
ATOM   7802 C CB  . GLU F 3 169 ? -36.847 25.338  -58.945  1.00 53.50  ? 1513 GLU D CB  1 
ATOM   7803 C CG  . GLU F 3 169 ? -35.338 25.438  -58.743  1.00 43.34  ? 1513 GLU D CG  1 
ATOM   7804 C CD  . GLU F 3 169 ? -34.681 24.084  -58.550  1.00 61.92  ? 1513 GLU D CD  1 
ATOM   7805 O OE1 . GLU F 3 169 ? -34.694 23.569  -57.411  1.00 78.08  ? 1513 GLU D OE1 1 
ATOM   7806 O OE2 . GLU F 3 169 ? -34.158 23.533  -59.542  1.00 56.44  ? 1513 GLU D OE2 1 
ATOM   7807 N N   . LYS F 3 170 ? -39.535 25.356  -60.929  1.00 38.49  ? 1514 LYS D N   1 
ATOM   7808 C CA  . LYS F 3 170 ? -40.956 25.123  -61.150  1.00 30.31  ? 1514 LYS D CA  1 
ATOM   7809 C C   . LYS F 3 170 ? -41.236 24.412  -62.468  1.00 42.49  ? 1514 LYS D C   1 
ATOM   7810 O O   . LYS F 3 170 ? -42.322 23.845  -62.634  1.00 41.03  ? 1514 LYS D O   1 
ATOM   7811 C CB  . LYS F 3 170 ? -41.722 26.453  -61.115  1.00 33.27  ? 1514 LYS D CB  1 
ATOM   7812 C CG  . LYS F 3 170 ? -43.238 26.318  -61.003  1.00 44.03  ? 1514 LYS D CG  1 
ATOM   7813 C CD  . LYS F 3 170 ? -43.867 27.550  -60.367  1.00 38.54  ? 1514 LYS D CD  1 
ATOM   7814 C CE  . LYS F 3 170 ? -45.279 27.783  -60.888  1.00 67.85  ? 1514 LYS D CE  1 
ATOM   7815 N NZ  . LYS F 3 170 ? -46.260 26.805  -60.335  1.00 67.38  ? 1514 LYS D NZ  1 
ATOM   7816 N N   . ALA F 3 171 ? -40.280 24.420  -63.401  1.00 52.33  ? 1515 ALA D N   1 
ATOM   7817 C CA  . ALA F 3 171 ? -40.493 23.777  -64.693  1.00 45.48  ? 1515 ALA D CA  1 
ATOM   7818 C C   . ALA F 3 171 ? -40.478 22.259  -64.583  1.00 56.71  ? 1515 ALA D C   1 
ATOM   7819 O O   . ALA F 3 171 ? -41.148 21.578  -65.368  1.00 74.44  ? 1515 ALA D O   1 
ATOM   7820 C CB  . ALA F 3 171 ? -39.434 24.241  -65.694  1.00 45.59  ? 1515 ALA D CB  1 
ATOM   7821 N N   . GLY F 3 172 ? -39.723 21.714  -63.631  1.00 53.38  ? 1516 GLY D N   1 
ATOM   7822 C CA  . GLY F 3 172 ? -39.638 20.286  -63.431  1.00 54.36  ? 1516 GLY D CA  1 
ATOM   7823 C C   . GLY F 3 172 ? -40.984 19.612  -63.230  1.00 48.75  ? 1516 GLY D C   1 
ATOM   7824 O O   . GLY F 3 172 ? -41.384 18.736  -64.004  1.00 57.72  ? 1516 GLY D O   1 
ATOM   7825 N N   . PRO F 3 173 ? -41.706 20.001  -62.174  1.00 47.01  ? 1517 PRO D N   1 
ATOM   7826 C CA  . PRO F 3 173 ? -43.021 19.381  -61.926  1.00 46.75  ? 1517 PRO D CA  1 
ATOM   7827 C C   . PRO F 3 173 ? -44.012 19.559  -63.066  1.00 53.60  ? 1517 PRO D C   1 
ATOM   7828 O O   . PRO F 3 173 ? -44.801 18.646  -63.341  1.00 49.41  ? 1517 PRO D O   1 
ATOM   7829 C CB  . PRO F 3 173 ? -43.495 20.083  -60.646  1.00 43.92  ? 1517 PRO D CB  1 
ATOM   7830 C CG  . PRO F 3 173 ? -42.237 20.504  -59.965  1.00 45.61  ? 1517 PRO D CG  1 
ATOM   7831 C CD  . PRO F 3 173 ? -41.293 20.880  -61.065  1.00 54.72  ? 1517 PRO D CD  1 
ATOM   7832 N N   . GLU F 3 174 ? -43.999 20.713  -63.739  1.00 58.82  ? 1518 GLU D N   1 
ATOM   7833 C CA  . GLU F 3 174 ? -44.946 20.938  -64.827  1.00 45.62  ? 1518 GLU D CA  1 
ATOM   7834 C C   . GLU F 3 174 ? -44.605 20.086  -66.041  1.00 55.84  ? 1518 GLU D C   1 
ATOM   7835 O O   . GLU F 3 174 ? -45.503 19.612  -66.747  1.00 65.93  ? 1518 GLU D O   1 
ATOM   7836 C CB  . GLU F 3 174 ? -44.980 22.420  -65.201  1.00 47.82  ? 1518 GLU D CB  1 
ATOM   7837 C CG  . GLU F 3 174 ? -45.378 23.344  -64.059  1.00 52.63  ? 1518 GLU D CG  1 
ATOM   7838 C CD  . GLU F 3 174 ? -46.861 23.668  -64.064  1.00 75.43  ? 1518 GLU D CD  1 
ATOM   7839 O OE1 . GLU F 3 174 ? -47.540 23.323  -65.058  1.00 60.48  ? 1518 GLU D OE1 1 
ATOM   7840 O OE2 . GLU F 3 174 ? -47.346 24.264  -63.076  1.00 67.34  ? 1518 GLU D OE2 1 
ATOM   7841 N N   . MET F 3 175 ? -43.312 19.881  -66.303  1.00 52.75  ? 1519 MET D N   1 
ATOM   7842 C CA  . MET F 3 175 ? -42.914 19.016  -67.409  1.00 53.11  ? 1519 MET D CA  1 
ATOM   7843 C C   . MET F 3 175 ? -43.275 17.564  -67.127  1.00 56.47  ? 1519 MET D C   1 
ATOM   7844 O O   . MET F 3 175 ? -43.732 16.846  -68.025  1.00 65.23  ? 1519 MET D O   1 
ATOM   7845 C CB  . MET F 3 175 ? -41.415 19.156  -67.674  1.00 57.55  ? 1519 MET D CB  1 
ATOM   7846 C CG  . MET F 3 175 ? -40.913 18.344  -68.857  1.00 58.69  ? 1519 MET D CG  1 
ATOM   7847 S SD  . MET F 3 175 ? -40.826 19.300  -70.385  1.00 67.46  ? 1519 MET D SD  1 
ATOM   7848 C CE  . MET F 3 175 ? -42.492 19.113  -71.018  1.00 49.70  ? 1519 MET D CE  1 
ATOM   7849 N N   . ASP F 3 176 ? -43.080 17.114  -65.884  1.00 57.38  ? 1520 ASP D N   1 
ATOM   7850 C CA  . ASP F 3 176 ? -43.470 15.760  -65.505  1.00 58.01  ? 1520 ASP D CA  1 
ATOM   7851 C C   . ASP F 3 176 ? -44.964 15.526  -65.674  1.00 66.04  ? 1520 ASP D C   1 
ATOM   7852 O O   . ASP F 3 176 ? -45.391 14.372  -65.793  1.00 63.69  ? 1520 ASP D O   1 
ATOM   7853 C CB  . ASP F 3 176 ? -43.066 15.480  -64.054  1.00 59.71  ? 1520 ASP D CB  1 
ATOM   7854 C CG  . ASP F 3 176 ? -41.584 15.186  -63.902  1.00 57.77  ? 1520 ASP D CG  1 
ATOM   7855 O OD1 . ASP F 3 176 ? -40.954 14.760  -64.893  1.00 58.93  ? 1520 ASP D OD1 1 
ATOM   7856 O OD2 . ASP F 3 176 ? -41.049 15.381  -62.788  1.00 48.67  ? 1520 ASP D OD2 1 
ATOM   7857 N N   . LYS F 3 177 ? -45.767 16.592  -65.688  1.00 64.39  ? 1521 LYS D N   1 
ATOM   7858 C CA  . LYS F 3 177 ? -47.210 16.446  -65.834  1.00 58.64  ? 1521 LYS D CA  1 
ATOM   7859 C C   . LYS F 3 177 ? -47.609 16.134  -67.271  1.00 66.44  ? 1521 LYS D C   1 
ATOM   7860 O O   . LYS F 3 177 ? -48.460 15.270  -67.505  1.00 85.27  ? 1521 LYS D O   1 
ATOM   7861 C CB  . LYS F 3 177 ? -47.919 17.713  -65.356  1.00 46.52  ? 1521 LYS D CB  1 
ATOM   7862 C CG  . LYS F 3 177 ? -49.412 17.531  -65.133  1.00 46.84  ? 1521 LYS D CG  1 
ATOM   7863 C CD  . LYS F 3 177 ? -50.124 18.863  -64.955  1.00 34.12  ? 1521 LYS D CD  1 
ATOM   7864 C CE  . LYS F 3 177 ? -49.609 19.914  -65.929  1.00 56.65  ? 1521 LYS D CE  1 
ATOM   7865 N NZ  . LYS F 3 177 ? -50.208 21.252  -65.668  1.00 57.00  ? 1521 LYS D NZ  1 
ATOM   7866 N N   . ARG F 3 178 ? -47.014 16.824  -68.245  1.00 55.08  ? 1522 ARG D N   1 
ATOM   7867 C CA  . ARG F 3 178 ? -47.446 16.662  -69.630  1.00 60.29  ? 1522 ARG D CA  1 
ATOM   7868 C C   . ARG F 3 178 ? -46.774 15.480  -70.311  1.00 64.40  ? 1522 ARG D C   1 
ATOM   7869 O O   . ARG F 3 178 ? -47.337 14.912  -71.254  1.00 69.00  ? 1522 ARG D O   1 
ATOM   7870 C CB  . ARG F 3 178 ? -47.189 17.951  -70.400  1.00 48.15  ? 1522 ARG D CB  1 
ATOM   7871 C CG  . ARG F 3 178 ? -47.675 19.159  -69.636  1.00 69.00  ? 1522 ARG D CG  1 
ATOM   7872 C CD  . ARG F 3 178 ? -48.725 19.933  -70.411  1.00 74.12  ? 1522 ARG D CD  1 
ATOM   7873 N NE  . ARG F 3 178 ? -48.250 20.305  -71.739  1.00 72.94  ? 1522 ARG D NE  1 
ATOM   7874 C CZ  . ARG F 3 178 ? -48.928 21.059  -72.593  1.00 90.95  ? 1522 ARG D CZ  1 
ATOM   7875 N NH1 . ARG F 3 178 ? -50.115 21.555  -72.284  1.00 92.16  ? 1522 ARG D NH1 1 
ATOM   7876 N NH2 . ARG F 3 178 ? -48.402 21.323  -73.786  1.00 79.90  ? 1522 ARG D NH2 1 
ATOM   7877 N N   . LEU F 3 179 ? -45.585 15.098  -69.856  1.00 55.06  ? 1523 LEU D N   1 
ATOM   7878 C CA  . LEU F 3 179 ? -44.980 13.853  -70.303  1.00 52.29  ? 1523 LEU D CA  1 
ATOM   7879 C C   . LEU F 3 179 ? -45.483 12.649  -69.522  1.00 62.59  ? 1523 LEU D C   1 
ATOM   7880 O O   . LEU F 3 179 ? -45.051 11.527  -69.805  1.00 70.73  ? 1523 LEU D O   1 
ATOM   7881 C CB  . LEU F 3 179 ? -43.457 13.940  -70.199  1.00 39.58  ? 1523 LEU D CB  1 
ATOM   7882 C CG  . LEU F 3 179 ? -42.794 14.777  -71.294  1.00 55.47  ? 1523 LEU D CG  1 
ATOM   7883 C CD1 . LEU F 3 179 ? -41.297 14.806  -71.087  1.00 61.19  ? 1523 LEU D CD1 1 
ATOM   7884 C CD2 . LEU F 3 179 ? -43.143 14.251  -72.684  1.00 21.92  ? 1523 LEU D CD2 1 
ATOM   7885 N N   . ALA F 3 180 ? -46.379 12.854  -68.550  1.00 63.08  ? 1524 ALA D N   1 
ATOM   7886 C CA  . ALA F 3 180 ? -46.927 11.727  -67.803  1.00 60.08  ? 1524 ALA D CA  1 
ATOM   7887 C C   . ALA F 3 180 ? -47.630 10.744  -68.724  1.00 56.24  ? 1524 ALA D C   1 
ATOM   7888 O O   . ALA F 3 180 ? -47.696 9.547   -68.419  1.00 62.62  ? 1524 ALA D O   1 
ATOM   7889 C CB  . ALA F 3 180 ? -47.883 12.223  -66.718  1.00 75.45  ? 1524 ALA D CB  1 
ATOM   7890 N N   . THR F 3 181 ? -48.157 11.224  -69.852  1.00 60.02  ? 1525 THR D N   1 
ATOM   7891 C CA  . THR F 3 181 ? -48.661 10.317  -70.875  1.00 64.80  ? 1525 THR D CA  1 
ATOM   7892 C C   . THR F 3 181 ? -47.527 9.474   -71.444  1.00 71.00  ? 1525 THR D C   1 
ATOM   7893 O O   . THR F 3 181 ? -47.543 8.241   -71.350  1.00 67.82  ? 1525 THR D O   1 
ATOM   7894 C CB  . THR F 3 181 ? -49.360 11.107  -71.985  1.00 56.30  ? 1525 THR D CB  1 
ATOM   7895 O OG1 . THR F 3 181 ? -50.693 11.433  -71.575  1.00 52.23  ? 1525 THR D OG1 1 
ATOM   7896 C CG2 . THR F 3 181 ? -49.431 10.286  -73.267  1.00 46.17  ? 1525 THR D CG2 1 
ATOM   7897 N N   . GLU F 3 182 ? -46.508 10.134  -72.006  1.00 70.71  ? 1526 GLU D N   1 
ATOM   7898 C CA  . GLU F 3 182 ? -45.423 9.417   -72.670  1.00 61.43  ? 1526 GLU D CA  1 
ATOM   7899 C C   . GLU F 3 182 ? -44.633 8.554   -71.697  1.00 63.21  ? 1526 GLU D C   1 
ATOM   7900 O O   . GLU F 3 182 ? -44.109 7.504   -72.085  1.00 71.14  ? 1526 GLU D O   1 
ATOM   7901 C CB  . GLU F 3 182 ? -44.496 10.406  -73.377  1.00 58.48  ? 1526 GLU D CB  1 
ATOM   7902 C CG  . GLU F 3 182 ? -45.208 11.339  -74.342  1.00 63.53  ? 1526 GLU D CG  1 
ATOM   7903 C CD  . GLU F 3 182 ? -45.699 10.623  -75.586  1.00 74.56  ? 1526 GLU D CD  1 
ATOM   7904 O OE1 . GLU F 3 182 ? -45.093 9.596   -75.964  1.00 61.93  ? 1526 GLU D OE1 1 
ATOM   7905 O OE2 . GLU F 3 182 ? -46.692 11.087  -76.186  1.00 75.81  ? 1526 GLU D OE2 1 
ATOM   7906 N N   . PHE F 3 183 ? -44.538 8.972   -70.433  1.00 72.00  ? 1527 PHE D N   1 
ATOM   7907 C CA  . PHE F 3 183 ? -43.822 8.181   -69.439  1.00 66.15  ? 1527 PHE D CA  1 
ATOM   7908 C C   . PHE F 3 183 ? -44.535 6.878   -69.113  1.00 77.68  ? 1527 PHE D C   1 
ATOM   7909 O O   . PHE F 3 183 ? -43.909 5.959   -68.574  1.00 81.09  ? 1527 PHE D O   1 
ATOM   7910 C CB  . PHE F 3 183 ? -43.631 8.993   -68.160  1.00 42.12  ? 1527 PHE D CB  1 
ATOM   7911 C CG  . PHE F 3 183 ? -42.608 10.078  -68.283  1.00 56.54  ? 1527 PHE D CG  1 
ATOM   7912 C CD1 . PHE F 3 183 ? -41.742 10.109  -69.365  1.00 76.55  ? 1527 PHE D CD1 1 
ATOM   7913 C CD2 . PHE F 3 183 ? -42.512 11.071  -67.325  1.00 60.85  ? 1527 PHE D CD2 1 
ATOM   7914 C CE1 . PHE F 3 183 ? -40.799 11.109  -69.487  1.00 78.46  ? 1527 PHE D CE1 1 
ATOM   7915 C CE2 . PHE F 3 183 ? -41.570 12.074  -67.440  1.00 72.04  ? 1527 PHE D CE2 1 
ATOM   7916 C CZ  . PHE F 3 183 ? -40.713 12.093  -68.523  1.00 82.40  ? 1527 PHE D CZ  1 
ATOM   7917 N N   . GLU F 3 184 ? -45.824 6.780   -69.428  1.00 67.73  ? 1528 GLU D N   1 
ATOM   7918 C CA  . GLU F 3 184 ? -46.605 5.601   -69.086  1.00 64.72  ? 1528 GLU D CA  1 
ATOM   7919 C C   . GLU F 3 184 ? -46.518 4.517   -70.157  1.00 77.96  ? 1528 GLU D C   1 
ATOM   7920 O O   . GLU F 3 184 ? -46.285 3.348   -69.834  1.00 89.58  ? 1528 GLU D O   1 
ATOM   7921 C CB  . GLU F 3 184 ? -48.064 5.989   -68.848  1.00 74.18  ? 1528 GLU D CB  1 
ATOM   7922 C CG  . GLU F 3 184 ? -49.034 4.951   -69.371  1.00 93.19  ? 1528 GLU D CG  1 
ATOM   7923 C CD  . GLU F 3 184 ? -50.439 5.140   -68.879  1.00 90.16  ? 1528 GLU D CD  1 
ATOM   7924 O OE1 . GLU F 3 184 ? -50.946 6.277   -68.915  1.00 80.27  ? 1528 GLU D OE1 1 
ATOM   7925 O OE2 . GLU F 3 184 ? -51.026 4.132   -68.444  1.00 80.38  ? 1528 GLU D OE2 1 
ATOM   7926 N N   . LEU F 3 185 ? -46.695 4.885   -71.433  1.00 70.82  ? 1529 LEU D N   1 
ATOM   7927 C CA  . LEU F 3 185 ? -46.723 3.876   -72.487  1.00 60.59  ? 1529 LEU D CA  1 
ATOM   7928 C C   . LEU F 3 185 ? -45.424 3.088   -72.560  1.00 67.34  ? 1529 LEU D C   1 
ATOM   7929 O O   . LEU F 3 185 ? -45.420 1.976   -73.096  1.00 77.88  ? 1529 LEU D O   1 
ATOM   7930 C CB  . LEU F 3 185 ? -47.017 4.508   -73.849  1.00 58.57  ? 1529 LEU D CB  1 
ATOM   7931 C CG  . LEU F 3 185 ? -48.116 5.559   -74.009  1.00 60.61  ? 1529 LEU D CG  1 
ATOM   7932 C CD1 . LEU F 3 185 ? -47.509 6.935   -74.132  1.00 69.14  ? 1529 LEU D CD1 1 
ATOM   7933 C CD2 . LEU F 3 185 ? -48.958 5.245   -75.233  1.00 71.92  ? 1529 LEU D CD2 1 
ATOM   7934 N N   . ARG F 3 186 ? -44.328 3.635   -72.033  1.00 58.12  ? 1530 ARG D N   1 
ATOM   7935 C CA  . ARG F 3 186 ? -43.074 2.900   -71.945  1.00 67.77  ? 1530 ARG D CA  1 
ATOM   7936 C C   . ARG F 3 186 ? -42.986 2.062   -70.681  1.00 72.54  ? 1530 ARG D C   1 
ATOM   7937 O O   . ARG F 3 186 ? -42.326 1.019   -70.685  1.00 85.91  ? 1530 ARG D O   1 
ATOM   7938 C CB  . ARG F 3 186 ? -41.897 3.876   -72.019  1.00 71.87  ? 1530 ARG D CB  1 
ATOM   7939 C CG  . ARG F 3 186 ? -42.166 5.024   -72.983  1.00 55.03  ? 1530 ARG D CG  1 
ATOM   7940 C CD  . ARG F 3 186 ? -40.919 5.813   -73.326  1.00 49.76  ? 1530 ARG D CD  1 
ATOM   7941 N NE  . ARG F 3 186 ? -40.909 6.224   -74.726  1.00 45.13  ? 1530 ARG D NE  1 
ATOM   7942 C CZ  . ARG F 3 186 ? -41.729 7.121   -75.259  1.00 50.52  ? 1530 ARG D CZ  1 
ATOM   7943 N NH1 . ARG F 3 186 ? -42.630 7.760   -74.530  1.00 55.03  ? 1530 ARG D NH1 1 
ATOM   7944 N NH2 . ARG F 3 186 ? -41.620 7.409   -76.553  1.00 53.08  ? 1530 ARG D NH2 1 
ATOM   7945 N N   . LYS F 3 187 ? -43.634 2.497   -69.600  1.00 88.15  ? 1531 LYS D N   1 
ATOM   7946 C CA  . LYS F 3 187 ? -43.786 1.627   -68.441  1.00 89.15  ? 1531 LYS D CA  1 
ATOM   7947 C C   . LYS F 3 187 ? -44.837 0.557   -68.704  1.00 83.40  ? 1531 LYS D C   1 
ATOM   7948 O O   . LYS F 3 187 ? -44.626 -0.619  -68.388  1.00 93.37  ? 1531 LYS D O   1 
ATOM   7949 C CB  . LYS F 3 187 ? -44.161 2.448   -67.209  1.00 87.05  ? 1531 LYS D CB  1 
ATOM   7950 C CG  . LYS F 3 187 ? -42.983 3.066   -66.474  1.00 85.32  ? 1531 LYS D CG  1 
ATOM   7951 C CD  . LYS F 3 187 ? -43.408 3.503   -65.083  1.00 84.70  ? 1531 LYS D CD  1 
ATOM   7952 C CE  . LYS F 3 187 ? -44.373 4.674   -65.141  1.00 73.64  ? 1531 LYS D CE  1 
ATOM   7953 N NZ  . LYS F 3 187 ? -43.936 5.789   -64.259  1.00 86.51  ? 1531 LYS D NZ  1 
ATOM   7954 N N   . HIS F 3 188 ? -45.970 0.948   -69.296  1.00 81.83  ? 1532 HIS D N   1 
ATOM   7955 C CA  . HIS F 3 188 ? -47.056 0.005   -69.544  1.00 89.34  ? 1532 HIS D CA  1 
ATOM   7956 C C   . HIS F 3 188 ? -46.651 -1.061  -70.555  1.00 93.51  ? 1532 HIS D C   1 
ATOM   7957 O O   . HIS F 3 188 ? -46.935 -2.248  -70.359  1.00 98.82  ? 1532 HIS D O   1 
ATOM   7958 C CB  . HIS F 3 188 ? -48.299 0.759   -70.021  1.00 93.49  ? 1532 HIS D CB  1 
ATOM   7959 C CG  . HIS F 3 188 ? -49.430 -0.132  -70.432  1.00 104.20 ? 1532 HIS D CG  1 
ATOM   7960 N ND1 . HIS F 3 188 ? -49.476 -0.764  -71.657  1.00 99.05  ? 1532 HIS D ND1 1 
ATOM   7961 C CD2 . HIS F 3 188 ? -50.560 -0.494  -69.781  1.00 108.22 ? 1532 HIS D CD2 1 
ATOM   7962 C CE1 . HIS F 3 188 ? -50.584 -1.478  -71.741  1.00 109.09 ? 1532 HIS D CE1 1 
ATOM   7963 N NE2 . HIS F 3 188 ? -51.260 -1.332  -70.615  1.00 117.48 ? 1532 HIS D NE2 1 
ATOM   7964 N N   . ALA F 3 189 ? -46.002 -0.657  -71.651  1.00 87.76  ? 1533 ALA D N   1 
ATOM   7965 C CA  . ALA F 3 189 ? -45.528 -1.638  -72.622  1.00 89.57  ? 1533 ALA D CA  1 
ATOM   7966 C C   . ALA F 3 189 ? -44.440 -2.525  -72.033  1.00 88.13  ? 1533 ALA D C   1 
ATOM   7967 O O   . ALA F 3 189 ? -44.324 -3.695  -72.413  1.00 99.30  ? 1533 ALA D O   1 
ATOM   7968 C CB  . ALA F 3 189 ? -45.020 -0.939  -73.881  1.00 84.58  ? 1533 ALA D CB  1 
ATOM   7969 N N   . ARG F 3 190 ? -43.639 -1.989  -71.108  1.00 80.13  ? 1534 ARG D N   1 
ATOM   7970 C CA  . ARG F 3 190 ? -42.611 -2.795  -70.458  1.00 85.15  ? 1534 ARG D CA  1 
ATOM   7971 C C   . ARG F 3 190 ? -43.221 -3.950  -69.673  1.00 95.31  ? 1534 ARG D C   1 
ATOM   7972 O O   . ARG F 3 190 ? -42.634 -5.037  -69.612  1.00 96.63  ? 1534 ARG D O   1 
ATOM   7973 C CB  . ARG F 3 190 ? -41.756 -1.909  -69.548  1.00 85.42  ? 1534 ARG D CB  1 
ATOM   7974 C CG  . ARG F 3 190 ? -41.096 -2.627  -68.383  1.00 85.65  ? 1534 ARG D CG  1 
ATOM   7975 C CD  . ARG F 3 190 ? -39.860 -1.880  -67.908  1.00 88.89  ? 1534 ARG D CD  1 
ATOM   7976 N NE  . ARG F 3 190 ? -39.909 -0.467  -68.267  1.00 90.59  ? 1534 ARG D NE  1 
ATOM   7977 C CZ  . ARG F 3 190 ? -38.847 0.262   -68.581  1.00 90.96  ? 1534 ARG D CZ  1 
ATOM   7978 N NH1 . ARG F 3 190 ? -37.629 -0.254  -68.579  1.00 87.75  ? 1534 ARG D NH1 1 
ATOM   7979 N NH2 . ARG F 3 190 ? -39.011 1.541   -68.905  1.00 78.22  ? 1534 ARG D NH2 1 
ATOM   7980 N N   . GLN F 3 191 ? -44.405 -3.744  -69.085  1.00 104.84 ? 1535 GLN D N   1 
ATOM   7981 C CA  . GLN F 3 191 ? -45.056 -4.815  -68.337  1.00 103.08 ? 1535 GLN D CA  1 
ATOM   7982 C C   . GLN F 3 191 ? -45.467 -5.969  -69.243  1.00 100.56 ? 1535 GLN D C   1 
ATOM   7983 O O   . GLN F 3 191 ? -45.548 -7.115  -68.787  1.00 110.74 ? 1535 GLN D O   1 
ATOM   7984 C CB  . GLN F 3 191 ? -46.275 -4.273  -67.586  1.00 98.97  ? 1535 GLN D CB  1 
ATOM   7985 C CG  . GLN F 3 191 ? -46.038 -2.961  -66.847  1.00 97.71  ? 1535 GLN D CG  1 
ATOM   7986 C CD  . GLN F 3 191 ? -45.048 -3.083  -65.698  1.00 104.20 ? 1535 GLN D CD  1 
ATOM   7987 O OE1 . GLN F 3 191 ? -44.645 -4.183  -65.316  1.00 116.06 ? 1535 GLN D OE1 1 
ATOM   7988 N NE2 . GLN F 3 191 ? -44.648 -1.945  -65.143  1.00 96.39  ? 1535 GLN D NE2 1 
ATOM   7989 N N   . GLU F 3 192 ? -45.728 -5.691  -70.519  1.00 94.25  ? 1536 GLU D N   1 
ATOM   7990 C CA  . GLU F 3 192 ? -46.070 -6.719  -71.489  1.00 97.00  ? 1536 GLU D CA  1 
ATOM   7991 C C   . GLU F 3 192 ? -44.846 -7.271  -72.213  1.00 100.07 ? 1536 GLU D C   1 
ATOM   7992 O O   . GLU F 3 192 ? -44.980 -7.817  -73.314  1.00 101.40 ? 1536 GLU D O   1 
ATOM   7993 C CB  . GLU F 3 192 ? -47.086 -6.174  -72.496  1.00 79.26  ? 1536 GLU D CB  1 
ATOM   7994 C CG  . GLU F 3 192 ? -48.179 -7.162  -72.875  1.00 93.33  ? 1536 GLU D CG  1 
ATOM   7995 C CD  . GLU F 3 192 ? -49.223 -7.358  -71.782  1.00 118.64 ? 1536 GLU D CD  1 
ATOM   7996 O OE1 . GLU F 3 192 ? -50.227 -8.052  -72.052  1.00 124.50 ? 1536 GLU D OE1 1 
ATOM   7997 O OE2 . GLU F 3 192 ? -49.059 -6.820  -70.667  1.00 121.10 ? 1536 GLU D OE2 1 
ATOM   7998 N N   . GLY F 3 193 ? -43.661 -7.137  -71.618  1.00 94.97  ? 1537 GLY D N   1 
ATOM   7999 C CA  . GLY F 3 193 ? -42.444 -7.645  -72.221  1.00 83.21  ? 1537 GLY D CA  1 
ATOM   8000 C C   . GLY F 3 193 ? -42.085 -7.015  -73.545  1.00 85.34  ? 1537 GLY D C   1 
ATOM   8001 O O   . GLY F 3 193 ? -41.286 -7.583  -74.294  1.00 93.45  ? 1537 GLY D O   1 
ATOM   8002 N N   . ARG F 3 194 ? -42.652 -5.854  -73.858  1.00 80.69  ? 1538 ARG D N   1 
ATOM   8003 C CA  . ARG F 3 194 ? -42.431 -5.190  -75.132  1.00 69.51  ? 1538 ARG D CA  1 
ATOM   8004 C C   . ARG F 3 194 ? -41.854 -3.798  -74.907  1.00 83.57  ? 1538 ARG D C   1 
ATOM   8005 O O   . ARG F 3 194 ? -42.021 -3.193  -73.844  1.00 99.70  ? 1538 ARG D O   1 
ATOM   8006 C CB  . ARG F 3 194 ? -43.734 -5.099  -75.944  1.00 73.49  ? 1538 ARG D CB  1 
ATOM   8007 C CG  . ARG F 3 194 ? -44.383 -3.723  -75.940  1.00 76.05  ? 1538 ARG D CG  1 
ATOM   8008 C CD  . ARG F 3 194 ? -45.658 -3.690  -76.768  1.00 76.29  ? 1538 ARG D CD  1 
ATOM   8009 N NE  . ARG F 3 194 ? -46.796 -4.241  -76.041  1.00 84.14  ? 1538 ARG D NE  1 
ATOM   8010 C CZ  . ARG F 3 194 ? -47.931 -4.625  -76.608  1.00 93.24  ? 1538 ARG D CZ  1 
ATOM   8011 N NH1 . ARG F 3 194 ? -48.119 -4.528  -77.915  1.00 95.37  ? 1538 ARG D NH1 1 
ATOM   8012 N NH2 . ARG F 3 194 ? -48.901 -5.121  -75.846  1.00 93.36  ? 1538 ARG D NH2 1 
ATOM   8013 N N   . ARG F 3 195 ? -41.153 -3.302  -75.921  1.00 75.99  ? 1539 ARG D N   1 
ATOM   8014 C CA  . ARG F 3 195 ? -40.651 -1.936  -75.920  1.00 62.18  ? 1539 ARG D CA  1 
ATOM   8015 C C   . ARG F 3 195 ? -41.667 -1.025  -76.594  1.00 62.50  ? 1539 ARG D C   1 
ATOM   8016 O O   . ARG F 3 195 ? -42.242 -1.379  -77.627  1.00 68.58  ? 1539 ARG D O   1 
ATOM   8017 C CB  . ARG F 3 195 ? -39.308 -1.852  -76.648  1.00 58.25  ? 1539 ARG D CB  1 
ATOM   8018 C CG  . ARG F 3 195 ? -38.259 -2.837  -76.164  1.00 54.51  ? 1539 ARG D CG  1 
ATOM   8019 C CD  . ARG F 3 195 ? -37.620 -3.562  -77.336  1.00 74.20  ? 1539 ARG D CD  1 
ATOM   8020 N NE  . ARG F 3 195 ? -36.338 -2.981  -77.716  1.00 92.39  ? 1539 ARG D NE  1 
ATOM   8021 C CZ  . ARG F 3 195 ? -35.641 -3.339  -78.787  1.00 107.48 ? 1539 ARG D CZ  1 
ATOM   8022 N NH1 . ARG F 3 195 ? -36.081 -4.268  -79.620  1.00 88.17  ? 1539 ARG D NH1 1 
ATOM   8023 N NH2 . ARG F 3 195 ? -34.473 -2.750  -79.028  1.00 100.42 ? 1539 ARG D NH2 1 
ATOM   8024 N N   . TYR F 3 196 ? -41.897 0.148   -76.005  1.00 64.78  ? 1540 TYR D N   1 
ATOM   8025 C CA  . TYR F 3 196 ? -42.807 1.099   -76.628  1.00 65.23  ? 1540 TYR D CA  1 
ATOM   8026 C C   . TYR F 3 196 ? -42.156 1.716   -77.858  1.00 68.19  ? 1540 TYR D C   1 
ATOM   8027 O O   . TYR F 3 196 ? -40.997 2.140   -77.816  1.00 63.08  ? 1540 TYR D O   1 
ATOM   8028 C CB  . TYR F 3 196 ? -43.223 2.208   -75.661  1.00 59.19  ? 1540 TYR D CB  1 
ATOM   8029 C CG  . TYR F 3 196 ? -44.014 3.288   -76.375  1.00 52.82  ? 1540 TYR D CG  1 
ATOM   8030 C CD1 . TYR F 3 196 ? -45.313 3.048   -76.809  1.00 64.24  ? 1540 TYR D CD1 1 
ATOM   8031 C CD2 . TYR F 3 196 ? -43.449 4.526   -76.658  1.00 51.11  ? 1540 TYR D CD2 1 
ATOM   8032 C CE1 . TYR F 3 196 ? -46.038 4.017   -77.482  1.00 58.72  ? 1540 TYR D CE1 1 
ATOM   8033 C CE2 . TYR F 3 196 ? -44.168 5.505   -77.333  1.00 54.90  ? 1540 TYR D CE2 1 
ATOM   8034 C CZ  . TYR F 3 196 ? -45.462 5.243   -77.742  1.00 56.21  ? 1540 TYR D CZ  1 
ATOM   8035 O OH  . TYR F 3 196 ? -46.185 6.204   -78.416  1.00 35.13  ? 1540 TYR D OH  1 
ATOM   8036 N N   . CYS F 3 197 ? -42.910 1.768   -78.952  1.00 58.77  ? 1541 CYS D N   1 
ATOM   8037 C CA  . CYS F 3 197 ? -42.471 2.421   -80.181  1.00 43.31  ? 1541 CYS D CA  1 
ATOM   8038 C C   . CYS F 3 197 ? -43.681 3.114   -80.788  1.00 51.14  ? 1541 CYS D C   1 
ATOM   8039 O O   . CYS F 3 197 ? -44.630 2.440   -81.201  1.00 63.99  ? 1541 CYS D O   1 
ATOM   8040 C CB  . CYS F 3 197 ? -41.867 1.416   -81.160  1.00 40.32  ? 1541 CYS D CB  1 
ATOM   8041 S SG  . CYS F 3 197 ? -40.074 1.259   -81.041  1.00 64.25  ? 1541 CYS D SG  1 
ATOM   8042 N N   . ASP F 3 198 ? -43.653 4.455   -80.823  1.00 45.30  ? 1542 ASP D N   1 
ATOM   8043 C CA  . ASP F 3 198 ? -44.729 5.251   -81.405  1.00 42.60  ? 1542 ASP D CA  1 
ATOM   8044 C C   . ASP F 3 198 ? -45.037 4.717   -82.797  1.00 52.23  ? 1542 ASP D C   1 
ATOM   8045 O O   . ASP F 3 198 ? -44.215 4.854   -83.712  1.00 64.70  ? 1542 ASP D O   1 
ATOM   8046 C CB  . ASP F 3 198 ? -44.350 6.734   -81.458  1.00 46.58  ? 1542 ASP D CB  1 
ATOM   8047 C CG  . ASP F 3 198 ? -45.548 7.641   -81.725  1.00 53.31  ? 1542 ASP D CG  1 
ATOM   8048 O OD1 . ASP F 3 198 ? -46.588 7.145   -82.208  1.00 53.86  ? 1542 ASP D OD1 1 
ATOM   8049 O OD2 . ASP F 3 198 ? -45.451 8.856   -81.447  1.00 53.29  ? 1542 ASP D OD2 1 
ATOM   8050 N N   . PRO F 3 199 ? -46.203 4.093   -82.989  1.00 50.77  ? 1543 PRO D N   1 
ATOM   8051 C CA  . PRO F 3 199 ? -46.451 3.381   -84.254  1.00 55.76  ? 1543 PRO D CA  1 
ATOM   8052 C C   . PRO F 3 199 ? -46.446 4.283   -85.474  1.00 53.62  ? 1543 PRO D C   1 
ATOM   8053 O O   . PRO F 3 199 ? -46.067 3.830   -86.562  1.00 54.96  ? 1543 PRO D O   1 
ATOM   8054 C CB  . PRO F 3 199 ? -47.829 2.739   -84.029  1.00 54.04  ? 1543 PRO D CB  1 
ATOM   8055 C CG  . PRO F 3 199 ? -48.014 2.724   -82.538  1.00 49.99  ? 1543 PRO D CG  1 
ATOM   8056 C CD  . PRO F 3 199 ? -47.324 3.955   -82.046  1.00 42.34  ? 1543 PRO D CD  1 
ATOM   8057 N N   . VAL F 3 200 ? -46.846 5.547   -85.333  1.00 44.35  ? 1544 VAL D N   1 
ATOM   8058 C CA  . VAL F 3 200 ? -46.848 6.437   -86.489  1.00 42.75  ? 1544 VAL D CA  1 
ATOM   8059 C C   . VAL F 3 200 ? -45.431 6.881   -86.832  1.00 43.78  ? 1544 VAL D C   1 
ATOM   8060 O O   . VAL F 3 200 ? -45.087 7.035   -88.009  1.00 61.67  ? 1544 VAL D O   1 
ATOM   8061 C CB  . VAL F 3 200 ? -47.794 7.631   -86.248  1.00 38.70  ? 1544 VAL D CB  1 
ATOM   8062 C CG1 . VAL F 3 200 ? -49.101 7.149   -85.639  1.00 59.14  ? 1544 VAL D CG1 1 
ATOM   8063 C CG2 . VAL F 3 200 ? -47.154 8.680   -85.349  1.00 58.47  ? 1544 VAL D CG2 1 
ATOM   8064 N N   . VAL F 3 201 ? -44.578 7.071   -85.822  1.00 38.10  ? 1545 VAL D N   1 
ATOM   8065 C CA  . VAL F 3 201 ? -43.188 7.419   -86.091  1.00 34.28  ? 1545 VAL D CA  1 
ATOM   8066 C C   . VAL F 3 201 ? -42.451 6.219   -86.666  1.00 52.51  ? 1545 VAL D C   1 
ATOM   8067 O O   . VAL F 3 201 ? -41.615 6.356   -87.567  1.00 59.78  ? 1545 VAL D O   1 
ATOM   8068 C CB  . VAL F 3 201 ? -42.515 7.953   -84.813  1.00 36.33  ? 1545 VAL D CB  1 
ATOM   8069 C CG1 . VAL F 3 201 ? -41.015 7.701   -84.841  1.00 43.90  ? 1545 VAL D CG1 1 
ATOM   8070 C CG2 . VAL F 3 201 ? -42.806 9.437   -84.645  1.00 40.41  ? 1545 VAL D CG2 1 
ATOM   8071 N N   . LEU F 3 202 ? -42.771 5.020   -86.177  1.00 63.47  ? 1546 LEU D N   1 
ATOM   8072 C CA  . LEU F 3 202 ? -42.149 3.813   -86.709  1.00 60.91  ? 1546 LEU D CA  1 
ATOM   8073 C C   . LEU F 3 202 ? -42.461 3.630   -88.188  1.00 53.39  ? 1546 LEU D C   1 
ATOM   8074 O O   . LEU F 3 202 ? -41.595 3.210   -88.965  1.00 52.54  ? 1546 LEU D O   1 
ATOM   8075 C CB  . LEU F 3 202 ? -42.616 2.596   -85.922  1.00 51.40  ? 1546 LEU D CB  1 
ATOM   8076 C CG  . LEU F 3 202 ? -41.647 1.419   -85.893  1.00 51.42  ? 1546 LEU D CG  1 
ATOM   8077 C CD1 . LEU F 3 202 ? -40.183 1.859   -85.988  1.00 49.39  ? 1546 LEU D CD1 1 
ATOM   8078 C CD2 . LEU F 3 202 ? -41.905 0.643   -84.633  1.00 49.14  ? 1546 LEU D CD2 1 
ATOM   8079 N N   . THR F 3 203 ? -43.698 3.921   -88.594  1.00 57.16  ? 1547 THR D N   1 
ATOM   8080 C CA  . THR F 3 203 ? -44.062 3.780   -90.000  1.00 60.65  ? 1547 THR D CA  1 
ATOM   8081 C C   . THR F 3 203 ? -43.422 4.878   -90.844  1.00 65.67  ? 1547 THR D C   1 
ATOM   8082 O O   . THR F 3 203 ? -42.945 4.614   -91.955  1.00 74.50  ? 1547 THR D O   1 
ATOM   8083 C CB  . THR F 3 203 ? -45.588 3.782   -90.148  1.00 69.07  ? 1547 THR D CB  1 
ATOM   8084 O OG1 . THR F 3 203 ? -46.076 2.435   -90.091  1.00 61.02  ? 1547 THR D OG1 1 
ATOM   8085 C CG2 . THR F 3 203 ? -46.022 4.411   -91.470  1.00 69.10  ? 1547 THR D CG2 1 
ATOM   8086 N N   . TYR F 3 204 ? -43.377 6.109   -90.326  1.00 58.31  ? 1548 TYR D N   1 
ATOM   8087 C CA  . TYR F 3 204 ? -42.839 7.220   -91.108  1.00 56.41  ? 1548 TYR D CA  1 
ATOM   8088 C C   . TYR F 3 204 ? -41.340 7.069   -91.333  1.00 63.19  ? 1548 TYR D C   1 
ATOM   8089 O O   . TYR F 3 204 ? -40.852 7.233   -92.458  1.00 67.78  ? 1548 TYR D O   1 
ATOM   8090 C CB  . TYR F 3 204 ? -43.140 8.552   -90.420  1.00 47.00  ? 1548 TYR D CB  1 
ATOM   8091 C CG  . TYR F 3 204 ? -42.720 9.753   -91.242  1.00 52.86  ? 1548 TYR D CG  1 
ATOM   8092 C CD1 . TYR F 3 204 ? -41.445 10.293  -91.121  1.00 41.46  ? 1548 TYR D CD1 1 
ATOM   8093 C CD2 . TYR F 3 204 ? -43.595 10.336  -92.149  1.00 57.33  ? 1548 TYR D CD2 1 
ATOM   8094 C CE1 . TYR F 3 204 ? -41.056 11.383  -91.876  1.00 48.22  ? 1548 TYR D CE1 1 
ATOM   8095 C CE2 . TYR F 3 204 ? -43.216 11.426  -92.908  1.00 54.80  ? 1548 TYR D CE2 1 
ATOM   8096 C CZ  . TYR F 3 204 ? -41.946 11.946  -92.767  1.00 56.91  ? 1548 TYR D CZ  1 
ATOM   8097 O OH  . TYR F 3 204 ? -41.563 13.033  -93.521  1.00 67.20  ? 1548 TYR D OH  1 
ATOM   8098 N N   . GLN F 3 205 ? -40.588 6.774   -90.268  1.00 62.92  ? 1549 GLN D N   1 
ATOM   8099 C CA  . GLN F 3 205 ? -39.141 6.644   -90.407  1.00 63.04  ? 1549 GLN D CA  1 
ATOM   8100 C C   . GLN F 3 205 ? -38.766 5.484   -91.321  1.00 72.23  ? 1549 GLN D C   1 
ATOM   8101 O O   . GLN F 3 205 ? -37.760 5.556   -92.036  1.00 81.24  ? 1549 GLN D O   1 
ATOM   8102 C CB  . GLN F 3 205 ? -38.493 6.473   -89.031  1.00 55.84  ? 1549 GLN D CB  1 
ATOM   8103 C CG  . GLN F 3 205 ? -38.789 7.603   -88.055  1.00 43.39  ? 1549 GLN D CG  1 
ATOM   8104 C CD  . GLN F 3 205 ? -37.812 8.756   -88.179  1.00 47.54  ? 1549 GLN D CD  1 
ATOM   8105 O OE1 . GLN F 3 205 ? -36.782 8.644   -88.844  1.00 56.81  ? 1549 GLN D OE1 1 
ATOM   8106 N NE2 . GLN F 3 205 ? -38.132 9.876   -87.538  1.00 46.52  ? 1549 GLN D NE2 1 
ATOM   8107 N N   . ALA F 3 206 ? -39.567 4.417   -91.328  1.00 61.59  ? 1550 ALA D N   1 
ATOM   8108 C CA  . ALA F 3 206 ? -39.243 3.252   -92.143  1.00 59.66  ? 1550 ALA D CA  1 
ATOM   8109 C C   . ALA F 3 206 ? -39.613 3.462   -93.605  1.00 55.90  ? 1550 ALA D C   1 
ATOM   8110 O O   . ALA F 3 206 ? -38.876 3.035   -94.501  1.00 50.48  ? 1550 ALA D O   1 
ATOM   8111 C CB  . ALA F 3 206 ? -39.956 2.019   -91.596  1.00 48.25  ? 1550 ALA D CB  1 
ATOM   8112 N N   . GLU F 3 207 ? -40.741 4.123   -93.865  1.00 60.08  ? 1551 GLU D N   1 
ATOM   8113 C CA  . GLU F 3 207 ? -41.272 4.211   -95.218  1.00 62.26  ? 1551 GLU D CA  1 
ATOM   8114 C C   . GLU F 3 207 ? -40.831 5.461   -95.969  1.00 56.98  ? 1551 GLU D C   1 
ATOM   8115 O O   . GLU F 3 207 ? -40.794 5.443   -97.204  1.00 63.95  ? 1551 GLU D O   1 
ATOM   8116 C CB  . GLU F 3 207 ? -42.803 4.158   -95.185  1.00 52.28  ? 1551 GLU D CB  1 
ATOM   8117 C CG  . GLU F 3 207 ? -43.369 2.859   -94.637  1.00 44.35  ? 1551 GLU D CG  1 
ATOM   8118 C CD  . GLU F 3 207 ? -44.834 2.676   -94.982  1.00 67.07  ? 1551 GLU D CD  1 
ATOM   8119 O OE1 . GLU F 3 207 ? -45.571 3.686   -94.998  1.00 67.18  ? 1551 GLU D OE1 1 
ATOM   8120 O OE2 . GLU F 3 207 ? -45.249 1.524   -95.240  1.00 66.18  ? 1551 GLU D OE2 1 
ATOM   8121 N N   . ARG F 3 208 ? -40.501 6.555   -95.270  1.00 53.25  ? 1552 ARG D N   1 
ATOM   8122 C CA  . ARG F 3 208 ? -40.257 7.826   -95.947  1.00 45.28  ? 1552 ARG D CA  1 
ATOM   8123 C C   . ARG F 3 208 ? -38.996 8.536   -95.464  1.00 53.04  ? 1552 ARG D C   1 
ATOM   8124 O O   . ARG F 3 208 ? -38.828 9.728   -95.739  1.00 64.03  ? 1552 ARG D O   1 
ATOM   8125 C CB  . ARG F 3 208 ? -41.460 8.761   -95.786  1.00 55.00  ? 1552 ARG D CB  1 
ATOM   8126 C CG  . ARG F 3 208 ? -42.817 8.092   -95.924  1.00 64.34  ? 1552 ARG D CG  1 
ATOM   8127 C CD  . ARG F 3 208 ? -43.897 9.105   -96.261  1.00 81.51  ? 1552 ARG D CD  1 
ATOM   8128 N NE  . ARG F 3 208 ? -44.922 8.541   -97.129  1.00 88.32  ? 1552 ARG D NE  1 
ATOM   8129 C CZ  . ARG F 3 208 ? -45.336 9.097   -98.259  1.00 80.20  ? 1552 ARG D CZ  1 
ATOM   8130 N NH1 . ARG F 3 208 ? -44.829 10.240  -98.693  1.00 89.21  ? 1552 ARG D NH1 1 
ATOM   8131 N NH2 . ARG F 3 208 ? -46.284 8.493   -98.971  1.00 77.45  ? 1552 ARG D NH2 1 
ATOM   8132 N N   . MET F 3 209 ? -38.098 7.846   -94.762  1.00 55.75  ? 1553 MET D N   1 
ATOM   8133 C CA  . MET F 3 209 ? -36.917 8.504   -94.218  1.00 47.48  ? 1553 MET D CA  1 
ATOM   8134 C C   . MET F 3 209 ? -35.651 7.792   -94.678  1.00 52.23  ? 1553 MET D C   1 
ATOM   8135 O O   . MET F 3 209 ? -35.562 6.555   -94.576  1.00 62.39  ? 1553 MET D O   1 
ATOM   8136 C CB  . MET F 3 209 ? -36.969 8.551   -92.687  1.00 50.15  ? 1553 MET D CB  1 
ATOM   8137 C CG  . MET F 3 209 ? -36.122 9.655   -92.074  1.00 53.10  ? 1553 MET D CG  1 
ATOM   8138 S SD  . MET F 3 209 ? -36.997 11.228  -91.960  1.00 42.82  ? 1553 MET D SD  1 
ATOM   8139 C CE  . MET F 3 209 ? -35.703 12.294  -91.329  1.00 48.25  ? 1553 MET D CE  1 
ATOM   8140 N N   . PRO F 3 210 ? -34.659 8.525   -95.185  1.00 48.88  ? 1554 PRO D N   1 
ATOM   8141 C CA  . PRO F 3 210 ? -33.384 7.896   -95.548  1.00 48.96  ? 1554 PRO D CA  1 
ATOM   8142 C C   . PRO F 3 210 ? -32.682 7.332   -94.324  1.00 45.91  ? 1554 PRO D C   1 
ATOM   8143 O O   . PRO F 3 210 ? -32.845 7.825   -93.206  1.00 60.23  ? 1554 PRO D O   1 
ATOM   8144 C CB  . PRO F 3 210 ? -32.582 9.046   -96.170  1.00 52.91  ? 1554 PRO D CB  1 
ATOM   8145 C CG  . PRO F 3 210 ? -33.605 10.069  -96.559  1.00 57.12  ? 1554 PRO D CG  1 
ATOM   8146 C CD  . PRO F 3 210 ? -34.699 9.952   -95.544  1.00 53.50  ? 1554 PRO D CD  1 
ATOM   8147 N N   . GLU F 3 211 ? -31.882 6.288   -94.553  1.00 50.36  ? 1555 GLU D N   1 
ATOM   8148 C CA  . GLU F 3 211 ? -31.200 5.612   -93.452  1.00 58.13  ? 1555 GLU D CA  1 
ATOM   8149 C C   . GLU F 3 211 ? -30.321 6.582   -92.670  1.00 68.43  ? 1555 GLU D C   1 
ATOM   8150 O O   . GLU F 3 211 ? -30.428 6.681   -91.442  1.00 75.68  ? 1555 GLU D O   1 
ATOM   8151 C CB  . GLU F 3 211 ? -30.376 4.441   -93.996  1.00 64.70  ? 1555 GLU D CB  1 
ATOM   8152 C CG  . GLU F 3 211 ? -29.825 3.451   -92.954  1.00 79.20  ? 1555 GLU D CG  1 
ATOM   8153 C CD  . GLU F 3 211 ? -28.671 3.996   -92.118  1.00 86.77  ? 1555 GLU D CD  1 
ATOM   8154 O OE1 . GLU F 3 211 ? -27.512 3.900   -92.578  1.00 87.04  ? 1555 GLU D OE1 1 
ATOM   8155 O OE2 . GLU F 3 211 ? -28.912 4.473   -90.987  1.00 82.09  ? 1555 GLU D OE2 1 
ATOM   8156 N N   . GLN F 3 212 ? -29.459 7.324   -93.375  1.00 74.13  ? 1556 GLN D N   1 
ATOM   8157 C CA  . GLN F 3 212 ? -28.428 8.130   -92.721  1.00 75.36  ? 1556 GLN D CA  1 
ATOM   8158 C C   . GLN F 3 212 ? -29.011 9.114   -91.712  1.00 74.05  ? 1556 GLN D C   1 
ATOM   8159 O O   . GLN F 3 212 ? -28.313 9.528   -90.779  1.00 67.75  ? 1556 GLN D O   1 
ATOM   8160 C CB  . GLN F 3 212 ? -27.609 8.873   -93.778  1.00 70.20  ? 1556 GLN D CB  1 
ATOM   8161 C CG  . GLN F 3 212 ? -26.861 7.960   -94.745  1.00 81.09  ? 1556 GLN D CG  1 
ATOM   8162 C CD  . GLN F 3 212 ? -27.722 7.499   -95.913  1.00 86.63  ? 1556 GLN D CD  1 
ATOM   8163 O OE1 . GLN F 3 212 ? -28.765 6.870   -95.722  1.00 69.46  ? 1556 GLN D OE1 1 
ATOM   8164 N NE2 . GLN F 3 212 ? -27.284 7.804   -97.130  1.00 83.81  ? 1556 GLN D NE2 1 
ATOM   8165 N N   . ILE F 3 213 ? -30.277 9.497   -91.878  1.00 77.87  ? 1557 ILE D N   1 
ATOM   8166 C CA  . ILE F 3 213 ? -30.983 10.347  -90.925  1.00 73.35  ? 1557 ILE D CA  1 
ATOM   8167 C C   . ILE F 3 213 ? -32.078 9.599   -90.186  1.00 66.11  ? 1557 ILE D C   1 
ATOM   8168 O O   . ILE F 3 213 ? -32.779 10.205  -89.362  1.00 60.49  ? 1557 ILE D O   1 
ATOM   8169 C CB  . ILE F 3 213 ? -31.568 11.593  -91.616  1.00 63.59  ? 1557 ILE D CB  1 
ATOM   8170 C CG1 . ILE F 3 213 ? -32.226 11.203  -92.939  1.00 62.26  ? 1557 ILE D CG1 1 
ATOM   8171 C CG2 . ILE F 3 213 ? -30.490 12.641  -91.849  1.00 64.47  ? 1557 ILE D CG2 1 
ATOM   8172 C CD1 . ILE F 3 213 ? -32.605 12.381  -93.794  1.00 53.47  ? 1557 ILE D CD1 1 
ATOM   8173 N N   . ARG F 3 214 ? -32.247 8.304   -90.448  1.00 69.47  ? 1558 ARG D N   1 
ATOM   8174 C CA  . ARG F 3 214 ? -33.349 7.548   -89.867  1.00 54.75  ? 1558 ARG D CA  1 
ATOM   8175 C C   . ARG F 3 214 ? -33.174 7.397   -88.361  1.00 53.20  ? 1558 ARG D C   1 
ATOM   8176 O O   . ARG F 3 214 ? -32.058 7.236   -87.858  1.00 61.78  ? 1558 ARG D O   1 
ATOM   8177 C CB  . ARG F 3 214 ? -33.449 6.170   -90.523  1.00 54.99  ? 1558 ARG D CB  1 
ATOM   8178 C CG  . ARG F 3 214 ? -34.750 5.431   -90.256  1.00 51.87  ? 1558 ARG D CG  1 
ATOM   8179 C CD  . ARG F 3 214 ? -34.983 4.321   -91.281  1.00 56.22  ? 1558 ARG D CD  1 
ATOM   8180 N NE  . ARG F 3 214 ? -33.799 3.500   -91.513  1.00 80.58  ? 1558 ARG D NE  1 
ATOM   8181 C CZ  . ARG F 3 214 ? -33.305 2.621   -90.649  1.00 85.23  ? 1558 ARG D CZ  1 
ATOM   8182 N NH1 . ARG F 3 214 ? -33.864 2.421   -89.465  1.00 66.02  ? 1558 ARG D NH1 1 
ATOM   8183 N NH2 . ARG F 3 214 ? -32.223 1.922   -90.982  1.00 62.91  ? 1558 ARG D NH2 1 
ATOM   8184 N N   . LEU F 3 215 ? -34.292 7.450   -87.641  1.00 50.61  ? 1559 LEU D N   1 
ATOM   8185 C CA  . LEU F 3 215 ? -34.274 7.289   -86.193  1.00 56.28  ? 1559 LEU D CA  1 
ATOM   8186 C C   . LEU F 3 215 ? -34.019 5.828   -85.841  1.00 64.81  ? 1559 LEU D C   1 
ATOM   8187 O O   . LEU F 3 215 ? -34.757 4.939   -86.281  1.00 69.37  ? 1559 LEU D O   1 
ATOM   8188 C CB  . LEU F 3 215 ? -35.594 7.769   -85.595  1.00 39.10  ? 1559 LEU D CB  1 
ATOM   8189 C CG  . LEU F 3 215 ? -35.564 8.426   -84.211  1.00 38.73  ? 1559 LEU D CG  1 
ATOM   8190 C CD1 . LEU F 3 215 ? -34.229 9.105   -83.944  1.00 48.54  ? 1559 LEU D CD1 1 
ATOM   8191 C CD2 . LEU F 3 215 ? -36.703 9.423   -84.074  1.00 29.72  ? 1559 LEU D CD2 1 
ATOM   8192 N N   . LYS F 3 216 ? -32.971 5.580   -85.059  1.00 74.80  ? 1560 LYS D N   1 
ATOM   8193 C CA  . LYS F 3 216 ? -32.668 4.222   -84.628  1.00 73.22  ? 1560 LYS D CA  1 
ATOM   8194 C C   . LYS F 3 216 ? -33.778 3.698   -83.727  1.00 63.87  ? 1560 LYS D C   1 
ATOM   8195 O O   . LYS F 3 216 ? -34.267 4.402   -82.839  1.00 56.24  ? 1560 LYS D O   1 
ATOM   8196 C CB  . LYS F 3 216 ? -31.322 4.176   -83.903  1.00 71.30  ? 1560 LYS D CB  1 
ATOM   8197 C CG  . LYS F 3 216 ? -30.113 4.178   -84.836  1.00 77.87  ? 1560 LYS D CG  1 
ATOM   8198 C CD  . LYS F 3 216 ? -30.328 3.255   -86.032  1.00 83.25  ? 1560 LYS D CD  1 
ATOM   8199 C CE  . LYS F 3 216 ? -29.227 3.412   -87.073  1.00 65.92  ? 1560 LYS D CE  1 
ATOM   8200 N NZ  . LYS F 3 216 ? -29.537 4.485   -88.061  1.00 51.48  ? 1560 LYS D NZ  1 
ATOM   8201 N N   . VAL F 3 217 ? -34.177 2.449   -83.967  1.00 69.47  ? 1561 VAL D N   1 
ATOM   8202 C CA  . VAL F 3 217 ? -35.346 1.899   -83.291  1.00 52.44  ? 1561 VAL D CA  1 
ATOM   8203 C C   . VAL F 3 217 ? -35.041 1.626   -81.824  1.00 55.94  ? 1561 VAL D C   1 
ATOM   8204 O O   . VAL F 3 217 ? -35.773 2.065   -80.930  1.00 80.45  ? 1561 VAL D O   1 
ATOM   8205 C CB  . VAL F 3 217 ? -35.829 0.629   -84.012  1.00 63.47  ? 1561 VAL D CB  1 
ATOM   8206 C CG1 . VAL F 3 217 ? -37.103 0.118   -83.369  1.00 61.79  ? 1561 VAL D CG1 1 
ATOM   8207 C CG2 . VAL F 3 217 ? -36.035 0.906   -85.498  1.00 58.90  ? 1561 VAL D CG2 1 
ATOM   8208 N N   . GLY F 3 218 ? -33.958 0.899   -81.556  1.00 58.73  ? 1562 GLY D N   1 
ATOM   8209 C CA  . GLY F 3 218 ? -33.634 0.462   -80.212  1.00 89.62  ? 1562 GLY D CA  1 
ATOM   8210 C C   . GLY F 3 218 ? -33.544 1.569   -79.183  1.00 87.20  ? 1562 GLY D C   1 
ATOM   8211 O O   . GLY F 3 218 ? -34.283 1.575   -78.193  1.00 106.38 ? 1562 GLY D O   1 
ATOM   8212 N N   . GLY F 3 219 ? -32.653 2.508   -79.396  1.00 87.17  ? 1563 GLY D N   1 
ATOM   8213 C CA  . GLY F 3 219 ? -32.448 3.577   -78.439  1.00 73.84  ? 1563 GLY D CA  1 
ATOM   8214 C C   . GLY F 3 219 ? -31.839 4.765   -79.110  1.00 87.96  ? 1563 GLY D C   1 
ATOM   8215 O O   . GLY F 3 219 ? -32.045 4.994   -80.303  1.00 99.09  ? 1563 GLY D O   1 
ATOM   8216 N N   . VAL F 3 220 ? -31.082 5.542   -78.344  1.00 81.66  ? 1564 VAL D N   1 
ATOM   8217 C CA  . VAL F 3 220 ? -30.492 6.770   -78.854  1.00 86.17  ? 1564 VAL D CA  1 
ATOM   8218 C C   . VAL F 3 220 ? -28.985 6.727   -78.670  1.00 79.15  ? 1564 VAL D C   1 
ATOM   8219 O O   . VAL F 3 220 ? -28.484 6.315   -77.618  1.00 64.40  ? 1564 VAL D O   1 
ATOM   8220 C CB  . VAL F 3 220 ? -31.072 8.027   -78.184  1.00 81.20  ? 1564 VAL D CB  1 
ATOM   8221 C CG1 . VAL F 3 220 ? -30.842 9.216   -79.088  1.00 70.20  ? 1564 VAL D CG1 1 
ATOM   8222 C CG2 . VAL F 3 220 ? -32.546 7.847   -77.860  1.00 81.24  ? 1564 VAL D CG2 1 
ATOM   8223 N N   . ASP F 3 221 ? -28.269 7.187   -79.692  1.00 89.89  ? 1565 ASP D N   1 
ATOM   8224 C CA  . ASP F 3 221 ? -26.818 7.144   -79.731  1.00 89.49  ? 1565 ASP D CA  1 
ATOM   8225 C C   . ASP F 3 221 ? -26.216 8.309   -78.945  1.00 89.60  ? 1565 ASP D C   1 
ATOM   8226 O O   . ASP F 3 221 ? -26.783 9.405   -78.910  1.00 81.99  ? 1565 ASP D O   1 
ATOM   8227 C CB  . ASP F 3 221 ? -26.331 7.179   -81.176  1.00 85.76  ? 1565 ASP D CB  1 
ATOM   8228 C CG  . ASP F 3 221 ? -26.072 5.792   -81.732  1.00 93.52  ? 1565 ASP D CG  1 
ATOM   8229 O OD1 . ASP F 3 221 ? -25.233 5.068   -81.154  1.00 96.01  ? 1565 ASP D OD1 1 
ATOM   8230 O OD2 . ASP F 3 221 ? -26.708 5.424   -82.744  1.00 84.74  ? 1565 ASP D OD2 1 
ATOM   8231 N N   . PRO F 3 222 ? -25.052 8.099   -78.320  1.00 98.72  ? 1566 PRO D N   1 
ATOM   8232 C CA  . PRO F 3 222 ? -24.511 9.144   -77.439  1.00 97.11  ? 1566 PRO D CA  1 
ATOM   8233 C C   . PRO F 3 222 ? -23.971 10.345  -78.193  1.00 98.27  ? 1566 PRO D C   1 
ATOM   8234 O O   . PRO F 3 222 ? -23.928 11.447  -77.632  1.00 92.76  ? 1566 PRO D O   1 
ATOM   8235 C CB  . PRO F 3 222 ? -23.406 8.415   -76.656  1.00 96.64  ? 1566 PRO D CB  1 
ATOM   8236 C CG  . PRO F 3 222 ? -23.194 7.085   -77.360  1.00 94.59  ? 1566 PRO D CG  1 
ATOM   8237 C CD  . PRO F 3 222 ? -24.065 7.037   -78.576  1.00 97.43  ? 1566 PRO D CD  1 
ATOM   8238 N N   . LYS F 3 223 ? -23.558 10.169  -79.451  1.00 88.86  ? 1567 LYS D N   1 
ATOM   8239 C CA  . LYS F 3 223 ? -23.142 11.312  -80.255  1.00 96.35  ? 1567 LYS D CA  1 
ATOM   8240 C C   . LYS F 3 223 ? -24.335 12.170  -80.656  1.00 95.64  ? 1567 LYS D C   1 
ATOM   8241 O O   . LYS F 3 223 ? -24.180 13.371  -80.908  1.00 91.51  ? 1567 LYS D O   1 
ATOM   8242 C CB  . LYS F 3 223 ? -22.386 10.828  -81.492  1.00 83.88  ? 1567 LYS D CB  1 
ATOM   8243 C CG  . LYS F 3 223 ? -21.684 9.489   -81.299  1.00 88.58  ? 1567 LYS D CG  1 
ATOM   8244 C CD  . LYS F 3 223 ? -20.172 9.655   -81.220  1.00 105.56 ? 1567 LYS D CD  1 
ATOM   8245 C CE  . LYS F 3 223 ? -19.468 8.308   -81.125  1.00 87.63  ? 1567 LYS D CE  1 
ATOM   8246 N NZ  . LYS F 3 223 ? -18.314 8.204   -82.067  1.00 54.16  ? 1567 LYS D NZ  1 
ATOM   8247 N N   . GLN F 3 224 ? -25.526 11.574  -80.713  1.00 87.22  ? 1568 GLN D N   1 
ATOM   8248 C CA  . GLN F 3 224 ? -26.733 12.316  -81.046  1.00 78.26  ? 1568 GLN D CA  1 
ATOM   8249 C C   . GLN F 3 224 ? -27.310 13.073  -79.854  1.00 72.76  ? 1568 GLN D C   1 
ATOM   8250 O O   . GLN F 3 224 ? -28.106 13.995  -80.061  1.00 73.38  ? 1568 GLN D O   1 
ATOM   8251 C CB  . GLN F 3 224 ? -27.792 11.366  -81.620  1.00 69.03  ? 1568 GLN D CB  1 
ATOM   8252 C CG  . GLN F 3 224 ? -27.389 10.687  -82.924  1.00 63.02  ? 1568 GLN D CG  1 
ATOM   8253 C CD  . GLN F 3 224 ? -27.777 11.492  -84.150  1.00 71.41  ? 1568 GLN D CD  1 
ATOM   8254 O OE1 . GLN F 3 224 ? -27.090 12.441  -84.528  1.00 73.04  ? 1568 GLN D OE1 1 
ATOM   8255 N NE2 . GLN F 3 224 ? -28.881 11.111  -84.783  1.00 73.80  ? 1568 GLN D NE2 1 
ATOM   8256 N N   . LEU F 3 225 ? -26.929 12.718  -78.620  1.00 60.42  ? 1569 LEU D N   1 
ATOM   8257 C CA  . LEU F 3 225 ? -27.439 13.393  -77.428  1.00 58.51  ? 1569 LEU D CA  1 
ATOM   8258 C C   . LEU F 3 225 ? -26.768 14.725  -77.156  1.00 62.91  ? 1569 LEU D C   1 
ATOM   8259 O O   . LEU F 3 225 ? -27.067 15.340  -76.127  1.00 65.00  ? 1569 LEU D O   1 
ATOM   8260 C CB  . LEU F 3 225 ? -27.256 12.532  -76.179  1.00 55.98  ? 1569 LEU D CB  1 
ATOM   8261 C CG  . LEU F 3 225 ? -28.498 11.775  -75.743  1.00 41.62  ? 1569 LEU D CG  1 
ATOM   8262 C CD1 . LEU F 3 225 ? -29.687 12.715  -75.579  1.00 41.88  ? 1569 LEU D CD1 1 
ATOM   8263 C CD2 . LEU F 3 225 ? -28.770 10.689  -76.748  1.00 63.01  ? 1569 LEU D CD2 1 
ATOM   8264 N N   . ALA F 3 226 ? -25.857 15.167  -78.022  1.00 55.69  ? 1570 ALA D N   1 
ATOM   8265 C CA  . ALA F 3 226 ? -25.084 16.366  -77.722  1.00 51.12  ? 1570 ALA D CA  1 
ATOM   8266 C C   . ALA F 3 226 ? -25.985 17.582  -77.537  1.00 62.52  ? 1570 ALA D C   1 
ATOM   8267 O O   . ALA F 3 226 ? -25.720 18.429  -76.675  1.00 64.55  ? 1570 ALA D O   1 
ATOM   8268 C CB  . ALA F 3 226 ? -24.058 16.616  -78.824  1.00 61.78  ? 1570 ALA D CB  1 
ATOM   8269 N N   . VAL F 3 227 ? -27.059 17.685  -78.329  1.00 61.52  ? 1571 VAL D N   1 
ATOM   8270 C CA  . VAL F 3 227 ? -27.967 18.826  -78.196  1.00 51.58  ? 1571 VAL D CA  1 
ATOM   8271 C C   . VAL F 3 227 ? -28.609 18.842  -76.814  1.00 57.72  ? 1571 VAL D C   1 
ATOM   8272 O O   . VAL F 3 227 ? -28.614 19.870  -76.127  1.00 68.33  ? 1571 VAL D O   1 
ATOM   8273 C CB  . VAL F 3 227 ? -29.026 18.828  -79.317  1.00 48.13  ? 1571 VAL D CB  1 
ATOM   8274 C CG1 . VAL F 3 227 ? -28.366 18.923  -80.662  1.00 64.08  ? 1571 VAL D CG1 1 
ATOM   8275 C CG2 . VAL F 3 227 ? -29.897 17.576  -79.275  1.00 60.88  ? 1571 VAL D CG2 1 
ATOM   8276 N N   . TYR F 3 228 ? -29.148 17.702  -76.379  1.00 55.94  ? 1572 TYR D N   1 
ATOM   8277 C CA  . TYR F 3 228 ? -29.797 17.648  -75.078  1.00 58.27  ? 1572 TYR D CA  1 
ATOM   8278 C C   . TYR F 3 228 ? -28.785 17.629  -73.946  1.00 64.22  ? 1572 TYR D C   1 
ATOM   8279 O O   . TYR F 3 228 ? -29.132 17.979  -72.815  1.00 72.40  ? 1572 TYR D O   1 
ATOM   8280 C CB  . TYR F 3 228 ? -30.716 16.429  -75.000  1.00 46.47  ? 1572 TYR D CB  1 
ATOM   8281 C CG  . TYR F 3 228 ? -31.925 16.532  -75.902  1.00 40.34  ? 1572 TYR D CG  1 
ATOM   8282 C CD1 . TYR F 3 228 ? -32.965 17.409  -75.608  1.00 31.29  ? 1572 TYR D CD1 1 
ATOM   8283 C CD2 . TYR F 3 228 ? -32.020 15.765  -77.056  1.00 35.35  ? 1572 TYR D CD2 1 
ATOM   8284 C CE1 . TYR F 3 228 ? -34.069 17.512  -76.435  1.00 28.92  ? 1572 TYR D CE1 1 
ATOM   8285 C CE2 . TYR F 3 228 ? -33.119 15.860  -77.889  1.00 34.18  ? 1572 TYR D CE2 1 
ATOM   8286 C CZ  . TYR F 3 228 ? -34.140 16.734  -77.575  1.00 39.71  ? 1572 TYR D CZ  1 
ATOM   8287 O OH  . TYR F 3 228 ? -35.235 16.827  -78.405  1.00 48.22  ? 1572 TYR D OH  1 
ATOM   8288 N N   . GLU F 3 229 ? -27.540 17.242  -74.227  1.00 59.27  ? 1573 GLU D N   1 
ATOM   8289 C CA  . GLU F 3 229 ? -26.501 17.300  -73.208  1.00 68.75  ? 1573 GLU D CA  1 
ATOM   8290 C C   . GLU F 3 229 ? -25.950 18.713  -73.055  1.00 65.58  ? 1573 GLU D C   1 
ATOM   8291 O O   . GLU F 3 229 ? -25.683 19.159  -71.933  1.00 45.48  ? 1573 GLU D O   1 
ATOM   8292 C CB  . GLU F 3 229 ? -25.382 16.316  -73.546  1.00 61.70  ? 1573 GLU D CB  1 
ATOM   8293 C CG  . GLU F 3 229 ? -25.624 14.913  -73.022  1.00 64.11  ? 1573 GLU D CG  1 
ATOM   8294 C CD  . GLU F 3 229 ? -24.342 14.212  -72.627  1.00 78.24  ? 1573 GLU D CD  1 
ATOM   8295 O OE1 . GLU F 3 229 ? -23.409 14.167  -73.456  1.00 89.90  ? 1573 GLU D OE1 1 
ATOM   8296 O OE2 . GLU F 3 229 ? -24.265 13.711  -71.485  1.00 95.08  ? 1573 GLU D OE2 1 
ATOM   8297 N N   . GLU F 3 230 ? -25.776 19.431  -74.169  1.00 71.70  ? 1574 GLU D N   1 
ATOM   8298 C CA  . GLU F 3 230 ? -25.361 20.829  -74.100  1.00 70.18  ? 1574 GLU D CA  1 
ATOM   8299 C C   . GLU F 3 230 ? -26.459 21.715  -73.525  1.00 66.93  ? 1574 GLU D C   1 
ATOM   8300 O O   . GLU F 3 230 ? -26.155 22.774  -72.961  1.00 72.44  ? 1574 GLU D O   1 
ATOM   8301 C CB  . GLU F 3 230 ? -24.939 21.323  -75.490  1.00 54.83  ? 1574 GLU D CB  1 
ATOM   8302 C CG  . GLU F 3 230 ? -24.679 22.823  -75.591  1.00 62.93  ? 1574 GLU D CG  1 
ATOM   8303 C CD  . GLU F 3 230 ? -23.218 23.189  -75.446  1.00 75.23  ? 1574 GLU D CD  1 
ATOM   8304 O OE1 . GLU F 3 230 ? -22.463 22.399  -74.845  1.00 84.36  ? 1574 GLU D OE1 1 
ATOM   8305 O OE2 . GLU F 3 230 ? -22.827 24.274  -75.927  1.00 68.45  ? 1574 GLU D OE2 1 
ATOM   8306 N N   . PHE F 3 231 ? -27.724 21.297  -73.639  1.00 65.21  ? 1575 PHE D N   1 
ATOM   8307 C CA  . PHE F 3 231 ? -28.813 22.027  -72.996  1.00 65.12  ? 1575 PHE D CA  1 
ATOM   8308 C C   . PHE F 3 231 ? -28.608 22.127  -71.488  1.00 70.09  ? 1575 PHE D C   1 
ATOM   8309 O O   . PHE F 3 231 ? -29.115 23.060  -70.854  1.00 70.09  ? 1575 PHE D O   1 
ATOM   8310 C CB  . PHE F 3 231 ? -30.153 21.354  -73.305  1.00 53.58  ? 1575 PHE D CB  1 
ATOM   8311 C CG  . PHE F 3 231 ? -30.824 21.864  -74.554  1.00 48.26  ? 1575 PHE D CG  1 
ATOM   8312 C CD1 . PHE F 3 231 ? -30.911 23.222  -74.806  1.00 45.30  ? 1575 PHE D CD1 1 
ATOM   8313 C CD2 . PHE F 3 231 ? -31.383 20.983  -75.466  1.00 51.15  ? 1575 PHE D CD2 1 
ATOM   8314 C CE1 . PHE F 3 231 ? -31.536 23.693  -75.946  1.00 50.23  ? 1575 PHE D CE1 1 
ATOM   8315 C CE2 . PHE F 3 231 ? -32.006 21.447  -76.613  1.00 51.92  ? 1575 PHE D CE2 1 
ATOM   8316 C CZ  . PHE F 3 231 ? -32.083 22.804  -76.852  1.00 50.05  ? 1575 PHE D CZ  1 
ATOM   8317 N N   . ALA F 3 232 ? -27.874 21.182  -70.899  1.00 66.96  ? 1576 ALA D N   1 
ATOM   8318 C CA  . ALA F 3 232 ? -27.538 21.232  -69.482  1.00 60.53  ? 1576 ALA D CA  1 
ATOM   8319 C C   . ALA F 3 232 ? -26.195 21.908  -69.233  1.00 73.62  ? 1576 ALA D C   1 
ATOM   8320 O O   . ALA F 3 232 ? -26.023 22.586  -68.215  1.00 90.91  ? 1576 ALA D O   1 
ATOM   8321 C CB  . ALA F 3 232 ? -27.522 19.820  -68.892  1.00 60.39  ? 1576 ALA D CB  1 
ATOM   8322 N N   . ARG F 3 233 ? -25.239 21.730  -70.148  1.00 69.94  ? 1577 ARG D N   1 
ATOM   8323 C CA  . ARG F 3 233 ? -23.924 22.342  -69.992  1.00 63.36  ? 1577 ARG D CA  1 
ATOM   8324 C C   . ARG F 3 233 ? -24.024 23.861  -69.985  1.00 59.73  ? 1577 ARG D C   1 
ATOM   8325 O O   . ARG F 3 233 ? -23.704 24.518  -68.987  1.00 61.92  ? 1577 ARG D O   1 
ATOM   8326 C CB  . ARG F 3 233 ? -22.997 21.870  -71.113  1.00 64.83  ? 1577 ARG D CB  1 
ATOM   8327 C CG  . ARG F 3 233 ? -21.522 22.076  -70.829  1.00 71.04  ? 1577 ARG D CG  1 
ATOM   8328 C CD  . ARG F 3 233 ? -20.735 22.272  -72.117  1.00 82.18  ? 1577 ARG D CD  1 
ATOM   8329 N NE  . ARG F 3 233 ? -21.182 23.434  -72.876  1.00 89.46  ? 1577 ARG D NE  1 
ATOM   8330 C CZ  . ARG F 3 233 ? -20.563 24.607  -72.884  1.00 88.82  ? 1577 ARG D CZ  1 
ATOM   8331 N NH1 . ARG F 3 233 ? -19.471 24.818  -72.168  1.00 85.95  ? 1577 ARG D NH1 1 
ATOM   8332 N NH2 . ARG F 3 233 ? -21.053 25.594  -73.629  1.00 79.66  ? 1577 ARG D NH2 1 
ATOM   8333 N N   . ASN F 3 234 ? -24.472 24.436  -71.096  1.00 71.68  ? 1578 ASN D N   1 
ATOM   8334 C CA  . ASN F 3 234 ? -24.572 25.883  -71.257  1.00 78.04  ? 1578 ASN D CA  1 
ATOM   8335 C C   . ASN F 3 234 ? -26.018 26.291  -70.999  1.00 73.24  ? 1578 ASN D C   1 
ATOM   8336 O O   . ASN F 3 234 ? -26.890 26.100  -71.851  1.00 75.60  ? 1578 ASN D O   1 
ATOM   8337 C CB  . ASN F 3 234 ? -24.103 26.300  -72.648  1.00 65.34  ? 1578 ASN D CB  1 
ATOM   8338 C CG  . ASN F 3 234 ? -24.534 27.706  -73.013  1.00 73.46  ? 1578 ASN D CG  1 
ATOM   8339 O OD1 . ASN F 3 234 ? -23.778 28.660  -72.835  1.00 81.81  ? 1578 ASN D OD1 1 
ATOM   8340 N ND2 . ASN F 3 234 ? -25.743 27.839  -73.555  1.00 80.44  ? 1578 ASN D ND2 1 
ATOM   8341 N N   . VAL F 3 235 ? -26.269 26.852  -69.827  1.00 73.33  ? 1579 VAL D N   1 
ATOM   8342 C CA  . VAL F 3 235 ? -27.575 27.402  -69.475  1.00 68.94  ? 1579 VAL D CA  1 
ATOM   8343 C C   . VAL F 3 235 ? -27.513 28.914  -69.657  1.00 64.32  ? 1579 VAL D C   1 
ATOM   8344 O O   . VAL F 3 235 ? -26.609 29.552  -69.100  1.00 69.70  ? 1579 VAL D O   1 
ATOM   8345 C CB  . VAL F 3 235 ? -27.977 27.045  -68.034  1.00 66.77  ? 1579 VAL D CB  1 
ATOM   8346 C CG1 . VAL F 3 235 ? -29.380 27.557  -67.738  1.00 57.02  ? 1579 VAL D CG1 1 
ATOM   8347 C CG2 . VAL F 3 235 ? -27.887 25.544  -67.814  1.00 68.79  ? 1579 VAL D CG2 1 
ATOM   8348 N N   . PRO F 3 236 ? -28.428 29.515  -70.418  1.00 56.97  ? 1580 PRO D N   1 
ATOM   8349 C CA  . PRO F 3 236 ? -28.370 30.969  -70.644  1.00 70.19  ? 1580 PRO D CA  1 
ATOM   8350 C C   . PRO F 3 236 ? -28.494 31.741  -69.339  1.00 73.14  ? 1580 PRO D C   1 
ATOM   8351 O O   . PRO F 3 236 ? -29.474 31.604  -68.602  1.00 70.34  ? 1580 PRO D O   1 
ATOM   8352 C CB  . PRO F 3 236 ? -29.557 31.238  -71.578  1.00 55.12  ? 1580 PRO D CB  1 
ATOM   8353 C CG  . PRO F 3 236 ? -30.381 30.000  -71.583  1.00 57.24  ? 1580 PRO D CG  1 
ATOM   8354 C CD  . PRO F 3 236 ? -29.519 28.862  -71.157  1.00 61.40  ? 1580 PRO D CD  1 
ATOM   8355 N N   . GLY F 3 237 ? -27.482 32.560  -69.056  1.00 68.19  ? 1581 GLY D N   1 
ATOM   8356 C CA  . GLY F 3 237 ? -27.461 33.395  -67.876  1.00 54.50  ? 1581 GLY D CA  1 
ATOM   8357 C C   . GLY F 3 237 ? -26.581 32.897  -66.749  1.00 71.01  ? 1581 GLY D C   1 
ATOM   8358 O O   . GLY F 3 237 ? -26.385 33.631  -65.773  1.00 83.40  ? 1581 GLY D O   1 
ATOM   8359 N N   . PHE F 3 238 ? -26.036 31.686  -66.853  1.00 65.13  ? 1582 PHE D N   1 
ATOM   8360 C CA  . PHE F 3 238 ? -25.269 31.082  -65.773  1.00 76.10  ? 1582 PHE D CA  1 
ATOM   8361 C C   . PHE F 3 238 ? -23.921 30.596  -66.289  1.00 64.71  ? 1582 PHE D C   1 
ATOM   8362 O O   . PHE F 3 238 ? -23.655 30.581  -67.494  1.00 62.05  ? 1582 PHE D O   1 
ATOM   8363 C CB  . PHE F 3 238 ? -26.031 29.912  -65.135  1.00 84.18  ? 1582 PHE D CB  1 
ATOM   8364 C CG  . PHE F 3 238 ? -27.383 30.284  -64.594  1.00 78.30  ? 1582 PHE D CG  1 
ATOM   8365 C CD1 . PHE F 3 238 ? -27.525 31.318  -63.685  1.00 77.36  ? 1582 PHE D CD1 1 
ATOM   8366 C CD2 . PHE F 3 238 ? -28.513 29.594  -64.996  1.00 74.16  ? 1582 PHE D CD2 1 
ATOM   8367 C CE1 . PHE F 3 238 ? -28.772 31.651  -63.186  1.00 72.78  ? 1582 PHE D CE1 1 
ATOM   8368 C CE2 . PHE F 3 238 ? -29.760 29.927  -64.504  1.00 81.52  ? 1582 PHE D CE2 1 
ATOM   8369 C CZ  . PHE F 3 238 ? -29.890 30.957  -63.597  1.00 80.42  ? 1582 PHE D CZ  1 
ATOM   8370 N N   . LEU F 3 239 ? -23.066 30.198  -65.347  1.00 80.79  ? 1583 LEU D N   1 
ATOM   8371 C CA  . LEU F 3 239 ? -21.812 29.548  -65.690  1.00 81.30  ? 1583 LEU D CA  1 
ATOM   8372 C C   . LEU F 3 239 ? -22.088 28.206  -66.366  1.00 84.17  ? 1583 LEU D C   1 
ATOM   8373 O O   . LEU F 3 239 ? -23.062 27.525  -66.035  1.00 97.70  ? 1583 LEU D O   1 
ATOM   8374 C CB  . LEU F 3 239 ? -20.963 29.292  -64.443  1.00 94.45  ? 1583 LEU D CB  1 
ATOM   8375 C CG  . LEU F 3 239 ? -19.812 30.179  -63.950  1.00 94.89  ? 1583 LEU D CG  1 
ATOM   8376 C CD1 . LEU F 3 239 ? -18.541 29.907  -64.754  1.00 91.75  ? 1583 LEU D CD1 1 
ATOM   8377 C CD2 . LEU F 3 239 ? -20.143 31.663  -63.900  1.00 79.89  ? 1583 LEU D CD2 1 
ATOM   8378 N N   . PRO F 3 240 ? -21.249 27.798  -67.316  1.00 79.27  ? 1584 PRO D N   1 
ATOM   8379 C CA  . PRO F 3 240 ? -21.228 26.383  -67.700  1.00 86.81  ? 1584 PRO D CA  1 
ATOM   8380 C C   . PRO F 3 240 ? -20.740 25.540  -66.531  1.00 95.54  ? 1584 PRO D C   1 
ATOM   8381 O O   . PRO F 3 240 ? -20.024 26.019  -65.649  1.00 96.16  ? 1584 PRO D O   1 
ATOM   8382 C CB  . PRO F 3 240 ? -20.251 26.329  -68.881  1.00 89.17  ? 1584 PRO D CB  1 
ATOM   8383 C CG  . PRO F 3 240 ? -19.948 27.731  -69.256  1.00 94.94  ? 1584 PRO D CG  1 
ATOM   8384 C CD  . PRO F 3 240 ? -20.475 28.664  -68.222  1.00 86.98  ? 1584 PRO D CD  1 
ATOM   8385 N N   . THR F 3 241 ? -21.141 24.270  -66.524  1.00 101.65 ? 1585 THR D N   1 
ATOM   8386 C CA  . THR F 3 241 ? -20.787 23.383  -65.421  1.00 114.89 ? 1585 THR D CA  1 
ATOM   8387 C C   . THR F 3 241 ? -19.772 22.333  -65.861  1.00 127.00 ? 1585 THR D C   1 
ATOM   8388 O O   . THR F 3 241 ? -18.568 22.494  -65.636  1.00 117.77 ? 1585 THR D O   1 
ATOM   8389 C CB  . THR F 3 241 ? -22.038 22.711  -64.846  1.00 108.50 ? 1585 THR D CB  1 
ATOM   8390 O OG1 . THR F 3 241 ? -22.313 21.501  -65.563  1.00 99.18  ? 1585 THR D OG1 1 
ATOM   8391 C CG2 . THR F 3 241 ? -23.239 23.642  -64.951  1.00 94.05  ? 1585 THR D CG2 1 
ATOM   8392 N N   . ASN F 3 242 ? -20.249 21.251  -66.477  1.00 130.51 ? 1586 ASN D N   1 
ATOM   8393 C CA  . ASN F 3 242 ? -19.372 20.210  -67.016  1.00 126.76 ? 1586 ASN D CA  1 
ATOM   8394 C C   . ASN F 3 242 ? -19.029 20.553  -68.467  1.00 136.67 ? 1586 ASN D C   1 
ATOM   8395 O O   . ASN F 3 242 ? -19.452 19.899  -69.422  1.00 137.65 ? 1586 ASN D O   1 
ATOM   8396 C CB  . ASN F 3 242 ? -20.034 18.843  -66.899  1.00 106.21 ? 1586 ASN D CB  1 
ATOM   8397 C CG  . ASN F 3 242 ? -20.121 18.361  -65.465  1.00 106.98 ? 1586 ASN D CG  1 
ATOM   8398 O OD1 . ASN F 3 242 ? -21.139 18.544  -64.797  1.00 92.05  ? 1586 ASN D OD1 1 
ATOM   8399 N ND2 . ASN F 3 242 ? -19.051 17.738  -64.983  1.00 104.51 ? 1586 ASN D ND2 1 
ATOM   8400 N N   . ASP F 3 243 ? -18.232 21.611  -68.612  1.00 149.78 ? 1587 ASP D N   1 
ATOM   8401 C CA  . ASP F 3 243 ? -17.989 22.198  -69.924  1.00 149.53 ? 1587 ASP D CA  1 
ATOM   8402 C C   . ASP F 3 243 ? -17.070 21.318  -70.764  1.00 150.39 ? 1587 ASP D C   1 
ATOM   8403 O O   . ASP F 3 243 ? -16.039 20.836  -70.285  1.00 149.51 ? 1587 ASP D O   1 
ATOM   8404 C CB  . ASP F 3 243 ? -17.394 23.599  -69.775  1.00 145.43 ? 1587 ASP D CB  1 
ATOM   8405 C CG  . ASP F 3 243 ? -16.349 23.679  -68.679  1.00 159.48 ? 1587 ASP D CG  1 
ATOM   8406 O OD1 . ASP F 3 243 ? -16.619 23.196  -67.559  1.00 148.31 ? 1587 ASP D OD1 1 
ATOM   8407 O OD2 . ASP F 3 243 ? -15.258 24.231  -68.937  1.00 163.10 ? 1587 ASP D OD2 1 
ATOM   8408 N N   . LEU F 3 244 ? -17.451 21.116  -72.024  1.00 153.48 ? 1588 LEU D N   1 
ATOM   8409 C CA  . LEU F 3 244 ? -16.642 20.373  -72.987  1.00 151.17 ? 1588 LEU D CA  1 
ATOM   8410 C C   . LEU F 3 244 ? -16.918 20.900  -74.398  1.00 136.61 ? 1588 LEU D C   1 
ATOM   8411 O O   . LEU F 3 244 ? -17.828 20.448  -75.095  1.00 125.10 ? 1588 LEU D O   1 
ATOM   8412 C CB  . LEU F 3 244 ? -16.929 18.868  -72.896  1.00 135.19 ? 1588 LEU D CB  1 
ATOM   8413 C CG  . LEU F 3 244 ? -16.320 17.932  -73.947  1.00 109.71 ? 1588 LEU D CG  1 
ATOM   8414 C CD1 . LEU F 3 244 ? -14.872 17.604  -73.615  1.00 95.74  ? 1588 LEU D CD1 1 
ATOM   8415 C CD2 . LEU F 3 244 ? -17.145 16.657  -74.079  1.00 74.86  ? 1588 LEU D CD2 1 
ATOM   8416 O OXT . LEU F 3 244 ? -16.238 21.810  -74.874  1.00 125.70 ? 1588 LEU D OXT 1 
HETATM 8417 C C1  . BU1 G 4 .   ? -72.832 8.351   -53.904  1.00 50.84  ? 101  BU1 F C1  1 
HETATM 8418 C C2  . BU1 G 4 .   ? -72.999 8.377   -52.386  1.00 53.12  ? 101  BU1 F C2  1 
HETATM 8419 C C3  . BU1 G 4 .   ? -72.026 7.374   -51.771  1.00 55.51  ? 101  BU1 F C3  1 
HETATM 8420 C C4  . BU1 G 4 .   ? -72.367 5.979   -52.296  1.00 67.95  ? 101  BU1 F C4  1 
HETATM 8421 O O5  . BU1 G 4 .   ? -74.074 8.129   -54.513  1.00 34.54  ? 101  BU1 F O5  1 
HETATM 8422 O O6  . BU1 G 4 .   ? -71.429 5.049   -51.828  1.00 52.00  ? 101  BU1 F O6  1 
HETATM 8423 C C1  . BU1 H 4 .   ? -67.408 9.829   -55.049  1.00 64.99  ? 301  BU1 B C1  1 
HETATM 8424 C C2  . BU1 H 4 .   ? -66.309 10.572  -54.290  1.00 57.98  ? 301  BU1 B C2  1 
HETATM 8425 C C3  . BU1 H 4 .   ? -65.813 9.696   -53.140  1.00 64.97  ? 301  BU1 B C3  1 
HETATM 8426 C C4  . BU1 H 4 .   ? -64.647 8.822   -53.594  1.00 62.17  ? 301  BU1 B C4  1 
HETATM 8427 O O5  . BU1 H 4 .   ? -68.668 10.220  -54.571  1.00 48.68  ? 301  BU1 B O5  1 
HETATM 8428 O O6  . BU1 H 4 .   ? -63.993 8.292   -52.473  1.00 59.36  ? 301  BU1 B O6  1 
HETATM 8429 C C1  . BU1 I 4 .   ? -53.817 4.622   -67.608  1.00 71.38  ? 302  BU1 B C1  1 
HETATM 8430 C C2  . BU1 I 4 .   ? -53.144 4.135   -66.320  1.00 89.79  ? 302  BU1 B C2  1 
HETATM 8431 C C3  . BU1 I 4 .   ? -52.884 2.631   -66.421  1.00 84.79  ? 302  BU1 B C3  1 
HETATM 8432 C C4  . BU1 I 4 .   ? -51.869 2.193   -65.366  1.00 84.99  ? 302  BU1 B C4  1 
HETATM 8433 O O5  . BU1 I 4 .   ? -54.934 5.413   -67.303  1.00 69.47  ? 302  BU1 B O5  1 
HETATM 8434 O O6  . BU1 I 4 .   ? -52.495 2.112   -64.116  1.00 73.80  ? 302  BU1 B O6  1 
HETATM 8435 C C1  . BU1 J 4 .   ? -65.823 9.100   -99.120  1.00 42.41  ? 1601 BU1 A C1  1 
HETATM 8436 C C2  . BU1 J 4 .   ? -65.387 9.472   -100.536 1.00 53.08  ? 1601 BU1 A C2  1 
HETATM 8437 C C3  . BU1 J 4 .   ? -66.530 9.201   -101.513 1.00 52.87  ? 1601 BU1 A C3  1 
HETATM 8438 C C4  . BU1 J 4 .   ? -66.517 7.731   -101.935 1.00 42.60  ? 1601 BU1 A C4  1 
HETATM 8439 O O5  . BU1 J 4 .   ? -64.928 8.155   -98.604  1.00 45.55  ? 1601 BU1 A O5  1 
HETATM 8440 O O6  . BU1 J 4 .   ? -67.180 6.947   -100.979 1.00 47.09  ? 1601 BU1 A O6  1 
HETATM 8441 C C1  . BU1 K 4 .   ? -71.423 43.999  -50.808  1.00 68.41  ? 1602 BU1 A C1  1 
HETATM 8442 C C2  . BU1 K 4 .   ? -70.107 43.571  -50.161  1.00 73.87  ? 1602 BU1 A C2  1 
HETATM 8443 C C3  . BU1 K 4 .   ? -69.057 44.657  -50.386  1.00 69.45  ? 1602 BU1 A C3  1 
HETATM 8444 C C4  . BU1 K 4 .   ? -68.933 45.523  -49.134  1.00 82.94  ? 1602 BU1 A C4  1 
HETATM 8445 O O5  . BU1 K 4 .   ? -71.992 42.911  -51.484  1.00 73.32  ? 1602 BU1 A O5  1 
HETATM 8446 O O6  . BU1 K 4 .   ? -68.405 46.775  -49.480  1.00 59.26  ? 1602 BU1 A O6  1 
HETATM 8447 C C1  . BU1 L 4 .   ? -31.967 47.589  -93.291  1.00 70.36  ? 301  BU1 C C1  1 
HETATM 8448 C C2  . BU1 L 4 .   ? -33.265 48.234  -93.765  1.00 63.76  ? 301  BU1 C C2  1 
HETATM 8449 C C3  . BU1 L 4 .   ? -32.952 49.617  -94.330  1.00 80.58  ? 301  BU1 C C3  1 
HETATM 8450 C C4  . BU1 L 4 .   ? -34.229 50.254  -94.872  1.00 77.00  ? 301  BU1 C C4  1 
HETATM 8451 O O5  . BU1 L 4 .   ? -31.327 48.452  -92.391  1.00 79.22  ? 301  BU1 C O5  1 
HETATM 8452 O O6  . BU1 L 4 .   ? -34.427 49.837  -96.196  1.00 84.69  ? 301  BU1 C O6  1 
HETATM 8453 O O   . HOH M 5 .   ? -24.177 33.931  -97.987  1.00 42.01  ? 101  HOH G O   1 
HETATM 8454 O O   . HOH M 5 .   ? -31.857 49.349  -98.143  1.00 36.96  ? 102  HOH G O   1 
HETATM 8455 O O   . HOH M 5 .   ? -42.542 47.925  -109.801 1.00 37.83  ? 103  HOH G O   1 
HETATM 8456 O O   . HOH N 5 .   ? -45.892 7.569   -55.281  1.00 48.06  ? 401  HOH B O   1 
HETATM 8457 O O   . HOH N 5 .   ? -51.255 24.231  -23.779  1.00 32.18  ? 402  HOH B O   1 
HETATM 8458 O O   . HOH N 5 .   ? -35.257 10.408  -41.736  1.00 31.02  ? 403  HOH B O   1 
HETATM 8459 O O   . HOH N 5 .   ? -65.273 -1.429  -71.581  1.00 32.05  ? 404  HOH B O   1 
HETATM 8460 O O   . HOH O 5 .   ? -65.072 54.498  -48.253  1.00 56.19  ? 1701 HOH A O   1 
HETATM 8461 O O   . HOH O 5 .   ? -76.758 37.049  -66.519  1.00 50.23  ? 1702 HOH A O   1 
HETATM 8462 O O   . HOH O 5 .   ? -54.208 16.033  -77.044  1.00 54.01  ? 1703 HOH A O   1 
HETATM 8463 O O   . HOH O 5 .   ? -62.444 -2.168  -71.962  1.00 48.82  ? 1704 HOH A O   1 
HETATM 8464 O O   . HOH O 5 .   ? -63.271 6.907   -102.269 1.00 39.48  ? 1705 HOH A O   1 
HETATM 8465 O O   . HOH O 5 .   ? -72.942 20.647  -82.657  1.00 38.54  ? 1706 HOH A O   1 
HETATM 8466 O O   . HOH O 5 .   ? -85.241 32.786  -78.036  1.00 47.49  ? 1707 HOH A O   1 
HETATM 8467 O O   . HOH O 5 .   ? -80.235 50.436  -69.860  1.00 41.52  ? 1708 HOH A O   1 
HETATM 8468 O O   . HOH O 5 .   ? -51.177 24.705  -80.318  1.00 44.87  ? 1709 HOH A O   1 
HETATM 8469 O O   . HOH O 5 .   ? -73.562 46.943  -73.721  1.00 27.49  ? 1710 HOH A O   1 
HETATM 8470 O O   . HOH O 5 .   ? -69.224 48.636  -76.319  1.00 41.08  ? 1711 HOH A O   1 
HETATM 8471 O O   . HOH O 5 .   ? -77.959 36.664  -76.468  1.00 55.04  ? 1712 HOH A O   1 
HETATM 8472 O O   . HOH O 5 .   ? -80.365 58.227  -53.775  1.00 46.25  ? 1713 HOH A O   1 
HETATM 8473 O O   . HOH O 5 .   ? -63.025 50.724  -73.628  1.00 35.64  ? 1714 HOH A O   1 
HETATM 8474 O O   . HOH O 5 .   ? -63.732 -3.704  -73.204  1.00 59.89  ? 1715 HOH A O   1 
HETATM 8475 O O   . HOH O 5 .   ? -56.897 1.005   -79.767  1.00 32.34  ? 1716 HOH A O   1 
HETATM 8476 O O   . HOH O 5 .   ? -63.422 53.386  -68.186  1.00 36.06  ? 1717 HOH A O   1 
HETATM 8477 O O   . HOH O 5 .   ? -74.210 9.061   -75.777  1.00 40.39  ? 1718 HOH A O   1 
HETATM 8478 O O   . HOH O 5 .   ? -79.046 49.531  -71.782  1.00 52.43  ? 1719 HOH A O   1 
HETATM 8479 O O   . HOH O 5 .   ? -79.706 51.097  -66.653  1.00 43.44  ? 1720 HOH A O   1 
HETATM 8480 O O   . HOH O 5 .   ? -82.713 30.848  -82.016  1.00 50.46  ? 1721 HOH A O   1 
HETATM 8481 O O   . HOH O 5 .   ? -52.575 31.125  -74.431  1.00 26.60  ? 1722 HOH A O   1 
HETATM 8482 O O   . HOH O 5 .   ? -84.827 41.590  -65.997  1.00 25.09  ? 1723 HOH A O   1 
HETATM 8483 O O   . HOH O 5 .   ? -61.227 58.098  -70.755  1.00 41.43  ? 1724 HOH A O   1 
HETATM 8484 O O   . HOH P 5 .   ? -52.128 35.637  -76.065  1.00 48.73  ? 401  HOH C O   1 
HETATM 8485 O O   . HOH P 5 .   ? -35.068 29.292  -96.167  1.00 49.35  ? 402  HOH C O   1 
HETATM 8486 O O   . HOH P 5 .   ? -29.026 14.840  -85.932  1.00 36.85  ? 403  HOH C O   1 
HETATM 8487 O O   . HOH P 5 .   ? -24.025 44.915  -82.604  1.00 35.07  ? 404  HOH C O   1 
HETATM 8488 O O   . HOH P 5 .   ? -38.204 34.635  -95.808  1.00 37.26  ? 405  HOH C O   1 
HETATM 8489 O O   . HOH P 5 .   ? -59.113 63.648  -85.497  1.00 42.53  ? 406  HOH C O   1 
HETATM 8490 O O   . HOH P 5 .   ? -28.998 33.610  -96.295  1.00 10.93  ? 407  HOH C O   1 
HETATM 8491 O O   . HOH P 5 .   ? -58.504 33.326  -96.905  1.00 44.07  ? 408  HOH C O   1 
HETATM 8492 O O   . HOH P 5 .   ? -42.672 35.520  -76.824  1.00 28.58  ? 409  HOH C O   1 
HETATM 8493 O O   . HOH P 5 .   ? -59.877 65.652  -87.427  1.00 44.98  ? 410  HOH C O   1 
HETATM 8494 O O   . HOH P 5 .   ? -22.166 23.738  -106.294 1.00 43.41  ? 411  HOH C O   1 
HETATM 8495 O O   . HOH P 5 .   ? -55.694 64.253  -108.306 1.00 29.81  ? 412  HOH C O   1 
HETATM 8496 O O   . HOH P 5 .   ? -53.777 64.608  -82.939  1.00 41.89  ? 413  HOH C O   1 
HETATM 8497 O O   . HOH P 5 .   ? -52.549 64.490  -78.436  1.00 24.67  ? 414  HOH C O   1 
HETATM 8498 O O   . HOH Q 5 .   ? -36.254 21.031  -64.766  1.00 50.65  ? 1601 HOH D O   1 
# 
