data_9FKH
# 
_entry.id   9FKH 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FKH         pdb_00009fkh 10.2210/pdb9fkh/pdb 
WWPDB D_1292139082 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FKH 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          Shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Chmelnik, O.' 2 ? 
'Dessau, M.'   3 ? 
'Shoham, Y.'   4 ? 
'Shoham, G.'   5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'The structure of glycosynthase IXT6 (E241G mutant), the intracellular xylanase of G.proteiniphilus T-6' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Chmelnik, O.' 2 ? 
primary 'Dessau, M.'   3 ? 
primary 'Shoham, Y.'   4 ? 
primary 'Shoham, G.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Beta-xylanase 38622.805 2   3.2.1.8 ? ? ? 
2 water   nat water         18.015    541 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNSSLPSLRDVFANDFRIGAAVNPVTIEMQKQLLIDHVNSITAENHMKFEHLQPEEGKFTFQEADRIVDFACSHRMAVRG
HTLVWHNQTPDWVFQDGQGHFVSRDVLLERMKCHISTVVRRYKGKIYCWDVINEAVADEGNELLRPSKWRQIIGDDFMEQ
AFLYAYEADPDALLFYNDYNECFPEKREKIFALVKSLRDKGIPIHGIGMQAHWSLTRPSLDEIRAAIERYASLGVVLHIT
GLDVSMFEFHDRRTDLAAPTSEMIERQAERYGQIFALFKEYRDVIQSVTFWGIADDHTWLDNFPVHGRKNWPLLFDEQHK
PKPAFWRAVSV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNSSLPSLRDVFANDFRIGAAVNPVTIEMQKQLLIDHVNSITAENHMKFEHLQPEEGKFTFQEADRIVDFACSHRMAVRG
HTLVWHNQTPDWVFQDGQGHFVSRDVLLERMKCHISTVVRRYKGKIYCWDVINEAVADEGNELLRPSKWRQIIGDDFMEQ
AFLYAYEADPDALLFYNDYNECFPEKREKIFALVKSLRDKGIPIHGIGMQAHWSLTRPSLDEIRAAIERYASLGVVLHIT
GLDVSMFEFHDRRTDLAAPTSEMIERQAERYGQIFALFKEYRDVIQSVTFWGIADDHTWLDNFPVHGRKNWPLLFDEQHK
PKPAFWRAVSV
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   SER n 
1 4   SER n 
1 5   LEU n 
1 6   PRO n 
1 7   SER n 
1 8   LEU n 
1 9   ARG n 
1 10  ASP n 
1 11  VAL n 
1 12  PHE n 
1 13  ALA n 
1 14  ASN n 
1 15  ASP n 
1 16  PHE n 
1 17  ARG n 
1 18  ILE n 
1 19  GLY n 
1 20  ALA n 
1 21  ALA n 
1 22  VAL n 
1 23  ASN n 
1 24  PRO n 
1 25  VAL n 
1 26  THR n 
1 27  ILE n 
1 28  GLU n 
1 29  MET n 
1 30  GLN n 
1 31  LYS n 
1 32  GLN n 
1 33  LEU n 
1 34  LEU n 
1 35  ILE n 
1 36  ASP n 
1 37  HIS n 
1 38  VAL n 
1 39  ASN n 
1 40  SER n 
1 41  ILE n 
1 42  THR n 
1 43  ALA n 
1 44  GLU n 
1 45  ASN n 
1 46  HIS n 
1 47  MET n 
1 48  LYS n 
1 49  PHE n 
1 50  GLU n 
1 51  HIS n 
1 52  LEU n 
1 53  GLN n 
1 54  PRO n 
1 55  GLU n 
1 56  GLU n 
1 57  GLY n 
1 58  LYS n 
1 59  PHE n 
1 60  THR n 
1 61  PHE n 
1 62  GLN n 
1 63  GLU n 
1 64  ALA n 
1 65  ASP n 
1 66  ARG n 
1 67  ILE n 
1 68  VAL n 
1 69  ASP n 
1 70  PHE n 
1 71  ALA n 
1 72  CYS n 
1 73  SER n 
1 74  HIS n 
1 75  ARG n 
1 76  MET n 
1 77  ALA n 
1 78  VAL n 
1 79  ARG n 
1 80  GLY n 
1 81  HIS n 
1 82  THR n 
1 83  LEU n 
1 84  VAL n 
1 85  TRP n 
1 86  HIS n 
1 87  ASN n 
1 88  GLN n 
1 89  THR n 
1 90  PRO n 
1 91  ASP n 
1 92  TRP n 
1 93  VAL n 
1 94  PHE n 
1 95  GLN n 
1 96  ASP n 
1 97  GLY n 
1 98  GLN n 
1 99  GLY n 
1 100 HIS n 
1 101 PHE n 
1 102 VAL n 
1 103 SER n 
1 104 ARG n 
1 105 ASP n 
1 106 VAL n 
1 107 LEU n 
1 108 LEU n 
1 109 GLU n 
1 110 ARG n 
1 111 MET n 
1 112 LYS n 
1 113 CYS n 
1 114 HIS n 
1 115 ILE n 
1 116 SER n 
1 117 THR n 
1 118 VAL n 
1 119 VAL n 
1 120 ARG n 
1 121 ARG n 
1 122 TYR n 
1 123 LYS n 
1 124 GLY n 
1 125 LYS n 
1 126 ILE n 
1 127 TYR n 
1 128 CYS n 
1 129 TRP n 
1 130 ASP n 
1 131 VAL n 
1 132 ILE n 
1 133 ASN n 
1 134 GLU n 
1 135 ALA n 
1 136 VAL n 
1 137 ALA n 
1 138 ASP n 
1 139 GLU n 
1 140 GLY n 
1 141 ASN n 
1 142 GLU n 
1 143 LEU n 
1 144 LEU n 
1 145 ARG n 
1 146 PRO n 
1 147 SER n 
1 148 LYS n 
1 149 TRP n 
1 150 ARG n 
1 151 GLN n 
1 152 ILE n 
1 153 ILE n 
1 154 GLY n 
1 155 ASP n 
1 156 ASP n 
1 157 PHE n 
1 158 MET n 
1 159 GLU n 
1 160 GLN n 
1 161 ALA n 
1 162 PHE n 
1 163 LEU n 
1 164 TYR n 
1 165 ALA n 
1 166 TYR n 
1 167 GLU n 
1 168 ALA n 
1 169 ASP n 
1 170 PRO n 
1 171 ASP n 
1 172 ALA n 
1 173 LEU n 
1 174 LEU n 
1 175 PHE n 
1 176 TYR n 
1 177 ASN n 
1 178 ASP n 
1 179 TYR n 
1 180 ASN n 
1 181 GLU n 
1 182 CYS n 
1 183 PHE n 
1 184 PRO n 
1 185 GLU n 
1 186 LYS n 
1 187 ARG n 
1 188 GLU n 
1 189 LYS n 
1 190 ILE n 
1 191 PHE n 
1 192 ALA n 
1 193 LEU n 
1 194 VAL n 
1 195 LYS n 
1 196 SER n 
1 197 LEU n 
1 198 ARG n 
1 199 ASP n 
1 200 LYS n 
1 201 GLY n 
1 202 ILE n 
1 203 PRO n 
1 204 ILE n 
1 205 HIS n 
1 206 GLY n 
1 207 ILE n 
1 208 GLY n 
1 209 MET n 
1 210 GLN n 
1 211 ALA n 
1 212 HIS n 
1 213 TRP n 
1 214 SER n 
1 215 LEU n 
1 216 THR n 
1 217 ARG n 
1 218 PRO n 
1 219 SER n 
1 220 LEU n 
1 221 ASP n 
1 222 GLU n 
1 223 ILE n 
1 224 ARG n 
1 225 ALA n 
1 226 ALA n 
1 227 ILE n 
1 228 GLU n 
1 229 ARG n 
1 230 TYR n 
1 231 ALA n 
1 232 SER n 
1 233 LEU n 
1 234 GLY n 
1 235 VAL n 
1 236 VAL n 
1 237 LEU n 
1 238 HIS n 
1 239 ILE n 
1 240 THR n 
1 241 GLY n 
1 242 LEU n 
1 243 ASP n 
1 244 VAL n 
1 245 SER n 
1 246 MET n 
1 247 PHE n 
1 248 GLU n 
1 249 PHE n 
1 250 HIS n 
1 251 ASP n 
1 252 ARG n 
1 253 ARG n 
1 254 THR n 
1 255 ASP n 
1 256 LEU n 
1 257 ALA n 
1 258 ALA n 
1 259 PRO n 
1 260 THR n 
1 261 SER n 
1 262 GLU n 
1 263 MET n 
1 264 ILE n 
1 265 GLU n 
1 266 ARG n 
1 267 GLN n 
1 268 ALA n 
1 269 GLU n 
1 270 ARG n 
1 271 TYR n 
1 272 GLY n 
1 273 GLN n 
1 274 ILE n 
1 275 PHE n 
1 276 ALA n 
1 277 LEU n 
1 278 PHE n 
1 279 LYS n 
1 280 GLU n 
1 281 TYR n 
1 282 ARG n 
1 283 ASP n 
1 284 VAL n 
1 285 ILE n 
1 286 GLN n 
1 287 SER n 
1 288 VAL n 
1 289 THR n 
1 290 PHE n 
1 291 TRP n 
1 292 GLY n 
1 293 ILE n 
1 294 ALA n 
1 295 ASP n 
1 296 ASP n 
1 297 HIS n 
1 298 THR n 
1 299 TRP n 
1 300 LEU n 
1 301 ASP n 
1 302 ASN n 
1 303 PHE n 
1 304 PRO n 
1 305 VAL n 
1 306 HIS n 
1 307 GLY n 
1 308 ARG n 
1 309 LYS n 
1 310 ASN n 
1 311 TRP n 
1 312 PRO n 
1 313 LEU n 
1 314 LEU n 
1 315 PHE n 
1 316 ASP n 
1 317 GLU n 
1 318 GLN n 
1 319 HIS n 
1 320 LYS n 
1 321 PRO n 
1 322 LYS n 
1 323 PRO n 
1 324 ALA n 
1 325 PHE n 
1 326 TRP n 
1 327 ARG n 
1 328 ALA n 
1 329 VAL n 
1 330 SER n 
1 331 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   331 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 xynA2 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus proteiniphilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     860353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   3   SER SER A . n 
A 1 4   SER 4   4   4   SER SER A . n 
A 1 5   LEU 5   5   5   LEU LEU A . n 
A 1 6   PRO 6   6   6   PRO PRO A . n 
A 1 7   SER 7   7   7   SER SER A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  ASP 10  10  10  ASP ASP A . n 
A 1 11  VAL 11  11  11  VAL VAL A . n 
A 1 12  PHE 12  12  12  PHE PHE A . n 
A 1 13  ALA 13  13  13  ALA ALA A . n 
A 1 14  ASN 14  14  14  ASN ASN A . n 
A 1 15  ASP 15  15  15  ASP ASP A . n 
A 1 16  PHE 16  16  16  PHE PHE A . n 
A 1 17  ARG 17  17  17  ARG ARG A . n 
A 1 18  ILE 18  18  18  ILE ILE A . n 
A 1 19  GLY 19  19  19  GLY GLY A . n 
A 1 20  ALA 20  20  20  ALA ALA A . n 
A 1 21  ALA 21  21  21  ALA ALA A . n 
A 1 22  VAL 22  22  22  VAL VAL A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  PRO 24  24  24  PRO PRO A . n 
A 1 25  VAL 25  25  25  VAL VAL A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  ILE 27  27  27  ILE ILE A . n 
A 1 28  GLU 28  28  28  GLU GLU A . n 
A 1 29  MET 29  29  29  MET MET A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  LYS 31  31  31  LYS LYS A . n 
A 1 32  GLN 32  32  32  GLN GLN A . n 
A 1 33  LEU 33  33  33  LEU LEU A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ILE 35  35  35  ILE ILE A . n 
A 1 36  ASP 36  36  36  ASP ASP A . n 
A 1 37  HIS 37  37  37  HIS HIS A . n 
A 1 38  VAL 38  38  38  VAL VAL A . n 
A 1 39  ASN 39  39  39  ASN ASN A . n 
A 1 40  SER 40  40  40  SER SER A . n 
A 1 41  ILE 41  41  41  ILE ILE A . n 
A 1 42  THR 42  42  42  THR THR A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  GLU 44  44  44  GLU GLU A . n 
A 1 45  ASN 45  45  45  ASN ASN A . n 
A 1 46  HIS 46  46  46  HIS HIS A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  LYS 48  48  48  LYS LYS A . n 
A 1 49  PHE 49  49  49  PHE PHE A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  LEU 52  52  52  LEU LEU A . n 
A 1 53  GLN 53  53  53  GLN GLN A . n 
A 1 54  PRO 54  54  54  PRO PRO A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  GLU 56  56  56  GLU GLU A . n 
A 1 57  GLY 57  57  57  GLY GLY A . n 
A 1 58  LYS 58  58  58  LYS LYS A . n 
A 1 59  PHE 59  59  59  PHE PHE A . n 
A 1 60  THR 60  60  60  THR THR A . n 
A 1 61  PHE 61  61  61  PHE PHE A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  ASP 65  65  65  ASP ASP A . n 
A 1 66  ARG 66  66  66  ARG ARG A . n 
A 1 67  ILE 67  67  67  ILE ILE A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  ASP 69  69  69  ASP ASP A . n 
A 1 70  PHE 70  70  70  PHE PHE A . n 
A 1 71  ALA 71  71  71  ALA ALA A . n 
A 1 72  CYS 72  72  72  CYS CYS A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  HIS 74  74  74  HIS HIS A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  MET 76  76  76  MET MET A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  HIS 81  81  81  HIS HIS A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  VAL 84  84  84  VAL VAL A . n 
A 1 85  TRP 85  85  85  TRP TRP A . n 
A 1 86  HIS 86  86  86  HIS HIS A . n 
A 1 87  ASN 87  87  87  ASN ASN A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  TRP 92  92  92  TRP TRP A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  GLN 95  95  95  GLN GLN A . n 
A 1 96  ASP 96  96  96  ASP ASP A . n 
A 1 97  GLY 97  97  97  GLY GLY A . n 
A 1 98  GLN 98  98  98  GLN GLN A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 HIS 100 100 100 HIS HIS A . n 
A 1 101 PHE 101 101 101 PHE PHE A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 ARG 104 104 104 ARG ARG A . n 
A 1 105 ASP 105 105 105 ASP ASP A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 LEU 107 107 107 LEU LEU A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ARG 110 110 110 ARG ARG A . n 
A 1 111 MET 111 111 111 MET MET A . n 
A 1 112 LYS 112 112 112 LYS LYS A . n 
A 1 113 CYS 113 113 113 CYS CYS A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 ILE 115 115 115 ILE ILE A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 ARG 121 121 121 ARG ARG A . n 
A 1 122 TYR 122 122 122 TYR TYR A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 LYS 125 125 125 LYS LYS A . n 
A 1 126 ILE 126 126 126 ILE ILE A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 TRP 129 129 129 TRP TRP A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 VAL 131 131 131 VAL VAL A . n 
A 1 132 ILE 132 132 132 ILE ILE A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 GLU 134 134 134 GLU GLU A . n 
A 1 135 ALA 135 135 135 ALA ALA A . n 
A 1 136 VAL 136 136 136 VAL VAL A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 ASP 138 138 138 ASP ASP A . n 
A 1 139 GLU 139 139 139 GLU GLU A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 GLU 142 142 142 GLU GLU A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 LEU 144 144 144 LEU LEU A . n 
A 1 145 ARG 145 145 145 ARG ARG A . n 
A 1 146 PRO 146 146 146 PRO PRO A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 TRP 149 149 149 TRP TRP A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 GLN 151 151 151 GLN GLN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ILE 153 153 153 ILE ILE A . n 
A 1 154 GLY 154 154 154 GLY GLY A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 PHE 157 157 157 PHE PHE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 PHE 162 162 162 PHE PHE A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 TYR 164 164 164 TYR TYR A . n 
A 1 165 ALA 165 165 165 ALA ALA A . n 
A 1 166 TYR 166 166 166 TYR TYR A . n 
A 1 167 GLU 167 167 167 GLU GLU A . n 
A 1 168 ALA 168 168 168 ALA ALA A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 PRO 170 170 170 PRO PRO A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 PHE 175 175 175 PHE PHE A . n 
A 1 176 TYR 176 176 176 TYR TYR A . n 
A 1 177 ASN 177 177 177 ASN ASN A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 TYR 179 179 179 TYR TYR A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 GLU 181 181 181 GLU GLU A . n 
A 1 182 CYS 182 182 182 CYS CYS A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 LYS 186 186 186 LYS LYS A . n 
A 1 187 ARG 187 187 187 ARG ARG A . n 
A 1 188 GLU 188 188 188 GLU GLU A . n 
A 1 189 LYS 189 189 189 LYS LYS A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 LEU 193 193 193 LEU LEU A . n 
A 1 194 VAL 194 194 194 VAL VAL A . n 
A 1 195 LYS 195 195 195 LYS LYS A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 LEU 197 197 197 LEU LEU A . n 
A 1 198 ARG 198 198 198 ARG ARG A . n 
A 1 199 ASP 199 199 199 ASP ASP A . n 
A 1 200 LYS 200 200 200 LYS LYS A . n 
A 1 201 GLY 201 201 201 GLY GLY A . n 
A 1 202 ILE 202 202 202 ILE ILE A . n 
A 1 203 PRO 203 203 203 PRO PRO A . n 
A 1 204 ILE 204 204 204 ILE ILE A . n 
A 1 205 HIS 205 205 205 HIS HIS A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 ILE 207 207 207 ILE ILE A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 MET 209 209 209 MET MET A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 HIS 212 212 212 HIS HIS A . n 
A 1 213 TRP 213 213 213 TRP TRP A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 THR 216 216 216 THR THR A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 PRO 218 218 218 PRO PRO A . n 
A 1 219 SER 219 219 219 SER SER A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 GLU 222 222 222 GLU GLU A . n 
A 1 223 ILE 223 223 223 ILE ILE A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 ALA 225 225 225 ALA ALA A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 ILE 227 227 227 ILE ILE A . n 
A 1 228 GLU 228 228 228 GLU GLU A . n 
A 1 229 ARG 229 229 229 ARG ARG A . n 
A 1 230 TYR 230 230 230 TYR TYR A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 SER 232 232 232 SER SER A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 GLY 234 234 234 GLY GLY A . n 
A 1 235 VAL 235 235 235 VAL VAL A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 HIS 238 238 238 HIS HIS A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 THR 240 240 240 THR THR A . n 
A 1 241 GLY 241 241 241 GLY GLY A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 ASP 243 243 243 ASP ASP A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 SER 245 245 245 SER SER A . n 
A 1 246 MET 246 246 246 MET MET A . n 
A 1 247 PHE 247 247 247 PHE PHE A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 HIS 250 250 250 HIS HIS A . n 
A 1 251 ASP 251 251 251 ASP ASP A . n 
A 1 252 ARG 252 252 252 ARG ARG A . n 
A 1 253 ARG 253 253 253 ARG ARG A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 ASP 255 255 255 ASP ASP A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 ALA 257 257 257 ALA ALA A . n 
A 1 258 ALA 258 258 258 ALA ALA A . n 
A 1 259 PRO 259 259 259 PRO PRO A . n 
A 1 260 THR 260 260 260 THR THR A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 GLU 262 262 262 GLU GLU A . n 
A 1 263 MET 263 263 263 MET MET A . n 
A 1 264 ILE 264 264 264 ILE ILE A . n 
A 1 265 GLU 265 265 265 GLU GLU A . n 
A 1 266 ARG 266 266 266 ARG ARG A . n 
A 1 267 GLN 267 267 267 GLN GLN A . n 
A 1 268 ALA 268 268 268 ALA ALA A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ILE 274 274 274 ILE ILE A . n 
A 1 275 PHE 275 275 275 PHE PHE A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 PHE 278 278 278 PHE PHE A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ARG 282 282 282 ARG ARG A . n 
A 1 283 ASP 283 283 283 ASP ASP A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 ILE 285 285 285 ILE ILE A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 SER 287 287 287 SER SER A . n 
A 1 288 VAL 288 288 288 VAL VAL A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 TRP 291 291 291 TRP TRP A . n 
A 1 292 GLY 292 292 292 GLY GLY A . n 
A 1 293 ILE 293 293 293 ILE ILE A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 ASP 296 296 296 ASP ASP A . n 
A 1 297 HIS 297 297 297 HIS HIS A . n 
A 1 298 THR 298 298 298 THR THR A . n 
A 1 299 TRP 299 299 299 TRP TRP A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ASP 301 301 301 ASP ASP A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 PHE 303 303 303 PHE PHE A . n 
A 1 304 PRO 304 304 304 PRO PRO A . n 
A 1 305 VAL 305 305 305 VAL VAL A . n 
A 1 306 HIS 306 306 306 HIS HIS A . n 
A 1 307 GLY 307 307 307 GLY GLY A . n 
A 1 308 ARG 308 308 308 ARG ARG A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ASN 310 310 310 ASN ASN A . n 
A 1 311 TRP 311 311 311 TRP TRP A . n 
A 1 312 PRO 312 312 312 PRO PRO A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 ASP 316 316 316 ASP ASP A . n 
A 1 317 GLU 317 317 317 GLU GLU A . n 
A 1 318 GLN 318 318 318 GLN GLN A . n 
A 1 319 HIS 319 319 319 HIS HIS A . n 
A 1 320 LYS 320 320 320 LYS LYS A . n 
A 1 321 PRO 321 321 321 PRO PRO A . n 
A 1 322 LYS 322 322 322 LYS LYS A . n 
A 1 323 PRO 323 323 323 PRO PRO A . n 
A 1 324 ALA 324 324 324 ALA ALA A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 TRP 326 326 326 TRP TRP A . n 
A 1 327 ARG 327 327 327 ARG ARG A . n 
A 1 328 ALA 328 328 328 ALA ALA A . n 
A 1 329 VAL 329 329 329 VAL VAL A . n 
A 1 330 SER 330 330 330 SER SER A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ASN 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   SER 4   4   4   SER SER B . n 
B 1 5   LEU 5   5   5   LEU LEU B . n 
B 1 6   PRO 6   6   6   PRO PRO B . n 
B 1 7   SER 7   7   7   SER SER B . n 
B 1 8   LEU 8   8   8   LEU LEU B . n 
B 1 9   ARG 9   9   9   ARG ARG B . n 
B 1 10  ASP 10  10  10  ASP ASP B . n 
B 1 11  VAL 11  11  11  VAL VAL B . n 
B 1 12  PHE 12  12  12  PHE PHE B . n 
B 1 13  ALA 13  13  13  ALA ALA B . n 
B 1 14  ASN 14  14  14  ASN ASN B . n 
B 1 15  ASP 15  15  15  ASP ASP B . n 
B 1 16  PHE 16  16  16  PHE PHE B . n 
B 1 17  ARG 17  17  17  ARG ARG B . n 
B 1 18  ILE 18  18  18  ILE ILE B . n 
B 1 19  GLY 19  19  19  GLY GLY B . n 
B 1 20  ALA 20  20  20  ALA ALA B . n 
B 1 21  ALA 21  21  21  ALA ALA B . n 
B 1 22  VAL 22  22  22  VAL VAL B . n 
B 1 23  ASN 23  23  23  ASN ASN B . n 
B 1 24  PRO 24  24  24  PRO PRO B . n 
B 1 25  VAL 25  25  25  VAL VAL B . n 
B 1 26  THR 26  26  26  THR THR B . n 
B 1 27  ILE 27  27  27  ILE ILE B . n 
B 1 28  GLU 28  28  28  GLU GLU B . n 
B 1 29  MET 29  29  29  MET MET B . n 
B 1 30  GLN 30  30  30  GLN GLN B . n 
B 1 31  LYS 31  31  31  LYS LYS B . n 
B 1 32  GLN 32  32  32  GLN GLN B . n 
B 1 33  LEU 33  33  33  LEU LEU B . n 
B 1 34  LEU 34  34  34  LEU LEU B . n 
B 1 35  ILE 35  35  35  ILE ILE B . n 
B 1 36  ASP 36  36  36  ASP ASP B . n 
B 1 37  HIS 37  37  37  HIS HIS B . n 
B 1 38  VAL 38  38  38  VAL VAL B . n 
B 1 39  ASN 39  39  39  ASN ASN B . n 
B 1 40  SER 40  40  40  SER SER B . n 
B 1 41  ILE 41  41  41  ILE ILE B . n 
B 1 42  THR 42  42  42  THR THR B . n 
B 1 43  ALA 43  43  43  ALA ALA B . n 
B 1 44  GLU 44  44  44  GLU GLU B . n 
B 1 45  ASN 45  45  45  ASN ASN B . n 
B 1 46  HIS 46  46  46  HIS HIS B . n 
B 1 47  MET 47  47  47  MET MET B . n 
B 1 48  LYS 48  48  48  LYS LYS B . n 
B 1 49  PHE 49  49  49  PHE PHE B . n 
B 1 50  GLU 50  50  50  GLU GLU B . n 
B 1 51  HIS 51  51  51  HIS HIS B . n 
B 1 52  LEU 52  52  52  LEU LEU B . n 
B 1 53  GLN 53  53  53  GLN GLN B . n 
B 1 54  PRO 54  54  54  PRO PRO B . n 
B 1 55  GLU 55  55  55  GLU GLU B . n 
B 1 56  GLU 56  56  56  GLU GLU B . n 
B 1 57  GLY 57  57  57  GLY GLY B . n 
B 1 58  LYS 58  58  58  LYS LYS B . n 
B 1 59  PHE 59  59  59  PHE PHE B . n 
B 1 60  THR 60  60  60  THR THR B . n 
B 1 61  PHE 61  61  61  PHE PHE B . n 
B 1 62  GLN 62  62  62  GLN GLN B . n 
B 1 63  GLU 63  63  63  GLU GLU B . n 
B 1 64  ALA 64  64  64  ALA ALA B . n 
B 1 65  ASP 65  65  65  ASP ASP B . n 
B 1 66  ARG 66  66  66  ARG ARG B . n 
B 1 67  ILE 67  67  67  ILE ILE B . n 
B 1 68  VAL 68  68  68  VAL VAL B . n 
B 1 69  ASP 69  69  69  ASP ASP B . n 
B 1 70  PHE 70  70  70  PHE PHE B . n 
B 1 71  ALA 71  71  71  ALA ALA B . n 
B 1 72  CYS 72  72  72  CYS CYS B . n 
B 1 73  SER 73  73  73  SER SER B . n 
B 1 74  HIS 74  74  74  HIS HIS B . n 
B 1 75  ARG 75  75  75  ARG ARG B . n 
B 1 76  MET 76  76  76  MET MET B . n 
B 1 77  ALA 77  77  77  ALA ALA B . n 
B 1 78  VAL 78  78  78  VAL VAL B . n 
B 1 79  ARG 79  79  79  ARG ARG B . n 
B 1 80  GLY 80  80  80  GLY GLY B . n 
B 1 81  HIS 81  81  81  HIS HIS B . n 
B 1 82  THR 82  82  82  THR THR B . n 
B 1 83  LEU 83  83  83  LEU LEU B . n 
B 1 84  VAL 84  84  84  VAL VAL B . n 
B 1 85  TRP 85  85  85  TRP TRP B . n 
B 1 86  HIS 86  86  86  HIS HIS B . n 
B 1 87  ASN 87  87  87  ASN ASN B . n 
B 1 88  GLN 88  88  88  GLN GLN B . n 
B 1 89  THR 89  89  89  THR THR B . n 
B 1 90  PRO 90  90  90  PRO PRO B . n 
B 1 91  ASP 91  91  91  ASP ASP B . n 
B 1 92  TRP 92  92  92  TRP TRP B . n 
B 1 93  VAL 93  93  93  VAL VAL B . n 
B 1 94  PHE 94  94  94  PHE PHE B . n 
B 1 95  GLN 95  95  95  GLN GLN B . n 
B 1 96  ASP 96  96  96  ASP ASP B . n 
B 1 97  GLY 97  97  97  GLY GLY B . n 
B 1 98  GLN 98  98  98  GLN GLN B . n 
B 1 99  GLY 99  99  99  GLY GLY B . n 
B 1 100 HIS 100 100 100 HIS HIS B . n 
B 1 101 PHE 101 101 101 PHE PHE B . n 
B 1 102 VAL 102 102 102 VAL VAL B . n 
B 1 103 SER 103 103 103 SER SER B . n 
B 1 104 ARG 104 104 104 ARG ARG B . n 
B 1 105 ASP 105 105 105 ASP ASP B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 LEU 107 107 107 LEU LEU B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 GLU 109 109 109 GLU GLU B . n 
B 1 110 ARG 110 110 110 ARG ARG B . n 
B 1 111 MET 111 111 111 MET MET B . n 
B 1 112 LYS 112 112 112 LYS LYS B . n 
B 1 113 CYS 113 113 113 CYS CYS B . n 
B 1 114 HIS 114 114 114 HIS HIS B . n 
B 1 115 ILE 115 115 115 ILE ILE B . n 
B 1 116 SER 116 116 116 SER SER B . n 
B 1 117 THR 117 117 117 THR THR B . n 
B 1 118 VAL 118 118 118 VAL VAL B . n 
B 1 119 VAL 119 119 119 VAL VAL B . n 
B 1 120 ARG 120 120 120 ARG ARG B . n 
B 1 121 ARG 121 121 121 ARG ARG B . n 
B 1 122 TYR 122 122 122 TYR TYR B . n 
B 1 123 LYS 123 123 123 LYS LYS B . n 
B 1 124 GLY 124 124 124 GLY GLY B . n 
B 1 125 LYS 125 125 125 LYS LYS B . n 
B 1 126 ILE 126 126 126 ILE ILE B . n 
B 1 127 TYR 127 127 127 TYR TYR B . n 
B 1 128 CYS 128 128 128 CYS CYS B . n 
B 1 129 TRP 129 129 129 TRP TRP B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 VAL 131 131 131 VAL VAL B . n 
B 1 132 ILE 132 132 132 ILE ILE B . n 
B 1 133 ASN 133 133 133 ASN ASN B . n 
B 1 134 GLU 134 134 134 GLU GLU B . n 
B 1 135 ALA 135 135 135 ALA ALA B . n 
B 1 136 VAL 136 136 136 VAL VAL B . n 
B 1 137 ALA 137 137 137 ALA ALA B . n 
B 1 138 ASP 138 138 138 ASP ASP B . n 
B 1 139 GLU 139 139 139 GLU GLU B . n 
B 1 140 GLY 140 140 140 GLY GLY B . n 
B 1 141 ASN 141 141 141 ASN ASN B . n 
B 1 142 GLU 142 142 142 GLU GLU B . n 
B 1 143 LEU 143 143 143 LEU LEU B . n 
B 1 144 LEU 144 144 144 LEU LEU B . n 
B 1 145 ARG 145 145 145 ARG ARG B . n 
B 1 146 PRO 146 146 146 PRO PRO B . n 
B 1 147 SER 147 147 147 SER SER B . n 
B 1 148 LYS 148 148 148 LYS LYS B . n 
B 1 149 TRP 149 149 149 TRP TRP B . n 
B 1 150 ARG 150 150 150 ARG ARG B . n 
B 1 151 GLN 151 151 151 GLN GLN B . n 
B 1 152 ILE 152 152 152 ILE ILE B . n 
B 1 153 ILE 153 153 153 ILE ILE B . n 
B 1 154 GLY 154 154 154 GLY GLY B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 PHE 157 157 157 PHE PHE B . n 
B 1 158 MET 158 158 158 MET MET B . n 
B 1 159 GLU 159 159 159 GLU GLU B . n 
B 1 160 GLN 160 160 160 GLN GLN B . n 
B 1 161 ALA 161 161 161 ALA ALA B . n 
B 1 162 PHE 162 162 162 PHE PHE B . n 
B 1 163 LEU 163 163 163 LEU LEU B . n 
B 1 164 TYR 164 164 164 TYR TYR B . n 
B 1 165 ALA 165 165 165 ALA ALA B . n 
B 1 166 TYR 166 166 166 TYR TYR B . n 
B 1 167 GLU 167 167 167 GLU GLU B . n 
B 1 168 ALA 168 168 168 ALA ALA B . n 
B 1 169 ASP 169 169 169 ASP ASP B . n 
B 1 170 PRO 170 170 170 PRO PRO B . n 
B 1 171 ASP 171 171 171 ASP ASP B . n 
B 1 172 ALA 172 172 172 ALA ALA B . n 
B 1 173 LEU 173 173 173 LEU LEU B . n 
B 1 174 LEU 174 174 174 LEU LEU B . n 
B 1 175 PHE 175 175 175 PHE PHE B . n 
B 1 176 TYR 176 176 176 TYR TYR B . n 
B 1 177 ASN 177 177 177 ASN ASN B . n 
B 1 178 ASP 178 178 178 ASP ASP B . n 
B 1 179 TYR 179 179 179 TYR TYR B . n 
B 1 180 ASN 180 180 180 ASN ASN B . n 
B 1 181 GLU 181 181 181 GLU GLU B . n 
B 1 182 CYS 182 182 182 CYS CYS B . n 
B 1 183 PHE 183 183 183 PHE PHE B . n 
B 1 184 PRO 184 184 184 PRO PRO B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 LYS 186 186 186 LYS LYS B . n 
B 1 187 ARG 187 187 187 ARG ARG B . n 
B 1 188 GLU 188 188 188 GLU GLU B . n 
B 1 189 LYS 189 189 189 LYS LYS B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 PHE 191 191 191 PHE PHE B . n 
B 1 192 ALA 192 192 192 ALA ALA B . n 
B 1 193 LEU 193 193 193 LEU LEU B . n 
B 1 194 VAL 194 194 194 VAL VAL B . n 
B 1 195 LYS 195 195 195 LYS LYS B . n 
B 1 196 SER 196 196 196 SER SER B . n 
B 1 197 LEU 197 197 197 LEU LEU B . n 
B 1 198 ARG 198 198 198 ARG ARG B . n 
B 1 199 ASP 199 199 199 ASP ASP B . n 
B 1 200 LYS 200 200 200 LYS LYS B . n 
B 1 201 GLY 201 201 201 GLY GLY B . n 
B 1 202 ILE 202 202 202 ILE ILE B . n 
B 1 203 PRO 203 203 203 PRO PRO B . n 
B 1 204 ILE 204 204 204 ILE ILE B . n 
B 1 205 HIS 205 205 205 HIS HIS B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 ILE 207 207 207 ILE ILE B . n 
B 1 208 GLY 208 208 208 GLY GLY B . n 
B 1 209 MET 209 209 209 MET MET B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 HIS 212 212 212 HIS HIS B . n 
B 1 213 TRP 213 213 213 TRP TRP B . n 
B 1 214 SER 214 214 214 SER SER B . n 
B 1 215 LEU 215 215 215 LEU LEU B . n 
B 1 216 THR 216 216 216 THR THR B . n 
B 1 217 ARG 217 217 217 ARG ARG B . n 
B 1 218 PRO 218 218 218 PRO PRO B . n 
B 1 219 SER 219 219 219 SER SER B . n 
B 1 220 LEU 220 220 220 LEU LEU B . n 
B 1 221 ASP 221 221 221 ASP ASP B . n 
B 1 222 GLU 222 222 222 GLU GLU B . n 
B 1 223 ILE 223 223 223 ILE ILE B . n 
B 1 224 ARG 224 224 224 ARG ARG B . n 
B 1 225 ALA 225 225 225 ALA ALA B . n 
B 1 226 ALA 226 226 226 ALA ALA B . n 
B 1 227 ILE 227 227 227 ILE ILE B . n 
B 1 228 GLU 228 228 228 GLU GLU B . n 
B 1 229 ARG 229 229 229 ARG ARG B . n 
B 1 230 TYR 230 230 230 TYR TYR B . n 
B 1 231 ALA 231 231 231 ALA ALA B . n 
B 1 232 SER 232 232 232 SER SER B . n 
B 1 233 LEU 233 233 233 LEU LEU B . n 
B 1 234 GLY 234 234 234 GLY GLY B . n 
B 1 235 VAL 235 235 235 VAL VAL B . n 
B 1 236 VAL 236 236 236 VAL VAL B . n 
B 1 237 LEU 237 237 237 LEU LEU B . n 
B 1 238 HIS 238 238 238 HIS HIS B . n 
B 1 239 ILE 239 239 239 ILE ILE B . n 
B 1 240 THR 240 240 240 THR THR B . n 
B 1 241 GLY 241 241 241 GLY GLY B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 ASP 243 243 243 ASP ASP B . n 
B 1 244 VAL 244 244 244 VAL VAL B . n 
B 1 245 SER 245 245 245 SER SER B . n 
B 1 246 MET 246 246 246 MET MET B . n 
B 1 247 PHE 247 247 247 PHE PHE B . n 
B 1 248 GLU 248 248 248 GLU GLU B . n 
B 1 249 PHE 249 249 249 PHE PHE B . n 
B 1 250 HIS 250 250 250 HIS HIS B . n 
B 1 251 ASP 251 251 251 ASP ASP B . n 
B 1 252 ARG 252 252 252 ARG ARG B . n 
B 1 253 ARG 253 253 253 ARG ARG B . n 
B 1 254 THR 254 254 254 THR THR B . n 
B 1 255 ASP 255 255 255 ASP ASP B . n 
B 1 256 LEU 256 256 256 LEU LEU B . n 
B 1 257 ALA 257 257 257 ALA ALA B . n 
B 1 258 ALA 258 258 258 ALA ALA B . n 
B 1 259 PRO 259 259 259 PRO PRO B . n 
B 1 260 THR 260 260 260 THR THR B . n 
B 1 261 SER 261 261 261 SER SER B . n 
B 1 262 GLU 262 262 262 GLU GLU B . n 
B 1 263 MET 263 263 263 MET MET B . n 
B 1 264 ILE 264 264 264 ILE ILE B . n 
B 1 265 GLU 265 265 265 GLU GLU B . n 
B 1 266 ARG 266 266 266 ARG ARG B . n 
B 1 267 GLN 267 267 267 GLN GLN B . n 
B 1 268 ALA 268 268 268 ALA ALA B . n 
B 1 269 GLU 269 269 269 GLU GLU B . n 
B 1 270 ARG 270 270 270 ARG ARG B . n 
B 1 271 TYR 271 271 271 TYR TYR B . n 
B 1 272 GLY 272 272 272 GLY GLY B . n 
B 1 273 GLN 273 273 273 GLN GLN B . n 
B 1 274 ILE 274 274 274 ILE ILE B . n 
B 1 275 PHE 275 275 275 PHE PHE B . n 
B 1 276 ALA 276 276 276 ALA ALA B . n 
B 1 277 LEU 277 277 277 LEU LEU B . n 
B 1 278 PHE 278 278 278 PHE PHE B . n 
B 1 279 LYS 279 279 279 LYS LYS B . n 
B 1 280 GLU 280 280 280 GLU GLU B . n 
B 1 281 TYR 281 281 281 TYR TYR B . n 
B 1 282 ARG 282 282 282 ARG ARG B . n 
B 1 283 ASP 283 283 283 ASP ASP B . n 
B 1 284 VAL 284 284 284 VAL VAL B . n 
B 1 285 ILE 285 285 285 ILE ILE B . n 
B 1 286 GLN 286 286 286 GLN GLN B . n 
B 1 287 SER 287 287 287 SER SER B . n 
B 1 288 VAL 288 288 288 VAL VAL B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 PHE 290 290 290 PHE PHE B . n 
B 1 291 TRP 291 291 291 TRP TRP B . n 
B 1 292 GLY 292 292 292 GLY GLY B . n 
B 1 293 ILE 293 293 293 ILE ILE B . n 
B 1 294 ALA 294 294 294 ALA ALA B . n 
B 1 295 ASP 295 295 295 ASP ASP B . n 
B 1 296 ASP 296 296 296 ASP ASP B . n 
B 1 297 HIS 297 297 297 HIS HIS B . n 
B 1 298 THR 298 298 298 THR THR B . n 
B 1 299 TRP 299 299 299 TRP TRP B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 ASP 301 301 301 ASP ASP B . n 
B 1 302 ASN 302 302 302 ASN ASN B . n 
B 1 303 PHE 303 303 303 PHE PHE B . n 
B 1 304 PRO 304 304 304 PRO PRO B . n 
B 1 305 VAL 305 305 305 VAL VAL B . n 
B 1 306 HIS 306 306 306 HIS HIS B . n 
B 1 307 GLY 307 307 307 GLY GLY B . n 
B 1 308 ARG 308 308 308 ARG ARG B . n 
B 1 309 LYS 309 309 309 LYS LYS B . n 
B 1 310 ASN 310 310 310 ASN ASN B . n 
B 1 311 TRP 311 311 311 TRP TRP B . n 
B 1 312 PRO 312 312 312 PRO PRO B . n 
B 1 313 LEU 313 313 313 LEU LEU B . n 
B 1 314 LEU 314 314 314 LEU LEU B . n 
B 1 315 PHE 315 315 315 PHE PHE B . n 
B 1 316 ASP 316 316 316 ASP ASP B . n 
B 1 317 GLU 317 317 317 GLU GLU B . n 
B 1 318 GLN 318 318 318 GLN GLN B . n 
B 1 319 HIS 319 319 319 HIS HIS B . n 
B 1 320 LYS 320 320 320 LYS LYS B . n 
B 1 321 PRO 321 321 321 PRO PRO B . n 
B 1 322 LYS 322 322 322 LYS LYS B . n 
B 1 323 PRO 323 323 323 PRO PRO B . n 
B 1 324 ALA 324 324 324 ALA ALA B . n 
B 1 325 PHE 325 325 325 PHE PHE B . n 
B 1 326 TRP 326 326 326 TRP TRP B . n 
B 1 327 ARG 327 327 327 ARG ARG B . n 
B 1 328 ALA 328 328 328 ALA ALA B . n 
B 1 329 VAL 329 329 329 VAL VAL B . n 
B 1 330 SER 330 330 330 SER SER B . n 
B 1 331 VAL 331 331 331 VAL VAL B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 HOH 1   401 350 HOH HOH A . 
C 2 HOH 2   402 177 HOH HOH A . 
C 2 HOH 3   403 339 HOH HOH A . 
C 2 HOH 4   404 331 HOH HOH A . 
C 2 HOH 5   405 226 HOH HOH A . 
C 2 HOH 6   406 164 HOH HOH A . 
C 2 HOH 7   407 344 HOH HOH A . 
C 2 HOH 8   408 365 HOH HOH A . 
C 2 HOH 9   409 157 HOH HOH A . 
C 2 HOH 10  410 13  HOH HOH A . 
C 2 HOH 11  411 306 HOH HOH A . 
C 2 HOH 12  412 298 HOH HOH A . 
C 2 HOH 13  413 329 HOH HOH A . 
C 2 HOH 14  414 430 HOH HOH A . 
C 2 HOH 15  415 156 HOH HOH A . 
C 2 HOH 16  416 141 HOH HOH A . 
C 2 HOH 17  417 171 HOH HOH A . 
C 2 HOH 18  418 52  HOH HOH A . 
C 2 HOH 19  419 265 HOH HOH A . 
C 2 HOH 20  420 33  HOH HOH A . 
C 2 HOH 21  421 11  HOH HOH A . 
C 2 HOH 22  422 1   HOH HOH A . 
C 2 HOH 23  423 375 HOH HOH A . 
C 2 HOH 24  424 31  HOH HOH A . 
C 2 HOH 25  425 6   HOH HOH A . 
C 2 HOH 26  426 104 HOH HOH A . 
C 2 HOH 27  427 103 HOH HOH A . 
C 2 HOH 28  428 163 HOH HOH A . 
C 2 HOH 29  429 172 HOH HOH A . 
C 2 HOH 30  430 129 HOH HOH A . 
C 2 HOH 31  431 296 HOH HOH A . 
C 2 HOH 32  432 50  HOH HOH A . 
C 2 HOH 33  433 42  HOH HOH A . 
C 2 HOH 34  434 97  HOH HOH A . 
C 2 HOH 35  435 179 HOH HOH A . 
C 2 HOH 36  436 85  HOH HOH A . 
C 2 HOH 37  437 14  HOH HOH A . 
C 2 HOH 38  438 8   HOH HOH A . 
C 2 HOH 39  439 117 HOH HOH A . 
C 2 HOH 40  440 385 HOH HOH A . 
C 2 HOH 41  441 77  HOH HOH A . 
C 2 HOH 42  442 119 HOH HOH A . 
C 2 HOH 43  443 102 HOH HOH A . 
C 2 HOH 44  444 4   HOH HOH A . 
C 2 HOH 45  445 233 HOH HOH A . 
C 2 HOH 46  446 46  HOH HOH A . 
C 2 HOH 47  447 105 HOH HOH A . 
C 2 HOH 48  448 499 HOH HOH A . 
C 2 HOH 49  449 86  HOH HOH A . 
C 2 HOH 50  450 27  HOH HOH A . 
C 2 HOH 51  451 100 HOH HOH A . 
C 2 HOH 52  452 45  HOH HOH A . 
C 2 HOH 53  453 70  HOH HOH A . 
C 2 HOH 54  454 272 HOH HOH A . 
C 2 HOH 55  455 58  HOH HOH A . 
C 2 HOH 56  456 47  HOH HOH A . 
C 2 HOH 57  457 43  HOH HOH A . 
C 2 HOH 58  458 39  HOH HOH A . 
C 2 HOH 59  459 7   HOH HOH A . 
C 2 HOH 60  460 80  HOH HOH A . 
C 2 HOH 61  461 523 HOH HOH A . 
C 2 HOH 62  462 311 HOH HOH A . 
C 2 HOH 63  463 38  HOH HOH A . 
C 2 HOH 64  464 383 HOH HOH A . 
C 2 HOH 65  465 194 HOH HOH A . 
C 2 HOH 66  466 227 HOH HOH A . 
C 2 HOH 67  467 41  HOH HOH A . 
C 2 HOH 68  468 301 HOH HOH A . 
C 2 HOH 69  469 51  HOH HOH A . 
C 2 HOH 70  470 239 HOH HOH A . 
C 2 HOH 71  471 29  HOH HOH A . 
C 2 HOH 72  472 185 HOH HOH A . 
C 2 HOH 73  473 488 HOH HOH A . 
C 2 HOH 74  474 270 HOH HOH A . 
C 2 HOH 75  475 17  HOH HOH A . 
C 2 HOH 76  476 342 HOH HOH A . 
C 2 HOH 77  477 295 HOH HOH A . 
C 2 HOH 78  478 61  HOH HOH A . 
C 2 HOH 79  479 322 HOH HOH A . 
C 2 HOH 80  480 48  HOH HOH A . 
C 2 HOH 81  481 243 HOH HOH A . 
C 2 HOH 82  482 15  HOH HOH A . 
C 2 HOH 83  483 94  HOH HOH A . 
C 2 HOH 84  484 274 HOH HOH A . 
C 2 HOH 85  485 332 HOH HOH A . 
C 2 HOH 86  486 245 HOH HOH A . 
C 2 HOH 87  487 190 HOH HOH A . 
C 2 HOH 88  488 66  HOH HOH A . 
C 2 HOH 89  489 324 HOH HOH A . 
C 2 HOH 90  490 371 HOH HOH A . 
C 2 HOH 91  491 150 HOH HOH A . 
C 2 HOH 92  492 276 HOH HOH A . 
C 2 HOH 93  493 389 HOH HOH A . 
C 2 HOH 94  494 345 HOH HOH A . 
C 2 HOH 95  495 168 HOH HOH A . 
C 2 HOH 96  496 162 HOH HOH A . 
C 2 HOH 97  497 453 HOH HOH A . 
C 2 HOH 98  498 55  HOH HOH A . 
C 2 HOH 99  499 16  HOH HOH A . 
C 2 HOH 100 500 469 HOH HOH A . 
C 2 HOH 101 501 300 HOH HOH A . 
C 2 HOH 102 502 12  HOH HOH A . 
C 2 HOH 103 503 250 HOH HOH A . 
C 2 HOH 104 504 123 HOH HOH A . 
C 2 HOH 105 505 347 HOH HOH A . 
C 2 HOH 106 506 136 HOH HOH A . 
C 2 HOH 107 507 455 HOH HOH A . 
C 2 HOH 108 508 432 HOH HOH A . 
C 2 HOH 109 509 37  HOH HOH A . 
C 2 HOH 110 510 40  HOH HOH A . 
C 2 HOH 111 511 213 HOH HOH A . 
C 2 HOH 112 512 465 HOH HOH A . 
C 2 HOH 113 513 88  HOH HOH A . 
C 2 HOH 114 514 473 HOH HOH A . 
C 2 HOH 115 515 492 HOH HOH A . 
C 2 HOH 116 516 65  HOH HOH A . 
C 2 HOH 117 517 87  HOH HOH A . 
C 2 HOH 118 518 251 HOH HOH A . 
C 2 HOH 119 519 143 HOH HOH A . 
C 2 HOH 120 520 349 HOH HOH A . 
C 2 HOH 121 521 353 HOH HOH A . 
C 2 HOH 122 522 283 HOH HOH A . 
C 2 HOH 123 523 92  HOH HOH A . 
C 2 HOH 124 524 309 HOH HOH A . 
C 2 HOH 125 525 35  HOH HOH A . 
C 2 HOH 126 526 408 HOH HOH A . 
C 2 HOH 127 527 275 HOH HOH A . 
C 2 HOH 128 528 112 HOH HOH A . 
C 2 HOH 129 529 130 HOH HOH A . 
C 2 HOH 130 530 25  HOH HOH A . 
C 2 HOH 131 531 62  HOH HOH A . 
C 2 HOH 132 532 218 HOH HOH A . 
C 2 HOH 133 533 153 HOH HOH A . 
C 2 HOH 134 534 89  HOH HOH A . 
C 2 HOH 135 535 491 HOH HOH A . 
C 2 HOH 136 536 369 HOH HOH A . 
C 2 HOH 137 537 254 HOH HOH A . 
C 2 HOH 138 538 74  HOH HOH A . 
C 2 HOH 139 539 139 HOH HOH A . 
C 2 HOH 140 540 220 HOH HOH A . 
C 2 HOH 141 541 203 HOH HOH A . 
C 2 HOH 142 542 278 HOH HOH A . 
C 2 HOH 143 543 357 HOH HOH A . 
C 2 HOH 144 544 67  HOH HOH A . 
C 2 HOH 145 545 170 HOH HOH A . 
C 2 HOH 146 546 297 HOH HOH A . 
C 2 HOH 147 547 428 HOH HOH A . 
C 2 HOH 148 548 484 HOH HOH A . 
C 2 HOH 149 549 192 HOH HOH A . 
C 2 HOH 150 550 352 HOH HOH A . 
C 2 HOH 151 551 216 HOH HOH A . 
C 2 HOH 152 552 391 HOH HOH A . 
C 2 HOH 153 553 246 HOH HOH A . 
C 2 HOH 154 554 466 HOH HOH A . 
C 2 HOH 155 555 148 HOH HOH A . 
C 2 HOH 156 556 82  HOH HOH A . 
C 2 HOH 157 557 461 HOH HOH A . 
C 2 HOH 158 558 262 HOH HOH A . 
C 2 HOH 159 559 147 HOH HOH A . 
C 2 HOH 160 560 284 HOH HOH A . 
C 2 HOH 161 561 236 HOH HOH A . 
C 2 HOH 162 562 135 HOH HOH A . 
C 2 HOH 163 563 124 HOH HOH A . 
C 2 HOH 164 564 209 HOH HOH A . 
C 2 HOH 165 565 263 HOH HOH A . 
C 2 HOH 166 566 53  HOH HOH A . 
C 2 HOH 167 567 181 HOH HOH A . 
C 2 HOH 168 568 167 HOH HOH A . 
C 2 HOH 169 569 126 HOH HOH A . 
C 2 HOH 170 570 425 HOH HOH A . 
C 2 HOH 171 571 71  HOH HOH A . 
C 2 HOH 172 572 279 HOH HOH A . 
C 2 HOH 173 573 395 HOH HOH A . 
C 2 HOH 174 574 328 HOH HOH A . 
C 2 HOH 175 575 486 HOH HOH A . 
C 2 HOH 176 576 531 HOH HOH A . 
C 2 HOH 177 577 144 HOH HOH A . 
C 2 HOH 178 578 22  HOH HOH A . 
C 2 HOH 179 579 359 HOH HOH A . 
C 2 HOH 180 580 116 HOH HOH A . 
C 2 HOH 181 581 202 HOH HOH A . 
C 2 HOH 182 582 193 HOH HOH A . 
C 2 HOH 183 583 374 HOH HOH A . 
C 2 HOH 184 584 364 HOH HOH A . 
C 2 HOH 185 585 415 HOH HOH A . 
C 2 HOH 186 586 285 HOH HOH A . 
C 2 HOH 187 587 540 HOH HOH A . 
C 2 HOH 188 588 426 HOH HOH A . 
C 2 HOH 189 589 522 HOH HOH A . 
C 2 HOH 190 590 372 HOH HOH A . 
C 2 HOH 191 591 211 HOH HOH A . 
C 2 HOH 192 592 290 HOH HOH A . 
C 2 HOH 193 593 358 HOH HOH A . 
C 2 HOH 194 594 341 HOH HOH A . 
C 2 HOH 195 595 303 HOH HOH A . 
C 2 HOH 196 596 412 HOH HOH A . 
C 2 HOH 197 597 248 HOH HOH A . 
C 2 HOH 198 598 467 HOH HOH A . 
C 2 HOH 199 599 258 HOH HOH A . 
C 2 HOH 200 600 475 HOH HOH A . 
C 2 HOH 201 601 509 HOH HOH A . 
C 2 HOH 202 602 244 HOH HOH A . 
C 2 HOH 203 603 356 HOH HOH A . 
C 2 HOH 204 604 261 HOH HOH A . 
C 2 HOH 205 605 362 HOH HOH A . 
C 2 HOH 206 606 376 HOH HOH A . 
C 2 HOH 207 607 241 HOH HOH A . 
C 2 HOH 208 608 49  HOH HOH A . 
C 2 HOH 209 609 380 HOH HOH A . 
C 2 HOH 210 610 533 HOH HOH A . 
C 2 HOH 211 611 416 HOH HOH A . 
C 2 HOH 212 612 511 HOH HOH A . 
C 2 HOH 213 613 310 HOH HOH A . 
C 2 HOH 214 614 519 HOH HOH A . 
C 2 HOH 215 615 538 HOH HOH A . 
C 2 HOH 216 616 340 HOH HOH A . 
C 2 HOH 217 617 541 HOH HOH A . 
C 2 HOH 218 618 118 HOH HOH A . 
C 2 HOH 219 619 496 HOH HOH A . 
C 2 HOH 220 620 427 HOH HOH A . 
C 2 HOH 221 621 460 HOH HOH A . 
C 2 HOH 222 622 260 HOH HOH A . 
C 2 HOH 223 623 388 HOH HOH A . 
C 2 HOH 224 624 480 HOH HOH A . 
C 2 HOH 225 625 481 HOH HOH A . 
C 2 HOH 226 626 487 HOH HOH A . 
C 2 HOH 227 627 452 HOH HOH A . 
C 2 HOH 228 628 485 HOH HOH A . 
C 2 HOH 229 629 346 HOH HOH A . 
C 2 HOH 230 630 422 HOH HOH A . 
C 2 HOH 231 631 180 HOH HOH A . 
C 2 HOH 232 632 527 HOH HOH A . 
C 2 HOH 233 633 409 HOH HOH A . 
C 2 HOH 234 634 304 HOH HOH A . 
C 2 HOH 235 635 410 HOH HOH A . 
C 2 HOH 236 636 520 HOH HOH A . 
C 2 HOH 237 637 429 HOH HOH A . 
C 2 HOH 238 638 404 HOH HOH A . 
C 2 HOH 239 639 506 HOH HOH A . 
C 2 HOH 240 640 351 HOH HOH A . 
C 2 HOH 241 641 318 HOH HOH A . 
C 2 HOH 242 642 490 HOH HOH A . 
C 2 HOH 243 643 503 HOH HOH A . 
C 2 HOH 244 644 439 HOH HOH A . 
C 2 HOH 245 645 434 HOH HOH A . 
C 2 HOH 246 646 472 HOH HOH A . 
C 2 HOH 247 647 451 HOH HOH A . 
C 2 HOH 248 648 508 HOH HOH A . 
C 2 HOH 249 649 392 HOH HOH A . 
C 2 HOH 250 650 107 HOH HOH A . 
C 2 HOH 251 651 450 HOH HOH A . 
C 2 HOH 252 652 539 HOH HOH A . 
C 2 HOH 253 653 401 HOH HOH A . 
C 2 HOH 254 654 532 HOH HOH A . 
C 2 HOH 255 655 214 HOH HOH A . 
C 2 HOH 256 656 286 HOH HOH A . 
C 2 HOH 257 657 474 HOH HOH A . 
C 2 HOH 258 658 259 HOH HOH A . 
C 2 HOH 259 659 59  HOH HOH A . 
C 2 HOH 260 660 242 HOH HOH A . 
C 2 HOH 261 661 191 HOH HOH A . 
C 2 HOH 262 662 536 HOH HOH A . 
C 2 HOH 263 663 84  HOH HOH A . 
C 2 HOH 264 664 355 HOH HOH A . 
C 2 HOH 265 665 530 HOH HOH A . 
C 2 HOH 266 666 462 HOH HOH A . 
C 2 HOH 267 667 456 HOH HOH A . 
C 2 HOH 268 668 448 HOH HOH A . 
C 2 HOH 269 669 113 HOH HOH A . 
C 2 HOH 270 670 535 HOH HOH A . 
C 2 HOH 271 671 210 HOH HOH A . 
C 2 HOH 272 672 217 HOH HOH A . 
C 2 HOH 273 673 370 HOH HOH A . 
C 2 HOH 274 674 128 HOH HOH A . 
C 2 HOH 275 675 471 HOH HOH A . 
C 2 HOH 276 676 534 HOH HOH A . 
C 2 HOH 277 677 343 HOH HOH A . 
C 2 HOH 278 678 438 HOH HOH A . 
C 2 HOH 279 679 366 HOH HOH A . 
C 2 HOH 280 680 223 HOH HOH A . 
C 2 HOH 281 681 419 HOH HOH A . 
C 2 HOH 282 682 440 HOH HOH A . 
C 2 HOH 283 683 377 HOH HOH A . 
C 2 HOH 284 684 458 HOH HOH A . 
C 2 HOH 285 685 381 HOH HOH A . 
C 2 HOH 286 686 204 HOH HOH A . 
C 2 HOH 287 687 512 HOH HOH A . 
C 2 HOH 288 688 338 HOH HOH A . 
C 2 HOH 289 689 293 HOH HOH A . 
C 2 HOH 290 690 421 HOH HOH A . 
C 2 HOH 291 691 515 HOH HOH A . 
C 2 HOH 292 692 483 HOH HOH A . 
C 2 HOH 293 693 537 HOH HOH A . 
D 2 HOH 1   401 414 HOH HOH B . 
D 2 HOH 2   402 125 HOH HOH B . 
D 2 HOH 3   403 9   HOH HOH B . 
D 2 HOH 4   404 256 HOH HOH B . 
D 2 HOH 5   405 81  HOH HOH B . 
D 2 HOH 6   406 134 HOH HOH B . 
D 2 HOH 7   407 63  HOH HOH B . 
D 2 HOH 8   408 197 HOH HOH B . 
D 2 HOH 9   409 529 HOH HOH B . 
D 2 HOH 10  410 294 HOH HOH B . 
D 2 HOH 11  411 69  HOH HOH B . 
D 2 HOH 12  412 228 HOH HOH B . 
D 2 HOH 13  413 106 HOH HOH B . 
D 2 HOH 14  414 196 HOH HOH B . 
D 2 HOH 15  415 444 HOH HOH B . 
D 2 HOH 16  416 302 HOH HOH B . 
D 2 HOH 17  417 18  HOH HOH B . 
D 2 HOH 18  418 21  HOH HOH B . 
D 2 HOH 19  419 160 HOH HOH B . 
D 2 HOH 20  420 20  HOH HOH B . 
D 2 HOH 21  421 36  HOH HOH B . 
D 2 HOH 22  422 98  HOH HOH B . 
D 2 HOH 23  423 3   HOH HOH B . 
D 2 HOH 24  424 5   HOH HOH B . 
D 2 HOH 25  425 120 HOH HOH B . 
D 2 HOH 26  426 200 HOH HOH B . 
D 2 HOH 27  427 224 HOH HOH B . 
D 2 HOH 28  428 257 HOH HOH B . 
D 2 HOH 29  429 79  HOH HOH B . 
D 2 HOH 30  430 273 HOH HOH B . 
D 2 HOH 31  431 24  HOH HOH B . 
D 2 HOH 32  432 384 HOH HOH B . 
D 2 HOH 33  433 91  HOH HOH B . 
D 2 HOH 34  434 184 HOH HOH B . 
D 2 HOH 35  435 111 HOH HOH B . 
D 2 HOH 36  436 348 HOH HOH B . 
D 2 HOH 37  437 169 HOH HOH B . 
D 2 HOH 38  438 34  HOH HOH B . 
D 2 HOH 39  439 513 HOH HOH B . 
D 2 HOH 40  440 234 HOH HOH B . 
D 2 HOH 41  441 271 HOH HOH B . 
D 2 HOH 42  442 281 HOH HOH B . 
D 2 HOH 43  443 109 HOH HOH B . 
D 2 HOH 44  444 336 HOH HOH B . 
D 2 HOH 45  445 238 HOH HOH B . 
D 2 HOH 46  446 54  HOH HOH B . 
D 2 HOH 47  447 2   HOH HOH B . 
D 2 HOH 48  448 122 HOH HOH B . 
D 2 HOH 49  449 110 HOH HOH B . 
D 2 HOH 50  450 320 HOH HOH B . 
D 2 HOH 51  451 188 HOH HOH B . 
D 2 HOH 52  452 219 HOH HOH B . 
D 2 HOH 53  453 155 HOH HOH B . 
D 2 HOH 54  454 83  HOH HOH B . 
D 2 HOH 55  455 308 HOH HOH B . 
D 2 HOH 56  456 152 HOH HOH B . 
D 2 HOH 57  457 206 HOH HOH B . 
D 2 HOH 58  458 442 HOH HOH B . 
D 2 HOH 59  459 449 HOH HOH B . 
D 2 HOH 60  460 131 HOH HOH B . 
D 2 HOH 61  461 159 HOH HOH B . 
D 2 HOH 62  462 267 HOH HOH B . 
D 2 HOH 63  463 99  HOH HOH B . 
D 2 HOH 64  464 495 HOH HOH B . 
D 2 HOH 65  465 138 HOH HOH B . 
D 2 HOH 66  466 28  HOH HOH B . 
D 2 HOH 67  467 64  HOH HOH B . 
D 2 HOH 68  468 72  HOH HOH B . 
D 2 HOH 69  469 287 HOH HOH B . 
D 2 HOH 70  470 237 HOH HOH B . 
D 2 HOH 71  471 95  HOH HOH B . 
D 2 HOH 72  472 403 HOH HOH B . 
D 2 HOH 73  473 282 HOH HOH B . 
D 2 HOH 74  474 158 HOH HOH B . 
D 2 HOH 75  475 149 HOH HOH B . 
D 2 HOH 76  476 60  HOH HOH B . 
D 2 HOH 77  477 26  HOH HOH B . 
D 2 HOH 78  478 44  HOH HOH B . 
D 2 HOH 79  479 114 HOH HOH B . 
D 2 HOH 80  480 90  HOH HOH B . 
D 2 HOH 81  481 277 HOH HOH B . 
D 2 HOH 82  482 330 HOH HOH B . 
D 2 HOH 83  483 182 HOH HOH B . 
D 2 HOH 84  484 108 HOH HOH B . 
D 2 HOH 85  485 145 HOH HOH B . 
D 2 HOH 86  486 115 HOH HOH B . 
D 2 HOH 87  487 327 HOH HOH B . 
D 2 HOH 88  488 161 HOH HOH B . 
D 2 HOH 89  489 78  HOH HOH B . 
D 2 HOH 90  490 127 HOH HOH B . 
D 2 HOH 91  491 23  HOH HOH B . 
D 2 HOH 92  492 183 HOH HOH B . 
D 2 HOH 93  493 19  HOH HOH B . 
D 2 HOH 94  494 132 HOH HOH B . 
D 2 HOH 95  495 494 HOH HOH B . 
D 2 HOH 96  496 253 HOH HOH B . 
D 2 HOH 97  497 255 HOH HOH B . 
D 2 HOH 98  498 225 HOH HOH B . 
D 2 HOH 99  499 398 HOH HOH B . 
D 2 HOH 100 500 68  HOH HOH B . 
D 2 HOH 101 501 140 HOH HOH B . 
D 2 HOH 102 502 166 HOH HOH B . 
D 2 HOH 103 503 32  HOH HOH B . 
D 2 HOH 104 504 418 HOH HOH B . 
D 2 HOH 105 505 205 HOH HOH B . 
D 2 HOH 106 506 321 HOH HOH B . 
D 2 HOH 107 507 56  HOH HOH B . 
D 2 HOH 108 508 363 HOH HOH B . 
D 2 HOH 109 509 75  HOH HOH B . 
D 2 HOH 110 510 231 HOH HOH B . 
D 2 HOH 111 511 393 HOH HOH B . 
D 2 HOH 112 512 178 HOH HOH B . 
D 2 HOH 113 513 379 HOH HOH B . 
D 2 HOH 114 514 101 HOH HOH B . 
D 2 HOH 115 515 73  HOH HOH B . 
D 2 HOH 116 516 397 HOH HOH B . 
D 2 HOH 117 517 146 HOH HOH B . 
D 2 HOH 118 518 288 HOH HOH B . 
D 2 HOH 119 519 335 HOH HOH B . 
D 2 HOH 120 520 314 HOH HOH B . 
D 2 HOH 121 521 201 HOH HOH B . 
D 2 HOH 122 522 30  HOH HOH B . 
D 2 HOH 123 523 249 HOH HOH B . 
D 2 HOH 124 524 307 HOH HOH B . 
D 2 HOH 125 525 326 HOH HOH B . 
D 2 HOH 126 526 360 HOH HOH B . 
D 2 HOH 127 527 317 HOH HOH B . 
D 2 HOH 128 528 264 HOH HOH B . 
D 2 HOH 129 529 378 HOH HOH B . 
D 2 HOH 130 530 96  HOH HOH B . 
D 2 HOH 131 531 137 HOH HOH B . 
D 2 HOH 132 532 289 HOH HOH B . 
D 2 HOH 133 533 187 HOH HOH B . 
D 2 HOH 134 534 186 HOH HOH B . 
D 2 HOH 135 535 525 HOH HOH B . 
D 2 HOH 136 536 457 HOH HOH B . 
D 2 HOH 137 537 199 HOH HOH B . 
D 2 HOH 138 538 323 HOH HOH B . 
D 2 HOH 139 539 420 HOH HOH B . 
D 2 HOH 140 540 354 HOH HOH B . 
D 2 HOH 141 541 417 HOH HOH B . 
D 2 HOH 142 542 151 HOH HOH B . 
D 2 HOH 143 543 268 HOH HOH B . 
D 2 HOH 144 544 291 HOH HOH B . 
D 2 HOH 145 545 215 HOH HOH B . 
D 2 HOH 146 546 333 HOH HOH B . 
D 2 HOH 147 547 240 HOH HOH B . 
D 2 HOH 148 548 247 HOH HOH B . 
D 2 HOH 149 549 463 HOH HOH B . 
D 2 HOH 150 550 292 HOH HOH B . 
D 2 HOH 151 551 252 HOH HOH B . 
D 2 HOH 152 552 142 HOH HOH B . 
D 2 HOH 153 553 489 HOH HOH B . 
D 2 HOH 154 554 406 HOH HOH B . 
D 2 HOH 155 555 173 HOH HOH B . 
D 2 HOH 156 556 207 HOH HOH B . 
D 2 HOH 157 557 280 HOH HOH B . 
D 2 HOH 158 558 382 HOH HOH B . 
D 2 HOH 159 559 76  HOH HOH B . 
D 2 HOH 160 560 313 HOH HOH B . 
D 2 HOH 161 561 498 HOH HOH B . 
D 2 HOH 162 562 154 HOH HOH B . 
D 2 HOH 163 563 542 HOH HOH B . 
D 2 HOH 164 564 221 HOH HOH B . 
D 2 HOH 165 565 470 HOH HOH B . 
D 2 HOH 166 566 387 HOH HOH B . 
D 2 HOH 167 567 121 HOH HOH B . 
D 2 HOH 168 568 235 HOH HOH B . 
D 2 HOH 169 569 477 HOH HOH B . 
D 2 HOH 170 570 230 HOH HOH B . 
D 2 HOH 171 571 464 HOH HOH B . 
D 2 HOH 172 572 57  HOH HOH B . 
D 2 HOH 173 573 189 HOH HOH B . 
D 2 HOH 174 574 315 HOH HOH B . 
D 2 HOH 175 575 368 HOH HOH B . 
D 2 HOH 176 576 479 HOH HOH B . 
D 2 HOH 177 577 93  HOH HOH B . 
D 2 HOH 178 578 305 HOH HOH B . 
D 2 HOH 179 579 502 HOH HOH B . 
D 2 HOH 180 580 445 HOH HOH B . 
D 2 HOH 181 581 222 HOH HOH B . 
D 2 HOH 182 582 174 HOH HOH B . 
D 2 HOH 183 583 423 HOH HOH B . 
D 2 HOH 184 584 454 HOH HOH B . 
D 2 HOH 185 585 390 HOH HOH B . 
D 2 HOH 186 586 396 HOH HOH B . 
D 2 HOH 187 587 402 HOH HOH B . 
D 2 HOH 188 588 175 HOH HOH B . 
D 2 HOH 189 589 165 HOH HOH B . 
D 2 HOH 190 590 399 HOH HOH B . 
D 2 HOH 191 591 337 HOH HOH B . 
D 2 HOH 192 592 334 HOH HOH B . 
D 2 HOH 193 593 504 HOH HOH B . 
D 2 HOH 194 594 500 HOH HOH B . 
D 2 HOH 195 595 521 HOH HOH B . 
D 2 HOH 196 596 299 HOH HOH B . 
D 2 HOH 197 597 386 HOH HOH B . 
D 2 HOH 198 598 510 HOH HOH B . 
D 2 HOH 199 599 516 HOH HOH B . 
D 2 HOH 200 600 524 HOH HOH B . 
D 2 HOH 201 601 411 HOH HOH B . 
D 2 HOH 202 602 208 HOH HOH B . 
D 2 HOH 203 603 528 HOH HOH B . 
D 2 HOH 204 604 517 HOH HOH B . 
D 2 HOH 205 605 507 HOH HOH B . 
D 2 HOH 206 606 195 HOH HOH B . 
D 2 HOH 207 607 373 HOH HOH B . 
D 2 HOH 208 608 361 HOH HOH B . 
D 2 HOH 209 609 316 HOH HOH B . 
D 2 HOH 210 610 407 HOH HOH B . 
D 2 HOH 211 611 212 HOH HOH B . 
D 2 HOH 212 612 413 HOH HOH B . 
D 2 HOH 213 613 312 HOH HOH B . 
D 2 HOH 214 614 441 HOH HOH B . 
D 2 HOH 215 615 526 HOH HOH B . 
D 2 HOH 216 616 468 HOH HOH B . 
D 2 HOH 217 617 505 HOH HOH B . 
D 2 HOH 218 618 229 HOH HOH B . 
D 2 HOH 219 619 400 HOH HOH B . 
D 2 HOH 220 620 446 HOH HOH B . 
D 2 HOH 221 621 394 HOH HOH B . 
D 2 HOH 222 622 431 HOH HOH B . 
D 2 HOH 223 623 443 HOH HOH B . 
D 2 HOH 224 624 478 HOH HOH B . 
D 2 HOH 225 625 269 HOH HOH B . 
D 2 HOH 226 626 367 HOH HOH B . 
D 2 HOH 227 627 518 HOH HOH B . 
D 2 HOH 228 628 459 HOH HOH B . 
D 2 HOH 229 629 501 HOH HOH B . 
D 2 HOH 230 630 198 HOH HOH B . 
D 2 HOH 231 631 476 HOH HOH B . 
D 2 HOH 232 632 497 HOH HOH B . 
D 2 HOH 233 633 493 HOH HOH B . 
D 2 HOH 234 634 424 HOH HOH B . 
D 2 HOH 235 635 176 HOH HOH B . 
D 2 HOH 236 636 405 HOH HOH B . 
D 2 HOH 237 637 435 HOH HOH B . 
D 2 HOH 238 638 433 HOH HOH B . 
D 2 HOH 239 639 447 HOH HOH B . 
D 2 HOH 240 640 482 HOH HOH B . 
D 2 HOH 241 641 437 HOH HOH B . 
D 2 HOH 242 642 319 HOH HOH B . 
D 2 HOH 243 643 232 HOH HOH B . 
D 2 HOH 244 644 133 HOH HOH B . 
D 2 HOH 245 645 266 HOH HOH B . 
D 2 HOH 246 646 436 HOH HOH B . 
D 2 HOH 247 647 325 HOH HOH B . 
D 2 HOH 248 648 514 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 0 B LYS 309 ? N  B B LYS 309 N  
2 1 Y 0 B LYS 309 ? CA B B LYS 309 CA 
3 1 Y 0 B LYS 309 ? C  B B LYS 309 C  
4 1 Y 0 B LYS 309 ? O  B B LYS 309 O  
5 1 Y 0 B LYS 309 ? CB B B LYS 309 CB 
6 1 Y 0 B LYS 309 ? CG B B LYS 309 CG 
7 1 Y 0 B LYS 309 ? CD B B LYS 309 CD 
8 1 Y 0 B LYS 309 ? CE B B LYS 309 CE 
9 1 Y 0 B LYS 309 ? NZ B B LYS 309 NZ 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   91.883 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FKH 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     169.317 
_cell.length_a_esd                 ? 
_cell.length_b                     80.218 
_cell.length_b_esd                 ? 
_cell.length_c                     78.961 
_cell.length_c_esd                 ? 
_cell.volume                       1071884.848 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FKH 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FKH 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          64.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2M Sodium acetate and 0.1M Sodium cacodylate buffer at pH 6.5.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 200K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          30.63 
_reflns.entry_id                                       9FKH 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               40.11 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     46869 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.07 
_reflns.pdbx_Rpim_I_all                                0.04 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.30 
_reflns_shell.d_res_low                                     2.38 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.6 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4495 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.63 
_reflns_shell.pdbx_Rpim_I_all                               0.40 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.66 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.47 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.66 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FKH 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             40.11 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     46848 
_refine.ls_number_reflns_R_free                  2258 
_refine.ls_number_reflns_R_work                  44590 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.48 
_refine.ls_percent_reflns_R_free                 4.82 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1724 
_refine.ls_R_factor_R_free                       0.2082 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1706 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.5636 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2507 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        40.11 
_refine_hist.number_atoms_solvent             541 
_refine_hist.number_atoms_total               5953 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5412 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0078 ? 5624 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8983 ? 7630 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0550 ? 793  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0057 ? 1000 ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.1026 ? 735  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.30 2.35  . . 156 2703 98.11 . . . . 0.2521 . . . . . . . . . . . 0.3001 
'X-RAY DIFFRACTION' 2.35 2.40  . . 138 2747 98.50 . . . . 0.2517 . . . . . . . . . . . 0.2898 
'X-RAY DIFFRACTION' 2.40 2.46  . . 124 2753 98.90 . . . . 0.2447 . . . . . . . . . . . 0.2712 
'X-RAY DIFFRACTION' 2.46 2.53  . . 130 2794 99.52 . . . . 0.2301 . . . . . . . . . . . 0.3016 
'X-RAY DIFFRACTION' 2.53 2.61  . . 109 2795 99.66 . . . . 0.2318 . . . . . . . . . . . 0.3058 
'X-RAY DIFFRACTION' 2.61 2.69  . . 140 2772 99.69 . . . . 0.2212 . . . . . . . . . . . 0.2613 
'X-RAY DIFFRACTION' 2.69 2.79  . . 142 2772 99.59 . . . . 0.2053 . . . . . . . . . . . 0.2588 
'X-RAY DIFFRACTION' 2.79 2.90  . . 150 2773 99.59 . . . . 0.2019 . . . . . . . . . . . 0.2474 
'X-RAY DIFFRACTION' 2.90 3.03  . . 138 2827 99.76 . . . . 0.1990 . . . . . . . . . . . 0.2825 
'X-RAY DIFFRACTION' 3.03 3.19  . . 133 2785 99.76 . . . . 0.1885 . . . . . . . . . . . 0.2154 
'X-RAY DIFFRACTION' 3.19 3.39  . . 165 2751 99.79 . . . . 0.1671 . . . . . . . . . . . 0.1993 
'X-RAY DIFFRACTION' 3.39 3.65  . . 147 2810 99.76 . . . . 0.1458 . . . . . . . . . . . 0.1765 
'X-RAY DIFFRACTION' 3.65 4.02  . . 134 2822 99.80 . . . . 0.1253 . . . . . . . . . . . 0.1652 
'X-RAY DIFFRACTION' 4.02 4.60  . . 152 2781 99.90 . . . . 0.1210 . . . . . . . . . . . 0.1586 
'X-RAY DIFFRACTION' 4.60 5.79  . . 168 2802 99.90 . . . . 0.1345 . . . . . . . . . . . 0.1705 
'X-RAY DIFFRACTION' 5.79 40.11 . . 132 2903 99.48 . . . . 0.1570 . . . . . . . . . . . 0.1703 
# 
_struct.entry_id                     9FKH 
_struct.title                        
'The structure of glycosynthase IXT6 (E241G mutant), the intracellular xylanase of G.proteiniphilus T-6' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FKH 
_struct_keywords.text            'IXT6, glycosynthase, hydrolase, Geobacillus proteiniphilus T-6, Geobacillus stearothermophilus' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q09LY9_GEOSE 
_struct_ref.pdbx_db_accession          Q09LY9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MNSSLPSLRDVFANDFRIGAAVNPVTIEMQKQLLIDHVNSITAENHMKFEHLQPEEGKFTFQEADRIVDFACSHRMAVRG
HTLVWHNQTPDWVFQDGQGHFVSRDVLLERMKCHISTVVRRYKGKIYCWDVINEAVADEGNELLRPSKWRQIIGDDFMEQ
AFLYAYEADPDALLFYNDYNECFPEKREKIFALVKSLRDKGIPIHGIGMQAHWSLTRPSLDEIRAAIERYASLGVVLHIT
ELDVSMFEFHDRRTDLAAPTSEMIERQAERYGQIFALFKEYRDVIQSVTFWGIADDHTWLDNFPVHGRKNWPLLFDEQHK
PKPAFWRAVSV
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9FKH A 1 ? 331 ? Q09LY9 1 ? 331 ? 1 331 
2 1 9FKH B 1 ? 331 ? Q09LY9 1 ? 331 ? 1 331 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FKH GLY A 241 ? UNP Q09LY9 GLU 241 'engineered mutation' 241 1 
2 9FKH GLY B 241 ? UNP Q09LY9 GLU 241 'engineered mutation' 241 2 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C 
2 1 B,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 7   ? PHE A 12  ? SER A 7   PHE A 12  1 ? 6  
HELX_P HELX_P2  AA2 ASN A 23  ? GLN A 30  ? ASN A 23  GLN A 30  1 ? 8  
HELX_P HELX_P3  AA3 GLN A 30  ? VAL A 38  ? GLN A 30  VAL A 38  1 ? 9  
HELX_P HELX_P4  AA4 LYS A 48  ? GLN A 53  ? LYS A 48  GLN A 53  1 ? 6  
HELX_P HELX_P5  AA5 PHE A 61  ? HIS A 74  ? PHE A 61  HIS A 74  1 ? 14 
HELX_P HELX_P6  AA6 PRO A 90  ? GLN A 95  ? PRO A 90  GLN A 95  5 ? 6  
HELX_P HELX_P7  AA7 SER A 103 ? TYR A 122 ? SER A 103 TYR A 122 1 ? 20 
HELX_P HELX_P8  AA8 SER A 147 ? GLY A 154 ? SER A 147 GLY A 154 1 ? 8  
HELX_P HELX_P9  AA9 ASP A 156 ? ASP A 169 ? ASP A 156 ASP A 169 1 ? 14 
HELX_P HELX_P10 AB1 PHE A 183 ? LYS A 200 ? PHE A 183 LYS A 200 1 ? 18 
HELX_P HELX_P11 AB2 SER A 219 ? SER A 232 ? SER A 219 SER A 232 1 ? 14 
HELX_P HELX_P12 AB3 THR A 260 ? TYR A 281 ? THR A 260 TYR A 281 1 ? 22 
HELX_P HELX_P13 AB4 THR A 298 ? ASN A 302 ? THR A 298 ASN A 302 5 ? 5  
HELX_P HELX_P14 AB5 LYS A 322 ? SER A 330 ? LYS A 322 SER A 330 1 ? 9  
HELX_P HELX_P15 AB6 SER B 7   ? PHE B 12  ? SER B 7   PHE B 12  1 ? 6  
HELX_P HELX_P16 AB7 ASN B 23  ? GLN B 30  ? ASN B 23  GLN B 30  1 ? 8  
HELX_P HELX_P17 AB8 GLN B 30  ? VAL B 38  ? GLN B 30  VAL B 38  1 ? 9  
HELX_P HELX_P18 AB9 LYS B 48  ? GLN B 53  ? LYS B 48  GLN B 53  1 ? 6  
HELX_P HELX_P19 AC1 PHE B 61  ? HIS B 74  ? PHE B 61  HIS B 74  1 ? 14 
HELX_P HELX_P20 AC2 PRO B 90  ? GLN B 95  ? PRO B 90  GLN B 95  5 ? 6  
HELX_P HELX_P21 AC3 SER B 103 ? TYR B 122 ? SER B 103 TYR B 122 1 ? 20 
HELX_P HELX_P22 AC4 SER B 147 ? GLY B 154 ? SER B 147 GLY B 154 1 ? 8  
HELX_P HELX_P23 AC5 ASP B 156 ? ASP B 169 ? ASP B 156 ASP B 169 1 ? 14 
HELX_P HELX_P24 AC6 PHE B 183 ? LYS B 200 ? PHE B 183 LYS B 200 1 ? 18 
HELX_P HELX_P25 AC7 SER B 219 ? SER B 232 ? SER B 219 SER B 232 1 ? 14 
HELX_P HELX_P26 AC8 THR B 260 ? TYR B 281 ? THR B 260 TYR B 281 1 ? 22 
HELX_P HELX_P27 AC9 THR B 298 ? ASN B 302 ? THR B 298 ASN B 302 5 ? 5  
HELX_P HELX_P28 AD1 LYS B 322 ? SER B 330 ? LYS B 322 SER B 330 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 81  A . ? HIS 81  A THR 82  A ? THR 82  A 1 -2.80  
2 ARG 217 A . ? ARG 217 A PRO 218 A ? PRO 218 A 1 -10.24 
3 PHE 303 A . ? PHE 303 A PRO 304 A ? PRO 304 A 1 0.93   
4 HIS 81  B . ? HIS 81  B THR 82  B ? THR 82  B 1 0.76   
5 ARG 217 B . ? ARG 217 B PRO 218 B ? PRO 218 B 1 -3.98  
6 PHE 303 B . ? PHE 303 B PRO 304 B ? PRO 304 B 1 -4.49  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 10 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel 
AA1 2 3  ? parallel 
AA1 3 4  ? parallel 
AA1 4 5  ? parallel 
AA1 5 6  ? parallel 
AA1 6 7  ? parallel 
AA1 7 8  ? parallel 
AA1 8 9  ? parallel 
AA1 9 10 ? parallel 
AA2 1 2  ? parallel 
AA2 2 3  ? parallel 
AA2 3 4  ? parallel 
AA2 4 5  ? parallel 
AA2 5 6  ? parallel 
AA2 6 7  ? parallel 
AA2 7 8  ? parallel 
AA2 8 9  ? parallel 
AA2 9 10 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  HIS A 212 ? SER A 214 ? HIS A 212 SER A 214 
AA1 2  VAL A 236 ? SER A 245 ? VAL A 236 SER A 245 
AA1 3  ILE A 285 ? PHE A 290 ? ILE A 285 PHE A 290 
AA1 4  ARG A 17  ? VAL A 22  ? ARG A 17  VAL A 22  
AA1 5  SER A 40  ? ALA A 43  ? SER A 40  ALA A 43  
AA1 6  ALA A 77  ? TRP A 85  ? ALA A 77  TRP A 85  
AA1 7  CYS A 128 ? ASN A 133 ? CYS A 128 ASN A 133 
AA1 8  LEU A 173 ? ASP A 178 ? LEU A 173 ASP A 178 
AA1 9  GLY A 206 ? MET A 209 ? GLY A 206 MET A 209 
AA1 10 VAL A 236 ? SER A 245 ? VAL A 236 SER A 245 
AA2 1  HIS B 212 ? SER B 214 ? HIS B 212 SER B 214 
AA2 2  VAL B 236 ? SER B 245 ? VAL B 236 SER B 245 
AA2 3  ILE B 285 ? PHE B 290 ? ILE B 285 PHE B 290 
AA2 4  ARG B 17  ? VAL B 22  ? ARG B 17  VAL B 22  
AA2 5  SER B 40  ? ALA B 43  ? SER B 40  ALA B 43  
AA2 6  ALA B 77  ? TRP B 85  ? ALA B 77  TRP B 85  
AA2 7  CYS B 128 ? ASN B 133 ? CYS B 128 ASN B 133 
AA2 8  LEU B 173 ? ASP B 178 ? LEU B 173 ASP B 178 
AA2 9  GLY B 206 ? MET B 209 ? GLY B 206 MET B 209 
AA2 10 VAL B 236 ? SER B 245 ? VAL B 236 SER B 245 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N TRP A 213 ? N TRP A 213 O SER A 245 ? O SER A 245 
AA1 2 3  N ILE A 239 ? N ILE A 239 O THR A 289 ? O THR A 289 
AA1 3 4  O VAL A 288 ? O VAL A 288 N ARG A 17  ? N ARG A 17  
AA1 4 5  N VAL A 22  ? N VAL A 22  O THR A 42  ? O THR A 42  
AA1 5 6  N ILE A 41  ? N ILE A 41  O ARG A 79  ? O ARG A 79  
AA1 6 7  N GLY A 80  ? N GLY A 80  O CYS A 128 ? O CYS A 128 
AA1 7 8  N TRP A 129 ? N TRP A 129 O PHE A 175 ? O PHE A 175 
AA1 8 9  N TYR A 176 ? N TYR A 176 O GLY A 208 ? O GLY A 208 
AA1 9 10 N MET A 209 ? N MET A 209 O HIS A 238 ? O HIS A 238 
AA2 1 2  N TRP B 213 ? N TRP B 213 O SER B 245 ? O SER B 245 
AA2 2 3  N ILE B 239 ? N ILE B 239 O THR B 289 ? O THR B 289 
AA2 3 4  O VAL B 288 ? O VAL B 288 N ARG B 17  ? N ARG B 17  
AA2 4 5  N VAL B 22  ? N VAL B 22  O THR B 42  ? O THR B 42  
AA2 5 6  N ILE B 41  ? N ILE B 41  O ARG B 79  ? O ARG B 79  
AA2 6 7  N GLY B 80  ? N GLY B 80  O CYS B 128 ? O CYS B 128 
AA2 7 8  N TRP B 129 ? N TRP B 129 O PHE B 175 ? O PHE B 175 
AA2 8 9  N TYR B 176 ? N TYR B 176 O GLY B 208 ? O GLY B 208 
AA2 9 10 N MET B 209 ? N MET B 209 O HIS B 238 ? O HIS B 238 
# 
_pdbx_entry_details.entry_id                   9FKH 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 527 ? ? O A HOH 560 ? ? 2.19 
2 1 OD1 A ASP 255 ? ? O A HOH 401 ? ? 2.19 
3 1 OD1 A ASP 255 ? ? O A HOH 402 ? ? 2.19 
4 1 O   A ARG 282 ? ? O A HOH 403 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 13  ? ? -39.65  -39.31  
2 1 ASN A 45  ? ? -144.00 -24.47  
3 1 ASP A 96  ? ? -102.42 -166.89 
4 1 ARG A 252 ? ? -98.96  36.45   
5 1 ILE A 293 ? ? -147.56 -31.39  
6 1 ARG A 308 ? ? -110.35 -161.97 
7 1 ILE B 293 ? ? -142.64 -31.69  
8 1 ASP B 295 ? ? -69.13  1.61    
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     615 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 692 ? 6.72 . 
2 1 O ? A HOH 693 ? 7.45 . 
3 1 O ? B HOH 647 ? 5.89 . 
4 1 O ? B HOH 648 ? 6.24 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1 ? A MET 1 
2 1 Y 1 A ASN 2 ? A ASN 2 
3 1 Y 1 B MET 1 ? B MET 1 
4 1 Y 1 B ASN 2 ? B ASN 2 
5 1 Y 1 B SER 3 ? B SER 3 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2Q8X 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FKH 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005906 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000194 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012466 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012671 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 3   ? -57.07363  -22.03599 -89.77126  1.000 87.03652 ? 3   SER A N   1 
ATOM   2    C CA  . SER A 1 3   ? -58.17546  -22.73569 -89.09908  1.000 72.78261 ? 3   SER A CA  1 
ATOM   3    C C   . SER A 1 3   ? -59.33487  -23.03350 -90.05112  1.000 66.30575 ? 3   SER A C   1 
ATOM   4    O O   . SER A 1 3   ? -59.53621  -24.18492 -90.45641  1.000 63.13802 ? 3   SER A O   1 
ATOM   5    C CB  . SER A 1 3   ? -58.66943  -21.90827 -87.90284  1.000 82.14768 ? 3   SER A CB  1 
ATOM   6    O OG  . SER A 1 3   ? -59.71872  -22.58843 -87.19828  1.000 88.00914 ? 3   SER A OG  1 
ATOM   7    N N   . SER A 1 4   ? -60.11583  -21.99471 -90.35695  1.000 58.10258 ? 4   SER A N   1 
ATOM   8    C CA  . SER A 1 4   ? -61.11716  -22.04179 -91.41370  1.000 59.74652 ? 4   SER A CA  1 
ATOM   9    C C   . SER A 1 4   ? -60.55207  -21.64420 -92.76576  1.000 51.44633 ? 4   SER A C   1 
ATOM   10   O O   . SER A 1 4   ? -61.29100  -21.68193 -93.75989  1.000 46.71198 ? 4   SER A O   1 
ATOM   11   C CB  . SER A 1 4   ? -62.30706  -21.12669 -91.08309  1.000 45.80519 ? 4   SER A CB  1 
ATOM   12   O OG  . SER A 1 4   ? -63.08857  -21.69720 -90.05471  1.000 61.14952 ? 4   SER A OG  1 
ATOM   13   N N   . LEU A 1 5   ? -59.26468  -21.26418 -92.82242  1.000 49.00791 ? 5   LEU A N   1 
ATOM   14   C CA  . LEU A 1 5   ? -58.65365  -20.85021 -94.07906  1.000 41.05008 ? 5   LEU A CA  1 
ATOM   15   C C   . LEU A 1 5   ? -58.58935  -22.02045 -95.05502  1.000 38.85607 ? 5   LEU A C   1 
ATOM   16   O O   . LEU A 1 5   ? -58.30534  -23.14966 -94.65016  1.000 36.36862 ? 5   LEU A O   1 
ATOM   17   C CB  . LEU A 1 5   ? -57.24105  -20.32538 -93.86164  1.000 36.57313 ? 5   LEU A CB  1 
ATOM   18   C CG  . LEU A 1 5   ? -57.04487  -18.90201 -93.35854  1.000 47.48652 ? 5   LEU A CG  1 
ATOM   19   C CD1 . LEU A 1 5   ? -55.56878  -18.53715 -93.43051  1.000 37.69652 ? 5   LEU A CD1 1 
ATOM   20   C CD2 . LEU A 1 5   ? -57.89327  -17.92443 -94.13604  1.000 38.73792 ? 5   LEU A CD2 1 
ATOM   21   N N   . PRO A 1 6   ? -58.83119  -21.78014 -96.34082  1.000 41.29072 ? 6   PRO A N   1 
ATOM   22   C CA  . PRO A 1 6   ? -58.51216  -22.79294 -97.35550  1.000 39.82177 ? 6   PRO A CA  1 
ATOM   23   C C   . PRO A 1 6   ? -57.00650  -22.99072 -97.48871  1.000 31.91596 ? 6   PRO A C   1 
ATOM   24   O O   . PRO A 1 6   ? -56.19862  -22.11178 -97.18325  1.000 25.80001 ? 6   PRO A O   1 
ATOM   25   C CB  . PRO A 1 6   ? -59.10905  -22.21857 -98.64646  1.000 33.00923 ? 6   PRO A CB  1 
ATOM   26   C CG  . PRO A 1 6   ? -60.02695  -21.10735 -98.20806  1.000 31.30186 ? 6   PRO A CG  1 
ATOM   27   C CD  . PRO A 1 6   ? -59.49036  -20.59308 -96.91230  1.000 33.20385 ? 6   PRO A CD  1 
ATOM   28   N N   . SER A 1 7   ? -56.63506  -24.17767 -97.95371  1.000 29.21055 ? 7   SER A N   1 
ATOM   29   C CA  . SER A 1 7   ? -55.23952  -24.54533 -98.13870  1.000 32.24686 ? 7   SER A CA  1 
ATOM   30   C C   . SER A 1 7   ? -54.86506  -24.41896 -99.61214  1.000 31.55367 ? 7   SER A C   1 
ATOM   31   O O   . SER A 1 7   ? -55.51536  -25.02479 -100.47562 1.000 29.53902 ? 7   SER A O   1 
ATOM   32   C CB  . SER A 1 7   ? -55.00248  -25.96893 -97.63845  1.000 26.21253 ? 7   SER A CB  1 
ATOM   33   O OG  . SER A 1 7   ? -53.84629  -26.52804 -98.21081  1.000 35.82512 ? 7   SER A OG  1 
ATOM   34   N N   . LEU A 1 8   ? -53.81641  -23.63474 -99.89079  1.000 27.39853 ? 8   LEU A N   1 
ATOM   35   C CA  . LEU A 1 8   ? -53.41169  -23.35558 -101.27080 1.000 26.75776 ? 8   LEU A CA  1 
ATOM   36   C C   . LEU A 1 8   ? -53.26785  -24.63366 -102.09113 1.000 28.44411 ? 8   LEU A C   1 
ATOM   37   O O   . LEU A 1 8   ? -53.84317  -24.75021 -103.18008 1.000 25.20350 ? 8   LEU A O   1 
ATOM   38   C CB  . LEU A 1 8   ? -52.09782  -22.57092 -101.27628 1.000 20.80708 ? 8   LEU A CB  1 
ATOM   39   C CG  . LEU A 1 8   ? -52.21555  -21.10995 -100.84938 1.000 27.90833 ? 8   LEU A CG  1 
ATOM   40   C CD1 . LEU A 1 8   ? -50.84528  -20.41668 -100.83211 1.000 18.24635 ? 8   LEU A CD1 1 
ATOM   41   C CD2 . LEU A 1 8   ? -53.16664  -20.39364 -101.78217 1.000 26.17881 ? 8   LEU A CD2 1 
ATOM   42   N N   . ARG A 1 9   ? -52.49122  -25.60744 -101.59508 1.000 26.56083 ? 9   ARG A N   1 
ATOM   43   C CA  . ARG A 1 9   ? -52.33234  -26.84911 -102.35567 1.000 28.84198 ? 9   ARG A CA  1 
ATOM   44   C C   . ARG A 1 9   ? -53.67573  -27.55771 -102.57478 1.000 25.60761 ? 9   ARG A C   1 
ATOM   45   O O   . ARG A 1 9   ? -53.86938  -28.21020 -103.60578 1.000 27.17323 ? 9   ARG A O   1 
ATOM   46   C CB  . ARG A 1 9   ? -51.31471  -27.78099 -101.66643 1.000 29.45439 ? 9   ARG A CB  1 
ATOM   47   C CG  . ARG A 1 9   ? -51.72763  -28.30290 -100.27851 1.000 24.56162 ? 9   ARG A CG  1 
ATOM   48   C CD  . ARG A 1 9   ? -50.80671  -29.40078 -99.73633  1.000 21.98532 ? 9   ARG A CD  1 
ATOM   49   N NE  . ARG A 1 9   ? -51.26065  -29.83316 -98.41885  1.000 25.97725 ? 9   ARG A NE  1 
ATOM   50   C CZ  . ARG A 1 9   ? -50.83269  -29.32526 -97.26365  1.000 28.77840 ? 9   ARG A CZ  1 
ATOM   51   N NH1 . ARG A 1 9   ? -49.91245  -28.37220 -97.24996  1.000 32.28087 ? 9   ARG A NH1 1 
ATOM   52   N NH2 . ARG A 1 9   ? -51.32742  -29.77170 -96.11594  1.000 28.11780 ? 9   ARG A NH2 1 
ATOM   53   N N   . ASP A 1 10  ? -54.61272  -27.44003 -101.63076 1.000 28.78647 ? 10  ASP A N   1 
ATOM   54   C CA  . ASP A 1 10  ? -55.90885  -28.10977 -101.78230 1.000 33.62652 ? 10  ASP A CA  1 
ATOM   55   C C   . ASP A 1 10  ? -56.77998  -27.38699 -102.79785 1.000 30.21366 ? 10  ASP A C   1 
ATOM   56   O O   . ASP A 1 10  ? -57.31376  -28.00389 -103.72423 1.000 29.51030 ? 10  ASP A O   1 
ATOM   57   C CB  . ASP A 1 10  ? -56.63416  -28.18507 -100.43843 1.000 35.25613 ? 10  ASP A CB  1 
ATOM   58   C CG  . ASP A 1 10  ? -56.08970  -29.26414 -99.54662  1.000 41.81652 ? 10  ASP A CG  1 
ATOM   59   O OD1 . ASP A 1 10  ? -55.52930  -30.23645 -100.09802 1.000 35.17070 ? 10  ASP A OD1 1 
ATOM   60   O OD2 . ASP A 1 10  ? -56.22983  -29.14059 -98.30607  1.000 45.32359 ? 10  ASP A OD2 1 
ATOM   61   N N   . VAL A 1 11  ? -56.93080  -26.07188 -102.62625 1.000 25.09698 ? 11  VAL A N   1 
ATOM   62   C CA  . VAL A 1 11  ? -57.61194  -25.23573 -103.60569 1.000 29.58133 ? 11  VAL A CA  1 
ATOM   63   C C   . VAL A 1 11  ? -57.17615  -25.59671 -105.01942 1.000 32.69710 ? 11  VAL A C   1 
ATOM   64   O O   . VAL A 1 11  ? -58.00883  -25.78478 -105.91611 1.000 22.92066 ? 11  VAL A O   1 
ATOM   65   C CB  . VAL A 1 11  ? -57.34560  -23.74970 -103.29580 1.000 32.34606 ? 11  VAL A CB  1 
ATOM   66   C CG1 . VAL A 1 11  ? -57.90356  -22.86682 -104.40860 1.000 30.72211 ? 11  VAL A CG1 1 
ATOM   67   C CG2 . VAL A 1 11  ? -57.92896  -23.37194 -101.93239 1.000 28.94472 ? 11  VAL A CG2 1 
ATOM   68   N N   . PHE A 1 12  ? -55.86814  -25.73444 -105.23797 1.000 28.57669 ? 12  PHE A N   1 
ATOM   69   C CA  . PHE A 1 12  ? -55.33987  -25.94286 -106.57829 1.000 28.88904 ? 12  PHE A CA  1 
ATOM   70   C C   . PHE A 1 12  ? -54.99536  -27.40218 -106.88041 1.000 28.22174 ? 12  PHE A C   1 
ATOM   71   O O   . PHE A 1 12  ? -54.41497  -27.68196 -107.93425 1.000 26.25559 ? 12  PHE A O   1 
ATOM   72   C CB  . PHE A 1 12  ? -54.14548  -25.01489 -106.79171 1.000 21.93381 ? 12  PHE A CB  1 
ATOM   73   C CG  . PHE A 1 12  ? -54.54278  -23.56835 -106.82479 1.000 25.27371 ? 12  PHE A CG  1 
ATOM   74   C CD1 . PHE A 1 12  ? -55.30506  -23.07147 -107.88736 1.000 26.83624 ? 12  PHE A CD1 1 
ATOM   75   C CD2 . PHE A 1 12  ? -54.23994  -22.72322 -105.77470 1.000 22.62990 ? 12  PHE A CD2 1 
ATOM   76   C CE1 . PHE A 1 12  ? -55.70871  -21.73796 -107.92383 1.000 17.70146 ? 12  PHE A CE1 1 
ATOM   77   C CE2 . PHE A 1 12  ? -54.64789  -21.38605 -105.80050 1.000 24.51365 ? 12  PHE A CE2 1 
ATOM   78   C CZ  . PHE A 1 12  ? -55.37955  -20.89468 -106.87746 1.000 18.98136 ? 12  PHE A CZ  1 
ATOM   79   N N   . ALA A 1 13  ? -55.41849  -28.33472 -106.02197 1.000 29.77755 ? 13  ALA A N   1 
ATOM   80   C CA  . ALA A 1 13  ? -55.17417  -29.76896 -106.16015 1.000 33.48371 ? 13  ALA A CA  1 
ATOM   81   C C   . ALA A 1 13  ? -55.29194  -30.25238 -107.59423 1.000 35.99984 ? 13  ALA A C   1 
ATOM   82   O O   . ALA A 1 13  ? -54.51631  -31.10330 -108.03601 1.000 41.02298 ? 13  ALA A O   1 
ATOM   83   C CB  . ALA A 1 13  ? -56.15477  -30.56268 -105.28791 1.000 22.63175 ? 13  ALA A CB  1 
ATOM   84   N N   . ASN A 1 14  ? -56.26609  -29.72300 -108.32376 1.000 36.43869 ? 14  ASN A N   1 
ATOM   85   C CA  . ASN A 1 14  ? -56.58969  -30.21345 -109.65237 1.000 37.69515 ? 14  ASN A CA  1 
ATOM   86   C C   . ASN A 1 14  ? -55.83330  -29.48173 -110.74461 1.000 39.48369 ? 14  ASN A C   1 
ATOM   87   O O   . ASN A 1 14  ? -55.96819  -29.83676 -111.92079 1.000 33.65931 ? 14  ASN A O   1 
ATOM   88   C CB  . ASN A 1 14  ? -58.09891  -30.09563 -109.88475 1.000 47.62444 ? 14  ASN A CB  1 
ATOM   89   C CG  . ASN A 1 14  ? -58.87928  -31.14902 -109.12327 1.000 56.04652 ? 14  ASN A CG  1 
ATOM   90   O OD1 . ASN A 1 14  ? -58.50115  -32.32350 -109.11296 1.000 53.74260 ? 14  ASN A OD1 1 
ATOM   91   N ND2 . ASN A 1 14  ? -59.95137  -30.73054 -108.44856 1.000 64.24658 ? 14  ASN A ND2 1 
ATOM   92   N N   . ASP A 1 15  ? -55.01544  -28.49812 -110.37623 1.000 31.19854 ? 15  ASP A N   1 
ATOM   93   C CA  . ASP A 1 15  ? -54.48845  -27.52918 -111.32113 1.000 25.56600 ? 15  ASP A CA  1 
ATOM   94   C C   . ASP A 1 15  ? -52.97497  -27.54773 -111.39113 1.000 32.22839 ? 15  ASP A C   1 
ATOM   95   O O   . ASP A 1 15  ? -52.40278  -27.69079 -112.48445 1.000 27.35037 ? 15  ASP A O   1 
ATOM   96   C CB  . ASP A 1 15  ? -55.00059  -26.13560 -110.92817 1.000 30.96912 ? 15  ASP A CB  1 
ATOM   97   C CG  . ASP A 1 15  ? -56.51814  -26.04766 -110.98572 1.000 33.74465 ? 15  ASP A CG  1 
ATOM   98   O OD1 . ASP A 1 15  ? -57.09150  -26.59044 -111.96125 1.000 29.95305 ? 15  ASP A OD1 1 
ATOM   99   O OD2 . ASP A 1 15  ? -57.13055  -25.46407 -110.05941 1.000 36.22556 ? 15  ASP A OD2 1 
ATOM   100  N N   . PHE A 1 16  ? -52.31061  -27.40709 -110.24985 1.000 31.07522 ? 16  PHE A N   1 
ATOM   101  C CA  . PHE A 1 16  ? -50.85827  -27.40245 -110.18755 1.000 24.93302 ? 16  PHE A CA  1 
ATOM   102  C C   . PHE A 1 16  ? -50.45411  -27.50259 -108.72714 1.000 27.21422 ? 16  PHE A C   1 
ATOM   103  O O   . PHE A 1 16  ? -51.23865  -27.20871 -107.81578 1.000 26.70940 ? 16  PHE A O   1 
ATOM   104  C CB  . PHE A 1 16  ? -50.26634  -26.13954 -110.83608 1.000 26.27011 ? 16  PHE A CB  1 
ATOM   105  C CG  . PHE A 1 16  ? -51.17022  -24.93526 -110.75609 1.000 25.11716 ? 16  PHE A CG  1 
ATOM   106  C CD1 . PHE A 1 16  ? -51.35478  -24.26912 -109.55459 1.000 25.46894 ? 16  PHE A CD1 1 
ATOM   107  C CD2 . PHE A 1 16  ? -51.84554  -24.47847 -111.88184 1.000 24.30307 ? 16  PHE A CD2 1 
ATOM   108  C CE1 . PHE A 1 16  ? -52.18835  -23.16653 -109.47908 1.000 24.97885 ? 16  PHE A CE1 1 
ATOM   109  C CE2 . PHE A 1 16  ? -52.68397  -23.38114 -111.81384 1.000 24.68192 ? 16  PHE A CE2 1 
ATOM   110  C CZ  . PHE A 1 16  ? -52.85896  -22.72208 -110.61399 1.000 26.77050 ? 16  PHE A CZ  1 
ATOM   111  N N   . ARG A 1 17  ? -49.22536  -27.94475 -108.52130 1.000 26.54684 ? 17  ARG A N   1 
ATOM   112  C CA  . ARG A 1 17  ? -48.62293  -27.87798 -107.20366 1.000 20.90844 ? 17  ARG A CA  1 
ATOM   113  C C   . ARG A 1 17  ? -48.40567  -26.42285 -106.81242 1.000 23.19231 ? 17  ARG A C   1 
ATOM   114  O O   . ARG A 1 17  ? -48.21527  -25.54597 -107.66224 1.000 23.69428 ? 17  ARG A O   1 
ATOM   115  C CB  . ARG A 1 17  ? -47.29832  -28.62761 -107.20501 1.000 30.74629 ? 17  ARG A CB  1 
ATOM   116  C CG  . ARG A 1 17  ? -47.43933  -30.11390 -107.44548 1.000 28.41504 ? 17  ARG A CG  1 
ATOM   117  C CD  . ARG A 1 17  ? -46.10907  -30.82466 -107.21642 1.000 31.42766 ? 17  ARG A CD  1 
ATOM   118  N NE  . ARG A 1 17  ? -46.23878  -32.27882 -107.24402 1.000 37.17910 ? 17  ARG A NE  1 
ATOM   119  C CZ  . ARG A 1 17  ? -46.40131  -33.02931 -106.15787 1.000 37.04189 ? 17  ARG A CZ  1 
ATOM   120  N NH1 . ARG A 1 17  ? -46.44617  -32.46096 -104.95104 1.000 32.79404 ? 17  ARG A NH1 1 
ATOM   121  N NH2 . ARG A 1 17  ? -46.51667  -34.34975 -106.27732 1.000 34.93535 ? 17  ARG A NH2 1 
ATOM   122  N N   . ILE A 1 18  ? -48.44143  -26.17420 -105.50932 1.000 18.61991 ? 18  ILE A N   1 
ATOM   123  C CA  . ILE A 1 18  ? -48.12237  -24.87834 -104.92055 1.000 21.33252 ? 18  ILE A CA  1 
ATOM   124  C C   . ILE A 1 18  ? -46.81608  -25.03368 -104.14221 1.000 27.25647 ? 18  ILE A C   1 
ATOM   125  O O   . ILE A 1 18  ? -46.70548  -25.91659 -103.27962 1.000 27.31879 ? 18  ILE A O   1 
ATOM   126  C CB  . ILE A 1 18  ? -49.26774  -24.39758 -104.01056 1.000 19.63285 ? 18  ILE A CB  1 
ATOM   127  C CG1 . ILE A 1 18  ? -50.57233  -24.27573 -104.81912 1.000 25.35534 ? 18  ILE A CG1 1 
ATOM   128  C CG2 . ILE A 1 18  ? -48.90513  -23.08614 -103.32609 1.000 21.05524 ? 18  ILE A CG2 1 
ATOM   129  C CD1 . ILE A 1 18  ? -50.56517  -23.17341 -105.91527 1.000 18.06049 ? 18  ILE A CD1 1 
ATOM   130  N N   . GLY A 1 19  ? -45.82905  -24.17132 -104.43601 1.000 21.93587 ? 19  GLY A N   1 
ATOM   131  C CA  . GLY A 1 19  ? -44.50536  -24.30764 -103.86993 1.000 19.42351 ? 19  GLY A CA  1 
ATOM   132  C C   . GLY A 1 19  ? -44.02982  -23.03268 -103.19091 1.000 22.32167 ? 19  GLY A C   1 
ATOM   133  O O   . GLY A 1 19  ? -44.61060  -21.95284 -103.35587 1.000 21.18492 ? 19  GLY A O   1 
ATOM   134  N N   . ALA A 1 20  ? -42.93900  -23.17623 -102.42919 1.000 17.79664 ? 20  ALA A N   1 
ATOM   135  C CA  . ALA A 1 20  ? -42.30798  -22.04408 -101.76880 1.000 18.13266 ? 20  ALA A CA  1 
ATOM   136  C C   . ALA A 1 20  ? -40.79639  -22.24734 -101.72676 1.000 24.90110 ? 20  ALA A C   1 
ATOM   137  O O   . ALA A 1 20  ? -40.31101  -23.36544 -101.51271 1.000 21.34389 ? 20  ALA A O   1 
ATOM   138  C CB  . ALA A 1 20  ? -42.84911  -21.85790 -100.35217 1.000 13.91910 ? 20  ALA A CB  1 
ATOM   139  N N   . ALA A 1 21  ? -40.05693  -21.15696 -101.92632 1.000 20.85777 ? 21  ALA A N   1 
ATOM   140  C CA  . ALA A 1 21  ? -38.61089  -21.16181 -101.78078 1.000 19.62130 ? 21  ALA A CA  1 
ATOM   141  C C   . ALA A 1 21  ? -38.25901  -20.89224 -100.32219 1.000 23.38887 ? 21  ALA A C   1 
ATOM   142  O O   . ALA A 1 21  ? -38.79999  -19.96724 -99.71376  1.000 30.78274 ? 21  ALA A O   1 
ATOM   143  C CB  . ALA A 1 21  ? -37.97762  -20.11161 -102.68781 1.000 15.76787 ? 21  ALA A CB  1 
ATOM   144  N N   . VAL A 1 22  ? -37.36590  -21.70941 -99.75779  1.000 26.80918 ? 22  VAL A N   1 
ATOM   145  C CA  . VAL A 1 22  ? -37.08094  -21.69847 -98.32660  1.000 25.98040 ? 22  VAL A CA  1 
ATOM   146  C C   . VAL A 1 22  ? -35.58091  -21.83776 -98.13375  1.000 26.55617 ? 22  VAL A C   1 
ATOM   147  O O   . VAL A 1 22  ? -34.82104  -22.04329 -99.08034  1.000 28.98230 ? 22  VAL A O   1 
ATOM   148  C CB  . VAL A 1 22  ? -37.80099  -22.83517 -97.56403  1.000 26.65683 ? 22  VAL A CB  1 
ATOM   149  C CG1 . VAL A 1 22  ? -39.33229  -22.75166 -97.74832  1.000 21.22648 ? 22  VAL A CG1 1 
ATOM   150  C CG2 . VAL A 1 22  ? -37.25612  -24.18890 -98.00200  1.000 22.70993 ? 22  VAL A CG2 1 
ATOM   151  N N   . ASN A 1 23  ? -35.16831  -21.71663 -96.88139  1.000 28.42790 ? 23  ASN A N   1 
ATOM   152  C CA  . ASN A 1 23  ? -33.83787  -22.06317 -96.41590  1.000 31.01704 ? 23  ASN A CA  1 
ATOM   153  C C   . ASN A 1 23  ? -34.03826  -22.62921 -95.01030  1.000 35.60249 ? 23  ASN A C   1 
ATOM   154  O O   . ASN A 1 23  ? -35.16053  -22.56035 -94.49170  1.000 29.58545 ? 23  ASN A O   1 
ATOM   155  C CB  . ASN A 1 23  ? -32.89931  -20.84839 -96.45880  1.000 31.28889 ? 23  ASN A CB  1 
ATOM   156  C CG  . ASN A 1 23  ? -33.35912  -19.69838 -95.57946  1.000 29.85037 ? 23  ASN A CG  1 
ATOM   157  O OD1 . ASN A 1 23  ? -33.85444  -19.90238 -94.47224  1.000 32.02295 ? 23  ASN A OD1 1 
ATOM   158  N ND2 . ASN A 1 23  ? -33.15715  -18.47227 -96.05833  1.000 28.51489 ? 23  ASN A ND2 1 
ATOM   159  N N   . PRO A 1 24  ? -33.01294  -23.21288 -94.37159  1.000 32.55133 ? 24  PRO A N   1 
ATOM   160  C CA  . PRO A 1 24  ? -33.23729  -23.80900 -93.04166  1.000 31.81045 ? 24  PRO A CA  1 
ATOM   161  C C   . PRO A 1 24  ? -33.86209  -22.85874 -92.02768  1.000 25.53146 ? 24  PRO A C   1 
ATOM   162  O O   . PRO A 1 24  ? -34.75906  -23.27461 -91.27586  1.000 27.79728 ? 24  PRO A O   1 
ATOM   163  C CB  . PRO A 1 24  ? -31.82227  -24.24480 -92.62544  1.000 35.06931 ? 24  PRO A CB  1 
ATOM   164  C CG  . PRO A 1 24  ? -31.16076  -24.58038 -93.91773  1.000 33.52712 ? 24  PRO A CG  1 
ATOM   165  C CD  . PRO A 1 24  ? -31.65131  -23.50856 -94.86946  1.000 39.15366 ? 24  PRO A CD  1 
ATOM   166  N N   . VAL A 1 25  ? -33.44686  -21.58742 -92.01478  1.000 26.69660 ? 25  VAL A N   1 
ATOM   167  C CA  . VAL A 1 25  ? -34.04069  -20.59856 -91.10763  1.000 25.56835 ? 25  VAL A CA  1 
ATOM   168  C C   . VAL A 1 25  ? -35.53139  -20.38188 -91.40791  1.000 33.40676 ? 25  VAL A C   1 
ATOM   169  O O   . VAL A 1 25  ? -36.38389  -20.51190 -90.51752  1.000 32.17645 ? 25  VAL A O   1 
ATOM   170  C CB  . VAL A 1 25  ? -33.25642  -19.27572 -91.17106  1.000 33.86468 ? 25  VAL A CB  1 
ATOM   171  C CG1 . VAL A 1 25  ? -34.04496  -18.15809 -90.49027  1.000 28.91634 ? 25  VAL A CG1 1 
ATOM   172  C CG2 . VAL A 1 25  ? -31.89842  -19.44469 -90.51876  1.000 30.42160 ? 25  VAL A CG2 1 
ATOM   173  N N   . THR A 1 26  ? -35.87597  -20.02153 -92.65610  1.000 30.27521 ? 26  THR A N   1 
ATOM   174  C CA  . THR A 1 26  ? -37.28617  -19.72724 -92.93959  1.000 24.12999 ? 26  THR A CA  1 
ATOM   175  C C   . THR A 1 26  ? -38.16998  -20.95266 -92.79398  1.000 26.14442 ? 26  THR A C   1 
ATOM   176  O O   . THR A 1 26  ? -39.37396  -20.79802 -92.55586  1.000 28.21401 ? 26  THR A O   1 
ATOM   177  C CB  . THR A 1 26  ? -37.49077  -19.11945 -94.33902  1.000 28.78315 ? 26  THR A CB  1 
ATOM   178  O OG1 . THR A 1 26  ? -37.22012  -20.09619 -95.35484  1.000 27.59151 ? 26  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 26  ? -36.59669  -17.90859 -94.54646  1.000 33.35237 ? 26  THR A CG2 1 
ATOM   180  N N   . ILE A 1 27  ? -37.62581  -22.16591 -92.94093  1.000 29.94380 ? 27  ILE A N   1 
ATOM   181  C CA  . ILE A 1 27  ? -38.42883  -23.35453 -92.63766  1.000 29.78251 ? 27  ILE A CA  1 
ATOM   182  C C   . ILE A 1 27  ? -38.88429  -23.32067 -91.18121  1.000 32.22316 ? 27  ILE A C   1 
ATOM   183  O O   . ILE A 1 27  ? -40.04802  -23.57935 -90.87050  1.000 35.65830 ? 27  ILE A O   1 
ATOM   184  C CB  . ILE A 1 27  ? -37.64339  -24.64384 -92.92871  1.000 37.45652 ? 27  ILE A CB  1 
ATOM   185  C CG1 . ILE A 1 27  ? -37.52421  -24.90943 -94.42527  1.000 34.17690 ? 27  ILE A CG1 1 
ATOM   186  C CG2 . ILE A 1 27  ? -38.32510  -25.82694 -92.23516  1.000 38.16954 ? 27  ILE A CG2 1 
ATOM   187  C CD1 . ILE A 1 27  ? -36.59731  -26.07541 -94.73970  1.000 31.70332 ? 27  ILE A CD1 1 
ATOM   188  N N   . GLU A 1 28  ? -37.96625  -23.01022 -90.26230  1.000 24.91820 ? 28  GLU A N   1 
ATOM   189  C CA  . GLU A 1 28  ? -38.35133  -22.86317 -88.85956  1.000 37.28585 ? 28  GLU A CA  1 
ATOM   190  C C   . GLU A 1 28  ? -39.32713  -21.70576 -88.67820  1.000 29.86319 ? 28  GLU A C   1 
ATOM   191  O O   . GLU A 1 28  ? -40.35972  -21.84551 -88.01652  1.000 30.04199 ? 28  GLU A O   1 
ATOM   192  C CB  . GLU A 1 28  ? -37.10975  -22.65601 -87.97477  1.000 40.67615 ? 28  GLU A CB  1 
ATOM   193  C CG  . GLU A 1 28  ? -36.18517  -23.88330 -87.86268  1.000 38.87720 ? 28  GLU A CG  1 
ATOM   194  C CD  . GLU A 1 28  ? -36.96056  -25.18995 -87.62784  1.000 48.72255 ? 28  GLU A CD  1 
ATOM   195  O OE1 . GLU A 1 28  ? -37.75466  -25.26928 -86.65639  1.000 52.03652 ? 28  GLU A OE1 1 
ATOM   196  O OE2 . GLU A 1 28  ? -36.78215  -26.13603 -88.43013  1.000 45.69271 ? 28  GLU A OE2 1 
ATOM   197  N N   . MET A 1 29  ? -39.01956  -20.55739 -89.28352  1.000 28.07682 ? 29  MET A N   1 
ATOM   198  C CA  . MET A 1 29  ? -39.76508  -19.33348 -89.01006  1.000 27.28187 ? 29  MET A CA  1 
ATOM   199  C C   . MET A 1 29  ? -41.17093  -19.37039 -89.59953  1.000 27.09859 ? 29  MET A C   1 
ATOM   200  O O   . MET A 1 29  ? -42.08772  -18.76319 -89.03689  1.000 30.83902 ? 29  MET A O   1 
ATOM   201  C CB  . MET A 1 29  ? -38.96740  -18.13803 -89.53714  1.000 29.41581 ? 29  MET A CB  1 
ATOM   202  C CG  . MET A 1 29  ? -39.57791  -16.76570 -89.31222  1.000 38.09913 ? 29  MET A CG  1 
ATOM   203  S SD  . MET A 1 29  ? -38.53561  -15.48667 -90.06335  1.000 48.10576 ? 29  MET A SD  1 
ATOM   204  C CE  . MET A 1 29  ? -39.17875  -15.50417 -91.73941  1.000 36.95468 ? 29  MET A CE  1 
ATOM   205  N N   . GLN A 1 30  ? -41.37275  -20.09275 -90.70384  1.000 26.43826 ? 30  GLN A N   1 
ATOM   206  C CA  . GLN A 1 30  ? -42.65188  -20.12186 -91.40845  1.000 29.38872 ? 30  GLN A CA  1 
ATOM   207  C C   . GLN A 1 30  ? -43.18854  -21.53602 -91.49501  1.000 28.60205 ? 30  GLN A C   1 
ATOM   208  O O   . GLN A 1 30  ? -43.97321  -21.84702 -92.39492  1.000 33.18506 ? 30  GLN A O   1 
ATOM   209  C CB  . GLN A 1 30  ? -42.52899  -19.52930 -92.81440  1.000 20.85069 ? 30  GLN A CB  1 
ATOM   210  C CG  . GLN A 1 30  ? -41.93351  -18.11852 -92.82076  1.000 24.12811 ? 30  GLN A CG  1 
ATOM   211  C CD  . GLN A 1 30  ? -41.49724  -17.66639 -94.19022  1.000 30.68091 ? 30  GLN A CD  1 
ATOM   212  O OE1 . GLN A 1 30  ? -40.91885  -18.44021 -94.95575  1.000 30.44566 ? 30  GLN A OE1 1 
ATOM   213  N NE2 . GLN A 1 30  ? -41.77811  -16.40306 -94.51675  1.000 28.26533 ? 30  GLN A NE2 1 
ATOM   214  N N   . LYS A 1 31  ? -42.75735  -22.39844 -90.56689  1.000 25.25185 ? 31  LYS A N   1 
ATOM   215  C CA  . LYS A 1 31  ? -43.05991  -23.82449 -90.66496  1.000 29.47357 ? 31  LYS A CA  1 
ATOM   216  C C   . LYS A 1 31  ? -44.54514  -24.09254 -90.85157  1.000 31.31583 ? 31  LYS A C   1 
ATOM   217  O O   . LYS A 1 31  ? -44.93112  -24.94595 -91.66063  1.000 35.55319 ? 31  LYS A O   1 
ATOM   218  C CB  . LYS A 1 31  ? -42.55025  -24.55172 -89.42266  1.000 30.37056 ? 31  LYS A CB  1 
ATOM   219  C CG  . LYS A 1 31  ? -42.53026  -26.06501 -89.55557  1.000 35.53848 ? 31  LYS A CG  1 
ATOM   220  C CD  . LYS A 1 31  ? -41.82684  -26.70112 -88.36153  1.000 40.81252 ? 31  LYS A CD  1 
ATOM   221  C CE  . LYS A 1 31  ? -40.33966  -26.37374 -88.37549  1.000 43.16007 ? 31  LYS A CE  1 
ATOM   222  N NZ  . LYS A 1 31  ? -39.61962  -26.86359 -87.15319  1.000 51.14652 ? 31  LYS A NZ  1 
ATOM   223  N N   . GLN A 1 32  ? -45.39969  -23.38565 -90.11365  1.000 28.97134 ? 32  GLN A N   1 
ATOM   224  C CA  . GLN A 1 32  ? -46.80599  -23.75996 -90.13686  1.000 29.84887 ? 32  GLN A CA  1 
ATOM   225  C C   . GLN A 1 32  ? -47.44967  -23.37301 -91.45949  1.000 24.95071 ? 32  GLN A C   1 
ATOM   226  O O   . GLN A 1 32  ? -48.23555  -24.14981 -92.01909  1.000 26.46753 ? 32  GLN A O   1 
ATOM   227  C CB  . GLN A 1 32  ? -47.55151  -23.13734 -88.95957  1.000 33.52376 ? 32  GLN A CB  1 
ATOM   228  C CG  . GLN A 1 32  ? -48.91797  -23.80686 -88.69858  1.000 32.11352 ? 32  GLN A CG  1 
ATOM   229  C CD  . GLN A 1 32  ? -48.78433  -25.26795 -88.26576  1.000 43.44652 ? 32  GLN A CD  1 
ATOM   230  O OE1 . GLN A 1 32  ? -47.89640  -25.60991 -87.48464  1.000 46.93820 ? 32  GLN A OE1 1 
ATOM   231  N NE2 . GLN A 1 32  ? -49.67399  -26.13192 -88.76765  1.000 30.33316 ? 32  GLN A NE2 1 
ATOM   232  N N   . LEU A 1 33  ? -47.12019  -22.18353 -91.98454  1.000 28.08867 ? 33  LEU A N   1 
ATOM   233  C CA  . LEU A 1 33  ? -47.61132  -21.80050 -93.31170  1.000 28.05943 ? 33  LEU A CA  1 
ATOM   234  C C   . LEU A 1 33  ? -47.26522  -22.86722 -94.32915  1.000 29.38918 ? 33  LEU A C   1 
ATOM   235  O O   . LEU A 1 33  ? -48.13046  -23.33890 -95.07864  1.000 26.87125 ? 33  LEU A O   1 
ATOM   236  C CB  . LEU A 1 33  ? -47.01216  -20.46914 -93.74100  1.000 24.96122 ? 33  LEU A CB  1 
ATOM   237  C CG  . LEU A 1 33  ? -47.68541  -19.20039 -93.25001  1.000 30.94950 ? 33  LEU A CG  1 
ATOM   238  C CD1 . LEU A 1 33  ? -46.87039  -17.99173 -93.65438  1.000 24.80076 ? 33  LEU A CD1 1 
ATOM   239  C CD2 . LEU A 1 33  ? -49.08964  -19.13886 -93.83716  1.000 29.90311 ? 33  LEU A CD2 1 
ATOM   240  N N   . LEU A 1 34  ? -45.99279  -23.29191 -94.33149  1.000 29.12367 ? 34  LEU A N   1 
ATOM   241  C CA  . LEU A 1 34  ? -45.54314  -24.30264 -95.27911  1.000 23.87447 ? 34  LEU A CA  1 
ATOM   242  C C   . LEU A 1 34  ? -46.34300  -25.58532 -95.12279  1.000 27.04241 ? 34  LEU A C   1 
ATOM   243  O O   . LEU A 1 34  ? -46.84295  -26.14479 -96.10384  1.000 28.27493 ? 34  LEU A O   1 
ATOM   244  C CB  . LEU A 1 34  ? -44.04830  -24.56442 -95.08769  1.000 29.97813 ? 34  LEU A CB  1 
ATOM   245  C CG  . LEU A 1 34  ? -43.18746  -23.32285 -95.33641  1.000 27.61391 ? 34  LEU A CG  1 
ATOM   246  C CD1 . LEU A 1 34  ? -41.83076  -23.44925 -94.64230  1.000 28.13189 ? 34  LEU A CD1 1 
ATOM   247  C CD2 . LEU A 1 34  ? -43.04692  -23.06793 -96.84265  1.000 16.06368 ? 34  LEU A CD2 1 
ATOM   248  N N   . ILE A 1 35  ? -46.50950  -26.04351 -93.88583  1.000 24.47470 ? 35  ILE A N   1 
ATOM   249  C CA  . ILE A 1 35  ? -47.22405  -27.29160 -93.65369  1.000 28.35569 ? 35  ILE A CA  1 
ATOM   250  C C   . ILE A 1 35  ? -48.68488  -27.16493 -94.07609  1.000 34.10538 ? 35  ILE A C   1 
ATOM   251  O O   . ILE A 1 35  ? -49.28059  -28.11869 -94.59663  1.000 35.04599 ? 35  ILE A O   1 
ATOM   252  C CB  . ILE A 1 35  ? -47.07705  -27.70181 -92.17785  1.000 36.78653 ? 35  ILE A CB  1 
ATOM   253  C CG1 . ILE A 1 35  ? -45.62040  -28.10950 -91.90283  1.000 34.94092 ? 35  ILE A CG1 1 
ATOM   254  C CG2 . ILE A 1 35  ? -48.05947  -28.80566 -91.82946  1.000 29.10975 ? 35  ILE A CG2 1 
ATOM   255  C CD1 . ILE A 1 35  ? -45.29675  -28.33524 -90.44040  1.000 29.95563 ? 35  ILE A CD1 1 
ATOM   256  N N   . ASP A 1 36  ? -49.28353  -25.98308 -93.89755  1.000 26.44385 ? 36  ASP A N   1 
ATOM   257  C CA  . ASP A 1 36  ? -50.70957  -25.88074 -94.21007  1.000 31.00674 ? 36  ASP A CA  1 
ATOM   258  C C   . ASP A 1 36  ? -50.98594  -25.66762 -95.69324  1.000 30.87459 ? 36  ASP A C   1 
ATOM   259  O O   . ASP A 1 36  ? -52.08262  -26.00094 -96.14916  1.000 32.44549 ? 36  ASP A O   1 
ATOM   260  C CB  . ASP A 1 36  ? -51.37396  -24.74526 -93.42082  1.000 31.45949 ? 36  ASP A CB  1 
ATOM   261  C CG  . ASP A 1 36  ? -51.44277  -25.02261 -91.91943  1.000 33.40468 ? 36  ASP A CG  1 
ATOM   262  O OD1 . ASP A 1 36  ? -51.48208  -26.20502 -91.51878  1.000 32.10233 ? 36  ASP A OD1 1 
ATOM   263  O OD2 . ASP A 1 36  ? -51.45879  -24.04512 -91.13635  1.000 39.89429 ? 36  ASP A OD2 1 
ATOM   264  N N   . HIS A 1 37  ? -50.02098  -25.15683 -96.46536  1.000 30.64274 ? 37  HIS A N   1 
ATOM   265  C CA  . HIS A 1 37  ? -50.36400  -24.62244 -97.77722  1.000 29.65519 ? 37  HIS A CA  1 
ATOM   266  C C   . HIS A 1 37  ? -49.63184  -25.24907 -98.95407  1.000 30.53119 ? 37  HIS A C   1 
ATOM   267  O O   . HIS A 1 37  ? -50.25889  -25.45239 -100.00116 1.000 31.55133 ? 37  HIS A O   1 
ATOM   268  C CB  . HIS A 1 37  ? -50.14463  -23.10658 -97.77773  1.000 25.44222 ? 37  HIS A CB  1 
ATOM   269  C CG  . HIS A 1 37  ? -51.13932  -22.37663 -96.93489  1.000 29.72136 ? 37  HIS A CG  1 
ATOM   270  N ND1 . HIS A 1 37  ? -52.49144  -22.40075 -97.20519  1.000 27.68588 ? 37  HIS A ND1 1 
ATOM   271  C CD2 . HIS A 1 37  ? -50.99049  -21.62982 -95.81346  1.000 26.41054 ? 37  HIS A CD2 1 
ATOM   272  C CE1 . HIS A 1 37  ? -53.13053  -21.68550 -96.29475  1.000 29.07666 ? 37  HIS A CE1 1 
ATOM   273  N NE2 . HIS A 1 37  ? -52.24370  -21.20634 -95.43939  1.000 31.11355 ? 37  HIS A NE2 1 
ATOM   274  N N   . VAL A 1 38  ? -48.31876  -25.56292 -98.83839  1.000 26.73161 ? 38  VAL A N   1 
ATOM   275  C CA  . VAL A 1 38  ? -47.52674  -25.94208 -100.00991 1.000 24.86323 ? 38  VAL A CA  1 
ATOM   276  C C   . VAL A 1 38  ? -47.40742  -27.45731 -100.10908 1.000 24.88698 ? 38  VAL A C   1 
ATOM   277  O O   . VAL A 1 38  ? -47.52770  -28.18786 -99.11642  1.000 25.90893 ? 38  VAL A O   1 
ATOM   278  C CB  . VAL A 1 38  ? -46.13806  -25.26523 -100.00615 1.000 24.69234 ? 38  VAL A CB  1 
ATOM   279  C CG1 . VAL A 1 38  ? -46.27439  -23.78381 -99.67828  1.000 21.50508 ? 38  VAL A CG1 1 
ATOM   280  C CG2 . VAL A 1 38  ? -45.15665  -25.95535 -99.02376  1.000 20.72518 ? 38  VAL A CG2 1 
ATOM   281  N N   . ASN A 1 39  ? -47.21516  -27.94228 -101.33975 1.000 22.42295 ? 39  ASN A N   1 
ATOM   282  C CA  . ASN A 1 39  ? -46.81828  -29.33075 -101.56015 1.000 26.21296 ? 39  ASN A CA  1 
ATOM   283  C C   . ASN A 1 39  ? -45.57463  -29.40275 -102.43934 1.000 20.88624 ? 39  ASN A C   1 
ATOM   284  O O   . ASN A 1 39  ? -45.31802  -30.43443 -103.07543 1.000 23.25508 ? 39  ASN A O   1 
ATOM   285  C CB  . ASN A 1 39  ? -47.94838  -30.18092 -102.15981 1.000 20.02728 ? 39  ASN A CB  1 
ATOM   286  C CG  . ASN A 1 39  ? -48.55140  -29.57119 -103.41332 1.000 27.70700 ? 39  ASN A CG  1 
ATOM   287  O OD1 . ASN A 1 39  ? -48.05819  -28.56762 -103.93187 1.000 32.82685 ? 39  ASN A OD1 1 
ATOM   288  N ND2 . ASN A 1 39  ? -49.61210  -30.18756 -103.91697 1.000 20.70270 ? 39  ASN A ND2 1 
ATOM   289  N N   . SER A 1 40  ? -44.79961  -28.32174 -102.48028 1.000 24.43812 ? 40  SER A N   1 
ATOM   290  C CA  . SER A 1 40  ? -43.54274  -28.28032 -103.20734 1.000 19.08504 ? 40  SER A CA  1 
ATOM   291  C C   . SER A 1 40  ? -42.63827  -27.25861 -102.53728 1.000 24.17571 ? 40  SER A C   1 
ATOM   292  O O   . SER A 1 40  ? -43.10126  -26.26331 -101.96788 1.000 19.42889 ? 40  SER A O   1 
ATOM   293  C CB  . SER A 1 40  ? -43.74500  -27.94856 -104.69559 1.000 22.44398 ? 40  SER A CB  1 
ATOM   294  O OG  . SER A 1 40  ? -42.51523  -27.92117 -105.41051 1.000 23.84536 ? 40  SER A OG  1 
ATOM   295  N N   . ILE A 1 41  ? -41.33795  -27.52354 -102.61156 1.000 20.49532 ? 41  ILE A N   1 
ATOM   296  C CA  . ILE A 1 41  ? -40.32186  -26.72248 -101.95007 1.000 24.41439 ? 41  ILE A CA  1 
ATOM   297  C C   . ILE A 1 41  ? -39.15861  -26.53950 -102.91295 1.000 20.04328 ? 41  ILE A C   1 
ATOM   298  O O   . ILE A 1 41  ? -38.76964  -27.48368 -103.61364 1.000 23.12308 ? 41  ILE A O   1 
ATOM   299  C CB  . ILE A 1 41  ? -39.84553  -27.41570 -100.65402 1.000 25.32055 ? 41  ILE A CB  1 
ATOM   300  C CG1 . ILE A 1 41  ? -40.93183  -27.34870 -99.57648  1.000 28.75827 ? 41  ILE A CG1 1 
ATOM   301  C CG2 . ILE A 1 41  ? -38.58880  -26.78124 -100.14734 1.000 19.40489 ? 41  ILE A CG2 1 
ATOM   302  C CD1 . ILE A 1 41  ? -41.08979  -25.97649 -98.97304  1.000 27.61189 ? 41  ILE A CD1 1 
ATOM   303  N N   . THR A 1 42  ? -38.60395  -25.33157 -102.93966 1.000 25.81652 ? 42  THR A N   1 
ATOM   304  C CA  . THR A 1 42  ? -37.37343  -25.03344 -103.64502 1.000 25.81652 ? 42  THR A CA  1 
ATOM   305  C C   . THR A 1 42  ? -36.42078  -24.38024 -102.65149 1.000 26.53263 ? 42  THR A C   1 
ATOM   306  O O   . THR A 1 42  ? -36.85078  -23.67522 -101.73234 1.000 25.81652 ? 42  THR A O   1 
ATOM   307  C CB  . THR A 1 42  ? -37.60300  -24.09668 -104.84589 1.000 25.81652 ? 42  THR A CB  1 
ATOM   308  O OG1 . THR A 1 42  ? -38.66429  -24.60373 -105.68278 1.000 25.81652 ? 42  THR A OG1 1 
ATOM   309  C CG2 . THR A 1 42  ? -36.32618  -23.90588 -105.63009 1.000 25.81652 ? 42  THR A CG2 1 
ATOM   310  N N   . ALA A 1 43  ? -35.12025  -24.65865 -102.81493 1.000 21.45659 ? 43  ALA A N   1 
ATOM   311  C CA  . ALA A 1 43  ? -34.08732  -23.97420 -102.04734 1.000 21.11566 ? 43  ALA A CA  1 
ATOM   312  C C   . ALA A 1 43  ? -33.86296  -22.59098 -102.62978 1.000 19.41325 ? 43  ALA A C   1 
ATOM   313  O O   . ALA A 1 43  ? -33.53720  -22.45319 -103.81181 1.000 28.11153 ? 43  ALA A O   1 
ATOM   314  C CB  . ALA A 1 43  ? -32.77726  -24.77433 -102.06139 1.000 16.37052 ? 43  ALA A CB  1 
ATOM   315  N N   . GLU A 1 44  ? -34.01066  -21.56301 -101.79583 1.000 20.06904 ? 44  GLU A N   1 
ATOM   316  C CA  . GLU A 1 44  ? -33.83021  -20.20006 -102.28188 1.000 22.12311 ? 44  GLU A CA  1 
ATOM   317  C C   . GLU A 1 44  ? -32.38392  -19.92953 -102.68911 1.000 25.75334 ? 44  GLU A C   1 
ATOM   318  O O   . GLU A 1 44  ? -32.12790  -19.18572 -103.65021 1.000 28.47797 ? 44  GLU A O   1 
ATOM   319  C CB  . GLU A 1 44  ? -34.30072  -19.19518 -101.22373 1.000 22.76706 ? 44  GLU A CB  1 
ATOM   320  C CG  . GLU A 1 44  ? -34.41013  -17.79460 -101.78587 1.000 23.39361 ? 44  GLU A CG  1 
ATOM   321  C CD  . GLU A 1 44  ? -34.69503  -16.76153 -100.73329 1.000 23.56863 ? 44  GLU A CD  1 
ATOM   322  O OE1 . GLU A 1 44  ? -35.02499  -17.14517 -99.60212  1.000 23.32885 ? 44  GLU A OE1 1 
ATOM   323  O OE2 . GLU A 1 44  ? -34.55449  -15.56038 -101.03853 1.000 31.76350 ? 44  GLU A OE2 1 
ATOM   324  N N   . ASN A 1 45  ? -31.41577  -20.52153 -101.97051 1.000 27.12404 ? 45  ASN A N   1 
ATOM   325  C CA  . ASN A 1 45  ? -29.99555  -20.33074 -102.27703 1.000 21.77294 ? 45  ASN A CA  1 
ATOM   326  C C   . ASN A 1 45  ? -29.13427  -21.55736 -102.05750 1.000 30.30505 ? 45  ASN A C   1 
ATOM   327  O O   . ASN A 1 45  ? -28.06679  -21.66640 -102.67474 1.000 26.36256 ? 45  ASN A O   1 
ATOM   328  C CB  . ASN A 1 45  ? -29.39982  -19.20792 -101.43135 1.000 24.44906 ? 45  ASN A CB  1 
ATOM   329  C CG  . ASN A 1 45  ? -29.90373  -17.87632 -101.81801 1.000 26.72322 ? 45  ASN A CG  1 
ATOM   330  O OD1 . ASN A 1 45  ? -29.56365  -17.36994 -102.87943 1.000 26.45264 ? 45  ASN A OD1 1 
ATOM   331  N ND2 . ASN A 1 45  ? -30.71608  -17.28074 -100.96497 1.000 23.37109 ? 45  ASN A ND2 1 
ATOM   332  N N   . HIS A 1 46  ? -29.53238  -22.48320 -101.20269 1.000 26.95420 ? 46  HIS A N   1 
ATOM   333  C CA  . HIS A 1 46  ? -28.59572  -23.49408 -100.73425 1.000 25.18211 ? 46  HIS A CA  1 
ATOM   334  C C   . HIS A 1 46  ? -28.44934  -24.68496 -101.66896 1.000 24.48251 ? 46  HIS A C   1 
ATOM   335  O O   . HIS A 1 46  ? -27.87250  -25.70167 -101.26594 1.000 29.83070 ? 46  HIS A O   1 
ATOM   336  C CB  . HIS A 1 46  ? -28.97882  -23.93128 -99.31528  1.000 23.92939 ? 46  HIS A CB  1 
ATOM   337  C CG  . HIS A 1 46  ? -28.68889  -22.87738 -98.29346  1.000 33.51145 ? 46  HIS A CG  1 
ATOM   338  N ND1 . HIS A 1 46  ? -29.66395  -22.06107 -97.76396  1.000 32.50186 ? 46  HIS A ND1 1 
ATOM   339  C CD2 . HIS A 1 46  ? -27.52819  -22.51829 -97.68811  1.000 30.83843 ? 46  HIS A CD2 1 
ATOM   340  C CE1 . HIS A 1 46  ? -29.11846  -21.23760 -96.88719  1.000 33.21278 ? 46  HIS A CE1 1 
ATOM   341  N NE2 . HIS A 1 46  ? -27.82461  -21.49678 -96.81915  1.000 38.13379 ? 46  HIS A NE2 1 
ATOM   342  N N   . MET A 1 47  ? -28.91072  -24.58251 -102.90543 1.000 22.58255 ? 47  MET A N   1 
ATOM   343  C CA  . MET A 1 47  ? -28.57015  -25.57155 -103.90703 1.000 20.75399 ? 47  MET A CA  1 
ATOM   344  C C   . MET A 1 47  ? -27.92938  -24.90652 -105.11868 1.000 25.51568 ? 47  MET A C   1 
ATOM   345  O O   . MET A 1 47  ? -27.77940  -25.53695 -106.17533 1.000 22.47181 ? 47  MET A O   1 
ATOM   346  C CB  . MET A 1 47  ? -29.80482  -26.39215 -104.28342 1.000 20.92746 ? 47  MET A CB  1 
ATOM   347  C CG  . MET A 1 47  ? -30.15866  -27.51446 -103.28568 1.000 18.56299 ? 47  MET A CG  1 
ATOM   348  S SD  . MET A 1 47  ? -31.56719  -28.48855 -103.90403 1.000 21.47283 ? 47  MET A SD  1 
ATOM   349  C CE  . MET A 1 47  ? -32.19784  -29.24480 -102.39962 1.000 17.85254 ? 47  MET A CE  1 
ATOM   350  N N   . LYS A 1 48  ? -27.55081  -23.64132 -104.99212 1.000 24.28706 ? 48  LYS A N   1 
ATOM   351  C CA  . LYS A 1 48  ? -26.74260  -23.01349 -106.02211 1.000 26.01332 ? 48  LYS A CA  1 
ATOM   352  C C   . LYS A 1 48  ? -25.28260  -23.44732 -105.86518 1.000 28.55620 ? 48  LYS A C   1 
ATOM   353  O O   . LYS A 1 48  ? -24.87591  -23.97033 -104.82239 1.000 25.91439 ? 48  LYS A O   1 
ATOM   354  C CB  . LYS A 1 48  ? -26.89927  -21.49940 -105.95091 1.000 25.37344 ? 48  LYS A CB  1 
ATOM   355  C CG  . LYS A 1 48  ? -28.36936  -21.07510 -106.01521 1.000 22.15628 ? 48  LYS A CG  1 
ATOM   356  C CD  . LYS A 1 48  ? -28.55623  -19.60691 -105.71376 1.000 26.50534 ? 48  LYS A CD  1 
ATOM   357  C CE  . LYS A 1 48  ? -29.93667  -19.11690 -106.14558 1.000 24.68968 ? 48  LYS A CE  1 
ATOM   358  N NZ  . LYS A 1 48  ? -30.21820  -17.80490 -105.50053 1.000 34.03279 ? 48  LYS A NZ  1 
ATOM   359  N N   . PHE A 1 49  ? -24.49886  -23.25564 -106.93142 1.000 27.09323 ? 49  PHE A N   1 
ATOM   360  C CA  . PHE A 1 49  ? -23.15140  -23.82816 -106.97854 1.000 30.63729 ? 49  PHE A CA  1 
ATOM   361  C C   . PHE A 1 49  ? -22.32701  -23.44599 -105.74625 1.000 27.15989 ? 49  PHE A C   1 
ATOM   362  O O   . PHE A 1 49  ? -21.69422  -24.30076 -105.11404 1.000 24.89449 ? 49  PHE A O   1 
ATOM   363  C CB  . PHE A 1 49  ? -22.44488  -23.39023 -108.26980 1.000 24.75579 ? 49  PHE A CB  1 
ATOM   364  C CG  . PHE A 1 49  ? -21.30716  -24.30721 -108.69981 1.000 26.74301 ? 49  PHE A CG  1 
ATOM   365  C CD1 . PHE A 1 49  ? -20.14431  -24.39888 -107.95148 1.000 22.02431 ? 49  PHE A CD1 1 
ATOM   366  C CD2 . PHE A 1 49  ? -21.40238  -25.05699 -109.86806 1.000 25.03262 ? 49  PHE A CD2 1 
ATOM   367  C CE1 . PHE A 1 49  ? -19.10611  -25.23365 -108.33937 1.000 23.36316 ? 49  PHE A CE1 1 
ATOM   368  C CE2 . PHE A 1 49  ? -20.35816  -25.88143 -110.27984 1.000 27.95055 ? 49  PHE A CE2 1 
ATOM   369  C CZ  . PHE A 1 49  ? -19.20931  -25.97357 -109.50886 1.000 29.31557 ? 49  PHE A CZ  1 
ATOM   370  N N   . GLU A 1 50  ? -22.33745  -22.16262 -105.38157 1.000 26.78759 ? 50  GLU A N   1 
ATOM   371  C CA  . GLU A 1 50  ? -21.45464  -21.68539 -104.32801 1.000 28.18789 ? 50  GLU A CA  1 
ATOM   372  C C   . GLU A 1 50  ? -21.81792  -22.24781 -102.96185 1.000 30.86692 ? 50  GLU A C   1 
ATOM   373  O O   . GLU A 1 50  ? -20.99232  -22.18590 -102.04294 1.000 28.70613 ? 50  GLU A O   1 
ATOM   374  C CB  . GLU A 1 50  ? -21.47458  -20.16168 -104.27220 1.000 32.22366 ? 50  GLU A CB  1 
ATOM   375  C CG  . GLU A 1 50  ? -22.76887  -19.58610 -103.71737 1.000 31.93774 ? 50  GLU A CG  1 
ATOM   376  C CD  . GLU A 1 50  ? -22.75272  -18.07183 -103.64296 1.000 30.77358 ? 50  GLU A CD  1 
ATOM   377  O OE1 . GLU A 1 50  ? -21.77823  -17.46615 -104.12846 1.000 35.74530 ? 50  GLU A OE1 1 
ATOM   378  O OE2 . GLU A 1 50  ? -23.71424  -17.49085 -103.09598 1.000 37.79797 ? 50  GLU A OE2 1 
ATOM   379  N N   . HIS A 1 51  ? -23.02375  -22.79097 -102.80487 1.000 25.08111 ? 51  HIS A N   1 
ATOM   380  C CA  . HIS A 1 51  ? -23.44875  -23.35924 -101.53703 1.000 23.80526 ? 51  HIS A CA  1 
ATOM   381  C C   . HIS A 1 51  ? -23.38431  -24.88151 -101.52406 1.000 21.08986 ? 51  HIS A C   1 
ATOM   382  O O   . HIS A 1 51  ? -23.62519  -25.49186 -100.47750 1.000 23.14345 ? 51  HIS A O   1 
ATOM   383  C CB  . HIS A 1 51  ? -24.86917  -22.87685 -101.18982 1.000 26.23000 ? 51  HIS A CB  1 
ATOM   384  C CG  . HIS A 1 51  ? -24.94180  -21.42434 -100.83369 1.000 25.00960 ? 51  HIS A CG  1 
ATOM   385  N ND1 . HIS A 1 51  ? -24.30105  -20.89653 -99.73483  1.000 30.30246 ? 51  HIS A ND1 1 
ATOM   386  C CD2 . HIS A 1 51  ? -25.57049  -20.38642 -101.43591 1.000 31.19967 ? 51  HIS A CD2 1 
ATOM   387  C CE1 . HIS A 1 51  ? -24.52835  -19.59674 -99.67567  1.000 27.38247 ? 51  HIS A CE1 1 
ATOM   388  N NE2 . HIS A 1 51  ? -25.29601  -19.26161 -100.69661 1.000 36.55310 ? 51  HIS A NE2 1 
ATOM   389  N N   . LEU A 1 52  ? -23.05106  -25.50550 -102.64737 1.000 24.37853 ? 52  LEU A N   1 
ATOM   390  C CA  . LEU A 1 52  ? -22.82614  -26.94576 -102.71357 1.000 23.35533 ? 52  LEU A CA  1 
ATOM   391  C C   . LEU A 1 52  ? -21.35860  -27.31771 -102.88833 1.000 23.15925 ? 52  LEU A C   1 
ATOM   392  O O   . LEU A 1 52  ? -20.88038  -28.21797 -102.19992 1.000 29.31689 ? 52  LEU A O   1 
ATOM   393  C CB  . LEU A 1 52  ? -23.65463  -27.55585 -103.85806 1.000 19.73839 ? 52  LEU A CB  1 
ATOM   394  C CG  . LEU A 1 52  ? -25.18079  -27.51494 -103.64453 1.000 23.95493 ? 52  LEU A CG  1 
ATOM   395  C CD1 . LEU A 1 52  ? -25.92701  -28.07798 -104.83548 1.000 21.54465 ? 52  LEU A CD1 1 
ATOM   396  C CD2 . LEU A 1 52  ? -25.58811  -28.24690 -102.38858 1.000 20.45694 ? 52  LEU A CD2 1 
ATOM   397  N N   . GLN A 1 53  ? -20.61408  -26.66270 -103.78645 1.000 24.38531 ? 53  GLN A N   1 
ATOM   398  C CA  . GLN A 1 53  ? -19.17880  -26.91827 -103.95973 1.000 22.45797 ? 53  GLN A CA  1 
ATOM   399  C C   . GLN A 1 53  ? -18.39403  -25.60598 -103.86706 1.000 22.80941 ? 53  GLN A C   1 
ATOM   400  O O   . GLN A 1 53  ? -17.91564  -25.07741 -104.87527 1.000 24.00776 ? 53  GLN A O   1 
ATOM   401  C CB  . GLN A 1 53  ? -18.89680  -27.63978 -105.28094 1.000 21.74315 ? 53  GLN A CB  1 
ATOM   402  C CG  . GLN A 1 53  ? -17.61418  -28.47765 -105.23191 1.000 25.25688 ? 53  GLN A CG  1 
ATOM   403  C CD  . GLN A 1 53  ? -17.18597  -29.05690 -106.57461 1.000 30.94371 ? 53  GLN A CD  1 
ATOM   404  O OE1 . GLN A 1 53  ? -16.08961  -29.60988 -106.69086 1.000 31.58288 ? 53  GLN A OE1 1 
ATOM   405  N NE2 . GLN A 1 53  ? -18.04096  -28.93669 -107.59242 1.000 28.13859 ? 53  GLN A NE2 1 
ATOM   406  N N   . PRO A 1 54  ? -18.24379  -25.05247 -102.65816 1.000 21.99359 ? 54  PRO A N   1 
ATOM   407  C CA  . PRO A 1 54  ? -17.55535  -23.75653 -102.52740 1.000 25.16121 ? 54  PRO A CA  1 
ATOM   408  C C   . PRO A 1 54  ? -16.09196  -23.80993 -102.91460 1.000 30.95217 ? 54  PRO A C   1 
ATOM   409  O O   . PRO A 1 54  ? -15.52684  -22.77534 -103.29104 1.000 28.80395 ? 54  PRO A O   1 
ATOM   410  C CB  . PRO A 1 54  ? -17.72507  -23.42115 -101.03907 1.000 22.28985 ? 54  PRO A CB  1 
ATOM   411  C CG  . PRO A 1 54  ? -17.87817  -24.74249 -100.38493 1.000 19.16879 ? 54  PRO A CG  1 
ATOM   412  C CD  . PRO A 1 54  ? -18.64727  -25.59076 -101.35169 1.000 23.22172 ? 54  PRO A CD  1 
ATOM   413  N N   . GLU A 1 55  ? -15.46185  -24.98292 -102.80415 1.000 29.89153 ? 55  GLU A N   1 
ATOM   414  C CA  . GLU A 1 55  ? -14.10778  -25.24683 -103.27626 1.000 26.68404 ? 55  GLU A CA  1 
ATOM   415  C C   . GLU A 1 55  ? -14.13435  -26.58269 -104.00216 1.000 27.50643 ? 55  GLU A C   1 
ATOM   416  O O   . GLU A 1 55  ? -14.97253  -27.43852 -103.70247 1.000 34.46905 ? 55  GLU A O   1 
ATOM   417  C CB  . GLU A 1 55  ? -13.09907  -25.28197 -102.10622 1.000 28.74565 ? 55  GLU A CB  1 
ATOM   418  C CG  . GLU A 1 55  ? -13.13364  -24.02503 -101.21553 1.000 35.45430 ? 55  GLU A CG  1 
ATOM   419  C CD  . GLU A 1 55  ? -12.41384  -24.18549 -99.86391  1.000 47.34024 ? 55  GLU A CD  1 
ATOM   420  O OE1 . GLU A 1 55  ? -11.55056  -25.08582 -99.73088  1.000 47.65734 ? 55  GLU A OE1 1 
ATOM   421  O OE2 . GLU A 1 55  ? -12.69931  -23.38708 -98.93623  1.000 46.34809 ? 55  GLU A OE2 1 
ATOM   422  N N   . GLU A 1 56  ? -13.22975  -26.76430 -104.96245 1.000 25.48936 ? 56  GLU A N   1 
ATOM   423  C CA  . GLU A 1 56  ? -13.25334  -27.99212 -105.75106 1.000 29.18266 ? 56  GLU A CA  1 
ATOM   424  C C   . GLU A 1 56  ? -13.06730  -29.20795 -104.85410 1.000 31.67145 ? 56  GLU A C   1 
ATOM   425  O O   . GLU A 1 56  ? -12.08630  -29.29425 -104.11209 1.000 30.68903 ? 56  GLU A O   1 
ATOM   426  C CB  . GLU A 1 56  ? -12.17372  -27.96540 -106.82030 1.000 31.66089 ? 56  GLU A CB  1 
ATOM   427  C CG  . GLU A 1 56  ? -12.24909  -29.15402 -107.74782 1.000 27.26224 ? 56  GLU A CG  1 
ATOM   428  C CD  . GLU A 1 56  ? -11.39520  -28.96446 -108.98921 1.000 34.29204 ? 56  GLU A CD  1 
ATOM   429  O OE1 . GLU A 1 56  ? -10.49803  -28.09034 -108.95570 1.000 31.21677 ? 56  GLU A OE1 1 
ATOM   430  O OE2 . GLU A 1 56  ? -11.61959  -29.68852 -109.98800 1.000 31.65748 ? 56  GLU A OE2 1 
ATOM   431  N N   . GLY A 1 57  ? -14.01561  -30.14380 -104.91783 1.000 27.62690 ? 57  GLY A N   1 
ATOM   432  C CA  . GLY A 1 57  ? -13.94614  -31.35116 -104.12814 1.000 29.04063 ? 57  GLY A CA  1 
ATOM   433  C C   . GLY A 1 57  ? -14.46555  -31.21633 -102.71657 1.000 28.99148 ? 57  GLY A C   1 
ATOM   434  O O   . GLY A 1 57  ? -14.55989  -32.22590 -102.00740 1.000 25.34311 ? 57  GLY A O   1 
ATOM   435  N N   . LYS A 1 58  ? -14.79224  -30.00828 -102.27686 1.000 25.52802 ? 58  LYS A N   1 
ATOM   436  C CA  . LYS A 1 58  ? -15.42577  -29.79161 -100.98189 1.000 28.68603 ? 58  LYS A CA  1 
ATOM   437  C C   . LYS A 1 58  ? -16.91732  -29.55072 -101.21284 1.000 28.95566 ? 58  LYS A C   1 
ATOM   438  O O   . LYS A 1 58  ? -17.31645  -28.49371 -101.72283 1.000 26.90305 ? 58  LYS A O   1 
ATOM   439  C CB  . LYS A 1 58  ? -14.78304  -28.61773 -100.25189 1.000 29.61328 ? 58  LYS A CB  1 
ATOM   440  C CG  . LYS A 1 58  ? -15.44071  -28.29896 -98.90750  1.000 30.09686 ? 58  LYS A CG  1 
ATOM   441  C CD  . LYS A 1 58  ? -14.72936  -27.13319 -98.22337  1.000 32.51836 ? 58  LYS A CD  1 
ATOM   442  C CE  . LYS A 1 58  ? -15.30159  -26.88631 -96.83434  1.000 38.25074 ? 58  LYS A CE  1 
ATOM   443  N NZ  . LYS A 1 58  ? -14.81697  -25.60867 -96.23857  1.000 30.28427 ? 58  LYS A NZ  1 
ATOM   444  N N   . PHE A 1 59  ? -17.73978  -30.53176 -100.85470 1.000 26.52299 ? 59  PHE A N   1 
ATOM   445  C CA  . PHE A 1 59  ? -19.18433  -30.43828 -101.04319 1.000 22.48429 ? 59  PHE A CA  1 
ATOM   446  C C   . PHE A 1 59  ? -19.85290  -30.17650 -99.70838  1.000 25.50423 ? 59  PHE A C   1 
ATOM   447  O O   . PHE A 1 59  ? -19.55014  -30.85184 -98.71427  1.000 20.82701 ? 59  PHE A O   1 
ATOM   448  C CB  . PHE A 1 59  ? -19.74785  -31.70216 -101.69144 1.000 21.82912 ? 59  PHE A CB  1 
ATOM   449  C CG  . PHE A 1 59  ? -19.35619  -31.85027 -103.12284 1.000 25.41491 ? 59  PHE A CG  1 
ATOM   450  C CD1 . PHE A 1 59  ? -18.17590  -32.49356 -103.47476 1.000 18.27027 ? 59  PHE A CD1 1 
ATOM   451  C CD2 . PHE A 1 59  ? -20.14692  -31.31160 -104.12229 1.000 26.13327 ? 59  PHE A CD2 1 
ATOM   452  C CE1 . PHE A 1 59  ? -17.81815  -32.61942 -104.80224 1.000 25.59032 ? 59  PHE A CE1 1 
ATOM   453  C CE2 . PHE A 1 59  ? -19.78721  -31.43903 -105.46158 1.000 26.29923 ? 59  PHE A CE2 1 
ATOM   454  C CZ  . PHE A 1 59  ? -18.62384  -32.08432 -105.80215 1.000 22.85880 ? 59  PHE A CZ  1 
ATOM   455  N N   . THR A 1 60  ? -20.74291  -29.18183 -99.68418  1.000 17.68993 ? 60  THR A N   1 
ATOM   456  C CA  . THR A 1 60  ? -21.40680  -28.76332 -98.44940  1.000 21.59376 ? 60  THR A CA  1 
ATOM   457  C C   . THR A 1 60  ? -22.91464  -28.94389 -98.61085  1.000 28.40127 ? 60  THR A C   1 
ATOM   458  O O   . THR A 1 60  ? -23.64037  -27.99160 -98.90126  1.000 24.36630 ? 60  THR A O   1 
ATOM   459  C CB  . THR A 1 60  ? -21.02113  -27.33210 -98.09574  1.000 25.96541 ? 60  THR A CB  1 
ATOM   460  O OG1 . THR A 1 60  ? -21.25945  -26.47453 -99.21586  1.000 24.83904 ? 60  THR A OG1 1 
ATOM   461  C CG2 . THR A 1 60  ? -19.53891  -27.27001 -97.73545  1.000 22.63103 ? 60  THR A CG2 1 
ATOM   462  N N   . PHE A 1 61  ? -23.38134  -30.17671 -98.40081  1.000 18.58884 ? 61  PHE A N   1 
ATOM   463  C CA  . PHE A 1 61  ? -24.77516  -30.53327 -98.61627  1.000 22.44078 ? 61  PHE A CA  1 
ATOM   464  C C   . PHE A 1 61  ? -25.63160  -30.34919 -97.38470  1.000 27.81725 ? 61  PHE A C   1 
ATOM   465  O O   . PHE A 1 61  ? -26.82026  -30.68408 -97.43236  1.000 26.96748 ? 61  PHE A O   1 
ATOM   466  C CB  . PHE A 1 61  ? -24.91029  -31.98971 -99.07496  1.000 16.16845 ? 61  PHE A CB  1 
ATOM   467  C CG  . PHE A 1 61  ? -24.39731  -32.24507 -100.46814 1.000 27.04232 ? 61  PHE A CG  1 
ATOM   468  C CD1 . PHE A 1 61  ? -25.02758  -31.68197 -101.57513 1.000 23.18285 ? 61  PHE A CD1 1 
ATOM   469  C CD2 . PHE A 1 61  ? -23.28316  -33.05630 -100.67440 1.000 21.73612 ? 61  PHE A CD2 1 
ATOM   470  C CE1 . PHE A 1 61  ? -24.56430  -31.93112 -102.86287 1.000 21.71307 ? 61  PHE A CE1 1 
ATOM   471  C CE2 . PHE A 1 61  ? -22.81660  -33.31506 -101.95421 1.000 21.51301 ? 61  PHE A CE2 1 
ATOM   472  C CZ  . PHE A 1 61  ? -23.45085  -32.75300 -103.05606 1.000 21.17090 ? 61  PHE A CZ  1 
ATOM   473  N N   . GLN A 1 62  ? -25.06793  -29.83309 -96.28810  1.000 24.13607 ? 62  GLN A N   1 
ATOM   474  C CA  . GLN A 1 62  ? -25.77726  -29.90774 -95.01351  1.000 24.01309 ? 62  GLN A CA  1 
ATOM   475  C C   . GLN A 1 62  ? -27.10402  -29.15164 -95.07588  1.000 25.90793 ? 62  GLN A C   1 
ATOM   476  O O   . GLN A 1 62  ? -28.15678  -29.71551 -94.75962  1.000 26.87312 ? 62  GLN A O   1 
ATOM   477  C CB  . GLN A 1 62  ? -24.88973  -29.39624 -93.87643  1.000 24.66714 ? 62  GLN A CB  1 
ATOM   478  C CG  . GLN A 1 62  ? -23.52878  -30.13702 -93.73679  1.000 22.77886 ? 62  GLN A CG  1 
ATOM   479  C CD  . GLN A 1 62  ? -22.39282  -29.32944 -94.34545  1.000 32.97652 ? 62  GLN A CD  1 
ATOM   480  O OE1 . GLN A 1 62  ? -22.43861  -28.96811 -95.53338  1.000 23.65492 ? 62  GLN A OE1 1 
ATOM   481  N NE2 . GLN A 1 62  ? -21.37891  -29.01195 -93.53037  1.000 35.09549 ? 62  GLN A NE2 1 
ATOM   482  N N   . GLU A 1 63  ? -27.08164  -27.88739 -95.52842  1.000 27.79196 ? 63  GLU A N   1 
ATOM   483  C CA  . GLU A 1 63  ? -28.31172  -27.08579 -95.57698  1.000 28.17307 ? 63  GLU A CA  1 
ATOM   484  C C   . GLU A 1 63  ? -29.30290  -27.60926 -96.62306  1.000 26.99379 ? 63  GLU A C   1 
ATOM   485  O O   . GLU A 1 63  ? -30.50779  -27.67439 -96.35945  1.000 31.59290 ? 63  GLU A O   1 
ATOM   486  C CB  . GLU A 1 63  ? -27.97272  -25.61764 -95.84821  1.000 30.64410 ? 63  GLU A CB  1 
ATOM   487  C CG  . GLU A 1 63  ? -26.85818  -25.06086 -94.95667  1.000 38.68051 ? 63  GLU A CG  1 
ATOM   488  C CD  . GLU A 1 63  ? -27.34658  -24.60338 -93.58399  1.000 52.19038 ? 63  GLU A CD  1 
ATOM   489  O OE1 . GLU A 1 63  ? -28.09148  -25.35548 -92.91012  1.000 47.67610 ? 63  GLU A OE1 1 
ATOM   490  O OE2 . GLU A 1 63  ? -26.96162  -23.48791 -93.16733  1.000 64.36652 ? 63  GLU A OE2 1 
ATOM   491  N N   . ALA A 1 64  ? -28.82081  -27.97797 -97.81672  1.000 26.47053 ? 64  ALA A N   1 
ATOM   492  C CA  . ALA A 1 64  ? -29.69191  -28.58457 -98.82345  1.000 22.31861 ? 64  ALA A CA  1 
ATOM   493  C C   . ALA A 1 64  ? -30.32611  -29.87597 -98.31579  1.000 24.54464 ? 64  ALA A C   1 
ATOM   494  O O   . ALA A 1 64  ? -31.49253  -30.16774 -98.61852  1.000 24.00879 ? 64  ALA A O   1 
ATOM   495  C CB  . ALA A 1 64  ? -28.90075  -28.85009 -100.10646 1.000 24.17018 ? 64  ALA A CB  1 
ATOM   496  N N   . ASP A 1 65  ? -29.56273  -30.67762 -97.56318  1.000 24.48876 ? 65  ASP A N   1 
ATOM   497  C CA  . ASP A 1 65  ? -30.10937  -31.88123 -96.93629  1.000 21.42681 ? 65  ASP A CA  1 
ATOM   498  C C   . ASP A 1 65  ? -31.25771  -31.54437 -95.99323  1.000 22.73502 ? 65  ASP A C   1 
ATOM   499  O O   . ASP A 1 65  ? -32.25899  -32.26415 -95.94060  1.000 25.01719 ? 65  ASP A O   1 
ATOM   500  C CB  . ASP A 1 65  ? -29.01461  -32.61174 -96.15233  1.000 28.95037 ? 65  ASP A CB  1 
ATOM   501  C CG  . ASP A 1 65  ? -28.04659  -33.37791 -97.03445  1.000 30.85791 ? 65  ASP A CG  1 
ATOM   502  O OD1 . ASP A 1 65  ? -28.31845  -33.61670 -98.24305  1.000 23.43322 ? 65  ASP A OD1 1 
ATOM   503  O OD2 . ASP A 1 65  ? -27.00682  -33.77444 -96.47937  1.000 31.44264 ? 65  ASP A OD2 1 
ATOM   504  N N   . ARG A 1 66  ? -31.11351  -30.47147 -95.20794  1.000 23.86068 ? 66  ARG A N   1 
ATOM   505  C CA  . ARG A 1 66  ? -32.16680  -30.10012 -94.27138  1.000 24.96292 ? 66  ARG A CA  1 
ATOM   506  C C   . ARG A 1 66  ? -33.45090  -29.71412 -95.01174  1.000 28.43940 ? 66  ARG A C   1 
ATOM   507  O O   . ARG A 1 66  ? -34.55720  -30.08133 -94.59805  1.000 33.20322 ? 66  ARG A O   1 
ATOM   508  C CB  . ARG A 1 66  ? -31.66415  -28.96733 -93.37938  1.000 24.65453 ? 66  ARG A CB  1 
ATOM   509  C CG  . ARG A 1 66  ? -32.68660  -28.37558 -92.39814  1.000 45.15652 ? 66  ARG A CG  1 
ATOM   510  C CD  . ARG A 1 66  ? -33.55008  -29.44873 -91.74390  1.000 46.65296 ? 66  ARG A CD  1 
ATOM   511  N NE  . ARG A 1 66  ? -34.82811  -28.93074 -91.27380  1.000 40.05243 ? 66  ARG A NE  1 
ATOM   512  C CZ  . ARG A 1 66  ? -35.89386  -29.68987 -91.03336  1.000 48.78299 ? 66  ARG A CZ  1 
ATOM   513  N NH1 . ARG A 1 66  ? -35.84319  -31.00397 -91.24665  1.000 44.08652 ? 66  ARG A NH1 1 
ATOM   514  N NH2 . ARG A 1 66  ? -37.01441  -29.13197 -90.58603  1.000 49.06904 ? 66  ARG A NH2 1 
ATOM   515  N N   . ILE A 1 67  ? -33.31466  -29.00734 -96.12747  1.000 29.80569 ? 67  ILE A N   1 
ATOM   516  C CA  . ILE A 1 67  ? -34.46640  -28.61674 -96.92636  1.000 29.30113 ? 67  ILE A CA  1 
ATOM   517  C C   . ILE A 1 67  ? -35.14222  -29.84441 -97.52075  1.000 26.05295 ? 67  ILE A C   1 
ATOM   518  O O   . ILE A 1 67  ? -36.36147  -30.01631 -97.40704  1.000 25.39455 ? 67  ILE A O   1 
ATOM   519  C CB  . ILE A 1 67  ? -34.01392  -27.61783 -98.00238  1.000 21.32311 ? 67  ILE A CB  1 
ATOM   520  C CG1 . ILE A 1 67  ? -33.47750  -26.35668 -97.30369  1.000 22.07402 ? 67  ILE A CG1 1 
ATOM   521  C CG2 . ILE A 1 67  ? -35.13615  -27.33121 -99.00653  1.000 26.86277 ? 67  ILE A CG2 1 
ATOM   522  C CD1 . ILE A 1 67  ? -32.81781  -25.34518 -98.22103  1.000 23.53348 ? 67  ILE A CD1 1 
ATOM   523  N N   . VAL A 1 68  ? -34.35779  -30.72518 -98.14536  1.000 25.13291 ? 68  VAL A N   1 
ATOM   524  C CA  . VAL A 1 68  ? -34.90549  -31.96194 -98.70099  1.000 21.67819 ? 68  VAL A CA  1 
ATOM   525  C C   . VAL A 1 68  ? -35.53751  -32.81243 -97.60069  1.000 27.45098 ? 68  VAL A C   1 
ATOM   526  O O   . VAL A 1 68  ? -36.61147  -33.40166 -97.79498  1.000 30.31398 ? 68  VAL A O   1 
ATOM   527  C CB  . VAL A 1 68  ? -33.80758  -32.72990 -99.47152  1.000 26.77649 ? 68  VAL A CB  1 
ATOM   528  C CG1 . VAL A 1 68  ? -34.27196  -34.09965 -99.90491  1.000 16.11254 ? 68  VAL A CG1 1 
ATOM   529  C CG2 . VAL A 1 68  ? -33.39032  -31.95774 -100.68942 1.000 22.29737 ? 68  VAL A CG2 1 
ATOM   530  N N   . ASP A 1 69  ? -34.89974  -32.87762 -96.42160  1.000 24.51204 ? 69  ASP A N   1 
ATOM   531  C CA  . ASP A 1 69  ? -35.45360  -33.68386 -95.33162  1.000 30.16219 ? 69  ASP A CA  1 
ATOM   532  C C   . ASP A 1 69  ? -36.81939  -33.15358 -94.90177  1.000 31.64395 ? 69  ASP A C   1 
ATOM   533  O O   . ASP A 1 69  ? -37.77653  -33.92286 -94.73866  1.000 30.16133 ? 69  ASP A O   1 
ATOM   534  C CB  . ASP A 1 69  ? -34.49602  -33.72174 -94.13127  1.000 31.80575 ? 69  ASP A CB  1 
ATOM   535  C CG  . ASP A 1 69  ? -33.30628  -34.67242 -94.33615  1.000 39.85233 ? 69  ASP A CG  1 
ATOM   536  O OD1 . ASP A 1 69  ? -33.36643  -35.54223 -95.23028  1.000 48.24007 ? 69  ASP A OD1 1 
ATOM   537  O OD2 . ASP A 1 69  ? -32.30508  -34.55568 -93.58617  1.000 48.33652 ? 69  ASP A OD2 1 
ATOM   538  N N   . PHE A 1 70  ? -36.91996  -31.83809 -94.69355  1.000 27.55717 ? 70  PHE A N   1 
ATOM   539  C CA  . PHE A 1 70  ? -38.20012  -31.23462 -94.33985  1.000 31.32432 ? 70  PHE A CA  1 
ATOM   540  C C   . PHE A 1 70  ? -39.26827  -31.58378 -95.37143  1.000 31.33677 ? 70  PHE A C   1 
ATOM   541  O O   . PHE A 1 70  ? -40.34035  -32.09779 -95.02307  1.000 29.44080 ? 70  PHE A O   1 
ATOM   542  C CB  . PHE A 1 70  ? -38.03948  -29.71468 -94.19994  1.000 30.94942 ? 70  PHE A CB  1 
ATOM   543  C CG  . PHE A 1 70  ? -39.33500  -28.98125 -93.94950  1.000 36.55865 ? 70  PHE A CG  1 
ATOM   544  C CD1 . PHE A 1 70  ? -39.86963  -28.90179 -92.67008  1.000 33.99705 ? 70  PHE A CD1 1 
ATOM   545  C CD2 . PHE A 1 70  ? -40.01834  -28.37746 -94.99409  1.000 35.91373 ? 70  PHE A CD2 1 
ATOM   546  C CE1 . PHE A 1 70  ? -41.04774  -28.23244 -92.43098  1.000 36.56622 ? 70  PHE A CE1 1 
ATOM   547  C CE2 . PHE A 1 70  ? -41.21856  -27.70667 -94.77095  1.000 33.98247 ? 70  PHE A CE2 1 
ATOM   548  C CZ  . PHE A 1 70  ? -41.73322  -27.63249 -93.48752  1.000 42.13681 ? 70  PHE A CZ  1 
ATOM   549  N N   . ALA A 1 71  ? -38.97115  -31.36181 -96.65869  1.000 30.53778 ? 71  ALA A N   1 
ATOM   550  C CA  . ALA A 1 71  ? -39.97997  -31.59070 -97.69170  1.000 28.83044 ? 71  ALA A CA  1 
ATOM   551  C C   . ALA A 1 71  ? -40.43721  -33.04042 -97.71521  1.000 30.02632 ? 71  ALA A C   1 
ATOM   552  O O   . ALA A 1 71  ? -41.63990  -33.32193 -97.83978  1.000 30.29394 ? 71  ALA A O   1 
ATOM   553  C CB  . ALA A 1 71  ? -39.44687  -31.18131 -99.06013  1.000 20.63826 ? 71  ALA A CB  1 
ATOM   554  N N   . CYS A 1 72  ? -39.49614  -33.97734 -97.59470  1.000 36.17526 ? 72  CYS A N   1 
ATOM   555  C CA  . CYS A 1 72  ? -39.85473  -35.38873 -97.67861  1.000 31.31397 ? 72  CYS A CA  1 
ATOM   556  C C   . CYS A 1 72  ? -40.62655  -35.82524 -96.43841  1.000 33.81274 ? 72  CYS A C   1 
ATOM   557  O O   . CYS A 1 72  ? -41.55377  -36.63357 -96.53032  1.000 39.09524 ? 72  CYS A O   1 
ATOM   558  C CB  . CYS A 1 72  ? -38.60262  -36.24401 -97.88379  1.000 37.81090 ? 72  CYS A CB  1 
ATOM   559  S SG  . CYS A 1 72  ? -37.92352  -36.24597 -99.58566  1.000 51.26711 ? 72  CYS A SG  1 
ATOM   560  N N   . SER A 1 73  ? -40.30117  -35.25967 -95.27540  1.000 31.43536 ? 73  SER A N   1 
ATOM   561  C CA  . SER A 1 73  ? -41.04084  -35.62502 -94.06698  1.000 30.36273 ? 73  SER A CA  1 
ATOM   562  C C   . SER A 1 73  ? -42.43663  -35.00444 -94.02598  1.000 35.49730 ? 73  SER A C   1 
ATOM   563  O O   . SER A 1 73  ? -43.22284  -35.33791 -93.13701  1.000 33.37678 ? 73  SER A O   1 
ATOM   564  C CB  . SER A 1 73  ? -40.24902  -35.22988 -92.80325  1.000 30.84817 ? 73  SER A CB  1 
ATOM   565  O OG  . SER A 1 73  ? -40.41015  -33.86320 -92.46563  1.000 38.08103 ? 73  SER A OG  1 
ATOM   566  N N   . HIS A 1 74  ? -42.77254  -34.12240 -94.96992  1.000 37.00349 ? 74  HIS A N   1 
ATOM   567  C CA  . HIS A 1 74  ? -44.10019  -33.52473 -95.04830  1.000 30.53961 ? 74  HIS A CA  1 
ATOM   568  C C   . HIS A 1 74  ? -44.75579  -33.74480 -96.40553  1.000 34.53375 ? 74  HIS A C   1 
ATOM   569  O O   . HIS A 1 74  ? -45.65319  -32.99287 -96.77688  1.000 38.03601 ? 74  HIS A O   1 
ATOM   570  C CB  . HIS A 1 74  ? -44.03769  -32.03266 -94.73555  1.000 29.36397 ? 74  HIS A CB  1 
ATOM   571  C CG  . HIS A 1 74  ? -43.74149  -31.74982 -93.30361  1.000 33.80441 ? 74  HIS A CG  1 
ATOM   572  N ND1 . HIS A 1 74  ? -42.48728  -31.38138 -92.86720  1.000 37.32902 ? 74  HIS A ND1 1 
ATOM   573  C CD2 . HIS A 1 74  ? -44.52730  -31.79111 -92.20406  1.000 29.26307 ? 74  HIS A CD2 1 
ATOM   574  C CE1 . HIS A 1 74  ? -42.51115  -31.21032 -91.55839  1.000 39.90535 ? 74  HIS A CE1 1 
ATOM   575  N NE2 . HIS A 1 74  ? -43.73825  -31.44780 -91.13275  1.000 45.01660 ? 74  HIS A NE2 1 
ATOM   576  N N   . ARG A 1 75  ? -44.30760  -34.74960 -97.16522  1.000 35.36802 ? 75  ARG A N   1 
ATOM   577  C CA  . ARG A 1 75  ? -44.93918  -35.13476 -98.42487  1.000 33.79547 ? 75  ARG A CA  1 
ATOM   578  C C   . ARG A 1 75  ? -44.95957  -33.97511 -99.42701  1.000 37.47739 ? 75  ARG A C   1 
ATOM   579  O O   . ARG A 1 75  ? -45.94396  -33.75133 -100.13518 1.000 33.95248 ? 75  ARG A O   1 
ATOM   580  C CB  . ARG A 1 75  ? -46.35391  -35.66817 -98.16859  1.000 41.92418 ? 75  ARG A CB  1 
ATOM   581  C CG  . ARG A 1 75  ? -46.39283  -37.10888 -97.61763  1.000 60.95053 ? 75  ARG A CG  1 
ATOM   582  C CD  . ARG A 1 75  ? -47.75068  -37.44593 -96.93511  1.000 62.62550 ? 75  ARG A CD  1 
ATOM   583  N NE  . ARG A 1 75  ? -48.40509  -36.28400 -96.29780  1.000 69.81487 ? 75  ARG A NE  1 
ATOM   584  C CZ  . ARG A 1 75  ? -49.63663  -35.83663 -96.58349  1.000 72.65937 ? 75  ARG A CZ  1 
ATOM   585  N NH1 . ARG A 1 75  ? -50.39499  -36.43505 -97.50764  1.000 73.12185 ? 75  ARG A NH1 1 
ATOM   586  N NH2 . ARG A 1 75  ? -50.12804  -34.77681 -95.92612  1.000 78.48354 ? 75  ARG A NH2 1 
ATOM   587  N N   . MET A 1 76  ? -43.87246  -33.20855 -99.47166  1.000 28.70212 ? 76  MET A N   1 
ATOM   588  C CA  . MET A 1 76  ? -43.73752  -32.13603 -100.44114 1.000 28.03644 ? 76  MET A CA  1 
ATOM   589  C C   . MET A 1 76  ? -42.71317  -32.54724 -101.48376 1.000 28.11152 ? 76  MET A C   1 
ATOM   590  O O   . MET A 1 76  ? -41.69247  -33.15690 -101.14973 1.000 31.27187 ? 76  MET A O   1 
ATOM   591  C CB  . MET A 1 76  ? -43.32496  -30.83174 -99.76680  1.000 21.33588 ? 76  MET A CB  1 
ATOM   592  C CG  . MET A 1 76  ? -44.26137  -30.39309 -98.67045  1.000 22.39076 ? 76  MET A CG  1 
ATOM   593  S SD  . MET A 1 76  ? -43.45311  -29.21916 -97.57614  1.000 26.99656 ? 76  MET A SD  1 
ATOM   594  C CE  . MET A 1 76  ? -44.83853  -28.74307 -96.53949  1.000 31.20401 ? 76  MET A CE  1 
ATOM   595  N N   . ALA A 1 77  ? -43.02116  -32.26555 -102.75059 1.000 21.61744 ? 77  ALA A N   1 
ATOM   596  C CA  . ALA A 1 77  ? -42.04529  -32.41854 -103.81672 1.000 25.10242 ? 77  ALA A CA  1 
ATOM   597  C C   . ALA A 1 77  ? -40.96550  -31.33943 -103.68734 1.000 22.49347 ? 77  ALA A C   1 
ATOM   598  O O   . ALA A 1 77  ? -41.11535  -30.35840 -102.94872 1.000 19.57644 ? 77  ALA A O   1 
ATOM   599  C CB  . ALA A 1 77  ? -42.73189  -32.34228 -105.17810 1.000 22.37182 ? 77  ALA A CB  1 
ATOM   600  N N   . VAL A 1 78  ? -39.85627  -31.52539 -104.40563 1.000 22.56443 ? 78  VAL A N   1 
ATOM   601  C CA  . VAL A 1 78  ? -38.73826  -30.58102 -104.37231 1.000 19.11669 ? 78  VAL A CA  1 
ATOM   602  C C   . VAL A 1 78  ? -38.29403  -30.25884 -105.78833 1.000 25.61721 ? 78  VAL A C   1 
ATOM   603  O O   . VAL A 1 78  ? -38.03424  -31.16814 -106.58641 1.000 24.14300 ? 78  VAL A O   1 
ATOM   604  C CB  . VAL A 1 78  ? -37.54056  -31.11908 -103.57327 1.000 23.49365 ? 78  VAL A CB  1 
ATOM   605  C CG1 . VAL A 1 78  ? -36.40750  -30.08584 -103.54887 1.000 16.41304 ? 78  VAL A CG1 1 
ATOM   606  C CG2 . VAL A 1 78  ? -37.96158  -31.50297 -102.17208 1.000 15.33262 ? 78  VAL A CG2 1 
ATOM   607  N N   . ARG A 1 79  ? -38.18987  -28.96510 -106.09245 1.000 22.08423 ? 79  ARG A N   1 
ATOM   608  C CA  . ARG A 1 79  ? -37.49711  -28.51571 -107.28716 1.000 22.31582 ? 79  ARG A CA  1 
ATOM   609  C C   . ARG A 1 79  ? -36.04746  -28.21423 -106.93095 1.000 22.71839 ? 79  ARG A C   1 
ATOM   610  O O   . ARG A 1 79  ? -35.76143  -27.59002 -105.89523 1.000 22.38697 ? 79  ARG A O   1 
ATOM   611  C CB  . ARG A 1 79  ? -38.14794  -27.26476 -107.87956 1.000 23.49852 ? 79  ARG A CB  1 
ATOM   612  C CG  . ARG A 1 79  ? -39.64397  -27.38149 -108.20081 1.000 22.55656 ? 79  ARG A CG  1 
ATOM   613  C CD  . ARG A 1 79  ? -40.15416  -26.14569 -108.98345 1.000 19.22385 ? 79  ARG A CD  1 
ATOM   614  N NE  . ARG A 1 79  ? -39.76589  -26.25066 -110.39107 1.000 19.36533 ? 79  ARG A NE  1 
ATOM   615  C CZ  . ARG A 1 79  ? -38.69449  -25.67254 -110.91482 1.000 17.88234 ? 79  ARG A CZ  1 
ATOM   616  N NH1 . ARG A 1 79  ? -37.90685  -24.90502 -110.15539 1.000 19.78982 ? 79  ARG A NH1 1 
ATOM   617  N NH2 . ARG A 1 79  ? -38.40467  -25.86700 -112.19302 1.000 17.63455 ? 79  ARG A NH2 1 
ATOM   618  N N   . GLY A 1 80  ? -35.13530  -28.63606 -107.80347 1.000 18.73338 ? 80  GLY A N   1 
ATOM   619  C CA  . GLY A 1 80  ? -33.72055  -28.34304 -107.61835 1.000 22.74182 ? 80  GLY A CA  1 
ATOM   620  C C   . GLY A 1 80  ? -33.33831  -27.07982 -108.36163 1.000 20.33809 ? 80  GLY A C   1 
ATOM   621  O O   . GLY A 1 80  ? -33.59372  -26.95730 -109.56090 1.000 20.16640 ? 80  GLY A O   1 
ATOM   622  N N   . HIS A 1 81  ? -32.70761  -26.14684 -107.64513 1.000 21.75614 ? 81  HIS A N   1 
ATOM   623  C CA  . HIS A 1 81  ? -32.33410  -24.83206 -108.16570 1.000 14.66503 ? 81  HIS A CA  1 
ATOM   624  C C   . HIS A 1 81  ? -30.97964  -24.45693 -107.56781 1.000 19.51408 ? 81  HIS A C   1 
ATOM   625  O O   . HIS A 1 81  ? -30.86333  -24.35045 -106.34317 1.000 18.61835 ? 81  HIS A O   1 
ATOM   626  C CB  . HIS A 1 81  ? -33.41875  -23.80187 -107.79275 1.000 14.27545 ? 81  HIS A CB  1 
ATOM   627  C CG  . HIS A 1 81  ? -33.12445  -22.39209 -108.22353 1.000 21.53563 ? 81  HIS A CG  1 
ATOM   628  N ND1 . HIS A 1 81  ? -33.41525  -21.91034 -109.48455 1.000 19.78658 ? 81  HIS A ND1 1 
ATOM   629  C CD2 . HIS A 1 81  ? -32.58503  -21.35034 -107.54420 1.000 25.02617 ? 81  HIS A CD2 1 
ATOM   630  C CE1 . HIS A 1 81  ? -33.04889  -20.64279 -109.56885 1.000 20.36953 ? 81  HIS A CE1 1 
ATOM   631  N NE2 . HIS A 1 81  ? -32.54795  -20.27574 -108.40219 1.000 22.48040 ? 81  HIS A NE2 1 
ATOM   632  N N   . THR A 1 82  ? -29.94383  -24.26020 -108.39352 1.000 20.40143 ? 82  THR A N   1 
ATOM   633  C CA  . THR A 1 82  ? -29.91275  -24.41344 -109.85162 1.000 19.85479 ? 82  THR A CA  1 
ATOM   634  C C   . THR A 1 82  ? -28.47372  -24.84806 -110.18383 1.000 24.64795 ? 82  THR A C   1 
ATOM   635  O O   . THR A 1 82  ? -27.56140  -24.57448 -109.40827 1.000 24.07582 ? 82  THR A O   1 
ATOM   636  C CB  . THR A 1 82  ? -30.28118  -23.09554 -110.59412 1.000 18.67650 ? 82  THR A CB  1 
ATOM   637  O OG1 . THR A 1 82  ? -30.18085  -23.28638 -112.00210 1.000 25.07981 ? 82  THR A OG1 1 
ATOM   638  C CG2 . THR A 1 82  ? -29.33481  -21.97089 -110.21142 1.000 17.21053 ? 82  THR A CG2 1 
ATOM   639  N N   . LEU A 1 83  ? -28.24879  -25.49586 -111.32855 1.000 28.88637 ? 83  LEU A N   1 
ATOM   640  C CA  . LEU A 1 83  ? -26.94410  -26.10819 -111.59460 1.000 22.61709 ? 83  LEU A CA  1 
ATOM   641  C C   . LEU A 1 83  ? -25.95321  -25.16308 -112.27353 1.000 28.27045 ? 83  LEU A C   1 
ATOM   642  O O   . LEU A 1 83  ? -24.82558  -24.99328 -111.79430 1.000 24.46515 ? 83  LEU A O   1 
ATOM   643  C CB  . LEU A 1 83  ? -27.12540  -27.36622 -112.45300 1.000 25.92731 ? 83  LEU A CB  1 
ATOM   644  C CG  . LEU A 1 83  ? -27.92218  -28.47958 -111.77924 1.000 21.97230 ? 83  LEU A CG  1 
ATOM   645  C CD1 . LEU A 1 83  ? -28.20015  -29.61214 -112.75160 1.000 19.88161 ? 83  LEU A CD1 1 
ATOM   646  C CD2 . LEU A 1 83  ? -27.16724  -28.97891 -110.57523 1.000 20.37544 ? 83  LEU A CD2 1 
ATOM   647  N N   . VAL A 1 84  ? -26.32714  -24.58294 -113.41121 1.000 25.45880 ? 84  VAL A N   1 
ATOM   648  C CA  . VAL A 1 84  ? -25.41733  -23.77114 -114.21757 1.000 29.47976 ? 84  VAL A CA  1 
ATOM   649  C C   . VAL A 1 84  ? -26.01412  -22.37218 -114.35572 1.000 30.03705 ? 84  VAL A C   1 
ATOM   650  O O   . VAL A 1 84  ? -27.09736  -22.19858 -114.93440 1.000 30.58094 ? 84  VAL A O   1 
ATOM   651  C CB  . VAL A 1 84  ? -25.14545  -24.42272 -115.58605 1.000 32.88154 ? 84  VAL A CB  1 
ATOM   652  C CG1 . VAL A 1 84  ? -24.34578  -23.50047 -116.50164 1.000 27.29195 ? 84  VAL A CG1 1 
ATOM   653  C CG2 . VAL A 1 84  ? -24.37155  -25.73721 -115.38874 1.000 24.91768 ? 84  VAL A CG2 1 
ATOM   654  N N   . TRP A 1 85  ? -25.30701  -21.37790 -113.82274 1.000 31.13097 ? 85  TRP A N   1 
ATOM   655  C CA  . TRP A 1 85  ? -25.81245  -20.01425 -113.73157 1.000 29.33296 ? 85  TRP A CA  1 
ATOM   656  C C   . TRP A 1 85  ? -24.61794  -19.07959 -113.73689 1.000 30.25629 ? 85  TRP A C   1 
ATOM   657  O O   . TRP A 1 85  ? -23.55558  -19.42260 -113.21421 1.000 31.41894 ? 85  TRP A O   1 
ATOM   658  C CB  . TRP A 1 85  ? -26.63998  -19.81944 -112.44534 1.000 26.70202 ? 85  TRP A CB  1 
ATOM   659  C CG  . TRP A 1 85  ? -27.37009  -18.49776 -112.29851 1.000 27.55620 ? 85  TRP A CG  1 
ATOM   660  C CD1 . TRP A 1 85  ? -27.77327  -17.66330 -113.29792 1.000 26.58751 ? 85  TRP A CD1 1 
ATOM   661  C CD2 . TRP A 1 85  ? -27.79498  -17.87890 -111.06798 1.000 29.40436 ? 85  TRP A CD2 1 
ATOM   662  N NE1 . TRP A 1 85  ? -28.42487  -16.56585 -112.77177 1.000 25.74113 ? 85  TRP A NE1 1 
ATOM   663  C CE2 . TRP A 1 85  ? -28.45248  -16.67335 -111.40845 1.000 29.67074 ? 85  TRP A CE2 1 
ATOM   664  C CE3 . TRP A 1 85  ? -27.68914  -18.22883 -109.72029 1.000 24.12771 ? 85  TRP A CE3 1 
ATOM   665  C CZ2 . TRP A 1 85  ? -28.98938  -15.81027 -110.44761 1.000 30.44561 ? 85  TRP A CZ2 1 
ATOM   666  C CZ3 . TRP A 1 85  ? -28.23341  -17.37218 -108.76223 1.000 25.82334 ? 85  TRP A CZ3 1 
ATOM   667  C CH2 . TRP A 1 85  ? -28.87712  -16.18016 -109.13318 1.000 25.08494 ? 85  TRP A CH2 1 
ATOM   668  N N   . HIS A 1 86  ? -24.79917  -17.88883 -114.31313 1.000 30.60364 ? 86  HIS A N   1 
ATOM   669  C CA  . HIS A 1 86  ? -23.71734  -16.90663 -114.31044 1.000 30.19656 ? 86  HIS A CA  1 
ATOM   670  C C   . HIS A 1 86  ? -23.50686  -16.26535 -112.94301 1.000 32.90823 ? 86  HIS A C   1 
ATOM   671  O O   . HIS A 1 86  ? -22.49864  -15.57933 -112.75463 1.000 31.78539 ? 86  HIS A O   1 
ATOM   672  C CB  . HIS A 1 86  ? -23.96024  -15.82366 -115.38394 1.000 27.29123 ? 86  HIS A CB  1 
ATOM   673  C CG  . HIS A 1 86  ? -25.14333  -14.93975 -115.11250 1.000 31.44143 ? 86  HIS A CG  1 
ATOM   674  N ND1 . HIS A 1 86  ? -26.44092  -15.31786 -115.39246 1.000 29.77029 ? 86  HIS A ND1 1 
ATOM   675  C CD2 . HIS A 1 86  ? -25.22171  -13.69194 -114.59140 1.000 25.55846 ? 86  HIS A CD2 1 
ATOM   676  C CE1 . HIS A 1 86  ? -27.26836  -14.34744 -115.04213 1.000 27.93575 ? 86  HIS A CE1 1 
ATOM   677  N NE2 . HIS A 1 86  ? -26.55387  -13.34707 -114.56025 1.000 31.35352 ? 86  HIS A NE2 1 
ATOM   678  N N   . ASN A 1 87  ? -24.40882  -16.46896 -111.98641 1.000 31.57191 ? 87  ASN A N   1 
ATOM   679  C CA  . ASN A 1 87  ? -24.23613  -15.91940 -110.64861 1.000 29.66074 ? 87  ASN A CA  1 
ATOM   680  C C   . ASN A 1 87  ? -23.97626  -17.03228 -109.63974 1.000 30.79471 ? 87  ASN A C   1 
ATOM   681  O O   . ASN A 1 87  ? -24.15241  -18.22491 -109.91716 1.000 28.75524 ? 87  ASN A O   1 
ATOM   682  C CB  . ASN A 1 87  ? -25.46479  -15.10540 -110.21617 1.000 29.35658 ? 87  ASN A CB  1 
ATOM   683  C CG  . ASN A 1 87  ? -25.52651  -13.74888 -110.87990 1.000 32.65486 ? 87  ASN A CG  1 
ATOM   684  O OD1 . ASN A 1 87  ? -24.50655  -13.21329 -111.30896 1.000 39.08152 ? 87  ASN A OD1 1 
ATOM   685  N ND2 . ASN A 1 87  ? -26.73160  -13.18587 -110.97966 1.000 31.09326 ? 87  ASN A ND2 1 
ATOM   686  N N   . GLN A 1 88  ? -23.55456  -16.60711 -108.44732 1.000 31.19386 ? 88  GLN A N   1 
ATOM   687  C CA  . GLN A 1 88  ? -23.41696  -17.48345 -107.28834 1.000 29.44422 ? 88  GLN A CA  1 
ATOM   688  C C   . GLN A 1 88  ? -22.64273  -18.76656 -107.62719 1.000 25.73516 ? 88  GLN A C   1 
ATOM   689  O O   . GLN A 1 88  ? -22.92494  -19.85257 -107.11849 1.000 25.94737 ? 88  GLN A O   1 
ATOM   690  C CB  . GLN A 1 88  ? -24.79658  -17.76752 -106.67981 1.000 27.81062 ? 88  GLN A CB  1 
ATOM   691  C CG  . GLN A 1 88  ? -25.36503  -16.52988 -105.95985 1.000 27.15276 ? 88  GLN A CG  1 
ATOM   692  C CD  . GLN A 1 88  ? -26.69039  -16.76362 -105.28313 1.000 30.78777 ? 88  GLN A CD  1 
ATOM   693  O OE1 . GLN A 1 88  ? -27.74560  -16.41378 -105.81586 1.000 33.07702 ? 88  GLN A OE1 1 
ATOM   694  N NE2 . GLN A 1 88  ? -26.65149  -17.35636 -104.09705 1.000 33.05736 ? 88  GLN A NE2 1 
ATOM   695  N N   . THR A 1 89  ? -21.63447  -18.62870 -108.48445 1.000 28.18245 ? 89  THR A N   1 
ATOM   696  C CA  . THR A 1 89  ? -20.68240  -19.68208 -108.79790 1.000 33.56123 ? 89  THR A CA  1 
ATOM   697  C C   . THR A 1 89  ? -19.28125  -19.21275 -108.43560 1.000 31.37873 ? 89  THR A C   1 
ATOM   698  O O   . THR A 1 89  ? -18.86418  -18.14320 -108.89944 1.000 40.72299 ? 89  THR A O   1 
ATOM   699  C CB  . THR A 1 89  ? -20.73816  -20.03903 -110.29173 1.000 33.14732 ? 89  THR A CB  1 
ATOM   700  O OG1 . THR A 1 89  ? -22.05898  -20.48883 -110.62061 1.000 30.99571 ? 89  THR A OG1 1 
ATOM   701  C CG2 . THR A 1 89  ? -19.72237  -21.13402 -110.62565 1.000 28.58525 ? 89  THR A CG2 1 
ATOM   702  N N   . PRO A 1 90  ? -18.52373  -19.96221 -107.63325 1.000 32.64563 ? 90  PRO A N   1 
ATOM   703  C CA  . PRO A 1 90  ? -17.21139  -19.47015 -107.18725 1.000 31.41607 ? 90  PRO A CA  1 
ATOM   704  C C   . PRO A 1 90  ? -16.21749  -19.36672 -108.33842 1.000 30.62648 ? 90  PRO A C   1 
ATOM   705  O O   . PRO A 1 90  ? -16.35356  -20.00622 -109.38425 1.000 30.90279 ? 90  PRO A O   1 
ATOM   706  C CB  . PRO A 1 90  ? -16.76418  -20.51620 -106.15924 1.000 29.94799 ? 90  PRO A CB  1 
ATOM   707  C CG  . PRO A 1 90  ? -18.02358  -21.28853 -105.80117 1.000 29.45518 ? 90  PRO A CG  1 
ATOM   708  C CD  . PRO A 1 90  ? -18.82012  -21.29109 -107.07868 1.000 30.46781 ? 90  PRO A CD  1 
ATOM   709  N N   . ASP A 1 91  ? -15.19305  -18.53343 -108.13075 1.000 40.39548 ? 91  ASP A N   1 
ATOM   710  C CA  . ASP A 1 91  ? -14.21695  -18.29209 -109.19414 1.000 37.94663 ? 91  ASP A CA  1 
ATOM   711  C C   . ASP A 1 91  ? -13.40084  -19.53507 -109.51560 1.000 35.12709 ? 91  ASP A C   1 
ATOM   712  O O   . ASP A 1 91  ? -12.94251  -19.68799 -110.65476 1.000 37.37229 ? 91  ASP A O   1 
ATOM   713  C CB  . ASP A 1 91  ? -13.26677  -17.14448 -108.81869 1.000 38.52752 ? 91  ASP A CB  1 
ATOM   714  C CG  . ASP A 1 91  ? -13.96187  -15.79846 -108.76004 1.000 45.25652 ? 91  ASP A CG  1 
ATOM   715  O OD1 . ASP A 1 91  ? -14.88228  -15.55520 -109.56838 1.000 48.40170 ? 91  ASP A OD1 1 
ATOM   716  O OD2 . ASP A 1 91  ? -13.58434  -14.97665 -107.90227 1.000 48.52216 ? 91  ASP A OD2 1 
ATOM   717  N N   . TRP A 1 92  ? -13.19136  -20.41856 -108.53284 1.000 33.87532 ? 92  TRP A N   1 
ATOM   718  C CA  . TRP A 1 92  ? -12.33133  -21.57647 -108.75658 1.000 32.75762 ? 92  TRP A CA  1 
ATOM   719  C C   . TRP A 1 92  ? -12.78777  -22.39036 -109.95537 1.000 33.74759 ? 92  TRP A C   1 
ATOM   720  O O   . TRP A 1 92  ? -11.95526  -22.96787 -110.66226 1.000 39.30292 ? 92  TRP A O   1 
ATOM   721  C CB  . TRP A 1 92  ? -12.26990  -22.45925 -107.50406 1.000 33.05602 ? 92  TRP A CB  1 
ATOM   722  C CG  . TRP A 1 92  ? -13.45902  -23.39212 -107.23099 1.000 24.55183 ? 92  TRP A CG  1 
ATOM   723  C CD1 . TRP A 1 92  ? -14.37749  -23.25171 -106.23914 1.000 25.07780 ? 92  TRP A CD1 1 
ATOM   724  C CD2 . TRP A 1 92  ? -13.80474  -24.61825 -107.92201 1.000 27.37314 ? 92  TRP A CD2 1 
ATOM   725  N NE1 . TRP A 1 92  ? -15.28811  -24.28649 -106.27599 1.000 24.97163 ? 92  TRP A NE1 1 
ATOM   726  C CE2 . TRP A 1 92  ? -14.95799  -25.14073 -107.29312 1.000 28.82805 ? 92  TRP A CE2 1 
ATOM   727  C CE3 . TRP A 1 92  ? -13.25073  -25.32202 -109.00236 1.000 26.34979 ? 92  TRP A CE3 1 
ATOM   728  C CZ2 . TRP A 1 92  ? -15.58141  -26.32683 -107.71835 1.000 27.69922 ? 92  TRP A CZ2 1 
ATOM   729  C CZ3 . TRP A 1 92  ? -13.87086  -26.50378 -109.43205 1.000 27.67373 ? 92  TRP A CZ3 1 
ATOM   730  C CH2 . TRP A 1 92  ? -15.02577  -26.99148 -108.78749 1.000 26.26602 ? 92  TRP A CH2 1 
ATOM   731  N N   . VAL A 1 93  ? -14.09988  -22.43660 -110.20067 1.000 28.15394 ? 93  VAL A N   1 
ATOM   732  C CA  . VAL A 1 93  ? -14.67371  -23.22562 -111.28894 1.000 31.33987 ? 93  VAL A CA  1 
ATOM   733  C C   . VAL A 1 93  ? -14.03287  -22.88782 -112.62244 1.000 27.83055 ? 93  VAL A C   1 
ATOM   734  O O   . VAL A 1 93  ? -13.90225  -23.74988 -113.50243 1.000 27.23368 ? 93  VAL A O   1 
ATOM   735  C CB  . VAL A 1 93  ? -16.20653  -23.00368 -111.33109 1.000 27.37361 ? 93  VAL A CB  1 
ATOM   736  C CG1 . VAL A 1 93  ? -16.83529  -23.74905 -112.47917 1.000 25.14099 ? 93  VAL A CG1 1 
ATOM   737  C CG2 . VAL A 1 93  ? -16.80615  -23.45315 -110.06218 1.000 22.85533 ? 93  VAL A CG2 1 
ATOM   738  N N   . PHE A 1 94  ? -13.64625  -21.63621 -112.81456 1.000 30.05141 ? 94  PHE A N   1 
ATOM   739  C CA  . PHE A 1 94  ? -13.23442  -21.18780 -114.13521 1.000 38.69905 ? 94  PHE A CA  1 
ATOM   740  C C   . PHE A 1 94  ? -11.72504  -21.01825 -114.26288 1.000 44.32216 ? 94  PHE A C   1 
ATOM   741  O O   . PHE A 1 94  ? -11.24539  -20.71984 -115.36193 1.000 45.73651 ? 94  PHE A O   1 
ATOM   742  C CB  . PHE A 1 94  ? -13.95251  -19.87410 -114.48142 1.000 35.41288 ? 94  PHE A CB  1 
ATOM   743  C CG  . PHE A 1 94  ? -15.45274  -19.92770 -114.28512 1.000 35.54844 ? 94  PHE A CG  1 
ATOM   744  C CD1 . PHE A 1 94  ? -16.27234  -20.53062 -115.23089 1.000 35.03432 ? 94  PHE A CD1 1 
ATOM   745  C CD2 . PHE A 1 94  ? -16.03741  -19.38883 -113.15206 1.000 35.60329 ? 94  PHE A CD2 1 
ATOM   746  C CE1 . PHE A 1 94  ? -17.65037  -20.58424 -115.05291 1.000 37.70197 ? 94  PHE A CE1 1 
ATOM   747  C CE2 . PHE A 1 94  ? -17.41131  -19.43911 -112.96749 1.000 33.21119 ? 94  PHE A CE2 1 
ATOM   748  C CZ  . PHE A 1 94  ? -18.21961  -20.04043 -113.91972 1.000 30.67598 ? 94  PHE A CZ  1 
ATOM   749  N N   . GLN A 1 95  ? -10.96789  -21.22398 -113.18210 1.000 40.82338 ? 95  GLN A N   1 
ATOM   750  C CA  . GLN A 1 95  ? -9.53873   -20.95285 -113.12841 1.000 45.55196 ? 95  GLN A CA  1 
ATOM   751  C C   . GLN A 1 95  ? -8.71718   -22.23349 -113.02333 1.000 46.57146 ? 95  GLN A C   1 
ATOM   752  O O   . GLN A 1 95  ? -9.20970   -23.29820 -112.63901 1.000 45.79914 ? 95  GLN A O   1 
ATOM   753  C CB  . GLN A 1 95  ? -9.20418   -20.04249 -111.94154 1.000 41.49105 ? 95  GLN A CB  1 
ATOM   754  C CG  . GLN A 1 95  ? -10.00655  -18.76549 -111.92121 1.000 44.42089 ? 95  GLN A CG  1 
ATOM   755  C CD  . GLN A 1 95  ? -9.79230   -17.94139 -110.66210 1.000 47.46652 ? 95  GLN A CD  1 
ATOM   756  O OE1 . GLN A 1 95  ? -9.46289   -18.47412 -109.59287 1.000 40.95916 ? 95  GLN A OE1 1 
ATOM   757  N NE2 . GLN A 1 95  ? -10.03399  -16.63554 -110.77088 1.000 46.14741 ? 95  GLN A NE2 1 
ATOM   758  N N   . ASP A 1 96  ? -7.44002   -22.11239 -113.37134 1.000 55.03411 ? 96  ASP A N   1 
ATOM   759  C CA  . ASP A 1 96  ? -6.46883   -23.16163 -113.09460 1.000 56.31736 ? 96  ASP A CA  1 
ATOM   760  C C   . ASP A 1 96  ? -5.62552   -22.75695 -111.87892 1.000 54.62660 ? 96  ASP A C   1 
ATOM   761  O O   . ASP A 1 96  ? -5.96402   -21.81274 -111.15475 1.000 58.29448 ? 96  ASP A O   1 
ATOM   762  C CB  . ASP A 1 96  ? -5.62700   -23.45256 -114.35491 1.000 58.45426 ? 96  ASP A CB  1 
ATOM   763  C CG  . ASP A 1 96  ? -4.83278   -22.23250 -114.85832 1.000 59.17573 ? 96  ASP A CG  1 
ATOM   764  O OD1 . ASP A 1 96  ? -4.57909   -21.28097 -114.09013 1.000 53.90404 ? 96  ASP A OD1 1 
ATOM   765  O OD2 . ASP A 1 96  ? -4.44351   -22.24286 -116.04775 1.000 56.31344 ? 96  ASP A OD2 1 
ATOM   766  N N   . GLY A 1 97  ? -4.51988   -23.46225 -111.64561 1.000 62.00698 ? 97  GLY A N   1 
ATOM   767  C CA  . GLY A 1 97  ? -3.64811   -23.07854 -110.55059 1.000 62.77419 ? 97  GLY A CA  1 
ATOM   768  C C   . GLY A 1 97  ? -3.06931   -21.68820 -110.72220 1.000 63.76693 ? 97  GLY A C   1 
ATOM   769  O O   . GLY A 1 97  ? -2.92527   -20.94088 -109.74944 1.000 61.47886 ? 97  GLY A O   1 
ATOM   770  N N   . GLN A 1 98  ? -2.74615   -21.31543 -111.96755 1.000 62.52984 ? 98  GLN A N   1 
ATOM   771  C CA  . GLN A 1 98  ? -2.09903   -20.03564 -112.22509 1.000 58.98662 ? 98  GLN A CA  1 
ATOM   772  C C   . GLN A 1 98  ? -3.04324   -18.84503 -112.10414 1.000 64.08488 ? 98  GLN A C   1 
ATOM   773  O O   . GLN A 1 98  ? -2.57148   -17.70409 -112.04221 1.000 70.51275 ? 98  GLN A O   1 
ATOM   774  C CB  . GLN A 1 98  ? -1.44756   -20.06828 -113.60625 1.000 63.29486 ? 98  GLN A CB  1 
ATOM   775  C CG  . GLN A 1 98  ? -0.38796   -21.21832 -113.77698 1.000 78.27313 ? 98  GLN A CG  1 
ATOM   776  C CD  . GLN A 1 98  ? 0.49857    -21.48333 -112.52225 1.000 80.56268 ? 98  GLN A CD  1 
ATOM   777  O OE1 . GLN A 1 98  ? 0.92156    -22.64159 -112.26744 1.000 82.70871 ? 98  GLN A OE1 1 
ATOM   778  N NE2 . GLN A 1 98  ? 0.83831    -20.41378 -111.77602 1.000 76.12556 ? 98  GLN A NE2 1 
ATOM   779  N N   . GLY A 1 99  ? -4.35453   -19.07324 -112.01895 1.000 65.18747 ? 99  GLY A N   1 
ATOM   780  C CA  . GLY A 1 99  ? -5.31902   -17.99080 -112.02414 1.000 62.27183 ? 99  GLY A CA  1 
ATOM   781  C C   . GLY A 1 99  ? -5.91190   -17.68384 -113.38549 1.000 70.03652 ? 99  GLY A C   1 
ATOM   782  O O   . GLY A 1 99  ? -6.80501   -16.82792 -113.47591 1.000 66.43327 ? 99  GLY A O   1 
ATOM   783  N N   . HIS A 1 100 ? -5.45994   -18.36164 -114.44260 1.000 61.23898 ? 100 HIS A N   1 
ATOM   784  C CA  . HIS A 1 100 ? -5.97618   -18.15605 -115.78525 1.000 62.66594 ? 100 HIS A CA  1 
ATOM   785  C C   . HIS A 1 100 ? -7.20554   -19.03677 -116.01536 1.000 52.19963 ? 100 HIS A C   1 
ATOM   786  O O   . HIS A 1 100 ? -7.47286   -19.98583 -115.27834 1.000 51.98133 ? 100 HIS A O   1 
ATOM   787  C CB  . HIS A 1 100 ? -4.89753   -18.46155 -116.83092 1.000 58.25773 ? 100 HIS A CB  1 
ATOM   788  C CG  . HIS A 1 100 ? -3.52275   -18.00728 -116.43781 1.000 73.70091 ? 100 HIS A CG  1 
ATOM   789  N ND1 . HIS A 1 100 ? -3.30254   -17.02176 -115.49799 1.000 78.50496 ? 100 HIS A ND1 1 
ATOM   790  C CD2 . HIS A 1 100 ? -2.29622   -18.42828 -116.83171 1.000 66.93190 ? 100 HIS A CD2 1 
ATOM   791  C CE1 . HIS A 1 100 ? -2.00336   -16.84556 -115.33875 1.000 74.25652 ? 100 HIS A CE1 1 
ATOM   792  N NE2 . HIS A 1 100 ? -1.37021   -17.68588 -116.13700 1.000 76.90421 ? 100 HIS A NE2 1 
ATOM   793  N N   . PHE A 1 101 ? -7.95145   -18.71524 -117.06429 1.000 41.27951 ? 101 PHE A N   1 
ATOM   794  C CA  . PHE A 1 101 ? -9.13565   -19.48547 -117.41226 1.000 49.21371 ? 101 PHE A CA  1 
ATOM   795  C C   . PHE A 1 101 ? -8.76434   -20.88551 -117.89402 1.000 47.33015 ? 101 PHE A C   1 
ATOM   796  O O   . PHE A 1 101 ? -7.74795   -21.08499 -118.56926 1.000 50.17156 ? 101 PHE A O   1 
ATOM   797  C CB  . PHE A 1 101 ? -9.93694   -18.74968 -118.48346 1.000 44.85196 ? 101 PHE A CB  1 
ATOM   798  C CG  . PHE A 1 101 ? -10.58421  -17.49030 -117.98061 1.000 54.50703 ? 101 PHE A CG  1 
ATOM   799  C CD1 . PHE A 1 101 ? -11.23687  -17.48155 -116.76027 1.000 51.91158 ? 101 PHE A CD1 1 
ATOM   800  C CD2 . PHE A 1 101 ? -10.55108  -16.32104 -118.72297 1.000 60.71936 ? 101 PHE A CD2 1 
ATOM   801  C CE1 . PHE A 1 101 ? -11.84253  -16.33291 -116.28591 1.000 51.10895 ? 101 PHE A CE1 1 
ATOM   802  C CE2 . PHE A 1 101 ? -11.15851  -15.17100 -118.25039 1.000 53.27086 ? 101 PHE A CE2 1 
ATOM   803  C CZ  . PHE A 1 101 ? -11.80389  -15.18267 -117.02951 1.000 54.04964 ? 101 PHE A CZ  1 
ATOM   804  N N   . VAL A 1 102 ? -9.60450   -21.86529 -117.53672 1.000 38.82396 ? 102 VAL A N   1 
ATOM   805  C CA  . VAL A 1 102 ? -9.37464   -23.25785 -117.90430 1.000 36.40653 ? 102 VAL A CA  1 
ATOM   806  C C   . VAL A 1 102 ? -9.78435   -23.46875 -119.34931 1.000 38.36731 ? 102 VAL A C   1 
ATOM   807  O O   . VAL A 1 102 ? -10.34619  -22.56874 -119.99014 1.000 42.19444 ? 102 VAL A O   1 
ATOM   808  C CB  . VAL A 1 102 ? -10.14209  -24.23576 -116.99339 1.000 38.07835 ? 102 VAL A CB  1 
ATOM   809  C CG1 . VAL A 1 102 ? -9.56188   -24.23475 -115.60890 1.000 38.19381 ? 102 VAL A CG1 1 
ATOM   810  C CG2 . VAL A 1 102 ? -11.64927  -23.92711 -116.98380 1.000 41.42357 ? 102 VAL A CG2 1 
ATOM   811  N N   . SER A 1 103 ? -9.53069   -24.67057 -119.85826 1.000 38.70988 ? 103 SER A N   1 
ATOM   812  C CA  . SER A 1 103 ? -9.95350   -25.02271 -121.19770 1.000 42.69465 ? 103 SER A CA  1 
ATOM   813  C C   . SER A 1 103 ? -11.43354  -25.40615 -121.21451 1.000 43.77412 ? 103 SER A C   1 
ATOM   814  O O   . SER A 1 103 ? -12.06978  -25.59478 -120.17427 1.000 42.03503 ? 103 SER A O   1 
ATOM   815  C CB  . SER A 1 103 ? -9.08740   -26.16393 -121.73328 1.000 31.64914 ? 103 SER A CB  1 
ATOM   816  O OG  . SER A 1 103 ? -9.35744   -27.37439 -121.04305 1.000 52.07603 ? 103 SER A OG  1 
ATOM   817  N N   . ARG A 1 104 ? -11.97487  -25.51074 -122.43317 1.000 41.26927 ? 104 ARG A N   1 
ATOM   818  C CA  . ARG A 1 104 ? -13.32087  -26.02450 -122.62727 1.000 37.14877 ? 104 ARG A CA  1 
ATOM   819  C C   . ARG A 1 104 ? -13.46144  -27.42555 -122.04450 1.000 42.60357 ? 104 ARG A C   1 
ATOM   820  O O   . ARG A 1 104 ? -14.45391  -27.73370 -121.37417 1.000 42.48142 ? 104 ARG A O   1 
ATOM   821  C CB  . ARG A 1 104 ? -13.66503  -26.01391 -124.12141 1.000 31.46113 ? 104 ARG A CB  1 
ATOM   822  C CG  . ARG A 1 104 ? -14.71937  -27.04991 -124.50658 1.000 34.60550 ? 104 ARG A CG  1 
ATOM   823  C CD  . ARG A 1 104 ? -14.88480  -27.22331 -126.00569 1.000 33.11313 ? 104 ARG A CD  1 
ATOM   824  N NE  . ARG A 1 104 ? -15.90066  -28.22962 -126.30803 1.000 39.97217 ? 104 ARG A NE  1 
ATOM   825  C CZ  . ARG A 1 104 ? -17.19307  -27.94769 -126.46388 1.000 41.82924 ? 104 ARG A CZ  1 
ATOM   826  N NH1 . ARG A 1 104 ? -17.60581  -26.69363 -126.35923 1.000 36.82736 ? 104 ARG A NH1 1 
ATOM   827  N NH2 . ARG A 1 104 ? -18.07375  -28.91122 -126.72767 1.000 37.56107 ? 104 ARG A NH2 1 
ATOM   828  N N   . ASP A 1 105 ? -12.47135  -28.29401 -122.28336 1.000 38.25672 ? 105 ASP A N   1 
ATOM   829  C CA  . ASP A 1 105 ? -12.55240  -29.66116 -121.77676 1.000 42.28763 ? 105 ASP A CA  1 
ATOM   830  C C   . ASP A 1 105 ? -12.48975  -29.70551 -120.25805 1.000 40.00247 ? 105 ASP A C   1 
ATOM   831  O O   . ASP A 1 105 ? -13.14833  -30.55189 -119.63951 1.000 37.36164 ? 105 ASP A O   1 
ATOM   832  C CB  . ASP A 1 105 ? -11.43086  -30.52257 -122.36102 1.000 41.31147 ? 105 ASP A CB  1 
ATOM   833  C CG  . ASP A 1 105 ? -11.57835  -30.73149 -123.84875 1.000 42.38602 ? 105 ASP A CG  1 
ATOM   834  O OD1 . ASP A 1 105 ? -12.65658  -30.40988 -124.38660 1.000 40.22395 ? 105 ASP A OD1 1 
ATOM   835  O OD2 . ASP A 1 105 ? -10.61826  -31.21691 -124.47918 1.000 44.97609 ? 105 ASP A OD2 1 
ATOM   836  N N   . VAL A 1 106 ? -11.70408  -28.81756 -119.64155 1.000 34.90493 ? 106 VAL A N   1 
ATOM   837  C CA  . VAL A 1 106 ? -11.58235  -28.82334 -118.18536 1.000 36.86369 ? 106 VAL A CA  1 
ATOM   838  C C   . VAL A 1 106 ? -12.87412  -28.32416 -117.54074 1.000 38.66591 ? 106 VAL A C   1 
ATOM   839  O O   . VAL A 1 106 ? -13.39088  -28.93513 -116.59862 1.000 40.46587 ? 106 VAL A O   1 
ATOM   840  C CB  . VAL A 1 106 ? -10.35822  -28.00185 -117.74065 1.000 40.10065 ? 106 VAL A CB  1 
ATOM   841  C CG1 . VAL A 1 106 ? -10.39352  -27.72251 -116.24119 1.000 33.16776 ? 106 VAL A CG1 1 
ATOM   842  C CG2 . VAL A 1 106 ? -9.08790   -28.75074 -118.08603 1.000 37.36451 ? 106 VAL A CG2 1 
ATOM   843  N N   . LEU A 1 107 ? -13.43412  -27.22618 -118.05688 1.000 37.27196 ? 107 LEU A N   1 
ATOM   844  C CA  . LEU A 1 107 ? -14.69198  -26.73011 -117.50864 1.000 37.06920 ? 107 LEU A CA  1 
ATOM   845  C C   . LEU A 1 107 ? -15.80714  -27.75735 -117.68512 1.000 35.14050 ? 107 LEU A C   1 
ATOM   846  O O   . LEU A 1 107 ? -16.61973  -27.95475 -116.77545 1.000 36.20105 ? 107 LEU A O   1 
ATOM   847  C CB  . LEU A 1 107 ? -15.06106  -25.38564 -118.14549 1.000 32.23999 ? 107 LEU A CB  1 
ATOM   848  C CG  . LEU A 1 107 ? -16.17279  -24.61261 -117.42463 1.000 28.87577 ? 107 LEU A CG  1 
ATOM   849  C CD1 . LEU A 1 107 ? -15.85769  -24.42149 -115.95413 1.000 29.58454 ? 107 LEU A CD1 1 
ATOM   850  C CD2 . LEU A 1 107 ? -16.41843  -23.26901 -118.07980 1.000 29.47721 ? 107 LEU A CD2 1 
ATOM   851  N N   . LEU A 1 108 ? -15.83595  -28.45753 -118.82710 1.000 35.18006 ? 108 LEU A N   1 
ATOM   852  C CA  . LEU A 1 108 ? -16.84007  -29.50430 -119.01501 1.000 35.75912 ? 108 LEU A CA  1 
ATOM   853  C C   . LEU A 1 108 ? -16.68592  -30.61708 -117.98133 1.000 32.27081 ? 108 LEU A C   1 
ATOM   854  O O   . LEU A 1 108 ? -17.68597  -31.10464 -117.43864 1.000 30.90232 ? 108 LEU A O   1 
ATOM   855  C CB  . LEU A 1 108 ? -16.77154  -30.07652 -120.42625 1.000 29.87512 ? 108 LEU A CB  1 
ATOM   856  C CG  . LEU A 1 108 ? -17.35092  -29.20334 -121.53601 1.000 39.14372 ? 108 LEU A CG  1 
ATOM   857  C CD1 . LEU A 1 108 ? -17.16585  -29.86029 -122.90883 1.000 35.19377 ? 108 LEU A CD1 1 
ATOM   858  C CD2 . LEU A 1 108 ? -18.80256  -28.90218 -121.27942 1.000 33.41485 ? 108 LEU A CD2 1 
ATOM   859  N N   . GLU A 1 109 ? -15.44449  -31.02825 -117.68983 1.000 33.45196 ? 109 GLU A N   1 
ATOM   860  C CA  . GLU A 1 109 ? -15.21824  -32.03680 -116.65269 1.000 34.33700 ? 109 GLU A CA  1 
ATOM   861  C C   . GLU A 1 109 ? -15.73705  -31.56195 -115.30204 1.000 27.56695 ? 109 GLU A C   1 
ATOM   862  O O   . GLU A 1 109 ? -16.41863  -32.30672 -114.59374 1.000 29.77733 ? 109 GLU A O   1 
ATOM   863  C CB  . GLU A 1 109 ? -13.72855  -32.38549 -116.53852 1.000 36.43207 ? 109 GLU A CB  1 
ATOM   864  C CG  . GLU A 1 109 ? -13.14571  -33.16538 -117.70328 1.000 54.97549 ? 109 GLU A CG  1 
ATOM   865  C CD  . GLU A 1 109 ? -11.63254  -33.37773 -117.58399 1.000 67.09652 ? 109 GLU A CD  1 
ATOM   866  O OE1 . GLU A 1 109 ? -10.98405  -32.71246 -116.73673 1.000 54.99385 ? 109 GLU A OE1 1 
ATOM   867  O OE2 . GLU A 1 109 ? -11.09071  -34.19646 -118.36237 1.000 66.33890 ? 109 GLU A OE2 1 
ATOM   868  N N   . ARG A 1 110 ? -15.40293  -30.32322 -114.92605 1.000 27.15047 ? 110 ARG A N   1 
ATOM   869  C CA  . ARG A 1 110 ? -15.89896  -29.74136 -113.68281 1.000 32.49028 ? 110 ARG A CA  1 
ATOM   870  C C   . ARG A 1 110 ? -17.42157  -29.63043 -113.68528 1.000 29.49725 ? 110 ARG A C   1 
ATOM   871  O O   . ARG A 1 110 ? -18.07457  -29.91520 -112.67481 1.000 32.95877 ? 110 ARG A O   1 
ATOM   872  C CB  . ARG A 1 110 ? -15.26748  -28.36654 -113.48230 1.000 25.60199 ? 110 ARG A CB  1 
ATOM   873  C CG  . ARG A 1 110 ? -13.78680  -28.44524 -113.26530 1.000 30.97554 ? 110 ARG A CG  1 
ATOM   874  C CD  . ARG A 1 110 ? -13.15008  -27.08167 -113.11682 1.000 27.40061 ? 110 ARG A CD  1 
ATOM   875  N NE  . ARG A 1 110 ? -11.74014  -27.20562 -112.76101 1.000 37.52850 ? 110 ARG A NE  1 
ATOM   876  C CZ  . ARG A 1 110 ? -10.92923  -26.17835 -112.53705 1.000 38.26292 ? 110 ARG A CZ  1 
ATOM   877  N NH1 . ARG A 1 110 ? -11.38566  -24.93603 -112.63444 1.000 32.67659 ? 110 ARG A NH1 1 
ATOM   878  N NH2 . ARG A 1 110 ? -9.66376   -26.39316 -112.19610 1.000 40.72419 ? 110 ARG A NH2 1 
ATOM   879  N N   . MET A 1 111 ? -18.00497  -29.19895 -114.80350 1.000 24.92621 ? 111 MET A N   1 
ATOM   880  C CA  . MET A 1 111 ? -19.45495  -29.09595 -114.87537 1.000 25.95534 ? 111 MET A CA  1 
ATOM   881  C C   . MET A 1 111 ? -20.09943  -30.46466 -114.68032 1.000 26.13994 ? 111 MET A C   1 
ATOM   882  O O   . MET A 1 111 ? -20.97817  -30.62684 -113.82908 1.000 25.84580 ? 111 MET A O   1 
ATOM   883  C CB  . MET A 1 111 ? -19.87430  -28.46733 -116.20779 1.000 24.40653 ? 111 MET A CB  1 
ATOM   884  C CG  . MET A 1 111 ? -21.37441  -28.31648 -116.34902 1.000 21.86661 ? 111 MET A CG  1 
ATOM   885  S SD  . MET A 1 111 ? -21.98065  -27.99798 -118.02351 1.000 27.47973 ? 111 MET A SD  1 
ATOM   886  C CE  . MET A 1 111 ? -21.50823  -26.28027 -118.12205 1.000 25.16246 ? 111 MET A CE  1 
ATOM   887  N N   . LYS A 1 112 ? -19.62517  -31.47716 -115.42349 1.000 28.88594 ? 112 LYS A N   1 
ATOM   888  C CA  . LYS A 1 112 ? -20.18085  -32.82325 -115.30759 1.000 22.75752 ? 112 LYS A CA  1 
ATOM   889  C C   . LYS A 1 112 ? -19.99174  -33.38551 -113.90525 1.000 29.82940 ? 112 LYS A C   1 
ATOM   890  O O   . LYS A 1 112 ? -20.85233  -34.10217 -113.38660 1.000 27.33048 ? 112 LYS A O   1 
ATOM   891  C CB  . LYS A 1 112 ? -19.53585  -33.75685 -116.33383 1.000 31.44325 ? 112 LYS A CB  1 
ATOM   892  C CG  . LYS A 1 112 ? -20.22948  -35.10491 -116.39001 1.000 36.15503 ? 112 LYS A CG  1 
ATOM   893  C CD  . LYS A 1 112 ? -19.57252  -36.13570 -117.26429 1.000 32.90641 ? 112 LYS A CD  1 
ATOM   894  C CE  . LYS A 1 112 ? -19.98673  -37.54056 -116.84223 1.000 51.00162 ? 112 LYS A CE  1 
ATOM   895  N NZ  . LYS A 1 112 ? -18.82341  -38.19920 -116.20656 1.000 65.33229 ? 112 LYS A NZ  1 
ATOM   896  N N   . CYS A 1 113 ? -18.86371  -33.08833 -113.27874 1.000 22.51893 ? 113 CYS A N   1 
ATOM   897  C CA  . CYS A 1 113 ? -18.62398  -33.69036 -111.98288 1.000 25.98682 ? 113 CYS A CA  1 
ATOM   898  C C   . CYS A 1 113 ? -19.52280  -33.05338 -110.94291 1.000 27.08718 ? 113 CYS A C   1 
ATOM   899  O O   . CYS A 1 113 ? -20.04254  -33.73987 -110.05268 1.000 25.98609 ? 113 CYS A O   1 
ATOM   900  C CB  . CYS A 1 113 ? -17.14700  -33.55855 -111.60466 1.000 24.95729 ? 113 CYS A CB  1 
ATOM   901  S SG  . CYS A 1 113 ? -16.81291  -34.11517 -109.92117 1.000 35.77411 ? 113 CYS A SG  1 
ATOM   902  N N   . HIS A 1 114 ? -19.74225  -31.74221 -111.06238 1.000 28.62890 ? 114 HIS A N   1 
ATOM   903  C CA  . HIS A 1 114 ? -20.67285  -31.06225 -110.16893 1.000 23.74276 ? 114 HIS A CA  1 
ATOM   904  C C   . HIS A 1 114 ? -22.09072  -31.57108 -110.38014 1.000 20.34425 ? 114 HIS A C   1 
ATOM   905  O O   . HIS A 1 114 ? -22.77503  -31.95503 -109.42951 1.000 27.43309 ? 114 HIS A O   1 
ATOM   906  C CB  . HIS A 1 114 ? -20.60679  -29.55178 -110.39054 1.000 26.59191 ? 114 HIS A CB  1 
ATOM   907  C CG  . HIS A 1 114 ? -21.51265  -28.78248 -109.48313 1.000 26.72499 ? 114 HIS A CG  1 
ATOM   908  N ND1 . HIS A 1 114 ? -21.11649  -28.33615 -108.24107 1.000 27.55065 ? 114 HIS A ND1 1 
ATOM   909  C CD2 . HIS A 1 114 ? -22.80419  -28.39855 -109.62730 1.000 21.49265 ? 114 HIS A CD2 1 
ATOM   910  C CE1 . HIS A 1 114 ? -22.12114  -27.69972 -107.66379 1.000 26.40162 ? 114 HIS A CE1 1 
ATOM   911  N NE2 . HIS A 1 114 ? -23.15620  -27.72579 -108.48320 1.000 24.23560 ? 114 HIS A NE2 1 
ATOM   912  N N   . ILE A 1 115 ? -22.54435  -31.58396 -111.63103 1.000 27.82309 ? 115 ILE A N   1 
ATOM   913  C CA  . ILE A 1 115 ? -23.89688  -32.02663 -111.93651 1.000 21.49356 ? 115 ILE A CA  1 
ATOM   914  C C   . ILE A 1 115 ? -24.10675  -33.46759 -111.47680 1.000 26.81122 ? 115 ILE A C   1 
ATOM   915  O O   . ILE A 1 115 ? -25.12877  -33.79584 -110.86041 1.000 30.36884 ? 115 ILE A O   1 
ATOM   916  C CB  . ILE A 1 115 ? -24.16958  -31.84460 -113.44346 1.000 21.73742 ? 115 ILE A CB  1 
ATOM   917  C CG1 . ILE A 1 115 ? -24.28800  -30.36120 -113.77670 1.000 17.08316 ? 115 ILE A CG1 1 
ATOM   918  C CG2 . ILE A 1 115 ? -25.40295  -32.61337 -113.88687 1.000 18.45267 ? 115 ILE A CG2 1 
ATOM   919  C CD1 . ILE A 1 115 ? -24.46312  -30.06907 -115.27039 1.000 19.37281 ? 115 ILE A CD1 1 
ATOM   920  N N   A SER A 1 116 ? -23.14214  -34.34616 -111.75682 0.422 25.01237 ? 116 SER A N   1 
ATOM   921  N N   B SER A 1 116 ? -23.14041  -34.34678 -111.75122 0.578 24.27772 ? 116 SER A N   1 
ATOM   922  C CA  A SER A 1 116 ? -23.29426  -35.74897 -111.37949 0.422 27.24526 ? 116 SER A CA  1 
ATOM   923  C CA  B SER A 1 116 ? -23.29954  -35.74971 -111.37396 0.578 26.98266 ? 116 SER A CA  1 
ATOM   924  C C   A SER A 1 116 ? -23.35476  -35.91514 -109.86494 0.422 26.85224 ? 116 SER A C   1 
ATOM   925  C C   B SER A 1 116 ? -23.35267  -35.91829 -109.85970 0.578 27.58236 ? 116 SER A C   1 
ATOM   926  O O   A SER A 1 116 ? -24.19007  -36.66573 -109.34786 0.422 28.44075 ? 116 SER A O   1 
ATOM   927  O O   B SER A 1 116 ? -24.17756  -36.67785 -109.33861 0.578 28.45381 ? 116 SER A O   1 
ATOM   928  C CB  A SER A 1 116 ? -22.14793  -36.57759 -111.95813 0.422 26.60337 ? 116 SER A CB  1 
ATOM   929  C CB  B SER A 1 116 ? -22.16364  -36.58966 -111.95530 0.578 26.55505 ? 116 SER A CB  1 
ATOM   930  O OG  A SER A 1 116 ? -22.12678  -36.49562 -113.37192 0.422 29.67360 ? 116 SER A OG  1 
ATOM   931  O OG  B SER A 1 116 ? -22.45728  -37.97070 -111.83735 0.578 30.20938 ? 116 SER A OG  1 
ATOM   932  N N   . THR A 1 117 ? -22.48022  -35.22203 -109.13608 1.000 21.63268 ? 117 THR A N   1 
ATOM   933  C CA  . THR A 1 117 ? -22.45743  -35.36740 -107.68664 1.000 23.13876 ? 117 THR A CA  1 
ATOM   934  C C   . THR A 1 117 ? -23.72447  -34.79239 -107.06141 1.000 24.93904 ? 117 THR A C   1 
ATOM   935  O O   . THR A 1 117 ? -24.36967  -35.44248 -106.23004 1.000 23.31597 ? 117 THR A O   1 
ATOM   936  C CB  . THR A 1 117 ? -21.19082  -34.70622 -107.12280 1.000 26.93704 ? 117 THR A CB  1 
ATOM   937  O OG1 . THR A 1 117 ? -20.04020  -35.22130 -107.82497 1.000 21.45625 ? 117 THR A OG1 1 
ATOM   938  C CG2 . THR A 1 117 ? -21.04729  -34.96133 -105.61393 1.000 16.33093 ? 117 THR A CG2 1 
ATOM   939  N N   . VAL A 1 118 ? -24.12565  -33.59427 -107.48553 1.000 22.64773 ? 118 VAL A N   1 
ATOM   940  C CA  . VAL A 1 118 ? -25.31586  -32.97135 -106.91680 1.000 23.34504 ? 118 VAL A CA  1 
ATOM   941  C C   . VAL A 1 118 ? -26.57285  -33.76482 -107.28403 1.000 22.15789 ? 118 VAL A C   1 
ATOM   942  O O   . VAL A 1 118 ? -27.38096  -34.10483 -106.41139 1.000 21.21413 ? 118 VAL A O   1 
ATOM   943  C CB  . VAL A 1 118 ? -25.40738  -31.50177 -107.36500 1.000 22.92944 ? 118 VAL A CB  1 
ATOM   944  C CG1 . VAL A 1 118 ? -26.77194  -30.89429 -106.98495 1.000 18.20321 ? 118 VAL A CG1 1 
ATOM   945  C CG2 . VAL A 1 118 ? -24.26189  -30.70771 -106.75763 1.000 21.19103 ? 118 VAL A CG2 1 
ATOM   946  N N   . VAL A 1 119 ? -26.74448  -34.10083 -108.56860 1.000 19.49889 ? 119 VAL A N   1 
ATOM   947  C CA  . VAL A 1 119 ? -28.00184  -34.71285 -109.00014 1.000 23.62450 ? 119 VAL A CA  1 
ATOM   948  C C   . VAL A 1 119 ? -28.13819  -36.13757 -108.47095 1.000 22.85092 ? 119 VAL A C   1 
ATOM   949  O O   . VAL A 1 119 ? -29.23391  -36.56284 -108.08741 1.000 26.32066 ? 119 VAL A O   1 
ATOM   950  C CB  . VAL A 1 119 ? -28.13415  -34.66654 -110.53567 1.000 24.69318 ? 119 VAL A CB  1 
ATOM   951  C CG1 . VAL A 1 119 ? -29.36382  -35.45696 -111.00131 1.000 14.88340 ? 119 VAL A CG1 1 
ATOM   952  C CG2 . VAL A 1 119 ? -28.23463  -33.23569 -111.01233 1.000 21.06922 ? 119 VAL A CG2 1 
ATOM   953  N N   A ARG A 1 120 ? -27.04132  -36.90411 -108.45455 0.517 25.33769 ? 120 ARG A N   1 
ATOM   954  N N   B ARG A 1 120 ? -27.04150  -36.89896 -108.43365 0.483 25.85359 ? 120 ARG A N   1 
ATOM   955  C CA  A ARG A 1 120 ? -27.12023  -38.27544 -107.95133 0.517 25.94590 ? 120 ARG A CA  1 
ATOM   956  C CA  B ARG A 1 120 ? -27.14751  -38.27830 -107.96141 0.483 25.95916 ? 120 ARG A CA  1 
ATOM   957  C C   A ARG A 1 120 ? -27.48444  -38.31354 -106.47652 0.517 24.07283 ? 120 ARG A C   1 
ATOM   958  C C   B ARG A 1 120 ? -27.43839  -38.34539 -106.46658 0.483 25.46100 ? 120 ARG A C   1 
ATOM   959  O O   A ARG A 1 120 ? -28.20271  -39.22068 -106.04197 0.517 25.09638 ? 120 ARG A O   1 
ATOM   960  O O   B ARG A 1 120 ? -28.07350  -39.30107 -106.00730 0.483 25.14687 ? 120 ARG A O   1 
ATOM   961  C CB  A ARG A 1 120 ? -25.80150  -39.01866 -108.17457 0.517 29.09483 ? 120 ARG A CB  1 
ATOM   962  C CB  B ARG A 1 120 ? -25.87848  -39.06427 -108.30545 0.483 29.15712 ? 120 ARG A CB  1 
ATOM   963  C CG  A ARG A 1 120 ? -25.62490  -39.55916 -109.58814 0.517 33.34876 ? 120 ARG A CG  1 
ATOM   964  C CG  B ARG A 1 120 ? -25.76616  -39.42700 -109.79912 0.483 32.94528 ? 120 ARG A CG  1 
ATOM   965  C CD  A ARG A 1 120 ? -24.58253  -40.66720 -109.62013 0.517 36.24845 ? 120 ARG A CD  1 
ATOM   966  C CD  B ARG A 1 120 ? -24.57251  -40.34427 -110.07669 0.483 35.21483 ? 120 ARG A CD  1 
ATOM   967  N NE  A ARG A 1 120 ? -24.99635  -41.81362 -108.81428 0.517 36.77274 ? 120 ARG A NE  1 
ATOM   968  N NE  B ARG A 1 120 ? -24.33492  -40.58196 -111.50332 0.483 35.41449 ? 120 ARG A NE  1 
ATOM   969  C CZ  A ARG A 1 120 ? -25.79188  -42.78595 -109.25530 0.517 38.97578 ? 120 ARG A CZ  1 
ATOM   970  C CZ  B ARG A 1 120 ? -25.06957  -41.38342 -112.27192 0.483 34.14337 ? 120 ARG A CZ  1 
ATOM   971  N NH1 A ARG A 1 120 ? -26.25321  -42.75736 -110.49692 0.517 38.72864 ? 120 ARG A NH1 1 
ATOM   972  N NH1 B ARG A 1 120 ? -26.11369  -42.02874 -111.76786 0.483 34.31918 ? 120 ARG A NH1 1 
ATOM   973  N NH2 A ARG A 1 120 ? -26.12435  -43.79066 -108.45783 0.517 40.04299 ? 120 ARG A NH2 1 
ATOM   974  N NH2 B ARG A 1 120 ? -24.75958  -41.53059 -113.55396 0.483 29.67641 ? 120 ARG A NH2 1 
ATOM   975  N N   . ARG A 1 121 ? -27.01016  -37.34276 -105.69195 1.000 23.95318 ? 121 ARG A N   1 
ATOM   976  C CA  . ARG A 1 121 ? -27.30848  -37.35802 -104.25977 1.000 27.51258 ? 121 ARG A CA  1 
ATOM   977  C C   . ARG A 1 121 ? -28.81456  -37.29693 -103.99566 1.000 26.47853 ? 121 ARG A C   1 
ATOM   978  O O   . ARG A 1 121 ? -29.32650  -37.99809 -103.11505 1.000 28.69774 ? 121 ARG A O   1 
ATOM   979  C CB  . ARG A 1 121 ? -26.59898  -36.20932 -103.54553 1.000 19.95153 ? 121 ARG A CB  1 
ATOM   980  C CG  . ARG A 1 121 ? -26.87878  -36.20244 -102.04479 1.000 17.90900 ? 121 ARG A CG  1 
ATOM   981  C CD  . ARG A 1 121 ? -26.01028  -35.17142 -101.36179 1.000 24.97733 ? 121 ARG A CD  1 
ATOM   982  N NE  . ARG A 1 121 ? -26.11428  -35.18782 -99.90893  1.000 17.46045 ? 121 ARG A NE  1 
ATOM   983  C CZ  . ARG A 1 121 ? -25.49402  -36.05428 -99.11711  1.000 27.01981 ? 121 ARG A CZ  1 
ATOM   984  N NH1 . ARG A 1 121 ? -24.71498  -36.98991 -99.64596  1.000 24.58859 ? 121 ARG A NH1 1 
ATOM   985  N NH2 . ARG A 1 121 ? -25.64430  -35.97418 -97.79146  1.000 21.38297 ? 121 ARG A NH2 1 
ATOM   986  N N   . TYR A 1 122 ? -29.54273  -36.47386 -104.75512 1.000 25.37996 ? 122 TYR A N   1 
ATOM   987  C CA  . TYR A 1 122 ? -30.95024  -36.22054 -104.49849 1.000 22.54982 ? 122 TYR A CA  1 
ATOM   988  C C   . TYR A 1 122 ? -31.85863  -36.92652 -105.49262 1.000 30.38391 ? 122 TYR A C   1 
ATOM   989  O O   . TYR A 1 122 ? -33.05844  -36.63087 -105.56518 1.000 37.24410 ? 122 TYR A O   1 
ATOM   990  C CB  . TYR A 1 122 ? -31.19785  -34.71850 -104.48514 1.000 25.17261 ? 122 TYR A CB  1 
ATOM   991  C CG  . TYR A 1 122 ? -30.39279  -34.01844 -103.42853 1.000 23.71878 ? 122 TYR A CG  1 
ATOM   992  C CD1 . TYR A 1 122 ? -30.67858  -34.21289 -102.07754 1.000 22.78953 ? 122 TYR A CD1 1 
ATOM   993  C CD2 . TYR A 1 122 ? -29.36667  -33.13683 -103.76767 1.000 22.78929 ? 122 TYR A CD2 1 
ATOM   994  C CE1 . TYR A 1 122 ? -29.93601  -33.55770 -101.08695 1.000 23.70373 ? 122 TYR A CE1 1 
ATOM   995  C CE2 . TYR A 1 122 ? -28.62082  -32.47746 -102.78232 1.000 19.14340 ? 122 TYR A CE2 1 
ATOM   996  C CZ  . TYR A 1 122 ? -28.91550  -32.69423 -101.44895 1.000 24.00279 ? 122 TYR A CZ  1 
ATOM   997  O OH  . TYR A 1 122 ? -28.19420  -32.04179 -100.47627 1.000 25.46516 ? 122 TYR A OH  1 
ATOM   998  N N   . LYS A 1 123 ? -31.30470  -37.87542 -106.23984 1.000 30.11653 ? 123 LYS A N   1 
ATOM   999  C CA  . LYS A 1 123 ? -32.07318  -38.64731 -107.19685 1.000 26.97698 ? 123 LYS A CA  1 
ATOM   1000 C C   . LYS A 1 123 ? -33.20802  -39.38891 -106.49174 1.000 29.81317 ? 123 LYS A C   1 
ATOM   1001 O O   . LYS A 1 123 ? -32.99928  -40.00334 -105.44182 1.000 33.15838 ? 123 LYS A O   1 
ATOM   1002 C CB  . LYS A 1 123 ? -31.12876  -39.62165 -107.90088 1.000 27.17716 ? 123 LYS A CB  1 
ATOM   1003 C CG  . LYS A 1 123 ? -31.80643  -40.36198 -108.97796 1.000 35.84458 ? 123 LYS A CG  1 
ATOM   1004 C CD  . LYS A 1 123 ? -31.30925  -41.77384 -109.21454 1.000 47.57223 ? 123 LYS A CD  1 
ATOM   1005 C CE  . LYS A 1 123 ? -30.09958  -41.83116 -110.11176 1.000 45.61852 ? 123 LYS A CE  1 
ATOM   1006 N NZ  . LYS A 1 123 ? -30.49717  -42.53722 -111.40988 1.000 54.28018 ? 123 LYS A NZ  1 
ATOM   1007 N N   . GLY A 1 124 ? -34.42263  -39.32749 -107.05573 1.000 32.04834 ? 124 GLY A N   1 
ATOM   1008 C CA  . GLY A 1 124 ? -35.57864  -39.94244 -106.44049 1.000 31.21529 ? 124 GLY A CA  1 
ATOM   1009 C C   . GLY A 1 124 ? -36.20003  -39.16638 -105.29386 1.000 32.85400 ? 124 GLY A C   1 
ATOM   1010 O O   . GLY A 1 124 ? -37.26613  -39.55485 -104.80568 1.000 47.76268 ? 124 GLY A O   1 
ATOM   1011 N N   . LYS A 1 125 ? -35.55097  -38.10609 -104.81945 1.000 33.30389 ? 125 LYS A N   1 
ATOM   1012 C CA  . LYS A 1 125 ? -36.20108  -37.14842 -103.93707 1.000 30.94440 ? 125 LYS A CA  1 
ATOM   1013 C C   . LYS A 1 125 ? -36.53981  -35.84269 -104.63065 1.000 27.80588 ? 125 LYS A C   1 
ATOM   1014 O O   . LYS A 1 125 ? -37.54440  -35.22168 -104.29155 1.000 27.03633 ? 125 LYS A O   1 
ATOM   1015 C CB  . LYS A 1 125 ? -35.32131  -36.86384 -102.71361 1.000 31.31096 ? 125 LYS A CB  1 
ATOM   1016 C CG  . LYS A 1 125 ? -34.88419  -38.14353 -102.02697 1.000 36.49534 ? 125 LYS A CG  1 
ATOM   1017 C CD  . LYS A 1 125 ? -34.09363  -37.88589 -100.76804 1.000 42.16094 ? 125 LYS A CD  1 
ATOM   1018 C CE  . LYS A 1 125 ? -33.16907  -39.05443 -100.46998 1.000 41.51181 ? 125 LYS A CE  1 
ATOM   1019 N NZ  . LYS A 1 125 ? -32.16176  -38.66541 -99.46226  1.000 48.25969 ? 125 LYS A NZ  1 
ATOM   1020 N N   . ILE A 1 126 ? -35.75084  -35.44760 -105.62584 1.000 26.64527 ? 126 ILE A N   1 
ATOM   1021 C CA  . ILE A 1 126 ? -35.94065  -34.21159 -106.36934 1.000 23.08428 ? 126 ILE A CA  1 
ATOM   1022 C C   . ILE A 1 126 ? -36.41366  -34.58186 -107.76609 1.000 23.50482 ? 126 ILE A C   1 
ATOM   1023 O O   . ILE A 1 126 ? -35.70497  -35.27373 -108.50930 1.000 25.66225 ? 126 ILE A O   1 
ATOM   1024 C CB  . ILE A 1 126 ? -34.65090  -33.37585 -106.40897 1.000 21.09013 ? 126 ILE A CB  1 
ATOM   1025 C CG1 . ILE A 1 126 ? -34.35393  -32.78215 -105.02971 1.000 19.69608 ? 126 ILE A CG1 1 
ATOM   1026 C CG2 . ILE A 1 126 ? -34.74738  -32.27531 -107.43547 1.000 22.63636 ? 126 ILE A CG2 1 
ATOM   1027 C CD1 . ILE A 1 126 ? -33.14871  -31.80624 -105.02625 1.000 19.55892 ? 126 ILE A CD1 1 
ATOM   1028 N N   . TYR A 1 127 ? -37.61197  -34.12178 -108.13191 1.000 28.36908 ? 127 TYR A N   1 
ATOM   1029 C CA  . TYR A 1 127 ? -38.19223  -34.55165 -109.39354 1.000 22.35553 ? 127 TYR A CA  1 
ATOM   1030 C C   . TYR A 1 127 ? -37.84011  -33.64862 -110.56412 1.000 23.69766 ? 127 TYR A C   1 
ATOM   1031 O O   . TYR A 1 127 ? -38.02120  -34.06226 -111.71646 1.000 21.68728 ? 127 TYR A O   1 
ATOM   1032 C CB  . TYR A 1 127 ? -39.70766  -34.71000 -109.24994 1.000 25.19428 ? 127 TYR A CB  1 
ATOM   1033 C CG  . TYR A 1 127 ? -40.56209  -33.47221 -109.39848 1.000 23.29202 ? 127 TYR A CG  1 
ATOM   1034 C CD1 . TYR A 1 127 ? -40.56436  -32.47468 -108.41834 1.000 23.73056 ? 127 TYR A CD1 1 
ATOM   1035 C CD2 . TYR A 1 127 ? -41.42720  -33.32852 -110.49866 1.000 28.02333 ? 127 TYR A CD2 1 
ATOM   1036 C CE1 . TYR A 1 127 ? -41.38851  -31.33710 -108.54408 1.000 25.87496 ? 127 TYR A CE1 1 
ATOM   1037 C CE2 . TYR A 1 127 ? -42.26596  -32.20359 -110.63599 1.000 26.36770 ? 127 TYR A CE2 1 
ATOM   1038 C CZ  . TYR A 1 127 ? -42.24546  -31.21716 -109.65767 1.000 29.19652 ? 127 TYR A CZ  1 
ATOM   1039 O OH  . TYR A 1 127 ? -43.05599  -30.11491 -109.79061 1.000 23.69448 ? 127 TYR A OH  1 
ATOM   1040 N N   . CYS A 1 128 ? -37.29649  -32.46081 -110.32043 1.000 20.76485 ? 128 CYS A N   1 
ATOM   1041 C CA  . CYS A 1 128 ? -36.86289  -31.66375 -111.45402 1.000 23.25440 ? 128 CYS A CA  1 
ATOM   1042 C C   . CYS A 1 128 ? -35.78608  -30.67926 -111.01276 1.000 22.50872 ? 128 CYS A C   1 
ATOM   1043 O O   . CYS A 1 128 ? -35.61650  -30.38663 -109.82840 1.000 22.61876 ? 128 CYS A O   1 
ATOM   1044 C CB  . CYS A 1 128 ? -38.05068  -30.94235 -112.09125 1.000 19.31387 ? 128 CYS A CB  1 
ATOM   1045 S SG  . CYS A 1 128 ? -38.68096  -29.74474 -110.89322 1.000 24.78627 ? 128 CYS A SG  1 
ATOM   1046 N N   . TRP A 1 129 ? -35.05650  -30.18772 -112.00628 1.000 23.72501 ? 129 TRP A N   1 
ATOM   1047 C CA  . TRP A 1 129 ? -33.85868  -29.37384 -111.83098 1.000 22.74409 ? 129 TRP A CA  1 
ATOM   1048 C C   . TRP A 1 129 ? -33.89950  -28.20838 -112.80673 1.000 26.60204 ? 129 TRP A C   1 
ATOM   1049 O O   . TRP A 1 129 ? -34.17179  -28.39083 -114.00267 1.000 20.89540 ? 129 TRP A O   1 
ATOM   1050 C CB  . TRP A 1 129 ? -32.57434  -30.19168 -112.08503 1.000 22.11282 ? 129 TRP A CB  1 
ATOM   1051 C CG  . TRP A 1 129 ? -32.04105  -30.82068 -110.84747 1.000 22.67224 ? 129 TRP A CG  1 
ATOM   1052 C CD1 . TRP A 1 129 ? -32.17508  -32.13129 -110.45851 1.000 18.52644 ? 129 TRP A CD1 1 
ATOM   1053 C CD2 . TRP A 1 129 ? -31.32347  -30.15935 -109.79979 1.000 21.97805 ? 129 TRP A CD2 1 
ATOM   1054 N NE1 . TRP A 1 129 ? -31.56693  -32.31969 -109.23814 1.000 22.06633 ? 129 TRP A NE1 1 
ATOM   1055 C CE2 . TRP A 1 129 ? -31.04529  -31.12729 -108.80733 1.000 20.96518 ? 129 TRP A CE2 1 
ATOM   1056 C CE3 . TRP A 1 129 ? -30.89263  -28.83928 -109.59898 1.000 20.27005 ? 129 TRP A CE3 1 
ATOM   1057 C CZ2 . TRP A 1 129 ? -30.35210  -30.81751 -107.63372 1.000 21.60358 ? 129 TRP A CZ2 1 
ATOM   1058 C CZ3 . TRP A 1 129 ? -30.19873  -28.53228 -108.42668 1.000 20.48478 ? 129 TRP A CZ3 1 
ATOM   1059 C CH2 . TRP A 1 129 ? -29.93570  -29.51941 -107.46477 1.000 24.95533 ? 129 TRP A CH2 1 
ATOM   1060 N N   . ASP A 1 130 ? -33.65174  -27.00964 -112.28997 1.000 20.74140 ? 130 ASP A N   1 
ATOM   1061 C CA  . ASP A 1 130 ? -33.29842  -25.90243 -113.16317 1.000 18.62043 ? 130 ASP A CA  1 
ATOM   1062 C C   . ASP A 1 130 ? -31.84984  -26.11752 -113.58407 1.000 25.76853 ? 130 ASP A C   1 
ATOM   1063 O O   . ASP A 1 130 ? -30.91358  -25.74813 -112.85903 1.000 21.96764 ? 130 ASP A O   1 
ATOM   1064 C CB  . ASP A 1 130 ? -33.48101  -24.56095 -112.45401 1.000 23.22951 ? 130 ASP A CB  1 
ATOM   1065 C CG  . ASP A 1 130 ? -34.92100  -24.29808 -112.05550 1.000 26.48468 ? 130 ASP A CG  1 
ATOM   1066 O OD1 . ASP A 1 130 ? -35.84731  -24.86880 -112.69534 1.000 17.08799 ? 130 ASP A OD1 1 
ATOM   1067 O OD2 . ASP A 1 130 ? -35.11270  -23.50967 -111.09829 1.000 22.26271 ? 130 ASP A OD2 1 
ATOM   1068 N N   . VAL A 1 131 ? -31.65656  -26.77786 -114.72386 1.000 25.83259 ? 131 VAL A N   1 
ATOM   1069 C CA  . VAL A 1 131 ? -30.30452  -27.07760 -115.17231 1.000 24.39597 ? 131 VAL A CA  1 
ATOM   1070 C C   . VAL A 1 131 ? -29.58058  -25.78906 -115.54471 1.000 24.69227 ? 131 VAL A C   1 
ATOM   1071 O O   . VAL A 1 131 ? -28.52306  -25.47522 -114.99208 1.000 23.73988 ? 131 VAL A O   1 
ATOM   1072 C CB  . VAL A 1 131 ? -30.33569  -28.08586 -116.33437 1.000 23.27472 ? 131 VAL A CB  1 
ATOM   1073 C CG1 . VAL A 1 131 ? -28.93850  -28.30904 -116.87118 1.000 19.04718 ? 131 VAL A CG1 1 
ATOM   1074 C CG2 . VAL A 1 131 ? -30.93999  -29.39839 -115.86114 1.000 20.01519 ? 131 VAL A CG2 1 
ATOM   1075 N N   . ILE A 1 132 ? -30.16711  -25.00433 -116.44977 1.000 22.96438 ? 132 ILE A N   1 
ATOM   1076 C CA  . ILE A 1 132 ? -29.59974  -23.74433 -116.91757 1.000 23.14685 ? 132 ILE A CA  1 
ATOM   1077 C C   . ILE A 1 132 ? -30.47561  -22.61418 -116.38698 1.000 25.05122 ? 132 ILE A C   1 
ATOM   1078 O O   . ILE A 1 132 ? -31.70969  -22.68479 -116.46652 1.000 20.57673 ? 132 ILE A O   1 
ATOM   1079 C CB  . ILE A 1 132 ? -29.50462  -23.71035 -118.45727 1.000 28.06849 ? 132 ILE A CB  1 
ATOM   1080 C CG1 . ILE A 1 132 ? -28.57887  -24.81749 -118.95974 1.000 21.73400 ? 132 ILE A CG1 1 
ATOM   1081 C CG2 . ILE A 1 132 ? -29.00577  -22.35649 -118.95572 1.000 22.59834 ? 132 ILE A CG2 1 
ATOM   1082 C CD1 . ILE A 1 132 ? -27.08058  -24.53736 -118.66927 1.000 25.73913 ? 132 ILE A CD1 1 
ATOM   1083 N N   . ASN A 1 133 ? -29.84415  -21.58003 -115.84096 1.000 19.04278 ? 133 ASN A N   1 
ATOM   1084 C CA  . ASN A 1 133 ? -30.55651  -20.44835 -115.26308 1.000 22.64964 ? 133 ASN A CA  1 
ATOM   1085 C C   . ASN A 1 133 ? -30.12064  -19.17768 -115.98085 1.000 23.45958 ? 133 ASN A C   1 
ATOM   1086 O O   . ASN A 1 133 ? -28.93003  -18.84023 -115.99228 1.000 22.25937 ? 133 ASN A O   1 
ATOM   1087 C CB  . ASN A 1 133 ? -30.30271  -20.34528 -113.74705 1.000 22.60944 ? 133 ASN A CB  1 
ATOM   1088 C CG  . ASN A 1 133 ? -31.39060  -19.55202 -113.00791 1.000 24.94424 ? 133 ASN A CG  1 
ATOM   1089 O OD1 . ASN A 1 133 ? -32.58839  -19.73287 -113.24229 1.000 26.04988 ? 133 ASN A OD1 1 
ATOM   1090 N ND2 . ASN A 1 133 ? -30.96806  -18.68134 -112.10554 1.000 22.74596 ? 133 ASN A ND2 1 
ATOM   1091 N N   . GLU A 1 134 ? -31.07951  -18.50586 -116.62199 1.000 28.59018 ? 134 GLU A N   1 
ATOM   1092 C CA  . GLU A 1 134 ? -30.90892  -17.11983 -117.06420 1.000 26.68580 ? 134 GLU A CA  1 
ATOM   1093 C C   . GLU A 1 134 ? -29.80136  -16.96187 -118.10883 1.000 23.25072 ? 134 GLU A C   1 
ATOM   1094 O O   . GLU A 1 134 ? -29.07967  -15.96476 -118.11367 1.000 31.44672 ? 134 GLU A O   1 
ATOM   1095 C CB  . GLU A 1 134 ? -30.64167  -16.20915 -115.86494 1.000 19.92083 ? 134 GLU A CB  1 
ATOM   1096 C CG  . GLU A 1 134 ? -31.79490  -16.11638 -114.91489 1.000 23.92631 ? 134 GLU A CG  1 
ATOM   1097 C CD  . GLU A 1 134 ? -31.43517  -15.34279 -113.66129 1.000 26.13202 ? 134 GLU A CD  1 
ATOM   1098 O OE1 . GLU A 1 134 ? -30.34089  -14.74724 -113.62719 1.000 26.18050 ? 134 GLU A OE1 1 
ATOM   1099 O OE2 . GLU A 1 134 ? -32.24363  -15.34102 -112.71139 1.000 31.32927 ? 134 GLU A OE2 1 
ATOM   1100 N N   . ALA A 1 135 ? -29.68075  -17.92991 -119.02409 1.000 24.75414 ? 135 ALA A N   1 
ATOM   1101 C CA  . ALA A 1 135 ? -28.62740  -17.85198 -120.03737 1.000 31.08775 ? 135 ALA A CA  1 
ATOM   1102 C C   . ALA A 1 135 ? -28.94133  -16.82993 -121.12690 1.000 32.43248 ? 135 ALA A C   1 
ATOM   1103 O O   . ALA A 1 135 ? -28.01809  -16.33120 -121.78534 1.000 31.13477 ? 135 ALA A O   1 
ATOM   1104 C CB  . ALA A 1 135 ? -28.39149  -19.22353 -120.67470 1.000 30.40542 ? 135 ALA A CB  1 
ATOM   1105 N N   . VAL A 1 136 ? -30.22388  -16.53240 -121.35410 1.000 26.68333 ? 136 VAL A N   1 
ATOM   1106 C CA  . VAL A 1 136 ? -30.60877  -15.59049 -122.40023 1.000 30.77938 ? 136 VAL A CA  1 
ATOM   1107 C C   . VAL A 1 136 ? -30.29811  -14.16910 -121.94034 1.000 30.57196 ? 136 VAL A C   1 
ATOM   1108 O O   . VAL A 1 136 ? -30.40200  -13.85038 -120.74792 1.000 30.10312 ? 136 VAL A O   1 
ATOM   1109 C CB  . VAL A 1 136 ? -32.10241  -15.76745 -122.72908 1.000 25.44392 ? 136 VAL A CB  1 
ATOM   1110 C CG1 . VAL A 1 136 ? -32.63340  -14.59239 -123.52418 1.000 23.92000 ? 136 VAL A CG1 1 
ATOM   1111 C CG2 . VAL A 1 136 ? -32.33589  -17.08308 -123.46583 1.000 27.16938 ? 136 VAL A CG2 1 
ATOM   1112 N N   . ALA A 1 137 ? -29.90066  -13.30457 -122.87622 1.000 34.17460 ? 137 ALA A N   1 
ATOM   1113 C CA  . ALA A 1 137 ? -29.65973  -11.90556 -122.53227 1.000 41.15681 ? 137 ALA A CA  1 
ATOM   1114 C C   . ALA A 1 137 ? -30.96149  -11.20799 -122.15368 1.000 35.72020 ? 137 ALA A C   1 
ATOM   1115 O O   . ALA A 1 137 ? -31.99337  -11.41458 -122.79485 1.000 32.78606 ? 137 ALA A O   1 
ATOM   1116 C CB  . ALA A 1 137 ? -29.00530  -11.17121 -123.69837 1.000 34.51074 ? 137 ALA A CB  1 
ATOM   1117 N N   . ASP A 1 138 ? -30.90081  -10.36752 -121.10831 1.000 35.05131 ? 138 ASP A N   1 
ATOM   1118 C CA  . ASP A 1 138 ? -32.02894  -9.56369  -120.63359 1.000 42.83850 ? 138 ASP A CA  1 
ATOM   1119 C C   . ASP A 1 138 ? -32.13378  -8.21338  -121.33541 1.000 47.04601 ? 138 ASP A C   1 
ATOM   1120 O O   . ASP A 1 138 ? -33.12424  -7.50360  -121.13300 1.000 47.95852 ? 138 ASP A O   1 
ATOM   1121 C CB  . ASP A 1 138 ? -31.92458  -9.33045  -119.10811 1.000 36.46288 ? 138 ASP A CB  1 
ATOM   1122 C CG  . ASP A 1 138 ? -33.23525  -8.82998  -118.48646 1.000 33.11601 ? 138 ASP A CG  1 
ATOM   1123 O OD1 . ASP A 1 138 ? -34.28534  -9.44617  -118.73923 1.000 31.27369 ? 138 ASP A OD1 1 
ATOM   1124 O OD2 . ASP A 1 138 ? -33.21665  -7.83286  -117.72993 1.000 44.66652 ? 138 ASP A OD2 1 
ATOM   1125 N N   . GLU A 1 139 ? -31.14073  -7.84775  -122.14646 1.000 53.39200 ? 139 GLU A N   1 
ATOM   1126 C CA  . GLU A 1 139 ? -31.09917  -6.57661  -122.85954 1.000 55.03292 ? 139 GLU A CA  1 
ATOM   1127 C C   . GLU A 1 139 ? -30.25847  -6.75003  -124.11972 1.000 57.24856 ? 139 GLU A C   1 
ATOM   1128 O O   . GLU A 1 139 ? -29.39539  -7.62720  -124.18817 1.000 57.70962 ? 139 GLU A O   1 
ATOM   1129 C CB  . GLU A 1 139 ? -30.50811  -5.46993  -121.97619 1.000 60.66852 ? 139 GLU A CB  1 
ATOM   1130 C CG  . GLU A 1 139 ? -29.09032  -5.78916  -121.49412 1.000 64.55895 ? 139 GLU A CG  1 
ATOM   1131 C CD  . GLU A 1 139 ? -28.50021  -4.71339  -120.59232 1.000 82.83468 ? 139 GLU A CD  1 
ATOM   1132 O OE1 . GLU A 1 139 ? -28.54268  -3.52294  -120.97417 1.000 94.09383 ? 139 GLU A OE1 1 
ATOM   1133 O OE2 . GLU A 1 139 ? -27.99076  -5.06341  -119.50028 1.000 80.22218 ? 139 GLU A OE2 1 
ATOM   1134 N N   . GLY A 1 140 ? -30.50482  -5.90017  -125.10546 1.000 63.21671 ? 140 GLY A N   1 
ATOM   1135 C CA  . GLY A 1 140 ? -29.69268  -5.90358  -126.30403 1.000 53.20738 ? 140 GLY A CA  1 
ATOM   1136 C C   . GLY A 1 140 ? -30.28491  -6.77058  -127.38809 1.000 55.64962 ? 140 GLY A C   1 
ATOM   1137 O O   . GLY A 1 140 ? -31.39253  -7.30598  -127.27689 1.000 62.04603 ? 140 GLY A O   1 
ATOM   1138 N N   . ASN A 1 141 ? -29.51901  -6.91032  -128.46872 1.000 59.71225 ? 141 ASN A N   1 
ATOM   1139 C CA  . ASN A 1 141 ? -29.93754  -7.72880  -129.59857 1.000 61.61495 ? 141 ASN A CA  1 
ATOM   1140 C C   . ASN A 1 141 ? -29.37314  -9.13762  -129.54895 1.000 56.57688 ? 141 ASN A C   1 
ATOM   1141 O O   . ASN A 1 141 ? -29.80873  -9.99114  -130.32906 1.000 57.70066 ? 141 ASN A O   1 
ATOM   1142 C CB  . ASN A 1 141 ? -29.53500  -7.07056  -130.92646 1.000 67.59746 ? 141 ASN A CB  1 
ATOM   1143 C CG  . ASN A 1 141 ? -29.89420  -5.60036  -130.98193 1.000 77.55804 ? 141 ASN A CG  1 
ATOM   1144 O OD1 . ASN A 1 141 ? -30.98522  -5.20127  -130.56099 1.000 75.40806 ? 141 ASN A OD1 1 
ATOM   1145 N ND2 . ASN A 1 141 ? -28.98615  -4.78583  -131.52110 1.000 75.94079 ? 141 ASN A ND2 1 
ATOM   1146 N N   . GLU A 1 142 ? -28.42708  -9.40184  -128.65655 1.000 49.18278 ? 142 GLU A N   1 
ATOM   1147 C CA  . GLU A 1 142 ? -27.83898  -10.72748 -128.57729 1.000 54.35247 ? 142 GLU A CA  1 
ATOM   1148 C C   . GLU A 1 142 ? -28.83792  -11.73256 -128.01822 1.000 49.01681 ? 142 GLU A C   1 
ATOM   1149 O O   . GLU A 1 142 ? -29.79281  -11.37758 -127.32303 1.000 52.57477 ? 142 GLU A O   1 
ATOM   1150 C CB  . GLU A 1 142 ? -26.59342  -10.70126 -127.70746 1.000 51.31002 ? 142 GLU A CB  1 
ATOM   1151 C CG  . GLU A 1 142 ? -25.45255  -9.96222  -128.34360 1.000 59.91972 ? 142 GLU A CG  1 
ATOM   1152 C CD  . GLU A 1 142 ? -24.31709  -10.89807 -128.68660 1.000 78.19462 ? 142 GLU A CD  1 
ATOM   1153 O OE1 . GLU A 1 142 ? -23.42611  -11.10574 -127.82605 1.000 81.99162 ? 142 GLU A OE1 1 
ATOM   1154 O OE2 . GLU A 1 142 ? -24.32480  -11.43425 -129.81797 1.000 80.96316 ? 142 GLU A OE2 1 
ATOM   1155 N N   . LEU A 1 143 ? -28.61325  -13.01107 -128.33418 1.000 45.02068 ? 143 LEU A N   1 
ATOM   1156 C CA  . LEU A 1 143 ? -29.47216  -14.03343 -127.75430 1.000 39.00125 ? 143 LEU A CA  1 
ATOM   1157 C C   . LEU A 1 143 ? -29.00101  -14.41595 -126.35645 1.000 41.46904 ? 143 LEU A C   1 
ATOM   1158 O O   . LEU A 1 143 ? -29.81474  -14.54479 -125.43738 1.000 41.09682 ? 143 LEU A O   1 
ATOM   1159 C CB  . LEU A 1 143 ? -29.54839  -15.25985 -128.66681 1.000 42.39549 ? 143 LEU A CB  1 
ATOM   1160 C CG  . LEU A 1 143 ? -30.47771  -16.35185 -128.11538 1.000 39.78545 ? 143 LEU A CG  1 
ATOM   1161 C CD1 . LEU A 1 143 ? -31.84785  -16.33916 -128.75332 1.000 38.05973 ? 143 LEU A CD1 1 
ATOM   1162 C CD2 . LEU A 1 143 ? -29.85210  -17.70247 -128.32583 1.000 42.33420 ? 143 LEU A CD2 1 
ATOM   1163 N N   . LEU A 1 144 ? -27.69419  -14.53870 -126.16600 1.000 40.38173 ? 144 LEU A N   1 
ATOM   1164 C CA  . LEU A 1 144 ? -27.12461  -15.10368 -124.95502 1.000 39.07334 ? 144 LEU A CA  1 
ATOM   1165 C C   . LEU A 1 144 ? -26.40065  -14.03112 -124.16251 1.000 41.74039 ? 144 LEU A C   1 
ATOM   1166 O O   . LEU A 1 144 ? -25.61488  -13.25354 -124.71336 1.000 41.89333 ? 144 LEU A O   1 
ATOM   1167 C CB  . LEU A 1 144 ? -26.15618  -16.24945 -125.26340 1.000 27.32287 ? 144 LEU A CB  1 
ATOM   1168 C CG  . LEU A 1 144 ? -26.78689  -17.52195 -125.85107 1.000 33.69756 ? 144 LEU A CG  1 
ATOM   1169 C CD1 . LEU A 1 144 ? -25.72452  -18.60381 -125.95888 1.000 32.95840 ? 144 LEU A CD1 1 
ATOM   1170 C CD2 . LEU A 1 144 ? -28.01242  -18.02079 -125.07031 1.000 31.19774 ? 144 LEU A CD2 1 
ATOM   1171 N N   . ARG A 1 145 ? -26.68982  -13.99500 -122.87695 1.000 41.66533 ? 145 ARG A N   1 
ATOM   1172 C CA  . ARG A 1 145 ? -25.91855  -13.20930 -121.93488 1.000 38.93296 ? 145 ARG A CA  1 
ATOM   1173 C C   . ARG A 1 145 ? -24.47417  -13.70752 -121.92776 1.000 40.95746 ? 145 ARG A C   1 
ATOM   1174 O O   . ARG A 1 145 ? -24.23504  -14.90759 -122.11094 1.000 40.09461 ? 145 ARG A O   1 
ATOM   1175 C CB  . ARG A 1 145 ? -26.57999  -13.35352 -120.56149 1.000 34.99605 ? 145 ARG A CB  1 
ATOM   1176 C CG  . ARG A 1 145 ? -25.85184  -12.84002 -119.37337 1.000 39.26803 ? 145 ARG A CG  1 
ATOM   1177 C CD  . ARG A 1 145 ? -26.46588  -13.42582 -118.10714 1.000 35.68173 ? 145 ARG A CD  1 
ATOM   1178 N NE  . ARG A 1 145 ? -27.92029  -13.24128 -117.98224 1.000 29.76378 ? 145 ARG A NE  1 
ATOM   1179 C CZ  . ARG A 1 145 ? -28.49250  -12.21534 -117.35231 1.000 29.49815 ? 145 ARG A CZ  1 
ATOM   1180 N NH1 . ARG A 1 145 ? -27.74273  -11.25659 -116.83196 1.000 33.67279 ? 145 ARG A NH1 1 
ATOM   1181 N NH2 . ARG A 1 145 ? -29.81212  -12.12471 -117.26114 1.000 32.78627 ? 145 ARG A NH2 1 
ATOM   1182 N N   . PRO A 1 146 ? -23.48655  -12.82611 -121.76326 1.000 49.13652 ? 146 PRO A N   1 
ATOM   1183 C CA  . PRO A 1 146 ? -22.11077  -13.30665 -121.58285 1.000 44.36080 ? 146 PRO A CA  1 
ATOM   1184 C C   . PRO A 1 146 ? -21.97371  -13.99312 -120.23504 1.000 47.14953 ? 146 PRO A C   1 
ATOM   1185 O O   . PRO A 1 146 ? -22.70109  -13.68874 -119.28608 1.000 48.56403 ? 146 PRO A O   1 
ATOM   1186 C CB  . PRO A 1 146 ? -21.25970  -12.02868 -121.63730 1.000 39.43698 ? 146 PRO A CB  1 
ATOM   1187 C CG  . PRO A 1 146 ? -22.19349  -10.91299 -121.99320 1.000 49.04453 ? 146 PRO A CG  1 
ATOM   1188 C CD  . PRO A 1 146 ? -23.57879  -11.36127 -121.65486 1.000 47.65969 ? 146 PRO A CD  1 
ATOM   1189 N N   . SER A 1 147 ? -21.02965  -14.92700 -120.15735 1.000 34.70290 ? 147 SER A N   1 
ATOM   1190 C CA  . SER A 1 147 ? -20.72218  -15.62442 -118.91133 1.000 36.19858 ? 147 SER A CA  1 
ATOM   1191 C C   . SER A 1 147 ? -19.48609  -16.47205 -119.14351 1.000 36.97275 ? 147 SER A C   1 
ATOM   1192 O O   . SER A 1 147 ? -19.19073  -16.86747 -120.27609 1.000 42.83747 ? 147 SER A O   1 
ATOM   1193 C CB  . SER A 1 147 ? -21.86752  -16.51758 -118.43006 1.000 30.68702 ? 147 SER A CB  1 
ATOM   1194 O OG  . SER A 1 147 ? -21.97077  -17.68369 -119.22782 1.000 31.15226 ? 147 SER A OG  1 
ATOM   1195 N N   . LYS A 1 148 ? -18.77753  -16.76551 -118.05338 1.000 35.68297 ? 148 LYS A N   1 
ATOM   1196 C CA  . LYS A 1 148 ? -17.56013  -17.55562 -118.18277 1.000 35.96912 ? 148 LYS A CA  1 
ATOM   1197 C C   . LYS A 1 148 ? -17.87634  -18.96517 -118.66738 1.000 36.54121 ? 148 LYS A C   1 
ATOM   1198 O O   . LYS A 1 148 ? -17.10861  -19.54379 -119.44240 1.000 34.98705 ? 148 LYS A O   1 
ATOM   1199 C CB  . LYS A 1 148 ? -16.80586  -17.56802 -116.85980 1.000 36.55609 ? 148 LYS A CB  1 
ATOM   1200 C CG  . LYS A 1 148 ? -16.24224  -16.19472 -116.45662 1.000 38.29994 ? 148 LYS A CG  1 
ATOM   1201 C CD  . LYS A 1 148 ? -15.99261  -16.15121 -114.95827 1.000 43.55207 ? 148 LYS A CD  1 
ATOM   1202 C CE  . LYS A 1 148 ? -15.51180  -14.79243 -114.49091 1.000 50.22879 ? 148 LYS A CE  1 
ATOM   1203 N NZ  . LYS A 1 148 ? -14.44417  -14.91405 -113.45664 1.000 57.86697 ? 148 LYS A NZ  1 
ATOM   1204 N N   . TRP A 1 149 ? -19.01388  -19.52289 -118.24234 1.000 29.88045 ? 149 TRP A N   1 
ATOM   1205 C CA  . TRP A 1 149 ? -19.48836  -20.77565 -118.81799 1.000 31.34667 ? 149 TRP A CA  1 
ATOM   1206 C C   . TRP A 1 149 ? -19.47751  -20.70150 -120.33481 1.000 33.90066 ? 149 TRP A C   1 
ATOM   1207 O O   . TRP A 1 149 ? -18.89410  -21.54994 -121.01650 1.000 32.65013 ? 149 TRP A O   1 
ATOM   1208 C CB  . TRP A 1 149 ? -20.91417  -21.09010 -118.35145 1.000 27.99966 ? 149 TRP A CB  1 
ATOM   1209 C CG  . TRP A 1 149 ? -21.09913  -21.34216 -116.89841 1.000 33.60794 ? 149 TRP A CG  1 
ATOM   1210 C CD1 . TRP A 1 149 ? -21.75466  -20.54125 -116.00655 1.000 26.33227 ? 149 TRP A CD1 1 
ATOM   1211 C CD2 . TRP A 1 149 ? -20.66488  -22.49246 -116.16517 1.000 31.69094 ? 149 TRP A CD2 1 
ATOM   1212 N NE1 . TRP A 1 149 ? -21.74729  -21.11728 -114.76081 1.000 27.64293 ? 149 TRP A NE1 1 
ATOM   1213 C CE2 . TRP A 1 149 ? -21.08681  -22.31650 -114.82638 1.000 30.54531 ? 149 TRP A CE2 1 
ATOM   1214 C CE3 . TRP A 1 149 ? -19.96042  -23.65404 -116.50731 1.000 25.04404 ? 149 TRP A CE3 1 
ATOM   1215 C CZ2 . TRP A 1 149 ? -20.81792  -23.25637 -113.82168 1.000 29.58430 ? 149 TRP A CZ2 1 
ATOM   1216 C CZ3 . TRP A 1 149 ? -19.68227  -24.58516 -115.50091 1.000 25.32739 ? 149 TRP A CZ3 1 
ATOM   1217 C CH2 . TRP A 1 149 ? -20.11741  -24.37985 -114.18037 1.000 31.47778 ? 149 TRP A CH2 1 
ATOM   1218 N N   . ARG A 1 150 ? -20.15429  -19.68344 -120.87303 1.000 39.36772 ? 150 ARG A N   1 
ATOM   1219 C CA  . ARG A 1 150 ? -20.30449  -19.54375 -122.31405 1.000 32.02584 ? 150 ARG A CA  1 
ATOM   1220 C C   . ARG A 1 150 ? -18.98572  -19.17276 -122.97639 1.000 37.33387 ? 150 ARG A C   1 
ATOM   1221 O O   . ARG A 1 150 ? -18.65202  -19.69038 -124.04884 1.000 41.67114 ? 150 ARG A O   1 
ATOM   1222 C CB  . ARG A 1 150 ? -21.36454  -18.49149 -122.60067 1.000 37.17838 ? 150 ARG A CB  1 
ATOM   1223 C CG  . ARG A 1 150 ? -21.59285  -18.23869 -124.06736 1.000 40.16343 ? 150 ARG A CG  1 
ATOM   1224 C CD  . ARG A 1 150 ? -22.37948  -16.96202 -124.26077 1.000 40.84117 ? 150 ARG A CD  1 
ATOM   1225 N NE  . ARG A 1 150 ? -22.43151  -16.57668 -125.66944 1.000 48.80067 ? 150 ARG A NE  1 
ATOM   1226 C CZ  . ARG A 1 150 ? -22.65371  -15.33758 -126.09284 1.000 43.84341 ? 150 ARG A CZ  1 
ATOM   1227 N NH1 . ARG A 1 150 ? -22.83800  -14.36181 -125.21070 1.000 45.11959 ? 150 ARG A NH1 1 
ATOM   1228 N NH2 . ARG A 1 150 ? -22.69114  -15.07475 -127.39366 1.000 50.83133 ? 150 ARG A NH2 1 
ATOM   1229 N N   . GLN A 1 151 ? -18.22257  -18.28287 -122.34226 1.000 39.60178 ? 151 GLN A N   1 
ATOM   1230 C CA  . GLN A 1 151 ? -16.96276  -17.81694 -122.91171 1.000 40.78360 ? 151 GLN A CA  1 
ATOM   1231 C C   . GLN A 1 151 ? -15.96236  -18.95855 -123.06116 1.000 40.71067 ? 151 GLN A C   1 
ATOM   1232 O O   . GLN A 1 151 ? -15.31088  -19.09709 -124.10056 1.000 36.29830 ? 151 GLN A O   1 
ATOM   1233 C CB  . GLN A 1 151 ? -16.39123  -16.70906 -122.02687 1.000 39.97426 ? 151 GLN A CB  1 
ATOM   1234 C CG  . GLN A 1 151 ? -14.93327  -16.38867 -122.29573 1.000 56.60481 ? 151 GLN A CG  1 
ATOM   1235 C CD  . GLN A 1 151 ? -14.31106  -15.54434 -121.19452 1.000 67.05851 ? 151 GLN A CD  1 
ATOM   1236 O OE1 . GLN A 1 151 ? -14.90419  -14.56256 -120.73644 1.000 63.00618 ? 151 GLN A OE1 1 
ATOM   1237 N NE2 . GLN A 1 151 ? -13.10514  -15.92144 -120.76714 1.000 61.60780 ? 151 GLN A NE2 1 
ATOM   1238 N N   . ILE A 1 152 ? -15.83788  -19.79366 -122.03045 1.000 39.78039 ? 152 ILE A N   1 
ATOM   1239 C CA  . ILE A 1 152 ? -14.83013  -20.84951 -122.01675 1.000 36.18870 ? 152 ILE A CA  1 
ATOM   1240 C C   . ILE A 1 152 ? -15.28289  -22.04923 -122.84717 1.000 41.25703 ? 152 ILE A C   1 
ATOM   1241 O O   . ILE A 1 152 ? -14.53413  -22.57251 -123.68158 1.000 40.75387 ? 152 ILE A O   1 
ATOM   1242 C CB  . ILE A 1 152 ? -14.51903  -21.24402 -120.55895 1.000 33.70271 ? 152 ILE A CB  1 
ATOM   1243 C CG1 . ILE A 1 152 ? -13.91202  -20.05469 -119.80191 1.000 37.65467 ? 152 ILE A CG1 1 
ATOM   1244 C CG2 . ILE A 1 152 ? -13.61848  -22.45337 -120.50885 1.000 32.56057 ? 152 ILE A CG2 1 
ATOM   1245 C CD1 . ILE A 1 152 ? -13.61527  -20.31894 -118.32362 1.000 36.76045 ? 152 ILE A CD1 1 
ATOM   1246 N N   . ILE A 1 153 ? -16.51295  -22.51096 -122.63830 1.000 39.13023 ? 153 ILE A N   1 
ATOM   1247 C CA  . ILE A 1 153 ? -16.93719  -23.73567 -123.30630 1.000 35.98666 ? 153 ILE A CA  1 
ATOM   1248 C C   . ILE A 1 153 ? -17.39977  -23.45367 -124.73101 1.000 36.48267 ? 153 ILE A C   1 
ATOM   1249 O O   . ILE A 1 153 ? -17.16069  -24.25431 -125.64070 1.000 40.01277 ? 153 ILE A O   1 
ATOM   1250 C CB  . ILE A 1 153 ? -18.03212  -24.43195 -122.47448 1.000 36.04744 ? 153 ILE A CB  1 
ATOM   1251 C CG1 . ILE A 1 153 ? -17.44123  -25.00236 -121.18513 1.000 35.08332 ? 153 ILE A CG1 1 
ATOM   1252 C CG2 . ILE A 1 153 ? -18.78881  -25.50520 -123.29415 1.000 26.31013 ? 153 ILE A CG2 1 
ATOM   1253 C CD1 . ILE A 1 153 ? -18.49525  -25.43044 -120.19797 1.000 34.10650 ? 153 ILE A CD1 1 
ATOM   1254 N N   . GLY A 1 154 ? -18.06688  -22.33058 -124.94917 1.000 37.98422 ? 154 GLY A N   1 
ATOM   1255 C CA  . GLY A 1 154 ? -18.76932  -22.07994 -126.19207 1.000 40.24595 ? 154 GLY A CA  1 
ATOM   1256 C C   . GLY A 1 154 ? -20.27470  -22.16320 -125.99983 1.000 38.13789 ? 154 GLY A C   1 
ATOM   1257 O O   . GLY A 1 154 ? -20.78251  -22.49455 -124.92863 1.000 39.55365 ? 154 GLY A O   1 
ATOM   1258 N N   . ASP A 1 155 ? -20.99330  -21.85062 -127.07384 1.000 36.09829 ? 155 ASP A N   1 
ATOM   1259 C CA  . ASP A 1 155 ? -22.44133  -21.72473 -126.95224 1.000 34.16337 ? 155 ASP A CA  1 
ATOM   1260 C C   . ASP A 1 155 ? -23.13894  -23.06223 -126.72807 1.000 36.46275 ? 155 ASP A C   1 
ATOM   1261 O O   . ASP A 1 155 ? -24.33565  -23.07374 -126.42692 1.000 43.13767 ? 155 ASP A O   1 
ATOM   1262 C CB  . ASP A 1 155 ? -23.03206  -21.03696 -128.19362 1.000 38.73949 ? 155 ASP A CB  1 
ATOM   1263 C CG  . ASP A 1 155 ? -22.60856  -19.57202 -128.32158 1.000 44.58601 ? 155 ASP A CG  1 
ATOM   1264 O OD1 . ASP A 1 155 ? -22.08739  -18.99568 -127.34145 1.000 44.70771 ? 155 ASP A OD1 1 
ATOM   1265 O OD2 . ASP A 1 155 ? -22.82087  -18.98165 -129.40309 1.000 57.37933 ? 155 ASP A OD2 1 
ATOM   1266 N N   . ASP A 1 156 ? -22.44018  -24.18037 -126.86184 1.000 32.84612 ? 156 ASP A N   1 
ATOM   1267 C CA  . ASP A 1 156 ? -23.03684  -25.47860 -126.60324 1.000 36.37103 ? 156 ASP A CA  1 
ATOM   1268 C C   . ASP A 1 156 ? -22.86385  -25.93027 -125.15051 1.000 34.84221 ? 156 ASP A C   1 
ATOM   1269 O O   . ASP A 1 156 ? -23.11429  -27.10285 -124.84801 1.000 34.49143 ? 156 ASP A O   1 
ATOM   1270 C CB  . ASP A 1 156 ? -22.45566  -26.51701 -127.56771 1.000 41.05098 ? 156 ASP A CB  1 
ATOM   1271 C CG  . ASP A 1 156 ? -21.02503  -26.87761 -127.23392 1.000 40.85424 ? 156 ASP A CG  1 
ATOM   1272 O OD1 . ASP A 1 156 ? -20.26401  -25.95262 -126.87573 1.000 42.36315 ? 156 ASP A OD1 1 
ATOM   1273 O OD2 . ASP A 1 156 ? -20.66030  -28.07296 -127.32865 1.000 46.03147 ? 156 ASP A OD2 1 
ATOM   1274 N N   . PHE A 1 157 ? -22.45998  -25.02944 -124.24400 1.000 28.57582 ? 157 PHE A N   1 
ATOM   1275 C CA  . PHE A 1 157 ? -22.38842  -25.39005 -122.82933 1.000 24.89872 ? 157 PHE A CA  1 
ATOM   1276 C C   . PHE A 1 157 ? -23.75379  -25.82223 -122.29802 1.000 32.33690 ? 157 PHE A C   1 
ATOM   1277 O O   . PHE A 1 157 ? -23.84472  -26.74739 -121.48598 1.000 31.56930 ? 157 PHE A O   1 
ATOM   1278 C CB  . PHE A 1 157 ? -21.81222  -24.22935 -122.00537 1.000 23.40246 ? 157 PHE A CB  1 
ATOM   1279 C CG  . PHE A 1 157 ? -22.76499  -23.06382 -121.78400 1.000 30.54747 ? 157 PHE A CG  1 
ATOM   1280 C CD1 . PHE A 1 157 ? -23.04433  -22.16587 -122.80830 1.000 26.41314 ? 157 PHE A CD1 1 
ATOM   1281 C CD2 . PHE A 1 157 ? -23.33220  -22.83343 -120.52947 1.000 35.31438 ? 157 PHE A CD2 1 
ATOM   1282 C CE1 . PHE A 1 157 ? -23.90910  -21.08407 -122.61050 1.000 29.35124 ? 157 PHE A CE1 1 
ATOM   1283 C CE2 . PHE A 1 157 ? -24.20247  -21.74422 -120.31080 1.000 30.00702 ? 157 PHE A CE2 1 
ATOM   1284 C CZ  . PHE A 1 157 ? -24.49212  -20.86852 -121.35476 1.000 31.15720 ? 157 PHE A CZ  1 
ATOM   1285 N N   . MET A 1 158 ? -24.83358  -25.19011 -122.76779 1.000 27.32696 ? 158 MET A N   1 
ATOM   1286 C CA  . MET A 1 158 ? -26.16331  -25.55492 -122.27873 1.000 30.37056 ? 158 MET A CA  1 
ATOM   1287 C C   . MET A 1 158 ? -26.56974  -26.95527 -122.73140 1.000 31.00803 ? 158 MET A C   1 
ATOM   1288 O O   . MET A 1 158 ? -27.14805  -27.71427 -121.94805 1.000 30.77580 ? 158 MET A O   1 
ATOM   1289 C CB  . MET A 1 158 ? -27.18796  -24.53033 -122.74413 1.000 28.19975 ? 158 MET A CB  1 
ATOM   1290 C CG  . MET A 1 158 ? -26.95600  -23.13613 -122.18729 1.000 29.19326 ? 158 MET A CG  1 
ATOM   1291 S SD  . MET A 1 158 ? -28.11839  -21.97166 -122.92562 1.000 34.03129 ? 158 MET A SD  1 
ATOM   1292 C CE  . MET A 1 158 ? -27.40150  -21.69406 -124.55699 1.000 27.16499 ? 158 MET A CE  1 
ATOM   1293 N N   . GLU A 1 159 ? -26.29580  -27.30191 -123.99526 1.000 29.19669 ? 159 GLU A N   1 
ATOM   1294 C CA  . GLU A 1 159 ? -26.48325  -28.66757 -124.48292 1.000 34.30416 ? 159 GLU A CA  1 
ATOM   1295 C C   . GLU A 1 159 ? -25.79805  -29.68180 -123.57630 1.000 32.81252 ? 159 GLU A C   1 
ATOM   1296 O O   . GLU A 1 159 ? -26.37099  -30.72337 -123.22254 1.000 29.29024 ? 159 GLU A O   1 
ATOM   1297 C CB  . GLU A 1 159 ? -25.89742  -28.79777 -125.88610 1.000 33.24736 ? 159 GLU A CB  1 
ATOM   1298 C CG  . GLU A 1 159 ? -26.84001  -28.63733 -127.02106 1.000 52.35652 ? 159 GLU A CG  1 
ATOM   1299 C CD  . GLU A 1 159 ? -26.09135  -28.45470 -128.31776 1.000 50.27652 ? 159 GLU A CD  1 
ATOM   1300 O OE1 . GLU A 1 159 ? -25.41098  -29.42499 -128.73547 1.000 37.82830 ? 159 GLU A OE1 1 
ATOM   1301 O OE2 . GLU A 1 159 ? -26.18667  -27.34700 -128.90357 1.000 50.64764 ? 159 GLU A OE2 1 
ATOM   1302 N N   . GLN A 1 160 ? -24.54093  -29.41033 -123.23981 1.000 24.92966 ? 160 GLN A N   1 
ATOM   1303 C CA  . GLN A 1 160 ? -23.77443  -30.33333 -122.41821 1.000 27.70389 ? 160 GLN A CA  1 
ATOM   1304 C C   . GLN A 1 160 ? -24.37957  -30.44824 -121.02730 1.000 31.21700 ? 160 GLN A C   1 
ATOM   1305 O O   . GLN A 1 160 ? -24.55214  -31.55506 -120.50009 1.000 33.00215 ? 160 GLN A O   1 
ATOM   1306 C CB  . GLN A 1 160 ? -22.31288  -29.87365 -122.34715 1.000 28.34793 ? 160 GLN A CB  1 
ATOM   1307 C CG  . GLN A 1 160 ? -21.58089  -29.93155 -123.68733 1.000 31.18948 ? 160 GLN A CG  1 
ATOM   1308 C CD  . GLN A 1 160 ? -21.59170  -31.33164 -124.28154 1.000 41.43991 ? 160 GLN A CD  1 
ATOM   1309 O OE1 . GLN A 1 160 ? -21.08369  -32.27995 -123.67574 1.000 42.57808 ? 160 GLN A OE1 1 
ATOM   1310 N NE2 . GLN A 1 160 ? -22.19185  -31.47308 -125.46471 1.000 43.65129 ? 160 GLN A NE2 1 
ATOM   1311 N N   . ALA A 1 161 ? -24.72930  -29.30874 -120.42428 1.000 29.56001 ? 161 ALA A N   1 
ATOM   1312 C CA  . ALA A 1 161 ? -25.28096  -29.32855 -119.07448 1.000 29.02713 ? 161 ALA A CA  1 
ATOM   1313 C C   . ALA A 1 161 ? -26.56294  -30.15408 -119.00589 1.000 22.81492 ? 161 ALA A C   1 
ATOM   1314 O O   . ALA A 1 161 ? -26.77347  -30.89572 -118.04315 1.000 27.06490 ? 161 ALA A O   1 
ATOM   1315 C CB  . ALA A 1 161 ? -25.52275  -27.89981 -118.58427 1.000 29.39777 ? 161 ALA A CB  1 
ATOM   1316 N N   . PHE A 1 162 ? -27.42949  -30.05236 -120.01838 1.000 27.45027 ? 162 PHE A N   1 
ATOM   1317 C CA  . PHE A 1 162 ? -28.65771  -30.84339 -119.99592 1.000 26.33000 ? 162 PHE A CA  1 
ATOM   1318 C C   . PHE A 1 162 ? -28.35878  -32.33226 -120.13686 1.000 28.73693 ? 162 PHE A C   1 
ATOM   1319 O O   . PHE A 1 162 ? -28.99537  -33.16715 -119.47910 1.000 27.69529 ? 162 PHE A O   1 
ATOM   1320 C CB  . PHE A 1 162 ? -29.61576  -30.38275 -121.09966 1.000 20.73098 ? 162 PHE A CB  1 
ATOM   1321 C CG  . PHE A 1 162 ? -30.46812  -29.21981 -120.69822 1.000 25.48124 ? 162 PHE A CG  1 
ATOM   1322 C CD1 . PHE A 1 162 ? -31.57688  -29.40274 -119.88334 1.000 28.07218 ? 162 PHE A CD1 1 
ATOM   1323 C CD2 . PHE A 1 162 ? -30.14472  -27.93627 -121.10771 1.000 25.28856 ? 162 PHE A CD2 1 
ATOM   1324 C CE1 . PHE A 1 162 ? -32.35057  -28.32833 -119.49197 1.000 26.56809 ? 162 PHE A CE1 1 
ATOM   1325 C CE2 . PHE A 1 162 ? -30.91738  -26.85516 -120.73145 1.000 22.44667 ? 162 PHE A CE2 1 
ATOM   1326 C CZ  . PHE A 1 162 ? -32.02265  -27.04709 -119.92055 1.000 24.05825 ? 162 PHE A CZ  1 
ATOM   1327 N N   . LEU A 1 163 ? -27.40101  -32.68257 -120.99679 1.000 24.51796 ? 163 LEU A N   1 
ATOM   1328 C CA  . LEU A 1 163 ? -27.06204  -34.08699 -121.19294 1.000 25.57472 ? 163 LEU A CA  1 
ATOM   1329 C C   . LEU A 1 163 ? -26.42015  -34.66626 -119.93877 1.000 26.59740 ? 163 LEU A C   1 
ATOM   1330 O O   . LEU A 1 163 ? -26.67987  -35.81610 -119.57384 1.000 28.82300 ? 163 LEU A O   1 
ATOM   1331 C CB  . LEU A 1 163 ? -26.13407  -34.23466 -122.40784 1.000 29.53190 ? 163 LEU A CB  1 
ATOM   1332 C CG  . LEU A 1 163 ? -26.76564  -33.95961 -123.78453 1.000 33.81335 ? 163 LEU A CG  1 
ATOM   1333 C CD1 . LEU A 1 163 ? -25.69525  -33.72753 -124.83143 1.000 24.63094 ? 163 LEU A CD1 1 
ATOM   1334 C CD2 . LEU A 1 163 ? -27.69672  -35.08993 -124.23404 1.000 23.87870 ? 163 LEU A CD2 1 
ATOM   1335 N N   . TYR A 1 164 ? -25.60439  -33.86801 -119.25187 1.000 29.93545 ? 164 TYR A N   1 
ATOM   1336 C CA  . TYR A 1 164 ? -24.99296  -34.31000 -118.00359 1.000 27.68495 ? 164 TYR A CA  1 
ATOM   1337 C C   . TYR A 1 164 ? -26.04028  -34.56806 -116.92428 1.000 27.09074 ? 164 TYR A C   1 
ATOM   1338 O O   . TYR A 1 164 ? -25.94958  -35.55548 -116.18473 1.000 25.09314 ? 164 TYR A O   1 
ATOM   1339 C CB  . TYR A 1 164 ? -23.98834  -33.26238 -117.53214 1.000 27.15875 ? 164 TYR A CB  1 
ATOM   1340 C CG  . TYR A 1 164 ? -22.76419  -33.13606 -118.40106 1.000 32.69339 ? 164 TYR A CG  1 
ATOM   1341 C CD1 . TYR A 1 164 ? -22.36380  -34.17577 -119.22679 1.000 36.77395 ? 164 TYR A CD1 1 
ATOM   1342 C CD2 . TYR A 1 164 ? -21.98293  -31.98503 -118.37257 1.000 29.87404 ? 164 TYR A CD2 1 
ATOM   1343 C CE1 . TYR A 1 164 ? -21.21725  -34.06488 -120.01941 1.000 32.13639 ? 164 TYR A CE1 1 
ATOM   1344 C CE2 . TYR A 1 164 ? -20.84329  -31.86523 -119.16301 1.000 32.22920 ? 164 TYR A CE2 1 
ATOM   1345 C CZ  . TYR A 1 164 ? -20.46370  -32.91130 -119.98186 1.000 33.64497 ? 164 TYR A CZ  1 
ATOM   1346 O OH  . TYR A 1 164 ? -19.33021  -32.79985 -120.76264 1.000 41.87211 ? 164 TYR A OH  1 
ATOM   1347 N N   . ALA A 1 165 ? -27.04339  -33.68878 -116.81381 1.000 29.62589 ? 165 ALA A N   1 
ATOM   1348 C CA  . ALA A 1 165 ? -28.06198  -33.86799 -115.78278 1.000 23.82659 ? 165 ALA A CA  1 
ATOM   1349 C C   . ALA A 1 165 ? -28.96067  -35.05030 -116.10945 1.000 22.72601 ? 165 ALA A C   1 
ATOM   1350 O O   . ALA A 1 165 ? -29.38490  -35.78611 -115.20868 1.000 23.33839 ? 165 ALA A O   1 
ATOM   1351 C CB  . ALA A 1 165 ? -28.87101  -32.57913 -115.61644 1.000 23.89769 ? 165 ALA A CB  1 
ATOM   1352 N N   . TYR A 1 166 ? -29.24323  -35.25044 -117.40102 1.000 28.74129 ? 166 TYR A N   1 
ATOM   1353 C CA  . TYR A 1 166 ? -30.03485  -36.39335 -117.84857 1.000 24.78652 ? 166 TYR A CA  1 
ATOM   1354 C C   . TYR A 1 166 ? -29.33912  -37.70532 -117.51444 1.000 25.85768 ? 166 TYR A C   1 
ATOM   1355 O O   . TYR A 1 166 ? -29.96130  -38.64327 -117.00458 1.000 25.93382 ? 166 TYR A O   1 
ATOM   1356 C CB  . TYR A 1 166 ? -30.27644  -36.28844 -119.35514 1.000 24.05753 ? 166 TYR A CB  1 
ATOM   1357 C CG  . TYR A 1 166 ? -31.12036  -37.39982 -119.91854 1.000 23.27797 ? 166 TYR A CG  1 
ATOM   1358 C CD1 . TYR A 1 166 ? -32.46609  -37.52583 -119.56954 1.000 24.53750 ? 166 TYR A CD1 1 
ATOM   1359 C CD2 . TYR A 1 166 ? -30.58118  -38.32551 -120.79293 1.000 21.83690 ? 166 TYR A CD2 1 
ATOM   1360 C CE1 . TYR A 1 166 ? -33.24449  -38.52956 -120.08586 1.000 21.74003 ? 166 TYR A CE1 1 
ATOM   1361 C CE2 . TYR A 1 166 ? -31.36390  -39.34403 -121.32251 1.000 27.01298 ? 166 TYR A CE2 1 
ATOM   1362 C CZ  . TYR A 1 166 ? -32.69134  -39.43513 -120.96392 1.000 27.08070 ? 166 TYR A CZ  1 
ATOM   1363 O OH  . TYR A 1 166 ? -33.46947  -40.44904 -121.47713 1.000 28.93168 ? 166 TYR A OH  1 
ATOM   1364 N N   . GLU A 1 167 ? -28.03903  -37.78792 -117.80122 1.000 25.49058 ? 167 GLU A N   1 
ATOM   1365 C CA  . GLU A 1 167 ? -27.28994  -38.98895 -117.46488 1.000 27.98073 ? 167 GLU A CA  1 
ATOM   1366 C C   . GLU A 1 167 ? -27.34027  -39.27507 -115.96491 1.000 28.99904 ? 167 GLU A C   1 
ATOM   1367 O O   . GLU A 1 167 ? -27.47611  -40.43294 -115.55411 1.000 28.48892 ? 167 GLU A O   1 
ATOM   1368 C CB  . GLU A 1 167 ? -25.84347  -38.85531 -117.94219 1.000 26.14247 ? 167 GLU A CB  1 
ATOM   1369 C CG  . GLU A 1 167 ? -25.02148  -40.10267 -117.62506 1.000 35.93465 ? 167 GLU A CG  1 
ATOM   1370 C CD  . GLU A 1 167 ? -23.68320  -40.16019 -118.33730 1.000 49.58652 ? 167 GLU A CD  1 
ATOM   1371 O OE1 . GLU A 1 167 ? -22.87416  -39.20648 -118.20230 1.000 54.19108 ? 167 GLU A OE1 1 
ATOM   1372 O OE2 . GLU A 1 167 ? -23.45224  -41.17349 -119.03532 1.000 47.63472 ? 167 GLU A OE2 1 
ATOM   1373 N N   . ALA A 1 168 ? -27.25286  -38.22798 -115.13325 1.000 24.37219 ? 168 ALA A N   1 
ATOM   1374 C CA  . ALA A 1 168 ? -27.21196  -38.41551 -113.68314 1.000 20.44358 ? 168 ALA A CA  1 
ATOM   1375 C C   . ALA A 1 168 ? -28.57039  -38.84727 -113.13672 1.000 29.37683 ? 168 ALA A C   1 
ATOM   1376 O O   . ALA A 1 168 ? -28.64098  -39.70365 -112.25068 1.000 29.98041 ? 168 ALA A O   1 
ATOM   1377 C CB  . ALA A 1 168 ? -26.73209  -37.13328 -113.00126 1.000 26.11942 ? 168 ALA A CB  1 
ATOM   1378 N N   . ASP A 1 169 ? -29.66119  -38.28946 -113.66044 1.000 28.21625 ? 169 ASP A N   1 
ATOM   1379 C CA  . ASP A 1 169 ? -31.00302  -38.73433 -113.28028 1.000 27.00226 ? 169 ASP A CA  1 
ATOM   1380 C C   . ASP A 1 169 ? -31.92249  -38.62639 -114.48855 1.000 27.37692 ? 169 ASP A C   1 
ATOM   1381 O O   . ASP A 1 169 ? -32.58670  -37.60195 -114.69950 1.000 25.38439 ? 169 ASP A O   1 
ATOM   1382 C CB  . ASP A 1 169 ? -31.54755  -37.92933 -112.10129 1.000 24.89712 ? 169 ASP A CB  1 
ATOM   1383 C CG  . ASP A 1 169 ? -32.89267  -38.43389 -111.60661 1.000 27.24073 ? 169 ASP A CG  1 
ATOM   1384 O OD1 . ASP A 1 169 ? -33.36775  -39.47424 -112.10390 1.000 24.60100 ? 169 ASP A OD1 1 
ATOM   1385 O OD2 . ASP A 1 169 ? -33.46171  -37.80207 -110.68729 1.000 25.80214 ? 169 ASP A OD2 1 
ATOM   1386 N N   . PRO A 1 170 ? -32.00476  -39.68291 -115.30054 1.000 27.30495 ? 170 PRO A N   1 
ATOM   1387 C CA  . PRO A 1 170 ? -32.88768  -39.63648 -116.47630 1.000 28.96225 ? 170 PRO A CA  1 
ATOM   1388 C C   . PRO A 1 170 ? -34.37201  -39.58149 -116.13763 1.000 31.29766 ? 170 PRO A C   1 
ATOM   1389 O O   . PRO A 1 170 ? -35.17924  -39.37552 -117.05296 1.000 32.73462 ? 170 PRO A O   1 
ATOM   1390 C CB  . PRO A 1 170 ? -32.53155  -40.91770 -117.23900 1.000 29.25472 ? 170 PRO A CB  1 
ATOM   1391 C CG  . PRO A 1 170 ? -31.93075  -41.82809 -116.21570 1.000 32.70370 ? 170 PRO A CG  1 
ATOM   1392 C CD  . PRO A 1 170 ? -31.28182  -40.96264 -115.17963 1.000 28.23060 ? 170 PRO A CD  1 
ATOM   1393 N N   . ASP A 1 171 ? -34.76447  -39.73535 -114.86997 1.000 26.14176 ? 171 ASP A N   1 
ATOM   1394 C CA  . ASP A 1 171 ? -36.17359  -39.59481 -114.52119 1.000 31.03694 ? 171 ASP A CA  1 
ATOM   1395 C C   . ASP A 1 171 ? -36.54514  -38.16980 -114.15579 1.000 27.92140 ? 171 ASP A C   1 
ATOM   1396 O O   . ASP A 1 171 ? -37.72885  -37.89892 -113.95528 1.000 26.33684 ? 171 ASP A O   1 
ATOM   1397 C CB  . ASP A 1 171 ? -36.56021  -40.51151 -113.34525 1.000 27.22072 ? 171 ASP A CB  1 
ATOM   1398 C CG  . ASP A 1 171 ? -36.61159  -41.97596 -113.73458 1.000 33.10510 ? 171 ASP A CG  1 
ATOM   1399 O OD1 . ASP A 1 171 ? -37.32829  -42.30015 -114.70516 1.000 38.07462 ? 171 ASP A OD1 1 
ATOM   1400 O OD2 . ASP A 1 171 ? -35.94889  -42.80007 -113.05650 1.000 44.21580 ? 171 ASP A OD2 1 
ATOM   1401 N N   . ALA A 1 172 ? -35.56902  -37.27145 -114.02143 1.000 27.42180 ? 172 ALA A N   1 
ATOM   1402 C CA  . ALA A 1 172 ? -35.86911  -35.89754 -113.65317 1.000 25.56843 ? 172 ALA A CA  1 
ATOM   1403 C C   . ALA A 1 172 ? -36.39275  -35.11226 -114.84989 1.000 23.44784 ? 172 ALA A C   1 
ATOM   1404 O O   . ALA A 1 172 ? -36.01754  -35.36267 -115.99720 1.000 27.42527 ? 172 ALA A O   1 
ATOM   1405 C CB  . ALA A 1 172 ? -34.62806  -35.20593 -113.09009 1.000 20.36293 ? 172 ALA A CB  1 
ATOM   1406 N N   . LEU A 1 173 ? -37.26879  -34.14717 -114.56994 1.000 28.84335 ? 173 LEU A N   1 
ATOM   1407 C CA  . LEU A 1 173 ? -37.64305  -33.14436 -115.55745 1.000 23.39928 ? 173 LEU A CA  1 
ATOM   1408 C C   . LEU A 1 173 ? -36.61398  -32.02145 -115.50713 1.000 25.72805 ? 173 LEU A C   1 
ATOM   1409 O O   . LEU A 1 173 ? -36.31987  -31.48539 -114.43353 1.000 27.39591 ? 173 LEU A O   1 
ATOM   1410 C CB  . LEU A 1 173 ? -39.05248  -32.60895 -115.29793 1.000 23.51949 ? 173 LEU A CB  1 
ATOM   1411 C CG  . LEU A 1 173 ? -40.20741  -33.62397 -115.26681 1.000 29.42716 ? 173 LEU A CG  1 
ATOM   1412 C CD1 . LEU A 1 173 ? -41.50678  -32.94231 -114.85991 1.000 26.65369 ? 173 LEU A CD1 1 
ATOM   1413 C CD2 . LEU A 1 173 ? -40.38787  -34.31968 -116.60828 1.000 28.51798 ? 173 LEU A CD2 1 
ATOM   1414 N N   . LEU A 1 174 ? -36.04397  -31.68910 -116.66061 1.000 24.27495 ? 174 LEU A N   1 
ATOM   1415 C CA  . LEU A 1 174 ? -34.95414  -30.72695 -116.75680 1.000 25.50209 ? 174 LEU A CA  1 
ATOM   1416 C C   . LEU A 1 174 ? -35.47803  -29.43637 -117.37613 1.000 27.96434 ? 174 LEU A C   1 
ATOM   1417 O O   . LEU A 1 174 ? -36.14702  -29.46662 -118.41725 1.000 22.21576 ? 174 LEU A O   1 
ATOM   1418 C CB  . LEU A 1 174 ? -33.79248  -31.30432 -117.57546 1.000 25.28413 ? 174 LEU A CB  1 
ATOM   1419 C CG  . LEU A 1 174 ? -33.26749  -32.66945 -117.10057 1.000 27.56007 ? 174 LEU A CG  1 
ATOM   1420 C CD1 . LEU A 1 174 ? -32.04057  -33.11338 -117.89172 1.000 23.48461 ? 174 LEU A CD1 1 
ATOM   1421 C CD2 . LEU A 1 174 ? -32.96349  -32.67016 -115.58735 1.000 23.12172 ? 174 LEU A CD2 1 
ATOM   1422 N N   . PHE A 1 175 ? -35.16066  -28.30670 -116.74107 1.000 26.64081 ? 175 PHE A N   1 
ATOM   1423 C CA  . PHE A 1 175 ? -35.79643  -27.03167 -117.03507 1.000 23.62943 ? 175 PHE A CA  1 
ATOM   1424 C C   . PHE A 1 175 ? -34.79034  -25.98724 -117.48998 1.000 23.95683 ? 175 PHE A C   1 
ATOM   1425 O O   . PHE A 1 175 ? -33.67073  -25.91417 -116.97273 1.000 22.81086 ? 175 PHE A O   1 
ATOM   1426 C CB  . PHE A 1 175 ? -36.54094  -26.49021 -115.80739 1.000 21.92714 ? 175 PHE A CB  1 
ATOM   1427 C CG  . PHE A 1 175 ? -37.89045  -27.11336 -115.59889 1.000 22.71480 ? 175 PHE A CG  1 
ATOM   1428 C CD1 . PHE A 1 175 ? -38.01052  -28.36941 -115.03836 1.000 19.91665 ? 175 PHE A CD1 1 
ATOM   1429 C CD2 . PHE A 1 175 ? -39.03435  -26.44587 -115.97947 1.000 19.17400 ? 175 PHE A CD2 1 
ATOM   1430 C CE1 . PHE A 1 175 ? -39.23712  -28.94546 -114.86391 1.000 25.95204 ? 175 PHE A CE1 1 
ATOM   1431 C CE2 . PHE A 1 175 ? -40.26300  -27.01845 -115.79960 1.000 22.93072 ? 175 PHE A CE2 1 
ATOM   1432 C CZ  . PHE A 1 175 ? -40.36413  -28.27439 -115.25010 1.000 19.45213 ? 175 PHE A CZ  1 
ATOM   1433 N N   . TYR A 1 176 ? -35.20521  -25.16285 -118.44606 1.000 22.20803 ? 176 TYR A N   1 
ATOM   1434 C CA  . TYR A 1 176 ? -34.59356  -23.85647 -118.63488 1.000 21.86885 ? 176 TYR A CA  1 
ATOM   1435 C C   . TYR A 1 176 ? -35.41090  -22.85615 -117.81917 1.000 19.74407 ? 176 TYR A C   1 
ATOM   1436 O O   . TYR A 1 176 ? -36.63979  -22.81369 -117.94809 1.000 21.46348 ? 176 TYR A O   1 
ATOM   1437 C CB  . TYR A 1 176 ? -34.54483  -23.45397 -120.12214 1.000 25.96514 ? 176 TYR A CB  1 
ATOM   1438 C CG  . TYR A 1 176 ? -33.95809  -22.06918 -120.28026 1.000 24.38781 ? 176 TYR A CG  1 
ATOM   1439 C CD1 . TYR A 1 176 ? -32.57801  -21.88370 -120.32566 1.000 19.60107 ? 176 TYR A CD1 1 
ATOM   1440 C CD2 . TYR A 1 176 ? -34.77581  -20.94259 -120.28928 1.000 17.65359 ? 176 TYR A CD2 1 
ATOM   1441 C CE1 . TYR A 1 176 ? -32.02769  -20.61755 -120.40865 1.000 22.11568 ? 176 TYR A CE1 1 
ATOM   1442 C CE2 . TYR A 1 176 ? -34.23723  -19.66492 -120.36268 1.000 21.25430 ? 176 TYR A CE2 1 
ATOM   1443 C CZ  . TYR A 1 176 ? -32.86445  -19.50385 -120.42623 1.000 22.47550 ? 176 TYR A CZ  1 
ATOM   1444 O OH  . TYR A 1 176 ? -32.32732  -18.23178 -120.50806 1.000 28.96380 ? 176 TYR A OH  1 
ATOM   1445 N N   . ASN A 1 177 ? -34.73202  -22.04705 -116.99313 1.000 23.63013 ? 177 ASN A N   1 
ATOM   1446 C CA  . ASN A 1 177 ? -35.37091  -21.15409 -116.02043 1.000 22.85757 ? 177 ASN A CA  1 
ATOM   1447 C C   . ASN A 1 177 ? -34.90401  -19.71892 -116.23265 1.000 21.58615 ? 177 ASN A C   1 
ATOM   1448 O O   . ASN A 1 177 ? -33.70674  -19.46272 -116.40349 1.000 25.33310 ? 177 ASN A O   1 
ATOM   1449 C CB  . ASN A 1 177 ? -35.04658  -21.59848 -114.57321 1.000 22.33719 ? 177 ASN A CB  1 
ATOM   1450 C CG  . ASN A 1 177 ? -35.92681  -20.93679 -113.53214 1.000 22.92089 ? 177 ASN A CG  1 
ATOM   1451 O OD1 . ASN A 1 177 ? -37.15505  -21.06978 -113.55261 1.000 24.09855 ? 177 ASN A OD1 1 
ATOM   1452 N ND2 . ASN A 1 177 ? -35.29444  -20.23381 -112.58928 1.000 22.65235 ? 177 ASN A ND2 1 
ATOM   1453 N N   . ASP A 1 178 ? -35.83962  -18.77443 -116.20028 1.000 22.51361 ? 178 ASP A N   1 
ATOM   1454 C CA  . ASP A 1 178 ? -35.48151  -17.40237 -116.54248 1.000 25.83704 ? 178 ASP A CA  1 
ATOM   1455 C C   . ASP A 1 178 ? -36.57183  -16.45587 -116.06537 1.000 26.44577 ? 178 ASP A C   1 
ATOM   1456 O O   . ASP A 1 178 ? -37.70805  -16.86393 -115.80495 1.000 22.70465 ? 178 ASP A O   1 
ATOM   1457 C CB  . ASP A 1 178 ? -35.26650  -17.24602 -118.05807 1.000 21.71417 ? 178 ASP A CB  1 
ATOM   1458 C CG  . ASP A 1 178 ? -34.16843  -16.25069 -118.40322 1.000 23.63427 ? 178 ASP A CG  1 
ATOM   1459 O OD1 . ASP A 1 178 ? -33.76561  -15.44927 -117.53508 1.000 23.09331 ? 178 ASP A OD1 1 
ATOM   1460 O OD2 . ASP A 1 178 ? -33.69896  -16.28493 -119.55772 1.000 30.76396 ? 178 ASP A OD2 1 
ATOM   1461 N N   . TYR A 1 179 ? -36.20986  -15.17970 -115.99402 1.000 19.04918 ? 179 TYR A N   1 
ATOM   1462 C CA  . TYR A 1 179 ? -37.08292  -14.09608 -115.56603 1.000 22.96146 ? 179 TYR A CA  1 
ATOM   1463 C C   . TYR A 1 179 ? -37.30592  -13.10574 -116.71066 1.000 24.83835 ? 179 TYR A C   1 
ATOM   1464 O O   . TYR A 1 179 ? -36.65670  -13.16609 -117.75928 1.000 21.06265 ? 179 TYR A O   1 
ATOM   1465 C CB  . TYR A 1 179 ? -36.48258  -13.38599 -114.35139 1.000 25.76932 ? 179 TYR A CB  1 
ATOM   1466 C CG  . TYR A 1 179 ? -35.22850  -12.58834 -114.67779 1.000 22.86653 ? 179 TYR A CG  1 
ATOM   1467 C CD1 . TYR A 1 179 ? -33.97261  -13.20177 -114.73213 1.000 28.03611 ? 179 TYR A CD1 1 
ATOM   1468 C CD2 . TYR A 1 179 ? -35.29911  -11.22158 -114.92991 1.000 20.22607 ? 179 TYR A CD2 1 
ATOM   1469 C CE1 . TYR A 1 179 ? -32.80778  -12.45745 -115.01934 1.000 27.88536 ? 179 TYR A CE1 1 
ATOM   1470 C CE2 . TYR A 1 179 ? -34.15820  -10.47936 -115.22703 1.000 23.32887 ? 179 TYR A CE2 1 
ATOM   1471 C CZ  . TYR A 1 179 ? -32.90974  -11.09676 -115.26667 1.000 30.79270 ? 179 TYR A CZ  1 
ATOM   1472 O OH  . TYR A 1 179 ? -31.77802  -10.34998 -115.56903 1.000 26.62041 ? 179 TYR A OH  1 
ATOM   1473 N N   . ASN A 1 180 ? -38.24508  -12.17829 -116.49697 1.000 28.41222 ? 180 ASN A N   1 
ATOM   1474 C CA  . ASN A 1 180 ? -38.73158  -11.30399 -117.57052 1.000 24.18771 ? 180 ASN A CA  1 
ATOM   1475 C C   . ASN A 1 180 ? -39.11726  -12.12892 -118.80105 1.000 27.40279 ? 180 ASN A C   1 
ATOM   1476 O O   . ASN A 1 180 ? -39.02730  -11.67969 -119.94605 1.000 30.06780 ? 180 ASN A O   1 
ATOM   1477 C CB  . ASN A 1 180 ? -37.70806  -10.21335 -117.90021 1.000 20.72852 ? 180 ASN A CB  1 
ATOM   1478 C CG  . ASN A 1 180 ? -37.62457  -9.16118  -116.80437 1.000 26.79859 ? 180 ASN A CG  1 
ATOM   1479 O OD1 . ASN A 1 180 ? -38.57319  -8.99039  -116.01442 1.000 23.77334 ? 180 ASN A OD1 1 
ATOM   1480 N ND2 . ASN A 1 180 ? -36.49715  -8.45520  -116.73878 1.000 21.74120 ? 180 ASN A ND2 1 
ATOM   1481 N N   . GLU A 1 181 ? -39.59109  -13.34626 -118.54103 1.000 25.05088 ? 181 GLU A N   1 
ATOM   1482 C CA  . GLU A 1 181 ? -39.92319  -14.34844 -119.54050 1.000 22.89646 ? 181 GLU A CA  1 
ATOM   1483 C C   . GLU A 1 181 ? -41.15410  -13.99316 -120.37971 1.000 24.20365 ? 181 GLU A C   1 
ATOM   1484 O O   . GLU A 1 181 ? -41.43221  -14.69642 -121.35837 1.000 24.98353 ? 181 GLU A O   1 
ATOM   1485 C CB  . GLU A 1 181 ? -40.12026  -15.68895 -118.81782 1.000 18.58932 ? 181 GLU A CB  1 
ATOM   1486 C CG  . GLU A 1 181 ? -41.36587  -15.77677 -117.88036 1.000 23.76269 ? 181 GLU A CG  1 
ATOM   1487 C CD  . GLU A 1 181 ? -41.40445  -14.73268 -116.73160 1.000 25.35423 ? 181 GLU A CD  1 
ATOM   1488 O OE1 . GLU A 1 181 ? -40.39952  -14.53892 -116.01268 1.000 22.38764 ? 181 GLU A OE1 1 
ATOM   1489 O OE2 . GLU A 1 181 ? -42.46449  -14.11801 -116.52705 1.000 28.36807 ? 181 GLU A OE2 1 
ATOM   1490 N N   . CYS A 1 182 ? -41.90323  -12.94822 -120.01060 1.000 28.66068 ? 182 CYS A N   1 
ATOM   1491 C CA  . CYS A 1 182 ? -43.10733  -12.51944 -120.72062 1.000 22.11016 ? 182 CYS A CA  1 
ATOM   1492 C C   . CYS A 1 182 ? -42.95622  -11.21734 -121.49203 1.000 26.62663 ? 182 CYS A C   1 
ATOM   1493 O O   . CYS A 1 182 ? -43.94047  -10.75468 -122.08154 1.000 24.90490 ? 182 CYS A O   1 
ATOM   1494 C CB  . CYS A 1 182 ? -44.29175  -12.35346 -119.76780 1.000 28.38307 ? 182 CYS A CB  1 
ATOM   1495 S SG  . CYS A 1 182 ? -44.74567  -13.83735 -118.88361 1.000 24.77466 ? 182 CYS A SG  1 
ATOM   1496 N N   . PHE A 1 183 ? -41.78834  -10.58637 -121.47007 1.000 27.43159 ? 183 PHE A N   1 
ATOM   1497 C CA  . PHE A 1 183 ? -41.60934  -9.43857  -122.34840 1.000 29.30163 ? 183 PHE A CA  1 
ATOM   1498 C C   . PHE A 1 183 ? -41.30888  -9.95613  -123.74791 1.000 32.28670 ? 183 PHE A C   1 
ATOM   1499 O O   . PHE A 1 183 ? -40.40077  -10.78186 -123.91140 1.000 30.22022 ? 183 PHE A O   1 
ATOM   1500 C CB  . PHE A 1 183 ? -40.49405  -8.51390  -121.86390 1.000 19.67225 ? 183 PHE A CB  1 
ATOM   1501 C CG  . PHE A 1 183 ? -40.71607  -7.96410  -120.46883 1.000 28.46418 ? 183 PHE A CG  1 
ATOM   1502 C CD1 . PHE A 1 183 ? -41.98239  -7.93942  -119.91217 1.000 33.05804 ? 183 PHE A CD1 1 
ATOM   1503 C CD2 . PHE A 1 183 ? -39.65246  -7.50127  -119.71353 1.000 24.68473 ? 183 PHE A CD2 1 
ATOM   1504 C CE1 . PHE A 1 183 ? -42.18671  -7.46163  -118.62950 1.000 28.23558 ? 183 PHE A CE1 1 
ATOM   1505 C CE2 . PHE A 1 183 ? -39.84757  -7.02013  -118.42312 1.000 29.15571 ? 183 PHE A CE2 1 
ATOM   1506 C CZ  . PHE A 1 183 ? -41.11845  -6.99885  -117.88104 1.000 28.39625 ? 183 PHE A CZ  1 
ATOM   1507 N N   . PRO A 1 184 ? -42.07406  -9.53405  -124.76190 1.000 29.65490 ? 184 PRO A N   1 
ATOM   1508 C CA  . PRO A 1 184 ? -42.02920  -10.23273 -126.05897 1.000 24.50954 ? 184 PRO A CA  1 
ATOM   1509 C C   . PRO A 1 184 ? -40.63870  -10.42418 -126.61014 1.000 25.41790 ? 184 PRO A C   1 
ATOM   1510 O O   . PRO A 1 184 ? -40.33336  -11.49458 -127.14223 1.000 30.13381 ? 184 PRO A O   1 
ATOM   1511 C CB  . PRO A 1 184 ? -42.87621  -9.33202  -126.96505 1.000 24.26859 ? 184 PRO A CB  1 
ATOM   1512 C CG  . PRO A 1 184 ? -43.88600  -8.70887  -126.01546 1.000 32.08477 ? 184 PRO A CG  1 
ATOM   1513 C CD  . PRO A 1 184 ? -43.18925  -8.56749  -124.68004 1.000 31.37240 ? 184 PRO A CD  1 
ATOM   1514 N N   . GLU A 1 185 ? -39.77648  -9.42231  -126.50337 1.000 28.41980 ? 185 GLU A N   1 
ATOM   1515 C CA  . GLU A 1 185 ? -38.47048  -9.56326  -127.12288 1.000 30.75787 ? 185 GLU A CA  1 
ATOM   1516 C C   . GLU A 1 185 ? -37.69629  -10.70325 -126.47152 1.000 38.38699 ? 185 GLU A C   1 
ATOM   1517 O O   . GLU A 1 185 ? -37.06896  -11.51529 -127.16211 1.000 32.50666 ? 185 GLU A O   1 
ATOM   1518 C CB  . GLU A 1 185 ? -37.70642  -8.24497  -127.03268 1.000 36.20067 ? 185 GLU A CB  1 
ATOM   1519 C CG  . GLU A 1 185 ? -36.27194  -8.33115  -127.52729 1.000 56.92940 ? 185 GLU A CG  1 
ATOM   1520 C CD  . GLU A 1 185 ? -35.50635  -7.02477  -127.34710 1.000 69.75652 ? 185 GLU A CD  1 
ATOM   1521 O OE1 . GLU A 1 185 ? -35.97172  -5.99049  -127.88616 1.000 69.64357 ? 185 GLU A OE1 1 
ATOM   1522 O OE2 . GLU A 1 185 ? -34.44038  -7.03644  -126.68349 1.000 60.78156 ? 185 GLU A OE2 1 
ATOM   1523 N N   . LYS A 1 186 ? -37.77270  -10.80189 -125.13731 1.000 33.50709 ? 186 LYS A N   1 
ATOM   1524 C CA  . LYS A 1 186 ? -37.07847  -11.86285 -124.41788 1.000 33.11621 ? 186 LYS A CA  1 
ATOM   1525 C C   . LYS A 1 186 ? -37.79201  -13.19028 -124.59035 1.000 28.92667 ? 186 LYS A C   1 
ATOM   1526 O O   . LYS A 1 186 ? -37.13095  -14.21164 -124.79048 1.000 27.81456 ? 186 LYS A O   1 
ATOM   1527 C CB  . LYS A 1 186 ? -36.93349  -11.50419 -122.92061 1.000 28.39257 ? 186 LYS A CB  1 
ATOM   1528 C CG  . LYS A 1 186 ? -35.91114  -12.39753 -122.18407 1.000 27.14144 ? 186 LYS A CG  1 
ATOM   1529 C CD  . LYS A 1 186 ? -35.52077  -11.89446 -120.79364 1.000 25.18775 ? 186 LYS A CD  1 
ATOM   1530 C CE  . LYS A 1 186 ? -34.37762  -12.74432 -120.20167 1.000 29.16831 ? 186 LYS A CE  1 
ATOM   1531 N NZ  . LYS A 1 186 ? -34.03970  -12.37905 -118.78729 1.000 22.73475 ? 186 LYS A NZ  1 
ATOM   1532 N N   . ARG A 1 187 ? -39.13512  -13.18777 -124.54455 1.000 27.42144 ? 187 ARG A N   1 
ATOM   1533 C CA  . ARG A 1 187 ? -39.89259  -14.40238 -124.81768 1.000 29.56398 ? 187 ARG A CA  1 
ATOM   1534 C C   . ARG A 1 187 ? -39.39209  -15.08359 -126.08050 1.000 29.70224 ? 187 ARG A C   1 
ATOM   1535 O O   . ARG A 1 187 ? -39.15077  -16.29195 -126.08310 1.000 30.37350 ? 187 ARG A O   1 
ATOM   1536 C CB  . ARG A 1 187 ? -41.38647  -14.09672 -124.92747 1.000 23.87428 ? 187 ARG A CB  1 
ATOM   1537 C CG  . ARG A 1 187 ? -42.24039  -15.27579 -125.41088 1.000 32.39026 ? 187 ARG A CG  1 
ATOM   1538 C CD  . ARG A 1 187 ? -43.61047  -14.79008 -125.91655 1.000 26.91744 ? 187 ARG A CD  1 
ATOM   1539 N NE  . ARG A 1 187 ? -43.48373  -14.12436 -127.20783 1.000 35.98731 ? 187 ARG A NE  1 
ATOM   1540 C CZ  . ARG A 1 187 ? -44.16717  -13.05011 -127.59322 1.000 33.41018 ? 187 ARG A CZ  1 
ATOM   1541 N NH1 . ARG A 1 187 ? -45.01735  -12.44693 -126.77457 1.000 27.92338 ? 187 ARG A NH1 1 
ATOM   1542 N NH2 . ARG A 1 187 ? -43.95146  -12.54564 -128.79815 1.000 36.81219 ? 187 ARG A NH2 1 
ATOM   1543 N N   . GLU A 1 188 ? -39.16105  -14.31214 -127.15333 1.000 33.36361 ? 188 GLU A N   1 
ATOM   1544 C CA  . GLU A 1 188 ? -38.80568  -14.91307 -128.43369 1.000 29.30927 ? 188 GLU A CA  1 
ATOM   1545 C C   . GLU A 1 188 ? -37.38533  -15.44399 -128.40893 1.000 34.96393 ? 188 GLU A C   1 
ATOM   1546 O O   . GLU A 1 188 ? -37.08012  -16.43750 -129.08014 1.000 31.75170 ? 188 GLU A O   1 
ATOM   1547 C CB  . GLU A 1 188 ? -38.98586  -13.90028 -129.56483 1.000 23.25183 ? 188 GLU A CB  1 
ATOM   1548 C CG  . GLU A 1 188 ? -40.43607  -13.58575 -129.85965 1.000 24.09356 ? 188 GLU A CG  1 
ATOM   1549 C CD  . GLU A 1 188 ? -41.25972  -14.80628 -130.24160 1.000 33.03375 ? 188 GLU A CD  1 
ATOM   1550 O OE1 . GLU A 1 188 ? -40.77523  -15.60238 -131.07253 1.000 35.47360 ? 188 GLU A OE1 1 
ATOM   1551 O OE2 . GLU A 1 188 ? -42.39853  -14.95260 -129.74404 1.000 26.65187 ? 188 GLU A OE2 1 
ATOM   1552 N N   . LYS A 1 189 ? -36.49949  -14.79795 -127.64019 1.000 28.36402 ? 189 LYS A N   1 
ATOM   1553 C CA  . LYS A 1 189 ? -35.17652  -15.36529 -127.43690 1.000 29.02651 ? 189 LYS A CA  1 
ATOM   1554 C C   . LYS A 1 189 ? -35.26525  -16.68533 -126.69133 1.000 31.45126 ? 189 LYS A C   1 
ATOM   1555 O O   . LYS A 1 189 ? -34.59773  -17.65403 -127.06439 1.000 37.55891 ? 189 LYS A O   1 
ATOM   1556 C CB  . LYS A 1 189 ? -34.27821  -14.38146 -126.69231 1.000 31.09954 ? 189 LYS A CB  1 
ATOM   1557 C CG  . LYS A 1 189 ? -33.88061  -13.17571 -127.49873 1.000 33.88255 ? 189 LYS A CG  1 
ATOM   1558 C CD  . LYS A 1 189 ? -33.01584  -12.26445 -126.69110 1.000 37.05174 ? 189 LYS A CD  1 
ATOM   1559 C CE  . LYS A 1 189 ? -32.83045  -10.94084 -127.37489 1.000 38.34849 ? 189 LYS A CE  1 
ATOM   1560 N NZ  . LYS A 1 189 ? -31.91596  -10.13472 -126.53299 1.000 39.22074 ? 189 LYS A NZ  1 
ATOM   1561 N N   . ILE A 1 190 ? -36.10472  -16.75570 -125.65542 1.000 30.07801 ? 190 ILE A N   1 
ATOM   1562 C CA  . ILE A 1 190 ? -36.18653  -17.97404 -124.85572 1.000 28.65049 ? 190 ILE A CA  1 
ATOM   1563 C C   . ILE A 1 190 ? -36.81349  -19.09038 -125.67292 1.000 28.71821 ? 190 ILE A C   1 
ATOM   1564 O O   . ILE A 1 190 ? -36.28784  -20.20833 -125.72968 1.000 31.00716 ? 190 ILE A O   1 
ATOM   1565 C CB  . ILE A 1 190 ? -36.96107  -17.71777 -123.55053 1.000 26.40747 ? 190 ILE A CB  1 
ATOM   1566 C CG1 . ILE A 1 190 ? -36.10791  -16.89222 -122.58878 1.000 27.07877 ? 190 ILE A CG1 1 
ATOM   1567 C CG2 . ILE A 1 190 ? -37.41872  -19.05828 -122.89880 1.000 17.75000 ? 190 ILE A CG2 1 
ATOM   1568 C CD1 . ILE A 1 190 ? -36.91109  -16.28187 -121.43456 1.000 27.09888 ? 190 ILE A CD1 1 
ATOM   1569 N N   . PHE A 1 191 ? -37.94075  -18.79397 -126.32739 1.000 31.29249 ? 191 PHE A N   1 
ATOM   1570 C CA  . PHE A 1 191 ? -38.55068  -19.72583 -127.27378 1.000 29.28814 ? 191 PHE A CA  1 
ATOM   1571 C C   . PHE A 1 191 ? -37.53922  -20.20993 -128.31728 1.000 30.43134 ? 191 PHE A C   1 
ATOM   1572 O O   . PHE A 1 191 ? -37.40904  -21.41604 -128.55920 1.000 34.40382 ? 191 PHE A O   1 
ATOM   1573 C CB  . PHE A 1 191 ? -39.75414  -19.05287 -127.94093 1.000 27.90724 ? 191 PHE A CB  1 
ATOM   1574 C CG  . PHE A 1 191 ? -40.42652  -19.89599 -128.99748 1.000 25.81478 ? 191 PHE A CG  1 
ATOM   1575 C CD1 . PHE A 1 191 ? -41.44794  -20.77209 -128.65870 1.000 26.39784 ? 191 PHE A CD1 1 
ATOM   1576 C CD2 . PHE A 1 191 ? -40.03944  -19.80646 -130.33647 1.000 33.02359 ? 191 PHE A CD2 1 
ATOM   1577 C CE1 . PHE A 1 191 ? -42.08034  -21.53862 -129.63057 1.000 33.57491 ? 191 PHE A CE1 1 
ATOM   1578 C CE2 . PHE A 1 191 ? -40.66268  -20.58304 -131.32263 1.000 31.49124 ? 191 PHE A CE2 1 
ATOM   1579 C CZ  . PHE A 1 191 ? -41.68473  -21.45017 -130.96524 1.000 29.86752 ? 191 PHE A CZ  1 
ATOM   1580 N N   . ALA A 1 192 ? -36.80559  -19.28305 -128.94271 1.000 32.96215 ? 192 ALA A N   1 
ATOM   1581 C CA  . ALA A 1 192 ? -35.81824  -19.67915 -129.95019 1.000 34.18804 ? 192 ALA A CA  1 
ATOM   1582 C C   . ALA A 1 192 ? -34.75434  -20.59349 -129.36250 1.000 31.42788 ? 192 ALA A C   1 
ATOM   1583 O O   . ALA A 1 192 ? -34.37428  -21.59635 -129.97662 1.000 32.51207 ? 192 ALA A O   1 
ATOM   1584 C CB  . ALA A 1 192 ? -35.15126  -18.44838 -130.56911 1.000 27.20174 ? 192 ALA A CB  1 
ATOM   1585 N N   . LEU A 1 193 ? -34.24219  -20.25063 -128.18330 1.000 31.91627 ? 193 LEU A N   1 
ATOM   1586 C CA  . LEU A 1 193 ? -33.19659  -21.06404 -127.58242 1.000 28.23266 ? 193 LEU A CA  1 
ATOM   1587 C C   . LEU A 1 193 ? -33.70537  -22.46792 -127.25785 1.000 37.27033 ? 193 LEU A C   1 
ATOM   1588 O O   . LEU A 1 193 ? -33.02691  -23.46183 -127.54263 1.000 38.60252 ? 193 LEU A O   1 
ATOM   1589 C CB  . LEU A 1 193 ? -32.66256  -20.37660 -126.33429 1.000 31.70977 ? 193 LEU A CB  1 
ATOM   1590 C CG  . LEU A 1 193 ? -31.81869  -21.32491 -125.49771 1.000 27.82152 ? 193 LEU A CG  1 
ATOM   1591 C CD1 . LEU A 1 193 ? -30.57586  -21.74442 -126.29279 1.000 37.31573 ? 193 LEU A CD1 1 
ATOM   1592 C CD2 . LEU A 1 193 ? -31.45483  -20.68004 -124.18334 1.000 23.75084 ? 193 LEU A CD2 1 
ATOM   1593 N N   . VAL A 1 194 ? -34.90134  -22.57371 -126.66534 1.000 30.43879 ? 194 VAL A N   1 
ATOM   1594 C CA  . VAL A 1 194 ? -35.39855  -23.88490 -126.26002 1.000 30.18395 ? 194 VAL A CA  1 
ATOM   1595 C C   . VAL A 1 194 ? -35.78339  -24.71587 -127.48168 1.000 33.28977 ? 194 VAL A C   1 
ATOM   1596 O O   . VAL A 1 194 ? -35.46921  -25.91045 -127.55707 1.000 28.79581 ? 194 VAL A O   1 
ATOM   1597 C CB  . VAL A 1 194 ? -36.56797  -23.74727 -125.26165 1.000 33.87640 ? 194 VAL A CB  1 
ATOM   1598 C CG1 . VAL A 1 194 ? -37.22555  -25.11176 -125.00716 1.000 31.63731 ? 194 VAL A CG1 1 
ATOM   1599 C CG2 . VAL A 1 194 ? -36.06995  -23.18554 -123.94477 1.000 25.66621 ? 194 VAL A CG2 1 
ATOM   1600 N N   . LYS A 1 195 ? -36.46018  -24.10448 -128.45713 1.000 34.30903 ? 195 LYS A N   1 
ATOM   1601 C CA  . LYS A 1 195 ? -36.74405  -24.80480 -129.70543 1.000 30.11656 ? 195 LYS A CA  1 
ATOM   1602 C C   . LYS A 1 195 ? -35.46874  -25.37559 -130.31029 1.000 33.57893 ? 195 LYS A C   1 
ATOM   1603 O O   . LYS A 1 195 ? -35.42470  -26.53737 -130.73360 1.000 34.24830 ? 195 LYS A O   1 
ATOM   1604 C CB  . LYS A 1 195 ? -37.41040  -23.85803 -130.69302 1.000 30.25421 ? 195 LYS A CB  1 
ATOM   1605 C CG  . LYS A 1 195 ? -37.72306  -24.50474 -132.02949 1.000 40.60820 ? 195 LYS A CG  1 
ATOM   1606 C CD  . LYS A 1 195 ? -38.14837  -23.46367 -133.05833 1.000 41.66097 ? 195 LYS A CD  1 
ATOM   1607 C CE  . LYS A 1 195 ? -38.50193  -24.12264 -134.37833 1.000 45.69067 ? 195 LYS A CE  1 
ATOM   1608 N NZ  . LYS A 1 195 ? -39.72113  -24.96868 -134.22295 1.000 57.27679 ? 195 LYS A NZ  1 
ATOM   1609 N N   . SER A 1 196 ? -34.40925  -24.57077 -130.32869 1.000 31.70112 ? 196 SER A N   1 
ATOM   1610 C CA  . SER A 1 196 ? -33.13045  -25.01796 -130.85310 1.000 31.16653 ? 196 SER A CA  1 
ATOM   1611 C C   . SER A 1 196 ? -32.64627  -26.27989 -130.14444 1.000 40.66986 ? 196 SER A C   1 
ATOM   1612 O O   . SER A 1 196 ? -32.27663  -27.26642 -130.79527 1.000 40.45263 ? 196 SER A O   1 
ATOM   1613 C CB  . SER A 1 196 ? -32.12310  -23.88035 -130.72529 1.000 33.77646 ? 196 SER A CB  1 
ATOM   1614 O OG  . SER A 1 196 ? -30.82312  -24.32800 -131.01954 1.000 53.14992 ? 196 SER A OG  1 
ATOM   1615 N N   . LEU A 1 197 ? -32.66457  -26.27943 -128.80183 1.000 36.59974 ? 197 LEU A N   1 
ATOM   1616 C CA  . LEU A 1 197 ? -32.21030  -27.44605 -128.05041 1.000 35.78383 ? 197 LEU A CA  1 
ATOM   1617 C C   . LEU A 1 197 ? -33.11855  -28.64794 -128.29243 1.000 31.56107 ? 197 LEU A C   1 
ATOM   1618 O O   . LEU A 1 197 ? -32.63793  -29.76099 -128.53512 1.000 30.19297 ? 197 LEU A O   1 
ATOM   1619 C CB  . LEU A 1 197 ? -32.13554  -27.10546 -126.56389 1.000 35.73534 ? 197 LEU A CB  1 
ATOM   1620 C CG  . LEU A 1 197 ? -31.11222  -26.03353 -126.20637 1.000 38.28409 ? 197 LEU A CG  1 
ATOM   1621 C CD1 . LEU A 1 197 ? -31.23706  -25.67129 -124.73661 1.000 29.65601 ? 197 LEU A CD1 1 
ATOM   1622 C CD2 . LEU A 1 197 ? -29.68998  -26.49351 -126.54497 1.000 32.13766 ? 197 LEU A CD2 1 
ATOM   1623 N N   . ARG A 1 198 ? -34.43975  -28.44473 -128.25111 1.000 30.67955 ? 198 ARG A N   1 
ATOM   1624 C CA  . ARG A 1 198 ? -35.36614  -29.54650 -128.49315 1.000 35.87034 ? 198 ARG A CA  1 
ATOM   1625 C C   . ARG A 1 198 ? -35.18578  -30.12114 -129.88940 1.000 35.77160 ? 198 ARG A C   1 
ATOM   1626 O O   . ARG A 1 198 ? -35.22918  -31.34288 -130.07614 1.000 32.15150 ? 198 ARG A O   1 
ATOM   1627 C CB  . ARG A 1 198 ? -36.81248  -29.07986 -128.30675 1.000 33.81296 ? 198 ARG A CB  1 
ATOM   1628 C CG  . ARG A 1 198 ? -37.13016  -28.53769 -126.92632 1.000 41.91156 ? 198 ARG A CG  1 
ATOM   1629 C CD  . ARG A 1 198 ? -37.78343  -29.58130 -126.04101 1.000 40.88790 ? 198 ARG A CD  1 
ATOM   1630 N NE  . ARG A 1 198 ? -39.12821  -29.91975 -126.49992 1.000 47.65410 ? 198 ARG A NE  1 
ATOM   1631 C CZ  . ARG A 1 198 ? -39.85051  -30.92484 -126.01198 1.000 48.85046 ? 198 ARG A CZ  1 
ATOM   1632 N NH1 . ARG A 1 198 ? -39.35744  -31.69560 -125.04834 1.000 49.23771 ? 198 ARG A NH1 1 
ATOM   1633 N NH2 . ARG A 1 198 ? -41.06802  -31.16282 -126.48911 1.000 45.87545 ? 198 ARG A NH2 1 
ATOM   1634 N N   . ASP A 1 199 ? -34.98034  -29.25328 -130.89027 1.000 34.44925 ? 199 ASP A N   1 
ATOM   1635 C CA  . ASP A 1 199 ? -34.80560  -29.71441 -132.26154 1.000 36.53946 ? 199 ASP A CA  1 
ATOM   1636 C C   . ASP A 1 199 ? -33.50192  -30.47808 -132.44683 1.000 36.00538 ? 199 ASP A C   1 
ATOM   1637 O O   . ASP A 1 199 ? -33.33745  -31.14835 -133.46740 1.000 42.06408 ? 199 ASP A O   1 
ATOM   1638 C CB  . ASP A 1 199 ? -34.85409  -28.53581 -133.24651 1.000 34.46645 ? 199 ASP A CB  1 
ATOM   1639 C CG  . ASP A 1 199 ? -36.26957  -27.98946 -133.47006 1.000 35.66593 ? 199 ASP A CG  1 
ATOM   1640 O OD1 . ASP A 1 199 ? -37.26280  -28.60905 -133.02654 1.000 40.17492 ? 199 ASP A OD1 1 
ATOM   1641 O OD2 . ASP A 1 199 ? -36.38642  -26.91051 -134.09194 1.000 41.87608 ? 199 ASP A OD2 1 
ATOM   1642 N N   . LYS A 1 200 ? -32.57708  -30.40007 -131.49457 1.000 31.95024 ? 200 LYS A N   1 
ATOM   1643 C CA  . LYS A 1 200 ? -31.37387  -31.21730 -131.51974 1.000 36.91171 ? 200 LYS A CA  1 
ATOM   1644 C C   . LYS A 1 200 ? -31.47663  -32.44594 -130.60904 1.000 35.02070 ? 200 LYS A C   1 
ATOM   1645 O O   . LYS A 1 200 ? -30.45779  -33.08837 -130.33961 1.000 32.38815 ? 200 LYS A O   1 
ATOM   1646 C CB  . LYS A 1 200 ? -30.16029  -30.37441 -131.12385 1.000 39.78550 ? 200 LYS A CB  1 
ATOM   1647 C CG  . LYS A 1 200 ? -29.72192  -29.35195 -132.16977 1.000 45.01112 ? 200 LYS A CG  1 
ATOM   1648 C CD  . LYS A 1 200 ? -28.98082  -28.18532 -131.50912 1.000 46.36545 ? 200 LYS A CD  1 
ATOM   1649 C CE  . LYS A 1 200 ? -27.47456  -28.41513 -131.52400 1.000 53.24778 ? 200 LYS A CE  1 
ATOM   1650 N NZ  . LYS A 1 200 ? -26.74096  -27.58909 -132.52849 1.000 57.75944 ? 200 LYS A NZ  1 
ATOM   1651 N N   . GLY A 1 201 ? -32.67629  -32.78345 -130.13071 1.000 30.12348 ? 201 GLY A N   1 
ATOM   1652 C CA  . GLY A 1 201 ? -32.84160  -33.92346 -129.24319 1.000 38.85588 ? 201 GLY A CA  1 
ATOM   1653 C C   . GLY A 1 201 ? -32.24208  -33.77347 -127.85779 1.000 39.46739 ? 201 GLY A C   1 
ATOM   1654 O O   . GLY A 1 201 ? -32.03305  -34.78300 -127.16426 1.000 35.83969 ? 201 GLY A O   1 
ATOM   1655 N N   . ILE A 1 202 ? -31.95793  -32.54626 -127.43661 1.000 32.92689 ? 202 ILE A N   1 
ATOM   1656 C CA  . ILE A 1 202 ? -31.41887  -32.29079 -126.09363 1.000 34.10979 ? 202 ILE A CA  1 
ATOM   1657 C C   . ILE A 1 202 ? -32.50966  -32.52148 -125.05123 1.000 33.49994 ? 202 ILE A C   1 
ATOM   1658 O O   . ILE A 1 202 ? -33.63870  -32.01677 -125.20759 1.000 31.11397 ? 202 ILE A O   1 
ATOM   1659 C CB  . ILE A 1 202 ? -30.86965  -30.86963 -126.01018 1.000 36.83008 ? 202 ILE A CB  1 
ATOM   1660 C CG1 . ILE A 1 202 ? -29.72510  -30.70887 -127.00833 1.000 34.45664 ? 202 ILE A CG1 1 
ATOM   1661 C CG2 . ILE A 1 202 ? -30.43378  -30.54045 -124.59180 1.000 32.53962 ? 202 ILE A CG2 1 
ATOM   1662 C CD1 . ILE A 1 202 ? -28.56051  -31.62454 -126.71090 1.000 30.72354 ? 202 ILE A CD1 1 
ATOM   1663 N N   . PRO A 1 203 ? -32.23221  -33.25483 -123.98199 1.000 36.77865 ? 203 PRO A N   1 
ATOM   1664 C CA  . PRO A 1 203 ? -33.28086  -33.54231 -122.99177 1.000 32.13138 ? 203 PRO A CA  1 
ATOM   1665 C C   . PRO A 1 203 ? -33.66474  -32.33910 -122.13782 1.000 30.37152 ? 203 PRO A C   1 
ATOM   1666 O O   . PRO A 1 203 ? -33.33246  -32.29056 -120.94999 1.000 33.87916 ? 203 PRO A O   1 
ATOM   1667 C CB  . PRO A 1 203 ? -32.64559  -34.63874 -122.12765 1.000 24.50278 ? 203 PRO A CB  1 
ATOM   1668 C CG  . PRO A 1 203 ? -31.18653  -34.37759 -122.22002 1.000 28.38106 ? 203 PRO A CG  1 
ATOM   1669 C CD  . PRO A 1 203 ? -30.92951  -33.83291 -123.60281 1.000 26.02173 ? 203 PRO A CD  1 
ATOM   1670 N N   . ILE A 1 204 ? -34.37156  -31.37118 -122.71045 1.000 31.38308 ? 204 ILE A N   1 
ATOM   1671 C CA  . ILE A 1 204 ? -34.93090  -30.26118 -121.95089 1.000 26.87280 ? 204 ILE A CA  1 
ATOM   1672 C C   . ILE A 1 204 ? -36.44433  -30.42713 -121.96821 1.000 34.77006 ? 204 ILE A C   1 
ATOM   1673 O O   . ILE A 1 204 ? -37.06776  -30.36953 -123.03252 1.000 34.71188 ? 204 ILE A O   1 
ATOM   1674 C CB  . ILE A 1 204 ? -34.48492  -28.89961 -122.51348 1.000 27.44999 ? 204 ILE A CB  1 
ATOM   1675 C CG1 . ILE A 1 204 ? -35.29643  -27.75573 -121.89000 1.000 28.47085 ? 204 ILE A CG1 1 
ATOM   1676 C CG2 . ILE A 1 204 ? -34.59516  -28.87722 -124.02558 1.000 37.32534 ? 204 ILE A CG2 1 
ATOM   1677 C CD1 . ILE A 1 204 ? -34.74011  -26.37755 -122.19711 1.000 25.75723 ? 204 ILE A CD1 1 
ATOM   1678 N N   . HIS A 1 205 ? -37.03337  -30.66838 -120.79572 1.000 26.74523 ? 205 HIS A N   1 
ATOM   1679 C CA  . HIS A 1 205 ? -38.44560  -31.02044 -120.70911 1.000 24.34150 ? 205 HIS A CA  1 
ATOM   1680 C C   . HIS A 1 205 ? -39.34205  -29.86008 -120.31343 1.000 28.10373 ? 205 HIS A C   1 
ATOM   1681 O O   . HIS A 1 205 ? -40.56208  -29.95846 -120.47658 1.000 29.89848 ? 205 HIS A O   1 
ATOM   1682 C CB  . HIS A 1 205 ? -38.65593  -32.15554 -119.69429 1.000 26.54144 ? 205 HIS A CB  1 
ATOM   1683 C CG  . HIS A 1 205 ? -37.62978  -33.24156 -119.77916 1.000 32.24374 ? 205 HIS A CG  1 
ATOM   1684 N ND1 . HIS A 1 205 ? -36.41890  -33.17534 -119.12008 1.000 30.94111 ? 205 HIS A ND1 1 
ATOM   1685 C CD2 . HIS A 1 205 ? -37.63781  -34.42669 -120.43493 1.000 31.78041 ? 205 HIS A CD2 1 
ATOM   1686 C CE1 . HIS A 1 205 ? -35.72333  -34.27067 -119.37323 1.000 32.98010 ? 205 HIS A CE1 1 
ATOM   1687 N NE2 . HIS A 1 205 ? -36.43894  -35.04474 -120.17142 1.000 35.98561 ? 205 HIS A NE2 1 
ATOM   1688 N N   . GLY A 1 206 ? -38.78483  -28.77569 -119.78910 1.000 28.81473 ? 206 GLY A N   1 
ATOM   1689 C CA  . GLY A 1 206 ? -39.61938  -27.75443 -119.19111 1.000 31.88172 ? 206 GLY A CA  1 
ATOM   1690 C C   . GLY A 1 206 ? -38.99634  -26.38349 -119.28725 1.000 24.29108 ? 206 GLY A C   1 
ATOM   1691 O O   . GLY A 1 206 ? -37.78022  -26.23223 -119.44017 1.000 27.76054 ? 206 GLY A O   1 
ATOM   1692 N N   . ILE A 1 207 ? -39.86059  -25.37969 -119.22177 1.000 25.41984 ? 207 ILE A N   1 
ATOM   1693 C CA  . ILE A 1 207 ? -39.44672  -23.98781 -119.12888 1.000 29.00759 ? 207 ILE A CA  1 
ATOM   1694 C C   . ILE A 1 207 ? -39.93035  -23.47117 -117.78365 1.000 20.33703 ? 207 ILE A C   1 
ATOM   1695 O O   . ILE A 1 207 ? -41.08300  -23.71307 -117.39274 1.000 21.43324 ? 207 ILE A O   1 
ATOM   1696 C CB  . ILE A 1 207 ? -39.99351  -23.13498 -120.29218 1.000 26.31396 ? 207 ILE A CB  1 
ATOM   1697 C CG1 . ILE A 1 207 ? -39.25148  -23.45682 -121.59091 1.000 27.75623 ? 207 ILE A CG1 1 
ATOM   1698 C CG2 . ILE A 1 207 ? -39.78788  -21.65107 -120.02008 1.000 15.91653 ? 207 ILE A CG2 1 
ATOM   1699 C CD1 . ILE A 1 207 ? -39.89199  -22.82238 -122.84334 1.000 28.42036 ? 207 ILE A CD1 1 
ATOM   1700 N N   . GLY A 1 208 ? -39.03235  -22.82040 -117.05216 1.000 21.19363 ? 208 GLY A N   1 
ATOM   1701 C CA  . GLY A 1 208 ? -39.36063  -22.23881 -115.77975 1.000 21.02918 ? 208 GLY A CA  1 
ATOM   1702 C C   . GLY A 1 208 ? -39.56491  -20.75253 -115.97177 1.000 22.10174 ? 208 GLY A C   1 
ATOM   1703 O O   . GLY A 1 208 ? -38.65140  -20.03612 -116.38740 1.000 20.83135 ? 208 GLY A O   1 
ATOM   1704 N N   . MET A 1 209 ? -40.77449  -20.29970 -115.68459 1.000 22.48126 ? 209 MET A N   1 
ATOM   1705 C CA  . MET A 1 209 ? -41.10680  -18.88510 -115.72955 1.000 23.92926 ? 209 MET A CA  1 
ATOM   1706 C C   . MET A 1 209 ? -40.91581  -18.33307 -114.32173 1.000 20.42109 ? 209 MET A C   1 
ATOM   1707 O O   . MET A 1 209 ? -41.66824  -18.68357 -113.41013 1.000 20.42554 ? 209 MET A O   1 
ATOM   1708 C CB  . MET A 1 209 ? -42.53963  -18.69447 -116.23272 1.000 19.09819 ? 209 MET A CB  1 
ATOM   1709 C CG  . MET A 1 209 ? -42.77194  -19.25862 -117.65347 1.000 20.30374 ? 209 MET A CG  1 
ATOM   1710 S SD  . MET A 1 209 ? -44.48733  -19.18075 -118.22971 1.000 23.08236 ? 209 MET A SD  1 
ATOM   1711 C CE  . MET A 1 209 ? -44.77324  -17.40830 -118.18650 1.000 17.97795 ? 209 MET A CE  1 
ATOM   1712 N N   . GLN A 1 210 ? -39.89670  -17.48930 -114.12958 1.000 16.79908 ? 210 GLN A N   1 
ATOM   1713 C CA  . GLN A 1 210 ? -39.62700  -17.02139 -112.77178 1.000 21.88228 ? 210 GLN A CA  1 
ATOM   1714 C C   . GLN A 1 210 ? -40.77376  -16.15653 -112.25161 1.000 26.58504 ? 210 GLN A C   1 
ATOM   1715 O O   . GLN A 1 210 ? -41.12708  -16.24447 -111.07579 1.000 21.24135 ? 210 GLN A O   1 
ATOM   1716 C CB  . GLN A 1 210 ? -38.28826  -16.27815 -112.70072 1.000 26.11406 ? 210 GLN A CB  1 
ATOM   1717 C CG  . GLN A 1 210 ? -37.03596  -17.20313 -112.63110 1.000 18.10331 ? 210 GLN A CG  1 
ATOM   1718 C CD  . GLN A 1 210 ? -35.74440  -16.43650 -112.41825 1.000 21.81208 ? 210 GLN A CD  1 
ATOM   1719 O OE1 . GLN A 1 210 ? -35.71214  -15.41492 -111.72642 1.000 21.50687 ? 210 GLN A OE1 1 
ATOM   1720 N NE2 . GLN A 1 210 ? -34.66383  -16.92360 -113.02181 1.000 22.20428 ? 210 GLN A NE2 1 
ATOM   1721 N N   . ALA A 1 211 ? -41.39480  -15.34423 -113.11242 1.000 22.12928 ? 211 ALA A N   1 
ATOM   1722 C CA  . ALA A 1 211 ? -42.52328  -14.49803 -112.71493 1.000 21.73081 ? 211 ALA A CA  1 
ATOM   1723 C C   . ALA A 1 211 ? -42.18011  -13.59174 -111.52452 1.000 24.11231 ? 211 ALA A C   1 
ATOM   1724 O O   . ALA A 1 211 ? -42.93130  -13.49495 -110.54809 1.000 24.45688 ? 211 ALA A O   1 
ATOM   1725 C CB  . ALA A 1 211 ? -43.77458  -15.33681 -112.41931 1.000 14.65358 ? 211 ALA A CB  1 
ATOM   1726 N N   . HIS A 1 212 ? -41.03604  -12.90943 -111.61318 1.000 25.71133 ? 212 HIS A N   1 
ATOM   1727 C CA  . HIS A 1 212 ? -40.71279  -11.82678 -110.68099 1.000 24.68174 ? 212 HIS A CA  1 
ATOM   1728 C C   . HIS A 1 212 ? -41.36815  -10.56612 -111.23599 1.000 24.45609 ? 212 HIS A C   1 
ATOM   1729 O O   . HIS A 1 212 ? -40.75468  -9.74283  -111.92762 1.000 26.13688 ? 212 HIS A O   1 
ATOM   1730 C CB  . HIS A 1 212 ? -39.20470  -11.68166 -110.50472 1.000 18.70101 ? 212 HIS A CB  1 
ATOM   1731 C CG  . HIS A 1 212 ? -38.58560  -12.81988 -109.75561 1.000 22.76481 ? 212 HIS A CG  1 
ATOM   1732 N ND1 . HIS A 1 212 ? -39.00911  -13.19985 -108.49898 1.000 26.78203 ? 212 HIS A ND1 1 
ATOM   1733 C CD2 . HIS A 1 212 ? -37.59989  -13.68333 -110.09561 1.000 24.36693 ? 212 HIS A CD2 1 
ATOM   1734 C CE1 . HIS A 1 212 ? -38.30079  -14.23898 -108.09225 1.000 21.16982 ? 212 HIS A CE1 1 
ATOM   1735 N NE2 . HIS A 1 212 ? -37.43430  -14.54521 -109.03889 1.000 22.07543 ? 212 HIS A NE2 1 
ATOM   1736 N N   . TRP A 1 213 ? -42.65468  -10.44091 -110.92446 1.000 22.33695 ? 213 TRP A N   1 
ATOM   1737 C CA  . TRP A 1 213 ? -43.58549  -9.53625  -111.57762 1.000 22.61164 ? 213 TRP A CA  1 
ATOM   1738 C C   . TRP A 1 213 ? -43.86497  -8.31150  -110.71598 1.000 28.88612 ? 213 TRP A C   1 
ATOM   1739 O O   . TRP A 1 213 ? -43.51923  -8.25188  -109.52949 1.000 27.87412 ? 213 TRP A O   1 
ATOM   1740 C CB  . TRP A 1 213 ? -44.88968  -10.27889 -111.88557 1.000 22.14690 ? 213 TRP A CB  1 
ATOM   1741 C CG  . TRP A 1 213 ? -44.70893  -11.29656 -112.97628 1.000 20.95866 ? 213 TRP A CG  1 
ATOM   1742 C CD1 . TRP A 1 213 ? -43.64220  -11.39407 -113.83162 1.000 19.88437 ? 213 TRP A CD1 1 
ATOM   1743 C CD2 . TRP A 1 213 ? -45.61938  -12.34070 -113.34610 1.000 21.48054 ? 213 TRP A CD2 1 
ATOM   1744 N NE1 . TRP A 1 213 ? -43.84421  -12.42135 -114.72217 1.000 24.53709 ? 213 TRP A NE1 1 
ATOM   1745 C CE2 . TRP A 1 213 ? -45.04288  -13.02461 -114.44156 1.000 21.94730 ? 213 TRP A CE2 1 
ATOM   1746 C CE3 . TRP A 1 213 ? -46.87284  -12.75722 -112.86858 1.000 21.13417 ? 213 TRP A CE3 1 
ATOM   1747 C CZ2 . TRP A 1 213 ? -45.65894  -14.11153 -115.04576 1.000 17.79642 ? 213 TRP A CZ2 1 
ATOM   1748 C CZ3 . TRP A 1 213 ? -47.47789  -13.85126 -113.46224 1.000 19.15901 ? 213 TRP A CZ3 1 
ATOM   1749 C CH2 . TRP A 1 213 ? -46.87567  -14.51396 -114.54434 1.000 21.25249 ? 213 TRP A CH2 1 
ATOM   1750 N N   . SER A 1 214 ? -44.49670  -7.32098  -111.33663 1.000 24.05727 ? 214 SER A N   1 
ATOM   1751 C CA  . SER A 1 214 ? -44.92768  -6.10461  -110.66053 1.000 21.59821 ? 214 SER A CA  1 
ATOM   1752 C C   . SER A 1 214 ? -46.45177  -6.00045  -110.76247 1.000 27.95149 ? 214 SER A C   1 
ATOM   1753 O O   . SER A 1 214 ? -47.12668  -6.90115  -111.28322 1.000 26.27634 ? 214 SER A O   1 
ATOM   1754 C CB  . SER A 1 214 ? -44.22015  -4.88433  -111.25439 1.000 22.83804 ? 214 SER A CB  1 
ATOM   1755 O OG  . SER A 1 214 ? -44.80981  -4.49387  -112.48874 1.000 27.99920 ? 214 SER A OG  1 
ATOM   1756 N N   . LEU A 1 215 ? -47.01364  -4.90214  -110.24489 1.000 30.63820 ? 215 LEU A N   1 
ATOM   1757 C CA  . LEU A 1 215 ? -48.46645  -4.73278  -110.31963 1.000 29.64464 ? 215 LEU A CA  1 
ATOM   1758 C C   . LEU A 1 215 ? -48.92999  -4.53365  -111.75747 1.000 28.71977 ? 215 LEU A C   1 
ATOM   1759 O O   . LEU A 1 215 ? -50.02804  -4.96296  -112.11878 1.000 28.35320 ? 215 LEU A O   1 
ATOM   1760 C CB  . LEU A 1 215 ? -48.90404  -3.56104  -109.44033 1.000 28.99695 ? 215 LEU A CB  1 
ATOM   1761 C CG  . LEU A 1 215 ? -48.76515  -3.83974  -107.94246 1.000 25.92880 ? 215 LEU A CG  1 
ATOM   1762 C CD1 . LEU A 1 215 ? -49.02427  -2.62351  -107.08699 1.000 25.62456 ? 215 LEU A CD1 1 
ATOM   1763 C CD2 . LEU A 1 215 ? -49.74144  -4.93189  -107.57646 1.000 26.91395 ? 215 LEU A CD2 1 
ATOM   1764 N N   . THR A 1 216 ? -48.08296  -3.93632  -112.59452 1.000 29.65530 ? 216 THR A N   1 
ATOM   1765 C CA  . THR A 1 216 ? -48.41239  -3.57033  -113.96297 1.000 31.81661 ? 216 THR A CA  1 
ATOM   1766 C C   . THR A 1 216 ? -47.79646  -4.48330  -115.01359 1.000 32.24985 ? 216 THR A C   1 
ATOM   1767 O O   . THR A 1 216 ? -48.42625  -4.71966  -116.04980 1.000 28.02828 ? 216 THR A O   1 
ATOM   1768 C CB  . THR A 1 216 ? -47.96125  -2.12763  -114.23546 1.000 26.96041 ? 216 THR A CB  1 
ATOM   1769 O OG1 . THR A 1 216 ? -48.59378  -1.25679  -113.30008 1.000 30.56244 ? 216 THR A OG1 1 
ATOM   1770 C CG2 . THR A 1 216 ? -48.33043  -1.69142  -115.63685 1.000 26.89032 ? 216 THR A CG2 1 
ATOM   1771 N N   . ARG A 1 217 ? -46.59242  -5.00918  -114.76749 1.000 26.01526 ? 217 ARG A N   1 
ATOM   1772 C CA  . ARG A 1 217 ? -45.78685  -5.71813  -115.76053 1.000 28.33078 ? 217 ARG A CA  1 
ATOM   1773 C C   . ARG A 1 217 ? -45.50923  -7.15461  -115.33371 1.000 28.39164 ? 217 ARG A C   1 
ATOM   1774 O O   . ARG A 1 217 ? -45.23766  -7.41342  -114.15713 1.000 33.34572 ? 217 ARG A O   1 
ATOM   1775 C CB  . ARG A 1 217 ? -44.44182  -5.01169  -115.98963 1.000 21.44340 ? 217 ARG A CB  1 
ATOM   1776 C CG  . ARG A 1 217 ? -44.54543  -3.57198  -116.39584 1.000 25.39021 ? 217 ARG A CG  1 
ATOM   1777 C CD  . ARG A 1 217 ? -43.26536  -3.17342  -117.04230 1.000 26.85291 ? 217 ARG A CD  1 
ATOM   1778 N NE  . ARG A 1 217 ? -43.18845  -3.75755  -118.37087 1.000 32.57009 ? 217 ARG A NE  1 
ATOM   1779 C CZ  . ARG A 1 217 ? -42.18620  -3.56138  -119.21384 1.000 31.76826 ? 217 ARG A CZ  1 
ATOM   1780 N NH1 . ARG A 1 217 ? -41.15864  -2.79589  -118.86102 1.000 27.75401 ? 217 ARG A NH1 1 
ATOM   1781 N NH2 . ARG A 1 217 ? -42.21318  -4.13057  -120.40835 1.000 28.43943 ? 217 ARG A NH2 1 
ATOM   1782 N N   . PRO A 1 218 ? -45.57469  -8.11147  -116.25987 1.000 27.79210 ? 218 PRO A N   1 
ATOM   1783 C CA  . PRO A 1 218 ? -46.09550  -7.94870  -117.62018 1.000 24.12483 ? 218 PRO A CA  1 
ATOM   1784 C C   . PRO A 1 218 ? -47.63196  -7.90800  -117.60911 1.000 28.47649 ? 218 PRO A C   1 
ATOM   1785 O O   . PRO A 1 218 ? -48.24659  -8.22635  -116.57934 1.000 29.44560 ? 218 PRO A O   1 
ATOM   1786 C CB  . PRO A 1 218 ? -45.59042  -9.20151  -118.33620 1.000 26.40401 ? 218 PRO A CB  1 
ATOM   1787 C CG  . PRO A 1 218 ? -45.52432  -10.22704 -117.25484 1.000 27.13896 ? 218 PRO A CG  1 
ATOM   1788 C CD  . PRO A 1 218 ? -45.08582  -9.47910  -116.01555 1.000 22.94475 ? 218 PRO A CD  1 
ATOM   1789 N N   . SER A 1 219 ? -48.24457  -7.51908  -118.72506 1.000 25.78065 ? 219 SER A N   1 
ATOM   1790 C CA  . SER A 1 219 ? -49.70098  -7.51469  -118.81122 1.000 28.89915 ? 219 SER A CA  1 
ATOM   1791 C C   . SER A 1 219 ? -50.23618  -8.93843  -118.85532 1.000 24.75222 ? 219 SER A C   1 
ATOM   1792 O O   . SER A 1 219 ? -49.52634  -9.88965  -119.20807 1.000 27.21355 ? 219 SER A O   1 
ATOM   1793 C CB  . SER A 1 219 ? -50.16428  -6.76853  -120.05474 1.000 20.99188 ? 219 SER A CB  1 
ATOM   1794 O OG  . SER A 1 219 ? -49.79988  -7.49633  -121.21545 1.000 28.59800 ? 219 SER A OG  1 
ATOM   1795 N N   . LEU A 1 220 ? -51.51466  -9.07845  -118.50726 1.000 28.07487 ? 220 LEU A N   1 
ATOM   1796 C CA  . LEU A 1 220 ? -52.15433  -10.38067 -118.63217 1.000 26.19112 ? 220 LEU A CA  1 
ATOM   1797 C C   . LEU A 1 220 ? -52.06421  -10.90735 -120.05551 1.000 28.82099 ? 220 LEU A C   1 
ATOM   1798 O O   . LEU A 1 220 ? -52.00550  -12.12330 -120.25776 1.000 29.94716 ? 220 LEU A O   1 
ATOM   1799 C CB  . LEU A 1 220 ? -53.61562  -10.30637 -118.20005 1.000 25.34144 ? 220 LEU A CB  1 
ATOM   1800 C CG  . LEU A 1 220 ? -53.96273  -10.12177 -116.72995 1.000 37.06652 ? 220 LEU A CG  1 
ATOM   1801 C CD1 . LEU A 1 220 ? -55.48454  -10.04208 -116.64077 1.000 26.06368 ? 220 LEU A CD1 1 
ATOM   1802 C CD2 . LEU A 1 220 ? -53.40778  -11.26277 -115.84917 1.000 26.50305 ? 220 LEU A CD2 1 
ATOM   1803 N N   . ASP A 1 221 ? -52.05058  -10.01514 -121.05286 1.000 28.96319 ? 221 ASP A N   1 
ATOM   1804 C CA  . ASP A 1 221 ? -51.94857  -10.46141 -122.44223 1.000 27.17045 ? 221 ASP A CA  1 
ATOM   1805 C C   . ASP A 1 221 ? -50.54808  -10.97543 -122.75138 1.000 31.18665 ? 221 ASP A C   1 
ATOM   1806 O O   . ASP A 1 221 ? -50.39186  -11.95932 -123.48349 1.000 33.98336 ? 221 ASP A O   1 
ATOM   1807 C CB  . ASP A 1 221 ? -52.31939  -9.32381  -123.39816 1.000 31.83423 ? 221 ASP A CB  1 
ATOM   1808 C CG  . ASP A 1 221 ? -53.83404  -9.15456  -123.57516 1.000 39.29330 ? 221 ASP A CG  1 
ATOM   1809 O OD1 . ASP A 1 221 ? -54.61800  -9.98850  -123.05195 1.000 34.76640 ? 221 ASP A OD1 1 
ATOM   1810 O OD2 . ASP A 1 221 ? -54.23155  -8.16688  -124.23926 1.000 41.29154 ? 221 ASP A OD2 1 
ATOM   1811 N N   . GLU A 1 222 ? -49.51486  -10.31871 -122.21134 1.000 29.87497 ? 222 GLU A N   1 
ATOM   1812 C CA  . GLU A 1 222 ? -48.15656  -10.82512 -122.38430 1.000 29.00015 ? 222 GLU A CA  1 
ATOM   1813 C C   . GLU A 1 222 ? -47.96614  -12.15967 -121.66825 1.000 24.89328 ? 222 GLU A C   1 
ATOM   1814 O O   . GLU A 1 222 ? -47.28452  -13.04825 -122.18402 1.000 29.18234 ? 222 GLU A O   1 
ATOM   1815 C CB  . GLU A 1 222 ? -47.13715  -9.79301  -121.89889 1.000 27.49264 ? 222 GLU A CB  1 
ATOM   1816 C CG  . GLU A 1 222 ? -47.17181  -8.49839  -122.69597 1.000 29.16337 ? 222 GLU A CG  1 
ATOM   1817 C CD  . GLU A 1 222 ? -46.24214  -7.42109  -122.13700 1.000 34.27104 ? 222 GLU A CD  1 
ATOM   1818 O OE1 . GLU A 1 222 ? -46.07644  -7.34664  -120.89855 1.000 31.33416 ? 222 GLU A OE1 1 
ATOM   1819 O OE2 . GLU A 1 222 ? -45.70662  -6.61864  -122.93633 1.000 36.22818 ? 222 GLU A OE2 1 
ATOM   1820 N N   . ILE A 1 223 ? -48.55894  -12.32802 -120.48731 1.000 23.79006 ? 223 ILE A N   1 
ATOM   1821 C CA  . ILE A 1 223 ? -48.45641  -13.61222 -119.79450 1.000 24.11520 ? 223 ILE A CA  1 
ATOM   1822 C C   . ILE A 1 223 ? -49.14061  -14.71113 -120.60341 1.000 27.17222 ? 223 ILE A C   1 
ATOM   1823 O O   . ILE A 1 223 ? -48.58086  -15.79497 -120.81314 1.000 25.26592 ? 223 ILE A O   1 
ATOM   1824 C CB  . ILE A 1 223 ? -49.06096  -13.51927 -118.38399 1.000 23.50046 ? 223 ILE A CB  1 
ATOM   1825 C CG1 . ILE A 1 223 ? -48.38222  -12.42738 -117.55863 1.000 22.07928 ? 223 ILE A CG1 1 
ATOM   1826 C CG2 . ILE A 1 223 ? -48.98849  -14.86181 -117.69542 1.000 20.32320 ? 223 ILE A CG2 1 
ATOM   1827 C CD1 . ILE A 1 223 ? -49.12976  -12.12663 -116.27698 1.000 21.67295 ? 223 ILE A CD1 1 
ATOM   1828 N N   . ARG A 1 224 ? -50.37503  -14.45834 -121.04722 1.000 29.29685 ? 224 ARG A N   1 
ATOM   1829 C CA  . ARG A 1 224 ? -51.08733  -15.43396 -121.87536 1.000 27.12030 ? 224 ARG A CA  1 
ATOM   1830 C C   . ARG A 1 224 ? -50.27914  -15.80988 -123.11344 1.000 23.25072 ? 224 ARG A C   1 
ATOM   1831 O O   . ARG A 1 224 ? -50.15602  -16.99215 -123.45361 1.000 25.38521 ? 224 ARG A O   1 
ATOM   1832 C CB  . ARG A 1 224 ? -52.45554  -14.87482 -122.27537 1.000 22.86920 ? 224 ARG A CB  1 
ATOM   1833 C CG  . ARG A 1 224 ? -53.26022  -15.76804 -123.20673 1.000 30.31884 ? 224 ARG A CG  1 
ATOM   1834 C CD  . ARG A 1 224 ? -54.56171  -15.10586 -123.64253 1.000 26.37998 ? 224 ARG A CD  1 
ATOM   1835 N NE  . ARG A 1 224 ? -55.45446  -14.73668 -122.54018 1.000 26.87991 ? 224 ARG A NE  1 
ATOM   1836 C CZ  . ARG A 1 224 ? -56.31004  -15.57843 -121.96856 1.000 25.90108 ? 224 ARG A CZ  1 
ATOM   1837 N NH1 . ARG A 1 224 ? -56.35260  -16.83351 -122.37313 1.000 24.10263 ? 224 ARG A NH1 1 
ATOM   1838 N NH2 . ARG A 1 224 ? -57.10374  -15.18441 -120.98059 1.000 21.13232 ? 224 ARG A NH2 1 
ATOM   1839 N N   . ALA A 1 225 ? -49.68564  -14.82062 -123.77987 1.000 24.54505 ? 225 ALA A N   1 
ATOM   1840 C CA  . ALA A 1 225 ? -48.95499  -15.10766 -125.01029 1.000 31.33006 ? 225 ALA A CA  1 
ATOM   1841 C C   . ALA A 1 225 ? -47.69523  -15.92268 -124.73000 1.000 30.23836 ? 225 ALA A C   1 
ATOM   1842 O O   . ALA A 1 225 ? -47.32895  -16.80677 -125.51781 1.000 31.27609 ? 225 ALA A O   1 
ATOM   1843 C CB  . ALA A 1 225 ? -48.61072  -13.80287 -125.73307 1.000 22.78834 ? 225 ALA A CB  1 
ATOM   1844 N N   . ALA A 1 226 ? -47.01785  -15.63599 -123.61608 1.000 29.86811 ? 226 ALA A N   1 
ATOM   1845 C CA  . ALA A 1 226 ? -45.80679  -16.37479 -123.26648 1.000 24.27369 ? 226 ALA A CA  1 
ATOM   1846 C C   . ALA A 1 226 ? -46.13768  -17.82822 -122.96526 1.000 24.71975 ? 226 ALA A C   1 
ATOM   1847 O O   . ALA A 1 226 ? -45.49296  -18.74321 -123.49380 1.000 25.31269 ? 226 ALA A O   1 
ATOM   1848 C CB  . ALA A 1 226 ? -45.11786  -15.72075 -122.06861 1.000 20.41960 ? 226 ALA A CB  1 
ATOM   1849 N N   . ILE A 1 227 ? -47.15302  -18.05236 -122.11732 1.000 21.32525 ? 227 ILE A N   1 
ATOM   1850 C CA  . ILE A 1 227 ? -47.61395  -19.40658 -121.81571 1.000 24.11243 ? 227 ILE A CA  1 
ATOM   1851 C C   . ILE A 1 227 ? -47.87814  -20.18034 -123.09605 1.000 24.81253 ? 227 ILE A C   1 
ATOM   1852 O O   . ILE A 1 227 ? -47.39882  -21.30257 -123.26936 1.000 28.56855 ? 227 ILE A O   1 
ATOM   1853 C CB  . ILE A 1 227 ? -48.87248  -19.37006 -120.92998 1.000 25.30311 ? 227 ILE A CB  1 
ATOM   1854 C CG1 . ILE A 1 227 ? -48.55288  -18.81510 -119.54335 1.000 20.14582 ? 227 ILE A CG1 1 
ATOM   1855 C CG2 . ILE A 1 227 ? -49.50747  -20.75872 -120.82159 1.000 23.98993 ? 227 ILE A CG2 1 
ATOM   1856 C CD1 . ILE A 1 227 ? -49.78258  -18.45213 -118.77166 1.000 22.18671 ? 227 ILE A CD1 1 
ATOM   1857 N N   . GLU A 1 228 ? -48.63437  -19.57991 -124.02537 1.000 28.71333 ? 228 GLU A N   1 
ATOM   1858 C CA  . GLU A 1 228 ? -48.96558  -20.27285 -125.26759 1.000 30.97145 ? 228 GLU A CA  1 
ATOM   1859 C C   . GLU A 1 228 ? -47.73374  -20.46649 -126.13573 1.000 30.92057 ? 228 GLU A C   1 
ATOM   1860 O O   . GLU A 1 228 ? -47.54942  -21.53570 -126.72931 1.000 32.12545 ? 228 GLU A O   1 
ATOM   1861 C CB  . GLU A 1 228 ? -50.05048  -19.50995 -126.02172 1.000 30.57838 ? 228 GLU A CB  1 
ATOM   1862 C CG  . GLU A 1 228 ? -51.35772  -19.55718 -125.31909 1.000 34.68832 ? 228 GLU A CG  1 
ATOM   1863 C CD  . GLU A 1 228 ? -52.45634  -19.07518 -126.19643 1.000 43.23178 ? 228 GLU A CD  1 
ATOM   1864 O OE1 . GLU A 1 228 ? -52.11614  -18.51823 -127.26277 1.000 47.54103 ? 228 GLU A OE1 1 
ATOM   1865 O OE2 . GLU A 1 228 ? -53.64854  -19.27379 -125.84495 1.000 31.46232 ? 228 GLU A OE2 1 
ATOM   1866 N N   . ARG A 1 229 ? -46.86028  -19.45675 -126.20801 1.000 23.97312 ? 229 ARG A N   1 
ATOM   1867 C CA  . ARG A 1 229 ? -45.65543  -19.59877 -127.01236 1.000 27.64341 ? 229 ARG A CA  1 
ATOM   1868 C C   . ARG A 1 229 ? -44.76977  -20.70638 -126.46871 1.000 30.92714 ? 229 ARG A C   1 
ATOM   1869 O O   . ARG A 1 229 ? -44.25248  -21.53319 -127.22982 1.000 30.33825 ? 229 ARG A O   1 
ATOM   1870 C CB  . ARG A 1 229 ? -44.90885  -18.26753 -127.06772 1.000 28.87782 ? 229 ARG A CB  1 
ATOM   1871 C CG  . ARG A 1 229 ? -43.75164  -18.21790 -128.07106 1.000 29.13596 ? 229 ARG A CG  1 
ATOM   1872 C CD  . ARG A 1 229 ? -44.22595  -18.30534 -129.50939 1.000 32.34066 ? 229 ARG A CD  1 
ATOM   1873 N NE  . ARG A 1 229 ? -43.25259  -17.73087 -130.43547 1.000 30.73302 ? 229 ARG A NE  1 
ATOM   1874 C CZ  . ARG A 1 229 ? -43.11261  -18.12876 -131.69211 1.000 32.35243 ? 229 ARG A CZ  1 
ATOM   1875 N NH1 . ARG A 1 229 ? -43.85321  -19.13253 -132.13937 1.000 31.87506 ? 229 ARG A NH1 1 
ATOM   1876 N NH2 . ARG A 1 229 ? -42.21091  -17.56071 -132.48575 1.000 29.53435 ? 229 ARG A NH2 1 
ATOM   1877 N N   . TYR A 1 230 ? -44.59743  -20.75538 -125.14539 1.000 30.44349 ? 230 TYR A N   1 
ATOM   1878 C CA  . TYR A 1 230 ? -43.78394  -21.80484 -124.55585 1.000 26.83089 ? 230 TYR A CA  1 
ATOM   1879 C C   . TYR A 1 230 ? -44.48941  -23.15634 -124.64556 1.000 28.91674 ? 230 TYR A C   1 
ATOM   1880 O O   . TYR A 1 230 ? -43.86566  -24.15625 -125.01429 1.000 31.84635 ? 230 TYR A O   1 
ATOM   1881 C CB  . TYR A 1 230 ? -43.44643  -21.44625 -123.11067 1.000 27.42237 ? 230 TYR A CB  1 
ATOM   1882 C CG  . TYR A 1 230 ? -42.60644  -20.19136 -122.97089 1.000 23.01917 ? 230 TYR A CG  1 
ATOM   1883 C CD1 . TYR A 1 230 ? -41.65314  -19.87108 -123.92002 1.000 21.84652 ? 230 TYR A CD1 1 
ATOM   1884 C CD2 . TYR A 1 230 ? -42.76562  -19.32836 -121.87685 1.000 23.60286 ? 230 TYR A CD2 1 
ATOM   1885 C CE1 . TYR A 1 230 ? -40.86718  -18.71212 -123.79270 1.000 17.95681 ? 230 TYR A CE1 1 
ATOM   1886 C CE2 . TYR A 1 230 ? -41.99399  -18.16701 -121.74419 1.000 19.03358 ? 230 TYR A CE2 1 
ATOM   1887 C CZ  . TYR A 1 230 ? -41.05562  -17.87276 -122.70701 1.000 24.46535 ? 230 TYR A CZ  1 
ATOM   1888 O OH  . TYR A 1 230 ? -40.30343  -16.74028 -122.58628 1.000 22.12942 ? 230 TYR A OH  1 
ATOM   1889 N N   . ALA A 1 231 ? -45.79185  -23.20519 -124.32784 1.000 24.48810 ? 231 ALA A N   1 
ATOM   1890 C CA  . ALA A 1 231 ? -46.53285  -24.46396 -124.40986 1.000 29.12000 ? 231 ALA A CA  1 
ATOM   1891 C C   . ALA A 1 231 ? -46.49737  -25.05527 -125.81511 1.000 30.66333 ? 231 ALA A C   1 
ATOM   1892 O O   . ALA A 1 231 ? -46.53472  -26.28108 -125.96971 1.000 32.79668 ? 231 ALA A O   1 
ATOM   1893 C CB  . ALA A 1 231 ? -47.99433  -24.27334 -123.96512 1.000 27.34471 ? 231 ALA A CB  1 
ATOM   1894 N N   . SER A 1 232 ? -46.42615  -24.21325 -126.85151 1.000 35.19131 ? 232 SER A N   1 
ATOM   1895 C CA  . SER A 1 232 ? -46.41188  -24.72509 -128.22474 1.000 30.27315 ? 232 SER A CA  1 
ATOM   1896 C C   . SER A 1 232 ? -45.16988  -25.56633 -128.52550 1.000 32.68844 ? 232 SER A C   1 
ATOM   1897 O O   . SER A 1 232 ? -45.16355  -26.30022 -129.51820 1.000 32.04189 ? 232 SER A O   1 
ATOM   1898 C CB  . SER A 1 232 ? -46.54783  -23.55997 -129.22051 1.000 25.22945 ? 232 SER A CB  1 
ATOM   1899 O OG  . SER A 1 232 ? -45.32258  -22.85354 -129.40810 1.000 30.05256 ? 232 SER A OG  1 
ATOM   1900 N N   . LEU A 1 233 ? -44.13003  -25.49962 -127.68704 1.000 32.92212 ? 233 LEU A N   1 
ATOM   1901 C CA  . LEU A 1 233 ? -42.94266  -26.31949 -127.89381 1.000 25.80023 ? 233 LEU A CA  1 
ATOM   1902 C C   . LEU A 1 233 ? -43.11321  -27.74331 -127.36443 1.000 29.01590 ? 233 LEU A C   1 
ATOM   1903 O O   . LEU A 1 233 ? -42.23496  -28.58322 -127.58846 1.000 37.38387 ? 233 LEU A O   1 
ATOM   1904 C CB  . LEU A 1 233 ? -41.72576  -25.67075 -127.22669 1.000 27.49317 ? 233 LEU A CB  1 
ATOM   1905 C CG  . LEU A 1 233 ? -41.17501  -24.38944 -127.85741 1.000 31.09798 ? 233 LEU A CG  1 
ATOM   1906 C CD1 . LEU A 1 233 ? -40.06056  -23.77488 -126.99953 1.000 22.51652 ? 233 LEU A CD1 1 
ATOM   1907 C CD2 . LEU A 1 233 ? -40.65735  -24.66853 -129.26065 1.000 35.54360 ? 233 LEU A CD2 1 
ATOM   1908 N N   . GLY A 1 234 ? -44.22025  -28.03925 -126.68793 1.000 23.76947 ? 234 GLY A N   1 
ATOM   1909 C CA  . GLY A 1 234 ? -44.41818  -29.32947 -126.07413 1.000 27.47160 ? 234 GLY A CA  1 
ATOM   1910 C C   . GLY A 1 234 ? -43.70422  -29.51689 -124.75480 1.000 37.20811 ? 234 GLY A C   1 
ATOM   1911 O O   . GLY A 1 234 ? -43.64469  -30.64950 -124.25755 1.000 37.19393 ? 234 GLY A O   1 
ATOM   1912 N N   . VAL A 1 235 ? -43.14814  -28.44331 -124.17606 1.000 34.29096 ? 235 VAL A N   1 
ATOM   1913 C CA  . VAL A 1 235 ? -42.51905  -28.52493 -122.86448 1.000 25.96867 ? 235 VAL A CA  1 
ATOM   1914 C C   . VAL A 1 235 ? -43.56744  -28.35750 -121.77132 1.000 28.36202 ? 235 VAL A C   1 
ATOM   1915 O O   . VAL A 1 235 ? -44.65258  -27.81328 -121.98163 1.000 30.59475 ? 235 VAL A O   1 
ATOM   1916 C CB  . VAL A 1 235 ? -41.41627  -27.46779 -122.72181 1.000 31.57898 ? 235 VAL A CB  1 
ATOM   1917 C CG1 . VAL A 1 235 ? -40.32312  -27.70350 -123.73725 1.000 30.91718 ? 235 VAL A CG1 1 
ATOM   1918 C CG2 . VAL A 1 235 ? -41.99807  -26.07550 -122.87078 1.000 32.58302 ? 235 VAL A CG2 1 
ATOM   1919 N N   . VAL A 1 236 ? -43.23229  -28.80928 -120.56384 1.000 31.87380 ? 236 VAL A N   1 
ATOM   1920 C CA  . VAL A 1 236 ? -44.07346  -28.46598 -119.42716 1.000 25.55035 ? 236 VAL A CA  1 
ATOM   1921 C C   . VAL A 1 236 ? -43.63453  -27.11378 -118.88848 1.000 23.46079 ? 236 VAL A C   1 
ATOM   1922 O O   . VAL A 1 236 ? -42.47920  -26.69548 -119.06029 1.000 29.61912 ? 236 VAL A O   1 
ATOM   1923 C CB  . VAL A 1 236 ? -44.01347  -29.54867 -118.33303 1.000 33.07541 ? 236 VAL A CB  1 
ATOM   1924 C CG1 . VAL A 1 236 ? -44.09899  -30.91356 -118.96453 1.000 46.45809 ? 236 VAL A CG1 1 
ATOM   1925 C CG2 . VAL A 1 236 ? -42.78066  -29.41580 -117.48940 1.000 28.50534 ? 236 VAL A CG2 1 
ATOM   1926 N N   . LEU A 1 237 ? -44.56046  -26.43525 -118.21462 1.000 23.34546 ? 237 LEU A N   1 
ATOM   1927 C CA  . LEU A 1 237 ? -44.37314  -25.09967 -117.67345 1.000 24.81036 ? 237 LEU A CA  1 
ATOM   1928 C C   . LEU A 1 237 ? -44.44055  -25.15014 -116.15265 1.000 23.96816 ? 237 LEU A C   1 
ATOM   1929 O O   . LEU A 1 237 ? -45.42574  -25.64899 -115.59153 1.000 23.30754 ? 237 LEU A O   1 
ATOM   1930 C CB  . LEU A 1 237 ? -45.45380  -24.15270 -118.20568 1.000 22.35578 ? 237 LEU A CB  1 
ATOM   1931 C CG  . LEU A 1 237 ? -45.36030  -23.79736 -119.67895 1.000 29.19496 ? 237 LEU A CG  1 
ATOM   1932 C CD1 . LEU A 1 237 ? -46.37597  -22.71150 -120.08488 1.000 20.03344 ? 237 LEU A CD1 1 
ATOM   1933 C CD2 . LEU A 1 237 ? -43.94716  -23.36022 -119.94795 1.000 25.70893 ? 237 LEU A CD2 1 
ATOM   1934 N N   . HIS A 1 238 ? -43.39845  -24.64121 -115.49199 1.000 22.43804 ? 238 HIS A N   1 
ATOM   1935 C CA  . HIS A 1 238 ? -43.43652  -24.33418 -114.06402 1.000 23.05684 ? 238 HIS A CA  1 
ATOM   1936 C C   . HIS A 1 238 ? -43.31592  -22.82408 -113.89166 1.000 19.50724 ? 238 HIS A C   1 
ATOM   1937 O O   . HIS A 1 238 ? -42.52073  -22.17777 -114.58518 1.000 21.72173 ? 238 HIS A O   1 
ATOM   1938 C CB  . HIS A 1 238 ? -42.31074  -25.03139 -113.28017 1.000 16.93265 ? 238 HIS A CB  1 
ATOM   1939 C CG  . HIS A 1 238 ? -42.49290  -26.50854 -113.10413 1.000 21.35007 ? 238 HIS A CG  1 
ATOM   1940 N ND1 . HIS A 1 238 ? -41.67423  -27.26028 -112.29010 1.000 23.32391 ? 238 HIS A ND1 1 
ATOM   1941 C CD2 . HIS A 1 238 ? -43.37626  -27.37933 -113.64955 1.000 20.36599 ? 238 HIS A CD2 1 
ATOM   1942 C CE1 . HIS A 1 238 ? -42.04406  -28.52947 -112.33948 1.000 22.29610 ? 238 HIS A CE1 1 
ATOM   1943 N NE2 . HIS A 1 238 ? -43.07939  -28.62800 -113.15324 1.000 22.70983 ? 238 HIS A NE2 1 
ATOM   1944 N N   . ILE A 1 239 ? -44.11906  -22.26512 -112.99211 1.000 18.63998 ? 239 ILE A N   1 
ATOM   1945 C CA  . ILE A 1 239 ? -43.91410  -20.90729 -112.50217 1.000 21.70702 ? 239 ILE A CA  1 
ATOM   1946 C C   . ILE A 1 239 ? -43.04695  -21.06140 -111.26402 1.000 21.91576 ? 239 ILE A C   1 
ATOM   1947 O O   . ILE A 1 239 ? -43.48590  -21.65071 -110.27784 1.000 19.92895 ? 239 ILE A O   1 
ATOM   1948 C CB  . ILE A 1 239 ? -45.23341  -20.20273 -112.16044 1.000 24.69588 ? 239 ILE A CB  1 
ATOM   1949 C CG1 . ILE A 1 239 ? -46.28443  -20.37416 -113.26469 1.000 22.33960 ? 239 ILE A CG1 1 
ATOM   1950 C CG2 . ILE A 1 239 ? -44.95510  -18.73868 -111.76376 1.000 20.79947 ? 239 ILE A CG2 1 
ATOM   1951 C CD1 . ILE A 1 239 ? -45.96610  -19.69552 -114.57875 1.000 19.15962 ? 239 ILE A CD1 1 
ATOM   1952 N N   . THR A 1 240 ? -41.81963  -20.54310 -111.30663 1.000 21.26498 ? 240 THR A N   1 
ATOM   1953 C CA  . THR A 1 240 ? -40.82566  -20.99277 -110.34112 1.000 23.70734 ? 240 THR A CA  1 
ATOM   1954 C C   . THR A 1 240 ? -40.48309  -19.97986 -109.25255 1.000 21.47363 ? 240 THR A C   1 
ATOM   1955 O O   . THR A 1 240 ? -39.98819  -20.38566 -108.20222 1.000 22.94164 ? 240 THR A O   1 
ATOM   1956 C CB  . THR A 1 240 ? -39.56039  -21.44227 -111.08623 1.000 19.47734 ? 240 THR A CB  1 
ATOM   1957 O OG1 . THR A 1 240 ? -38.92268  -20.33025 -111.72906 1.000 25.63376 ? 240 THR A OG1 1 
ATOM   1958 C CG2 . THR A 1 240 ? -39.92610  -22.50434 -112.15047 1.000 14.28955 ? 240 THR A CG2 1 
ATOM   1959 N N   . GLY A 1 241 ? -40.73084  -18.69094 -109.43415 1.000 25.81652 ? 241 GLY A N   1 
ATOM   1960 C CA  . GLY A 1 241 ? -40.30420  -17.75256 -108.42309 1.000 25.81652 ? 241 GLY A CA  1 
ATOM   1961 C C   . GLY A 1 241 ? -41.28801  -16.62682 -108.22627 1.000 25.81652 ? 241 GLY A C   1 
ATOM   1962 O O   . GLY A 1 241 ? -40.89322  -15.47628 -108.03366 1.000 25.81652 ? 241 GLY A O   1 
ATOM   1963 N N   . LEU A 1 242 ? -42.57993  -16.95546 -108.26659 1.000 22.10831 ? 242 LEU A N   1 
ATOM   1964 C CA  . LEU A 1 242 ? -43.64960  -15.95172 -108.31866 1.000 20.27354 ? 242 LEU A CA  1 
ATOM   1965 C C   . LEU A 1 242 ? -43.63353  -15.01733 -107.10969 1.000 19.41982 ? 242 LEU A C   1 
ATOM   1966 O O   . LEU A 1 242 ? -43.60751  -15.46559 -105.95511 1.000 21.16049 ? 242 LEU A O   1 
ATOM   1967 C CB  . LEU A 1 242 ? -45.01728  -16.63894 -108.41554 1.000 19.20023 ? 242 LEU A CB  1 
ATOM   1968 C CG  . LEU A 1 242 ? -46.24290  -15.71044 -108.40464 1.000 23.68204 ? 242 LEU A CG  1 
ATOM   1969 C CD1 . LEU A 1 242 ? -46.22879  -14.83736 -109.65813 1.000 21.34562 ? 242 LEU A CD1 1 
ATOM   1970 C CD2 . LEU A 1 242 ? -47.54241  -16.50339 -108.34408 1.000 15.52220 ? 242 LEU A CD2 1 
ATOM   1971 N N   . ASP A 1 243 ? -43.62167  -13.71495 -107.39804 1.000 20.89572 ? 243 ASP A N   1 
ATOM   1972 C CA  . ASP A 1 243 ? -43.94795  -12.67850 -106.43805 1.000 20.24417 ? 243 ASP A CA  1 
ATOM   1973 C C   . ASP A 1 243 ? -44.43647  -11.46698 -107.21100 1.000 22.76941 ? 243 ASP A C   1 
ATOM   1974 O O   . ASP A 1 243 ? -44.15565  -11.30653 -108.40171 1.000 25.78514 ? 243 ASP A O   1 
ATOM   1975 C CB  . ASP A 1 243 ? -42.77216  -12.31733 -105.52341 1.000 18.54950 ? 243 ASP A CB  1 
ATOM   1976 C CG  . ASP A 1 243 ? -41.41856  -12.34815 -106.23215 1.000 21.46156 ? 243 ASP A CG  1 
ATOM   1977 O OD1 . ASP A 1 243 ? -41.31475  -12.05343 -107.44835 1.000 22.14591 ? 243 ASP A OD1 1 
ATOM   1978 O OD2 . ASP A 1 243 ? -40.43395  -12.67982 -105.54696 1.000 22.78036 ? 243 ASP A OD2 1 
ATOM   1979 N N   . VAL A 1 244 ? -45.20097  -10.62924 -106.52501 1.000 25.65200 ? 244 VAL A N   1 
ATOM   1980 C CA  . VAL A 1 244 ? -45.79829  -9.44493  -107.12093 1.000 23.83437 ? 244 VAL A CA  1 
ATOM   1981 C C   . VAL A 1 244 ? -45.30078  -8.25454  -106.32029 1.000 21.88826 ? 244 VAL A C   1 
ATOM   1982 O O   . VAL A 1 244 ? -45.84003  -7.94213  -105.25041 1.000 24.70030 ? 244 VAL A O   1 
ATOM   1983 C CB  . VAL A 1 244 ? -47.32812  -9.52592  -107.15843 1.000 23.89302 ? 244 VAL A CB  1 
ATOM   1984 C CG1 . VAL A 1 244 ? -47.90218  -8.29736  -107.82858 1.000 24.10523 ? 244 VAL A CG1 1 
ATOM   1985 C CG2 . VAL A 1 244 ? -47.74708  -10.75745 -107.95011 1.000 18.86209 ? 244 VAL A CG2 1 
ATOM   1986 N N   . SER A 1 245 ? -44.24304  -7.62020  -106.82601 1.000 25.92911 ? 245 SER A N   1 
ATOM   1987 C CA  . SER A 1 245 ? -43.63063  -6.46318  -106.18721 1.000 24.21578 ? 245 SER A CA  1 
ATOM   1988 C C   . SER A 1 245 ? -44.59017  -5.28400  -106.11808 1.000 28.53449 ? 245 SER A C   1 
ATOM   1989 O O   . SER A 1 245 ? -45.37358  -5.03825  -107.04028 1.000 29.65371 ? 245 SER A O   1 
ATOM   1990 C CB  . SER A 1 245 ? -42.37871  -6.04763  -106.96234 1.000 20.89751 ? 245 SER A CB  1 
ATOM   1991 O OG  . SER A 1 245 ? -41.84644  -4.82232  -106.47534 1.000 26.75974 ? 245 SER A OG  1 
ATOM   1992 N N   . MET A 1 246 ? -44.49959  -4.53236  -105.03106 1.000 29.70337 ? 246 MET A N   1 
ATOM   1993 C CA  . MET A 1 246 ? -45.26029  -3.30141  -104.87819 1.000 27.18138 ? 246 MET A CA  1 
ATOM   1994 C C   . MET A 1 246 ? -44.65209  -2.13087  -105.64847 1.000 26.87717 ? 246 MET A C   1 
ATOM   1995 O O   . MET A 1 246 ? -45.27189  -1.06967  -105.72549 1.000 33.21878 ? 246 MET A O   1 
ATOM   1996 C CB  . MET A 1 246 ? -45.35672  -2.95501  -103.38840 1.000 27.19014 ? 246 MET A CB  1 
ATOM   1997 C CG  . MET A 1 246 ? -46.28020  -3.83112  -102.57564 1.000 32.04759 ? 246 MET A CG  1 
ATOM   1998 S SD  . MET A 1 246 ? -47.87689  -4.08553  -103.36984 1.000 30.34869 ? 246 MET A SD  1 
ATOM   1999 C CE  . MET A 1 246 ? -48.84043  -4.70487  -102.00270 1.000 28.03090 ? 246 MET A CE  1 
ATOM   2000 N N   . PHE A 1 247 ? -43.45995  -2.29515  -106.21650 1.000 23.58628 ? 247 PHE A N   1 
ATOM   2001 C CA  . PHE A 1 247 ? -42.73875  -1.22891  -106.89696 1.000 28.44137 ? 247 PHE A CA  1 
ATOM   2002 C C   . PHE A 1 247 ? -42.46582  -1.67040  -108.32357 1.000 33.16975 ? 247 PHE A C   1 
ATOM   2003 O O   . PHE A 1 247 ? -42.02218  -2.80466  -108.53959 1.000 30.72100 ? 247 PHE A O   1 
ATOM   2004 C CB  . PHE A 1 247 ? -41.39141  -0.91362  -106.21571 1.000 28.95243 ? 247 PHE A CB  1 
ATOM   2005 C CG  . PHE A 1 247 ? -41.49066  -0.56798  -104.75372 1.000 31.73017 ? 247 PHE A CG  1 
ATOM   2006 C CD1 . PHE A 1 247 ? -41.88320  0.69865   -104.34867 1.000 33.27540 ? 247 PHE A CD1 1 
ATOM   2007 C CD2 . PHE A 1 247 ? -41.15645  -1.50201  -103.78106 1.000 28.77495 ? 247 PHE A CD2 1 
ATOM   2008 C CE1 . PHE A 1 247 ? -41.96469  1.02392   -102.99612 1.000 31.44756 ? 247 PHE A CE1 1 
ATOM   2009 C CE2 . PHE A 1 247 ? -41.23812  -1.18513  -102.42399 1.000 30.51536 ? 247 PHE A CE2 1 
ATOM   2010 C CZ  . PHE A 1 247 ? -41.63757  0.07841   -102.03285 1.000 29.93313 ? 247 PHE A CZ  1 
ATOM   2011 N N   . GLU A 1 248 ? -42.71753  -0.77878  -109.28769 1.000 28.95147 ? 248 GLU A N   1 
ATOM   2012 C CA  . GLU A 1 248 ? -42.26398  -0.99609  -110.65685 1.000 26.85658 ? 248 GLU A CA  1 
ATOM   2013 C C   . GLU A 1 248 ? -40.74420  -0.88094  -110.72383 1.000 31.24868 ? 248 GLU A C   1 
ATOM   2014 O O   . GLU A 1 248 ? -40.08321  -0.46567  -109.76800 1.000 30.37776 ? 248 GLU A O   1 
ATOM   2015 C CB  . GLU A 1 248 ? -42.90190  0.01028   -111.61655 1.000 29.12991 ? 248 GLU A CB  1 
ATOM   2016 C CG  . GLU A 1 248 ? -44.41252  -0.01621  -111.61708 1.000 23.30258 ? 248 GLU A CG  1 
ATOM   2017 C CD  . GLU A 1 248 ? -44.97473  -1.35437  -112.07917 1.000 27.36215 ? 248 GLU A CD  1 
ATOM   2018 O OE1 . GLU A 1 248 ? -44.34650  -2.00532  -112.94268 1.000 26.17076 ? 248 GLU A OE1 1 
ATOM   2019 O OE2 . GLU A 1 248 ? -46.04938  -1.75461  -111.57920 1.000 27.50943 ? 248 GLU A OE2 1 
ATOM   2020 N N   . PHE A 1 249 ? -40.19163  -1.25024  -111.88149 1.000 30.04649 ? 249 PHE A N   1 
ATOM   2021 C CA  . PHE A 1 249 ? -38.74255  -1.23881  -112.04358 1.000 33.94506 ? 249 PHE A CA  1 
ATOM   2022 C C   . PHE A 1 249 ? -38.15537  0.15191   -111.82950 1.000 36.97754 ? 249 PHE A C   1 
ATOM   2023 O O   . PHE A 1 249 ? -37.03578  0.28407   -111.31256 1.000 34.75008 ? 249 PHE A O   1 
ATOM   2024 C CB  . PHE A 1 249 ? -38.37457  -1.76315  -113.43090 1.000 32.67430 ? 249 PHE A CB  1 
ATOM   2025 C CG  . PHE A 1 249 ? -36.90059  -1.72817  -113.71940 1.000 36.47599 ? 249 PHE A CG  1 
ATOM   2026 C CD1 . PHE A 1 249 ? -36.06140  -2.71480  -113.21930 1.000 37.11776 ? 249 PHE A CD1 1 
ATOM   2027 C CD2 . PHE A 1 249 ? -36.35141  -0.70071  -114.48627 1.000 36.82135 ? 249 PHE A CD2 1 
ATOM   2028 C CE1 . PHE A 1 249 ? -34.69708  -2.68742  -113.48304 1.000 42.63652 ? 249 PHE A CE1 1 
ATOM   2029 C CE2 . PHE A 1 249 ? -34.99148  -0.66204  -114.74813 1.000 35.42764 ? 249 PHE A CE2 1 
ATOM   2030 C CZ  . PHE A 1 249 ? -34.16138  -1.66025  -114.24470 1.000 40.73102 ? 249 PHE A CZ  1 
ATOM   2031 N N   . HIS A 1 250 ? -38.89485  1.19288   -112.21494 1.000 32.32762 ? 250 HIS A N   1 
ATOM   2032 C CA  . HIS A 1 250 ? -38.44399  2.57951   -112.14411 1.000 32.49313 ? 250 HIS A CA  1 
ATOM   2033 C C   . HIS A 1 250 ? -38.64023  3.19116   -110.76959 1.000 32.27739 ? 250 HIS A C   1 
ATOM   2034 O O   . HIS A 1 250 ? -38.26645  4.34695   -110.56350 1.000 29.90506 ? 250 HIS A O   1 
ATOM   2035 C CB  . HIS A 1 250 ? -39.22716  3.43046   -113.14286 1.000 30.61812 ? 250 HIS A CB  1 
ATOM   2036 C CG  . HIS A 1 250 ? -40.70805  3.39097   -112.90981 1.000 34.79261 ? 250 HIS A CG  1 
ATOM   2037 N ND1 . HIS A 1 250 ? -41.30723  3.99139   -111.82214 1.000 35.30284 ? 250 HIS A ND1 1 
ATOM   2038 C CD2 . HIS A 1 250 ? -41.70814  2.79361   -113.60421 1.000 39.31652 ? 250 HIS A CD2 1 
ATOM   2039 C CE1 . HIS A 1 250 ? -42.61390  3.78541   -111.86637 1.000 33.05389 ? 250 HIS A CE1 1 
ATOM   2040 N NE2 . HIS A 1 250 ? -42.88261  3.05901   -112.93604 1.000 35.66562 ? 250 HIS A NE2 1 
ATOM   2041 N N   . ASP A 1 251 ? -39.26911  2.47059   -109.85760 1.000 32.56574 ? 251 ASP A N   1 
ATOM   2042 C CA  . ASP A 1 251 ? -39.68144  3.01001   -108.57355 1.000 31.93457 ? 251 ASP A CA  1 
ATOM   2043 C C   . ASP A 1 251 ? -38.65106  2.54590   -107.55146 1.000 37.58652 ? 251 ASP A C   1 
ATOM   2044 O O   . ASP A 1 251 ? -38.77808  1.47203   -106.96500 1.000 32.80082 ? 251 ASP A O   1 
ATOM   2045 C CB  . ASP A 1 251 ? -41.08823  2.53675   -108.24572 1.000 34.64919 ? 251 ASP A CB  1 
ATOM   2046 C CG  . ASP A 1 251 ? -41.66976  3.23711   -107.05394 1.000 35.40446 ? 251 ASP A CG  1 
ATOM   2047 O OD1 . ASP A 1 251 ? -40.90507  3.93579   -106.36735 1.000 33.82396 ? 251 ASP A OD1 1 
ATOM   2048 O OD2 . ASP A 1 251 ? -42.88777  3.09564   -106.80605 1.000 35.68564 ? 251 ASP A OD2 1 
ATOM   2049 N N   . ARG A 1 252 ? -37.60931  3.35610   -107.35765 1.000 30.33546 ? 252 ARG A N   1 
ATOM   2050 C CA  . ARG A 1 252 ? -36.51541  3.03022   -106.44315 1.000 32.63027 ? 252 ARG A CA  1 
ATOM   2051 C C   . ARG A 1 252 ? -36.67493  3.72494   -105.09223 1.000 36.50764 ? 252 ARG A C   1 
ATOM   2052 O O   . ARG A 1 252 ? -35.68983  4.13632   -104.47362 1.000 40.56652 ? 252 ARG A O   1 
ATOM   2053 C CB  . ARG A 1 252 ? -35.17301  3.37316   -107.08453 1.000 33.05300 ? 252 ARG A CB  1 
ATOM   2054 C CG  . ARG A 1 252 ? -34.89143  2.59038   -108.37410 1.000 35.76092 ? 252 ARG A CG  1 
ATOM   2055 C CD  . ARG A 1 252 ? -35.03304  1.08282   -108.11504 1.000 35.32669 ? 252 ARG A CD  1 
ATOM   2056 N NE  . ARG A 1 252 ? -34.99104  0.26556   -109.32312 1.000 35.64342 ? 252 ARG A NE  1 
ATOM   2057 C CZ  . ARG A 1 252 ? -33.89723  -0.29023  -109.84153 1.000 43.06605 ? 252 ARG A CZ  1 
ATOM   2058 N NH1 . ARG A 1 252 ? -32.71476  -0.15418  -109.25243 1.000 42.05919 ? 252 ARG A NH1 1 
ATOM   2059 N NH2 . ARG A 1 252 ? -33.99607  -1.00461  -110.95506 1.000 44.72652 ? 252 ARG A NH2 1 
ATOM   2060 N N   . ARG A 1 253 ? -37.91333  3.85682   -104.61012 1.000 29.93173 ? 253 ARG A N   1 
ATOM   2061 C CA  . ARG A 1 253 ? -38.17263  4.54019   -103.34764 1.000 31.44650 ? 253 ARG A CA  1 
ATOM   2062 C C   . ARG A 1 253 ? -37.71794  3.70732   -102.15260 1.000 39.90716 ? 253 ARG A C   1 
ATOM   2063 O O   . ARG A 1 253 ? -37.91736  2.48958   -102.11136 1.000 33.79400 ? 253 ARG A O   1 
ATOM   2064 C CB  . ARG A 1 253 ? -39.65713  4.84467   -103.20844 1.000 32.27469 ? 253 ARG A CB  1 
ATOM   2065 C CG  . ARG A 1 253 ? -40.14248  5.99025   -104.07645 1.000 35.46065 ? 253 ARG A CG  1 
ATOM   2066 C CD  . ARG A 1 253 ? -41.62134  6.24554   -103.82339 1.000 32.26040 ? 253 ARG A CD  1 
ATOM   2067 N NE  . ARG A 1 253 ? -42.44657  5.13762   -104.28880 1.000 32.30692 ? 253 ARG A NE  1 
ATOM   2068 C CZ  . ARG A 1 253 ? -43.75439  5.03315   -104.07211 1.000 31.47889 ? 253 ARG A CZ  1 
ATOM   2069 N NH1 . ARG A 1 253 ? -44.39596  5.97030   -103.39959 1.000 36.98157 ? 253 ARG A NH1 1 
ATOM   2070 N NH2 . ARG A 1 253 ? -44.42699  3.99530   -104.53820 1.000 30.24710 ? 253 ARG A NH2 1 
ATOM   2071 N N   . THR A 1 254 ? -37.14072  4.38247   -101.15225 1.000 43.04855 ? 254 THR A N   1 
ATOM   2072 C CA  . THR A 1 254 ? -36.61938  3.72194   -99.96398  1.000 39.09524 ? 254 THR A CA  1 
ATOM   2073 C C   . THR A 1 254 ? -37.43788  3.95614   -98.69769  1.000 46.01633 ? 254 THR A C   1 
ATOM   2074 O O   . THR A 1 254 ? -37.29281  3.18757   -97.73857  1.000 47.80169 ? 254 THR A O   1 
ATOM   2075 C CB  . THR A 1 254 ? -35.16672  4.16076   -99.70821  1.000 44.74652 ? 254 THR A CB  1 
ATOM   2076 O OG1 . THR A 1 254 ? -35.07967  5.59712   -99.69848  1.000 45.42829 ? 254 THR A OG1 1 
ATOM   2077 C CG2 . THR A 1 254 ? -34.26606  3.61269   -100.78875 1.000 39.41821 ? 254 THR A CG2 1 
ATOM   2078 N N   . ASP A 1 255 ? -38.32325  4.94788   -98.67583  1.000 49.54710 ? 255 ASP A N   1 
ATOM   2079 C CA  . ASP A 1 255 ? -38.86370  5.48198   -97.43797  1.000 43.72011 ? 255 ASP A CA  1 
ATOM   2080 C C   . ASP A 1 255 ? -40.26254  4.98627   -97.09808  1.000 47.34607 ? 255 ASP A C   1 
ATOM   2081 O O   . ASP A 1 255 ? -40.81275  5.38685   -96.06407  1.000 55.11439 ? 255 ASP A O   1 
ATOM   2082 C CB  . ASP A 1 255 ? -38.85745  7.00080   -97.56937  1.000 49.00663 ? 255 ASP A CB  1 
ATOM   2083 C CG  . ASP A 1 255 ? -39.71036  7.46210   -98.72761  1.000 72.61652 ? 255 ASP A CG  1 
ATOM   2084 O OD1 . ASP A 1 255 ? -39.18503  7.53392   -99.87420  1.000 67.73146 ? 255 ASP A OD1 1 
ATOM   2085 O OD2 . ASP A 1 255 ? -40.91680  7.72087   -98.50875  1.000 75.07216 ? 255 ASP A OD2 1 
ATOM   2086 N N   . LEU A 1 256 ? -40.85851  4.14003   -97.92949  1.000 49.61950 ? 256 LEU A N   1 
ATOM   2087 C CA  . LEU A 1 256 ? -42.20049  3.63209   -97.65964  1.000 42.92149 ? 256 LEU A CA  1 
ATOM   2088 C C   . LEU A 1 256 ? -42.14700  2.56181   -96.57978  1.000 47.97214 ? 256 LEU A C   1 
ATOM   2089 O O   . LEU A 1 256 ? -41.55023  1.49977   -96.79195  1.000 50.51931 ? 256 LEU A O   1 
ATOM   2090 C CB  . LEU A 1 256 ? -42.83069  3.05362   -98.92759  1.000 36.67872 ? 256 LEU A CB  1 
ATOM   2091 C CG  . LEU A 1 256 ? -43.85342  3.90995   -99.66506  1.000 37.64370 ? 256 LEU A CG  1 
ATOM   2092 C CD1 . LEU A 1 256 ? -44.49930  3.11867   -100.79205 1.000 39.73873 ? 256 LEU A CD1 1 
ATOM   2093 C CD2 . LEU A 1 256 ? -44.93090  4.42249   -98.71317  1.000 48.88749 ? 256 LEU A CD2 1 
ATOM   2094 N N   . ALA A 1 257 ? -42.77688  2.82560   -95.43118  1.000 44.44741 ? 257 ALA A N   1 
ATOM   2095 C CA  . ALA A 1 257 ? -42.76410  1.87708   -94.32569  1.000 46.61599 ? 257 ALA A CA  1 
ATOM   2096 C C   . ALA A 1 257 ? -43.95389  0.92292   -94.32369  1.000 41.10863 ? 257 ALA A C   1 
ATOM   2097 O O   . ALA A 1 257 ? -43.96545  -0.03788  -93.54322  1.000 40.17573 ? 257 ALA A O   1 
ATOM   2098 C CB  . ALA A 1 257 ? -42.72317  2.63442   -92.99377  1.000 53.44130 ? 257 ALA A CB  1 
ATOM   2099 N N   . ALA A 1 258 ? -44.96569  1.17924   -95.14651  1.000 36.12746 ? 258 ALA A N   1 
ATOM   2100 C CA  . ALA A 1 258 ? -46.09977  0.28138   -95.31646  1.000 35.39336 ? 258 ALA A CA  1 
ATOM   2101 C C   . ALA A 1 258 ? -46.65073  0.50256   -96.71355  1.000 42.10143 ? 258 ALA A C   1 
ATOM   2102 O O   . ALA A 1 258 ? -46.59128  1.62808   -97.22580  1.000 38.32777 ? 258 ALA A O   1 
ATOM   2103 C CB  . ALA A 1 258 ? -47.21122  0.53036   -94.27461  1.000 26.71966 ? 258 ALA A CB  1 
ATOM   2104 N N   . PRO A 1 259 ? -47.20801  -0.53054  -97.34388  1.000 38.11548 ? 259 PRO A N   1 
ATOM   2105 C CA  . PRO A 1 259 ? -47.84000  -0.33666  -98.64828  1.000 35.78849 ? 259 PRO A CA  1 
ATOM   2106 C C   . PRO A 1 259 ? -49.15350  0.40989   -98.49951  1.000 40.08843 ? 259 PRO A C   1 
ATOM   2107 O O   . PRO A 1 259 ? -49.86827  0.26362   -97.50333  1.000 36.32552 ? 259 PRO A O   1 
ATOM   2108 C CB  . PRO A 1 259 ? -48.07607  -1.76658  -99.13910  1.000 36.62238 ? 259 PRO A CB  1 
ATOM   2109 C CG  . PRO A 1 259 ? -48.30925  -2.53878  -97.86752  1.000 36.71281 ? 259 PRO A CG  1 
ATOM   2110 C CD  . PRO A 1 259 ? -47.44493  -1.88582  -96.80875  1.000 33.33501 ? 259 PRO A CD  1 
ATOM   2111 N N   . THR A 1 260 ? -49.46422  1.22096   -99.50733  1.000 34.77748 ? 260 THR A N   1 
ATOM   2112 C CA  . THR A 1 260 ? -50.69982  1.98961   -99.49855  1.000 36.33652 ? 260 THR A CA  1 
ATOM   2113 C C   . THR A 1 260 ? -51.90903  1.06674   -99.63912  1.000 36.73969 ? 260 THR A C   1 
ATOM   2114 O O   . THR A 1 260 ? -51.80554  -0.07038  -100.10267 1.000 38.38681 ? 260 THR A O   1 
ATOM   2115 C CB  . THR A 1 260 ? -50.69241  3.02452   -100.62677 1.000 40.93007 ? 260 THR A CB  1 
ATOM   2116 O OG1 . THR A 1 260 ? -50.74001  2.35544   -101.89885 1.000 44.89470 ? 260 THR A OG1 1 
ATOM   2117 C CG2 . THR A 1 260 ? -49.43984  3.91118   -100.55651 1.000 33.85091 ? 260 THR A CG2 1 
ATOM   2118 N N   . SER A 1 261 ? -53.06990  1.57016   -99.21178  1.000 37.05356 ? 261 SER A N   1 
ATOM   2119 C CA  . SER A 1 261 ? -54.31043  0.84321   -99.44042  1.000 37.50481 ? 261 SER A CA  1 
ATOM   2120 C C   . SER A 1 261 ? -54.49649  0.52339   -100.91219 1.000 35.08663 ? 261 SER A C   1 
ATOM   2121 O O   . SER A 1 261 ? -55.00061  -0.54606  -101.25540 1.000 37.31100 ? 261 SER A O   1 
ATOM   2122 C CB  . SER A 1 261 ? -55.50125  1.65976   -98.92981  1.000 43.75276 ? 261 SER A CB  1 
ATOM   2123 O OG  . SER A 1 261 ? -55.79430  1.31827   -97.58978  1.000 63.07652 ? 261 SER A OG  1 
ATOM   2124 N N   . GLU A 1 262 ? -54.09536  1.44234   -101.79423 1.000 39.06810 ? 262 GLU A N   1 
ATOM   2125 C CA  . GLU A 1 262 ? -54.19531  1.23151   -103.23404 1.000 40.21348 ? 262 GLU A CA  1 
ATOM   2126 C C   . GLU A 1 262 ? -53.27319  0.10866   -103.68690 1.000 38.05660 ? 262 GLU A C   1 
ATOM   2127 O O   . GLU A 1 262 ? -53.69447  -0.75210  -104.47329 1.000 25.72793 ? 262 GLU A O   1 
ATOM   2128 C CB  . GLU A 1 262 ? -53.89284  2.54964   -103.96834 1.000 42.72347 ? 262 GLU A CB  1 
ATOM   2129 C CG  . GLU A 1 262 ? -54.69016  3.75141   -103.37305 1.000 61.65961 ? 262 GLU A CG  1 
ATOM   2130 C CD  . GLU A 1 262 ? -54.11910  4.27356   -102.02739 1.000 70.39095 ? 262 GLU A CD  1 
ATOM   2131 O OE1 . GLU A 1 262 ? -54.91820  4.37630   -101.04652 1.000 69.82527 ? 262 GLU A OE1 1 
ATOM   2132 O OE2 . GLU A 1 262 ? -52.89484  4.58931   -101.94400 1.000 66.91187 ? 262 GLU A OE2 1 
ATOM   2133 N N   . MET A 1 263 ? -52.02422  0.05329   -103.16865 1.000 31.42304 ? 263 MET A N   1 
ATOM   2134 C CA  . MET A 1 263 ? -51.14736  -1.04604  -103.56992 1.000 31.56388 ? 263 MET A CA  1 
ATOM   2135 C C   . MET A 1 263 ? -51.69904  -2.38159  -103.10750 1.000 30.14675 ? 263 MET A C   1 
ATOM   2136 O O   . MET A 1 263 ? -51.69058  -3.35079  -103.86952 1.000 31.88142 ? 263 MET A O   1 
ATOM   2137 C CB  . MET A 1 263 ? -49.70081  -0.92701  -103.06785 1.000 31.65097 ? 263 MET A CB  1 
ATOM   2138 C CG  . MET A 1 263 ? -48.83775  0.20580   -103.60404 1.000 38.45138 ? 263 MET A CG  1 
ATOM   2139 S SD  . MET A 1 263 ? -47.45107  0.52806   -102.46269 1.000 40.88775 ? 263 MET A SD  1 
ATOM   2140 C CE  . MET A 1 263 ? -45.93980  0.19040   -103.33035 1.000 46.87562 ? 263 MET A CE  1 
ATOM   2141 N N   . ILE A 1 264 ? -52.20017  -2.45507  -101.87060 1.000 31.86566 ? 264 ILE A N   1 
ATOM   2142 C CA  . ILE A 1 264 ? -52.75276  -3.70862  -101.36358 1.000 28.25941 ? 264 ILE A CA  1 
ATOM   2143 C C   . ILE A 1 264 ? -53.94895  -4.14533  -102.19492 1.000 28.46674 ? 264 ILE A C   1 
ATOM   2144 O O   . ILE A 1 264 ? -54.10766  -5.33480  -102.51793 1.000 31.96698 ? 264 ILE A O   1 
ATOM   2145 C CB  . ILE A 1 264 ? -53.12142  -3.56957  -99.86998  1.000 28.81420 ? 264 ILE A CB  1 
ATOM   2146 C CG1 . ILE A 1 264 ? -51.85018  -3.56593  -99.02194  1.000 36.13693 ? 264 ILE A CG1 1 
ATOM   2147 C CG2 . ILE A 1 264 ? -54.05900  -4.69661  -99.42199  1.000 21.17523 ? 264 ILE A CG2 1 
ATOM   2148 C CD1 . ILE A 1 264 ? -51.11086  -4.89149  -99.04836  1.000 41.39400 ? 264 ILE A CD1 1 
ATOM   2149 N N   . GLU A 1 265 ? -54.80647  -3.19347  -102.57079 1.000 30.41652 ? 265 GLU A N   1 
ATOM   2150 C CA  . GLU A 1 265 ? -55.99244  -3.53885  -103.34733 1.000 28.75360 ? 265 GLU A CA  1 
ATOM   2151 C C   . GLU A 1 265 ? -55.60940  -3.97036  -104.75385 1.000 25.89820 ? 265 GLU A C   1 
ATOM   2152 O O   . GLU A 1 265 ? -56.08974  -4.99616  -105.25629 1.000 25.41874 ? 265 GLU A O   1 
ATOM   2153 C CB  . GLU A 1 265 ? -56.95294  -2.35041  -103.38255 1.000 28.37266 ? 265 GLU A CB  1 
ATOM   2154 C CG  . GLU A 1 265 ? -58.20773  -2.58240  -104.21910 1.000 33.25354 ? 265 GLU A CG  1 
ATOM   2155 C CD  . GLU A 1 265 ? -59.20331  -1.42619  -104.12236 1.000 44.99975 ? 265 GLU A CD  1 
ATOM   2156 O OE1 . GLU A 1 265 ? -58.88329  -0.30648  -104.58096 1.000 55.69907 ? 265 GLU A OE1 1 
ATOM   2157 O OE2 . GLU A 1 265 ? -60.30948  -1.64351  -103.58734 1.000 52.19245 ? 265 GLU A OE2 1 
ATOM   2158 N N   . ARG A 1 266 ? -54.72236  -3.20890  -105.39912 1.000 25.89657 ? 266 ARG A N   1 
ATOM   2159 C CA  . ARG A 1 266 ? -54.30665  -3.56532  -106.75179 1.000 31.50716 ? 266 ARG A CA  1 
ATOM   2160 C C   . ARG A 1 266 ? -53.52087  -4.87614  -106.77027 1.000 35.52258 ? 266 ARG A C   1 
ATOM   2161 O O   . ARG A 1 266 ? -53.57938  -5.61123  -107.76102 1.000 29.07448 ? 266 ARG A O   1 
ATOM   2162 C CB  . ARG A 1 266 ? -53.50018  -2.41718  -107.36629 1.000 23.46034 ? 266 ARG A CB  1 
ATOM   2163 C CG  . ARG A 1 266 ? -52.86187  -2.70282  -108.72865 1.000 26.44895 ? 266 ARG A CG  1 
ATOM   2164 C CD  . ARG A 1 266 ? -53.84504  -3.23509  -109.80994 1.000 32.60634 ? 266 ARG A CD  1 
ATOM   2165 N NE  . ARG A 1 266 ? -53.11699  -3.60817  -111.03087 1.000 35.60741 ? 266 ARG A NE  1 
ATOM   2166 C CZ  . ARG A 1 266 ? -53.47772  -4.57024  -111.88058 1.000 36.76095 ? 266 ARG A CZ  1 
ATOM   2167 N NH1 . ARG A 1 266 ? -54.58390  -5.28181  -111.66439 1.000 26.20506 ? 266 ARG A NH1 1 
ATOM   2168 N NH2 . ARG A 1 266 ? -52.72171  -4.82977  -112.95255 1.000 29.47069 ? 266 ARG A NH2 1 
ATOM   2169 N N   . GLN A 1 267 ? -52.81132  -5.20600  -105.68107 1.000 29.69188 ? 267 GLN A N   1 
ATOM   2170 C CA  . GLN A 1 267 ? -52.12399  -6.49594  -105.62425 1.000 27.99622 ? 267 GLN A CA  1 
ATOM   2171 C C   . GLN A 1 267 ? -53.11340  -7.64647  -105.52654 1.000 26.53530 ? 267 GLN A C   1 
ATOM   2172 O O   . GLN A 1 267 ? -52.94448  -8.67401  -106.19730 1.000 25.95838 ? 267 GLN A O   1 
ATOM   2173 C CB  . GLN A 1 267 ? -51.14769  -6.53793  -104.44922 1.000 24.91002 ? 267 GLN A CB  1 
ATOM   2174 C CG  . GLN A 1 267 ? -50.42714  -7.88714  -104.29254 1.000 21.69819 ? 267 GLN A CG  1 
ATOM   2175 C CD  . GLN A 1 267 ? -49.52378  -7.89232  -103.09604 1.000 29.86845 ? 267 GLN A CD  1 
ATOM   2176 O OE1 . GLN A 1 267 ? -49.99084  -7.92888  -101.96081 1.000 28.67603 ? 267 GLN A OE1 1 
ATOM   2177 N NE2 . GLN A 1 267 ? -48.21520  -7.81300  -103.33570 1.000 29.72234 ? 267 GLN A NE2 1 
ATOM   2178 N N   . ALA A 1 268 ? -54.15124  -7.49319  -104.69914 1.000 30.25498 ? 268 ALA A N   1 
ATOM   2179 C CA  . ALA A 1 268 ? -55.21499  -8.49291  -104.64294 1.000 27.46085 ? 268 ALA A CA  1 
ATOM   2180 C C   . ALA A 1 268 ? -55.80483  -8.74033  -106.02110 1.000 30.25084 ? 268 ALA A C   1 
ATOM   2181 O O   . ALA A 1 268 ? -55.96355  -9.89210  -106.44879 1.000 33.18867 ? 268 ALA A O   1 
ATOM   2182 C CB  . ALA A 1 268 ? -56.30272  -8.05212  -103.65820 1.000 29.83746 ? 268 ALA A CB  1 
ATOM   2183 N N   . GLU A 1 269 ? -56.12687  -7.66032  -106.74068 1.000 31.76845 ? 269 GLU A N   1 
ATOM   2184 C CA  . GLU A 1 269 ? -56.71542  -7.81604  -108.06591 1.000 30.37277 ? 269 GLU A CA  1 
ATOM   2185 C C   . GLU A 1 269 ? -55.73184  -8.48350  -109.01528 1.000 27.75840 ? 269 GLU A C   1 
ATOM   2186 O O   . GLU A 1 269 ? -56.09739  -9.39418  -109.77226 1.000 30.11660 ? 269 GLU A O   1 
ATOM   2187 C CB  . GLU A 1 269 ? -57.15907  -6.45585  -108.61341 1.000 25.33498 ? 269 GLU A CB  1 
ATOM   2188 C CG  . GLU A 1 269 ? -57.70816  -6.54873  -110.04275 1.000 33.52652 ? 269 GLU A CG  1 
ATOM   2189 C CD  . GLU A 1 269 ? -57.99190  -5.20152  -110.67805 1.000 32.18178 ? 269 GLU A CD  1 
ATOM   2190 O OE1 . GLU A 1 269 ? -57.09703  -4.32186  -110.71615 1.000 31.38624 ? 269 GLU A OE1 1 
ATOM   2191 O OE2 . GLU A 1 269 ? -59.13935  -5.02139  -111.12952 1.000 48.35399 ? 269 GLU A OE2 1 
ATOM   2192 N N   . ARG A 1 270 ? -54.47192  -8.05934  -108.95946 1.000 27.86655 ? 270 ARG A N   1 
ATOM   2193 C CA  . ARG A 1 270 ? -53.42657  -8.62093  -109.81001 1.000 26.59957 ? 270 ARG A CA  1 
ATOM   2194 C C   . ARG A 1 270 ? -53.23310  -10.11672 -109.55220 1.000 24.23979 ? 270 ARG A C   1 
ATOM   2195 O O   . ARG A 1 270 ? -53.11134  -10.91019 -110.49286 1.000 28.41402 ? 270 ARG A O   1 
ATOM   2196 C CB  . ARG A 1 270 ? -52.13555  -7.83989  -109.56515 1.000 28.52270 ? 270 ARG A CB  1 
ATOM   2197 C CG  . ARG A 1 270 ? -50.94542  -8.36451  -110.28283 1.000 33.81987 ? 270 ARG A CG  1 
ATOM   2198 C CD  . ARG A 1 270 ? -50.98790  -8.00815  -111.74348 1.000 29.40442 ? 270 ARG A CD  1 
ATOM   2199 N NE  . ARG A 1 270 ? -49.64114  -8.10364  -112.27643 1.000 26.40339 ? 270 ARG A NE  1 
ATOM   2200 C CZ  . ARG A 1 270 ? -49.33972  -8.33706  -113.54559 1.000 28.69446 ? 270 ARG A CZ  1 
ATOM   2201 N NH1 . ARG A 1 270 ? -50.29673  -8.47862  -114.45583 1.000 25.45368 ? 270 ARG A NH1 1 
ATOM   2202 N NH2 . ARG A 1 270 ? -48.06516  -8.41822  -113.90035 1.000 26.17749 ? 270 ARG A NH2 1 
ATOM   2203 N N   . TYR A 1 271 ? -53.19857  -10.52383 -108.27841 1.000 23.90857 ? 271 TYR A N   1 
ATOM   2204 C CA  . TYR A 1 271 ? -53.05639  -11.94632 -107.96741 1.000 22.00510 ? 271 TYR A CA  1 
ATOM   2205 C C   . TYR A 1 271 ? -54.28988  -12.73616 -108.40127 1.000 25.24668 ? 271 TYR A C   1 
ATOM   2206 O O   . TYR A 1 271 ? -54.17784  -13.87543 -108.87707 1.000 22.99798 ? 271 TYR A O   1 
ATOM   2207 C CB  . TYR A 1 271 ? -52.79405  -12.13225 -106.47208 1.000 20.24007 ? 271 TYR A CB  1 
ATOM   2208 C CG  . TYR A 1 271 ? -51.32328  -12.33165 -106.08109 1.000 23.06578 ? 271 TYR A CG  1 
ATOM   2209 C CD1 . TYR A 1 271 ? -50.60992  -13.44925 -106.50682 1.000 19.48752 ? 271 TYR A CD1 1 
ATOM   2210 C CD2 . TYR A 1 271 ? -50.66479  -11.41878 -105.25165 1.000 23.31906 ? 271 TYR A CD2 1 
ATOM   2211 C CE1 . TYR A 1 271 ? -49.26956  -13.64221 -106.13381 1.000 25.51753 ? 271 TYR A CE1 1 
ATOM   2212 C CE2 . TYR A 1 271 ? -49.31688  -11.61202 -104.86104 1.000 21.62685 ? 271 TYR A CE2 1 
ATOM   2213 C CZ  . TYR A 1 271 ? -48.63180  -12.72940 -105.30448 1.000 22.87933 ? 271 TYR A CZ  1 
ATOM   2214 O OH  . TYR A 1 271 ? -47.31212  -12.94795 -104.93941 1.000 25.17437 ? 271 TYR A OH  1 
ATOM   2215 N N   . GLY A 1 272 ? -55.47839  -12.15277 -108.24680 1.000 27.25479 ? 272 GLY A N   1 
ATOM   2216 C CA  . GLY A 1 272 ? -56.67392  -12.81566 -108.75292 1.000 26.37908 ? 272 GLY A CA  1 
ATOM   2217 C C   . GLY A 1 272 ? -56.61954  -13.05730 -110.25279 1.000 25.61981 ? 272 GLY A C   1 
ATOM   2218 O O   . GLY A 1 272 ? -56.93991  -14.15011 -110.72690 1.000 22.10406 ? 272 GLY A O   1 
ATOM   2219 N N   . GLN A 1 273 ? -56.19416  -12.04583 -111.01859 1.000 26.09019 ? 273 GLN A N   1 
ATOM   2220 C CA  . GLN A 1 273 ? -56.10268  -12.19714 -112.47131 1.000 24.01651 ? 273 GLN A CA  1 
ATOM   2221 C C   . GLN A 1 273 ? -55.04819  -13.22447 -112.86222 1.000 28.85006 ? 273 GLN A C   1 
ATOM   2222 O O   . GLN A 1 273 ? -55.24224  -14.00699 -113.79945 1.000 30.48896 ? 273 GLN A O   1 
ATOM   2223 C CB  . GLN A 1 273 ? -55.78153  -10.84554 -113.11260 1.000 25.84334 ? 273 GLN A CB  1 
ATOM   2224 C CG  . GLN A 1 273 ? -56.85086  -9.78182  -112.88864 1.000 24.46087 ? 273 GLN A CG  1 
ATOM   2225 C CD  . GLN A 1 273 ? -56.36415  -8.38199  -113.23009 1.000 36.62743 ? 273 GLN A CD  1 
ATOM   2226 O OE1 . GLN A 1 273 ? -55.17760  -8.05991  -113.08068 1.000 32.11981 ? 273 GLN A OE1 1 
ATOM   2227 N NE2 . GLN A 1 273 ? -57.28137  -7.53537  -113.67749 1.000 32.96998 ? 273 GLN A NE2 1 
ATOM   2228 N N   . ILE A 1 274 ? -53.91948  -13.22876 -112.15399 1.000 29.84401 ? 274 ILE A N   1 
ATOM   2229 C CA  . ILE A 1 274 ? -52.81858  -14.12410 -112.49007 1.000 27.11931 ? 274 ILE A CA  1 
ATOM   2230 C C   . ILE A 1 274 ? -53.21024  -15.57849 -112.25499 1.000 25.58968 ? 274 ILE A C   1 
ATOM   2231 O O   . ILE A 1 274 ? -52.92251  -16.45883 -113.07242 1.000 27.79243 ? 274 ILE A O   1 
ATOM   2232 C CB  . ILE A 1 274 ? -51.57420  -13.73872 -111.67746 1.000 27.50709 ? 274 ILE A CB  1 
ATOM   2233 C CG1 . ILE A 1 274 ? -50.94151  -12.49136 -112.26423 1.000 27.58995 ? 274 ILE A CG1 1 
ATOM   2234 C CG2 . ILE A 1 274 ? -50.57359  -14.85590 -111.61225 1.000 31.48293 ? 274 ILE A CG2 1 
ATOM   2235 C CD1 . ILE A 1 274 ? -50.07591  -11.83362 -111.24666 1.000 29.60173 ? 274 ILE A CD1 1 
ATOM   2236 N N   . PHE A 1 275 ? -53.87813  -15.86210 -111.13136 1.000 25.51359 ? 275 PHE A N   1 
ATOM   2237 C CA  . PHE A 1 275 ? -54.22874  -17.25220 -110.85896 1.000 25.69119 ? 275 PHE A CA  1 
ATOM   2238 C C   . PHE A 1 275 ? -55.42131  -17.70457 -111.68336 1.000 26.60046 ? 275 PHE A C   1 
ATOM   2239 O O   . PHE A 1 275 ? -55.56249  -18.90384 -111.94724 1.000 28.15709 ? 275 PHE A O   1 
ATOM   2240 C CB  . PHE A 1 275 ? -54.47108  -17.47457 -109.36824 1.000 22.64249 ? 275 PHE A CB  1 
ATOM   2241 C CG  . PHE A 1 275 ? -53.21955  -17.80262 -108.62140 1.000 27.09299 ? 275 PHE A CG  1 
ATOM   2242 C CD1 . PHE A 1 275 ? -52.77409  -19.10892 -108.54413 1.000 28.24306 ? 275 PHE A CD1 1 
ATOM   2243 C CD2 . PHE A 1 275 ? -52.45415  -16.80367 -108.05072 1.000 25.25539 ? 275 PHE A CD2 1 
ATOM   2244 C CE1 . PHE A 1 275 ? -51.59258  -19.41084 -107.87948 1.000 23.58225 ? 275 PHE A CE1 1 
ATOM   2245 C CE2 . PHE A 1 275 ? -51.27794  -17.10874 -107.39562 1.000 26.78581 ? 275 PHE A CE2 1 
ATOM   2246 C CZ  . PHE A 1 275 ? -50.85877  -18.41298 -107.30781 1.000 23.75858 ? 275 PHE A CZ  1 
ATOM   2247 N N   . ALA A 1 276 ? -56.29179  -16.77922 -112.10629 1.000 27.38730 ? 276 ALA A N   1 
ATOM   2248 C CA  . ALA A 1 276 ? -57.33125  -17.16050 -113.05495 1.000 28.37247 ? 276 ALA A CA  1 
ATOM   2249 C C   . ALA A 1 276 ? -56.69907  -17.59470 -114.35827 1.000 25.79357 ? 276 ALA A C   1 
ATOM   2250 O O   . ALA A 1 276 ? -57.05040  -18.63722 -114.91632 1.000 27.05207 ? 276 ALA A O   1 
ATOM   2251 C CB  . ALA A 1 276 ? -58.31147  -16.01332 -113.29285 1.000 23.23979 ? 276 ALA A CB  1 
ATOM   2252 N N   . LEU A 1 277 ? -55.71731  -16.81759 -114.83332 1.000 25.25622 ? 277 LEU A N   1 
ATOM   2253 C CA  . LEU A 1 277 ? -54.98863  -17.16530 -116.04727 1.000 28.04656 ? 277 LEU A CA  1 
ATOM   2254 C C   . LEU A 1 277 ? -54.25874  -18.49688 -115.90736 1.000 33.10190 ? 277 LEU A C   1 
ATOM   2255 O O   . LEU A 1 277 ? -54.29204  -19.32329 -116.83009 1.000 27.51666 ? 277 LEU A O   1 
ATOM   2256 C CB  . LEU A 1 277 ? -54.00355  -16.05831 -116.40303 1.000 21.72573 ? 277 LEU A CB  1 
ATOM   2257 C CG  . LEU A 1 277 ? -53.45654  -16.16115 -117.82605 1.000 23.84298 ? 277 LEU A CG  1 
ATOM   2258 C CD1 . LEU A 1 277 ? -54.60111  -16.16050 -118.84192 1.000 28.91757 ? 277 LEU A CD1 1 
ATOM   2259 C CD2 . LEU A 1 277 ? -52.47597  -15.01687 -118.10912 1.000 26.18304 ? 277 LEU A CD2 1 
ATOM   2260 N N   . PHE A 1 278 ? -53.58401  -18.72049 -114.77083 1.000 24.88845 ? 278 PHE A N   1 
ATOM   2261 C CA  . PHE A 1 278 ? -52.92507  -20.00609 -114.52957 1.000 28.21957 ? 278 PHE A CA  1 
ATOM   2262 C C   . PHE A 1 278 ? -53.93638  -21.15416 -114.53460 1.000 29.15657 ? 278 PHE A C   1 
ATOM   2263 O O   . PHE A 1 278 ? -53.70816  -22.19628 -115.15823 1.000 28.13250 ? 278 PHE A O   1 
ATOM   2264 C CB  . PHE A 1 278 ? -52.17026  -19.98379 -113.18882 1.000 25.28099 ? 278 PHE A CB  1 
ATOM   2265 C CG  . PHE A 1 278 ? -50.95913  -19.07810 -113.16388 1.000 26.46076 ? 278 PHE A CG  1 
ATOM   2266 C CD1 . PHE A 1 278 ? -50.38681  -18.60472 -114.33840 1.000 24.20550 ? 278 PHE A CD1 1 
ATOM   2267 C CD2 . PHE A 1 278 ? -50.38367  -18.71057 -111.94562 1.000 28.52600 ? 278 PHE A CD2 1 
ATOM   2268 C CE1 . PHE A 1 278 ? -49.26981  -17.77350 -114.30171 1.000 23.28484 ? 278 PHE A CE1 1 
ATOM   2269 C CE2 . PHE A 1 278 ? -49.26531  -17.88025 -111.89692 1.000 24.31764 ? 278 PHE A CE2 1 
ATOM   2270 C CZ  . PHE A 1 278 ? -48.70833  -17.40938 -113.07729 1.000 31.11780 ? 278 PHE A CZ  1 
ATOM   2271 N N   . LYS A 1 279 ? -55.04299  -20.99942 -113.79830 1.000 28.57002 ? 279 LYS A N   1 
ATOM   2272 C CA  . LYS A 1 279 ? -56.03203  -22.07026 -113.73122 1.000 30.06306 ? 279 LYS A CA  1 
ATOM   2273 C C   . LYS A 1 279 ? -56.55462  -22.38609 -115.12526 1.000 33.85153 ? 279 LYS A C   1 
ATOM   2274 O O   . LYS A 1 279 ? -56.69518  -23.55528 -115.49580 1.000 35.33056 ? 279 LYS A O   1 
ATOM   2275 C CB  . LYS A 1 279 ? -57.16295  -21.67693 -112.77998 1.000 31.51653 ? 279 LYS A CB  1 
ATOM   2276 C CG  . LYS A 1 279 ? -58.24889  -22.73516 -112.55600 1.000 43.81277 ? 279 LYS A CG  1 
ATOM   2277 C CD  . LYS A 1 279 ? -59.17011  -22.36348 -111.36252 1.000 39.85094 ? 279 LYS A CD  1 
ATOM   2278 C CE  . LYS A 1 279 ? -59.79709  -23.60112 -110.68109 1.000 46.22759 ? 279 LYS A CE  1 
ATOM   2279 N NZ  . LYS A 1 279 ? -59.28740  -23.87640 -109.28105 1.000 51.25464 ? 279 LYS A NZ  1 
ATOM   2280 N N   . GLU A 1 280 ? -56.75985  -21.34789 -115.93755 1.000 34.10453 ? 280 GLU A N   1 
ATOM   2281 C CA  . GLU A 1 280 ? -57.18202  -21.52745 -117.32166 1.000 34.82611 ? 280 GLU A CA  1 
ATOM   2282 C C   . GLU A 1 280 ? -56.17900  -22.36197 -118.11046 1.000 33.87294 ? 280 GLU A C   1 
ATOM   2283 O O   . GLU A 1 280 ? -56.56978  -23.14399 -118.98073 1.000 38.97034 ? 280 GLU A O   1 
ATOM   2284 C CB  . GLU A 1 280 ? -57.38181  -20.15560 -117.97291 1.000 35.52427 ? 280 GLU A CB  1 
ATOM   2285 C CG  . GLU A 1 280 ? -57.87980  -20.17310 -119.39834 1.000 35.45265 ? 280 GLU A CG  1 
ATOM   2286 C CD  . GLU A 1 280 ? -58.08184  -18.76749 -119.96639 1.000 36.04278 ? 280 GLU A CD  1 
ATOM   2287 O OE1 . GLU A 1 280 ? -58.20251  -17.80041 -119.18233 1.000 35.00906 ? 280 GLU A OE1 1 
ATOM   2288 O OE2 . GLU A 1 280 ? -58.10311  -18.62557 -121.20617 1.000 39.66635 ? 280 GLU A OE2 1 
ATOM   2289 N N   . TYR A 1 281 ? -54.87987  -22.21559 -117.83204 1.000 36.40395 ? 281 TYR A N   1 
ATOM   2290 C CA  . TYR A 1 281 ? -53.86453  -23.00005 -118.53076 1.000 33.15176 ? 281 TYR A CA  1 
ATOM   2291 C C   . TYR A 1 281 ? -53.37109  -24.18432 -117.70798 1.000 29.81256 ? 281 TYR A C   1 
ATOM   2292 O O   . TYR A 1 281 ? -52.23036  -24.63414 -117.88983 1.000 29.87406 ? 281 TYR A O   1 
ATOM   2293 C CB  . TYR A 1 281 ? -52.70063  -22.11223 -118.96799 1.000 32.79439 ? 281 TYR A CB  1 
ATOM   2294 C CG  . TYR A 1 281 ? -53.11216  -21.26909 -120.14688 1.000 33.43767 ? 281 TYR A CG  1 
ATOM   2295 C CD1 . TYR A 1 281 ? -52.99149  -21.75030 -121.45037 1.000 26.83786 ? 281 TYR A CD1 1 
ATOM   2296 C CD2 . TYR A 1 281 ? -53.69599  -20.01744 -119.95164 1.000 32.07351 ? 281 TYR A CD2 1 
ATOM   2297 C CE1 . TYR A 1 281 ? -53.40864  -20.98627 -122.53358 1.000 31.52267 ? 281 TYR A CE1 1 
ATOM   2298 C CE2 . TYR A 1 281 ? -54.11646  -19.24902 -121.01786 1.000 33.69318 ? 281 TYR A CE2 1 
ATOM   2299 C CZ  . TYR A 1 281 ? -53.97742  -19.73447 -122.30776 1.000 36.38849 ? 281 TYR A CZ  1 
ATOM   2300 O OH  . TYR A 1 281 ? -54.39861  -18.95360 -123.36298 1.000 34.98366 ? 281 TYR A OH  1 
ATOM   2301 N N   . ARG A 1 282 ? -54.24173  -24.72934 -116.84288 1.000 36.44895 ? 282 ARG A N   1 
ATOM   2302 C CA  . ARG A 1 282 ? -53.86805  -25.84665 -115.98065 1.000 32.33666 ? 282 ARG A CA  1 
ATOM   2303 C C   . ARG A 1 282 ? -53.33217  -27.03732 -116.77198 1.000 37.11826 ? 282 ARG A C   1 
ATOM   2304 O O   . ARG A 1 282 ? -52.58734  -27.85361 -116.22465 1.000 33.70933 ? 282 ARG A O   1 
ATOM   2305 C CB  . ARG A 1 282 ? -55.06342  -26.27799 -115.12472 1.000 32.71171 ? 282 ARG A CB  1 
ATOM   2306 C CG  . ARG A 1 282 ? -56.29913  -26.68762 -115.92415 1.000 37.12867 ? 282 ARG A CG  1 
ATOM   2307 C CD  . ARG A 1 282 ? -57.53823  -26.84228 -115.04310 1.000 33.83105 ? 282 ARG A CD  1 
ATOM   2308 N NE  . ARG A 1 282 ? -57.53240  -28.05993 -114.23051 1.000 39.72337 ? 282 ARG A NE  1 
ATOM   2309 C CZ  . ARG A 1 282 ? -57.79294  -29.28119 -114.70561 1.000 47.82680 ? 282 ARG A CZ  1 
ATOM   2310 N NH1 . ARG A 1 282 ? -58.07083  -29.46025 -115.99644 1.000 40.57193 ? 282 ARG A NH1 1 
ATOM   2311 N NH2 . ARG A 1 282 ? -57.77281  -30.33180 -113.89479 1.000 44.65113 ? 282 ARG A NH2 1 
ATOM   2312 N N   . ASP A 1 283 ? -53.68991  -27.16070 -118.05370 1.000 36.65652 ? 283 ASP A N   1 
ATOM   2313 C CA  . ASP A 1 283 ? -53.22359  -28.31180 -118.81759 1.000 33.76768 ? 283 ASP A CA  1 
ATOM   2314 C C   . ASP A 1 283 ? -51.73259  -28.23573 -119.12554 1.000 37.50722 ? 283 ASP A C   1 
ATOM   2315 O O   . ASP A 1 283 ? -51.12168  -29.26559 -119.43548 1.000 32.54609 ? 283 ASP A O   1 
ATOM   2316 C CB  . ASP A 1 283 ? -54.02017  -28.45683 -120.12087 1.000 40.73652 ? 283 ASP A CB  1 
ATOM   2317 C CG  . ASP A 1 283 ? -55.47406  -28.89312 -119.88509 1.000 50.14652 ? 283 ASP A CG  1 
ATOM   2318 O OD1 . ASP A 1 283 ? -55.73472  -29.71070 -118.96969 1.000 44.64353 ? 283 ASP A OD1 1 
ATOM   2319 O OD2 . ASP A 1 283 ? -56.36593  -28.40752 -120.61280 1.000 52.79977 ? 283 ASP A OD2 1 
ATOM   2320 N N   . VAL A 1 284 ? -51.11762  -27.05891 -119.03528 1.000 38.78336 ? 284 VAL A N   1 
ATOM   2321 C CA  . VAL A 1 284 ? -49.70750  -26.97569 -119.39393 1.000 31.93920 ? 284 VAL A CA  1 
ATOM   2322 C C   . VAL A 1 284 ? -48.85543  -26.47987 -118.22684 1.000 34.29186 ? 284 VAL A C   1 
ATOM   2323 O O   . VAL A 1 284 ? -47.65110  -26.76887 -118.14341 1.000 34.18890 ? 284 VAL A O   1 
ATOM   2324 C CB  . VAL A 1 284 ? -49.52541  -26.11096 -120.65042 1.000 32.66871 ? 284 VAL A CB  1 
ATOM   2325 C CG1 . VAL A 1 284 ? -50.08309  -24.71927 -120.43684 1.000 29.11319 ? 284 VAL A CG1 1 
ATOM   2326 C CG2 . VAL A 1 284 ? -48.05223  -26.06274 -120.98917 1.000 39.09920 ? 284 VAL A CG2 1 
ATOM   2327 N N   . ILE A 1 285 ? -49.46320  -25.75463 -117.29579 1.000 31.98673 ? 285 ILE A N   1 
ATOM   2328 C CA  . ILE A 1 285 ? -48.77529  -25.37660 -116.06734 1.000 29.41349 ? 285 ILE A CA  1 
ATOM   2329 C C   . ILE A 1 285 ? -48.99594  -26.47329 -115.02927 1.000 26.91171 ? 285 ILE A C   1 
ATOM   2330 O O   . ILE A 1 285 ? -50.13981  -26.85731 -114.74762 1.000 30.50808 ? 285 ILE A O   1 
ATOM   2331 C CB  . ILE A 1 285 ? -49.25686  -24.00895 -115.55315 1.000 27.85885 ? 285 ILE A CB  1 
ATOM   2332 C CG1 . ILE A 1 285 ? -48.97635  -22.92278 -116.60464 1.000 25.17092 ? 285 ILE A CG1 1 
ATOM   2333 C CG2 . ILE A 1 285 ? -48.62601  -23.68452 -114.20886 1.000 20.01275 ? 285 ILE A CG2 1 
ATOM   2334 C CD1 . ILE A 1 285 ? -49.55066  -21.58446 -116.24831 1.000 19.19848 ? 285 ILE A CD1 1 
ATOM   2335 N N   . GLN A 1 286 ? -47.89844  -26.98718 -114.45967 1.000 32.47645 ? 286 GLN A N   1 
ATOM   2336 C CA  . GLN A 1 286 ? -47.95866  -28.07826 -113.49028 1.000 29.39144 ? 286 GLN A CA  1 
ATOM   2337 C C   . GLN A 1 286 ? -47.48005  -27.69799 -112.09970 1.000 24.33632 ? 286 GLN A C   1 
ATOM   2338 O O   . GLN A 1 286 ? -47.54811  -28.53232 -111.19364 1.000 26.58226 ? 286 GLN A O   1 
ATOM   2339 C CB  . GLN A 1 286 ? -47.15130  -29.28268 -113.99147 1.000 22.38287 ? 286 GLN A CB  1 
ATOM   2340 C CG  . GLN A 1 286 ? -47.63397  -29.81801 -115.34665 1.000 38.40248 ? 286 GLN A CG  1 
ATOM   2341 C CD  . GLN A 1 286 ? -49.15689  -30.04146 -115.41223 1.000 48.39652 ? 286 GLN A CD  1 
ATOM   2342 O OE1 . GLN A 1 286 ? -49.81007  -30.40652 -114.42291 1.000 45.41652 ? 286 GLN A OE1 1 
ATOM   2343 N NE2 . GLN A 1 286 ? -49.72369  -29.80693 -116.59353 1.000 42.07631 ? 286 GLN A NE2 1 
ATOM   2344 N N   . SER A 1 287 ? -47.02378  -26.46583 -111.89235 1.000 18.30157 ? 287 SER A N   1 
ATOM   2345 C CA  . SER A 1 287 ? -46.52549  -26.08840 -110.58062 1.000 20.75066 ? 287 SER A CA  1 
ATOM   2346 C C   . SER A 1 287 ? -46.34235  -24.58543 -110.54100 1.000 21.63545 ? 287 SER A C   1 
ATOM   2347 O O   . SER A 1 287 ? -45.83723  -23.99093 -111.50197 1.000 23.48360 ? 287 SER A O   1 
ATOM   2348 C CB  . SER A 1 287 ? -45.19483  -26.77926 -110.26849 1.000 22.14076 ? 287 SER A CB  1 
ATOM   2349 O OG  . SER A 1 287 ? -44.61923  -26.21434 -109.11357 1.000 21.32971 ? 287 SER A OG  1 
ATOM   2350 N N   . VAL A 1 288 ? -46.75016  -23.98624 -109.42745 1.000 20.41486 ? 288 VAL A N   1 
ATOM   2351 C CA  . VAL A 1 288 ? -46.61750  -22.55301 -109.19005 1.000 22.34659 ? 288 VAL A CA  1 
ATOM   2352 C C   . VAL A 1 288 ? -45.88640  -22.36735 -107.86667 1.000 25.15475 ? 288 VAL A C   1 
ATOM   2353 O O   . VAL A 1 288 ? -46.46827  -22.57838 -106.79879 1.000 22.35797 ? 288 VAL A O   1 
ATOM   2354 C CB  . VAL A 1 288 ? -47.97969  -21.84513 -109.17192 1.000 18.70227 ? 288 VAL A CB  1 
ATOM   2355 C CG1 . VAL A 1 288 ? -47.77981  -20.36127 -109.08877 1.000 23.49287 ? 288 VAL A CG1 1 
ATOM   2356 C CG2 . VAL A 1 288 ? -48.75163  -22.16546 -110.47006 1.000 20.09906 ? 288 VAL A CG2 1 
ATOM   2357 N N   . THR A 1 289 ? -44.61347  -21.99230 -107.92859 1.000 22.67468 ? 289 THR A N   1 
ATOM   2358 C CA  . THR A 1 289 ? -43.81719  -21.76135 -106.73202 1.000 17.85657 ? 289 THR A CA  1 
ATOM   2359 C C   . THR A 1 289 ? -43.66053  -20.26292 -106.51505 1.000 18.82976 ? 289 THR A C   1 
ATOM   2360 O O   . THR A 1 289 ? -43.32593  -19.52771 -107.45272 1.000 22.08633 ? 289 THR A O   1 
ATOM   2361 C CB  . THR A 1 289 ? -42.44735  -22.43395 -106.84359 1.000 24.20626 ? 289 THR A CB  1 
ATOM   2362 O OG1 . THR A 1 289 ? -42.61316  -23.85780 -106.93404 1.000 20.69866 ? 289 THR A OG1 1 
ATOM   2363 C CG2 . THR A 1 289 ? -41.59451  -22.10487 -105.62919 1.000 17.64648 ? 289 THR A CG2 1 
ATOM   2364 N N   . PHE A 1 290 ? -43.95822  -19.80943 -105.29425 1.000 20.23473 ? 290 PHE A N   1 
ATOM   2365 C CA  . PHE A 1 290 ? -43.63312  -18.45843 -104.84858 1.000 19.87353 ? 290 PHE A CA  1 
ATOM   2366 C C   . PHE A 1 290 ? -42.19148  -18.41535 -104.36150 1.000 22.91266 ? 290 PHE A C   1 
ATOM   2367 O O   . PHE A 1 290 ? -41.69215  -19.37934 -103.77408 1.000 26.95290 ? 290 PHE A O   1 
ATOM   2368 C CB  . PHE A 1 290 ? -44.54644  -18.00192 -103.69876 1.000 21.70028 ? 290 PHE A CB  1 
ATOM   2369 C CG  . PHE A 1 290 ? -46.02584  -17.98785 -104.02721 1.000 22.83306 ? 290 PHE A CG  1 
ATOM   2370 C CD1 . PHE A 1 290 ? -46.77593  -19.15532 -103.99895 1.000 28.69866 ? 290 PHE A CD1 1 
ATOM   2371 C CD2 . PHE A 1 290 ? -46.67103  -16.79639 -104.29896 1.000 21.43466 ? 290 PHE A CD2 1 
ATOM   2372 C CE1 . PHE A 1 290 ? -48.14262  -19.14744 -104.27628 1.000 26.98052 ? 290 PHE A CE1 1 
ATOM   2373 C CE2 . PHE A 1 290 ? -48.03385  -16.77139 -104.56120 1.000 24.74896 ? 290 PHE A CE2 1 
ATOM   2374 C CZ  . PHE A 1 290 ? -48.77030  -17.95556 -104.55994 1.000 26.27492 ? 290 PHE A CZ  1 
ATOM   2375 N N   . TRP A 1 291 ? -41.53324  -17.27608 -104.56371 1.000 17.25568 ? 291 TRP A N   1 
ATOM   2376 C CA  . TRP A 1 291 ? -40.17595  -17.10154 -104.04956 1.000 21.33224 ? 291 TRP A CA  1 
ATOM   2377 C C   . TRP A 1 291 ? -40.22515  -16.59480 -102.60578 1.000 21.64472 ? 291 TRP A C   1 
ATOM   2378 O O   . TRP A 1 291 ? -39.83099  -15.47121 -102.27318 1.000 21.92840 ? 291 TRP A O   1 
ATOM   2379 C CB  . TRP A 1 291 ? -39.38122  -16.17603 -104.96155 1.000 21.21914 ? 291 TRP A CB  1 
ATOM   2380 C CG  . TRP A 1 291 ? -37.93069  -16.54908 -105.04086 1.000 23.32875 ? 291 TRP A CG  1 
ATOM   2381 C CD1 . TRP A 1 291 ? -36.86439  -15.75266 -104.73221 1.000 24.25553 ? 291 TRP A CD1 1 
ATOM   2382 C CD2 . TRP A 1 291 ? -37.38223  -17.81009 -105.45720 1.000 18.82069 ? 291 TRP A CD2 1 
ATOM   2383 N NE1 . TRP A 1 291 ? -35.69149  -16.43105 -104.94280 1.000 18.67804 ? 291 TRP A NE1 1 
ATOM   2384 C CE2 . TRP A 1 291 ? -35.97869  -17.69894 -105.37607 1.000 21.20906 ? 291 TRP A CE2 1 
ATOM   2385 C CE3 . TRP A 1 291 ? -37.94073  -19.01693 -105.90098 1.000 21.68480 ? 291 TRP A CE3 1 
ATOM   2386 C CZ2 . TRP A 1 291 ? -35.12223  -18.75107 -105.70834 1.000 17.85369 ? 291 TRP A CZ2 1 
ATOM   2387 C CZ3 . TRP A 1 291 ? -37.08907  -20.06660 -106.23000 1.000 24.93834 ? 291 TRP A CZ3 1 
ATOM   2388 C CH2 . TRP A 1 291 ? -35.69332  -19.92221 -106.14175 1.000 19.08378 ? 291 TRP A CH2 1 
ATOM   2389 N N   . GLY A 1 292 ? -40.73114  -17.46657 -101.74153 1.000 22.88796 ? 292 GLY A N   1 
ATOM   2390 C CA  . GLY A 1 292 ? -41.05554  -17.15549 -100.36992 1.000 17.66986 ? 292 GLY A CA  1 
ATOM   2391 C C   . GLY A 1 292 ? -42.43451  -17.67316 -100.05586 1.000 21.50497 ? 292 GLY A C   1 
ATOM   2392 O O   . GLY A 1 292 ? -42.99707  -18.47773 -100.79694 1.000 27.84016 ? 292 GLY A O   1 
ATOM   2393 N N   . ILE A 1 293 ? -43.00482  -17.18868 -98.93781  1.000 23.75073 ? 293 ILE A N   1 
ATOM   2394 C CA  . ILE A 1 293 ? -44.41581  -17.49626 -98.68264  1.000 25.41239 ? 293 ILE A CA  1 
ATOM   2395 C C   . ILE A 1 293 ? -45.13899  -16.37238 -97.94201  1.000 27.24402 ? 293 ILE A C   1 
ATOM   2396 O O   . ILE A 1 293 ? -46.34304  -16.16100 -98.14873  1.000 27.68596 ? 293 ILE A O   1 
ATOM   2397 C CB  . ILE A 1 293 ? -44.57701  -18.83499 -97.93875  1.000 22.82728 ? 293 ILE A CB  1 
ATOM   2398 C CG1 . ILE A 1 293 ? -46.07247  -19.17570 -97.81194  1.000 25.29408 ? 293 ILE A CG1 1 
ATOM   2399 C CG2 . ILE A 1 293 ? -43.84281  -18.80103 -96.60696  1.000 26.97235 ? 293 ILE A CG2 1 
ATOM   2400 C CD1 . ILE A 1 293 ? -46.37109  -20.61356 -97.52806  1.000 31.52004 ? 293 ILE A CD1 1 
ATOM   2401 N N   . ALA A 1 294 ? -44.43350  -15.62976 -97.08820  1.000 28.15571 ? 294 ALA A N   1 
ATOM   2402 C CA  . ALA A 1 294 ? -45.05075  -14.52333 -96.37558  1.000 27.13403 ? 294 ALA A CA  1 
ATOM   2403 C C   . ALA A 1 294 ? -44.10149  -13.34663 -96.39863  1.000 25.48526 ? 294 ALA A C   1 
ATOM   2404 O O   . ALA A 1 294 ? -42.89618  -13.51199 -96.59367  1.000 27.08540 ? 294 ALA A O   1 
ATOM   2405 C CB  . ALA A 1 294 ? -45.39972  -14.89343 -94.93016  1.000 32.52233 ? 294 ALA A CB  1 
ATOM   2406 N N   . ASP A 1 295 ? -44.65609  -12.15124 -96.18796  1.000 23.65616 ? 295 ASP A N   1 
ATOM   2407 C CA  . ASP A 1 295 ? -43.87415  -10.93380 -96.39196  1.000 26.99071 ? 295 ASP A CA  1 
ATOM   2408 C C   . ASP A 1 295 ? -42.82734  -10.67767 -95.30484  1.000 32.81045 ? 295 ASP A C   1 
ATOM   2409 O O   . ASP A 1 295 ? -42.12479  -9.65541  -95.37984  1.000 27.47539 ? 295 ASP A O   1 
ATOM   2410 C CB  . ASP A 1 295 ? -44.79818  -9.72094  -96.51020  1.000 24.66947 ? 295 ASP A CB  1 
ATOM   2411 C CG  . ASP A 1 295 ? -45.75553  -9.80719  -97.72830  1.000 30.94116 ? 295 ASP A CG  1 
ATOM   2412 O OD1 . ASP A 1 295 ? -45.51868  -10.59615 -98.67577  1.000 23.80754 ? 295 ASP A OD1 1 
ATOM   2413 O OD2 . ASP A 1 295 ? -46.75137  -9.05884  -97.73713  1.000 25.16368 ? 295 ASP A OD2 1 
ATOM   2414 N N   . ASP A 1 296 ? -42.68941  -11.55126 -94.30429  1.000 27.68483 ? 296 ASP A N   1 
ATOM   2415 C CA  . ASP A 1 296 ? -41.59629  -11.37715 -93.34659  1.000 34.34157 ? 296 ASP A CA  1 
ATOM   2416 C C   . ASP A 1 296 ? -40.25911  -11.86499 -93.89002  1.000 31.97359 ? 296 ASP A C   1 
ATOM   2417 O O   . ASP A 1 296 ? -39.21602  -11.52979 -93.31719  1.000 35.79633 ? 296 ASP A O   1 
ATOM   2418 C CB  . ASP A 1 296 ? -41.91293  -12.07420 -92.01547  1.000 27.48306 ? 296 ASP A CB  1 
ATOM   2419 C CG  . ASP A 1 296 ? -42.32121  -13.51339 -92.18758  1.000 32.12905 ? 296 ASP A CG  1 
ATOM   2420 O OD1 . ASP A 1 296 ? -42.82829  -13.86945 -93.26715  1.000 36.23272 ? 296 ASP A OD1 1 
ATOM   2421 O OD2 . ASP A 1 296 ? -42.16505  -14.29328 -91.22884  1.000 37.35915 ? 296 ASP A OD2 1 
ATOM   2422 N N   . HIS A 1 297 ? -40.25934  -12.61479 -94.99177  1.000 30.73275 ? 297 HIS A N   1 
ATOM   2423 C CA  . HIS A 1 297 ? -39.02564  -12.93831 -95.70139  1.000 28.55968 ? 297 HIS A CA  1 
ATOM   2424 C C   . HIS A 1 297 ? -39.25634  -12.79189 -97.19649  1.000 30.85107 ? 297 HIS A C   1 
ATOM   2425 O O   . HIS A 1 297 ? -40.02137  -13.56133 -97.78259  1.000 23.02019 ? 297 HIS A O   1 
ATOM   2426 C CB  . HIS A 1 297 ? -38.54580  -14.35181 -95.38718  1.000 32.53025 ? 297 HIS A CB  1 
ATOM   2427 C CG  . HIS A 1 297 ? -37.32330  -14.73881 -96.15398  1.000 29.70288 ? 297 HIS A CG  1 
ATOM   2428 N ND1 . HIS A 1 297 ? -36.04980  -14.44143 -95.71403  1.000 30.56440 ? 297 HIS A ND1 1 
ATOM   2429 C CD2 . HIS A 1 297 ? -37.17607  -15.37169 -97.34243  1.000 26.48686 ? 297 HIS A CD2 1 
ATOM   2430 C CE1 . HIS A 1 297 ? -35.17064  -14.88325 -96.59399  1.000 35.20150 ? 297 HIS A CE1 1 
ATOM   2431 N NE2 . HIS A 1 297 ? -35.82740  -15.45412 -97.59031  1.000 35.03179 ? 297 HIS A NE2 1 
ATOM   2432 N N   . THR A 1 298 ? -38.57732  -11.83157 -97.81621  1.000 23.79567 ? 298 THR A N   1 
ATOM   2433 C CA  . THR A 1 298 ? -38.56312  -11.72944 -99.26596  1.000 27.24706 ? 298 THR A CA  1 
ATOM   2434 C C   . THR A 1 298 ? -37.24942  -11.09769 -99.70813  1.000 26.99381 ? 298 THR A C   1 
ATOM   2435 O O   . THR A 1 298 ? -36.79318  -10.11957 -99.11321  1.000 27.90734 ? 298 THR A O   1 
ATOM   2436 C CB  . THR A 1 298 ? -39.76043  -10.92644 -99.79735  1.000 23.70652 ? 298 THR A CB  1 
ATOM   2437 O OG1 . THR A 1 298 ? -39.69843  -10.89505 -101.22763 1.000 23.44680 ? 298 THR A OG1 1 
ATOM   2438 C CG2 . THR A 1 298 ? -39.75963  -9.50919  -99.24830  1.000 27.13029 ? 298 THR A CG2 1 
ATOM   2439 N N   . TRP A 1 299 ? -36.64031  -11.68577 -100.74694 1.000 20.73172 ? 299 TRP A N   1 
ATOM   2440 C CA  . TRP A 1 299 ? -35.44831  -11.10727 -101.37102 1.000 24.75098 ? 299 TRP A CA  1 
ATOM   2441 C C   . TRP A 1 299 ? -35.71674  -9.74429  -101.98255 1.000 25.92873 ? 299 TRP A C   1 
ATOM   2442 O O   . TRP A 1 299 ? -34.76287  -9.01444  -102.27943 1.000 31.36945 ? 299 TRP A O   1 
ATOM   2443 C CB  . TRP A 1 299 ? -34.90544  -12.02936 -102.47104 1.000 22.33763 ? 299 TRP A CB  1 
ATOM   2444 C CG  . TRP A 1 299 ? -35.75388  -12.00728 -103.74052 1.000 24.55996 ? 299 TRP A CG  1 
ATOM   2445 C CD1 . TRP A 1 299 ? -37.08049  -12.32782 -103.85284 1.000 22.78181 ? 299 TRP A CD1 1 
ATOM   2446 C CD2 . TRP A 1 299 ? -35.31572  -11.65453 -105.05985 1.000 23.53222 ? 299 TRP A CD2 1 
ATOM   2447 N NE1 . TRP A 1 299 ? -37.49431  -12.19364 -105.16053 1.000 23.24276 ? 299 TRP A NE1 1 
ATOM   2448 C CE2 . TRP A 1 299 ? -36.43073  -11.77846 -105.91866 1.000 22.77348 ? 299 TRP A CE2 1 
ATOM   2449 C CE3 . TRP A 1 299 ? -34.08743  -11.25014 -105.59870 1.000 22.58814 ? 299 TRP A CE3 1 
ATOM   2450 C CZ2 . TRP A 1 299 ? -36.35611  -11.49842 -107.28491 1.000 24.92659 ? 299 TRP A CZ2 1 
ATOM   2451 C CZ3 . TRP A 1 299 ? -34.01313  -10.97787 -106.95440 1.000 24.08606 ? 299 TRP A CZ3 1 
ATOM   2452 C CH2 . TRP A 1 299 ? -35.13907  -11.09591 -107.78176 1.000 28.85448 ? 299 TRP A CH2 1 
ATOM   2453 N N   . LEU A 1 300 ? -36.98713  -9.39852  -102.21453 1.000 26.36238 ? 300 LEU A N   1 
ATOM   2454 C CA  . LEU A 1 300 ? -37.32619  -8.09009  -102.75812 1.000 25.66210 ? 300 LEU A CA  1 
ATOM   2455 C C   . LEU A 1 300 ? -37.12596  -6.96601  -101.75106 1.000 30.34454 ? 300 LEU A C   1 
ATOM   2456 O O   . LEU A 1 300 ? -37.16117  -5.79449  -102.14663 1.000 30.76106 ? 300 LEU A O   1 
ATOM   2457 C CB  . LEU A 1 300 ? -38.77064  -8.08961  -103.25489 1.000 23.95589 ? 300 LEU A CB  1 
ATOM   2458 C CG  . LEU A 1 300 ? -39.07755  -8.98668  -104.46383 1.000 21.80014 ? 300 LEU A CG  1 
ATOM   2459 C CD1 . LEU A 1 300 ? -40.52779  -8.81825  -104.88356 1.000 21.55839 ? 300 LEU A CD1 1 
ATOM   2460 C CD2 . LEU A 1 300 ? -38.15974  -8.66693  -105.60558 1.000 20.74757 ? 300 LEU A CD2 1 
ATOM   2461 N N   . ASP A 1 301 ? -36.94141  -7.29326  -100.46682 1.000 24.12170 ? 301 ASP A N   1 
ATOM   2462 C CA  . ASP A 1 301 ? -36.58501  -6.27748  -99.47852  1.000 30.20489 ? 301 ASP A CA  1 
ATOM   2463 C C   . ASP A 1 301 ? -35.27972  -5.59270  -99.84224  1.000 27.95918 ? 301 ASP A C   1 
ATOM   2464 O O   . ASP A 1 301 ? -35.09294  -4.41302  -99.53298  1.000 34.58837 ? 301 ASP A O   1 
ATOM   2465 C CB  . ASP A 1 301 ? -36.45821  -6.89364  -98.07758  1.000 22.08028 ? 301 ASP A CB  1 
ATOM   2466 C CG  . ASP A 1 301 ? -37.78996  -7.24407  -97.46531  1.000 34.00648 ? 301 ASP A CG  1 
ATOM   2467 O OD1 . ASP A 1 301 ? -38.82431  -6.71308  -97.91973  1.000 34.55035 ? 301 ASP A OD1 1 
ATOM   2468 O OD2 . ASP A 1 301 ? -37.79956  -8.04028  -96.50512  1.000 40.41847 ? 301 ASP A OD2 1 
ATOM   2469 N N   . ASN A 1 302 ? -34.37057  -6.30787  -100.50860 1.000 27.41241 ? 302 ASN A N   1 
ATOM   2470 C CA  . ASN A 1 302 ? -33.03150  -5.80222  -100.77230 1.000 32.30383 ? 302 ASN A CA  1 
ATOM   2471 C C   . ASN A 1 302 ? -32.65167  -5.77646  -102.24244 1.000 34.91209 ? 302 ASN A C   1 
ATOM   2472 O O   . ASN A 1 302 ? -31.51333  -5.40452  -102.56541 1.000 36.53887 ? 302 ASN A O   1 
ATOM   2473 C CB  . ASN A 1 302 ? -31.99966  -6.62654  -99.99056  1.000 31.10132 ? 302 ASN A CB  1 
ATOM   2474 C CG  . ASN A 1 302 ? -32.04506  -6.33163  -98.51254  1.000 33.59704 ? 302 ASN A CG  1 
ATOM   2475 O OD1 . ASN A 1 302 ? -31.87566  -5.18379  -98.10719  1.000 38.05866 ? 302 ASN A OD1 1 
ATOM   2476 N ND2 . ASN A 1 302 ? -32.29498  -7.35752  -97.69417  1.000 32.40715 ? 302 ASN A ND2 1 
ATOM   2477 N N   . PHE A 1 303 ? -33.55799  -6.17762  -103.13641 1.000 33.26682 ? 303 PHE A N   1 
ATOM   2478 C CA  . PHE A 1 303 ? -33.33304  -6.16661  -104.57087 1.000 29.86303 ? 303 PHE A CA  1 
ATOM   2479 C C   . PHE A 1 303 ? -34.59854  -5.62293  -105.23039 1.000 34.32018 ? 303 PHE A C   1 
ATOM   2480 O O   . PHE A 1 303 ? -35.71339  -6.06718  -104.89442 1.000 29.42321 ? 303 PHE A O   1 
ATOM   2481 C CB  . PHE A 1 303 ? -32.99453  -7.55861  -105.12859 1.000 27.88797 ? 303 PHE A CB  1 
ATOM   2482 C CG  . PHE A 1 303 ? -32.67349  -7.54908  -106.60071 1.000 32.34457 ? 303 PHE A CG  1 
ATOM   2483 C CD1 . PHE A 1 303 ? -31.37811  -7.29028  -107.03552 1.000 31.30279 ? 303 PHE A CD1 1 
ATOM   2484 C CD2 . PHE A 1 303 ? -33.66692  -7.76749  -107.54852 1.000 29.23142 ? 303 PHE A CD2 1 
ATOM   2485 C CE1 . PHE A 1 303 ? -31.06943  -7.25878  -108.38629 1.000 27.29605 ? 303 PHE A CE1 1 
ATOM   2486 C CE2 . PHE A 1 303 ? -33.37160  -7.74306  -108.90661 1.000 30.03219 ? 303 PHE A CE2 1 
ATOM   2487 C CZ  . PHE A 1 303 ? -32.06266  -7.48564  -109.32697 1.000 29.54162 ? 303 PHE A CZ  1 
ATOM   2488 N N   . PRO A 1 304 ? -34.47040  -4.69400  -106.18094 1.000 34.96335 ? 304 PRO A N   1 
ATOM   2489 C CA  . PRO A 1 304 ? -33.18829  -4.16709  -106.65527 1.000 33.58249 ? 304 PRO A CA  1 
ATOM   2490 C C   . PRO A 1 304 ? -32.64287  -3.00967  -105.82376 1.000 31.72015 ? 304 PRO A C   1 
ATOM   2491 O O   . PRO A 1 304 ? -31.60316  -2.46915  -106.20829 1.000 30.03670 ? 304 PRO A O   1 
ATOM   2492 C CB  . PRO A 1 304 ? -33.51824  -3.69398  -108.07058 1.000 29.20643 ? 304 PRO A CB  1 
ATOM   2493 C CG  . PRO A 1 304 ? -34.93367  -3.27905  -107.97888 1.000 32.83495 ? 304 PRO A CG  1 
ATOM   2494 C CD  . PRO A 1 304 ? -35.59347  -4.21571  -106.99830 1.000 29.91797 ? 304 PRO A CD  1 
ATOM   2495 N N   . VAL A 1 305 ? -33.32911  -2.63835  -104.74049 1.000 31.73702 ? 305 VAL A N   1 
ATOM   2496 C CA  . VAL A 1 305 ? -32.91316  -1.55485  -103.85064 1.000 35.88610 ? 305 VAL A CA  1 
ATOM   2497 C C   . VAL A 1 305 ? -32.55291  -2.15913  -102.50103 1.000 37.66617 ? 305 VAL A C   1 
ATOM   2498 O O   . VAL A 1 305 ? -33.39422  -2.79686  -101.85167 1.000 34.72203 ? 305 VAL A O   1 
ATOM   2499 C CB  . VAL A 1 305 ? -34.00915  -0.49475  -103.66995 1.000 40.90652 ? 305 VAL A CB  1 
ATOM   2500 C CG1 . VAL A 1 305 ? -33.49634  0.63730   -102.79127 1.000 38.82973 ? 305 VAL A CG1 1 
ATOM   2501 C CG2 . VAL A 1 305 ? -34.44512  0.04864   -104.98971 1.000 36.85152 ? 305 VAL A CG2 1 
ATOM   2502 N N   . HIS A 1 306 ? -31.31690  -1.93980  -102.06000 1.000 42.20408 ? 306 HIS A N   1 
ATOM   2503 C CA  . HIS A 1 306 ? -30.90690  -2.50012  -100.78257 1.000 38.41524 ? 306 HIS A CA  1 
ATOM   2504 C C   . HIS A 1 306 ? -31.58259  -1.77046  -99.62390  1.000 36.60644 ? 306 HIS A C   1 
ATOM   2505 O O   . HIS A 1 306 ? -31.78967  -0.55489  -99.65969  1.000 43.39126 ? 306 HIS A O   1 
ATOM   2506 C CB  . HIS A 1 306 ? -29.38668  -2.45704  -100.61981 1.000 34.59733 ? 306 HIS A CB  1 
ATOM   2507 C CG  . HIS A 1 306 ? -28.92479  -3.11438  -99.35445  1.000 50.95652 ? 306 HIS A CG  1 
ATOM   2508 N ND1 . HIS A 1 306 ? -28.96331  -2.48019  -98.12736  1.000 51.78980 ? 306 HIS A ND1 1 
ATOM   2509 C CD2 . HIS A 1 306 ? -28.50453  -4.37934  -99.10995  1.000 49.65705 ? 306 HIS A CD2 1 
ATOM   2510 C CE1 . HIS A 1 306 ? -28.54413  -3.31203  -97.18930  1.000 45.56287 ? 306 HIS A CE1 1 
ATOM   2511 N NE2 . HIS A 1 306 ? -28.26280  -4.47164  -97.75829  1.000 53.05579 ? 306 HIS A NE2 1 
ATOM   2512 N N   . GLY A 1 307 ? -31.96104  -2.53289  -98.60544  1.000 36.72835 ? 307 GLY A N   1 
ATOM   2513 C CA  . GLY A 1 307 ? -32.37684  -1.94896  -97.34938  1.000 33.07802 ? 307 GLY A CA  1 
ATOM   2514 C C   . GLY A 1 307 ? -33.75516  -1.33822  -97.30745  1.000 44.81652 ? 307 GLY A C   1 
ATOM   2515 O O   . GLY A 1 307 ? -34.00656  -0.48745  -96.45213  1.000 40.05319 ? 307 GLY A O   1 
ATOM   2516 N N   . ARG A 1 308 ? -34.66370  -1.73050  -98.19880  1.000 42.19598 ? 308 ARG A N   1 
ATOM   2517 C CA  . ARG A 1 308 ? -36.02501  -1.24154  -98.08835  1.000 29.69261 ? 308 ARG A CA  1 
ATOM   2518 C C   . ARG A 1 308 ? -36.93093  -2.40232  -97.67019  1.000 33.93586 ? 308 ARG A C   1 
ATOM   2519 O O   . ARG A 1 308 ? -36.45522  -3.40706  -97.12862  1.000 41.12881 ? 308 ARG A O   1 
ATOM   2520 C CB  . ARG A 1 308 ? -36.44635  -0.55031  -99.39588  1.000 36.44487 ? 308 ARG A CB  1 
ATOM   2521 C CG  . ARG A 1 308 ? -36.76918  -1.44125  -100.58741 1.000 33.46916 ? 308 ARG A CG  1 
ATOM   2522 C CD  . ARG A 1 308 ? -37.36146  -0.61404  -101.76905 1.000 35.37880 ? 308 ARG A CD  1 
ATOM   2523 N NE  . ARG A 1 308 ? -37.50496  -1.40344  -103.00080 1.000 35.12652 ? 308 ARG A NE  1 
ATOM   2524 C CZ  . ARG A 1 308 ? -37.86762  -0.91705  -104.19092 1.000 37.16198 ? 308 ARG A CZ  1 
ATOM   2525 N NH1 . ARG A 1 308 ? -38.12951  0.37694   -104.34018 1.000 30.94065 ? 308 ARG A NH1 1 
ATOM   2526 N NH2 . ARG A 1 308 ? -37.96392  -1.73197  -105.24676 1.000 26.77348 ? 308 ARG A NH2 1 
ATOM   2527 N N   . LYS A 1 309 ? -38.23169  -2.24797  -97.87276  1.000 22.53311 ? 309 LYS A N   1 
ATOM   2528 C CA  . LYS A 1 309 ? -39.18379  -3.28991  -97.53813  1.000 29.54925 ? 309 LYS A CA  1 
ATOM   2529 C C   . LYS A 1 309 ? -40.17763  -3.46179  -98.68398  1.000 27.87925 ? 309 LYS A C   1 
ATOM   2530 O O   . LYS A 1 309 ? -40.53763  -2.49117  -99.35354  1.000 27.85518 ? 309 LYS A O   1 
ATOM   2531 C CB  . LYS A 1 309 ? -39.91248  -2.96191  -96.23368  1.000 26.32131 ? 309 LYS A CB  1 
ATOM   2532 C CG  . LYS A 1 309 ? -40.75908  -4.11121  -95.69280  1.000 28.02691 ? 309 LYS A CG  1 
ATOM   2533 C CD  . LYS A 1 309 ? -39.87801  -5.23340  -95.17106  1.000 32.48219 ? 309 LYS A CD  1 
ATOM   2534 C CE  . LYS A 1 309 ? -40.71336  -6.42944  -94.73434  1.000 31.59680 ? 309 LYS A CE  1 
ATOM   2535 N NZ  . LYS A 1 309 ? -41.06598  -7.30908  -95.88597  1.000 28.55017 ? 309 LYS A NZ  1 
ATOM   2536 N N   . ASN A 1 310 ? -40.60088  -4.70473  -98.91684  1.000 28.93076 ? 310 ASN A N   1 
ATOM   2537 C CA  . ASN A 1 310 ? -41.55964  -5.05016  -99.95787  1.000 22.70504 ? 310 ASN A CA  1 
ATOM   2538 C C   . ASN A 1 310 ? -42.58436  -6.02115  -99.38398  1.000 30.28860 ? 310 ASN A C   1 
ATOM   2539 O O   . ASN A 1 310 ? -42.35361  -6.67034  -98.36181  1.000 28.64704 ? 310 ASN A O   1 
ATOM   2540 C CB  . ASN A 1 310 ? -40.85999  -5.66502  -101.18561 1.000 24.08180 ? 310 ASN A CB  1 
ATOM   2541 C CG  . ASN A 1 310 ? -41.56314  -5.32944  -102.49162 1.000 29.08474 ? 310 ASN A CG  1 
ATOM   2542 O OD1 . ASN A 1 310 ? -42.80269  -5.31578  -102.56633 1.000 27.48495 ? 310 ASN A OD1 1 
ATOM   2543 N ND2 . ASN A 1 310 ? -40.77057  -5.05011  -103.53327 1.000 17.44655 ? 310 ASN A ND2 1 
ATOM   2544 N N   . TRP A 1 311 ? -43.73605  -6.10724  -100.03866 1.000 26.03372 ? 311 TRP A N   1 
ATOM   2545 C CA  . TRP A 1 311 ? -44.86808  -6.88439  -99.53769  1.000 26.44217 ? 311 TRP A CA  1 
ATOM   2546 C C   . TRP A 1 311 ? -45.44325  -7.71645  -100.68599 1.000 31.48508 ? 311 TRP A C   1 
ATOM   2547 O O   . TRP A 1 311 ? -46.56067  -7.46909  -101.16293 1.000 24.92013 ? 311 TRP A O   1 
ATOM   2548 C CB  . TRP A 1 311 ? -45.90403  -5.94741  -98.91191  1.000 33.25400 ? 311 TRP A CB  1 
ATOM   2549 C CG  . TRP A 1 311 ? -45.27806  -4.97417  -97.92037  1.000 35.74187 ? 311 TRP A CG  1 
ATOM   2550 C CD1 . TRP A 1 311 ? -45.11171  -5.17282  -96.57373  1.000 31.21560 ? 311 TRP A CD1 1 
ATOM   2551 C CD2 . TRP A 1 311 ? -44.70711  -3.68078  -98.20431  1.000 27.70956 ? 311 TRP A CD2 1 
ATOM   2552 N NE1 . TRP A 1 311 ? -44.49560  -4.08796  -96.00916  1.000 24.75822 ? 311 TRP A NE1 1 
ATOM   2553 C CE2 . TRP A 1 311 ? -44.22812  -3.16086  -96.98187  1.000 30.83943 ? 311 TRP A CE2 1 
ATOM   2554 C CE3 . TRP A 1 311 ? -44.55601  -2.91737  -99.36677  1.000 27.70244 ? 311 TRP A CE3 1 
ATOM   2555 C CZ2 . TRP A 1 311 ? -43.61077  -1.90997  -96.88552  1.000 29.77647 ? 311 TRP A CZ2 1 
ATOM   2556 C CZ3 . TRP A 1 311 ? -43.93931  -1.67502  -99.27366  1.000 33.29280 ? 311 TRP A CZ3 1 
ATOM   2557 C CH2 . TRP A 1 311 ? -43.47713  -1.18198  -98.03851  1.000 34.62248 ? 311 TRP A CH2 1 
ATOM   2558 N N   . PRO A 1 312 ? -44.70034  -8.72409  -101.14495 1.000 27.24228 ? 312 PRO A N   1 
ATOM   2559 C CA  . PRO A 1 312 ? -44.97724  -9.34696  -102.45464 1.000 22.94090 ? 312 PRO A CA  1 
ATOM   2560 C C   . PRO A 1 312 ? -45.82300  -10.61096 -102.43965 1.000 25.29690 ? 312 PRO A C   1 
ATOM   2561 O O   . PRO A 1 312 ? -46.11794  -11.12832 -103.52492 1.000 21.72734 ? 312 PRO A O   1 
ATOM   2562 C CB  . PRO A 1 312 ? -43.56453  -9.68954  -102.95228 1.000 24.55410 ? 312 PRO A CB  1 
ATOM   2563 C CG  . PRO A 1 312 ? -42.57821  -9.24050  -101.82100 1.000 25.77972 ? 312 PRO A CG  1 
ATOM   2564 C CD  . PRO A 1 312 ? -43.41342  -9.18477  -100.59699 1.000 21.76483 ? 312 PRO A CD  1 
ATOM   2565 N N   . LEU A 1 313 ? -46.21728  -11.12419 -101.28248 1.000 21.42521 ? 313 LEU A N   1 
ATOM   2566 C CA  . LEU A 1 313 ? -46.73664  -12.48640 -101.22166 1.000 27.16853 ? 313 LEU A CA  1 
ATOM   2567 C C   . LEU A 1 313 ? -48.18006  -12.49365 -100.72629 1.000 27.04297 ? 313 LEU A C   1 
ATOM   2568 O O   . LEU A 1 313 ? -48.79600  -11.44742 -100.50223 1.000 29.33479 ? 313 LEU A O   1 
ATOM   2569 C CB  . LEU A 1 313 ? -45.82824  -13.35229 -100.34276 1.000 25.14188 ? 313 LEU A CB  1 
ATOM   2570 C CG  . LEU A 1 313 ? -44.39867  -13.35231 -100.91400 1.000 27.41205 ? 313 LEU A CG  1 
ATOM   2571 C CD1 . LEU A 1 313 ? -43.34128  -13.59632 -99.84186  1.000 21.06884 ? 313 LEU A CD1 1 
ATOM   2572 C CD2 . LEU A 1 313 ? -44.27167  -14.37182 -102.05297 1.000 24.23442 ? 313 LEU A CD2 1 
ATOM   2573 N N   . LEU A 1 314 ? -48.72572  -13.70196 -100.57563 1.000 24.26667 ? 314 LEU A N   1 
ATOM   2574 C CA  . LEU A 1 314 ? -50.12598  -13.85683 -100.20199 1.000 28.05299 ? 314 LEU A CA  1 
ATOM   2575 C C   . LEU A 1 314 ? -50.37843  -13.71918 -98.70285  1.000 30.10848 ? 314 LEU A C   1 
ATOM   2576 O O   . LEU A 1 314 ? -51.54903  -13.62183 -98.30917  1.000 28.45804 ? 314 LEU A O   1 
ATOM   2577 C CB  . LEU A 1 314 ? -50.65786  -15.21045 -100.67151 1.000 17.55367 ? 314 LEU A CB  1 
ATOM   2578 C CG  . LEU A 1 314 ? -50.81242  -15.47280 -102.16179 1.000 22.77103 ? 314 LEU A CG  1 
ATOM   2579 C CD1 . LEU A 1 314 ? -51.54158  -16.77352 -102.36378 1.000 16.75681 ? 314 LEU A CD1 1 
ATOM   2580 C CD2 . LEU A 1 314 ? -51.54092  -14.33567 -102.83572 1.000 24.38253 ? 314 LEU A CD2 1 
ATOM   2581 N N   . PHE A 1 315 ? -49.32676  -13.71724 -97.86626  1.000 24.18470 ? 315 PHE A N   1 
ATOM   2582 C CA  . PHE A 1 315 ? -49.45904  -13.62473 -96.41347  1.000 26.72741 ? 315 PHE A CA  1 
ATOM   2583 C C   . PHE A 1 315 ? -48.60221  -12.48270 -95.89679  1.000 23.42624 ? 315 PHE A C   1 
ATOM   2584 O O   . PHE A 1 315 ? -47.51179  -12.24151 -96.41733  1.000 30.38284 ? 315 PHE A O   1 
ATOM   2585 C CB  . PHE A 1 315 ? -49.04506  -14.93045 -95.71475  1.000 26.22103 ? 315 PHE A CB  1 
ATOM   2586 C CG  . PHE A 1 315 ? -49.82566  -16.12269 -96.15710  1.000 21.46228 ? 315 PHE A CG  1 
ATOM   2587 C CD1 . PHE A 1 315 ? -51.05422  -16.41556 -95.57920  1.000 20.37785 ? 315 PHE A CD1 1 
ATOM   2588 C CD2 . PHE A 1 315 ? -49.33818  -16.95247 -97.16276  1.000 22.51002 ? 315 PHE A CD2 1 
ATOM   2589 C CE1 . PHE A 1 315 ? -51.79060  -17.51699 -95.98687  1.000 19.15272 ? 315 PHE A CE1 1 
ATOM   2590 C CE2 . PHE A 1 315 ? -50.05875  -18.05521 -97.58057  1.000 18.80128 ? 315 PHE A CE2 1 
ATOM   2591 C CZ  . PHE A 1 315 ? -51.30596  -18.33250 -96.99834  1.000 26.12594 ? 315 PHE A CZ  1 
ATOM   2592 N N   . ASP A 1 316 ? -49.09224  -11.77724 -94.87508  1.000 25.20000 ? 316 ASP A N   1 
ATOM   2593 C CA  . ASP A 1 316 ? -48.35650  -10.62376 -94.36065  1.000 28.57381 ? 316 ASP A CA  1 
ATOM   2594 C C   . ASP A 1 316 ? -47.28675  -11.07588 -93.36554  1.000 28.36639 ? 316 ASP A C   1 
ATOM   2595 O O   . ASP A 1 316 ? -47.12544  -12.27293 -93.09971  1.000 26.06570 ? 316 ASP A O   1 
ATOM   2596 C CB  . ASP A 1 316 ? -49.30863  -9.59652  -93.74414  1.000 33.56492 ? 316 ASP A CB  1 
ATOM   2597 C CG  . ASP A 1 316 ? -50.12706  -10.14524 -92.56992  1.000 37.25817 ? 316 ASP A CG  1 
ATOM   2598 O OD1 . ASP A 1 316 ? -49.70682  -11.10960 -91.87759  1.000 29.57457 ? 316 ASP A OD1 1 
ATOM   2599 O OD2 . ASP A 1 316 ? -51.21880  -9.58046  -92.34113  1.000 41.76261 ? 316 ASP A OD2 1 
ATOM   2600 N N   . GLU A 1 317 ? -46.53328  -10.10496 -92.81443  1.000 32.43705 ? 317 GLU A N   1 
ATOM   2601 C CA  . GLU A 1 317 ? -45.42010  -10.43531 -91.91800  1.000 31.23200 ? 317 GLU A CA  1 
ATOM   2602 C C   . GLU A 1 317 ? -45.89204  -11.15479 -90.65924  1.000 32.42712 ? 317 GLU A C   1 
ATOM   2603 O O   . GLU A 1 317 ? -45.11322  -11.87425 -90.03175  1.000 37.78652 ? 317 GLU A O   1 
ATOM   2604 C CB  . GLU A 1 317 ? -44.62634  -9.17975  -91.53915  1.000 29.89631 ? 317 GLU A CB  1 
ATOM   2605 C CG  . GLU A 1 317 ? -44.04841  -8.44461  -92.72391  1.000 34.86910 ? 317 GLU A CG  1 
ATOM   2606 C CD  . GLU A 1 317 ? -43.57525  -7.04348  -92.39859  1.000 38.22101 ? 317 GLU A CD  1 
ATOM   2607 O OE1 . GLU A 1 317 ? -42.52496  -6.86728  -91.72139  1.000 41.49390 ? 317 GLU A OE1 1 
ATOM   2608 O OE2 . GLU A 1 317 ? -44.28332  -6.11069  -92.83738  1.000 41.67702 ? 317 GLU A OE2 1 
ATOM   2609 N N   . GLN A 1 318 ? -47.14601  -11.00859 -90.28901  1.000 30.62867 ? 318 GLN A N   1 
ATOM   2610 C CA  . GLN A 1 318 ? -47.67274  -11.78164 -89.18422  1.000 31.69996 ? 318 GLN A CA  1 
ATOM   2611 C C   . GLN A 1 318 ? -48.24312  -13.11110 -89.64054  1.000 32.17102 ? 318 GLN A C   1 
ATOM   2612 O O   . GLN A 1 318 ? -48.92624  -13.77249 -88.85364  1.000 30.27075 ? 318 GLN A O   1 
ATOM   2613 C CB  . GLN A 1 318 ? -48.72521  -10.96709 -88.43071  1.000 33.99709 ? 318 GLN A CB  1 
ATOM   2614 C CG  . GLN A 1 318 ? -48.13428  -9.79183  -87.63488  1.000 30.24328 ? 318 GLN A CG  1 
ATOM   2615 C CD  . GLN A 1 318 ? -47.71864  -8.61508  -88.51852  1.000 45.83652 ? 318 GLN A CD  1 
ATOM   2616 O OE1 . GLN A 1 318 ? -48.46108  -8.20242  -89.42185  1.000 48.35652 ? 318 GLN A OE1 1 
ATOM   2617 N NE2 . GLN A 1 318 ? -46.54082  -8.04742  -88.23778  1.000 35.31418 ? 318 GLN A NE2 1 
ATOM   2618 N N   . HIS A 1 319 ? -47.97157  -13.51120 -90.89118  1.000 30.06347 ? 319 HIS A N   1 
ATOM   2619 C CA  . HIS A 1 319 ? -48.44416  -14.77695 -91.47680  1.000 29.81554 ? 319 HIS A CA  1 
ATOM   2620 C C   . HIS A 1 319 ? -49.97078  -14.82932 -91.58264  1.000 30.22959 ? 319 HIS A C   1 
ATOM   2621 O O   . HIS A 1 319 ? -50.57251  -15.90884 -91.66974  1.000 31.30511 ? 319 HIS A O   1 
ATOM   2622 C CB  . HIS A 1 319 ? -47.90281  -15.99765 -90.71433  1.000 28.28367 ? 319 HIS A CB  1 
ATOM   2623 C CG  . HIS A 1 319 ? -46.40132  -16.05385 -90.64055  1.000 32.99610 ? 319 HIS A CG  1 
ATOM   2624 N ND1 . HIS A 1 319 ? -45.72345  -17.10595 -90.06030  1.000 27.82858 ? 319 HIS A ND1 1 
ATOM   2625 C CD2 . HIS A 1 319 ? -45.44928  -15.19542 -91.08389  1.000 30.12773 ? 319 HIS A CD2 1 
ATOM   2626 C CE1 . HIS A 1 319 ? -44.42049  -16.89479 -90.15491  1.000 35.10832 ? 319 HIS A CE1 1 
ATOM   2627 N NE2 . HIS A 1 319 ? -44.22681  -15.74187 -90.77095  1.000 28.19731 ? 319 HIS A NE2 1 
ATOM   2628 N N   . LYS A 1 320 ? -50.61795  -13.64874 -91.62593  1.000 30.67152 ? 320 LYS A N   1 
ATOM   2629 C CA  . LYS A 1 320 ? -52.06260  -13.64267 -91.85254  1.000 34.47127 ? 320 LYS A CA  1 
ATOM   2630 C C   . LYS A 1 320 ? -52.38093  -13.45162 -93.33294  1.000 28.11060 ? 320 LYS A C   1 
ATOM   2631 O O   . LYS A 1 320 ? -51.61681  -12.80712 -94.06106  1.000 34.34656 ? 320 LYS A O   1 
ATOM   2632 C CB  . LYS A 1 320 ? -52.71180  -12.52676 -91.03401  1.000 36.66330 ? 320 LYS A CB  1 
ATOM   2633 C CG  . LYS A 1 320 ? -52.37604  -12.63082 -89.53525  1.000 39.20110 ? 320 LYS A CG  1 
ATOM   2634 C CD  . LYS A 1 320 ? -53.04089  -13.85848 -88.92875  1.000 44.42652 ? 320 LYS A CD  1 
ATOM   2635 C CE  . LYS A 1 320 ? -54.56446  -13.63071 -88.86910  1.000 58.04885 ? 320 LYS A CE  1 
ATOM   2636 N NZ  . LYS A 1 320 ? -55.41426  -14.74406 -89.43000  1.000 40.10343 ? 320 LYS A NZ  1 
ATOM   2637 N N   . PRO A 1 321 ? -53.48993  -14.00415 -93.82776  1.000 31.98805 ? 321 PRO A N   1 
ATOM   2638 C CA  . PRO A 1 321 ? -53.80178  -13.86373 -95.26032  1.000 31.45010 ? 321 PRO A CA  1 
ATOM   2639 C C   . PRO A 1 321 ? -54.06030  -12.41373 -95.62945  1.000 34.28399 ? 321 PRO A C   1 
ATOM   2640 O O   . PRO A 1 321 ? -54.74005  -11.67731 -94.91145  1.000 35.84096 ? 321 PRO A O   1 
ATOM   2641 C CB  . PRO A 1 321 ? -55.05864  -14.71700 -95.44609  1.000 27.65074 ? 321 PRO A CB  1 
ATOM   2642 C CG  . PRO A 1 321 ? -55.65876  -14.82845 -94.09959  1.000 35.84252 ? 321 PRO A CG  1 
ATOM   2643 C CD  . PRO A 1 321 ? -54.50629  -14.79210 -93.11672  1.000 26.86739 ? 321 PRO A CD  1 
ATOM   2644 N N   . LYS A 1 322 ? -53.47837  -12.00295 -96.74010  1.000 28.73661 ? 322 LYS A N   1 
ATOM   2645 C CA  . LYS A 1 322 ? -53.69058  -10.67281 -97.27910  1.000 24.79110 ? 322 LYS A CA  1 
ATOM   2646 C C   . LYS A 1 322 ? -54.91702  -10.69112 -98.17405  1.000 31.38008 ? 322 LYS A C   1 
ATOM   2647 O O   . LYS A 1 322 ? -55.43403  -11.75596 -98.52209  1.000 25.89419 ? 322 LYS A O   1 
ATOM   2648 C CB  . LYS A 1 322 ? -52.44449  -10.22353 -98.03674  1.000 20.59371 ? 322 LYS A CB  1 
ATOM   2649 C CG  . LYS A 1 322 ? -51.25450  -9.93128  -97.13519  1.000 21.98633 ? 322 LYS A CG  1 
ATOM   2650 C CD  . LYS A 1 322 ? -49.95814  -10.02391 -97.91189  1.000 28.05872 ? 322 LYS A CD  1 
ATOM   2651 C CE  . LYS A 1 322 ? -49.84308  -8.90471  -98.93233  1.000 27.85381 ? 322 LYS A CE  1 
ATOM   2652 N NZ  . LYS A 1 322 ? -48.49550  -8.89077  -99.57613  1.000 22.79102 ? 322 LYS A NZ  1 
ATOM   2653 N N   . PRO A 1 323 ? -55.44284  -9.52360  -98.54952  1.000 31.17786 ? 323 PRO A N   1 
ATOM   2654 C CA  . PRO A 1 323 ? -56.56128  -9.53625  -99.50749  1.000 27.00139 ? 323 PRO A CA  1 
ATOM   2655 C C   . PRO A 1 323 ? -56.21868  -10.29701 -100.78140 1.000 28.94807 ? 323 PRO A C   1 
ATOM   2656 O O   . PRO A 1 323 ? -57.08183  -11.00007 -101.32585 1.000 29.65082 ? 323 PRO A O   1 
ATOM   2657 C CB  . PRO A 1 323 ? -56.82629  -8.04470  -99.76172  1.000 31.11472 ? 323 PRO A CB  1 
ATOM   2658 C CG  . PRO A 1 323 ? -56.28913  -7.34707  -98.55934  1.000 32.17936 ? 323 PRO A CG  1 
ATOM   2659 C CD  . PRO A 1 323 ? -55.13439  -8.16925  -98.05279  1.000 27.04368 ? 323 PRO A CD  1 
ATOM   2660 N N   . ALA A 1 324 ? -54.96090  -10.21105 -101.24188 1.000 27.01479 ? 324 ALA A N   1 
ATOM   2661 C CA  . ALA A 1 324 ? -54.49564  -11.03834 -102.35526 1.000 25.19655 ? 324 ALA A CA  1 
ATOM   2662 C C   . ALA A 1 324 ? -54.80918  -12.52147 -102.15036 1.000 30.62208 ? 324 ALA A C   1 
ATOM   2663 O O   . ALA A 1 324 ? -55.16650  -13.21842 -103.10399 1.000 31.39584 ? 324 ALA A O   1 
ATOM   2664 C CB  . ALA A 1 324 ? -52.99090  -10.84178 -102.55880 1.000 28.68762 ? 324 ALA A CB  1 
ATOM   2665 N N   . PHE A 1 325 ? -54.66791  -13.02852 -100.91895 1.000 25.70923 ? 325 PHE A N   1 
ATOM   2666 C CA  . PHE A 1 325 ? -54.95952  -14.43812 -100.66597 1.000 24.27444 ? 325 PHE A CA  1 
ATOM   2667 C C   . PHE A 1 325 ? -56.36708  -14.80572 -101.12589 1.000 28.55910 ? 325 PHE A C   1 
ATOM   2668 O O   . PHE A 1 325 ? -56.56874  -15.80779 -101.82434 1.000 36.06136 ? 325 PHE A O   1 
ATOM   2669 C CB  . PHE A 1 325 ? -54.78737  -14.76315 -99.17057  1.000 22.54476 ? 325 PHE A CB  1 
ATOM   2670 C CG  . PHE A 1 325 ? -55.23269  -16.15664 -98.80708  1.000 26.23862 ? 325 PHE A CG  1 
ATOM   2671 C CD1 . PHE A 1 325 ? -54.37012  -17.22869 -98.93256  1.000 25.86362 ? 325 PHE A CD1 1 
ATOM   2672 C CD2 . PHE A 1 325 ? -56.52055  -16.39825 -98.35919  1.000 27.02429 ? 325 PHE A CD2 1 
ATOM   2673 C CE1 . PHE A 1 325 ? -54.78069  -18.51367 -98.62106  1.000 23.48489 ? 325 PHE A CE1 1 
ATOM   2674 C CE2 . PHE A 1 325 ? -56.94313  -17.68548 -98.04219  1.000 30.91953 ? 325 PHE A CE2 1 
ATOM   2675 C CZ  . PHE A 1 325 ? -56.07636  -18.74312 -98.17154  1.000 31.88726 ? 325 PHE A CZ  1 
ATOM   2676 N N   . TRP A 1 326 ? -57.36073  -13.99526 -100.73825 1.000 29.97193 ? 326 TRP A N   1 
ATOM   2677 C CA  . TRP A 1 326 ? -58.76162  -14.36919 -100.94091 1.000 28.47207 ? 326 TRP A CA  1 
ATOM   2678 C C   . TRP A 1 326 ? -59.14257  -14.38858 -102.42151 1.000 24.82072 ? 326 TRP A C   1 
ATOM   2679 O O   . TRP A 1 326 ? -59.89631  -15.26689 -102.85676 1.000 27.66454 ? 326 TRP A O   1 
ATOM   2680 C CB  . TRP A 1 326 ? -59.66530  -13.42651 -100.14447 1.000 25.20992 ? 326 TRP A CB  1 
ATOM   2681 C CG  . TRP A 1 326 ? -59.41258  -13.53487 -98.66738  1.000 21.14648 ? 326 TRP A CG  1 
ATOM   2682 C CD1 . TRP A 1 326 ? -58.68168  -12.68131 -97.87761  1.000 20.66828 ? 326 TRP A CD1 1 
ATOM   2683 C CD2 . TRP A 1 326 ? -59.85499  -14.59226 -97.81746  1.000 18.44088 ? 326 TRP A CD2 1 
ATOM   2684 N NE1 . TRP A 1 326 ? -58.66021  -13.15019 -96.58100  1.000 21.99623 ? 326 TRP A NE1 1 
ATOM   2685 C CE2 . TRP A 1 326 ? -59.38021  -14.31985 -96.52560  1.000 21.85921 ? 326 TRP A CE2 1 
ATOM   2686 C CE3 . TRP A 1 326 ? -60.62750  -15.73827 -98.02789  1.000 28.25212 ? 326 TRP A CE3 1 
ATOM   2687 C CZ2 . TRP A 1 326 ? -59.66565  -15.14820 -95.44418  1.000 23.41890 ? 326 TRP A CZ2 1 
ATOM   2688 C CZ3 . TRP A 1 326 ? -60.89374  -16.55914 -96.97085  1.000 28.15532 ? 326 TRP A CZ3 1 
ATOM   2689 C CH2 . TRP A 1 326 ? -60.42024  -16.26351 -95.68876  1.000 23.32829 ? 326 TRP A CH2 1 
ATOM   2690 N N   . ARG A 1 327 ? -58.62586  -13.44043 -103.21938 1.000 26.86281 ? 327 ARG A N   1 
ATOM   2691 C CA  A ARG A 1 327 ? -58.87883  -13.48549 -104.65600 0.571 27.10951 ? 327 ARG A CA  1 
ATOM   2692 C CA  C ARG A 1 327 ? -58.87061  -13.47688 -104.66389 0.429 27.09355 ? 327 ARG A CA  1 
ATOM   2693 C C   . ARG A 1 327 ? -58.14224  -14.64546 -105.30659 1.000 27.25340 ? 327 ARG A C   1 
ATOM   2694 O O   . ARG A 1 327 ? -58.70450  -15.32369 -106.16729 1.000 26.91090 ? 327 ARG A O   1 
ATOM   2695 C CB  A ARG A 1 327 ? -58.49801  -12.15353 -105.28343 0.571 29.56533 ? 327 ARG A CB  1 
ATOM   2696 C CB  C ARG A 1 327 ? -58.48057  -12.14005 -105.30842 0.429 29.56167 ? 327 ARG A CB  1 
ATOM   2697 C CG  A ARG A 1 327 ? -59.20475  -10.98235 -104.60641 0.571 32.30767 ? 327 ARG A CG  1 
ATOM   2698 C CG  C ARG A 1 327 ? -59.17114  -10.93709 -104.60123 0.429 31.84833 ? 327 ARG A CG  1 
ATOM   2699 C CD  A ARG A 1 327 ? -59.04879  -9.64719  -105.33275 0.571 31.13899 ? 327 ARG A CD  1 
ATOM   2700 C CD  C ARG A 1 327 ? -59.19936  -9.57808  -105.34670 0.429 31.11284 ? 327 ARG A CD  1 
ATOM   2701 N NE  A ARG A 1 327 ? -59.62456  -9.60281  -106.67130 0.571 27.43780 ? 327 ARG A NE  1 
ATOM   2702 N NE  C ARG A 1 327 ? -59.80965  -8.40972  -104.64275 0.429 35.57830 ? 327 ARG A NE  1 
ATOM   2703 C CZ  A ARG A 1 327 ? -60.13060  -8.50400  -107.22755 0.571 24.55652 ? 327 ARG A CZ  1 
ATOM   2704 C CZ  C ARG A 1 327 ? -59.96309  -8.20866  -103.30862 0.429 44.43817 ? 327 ARG A CZ  1 
ATOM   2705 N NH1 A ARG A 1 327 ? -60.16641  -7.35910  -106.56115 0.571 27.13652 ? 327 ARG A NH1 1 
ATOM   2706 N NH1 C ARG A 1 327 ? -59.56296  -9.09393  -102.38261 0.429 44.93528 ? 327 ARG A NH1 1 
ATOM   2707 N NH2 A ARG A 1 327 ? -60.62628  -8.56307  -108.44848 0.571 22.32652 ? 327 ARG A NH2 1 
ATOM   2708 N NH2 C ARG A 1 327 ? -60.52000  -7.07260  -102.87080 0.429 22.32652 ? 327 ARG A NH2 1 
ATOM   2709 N N   . ALA A 1 328 ? -56.92058  -14.94208 -104.84999 1.000 31.66351 ? 328 ALA A N   1 
ATOM   2710 C CA  . ALA A 1 328 ? -56.15696  -16.02581 -105.45141 1.000 23.07401 ? 328 ALA A CA  1 
ATOM   2711 C C   . ALA A 1 328 ? -56.89452  -17.35447 -105.32485 1.000 27.91461 ? 328 ALA A C   1 
ATOM   2712 O O   . ALA A 1 328 ? -56.94712  -18.13486 -106.28125 1.000 25.08678 ? 328 ALA A O   1 
ATOM   2713 C CB  . ALA A 1 328 ? -54.76428  -16.09694 -104.81234 1.000 20.35520 ? 328 ALA A CB  1 
ATOM   2714 N N   . VAL A 1 329 ? -57.46456  -17.64314 -104.14913 1.000 31.07694 ? 329 VAL A N   1 
ATOM   2715 C CA  . VAL A 1 329 ? -58.09140  -18.95006 -103.96923 1.000 29.26601 ? 329 VAL A CA  1 
ATOM   2716 C C   . VAL A 1 329 ? -59.51512  -18.99641 -104.50050 1.000 33.52682 ? 329 VAL A C   1 
ATOM   2717 O O   . VAL A 1 329 ? -60.09752  -20.08876 -104.60017 1.000 34.11652 ? 329 VAL A O   1 
ATOM   2718 C CB  . VAL A 1 329 ? -58.09343  -19.38660 -102.49283 1.000 34.53539 ? 329 VAL A CB  1 
ATOM   2719 C CG1 . VAL A 1 329 ? -56.67285  -19.45844 -101.97304 1.000 32.43648 ? 329 VAL A CG1 1 
ATOM   2720 C CG2 . VAL A 1 329 ? -58.94163  -18.43876 -101.67050 1.000 28.54405 ? 329 VAL A CG2 1 
ATOM   2721 N N   . SER A 1 330 ? -60.10604  -17.85428 -104.84452 1.000 34.32325 ? 330 SER A N   1 
ATOM   2722 C CA  . SER A 1 330 ? -61.48907  -17.85069 -105.30135 1.000 38.20101 ? 330 SER A CA  1 
ATOM   2723 C C   . SER A 1 330 ? -61.62504  -17.80014 -106.81326 1.000 35.50455 ? 330 SER A C   1 
ATOM   2724 O O   . SER A 1 330 ? -62.72905  -17.55726 -107.30491 1.000 40.55655 ? 330 SER A O   1 
ATOM   2725 C CB  . SER A 1 330 ? -62.25884  -16.68295 -104.68939 1.000 28.84982 ? 330 SER A CB  1 
ATOM   2726 O OG  . SER A 1 330 ? -62.15429  -16.68172 -103.26997 1.000 38.32461 ? 330 SER A OG  1 
ATOM   2727 N N   . VAL A 1 331 ? -60.54536  -18.03942 -107.56300 1.000 36.49359 ? 331 VAL A N   1 
ATOM   2728 C CA  . VAL A 1 331 ? -60.63771  -18.13083 -109.02977 1.000 31.48651 ? 331 VAL A CA  1 
ATOM   2729 C C   . VAL A 1 331 ? -61.26988  -19.46693 -109.40430 1.000 35.12959 ? 331 VAL A C   1 
ATOM   2730 O O   . VAL A 1 331 ? -61.67770  -19.67294 -110.53835 1.000 38.45505 ? 331 VAL A O   1 
ATOM   2731 C CB  . VAL A 1 331 ? -59.25932  -17.96809 -109.72040 1.000 35.89690 ? 331 VAL A CB  1 
ATOM   2732 C CG1 . VAL A 1 331 ? -58.62158  -16.58250 -109.42701 1.000 30.74444 ? 331 VAL A CG1 1 
ATOM   2733 C CG2 . VAL A 1 331 ? -58.31883  -19.12242 -109.30418 1.000 25.92846 ? 331 VAL A CG2 1 
ATOM   2734 O OXT . VAL A 1 331 ? -61.37152  -20.35741 -108.55902 1.000 40.48042 ? 331 VAL A OXT 1 
ATOM   2735 N N   . SER B 1 4   ? -62.45774  -3.74221  -111.54509 1.000 45.86359 ? 4   SER B N   1 
ATOM   2736 C CA  . SER B 1 4   ? -63.80439  -4.25359  -111.81206 1.000 59.40340 ? 4   SER B CA  1 
ATOM   2737 C C   . SER B 1 4   ? -64.03108  -5.65425  -111.19763 1.000 64.45652 ? 4   SER B C   1 
ATOM   2738 O O   . SER B 1 4   ? -63.40416  -6.64179  -111.60445 1.000 63.86652 ? 4   SER B O   1 
ATOM   2739 C CB  . SER B 1 4   ? -64.05449  -4.27805  -113.32470 1.000 59.63035 ? 4   SER B CB  1 
ATOM   2740 O OG  . SER B 1 4   ? -65.22128  -5.00872  -113.65732 1.000 64.90681 ? 4   SER B OG  1 
ATOM   2741 N N   . LEU B 1 5   ? -64.92704  -5.72655  -110.20952 1.000 49.30951 ? 5   LEU B N   1 
ATOM   2742 C CA  . LEU B 1 5   ? -65.24227  -6.97616  -109.52719 1.000 43.79713 ? 5   LEU B CA  1 
ATOM   2743 C C   . LEU B 1 5   ? -66.22703  -7.81677  -110.34110 1.000 39.58776 ? 5   LEU B C   1 
ATOM   2744 O O   . LEU B 1 5   ? -66.94643  -7.29599  -111.19660 1.000 40.46948 ? 5   LEU B O   1 
ATOM   2745 C CB  . LEU B 1 5   ? -65.85124  -6.68025  -108.16048 1.000 45.96492 ? 5   LEU B CB  1 
ATOM   2746 C CG  . LEU B 1 5   ? -65.00546  -6.52881  -106.89641 1.000 44.15817 ? 5   LEU B CG  1 
ATOM   2747 C CD1 . LEU B 1 5   ? -63.89863  -5.51754  -107.08348 1.000 45.48750 ? 5   LEU B CD1 1 
ATOM   2748 C CD2 . LEU B 1 5   ? -65.92671  -6.11257  -105.76310 1.000 43.92788 ? 5   LEU B CD2 1 
ATOM   2749 N N   . PRO B 1 6   ? -66.27258  -9.12734  -110.10193 1.000 28.05554 ? 6   PRO B N   1 
ATOM   2750 C CA  . PRO B 1 6   ? -67.40037  -9.92100  -110.60910 1.000 30.68323 ? 6   PRO B CA  1 
ATOM   2751 C C   . PRO B 1 6   ? -68.71718  -9.37990  -110.06353 1.000 35.03260 ? 6   PRO B C   1 
ATOM   2752 O O   . PRO B 1 6   ? -68.81509  -8.99237  -108.89609 1.000 31.78710 ? 6   PRO B O   1 
ATOM   2753 C CB  . PRO B 1 6   ? -67.12502  -11.33589 -110.08074 1.000 23.28736 ? 6   PRO B CB  1 
ATOM   2754 C CG  . PRO B 1 6   ? -65.73166  -11.33812 -109.59275 1.000 30.16586 ? 6   PRO B CG  1 
ATOM   2755 C CD  . PRO B 1 6   ? -65.32797  -9.92000  -109.29960 1.000 29.52888 ? 6   PRO B CD  1 
ATOM   2756 N N   . SER B 1 7   ? -69.73562  -9.36706  -110.91567 1.000 29.98203 ? 7   SER B N   1 
ATOM   2757 C CA  . SER B 1 7   ? -71.06372  -8.88761  -110.54262 1.000 28.00939 ? 7   SER B CA  1 
ATOM   2758 C C   . SER B 1 7   ? -71.89247  -10.04752 -110.00406 1.000 28.85461 ? 7   SER B C   1 
ATOM   2759 O O   . SER B 1 7   ? -72.12077  -11.03364 -110.71604 1.000 27.83027 ? 7   SER B O   1 
ATOM   2760 C CB  . SER B 1 7   ? -71.76482  -8.25682  -111.74315 1.000 28.46170 ? 7   SER B CB  1 
ATOM   2761 O OG  . SER B 1 7   ? -73.06464  -7.84375  -111.39182 1.000 29.35093 ? 7   SER B OG  1 
ATOM   2762 N N   . LEU B 1 8   ? -72.37190  -9.90598  -108.76278 1.000 25.17741 ? 8   LEU B N   1 
ATOM   2763 C CA  . LEU B 1 8   ? -73.05449  -11.00677 -108.08728 1.000 21.09920 ? 8   LEU B CA  1 
ATOM   2764 C C   . LEU B 1 8   ? -74.19256  -11.58235 -108.92509 1.000 28.30469 ? 8   LEU B C   1 
ATOM   2765 O O   . LEU B 1 8   ? -74.34360  -12.80907 -109.01613 1.000 24.44222 ? 8   LEU B O   1 
ATOM   2766 C CB  . LEU B 1 8   ? -73.57686  -10.53452 -106.72478 1.000 27.97755 ? 8   LEU B CB  1 
ATOM   2767 C CG  . LEU B 1 8   ? -72.53865  -10.51858 -105.59150 1.000 34.62652 ? 8   LEU B CG  1 
ATOM   2768 C CD1 . LEU B 1 8   ? -73.10120  -9.84035  -104.35767 1.000 20.51508 ? 8   LEU B CD1 1 
ATOM   2769 C CD2 . LEU B 1 8   ? -72.06125  -11.94233 -105.27255 1.000 18.13701 ? 8   LEU B CD2 1 
ATOM   2770 N N   . ARG B 1 9   ? -75.00914  -10.71668 -109.54530 1.000 22.28829 ? 9   ARG B N   1 
ATOM   2771 C CA  . ARG B 1 9   ? -76.10530  -11.21803 -110.37462 1.000 35.92620 ? 9   ARG B CA  1 
ATOM   2772 C C   . ARG B 1 9   ? -75.59232  -11.95370 -111.61092 1.000 32.47460 ? 9   ARG B C   1 
ATOM   2773 O O   . ARG B 1 9   ? -76.23097  -12.91689 -112.05714 1.000 33.37797 ? 9   ARG B O   1 
ATOM   2774 C CB  . ARG B 1 9   ? -77.04629  -10.07557 -110.78784 1.000 31.65658 ? 9   ARG B CB  1 
ATOM   2775 C CG  . ARG B 1 9   ? -76.36794  -8.90582  -111.49185 1.000 27.18156 ? 9   ARG B CG  1 
ATOM   2776 C CD  . ARG B 1 9   ? -77.37702  -7.89256  -112.05612 1.000 33.08324 ? 9   ARG B CD  1 
ATOM   2777 N NE  . ARG B 1 9   ? -76.68583  -6.88169  -112.85834 1.000 20.71669 ? 9   ARG B NE  1 
ATOM   2778 C CZ  . ARG B 1 9   ? -76.26791  -5.71788  -112.37690 1.000 29.35216 ? 9   ARG B CZ  1 
ATOM   2779 N NH1 . ARG B 1 9   ? -76.50113  -5.39517  -111.10923 1.000 27.49263 ? 9   ARG B NH1 1 
ATOM   2780 N NH2 . ARG B 1 9   ? -75.63440  -4.86265  -113.16570 1.000 26.32045 ? 9   ARG B NH2 1 
ATOM   2781 N N   . ASP B 1 10  ? -74.44177  -11.53415 -112.16455 1.000 26.85723 ? 10  ASP B N   1 
ATOM   2782 C CA  . ASP B 1 10  ? -73.87912  -12.23976 -113.32061 1.000 33.04397 ? 10  ASP B CA  1 
ATOM   2783 C C   . ASP B 1 10  ? -73.27985  -13.57639 -112.91099 1.000 35.16293 ? 10  ASP B C   1 
ATOM   2784 O O   . ASP B 1 10  ? -73.43844  -14.57223 -113.62489 1.000 35.36894 ? 10  ASP B O   1 
ATOM   2785 C CB  . ASP B 1 10  ? -72.81850  -11.39254 -114.02213 1.000 27.88886 ? 10  ASP B CB  1 
ATOM   2786 C CG  . ASP B 1 10  ? -73.39729  -10.16327 -114.69797 1.000 35.04780 ? 10  ASP B CG  1 
ATOM   2787 O OD1 . ASP B 1 10  ? -74.60366  -10.18456 -115.04968 1.000 32.21470 ? 10  ASP B OD1 1 
ATOM   2788 O OD2 . ASP B 1 10  ? -72.64805  -9.17008  -114.85904 1.000 33.57824 ? 10  ASP B OD2 1 
ATOM   2789 N N   . VAL B 1 11  ? -72.59390  -13.61750 -111.76157 1.000 29.70207 ? 11  VAL B N   1 
ATOM   2790 C CA  . VAL B 1 11  ? -72.00203  -14.86469 -111.28038 1.000 30.85496 ? 11  VAL B CA  1 
ATOM   2791 C C   . VAL B 1 11  ? -73.07228  -15.93250 -111.09289 1.000 29.92709 ? 11  VAL B C   1 
ATOM   2792 O O   . VAL B 1 11  ? -72.84324  -17.11647 -111.36797 1.000 38.08008 ? 11  VAL B O   1 
ATOM   2793 C CB  . VAL B 1 11  ? -71.21308  -14.62367 -109.97538 1.000 31.36718 ? 11  VAL B CB  1 
ATOM   2794 C CG1 . VAL B 1 11  ? -70.69729  -15.94459 -109.40198 1.000 29.15897 ? 11  VAL B CG1 1 
ATOM   2795 C CG2 . VAL B 1 11  ? -70.06415  -13.68919 -110.21387 1.000 27.54157 ? 11  VAL B CG2 1 
ATOM   2796 N N   . PHE B 1 12  ? -74.26078  -15.53884 -110.63102 1.000 35.44778 ? 12  PHE B N   1 
ATOM   2797 C CA  . PHE B 1 12  ? -75.33226  -16.49323 -110.37165 1.000 30.16371 ? 12  PHE B CA  1 
ATOM   2798 C C   . PHE B 1 12  ? -76.47021  -16.37921 -111.37980 1.000 35.86300 ? 12  PHE B C   1 
ATOM   2799 O O   . PHE B 1 12  ? -77.58130  -16.84388 -111.10354 1.000 35.39357 ? 12  PHE B O   1 
ATOM   2800 C CB  . PHE B 1 12  ? -75.85089  -16.32015 -108.94878 1.000 31.35053 ? 12  PHE B CB  1 
ATOM   2801 C CG  . PHE B 1 12  ? -74.81992  -16.59844 -107.91147 1.000 25.88104 ? 12  PHE B CG  1 
ATOM   2802 C CD1 . PHE B 1 12  ? -74.48973  -17.89911 -107.59389 1.000 25.66447 ? 12  PHE B CD1 1 
ATOM   2803 C CD2 . PHE B 1 12  ? -74.15540  -15.55932 -107.27637 1.000 26.87165 ? 12  PHE B CD2 1 
ATOM   2804 C CE1 . PHE B 1 12  ? -73.52526  -18.16292 -106.63769 1.000 25.56189 ? 12  PHE B CE1 1 
ATOM   2805 C CE2 . PHE B 1 12  ? -73.18784  -15.80945 -106.32729 1.000 28.82046 ? 12  PHE B CE2 1 
ATOM   2806 C CZ  . PHE B 1 12  ? -72.86718  -17.11299 -106.00580 1.000 30.23224 ? 12  PHE B CZ  1 
ATOM   2807 N N   . ALA B 1 13  ? -76.19655  -15.78797 -112.55202 1.000 32.76756 ? 13  ALA B N   1 
ATOM   2808 C CA  . ALA B 1 13  ? -77.21054  -15.63281 -113.59272 1.000 38.57958 ? 13  ALA B CA  1 
ATOM   2809 C C   . ALA B 1 13  ? -77.99704  -16.91422 -113.82761 1.000 38.38550 ? 13  ALA B C   1 
ATOM   2810 O O   . ALA B 1 13  ? -79.22649  -16.88351 -113.95010 1.000 36.42647 ? 13  ALA B O   1 
ATOM   2811 C CB  . ALA B 1 13  ? -76.55709  -15.17352 -114.89181 1.000 27.14824 ? 13  ALA B CB  1 
ATOM   2812 N N   . ASN B 1 14  ? -77.31705  -18.05073 -113.87480 1.000 36.45365 ? 14  ASN B N   1 
ATOM   2813 C CA  . ASN B 1 14  ? -77.98760  -19.30172 -114.20054 1.000 41.73113 ? 14  ASN B CA  1 
ATOM   2814 C C   . ASN B 1 14  ? -78.56632  -20.00142 -112.99012 1.000 42.26986 ? 14  ASN B C   1 
ATOM   2815 O O   . ASN B 1 14  ? -79.13026  -21.08871 -113.13843 1.000 41.32948 ? 14  ASN B O   1 
ATOM   2816 C CB  . ASN B 1 14  ? -77.02682  -20.25941 -114.91897 1.000 49.95510 ? 14  ASN B CB  1 
ATOM   2817 C CG  . ASN B 1 14  ? -76.62815  -19.75637 -116.28945 1.000 54.33410 ? 14  ASN B CG  1 
ATOM   2818 O OD1 . ASN B 1 14  ? -75.45449  -19.48774 -116.54941 1.000 62.67007 ? 14  ASN B OD1 1 
ATOM   2819 N ND2 . ASN B 1 14  ? -77.61433  -19.60332 -117.17285 1.000 58.30115 ? 14  ASN B ND2 1 
ATOM   2820 N N   . ASP B 1 15  ? -78.44102  -19.42128 -111.80162 1.000 43.27290 ? 15  ASP B N   1 
ATOM   2821 C CA  . ASP B 1 15  ? -78.88319  -20.08545 -110.58364 1.000 39.17222 ? 15  ASP B CA  1 
ATOM   2822 C C   . ASP B 1 15  ? -80.05225  -19.38990 -109.90145 1.000 35.27451 ? 15  ASP B C   1 
ATOM   2823 O O   . ASP B 1 15  ? -81.02499  -20.05346 -109.52816 1.000 30.51272 ? 15  ASP B O   1 
ATOM   2824 C CB  . ASP B 1 15  ? -77.69081  -20.21194 -109.63038 1.000 36.81749 ? 15  ASP B CB  1 
ATOM   2825 C CG  . ASP B 1 15  ? -76.49104  -20.84413 -110.30752 1.000 44.27948 ? 15  ASP B CG  1 
ATOM   2826 O OD1 . ASP B 1 15  ? -76.68250  -21.84871 -111.02763 1.000 52.36493 ? 15  ASP B OD1 1 
ATOM   2827 O OD2 . ASP B 1 15  ? -75.36413  -20.32794 -110.14886 1.000 46.98612 ? 15  ASP B OD2 1 
ATOM   2828 N N   . PHE B 1 16  ? -79.99038  -18.06911 -109.73019 1.000 31.76061 ? 16  PHE B N   1 
ATOM   2829 C CA  . PHE B 1 16  ? -81.02829  -17.33201 -109.01591 1.000 31.14641 ? 16  PHE B CA  1 
ATOM   2830 C C   . PHE B 1 16  ? -80.70342  -15.84714 -109.07358 1.000 28.67327 ? 16  PHE B C   1 
ATOM   2831 O O   . PHE B 1 16  ? -79.56340  -15.44623 -109.33943 1.000 28.02903 ? 16  PHE B O   1 
ATOM   2832 C CB  . PHE B 1 16  ? -81.16393  -17.77974 -107.54663 1.000 32.37535 ? 16  PHE B CB  1 
ATOM   2833 C CG  . PHE B 1 16  ? -79.87443  -18.25283 -106.93166 1.000 31.48738 ? 16  PHE B CG  1 
ATOM   2834 C CD1 . PHE B 1 16  ? -78.84575  -17.36133 -106.67445 1.000 24.71556 ? 16  PHE B CD1 1 
ATOM   2835 C CD2 . PHE B 1 16  ? -79.69424  -19.59424 -106.61308 1.000 33.18709 ? 16  PHE B CD2 1 
ATOM   2836 C CE1 . PHE B 1 16  ? -77.65422  -17.79285 -106.12273 1.000 24.55307 ? 16  PHE B CE1 1 
ATOM   2837 C CE2 . PHE B 1 16  ? -78.50613  -20.03790 -106.05235 1.000 32.70328 ? 16  PHE B CE2 1 
ATOM   2838 C CZ  . PHE B 1 16  ? -77.48151  -19.13727 -105.80780 1.000 30.05421 ? 16  PHE B CZ  1 
ATOM   2839 N N   . ARG B 1 17  ? -81.73212  -15.03783 -108.84322 1.000 27.02055 ? 17  ARG B N   1 
ATOM   2840 C CA  . ARG B 1 17  ? -81.53891  -13.60203 -108.72888 1.000 31.85139 ? 17  ARG B CA  1 
ATOM   2841 C C   . ARG B 1 17  ? -80.80257  -13.26864 -107.43116 1.000 30.99954 ? 17  ARG B C   1 
ATOM   2842 O O   . ARG B 1 17  ? -80.85914  -14.00531 -106.44141 1.000 28.56710 ? 17  ARG B O   1 
ATOM   2843 C CB  . ARG B 1 17  ? -82.88520  -12.87467 -108.77058 1.000 29.84369 ? 17  ARG B CB  1 
ATOM   2844 C CG  . ARG B 1 17  ? -83.66701  -13.02923 -110.07882 1.000 29.56348 ? 17  ARG B CG  1 
ATOM   2845 C CD  . ARG B 1 17  ? -84.86720  -12.07559 -110.10292 1.000 36.75291 ? 17  ARG B CD  1 
ATOM   2846 N NE  . ARG B 1 17  ? -85.53214  -11.99486 -111.40585 1.000 37.07478 ? 17  ARG B NE  1 
ATOM   2847 C CZ  . ARG B 1 17  ? -85.32091  -11.04764 -112.32489 1.000 40.95063 ? 17  ARG B CZ  1 
ATOM   2848 N NH1 . ARG B 1 17  ? -84.46876  -10.04610 -112.10263 1.000 33.20016 ? 17  ARG B NH1 1 
ATOM   2849 N NH2 . ARG B 1 17  ? -85.98726  -11.09418 -113.47670 1.000 36.78070 ? 17  ARG B NH2 1 
ATOM   2850 N N   . ILE B 1 18  ? -80.09660  -12.14858 -107.44293 1.000 25.75050 ? 18  ILE B N   1 
ATOM   2851 C CA  . ILE B 1 18  ? -79.41999  -11.63804 -106.26151 1.000 28.50458 ? 18  ILE B CA  1 
ATOM   2852 C C   . ILE B 1 18  ? -80.09272  -10.33090 -105.87684 1.000 29.31285 ? 18  ILE B C   1 
ATOM   2853 O O   . ILE B 1 18  ? -80.09494  -9.37810  -106.66636 1.000 29.33951 ? 18  ILE B O   1 
ATOM   2854 C CB  . ILE B 1 18  ? -77.91443  -11.43363 -106.50365 1.000 24.28702 ? 18  ILE B CB  1 
ATOM   2855 C CG1 . ILE B 1 18  ? -77.24796  -12.77789 -106.77754 1.000 31.45020 ? 18  ILE B CG1 1 
ATOM   2856 C CG2 . ILE B 1 18  ? -77.27760  -10.79086 -105.28982 1.000 25.47576 ? 18  ILE B CG2 1 
ATOM   2857 C CD1 . ILE B 1 18  ? -77.34144  -13.72722 -105.61321 1.000 25.95370 ? 18  ILE B CD1 1 
ATOM   2858 N N   . GLY B 1 19  ? -80.64356  -10.27264 -104.65883 1.000 27.65176 ? 19  GLY B N   1 
ATOM   2859 C CA  . GLY B 1 19  ? -81.39651  -9.12427  -104.21322 1.000 25.15037 ? 19  GLY B CA  1 
ATOM   2860 C C   . GLY B 1 19  ? -80.75699  -8.42553  -103.02435 1.000 24.36350 ? 19  GLY B C   1 
ATOM   2861 O O   . GLY B 1 19  ? -79.87355  -8.96558  -102.35825 1.000 25.15350 ? 19  GLY B O   1 
ATOM   2862 N N   . ALA B 1 20  ? -81.25475  -7.21335  -102.74672 1.000 25.45059 ? 20  ALA B N   1 
ATOM   2863 C CA  . ALA B 1 20  ? -80.93157  -6.46824  -101.53356 1.000 21.29529 ? 20  ALA B CA  1 
ATOM   2864 C C   . ALA B 1 20  ? -82.18450  -5.81279  -100.95666 1.000 24.90822 ? 20  ALA B C   1 
ATOM   2865 O O   . ALA B 1 20  ? -83.03302  -5.32351  -101.70774 1.000 19.64294 ? 20  ALA B O   1 
ATOM   2866 C CB  . ALA B 1 20  ? -79.87905  -5.39423  -101.80867 1.000 18.53709 ? 20  ALA B CB  1 
ATOM   2867 N N   . ALA B 1 21  ? -82.29338  -5.80733  -99.62217  1.000 17.48543 ? 21  ALA B N   1 
ATOM   2868 C CA  . ALA B 1 21  ? -83.23806  -4.93697  -98.92360  1.000 16.21086 ? 21  ALA B CA  1 
ATOM   2869 C C   . ALA B 1 21  ? -82.68805  -3.51696  -98.85419  1.000 20.49805 ? 21  ALA B C   1 
ATOM   2870 O O   . ALA B 1 21  ? -81.50865  -3.30848  -98.55951  1.000 23.61129 ? 21  ALA B O   1 
ATOM   2871 C CB  . ALA B 1 21  ? -83.50545  -5.44316  -97.51035  1.000 20.60493 ? 21  ALA B CB  1 
ATOM   2872 N N   . VAL B 1 22  ? -83.54830  -2.53328  -99.13692  1.000 23.33967 ? 22  VAL B N   1 
ATOM   2873 C CA  . VAL B 1 22  ? -83.14402  -1.13586  -99.25088  1.000 23.41455 ? 22  VAL B CA  1 
ATOM   2874 C C   . VAL B 1 22  ? -84.22702  -0.24794  -98.64434  1.000 24.55146 ? 22  VAL B C   1 
ATOM   2875 O O   . VAL B 1 22  ? -85.35972  -0.67678  -98.41060  1.000 30.43370 ? 22  VAL B O   1 
ATOM   2876 C CB  . VAL B 1 22  ? -82.90225  -0.70985  -100.72932 1.000 25.65859 ? 22  VAL B CB  1 
ATOM   2877 C CG1 . VAL B 1 22  ? -81.88523  -1.61545  -101.46168 1.000 15.09651 ? 22  VAL B CG1 1 
ATOM   2878 C CG2 . VAL B 1 22  ? -84.19576  -0.70754  -101.46453 1.000 23.26265 ? 22  VAL B CG2 1 
ATOM   2879 N N   . ASN B 1 23  ? -83.86422  1.00206   -98.38739  1.000 26.27095 ? 23  ASN B N   1 
ATOM   2880 C CA  . ASN B 1 23  ? -84.79669  2.09843   -98.16512  1.000 29.64339 ? 23  ASN B CA  1 
ATOM   2881 C C   . ASN B 1 23  ? -84.31090  3.25243   -99.02648  1.000 31.21803 ? 23  ASN B C   1 
ATOM   2882 O O   . ASN B 1 23  ? -83.24777  3.16028   -99.64426  1.000 33.81853 ? 23  ASN B O   1 
ATOM   2883 C CB  . ASN B 1 23  ? -84.89585  2.47527   -96.67165  1.000 29.58410 ? 23  ASN B CB  1 
ATOM   2884 C CG  . ASN B 1 23  ? -83.55542  2.81788   -96.03925  1.000 31.53853 ? 23  ASN B CG  1 
ATOM   2885 O OD1 . ASN B 1 23  ? -82.80458  3.64883   -96.55419  1.000 33.50626 ? 23  ASN B OD1 1 
ATOM   2886 N ND2 . ASN B 1 23  ? -83.26777  2.20480   -94.88470  1.000 28.39824 ? 23  ASN B ND2 1 
ATOM   2887 N N   . PRO B 1 24  ? -85.08834  4.33764   -99.14874  1.000 33.53145 ? 24  PRO B N   1 
ATOM   2888 C CA  . PRO B 1 24  ? -84.62791  5.43623   -100.02080 1.000 36.08154 ? 24  PRO B CA  1 
ATOM   2889 C C   . PRO B 1 24  ? -83.27505  6.01168   -99.62907  1.000 34.18870 ? 24  PRO B C   1 
ATOM   2890 O O   . PRO B 1 24  ? -82.55022  6.49975   -100.50763 1.000 34.87508 ? 24  PRO B O   1 
ATOM   2891 C CB  . PRO B 1 24  ? -85.75237  6.47460   -99.89694  1.000 35.00818 ? 24  PRO B CB  1 
ATOM   2892 C CG  . PRO B 1 24  ? -86.96632  5.64613   -99.68284  1.000 32.98827 ? 24  PRO B CG  1 
ATOM   2893 C CD  . PRO B 1 24  ? -86.49764  4.53776   -98.75116  1.000 39.95968 ? 24  PRO B CD  1 
ATOM   2894 N N   . VAL B 1 25  ? -82.89716  5.95191   -98.34873  1.000 31.52937 ? 25  VAL B N   1 
ATOM   2895 C CA  . VAL B 1 25  ? -81.59396  6.47813   -97.93898  1.000 30.58429 ? 25  VAL B CA  1 
ATOM   2896 C C   . VAL B 1 25  ? -80.46415  5.54888   -98.38422  1.000 30.37353 ? 25  VAL B C   1 
ATOM   2897 O O   . VAL B 1 25  ? -79.45822  5.99916   -98.94423  1.000 33.48130 ? 25  VAL B O   1 
ATOM   2898 C CB  . VAL B 1 25  ? -81.56392  6.72988   -96.42074  1.000 29.89942 ? 25  VAL B CB  1 
ATOM   2899 C CG1 . VAL B 1 25  ? -80.15931  6.85558   -95.94424  1.000 30.41461 ? 25  VAL B CG1 1 
ATOM   2900 C CG2 . VAL B 1 25  ? -82.33395  8.00459   -96.08037  1.000 39.25029 ? 25  VAL B CG2 1 
ATOM   2901 N N   . THR B 1 26  ? -80.60395  4.23916   -98.14653  1.000 31.88781 ? 26  THR B N   1 
ATOM   2902 C CA  . THR B 1 26  ? -79.52006  3.33114   -98.51633  1.000 28.44848 ? 26  THR B CA  1 
ATOM   2903 C C   . THR B 1 26  ? -79.41193  3.16433   -100.01873 1.000 35.29774 ? 26  THR B C   1 
ATOM   2904 O O   . THR B 1 26  ? -78.33560  2.81332   -100.51698 1.000 32.90327 ? 26  THR B O   1 
ATOM   2905 C CB  . THR B 1 26  ? -79.68188  1.96395   -97.85895  1.000 32.63182 ? 26  THR B CB  1 
ATOM   2906 O OG1 . THR B 1 26  ? -80.88411  1.33448   -98.33015  1.000 25.89987 ? 26  THR B OG1 1 
ATOM   2907 C CG2 . THR B 1 26  ? -79.68285  2.09612   -96.33321  1.000 24.19752 ? 26  THR B CG2 1 
ATOM   2908 N N   . ILE B 1 27  ? -80.49011  3.42659   -100.75202 1.000 28.78465 ? 27  ILE B N   1 
ATOM   2909 C CA  . ILE B 1 27  ? -80.37868  3.50774   -102.20133 1.000 29.97131 ? 27  ILE B CA  1 
ATOM   2910 C C   . ILE B 1 27  ? -79.36888  4.58004   -102.59774 1.000 34.06287 ? 27  ILE B C   1 
ATOM   2911 O O   . ILE B 1 27  ? -78.54087  4.36238   -103.48334 1.000 40.14111 ? 27  ILE B O   1 
ATOM   2912 C CB  . ILE B 1 27  ? -81.76297  3.74642   -102.82908 1.000 34.18066 ? 27  ILE B CB  1 
ATOM   2913 C CG1 . ILE B 1 27  ? -82.53326  2.42798   -102.87239 1.000 32.70521 ? 27  ILE B CG1 1 
ATOM   2914 C CG2 . ILE B 1 27  ? -81.62284  4.29837   -104.22365 1.000 36.89147 ? 27  ILE B CG2 1 
ATOM   2915 C CD1 . ILE B 1 27  ? -83.88749  2.54538   -103.51434 1.000 30.13869 ? 27  ILE B CD1 1 
ATOM   2916 N N   . GLU B 1 28  ? -79.40062  5.74404   -101.94262 1.000 31.12926 ? 28  GLU B N   1 
ATOM   2917 C CA  . GLU B 1 28  ? -78.40390  6.77155   -102.25062 1.000 37.03864 ? 28  GLU B CA  1 
ATOM   2918 C C   . GLU B 1 28  ? -77.03287  6.39651   -101.70903 1.000 32.53337 ? 28  GLU B C   1 
ATOM   2919 O O   . GLU B 1 28  ? -76.01817  6.58374   -102.38849 1.000 42.02652 ? 28  GLU B O   1 
ATOM   2920 C CB  . GLU B 1 28  ? -78.82414  8.12881   -101.68647 1.000 31.86220 ? 28  GLU B CB  1 
ATOM   2921 C CG  . GLU B 1 28  ? -80.04544  8.70840   -102.37264 1.000 52.19290 ? 28  GLU B CG  1 
ATOM   2922 C CD  . GLU B 1 28  ? -79.88409  8.75832   -103.87951 1.000 56.01753 ? 28  GLU B CD  1 
ATOM   2923 O OE1 . GLU B 1 28  ? -78.78180  9.13717   -104.34537 1.000 46.61963 ? 28  GLU B OE1 1 
ATOM   2924 O OE2 . GLU B 1 28  ? -80.85696  8.39260   -104.58910 1.000 60.64582 ? 28  GLU B OE2 1 
ATOM   2925 N N   . MET B 1 29  ? -76.98894  5.86897   -100.48612 1.000 32.94905 ? 29  MET B N   1 
ATOM   2926 C CA  . MET B 1 29  ? -75.72147  5.60559   -99.81748  1.000 32.78033 ? 29  MET B CA  1 
ATOM   2927 C C   . MET B 1 29  ? -74.98067  4.42839   -100.44655 1.000 33.21205 ? 29  MET B C   1 
ATOM   2928 O O   . MET B 1 29  ? -73.74653  4.43079   -100.49916 1.000 41.53044 ? 29  MET B O   1 
ATOM   2929 C CB  . MET B 1 29  ? -75.98611  5.35056   -98.33712  1.000 33.16922 ? 29  MET B CB  1 
ATOM   2930 C CG  . MET B 1 29  ? -74.76530  5.07279   -97.50156  1.000 38.13242 ? 29  MET B CG  1 
ATOM   2931 S SD  . MET B 1 29  ? -75.24887  4.78982   -95.78681  1.000 46.57227 ? 29  MET B SD  1 
ATOM   2932 C CE  . MET B 1 29  ? -75.64165  3.05306   -95.93398  1.000 39.40086 ? 29  MET B CE  1 
ATOM   2933 N N   . GLN B 1 30  ? -75.70805  3.43148   -100.94510 1.000 31.02045 ? 30  GLN B N   1 
ATOM   2934 C CA  . GLN B 1 30  ? -75.13404  2.20969   -101.49699 1.000 27.72264 ? 30  GLN B CA  1 
ATOM   2935 C C   . GLN B 1 30  ? -75.44670  2.04757   -102.98336 1.000 26.10956 ? 30  GLN B C   1 
ATOM   2936 O O   . GLN B 1 30  ? -75.47026  0.92306   -103.49655 1.000 24.44782 ? 30  GLN B O   1 
ATOM   2937 C CB  . GLN B 1 30  ? -75.63468  0.99387   -100.71515 1.000 22.70866 ? 30  GLN B CB  1 
ATOM   2938 C CG  . GLN B 1 30  ? -75.40683  1.10851   -99.21116  1.000 25.51645 ? 30  GLN B CG  1 
ATOM   2939 C CD  . GLN B 1 30  ? -76.04345  -0.02725  -98.42745  1.000 33.36430 ? 30  GLN B CD  1 
ATOM   2940 O OE1 . GLN B 1 30  ? -77.16919  -0.45269  -98.72307  1.000 28.55984 ? 30  GLN B OE1 1 
ATOM   2941 N NE2 . GLN B 1 30  ? -75.32897  -0.52263  -97.41532  1.000 25.21553 ? 30  GLN B NE2 1 
ATOM   2942 N N   . LYS B 1 31  ? -75.66402  3.16333   -103.69139 1.000 26.52128 ? 31  LYS B N   1 
ATOM   2943 C CA  . LYS B 1 31  ? -76.21800  3.09240   -105.04468 1.000 28.04118 ? 31  LYS B CA  1 
ATOM   2944 C C   . LYS B 1 31  ? -75.33006  2.27354   -105.97676 1.000 32.13090 ? 31  LYS B C   1 
ATOM   2945 O O   . LYS B 1 31  ? -75.82110  1.43976   -106.74903 1.000 31.47218 ? 31  LYS B O   1 
ATOM   2946 C CB  . LYS B 1 31  ? -76.42952  4.50059   -105.60662 1.000 25.59371 ? 31  LYS B CB  1 
ATOM   2947 C CG  . LYS B 1 31  ? -77.13268  4.51447   -106.95709 1.000 30.37555 ? 31  LYS B CG  1 
ATOM   2948 C CD  . LYS B 1 31  ? -77.41785  5.92658   -107.43321 1.000 39.28287 ? 31  LYS B CD  1 
ATOM   2949 C CE  . LYS B 1 31  ? -78.68481  6.48202   -106.81201 1.000 45.86683 ? 31  LYS B CE  1 
ATOM   2950 N NZ  . LYS B 1 31  ? -79.06175  7.80136   -107.38684 1.000 51.91290 ? 31  LYS B NZ  1 
ATOM   2951 N N   . GLN B 1 32  ? -74.01581  2.49110   -105.92293 1.000 28.79827 ? 32  GLN B N   1 
ATOM   2952 C CA  . GLN B 1 32  ? -73.16371  1.85030   -106.91767 1.000 33.90329 ? 32  GLN B CA  1 
ATOM   2953 C C   . GLN B 1 32  ? -73.08959  0.34395   -106.68426 1.000 28.00718 ? 32  GLN B C   1 
ATOM   2954 O O   . GLN B 1 32  ? -73.14054  -0.44422  -107.63762 1.000 28.68239 ? 32  GLN B O   1 
ATOM   2955 C CB  . GLN B 1 32  ? -71.77064  2.48972   -106.91059 1.000 38.75502 ? 32  GLN B CB  1 
ATOM   2956 C CG  . GLN B 1 32  ? -70.95156  2.17921   -108.16139 1.000 34.52335 ? 32  GLN B CG  1 
ATOM   2957 C CD  . GLN B 1 32  ? -71.64473  2.63569   -109.43177 1.000 37.29059 ? 32  GLN B CD  1 
ATOM   2958 O OE1 . GLN B 1 32  ? -71.97293  3.80628   -109.56602 1.000 42.21371 ? 32  GLN B OE1 1 
ATOM   2959 N NE2 . GLN B 1 32  ? -71.87808  1.70816   -110.36775 1.000 28.96746 ? 32  GLN B NE2 1 
ATOM   2960 N N   . LEU B 1 33  ? -72.97572  -0.07264  -105.42253 1.000 24.05106 ? 33  LEU B N   1 
ATOM   2961 C CA  . LEU B 1 33  ? -73.02831  -1.49675  -105.10124 1.000 27.93591 ? 33  LEU B CA  1 
ATOM   2962 C C   . LEU B 1 33  ? -74.28584  -2.14934  -105.66238 1.000 26.88892 ? 33  LEU B C   1 
ATOM   2963 O O   . LEU B 1 33  ? -74.22498  -3.24679  -106.23270 1.000 27.85371 ? 33  LEU B O   1 
ATOM   2964 C CB  . LEU B 1 33  ? -72.97937  -1.69439  -103.58548 1.000 27.20722 ? 33  LEU B CB  1 
ATOM   2965 C CG  . LEU B 1 33  ? -71.64232  -1.79407  -102.86058 1.000 33.40047 ? 33  LEU B CG  1 
ATOM   2966 C CD1 . LEU B 1 33  ? -71.91659  -1.99879  -101.38222 1.000 22.85478 ? 33  LEU B CD1 1 
ATOM   2967 C CD2 . LEU B 1 33  ? -70.74132  -2.92200  -103.42937 1.000 28.67644 ? 33  LEU B CD2 1 
ATOM   2968 N N   . LEU B 1 34  ? -75.44380  -1.49249  -105.49630 1.000 25.41945 ? 34  LEU B N   1 
ATOM   2969 C CA  . LEU B 1 34  ? -76.69736  -2.08586  -105.94970 1.000 23.31599 ? 34  LEU B CA  1 
ATOM   2970 C C   . LEU B 1 34  ? -76.71113  -2.20120  -107.45830 1.000 23.32710 ? 34  LEU B C   1 
ATOM   2971 O O   . LEU B 1 34  ? -76.96036  -3.28023  -108.00687 1.000 25.18515 ? 34  LEU B O   1 
ATOM   2972 C CB  . LEU B 1 34  ? -77.88568  -1.25391  -105.47971 1.000 29.72986 ? 34  LEU B CB  1 
ATOM   2973 C CG  . LEU B 1 34  ? -78.04545  -1.14869  -103.97468 1.000 21.45000 ? 34  LEU B CG  1 
ATOM   2974 C CD1 . LEU B 1 34  ? -78.88314  0.06731   -103.67425 1.000 28.29059 ? 34  LEU B CD1 1 
ATOM   2975 C CD2 . LEU B 1 34  ? -78.67533  -2.40380  -103.45327 1.000 19.41216 ? 34  LEU B CD2 1 
ATOM   2976 N N   . ILE B 1 35  ? -76.41637  -1.09565  -108.14054 1.000 24.41236 ? 35  ILE B N   1 
ATOM   2977 C CA  . ILE B 1 35  ? -76.34250  -1.10289  -109.60027 1.000 23.51594 ? 35  ILE B CA  1 
ATOM   2978 C C   . ILE B 1 35  ? -75.39969  -2.19635  -110.08305 1.000 31.11127 ? 35  ILE B C   1 
ATOM   2979 O O   . ILE B 1 35  ? -75.72441  -2.95743  -111.00401 1.000 27.95765 ? 35  ILE B O   1 
ATOM   2980 C CB  . ILE B 1 35  ? -75.91071  0.28051   -110.11597 1.000 32.42098 ? 35  ILE B CB  1 
ATOM   2981 C CG1 . ILE B 1 35  ? -77.01317  1.29659   -109.81661 1.000 25.87666 ? 35  ILE B CG1 1 
ATOM   2982 C CG2 . ILE B 1 35  ? -75.55081  0.20285   -111.60655 1.000 31.72872 ? 35  ILE B CG2 1 
ATOM   2983 C CD1 . ILE B 1 35  ? -76.64809  2.72650   -110.11895 1.000 35.53345 ? 35  ILE B CD1 1 
ATOM   2984 N N   . ASP B 1 36  ? -74.23191  -2.32482  -109.43252 1.000 32.51298 ? 36  ASP B N   1 
ATOM   2985 C CA  . ASP B 1 36  ? -73.22536  -3.25029  -109.94456 1.000 26.47540 ? 36  ASP B CA  1 
ATOM   2986 C C   . ASP B 1 36  ? -73.59136  -4.70568  -109.68602 1.000 25.94867 ? 36  ASP B C   1 
ATOM   2987 O O   . ASP B 1 36  ? -73.22271  -5.57368  -110.48572 1.000 28.56557 ? 36  ASP B O   1 
ATOM   2988 C CB  . ASP B 1 36  ? -71.85094  -2.93803  -109.35294 1.000 25.17648 ? 36  ASP B CB  1 
ATOM   2989 C CG  . ASP B 1 36  ? -71.28070  -1.60168  -109.83754 1.000 28.35376 ? 36  ASP B CG  1 
ATOM   2990 O OD1 . ASP B 1 36  ? -71.69209  -1.09607  -110.91485 1.000 28.75637 ? 36  ASP B OD1 1 
ATOM   2991 O OD2 . ASP B 1 36  ? -70.40938  -1.05153  -109.13153 1.000 34.41089 ? 36  ASP B OD2 1 
ATOM   2992 N N   . HIS B 1 37  ? -74.35073  -5.00432  -108.62347 1.000 25.59037 ? 37  HIS B N   1 
ATOM   2993 C CA  . HIS B 1 37  ? -74.46623  -6.40232  -108.21090 1.000 22.72410 ? 37  HIS B CA  1 
ATOM   2994 C C   . HIS B 1 37  ? -75.85517  -7.01895  -108.22135 1.000 22.81887 ? 37  HIS B C   1 
ATOM   2995 O O   . HIS B 1 37  ? -75.95107  -8.22012  -108.47285 1.000 31.11574 ? 37  HIS B O   1 
ATOM   2996 C CB  . HIS B 1 37  ? -73.86474  -6.57912  -106.81795 1.000 26.15754 ? 37  HIS B CB  1 
ATOM   2997 C CG  . HIS B 1 37  ? -72.38012  -6.41774  -106.80900 1.000 26.16930 ? 37  HIS B CG  1 
ATOM   2998 N ND1 . HIS B 1 37  ? -71.53376  -7.35760  -107.35460 1.000 28.64415 ? 37  HIS B ND1 1 
ATOM   2999 C CD2 . HIS B 1 37  ? -71.59331  -5.39682  -106.38562 1.000 25.23392 ? 37  HIS B CD2 1 
ATOM   3000 C CE1 . HIS B 1 37  ? -70.28219  -6.94249  -107.22737 1.000 29.93821 ? 37  HIS B CE1 1 
ATOM   3001 N NE2 . HIS B 1 37  ? -70.29025  -5.75372  -106.64799 1.000 28.45035 ? 37  HIS B NE2 1 
ATOM   3002 N N   . VAL B 1 38  ? -76.92956  -6.27902  -107.94671 1.000 21.70457 ? 38  VAL B N   1 
ATOM   3003 C CA  . VAL B 1 38  ? -78.21349  -6.93515  -107.70449 1.000 27.64716 ? 38  VAL B CA  1 
ATOM   3004 C C   . VAL B 1 38  ? -79.11290  -6.79452  -108.91849 1.000 24.99947 ? 38  VAL B C   1 
ATOM   3005 O O   . VAL B 1 38  ? -78.97332  -5.87203  -109.73301 1.000 26.27714 ? 38  VAL B O   1 
ATOM   3006 C CB  . VAL B 1 38  ? -78.89251  -6.39531  -106.41923 1.000 22.99130 ? 38  VAL B CB  1 
ATOM   3007 C CG1 . VAL B 1 38  ? -77.84876  -6.29061  -105.29944 1.000 19.15544 ? 38  VAL B CG1 1 
ATOM   3008 C CG2 . VAL B 1 38  ? -79.55081  -5.03806  -106.64599 1.000 19.69492 ? 38  VAL B CG2 1 
ATOM   3009 N N   . ASN B 1 39  ? -80.03416  -7.75438  -109.05820 1.000 26.30973 ? 39  ASN B N   1 
ATOM   3010 C CA  . ASN B 1 39  ? -81.13684  -7.64647  -110.00905 1.000 33.12026 ? 39  ASN B CA  1 
ATOM   3011 C C   . ASN B 1 39  ? -82.47960  -7.84580  -109.31259 1.000 31.30063 ? 39  ASN B C   1 
ATOM   3012 O O   . ASN B 1 39  ? -83.46962  -8.21111  -109.96387 1.000 30.41440 ? 39  ASN B O   1 
ATOM   3013 C CB  . ASN B 1 39  ? -80.98683  -8.63179  -111.17986 1.000 22.38161 ? 39  ASN B CB  1 
ATOM   3014 C CG  . ASN B 1 39  ? -80.78108  -10.06536 -110.72619 1.000 30.97261 ? 39  ASN B CG  1 
ATOM   3015 O OD1 . ASN B 1 39  ? -80.87819  -10.39134 -109.52894 1.000 29.09700 ? 39  ASN B OD1 1 
ATOM   3016 N ND2 . ASN B 1 39  ? -80.49588  -10.93812 -111.68689 1.000 28.42042 ? 39  ASN B ND2 1 
ATOM   3017 N N   . SER B 1 40  ? -82.53386  -7.62356  -108.00143 1.000 19.72369 ? 40  SER B N   1 
ATOM   3018 C CA  . SER B 1 40  ? -83.81090  -7.62810  -107.32222 1.000 23.53697 ? 40  SER B CA  1 
ATOM   3019 C C   . SER B 1 40  ? -83.65299  -6.76686  -106.07623 1.000 26.99131 ? 40  SER B C   1 
ATOM   3020 O O   . SER B 1 40  ? -82.54270  -6.56959  -105.56971 1.000 28.54974 ? 40  SER B O   1 
ATOM   3021 C CB  . SER B 1 40  ? -84.25462  -9.06927  -107.04327 1.000 21.85029 ? 40  SER B CB  1 
ATOM   3022 O OG  . SER B 1 40  ? -85.36168  -9.18872  -106.17162 1.000 23.13938 ? 40  SER B OG  1 
ATOM   3023 N N   . ILE B 1 41  ? -84.76980  -6.21413  -105.62303 1.000 17.06168 ? 41  ILE B N   1 
ATOM   3024 C CA  . ILE B 1 41  ? -84.81997  -5.18393  -104.59226 1.000 20.15213 ? 41  ILE B CA  1 
ATOM   3025 C C   . ILE B 1 41  ? -86.01300  -5.50226  -103.69917 1.000 20.59164 ? 41  ILE B C   1 
ATOM   3026 O O   . ILE B 1 41  ? -87.08926  -5.84152  -104.20262 1.000 25.39707 ? 41  ILE B O   1 
ATOM   3027 C CB  . ILE B 1 41  ? -84.96718  -3.78098  -105.22989 1.000 31.08471 ? 41  ILE B CB  1 
ATOM   3028 C CG1 . ILE B 1 41  ? -83.66699  -3.35468  -105.89841 1.000 32.77943 ? 41  ILE B CG1 1 
ATOM   3029 C CG2 . ILE B 1 41  ? -85.42227  -2.72707  -104.22903 1.000 26.37586 ? 41  ILE B CG2 1 
ATOM   3030 C CD1 . ILE B 1 41  ? -82.56714  -3.07905  -104.93059 1.000 19.75759 ? 41  ILE B CD1 1 
ATOM   3031 N N   . THR B 1 42  ? -85.82845  -5.42239  -102.38629 1.000 23.34306 ? 42  THR B N   1 
ATOM   3032 C CA  . THR B 1 42  ? -86.94173  -5.48715  -101.44852 1.000 14.72151 ? 42  THR B CA  1 
ATOM   3033 C C   . THR B 1 42  ? -86.93161  -4.23169  -100.59103 1.000 22.14184 ? 42  THR B C   1 
ATOM   3034 O O   . THR B 1 42  ? -85.86202  -3.71710  -100.24592 1.000 25.84695 ? 42  THR B O   1 
ATOM   3035 C CB  . THR B 1 42  ? -86.87179  -6.72342  -100.56748 1.000 17.60326 ? 42  THR B CB  1 
ATOM   3036 O OG1 . THR B 1 42  ? -86.76719  -7.90153  -101.38065 1.000 20.87886 ? 42  THR B OG1 1 
ATOM   3037 C CG2 . THR B 1 42  ? -88.11561  -6.83266  -99.69974  1.000 17.01977 ? 42  THR B CG2 1 
ATOM   3038 N N   . ALA B 1 43  ? -88.11627  -3.71622  -100.26178 1.000 22.68587 ? 43  ALA B N   1 
ATOM   3039 C CA  . ALA B 1 43  ? -88.18893  -2.59652  -99.33180  1.000 17.38378 ? 43  ALA B CA  1 
ATOM   3040 C C   . ALA B 1 43  ? -88.01556  -3.13814  -97.91895  1.000 26.08601 ? 43  ALA B C   1 
ATOM   3041 O O   . ALA B 1 43  ? -88.81330  -3.96358  -97.45717  1.000 21.33951 ? 43  ALA B O   1 
ATOM   3042 C CB  . ALA B 1 43  ? -89.50589  -1.83542  -99.46720  1.000 20.47231 ? 43  ALA B CB  1 
ATOM   3043 N N   . GLU B 1 44  ? -86.95386  -2.69847  -97.24693  1.000 20.89018 ? 44  GLU B N   1 
ATOM   3044 C CA  . GLU B 1 44  ? -86.70235  -3.17049  -95.89187  1.000 22.22808 ? 44  GLU B CA  1 
ATOM   3045 C C   . GLU B 1 44  ? -87.87499  -2.84811  -94.97075  1.000 21.75273 ? 44  GLU B C   1 
ATOM   3046 O O   . GLU B 1 44  ? -88.28598  -3.68509  -94.15867  1.000 27.16305 ? 44  GLU B O   1 
ATOM   3047 C CB  . GLU B 1 44  ? -85.39772  -2.56349  -95.36343  1.000 18.05858 ? 44  GLU B CB  1 
ATOM   3048 C CG  . GLU B 1 44  ? -85.02522  -3.03964  -93.96107  1.000 22.13902 ? 44  GLU B CG  1 
ATOM   3049 C CD  . GLU B 1 44  ? -83.63259  -2.58693  -93.51578  1.000 23.37518 ? 44  GLU B CD  1 
ATOM   3050 O OE1 . GLU B 1 44  ? -82.98415  -1.78044  -94.21621  1.000 22.81783 ? 44  GLU B OE1 1 
ATOM   3051 O OE2 . GLU B 1 44  ? -83.18675  -3.02344  -92.43853  1.000 25.62455 ? 44  GLU B OE2 1 
ATOM   3052 N N   . ASN B 1 45  ? -88.45147  -1.65319  -95.09346  1.000 19.61673 ? 45  ASN B N   1 
ATOM   3053 C CA  . ASN B 1 45  ? -89.57618  -1.30016  -94.23557  1.000 21.92504 ? 45  ASN B CA  1 
ATOM   3054 C C   . ASN B 1 45  ? -90.76216  -0.62667  -94.93200  1.000 29.23576 ? 45  ASN B C   1 
ATOM   3055 O O   . ASN B 1 45  ? -91.86642  -0.69579  -94.38588  1.000 26.91068 ? 45  ASN B O   1 
ATOM   3056 C CB  . ASN B 1 45  ? -89.11274  -0.38135  -93.10227  1.000 21.06432 ? 45  ASN B CB  1 
ATOM   3057 C CG  . ASN B 1 45  ? -88.33094  -1.11676  -92.03020  1.000 30.15816 ? 45  ASN B CG  1 
ATOM   3058 O OD1 . ASN B 1 45  ? -88.88317  -1.91719  -91.27370  1.000 27.17424 ? 45  ASN B OD1 1 
ATOM   3059 N ND2 . ASN B 1 45  ? -87.03038  -0.83176  -91.95463  1.000 23.02217 ? 45  ASN B ND2 1 
ATOM   3060 N N   . HIS B 1 46  ? -90.59160  0.00786   -96.09738  1.000 20.74102 ? 46  HIS B N   1 
ATOM   3061 C CA  . HIS B 1 46  ? -91.55777  0.99578   -96.55899  1.000 26.77195 ? 46  HIS B CA  1 
ATOM   3062 C C   . HIS B 1 46  ? -92.70114  0.41879   -97.39802  1.000 24.83775 ? 46  HIS B C   1 
ATOM   3063 O O   . HIS B 1 46  ? -93.51164  1.18711   -97.92864  1.000 22.36303 ? 46  HIS B O   1 
ATOM   3064 C CB  . HIS B 1 46  ? -90.84036  2.11468   -97.31656  1.000 20.18227 ? 46  HIS B CB  1 
ATOM   3065 C CG  . HIS B 1 46  ? -90.03467  3.00606   -96.42124  1.000 30.90019 ? 46  HIS B CG  1 
ATOM   3066 N ND1 . HIS B 1 46  ? -88.66823  2.87049   -96.26794  1.000 32.80307 ? 46  HIS B ND1 1 
ATOM   3067 C CD2 . HIS B 1 46  ? -90.41052  4.01130   -95.59256  1.000 25.73524 ? 46  HIS B CD2 1 
ATOM   3068 C CE1 . HIS B 1 46  ? -88.23794  3.77149   -95.40096  1.000 39.81130 ? 46  HIS B CE1 1 
ATOM   3069 N NE2 . HIS B 1 46  ? -89.27383  4.47484   -94.97514  1.000 31.01163 ? 46  HIS B NE2 1 
ATOM   3070 N N   . MET B 1 47  ? -92.81441  -0.90145  -97.50409  1.000 20.33984 ? 47  MET B N   1 
ATOM   3071 C CA  . MET B 1 47  ? -94.04603  -1.50917  -97.98684  1.000 18.88084 ? 47  MET B CA  1 
ATOM   3072 C C   . MET B 1 47  ? -94.73763  -2.30488  -96.88852  1.000 24.41268 ? 47  MET B C   1 
ATOM   3073 O O   . MET B 1 47  ? -95.61768  -3.12348  -97.16884  1.000 29.18557 ? 47  MET B O   1 
ATOM   3074 C CB  . MET B 1 47  ? -93.77319  -2.37249  -99.21613  1.000 17.49861 ? 47  MET B CB  1 
ATOM   3075 C CG  . MET B 1 47  ? -93.28151  -1.53388  -100.40281 1.000 13.99284 ? 47  MET B CG  1 
ATOM   3076 S SD  . MET B 1 47  ? -93.04893  -2.49326  -101.90643 1.000 22.62275 ? 47  MET B SD  1 
ATOM   3077 C CE  . MET B 1 47  ? -92.22952  -1.27170  -102.90836 1.000 16.21931 ? 47  MET B CE  1 
ATOM   3078 N N   . LYS B 1 48  ? -94.36719  -2.07145  -95.63443  1.000 26.77809 ? 48  LYS B N   1 
ATOM   3079 C CA  . LYS B 1 48  ? -95.12677  -2.68096  -94.56405  1.000 25.96661 ? 48  LYS B CA  1 
ATOM   3080 C C   . LYS B 1 48  ? -96.38040  -1.85496  -94.29744  1.000 27.27314 ? 48  LYS B C   1 
ATOM   3081 O O   . LYS B 1 48  ? -96.49172  -0.69825  -94.71179  1.000 23.50641 ? 48  LYS B O   1 
ATOM   3082 C CB  . LYS B 1 48  ? -94.26557  -2.81644  -93.31271  1.000 21.16981 ? 48  LYS B CB  1 
ATOM   3083 C CG  . LYS B 1 48  ? -93.14653  -3.79111  -93.50760  1.000 23.11795 ? 48  LYS B CG  1 
ATOM   3084 C CD  . LYS B 1 48  ? -92.08062  -3.64796  -92.43473  1.000 17.10089 ? 48  LYS B CD  1 
ATOM   3085 C CE  . LYS B 1 48  ? -91.02930  -4.72609  -92.63768  1.000 24.16179 ? 48  LYS B CE  1 
ATOM   3086 N NZ  . LYS B 1 48  ? -89.88256  -4.57075  -91.71973  1.000 21.29736 ? 48  LYS B NZ  1 
ATOM   3087 N N   . PHE B 1 49  ? -97.33717  -2.46845  -93.60357  1.000 22.63942 ? 49  PHE B N   1 
ATOM   3088 C CA  . PHE B 1 49  ? -98.65703  -1.86014  -93.49222  1.000 24.38944 ? 49  PHE B CA  1 
ATOM   3089 C C   . PHE B 1 49  ? -98.56869  -0.44235  -92.93896  1.000 28.42777 ? 49  PHE B C   1 
ATOM   3090 O O   . PHE B 1 49  ? -99.17934  0.48673   -93.48414  1.000 26.04327 ? 49  PHE B O   1 
ATOM   3091 C CB  . PHE B 1 49  ? -99.55820  -2.73587  -92.62557  1.000 24.10520 ? 49  PHE B CB  1 
ATOM   3092 C CG  . PHE B 1 49  ? -101.03562 -2.48047  -92.81876  1.000 24.35218 ? 49  PHE B CG  1 
ATOM   3093 C CD1 . PHE B 1 49  ? -101.58872 -1.23081  -92.54545  1.000 22.48676 ? 49  PHE B CD1 1 
ATOM   3094 C CD2 . PHE B 1 49  ? -101.87923 -3.50764  -93.23805  1.000 20.72945 ? 49  PHE B CD2 1 
ATOM   3095 C CE1 . PHE B 1 49  ? -102.95477 -1.00884  -92.70182  1.000 24.59845 ? 49  PHE B CE1 1 
ATOM   3096 C CE2 . PHE B 1 49  ? -103.24531 -3.29966  -93.38131  1.000 21.37904 ? 49  PHE B CE2 1 
ATOM   3097 C CZ  . PHE B 1 49  ? -103.78359 -2.04966  -93.11953  1.000 20.58799 ? 49  PHE B CZ  1 
ATOM   3098 N N   . GLU B 1 50  ? -97.79315  -0.25263  -91.86753  1.000 26.40640 ? 50  GLU B N   1 
ATOM   3099 C CA  . GLU B 1 50  ? -97.72373  1.04818   -91.21846  1.000 23.45580 ? 50  GLU B CA  1 
ATOM   3100 C C   . GLU B 1 50  ? -97.09864  2.10301   -92.11239  1.000 24.48611 ? 50  GLU B C   1 
ATOM   3101 O O   . GLU B 1 50  ? -97.32103  3.30050   -91.88849  1.000 24.75496 ? 50  GLU B O   1 
ATOM   3102 C CB  . GLU B 1 50  ? -96.92678  0.95572   -89.90935  1.000 26.25691 ? 50  GLU B CB  1 
ATOM   3103 C CG  . GLU B 1 50  ? -95.43763  0.77689   -90.12814  1.000 25.64337 ? 50  GLU B CG  1 
ATOM   3104 C CD  . GLU B 1 50  ? -94.65343  0.60516   -88.83030  1.000 30.58956 ? 50  GLU B CD  1 
ATOM   3105 O OE1 . GLU B 1 50  ? -95.29012  0.49290   -87.76971  1.000 26.45883 ? 50  GLU B OE1 1 
ATOM   3106 O OE2 . GLU B 1 50  ? -93.40124  0.57131   -88.87761  1.000 32.47426 ? 50  GLU B OE2 1 
ATOM   3107 N N   . HIS B 1 51  ? -96.32297  1.69729   -93.11136  1.000 20.45931 ? 51  HIS B N   1 
ATOM   3108 C CA  . HIS B 1 51  ? -95.66467  2.65189   -93.98944  1.000 26.85512 ? 51  HIS B CA  1 
ATOM   3109 C C   . HIS B 1 51  ? -96.42471  2.90218   -95.28048  1.000 27.57848 ? 51  HIS B C   1 
ATOM   3110 O O   . HIS B 1 51  ? -96.02070  3.76613   -96.06982  1.000 25.59237 ? 51  HIS B O   1 
ATOM   3111 C CB  . HIS B 1 51  ? -94.24442  2.18595   -94.28671  1.000 23.96618 ? 51  HIS B CB  1 
ATOM   3112 C CG  . HIS B 1 51  ? -93.32494  2.39065   -93.12965  1.000 33.48067 ? 51  HIS B CG  1 
ATOM   3113 N ND1 . HIS B 1 51  ? -93.02625  3.64497   -92.64315  1.000 33.02379 ? 51  HIS B ND1 1 
ATOM   3114 C CD2 . HIS B 1 51  ? -92.68557  1.50770   -92.32501  1.000 28.49083 ? 51  HIS B CD2 1 
ATOM   3115 C CE1 . HIS B 1 51  ? -92.21675  3.52631   -91.60366  1.000 32.39307 ? 51  HIS B CE1 1 
ATOM   3116 N NE2 . HIS B 1 51  ? -91.99906  2.24095   -91.38751  1.000 32.89556 ? 51  HIS B NE2 1 
ATOM   3117 N N   . LEU B 1 52  ? -97.52530  2.20027   -95.49784  1.000 26.85528 ? 52  LEU B N   1 
ATOM   3118 C CA  . LEU B 1 52  ? -98.35164  2.40344   -96.67373  1.000 25.87008 ? 52  LEU B CA  1 
ATOM   3119 C C   . LEU B 1 52  ? -99.72107  2.98176   -96.34538  1.000 27.02449 ? 52  LEU B C   1 
ATOM   3120 O O   . LEU B 1 52  ? -100.20027 3.85220   -97.06606  1.000 22.55271 ? 52  LEU B O   1 
ATOM   3121 C CB  . LEU B 1 52  ? -98.51050  1.07739   -97.42300  1.000 21.74020 ? 52  LEU B CB  1 
ATOM   3122 C CG  . LEU B 1 52  ? -97.24447  0.54567   -98.09490  1.000 21.87867 ? 52  LEU B CG  1 
ATOM   3123 C CD1 . LEU B 1 52  ? -97.52245  -0.73471  -98.87150  1.000 13.56043 ? 52  LEU B CD1 1 
ATOM   3124 C CD2 . LEU B 1 52  ? -96.65352  1.60318   -99.00374  1.000 18.77423 ? 52  LEU B CD2 1 
ATOM   3125 N N   . GLN B 1 53  ? -100.36674 2.53853   -95.26961  1.000 28.80926 ? 53  GLN B N   1 
ATOM   3126 C CA  . GLN B 1 53  ? -101.66134 3.07539   -94.84683  1.000 25.22194 ? 53  GLN B CA  1 
ATOM   3127 C C   . GLN B 1 53  ? -101.61369 3.39769   -93.35729  1.000 24.05789 ? 53  GLN B C   1 
ATOM   3128 O O   . GLN B 1 53  ? -102.18147 2.66431   -92.53555  1.000 22.88531 ? 53  GLN B O   1 
ATOM   3129 C CB  . GLN B 1 53  ? -102.79366 2.09336   -95.15839  1.000 20.48935 ? 53  GLN B CB  1 
ATOM   3130 C CG  . GLN B 1 53  ? -104.07981 2.80549   -95.54941  1.000 23.31569 ? 53  GLN B CG  1 
ATOM   3131 C CD  . GLN B 1 53  ? -105.31970 1.94400   -95.44289  1.000 21.34844 ? 53  GLN B CD  1 
ATOM   3132 O OE1 . GLN B 1 53  ? -106.39260 2.45591   -95.17010  1.000 28.92502 ? 53  GLN B OE1 1 
ATOM   3133 N NE2 . GLN B 1 53  ? -105.18043 0.63710   -95.65427  1.000 22.86149 ? 53  GLN B NE2 1 
ATOM   3134 N N   . PRO B 1 54  ? -100.93284 4.48641   -92.97126  1.000 27.18428 ? 54  PRO B N   1 
ATOM   3135 C CA  . PRO B 1 54  ? -100.79960 4.79833   -91.53252  1.000 29.13616 ? 54  PRO B CA  1 
ATOM   3136 C C   . PRO B 1 54  ? -102.11437 5.14042   -90.84402  1.000 34.48043 ? 54  PRO B C   1 
ATOM   3137 O O   . PRO B 1 54  ? -102.24439 4.92403   -89.62852  1.000 30.20889 ? 54  PRO B O   1 
ATOM   3138 C CB  . PRO B 1 54  ? -99.83716  5.99718   -91.52299  1.000 23.75102 ? 54  PRO B CB  1 
ATOM   3139 C CG  . PRO B 1 54  ? -99.93198  6.57550   -92.92571  1.000 24.50435 ? 54  PRO B CG  1 
ATOM   3140 C CD  . PRO B 1 54  ? -100.09260 5.36969   -93.79948  1.000 19.70300 ? 54  PRO B CD  1 
ATOM   3141 N N   . GLU B 1 55  ? -103.06836 5.72019   -91.56870  1.000 31.20678 ? 55  GLU B N   1 
ATOM   3142 C CA  . GLU B 1 55  ? -104.42493 5.92845   -91.08542  1.000 30.40137 ? 55  GLU B CA  1 
ATOM   3143 C C   . GLU B 1 55  ? -105.38096 5.41607   -92.15102  1.000 28.65607 ? 55  GLU B C   1 
ATOM   3144 O O   . GLU B 1 55  ? -105.04893 5.41953   -93.33977  1.000 29.76789 ? 55  GLU B O   1 
ATOM   3145 C CB  . GLU B 1 55  ? -104.69691 7.41294   -90.77758  1.000 31.98615 ? 55  GLU B CB  1 
ATOM   3146 C CG  . GLU B 1 55  ? -103.54632 8.08855   -90.03786  1.000 36.29652 ? 55  GLU B CG  1 
ATOM   3147 C CD  . GLU B 1 55  ? -103.73786 9.58360   -89.84794  1.000 41.32223 ? 55  GLU B CD  1 
ATOM   3148 O OE1 . GLU B 1 55  ? -104.72369 10.13028  -90.39280  1.000 38.92042 ? 55  GLU B OE1 1 
ATOM   3149 O OE2 . GLU B 1 55  ? -102.88812 10.21031  -89.16969  1.000 46.46652 ? 55  GLU B OE2 1 
ATOM   3150 N N   . GLU B 1 56  ? -106.56128 4.95348   -91.72450  1.000 26.81262 ? 56  GLU B N   1 
ATOM   3151 C CA  . GLU B 1 56  ? -107.51655 4.40992   -92.68461  1.000 31.48815 ? 56  GLU B CA  1 
ATOM   3152 C C   . GLU B 1 56  ? -107.79713 5.43707   -93.77382  1.000 28.25957 ? 56  GLU B C   1 
ATOM   3153 O O   . GLU B 1 56  ? -108.17815 6.57640   -93.49039  1.000 23.61424 ? 56  GLU B O   1 
ATOM   3154 C CB  . GLU B 1 56  ? -108.82041 3.99515   -92.00334  1.000 29.98484 ? 56  GLU B CB  1 
ATOM   3155 C CG  . GLU B 1 56  ? -109.81679 3.36100   -92.98012  1.000 30.39804 ? 56  GLU B CG  1 
ATOM   3156 C CD  . GLU B 1 56  ? -110.87057 2.50904   -92.28195  1.000 33.65049 ? 56  GLU B CD  1 
ATOM   3157 O OE1 . GLU B 1 56  ? -111.17590 2.80800   -91.11078  1.000 38.32301 ? 56  GLU B OE1 1 
ATOM   3158 O OE2 . GLU B 1 56  ? -111.37223 1.53270   -92.89400  1.000 32.16579 ? 56  GLU B OE2 1 
ATOM   3159 N N   . GLY B 1 57  ? -107.56386 5.04417   -95.01760  1.000 25.94874 ? 57  GLY B N   1 
ATOM   3160 C CA  . GLY B 1 57  ? -107.82055 5.91855   -96.13204  1.000 25.03907 ? 57  GLY B CA  1 
ATOM   3161 C C   . GLY B 1 57  ? -106.71442 6.88805   -96.44914  1.000 28.51326 ? 57  GLY B C   1 
ATOM   3162 O O   . GLY B 1 57  ? -106.79983 7.57620   -97.47206  1.000 26.73665 ? 57  GLY B O   1 
ATOM   3163 N N   . LYS B 1 58  ? -105.68215 6.97270   -95.61300  1.000 24.48315 ? 58  LYS B N   1 
ATOM   3164 C CA  . LYS B 1 58  ? -104.48983 7.75901   -95.90950  1.000 24.81049 ? 58  LYS B CA  1 
ATOM   3165 C C   . LYS B 1 58  ? -103.41119 6.79906   -96.39247  1.000 32.50974 ? 58  LYS B C   1 
ATOM   3166 O O   . LYS B 1 58  ? -102.85333 6.02980   -95.59613  1.000 27.63032 ? 58  LYS B O   1 
ATOM   3167 C CB  . LYS B 1 58  ? -104.02056 8.53557   -94.68281  1.000 27.55063 ? 58  LYS B CB  1 
ATOM   3168 C CG  . LYS B 1 58  ? -102.91095 9.51380   -94.95719  1.000 28.70299 ? 58  LYS B CG  1 
ATOM   3169 C CD  . LYS B 1 58  ? -102.36721 10.09859  -93.65435  1.000 29.87151 ? 58  LYS B CD  1 
ATOM   3170 C CE  . LYS B 1 58  ? -101.30117 11.13674  -93.97738  1.000 34.45557 ? 58  LYS B CE  1 
ATOM   3171 N NZ  . LYS B 1 58  ? -100.60006 11.63527  -92.77075  1.000 41.10781 ? 58  LYS B NZ  1 
ATOM   3172 N N   . PHE B 1 59  ? -103.13332 6.82858   -97.69432  1.000 22.16970 ? 59  PHE B N   1 
ATOM   3173 C CA  . PHE B 1 59  ? -102.08234 6.01040   -98.28047  1.000 24.51950 ? 59  PHE B CA  1 
ATOM   3174 C C   . PHE B 1 59  ? -100.83269 6.86552   -98.48774  1.000 33.28987 ? 59  PHE B C   1 
ATOM   3175 O O   . PHE B 1 59  ? -100.92920 8.02570   -98.91232  1.000 27.87096 ? 59  PHE B O   1 
ATOM   3176 C CB  . PHE B 1 59  ? -102.56034 5.36843   -99.58628  1.000 19.15550 ? 59  PHE B CB  1 
ATOM   3177 C CG  . PHE B 1 59  ? -103.59175 4.29125   -99.36950  1.000 25.82362 ? 59  PHE B CG  1 
ATOM   3178 C CD1 . PHE B 1 59  ? -103.20339 2.98792   -99.12102  1.000 24.50613 ? 59  PHE B CD1 1 
ATOM   3179 C CD2 . PHE B 1 59  ? -104.95776 4.59637   -99.36322  1.000 21.09213 ? 59  PHE B CD2 1 
ATOM   3180 C CE1 . PHE B 1 59  ? -104.14550 1.99415   -98.89455  1.000 24.70834 ? 59  PHE B CE1 1 
ATOM   3181 C CE2 . PHE B 1 59  ? -105.90650 3.61154   -99.12716  1.000 23.97950 ? 59  PHE B CE2 1 
ATOM   3182 C CZ  . PHE B 1 59  ? -105.50610 2.30823   -98.89150  1.000 27.28599 ? 59  PHE B CZ  1 
ATOM   3183 N N   . THR B 1 60  ? -99.66736  6.30739   -98.14163  1.000 24.80544 ? 60  THR B N   1 
ATOM   3184 C CA  . THR B 1 60  ? -98.37418  7.00557   -98.22368  1.000 26.67868 ? 60  THR B CA  1 
ATOM   3185 C C   . THR B 1 60  ? -97.41169  6.15986   -99.05358  1.000 29.14471 ? 60  THR B C   1 
ATOM   3186 O O   . THR B 1 60  ? -96.56555  5.44533   -98.50504  1.000 26.85896 ? 60  THR B O   1 
ATOM   3187 C CB  . THR B 1 60  ? -97.77711  7.28742   -96.80957  1.000 28.33291 ? 60  THR B CB  1 
ATOM   3188 O OG1 . THR B 1 60  ? -97.59609  6.04541   -96.11527  1.000 26.78992 ? 60  THR B OG1 1 
ATOM   3189 C CG2 . THR B 1 60  ? -98.68802  8.20069   -95.99595  1.000 22.32779 ? 60  THR B CG2 1 
ATOM   3190 N N   . PHE B 1 61  ? -97.52930  6.26176   -100.37892 1.000 28.20084 ? 61  PHE B N   1 
ATOM   3191 C CA  . PHE B 1 61  ? -96.73280  5.46310   -101.29951 1.000 24.36392 ? 61  PHE B CA  1 
ATOM   3192 C C   . PHE B 1 61  ? -95.41613  6.11920   -101.68799 1.000 24.91974 ? 61  PHE B C   1 
ATOM   3193 O O   . PHE B 1 61  ? -94.67166  5.52585   -102.47051 1.000 26.24521 ? 61  PHE B O   1 
ATOM   3194 C CB  . PHE B 1 61  ? -97.51868  5.17297   -102.57853 1.000 24.57570 ? 61  PHE B CB  1 
ATOM   3195 C CG  . PHE B 1 61  ? -98.70653  4.26916   -102.38482 1.000 24.66442 ? 61  PHE B CG  1 
ATOM   3196 C CD1 . PHE B 1 61  ? -98.53627  2.91323   -102.16242 1.000 21.58833 ? 61  PHE B CD1 1 
ATOM   3197 C CD2 . PHE B 1 61  ? -99.99860  4.77524   -102.46212 1.000 23.16289 ? 61  PHE B CD2 1 
ATOM   3198 C CE1 . PHE B 1 61  ? -99.62006  2.07232   -101.98845 1.000 23.30353 ? 61  PHE B CE1 1 
ATOM   3199 C CE2 . PHE B 1 61  ? -101.10249 3.93268   -102.30785 1.000 24.32753 ? 61  PHE B CE2 1 
ATOM   3200 C CZ  . PHE B 1 61  ? -100.91962 2.58320   -102.06430 1.000 21.64211 ? 61  PHE B CZ  1 
ATOM   3201 N N   . GLN B 1 62  ? -95.12133  7.32251   -101.18014 1.000 20.86253 ? 62  GLN B N   1 
ATOM   3202 C CA  . GLN B 1 62  ? -93.97723  8.09451   -101.67354 1.000 25.86383 ? 62  GLN B CA  1 
ATOM   3203 C C   . GLN B 1 62  ? -92.68166  7.29708   -101.58656 1.000 24.85284 ? 62  GLN B C   1 
ATOM   3204 O O   . GLN B 1 62  ? -91.94826  7.18488   -102.57214 1.000 26.54764 ? 62  GLN B O   1 
ATOM   3205 C CB  . GLN B 1 62  ? -93.82978  9.40182   -100.89561 1.000 26.91251 ? 62  GLN B CB  1 
ATOM   3206 C CG  . GLN B 1 62  ? -95.03295  10.34821  -100.95788 1.000 28.80721 ? 62  GLN B CG  1 
ATOM   3207 C CD  . GLN B 1 62  ? -95.87258  10.26755  -99.69453  1.000 30.29110 ? 62  GLN B CD  1 
ATOM   3208 O OE1 . GLN B 1 62  ? -96.36898  9.19468   -99.33530  1.000 27.79826 ? 62  GLN B OE1 1 
ATOM   3209 N NE2 . GLN B 1 62  ? -96.00802  11.39109  -98.99470  1.000 26.84656 ? 62  GLN B NE2 1 
ATOM   3210 N N   . GLU B 1 63  ? -92.39178  6.72200   -100.41859 1.000 22.09341 ? 63  GLU B N   1 
ATOM   3211 C CA  . GLU B 1 63  ? -91.12976  6.00858   -100.24214 1.000 27.76708 ? 63  GLU B CA  1 
ATOM   3212 C C   . GLU B 1 63  ? -91.09193  4.72527   -101.06727 1.000 24.67035 ? 63  GLU B C   1 
ATOM   3213 O O   . GLU B 1 63  ? -90.10272  4.46163   -101.76306 1.000 31.85342 ? 63  GLU B O   1 
ATOM   3214 C CB  . GLU B 1 63  ? -90.88345  5.72807   -98.75395  1.000 26.74627 ? 63  GLU B CB  1 
ATOM   3215 C CG  . GLU B 1 63  ? -90.94233  6.98504   -97.88156  1.000 30.96215 ? 63  GLU B CG  1 
ATOM   3216 C CD  . GLU B 1 63  ? -89.66309  7.81843   -97.97032  1.000 59.33652 ? 63  GLU B CD  1 
ATOM   3217 O OE1 . GLU B 1 63  ? -89.26809  8.22542   -99.09078  1.000 58.66652 ? 63  GLU B OE1 1 
ATOM   3218 O OE2 . GLU B 1 63  ? -89.03860  8.06312   -96.91218  1.000 58.78932 ? 63  GLU B OE2 1 
ATOM   3219 N N   . ALA B 1 64  ? -92.16307  3.91893   -101.01929 1.000 20.79248 ? 64  ALA B N   1 
ATOM   3220 C CA  . ALA B 1 64  ? -92.21509  2.71490   -101.85453 1.000 21.52665 ? 64  ALA B CA  1 
ATOM   3221 C C   . ALA B 1 64  ? -92.09509  3.04852   -103.33869 1.000 24.53636 ? 64  ALA B C   1 
ATOM   3222 O O   . ALA B 1 64  ? -91.45482  2.30473   -104.09090 1.000 30.05548 ? 64  ALA B O   1 
ATOM   3223 C CB  . ALA B 1 64  ? -93.50605  1.92209   -101.60413 1.000 18.59952 ? 64  ALA B CB  1 
ATOM   3224 N N   . ASP B 1 65  ? -92.72066  4.14811   -103.78542 1.000 20.37945 ? 65  ASP B N   1 
ATOM   3225 C CA  . ASP B 1 65  ? -92.61555  4.54657   -105.19254 1.000 25.63255 ? 65  ASP B CA  1 
ATOM   3226 C C   . ASP B 1 65  ? -91.16113  4.76934   -105.59766 1.000 30.74930 ? 65  ASP B C   1 
ATOM   3227 O O   . ASP B 1 65  ? -90.73470  4.34672   -106.67973 1.000 29.01530 ? 65  ASP B O   1 
ATOM   3228 C CB  . ASP B 1 65  ? -93.40742  5.83017   -105.46770 1.000 24.32306 ? 65  ASP B CB  1 
ATOM   3229 C CG  . ASP B 1 65  ? -94.92244  5.62581   -105.48307 1.000 33.76652 ? 65  ASP B CG  1 
ATOM   3230 O OD1 . ASP B 1 65  ? -95.42208  4.47104   -105.56222 1.000 23.03376 ? 65  ASP B OD1 1 
ATOM   3231 O OD2 . ASP B 1 65  ? -95.61443  6.66826   -105.45510 1.000 27.29121 ? 65  ASP B OD2 1 
ATOM   3232 N N   . ARG B 1 66  ? -90.39979  5.47987   -104.75156 1.000 23.59363 ? 66  ARG B N   1 
ATOM   3233 C CA  . ARG B 1 66  ? -88.98637  5.72607   -105.01313 1.000 29.73803 ? 66  ARG B CA  1 
ATOM   3234 C C   . ARG B 1 66  ? -88.21091  4.42163   -105.09230 1.000 28.71064 ? 66  ARG B C   1 
ATOM   3235 O O   . ARG B 1 66  ? -87.37010  4.24647   -105.97778 1.000 27.52299 ? 66  ARG B O   1 
ATOM   3236 C CB  . ARG B 1 66  ? -88.39810  6.62967   -103.92785 1.000 26.39966 ? 66  ARG B CB  1 
ATOM   3237 C CG  . ARG B 1 66  ? -86.89476  7.00555   -104.13983 1.000 58.69329 ? 66  ARG B CG  1 
ATOM   3238 C CD  . ARG B 1 66  ? -86.41402  7.13552   -105.63415 1.000 57.51566 ? 66  ARG B CD  1 
ATOM   3239 N NE  . ARG B 1 66  ? -84.94549  7.23072   -105.73061 1.000 69.40128 ? 66  ARG B NE  1 
ATOM   3240 C CZ  . ARG B 1 66  ? -84.22009  6.96710   -106.82734 1.000 73.04584 ? 66  ARG B CZ  1 
ATOM   3241 N NH1 . ARG B 1 66  ? -84.81448  6.58502   -107.96047 1.000 59.13304 ? 66  ARG B NH1 1 
ATOM   3242 N NH2 . ARG B 1 66  ? -82.88800  7.08191   -106.79530 1.000 55.40760 ? 66  ARG B NH2 1 
ATOM   3243 N N   . ILE B 1 67  ? -88.49422  3.48849   -104.18423 1.000 28.39127 ? 67  ILE B N   1 
ATOM   3244 C CA  . ILE B 1 67  ? -87.83828  2.18305   -104.22826 1.000 21.20087 ? 67  ILE B CA  1 
ATOM   3245 C C   . ILE B 1 67  ? -88.16782  1.46070   -105.52677 1.000 27.80993 ? 67  ILE B C   1 
ATOM   3246 O O   . ILE B 1 67  ? -87.27868  0.89970   -106.18356 1.000 26.95953 ? 67  ILE B O   1 
ATOM   3247 C CB  . ILE B 1 67  ? -88.23846  1.34848   -102.99502 1.000 22.66326 ? 67  ILE B CB  1 
ATOM   3248 C CG1 . ILE B 1 67  ? -87.67833  1.97853   -101.70882 1.000 18.98616 ? 67  ILE B CG1 1 
ATOM   3249 C CG2 . ILE B 1 67  ? -87.84301  -0.11446  -103.18691 1.000 18.89590 ? 67  ILE B CG2 1 
ATOM   3250 C CD1 . ILE B 1 67  ? -88.20653  1.36085   -100.45130 1.000 19.86119 ? 67  ILE B CD1 1 
ATOM   3251 N N   . VAL B 1 68  ? -89.44807  1.47258   -105.92212 1.000 25.13459 ? 68  VAL B N   1 
ATOM   3252 C CA  . VAL B 1 68  ? -89.86824  0.80624   -107.15295 1.000 20.92908 ? 68  VAL B CA  1 
ATOM   3253 C C   . VAL B 1 68  ? -89.31382  1.52395   -108.38217 1.000 26.22647 ? 68  VAL B C   1 
ATOM   3254 O O   . VAL B 1 68  ? -88.86862  0.88109   -109.33969 1.000 26.01112 ? 68  VAL B O   1 
ATOM   3255 C CB  . VAL B 1 68  ? -91.40286  0.69412   -107.21181 1.000 23.91705 ? 68  VAL B CB  1 
ATOM   3256 C CG1 . VAL B 1 68  ? -91.83969  0.22346   -108.59001 1.000 23.59459 ? 68  VAL B CG1 1 
ATOM   3257 C CG2 . VAL B 1 68  ? -91.88753  -0.29307  -106.18502 1.000 21.64490 ? 68  VAL B CG2 1 
ATOM   3258 N N   . ASP B 1 69  ? -89.33567  2.85891   -108.38650 1.000 23.38264 ? 69  ASP B N   1 
ATOM   3259 C CA  . ASP B 1 69  ? -88.80806  3.58610   -109.53698 1.000 23.36269 ? 69  ASP B CA  1 
ATOM   3260 C C   . ASP B 1 69  ? -87.32510  3.29279   -109.73618 1.000 34.97911 ? 69  ASP B C   1 
ATOM   3261 O O   . ASP B 1 69  ? -86.88942  3.00054   -110.86053 1.000 30.31259 ? 69  ASP B O   1 
ATOM   3262 C CB  . ASP B 1 69  ? -89.04683  5.09394   -109.38244 1.000 35.44415 ? 69  ASP B CB  1 
ATOM   3263 C CG  . ASP B 1 69  ? -90.54231  5.48566   -109.47534 1.000 54.20652 ? 69  ASP B CG  1 
ATOM   3264 O OD1 . ASP B 1 69  ? -91.37342  4.67197   -109.95556 1.000 42.45123 ? 69  ASP B OD1 1 
ATOM   3265 O OD2 . ASP B 1 69  ? -90.88148  6.63269   -109.09133 1.000 53.27652 ? 69  ASP B OD2 1 
ATOM   3266 N N   . PHE B 1 70  ? -86.53856  3.34869   -108.65041 1.000 34.08785 ? 70  PHE B N   1 
ATOM   3267 C CA  . PHE B 1 70  ? -85.12336  2.98310   -108.71292 1.000 30.51065 ? 70  PHE B CA  1 
ATOM   3268 C C   . PHE B 1 70  ? -84.93213  1.61496   -109.35679 1.000 29.15638 ? 70  PHE B C   1 
ATOM   3269 O O   . PHE B 1 70  ? -84.13396  1.45659   -110.28810 1.000 33.43266 ? 70  PHE B O   1 
ATOM   3270 C CB  . PHE B 1 70  ? -84.50987  2.99209   -107.31082 1.000 29.74913 ? 70  PHE B CB  1 
ATOM   3271 C CG  . PHE B 1 70  ? -83.11140  2.45849   -107.27181 1.000 33.14451 ? 70  PHE B CG  1 
ATOM   3272 C CD1 . PHE B 1 70  ? -82.05551  3.22839   -107.72579 1.000 32.53811 ? 70  PHE B CD1 1 
ATOM   3273 C CD2 . PHE B 1 70  ? -82.85504  1.17747   -106.82655 1.000 27.14317 ? 70  PHE B CD2 1 
ATOM   3274 C CE1 . PHE B 1 70  ? -80.77149  2.74172   -107.71711 1.000 27.53740 ? 70  PHE B CE1 1 
ATOM   3275 C CE2 . PHE B 1 70  ? -81.55426  0.68341   -106.81014 1.000 30.18852 ? 70  PHE B CE2 1 
ATOM   3276 C CZ  . PHE B 1 70  ? -80.52249  1.46499   -107.25114 1.000 28.11109 ? 70  PHE B CZ  1 
ATOM   3277 N N   . ALA B 1 71  ? -85.67770  0.61740   -108.88149 1.000 27.94266 ? 71  ALA B N   1 
ATOM   3278 C CA  . ALA B 1 71  ? -85.52129  -0.74132  -109.38932 1.000 33.73451 ? 71  ALA B CA  1 
ATOM   3279 C C   . ALA B 1 71  ? -85.81890  -0.82048  -110.88180 1.000 30.37311 ? 71  ALA B C   1 
ATOM   3280 O O   . ALA B 1 71  ? -85.02162  -1.35972  -111.65294 1.000 31.84500 ? 71  ALA B O   1 
ATOM   3281 C CB  . ALA B 1 71  ? -86.43405  -1.68709  -108.62095 1.000 22.28724 ? 71  ALA B CB  1 
ATOM   3282 N N   . CYS B 1 72  ? -86.98208  -0.30749  -111.30167 1.000 30.20714 ? 72  CYS B N   1 
ATOM   3283 C CA  . CYS B 1 72  ? -87.35446  -0.34168  -112.71574 1.000 37.31113 ? 72  CYS B CA  1 
ATOM   3284 C C   . CYS B 1 72  ? -86.34506  0.39801   -113.58111 1.000 35.17893 ? 72  CYS B C   1 
ATOM   3285 O O   . CYS B 1 72  ? -86.07549  -0.00443  -114.71719 1.000 32.48516 ? 72  CYS B O   1 
ATOM   3286 C CB  . CYS B 1 72  ? -88.74685  0.26110   -112.92212 1.000 33.28797 ? 72  CYS B CB  1 
ATOM   3287 S SG  . CYS B 1 72  ? -90.05546  -0.71539  -112.19065 1.000 38.33056 ? 72  CYS B SG  1 
ATOM   3288 N N   . SER B 1 73  ? -85.79758  1.50075   -113.06926 1.000 33.31095 ? 73  SER B N   1 
ATOM   3289 C CA  . SER B 1 73  ? -84.80656  2.25221   -113.82110 1.000 33.47772 ? 73  SER B CA  1 
ATOM   3290 C C   . SER B 1 73  ? -83.53211  1.47392   -114.07853 1.000 40.15216 ? 73  SER B C   1 
ATOM   3291 O O   . SER B 1 73  ? -82.73487  1.89449   -114.92176 1.000 41.23336 ? 73  SER B O   1 
ATOM   3292 C CB  . SER B 1 73  ? -84.43250  3.51579   -113.04359 1.000 33.26877 ? 73  SER B CB  1 
ATOM   3293 O OG  . SER B 1 73  ? -85.53562  4.38240   -113.00118 1.000 51.71588 ? 73  SER B OG  1 
ATOM   3294 N N   . HIS B 1 74  ? -83.28994  0.39678   -113.32826 1.000 36.55461 ? 74  HIS B N   1 
ATOM   3295 C CA  . HIS B 1 74  ? -82.04692  -0.35461  -113.41748 1.000 34.40115 ? 74  HIS B CA  1 
ATOM   3296 C C   . HIS B 1 74  ? -82.30088  -1.83427  -113.65164 1.000 32.53869 ? 74  HIS B C   1 
ATOM   3297 O O   . HIS B 1 74  ? -81.47036  -2.65991  -113.28461 1.000 39.94607 ? 74  HIS B O   1 
ATOM   3298 C CB  . HIS B 1 74  ? -81.19271  -0.16346  -112.16217 1.000 26.12116 ? 74  HIS B CB  1 
ATOM   3299 C CG  . HIS B 1 74  ? -80.73551  1.24491   -111.95587 1.000 30.29734 ? 74  HIS B CG  1 
ATOM   3300 N ND1 . HIS B 1 74  ? -81.36811  2.11162   -111.08805 1.000 35.01774 ? 74  HIS B ND1 1 
ATOM   3301 C CD2 . HIS B 1 74  ? -79.71388  1.94434   -112.50368 1.000 37.16236 ? 74  HIS B CD2 1 
ATOM   3302 C CE1 . HIS B 1 74  ? -80.75698  3.28338   -111.11048 1.000 36.82016 ? 74  HIS B CE1 1 
ATOM   3303 N NE2 . HIS B 1 74  ? -79.74785  3.20887   -111.95904 1.000 37.08840 ? 74  HIS B NE2 1 
ATOM   3304 N N   . ARG B 1 75  ? -83.44705  -2.17333  -114.24614 1.000 33.35556 ? 75  ARG B N   1 
ATOM   3305 C CA  . ARG B 1 75  ? -83.82253  -3.54058  -114.62275 1.000 38.31951 ? 75  ARG B CA  1 
ATOM   3306 C C   . ARG B 1 75  ? -83.67649  -4.49923  -113.44132 1.000 41.98316 ? 75  ARG B C   1 
ATOM   3307 O O   . ARG B 1 75  ? -83.16261  -5.61380  -113.57034 1.000 45.36819 ? 75  ARG B O   1 
ATOM   3308 C CB  . ARG B 1 75  ? -83.03003  -4.02193  -115.85738 1.000 58.88569 ? 75  ARG B CB  1 
ATOM   3309 C CG  . ARG B 1 75  ? -81.51836  -4.31492  -115.61139 1.000 64.83389 ? 75  ARG B CG  1 
ATOM   3310 C CD  . ARG B 1 75  ? -80.81758  -5.09359  -116.73224 1.000 63.22821 ? 75  ARG B CD  1 
ATOM   3311 N NE  . ARG B 1 75  ? -79.53072  -4.49394  -117.10365 1.000 62.05834 ? 75  ARG B NE  1 
ATOM   3312 C CZ  . ARG B 1 75  ? -78.46681  -4.50855  -116.30765 1.000 59.61960 ? 75  ARG B CZ  1 
ATOM   3313 N NH1 . ARG B 1 75  ? -78.56769  -5.07074  -115.10381 1.000 46.73069 ? 75  ARG B NH1 1 
ATOM   3314 N NH2 . ARG B 1 75  ? -77.31538  -3.94776  -116.70128 1.000 54.21530 ? 75  ARG B NH2 1 
ATOM   3315 N N   . MET B 1 76  ? -84.15990  -4.06239  -112.27446 1.000 35.75317 ? 76  MET B N   1 
ATOM   3316 C CA  . MET B 1 76  ? -84.25355  -4.90139  -111.08915 1.000 31.87699 ? 76  MET B CA  1 
ATOM   3317 C C   . MET B 1 76  ? -85.70711  -5.31395  -110.87567 1.000 22.89950 ? 76  MET B C   1 
ATOM   3318 O O   . MET B 1 76  ? -86.60784  -4.47686  -110.98482 1.000 34.41647 ? 76  MET B O   1 
ATOM   3319 C CB  . MET B 1 76  ? -83.72050  -4.15638  -109.86225 1.000 28.31977 ? 76  MET B CB  1 
ATOM   3320 C CG  . MET B 1 76  ? -82.25852  -3.72838  -109.98281 1.000 27.83278 ? 76  MET B CG  1 
ATOM   3321 S SD  . MET B 1 76  ? -81.70371  -2.47932  -108.79080 1.000 28.27051 ? 76  MET B SD  1 
ATOM   3322 C CE  . MET B 1 76  ? -80.00885  -2.17822  -109.35713 1.000 26.96310 ? 76  MET B CE  1 
ATOM   3323 N N   . ALA B 1 77  ? -85.93170  -6.59652  -110.58267 1.000 21.21649 ? 77  ALA B N   1 
ATOM   3324 C CA  . ALA B 1 77  ? -87.21179  -7.03711  -110.05767 1.000 25.70241 ? 77  ALA B CA  1 
ATOM   3325 C C   . ALA B 1 77  ? -87.41219  -6.46353  -108.65723 1.000 29.75149 ? 77  ALA B C   1 
ATOM   3326 O O   . ALA B 1 77  ? -86.47439  -5.95825  -108.03340 1.000 26.07462 ? 77  ALA B O   1 
ATOM   3327 C CB  . ALA B 1 77  ? -87.28657  -8.56256  -110.01180 1.000 20.75531 ? 77  ALA B CB  1 
ATOM   3328 N N   . VAL B 1 78  ? -88.65758  -6.52569  -108.17015 1.000 20.58653 ? 78  VAL B N   1 
ATOM   3329 C CA  . VAL B 1 78  ? -89.00602  -6.07614  -106.82382 1.000 21.37594 ? 78  VAL B CA  1 
ATOM   3330 C C   . VAL B 1 78  ? -89.87707  -7.12942  -106.16155 1.000 22.54739 ? 78  VAL B C   1 
ATOM   3331 O O   . VAL B 1 78  ? -90.88415  -7.55443  -106.73967 1.000 23.07138 ? 78  VAL B O   1 
ATOM   3332 C CB  . VAL B 1 78  ? -89.74592  -4.72686  -106.81985 1.000 19.63618 ? 78  VAL B CB  1 
ATOM   3333 C CG1 . VAL B 1 78  ? -90.05316  -4.28825  -105.37308 1.000 20.22418 ? 78  VAL B CG1 1 
ATOM   3334 C CG2 . VAL B 1 78  ? -88.95569  -3.66476  -107.55316 1.000 22.39417 ? 78  VAL B CG2 1 
ATOM   3335 N N   . ARG B 1 79  ? -89.49920  -7.53219  -104.94473 1.000 20.85297 ? 79  ARG B N   1 
ATOM   3336 C CA  . ARG B 1 79  ? -90.32394  -8.36522  -104.07813 1.000 21.78066 ? 79  ARG B CA  1 
ATOM   3337 C C   . ARG B 1 79  ? -91.10596  -7.45802  -103.14189 1.000 26.84650 ? 79  ARG B C   1 
ATOM   3338 O O   . ARG B 1 79  ? -90.51373  -6.60124  -102.47365 1.000 22.97222 ? 79  ARG B O   1 
ATOM   3339 C CB  . ARG B 1 79  ? -89.48068  -9.33164  -103.24143 1.000 19.69338 ? 79  ARG B CB  1 
ATOM   3340 C CG  . ARG B 1 79  ? -88.51014  -10.20575 -103.99683 1.000 23.61285 ? 79  ARG B CG  1 
ATOM   3341 C CD  . ARG B 1 79  ? -87.89278  -11.27052 -103.05828 1.000 26.96610 ? 79  ARG B CD  1 
ATOM   3342 N NE  . ARG B 1 79  ? -88.83336  -12.35343 -102.77610 1.000 16.85013 ? 79  ARG B NE  1 
ATOM   3343 C CZ  . ARG B 1 79  ? -89.56691  -12.46263 -101.67307 1.000 22.53991 ? 79  ARG B CZ  1 
ATOM   3344 N NH1 . ARG B 1 79  ? -89.45683  -11.56354 -100.70070 1.000 19.60039 ? 79  ARG B NH1 1 
ATOM   3345 N NH2 . ARG B 1 79  ? -90.40938  -13.49259 -101.53548 1.000 22.92591 ? 79  ARG B NH2 1 
ATOM   3346 N N   . GLY B 1 80  ? -92.42125  -7.66468  -103.06640 1.000 21.41419 ? 80  GLY B N   1 
ATOM   3347 C CA  . GLY B 1 80  ? -93.23121  -6.90808  -102.12675 1.000 16.99805 ? 80  GLY B CA  1 
ATOM   3348 C C   . GLY B 1 80  ? -93.18056  -7.48659  -100.71182 1.000 17.14021 ? 80  GLY B C   1 
ATOM   3349 O O   . GLY B 1 80  ? -93.47817  -8.66444  -100.49548 1.000 19.60139 ? 80  GLY B O   1 
ATOM   3350 N N   . HIS B 1 81  ? -92.85624  -6.63795  -99.73848  1.000 22.60406 ? 81  HIS B N   1 
ATOM   3351 C CA  . HIS B 1 81  ? -92.76183  -7.04776  -98.33749  1.000 20.22789 ? 81  HIS B CA  1 
ATOM   3352 C C   . HIS B 1 81  ? -93.30374  -5.92164  -97.46088  1.000 18.15755 ? 81  HIS B C   1 
ATOM   3353 O O   . HIS B 1 81  ? -92.71064  -4.83932  -97.42378  1.000 20.17031 ? 81  HIS B O   1 
ATOM   3354 C CB  . HIS B 1 81  ? -91.29341  -7.36018  -98.00514  1.000 20.00786 ? 81  HIS B CB  1 
ATOM   3355 C CG  . HIS B 1 81  ? -91.04473  -7.78637  -96.59357  1.000 23.09990 ? 81  HIS B CG  1 
ATOM   3356 N ND1 . HIS B 1 81  ? -91.22343  -9.08616  -96.16757  1.000 20.34255 ? 81  HIS B ND1 1 
ATOM   3357 C CD2 . HIS B 1 81  ? -90.57200  -7.10046  -95.52584  1.000 19.99750 ? 81  HIS B CD2 1 
ATOM   3358 C CE1 . HIS B 1 81  ? -90.91120  -9.17224  -94.88760  1.000 20.45121 ? 81  HIS B CE1 1 
ATOM   3359 N NE2 . HIS B 1 81  ? -90.50305  -7.98267  -94.47689  1.000 24.25019 ? 81  HIS B NE2 1 
ATOM   3360 N N   . THR B 1 82  ? -94.41176  -6.14879  -96.74813  1.000 20.16567 ? 82  THR B N   1 
ATOM   3361 C CA  . THR B 1 82  ? -95.18952  -7.39441  -96.69099  1.000 19.50226 ? 82  THR B CA  1 
ATOM   3362 C C   . THR B 1 82  ? -96.63693  -6.99479  -96.35459  1.000 22.62022 ? 82  THR B C   1 
ATOM   3363 O O   . THR B 1 82  ? -96.84700  -5.92940  -95.77812  1.000 21.70932 ? 82  THR B O   1 
ATOM   3364 C CB  . THR B 1 82  ? -94.63011  -8.37873  -95.63549  1.000 17.11026 ? 82  THR B CB  1 
ATOM   3365 O OG1 . THR B 1 82  ? -95.52823  -9.47037  -95.45582  1.000 21.89410 ? 82  THR B OG1 1 
ATOM   3366 C CG2 . THR B 1 82  ? -94.41055  -7.68296  -94.28458  1.000 15.00674 ? 82  THR B CG2 1 
ATOM   3367 N N   . LEU B 1 83  ? -97.63184  -7.82325  -96.69585  1.000 23.42393 ? 83  LEU B N   1 
ATOM   3368 C CA  . LEU B 1 83  ? -99.03567  -7.39934  -96.59789  1.000 18.32504 ? 83  LEU B CA  1 
ATOM   3369 C C   . LEU B 1 83  ? -99.62229  -7.60560  -95.20415  1.000 23.26880 ? 83  LEU B C   1 
ATOM   3370 O O   . LEU B 1 83  ? -100.06740 -6.64207  -94.56808  1.000 17.95127 ? 83  LEU B O   1 
ATOM   3371 C CB  . LEU B 1 83  ? -99.90167  -8.13207  -97.63638  1.000 18.89445 ? 83  LEU B CB  1 
ATOM   3372 C CG  . LEU B 1 83  ? -99.51248  -7.81464  -99.08124  1.000 20.34915 ? 83  LEU B CG  1 
ATOM   3373 C CD1 . LEU B 1 83  ? -100.30461 -8.64725  -100.05451 1.000 17.79654 ? 83  LEU B CD1 1 
ATOM   3374 C CD2 . LEU B 1 83  ? -99.65004  -6.31848  -99.34996  1.000 14.06996 ? 83  LEU B CD2 1 
ATOM   3375 N N   . VAL B 1 84  ? -99.66551  -8.85258  -94.73138  1.000 16.16095 ? 84  VAL B N   1 
ATOM   3376 C CA  . VAL B 1 84  ? -100.31214 -9.18664  -93.46401  1.000 24.78173 ? 84  VAL B CA  1 
ATOM   3377 C C   . VAL B 1 84  ? -99.26146  -9.75994  -92.51503  1.000 27.82420 ? 84  VAL B C   1 
ATOM   3378 O O   . VAL B 1 84  ? -98.68703  -10.82420 -92.78193  1.000 25.77186 ? 84  VAL B O   1 
ATOM   3379 C CB  . VAL B 1 84  ? -101.49461 -10.14677 -93.66955  1.000 25.85577 ? 84  VAL B CB  1 
ATOM   3380 C CG1 . VAL B 1 84  ? -102.15259 -10.49699 -92.33106  1.000 20.89801 ? 84  VAL B CG1 1 
ATOM   3381 C CG2 . VAL B 1 84  ? -102.54006 -9.48786  -94.60895  1.000 16.90770 ? 84  VAL B CG2 1 
ATOM   3382 N N   . TRP B 1 85  ? -99.01310  -9.04259  -91.41321  1.000 25.12799 ? 85  TRP B N   1 
ATOM   3383 C CA  . TRP B 1 85  ? -97.95966  -9.33309  -90.44522  1.000 25.90024 ? 85  TRP B CA  1 
ATOM   3384 C C   . TRP B 1 85  ? -98.41052  -8.80582  -89.09016  1.000 24.19442 ? 85  TRP B C   1 
ATOM   3385 O O   . TRP B 1 85  ? -98.99060  -7.71948  -89.01864  1.000 25.89615 ? 85  TRP B O   1 
ATOM   3386 C CB  . TRP B 1 85  ? -96.63819  -8.65418  -90.85828  1.000 21.85114 ? 85  TRP B CB  1 
ATOM   3387 C CG  . TRP B 1 85  ? -95.41160  -9.01913  -90.06651  1.000 24.94439 ? 85  TRP B CG  1 
ATOM   3388 C CD1 . TRP B 1 85  ? -95.15536  -10.20170 -89.43217  1.000 22.07678 ? 85  TRP B CD1 1 
ATOM   3389 C CD2 . TRP B 1 85  ? -94.24500  -8.19953  -89.87393  1.000 25.27053 ? 85  TRP B CD2 1 
ATOM   3390 N NE1 . TRP B 1 85  ? -93.90809  -10.16611 -88.85842  1.000 26.32890 ? 85  TRP B NE1 1 
ATOM   3391 C CE2 . TRP B 1 85  ? -93.33152  -8.94917  -89.10702  1.000 25.96959 ? 85  TRP B CE2 1 
ATOM   3392 C CE3 . TRP B 1 85  ? -93.89389  -6.90114  -90.26923  1.000 22.18474 ? 85  TRP B CE3 1 
ATOM   3393 C CZ2 . TRP B 1 85  ? -92.08685  -8.44942  -88.72570  1.000 27.11744 ? 85  TRP B CZ2 1 
ATOM   3394 C CZ3 . TRP B 1 85  ? -92.66454  -6.40390  -89.89126  1.000 29.11881 ? 85  TRP B CZ3 1 
ATOM   3395 C CH2 . TRP B 1 85  ? -91.76658  -7.18328  -89.13299  1.000 20.96477 ? 85  TRP B CH2 1 
ATOM   3396 N N   . HIS B 1 86  ? -98.14084  -9.56244  -88.01824  1.000 26.51636 ? 86  HIS B N   1 
ATOM   3397 C CA  . HIS B 1 86  ? -98.49479  -9.08173  -86.68115  1.000 26.67726 ? 86  HIS B CA  1 
ATOM   3398 C C   . HIS B 1 86  ? -97.71757  -7.82078  -86.29812  1.000 25.80801 ? 86  HIS B C   1 
ATOM   3399 O O   . HIS B 1 86  ? -98.18264  -7.03656  -85.46215  1.000 26.37558 ? 86  HIS B O   1 
ATOM   3400 C CB  . HIS B 1 86  ? -98.25622  -10.17766 -85.64008  1.000 26.88867 ? 86  HIS B CB  1 
ATOM   3401 C CG  . HIS B 1 86  ? -96.84958  -10.69020 -85.62911  1.000 30.45587 ? 86  HIS B CG  1 
ATOM   3402 N ND1 . HIS B 1 86  ? -96.45755  -11.79841 -86.34733  1.000 30.48715 ? 86  HIS B ND1 1 
ATOM   3403 C CD2 . HIS B 1 86  ? -95.73469  -10.22356 -85.01699  1.000 27.39973 ? 86  HIS B CD2 1 
ATOM   3404 C CE1 . HIS B 1 86  ? -95.16446  -11.99931 -86.16898  1.000 29.95429 ? 86  HIS B CE1 1 
ATOM   3405 N NE2 . HIS B 1 86  ? -94.70162  -11.05153 -85.37427  1.000 27.68505 ? 86  HIS B NE2 1 
ATOM   3406 N N   . ASN B 1 87  ? -96.54901  -7.59613  -86.89352  1.000 23.38683 ? 87  ASN B N   1 
ATOM   3407 C CA  . ASN B 1 87  ? -95.76790  -6.40458  -86.58840  1.000 25.93746 ? 87  ASN B CA  1 
ATOM   3408 C C   . ASN B 1 87  ? -96.06728  -5.25700  -87.54855  1.000 24.16002 ? 87  ASN B C   1 
ATOM   3409 O O   . ASN B 1 87  ? -96.62844  -5.44123  -88.63017  1.000 27.73919 ? 87  ASN B O   1 
ATOM   3410 C CB  . ASN B 1 87  ? -94.26749  -6.70167  -86.63298  1.000 27.74691 ? 87  ASN B CB  1 
ATOM   3411 C CG  . ASN B 1 87  ? -93.76523  -7.27064  -85.33756  1.000 36.46030 ? 87  ASN B CG  1 
ATOM   3412 O OD1 . ASN B 1 87  ? -94.49552  -7.28780  -84.34775  1.000 33.81255 ? 87  ASN B OD1 1 
ATOM   3413 N ND2 . ASN B 1 87  ? -92.51565  -7.73849  -85.32419  1.000 31.66631 ? 87  ASN B ND2 1 
ATOM   3414 N N   . GLN B 1 88  ? -95.65096  -4.06146  -87.12897  1.000 26.79747 ? 88  GLN B N   1 
ATOM   3415 C CA  . GLN B 1 88  ? -95.66138  -2.84692  -87.94739  1.000 25.58163 ? 88  GLN B CA  1 
ATOM   3416 C C   . GLN B 1 88  ? -97.00258  -2.67402  -88.66615  1.000 32.33842 ? 88  GLN B C   1 
ATOM   3417 O O   . GLN B 1 88  ? -97.06971  -2.33712  -89.85366  1.000 25.68854 ? 88  GLN B O   1 
ATOM   3418 C CB  . GLN B 1 88  ? -94.46397  -2.82844  -88.91164  1.000 20.45487 ? 88  GLN B CB  1 
ATOM   3419 C CG  . GLN B 1 88  ? -93.09818  -2.73024  -88.17046  1.000 25.04570 ? 88  GLN B CG  1 
ATOM   3420 C CD  . GLN B 1 88  ? -91.87258  -2.62579  -89.08847  1.000 29.43457 ? 88  GLN B CD  1 
ATOM   3421 O OE1 . GLN B 1 88  ? -91.16647  -3.61454  -89.32825  1.000 31.18542 ? 88  GLN B OE1 1 
ATOM   3422 N NE2 . GLN B 1 88  ? -91.61687  -1.42083  -89.60393  1.000 22.11033 ? 88  GLN B NE2 1 
ATOM   3423 N N   . THR B 1 89  ? -98.07959  -2.90501  -87.91434  1.000 26.36880 ? 89  THR B N   1 
ATOM   3424 C CA  . THR B 1 89  ? -99.45454  -2.70255  -88.34832  1.000 27.10119 ? 89  THR B CA  1 
ATOM   3425 C C   . THR B 1 89  ? -100.11921 -1.74279  -87.37514  1.000 28.15186 ? 89  THR B C   1 
ATOM   3426 O O   . THR B 1 89  ? -100.16712 -2.03402  -86.16798  1.000 34.04328 ? 89  THR B O   1 
ATOM   3427 C CB  . THR B 1 89  ? -100.22045 -4.02617  -88.39441  1.000 28.22147 ? 89  THR B CB  1 
ATOM   3428 O OG1 . THR B 1 89  ? -99.57908  -4.90155  -89.32608  1.000 27.97569 ? 89  THR B OG1 1 
ATOM   3429 C CG2 . THR B 1 89  ? -101.65562 -3.79891  -88.83713  1.000 27.33507 ? 89  THR B CG2 1 
ATOM   3430 N N   . PRO B 1 90  ? -100.64320 -0.61152  -87.83268  1.000 25.63481 ? 90  PRO B N   1 
ATOM   3431 C CA  . PRO B 1 90  ? -101.18767 0.38255   -86.90444  1.000 30.20348 ? 90  PRO B CA  1 
ATOM   3432 C C   . PRO B 1 90  ? -102.40360 -0.13277  -86.14196  1.000 33.07948 ? 90  PRO B C   1 
ATOM   3433 O O   . PRO B 1 90  ? -103.08178 -1.08381  -86.54229  1.000 29.98685 ? 90  PRO B O   1 
ATOM   3434 C CB  . PRO B 1 90  ? -101.56076 1.55313   -87.82393  1.000 33.06025 ? 90  PRO B CB  1 
ATOM   3435 C CG  . PRO B 1 90  ? -100.93370 1.24118   -89.13561  1.000 30.78044 ? 90  PRO B CG  1 
ATOM   3436 C CD  . PRO B 1 90  ? -100.85976 -0.22281  -89.22962  1.000 27.00194 ? 90  PRO B CD  1 
ATOM   3437 N N   . ASP B 1 91  ? -102.68018 0.52965   -85.01641  1.000 30.18452 ? 91  ASP B N   1 
ATOM   3438 C CA  . ASP B 1 91  ? -103.75647 0.06724   -84.14086  1.000 33.64817 ? 91  ASP B CA  1 
ATOM   3439 C C   . ASP B 1 91  ? -105.12623 0.24854   -84.77311  1.000 35.07772 ? 91  ASP B C   1 
ATOM   3440 O O   . ASP B 1 91  ? -106.04286 -0.52664  -84.47596  1.000 32.13118 ? 91  ASP B O   1 
ATOM   3441 C CB  . ASP B 1 91  ? -103.71678 0.81128   -82.80758  1.000 35.94828 ? 91  ASP B CB  1 
ATOM   3442 C CG  . ASP B 1 91  ? -102.51318 0.43240   -81.94869  1.000 43.93542 ? 91  ASP B CG  1 
ATOM   3443 O OD1 . ASP B 1 91  ? -102.02741 -0.72650  -82.01307  1.000 36.38229 ? 91  ASP B OD1 1 
ATOM   3444 O OD2 . ASP B 1 91  ? -102.04762 1.32673   -81.21483  1.000 48.66266 ? 91  ASP B OD2 1 
ATOM   3445 N N   . TRP B 1 92  ? -105.28215 1.26102   -85.64005  1.000 27.64450 ? 92  TRP B N   1 
ATOM   3446 C CA  . TRP B 1 92  ? -106.58647 1.55230   -86.23037  1.000 28.25279 ? 92  TRP B CA  1 
ATOM   3447 C C   . TRP B 1 92  ? -107.15074 0.35436   -86.96931  1.000 31.44998 ? 92  TRP B C   1 
ATOM   3448 O O   . TRP B 1 92  ? -108.37056 0.19229   -87.04667  1.000 33.94985 ? 92  TRP B O   1 
ATOM   3449 C CB  . TRP B 1 92  ? -106.48875 2.75547   -87.17685  1.000 24.61968 ? 92  TRP B CB  1 
ATOM   3450 C CG  . TRP B 1 92  ? -105.84393 2.49641   -88.54224  1.000 28.44597 ? 92  TRP B CG  1 
ATOM   3451 C CD1 . TRP B 1 92  ? -104.59499 2.88382   -88.93932  1.000 26.97347 ? 92  TRP B CD1 1 
ATOM   3452 C CD2 . TRP B 1 92  ? -106.44705 1.86836   -89.69439  1.000 31.44759 ? 92  TRP B CD2 1 
ATOM   3453 N NE1 . TRP B 1 92  ? -104.37171 2.51128   -90.23986  1.000 28.65166 ? 92  TRP B NE1 1 
ATOM   3454 C CE2 . TRP B 1 92  ? -105.48859 1.88998   -90.73018  1.000 25.75941 ? 92  TRP B CE2 1 
ATOM   3455 C CE3 . TRP B 1 92  ? -107.70326 1.30114   -89.94990  1.000 28.48075 ? 92  TRP B CE3 1 
ATOM   3456 C CZ2 . TRP B 1 92  ? -105.74047 1.35441   -92.00227  1.000 29.67171 ? 92  TRP B CZ2 1 
ATOM   3457 C CZ3 . TRP B 1 92  ? -107.94922 0.75018   -91.20532  1.000 29.01018 ? 92  TRP B CZ3 1 
ATOM   3458 C CH2 . TRP B 1 92  ? -106.96849 0.78506   -92.22097  1.000 28.06271 ? 92  TRP B CH2 1 
ATOM   3459 N N   . VAL B 1 93  ? -106.27984 -0.48942  -87.51429  1.000 32.63671 ? 93  VAL B N   1 
ATOM   3460 C CA  . VAL B 1 93  ? -106.71663 -1.59247  -88.36019  1.000 30.45137 ? 93  VAL B CA  1 
ATOM   3461 C C   . VAL B 1 93  ? -107.66213 -2.50902  -87.60005  1.000 32.69064 ? 93  VAL B C   1 
ATOM   3462 O O   . VAL B 1 93  ? -108.62315 -3.04782  -88.16676  1.000 31.74477 ? 93  VAL B O   1 
ATOM   3463 C CB  . VAL B 1 93  ? -105.47993 -2.34490  -88.89418  1.000 28.39139 ? 93  VAL B CB  1 
ATOM   3464 C CG1 . VAL B 1 93  ? -105.86619 -3.59491  -89.66448  1.000 25.24896 ? 93  VAL B CG1 1 
ATOM   3465 C CG2 . VAL B 1 93  ? -104.68790 -1.42566  -89.77384  1.000 26.27534 ? 93  VAL B CG2 1 
ATOM   3466 N N   . PHE B 1 94  ? -107.41485 -2.69317  -86.30871  1.000 31.73824 ? 94  PHE B N   1 
ATOM   3467 C CA  . PHE B 1 94  ? -108.16502 -3.65911  -85.52602  1.000 35.23320 ? 94  PHE B CA  1 
ATOM   3468 C C   . PHE B 1 94  ? -109.28235 -3.03639  -84.70181  1.000 38.25449 ? 94  PHE B C   1 
ATOM   3469 O O   . PHE B 1 94  ? -110.10569 -3.77647  -84.16069  1.000 37.53373 ? 94  PHE B O   1 
ATOM   3470 C CB  . PHE B 1 94  ? -107.20650 -4.43595  -84.61380  1.000 34.13181 ? 94  PHE B CB  1 
ATOM   3471 C CG  . PHE B 1 94  ? -106.04961 -5.02913  -85.35421  1.000 33.85178 ? 94  PHE B CG  1 
ATOM   3472 C CD1 . PHE B 1 94  ? -106.22818 -6.15631  -86.16121  1.000 29.12713 ? 94  PHE B CD1 1 
ATOM   3473 C CD2 . PHE B 1 94  ? -104.80699 -4.41938  -85.31693  1.000 28.88449 ? 94  PHE B CD2 1 
ATOM   3474 C CE1 . PHE B 1 94  ? -105.17847 -6.68070  -86.88108  1.000 28.44963 ? 94  PHE B CE1 1 
ATOM   3475 C CE2 . PHE B 1 94  ? -103.74257 -4.94123  -86.04372  1.000 28.02433 ? 94  PHE B CE2 1 
ATOM   3476 C CZ  . PHE B 1 94  ? -103.92504 -6.07018  -86.82235  1.000 20.78863 ? 94  PHE B CZ  1 
ATOM   3477 N N   . GLN B 1 95  ? -109.34696 -1.71119  -84.60997  1.000 36.57994 ? 95  GLN B N   1 
ATOM   3478 C CA  . GLN B 1 95  ? -110.27407 -1.03556  -83.71706  1.000 38.21535 ? 95  GLN B CA  1 
ATOM   3479 C C   . GLN B 1 95  ? -111.39211 -0.33865  -84.48134  1.000 47.55100 ? 95  GLN B C   1 
ATOM   3480 O O   . GLN B 1 95  ? -111.24346 0.02784   -85.65459  1.000 42.57430 ? 95  GLN B O   1 
ATOM   3481 C CB  . GLN B 1 95  ? -109.54648 -0.01382  -82.84977  1.000 44.93640 ? 95  GLN B CB  1 
ATOM   3482 C CG  . GLN B 1 95  ? -109.04286 -0.60240  -81.55190  1.000 52.22557 ? 95  GLN B CG  1 
ATOM   3483 C CD  . GLN B 1 95  ? -107.64046 -0.15353  -81.23302  1.000 64.80479 ? 95  GLN B CD  1 
ATOM   3484 O OE1 . GLN B 1 95  ? -107.22197 0.94500   -81.62681  1.000 55.76936 ? 95  GLN B OE1 1 
ATOM   3485 N NE2 . GLN B 1 95  ? -106.89585 -0.99903  -80.51569  1.000 61.77043 ? 95  GLN B NE2 1 
ATOM   3486 N N   . ASP B 1 96  ? -112.52630 -0.18221  -83.79957  1.000 50.91177 ? 96  ASP B N   1 
ATOM   3487 C CA  . ASP B 1 96  ? -113.63799 0.63223   -84.27356  1.000 51.94990 ? 96  ASP B CA  1 
ATOM   3488 C C   . ASP B 1 96  ? -113.53209 2.03570   -83.66256  1.000 53.18014 ? 96  ASP B C   1 
ATOM   3489 O O   . ASP B 1 96  ? -112.48492 2.42213   -83.13040  1.000 57.74218 ? 96  ASP B O   1 
ATOM   3490 C CB  . ASP B 1 96  ? -114.98171 -0.06956  -83.96909  1.000 46.68370 ? 96  ASP B CB  1 
ATOM   3491 C CG  . ASP B 1 96  ? -115.25733 -0.25812  -82.46528  1.000 57.15295 ? 96  ASP B CG  1 
ATOM   3492 O OD1 . ASP B 1 96  ? -114.65271 0.44547   -81.62577  1.000 52.95902 ? 96  ASP B OD1 1 
ATOM   3493 O OD2 . ASP B 1 96  ? -116.11325 -1.11876  -82.12460  1.000 53.92498 ? 96  ASP B OD2 1 
ATOM   3494 N N   . GLY B 1 97  ? -114.61525 2.80772   -83.72348  1.000 55.36960 ? 97  GLY B N   1 
ATOM   3495 C CA  . GLY B 1 97  ? -114.56803 4.14614   -83.16276  1.000 59.93449 ? 97  GLY B CA  1 
ATOM   3496 C C   . GLY B 1 97  ? -114.38623 4.15552   -81.66038  1.000 61.25910 ? 97  GLY B C   1 
ATOM   3497 O O   . GLY B 1 97  ? -113.67440 5.01196   -81.12397  1.000 56.90086 ? 97  GLY B O   1 
ATOM   3498 N N   . GLN B 1 98  ? -115.00430 3.19562   -80.96276  1.000 62.56200 ? 98  GLN B N   1 
ATOM   3499 C CA  . GLN B 1 98  ? -114.99719 3.12364   -79.50681  1.000 61.54589 ? 98  GLN B CA  1 
ATOM   3500 C C   . GLN B 1 98  ? -113.70892 2.53134   -78.93777  1.000 60.73503 ? 98  GLN B C   1 
ATOM   3501 O O   . GLN B 1 98  ? -113.62073 2.35128   -77.72045  1.000 56.06463 ? 98  GLN B O   1 
ATOM   3502 C CB  . GLN B 1 98  ? -116.18533 2.27920   -79.02474  1.000 69.66409 ? 98  GLN B CB  1 
ATOM   3503 C CG  . GLN B 1 98  ? -117.59558 2.96235   -79.14159  1.000 71.69401 ? 98  GLN B CG  1 
ATOM   3504 C CD  . GLN B 1 98  ? -118.32410 3.13933   -77.78044  1.000 81.28166 ? 98  GLN B CD  1 
ATOM   3505 O OE1 . GLN B 1 98  ? -117.69390 3.12891   -76.68718  1.000 73.42952 ? 98  GLN B OE1 1 
ATOM   3506 N NE2 . GLN B 1 98  ? -119.65805 3.28561   -77.84522  1.000 65.28531 ? 98  GLN B NE2 1 
ATOM   3507 N N   . GLY B 1 99  ? -112.72200 2.19912   -79.78109  1.000 67.42652 ? 99  GLY B N   1 
ATOM   3508 C CA  . GLY B 1 99  ? -111.54080 1.48011   -79.35220  1.000 60.36795 ? 99  GLY B CA  1 
ATOM   3509 C C   . GLY B 1 99  ? -111.72026 -0.01444  -79.15217  1.000 64.69859 ? 99  GLY B C   1 
ATOM   3510 O O   . GLY B 1 99  ? -110.75690 -0.68737  -78.75370  1.000 69.60530 ? 99  GLY B O   1 
ATOM   3511 N N   . HIS B 1 100 ? -112.91252 -0.55871  -79.41066  1.000 57.47245 ? 100 HIS B N   1 
ATOM   3512 C CA  . HIS B 1 100 ? -113.14121 -1.99555  -79.31564  1.000 51.82988 ? 100 HIS B CA  1 
ATOM   3513 C C   . HIS B 1 100 ? -112.67959 -2.70064  -80.59048  1.000 46.78739 ? 100 HIS B C   1 
ATOM   3514 O O   . HIS B 1 100 ? -112.53398 -2.09241  -81.65418  1.000 46.20083 ? 100 HIS B O   1 
ATOM   3515 C CB  . HIS B 1 100 ? -114.62309 -2.30489  -79.07265  1.000 57.46873 ? 100 HIS B CB  1 
ATOM   3516 C CG  . HIS B 1 100 ? -115.20861 -1.56645  -77.90770  1.000 73.61901 ? 100 HIS B CG  1 
ATOM   3517 N ND1 . HIS B 1 100 ? -116.51069 -1.10838  -77.88777  1.000 65.34815 ? 100 HIS B ND1 1 
ATOM   3518 C CD2 . HIS B 1 100 ? -114.65654 -1.18278  -76.73166  1.000 74.20543 ? 100 HIS B CD2 1 
ATOM   3519 C CE1 . HIS B 1 100 ? -116.73520 -0.47947  -76.74725  1.000 70.43222 ? 100 HIS B CE1 1 
ATOM   3520 N NE2 . HIS B 1 100 ? -115.62606 -0.50874  -76.02936  1.000 79.42294 ? 100 HIS B NE2 1 
ATOM   3521 N N   . PHE B 1 101 ? -112.46588 -4.00735  -80.48256  1.000 35.62923 ? 101 PHE B N   1 
ATOM   3522 C CA  . PHE B 1 101 ? -112.00505 -4.76325  -81.63620  1.000 35.89684 ? 101 PHE B CA  1 
ATOM   3523 C C   . PHE B 1 101 ? -113.13149 -4.91722  -82.65093  1.000 42.01762 ? 101 PHE B C   1 
ATOM   3524 O O   . PHE B 1 101 ? -114.27834 -5.20423  -82.29642  1.000 41.23031 ? 101 PHE B O   1 
ATOM   3525 C CB  . PHE B 1 101 ? -111.47854 -6.13155  -81.20496  1.000 32.69425 ? 101 PHE B CB  1 
ATOM   3526 C CG  . PHE B 1 101 ? -110.13138 -6.07883  -80.53890  1.000 40.71696 ? 101 PHE B CG  1 
ATOM   3527 C CD1 . PHE B 1 101 ? -109.07630 -5.38853  -81.12199  1.000 46.50590 ? 101 PHE B CD1 1 
ATOM   3528 C CD2 . PHE B 1 101 ? -109.92273 -6.70012  -79.31223  1.000 50.00939 ? 101 PHE B CD2 1 
ATOM   3529 C CE1 . PHE B 1 101 ? -107.82218 -5.33496  -80.49995  1.000 49.27692 ? 101 PHE B CE1 1 
ATOM   3530 C CE2 . PHE B 1 101 ? -108.67362 -6.64830  -78.68511  1.000 46.69976 ? 101 PHE B CE2 1 
ATOM   3531 C CZ  . PHE B 1 101 ? -107.62565 -5.96499  -79.28286  1.000 42.17823 ? 101 PHE B CZ  1 
ATOM   3532 N N   . VAL B 1 102 ? -112.80167 -4.71220  -83.92491  1.000 34.66291 ? 102 VAL B N   1 
ATOM   3533 C CA  . VAL B 1 102 ? -113.78560 -4.85049  -84.98562  1.000 31.43076 ? 102 VAL B CA  1 
ATOM   3534 C C   . VAL B 1 102 ? -114.12790 -6.32083  -85.13347  1.000 34.81197 ? 102 VAL B C   1 
ATOM   3535 O O   . VAL B 1 102 ? -113.49324 -7.19033  -84.52826  1.000 32.17998 ? 102 VAL B O   1 
ATOM   3536 C CB  . VAL B 1 102 ? -113.28674 -4.26683  -86.31935  1.000 36.49896 ? 102 VAL B CB  1 
ATOM   3537 C CG1 . VAL B 1 102 ? -112.91648 -2.80477  -86.14820  1.000 39.32186 ? 102 VAL B CG1 1 
ATOM   3538 C CG2 . VAL B 1 102 ? -112.10442 -5.06778  -86.83233  1.000 34.05016 ? 102 VAL B CG2 1 
ATOM   3539 N N   . SER B 1 103 ? -115.14903 -6.59534  -85.92831  1.000 36.96133 ? 103 SER B N   1 
ATOM   3540 C CA  . SER B 1 103 ? -115.63034 -7.93182  -86.20502  1.000 31.66291 ? 103 SER B CA  1 
ATOM   3541 C C   . SER B 1 103 ? -114.76834 -8.59250  -87.27836  1.000 33.77479 ? 103 SER B C   1 
ATOM   3542 O O   . SER B 1 103 ? -113.99977 -7.93741  -87.98595  1.000 37.91001 ? 103 SER B O   1 
ATOM   3543 C CB  . SER B 1 103 ? -117.08370 -7.86291  -86.67249  1.000 35.50425 ? 103 SER B CB  1 
ATOM   3544 O OG  . SER B 1 103 ? -117.13701 -7.35567  -87.99750  1.000 34.22090 ? 103 SER B OG  1 
ATOM   3545 N N   . ARG B 1 104 ? -114.93850 -9.90763  -87.41728  1.000 32.66219 ? 104 ARG B N   1 
ATOM   3546 C CA  . ARG B 1 104 ? -114.30970 -10.63520 -88.51427  1.000 35.25307 ? 104 ARG B CA  1 
ATOM   3547 C C   . ARG B 1 104 ? -114.56069 -9.95891  -89.85907  1.000 37.17289 ? 104 ARG B C   1 
ATOM   3548 O O   . ARG B 1 104 ? -113.61856 -9.68800  -90.62005  1.000 32.46438 ? 104 ARG B O   1 
ATOM   3549 C CB  . ARG B 1 104 ? -114.82147 -12.07293 -88.54492  1.000 33.79246 ? 104 ARG B CB  1 
ATOM   3550 C CG  . ARG B 1 104 ? -114.61767 -12.73691 -89.88143  1.000 32.17707 ? 104 ARG B CG  1 
ATOM   3551 C CD  . ARG B 1 104 ? -115.21112 -14.13048 -89.89684  1.000 27.79709 ? 104 ARG B CD  1 
ATOM   3552 N NE  . ARG B 1 104 ? -115.12464 -14.73482 -91.22054  1.000 31.75475 ? 104 ARG B NE  1 
ATOM   3553 C CZ  . ARG B 1 104 ? -114.18308 -15.59547 -91.59642  1.000 40.63337 ? 104 ARG B CZ  1 
ATOM   3554 N NH1 . ARG B 1 104 ? -113.23269 -15.95201 -90.75084  1.000 37.78117 ? 104 ARG B NH1 1 
ATOM   3555 N NH2 . ARG B 1 104 ? -114.18755 -16.09644 -92.82569  1.000 44.78598 ? 104 ARG B NH2 1 
ATOM   3556 N N   . ASP B 1 105 ? -115.82980 -9.67628  -90.16631  1.000 31.11169 ? 105 ASP B N   1 
ATOM   3557 C CA  . ASP B 1 105 ? -116.18544 -9.16087  -91.48990  1.000 33.82151 ? 105 ASP B CA  1 
ATOM   3558 C C   . ASP B 1 105 ? -115.57121 -7.78863  -91.74907  1.000 32.44220 ? 105 ASP B C   1 
ATOM   3559 O O   . ASP B 1 105 ? -115.14240 -7.49565  -92.87172  1.000 37.37293 ? 105 ASP B O   1 
ATOM   3560 C CB  . ASP B 1 105 ? -117.71323 -9.08884  -91.63920  1.000 41.82540 ? 105 ASP B CB  1 
ATOM   3561 C CG  . ASP B 1 105 ? -118.34256 -10.44242 -91.92147  1.000 37.46104 ? 105 ASP B CG  1 
ATOM   3562 O OD1 . ASP B 1 105 ? -117.65103 -11.32118 -92.48386  1.000 42.37945 ? 105 ASP B OD1 1 
ATOM   3563 O OD2 . ASP B 1 105 ? -119.52925 -10.62342 -91.58081  1.000 53.43652 ? 105 ASP B OD2 1 
ATOM   3564 N N   . VAL B 1 106 ? -115.54639 -6.92254  -90.73271  1.000 29.09817 ? 106 VAL B N   1 
ATOM   3565 C CA  . VAL B 1 106 ? -114.97238 -5.59759  -90.92151  1.000 35.94666 ? 106 VAL B CA  1 
ATOM   3566 C C   . VAL B 1 106 ? -113.45770 -5.68750  -91.11148  1.000 33.93012 ? 106 VAL B C   1 
ATOM   3567 O O   . VAL B 1 106 ? -112.87323 -4.90461  -91.87457  1.000 34.34079 ? 106 VAL B O   1 
ATOM   3568 C CB  . VAL B 1 106 ? -115.35226 -4.67647  -89.74444  1.000 35.34211 ? 106 VAL B CB  1 
ATOM   3569 C CG1 . VAL B 1 106 ? -114.58971 -3.35200  -89.81729  1.000 26.16183 ? 106 VAL B CG1 1 
ATOM   3570 C CG2 . VAL B 1 106 ? -116.85107 -4.41533  -89.74369  1.000 35.11730 ? 106 VAL B CG2 1 
ATOM   3571 N N   . LEU B 1 107 ? -112.79467 -6.64014  -90.44996  1.000 31.06811 ? 107 LEU B N   1 
ATOM   3572 C CA  . LEU B 1 107 ? -111.35227 -6.74920  -90.64666  1.000 32.09363 ? 107 LEU B CA  1 
ATOM   3573 C C   . LEU B 1 107 ? -111.04432 -7.35760  -92.00387  1.000 28.93339 ? 107 LEU B C   1 
ATOM   3574 O O   . LEU B 1 107 ? -110.06889 -6.96295  -92.64998  1.000 32.99116 ? 107 LEU B O   1 
ATOM   3575 C CB  . LEU B 1 107 ? -110.69574 -7.55051  -89.51359  1.000 26.71861 ? 107 LEU B CB  1 
ATOM   3576 C CG  . LEU B 1 107 ? -109.14649 -7.55404  -89.49292  1.000 31.25460 ? 107 LEU B CG  1 
ATOM   3577 C CD1 . LEU B 1 107 ? -108.56146 -6.14122  -89.61201  1.000 24.36537 ? 107 LEU B CD1 1 
ATOM   3578 C CD2 . LEU B 1 107 ? -108.57539 -8.25497  -88.25192  1.000 21.07945 ? 107 LEU B CD2 1 
ATOM   3579 N N   . LEU B 1 108 ? -111.89299 -8.26343  -92.48850  1.000 29.36624 ? 108 LEU B N   1 
ATOM   3580 C CA  . LEU B 1 108 ? -111.69266 -8.77154  -93.84135  1.000 27.92038 ? 108 LEU B CA  1 
ATOM   3581 C C   . LEU B 1 108 ? -111.84291 -7.65967  -94.87822  1.000 32.28594 ? 108 LEU B C   1 
ATOM   3582 O O   . LEU B 1 108 ? -111.04834 -7.57589  -95.82246  1.000 30.70092 ? 108 LEU B O   1 
ATOM   3583 C CB  . LEU B 1 108 ? -112.65162 -9.92288  -94.11324  1.000 32.96075 ? 108 LEU B CB  1 
ATOM   3584 C CG  . LEU B 1 108 ? -112.27054 -11.21445 -93.37624  1.000 32.49037 ? 108 LEU B CG  1 
ATOM   3585 C CD1 . LEU B 1 108 ? -113.32016 -12.30569 -93.56304  1.000 31.10864 ? 108 LEU B CD1 1 
ATOM   3586 C CD2 . LEU B 1 108 ? -110.90143 -11.71187 -93.80540  1.000 23.84406 ? 108 LEU B CD2 1 
ATOM   3587 N N   . GLU B 1 109 ? -112.82746 -6.77152  -94.70705  1.000 37.13647 ? 109 GLU B N   1 
ATOM   3588 C CA  . GLU B 1 109 ? -112.95976 -5.64310  -95.63002  1.000 33.53290 ? 109 GLU B CA  1 
ATOM   3589 C C   . GLU B 1 109 ? -111.71622 -4.76489  -95.60850  1.000 30.86038 ? 109 GLU B C   1 
ATOM   3590 O O   . GLU B 1 109 ? -111.21881 -4.35239  -96.66129  1.000 30.45376 ? 109 GLU B O   1 
ATOM   3591 C CB  . GLU B 1 109 ? -114.18266 -4.79812  -95.29191  1.000 27.01801 ? 109 GLU B CB  1 
ATOM   3592 C CG  . GLU B 1 109 ? -115.51219 -5.32597  -95.81759  1.000 53.66066 ? 109 GLU B CG  1 
ATOM   3593 C CD  . GLU B 1 109 ? -116.71252 -4.77671  -95.02977  1.000 64.70297 ? 109 GLU B CD  1 
ATOM   3594 O OE1 . GLU B 1 109 ? -116.64223 -3.59641  -94.59866  1.000 56.69330 ? 109 GLU B OE1 1 
ATOM   3595 O OE2 . GLU B 1 109 ? -117.73743 -5.49932  -94.89462  1.000 55.25210 ? 109 GLU B OE2 1 
ATOM   3596 N N   . ARG B 1 110 ? -111.21912 -4.44544  -94.40990  1.000 26.42742 ? 110 ARG B N   1 
ATOM   3597 C CA  . ARG B 1 110 ? -110.04123 -3.58947  -94.28254  1.000 26.80073 ? 110 ARG B CA  1 
ATOM   3598 C C   . ARG B 1 110 ? -108.81034 -4.25983  -94.87537  1.000 25.18912 ? 110 ARG B C   1 
ATOM   3599 O O   . ARG B 1 110 ? -108.00984 -3.61194  -95.56168  1.000 23.81634 ? 110 ARG B O   1 
ATOM   3600 C CB  . ARG B 1 110 ? -109.80313 -3.25321  -92.81075  1.000 23.63939 ? 110 ARG B CB  1 
ATOM   3601 C CG  . ARG B 1 110 ? -110.85339 -2.33535  -92.21609  1.000 24.46359 ? 110 ARG B CG  1 
ATOM   3602 C CD  . ARG B 1 110 ? -110.66158 -2.10901  -90.72193  1.000 27.37769 ? 110 ARG B CD  1 
ATOM   3603 N NE  . ARG B 1 110 ? -111.51899 -1.03175  -90.21969  1.000 34.02384 ? 110 ARG B NE  1 
ATOM   3604 C CZ  . ARG B 1 110 ? -111.56331 -0.61852  -88.95313  1.000 34.74792 ? 110 ARG B CZ  1 
ATOM   3605 N NH1 . ARG B 1 110 ? -110.79685 -1.18775  -88.03159  1.000 27.12667 ? 110 ARG B NH1 1 
ATOM   3606 N NH2 . ARG B 1 110 ? -112.37304 0.37444   -88.60748  1.000 36.48629 ? 110 ARG B NH2 1 
ATOM   3607 N N   . MET B 1 111 ? -108.64778 -5.55934  -94.62214  1.000 22.77247 ? 111 MET B N   1 
ATOM   3608 C CA  . MET B 1 111 ? -107.54828 -6.29850  -95.22334  1.000 21.31536 ? 111 MET B CA  1 
ATOM   3609 C C   . MET B 1 111 ? -107.65404 -6.28940  -96.74131  1.000 24.68813 ? 111 MET B C   1 
ATOM   3610 O O   . MET B 1 111 ? -106.67232 -6.01047  -97.44492  1.000 22.63822 ? 111 MET B O   1 
ATOM   3611 C CB  . MET B 1 111 ? -107.53025 -7.73303  -94.69662  1.000 21.73731 ? 111 MET B CB  1 
ATOM   3612 C CG  . MET B 1 111 ? -106.50141 -8.61451  -95.37174  1.000 21.64602 ? 111 MET B CG  1 
ATOM   3613 S SD  . MET B 1 111 ? -106.74999 -10.36137 -95.00218  1.000 27.53163 ? 111 MET B SD  1 
ATOM   3614 C CE  . MET B 1 111 ? -106.12971 -10.45542 -93.32417  1.000 21.79107 ? 111 MET B CE  1 
ATOM   3615 N N   . LYS B 1 112 ? -108.84386 -6.59537  -97.26643  1.000 30.73969 ? 112 LYS B N   1 
ATOM   3616 C CA  . LYS B 1 112 ? -109.04250 -6.61787  -98.71442  1.000 29.56657 ? 112 LYS B CA  1 
ATOM   3617 C C   . LYS B 1 112 ? -108.75093 -5.25529  -99.33375  1.000 21.22252 ? 112 LYS B C   1 
ATOM   3618 O O   . LYS B 1 112 ? -108.04189 -5.16003  -100.34257 1.000 24.25011 ? 112 LYS B O   1 
ATOM   3619 C CB  . LYS B 1 112 ? -110.46990 -7.05510  -99.04529  1.000 31.13858 ? 112 LYS B CB  1 
ATOM   3620 C CG  . LYS B 1 112 ? -110.72912 -7.08247  -100.53794 1.000 33.09338 ? 112 LYS B CG  1 
ATOM   3621 C CD  . LYS B 1 112 ? -112.09422 -7.66620  -100.86727 1.000 43.10607 ? 112 LYS B CD  1 
ATOM   3622 C CE  . LYS B 1 112 ? -112.33283 -7.73623  -102.37284 1.000 43.04493 ? 112 LYS B CE  1 
ATOM   3623 N NZ  . LYS B 1 112 ? -113.70429 -8.26340  -102.66194 1.000 62.03632 ? 112 LYS B NZ  1 
ATOM   3624 N N   . CYS B 1 113 ? -109.27840 -4.18597  -98.72063  1.000 22.78274 ? 113 CYS B N   1 
ATOM   3625 C CA  . CYS B 1 113 ? -109.06865 -2.83029  -99.22869  1.000 23.02070 ? 113 CYS B CA  1 
ATOM   3626 C C   . CYS B 1 113 ? -107.58616 -2.47368  -99.28685  1.000 25.03628 ? 113 CYS B C   1 
ATOM   3627 O O   . CYS B 1 113 ? -107.11266 -1.90822  -100.28288 1.000 24.97827 ? 113 CYS B O   1 
ATOM   3628 C CB  . CYS B 1 113 ? -109.81003 -1.82163  -98.35244  1.000 23.44544 ? 113 CYS B CB  1 
ATOM   3629 S SG  . CYS B 1 113 ? -109.81496 -0.13187  -99.03849  1.000 37.66343 ? 113 CYS B SG  1 
ATOM   3630 N N   . HIS B 1 114 ? -106.84483 -2.76412  -98.20875  1.000 25.57619 ? 114 HIS B N   1 
ATOM   3631 C CA  . HIS B 1 114 ? -105.40444 -2.48756  -98.18327  1.000 24.41262 ? 114 HIS B CA  1 
ATOM   3632 C C   . HIS B 1 114 ? -104.66728 -3.31894  -99.22074  1.000 23.26014 ? 114 HIS B C   1 
ATOM   3633 O O   . HIS B 1 114 ? -103.85152 -2.79802  -99.98951  1.000 21.36335 ? 114 HIS B O   1 
ATOM   3634 C CB  . HIS B 1 114 ? -104.84553 -2.77170  -96.78358  1.000 23.43969 ? 114 HIS B CB  1 
ATOM   3635 C CG  . HIS B 1 114 ? -103.36986 -2.58272  -96.66284  1.000 24.91105 ? 114 HIS B CG  1 
ATOM   3636 N ND1 . HIS B 1 114 ? -102.80410 -1.37612  -96.30501  1.000 22.91919 ? 114 HIS B ND1 1 
ATOM   3637 C CD2 . HIS B 1 114 ? -102.33957 -3.44840  -96.84362  1.000 22.20931 ? 114 HIS B CD2 1 
ATOM   3638 C CE1 . HIS B 1 114 ? -101.48787 -1.50438  -96.28381  1.000 25.21929 ? 114 HIS B CE1 1 
ATOM   3639 N NE2 . HIS B 1 114 ? -101.18174 -2.74831  -96.61192  1.000 18.50507 ? 114 HIS B NE2 1 
ATOM   3640 N N   . ILE B 1 115 ? -104.94193 -4.62613  -99.25369  1.000 22.64892 ? 115 ILE B N   1 
ATOM   3641 C CA  . ILE B 1 115 ? -104.22338 -5.49746  -100.17653 1.000 20.90418 ? 115 ILE B CA  1 
ATOM   3642 C C   . ILE B 1 115 ? -104.48034 -5.05931  -101.60862 1.000 27.60558 ? 115 ILE B C   1 
ATOM   3643 O O   . ILE B 1 115 ? -103.55713 -4.94430  -102.42697 1.000 26.84391 ? 115 ILE B O   1 
ATOM   3644 C CB  . ILE B 1 115 ? -104.63661 -6.95894  -99.96056  1.000 20.98242 ? 115 ILE B CB  1 
ATOM   3645 C CG1 . ILE B 1 115 ? -104.07076 -7.46735  -98.63613  1.000 20.11702 ? 115 ILE B CG1 1 
ATOM   3646 C CG2 . ILE B 1 115 ? -104.19691 -7.79373  -101.16436 1.000 19.84101 ? 115 ILE B CG2 1 
ATOM   3647 C CD1 . ILE B 1 115 ? -104.39653 -8.93670  -98.32939  1.000 14.95862 ? 115 ILE B CD1 1 
ATOM   3648 N N   . SER B 1 116 ? -105.75169 -4.76896  -101.91273 1.000 22.76235 ? 116 SER B N   1 
ATOM   3649 C CA  . SER B 1 116 ? -106.15778 -4.44539  -103.27422 1.000 27.87449 ? 116 SER B CA  1 
ATOM   3650 C C   . SER B 1 116 ? -105.54405 -3.12023  -103.72297 1.000 22.58113 ? 116 SER B C   1 
ATOM   3651 O O   . SER B 1 116 ? -104.97635 -3.02132  -104.81187 1.000 27.31423 ? 116 SER B O   1 
ATOM   3652 C CB  . SER B 1 116 ? -107.69507 -4.44393  -103.34504 1.000 29.13015 ? 116 SER B CB  1 
ATOM   3653 O OG  . SER B 1 116 ? -108.17979 -3.66998  -104.43144 1.000 36.59903 ? 116 SER B OG  1 
ATOM   3654 N N   . THR B 1 117 ? -105.59631 -2.09882  -102.86729 1.000 20.99429 ? 117 THR B N   1 
ATOM   3655 C CA  . THR B 1 117 ? -104.97452 -0.81777  -103.19650 1.000 24.11188 ? 117 THR B CA  1 
ATOM   3656 C C   . THR B 1 117 ? -103.47134 -0.95143  -103.37122 1.000 27.65669 ? 117 THR B C   1 
ATOM   3657 O O   . THR B 1 117 ? -102.88841 -0.39796  -104.31266 1.000 24.27480 ? 117 THR B O   1 
ATOM   3658 C CB  . THR B 1 117 ? -105.26298 0.17416   -102.08223 1.000 25.24229 ? 117 THR B CB  1 
ATOM   3659 O OG1 . THR B 1 117 ? -106.63378 0.03522   -101.69050 1.000 20.27462 ? 117 THR B OG1 1 
ATOM   3660 C CG2 . THR B 1 117 ? -104.94617 1.59115   -102.49691 1.000 18.37519 ? 117 THR B CG2 1 
ATOM   3661 N N   . VAL B 1 118 ? -102.81652 -1.66289  -102.45752 1.000 23.31483 ? 118 VAL B N   1 
ATOM   3662 C CA  . VAL B 1 118 ? -101.36367 -1.72111  -102.48729 1.000 19.83747 ? 118 VAL B CA  1 
ATOM   3663 C C   . VAL B 1 118 ? -100.89369 -2.55155  -103.67077 1.000 21.23930 ? 118 VAL B C   1 
ATOM   3664 O O   . VAL B 1 118 ? -100.04768 -2.11448  -104.46458 1.000 21.15835 ? 118 VAL B O   1 
ATOM   3665 C CB  . VAL B 1 118 ? -100.82714 -2.28457  -101.15675 1.000 20.33562 ? 118 VAL B CB  1 
ATOM   3666 C CG1 . VAL B 1 118 ? -99.35761  -2.65556  -101.31970 1.000 17.17175 ? 118 VAL B CG1 1 
ATOM   3667 C CG2 . VAL B 1 118 ? -100.99960 -1.27257  -100.04645 1.000 18.13212 ? 118 VAL B CG2 1 
ATOM   3668 N N   . VAL B 1 119 ? -101.45182 -3.75848  -103.81776 1.000 25.38402 ? 119 VAL B N   1 
ATOM   3669 C CA  . VAL B 1 119 ? -100.98685 -4.68358  -104.84021 1.000 21.68801 ? 119 VAL B CA  1 
ATOM   3670 C C   . VAL B 1 119 ? -101.28735 -4.15075  -106.23256 1.000 27.50350 ? 119 VAL B C   1 
ATOM   3671 O O   . VAL B 1 119 ? -100.45537 -4.25848  -107.14275 1.000 25.16039 ? 119 VAL B O   1 
ATOM   3672 C CB  . VAL B 1 119 ? -101.62655 -6.05457  -104.61131 1.000 23.50636 ? 119 VAL B CB  1 
ATOM   3673 C CG1 . VAL B 1 119 ? -101.36342 -6.97961  -105.81424 1.000 25.37014 ? 119 VAL B CG1 1 
ATOM   3674 C CG2 . VAL B 1 119 ? -101.13667 -6.64809  -103.30275 1.000 22.18615 ? 119 VAL B CG2 1 
ATOM   3675 N N   . ARG B 1 120 ? -102.47335 -3.56877  -106.42705 1.000 23.90012 ? 120 ARG B N   1 
ATOM   3676 C CA  . ARG B 1 120 ? -102.80681 -3.06562  -107.75822 1.000 29.07947 ? 120 ARG B CA  1 
ATOM   3677 C C   . ARG B 1 120 ? -101.93596 -1.87825  -108.14134 1.000 25.42053 ? 120 ARG B C   1 
ATOM   3678 O O   . ARG B 1 120 ? -101.59251 -1.73295  -109.31340 1.000 25.15440 ? 120 ARG B O   1 
ATOM   3679 C CB  . ARG B 1 120 ? -104.29966 -2.70857  -107.86720 1.000 28.46094 ? 120 ARG B CB  1 
ATOM   3680 C CG  . ARG B 1 120 ? -105.22114 -3.91465  -107.60152 1.000 42.46652 ? 120 ARG B CG  1 
ATOM   3681 C CD  . ARG B 1 120 ? -106.73148 -3.65427  -107.80095 1.000 46.85447 ? 120 ARG B CD  1 
ATOM   3682 N NE  . ARG B 1 120 ? -107.39373 -4.85129  -108.34462 1.000 51.95452 ? 120 ARG B NE  1 
ATOM   3683 C CZ  . ARG B 1 120 ? -107.48014 -5.14386  -109.64479 1.000 57.58652 ? 120 ARG B CZ  1 
ATOM   3684 N NH1 . ARG B 1 120 ? -106.95003 -4.32164  -110.55123 1.000 48.33652 ? 120 ARG B NH1 1 
ATOM   3685 N NH2 . ARG B 1 120 ? -108.08822 -6.26478  -110.04388 1.000 57.06118 ? 120 ARG B NH2 1 
ATOM   3686 N N   . ARG B 1 121 ? -101.51677 -1.04969  -107.17912 1.000 29.14584 ? 121 ARG B N   1 
ATOM   3687 C CA  . ARG B 1 121 ? -100.66320 0.08204   -107.54513 1.000 25.56516 ? 121 ARG B CA  1 
ATOM   3688 C C   . ARG B 1 121 ? -99.39168  -0.37662  -108.23556 1.000 29.17847 ? 121 ARG B C   1 
ATOM   3689 O O   . ARG B 1 121 ? -98.90790  0.29559   -109.15599 1.000 32.78966 ? 121 ARG B O   1 
ATOM   3690 C CB  . ARG B 1 121 ? -100.30686 0.92528   -106.32542 1.000 22.71165 ? 121 ARG B CB  1 
ATOM   3691 C CG  . ARG B 1 121 ? -99.41397  2.11753   -106.70405 1.000 25.48296 ? 121 ARG B CG  1 
ATOM   3692 C CD  . ARG B 1 121 ? -99.25007  3.05188   -105.53993 1.000 18.04142 ? 121 ARG B CD  1 
ATOM   3693 N NE  . ARG B 1 121 ? -98.46599  4.25653   -105.83034 1.000 22.26861 ? 121 ARG B NE  1 
ATOM   3694 C CZ  . ARG B 1 121 ? -98.95266  5.35764   -106.39736 1.000 23.75168 ? 121 ARG B CZ  1 
ATOM   3695 N NH1 . ARG B 1 121 ? -100.22195 5.40886   -106.78656 1.000 25.02812 ? 121 ARG B NH1 1 
ATOM   3696 N NH2 . ARG B 1 121 ? -98.16969  6.40890   -106.59292 1.000 23.28445 ? 121 ARG B NH2 1 
ATOM   3697 N N   . TYR B 1 122 ? -98.86716  -1.53794  -107.84355 1.000 31.15484 ? 122 TYR B N   1 
ATOM   3698 C CA  . TYR B 1 122 ? -97.58642  -2.03776  -108.33373 1.000 30.33325 ? 122 TYR B CA  1 
ATOM   3699 C C   . TYR B 1 122 ? -97.72203  -3.25730  -109.23338 1.000 27.38091 ? 122 TYR B C   1 
ATOM   3700 O O   . TYR B 1 122 ? -96.71025  -3.89369  -109.53852 1.000 25.20123 ? 122 TYR B O   1 
ATOM   3701 C CB  . TYR B 1 122 ? -96.66612  -2.34481  -107.14513 1.000 23.06777 ? 122 TYR B CB  1 
ATOM   3702 C CG  . TYR B 1 122 ? -96.40517  -1.10447  -106.32464 1.000 20.20346 ? 122 TYR B CG  1 
ATOM   3703 C CD1 . TYR B 1 122 ? -95.71772  -0.02334  -106.86769 1.000 17.67698 ? 122 TYR B CD1 1 
ATOM   3704 C CD2 . TYR B 1 122 ? -96.88267  -0.99386  -105.03175 1.000 20.55686 ? 122 TYR B CD2 1 
ATOM   3705 C CE1 . TYR B 1 122 ? -95.49525  1.13029   -106.12337 1.000 20.50989 ? 122 TYR B CE1 1 
ATOM   3706 C CE2 . TYR B 1 122 ? -96.67194  0.14701   -104.28397 1.000 18.66022 ? 122 TYR B CE2 1 
ATOM   3707 C CZ  . TYR B 1 122 ? -95.98281  1.20601   -104.83026 1.000 25.33995 ? 122 TYR B CZ  1 
ATOM   3708 O OH  . TYR B 1 122 ? -95.77504  2.33478   -104.05992 1.000 22.50962 ? 122 TYR B OH  1 
ATOM   3709 N N   . LYS B 1 123 ? -98.94507  -3.60845  -109.65049 1.000 28.51448 ? 123 LYS B N   1 
ATOM   3710 C CA  . LYS B 1 123 ? -99.13456  -4.64446  -110.66226 1.000 32.75900 ? 123 LYS B CA  1 
ATOM   3711 C C   . LYS B 1 123 ? -98.24961  -4.36398  -111.87210 1.000 32.84989 ? 123 LYS B C   1 
ATOM   3712 O O   . LYS B 1 123 ? -98.13525  -3.22318  -112.32560 1.000 34.15207 ? 123 LYS B O   1 
ATOM   3713 C CB  . LYS B 1 123 ? -100.60772 -4.71820  -111.09420 1.000 36.82599 ? 123 LYS B CB  1 
ATOM   3714 C CG  . LYS B 1 123 ? -100.97955 -6.01515  -111.82999 1.000 40.41652 ? 123 LYS B CG  1 
ATOM   3715 C CD  . LYS B 1 123 ? -102.27821 -5.90938  -112.65151 1.000 37.01890 ? 123 LYS B CD  1 
ATOM   3716 C CE  . LYS B 1 123 ? -103.51706 -5.92797  -111.74366 1.000 49.48652 ? 123 LYS B CE  1 
ATOM   3717 N NZ  . LYS B 1 123 ? -104.59275 -6.89261  -112.17619 1.000 38.97479 ? 123 LYS B NZ  1 
ATOM   3718 N N   . GLY B 1 124 ? -97.58578  -5.40675  -112.36893 1.000 29.57548 ? 124 GLY B N   1 
ATOM   3719 C CA  . GLY B 1 124 ? -96.66806  -5.26662  -113.47325 1.000 34.02713 ? 124 GLY B CA  1 
ATOM   3720 C C   . GLY B 1 124 ? -95.25291  -4.87053  -113.10769 1.000 34.85460 ? 124 GLY B C   1 
ATOM   3721 O O   . GLY B 1 124 ? -94.32793  -5.15075  -113.87984 1.000 44.10884 ? 124 GLY B O   1 
ATOM   3722 N N   . LYS B 1 125 ? -95.04480  -4.22046  -111.96910 1.000 35.54470 ? 125 LYS B N   1 
ATOM   3723 C CA  . LYS B 1 125 ? -93.70648  -3.84666  -111.53198 1.000 30.78247 ? 125 LYS B CA  1 
ATOM   3724 C C   . LYS B 1 125 ? -93.16976  -4.72501  -110.41212 1.000 35.24352 ? 125 LYS B C   1 
ATOM   3725 O O   . LYS B 1 125 ? -91.96369  -4.98157  -110.36396 1.000 28.86795 ? 125 LYS B O   1 
ATOM   3726 C CB  . LYS B 1 125 ? -93.69300  -2.38651  -111.06850 1.000 29.74531 ? 125 LYS B CB  1 
ATOM   3727 C CG  . LYS B 1 125 ? -94.36058  -1.44482  -112.05571 1.000 36.98943 ? 125 LYS B CG  1 
ATOM   3728 C CD  . LYS B 1 125 ? -94.32531  -0.01435  -111.56398 1.000 42.75628 ? 125 LYS B CD  1 
ATOM   3729 C CE  . LYS B 1 125 ? -95.06008  0.91303   -112.52092 1.000 49.50452 ? 125 LYS B CE  1 
ATOM   3730 N NZ  . LYS B 1 125 ? -94.82863  2.32809   -112.12708 1.000 54.40968 ? 125 LYS B NZ  1 
ATOM   3731 N N   . ILE B 1 126 ? -94.03699  -5.18203  -109.51542 1.000 27.51446 ? 126 ILE B N   1 
ATOM   3732 C CA  . ILE B 1 126 ? -93.67104  -6.08193  -108.43796 1.000 23.26353 ? 126 ILE B CA  1 
ATOM   3733 C C   . ILE B 1 126 ? -94.14770  -7.46911  -108.82686 1.000 23.24219 ? 126 ILE B C   1 
ATOM   3734 O O   . ILE B 1 126 ? -95.34313  -7.68025  -109.05878 1.000 35.14991 ? 126 ILE B O   1 
ATOM   3735 C CB  . ILE B 1 126 ? -94.27678  -5.63781  -107.09824 1.000 20.66278 ? 126 ILE B CB  1 
ATOM   3736 C CG1 . ILE B 1 126 ? -93.62859  -4.33101  -106.62636 1.000 23.56056 ? 126 ILE B CG1 1 
ATOM   3737 C CG2 . ILE B 1 126 ? -94.12744  -6.73581  -106.06686 1.000 18.33937 ? 126 ILE B CG2 1 
ATOM   3738 C CD1 . ILE B 1 126 ? -94.01295  -3.92257  -105.21262 1.000 22.38548 ? 126 ILE B CD1 1 
ATOM   3739 N N   . TYR B 1 127 ? -93.21314  -8.41481  -108.90247 1.000 26.39157 ? 127 TYR B N   1 
ATOM   3740 C CA  . TYR B 1 127 ? -93.52760  -9.74545  -109.39573 1.000 26.97696 ? 127 TYR B CA  1 
ATOM   3741 C C   . TYR B 1 127 ? -93.89612  -10.73607 -108.30262 1.000 28.95399 ? 127 TYR B C   1 
ATOM   3742 O O   . TYR B 1 127 ? -94.50353  -11.76768 -108.61360 1.000 32.66558 ? 127 TYR B O   1 
ATOM   3743 C CB  . TYR B 1 127 ? -92.36001  -10.28175 -110.23691 1.000 29.48688 ? 127 TYR B CB  1 
ATOM   3744 C CG  . TYR B 1 127 ? -91.22754  -10.99887 -109.52125 1.000 31.30172 ? 127 TYR B CG  1 
ATOM   3745 C CD1 . TYR B 1 127 ? -90.18324  -10.29069 -108.92255 1.000 31.26659 ? 127 TYR B CD1 1 
ATOM   3746 C CD2 . TYR B 1 127 ? -91.16983  -12.39493 -109.49172 1.000 31.94078 ? 127 TYR B CD2 1 
ATOM   3747 C CE1 . TYR B 1 127 ? -89.10593  -10.96456 -108.28818 1.000 24.44973 ? 127 TYR B CE1 1 
ATOM   3748 C CE2 . TYR B 1 127 ? -90.10710  -13.07127 -108.85594 1.000 32.21123 ? 127 TYR B CE2 1 
ATOM   3749 C CZ  . TYR B 1 127 ? -89.08225  -12.34576 -108.26232 1.000 28.29508 ? 127 TYR B CZ  1 
ATOM   3750 O OH  . TYR B 1 127 ? -88.03565  -13.00634 -107.64915 1.000 35.62133 ? 127 TYR B OH  1 
ATOM   3751 N N   . CYS B 1 128 ? -93.57098  -10.46349 -107.03939 1.000 24.49747 ? 128 CYS B N   1 
ATOM   3752 C CA  . CYS B 1 128 ? -94.03049  -11.36028 -105.99295 1.000 27.56227 ? 128 CYS B CA  1 
ATOM   3753 C C   . CYS B 1 128 ? -94.27182  -10.56601 -104.71269 1.000 25.57377 ? 128 CYS B C   1 
ATOM   3754 O O   . CYS B 1 128 ? -93.75781  -9.45826  -104.53204 1.000 24.82070 ? 128 CYS B O   1 
ATOM   3755 C CB  . CYS B 1 128 ? -93.04046  -12.51338 -105.74323 1.000 25.93405 ? 128 CYS B CB  1 
ATOM   3756 S SG  . CYS B 1 128 ? -91.39839  -12.00979 -105.13640 1.000 28.29864 ? 128 CYS B SG  1 
ATOM   3757 N N   . TRP B 1 129 ? -95.05969  -11.16397 -103.81763 1.000 17.42255 ? 129 TRP B N   1 
ATOM   3758 C CA  . TRP B 1 129 ? -95.46327  -10.53440 -102.56644 1.000 18.84078 ? 129 TRP B CA  1 
ATOM   3759 C C   . TRP B 1 129 ? -95.31172  -11.50746 -101.40276 1.000 24.05975 ? 129 TRP B C   1 
ATOM   3760 O O   . TRP B 1 129 ? -95.77578  -12.64967 -101.47465 1.000 27.42466 ? 129 TRP B O   1 
ATOM   3761 C CB  . TRP B 1 129 ? -96.91958  -10.05139 -102.63688 1.000 19.16883 ? 129 TRP B CB  1 
ATOM   3762 C CG  . TRP B 1 129 ? -97.03443  -8.63073  -103.12295 1.000 26.60204 ? 129 TRP B CG  1 
ATOM   3763 C CD1 . TRP B 1 129 ? -97.34913  -8.21435  -104.39075 1.000 17.07418 ? 129 TRP B CD1 1 
ATOM   3764 C CD2 . TRP B 1 129 ? -96.79866  -7.43689  -102.35589 1.000 18.96868 ? 129 TRP B CD2 1 
ATOM   3765 N NE1 . TRP B 1 129 ? -97.35125  -6.84201  -104.44733 1.000 18.35186 ? 129 TRP B NE1 1 
ATOM   3766 C CE2 . TRP B 1 129 ? -97.01419  -6.33592  -103.22144 1.000 19.13483 ? 129 TRP B CE2 1 
ATOM   3767 C CE3 . TRP B 1 129 ? -96.42731  -7.19064  -101.02253 1.000 23.58681 ? 129 TRP B CE3 1 
ATOM   3768 C CZ2 . TRP B 1 129 ? -96.86059  -5.00429  -102.80340 1.000 17.58944 ? 129 TRP B CZ2 1 
ATOM   3769 C CZ3 . TRP B 1 129 ? -96.27682  -5.86257  -100.59891 1.000 18.40833 ? 129 TRP B CZ3 1 
ATOM   3770 C CH2 . TRP B 1 129 ? -96.50919  -4.78619  -101.49140 1.000 20.10570 ? 129 TRP B CH2 1 
ATOM   3771 N N   . ASP B 1 130 ? -94.67359  -11.04825 -100.32663 1.000 24.22930 ? 130 ASP B N   1 
ATOM   3772 C CA  . ASP B 1 130 ? -94.75265  -11.73853 -99.04639  1.000 21.38740 ? 130 ASP B CA  1 
ATOM   3773 C C   . ASP B 1 130 ? -96.13715  -11.46509 -98.46715  1.000 26.19818 ? 130 ASP B C   1 
ATOM   3774 O O   . ASP B 1 130 ? -96.32621  -10.46251 -97.77320  1.000 25.34846 ? 130 ASP B O   1 
ATOM   3775 C CB  . ASP B 1 130 ? -93.66568  -11.25202 -98.08582  1.000 20.38295 ? 130 ASP B CB  1 
ATOM   3776 C CG  . ASP B 1 130 ? -92.25484  -11.71529 -98.47387  1.000 26.56977 ? 130 ASP B CG  1 
ATOM   3777 O OD1 . ASP B 1 130 ? -92.09708  -12.70024 -99.23946  1.000 20.21839 ? 130 ASP B OD1 1 
ATOM   3778 O OD2 . ASP B 1 130 ? -91.28858  -11.05926 -98.00460  1.000 25.75845 ? 130 ASP B OD2 1 
ATOM   3779 N N   . VAL B 1 131 ? -97.11670  -12.32530 -98.75415  1.000 20.98887 ? 131 VAL B N   1 
ATOM   3780 C CA  . VAL B 1 131 ? -98.49594  -12.01506 -98.38136  1.000 21.22164 ? 131 VAL B CA  1 
ATOM   3781 C C   . VAL B 1 131 ? -98.69710  -12.16936 -96.88210  1.000 26.97655 ? 131 VAL B C   1 
ATOM   3782 O O   . VAL B 1 131 ? -99.23465  -11.27043 -96.22354  1.000 25.64656 ? 131 VAL B O   1 
ATOM   3783 C CB  . VAL B 1 131 ? -99.48639  -12.89255 -99.17217  1.000 26.46348 ? 131 VAL B CB  1 
ATOM   3784 C CG1 . VAL B 1 131 ? -100.94248 -12.65192 -98.68964  1.000 22.32986 ? 131 VAL B CG1 1 
ATOM   3785 C CG2 . VAL B 1 131 ? -99.35152  -12.62331 -100.65320 1.000 20.30961 ? 131 VAL B CG2 1 
ATOM   3786 N N   . ILE B 1 132 ? -98.28440  -13.31160 -96.32620  1.000 27.25850 ? 132 ILE B N   1 
ATOM   3787 C CA  . ILE B 1 132 ? -98.35492  -13.58123 -94.89319  1.000 22.68405 ? 132 ILE B CA  1 
ATOM   3788 C C   . ILE B 1 132 ? -96.92729  -13.65216 -94.36642  1.000 30.22663 ? 132 ILE B C   1 
ATOM   3789 O O   . ILE B 1 132 ? -96.08569  -14.35402 -94.93977  1.000 23.81405 ? 132 ILE B O   1 
ATOM   3790 C CB  . ILE B 1 132 ? -99.12524  -14.87920 -94.59131  1.000 21.46084 ? 132 ILE B CB  1 
ATOM   3791 C CG1 . ILE B 1 132 ? -100.62283 -14.68243 -94.87226  1.000 26.24775 ? 132 ILE B CG1 1 
ATOM   3792 C CG2 . ILE B 1 132 ? -98.95990  -15.28072 -93.12507  1.000 22.04041 ? 132 ILE B CG2 1 
ATOM   3793 C CD1 . ILE B 1 132 ? -101.33131 -13.83240 -93.81833  1.000 23.07715 ? 132 ILE B CD1 1 
ATOM   3794 N N   . ASN B 1 133 ? -96.65004  -12.92180 -93.28441  1.000 25.28285 ? 133 ASN B N   1 
ATOM   3795 C CA  . ASN B 1 133 ? -95.31539  -12.86643 -92.69977  1.000 24.77562 ? 133 ASN B CA  1 
ATOM   3796 C C   . ASN B 1 133 ? -95.31398  -13.44257 -91.28459  1.000 29.24100 ? 133 ASN B C   1 
ATOM   3797 O O   . ASN B 1 133 ? -96.03142  -12.94832 -90.40582  1.000 29.53457 ? 133 ASN B O   1 
ATOM   3798 C CB  . ASN B 1 133 ? -94.79785  -11.43096 -92.67890  1.000 26.26499 ? 133 ASN B CB  1 
ATOM   3799 C CG  . ASN B 1 133 ? -93.29838  -11.37519 -92.57367  1.000 24.80032 ? 133 ASN B CG  1 
ATOM   3800 O OD1 . ASN B 1 133 ? -92.59507  -12.18633 -93.18255  1.000 27.04625 ? 133 ASN B OD1 1 
ATOM   3801 N ND2 . ASN B 1 133 ? -92.79726  -10.45316 -91.76374  1.000 21.66356 ? 133 ASN B ND2 1 
ATOM   3802 N N   . GLU B 1 134 ? -94.51356  -14.48850 -91.06934  1.000 26.58069 ? 134 GLU B N   1 
ATOM   3803 C CA  . GLU B 1 134 ? -94.11811  -14.92117 -89.72341  1.000 26.70982 ? 134 GLU B CA  1 
ATOM   3804 C C   . GLU B 1 134 ? -95.32331  -15.29340 -88.85079  1.000 30.67274 ? 134 GLU B C   1 
ATOM   3805 O O   . GLU B 1 134 ? -95.44932  -14.84649 -87.70485  1.000 30.58527 ? 134 GLU B O   1 
ATOM   3806 C CB  . GLU B 1 134 ? -93.26339  -13.83894 -89.03895  1.000 21.92108 ? 134 GLU B CB  1 
ATOM   3807 C CG  . GLU B 1 134 ? -92.00507  -13.45905 -89.78486  1.000 22.79854 ? 134 GLU B CG  1 
ATOM   3808 C CD  . GLU B 1 134 ? -91.24321  -12.31844 -89.12045  1.000 25.72292 ? 134 GLU B CD  1 
ATOM   3809 O OE1 . GLU B 1 134 ? -91.66185  -11.87854 -88.03411  1.000 31.37065 ? 134 GLU B OE1 1 
ATOM   3810 O OE2 . GLU B 1 134 ? -90.22181  -11.85916 -89.67987  1.000 20.40842 ? 134 GLU B OE2 1 
ATOM   3811 N N   . ALA B 1 135 ? -96.20941  -16.13784 -89.39040  1.000 34.34513 ? 135 ALA B N   1 
ATOM   3812 C CA  . ALA B 1 135 ? -97.41085  -16.54539 -88.66146  1.000 31.79578 ? 135 ALA B CA  1 
ATOM   3813 C C   . ALA B 1 135 ? -97.19493  -17.73524 -87.73477  1.000 35.62361 ? 135 ALA B C   1 
ATOM   3814 O O   . ALA B 1 135 ? -98.00316  -17.93811 -86.82271  1.000 34.22938 ? 135 ALA B O   1 
ATOM   3815 C CB  . ALA B 1 135 ? -98.53913  -16.89558 -89.63562  1.000 30.21373 ? 135 ALA B CB  1 
ATOM   3816 N N   . VAL B 1 136 ? -96.14152  -18.52893 -87.95037  1.000 34.34777 ? 136 VAL B N   1 
ATOM   3817 C CA  . VAL B 1 136 ? -95.87031  -19.71247 -87.13793  1.000 31.50818 ? 136 VAL B CA  1 
ATOM   3818 C C   . VAL B 1 136 ? -95.26352  -19.29269 -85.80155  1.000 37.01560 ? 136 VAL B C   1 
ATOM   3819 O O   . VAL B 1 136 ? -94.48982  -18.32568 -85.73031  1.000 35.61634 ? 136 VAL B O   1 
ATOM   3820 C CB  . VAL B 1 136 ? -94.95211  -20.66817 -87.92266  1.000 39.69760 ? 136 VAL B CB  1 
ATOM   3821 C CG1 . VAL B 1 136 ? -94.35005  -21.75864 -87.02755  1.000 40.68062 ? 136 VAL B CG1 1 
ATOM   3822 C CG2 . VAL B 1 136 ? -95.72822  -21.27645 -89.09331  1.000 35.55780 ? 136 VAL B CG2 1 
ATOM   3823 N N   . ALA B 1 137 ? -95.62129  -20.00716 -84.72886  1.000 34.03791 ? 137 ALA B N   1 
ATOM   3824 C CA  . ALA B 1 137 ? -95.15022  -19.63939 -83.39652  1.000 37.31787 ? 137 ALA B CA  1 
ATOM   3825 C C   . ALA B 1 137 ? -93.67335  -19.99358 -83.21214  1.000 37.91304 ? 137 ALA B C   1 
ATOM   3826 O O   . ALA B 1 137 ? -93.09729  -20.80491 -83.94310  1.000 36.02365 ? 137 ALA B O   1 
ATOM   3827 C CB  . ALA B 1 137 ? -95.98159  -20.32739 -82.31962  1.000 39.40502 ? 137 ALA B CB  1 
ATOM   3828 N N   . ASP B 1 138 ? -93.05691  -19.37783 -82.20320  1.000 43.11430 ? 138 ASP B N   1 
ATOM   3829 C CA  . ASP B 1 138 ? -91.61805  -19.55932 -82.00623  1.000 42.72299 ? 138 ASP B CA  1 
ATOM   3830 C C   . ASP B 1 138 ? -91.30433  -20.84315 -81.23355  1.000 46.38001 ? 138 ASP B C   1 
ATOM   3831 O O   . ASP B 1 138 ? -90.39636  -21.59077 -81.60571  1.000 48.23311 ? 138 ASP B O   1 
ATOM   3832 C CB  . ASP B 1 138 ? -91.03326  -18.33385 -81.29949  1.000 38.43072 ? 138 ASP B CB  1 
ATOM   3833 C CG  . ASP B 1 138 ? -90.87487  -17.12263 -82.23812  1.000 45.91652 ? 138 ASP B CG  1 
ATOM   3834 O OD1 . ASP B 1 138 ? -89.98568  -17.15053 -83.12965  1.000 37.96956 ? 138 ASP B OD1 1 
ATOM   3835 O OD2 . ASP B 1 138 ? -91.65024  -16.14418 -82.07962  1.000 41.65636 ? 138 ASP B OD2 1 
ATOM   3836 N N   . GLU B 1 139 ? -92.03888  -21.12032 -80.15913  1.000 50.95395 ? 139 GLU B N   1 
ATOM   3837 C CA  . GLU B 1 139 ? -91.87370  -22.35256 -79.40042  1.000 57.54771 ? 139 GLU B CA  1 
ATOM   3838 C C   . GLU B 1 139 ? -93.24961  -22.94112 -79.13630  1.000 54.29234 ? 139 GLU B C   1 
ATOM   3839 O O   . GLU B 1 139 ? -94.27870  -22.31218 -79.39981  1.000 54.70612 ? 139 GLU B O   1 
ATOM   3840 C CB  . GLU B 1 139 ? -91.11095  -22.12479 -78.08196  1.000 53.22292 ? 139 GLU B CB  1 
ATOM   3841 C CG  . GLU B 1 139 ? -90.06765  -23.21791 -77.75121  1.000 72.63652 ? 139 GLU B CG  1 
ATOM   3842 C CD  . GLU B 1 139 ? -88.68880  -22.97296 -78.39415  1.000 80.45417 ? 139 GLU B CD  1 
ATOM   3843 O OE1 . GLU B 1 139 ? -88.25411  -23.83108 -79.19430  1.000 83.81170 ? 139 GLU B OE1 1 
ATOM   3844 O OE2 . GLU B 1 139 ? -88.03370  -21.94189 -78.10284  1.000 68.90652 ? 139 GLU B OE2 1 
ATOM   3845 N N   . GLY B 1 140 ? -93.25569  -24.17844 -78.66233  1.000 53.86499 ? 140 GLY B N   1 
ATOM   3846 C CA  . GLY B 1 140 ? -94.47086  -24.82915 -78.21380  1.000 61.88017 ? 140 GLY B CA  1 
ATOM   3847 C C   . GLY B 1 140 ? -95.01182  -25.81933 -79.22873  1.000 64.27652 ? 140 GLY B C   1 
ATOM   3848 O O   . GLY B 1 140 ? -94.36298  -26.17080 -80.21812  1.000 58.43188 ? 140 GLY B O   1 
ATOM   3849 N N   . ASN B 1 141 ? -96.23800  -26.28128 -78.95006  1.000 58.13588 ? 141 ASN B N   1 
ATOM   3850 C CA  . ASN B 1 141 ? -96.89541  -27.27579 -79.77722  1.000 62.79910 ? 141 ASN B CA  1 
ATOM   3851 C C   . ASN B 1 141 ? -97.90613  -26.68949 -80.74592  1.000 60.38513 ? 141 ASN B C   1 
ATOM   3852 O O   . ASN B 1 141 ? -98.28866  -27.37355 -81.70447  1.000 59.86641 ? 141 ASN B O   1 
ATOM   3853 C CB  . ASN B 1 141 ? -97.58929  -28.32778 -78.89140  1.000 72.15929 ? 141 ASN B CB  1 
ATOM   3854 C CG  . ASN B 1 141 ? -96.71249  -29.56722 -78.66981  1.000 73.67206 ? 141 ASN B CG  1 
ATOM   3855 O OD1 . ASN B 1 141 ? -95.51477  -29.44623 -78.33505  1.000 63.99755 ? 141 ASN B OD1 1 
ATOM   3856 N ND2 . ASN B 1 141 ? -97.29313  -30.76605 -78.88393  1.000 70.87503 ? 141 ASN B ND2 1 
ATOM   3857 N N   . GLU B 1 142 ? -98.32590  -25.44230 -80.54488  1.000 58.91931 ? 142 GLU B N   1 
ATOM   3858 C CA  . GLU B 1 142 ? -99.31194  -24.86447 -81.44124  1.000 58.16991 ? 142 GLU B CA  1 
ATOM   3859 C C   . GLU B 1 142 ? -98.64198  -24.39977 -82.73179  1.000 51.89714 ? 142 GLU B C   1 
ATOM   3860 O O   . GLU B 1 142 ? -97.49631  -23.95381 -82.73200  1.000 49.61371 ? 142 GLU B O   1 
ATOM   3861 C CB  . GLU B 1 142 ? -100.03230 -23.70560 -80.75848  1.000 58.50898 ? 142 GLU B CB  1 
ATOM   3862 C CG  . GLU B 1 142 ? -101.00879 -24.10534 -79.62790  1.000 68.01282 ? 142 GLU B CG  1 
ATOM   3863 C CD  . GLU B 1 142 ? -100.37353 -25.00584 -78.53128  1.000 85.21590 ? 142 GLU B CD  1 
ATOM   3864 O OE1 . GLU B 1 142 ? -100.83710 -26.18069 -78.39606  1.000 79.22924 ? 142 GLU B OE1 1 
ATOM   3865 O OE2 . GLU B 1 142 ? -99.38978  -24.56900 -77.84356  1.000 83.61369 ? 142 GLU B OE2 1 
ATOM   3866 N N   . LEU B 1 143 ? -99.35524  -24.54971 -83.84353  1.000 45.37993 ? 143 LEU B N   1 
ATOM   3867 C CA  . LEU B 1 143 ? -98.83115  -24.15786 -85.14396  1.000 44.84355 ? 143 LEU B CA  1 
ATOM   3868 C C   . LEU B 1 143 ? -98.59293  -22.65863 -85.23070  1.000 46.75502 ? 143 LEU B C   1 
ATOM   3869 O O   . LEU B 1 143 ? -97.50942  -22.21283 -85.63705  1.000 48.87603 ? 143 LEU B O   1 
ATOM   3870 C CB  . LEU B 1 143 ? -99.81864  -24.60030 -86.21667  1.000 43.12326 ? 143 LEU B CB  1 
ATOM   3871 C CG  . LEU B 1 143 ? -99.38909  -24.50700 -87.67364  1.000 43.81885 ? 143 LEU B CG  1 
ATOM   3872 C CD1 . LEU B 1 143 ? -98.12208  -25.27998 -87.91806  1.000 39.44527 ? 143 LEU B CD1 1 
ATOM   3873 C CD2 . LEU B 1 143 ? -100.51929 -24.99077 -88.56171  1.000 45.08860 ? 143 LEU B CD2 1 
ATOM   3874 N N   . LEU B 1 144 ? -99.59356  -21.86481 -84.84742  1.000 47.90606 ? 144 LEU B N   1 
ATOM   3875 C CA  . LEU B 1 144 ? -99.63140  -20.43689 -85.09804  1.000 40.10215 ? 144 LEU B CA  1 
ATOM   3876 C C   . LEU B 1 144 ? -99.36194  -19.63243 -83.83631  1.000 34.66334 ? 144 LEU B C   1 
ATOM   3877 O O   . LEU B 1 144 ? -99.71640  -20.03540 -82.72776  1.000 35.75481 ? 144 LEU B O   1 
ATOM   3878 C CB  . LEU B 1 144 ? -100.98781 -20.02377 -85.66488  1.000 41.59977 ? 144 LEU B CB  1 
ATOM   3879 C CG  . LEU B 1 144 ? -101.41939 -20.73430 -86.94537  1.000 39.81616 ? 144 LEU B CG  1 
ATOM   3880 C CD1 . LEU B 1 144 ? -102.77307 -20.22194 -87.39608  1.000 38.41455 ? 144 LEU B CD1 1 
ATOM   3881 C CD2 . LEU B 1 144 ? -100.37419 -20.57557 -88.04951  1.000 35.82038 ? 144 LEU B CD2 1 
ATOM   3882 N N   . ARG B 1 145 ? -98.75309  -18.47588 -84.02173  1.000 33.45371 ? 145 ARG B N   1 
ATOM   3883 C CA  . ARG B 1 145 ? -98.65626  -17.55153 -82.90871  1.000 33.43712 ? 145 ARG B CA  1 
ATOM   3884 C C   . ARG B 1 145 ? -99.94800  -16.74957 -82.79778  1.000 37.10938 ? 145 ARG B C   1 
ATOM   3885 O O   . ARG B 1 145 ? -100.63243 -16.51607 -83.79717  1.000 37.03260 ? 145 ARG B O   1 
ATOM   3886 C CB  . ARG B 1 145 ? -97.47187  -16.60390 -83.09232  1.000 31.46022 ? 145 ARG B CB  1 
ATOM   3887 C CG  . ARG B 1 145 ? -97.64713  -15.59807 -84.22882  1.000 32.50073 ? 145 ARG B CG  1 
ATOM   3888 C CD  . ARG B 1 145 ? -96.57819  -14.51031 -84.19832  1.000 29.42520 ? 145 ARG B CD  1 
ATOM   3889 N NE  . ARG B 1 145 ? -95.31936  -14.96506 -84.79046  1.000 35.10815 ? 145 ARG B NE  1 
ATOM   3890 C CZ  . ARG B 1 145 ? -94.16590  -15.08545 -84.12979  1.000 34.19286 ? 145 ARG B CZ  1 
ATOM   3891 N NH1 . ARG B 1 145 ? -94.09178  -14.78886 -82.83750  1.000 28.18397 ? 145 ARG B NH1 1 
ATOM   3892 N NH2 . ARG B 1 145 ? -93.08127  -15.51333 -84.76829  1.000 29.81948 ? 145 ARG B NH2 1 
ATOM   3893 N N   . PRO B 1 146 ? -100.31015 -16.32437 -81.59652  1.000 36.23767 ? 146 PRO B N   1 
ATOM   3894 C CA  . PRO B 1 146 ? -101.44175 -15.40666 -81.47058  1.000 27.18774 ? 146 PRO B CA  1 
ATOM   3895 C C   . PRO B 1 146 ? -101.14815 -14.09309 -82.17432  1.000 35.24597 ? 146 PRO B C   1 
ATOM   3896 O O   . PRO B 1 146 ? -100.01278 -13.61184 -82.19191  1.000 33.55995 ? 146 PRO B O   1 
ATOM   3897 C CB  . PRO B 1 146 ? -101.58067 -15.21619 -79.95757  1.000 31.95026 ? 146 PRO B CB  1 
ATOM   3898 C CG  . PRO B 1 146 ? -100.23742 -15.52622 -79.41550  1.000 32.39029 ? 146 PRO B CG  1 
ATOM   3899 C CD  . PRO B 1 146 ? -99.63522  -16.56127 -80.31177  1.000 31.19412 ? 146 PRO B CD  1 
ATOM   3900 N N   . SER B 1 147 ? -102.18710 -13.52268 -82.77151  1.000 28.27380 ? 147 SER B N   1 
ATOM   3901 C CA  . SER B 1 147 ? -102.09524 -12.22030 -83.41593  1.000 31.71563 ? 147 SER B CA  1 
ATOM   3902 C C   . SER B 1 147 ? -103.49845 -11.64356 -83.48259  1.000 34.39223 ? 147 SER B C   1 
ATOM   3903 O O   . SER B 1 147 ? -104.48800 -12.37773 -83.41669  1.000 31.77370 ? 147 SER B O   1 
ATOM   3904 C CB  . SER B 1 147 ? -101.45799 -12.31325 -84.81694  1.000 29.10336 ? 147 SER B CB  1 
ATOM   3905 O OG  . SER B 1 147 ? -102.36984 -12.76984 -85.79196  1.000 32.44119 ? 147 SER B OG  1 
ATOM   3906 N N   . LYS B 1 148 ? -103.58628 -10.31553 -83.59882  1.000 30.66221 ? 148 LYS B N   1 
ATOM   3907 C CA  . LYS B 1 148 ? -104.90220 -9.70050  -83.68422  1.000 32.01390 ? 148 LYS B CA  1 
ATOM   3908 C C   . LYS B 1 148 ? -105.58337 -10.03666 -85.00351  1.000 34.99364 ? 148 LYS B C   1 
ATOM   3909 O O   . LYS B 1 148 ? -106.79982 -10.24256 -85.02776  1.000 36.43830 ? 148 LYS B O   1 
ATOM   3910 C CB  . LYS B 1 148 ? -104.81406 -8.19334  -83.42889  1.000 31.59426 ? 148 LYS B CB  1 
ATOM   3911 C CG  . LYS B 1 148 ? -104.31429 -7.91996  -82.02542  1.000 31.97842 ? 148 LYS B CG  1 
ATOM   3912 C CD  . LYS B 1 148 ? -104.36505 -6.45859  -81.59491  1.000 41.28385 ? 148 LYS B CD  1 
ATOM   3913 C CE  . LYS B 1 148 ? -103.53000 -5.57967  -82.52245  1.000 52.70262 ? 148 LYS B CE  1 
ATOM   3914 N NZ  . LYS B 1 148 ? -102.83530 -4.35692  -81.94954  1.000 51.05123 ? 148 LYS B NZ  1 
ATOM   3915 N N   . TRP B 1 149 ? -104.81437 -10.16812 -86.09531  1.000 29.11175 ? 149 TRP B N   1 
ATOM   3916 C CA  . TRP B 1 149 ? -105.37664 -10.68686 -87.34042  1.000 32.00381 ? 149 TRP B CA  1 
ATOM   3917 C C   . TRP B 1 149 ? -106.08690 -12.00147 -87.09174  1.000 34.92847 ? 149 TRP B C   1 
ATOM   3918 O O   . TRP B 1 149 ? -107.25180 -12.18495 -87.46200  1.000 34.86857 ? 149 TRP B O   1 
ATOM   3919 C CB  . TRP B 1 149 ? -104.28178 -10.90811 -88.39115  1.000 26.61033 ? 149 TRP B CB  1 
ATOM   3920 C CG  . TRP B 1 149 ? -103.56965 -9.70802  -88.89747  1.000 28.76751 ? 149 TRP B CG  1 
ATOM   3921 C CD1 . TRP B 1 149 ? -102.27977 -9.34846  -88.62626  1.000 27.71743 ? 149 TRP B CD1 1 
ATOM   3922 C CD2 . TRP B 1 149 ? -104.08265 -8.72240  -89.79857  1.000 29.46360 ? 149 TRP B CD2 1 
ATOM   3923 N NE1 . TRP B 1 149 ? -101.96477 -8.19581  -89.29529  1.000 28.63667 ? 149 TRP B NE1 1 
ATOM   3924 C CE2 . TRP B 1 149 ? -103.05463 -7.78706  -90.02003  1.000 21.53808 ? 149 TRP B CE2 1 
ATOM   3925 C CE3 . TRP B 1 149 ? -105.31787 -8.53180  -90.42676  1.000 25.46452 ? 149 TRP B CE3 1 
ATOM   3926 C CZ2 . TRP B 1 149 ? -103.22008 -6.67653  -90.84296  1.000 26.51588 ? 149 TRP B CZ2 1 
ATOM   3927 C CZ3 . TRP B 1 149 ? -105.47552 -7.43162  -91.25541  1.000 23.45647 ? 149 TRP B CZ3 1 
ATOM   3928 C CH2 . TRP B 1 149 ? -104.43548 -6.51875  -91.45412  1.000 28.17544 ? 149 TRP B CH2 1 
ATOM   3929 N N   . ARG B 1 150 ? -105.38318 -12.93137 -86.44792  1.000 36.07212 ? 150 ARG B N   1 
ATOM   3930 C CA  . ARG B 1 150 ? -105.92253 -14.25953 -86.21024  1.000 32.86090 ? 150 ARG B CA  1 
ATOM   3931 C C   . ARG B 1 150 ? -107.08984 -14.21074 -85.23558  1.000 30.69175 ? 150 ARG B C   1 
ATOM   3932 O O   . ARG B 1 150 ? -108.13542 -14.82359 -85.47455  1.000 35.11103 ? 150 ARG B O   1 
ATOM   3933 C CB  . ARG B 1 150 ? -104.79923 -15.15713 -85.68992  1.000 32.73331 ? 150 ARG B CB  1 
ATOM   3934 C CG  . ARG B 1 150 ? -105.20392 -16.58696 -85.40555  1.000 36.95194 ? 150 ARG B CG  1 
ATOM   3935 C CD  . ARG B 1 150 ? -104.02379 -17.38928 -84.86909  1.000 40.25464 ? 150 ARG B CD  1 
ATOM   3936 N NE  . ARG B 1 150 ? -104.44639 -18.71107 -84.42123  1.000 42.26423 ? 150 ARG B NE  1 
ATOM   3937 C CZ  . ARG B 1 150 ? -103.87099 -19.38214 -83.43042  1.000 48.29574 ? 150 ARG B CZ  1 
ATOM   3938 N NH1 . ARG B 1 150 ? -102.84011 -18.85776 -82.77224  1.000 39.92474 ? 150 ARG B NH1 1 
ATOM   3939 N NH2 . ARG B 1 150 ? -104.33370 -20.57721 -83.09419  1.000 40.81974 ? 150 ARG B NH2 1 
ATOM   3940 N N   . GLN B 1 151 ? -106.93704 -13.45795 -84.14828  1.000 28.62136 ? 151 GLN B N   1 
ATOM   3941 C CA  . GLN B 1 151 ? -107.92167 -13.47087 -83.07505  1.000 27.46366 ? 151 GLN B CA  1 
ATOM   3942 C C   . GLN B 1 151 ? -109.27637 -12.97776 -83.55929  1.000 39.52323 ? 151 GLN B C   1 
ATOM   3943 O O   . GLN B 1 151 ? -110.32233 -13.47229 -83.12029  1.000 37.84905 ? 151 GLN B O   1 
ATOM   3944 C CB  . GLN B 1 151 ? -107.40857 -12.60888 -81.92229  1.000 35.53021 ? 151 GLN B CB  1 
ATOM   3945 C CG  . GLN B 1 151 ? -108.41323 -12.20129 -80.85576  1.000 39.48974 ? 151 GLN B CG  1 
ATOM   3946 C CD  . GLN B 1 151 ? -107.89407 -11.01568 -80.04141  1.000 47.09449 ? 151 GLN B CD  1 
ATOM   3947 O OE1 . GLN B 1 151 ? -106.75774 -11.02803 -79.56360  1.000 57.94652 ? 151 GLN B OE1 1 
ATOM   3948 N NE2 . GLN B 1 151 ? -108.71448 -9.98042  -79.90190  1.000 50.24861 ? 151 GLN B NE2 1 
ATOM   3949 N N   . ILE B 1 152 ? -109.27396 -12.00339 -84.46068  1.000 30.76470 ? 152 ILE B N   1 
ATOM   3950 C CA  . ILE B 1 152 ? -110.50049 -11.38121 -84.91462  1.000 31.26780 ? 152 ILE B CA  1 
ATOM   3951 C C   . ILE B 1 152 ? -111.10214 -12.13576 -86.09065  1.000 38.83608 ? 152 ILE B C   1 
ATOM   3952 O O   . ILE B 1 152 ? -112.29417 -12.45832 -86.07674  1.000 36.51715 ? 152 ILE B O   1 
ATOM   3953 C CB  . ILE B 1 152 ? -110.22822 -9.90592  -85.25359  1.000 31.78734 ? 152 ILE B CB  1 
ATOM   3954 C CG1 . ILE B 1 152 ? -110.05655 -9.10638  -83.96594  1.000 22.40222 ? 152 ILE B CG1 1 
ATOM   3955 C CG2 . ILE B 1 152 ? -111.33303 -9.33643  -86.13253  1.000 29.99423 ? 152 ILE B CG2 1 
ATOM   3956 C CD1 . ILE B 1 152 ? -109.60778 -7.67437  -84.20463  1.000 30.47930 ? 152 ILE B CD1 1 
ATOM   3957 N N   . ILE B 1 153 ? -110.28751 -12.45455 -87.10388  1.000 32.38180 ? 153 ILE B N   1 
ATOM   3958 C CA  . ILE B 1 153 ? -110.79728 -13.13185 -88.29443  1.000 28.86967 ? 153 ILE B CA  1 
ATOM   3959 C C   . ILE B 1 153 ? -111.01673 -14.61922 -88.03702  1.000 38.54929 ? 153 ILE B C   1 
ATOM   3960 O O   . ILE B 1 153 ? -112.03645 -15.18296 -88.44862  1.000 43.07945 ? 153 ILE B O   1 
ATOM   3961 C CB  . ILE B 1 153 ? -109.85260 -12.90901 -89.48923  1.000 31.47798 ? 153 ILE B CB  1 
ATOM   3962 C CG1 . ILE B 1 153 ? -109.86812 -11.45658 -89.95847  1.000 40.16913 ? 153 ILE B CG1 1 
ATOM   3963 C CG2 . ILE B 1 153 ? -110.23460 -13.78269 -90.63570  1.000 30.02878 ? 153 ILE B CG2 1 
ATOM   3964 C CD1 . ILE B 1 153 ? -108.70487 -11.12744 -90.90407  1.000 31.03986 ? 153 ILE B CD1 1 
ATOM   3965 N N   . GLY B 1 154 ? -110.08137 -15.27638 -87.36791  1.000 34.07637 ? 154 GLY B N   1 
ATOM   3966 C CA  . GLY B 1 154 ? -110.05301 -16.72213 -87.28301  1.000 34.76900 ? 154 GLY B CA  1 
ATOM   3967 C C   . GLY B 1 154 ? -108.85739 -17.29922 -88.02305  1.000 39.14871 ? 154 GLY B C   1 
ATOM   3968 O O   . GLY B 1 154 ? -108.09345 -16.59641 -88.68544  1.000 39.51315 ? 154 GLY B O   1 
ATOM   3969 N N   . ASP B 1 155 ? -108.70434 -18.62273 -87.90494  1.000 40.86327 ? 155 ASP B N   1 
ATOM   3970 C CA  . ASP B 1 155 ? -107.48505 -19.24901 -88.41310  1.000 42.51652 ? 155 ASP B CA  1 
ATOM   3971 C C   . ASP B 1 155 ? -107.40967 -19.22236 -89.93434  1.000 42.21611 ? 155 ASP B C   1 
ATOM   3972 O O   . ASP B 1 155 ? -106.32600 -19.43907 -90.50150  1.000 37.55743 ? 155 ASP B O   1 
ATOM   3973 C CB  . ASP B 1 155 ? -107.34164 -20.68969 -87.89963  1.000 42.35230 ? 155 ASP B CB  1 
ATOM   3974 C CG  . ASP B 1 155 ? -106.86835 -20.75707 -86.43518  1.000 46.15340 ? 155 ASP B CG  1 
ATOM   3975 O OD1 . ASP B 1 155 ? -106.63383 -19.69610 -85.81407  1.000 43.71505 ? 155 ASP B OD1 1 
ATOM   3976 O OD2 . ASP B 1 155 ? -106.69374 -21.88016 -85.91153  1.000 52.87274 ? 155 ASP B OD2 1 
ATOM   3977 N N   . ASP B 1 156 ? -108.51645 -18.93374 -90.60625  1.000 32.87806 ? 156 ASP B N   1 
ATOM   3978 C CA  . ASP B 1 156 ? -108.49917 -18.80320 -92.05618  1.000 37.22112 ? 156 ASP B CA  1 
ATOM   3979 C C   . ASP B 1 156 ? -108.07316 -17.41407 -92.52304  1.000 32.00660 ? 156 ASP B C   1 
ATOM   3980 O O   . ASP B 1 156 ? -108.21334 -17.11341 -93.71205  1.000 36.32337 ? 156 ASP B O   1 
ATOM   3981 C CB  . ASP B 1 156 ? -109.87487 -19.15544 -92.62594  1.000 39.07225 ? 156 ASP B CB  1 
ATOM   3982 C CG  . ASP B 1 156 ? -110.92321 -18.12649 -92.28122  1.000 39.68703 ? 156 ASP B CG  1 
ATOM   3983 O OD1 . ASP B 1 156 ? -110.80797 -17.49241 -91.20831  1.000 41.86616 ? 156 ASP B OD1 1 
ATOM   3984 O OD2 . ASP B 1 156 ? -111.87091 -17.96237 -93.07543  1.000 50.94878 ? 156 ASP B OD2 1 
ATOM   3985 N N   . PHE B 1 157 ? -107.54561 -16.56663 -91.63259  1.000 35.59416 ? 157 PHE B N   1 
ATOM   3986 C CA  . PHE B 1 157 ? -107.11136 -15.24039 -92.06485  1.000 31.49972 ? 157 PHE B CA  1 
ATOM   3987 C C   . PHE B 1 157 ? -106.02131 -15.32608 -93.12892  1.000 30.58884 ? 157 PHE B C   1 
ATOM   3988 O O   . PHE B 1 157 ? -105.92652 -14.44399 -93.98731  1.000 32.07077 ? 157 PHE B O   1 
ATOM   3989 C CB  . PHE B 1 157 ? -106.64977 -14.41189 -90.86409  1.000 30.55509 ? 157 PHE B CB  1 
ATOM   3990 C CG  . PHE B 1 157 ? -105.26494 -14.77428 -90.33991  1.000 34.43418 ? 157 PHE B CG  1 
ATOM   3991 C CD1 . PHE B 1 157 ? -105.08605 -15.84941 -89.48073  1.000 30.43693 ? 157 PHE B CD1 1 
ATOM   3992 C CD2 . PHE B 1 157 ? -104.15916 -13.99888 -90.66923  1.000 33.01124 ? 157 PHE B CD2 1 
ATOM   3993 C CE1 . PHE B 1 157 ? -103.82310 -16.17050 -88.99067  1.000 34.04961 ? 157 PHE B CE1 1 
ATOM   3994 C CE2 . PHE B 1 157 ? -102.89180 -14.31197 -90.18054  1.000 36.22796 ? 157 PHE B CE2 1 
ATOM   3995 C CZ  . PHE B 1 157 ? -102.72249 -15.39691 -89.33884  1.000 33.32429 ? 157 PHE B CZ  1 
ATOM   3996 N N   . MET B 1 158 ? -105.22444 -16.39778 -93.12513  1.000 33.48417 ? 158 MET B N   1 
ATOM   3997 C CA  . MET B 1 158 ? -104.17641 -16.52777 -94.13327  1.000 33.35458 ? 158 MET B CA  1 
ATOM   3998 C C   . MET B 1 158 ? -104.75983 -16.90245 -95.48300  1.000 34.21969 ? 158 MET B C   1 
ATOM   3999 O O   . MET B 1 158 ? -104.31468 -16.39044 -96.51747  1.000 30.92781 ? 158 MET B O   1 
ATOM   4000 C CB  . MET B 1 158 ? -103.12941 -17.55665 -93.69282  1.000 26.83370 ? 158 MET B CB  1 
ATOM   4001 C CG  . MET B 1 158 ? -102.30758 -17.09044 -92.51011  1.000 34.20559 ? 158 MET B CG  1 
ATOM   4002 S SD  . MET B 1 158 ? -101.20837 -18.36452 -91.87536  1.000 35.08068 ? 158 MET B SD  1 
ATOM   4003 C CE  . MET B 1 158 ? -102.41680 -19.34295 -90.97306  1.000 38.17184 ? 158 MET B CE  1 
ATOM   4004 N N   . GLU B 1 159 ? -105.73687 -17.81330 -95.49289  1.000 34.25738 ? 159 GLU B N   1 
ATOM   4005 C CA  . GLU B 1 159 ? -106.47107 -18.10591 -96.71876  1.000 39.45700 ? 159 GLU B CA  1 
ATOM   4006 C C   . GLU B 1 159 ? -107.03348 -16.83506 -97.32290  1.000 32.73517 ? 159 GLU B C   1 
ATOM   4007 O O   . GLU B 1 159 ? -106.90129 -16.58961 -98.52660  1.000 29.72020 ? 159 GLU B O   1 
ATOM   4008 C CB  . GLU B 1 159 ? -107.61484 -19.08400 -96.44422  1.000 36.95065 ? 159 GLU B CB  1 
ATOM   4009 C CG  . GLU B 1 159 ? -107.18734 -20.42827 -95.94299  1.000 52.21652 ? 159 GLU B CG  1 
ATOM   4010 C CD  . GLU B 1 159 ? -108.36218 -21.24684 -95.49253  1.000 54.98499 ? 159 GLU B CD  1 
ATOM   4011 O OE1 . GLU B 1 159 ? -109.44462 -21.06923 -96.09332  1.000 47.97354 ? 159 GLU B OE1 1 
ATOM   4012 O OE2 . GLU B 1 159 ? -108.19829 -22.06068 -94.55488  1.000 55.81654 ? 159 GLU B OE2 1 
ATOM   4013 N N   . GLN B 1 160 ? -107.69232 -16.02342 -96.49773  1.000 33.07103 ? 160 GLN B N   1 
ATOM   4014 C CA  . GLN B 1 160 ? -108.31822 -14.81628 -97.01931  1.000 29.64543 ? 160 GLN B CA  1 
ATOM   4015 C C   . GLN B 1 160 ? -107.27375 -13.87981 -97.60380  1.000 35.68433 ? 160 GLN B C   1 
ATOM   4016 O O   . GLN B 1 160 ? -107.48075 -13.30660 -98.67923  1.000 31.94910 ? 160 GLN B O   1 
ATOM   4017 C CB  . GLN B 1 160 ? -109.12816 -14.11794 -95.92435  1.000 29.24586 ? 160 GLN B CB  1 
ATOM   4018 C CG  . GLN B 1 160 ? -110.31935 -14.91807 -95.40584  1.000 37.20191 ? 160 GLN B CG  1 
ATOM   4019 C CD  . GLN B 1 160 ? -111.19755 -15.43729 -96.52940  1.000 36.29281 ? 160 GLN B CD  1 
ATOM   4020 O OE1 . GLN B 1 160 ? -111.60300 -14.69267 -97.42668  1.000 32.49823 ? 160 GLN B OE1 1 
ATOM   4021 N NE2 . GLN B 1 160 ? -111.48162 -16.72991 -96.49280  1.000 45.32652 ? 160 GLN B NE2 1 
ATOM   4022 N N   . ALA B 1 161 ? -106.12541 -13.74462 -96.92688  1.000 29.51017 ? 161 ALA B N   1 
ATOM   4023 C CA  . ALA B 1 161 ? -105.10190 -12.81780 -97.39410  1.000 25.45013 ? 161 ALA B CA  1 
ATOM   4024 C C   . ALA B 1 161 ? -104.57950 -13.22235 -98.76659  1.000 29.40183 ? 161 ALA B C   1 
ATOM   4025 O O   . ALA B 1 161 ? -104.46684 -12.38041 -99.66794  1.000 27.74688 ? 161 ALA B O   1 
ATOM   4026 C CB  . ALA B 1 161 ? -103.96696 -12.73433 -96.37362  1.000 23.71122 ? 161 ALA B CB  1 
ATOM   4027 N N   . PHE B 1 162 ? -104.28463 -14.51172 -98.96019  1.000 26.88675 ? 162 PHE B N   1 
ATOM   4028 C CA  . PHE B 1 162 ? -103.79693 -14.95670 -100.26340 1.000 26.11844 ? 162 PHE B CA  1 
ATOM   4029 C C   . PHE B 1 162 ? -104.85633 -14.76204 -101.35559 1.000 32.32098 ? 162 PHE B C   1 
ATOM   4030 O O   . PHE B 1 162 ? -104.53740 -14.30823 -102.46237 1.000 29.94419 ? 162 PHE B O   1 
ATOM   4031 C CB  . PHE B 1 162 ? -103.32977 -16.41734 -100.18222 1.000 24.46415 ? 162 PHE B CB  1 
ATOM   4032 C CG  . PHE B 1 162 ? -101.92299 -16.58139 -99.63380  1.000 30.33855 ? 162 PHE B CG  1 
ATOM   4033 C CD1 . PHE B 1 162 ? -100.80866 -16.34648 -100.44140 1.000 29.46473 ? 162 PHE B CD1 1 
ATOM   4034 C CD2 . PHE B 1 162 ? -101.71173 -16.96805 -98.30587  1.000 22.41257 ? 162 PHE B CD2 1 
ATOM   4035 C CE1 . PHE B 1 162 ? -99.49837  -16.48339 -99.93201  1.000 26.28771 ? 162 PHE B CE1 1 
ATOM   4036 C CE2 . PHE B 1 162 ? -100.41723 -17.11889 -97.79308  1.000 22.53786 ? 162 PHE B CE2 1 
ATOM   4037 C CZ  . PHE B 1 162 ? -99.31316  -16.87721 -98.60433  1.000 25.32344 ? 162 PHE B CZ  1 
ATOM   4038 N N   . LEU B 1 163 ? -106.12609 -15.06720 -101.06401 1.000 31.68852 ? 163 LEU B N   1 
ATOM   4039 C CA  . LEU B 1 163 ? -107.17093 -14.87543 -102.07380 1.000 28.71505 ? 163 LEU B CA  1 
ATOM   4040 C C   . LEU B 1 163 ? -107.25927 -13.41476 -102.50342 1.000 28.62117 ? 163 LEU B C   1 
ATOM   4041 O O   . LEU B 1 163 ? -107.27736 -13.10548 -103.70135 1.000 24.43125 ? 163 LEU B O   1 
ATOM   4042 C CB  . LEU B 1 163 ? -108.51976 -15.36162 -101.53956 1.000 29.77018 ? 163 LEU B CB  1 
ATOM   4043 C CG  . LEU B 1 163 ? -108.58864 -16.86784 -101.27700 1.000 35.78477 ? 163 LEU B CG  1 
ATOM   4044 C CD1 . LEU B 1 163 ? -109.77312 -17.20547 -100.37811 1.000 30.82652 ? 163 LEU B CD1 1 
ATOM   4045 C CD2 . LEU B 1 163 ? -108.64351 -17.63810 -102.60275 1.000 26.14722 ? 163 LEU B CD2 1 
ATOM   4046 N N   . TYR B 1 164 ? -107.28724 -12.49680 -101.53452 1.000 25.38295 ? 164 TYR B N   1 
ATOM   4047 C CA  . TYR B 1 164 ? -107.34025 -11.07609 -101.86990 1.000 27.16206 ? 164 TYR B CA  1 
ATOM   4048 C C   . TYR B 1 164 ? -106.12777 -10.65019 -102.69133 1.000 30.30995 ? 164 TYR B C   1 
ATOM   4049 O O   . TYR B 1 164 ? -106.25905 -9.85776  -103.63139 1.000 28.91541 ? 164 TYR B O   1 
ATOM   4050 C CB  . TYR B 1 164 ? -107.43681 -10.23010 -100.59873 1.000 27.05757 ? 164 TYR B CB  1 
ATOM   4051 C CG  . TYR B 1 164 ? -108.64112 -10.51776 -99.72620  1.000 33.68755 ? 164 TYR B CG  1 
ATOM   4052 C CD1 . TYR B 1 164 ? -109.88248 -10.82325 -100.28480 1.000 36.33452 ? 164 TYR B CD1 1 
ATOM   4053 C CD2 . TYR B 1 164 ? -108.53307 -10.48790 -98.34020  1.000 30.14746 ? 164 TYR B CD2 1 
ATOM   4054 C CE1 . TYR B 1 164 ? -110.97573 -11.07965 -99.48339  1.000 36.36408 ? 164 TYR B CE1 1 
ATOM   4055 C CE2 . TYR B 1 164 ? -109.61526 -10.74852 -97.53736  1.000 31.32971 ? 164 TYR B CE2 1 
ATOM   4056 C CZ  . TYR B 1 164 ? -110.83154 -11.04488 -98.10867  1.000 38.00786 ? 164 TYR B CZ  1 
ATOM   4057 O OH  . TYR B 1 164 ? -111.90307 -11.30679 -97.30129  1.000 34.28446 ? 164 TYR B OH  1 
ATOM   4058 N N   . ALA B 1 165 ? -104.93146 -11.14663 -102.34418 1.000 26.58544 ? 165 ALA B N   1 
ATOM   4059 C CA  . ALA B 1 165 ? -103.74720 -10.78972 -103.12386 1.000 33.18530 ? 165 ALA B CA  1 
ATOM   4060 C C   . ALA B 1 165 ? -103.85832 -11.32758 -104.54682 1.000 27.73160 ? 165 ALA B C   1 
ATOM   4061 O O   . ALA B 1 165 ? -103.64266 -10.59348 -105.51917 1.000 28.51952 ? 165 ALA B O   1 
ATOM   4062 C CB  . ALA B 1 165 ? -102.47338 -11.30954 -102.44128 1.000 22.88789 ? 165 ALA B CB  1 
ATOM   4063 N N   . TYR B 1 166 ? -104.22602 -12.60581 -104.68339 1.000 31.74500 ? 166 TYR B N   1 
ATOM   4064 C CA  . TYR B 1 166 ? -104.41467 -13.21173 -106.00134 1.000 33.03523 ? 166 TYR B CA  1 
ATOM   4065 C C   . TYR B 1 166 ? -105.41397 -12.42040 -106.83683 1.000 33.12131 ? 166 TYR B C   1 
ATOM   4066 O O   . TYR B 1 166 ? -105.16064 -12.11647 -108.00784 1.000 32.68532 ? 166 TYR B O   1 
ATOM   4067 C CB  . TYR B 1 166 ? -104.88186 -14.65471 -105.83748 1.000 28.81731 ? 166 TYR B CB  1 
ATOM   4068 C CG  . TYR B 1 166 ? -105.14380 -15.40367 -107.12888 1.000 38.80652 ? 166 TYR B CG  1 
ATOM   4069 C CD1 . TYR B 1 166 ? -104.10173 -15.73825 -107.99272 1.000 32.50466 ? 166 TYR B CD1 1 
ATOM   4070 C CD2 . TYR B 1 166 ? -106.44251 -15.80088 -107.47718 1.000 34.41610 ? 166 TYR B CD2 1 
ATOM   4071 C CE1 . TYR B 1 166 ? -104.34486 -16.45081 -109.17313 1.000 35.61007 ? 166 TYR B CE1 1 
ATOM   4072 C CE2 . TYR B 1 166 ? -106.69297 -16.50778 -108.65571 1.000 24.59799 ? 166 TYR B CE2 1 
ATOM   4073 C CZ  . TYR B 1 166 ? -105.64822 -16.83059 -109.49248 1.000 33.50558 ? 166 TYR B CZ  1 
ATOM   4074 O OH  . TYR B 1 166 ? -105.90895 -17.53067 -110.64848 1.000 37.75652 ? 166 TYR B OH  1 
ATOM   4075 N N   . GLU B 1 167 ? -106.55016 -12.06197 -106.23917 1.000 29.99366 ? 167 GLU B N   1 
ATOM   4076 C CA  . GLU B 1 167 ? -107.55804 -11.29273 -106.96143 1.000 34.41484 ? 167 GLU B CA  1 
ATOM   4077 C C   . GLU B 1 167 ? -106.99877 -9.96127  -107.45443 1.000 36.60449 ? 167 GLU B C   1 
ATOM   4078 O O   . GLU B 1 167 ? -107.32033 -9.51982  -108.56389 1.000 36.86777 ? 167 GLU B O   1 
ATOM   4079 C CB  . GLU B 1 167 ? -108.77609 -11.08319 -106.06272 1.000 37.86250 ? 167 GLU B CB  1 
ATOM   4080 C CG  . GLU B 1 167 ? -109.73601 -9.99888  -106.52113 1.000 46.97979 ? 167 GLU B CG  1 
ATOM   4081 C CD  . GLU B 1 167 ? -110.99660 -9.93680  -105.66958 1.000 57.71652 ? 167 GLU B CD  1 
ATOM   4082 O OE1 . GLU B 1 167 ? -110.88711 -9.94547  -104.42202 1.000 59.97280 ? 167 GLU B OE1 1 
ATOM   4083 O OE2 . GLU B 1 167 ? -112.10105 -9.87749  -106.24794 1.000 59.82357 ? 167 GLU B OE2 1 
ATOM   4084 N N   . ALA B 1 168 ? -106.14199 -9.31297  -106.65589 1.000 37.22144 ? 168 ALA B N   1 
ATOM   4085 C CA  . ALA B 1 168 ? -105.60612 -8.01588  -107.06410 1.000 32.76542 ? 168 ALA B CA  1 
ATOM   4086 C C   . ALA B 1 168 ? -104.60271 -8.14706  -108.20234 1.000 32.46506 ? 168 ALA B C   1 
ATOM   4087 O O   . ALA B 1 168 ? -104.48814 -7.23728  -109.02770 1.000 34.02628 ? 168 ALA B O   1 
ATOM   4088 C CB  . ALA B 1 168 ? -104.95756 -7.30347  -105.87660 1.000 29.85968 ? 168 ALA B CB  1 
ATOM   4089 N N   . ASP B 1 169 ? -103.86565 -9.25320  -108.26417 1.000 27.98018 ? 169 ASP B N   1 
ATOM   4090 C CA  . ASP B 1 169 ? -102.86828 -9.45638  -109.31573 1.000 32.92646 ? 169 ASP B CA  1 
ATOM   4091 C C   . ASP B 1 169 ? -102.63109 -10.94541 -109.49815 1.000 32.51917 ? 169 ASP B C   1 
ATOM   4092 O O   . ASP B 1 169 ? -101.76011 -11.53580 -108.84844 1.000 34.89894 ? 169 ASP B O   1 
ATOM   4093 C CB  . ASP B 1 169 ? -101.55447 -8.74750  -109.00042 1.000 30.18257 ? 169 ASP B CB  1 
ATOM   4094 C CG  . ASP B 1 169 ? -100.54238 -8.90653  -110.10510 1.000 31.01308 ? 169 ASP B CG  1 
ATOM   4095 O OD1 . ASP B 1 169 ? -100.90181 -9.43251  -111.17238 1.000 32.56987 ? 169 ASP B OD1 1 
ATOM   4096 O OD2 . ASP B 1 169 ? -99.37394  -8.53226  -109.90577 1.000 35.93619 ? 169 ASP B OD2 1 
ATOM   4097 N N   . PRO B 1 170 ? -103.36709 -11.58645 -110.40818 1.000 35.30792 ? 170 PRO B N   1 
ATOM   4098 C CA  . PRO B 1 170 ? -103.23925 -13.04512 -110.55067 1.000 33.69879 ? 170 PRO B CA  1 
ATOM   4099 C C   . PRO B 1 170 ? -101.94928 -13.47988 -111.22288 1.000 32.89340 ? 170 PRO B C   1 
ATOM   4100 O O   . PRO B 1 170 ? -101.70798 -14.69448 -111.31922 1.000 35.26901 ? 170 PRO B O   1 
ATOM   4101 C CB  . PRO B 1 170 ? -104.46628 -13.43151 -111.39309 1.000 28.98991 ? 170 PRO B CB  1 
ATOM   4102 C CG  . PRO B 1 170 ? -105.36915 -12.19858 -111.38362 1.000 37.38155 ? 170 PRO B CG  1 
ATOM   4103 C CD  . PRO B 1 170 ? -104.43085 -11.03408 -111.26525 1.000 34.63454 ? 170 PRO B CD  1 
ATOM   4104 N N   . ASP B 1 171 ? -101.12253 -12.54405 -111.70308 1.000 29.09298 ? 171 ASP B N   1 
ATOM   4105 C CA  . ASP B 1 171 ? -99.79905  -12.87416 -112.22572 1.000 35.14682 ? 171 ASP B CA  1 
ATOM   4106 C C   . ASP B 1 171 ? -98.68753  -12.82321 -111.18341 1.000 32.19680 ? 171 ASP B C   1 
ATOM   4107 O O   . ASP B 1 171 ? -97.53588  -13.10505 -111.52665 1.000 37.81150 ? 171 ASP B O   1 
ATOM   4108 C CB  . ASP B 1 171 ? -99.42442  -11.92477 -113.36080 1.000 43.72912 ? 171 ASP B CB  1 
ATOM   4109 C CG  . ASP B 1 171 ? -100.36729 -12.02393 -114.51691 1.000 46.69598 ? 171 ASP B CG  1 
ATOM   4110 O OD1 . ASP B 1 171 ? -100.66260 -13.16624 -114.94720 1.000 50.41380 ? 171 ASP B OD1 1 
ATOM   4111 O OD2 . ASP B 1 171 ? -100.82816 -10.95729 -114.96957 1.000 40.69113 ? 171 ASP B OD2 1 
ATOM   4112 N N   . ALA B 1 172 ? -98.97451  -12.42531 -109.94549 1.000 32.64159 ? 172 ALA B N   1 
ATOM   4113 C CA  . ALA B 1 172 ? -97.92835  -12.29477 -108.94209 1.000 33.89394 ? 172 ALA B CA  1 
ATOM   4114 C C   . ALA B 1 172 ? -97.70578  -13.62911 -108.24583 1.000 31.73888 ? 172 ALA B C   1 
ATOM   4115 O O   . ALA B 1 172 ? -98.65039  -14.39108 -108.02155 1.000 35.67884 ? 172 ALA B O   1 
ATOM   4116 C CB  . ALA B 1 172 ? -98.28634  -11.21825 -107.91982 1.000 26.94352 ? 172 ALA B CB  1 
ATOM   4117 N N   . LEU B 1 173 ? -96.44886  -13.91982 -107.92575 1.000 30.26858 ? 173 LEU B N   1 
ATOM   4118 C CA  . LEU B 1 173 ? -96.14089  -15.06559 -107.08202 1.000 26.68574 ? 173 LEU B CA  1 
ATOM   4119 C C   . LEU B 1 173 ? -96.32562  -14.67738 -105.61424 1.000 31.88587 ? 173 LEU B C   1 
ATOM   4120 O O   . LEU B 1 173 ? -95.72208  -13.70982 -105.13474 1.000 32.67708 ? 173 LEU B O   1 
ATOM   4121 C CB  . LEU B 1 173 ? -94.72117  -15.55885 -107.34277 1.000 33.96276 ? 173 LEU B CB  1 
ATOM   4122 C CG  . LEU B 1 173 ? -94.34483  -15.96193 -108.76494 1.000 34.96129 ? 173 LEU B CG  1 
ATOM   4123 C CD1 . LEU B 1 173 ? -92.92020  -16.43086 -108.76774 1.000 26.63027 ? 173 LEU B CD1 1 
ATOM   4124 C CD2 . LEU B 1 173 ? -95.26921  -17.04147 -109.29021 1.000 28.34151 ? 173 LEU B CD2 1 
ATOM   4125 N N   . LEU B 1 174 ? -97.14370  -15.44133 -104.89741 1.000 28.88461 ? 174 LEU B N   1 
ATOM   4126 C CA  . LEU B 1 174 ? -97.50713  -15.13451 -103.52268 1.000 22.11854 ? 174 LEU B CA  1 
ATOM   4127 C C   . LEU B 1 174 ? -96.76105  -16.06877 -102.57908 1.000 31.59245 ? 174 LEU B C   1 
ATOM   4128 O O   . LEU B 1 174 ? -96.74358  -17.28725 -102.78466 1.000 31.36365 ? 174 LEU B O   1 
ATOM   4129 C CB  . LEU B 1 174 ? -99.02156  -15.25046 -103.32761 1.000 26.52972 ? 174 LEU B CB  1 
ATOM   4130 C CG  . LEU B 1 174 ? -99.87337  -14.48566 -104.35247 1.000 30.92733 ? 174 LEU B CG  1 
ATOM   4131 C CD1 . LEU B 1 174 ? -101.37669 -14.54318 -104.04102 1.000 24.93423 ? 174 LEU B CD1 1 
ATOM   4132 C CD2 . LEU B 1 174 ? -99.40424  -13.04316 -104.44610 1.000 24.03894 ? 174 LEU B CD2 1 
ATOM   4133 N N   . PHE B 1 175 ? -96.16221  -15.49586 -101.53773 1.000 24.98024 ? 175 PHE B N   1 
ATOM   4134 C CA  . PHE B 1 175 ? -95.24191  -16.20623 -100.66721 1.000 25.82709 ? 175 PHE B CA  1 
ATOM   4135 C C   . PHE B 1 175 ? -95.74937  -16.23615 -99.23745  1.000 25.72881 ? 175 PHE B C   1 
ATOM   4136 O O   . PHE B 1 175 ? -96.32983  -15.26174 -98.75074  1.000 23.63879 ? 175 PHE B O   1 
ATOM   4137 C CB  . PHE B 1 175 ? -93.86448  -15.53858 -100.68381 1.000 24.74316 ? 175 PHE B CB  1 
ATOM   4138 C CG  . PHE B 1 175 ? -93.01867  -15.93988 -101.84053 1.000 29.81783 ? 175 PHE B CG  1 
ATOM   4139 C CD1 . PHE B 1 175 ? -93.32662  -15.49880 -103.12611 1.000 29.34280 ? 175 PHE B CD1 1 
ATOM   4140 C CD2 . PHE B 1 175 ? -91.90993  -16.74926 -101.65185 1.000 23.84219 ? 175 PHE B CD2 1 
ATOM   4141 C CE1 . PHE B 1 175 ? -92.54705  -15.86313 -104.20395 1.000 29.10756 ? 175 PHE B CE1 1 
ATOM   4142 C CE2 . PHE B 1 175 ? -91.12363  -17.11570 -102.71755 1.000 29.08770 ? 175 PHE B CE2 1 
ATOM   4143 C CZ  . PHE B 1 175 ? -91.44048  -16.67174 -104.00403 1.000 32.79117 ? 175 PHE B CZ  1 
ATOM   4144 N N   . TYR B 1 176 ? -95.48771  -17.34366 -98.55577  1.000 31.65259 ? 176 TYR B N   1 
ATOM   4145 C CA  . TYR B 1 176 ? -95.38758  -17.34485 -97.10413  1.000 29.28318 ? 176 TYR B CA  1 
ATOM   4146 C C   . TYR B 1 176 ? -93.91466  -17.16440 -96.74057  1.000 26.08509 ? 176 TYR B C   1 
ATOM   4147 O O   . TYR B 1 176 ? -93.05649  -17.86799 -97.27402  1.000 28.65290 ? 176 TYR B O   1 
ATOM   4148 C CB  . TYR B 1 176 ? -95.93485  -18.63885 -96.50048  1.000 25.75372 ? 176 TYR B CB  1 
ATOM   4149 C CG  . TYR B 1 176 ? -95.76513  -18.65367 -94.99915  1.000 33.52959 ? 176 TYR B CG  1 
ATOM   4150 C CD1 . TYR B 1 176 ? -96.75055  -18.11625 -94.18572  1.000 23.58596 ? 176 TYR B CD1 1 
ATOM   4151 C CD2 . TYR B 1 176 ? -94.60511  -19.16511 -94.39112  1.000 25.17900 ? 176 TYR B CD2 1 
ATOM   4152 C CE1 . TYR B 1 176 ? -96.61877  -18.08209 -92.82067  1.000 28.05375 ? 176 TYR B CE1 1 
ATOM   4153 C CE2 . TYR B 1 176 ? -94.45788  -19.12520 -92.99607  1.000 29.53835 ? 176 TYR B CE2 1 
ATOM   4154 C CZ  . TYR B 1 176 ? -95.48036  -18.58312 -92.22009  1.000 31.61144 ? 176 TYR B CZ  1 
ATOM   4155 O OH  . TYR B 1 176 ? -95.40719  -18.52165 -90.83854  1.000 27.45174 ? 176 TYR B OH  1 
ATOM   4156 N N   . ASN B 1 177 ? -93.63074  -16.23421 -95.82721  1.000 27.22743 ? 177 ASN B N   1 
ATOM   4157 C CA  . ASN B 1 177 ? -92.27927  -15.80752 -95.48952  1.000 24.28684 ? 177 ASN B CA  1 
ATOM   4158 C C   . ASN B 1 177 ? -92.09384  -15.93097 -93.97990  1.000 34.14838 ? 177 ASN B C   1 
ATOM   4159 O O   . ASN B 1 177 ? -93.01839  -15.62289 -93.22242  1.000 23.21399 ? 177 ASN B O   1 
ATOM   4160 C CB  . ASN B 1 177 ? -92.05587  -14.35310 -95.97444  1.000 26.00168 ? 177 ASN B CB  1 
ATOM   4161 C CG  . ASN B 1 177 ? -90.60610  -13.87442 -95.82784  1.000 21.03752 ? 177 ASN B CG  1 
ATOM   4162 O OD1 . ASN B 1 177 ? -89.70731  -14.38247 -96.47856  1.000 25.20547 ? 177 ASN B OD1 1 
ATOM   4163 N ND2 . ASN B 1 177 ? -90.40139  -12.84507 -95.01765  1.000 23.50518 ? 177 ASN B ND2 1 
ATOM   4164 N N   . ASP B 1 178 ? -90.91775  -16.40539 -93.54078  1.000 28.06902 ? 178 ASP B N   1 
ATOM   4165 C CA  . ASP B 1 178 ? -90.68657  -16.67012 -92.11689  1.000 26.91594 ? 178 ASP B CA  1 
ATOM   4166 C C   . ASP B 1 178 ? -89.19282  -16.82722 -91.82508  1.000 28.05341 ? 178 ASP B C   1 
ATOM   4167 O O   . ASP B 1 178 ? -88.37702  -17.02117 -92.72956  1.000 25.69214 ? 178 ASP B O   1 
ATOM   4168 C CB  . ASP B 1 178 ? -91.44363  -17.92017 -91.64771  1.000 22.62946 ? 178 ASP B CB  1 
ATOM   4169 C CG  . ASP B 1 178 ? -91.94949  -17.79728 -90.21193  1.000 29.49881 ? 178 ASP B CG  1 
ATOM   4170 O OD1 . ASP B 1 178 ? -91.28809  -17.12191 -89.40714  1.000 22.97295 ? 178 ASP B OD1 1 
ATOM   4171 O OD2 . ASP B 1 178 ? -93.02472  -18.35837 -89.88857  1.000 33.97172 ? 178 ASP B OD2 1 
ATOM   4172 N N   . TYR B 1 179 ? -88.84678  -16.74868 -90.54143  1.000 24.81721 ? 179 TYR B N   1 
ATOM   4173 C CA  . TYR B 1 179 ? -87.47019  -16.90301 -90.07340  1.000 28.79087 ? 179 TYR B CA  1 
ATOM   4174 C C   . TYR B 1 179 ? -87.35121  -18.14512 -89.19009  1.000 28.18294 ? 179 TYR B C   1 
ATOM   4175 O O   . TYR B 1 179 ? -88.34556  -18.76532 -88.81205  1.000 23.85659 ? 179 TYR B O   1 
ATOM   4176 C CB  . TYR B 1 179 ? -87.00749  -15.65563 -89.31061  1.000 23.12002 ? 179 TYR B CB  1 
ATOM   4177 C CG  . TYR B 1 179 ? -87.80054  -15.45617 -88.04656  1.000 30.79395 ? 179 TYR B CG  1 
ATOM   4178 C CD1 . TYR B 1 179 ? -89.01616  -14.78860 -88.07371  1.000 25.12649 ? 179 TYR B CD1 1 
ATOM   4179 C CD2 . TYR B 1 179 ? -87.35580  -15.96101 -86.82763  1.000 31.22675 ? 179 TYR B CD2 1 
ATOM   4180 C CE1 . TYR B 1 179 ? -89.77355  -14.62636 -86.92804  1.000 31.41673 ? 179 TYR B CE1 1 
ATOM   4181 C CE2 . TYR B 1 179 ? -88.10927  -15.79362 -85.66799  1.000 34.84499 ? 179 TYR B CE2 1 
ATOM   4182 C CZ  . TYR B 1 179 ? -89.32089  -15.12842 -85.73018  1.000 30.00980 ? 179 TYR B CZ  1 
ATOM   4183 O OH  . TYR B 1 179 ? -90.07431  -14.95041 -84.59666  1.000 30.67156 ? 179 TYR B OH  1 
ATOM   4184 N N   . ASN B 1 180 ? -86.10640  -18.49490 -88.85562  1.000 29.92837 ? 180 ASN B N   1 
ATOM   4185 C CA  . ASN B 1 180 ? -85.78110  -19.74982 -88.16854  1.000 30.71753 ? 180 ASN B CA  1 
ATOM   4186 C C   . ASN B 1 180 ? -86.37332  -20.94597 -88.89963  1.000 30.44420 ? 180 ASN B C   1 
ATOM   4187 O O   . ASN B 1 180 ? -86.69422  -21.97334 -88.29312  1.000 27.47472 ? 180 ASN B O   1 
ATOM   4188 C CB  . ASN B 1 180 ? -86.21956  -19.72405 -86.70418  1.000 25.81397 ? 180 ASN B CB  1 
ATOM   4189 C CG  . ASN B 1 180 ? -85.33106  -18.82777 -85.86405  1.000 31.67760 ? 180 ASN B CG  1 
ATOM   4190 O OD1 . ASN B 1 180 ? -84.27482  -18.38752 -86.32858  1.000 38.84002 ? 180 ASN B OD1 1 
ATOM   4191 N ND2 . ASN B 1 180 ? -85.74527  -18.54693 -84.63101  1.000 31.79546 ? 180 ASN B ND2 1 
ATOM   4192 N N   . GLU B 1 181 ? -86.47457  -20.81116 -90.22338  1.000 23.95104 ? 181 GLU B N   1 
ATOM   4193 C CA  . GLU B 1 181 ? -87.14810  -21.74650 -91.11742  1.000 27.93787 ? 181 GLU B CA  1 
ATOM   4194 C C   . GLU B 1 181 ? -86.44915  -23.10082 -91.23779  1.000 35.95126 ? 181 GLU B C   1 
ATOM   4195 O O   . GLU B 1 181 ? -87.03859  -24.02160 -91.82328  1.000 39.30213 ? 181 GLU B O   1 
ATOM   4196 C CB  . GLU B 1 181 ? -87.28821  -21.09102 -92.50581  1.000 23.09579 ? 181 GLU B CB  1 
ATOM   4197 C CG  . GLU B 1 181 ? -85.95357  -20.84139 -93.26026  1.000 30.21873 ? 181 GLU B CG  1 
ATOM   4198 C CD  . GLU B 1 181 ? -85.00118  -19.87621 -92.54122  1.000 30.28823 ? 181 GLU B CD  1 
ATOM   4199 O OE1 . GLU B 1 181 ? -85.45747  -18.82012 -92.06417  1.000 35.33236 ? 181 GLU B OE1 1 
ATOM   4200 O OE2 . GLU B 1 181 ? -83.79683  -20.18399 -92.42822  1.000 33.80608 ? 181 GLU B OE2 1 
ATOM   4201 N N   . CYS B 1 182 ? -85.21751  -23.24902 -90.71407  1.000 30.48816 ? 182 CYS B N   1 
ATOM   4202 C CA  . CYS B 1 182 ? -84.45827  -24.49796 -90.81707  1.000 34.83067 ? 182 CYS B CA  1 
ATOM   4203 C C   . CYS B 1 182 ? -84.38447  -25.29187 -89.52352  1.000 34.68363 ? 182 CYS B C   1 
ATOM   4204 O O   . CYS B 1 182 ? -83.94181  -26.44568 -89.54838  1.000 35.23430 ? 182 CYS B O   1 
ATOM   4205 C CB  . CYS B 1 182 ? -83.03272  -24.22381 -91.31467  1.000 29.21933 ? 182 CYS B CB  1 
ATOM   4206 S SG  . CYS B 1 182 ? -83.07640  -23.51889 -92.97767  1.000 30.78098 ? 182 CYS B SG  1 
ATOM   4207 N N   . PHE B 1 183 ? -84.77984  -24.71251 -88.41147  1.000 26.99319 ? 183 PHE B N   1 
ATOM   4208 C CA  . PHE B 1 183 ? -84.82362  -25.46476 -87.17349  1.000 37.10170 ? 183 PHE B CA  1 
ATOM   4209 C C   . PHE B 1 183 ? -85.90306  -26.52813 -87.29687  1.000 47.83620 ? 183 PHE B C   1 
ATOM   4210 O O   . PHE B 1 183 ? -87.03946  -26.20672 -87.68129  1.000 45.23800 ? 183 PHE B O   1 
ATOM   4211 C CB  . PHE B 1 183 ? -85.07200  -24.52245 -86.00175  1.000 40.11275 ? 183 PHE B CB  1 
ATOM   4212 C CG  . PHE B 1 183 ? -83.95091  -23.53894 -85.80727  1.000 50.29089 ? 183 PHE B CG  1 
ATOM   4213 C CD1 . PHE B 1 183 ? -82.65357  -23.89548 -86.16883  1.000 57.81652 ? 183 PHE B CD1 1 
ATOM   4214 C CD2 . PHE B 1 183 ? -84.17019  -22.27422 -85.28772  1.000 50.69173 ? 183 PHE B CD2 1 
ATOM   4215 C CE1 . PHE B 1 183 ? -81.60179  -23.02074 -86.01710  1.000 51.96652 ? 183 PHE B CE1 1 
ATOM   4216 C CE2 . PHE B 1 183 ? -83.10400  -21.38427 -85.13152  1.000 49.99822 ? 183 PHE B CE2 1 
ATOM   4217 C CZ  . PHE B 1 183 ? -81.82473  -21.76219 -85.50029  1.000 51.43479 ? 183 PHE B CZ  1 
ATOM   4218 N N   . PRO B 1 184 ? -85.57901  -27.80068 -87.03792  1.000 45.57826 ? 184 PRO B N   1 
ATOM   4219 C CA  . PRO B 1 184 ? -86.48529  -28.88679 -87.44853  1.000 43.94344 ? 184 PRO B CA  1 
ATOM   4220 C C   . PRO B 1 184 ? -87.90478  -28.73089 -86.92817  1.000 43.29176 ? 184 PRO B C   1 
ATOM   4221 O O   . PRO B 1 184 ? -88.85804  -29.01871 -87.66314  1.000 45.47884 ? 184 PRO B O   1 
ATOM   4222 C CB  . PRO B 1 184 ? -85.79744  -30.14085 -86.89446  1.000 37.02049 ? 184 PRO B CB  1 
ATOM   4223 C CG  . PRO B 1 184 ? -84.35061  -29.77641 -86.78360  1.000 37.13454 ? 184 PRO B CG  1 
ATOM   4224 C CD  . PRO B 1 184 ? -84.26435  -28.29027 -86.57865  1.000 41.65166 ? 184 PRO B CD  1 
ATOM   4225 N N   . GLU B 1 185 ? -88.07829  -28.24980 -85.69660  1.000 39.68948 ? 185 GLU B N   1 
ATOM   4226 C CA  . GLU B 1 185 ? -89.42511  -28.13537 -85.15541  1.000 44.61133 ? 185 GLU B CA  1 
ATOM   4227 C C   . GLU B 1 185 ? -90.22659  -27.08906 -85.92028  1.000 44.02177 ? 185 GLU B C   1 
ATOM   4228 O O   . GLU B 1 185 ? -91.36199  -27.34412 -86.33422  1.000 46.60669 ? 185 GLU B O   1 
ATOM   4229 C CB  . GLU B 1 185 ? -89.36894  -27.81452 -83.65944  1.000 49.21823 ? 185 GLU B CB  1 
ATOM   4230 C CG  . GLU B 1 185 ? -90.51120  -28.45475 -82.86241  1.000 68.54344 ? 185 GLU B CG  1 
ATOM   4231 C CD  . GLU B 1 185 ? -90.84668  -27.72866 -81.55802  1.000 74.51697 ? 185 GLU B CD  1 
ATOM   4232 O OE1 . GLU B 1 185 ? -92.00895  -27.83924 -81.10338  1.000 71.46720 ? 185 GLU B OE1 1 
ATOM   4233 O OE2 . GLU B 1 185 ? -89.95102  -27.07626 -80.97143  1.000 72.13852 ? 185 GLU B OE2 1 
ATOM   4234 N N   . LYS B 1 186 ? -89.63711  -25.91501 -86.14792  1.000 41.13659 ? 186 LYS B N   1 
ATOM   4235 C CA  . LYS B 1 186 ? -90.34672  -24.87056 -86.87739  1.000 39.25401 ? 186 LYS B CA  1 
ATOM   4236 C C   . LYS B 1 186 ? -90.45895  -25.19970 -88.36111  1.000 36.13328 ? 186 LYS B C   1 
ATOM   4237 O O   . LYS B 1 186 ? -91.43882  -24.80758 -89.00497  1.000 38.81462 ? 186 LYS B O   1 
ATOM   4238 C CB  . LYS B 1 186 ? -89.65918  -23.51554 -86.67598  1.000 41.33331 ? 186 LYS B CB  1 
ATOM   4239 C CG  . LYS B 1 186 ? -90.55153  -22.31345 -86.99555  1.000 32.13057 ? 186 LYS B CG  1 
ATOM   4240 C CD  . LYS B 1 186 ? -89.88272  -20.96486 -86.68477  1.000 29.78743 ? 186 LYS B CD  1 
ATOM   4241 C CE  . LYS B 1 186 ? -90.87790  -19.81246 -86.86755  1.000 29.39816 ? 186 LYS B CE  1 
ATOM   4242 N NZ  . LYS B 1 186 ? -90.25540  -18.46129 -86.81485  1.000 27.83441 ? 186 LYS B NZ  1 
ATOM   4243 N N   . ARG B 1 187 ? -89.48364  -25.92663 -88.91468  1.000 39.97318 ? 187 ARG B N   1 
ATOM   4244 C CA  . ARG B 1 187 ? -89.56121  -26.32579 -90.31629  1.000 38.87373 ? 187 ARG B CA  1 
ATOM   4245 C C   . ARG B 1 187 ? -90.80128  -27.16715 -90.58029  1.000 40.26769 ? 187 ARG B C   1 
ATOM   4246 O O   . ARG B 1 187 ? -91.45984  -27.00563 -91.61461  1.000 42.39604 ? 187 ARG B O   1 
ATOM   4247 C CB  . ARG B 1 187 ? -88.30629  -27.09740 -90.72194  1.000 40.40239 ? 187 ARG B CB  1 
ATOM   4248 C CG  . ARG B 1 187 ? -88.41765  -27.79588 -92.07811  1.000 39.17747 ? 187 ARG B CG  1 
ATOM   4249 C CD  . ARG B 1 187 ? -87.38577  -28.91540 -92.22352  1.000 45.93970 ? 187 ARG B CD  1 
ATOM   4250 N NE  . ARG B 1 187 ? -87.72903  -30.11450 -91.45452  1.000 52.41240 ? 187 ARG B NE  1 
ATOM   4251 C CZ  . ARG B 1 187 ? -86.85031  -30.81979 -90.74375  1.000 48.55139 ? 187 ARG B CZ  1 
ATOM   4252 N NH1 . ARG B 1 187 ? -85.57989  -30.44219 -90.69186  1.000 41.12626 ? 187 ARG B NH1 1 
ATOM   4253 N NH2 . ARG B 1 187 ? -87.24044  -31.89307 -90.07276  1.000 48.67625 ? 187 ARG B NH2 1 
ATOM   4254 N N   . GLU B 1 188 ? -91.13753  -28.07011 -89.65355  1.000 42.63076 ? 188 GLU B N   1 
ATOM   4255 C CA  . GLU B 1 188 ? -92.29342  -28.93849 -89.86109  1.000 46.07700 ? 188 GLU B CA  1 
ATOM   4256 C C   . GLU B 1 188 ? -93.59165  -28.14972 -89.74860  1.000 40.02354 ? 188 GLU B C   1 
ATOM   4257 O O   . GLU B 1 188 ? -94.53185  -28.36988 -90.52558  1.000 38.04337 ? 188 GLU B O   1 
ATOM   4258 C CB  . GLU B 1 188 ? -92.25756  -30.10609 -88.86858  1.000 41.12452 ? 188 GLU B CB  1 
ATOM   4259 C CG  . GLU B 1 188 ? -91.24020  -31.19870 -89.23812  1.000 41.83320 ? 188 GLU B CG  1 
ATOM   4260 C CD  . GLU B 1 188 ? -91.42134  -31.76078 -90.65697  1.000 48.58261 ? 188 GLU B CD  1 
ATOM   4261 O OE1 . GLU B 1 188 ? -92.46278  -32.39561 -90.93802  1.000 55.21361 ? 188 GLU B OE1 1 
ATOM   4262 O OE2 . GLU B 1 188 ? -90.51487  -31.57582 -91.49490  1.000 51.32652 ? 188 GLU B OE2 1 
ATOM   4263 N N   . LYS B 1 189 ? -93.64207  -27.20473 -88.80481  1.000 33.25220 ? 189 LYS B N   1 
ATOM   4264 C CA  . LYS B 1 189 ? -94.79956  -26.32840 -88.67702  1.000 35.85567 ? 189 LYS B CA  1 
ATOM   4265 C C   . LYS B 1 189 ? -95.01805  -25.49649 -89.93818  1.000 42.39000 ? 189 LYS B C   1 
ATOM   4266 O O   . LYS B 1 189 ? -96.15954  -25.30650 -90.37342  1.000 42.37341 ? 189 LYS B O   1 
ATOM   4267 C CB  . LYS B 1 189 ? -94.62957  -25.40915 -87.47256  1.000 39.25212 ? 189 LYS B CB  1 
ATOM   4268 C CG  . LYS B 1 189 ? -94.67216  -26.09867 -86.14347  1.000 39.51778 ? 189 LYS B CG  1 
ATOM   4269 C CD  . LYS B 1 189 ? -94.65707  -25.07002 -85.04335  1.000 40.85048 ? 189 LYS B CD  1 
ATOM   4270 C CE  . LYS B 1 189 ? -94.60411  -25.69872 -83.67595  1.000 42.46526 ? 189 LYS B CE  1 
ATOM   4271 N NZ  . LYS B 1 189 ? -94.46627  -24.60546 -82.69273  1.000 49.00263 ? 189 LYS B NZ  1 
ATOM   4272 N N   . ILE B 1 190 ? -93.93896  -24.96623 -90.52128  1.000 42.14075 ? 190 ILE B N   1 
ATOM   4273 C CA  . ILE B 1 190 ? -94.06324  -24.20585 -91.76298  1.000 36.49022 ? 190 ILE B CA  1 
ATOM   4274 C C   . ILE B 1 190 ? -94.47312  -25.12615 -92.90241  1.000 38.81209 ? 190 ILE B C   1 
ATOM   4275 O O   . ILE B 1 190 ? -95.29348  -24.75711 -93.75400  1.000 40.35652 ? 190 ILE B O   1 
ATOM   4276 C CB  . ILE B 1 190 ? -92.74742  -23.46221 -92.06508  1.000 31.79514 ? 190 ILE B CB  1 
ATOM   4277 C CG1 . ILE B 1 190 ? -92.49295  -22.40256 -90.99906  1.000 29.72504 ? 190 ILE B CG1 1 
ATOM   4278 C CG2 . ILE B 1 190 ? -92.76465  -22.81628 -93.45289  1.000 30.03802 ? 190 ILE B CG2 1 
ATOM   4279 C CD1 . ILE B 1 190 ? -91.08411  -21.82448 -91.03328  1.000 28.85936 ? 190 ILE B CD1 1 
ATOM   4280 N N   . PHE B 1 191 ? -93.92081  -26.34313 -92.92860  1.000 40.07016 ? 191 PHE B N   1 
ATOM   4281 C CA  . PHE B 1 191 ? -94.32850  -27.31806 -93.93273  1.000 39.09451 ? 191 PHE B CA  1 
ATOM   4282 C C   . PHE B 1 191 ? -95.81228  -27.63581 -93.80080  1.000 42.95876 ? 191 PHE B C   1 
ATOM   4283 O O   . PHE B 1 191 ? -96.56650  -27.55624 -94.77665  1.000 41.23359 ? 191 PHE B O   1 
ATOM   4284 C CB  . PHE B 1 191 ? -93.49242  -28.59431 -93.80410  1.000 44.47555 ? 191 PHE B CB  1 
ATOM   4285 C CG  . PHE B 1 191 ? -93.90165  -29.68016 -94.76633  1.000 47.19885 ? 191 PHE B CG  1 
ATOM   4286 C CD1 . PHE B 1 191 ? -93.41762  -29.69051 -96.06952  1.000 50.81895 ? 191 PHE B CD1 1 
ATOM   4287 C CD2 . PHE B 1 191 ? -94.78555  -30.67750 -94.37596  1.000 41.30227 ? 191 PHE B CD2 1 
ATOM   4288 C CE1 . PHE B 1 191 ? -93.80172  -30.68236 -96.95776  1.000 47.61994 ? 191 PHE B CE1 1 
ATOM   4289 C CE2 . PHE B 1 191 ? -95.17064  -31.66769 -95.25474  1.000 37.60969 ? 191 PHE B CE2 1 
ATOM   4290 C CZ  . PHE B 1 191 ? -94.68148  -31.66894 -96.54755  1.000 44.07238 ? 191 PHE B CZ  1 
ATOM   4291 N N   . ALA B 1 192 ? -96.24947  -27.97276 -92.58367  1.000 37.20326 ? 192 ALA B N   1 
ATOM   4292 C CA  . ALA B 1 192 ? -97.63986  -28.34559 -92.36054  1.000 36.50006 ? 192 ALA B CA  1 
ATOM   4293 C C   . ALA B 1 192 ? -98.59141  -27.22284 -92.76189  1.000 43.29241 ? 192 ALA B C   1 
ATOM   4294 O O   . ALA B 1 192 ? -99.63251  -27.47171 -93.37993  1.000 49.02652 ? 192 ALA B O   1 
ATOM   4295 C CB  . ALA B 1 192 ? -97.83720  -28.72770 -90.89263  1.000 33.92922 ? 192 ALA B CB  1 
ATOM   4296 N N   . LEU B 1 193 ? -98.23948  -25.97847 -92.43255  1.000 43.92038 ? 193 LEU B N   1 
ATOM   4297 C CA  . LEU B 1 193 ? -99.10613  -24.84357 -92.73130  1.000 39.48334 ? 193 LEU B CA  1 
ATOM   4298 C C   . LEU B 1 193 ? -99.24043  -24.62709 -94.23576  1.000 42.01529 ? 193 LEU B C   1 
ATOM   4299 O O   . LEU B 1 193 ? -100.35718 -24.51120 -94.75547  1.000 44.95080 ? 193 LEU B O   1 
ATOM   4300 C CB  . LEU B 1 193 ? -98.56680  -23.58535 -92.04286  1.000 37.38549 ? 193 LEU B CB  1 
ATOM   4301 C CG  . LEU B 1 193 ? -99.10654  -22.23061 -92.51847  1.000 37.37746 ? 193 LEU B CG  1 
ATOM   4302 C CD1 . LEU B 1 193 ? -100.62264 -22.18299 -92.47577  1.000 40.44787 ? 193 LEU B CD1 1 
ATOM   4303 C CD2 . LEU B 1 193 ? -98.53481  -21.10925 -91.68343  1.000 31.28669 ? 193 LEU B CD2 1 
ATOM   4304 N N   . VAL B 1 194 ? -98.11290  -24.56694 -94.95137  1.000 32.44242 ? 194 VAL B N   1 
ATOM   4305 C CA  . VAL B 1 194 ? -98.15780  -24.33933 -96.39348  1.000 40.18853 ? 194 VAL B CA  1 
ATOM   4306 C C   . VAL B 1 194 ? -98.85475  -25.49496 -97.10602  1.000 44.71954 ? 194 VAL B C   1 
ATOM   4307 O O   . VAL B 1 194 ? -99.66112  -25.27620 -98.01807  1.000 47.18367 ? 194 VAL B O   1 
ATOM   4308 C CB  . VAL B 1 194 ? -96.73762  -24.10313 -96.94028  1.000 36.90918 ? 194 VAL B CB  1 
ATOM   4309 C CG1 . VAL B 1 194 ? -96.75916  -23.93878 -98.45951  1.000 33.04414 ? 194 VAL B CG1 1 
ATOM   4310 C CG2 . VAL B 1 194 ? -96.13707  -22.88271 -96.28249  1.000 35.89238 ? 194 VAL B CG2 1 
ATOM   4311 N N   . LYS B 1 195 ? -98.55841  -26.73808 -96.70853  1.000 47.43183 ? 195 LYS B N   1 
ATOM   4312 C CA  . LYS B 1 195 ? -99.22862  -27.89179 -97.30598  1.000 48.65702 ? 195 LYS B CA  1 
ATOM   4313 C C   . LYS B 1 195 ? -100.74057 -27.78604 -97.13806  1.000 45.56655 ? 195 LYS B C   1 
ATOM   4314 O O   . LYS B 1 195 ? -101.49940 -27.99127 -98.09057  1.000 46.33293 ? 195 LYS B O   1 
ATOM   4315 C CB  . LYS B 1 195 ? -98.69876  -29.19332 -96.68810  1.000 51.70373 ? 195 LYS B CB  1 
ATOM   4316 C CG  . LYS B 1 195 ? -99.35013  -30.46788 -97.24106  1.000 58.45586 ? 195 LYS B CG  1 
ATOM   4317 C CD  . LYS B 1 195 ? -98.86366  -31.73410 -96.52549  1.000 53.17533 ? 195 LYS B CD  1 
ATOM   4318 C CE  . LYS B 1 195 ? -99.75202  -32.93083 -96.87632  1.000 50.69169 ? 195 LYS B CE  1 
ATOM   4319 N NZ  . LYS B 1 195 ? -99.83925  -33.16612 -98.34959  1.000 50.99534 ? 195 LYS B NZ  1 
ATOM   4320 N N   . SER B 1 196 ? -101.19388 -27.42734 -95.93673  1.000 48.57406 ? 196 SER B N   1 
ATOM   4321 C CA  . SER B 1 196 ? -102.62854 -27.29705 -95.69283  1.000 47.36102 ? 196 SER B CA  1 
ATOM   4322 C C   . SER B 1 196 ? -103.27162 -26.28900 -96.63828  1.000 43.64440 ? 196 SER B C   1 
ATOM   4323 O O   . SER B 1 196 ? -104.37094 -26.52673 -97.14790  1.000 57.29652 ? 196 SER B O   1 
ATOM   4324 C CB  . SER B 1 196 ? -102.87221 -26.90846 -94.23743  1.000 44.61864 ? 196 SER B CB  1 
ATOM   4325 O OG  . SER B 1 196 ? -104.08938 -26.20714 -94.09917  1.000 57.72652 ? 196 SER B OG  1 
ATOM   4326 N N   . LEU B 1 197 ? -102.59694 -25.16479 -96.90188  1.000 46.42505 ? 197 LEU B N   1 
ATOM   4327 C CA  . LEU B 1 197 ? -103.13440 -24.18134 -97.84239  1.000 44.58198 ? 197 LEU B CA  1 
ATOM   4328 C C   . LEU B 1 197 ? -103.01323 -24.65756 -99.28754  1.000 53.93652 ? 197 LEU B C   1 
ATOM   4329 O O   . LEU B 1 197 ? -103.92136 -24.42824 -100.09928 1.000 44.65219 ? 197 LEU B O   1 
ATOM   4330 C CB  . LEU B 1 197 ? -102.42612 -22.83979 -97.67884  1.000 38.96411 ? 197 LEU B CB  1 
ATOM   4331 C CG  . LEU B 1 197 ? -102.49586 -22.13367 -96.32950  1.000 43.61811 ? 197 LEU B CG  1 
ATOM   4332 C CD1 . LEU B 1 197 ? -101.37704 -21.11360 -96.24324  1.000 27.86916 ? 197 LEU B CD1 1 
ATOM   4333 C CD2 . LEU B 1 197 ? -103.84018 -21.45699 -96.17082  1.000 39.67639 ? 197 LEU B CD2 1 
ATOM   4334 N N   . ARG B 1 198 ? -101.88535 -25.28613 -99.63870  1.000 49.16188 ? 198 ARG B N   1 
ATOM   4335 C CA  . ARG B 1 198 ? -101.73906 -25.85112 -100.97745 1.000 45.60522 ? 198 ARG B CA  1 
ATOM   4336 C C   . ARG B 1 198 ? -102.84223 -26.86487 -101.26021 1.000 49.94833 ? 198 ARG B C   1 
ATOM   4337 O O   . ARG B 1 198 ? -103.48347 -26.82845 -102.31803 1.000 46.30270 ? 198 ARG B O   1 
ATOM   4338 C CB  . ARG B 1 198 ? -100.36237 -26.50237 -101.13319 1.000 50.34441 ? 198 ARG B CB  1 
ATOM   4339 C CG  . ARG B 1 198 ? -99.20154  -25.53384 -101.11121 1.000 43.57936 ? 198 ARG B CG  1 
ATOM   4340 C CD  . ARG B 1 198 ? -99.03107  -24.89594 -102.46781 1.000 44.94981 ? 198 ARG B CD  1 
ATOM   4341 N NE  . ARG B 1 198 ? -98.28845  -25.75780 -103.38360 1.000 50.99713 ? 198 ARG B NE  1 
ATOM   4342 C CZ  . ARG B 1 198 ? -97.95967  -25.42676 -104.63052 1.000 46.35735 ? 198 ARG B CZ  1 
ATOM   4343 N NH1 . ARG B 1 198 ? -98.31097  -24.24410 -105.13620 1.000 35.29531 ? 198 ARG B NH1 1 
ATOM   4344 N NH2 . ARG B 1 198 ? -97.27992  -26.28532 -105.37595 1.000 43.81917 ? 198 ARG B NH2 1 
ATOM   4345 N N   . ASP B 1 199 ? -103.08478 -27.77342 -100.31146 1.000 49.11735 ? 199 ASP B N   1 
ATOM   4346 C CA  . ASP B 1 199 ? -104.08572 -28.81219 -100.51789 1.000 47.14631 ? 199 ASP B CA  1 
ATOM   4347 C C   . ASP B 1 199 ? -105.48960 -28.23220 -100.61567 1.000 48.50887 ? 199 ASP B C   1 
ATOM   4348 O O   . ASP B 1 199 ? -106.32350 -28.77390 -101.34701 1.000 56.76169 ? 199 ASP B O   1 
ATOM   4349 C CB  . ASP B 1 199 ? -104.01624 -29.85063 -99.39318  1.000 51.97716 ? 199 ASP B CB  1 
ATOM   4350 C CG  . ASP B 1 199 ? -102.72933 -30.66873 -99.42221  1.000 47.50936 ? 199 ASP B CG  1 
ATOM   4351 O OD1 . ASP B 1 199 ? -102.06311 -30.70113 -100.48428 1.000 46.46443 ? 199 ASP B OD1 1 
ATOM   4352 O OD2 . ASP B 1 199 ? -102.39923 -31.28858 -98.38316  1.000 50.18766 ? 199 ASP B OD2 1 
ATOM   4353 N N   . LYS B 1 200 ? -105.77279 -27.13833 -99.90314  1.000 44.58276 ? 200 LYS B N   1 
ATOM   4354 C CA  . LYS B 1 200 ? -107.07593 -26.48658 -99.99901  1.000 41.47807 ? 200 LYS B CA  1 
ATOM   4355 C C   . LYS B 1 200 ? -107.26512 -25.68610 -101.28133 1.000 37.79195 ? 200 LYS B C   1 
ATOM   4356 O O   . LYS B 1 200 ? -108.31619 -25.06191 -101.43997 1.000 41.90345 ? 200 LYS B O   1 
ATOM   4357 C CB  . LYS B 1 200 ? -107.30597 -25.55749 -98.80773  1.000 47.44312 ? 200 LYS B CB  1 
ATOM   4358 C CG  . LYS B 1 200 ? -107.78584 -26.25246 -97.55291  1.000 43.99370 ? 200 LYS B CG  1 
ATOM   4359 C CD  . LYS B 1 200 ? -108.07130 -25.23726 -96.47229  1.000 39.81173 ? 200 LYS B CD  1 
ATOM   4360 C CE  . LYS B 1 200 ? -107.63325 -25.73702 -95.11173  1.000 53.17672 ? 200 LYS B CE  1 
ATOM   4361 N NZ  . LYS B 1 200 ? -106.46950 -24.95130 -94.62613  1.000 56.69652 ? 200 LYS B NZ  1 
ATOM   4362 N N   . GLY B 1 201 ? -106.28721 -25.67062 -102.18278 1.000 37.30806 ? 201 GLY B N   1 
ATOM   4363 C CA  . GLY B 1 201 ? -106.39944 -24.91281 -103.41494 1.000 46.20320 ? 201 GLY B CA  1 
ATOM   4364 C C   . GLY B 1 201 ? -106.07918 -23.43543 -103.30834 1.000 48.76445 ? 201 GLY B C   1 
ATOM   4365 O O   . GLY B 1 201 ? -106.27549 -22.70045 -104.28930 1.000 42.41810 ? 201 GLY B O   1 
ATOM   4366 N N   . ILE B 1 202 ? -105.58668 -22.98282 -102.16034 1.000 47.64701 ? 202 ILE B N   1 
ATOM   4367 C CA  . ILE B 1 202 ? -105.28429 -21.56226 -101.94016 1.000 41.70221 ? 202 ILE B CA  1 
ATOM   4368 C C   . ILE B 1 202 ? -104.12192 -21.14851 -102.83779 1.000 33.46817 ? 202 ILE B C   1 
ATOM   4369 O O   . ILE B 1 202 ? -103.15640 -21.91710 -102.98695 1.000 35.64203 ? 202 ILE B O   1 
ATOM   4370 C CB  . ILE B 1 202 ? -104.96892 -21.32260 -100.46034 1.000 38.79572 ? 202 ILE B CB  1 
ATOM   4371 C CG1 . ILE B 1 202 ? -106.18297 -21.70950 -99.60938  1.000 43.34723 ? 202 ILE B CG1 1 
ATOM   4372 C CG2 . ILE B 1 202 ? -104.56539 -19.88128 -100.18861 1.000 36.29338 ? 202 ILE B CG2 1 
ATOM   4373 C CD1 . ILE B 1 202 ? -107.37528 -20.78047 -99.77976  1.000 38.52840 ? 202 ILE B CD1 1 
ATOM   4374 N N   . PRO B 1 203 ? -104.16741 -19.96939 -103.47341 1.000 32.04937 ? 203 PRO B N   1 
ATOM   4375 C CA  . PRO B 1 203 ? -103.07664 -19.59476 -104.39829 1.000 34.26730 ? 203 PRO B CA  1 
ATOM   4376 C C   . PRO B 1 203 ? -101.82112 -19.10796 -103.67275 1.000 38.29809 ? 203 PRO B C   1 
ATOM   4377 O O   . PRO B 1 203 ? -101.45077 -17.91991 -103.65675 1.000 36.82582 ? 203 PRO B O   1 
ATOM   4378 C CB  . PRO B 1 203 ? -103.74009 -18.51140 -105.25968 1.000 32.26308 ? 203 PRO B CB  1 
ATOM   4379 C CG  . PRO B 1 203 ? -104.72047 -17.86652 -104.36347 1.000 30.47613 ? 203 PRO B CG  1 
ATOM   4380 C CD  . PRO B 1 203 ? -105.23249 -18.94854 -103.43132 1.000 30.98393 ? 203 PRO B CD  1 
ATOM   4381 N N   . ILE B 1 204 ? -101.11554 -20.04786 -103.04741 1.000 33.52480 ? 204 ILE B N   1 
ATOM   4382 C CA  . ILE B 1 204 ? -99.81953  -19.79165 -102.43124 1.000 36.29121 ? 204 ILE B CA  1 
ATOM   4383 C C   . ILE B 1 204 ? -98.76028  -20.47070 -103.29441 1.000 35.59210 ? 204 ILE B C   1 
ATOM   4384 O O   . ILE B 1 204 ? -98.78763  -21.69115 -103.49020 1.000 43.81222 ? 204 ILE B O   1 
ATOM   4385 C CB  . ILE B 1 204 ? -99.77963  -20.26840 -100.96523 1.000 31.18091 ? 204 ILE B CB  1 
ATOM   4386 C CG1 . ILE B 1 204 ? -98.38914  -20.08498 -100.36498 1.000 32.64417 ? 204 ILE B CG1 1 
ATOM   4387 C CG2 . ILE B 1 204 ? -100.23205 -21.71281 -100.82348 1.000 38.10336 ? 204 ILE B CG2 1 
ATOM   4388 C CD1 . ILE B 1 204 ? -98.36557  -20.31987 -98.86787  1.000 26.96761 ? 204 ILE B CD1 1 
ATOM   4389 N N   . HIS B 1 205 ? -97.84597  -19.67659 -103.83802 1.000 33.82201 ? 205 HIS B N   1 
ATOM   4390 C CA  . HIS B 1 205 ? -96.87792  -20.16366 -104.80439 1.000 32.37527 ? 205 HIS B CA  1 
ATOM   4391 C C   . HIS B 1 205 ? -95.45722  -20.30615 -104.26860 1.000 30.60938 ? 205 HIS B C   1 
ATOM   4392 O O   . HIS B 1 205 ? -94.64643  -20.98425 -104.91069 1.000 30.37744 ? 205 HIS B O   1 
ATOM   4393 C CB  . HIS B 1 205 ? -96.85182  -19.23612 -106.02454 1.000 29.90712 ? 205 HIS B CB  1 
ATOM   4394 C CG  . HIS B 1 205 ? -98.20950  -18.81356 -106.48224 1.000 43.06652 ? 205 HIS B CG  1 
ATOM   4395 N ND1 . HIS B 1 205 ? -98.71005  -17.54734 -106.26564 1.000 37.95193 ? 205 HIS B ND1 1 
ATOM   4396 C CD2 . HIS B 1 205 ? -99.17975  -19.49753 -107.13475 1.000 42.97316 ? 205 HIS B CD2 1 
ATOM   4397 C CE1 . HIS B 1 205 ? -99.92583  -17.46693 -106.77284 1.000 39.69905 ? 205 HIS B CE1 1 
ATOM   4398 N NE2 . HIS B 1 205 ? -100.23372 -18.63687 -107.30625 1.000 34.44381 ? 205 HIS B NE2 1 
ATOM   4399 N N   . GLY B 1 206 ? -95.12389  -19.69596 -103.13038 1.000 33.58452 ? 206 GLY B N   1 
ATOM   4400 C CA  . GLY B 1 206 ? -93.74057  -19.66665 -102.69090 1.000 25.70006 ? 206 GLY B CA  1 
ATOM   4401 C C   . GLY B 1 206 ? -93.59674  -19.67831 -101.18522 1.000 33.44988 ? 206 GLY B C   1 
ATOM   4402 O O   . GLY B 1 206 ? -94.50488  -19.29434 -100.43609 1.000 29.62151 ? 206 GLY B O   1 
ATOM   4403 N N   . ILE B 1 207 ? -92.43050  -20.14156 -100.75069 1.000 31.52222 ? 207 ILE B N   1 
ATOM   4404 C CA  . ILE B 1 207 ? -92.00993  -20.06137 -99.35976  1.000 32.28441 ? 207 ILE B CA  1 
ATOM   4405 C C   . ILE B 1 207 ? -90.78590  -19.16832 -99.33405  1.000 29.36335 ? 207 ILE B C   1 
ATOM   4406 O O   . ILE B 1 207 ? -89.86723  -19.35052 -100.13503 1.000 30.62743 ? 207 ILE B O   1 
ATOM   4407 C CB  . ILE B 1 207 ? -91.70374  -21.44963 -98.76375  1.000 30.18195 ? 207 ILE B CB  1 
ATOM   4408 C CG1 . ILE B 1 207 ? -93.00853  -22.19682 -98.45618  1.000 28.93856 ? 207 ILE B CG1 1 
ATOM   4409 C CG2 . ILE B 1 207 ? -90.82934  -21.33765 -97.50565  1.000 21.21717 ? 207 ILE B CG2 1 
ATOM   4410 C CD1 . ILE B 1 207 ? -92.79351  -23.62550 -97.99926  1.000 34.23340 ? 207 ILE B CD1 1 
ATOM   4411 N N   . GLY B 1 208 ? -90.80468  -18.16036 -98.45917  1.000 25.60543 ? 208 GLY B N   1 
ATOM   4412 C CA  . GLY B 1 208 ? -89.68594  -17.27097 -98.29474  1.000 27.88092 ? 208 GLY B CA  1 
ATOM   4413 C C   . GLY B 1 208 ? -88.89945  -17.69422 -97.07253  1.000 31.70987 ? 208 GLY B C   1 
ATOM   4414 O O   . GLY B 1 208 ? -89.41648  -17.67302 -95.95343  1.000 30.33380 ? 208 GLY B O   1 
ATOM   4415 N N   . MET B 1 209 ? -87.65259  -18.10899 -97.29645  1.000 27.86615 ? 209 MET B N   1 
ATOM   4416 C CA  . MET B 1 209 ? -86.74520  -18.45706 -96.20914  1.000 26.06422 ? 209 MET B CA  1 
ATOM   4417 C C   . MET B 1 209 ? -85.94787  -17.20493 -95.87424  1.000 26.31046 ? 209 MET B C   1 
ATOM   4418 O O   . MET B 1 209 ? -85.10381  -16.77526 -96.66810  1.000 24.22148 ? 209 MET B O   1 
ATOM   4419 C CB  . MET B 1 209 ? -85.84038  -19.61475 -96.62007  1.000 27.54153 ? 209 MET B CB  1 
ATOM   4420 C CG  . MET B 1 209 ? -86.61228  -20.88869 -96.97856  1.000 31.08708 ? 209 MET B CG  1 
ATOM   4421 S SD  . MET B 1 209 ? -85.58151  -22.19437 -97.68269  1.000 33.56197 ? 209 MET B SD  1 
ATOM   4422 C CE  . MET B 1 209 ? -84.33028  -22.36016 -96.40492  1.000 29.66428 ? 209 MET B CE  1 
ATOM   4423 N N   . GLN B 1 210 ? -86.22786  -16.59948 -94.71387  1.000 23.77746 ? 210 GLN B N   1 
ATOM   4424 C CA  . GLN B 1 210 ? -85.53811  -15.35551 -94.37929  1.000 25.07084 ? 210 GLN B CA  1 
ATOM   4425 C C   . GLN B 1 210 ? -84.03444  -15.56422 -94.26010  1.000 26.80894 ? 210 GLN B C   1 
ATOM   4426 O O   . GLN B 1 210 ? -83.25641  -14.69973 -94.67547  1.000 27.82747 ? 210 GLN B O   1 
ATOM   4427 C CB  . GLN B 1 210 ? -86.11083  -14.74528 -93.10396  1.000 24.62019 ? 210 GLN B CB  1 
ATOM   4428 C CG  . GLN B 1 210 ? -87.42841  -14.00863 -93.36050  1.000 24.88712 ? 210 GLN B CG  1 
ATOM   4429 C CD  . GLN B 1 210 ? -87.97030  -13.31134 -92.13064  1.000 29.47991 ? 210 GLN B CD  1 
ATOM   4430 O OE1 . GLN B 1 210 ? -87.21967  -12.70135 -91.36940  1.000 24.18513 ? 210 GLN B OE1 1 
ATOM   4431 N NE2 . GLN B 1 210 ? -89.27734  -13.40197 -91.92634  1.000 26.67258 ? 210 GLN B NE2 1 
ATOM   4432 N N   . ALA B 1 211 ? -83.60109  -16.70866 -93.71449  1.000 26.63696 ? 211 ALA B N   1 
ATOM   4433 C CA  . ALA B 1 211 ? -82.17501  -17.03958 -93.61623  1.000 25.67745 ? 211 ALA B CA  1 
ATOM   4434 C C   . ALA B 1 211 ? -81.40066  -15.99600 -92.80746  1.000 24.11310 ? 211 ALA B C   1 
ATOM   4435 O O   . ALA B 1 211 ? -80.36831  -15.47350 -93.23965  1.000 25.60435 ? 211 ALA B O   1 
ATOM   4436 C CB  . ALA B 1 211 ? -81.55643  -17.22198 -95.00384  1.000 20.90525 ? 211 ALA B CB  1 
ATOM   4437 N N   . HIS B 1 212 ? -81.91036  -15.68438 -91.61628  1.000 27.53560 ? 212 HIS B N   1 
ATOM   4438 C CA  . HIS B 1 212 ? -81.15828  -14.87633 -90.65478  1.000 27.02320 ? 212 HIS B CA  1 
ATOM   4439 C C   . HIS B 1 212 ? -80.34204  -15.85404 -89.82521  1.000 28.56473 ? 212 HIS B C   1 
ATOM   4440 O O   . HIS B 1 212 ? -80.80694  -16.41525 -88.83078  1.000 30.26140 ? 212 HIS B O   1 
ATOM   4441 C CB  . HIS B 1 212 ? -82.08345  -14.01522 -89.80820  1.000 24.38475 ? 212 HIS B CB  1 
ATOM   4442 C CG  . HIS B 1 212 ? -82.69404  -12.88969 -90.57376  1.000 24.85723 ? 212 HIS B CG  1 
ATOM   4443 N ND1 . HIS B 1 212 ? -81.94128  -11.88895 -91.14953  1.000 32.96652 ? 212 HIS B ND1 1 
ATOM   4444 C CD2 . HIS B 1 212 ? -83.98183  -12.61802 -90.88230  1.000 25.24437 ? 212 HIS B CD2 1 
ATOM   4445 C CE1 . HIS B 1 212 ? -82.74072  -11.03805 -91.76513  1.000 23.68045 ? 212 HIS B CE1 1 
ATOM   4446 N NE2 . HIS B 1 212 ? -83.98460  -11.46003 -91.62089  1.000 19.75858 ? 212 HIS B NE2 1 
ATOM   4447 N N   . TRP B 1 213 ? -79.11396  -16.07207 -90.26454  1.000 25.84988 ? 213 TRP B N   1 
ATOM   4448 C CA  . TRP B 1 213 ? -78.28902  -17.16447 -89.79764  1.000 27.99002 ? 213 TRP B CA  1 
ATOM   4449 C C   . TRP B 1 213 ? -77.09915  -16.63277 -89.00579  1.000 27.69341 ? 213 TRP B C   1 
ATOM   4450 O O   . TRP B 1 213 ? -76.77453  -15.43876 -89.03861  1.000 24.69948 ? 213 TRP B O   1 
ATOM   4451 C CB  . TRP B 1 213 ? -77.84282  -18.00148 -90.99515  1.000 27.65603 ? 213 TRP B CB  1 
ATOM   4452 C CG  . TRP B 1 213 ? -78.98621  -18.71698 -91.64349  1.000 26.19072 ? 213 TRP B CG  1 
ATOM   4453 C CD1 . TRP B 1 213 ? -80.21407  -18.95711 -91.09646  1.000 27.76212 ? 213 TRP B CD1 1 
ATOM   4454 C CD2 . TRP B 1 213 ? -79.00653  -19.31522 -92.94679  1.000 24.10353 ? 213 TRP B CD2 1 
ATOM   4455 N NE1 . TRP B 1 213 ? -81.00284  -19.66186 -91.98150  1.000 26.09436 ? 213 TRP B NE1 1 
ATOM   4456 C CE2 . TRP B 1 213 ? -80.28307  -19.89360 -93.12363  1.000 28.20275 ? 213 TRP B CE2 1 
ATOM   4457 C CE3 . TRP B 1 213 ? -78.07909  -19.40434 -93.98701  1.000 28.42758 ? 213 TRP B CE3 1 
ATOM   4458 C CZ2 . TRP B 1 213 ? -80.64459  -20.55931 -94.29157  1.000 30.58055 ? 213 TRP B CZ2 1 
ATOM   4459 C CZ3 . TRP B 1 213 ? -78.43720  -20.06240 -95.13861  1.000 27.64970 ? 213 TRP B CZ3 1 
ATOM   4460 C CH2 . TRP B 1 213 ? -79.71431  -20.63129 -95.28674  1.000 29.26552 ? 213 TRP B CH2 1 
ATOM   4461 N N   . SER B 1 214 ? -76.46266  -17.53515 -88.25880  1.000 32.26937 ? 214 SER B N   1 
ATOM   4462 C CA  . SER B 1 214 ? -75.20082  -17.25694 -87.57969  1.000 29.48661 ? 214 SER B CA  1 
ATOM   4463 C C   . SER B 1 214 ? -74.08173  -18.03147 -88.27052  1.000 31.46629 ? 214 SER B C   1 
ATOM   4464 O O   . SER B 1 214 ? -74.30170  -18.69650 -89.28919  1.000 27.33184 ? 214 SER B O   1 
ATOM   4465 C CB  . SER B 1 214 ? -75.29623  -17.59357 -86.08608  1.000 25.97553 ? 214 SER B CB  1 
ATOM   4466 O OG  . SER B 1 214 ? -75.09926  -18.98592 -85.86684  1.000 29.42304 ? 214 SER B OG  1 
ATOM   4467 N N   . LEU B 1 215 ? -72.86684  -17.91932 -87.70977  1.000 29.94661 ? 215 LEU B N   1 
ATOM   4468 C CA  . LEU B 1 215 ? -71.71632  -18.63627 -88.25138  1.000 27.24055 ? 215 LEU B CA  1 
ATOM   4469 C C   . LEU B 1 215 ? -71.88484  -20.14209 -88.13778  1.000 29.64290 ? 215 LEU B C   1 
ATOM   4470 O O   . LEU B 1 215 ? -71.30964  -20.88475 -88.93750  1.000 36.37466 ? 215 LEU B O   1 
ATOM   4471 C CB  . LEU B 1 215 ? -70.42939  -18.20406 -87.53614  1.000 26.79048 ? 215 LEU B CB  1 
ATOM   4472 C CG  . LEU B 1 215 ? -70.02048  -16.74707 -87.75310  1.000 23.06225 ? 215 LEU B CG  1 
ATOM   4473 C CD1 . LEU B 1 215 ? -68.87508  -16.29854 -86.81685  1.000 27.48541 ? 215 LEU B CD1 1 
ATOM   4474 C CD2 . LEU B 1 215 ? -69.65404  -16.57182 -89.19699  1.000 14.88233 ? 215 LEU B CD2 1 
ATOM   4475 N N   . THR B 1 216 ? -72.65632  -20.61602 -87.15888  1.000 29.03767 ? 216 THR B N   1 
ATOM   4476 C CA  . THR B 1 216 ? -72.82782  -22.05112 -86.95272  1.000 36.57160 ? 216 THR B CA  1 
ATOM   4477 C C   . THR B 1 216 ? -74.25841  -22.55516 -87.10731  1.000 33.26205 ? 216 THR B C   1 
ATOM   4478 O O   . THR B 1 216 ? -74.43420  -23.72710 -87.44612  1.000 38.94180 ? 216 THR B O   1 
ATOM   4479 C CB  . THR B 1 216 ? -72.32341  -22.47938 -85.55778  1.000 36.14687 ? 216 THR B CB  1 
ATOM   4480 O OG1 . THR B 1 216 ? -73.19489  -21.95767 -84.54686  1.000 43.14652 ? 216 THR B OG1 1 
ATOM   4481 C CG2 . THR B 1 216 ? -70.88168  -22.00453 -85.30981  1.000 32.19380 ? 216 THR B CG2 1 
ATOM   4482 N N   . ARG B 1 217 ? -75.28211  -21.72960 -86.86281  1.000 28.85857 ? 217 ARG B N   1 
ATOM   4483 C CA  . ARG B 1 217 ? -76.63968  -22.27443 -86.92364  1.000 36.30922 ? 217 ARG B CA  1 
ATOM   4484 C C   . ARG B 1 217 ? -77.48996  -21.53366 -87.95175  1.000 32.69655 ? 217 ARG B C   1 
ATOM   4485 O O   . ARG B 1 217 ? -77.36264  -20.30974 -88.10607  1.000 31.63592 ? 217 ARG B O   1 
ATOM   4486 C CB  . ARG B 1 217 ? -77.34405  -22.23137 -85.54245  1.000 36.80943 ? 217 ARG B CB  1 
ATOM   4487 C CG  . ARG B 1 217 ? -76.45744  -22.72868 -84.38633  1.000 48.80764 ? 217 ARG B CG  1 
ATOM   4488 C CD  . ARG B 1 217 ? -77.21115  -23.01413 -83.08338  1.000 57.84559 ? 217 ARG B CD  1 
ATOM   4489 N NE  . ARG B 1 217 ? -78.37305  -23.88448 -83.27993  1.000 70.45419 ? 217 ARG B NE  1 
ATOM   4490 C CZ  . ARG B 1 217 ? -79.58544  -23.62681 -82.79665  1.000 64.93121 ? 217 ARG B CZ  1 
ATOM   4491 N NH1 . ARG B 1 217 ? -79.78926  -22.52673 -82.08124  1.000 68.35652 ? 217 ARG B NH1 1 
ATOM   4492 N NH2 . ARG B 1 217 ? -80.59204  -24.46751 -83.01931  1.000 61.82350 ? 217 ARG B NH2 1 
ATOM   4493 N N   . PRO B 1 218 ? -78.34968  -22.24896 -88.69358  1.000 38.08643 ? 218 PRO B N   1 
ATOM   4494 C CA  . PRO B 1 218 ? -78.48764  -23.70722 -88.65998  1.000 34.42727 ? 218 PRO B CA  1 
ATOM   4495 C C   . PRO B 1 218 ? -77.29113  -24.41241 -89.26640  1.000 36.41178 ? 218 PRO B C   1 
ATOM   4496 O O   . PRO B 1 218 ? -76.47732  -23.77937 -89.93920  1.000 42.14843 ? 218 PRO B O   1 
ATOM   4497 C CB  . PRO B 1 218 ? -79.71825  -23.96617 -89.53148  1.000 29.83964 ? 218 PRO B CB  1 
ATOM   4498 C CG  . PRO B 1 218 ? -79.72819  -22.83134 -90.49415  1.000 28.95944 ? 218 PRO B CG  1 
ATOM   4499 C CD  . PRO B 1 218 ? -79.23591  -21.64664 -89.70702  1.000 28.08828 ? 218 PRO B CD  1 
ATOM   4500 N N   . SER B 1 219 ? -77.20482  -25.71795 -89.03993  1.000 36.52433 ? 219 SER B N   1 
ATOM   4501 C CA  . SER B 1 219 ? -76.18815  -26.52825 -89.68797  1.000 38.05838 ? 219 SER B CA  1 
ATOM   4502 C C   . SER B 1 219 ? -76.48541  -26.67966 -91.17896  1.000 42.06476 ? 219 SER B C   1 
ATOM   4503 O O   . SER B 1 219 ? -77.62722  -26.52931 -91.63489  1.000 39.21304 ? 219 SER B O   1 
ATOM   4504 C CB  . SER B 1 219 ? -76.12243  -27.89891 -89.02624  1.000 32.81568 ? 219 SER B CB  1 
ATOM   4505 O OG  . SER B 1 219 ? -76.90956  -28.82478 -89.75610  1.000 46.76948 ? 219 SER B OG  1 
ATOM   4506 N N   . LEU B 1 220 ? -75.43586  -26.99397 -91.94635  1.000 44.61746 ? 220 LEU B N   1 
ATOM   4507 C CA  . LEU B 1 220 ? -75.62623  -27.23056 -93.37570  1.000 45.40692 ? 220 LEU B CA  1 
ATOM   4508 C C   . LEU B 1 220 ? -76.62014  -28.35534 -93.62575  1.000 41.59348 ? 220 LEU B C   1 
ATOM   4509 O O   . LEU B 1 220 ? -77.37078  -28.31589 -94.60394  1.000 38.63223 ? 220 LEU B O   1 
ATOM   4510 C CB  . LEU B 1 220 ? -74.29892  -27.55323 -94.04894  1.000 44.36436 ? 220 LEU B CB  1 
ATOM   4511 C CG  . LEU B 1 220 ? -73.34664  -26.38719 -94.25790  1.000 45.06909 ? 220 LEU B CG  1 
ATOM   4512 C CD1 . LEU B 1 220 ? -72.10988  -26.91002 -94.94332  1.000 35.96801 ? 220 LEU B CD1 1 
ATOM   4513 C CD2 . LEU B 1 220 ? -74.01099  -25.31465 -95.09083  1.000 37.08662 ? 220 LEU B CD2 1 
ATOM   4514 N N   . ASP B 1 221 ? -76.62566  -29.37558 -92.76034  1.000 46.09566 ? 221 ASP B N   1 
ATOM   4515 C CA  . ASP B 1 221 ? -77.58208  -30.47277 -92.90413  1.000 45.53991 ? 221 ASP B CA  1 
ATOM   4516 C C   . ASP B 1 221 ? -79.01345  -29.98960 -92.68391  1.000 40.34518 ? 221 ASP B C   1 
ATOM   4517 O O   . ASP B 1 221 ? -79.94008  -30.43117 -93.37271  1.000 40.63961 ? 221 ASP B O   1 
ATOM   4518 C CB  . ASP B 1 221 ? -77.26003  -31.60797 -91.91789  1.000 41.84542 ? 221 ASP B CB  1 
ATOM   4519 C CG  . ASP B 1 221 ? -75.97486  -32.36968 -92.25939  1.000 46.14601 ? 221 ASP B CG  1 
ATOM   4520 O OD1 . ASP B 1 221 ? -75.66651  -32.56280 -93.46140  1.000 47.10532 ? 221 ASP B OD1 1 
ATOM   4521 O OD2 . ASP B 1 221 ? -75.29800  -32.81288 -91.30566  1.000 52.83652 ? 221 ASP B OD2 1 
ATOM   4522 N N   . GLU B 1 222 ? -79.21986  -29.10755 -91.70078  1.000 41.22642 ? 222 GLU B N   1 
ATOM   4523 C CA  . GLU B 1 222 ? -80.55770  -28.58002 -91.44927  1.000 33.81805 ? 222 GLU B CA  1 
ATOM   4524 C C   . GLU B 1 222 ? -81.03394  -27.70653 -92.60629  1.000 39.99222 ? 222 GLU B C   1 
ATOM   4525 O O   . GLU B 1 222 ? -82.22646  -27.70628 -92.93735  1.000 43.16062 ? 222 GLU B O   1 
ATOM   4526 C CB  . GLU B 1 222 ? -80.57487  -27.79071 -90.13667  1.000 37.64234 ? 222 GLU B CB  1 
ATOM   4527 C CG  . GLU B 1 222 ? -80.20997  -28.61506 -88.91221  1.000 38.69824 ? 222 GLU B CG  1 
ATOM   4528 C CD  . GLU B 1 222 ? -80.22178  -27.81483 -87.61602  1.000 39.94787 ? 222 GLU B CD  1 
ATOM   4529 O OE1 . GLU B 1 222 ? -79.66303  -26.69399 -87.58764  1.000 38.89998 ? 222 GLU B OE1 1 
ATOM   4530 O OE2 . GLU B 1 222 ? -80.78072  -28.31194 -86.61655  1.000 49.94343 ? 222 GLU B OE2 1 
ATOM   4531 N N   . ILE B 1 223 ? -80.12446  -26.94729 -93.22932  1.000 36.58279 ? 223 ILE B N   1 
ATOM   4532 C CA  . ILE B 1 223 ? -80.51206  -26.14588 -94.38497  1.000 36.05864 ? 223 ILE B CA  1 
ATOM   4533 C C   . ILE B 1 223 ? -80.91433  -27.05520 -95.52817  1.000 39.87000 ? 223 ILE B C   1 
ATOM   4534 O O   . ILE B 1 223 ? -81.96037  -26.86769 -96.16057  1.000 38.21083 ? 223 ILE B O   1 
ATOM   4535 C CB  . ILE B 1 223 ? -79.37857  -25.20234 -94.81538  1.000 35.53430 ? 223 ILE B CB  1 
ATOM   4536 C CG1 . ILE B 1 223 ? -79.00719  -24.24324 -93.69015  1.000 31.58641 ? 223 ILE B CG1 1 
ATOM   4537 C CG2 . ILE B 1 223 ? -79.77687  -24.45052 -96.09697  1.000 35.06639 ? 223 ILE B CG2 1 
ATOM   4538 C CD1 . ILE B 1 223 ? -77.72605  -23.47358 -93.96023  1.000 32.28922 ? 223 ILE B CD1 1 
ATOM   4539 N N   . ARG B 1 224 ? -80.08295  -28.05394 -95.81788  1.000 34.37019 ? 224 ARG B N   1 
ATOM   4540 C CA  . ARG B 1 224 ? -80.42345  -28.97010 -96.89662  1.000 40.74594 ? 224 ARG B CA  1 
ATOM   4541 C C   . ARG B 1 224 ? -81.74160  -29.68339 -96.59971  1.000 39.70348 ? 224 ARG B C   1 
ATOM   4542 O O   . ARG B 1 224 ? -82.59654  -29.81854 -97.48246  1.000 36.82388 ? 224 ARG B O   1 
ATOM   4543 C CB  . ARG B 1 224 ? -79.27943  -29.95807 -97.11683  1.000 40.29469 ? 224 ARG B CB  1 
ATOM   4544 C CG  . ARG B 1 224 ? -79.59931  -31.05894 -98.10632  1.000 39.96748 ? 224 ARG B CG  1 
ATOM   4545 C CD  . ARG B 1 224 ? -78.41113  -32.00176 -98.30346  1.000 49.98878 ? 224 ARG B CD  1 
ATOM   4546 N NE  . ARG B 1 224 ? -77.14668  -31.26503 -98.36785  1.000 54.18823 ? 224 ARG B NE  1 
ATOM   4547 C CZ  . ARG B 1 224 ? -76.42235  -31.12689 -99.47529  1.000 47.09652 ? 224 ARG B CZ  1 
ATOM   4548 N NH1 . ARG B 1 224 ? -76.82286  -31.68454 -100.60901 1.000 50.94652 ? 224 ARG B NH1 1 
ATOM   4549 N NH2 . ARG B 1 224 ? -75.29613  -30.43260 -99.44625  1.000 51.20195 ? 224 ARG B NH2 1 
ATOM   4550 N N   . ALA B 1 225 ? -81.93361  -30.10603 -95.34588  1.000 37.43350 ? 225 ALA B N   1 
ATOM   4551 C CA  . ALA B 1 225 ? -83.19314  -30.71304 -94.92797  1.000 44.18946 ? 225 ALA B CA  1 
ATOM   4552 C C   . ALA B 1 225 ? -84.37829  -29.80253 -95.22480  1.000 47.20652 ? 225 ALA B C   1 
ATOM   4553 O O   . ALA B 1 225 ? -85.38260  -30.23865 -95.79900  1.000 49.38564 ? 225 ALA B O   1 
ATOM   4554 C CB  . ALA B 1 225 ? -83.14100  -31.04201 -93.43527  1.000 39.45507 ? 225 ALA B CB  1 
ATOM   4555 N N   . ALA B 1 226 ? -84.27935  -28.52732 -94.83106  1.000 42.52818 ? 226 ALA B N   1 
ATOM   4556 C CA  . ALA B 1 226 ? -85.39581  -27.60916 -95.03253  1.000 40.78293 ? 226 ALA B CA  1 
ATOM   4557 C C   . ALA B 1 226 ? -85.66570  -27.36355 -96.51759  1.000 40.34134 ? 226 ALA B C   1 
ATOM   4558 O O   . ALA B 1 226 ? -86.82090  -27.41046 -96.95059  1.000 35.80531 ? 226 ALA B O   1 
ATOM   4559 C CB  . ALA B 1 226 ? -85.13663  -26.29551 -94.29989  1.000 33.95652 ? 226 ALA B CB  1 
ATOM   4560 N N   . ILE B 1 227 ? -84.62209  -27.10662 -97.31459  1.000 33.27770 ? 227 ILE B N   1 
ATOM   4561 C CA  . ILE B 1 227 ? -84.81365  -26.88398 -98.75294  1.000 38.80034 ? 227 ILE B CA  1 
ATOM   4562 C C   . ILE B 1 227 ? -85.59925  -28.02695 -99.37531  1.000 42.80351 ? 227 ILE B C   1 
ATOM   4563 O O   . ILE B 1 227 ? -86.55814  -27.81407 -100.12678 1.000 44.32587 ? 227 ILE B O   1 
ATOM   4564 C CB  . ILE B 1 227 ? -83.46061  -26.71176 -99.46634  1.000 38.53198 ? 227 ILE B CB  1 
ATOM   4565 C CG1 . ILE B 1 227 ? -82.66672  -25.55922 -98.85666  1.000 32.75811 ? 227 ILE B CG1 1 
ATOM   4566 C CG2 . ILE B 1 227 ? -83.67916  -26.53016 -100.97526 1.000 34.98462 ? 227 ILE B CG2 1 
ATOM   4567 C CD1 . ILE B 1 227 ? -81.59555  -25.03519 -99.75058  1.000 39.93012 ? 227 ILE B CD1 1 
ATOM   4568 N N   . GLU B 1 228 ? -85.18924  -29.26073 -99.08020  1.000 47.13410 ? 228 GLU B N   1 
ATOM   4569 C CA  . GLU B 1 228 ? -85.83613  -30.42129 -99.67970  1.000 45.79536 ? 228 GLU B CA  1 
ATOM   4570 C C   . GLU B 1 228 ? -87.25505  -30.57712 -99.16633  1.000 43.20777 ? 228 GLU B C   1 
ATOM   4571 O O   . GLU B 1 228 ? -88.18066  -30.84163 -99.94318  1.000 43.35360 ? 228 GLU B O   1 
ATOM   4572 C CB  . GLU B 1 228 ? -85.01768  -31.67498 -99.39045  1.000 42.38070 ? 228 GLU B CB  1 
ATOM   4573 C CG  . GLU B 1 228 ? -83.63114  -31.62059 -99.98884  1.000 51.56568 ? 228 GLU B CG  1 
ATOM   4574 C CD  . GLU B 1 228 ? -83.04195  -32.98739 -100.18215 1.000 54.04098 ? 228 GLU B CD  1 
ATOM   4575 O OE1 . GLU B 1 228 ? -83.39096  -33.89947 -99.39976  1.000 53.50296 ? 228 GLU B OE1 1 
ATOM   4576 O OE2 . GLU B 1 228 ? -82.23854  -33.14496 -101.12458 1.000 59.05215 ? 228 GLU B OE2 1 
ATOM   4577 N N   . ARG B 1 229 ? -87.43855  -30.40617 -97.85901  1.000 42.31437 ? 229 ARG B N   1 
ATOM   4578 C CA  . ARG B 1 229 ? -88.76661  -30.47732 -97.27289  1.000 34.30144 ? 229 ARG B CA  1 
ATOM   4579 C C   . ARG B 1 229 ? -89.71468  -29.50265 -97.96258  1.000 43.67875 ? 229 ARG B C   1 
ATOM   4580 O O   . ARG B 1 229 ? -90.75365  -29.90047 -98.49801  1.000 49.50364 ? 229 ARG B O   1 
ATOM   4581 C CB  . ARG B 1 229 ? -88.66714  -30.19088 -95.77651  1.000 43.77003 ? 229 ARG B CB  1 
ATOM   4582 C CG  . ARG B 1 229 ? -89.91287  -30.49862 -94.99116  1.000 46.11827 ? 229 ARG B CG  1 
ATOM   4583 C CD  . ARG B 1 229 ? -90.39066  -31.91145 -95.26759  1.000 47.77925 ? 229 ARG B CD  1 
ATOM   4584 N NE  . ARG B 1 229 ? -91.19370  -32.41613 -94.15834  1.000 52.11094 ? 229 ARG B NE  1 
ATOM   4585 C CZ  . ARG B 1 229 ? -92.07213  -33.40512 -94.26215  1.000 48.00291 ? 229 ARG B CZ  1 
ATOM   4586 N NH1 . ARG B 1 229 ? -92.26310  -33.99870 -95.43110  1.000 43.81151 ? 229 ARG B NH1 1 
ATOM   4587 N NH2 . ARG B 1 229 ? -92.75905  -33.79232 -93.19593  1.000 44.45102 ? 229 ARG B NH2 1 
ATOM   4588 N N   . TYR B 1 230 ? -89.34542  -28.22208 -97.99484  1.000 44.21535 ? 230 TYR B N   1 
ATOM   4589 C CA  . TYR B 1 230 ? -90.19198  -27.20667 -98.61233  1.000 44.58071 ? 230 TYR B CA  1 
ATOM   4590 C C   . TYR B 1 230 ? -90.33568  -27.43538 -100.11290 1.000 49.13595 ? 230 TYR B C   1 
ATOM   4591 O O   . TYR B 1 230 ? -91.42969  -27.26873 -100.66842 1.000 41.17262 ? 230 TYR B O   1 
ATOM   4592 C CB  . TYR B 1 230 ? -89.62081  -25.81299 -98.33991  1.000 41.39851 ? 230 TYR B CB  1 
ATOM   4593 C CG  . TYR B 1 230 ? -89.58334  -25.41679 -96.87072  1.000 30.92887 ? 230 TYR B CG  1 
ATOM   4594 C CD1 . TYR B 1 230 ? -90.61230  -25.77113 -96.00355  1.000 31.42661 ? 230 TYR B CD1 1 
ATOM   4595 C CD2 . TYR B 1 230 ? -88.52055  -24.67869 -96.36428  1.000 30.34494 ? 230 TYR B CD2 1 
ATOM   4596 C CE1 . TYR B 1 230 ? -90.58435  -25.40098 -94.67406  1.000 34.51219 ? 230 TYR B CE1 1 
ATOM   4597 C CE2 . TYR B 1 230 ? -88.47995  -24.29216 -95.03389  1.000 27.87507 ? 230 TYR B CE2 1 
ATOM   4598 C CZ  . TYR B 1 230 ? -89.50256  -24.65977 -94.18809  1.000 36.81662 ? 230 TYR B CZ  1 
ATOM   4599 O OH  . TYR B 1 230 ? -89.43867  -24.27958 -92.85798  1.000 30.70690 ? 230 TYR B OH  1 
ATOM   4600 N N   . ALA B 1 231 ? -89.24439  -27.80990 -100.78782 1.000 47.60922 ? 231 ALA B N   1 
ATOM   4601 C CA  . ALA B 1 231 ? -89.32343  -28.04308 -102.22552 1.000 44.56071 ? 231 ALA B CA  1 
ATOM   4602 C C   . ALA B 1 231 ? -90.34599  -29.12386 -102.55245 1.000 45.30171 ? 231 ALA B C   1 
ATOM   4603 O O   . ALA B 1 231 ? -91.07263  -29.02170 -103.54858 1.000 44.10733 ? 231 ALA B O   1 
ATOM   4604 C CB  . ALA B 1 231 ? -87.94887  -28.41920 -102.77792 1.000 42.78695 ? 231 ALA B CB  1 
ATOM   4605 N N   . SER B 1 232 ? -90.43392  -30.15901 -101.71270 1.000 53.30652 ? 232 SER B N   1 
ATOM   4606 C CA  . SER B 1 232 ? -91.33716  -31.27079 -101.98561 1.000 45.04081 ? 232 SER B CA  1 
ATOM   4607 C C   . SER B 1 232 ? -92.79212  -30.83142 -102.09845 1.000 49.32343 ? 232 SER B C   1 
ATOM   4608 O O   . SER B 1 232 ? -93.61102  -31.59089 -102.62892 1.000 50.45529 ? 232 SER B O   1 
ATOM   4609 C CB  . SER B 1 232 ? -91.16651  -32.34572 -100.90830 1.000 41.28360 ? 232 SER B CB  1 
ATOM   4610 O OG  . SER B 1 232 ? -91.68144  -31.92206 -99.66146  1.000 45.10249 ? 232 SER B OG  1 
ATOM   4611 N N   . LEU B 1 233 ? -93.12397  -29.61932 -101.64944 1.000 53.48801 ? 233 LEU B N   1 
ATOM   4612 C CA  . LEU B 1 233 ? -94.46389  -29.06436 -101.79401 1.000 45.78696 ? 233 LEU B CA  1 
ATOM   4613 C C   . LEU B 1 233 ? -94.74349  -28.53147 -103.19342 1.000 44.80466 ? 233 LEU B C   1 
ATOM   4614 O O   . LEU B 1 233 ? -95.89793  -28.19893 -103.48773 1.000 50.38652 ? 233 LEU B O   1 
ATOM   4615 C CB  . LEU B 1 233 ? -94.66873  -27.95138 -100.76147 1.000 41.07634 ? 233 LEU B CB  1 
ATOM   4616 C CG  . LEU B 1 233 ? -94.96270  -28.47637 -99.35022  1.000 50.48880 ? 233 LEU B CG  1 
ATOM   4617 C CD1 . LEU B 1 233 ? -95.18769  -27.35584 -98.33236  1.000 43.65513 ? 233 LEU B CD1 1 
ATOM   4618 C CD2 . LEU B 1 233 ? -96.16638  -29.42507 -99.35969  1.000 48.58084 ? 233 LEU B CD2 1 
ATOM   4619 N N   . GLY B 1 234 ? -93.73182  -28.45222 -104.05806 1.000 38.55890 ? 234 GLY B N   1 
ATOM   4620 C CA  . GLY B 1 234 ? -93.92608  -27.90572 -105.38564 1.000 37.90690 ? 234 GLY B CA  1 
ATOM   4621 C C   . GLY B 1 234 ? -93.95653  -26.39616 -105.44270 1.000 44.26302 ? 234 GLY B C   1 
ATOM   4622 O O   . GLY B 1 234 ? -94.41641  -25.83263 -106.44238 1.000 40.98163 ? 234 GLY B O   1 
ATOM   4623 N N   . VAL B 1 235 ? -93.47069  -25.72136 -104.39540 1.000 43.09898 ? 235 VAL B N   1 
ATOM   4624 C CA  . VAL B 1 235 ? -93.47699  -24.26697 -104.30120 1.000 35.50675 ? 235 VAL B CA  1 
ATOM   4625 C C   . VAL B 1 235 ? -92.14254  -23.72333 -104.78789 1.000 32.15998 ? 235 VAL B C   1 
ATOM   4626 O O   . VAL B 1 235 ? -91.11480  -24.40684 -104.76270 1.000 38.73406 ? 235 VAL B O   1 
ATOM   4627 C CB  . VAL B 1 235 ? -93.76692  -23.80577 -102.85439 1.000 40.49225 ? 235 VAL B CB  1 
ATOM   4628 C CG1 . VAL B 1 235 ? -95.23961  -23.98091 -102.51735 1.000 32.66144 ? 235 VAL B CG1 1 
ATOM   4629 C CG2 . VAL B 1 235 ? -92.88872  -24.56490 -101.86095 1.000 40.18185 ? 235 VAL B CG2 1 
ATOM   4630 N N   . VAL B 1 236 ? -92.16912  -22.48093 -105.26375 1.000 37.43796 ? 236 VAL B N   1 
ATOM   4631 C CA  . VAL B 1 236 ? -90.94741  -21.72179 -105.49420 1.000 38.69476 ? 236 VAL B CA  1 
ATOM   4632 C C   . VAL B 1 236 ? -90.30596  -21.39732 -104.14680 1.000 36.74878 ? 236 VAL B C   1 
ATOM   4633 O O   . VAL B 1 236 ? -91.00388  -21.15358 -103.15462 1.000 41.77252 ? 236 VAL B O   1 
ATOM   4634 C CB  . VAL B 1 236 ? -91.28600  -20.44960 -106.29710 1.000 38.52113 ? 236 VAL B CB  1 
ATOM   4635 C CG1 . VAL B 1 236 ? -90.10007  -19.49566 -106.39214 1.000 38.66640 ? 236 VAL B CG1 1 
ATOM   4636 C CG2 . VAL B 1 236 ? -91.77111  -20.82566 -107.68270 1.000 41.38181 ? 236 VAL B CG2 1 
ATOM   4637 N N   . LEU B 1 237 ? -88.97592  -21.41263 -104.08793 1.000 34.89915 ? 237 LEU B N   1 
ATOM   4638 C CA  . LEU B 1 237 ? -88.25559  -21.00269 -102.88517 1.000 37.53570 ? 237 LEU B CA  1 
ATOM   4639 C C   . LEU B 1 237 ? -87.48284  -19.71917 -103.14740 1.000 32.89381 ? 237 LEU B C   1 
ATOM   4640 O O   . LEU B 1 237 ? -86.71538  -19.63416 -104.11534 1.000 31.51218 ? 237 LEU B O   1 
ATOM   4641 C CB  . LEU B 1 237 ? -87.28726  -22.08315 -102.40262 1.000 33.79821 ? 237 LEU B CB  1 
ATOM   4642 C CG  . LEU B 1 237 ? -87.89761  -23.41809 -101.99078 1.000 38.81918 ? 237 LEU B CG  1 
ATOM   4643 C CD1 . LEU B 1 237 ? -86.83083  -24.31475 -101.39862 1.000 41.51070 ? 237 LEU B CD1 1 
ATOM   4644 C CD2 . LEU B 1 237 ? -88.99111  -23.17674 -100.99929 1.000 40.16684 ? 237 LEU B CD2 1 
ATOM   4645 N N   . HIS B 1 238 ? -87.67642  -18.73176 -102.27503 1.000 27.30778 ? 238 HIS B N   1 
ATOM   4646 C CA  . HIS B 1 238 ? -86.84463  -17.53783 -102.23803 1.000 28.88219 ? 238 HIS B CA  1 
ATOM   4647 C C   . HIS B 1 238 ? -86.14016  -17.46681 -100.89364 1.000 26.17652 ? 238 HIS B C   1 
ATOM   4648 O O   . HIS B 1 238 ? -86.76085  -17.69512 -99.85058  1.000 30.20535 ? 238 HIS B O   1 
ATOM   4649 C CB  . HIS B 1 238 ? -87.65509  -16.26284 -102.45306 1.000 27.88526 ? 238 HIS B CB  1 
ATOM   4650 C CG  . HIS B 1 238 ? -88.11774  -16.06431 -103.86154 1.000 33.43989 ? 238 HIS B CG  1 
ATOM   4651 N ND1 . HIS B 1 238 ? -88.76033  -14.91607 -104.27359 1.000 27.48452 ? 238 HIS B ND1 1 
ATOM   4652 C CD2 . HIS B 1 238 ? -88.05092  -16.87090 -104.94882 1.000 35.89260 ? 238 HIS B CD2 1 
ATOM   4653 C CE1 . HIS B 1 238 ? -89.05107  -15.01524 -105.56008 1.000 32.92744 ? 238 HIS B CE1 1 
ATOM   4654 N NE2 . HIS B 1 238 ? -88.63532  -16.19300 -105.99353 1.000 36.43724 ? 238 HIS B NE2 1 
ATOM   4655 N N   . ILE B 1 239 ? -84.84201  -17.18146 -100.92760 1.000 28.58366 ? 239 ILE B N   1 
ATOM   4656 C CA  . ILE B 1 239 ? -84.09322  -16.78784 -99.73831  1.000 24.94720 ? 239 ILE B CA  1 
ATOM   4657 C C   . ILE B 1 239 ? -84.28854  -15.28285 -99.62274  1.000 23.30902 ? 239 ILE B C   1 
ATOM   4658 O O   . ILE B 1 239 ? -83.83554  -14.53325 -100.48820 1.000 24.69599 ? 239 ILE B O   1 
ATOM   4659 C CB  . ILE B 1 239 ? -82.60770  -17.16229 -99.85745  1.000 27.47085 ? 239 ILE B CB  1 
ATOM   4660 C CG1 . ILE B 1 239 ? -82.46849  -18.62356 -100.27693 1.000 31.55261 ? 239 ILE B CG1 1 
ATOM   4661 C CG2 . ILE B 1 239 ? -81.84464  -16.89530 -98.54864  1.000 23.92001 ? 239 ILE B CG2 1 
ATOM   4662 C CD1 . ILE B 1 239 ? -83.07412  -19.60200 -99.28781  1.000 32.72097 ? 239 ILE B CD1 1 
ATOM   4663 N N   . THR B 1 240 ? -85.00081  -14.83537 -98.58448  1.000 19.88143 ? 240 THR B N   1 
ATOM   4664 C CA  . THR B 1 240 ? -85.53029  -13.47445 -98.66109  1.000 25.40901 ? 240 THR B CA  1 
ATOM   4665 C C   . THR B 1 240 ? -84.76518  -12.44104 -97.84192  1.000 22.19886 ? 240 THR B C   1 
ATOM   4666 O O   . THR B 1 240 ? -84.89475  -11.24522 -98.11703  1.000 22.64959 ? 240 THR B O   1 
ATOM   4667 C CB  . THR B 1 240 ? -87.01395  -13.43472 -98.26056  1.000 20.33551 ? 240 THR B CB  1 
ATOM   4668 O OG1 . THR B 1 240 ? -87.19589  -13.90053 -96.92490  1.000 21.13582 ? 240 THR B OG1 1 
ATOM   4669 C CG2 . THR B 1 240 ? -87.86277  -14.24222 -99.23274  1.000 24.92638 ? 240 THR B CG2 1 
ATOM   4670 N N   . GLY B 1 241 ? -84.03298  -12.83173 -96.81379  1.000 25.81652 ? 241 GLY B N   1 
ATOM   4671 C CA  . GLY B 1 241 ? -83.35240  -11.81543 -96.05580  1.000 25.81652 ? 241 GLY B CA  1 
ATOM   4672 C C   . GLY B 1 241 ? -82.02654  -12.28314 -95.50173  1.000 27.80661 ? 241 GLY B C   1 
ATOM   4673 O O   . GLY B 1 241 ? -81.75836  -12.13989 -94.30306  1.000 26.82497 ? 241 GLY B O   1 
ATOM   4674 N N   . LEU B 1 242 ? -81.18544  -12.83774 -96.36988  1.000 29.11652 ? 242 LEU B N   1 
ATOM   4675 C CA  . LEU B 1 242 ? -79.96907  -13.51729 -95.93100  1.000 20.91370 ? 242 LEU B CA  1 
ATOM   4676 C C   . LEU B 1 242 ? -78.98283  -12.55672 -95.24688  1.000 22.30001 ? 242 LEU B C   1 
ATOM   4677 O O   . LEU B 1 242 ? -78.71548  -11.44701 -95.73766  1.000 20.69262 ? 242 LEU B O   1 
ATOM   4678 C CB  . LEU B 1 242 ? -79.32414  -14.21155 -97.12705  1.000 23.10880 ? 242 LEU B CB  1 
ATOM   4679 C CG  . LEU B 1 242 ? -77.90570  -14.75998 -96.92623  1.000 33.71327 ? 242 LEU B CG  1 
ATOM   4680 C CD1 . LEU B 1 242 ? -77.84121  -15.92840 -95.92001  1.000 19.32816 ? 242 LEU B CD1 1 
ATOM   4681 C CD2 . LEU B 1 242 ? -77.30337  -15.14605 -98.26402  1.000 19.92025 ? 242 LEU B CD2 1 
ATOM   4682 N N   . ASP B 1 243 ? -78.49033  -12.97593 -94.07684  1.000 25.24608 ? 243 ASP B N   1 
ATOM   4683 C CA  . ASP B 1 243 ? -77.27987  -12.42173 -93.48141  1.000 21.15901 ? 243 ASP B CA  1 
ATOM   4684 C C   . ASP B 1 243 ? -76.67371  -13.46566 -92.55336  1.000 26.59748 ? 243 ASP B C   1 
ATOM   4685 O O   . ASP B 1 243 ? -77.33649  -14.42474 -92.14522  1.000 24.92380 ? 243 ASP B O   1 
ATOM   4686 C CB  . ASP B 1 243 ? -77.53411  -11.08958 -92.75212  1.000 25.36231 ? 243 ASP B CB  1 
ATOM   4687 C CG  . ASP B 1 243 ? -78.86925  -11.04934 -92.00668  1.000 25.63332 ? 243 ASP B CG  1 
ATOM   4688 O OD1 . ASP B 1 243 ? -79.29775  -12.09371 -91.47616  1.000 23.57437 ? 243 ASP B OD1 1 
ATOM   4689 O OD2 . ASP B 1 243 ? -79.48636  -9.95238  -91.93901  1.000 27.63061 ? 243 ASP B OD2 1 
ATOM   4690 N N   . VAL B 1 244 ? -75.38664  -13.29042 -92.25895  1.000 27.31471 ? 244 VAL B N   1 
ATOM   4691 C CA  . VAL B 1 244 ? -74.61897  -14.22477 -91.43637  1.000 22.24696 ? 244 VAL B CA  1 
ATOM   4692 C C   . VAL B 1 244 ? -74.05820  -13.40558 -90.27460  1.000 26.64409 ? 244 VAL B C   1 
ATOM   4693 O O   . VAL B 1 244 ? -73.03309  -12.71868 -90.41985  1.000 20.62162 ? 244 VAL B O   1 
ATOM   4694 C CB  . VAL B 1 244 ? -73.50109  -14.92851 -92.22686  1.000 28.63490 ? 244 VAL B CB  1 
ATOM   4695 C CG1 . VAL B 1 244 ? -72.64095  -15.79204 -91.30580  1.000 29.29535 ? 244 VAL B CG1 1 
ATOM   4696 C CG2 . VAL B 1 244 ? -74.05666  -15.79811 -93.33256  1.000 25.94008 ? 244 VAL B CG2 1 
ATOM   4697 N N   . SER B 1 245 ? -74.73824  -13.44970 -89.12630  1.000 23.33489 ? 245 SER B N   1 
ATOM   4698 C CA  . SER B 1 245 ? -74.33277  -12.64523 -87.98210  1.000 26.85716 ? 245 SER B CA  1 
ATOM   4699 C C   . SER B 1 245 ? -73.00299  -13.13659 -87.41797  1.000 26.29198 ? 245 SER B C   1 
ATOM   4700 O O   . SER B 1 245 ? -72.75472  -14.34146 -87.33959  1.000 22.25450 ? 245 SER B O   1 
ATOM   4701 C CB  . SER B 1 245 ? -75.39824  -12.69448 -86.89029  1.000 25.70330 ? 245 SER B CB  1 
ATOM   4702 O OG  . SER B 1 245 ? -74.95456  -12.02120 -85.72445  1.000 30.88873 ? 245 SER B OG  1 
ATOM   4703 N N   . MET B 1 246 ? -72.14269  -12.19211 -87.02922  1.000 25.71920 ? 246 MET B N   1 
ATOM   4704 C CA  . MET B 1 246 ? -70.88657  -12.55711 -86.38340  1.000 30.93887 ? 246 MET B CA  1 
ATOM   4705 C C   . MET B 1 246 ? -71.08538  -13.07287 -84.96281  1.000 34.81740 ? 246 MET B C   1 
ATOM   4706 O O   . MET B 1 246 ? -70.12044  -13.55757 -84.36447  1.000 39.32957 ? 246 MET B O   1 
ATOM   4707 C CB  . MET B 1 246 ? -69.91620  -11.36229 -86.36992  1.000 25.71857 ? 246 MET B CB  1 
ATOM   4708 C CG  . MET B 1 246 ? -69.30081  -11.01786 -87.74747  1.000 31.31179 ? 246 MET B CG  1 
ATOM   4709 S SD  . MET B 1 246 ? -68.53572  -12.42844 -88.58418  1.000 31.58119 ? 246 MET B SD  1 
ATOM   4710 C CE  . MET B 1 246 ? -67.49935  -11.57678 -89.76285  1.000 25.34336 ? 246 MET B CE  1 
ATOM   4711 N N   . PHE B 1 247 ? -72.30064  -12.99193 -84.42015  1.000 32.27697 ? 247 PHE B N   1 
ATOM   4712 C CA  . PHE B 1 247 ? -72.59801  -13.40081 -83.05338  1.000 29.33496 ? 247 PHE B CA  1 
ATOM   4713 C C   . PHE B 1 247 ? -73.69899  -14.44795 -83.06094  1.000 34.00037 ? 247 PHE B C   1 
ATOM   4714 O O   . PHE B 1 247 ? -74.69510  -14.29926 -83.77758  1.000 36.90708 ? 247 PHE B O   1 
ATOM   4715 C CB  . PHE B 1 247 ? -73.05013  -12.20752 -82.19401  1.000 27.45503 ? 247 PHE B CB  1 
ATOM   4716 C CG  . PHE B 1 247 ? -72.08829  -11.05657 -82.18111  1.000 28.39498 ? 247 PHE B CG  1 
ATOM   4717 C CD1 . PHE B 1 247 ? -70.92232  -11.10699 -81.40981  1.000 23.50893 ? 247 PHE B CD1 1 
ATOM   4718 C CD2 . PHE B 1 247 ? -72.35402  -9.90948  -82.91766  1.000 29.13186 ? 247 PHE B CD2 1 
ATOM   4719 C CE1 . PHE B 1 247 ? -70.02320  -10.02815 -81.39515  1.000 30.53233 ? 247 PHE B CE1 1 
ATOM   4720 C CE2 . PHE B 1 247 ? -71.46368  -8.81745  -82.91019  1.000 33.68163 ? 247 PHE B CE2 1 
ATOM   4721 C CZ  . PHE B 1 247 ? -70.29221  -8.87963  -82.13951  1.000 31.76888 ? 247 PHE B CZ  1 
ATOM   4722 N N   . GLU B 1 248 ? -73.52848  -15.49558 -82.25492  1.000 30.85928 ? 248 GLU B N   1 
ATOM   4723 C CA  . GLU B 1 248 ? -74.62050  -16.43123 -82.03126  1.000 35.65319 ? 248 GLU B CA  1 
ATOM   4724 C C   . GLU B 1 248 ? -75.73762  -15.73607 -81.26356  1.000 35.59735 ? 248 GLU B C   1 
ATOM   4725 O O   . GLU B 1 248 ? -75.52179  -14.73140 -80.57790  1.000 33.90638 ? 248 GLU B O   1 
ATOM   4726 C CB  . GLU B 1 248 ? -74.14321  -17.67718 -81.28515  1.000 35.01025 ? 248 GLU B CB  1 
ATOM   4727 C CG  . GLU B 1 248 ? -72.92969  -18.35825 -81.91200  1.000 34.15678 ? 248 GLU B CG  1 
ATOM   4728 C CD  . GLU B 1 248 ? -73.27157  -19.12437 -83.17050  1.000 40.38652 ? 248 GLU B CD  1 
ATOM   4729 O OE1 . GLU B 1 248 ? -74.45796  -19.46826 -83.34535  1.000 42.19550 ? 248 GLU B OE1 1 
ATOM   4730 O OE2 . GLU B 1 248 ? -72.35748  -19.37796 -83.98937  1.000 33.53784 ? 248 GLU B OE2 1 
ATOM   4731 N N   . PHE B 1 249 ? -76.95677  -16.27086 -81.40929  1.000 46.49328 ? 249 PHE B N   1 
ATOM   4732 C CA  . PHE B 1 249 ? -78.14092  -15.48156 -81.07361  1.000 51.33285 ? 249 PHE B CA  1 
ATOM   4733 C C   . PHE B 1 249 ? -78.20911  -15.16837 -79.58333  1.000 47.41839 ? 249 PHE B C   1 
ATOM   4734 O O   . PHE B 1 249 ? -78.65935  -14.08091 -79.20017  1.000 48.59038 ? 249 PHE B O   1 
ATOM   4735 C CB  . PHE B 1 249 ? -79.41436  -16.19382 -81.54569  1.000 54.96380 ? 249 PHE B CB  1 
ATOM   4736 C CG  . PHE B 1 249 ? -80.63370  -15.28963 -81.60220  1.000 67.70817 ? 249 PHE B CG  1 
ATOM   4737 C CD1 . PHE B 1 249 ? -80.91886  -14.53981 -82.74505  1.000 67.66227 ? 249 PHE B CD1 1 
ATOM   4738 C CD2 . PHE B 1 249 ? -81.49532  -15.18548 -80.50509  1.000 67.94125 ? 249 PHE B CD2 1 
ATOM   4739 C CE1 . PHE B 1 249 ? -82.04738  -13.70482 -82.79447  1.000 70.12652 ? 249 PHE B CE1 1 
ATOM   4740 C CE2 . PHE B 1 249 ? -82.61811  -14.34895 -80.54312  1.000 63.49518 ? 249 PHE B CE2 1 
ATOM   4741 C CZ  . PHE B 1 249 ? -82.89322  -13.61066 -81.68996  1.000 72.08652 ? 249 PHE B CZ  1 
ATOM   4742 N N   . HIS B 1 250 ? -77.73890  -16.08125 -78.73174  1.000 38.77708 ? 250 HIS B N   1 
ATOM   4743 C CA  . HIS B 1 250 ? -77.69116  -15.79821 -77.30101  1.000 51.41867 ? 250 HIS B CA  1 
ATOM   4744 C C   . HIS B 1 250 ? -76.49143  -14.94663 -76.88105  1.000 45.65354 ? 250 HIS B C   1 
ATOM   4745 O O   . HIS B 1 250 ? -76.41886  -14.55983 -75.71084  1.000 44.77559 ? 250 HIS B O   1 
ATOM   4746 C CB  . HIS B 1 250 ? -77.69617  -17.11006 -76.51074  1.000 48.06883 ? 250 HIS B CB  1 
ATOM   4747 C CG  . HIS B 1 250 ? -79.02184  -17.79900 -76.51469  1.000 60.33440 ? 250 HIS B CG  1 
ATOM   4748 N ND1 . HIS B 1 250 ? -80.11612  -17.30503 -75.83709  1.000 60.70167 ? 250 HIS B ND1 1 
ATOM   4749 C CD2 . HIS B 1 250 ? -79.43742  -18.93318 -77.12702  1.000 70.39323 ? 250 HIS B CD2 1 
ATOM   4750 C CE1 . HIS B 1 250 ? -81.14841  -18.10855 -76.02918  1.000 64.16142 ? 250 HIS B CE1 1 
ATOM   4751 N NE2 . HIS B 1 250 ? -80.76396  -19.10313 -76.80936  1.000 68.66618 ? 250 HIS B NE2 1 
ATOM   4752 N N   . ASP B 1 251 ? -75.56554  -14.63028 -77.79222  1.000 37.98086 ? 251 ASP B N   1 
ATOM   4753 C CA  . ASP B 1 251 ? -74.32882  -13.91960 -77.45330  1.000 32.17588 ? 251 ASP B CA  1 
ATOM   4754 C C   . ASP B 1 251 ? -74.56535  -12.41130 -77.52953  1.000 34.45529 ? 251 ASP B C   1 
ATOM   4755 O O   . ASP B 1 251 ? -74.54596  -11.81720 -78.60912  1.000 33.89902 ? 251 ASP B O   1 
ATOM   4756 C CB  . ASP B 1 251 ? -73.19725  -14.35751 -78.38070  1.000 38.55531 ? 251 ASP B CB  1 
ATOM   4757 C CG  . ASP B 1 251 ? -71.85861  -13.66750 -78.06651  1.000 38.27854 ? 251 ASP B CG  1 
ATOM   4758 O OD1 . ASP B 1 251 ? -71.78854  -12.86184 -77.10777  1.000 38.51135 ? 251 ASP B OD1 1 
ATOM   4759 O OD2 . ASP B 1 251 ? -70.87249  -13.92432 -78.79801  1.000 31.12229 ? 251 ASP B OD2 1 
ATOM   4760 N N   . ARG B 1 252 ? -74.75186  -11.77159 -76.37650  1.000 36.84139 ? 252 ARG B N   1 
ATOM   4761 C CA  . ARG B 1 252 ? -75.09241  -10.35553 -76.33970  1.000 35.35313 ? 252 ARG B CA  1 
ATOM   4762 C C   . ARG B 1 252 ? -73.89727  -9.47363  -75.97807  1.000 36.29474 ? 252 ARG B C   1 
ATOM   4763 O O   . ARG B 1 252 ? -74.07474  -8.36307  -75.46593  1.000 31.88604 ? 252 ARG B O   1 
ATOM   4764 C CB  . ARG B 1 252 ? -76.26722  -10.11781 -75.38522  1.000 35.04842 ? 252 ARG B CB  1 
ATOM   4765 C CG  . ARG B 1 252 ? -76.20744  -10.85557 -74.05834  1.000 37.82217 ? 252 ARG B CG  1 
ATOM   4766 C CD  . ARG B 1 252 ? -77.31077  -10.34685 -73.12873  1.000 45.49802 ? 252 ARG B CD  1 
ATOM   4767 N NE  . ARG B 1 252 ? -77.28027  -10.98251 -71.81108  1.000 50.95652 ? 252 ARG B NE  1 
ATOM   4768 C CZ  . ARG B 1 252 ? -77.97967  -12.06008 -71.46890  1.000 46.56652 ? 252 ARG B CZ  1 
ATOM   4769 N NH1 . ARG B 1 252 ? -78.79249  -12.64091 -72.34617  1.000 48.62652 ? 252 ARG B NH1 1 
ATOM   4770 N NH2 . ARG B 1 252 ? -77.86893  -12.55115 -70.23902  1.000 48.51652 ? 252 ARG B NH2 1 
ATOM   4771 N N   . ARG B 1 253 ? -72.68229  -9.92703  -76.28323  1.000 29.26849 ? 253 ARG B N   1 
ATOM   4772 C CA  . ARG B 1 253 ? -71.48513  -9.16367  -75.95013  1.000 34.30472 ? 253 ARG B CA  1 
ATOM   4773 C C   . ARG B 1 253 ? -71.38582  -7.88758  -76.77886  1.000 37.06828 ? 253 ARG B C   1 
ATOM   4774 O O   . ARG B 1 253 ? -71.78838  -7.84195  -77.94082  1.000 38.83074 ? 253 ARG B O   1 
ATOM   4775 C CB  . ARG B 1 253 ? -70.24055  -10.01602 -76.16967  1.000 33.39432 ? 253 ARG B CB  1 
ATOM   4776 C CG  . ARG B 1 253 ? -69.86675  -10.22703 -77.62780  1.000 32.72861 ? 253 ARG B CG  1 
ATOM   4777 C CD  . ARG B 1 253 ? -68.73703  -11.25446 -77.75521  1.000 35.39988 ? 253 ARG B CD  1 
ATOM   4778 N NE  . ARG B 1 253 ? -67.53642  -10.81279 -77.04625  1.000 29.14226 ? 253 ARG B NE  1 
ATOM   4779 C CZ  . ARG B 1 253 ? -66.54721  -11.61935 -76.66455  1.000 38.85747 ? 253 ARG B CZ  1 
ATOM   4780 N NH1 . ARG B 1 253 ? -66.60472  -12.91928 -76.93172  1.000 31.21192 ? 253 ARG B NH1 1 
ATOM   4781 N NH2 . ARG B 1 253 ? -65.50649  -11.12729 -75.99146  1.000 32.27799 ? 253 ARG B NH2 1 
ATOM   4782 N N   . THR B 1 254 ? -70.81775  -6.84468  -76.17513  1.000 33.60150 ? 254 THR B N   1 
ATOM   4783 C CA  . THR B 1 254 ? -70.75333  -5.52425  -76.79545  1.000 31.06064 ? 254 THR B CA  1 
ATOM   4784 C C   . THR B 1 254 ? -69.32841  -4.98191  -76.86861  1.000 32.21372 ? 254 THR B C   1 
ATOM   4785 O O   . THR B 1 254 ? -69.13029  -3.78916  -77.13961  1.000 34.07316 ? 254 THR B O   1 
ATOM   4786 C CB  . THR B 1 254 ? -71.65284  -4.53620  -76.04457  1.000 37.13667 ? 254 THR B CB  1 
ATOM   4787 O OG1 . THR B 1 254 ? -71.23129  -4.42919  -74.67510  1.000 39.57018 ? 254 THR B OG1 1 
ATOM   4788 C CG2 . THR B 1 254 ? -73.11709  -4.98491  -76.08912  1.000 28.24410 ? 254 THR B CG2 1 
ATOM   4789 N N   . ASP B 1 255 ? -68.32681  -5.83346  -76.66922  1.000 28.19505 ? 255 ASP B N   1 
ATOM   4790 C CA  . ASP B 1 255 ? -66.95487  -5.36171  -76.51146  1.000 40.07890 ? 255 ASP B CA  1 
ATOM   4791 C C   . ASP B 1 255 ? -66.18266  -5.25613  -77.81655  1.000 41.51652 ? 255 ASP B C   1 
ATOM   4792 O O   . ASP B 1 255 ? -65.11887  -4.62760  -77.82465  1.000 40.07522 ? 255 ASP B O   1 
ATOM   4793 C CB  . ASP B 1 255 ? -66.17512  -6.26400  -75.53813  1.000 24.92234 ? 255 ASP B CB  1 
ATOM   4794 C CG  . ASP B 1 255 ? -66.13220  -7.70870  -75.97421  1.000 36.32690 ? 255 ASP B CG  1 
ATOM   4795 O OD1 . ASP B 1 255 ? -67.20976  -8.26760  -76.28631  1.000 37.00179 ? 255 ASP B OD1 1 
ATOM   4796 O OD2 . ASP B 1 255 ? -65.02764  -8.30100  -75.97738  1.000 34.99436 ? 255 ASP B OD2 1 
ATOM   4797 N N   . LEU B 1 256 ? -66.68433  -5.82878  -78.91214  1.000 49.42652 ? 256 LEU B N   1 
ATOM   4798 C CA  . LEU B 1 256 ? -65.92758  -5.89743  -80.15959  1.000 39.52296 ? 256 LEU B CA  1 
ATOM   4799 C C   . LEU B 1 256 ? -66.21954  -4.67258  -81.00846  1.000 32.62156 ? 256 LEU B C   1 
ATOM   4800 O O   . LEU B 1 256 ? -67.37122  -4.43180  -81.37991  1.000 39.71298 ? 256 LEU B O   1 
ATOM   4801 C CB  . LEU B 1 256 ? -66.25147  -7.17640  -80.92677  1.000 32.60880 ? 256 LEU B CB  1 
ATOM   4802 C CG  . LEU B 1 256 ? -65.72213  -8.36823  -80.12627  1.000 45.65652 ? 256 LEU B CG  1 
ATOM   4803 C CD1 . LEU B 1 256 ? -66.26330  -9.67522  -80.65714  1.000 43.03306 ? 256 LEU B CD1 1 
ATOM   4804 C CD2 . LEU B 1 256 ? -64.19464  -8.36948  -80.07680  1.000 42.35652 ? 256 LEU B CD2 1 
ATOM   4805 N N   . ALA B 1 257 ? -65.17716  -3.89387  -81.29825  1.000 33.66652 ? 257 ALA B N   1 
ATOM   4806 C CA  . ALA B 1 257 ? -65.29083  -2.71341  -82.14417  1.000 33.08581 ? 257 ALA B CA  1 
ATOM   4807 C C   . ALA B 1 257 ? -65.01588  -3.01574  -83.61208  1.000 34.65564 ? 257 ALA B C   1 
ATOM   4808 O O   . ALA B 1 257 ? -65.26946  -2.16735  -84.47382  1.000 34.71860 ? 257 ALA B O   1 
ATOM   4809 C CB  . ALA B 1 257 ? -64.32629  -1.62715  -81.66068  1.000 38.84039 ? 257 ALA B CB  1 
ATOM   4810 N N   . ALA B 1 258 ? -64.49293  -4.19831  -83.90318  1.000 29.32773 ? 258 ALA B N   1 
ATOM   4811 C CA  . ALA B 1 258 ? -64.20108  -4.67802  -85.23830  1.000 27.49453 ? 258 ALA B CA  1 
ATOM   4812 C C   . ALA B 1 258 ? -64.31517  -6.18491  -85.16563  1.000 31.41250 ? 258 ALA B C   1 
ATOM   4813 O O   . ALA B 1 258 ? -64.17708  -6.75880  -84.07767  1.000 35.87520 ? 258 ALA B O   1 
ATOM   4814 C CB  . ALA B 1 258 ? -62.79496  -4.27208  -85.70915  1.000 27.87010 ? 258 ALA B CB  1 
ATOM   4815 N N   . PRO B 1 259 ? -64.60019  -6.84958  -86.27756  1.000 34.34943 ? 259 PRO B N   1 
ATOM   4816 C CA  . PRO B 1 259 ? -64.63451  -8.31193  -86.25110  1.000 28.56671 ? 259 PRO B CA  1 
ATOM   4817 C C   . PRO B 1 259 ? -63.23264  -8.88524  -86.12461  1.000 30.04386 ? 259 PRO B C   1 
ATOM   4818 O O   . PRO B 1 259 ? -62.26255  -8.33139  -86.64483  1.000 36.65066 ? 259 PRO B O   1 
ATOM   4819 C CB  . PRO B 1 259 ? -65.27665  -8.68365  -87.58900  1.000 22.84459 ? 259 PRO B CB  1 
ATOM   4820 C CG  . PRO B 1 259 ? -64.99763  -7.50724  -88.48810  1.000 25.37120 ? 259 PRO B CG  1 
ATOM   4821 C CD  . PRO B 1 259 ? -64.93616  -6.29305  -87.60045  1.000 23.77361 ? 259 PRO B CD  1 
ATOM   4822 N N   . THR B 1 260 ? -63.13297  -10.00251 -85.41563  1.000 35.96382 ? 260 THR B N   1 
ATOM   4823 C CA  . THR B 1 260 ? -61.86196  -10.68687 -85.28462  1.000 33.60949 ? 260 THR B CA  1 
ATOM   4824 C C   . THR B 1 260 ? -61.52193  -11.38957 -86.58750  1.000 38.81710 ? 260 THR B C   1 
ATOM   4825 O O   . THR B 1 260 ? -62.39759  -11.69352 -87.40123  1.000 34.24715 ? 260 THR B O   1 
ATOM   4826 C CB  . THR B 1 260 ? -61.90990  -11.72246 -84.16222  1.000 32.65704 ? 260 THR B CB  1 
ATOM   4827 O OG1 . THR B 1 260 ? -62.71210  -12.83604 -84.58190  1.000 32.26697 ? 260 THR B OG1 1 
ATOM   4828 C CG2 . THR B 1 260 ? -62.49754  -11.11882 -82.88164  1.000 33.66267 ? 260 THR B CG2 1 
ATOM   4829 N N   . SER B 1 261 ? -60.23088  -11.67944 -86.76030  1.000 29.25621 ? 261 SER B N   1 
ATOM   4830 C CA  . SER B 1 261 ? -59.80430  -12.43416 -87.92891  1.000 32.70472 ? 261 SER B CA  1 
ATOM   4831 C C   . SER B 1 261 ? -60.50974  -13.78040 -87.98071  1.000 29.95507 ? 261 SER B C   1 
ATOM   4832 O O   . SER B 1 261 ? -60.79450  -14.29359 -89.06635  1.000 31.73633 ? 261 SER B O   1 
ATOM   4833 C CB  . SER B 1 261 ? -58.27311  -12.59865 -87.93270  1.000 28.68100 ? 261 SER B CB  1 
ATOM   4834 O OG  . SER B 1 261 ? -57.85154  -13.53781 -86.96031  1.000 38.50278 ? 261 SER B OG  1 
ATOM   4835 N N   . GLU B 1 262 ? -60.81416  -14.37401 -86.81465  1.000 26.57468 ? 262 GLU B N   1 
ATOM   4836 C CA  . GLU B 1 262 ? -61.51622  -15.65681 -86.81110  1.000 38.25326 ? 262 GLU B CA  1 
ATOM   4837 C C   . GLU B 1 262 ? -62.96074  -15.49978 -87.28048  1.000 38.65652 ? 262 GLU B C   1 
ATOM   4838 O O   . GLU B 1 262 ? -63.50027  -16.38060 -87.96894  1.000 31.87850 ? 262 GLU B O   1 
ATOM   4839 C CB  . GLU B 1 262 ? -61.48227  -16.29747 -85.41871  1.000 40.40779 ? 262 GLU B CB  1 
ATOM   4840 C CG  . GLU B 1 262 ? -62.22156  -17.64685 -85.34360  1.000 46.36652 ? 262 GLU B CG  1 
ATOM   4841 C CD  . GLU B 1 262 ? -61.42370  -18.80436 -85.93626  1.000 68.95704 ? 262 GLU B CD  1 
ATOM   4842 O OE1 . GLU B 1 262 ? -60.23607  -18.95523 -85.56969  1.000 69.22930 ? 262 GLU B OE1 1 
ATOM   4843 O OE2 . GLU B 1 262 ? -61.99061  -19.57334 -86.74748  1.000 73.01652 ? 262 GLU B OE2 1 
ATOM   4844 N N   . MET B 1 263 ? -63.60762  -14.38013 -86.91739  1.000 28.86904 ? 263 MET B N   1 
ATOM   4845 C CA  . MET B 1 263 ? -64.95683  -14.10334 -87.40817  1.000 30.85072 ? 263 MET B CA  1 
ATOM   4846 C C   . MET B 1 263 ? -64.94455  -13.94087 -88.91876  1.000 29.04327 ? 263 MET B C   1 
ATOM   4847 O O   . MET B 1 263 ? -65.64284  -14.66967 -89.62918  1.000 25.61134 ? 263 MET B O   1 
ATOM   4848 C CB  . MET B 1 263 ? -65.54265  -12.86172 -86.71787  1.000 32.04638 ? 263 MET B CB  1 
ATOM   4849 C CG  . MET B 1 263 ? -65.74771  -13.06659 -85.22393  1.000 35.27483 ? 263 MET B CG  1 
ATOM   4850 S SD  . MET B 1 263 ? -66.86927  -11.94488 -84.37460  1.000 42.63526 ? 263 MET B SD  1 
ATOM   4851 C CE  . MET B 1 263 ? -65.89784  -10.51510 -84.05550  1.000 47.64652 ? 263 MET B CE  1 
ATOM   4852 N N   . ILE B 1 264 ? -64.06502  -13.06380 -89.43033  1.000 30.04840 ? 264 ILE B N   1 
ATOM   4853 C CA  . ILE B 1 264 ? -63.94070  -12.83933 -90.87008  1.000 25.77913 ? 264 ILE B CA  1 
ATOM   4854 C C   . ILE B 1 264 ? -63.68831  -14.14763 -91.61953  1.000 31.87447 ? 264 ILE B C   1 
ATOM   4855 O O   . ILE B 1 264 ? -64.33665  -14.42624 -92.63743  1.000 37.39397 ? 264 ILE B O   1 
ATOM   4856 C CB  . ILE B 1 264 ? -62.84668  -11.80143 -91.15673  1.000 26.94927 ? 264 ILE B CB  1 
ATOM   4857 C CG1 . ILE B 1 264 ? -63.28135  -10.42720 -90.65590  1.000 20.18555 ? 264 ILE B CG1 1 
ATOM   4858 C CG2 . ILE B 1 264 ? -62.56905  -11.74879 -92.65322  1.000 25.91540 ? 264 ILE B CG2 1 
ATOM   4859 C CD1 . ILE B 1 264 ? -64.44153  -9.86597  -91.43272  1.000 26.80130 ? 264 ILE B CD1 1 
ATOM   4860 N N   . GLU B 1 265 ? -62.78679  -14.99255 -91.11703  1.000 26.18166 ? 265 GLU B N   1 
ATOM   4861 C CA  . GLU B 1 265 ? -62.42483  -16.19371 -91.87208  1.000 26.40532 ? 265 GLU B CA  1 
ATOM   4862 C C   . GLU B 1 265 ? -63.49692  -17.27280 -91.79852  1.000 27.71403 ? 265 GLU B C   1 
ATOM   4863 O O   . GLU B 1 265 ? -63.75829  -17.96247 -92.78957  1.000 28.13794 ? 265 GLU B O   1 
ATOM   4864 C CB  . GLU B 1 265 ? -61.08976  -16.75130 -91.37522  1.000 28.36932 ? 265 GLU B CB  1 
ATOM   4865 C CG  . GLU B 1 265 ? -59.89802  -15.85865 -91.68422  1.000 31.82565 ? 265 GLU B CG  1 
ATOM   4866 C CD  . GLU B 1 265 ? -58.66594  -16.25012 -90.90030  1.000 36.20211 ? 265 GLU B CD  1 
ATOM   4867 O OE1 . GLU B 1 265 ? -58.66045  -17.35290 -90.30618  1.000 35.95741 ? 265 GLU B OE1 1 
ATOM   4868 O OE2 . GLU B 1 265 ? -57.71399  -15.45019 -90.88724  1.000 37.36312 ? 265 GLU B OE2 1 
ATOM   4869 N N   . ARG B 1 266 ? -64.10602  -17.45777 -90.63171  1.000 33.53702 ? 266 ARG B N   1 
ATOM   4870 C CA  . ARG B 1 266 ? -65.22164  -18.39281 -90.53632  1.000 31.36835 ? 266 ARG B CA  1 
ATOM   4871 C C   . ARG B 1 266 ? -66.43549  -17.89231 -91.32649  1.000 30.64558 ? 266 ARG B C   1 
ATOM   4872 O O   . ARG B 1 266 ? -67.13175  -18.68974 -91.96942  1.000 26.67786 ? 266 ARG B O   1 
ATOM   4873 C CB  . ARG B 1 266 ? -65.57119  -18.62285 -89.06463  1.000 30.80848 ? 266 ARG B CB  1 
ATOM   4874 C CG  . ARG B 1 266 ? -66.81636  -19.47057 -88.82753  1.000 42.29148 ? 266 ARG B CG  1 
ATOM   4875 C CD  . ARG B 1 266 ? -66.82315  -20.76443 -89.65498  1.000 39.40326 ? 266 ARG B CD  1 
ATOM   4876 N NE  . ARG B 1 266 ? -68.03473  -21.53742 -89.39710  1.000 37.55652 ? 266 ARG B NE  1 
ATOM   4877 C CZ  . ARG B 1 266 ? -68.62301  -22.33832 -90.28396  1.000 49.04652 ? 266 ARG B CZ  1 
ATOM   4878 N NH1 . ARG B 1 266 ? -68.11063  -22.48352 -91.50310  1.000 44.53634 ? 266 ARG B NH1 1 
ATOM   4879 N NH2 . ARG B 1 266 ? -69.73340  -22.99394 -89.95575  1.000 42.28098 ? 266 ARG B NH2 1 
ATOM   4880 N N   . GLN B 1 267 ? -66.70462  -16.57937 -91.30096  1.000 23.00084 ? 267 GLN B N   1 
ATOM   4881 C CA  . GLN B 1 267 ? -67.80941  -16.05938 -92.10736  1.000 30.25464 ? 267 GLN B CA  1 
ATOM   4882 C C   . GLN B 1 267 ? -67.58812  -16.36888 -93.57596  1.000 30.96963 ? 267 GLN B C   1 
ATOM   4883 O O   . GLN B 1 267 ? -68.52370  -16.75463 -94.28145  1.000 29.86820 ? 267 GLN B O   1 
ATOM   4884 C CB  . GLN B 1 267 ? -67.97770  -14.55270 -91.91401  1.000 30.38968 ? 267 GLN B CB  1 
ATOM   4885 C CG  . GLN B 1 267 ? -69.23733  -13.99179 -92.60185  1.000 24.49897 ? 267 GLN B CG  1 
ATOM   4886 C CD  . GLN B 1 267 ? -69.32122  -12.47444 -92.54149  1.000 22.72923 ? 267 GLN B CD  1 
ATOM   4887 O OE1 . GLN B 1 267 ? -68.43555  -11.77249 -93.04209  1.000 27.63869 ? 267 GLN B OE1 1 
ATOM   4888 N NE2 . GLN B 1 267 ? -70.38474  -11.95839 -91.92708  1.000 26.17317 ? 267 GLN B NE2 1 
ATOM   4889 N N   . ALA B 1 268 ? -66.33741  -16.24522 -94.03329  1.000 31.41615 ? 268 ALA B N   1 
ATOM   4890 C CA  . ALA B 1 268 ? -65.99549  -16.51126 -95.42608  1.000 26.90868 ? 268 ALA B CA  1 
ATOM   4891 C C   . ALA B 1 268 ? -66.26713  -17.96325 -95.78689  1.000 25.10957 ? 268 ALA B C   1 
ATOM   4892 O O   . ALA B 1 268 ? -66.85299  -18.25991 -96.83973  1.000 28.00660 ? 268 ALA B O   1 
ATOM   4893 C CB  . ALA B 1 268 ? -64.52466  -16.15464 -95.67523  1.000 26.61567 ? 268 ALA B CB  1 
ATOM   4894 N N   . GLU B 1 269 ? -65.83707  -18.88636 -94.92318  1.000 34.18146 ? 269 GLU B N   1 
ATOM   4895 C CA  . GLU B 1 269 ? -66.12435  -20.30225 -95.13524  1.000 33.26935 ? 269 GLU B CA  1 
ATOM   4896 C C   . GLU B 1 269 ? -67.62293  -20.55944 -95.10144  1.000 30.25499 ? 269 GLU B C   1 
ATOM   4897 O O   . GLU B 1 269 ? -68.15741  -21.29381 -95.94152  1.000 32.90508 ? 269 GLU B O   1 
ATOM   4898 C CB  . GLU B 1 269 ? -65.40359  -21.14088 -94.07255  1.000 31.47818 ? 269 GLU B CB  1 
ATOM   4899 C CG  . GLU B 1 269 ? -65.70037  -22.63969 -94.15558  1.000 37.47390 ? 269 GLU B CG  1 
ATOM   4900 C CD  . GLU B 1 269 ? -65.02552  -23.45453 -93.05036  1.000 45.05519 ? 269 GLU B CD  1 
ATOM   4901 O OE1 . GLU B 1 269 ? -65.13659  -23.08968 -91.85395  1.000 45.05712 ? 269 GLU B OE1 1 
ATOM   4902 O OE2 . GLU B 1 269 ? -64.37892  -24.46952 -93.39412  1.000 50.43139 ? 269 GLU B OE2 1 
ATOM   4903 N N   . ARG B 1 270 ? -68.31699  -19.94163 -94.14185  1.000 31.90979 ? 270 ARG B N   1 
ATOM   4904 C CA  . ARG B 1 270 ? -69.75741  -20.13571 -93.99998  1.000 32.71796 ? 270 ARG B CA  1 
ATOM   4905 C C   . ARG B 1 270 ? -70.49743  -19.65957 -95.24387  1.000 32.29080 ? 270 ARG B C   1 
ATOM   4906 O O   . ARG B 1 270 ? -71.37070  -20.35981 -95.77066  1.000 27.13862 ? 270 ARG B O   1 
ATOM   4907 C CB  . ARG B 1 270 ? -70.25164  -19.40284 -92.75225  1.000 31.50277 ? 270 ARG B CB  1 
ATOM   4908 C CG  . ARG B 1 270 ? -71.75531  -19.38273 -92.56939  1.000 27.86702 ? 270 ARG B CG  1 
ATOM   4909 C CD  . ARG B 1 270 ? -72.30287  -20.74660 -92.20176  1.000 29.58854 ? 270 ARG B CD  1 
ATOM   4910 N NE  . ARG B 1 270 ? -73.44173  -20.58981 -91.30710  1.000 31.20443 ? 270 ARG B NE  1 
ATOM   4911 C CZ  . ARG B 1 270 ? -74.35604  -21.52390 -91.06233  1.000 32.43530 ? 270 ARG B CZ  1 
ATOM   4912 N NH1 . ARG B 1 270 ? -74.27480  -22.71494 -91.63483  1.000 33.92088 ? 270 ARG B NH1 1 
ATOM   4913 N NH2 . ARG B 1 270 ? -75.36349  -21.25882 -90.24758  1.000 31.88559 ? 270 ARG B NH2 1 
ATOM   4914 N N   . TYR B 1 271 ? -70.15286  -18.47394 -95.74304  1.000 29.75491 ? 271 TYR B N   1 
ATOM   4915 C CA  . TYR B 1 271 ? -70.82763  -18.00098 -96.94730  1.000 27.48122 ? 271 TYR B CA  1 
ATOM   4916 C C   . TYR B 1 271 ? -70.48444  -18.86686 -98.15330  1.000 34.17841 ? 271 TYR B C   1 
ATOM   4917 O O   . TYR B 1 271 ? -71.33862  -19.07194 -99.02856  1.000 30.13457 ? 271 TYR B O   1 
ATOM   4918 C CB  . TYR B 1 271 ? -70.46637  -16.54576 -97.20782  1.000 23.30298 ? 271 TYR B CB  1 
ATOM   4919 C CG  . TYR B 1 271 ? -71.49039  -15.53003 -96.73250  1.000 29.04846 ? 271 TYR B CG  1 
ATOM   4920 C CD1 . TYR B 1 271 ? -72.78644  -15.49208 -97.26481  1.000 29.99238 ? 271 TYR B CD1 1 
ATOM   4921 C CD2 . TYR B 1 271 ? -71.15211  -14.58990 -95.76963  1.000 26.77977 ? 271 TYR B CD2 1 
ATOM   4922 C CE1 . TYR B 1 271 ? -73.71624  -14.52945 -96.83853  1.000 24.48153 ? 271 TYR B CE1 1 
ATOM   4923 C CE2 . TYR B 1 271 ? -72.06450  -13.63547 -95.33142  1.000 23.99560 ? 271 TYR B CE2 1 
ATOM   4924 C CZ  . TYR B 1 271 ? -73.33775  -13.60211 -95.87168  1.000 24.99651 ? 271 TYR B CZ  1 
ATOM   4925 O OH  . TYR B 1 271 ? -74.21108  -12.63677 -95.42381  1.000 26.14648 ? 271 TYR B OH  1 
ATOM   4926 N N   . GLY B 1 272 ? -69.25189  -19.39319 -98.21166  1.000 33.75898 ? 272 GLY B N   1 
ATOM   4927 C CA  . GLY B 1 272 ? -68.89850  -20.30145 -99.29196  1.000 27.09860 ? 272 GLY B CA  1 
ATOM   4928 C C   . GLY B 1 272 ? -69.74162  -21.55991 -99.27222  1.000 32.86193 ? 272 GLY B C   1 
ATOM   4929 O O   . GLY B 1 272 ? -70.28367  -21.97851 -100.29905 1.000 36.56409 ? 272 GLY B O   1 
ATOM   4930 N N   . GLN B 1 273 ? -69.89042  -22.16210 -98.08915  1.000 34.77288 ? 273 GLN B N   1 
ATOM   4931 C CA  . GLN B 1 273 ? -70.72090  -23.35444 -97.95267  1.000 33.75083 ? 273 GLN B CA  1 
ATOM   4932 C C   . GLN B 1 273 ? -72.18468  -23.05046 -98.23767  1.000 38.27251 ? 273 GLN B C   1 
ATOM   4933 O O   . GLN B 1 273 ? -72.88378  -23.86058 -98.85881  1.000 35.90657 ? 273 GLN B O   1 
ATOM   4934 C CB  . GLN B 1 273 ? -70.56145  -23.93765 -96.54783  1.000 36.14378 ? 273 GLN B CB  1 
ATOM   4935 C CG  . GLN B 1 273 ? -69.13043  -24.32756 -96.20715  1.000 35.26381 ? 273 GLN B CG  1 
ATOM   4936 C CD  . GLN B 1 273 ? -68.94646  -24.69106 -94.74274  1.000 40.07540 ? 273 GLN B CD  1 
ATOM   4937 O OE1 . GLN B 1 273 ? -69.28663  -23.92099 -93.84008  1.000 42.97697 ? 273 GLN B OE1 1 
ATOM   4938 N NE2 . GLN B 1 273 ? -68.40003  -25.87330 -94.50125  1.000 52.29959 ? 273 GLN B NE2 1 
ATOM   4939 N N   . ILE B 1 274 ? -72.67199  -21.89545 -97.77995  1.000 38.20910 ? 274 ILE B N   1 
ATOM   4940 C CA  . ILE B 1 274 ? -74.07049  -21.53050 -98.01329  1.000 35.45844 ? 274 ILE B CA  1 
ATOM   4941 C C   . ILE B 1 274 ? -74.35275  -21.44231 -99.50695  1.000 33.51677 ? 274 ILE B C   1 
ATOM   4942 O O   . ILE B 1 274 ? -75.31436  -22.03579 -100.01896 1.000 30.96988 ? 274 ILE B O   1 
ATOM   4943 C CB  . ILE B 1 274 ? -74.40588  -20.20615 -97.30446  1.000 30.59941 ? 274 ILE B CB  1 
ATOM   4944 C CG1 . ILE B 1 274 ? -74.54234  -20.41461 -95.79691  1.000 26.59532 ? 274 ILE B CG1 1 
ATOM   4945 C CG2 . ILE B 1 274 ? -75.66905  -19.59163 -97.88775  1.000 24.15498 ? 274 ILE B CG2 1 
ATOM   4946 C CD1 . ILE B 1 274 ? -74.59687  -19.11308 -95.03821  1.000 27.83175 ? 274 ILE B CD1 1 
ATOM   4947 N N   . PHE B 1 275 ? -73.51315  -20.70540 -100.23501 1.000 30.40023 ? 275 PHE B N   1 
ATOM   4948 C CA  . PHE B 1 275 ? -73.81228  -20.49664 -101.64492 1.000 37.45961 ? 275 PHE B CA  1 
ATOM   4949 C C   . PHE B 1 275 ? -73.53384  -21.72648 -102.49186 1.000 37.46901 ? 275 PHE B C   1 
ATOM   4950 O O   . PHE B 1 275 ? -74.21216  -21.93150 -103.50312 1.000 33.85199 ? 275 PHE B O   1 
ATOM   4951 C CB  . PHE B 1 275 ? -73.05408  -19.28762 -102.15839 1.000 25.91028 ? 275 PHE B CB  1 
ATOM   4952 C CG  . PHE B 1 275 ? -73.80629  -18.02180 -101.96190 1.000 29.92692 ? 275 PHE B CG  1 
ATOM   4953 C CD1 . PHE B 1 275 ? -74.77216  -17.63425 -102.87856 1.000 30.68992 ? 275 PHE B CD1 1 
ATOM   4954 C CD2 . PHE B 1 275 ? -73.60060  -17.25110 -100.82721 1.000 26.36530 ? 275 PHE B CD2 1 
ATOM   4955 C CE1 . PHE B 1 275 ? -75.49344  -16.47994 -102.69558 1.000 30.99913 ? 275 PHE B CE1 1 
ATOM   4956 C CE2 . PHE B 1 275 ? -74.31693  -16.09348 -100.63657 1.000 31.95962 ? 275 PHE B CE2 1 
ATOM   4957 C CZ  . PHE B 1 275 ? -75.26850  -15.70610 -101.57157 1.000 34.87958 ? 275 PHE B CZ  1 
ATOM   4958 N N   . ALA B 1 276 ? -72.55363  -22.54593 -102.10276 1.000 40.51031 ? 276 ALA B N   1 
ATOM   4959 C CA  . ALA B 1 276 ? -72.40721  -23.85940 -102.71716 1.000 37.81352 ? 276 ALA B CA  1 
ATOM   4960 C C   . ALA B 1 276 ? -73.68421  -24.67057 -102.55160 1.000 33.18218 ? 276 ALA B C   1 
ATOM   4961 O O   . ALA B 1 276 ? -74.13002  -25.35183 -103.48441 1.000 37.91991 ? 276 ALA B O   1 
ATOM   4962 C CB  . ALA B 1 276 ? -71.21208  -24.59833 -102.10480 1.000 33.19042 ? 276 ALA B CB  1 
ATOM   4963 N N   . LEU B 1 277 ? -74.30078  -24.59273 -101.37457 1.000 37.19987 ? 277 LEU B N   1 
ATOM   4964 C CA  . LEU B 1 277 ? -75.53431  -25.33765 -101.14778 1.000 37.91971 ? 277 LEU B CA  1 
ATOM   4965 C C   . LEU B 1 277 ? -76.68674  -24.77596 -101.97850 1.000 40.70143 ? 277 LEU B C   1 
ATOM   4966 O O   . LEU B 1 277 ? -77.47957  -25.54037 -102.54633 1.000 41.12610 ? 277 LEU B O   1 
ATOM   4967 C CB  . LEU B 1 277 ? -75.87289  -25.33396 -99.66140  1.000 38.81568 ? 277 LEU B CB  1 
ATOM   4968 C CG  . LEU B 1 277 ? -77.05283  -26.23097 -99.33405  1.000 45.22947 ? 277 LEU B CG  1 
ATOM   4969 C CD1 . LEU B 1 277 ? -76.76346  -27.62302 -99.84124  1.000 49.59409 ? 277 LEU B CD1 1 
ATOM   4970 C CD2 . LEU B 1 277 ? -77.29397  -26.24138 -97.84683  1.000 43.61042 ? 277 LEU B CD2 1 
ATOM   4971 N N   . PHE B 1 278 ? -76.77853  -23.44587 -102.08889 1.000 40.72793 ? 278 PHE B N   1 
ATOM   4972 C CA  . PHE B 1 278 ? -77.82512  -22.83965 -102.91553 1.000 41.32975 ? 278 PHE B CA  1 
ATOM   4973 C C   . PHE B 1 278 ? -77.67243  -23.23221 -104.38383 1.000 41.26308 ? 278 PHE B C   1 
ATOM   4974 O O   . PHE B 1 278 ? -78.63653  -23.67590 -105.01973 1.000 43.73821 ? 278 PHE B O   1 
ATOM   4975 C CB  . PHE B 1 278 ? -77.80609  -21.31492 -102.77059 1.000 38.11374 ? 278 PHE B CB  1 
ATOM   4976 C CG  . PHE B 1 278 ? -78.24101  -20.82300 -101.41598 1.000 34.42821 ? 278 PHE B CG  1 
ATOM   4977 C CD1 . PHE B 1 278 ? -78.91973  -21.66030 -100.54214 1.000 36.98713 ? 278 PHE B CD1 1 
ATOM   4978 C CD2 . PHE B 1 278 ? -77.98745  -19.51367 -101.02503 1.000 31.40261 ? 278 PHE B CD2 1 
ATOM   4979 C CE1 . PHE B 1 278 ? -79.32630  -21.20754 -99.29894  1.000 34.01708 ? 278 PHE B CE1 1 
ATOM   4980 C CE2 . PHE B 1 278 ? -78.39544  -19.05397 -99.78938  1.000 32.81484 ? 278 PHE B CE2 1 
ATOM   4981 C CZ  . PHE B 1 278 ? -79.06169  -19.90276 -98.92072  1.000 29.94601 ? 278 PHE B CZ  1 
ATOM   4982 N N   . LYS B 1 279 ? -76.46521  -23.05432 -104.94295 1.000 39.88973 ? 279 LYS B N   1 
ATOM   4983 C CA  . LYS B 1 279 ? -76.19976  -23.43286 -106.33176 1.000 39.40326 ? 279 LYS B CA  1 
ATOM   4984 C C   . LYS B 1 279 ? -76.57429  -24.88351 -106.59492 1.000 38.85870 ? 279 LYS B C   1 
ATOM   4985 O O   . LYS B 1 279 ? -77.08335  -25.22402 -107.66796 1.000 45.48072 ? 279 LYS B O   1 
ATOM   4986 C CB  . LYS B 1 279 ? -74.72439  -23.20538 -106.66089 1.000 34.85873 ? 279 LYS B CB  1 
ATOM   4987 C CG  . LYS B 1 279 ? -74.36532  -23.32729 -108.13819 1.000 41.21091 ? 279 LYS B CG  1 
ATOM   4988 C CD  . LYS B 1 279 ? -72.87311  -23.12622 -108.33392 1.000 48.58850 ? 279 LYS B CD  1 
ATOM   4989 C CE  . LYS B 1 279 ? -72.52893  -22.83155 -109.77614 1.000 53.56448 ? 279 LYS B CE  1 
ATOM   4990 N NZ  . LYS B 1 279 ? -73.04237  -21.49732 -110.16613 1.000 48.68522 ? 279 LYS B NZ  1 
ATOM   4991 N N   . GLU B 1 280 ? -76.31828  -25.75319 -105.62435 1.000 38.94681 ? 280 GLU B N   1 
ATOM   4992 C CA  . GLU B 1 280 ? -76.69383  -27.15178 -105.76476 1.000 45.36128 ? 280 GLU B CA  1 
ATOM   4993 C C   . GLU B 1 280 ? -78.19848  -27.30035 -105.94768 1.000 47.64991 ? 280 GLU B C   1 
ATOM   4994 O O   . GLU B 1 280 ? -78.66127  -28.14070 -106.72815 1.000 47.63445 ? 280 GLU B O   1 
ATOM   4995 C CB  . GLU B 1 280 ? -76.21138  -27.93149 -104.54143 1.000 45.92039 ? 280 GLU B CB  1 
ATOM   4996 C CG  . GLU B 1 280 ? -76.40135  -29.42967 -104.64328 1.000 44.54148 ? 280 GLU B CG  1 
ATOM   4997 C CD  . GLU B 1 280 ? -75.96472  -30.14818 -103.38047 1.000 51.84487 ? 280 GLU B CD  1 
ATOM   4998 O OE1 . GLU B 1 280 ? -75.16151  -29.57630 -102.60361 1.000 45.41149 ? 280 GLU B OE1 1 
ATOM   4999 O OE2 . GLU B 1 280 ? -76.41796  -31.29239 -103.17100 1.000 57.23093 ? 280 GLU B OE2 1 
ATOM   5000 N N   . TYR B 1 281 ? -78.98160  -26.48142 -105.24880 1.000 48.65696 ? 281 TYR B N   1 
ATOM   5001 C CA  . TYR B 1 281 ? -80.43257  -26.52666 -105.35537 1.000 44.45866 ? 281 TYR B CA  1 
ATOM   5002 C C   . TYR B 1 281 ? -80.98614  -25.41970 -106.24729 1.000 45.95138 ? 281 TYR B C   1 
ATOM   5003 O O   . TYR B 1 281 ? -82.12165  -24.97061 -106.03748 1.000 40.58681 ? 281 TYR B O   1 
ATOM   5004 C CB  . TYR B 1 281 ? -81.05940  -26.46900 -103.96524 1.000 44.98652 ? 281 TYR B CB  1 
ATOM   5005 C CG  . TYR B 1 281 ? -80.82202  -27.73029 -103.17654 1.000 45.06891 ? 281 TYR B CG  1 
ATOM   5006 C CD1 . TYR B 1 281 ? -81.69217  -28.80941 -103.28742 1.000 44.94531 ? 281 TYR B CD1 1 
ATOM   5007 C CD2 . TYR B 1 281 ? -79.71424  -27.85929 -102.34090 1.000 45.28205 ? 281 TYR B CD2 1 
ATOM   5008 C CE1 . TYR B 1 281 ? -81.48502  -29.97810 -102.57144 1.000 44.20283 ? 281 TYR B CE1 1 
ATOM   5009 C CE2 . TYR B 1 281 ? -79.49186  -29.03275 -101.62404 1.000 46.39968 ? 281 TYR B CE2 1 
ATOM   5010 C CZ  . TYR B 1 281 ? -80.38633  -30.08475 -101.74565 1.000 50.87837 ? 281 TYR B CZ  1 
ATOM   5011 O OH  . TYR B 1 281 ? -80.19328  -31.25050 -101.04707 1.000 49.82833 ? 281 TYR B OH  1 
ATOM   5012 N N   . ARG B 1 282 ? -80.21456  -24.99581 -107.26124 1.000 42.01525 ? 282 ARG B N   1 
ATOM   5013 C CA  . ARG B 1 282 ? -80.66591  -23.96788 -108.19794 1.000 40.57116 ? 282 ARG B CA  1 
ATOM   5014 C C   . ARG B 1 282 ? -82.00001  -24.31491 -108.85918 1.000 42.48098 ? 282 ARG B C   1 
ATOM   5015 O O   . ARG B 1 282 ? -82.71217  -23.41019 -109.31373 1.000 41.89095 ? 282 ARG B O   1 
ATOM   5016 C CB  . ARG B 1 282 ? -79.59669  -23.73516 -109.27592 1.000 47.16131 ? 282 ARG B CB  1 
ATOM   5017 C CG  . ARG B 1 282 ? -79.16163  -25.00512 -110.00858 1.000 47.72192 ? 282 ARG B CG  1 
ATOM   5018 C CD  . ARG B 1 282 ? -77.96006  -24.78402 -110.93710 1.000 40.74868 ? 282 ARG B CD  1 
ATOM   5019 N NE  . ARG B 1 282 ? -78.29494  -24.05881 -112.16302 1.000 49.21133 ? 282 ARG B NE  1 
ATOM   5020 C CZ  . ARG B 1 282 ? -78.97116  -24.57494 -113.19524 1.000 60.68652 ? 282 ARG B CZ  1 
ATOM   5021 N NH1 . ARG B 1 282 ? -79.41518  -25.83061 -113.15509 1.000 42.93474 ? 282 ARG B NH1 1 
ATOM   5022 N NH2 . ARG B 1 282 ? -79.21999  -23.82999 -114.27323 1.000 46.29280 ? 282 ARG B NH2 1 
ATOM   5023 N N   . ASP B 1 283 ? -82.36261  -25.59917 -108.91686 1.000 43.00803 ? 283 ASP B N   1 
ATOM   5024 C CA  . ASP B 1 283 ? -83.62555  -25.98080 -109.54196 1.000 49.67914 ? 283 ASP B CA  1 
ATOM   5025 C C   . ASP B 1 283 ? -84.82567  -25.51349 -108.72623 1.000 47.35225 ? 283 ASP B C   1 
ATOM   5026 O O   . ASP B 1 283 ? -85.87040  -25.19437 -109.30353 1.000 42.52271 ? 283 ASP B O   1 
ATOM   5027 C CB  . ASP B 1 283 ? -83.68118  -27.50063 -109.75316 1.000 55.00500 ? 283 ASP B CB  1 
ATOM   5028 C CG  . ASP B 1 283 ? -82.70618  -27.98311 -110.82675 1.000 59.92543 ? 283 ASP B CG  1 
ATOM   5029 O OD1 . ASP B 1 283 ? -82.61370  -27.32774 -111.88411 1.000 59.84086 ? 283 ASP B OD1 1 
ATOM   5030 O OD2 . ASP B 1 283 ? -82.04099  -29.02055 -110.61950 1.000 74.05652 ? 283 ASP B OD2 1 
ATOM   5031 N N   . VAL B 1 284 ? -84.69801  -25.45280 -107.39839 1.000 49.02082 ? 284 VAL B N   1 
ATOM   5032 C CA  . VAL B 1 284 ? -85.80216  -25.04695 -106.53806 1.000 41.46776 ? 284 VAL B CA  1 
ATOM   5033 C C   . VAL B 1 284 ? -85.64936  -23.63538 -105.98134 1.000 41.95960 ? 284 VAL B C   1 
ATOM   5034 O O   . VAL B 1 284 ? -86.65904  -23.04184 -105.56709 1.000 47.62299 ? 284 VAL B O   1 
ATOM   5035 C CB  . VAL B 1 284 ? -86.01331  -26.04711 -105.38471 1.000 43.76890 ? 284 VAL B CB  1 
ATOM   5036 C CG1 . VAL B 1 284 ? -86.62197  -27.33108 -105.92485 1.000 53.76676 ? 284 VAL B CG1 1 
ATOM   5037 C CG2 . VAL B 1 284 ? -84.70731  -26.32844 -104.67206 1.000 44.97605 ? 284 VAL B CG2 1 
ATOM   5038 N N   . ILE B 1 285 ? -84.44314  -23.07920 -105.95265 1.000 38.17752 ? 285 ILE B N   1 
ATOM   5039 C CA  . ILE B 1 285 ? -84.21457  -21.72167 -105.46890 1.000 37.42073 ? 285 ILE B CA  1 
ATOM   5040 C C   . ILE B 1 285 ? -84.13967  -20.78926 -106.66553 1.000 37.26380 ? 285 ILE B C   1 
ATOM   5041 O O   . ILE B 1 285 ? -83.26755  -20.94331 -107.52886 1.000 43.08812 ? 285 ILE B O   1 
ATOM   5042 C CB  . ILE B 1 285 ? -82.93198  -21.62628 -104.63201 1.000 37.89392 ? 285 ILE B CB  1 
ATOM   5043 C CG1 . ILE B 1 285 ? -83.05437  -22.48264 -103.37186 1.000 32.99418 ? 285 ILE B CG1 1 
ATOM   5044 C CG2 . ILE B 1 285 ? -82.62857  -20.16289 -104.30501 1.000 27.68186 ? 285 ILE B CG2 1 
ATOM   5045 C CD1 . ILE B 1 285 ? -81.76986  -22.56805 -102.59324 1.000 30.95033 ? 285 ILE B CD1 1 
ATOM   5046 N N   A GLN B 1 286 ? -85.04584  -19.81281 -106.70577 0.479 34.68056 ? 286 GLN B N   1 
ATOM   5047 N N   B GLN B 1 286 ? -85.04146  -19.81251 -106.73227 0.521 34.66584 ? 286 GLN B N   1 
ATOM   5048 C CA  A GLN B 1 286 ? -85.12072  -18.86303 -107.80283 0.479 35.69852 ? 286 GLN B CA  1 
ATOM   5049 C CA  B GLN B 1 286 ? -85.02414  -18.87145 -107.84199 0.521 35.66908 ? 286 GLN B CA  1 
ATOM   5050 C C   A GLN B 1 286 ? -84.57686  -17.48403 -107.45012 0.479 34.37949 ? 286 GLN B C   1 
ATOM   5051 C C   B GLN B 1 286 ? -84.55806  -17.47261 -107.45594 0.521 34.30907 ? 286 GLN B C   1 
ATOM   5052 O O   A GLN B 1 286 ? -84.34884  -16.67858 -108.36002 0.479 36.01173 ? 286 GLN B O   1 
ATOM   5053 O O   B GLN B 1 286 ? -84.36873  -16.63863 -108.34898 0.521 35.95797 ? 286 GLN B O   1 
ATOM   5054 C CB  A GLN B 1 286 ? -86.57796  -18.72729 -108.28548 0.479 35.25391 ? 286 GLN B CB  1 
ATOM   5055 C CB  B GLN B 1 286 ? -86.41555  -18.78353 -108.49945 0.521 35.38894 ? 286 GLN B CB  1 
ATOM   5056 C CG  A GLN B 1 286 ? -87.11028  -19.92064 -109.08949 0.479 35.36470 ? 286 GLN B CG  1 
ATOM   5057 C CG  B GLN B 1 286 ? -86.86091  -20.04683 -109.26314 0.521 35.73577 ? 286 GLN B CG  1 
ATOM   5058 C CD  A GLN B 1 286 ? -87.27967  -21.18274 -108.25418 0.479 36.41518 ? 286 GLN B CD  1 
ATOM   5059 C CD  B GLN B 1 286 ? -85.77008  -20.66691 -110.15934 0.521 37.64075 ? 286 GLN B CD  1 
ATOM   5060 O OE1 A GLN B 1 286 ? -87.66791  -21.11813 -107.09385 0.479 37.78655 ? 286 GLN B OE1 1 
ATOM   5061 O OE1 B GLN B 1 286 ? -85.04205  -19.96691 -110.87215 0.521 34.34481 ? 286 GLN B OE1 1 
ATOM   5062 N NE2 A GLN B 1 286 ? -86.99495  -22.33605 -108.84823 0.479 37.91674 ? 286 GLN B NE2 1 
ATOM   5063 N NE2 B GLN B 1 286 ? -85.66581  -21.99390 -110.12282 0.521 39.93626 ? 286 GLN B NE2 1 
ATOM   5064 N N   . SER B 1 287 ? -84.35642  -17.19258 -106.16819 1.000 35.06304 ? 287 SER B N   1 
ATOM   5065 C CA  . SER B 1 287 ? -83.94612  -15.86172 -105.72914 1.000 30.90873 ? 287 SER B CA  1 
ATOM   5066 C C   . SER B 1 287 ? -83.26902  -15.93162 -104.37286 1.000 25.46447 ? 287 SER B C   1 
ATOM   5067 O O   . SER B 1 287 ? -83.73124  -16.64195 -103.47975 1.000 28.83085 ? 287 SER B O   1 
ATOM   5068 C CB  . SER B 1 287 ? -85.13343  -14.90379 -105.62807 1.000 30.97313 ? 287 SER B CB  1 
ATOM   5069 O OG  . SER B 1 287 ? -84.68154  -13.56738 -105.54632 1.000 31.10970 ? 287 SER B OG  1 
ATOM   5070 N N   . VAL B 1 288 ? -82.19895  -15.15623 -104.22679 1.000 27.21632 ? 288 VAL B N   1 
ATOM   5071 C CA  . VAL B 1 288 ? -81.44674  -15.01708 -102.98275 1.000 26.25679 ? 288 VAL B CA  1 
ATOM   5072 C C   . VAL B 1 288 ? -81.30390  -13.52319 -102.71938 1.000 25.06039 ? 288 VAL B C   1 
ATOM   5073 O O   . VAL B 1 288 ? -80.59422  -12.82443 -103.45220 1.000 21.17815 ? 288 VAL B O   1 
ATOM   5074 C CB  . VAL B 1 288 ? -80.06520  -15.69686 -103.04235 1.000 27.07004 ? 288 VAL B CB  1 
ATOM   5075 C CG1 . VAL B 1 288 ? -79.33845  -15.51432 -101.73181 1.000 29.18272 ? 288 VAL B CG1 1 
ATOM   5076 C CG2 . VAL B 1 288 ? -80.19586  -17.19586 -103.32252 1.000 24.04559 ? 288 VAL B CG2 1 
ATOM   5077 N N   . THR B 1 289 ? -81.97800  -13.03228 -101.68446 1.000 21.18887 ? 289 THR B N   1 
ATOM   5078 C CA  . THR B 1 289 ? -81.93591  -11.62741 -101.31035 1.000 21.26461 ? 289 THR B CA  1 
ATOM   5079 C C   . THR B 1 289 ? -81.24404  -11.47962 -99.96154  1.000 25.66067 ? 289 THR B C   1 
ATOM   5080 O O   . THR B 1 289 ? -81.64364  -12.12915 -98.99174  1.000 22.39974 ? 289 THR B O   1 
ATOM   5081 C CB  . THR B 1 289 ? -83.35071  -11.04016 -101.23640 1.000 21.81010 ? 289 THR B CB  1 
ATOM   5082 O OG1 . THR B 1 289 ? -83.98538  -11.14951 -102.51361 1.000 23.42308 ? 289 THR B OG1 1 
ATOM   5083 C CG2 . THR B 1 289 ? -83.29650  -9.57553  -100.82802 1.000 19.46263 ? 289 THR B CG2 1 
ATOM   5084 N N   . PHE B 1 290 ? -80.20526  -10.64090 -99.90485  1.000 24.53441 ? 290 PHE B N   1 
ATOM   5085 C CA  . PHE B 1 290 ? -79.61255  -10.24349 -98.63149  1.000 24.05544 ? 290 PHE B CA  1 
ATOM   5086 C C   . PHE B 1 290 ? -80.46906  -9.17473  -97.95949  1.000 25.14238 ? 290 PHE B C   1 
ATOM   5087 O O   . PHE B 1 290 ? -81.10436  -8.35541  -98.63441  1.000 24.78432 ? 290 PHE B O   1 
ATOM   5088 C CB  . PHE B 1 290 ? -78.20657  -9.66190  -98.82545  1.000 26.82311 ? 290 PHE B CB  1 
ATOM   5089 C CG  . PHE B 1 290 ? -77.21188  -10.61016 -99.42787  1.000 27.68662 ? 290 PHE B CG  1 
ATOM   5090 C CD1 . PHE B 1 290 ? -77.12013  -10.76116 -100.80622 1.000 30.03907 ? 290 PHE B CD1 1 
ATOM   5091 C CD2 . PHE B 1 290 ? -76.32214  -11.30905 -98.61749  1.000 26.24237 ? 290 PHE B CD2 1 
ATOM   5092 C CE1 . PHE B 1 290 ? -76.17906  -11.61644 -101.36922 1.000 27.39554 ? 290 PHE B CE1 1 
ATOM   5093 C CE2 . PHE B 1 290 ? -75.37086  -12.16232 -99.17417  1.000 23.56632 ? 290 PHE B CE2 1 
ATOM   5094 C CZ  . PHE B 1 290 ? -75.30828  -12.32023 -100.55202 1.000 28.77491 ? 290 PHE B CZ  1 
ATOM   5095 N N   . TRP B 1 291 ? -80.44923  -9.14906  -96.62060  1.000 24.36874 ? 291 TRP B N   1 
ATOM   5096 C CA  . TRP B 1 291 ? -81.13495  -8.07912  -95.88137  1.000 21.93592 ? 291 TRP B CA  1 
ATOM   5097 C C   . TRP B 1 291 ? -80.21545  -6.87056  -95.70211  1.000 15.43386 ? 291 TRP B C   1 
ATOM   5098 O O   . TRP B 1 291 ? -79.89734  -6.42935  -94.59377  1.000 26.83787 ? 291 TRP B O   1 
ATOM   5099 C CB  . TRP B 1 291 ? -81.66417  -8.58181  -94.54321  1.000 19.27187 ? 291 TRP B CB  1 
ATOM   5100 C CG  . TRP B 1 291 ? -82.96412  -7.89080  -94.11745  1.000 24.24668 ? 291 TRP B CG  1 
ATOM   5101 C CD1 . TRP B 1 291 ? -83.17354  -7.22566  -92.95709  1.000 25.54217 ? 291 TRP B CD1 1 
ATOM   5102 C CD2 . TRP B 1 291 ? -84.21577  -7.83280  -94.83801  1.000 25.21589 ? 291 TRP B CD2 1 
ATOM   5103 N NE1 . TRP B 1 291 ? -84.45516  -6.73161  -92.90555  1.000 19.69964 ? 291 TRP B NE1 1 
ATOM   5104 C CE2 . TRP B 1 291 ? -85.12114  -7.09804  -94.04151  1.000 19.53704 ? 291 TRP B CE2 1 
ATOM   5105 C CE3 . TRP B 1 291 ? -84.65470  -8.32433  -96.07425  1.000 25.93807 ? 291 TRP B CE3 1 
ATOM   5106 C CZ2 . TRP B 1 291 ? -86.43804  -6.82755  -94.44412  1.000 21.37523 ? 291 TRP B CZ2 1 
ATOM   5107 C CZ3 . TRP B 1 291 ? -85.97883  -8.06271  -96.47184  1.000 21.95652 ? 291 TRP B CZ3 1 
ATOM   5108 C CH2 . TRP B 1 291 ? -86.84558  -7.32257  -95.65780  1.000 20.98103 ? 291 TRP B CH2 1 
ATOM   5109 N N   . GLY B 1 292 ? -79.81953  -6.32433  -96.82540  1.000 16.70018 ? 292 GLY B N   1 
ATOM   5110 C CA  . GLY B 1 292 ? -78.82874  -5.27919  -96.91132  1.000 25.85663 ? 292 GLY B CA  1 
ATOM   5111 C C   . GLY B 1 292 ? -77.96405  -5.56263  -98.10564  1.000 24.42246 ? 292 GLY B C   1 
ATOM   5112 O O   . GLY B 1 292 ? -78.31218  -6.38341  -98.95085  1.000 26.10685 ? 292 GLY B O   1 
ATOM   5113 N N   . ILE B 1 293 ? -76.82249  -4.88049  -98.19517  1.000 23.36029 ? 293 ILE B N   1 
ATOM   5114 C CA  . ILE B 1 293 ? -75.83734  -5.28539  -99.19232  1.000 27.84842 ? 293 ILE B CA  1 
ATOM   5115 C C   . ILE B 1 293 ? -74.42839  -5.12727  -98.63034  1.000 27.70542 ? 293 ILE B C   1 
ATOM   5116 O O   . ILE B 1 293 ? -73.53652  -5.93018  -98.95158  1.000 23.50921 ? 293 ILE B O   1 
ATOM   5117 C CB  . ILE B 1 293 ? -76.01363  -4.52736  -100.52566 1.000 21.89670 ? 293 ILE B CB  1 
ATOM   5118 C CG1 . ILE B 1 293 ? -75.10794  -5.15096  -101.59557 1.000 21.99796 ? 293 ILE B CG1 1 
ATOM   5119 C CG2 . ILE B 1 293 ? -75.87107  -3.01722  -100.34635 1.000 18.96047 ? 293 ILE B CG2 1 
ATOM   5120 C CD1 . ILE B 1 293 ? -75.41170  -4.70091  -102.99921 1.000 29.74403 ? 293 ILE B CD1 1 
ATOM   5121 N N   . ALA B 1 294 ? -74.22599  -4.13976  -97.74756  1.000 23.20292 ? 294 ALA B N   1 
ATOM   5122 C CA  . ALA B 1 294 ? -72.90596  -3.89156  -97.18159  1.000 24.48270 ? 294 ALA B CA  1 
ATOM   5123 C C   . ALA B 1 294 ? -73.00649  -3.55385  -95.70283  1.000 24.57062 ? 294 ALA B C   1 
ATOM   5124 O O   . ALA B 1 294 ? -74.02905  -3.05938  -95.21662  1.000 22.44409 ? 294 ALA B O   1 
ATOM   5125 C CB  . ALA B 1 294 ? -72.18001  -2.75994  -97.90197  1.000 23.65974 ? 294 ALA B CB  1 
ATOM   5126 N N   . ASP B 1 295 ? -71.89792  -3.78650  -94.99400  1.000 25.20082 ? 295 ASP B N   1 
ATOM   5127 C CA  . ASP B 1 295 ? -71.88424  -3.67869  -93.54494  1.000 21.23764 ? 295 ASP B CA  1 
ATOM   5128 C C   . ASP B 1 295 ? -72.03335  -2.25310  -93.03459  1.000 22.94471 ? 295 ASP B C   1 
ATOM   5129 O O   . ASP B 1 295 ? -72.04535  -2.07716  -91.81289  1.000 22.97993 ? 295 ASP B O   1 
ATOM   5130 C CB  . ASP B 1 295 ? -70.60018  -4.30008  -92.99600  1.000 25.52867 ? 295 ASP B CB  1 
ATOM   5131 C CG  . ASP B 1 295 ? -70.59298  -5.81145  -93.10571  1.000 31.51614 ? 295 ASP B CG  1 
ATOM   5132 O OD1 . ASP B 1 295 ? -71.66011  -6.39971  -93.44174  1.000 28.24157 ? 295 ASP B OD1 1 
ATOM   5133 O OD2 . ASP B 1 295 ? -69.52625  -6.42239  -92.85155  1.000 26.35221 ? 295 ASP B OD2 1 
ATOM   5134 N N   . ASP B 1 296 ? -72.19388  -1.23581  -93.88894  1.000 23.83258 ? 296 ASP B N   1 
ATOM   5135 C CA  . ASP B 1 296 ? -72.48304  0.09414   -93.36399  1.000 25.36410 ? 296 ASP B CA  1 
ATOM   5136 C C   . ASP B 1 296 ? -73.96170  0.29570   -93.00996  1.000 28.56356 ? 296 ASP B C   1 
ATOM   5137 O O   . ASP B 1 296 ? -74.29633  1.28829   -92.33961  1.000 27.13227 ? 296 ASP B O   1 
ATOM   5138 C CB  . ASP B 1 296 ? -72.01633  1.17761   -94.34334  1.000 28.13873 ? 296 ASP B CB  1 
ATOM   5139 C CG  . ASP B 1 296 ? -72.50794  0.96283   -95.75204  1.000 25.48193 ? 296 ASP B CG  1 
ATOM   5140 O OD1 . ASP B 1 296 ? -72.85082  -0.18776  -96.10461  1.000 26.80081 ? 296 ASP B OD1 1 
ATOM   5141 O OD2 . ASP B 1 296 ? -72.44937  1.90916   -96.54928  1.000 26.40021 ? 296 ASP B OD2 1 
ATOM   5142 N N   A HIS B 1 297 ? -74.87195  -0.59997  -93.47818  0.663 22.79988 ? 297 HIS B N   1 
ATOM   5143 N N   B HIS B 1 297 ? -74.86864  -0.56811  -93.44616  0.337 24.06367 ? 297 HIS B N   1 
ATOM   5144 C CA  A HIS B 1 297 ? -76.27086  -0.63132  -93.04917  0.663 24.09863 ? 297 HIS B CA  1 
ATOM   5145 C CA  B HIS B 1 297 ? -76.22661  -0.53959  -92.91897  0.337 24.18510 ? 297 HIS B CA  1 
ATOM   5146 C C   A HIS B 1 297 ? -76.70107  -2.07591  -92.80014  0.663 24.74956 ? 297 HIS B C   1 
ATOM   5147 C C   B HIS B 1 297 ? -76.73687  -1.96542  -92.79858  0.337 24.74936 ? 297 HIS B C   1 
ATOM   5148 O O   A HIS B 1 297 ? -76.74382  -2.91091  -93.71886  0.663 24.14718 ? 297 HIS B O   1 
ATOM   5149 O O   B HIS B 1 297 ? -76.87557  -2.66420  -93.81711  0.337 24.27173 ? 297 HIS B O   1 
ATOM   5150 C CB  A HIS B 1 297 ? -77.18454  -0.03694  -94.09807  0.663 23.10041 ? 297 HIS B CB  1 
ATOM   5151 C CB  B HIS B 1 297 ? -77.18995  0.31841   -93.77325  0.337 24.50239 ? 297 HIS B CB  1 
ATOM   5152 C CG  A HIS B 1 297 ? -78.62991  -0.13954  -93.71848  0.663 22.59393 ? 297 HIS B CG  1 
ATOM   5153 C CG  B HIS B 1 297 ? -77.31959  1.76539   -93.32474  0.337 35.37559 ? 297 HIS B CG  1 
ATOM   5154 N ND1 A HIS B 1 297 ? -79.27247  0.82153   -92.97555  0.663 18.79652 ? 297 HIS B ND1 1 
ATOM   5155 N ND1 B HIS B 1 297 ? -78.51074  2.46864   -93.37196  0.337 34.36897 ? 297 HIS B ND1 1 
ATOM   5156 C CD2 A HIS B 1 297 ? -79.53304  -1.12922  -93.90003  0.663 16.52196 ? 297 HIS B CD2 1 
ATOM   5157 C CD2 B HIS B 1 297 ? -76.39583  2.65239   -92.87256  0.337 36.47461 ? 297 HIS B CD2 1 
ATOM   5158 C CE1 A HIS B 1 297 ? -80.51706  0.45328   -92.75150  0.663 17.48709 ? 297 HIS B CE1 1 
ATOM   5159 C CE1 B HIS B 1 297 ? -78.31474  3.70807   -92.95042  0.337 32.68283 ? 297 HIS B CE1 1 
ATOM   5160 N NE2 A HIS B 1 297 ? -80.69987  -0.73135  -93.29799  0.663 19.34652 ? 297 HIS B NE2 1 
ATOM   5161 N NE2 B HIS B 1 297 ? -77.04208  3.84134   -92.62308  0.337 31.61676 ? 297 HIS B NE2 1 
ATOM   5162 N N   . THR B 1 298 ? -77.06243  -2.36845  -91.56028  1.000 22.45426 ? 298 THR B N   1 
ATOM   5163 C CA  . THR B 1 298 ? -77.60783  -3.69210  -91.27533  1.000 21.85084 ? 298 THR B CA  1 
ATOM   5164 C C   . THR B 1 298 ? -78.44333  -3.61470  -90.00874  1.000 26.96140 ? 298 THR B C   1 
ATOM   5165 O O   . THR B 1 298 ? -78.03427  -2.99479  -89.01760  1.000 29.80019 ? 298 THR B O   1 
ATOM   5166 C CB  . THR B 1 298 ? -76.49241  -4.73617  -91.12368  1.000 25.53657 ? 298 THR B CB  1 
ATOM   5167 O OG1 . THR B 1 298 ? -77.04439  -5.97355  -90.62504  1.000 20.06145 ? 298 THR B OG1 1 
ATOM   5168 C CG2 . THR B 1 298 ? -75.40602  -4.24181  -90.16294  1.000 21.55575 ? 298 THR B CG2 1 
ATOM   5169 N N   . TRP B 1 299 ? -79.62732  -4.23277  -90.04976  1.000 25.09669 ? 299 TRP B N   1 
ATOM   5170 C CA  . TRP B 1 299 ? -80.50476  -4.25354  -88.88285  1.000 24.35215 ? 299 TRP B CA  1 
ATOM   5171 C C   . TRP B 1 299 ? -79.87145  -4.98115  -87.70282  1.000 26.42648 ? 299 TRP B C   1 
ATOM   5172 O O   . TRP B 1 299 ? -80.32970  -4.81106  -86.56453  1.000 23.95856 ? 299 TRP B O   1 
ATOM   5173 C CB  . TRP B 1 299 ? -81.85364  -4.90747  -89.22081  1.000 22.88706 ? 299 TRP B CB  1 
ATOM   5174 C CG  . TRP B 1 299 ? -81.77768  -6.40209  -89.37109  1.000 22.32172 ? 299 TRP B CG  1 
ATOM   5175 C CD1 . TRP B 1 299 ? -81.05276  -7.09017  -90.29914  1.000 20.80634 ? 299 TRP B CD1 1 
ATOM   5176 C CD2 . TRP B 1 299 ? -82.42894  -7.38992  -88.56110  1.000 23.53112 ? 299 TRP B CD2 1 
ATOM   5177 N NE1 . TRP B 1 299 ? -81.21080  -8.43977  -90.11993  1.000 22.16077 ? 299 TRP B NE1 1 
ATOM   5178 C CE2 . TRP B 1 299 ? -82.05054  -8.65291  -89.06075  1.000 19.65054 ? 299 TRP B CE2 1 
ATOM   5179 C CE3 . TRP B 1 299 ? -83.27781  -7.33174  -87.45360  1.000 30.64181 ? 299 TRP B CE3 1 
ATOM   5180 C CZ2 . TRP B 1 299 ? -82.49951  -9.84660  -88.49815  1.000 29.17597 ? 299 TRP B CZ2 1 
ATOM   5181 C CZ3 . TRP B 1 299 ? -83.73050  -8.52078  -86.89949  1.000 31.17579 ? 299 TRP B CZ3 1 
ATOM   5182 C CH2 . TRP B 1 299 ? -83.33592  -9.75919  -87.41826  1.000 33.06510 ? 299 TRP B CH2 1 
ATOM   5183 N N   . LEU B 1 300 ? -78.83368  -5.78598  -87.94124  1.000 21.69721 ? 300 LEU B N   1 
ATOM   5184 C CA  . LEU B 1 300 ? -78.18321  -6.50506  -86.85045  1.000 25.53507 ? 300 LEU B CA  1 
ATOM   5185 C C   . LEU B 1 300 ? -77.30514  -5.59460  -86.00949  1.000 24.71784 ? 300 LEU B C   1 
ATOM   5186 O O   . LEU B 1 300 ? -76.76112  -6.04230  -84.99653  1.000 27.47303 ? 300 LEU B O   1 
ATOM   5187 C CB  . LEU B 1 300 ? -77.36256  -7.66245  -87.40676  1.000 21.02020 ? 300 LEU B CB  1 
ATOM   5188 C CG  . LEU B 1 300 ? -78.14519  -8.82132  -88.01668  1.000 23.11049 ? 300 LEU B CG  1 
ATOM   5189 C CD1 . LEU B 1 300 ? -77.21717  -9.82025  -88.71145  1.000 25.33355 ? 300 LEU B CD1 1 
ATOM   5190 C CD2 . LEU B 1 300 ? -78.97777  -9.52312  -86.93917  1.000 28.21763 ? 300 LEU B CD2 1 
ATOM   5191 N N   . ASP B 1 301 ? -77.15714  -4.33699  -86.41580  1.000 22.82049 ? 301 ASP B N   1 
ATOM   5192 C CA  . ASP B 1 301 ? -76.43799  -3.35862  -85.62646  1.000 24.76218 ? 301 ASP B CA  1 
ATOM   5193 C C   . ASP B 1 301 ? -77.20260  -2.96308  -84.38614  1.000 37.05294 ? 301 ASP B C   1 
ATOM   5194 O O   . ASP B 1 301 ? -76.61350  -2.37020  -83.47239  1.000 34.29206 ? 301 ASP B O   1 
ATOM   5195 C CB  . ASP B 1 301 ? -76.16505  -2.10448  -86.44743  1.000 27.34554 ? 301 ASP B CB  1 
ATOM   5196 C CG  . ASP B 1 301 ? -74.95812  -2.24975  -87.32552  1.000 31.23452 ? 301 ASP B CG  1 
ATOM   5197 O OD1 . ASP B 1 301 ? -74.28816  -3.29705  -87.18363  1.000 30.65933 ? 301 ASP B OD1 1 
ATOM   5198 O OD2 . ASP B 1 301 ? -74.68627  -1.32463  -88.13734  1.000 27.13288 ? 301 ASP B OD2 1 
ATOM   5199 N N   . ASN B 1 302 ? -78.50211  -3.26203  -84.34693  1.000 33.31984 ? 302 ASN B N   1 
ATOM   5200 C CA  . ASN B 1 302 ? -79.35117  -2.86239  -83.24580  1.000 26.33177 ? 302 ASN B CA  1 
ATOM   5201 C C   . ASN B 1 302 ? -80.20611  -3.99555  -82.72642  1.000 30.52969 ? 302 ASN B C   1 
ATOM   5202 O O   . ASN B 1 302 ? -80.94521  -3.79891  -81.75749  1.000 34.05461 ? 302 ASN B O   1 
ATOM   5203 C CB  . ASN B 1 302 ? -80.22637  -1.68858  -83.66879  1.000 28.43102 ? 302 ASN B CB  1 
ATOM   5204 C CG  . ASN B 1 302 ? -79.42929  -0.42781  -83.77976  1.000 35.84237 ? 302 ASN B CG  1 
ATOM   5205 O OD1 . ASN B 1 302 ? -78.75025  -0.03635  -82.82776  1.000 37.59905 ? 302 ASN B OD1 1 
ATOM   5206 N ND2 . ASN B 1 302 ? -79.46382  0.20166   -84.94583  1.000 34.56415 ? 302 ASN B ND2 1 
ATOM   5207 N N   . PHE B 1 303 ? -80.11411  -5.17190  -83.33074  1.000 26.49777 ? 303 PHE B N   1 
ATOM   5208 C CA  . PHE B 1 303 ? -80.78957  -6.36097  -82.86399  1.000 29.42652 ? 303 PHE B CA  1 
ATOM   5209 C C   . PHE B 1 303 ? -79.81159  -7.52577  -82.89110  1.000 23.92687 ? 303 PHE B C   1 
ATOM   5210 O O   . PHE B 1 303 ? -79.06811  -7.68418  -83.85832  1.000 28.50262 ? 303 PHE B O   1 
ATOM   5211 C CB  . PHE B 1 303 ? -82.02472  -6.69787  -83.72906  1.000 31.36089 ? 303 PHE B CB  1 
ATOM   5212 C CG  . PHE B 1 303 ? -82.67492  -7.99109  -83.34043  1.000 32.97196 ? 303 PHE B CG  1 
ATOM   5213 C CD1 . PHE B 1 303 ? -83.60845  -8.02230  -82.32634  1.000 32.82582 ? 303 PHE B CD1 1 
ATOM   5214 C CD2 . PHE B 1 303 ? -82.31732  -9.18479  -83.94948  1.000 30.98226 ? 303 PHE B CD2 1 
ATOM   5215 C CE1 . PHE B 1 303 ? -84.18503  -9.21279  -81.93910  1.000 38.32652 ? 303 PHE B CE1 1 
ATOM   5216 C CE2 . PHE B 1 303 ? -82.89376  -10.37520 -83.56772  1.000 35.76152 ? 303 PHE B CE2 1 
ATOM   5217 C CZ  . PHE B 1 303 ? -83.82672  -10.39130 -82.56151  1.000 36.41617 ? 303 PHE B CZ  1 
ATOM   5218 N N   . PRO B 1 304 ? -79.78807  -8.36033  -81.85096  1.000 33.09963 ? 304 PRO B N   1 
ATOM   5219 C CA  . PRO B 1 304 ? -80.55461  -8.23245  -80.60835  1.000 35.45816 ? 304 PRO B CA  1 
ATOM   5220 C C   . PRO B 1 304 ? -79.94514  -7.30188  -79.56065  1.000 31.98591 ? 304 PRO B C   1 
ATOM   5221 O O   . PRO B 1 304 ? -80.49927  -7.23996  -78.46958  1.000 38.12208 ? 304 PRO B O   1 
ATOM   5222 C CB  . PRO B 1 304 ? -80.57903  -9.65970  -80.07174  1.000 33.81970 ? 304 PRO B CB  1 
ATOM   5223 C CG  . PRO B 1 304 ? -79.34567  -10.27080 -80.60731  1.000 30.15696 ? 304 PRO B CG  1 
ATOM   5224 C CD  . PRO B 1 304 ? -79.15206  -9.68006  -81.96627  1.000 28.87726 ? 304 PRO B CD  1 
ATOM   5225 N N   . VAL B 1 305 ? -78.86254  -6.58864  -79.86188  1.000 26.34803 ? 305 VAL B N   1 
ATOM   5226 C CA  . VAL B 1 305 ? -78.29037  -5.61443  -78.92969  1.000 26.48479 ? 305 VAL B CA  1 
ATOM   5227 C C   . VAL B 1 305 ? -78.25070  -4.25085  -79.60054  1.000 30.14356 ? 305 VAL B C   1 
ATOM   5228 O O   . VAL B 1 305 ? -77.59533  -4.07681  -80.63745  1.000 35.97802 ? 305 VAL B O   1 
ATOM   5229 C CB  . VAL B 1 305 ? -76.89563  -6.02719  -78.43802  1.000 28.87163 ? 305 VAL B CB  1 
ATOM   5230 C CG1 . VAL B 1 305 ? -76.37591  -5.00679  -77.42420  1.000 28.12445 ? 305 VAL B CG1 1 
ATOM   5231 C CG2 . VAL B 1 305 ? -76.96060  -7.41630  -77.81199  1.000 27.92644 ? 305 VAL B CG2 1 
ATOM   5232 N N   . HIS B 1 306 ? -78.95631  -3.29178  -79.01009  1.000 28.62203 ? 306 HIS B N   1 
ATOM   5233 C CA  . HIS B 1 306 ? -79.00967  -1.93769  -79.54129  1.000 32.94334 ? 306 HIS B CA  1 
ATOM   5234 C C   . HIS B 1 306 ? -77.62350  -1.31653  -79.47019  1.000 33.95924 ? 306 HIS B C   1 
ATOM   5235 O O   . HIS B 1 306 ? -76.92482  -1.45510  -78.46257  1.000 36.89849 ? 306 HIS B O   1 
ATOM   5236 C CB  . HIS B 1 306 ? -80.02770  -1.11239  -78.74689  1.000 30.18373 ? 306 HIS B CB  1 
ATOM   5237 C CG  . HIS B 1 306 ? -80.30679  0.24764   -79.31241  1.000 34.90941 ? 306 HIS B CG  1 
ATOM   5238 N ND1 . HIS B 1 306 ? -79.71607  1.39458   -78.82263  1.000 31.16530 ? 306 HIS B ND1 1 
ATOM   5239 C CD2 . HIS B 1 306 ? -81.13582  0.64667   -80.30858  1.000 29.69863 ? 306 HIS B CD2 1 
ATOM   5240 C CE1 . HIS B 1 306 ? -80.16168  2.43992   -79.49768  1.000 34.48245 ? 306 HIS B CE1 1 
ATOM   5241 N NE2 . HIS B 1 306 ? -81.01989  2.01250   -80.40816  1.000 41.70479 ? 306 HIS B NE2 1 
ATOM   5242 N N   . GLY B 1 307 ? -77.20513  -0.68463  -80.56409  1.000 38.39235 ? 307 GLY B N   1 
ATOM   5243 C CA  . GLY B 1 307 ? -75.93346  0.00644   -80.62232  1.000 33.65924 ? 307 GLY B CA  1 
ATOM   5244 C C   . GLY B 1 307 ? -74.69558  -0.86087  -80.69734  1.000 36.22385 ? 307 GLY B C   1 
ATOM   5245 O O   . GLY B 1 307 ? -73.59087  -0.33524  -80.52924  1.000 40.26185 ? 307 GLY B O   1 
ATOM   5246 N N   . ARG B 1 308 ? -74.82782  -2.16050  -80.94199  1.000 33.55841 ? 308 ARG B N   1 
ATOM   5247 C CA  . ARG B 1 308 ? -73.67881  -3.05022  -81.07959  1.000 29.39450 ? 308 ARG B CA  1 
ATOM   5248 C C   . ARG B 1 308 ? -73.45070  -3.36357  -82.55099  1.000 33.46493 ? 308 ARG B C   1 
ATOM   5249 O O   . ARG B 1 308 ? -74.30710  -3.97736  -83.19586  1.000 38.76375 ? 308 ARG B O   1 
ATOM   5250 C CB  . ARG B 1 308 ? -73.87955  -4.36018  -80.32679  1.000 31.02833 ? 308 ARG B CB  1 
ATOM   5251 C CG  . ARG B 1 308 ? -72.92200  -5.41098  -80.85099  1.000 34.91501 ? 308 ARG B CG  1 
ATOM   5252 C CD  . ARG B 1 308 ? -73.20315  -6.77188  -80.31597  1.000 27.39749 ? 308 ARG B CD  1 
ATOM   5253 N NE  . ARG B 1 308 ? -74.28007  -7.45373  -81.00911  1.000 25.57887 ? 308 ARG B NE  1 
ATOM   5254 C CZ  . ARG B 1 308 ? -74.65422  -8.68415  -80.68855  1.000 32.08482 ? 308 ARG B CZ  1 
ATOM   5255 N NH1 . ARG B 1 308 ? -74.00787  -9.30783  -79.70850  1.000 27.03851 ? 308 ARG B NH1 1 
ATOM   5256 N NH2 . ARG B 1 308 ? -75.66353  -9.28196  -81.31695  1.000 25.45132 ? 308 ARG B NH2 1 
ATOM   5257 N N   A LYS B 1 309 ? -72.28244  -2.99044  -83.06199  1.000 30.13370 ? 309 LYS B N   1 
ATOM   5258 N N   B LYS B 1 309 ? -72.30041  -2.95461  -83.07557  0.000 30.26320 ? 309 LYS B N   1 
ATOM   5259 C CA  A LYS B 1 309 ? -72.01185  -3.15654  -84.47999  1.000 29.23193 ? 309 LYS B CA  1 
ATOM   5260 C CA  B LYS B 1 309 ? -72.02243  -3.13040  -84.49450  0.000 28.88233 ? 309 LYS B CA  1 
ATOM   5261 C C   A LYS B 1 309 ? -71.84619  -4.62784  -84.83261  1.000 29.44029 ? 309 LYS B C   1 
ATOM   5262 C C   B LYS B 1 309 ? -71.83395  -4.60524  -84.84230  0.000 29.32716 ? 309 LYS B C   1 
ATOM   5263 O O   A LYS B 1 309 ? -71.31122  -5.42077  -84.05057  1.000 29.28731 ? 309 LYS B O   1 
ATOM   5264 O O   B LYS B 1 309 ? -71.26979  -5.37977  -84.06339  0.000 29.61332 ? 309 LYS B O   1 
ATOM   5265 C CB  A LYS B 1 309 ? -70.76446  -2.37840  -84.88781  1.000 25.62756 ? 309 LYS B CB  1 
ATOM   5266 C CB  B LYS B 1 309 ? -70.77959  -2.33010  -84.88632  0.000 27.03823 ? 309 LYS B CB  1 
ATOM   5267 C CG  A LYS B 1 309 ? -70.56167  -2.29735  -86.40926  1.000 25.98616 ? 309 LYS B CG  1 
ATOM   5268 C CG  B LYS B 1 309 ? -70.55988  -2.20108  -86.38366  0.000 26.84598 ? 309 LYS B CG  1 
ATOM   5269 C CD  A LYS B 1 309 ? -71.18416  -1.04947  -87.00258  1.000 24.47851 ? 309 LYS B CD  1 
ATOM   5270 C CD  B LYS B 1 309 ? -71.69352  -1.44010  -87.03781  0.000 26.57459 ? 309 LYS B CD  1 
ATOM   5271 C CE  A LYS B 1 309 ? -71.25648  -1.12891  -88.53111  1.000 24.70710 ? 309 LYS B CE  1 
ATOM   5272 C CE  B LYS B 1 309 ? -71.59780  -1.49952  -88.55020  0.000 26.24021 ? 309 LYS B CE  1 
ATOM   5273 N NZ  A LYS B 1 309 ? -72.01351  -2.33948  -88.97704  1.000 25.06954 ? 309 LYS B NZ  1 
ATOM   5274 N NZ  B LYS B 1 309 ? -70.84807  -0.34082  -89.08809  0.000 27.25045 ? 309 LYS B NZ  1 
ATOM   5275 N N   . ASN B 1 310 ? -72.31884  -4.98729  -86.02492  1.000 31.64027 ? 310 ASN B N   1 
ATOM   5276 C CA  . ASN B 1 310 ? -72.19060  -6.33044  -86.56976  1.000 24.55651 ? 310 ASN B CA  1 
ATOM   5277 C C   . ASN B 1 310 ? -71.65692  -6.20724  -87.99579  1.000 20.86021 ? 310 ASN B C   1 
ATOM   5278 O O   . ASN B 1 310 ? -71.60772  -5.11271  -88.56751  1.000 25.86735 ? 310 ASN B O   1 
ATOM   5279 C CB  . ASN B 1 310 ? -73.53867  -7.06378  -86.52169  1.000 25.62011 ? 310 ASN B CB  1 
ATOM   5280 C CG  . ASN B 1 310 ? -73.39593  -8.57262  -86.50585  1.000 28.01958 ? 310 ASN B CG  1 
ATOM   5281 O OD1 . ASN B 1 310 ? -72.48049  -9.14692  -87.11716  1.000 27.91639 ? 310 ASN B OD1 1 
ATOM   5282 N ND2 . ASN B 1 310 ? -74.32422  -9.23116  -85.82690  1.000 23.26638 ? 310 ASN B ND2 1 
ATOM   5283 N N   . TRP B 1 311 ? -71.21624  -7.32338  -88.57765  1.000 21.07315 ? 311 TRP B N   1 
ATOM   5284 C CA  . TRP B 1 311 ? -70.56719  -7.30870  -89.90001  1.000 28.78096 ? 311 TRP B CA  1 
ATOM   5285 C C   . TRP B 1 311 ? -71.06072  -8.48989  -90.71794  1.000 23.64261 ? 311 TRP B C   1 
ATOM   5286 O O   . TRP B 1 311 ? -70.29461  -9.39440  -91.07000  1.000 24.83059 ? 311 TRP B O   1 
ATOM   5287 C CB  . TRP B 1 311 ? -69.03725  -7.31926  -89.76474  1.000 26.69735 ? 311 TRP B CB  1 
ATOM   5288 C CG  . TRP B 1 311 ? -68.56315  -6.24533  -88.83126  1.000 21.43327 ? 311 TRP B CG  1 
ATOM   5289 C CD1 . TRP B 1 311 ? -68.25516  -4.95398  -89.15406  1.000 23.86835 ? 311 TRP B CD1 1 
ATOM   5290 C CD2 . TRP B 1 311 ? -68.41966  -6.34685  -87.41152  1.000 22.19882 ? 311 TRP B CD2 1 
ATOM   5291 N NE1 . TRP B 1 311 ? -67.91569  -4.25002  -88.02623  1.000 23.08749 ? 311 TRP B NE1 1 
ATOM   5292 C CE2 . TRP B 1 311 ? -68.00571  -5.08253  -86.94203  1.000 27.40690 ? 311 TRP B CE2 1 
ATOM   5293 C CE3 . TRP B 1 311 ? -68.57686  -7.39218  -86.49114  1.000 23.33405 ? 311 TRP B CE3 1 
ATOM   5294 C CZ2 . TRP B 1 311 ? -67.72738  -4.83798  -85.59400  1.000 29.29250 ? 311 TRP B CZ2 1 
ATOM   5295 C CZ3 . TRP B 1 311 ? -68.30121  -7.14328  -85.15066  1.000 25.64832 ? 311 TRP B CZ3 1 
ATOM   5296 C CH2 . TRP B 1 311 ? -67.88405  -5.87652  -84.71772  1.000 24.25691 ? 311 TRP B CH2 1 
ATOM   5297 N N   . PRO B 1 312 ? -72.34449  -8.49705  -91.07046  1.000 22.75055 ? 312 PRO B N   1 
ATOM   5298 C CA  . PRO B 1 312 ? -72.98524  -9.73425  -91.54624  1.000 18.75904 ? 312 PRO B CA  1 
ATOM   5299 C C   . PRO B 1 312 ? -73.06410  -9.95208  -93.04959  1.000 22.21838 ? 312 PRO B C   1 
ATOM   5300 O O   . PRO B 1 312 ? -73.60129  -10.99720 -93.45026  1.000 21.58527 ? 312 PRO B O   1 
ATOM   5301 C CB  . PRO B 1 312 ? -74.39463  -9.60211  -90.96653  1.000 25.88338 ? 312 PRO B CB  1 
ATOM   5302 C CG  . PRO B 1 312 ? -74.60786  -8.14529  -90.78344  1.000 23.69161 ? 312 PRO B CG  1 
ATOM   5303 C CD  . PRO B 1 312 ? -73.31523  -7.42852  -90.79353  1.000 16.11010 ? 312 PRO B CD  1 
ATOM   5304 N N   . LEU B 1 313 ? -72.53356  -9.04908  -93.87458  1.000 20.97481 ? 313 LEU B N   1 
ATOM   5305 C CA  . LEU B 1 313 ? -72.77341  -9.07750  -95.32085  1.000 26.57116 ? 313 LEU B CA  1 
ATOM   5306 C C   . LEU B 1 313 ? -71.47437  -9.33326  -96.09894  1.000 25.34777 ? 313 LEU B C   1 
ATOM   5307 O O   . LEU B 1 313 ? -70.40109  -9.52226  -95.52063  1.000 27.47877 ? 313 LEU B O   1 
ATOM   5308 C CB  . LEU B 1 313 ? -73.44209  -7.77379  -95.75551  1.000 21.31174 ? 313 LEU B CB  1 
ATOM   5309 C CG  . LEU B 1 313 ? -74.81011  -7.64475  -95.07107  1.000 21.89898 ? 313 LEU B CG  1 
ATOM   5310 C CD1 . LEU B 1 313 ? -75.32023  -6.20574  -95.09981  1.000 19.44938 ? 313 LEU B CD1 1 
ATOM   5311 C CD2 . LEU B 1 313 ? -75.79154  -8.59312  -95.74239  1.000 19.87533 ? 313 LEU B CD2 1 
ATOM   5312 N N   . LEU B 1 314 ? -71.58755  -9.34209  -97.43570  1.000 26.72382 ? 314 LEU B N   1 
ATOM   5313 C CA  . LEU B 1 314 ? -70.45451  -9.61755  -98.32126  1.000 25.02668 ? 314 LEU B CA  1 
ATOM   5314 C C   . LEU B 1 314 ? -69.53545  -8.42183  -98.53501  1.000 25.77941 ? 314 LEU B C   1 
ATOM   5315 O O   . LEU B 1 314 ? -68.39197  -8.61364  -98.95912  1.000 31.98604 ? 314 LEU B O   1 
ATOM   5316 C CB  . LEU B 1 314 ? -70.93663  -10.07496 -99.69258  1.000 22.52478 ? 314 LEU B CB  1 
ATOM   5317 C CG  . LEU B 1 314 ? -71.73447  -11.36469 -99.74196  1.000 24.27029 ? 314 LEU B CG  1 
ATOM   5318 C CD1 . LEU B 1 314 ? -71.94663  -11.77338 -101.18182 1.000 15.60551 ? 314 LEU B CD1 1 
ATOM   5319 C CD2 . LEU B 1 314 ? -71.01058  -12.44003 -98.96423  1.000 20.62292 ? 314 LEU B CD2 1 
ATOM   5320 N N   . PHE B 1 315 ? -69.99738  -7.20062  -98.29596  1.000 24.59503 ? 315 PHE B N   1 
ATOM   5321 C CA  . PHE B 1 315 ? -69.17750  -6.01455  -98.50427  1.000 23.45155 ? 315 PHE B CA  1 
ATOM   5322 C C   . PHE B 1 315 ? -68.99312  -5.27953  -97.18068  1.000 26.70224 ? 315 PHE B C   1 
ATOM   5323 O O   . PHE B 1 315 ? -69.89752  -5.24994  -96.33964  1.000 31.55362 ? 315 PHE B O   1 
ATOM   5324 C CB  . PHE B 1 315 ? -69.81511  -5.08485  -99.54103  1.000 23.39987 ? 315 PHE B CB  1 
ATOM   5325 C CG  . PHE B 1 315 ? -70.01489  -5.71612  -100.90236 1.000 24.49757 ? 315 PHE B CG  1 
ATOM   5326 C CD1 . PHE B 1 315 ? -68.96932  -5.73448  -101.83557 1.000 26.52409 ? 315 PHE B CD1 1 
ATOM   5327 C CD2 . PHE B 1 315 ? -71.24472  -6.25911  -101.27087 1.000 22.23631 ? 315 PHE B CD2 1 
ATOM   5328 C CE1 . PHE B 1 315 ? -69.14624  -6.29440  -103.10630 1.000 28.71560 ? 315 PHE B CE1 1 
ATOM   5329 C CE2 . PHE B 1 315 ? -71.43124  -6.83278  -102.55557 1.000 26.26793 ? 315 PHE B CE2 1 
ATOM   5330 C CZ  . PHE B 1 315 ? -70.37513  -6.83849  -103.46653 1.000 27.82232 ? 315 PHE B CZ  1 
ATOM   5331 N N   . ASP B 1 316 ? -67.81608  -4.69420  -96.98582  1.000 33.52701 ? 316 ASP B N   1 
ATOM   5332 C CA  . ASP B 1 316 ? -67.54276  -4.03841  -95.71709  1.000 31.07394 ? 316 ASP B CA  1 
ATOM   5333 C C   . ASP B 1 316 ? -68.12009  -2.62255  -95.73056  1.000 27.54901 ? 316 ASP B C   1 
ATOM   5334 O O   . ASP B 1 316 ? -68.74501  -2.18876  -96.70308  1.000 34.67242 ? 316 ASP B O   1 
ATOM   5335 C CB  . ASP B 1 316 ? -66.04068  -4.08204  -95.38783  1.000 33.95475 ? 316 ASP B CB  1 
ATOM   5336 C CG  . ASP B 1 316 ? -65.16031  -3.31036  -96.37775  1.000 35.74359 ? 316 ASP B CG  1 
ATOM   5337 O OD1 . ASP B 1 316 ? -65.65167  -2.37312  -97.03548  1.000 36.83802 ? 316 ASP B OD1 1 
ATOM   5338 O OD2 . ASP B 1 316 ? -63.94394  -3.62199  -96.46671  1.000 36.01127 ? 316 ASP B OD2 1 
ATOM   5339 N N   . GLU B 1 317 ? -67.92070  -1.89999  -94.62092  1.000 29.66893 ? 317 GLU B N   1 
ATOM   5340 C CA  . GLU B 1 317 ? -68.44613  -0.54882  -94.43094  1.000 26.86029 ? 317 GLU B CA  1 
ATOM   5341 C C   . GLU B 1 317 ? -67.90909  0.45193   -95.44052  1.000 33.31311 ? 317 GLU B C   1 
ATOM   5342 O O   . GLU B 1 317 ? -68.44459  1.56429   -95.52658  1.000 33.34028 ? 317 GLU B O   1 
ATOM   5343 C CB  . GLU B 1 317 ? -68.10997  -0.03876  -93.03193  1.000 23.97402 ? 317 GLU B CB  1 
ATOM   5344 C CG  . GLU B 1 317 ? -68.87787  -0.70174  -91.92111  1.000 27.22156 ? 317 GLU B CG  1 
ATOM   5345 C CD  . GLU B 1 317 ? -68.26197  -0.41590  -90.56328  1.000 35.05018 ? 317 GLU B CD  1 
ATOM   5346 O OE1 . GLU B 1 317 ? -67.56222  -1.30629  -90.01995  1.000 35.91448 ? 317 GLU B OE1 1 
ATOM   5347 O OE2 . GLU B 1 317 ? -68.48769  0.70389   -90.04152  1.000 31.66066 ? 317 GLU B OE2 1 
ATOM   5348 N N   . GLN B 1 318 ? -66.84742  0.10561   -96.16341  1.000 31.35942 ? 318 GLN B N   1 
ATOM   5349 C CA  . GLN B 1 318 ? -66.30870  0.91924   -97.24227  1.000 33.90478 ? 318 GLN B CA  1 
ATOM   5350 C C   . GLN B 1 318 ? -66.74915  0.41414   -98.61105  1.000 37.81525 ? 318 GLN B C   1 
ATOM   5351 O O   . GLN B 1 318 ? -66.24332  0.89237   -99.63370  1.000 42.14652 ? 318 GLN B O   1 
ATOM   5352 C CB  . GLN B 1 318 ? -64.77973  0.95355   -97.15797  1.000 35.66158 ? 318 GLN B CB  1 
ATOM   5353 C CG  . GLN B 1 318 ? -64.21810  1.79325   -96.00780  1.000 35.36898 ? 318 GLN B CG  1 
ATOM   5354 C CD  . GLN B 1 318 ? -64.38092  1.13742   -94.64496  1.000 40.64954 ? 318 GLN B CD  1 
ATOM   5355 O OE1 . GLN B 1 318 ? -64.05140  -0.03673  -94.46067  1.000 40.60588 ? 318 GLN B OE1 1 
ATOM   5356 N NE2 . GLN B 1 318 ? -64.88923  1.90067   -93.67697  1.000 42.84750 ? 318 GLN B NE2 1 
ATOM   5357 N N   . HIS B 1 319 ? -67.67561  -0.54930  -98.64552  1.000 34.18704 ? 319 HIS B N   1 
ATOM   5358 C CA  . HIS B 1 319 ? -68.22113  -1.14157  -99.86820  1.000 34.00652 ? 319 HIS B CA  1 
ATOM   5359 C C   . HIS B 1 319 ? -67.17538  -1.93869  -100.63621 1.000 32.39466 ? 319 HIS B C   1 
ATOM   5360 O O   . HIS B 1 319 ? -67.32683  -2.17308  -101.84301 1.000 28.93261 ? 319 HIS B O   1 
ATOM   5361 C CB  . HIS B 1 319 ? -68.86523  -0.08890  -100.78643 1.000 25.19272 ? 319 HIS B CB  1 
ATOM   5362 C CG  . HIS B 1 319 ? -69.95090  0.71574   -100.12926 1.000 32.59287 ? 319 HIS B CG  1 
ATOM   5363 N ND1 . HIS B 1 319 ? -70.65368  1.69973   -100.79230 1.000 30.87691 ? 319 HIS B ND1 1 
ATOM   5364 C CD2 . HIS B 1 319 ? -70.45002  0.68437   -98.87026  1.000 26.28194 ? 319 HIS B CD2 1 
ATOM   5365 C CE1 . HIS B 1 319 ? -71.54219  2.23274   -99.97368  1.000 30.46030 ? 319 HIS B CE1 1 
ATOM   5366 N NE2 . HIS B 1 319 ? -71.43531  1.63810   -98.79924  1.000 33.14328 ? 319 HIS B NE2 1 
ATOM   5367 N N   . LYS B 1 320 ? -66.11107  -2.35866  -99.95827  1.000 29.80628 ? 320 LYS B N   1 
ATOM   5368 C CA  . LYS B 1 320 ? -65.08237  -3.24329  -100.48736 1.000 26.34469 ? 320 LYS B CA  1 
ATOM   5369 C C   . LYS B 1 320 ? -65.44681  -4.70015  -100.20801 1.000 24.86046 ? 320 LYS B C   1 
ATOM   5370 O O   . LYS B 1 320 ? -65.99472  -5.00866  -99.14708  1.000 26.77845 ? 320 LYS B O   1 
ATOM   5371 C CB  . LYS B 1 320 ? -63.73379  -2.92950  -99.85376  1.000 30.97482 ? 320 LYS B CB  1 
ATOM   5372 C CG  . LYS B 1 320 ? -63.28151  -1.49265  -100.05022 1.000 37.43168 ? 320 LYS B CG  1 
ATOM   5373 C CD  . LYS B 1 320 ? -63.30694  -1.09735  -101.51991 1.000 40.36680 ? 320 LYS B CD  1 
ATOM   5374 C CE  . LYS B 1 320 ? -62.62328  0.24794   -101.73558 1.000 45.28005 ? 320 LYS B CE  1 
ATOM   5375 N NZ  . LYS B 1 320 ? -62.48418  0.55271   -103.19115 1.000 57.67190 ? 320 LYS B NZ  1 
ATOM   5376 N N   . PRO B 1 321 ? -65.14307  -5.61144  -101.12693 1.000 27.81746 ? 321 PRO B N   1 
ATOM   5377 C CA  . PRO B 1 321 ? -65.46135  -7.02954  -100.90167 1.000 28.76643 ? 321 PRO B CA  1 
ATOM   5378 C C   . PRO B 1 321 ? -64.70396  -7.60401  -99.71284  1.000 31.73695 ? 321 PRO B C   1 
ATOM   5379 O O   . PRO B 1 321 ? -63.50403  -7.38529  -99.55051  1.000 29.33946 ? 321 PRO B O   1 
ATOM   5380 C CB  . PRO B 1 321 ? -65.03226  -7.70367  -102.20895 1.000 24.64190 ? 321 PRO B CB  1 
ATOM   5381 C CG  . PRO B 1 321 ? -64.09476  -6.76037  -102.84151 1.000 29.87763 ? 321 PRO B CG  1 
ATOM   5382 C CD  . PRO B 1 321 ? -64.50063  -5.38223  -102.42762 1.000 27.49438 ? 321 PRO B CD  1 
ATOM   5383 N N   . LYS B 1 322 ? -65.42291  -8.33733  -98.88229  1.000 33.39774 ? 322 LYS B N   1 
ATOM   5384 C CA  . LYS B 1 322 ? -64.85240  -9.08662  -97.77495  1.000 25.38792 ? 322 LYS B CA  1 
ATOM   5385 C C   . LYS B 1 322 ? -64.49695  -10.48949 -98.23940  1.000 28.15470 ? 322 LYS B C   1 
ATOM   5386 O O   . LYS B 1 322 ? -64.90350  -10.92933 -99.32413  1.000 25.39874 ? 322 LYS B O   1 
ATOM   5387 C CB  . LYS B 1 322 ? -65.84957  -9.13014  -96.61836  1.000 29.03383 ? 322 LYS B CB  1 
ATOM   5388 C CG  . LYS B 1 322 ? -66.23344  -7.77335  -96.05170  1.000 34.96821 ? 322 LYS B CG  1 
ATOM   5389 C CD  . LYS B 1 322 ? -67.56741  -7.83921  -95.31931  1.000 27.30583 ? 322 LYS B CD  1 
ATOM   5390 C CE  . LYS B 1 322 ? -67.47207  -8.65803  -94.04260  1.000 24.28704 ? 322 LYS B CE  1 
ATOM   5391 N NZ  . LYS B 1 322 ? -68.82433  -8.92763  -93.46783  1.000 26.04901 ? 322 LYS B NZ  1 
ATOM   5392 N N   . PRO B 1 323 ? -63.70484  -11.22378 -97.45336  1.000 25.55017 ? 323 PRO B N   1 
ATOM   5393 C CA  . PRO B 1 323 ? -63.45845  -12.63184 -97.80042  1.000 24.66018 ? 323 PRO B CA  1 
ATOM   5394 C C   . PRO B 1 323 ? -64.72846  -13.40994 -98.10615  1.000 22.73816 ? 323 PRO B C   1 
ATOM   5395 O O   . PRO B 1 323 ? -64.71778  -14.27330 -98.99690  1.000 24.96167 ? 323 PRO B O   1 
ATOM   5396 C CB  . PRO B 1 323 ? -62.73665  -13.15853 -96.55286  1.000 23.17053 ? 323 PRO B CB  1 
ATOM   5397 C CG  . PRO B 1 323 ? -61.93279  -11.96988 -96.10087  1.000 21.77782 ? 323 PRO B CG  1 
ATOM   5398 C CD  . PRO B 1 323 ? -62.79380  -10.75733 -96.38843  1.000 27.38057 ? 323 PRO B CD  1 
ATOM   5399 N N   . ALA B 1 324 ? -65.82200  -13.12787 -97.37961  1.000 24.49812 ? 324 ALA B N   1 
ATOM   5400 C CA  . ALA B 1 324 ? -67.10957  -13.75291 -97.67645  1.000 26.21764 ? 324 ALA B CA  1 
ATOM   5401 C C   . ALA B 1 324 ? -67.49076  -13.57842 -99.14448  1.000 20.97106 ? 324 ALA B C   1 
ATOM   5402 O O   . ALA B 1 324 ? -67.94592  -14.53543 -99.78612  1.000 26.52638 ? 324 ALA B O   1 
ATOM   5403 C CB  . ALA B 1 324 ? -68.19883  -13.18274 -96.76707  1.000 21.45394 ? 324 ALA B CB  1 
ATOM   5404 N N   . PHE B 1 325 ? -67.27925  -12.37590 -99.70176  1.000 15.59293 ? 325 PHE B N   1 
ATOM   5405 C CA  . PHE B 1 325 ? -67.57812  -12.14096 -101.11317 1.000 18.93815 ? 325 PHE B CA  1 
ATOM   5406 C C   . PHE B 1 325 ? -66.80090  -13.08891 -102.00687 1.000 25.05891 ? 325 PHE B C   1 
ATOM   5407 O O   . PHE B 1 325 ? -67.36825  -13.70039 -102.92300 1.000 28.96979 ? 325 PHE B O   1 
ATOM   5408 C CB  . PHE B 1 325 ? -67.26642  -10.69297 -101.50790 1.000 25.20530 ? 325 PHE B CB  1 
ATOM   5409 C CG  . PHE B 1 325 ? -67.41607  -10.41378 -103.00363 1.000 24.15161 ? 325 PHE B CG  1 
ATOM   5410 C CD1 . PHE B 1 325 ? -68.65761  -10.10479 -103.54810 1.000 30.24051 ? 325 PHE B CD1 1 
ATOM   5411 C CD2 . PHE B 1 325 ? -66.31058  -10.46072 -103.85781 1.000 25.91066 ? 325 PHE B CD2 1 
ATOM   5412 C CE1 . PHE B 1 325 ? -68.80664  -9.84945  -104.91554 1.000 30.23268 ? 325 PHE B CE1 1 
ATOM   5413 C CE2 . PHE B 1 325 ? -66.43756  -10.20005 -105.21828 1.000 30.16565 ? 325 PHE B CE2 1 
ATOM   5414 C CZ  . PHE B 1 325 ? -67.70019  -9.89599  -105.75578 1.000 31.28740 ? 325 PHE B CZ  1 
ATOM   5415 N N   . TRP B 1 326 ? -65.48672  -13.20744 -101.77179 1.000 28.90064 ? 326 TRP B N   1 
ATOM   5416 C CA  . TRP B 1 326 ? -64.65587  -14.00160 -102.67262 1.000 24.51320 ? 326 TRP B CA  1 
ATOM   5417 C C   . TRP B 1 326 ? -64.97476  -15.49109 -102.56325 1.000 21.65789 ? 326 TRP B C   1 
ATOM   5418 O O   . TRP B 1 326 ? -65.05760  -16.18529 -103.58296 1.000 29.36388 ? 326 TRP B O   1 
ATOM   5419 C CB  . TRP B 1 326 ? -63.18112  -13.69045 -102.41544 1.000 26.22489 ? 326 TRP B CB  1 
ATOM   5420 C CG  . TRP B 1 326 ? -62.86887  -12.31117 -102.89966 1.000 25.50603 ? 326 TRP B CG  1 
ATOM   5421 C CD1 . TRP B 1 326 ? -62.53448  -11.21961 -102.14317 1.000 25.61461 ? 326 TRP B CD1 1 
ATOM   5422 C CD2 . TRP B 1 326 ? -62.93820  -11.85511 -104.25525 1.000 19.51797 ? 326 TRP B CD2 1 
ATOM   5423 N NE1 . TRP B 1 326 ? -62.35243  -10.11590 -102.95492 1.000 21.68995 ? 326 TRP B NE1 1 
ATOM   5424 C CE2 . TRP B 1 326 ? -62.60049  -10.48475 -104.25522 1.000 21.19486 ? 326 TRP B CE2 1 
ATOM   5425 C CE3 . TRP B 1 326 ? -63.20982  -12.48499 -105.47648 1.000 23.61084 ? 326 TRP B CE3 1 
ATOM   5426 C CZ2 . TRP B 1 326 ? -62.54707  -9.73054  -105.42917 1.000 27.97753 ? 326 TRP B CZ2 1 
ATOM   5427 C CZ3 . TRP B 1 326 ? -63.14799  -11.73581 -106.64290 1.000 25.31766 ? 326 TRP B CZ3 1 
ATOM   5428 C CH2 . TRP B 1 326 ? -62.82370  -10.37048 -106.60818 1.000 29.88159 ? 326 TRP B CH2 1 
ATOM   5429 N N   . ARG B 1 327 ? -65.23343  -15.98925 -101.35271 1.000 25.08019 ? 327 ARG B N   1 
ATOM   5430 C CA  . ARG B 1 327 ? -65.64865  -17.38752 -101.22786 1.000 25.09838 ? 327 ARG B CA  1 
ATOM   5431 C C   . ARG B 1 327 ? -67.03111  -17.61961 -101.83197 1.000 25.52453 ? 327 ARG B C   1 
ATOM   5432 O O   . ARG B 1 327 ? -67.28712  -18.68235 -102.40961 1.000 29.50922 ? 327 ARG B O   1 
ATOM   5433 C CB  . ARG B 1 327 ? -65.63127  -17.83385 -99.75967  1.000 25.93713 ? 327 ARG B CB  1 
ATOM   5434 C CG  . ARG B 1 327 ? -64.27995  -17.69999 -99.02266  1.000 31.60513 ? 327 ARG B CG  1 
ATOM   5435 C CD  . ARG B 1 327 ? -63.08915  -18.19308 -99.84576  1.000 33.50652 ? 327 ARG B CD  1 
ATOM   5436 N NE  . ARG B 1 327 ? -63.12335  -19.64772 -100.02029 1.000 42.11222 ? 327 ARG B NE  1 
ATOM   5437 C CZ  . ARG B 1 327 ? -62.65686  -20.28140 -101.09747 1.000 40.54514 ? 327 ARG B CZ  1 
ATOM   5438 N NH1 . ARG B 1 327 ? -62.11460  -19.58661 -102.09682 1.000 33.55116 ? 327 ARG B NH1 1 
ATOM   5439 N NH2 . ARG B 1 327 ? -62.74333  -21.60565 -101.18554 1.000 32.09942 ? 327 ARG B NH2 1 
ATOM   5440 N N   . ALA B 1 328 ? -67.94066  -16.64504 -101.72092 1.000 28.12059 ? 328 ALA B N   1 
ATOM   5441 C CA  . ALA B 1 328 ? -69.28946  -16.86255 -102.25405 1.000 31.94392 ? 328 ALA B CA  1 
ATOM   5442 C C   . ALA B 1 328 ? -69.27581  -17.01674 -103.77375 1.000 25.52165 ? 328 ALA B C   1 
ATOM   5443 O O   . ALA B 1 328 ? -69.96673  -17.88477 -104.32093 1.000 36.39068 ? 328 ALA B O   1 
ATOM   5444 C CB  . ALA B 1 328 ? -70.22546  -15.72262 -101.84713 1.000 29.63400 ? 328 ALA B CB  1 
ATOM   5445 N N   . VAL B 1 329 ? -68.49537  -16.18759 -104.47692 1.000 32.16531 ? 329 VAL B N   1 
ATOM   5446 C CA  . VAL B 1 329 ? -68.46263  -16.24784 -105.93869 1.000 33.88682 ? 329 VAL B CA  1 
ATOM   5447 C C   . VAL B 1 329 ? -67.54907  -17.33754 -106.45838 1.000 35.09590 ? 329 VAL B C   1 
ATOM   5448 O O   . VAL B 1 329 ? -67.47147  -17.53830 -107.67808 1.000 42.67680 ? 329 VAL B O   1 
ATOM   5449 C CB  . VAL B 1 329 ? -68.01472  -14.90788 -106.55303 1.000 30.22509 ? 329 VAL B CB  1 
ATOM   5450 C CG1 . VAL B 1 329 ? -68.97088  -13.81238 -106.13151 1.000 30.26866 ? 329 VAL B CG1 1 
ATOM   5451 C CG2 . VAL B 1 329 ? -66.61378  -14.56964 -106.12429 1.000 26.00026 ? 329 VAL B CG2 1 
ATOM   5452 N N   . SER B 1 330 ? -66.84619  -18.04132 -105.56615 1.000 37.64043 ? 330 SER B N   1 
ATOM   5453 C CA  . SER B 1 330 ? -65.93067  -19.09713 -105.96214 1.000 31.28011 ? 330 SER B CA  1 
ATOM   5454 C C   . SER B 1 330 ? -66.64380  -20.41330 -106.21684 1.000 35.79647 ? 330 SER B C   1 
ATOM   5455 O O   . SER B 1 330 ? -66.03431  -21.32748 -106.78232 1.000 36.87688 ? 330 SER B O   1 
ATOM   5456 C CB  . SER B 1 330 ? -64.86231  -19.29309 -104.87919 1.000 27.63490 ? 330 SER B CB  1 
ATOM   5457 O OG  . SER B 1 330 ? -65.32818  -20.09107 -103.80026 1.000 32.98396 ? 330 SER B OG  1 
ATOM   5458 N N   . VAL B 1 331 ? -67.91704  -20.53087 -105.82474 1.000 32.21515 ? 331 VAL B N   1 
ATOM   5459 C CA  . VAL B 1 331 ? -68.61948  -21.81685 -105.90901 1.000 36.67029 ? 331 VAL B CA  1 
ATOM   5460 C C   . VAL B 1 331 ? -69.01173  -22.19073 -107.33267 1.000 41.52418 ? 331 VAL B C   1 
ATOM   5461 O O   . VAL B 1 331 ? -69.32544  -23.35887 -107.54638 1.000 38.43775 ? 331 VAL B O   1 
ATOM   5462 C CB  . VAL B 1 331 ? -69.85989  -21.83546 -104.99929 1.000 41.73258 ? 331 VAL B CB  1 
ATOM   5463 C CG1 . VAL B 1 331 ? -69.48207  -21.42931 -103.58525 1.000 40.03866 ? 331 VAL B CG1 1 
ATOM   5464 C CG2 . VAL B 1 331 ? -70.98566  -20.94776 -105.56955 1.000 38.89792 ? 331 VAL B CG2 1 
ATOM   5465 O OXT . VAL B 1 331 ? -69.02643  -21.35573 -108.24410 1.000 49.64030 ? 331 VAL B OXT 1 
HETATM 5466 O O   . HOH C 2 .   ? -37.75054  7.57865   -101.53128 1.000 47.26796 ? 401 HOH A O   1 
HETATM 5467 O O   . HOH C 2 .   ? -40.12467  8.78562   -101.40984 1.000 47.22550 ? 402 HOH A O   1 
HETATM 5468 O O   . HOH C 2 .   ? -51.67710  -28.59444 -114.37114 1.000 22.24989 ? 403 HOH A O   1 
HETATM 5469 O O   . HOH C 2 .   ? -22.41580  -12.46486 -117.47753 1.000 42.58818 ? 404 HOH A O   1 
HETATM 5470 O O   . HOH C 2 .   ? -5.25338   -22.40541 -118.13716 1.000 50.23193 ? 405 HOH A O   1 
HETATM 5471 O O   . HOH C 2 .   ? -10.17244  -26.47042 -100.88544 1.000 36.38516 ? 406 HOH A O   1 
HETATM 5472 O O   . HOH C 2 .   ? -23.70639  -39.47054 -114.06027 1.000 38.38652 ? 407 HOH A O   1 
HETATM 5473 O O   . HOH C 2 .   ? -54.99242  -30.53802 -116.87378 1.000 44.50744 ? 408 HOH A O   1 
HETATM 5474 O O   . HOH C 2 .   ? -58.13593  -27.36626 -107.70526 1.000 32.42559 ? 409 HOH A O   1 
HETATM 5475 O O   . HOH C 2 .   ? -40.81081  -9.72481  -115.56863 1.000 20.98158 ? 410 HOH A O   1 
HETATM 5476 O O   . HOH C 2 .   ? -30.11145  -37.71543 -100.26355 1.000 38.62706 ? 411 HOH A O   1 
HETATM 5477 O O   . HOH C 2 .   ? -46.24727  -33.11462 -109.50339 1.000 41.14813 ? 412 HOH A O   1 
HETATM 5478 O O   . HOH C 2 .   ? -24.34435  -15.27567 -102.37399 1.000 37.21203 ? 413 HOH A O   1 
HETATM 5479 O O   . HOH C 2 .   ? -58.39707  -16.33669 -117.24069 1.000 42.14652 ? 414 HOH A O   1 
HETATM 5480 O O   . HOH C 2 .   ? -33.35572  4.88783   -104.40326 1.000 31.85657 ? 415 HOH A O   1 
HETATM 5481 O O   . HOH C 2 .   ? -43.65760  -5.33810  -122.44717 1.000 38.43437 ? 416 HOH A O   1 
HETATM 5482 O O   . HOH C 2 .   ? -19.63362  -17.74052 -105.33720 1.000 39.69254 ? 417 HOH A O   1 
HETATM 5483 O O   . HOH C 2 .   ? -51.11724  -7.11277  -92.64348  1.000 33.77358 ? 418 HOH A O   1 
HETATM 5484 O O   . HOH C 2 .   ? -31.21180  -39.61296 -103.33332 1.000 33.01621 ? 419 HOH A O   1 
HETATM 5485 O O   . HOH C 2 .   ? -27.63748  -42.74546 -116.46850 1.000 25.61114 ? 420 HOH A O   1 
HETATM 5486 O O   . HOH C 2 .   ? -43.02741  -24.32360 -109.52896 1.000 21.92445 ? 421 HOH A O   1 
HETATM 5487 O O   . HOH C 2 .   ? -31.88929  -13.61501 -118.26817 1.000 20.42324 ? 422 HOH A O   1 
HETATM 5488 O O   . HOH C 2 .   ? -56.84673  -9.51207  -121.94317 1.000 48.94652 ? 423 HOH A O   1 
HETATM 5489 O O   . HOH C 2 .   ? -29.48835  -35.87185 -98.37084  1.000 23.71223 ? 424 HOH A O   1 
HETATM 5490 O O   . HOH C 2 .   ? -43.26740  -28.26386 -108.05456 1.000 18.18005 ? 425 HOH A O   1 
HETATM 5491 O O   . HOH C 2 .   ? -44.16515  1.67485   -108.49812 1.000 32.25337 ? 426 HOH A O   1 
HETATM 5492 O O   . HOH C 2 .   ? -41.37260  -9.59965  -108.16125 1.000 28.52251 ? 427 HOH A O   1 
HETATM 5493 O O   . HOH C 2 .   ? -26.15375  -24.83249 -126.05753 1.000 41.13159 ? 428 HOH A O   1 
HETATM 5494 O O   . HOH C 2 .   ? -46.69395  -6.88884  -93.33188  1.000 41.27319 ? 429 HOH A O   1 
HETATM 5495 O O   . HOH C 2 .   ? -23.61923  -36.98193 -115.42686 1.000 32.57845 ? 430 HOH A O   1 
HETATM 5496 O O   . HOH C 2 .   ? -9.68033   -25.91182 -107.81414 1.000 37.58809 ? 431 HOH A O   1 
HETATM 5497 O O   . HOH C 2 .   ? -33.58339  -35.88309 -116.75444 1.000 29.15990 ? 432 HOH A O   1 
HETATM 5498 O O   . HOH C 2 .   ? -53.01147  -7.56961  -114.44651 1.000 30.82253 ? 433 HOH A O   1 
HETATM 5499 O O   . HOH C 2 .   ? -32.27404  -9.71324  -101.93363 1.000 28.93495 ? 434 HOH A O   1 
HETATM 5500 O O   . HOH C 2 .   ? -50.59638  -21.59154 -91.41376  1.000 31.07717 ? 435 HOH A O   1 
HETATM 5501 O O   . HOH C 2 .   ? -36.73726  -18.51512 -98.15994  1.000 32.03166 ? 436 HOH A O   1 
HETATM 5502 O O   . HOH C 2 .   ? -33.77415  -26.26755 -104.80232 1.000 19.40841 ? 437 HOH A O   1 
HETATM 5503 O O   . HOH C 2 .   ? -40.53145  -12.80588 -102.82488 1.000 19.39644 ? 438 HOH A O   1 
HETATM 5504 O O   . HOH C 2 .   ? -40.05044  -0.04132  -98.53488  1.000 29.71916 ? 439 HOH A O   1 
HETATM 5505 O O   . HOH C 2 .   ? -52.23595  -28.55637 -92.42246  1.000 37.53652 ? 440 HOH A O   1 
HETATM 5506 O O   . HOH C 2 .   ? -24.40387  -24.43257 -98.18840  1.000 29.78313 ? 441 HOH A O   1 
HETATM 5507 O O   . HOH C 2 .   ? -47.50330  -0.36868  -109.86421 1.000 32.81376 ? 442 HOH A O   1 
HETATM 5508 O O   . HOH C 2 .   ? -36.91055  -37.41569 -117.46550 1.000 32.15774 ? 443 HOH A O   1 
HETATM 5509 O O   . HOH C 2 .   ? -30.79393  -22.91727 -104.11441 1.000 19.88602 ? 444 HOH A O   1 
HETATM 5510 O O   . HOH C 2 .   ? -45.39840  -30.89674 -110.76897 1.000 29.62755 ? 445 HOH A O   1 
HETATM 5511 O O   . HOH C 2 .   ? -33.24201  -35.40696 -109.55656 1.000 23.43646 ? 446 HOH A O   1 
HETATM 5512 O O   . HOH C 2 .   ? -26.47120  -33.36805 -93.90642  1.000 29.65083 ? 447 HOH A O   1 
HETATM 5513 O O   . HOH C 2 .   ? -59.34014  -10.63407 -109.51667 1.000 41.36180 ? 448 HOH A O   1 
HETATM 5514 O O   . HOH C 2 .   ? -39.27737  -36.53549 -112.26510 1.000 33.08766 ? 449 HOH A O   1 
HETATM 5515 O O   . HOH C 2 .   ? -39.57535  -34.09796 -105.61012 1.000 20.94188 ? 450 HOH A O   1 
HETATM 5516 O O   . HOH C 2 .   ? -33.68560  -13.69383 -99.33543  1.000 31.47447 ? 451 HOH A O   1 
HETATM 5517 O O   . HOH C 2 .   ? -38.40328  -9.46791  -113.17217 1.000 26.56962 ? 452 HOH A O   1 
HETATM 5518 O O   . HOH C 2 .   ? -36.19250  -11.28273 -129.68140 1.000 31.75278 ? 453 HOH A O   1 
HETATM 5519 O O   . HOH C 2 .   ? -53.54060  -9.52266  -93.67870  1.000 36.84464 ? 454 HOH A O   1 
HETATM 5520 O O   . HOH C 2 .   ? -39.32494  -5.02827  -107.37899 1.000 19.82086 ? 455 HOH A O   1 
HETATM 5521 O O   . HOH C 2 .   ? -41.18587  -15.98708 -97.36478  1.000 27.13754 ? 456 HOH A O   1 
HETATM 5522 O O   . HOH C 2 .   ? -41.87011  -2.57969  -113.84002 1.000 26.74725 ? 457 HOH A O   1 
HETATM 5523 O O   . HOH C 2 .   ? -41.33503  -25.50982 -105.15497 1.000 19.84166 ? 458 HOH A O   1 
HETATM 5524 O O   . HOH C 2 .   ? -15.47017  -31.92651 -107.93845 1.000 25.22143 ? 459 HOH A O   1 
HETATM 5525 O O   . HOH C 2 .   ? -40.10862  -12.36163 -114.42666 1.000 22.07701 ? 460 HOH A O   1 
HETATM 5526 O O   . HOH C 2 .   ? -42.35063  -24.92329 -133.56022 1.000 54.15686 ? 461 HOH A O   1 
HETATM 5527 O O   . HOH C 2 .   ? -25.31114  -17.22170 -121.17575 1.000 36.35707 ? 462 HOH A O   1 
HETATM 5528 O O   . HOH C 2 .   ? -45.25134  -5.14469  -119.47550 1.000 26.06393 ? 463 HOH A O   1 
HETATM 5529 O O   . HOH C 2 .   ? -32.44000  -14.80355 -102.57657 1.000 44.63652 ? 464 HOH A O   1 
HETATM 5530 O O   . HOH C 2 .   ? -51.15201  -8.59962  -89.56835  1.000 43.72025 ? 465 HOH A O   1 
HETATM 5531 O O   . HOH C 2 .   ? -54.37611  -17.16438 -90.13636  1.000 39.85516 ? 466 HOH A O   1 
HETATM 5532 O O   . HOH C 2 .   ? -51.79376  -28.46686 -105.45998 1.000 24.83952 ? 467 HOH A O   1 
HETATM 5533 O O   . HOH C 2 .   ? -10.21642  -27.36159 -103.64351 1.000 32.69799 ? 468 HOH A O   1 
HETATM 5534 O O   . HOH C 2 .   ? -26.57612  -17.74695 -116.85195 1.000 31.39683 ? 469 HOH A O   1 
HETATM 5535 O O   . HOH C 2 .   ? -19.60781  -20.06351 -101.01356 1.000 42.37886 ? 470 HOH A O   1 
HETATM 5536 O O   . HOH C 2 .   ? -45.23565  -12.46969 -123.91596 1.000 27.18678 ? 471 HOH A O   1 
HETATM 5537 O O   . HOH C 2 .   ? -52.70244  -20.49396 -92.82559  1.000 29.74160 ? 472 HOH A O   1 
HETATM 5538 O O   . HOH C 2 .   ? -36.78133  -19.62320 -110.15885 1.000 25.81652 ? 473 HOH A O   1 
HETATM 5539 O O   . HOH C 2 .   ? -46.51889  0.57353   -107.54142 1.000 37.39325 ? 474 HOH A O   1 
HETATM 5540 O O   . HOH C 2 .   ? -38.91018  -22.91819 -107.83966 1.000 18.14844 ? 475 HOH A O   1 
HETATM 5541 O O   . HOH C 2 .   ? -47.93448  -7.54419  -95.76773  1.000 32.52060 ? 476 HOH A O   1 
HETATM 5542 O O   . HOH C 2 .   ? -46.45600  -6.50819  -125.58395 1.000 42.33652 ? 477 HOH A O   1 
HETATM 5543 O O   . HOH C 2 .   ? -31.30241  -34.75352 -107.90256 1.000 20.84949 ? 478 HOH A O   1 
HETATM 5544 O O   . HOH C 2 .   ? -41.05195  -26.44787 -84.83208  1.000 52.69595 ? 479 HOH A O   1 
HETATM 5545 O O   . HOH C 2 .   ? -25.69241  -26.08582 -107.89548 1.000 23.17215 ? 480 HOH A O   1 
HETATM 5546 O O   . HOH C 2 .   ? -47.58530  -3.85456  -118.53608 1.000 34.39249 ? 481 HOH A O   1 
HETATM 5547 O O   . HOH C 2 .   ? -35.74955  -3.53414  -103.15030 1.000 27.55281 ? 482 HOH A O   1 
HETATM 5548 O O   . HOH C 2 .   ? -38.11602  -1.27746  -107.99406 1.000 25.03887 ? 483 HOH A O   1 
HETATM 5549 O O   . HOH C 2 .   ? -49.74202  -23.16617 -127.18779 1.000 31.43316 ? 484 HOH A O   1 
HETATM 5550 O O   . HOH C 2 .   ? -42.20617  -17.01423 -86.88456  1.000 41.64782 ? 485 HOH A O   1 
HETATM 5551 O O   . HOH C 2 .   ? -27.47202  -11.02320 -113.34983 1.000 32.41391 ? 486 HOH A O   1 
HETATM 5552 O O   . HOH C 2 .   ? -33.60637  -13.71519 -110.91746 1.000 33.50685 ? 487 HOH A O   1 
HETATM 5553 O O   . HOH C 2 .   ? -24.13384  -38.09893 -96.82564  1.000 21.66445 ? 488 HOH A O   1 
HETATM 5554 O O   . HOH C 2 .   ? -51.02969  -16.12505 -128.17453 1.000 40.42320 ? 489 HOH A O   1 
HETATM 5555 O O   . HOH C 2 .   ? -20.92753  -23.87942 -98.26927  1.000 35.96187 ? 490 HOH A O   1 
HETATM 5556 O O   . HOH C 2 .   ? -18.02138  -36.77121 -106.69934 1.000 26.30403 ? 491 HOH A O   1 
HETATM 5557 O O   . HOH C 2 .   ? -59.86459  -26.66717 -111.73419 1.000 34.49128 ? 492 HOH A O   1 
HETATM 5558 O O   . HOH C 2 .   ? -0.62110   -15.71756 -112.01573 1.000 49.45529 ? 493 HOH A O   1 
HETATM 5559 O O   . HOH C 2 .   ? -51.17361  -1.77704  -111.85509 1.000 34.99405 ? 494 HOH A O   1 
HETATM 5560 O O   . HOH C 2 .   ? -36.59713  -10.55403 -96.28852  1.000 30.11429 ? 495 HOH A O   1 
HETATM 5561 O O   . HOH C 2 .   ? -48.23185  -16.92371 -128.16150 1.000 31.17050 ? 496 HOH A O   1 
HETATM 5562 O O   . HOH C 2 .   ? -39.26931  -30.02927 -89.19597  1.000 45.95812 ? 497 HOH A O   1 
HETATM 5563 O O   . HOH C 2 .   ? -24.70444  -18.22706 -118.99538 1.000 27.38678 ? 498 HOH A O   1 
HETATM 5564 O O   . HOH C 2 .   ? -24.04471  -22.32288 -111.50239 1.000 25.05611 ? 499 HOH A O   1 
HETATM 5565 O O   . HOH C 2 .   ? -60.82659  -22.18040 -106.32210 1.000 41.98307 ? 500 HOH A O   1 
HETATM 5566 O O   . HOH C 2 .   ? -51.17704  -4.67493  -116.62085 1.000 31.65133 ? 501 HOH A O   1 
HETATM 5567 O O   . HOH C 2 .   ? -26.27595  -27.00906 -98.97694  1.000 21.18460 ? 502 HOH A O   1 
HETATM 5568 O O   . HOH C 2 .   ? -53.45528  -31.59068 -98.53506  1.000 42.32653 ? 503 HOH A O   1 
HETATM 5569 O O   . HOH C 2 .   ? -55.10140  -12.20121 -121.37059 1.000 31.62973 ? 504 HOH A O   1 
HETATM 5570 O O   . HOH C 2 .   ? -55.61394  -25.68784 -119.71943 1.000 36.05865 ? 505 HOH A O   1 
HETATM 5571 O O   . HOH C 2 .   ? -38.22587  -16.62803 -131.68911 1.000 34.00134 ? 506 HOH A O   1 
HETATM 5572 O O   . HOH C 2 .   ? -56.74651  -2.26946  -99.87025  1.000 39.26129 ? 507 HOH A O   1 
HETATM 5573 O O   . HOH C 2 .   ? -59.81293  -19.19349 -114.92074 1.000 33.51655 ? 508 HOH A O   1 
HETATM 5574 O O   . HOH C 2 .   ? -38.28266  -4.62692  -104.79368 1.000 25.68982 ? 509 HOH A O   1 
HETATM 5575 O O   . HOH C 2 .   ? -47.52626  -16.40729 -100.70265 1.000 19.88271 ? 510 HOH A O   1 
HETATM 5576 O O   . HOH C 2 .   ? -37.61947  -37.61675 -120.36237 1.000 39.21004 ? 511 HOH A O   1 
HETATM 5577 O O   . HOH C 2 .   ? -54.56701  -29.47215 -96.02576  1.000 42.02321 ? 512 HOH A O   1 
HETATM 5578 O O   . HOH C 2 .   ? -39.71903  2.42431   -99.88766  1.000 38.96998 ? 513 HOH A O   1 
HETATM 5579 O O   . HOH C 2 .   ? -13.22064  -17.25871 -112.41457 1.000 47.53101 ? 514 HOH A O   1 
HETATM 5580 O O   . HOH C 2 .   ? -36.132    -39.637   -120.893   1.000 38.94584 ? 515 HOH A O   1 
HETATM 5581 O O   . HOH C 2 .   ? -31.36450  -17.90027 -98.25949  1.000 30.18580 ? 516 HOH A O   1 
HETATM 5582 O O   . HOH C 2 .   ? -40.64561  -6.98540  -111.20423 1.000 18.97848 ? 517 HOH A O   1 
HETATM 5583 O O   . HOH C 2 .   ? -28.83673  -14.62226 -103.19145 1.000 39.01395 ? 518 HOH A O   1 
HETATM 5584 O O   . HOH C 2 .   ? -13.24742  -19.47452 -105.83067 1.000 34.12033 ? 519 HOH A O   1 
HETATM 5585 O O   . HOH C 2 .   ? -46.05079  -20.56237 -130.98513 1.000 41.55614 ? 520 HOH A O   1 
HETATM 5586 O O   . HOH C 2 .   ? -23.02674  -22.41648 -97.66645  1.000 36.18507 ? 521 HOH A O   1 
HETATM 5587 O O   . HOH C 2 .   ? -26.96295  -13.43969 -130.64486 1.000 46.63190 ? 522 HOH A O   1 
HETATM 5588 O O   . HOH C 2 .   ? -52.76872  -6.83051  -117.22917 1.000 30.05053 ? 523 HOH A O   1 
HETATM 5589 O O   . HOH C 2 .   ? -32.36714  -10.04285 -98.72496  1.000 40.23095 ? 524 HOH A O   1 
HETATM 5590 O O   . HOH C 2 .   ? -31.93776  -22.19079 -99.52364  1.000 20.88743 ? 525 HOH A O   1 
HETATM 5591 O O   . HOH C 2 .   ? -15.75596  -23.29885 -97.67649  1.000 44.47652 ? 526 HOH A O   1 
HETATM 5592 O O   . HOH C 2 .   ? -39.79451  -29.21059 -129.21388 1.000 43.25546 ? 527 HOH A O   1 
HETATM 5593 O O   . HOH C 2 .   ? -37.33736  -14.46625 -101.07680 1.000 22.96509 ? 528 HOH A O   1 
HETATM 5594 O O   . HOH C 2 .   ? -34.51655  -21.48871 -132.86290 1.000 33.13449 ? 529 HOH A O   1 
HETATM 5595 O O   . HOH C 2 .   ? -35.76562  -13.30305 -93.07056  1.000 26.78672 ? 530 HOH A O   1 
HETATM 5596 O O   . HOH C 2 .   ? -16.76738  -29.77930 -110.09708 1.000 24.52127 ? 531 HOH A O   1 
HETATM 5597 O O   . HOH C 2 .   ? -57.68420  -11.35734 -94.52910  1.000 32.64920 ? 532 HOH A O   1 
HETATM 5598 O O   . HOH C 2 .   ? -32.39497  -17.49055 -107.62956 1.000 27.27615 ? 533 HOH A O   1 
HETATM 5599 O O   . HOH C 2 .   ? -42.35201  -7.61210  -114.31998 1.000 27.07247 ? 534 HOH A O   1 
HETATM 5600 O O   . HOH C 2 .   ? -39.87622  -1.66995  -116.51863 1.000 38.11180 ? 535 HOH A O   1 
HETATM 5601 O O   . HOH C 2 .   ? -46.02939  -19.98456 -89.86802  1.000 39.02840 ? 536 HOH A O   1 
HETATM 5602 O O   . HOH C 2 .   ? -35.65486  -6.51460  -114.75193 1.000 32.06083 ? 537 HOH A O   1 
HETATM 5603 O O   . HOH C 2 .   ? -25.59846  -21.96590 -109.29634 1.000 23.24455 ? 538 HOH A O   1 
HETATM 5604 O O   . HOH C 2 .   ? -28.37634  -9.32906  -120.09988 1.000 34.39995 ? 539 HOH A O   1 
HETATM 5605 O O   . HOH C 2 .   ? -41.82618  -32.24883 -121.75209 1.000 38.77313 ? 540 HOH A O   1 
HETATM 5606 O O   . HOH C 2 .   ? -33.70591  -9.55276  -124.23661 1.000 42.97932 ? 541 HOH A O   1 
HETATM 5607 O O   . HOH C 2 .   ? -45.53578  -2.76354  -108.85594 1.000 39.64652 ? 542 HOH A O   1 
HETATM 5608 O O   . HOH C 2 .   ? -40.58314  -4.29410  -110.59622 1.000 31.63652 ? 543 HOH A O   1 
HETATM 5609 O O   . HOH C 2 .   ? -26.72795  -16.71125 -100.63947 1.000 27.77830 ? 544 HOH A O   1 
HETATM 5610 O O   . HOH C 2 .   ? -46.92804  -28.41434 -124.00508 1.000 30.06320 ? 545 HOH A O   1 
HETATM 5611 O O   . HOH C 2 .   ? -40.87652  -9.08152  -90.74627  1.000 41.57530 ? 546 HOH A O   1 
HETATM 5612 O O   . HOH C 2 .   ? -41.88317  -38.52925 -98.73815  1.000 46.32243 ? 547 HOH A O   1 
HETATM 5613 O O   . HOH C 2 .   ? -41.80782  -18.50196 -135.23946 1.000 48.34226 ? 548 HOH A O   1 
HETATM 5614 O O   . HOH C 2 .   ? -52.87923  -7.83880  -101.41863 1.000 29.58054 ? 549 HOH A O   1 
HETATM 5615 O O   . HOH C 2 .   ? -21.69746  -13.57345 -110.51541 1.000 46.24835 ? 550 HOH A O   1 
HETATM 5616 O O   . HOH C 2 .   ? -58.73359  -26.13467 -98.61974  1.000 34.55220 ? 551 HOH A O   1 
HETATM 5617 O O   . HOH C 2 .   ? -57.13106  -13.70713 -116.04223 1.000 33.93031 ? 552 HOH A O   1 
HETATM 5618 O O   . HOH C 2 .   ? -23.63241  -37.97181 -104.89029 1.000 32.11478 ? 553 HOH A O   1 
HETATM 5619 O O   . HOH C 2 .   ? -36.20857  -38.01199 -109.61496 1.000 40.27652 ? 554 HOH A O   1 
HETATM 5620 O O   . HOH C 2 .   ? -10.67473  -20.47638 -122.05385 1.000 35.57807 ? 555 HOH A O   1 
HETATM 5621 O O   . HOH C 2 .   ? -36.67764  -22.05189 -109.04566 1.000 24.52231 ? 556 HOH A O   1 
HETATM 5622 O O   . HOH C 2 .   ? -35.780    -33.557   -126.561   1.000 42.44348 ? 557 HOH A O   1 
HETATM 5623 O O   . HOH C 2 .   ? -49.81163  -5.66305  -123.55062 1.000 31.24479 ? 558 HOH A O   1 
HETATM 5624 O O   . HOH C 2 .   ? -39.23237  -18.09049 -97.44674  1.000 29.52093 ? 559 HOH A O   1 
HETATM 5625 O O   . HOH C 2 .   ? -39.23013  -27.93385 -130.89930 1.000 46.15723 ? 560 HOH A O   1 
HETATM 5626 O O   . HOH C 2 .   ? -15.27297  -17.09356 -105.52820 1.000 35.95498 ? 561 HOH A O   1 
HETATM 5627 O O   . HOH C 2 .   ? -32.70042  -17.08867 -110.27458 1.000 31.05498 ? 562 HOH A O   1 
HETATM 5628 O O   . HOH C 2 .   ? -40.12538  -6.68737  -125.36140 1.000 37.97832 ? 563 HOH A O   1 
HETATM 5629 O O   . HOH C 2 .   ? -20.82964  -16.51787 -110.45397 1.000 34.79532 ? 564 HOH A O   1 
HETATM 5630 O O   . HOH C 2 .   ? -14.32222  -30.95108 -110.14021 1.000 28.79187 ? 565 HOH A O   1 
HETATM 5631 O O   . HOH C 2 .   ? -41.97515  -10.82007 -117.91430 1.000 27.09195 ? 566 HOH A O   1 
HETATM 5632 O O   . HOH C 2 .   ? -9.24488   -23.75355 -109.67411 1.000 42.59602 ? 567 HOH A O   1 
HETATM 5633 O O   . HOH C 2 .   ? -25.60897  -14.41719 -128.32710 1.000 39.84698 ? 568 HOH A O   1 
HETATM 5634 O O   . HOH C 2 .   ? -21.32120  -38.91195 -109.21642 1.000 36.11156 ? 569 HOH A O   1 
HETATM 5635 O O   . HOH C 2 .   ? -32.72839  -16.01213 -104.53924 1.000 37.17507 ? 570 HOH A O   1 
HETATM 5636 O O   . HOH C 2 .   ? -22.46215  -13.83601 -107.93195 1.000 38.27457 ? 571 HOH A O   1 
HETATM 5637 O O   . HOH C 2 .   ? -53.53916  -7.41256  -120.57140 1.000 32.30714 ? 572 HOH A O   1 
HETATM 5638 O O   . HOH C 2 .   ? -38.60879  -9.17006  -91.50393  1.000 47.64145 ? 573 HOH A O   1 
HETATM 5639 O O   . HOH C 2 .   ? -27.97006  -31.52011 -92.32371  1.000 35.60493 ? 574 HOH A O   1 
HETATM 5640 O O   . HOH C 2 .   ? -47.21193  -35.01536 -93.80726  1.000 47.73680 ? 575 HOH A O   1 
HETATM 5641 O O   . HOH C 2 .   ? -51.09158  -32.40813 -102.44589 1.000 43.48850 ? 576 HOH A O   1 
HETATM 5642 O O   . HOH C 2 .   ? -52.55753  -18.13234 -92.34354  1.000 32.13996 ? 577 HOH A O   1 
HETATM 5643 O O   . HOH C 2 .   ? -44.49233  -31.31462 -113.53373 1.000 21.97050 ? 578 HOH A O   1 
HETATM 5644 O O   . HOH C 2 .   ? -39.01104  -32.11664 -90.37784  1.000 43.43594 ? 579 HOH A O   1 
HETATM 5645 O O   . HOH C 2 .   ? -19.30485  -26.80389 -93.98023  1.000 32.99432 ? 580 HOH A O   1 
HETATM 5646 O O   . HOH C 2 .   ? -34.91807  -41.59756 -110.42490 1.000 43.54859 ? 581 HOH A O   1 
HETATM 5647 O O   . HOH C 2 .   ? -10.48354  -24.68226 -125.01032 1.000 36.39328 ? 582 HOH A O   1 
HETATM 5648 O O   . HOH C 2 .   ? -48.33592  -31.00896 -95.16020  1.000 40.14388 ? 583 HOH A O   1 
HETATM 5649 O O   . HOH C 2 .   ? -58.44016  -27.57941 -118.42450 1.000 42.24177 ? 584 HOH A O   1 
HETATM 5650 O O   . HOH C 2 .   ? -44.54965  -21.60916 -87.72421  1.000 37.97116 ? 585 HOH A O   1 
HETATM 5651 O O   . HOH C 2 .   ? -35.94402  -19.15685 -87.75197  1.000 44.17860 ? 586 HOH A O   1 
HETATM 5652 O O   . HOH C 2 .   ? -24.36638  -26.47094 -96.08776  1.000 39.73592 ? 587 HOH A O   1 
HETATM 5653 O O   . HOH C 2 .   ? -10.19718  -19.24307 -106.66484 1.000 42.21911 ? 588 HOH A O   1 
HETATM 5654 O O   . HOH C 2 .   ? -40.95347  -13.49246 -88.47109  1.000 41.55505 ? 589 HOH A O   1 
HETATM 5655 O O   . HOH C 2 .   ? -10.67168  -24.99505 -105.36383 1.000 31.24405 ? 590 HOH A O   1 
HETATM 5656 O O   . HOH C 2 .   ? -24.65879  -10.82655 -117.21270 1.000 44.43177 ? 591 HOH A O   1 
HETATM 5657 O O   . HOH C 2 .   ? -25.71782  -10.11431 -124.47656 1.000 46.76092 ? 592 HOH A O   1 
HETATM 5658 O O   . HOH C 2 .   ? -46.91527  4.31036   -95.60478  1.000 43.58331 ? 593 HOH A O   1 
HETATM 5659 O O   . HOH C 2 .   ? -10.07300  -27.70599 -124.25095 1.000 40.50116 ? 594 HOH A O   1 
HETATM 5660 O O   . HOH C 2 .   ? -16.20460  -35.45527 -114.78324 1.000 39.92965 ? 595 HOH A O   1 
HETATM 5661 O O   . HOH C 2 .   ? -53.50317  4.24213   -97.57819  1.000 50.12059 ? 596 HOH A O   1 
HETATM 5662 O O   . HOH C 2 .   ? -53.68027  -30.08418 -114.26789 1.000 40.39184 ? 597 HOH A O   1 
HETATM 5663 O O   . HOH C 2 .   ? -64.73467  -19.09325 -109.97252 1.000 43.17326 ? 598 HOH A O   1 
HETATM 5664 O O   . HOH C 2 .   ? -7.17529   -25.68442 -110.36428 1.000 46.26716 ? 599 HOH A O   1 
HETATM 5665 O O   . HOH C 2 .   ? -31.19101  -12.79025 -130.93369 1.000 45.81424 ? 600 HOH A O   1 
HETATM 5666 O O   . HOH C 2 .   ? -46.89036  -10.02344 -127.64837 1.000 35.92762 ? 601 HOH A O   1 
HETATM 5667 O O   . HOH C 2 .   ? -16.84212  -31.83803 -126.29976 1.000 36.66043 ? 602 HOH A O   1 
HETATM 5668 O O   . HOH C 2 .   ? -34.53898  -15.70211 -108.28412 1.000 36.87703 ? 603 HOH A O   1 
HETATM 5669 O O   . HOH C 2 .   ? -34.34526  -11.70864 -97.75840  1.000 33.13585 ? 604 HOH A O   1 
HETATM 5670 O O   . HOH C 2 .   ? -36.36158  -8.12643  -120.81333 1.000 35.51491 ? 605 HOH A O   1 
HETATM 5671 O O   . HOH C 2 .   ? -32.94585  -15.90338 -94.11888  1.000 36.97714 ? 606 HOH A O   1 
HETATM 5672 O O   . HOH C 2 .   ? -52.34532  -31.70966 -116.50147 1.000 49.16198 ? 607 HOH A O   1 
HETATM 5673 O O   . HOH C 2 .   ? -19.88857  -16.40961 -115.02777 1.000 30.97289 ? 608 HOH A O   1 
HETATM 5674 O O   . HOH C 2 .   ? -43.40982  -20.80583 -134.90726 1.000 45.47339 ? 609 HOH A O   1 
HETATM 5675 O O   . HOH C 2 .   ? -44.91396  -14.02369 -87.57542  1.000 45.41804 ? 610 HOH A O   1 
HETATM 5676 O O   . HOH C 2 .   ? -25.45257  -9.47517  -115.31993 1.000 41.78115 ? 611 HOH A O   1 
HETATM 5677 O O   . HOH C 2 .   ? -29.56548  -12.92215 -109.32567 1.000 39.26199 ? 612 HOH A O   1 
HETATM 5678 O O   . HOH C 2 .   ? -19.23015  -15.28702 -113.04461 1.000 47.26548 ? 613 HOH A O   1 
HETATM 5679 O O   . HOH C 2 .   ? -30.61100  -20.26325 -93.93208  1.000 41.14497 ? 614 HOH A O   1 
HETATM 5680 O O   . HOH C 2 .   ? -56.12271  4.96113   -98.01727  1.000 61.86059 ? 615 HOH A O   1 
HETATM 5681 O O   . HOH C 2 .   ? -35.93881  -11.10040 -93.63971  1.000 30.39797 ? 616 HOH A O   1 
HETATM 5682 O O   . HOH C 2 .   ? -19.52981  -14.98618 -123.13658 1.000 49.23771 ? 617 HOH A O   1 
HETATM 5683 O O   . HOH C 2 .   ? -28.81193  -43.98826 -113.91810 1.000 35.73614 ? 618 HOH A O   1 
HETATM 5684 O O   . HOH C 2 .   ? -38.122    -45.593   -114.646   1.000 47.08000 ? 619 HOH A O   1 
HETATM 5685 O O   . HOH C 2 .   ? -44.36631  5.83375   -95.58319  1.000 52.01249 ? 620 HOH A O   1 
HETATM 5686 O O   . HOH C 2 .   ? -31.41201  -25.85648 -134.04657 1.000 52.16758 ? 621 HOH A O   1 
HETATM 5687 O O   . HOH C 2 .   ? -48.13034  -19.23182 -129.45072 1.000 36.33955 ? 622 HOH A O   1 
HETATM 5688 O O   . HOH C 2 .   ? -28.07541  -24.39286 -128.76921 1.000 49.75030 ? 623 HOH A O   1 
HETATM 5689 O O   . HOH C 2 .   ? -35.71401  -5.63092  -119.67347 1.000 50.20012 ? 624 HOH A O   1 
HETATM 5690 O O   . HOH C 2 .   ? -34.76155  -1.15013  -93.06441  1.000 46.22652 ? 625 HOH A O   1 
HETATM 5691 O O   . HOH C 2 .   ? -5.59527   -24.99948 -108.62070 1.000 60.90652 ? 626 HOH A O   1 
HETATM 5692 O O   . HOH C 2 .   ? -7.30913   -15.39277 -118.20222 1.000 49.64526 ? 627 HOH A O   1 
HETATM 5693 O O   . HOH C 2 .   ? -24.50812  -24.49336 -130.26165 1.000 51.28240 ? 628 HOH A O   1 
HETATM 5694 O O   . HOH C 2 .   ? -27.99613  -16.92839 -98.66560  1.000 38.35941 ? 629 HOH A O   1 
HETATM 5695 O O   . HOH C 2 .   ? -53.85188  -32.31904 -96.31747  1.000 52.46652 ? 630 HOH A O   1 
HETATM 5696 O O   . HOH C 2 .   ? -7.17293   -16.72083 -119.96295 1.000 44.15867 ? 631 HOH A O   1 
HETATM 5697 O O   . HOH C 2 .   ? -60.19930  -26.63873 -101.21102 1.000 42.26443 ? 632 HOH A O   1 
HETATM 5698 O O   . HOH C 2 .   ? -34.16965  2.67567   -111.89034 1.000 48.60652 ? 633 HOH A O   1 
HETATM 5699 O O   . HOH C 2 .   ? -8.72854   -21.69272 -108.09129 1.000 46.07479 ? 634 HOH A O   1 
HETATM 5700 O O   . HOH C 2 .   ? -36.32078  -14.97332 -132.31179 1.000 46.42494 ? 635 HOH A O   1 
HETATM 5701 O O   . HOH C 2 .   ? -19.05035  -38.08942 -109.82083 1.000 44.24063 ? 636 HOH A O   1 
HETATM 5702 O O   . HOH C 2 .   ? -60.41029  -21.62907 -115.97019 1.000 38.32581 ? 637 HOH A O   1 
HETATM 5703 O O   . HOH C 2 .   ? -43.58447  -35.30164 -108.26328 1.000 36.17434 ? 638 HOH A O   1 
HETATM 5704 O O   . HOH C 2 .   ? -25.756    -40.868   -103.620   1.000 43.19831 ? 639 HOH A O   1 
HETATM 5705 O O   . HOH C 2 .   ? -38.23604  -3.62502  -109.33548 1.000 34.80434 ? 640 HOH A O   1 
HETATM 5706 O O   . HOH C 2 .   ? -45.36926  -16.20368 -133.86172 1.000 51.55234 ? 641 HOH A O   1 
HETATM 5707 O O   . HOH C 2 .   ? -38.40491  -3.93577  -116.63519 1.000 36.89736 ? 642 HOH A O   1 
HETATM 5708 O O   . HOH C 2 .   ? -29.58070  -28.38530 -91.27127  1.000 43.24472 ? 643 HOH A O   1 
HETATM 5709 O O   . HOH C 2 .   ? -29.80348  -8.73292  -103.18586 1.000 43.53612 ? 644 HOH A O   1 
HETATM 5710 O O   . HOH C 2 .   ? -38.12803  -18.96216 -85.92576  1.000 49.21110 ? 645 HOH A O   1 
HETATM 5711 O O   . HOH C 2 .   ? -34.89252  -13.78761 -131.03527 1.000 39.08783 ? 646 HOH A O   1 
HETATM 5712 O O   . HOH C 2 .   ? -47.31900  -14.41257 -129.49715 1.000 42.32277 ? 647 HOH A O   1 
HETATM 5713 O O   . HOH C 2 .   ? -7.825     -29.824   -111.572   1.000 38.71579 ? 648 HOH A O   1 
HETATM 5714 O O   . HOH C 2 .   ? -32.76739  -3.04153  -93.68223  1.000 37.98259 ? 649 HOH A O   1 
HETATM 5715 O O   . HOH C 2 .   ? -50.35031  -0.14732  -109.91887 1.000 26.95677 ? 650 HOH A O   1 
HETATM 5716 O O   . HOH C 2 .   ? -32.23615  -13.69639 -94.87849  1.000 40.65208 ? 651 HOH A O   1 
HETATM 5717 O O   . HOH C 2 .   ? -18.79749  -36.71070 -121.35961 1.000 50.81317 ? 652 HOH A O   1 
HETATM 5718 O O   . HOH C 2 .   ? -38.60596  -38.52478 -110.09691 1.000 39.96652 ? 653 HOH A O   1 
HETATM 5719 O O   . HOH C 2 .   ? -49.17730  -19.78760 -89.51792  1.000 42.05742 ? 654 HOH A O   1 
HETATM 5720 O O   . HOH C 2 .   ? -31.85571  -14.92455 -97.74540  1.000 35.18740 ? 655 HOH A O   1 
HETATM 5721 O O   . HOH C 2 .   ? -60.77742  -25.69906 -114.20244 1.000 37.94800 ? 656 HOH A O   1 
HETATM 5722 O O   . HOH C 2 .   ? -17.95761  -23.16914 -96.98648  1.000 56.15652 ? 657 HOH A O   1 
HETATM 5723 O O   . HOH C 2 .   ? -31.056    -38.061   -91.985    1.000 46.20868 ? 658 HOH A O   1 
HETATM 5724 O O   . HOH C 2 .   ? -39.62528  -7.31584  -108.85853 1.000 23.18123 ? 659 HOH A O   1 
HETATM 5725 O O   . HOH C 2 .   ? -41.00174  -5.34208  -113.67665 1.000 28.65685 ? 660 HOH A O   1 
HETATM 5726 O O   . HOH C 2 .   ? -35.83154  4.29327   -113.87855 1.000 49.05908 ? 661 HOH A O   1 
HETATM 5727 O O   . HOH C 2 .   ? -2.80784   -25.84728 -114.54232 1.000 50.76899 ? 662 HOH A O   1 
HETATM 5728 O O   . HOH C 2 .   ? -34.29230  -11.51322 -111.77673 1.000 30.05661 ? 663 HOH A O   1 
HETATM 5729 O O   . HOH C 2 .   ? -26.278    -40.381   -101.537   1.000 38.71652 ? 664 HOH A O   1 
HETATM 5730 O O   . HOH C 2 .   ? -8.03525   -21.79635 -123.42333 1.000 46.89268 ? 665 HOH A O   1 
HETATM 5731 O O   . HOH C 2 .   ? -27.29666  -21.36667 -128.89037 1.000 46.61780 ? 666 HOH A O   1 
HETATM 5732 O O   . HOH C 2 .   ? -47.88521  -32.60324 -93.06756  1.000 47.28925 ? 667 HOH A O   1 
HETATM 5733 O O   . HOH C 2 .   ? -41.82055  -36.84535 -113.30832 1.000 38.37906 ? 668 HOH A O   1 
HETATM 5734 O O   . HOH C 2 .   ? -22.12432  -39.37147 -106.63084 1.000 23.71438 ? 669 HOH A O   1 
HETATM 5735 O O   . HOH C 2 .   ? -35.76527  2.16063   -93.48805  1.000 58.88060 ? 670 HOH A O   1 
HETATM 5736 O O   . HOH C 2 .   ? -40.092    -37.416   -120.805   1.000 38.36480 ? 671 HOH A O   1 
HETATM 5737 O O   . HOH C 2 .   ? -32.19346  -10.42716 -111.14322 1.000 38.83969 ? 672 HOH A O   1 
HETATM 5738 O O   . HOH C 2 .   ? -36.49387  -5.43310  -110.13819 1.000 33.21050 ? 673 HOH A O   1 
HETATM 5739 O O   . HOH C 2 .   ? -36.24558  -9.38238  -111.62510 1.000 24.69671 ? 674 HOH A O   1 
HETATM 5740 O O   . HOH C 2 .   ? -54.71790  -34.65891 -96.24766  1.000 44.22128 ? 675 HOH A O   1 
HETATM 5741 O O   . HOH C 2 .   ? -39.87076  -1.95752  -92.68644  1.000 50.34971 ? 676 HOH A O   1 
HETATM 5742 O O   . HOH C 2 .   ? -41.69051  -36.11528 -106.15764 1.000 28.65427 ? 677 HOH A O   1 
HETATM 5743 O O   . HOH C 2 .   ? -61.43291  -21.21543 -118.87844 1.000 34.45854 ? 678 HOH A O   1 
HETATM 5744 O O   . HOH C 2 .   ? -37.13764  -18.84490 -133.63992 1.000 39.48427 ? 679 HOH A O   1 
HETATM 5745 O O   . HOH C 2 .   ? -48.49866  2.29068   -106.71960 1.000 36.27564 ? 680 HOH A O   1 
HETATM 5746 O O   . HOH C 2 .   ? -42.30186  -34.38339 -119.82238 1.000 39.80506 ? 681 HOH A O   1 
HETATM 5747 O O   . HOH C 2 .   ? -50.03441  -6.08818  -95.74488  1.000 34.52733 ? 682 HOH A O   1 
HETATM 5748 O O   . HOH C 2 .   ? -10.68732  -22.68491 -104.14807 1.000 39.88145 ? 683 HOH A O   1 
HETATM 5749 O O   . HOH C 2 .   ? -24.97362  -23.01631 -133.02044 1.000 51.85127 ? 684 HOH A O   1 
HETATM 5750 O O   . HOH C 2 .   ? -30.92976  -11.98172 -103.50400 1.000 43.30129 ? 685 HOH A O   1 
HETATM 5751 O O   . HOH C 2 .   ? -36.72384  -8.22539  -109.38653 1.000 26.66491 ? 686 HOH A O   1 
HETATM 5752 O O   . HOH C 2 .   ? -53.85165  -5.31584  -91.93219  1.000 48.44746 ? 687 HOH A O   1 
HETATM 5753 O O   . HOH C 2 .   ? -44.54064  -13.75966 -135.22858 1.000 55.97378 ? 688 HOH A O   1 
HETATM 5754 O O   . HOH C 2 .   ? -44.99987  -32.97745 -115.72479 1.000 39.80131 ? 689 HOH A O   1 
HETATM 5755 O O   . HOH C 2 .   ? -4.93307   -27.96411 -108.61490 1.000 45.87889 ? 690 HOH A O   1 
HETATM 5756 O O   . HOH C 2 .   ? -29.67396  -10.22747 -105.04171 1.000 40.13404 ? 691 HOH A O   1 
HETATM 5757 O O   . HOH C 2 .   ? -35.46715  1.11910   -117.99584 1.000 44.64198 ? 692 HOH A O   1 
HETATM 5758 O O   . HOH C 2 .   ? -65.25643  -16.01868 -115.95632 1.000 50.10989 ? 693 HOH A O   1 
HETATM 5759 O O   . HOH D 2 .   ? -106.90788 10.44331  -90.56095  1.000 49.61652 ? 401 HOH B O   1 
HETATM 5760 O O   . HOH D 2 .   ? -93.03855  3.20746   -109.81174 1.000 44.15212 ? 402 HOH B O   1 
HETATM 5761 O O   . HOH D 2 .   ? -82.96932  -21.15457 -109.74711 1.000 35.99030 ? 403 HOH B O   1 
HETATM 5762 O O   . HOH D 2 .   ? -69.81870  -1.19868  -106.91613 1.000 32.25572 ? 404 HOH B O   1 
HETATM 5763 O O   . HOH D 2 .   ? -81.06075  -5.17860  -77.55230  1.000 35.27986 ? 405 HOH B O   1 
HETATM 5764 O O   . HOH D 2 .   ? -74.39171  0.88525   -87.47266  1.000 33.24810 ? 406 HOH B O   1 
HETATM 5765 O O   . HOH D 2 .   ? -78.72232  -13.69017 -74.44762  1.000 48.95749 ? 407 HOH B O   1 
HETATM 5766 O O   . HOH D 2 .   ? -91.43881  -34.09066 -97.64709  1.000 44.17998 ? 408 HOH B O   1 
HETATM 5767 O O   . HOH D 2 .   ? -84.02305  -7.78110  -114.01498 1.000 45.58899 ? 409 HOH B O   1 
HETATM 5768 O O   . HOH D 2 .   ? -79.97353  -19.87115 -117.19725 1.000 44.02763 ? 410 HOH B O   1 
HETATM 5769 O O   . HOH D 2 .   ? -69.69074  -4.89282  -81.61073  1.000 26.95060 ? 411 HOH B O   1 
HETATM 5770 O O   . HOH D 2 .   ? -68.71589  -19.00787 -109.13168 1.000 42.34726 ? 412 HOH B O   1 
HETATM 5771 O O   . HOH D 2 .   ? -87.06627  -11.11640 -89.55181  1.000 36.49151 ? 413 HOH B O   1 
HETATM 5772 O O   . HOH D 2 .   ? -79.64144  -5.16297  -112.93249 1.000 31.12458 ? 414 HOH B O   1 
HETATM 5773 O O   . HOH D 2 .   ? -117.54886 -13.74233 -92.85725  1.000 42.35628 ? 415 HOH B O   1 
HETATM 5774 O O   . HOH D 2 .   ? -98.31425  -0.86314  -111.63085 1.000 37.64518 ? 416 HOH B O   1 
HETATM 5775 O O   . HOH D 2 .   ? -84.31016  -28.26513 -91.18380  1.000 36.95783 ? 417 HOH B O   1 
HETATM 5776 O O   . HOH D 2 .   ? -85.16064  -13.33132 -102.75749 1.000 23.46676 ? 418 HOH B O   1 
HETATM 5777 O O   . HOH D 2 .   ? -97.39152  -7.83074  -111.78641 1.000 41.70987 ? 419 HOH B O   1 
HETATM 5778 O O   . HOH D 2 .   ? -86.01425  -11.60669 -106.49786 1.000 22.68413 ? 420 HOH B O   1 
HETATM 5779 O O   . HOH D 2 .   ? -83.79423  -17.70343 -90.52422  1.000 25.56831 ? 421 HOH B O   1 
HETATM 5780 O O   . HOH D 2 .   ? -78.46427  -25.71723 -85.58697  1.000 38.04183 ? 422 HOH B O   1 
HETATM 5781 O O   . HOH D 2 .   ? -91.18404  -3.05206  -96.42327  1.000 17.71514 ? 423 HOH B O   1 
HETATM 5782 O O   . HOH D 2 .   ? -76.70702  -2.59940  -96.37783  1.000 19.05842 ? 424 HOH B O   1 
HETATM 5783 O O   . HOH D 2 .   ? -71.16342  -15.78963 -80.54538  1.000 30.01742 ? 425 HOH B O   1 
HETATM 5784 O O   . HOH D 2 .   ? -110.34459 3.93916   -88.94276  1.000 33.19099 ? 426 HOH B O   1 
HETATM 5785 O O   . HOH D 2 .   ? -69.10766  -3.42073  -73.59026  1.000 33.25353 ? 427 HOH B O   1 
HETATM 5786 O O   . HOH D 2 .   ? -66.99753  -1.85072  -87.54375  1.000 35.03893 ? 428 HOH B O   1 
HETATM 5787 O O   . HOH D 2 .   ? -92.59620  -16.69107 -87.18611  1.000 28.64141 ? 429 HOH B O   1 
HETATM 5788 O O   . HOH D 2 .   ? -97.79659  -7.84020  -107.93499 1.000 27.87699 ? 430 HOH B O   1 
HETATM 5789 O O   . HOH D 2 .   ? -90.82502  -4.63488  -100.76574 1.000 18.47716 ? 431 HOH B O   1 
HETATM 5790 O O   . HOH D 2 .   ? -70.70121  -2.57481  -78.85482  1.000 40.82120 ? 432 HOH B O   1 
HETATM 5791 O O   . HOH D 2 .   ? -97.89915  -12.80606 -88.29671  1.000 24.48673 ? 433 HOH B O   1 
HETATM 5792 O O   . HOH D 2 .   ? -103.31537 5.43057   -87.28383  1.000 34.16468 ? 434 HOH B O   1 
HETATM 5793 O O   . HOH D 2 .   ? -66.81370  -3.07696  -104.26066 1.000 34.20922 ? 435 HOH B O   1 
HETATM 5794 O O   . HOH D 2 .   ? -84.81254  -4.34912  -90.83917  1.000 32.57510 ? 436 HOH B O   1 
HETATM 5795 O O   . HOH D 2 .   ? -71.70642  -19.06262 -109.99703 1.000 44.14138 ? 437 HOH B O   1 
HETATM 5796 O O   . HOH D 2 .   ? -87.72775  0.48488   -96.92046  1.000 22.55782 ? 438 HOH B O   1 
HETATM 5797 O O   . HOH D 2 .   ? -88.44106  -2.55854  -88.73573  1.000 35.64303 ? 439 HOH B O   1 
HETATM 5798 O O   . HOH D 2 .   ? -77.06375  -18.67162 -82.53810  1.000 45.73979 ? 440 HOH B O   1 
HETATM 5799 O O   . HOH D 2 .   ? -100.49868 -16.43767 -86.45257  1.000 30.17058 ? 441 HOH B O   1 
HETATM 5800 O O   . HOH D 2 .   ? -75.29675  -6.83559  -73.64920  1.000 35.30148 ? 442 HOH B O   1 
HETATM 5801 O O   . HOH D 2 .   ? -74.98422  -10.32822 -70.61554  1.000 42.47072 ? 443 HOH B O   1 
HETATM 5802 O O   . HOH D 2 .   ? -104.49375 -12.29408 -80.24786  1.000 40.56531 ? 444 HOH B O   1 
HETATM 5803 O O   . HOH D 2 .   ? -82.61452  -3.46213  -86.16281  1.000 34.01219 ? 445 HOH B O   1 
HETATM 5804 O O   . HOH D 2 .   ? -107.61781 -0.96321  -95.36968  1.000 21.70501 ? 446 HOH B O   1 
HETATM 5805 O O   . HOH D 2 .   ? -78.23471  -7.64480  -92.50040  1.000 18.85891 ? 447 HOH B O   1 
HETATM 5806 O O   . HOH D 2 .   ? -78.39337  -12.89583 -89.06975  1.000 28.71030 ? 448 HOH B O   1 
HETATM 5807 O O   . HOH D 2 .   ? -78.86192  -13.48881 -111.05683 1.000 30.99557 ? 449 HOH B O   1 
HETATM 5808 O O   . HOH D 2 .   ? -68.49463  3.71192   -97.15715  1.000 36.60289 ? 450 HOH B O   1 
HETATM 5809 O O   . HOH D 2 .   ? -110.22293 0.50658   -95.10801  1.000 26.96634 ? 451 HOH B O   1 
HETATM 5810 O O   . HOH D 2 .   ? -101.30922 -8.87558  -83.87180  1.000 27.97604 ? 452 HOH B O   1 
HETATM 5811 O O   . HOH D 2 .   ? -87.75588  -32.39136 -102.12894 1.000 41.29244 ? 453 HOH B O   1 
HETATM 5812 O O   . HOH D 2 .   ? -105.51463 -19.50600 -93.10132  1.000 35.12384 ? 454 HOH B O   1 
HETATM 5813 O O   . HOH D 2 .   ? -74.86834  -18.81180 -112.94655 1.000 46.83742 ? 455 HOH B O   1 
HETATM 5814 O O   . HOH D 2 .   ? -103.92490 1.15766   -106.29878 1.000 24.47950 ? 456 HOH B O   1 
HETATM 5815 O O   . HOH D 2 .   ? -91.99488  9.32190   -104.26634 1.000 33.44296 ? 457 HOH B O   1 
HETATM 5816 O O   . HOH D 2 .   ? -69.80913  -18.45601 -83.67241  1.000 39.31847 ? 458 HOH B O   1 
HETATM 5817 O O   . HOH D 2 .   ? -101.38989 -13.88562 -107.51201 1.000 42.71652 ? 459 HOH B O   1 
HETATM 5818 O O   . HOH D 2 .   ? -76.81938  -0.21042  -89.42561  1.000 29.27199 ? 460 HOH B O   1 
HETATM 5819 O O   . HOH D 2 .   ? -100.88630 -6.76235  -85.19445  1.000 30.60659 ? 461 HOH B O   1 
HETATM 5820 O O   . HOH D 2 .   ? -62.12710  -19.19936 -94.60027  1.000 39.64901 ? 462 HOH B O   1 
HETATM 5821 O O   . HOH D 2 .   ? -73.94777  -8.63071  -99.10717  1.000 28.85276 ? 463 HOH B O   1 
HETATM 5822 O O   . HOH D 2 .   ? -87.47604  -15.29153 -109.05166 1.000 36.26517 ? 464 HOH B O   1 
HETATM 5823 O O   . HOH D 2 .   ? -91.35514  -12.75520 -83.57211  1.000 35.05127 ? 465 HOH B O   1 
HETATM 5824 O O   . HOH D 2 .   ? -88.63273  -10.43815 -97.70289  1.000 18.55900 ? 466 HOH B O   1 
HETATM 5825 O O   . HOH D 2 .   ? -89.25569  -7.22815  -91.99884  1.000 24.29198 ? 467 HOH B O   1 
HETATM 5826 O O   . HOH D 2 .   ? -100.41088 -13.84801 -87.38434  1.000 23.98233 ? 468 HOH B O   1 
HETATM 5827 O O   . HOH D 2 .   ? -113.59100 3.03882   -89.82140  1.000 36.44904 ? 469 HOH B O   1 
HETATM 5828 O O   . HOH D 2 .   ? -81.57881  -0.93922  -96.42318  1.000 32.52588 ? 470 HOH B O   1 
HETATM 5829 O O   . HOH D 2 .   ? -90.59383  -7.35722  -110.16185 1.000 26.69263 ? 471 HOH B O   1 
HETATM 5830 O O   . HOH D 2 .   ? -75.21360  -30.34645 -96.63815  1.000 59.77652 ? 472 HOH B O   1 
HETATM 5831 O O   . HOH D 2 .   ? -113.91970 -11.68117 -83.99148  1.000 36.41435 ? 473 HOH B O   1 
HETATM 5832 O O   . HOH D 2 .   ? -89.84374  -9.98917  -91.67366  1.000 28.38799 ? 474 HOH B O   1 
HETATM 5833 O O   . HOH D 2 .   ? -113.62401 0.10766   -92.16488  1.000 33.29860 ? 475 HOH B O   1 
HETATM 5834 O O   . HOH D 2 .   ? -97.99318  -5.47415  -106.83461 1.000 20.76610 ? 476 HOH B O   1 
HETATM 5835 O O   . HOH D 2 .   ? -86.88630  -10.21812 -99.74277  1.000 18.62096 ? 477 HOH B O   1 
HETATM 5836 O O   . HOH D 2 .   ? -85.03215  -8.24924  -103.51018 1.000 25.85995 ? 478 HOH B O   1 
HETATM 5837 O O   . HOH D 2 .   ? -79.16287  -1.86294  -97.40995  1.000 30.47086 ? 479 HOH B O   1 
HETATM 5838 O O   . HOH D 2 .   ? -71.72256  4.38037   -95.50445  1.000 33.37947 ? 480 HOH B O   1 
HETATM 5839 O O   . HOH D 2 .   ? -69.06907  -25.20370 -105.48009 1.000 41.78767 ? 481 HOH B O   1 
HETATM 5840 O O   . HOH D 2 .   ? -86.26631  8.22223   -96.72167  1.000 44.85468 ? 482 HOH B O   1 
HETATM 5841 O O   . HOH D 2 .   ? -76.90065  2.43578   -90.22418  1.000 42.04159 ? 483 HOH B O   1 
HETATM 5842 O O   . HOH D 2 .   ? -94.67524  9.28176   -105.20339 1.000 26.75195 ? 484 HOH B O   1 
HETATM 5843 O O   . HOH D 2 .   ? -63.53113  -14.62350 -82.60302  1.000 28.36352 ? 485 HOH B O   1 
HETATM 5844 O O   . HOH D 2 .   ? -94.76735  -12.62008 -111.26034 1.000 29.52223 ? 486 HOH B O   1 
HETATM 5845 O O   . HOH D 2 .   ? -76.82109  -11.73683 -83.65945  1.000 31.83252 ? 487 HOH B O   1 
HETATM 5846 O O   . HOH D 2 .   ? -96.76182  -4.57340  -91.85126  1.000 37.10842 ? 488 HOH B O   1 
HETATM 5847 O O   . HOH D 2 .   ? -98.49921  -3.52420  -96.40227  1.000 21.78178 ? 489 HOH B O   1 
HETATM 5848 O O   . HOH D 2 .   ? -66.94612  -5.37034  -92.55315  1.000 32.68629 ? 490 HOH B O   1 
HETATM 5849 O O   . HOH D 2 .   ? -77.09285  -6.42451  -82.08417  1.000 24.02994 ? 491 HOH B O   1 
HETATM 5850 O O   . HOH D 2 .   ? -108.52903 -1.14587  -105.59957 1.000 41.18401 ? 492 HOH B O   1 
HETATM 5851 O O   . HOH D 2 .   ? -99.50605  -6.31513  -91.83643  1.000 24.87375 ? 493 HOH B O   1 
HETATM 5852 O O   . HOH D 2 .   ? -82.11763  -1.31812  -90.48464  1.000 25.81228 ? 494 HOH B O   1 
HETATM 5853 O O   . HOH D 2 .   ? -87.32938  -14.15643 -111.44211 1.000 45.52844 ? 495 HOH B O   1 
HETATM 5854 O O   . HOH D 2 .   ? -91.44523  -23.44755 -83.44445  1.000 46.87444 ? 496 HOH B O   1 
HETATM 5855 O O   . HOH D 2 .   ? -68.78194  -15.41804 -82.72279  1.000 37.57773 ? 497 HOH B O   1 
HETATM 5856 O O   . HOH D 2 .   ? -113.67482 -9.32854  -82.69808  1.000 27.34827 ? 498 HOH B O   1 
HETATM 5857 O O   . HOH D 2 .   ? -77.51068  -2.03102  -75.75488  1.000 34.70591 ? 499 HOH B O   1 
HETATM 5858 O O   . HOH D 2 .   ? -80.79714  -4.60887  -92.61845  1.000 22.81063 ? 500 HOH B O   1 
HETATM 5859 O O   . HOH D 2 .   ? -93.94211  4.10659   -98.82142  1.000 28.41770 ? 501 HOH B O   1 
HETATM 5860 O O   . HOH D 2 .   ? -95.56062  4.17211   -108.38093 1.000 32.17940 ? 502 HOH B O   1 
HETATM 5861 O O   . HOH D 2 .   ? -76.54034  -9.20687  -84.01537  1.000 23.23057 ? 503 HOH B O   1 
HETATM 5862 O O   . HOH D 2 .   ? -72.76509  -27.01233 -90.96609  1.000 47.90569 ? 504 HOH B O   1 
HETATM 5863 O O   . HOH D 2 .   ? -71.68020  -24.09713 -92.30537  1.000 37.83021 ? 505 HOH B O   1 
HETATM 5864 O O   . HOH D 2 .   ? -62.25734  -1.32477  -96.48504  1.000 39.90096 ? 506 HOH B O   1 
HETATM 5865 O O   . HOH D 2 .   ? -108.67960 1.95225   -102.21509 1.000 24.87937 ? 507 HOH B O   1 
HETATM 5866 O O   . HOH D 2 .   ? -93.15164  -29.25141 -85.19400  1.000 42.33178 ? 508 HOH B O   1 
HETATM 5867 O O   . HOH D 2 .   ? -66.44313  -2.62979  -92.28856  1.000 30.29590 ? 509 HOH B O   1 
HETATM 5868 O O   . HOH D 2 .   ? -82.34614  -19.10474 -88.32342  1.000 28.34939 ? 510 HOH B O   1 
HETATM 5869 O O   . HOH D 2 .   ? -116.92105 -3.70778  -83.06880  1.000 46.85615 ? 511 HOH B O   1 
HETATM 5870 O O   . HOH D 2 .   ? -70.44188  2.61775   -90.96142  1.000 34.72331 ? 512 HOH B O   1 
HETATM 5871 O O   . HOH D 2 .   ? -74.11369  -30.04697 -91.50785  1.000 45.23166 ? 513 HOH B O   1 
HETATM 5872 O O   . HOH D 2 .   ? -72.11136  -26.62564 -99.17039  1.000 34.89742 ? 514 HOH B O   1 
HETATM 5873 O O   . HOH D 2 .   ? -83.22063  -21.50456 -89.55859  1.000 35.77173 ? 515 HOH B O   1 
HETATM 5874 O O   . HOH D 2 .   ? -85.94178  -1.89219  -89.49243  1.000 48.71652 ? 516 HOH B O   1 
HETATM 5875 O O   . HOH D 2 .   ? -107.80361 5.25834   -89.12801  1.000 27.13663 ? 517 HOH B O   1 
HETATM 5876 O O   . HOH D 2 .   ? -79.77817  -32.96828 -94.76195  1.000 45.03366 ? 518 HOH B O   1 
HETATM 5877 O O   . HOH D 2 .   ? -108.26373 -7.78756  -103.96631 1.000 39.16967 ? 519 HOH B O   1 
HETATM 5878 O O   . HOH D 2 .   ? -116.45682 -11.39395 -85.43870  1.000 41.52389 ? 520 HOH B O   1 
HETATM 5879 O O   . HOH D 2 .   ? -72.32732  -16.29847 -85.23652  1.000 35.48881 ? 521 HOH B O   1 
HETATM 5880 O O   . HOH D 2 .   ? -65.97455  -12.51171 -94.39771  1.000 24.84951 ? 522 HOH B O   1 
HETATM 5881 O O   . HOH D 2 .   ? -115.90987 -15.37342 -95.05441  1.000 40.54655 ? 523 HOH B O   1 
HETATM 5882 O O   . HOH D 2 .   ? -69.37738  -10.27065 -113.65676 1.000 42.18976 ? 524 HOH B O   1 
HETATM 5883 O O   . HOH D 2 .   ? -110.18407 2.60631   -86.48556  1.000 36.57406 ? 525 HOH B O   1 
HETATM 5884 O O   . HOH D 2 .   ? -77.40621  -15.04754 -84.53869  1.000 38.66823 ? 526 HOH B O   1 
HETATM 5885 O O   . HOH D 2 .   ? -79.28556  -28.22358 -111.14208 1.000 46.88727 ? 527 HOH B O   1 
HETATM 5886 O O   . HOH D 2 .   ? -91.84580  -10.62428 -84.97000  1.000 34.29924 ? 528 HOH B O   1 
HETATM 5887 O O   . HOH D 2 .   ? -81.13301  -0.97471  -87.03256  1.000 38.77439 ? 529 HOH B O   1 
HETATM 5888 O O   . HOH D 2 .   ? -69.39328  -6.71991  -79.54602  1.000 31.16361 ? 530 HOH B O   1 
HETATM 5889 O O   . HOH D 2 .   ? -68.49240  -3.45308  -106.37293 1.000 32.11229 ? 531 HOH B O   1 
HETATM 5890 O O   . HOH D 2 .   ? -62.94903  -4.18354  -93.76174  1.000 29.09691 ? 532 HOH B O   1 
HETATM 5891 O O   . HOH D 2 .   ? -76.67297  -12.06533 -81.03469  1.000 38.85894 ? 533 HOH B O   1 
HETATM 5892 O O   . HOH D 2 .   ? -97.37356  -22.81593 -79.62418  1.000 53.42244 ? 534 HOH B O   1 
HETATM 5893 O O   . HOH D 2 .   ? -80.92408  6.64245   -109.35172 1.000 50.04921 ? 535 HOH B O   1 
HETATM 5894 O O   . HOH D 2 .   ? -69.01254  -5.31152  -110.49708 1.000 36.29612 ? 536 HOH B O   1 
HETATM 5895 O O   . HOH D 2 .   ? -90.62491  -27.42210 -105.98757 1.000 45.20669 ? 537 HOH B O   1 
HETATM 5896 O O   . HOH D 2 .   ? -76.32665  -27.46273 -109.43765 1.000 46.49471 ? 538 HOH B O   1 
HETATM 5897 O O   . HOH D 2 .   ? -96.59171  -25.64178 -108.43128 1.000 48.09591 ? 539 HOH B O   1 
HETATM 5898 O O   . HOH D 2 .   ? -63.63715  -2.11644  -92.40016  1.000 41.29044 ? 540 HOH B O   1 
HETATM 5899 O O   . HOH D 2 .   ? -93.44082  6.52452   -93.17190  1.000 35.65027 ? 541 HOH B O   1 
HETATM 5900 O O   . HOH D 2 .   ? -64.61537  0.46741   -91.10278  1.000 38.02085 ? 542 HOH B O   1 
HETATM 5901 O O   . HOH D 2 .   ? -77.86312  -31.06305 -88.06964  1.000 41.72400 ? 543 HOH B O   1 
HETATM 5902 O O   . HOH D 2 .   ? -85.89674  -33.15348 -95.68512  1.000 47.97767 ? 544 HOH B O   1 
HETATM 5903 O O   . HOH D 2 .   ? -96.97214  4.92308   -89.42471  1.000 36.68135 ? 545 HOH B O   1 
HETATM 5904 O O   . HOH D 2 .   ? -85.04098  -23.34830 -112.69475 1.000 45.75323 ? 546 HOH B O   1 
HETATM 5905 O O   . HOH D 2 .   ? -63.74649  -22.16386 -108.49159 1.000 51.54842 ? 547 HOH B O   1 
HETATM 5906 O O   . HOH D 2 .   ? -61.97915  -7.66661  -82.28706  1.000 38.87652 ? 548 HOH B O   1 
HETATM 5907 O O   . HOH D 2 .   ? -64.47242  -0.68020  -105.04665 1.000 39.16263 ? 549 HOH B O   1 
HETATM 5908 O O   . HOH D 2 .   ? -119.47072 -3.06416  -95.44349  1.000 45.22815 ? 550 HOH B O   1 
HETATM 5909 O O   . HOH D 2 .   ? -102.42763 -19.25900 -109.25909 1.000 36.45920 ? 551 HOH B O   1 
HETATM 5910 O O   . HOH D 2 .   ? -103.54762 3.71358   -85.53439  1.000 34.01230 ? 552 HOH B O   1 
HETATM 5911 O O   . HOH D 2 .   ? -87.73728  -11.45684 -95.12394  1.000 30.38801 ? 553 HOH B O   1 
HETATM 5912 O O   . HOH D 2 .   ? -83.59031  7.85411   -102.98215 1.000 52.84850 ? 554 HOH B O   1 
HETATM 5913 O O   . HOH D 2 .   ? -71.71117  6.41413   -99.51417  1.000 38.88548 ? 555 HOH B O   1 
HETATM 5914 O O   . HOH D 2 .   ? -98.12737  -3.96740  -85.09211  1.000 34.11554 ? 556 HOH B O   1 
HETATM 5915 O O   . HOH D 2 .   ? -57.99128  -12.60078 -91.81609  1.000 36.09466 ? 557 HOH B O   1 
HETATM 5916 O O   . HOH D 2 .   ? -80.80536  -14.76944 -71.59501  1.000 43.95179 ? 558 HOH B O   1 
HETATM 5917 O O   . HOH D 2 .   ? -93.57379  5.54795   -95.96790  1.000 25.11024 ? 559 HOH B O   1 
HETATM 5918 O O   . HOH D 2 .   ? -102.90931 -22.04926 -80.86274  1.000 51.53394 ? 560 HOH B O   1 
HETATM 5919 O O   . HOH D 2 .   ? -97.21645  -32.93887 -99.86132  1.000 47.25427 ? 561 HOH B O   1 
HETATM 5920 O O   . HOH D 2 .   ? -81.89586  -21.75797 -112.06568 1.000 36.48668 ? 562 HOH B O   1 
HETATM 5921 O O   . HOH D 2 .   ? -59.57781  -14.25925 -84.03231  1.000 36.34661 ? 563 HOH B O   1 
HETATM 5922 O O   . HOH D 2 .   ? -116.99205 -4.16199  -85.94270  1.000 35.09876 ? 564 HOH B O   1 
HETATM 5923 O O   . HOH D 2 .   ? -72.18806  -25.51693 -88.48603  1.000 42.74150 ? 565 HOH B O   1 
HETATM 5924 O O   . HOH D 2 .   ? -83.66984  -32.59015 -89.65160  1.000 51.75599 ? 566 HOH B O   1 
HETATM 5925 O O   . HOH D 2 .   ? -86.01525  -27.30576 -83.64731  1.000 40.57916 ? 567 HOH B O   1 
HETATM 5926 O O   . HOH D 2 .   ? -65.85069  -21.52727 -109.82887 1.000 44.90936 ? 568 HOH B O   1 
HETATM 5927 O O   . HOH D 2 .   ? -102.20775 -23.09805 -83.84673  1.000 44.90497 ? 569 HOH B O   1 
HETATM 5928 O O   . HOH D 2 .   ? -76.10467  -7.58364  -115.77870 1.000 34.29537 ? 570 HOH B O   1 
HETATM 5929 O O   . HOH D 2 .   ? -68.30303  -22.23824 -111.09775 1.000 48.30398 ? 571 HOH B O   1 
HETATM 5930 O O   . HOH D 2 .   ? -89.63689  1.22973   -89.69415  1.000 26.02146 ? 572 HOH B O   1 
HETATM 5931 O O   . HOH D 2 .   ? -96.92961  11.46842  -96.05796  1.000 35.33252 ? 573 HOH B O   1 
HETATM 5932 O O   . HOH D 2 .   ? -62.43130  -4.98402  -80.41631  1.000 43.97868 ? 574 HOH B O   1 
HETATM 5933 O O   . HOH D 2 .   ? -103.483   12.776    -91.435    1.000 41.42635 ? 575 HOH B O   1 
HETATM 5934 O O   . HOH D 2 .   ? -78.06895  -2.45140  -112.97493 1.000 35.54210 ? 576 HOH B O   1 
HETATM 5935 O O   . HOH D 2 .   ? -89.34107  -16.95477 -108.92183 1.000 31.39792 ? 577 HOH B O   1 
HETATM 5936 O O   . HOH D 2 .   ? -79.86546  -18.62359 -86.84490  1.000 30.29984 ? 578 HOH B O   1 
HETATM 5937 O O   . HOH D 2 .   ? -85.85052  1.96133   -93.15147  1.000 35.16000 ? 579 HOH B O   1 
HETATM 5938 O O   . HOH D 2 .   ? -72.02299  2.45909   -103.49475 1.000 38.14174 ? 580 HOH B O   1 
HETATM 5939 O O   . HOH D 2 .   ? -81.45305  3.72959   -92.83397  1.000 36.04526 ? 581 HOH B O   1 
HETATM 5940 O O   . HOH D 2 .   ? -63.69763  -21.36796 -97.45945  1.000 40.35656 ? 582 HOH B O   1 
HETATM 5941 O O   . HOH D 2 .   ? -101.57591 -26.77445 -84.02823  1.000 48.01193 ? 583 HOH B O   1 
HETATM 5942 O O   . HOH D 2 .   ? -116.28537 -8.93385  -95.42915  1.000 46.74810 ? 584 HOH B O   1 
HETATM 5943 O O   . HOH D 2 .   ? -57.78242  -11.05950 -84.87717  1.000 43.12738 ? 585 HOH B O   1 
HETATM 5944 O O   . HOH D 2 .   ? -118.24423 -10.92240 -88.57085  1.000 38.65733 ? 586 HOH B O   1 
HETATM 5945 O O   . HOH D 2 .   ? -101.19642 -16.24218 -114.49176 1.000 40.81224 ? 587 HOH B O   1 
HETATM 5946 O O   . HOH D 2 .   ? -81.00074  -14.51083 -112.82936 1.000 36.12372 ? 588 HOH B O   1 
HETATM 5947 O O   . HOH D 2 .   ? -114.40973 -1.42560  -93.98497  1.000 34.63468 ? 589 HOH B O   1 
HETATM 5948 O O   . HOH D 2 .   ? -82.43675  -24.34480 -113.02129 1.000 44.67744 ? 590 HOH B O   1 
HETATM 5949 O O   . HOH D 2 .   ? -99.41298  5.00219   -88.12597  1.000 34.50651 ? 591 HOH B O   1 
HETATM 5950 O O   . HOH D 2 .   ? -79.85443  1.24768   -116.18318 1.000 34.66706 ? 592 HOH B O   1 
HETATM 5951 O O   . HOH D 2 .   ? -100.58451 2.87409   -84.23204  1.000 36.44195 ? 593 HOH B O   1 
HETATM 5952 O O   . HOH D 2 .   ? -86.54736  -8.19367  -90.86456  1.000 43.69472 ? 594 HOH B O   1 
HETATM 5953 O O   . HOH D 2 .   ? -80.12150  -9.94740  -114.78170 1.000 36.42391 ? 595 HOH B O   1 
HETATM 5954 O O   . HOH D 2 .   ? -113.02339 3.11151   -86.93452  1.000 49.19289 ? 596 HOH B O   1 
HETATM 5955 O O   . HOH D 2 .   ? -72.64137  4.88573   -104.16207 1.000 38.79715 ? 597 HOH B O   1 
HETATM 5956 O O   . HOH D 2 .   ? -108.858   -11.442   -110.822   1.000 33.57703 ? 598 HOH B O   1 
HETATM 5957 O O   . HOH D 2 .   ? -66.84458  -3.17942  -109.14652 1.000 52.30646 ? 599 HOH B O   1 
HETATM 5958 O O   . HOH D 2 .   ? -104.95989 -15.18807 -81.62467  1.000 26.71926 ? 600 HOH B O   1 
HETATM 5959 O O   . HOH D 2 .   ? -94.826    -20.354   -76.715    1.000 44.61922 ? 601 HOH B O   1 
HETATM 5960 O O   . HOH D 2 .   ? -79.85041  -0.12387  -89.37489  1.000 31.87515 ? 602 HOH B O   1 
HETATM 5961 O O   . HOH D 2 .   ? -61.54634  -24.45171 -102.69327 1.000 34.94233 ? 603 HOH B O   1 
HETATM 5962 O O   . HOH D 2 .   ? -65.72354  -24.01074 -108.91369 1.000 52.76925 ? 604 HOH B O   1 
HETATM 5963 O O   . HOH D 2 .   ? -114.45080 -9.07163  -98.01400  1.000 45.11639 ? 605 HOH B O   1 
HETATM 5964 O O   . HOH D 2 .   ? -93.405    -18.316   -78.530    1.000 35.80088 ? 606 HOH B O   1 
HETATM 5965 O O   . HOH D 2 .   ? -69.47823  0.27463   -105.01722 1.000 40.19652 ? 607 HOH B O   1 
HETATM 5966 O O   . HOH D 2 .   ? -89.207    -7.780    -86.615    1.000 42.07652 ? 608 HOH B O   1 
HETATM 5967 O O   . HOH D 2 .   ? -90.06485  -3.25362  -112.86456 1.000 49.51082 ? 609 HOH B O   1 
HETATM 5968 O O   . HOH D 2 .   ? -116.23817 -12.61700 -95.54524  1.000 40.25802 ? 610 HOH B O   1 
HETATM 5969 O O   . HOH D 2 .   ? -67.24365  -23.82289 -101.09183 1.000 40.37578 ? 611 HOH B O   1 
HETATM 5970 O O   . HOH D 2 .   ? -95.417    -16.986   -80.209    1.000 40.58663 ? 612 HOH B O   1 
HETATM 5971 O O   . HOH D 2 .   ? -89.59826  -11.46951 -112.87815 1.000 46.12241 ? 613 HOH B O   1 
HETATM 5972 O O   . HOH D 2 .   ? -107.513   -22.472   -107.771   1.000 57.50652 ? 614 HOH B O   1 
HETATM 5973 O O   . HOH D 2 .   ? -82.06327  -21.85700 -78.91794  0.50  60.41600 ? 615 HOH B O   1 
HETATM 5974 O O   . HOH D 2 .   ? -94.75801  4.18346   -87.48312  1.000 36.11861 ? 616 HOH B O   1 
HETATM 5975 O O   . HOH D 2 .   ? -98.23296  2.23531   -86.20363  1.000 39.06330 ? 617 HOH B O   1 
HETATM 5976 O O   . HOH D 2 .   ? -96.10766  6.53509   -109.75469 1.000 39.69477 ? 618 HOH B O   1 
HETATM 5977 O O   . HOH D 2 .   ? -67.10437  -14.73923 -80.31081  1.000 40.26989 ? 619 HOH B O   1 
HETATM 5978 O O   . HOH D 2 .   ? -88.18865  2.74830   -90.88099  1.000 43.02980 ? 620 HOH B O   1 
HETATM 5979 O O   . HOH D 2 .   ? -103.92788 -12.63515 -77.42425  1.000 37.70265 ? 621 HOH B O   1 
HETATM 5980 O O   . HOH D 2 .   ? -111.49680 -2.84060  -101.76666 1.000 42.81648 ? 622 HOH B O   1 
HETATM 5981 O O   . HOH D 2 .   ? -108.83380 3.91004   -84.22171  1.000 43.15888 ? 623 HOH B O   1 
HETATM 5982 O O   . HOH D 2 .   ? -60.98131  -15.24301 -81.68963  1.000 39.84996 ? 624 HOH B O   1 
HETATM 5983 O O   . HOH D 2 .   ? -101.429   3.540     -110.359   1.000 35.85121 ? 625 HOH B O   1 
HETATM 5984 O O   . HOH D 2 .   ? -68.86156  -12.50793 -113.71523 1.000 41.86551 ? 626 HOH B O   1 
HETATM 5985 O O   . HOH D 2 .   ? -78.26893  -0.12483  -114.85902 1.000 44.71704 ? 627 HOH B O   1 
HETATM 5986 O O   . HOH D 2 .   ? -75.34389  -3.14821  -74.04098  1.000 47.46789 ? 628 HOH B O   1 
HETATM 5987 O O   . HOH D 2 .   ? -79.18130  -13.00961 -86.07065  1.000 44.31182 ? 629 HOH B O   1 
HETATM 5988 O O   . HOH D 2 .   ? -60.37556  -4.33431  -93.98676  1.000 35.40356 ? 630 HOH B O   1 
HETATM 5989 O O   . HOH D 2 .   ? -85.67797  9.66670   -94.51051  1.000 45.16652 ? 631 HOH B O   1 
HETATM 5990 O O   . HOH D 2 .   ? -101.61956 -32.55991 -104.52462 1.000 42.59880 ? 632 HOH B O   1 
HETATM 5991 O O   . HOH D 2 .   ? -118.04545 0.09538   -92.50457  1.000 56.88862 ? 633 HOH B O   1 
HETATM 5992 O O   . HOH D 2 .   ? -59.65880  -10.37867 -91.09510  1.000 36.76615 ? 634 HOH B O   1 
HETATM 5993 O O   . HOH D 2 .   ? -62.99202  -7.97027  -94.32686  1.000 29.10927 ? 635 HOH B O   1 
HETATM 5994 O O   . HOH D 2 .   ? -116.87402 -1.53472  -86.62515  1.000 38.31897 ? 636 HOH B O   1 
HETATM 5995 O O   . HOH D 2 .   ? -62.90150  -5.07671  -90.17459  1.000 41.92652 ? 637 HOH B O   1 
HETATM 5996 O O   . HOH D 2 .   ? -117.56806 -13.66039 -86.76609  1.000 45.92039 ? 638 HOH B O   1 
HETATM 5997 O O   . HOH D 2 .   ? -67.29048  -25.14617 -103.77515 1.000 44.34652 ? 639 HOH B O   1 
HETATM 5998 O O   . HOH D 2 .   ? -55.65668  -18.75086 -86.50223  1.000 43.10800 ? 640 HOH B O   1 
HETATM 5999 O O   . HOH D 2 .   ? -67.49072  -19.34587 -85.24794  1.000 43.79652 ? 641 HOH B O   1 
HETATM 6000 O O   . HOH D 2 .   ? -64.24650  -6.27978  -92.56599  1.000 30.22817 ? 642 HOH B O   1 
HETATM 6001 O O   . HOH D 2 .   ? -84.77845  -3.84057  -87.88816  1.000 33.99905 ? 643 HOH B O   1 
HETATM 6002 O O   . HOH D 2 .   ? -89.98845  -8.61793  -112.71455 1.000 35.86867 ? 644 HOH B O   1 
HETATM 6003 O O   . HOH D 2 .   ? -106.40655 6.13840   -87.05807  1.000 31.22408 ? 645 HOH B O   1 
HETATM 6004 O O   . HOH D 2 .   ? -60.88672  0.25718   -98.42572  1.000 44.59410 ? 646 HOH B O   1 
HETATM 6005 O O   . HOH D 2 .   ? -91.82988  -13.15032 -113.67280 1.000 41.54743 ? 647 HOH B O   1 
HETATM 6006 O O   . HOH D 2 .   ? -86.39316  -1.28861  -85.58682  1.000 49.63379 ? 648 HOH B O   1 
# 
