data_9FK8
# 
_entry.id   9FK8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FK8         pdb_00009fk8 10.2210/pdb9fk8/pdb 
WWPDB D_1292139076 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FK8 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          Shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Chmelnik, O.' 2 ? 
'Dessau, M.'   3 ? 
'Shoham, Y.'   4 ? 
'Shoham, G.'   5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'The structure of XT6 from G.proteiniphilus T-6: The E265G/N158T mutant' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Chmelnik, O.' 2 ? 
primary 'Dessau, M.'   3 ? 
primary 'Shoham, Y.'   4 ? 
primary 'Shoham, G.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Endo-1,4-beta-xylanase 43787.582 1   3.2.1.8 ? ? ? 
2 non-polymer syn 'ZINC ION'             65.409    6   ?       ? ? ? 
3 non-polymer syn 'CHLORIDE ION'         35.453    2   ?       ? ? ? 
4 water       nat water                  18.015    504 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Xylanase,1,4-beta-D-xylan xylanohydrolase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVTEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVTEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'     ZN  
3 'CHLORIDE ION' CL  
4 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   ASN n 
1 3   ALA n 
1 4   ASP n 
1 5   SER n 
1 6   TYR n 
1 7   ALA n 
1 8   LYS n 
1 9   LYS n 
1 10  PRO n 
1 11  HIS n 
1 12  ILE n 
1 13  SER n 
1 14  ALA n 
1 15  LEU n 
1 16  ASN n 
1 17  ALA n 
1 18  PRO n 
1 19  GLN n 
1 20  LEU n 
1 21  ASP n 
1 22  GLN n 
1 23  ARG n 
1 24  TYR n 
1 25  LYS n 
1 26  ASN n 
1 27  GLU n 
1 28  PHE n 
1 29  THR n 
1 30  ILE n 
1 31  GLY n 
1 32  ALA n 
1 33  ALA n 
1 34  VAL n 
1 35  GLU n 
1 36  PRO n 
1 37  TYR n 
1 38  GLN n 
1 39  LEU n 
1 40  GLN n 
1 41  ASN n 
1 42  GLU n 
1 43  LYS n 
1 44  ASP n 
1 45  VAL n 
1 46  GLN n 
1 47  MET n 
1 48  LEU n 
1 49  LYS n 
1 50  ARG n 
1 51  HIS n 
1 52  PHE n 
1 53  ASN n 
1 54  SER n 
1 55  ILE n 
1 56  VAL n 
1 57  ALA n 
1 58  GLU n 
1 59  ASN n 
1 60  VAL n 
1 61  MET n 
1 62  LYS n 
1 63  PRO n 
1 64  ILE n 
1 65  SER n 
1 66  ILE n 
1 67  GLN n 
1 68  PRO n 
1 69  GLU n 
1 70  GLU n 
1 71  GLY n 
1 72  LYS n 
1 73  PHE n 
1 74  ASN n 
1 75  PHE n 
1 76  GLU n 
1 77  GLN n 
1 78  ALA n 
1 79  ASP n 
1 80  ARG n 
1 81  ILE n 
1 82  VAL n 
1 83  LYS n 
1 84  PHE n 
1 85  ALA n 
1 86  LYS n 
1 87  ALA n 
1 88  ASN n 
1 89  GLY n 
1 90  MET n 
1 91  ASP n 
1 92  ILE n 
1 93  ARG n 
1 94  PHE n 
1 95  HIS n 
1 96  THR n 
1 97  LEU n 
1 98  VAL n 
1 99  TRP n 
1 100 HIS n 
1 101 SER n 
1 102 GLN n 
1 103 VAL n 
1 104 PRO n 
1 105 GLN n 
1 106 TRP n 
1 107 PHE n 
1 108 PHE n 
1 109 LEU n 
1 110 ASP n 
1 111 LYS n 
1 112 GLU n 
1 113 GLY n 
1 114 LYS n 
1 115 PRO n 
1 116 MET n 
1 117 VAL n 
1 118 ASN n 
1 119 GLU n 
1 120 THR n 
1 121 ASP n 
1 122 PRO n 
1 123 VAL n 
1 124 LYS n 
1 125 ARG n 
1 126 GLU n 
1 127 GLN n 
1 128 ASN n 
1 129 LYS n 
1 130 GLN n 
1 131 LEU n 
1 132 LEU n 
1 133 LEU n 
1 134 LYS n 
1 135 ARG n 
1 136 LEU n 
1 137 GLU n 
1 138 THR n 
1 139 HIS n 
1 140 ILE n 
1 141 LYS n 
1 142 THR n 
1 143 ILE n 
1 144 VAL n 
1 145 GLU n 
1 146 ARG n 
1 147 TYR n 
1 148 LYS n 
1 149 ASP n 
1 150 ASP n 
1 151 ILE n 
1 152 LYS n 
1 153 TYR n 
1 154 TRP n 
1 155 ASP n 
1 156 VAL n 
1 157 VAL n 
1 158 THR n 
1 159 GLU n 
1 160 VAL n 
1 161 VAL n 
1 162 GLY n 
1 163 ASP n 
1 164 ASP n 
1 165 GLY n 
1 166 LYS n 
1 167 LEU n 
1 168 ARG n 
1 169 ASN n 
1 170 SER n 
1 171 PRO n 
1 172 TRP n 
1 173 TYR n 
1 174 GLN n 
1 175 ILE n 
1 176 ALA n 
1 177 GLY n 
1 178 ILE n 
1 179 ASP n 
1 180 TYR n 
1 181 ILE n 
1 182 LYS n 
1 183 VAL n 
1 184 ALA n 
1 185 PHE n 
1 186 GLN n 
1 187 ALA n 
1 188 ALA n 
1 189 ARG n 
1 190 LYS n 
1 191 TYR n 
1 192 GLY n 
1 193 GLY n 
1 194 ASP n 
1 195 ASN n 
1 196 ILE n 
1 197 LYS n 
1 198 LEU n 
1 199 TYR n 
1 200 MET n 
1 201 ASN n 
1 202 ASP n 
1 203 TYR n 
1 204 ASN n 
1 205 THR n 
1 206 GLU n 
1 207 VAL n 
1 208 GLU n 
1 209 PRO n 
1 210 LYS n 
1 211 ARG n 
1 212 THR n 
1 213 ALA n 
1 214 LEU n 
1 215 TYR n 
1 216 ASN n 
1 217 LEU n 
1 218 VAL n 
1 219 LYS n 
1 220 GLN n 
1 221 LEU n 
1 222 LYS n 
1 223 GLU n 
1 224 GLU n 
1 225 GLY n 
1 226 VAL n 
1 227 PRO n 
1 228 ILE n 
1 229 ASP n 
1 230 GLY n 
1 231 ILE n 
1 232 GLY n 
1 233 HIS n 
1 234 GLN n 
1 235 SER n 
1 236 HIS n 
1 237 ILE n 
1 238 GLN n 
1 239 ILE n 
1 240 GLY n 
1 241 TRP n 
1 242 PRO n 
1 243 SER n 
1 244 GLU n 
1 245 ALA n 
1 246 GLU n 
1 247 ILE n 
1 248 GLU n 
1 249 LYS n 
1 250 THR n 
1 251 ILE n 
1 252 ASN n 
1 253 MET n 
1 254 PHE n 
1 255 ALA n 
1 256 ALA n 
1 257 LEU n 
1 258 GLY n 
1 259 LEU n 
1 260 ASP n 
1 261 ASN n 
1 262 GLN n 
1 263 ILE n 
1 264 THR n 
1 265 GLY n 
1 266 LEU n 
1 267 ASP n 
1 268 VAL n 
1 269 SER n 
1 270 MET n 
1 271 TYR n 
1 272 GLY n 
1 273 TRP n 
1 274 PRO n 
1 275 PRO n 
1 276 ARG n 
1 277 ALA n 
1 278 TYR n 
1 279 PRO n 
1 280 THR n 
1 281 TYR n 
1 282 ASP n 
1 283 ALA n 
1 284 ILE n 
1 285 PRO n 
1 286 LYS n 
1 287 GLN n 
1 288 LYS n 
1 289 PHE n 
1 290 LEU n 
1 291 ASP n 
1 292 GLN n 
1 293 ALA n 
1 294 ALA n 
1 295 ARG n 
1 296 TYR n 
1 297 ASP n 
1 298 ARG n 
1 299 LEU n 
1 300 PHE n 
1 301 LYS n 
1 302 LEU n 
1 303 TYR n 
1 304 GLU n 
1 305 LYS n 
1 306 LEU n 
1 307 SER n 
1 308 ASP n 
1 309 LYS n 
1 310 ILE n 
1 311 SER n 
1 312 ASN n 
1 313 VAL n 
1 314 THR n 
1 315 PHE n 
1 316 TRP n 
1 317 GLY n 
1 318 ILE n 
1 319 ALA n 
1 320 ASP n 
1 321 ASN n 
1 322 HIS n 
1 323 THR n 
1 324 TRP n 
1 325 LEU n 
1 326 ASP n 
1 327 SER n 
1 328 ARG n 
1 329 ALA n 
1 330 ASP n 
1 331 VAL n 
1 332 TYR n 
1 333 TYR n 
1 334 ASP n 
1 335 ALA n 
1 336 ASN n 
1 337 GLY n 
1 338 ASN n 
1 339 VAL n 
1 340 VAL n 
1 341 VAL n 
1 342 ASP n 
1 343 PRO n 
1 344 ASN n 
1 345 ALA n 
1 346 PRO n 
1 347 TYR n 
1 348 ALA n 
1 349 LYS n 
1 350 VAL n 
1 351 GLU n 
1 352 LYS n 
1 353 GLY n 
1 354 LYS n 
1 355 GLY n 
1 356 LYS n 
1 357 ASP n 
1 358 ALA n 
1 359 PRO n 
1 360 PHE n 
1 361 VAL n 
1 362 PHE n 
1 363 GLY n 
1 364 PRO n 
1 365 ASP n 
1 366 TYR n 
1 367 LYS n 
1 368 VAL n 
1 369 LYS n 
1 370 PRO n 
1 371 ALA n 
1 372 TYR n 
1 373 TRP n 
1 374 ALA n 
1 375 ILE n 
1 376 ILE n 
1 377 ASP n 
1 378 HIS n 
1 379 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   379 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus proteiniphilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     860353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ? 'Cl -1'          35.453  
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   ALA 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   5   SER SER A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  PRO 10  10  10  PRO PRO A . n 
A 1 11  HIS 11  11  11  HIS HIS A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLN 22  22  22  GLN GLN A . n 
A 1 23  ARG 23  23  23  ARG ARG A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  PHE 28  28  28  PHE PHE A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  PRO 36  36  36  PRO PRO A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  GLN 40  40  40  GLN GLN A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  ASP 44  44  44  ASP ASP A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  MET 61  61  61  MET MET A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  SER 65  65  65  SER SER A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  LYS 72  72  72  LYS LYS A . n 
A 1 73  PHE 73  73  73  PHE PHE A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  PHE 75  75  75  PHE PHE A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  GLN 77  77  77  GLN GLN A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  ASN 88  88  88  ASN ASN A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ARG 93  93  93  ARG ARG A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  HIS 95  95  95  HIS HIS A . n 
A 1 96  THR 96  96  96  THR THR A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  TRP 99  99  99  TRP TRP A . n 
A 1 100 HIS 100 100 100 HIS HIS A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 GLN 105 105 105 GLN GLN A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 GLU 112 112 112 GLU GLU A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 PRO 115 115 115 PRO PRO A . n 
A 1 116 MET 116 116 116 MET MET A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLU 126 126 126 GLU GLU A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 ASN 128 128 128 ASN ASN A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 ARG 135 135 135 ARG ARG A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 THR 138 138 138 THR THR A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 GLU 145 145 145 GLU GLU A . n 
A 1 146 ARG 146 146 146 ARG ARG A . n 
A 1 147 TYR 147 147 147 TYR TYR A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 ASP 149 149 149 ASP ASP A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 ILE 151 151 151 ILE ILE A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 TRP 154 154 154 TRP TRP A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 LYS 166 166 166 LYS LYS A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 ASN 169 169 169 ASN ASN A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 ILE 175 175 175 ILE ILE A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 TYR 180 180 180 TYR TYR A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 GLN 186 186 186 GLN GLN A . n 
A 1 187 ALA 187 187 187 ALA ALA A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 ASN 195 195 195 ASN ASN A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 LEU 198 198 198 LEU LEU A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 MET 200 200 200 MET MET A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 GLU 206 206 206 GLU GLU A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 GLU 208 208 208 GLU GLU A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 TYR 215 215 215 TYR TYR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 LYS 219 219 219 LYS LYS A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 TRP 241 241 241 TRP TRP A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 GLU 246 246 246 GLU GLU A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 ILE 251 251 251 ILE ILE A . n 
A 1 252 ASN 252 252 252 ASN ASN A . n 
A 1 253 MET 253 253 253 MET MET A . n 
A 1 254 PHE 254 254 254 PHE PHE A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 ASN 261 261 261 ASN ASN A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 THR 264 264 264 THR THR A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 SER 269 269 269 SER SER A . n 
A 1 270 MET 270 270 270 MET MET A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 TRP 273 273 273 TRP TRP A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 PRO 275 275 275 PRO PRO A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 TYR 278 278 278 TYR TYR A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 ILE 284 284 284 ILE ILE A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 GLN 287 287 287 GLN GLN A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ASP 291 291 291 ASP ASP A . n 
A 1 292 GLN 292 292 292 GLN GLN A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 LEU 302 302 302 LEU LEU A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 SER 307 307 307 SER SER A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ILE 310 310 310 ILE ILE A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 THR 314 314 314 THR THR A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 TRP 316 316 316 TRP TRP A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ILE 318 318 318 ILE ILE A . n 
A 1 319 ALA 319 319 319 ALA ALA A . n 
A 1 320 ASP 320 320 320 ASP ASP A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 HIS 322 322 322 HIS HIS A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 TRP 324 324 324 TRP TRP A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 ARG 328 328 328 ARG ARG A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ASP 330 330 330 ASP ASP A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
A 1 332 TYR 332 332 332 TYR TYR A . n 
A 1 333 TYR 333 333 333 TYR TYR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 ASN 344 344 344 ASN ASN A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 PRO 346 346 346 PRO PRO A . n 
A 1 347 TYR 347 347 347 TYR TYR A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 GLU 351 351 351 GLU GLU A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 LYS 354 354 354 LYS LYS A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LYS 356 356 356 LYS LYS A . n 
A 1 357 ASP 357 357 357 ASP ASP A . n 
A 1 358 ALA 358 358 358 ALA ALA A . n 
A 1 359 PRO 359 359 359 PRO PRO A . n 
A 1 360 PHE 360 360 360 PHE PHE A . n 
A 1 361 VAL 361 361 361 VAL VAL A . n 
A 1 362 PHE 362 362 362 PHE PHE A . n 
A 1 363 GLY 363 363 363 GLY GLY A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 ASP 365 365 365 ASP ASP A . n 
A 1 366 TYR 366 366 366 TYR TYR A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 PRO 370 370 370 PRO PRO A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 TYR 372 372 372 TYR TYR A . n 
A 1 373 TRP 373 373 373 TRP TRP A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 ASP 377 377 377 ASP ASP A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 LYS 379 379 379 LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   401  1   ZN  ZN  A . 
C 2 ZN  1   402  2   ZN  ZN  A . 
D 2 ZN  1   403  3   ZN  ZN  A . 
E 2 ZN  1   404  4   ZN  ZN  A . 
F 2 ZN  1   405  5   ZN  ZN  A . 
G 2 ZN  1   406  6   ZN  ZN  A . 
H 3 CL  1   407  1   CL  CL  A . 
I 3 CL  1   408  2   CL  CL  A . 
J 4 HOH 1   501  318 HOH HOH A . 
J 4 HOH 2   502  374 HOH HOH A . 
J 4 HOH 3   503  423 HOH HOH A . 
J 4 HOH 4   504  391 HOH HOH A . 
J 4 HOH 5   505  501 HOH HOH A . 
J 4 HOH 6   506  127 HOH HOH A . 
J 4 HOH 7   507  437 HOH HOH A . 
J 4 HOH 8   508  156 HOH HOH A . 
J 4 HOH 9   509  310 HOH HOH A . 
J 4 HOH 10  510  99  HOH HOH A . 
J 4 HOH 11  511  231 HOH HOH A . 
J 4 HOH 12  512  115 HOH HOH A . 
J 4 HOH 13  513  208 HOH HOH A . 
J 4 HOH 14  514  70  HOH HOH A . 
J 4 HOH 15  515  351 HOH HOH A . 
J 4 HOH 16  516  197 HOH HOH A . 
J 4 HOH 17  517  162 HOH HOH A . 
J 4 HOH 18  518  315 HOH HOH A . 
J 4 HOH 19  519  194 HOH HOH A . 
J 4 HOH 20  520  142 HOH HOH A . 
J 4 HOH 21  521  458 HOH HOH A . 
J 4 HOH 22  522  62  HOH HOH A . 
J 4 HOH 23  523  91  HOH HOH A . 
J 4 HOH 24  524  207 HOH HOH A . 
J 4 HOH 25  525  105 HOH HOH A . 
J 4 HOH 26  526  336 HOH HOH A . 
J 4 HOH 27  527  312 HOH HOH A . 
J 4 HOH 28  528  167 HOH HOH A . 
J 4 HOH 29  529  248 HOH HOH A . 
J 4 HOH 30  530  17  HOH HOH A . 
J 4 HOH 31  531  104 HOH HOH A . 
J 4 HOH 32  532  61  HOH HOH A . 
J 4 HOH 33  533  129 HOH HOH A . 
J 4 HOH 34  534  1   HOH HOH A . 
J 4 HOH 35  535  265 HOH HOH A . 
J 4 HOH 36  536  183 HOH HOH A . 
J 4 HOH 37  537  416 HOH HOH A . 
J 4 HOH 38  538  120 HOH HOH A . 
J 4 HOH 39  539  338 HOH HOH A . 
J 4 HOH 40  540  128 HOH HOH A . 
J 4 HOH 41  541  136 HOH HOH A . 
J 4 HOH 42  542  79  HOH HOH A . 
J 4 HOH 43  543  51  HOH HOH A . 
J 4 HOH 44  544  8   HOH HOH A . 
J 4 HOH 45  545  339 HOH HOH A . 
J 4 HOH 46  546  344 HOH HOH A . 
J 4 HOH 47  547  233 HOH HOH A . 
J 4 HOH 48  548  234 HOH HOH A . 
J 4 HOH 49  549  454 HOH HOH A . 
J 4 HOH 50  550  246 HOH HOH A . 
J 4 HOH 51  551  255 HOH HOH A . 
J 4 HOH 52  552  84  HOH HOH A . 
J 4 HOH 53  553  140 HOH HOH A . 
J 4 HOH 54  554  502 HOH HOH A . 
J 4 HOH 55  555  240 HOH HOH A . 
J 4 HOH 56  556  12  HOH HOH A . 
J 4 HOH 57  557  92  HOH HOH A . 
J 4 HOH 58  558  304 HOH HOH A . 
J 4 HOH 59  559  286 HOH HOH A . 
J 4 HOH 60  560  47  HOH HOH A . 
J 4 HOH 61  561  402 HOH HOH A . 
J 4 HOH 62  562  317 HOH HOH A . 
J 4 HOH 63  563  256 HOH HOH A . 
J 4 HOH 64  564  42  HOH HOH A . 
J 4 HOH 65  565  348 HOH HOH A . 
J 4 HOH 66  566  4   HOH HOH A . 
J 4 HOH 67  567  113 HOH HOH A . 
J 4 HOH 68  568  135 HOH HOH A . 
J 4 HOH 69  569  46  HOH HOH A . 
J 4 HOH 70  570  182 HOH HOH A . 
J 4 HOH 71  571  420 HOH HOH A . 
J 4 HOH 72  572  38  HOH HOH A . 
J 4 HOH 73  573  475 HOH HOH A . 
J 4 HOH 74  574  25  HOH HOH A . 
J 4 HOH 75  575  320 HOH HOH A . 
J 4 HOH 76  576  211 HOH HOH A . 
J 4 HOH 77  577  229 HOH HOH A . 
J 4 HOH 78  578  196 HOH HOH A . 
J 4 HOH 79  579  216 HOH HOH A . 
J 4 HOH 80  580  50  HOH HOH A . 
J 4 HOH 81  581  6   HOH HOH A . 
J 4 HOH 82  582  361 HOH HOH A . 
J 4 HOH 83  583  184 HOH HOH A . 
J 4 HOH 84  584  152 HOH HOH A . 
J 4 HOH 85  585  34  HOH HOH A . 
J 4 HOH 86  586  179 HOH HOH A . 
J 4 HOH 87  587  382 HOH HOH A . 
J 4 HOH 88  588  440 HOH HOH A . 
J 4 HOH 89  589  147 HOH HOH A . 
J 4 HOH 90  590  74  HOH HOH A . 
J 4 HOH 91  591  244 HOH HOH A . 
J 4 HOH 92  592  487 HOH HOH A . 
J 4 HOH 93  593  209 HOH HOH A . 
J 4 HOH 94  594  119 HOH HOH A . 
J 4 HOH 95  595  96  HOH HOH A . 
J 4 HOH 96  596  75  HOH HOH A . 
J 4 HOH 97  597  215 HOH HOH A . 
J 4 HOH 98  598  263 HOH HOH A . 
J 4 HOH 99  599  107 HOH HOH A . 
J 4 HOH 100 600  141 HOH HOH A . 
J 4 HOH 101 601  10  HOH HOH A . 
J 4 HOH 102 602  20  HOH HOH A . 
J 4 HOH 103 603  177 HOH HOH A . 
J 4 HOH 104 604  53  HOH HOH A . 
J 4 HOH 105 605  117 HOH HOH A . 
J 4 HOH 106 606  11  HOH HOH A . 
J 4 HOH 107 607  225 HOH HOH A . 
J 4 HOH 108 608  171 HOH HOH A . 
J 4 HOH 109 609  174 HOH HOH A . 
J 4 HOH 110 610  195 HOH HOH A . 
J 4 HOH 111 611  170 HOH HOH A . 
J 4 HOH 112 612  65  HOH HOH A . 
J 4 HOH 113 613  285 HOH HOH A . 
J 4 HOH 114 614  132 HOH HOH A . 
J 4 HOH 115 615  40  HOH HOH A . 
J 4 HOH 116 616  21  HOH HOH A . 
J 4 HOH 117 617  328 HOH HOH A . 
J 4 HOH 118 618  19  HOH HOH A . 
J 4 HOH 119 619  493 HOH HOH A . 
J 4 HOH 120 620  131 HOH HOH A . 
J 4 HOH 121 621  69  HOH HOH A . 
J 4 HOH 122 622  81  HOH HOH A . 
J 4 HOH 123 623  247 HOH HOH A . 
J 4 HOH 124 624  488 HOH HOH A . 
J 4 HOH 125 625  251 HOH HOH A . 
J 4 HOH 126 626  413 HOH HOH A . 
J 4 HOH 127 627  427 HOH HOH A . 
J 4 HOH 128 628  343 HOH HOH A . 
J 4 HOH 129 629  39  HOH HOH A . 
J 4 HOH 130 630  29  HOH HOH A . 
J 4 HOH 131 631  280 HOH HOH A . 
J 4 HOH 132 632  83  HOH HOH A . 
J 4 HOH 133 633  56  HOH HOH A . 
J 4 HOH 134 634  219 HOH HOH A . 
J 4 HOH 135 635  112 HOH HOH A . 
J 4 HOH 136 636  116 HOH HOH A . 
J 4 HOH 137 637  279 HOH HOH A . 
J 4 HOH 138 638  157 HOH HOH A . 
J 4 HOH 139 639  387 HOH HOH A . 
J 4 HOH 140 640  396 HOH HOH A . 
J 4 HOH 141 641  461 HOH HOH A . 
J 4 HOH 142 642  44  HOH HOH A . 
J 4 HOH 143 643  433 HOH HOH A . 
J 4 HOH 144 644  302 HOH HOH A . 
J 4 HOH 145 645  192 HOH HOH A . 
J 4 HOH 146 646  465 HOH HOH A . 
J 4 HOH 147 647  23  HOH HOH A . 
J 4 HOH 148 648  106 HOH HOH A . 
J 4 HOH 149 649  316 HOH HOH A . 
J 4 HOH 150 650  347 HOH HOH A . 
J 4 HOH 151 651  35  HOH HOH A . 
J 4 HOH 152 652  176 HOH HOH A . 
J 4 HOH 153 653  31  HOH HOH A . 
J 4 HOH 154 654  108 HOH HOH A . 
J 4 HOH 155 655  169 HOH HOH A . 
J 4 HOH 156 656  111 HOH HOH A . 
J 4 HOH 157 657  148 HOH HOH A . 
J 4 HOH 158 658  30  HOH HOH A . 
J 4 HOH 159 659  43  HOH HOH A . 
J 4 HOH 160 660  77  HOH HOH A . 
J 4 HOH 161 661  393 HOH HOH A . 
J 4 HOH 162 662  341 HOH HOH A . 
J 4 HOH 163 663  185 HOH HOH A . 
J 4 HOH 164 664  292 HOH HOH A . 
J 4 HOH 165 665  14  HOH HOH A . 
J 4 HOH 166 666  467 HOH HOH A . 
J 4 HOH 167 667  289 HOH HOH A . 
J 4 HOH 168 668  32  HOH HOH A . 
J 4 HOH 169 669  406 HOH HOH A . 
J 4 HOH 170 670  36  HOH HOH A . 
J 4 HOH 171 671  224 HOH HOH A . 
J 4 HOH 172 672  33  HOH HOH A . 
J 4 HOH 173 673  26  HOH HOH A . 
J 4 HOH 174 674  89  HOH HOH A . 
J 4 HOH 175 675  5   HOH HOH A . 
J 4 HOH 176 676  45  HOH HOH A . 
J 4 HOH 177 677  109 HOH HOH A . 
J 4 HOH 178 678  164 HOH HOH A . 
J 4 HOH 179 679  86  HOH HOH A . 
J 4 HOH 180 680  254 HOH HOH A . 
J 4 HOH 181 681  218 HOH HOH A . 
J 4 HOH 182 682  175 HOH HOH A . 
J 4 HOH 183 683  212 HOH HOH A . 
J 4 HOH 184 684  213 HOH HOH A . 
J 4 HOH 185 685  122 HOH HOH A . 
J 4 HOH 186 686  275 HOH HOH A . 
J 4 HOH 187 687  407 HOH HOH A . 
J 4 HOH 188 688  154 HOH HOH A . 
J 4 HOH 189 689  334 HOH HOH A . 
J 4 HOH 190 690  203 HOH HOH A . 
J 4 HOH 191 691  72  HOH HOH A . 
J 4 HOH 192 692  357 HOH HOH A . 
J 4 HOH 193 693  52  HOH HOH A . 
J 4 HOH 194 694  276 HOH HOH A . 
J 4 HOH 195 695  166 HOH HOH A . 
J 4 HOH 196 696  241 HOH HOH A . 
J 4 HOH 197 697  181 HOH HOH A . 
J 4 HOH 198 698  235 HOH HOH A . 
J 4 HOH 199 699  380 HOH HOH A . 
J 4 HOH 200 700  18  HOH HOH A . 
J 4 HOH 201 701  190 HOH HOH A . 
J 4 HOH 202 702  15  HOH HOH A . 
J 4 HOH 203 703  73  HOH HOH A . 
J 4 HOH 204 704  94  HOH HOH A . 
J 4 HOH 205 705  85  HOH HOH A . 
J 4 HOH 206 706  146 HOH HOH A . 
J 4 HOH 207 707  370 HOH HOH A . 
J 4 HOH 208 708  372 HOH HOH A . 
J 4 HOH 209 709  477 HOH HOH A . 
J 4 HOH 210 710  296 HOH HOH A . 
J 4 HOH 211 711  468 HOH HOH A . 
J 4 HOH 212 712  159 HOH HOH A . 
J 4 HOH 213 713  227 HOH HOH A . 
J 4 HOH 214 714  67  HOH HOH A . 
J 4 HOH 215 715  60  HOH HOH A . 
J 4 HOH 216 716  88  HOH HOH A . 
J 4 HOH 217 717  103 HOH HOH A . 
J 4 HOH 218 718  428 HOH HOH A . 
J 4 HOH 219 719  24  HOH HOH A . 
J 4 HOH 220 720  397 HOH HOH A . 
J 4 HOH 221 721  260 HOH HOH A . 
J 4 HOH 222 722  327 HOH HOH A . 
J 4 HOH 223 723  133 HOH HOH A . 
J 4 HOH 224 724  158 HOH HOH A . 
J 4 HOH 225 725  37  HOH HOH A . 
J 4 HOH 226 726  160 HOH HOH A . 
J 4 HOH 227 727  236 HOH HOH A . 
J 4 HOH 228 728  16  HOH HOH A . 
J 4 HOH 229 729  68  HOH HOH A . 
J 4 HOH 230 730  28  HOH HOH A . 
J 4 HOH 231 731  200 HOH HOH A . 
J 4 HOH 232 732  478 HOH HOH A . 
J 4 HOH 233 733  439 HOH HOH A . 
J 4 HOH 234 734  98  HOH HOH A . 
J 4 HOH 235 735  474 HOH HOH A . 
J 4 HOH 236 736  445 HOH HOH A . 
J 4 HOH 237 737  434 HOH HOH A . 
J 4 HOH 238 738  126 HOH HOH A . 
J 4 HOH 239 739  165 HOH HOH A . 
J 4 HOH 240 740  22  HOH HOH A . 
J 4 HOH 241 741  435 HOH HOH A . 
J 4 HOH 242 742  118 HOH HOH A . 
J 4 HOH 243 743  57  HOH HOH A . 
J 4 HOH 244 744  188 HOH HOH A . 
J 4 HOH 245 745  472 HOH HOH A . 
J 4 HOH 246 746  145 HOH HOH A . 
J 4 HOH 247 747  55  HOH HOH A . 
J 4 HOH 248 748  368 HOH HOH A . 
J 4 HOH 249 749  82  HOH HOH A . 
J 4 HOH 250 750  49  HOH HOH A . 
J 4 HOH 251 751  451 HOH HOH A . 
J 4 HOH 252 752  360 HOH HOH A . 
J 4 HOH 253 753  27  HOH HOH A . 
J 4 HOH 254 754  230 HOH HOH A . 
J 4 HOH 255 755  350 HOH HOH A . 
J 4 HOH 256 756  41  HOH HOH A . 
J 4 HOH 257 757  446 HOH HOH A . 
J 4 HOH 258 758  232 HOH HOH A . 
J 4 HOH 259 759  464 HOH HOH A . 
J 4 HOH 260 760  258 HOH HOH A . 
J 4 HOH 261 761  64  HOH HOH A . 
J 4 HOH 262 762  486 HOH HOH A . 
J 4 HOH 263 763  495 HOH HOH A . 
J 4 HOH 264 764  297 HOH HOH A . 
J 4 HOH 265 765  463 HOH HOH A . 
J 4 HOH 266 766  442 HOH HOH A . 
J 4 HOH 267 767  282 HOH HOH A . 
J 4 HOH 268 768  306 HOH HOH A . 
J 4 HOH 269 769  125 HOH HOH A . 
J 4 HOH 270 770  191 HOH HOH A . 
J 4 HOH 271 771  443 HOH HOH A . 
J 4 HOH 272 772  13  HOH HOH A . 
J 4 HOH 273 773  9   HOH HOH A . 
J 4 HOH 274 774  250 HOH HOH A . 
J 4 HOH 275 775  130 HOH HOH A . 
J 4 HOH 276 776  323 HOH HOH A . 
J 4 HOH 277 777  394 HOH HOH A . 
J 4 HOH 278 778  161 HOH HOH A . 
J 4 HOH 279 779  223 HOH HOH A . 
J 4 HOH 280 780  358 HOH HOH A . 
J 4 HOH 281 781  87  HOH HOH A . 
J 4 HOH 282 782  123 HOH HOH A . 
J 4 HOH 283 783  198 HOH HOH A . 
J 4 HOH 284 784  48  HOH HOH A . 
J 4 HOH 285 785  277 HOH HOH A . 
J 4 HOH 286 786  410 HOH HOH A . 
J 4 HOH 287 787  469 HOH HOH A . 
J 4 HOH 288 788  71  HOH HOH A . 
J 4 HOH 289 789  401 HOH HOH A . 
J 4 HOH 290 790  100 HOH HOH A . 
J 4 HOH 291 791  149 HOH HOH A . 
J 4 HOH 292 792  78  HOH HOH A . 
J 4 HOH 293 793  353 HOH HOH A . 
J 4 HOH 294 794  63  HOH HOH A . 
J 4 HOH 295 795  59  HOH HOH A . 
J 4 HOH 296 796  114 HOH HOH A . 
J 4 HOH 297 797  272 HOH HOH A . 
J 4 HOH 298 798  201 HOH HOH A . 
J 4 HOH 299 799  283 HOH HOH A . 
J 4 HOH 300 800  144 HOH HOH A . 
J 4 HOH 301 801  331 HOH HOH A . 
J 4 HOH 302 802  93  HOH HOH A . 
J 4 HOH 303 803  271 HOH HOH A . 
J 4 HOH 304 804  421 HOH HOH A . 
J 4 HOH 305 805  150 HOH HOH A . 
J 4 HOH 306 806  97  HOH HOH A . 
J 4 HOH 307 807  381 HOH HOH A . 
J 4 HOH 308 808  80  HOH HOH A . 
J 4 HOH 309 809  137 HOH HOH A . 
J 4 HOH 310 810  309 HOH HOH A . 
J 4 HOH 311 811  303 HOH HOH A . 
J 4 HOH 312 812  95  HOH HOH A . 
J 4 HOH 313 813  66  HOH HOH A . 
J 4 HOH 314 814  293 HOH HOH A . 
J 4 HOH 315 815  269 HOH HOH A . 
J 4 HOH 316 816  76  HOH HOH A . 
J 4 HOH 317 817  399 HOH HOH A . 
J 4 HOH 318 818  220 HOH HOH A . 
J 4 HOH 319 819  206 HOH HOH A . 
J 4 HOH 320 820  210 HOH HOH A . 
J 4 HOH 321 821  101 HOH HOH A . 
J 4 HOH 322 822  414 HOH HOH A . 
J 4 HOH 323 823  290 HOH HOH A . 
J 4 HOH 324 824  288 HOH HOH A . 
J 4 HOH 325 825  412 HOH HOH A . 
J 4 HOH 326 826  466 HOH HOH A . 
J 4 HOH 327 827  58  HOH HOH A . 
J 4 HOH 328 828  333 HOH HOH A . 
J 4 HOH 329 829  483 HOH HOH A . 
J 4 HOH 330 830  342 HOH HOH A . 
J 4 HOH 331 831  54  HOH HOH A . 
J 4 HOH 332 832  415 HOH HOH A . 
J 4 HOH 333 833  187 HOH HOH A . 
J 4 HOH 334 834  180 HOH HOH A . 
J 4 HOH 335 835  369 HOH HOH A . 
J 4 HOH 336 836  432 HOH HOH A . 
J 4 HOH 337 837  449 HOH HOH A . 
J 4 HOH 338 838  460 HOH HOH A . 
J 4 HOH 339 839  384 HOH HOH A . 
J 4 HOH 340 840  322 HOH HOH A . 
J 4 HOH 341 841  253 HOH HOH A . 
J 4 HOH 342 842  436 HOH HOH A . 
J 4 HOH 343 843  386 HOH HOH A . 
J 4 HOH 344 844  484 HOH HOH A . 
J 4 HOH 345 845  3   HOH HOH A . 
J 4 HOH 346 846  485 HOH HOH A . 
J 4 HOH 347 847  459 HOH HOH A . 
J 4 HOH 348 848  352 HOH HOH A . 
J 4 HOH 349 849  202 HOH HOH A . 
J 4 HOH 350 850  389 HOH HOH A . 
J 4 HOH 351 851  373 HOH HOH A . 
J 4 HOH 352 852  134 HOH HOH A . 
J 4 HOH 353 853  264 HOH HOH A . 
J 4 HOH 354 854  172 HOH HOH A . 
J 4 HOH 355 855  444 HOH HOH A . 
J 4 HOH 356 856  479 HOH HOH A . 
J 4 HOH 357 857  228 HOH HOH A . 
J 4 HOH 358 858  489 HOH HOH A . 
J 4 HOH 359 859  186 HOH HOH A . 
J 4 HOH 360 860  267 HOH HOH A . 
J 4 HOH 361 861  121 HOH HOH A . 
J 4 HOH 362 862  398 HOH HOH A . 
J 4 HOH 363 863  480 HOH HOH A . 
J 4 HOH 364 864  124 HOH HOH A . 
J 4 HOH 365 865  491 HOH HOH A . 
J 4 HOH 366 866  356 HOH HOH A . 
J 4 HOH 367 867  429 HOH HOH A . 
J 4 HOH 368 868  362 HOH HOH A . 
J 4 HOH 369 869  378 HOH HOH A . 
J 4 HOH 370 870  457 HOH HOH A . 
J 4 HOH 371 871  375 HOH HOH A . 
J 4 HOH 372 872  2   HOH HOH A . 
J 4 HOH 373 873  499 HOH HOH A . 
J 4 HOH 374 874  349 HOH HOH A . 
J 4 HOH 375 875  426 HOH HOH A . 
J 4 HOH 376 876  500 HOH HOH A . 
J 4 HOH 377 877  259 HOH HOH A . 
J 4 HOH 378 878  90  HOH HOH A . 
J 4 HOH 379 879  405 HOH HOH A . 
J 4 HOH 380 880  395 HOH HOH A . 
J 4 HOH 381 881  298 HOH HOH A . 
J 4 HOH 382 882  367 HOH HOH A . 
J 4 HOH 383 883  424 HOH HOH A . 
J 4 HOH 384 884  377 HOH HOH A . 
J 4 HOH 385 885  498 HOH HOH A . 
J 4 HOH 386 886  419 HOH HOH A . 
J 4 HOH 387 887  388 HOH HOH A . 
J 4 HOH 388 888  222 HOH HOH A . 
J 4 HOH 389 889  110 HOH HOH A . 
J 4 HOH 390 890  243 HOH HOH A . 
J 4 HOH 391 891  226 HOH HOH A . 
J 4 HOH 392 892  385 HOH HOH A . 
J 4 HOH 393 893  204 HOH HOH A . 
J 4 HOH 394 894  456 HOH HOH A . 
J 4 HOH 395 895  379 HOH HOH A . 
J 4 HOH 396 896  494 HOH HOH A . 
J 4 HOH 397 897  496 HOH HOH A . 
J 4 HOH 398 898  455 HOH HOH A . 
J 4 HOH 399 899  447 HOH HOH A . 
J 4 HOH 400 900  193 HOH HOH A . 
J 4 HOH 401 901  490 HOH HOH A . 
J 4 HOH 402 902  319 HOH HOH A . 
J 4 HOH 403 903  364 HOH HOH A . 
J 4 HOH 404 904  330 HOH HOH A . 
J 4 HOH 405 905  497 HOH HOH A . 
J 4 HOH 406 906  408 HOH HOH A . 
J 4 HOH 407 907  284 HOH HOH A . 
J 4 HOH 408 908  168 HOH HOH A . 
J 4 HOH 409 909  366 HOH HOH A . 
J 4 HOH 410 910  332 HOH HOH A . 
J 4 HOH 411 911  7   HOH HOH A . 
J 4 HOH 412 912  492 HOH HOH A . 
J 4 HOH 413 913  383 HOH HOH A . 
J 4 HOH 414 914  143 HOH HOH A . 
J 4 HOH 415 915  301 HOH HOH A . 
J 4 HOH 416 916  261 HOH HOH A . 
J 4 HOH 417 917  325 HOH HOH A . 
J 4 HOH 418 918  337 HOH HOH A . 
J 4 HOH 419 919  199 HOH HOH A . 
J 4 HOH 420 920  305 HOH HOH A . 
J 4 HOH 421 921  409 HOH HOH A . 
J 4 HOH 422 922  151 HOH HOH A . 
J 4 HOH 423 923  163 HOH HOH A . 
J 4 HOH 424 924  471 HOH HOH A . 
J 4 HOH 425 925  102 HOH HOH A . 
J 4 HOH 426 926  242 HOH HOH A . 
J 4 HOH 427 927  425 HOH HOH A . 
J 4 HOH 428 928  431 HOH HOH A . 
J 4 HOH 429 929  346 HOH HOH A . 
J 4 HOH 430 930  273 HOH HOH A . 
J 4 HOH 431 931  294 HOH HOH A . 
J 4 HOH 432 932  448 HOH HOH A . 
J 4 HOH 433 933  313 HOH HOH A . 
J 4 HOH 434 934  221 HOH HOH A . 
J 4 HOH 435 935  270 HOH HOH A . 
J 4 HOH 436 936  390 HOH HOH A . 
J 4 HOH 437 937  307 HOH HOH A . 
J 4 HOH 438 938  173 HOH HOH A . 
J 4 HOH 439 939  245 HOH HOH A . 
J 4 HOH 440 940  262 HOH HOH A . 
J 4 HOH 441 941  452 HOH HOH A . 
J 4 HOH 442 942  504 HOH HOH A . 
J 4 HOH 443 943  308 HOH HOH A . 
J 4 HOH 444 944  205 HOH HOH A . 
J 4 HOH 445 945  476 HOH HOH A . 
J 4 HOH 446 946  217 HOH HOH A . 
J 4 HOH 447 947  153 HOH HOH A . 
J 4 HOH 448 948  324 HOH HOH A . 
J 4 HOH 449 949  329 HOH HOH A . 
J 4 HOH 450 950  400 HOH HOH A . 
J 4 HOH 451 951  299 HOH HOH A . 
J 4 HOH 452 952  392 HOH HOH A . 
J 4 HOH 453 953  178 HOH HOH A . 
J 4 HOH 454 954  278 HOH HOH A . 
J 4 HOH 455 955  237 HOH HOH A . 
J 4 HOH 456 956  359 HOH HOH A . 
J 4 HOH 457 957  371 HOH HOH A . 
J 4 HOH 458 958  411 HOH HOH A . 
J 4 HOH 459 959  473 HOH HOH A . 
J 4 HOH 460 960  300 HOH HOH A . 
J 4 HOH 461 961  450 HOH HOH A . 
J 4 HOH 462 962  403 HOH HOH A . 
J 4 HOH 463 963  295 HOH HOH A . 
J 4 HOH 464 964  503 HOH HOH A . 
J 4 HOH 465 965  335 HOH HOH A . 
J 4 HOH 466 966  214 HOH HOH A . 
J 4 HOH 467 967  281 HOH HOH A . 
J 4 HOH 468 968  462 HOH HOH A . 
J 4 HOH 469 969  430 HOH HOH A . 
J 4 HOH 470 970  365 HOH HOH A . 
J 4 HOH 471 971  311 HOH HOH A . 
J 4 HOH 472 972  470 HOH HOH A . 
J 4 HOH 473 973  355 HOH HOH A . 
J 4 HOH 474 974  239 HOH HOH A . 
J 4 HOH 475 975  138 HOH HOH A . 
J 4 HOH 476 976  155 HOH HOH A . 
J 4 HOH 477 977  252 HOH HOH A . 
J 4 HOH 478 978  189 HOH HOH A . 
J 4 HOH 479 979  321 HOH HOH A . 
J 4 HOH 480 980  418 HOH HOH A . 
J 4 HOH 481 981  249 HOH HOH A . 
J 4 HOH 482 982  404 HOH HOH A . 
J 4 HOH 483 983  238 HOH HOH A . 
J 4 HOH 484 984  139 HOH HOH A . 
J 4 HOH 485 985  345 HOH HOH A . 
J 4 HOH 486 986  438 HOH HOH A . 
J 4 HOH 487 987  274 HOH HOH A . 
J 4 HOH 488 988  376 HOH HOH A . 
J 4 HOH 489 989  314 HOH HOH A . 
J 4 HOH 490 990  363 HOH HOH A . 
J 4 HOH 491 991  326 HOH HOH A . 
J 4 HOH 492 992  291 HOH HOH A . 
J 4 HOH 493 993  453 HOH HOH A . 
J 4 HOH 494 994  268 HOH HOH A . 
J 4 HOH 495 995  354 HOH HOH A . 
J 4 HOH 496 996  482 HOH HOH A . 
J 4 HOH 497 997  257 HOH HOH A . 
J 4 HOH 498 998  340 HOH HOH A . 
J 4 HOH 499 999  417 HOH HOH A . 
J 4 HOH 500 1000 266 HOH HOH A . 
J 4 HOH 501 1001 441 HOH HOH A . 
J 4 HOH 502 1002 481 HOH HOH A . 
J 4 HOH 503 1003 287 HOH HOH A . 
J 4 HOH 504 1004 422 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.319 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FK8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     88.871 
_cell.length_a_esd                 ? 
_cell.length_b                     61.555 
_cell.length_b_esd                 ? 
_cell.length_c                     110.771 
_cell.length_c_esd                 ? 
_cell.volume                       584442.702 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FK8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FK8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          63.14 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '14% PEG 5K, 0.1M MES buffer at pH 6.5 and 0.02M Zinc chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 200K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-09-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          15.56 
_reflns.entry_id                                       9FK8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.10 
_reflns.d_resolution_low                               50.10 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     33811 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.07 
_reflns.pdbx_Rpim_I_all                                0.03 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.17 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.8 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2721 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.32 
_reflns_shell.pdbx_Rpim_I_all                               0.18 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.91 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.26 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               17.69 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FK8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             50.00 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     33785 
_refine.ls_number_reflns_R_free                  1657 
_refine.ls_number_reflns_R_work                  32128 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.64 
_refine.ls_percent_reflns_R_free                 4.90 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1526 
_refine.ls_R_factor_R_free                       0.1898 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1507 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.4381 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1920 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10 
_refine_hist.d_res_low                        50.00 
_refine_hist.number_atoms_solvent             504 
_refine_hist.number_atoms_total               3578 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3066 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0076 ? 3149 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8255 ? 4269 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0512 ? 443  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0055 ? 555  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.8687 ? 410  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10 2.16  . . 138 2622 98.57  . . . . 0.1814 . . . . . . . . . . . 0.2489 
'X-RAY DIFFRACTION' 2.16 2.23  . . 135 2633 99.10  . . . . 0.1706 . . . . . . . . . . . 0.1947 
'X-RAY DIFFRACTION' 2.23 2.31  . . 151 2651 99.33  . . . . 0.1584 . . . . . . . . . . . 0.1962 
'X-RAY DIFFRACTION' 2.31 2.40  . . 151 2660 99.57  . . . . 0.1572 . . . . . . . . . . . 0.2042 
'X-RAY DIFFRACTION' 2.40 2.51  . . 120 2682 99.82  . . . . 0.1514 . . . . . . . . . . . 0.2176 
'X-RAY DIFFRACTION' 2.51 2.65  . . 137 2669 99.79  . . . . 0.1572 . . . . . . . . . . . 0.2003 
'X-RAY DIFFRACTION' 2.65 2.81  . . 139 2669 99.93  . . . . 0.1543 . . . . . . . . . . . 0.2020 
'X-RAY DIFFRACTION' 2.81 3.03  . . 119 2693 100.00 . . . . 0.1593 . . . . . . . . . . . 0.1885 
'X-RAY DIFFRACTION' 3.03 3.33  . . 158 2669 99.96  . . . . 0.1528 . . . . . . . . . . . 0.2065 
'X-RAY DIFFRACTION' 3.33 3.82  . . 147 2702 99.93  . . . . 0.1400 . . . . . . . . . . . 0.1964 
'X-RAY DIFFRACTION' 3.82 4.81  . . 136 2706 100.00 . . . . 0.1271 . . . . . . . . . . . 0.1370 
'X-RAY DIFFRACTION' 4.81 50.00 . . 126 2772 99.66  . . . . 0.1508 . . . . . . . . . . . 0.1758 
# 
_struct.entry_id                     9FK8 
_struct.title                        'The structure of XT6 from G.proteiniphilus T-6: The E265G/N158T mutant' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FK8 
_struct_keywords.text            'XT6, glycosynthase, hydrolase, Geobacillus proteiniphilus T-6' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 3 ? 
I N N 3 ? 
J N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    XYN1_GEOSE 
_struct_ref.pdbx_db_accession          P40943 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITELDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_struct_ref.pdbx_align_begin           29 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FK8 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 379 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P40943 
_struct_ref_seq.db_align_beg                  29 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  407 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       379 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FK8 THR A 158 ? UNP P40943 ASN 186 'engineered mutation' 158 1 
1 9FK8 GLY A 265 ? UNP P40943 GLU 293 'engineered mutation' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 830   ? 
1 MORE         -192  ? 
1 'SSA (A^2)'  15860 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 13  ? ALA A 17  ? SER A 13  ALA A 17  5 ? 5  
HELX_P HELX_P2  AA2 GLN A 19  ? TYR A 24  ? GLN A 19  TYR A 24  1 ? 6  
HELX_P HELX_P3  AA3 GLU A 35  ? GLN A 40  ? GLU A 35  GLN A 40  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 41  ? PHE A 52  ? ASN A 41  PHE A 52  1 ? 12 
HELX_P HELX_P5  AA5 LYS A 62  ? GLN A 67  ? LYS A 62  GLN A 67  1 ? 6  
HELX_P HELX_P6  AA6 PHE A 75  ? ASN A 88  ? PHE A 75  ASN A 88  1 ? 14 
HELX_P HELX_P7  AA7 PRO A 104 ? LEU A 109 ? PRO A 104 LEU A 109 5 ? 6  
HELX_P HELX_P8  AA8 PRO A 115 ? GLU A 119 ? PRO A 115 GLU A 119 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 121 ? LYS A 148 ? ASP A 121 LYS A 148 1 ? 28 
HELX_P HELX_P10 AB1 SER A 170 ? GLY A 177 ? SER A 170 GLY A 177 1 ? 8  
HELX_P HELX_P11 AB2 ILE A 178 ? GLY A 193 ? ILE A 178 GLY A 193 1 ? 16 
HELX_P HELX_P12 AB3 PRO A 209 ? GLU A 224 ? PRO A 209 GLU A 224 1 ? 16 
HELX_P HELX_P13 AB4 SER A 243 ? ALA A 256 ? SER A 243 ALA A 256 1 ? 14 
HELX_P HELX_P14 AB5 PRO A 285 ? LEU A 306 ? PRO A 285 LEU A 306 1 ? 22 
HELX_P HELX_P15 AB6 THR A 323 ? ALA A 329 ? THR A 323 ALA A 329 5 ? 7  
HELX_P HELX_P16 AB7 LYS A 369 ? ASP A 377 ? LYS A 369 ASP A 377 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 11  NE2 ? ? ? 1_555 G ZN  . ZN ? ? A HIS 11  A ZN  406 4_454 ? ? ? ? ? ? ? 2.102 ? ? 
metalc2  metalc ? ? A ASP 21  OD2 ? ? ? 1_555 F ZN  . ZN ? ? A ASP 21  A ZN  405 1_555 ? ? ? ? ? ? ? 2.060 ? ? 
metalc3  metalc ? ? A GLU 27  O   ? ? ? 1_555 C ZN  . ZN ? ? A GLU 27  A ZN  402 1_555 ? ? ? ? ? ? ? 2.325 ? ? 
metalc4  metalc ? ? A GLU 27  OE2 ? ? ? 1_555 G ZN  . ZN ? ? A GLU 27  A ZN  406 1_555 ? ? ? ? ? ? ? 2.100 ? ? 
metalc5  metalc ? ? A GLU 58  OE1 ? ? ? 1_555 B ZN  . ZN ? ? A GLU 58  A ZN  401 1_555 ? ? ? ? ? ? ? 1.989 ? ? 
metalc6  metalc ? ? A ASP 282 OD2 ? ? ? 1_555 D ZN  . ZN ? ? A ASP 282 A ZN  403 1_555 ? ? ? ? ? ? ? 2.203 ? ? 
metalc7  metalc ? ? A ASP 297 OD1 ? ? ? 1_555 E ZN  . ZN ? ? A ASP 297 A ZN  404 1_555 ? ? ? ? ? ? ? 2.381 ? ? 
metalc8  metalc ? ? A SER 307 O   ? ? ? 1_555 C ZN  . ZN ? ? A SER 307 A ZN  402 1_555 ? ? ? ? ? ? ? 2.354 ? ? 
metalc9  metalc ? ? A ILE 310 O   ? ? ? 1_555 C ZN  . ZN ? ? A ILE 310 A ZN  402 1_555 ? ? ? ? ? ? ? 2.418 ? ? 
metalc10 metalc ? ? A HIS 322 NE2 ? ? ? 1_555 B ZN  . ZN ? ? A HIS 322 A ZN  401 1_555 ? ? ? ? ? ? ? 1.953 ? ? 
metalc11 metalc ? ? A ASP 365 OD2 ? ? ? 1_555 G ZN  . ZN ? ? A ASP 365 A ZN  406 4_454 ? ? ? ? ? ? ? 2.000 ? ? 
metalc12 metalc ? ? A ALA 374 O   ? ? ? 1_555 E ZN  . ZN ? ? A ALA 374 A ZN  404 1_555 ? ? ? ? ? ? ? 2.313 ? ? 
metalc13 metalc ? ? A ASP 377 OD1 ? ? ? 1_555 E ZN  . ZN ? ? A ASP 377 A ZN  404 1_555 ? ? ? ? ? ? ? 2.506 ? ? 
metalc14 metalc ? ? A HIS 378 NE2 ? ? ? 1_555 D ZN  . ZN ? ? A HIS 378 A ZN  403 4_444 ? ? ? ? ? ? ? 2.127 ? ? 
metalc15 metalc ? ? A LYS 379 O   ? ? ? 1_555 E ZN  . ZN ? ? A LYS 379 A ZN  404 1_555 ? ? ? ? ? ? ? 2.495 ? ? 
metalc16 metalc ? ? B ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  401 A HOH 534 1_555 ? ? ? ? ? ? ? 1.986 ? ? 
metalc17 metalc ? ? C ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  402 A HOH 872 1_555 ? ? ? ? ? ? ? 2.576 ? ? 
metalc18 metalc ? ? C ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  402 A HOH 878 1_555 ? ? ? ? ? ? ? 2.535 ? ? 
metalc19 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  403 A HOH 551 4_454 ? ? ? ? ? ? ? 2.443 ? ? 
metalc20 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  403 A HOH 845 1_555 ? ? ? ? ? ? ? 2.479 ? ? 
metalc21 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  403 A HOH 921 4_454 ? ? ? ? ? ? ? 2.337 ? ? 
metalc22 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  404 A HOH 566 1_555 ? ? ? ? ? ? ? 2.544 ? ? 
metalc23 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  404 A HOH 638 1_555 ? ? ? ? ? ? ? 2.490 ? ? 
metalc24 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  404 A HOH 675 1_555 ? ? ? ? ? ? ? 2.581 ? ? 
metalc25 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  405 A HOH 544 1_555 ? ? ? ? ? ? ? 2.121 ? ? 
metalc26 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  405 A HOH 581 1_555 ? ? ? ? ? ? ? 2.142 ? ? 
metalc27 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  405 A HOH 773 1_555 ? ? ? ? ? ? ? 2.148 ? ? 
metalc28 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  405 A HOH 802 1_555 ? ? ? ? ? ? ? 2.099 ? ? 
metalc29 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? A ZN  405 A HOH 911 1_555 ? ? ? ? ? ? ? 2.109 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 4_454 OE2 ? A GLU 27  ? A GLU 27  ? 1_555 35.1  ? 
2  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 4_454 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 118.3 ? 
3  OE2 ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 4_454 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 98.9  ? 
4  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 544 ? 1_555 95.0  ? 
5  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 581 ? 1_555 90.7  ? 
6  O   ? J HOH .   ? A HOH 544 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 581 ? 1_555 90.6  ? 
7  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 773 ? 1_555 88.9  ? 
8  O   ? J HOH .   ? A HOH 544 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 773 ? 1_555 175.8 ? 
9  O   ? J HOH .   ? A HOH 581 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 773 ? 1_555 87.8  ? 
10 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 802 ? 1_555 92.7  ? 
11 O   ? J HOH .   ? A HOH 544 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 802 ? 1_555 89.5  ? 
12 O   ? J HOH .   ? A HOH 581 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 802 ? 1_555 176.6 ? 
13 O   ? J HOH .   ? A HOH 773 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 802 ? 1_555 91.8  ? 
14 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 911 ? 1_555 177.5 ? 
15 O   ? J HOH .   ? A HOH 544 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 911 ? 1_555 87.2  ? 
16 O   ? J HOH .   ? A HOH 581 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 911 ? 1_555 90.4  ? 
17 O   ? J HOH .   ? A HOH 773 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 911 ? 1_555 88.9  ? 
18 O   ? J HOH .   ? A HOH 802 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? J HOH .   ? A HOH 911 ? 1_555 86.2  ? 
19 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? A SER 307 ? A SER 307 ? 1_555 102.3 ? 
20 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 90.3  ? 
21 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 84.1  ? 
22 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 872 ? 1_555 89.7  ? 
23 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 872 ? 1_555 166.6 ? 
24 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 872 ? 1_555 102.2 ? 
25 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 878 ? 1_555 166.7 ? 
26 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 878 ? 1_555 91.0  ? 
27 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 878 ? 1_555 91.1  ? 
28 O   ? J HOH .   ? A HOH 872 ? 1_555 ZN ? C ZN . ? A ZN 402 ? 1_555 O   ? J HOH .   ? A HOH 878 ? 1_555 77.1  ? 
29 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 118.1 ? 
30 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 O   ? J HOH .   ? A HOH 534 ? 1_555 96.7  ? 
31 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 O   ? J HOH .   ? A HOH 534 ? 1_555 107.9 ? 
32 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 67.7  ? 
33 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 551 ? 4_454 92.0  ? 
34 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 551 ? 4_454 146.4 ? 
35 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 845 ? 1_555 89.9  ? 
36 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 845 ? 1_555 41.5  ? 
37 O   ? J HOH .   ? A HOH 551 ? 4_454 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 845 ? 1_555 171.3 ? 
38 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 921 ? 4_454 146.5 ? 
39 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 921 ? 4_454 129.2 ? 
40 O   ? J HOH .   ? A HOH 551 ? 4_454 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 921 ? 4_454 82.5  ? 
41 O   ? J HOH .   ? A HOH 845 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? J HOH .   ? A HOH 921 ? 4_454 91.3  ? 
42 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? A ALA 374 ? A ALA 374 ? 1_555 97.0  ? 
43 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 147.2 ? 
44 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 82.2  ? 
45 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 92.1  ? 
46 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 168.9 ? 
47 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 86.7  ? 
48 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 566 ? 1_555 73.6  ? 
49 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 566 ? 1_555 86.9  ? 
50 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 566 ? 1_555 73.6  ? 
51 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 566 ? 1_555 89.7  ? 
52 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 638 ? 1_555 139.7 ? 
53 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 638 ? 1_555 90.2  ? 
54 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 638 ? 1_555 73.0  ? 
55 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 638 ? 1_555 86.8  ? 
56 O   ? J HOH .   ? A HOH 566 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 638 ? 1_555 146.5 ? 
57 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 77.1  ? 
58 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 91.9  ? 
59 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 135.6 ? 
60 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 96.2  ? 
61 O   ? J HOH .   ? A HOH 566 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 150.4 ? 
62 O   ? J HOH .   ? A HOH 638 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? J HOH .   ? A HOH 675 ? 1_555 63.0  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 95  A . ? HIS 95  A THR 96  A ? THR 96  A 1 -1.00 
2 GLU 208 A . ? GLU 208 A PRO 209 A ? PRO 209 A 1 5.18  
3 TRP 241 A . ? TRP 241 A PRO 242 A ? PRO 242 A 1 -6.44 
4 TRP 273 A . ? TRP 273 A PRO 274 A ? PRO 274 A 1 -1.47 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA1 2 3  ? parallel      
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? parallel      
AA1 9 10 ? parallel      
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  HIS A 236 ? GLN A 238 ? HIS A 236 GLN A 238 
AA1 2  ASP A 260 ? SER A 269 ? ASP A 260 SER A 269 
AA1 3  ILE A 310 ? PHE A 315 ? ILE A 310 PHE A 315 
AA1 4  THR A 29  ? VAL A 34  ? THR A 29  VAL A 34  
AA1 5  SER A 54  ? ALA A 57  ? SER A 54  ALA A 57  
AA1 6  ASP A 91  ? VAL A 98  ? ASP A 91  VAL A 98  
AA1 7  TYR A 153 ? THR A 158 ? TYR A 153 THR A 158 
AA1 8  LYS A 197 ? ASP A 202 ? LYS A 197 ASP A 202 
AA1 9  GLY A 230 ? HIS A 233 ? GLY A 230 HIS A 233 
AA1 10 ASP A 260 ? SER A 269 ? ASP A 260 SER A 269 
AA2 1  VAL A 339 ? VAL A 340 ? VAL A 339 VAL A 340 
AA2 2  VAL A 331 ? TYR A 333 ? VAL A 331 TYR A 333 
AA2 3  LYS A 349 ? GLU A 351 ? LYS A 349 GLU A 351 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ILE A 237 ? N ILE A 237 O SER A 269 ? O SER A 269 
AA1 2 3  N ILE A 263 ? N ILE A 263 O THR A 314 ? O THR A 314 
AA1 3 4  O PHE A 315 ? O PHE A 315 N GLY A 31  ? N GLY A 31  
AA1 4 5  N VAL A 34  ? N VAL A 34  O VAL A 56  ? O VAL A 56  
AA1 5 6  N ILE A 55  ? N ILE A 55  O ARG A 93  ? O ARG A 93  
AA1 6 7  N PHE A 94  ? N PHE A 94  O ASP A 155 ? O ASP A 155 
AA1 7 8  N TRP A 154 ? N TRP A 154 O TYR A 199 ? O TYR A 199 
AA1 8 9  N MET A 200 ? N MET A 200 O GLY A 232 ? O GLY A 232 
AA1 9 10 N HIS A 233 ? N HIS A 233 O GLN A 262 ? O GLN A 262 
AA2 1 2  O VAL A 340 ? O VAL A 340 N TYR A 332 ? N TYR A 332 
AA2 2 3  N VAL A 331 ? N VAL A 331 O GLU A 351 ? O GLU A 351 
# 
_pdbx_entry_details.entry_id                   9FK8 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A HOH 515 ? ? O A HOH 687 ? ? 2.04 
2  1 O   A HOH 860 ? ? O A HOH 918 ? ? 2.12 
3  1 O   A HOH 752 ? ? O A HOH 860 ? ? 2.12 
4  1 ND2 A ASN 118 ? ? O A HOH 501 ? ? 2.13 
5  1 O   A HOH 515 ? ? O A HOH 793 ? ? 2.14 
6  1 O   A HOH 857 ? ? O A HOH 937 ? ? 2.15 
7  1 O   A HOH 901 ? ? O A HOH 940 ? ? 2.16 
8  1 O   A HOH 505 ? ? O A HOH 554 ? ? 2.17 
9  1 OE1 A GLU 137 ? ? O A HOH 502 ? ? 2.17 
10 1 NZ  A LYS 114 ? ? O A HOH 503 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     588 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     588 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_555 
_pdbx_validate_symm_contact.dist              2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 6   ? ? 84.34   114.71 
2 1 ASN A 59  ? ? -145.92 -34.96 
3 1 ILE A 318 ? ? -109.32 -62.72 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 511 ? J HOH . 
2 1 A HOH 532 ? J HOH . 
3 1 A HOH 609 ? J HOH . 
4 1 A HOH 825 ? J HOH . 
5 1 A HOH 934 ? J HOH . 
6 1 A HOH 955 ? J HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A LYS 1 ? A LYS 1 
2 1 Y 1 A ASN 2 ? A ASN 2 
3 1 Y 1 A ALA 3 ? A ALA 3 
4 1 Y 1 A ASP 4 ? A ASP 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
GLN N    N  N N 75  
GLN CA   C  N S 76  
GLN C    C  N N 77  
GLN O    O  N N 78  
GLN CB   C  N N 79  
GLN CG   C  N N 80  
GLN CD   C  N N 81  
GLN OE1  O  N N 82  
GLN NE2  N  N N 83  
GLN OXT  O  N N 84  
GLN H    H  N N 85  
GLN H2   H  N N 86  
GLN HA   H  N N 87  
GLN HB2  H  N N 88  
GLN HB3  H  N N 89  
GLN HG2  H  N N 90  
GLN HG3  H  N N 91  
GLN HE21 H  N N 92  
GLN HE22 H  N N 93  
GLN HXT  H  N N 94  
GLU N    N  N N 95  
GLU CA   C  N S 96  
GLU C    C  N N 97  
GLU O    O  N N 98  
GLU CB   C  N N 99  
GLU CG   C  N N 100 
GLU CD   C  N N 101 
GLU OE1  O  N N 102 
GLU OE2  O  N N 103 
GLU OXT  O  N N 104 
GLU H    H  N N 105 
GLU H2   H  N N 106 
GLU HA   H  N N 107 
GLU HB2  H  N N 108 
GLU HB3  H  N N 109 
GLU HG2  H  N N 110 
GLU HG3  H  N N 111 
GLU HE2  H  N N 112 
GLU HXT  H  N N 113 
GLY N    N  N N 114 
GLY CA   C  N N 115 
GLY C    C  N N 116 
GLY O    O  N N 117 
GLY OXT  O  N N 118 
GLY H    H  N N 119 
GLY H2   H  N N 120 
GLY HA2  H  N N 121 
GLY HA3  H  N N 122 
GLY HXT  H  N N 123 
HIS N    N  N N 124 
HIS CA   C  N S 125 
HIS C    C  N N 126 
HIS O    O  N N 127 
HIS CB   C  N N 128 
HIS CG   C  Y N 129 
HIS ND1  N  Y N 130 
HIS CD2  C  Y N 131 
HIS CE1  C  Y N 132 
HIS NE2  N  Y N 133 
HIS OXT  O  N N 134 
HIS H    H  N N 135 
HIS H2   H  N N 136 
HIS HA   H  N N 137 
HIS HB2  H  N N 138 
HIS HB3  H  N N 139 
HIS HD1  H  N N 140 
HIS HD2  H  N N 141 
HIS HE1  H  N N 142 
HIS HE2  H  N N 143 
HIS HXT  H  N N 144 
HOH O    O  N N 145 
HOH H1   H  N N 146 
HOH H2   H  N N 147 
ILE N    N  N N 148 
ILE CA   C  N S 149 
ILE C    C  N N 150 
ILE O    O  N N 151 
ILE CB   C  N S 152 
ILE CG1  C  N N 153 
ILE CG2  C  N N 154 
ILE CD1  C  N N 155 
ILE OXT  O  N N 156 
ILE H    H  N N 157 
ILE H2   H  N N 158 
ILE HA   H  N N 159 
ILE HB   H  N N 160 
ILE HG12 H  N N 161 
ILE HG13 H  N N 162 
ILE HG21 H  N N 163 
ILE HG22 H  N N 164 
ILE HG23 H  N N 165 
ILE HD11 H  N N 166 
ILE HD12 H  N N 167 
ILE HD13 H  N N 168 
ILE HXT  H  N N 169 
LEU N    N  N N 170 
LEU CA   C  N S 171 
LEU C    C  N N 172 
LEU O    O  N N 173 
LEU CB   C  N N 174 
LEU CG   C  N N 175 
LEU CD1  C  N N 176 
LEU CD2  C  N N 177 
LEU OXT  O  N N 178 
LEU H    H  N N 179 
LEU H2   H  N N 180 
LEU HA   H  N N 181 
LEU HB2  H  N N 182 
LEU HB3  H  N N 183 
LEU HG   H  N N 184 
LEU HD11 H  N N 185 
LEU HD12 H  N N 186 
LEU HD13 H  N N 187 
LEU HD21 H  N N 188 
LEU HD22 H  N N 189 
LEU HD23 H  N N 190 
LEU HXT  H  N N 191 
LYS N    N  N N 192 
LYS CA   C  N S 193 
LYS C    C  N N 194 
LYS O    O  N N 195 
LYS CB   C  N N 196 
LYS CG   C  N N 197 
LYS CD   C  N N 198 
LYS CE   C  N N 199 
LYS NZ   N  N N 200 
LYS OXT  O  N N 201 
LYS H    H  N N 202 
LYS H2   H  N N 203 
LYS HA   H  N N 204 
LYS HB2  H  N N 205 
LYS HB3  H  N N 206 
LYS HG2  H  N N 207 
LYS HG3  H  N N 208 
LYS HD2  H  N N 209 
LYS HD3  H  N N 210 
LYS HE2  H  N N 211 
LYS HE3  H  N N 212 
LYS HZ1  H  N N 213 
LYS HZ2  H  N N 214 
LYS HZ3  H  N N 215 
LYS HXT  H  N N 216 
MET N    N  N N 217 
MET CA   C  N S 218 
MET C    C  N N 219 
MET O    O  N N 220 
MET CB   C  N N 221 
MET CG   C  N N 222 
MET SD   S  N N 223 
MET CE   C  N N 224 
MET OXT  O  N N 225 
MET H    H  N N 226 
MET H2   H  N N 227 
MET HA   H  N N 228 
MET HB2  H  N N 229 
MET HB3  H  N N 230 
MET HG2  H  N N 231 
MET HG3  H  N N 232 
MET HE1  H  N N 233 
MET HE2  H  N N 234 
MET HE3  H  N N 235 
MET HXT  H  N N 236 
PHE N    N  N N 237 
PHE CA   C  N S 238 
PHE C    C  N N 239 
PHE O    O  N N 240 
PHE CB   C  N N 241 
PHE CG   C  Y N 242 
PHE CD1  C  Y N 243 
PHE CD2  C  Y N 244 
PHE CE1  C  Y N 245 
PHE CE2  C  Y N 246 
PHE CZ   C  Y N 247 
PHE OXT  O  N N 248 
PHE H    H  N N 249 
PHE H2   H  N N 250 
PHE HA   H  N N 251 
PHE HB2  H  N N 252 
PHE HB3  H  N N 253 
PHE HD1  H  N N 254 
PHE HD2  H  N N 255 
PHE HE1  H  N N 256 
PHE HE2  H  N N 257 
PHE HZ   H  N N 258 
PHE HXT  H  N N 259 
PRO N    N  N N 260 
PRO CA   C  N S 261 
PRO C    C  N N 262 
PRO O    O  N N 263 
PRO CB   C  N N 264 
PRO CG   C  N N 265 
PRO CD   C  N N 266 
PRO OXT  O  N N 267 
PRO H    H  N N 268 
PRO HA   H  N N 269 
PRO HB2  H  N N 270 
PRO HB3  H  N N 271 
PRO HG2  H  N N 272 
PRO HG3  H  N N 273 
PRO HD2  H  N N 274 
PRO HD3  H  N N 275 
PRO HXT  H  N N 276 
SER N    N  N N 277 
SER CA   C  N S 278 
SER C    C  N N 279 
SER O    O  N N 280 
SER CB   C  N N 281 
SER OG   O  N N 282 
SER OXT  O  N N 283 
SER H    H  N N 284 
SER H2   H  N N 285 
SER HA   H  N N 286 
SER HB2  H  N N 287 
SER HB3  H  N N 288 
SER HG   H  N N 289 
SER HXT  H  N N 290 
THR N    N  N N 291 
THR CA   C  N S 292 
THR C    C  N N 293 
THR O    O  N N 294 
THR CB   C  N R 295 
THR OG1  O  N N 296 
THR CG2  C  N N 297 
THR OXT  O  N N 298 
THR H    H  N N 299 
THR H2   H  N N 300 
THR HA   H  N N 301 
THR HB   H  N N 302 
THR HG1  H  N N 303 
THR HG21 H  N N 304 
THR HG22 H  N N 305 
THR HG23 H  N N 306 
THR HXT  H  N N 307 
TRP N    N  N N 308 
TRP CA   C  N S 309 
TRP C    C  N N 310 
TRP O    O  N N 311 
TRP CB   C  N N 312 
TRP CG   C  Y N 313 
TRP CD1  C  Y N 314 
TRP CD2  C  Y N 315 
TRP NE1  N  Y N 316 
TRP CE2  C  Y N 317 
TRP CE3  C  Y N 318 
TRP CZ2  C  Y N 319 
TRP CZ3  C  Y N 320 
TRP CH2  C  Y N 321 
TRP OXT  O  N N 322 
TRP H    H  N N 323 
TRP H2   H  N N 324 
TRP HA   H  N N 325 
TRP HB2  H  N N 326 
TRP HB3  H  N N 327 
TRP HD1  H  N N 328 
TRP HE1  H  N N 329 
TRP HE3  H  N N 330 
TRP HZ2  H  N N 331 
TRP HZ3  H  N N 332 
TRP HH2  H  N N 333 
TRP HXT  H  N N 334 
TYR N    N  N N 335 
TYR CA   C  N S 336 
TYR C    C  N N 337 
TYR O    O  N N 338 
TYR CB   C  N N 339 
TYR CG   C  Y N 340 
TYR CD1  C  Y N 341 
TYR CD2  C  Y N 342 
TYR CE1  C  Y N 343 
TYR CE2  C  Y N 344 
TYR CZ   C  Y N 345 
TYR OH   O  N N 346 
TYR OXT  O  N N 347 
TYR H    H  N N 348 
TYR H2   H  N N 349 
TYR HA   H  N N 350 
TYR HB2  H  N N 351 
TYR HB3  H  N N 352 
TYR HD1  H  N N 353 
TYR HD2  H  N N 354 
TYR HE1  H  N N 355 
TYR HE2  H  N N 356 
TYR HH   H  N N 357 
TYR HXT  H  N N 358 
VAL N    N  N N 359 
VAL CA   C  N S 360 
VAL C    C  N N 361 
VAL O    O  N N 362 
VAL CB   C  N N 363 
VAL CG1  C  N N 364 
VAL CG2  C  N N 365 
VAL OXT  O  N N 366 
VAL H    H  N N 367 
VAL H2   H  N N 368 
VAL HA   H  N N 369 
VAL HB   H  N N 370 
VAL HG11 H  N N 371 
VAL HG12 H  N N 372 
VAL HG13 H  N N 373 
VAL HG21 H  N N 374 
VAL HG22 H  N N 375 
VAL HG23 H  N N 376 
VAL HXT  H  N N 377 
ZN  ZN   ZN N N 378 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9FK1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FK8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011252 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003082 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016246 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009360 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 5   ? -4.11327  30.62558 -25.68831 1.000 32.22677 ? 5    SER A N   1 
ATOM   2    C  CA  . SER A 1 5   ? -3.98768  29.88524 -26.93150 1.000 42.10212 ? 5    SER A CA  1 
ATOM   3    C  C   . SER A 1 5   ? -4.71254  30.55471 -28.10152 1.000 55.48222 ? 5    SER A C   1 
ATOM   4    O  O   . SER A 1 5   ? -5.93487  30.42873 -28.24599 1.000 47.03635 ? 5    SER A O   1 
ATOM   5    C  CB  . SER A 1 5   ? -4.50733  28.46221 -26.76539 1.000 30.43299 ? 5    SER A CB  1 
ATOM   6    O  OG  . SER A 1 5   ? -5.06089  28.01811 -27.99088 1.000 41.76256 ? 5    SER A OG  1 
ATOM   7    N  N   . TYR A 1 6   ? -3.91815  31.26843 -28.91270 1.000 68.08818 ? 6    TYR A N   1 
ATOM   8    C  CA  . TYR A 1 6   ? -4.26952  31.79268 -30.23310 1.000 57.60984 ? 6    TYR A CA  1 
ATOM   9    C  C   . TYR A 1 6   ? -4.99487  33.12930 -30.15721 1.000 61.42424 ? 6    TYR A C   1 
ATOM   10   O  O   . TYR A 1 6   ? -6.11359  33.22234 -29.63589 1.000 54.25608 ? 6    TYR A O   1 
ATOM   11   C  CB  . TYR A 1 6   ? -5.09666  30.77876 -31.03277 1.000 51.52899 ? 6    TYR A CB  1 
ATOM   12   C  CG  . TYR A 1 6   ? -4.27181  29.61798 -31.54647 1.000 58.61878 ? 6    TYR A CG  1 
ATOM   13   C  CD1 . TYR A 1 6   ? -3.56426  28.79503 -30.67503 1.000 60.86239 ? 6    TYR A CD1 1 
ATOM   14   C  CD2 . TYR A 1 6   ? -4.18698  29.35355 -32.90000 1.000 55.85507 ? 6    TYR A CD2 1 
ATOM   15   C  CE1 . TYR A 1 6   ? -2.80614  27.73601 -31.14381 1.000 64.62244 ? 6    TYR A CE1 1 
ATOM   16   C  CE2 . TYR A 1 6   ? -3.43406  28.30336 -33.38374 1.000 59.72995 ? 6    TYR A CE2 1 
ATOM   17   C  CZ  . TYR A 1 6   ? -2.74374  27.49435 -32.50106 1.000 68.59172 ? 6    TYR A CZ  1 
ATOM   18   O  OH  . TYR A 1 6   ? -1.98840  26.44310 -32.97536 1.000 69.50523 ? 6    TYR A OH  1 
ATOM   19   N  N   . ALA A 1 7   ? -4.34145  34.17105 -30.67822 1.000 62.39113 ? 7    ALA A N   1 
ATOM   20   C  CA  . ALA A 1 7   ? -4.93778  35.48581 -30.85860 1.000 57.97160 ? 7    ALA A CA  1 
ATOM   21   C  C   . ALA A 1 7   ? -5.30201  35.76747 -32.31133 1.000 59.27037 ? 7    ALA A C   1 
ATOM   22   O  O   . ALA A 1 7   ? -6.01537  36.74400 -32.58073 1.000 63.02509 ? 7    ALA A O   1 
ATOM   23   C  CB  . ALA A 1 7   ? -3.98804  36.57703 -30.34334 1.000 58.85182 ? 7    ALA A CB  1 
ATOM   24   N  N   . LYS A 1 8   ? -4.83655  34.93776 -33.25107 1.000 55.42906 ? 8    LYS A N   1 
ATOM   25   C  CA  . LYS A 1 8   ? -5.26154  35.09337 -34.63721 1.000 58.51113 ? 8    LYS A CA  1 
ATOM   26   C  C   . LYS A 1 8   ? -6.69212  34.60854 -34.85185 1.000 41.64580 ? 8    LYS A C   1 
ATOM   27   O  O   . LYS A 1 8   ? -7.32736  35.00276 -35.83573 1.000 45.85954 ? 8    LYS A O   1 
ATOM   28   C  CB  . LYS A 1 8   ? -4.29910  34.35440 -35.57159 1.000 54.74535 ? 8    LYS A CB  1 
ATOM   29   C  CG  . LYS A 1 8   ? -4.12848  32.87932 -35.25541 1.000 61.49779 ? 8    LYS A CG  1 
ATOM   30   C  CD  . LYS A 1 8   ? -4.88445  32.00890 -36.25515 1.000 58.99402 ? 8    LYS A CD  1 
ATOM   31   C  CE  . LYS A 1 8   ? -5.14483  30.64178 -35.66716 1.000 55.13508 ? 8    LYS A CE  1 
ATOM   32   N  NZ  . LYS A 1 8   ? -5.36139  29.55686 -36.65543 1.000 54.69184 ? 8    LYS A NZ  1 
ATOM   33   N  N   . LYS A 1 9   ? -7.20668  33.76429 -33.96527 1.000 33.46488 ? 9    LYS A N   1 
ATOM   34   C  CA  . LYS A 1 9   ? -8.59790  33.36937 -34.06004 1.000 26.45067 ? 9    LYS A CA  1 
ATOM   35   C  C   . LYS A 1 9   ? -9.49238  34.56061 -33.71383 1.000 21.22934 ? 9    LYS A C   1 
ATOM   36   O  O   . LYS A 1 9   ? -9.21158  35.29901 -32.76251 1.000 15.95939 ? 9    LYS A O   1 
ATOM   37   C  CB  . LYS A 1 9   ? -8.88834  32.19041 -33.13613 1.000 29.14645 ? 9    LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 9   ? -8.19336  30.88964 -33.54242 1.000 32.20947 ? 9    LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 9   ? -8.57003  30.46849 -34.95927 1.000 35.74960 ? 9    LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 9   ? -10.05593 30.20112 -35.13348 1.000 36.86708 ? 9    LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 9   ? -10.38937 29.80016 -36.53620 1.000 46.95765 ? 9    LYS A NZ  1 
ATOM   42   N  N   . PRO A 1 10  ? -10.56753 34.77102 -34.45584 1.000 18.06660 ? 10   PRO A N   1 
ATOM   43   C  CA  . PRO A 1 10  ? -11.25577 36.06130 -34.41731 1.000 13.31796 ? 10   PRO A CA  1 
ATOM   44   C  C   . PRO A 1 10  ? -12.20611 36.20852 -33.23649 1.000 12.08655 ? 10   PRO A C   1 
ATOM   45   O  O   . PRO A 1 10  ? -12.69855 35.23944 -32.64865 1.000 11.60066 ? 10   PRO A O   1 
ATOM   46   C  CB  . PRO A 1 10  ? -12.02309 36.07916 -35.74236 1.000 13.87780 ? 10   PRO A CB  1 
ATOM   47   C  CG  . PRO A 1 10  ? -12.31149 34.63223 -36.00774 1.000 17.61111 ? 10   PRO A CG  1 
ATOM   48   C  CD  . PRO A 1 10  ? -11.14981 33.85106 -35.45295 1.000 18.49841 ? 10   PRO A CD  1 
ATOM   49   N  N   . HIS A 1 11  ? -12.45454 37.47644 -32.90891 1.000 8.85984  ? 11   HIS A N   1 
ATOM   50   C  CA  . HIS A 1 11  ? -13.36176 37.91199 -31.84319 1.000 11.33607 ? 11   HIS A CA  1 
ATOM   51   C  C   . HIS A 1 11  ? -14.80051 37.94565 -32.36870 1.000 11.47791 ? 11   HIS A C   1 
ATOM   52   O  O   . HIS A 1 11  ? -15.45356 38.98399 -32.41681 1.000 12.04651 ? 11   HIS A O   1 
ATOM   53   C  CB  . HIS A 1 11  ? -12.89509 39.28552 -31.35993 1.000 11.91579 ? 11   HIS A CB  1 
ATOM   54   C  CG  . HIS A 1 11  ? -13.59093 39.81694 -30.14394 1.000 9.04040  ? 11   HIS A CG  1 
ATOM   55   N  ND1 . HIS A 1 11  ? -13.68551 39.11463 -28.96253 1.000 8.28287  ? 11   HIS A ND1 1 
ATOM   56   C  CD2 . HIS A 1 11  ? -14.15749 41.02631 -29.90806 1.000 8.08185  ? 11   HIS A CD2 1 
ATOM   57   C  CE1 . HIS A 1 11  ? -14.30471 39.85533 -28.06107 1.000 9.88107  ? 11   HIS A CE1 1 
ATOM   58   N  NE2 . HIS A 1 11  ? -14.59075 41.02440 -28.60702 1.000 10.87367 ? 11   HIS A NE2 1 
ATOM   59   N  N   . ILE A 1 12  ? -15.28384 36.77930 -32.79213 1.000 10.51616 ? 12   ILE A N   1 
ATOM   60   C  CA  . ILE A 1 12  ? -16.61531 36.68868 -33.38756 1.000 10.77773 ? 12   ILE A CA  1 
ATOM   61   C  C   . ILE A 1 12  ? -17.68472 36.62602 -32.29839 1.000 9.76117  ? 12   ILE A C   1 
ATOM   62   O  O   . ILE A 1 12  ? -17.42015 36.30377 -31.13844 1.000 10.67638 ? 12   ILE A O   1 
ATOM   63   C  CB  . ILE A 1 12  ? -16.72544 35.46860 -34.32201 1.000 15.65323 ? 12   ILE A CB  1 
ATOM   64   C  CG1 . ILE A 1 12  ? -16.43324 34.17712 -33.53924 1.000 12.34633 ? 12   ILE A CG1 1 
ATOM   65   C  CG2 . ILE A 1 12  ? -15.80190 35.61801 -35.53476 1.000 13.03688 ? 12   ILE A CG2 1 
ATOM   66   C  CD1 . ILE A 1 12  ? -16.82401 32.89427 -34.28775 1.000 12.52486 ? 12   ILE A CD1 1 
ATOM   67   N  N   . SER A 1 13  ? -18.91874 36.91417 -32.69779 1.000 8.49380  ? 13   SER A N   1 
ATOM   68   C  CA  . SER A 1 13  ? -20.04676 36.77867 -31.78321 1.000 15.97877 ? 13   SER A CA  1 
ATOM   69   C  C   . SER A 1 13  ? -20.16407 35.33330 -31.31288 1.000 14.97009 ? 13   SER A C   1 
ATOM   70   O  O   . SER A 1 13  ? -20.06590 34.38801 -32.11033 1.000 10.91824 ? 13   SER A O   1 
ATOM   71   C  CB  . SER A 1 13  ? -21.34073 37.23269 -32.46873 1.000 12.42743 ? 13   SER A CB  1 
ATOM   72   O  OG  . SER A 1 13  ? -22.48443 36.72388 -31.79547 1.000 14.57070 ? 13   SER A OG  1 
ATOM   73   N  N   . ALA A 1 14  ? -20.36270 35.15700 -30.00332 1.000 11.28819 ? 14   ALA A N   1 
ATOM   74   C  CA  . ALA A 1 14  ? -20.54295 33.81901 -29.44885 1.000 11.47907 ? 14   ALA A CA  1 
ATOM   75   C  C   . ALA A 1 14  ? -21.78049 33.12407 -30.00711 1.000 11.49244 ? 14   ALA A C   1 
ATOM   76   O  O   . ALA A 1 14  ? -21.84070 31.89454 -30.00328 1.000 11.63656 ? 14   ALA A O   1 
ATOM   77   C  CB  . ALA A 1 14  ? -20.62873 33.88241 -27.92335 1.000 9.36172  ? 14   ALA A CB  1 
ATOM   78   N  N   . LEU A 1 15  ? -22.77657 33.88028 -30.46731 1.000 16.53383 ? 15   LEU A N   1 
ATOM   79   C  CA  . LEU A 1 15  ? -23.94253 33.26401 -31.09528 1.000 17.58672 ? 15   LEU A CA  1 
ATOM   80   C  C   . LEU A 1 15  ? -23.61335 32.64773 -32.44745 1.000 13.61719 ? 15   LEU A C   1 
ATOM   81   O  O   . LEU A 1 15  ? -24.43798 31.91567 -32.99794 1.000 20.75128 ? 15   LEU A O   1 
ATOM   82   C  CB  . LEU A 1 15  ? -25.06568 34.29551 -31.23828 1.000 18.52344 ? 15   LEU A CB  1 
ATOM   83   C  CG  . LEU A 1 15  ? -25.73978 34.72854 -29.93718 1.000 20.57296 ? 15   LEU A CG  1 
ATOM   84   C  CD1 . LEU A 1 15  ? -25.86343 33.55045 -28.95896 1.000 19.61892 ? 15   LEU A CD1 1 
ATOM   85   C  CD2 . LEU A 1 15  ? -25.00637 35.88181 -29.28740 1.000 27.79147 ? 15   LEU A CD2 1 
ATOM   86   N  N   . ASN A 1 16  ? -22.42149 32.90283 -32.97836 1.000 19.53140 ? 16   ASN A N   1 
ATOM   87   C  CA  . ASN A 1 16  ? -21.96064 32.32863 -34.23556 1.000 25.05040 ? 16   ASN A CA  1 
ATOM   88   C  C   . ASN A 1 16  ? -20.85455 31.31012 -34.02948 1.000 26.25707 ? 16   ASN A C   1 
ATOM   89   O  O   . ASN A 1 16  ? -20.27376 30.82625 -35.00954 1.000 22.67690 ? 16   ASN A O   1 
ATOM   90   C  CB  . ASN A 1 16  ? -21.46498 33.43558 -35.17292 1.000 22.98898 ? 16   ASN A CB  1 
ATOM   91   C  CG  . ASN A 1 16  ? -22.59530 34.28192 -35.69587 1.000 30.98651 ? 16   ASN A CG  1 
ATOM   92   O  OD1 . ASN A 1 16  ? -23.73494 33.81196 -35.76788 1.000 31.78306 ? 16   ASN A OD1 1 
ATOM   93   N  ND2 . ASN A 1 16  ? -22.30122 35.53832 -36.05345 1.000 26.82414 ? 16   ASN A ND2 1 
ATOM   94   N  N   . ALA A 1 17  ? -20.52849 31.00091 -32.78830 1.000 17.27370 ? 17   ALA A N   1 
ATOM   95   C  CA  . ALA A 1 17  ? -19.36578 30.18266 -32.52987 1.000 12.75982 ? 17   ALA A CA  1 
ATOM   96   C  C   . ALA A 1 17  ? -19.76738 28.73047 -32.28858 1.000 10.08656 ? 17   ALA A C   1 
ATOM   97   O  O   . ALA A 1 17  ? -20.90365 28.44167 -31.89645 1.000 11.50722 ? 17   ALA A O   1 
ATOM   98   C  CB  . ALA A 1 17  ? -18.59744 30.73289 -31.32447 1.000 11.37231 ? 17   ALA A CB  1 
ATOM   99   N  N   . PRO A 1 18  ? -18.86145 27.79074 -32.57422 1.000 11.83986 ? 18   PRO A N   1 
ATOM   100  C  CA  . PRO A 1 18  ? -19.08979 26.39015 -32.19864 1.000 9.97061  ? 18   PRO A CA  1 
ATOM   101  C  C   . PRO A 1 18  ? -19.56154 26.25750 -30.75147 1.000 9.88081  ? 18   PRO A C   1 
ATOM   102  O  O   . PRO A 1 18  ? -19.05218 26.92687 -29.84706 1.000 8.11526  ? 18   PRO A O   1 
ATOM   103  C  CB  . PRO A 1 18  ? -17.71438 25.74783 -32.40562 1.000 11.05081 ? 18   PRO A CB  1 
ATOM   104  C  CG  . PRO A 1 18  ? -17.10498 26.53308 -33.55959 1.000 12.98597 ? 18   PRO A CG  1 
ATOM   105  C  CD  . PRO A 1 18  ? -17.63553 27.96307 -33.38486 1.000 11.40258 ? 18   PRO A CD  1 
ATOM   106  N  N   . GLN A 1 19  ? -20.52554 25.36349 -30.54439 1.000 8.17552  ? 19   GLN A N   1 
ATOM   107  C  CA  . GLN A 1 19  ? -21.20034 25.23131 -29.25601 1.000 11.23343 ? 19   GLN A CA  1 
ATOM   108  C  C   . GLN A 1 19  ? -20.29318 24.57886 -28.21827 1.000 10.93555 ? 19   GLN A C   1 
ATOM   109  O  O   . GLN A 1 19  ? -19.79787 23.46012 -28.41515 1.000 8.78022  ? 19   GLN A O   1 
ATOM   110  C  CB  . GLN A 1 19  ? -22.48336 24.41216 -29.41391 1.000 7.38239  ? 19   GLN A CB  1 
ATOM   111  C  CG  . GLN A 1 19  ? -23.49122 25.02038 -30.41148 1.000 11.67855 ? 19   GLN A CG  1 
ATOM   112  C  CD  . GLN A 1 19  ? -23.29616 24.54133 -31.84924 1.000 17.80540 ? 19   GLN A CD  1 
ATOM   113  O  OE1 . GLN A 1 19  ? -22.18957 24.20320 -32.26377 1.000 13.46341 ? 19   GLN A OE1 1 
ATOM   114  N  NE2 . GLN A 1 19  ? -24.38241 24.51798 -32.61557 1.000 15.86788 ? 19   GLN A NE2 1 
ATOM   115  N  N   . LEU A 1 20  ? -20.13236 25.26318 -27.08454 1.000 9.02393  ? 20   LEU A N   1 
ATOM   116  C  CA  . LEU A 1 20  ? -19.25620 24.77895 -26.01745 1.000 11.35020 ? 20   LEU A CA  1 
ATOM   117  C  C   . LEU A 1 20  ? -19.73628 23.44552 -25.44129 1.000 9.97667  ? 20   LEU A C   1 
ATOM   118  O  O   . LEU A 1 20  ? -18.93472 22.53337 -25.21341 1.000 8.94321  ? 20   LEU A O   1 
ATOM   119  C  CB  . LEU A 1 20  ? -19.15898 25.84150 -24.91952 1.000 10.68686 ? 20   LEU A CB  1 
ATOM   120  C  CG  . LEU A 1 20  ? -18.00717 25.74148 -23.93030 1.000 14.96563 ? 20   LEU A CG  1 
ATOM   121  C  CD1 . LEU A 1 20  ? -16.68633 25.59689 -24.66994 1.000 12.85381 ? 20   LEU A CD1 1 
ATOM   122  C  CD2 . LEU A 1 20  ? -17.97823 26.96287 -23.01588 1.000 14.22716 ? 20   LEU A CD2 1 
ATOM   123  N  N   . ASP A 1 21  ? -21.03707 23.31251 -25.16889 1.000 8.77558  ? 21   ASP A N   1 
ATOM   124  C  CA  . ASP A 1 21  ? -21.51279 22.05877 -24.57651 1.000 8.30062  ? 21   ASP A CA  1 
ATOM   125  C  C   . ASP A 1 21  ? -21.31916 20.87331 -25.52876 1.000 10.18071 ? 21   ASP A C   1 
ATOM   126  O  O   . ASP A 1 21  ? -21.00242 19.75495 -25.09077 1.000 8.40196  ? 21   ASP A O   1 
ATOM   127  C  CB  . ASP A 1 21  ? -22.98176 22.18707 -24.14154 1.000 8.97960  ? 21   ASP A CB  1 
ATOM   128  C  CG  . ASP A 1 21  ? -23.93847 22.43923 -25.30543 1.000 10.16575 ? 21   ASP A CG  1 
ATOM   129  O  OD1 . ASP A 1 21  ? -23.52434 23.04004 -26.31150 1.000 7.59522  ? 21   ASP A OD1 1 
ATOM   130  O  OD2 . ASP A 1 21  ? -25.12421 22.04388 -25.20005 1.000 10.37631 ? 21   ASP A OD2 1 
ATOM   131  N  N   . GLN A 1 22  ? -21.49206 21.09831 -26.83392 1.000 8.44097  ? 22   GLN A N   1 
ATOM   132  C  CA  . GLN A 1 22  ? -21.32825 20.01453 -27.79906 1.000 10.48779 ? 22   GLN A CA  1 
ATOM   133  C  C   . GLN A 1 22  ? -19.87560 19.57137 -27.89652 1.000 10.91605 ? 22   GLN A C   1 
ATOM   134  O  O   . GLN A 1 22  ? -19.60271 18.38363 -28.10845 1.000 10.55331 ? 22   GLN A O   1 
ATOM   135  C  CB  . GLN A 1 22  ? -21.86461 20.44671 -29.16737 1.000 7.34016  ? 22   GLN A CB  1 
ATOM   136  C  CG  . GLN A 1 22  ? -23.39743 20.44331 -29.20269 1.000 11.38505 ? 22   GLN A CG  1 
ATOM   137  C  CD  . GLN A 1 22  ? -23.98264 20.96704 -30.49618 1.000 16.49889 ? 22   GLN A CD  1 
ATOM   138  O  OE1 . GLN A 1 22  ? -23.44616 20.72378 -31.57654 1.000 19.33617 ? 22   GLN A OE1 1 
ATOM   139  N  NE2 . GLN A 1 22  ? -25.08882 21.70123 -30.39210 1.000 13.64557 ? 22   GLN A NE2 1 
ATOM   140  N  N   . ARG A 1 23  ? -18.94027 20.50265 -27.72246 1.000 8.87073  ? 23   ARG A N   1 
ATOM   141  C  CA  . ARG A 1 23  ? -17.52441 20.15100 -27.71133 1.000 12.99884 ? 23   ARG A CA  1 
ATOM   142  C  C   . ARG A 1 23  ? -17.20266 19.19120 -26.57832 1.000 10.74077 ? 23   ARG A C   1 
ATOM   143  O  O   . ARG A 1 23  ? -16.36732 18.29581 -26.74257 1.000 12.30523 ? 23   ARG A O   1 
ATOM   144  C  CB  . ARG A 1 23  ? -16.66982 21.42113 -27.60639 1.000 7.59025  ? 23   ARG A CB  1 
ATOM   145  C  CG  . ARG A 1 23  ? -15.19634 21.22352 -27.15942 1.000 7.95935  ? 23   ARG A CG  1 
ATOM   146  C  CD  . ARG A 1 23  ? -14.36322 20.41591 -28.15637 1.000 10.70717 ? 23   ARG A CD  1 
ATOM   147  N  NE  . ARG A 1 23  ? -12.97797 20.29918 -27.71441 1.000 10.27542 ? 23   ARG A NE  1 
ATOM   148  C  CZ  . ARG A 1 23  ? -12.55683 19.42224 -26.80904 1.000 12.62860 ? 23   ARG A CZ  1 
ATOM   149  N  NH1 . ARG A 1 23  ? -13.41944 18.57928 -26.25556 1.000 11.25340 ? 23   ARG A NH1 1 
ATOM   150  N  NH2 . ARG A 1 23  ? -11.27380 19.37864 -26.46140 1.000 12.02270 ? 23   ARG A NH2 1 
ATOM   151  N  N   . TYR A 1 24  ? -17.87633 19.33037 -25.44075 1.000 8.35083  ? 24   TYR A N   1 
ATOM   152  C  CA  . TYR A 1 24  ? -17.54292 18.54264 -24.26279 1.000 7.56229  ? 24   TYR A CA  1 
ATOM   153  C  C   . TYR A 1 24  ? -18.59225 17.48640 -23.91754 1.000 8.06864  ? 24   TYR A C   1 
ATOM   154  O  O   . TYR A 1 24  ? -18.51485 16.90110 -22.84226 1.000 8.38433  ? 24   TYR A O   1 
ATOM   155  C  CB  . TYR A 1 24  ? -17.30920 19.48484 -23.07639 1.000 8.60494  ? 24   TYR A CB  1 
ATOM   156  C  CG  . TYR A 1 24  ? -15.98607 20.21238 -23.20326 1.000 9.45126  ? 24   TYR A CG  1 
ATOM   157  C  CD1 . TYR A 1 24  ? -14.78514 19.56206 -22.91557 1.000 8.05684  ? 24   TYR A CD1 1 
ATOM   158  C  CD2 . TYR A 1 24  ? -15.93312 21.52610 -23.64681 1.000 6.89834  ? 24   TYR A CD2 1 
ATOM   159  C  CE1 . TYR A 1 24  ? -13.55698 20.21087 -23.05186 1.000 10.55350 ? 24   TYR A CE1 1 
ATOM   160  C  CE2 . TYR A 1 24  ? -14.71086 22.18857 -23.78738 1.000 7.41251  ? 24   TYR A CE2 1 
ATOM   161  C  CZ  . TYR A 1 24  ? -13.52507 21.52211 -23.50060 1.000 10.79160 ? 24   TYR A CZ  1 
ATOM   162  O  OH  . TYR A 1 24  ? -12.30624 22.16777 -23.64744 1.000 7.97223  ? 24   TYR A OH  1 
ATOM   163  N  N   . LYS A 1 25  ? -19.53198 17.18668 -24.82369 1.000 9.07841  ? 25   LYS A N   1 
ATOM   164  C  CA  . LYS A 1 25  ? -20.74662 16.46669 -24.41998 1.000 15.23017 ? 25   LYS A CA  1 
ATOM   165  C  C   . LYS A 1 25  ? -20.48242 15.03664 -23.94761 1.000 14.16899 ? 25   LYS A C   1 
ATOM   166  O  O   . LYS A 1 25  ? -21.29243 14.49005 -23.19687 1.000 14.31493 ? 25   LYS A O   1 
ATOM   167  C  CB  . LYS A 1 25  ? -21.76233 16.45067 -25.55694 1.000 13.51245 ? 25   LYS A CB  1 
ATOM   168  C  CG  . LYS A 1 25  ? -21.32494 15.71525 -26.82063 1.000 16.68434 ? 25   LYS A CG  1 
ATOM   169  C  CD  . LYS A 1 25  ? -22.51235 15.64781 -27.78638 1.000 22.23755 ? 25   LYS A CD  1 
ATOM   170  C  CE  . LYS A 1 25  ? -22.09976 15.37976 -29.21627 1.000 18.21803 ? 25   LYS A CE  1 
ATOM   171  N  NZ  . LYS A 1 25  ? -20.91848 16.19097 -29.60526 1.000 20.33225 ? 25   LYS A NZ  1 
ATOM   172  N  N   . ASN A 1 26  ? -19.38724 14.40381 -24.37082 1.000 11.18233 ? 26   ASN A N   1 
ATOM   173  C  CA  . ASN A 1 26  ? -19.07217 13.07526 -23.84967 1.000 11.32146 ? 26   ASN A CA  1 
ATOM   174  C  C   . ASN A 1 26  ? -18.20643 13.12193 -22.59927 1.000 10.73009 ? 26   ASN A C   1 
ATOM   175  O  O   . ASN A 1 26  ? -18.04050 12.09470 -21.92905 1.000 11.33793 ? 26   ASN A O   1 
ATOM   176  C  CB  . ASN A 1 26  ? -18.37446 12.23836 -24.92962 1.000 10.98988 ? 26   ASN A CB  1 
ATOM   177  C  CG  . ASN A 1 26  ? -19.22264 12.10217 -26.18229 1.000 16.92319 ? 26   ASN A CG  1 
ATOM   178  O  OD1 . ASN A 1 26  ? -20.43993 11.88688 -26.10198 1.000 15.05123 ? 26   ASN A OD1 1 
ATOM   179  N  ND2 . ASN A 1 26  ? -18.59665 12.25640 -27.34413 1.000 14.44885 ? 26   ASN A ND2 1 
ATOM   180  N  N   . GLU A 1 27  ? -17.65568 14.28426 -22.27258 1.000 8.40609  ? 27   GLU A N   1 
ATOM   181  C  CA  . GLU A 1 27  ? -16.75792 14.43440 -21.13979 1.000 9.24376  ? 27   GLU A CA  1 
ATOM   182  C  C   . GLU A 1 27  ? -17.47959 14.92160 -19.88804 1.000 11.24278 ? 27   GLU A C   1 
ATOM   183  O  O   . GLU A 1 27  ? -17.23699 14.39543 -18.80800 1.000 13.23939 ? 27   GLU A O   1 
ATOM   184  C  CB  . GLU A 1 27  ? -15.62466 15.39280 -21.50582 1.000 8.17775  ? 27   GLU A CB  1 
ATOM   185  C  CG  . GLU A 1 27  ? -15.29451 15.44016 -23.00805 1.000 9.50984  ? 27   GLU A CG  1 
ATOM   186  C  CD  . GLU A 1 27  ? -14.92437 14.07455 -23.58651 1.000 10.78371 ? 27   GLU A CD  1 
ATOM   187  O  OE1 . GLU A 1 27  ? -14.36249 13.23450 -22.86518 1.000 9.71000  ? 27   GLU A OE1 1 
ATOM   188  O  OE2 . GLU A 1 27  ? -15.20633 13.84443 -24.77081 1.000 12.44705 ? 27   GLU A OE2 1 
ATOM   189  N  N   . PHE A 1 28  ? -18.35271 15.92433 -20.00749 1.000 9.92053  ? 28   PHE A N   1 
ATOM   190  C  CA  . PHE A 1 28  ? -19.10828 16.46413 -18.87638 1.000 10.63672 ? 28   PHE A CA  1 
ATOM   191  C  C   . PHE A 1 28  ? -20.05299 17.51735 -19.43223 1.000 9.26402  ? 28   PHE A C   1 
ATOM   192  O  O   . PHE A 1 28  ? -19.81144 18.07147 -20.50654 1.000 9.45220  ? 28   PHE A O   1 
ATOM   193  C  CB  . PHE A 1 28  ? -18.20075 17.08695 -17.78234 1.000 7.71840  ? 28   PHE A CB  1 
ATOM   194  C  CG  . PHE A 1 28  ? -16.93130 17.71758 -18.31958 1.000 9.19976  ? 28   PHE A CG  1 
ATOM   195  C  CD1 . PHE A 1 28  ? -16.97545 18.91386 -19.02796 1.000 7.95134  ? 28   PHE A CD1 1 
ATOM   196  C  CD2 . PHE A 1 28  ? -15.69470 17.11557 -18.10801 1.000 9.59954  ? 28   PHE A CD2 1 
ATOM   197  C  CE1 . PHE A 1 28  ? -15.80537 19.49847 -19.52740 1.000 8.40449  ? 28   PHE A CE1 1 
ATOM   198  C  CE2 . PHE A 1 28  ? -14.52649 17.68408 -18.60287 1.000 9.64380  ? 28   PHE A CE2 1 
ATOM   199  C  CZ  . PHE A 1 28  ? -14.58457 18.89107 -19.31355 1.000 8.59457  ? 28   PHE A CZ  1 
ATOM   200  N  N   . THR A 1 29  ? -21.12474 17.79267 -18.69560 1.000 6.28729  ? 29   THR A N   1 
ATOM   201  C  CA  . THR A 1 29  ? -21.99210 18.88997 -19.08176 1.000 6.80070  ? 29   THR A CA  1 
ATOM   202  C  C   . THR A 1 29  ? -21.27538 20.22487 -18.85154 1.000 7.94129  ? 29   THR A C   1 
ATOM   203  O  O   . THR A 1 29  ? -20.29088 20.31977 -18.11249 1.000 5.59921  ? 29   THR A O   1 
ATOM   204  C  CB  . THR A 1 29  ? -23.29983 18.85966 -18.28848 1.000 9.93249  ? 29   THR A CB  1 
ATOM   205  O  OG1 . THR A 1 29  ? -22.98851 18.87492 -16.89285 1.000 8.13674  ? 29   THR A OG1 1 
ATOM   206  C  CG2 . THR A 1 29  ? -24.13253 17.60288 -18.62952 1.000 11.09022 ? 29   THR A CG2 1 
ATOM   207  N  N   . ILE A 1 30  ? -21.77679 21.26104 -19.51713 1.000 8.63027  ? 30   ILE A N   1 
ATOM   208  C  CA  . ILE A 1 30  ? -21.24040 22.61176 -19.41284 1.000 7.99480  ? 30   ILE A CA  1 
ATOM   209  C  C   . ILE A 1 30  ? -22.37991 23.48621 -18.92292 1.000 7.15231  ? 30   ILE A C   1 
ATOM   210  O  O   . ILE A 1 30  ? -23.41740 23.58747 -19.59560 1.000 7.67354  ? 30   ILE A O   1 
ATOM   211  C  CB  . ILE A 1 30  ? -20.68725 23.12594 -20.75747 1.000 6.24882  ? 30   ILE A CB  1 
ATOM   212  C  CG1 . ILE A 1 30  ? -19.55836 22.22863 -21.28186 1.000 8.54698  ? 30   ILE A CG1 1 
ATOM   213  C  CG2 . ILE A 1 30  ? -20.21044 24.58573 -20.63532 1.000 6.19420  ? 30   ILE A CG2 1 
ATOM   214  C  CD1 . ILE A 1 30  ? -18.27953 22.25355 -20.42936 1.000 8.55884  ? 30   ILE A CD1 1 
ATOM   215  N  N   . GLY A 1 31  ? -22.20531 24.12095 -17.75571 1.000 6.20406  ? 31   GLY A N   1 
ATOM   216  C  CA  . GLY A 1 31  ? -23.26268 24.86669 -17.11919 1.000 6.77511  ? 31   GLY A CA  1 
ATOM   217  C  C   . GLY A 1 31  ? -22.94436 26.34865 -16.92364 1.000 7.32762  ? 31   GLY A C   1 
ATOM   218  O  O   . GLY A 1 31  ? -21.79565 26.78078 -16.99569 1.000 6.93787  ? 31   GLY A O   1 
ATOM   219  N  N   . ALA A 1 32  ? -24.00682 27.11720 -16.65406 1.000 7.06949  ? 32   ALA A N   1 
ATOM   220  C  CA  . ALA A 1 32  ? -23.93856 28.54087 -16.36033 1.000 8.87307  ? 32   ALA A CA  1 
ATOM   221  C  C   . ALA A 1 32  ? -24.83446 28.84732 -15.16921 1.000 8.17914  ? 32   ALA A C   1 
ATOM   222  O  O   . ALA A 1 32  ? -25.92343 28.28196 -15.04922 1.000 6.11449  ? 32   ALA A O   1 
ATOM   223  C  CB  . ALA A 1 32  ? -24.40359 29.38898 -17.56434 1.000 5.98924  ? 32   ALA A CB  1 
ATOM   224  N  N   . ALA A 1 33  ? -24.38817 29.76768 -14.30934 1.000 7.89519  ? 33   ALA A N   1 
ATOM   225  C  CA  . ALA A 1 33  ? -25.20501 30.28278 -13.21327 1.000 6.30127  ? 33   ALA A CA  1 
ATOM   226  C  C   . ALA A 1 33  ? -25.96027 31.51993 -13.68393 1.000 8.10316  ? 33   ALA A C   1 
ATOM   227  O  O   . ALA A 1 33  ? -25.40302 32.35762 -14.39814 1.000 8.19188  ? 33   ALA A O   1 
ATOM   228  C  CB  . ALA A 1 33  ? -24.33192 30.62806 -12.00390 1.000 6.04248  ? 33   ALA A CB  1 
ATOM   229  N  N   . VAL A 1 34  ? -27.23883 31.63412 -13.29857 1.000 6.54241  ? 34   VAL A N   1 
ATOM   230  C  CA  . VAL A 1 34  ? -28.10644 32.65824 -13.87376 1.000 7.11667  ? 34   VAL A CA  1 
ATOM   231  C  C   . VAL A 1 34  ? -29.02266 33.28195 -12.82445 1.000 8.17804  ? 34   VAL A C   1 
ATOM   232  O  O   . VAL A 1 34  ? -29.29755 32.70582 -11.76474 1.000 8.43353  ? 34   VAL A O   1 
ATOM   233  C  CB  . VAL A 1 34  ? -28.97481 32.11076 -15.03521 1.000 9.00710  ? 34   VAL A CB  1 
ATOM   234  C  CG1 . VAL A 1 34  ? -28.10847 31.41313 -16.08862 1.000 5.75583  ? 34   VAL A CG1 1 
ATOM   235  C  CG2 . VAL A 1 34  ? -30.04982 31.16626 -14.48622 1.000 8.03901  ? 34   VAL A CG2 1 
ATOM   236  N  N   . GLU A 1 35  ? -29.50098 34.48814 -13.15292 1.000 6.20727  ? 35   GLU A N   1 
ATOM   237  C  CA  . GLU A 1 35  ? -30.58067 35.20132 -12.49123 1.000 8.91207  ? 35   GLU A CA  1 
ATOM   238  C  C   . GLU A 1 35  ? -31.82606 35.18500 -13.37648 1.000 9.30181  ? 35   GLU A C   1 
ATOM   239  O  O   . GLU A 1 35  ? -31.71702 35.17556 -14.60867 1.000 8.93481  ? 35   GLU A O   1 
ATOM   240  C  CB  . GLU A 1 35  ? -30.19617 36.65682 -12.18366 1.000 10.68248 ? 35   GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 35  ? -29.01305 36.80125 -11.24009 1.000 10.43948 ? 35   GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 35  ? -29.44089 36.79287 -9.77729  1.000 13.34588 ? 35   GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 35  ? -30.47811 36.17034 -9.45185  1.000 10.02439 ? 35   GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 35  ? -28.74745 37.42049 -8.95617  1.000 12.14551 ? 35   GLU A OE2 1 
ATOM   245  N  N   . PRO A 1 36  ? -33.02023 35.15623 -12.78682 1.000 12.58948 ? 36   PRO A N   1 
ATOM   246  C  CA  . PRO A 1 36  ? -34.23418 35.09682 -13.62088 1.000 12.15611 ? 36   PRO A CA  1 
ATOM   247  C  C   . PRO A 1 36  ? -34.31197 36.18258 -14.68010 1.000 13.59155 ? 36   PRO A C   1 
ATOM   248  O  O   . PRO A 1 36  ? -34.77986 35.89654 -15.78568 1.000 13.75705 ? 36   PRO A O   1 
ATOM   249  C  CB  . PRO A 1 36  ? -35.35851 35.20180 -12.58496 1.000 17.93736 ? 36   PRO A CB  1 
ATOM   250  C  CG  . PRO A 1 36  ? -34.77077 34.48126 -11.38709 1.000 15.31712 ? 36   PRO A CG  1 
ATOM   251  C  CD  . PRO A 1 36  ? -33.32246 34.91977 -11.36078 1.000 10.27064 ? 36   PRO A CD  1 
ATOM   252  N  N   . TYR A 1 37  ? -33.83253 37.40092 -14.40083 1.000 12.63527 ? 37   TYR A N   1 
ATOM   253  C  CA  . TYR A 1 37  ? -33.95169 38.46592 -15.39305 1.000 15.99663 ? 37   TYR A CA  1 
ATOM   254  C  C   . TYR A 1 37  ? -33.18162 38.13393 -16.66554 1.000 16.03937 ? 37   TYR A C   1 
ATOM   255  O  O   . TYR A 1 37  ? -33.57433 38.56690 -17.75236 1.000 15.45242 ? 37   TYR A O   1 
ATOM   256  C  CB  . TYR A 1 37  ? -33.49491 39.81188 -14.80526 1.000 16.38459 ? 37   TYR A CB  1 
ATOM   257  C  CG  . TYR A 1 37  ? -31.99036 40.03912 -14.80263 1.000 15.55855 ? 37   TYR A CG  1 
ATOM   258  C  CD1 . TYR A 1 37  ? -31.32491 40.45413 -15.94783 1.000 17.22581 ? 37   TYR A CD1 1 
ATOM   259  C  CD2 . TYR A 1 37  ? -31.24824 39.84955 -13.64818 1.000 19.22750 ? 37   TYR A CD2 1 
ATOM   260  C  CE1 . TYR A 1 37  ? -29.96825 40.64936 -15.94999 1.000 20.42580 ? 37   TYR A CE1 1 
ATOM   261  C  CE2 . TYR A 1 37  ? -29.88895 40.05820 -13.63455 1.000 18.44304 ? 37   TYR A CE2 1 
ATOM   262  C  CZ  . TYR A 1 37  ? -29.25152 40.44919 -14.78711 1.000 19.66223 ? 37   TYR A CZ  1 
ATOM   263  O  OH  . TYR A 1 37  ? -27.88925 40.65228 -14.79048 1.000 27.29759 ? 37   TYR A OH  1 
ATOM   264  N  N   . GLN A 1 38  ? -32.10178 37.35199 -16.56473 1.000 14.68229 ? 38   GLN A N   1 
ATOM   265  C  CA  . GLN A 1 38  ? -31.36354 36.99375 -17.77445 1.000 12.78991 ? 38   GLN A CA  1 
ATOM   266  C  C   . GLN A 1 38  ? -32.18632 36.10301 -18.70069 1.000 14.56294 ? 38   GLN A C   1 
ATOM   267  O  O   . GLN A 1 38  ? -31.92808 36.07483 -19.91059 1.000 15.51416 ? 38   GLN A O   1 
ATOM   268  C  CB  . GLN A 1 38  ? -30.03138 36.32495 -17.40474 1.000 9.94137  ? 38   GLN A CB  1 
ATOM   269  C  CG  . GLN A 1 38  ? -29.07798 37.23608 -16.60530 1.000 8.39360  ? 38   GLN A CG  1 
ATOM   270  C  CD  . GLN A 1 38  ? -27.90136 36.46899 -16.00013 1.000 10.13183 ? 38   GLN A CD  1 
ATOM   271  O  OE1 . GLN A 1 38  ? -28.07787 35.39227 -15.44392 1.000 11.92882 ? 38   GLN A OE1 1 
ATOM   272  N  NE2 . GLN A 1 38  ? -26.70732 37.02449 -16.10479 1.000 7.22721  ? 38   GLN A NE2 1 
ATOM   273  N  N   . LEU A 1 39  ? -33.19486 35.40423 -18.17282 1.000 14.83767 ? 39   LEU A N   1 
ATOM   274  C  CA  . LEU A 1 39  ? -34.09226 34.61939 -19.02278 1.000 17.73704 ? 39   LEU A CA  1 
ATOM   275  C  C   . LEU A 1 39  ? -35.06074 35.49063 -19.81545 1.000 19.82103 ? 39   LEU A C   1 
ATOM   276  O  O   . LEU A 1 39  ? -35.81671 34.96148 -20.64088 1.000 17.14910 ? 39   LEU A O   1 
ATOM   277  C  CB  . LEU A 1 39  ? -34.88390 33.61923 -18.17430 1.000 12.54667 ? 39   LEU A CB  1 
ATOM   278  C  CG  . LEU A 1 39  ? -34.00934 32.76894 -17.26052 1.000 13.33799 ? 39   LEU A CG  1 
ATOM   279  C  CD1 . LEU A 1 39  ? -34.84584 31.78433 -16.43353 1.000 12.53549 ? 39   LEU A CD1 1 
ATOM   280  C  CD2 . LEU A 1 39  ? -32.91774 32.03851 -18.08224 1.000 11.09153 ? 39   LEU A CD2 1 
ATOM   281  N  N   . GLN A 1 40  ? -35.07025 36.79882 -19.56403 1.000 15.29998 ? 40   GLN A N   1 
ATOM   282  C  CA  . GLN A 1 40  ? -35.89748 37.74650 -20.29482 1.000 22.73268 ? 40   GLN A CA  1 
ATOM   283  C  C   . GLN A 1 40  ? -35.06311 38.58972 -21.24109 1.000 22.20259 ? 40   GLN A C   1 
ATOM   284  O  O   . GLN A 1 40  ? -35.58074 39.52817 -21.84634 1.000 23.46356 ? 40   GLN A O   1 
ATOM   285  C  CB  . GLN A 1 40  ? -36.66799 38.64907 -19.32481 1.000 21.97384 ? 40   GLN A CB  1 
ATOM   286  C  CG  . GLN A 1 40  ? -37.60167 37.90304 -18.36697 1.000 23.13961 ? 40   GLN A CG  1 
ATOM   287  C  CD  . GLN A 1 40  ? -38.57962 36.97959 -19.08649 1.000 38.02032 ? 40   GLN A CD  1 
ATOM   288  O  OE1 . GLN A 1 40  ? -38.67708 35.78801 -18.77331 1.000 40.69345 ? 40   GLN A OE1 1 
ATOM   289  N  NE2 . GLN A 1 40  ? -39.31277 37.52696 -20.05361 1.000 39.33830 ? 40   GLN A NE2 1 
ATOM   290  N  N   . ASN A 1 41  ? -33.78164 38.27412 -21.37122 1.000 17.99477 ? 41   ASN A N   1 
ATOM   291  C  CA  . ASN A 1 41  ? -32.85122 39.01167 -22.20505 1.000 23.13111 ? 41   ASN A CA  1 
ATOM   292  C  C   . ASN A 1 41  ? -32.47506 38.14556 -23.39672 1.000 21.44898 ? 41   ASN A C   1 
ATOM   293  O  O   . ASN A 1 41  ? -32.00787 37.01782 -23.21691 1.000 15.56024 ? 41   ASN A O   1 
ATOM   294  C  CB  . ASN A 1 41  ? -31.60529 39.38378 -21.40049 1.000 23.58245 ? 41   ASN A CB  1 
ATOM   295  C  CG  . ASN A 1 41  ? -30.56705 40.04780 -22.24185 1.000 30.75880 ? 41   ASN A CG  1 
ATOM   296  O  OD1 . ASN A 1 41  ? -29.68531 39.38850 -22.80061 1.000 27.67664 ? 41   ASN A OD1 1 
ATOM   297  N  ND2 . ASN A 1 41  ? -30.66949 41.36757 -22.36706 1.000 37.31639 ? 41   ASN A ND2 1 
ATOM   298  N  N   . GLU A 1 42  ? -32.65953 38.67848 -24.60791 1.000 19.82785 ? 42   GLU A N   1 
ATOM   299  C  CA  . GLU A 1 42  ? -32.52057 37.84617 -25.79604 1.000 20.02925 ? 42   GLU A CA  1 
ATOM   300  C  C   . GLU A 1 42  ? -31.11733 37.26214 -25.91469 1.000 15.55293 ? 42   GLU A C   1 
ATOM   301  O  O   . GLU A 1 42  ? -30.96139 36.08376 -26.25167 1.000 14.59198 ? 42   GLU A O   1 
ATOM   302  C  CB  . GLU A 1 42  ? -32.87387 38.64124 -27.05154 1.000 22.94754 ? 42   GLU A CB  1 
ATOM   303  C  CG  . GLU A 1 42  ? -32.70452 37.83097 -28.33553 1.000 31.39426 ? 42   GLU A CG  1 
ATOM   304  C  CD  . GLU A 1 42  ? -33.07124 38.60972 -29.59683 1.000 51.95656 ? 42   GLU A CD  1 
ATOM   305  O  OE1 . GLU A 1 42  ? -32.46841 39.67874 -29.84234 1.000 49.82539 ? 42   GLU A OE1 1 
ATOM   306  O  OE2 . GLU A 1 42  ? -33.95931 38.14528 -30.34630 1.000 55.51886 ? 42   GLU A OE2 1 
ATOM   307  N  N   . LYS A 1 43  ? -30.08202 38.06890 -25.66209 1.000 14.08595 ? 43   LYS A N   1 
ATOM   308  C  CA  . LYS A 1 43  ? -28.71134 37.58075 -25.81901 1.000 17.68425 ? 43   LYS A CA  1 
ATOM   309  C  C   . LYS A 1 43  ? -28.38953 36.47950 -24.81606 1.000 12.66262 ? 43   LYS A C   1 
ATOM   310  O  O   . LYS A 1 43  ? -27.78371 35.46329 -25.17988 1.000 10.71412 ? 43   LYS A O   1 
ATOM   311  C  CB  . LYS A 1 43  ? -27.70427 38.72886 -25.68084 1.000 16.62907 ? 43   LYS A CB  1 
ATOM   312  C  CG  . LYS A 1 43  ? -27.61732 39.62065 -26.92499 1.000 27.46194 ? 43   LYS A CG  1 
ATOM   313  C  CD  . LYS A 1 43  ? -26.33729 39.34078 -27.73438 1.000 34.16612 ? 43   LYS A CD  1 
ATOM   314  C  CE  . LYS A 1 43  ? -26.24650 40.23155 -28.96926 1.000 34.52103 ? 43   LYS A CE  1 
ATOM   315  N  NZ  . LYS A 1 43  ? -26.63906 41.64297 -28.65297 1.000 46.29414 ? 43   LYS A NZ  1 
ATOM   316  N  N   . ASP A 1 44  ? -28.77553 36.66663 -23.54781 1.000 13.88771 ? 44   ASP A N   1 
ATOM   317  C  CA  . ASP A 1 44  ? -28.52125 35.63766 -22.54157 1.000 13.39905 ? 44   ASP A CA  1 
ATOM   318  C  C   . ASP A 1 44  ? -29.28697 34.35775 -22.86081 1.000 10.64404 ? 44   ASP A C   1 
ATOM   319  O  O   . ASP A 1 44  ? -28.74094 33.25410 -22.75442 1.000 12.08469 ? 44   ASP A O   1 
ATOM   320  C  CB  . ASP A 1 44  ? -28.89524 36.16036 -21.15221 1.000 16.23149 ? 44   ASP A CB  1 
ATOM   321  C  CG  . ASP A 1 44  ? -27.90240 37.17708 -20.63023 1.000 14.65262 ? 44   ASP A CG  1 
ATOM   322  O  OD1 . ASP A 1 44  ? -26.71442 37.09420 -21.00290 1.000 9.61007  ? 44   ASP A OD1 1 
ATOM   323  O  OD2 . ASP A 1 44  ? -28.30504 38.05732 -19.84378 1.000 12.67850 ? 44   ASP A OD2 1 
ATOM   324  N  N   . VAL A 1 45  ? -30.54880 34.48555 -23.25975 1.000 9.06333  ? 45   VAL A N   1 
ATOM   325  C  CA  . VAL A 1 45  ? -31.33143 33.31794 -23.66123 1.000 11.41065 ? 45   VAL A CA  1 
ATOM   326  C  C   . VAL A 1 45  ? -30.65019 32.59338 -24.82133 1.000 10.79269 ? 45   VAL A C   1 
ATOM   327  O  O   . VAL A 1 45  ? -30.48621 31.36826 -24.80788 1.000 10.35900 ? 45   VAL A O   1 
ATOM   328  C  CB  . VAL A 1 45  ? -32.77050 33.74332 -24.00851 1.000 13.15117 ? 45   VAL A CB  1 
ATOM   329  C  CG1 . VAL A 1 45  ? -33.51522 32.64052 -24.77922 1.000 10.37374 ? 45   VAL A CG1 1 
ATOM   330  C  CG2 . VAL A 1 45  ? -33.52334 34.13277 -22.72662 1.000 13.53232 ? 45   VAL A CG2 1 
ATOM   331  N  N   . GLN A 1 46  ? -30.22443 33.33929 -25.83585 1.000 12.34849 ? 46   GLN A N   1 
ATOM   332  C  CA  . GLN A 1 46  ? -29.55496 32.70370 -26.96704 1.000 14.02393 ? 46   GLN A CA  1 
ATOM   333  C  C   . GLN A 1 46  ? -28.23112 32.06612 -26.54308 1.000 10.06943 ? 46   GLN A C   1 
ATOM   334  O  O   . GLN A 1 46  ? -27.87194 30.98463 -27.02491 1.000 8.10807  ? 46   GLN A O   1 
ATOM   335  C  CB  . GLN A 1 46  ? -29.35247 33.72459 -28.09035 1.000 13.98963 ? 46   GLN A CB  1 
ATOM   336  C  CG  . GLN A 1 46  ? -30.65775 34.07210 -28.82792 1.000 22.17840 ? 46   GLN A CG  1 
ATOM   337  C  CD  . GLN A 1 46  ? -31.54360 32.84208 -29.10969 1.000 31.77380 ? 46   GLN A CD  1 
ATOM   338  O  OE1 . GLN A 1 46  ? -31.10792 31.87606 -29.74700 1.000 33.18440 ? 46   GLN A OE1 1 
ATOM   339  N  NE2 . GLN A 1 46  ? -32.79308 32.88270 -28.63563 1.000 30.30587 ? 46   GLN A NE2 1 
ATOM   340  N  N   . MET A 1 47  ? -27.50474 32.71212 -25.62869 1.000 8.29604  ? 47   MET A N   1 
ATOM   341  C  CA  . MET A 1 47  ? -26.27190 32.13083 -25.10783 1.000 9.73800  ? 47   MET A CA  1 
ATOM   342  C  C   . MET A 1 47  ? -26.54081 30.80172 -24.40342 1.000 10.87622 ? 47   MET A C   1 
ATOM   343  O  O   . MET A 1 47  ? -25.82572 29.81488 -24.61384 1.000 7.91737  ? 47   MET A O   1 
ATOM   344  C  CB  . MET A 1 47  ? -25.59533 33.12138 -24.15386 1.000 9.10969  ? 47   MET A CB  1 
ATOM   345  C  CG  . MET A 1 47  ? -24.88583 34.29043 -24.84631 1.000 9.19980  ? 47   MET A CG  1 
ATOM   346  S  SD  . MET A 1 47  ? -23.45454 33.77362 -25.83449 1.000 10.32743 ? 47   MET A SD  1 
ATOM   347  C  CE  . MET A 1 47  ? -22.29665 33.30239 -24.54509 1.000 7.06233  ? 47   MET A CE  1 
ATOM   348  N  N   . LEU A 1 48  ? -27.56635 30.76106 -23.54518 1.000 8.44933  ? 48   LEU A N   1 
ATOM   349  C  CA  . LEU A 1 48  ? -27.85826 29.53273 -22.80606 1.000 8.29790  ? 48   LEU A CA  1 
ATOM   350  C  C   . LEU A 1 48  ? -28.29348 28.40485 -23.74235 1.000 8.47943  ? 48   LEU A C   1 
ATOM   351  O  O   . LEU A 1 48  ? -27.86457 27.25036 -23.59031 1.000 9.02940  ? 48   LEU A O   1 
ATOM   352  C  CB  . LEU A 1 48  ? -28.93799 29.81623 -21.75290 1.000 7.33588  ? 48   LEU A CB  1 
ATOM   353  C  CG  . LEU A 1 48  ? -28.49651 30.72163 -20.59040 1.000 9.07078  ? 48   LEU A CG  1 
ATOM   354  C  CD1 . LEU A 1 48  ? -29.69936 31.29203 -19.85218 1.000 6.53328  ? 48   LEU A CD1 1 
ATOM   355  C  CD2 . LEU A 1 48  ? -27.57427 29.97646 -19.61597 1.000 5.96243  ? 48   LEU A CD2 1 
ATOM   356  N  N   . LYS A 1 49  ? -29.15910 28.71911 -24.70664 1.000 7.64195  ? 49   LYS A N   1 
ATOM   357  C  CA  . LYS A 1 49  ? -29.58554 27.72332 -25.68713 1.000 11.79239 ? 49   LYS A CA  1 
ATOM   358  C  C   . LYS A 1 49  ? -28.41458 27.22372 -26.52523 1.000 9.36520  ? 49   LYS A C   1 
ATOM   359  O  O   . LYS A 1 49  ? -28.35299 26.03920 -26.85919 1.000 10.98260 ? 49   LYS A O   1 
ATOM   360  C  CB  . LYS A 1 49  ? -30.65426 28.30958 -26.60334 1.000 10.64978 ? 49   LYS A CB  1 
ATOM   361  C  CG  . LYS A 1 49  ? -32.00980 28.52993 -25.94721 1.000 11.23000 ? 49   LYS A CG  1 
ATOM   362  C  CD  . LYS A 1 49  ? -33.02286 29.08111 -26.96342 1.000 13.32200 ? 49   LYS A CD  1 
ATOM   363  C  CE  . LYS A 1 49  ? -34.44344 29.07451 -26.38637 1.000 16.67889 ? 49   LYS A CE  1 
ATOM   364  N  NZ  . LYS A 1 49  ? -35.27716 30.12204 -27.02273 1.000 26.64659 ? 49   LYS A NZ  1 
ATOM   365  N  N   . ARG A 1 50  ? -27.47216 28.10924 -26.86953 1.000 8.34813  ? 50   ARG A N   1 
ATOM   366  C  CA  . ARG A 1 50  ? -26.40761 27.72647 -27.79632 1.000 11.60702 ? 50   ARG A CA  1 
ATOM   367  C  C   . ARG A 1 50  ? -25.29732 26.92321 -27.12856 1.000 11.92236 ? 50   ARG A C   1 
ATOM   368  O  O   . ARG A 1 50  ? -24.81701 25.94277 -27.70786 1.000 12.56838 ? 50   ARG A O   1 
ATOM   369  C  CB  . ARG A 1 50  ? -25.78085 28.95412 -28.46958 1.000 10.40291 ? 50   ARG A CB  1 
ATOM   370  C  CG  . ARG A 1 50  ? -24.70795 28.54382 -29.50689 1.000 12.96180 ? 50   ARG A CG  1 
ATOM   371  C  CD  . ARG A 1 50  ? -24.52652 29.55256 -30.62378 1.000 17.11919 ? 50   ARG A CD  1 
ATOM   372  N  NE  . ARG A 1 50  ? -23.61320 29.07674 -31.66517 1.000 19.69218 ? 50   ARG A NE  1 
ATOM   373  C  CZ  . ARG A 1 50  ? -23.98160 28.37847 -32.73927 1.000 21.78620 ? 50   ARG A CZ  1 
ATOM   374  N  NH1 . ARG A 1 50  ? -25.25251 28.05397 -32.92853 1.000 18.34616 ? 50   ARG A NH1 1 
ATOM   375  N  NH2 . ARG A 1 50  ? -23.07362 28.00705 -33.63560 1.000 17.36655 ? 50   ARG A NH2 1 
ATOM   376  N  N   . HIS A 1 51  ? -24.84806 27.32659 -25.93504 1.000 7.26771  ? 51   HIS A N   1 
ATOM   377  C  CA  . HIS A 1 51  ? -23.57516 26.82661 -25.42081 1.000 7.68992  ? 51   HIS A CA  1 
ATOM   378  C  C   . HIS A 1 51  ? -23.66457 25.94309 -24.18572 1.000 8.71757  ? 51   HIS A C   1 
ATOM   379  O  O   . HIS A 1 51  ? -22.66797 25.29556 -23.84912 1.000 8.82493  ? 51   HIS A O   1 
ATOM   380  C  CB  . HIS A 1 51  ? -22.64137 27.99926 -25.10455 1.000 7.31544  ? 51   HIS A CB  1 
ATOM   381  C  CG  . HIS A 1 51  ? -22.09817 28.66829 -26.32593 1.000 10.80610 ? 51   HIS A CG  1 
ATOM   382  N  ND1 . HIS A 1 51  ? -21.17016 28.06897 -27.15351 1.000 10.71889 ? 51   HIS A ND1 1 
ATOM   383  C  CD2 . HIS A 1 51  ? -22.36657 29.87687 -26.87172 1.000 8.12948  ? 51   HIS A CD2 1 
ATOM   384  C  CE1 . HIS A 1 51  ? -20.88041 28.88750 -28.14923 1.000 12.56430 ? 51   HIS A CE1 1 
ATOM   385  N  NE2 . HIS A 1 51  ? -21.59682 29.98871 -28.00450 1.000 13.11653 ? 51   HIS A NE2 1 
ATOM   386  N  N   . PHE A 1 52  ? -24.80196 25.89392 -23.50013 1.000 8.06785  ? 52   PHE A N   1 
ATOM   387  C  CA  . PHE A 1 52  ? -24.87352 25.29701 -22.17868 1.000 7.75512  ? 52   PHE A CA  1 
ATOM   388  C  C   . PHE A 1 52  ? -25.94298 24.21466 -22.13232 1.000 9.29960  ? 52   PHE A C   1 
ATOM   389  O  O   . PHE A 1 52  ? -27.00486 24.34554 -22.75065 1.000 8.69654  ? 52   PHE A O   1 
ATOM   390  C  CB  . PHE A 1 52  ? -25.16501 26.37623 -21.11611 1.000 9.74600  ? 52   PHE A CB  1 
ATOM   391  C  CG  . PHE A 1 52  ? -24.07552 27.41315 -20.99701 1.000 7.51802  ? 52   PHE A CG  1 
ATOM   392  C  CD1 . PHE A 1 52  ? -22.95493 27.16893 -20.22060 1.000 5.78490  ? 52   PHE A CD1 1 
ATOM   393  C  CD2 . PHE A 1 52  ? -24.18080 28.63212 -21.65694 1.000 7.19141  ? 52   PHE A CD2 1 
ATOM   394  C  CE1 . PHE A 1 52  ? -21.93939 28.12961 -20.11209 1.000 7.86916  ? 52   PHE A CE1 1 
ATOM   395  C  CE2 . PHE A 1 52  ? -23.18373 29.59175 -21.56059 1.000 7.24327  ? 52   PHE A CE2 1 
ATOM   396  C  CZ  . PHE A 1 52  ? -22.05640 29.34187 -20.78569 1.000 9.19287  ? 52   PHE A CZ  1 
ATOM   397  N  N   . ASN A 1 53  ? -25.67045 23.14494 -21.38108 1.000 6.84997  ? 53   ASN A N   1 
ATOM   398  C  CA  . ASN A 1 53  ? -26.67811 22.10532 -21.18620 1.000 9.76787  ? 53   ASN A CA  1 
ATOM   399  C  C   . ASN A 1 53  ? -26.90631 21.81931 -19.70624 1.000 9.75401  ? 53   ASN A C   1 
ATOM   400  O  O   . ASN A 1 53  ? -27.42581 20.75642 -19.36014 1.000 8.01066  ? 53   ASN A O   1 
ATOM   401  C  CB  . ASN A 1 53  ? -26.30113 20.81734 -21.93724 1.000 9.21601  ? 53   ASN A CB  1 
ATOM   402  C  CG  . ASN A 1 53  ? -24.90205 20.32731 -21.60290 1.000 10.32326 ? 53   ASN A CG  1 
ATOM   403  O  OD1 . ASN A 1 53  ? -24.24107 20.87364 -20.72353 1.000 9.85295  ? 53   ASN A OD1 1 
ATOM   404  N  ND2 . ASN A 1 53  ? -24.44565 19.27986 -22.30253 1.000 8.17433  ? 53   ASN A ND2 1 
ATOM   405  N  N   . SER A 1 54  ? -26.50711 22.74581 -18.83328 1.000 8.64655  ? 54   SER A N   1 
ATOM   406  C  CA  . SER A 1 54  ? -26.72802 22.65347 -17.39804 1.000 6.94451  ? 54   SER A CA  1 
ATOM   407  C  C   . SER A 1 54  ? -26.89857 24.06856 -16.86779 1.000 8.00937  ? 54   SER A C   1 
ATOM   408  O  O   . SER A 1 54  ? -26.34836 25.02260 -17.42997 1.000 6.77430  ? 54   SER A O   1 
ATOM   409  C  CB  . SER A 1 54  ? -25.56514 21.93089 -16.69077 1.000 7.71591  ? 54   SER A CB  1 
ATOM   410  O  OG  . SER A 1 54  ? -25.82579 21.73975 -15.30384 1.000 9.52787  ? 54   SER A OG  1 
ATOM   411  N  N   . ILE A 1 55  ? -27.65276 24.20599 -15.77662 1.000 7.75276  ? 55   ILE A N   1 
ATOM   412  C  CA  . ILE A 1 55  ? -27.98497 25.52399 -15.24704 1.000 7.05885  ? 55   ILE A CA  1 
ATOM   413  C  C   . ILE A 1 55  ? -28.06360 25.45419 -13.72240 1.000 7.94290  ? 55   ILE A C   1 
ATOM   414  O  O   . ILE A 1 55  ? -28.32362 24.39954 -13.13942 1.000 10.42648 ? 55   ILE A O   1 
ATOM   415  C  CB  . ILE A 1 55  ? -29.31093 26.04837 -15.85548 1.000 9.66291  ? 55   ILE A CB  1 
ATOM   416  C  CG1 . ILE A 1 55  ? -29.36093 27.57807 -15.79008 1.000 8.15048  ? 55   ILE A CG1 1 
ATOM   417  C  CG2 . ILE A 1 55  ? -30.52473 25.44404 -15.12547 1.000 6.53870  ? 55   ILE A CG2 1 
ATOM   418  C  CD1 . ILE A 1 55  ? -30.40808 28.20234 -16.72122 1.000 9.05980  ? 55   ILE A CD1 1 
ATOM   419  N  N   . VAL A 1 56  ? -27.81167 26.59674 -13.08426 1.000 7.87045  ? 56   VAL A N   1 
ATOM   420  C  CA  . VAL A 1 56  ? -27.86721 26.74998 -11.63506 1.000 6.66102  ? 56   VAL A CA  1 
ATOM   421  C  C   . VAL A 1 56  ? -28.27318 28.19332 -11.36329 1.000 8.83757  ? 56   VAL A C   1 
ATOM   422  O  O   . VAL A 1 56  ? -28.03016 29.09160 -12.18004 1.000 9.26495  ? 56   VAL A O   1 
ATOM   423  C  CB  . VAL A 1 56  ? -26.50725 26.38513 -10.97193 1.000 10.03414 ? 56   VAL A CB  1 
ATOM   424  C  CG1 . VAL A 1 56  ? -25.40975 27.33599 -11.43241 1.000 5.13241  ? 56   VAL A CG1 1 
ATOM   425  C  CG2 . VAL A 1 56  ? -26.59216 26.36943 -9.43994  1.000 6.12119  ? 56   VAL A CG2 1 
ATOM   426  N  N   . ALA A 1 57  ? -28.92195 28.42015 -10.22431 1.000 8.72361  ? 57   ALA A N   1 
ATOM   427  C  CA  . ALA A 1 57  ? -29.30125 29.77116 -9.82820  1.000 6.96530  ? 57   ALA A CA  1 
ATOM   428  C  C   . ALA A 1 57  ? -28.15428 30.44344 -9.08304  1.000 7.42571  ? 57   ALA A C   1 
ATOM   429  O  O   . ALA A 1 57  ? -27.65004 29.90373 -8.09292  1.000 8.83414  ? 57   ALA A O   1 
ATOM   430  C  CB  . ALA A 1 57  ? -30.55574 29.75065 -8.94541  1.000 7.76476  ? 57   ALA A CB  1 
ATOM   431  N  N   . GLU A 1 58  ? -27.75856 31.62952 -9.55106  1.000 7.33647  ? 58   GLU A N   1 
ATOM   432  C  CA  . GLU A 1 58  ? -26.80786 32.44576 -8.80108  1.000 10.82253 ? 58   GLU A CA  1 
ATOM   433  C  C   . GLU A 1 58  ? -27.28137 32.68994 -7.37438  1.000 13.52199 ? 58   GLU A C   1 
ATOM   434  O  O   . GLU A 1 58  ? -26.47382 32.68289 -6.43548  1.000 10.15376 ? 58   GLU A O   1 
ATOM   435  C  CB  . GLU A 1 58  ? -26.60908 33.80009 -9.48242  1.000 8.72828  ? 58   GLU A CB  1 
ATOM   436  C  CG  . GLU A 1 58  ? -25.53115 33.90306 -10.54235 1.000 11.45241 ? 58   GLU A CG  1 
ATOM   437  C  CD  . GLU A 1 58  ? -25.27709 35.35750 -10.92074 1.000 12.04640 ? 58   GLU A CD  1 
ATOM   438  O  OE1 . GLU A 1 58  ? -25.93248 36.22887 -10.30855 1.000 16.53998 ? 58   GLU A OE1 1 
ATOM   439  O  OE2 . GLU A 1 58  ? -24.45716 35.63399 -11.82759 1.000 13.88410 ? 58   GLU A OE2 1 
ATOM   440  N  N   . ASN A 1 59  ? -28.58406 32.95174 -7.19419  1.000 7.64005  ? 59   ASN A N   1 
ATOM   441  C  CA  . ASN A 1 59  ? -29.06131 33.45697 -5.90933  1.000 9.01461  ? 59   ASN A CA  1 
ATOM   442  C  C   . ASN A 1 59  ? -30.45530 32.97379 -5.51826  1.000 10.68127 ? 59   ASN A C   1 
ATOM   443  O  O   . ASN A 1 59  ? -30.71912 32.77913 -4.32885  1.000 10.74073 ? 59   ASN A O   1 
ATOM   444  C  CB  . ASN A 1 59  ? -29.05742 34.99335 -5.90571  1.000 10.67697 ? 59   ASN A CB  1 
ATOM   445  C  CG  . ASN A 1 59  ? -27.66387 35.57859 -5.71671  1.000 13.06629 ? 59   ASN A CG  1 
ATOM   446  O  OD1 . ASN A 1 59  ? -26.99879 35.34105 -4.70055  1.000 9.88125  ? 59   ASN A OD1 1 
ATOM   447  N  ND2 . ASN A 1 59  ? -27.22425 36.35842 -6.68988  1.000 11.05067 ? 59   ASN A ND2 1 
ATOM   448  N  N   . VAL A 1 60  ? -31.37536 32.79486 -6.47433  1.000 7.98568  ? 60   VAL A N   1 
ATOM   449  C  CA  . VAL A 1 60  ? -32.77499 32.65437 -6.06043  1.000 9.53767  ? 60   VAL A CA  1 
ATOM   450  C  C   . VAL A 1 60  ? -33.10675 31.29597 -5.45893  1.000 11.23776 ? 60   VAL A C   1 
ATOM   451  O  O   . VAL A 1 60  ? -34.24939 31.08749 -5.03258  1.000 9.05584  ? 60   VAL A O   1 
ATOM   452  C  CB  . VAL A 1 60  ? -33.76021 32.94454 -7.21284  1.000 11.29303 ? 60   VAL A CB  1 
ATOM   453  C  CG1 . VAL A 1 60  ? -33.64036 34.40959 -7.66875  1.000 11.01664 ? 60   VAL A CG1 1 
ATOM   454  C  CG2 . VAL A 1 60  ? -33.53171 31.98999 -8.37087  1.000 7.90638  ? 60   VAL A CG2 1 
ATOM   455  N  N   . MET A 1 61  ? -32.15716 30.36322 -5.36502  1.000 10.15893 ? 61   MET A N   1 
ATOM   456  C  CA  . MET A 1 61  ? -32.43668 29.12185 -4.64976  1.000 8.52064  ? 61   MET A CA  1 
ATOM   457  C  C   . MET A 1 61  ? -31.68010 29.00933 -3.32924  1.000 11.69604 ? 61   MET A C   1 
ATOM   458  O  O   . MET A 1 61  ? -31.75487 27.96433 -2.67461  1.000 11.97254 ? 61   MET A O   1 
ATOM   459  C  CB  . MET A 1 61  ? -32.15502 27.91450 -5.54868  1.000 8.66542  ? 61   MET A CB  1 
ATOM   460  C  CG  . MET A 1 61  ? -33.12340 27.84767 -6.74087  1.000 8.47083  ? 61   MET A CG  1 
ATOM   461  S  SD  . MET A 1 61  ? -32.94246 26.38174 -7.77383  1.000 10.69026 ? 61   MET A SD  1 
ATOM   462  C  CE  . MET A 1 61  ? -33.53028 26.98885 -9.36778  1.000 7.51946  ? 61   MET A CE  1 
ATOM   463  N  N   . LYS A 1 62  ? -30.98071 30.06690 -2.90636  1.000 8.44772  ? 62   LYS A N   1 
ATOM   464  C  CA  . LYS A 1 62  ? -30.36190 30.08835 -1.58672  1.000 7.91754  ? 62   LYS A CA  1 
ATOM   465  C  C   . LYS A 1 62  ? -31.44391 30.19242 -0.50392  1.000 9.24261  ? 62   LYS A C   1 
ATOM   466  O  O   . LYS A 1 62  ? -32.55862 30.64221 -0.77731  1.000 8.84053  ? 62   LYS A O   1 
ATOM   467  C  CB  . LYS A 1 62  ? -29.37459 31.25218 -1.49134  1.000 7.98579  ? 62   LYS A CB  1 
ATOM   468  C  CG  . LYS A 1 62  ? -28.08460 30.99110 -2.30593  1.000 10.98877 ? 62   LYS A CG  1 
ATOM   469  C  CD  . LYS A 1 62  ? -27.23726 32.24166 -2.52177  1.000 14.34242 ? 62   LYS A CD  1 
ATOM   470  C  CE  . LYS A 1 62  ? -26.00837 31.93325 -3.40257  1.000 14.62263 ? 62   LYS A CE  1 
ATOM   471  N  NZ  . LYS A 1 62  ? -25.30664 33.17469 -3.84515  1.000 9.72432  ? 62   LYS A NZ  1 
ATOM   472  N  N   . PRO A 1 63  ? -31.13713 29.76958 0.73038   1.000 9.44867  ? 63   PRO A N   1 
ATOM   473  C  CA  . PRO A 1 63  ? -32.18978 29.67441 1.76785   1.000 9.08872  ? 63   PRO A CA  1 
ATOM   474  C  C   . PRO A 1 63  ? -32.99631 30.93914 1.98972   1.000 10.50387 ? 63   PRO A C   1 
ATOM   475  O  O   . PRO A 1 63  ? -34.22717 30.86182 2.12018   1.000 11.66681 ? 63   PRO A O   1 
ATOM   476  C  CB  . PRO A 1 63  ? -31.39317 29.30301 3.02339   1.000 7.48141  ? 63   PRO A CB  1 
ATOM   477  C  CG  . PRO A 1 63  ? -30.24717 28.51118 2.49280   1.000 7.90310  ? 63   PRO A CG  1 
ATOM   478  C  CD  . PRO A 1 63  ? -29.85747 29.20951 1.20658   1.000 8.02233  ? 63   PRO A CD  1 
ATOM   479  N  N   . ILE A 1 64  ? -32.34916 32.10654 2.03448   1.000 11.85065 ? 64   ILE A N   1 
ATOM   480  C  CA  . ILE A 1 64  ? -33.08899 33.33021 2.33099   1.000 10.94635 ? 64   ILE A CA  1 
ATOM   481  C  C   . ILE A 1 64  ? -34.01079 33.69238 1.17041   1.000 15.74818 ? 64   ILE A C   1 
ATOM   482  O  O   . ILE A 1 64  ? -35.04768 34.33758 1.37038   1.000 10.62097 ? 64   ILE A O   1 
ATOM   483  C  CB  . ILE A 1 64  ? -32.11889 34.48362 2.67328   1.000 16.12072 ? 64   ILE A CB  1 
ATOM   484  C  CG1 . ILE A 1 64  ? -32.86505 35.62391 3.38453   1.000 13.07778 ? 64   ILE A CG1 1 
ATOM   485  C  CG2 . ILE A 1 64  ? -31.38742 34.99584 1.40546   1.000 11.75917 ? 64   ILE A CG2 1 
ATOM   486  C  CD1 . ILE A 1 64  ? -31.95822 36.62897 4.11554   1.000 14.41285 ? 64   ILE A CD1 1 
ATOM   487  N  N   . SER A 1 65  ? -33.66271 33.28258 -0.05399  1.000 11.04047 ? 65   SER A N   1 
ATOM   488  C  CA  . SER A 1 65  ? -34.53128 33.55561 -1.19354  1.000 11.45868 ? 65   SER A CA  1 
ATOM   489  C  C   . SER A 1 65  ? -35.73519 32.62747 -1.20770  1.000 13.13847 ? 65   SER A C   1 
ATOM   490  O  O   . SER A 1 65  ? -36.79981 33.01400 -1.69528  1.000 12.99300 ? 65   SER A O   1 
ATOM   491  C  CB  . SER A 1 65  ? -33.76243 33.41895 -2.51385  1.000 12.86968 ? 65   SER A CB  1 
ATOM   492  O  OG  . SER A 1 65  ? -32.55043 34.16016 -2.48369  1.000 19.83131 ? 65   SER A OG  1 
ATOM   493  N  N   . ILE A 1 66  ? -35.58690 31.41572 -0.68167  1.000 12.38258 ? 66   ILE A N   1 
ATOM   494  C  CA  . ILE A 1 66  ? -36.67291 30.43807 -0.70618  1.000 13.00580 ? 66   ILE A CA  1 
ATOM   495  C  C   . ILE A 1 66  ? -37.61044 30.60441 0.48770   1.000 13.05451 ? 66   ILE A C   1 
ATOM   496  O  O   . ILE A 1 66  ? -38.83131 30.61800 0.31884   1.000 11.80849 ? 66   ILE A O   1 
ATOM   497  C  CB  . ILE A 1 66  ? -36.09994 29.00722 -0.77828  1.000 12.87177 ? 66   ILE A CB  1 
ATOM   498  C  CG1 . ILE A 1 66  ? -35.34286 28.79397 -2.10013  1.000 11.95759 ? 66   ILE A CG1 1 
ATOM   499  C  CG2 . ILE A 1 66  ? -37.22163 27.96310 -0.61869  1.000 8.26038  ? 66   ILE A CG2 1 
ATOM   500  C  CD1 . ILE A 1 66  ? -36.23793 28.69792 -3.31216  1.000 10.26240 ? 66   ILE A CD1 1 
ATOM   501  N  N   . GLN A 1 67  ? -37.09004 30.71582 1.71592   1.000 8.79611  ? 67   GLN A N   1 
ATOM   502  C  CA  . GLN A 1 67  ? -37.93197 30.84747 2.91259   1.000 10.33514 ? 67   GLN A CA  1 
ATOM   503  C  C   . GLN A 1 67  ? -37.47771 32.02973 3.76438   1.000 10.29490 ? 67   GLN A C   1 
ATOM   504  O  O   . GLN A 1 67  ? -36.93205 31.84966 4.85734   1.000 12.55429 ? 67   GLN A O   1 
ATOM   505  C  CB  . GLN A 1 67  ? -37.93250 29.55822 3.73902   1.000 10.93156 ? 67   GLN A CB  1 
ATOM   506  C  CG  . GLN A 1 67  ? -39.26047 29.35160 4.51823   1.000 10.60733 ? 67   GLN A CG  1 
ATOM   507  C  CD  . GLN A 1 67  ? -39.26408 28.17435 5.49873   1.000 10.65976 ? 67   GLN A CD  1 
ATOM   508  O  OE1 . GLN A 1 67  ? -40.15082 28.07345 6.34852   1.000 12.60756 ? 67   GLN A OE1 1 
ATOM   509  N  NE2 . GLN A 1 67  ? -38.29489 27.27412 5.37084   1.000 10.78000 ? 67   GLN A NE2 1 
ATOM   510  N  N   . PRO A 1 68  ? -37.70377 33.26030 3.29901   1.000 11.58824 ? 68   PRO A N   1 
ATOM   511  C  CA  . PRO A 1 68  ? -37.20594 34.42772 4.04802   1.000 13.80872 ? 68   PRO A CA  1 
ATOM   512  C  C   . PRO A 1 68  ? -37.87672 34.61876 5.39499   1.000 14.26973 ? 68   PRO A C   1 
ATOM   513  O  O   . PRO A 1 68  ? -37.28153 35.24776 6.27851   1.000 14.90900 ? 68   PRO A O   1 
ATOM   514  C  CB  . PRO A 1 68  ? -37.49718 35.59821 3.10583   1.000 10.23251 ? 68   PRO A CB  1 
ATOM   515  C  CG  . PRO A 1 68  ? -38.68811 35.14021 2.31341   1.000 14.17002 ? 68   PRO A CG  1 
ATOM   516  C  CD  . PRO A 1 68  ? -38.45500 33.65811 2.09597   1.000 13.86311 ? 68   PRO A CD  1 
ATOM   517  N  N   . GLU A 1 69  ? -39.09320 34.11022 5.57208   1.000 11.63290 ? 69   GLU A N   1 
ATOM   518  C  CA  . GLU A 1 69  ? -39.76713 34.02814 6.85785   1.000 12.49075 ? 69   GLU A CA  1 
ATOM   519  C  C   . GLU A 1 69  ? -40.31514 32.61765 6.98486   1.000 13.58484 ? 69   GLU A C   1 
ATOM   520  O  O   . GLU A 1 69  ? -40.66064 31.99062 5.98189   1.000 14.84439 ? 69   GLU A O   1 
ATOM   521  C  CB  . GLU A 1 69  ? -40.92935 35.04196 6.98831   1.000 19.73128 ? 69   GLU A CB  1 
ATOM   522  C  CG  . GLU A 1 69  ? -40.60830 36.48874 6.60636   1.000 26.46150 ? 69   GLU A CG  1 
ATOM   523  C  CD  . GLU A 1 69  ? -41.85193 37.39457 6.62738   1.000 30.86117 ? 69   GLU A CD  1 
ATOM   524  O  OE1 . GLU A 1 69  ? -42.67545 37.27561 7.55601   1.000 35.36983 ? 69   GLU A OE1 1 
ATOM   525  O  OE2 . GLU A 1 69  ? -42.00590 38.23250 5.71588   1.000 41.05004 ? 69   GLU A OE2 1 
ATOM   526  N  N   . GLU A 1 70  ? -40.38820 32.11101 8.20848   1.000 11.77345 ? 70   GLU A N   1 
ATOM   527  C  CA  . GLU A 1 70  ? -40.84847 30.74033 8.39853   1.000 14.76513 ? 70   GLU A CA  1 
ATOM   528  C  C   . GLU A 1 70  ? -42.27560 30.56760 7.89056   1.000 15.93756 ? 70   GLU A C   1 
ATOM   529  O  O   . GLU A 1 70  ? -43.17966 31.29769 8.30446   1.000 16.66249 ? 70   GLU A O   1 
ATOM   530  C  CB  . GLU A 1 70  ? -40.77132 30.35314 9.86879   1.000 13.91094 ? 70   GLU A CB  1 
ATOM   531  C  CG  . GLU A 1 70  ? -41.00688 28.87927 10.08321  1.000 13.41504 ? 70   GLU A CG  1 
ATOM   532  C  CD  . GLU A 1 70  ? -40.88881 28.46733 11.54089  1.000 16.15661 ? 70   GLU A CD  1 
ATOM   533  O  OE1 . GLU A 1 70  ? -40.65955 29.34889 12.40198  1.000 17.76880 ? 70   GLU A OE1 1 
ATOM   534  O  OE2 . GLU A 1 70  ? -41.02902 27.26123 11.81257  1.000 15.65375 ? 70   GLU A OE2 1 
ATOM   535  N  N   . GLY A 1 71  ? -42.48075 29.58450 7.01048   1.000 14.38259 ? 71   GLY A N   1 
ATOM   536  C  CA  . GLY A 1 71  ? -43.77641 29.35539 6.40731   1.000 14.34961 ? 71   GLY A CA  1 
ATOM   537  C  C   . GLY A 1 71  ? -44.01495 30.14208 5.13303   1.000 17.56813 ? 71   GLY A C   1 
ATOM   538  O  O   . GLY A 1 71  ? -45.02431 29.90415 4.45355   1.000 13.60287 ? 71   GLY A O   1 
ATOM   539  N  N   . LYS A 1 72  ? -43.11202 31.06864 4.79345   1.000 13.30085 ? 72   LYS A N   1 
ATOM   540  C  CA  . LYS A 1 72  ? -43.15933 31.86221 3.56203   1.000 11.85280 ? 72   LYS A CA  1 
ATOM   541  C  C   . LYS A 1 72  ? -42.21228 31.29651 2.52212   1.000 12.87261 ? 72   LYS A C   1 
ATOM   542  O  O   . LYS A 1 72  ? -41.02111 31.59419 2.54811   1.000 13.79598 ? 72   LYS A O   1 
ATOM   543  C  CB  . LYS A 1 72  ? -42.77611 33.31304 3.83639   1.000 21.94597 ? 72   LYS A CB  1 
ATOM   544  C  CG  . LYS A 1 72  ? -43.78401 34.01997 4.58065   1.000 27.37189 ? 72   LYS A CG  1 
ATOM   545  C  CD  . LYS A 1 72  ? -44.82263 34.17122 3.60267   1.000 42.81154 ? 72   LYS A CD  1 
ATOM   546  C  CE  . LYS A 1 72  ? -45.92597 34.93665 4.18754   1.000 44.26558 ? 72   LYS A CE  1 
ATOM   547  N  NZ  . LYS A 1 72  ? -45.47787 36.31176 4.24249   1.000 47.41084 ? 72   LYS A NZ  1 
ATOM   548  N  N   . PHE A 1 73  ? -42.74632 30.54722 1.56296   1.000 14.28440 ? 73   PHE A N   1 
ATOM   549  C  CA  . PHE A 1 73  ? -41.91999 29.96109 0.51672   1.000 13.46573 ? 73   PHE A CA  1 
ATOM   550  C  C   . PHE A 1 73  ? -42.09834 30.75293 -0.76763  1.000 17.30169 ? 73   PHE A C   1 
ATOM   551  O  O   . PHE A 1 73  ? -43.22263 30.92733 -1.25322  1.000 16.27752 ? 73   PHE A O   1 
ATOM   552  C  CB  . PHE A 1 73  ? -42.24784 28.48288 0.31626   1.000 10.79391 ? 73   PHE A CB  1 
ATOM   553  C  CG  . PHE A 1 73  ? -41.82415 27.62553 1.47558   1.000 13.32669 ? 73   PHE A CG  1 
ATOM   554  C  CD1 . PHE A 1 73  ? -42.69852 27.39960 2.53930   1.000 12.11756 ? 73   PHE A CD1 1 
ATOM   555  C  CD2 . PHE A 1 73  ? -40.55100 27.07085 1.52392   1.000 8.71594  ? 73   PHE A CD2 1 
ATOM   556  C  CE1 . PHE A 1 73  ? -42.31115 26.62659 3.62386   1.000 10.57442 ? 73   PHE A CE1 1 
ATOM   557  C  CE2 . PHE A 1 73  ? -40.15492 26.28294 2.60844   1.000 14.06546 ? 73   PHE A CE2 1 
ATOM   558  C  CZ  . PHE A 1 73  ? -41.03677 26.06029 3.65899   1.000 10.78266 ? 73   PHE A CZ  1 
ATOM   559  N  N   . ASN A 1 74  ? -40.99266 31.25124 -1.30111  1.000 13.61498 ? 74   ASN A N   1 
ATOM   560  C  CA  . ASN A 1 74  ? -41.02041 32.02156 -2.53893  1.000 14.84978 ? 74   ASN A CA  1 
ATOM   561  C  C   . ASN A 1 74  ? -40.33233 31.17409 -3.60962  1.000 17.45733 ? 74   ASN A C   1 
ATOM   562  O  O   . ASN A 1 74  ? -39.11969 31.25446 -3.80549  1.000 13.36310 ? 74   ASN A O   1 
ATOM   563  C  CB  . ASN A 1 74  ? -40.35809 33.38485 -2.35193  1.000 16.17729 ? 74   ASN A CB  1 
ATOM   564  C  CG  . ASN A 1 74  ? -41.18598 34.30864 -1.45316  1.000 31.86494 ? 74   ASN A CG  1 
ATOM   565  O  OD1 . ASN A 1 74  ? -42.36270 34.03999 -1.18745  1.000 34.93892 ? 74   ASN A OD1 1 
ATOM   566  N  ND2 . ASN A 1 74  ? -40.58357 35.41291 -1.00506  1.000 37.68982 ? 74   ASN A ND2 1 
ATOM   567  N  N   . PHE A 1 75  ? -41.11936 30.34454 -4.29317  1.000 10.40469 ? 75   PHE A N   1 
ATOM   568  C  CA  . PHE A 1 75  ? -40.59936 29.51908 -5.37509  1.000 12.26563 ? 75   PHE A CA  1 
ATOM   569  C  C   . PHE A 1 75  ? -40.73612 30.14845 -6.76798  1.000 12.10308 ? 75   PHE A C   1 
ATOM   570  O  O   . PHE A 1 75  ? -40.26597 29.53312 -7.73110  1.000 14.02663 ? 75   PHE A O   1 
ATOM   571  C  CB  . PHE A 1 75  ? -41.29891 28.15415 -5.41751  1.000 11.20377 ? 75   PHE A CB  1 
ATOM   572  C  CG  . PHE A 1 75  ? -41.01792 27.26671 -4.23407  1.000 11.67124 ? 75   PHE A CG  1 
ATOM   573  C  CD1 . PHE A 1 75  ? -39.75231 26.73815 -4.01444  1.000 12.96590 ? 75   PHE A CD1 1 
ATOM   574  C  CD2 . PHE A 1 75  ? -42.04043 26.92769 -3.35458  1.000 13.60548 ? 75   PHE A CD2 1 
ATOM   575  C  CE1 . PHE A 1 75  ? -39.51008 25.89697 -2.92321  1.000 10.54913 ? 75   PHE A CE1 1 
ATOM   576  C  CE2 . PHE A 1 75  ? -41.80609 26.08629 -2.26975  1.000 10.61059 ? 75   PHE A CE2 1 
ATOM   577  C  CZ  . PHE A 1 75  ? -40.54467 25.57474 -2.05711  1.000 11.34351 ? 75   PHE A CZ  1 
ATOM   578  N  N   . GLU A 1 76  ? -41.34715 31.33599 -6.93242  1.000 13.06942 ? 76   GLU A N   1 
ATOM   579  C  CA  . GLU A 1 76  ? -41.59917 31.78748 -8.31082  1.000 16.70606 ? 76   GLU A CA  1 
ATOM   580  C  C   . GLU A 1 76  ? -40.30891 31.97524 -9.08073  1.000 13.87057 ? 76   GLU A C   1 
ATOM   581  O  O   . GLU A 1 76  ? -40.23333 31.63641 -10.26836 1.000 15.42037 ? 76   GLU A O   1 
ATOM   582  C  CB  . GLU A 1 76  ? -42.34448 33.11219 -8.41533  1.000 22.50746 ? 76   GLU A CB  1 
ATOM   583  C  CG  . GLU A 1 76  ? -43.43965 33.40608 -7.49415  1.000 34.94552 ? 76   GLU A CG  1 
ATOM   584  C  CD  . GLU A 1 76  ? -43.32497 34.90119 -7.12882  1.000 57.77175 ? 76   GLU A CD  1 
ATOM   585  O  OE1 . GLU A 1 76  ? -44.28768 35.65259 -7.43419  1.000 61.03776 ? 76   GLU A OE1 1 
ATOM   586  O  OE2 . GLU A 1 76  ? -42.29932 35.24599 -6.54108  1.000 58.86616 ? 76   GLU A OE2 1 
ATOM   587  N  N   . GLN A 1 77  ? -39.31364 32.61647 -8.46836  1.000 11.14196 ? 77   GLN A N   1 
ATOM   588  C  CA  . GLN A 1 77  ? -38.06937 32.87754 -9.19255  1.000 15.34458 ? 77   GLN A CA  1 
ATOM   589  C  C   . GLN A 1 77  ? -37.34886 31.57498 -9.55744  1.000 11.91870 ? 77   GLN A C   1 
ATOM   590  O  O   . GLN A 1 77  ? -36.93532 31.38018 -10.70717 1.000 12.33594 ? 77   GLN A O   1 
ATOM   591  C  CB  . GLN A 1 77  ? -37.16070 33.80296 -8.37798  1.000 17.97435 ? 77   GLN A CB  1 
ATOM   592  C  CG  . GLN A 1 77  ? -37.72290 35.22526 -8.23557  1.000 15.84370 ? 77   GLN A CG  1 
ATOM   593  C  CD  . GLN A 1 77  ? -37.35651 36.11644 -9.42077  1.000 29.40003 ? 77   GLN A CD  1 
ATOM   594  O  OE1 . GLN A 1 77  ? -38.04723 36.13322 -10.44749 1.000 33.88380 ? 77   GLN A OE1 1 
ATOM   595  N  NE2 . GLN A 1 77  ? -36.25334 36.85743 -9.28286  1.000 31.64555 ? 77   GLN A NE2 1 
ATOM   596  N  N   . ALA A 1 78  ? -37.24307 30.64881 -8.60333  1.000 9.06911  ? 78   ALA A N   1 
ATOM   597  C  CA  . ALA A 1 78  ? -36.64862 29.34803 -8.89647  1.000 10.33760 ? 78   ALA A CA  1 
ATOM   598  C  C   . ALA A 1 78  ? -37.44860 28.59926 -9.95408  1.000 10.95296 ? 78   ALA A C   1 
ATOM   599  O  O   . ALA A 1 78  ? -36.86636 27.95856 -10.83344 1.000 12.40418 ? 78   ALA A O   1 
ATOM   600  C  CB  . ALA A 1 78  ? -36.54605 28.51881 -7.61698  1.000 7.65461  ? 78   ALA A CB  1 
ATOM   601  N  N   . ASP A 1 79  ? -38.78744 28.66574 -9.88031  1.000 12.69921 ? 79   ASP A N   1 
ATOM   602  C  CA  . ASP A 1 79  ? -39.63257 28.01063 -10.87872 1.000 12.32182 ? 79   ASP A CA  1 
ATOM   603  C  C   . ASP A 1 79  ? -39.28483 28.46284 -12.29579 1.000 11.16119 ? 79   ASP A C   1 
ATOM   604  O  O   . ASP A 1 79  ? -39.32522 27.66498 -13.23847 1.000 10.65643 ? 79   ASP A O   1 
ATOM   605  C  CB  . ASP A 1 79  ? -41.11008 28.30371 -10.61045 1.000 11.48632 ? 79   ASP A CB  1 
ATOM   606  C  CG  . ASP A 1 79  ? -41.67634 27.53409 -9.41432  1.000 16.31685 ? 79   ASP A CG  1 
ATOM   607  O  OD1 . ASP A 1 79  ? -41.06351 26.55433 -8.93714  1.000 14.20928 ? 79   ASP A OD1 1 
ATOM   608  O  OD2 . ASP A 1 79  ? -42.76730 27.92281 -8.96227  1.000 13.40399 ? 79   ASP A OD2 1 
ATOM   609  N  N   . ARG A 1 80  ? -38.98819 29.75026 -12.47279 1.000 11.26235 ? 80   ARG A N   1 
ATOM   610  C  CA  . ARG A 1 80  ? -38.70232 30.25752 -13.81096 1.000 12.63174 ? 80   ARG A CA  1 
ATOM   611  C  C   . ARG A 1 80  ? -37.43125 29.63302 -14.36815 1.000 13.42819 ? 80   ARG A C   1 
ATOM   612  O  O   . ARG A 1 80  ? -37.34663 29.34153 -15.56571 1.000 11.48611 ? 80   ARG A O   1 
ATOM   613  C  CB  . ARG A 1 80  ? -38.57801 31.77939 -13.77230 1.000 16.60611 ? 80   ARG A CB  1 
ATOM   614  C  CG  . ARG A 1 80  ? -39.87393 32.48591 -13.47824 1.000 18.44805 ? 80   ARG A CG  1 
ATOM   615  C  CD  . ARG A 1 80  ? -39.70954 33.98770 -13.32926 1.000 24.27187 ? 80   ARG A CD  1 
ATOM   616  N  NE  . ARG A 1 80  ? -41.02242 34.61214 -13.15083 1.000 41.25370 ? 80   ARG A NE  1 
ATOM   617  C  CZ  . ARG A 1 80  ? -41.42302 35.23576 -12.04299 1.000 43.26265 ? 80   ARG A CZ  1 
ATOM   618  N  NH1 . ARG A 1 80  ? -40.60998 35.35036 -10.99213 1.000 39.34011 ? 80   ARG A NH1 1 
ATOM   619  N  NH2 . ARG A 1 80  ? -42.64322 35.75449 -11.98688 1.000 46.55446 ? 80   ARG A NH2 1 
ATOM   620  N  N   . ILE A 1 81  ? -36.42989 29.41919 -13.50680 1.000 9.31853  ? 81   ILE A N   1 
ATOM   621  C  CA  . ILE A 1 81  ? -35.19902 28.77847 -13.94415 1.000 8.34991  ? 81   ILE A CA  1 
ATOM   622  C  C   . ILE A 1 81  ? -35.45401 27.31183 -14.27206 1.000 9.93415  ? 81   ILE A C   1 
ATOM   623  O  O   . ILE A 1 81  ? -34.96739 26.79555 -15.28147 1.000 8.86789  ? 81   ILE A O   1 
ATOM   624  C  CB  . ILE A 1 81  ? -34.10249 28.95955 -12.87615 1.000 12.45985 ? 81   ILE A CB  1 
ATOM   625  C  CG1 . ILE A 1 81  ? -33.69248 30.44479 -12.79024 1.000 8.07079  ? 81   ILE A CG1 1 
ATOM   626  C  CG2 . ILE A 1 81  ? -32.87530 28.08902 -13.19717 1.000 8.51505  ? 81   ILE A CG2 1 
ATOM   627  C  CD1 . ILE A 1 81  ? -32.77198 30.75574 -11.64360 1.000 7.38419  ? 81   ILE A CD1 1 
ATOM   628  N  N   . VAL A 1 82  ? -36.25482 26.62957 -13.44661 1.000 10.78627 ? 82   VAL A N   1 
ATOM   629  C  CA  . VAL A 1 82  ? -36.58767 25.22918 -13.70757 1.000 9.59194  ? 82   VAL A CA  1 
ATOM   630  C  C   . VAL A 1 82  ? -37.36794 25.08873 -15.01236 1.000 10.90903 ? 82   VAL A C   1 
ATOM   631  O  O   . VAL A 1 82  ? -37.10637 24.18456 -15.81720 1.000 11.51489 ? 82   VAL A O   1 
ATOM   632  C  CB  . VAL A 1 82  ? -37.37263 24.65089 -12.51319 1.000 11.92875 ? 82   VAL A CB  1 
ATOM   633  C  CG1 . VAL A 1 82  ? -37.87622 23.25736 -12.82160 1.000 11.08845 ? 82   VAL A CG1 1 
ATOM   634  C  CG2 . VAL A 1 82  ? -36.49036 24.66295 -11.25735 1.000 9.44427  ? 82   VAL A CG2 1 
ATOM   635  N  N   . LYS A 1 83  ? -38.35328 25.96320 -15.23082 1.000 10.59351 ? 83   LYS A N   1 
ATOM   636  C  CA  . LYS A 1 83  ? -39.15111 25.89808 -16.45459 1.000 13.28693 ? 83   LYS A CA  1 
ATOM   637  C  C   . LYS A 1 83  ? -38.27956 26.08850 -17.69303 1.000 11.85797 ? 83   LYS A C   1 
ATOM   638  O  O   . LYS A 1 83  ? -38.42907 25.36820 -18.68389 1.000 12.73575 ? 83   LYS A O   1 
ATOM   639  C  CB  . LYS A 1 83  ? -40.25785 26.95627 -16.41159 1.000 17.24129 ? 83   LYS A CB  1 
ATOM   640  C  CG  . LYS A 1 83  ? -41.11810 26.99810 -17.67991 1.000 25.24402 ? 83   LYS A CG  1 
ATOM   641  C  CD  . LYS A 1 83  ? -42.18606 28.09792 -17.63663 1.000 29.20905 ? 83   LYS A CD  1 
ATOM   642  C  CE  . LYS A 1 83  ? -41.58451 29.48160 -17.85332 1.000 33.98940 ? 83   LYS A CE  1 
ATOM   643  N  NZ  . LYS A 1 83  ? -42.41006 30.58801 -17.26856 1.000 41.39369 ? 83   LYS A NZ  1 
ATOM   644  N  N   . PHE A 1 84  ? -37.35788 27.05240 -17.64874 1.000 10.14009 ? 84   PHE A N   1 
ATOM   645  C  CA  . PHE A 1 84  ? -36.47702 27.30093 -18.78848 1.000 10.87155 ? 84   PHE A CA  1 
ATOM   646  C  C   . PHE A 1 84  ? -35.57628 26.10545 -19.05302 1.000 10.10249 ? 84   PHE A C   1 
ATOM   647  O  O   . PHE A 1 84  ? -35.37622 25.70352 -20.20873 1.000 10.62223 ? 84   PHE A O   1 
ATOM   648  C  CB  . PHE A 1 84  ? -35.63495 28.56047 -18.53323 1.000 10.40105 ? 84   PHE A CB  1 
ATOM   649  C  CG  . PHE A 1 84  ? -34.70409 28.91866 -19.66714 1.000 10.16069 ? 84   PHE A CG  1 
ATOM   650  C  CD1 . PHE A 1 84  ? -35.14795 29.68718 -20.73551 1.000 11.17158 ? 84   PHE A CD1 1 
ATOM   651  C  CD2 . PHE A 1 84  ? -33.38611 28.48926 -19.66427 1.000 8.43522  ? 84   PHE A CD2 1 
ATOM   652  C  CE1 . PHE A 1 84  ? -34.28341 30.03645 -21.78709 1.000 9.17047  ? 84   PHE A CE1 1 
ATOM   653  C  CE2 . PHE A 1 84  ? -32.51538 28.84216 -20.71241 1.000 10.65142 ? 84   PHE A CE2 1 
ATOM   654  C  CZ  . PHE A 1 84  ? -32.97488 29.61649 -21.76860 1.000 7.98615  ? 84   PHE A CZ  1 
ATOM   655  N  N   . ALA A 1 85  ? -35.01703 25.52572 -17.99248 1.000 11.30353 ? 85   ALA A N   1 
ATOM   656  C  CA  . ALA A 1 85  ? -34.15278 24.36652 -18.15774 1.000 9.30839  ? 85   ALA A CA  1 
ATOM   657  C  C   . ALA A 1 85  ? -34.90312 23.21570 -18.80589 1.000 11.04039 ? 85   ALA A C   1 
ATOM   658  O  O   . ALA A 1 85  ? -34.40003 22.57899 -19.73825 1.000 9.70373  ? 85   ALA A O   1 
ATOM   659  C  CB  . ALA A 1 85  ? -33.59616 23.93290 -16.80414 1.000 9.52741  ? 85   ALA A CB  1 
ATOM   660  N  N   . LYS A 1 86  ? -36.11138 22.92366 -18.31712 1.000 11.21099 ? 86   LYS A N   1 
ATOM   661  C  CA  . LYS A 1 86  ? -36.85515 21.79260 -18.86271 1.000 14.95127 ? 86   LYS A CA  1 
ATOM   662  C  C   . LYS A 1 86  ? -37.19456 22.02050 -20.32770 1.000 14.59708 ? 86   LYS A C   1 
ATOM   663  O  O   . LYS A 1 86  ? -37.11038 21.09562 -21.13873 1.000 15.74396 ? 86   LYS A O   1 
ATOM   664  C  CB  . LYS A 1 86  ? -38.12954 21.54140 -18.05470 1.000 18.30712 ? 86   LYS A CB  1 
ATOM   665  C  CG  . LYS A 1 86  ? -37.88679 20.98982 -16.66287 1.000 21.05393 ? 86   LYS A CG  1 
ATOM   666  C  CD  . LYS A 1 86  ? -39.16300 20.99723 -15.82333 1.000 28.29119 ? 86   LYS A CD  1 
ATOM   667  C  CE  . LYS A 1 86  ? -40.02014 19.77148 -16.09024 1.000 30.45748 ? 86   LYS A CE  1 
ATOM   668  N  NZ  . LYS A 1 86  ? -40.64991 19.82044 -17.43338 1.000 40.52022 ? 86   LYS A NZ  1 
ATOM   669  N  N   . ALA A 1 87  ? -37.56240 23.25016 -20.68903 1.000 14.81551 ? 87   ALA A N   1 
ATOM   670  C  CA  . ALA A 1 87  ? -37.89403 23.53780 -22.07973 1.000 15.63349 ? 87   ALA A CA  1 
ATOM   671  C  C   . ALA A 1 87  ? -36.69245 23.42634 -22.99965 1.000 14.79529 ? 87   ALA A C   1 
ATOM   672  O  O   . ALA A 1 87  ? -36.86778 23.30633 -24.21266 1.000 13.71570 ? 87   ALA A O   1 
ATOM   673  C  CB  . ALA A 1 87  ? -38.49419 24.93939 -22.20958 1.000 14.32830 ? 87   ALA A CB  1 
ATOM   674  N  N   . ASN A 1 88  ? -35.47698 23.48054 -22.46157 1.000 13.58401 ? 88   ASN A N   1 
ATOM   675  C  CA  . ASN A 1 88  ? -34.28487 23.44282 -23.29322 1.000 11.51507 ? 88   ASN A CA  1 
ATOM   676  C  C   . ASN A 1 88  ? -33.42042 22.21924 -23.02234 1.000 11.98874 ? 88   ASN A C   1 
ATOM   677  O  O   . ASN A 1 88  ? -32.27643 22.16620 -23.48710 1.000 14.92929 ? 88   ASN A O   1 
ATOM   678  C  CB  . ASN A 1 88  ? -33.50101 24.74766 -23.11168 1.000 10.53297 ? 88   ASN A CB  1 
ATOM   679  C  CG  . ASN A 1 88  ? -34.27687 25.94990 -23.65901 1.000 13.72589 ? 88   ASN A CG  1 
ATOM   680  O  OD1 . ASN A 1 88  ? -34.31048 26.16662 -24.86543 1.000 13.56982 ? 88   ASN A OD1 1 
ATOM   681  N  ND2 . ASN A 1 88  ? -34.94693 26.69336 -22.77935 1.000 10.03925 ? 88   ASN A ND2 1 
ATOM   682  N  N   . GLY A 1 89  ? -33.95090 21.21879 -22.31977 1.000 15.14126 ? 89   GLY A N   1 
ATOM   683  C  CA  . GLY A 1 89  ? -33.21185 19.99111 -22.07351 1.000 9.23377  ? 89   GLY A CA  1 
ATOM   684  C  C   . GLY A 1 89  ? -31.95492 20.18249 -21.25226 1.000 11.68951 ? 89   GLY A C   1 
ATOM   685  O  O   . GLY A 1 89  ? -30.97660 19.47223 -21.46610 1.000 15.69878 ? 89   GLY A O   1 
ATOM   686  N  N   . MET A 1 90  ? -31.94961 21.12433 -20.31760 1.000 8.81833  ? 90   MET A N   1 
ATOM   687  C  CA  . MET A 1 90  ? -30.78581 21.36101 -19.46831 1.000 9.60286  ? 90   MET A CA  1 
ATOM   688  C  C   . MET A 1 90  ? -30.89647 20.60634 -18.14012 1.000 9.35019  ? 90   MET A C   1 
ATOM   689  O  O   . MET A 1 90  ? -31.96311 20.56546 -17.52837 1.000 9.83585  ? 90   MET A O   1 
ATOM   690  C  CB  . MET A 1 90  ? -30.64313 22.86550 -19.19570 1.000 9.25905  ? 90   MET A CB  1 
ATOM   691  C  CG  . MET A 1 90  ? -30.60256 23.74421 -20.45210 1.000 7.89390  ? 90   MET A CG  1 
ATOM   692  S  SD  . MET A 1 90  ? -30.58113 25.49312 -20.04564 1.000 8.08464  ? 90   MET A SD  1 
ATOM   693  C  CE  . MET A 1 90  ? -28.79976 25.76995 -19.90740 1.000 4.13004  ? 90   MET A CE  1 
ATOM   694  N  N   . ASP A 1 91  ? -29.78604 20.02463 -17.68935 1.000 7.34304  ? 91   ASP A N   1 
ATOM   695  C  CA  . ASP A 1 91  ? -29.68905 19.59273 -16.29926 1.000 8.94792  ? 91   ASP A CA  1 
ATOM   696  C  C   . ASP A 1 91  ? -29.84684 20.79555 -15.36752 1.000 9.63562  ? 91   ASP A C   1 
ATOM   697  O  O   . ASP A 1 91  ? -29.53964 21.93142 -15.72898 1.000 9.60859  ? 91   ASP A O   1 
ATOM   698  C  CB  . ASP A 1 91  ? -28.33412 18.93809 -16.01953 1.000 11.15041 ? 91   ASP A CB  1 
ATOM   699  C  CG  . ASP A 1 91  ? -28.18692 17.56370 -16.65070 1.000 12.39533 ? 91   ASP A CG  1 
ATOM   700  O  OD1 . ASP A 1 91  ? -29.19413 16.97697 -17.08553 1.000 11.96499 ? 91   ASP A OD1 1 
ATOM   701  O  OD2 . ASP A 1 91  ? -27.04048 17.07784 -16.70714 1.000 15.08228 ? 91   ASP A OD2 1 
ATOM   702  N  N   . ILE A 1 92  ? -30.29505 20.54173 -14.14235 1.000 8.12529  ? 92   ILE A N   1 
ATOM   703  C  CA  . ILE A 1 92  ? -30.42883 21.58819 -13.13217 1.000 7.79286  ? 92   ILE A CA  1 
ATOM   704  C  C   . ILE A 1 92  ? -29.63175 21.19219 -11.89861 1.000 10.74532 ? 92   ILE A C   1 
ATOM   705  O  O   . ILE A 1 92  ? -29.73261 20.05203 -11.43261 1.000 9.73754  ? 92   ILE A O   1 
ATOM   706  C  CB  . ILE A 1 92  ? -31.90134 21.83229 -12.75573 1.000 8.86238  ? 92   ILE A CB  1 
ATOM   707  C  CG1 . ILE A 1 92  ? -32.75283 22.07665 -14.00148 1.000 9.92370  ? 92   ILE A CG1 1 
ATOM   708  C  CG2 . ILE A 1 92  ? -32.02132 23.00429 -11.78313 1.000 9.79026  ? 92   ILE A CG2 1 
ATOM   709  C  CD1 . ILE A 1 92  ? -34.27508 22.04186 -13.72060 1.000 6.13561  ? 92   ILE A CD1 1 
ATOM   710  N  N   . ARG A 1 93  ? -28.86771 22.13816 -11.35412 1.000 8.45292  ? 93   ARG A N   1 
ATOM   711  C  CA  . ARG A 1 93  ? -28.28240 22.00255 -10.02652 1.000 8.63347  ? 93   ARG A CA  1 
ATOM   712  C  C   . ARG A 1 93  ? -28.98778 22.94601 -9.06251  1.000 9.34615  ? 93   ARG A C   1 
ATOM   713  O  O   . ARG A 1 93  ? -29.30311 24.08124 -9.41995  1.000 8.64053  ? 93   ARG A O   1 
ATOM   714  C  CB  . ARG A 1 93  ? -26.78163 22.31028 -10.03915 1.000 7.85789  ? 93   ARG A CB  1 
ATOM   715  C  CG  . ARG A 1 93  ? -26.00523 21.56164 -11.13084 1.000 7.14502  ? 93   ARG A CG  1 
ATOM   716  C  CD  . ARG A 1 93  ? -24.49631 21.70263 -10.92455 1.000 8.44228  ? 93   ARG A CD  1 
ATOM   717  N  NE  . ARG A 1 93  ? -24.05841 20.83643 -9.84171  1.000 8.41814  ? 93   ARG A NE  1 
ATOM   718  C  CZ  . ARG A 1 93  ? -23.84063 21.23350 -8.59262  1.000 11.70975 ? 93   ARG A CZ  1 
ATOM   719  N  NH1 . ARG A 1 93  ? -23.98123 22.51306 -8.25234  1.000 9.86741  ? 93   ARG A NH1 1 
ATOM   720  N  NH2 . ARG A 1 93  ? -23.45293 20.33975 -7.68645  1.000 9.92434  ? 93   ARG A NH2 1 
ATOM   721  N  N   . PHE A 1 94  ? -29.22717 22.48535 -7.83427  1.000 8.49750  ? 94   PHE A N   1 
ATOM   722  C  CA  . PHE A 1 94  ? -29.83362 23.32898 -6.81207  1.000 7.45577  ? 94   PHE A CA  1 
ATOM   723  C  C   . PHE A 1 94  ? -28.75054 23.86450 -5.87928  1.000 9.55260  ? 94   PHE A C   1 
ATOM   724  O  O   . PHE A 1 94  ? -28.10258 23.09606 -5.15219  1.000 8.95350  ? 94   PHE A O   1 
ATOM   725  C  CB  . PHE A 1 94  ? -30.89530 22.56126 -6.02243  1.000 8.36193  ? 94   PHE A CB  1 
ATOM   726  C  CG  . PHE A 1 94  ? -31.66760 23.42163 -5.06207  1.000 11.95591 ? 94   PHE A CG  1 
ATOM   727  C  CD1 . PHE A 1 94  ? -31.13418 23.75416 -3.81798  1.000 8.31345  ? 94   PHE A CD1 1 
ATOM   728  C  CD2 . PHE A 1 94  ? -32.91979 23.91348 -5.40543  1.000 9.82080  ? 94   PHE A CD2 1 
ATOM   729  C  CE1 . PHE A 1 94  ? -31.84390 24.54577 -2.92622  1.000 9.84723  ? 94   PHE A CE1 1 
ATOM   730  C  CE2 . PHE A 1 94  ? -33.63891 24.71641 -4.51657  1.000 9.27829  ? 94   PHE A CE2 1 
ATOM   731  C  CZ  . PHE A 1 94  ? -33.10471 25.03036 -3.27894  1.000 9.60831  ? 94   PHE A CZ  1 
ATOM   732  N  N   . HIS A 1 95  ? -28.56953 25.17817 -5.88181  1.000 8.88732  ? 95   HIS A N   1 
ATOM   733  C  CA  . HIS A 1 95  ? -27.65123 25.84216 -4.96204  1.000 11.48332 ? 95   HIS A CA  1 
ATOM   734  C  C   . HIS A 1 95  ? -28.45249 26.84413 -4.13847  1.000 7.76665  ? 95   HIS A C   1 
ATOM   735  O  O   . HIS A 1 95  ? -28.92445 27.84525 -4.68730  1.000 10.87253 ? 95   HIS A O   1 
ATOM   736  C  CB  . HIS A 1 95  ? -26.52334 26.53916 -5.72761  1.000 9.96906  ? 95   HIS A CB  1 
ATOM   737  C  CG  . HIS A 1 95  ? -25.44576 27.08135 -4.84136  1.000 11.69120 ? 95   HIS A CG  1 
ATOM   738  N  ND1 . HIS A 1 95  ? -24.40973 26.30102 -4.36480  1.000 12.51383 ? 95   HIS A ND1 1 
ATOM   739  C  CD2 . HIS A 1 95  ? -25.26251 28.31646 -4.31891  1.000 9.80004  ? 95   HIS A CD2 1 
ATOM   740  C  CE1 . HIS A 1 95  ? -23.63482 27.03764 -3.58918  1.000 15.59442 ? 95   HIS A CE1 1 
ATOM   741  N  NE2 . HIS A 1 95  ? -24.12590 28.26664 -3.55216  1.000 14.51377 ? 95   HIS A NE2 1 
ATOM   742  N  N   . THR A 1 96  ? -28.62285 26.59854 -2.82972  1.000 8.83092  ? 96   THR A N   1 
ATOM   743  C  CA  . THR A 1 96  ? -28.13756 25.43845 -2.06062  1.000 8.72897  ? 96   THR A CA  1 
ATOM   744  C  C   . THR A 1 96  ? -29.07109 25.26647 -0.85365  1.000 9.28643  ? 96   THR A C   1 
ATOM   745  O  O   . THR A 1 96  ? -29.67682 26.23761 -0.39219  1.000 9.67645  ? 96   THR A O   1 
ATOM   746  C  CB  . THR A 1 96  ? -26.66189 25.62052 -1.56912  1.000 9.33295  ? 96   THR A CB  1 
ATOM   747  O  OG1 . THR A 1 96  ? -26.31349 24.56952 -0.65723  1.000 9.13989  ? 96   THR A OG1 1 
ATOM   748  C  CG2 . THR A 1 96  ? -26.49725 26.93775 -0.85499  1.000 7.15330  ? 96   THR A CG2 1 
ATOM   749  N  N   . LEU A 1 97  ? -29.19868 24.04667 -0.32946  1.000 7.81042  ? 97   LEU A N   1 
ATOM   750  C  CA  . LEU A 1 97  ? -30.16651 23.82756 0.74121   1.000 6.88356  ? 97   LEU A CA  1 
ATOM   751  C  C   . LEU A 1 97  ? -29.71737 24.46699 2.04923   1.000 12.05292 ? 97   LEU A C   1 
ATOM   752  O  O   . LEU A 1 97  ? -30.55385 24.93789 2.82483   1.000 10.96879 ? 97   LEU A O   1 
ATOM   753  C  CB  . LEU A 1 97  ? -30.42039 22.33267 0.93901   1.000 8.84367  ? 97   LEU A CB  1 
ATOM   754  C  CG  . LEU A 1 97  ? -31.24079 21.65590 -0.17234  1.000 7.07110  ? 97   LEU A CG  1 
ATOM   755  C  CD1 . LEU A 1 97  ? -31.25082 20.13544 -0.00492  1.000 7.90446  ? 97   LEU A CD1 1 
ATOM   756  C  CD2 . LEU A 1 97  ? -32.64675 22.20935 -0.19551  1.000 5.19162  ? 97   LEU A CD2 1 
ATOM   757  N  N   . VAL A 1 98  ? -28.40870 24.48539 2.32260   1.000 10.26741 ? 98   VAL A N   1 
ATOM   758  C  CA  . VAL A 1 98  ? -27.88324 24.88762 3.62810   1.000 9.42709  ? 98   VAL A CA  1 
ATOM   759  C  C   . VAL A 1 98  ? -26.59246 25.67502 3.42787   1.000 10.90752 ? 98   VAL A C   1 
ATOM   760  O  O   . VAL A 1 98  ? -25.67529 25.21187 2.73544   1.000 10.90738 ? 98   VAL A O   1 
ATOM   761  C  CB  . VAL A 1 98  ? -27.61555 23.67475 4.54361   1.000 11.64048 ? 98   VAL A CB  1 
ATOM   762  C  CG1 . VAL A 1 98  ? -27.04111 24.13884 5.89343   1.000 12.46640 ? 98   VAL A CG1 1 
ATOM   763  C  CG2 . VAL A 1 98  ? -28.87371 22.87566 4.75027   1.000 8.35736  ? 98   VAL A CG2 1 
ATOM   764  N  N   . TRP A 1 99  ? -26.50673 26.84179 4.06821   1.000 8.51184  ? 99   TRP A N   1 
ATOM   765  C  CA  . TRP A 1 99  ? -25.34538 27.72036 3.95930   1.000 11.43554 ? 99   TRP A CA  1 
ATOM   766  C  C   . TRP A 1 99  ? -25.37487 28.70466 5.12126   1.000 13.39295 ? 99   TRP A C   1 
ATOM   767  O  O   . TRP A 1 99  ? -26.44830 29.07455 5.59770   1.000 15.22716 ? 99   TRP A O   1 
ATOM   768  C  CB  . TRP A 1 99  ? -25.35869 28.45809 2.61472   1.000 11.17923 ? 99   TRP A CB  1 
ATOM   769  C  CG  . TRP A 1 99  ? -24.09754 29.12028 2.21257   1.000 11.93657 ? 99   TRP A CG  1 
ATOM   770  C  CD1 . TRP A 1 99  ? -22.82239 28.82068 2.63039   1.000 13.56543 ? 99   TRP A CD1 1 
ATOM   771  C  CD2 . TRP A 1 99  ? -23.97137 30.18636 1.26500   1.000 14.58080 ? 99   TRP A CD2 1 
ATOM   772  N  NE1 . TRP A 1 99  ? -21.92046 29.65015 2.00740   1.000 12.87889 ? 99   TRP A NE1 1 
ATOM   773  C  CE2 . TRP A 1 99  ? -22.59788 30.49716 1.16563   1.000 11.71258 ? 99   TRP A CE2 1 
ATOM   774  C  CE3 . TRP A 1 99  ? -24.89151 30.91871 0.49802   1.000 13.92725 ? 99   TRP A CE3 1 
ATOM   775  C  CZ2 . TRP A 1 99  ? -22.12033 31.51660 0.33922   1.000 16.54556 ? 99   TRP A CZ2 1 
ATOM   776  C  CZ3 . TRP A 1 99  ? -24.41845 31.93154 -0.32258  1.000 18.32394 ? 99   TRP A CZ3 1 
ATOM   777  C  CH2 . TRP A 1 99  ? -23.03761 32.22170 -0.39474  1.000 19.64624 ? 99   TRP A CH2 1 
ATOM   778  N  N   . HIS A 1 100 ? -24.18848 29.12378 5.58031   1.000 12.31788 ? 100  HIS A N   1 
ATOM   779  C  CA  . HIS A 1 100 ? -24.10468 30.10642 6.65579   1.000 10.93267 ? 100  HIS A CA  1 
ATOM   780  C  C   . HIS A 1 100 ? -24.28720 31.53611 6.17397   1.000 16.88620 ? 100  HIS A C   1 
ATOM   781  O  O   . HIS A 1 100 ? -24.31261 32.45529 6.99832   1.000 16.41382 ? 100  HIS A O   1 
ATOM   782  C  CB  . HIS A 1 100 ? -22.76255 29.99168 7.37556   1.000 15.75668 ? 100  HIS A CB  1 
ATOM   783  C  CG  . HIS A 1 100 ? -21.60028 30.44820 6.54940   1.000 15.18751 ? 100  HIS A CG  1 
ATOM   784  N  ND1 . HIS A 1 100 ? -21.02377 29.66028 5.57289   1.000 10.18075 ? 100  HIS A ND1 1 
ATOM   785  C  CD2 . HIS A 1 100 ? -20.92760 31.62280 6.53356   1.000 12.33729 ? 100  HIS A CD2 1 
ATOM   786  C  CE1 . HIS A 1 100 ? -20.03372 30.32781 5.00523   1.000 12.90487 ? 100  HIS A CE1 1 
ATOM   787  N  NE2 . HIS A 1 100 ? -19.94565 31.51419 5.57859   1.000 12.37115 ? 100  HIS A NE2 1 
ATOM   788  N  N   . SER A 1 101 ? -24.40371 31.74962 4.86960   1.000 16.75172 ? 101  SER A N   1 
ATOM   789  C  CA  . SER A 1 101 ? -24.60059 33.07206 4.30171   1.000 17.05836 ? 101  SER A CA  1 
ATOM   790  C  C   . SER A 1 101 ? -25.89901 33.05890 3.49940   1.000 15.97012 ? 101  SER A C   1 
ATOM   791  O  O   . SER A 1 101 ? -26.37176 31.99906 3.08888   1.000 16.47913 ? 101  SER A O   1 
ATOM   792  C  CB  . SER A 1 101 ? -23.37807 33.45919 3.43954   1.000 16.77706 ? 101  SER A CB  1 
ATOM   793  O  OG  . SER A 1 101 ? -23.67196 34.49269 2.52716   1.000 21.99140 ? 101  SER A OG  1 
ATOM   794  N  N   . GLN A 1 102 ? -26.48374 34.23519 3.28133   1.000 18.30949 ? 102  GLN A N   1 
ATOM   795  C  CA  . GLN A 1 102 ? -27.78363 34.35755 2.61088   1.000 18.35224 ? 102  GLN A CA  1 
ATOM   796  C  C   . GLN A 1 102 ? -28.76423 33.31293 3.16719   1.000 20.82763 ? 102  GLN A C   1 
ATOM   797  O  O   . GLN A 1 102 ? -29.32590 32.46779 2.45405   1.000 10.56993 ? 102  GLN A O   1 
ATOM   798  C  CB  . GLN A 1 102 ? -27.63283 34.25824 1.08376   1.000 20.41319 ? 102  GLN A CB  1 
ATOM   799  C  CG  . GLN A 1 102 ? -26.98889 35.50645 0.41263   1.000 15.26158 ? 102  GLN A CG  1 
ATOM   800  C  CD  . GLN A 1 102 ? -26.75843 35.34272 -1.09295  1.000 25.17723 ? 102  GLN A CD  1 
ATOM   801  O  OE1 . GLN A 1 102 ? -25.67727 34.90692 -1.52998  1.000 18.55297 ? 102  GLN A OE1 1 
ATOM   802  N  NE2 . GLN A 1 102 ? -27.76844 35.70461 -1.89757  1.000 15.52428 ? 102  GLN A NE2 1 
ATOM   803  N  N   . VAL A 1 103 ? -28.93361 33.37939 4.48839   1.000 16.22495 ? 103  VAL A N   1 
ATOM   804  C  CA  . VAL A 1 103 ? -29.72356 32.42468 5.26289   1.000 17.06171 ? 103  VAL A CA  1 
ATOM   805  C  C   . VAL A 1 103 ? -30.55391 33.21121 6.27667   1.000 20.70028 ? 103  VAL A C   1 
ATOM   806  O  O   . VAL A 1 103 ? -30.01690 34.07119 6.98781   1.000 21.95291 ? 103  VAL A O   1 
ATOM   807  C  CB  . VAL A 1 103 ? -28.82340 31.37473 5.94769   1.000 21.48865 ? 103  VAL A CB  1 
ATOM   808  C  CG1 . VAL A 1 103 ? -27.80196 32.03772 6.87870   1.000 19.49555 ? 103  VAL A CG1 1 
ATOM   809  C  CG2 . VAL A 1 103 ? -29.65792 30.34396 6.71543   1.000 16.69494 ? 103  VAL A CG2 1 
ATOM   810  N  N   . PRO A 1 104 ? -31.85693 32.96323 6.37074   1.000 16.79026 ? 104  PRO A N   1 
ATOM   811  C  CA  . PRO A 1 104 ? -32.70325 33.82549 7.20920   1.000 21.22237 ? 104  PRO A CA  1 
ATOM   812  C  C   . PRO A 1 104 ? -32.41991 33.64365 8.69800   1.000 16.89830 ? 104  PRO A C   1 
ATOM   813  O  O   . PRO A 1 104 ? -32.22989 32.53021 9.19040   1.000 14.93403 ? 104  PRO A O   1 
ATOM   814  C  CB  . PRO A 1 104 ? -34.12722 33.38611 6.84203   1.000 19.04101 ? 104  PRO A CB  1 
ATOM   815  C  CG  . PRO A 1 104 ? -33.98896 32.00885 6.30936   1.000 17.50157 ? 104  PRO A CG  1 
ATOM   816  C  CD  . PRO A 1 104 ? -32.63037 31.93689 5.65237   1.000 17.48226 ? 104  PRO A CD  1 
ATOM   817  N  N   . GLN A 1 105 ? -32.39538 34.76557 9.41948   1.000 20.02969 ? 105  GLN A N   1 
ATOM   818  C  CA  . GLN A 1 105 ? -32.04268 34.71928 10.83336  1.000 19.71001 ? 105  GLN A CA  1 
ATOM   819  C  C   . GLN A 1 105 ? -33.09582 34.02428 11.68922  1.000 18.12639 ? 105  GLN A C   1 
ATOM   820  O  O   . GLN A 1 105 ? -32.76131 33.54418 12.77731  1.000 17.74433 ? 105  GLN A O   1 
ATOM   821  C  CB  . GLN A 1 105 ? -31.79082 36.13661 11.35975  1.000 22.94869 ? 105  GLN A CB  1 
ATOM   822  C  CG  . GLN A 1 105 ? -30.68514 36.85608 10.60884  1.000 31.83569 ? 105  GLN A CG  1 
ATOM   823  C  CD  . GLN A 1 105 ? -29.34241 36.15674 10.75529  1.000 46.35489 ? 105  GLN A CD  1 
ATOM   824  O  OE1 . GLN A 1 105 ? -28.92165 35.39280 9.87328   1.000 41.73832 ? 105  GLN A OE1 1 
ATOM   825  N  NE2 . GLN A 1 105 ? -28.66040 36.41293 11.87027  1.000 51.71223 ? 105  GLN A NE2 1 
ATOM   826  N  N   . TRP A 1 106 ? -34.35133 33.94803 11.22732  1.000 16.92458 ? 106  TRP A N   1 
ATOM   827  C  CA  . TRP A 1 106 ? -35.38207 33.27983 12.02031  1.000 18.08611 ? 106  TRP A CA  1 
ATOM   828  C  C   . TRP A 1 106 ? -35.03295 31.83176 12.32464  1.000 19.07042 ? 106  TRP A C   1 
ATOM   829  O  O   . TRP A 1 106 ? -35.54233 31.28962 13.30822  1.000 17.89089 ? 106  TRP A O   1 
ATOM   830  C  CB  . TRP A 1 106 ? -36.75788 33.34342 11.32491  1.000 18.47631 ? 106  TRP A CB  1 
ATOM   831  C  CG  . TRP A 1 106 ? -36.86947 32.56396 10.03346  1.000 14.21110 ? 106  TRP A CG  1 
ATOM   832  C  CD1 . TRP A 1 106 ? -36.80061 33.07121 8.76901   1.000 15.06999 ? 106  TRP A CD1 1 
ATOM   833  C  CD2 . TRP A 1 106 ? -37.09229 31.15438 9.88662   1.000 13.98130 ? 106  TRP A CD2 1 
ATOM   834  N  NE1 . TRP A 1 106 ? -36.95564 32.06264 7.84119   1.000 13.32500 ? 106  TRP A NE1 1 
ATOM   835  C  CE2 . TRP A 1 106 ? -37.12937 30.87717 8.50361   1.000 14.42010 ? 106  TRP A CE2 1 
ATOM   836  C  CE3 . TRP A 1 106 ? -37.26410 30.09872 10.78903  1.000 16.81166 ? 106  TRP A CE3 1 
ATOM   837  C  CZ2 . TRP A 1 106 ? -37.33606 29.59371 8.00336   1.000 12.16416 ? 106  TRP A CZ2 1 
ATOM   838  C  CZ3 . TRP A 1 106 ? -37.45315 28.82259 10.28877  1.000 15.25592 ? 106  TRP A CZ3 1 
ATOM   839  C  CH2 . TRP A 1 106 ? -37.48368 28.58215 8.90870   1.000 13.29995 ? 106  TRP A CH2 1 
ATOM   840  N  N   . PHE A 1 107 ? -34.18125 31.19253 11.50795  1.000 16.65470 ? 107  PHE A N   1 
ATOM   841  C  CA  . PHE A 1 107 ? -33.77664 29.81110 11.78760  1.000 16.00051 ? 107  PHE A CA  1 
ATOM   842  C  C   . PHE A 1 107 ? -33.19700 29.66817 13.19173  1.000 15.38024 ? 107  PHE A C   1 
ATOM   843  O  O   . PHE A 1 107 ? -33.39564 28.64341 13.85531  1.000 18.14947 ? 107  PHE A O   1 
ATOM   844  C  CB  . PHE A 1 107 ? -32.72678 29.34464 10.77696  1.000 15.39284 ? 107  PHE A CB  1 
ATOM   845  C  CG  . PHE A 1 107 ? -33.28610 28.63938 9.55845   1.000 16.38169 ? 107  PHE A CG  1 
ATOM   846  C  CD1 . PHE A 1 107 ? -33.97826 27.44301 9.67485   1.000 15.66573 ? 107  PHE A CD1 1 
ATOM   847  C  CD2 . PHE A 1 107 ? -33.08091 29.16626 8.29169   1.000 17.62195 ? 107  PHE A CD2 1 
ATOM   848  C  CE1 . PHE A 1 107 ? -34.47041 26.79438 8.54700   1.000 16.14495 ? 107  PHE A CE1 1 
ATOM   849  C  CE2 . PHE A 1 107 ? -33.56605 28.52130 7.15877   1.000 15.46028 ? 107  PHE A CE2 1 
ATOM   850  C  CZ  . PHE A 1 107 ? -34.26015 27.34034 7.28515   1.000 15.06667 ? 107  PHE A CZ  1 
ATOM   851  N  N   . PHE A 1 108 ? -32.43922 30.66409 13.64263  1.000 14.67316 ? 108  PHE A N   1 
ATOM   852  C  CA  . PHE A 1 108 ? -31.57495 30.51692 14.80836  1.000 16.82223 ? 108  PHE A CA  1 
ATOM   853  C  C   . PHE A 1 108 ? -32.09976 31.26852 16.02929  1.000 19.92717 ? 108  PHE A C   1 
ATOM   854  O  O   . PHE A 1 108 ? -31.33102 31.54143 16.95784  1.000 21.51138 ? 108  PHE A O   1 
ATOM   855  C  CB  . PHE A 1 108 ? -30.15488 30.98106 14.47048  1.000 15.34033 ? 108  PHE A CB  1 
ATOM   856  C  CG  . PHE A 1 108 ? -29.64604 30.45861 13.14965  1.000 15.36445 ? 108  PHE A CG  1 
ATOM   857  C  CD1 . PHE A 1 108 ? -29.50457 29.09560 12.94023  1.000 14.83514 ? 108  PHE A CD1 1 
ATOM   858  C  CD2 . PHE A 1 108 ? -29.32725 31.33028 12.11932  1.000 15.61536 ? 108  PHE A CD2 1 
ATOM   859  C  CE1 . PHE A 1 108 ? -29.03819 28.60671 11.73317  1.000 16.40113 ? 108  PHE A CE1 1 
ATOM   860  C  CE2 . PHE A 1 108 ? -28.85827 30.84953 10.89957  1.000 21.09069 ? 108  PHE A CE2 1 
ATOM   861  C  CZ  . PHE A 1 108 ? -28.71545 29.48292 10.70931  1.000 19.26806 ? 108  PHE A CZ  1 
ATOM   862  N  N   . LEU A 1 109 ? -33.38588 31.61581 16.03970  1.000 17.98381 ? 109  LEU A N   1 
ATOM   863  C  CA  . LEU A 1 109 ? -34.02821 32.26518 17.17600  1.000 21.12283 ? 109  LEU A CA  1 
ATOM   864  C  C   . LEU A 1 109 ? -34.82143 31.23864 17.97135  1.000 22.10151 ? 109  LEU A C   1 
ATOM   865  O  O   . LEU A 1 109 ? -35.49739 30.38118 17.39124  1.000 24.02455 ? 109  LEU A O   1 
ATOM   866  C  CB  . LEU A 1 109 ? -34.95866 33.38512 16.71135  1.000 21.71222 ? 109  LEU A CB  1 
ATOM   867  C  CG  . LEU A 1 109 ? -34.32244 34.58484 16.02215  1.000 23.13255 ? 109  LEU A CG  1 
ATOM   868  C  CD1 . LEU A 1 109 ? -35.38874 35.62971 15.78757  1.000 20.84344 ? 109  LEU A CD1 1 
ATOM   869  C  CD2 . LEU A 1 109 ? -33.17487 35.14090 16.85213  1.000 24.08976 ? 109  LEU A CD2 1 
ATOM   870  N  N   . ASP A 1 110 ? -34.74013 31.32569 19.29952  1.000 25.17692 ? 110  ASP A N   1 
ATOM   871  C  CA  . ASP A 1 110 ? -35.47360 30.39788 20.14791  1.000 26.94999 ? 110  ASP A CA  1 
ATOM   872  C  C   . ASP A 1 110 ? -36.93806 30.82980 20.25736  1.000 26.53076 ? 110  ASP A C   1 
ATOM   873  O  O   . ASP A 1 110 ? -37.37093 31.81321 19.65206  1.000 24.37466 ? 110  ASP A O   1 
ATOM   874  C  CB  . ASP A 1 110 ? -34.80215 30.26961 21.52274  1.000 32.32936 ? 110  ASP A CB  1 
ATOM   875  C  CG  . ASP A 1 110 ? -34.84919 31.56599 22.35707  1.000 31.89527 ? 110  ASP A CG  1 
ATOM   876  O  OD1 . ASP A 1 110 ? -35.64762 32.48408 22.06815  1.000 28.24773 ? 110  ASP A OD1 1 
ATOM   877  O  OD2 . ASP A 1 110 ? -34.05746 31.65963 23.32103  1.000 22.63890 ? 110  ASP A OD2 1 
ATOM   878  N  N   . LYS A 1 111 ? -37.70818 30.09248 21.06319  1.000 30.47052 ? 111  LYS A N   1 
ATOM   879  C  CA  . LYS A 1 111 ? -39.14785 30.31889 21.13619  1.000 35.37083 ? 111  LYS A CA  1 
ATOM   880  C  C   . LYS A 1 111 ? -39.50372 31.69446 21.68579  1.000 34.16668 ? 111  LYS A C   1 
ATOM   881  O  O   . LYS A 1 111 ? -40.60179 32.19101 21.41162  1.000 37.97296 ? 111  LYS A O   1 
ATOM   882  C  CB  . LYS A 1 111 ? -39.80323 29.22760 21.97947  1.000 34.56047 ? 111  LYS A CB  1 
ATOM   883  C  CG  . LYS A 1 111 ? -39.78986 27.85468 21.31324  1.000 35.36749 ? 111  LYS A CG  1 
ATOM   884  C  CD  . LYS A 1 111 ? -40.92426 27.72197 20.29931  1.000 45.88748 ? 111  LYS A CD  1 
ATOM   885  C  CE  . LYS A 1 111 ? -40.89534 26.37781 19.58132  1.000 44.57472 ? 111  LYS A CE  1 
ATOM   886  N  NZ  . LYS A 1 111 ? -40.88275 25.23223 20.53480  1.000 46.24959 ? 111  LYS A NZ  1 
ATOM   887  N  N   . GLU A 1 112 ? -38.60746 32.32584 22.43758  1.000 29.11397 ? 112  GLU A N   1 
ATOM   888  C  CA  . GLU A 1 112 ? -38.82738 33.67960 22.92842  1.000 30.06254 ? 112  GLU A CA  1 
ATOM   889  C  C   . GLU A 1 112 ? -38.18431 34.72293 22.03760  1.000 30.82625 ? 112  GLU A C   1 
ATOM   890  O  O   . GLU A 1 112 ? -38.06549 35.88495 22.44277  1.000 32.57213 ? 112  GLU A O   1 
ATOM   891  C  CB  . GLU A 1 112 ? -38.31184 33.81840 24.37117  1.000 36.52832 ? 112  GLU A CB  1 
ATOM   892  C  CG  . GLU A 1 112 ? -38.58271 32.60613 25.27661  1.000 39.75881 ? 112  GLU A CG  1 
ATOM   893  C  CD  . GLU A 1 112 ? -40.01029 32.06090 25.16160  1.000 53.23471 ? 112  GLU A CD  1 
ATOM   894  O  OE1 . GLU A 1 112 ? -40.17687 30.82624 25.29830  1.000 57.41255 ? 112  GLU A OE1 1 
ATOM   895  O  OE2 . GLU A 1 112 ? -40.96393 32.85271 24.95520  1.000 55.60151 ? 112  GLU A OE2 1 
ATOM   896  N  N   . GLY A 1 113 ? -37.76339 34.33732 20.83517  1.000 26.47492 ? 113  GLY A N   1 
ATOM   897  C  CA  . GLY A 1 113 ? -37.19444 35.27838 19.90008  1.000 24.07176 ? 113  GLY A CA  1 
ATOM   898  C  C   . GLY A 1 113 ? -35.75487 35.64160 20.16512  1.000 29.16676 ? 113  GLY A C   1 
ATOM   899  O  O   . GLY A 1 113 ? -35.25282 36.59477 19.55770  1.000 29.45589 ? 113  GLY A O   1 
ATOM   900  N  N   . LYS A 1 114 ? -35.05987 34.90058 21.05891  1.000 25.56275 ? 114  LYS A N   1 
ATOM   901  C  CA  . LYS A 1 114 ? -33.68265 35.25748 21.36478  1.000 30.20325 ? 114  LYS A CA  1 
ATOM   902  C  C   . LYS A 1 114 ? -32.70874 34.37011 20.59309  1.000 27.00318 ? 114  LYS A C   1 
ATOM   903  O  O   . LYS A 1 114 ? -33.03899 33.22866 20.24299  1.000 28.13243 ? 114  LYS A O   1 
ATOM   904  C  CB  . LYS A 1 114 ? -33.42312 35.12367 22.87037  1.000 36.33685 ? 114  LYS A CB  1 
ATOM   905  C  CG  . LYS A 1 114 ? -33.85186 36.34882 23.69054  1.000 40.29525 ? 114  LYS A CG  1 
ATOM   906  C  CD  . LYS A 1 114 ? -33.14656 36.39039 25.05117  1.000 50.95794 ? 114  LYS A CD  1 
ATOM   907  C  CE  . LYS A 1 114 ? -31.68671 36.79917 24.91151  1.000 51.19664 ? 114  LYS A CE  1 
ATOM   908  N  NZ  . LYS A 1 114 ? -30.73175 35.92146 25.65560  1.000 48.99758 ? 114  LYS A NZ  1 
ATOM   909  N  N   . PRO A 1 115 ? -31.50604 34.86577 20.30759  1.000 26.40417 ? 115  PRO A N   1 
ATOM   910  C  CA  . PRO A 1 115 ? -30.52684 34.04980 19.57415  1.000 25.87901 ? 115  PRO A CA  1 
ATOM   911  C  C   . PRO A 1 115 ? -30.19178 32.77071 20.32603  1.000 30.76038 ? 115  PRO A C   1 
ATOM   912  O  O   . PRO A 1 115 ? -29.83264 32.80139 21.50544  1.000 34.14139 ? 115  PRO A O   1 
ATOM   913  C  CB  . PRO A 1 115 ? -29.30892 34.97530 19.46052  1.000 32.73241 ? 115  PRO A CB  1 
ATOM   914  C  CG  . PRO A 1 115 ? -29.87698 36.36048 19.57555  1.000 33.73969 ? 115  PRO A CG  1 
ATOM   915  C  CD  . PRO A 1 115 ? -31.01708 36.23605 20.54219  1.000 33.37524 ? 115  PRO A CD  1 
ATOM   916  N  N   . MET A 1 116 ? -30.31459 31.63640 19.62402  1.000 24.50829 ? 116  MET A N   1 
ATOM   917  C  CA  . MET A 1 116 ? -30.02159 30.34005 20.22626  1.000 24.19982 ? 116  MET A CA  1 
ATOM   918  C  C   . MET A 1 116 ? -28.56621 30.22540 20.66028  1.000 29.20286 ? 116  MET A C   1 
ATOM   919  O  O   . MET A 1 116 ? -28.26145 29.48009 21.59833  1.000 27.12835 ? 116  MET A O   1 
ATOM   920  C  CB  . MET A 1 116 ? -30.34127 29.20484 19.24960  1.000 19.80112 ? 116  MET A CB  1 
ATOM   921  C  CG  . MET A 1 116 ? -31.82135 29.00421 18.93132  1.000 23.69659 ? 116  MET A CG  1 
ATOM   922  S  SD  . MET A 1 116 ? -32.05197 27.73304 17.66740  1.000 20.79664 ? 116  MET A SD  1 
ATOM   923  C  CE  . MET A 1 116 ? -33.77819 27.31651 17.88721  1.000 17.56223 ? 116  MET A CE  1 
ATOM   924  N  N   . VAL A 1 117 ? -27.65180 30.91590 19.97181  1.000 24.60728 ? 117  VAL A N   1 
ATOM   925  C  CA  . VAL A 1 117 ? -26.23668 30.79069 20.29573  1.000 27.56615 ? 117  VAL A CA  1 
ATOM   926  C  C   . VAL A 1 117 ? -25.93244 31.31380 21.69058  1.000 29.70158 ? 117  VAL A C   1 
ATOM   927  O  O   . VAL A 1 117 ? -24.94847 30.89050 22.30285  1.000 33.94240 ? 117  VAL A O   1 
ATOM   928  C  CB  . VAL A 1 117 ? -25.36685 31.51640 19.24737  1.000 28.81350 ? 117  VAL A CB  1 
ATOM   929  C  CG1 . VAL A 1 117 ? -25.36373 30.75332 17.92670  1.000 25.43061 ? 117  VAL A CG1 1 
ATOM   930  C  CG2 . VAL A 1 117 ? -25.84695 32.94902 19.05727  1.000 28.64365 ? 117  VAL A CG2 1 
ATOM   931  N  N   . ASN A 1 118 ? -26.76549 32.21308 22.21902  1.000 30.32207 ? 118  ASN A N   1 
ATOM   932  C  CA  . ASN A 1 118 ? -26.54494 32.80356 23.53463  1.000 27.88440 ? 118  ASN A CA  1 
ATOM   933  C  C   . ASN A 1 118 ? -27.06649 31.95142 24.68483  1.000 33.71073 ? 118  ASN A C   1 
ATOM   934  O  O   . ASN A 1 118 ? -26.83501 32.30450 25.84536  1.000 43.48710 ? 118  ASN A O   1 
ATOM   935  C  CB  . ASN A 1 118 ? -27.20059 34.18072 23.61195  1.000 30.30872 ? 118  ASN A CB  1 
ATOM   936  C  CG  . ASN A 1 118 ? -26.61346 35.16359 22.62568  1.000 29.75917 ? 118  ASN A CG  1 
ATOM   937  O  OD1 . ASN A 1 118 ? -25.48874 34.99469 22.16097  1.000 39.02822 ? 118  ASN A OD1 1 
ATOM   938  N  ND2 . ASN A 1 118 ? -27.37190 36.20410 22.30317  1.000 28.38724 ? 118  ASN A ND2 1 
ATOM   939  N  N   . GLU A 1 119 ? -27.75813 30.85204 24.41193  1.000 33.13675 ? 119  GLU A N   1 
ATOM   940  C  CA  . GLU A 1 119 ? -28.33179 30.05853 25.48984  1.000 33.93454 ? 119  GLU A CA  1 
ATOM   941  C  C   . GLU A 1 119 ? -27.23568 29.35782 26.28417  1.000 35.25462 ? 119  GLU A C   1 
ATOM   942  O  O   . GLU A 1 119 ? -26.37950 28.67666 25.71204  1.000 34.96089 ? 119  GLU A O   1 
ATOM   943  C  CB  . GLU A 1 119 ? -29.31174 29.03406 24.92660  1.000 29.27032 ? 119  GLU A CB  1 
ATOM   944  C  CG  . GLU A 1 119 ? -29.99358 28.19242 25.97910  1.000 29.46813 ? 119  GLU A CG  1 
ATOM   945  C  CD  . GLU A 1 119 ? -30.70422 29.03736 27.02327  1.000 39.09298 ? 119  GLU A CD  1 
ATOM   946  O  OE1 . GLU A 1 119 ? -31.45821 29.95930 26.64258  1.000 31.62253 ? 119  GLU A OE1 1 
ATOM   947  O  OE2 . GLU A 1 119 ? -30.49924 28.78271 28.22963  1.000 43.79790 ? 119  GLU A OE2 1 
ATOM   948  N  N   . THR A 1 120 ? -27.27304 29.51432 27.60886  1.000 37.71974 ? 120  THR A N   1 
ATOM   949  C  CA  . THR A 1 120 ? -26.32504 28.86238 28.50950  1.000 38.73498 ? 120  THR A CA  1 
ATOM   950  C  C   . THR A 1 120 ? -26.82839 27.53735 29.07399  1.000 40.83325 ? 120  THR A C   1 
ATOM   951  O  O   . THR A 1 120 ? -26.01269 26.66181 29.38103  1.000 41.03094 ? 120  THR A O   1 
ATOM   952  C  CB  . THR A 1 120 ? -25.97332 29.79229 29.68170  1.000 40.58787 ? 120  THR A CB  1 
ATOM   953  O  OG1 . THR A 1 120 ? -27.05320 29.80041 30.62270  1.000 47.06588 ? 120  THR A OG1 1 
ATOM   954  C  CG2 . THR A 1 120 ? -25.72704 31.22083 29.20223  1.000 35.68398 ? 120  THR A CG2 1 
ATOM   955  N  N   . ASP A 1 121 ? -28.13978 27.36656 29.22317  1.000 37.51037 ? 121  ASP A N   1 
ATOM   956  C  CA  . ASP A 1 121 ? -28.69858 26.16325 29.84358  1.000 35.21567 ? 121  ASP A CA  1 
ATOM   957  C  C   . ASP A 1 121 ? -28.55636 24.95845 28.91951  1.000 41.55427 ? 121  ASP A C   1 
ATOM   958  O  O   . ASP A 1 121 ? -29.08254 24.98652 27.79845  1.000 39.49041 ? 121  ASP A O   1 
ATOM   959  C  CB  . ASP A 1 121 ? -30.17214 26.40334 30.18688  1.000 41.59085 ? 121  ASP A CB  1 
ATOM   960  C  CG  . ASP A 1 121 ? -30.79560 25.27205 31.00166  1.000 38.82044 ? 121  ASP A CG  1 
ATOM   961  O  OD1 . ASP A 1 121 ? -30.56392 24.08376 30.70698  1.000 42.62681 ? 121  ASP A OD1 1 
ATOM   962  O  OD2 . ASP A 1 121 ? -31.54833 25.58137 31.94401  1.000 53.15807 ? 121  ASP A OD2 1 
ATOM   963  N  N   . PRO A 1 122 ? -27.89720 23.87632 29.34976  1.000 38.52452 ? 122  PRO A N   1 
ATOM   964  C  CA  . PRO A 1 122 ? -27.75428 22.70415 28.46859  1.000 37.70610 ? 122  PRO A CA  1 
ATOM   965  C  C   . PRO A 1 122 ? -29.06985 22.04063 28.10525  1.000 38.51958 ? 122  PRO A C   1 
ATOM   966  O  O   . PRO A 1 122 ? -29.18982 21.50110 26.99663  1.000 37.69632 ? 122  PRO A O   1 
ATOM   967  C  CB  . PRO A 1 122 ? -26.85522 21.75873 29.28133  1.000 36.37079 ? 122  PRO A CB  1 
ATOM   968  C  CG  . PRO A 1 122 ? -26.99025 22.21667 30.69580  1.000 36.78762 ? 122  PRO A CG  1 
ATOM   969  C  CD  . PRO A 1 122 ? -27.19257 23.69685 30.63058  1.000 40.74859 ? 122  PRO A CD  1 
ATOM   970  N  N   . VAL A 1 123 ? -30.05497 22.04335 29.00477  1.000 35.71296 ? 123  VAL A N   1 
ATOM   971  C  CA  . VAL A 1 123 ? -31.36980 21.50794 28.65511  1.000 39.28692 ? 123  VAL A CA  1 
ATOM   972  C  C   . VAL A 1 123 ? -31.97810 22.31696 27.51922  1.000 34.72171 ? 123  VAL A C   1 
ATOM   973  O  O   . VAL A 1 123 ? -32.51843 21.76091 26.55410  1.000 32.64729 ? 123  VAL A O   1 
ATOM   974  C  CB  . VAL A 1 123 ? -32.29712 21.48579 29.88776  1.000 44.46184 ? 123  VAL A CB  1 
ATOM   975  C  CG1 . VAL A 1 123 ? -33.69438 20.99552 29.49837  1.000 34.19380 ? 123  VAL A CG1 1 
ATOM   976  C  CG2 . VAL A 1 123 ? -31.71494 20.60561 30.98163  1.000 35.51021 ? 123  VAL A CG2 1 
ATOM   977  N  N   . LYS A 1 124 ? -31.90048 23.64672 27.61696  1.000 33.01767 ? 124  LYS A N   1 
ATOM   978  C  CA  . LYS A 1 124 ? -32.48725 24.50240 26.59774  1.000 30.97145 ? 124  LYS A CA  1 
ATOM   979  C  C   . LYS A 1 124 ? -31.66427 24.48467 25.31487  1.000 35.81795 ? 124  LYS A C   1 
ATOM   980  O  O   . LYS A 1 124 ? -32.21120 24.67261 24.22098  1.000 31.22058 ? 124  LYS A O   1 
ATOM   981  C  CB  . LYS A 1 124 ? -32.61820 25.93055 27.12241  1.000 31.98321 ? 124  LYS A CB  1 
ATOM   982  C  CG  . LYS A 1 124 ? -33.59477 26.08046 28.27516  1.000 41.43927 ? 124  LYS A CG  1 
ATOM   983  C  CD  . LYS A 1 124 ? -33.70442 27.53495 28.72458  1.000 46.31635 ? 124  LYS A CD  1 
ATOM   984  C  CE  . LYS A 1 124 ? -34.65275 27.68115 29.91229  1.000 51.21939 ? 124  LYS A CE  1 
ATOM   985  N  NZ  . LYS A 1 124 ? -35.01374 29.10340 30.17607  1.000 48.97344 ? 124  LYS A NZ  1 
ATOM   986  N  N   . ARG A 1 125 ? -30.35365 24.27173 25.42809  1.000 30.70483 ? 125  ARG A N   1 
ATOM   987  C  CA  . ARG A 1 125 ? -29.53516 24.16497 24.23075  1.000 30.59963 ? 125  ARG A CA  1 
ATOM   988  C  C   . ARG A 1 125 ? -29.91301 22.92789 23.43558  1.000 31.14138 ? 125  ARG A C   1 
ATOM   989  O  O   . ARG A 1 125 ? -29.95089 22.96458 22.20034  1.000 24.69844 ? 125  ARG A O   1 
ATOM   990  C  CB  . ARG A 1 125 ? -28.05477 24.15003 24.60463  1.000 28.14728 ? 125  ARG A CB  1 
ATOM   991  C  CG  . ARG A 1 125 ? -27.52564 25.51552 25.01974  1.000 34.13428 ? 125  ARG A CG  1 
ATOM   992  C  CD  . ARG A 1 125 ? -26.00826 25.54035 25.03976  1.000 33.97862 ? 125  ARG A CD  1 
ATOM   993  N  NE  . ARG A 1 125 ? -25.45288 25.31471 23.71179  1.000 32.59793 ? 125  ARG A NE  1 
ATOM   994  C  CZ  . ARG A 1 125 ? -25.25938 26.27594 22.81640  1.000 35.27497 ? 125  ARG A CZ  1 
ATOM   995  N  NH1 . ARG A 1 125 ? -25.57242 27.53688 23.10716  1.000 32.41975 ? 125  ARG A NH1 1 
ATOM   996  N  NH2 . ARG A 1 125 ? -24.73966 25.97770 21.63262  1.000 35.83272 ? 125  ARG A NH2 1 
ATOM   997  N  N   . GLU A 1 126 ? -30.21932 21.82967 24.12756  1.000 28.65329 ? 126  GLU A N   1 
ATOM   998  C  CA  . GLU A 1 126 ? -30.64063 20.62862 23.42517  1.000 28.27388 ? 126  GLU A CA  1 
ATOM   999  C  C   . GLU A 1 126 ? -31.99108 20.83843 22.76049  1.000 30.26675 ? 126  GLU A C   1 
ATOM   1000 O  O   . GLU A 1 126 ? -32.20475 20.39899 21.62449  1.000 27.02622 ? 126  GLU A O   1 
ATOM   1001 C  CB  . GLU A 1 126 ? -30.68778 19.43908 24.38044  1.000 28.74567 ? 126  GLU A CB  1 
ATOM   1002 C  CG  . GLU A 1 126 ? -31.11894 18.14890 23.71244  1.000 30.34408 ? 126  GLU A CG  1 
ATOM   1003 C  CD  . GLU A 1 126 ? -30.16303 17.71558 22.61916  1.000 29.46402 ? 126  GLU A CD  1 
ATOM   1004 O  OE1 . GLU A 1 126 ? -28.99080 18.14293 22.64508  1.000 32.35430 ? 126  GLU A OE1 1 
ATOM   1005 O  OE2 . GLU A 1 126 ? -30.58238 16.94570 21.73097  1.000 32.85067 ? 126  GLU A OE2 1 
ATOM   1006 N  N   . GLN A 1 127 ? -32.91183 21.51221 23.44972  1.000 25.90264 ? 127  GLN A N   1 
ATOM   1007 C  CA  . GLN A 1 127 ? -34.19602 21.82831 22.83634  1.000 30.28582 ? 127  GLN A CA  1 
ATOM   1008 C  C   . GLN A 1 127 ? -34.01409 22.71576 21.61083  1.000 26.85428 ? 127  GLN A C   1 
ATOM   1009 O  O   . GLN A 1 127 ? -34.72878 22.56413 20.61407  1.000 25.60957 ? 127  GLN A O   1 
ATOM   1010 C  CB  . GLN A 1 127 ? -35.11442 22.50524 23.85325  1.000 26.62405 ? 127  GLN A CB  1 
ATOM   1011 C  CG  . GLN A 1 127 ? -35.52082 21.61156 25.00797  1.000 29.71978 ? 127  GLN A CG  1 
ATOM   1012 C  CD  . GLN A 1 127 ? -36.23648 22.37674 26.11138  1.000 37.56918 ? 127  GLN A CD  1 
ATOM   1013 O  OE1 . GLN A 1 127 ? -36.18761 23.60692 26.16583  1.000 37.79133 ? 127  GLN A OE1 1 
ATOM   1014 N  NE2 . GLN A 1 127 ? -36.90120 21.64754 26.99960  1.000 40.68031 ? 127  GLN A NE2 1 
ATOM   1015 N  N   . ASN A 1 128 ? -33.07062 23.65680 21.66841  1.000 24.42668 ? 128  ASN A N   1 
ATOM   1016 C  CA  . ASN A 1 128 ? -32.84261 24.51369 20.51433  1.000 24.07517 ? 128  ASN A CA  1 
ATOM   1017 C  C   . ASN A 1 128 ? -32.25408 23.71882 19.36403  1.000 24.76570 ? 128  ASN A C   1 
ATOM   1018 O  O   . ASN A 1 128 ? -32.57623 23.97353 18.19937  1.000 21.82663 ? 128  ASN A O   1 
ATOM   1019 C  CB  . ASN A 1 128 ? -31.93437 25.67953 20.88479  1.000 22.77944 ? 128  ASN A CB  1 
ATOM   1020 C  CG  . ASN A 1 128 ? -32.64170 26.70560 21.72352  1.000 23.85434 ? 128  ASN A CG  1 
ATOM   1021 O  OD1 . ASN A 1 128 ? -33.86755 26.77922 21.71261  1.000 28.64516 ? 128  ASN A OD1 1 
ATOM   1022 N  ND2 . ASN A 1 128 ? -31.87698 27.50246 22.47071  1.000 24.43501 ? 128  ASN A ND2 1 
ATOM   1023 N  N   . LYS A 1 129 ? -31.40260 22.74041 19.67259  1.000 23.00860 ? 129  LYS A N   1 
ATOM   1024 C  CA  . LYS A 1 129 ? -30.85237 21.89677 18.62314  1.000 23.37807 ? 129  LYS A CA  1 
ATOM   1025 C  C   . LYS A 1 129 ? -31.96352 21.15435 17.89621  1.000 26.11002 ? 129  LYS A C   1 
ATOM   1026 O  O   . LYS A 1 129 ? -31.99624 21.10886 16.66219  1.000 20.17722 ? 129  LYS A O   1 
ATOM   1027 C  CB  . LYS A 1 129 ? -29.84302 20.91528 19.20944  1.000 18.91204 ? 129  LYS A CB  1 
ATOM   1028 C  CG  . LYS A 1 129 ? -29.34896 19.88584 18.21707  1.000 19.34678 ? 129  LYS A CG  1 
ATOM   1029 C  CD  . LYS A 1 129 ? -28.37150 18.91751 18.86946  1.000 21.20868 ? 129  LYS A CD  1 
ATOM   1030 C  CE  . LYS A 1 129 ? -28.09944 17.71778 17.97702  1.000 23.74712 ? 129  LYS A CE  1 
ATOM   1031 N  NZ  . LYS A 1 129 ? -26.95047 16.88076 18.47289  1.000 22.90644 ? 129  LYS A NZ  1 
ATOM   1032 N  N   . GLN A 1 130 ? -32.89383 20.57422 18.64648  1.000 21.58139 ? 130  GLN A N   1 
ATOM   1033 C  CA  . GLN A 1 130 ? -33.95429 19.80780 18.00932  1.000 22.40460 ? 130  GLN A CA  1 
ATOM   1034 C  C   . GLN A 1 130 ? -34.88945 20.71586 17.22176  1.000 19.96015 ? 130  GLN A C   1 
ATOM   1035 O  O   . GLN A 1 130 ? -35.36809 20.34012 16.14588  1.000 20.36531 ? 130  GLN A O   1 
ATOM   1036 C  CB  . GLN A 1 130 ? -34.71343 19.00634 19.06358  1.000 30.44792 ? 130  GLN A CB  1 
ATOM   1037 C  CG  . GLN A 1 130 ? -33.84535 17.97077 19.76143  1.000 27.38315 ? 130  GLN A CG  1 
ATOM   1038 C  CD  . GLN A 1 130 ? -33.15886 17.02892 18.77329  1.000 30.36476 ? 130  GLN A CD  1 
ATOM   1039 O  OE1 . GLN A 1 130 ? -33.71473 16.69306 17.72201  1.000 35.75120 ? 130  GLN A OE1 1 
ATOM   1040 N  NE2 . GLN A 1 130 ? -31.94737 16.59769 19.10961  1.000 28.59487 ? 130  GLN A NE2 1 
ATOM   1041 N  N   . LEU A 1 131 ? -35.14898 21.91705 17.73837  1.000 17.81322 ? 131  LEU A N   1 
ATOM   1042 C  CA  . LEU A 1 131 ? -35.96012 22.88507 17.01508  1.000 22.23908 ? 131  LEU A CA  1 
ATOM   1043 C  C   . LEU A 1 131 ? -35.29435 23.28647 15.69853  1.000 22.52272 ? 131  LEU A C   1 
ATOM   1044 O  O   . LEU A 1 131 ? -35.93016 23.27639 14.63790  1.000 18.47508 ? 131  LEU A O   1 
ATOM   1045 C  CB  . LEU A 1 131 ? -36.20241 24.10830 17.89334  1.000 17.70471 ? 131  LEU A CB  1 
ATOM   1046 C  CG  . LEU A 1 131 ? -37.09892 25.18098 17.28568  1.000 22.75450 ? 131  LEU A CG  1 
ATOM   1047 C  CD1 . LEU A 1 131 ? -38.40983 24.55613 16.79360  1.000 21.77075 ? 131  LEU A CD1 1 
ATOM   1048 C  CD2 . LEU A 1 131 ? -37.36139 26.30106 18.28968  1.000 28.00091 ? 131  LEU A CD2 1 
ATOM   1049 N  N   . LEU A 1 132 ? -34.01165 23.64786 15.75050  1.000 18.03394 ? 132  LEU A N   1 
ATOM   1050 C  CA  . LEU A 1 132 ? -33.29193 23.99312 14.52658  1.000 17.86071 ? 132  LEU A CA  1 
ATOM   1051 C  C   . LEU A 1 132 ? -33.32197 22.84267 13.53292  1.000 17.35627 ? 132  LEU A C   1 
ATOM   1052 O  O   . LEU A 1 132 ? -33.60000 23.04425 12.34488  1.000 17.49531 ? 132  LEU A O   1 
ATOM   1053 C  CB  . LEU A 1 132 ? -31.85022 24.38271 14.85000  1.000 18.03523 ? 132  LEU A CB  1 
ATOM   1054 C  CG  . LEU A 1 132 ? -31.01486 24.84860 13.64727  1.000 16.03260 ? 132  LEU A CG  1 
ATOM   1055 C  CD1 . LEU A 1 132 ? -31.68198 26.00273 12.91414  1.000 11.19416 ? 132  LEU A CD1 1 
ATOM   1056 C  CD2 . LEU A 1 132 ? -29.61376 25.23792 14.10717  1.000 16.27299 ? 132  LEU A CD2 1 
ATOM   1057 N  N   . LEU A 1 133 ? -33.05210 21.61968 14.00587  1.000 13.94023 ? 133  LEU A N   1 
ATOM   1058 C  CA  . LEU A 1 133 ? -33.03191 20.47476 13.10546  1.000 14.81143 ? 133  LEU A CA  1 
ATOM   1059 C  C   . LEU A 1 133 ? -34.40704 20.21659 12.51470  1.000 19.68453 ? 133  LEU A C   1 
ATOM   1060 O  O   . LEU A 1 133 ? -34.51420 19.79386 11.35838  1.000 18.36816 ? 133  LEU A O   1 
ATOM   1061 C  CB  . LEU A 1 133 ? -32.50703 19.23480 13.83283  1.000 16.64073 ? 133  LEU A CB  1 
ATOM   1062 C  CG  . LEU A 1 133 ? -31.03254 19.38255 14.25056  1.000 19.98109 ? 133  LEU A CG  1 
ATOM   1063 C  CD1 . LEU A 1 133 ? -30.52517 18.16757 15.02736  1.000 15.99298 ? 133  LEU A CD1 1 
ATOM   1064 C  CD2 . LEU A 1 133 ? -30.13085 19.67127 13.01921  1.000 17.85925 ? 133  LEU A CD2 1 
ATOM   1065 N  N   . LYS A 1 134 ? -35.46665 20.48074 13.28316  1.000 16.84147 ? 134  LYS A N   1 
ATOM   1066 C  CA  . LYS A 1 134 ? -36.81425 20.37472 12.74392  1.000 17.38992 ? 134  LYS A CA  1 
ATOM   1067 C  C   . LYS A 1 134 ? -37.05267 21.42526 11.66429  1.000 15.35857 ? 134  LYS A C   1 
ATOM   1068 O  O   . LYS A 1 134 ? -37.59126 21.12158 10.59398  1.000 16.30446 ? 134  LYS A O   1 
ATOM   1069 C  CB  . LYS A 1 134 ? -37.83784 20.50688 13.87261  1.000 17.72591 ? 134  LYS A CB  1 
ATOM   1070 C  CG  . LYS A 1 134 ? -39.26252 20.24750 13.42899  1.000 21.71459 ? 134  LYS A CG  1 
ATOM   1071 C  CD  . LYS A 1 134 ? -39.42076 18.84496 12.86167  1.000 29.10814 ? 134  LYS A CD  1 
ATOM   1072 C  CE  . LYS A 1 134 ? -40.20677 18.83687 11.54906  1.000 37.34270 ? 134  LYS A CE  1 
ATOM   1073 N  NZ  . LYS A 1 134 ? -39.37753 18.80465 10.31677  1.000 23.46130 ? 134  LYS A NZ  1 
ATOM   1074 N  N   . ARG A 1 135 ? -36.65215 22.66894 11.92440  1.000 16.04262 ? 135  ARG A N   1 
ATOM   1075 C  CA  . ARG A 1 135 ? -36.78624 23.70632 10.90779  1.000 15.42653 ? 135  ARG A CA  1 
ATOM   1076 C  C   . ARG A 1 135 ? -35.99123 23.35934 9.65504   1.000 14.39508 ? 135  ARG A C   1 
ATOM   1077 O  O   . ARG A 1 135 ? -36.47894 23.53471 8.53169   1.000 15.21280 ? 135  ARG A O   1 
ATOM   1078 C  CB  . ARG A 1 135 ? -36.33124 25.04438 11.47598  1.000 15.15937 ? 135  ARG A CB  1 
ATOM   1079 C  CG  . ARG A 1 135 ? -37.26129 25.59274 12.53734  1.000 16.17798 ? 135  ARG A CG  1 
ATOM   1080 C  CD  . ARG A 1 135 ? -36.61241 26.71351 13.31568  1.000 15.85693 ? 135  ARG A CD  1 
ATOM   1081 N  NE  . ARG A 1 135 ? -37.57908 27.34258 14.20971  1.000 19.02831 ? 135  ARG A NE  1 
ATOM   1082 C  CZ  . ARG A 1 135 ? -37.28730 28.28677 15.09974  1.000 21.12863 ? 135  ARG A CZ  1 
ATOM   1083 N  NH1 . ARG A 1 135 ? -36.04127 28.72515 15.22680  1.000 18.84284 ? 135  ARG A NH1 1 
ATOM   1084 N  NH2 . ARG A 1 135 ? -38.24968 28.79030 15.86450  1.000 18.96918 ? 135  ARG A NH2 1 
ATOM   1085 N  N   . LEU A 1 136 ? -34.76623 22.86484 9.83812   1.000 12.20630 ? 136  LEU A N   1 
ATOM   1086 C  CA  . LEU A 1 136 ? -33.93381 22.43962 8.72225   1.000 13.71510 ? 136  LEU A CA  1 
ATOM   1087 C  C   . LEU A 1 136 ? -34.64157 21.38904 7.88548   1.000 15.34590 ? 136  LEU A C   1 
ATOM   1088 O  O   . LEU A 1 136 ? -34.67708 21.47514 6.64809   1.000 13.06886 ? 136  LEU A O   1 
ATOM   1089 C  CB  . LEU A 1 136 ? -32.61077 21.88198 9.24903   1.000 13.35549 ? 136  LEU A CB  1 
ATOM   1090 C  CG  . LEU A 1 136 ? -31.69950 21.23991 8.19562   1.000 13.82556 ? 136  LEU A CG  1 
ATOM   1091 C  CD1 . LEU A 1 136 ? -31.42419 22.23563 7.08519   1.000 10.34504 ? 136  LEU A CD1 1 
ATOM   1092 C  CD2 . LEU A 1 136 ? -30.38940 20.73467 8.83261   1.000 12.29362 ? 136  LEU A CD2 1 
ATOM   1093 N  N   . GLU A 1 137 ? -35.19367 20.37217 8.54954   1.000 11.75099 ? 137  GLU A N   1 
ATOM   1094 C  CA  . GLU A 1 137 ? -35.85553 19.29115 7.83189   1.000 15.61381 ? 137  GLU A CA  1 
ATOM   1095 C  C   . GLU A 1 137 ? -37.05362 19.79968 7.04144   1.000 11.84968 ? 137  GLU A C   1 
ATOM   1096 O  O   . GLU A 1 137 ? -37.27258 19.38016 5.90066   1.000 12.11967 ? 137  GLU A O   1 
ATOM   1097 C  CB  . GLU A 1 137 ? -36.29278 18.19570 8.80758   1.000 17.37767 ? 137  GLU A CB  1 
ATOM   1098 C  CG  . GLU A 1 137 ? -36.99095 17.05254 8.10847   1.000 24.61288 ? 137  GLU A CG  1 
ATOM   1099 C  CD  . GLU A 1 137 ? -37.07971 15.79344 8.94507   1.000 34.24877 ? 137  GLU A CD  1 
ATOM   1100 O  OE1 . GLU A 1 137 ? -37.92076 14.93432 8.60544   1.000 35.54116 ? 137  GLU A OE1 1 
ATOM   1101 O  OE2 . GLU A 1 137 ? -36.31425 15.65778 9.92815   1.000 41.12758 ? 137  GLU A OE2 1 
ATOM   1102 N  N   . THR A 1 138 ? -37.84623 20.69834 7.63592   1.000 11.08768 ? 138  THR A N   1 
ATOM   1103 C  CA  . THR A 1 138 ? -39.02833 21.20571 6.94484   1.000 13.01612 ? 138  THR A CA  1 
ATOM   1104 C  C   . THR A 1 138 ? -38.64424 22.05073 5.73581   1.000 13.21475 ? 138  THR A C   1 
ATOM   1105 O  O   . THR A 1 138 ? -39.30555 21.99135 4.68960   1.000 11.69745 ? 138  THR A O   1 
ATOM   1106 C  CB  . THR A 1 138 ? -39.88800 22.01959 7.90500   1.000 12.12987 ? 138  THR A CB  1 
ATOM   1107 O  OG1 . THR A 1 138 ? -40.32097 21.18188 8.98164   1.000 16.70046 ? 138  THR A OG1 1 
ATOM   1108 C  CG2 . THR A 1 138 ? -41.09473 22.58053 7.17820   1.000 10.24501 ? 138  THR A CG2 1 
ATOM   1109 N  N   . HIS A 1 139 ? -37.59159 22.86092 5.87202   1.000 12.10521 ? 139  HIS A N   1 
ATOM   1110 C  CA  . HIS A 1 139 ? -37.09784 23.65152 4.74487   1.000 10.23516 ? 139  HIS A CA  1 
ATOM   1111 C  C   . HIS A 1 139 ? -36.72209 22.74450 3.57948   1.000 10.00158 ? 139  HIS A C   1 
ATOM   1112 O  O   . HIS A 1 139 ? -37.21226 22.92013 2.46091   1.000 9.96533  ? 139  HIS A O   1 
ATOM   1113 C  CB  . HIS A 1 139 ? -35.90212 24.48343 5.20609   1.000 9.75943  ? 139  HIS A CB  1 
ATOM   1114 C  CG  . HIS A 1 139 ? -35.25803 25.30959 4.13058   1.000 10.42695 ? 139  HIS A CG  1 
ATOM   1115 N  ND1 . HIS A 1 139 ? -35.73301 26.54772 3.75464   1.000 9.72025  ? 139  HIS A ND1 1 
ATOM   1116 C  CD2 . HIS A 1 139 ? -34.13118 25.10283 3.40434   1.000 11.17470 ? 139  HIS A CD2 1 
ATOM   1117 C  CE1 . HIS A 1 139 ? -34.94181 27.05738 2.82414   1.000 11.59890 ? 139  HIS A CE1 1 
ATOM   1118 N  NE2 . HIS A 1 139 ? -33.95700 26.20305 2.59987   1.000 10.46482 ? 139  HIS A NE2 1 
ATOM   1119 N  N   . ILE A 1 140 ? -35.89312 21.73376 3.85124   1.000 11.49391 ? 140  ILE A N   1 
ATOM   1120 C  CA  . ILE A 1 140 ? -35.43283 20.79636 2.82721   1.000 9.96487  ? 140  ILE A CA  1 
ATOM   1121 C  C   . ILE A 1 140 ? -36.60183 19.99796 2.26822   1.000 12.64043 ? 140  ILE A C   1 
ATOM   1122 O  O   . ILE A 1 140 ? -36.71690 19.79616 1.04941   1.000 11.18953 ? 140  ILE A O   1 
ATOM   1123 C  CB  . ILE A 1 140 ? -34.34252 19.87155 3.41084   1.000 10.63014 ? 140  ILE A CB  1 
ATOM   1124 C  CG1 . ILE A 1 140 ? -33.07773 20.67347 3.72781   1.000 10.58644 ? 140  ILE A CG1 1 
ATOM   1125 C  CG2 . ILE A 1 140 ? -34.01257 18.69335 2.46583   1.000 6.98078  ? 140  ILE A CG2 1 
ATOM   1126 C  CD1 . ILE A 1 140 ? -31.96816 19.84066 4.33011   1.000 8.93871  ? 140  ILE A CD1 1 
ATOM   1127 N  N   . LYS A 1 141 ? -37.46864 19.50466 3.15989   1.000 14.08544 ? 141  LYS A N   1 
ATOM   1128 C  CA  . LYS A 1 141 ? -38.61495 18.70264 2.73640   1.000 11.52707 ? 141  LYS A CA  1 
ATOM   1129 C  C   . LYS A 1 141 ? -39.46535 19.45269 1.72709   1.000 10.09910 ? 141  LYS A C   1 
ATOM   1130 O  O   . LYS A 1 141 ? -39.80547 18.91742 0.67032   1.000 12.82455 ? 141  LYS A O   1 
ATOM   1131 C  CB  . LYS A 1 141 ? -39.46289 18.31907 3.95139   1.000 12.49852 ? 141  LYS A CB  1 
ATOM   1132 C  CG  . LYS A 1 141 ? -40.80515 17.63303 3.63277   1.000 11.45202 ? 141  LYS A CG  1 
ATOM   1133 C  CD  . LYS A 1 141 ? -41.59688 17.44699 4.94318   1.000 14.61915 ? 141  LYS A CD  1 
ATOM   1134 C  CE  . LYS A 1 141 ? -42.95378 16.75619 4.73335   1.000 14.35154 ? 141  LYS A CE  1 
ATOM   1135 N  NZ  . LYS A 1 141 ? -43.96186 17.61623 4.01526   1.000 10.80832 ? 141  LYS A NZ  1 
ATOM   1136 N  N   . THR A 1 142 ? -39.82546 20.69354 2.04533   1.000 8.61052  ? 142  THR A N   1 
ATOM   1137 C  CA  . THR A 1 142 ? -40.70215 21.46355 1.16750   1.000 10.57074 ? 142  THR A CA  1 
ATOM   1138 C  C   . THR A 1 142 ? -40.06235 21.67748 -0.19822  1.000 10.89077 ? 142  THR A C   1 
ATOM   1139 O  O   . THR A 1 142 ? -40.71573 21.50427 -1.23330  1.000 9.02890  ? 142  THR A O   1 
ATOM   1140 C  CB  . THR A 1 142 ? -41.03381 22.80815 1.82223   1.000 10.27151 ? 142  THR A CB  1 
ATOM   1141 O  OG1 . THR A 1 142 ? -41.53538 22.58744 3.15015   1.000 12.27198 ? 142  THR A OG1 1 
ATOM   1142 C  CG2 . THR A 1 142 ? -42.06338 23.57293 1.01841   1.000 10.92432 ? 142  THR A CG2 1 
ATOM   1143 N  N   . ILE A 1 143 ? -38.78141 22.05058 -0.21648  1.000 9.06709  ? 143  ILE A N   1 
ATOM   1144 C  CA  . ILE A 1 143 ? -38.08352 22.29893 -1.47577  1.000 11.87524 ? 143  ILE A CA  1 
ATOM   1145 C  C   . ILE A 1 143 ? -37.98434 21.01934 -2.29630  1.000 9.62391  ? 143  ILE A C   1 
ATOM   1146 O  O   . ILE A 1 143 ? -38.28440 20.99804 -3.49437  1.000 10.93122 ? 143  ILE A O   1 
ATOM   1147 C  CB  . ILE A 1 143 ? -36.69132 22.89154 -1.19972  1.000 10.30268 ? 143  ILE A CB  1 
ATOM   1148 C  CG1 . ILE A 1 143 ? -36.82700 24.28527 -0.57093  1.000 9.34099  ? 143  ILE A CG1 1 
ATOM   1149 C  CG2 . ILE A 1 143 ? -35.86141 22.91560 -2.49050  1.000 7.92990  ? 143  ILE A CG2 1 
ATOM   1150 C  CD1 . ILE A 1 143 ? -35.52875 24.78329 0.10393   1.000 11.40496 ? 143  ILE A CD1 1 
ATOM   1151 N  N   . VAL A 1 144 ? -37.55545 19.93007 -1.66310  1.000 9.58346  ? 144  VAL A N   1 
ATOM   1152 C  CA  . VAL A 1 144 ? -37.26651 18.72139 -2.41971  1.000 8.70855  ? 144  VAL A CA  1 
ATOM   1153 C  C   . VAL A 1 144 ? -38.55924 18.05866 -2.88546  1.000 13.19985 ? 144  VAL A C   1 
ATOM   1154 O  O   . VAL A 1 144 ? -38.62718 17.51078 -3.99391  1.000 8.43788  ? 144  VAL A O   1 
ATOM   1155 C  CB  . VAL A 1 144 ? -36.38968 17.78018 -1.57135  1.000 14.88983 ? 144  VAL A CB  1 
ATOM   1156 C  CG1 . VAL A 1 144 ? -36.27629 16.46646 -2.22625  1.000 13.76221 ? 144  VAL A CG1 1 
ATOM   1157 C  CG2 . VAL A 1 144 ? -34.98000 18.37661 -1.40130  1.000 10.83125 ? 144  VAL A CG2 1 
ATOM   1158 N  N   . GLU A 1 145 ? -39.61669 18.12282 -2.06633  1.000 9.02437  ? 145  GLU A N   1 
ATOM   1159 C  CA  . GLU A 1 145 ? -40.91179 17.60432 -2.51209  1.000 10.29078 ? 145  GLU A CA  1 
ATOM   1160 C  C   . GLU A 1 145 ? -41.38755 18.30852 -3.77644  1.000 8.54986  ? 145  GLU A C   1 
ATOM   1161 O  O   . GLU A 1 145 ? -42.01905 17.68097 -4.62798  1.000 10.23271 ? 145  GLU A O   1 
ATOM   1162 C  CB  . GLU A 1 145 ? -41.95840 17.73134 -1.38952  1.000 7.73641  ? 145  GLU A CB  1 
ATOM   1163 C  CG  . GLU A 1 145 ? -41.72051 16.70547 -0.27628  1.000 11.03167 ? 145  GLU A CG  1 
ATOM   1164 C  CD  . GLU A 1 145 ? -42.71693 16.77925 0.86769   1.000 10.91768 ? 145  GLU A CD  1 
ATOM   1165 O  OE1 . GLU A 1 145 ? -43.20911 17.87937 1.19853   1.000 11.14687 ? 145  GLU A OE1 1 
ATOM   1166 O  OE2 . GLU A 1 145 ? -43.00077 15.71562 1.44273   1.000 13.34738 ? 145  GLU A OE2 1 
ATOM   1167 N  N   . ARG A 1 146 ? -41.06373 19.59153 -3.93516  1.000 8.77176  ? 146  ARG A N   1 
ATOM   1168 C  CA  . ARG A 1 146 ? -41.49174 20.32441 -5.12437  1.000 9.65369  ? 146  ARG A CA  1 
ATOM   1169 C  C   . ARG A 1 146 ? -40.64004 19.99777 -6.35355  1.000 10.96756 ? 146  ARG A C   1 
ATOM   1170 O  O   . ARG A 1 146 ? -41.17463 19.90861 -7.46320  1.000 11.19973 ? 146  ARG A O   1 
ATOM   1171 C  CB  . ARG A 1 146 ? -41.45347 21.82998 -4.85914  1.000 11.11006 ? 146  ARG A CB  1 
ATOM   1172 C  CG  . ARG A 1 146 ? -41.97755 22.68920 -6.02328  1.000 7.95986  ? 146  ARG A CG  1 
ATOM   1173 C  CD  . ARG A 1 146 ? -41.97343 24.16097 -5.62922  1.000 12.94943 ? 146  ARG A CD  1 
ATOM   1174 N  NE  . ARG A 1 146 ? -42.56313 25.06139 -6.62602  1.000 10.78023 ? 146  ARG A NE  1 
ATOM   1175 C  CZ  . ARG A 1 146 ? -43.86824 25.30205 -6.74653  1.000 14.75910 ? 146  ARG A CZ  1 
ATOM   1176 N  NH1 . ARG A 1 146 ? -44.73616 24.69433 -5.94163  1.000 9.68966  ? 146  ARG A NH1 1 
ATOM   1177 N  NH2 . ARG A 1 146 ? -44.30810 26.14622 -7.67461  1.000 9.49347  ? 146  ARG A NH2 1 
ATOM   1178 N  N   . TYR A 1 147 ? -39.32073 19.82321 -6.18934  1.000 9.99174  ? 147  TYR A N   1 
ATOM   1179 C  CA  . TYR A 1 147 ? -38.39986 19.79435 -7.32398  1.000 10.65148 ? 147  TYR A CA  1 
ATOM   1180 C  C   . TYR A 1 147 ? -37.75925 18.43915 -7.59745  1.000 10.84997 ? 147  TYR A C   1 
ATOM   1181 O  O   . TYR A 1 147 ? -36.94453 18.34834 -8.51542  1.000 9.34195  ? 147  TYR A O   1 
ATOM   1182 C  CB  . TYR A 1 147 ? -37.27973 20.82506 -7.11551  1.000 9.73296  ? 147  TYR A CB  1 
ATOM   1183 C  CG  . TYR A 1 147 ? -37.74895 22.25421 -7.17854  1.000 10.57827 ? 147  TYR A CG  1 
ATOM   1184 C  CD1 . TYR A 1 147 ? -38.54011 22.70465 -8.23422  1.000 11.22044 ? 147  TYR A CD1 1 
ATOM   1185 C  CD2 . TYR A 1 147 ? -37.41756 23.14876 -6.17967  1.000 11.41809 ? 147  TYR A CD2 1 
ATOM   1186 C  CE1 . TYR A 1 147 ? -38.95739 24.01513 -8.29403  1.000 10.85915 ? 147  TYR A CE1 1 
ATOM   1187 C  CE2 . TYR A 1 147 ? -37.84177 24.46551 -6.22594  1.000 12.80768 ? 147  TYR A CE2 1 
ATOM   1188 C  CZ  . TYR A 1 147 ? -38.60352 24.89057 -7.27969  1.000 10.17303 ? 147  TYR A CZ  1 
ATOM   1189 O  OH  . TYR A 1 147 ? -39.01598 26.20342 -7.31854  1.000 12.23416 ? 147  TYR A OH  1 
ATOM   1190 N  N   . LYS A 1 148 ? -38.11336 17.38624 -6.85383  1.000 10.10855 ? 148  LYS A N   1 
ATOM   1191 C  CA  . LYS A 1 148 ? -37.37176 16.12460 -6.93271  1.000 14.28865 ? 148  LYS A CA  1 
ATOM   1192 C  C   . LYS A 1 148 ? -37.42114 15.48725 -8.31911  1.000 13.79937 ? 148  LYS A C   1 
ATOM   1193 O  O   . LYS A 1 148 ? -36.49321 14.75736 -8.69190  1.000 12.85066 ? 148  LYS A O   1 
ATOM   1194 C  CB  . LYS A 1 148 ? -37.90602 15.13036 -5.89933  1.000 14.13827 ? 148  LYS A CB  1 
ATOM   1195 C  CG  . LYS A 1 148 ? -39.38590 14.79376 -6.05202  1.000 13.40575 ? 148  LYS A CG  1 
ATOM   1196 C  CD  . LYS A 1 148 ? -39.79628 13.77022 -4.99431  1.000 19.50294 ? 148  LYS A CD  1 
ATOM   1197 C  CE  . LYS A 1 148 ? -41.07762 13.03299 -5.36185  1.000 27.61409 ? 148  LYS A CE  1 
ATOM   1198 N  NZ  . LYS A 1 148 ? -42.16737 13.95209 -5.77767  1.000 31.20056 ? 148  LYS A NZ  1 
ATOM   1199 N  N   . ASP A 1 149 ? -38.49105 15.72142 -9.08374  1.000 12.62868 ? 149  ASP A N   1 
ATOM   1200 C  CA  . ASP A 1 149 ? -38.60958 15.15091 -10.42028 1.000 13.90849 ? 149  ASP A CA  1 
ATOM   1201 C  C   . ASP A 1 149 ? -37.95020 16.00522 -11.49841 1.000 16.59436 ? 149  ASP A C   1 
ATOM   1202 O  O   . ASP A 1 149 ? -37.89588 15.57510 -12.65005 1.000 16.27697 ? 149  ASP A O   1 
ATOM   1203 C  CB  . ASP A 1 149 ? -40.08592 14.94167 -10.78385 1.000 17.73191 ? 149  ASP A CB  1 
ATOM   1204 C  CG  . ASP A 1 149 ? -40.77532 13.91359 -9.88459  1.000 16.64937 ? 149  ASP A CG  1 
ATOM   1205 O  OD1 . ASP A 1 149 ? -40.11944 12.93701 -9.48626  1.000 21.65777 ? 149  ASP A OD1 1 
ATOM   1206 O  OD2 . ASP A 1 149 ? -41.97088 14.08337 -9.59016  1.000 29.09931 ? 149  ASP A OD2 1 
ATOM   1207 N  N   . ASP A 1 150 ? -37.46823 17.20158 -11.16299 1.000 10.63947 ? 150  ASP A N   1 
ATOM   1208 C  CA  . ASP A 1 150 ? -36.90948 18.12796 -12.14793 1.000 13.87605 ? 150  ASP A CA  1 
ATOM   1209 C  C   . ASP A 1 150 ? -35.42561 18.39599 -11.96607 1.000 13.16137 ? 150  ASP A C   1 
ATOM   1210 O  O   . ASP A 1 150 ? -34.74016 18.67132 -12.95026 1.000 9.59922  ? 150  ASP A O   1 
ATOM   1211 C  CB  . ASP A 1 150 ? -37.63563 19.47720 -12.08974 1.000 12.36050 ? 150  ASP A CB  1 
ATOM   1212 C  CG  . ASP A 1 150 ? -39.13068 19.34756 -12.33050 1.000 19.29988 ? 150  ASP A CG  1 
ATOM   1213 O  OD1 . ASP A 1 150 ? -39.50855 18.61387 -13.26324 1.000 19.57133 ? 150  ASP A OD1 1 
ATOM   1214 O  OD2 . ASP A 1 150 ? -39.90944 19.97718 -11.58295 1.000 24.59983 ? 150  ASP A OD2 1 
ATOM   1215 N  N   . ILE A 1 151 ? -34.92460 18.35780 -10.73363 1.000 8.34019  ? 151  ILE A N   1 
ATOM   1216 C  CA  . ILE A 1 151 ? -33.56114 18.77622 -10.42056 1.000 10.24553 ? 151  ILE A CA  1 
ATOM   1217 C  C   . ILE A 1 151 ? -32.77066 17.54466 -10.01314 1.000 12.25527 ? 151  ILE A C   1 
ATOM   1218 O  O   . ILE A 1 151 ? -33.06786 16.91511 -8.98760  1.000 9.68927  ? 151  ILE A O   1 
ATOM   1219 C  CB  . ILE A 1 151 ? -33.53562 19.84069 -9.31345  1.000 13.33122 ? 151  ILE A CB  1 
ATOM   1220 C  CG1 . ILE A 1 151 ? -34.34193 21.07382 -9.74894  1.000 10.40044 ? 151  ILE A CG1 1 
ATOM   1221 C  CG2 . ILE A 1 151 ? -32.08105 20.17655 -8.94522  1.000 9.24358  ? 151  ILE A CG2 1 
ATOM   1222 C  CD1 . ILE A 1 151 ? -34.29372 22.25197 -8.76222  1.000 9.25367  ? 151  ILE A CD1 1 
ATOM   1223 N  N   . LYS A 1 152 ? -31.76979 17.19263 -10.81930 1.000 9.86257  ? 152  LYS A N   1 
ATOM   1224 C  CA  . LYS A 1 152 ? -31.00841 15.97775 -10.55363 1.000 13.08487 ? 152  LYS A CA  1 
ATOM   1225 C  C   . LYS A 1 152 ? -29.90221 16.18755 -9.51945  1.000 13.59765 ? 152  LYS A C   1 
ATOM   1226 O  O   . LYS A 1 152 ? -29.60165 15.26187 -8.75567  1.000 12.03990 ? 152  LYS A O   1 
ATOM   1227 C  CB  . LYS A 1 152 ? -30.41130 15.44277 -11.86136 1.000 16.26794 ? 152  LYS A CB  1 
ATOM   1228 C  CG  . LYS A 1 152 ? -29.50120 14.23219 -11.70381 1.000 18.42191 ? 152  LYS A CG  1 
ATOM   1229 C  CD  . LYS A 1 152 ? -30.26657 12.92540 -11.88961 1.000 34.22568 ? 152  LYS A CD  1 
ATOM   1230 C  CE  . LYS A 1 152 ? -29.33555 11.70356 -11.92517 1.000 38.47373 ? 152  LYS A CE  1 
ATOM   1231 N  NZ  . LYS A 1 152 ? -30.02383 10.43126 -11.47486 1.000 37.07030 ? 152  LYS A NZ  1 
ATOM   1232 N  N   . TYR A 1 153 ? -29.28522 17.37311 -9.47501  1.000 10.03904 ? 153  TYR A N   1 
ATOM   1233 C  CA  . TYR A 1 153 ? -28.07098 17.60068 -8.69703  1.000 9.60751  ? 153  TYR A CA  1 
ATOM   1234 C  C   . TYR A 1 153 ? -28.32937 18.64073 -7.61682  1.000 9.24209  ? 153  TYR A C   1 
ATOM   1235 O  O   . TYR A 1 153 ? -28.87415 19.71215 -7.90697  1.000 7.03198  ? 153  TYR A O   1 
ATOM   1236 C  CB  . TYR A 1 153 ? -26.91691 18.05515 -9.60533  1.000 8.72686  ? 153  TYR A CB  1 
ATOM   1237 C  CG  . TYR A 1 153 ? -26.62319 17.05698 -10.70293 1.000 10.24317 ? 153  TYR A CG  1 
ATOM   1238 C  CD1 . TYR A 1 153 ? -25.91220 15.89917 -10.43843 1.000 10.81171 ? 153  TYR A CD1 1 
ATOM   1239 C  CD2 . TYR A 1 153 ? -27.07684 17.26195 -11.99266 1.000 13.97600 ? 153  TYR A CD2 1 
ATOM   1240 C  CE1 . TYR A 1 153 ? -25.64556 14.97077 -11.44354 1.000 12.55909 ? 153  TYR A CE1 1 
ATOM   1241 C  CE2 . TYR A 1 153 ? -26.82277 16.34381 -13.00418 1.000 13.89328 ? 153  TYR A CE2 1 
ATOM   1242 C  CZ  . TYR A 1 153 ? -26.10388 15.19952 -12.72245 1.000 16.26860 ? 153  TYR A CZ  1 
ATOM   1243 O  OH  . TYR A 1 153 ? -25.85136 14.28103 -13.72640 1.000 16.79570 ? 153  TYR A OH  1 
ATOM   1244 N  N   . TRP A 1 154 ? -27.91332 18.33194 -6.38237  1.000 7.14941  ? 154  TRP A N   1 
ATOM   1245 C  CA  . TRP A 1 154 ? -28.23478 19.14264 -5.21227  1.000 8.60621  ? 154  TRP A CA  1 
ATOM   1246 C  C   . TRP A 1 154 ? -26.97709 19.46851 -4.42530  1.000 10.17077 ? 154  TRP A C   1 
ATOM   1247 O  O   . TRP A 1 154 ? -26.28698 18.55579 -3.95194  1.000 9.17146  ? 154  TRP A O   1 
ATOM   1248 C  CB  . TRP A 1 154 ? -29.23356 18.41709 -4.30342  1.000 8.52036  ? 154  TRP A CB  1 
ATOM   1249 C  CG  . TRP A 1 154 ? -30.55142 18.25597 -4.94847  1.000 7.90369  ? 154  TRP A CG  1 
ATOM   1250 C  CD1 . TRP A 1 154 ? -30.88648 17.35667 -5.92763  1.000 9.35476  ? 154  TRP A CD1 1 
ATOM   1251 C  CD2 . TRP A 1 154 ? -31.71710 19.04066 -4.70135  1.000 6.44936  ? 154  TRP A CD2 1 
ATOM   1252 N  NE1 . TRP A 1 154 ? -32.20374 17.52894 -6.29403  1.000 9.24279  ? 154  TRP A NE1 1 
ATOM   1253 C  CE2 . TRP A 1 154 ? -32.73643 18.55603 -5.55327  1.000 9.08911  ? 154  TRP A CE2 1 
ATOM   1254 C  CE3 . TRP A 1 154 ? -32.00166 20.11061 -3.84275  1.000 8.19303  ? 154  TRP A CE3 1 
ATOM   1255 C  CZ2 . TRP A 1 154 ? -34.01326 19.10369 -5.57259  1.000 8.47495  ? 154  TRP A CZ2 1 
ATOM   1256 C  CZ3 . TRP A 1 154 ? -33.27576 20.65234 -3.86164  1.000 9.39005  ? 154  TRP A CZ3 1 
ATOM   1257 C  CH2 . TRP A 1 154 ? -34.26607 20.14701 -4.72185  1.000 8.92304  ? 154  TRP A CH2 1 
ATOM   1258 N  N   . ASP A 1 155 ? -26.69490 20.76670 -4.26105  1.000 9.19431  ? 155  ASP A N   1 
ATOM   1259 C  CA  . ASP A 1 155 ? -25.75070 21.21376 -3.23611  1.000 7.84533  ? 155  ASP A CA  1 
ATOM   1260 C  C   . ASP A 1 155 ? -26.50072 21.21247 -1.91035  1.000 8.22384  ? 155  ASP A C   1 
ATOM   1261 O  O   . ASP A 1 155 ? -27.20291 22.16949 -1.57465  1.000 9.53163  ? 155  ASP A O   1 
ATOM   1262 C  CB  . ASP A 1 155 ? -25.18482 22.59390 -3.55559  1.000 7.14294  ? 155  ASP A CB  1 
ATOM   1263 C  CG  . ASP A 1 155 ? -24.19033 22.56742 -4.69668  1.000 10.66044 ? 155  ASP A CG  1 
ATOM   1264 O  OD1 . ASP A 1 155 ? -23.49849 21.52868 -4.88201  1.000 11.34208 ? 155  ASP A OD1 1 
ATOM   1265 O  OD2 . ASP A 1 155 ? -24.11023 23.58810 -5.41736  1.000 9.48317  ? 155  ASP A OD2 1 
ATOM   1266 N  N   . VAL A 1 156 ? -26.35800 20.12346 -1.15499  1.000 8.33906  ? 156  VAL A N   1 
ATOM   1267 C  CA  . VAL A 1 156 ? -27.10356 19.97121 0.09088   1.000 9.86738  ? 156  VAL A CA  1 
ATOM   1268 C  C   . VAL A 1 156 ? -26.56686 20.92147 1.15542   1.000 10.08625 ? 156  VAL A C   1 
ATOM   1269 O  O   . VAL A 1 156 ? -27.32527 21.66672 1.78925   1.000 11.41187 ? 156  VAL A O   1 
ATOM   1270 C  CB  . VAL A 1 156 ? -27.05546 18.50951 0.56257   1.000 11.21809 ? 156  VAL A CB  1 
ATOM   1271 C  CG1 . VAL A 1 156 ? -27.73755 18.37000 1.92612   1.000 12.67628 ? 156  VAL A CG1 1 
ATOM   1272 C  CG2 . VAL A 1 156 ? -27.71523 17.61314 -0.46323  1.000 8.52016  ? 156  VAL A CG2 1 
ATOM   1273 N  N   . VAL A 1 157 ? -25.25338 20.90772 1.37425   1.000 11.55358 ? 157  VAL A N   1 
ATOM   1274 C  CA  . VAL A 1 157 ? -24.62606 21.86397 2.27383   1.000 9.22405  ? 157  VAL A CA  1 
ATOM   1275 C  C   . VAL A 1 157 ? -23.46262 22.52274 1.54358   1.000 9.72859  ? 157  VAL A C   1 
ATOM   1276 O  O   . VAL A 1 157 ? -22.77292 21.89703 0.73245   1.000 11.28984 ? 157  VAL A O   1 
ATOM   1277 C  CB  . VAL A 1 157 ? -24.15587 21.21270 3.59913   1.000 9.31944  ? 157  VAL A CB  1 
ATOM   1278 C  CG1 . VAL A 1 157 ? -25.30092 20.45130 4.25304   1.000 10.73468 ? 157  VAL A CG1 1 
ATOM   1279 C  CG2 . VAL A 1 157 ? -22.92596 20.30566 3.36732   1.000 8.33623  ? 157  VAL A CG2 1 
ATOM   1280 N  N   . THR A 1 158 ? -23.24753 23.79598 1.84699   1.000 8.79698  ? 158  THR A N   1 
ATOM   1281 C  CA  . THR A 1 158 ? -22.21051 24.59845 1.21477   1.000 9.07661  ? 158  THR A CA  1 
ATOM   1282 C  C   . THR A 1 158 ? -21.31288 25.20788 2.28912   1.000 14.00351 ? 158  THR A C   1 
ATOM   1283 O  O   . THR A 1 158 ? -21.80924 25.79426 3.25687   1.000 11.47005 ? 158  THR A O   1 
ATOM   1284 C  CB  . THR A 1 158 ? -22.85678 25.68534 0.34319   1.000 9.53455  ? 158  THR A CB  1 
ATOM   1285 O  OG1 . THR A 1 158 ? -23.58306 25.05337 -0.71827  1.000 8.03785  ? 158  THR A OG1 1 
ATOM   1286 C  CG2 . THR A 1 158 ? -21.80987 26.64528 -0.25934  1.000 9.19604  ? 158  THR A CG2 1 
ATOM   1287 N  N   . GLU A 1 159 ? -19.99948 25.02587 2.13406   1.000 9.36661  ? 159  GLU A N   1 
ATOM   1288 C  CA  . GLU A 1 159 ? -18.97634 25.70526 2.93904   1.000 10.85190 ? 159  GLU A CA  1 
ATOM   1289 C  C   . GLU A 1 159 ? -19.06151 25.35593 4.42899   1.000 12.30473 ? 159  GLU A C   1 
ATOM   1290 O  O   . GLU A 1 159 ? -18.98285 26.22130 5.30150   1.000 12.57778 ? 159  GLU A O   1 
ATOM   1291 C  CB  . GLU A 1 159 ? -19.04646 27.22202 2.71363   1.000 9.44320  ? 159  GLU A CB  1 
ATOM   1292 C  CG  . GLU A 1 159 ? -18.61095 27.62109 1.29113   1.000 9.99754  ? 159  GLU A CG  1 
ATOM   1293 C  CD  . GLU A 1 159 ? -18.87830 29.08713 0.97217   1.000 17.21488 ? 159  GLU A CD  1 
ATOM   1294 O  OE1 . GLU A 1 159 ? -19.10527 29.87486 1.91817   1.000 11.26081 ? 159  GLU A OE1 1 
ATOM   1295 O  OE2 . GLU A 1 159 ? -18.85504 29.44730 -0.22563  1.000 15.61505 ? 159  GLU A OE2 1 
ATOM   1296 N  N   . VAL A 1 160 ? -19.20202 24.06178 4.73138   1.000 9.65309  ? 160  VAL A N   1 
ATOM   1297 C  CA  . VAL A 1 160 ? -19.32331 23.65557 6.13121   1.000 11.33404 ? 160  VAL A CA  1 
ATOM   1298 C  C   . VAL A 1 160 ? -17.97188 23.38203 6.78662   1.000 14.41921 ? 160  VAL A C   1 
ATOM   1299 O  O   . VAL A 1 160 ? -17.92374 23.13937 8.00083   1.000 11.64689 ? 160  VAL A O   1 
ATOM   1300 C  CB  . VAL A 1 160 ? -20.22969 22.41860 6.28560   1.000 12.89710 ? 160  VAL A CB  1 
ATOM   1301 C  CG1 . VAL A 1 160 ? -21.61540 22.72168 5.77091   1.000 7.64723  ? 160  VAL A CG1 1 
ATOM   1302 C  CG2 . VAL A 1 160 ? -19.61518 21.20759 5.58142   1.000 12.05091 ? 160  VAL A CG2 1 
ATOM   1303 N  N   . VAL A 1 161 ? -16.87543 23.43447 6.02773   1.000 10.16546 ? 161  VAL A N   1 
ATOM   1304 C  CA  . VAL A 1 161 ? -15.52631 23.26868 6.55807   1.000 12.17422 ? 161  VAL A CA  1 
ATOM   1305 C  C   . VAL A 1 161 ? -14.82869 24.61990 6.49411   1.000 14.93591 ? 161  VAL A C   1 
ATOM   1306 O  O   . VAL A 1 161 ? -14.86354 25.29480 5.45785   1.000 13.53099 ? 161  VAL A O   1 
ATOM   1307 C  CB  . VAL A 1 161 ? -14.74926 22.18988 5.77916   1.000 13.86730 ? 161  VAL A CB  1 
ATOM   1308 C  CG1 . VAL A 1 161 ? -13.28694 22.11530 6.23875   1.000 13.71092 ? 161  VAL A CG1 1 
ATOM   1309 C  CG2 . VAL A 1 161 ? -15.42606 20.83526 5.94354   1.000 13.72957 ? 161  VAL A CG2 1 
ATOM   1310 N  N   . GLY A 1 162 ? -14.23480 25.03467 7.61186   1.000 13.65104 ? 162  GLY A N   1 
ATOM   1311 C  CA  . GLY A 1 162 ? -13.53520 26.29712 7.63881   1.000 13.22430 ? 162  GLY A CA  1 
ATOM   1312 C  C   . GLY A 1 162 ? -12.20161 26.22345 6.91324   1.000 16.64102 ? 162  GLY A C   1 
ATOM   1313 O  O   . GLY A 1 162 ? -11.63797 25.15654 6.69167   1.000 14.69601 ? 162  GLY A O   1 
ATOM   1314 N  N   . ASP A 1 163 ? -11.69126 27.39579 6.53197   1.000 12.22936 ? 163  ASP A N   1 
ATOM   1315 C  CA  . ASP A 1 163 ? -10.38424 27.45947 5.88571   1.000 13.72377 ? 163  ASP A CA  1 
ATOM   1316 C  C   . ASP A 1 163 ? -9.23915  27.05980 6.82204   1.000 19.18384 ? 163  ASP A C   1 
ATOM   1317 O  O   . ASP A 1 163 ? -8.15074  26.71642 6.33803   1.000 17.31141 ? 163  ASP A O   1 
ATOM   1318 C  CB  . ASP A 1 163 ? -10.17859 28.85993 5.32241   1.000 15.18279 ? 163  ASP A CB  1 
ATOM   1319 C  CG  . ASP A 1 163 ? -11.04842 29.11925 4.10865   1.000 11.66864 ? 163  ASP A CG  1 
ATOM   1320 O  OD1 . ASP A 1 163 ? -11.10636 28.24464 3.21633   1.000 16.05027 ? 163  ASP A OD1 1 
ATOM   1321 O  OD2 . ASP A 1 163 ? -11.68136 30.18302 4.04086   1.000 12.04043 ? 163  ASP A OD2 1 
ATOM   1322 N  N   . ASP A 1 164 ? -9.47012  27.06042 8.14129   1.000 17.76058 ? 164  ASP A N   1 
ATOM   1323 C  CA  . ASP A 1 164 ? -8.52858  26.52900 9.12345   1.000 16.15263 ? 164  ASP A CA  1 
ATOM   1324 C  C   . ASP A 1 164 ? -8.60653  25.00894 9.26115   1.000 21.69671 ? 164  ASP A C   1 
ATOM   1325 O  O   . ASP A 1 164 ? -7.95237  24.44570 10.14299  1.000 19.93454 ? 164  ASP A O   1 
ATOM   1326 C  CB  . ASP A 1 164 ? -8.76178  27.17564 10.49640  1.000 19.30670 ? 164  ASP A CB  1 
ATOM   1327 C  CG  . ASP A 1 164 ? -10.17621 26.91390 11.05030  1.000 21.00593 ? 164  ASP A CG  1 
ATOM   1328 O  OD1 . ASP A 1 164 ? -10.96854 26.18241 10.41653  1.000 20.15170 ? 164  ASP A OD1 1 
ATOM   1329 O  OD2 . ASP A 1 164 ? -10.49780 27.44864 12.12958  1.000 22.48788 ? 164  ASP A OD2 1 
ATOM   1330 N  N   . GLY A 1 165 ? -9.39360  24.33023 8.43016   1.000 16.36169 ? 165  GLY A N   1 
ATOM   1331 C  CA  . GLY A 1 165 ? -9.46771  22.88666 8.50512   1.000 17.10471 ? 165  GLY A CA  1 
ATOM   1332 C  C   . GLY A 1 165 ? -10.34804 22.34665 9.61266   1.000 19.99980 ? 165  GLY A C   1 
ATOM   1333 O  O   . GLY A 1 165 ? -10.43210 21.12180 9.77565   1.000 21.94535 ? 165  GLY A O   1 
ATOM   1334 N  N   . LYS A 1 166 ? -10.99528 23.21073 10.37976  1.000 17.90574 ? 166  LYS A N   1 
ATOM   1335 C  CA  . LYS A 1 166 ? -11.99546 22.80917 11.35587  1.000 22.42704 ? 166  LYS A CA  1 
ATOM   1336 C  C   . LYS A 1 166 ? -13.38064 23.02732 10.75193  1.000 20.21732 ? 166  LYS A C   1 
ATOM   1337 O  O   . LYS A 1 166 ? -13.54281 23.77431 9.78676   1.000 16.17960 ? 166  LYS A O   1 
ATOM   1338 C  CB  . LYS A 1 166 ? -11.85154 23.62088 12.65315  1.000 20.67811 ? 166  LYS A CB  1 
ATOM   1339 C  CG  . LYS A 1 166 ? -10.72963 23.17070 13.61247  1.000 30.28936 ? 166  LYS A CG  1 
ATOM   1340 C  CD  . LYS A 1 166 ? -9.36648  23.06599 12.94971  1.000 34.39354 ? 166  LYS A CD  1 
ATOM   1341 C  CE  . LYS A 1 166 ? -8.24578  22.84407 13.97222  1.000 48.32579 ? 166  LYS A CE  1 
ATOM   1342 N  NZ  . LYS A 1 166 ? -7.98133  24.06316 14.79061  1.000 46.16240 ? 166  LYS A NZ  1 
ATOM   1343 N  N   . LEU A 1 167 ? -14.38635 22.37497 11.32592  1.000 16.69399 ? 167  LEU A N   1 
ATOM   1344 C  CA  . LEU A 1 167 ? -15.74100 22.65303 10.87325  1.000 19.47992 ? 167  LEU A CA  1 
ATOM   1345 C  C   . LEU A 1 167 ? -16.03414 24.13329 11.06719  1.000 19.70144 ? 167  LEU A C   1 
ATOM   1346 O  O   . LEU A 1 167 ? -15.62612 24.73569 12.06490  1.000 16.72499 ? 167  LEU A O   1 
ATOM   1347 C  CB  . LEU A 1 167 ? -16.74519 21.78678 11.62017  1.000 19.78260 ? 167  LEU A CB  1 
ATOM   1348 C  CG  . LEU A 1 167 ? -16.76220 20.36227 11.06481  1.000 19.38418 ? 167  LEU A CG  1 
ATOM   1349 C  CD1 . LEU A 1 167 ? -17.15211 19.36257 12.13978  1.000 26.82537 ? 167  LEU A CD1 1 
ATOM   1350 C  CD2 . LEU A 1 167 ? -17.73958 20.30275 9.91545   1.000 23.03804 ? 167  LEU A CD2 1 
ATOM   1351 N  N   . ARG A 1 168 ? -16.66592 24.74626 10.06701  1.000 12.83016 ? 168  ARG A N   1 
ATOM   1352 C  CA  . ARG A 1 168 ? -16.97537 26.16473 10.17550  1.000 13.94182 ? 168  ARG A CA  1 
ATOM   1353 C  C   . ARG A 1 168 ? -17.94245 26.38884 11.33336  1.000 19.32855 ? 168  ARG A C   1 
ATOM   1354 O  O   . ARG A 1 168 ? -18.98208 25.72771 11.42475  1.000 16.08575 ? 168  ARG A O   1 
ATOM   1355 C  CB  . ARG A 1 168 ? -17.57881 26.68379 8.87148   1.000 14.21612 ? 168  ARG A CB  1 
ATOM   1356 C  CG  . ARG A 1 168 ? -17.96637 28.15197 8.94495   1.000 16.02042 ? 168  ARG A CG  1 
ATOM   1357 C  CD  . ARG A 1 168 ? -18.62151 28.60730 7.64946   1.000 16.78177 ? 168  ARG A CD  1 
ATOM   1358 N  NE  . ARG A 1 168 ? -17.72783 28.51321 6.49620   1.000 12.40076 ? 168  ARG A NE  1 
ATOM   1359 C  CZ  . ARG A 1 168 ? -16.83920 29.45030 6.16344   1.000 15.06172 ? 168  ARG A CZ  1 
ATOM   1360 N  NH1 . ARG A 1 168 ? -16.71983 30.54259 6.91362   1.000 13.71904 ? 168  ARG A NH1 1 
ATOM   1361 N  NH2 . ARG A 1 168 ? -16.07375 29.30217 5.07911   1.000 12.17183 ? 168  ARG A NH2 1 
ATOM   1362 N  N   . ASN A 1 169 ? -17.59349 27.31739 12.22191  1.000 18.48467 ? 169  ASN A N   1 
ATOM   1363 C  CA  . ASN A 1 169 ? -18.34982 27.55393 13.45455  1.000 15.47150 ? 169  ASN A CA  1 
ATOM   1364 C  C   . ASN A 1 169 ? -19.50378 28.52494 13.22263  1.000 20.28496 ? 169  ASN A C   1 
ATOM   1365 O  O   . ASN A 1 169 ? -19.65649 29.54354 13.89535  1.000 18.00349 ? 169  ASN A O   1 
ATOM   1366 C  CB  . ASN A 1 169 ? -17.41047 28.05395 14.54917  1.000 19.77420 ? 169  ASN A CB  1 
ATOM   1367 C  CG  . ASN A 1 169 ? -17.99495 27.89119 15.95414  1.000 21.79441 ? 169  ASN A CG  1 
ATOM   1368 O  OD1 . ASN A 1 169 ? -18.66761 26.90855 16.25709  1.000 23.10398 ? 169  ASN A OD1 1 
ATOM   1369 N  ND2 . ASN A 1 169 ? -17.73413 28.86299 16.81132  1.000 28.72860 ? 169  ASN A ND2 1 
ATOM   1370 N  N   . SER A 1 170 ? -20.33385 28.20120 12.23825  1.000 19.10050 ? 170  SER A N   1 
ATOM   1371 C  CA  . SER A 1 170 ? -21.52303 28.97488 11.95647  1.000 16.08365 ? 170  SER A CA  1 
ATOM   1372 C  C   . SER A 1 170 ? -22.57115 28.71844 13.03622  1.000 15.00891 ? 170  SER A C   1 
ATOM   1373 O  O   . SER A 1 170 ? -22.43667 27.79116 13.83669  1.000 14.71418 ? 170  SER A O   1 
ATOM   1374 C  CB  . SER A 1 170 ? -22.06600 28.59633 10.57586  1.000 16.42458 ? 170  SER A CB  1 
ATOM   1375 O  OG  . SER A 1 170 ? -22.55588 27.26758 10.57434  1.000 18.96168 ? 170  SER A OG  1 
ATOM   1376 N  N   . PRO A 1 171 ? -23.64777 29.51289 13.07027  1.000 17.89693 ? 171  PRO A N   1 
ATOM   1377 C  CA  . PRO A 1 171 ? -24.75712 29.17787 13.98231  1.000 17.78889 ? 171  PRO A CA  1 
ATOM   1378 C  C   . PRO A 1 171 ? -25.26338 27.75454 13.80526  1.000 17.96087 ? 171  PRO A C   1 
ATOM   1379 O  O   . PRO A 1 171 ? -25.59064 27.10302 14.80608  1.000 16.56507 ? 171  PRO A O   1 
ATOM   1380 C  CB  . PRO A 1 171 ? -25.82087 30.22662 13.63339  1.000 20.16607 ? 171  PRO A CB  1 
ATOM   1381 C  CG  . PRO A 1 171 ? -25.04446 31.38442 13.08529  1.000 19.48833 ? 171  PRO A CG  1 
ATOM   1382 C  CD  . PRO A 1 171 ? -23.84304 30.81618 12.40928  1.000 17.54169 ? 171  PRO A CD  1 
ATOM   1383 N  N   . TRP A 1 172 ? -25.31418 27.24234 12.56274  1.000 17.97732 ? 172  TRP A N   1 
ATOM   1384 C  CA  . TRP A 1 172 ? -25.65269 25.83582 12.34645  1.000 14.30032 ? 172  TRP A CA  1 
ATOM   1385 C  C   . TRP A 1 172 ? -24.80924 24.92955 13.23619  1.000 18.86759 ? 172  TRP A C   1 
ATOM   1386 O  O   . TRP A 1 172 ? -25.33349 24.04445 13.92453  1.000 15.98818 ? 172  TRP A O   1 
ATOM   1387 C  CB  . TRP A 1 172 ? -25.44491 25.44470 10.87793  1.000 15.22799 ? 172  TRP A CB  1 
ATOM   1388 C  CG  . TRP A 1 172 ? -26.39732 26.07522 9.90479   1.000 15.56349 ? 172  TRP A CG  1 
ATOM   1389 C  CD1 . TRP A 1 172 ? -26.09702 27.00766 8.94292   1.000 14.49168 ? 172  TRP A CD1 1 
ATOM   1390 C  CD2 . TRP A 1 172 ? -27.79627 25.80152 9.77491   1.000 15.10198 ? 172  TRP A CD2 1 
ATOM   1391 N  NE1 . TRP A 1 172 ? -27.22738 27.33628 8.23355   1.000 16.44481 ? 172  TRP A NE1 1 
ATOM   1392 C  CE2 . TRP A 1 172 ? -28.28613 26.61573 8.72533   1.000 15.63970 ? 172  TRP A CE2 1 
ATOM   1393 C  CE3 . TRP A 1 172 ? -28.68854 24.95666 10.44966  1.000 14.04891 ? 172  TRP A CE3 1 
ATOM   1394 C  CZ2 . TRP A 1 172 ? -29.63231 26.60867 8.33612   1.000 14.24341 ? 172  TRP A CZ2 1 
ATOM   1395 C  CZ3 . TRP A 1 172 ? -30.02516 24.94526 10.05282  1.000 15.88071 ? 172  TRP A CZ3 1 
ATOM   1396 C  CH2 . TRP A 1 172 ? -30.48178 25.76480 9.00563   1.000 13.06312 ? 172  TRP A CH2 1 
ATOM   1397 N  N   . TYR A 1 173 ? -23.48669 25.13278 13.22240  1.000 15.51864 ? 173  TYR A N   1 
ATOM   1398 C  CA  . TYR A 1 173 ? -22.60787 24.24922 13.97892  1.000 17.61544 ? 173  TYR A CA  1 
ATOM   1399 C  C   . TYR A 1 173 ? -22.67861 24.55119 15.47393  1.000 16.99398 ? 173  TYR A C   1 
ATOM   1400 O  O   . TYR A 1 173 ? -22.74331 23.63019 16.29117  1.000 18.27823 ? 173  TYR A O   1 
ATOM   1401 C  CB  . TYR A 1 173 ? -21.17473 24.35804 13.46032  1.000 13.41777 ? 173  TYR A CB  1 
ATOM   1402 C  CG  . TYR A 1 173 ? -20.24434 23.36084 14.09883  1.000 20.09688 ? 173  TYR A CG  1 
ATOM   1403 C  CD1 . TYR A 1 173 ? -20.38342 22.00411 13.85723  1.000 16.58893 ? 173  TYR A CD1 1 
ATOM   1404 C  CD2 . TYR A 1 173 ? -19.24294 23.77345 14.96901  1.000 20.22550 ? 173  TYR A CD2 1 
ATOM   1405 C  CE1 . TYR A 1 173 ? -19.54699 21.08328 14.46028  1.000 21.71072 ? 173  TYR A CE1 1 
ATOM   1406 C  CE2 . TYR A 1 173 ? -18.40074 22.86070 15.57399  1.000 19.71964 ? 173  TYR A CE2 1 
ATOM   1407 C  CZ  . TYR A 1 173 ? -18.55761 21.52173 15.31404  1.000 23.28487 ? 173  TYR A CZ  1 
ATOM   1408 O  OH  . TYR A 1 173 ? -17.71974 20.61519 15.90493  1.000 28.92547 ? 173  TYR A OH  1 
ATOM   1409 N  N   . GLN A 1 174 ? -22.71360 25.83311 15.84672  1.000 16.62622 ? 174  GLN A N   1 
ATOM   1410 C  CA  . GLN A 1 174 ? -22.80046 26.17848 17.26350  1.000 21.95098 ? 174  GLN A CA  1 
ATOM   1411 C  C   . GLN A 1 174 ? -24.03950 25.57587 17.90790  1.000 23.94588 ? 174  GLN A C   1 
ATOM   1412 O  O   . GLN A 1 174 ? -23.97227 25.04119 19.01906  1.000 20.23486 ? 174  GLN A O   1 
ATOM   1413 C  CB  . GLN A 1 174 ? -22.81850 27.69328 17.44705  1.000 24.16402 ? 174  GLN A CB  1 
ATOM   1414 C  CG  . GLN A 1 174 ? -21.55466 28.40783 17.05062  1.000 21.32342 ? 174  GLN A CG  1 
ATOM   1415 C  CD  . GLN A 1 174 ? -21.71333 29.90563 17.17940  1.000 28.00407 ? 174  GLN A CD  1 
ATOM   1416 O  OE1 . GLN A 1 174 ? -22.03209 30.40764 18.25369  1.000 36.02591 ? 174  GLN A OE1 1 
ATOM   1417 N  NE2 . GLN A 1 174 ? -21.50996 30.62930 16.07979  1.000 27.62061 ? 174  GLN A NE2 1 
ATOM   1418 N  N   . ILE A 1 175 ? -25.18101 25.64925 17.22283  1.000 19.17028 ? 175  ILE A N   1 
ATOM   1419 C  CA  . ILE A 1 175 ? -26.43875 25.24863 17.83621  1.000 17.50878 ? 175  ILE A CA  1 
ATOM   1420 C  C   . ILE A 1 175 ? -26.61545 23.73607 17.79896  1.000 20.72778 ? 175  ILE A C   1 
ATOM   1421 O  O   . ILE A 1 175 ? -26.99756 23.12087 18.79734  1.000 24.94743 ? 175  ILE A O   1 
ATOM   1422 C  CB  . ILE A 1 175 ? -27.60517 25.97625 17.15192  1.000 17.94897 ? 175  ILE A CB  1 
ATOM   1423 C  CG1 . ILE A 1 175 ? -27.48905 27.48346 17.42208  1.000 19.92458 ? 175  ILE A CG1 1 
ATOM   1424 C  CG2 . ILE A 1 175 ? -28.92204 25.42020 17.63142  1.000 16.31553 ? 175  ILE A CG2 1 
ATOM   1425 C  CD1 . ILE A 1 175 ? -28.21470 28.33732 16.43287  1.000 17.15045 ? 175  ILE A CD1 1 
ATOM   1426 N  N   . ALA A 1 176 ? -26.34331 23.10378 16.65784  1.000 22.32933 ? 176  ALA A N   1 
ATOM   1427 C  CA  . ALA A 1 176 ? -26.70344 21.70700 16.47909  1.000 20.37088 ? 176  ALA A CA  1 
ATOM   1428 C  C   . ALA A 1 176 ? -25.52013 20.77628 16.29634  1.000 18.27656 ? 176  ALA A C   1 
ATOM   1429 O  O   . ALA A 1 176 ? -25.73018 19.56380 16.19183  1.000 22.49987 ? 176  ALA A O   1 
ATOM   1430 C  CB  . ALA A 1 176 ? -27.65246 21.54702 15.28001  1.000 22.83310 ? 176  ALA A CB  1 
ATOM   1431 N  N   . GLY A 1 177 ? -24.29492 21.29233 16.25500  1.000 20.04244 ? 177  GLY A N   1 
ATOM   1432 C  CA  . GLY A 1 177 ? -23.15552 20.42594 16.03421  1.000 20.26769 ? 177  GLY A CA  1 
ATOM   1433 C  C   . GLY A 1 177 ? -23.14158 19.83074 14.63047  1.000 21.45792 ? 177  GLY A C   1 
ATOM   1434 O  O   . GLY A 1 177 ? -23.79395 20.31329 13.69992  1.000 19.74835 ? 177  GLY A O   1 
ATOM   1435 N  N   . ILE A 1 178 ? -22.38471 18.73960 14.50003  1.000 19.11307 ? 178  ILE A N   1 
ATOM   1436 C  CA  . ILE A 1 178 ? -22.22181 18.05556 13.22107  1.000 18.94400 ? 178  ILE A CA  1 
ATOM   1437 C  C   . ILE A 1 178 ? -23.53155 17.48346 12.68773  1.000 21.91813 ? 178  ILE A C   1 
ATOM   1438 O  O   . ILE A 1 178 ? -23.64796 17.24807 11.47996  1.000 18.29023 ? 178  ILE A O   1 
ATOM   1439 C  CB  . ILE A 1 178 ? -21.14978 16.94492 13.34946  1.000 20.16571 ? 178  ILE A CB  1 
ATOM   1440 C  CG1 . ILE A 1 178 ? -20.61283 16.54151 11.97150  1.000 20.04772 ? 178  ILE A CG1 1 
ATOM   1441 C  CG2 . ILE A 1 178 ? -21.70600 15.71613 14.09591  1.000 21.58888 ? 178  ILE A CG2 1 
ATOM   1442 C  CD1 . ILE A 1 178 ? -19.51400 15.48432 12.01921  1.000 26.04543 ? 178  ILE A CD1 1 
ATOM   1443 N  N   . ASP A 1 179 ? -24.52862 17.25964 13.55592  1.000 18.24057 ? 179  ASP A N   1 
ATOM   1444 C  CA  . ASP A 1 179 ? -25.77720 16.63301 13.12913  1.000 19.91585 ? 179  ASP A CA  1 
ATOM   1445 C  C   . ASP A 1 179 ? -26.53379 17.44591 12.07750  1.000 16.30460 ? 179  ASP A C   1 
ATOM   1446 O  O   . ASP A 1 179 ? -27.34413 16.87060 11.34144  1.000 16.27676 ? 179  ASP A O   1 
ATOM   1447 C  CB  . ASP A 1 179 ? -26.69640 16.40246 14.33292  1.000 18.95257 ? 179  ASP A CB  1 
ATOM   1448 C  CG  . ASP A 1 179 ? -26.28551 15.19211 15.16454  1.000 27.35970 ? 179  ASP A CG  1 
ATOM   1449 O  OD1 . ASP A 1 179 ? -25.48391 14.36487 14.67591  1.000 27.21666 ? 179  ASP A OD1 1 
ATOM   1450 O  OD2 . ASP A 1 179 ? -26.76416 15.07407 16.31258  1.000 31.76059 ? 179  ASP A OD2 1 
ATOM   1451 N  N   . TYR A 1 180 ? -26.32466 18.76521 12.00274  1.000 13.63468 ? 180  TYR A N   1 
ATOM   1452 C  CA  . TYR A 1 180 ? -27.05432 19.53089 10.99649  1.000 12.39174 ? 180  TYR A CA  1 
ATOM   1453 C  C   . TYR A 1 180 ? -26.64458 19.08986 9.60251   1.000 14.37329 ? 180  TYR A C   1 
ATOM   1454 O  O   . TYR A 1 180 ? -27.48681 19.02269 8.70038   1.000 15.16045 ? 180  TYR A O   1 
ATOM   1455 C  CB  . TYR A 1 180 ? -26.86216 21.04055 11.20453  1.000 12.54971 ? 180  TYR A CB  1 
ATOM   1456 C  CG  . TYR A 1 180 ? -25.63741 21.67415 10.55149  1.000 13.15406 ? 180  TYR A CG  1 
ATOM   1457 C  CD1 . TYR A 1 180 ? -25.69591 22.16754 9.24845   1.000 12.93646 ? 180  TYR A CD1 1 
ATOM   1458 C  CD2 . TYR A 1 180 ? -24.43839 21.81563 11.25065  1.000 14.45661 ? 180  TYR A CD2 1 
ATOM   1459 C  CE1 . TYR A 1 180 ? -24.59409 22.75957 8.65452   1.000 14.23329 ? 180  TYR A CE1 1 
ATOM   1460 C  CE2 . TYR A 1 180 ? -23.31990 22.40295 10.65792  1.000 12.54919 ? 180  TYR A CE2 1 
ATOM   1461 C  CZ  . TYR A 1 180 ? -23.40930 22.87522 9.36025   1.000 12.67226 ? 180  TYR A CZ  1 
ATOM   1462 O  OH  . TYR A 1 180 ? -22.33162 23.47157 8.75314   1.000 9.62216  ? 180  TYR A OH  1 
ATOM   1463 N  N   . ILE A 1 181 ? -25.38203 18.69698 9.43794   1.000 12.97203 ? 181  ILE A N   1 
ATOM   1464 C  CA  . ILE A 1 181 ? -24.91771 18.17073 8.15863   1.000 13.75201 ? 181  ILE A CA  1 
ATOM   1465 C  C   . ILE A 1 181 ? -25.57131 16.82876 7.86035   1.000 17.47563 ? 181  ILE A C   1 
ATOM   1466 O  O   . ILE A 1 181 ? -26.06279 16.59732 6.75016   1.000 13.67763 ? 181  ILE A O   1 
ATOM   1467 C  CB  . ILE A 1 181 ? -23.38471 18.05688 8.15668   1.000 14.83739 ? 181  ILE A CB  1 
ATOM   1468 C  CG1 . ILE A 1 181 ? -22.75994 19.44508 8.30947   1.000 14.61671 ? 181  ILE A CG1 1 
ATOM   1469 C  CG2 . ILE A 1 181 ? -22.89972 17.35592 6.87592   1.000 10.06183 ? 181  ILE A CG2 1 
ATOM   1470 C  CD1 . ILE A 1 181 ? -21.26943 19.41554 8.60058   1.000 12.16289 ? 181  ILE A CD1 1 
ATOM   1471 N  N   . LYS A 1 182 ? -25.56737 15.91262 8.83998   1.000 16.88781 ? 182  LYS A N   1 
ATOM   1472 C  CA  . LYS A 1 182 ? -26.16129 14.59363 8.62492   1.000 16.70996 ? 182  LYS A CA  1 
ATOM   1473 C  C   . LYS A 1 182 ? -27.65344 14.69854 8.33905   1.000 13.84251 ? 182  LYS A C   1 
ATOM   1474 O  O   . LYS A 1 182 ? -28.17535 14.00132 7.46223   1.000 16.04702 ? 182  LYS A O   1 
ATOM   1475 C  CB  . LYS A 1 182 ? -25.94183 13.69727 9.84680   1.000 21.91440 ? 182  LYS A CB  1 
ATOM   1476 C  CG  . LYS A 1 182 ? -24.52537 13.67481 10.38668  1.000 21.77926 ? 182  LYS A CG  1 
ATOM   1477 C  CD  . LYS A 1 182 ? -24.42814 12.75465 11.61529  1.000 28.50832 ? 182  LYS A CD  1 
ATOM   1478 C  CE  . LYS A 1 182 ? -23.00004 12.74161 12.15542  1.000 32.97298 ? 182  LYS A CE  1 
ATOM   1479 N  NZ  . LYS A 1 182 ? -22.74693 11.63187 13.11309  1.000 36.40780 ? 182  LYS A NZ  1 
ATOM   1480 N  N   . VAL A 1 183 ? -28.35419 15.54983 9.08930   1.000 13.23596 ? 183  VAL A N   1 
ATOM   1481 C  CA  . VAL A 1 183 ? -29.79366 15.71722 8.90922   1.000 16.47519 ? 183  VAL A CA  1 
ATOM   1482 C  C   . VAL A 1 183 ? -30.09752 16.28157 7.52335   1.000 16.09508 ? 183  VAL A C   1 
ATOM   1483 O  O   . VAL A 1 183 ? -31.04186 15.84242 6.85198   1.000 12.95977 ? 183  VAL A O   1 
ATOM   1484 C  CB  . VAL A 1 183 ? -30.35708 16.60442 10.03587  1.000 13.53692 ? 183  VAL A CB  1 
ATOM   1485 C  CG1 . VAL A 1 183 ? -31.66636 17.26919 9.62808   1.000 13.76094 ? 183  VAL A CG1 1 
ATOM   1486 C  CG2 . VAL A 1 183 ? -30.55062 15.77068 11.29922  1.000 19.11198 ? 183  VAL A CG2 1 
ATOM   1487 N  N   . ALA A 1 184 ? -29.28783 17.24157 7.06541   1.000 13.19949 ? 184  ALA A N   1 
ATOM   1488 C  CA  . ALA A 1 184 ? -29.49791 17.83704 5.74750   1.000 12.06418 ? 184  ALA A CA  1 
ATOM   1489 C  C   . ALA A 1 184 ? -29.47493 16.77705 4.64972   1.000 11.36607 ? 184  ALA A C   1 
ATOM   1490 O  O   . ALA A 1 184 ? -30.38662 16.70738 3.81998   1.000 10.28344 ? 184  ALA A O   1 
ATOM   1491 C  CB  . ALA A 1 184 ? -28.44321 18.91849 5.48419   1.000 9.59415  ? 184  ALA A CB  1 
ATOM   1492 N  N   . PHE A 1 185 ? -28.44220 15.93254 4.63340   1.000 11.98884 ? 185  PHE A N   1 
ATOM   1493 C  CA  . PHE A 1 185 ? -28.36443 14.90537 3.59788   1.000 11.00508 ? 185  PHE A CA  1 
ATOM   1494 C  C   . PHE A 1 185 ? -29.45751 13.85527 3.76549   1.000 11.96804 ? 185  PHE A C   1 
ATOM   1495 O  O   . PHE A 1 185 ? -30.04231 13.40131 2.77596   1.000 12.68822 ? 185  PHE A O   1 
ATOM   1496 C  CB  . PHE A 1 185 ? -26.97971 14.23895 3.60360   1.000 10.72351 ? 185  PHE A CB  1 
ATOM   1497 C  CG  . PHE A 1 185 ? -25.91151 15.06071 2.93728   1.000 12.05039 ? 185  PHE A CG  1 
ATOM   1498 C  CD1 . PHE A 1 185 ? -25.74514 15.02714 1.55739   1.000 11.27100 ? 185  PHE A CD1 1 
ATOM   1499 C  CD2 . PHE A 1 185 ? -25.10011 15.90303 3.68684   1.000 10.41213 ? 185  PHE A CD2 1 
ATOM   1500 C  CE1 . PHE A 1 185 ? -24.75776 15.80351 0.93741   1.000 10.29396 ? 185  PHE A CE1 1 
ATOM   1501 C  CE2 . PHE A 1 185 ? -24.11183 16.68348 3.07905   1.000 11.47151 ? 185  PHE A CE2 1 
ATOM   1502 C  CZ  . PHE A 1 185 ? -23.94543 16.63599 1.69737   1.000 10.86963 ? 185  PHE A CZ  1 
ATOM   1503 N  N   . GLN A 1 186 ? -29.73660 13.44190 5.00420   1.000 13.79040 ? 186  GLN A N   1 
ATOM   1504 C  CA  . GLN A 1 186 ? -30.72996 12.39200 5.20988   1.000 18.17348 ? 186  GLN A CA  1 
ATOM   1505 C  C   . GLN A 1 186 ? -32.11077 12.86975 4.78673   1.000 13.46673 ? 186  GLN A C   1 
ATOM   1506 O  O   . GLN A 1 186 ? -32.88884 12.11138 4.19331   1.000 14.50065 ? 186  GLN A O   1 
ATOM   1507 C  CB  . GLN A 1 186 ? -30.74314 11.94516 6.68045   1.000 19.50632 ? 186  GLN A CB  1 
ATOM   1508 C  CG  . GLN A 1 186 ? -29.47146 11.23898 7.16928   1.000 17.49198 ? 186  GLN A CG  1 
ATOM   1509 C  CD  . GLN A 1 186 ? -29.33926 9.77852  6.70217   1.000 33.80038 ? 186  GLN A CD  1 
ATOM   1510 O  OE1 . GLN A 1 186 ? -30.03624 9.32166  5.77965   1.000 28.43021 ? 186  GLN A OE1 1 
ATOM   1511 N  NE2 . GLN A 1 186 ? -28.42709 9.04245  7.34183   1.000 31.46655 ? 186  GLN A NE2 1 
ATOM   1512 N  N   . ALA A 1 187 ? -32.42627 14.13096 5.06744   1.000 14.15786 ? 187  ALA A N   1 
ATOM   1513 C  CA  . ALA A 1 187 ? -33.71854 14.65916 4.65049   1.000 14.92734 ? 187  ALA A CA  1 
ATOM   1514 C  C   . ALA A 1 187 ? -33.79601 14.77080 3.13523   1.000 14.22983 ? 187  ALA A C   1 
ATOM   1515 O  O   . ALA A 1 187 ? -34.84858 14.51141 2.54231   1.000 14.27144 ? 187  ALA A O   1 
ATOM   1516 C  CB  . ALA A 1 187 ? -33.97659 16.01837 5.30052   1.000 11.96459 ? 187  ALA A CB  1 
ATOM   1517 N  N   . ALA A 1 188 ? -32.70351 15.17262 2.48745   1.000 11.72947 ? 188  ALA A N   1 
ATOM   1518 C  CA  . ALA A 1 188 ? -32.75271 15.29693 1.03309   1.000 14.65331 ? 188  ALA A CA  1 
ATOM   1519 C  C   . ALA A 1 188 ? -33.00375 13.93958 0.39318   1.000 13.13146 ? 188  ALA A C   1 
ATOM   1520 O  O   . ALA A 1 188 ? -33.85278 13.80662 -0.49908  1.000 14.58905 ? 188  ALA A O   1 
ATOM   1521 C  CB  . ALA A 1 188 ? -31.45870 15.93024 0.50230   1.000 10.04689 ? 188  ALA A CB  1 
ATOM   1522 N  N   . ARG A 1 189 ? -32.30219 12.90711 0.86939   1.000 12.01370 ? 189  ARG A N   1 
ATOM   1523 C  CA  . ARG A 1 189 ? -32.52346 11.56543 0.34303   1.000 11.71731 ? 189  ARG A CA  1 
ATOM   1524 C  C   . ARG A 1 189 ? -33.93155 11.07251 0.65209   1.000 12.98616 ? 189  ARG A C   1 
ATOM   1525 O  O   . ARG A 1 189 ? -34.57975 10.45339 -0.19919  1.000 13.65222 ? 189  ARG A O   1 
ATOM   1526 C  CB  . ARG A 1 189 ? -31.48246 10.60204 0.91578   1.000 13.58626 ? 189  ARG A CB  1 
ATOM   1527 C  CG  . ARG A 1 189 ? -31.69833 9.14662  0.50467   1.000 16.55826 ? 189  ARG A CG  1 
ATOM   1528 C  CD  . ARG A 1 189 ? -31.45926 8.95026  -0.99410  1.000 13.45129 ? 189  ARG A CD  1 
ATOM   1529 N  NE  . ARG A 1 189 ? -30.04829 9.10308  -1.34399  1.000 16.94096 ? 189  ARG A NE  1 
ATOM   1530 C  CZ  . ARG A 1 189 ? -29.59667 9.81015  -2.38537  1.000 16.51348 ? 189  ARG A CZ  1 
ATOM   1531 N  NH1 . ARG A 1 189 ? -30.44156 10.44619 -3.18421  1.000 9.68759  ? 189  ARG A NH1 1 
ATOM   1532 N  NH2 . ARG A 1 189 ? -28.29290 9.88721  -2.62949  1.000 14.32957 ? 189  ARG A NH2 1 
ATOM   1533 N  N   . LYS A 1 190 ? -34.41853 11.33005 1.86805   1.000 13.87389 ? 190  LYS A N   1 
ATOM   1534 C  CA  . LYS A 1 190 ? -35.72555 10.80866 2.27342   1.000 13.97182 ? 190  LYS A CA  1 
ATOM   1535 C  C   . LYS A 1 190 ? -36.83895 11.35622 1.39140   1.000 14.50944 ? 190  LYS A C   1 
ATOM   1536 O  O   . LYS A 1 190 ? -37.64533 10.59476 0.85319   1.000 15.93102 ? 190  LYS A O   1 
ATOM   1537 C  CB  . LYS A 1 190 ? -36.00439 11.14480 3.73820   1.000 14.63387 ? 190  LYS A CB  1 
ATOM   1538 C  CG  . LYS A 1 190 ? -37.40784 10.74042 4.21447   1.000 15.26487 ? 190  LYS A CG  1 
ATOM   1539 C  CD  . LYS A 1 190 ? -37.61027 11.09252 5.67951   1.000 20.48416 ? 190  LYS A CD  1 
ATOM   1540 C  CE  . LYS A 1 190 ? -39.01612 10.72678 6.16033   1.000 22.34657 ? 190  LYS A CE  1 
ATOM   1541 N  NZ  . LYS A 1 190 ? -39.18625 11.13375 7.57354   1.000 27.57921 ? 190  LYS A NZ  1 
ATOM   1542 N  N   . TYR A 1 191 ? -36.89710 12.68072 1.22439   1.000 14.94376 ? 191  TYR A N   1 
ATOM   1543 C  CA  . TYR A 1 191 ? -37.97389 13.29250 0.45493   1.000 14.82546 ? 191  TYR A CA  1 
ATOM   1544 C  C   . TYR A 1 191 ? -37.70389 13.33981 -1.04303  1.000 19.03705 ? 191  TYR A C   1 
ATOM   1545 O  O   . TYR A 1 191 ? -38.65147 13.53203 -1.81384  1.000 17.26399 ? 191  TYR A O   1 
ATOM   1546 C  CB  . TYR A 1 191 ? -38.26503 14.69854 0.99009   1.000 14.34523 ? 191  TYR A CB  1 
ATOM   1547 C  CG  . TYR A 1 191 ? -38.73619 14.63817 2.42376   1.000 15.03268 ? 191  TYR A CG  1 
ATOM   1548 C  CD1 . TYR A 1 191 ? -39.97184 14.08031 2.74219   1.000 19.06523 ? 191  TYR A CD1 1 
ATOM   1549 C  CD2 . TYR A 1 191 ? -37.93047 15.08274 3.46121   1.000 14.79218 ? 191  TYR A CD2 1 
ATOM   1550 C  CE1 . TYR A 1 191 ? -40.40321 13.98724 4.05464   1.000 18.00303 ? 191  TYR A CE1 1 
ATOM   1551 C  CE2 . TYR A 1 191 ? -38.35129 14.99348 4.78065   1.000 21.17389 ? 191  TYR A CE2 1 
ATOM   1552 C  CZ  . TYR A 1 191 ? -39.59040 14.44324 5.06852   1.000 20.96797 ? 191  TYR A CZ  1 
ATOM   1553 O  OH  . TYR A 1 191 ? -40.01611 14.35726 6.37469   1.000 25.40679 ? 191  TYR A OH  1 
ATOM   1554 N  N   . GLY A 1 192 ? -36.46010 13.13056 -1.48035  1.000 18.36701 ? 192  GLY A N   1 
ATOM   1555 C  CA  . GLY A 1 192 ? -36.15048 13.19226 -2.89775  1.000 13.20365 ? 192  GLY A CA  1 
ATOM   1556 C  C   . GLY A 1 192 ? -35.95507 11.84801 -3.56448  1.000 20.28422 ? 192  GLY A C   1 
ATOM   1557 O  O   . GLY A 1 192 ? -36.01720 11.74907 -4.79292  1.000 20.24377 ? 192  GLY A O   1 
ATOM   1558 N  N   . GLY A 1 193 ? -35.70534 10.80283 -2.77891  1.000 18.00334 ? 193  GLY A N   1 
ATOM   1559 C  CA  . GLY A 1 193 ? -35.51707 9.48597  -3.35057  1.000 20.29324 ? 193  GLY A CA  1 
ATOM   1560 C  C   . GLY A 1 193 ? -34.08728 9.23473  -3.78759  1.000 23.93164 ? 193  GLY A C   1 
ATOM   1561 O  O   . GLY A 1 193 ? -33.17896 10.04961 -3.59910  1.000 18.76939 ? 193  GLY A O   1 
ATOM   1562 N  N   . ASP A 1 194 ? -33.89388 8.05911  -4.39263  1.000 23.30968 ? 194  ASP A N   1 
ATOM   1563 C  CA  . ASP A 1 194 ? -32.56707 7.55705  -4.72198  1.000 24.75271 ? 194  ASP A CA  1 
ATOM   1564 C  C   . ASP A 1 194 ? -32.01717 8.11182  -6.02688  1.000 25.72804 ? 194  ASP A C   1 
ATOM   1565 O  O   . ASP A 1 194 ? -30.84435 7.87423  -6.33230  1.000 23.59859 ? 194  ASP A O   1 
ATOM   1566 C  CB  . ASP A 1 194 ? -32.57607 6.02528  -4.81752  1.000 32.62319 ? 194  ASP A CB  1 
ATOM   1567 C  CG  . ASP A 1 194 ? -33.04712 5.35911  -3.54121  1.000 37.78090 ? 194  ASP A CG  1 
ATOM   1568 O  OD1 . ASP A 1 194 ? -32.76237 5.88497  -2.44352  1.000 37.24694 ? 194  ASP A OD1 1 
ATOM   1569 O  OD2 . ASP A 1 194 ? -33.70258 4.30044  -3.63999  1.000 50.38691 ? 194  ASP A OD2 1 
ATOM   1570 N  N   . ASN A 1 195 ? -32.82182 8.82302  -6.80746  1.000 21.22535 ? 195  ASN A N   1 
ATOM   1571 C  CA  . ASN A 1 195 ? -32.35726 9.26601  -8.11051  1.000 23.89992 ? 195  ASN A CA  1 
ATOM   1572 C  C   . ASN A 1 195 ? -31.72242 10.65358 -8.09605  1.000 21.91150 ? 195  ASN A C   1 
ATOM   1573 O  O   . ASN A 1 195 ? -31.03445 11.00176 -9.05770  1.000 27.38483 ? 195  ASN A O   1 
ATOM   1574 C  CB  . ASN A 1 195 ? -33.51217 9.22845  -9.10878  1.000 26.69910 ? 195  ASN A CB  1 
ATOM   1575 C  CG  . ASN A 1 195 ? -33.98466 7.81656  -9.38237  1.000 36.03927 ? 195  ASN A CG  1 
ATOM   1576 O  OD1 . ASN A 1 195 ? -33.24143 6.85539  -9.17634  1.000 33.55055 ? 195  ASN A OD1 1 
ATOM   1577 N  ND2 . ASN A 1 195 ? -35.22552 7.68022  -9.83996  1.000 33.87302 ? 195  ASN A ND2 1 
ATOM   1578 N  N   . ILE A 1 196 ? -31.91986 11.45924 -7.04124  1.000 14.19562 ? 196  ILE A N   1 
ATOM   1579 C  CA  . ILE A 1 196 ? -31.25914 12.75878 -6.99559  1.000 13.89358 ? 196  ILE A CA  1 
ATOM   1580 C  C   . ILE A 1 196 ? -29.87865 12.56009 -6.38874  1.000 14.76566 ? 196  ILE A C   1 
ATOM   1581 O  O   . ILE A 1 196 ? -29.65726 11.66232 -5.56374  1.000 15.61188 ? 196  ILE A O   1 
ATOM   1582 C  CB  . ILE A 1 196 ? -32.07964 13.81971 -6.22541  1.000 12.08798 ? 196  ILE A CB  1 
ATOM   1583 C  CG1 . ILE A 1 196 ? -32.17262 13.48324 -4.73537  1.000 10.26014 ? 196  ILE A CG1 1 
ATOM   1584 C  CG2 . ILE A 1 196 ? -33.47592 13.99800 -6.83568  1.000 13.22206 ? 196  ILE A CG2 1 
ATOM   1585 C  CD1 . ILE A 1 196 ? -32.69685 14.64041 -3.90130  1.000 9.50687  ? 196  ILE A CD1 1 
ATOM   1586 N  N   . LYS A 1 197 ? -28.93352 13.39771 -6.80836  1.000 11.18995 ? 197  LYS A N   1 
ATOM   1587 C  CA  . LYS A 1 197 ? -27.53574 13.25906 -6.42953  1.000 10.22474 ? 197  LYS A CA  1 
ATOM   1588 C  C   . LYS A 1 197 ? -27.15293 14.37089 -5.46484  1.000 12.29086 ? 197  LYS A C   1 
ATOM   1589 O  O   . LYS A 1 197 ? -27.39830 15.55140 -5.74023  1.000 11.71086 ? 197  LYS A O   1 
ATOM   1590 C  CB  . LYS A 1 197 ? -26.64035 13.28071 -7.66852  1.000 13.24840 ? 197  LYS A CB  1 
ATOM   1591 C  CG  . LYS A 1 197 ? -26.93776 12.16454 -8.65648  1.000 15.85123 ? 197  LYS A CG  1 
ATOM   1592 C  CD  . LYS A 1 197 ? -26.49215 10.81045 -8.11979  1.000 22.75313 ? 197  LYS A CD  1 
ATOM   1593 C  CE  . LYS A 1 197 ? -27.14252 9.67391  -8.90964  1.000 36.96503 ? 197  LYS A CE  1 
ATOM   1594 N  NZ  . LYS A 1 197 ? -26.69229 8.33600  -8.43604  1.000 35.98627 ? 197  LYS A NZ  1 
ATOM   1595 N  N   . LEU A 1 198 ? -26.53868 13.99148 -4.34487  1.000 11.82503 ? 198  LEU A N   1 
ATOM   1596 C  CA  . LEU A 1 198 ? -26.36464 14.87047 -3.19605  1.000 11.18212 ? 198  LEU A CA  1 
ATOM   1597 C  C   . LEU A 1 198 ? -24.89663 15.23008 -3.02682  1.000 11.65351 ? 198  LEU A C   1 
ATOM   1598 O  O   . LEU A 1 198 ? -24.04687 14.33891 -2.90921  1.000 11.98287 ? 198  LEU A O   1 
ATOM   1599 C  CB  . LEU A 1 198 ? -26.89830 14.20533 -1.92523  1.000 12.44289 ? 198  LEU A CB  1 
ATOM   1600 C  CG  . LEU A 1 198 ? -28.32508 13.64760 -2.04020  1.000 11.21149 ? 198  LEU A CG  1 
ATOM   1601 C  CD1 . LEU A 1 198 ? -28.76215 13.07614 -0.69157  1.000 12.01615 ? 198  LEU A CD1 1 
ATOM   1602 C  CD2 . LEU A 1 198 ? -29.30967 14.73287 -2.51132  1.000 12.18319 ? 198  LEU A CD2 1 
ATOM   1603 N  N   . TYR A 1 199 ? -24.61125 16.53199 -2.97155  1.000 9.53175  ? 199  TYR A N   1 
ATOM   1604 C  CA  . TYR A 1 199 ? -23.24894 17.04115 -2.98399  1.000 8.14900  ? 199  TYR A CA  1 
ATOM   1605 C  C   . TYR A 1 199 ? -22.94470 17.88147 -1.75282  1.000 10.04505 ? 199  TYR A C   1 
ATOM   1606 O  O   . TYR A 1 199 ? -23.79386 18.62903 -1.25451  1.000 8.81434  ? 199  TYR A O   1 
ATOM   1607 C  CB  . TYR A 1 199 ? -22.98415 17.89351 -4.24825  1.000 12.32223 ? 199  TYR A CB  1 
ATOM   1608 C  CG  . TYR A 1 199 ? -23.01042 17.06498 -5.49264  1.000 11.06915 ? 199  TYR A CG  1 
ATOM   1609 C  CD1 . TYR A 1 199 ? -24.21658 16.62024 -6.01504  1.000 9.42929  ? 199  TYR A CD1 1 
ATOM   1610 C  CD2 . TYR A 1 199 ? -21.82954 16.66397 -6.10941  1.000 9.07992  ? 199  TYR A CD2 1 
ATOM   1611 C  CE1 . TYR A 1 199 ? -24.25577 15.82989 -7.14104  1.000 12.07201 ? 199  TYR A CE1 1 
ATOM   1612 C  CE2 . TYR A 1 199 ? -21.85566 15.85970 -7.23702  1.000 11.14209 ? 199  TYR A CE2 1 
ATOM   1613 C  CZ  . TYR A 1 199 ? -23.07822 15.44686 -7.74860  1.000 11.25016 ? 199  TYR A CZ  1 
ATOM   1614 O  OH  . TYR A 1 199 ? -23.13476 14.65631 -8.86997  1.000 8.36609  ? 199  TYR A OH  1 
ATOM   1615 N  N   . MET A 1 200 ? -21.70258 17.77266 -1.28910  1.000 8.88527  ? 200  MET A N   1 
ATOM   1616 C  CA  . MET A 1 200 ? -21.11963 18.74018 -0.37318  1.000 11.79707 ? 200  MET A CA  1 
ATOM   1617 C  C   . MET A 1 200 ? -20.29861 19.72047 -1.19836  1.000 12.92118 ? 200  MET A C   1 
ATOM   1618 O  O   . MET A 1 200 ? -19.42525 19.30862 -1.97202  1.000 9.91838  ? 200  MET A O   1 
ATOM   1619 C  CB  . MET A 1 200 ? -20.24073 18.06140 0.68409   1.000 11.35916 ? 200  MET A CB  1 
ATOM   1620 C  CG  . MET A 1 200 ? -19.73309 19.01965 1.75938   1.000 11.72729 ? 200  MET A CG  1 
ATOM   1621 S  SD  . MET A 1 200 ? -18.81698 18.15861 3.06458   1.000 16.60351 ? 200  MET A SD  1 
ATOM   1622 C  CE  . MET A 1 200 ? -20.13756 17.37573 3.98918   1.000 13.10117 ? 200  MET A CE  1 
ATOM   1623 N  N   . ASN A 1 201 ? -20.56395 21.00876 -1.01751  1.000 10.05176 ? 201  ASN A N   1 
ATOM   1624 C  CA  . ASN A 1 201 ? -20.03287 22.05775 -1.87841  1.000 9.00626  ? 201  ASN A CA  1 
ATOM   1625 C  C   . ASN A 1 201 ? -19.11182 22.97008 -1.07629  1.000 9.17635  ? 201  ASN A C   1 
ATOM   1626 O  O   . ASN A 1 201 ? -19.43428 23.33696 0.05700   1.000 10.93158 ? 201  ASN A O   1 
ATOM   1627 C  CB  . ASN A 1 201 ? -21.19764 22.85242 -2.47642  1.000 7.93511  ? 201  ASN A CB  1 
ATOM   1628 C  CG  . ASN A 1 201 ? -20.75257 23.94133 -3.42115  1.000 10.24460 ? 201  ASN A CG  1 
ATOM   1629 O  OD1 . ASN A 1 201 ? -20.16812 24.94487 -3.00636  1.000 12.47794 ? 201  ASN A OD1 1 
ATOM   1630 N  ND2 . ASN A 1 201 ? -21.05966 23.76666 -4.69824  1.000 11.87886 ? 201  ASN A ND2 1 
ATOM   1631 N  N   . ASP A 1 202 ? -17.97136 23.35099 -1.65798  1.000 10.51702 ? 202  ASP A N   1 
ATOM   1632 C  CA  . ASP A 1 202 ? -17.05404 24.24587 -0.95743  1.000 8.55785  ? 202  ASP A CA  1 
ATOM   1633 C  C   . ASP A 1 202 ? -16.12611 24.92951 -1.95583  1.000 9.32291  ? 202  ASP A C   1 
ATOM   1634 O  O   . ASP A 1 202 ? -16.05886 24.56410 -3.13080  1.000 10.17007 ? 202  ASP A O   1 
ATOM   1635 C  CB  . ASP A 1 202 ? -16.24768 23.50652 0.12199   1.000 6.23701  ? 202  ASP A CB  1 
ATOM   1636 C  CG  . ASP A 1 202 ? -16.16845 24.29409 1.42145   1.000 10.39102 ? 202  ASP A CG  1 
ATOM   1637 O  OD1 . ASP A 1 202 ? -15.93873 25.52725 1.34883   1.000 9.47132  ? 202  ASP A OD1 1 
ATOM   1638 O  OD2 . ASP A 1 202 ? -16.35880 23.69426 2.51009   1.000 7.64516  ? 202  ASP A OD2 1 
ATOM   1639 N  N   . TYR A 1 203 ? -15.43973 25.96128 -1.47325  1.000 10.38002 ? 203  TYR A N   1 
ATOM   1640 C  CA  . TYR A 1 203 ? -14.40496 26.66112 -2.22285  1.000 9.69414  ? 203  TYR A CA  1 
ATOM   1641 C  C   . TYR A 1 203 ? -13.05851 26.29813 -1.61856  1.000 12.89396 ? 203  TYR A C   1 
ATOM   1642 O  O   . TYR A 1 203 ? -12.98280 25.82067 -0.47947  1.000 9.38738  ? 203  TYR A O   1 
ATOM   1643 C  CB  . TYR A 1 203 ? -14.61031 28.18804 -2.19672  1.000 9.57637  ? 203  TYR A CB  1 
ATOM   1644 C  CG  . TYR A 1 203 ? -14.44323 28.78833 -0.81603  1.000 12.61039 ? 203  TYR A CG  1 
ATOM   1645 C  CD1 . TYR A 1 203 ? -13.19446 29.21393 -0.36969  1.000 11.73332 ? 203  TYR A CD1 1 
ATOM   1646 C  CD2 . TYR A 1 203 ? -15.53205 28.90331 0.05588   1.000 10.82609 ? 203  TYR A CD2 1 
ATOM   1647 C  CE1 . TYR A 1 203 ? -13.02404 29.74879 0.91284   1.000 12.50401 ? 203  TYR A CE1 1 
ATOM   1648 C  CE2 . TYR A 1 203 ? -15.37894 29.43851 1.33631   1.000 13.50169 ? 203  TYR A CE2 1 
ATOM   1649 C  CZ  . TYR A 1 203 ? -14.11346 29.85774 1.75689   1.000 14.87294 ? 203  TYR A CZ  1 
ATOM   1650 O  OH  . TYR A 1 203 ? -13.93827 30.38000 3.02071   1.000 15.02428 ? 203  TYR A OH  1 
ATOM   1651 N  N   . ASN A 1 204 ? -11.99210 26.52291 -2.39283  1.000 12.33678 ? 204  ASN A N   1 
ATOM   1652 C  CA  . ASN A 1 204 ? -10.64343 26.17957 -1.94324  1.000 15.40777 ? 204  ASN A CA  1 
ATOM   1653 C  C   . ASN A 1 204 ? -10.57730 24.71932 -1.51300  1.000 11.40157 ? 204  ASN A C   1 
ATOM   1654 O  O   . ASN A 1 204 ? -9.89011  24.35563 -0.55499  1.000 14.51436 ? 204  ASN A O   1 
ATOM   1655 C  CB  . ASN A 1 204 ? -10.18216 27.10469 -0.80972  1.000 10.63104 ? 204  ASN A CB  1 
ATOM   1656 C  CG  . ASN A 1 204 ? -9.83317  28.48333 -1.30946  1.000 16.77487 ? 204  ASN A CG  1 
ATOM   1657 O  OD1 . ASN A 1 204 ? -10.03375 28.79117 -2.48754  1.000 13.58009 ? 204  ASN A OD1 1 
ATOM   1658 N  ND2 . ASN A 1 204 ? -9.30148  29.32245 -0.42839  1.000 16.53231 ? 204  ASN A ND2 1 
ATOM   1659 N  N   . THR A 1 205 ? -11.30770 23.86656 -2.23008  1.000 12.08325 ? 205  THR A N   1 
ATOM   1660 C  CA  . THR A 1 205 ? -11.22540 22.43632 -1.96632  1.000 10.49860 ? 205  THR A CA  1 
ATOM   1661 C  C   . THR A 1 205 ? -9.83916  21.87585 -2.25509  1.000 15.04059 ? 205  THR A C   1 
ATOM   1662 O  O   . THR A 1 205 ? -9.54333  20.75178 -1.82581  1.000 11.77470 ? 205  THR A O   1 
ATOM   1663 C  CB  . THR A 1 205 ? -12.25389 21.66897 -2.80120  1.000 12.28248 ? 205  THR A CB  1 
ATOM   1664 O  OG1 . THR A 1 205 ? -12.10473 22.03386 -4.17335  1.000 10.25098 ? 205  THR A OG1 1 
ATOM   1665 C  CG2 . THR A 1 205 ? -13.70209 21.95877 -2.32777  1.000 9.75597  ? 205  THR A CG2 1 
ATOM   1666 N  N   . GLU A 1 206 ? -8.99560  22.62697 -2.96461  1.000 11.51155 ? 206  GLU A N   1 
ATOM   1667 C  CA  . GLU A 1 206 ? -7.64550  22.21360 -3.31732  1.000 17.35524 ? 206  GLU A CA  1 
ATOM   1668 C  C   . GLU A 1 206 ? -6.62251  22.52756 -2.23736  1.000 19.13643 ? 206  GLU A C   1 
ATOM   1669 O  O   . GLU A 1 206 ? -5.46847  22.10460 -2.35783  1.000 21.20034 ? 206  GLU A O   1 
ATOM   1670 C  CB  . GLU A 1 206 ? -7.19950  22.90370 -4.62160  1.000 18.16555 ? 206  GLU A CB  1 
ATOM   1671 C  CG  . GLU A 1 206 ? -8.20396  22.84897 -5.78018  1.000 13.84471 ? 206  GLU A CG  1 
ATOM   1672 C  CD  . GLU A 1 206 ? -9.29882  23.90352 -5.69239  1.000 19.42347 ? 206  GLU A CD  1 
ATOM   1673 O  OE1 . GLU A 1 206 ? -9.25392  24.75958 -4.77378  1.000 16.36722 ? 206  GLU A OE1 1 
ATOM   1674 O  OE2 . GLU A 1 206 ? -10.21562 23.87342 -6.54871  1.000 18.44633 ? 206  GLU A OE2 1 
ATOM   1675 N  N   . VAL A 1 207 ? -7.00534  23.25764 -1.19578  1.000 18.04858 ? 207  VAL A N   1 
ATOM   1676 C  CA  . VAL A 1 207 ? -6.05971  23.92098 -0.30860  1.000 16.60071 ? 207  VAL A CA  1 
ATOM   1677 C  C   . VAL A 1 207 ? -6.04805  23.20151 1.02870   1.000 19.60849 ? 207  VAL A C   1 
ATOM   1678 O  O   . VAL A 1 207 ? -7.10618  23.00482 1.64247   1.000 16.81294 ? 207  VAL A O   1 
ATOM   1679 C  CB  . VAL A 1 207 ? -6.41861  25.40547 -0.13130  1.000 19.02451 ? 207  VAL A CB  1 
ATOM   1680 C  CG1 . VAL A 1 207 ? -5.32426  26.13652 0.66736   1.000 18.68845 ? 207  VAL A CG1 1 
ATOM   1681 C  CG2 . VAL A 1 207 ? -6.62482  26.04260 -1.49388  1.000 15.79325 ? 207  VAL A CG2 1 
ATOM   1682 N  N   . GLU A 1 208 ? -4.84236  22.80849 1.48477   1.000 13.56500 ? 208  GLU A N   1 
ATOM   1683 C  CA  . GLU A 1 208 ? -4.74680  22.26322 2.82876   1.000 17.75506 ? 208  GLU A CA  1 
ATOM   1684 C  C   . GLU A 1 208 ? -4.70717  23.40767 3.83951   1.000 17.55393 ? 208  GLU A C   1 
ATOM   1685 O  O   . GLU A 1 208 ? -4.19547  24.48919 3.54052   1.000 22.24711 ? 208  GLU A O   1 
ATOM   1686 C  CB  . GLU A 1 208 ? -3.50225  21.37458 2.97295   1.000 16.39252 ? 208  GLU A CB  1 
ATOM   1687 C  CG  . GLU A 1 208 ? -3.51295  20.10936 2.09525   1.000 15.40740 ? 208  GLU A CG  1 
ATOM   1688 C  CD  . GLU A 1 208 ? -4.60406  19.09592 2.48001   1.000 14.13463 ? 208  GLU A CD  1 
ATOM   1689 O  OE1 . GLU A 1 208 ? -5.32914  19.31345 3.46495   1.000 17.56452 ? 208  GLU A OE1 1 
ATOM   1690 O  OE2 . GLU A 1 208 ? -4.74472  18.06723 1.79396   1.000 16.59186 ? 208  GLU A OE2 1 
ATOM   1691 N  N   . PRO A 1 209 ? -5.24541  23.20314 5.05132   1.000 14.17820 ? 209  PRO A N   1 
ATOM   1692 C  CA  . PRO A 1 209 ? -5.80554  21.96668 5.62193   1.000 16.00441 ? 209  PRO A CA  1 
ATOM   1693 C  C   . PRO A 1 209 ? -7.28810  21.67974 5.28728   1.000 18.98447 ? 209  PRO A C   1 
ATOM   1694 O  O   . PRO A 1 209 ? -7.82274  20.65686 5.73191   1.000 18.36953 ? 209  PRO A O   1 
ATOM   1695 C  CB  . PRO A 1 209 ? -5.63150  22.18990 7.12471   1.000 16.67813 ? 209  PRO A CB  1 
ATOM   1696 C  CG  . PRO A 1 209 ? -5.79084  23.67686 7.28566   1.000 18.34668 ? 209  PRO A CG  1 
ATOM   1697 C  CD  . PRO A 1 209 ? -5.15568  24.28147 6.04923   1.000 16.37713 ? 209  PRO A CD  1 
ATOM   1698 N  N   . LYS A 1 210 ? -7.93450  22.55398 4.50823   1.000 17.96751 ? 210  LYS A N   1 
ATOM   1699 C  CA  . LYS A 1 210 ? -9.34840  22.35071 4.18580   1.000 18.53171 ? 210  LYS A CA  1 
ATOM   1700 C  C   . LYS A 1 210 ? -9.56759  21.06621 3.38497   1.000 14.99833 ? 210  LYS A C   1 
ATOM   1701 O  O   . LYS A 1 210 ? -10.50030 20.30605 3.66251   1.000 12.83121 ? 210  LYS A O   1 
ATOM   1702 C  CB  . LYS A 1 210 ? -9.88994  23.56850 3.42708   1.000 15.11225 ? 210  LYS A CB  1 
ATOM   1703 C  CG  . LYS A 1 210 ? -11.36547 23.47050 3.05707   1.000 15.83093 ? 210  LYS A CG  1 
ATOM   1704 C  CD  . LYS A 1 210 ? -11.80823 24.69060 2.25289   1.000 16.80196 ? 210  LYS A CD  1 
ATOM   1705 C  CE  . LYS A 1 210 ? -12.75342 25.57549 3.04425   1.000 15.26181 ? 210  LYS A CE  1 
ATOM   1706 N  NZ  . LYS A 1 210 ? -13.36993 26.64094 2.20638   1.000 13.81119 ? 210  LYS A NZ  1 
ATOM   1707 N  N   . ARG A 1 211 ? -8.69483  20.78749 2.41525   1.000 12.64427 ? 211  ARG A N   1 
ATOM   1708 C  CA  . ARG A 1 211 ? -8.89557  19.64152 1.53218   1.000 14.82748 ? 211  ARG A CA  1 
ATOM   1709 C  C   . ARG A 1 211 ? -9.00514  18.33135 2.31171   1.000 18.17314 ? 211  ARG A C   1 
ATOM   1710 O  O   . ARG A 1 211 ? -9.96182  17.56870 2.13860   1.000 15.86022 ? 211  ARG A O   1 
ATOM   1711 C  CB  . ARG A 1 211 ? -7.75294  19.55701 0.51228   1.000 13.06918 ? 211  ARG A CB  1 
ATOM   1712 C  CG  . ARG A 1 211 ? -7.79415  18.28116 -0.31909  1.000 13.48624 ? 211  ARG A CG  1 
ATOM   1713 C  CD  . ARG A 1 211 ? -6.83490  18.32112 -1.48907  1.000 15.34350 ? 211  ARG A CD  1 
ATOM   1714 N  NE  . ARG A 1 211 ? -5.42828  18.39860 -1.07564  1.000 17.84626 ? 211  ARG A NE  1 
ATOM   1715 C  CZ  . ARG A 1 211 ? -4.44621  18.76009 -1.89598  1.000 18.87657 ? 211  ARG A CZ  1 
ATOM   1716 N  NH1 . ARG A 1 211 ? -4.74011  19.08339 -3.15559  1.000 14.39471 ? 211  ARG A NH1 1 
ATOM   1717 N  NH2 . ARG A 1 211 ? -3.18062  18.80499 -1.46895  1.000 14.25311 ? 211  ARG A NH2 1 
ATOM   1718 N  N   . THR A 1 212 ? -8.01789  18.03525 3.15673   1.000 16.52855 ? 212  THR A N   1 
ATOM   1719 C  CA  . THR A 1 212 ? -8.04042  16.76987 3.87842   1.000 15.24994 ? 212  THR A CA  1 
ATOM   1720 C  C   . THR A 1 212 ? -9.11932  16.76006 4.95548   1.000 14.61450 ? 212  THR A C   1 
ATOM   1721 O  O   . THR A 1 212 ? -9.68333  15.70159 5.25320   1.000 16.86512 ? 212  THR A O   1 
ATOM   1722 C  CB  . THR A 1 212 ? -6.65265  16.49235 4.46381   1.000 20.83004 ? 212  THR A CB  1 
ATOM   1723 O  OG1 . THR A 1 212 ? -5.74070  16.26565 3.38305   1.000 19.43570 ? 212  THR A OG1 1 
ATOM   1724 C  CG2 . THR A 1 212 ? -6.65849  15.24316 5.37171   1.000 16.19394 ? 212  THR A CG2 1 
ATOM   1725 N  N   . ALA A 1 213 ? -9.43360  17.92307 5.53211   1.000 17.31010 ? 213  ALA A N   1 
ATOM   1726 C  CA  . ALA A 1 213 ? -10.56007 18.01211 6.45994   1.000 18.55144 ? 213  ALA A CA  1 
ATOM   1727 C  C   . ALA A 1 213 ? -11.88199 17.69698 5.75781   1.000 17.94416 ? 213  ALA A C   1 
ATOM   1728 O  O   . ALA A 1 213 ? -12.73461 16.98209 6.30490   1.000 13.61931 ? 213  ALA A O   1 
ATOM   1729 C  CB  . ALA A 1 213 ? -10.60838 19.40259 7.09035   1.000 13.77766 ? 213  ALA A CB  1 
ATOM   1730 N  N   . LEU A 1 214 ? -12.06866 18.22636 4.54666   1.000 16.00338 ? 214  LEU A N   1 
ATOM   1731 C  CA  . LEU A 1 214 ? -13.22488 17.85988 3.73139   1.000 13.72438 ? 214  LEU A CA  1 
ATOM   1732 C  C   . LEU A 1 214 ? -13.24135 16.36660 3.44696   1.000 13.21850 ? 214  LEU A C   1 
ATOM   1733 O  O   . LEU A 1 214 ? -14.26798 15.69326 3.61152   1.000 14.66934 ? 214  LEU A O   1 
ATOM   1734 C  CB  . LEU A 1 214 ? -13.19412 18.63685 2.41731   1.000 15.09633 ? 214  LEU A CB  1 
ATOM   1735 C  CG  . LEU A 1 214 ? -13.93612 19.95965 2.42710   1.000 22.12781 ? 214  LEU A CG  1 
ATOM   1736 C  CD1 . LEU A 1 214 ? -13.49215 20.83575 1.25315   1.000 18.43986 ? 214  LEU A CD1 1 
ATOM   1737 C  CD2 . LEU A 1 214 ? -15.43917 19.68051 2.39591   1.000 23.07349 ? 214  LEU A CD2 1 
ATOM   1738 N  N   . TYR A 1 215 ? -12.10359 15.83467 3.00526   1.000 13.46525 ? 215  TYR A N   1 
ATOM   1739 C  CA  . TYR A 1 215 ? -11.98442 14.40004 2.76114   1.000 14.91875 ? 215  TYR A CA  1 
ATOM   1740 C  C   . TYR A 1 215 ? -12.35799 13.58672 3.99771   1.000 15.61887 ? 215  TYR A C   1 
ATOM   1741 O  O   . TYR A 1 215 ? -13.14373 12.63533 3.91487   1.000 14.77189 ? 215  TYR A O   1 
ATOM   1742 C  CB  . TYR A 1 215 ? -10.55745 14.09145 2.31883   1.000 16.24419 ? 215  TYR A CB  1 
ATOM   1743 C  CG  . TYR A 1 215 ? -10.24973 12.63281 2.10630   1.000 19.04312 ? 215  TYR A CG  1 
ATOM   1744 C  CD1 . TYR A 1 215 ? -10.38868 12.05641 0.85289   1.000 19.89767 ? 215  TYR A CD1 1 
ATOM   1745 C  CD2 . TYR A 1 215 ? -9.77371  11.84085 3.14758   1.000 20.98899 ? 215  TYR A CD2 1 
ATOM   1746 C  CE1 . TYR A 1 215 ? -10.08589 10.72987 0.64337   1.000 21.86733 ? 215  TYR A CE1 1 
ATOM   1747 C  CE2 . TYR A 1 215 ? -9.46863  10.50828 2.94571   1.000 21.23647 ? 215  TYR A CE2 1 
ATOM   1748 C  CZ  . TYR A 1 215 ? -9.62880  9.96328  1.69199   1.000 25.82114 ? 215  TYR A CZ  1 
ATOM   1749 O  OH  . TYR A 1 215 ? -9.32947  8.64464  1.47757   1.000 29.26785 ? 215  TYR A OH  1 
ATOM   1750 N  N   . ASN A 1 216 ? -11.77752 13.92814 5.15153   1.000 16.46096 ? 216  ASN A N   1 
ATOM   1751 C  CA  . ASN A 1 216 ? -12.04116 13.16136 6.36603   1.000 16.26039 ? 216  ASN A CA  1 
ATOM   1752 C  C   . ASN A 1 216 ? -13.50465 13.26423 6.78039   1.000 17.03172 ? 216  ASN A C   1 
ATOM   1753 O  O   . ASN A 1 216 ? -14.11582 12.26580 7.17799   1.000 17.13691 ? 216  ASN A O   1 
ATOM   1754 C  CB  . ASN A 1 216 ? -11.14047 13.64551 7.50232   1.000 17.88534 ? 216  ASN A CB  1 
ATOM   1755 C  CG  . ASN A 1 216 ? -9.67999  13.26783 7.30164   1.000 19.89171 ? 216  ASN A CG  1 
ATOM   1756 O  OD1 . ASN A 1 216 ? -9.35368  12.35551 6.54217   1.000 21.60261 ? 216  ASN A OD1 1 
ATOM   1757 N  ND2 . ASN A 1 216 ? -8.79556  13.96800 8.00119   1.000 18.69655 ? 216  ASN A ND2 1 
ATOM   1758 N  N   . LEU A 1 217 ? -14.08401 14.46429 6.68785   1.000 17.53555 ? 217  LEU A N   1 
ATOM   1759 C  CA  . LEU A 1 217 ? -15.48412 14.64934 7.06025   1.000 17.28151 ? 217  LEU A CA  1 
ATOM   1760 C  C   . LEU A 1 217 ? -16.40382 13.78076 6.20817   1.000 16.38940 ? 217  LEU A C   1 
ATOM   1761 O  O   . LEU A 1 217 ? -17.24047 13.03683 6.73403   1.000 18.45490 ? 217  LEU A O   1 
ATOM   1762 C  CB  . LEU A 1 217 ? -15.86336 16.12530 6.94170   1.000 16.53578 ? 217  LEU A CB  1 
ATOM   1763 C  CG  . LEU A 1 217 ? -17.34960 16.44065 7.11459   1.000 19.17090 ? 217  LEU A CG  1 
ATOM   1764 C  CD1 . LEU A 1 217 ? -17.81295 16.11783 8.53995   1.000 17.61779 ? 217  LEU A CD1 1 
ATOM   1765 C  CD2 . LEU A 1 217 ? -17.62023 17.90009 6.76760   1.000 16.19252 ? 217  LEU A CD2 1 
ATOM   1766 N  N   . VAL A 1 218 ? -16.24115 13.83227 4.88624   1.000 15.00949 ? 218  VAL A N   1 
ATOM   1767 C  CA  . VAL A 1 218 ? -17.12152 13.05975 4.01216   1.000 16.72619 ? 218  VAL A CA  1 
ATOM   1768 C  C   . VAL A 1 218 ? -16.89531 11.56413 4.20303   1.000 19.90333 ? 218  VAL A C   1 
ATOM   1769 O  O   . VAL A 1 218 ? -17.84343 10.77050 4.17768   1.000 15.87761 ? 218  VAL A O   1 
ATOM   1770 C  CB  . VAL A 1 218 ? -16.91897 13.47855 2.54366   1.000 19.55407 ? 218  VAL A CB  1 
ATOM   1771 C  CG1 . VAL A 1 218 ? -17.63029 12.51071 1.62388   1.000 19.64171 ? 218  VAL A CG1 1 
ATOM   1772 C  CG2 . VAL A 1 218 ? -17.41961 14.90142 2.32565   1.000 15.31336 ? 218  VAL A CG2 1 
ATOM   1773 N  N   . LYS A 1 219 ? -15.63555 11.15014 4.36774   1.000 19.86835 ? 219  LYS A N   1 
ATOM   1774 C  CA  . LYS A 1 219 ? -15.34788 9.73341  4.58643   1.000 20.19766 ? 219  LYS A CA  1 
ATOM   1775 C  C   . LYS A 1 219 ? -16.04678 9.23253  5.84655   1.000 19.80951 ? 219  LYS A C   1 
ATOM   1776 O  O   . LYS A 1 219 ? -16.63674 8.14733  5.85489   1.000 20.89304 ? 219  LYS A O   1 
ATOM   1777 C  CB  . LYS A 1 219 ? -13.83026 9.52801  4.67222   1.000 19.74561 ? 219  LYS A CB  1 
ATOM   1778 C  CG  . LYS A 1 219 ? -13.35875 8.09661  4.89839   1.000 23.99858 ? 219  LYS A CG  1 
ATOM   1779 C  CD  . LYS A 1 219 ? -11.82966 8.02120  4.86196   1.000 25.81751 ? 219  LYS A CD  1 
ATOM   1780 C  CE  . LYS A 1 219 ? -11.31905 6.59888  5.08318   1.000 32.82676 ? 219  LYS A CE  1 
ATOM   1781 N  NZ  . LYS A 1 219 ? -11.77408 6.05753  6.40153   1.000 37.55736 ? 219  LYS A NZ  1 
ATOM   1782 N  N   . GLN A 1 220 ? -16.00933 10.03470 6.90820   1.000 20.43656 ? 220  GLN A N   1 
ATOM   1783 C  CA  . GLN A 1 220 ? -16.65193 9.67242  8.16501   1.000 24.58864 ? 220  GLN A CA  1 
ATOM   1784 C  C   . GLN A 1 220 ? -18.16934 9.62499  8.01306   1.000 24.56881 ? 220  GLN A C   1 
ATOM   1785 O  O   . GLN A 1 220 ? -18.81562 8.65232  8.42515   1.000 23.07162 ? 220  GLN A O   1 
ATOM   1786 C  CB  . GLN A 1 220 ? -16.22226 10.67281 9.24454   1.000 24.54250 ? 220  GLN A CB  1 
ATOM   1787 C  CG  . GLN A 1 220 ? -16.95453 10.59791 10.57506  1.000 36.26616 ? 220  GLN A CG  1 
ATOM   1788 C  CD  . GLN A 1 220 ? -16.40953 11.60727 11.58096  1.000 48.24457 ? 220  GLN A CD  1 
ATOM   1789 O  OE1 . GLN A 1 220 ? -17.14012 12.47032 12.08594  1.000 49.66940 ? 220  GLN A OE1 1 
ATOM   1790 N  NE2 . GLN A 1 220 ? -15.11134 11.51666 11.85712  1.000 50.70403 ? 220  GLN A NE2 1 
ATOM   1791 N  N   . LEU A 1 221 ? -18.76333 10.65932 7.41270   1.000 20.84300 ? 221  LEU A N   1 
ATOM   1792 C  CA  . LEU A 1 221 ? -20.21459 10.67000 7.25048   1.000 18.34223 ? 221  LEU A CA  1 
ATOM   1793 C  C   . LEU A 1 221 ? -20.69455 9.46802  6.44630   1.000 22.36694 ? 221  LEU A C   1 
ATOM   1794 O  O   . LEU A 1 221 ? -21.69686 8.83655  6.80072   1.000 21.40708 ? 221  LEU A O   1 
ATOM   1795 C  CB  . LEU A 1 221 ? -20.66773 11.98035 6.60192   1.000 16.08587 ? 221  LEU A CB  1 
ATOM   1796 C  CG  . LEU A 1 221 ? -20.31992 13.19124 7.47568   1.000 21.71562 ? 221  LEU A CG  1 
ATOM   1797 C  CD1 . LEU A 1 221 ? -20.78779 14.48335 6.85746   1.000 21.16949 ? 221  LEU A CD1 1 
ATOM   1798 C  CD2 . LEU A 1 221 ? -20.89285 13.02299 8.88118   1.000 24.44835 ? 221  LEU A CD2 1 
ATOM   1799 N  N   . LYS A 1 222 ? -19.97990 9.12260  5.37078   1.000 21.48909 ? 222  LYS A N   1 
ATOM   1800 C  CA  . LYS A 1 222 ? -20.40067 7.99233  4.54570   1.000 21.85118 ? 222  LYS A CA  1 
ATOM   1801 C  C   . LYS A 1 222 ? -20.27282 6.67557  5.29894   1.000 29.60885 ? 222  LYS A C   1 
ATOM   1802 O  O   . LYS A 1 222 ? -21.09482 5.76968  5.11663   1.000 29.17839 ? 222  LYS A O   1 
ATOM   1803 C  CB  . LYS A 1 222 ? -19.58545 7.94612  3.25515   1.000 23.02601 ? 222  LYS A CB  1 
ATOM   1804 C  CG  . LYS A 1 222 ? -19.91550 9.06430  2.27960   1.000 23.00373 ? 222  LYS A CG  1 
ATOM   1805 C  CD  . LYS A 1 222 ? -19.24075 8.82139  0.95394   1.000 27.01416 ? 222  LYS A CD  1 
ATOM   1806 C  CE  . LYS A 1 222 ? -20.01506 7.81905  0.12711   1.000 30.36815 ? 222  LYS A CE  1 
ATOM   1807 N  NZ  . LYS A 1 222 ? -19.09995 7.19908  -0.85805  1.000 31.85510 ? 222  LYS A NZ  1 
ATOM   1808 N  N   . GLU A 1 223 ? -19.23991 6.54430  6.13928   1.000 27.02338 ? 223  GLU A N   1 
ATOM   1809 C  CA  . GLU A 1 223 ? -19.12995 5.35650  6.97982   1.000 27.52455 ? 223  GLU A CA  1 
ATOM   1810 C  C   . GLU A 1 223 ? -20.29958 5.24353  7.94466   1.000 23.58504 ? 223  GLU A C   1 
ATOM   1811 O  O   . GLU A 1 223 ? -20.69538 4.13009  8.30668   1.000 25.35507 ? 223  GLU A O   1 
ATOM   1812 C  CB  . GLU A 1 223 ? -17.81064 5.37467  7.75106   1.000 25.35177 ? 223  GLU A CB  1 
ATOM   1813 C  CG  . GLU A 1 223 ? -16.63269 4.93658  6.90888   1.000 29.25033 ? 223  GLU A CG  1 
ATOM   1814 C  CD  . GLU A 1 223 ? -15.30637 5.28386  7.54545   1.000 32.22418 ? 223  GLU A CD  1 
ATOM   1815 O  OE1 . GLU A 1 223 ? -15.30882 5.90201  8.63656   1.000 33.85357 ? 223  GLU A OE1 1 
ATOM   1816 O  OE2 . GLU A 1 223 ? -14.26335 4.94738  6.94564   1.000 30.83585 ? 223  GLU A OE2 1 
ATOM   1817 N  N   . GLU A 1 224 ? -20.85406 6.37266  8.38153   1.000 27.60223 ? 224  GLU A N   1 
ATOM   1818 C  CA  . GLU A 1 224 ? -22.02980 6.38302  9.24348   1.000 23.26644 ? 224  GLU A CA  1 
ATOM   1819 C  C   . GLU A 1 224 ? -23.33478 6.27768  8.46567   1.000 23.49002 ? 224  GLU A C   1 
ATOM   1820 O  O   . GLU A 1 224 ? -24.40400 6.41903  9.06195   1.000 29.53022 ? 224  GLU A O   1 
ATOM   1821 C  CB  . GLU A 1 224 ? -22.03824 7.64155  10.10751  1.000 22.99699 ? 224  GLU A CB  1 
ATOM   1822 C  CG  . GLU A 1 224 ? -20.81188 7.75168  10.98818  1.000 28.05493 ? 224  GLU A CG  1 
ATOM   1823 C  CD  . GLU A 1 224 ? -20.77020 9.03882  11.77497  1.000 29.92946 ? 224  GLU A CD  1 
ATOM   1824 O  OE1 . GLU A 1 224 ? -21.75348 9.80709  11.71793  1.000 37.22194 ? 224  GLU A OE1 1 
ATOM   1825 O  OE2 . GLU A 1 224 ? -19.75386 9.27834  12.45602  1.000 33.44206 ? 224  GLU A OE2 1 
ATOM   1826 N  N   . GLY A 1 225 ? -23.27522 6.03272  7.15619   1.000 22.82713 ? 225  GLY A N   1 
ATOM   1827 C  CA  . GLY A 1 225 ? -24.46571 5.86212  6.34922   1.000 26.72235 ? 225  GLY A CA  1 
ATOM   1828 C  C   . GLY A 1 225 ? -25.08847 7.13318  5.80346   1.000 27.55253 ? 225  GLY A C   1 
ATOM   1829 O  O   . GLY A 1 225 ? -26.14357 7.05608  5.16488   1.000 32.09759 ? 225  GLY A O   1 
ATOM   1830 N  N   . VAL A 1 226 ? -24.48578 8.29301  6.02980   1.000 24.19844 ? 226  VAL A N   1 
ATOM   1831 C  CA  . VAL A 1 226 ? -25.04458 9.53734  5.48370   1.000 17.24445 ? 226  VAL A CA  1 
ATOM   1832 C  C   . VAL A 1 226 ? -24.93946 9.50033  3.95961   1.000 19.63386 ? 226  VAL A C   1 
ATOM   1833 O  O   . VAL A 1 226 ? -23.86211 9.18921  3.42561   1.000 19.36275 ? 226  VAL A O   1 
ATOM   1834 C  CB  . VAL A 1 226 ? -24.31356 10.74673 6.06597   1.000 20.44386 ? 226  VAL A CB  1 
ATOM   1835 C  CG1 . VAL A 1 226 ? -24.90745 12.06369 5.54705   1.000 15.05392 ? 226  VAL A CG1 1 
ATOM   1836 C  CG2 . VAL A 1 226 ? -24.36305 10.70381 7.58611   1.000 18.10166 ? 226  VAL A CG2 1 
ATOM   1837 N  N   . PRO A 1 227 ? -26.02019 9.77026  3.21444   1.000 18.69653 ? 227  PRO A N   1 
ATOM   1838 C  CA  . PRO A 1 227 ? -25.94335 9.69572  1.74440   1.000 20.35805 ? 227  PRO A CA  1 
ATOM   1839 C  C   . PRO A 1 227 ? -25.25954 10.90369 1.16088   1.000 17.16446 ? 227  PRO A C   1 
ATOM   1840 O  O   . PRO A 1 227 ? -25.80943 12.02871 1.17303   1.000 20.97658 ? 227  PRO A O   1 
ATOM   1841 C  CB  . PRO A 1 227 ? -27.42054 9.59422  1.33061   1.000 16.71682 ? 227  PRO A CB  1 
ATOM   1842 C  CG  . PRO A 1 227 ? -28.17165 10.29698 2.41715   1.000 16.63535 ? 227  PRO A CG  1 
ATOM   1843 C  CD  . PRO A 1 227 ? -27.37758 10.08541 3.69600   1.000 16.71282 ? 227  PRO A CD  1 
ATOM   1844 N  N   . ILE A 1 228 ? -24.04578 10.73486 0.64280   1.000 15.74426 ? 228  ILE A N   1 
ATOM   1845 C  CA  . ILE A 1 228 ? -23.30102 11.79450 -0.03232  1.000 17.74491 ? 228  ILE A CA  1 
ATOM   1846 C  C   . ILE A 1 228 ? -22.76820 11.22470 -1.33622  1.000 17.73729 ? 228  ILE A C   1 
ATOM   1847 O  O   . ILE A 1 228 ? -21.95070 10.29439 -1.31858  1.000 14.35226 ? 228  ILE A O   1 
ATOM   1848 C  CB  . ILE A 1 228 ? -22.14458 12.35356 0.82044   1.000 15.18914 ? 228  ILE A CB  1 
ATOM   1849 C  CG1 . ILE A 1 228 ? -22.64816 12.76933 2.20424   1.000 17.13173 ? 228  ILE A CG1 1 
ATOM   1850 C  CG2 . ILE A 1 228 ? -21.49666 13.56836 0.11577   1.000 12.81711 ? 228  ILE A CG2 1 
ATOM   1851 C  CD1 . ILE A 1 228 ? -21.56252 13.28290 3.14233   1.000 17.98539 ? 228  ILE A CD1 1 
ATOM   1852 N  N   . ASP A 1 229 ? -23.21077 11.79035 -2.46334  1.000 12.37719 ? 229  ASP A N   1 
ATOM   1853 C  CA  . ASP A 1 229 ? -22.80954 11.27675 -3.76793  1.000 14.67693 ? 229  ASP A CA  1 
ATOM   1854 C  C   . ASP A 1 229 ? -21.60575 11.99559 -4.36207  1.000 13.33472 ? 229  ASP A C   1 
ATOM   1855 O  O   . ASP A 1 229 ? -20.89961 11.41537 -5.19384  1.000 12.16567 ? 229  ASP A O   1 
ATOM   1856 C  CB  . ASP A 1 229 ? -23.98934 11.36390 -4.73332  1.000 13.00027 ? 229  ASP A CB  1 
ATOM   1857 C  CG  . ASP A 1 229 ? -25.17792 10.59556 -4.22674  1.000 17.05606 ? 229  ASP A CG  1 
ATOM   1858 O  OD1 . ASP A 1 229 ? -24.99492 9.38912  -3.95357  1.000 14.53136 ? 229  ASP A OD1 1 
ATOM   1859 O  OD2 . ASP A 1 229 ? -26.26566 11.19510 -4.05758  1.000 15.36542 ? 229  ASP A OD2 1 
ATOM   1860 N  N   . GLY A 1 230 ? -21.34362 13.23745 -3.97595  1.000 9.78750  ? 230  GLY A N   1 
ATOM   1861 C  CA  . GLY A 1 230 ? -20.23874 13.89962 -4.64206  1.000 9.78657  ? 230  GLY A CA  1 
ATOM   1862 C  C   . GLY A 1 230 ? -19.77313 15.14042 -3.91762  1.000 10.97574 ? 230  GLY A C   1 
ATOM   1863 O  O   . GLY A 1 230 ? -20.31126 15.52662 -2.87451  1.000 10.27351 ? 230  GLY A O   1 
ATOM   1864 N  N   . ILE A 1 231 ? -18.74442 15.75920 -4.49822  1.000 7.53201  ? 231  ILE A N   1 
ATOM   1865 C  CA  . ILE A 1 231 ? -18.19113 17.02233 -4.02575  1.000 7.93745  ? 231  ILE A CA  1 
ATOM   1866 C  C   . ILE A 1 231 ? -18.41871 18.07247 -5.10010  1.000 9.02132  ? 231  ILE A C   1 
ATOM   1867 O  O   . ILE A 1 231 ? -18.09375 17.84865 -6.27646  1.000 10.24495 ? 231  ILE A O   1 
ATOM   1868 C  CB  . ILE A 1 231 ? -16.68844 16.91430 -3.71406  1.000 11.67114 ? 231  ILE A CB  1 
ATOM   1869 C  CG1 . ILE A 1 231 ? -16.41402 15.82077 -2.67403  1.000 12.54775 ? 231  ILE A CG1 1 
ATOM   1870 C  CG2 . ILE A 1 231 ? -16.14321 18.29113 -3.27724  1.000 8.52916  ? 231  ILE A CG2 1 
ATOM   1871 C  CD1 . ILE A 1 231 ? -16.96006 16.13094 -1.27457  1.000 13.25006 ? 231  ILE A CD1 1 
ATOM   1872 N  N   . GLY A 1 232 ? -18.93707 19.23464 -4.70226  1.000 8.11238  ? 232  GLY A N   1 
ATOM   1873 C  CA  . GLY A 1 232 ? -19.02675 20.37810 -5.58317  1.000 10.81664 ? 232  GLY A CA  1 
ATOM   1874 C  C   . GLY A 1 232 ? -17.87851 21.30646 -5.31897  1.000 10.78541 ? 232  GLY A C   1 
ATOM   1875 O  O   . GLY A 1 232 ? -17.76666 21.88165 -4.22681  1.000 8.21627  ? 232  GLY A O   1 
ATOM   1876 N  N   . HIS A 1 233 ? -16.98297 21.46101 -6.30712  1.000 8.87898  ? 233  HIS A N   1 
ATOM   1877 C  CA  . HIS A 1 233 ? -15.81823 22.33153 -6.20296  1.000 8.83707  ? 233  HIS A CA  1 
ATOM   1878 C  C   . HIS A 1 233 ? -16.16678 23.68425 -6.81278  1.000 11.72579 ? 233  HIS A C   1 
ATOM   1879 O  O   . HIS A 1 233 ? -16.27239 23.80660 -8.03593  1.000 11.11507 ? 233  HIS A O   1 
ATOM   1880 C  CB  . HIS A 1 233 ? -14.59949 21.73458 -6.90835  1.000 11.39771 ? 233  HIS A CB  1 
ATOM   1881 C  CG  . HIS A 1 233 ? -14.32343 20.30362 -6.54566  1.000 10.87324 ? 233  HIS A CG  1 
ATOM   1882 N  ND1 . HIS A 1 233 ? -13.37544 19.94504 -5.61261  1.000 10.67544 ? 233  HIS A ND1 1 
ATOM   1883 C  CD2 . HIS A 1 233 ? -14.86717 19.14718 -6.99368  1.000 9.88880  ? 233  HIS A CD2 1 
ATOM   1884 C  CE1 . HIS A 1 233 ? -13.35176 18.62977 -5.49484  1.000 11.81706 ? 233  HIS A CE1 1 
ATOM   1885 N  NE2 . HIS A 1 233 ? -14.23844 18.12006 -6.33040  1.000 11.86522 ? 233  HIS A NE2 1 
ATOM   1886 N  N   . GLN A 1 234 ? -16.31203 24.70646 -5.96714  1.000 8.68218  ? 234  GLN A N   1 
ATOM   1887 C  CA  . GLN A 1 234 ? -16.67119 26.02254 -6.48224  1.000 9.61256  ? 234  GLN A CA  1 
ATOM   1888 C  C   . GLN A 1 234 ? -15.67264 26.50446 -7.52888  1.000 11.26732 ? 234  GLN A C   1 
ATOM   1889 O  O   . GLN A 1 234 ? -16.07436 27.09479 -8.53199  1.000 8.71261  ? 234  GLN A O   1 
ATOM   1890 C  CB  . GLN A 1 234 ? -16.79457 27.02834 -5.34025  1.000 8.66142  ? 234  GLN A CB  1 
ATOM   1891 C  CG  . GLN A 1 234 ? -18.09435 26.86569 -4.54155  1.000 6.90680  ? 234  GLN A CG  1 
ATOM   1892 C  CD  . GLN A 1 234 ? -18.19304 27.89513 -3.43041  1.000 12.64708 ? 234  GLN A CD  1 
ATOM   1893 O  OE1 . GLN A 1 234 ? -17.73136 29.02053 -3.58430  1.000 8.54850  ? 234  GLN A OE1 1 
ATOM   1894 N  NE2 . GLN A 1 234 ? -18.78291 27.51268 -2.30753  1.000 9.47672  ? 234  GLN A NE2 1 
ATOM   1895 N  N   . SER A 1 235 ? -14.37519 26.22739 -7.33160  1.000 7.68714  ? 235  SER A N   1 
ATOM   1896 C  CA  . SER A 1 235 ? -13.32947 26.60843 -8.29157  1.000 12.16453 ? 235  SER A CA  1 
ATOM   1897 C  C   . SER A 1 235 ? -13.34860 28.10989 -8.60092  1.000 9.26663  ? 235  SER A C   1 
ATOM   1898 O  O   . SER A 1 235 ? -13.35671 28.53101 -9.75569  1.000 8.24149  ? 235  SER A O   1 
ATOM   1899 C  CB  . SER A 1 235 ? -13.43176 25.79579 -9.59015  1.000 11.41552 ? 235  SER A CB  1 
ATOM   1900 O  OG  . SER A 1 235 ? -13.68163 24.42561 -9.32402  1.000 14.39918 ? 235  SER A OG  1 
ATOM   1901 N  N   . HIS A 1 236 ? -13.34476 28.91927 -7.54580  1.000 7.72448  ? 236  HIS A N   1 
ATOM   1902 C  CA  . HIS A 1 236 ? -13.13027 30.35678 -7.70356  1.000 6.96123  ? 236  HIS A CA  1 
ATOM   1903 C  C   . HIS A 1 236 ? -11.61839 30.54428 -7.70397  1.000 11.23175 ? 236  HIS A C   1 
ATOM   1904 O  O   . HIS A 1 236 ? -10.97868 30.62912 -6.65244  1.000 8.48256  ? 236  HIS A O   1 
ATOM   1905 C  CB  . HIS A 1 236 ? -13.82137 31.13888 -6.58968  1.000 8.57927  ? 236  HIS A CB  1 
ATOM   1906 C  CG  . HIS A 1 236 ? -15.30998 31.05292 -6.64495  1.000 10.17929 ? 236  HIS A CG  1 
ATOM   1907 N  ND1 . HIS A 1 236 ? -16.02866 31.37829 -7.77566  1.000 10.69688 ? 236  HIS A ND1 1 
ATOM   1908 C  CD2 . HIS A 1 236 ? -16.21678 30.66875 -5.71550  1.000 8.37976  ? 236  HIS A CD2 1 
ATOM   1909 C  CE1 . HIS A 1 236 ? -17.31705 31.19097 -7.54166  1.000 8.33180  ? 236  HIS A CE1 1 
ATOM   1910 N  NE2 . HIS A 1 236 ? -17.45774 30.77399 -6.29479  1.000 11.39767 ? 236  HIS A NE2 1 
ATOM   1911 N  N   . ILE A 1 237 ? -11.03205 30.55559 -8.90000  1.000 8.80836  ? 237  ILE A N   1 
ATOM   1912 C  CA  . ILE A 1 237 ? -9.58205  30.42840 -9.01596  1.000 10.17430 ? 237  ILE A CA  1 
ATOM   1913 C  C   . ILE A 1 237 ? -8.96673  31.63342 -9.70930  1.000 10.17305 ? 237  ILE A C   1 
ATOM   1914 O  O   . ILE A 1 237 ? -9.66720  32.55028 -10.15757 1.000 8.72201  ? 237  ILE A O   1 
ATOM   1915 C  CB  . ILE A 1 237 ? -9.20220  29.13270 -9.75885  1.000 11.88001 ? 237  ILE A CB  1 
ATOM   1916 C  CG1 . ILE A 1 237 ? -9.69722  29.17141 -11.21572 1.000 8.39115  ? 237  ILE A CG1 1 
ATOM   1917 C  CG2 . ILE A 1 237 ? -9.76977  27.91332 -9.02541  1.000 9.71601  ? 237  ILE A CG2 1 
ATOM   1918 C  CD1 . ILE A 1 237 ? -9.40604  27.89055 -11.99927 1.000 10.12759 ? 237  ILE A CD1 1 
ATOM   1919 N  N   . GLN A 1 238 ? -7.64451  31.62540 -9.79585  1.000 8.68296  ? 238  GLN A N   1 
ATOM   1920 C  CA  . GLN A 1 238 ? -6.85576  32.67939 -10.39324 1.000 9.56676  ? 238  GLN A CA  1 
ATOM   1921 C  C   . GLN A 1 238 ? -6.14092  32.11967 -11.61322 1.000 11.55994 ? 238  GLN A C   1 
ATOM   1922 O  O   . GLN A 1 238 ? -6.23344  30.92474 -11.93193 1.000 9.66749  ? 238  GLN A O   1 
ATOM   1923 C  CB  . GLN A 1 238 ? -5.86312  33.25202 -9.37235  1.000 10.40516 ? 238  GLN A CB  1 
ATOM   1924 C  CG  . GLN A 1 238 ? -6.53329  33.83671 -8.11089  1.000 10.56486 ? 238  GLN A CG  1 
ATOM   1925 C  CD  . GLN A 1 238 ? -5.52408  34.11872 -7.00823  1.000 12.94811 ? 238  GLN A CD  1 
ATOM   1926 O  OE1 . GLN A 1 238 ? -4.32248  34.10729 -7.24933  1.000 15.46979 ? 238  GLN A OE1 1 
ATOM   1927 N  NE2 . GLN A 1 238 ? -6.00624  34.36033 -5.80114  1.000 19.00364 ? 238  GLN A NE2 1 
ATOM   1928 N  N   . ILE A 1 239 ? -5.41556  33.00271 -12.29849 1.000 11.57535 ? 239  ILE A N   1 
ATOM   1929 C  CA  . ILE A 1 239 ? -4.66059  32.57395 -13.46929 1.000 12.99248 ? 239  ILE A CA  1 
ATOM   1930 C  C   . ILE A 1 239 ? -3.54552  31.61259 -13.06231 1.000 14.44707 ? 239  ILE A C   1 
ATOM   1931 O  O   . ILE A 1 239 ? -3.24612  30.65073 -13.77855 1.000 13.18679 ? 239  ILE A O   1 
ATOM   1932 C  CB  . ILE A 1 239 ? -4.12765  33.80383 -14.22846 1.000 13.63189 ? 239  ILE A CB  1 
ATOM   1933 C  CG1 . ILE A 1 239 ? -5.30012  34.56195 -14.86754 1.000 8.79330  ? 239  ILE A CG1 1 
ATOM   1934 C  CG2 . ILE A 1 239 ? -3.07305  33.39624 -15.26737 1.000 12.46441 ? 239  ILE A CG2 1 
ATOM   1935 C  CD1 . ILE A 1 239 ? -4.89874  35.81655 -15.64369 1.000 8.36646  ? 239  ILE A CD1 1 
ATOM   1936 N  N   . GLY A 1 240 ? -2.92449  31.84451 -11.90977 1.000 12.98182 ? 240  GLY A N   1 
ATOM   1937 C  CA  . GLY A 1 240 ? -1.84416  30.98221 -11.46965 1.000 17.52166 ? 240  GLY A CA  1 
ATOM   1938 C  C   . GLY A 1 240 ? -2.30166  29.92609 -10.47841 1.000 21.42740 ? 240  GLY A C   1 
ATOM   1939 O  O   . GLY A 1 240 ? -2.03640  28.73371 -10.64905 1.000 27.81426 ? 240  GLY A O   1 
ATOM   1940 N  N   . TRP A 1 241 ? -3.02797  30.34913 -9.46460  1.000 15.40652 ? 241  TRP A N   1 
ATOM   1941 C  CA  . TRP A 1 241 ? -3.36575  29.53551 -8.31236  1.000 14.12579 ? 241  TRP A CA  1 
ATOM   1942 C  C   . TRP A 1 241 ? -4.81985  29.08615 -8.37946  1.000 15.74770 ? 241  TRP A C   1 
ATOM   1943 O  O   . TRP A 1 241 ? -5.68819  29.85435 -8.81067  1.000 13.10274 ? 241  TRP A O   1 
ATOM   1944 C  CB  . TRP A 1 241 ? -3.13031  30.34287 -7.02901  1.000 12.52460 ? 241  TRP A CB  1 
ATOM   1945 C  CG  . TRP A 1 241 ? -3.71267  29.72883 -5.78926  1.000 19.78541 ? 241  TRP A CG  1 
ATOM   1946 C  CD1 . TRP A 1 241 ? -3.04971  28.99123 -4.85145  1.000 19.14210 ? 241  TRP A CD1 1 
ATOM   1947 C  CD2 . TRP A 1 241 ? -5.07493  29.81695 -5.34209  1.000 20.42444 ? 241  TRP A CD2 1 
ATOM   1948 N  NE1 . TRP A 1 241 ? -3.91698  28.60806 -3.85550  1.000 25.56941 ? 241  TRP A NE1 1 
ATOM   1949 C  CE2 . TRP A 1 241 ? -5.16472  29.10276 -4.13513  1.000 25.22800 ? 241  TRP A CE2 1 
ATOM   1950 C  CE3 . TRP A 1 241 ? -6.22671  30.43279 -5.84904  1.000 22.24972 ? 241  TRP A CE3 1 
ATOM   1951 C  CZ2 . TRP A 1 241 ? -6.36243  28.98313 -3.42551  1.000 30.11526 ? 241  TRP A CZ2 1 
ATOM   1952 C  CZ3 . TRP A 1 241 ? -7.41299  30.30672 -5.14767  1.000 23.13086 ? 241  TRP A CZ3 1 
ATOM   1953 C  CH2 . TRP A 1 241 ? -7.47043  29.59215 -3.94906  1.000 28.46937 ? 241  TRP A CH2 1 
ATOM   1954 N  N   . PRO A 1 242 ? -5.13569  27.84834 -7.96838  1.000 17.84950 ? 242  PRO A N   1 
ATOM   1955 C  CA  . PRO A 1 242 ? -4.18531  26.80544 -7.56929  1.000 15.18669 ? 242  PRO A CA  1 
ATOM   1956 C  C   . PRO A 1 242 ? -3.58012  26.10467 -8.78065  1.000 13.77842 ? 242  PRO A C   1 
ATOM   1957 O  O   . PRO A 1 242 ? -4.10579  26.21691 -9.88079  1.000 15.52357 ? 242  PRO A O   1 
ATOM   1958 C  CB  . PRO A 1 242 ? -5.04555  25.84171 -6.74714  1.000 16.71412 ? 242  PRO A CB  1 
ATOM   1959 C  CG  . PRO A 1 242 ? -6.40694  26.00576 -7.28082  1.000 26.98305 ? 242  PRO A CG  1 
ATOM   1960 C  CD  . PRO A 1 242 ? -6.53302  27.43835 -7.74360  1.000 19.08925 ? 242  PRO A CD  1 
ATOM   1961 N  N   . SER A 1 243 ? -2.48244  25.38852 -8.58083  1.000 13.11674 ? 243  SER A N   1 
ATOM   1962 C  CA  . SER A 1 243 ? -1.80806  24.75007 -9.69937  1.000 13.16582 ? 243  SER A CA  1 
ATOM   1963 C  C   . SER A 1 243 ? -2.64678  23.60990 -10.25900 1.000 13.32294 ? 243  SER A C   1 
ATOM   1964 O  O   . SER A 1 243 ? -3.47485  23.01405 -9.56246  1.000 13.19431 ? 243  SER A O   1 
ATOM   1965 C  CB  . SER A 1 243 ? -0.44960  24.21763 -9.26255  1.000 14.97721 ? 243  SER A CB  1 
ATOM   1966 O  OG  . SER A 1 243 ? -0.61686  23.03042 -8.49973  1.000 14.31482 ? 243  SER A OG  1 
ATOM   1967 N  N   . GLU A 1 244 ? -2.42242  23.30169 -11.53726 1.000 15.61999 ? 244  GLU A N   1 
ATOM   1968 C  CA  . GLU A 1 244 ? -3.12754  22.17616 -12.13520 1.000 16.31217 ? 244  GLU A CA  1 
ATOM   1969 C  C   . GLU A 1 244 ? -2.78250  20.87586 -11.41531 1.000 15.59272 ? 244  GLU A C   1 
ATOM   1970 O  O   . GLU A 1 244 ? -3.65839  20.03139 -11.20071 1.000 13.48578 ? 244  GLU A O   1 
ATOM   1971 C  CB  . GLU A 1 244 ? -2.81567  22.09129 -13.62786 1.000 14.93824 ? 244  GLU A CB  1 
ATOM   1972 C  CG  . GLU A 1 244 ? -3.52609  23.15940 -14.45101 1.000 14.75297 ? 244  GLU A CG  1 
ATOM   1973 C  CD  . GLU A 1 244 ? -2.62737  24.35852 -14.76228 1.000 20.91035 ? 244  GLU A CD  1 
ATOM   1974 O  OE1 . GLU A 1 244 ? -1.41659  24.15974 -14.97577 1.000 25.39957 ? 244  GLU A OE1 1 
ATOM   1975 O  OE2 . GLU A 1 244 ? -3.12626  25.50253 -14.80572 1.000 17.95103 ? 244  GLU A OE2 1 
ATOM   1976 N  N   . ALA A 1 245 ? -1.51809  20.71931 -10.99590 1.000 14.46795 ? 245  ALA A N   1 
ATOM   1977 C  CA  . ALA A 1 245 ? -1.13017  19.52954 -10.24767 1.000 15.81554 ? 245  ALA A CA  1 
ATOM   1978 C  C   . ALA A 1 245 ? -1.96160  19.38186 -8.98212  1.000 13.43677 ? 245  ALA A C   1 
ATOM   1979 O  O   . ALA A 1 245 ? -2.35760  18.26929 -8.62314  1.000 11.53489 ? 245  ALA A O   1 
ATOM   1980 C  CB  . ALA A 1 245 ? 0.36392   19.57307 -9.90176  1.000 17.57700 ? 245  ALA A CB  1 
ATOM   1981 N  N   . GLU A 1 246 ? -2.25160  20.49448 -8.29874  1.000 10.21304 ? 246  GLU A N   1 
ATOM   1982 C  CA  . GLU A 1 246 ? -3.01229  20.40049 -7.05419  1.000 12.04516 ? 246  GLU A CA  1 
ATOM   1983 C  C   . GLU A 1 246 ? -4.50619  20.21102 -7.30600  1.000 13.75352 ? 246  GLU A C   1 
ATOM   1984 O  O   . GLU A 1 246 ? -5.18444  19.53988 -6.51794  1.000 10.92681 ? 246  GLU A O   1 
ATOM   1985 C  CB  . GLU A 1 246 ? -2.77389  21.64178 -6.20348  1.000 13.83170 ? 246  GLU A CB  1 
ATOM   1986 C  CG  . GLU A 1 246 ? -1.38260  21.69008 -5.58163  1.000 17.35774 ? 246  GLU A CG  1 
ATOM   1987 C  CD  . GLU A 1 246 ? -1.13877  20.57176 -4.57651  1.000 23.28224 ? 246  GLU A CD  1 
ATOM   1988 O  OE1 . GLU A 1 246 ? -2.11089  20.09466 -3.94046  1.000 19.33247 ? 246  GLU A OE1 1 
ATOM   1989 O  OE2 . GLU A 1 246 ? 0.03681   20.17140 -4.42182  1.000 26.27349 ? 246  GLU A OE2 1 
ATOM   1990 N  N   . ILE A 1 247 ? -5.03250  20.79142 -8.38715  1.000 10.73453 ? 247  ILE A N   1 
ATOM   1991 C  CA  . ILE A 1 247 ? -6.39854  20.47942 -8.80336  1.000 12.16874 ? 247  ILE A CA  1 
ATOM   1992 C  C   . ILE A 1 247 ? -6.54215  18.98555 -9.07515  1.000 13.12994 ? 247  ILE A C   1 
ATOM   1993 O  O   . ILE A 1 247 ? -7.49680  18.33923 -8.62227  1.000 12.49081 ? 247  ILE A O   1 
ATOM   1994 C  CB  . ILE A 1 247 ? -6.78179  21.31842 -10.03273 1.000 10.14535 ? 247  ILE A CB  1 
ATOM   1995 C  CG1 . ILE A 1 247 ? -6.78525  22.80327 -9.65718  1.000 8.76436  ? 247  ILE A CG1 1 
ATOM   1996 C  CG2 . ILE A 1 247 ? -8.14028  20.88977 -10.57067 1.000 9.73240  ? 247  ILE A CG2 1 
ATOM   1997 C  CD1 . ILE A 1 247 ? -6.93518  23.72017 -10.84660 1.000 13.17982 ? 247  ILE A CD1 1 
ATOM   1998 N  N   . GLU A 1 248 ? -5.59460  18.41896 -9.82686  1.000 12.48501 ? 248  GLU A N   1 
ATOM   1999 C  CA  . GLU A 1 248 ? -5.64679  16.99843 -10.16699 1.000 11.75971 ? 248  GLU A CA  1 
ATOM   2000 C  C   . GLU A 1 248 ? -5.60345  16.13001 -8.91473  1.000 12.74847 ? 248  GLU A C   1 
ATOM   2001 O  O   . GLU A 1 248 ? -6.36974  15.17071 -8.77781  1.000 12.88911 ? 248  GLU A O   1 
ATOM   2002 C  CB  . GLU A 1 248 ? -4.48167  16.65774 -11.10147 1.000 13.20374 ? 248  GLU A CB  1 
ATOM   2003 C  CG  . GLU A 1 248 ? -4.36845  15.17627 -11.45091 1.000 13.82408 ? 248  GLU A CG  1 
ATOM   2004 C  CD  . GLU A 1 248 ? -3.42490  14.94312 -12.61989 1.000 19.33405 ? 248  GLU A CD  1 
ATOM   2005 O  OE1 . GLU A 1 248 ? -2.50073  15.75939 -12.80477 1.000 24.44012 ? 248  GLU A OE1 1 
ATOM   2006 O  OE2 . GLU A 1 248 ? -3.61431  13.95695 -13.35816 1.000 23.90247 ? 248  GLU A OE2 1 
ATOM   2007 N  N   . LYS A 1 249 ? -4.69332  16.45352 -7.99266  1.000 14.15348 ? 249  LYS A N   1 
ATOM   2008 C  CA  . LYS A 1 249 ? -4.59599  15.72020 -6.73570  1.000 15.32943 ? 249  LYS A CA  1 
ATOM   2009 C  C   . LYS A 1 249 ? -5.91841  15.75110 -5.98367  1.000 15.54887 ? 249  LYS A C   1 
ATOM   2010 O  O   . LYS A 1 249 ? -6.34600  14.74406 -5.40644  1.000 13.68993 ? 249  LYS A O   1 
ATOM   2011 C  CB  . LYS A 1 249 ? -3.47216  16.32508 -5.89128  1.000 11.43323 ? 249  LYS A CB  1 
ATOM   2012 C  CG  . LYS A 1 249 ? -3.25608  15.69179 -4.52776  1.000 17.89977 ? 249  LYS A CG  1 
ATOM   2013 C  CD  . LYS A 1 249 ? -1.94510  16.22092 -3.89451  1.000 18.66461 ? 249  LYS A CD  1 
ATOM   2014 C  CE  . LYS A 1 249 ? -1.61895  15.48777 -2.58490  1.000 23.17112 ? 249  LYS A CE  1 
ATOM   2015 N  NZ  . LYS A 1 249 ? -0.39011  16.03842 -1.95483  1.000 33.96212 ? 249  LYS A NZ  1 
ATOM   2016 N  N   . THR A 1 250 ? -6.58378  16.90161 -5.99606  1.000 13.81443 ? 250  THR A N   1 
ATOM   2017 C  CA  . THR A 1 250 ? -7.84294  17.05522 -5.28457  1.000 12.77757 ? 250  THR A CA  1 
ATOM   2018 C  C   . THR A 1 250 ? -8.93032  16.18722 -5.90780  1.000 13.15140 ? 250  THR A C   1 
ATOM   2019 O  O   . THR A 1 250 ? -9.57175  15.38716 -5.21708  1.000 14.03914 ? 250  THR A O   1 
ATOM   2020 C  CB  . THR A 1 250 ? -8.23631  18.53404 -5.28964  1.000 14.74355 ? 250  THR A CB  1 
ATOM   2021 O  OG1 . THR A 1 250 ? -7.13861  19.30888 -4.78336  1.000 11.50733 ? 250  THR A OG1 1 
ATOM   2022 C  CG2 . THR A 1 250 ? -9.46474  18.78011 -4.43131  1.000 10.84023 ? 250  THR A CG2 1 
ATOM   2023 N  N   . ILE A 1 251 ? -9.13108  16.31312 -7.22087  1.000 13.20257 ? 251  ILE A N   1 
ATOM   2024 C  CA  . ILE A 1 251 ? -10.15164 15.52055 -7.89990  1.000 13.97902 ? 251  ILE A CA  1 
ATOM   2025 C  C   . ILE A 1 251 ? -9.91483  14.03295 -7.65218  1.000 17.32358 ? 251  ILE A C   1 
ATOM   2026 O  O   . ILE A 1 251 ? -10.84535 13.28261 -7.32911  1.000 13.47589 ? 251  ILE A O   1 
ATOM   2027 C  CB  . ILE A 1 251 ? -10.17340 15.84509 -9.40726  1.000 15.16949 ? 251  ILE A CB  1 
ATOM   2028 C  CG1 . ILE A 1 251 ? -10.50814 17.32247 -9.65126  1.000 13.63786 ? 251  ILE A CG1 1 
ATOM   2029 C  CG2 . ILE A 1 251 ? -11.17471 14.95650 -10.13046 1.000 14.51140 ? 251  ILE A CG2 1 
ATOM   2030 C  CD1 . ILE A 1 251 ? -11.88863 17.71254 -9.18955  1.000 18.78967 ? 251  ILE A CD1 1 
ATOM   2031 N  N   . ASN A 1 252 ? -8.66073  13.58970 -7.79210  1.000 11.80149 ? 252  ASN A N   1 
ATOM   2032 C  CA  . ASN A 1 252 ? -8.35638  12.17584 -7.60298  1.000 18.25338 ? 252  ASN A CA  1 
ATOM   2033 C  C   . ASN A 1 252 ? -8.63629  11.75257 -6.17263  1.000 13.81138 ? 252  ASN A C   1 
ATOM   2034 O  O   . ASN A 1 252 ? -9.15582  10.65924 -5.93073  1.000 18.70326 ? 252  ASN A O   1 
ATOM   2035 C  CB  . ASN A 1 252 ? -6.89429  11.89300 -7.95964  1.000 15.66160 ? 252  ASN A CB  1 
ATOM   2036 C  CG  . ASN A 1 252 ? -6.66346  11.83402 -9.45002  1.000 17.49549 ? 252  ASN A CG  1 
ATOM   2037 O  OD1 . ASN A 1 252 ? -7.60310  11.72459 -10.22377 1.000 17.38688 ? 252  ASN A OD1 1 
ATOM   2038 N  ND2 . ASN A 1 252 ? -5.40715  11.89265 -9.85936  1.000 14.03543 ? 252  ASN A ND2 1 
ATOM   2039 N  N   . MET A 1 253 ? -8.30268  12.61477 -5.21489  1.000 16.50344 ? 253  MET A N   1 
ATOM   2040 C  CA  . MET A 1 253 ? -8.47045  12.27743 -3.80693  1.000 16.16388 ? 253  MET A CA  1 
ATOM   2041 C  C   . MET A 1 253 ? -9.92767  11.96268 -3.48748  1.000 19.47582 ? 253  MET A C   1 
ATOM   2042 O  O   . MET A 1 253 ? -10.23953 10.92184 -2.89175  1.000 17.57279 ? 253  MET A O   1 
ATOM   2043 C  CB  . MET A 1 253 ? -7.95322  13.42413 -2.94323  1.000 16.33018 ? 253  MET A CB  1 
ATOM   2044 C  CG  . MET A 1 253 ? -7.76647  13.05378 -1.49199  1.000 16.36525 ? 253  MET A CG  1 
ATOM   2045 S  SD  . MET A 1 253 ? -7.17698  14.44294 -0.52841  1.000 25.75341 ? 253  MET A SD  1 
ATOM   2046 C  CE  . MET A 1 253 ? -5.70145  14.89131 -1.41300  1.000 16.64239 ? 253  MET A CE  1 
ATOM   2047 N  N   . PHE A 1 254 ? -10.84264 12.84009 -3.90336  1.000 17.07528 ? 254  PHE A N   1 
ATOM   2048 C  CA  . PHE A 1 254 ? -12.25217 12.59764 -3.62194  1.000 16.39728 ? 254  PHE A CA  1 
ATOM   2049 C  C   . PHE A 1 254 ? -12.81598 11.48779 -4.49054  1.000 14.53329 ? 254  PHE A C   1 
ATOM   2050 O  O   . PHE A 1 254 ? -13.72237 10.77188 -4.05796  1.000 15.26860 ? 254  PHE A O   1 
ATOM   2051 C  CB  . PHE A 1 254 ? -13.05118 13.88781 -3.79444  1.000 12.50224 ? 254  PHE A CB  1 
ATOM   2052 C  CG  . PHE A 1 254 ? -12.74861 14.90158 -2.74327  1.000 12.64004 ? 254  PHE A CG  1 
ATOM   2053 C  CD1 . PHE A 1 254 ? -13.19241 14.71640 -1.44421  1.000 12.58127 ? 254  PHE A CD1 1 
ATOM   2054 C  CD2 . PHE A 1 254 ? -11.97839 16.01486 -3.03700  1.000 14.88074 ? 254  PHE A CD2 1 
ATOM   2055 C  CE1 . PHE A 1 254 ? -12.90470 15.64012 -0.45489  1.000 11.32413 ? 254  PHE A CE1 1 
ATOM   2056 C  CE2 . PHE A 1 254 ? -11.68463 16.94616 -2.06256  1.000 13.62375 ? 254  PHE A CE2 1 
ATOM   2057 C  CZ  . PHE A 1 254 ? -12.15101 16.75700 -0.76165  1.000 14.66777 ? 254  PHE A CZ  1 
ATOM   2058 N  N   . ALA A 1 255 ? -12.28928 11.30855 -5.70050  1.000 13.04514 ? 255  ALA A N   1 
ATOM   2059 C  CA  . ALA A 1 255 ? -12.77878 10.21239 -6.52916  1.000 16.46355 ? 255  ALA A CA  1 
ATOM   2060 C  C   . ALA A 1 255 ? -12.45732 8.86263  -5.89991  1.000 18.92627 ? 255  ALA A C   1 
ATOM   2061 O  O   . ALA A 1 255 ? -13.19178 7.88875  -6.10645  1.000 16.70056 ? 255  ALA A O   1 
ATOM   2062 C  CB  . ALA A 1 255 ? -12.17998 10.29144 -7.93210  1.000 15.94082 ? 255  ALA A CB  1 
ATOM   2063 N  N   . ALA A 1 256 ? -11.37273 8.78893  -5.12329  1.000 15.04986 ? 256  ALA A N   1 
ATOM   2064 C  CA  . ALA A 1 256 ? -10.99722 7.52922  -4.48697  1.000 21.27680 ? 256  ALA A CA  1 
ATOM   2065 C  C   . ALA A 1 256 ? -12.02124 7.09676  -3.45638  1.000 17.78363 ? 256  ALA A C   1 
ATOM   2066 O  O   . ALA A 1 256 ? -12.11649 5.90433  -3.16499  1.000 21.57898 ? 256  ALA A O   1 
ATOM   2067 C  CB  . ALA A 1 256 ? -9.61664  7.63846  -3.82981  1.000 16.86143 ? 256  ALA A CB  1 
ATOM   2068 N  N   . LEU A 1 257 ? -12.79591 8.03233  -2.91939  1.000 16.83106 ? 257  LEU A N   1 
ATOM   2069 C  CA  . LEU A 1 257 ? -13.88491 7.70923  -2.00915  1.000 18.34370 ? 257  LEU A CA  1 
ATOM   2070 C  C   . LEU A 1 257 ? -15.14739 7.29307  -2.73061  1.000 19.67301 ? 257  LEU A C   1 
ATOM   2071 O  O   . LEU A 1 257 ? -16.17512 7.11032  -2.07703  1.000 24.73031 ? 257  LEU A O   1 
ATOM   2072 C  CB  . LEU A 1 257 ? -14.19199 8.90488  -1.10755  1.000 18.36349 ? 257  LEU A CB  1 
ATOM   2073 C  CG  . LEU A 1 257 ? -13.18408 9.27118  -0.02436  1.000 25.81417 ? 257  LEU A CG  1 
ATOM   2074 C  CD1 . LEU A 1 257 ? -13.63509 10.54585 0.67293   1.000 21.18301 ? 257  LEU A CD1 1 
ATOM   2075 C  CD2 . LEU A 1 257 ? -12.99283 8.12835  0.98617   1.000 24.88297 ? 257  LEU A CD2 1 
ATOM   2076 N  N   . GLY A 1 258 ? -15.10309 7.13641  -4.05316  1.000 19.72319 ? 258  GLY A N   1 
ATOM   2077 C  CA  . GLY A 1 258 ? -16.31077 6.85719  -4.80219  1.000 15.64805 ? 258  GLY A CA  1 
ATOM   2078 C  C   . GLY A 1 258 ? -17.20338 8.05873  -5.03278  1.000 19.17698 ? 258  GLY A C   1 
ATOM   2079 O  O   . GLY A 1 258 ? -18.37473 7.89039  -5.37678  1.000 20.94020 ? 258  GLY A O   1 
ATOM   2080 N  N   . LEU A 1 259 ? -16.68007 9.27087  -4.87947  1.000 13.67743 ? 259  LEU A N   1 
ATOM   2081 C  CA  . LEU A 1 259 ? -17.47257 10.48006 -5.03856  1.000 16.86701 ? 259  LEU A CA  1 
ATOM   2082 C  C   . LEU A 1 259 ? -17.39133 11.00934 -6.46302  1.000 13.90706 ? 259  LEU A C   1 
ATOM   2083 O  O   . LEU A 1 259 ? -16.32039 11.01736 -7.07134  1.000 12.95238 ? 259  LEU A O   1 
ATOM   2084 C  CB  . LEU A 1 259 ? -16.99209 11.56267 -4.07135  1.000 16.22978 ? 259  LEU A CB  1 
ATOM   2085 C  CG  . LEU A 1 259 ? -17.16744 11.24430 -2.58471  1.000 16.78578 ? 259  LEU A CG  1 
ATOM   2086 C  CD1 . LEU A 1 259 ? -16.27821 12.15797 -1.72311  1.000 17.43128 ? 259  LEU A CD1 1 
ATOM   2087 C  CD2 . LEU A 1 259 ? -18.61761 11.37326 -2.18706  1.000 13.85842 ? 259  LEU A CD2 1 
ATOM   2088 N  N   . ASP A 1 260 ? -18.53355 11.44293 -6.98975  1.000 10.29787 ? 260  ASP A N   1 
ATOM   2089 C  CA  . ASP A 1 260 ? -18.54259 12.29911 -8.16761  1.000 11.42463 ? 260  ASP A CA  1 
ATOM   2090 C  C   . ASP A 1 260 ? -17.89683 13.64244 -7.82524  1.000 9.94904  ? 260  ASP A C   1 
ATOM   2091 O  O   . ASP A 1 260 ? -17.90147 14.08576 -6.67607  1.000 9.07322  ? 260  ASP A O   1 
ATOM   2092 C  CB  . ASP A 1 260 ? -19.98420 12.49663 -8.65449  1.000 11.07357 ? 260  ASP A CB  1 
ATOM   2093 C  CG  . ASP A 1 260 ? -20.08071 13.24481 -9.98516  1.000 14.92445 ? 260  ASP A CG  1 
ATOM   2094 O  OD1 . ASP A 1 260 ? -19.22338 13.04844 -10.87315 1.000 9.76294  ? 260  ASP A OD1 1 
ATOM   2095 O  OD2 . ASP A 1 260 ? -21.05087 14.01882 -10.14767 1.000 11.19666 ? 260  ASP A OD2 1 
ATOM   2096 N  N   . ASN A 1 261 ? -17.31831 14.28448 -8.82962  1.000 10.24393 ? 261  ASN A N   1 
ATOM   2097 C  CA  . ASN A 1 261 ? -16.83275 15.65301 -8.70713  1.000 7.89816  ? 261  ASN A CA  1 
ATOM   2098 C  C   . ASN A 1 261 ? -17.57046 16.53464 -9.70360  1.000 12.47911 ? 261  ASN A C   1 
ATOM   2099 O  O   . ASN A 1 261 ? -17.64763 16.19971 -10.89128 1.000 11.29132 ? 261  ASN A O   1 
ATOM   2100 C  CB  . ASN A 1 261 ? -15.33754 15.74007 -8.97724  1.000 9.69064  ? 261  ASN A CB  1 
ATOM   2101 C  CG  . ASN A 1 261 ? -14.53794 14.95016 -7.98845  1.000 12.32186 ? 261  ASN A CG  1 
ATOM   2102 O  OD1 . ASN A 1 261 ? -14.27444 15.42114 -6.88048  1.000 12.59848 ? 261  ASN A OD1 1 
ATOM   2103 N  ND2 . ASN A 1 261 ? -14.16750 13.73078 -8.36397  1.000 10.96325 ? 261  ASN A ND2 1 
ATOM   2104 N  N   . GLN A 1 262 ? -18.09303 17.66237 -9.23309  1.000 9.20753  ? 262  GLN A N   1 
ATOM   2105 C  CA  . GLN A 1 262 ? -18.59801 18.68372 -10.13331 1.000 9.47727  ? 262  GLN A CA  1 
ATOM   2106 C  C   . GLN A 1 262 ? -17.87471 19.99117 -9.85946  1.000 8.77583  ? 262  GLN A C   1 
ATOM   2107 O  O   . GLN A 1 262 ? -17.57083 20.31623 -8.71030  1.000 8.28485  ? 262  GLN A O   1 
ATOM   2108 C  CB  . GLN A 1 262 ? -20.10980 18.84741 -10.00648 1.000 7.74278  ? 262  GLN A CB  1 
ATOM   2109 C  CG  . GLN A 1 262 ? -20.86173 17.54750 -10.31462 1.000 9.18411  ? 262  GLN A CG  1 
ATOM   2110 C  CD  . GLN A 1 262 ? -22.37512 17.72367 -10.42832 1.000 10.86096 ? 262  GLN A CD  1 
ATOM   2111 O  OE1 . GLN A 1 262 ? -22.99990 18.38806 -9.59771  1.000 11.32446 ? 262  GLN A OE1 1 
ATOM   2112 N  NE2 . GLN A 1 262 ? -22.97304 17.10827 -11.45438 1.000 11.20914 ? 262  GLN A NE2 1 
ATOM   2113 N  N   . ILE A 1 263 ? -17.54359 20.69222 -10.93905 1.000 8.95250  ? 263  ILE A N   1 
ATOM   2114 C  CA  . ILE A 1 263 ? -17.00562 22.04575 -10.88402 1.000 8.01028  ? 263  ILE A CA  1 
ATOM   2115 C  C   . ILE A 1 263 ? -18.20783 22.97680 -10.93517 1.000 7.76565  ? 263  ILE A C   1 
ATOM   2116 O  O   . ILE A 1 263 ? -18.86976 23.07031 -11.97134 1.000 9.56782  ? 263  ILE A O   1 
ATOM   2117 C  CB  . ILE A 1 263 ? -16.04675 22.30625 -12.05676 1.000 8.28092  ? 263  ILE A CB  1 
ATOM   2118 C  CG1 . ILE A 1 263 ? -15.03511 21.16703 -12.20288 1.000 11.96054 ? 263  ILE A CG1 1 
ATOM   2119 C  CG2 . ILE A 1 263 ? -15.36450 23.66336 -11.92659 1.000 11.71574 ? 263  ILE A CG2 1 
ATOM   2120 C  CD1 . ILE A 1 263 ? -14.27199 20.84450 -10.94539 1.000 12.40391 ? 263  ILE A CD1 1 
ATOM   2121 N  N   . THR A 1 264 ? -18.51307 23.65983 -9.82362  1.000 7.61836  ? 264  THR A N   1 
ATOM   2122 C  CA  . THR A 1 264 ? -19.82737 24.28787 -9.69979  1.000 9.25907  ? 264  THR A CA  1 
ATOM   2123 C  C   . THR A 1 264 ? -19.84140 25.80099 -9.86552  1.000 9.09461  ? 264  THR A C   1 
ATOM   2124 O  O   . THR A 1 264 ? -20.92383 26.35584 -10.06975 1.000 9.64792  ? 264  THR A O   1 
ATOM   2125 C  CB  . THR A 1 264 ? -20.47849 23.95622 -8.34126  1.000 7.35313  ? 264  THR A CB  1 
ATOM   2126 O  OG1 . THR A 1 264 ? -19.73740 24.57511 -7.28753  1.000 9.63624  ? 264  THR A OG1 1 
ATOM   2127 C  CG2 . THR A 1 264 ? -20.51659 22.43768 -8.11290  1.000 9.76300  ? 264  THR A CG2 1 
ATOM   2128 N  N   . GLY A 1 265 ? -18.69957 26.48488 -9.77805  1.000 6.59540  ? 265  GLY A N   1 
ATOM   2129 C  CA  . GLY A 1 265 ? -18.72759 27.94181 -9.79962  1.000 8.25061  ? 265  GLY A CA  1 
ATOM   2130 C  C   . GLY A 1 265 ? -17.52309 28.53183 -10.49711 1.000 8.99961  ? 265  GLY A C   1 
ATOM   2131 O  O   . GLY A 1 265 ? -16.99854 29.58540 -10.10815 1.000 8.88639  ? 265  GLY A O   1 
ATOM   2132 N  N   . LEU A 1 266 ? -17.07281 27.84163 -11.53484 1.000 7.76241  ? 266  LEU A N   1 
ATOM   2133 C  CA  . LEU A 1 266 ? -15.79118 28.16001 -12.15147 1.000 8.08084  ? 266  LEU A CA  1 
ATOM   2134 C  C   . LEU A 1 266 ? -15.75304 29.61181 -12.61279 1.000 7.32367  ? 266  LEU A C   1 
ATOM   2135 O  O   . LEU A 1 266 ? -16.64426 30.07972 -13.33063 1.000 7.90433  ? 266  LEU A O   1 
ATOM   2136 C  CB  . LEU A 1 266 ? -15.53832 27.23056 -13.33629 1.000 5.68394  ? 266  LEU A CB  1 
ATOM   2137 C  CG  . LEU A 1 266 ? -14.29074 27.53171 -14.16236 1.000 9.64967  ? 266  LEU A CG  1 
ATOM   2138 C  CD1 . LEU A 1 266 ? -13.02467 27.47583 -13.27633 1.000 5.94203  ? 266  LEU A CD1 1 
ATOM   2139 C  CD2 . LEU A 1 266 ? -14.21091 26.52300 -15.31568 1.000 7.40937  ? 266  LEU A CD2 1 
ATOM   2140 N  N   . ASP A 1 267 ? -14.73333 30.33371 -12.16255 1.000 7.38268  ? 267  ASP A N   1 
ATOM   2141 C  CA  . ASP A 1 267 ? -14.35888 31.59051 -12.79135 1.000 9.14761  ? 267  ASP A CA  1 
ATOM   2142 C  C   . ASP A 1 267 ? -12.85894 31.76553 -12.61140 1.000 9.41193  ? 267  ASP A C   1 
ATOM   2143 O  O   . ASP A 1 267 ? -12.29510 31.35246 -11.59243 1.000 8.09568  ? 267  ASP A O   1 
ATOM   2144 C  CB  . ASP A 1 267 ? -15.16132 32.79614 -12.24961 1.000 5.86424  ? 267  ASP A CB  1 
ATOM   2145 C  CG  . ASP A 1 267 ? -15.46380 32.71071 -10.74362 1.000 9.80510  ? 267  ASP A CG  1 
ATOM   2146 O  OD1 . ASP A 1 267 ? -14.56343 32.32771 -9.95863  1.000 9.89614  ? 267  ASP A OD1 1 
ATOM   2147 O  OD2 . ASP A 1 267 ? -16.61553 33.04008 -10.35488 1.000 8.70312  ? 267  ASP A OD2 1 
ATOM   2148 N  N   . VAL A 1 268 ? -12.20711 32.30866 -13.63898 1.000 6.57931  ? 268  VAL A N   1 
ATOM   2149 C  CA  . VAL A 1 268 ? -10.76719 32.53104 -13.58472 1.000 7.98807  ? 268  VAL A CA  1 
ATOM   2150 C  C   . VAL A 1 268 ? -10.54534 34.02697 -13.48039 1.000 7.99392  ? 268  VAL A C   1 
ATOM   2151 O  O   . VAL A 1 268 ? -10.51940 34.73512 -14.49369 1.000 6.98341  ? 268  VAL A O   1 
ATOM   2152 C  CB  . VAL A 1 268 ? -10.05319 31.93697 -14.81198 1.000 8.46982  ? 268  VAL A CB  1 
ATOM   2153 C  CG1 . VAL A 1 268 ? -8.51794  32.19423 -14.74086 1.000 10.54400 ? 268  VAL A CG1 1 
ATOM   2154 C  CG2 . VAL A 1 268 ? -10.35065 30.43907 -14.90842 1.000 6.56932  ? 268  VAL A CG2 1 
ATOM   2155 N  N   . SER A 1 269 ? -10.41123 34.51087 -12.25171 1.000 10.75917 ? 269  SER A N   1 
ATOM   2156 C  CA  . SER A 1 269 ? -10.19191 35.92702 -12.00004 1.000 8.07547  ? 269  SER A CA  1 
ATOM   2157 C  C   . SER A 1 269 ? -8.92133  36.41975 -12.67851 1.000 12.00764 ? 269  SER A C   1 
ATOM   2158 O  O   . SER A 1 269 ? -7.93967  35.67976 -12.84231 1.000 10.21160 ? 269  SER A O   1 
ATOM   2159 C  CB  . SER A 1 269 ? -10.09570 36.17747 -10.49445 1.000 9.64850  ? 269  SER A CB  1 
ATOM   2160 O  OG  . SER A 1 269 ? -9.78136  37.53696 -10.21909 1.000 12.21473 ? 269  SER A OG  1 
ATOM   2161 N  N   . MET A 1 270 ? -8.93353  37.69137 -13.07243 1.000 8.29447  ? 270  MET A N   1 
ATOM   2162 C  CA  . MET A 1 270 ? -7.72311  38.30742 -13.59360 1.000 9.46427  ? 270  MET A CA  1 
ATOM   2163 C  C   . MET A 1 270 ? -6.74956  38.70553 -12.49648 1.000 12.64254 ? 270  MET A C   1 
ATOM   2164 O  O   . MET A 1 270 ? -5.60918  39.06492 -12.81151 1.000 9.62603  ? 270  MET A O   1 
ATOM   2165 C  CB  . MET A 1 270 ? -8.06111  39.54855 -14.42486 1.000 10.95012 ? 270  MET A CB  1 
ATOM   2166 C  CG  . MET A 1 270 ? -8.74051  39.26184 -15.75780 1.000 9.77018  ? 270  MET A CG  1 
ATOM   2167 S  SD  . MET A 1 270 ? -7.70165  38.26277 -16.85350 1.000 13.04069 ? 270  MET A SD  1 
ATOM   2168 C  CE  . MET A 1 270 ? -8.62961  38.46335 -18.37486 1.000 10.73429 ? 270  MET A CE  1 
ATOM   2169 N  N   . TYR A 1 271 ? -7.15550  38.64163 -11.22728 1.000 10.04712 ? 271  TYR A N   1 
ATOM   2170 C  CA  . TYR A 1 271 ? -6.38862  39.26450 -10.15522 1.000 12.91458 ? 271  TYR A CA  1 
ATOM   2171 C  C   . TYR A 1 271 ? -5.92135  38.24091 -9.12413  1.000 13.83369 ? 271  TYR A C   1 
ATOM   2172 O  O   . TYR A 1 271 ? -6.24640  37.05435 -9.18786  1.000 12.14303 ? 271  TYR A O   1 
ATOM   2173 C  CB  . TYR A 1 271 ? -7.21691  40.37144 -9.48820  1.000 10.70515 ? 271  TYR A CB  1 
ATOM   2174 C  CG  . TYR A 1 271 ? -7.81580  41.30316 -10.52384 1.000 8.82902  ? 271  TYR A CG  1 
ATOM   2175 C  CD1 . TYR A 1 271 ? -6.99126  42.02927 -11.36913 1.000 12.22517 ? 271  TYR A CD1 1 
ATOM   2176 C  CD2 . TYR A 1 271 ? -9.19411  41.42110 -10.68835 1.000 10.25081 ? 271  TYR A CD2 1 
ATOM   2177 C  CE1 . TYR A 1 271 ? -7.51104  42.87716 -12.34258 1.000 10.86088 ? 271  TYR A CE1 1 
ATOM   2178 C  CE2 . TYR A 1 271 ? -9.73234  42.27011 -11.67413 1.000 9.49087  ? 271  TYR A CE2 1 
ATOM   2179 C  CZ  . TYR A 1 271 ? -8.87312  42.99038 -12.49238 1.000 9.40463  ? 271  TYR A CZ  1 
ATOM   2180 O  OH  . TYR A 1 271 ? -9.35540  43.83620 -13.45716 1.000 11.57765 ? 271  TYR A OH  1 
ATOM   2181 N  N   . GLY A 1 272 ? -5.11103  38.71925 -8.18591  1.000 13.04196 ? 272  GLY A N   1 
ATOM   2182 C  CA  . GLY A 1 272 ? -4.70141  37.94647 -7.03633  1.000 17.63004 ? 272  GLY A CA  1 
ATOM   2183 C  C   . GLY A 1 272 ? -5.69704  38.06719 -5.90493  1.000 15.75616 ? 272  GLY A C   1 
ATOM   2184 O  O   . GLY A 1 272 ? -6.89171  38.29345 -6.11534  1.000 12.71684 ? 272  GLY A O   1 
ATOM   2185 N  N   . TRP A 1 273 ? -5.19593  37.93134 -4.67876  1.000 17.69880 ? 273  TRP A N   1 
ATOM   2186 C  CA  . TRP A 1 273 ? -6.07644  38.05405 -3.52196  1.000 20.27505 ? 273  TRP A CA  1 
ATOM   2187 C  C   . TRP A 1 273 ? -5.31747  38.67218 -2.35360  1.000 20.33656 ? 273  TRP A C   1 
ATOM   2188 O  O   . TRP A 1 273 ? -4.27086  38.14853 -1.95643  1.000 22.07686 ? 273  TRP A O   1 
ATOM   2189 C  CB  . TRP A 1 273 ? -6.65938  36.69895 -3.11251  1.000 13.72524 ? 273  TRP A CB  1 
ATOM   2190 C  CG  . TRP A 1 273 ? -7.61843  36.85583 -1.97970  1.000 20.71545 ? 273  TRP A CG  1 
ATOM   2191 C  CD1 . TRP A 1 273 ? -7.34137  36.74319 -0.64952  1.000 22.87769 ? 273  TRP A CD1 1 
ATOM   2192 C  CD2 . TRP A 1 273 ? -9.01094  37.19477 -2.07200  1.000 20.46936 ? 273  TRP A CD2 1 
ATOM   2193 N  NE1 . TRP A 1 273 ? -8.47682  36.97426 0.09169   1.000 27.57976 ? 273  TRP A NE1 1 
ATOM   2194 C  CE2 . TRP A 1 273 ? -9.51551  37.25108 -0.75832  1.000 24.76306 ? 273  TRP A CE2 1 
ATOM   2195 C  CE3 . TRP A 1 273 ? -9.87815  37.45097 -3.13836  1.000 16.89501 ? 273  TRP A CE3 1 
ATOM   2196 C  CZ2 . TRP A 1 273 ? -10.84795 37.55294 -0.48073  1.000 25.40415 ? 273  TRP A CZ2 1 
ATOM   2197 C  CZ3 . TRP A 1 273 ? -11.20660 37.75108 -2.85847  1.000 19.86148 ? 273  TRP A CZ3 1 
ATOM   2198 C  CH2 . TRP A 1 273 ? -11.67349 37.80190 -1.54103  1.000 22.75629 ? 273  TRP A CH2 1 
ATOM   2199 N  N   . PRO A 1 274 ? -5.79507  39.79213 -1.78331  1.000 20.09679 ? 274  PRO A N   1 
ATOM   2200 C  CA  . PRO A 1 274 ? -6.99772  40.52509 -2.20077  1.000 15.72619 ? 274  PRO A CA  1 
ATOM   2201 C  C   . PRO A 1 274 ? -6.80092  41.18150 -3.56298  1.000 15.80619 ? 274  PRO A C   1 
ATOM   2202 O  O   . PRO A 1 274 ? -5.67697  41.58642 -3.87473  1.000 12.78126 ? 274  PRO A O   1 
ATOM   2203 C  CB  . PRO A 1 274 ? -7.17807  41.58816 -1.09649  1.000 18.72575 ? 274  PRO A CB  1 
ATOM   2204 C  CG  . PRO A 1 274 ? -6.22331  41.19205 0.01064   1.000 23.61595 ? 274  PRO A CG  1 
ATOM   2205 C  CD  . PRO A 1 274 ? -5.10129  40.46924 -0.67469  1.000 20.99965 ? 274  PRO A CD  1 
ATOM   2206 N  N   . PRO A 1 275 ? -7.86078  41.26833 -4.37101  1.000 15.19115 ? 275  PRO A N   1 
ATOM   2207 C  CA  . PRO A 1 275 ? -7.68215  41.75119 -5.74540  1.000 12.93627 ? 275  PRO A CA  1 
ATOM   2208 C  C   . PRO A 1 275 ? -7.37501  43.24255 -5.78920  1.000 12.60268 ? 275  PRO A C   1 
ATOM   2209 O  O   . PRO A 1 275 ? -7.92520  44.04184 -5.02481  1.000 11.17237 ? 275  PRO A O   1 
ATOM   2210 C  CB  . PRO A 1 275 ? -9.02832  41.43557 -6.42181  1.000 14.76628 ? 275  PRO A CB  1 
ATOM   2211 C  CG  . PRO A 1 275 ? -9.79720  40.56170 -5.45074  1.000 13.81839 ? 275  PRO A CG  1 
ATOM   2212 C  CD  . PRO A 1 275 ? -9.26687  40.92400 -4.08846  1.000 14.77836 ? 275  PRO A CD  1 
ATOM   2213 N  N   . ARG A 1 276 ? -6.49207  43.60988 -6.70663  1.000 12.23218 ? 276  ARG A N   1 
ATOM   2214 C  CA  . ARG A 1 276 ? -6.26610  45.00238 -7.09378  1.000 11.85106 ? 276  ARG A CA  1 
ATOM   2215 C  C   . ARG A 1 276 ? -6.71265  45.10281 -8.55046  1.000 8.84452  ? 276  ARG A C   1 
ATOM   2216 O  O   . ARG A 1 276 ? -5.95015  44.81965 -9.47705  1.000 8.93754  ? 276  ARG A O   1 
ATOM   2217 C  CB  . ARG A 1 276 ? -4.81293  45.40271 -6.90648  1.000 11.98646 ? 276  ARG A CB  1 
ATOM   2218 C  CG  . ARG A 1 276 ? -4.35910  45.26288 -5.45338  1.000 14.21770 ? 276  ARG A CG  1 
ATOM   2219 C  CD  . ARG A 1 276 ? -3.08865  46.06767 -5.15326  1.000 15.99270 ? 276  ARG A CD  1 
ATOM   2220 N  NE  . ARG A 1 276 ? -2.81379  46.09423 -3.71463  1.000 18.54241 ? 276  ARG A NE  1 
ATOM   2221 C  CZ  . ARG A 1 276 ? -1.84467  46.80909 -3.14487  1.000 18.74849 ? 276  ARG A CZ  1 
ATOM   2222 N  NH1 . ARG A 1 276 ? -1.04102  47.56203 -3.88795  1.000 17.16087 ? 276  ARG A NH1 1 
ATOM   2223 N  NH2 . ARG A 1 276 ? -1.69832  46.78080 -1.82988  1.000 17.38540 ? 276  ARG A NH2 1 
ATOM   2224 N  N   . ALA A 1 277 ? -7.95673  45.50209 -8.73938  1.000 10.13714 ? 277  ALA A N   1 
ATOM   2225 C  CA  . ALA A 1 277 ? -8.59782  45.42334 -10.04008 1.000 11.73738 ? 277  ALA A CA  1 
ATOM   2226 C  C   . ALA A 1 277 ? -8.33440  46.67359 -10.87299 1.000 11.28120 ? 277  ALA A C   1 
ATOM   2227 O  O   . ALA A 1 277 ? -8.04940  47.75604 -10.35375 1.000 11.92291 ? 277  ALA A O   1 
ATOM   2228 C  CB  . ALA A 1 277 ? -10.10334 45.23299 -9.87355  1.000 7.99040  ? 277  ALA A CB  1 
ATOM   2229 N  N   . TYR A 1 278 ? -8.45032  46.50973 -12.18374 1.000 10.61479 ? 278  TYR A N   1 
ATOM   2230 C  CA  . TYR A 1 278 ? -8.58218  47.66485 -13.05249 1.000 10.80287 ? 278  TYR A CA  1 
ATOM   2231 C  C   . TYR A 1 278 ? -9.98141  48.25927 -12.89796 1.000 12.99936 ? 278  TYR A C   1 
ATOM   2232 O  O   . TYR A 1 278 ? -10.92564 47.55190 -12.51720 1.000 10.91225 ? 278  TYR A O   1 
ATOM   2233 C  CB  . TYR A 1 278 ? -8.32707  47.27451 -14.50733 1.000 11.54947 ? 278  TYR A CB  1 
ATOM   2234 C  CG  . TYR A 1 278 ? -6.87973  46.92356 -14.76832 1.000 13.41343 ? 278  TYR A CG  1 
ATOM   2235 C  CD1 . TYR A 1 278 ? -5.92908  47.91698 -15.01032 1.000 11.83538 ? 278  TYR A CD1 1 
ATOM   2236 C  CD2 . TYR A 1 278 ? -6.45639  45.60019 -14.74392 1.000 11.25342 ? 278  TYR A CD2 1 
ATOM   2237 C  CE1 . TYR A 1 278 ? -4.58641  47.58431 -15.24286 1.000 11.35050 ? 278  TYR A CE1 1 
ATOM   2238 C  CE2 . TYR A 1 278 ? -5.13884  45.26620 -14.96047 1.000 13.27609 ? 278  TYR A CE2 1 
ATOM   2239 C  CZ  . TYR A 1 278 ? -4.20959  46.25997 -15.21265 1.000 14.22996 ? 278  TYR A CZ  1 
ATOM   2240 O  OH  . TYR A 1 278 ? -2.90672  45.90122 -15.42328 1.000 17.12924 ? 278  TYR A OH  1 
ATOM   2241 N  N   . PRO A 1 279 ? -10.13981 49.56290 -13.16706 1.000 10.89284 ? 279  PRO A N   1 
ATOM   2242 C  CA  . PRO A 1 279 ? -11.44681 50.19804 -12.93595 1.000 11.90025 ? 279  PRO A CA  1 
ATOM   2243 C  C   . PRO A 1 279 ? -12.49350 49.84590 -13.98046 1.000 12.27491 ? 279  PRO A C   1 
ATOM   2244 O  O   . PRO A 1 279 ? -13.69217 49.90201 -13.67723 1.000 15.60662 ? 279  PRO A O   1 
ATOM   2245 C  CB  . PRO A 1 279 ? -11.11334 51.70361 -12.96466 1.000 13.40403 ? 279  PRO A CB  1 
ATOM   2246 C  CG  . PRO A 1 279 ? -9.94386  51.80270 -13.86373 1.000 13.58335 ? 279  PRO A CG  1 
ATOM   2247 C  CD  . PRO A 1 279 ? -9.12704  50.53501 -13.62829 1.000 13.65957 ? 279  PRO A CD  1 
ATOM   2248 N  N   . THR A 1 280 ? -12.08621 49.51488 -15.19993 1.000 12.32666 ? 280  THR A N   1 
ATOM   2249 C  CA  . THR A 1 280 ? -13.01200 49.18055 -16.27356 1.000 13.16648 ? 280  THR A CA  1 
ATOM   2250 C  C   . THR A 1 280 ? -12.48858 47.95530 -17.00153 1.000 12.05086 ? 280  THR A C   1 
ATOM   2251 O  O   . THR A 1 280 ? -11.30435 47.60486 -16.90773 1.000 11.50345 ? 280  THR A O   1 
ATOM   2252 C  CB  . THR A 1 280 ? -13.15877 50.30835 -17.30305 1.000 12.54494 ? 280  THR A CB  1 
ATOM   2253 O  OG1 . THR A 1 280 ? -11.89588 50.51473 -17.94351 1.000 13.17646 ? 280  THR A OG1 1 
ATOM   2254 C  CG2 . THR A 1 280 ? -13.58786 51.61336 -16.62970 1.000 20.10279 ? 280  THR A CG2 1 
ATOM   2255 N  N   . TYR A 1 281 ? -13.37906 47.33701 -17.77423 1.000 12.12325 ? 281  TYR A N   1 
ATOM   2256 C  CA  . TYR A 1 281 ? -12.97134 46.24996 -18.65606 1.000 13.03118 ? 281  TYR A CA  1 
ATOM   2257 C  C   . TYR A 1 281 ? -11.95006 46.72213 -19.67318 1.000 13.33470 ? 281  TYR A C   1 
ATOM   2258 O  O   . TYR A 1 281 ? -11.00441 45.99711 -19.99641 1.000 10.97971 ? 281  TYR A O   1 
ATOM   2259 C  CB  . TYR A 1 281 ? -14.18819 45.68528 -19.38297 1.000 11.75160 ? 281  TYR A CB  1 
ATOM   2260 C  CG  . TYR A 1 281 ? -13.96642 44.32434 -19.96943 1.000 13.69043 ? 281  TYR A CG  1 
ATOM   2261 C  CD1 . TYR A 1 281 ? -13.49208 44.16415 -21.27032 1.000 13.43345 ? 281  TYR A CD1 1 
ATOM   2262 C  CD2 . TYR A 1 281 ? -14.25337 43.19025 -19.23097 1.000 13.18923 ? 281  TYR A CD2 1 
ATOM   2263 C  CE1 . TYR A 1 281 ? -13.31362 42.90501 -21.80778 1.000 10.95539 ? 281  TYR A CE1 1 
ATOM   2264 C  CE2 . TYR A 1 281 ? -14.06896 41.93116 -19.75691 1.000 11.95640 ? 281  TYR A CE2 1 
ATOM   2265 C  CZ  . TYR A 1 281 ? -13.60563 41.78454 -21.03732 1.000 12.30040 ? 281  TYR A CZ  1 
ATOM   2266 O  OH  . TYR A 1 281 ? -13.44101 40.49892 -21.52651 1.000 12.19998 ? 281  TYR A OH  1 
ATOM   2267 N  N   . ASP A 1 282 ? -12.14536 47.92428 -20.21568 1.000 12.37872 ? 282  ASP A N   1 
ATOM   2268 C  CA  . ASP A 1 282 ? -11.28830 48.40364 -21.29052 1.000 14.50475 ? 282  ASP A CA  1 
ATOM   2269 C  C   . ASP A 1 282 ? -9.85959  48.63504 -20.81855 1.000 15.76332 ? 282  ASP A C   1 
ATOM   2270 O  O   . ASP A 1 282 ? -8.92746  48.55930 -21.62777 1.000 12.99600 ? 282  ASP A O   1 
ATOM   2271 C  CB  . ASP A 1 282 ? -11.88056 49.68221 -21.88842 1.000 16.31566 ? 282  ASP A CB  1 
ATOM   2272 C  CG  . ASP A 1 282 ? -13.31407 49.47355 -22.39909 1.000 16.87623 ? 282  ASP A CG  1 
ATOM   2273 O  OD1 . ASP A 1 282 ? -13.63507 48.37732 -22.93030 1.000 24.86577 ? 282  ASP A OD1 1 
ATOM   2274 O  OD2 . ASP A 1 282 ? -14.10802 50.40285 -22.26700 1.000 22.83182 ? 282  ASP A OD2 1 
ATOM   2275 N  N   . ALA A 1 283 ? -9.66469  48.89309 -19.52186 1.000 11.53060 ? 283  ALA A N   1 
ATOM   2276 C  CA  . ALA A 1 283 ? -8.32994  49.13203 -18.98103 1.000 13.09512 ? 283  ALA A CA  1 
ATOM   2277 C  C   . ALA A 1 283 ? -7.52107  47.85399 -18.77667 1.000 13.19654 ? 283  ALA A C   1 
ATOM   2278 O  O   . ALA A 1 283 ? -6.32993  47.93504 -18.44326 1.000 10.30429 ? 283  ALA A O   1 
ATOM   2279 C  CB  . ALA A 1 283 ? -8.43816  49.89226 -17.64802 1.000 9.55293  ? 283  ALA A CB  1 
ATOM   2280 N  N   . ILE A 1 284 ? -8.12454  46.68024 -18.94948 1.000 11.82357 ? 284  ILE A N   1 
ATOM   2281 C  CA  . ILE A 1 284 ? -7.40837  45.42679 -18.70667 1.000 13.56547 ? 284  ILE A CA  1 
ATOM   2282 C  C   . ILE A 1 284 ? -6.50366  45.16920 -19.90892 1.000 12.57754 ? 284  ILE A C   1 
ATOM   2283 O  O   . ILE A 1 284 ? -6.99857  45.10990 -21.04445 1.000 14.24473 ? 284  ILE A O   1 
ATOM   2284 C  CB  . ILE A 1 284 ? -8.38137  44.25554 -18.46389 1.000 12.68563 ? 284  ILE A CB  1 
ATOM   2285 C  CG1 . ILE A 1 284 ? -9.31559  44.54609 -17.28421 1.000 11.29424 ? 284  ILE A CG1 1 
ATOM   2286 C  CG2 . ILE A 1 284 ? -7.61072  42.97252 -18.19411 1.000 13.00911 ? 284  ILE A CG2 1 
ATOM   2287 C  CD1 . ILE A 1 284 ? -10.39076 43.46312 -17.09602 1.000 11.04276 ? 284  ILE A CD1 1 
ATOM   2288 N  N   . PRO A 1 285 ? -5.19083  45.01500 -19.72208 1.000 11.95834 ? 285  PRO A N   1 
ATOM   2289 C  CA  . PRO A 1 285 ? -4.30286  44.83321 -20.87713 1.000 13.49372 ? 285  PRO A CA  1 
ATOM   2290 C  C   . PRO A 1 285 ? -4.59710  43.53259 -21.60399 1.000 16.81224 ? 285  PRO A C   1 
ATOM   2291 O  O   . PRO A 1 285 ? -5.01179  42.54153 -20.99990 1.000 12.84366 ? 285  PRO A O   1 
ATOM   2292 C  CB  . PRO A 1 285 ? -2.89667  44.81648 -20.25538 1.000 16.48392 ? 285  PRO A CB  1 
ATOM   2293 C  CG  . PRO A 1 285 ? -3.06422  45.37323 -18.86266 1.000 16.53256 ? 285  PRO A CG  1 
ATOM   2294 C  CD  . PRO A 1 285 ? -4.45049  44.98245 -18.44934 1.000 14.34913 ? 285  PRO A CD  1 
ATOM   2295 N  N   . LYS A 1 286 ? -4.36055  43.54783 -22.92173 1.000 16.68904 ? 286  LYS A N   1 
ATOM   2296 C  CA  . LYS A 1 286 ? -4.56863  42.35694 -23.74346 1.000 19.20120 ? 286  LYS A CA  1 
ATOM   2297 C  C   . LYS A 1 286 ? -3.78428  41.16068 -23.22974 1.000 17.35341 ? 286  LYS A C   1 
ATOM   2298 O  O   . LYS A 1 286 ? -4.25369  40.02646 -23.34502 1.000 16.82659 ? 286  LYS A O   1 
ATOM   2299 C  CB  . LYS A 1 286 ? -4.17806  42.62747 -25.19869 1.000 25.87286 ? 286  LYS A CB  1 
ATOM   2300 C  CG  . LYS A 1 286 ? -5.07272  43.63015 -25.89770 1.000 29.73333 ? 286  LYS A CG  1 
ATOM   2301 C  CD  . LYS A 1 286 ? -4.44339  44.14141 -27.18788 1.000 35.02491 ? 286  LYS A CD  1 
ATOM   2302 C  CE  . LYS A 1 286 ? -5.51316  44.56747 -28.18765 1.000 36.12997 ? 286  LYS A CE  1 
ATOM   2303 N  NZ  . LYS A 1 286 ? -5.86777  43.48734 -29.15462 1.000 34.75322 ? 286  LYS A NZ  1 
ATOM   2304 N  N   . GLN A 1 287 ? -2.58865  41.38836 -22.67343 1.000 13.03792 ? 287  GLN A N   1 
ATOM   2305 C  CA  . GLN A 1 287 ? -1.75735  40.27718 -22.21495 1.000 13.83686 ? 287  GLN A CA  1 
ATOM   2306 C  C   . GLN A 1 287 ? -2.45841  39.45126 -21.13345 1.000 15.38237 ? 287  GLN A C   1 
ATOM   2307 O  O   . GLN A 1 287 ? -2.27970  38.22915 -21.06838 1.000 16.56222 ? 287  GLN A O   1 
ATOM   2308 C  CB  . GLN A 1 287 ? -0.41917  40.80756 -21.69993 1.000 17.74821 ? 287  GLN A CB  1 
ATOM   2309 C  CG  . GLN A 1 287 ? 0.56814   39.72260 -21.30110 1.000 17.81659 ? 287  GLN A CG  1 
ATOM   2310 C  CD  . GLN A 1 287 ? 0.90748   38.79211 -22.45581 1.000 18.46492 ? 287  GLN A CD  1 
ATOM   2311 O  OE1 . GLN A 1 287 ? 1.15702   39.23800 -23.57253 1.000 22.85244 ? 287  GLN A OE1 1 
ATOM   2312 N  NE2 . GLN A 1 287 ? 0.90696   37.49188 -22.19135 1.000 18.24856 ? 287  GLN A NE2 1 
ATOM   2313 N  N   . LYS A 1 288 ? -3.24572  40.10136 -20.26771 1.000 13.35160 ? 288  LYS A N   1 
ATOM   2314 C  CA  . LYS A 1 288 ? -3.99237  39.36718 -19.24516 1.000 13.06622 ? 288  LYS A CA  1 
ATOM   2315 C  C   . LYS A 1 288 ? -4.89722  38.31312 -19.87049 1.000 11.45239 ? 288  LYS A C   1 
ATOM   2316 O  O   . LYS A 1 288 ? -5.03322  37.20513 -19.34081 1.000 14.28154 ? 288  LYS A O   1 
ATOM   2317 C  CB  . LYS A 1 288 ? -4.82192  40.33357 -18.39374 1.000 11.39444 ? 288  LYS A CB  1 
ATOM   2318 C  CG  . LYS A 1 288 ? -3.98460  41.28238 -17.54655 1.000 14.73363 ? 288  LYS A CG  1 
ATOM   2319 C  CD  . LYS A 1 288 ? -3.15736  40.53656 -16.53358 1.000 16.36298 ? 288  LYS A CD  1 
ATOM   2320 C  CE  . LYS A 1 288 ? -3.94593  40.16768 -15.29621 1.000 18.13599 ? 288  LYS A CE  1 
ATOM   2321 N  NZ  . LYS A 1 288 ? -3.17510  39.18519 -14.47352 1.000 18.48012 ? 288  LYS A NZ  1 
ATOM   2322 N  N   . PHE A 1 289 ? -5.52785  38.64563 -20.99909 1.000 13.55476 ? 289  PHE A N   1 
ATOM   2323 C  CA  . PHE A 1 289 ? -6.42990  37.70794 -21.65802 1.000 15.17287 ? 289  PHE A CA  1 
ATOM   2324 C  C   . PHE A 1 289 ? -5.67424  36.55167 -22.29096 1.000 13.14490 ? 289  PHE A C   1 
ATOM   2325 O  O   . PHE A 1 289 ? -6.20919  35.43516 -22.36935 1.000 11.10105 ? 289  PHE A O   1 
ATOM   2326 C  CB  . PHE A 1 289 ? -7.27365  38.44694 -22.69943 1.000 12.74892 ? 289  PHE A CB  1 
ATOM   2327 C  CG  . PHE A 1 289 ? -8.13053  39.52391 -22.10158 1.000 17.51721 ? 289  PHE A CG  1 
ATOM   2328 C  CD1 . PHE A 1 289 ? -9.40553  39.23082 -21.63346 1.000 13.73806 ? 289  PHE A CD1 1 
ATOM   2329 C  CD2 . PHE A 1 289 ? -7.65032  40.82120 -21.96578 1.000 17.24580 ? 289  PHE A CD2 1 
ATOM   2330 C  CE1 . PHE A 1 289 ? -10.20619 40.21825 -21.06088 1.000 14.62647 ? 289  PHE A CE1 1 
ATOM   2331 C  CE2 . PHE A 1 289 ? -8.44324  41.81722 -21.38860 1.000 16.86220 ? 289  PHE A CE2 1 
ATOM   2332 C  CZ  . PHE A 1 289 ? -9.72768  41.50485 -20.93305 1.000 14.36031 ? 289  PHE A CZ  1 
ATOM   2333 N  N   . LEU A 1 290 ? -4.44073  36.80143 -22.74829 1.000 13.84507 ? 290  LEU A N   1 
ATOM   2334 C  CA  . LEU A 1 290 ? -3.59582  35.72291 -23.25079 1.000 13.49838 ? 290  LEU A CA  1 
ATOM   2335 C  C   . LEU A 1 290 ? -3.15807  34.80609 -22.11770 1.000 13.54673 ? 290  LEU A C   1 
ATOM   2336 O  O   . LEU A 1 290 ? -3.16919  33.57971 -22.26995 1.000 11.09755 ? 290  LEU A O   1 
ATOM   2337 C  CB  . LEU A 1 290 ? -2.36947  36.29146 -23.97860 1.000 13.37684 ? 290  LEU A CB  1 
ATOM   2338 C  CG  . LEU A 1 290 ? -2.64411  37.15628 -25.21110 1.000 14.92929 ? 290  LEU A CG  1 
ATOM   2339 C  CD1 . LEU A 1 290 ? -1.32919  37.60013 -25.88268 1.000 15.92804 ? 290  LEU A CD1 1 
ATOM   2340 C  CD2 . LEU A 1 290 ? -3.55315  36.44013 -26.20144 1.000 17.08170 ? 290  LEU A CD2 1 
ATOM   2341 N  N   . ASP A 1 291 ? -2.75844  35.38688 -20.97830 1.000 12.07396 ? 291  ASP A N   1 
ATOM   2342 C  CA  . ASP A 1 291 ? -2.43802  34.58339 -19.79974 1.000 11.85833 ? 291  ASP A CA  1 
ATOM   2343 C  C   . ASP A 1 291 ? -3.64165  33.76691 -19.33963 1.000 12.39920 ? 291  ASP A C   1 
ATOM   2344 O  O   . ASP A 1 291 ? -3.50776  32.59354 -18.97553 1.000 13.20064 ? 291  ASP A O   1 
ATOM   2345 C  CB  . ASP A 1 291 ? -1.96809  35.48201 -18.65166 1.000 13.87280 ? 291  ASP A CB  1 
ATOM   2346 C  CG  . ASP A 1 291 ? -0.75595  36.33645 -19.01668 1.000 20.43828 ? 291  ASP A CG  1 
ATOM   2347 O  OD1 . ASP A 1 291 ? -0.04915  36.00835 -19.99240 1.000 15.65391 ? 291  ASP A OD1 1 
ATOM   2348 O  OD2 . ASP A 1 291 ? -0.51480  37.33401 -18.30302 1.000 18.48006 ? 291  ASP A OD2 1 
ATOM   2349 N  N   . GLN A 1 292 ? -4.82136  34.38550 -19.30751 1.000 12.49814 ? 292  GLN A N   1 
ATOM   2350 C  CA  . GLN A 1 292 ? -6.02114  33.65024 -18.91671 1.000 9.66265  ? 292  GLN A CA  1 
ATOM   2351 C  C   . GLN A 1 292 ? -6.30397  32.51862 -19.89562 1.000 10.58251 ? 292  GLN A C   1 
ATOM   2352 O  O   . GLN A 1 292 ? -6.68194  31.41640 -19.48748 1.000 9.78418  ? 292  GLN A O   1 
ATOM   2353 C  CB  . GLN A 1 292 ? -7.21251  34.60661 -18.83376 1.000 8.51468  ? 292  GLN A CB  1 
ATOM   2354 C  CG  . GLN A 1 292 ? -8.54452  33.93589 -18.59530 1.000 8.86770  ? 292  GLN A CG  1 
ATOM   2355 C  CD  . GLN A 1 292 ? -9.67481  34.93570 -18.58458 1.000 11.56457 ? 292  GLN A CD  1 
ATOM   2356 O  OE1 . GLN A 1 292 ? -9.98408  35.55004 -19.60772 1.000 9.01341  ? 292  GLN A OE1 1 
ATOM   2357 N  NE2 . GLN A 1 292 ? -10.29507 35.11437 -17.42491 1.000 8.19842  ? 292  GLN A NE2 1 
ATOM   2358 N  N   . ALA A 1 293 ? -6.10211  32.76739 -21.19313 1.000 11.53092 ? 293  ALA A N   1 
ATOM   2359 C  CA  . ALA A 1 293 ? -6.41779  31.75186 -22.18997 1.000 10.33657 ? 293  ALA A CA  1 
ATOM   2360 C  C   . ALA A 1 293 ? -5.53288  30.52726 -22.01467 1.000 14.42995 ? 293  ALA A C   1 
ATOM   2361 O  O   . ALA A 1 293 ? -6.00938  29.38955 -22.12421 1.000 11.46552 ? 293  ALA A O   1 
ATOM   2362 C  CB  . ALA A 1 293 ? -6.27386  32.32599 -23.60172 1.000 10.99530 ? 293  ALA A CB  1 
ATOM   2363 N  N   . ALA A 1 294 ? -4.24069  30.74010 -21.72839 1.000 11.11359 ? 294  ALA A N   1 
ATOM   2364 C  CA  . ALA A 1 294 ? -3.34441  29.60984 -21.51085 1.000 12.17391 ? 294  ALA A CA  1 
ATOM   2365 C  C   . ALA A 1 294 ? -3.70876  28.85332 -20.23806 1.000 11.72643 ? 294  ALA A C   1 
ATOM   2366 O  O   . ALA A 1 294 ? -3.61780  27.62054 -20.19459 1.000 12.98934 ? 294  ALA A O   1 
ATOM   2367 C  CB  . ALA A 1 294 ? -1.89309  30.08907 -21.45994 1.000 14.01460 ? 294  ALA A CB  1 
ATOM   2368 N  N   . ARG A 1 295 ? -4.11425  29.57337 -19.18912 1.000 10.04876 ? 295  ARG A N   1 
ATOM   2369 C  CA  . ARG A 1 295 ? -4.60871  28.91295 -17.98731 1.000 9.33577  ? 295  ARG A CA  1 
ATOM   2370 C  C   . ARG A 1 295 ? -5.84084  28.06738 -18.30312 1.000 10.22761 ? 295  ARG A C   1 
ATOM   2371 O  O   . ARG A 1 295 ? -5.94692  26.91418 -17.87047 1.000 9.78892  ? 295  ARG A O   1 
ATOM   2372 C  CB  . ARG A 1 295 ? -4.91659  29.96096 -16.91376 1.000 10.83983 ? 295  ARG A CB  1 
ATOM   2373 C  CG  . ARG A 1 295 ? -5.87627  29.48958 -15.83152 1.000 9.20778  ? 295  ARG A CG  1 
ATOM   2374 C  CD  . ARG A 1 295 ? -5.24354  28.42321 -14.94658 1.000 11.48306 ? 295  ARG A CD  1 
ATOM   2375 N  NE  . ARG A 1 295 ? -5.60842  28.62708 -13.55205 1.000 11.05932 ? 295  ARG A NE  1 
ATOM   2376 C  CZ  . ARG A 1 295 ? -5.30815  27.78127 -12.57279 1.000 13.34216 ? 295  ARG A CZ  1 
ATOM   2377 N  NH1 . ARG A 1 295 ? -4.64496  26.66228 -12.83606 1.000 11.64523 ? 295  ARG A NH1 1 
ATOM   2378 N  NH2 . ARG A 1 295 ? -5.65427  28.06423 -11.32745 1.000 8.68141  ? 295  ARG A NH2 1 
ATOM   2379 N  N   . TYR A 1 296 ? -6.77388  28.61998 -19.08391 1.000 9.23255  ? 296  TYR A N   1 
ATOM   2380 C  CA  . TYR A 1 296 ? -7.97266  27.86386 -19.44710 1.000 10.39840 ? 296  TYR A CA  1 
ATOM   2381 C  C   . TYR A 1 296 ? -7.61378  26.66090 -20.30279 1.000 11.64749 ? 296  TYR A C   1 
ATOM   2382 O  O   . TYR A 1 296 ? -8.22023  25.59200 -20.17573 1.000 11.33475 ? 296  TYR A O   1 
ATOM   2383 C  CB  . TYR A 1 296 ? -8.95174  28.75988 -20.19523 1.000 8.15219  ? 296  TYR A CB  1 
ATOM   2384 C  CG  . TYR A 1 296 ? -10.08002 29.29898 -19.34371 1.000 10.02696 ? 296  TYR A CG  1 
ATOM   2385 C  CD1 . TYR A 1 296 ? -11.06543 28.45266 -18.82717 1.000 9.13993  ? 296  TYR A CD1 1 
ATOM   2386 C  CD2 . TYR A 1 296 ? -10.17092 30.65747 -19.06715 1.000 6.34243  ? 296  TYR A CD2 1 
ATOM   2387 C  CE1 . TYR A 1 296 ? -12.10996 28.95677 -18.05725 1.000 9.03831  ? 296  TYR A CE1 1 
ATOM   2388 C  CE2 . TYR A 1 296 ? -11.20307 31.16707 -18.30715 1.000 6.34395  ? 296  TYR A CE2 1 
ATOM   2389 C  CZ  . TYR A 1 296 ? -12.17600 30.32084 -17.81223 1.000 11.19618 ? 296  TYR A CZ  1 
ATOM   2390 O  OH  . TYR A 1 296 ? -13.19624 30.84003 -17.04407 1.000 8.54261  ? 296  TYR A OH  1 
ATOM   2391 N  N   . ASP A 1 297 ? -6.63689  26.82995 -21.19590 1.000 9.61276  ? 297  ASP A N   1 
ATOM   2392 C  CA  . ASP A 1 297 ? -6.14393  25.71980 -22.00191 1.000 10.91208 ? 297  ASP A CA  1 
ATOM   2393 C  C   . ASP A 1 297 ? -5.70448  24.55345 -21.12257 1.000 10.63007 ? 297  ASP A C   1 
ATOM   2394 O  O   . ASP A 1 297 ? -6.16597  23.41981 -21.29894 1.000 11.23870 ? 297  ASP A O   1 
ATOM   2395 C  CB  . ASP A 1 297 ? -4.98547  26.20806 -22.87822 1.000 13.76897 ? 297  ASP A CB  1 
ATOM   2396 C  CG  . ASP A 1 297 ? -4.41043  25.10957 -23.76011 1.000 16.51301 ? 297  ASP A CG  1 
ATOM   2397 O  OD1 . ASP A 1 297 ? -5.19175  24.36885 -24.37513 1.000 16.97687 ? 297  ASP A OD1 1 
ATOM   2398 O  OD2 . ASP A 1 297 ? -3.17637  24.99400 -23.84014 1.000 21.17882 ? 297  ASP A OD2 1 
ATOM   2399 N  N   . ARG A 1 298 ? -4.81775  24.82441 -20.15967 1.000 8.24286  ? 298  ARG A N   1 
ATOM   2400 C  CA  . ARG A 1 298 ? -4.32357  23.78887 -19.25639 1.000 12.85224 ? 298  ARG A CA  1 
ATOM   2401 C  C   . ARG A 1 298 ? -5.44114  23.23940 -18.38606 1.000 10.25554 ? 298  ARG A C   1 
ATOM   2402 O  O   . ARG A 1 298 ? -5.48695  22.03800 -18.09915 1.000 10.97189 ? 298  ARG A O   1 
ATOM   2403 C  CB  . ARG A 1 298 ? -3.20191  24.34974 -18.37233 1.000 13.99495 ? 298  ARG A CB  1 
ATOM   2404 C  CG  . ARG A 1 298 ? -1.98347  24.85729 -19.14041 1.000 19.85529 ? 298  ARG A CG  1 
ATOM   2405 C  CD  . ARG A 1 298 ? -0.81233  25.19557 -18.18821 1.000 17.75964 ? 298  ARG A CD  1 
ATOM   2406 N  NE  . ARG A 1 298 ? -1.17091  26.22340 -17.20646 1.000 15.11783 ? 298  ARG A NE  1 
ATOM   2407 C  CZ  . ARG A 1 298 ? -1.08386  27.53141 -17.42793 1.000 21.09345 ? 298  ARG A CZ  1 
ATOM   2408 N  NH1 . ARG A 1 298 ? -0.65172  27.97894 -18.60474 1.000 12.96778 ? 298  ARG A NH1 1 
ATOM   2409 N  NH2 . ARG A 1 298 ? -1.43727  28.39584 -16.47828 1.000 22.19901 ? 298  ARG A NH2 1 
ATOM   2410 N  N   . LEU A 1 299 ? -6.35413  24.10768 -17.96119 1.000 9.59660  ? 299  LEU A N   1 
ATOM   2411 C  CA  . LEU A 1 299 ? -7.39492  23.69535 -17.02865 1.000 11.19519 ? 299  LEU A CA  1 
ATOM   2412 C  C   . LEU A 1 299 ? -8.34328  22.68986 -17.66844 1.000 9.67635  ? 299  LEU A C   1 
ATOM   2413 O  O   . LEU A 1 299 ? -8.66609  21.65730 -17.07091 1.000 7.38996  ? 299  LEU A O   1 
ATOM   2414 C  CB  . LEU A 1 299 ? -8.15913  24.92909 -16.53293 1.000 9.48182  ? 299  LEU A CB  1 
ATOM   2415 C  CG  . LEU A 1 299 ? -9.19814  24.62686 -15.45715 1.000 14.37767 ? 299  LEU A CG  1 
ATOM   2416 C  CD1 . LEU A 1 299 ? -8.51697  24.25754 -14.12251 1.000 12.66907 ? 299  LEU A CD1 1 
ATOM   2417 C  CD2 . LEU A 1 299 ? -10.13757 25.82163 -15.28568 1.000 12.62105 ? 299  LEU A CD2 1 
ATOM   2418 N  N   . PHE A 1 300 ? -8.81008  22.97810 -18.88273 1.000 8.72806  ? 300  PHE A N   1 
ATOM   2419 C  CA  . PHE A 1 300 ? -9.78777  22.09600 -19.50547 1.000 7.79541  ? 300  PHE A CA  1 
ATOM   2420 C  C   . PHE A 1 300 ? -9.13735  20.83954 -20.07867 1.000 10.68656 ? 300  PHE A C   1 
ATOM   2421 O  O   . PHE A 1 300 ? -9.78860  19.79243 -20.17046 1.000 10.68153 ? 300  PHE A O   1 
ATOM   2422 C  CB  . PHE A 1 300 ? -10.58025 22.86603 -20.56831 1.000 8.59793  ? 300  PHE A CB  1 
ATOM   2423 C  CG  . PHE A 1 300 ? -11.85325 23.48329 -20.01390 1.000 9.73575  ? 300  PHE A CG  1 
ATOM   2424 C  CD1 . PHE A 1 300 ? -11.79454 24.64004 -19.24234 1.000 9.07660  ? 300  PHE A CD1 1 
ATOM   2425 C  CD2 . PHE A 1 300 ? -13.08688 22.85927 -20.19468 1.000 8.63655  ? 300  PHE A CD2 1 
ATOM   2426 C  CE1 . PHE A 1 300 ? -12.95820 25.19005 -18.66962 1.000 6.48363  ? 300  PHE A CE1 1 
ATOM   2427 C  CE2 . PHE A 1 300 ? -14.25488 23.40582 -19.63908 1.000 9.21029  ? 300  PHE A CE2 1 
ATOM   2428 C  CZ  . PHE A 1 300 ? -14.18029 24.57983 -18.88195 1.000 8.23771  ? 300  PHE A CZ  1 
ATOM   2429 N  N   . LYS A 1 301 ? -7.86172  20.91584 -20.45099 1.000 10.50588 ? 301  LYS A N   1 
ATOM   2430 C  CA  . LYS A 1 301 ? -7.12305  19.70175 -20.77861 1.000 12.53133 ? 301  LYS A CA  1 
ATOM   2431 C  C   . LYS A 1 301 ? -7.07640  18.76293 -19.57636 1.000 10.97075 ? 301  LYS A C   1 
ATOM   2432 O  O   . LYS A 1 301 ? -7.26557  17.54729 -19.71303 1.000 11.73571 ? 301  LYS A O   1 
ATOM   2433 C  CB  . LYS A 1 301 ? -5.71115  20.07482 -21.24660 1.000 11.21618 ? 301  LYS A CB  1 
ATOM   2434 C  CG  . LYS A 1 301 ? -5.15960  19.18898 -22.33621 1.000 26.34149 ? 301  LYS A CG  1 
ATOM   2435 C  CD  . LYS A 1 301 ? -4.00810  19.87402 -23.06745 1.000 32.09817 ? 301  LYS A CD  1 
ATOM   2436 C  CE  . LYS A 1 301 ? -4.35934  21.31125 -23.45687 1.000 27.17382 ? 301  LYS A CE  1 
ATOM   2437 N  NZ  . LYS A 1 301 ? -3.29135  21.97736 -24.27774 1.000 28.45976 ? 301  LYS A NZ  1 
ATOM   2438 N  N   . LEU A 1 302 ? -6.87740  19.32161 -18.38122 1.000 9.23195  ? 302  LEU A N   1 
ATOM   2439 C  CA  . LEU A 1 302 ? -6.88514  18.51063 -17.16789 1.000 10.24670 ? 302  LEU A CA  1 
ATOM   2440 C  C   . LEU A 1 302 ? -8.28642  17.98521 -16.85851 1.000 11.72107 ? 302  LEU A C   1 
ATOM   2441 O  O   . LEU A 1 302 ? -8.44552  16.81836 -16.47341 1.000 11.25272 ? 302  LEU A O   1 
ATOM   2442 C  CB  . LEU A 1 302 ? -6.32704  19.31334 -15.98907 1.000 8.19766  ? 302  LEU A CB  1 
ATOM   2443 C  CG  . LEU A 1 302 ? -6.44314  18.63351 -14.61463 1.000 12.63873 ? 302  LEU A CG  1 
ATOM   2444 C  CD1 . LEU A 1 302 ? -5.54325  17.40067 -14.53003 1.000 10.86986 ? 302  LEU A CD1 1 
ATOM   2445 C  CD2 . LEU A 1 302 ? -6.15584  19.59714 -13.45588 1.000 12.11099 ? 302  LEU A CD2 1 
ATOM   2446 N  N   . TYR A 1 303 ? -9.31851  18.81409 -17.02798 1.000 9.47818  ? 303  TYR A N   1 
ATOM   2447 C  CA  . TYR A 1 303 ? -10.67578 18.31095 -16.81915 1.000 9.14152  ? 303  TYR A CA  1 
ATOM   2448 C  C   . TYR A 1 303 ? -10.96125 17.13356 -17.74462 1.000 10.19596 ? 303  TYR A C   1 
ATOM   2449 O  O   . TYR A 1 303 ? -11.53133 16.12220 -17.31706 1.000 9.24669  ? 303  TYR A O   1 
ATOM   2450 C  CB  . TYR A 1 303 ? -11.71038 19.42183 -17.04409 1.000 9.53148  ? 303  TYR A CB  1 
ATOM   2451 C  CG  . TYR A 1 303 ? -11.72721 20.50217 -15.98231 1.000 9.49635  ? 303  TYR A CG  1 
ATOM   2452 C  CD1 . TYR A 1 303 ? -11.24150 20.26532 -14.70025 1.000 10.45426 ? 303  TYR A CD1 1 
ATOM   2453 C  CD2 . TYR A 1 303 ? -12.24342 21.75713 -16.26204 1.000 10.66531 ? 303  TYR A CD2 1 
ATOM   2454 C  CE1 . TYR A 1 303 ? -11.25946 21.26613 -13.71803 1.000 11.14251 ? 303  TYR A CE1 1 
ATOM   2455 C  CE2 . TYR A 1 303 ? -12.26520 22.75779 -15.30089 1.000 11.23546 ? 303  TYR A CE2 1 
ATOM   2456 C  CZ  . TYR A 1 303 ? -11.77577 22.50961 -14.03256 1.000 13.89926 ? 303  TYR A CZ  1 
ATOM   2457 O  OH  . TYR A 1 303 ? -11.81155 23.51534 -13.09592 1.000 11.96073 ? 303  TYR A OH  1 
ATOM   2458 N  N   . GLU A 1 304 ? -10.54688 17.23971 -19.01448 1.000 8.39667  ? 304  GLU A N   1 
ATOM   2459 C  CA  . GLU A 1 304 ? -10.76787 16.14991 -19.96003 1.000 11.15946 ? 304  GLU A CA  1 
ATOM   2460 C  C   . GLU A 1 304 ? -10.00005 14.90237 -19.55577 1.000 11.21477 ? 304  GLU A C   1 
ATOM   2461 O  O   . GLU A 1 304 ? -10.53769 13.79090 -19.62072 1.000 12.99506 ? 304  GLU A O   1 
ATOM   2462 C  CB  . GLU A 1 304 ? -10.37459 16.58019 -21.36800 1.000 12.76989 ? 304  GLU A CB  1 
ATOM   2463 C  CG  . GLU A 1 304 ? -11.36808 17.53666 -21.98544 1.000 14.82274 ? 304  GLU A CG  1 
ATOM   2464 C  CD  . GLU A 1 304 ? -11.27752 17.55108 -23.49748 1.000 18.95594 ? 304  GLU A CD  1 
ATOM   2465 O  OE1 . GLU A 1 304 ? -10.40652 18.26533 -24.01681 1.000 14.66306 ? 304  GLU A OE1 1 
ATOM   2466 O  OE2 . GLU A 1 304 ? -12.06973 16.84519 -24.15467 1.000 15.22202 ? 304  GLU A OE2 1 
ATOM   2467 N  N   . LYS A 1 305 ? -8.74045  15.06597 -19.13786 1.000 11.84053 ? 305  LYS A N   1 
ATOM   2468 C  CA  . LYS A 1 305 ? -7.97864  13.93641 -18.60942 1.000 12.04230 ? 305  LYS A CA  1 
ATOM   2469 C  C   . LYS A 1 305 ? -8.73820  13.23921 -17.48687 1.000 14.69129 ? 305  LYS A C   1 
ATOM   2470 O  O   . LYS A 1 305 ? -8.73118  12.00874 -17.39151 1.000 13.45142 ? 305  LYS A O   1 
ATOM   2471 C  CB  . LYS A 1 305 ? -6.61619  14.41260 -18.10544 1.000 11.95302 ? 305  LYS A CB  1 
ATOM   2472 C  CG  . LYS A 1 305 ? -5.66825  13.29610 -17.64945 1.000 18.33434 ? 305  LYS A CG  1 
ATOM   2473 C  CD  . LYS A 1 305 ? -4.48923  13.87839 -16.85917 1.000 19.53033 ? 305  LYS A CD  1 
ATOM   2474 C  CE  . LYS A 1 305 ? -3.39757  12.84879 -16.55707 1.000 23.64775 ? 305  LYS A CE  1 
ATOM   2475 N  NZ  . LYS A 1 305 ? -2.28623  13.46192 -15.74113 1.000 22.88972 ? 305  LYS A NZ  1 
ATOM   2476 N  N   . LEU A 1 306 ? -9.40686  14.01412 -16.62943 1.000 14.23534 ? 306  LEU A N   1 
ATOM   2477 C  CA  . LEU A 1 306 ? -10.14040 13.47910 -15.49086 1.000 13.32597 ? 306  LEU A CA  1 
ATOM   2478 C  C   . LEU A 1 306 ? -11.62045 13.30251 -15.78135 1.000 13.81335 ? 306  LEU A C   1 
ATOM   2479 O  O   . LEU A 1 306 ? -12.42868 13.25912 -14.84207 1.000 11.14715 ? 306  LEU A O   1 
ATOM   2480 C  CB  . LEU A 1 306 ? -9.96006  14.38672 -14.27812 1.000 12.57443 ? 306  LEU A CB  1 
ATOM   2481 C  CG  . LEU A 1 306 ? -8.52161  14.65088 -13.82411 1.000 17.21814 ? 306  LEU A CG  1 
ATOM   2482 C  CD1 . LEU A 1 306 ? -8.49425  15.71019 -12.71645 1.000 11.92940 ? 306  LEU A CD1 1 
ATOM   2483 C  CD2 . LEU A 1 306 ? -7.85866  13.35984 -13.36558 1.000 19.99738 ? 306  LEU A CD2 1 
ATOM   2484 N  N   . SER A 1 307 ? -12.00142 13.19698 -17.05800 1.000 11.23458 ? 307  SER A N   1 
ATOM   2485 C  CA  . SER A 1 307 ? -13.42750 13.25238 -17.36646 1.000 13.29655 ? 307  SER A CA  1 
ATOM   2486 C  C   . SER A 1 307 ? -14.18911 12.07653 -16.77856 1.000 13.87261 ? 307  SER A C   1 
ATOM   2487 O  O   . SER A 1 307 ? -15.39699 12.18492 -16.57059 1.000 12.88686 ? 307  SER A O   1 
ATOM   2488 C  CB  . SER A 1 307 ? -13.66255 13.32003 -18.87227 1.000 12.23092 ? 307  SER A CB  1 
ATOM   2489 O  OG  . SER A 1 307 ? -13.21496 12.14180 -19.51545 1.000 15.29873 ? 307  SER A OG  1 
ATOM   2490 N  N   . ASP A 1 308 ? -13.52024 10.96857 -16.46922 1.000 11.63834 ? 308  ASP A N   1 
ATOM   2491 C  CA  . ASP A 1 308 ? -14.27174 9.87947  -15.86285 1.000 15.74133 ? 308  ASP A CA  1 
ATOM   2492 C  C   . ASP A 1 308 ? -14.59932 10.15484 -14.40064 1.000 15.20992 ? 308  ASP A C   1 
ATOM   2493 O  O   . ASP A 1 308 ? -15.36929 9.39811  -13.80015 1.000 18.27008 ? 308  ASP A O   1 
ATOM   2494 C  CB  . ASP A 1 308 ? -13.51014 8.55472  -16.02096 1.000 17.37324 ? 308  ASP A CB  1 
ATOM   2495 C  CG  . ASP A 1 308 ? -12.09262 8.62397  -15.51229 1.000 21.29445 ? 308  ASP A CG  1 
ATOM   2496 O  OD1 . ASP A 1 308 ? -11.45551 9.70289  -15.59131 1.000 29.71389 ? 308  ASP A OD1 1 
ATOM   2497 O  OD2 . ASP A 1 308 ? -11.59768 7.58600  -15.03797 1.000 34.14084 ? 308  ASP A OD2 1 
ATOM   2498 N  N   . LYS A 1 309 ? -14.07471 11.24058 -13.82924 1.000 10.83248 ? 309  LYS A N   1 
ATOM   2499 C  CA  . LYS A 1 309 ? -14.32923 11.59389 -12.43982 1.000 13.02338 ? 309  LYS A CA  1 
ATOM   2500 C  C   . LYS A 1 309 ? -15.09000 12.90981 -12.28286 1.000 11.29260 ? 309  LYS A C   1 
ATOM   2501 O  O   . LYS A 1 309 ? -15.34894 13.33204 -11.14777 1.000 12.41829 ? 309  LYS A O   1 
ATOM   2502 C  CB  . LYS A 1 309 ? -13.00309 11.66667 -11.66626 1.000 12.54153 ? 309  LYS A CB  1 
ATOM   2503 C  CG  . LYS A 1 309 ? -12.17874 10.37633 -11.73137 1.000 16.56488 ? 309  LYS A CG  1 
ATOM   2504 C  CD  . LYS A 1 309 ? -10.69353 10.62443 -11.46781 1.000 18.17414 ? 309  LYS A CD  1 
ATOM   2505 C  CE  . LYS A 1 309 ? -9.89853  9.30506  -11.50673 1.000 25.24035 ? 309  LYS A CE  1 
ATOM   2506 N  NZ  . LYS A 1 309 ? -8.45396  9.51153  -11.85928 1.000 26.54368 ? 309  LYS A NZ  1 
ATOM   2507 N  N   . ILE A 1 310 ? -15.47370 13.55098 -13.37977 1.000 10.46934 ? 310  ILE A N   1 
ATOM   2508 C  CA  . ILE A 1 310 ? -16.13283 14.85494 -13.36980 1.000 12.85309 ? 310  ILE A CA  1 
ATOM   2509 C  C   . ILE A 1 310 ? -17.37358 14.76893 -14.24625 1.000 10.01161 ? 310  ILE A C   1 
ATOM   2510 O  O   . ILE A 1 310 ? -17.25954 14.52625 -15.44788 1.000 11.35638 ? 310  ILE A O   1 
ATOM   2511 C  CB  . ILE A 1 310 ? -15.19778 15.96246 -13.88649 1.000 12.11045 ? 310  ILE A CB  1 
ATOM   2512 C  CG1 . ILE A 1 310 ? -13.98393 16.11711 -12.96420 1.000 10.52312 ? 310  ILE A CG1 1 
ATOM   2513 C  CG2 . ILE A 1 310 ? -15.96645 17.28165 -14.05387 1.000 10.30650 ? 310  ILE A CG2 1 
ATOM   2514 C  CD1 . ILE A 1 310 ? -12.89131 16.99947 -13.55826 1.000 11.31006 ? 310  ILE A CD1 1 
ATOM   2515 N  N   . SER A 1 311 ? -18.55029 14.99021 -13.66442 1.000 10.67615 ? 311  SER A N   1 
ATOM   2516 C  CA  . SER A 1 311 ? -19.78169 14.93596 -14.45478 1.000 10.46884 ? 311  SER A CA  1 
ATOM   2517 C  C   . SER A 1 311 ? -20.23777 16.29558 -14.99484 1.000 9.43751  ? 311  SER A C   1 
ATOM   2518 O  O   . SER A 1 311 ? -21.05789 16.32995 -15.91946 1.000 7.56612  ? 311  SER A O   1 
ATOM   2519 C  CB  . SER A 1 311 ? -20.91892 14.32386 -13.62666 1.000 10.06256 ? 311  SER A CB  1 
ATOM   2520 O  OG  . SER A 1 311 ? -21.18893 15.12334 -12.47843 1.000 10.81012 ? 311  SER A OG  1 
ATOM   2521 N  N   . ASN A 1 312 ? -19.71802 17.40844 -14.47427 1.000 8.78817  ? 312  ASN A N   1 
ATOM   2522 C  CA  . ASN A 1 312 ? -20.22377 18.72610 -14.85330 1.000 8.03063  ? 312  ASN A CA  1 
ATOM   2523 C  C   . ASN A 1 312 ? -19.16750 19.77509 -14.55436 1.000 6.99819  ? 312  ASN A C   1 
ATOM   2524 O  O   . ASN A 1 312 ? -18.46775 19.69469 -13.53796 1.000 7.17895  ? 312  ASN A O   1 
ATOM   2525 C  CB  . ASN A 1 312 ? -21.52966 19.05679 -14.10260 1.000 5.99981  ? 312  ASN A CB  1 
ATOM   2526 C  CG  . ASN A 1 312 ? -21.88020 20.54300 -14.12439 1.000 9.79266  ? 312  ASN A CG  1 
ATOM   2527 O  OD1 . ASN A 1 312 ? -21.65550 21.26195 -13.14373 1.000 9.58769  ? 312  ASN A OD1 1 
ATOM   2528 N  ND2 . ASN A 1 312 ? -22.46406 21.00403 -15.23257 1.000 7.70129  ? 312  ASN A ND2 1 
ATOM   2529 N  N   . VAL A 1 313 ? -19.06119 20.75031 -15.44886 1.000 6.37543  ? 313  VAL A N   1 
ATOM   2530 C  CA  . VAL A 1 313 ? -18.27796 21.96529 -15.22516 1.000 6.40232  ? 313  VAL A CA  1 
ATOM   2531 C  C   . VAL A 1 313 ? -19.22085 23.14411 -15.45423 1.000 6.21056  ? 313  VAL A C   1 
ATOM   2532 O  O   . VAL A 1 313 ? -19.70076 23.35303 -16.57290 1.000 5.76143  ? 313  VAL A O   1 
ATOM   2533 C  CB  . VAL A 1 313 ? -17.05153 22.04719 -16.14577 1.000 7.98747  ? 313  VAL A CB  1 
ATOM   2534 C  CG1 . VAL A 1 313 ? -16.34027 23.39439 -15.98762 1.000 5.60809  ? 313  VAL A CG1 1 
ATOM   2535 C  CG2 . VAL A 1 313 ? -16.09959 20.89067 -15.88036 1.000 5.61883  ? 313  VAL A CG2 1 
ATOM   2536 N  N   . THR A 1 314 ? -19.49547 23.90301 -14.40308 1.000 4.64450  ? 314  THR A N   1 
ATOM   2537 C  CA  . THR A 1 314 ? -20.38164 25.05340 -14.46775 1.000 5.66542  ? 314  THR A CA  1 
ATOM   2538 C  C   . THR A 1 314 ? -19.57737 26.31891 -14.21121 1.000 7.04826  ? 314  THR A C   1 
ATOM   2539 O  O   . THR A 1 314 ? -18.82241 26.38640 -13.23137 1.000 6.97161  ? 314  THR A O   1 
ATOM   2540 C  CB  . THR A 1 314 ? -21.50707 24.93860 -13.43334 1.000 6.85876  ? 314  THR A CB  1 
ATOM   2541 O  OG1 . THR A 1 314 ? -22.30286 23.77158 -13.70496 1.000 6.48292  ? 314  THR A OG1 1 
ATOM   2542 C  CG2 . THR A 1 314 ? -22.39327 26.19755 -13.47108 1.000 5.27193  ? 314  THR A CG2 1 
ATOM   2543 N  N   . PHE A 1 315 ? -19.73633 27.30753 -15.09411 1.000 7.56096  ? 315  PHE A N   1 
ATOM   2544 C  CA  . PHE A 1 315 ? -19.18506 28.64344 -14.88024 1.000 5.92937  ? 315  PHE A CA  1 
ATOM   2545 C  C   . PHE A 1 315 ? -20.16249 29.44731 -14.03647 1.000 8.93557  ? 315  PHE A C   1 
ATOM   2546 O  O   . PHE A 1 315 ? -21.37499 29.35430 -14.23011 1.000 6.57641  ? 315  PHE A O   1 
ATOM   2547 C  CB  . PHE A 1 315 ? -18.97744 29.38324 -16.20931 1.000 6.10173  ? 315  PHE A CB  1 
ATOM   2548 C  CG  . PHE A 1 315 ? -17.95458 28.75765 -17.12613 1.000 8.25096  ? 315  PHE A CG  1 
ATOM   2549 C  CD1 . PHE A 1 315 ? -16.61687 29.10598 -17.03112 1.000 6.97632  ? 315  PHE A CD1 1 
ATOM   2550 C  CD2 . PHE A 1 315 ? -18.33651 27.83824 -18.09918 1.000 9.03150  ? 315  PHE A CD2 1 
ATOM   2551 C  CE1 . PHE A 1 315 ? -15.67499 28.55669 -17.89052 1.000 7.93153  ? 315  PHE A CE1 1 
ATOM   2552 C  CE2 . PHE A 1 315 ? -17.39190 27.28043 -18.96535 1.000 6.94663  ? 315  PHE A CE2 1 
ATOM   2553 C  CZ  . PHE A 1 315 ? -16.05639 27.64987 -18.85263 1.000 6.34133  ? 315  PHE A CZ  1 
ATOM   2554 N  N   . TRP A 1 316 ? -19.64222 30.25969 -13.11254 1.000 6.79357  ? 316  TRP A N   1 
ATOM   2555 C  CA  . TRP A 1 316 ? -20.51910 31.09309 -12.29156 1.000 6.23244  ? 316  TRP A CA  1 
ATOM   2556 C  C   . TRP A 1 316 ? -20.90625 32.37077 -13.04819 1.000 6.45573  ? 316  TRP A C   1 
ATOM   2557 O  O   . TRP A 1 316 ? -20.65326 33.49160 -12.60832 1.000 7.15720  ? 316  TRP A O   1 
ATOM   2558 C  CB  . TRP A 1 316 ? -19.86929 31.42002 -10.95171 1.000 9.14746  ? 316  TRP A CB  1 
ATOM   2559 C  CG  . TRP A 1 316 ? -20.91649 31.68601 -9.88687  1.000 8.98838  ? 316  TRP A CG  1 
ATOM   2560 C  CD1 . TRP A 1 316 ? -21.18666 32.88122 -9.27981  1.000 10.70263 ? 316  TRP A CD1 1 
ATOM   2561 C  CD2 . TRP A 1 316 ? -21.85865 30.74080 -9.34675  1.000 8.42929  ? 316  TRP A CD2 1 
ATOM   2562 N  NE1 . TRP A 1 316 ? -22.21733 32.73746 -8.38411  1.000 10.20410 ? 316  TRP A NE1 1 
ATOM   2563 C  CE2 . TRP A 1 316 ? -22.65174 31.43621 -8.40320  1.000 12.67204 ? 316  TRP A CE2 1 
ATOM   2564 C  CE3 . TRP A 1 316 ? -22.09311 29.37026 -9.55197  1.000 9.92469  ? 316  TRP A CE3 1 
ATOM   2565 C  CZ2 . TRP A 1 316 ? -23.66996 30.80758 -7.66623  1.000 12.99784 ? 316  TRP A CZ2 1 
ATOM   2566 C  CZ3 . TRP A 1 316 ? -23.10977 28.74521 -8.82702  1.000 10.08877 ? 316  TRP A CZ3 1 
ATOM   2567 C  CH2 . TRP A 1 316 ? -23.88522 29.46549 -7.89246  1.000 11.22223 ? 316  TRP A CH2 1 
ATOM   2568 N  N   . GLY A 1 317 ? -21.53228 32.17012 -14.20188 1.000 4.53041  ? 317  GLY A N   1 
ATOM   2569 C  CA  . GLY A 1 317 ? -22.03194 33.25555 -15.02534 1.000 5.73509  ? 317  GLY A CA  1 
ATOM   2570 C  C   . GLY A 1 317 ? -22.03707 32.85132 -16.48923 1.000 9.78801  ? 317  GLY A C   1 
ATOM   2571 O  O   . GLY A 1 317 ? -21.71073 31.72241 -16.85185 1.000 6.72788  ? 317  GLY A O   1 
ATOM   2572 N  N   . ILE A 1 318 ? -22.41287 33.81611 -17.33291 1.000 8.01408  ? 318  ILE A N   1 
ATOM   2573 C  CA  . ILE A 1 318 ? -22.55192 33.60746 -18.78071 1.000 6.97443  ? 318  ILE A CA  1 
ATOM   2574 C  C   . ILE A 1 318 ? -21.45053 34.32636 -19.54247 1.000 8.58079  ? 318  ILE A C   1 
ATOM   2575 O  O   . ILE A 1 318 ? -20.64693 33.69844 -20.23489 1.000 7.65230  ? 318  ILE A O   1 
ATOM   2576 C  CB  . ILE A 1 318 ? -23.94808 34.06081 -19.26925 1.000 6.99294  ? 318  ILE A CB  1 
ATOM   2577 C  CG1 . ILE A 1 318 ? -25.04157 33.41873 -18.41372 1.000 6.11676  ? 318  ILE A CG1 1 
ATOM   2578 C  CG2 . ILE A 1 318 ? -24.12765 33.77964 -20.77389 1.000 8.05806  ? 318  ILE A CG2 1 
ATOM   2579 C  CD1 . ILE A 1 318 ? -26.48317 33.87443 -18.78774 1.000 8.22534  ? 318  ILE A CD1 1 
ATOM   2580 N  N   . ALA A 1 319 ? -21.40650 35.65304 -19.44667 1.000 7.13227  ? 319  ALA A N   1 
ATOM   2581 C  CA  . ALA A 1 319 ? -20.39319 36.42420 -20.15168 1.000 6.50965  ? 319  ALA A CA  1 
ATOM   2582 C  C   . ALA A 1 319 ? -19.87547 37.51570 -19.22818 1.000 6.39812  ? 319  ALA A C   1 
ATOM   2583 O  O   . ALA A 1 319 ? -20.48084 37.82610 -18.20077 1.000 6.84970  ? 319  ALA A O   1 
ATOM   2584 C  CB  . ALA A 1 319 ? -20.93666 37.01004 -21.46187 1.000 6.38722  ? 319  ALA A CB  1 
ATOM   2585 N  N   . ASP A 1 320 ? -18.73990 38.10371 -19.61360 1.000 8.38763  ? 320  ASP A N   1 
ATOM   2586 C  CA  . ASP A 1 320 ? -17.96987 38.96770 -18.72276 1.000 9.82012  ? 320  ASP A CA  1 
ATOM   2587 C  C   . ASP A 1 320 ? -18.73043 40.21276 -18.26686 1.000 11.98412 ? 320  ASP A C   1 
ATOM   2588 O  O   . ASP A 1 320 ? -18.27580 40.87144 -17.32038 1.000 9.75626  ? 320  ASP A O   1 
ATOM   2589 C  CB  . ASP A 1 320 ? -16.65180 39.38549 -19.40983 1.000 8.79299  ? 320  ASP A CB  1 
ATOM   2590 C  CG  . ASP A 1 320 ? -15.54349 38.33229 -19.26350 1.000 9.95663  ? 320  ASP A CG  1 
ATOM   2591 O  OD1 . ASP A 1 320 ? -15.76123 37.31334 -18.55757 1.000 7.21091  ? 320  ASP A OD1 1 
ATOM   2592 O  OD2 . ASP A 1 320 ? -14.43854 38.53915 -19.84535 1.000 9.20692  ? 320  ASP A OD2 1 
ATOM   2593 N  N   . ASN A 1 321 ? -19.86207 40.55674 -18.90114 1.000 8.44881  ? 321  ASN A N   1 
ATOM   2594 C  CA  . ASN A 1 321 ? -20.62857 41.71995 -18.45093 1.000 10.59394 ? 321  ASN A CA  1 
ATOM   2595 C  C   . ASN A 1 321 ? -21.28902 41.51764 -17.08945 1.000 14.51877 ? 321  ASN A C   1 
ATOM   2596 O  O   . ASN A 1 321 ? -21.72362 42.50194 -16.49166 1.000 12.00191 ? 321  ASN A O   1 
ATOM   2597 C  CB  . ASN A 1 321 ? -21.71361 42.09815 -19.47592 1.000 9.34773  ? 321  ASN A CB  1 
ATOM   2598 C  CG  . ASN A 1 321 ? -22.66817 40.94322 -19.76687 1.000 10.78972 ? 321  ASN A CG  1 
ATOM   2599 O  OD1 . ASN A 1 321 ? -22.25063 39.79592 -19.83925 1.000 9.29321  ? 321  ASN A OD1 1 
ATOM   2600 N  ND2 . ASN A 1 321 ? -23.94809 41.24822 -19.93351 1.000 10.68072 ? 321  ASN A ND2 1 
ATOM   2601 N  N   . HIS A 1 322 ? -21.37275 40.29079 -16.57566 1.000 9.35568  ? 322  HIS A N   1 
ATOM   2602 C  CA  . HIS A 1 322 ? -22.04862 40.05411 -15.30481 1.000 9.12420  ? 322  HIS A CA  1 
ATOM   2603 C  C   . HIS A 1 322 ? -21.30232 38.95645 -14.55117 1.000 10.89497 ? 322  HIS A C   1 
ATOM   2604 O  O   . HIS A 1 322 ? -21.30078 37.79379 -14.97224 1.000 7.89944  ? 322  HIS A O   1 
ATOM   2605 C  CB  . HIS A 1 322 ? -23.52264 39.68540 -15.51701 1.000 12.27291 ? 322  HIS A CB  1 
ATOM   2606 C  CG  . HIS A 1 322 ? -24.27427 39.48255 -14.23707 1.000 16.84239 ? 322  HIS A CG  1 
ATOM   2607 N  ND1 . HIS A 1 322 ? -25.21270 40.37752 -13.77397 1.000 18.50221 ? 322  HIS A ND1 1 
ATOM   2608 C  CD2 . HIS A 1 322 ? -24.18886 38.50807 -13.29858 1.000 15.50961 ? 322  HIS A CD2 1 
ATOM   2609 C  CE1 . HIS A 1 322 ? -25.68409 39.95621 -12.61153 1.000 19.10034 ? 322  HIS A CE1 1 
ATOM   2610 N  NE2 . HIS A 1 322 ? -25.08145 38.82171 -12.30386 1.000 13.46289 ? 322  HIS A NE2 1 
ATOM   2611 N  N   . THR A 1 323 ? -20.66912 39.32070 -13.43767 1.000 9.06117  ? 323  THR A N   1 
ATOM   2612 C  CA  . THR A 1 323 ? -19.96906 38.34735 -12.60945 1.000 8.76803  ? 323  THR A CA  1 
ATOM   2613 C  C   . THR A 1 323 ? -19.91869 38.86955 -11.18439 1.000 11.25079 ? 323  THR A C   1 
ATOM   2614 O  O   . THR A 1 323 ? -19.59590 40.04340 -10.96141 1.000 8.57961  ? 323  THR A O   1 
ATOM   2615 C  CB  . THR A 1 323 ? -18.53840 38.08157 -13.10587 1.000 8.73440  ? 323  THR A CB  1 
ATOM   2616 O  OG1 . THR A 1 323 ? -17.79648 37.39047 -12.08714 1.000 5.99753  ? 323  THR A OG1 1 
ATOM   2617 C  CG2 . THR A 1 323 ? -17.82084 39.41513 -13.44631 1.000 7.08311  ? 323  THR A CG2 1 
ATOM   2618 N  N   . TRP A 1 324 ? -20.21214 37.98360 -10.22598 1.000 8.24999  ? 324  TRP A N   1 
ATOM   2619 C  CA  . TRP A 1 324 ? -20.08946 38.32335 -8.81154  1.000 10.92388 ? 324  TRP A CA  1 
ATOM   2620 C  C   . TRP A 1 324 ? -18.66809 38.74696 -8.43706  1.000 10.42645 ? 324  TRP A C   1 
ATOM   2621 O  O   . TRP A 1 324 ? -18.47310 39.39599 -7.40146  1.000 9.20750  ? 324  TRP A O   1 
ATOM   2622 C  CB  . TRP A 1 324 ? -20.52711 37.13662 -7.94553  1.000 10.61920 ? 324  TRP A CB  1 
ATOM   2623 C  CG  . TRP A 1 324 ? -19.43664 36.11041 -7.73433  1.000 14.23146 ? 324  TRP A CG  1 
ATOM   2624 C  CD1 . TRP A 1 324 ? -18.85692 35.31550 -8.68963  1.000 11.83832 ? 324  TRP A CD1 1 
ATOM   2625 C  CD2 . TRP A 1 324 ? -18.78162 35.79215 -6.49887  1.000 11.57615 ? 324  TRP A CD2 1 
ATOM   2626 N  NE1 . TRP A 1 324 ? -17.89069 34.51969 -8.11603  1.000 12.99176 ? 324  TRP A NE1 1 
ATOM   2627 C  CE2 . TRP A 1 324 ? -17.82439 34.79537 -6.77594  1.000 10.72678 ? 324  TRP A CE2 1 
ATOM   2628 C  CE3 . TRP A 1 324 ? -18.91894 36.24720 -5.18515  1.000 12.58908 ? 324  TRP A CE3 1 
ATOM   2629 C  CZ2 . TRP A 1 324 ? -17.01016 34.24522 -5.78622  1.000 13.11063 ? 324  TRP A CZ2 1 
ATOM   2630 C  CZ3 . TRP A 1 324 ? -18.11814 35.70251 -4.20919  1.000 15.98963 ? 324  TRP A CZ3 1 
ATOM   2631 C  CH2 . TRP A 1 324 ? -17.16759 34.71560 -4.51252  1.000 11.45081 ? 324  TRP A CH2 1 
ATOM   2632 N  N   . LEU A 1 325 ? -17.67574 38.42151 -9.26395  1.000 8.63019  ? 325  LEU A N   1 
ATOM   2633 C  CA  . LEU A 1 325 ? -16.30990 38.80906 -8.94178  1.000 9.27894  ? 325  LEU A CA  1 
ATOM   2634 C  C   . LEU A 1 325 ? -16.13105 40.32518 -8.92697  1.000 11.05712 ? 325  LEU A C   1 
ATOM   2635 O  O   . LEU A 1 325 ? -15.18879 40.82896 -8.29948  1.000 14.20532 ? 325  LEU A O   1 
ATOM   2636 C  CB  . LEU A 1 325 ? -15.34544 38.15701 -9.92883  1.000 9.28291  ? 325  LEU A CB  1 
ATOM   2637 C  CG  . LEU A 1 325 ? -15.20728 36.63461 -9.82573  1.000 10.32694 ? 325  LEU A CG  1 
ATOM   2638 C  CD1 . LEU A 1 325 ? -14.10905 36.15376 -10.78019 1.000 8.53827  ? 325  LEU A CD1 1 
ATOM   2639 C  CD2 . LEU A 1 325 ? -14.90881 36.21889 -8.37767  1.000 7.44027  ? 325  LEU A CD2 1 
ATOM   2640 N  N   . ASP A 1 326 ? -17.01351 41.05999 -9.59894  1.000 8.26195  ? 326  ASP A N   1 
ATOM   2641 C  CA  . ASP A 1 326 ? -16.91602 42.51187 -9.58229  1.000 12.46073 ? 326  ASP A CA  1 
ATOM   2642 C  C   . ASP A 1 326 ? -17.10859 43.06713 -8.17535  1.000 11.97706 ? 326  ASP A C   1 
ATOM   2643 O  O   . ASP A 1 326 ? -16.55712 44.12338 -7.84309  1.000 11.73350 ? 326  ASP A O   1 
ATOM   2644 C  CB  . ASP A 1 326 ? -17.94243 43.09446 -10.55326 1.000 11.53514 ? 326  ASP A CB  1 
ATOM   2645 C  CG  . ASP A 1 326 ? -17.53599 42.89665 -12.00570 1.000 13.35155 ? 326  ASP A CG  1 
ATOM   2646 O  OD1 . ASP A 1 326 ? -16.35654 42.54681 -12.24193 1.000 13.27998 ? 326  ASP A OD1 1 
ATOM   2647 O  OD2 . ASP A 1 326 ? -18.38235 43.08686 -12.90381 1.000 11.85267 ? 326  ASP A OD2 1 
ATOM   2648 N  N   . SER A 1 327 ? -17.87754 42.36805 -7.33407  1.000 9.48778  ? 327  SER A N   1 
ATOM   2649 C  CA  . SER A 1 327 ? -18.06723 42.80950 -5.95729  1.000 13.37446 ? 327  SER A CA  1 
ATOM   2650 C  C   . SER A 1 327 ? -16.77233 42.73839 -5.15923  1.000 12.34703 ? 327  SER A C   1 
ATOM   2651 O  O   . SER A 1 327 ? -16.65517 43.41544 -4.13152  1.000 11.23557 ? 327  SER A O   1 
ATOM   2652 C  CB  . SER A 1 327 ? -19.15320 41.97220 -5.27058  1.000 13.08278 ? 327  SER A CB  1 
ATOM   2653 O  OG  . SER A 1 327 ? -18.64544 40.67594 -4.94705  1.000 14.52525 ? 327  SER A OG  1 
ATOM   2654 N  N   . ARG A 1 328 ? -15.80286 41.94396 -5.61643  1.000 11.02825 ? 328  ARG A N   1 
ATOM   2655 C  CA  . ARG A 1 328 ? -14.48302 41.86162 -5.00392  1.000 14.37392 ? 328  ARG A CA  1 
ATOM   2656 C  C   . ARG A 1 328 ? -13.44028 42.69597 -5.73543  1.000 15.43856 ? 328  ARG A C   1 
ATOM   2657 O  O   . ARG A 1 328 ? -12.28649 42.73997 -5.29938  1.000 14.05667 ? 328  ARG A O   1 
ATOM   2658 C  CB  . ARG A 1 328 ? -14.00345 40.40558 -4.95973  1.000 13.45995 ? 328  ARG A CB  1 
ATOM   2659 C  CG  . ARG A 1 328 ? -14.77677 39.52362 -4.01967  1.000 15.92295 ? 328  ARG A CG  1 
ATOM   2660 C  CD  . ARG A 1 328 ? -15.26626 38.28030 -4.72484  1.000 15.27731 ? 328  ARG A CD  1 
ATOM   2661 N  NE  . ARG A 1 328 ? -14.22771 37.27539 -4.97741  1.000 12.05260 ? 328  ARG A NE  1 
ATOM   2662 C  CZ  . ARG A 1 328 ? -13.92498 36.26848 -4.15457  1.000 15.67238 ? 328  ARG A CZ  1 
ATOM   2663 N  NH1 . ARG A 1 328 ? -14.54766 36.13584 -2.99296  1.000 14.77257 ? 328  ARG A NH1 1 
ATOM   2664 N  NH2 . ARG A 1 328 ? -12.99779 35.39038 -4.50051  1.000 13.30270 ? 328  ARG A NH2 1 
ATOM   2665 N  N   . ALA A 1 329 ? -13.80801 43.34198 -6.84280  1.000 10.44465 ? 329  ALA A N   1 
ATOM   2666 C  CA  . ALA A 1 329 ? -12.83107 44.01669 -7.70019  1.000 11.66028 ? 329  ALA A CA  1 
ATOM   2667 C  C   . ALA A 1 329 ? -12.54662 45.40456 -7.12845  1.000 14.06047 ? 329  ALA A C   1 
ATOM   2668 O  O   . ALA A 1 329 ? -13.04448 46.42699 -7.60614  1.000 11.56190 ? 329  ALA A O   1 
ATOM   2669 C  CB  . ALA A 1 329 ? -13.34639 44.08306 -9.13540  1.000 13.60823 ? 329  ALA A CB  1 
ATOM   2670 N  N   . ASP A 1 330 ? -11.73156 45.42921 -6.07131  1.000 13.72154 ? 330  ASP A N   1 
ATOM   2671 C  CA  . ASP A 1 330 ? -11.36096 46.67719 -5.40919  1.000 13.02050 ? 330  ASP A CA  1 
ATOM   2672 C  C   . ASP A 1 330 ? -10.33184 47.43208 -6.24657  1.000 12.40294 ? 330  ASP A C   1 
ATOM   2673 O  O   . ASP A 1 330 ? -9.34812  46.84188 -6.69843  1.000 12.14775 ? 330  ASP A O   1 
ATOM   2674 C  CB  . ASP A 1 330 ? -10.77186 46.40308 -4.02579  1.000 11.94324 ? 330  ASP A CB  1 
ATOM   2675 C  CG  . ASP A 1 330 ? -11.68226 45.57448 -3.12721  1.000 14.91783 ? 330  ASP A CG  1 
ATOM   2676 O  OD1 . ASP A 1 330 ? -12.92051 45.55826 -3.32404  1.000 14.06452 ? 330  ASP A OD1 1 
ATOM   2677 O  OD2 . ASP A 1 330 ? -11.13353 44.95494 -2.18669  1.000 16.48157 ? 330  ASP A OD2 1 
ATOM   2678 N  N   . VAL A 1 331 ? -10.53274 48.73951 -6.42871  1.000 11.08501 ? 331  VAL A N   1 
ATOM   2679 C  CA  . VAL A 1 331 ? -9.60363  49.56091 -7.20324  1.000 11.11898 ? 331  VAL A CA  1 
ATOM   2680 C  C   . VAL A 1 331 ? -8.77526  50.41111 -6.24800  1.000 12.95361 ? 331  VAL A C   1 
ATOM   2681 O  O   . VAL A 1 331 ? -9.32336  51.20702 -5.47620  1.000 12.86528 ? 331  VAL A O   1 
ATOM   2682 C  CB  . VAL A 1 331 ? -10.32977 50.45455 -8.21929  1.000 13.25052 ? 331  VAL A CB  1 
ATOM   2683 C  CG1 . VAL A 1 331 ? -9.29752  51.15520 -9.10123  1.000 11.02782 ? 331  VAL A CG1 1 
ATOM   2684 C  CG2 . VAL A 1 331 ? -11.30183 49.63854 -9.07123  1.000 12.17606 ? 331  VAL A CG2 1 
ATOM   2685 N  N   . TYR A 1 332 ? -7.45937  50.25713 -6.32762  1.000 10.85137 ? 332  TYR A N   1 
ATOM   2686 C  CA  . TYR A 1 332 ? -6.50598  50.96678 -5.48880  1.000 11.33965 ? 332  TYR A CA  1 
ATOM   2687 C  C   . TYR A 1 332 ? -5.94199  52.15609 -6.25328  1.000 14.25330 ? 332  TYR A C   1 
ATOM   2688 O  O   . TYR A 1 332 ? -5.55342  52.02248 -7.42061  1.000 14.28063 ? 332  TYR A O   1 
ATOM   2689 C  CB  . TYR A 1 332 ? -5.35989  50.04306 -5.07493  1.000 14.42316 ? 332  TYR A CB  1 
ATOM   2690 C  CG  . TYR A 1 332 ? -5.75317  48.92067 -4.13341  1.000 16.01757 ? 332  TYR A CG  1 
ATOM   2691 C  CD1 . TYR A 1 332 ? -6.62294  47.91776 -4.53533  1.000 11.35850 ? 332  TYR A CD1 1 
ATOM   2692 C  CD2 . TYR A 1 332 ? -5.24086  48.86984 -2.84291  1.000 17.74351 ? 332  TYR A CD2 1 
ATOM   2693 C  CE1 . TYR A 1 332 ? -6.97886  46.89516 -3.67838  1.000 11.62094 ? 332  TYR A CE1 1 
ATOM   2694 C  CE2 . TYR A 1 332 ? -5.58412  47.85024 -1.97664  1.000 19.93115 ? 332  TYR A CE2 1 
ATOM   2695 C  CZ  . TYR A 1 332 ? -6.45324  46.86561 -2.39918  1.000 17.34269 ? 332  TYR A CZ  1 
ATOM   2696 O  OH  . TYR A 1 332 ? -6.79296  45.84909 -1.53637  1.000 13.22125 ? 332  TYR A OH  1 
ATOM   2697 N  N   . TYR A 1 333 ? -5.87808  53.30905 -5.58565  1.000 13.95471 ? 333  TYR A N   1 
ATOM   2698 C  CA  . TYR A 1 333 ? -5.41731  54.56231 -6.18217  1.000 15.59790 ? 333  TYR A CA  1 
ATOM   2699 C  C   . TYR A 1 333 ? -4.23909  55.12663 -5.39438  1.000 15.28152 ? 333  TYR A C   1 
ATOM   2700 O  O   . TYR A 1 333 ? -4.29943  55.20360 -4.16426  1.000 14.93567 ? 333  TYR A O   1 
ATOM   2701 C  CB  . TYR A 1 333 ? -6.55346  55.59165 -6.20492  1.000 17.95845 ? 333  TYR A CB  1 
ATOM   2702 C  CG  . TYR A 1 333 ? -7.66927  55.24344 -7.16181  1.000 14.88853 ? 333  TYR A CG  1 
ATOM   2703 C  CD1 . TYR A 1 333 ? -7.58249  55.58650 -8.49901  1.000 18.57400 ? 333  TYR A CD1 1 
ATOM   2704 C  CD2 . TYR A 1 333 ? -8.80218  54.56712 -6.72954  1.000 16.34184 ? 333  TYR A CD2 1 
ATOM   2705 C  CE1 . TYR A 1 333 ? -8.59505  55.26964 -9.39345  1.000 19.79174 ? 333  TYR A CE1 1 
ATOM   2706 C  CE2 . TYR A 1 333 ? -9.82433  54.24603 -7.61735  1.000 16.46181 ? 333  TYR A CE2 1 
ATOM   2707 C  CZ  . TYR A 1 333 ? -9.71236  54.60627 -8.94817  1.000 16.64224 ? 333  TYR A CZ  1 
ATOM   2708 O  OH  . TYR A 1 333 ? -10.70864 54.28767 -9.85322  1.000 17.99021 ? 333  TYR A OH  1 
ATOM   2709 N  N   . ASP A 1 334 ? -3.18591  55.54612 -6.09735  1.000 15.17878 ? 334  ASP A N   1 
ATOM   2710 C  CA  . ASP A 1 334 ? -2.07178  56.20847 -5.43016  1.000 18.97073 ? 334  ASP A CA  1 
ATOM   2711 C  C   . ASP A 1 334 ? -2.42000  57.67165 -5.14842  1.000 23.32696 ? 334  ASP A C   1 
ATOM   2712 O  O   . ASP A 1 334 ? -3.53054  58.14142 -5.42213  1.000 21.80648 ? 334  ASP A O   1 
ATOM   2713 C  CB  . ASP A 1 334 ? -0.78106  56.06061 -6.24106  1.000 18.33990 ? 334  ASP A CB  1 
ATOM   2714 C  CG  . ASP A 1 334 ? -0.77990  56.85498 -7.55984  1.000 21.74670 ? 334  ASP A CG  1 
ATOM   2715 O  OD1 . ASP A 1 334 ? -1.56159  57.80468 -7.73789  1.000 21.96321 ? 334  ASP A OD1 1 
ATOM   2716 O  OD2 . ASP A 1 334 ? 0.03370   56.51286 -8.43933  1.000 23.74063 ? 334  ASP A OD2 1 
ATOM   2717 N  N   . ALA A 1 335 ? -1.45067  58.40623 -4.59540  1.000 24.02291 ? 335  ALA A N   1 
ATOM   2718 C  CA  . ALA A 1 335 ? -1.72247  59.76407 -4.12538  1.000 24.25392 ? 335  ALA A CA  1 
ATOM   2719 C  C   . ALA A 1 335 ? -2.03947  60.71824 -5.27672  1.000 27.42486 ? 335  ALA A C   1 
ATOM   2720 O  O   . ALA A 1 335 ? -2.71612  61.73134 -5.07248  1.000 31.03236 ? 335  ALA A O   1 
ATOM   2721 C  CB  . ALA A 1 335 ? -0.53467  60.28074 -3.30947  1.000 26.13968 ? 335  ALA A CB  1 
ATOM   2722 N  N   . ASN A 1 336 ? -1.56880  60.41803 -6.48219  1.000 22.65339 ? 336  ASN A N   1 
ATOM   2723 C  CA  . ASN A 1 336 ? -1.89539  61.20278 -7.66440  1.000 26.80118 ? 336  ASN A CA  1 
ATOM   2724 C  C   . ASN A 1 336 ? -3.19736  60.77076 -8.32856  1.000 32.52525 ? 336  ASN A C   1 
ATOM   2725 O  O   . ASN A 1 336 ? -3.54707  61.31772 -9.38027  1.000 32.01549 ? 336  ASN A O   1 
ATOM   2726 C  CB  . ASN A 1 336 ? -0.75702  61.11282 -8.68561  1.000 25.48245 ? 336  ASN A CB  1 
ATOM   2727 C  CG  . ASN A 1 336 ? 0.52110   61.72430 -8.17363  1.000 34.71421 ? 336  ASN A CG  1 
ATOM   2728 O  OD1 . ASN A 1 336 ? 0.49133   62.70178 -7.43112  1.000 34.73964 ? 336  ASN A OD1 1 
ATOM   2729 N  ND2 . ASN A 1 336 ? 1.65315   61.14964 -8.55842  1.000 34.47621 ? 336  ASN A ND2 1 
ATOM   2730 N  N   . GLY A 1 337 ? -3.91403  59.80274 -7.75702  1.000 23.69144 ? 337  GLY A N   1 
ATOM   2731 C  CA  . GLY A 1 337 ? -5.13126  59.31930 -8.36791  1.000 22.72519 ? 337  GLY A CA  1 
ATOM   2732 C  C   . GLY A 1 337 ? -4.94823  58.34634 -9.51308  1.000 22.20594 ? 337  GLY A C   1 
ATOM   2733 O  O   . GLY A 1 337 ? -5.90827  58.11163 -10.25708 1.000 25.82288 ? 337  GLY A O   1 
ATOM   2734 N  N   . ASN A 1 338 ? -3.75872  57.77721 -9.68946  1.000 20.76724 ? 338  ASN A N   1 
ATOM   2735 C  CA  . ASN A 1 338 ? -3.54951  56.74413 -10.69435 1.000 19.51624 ? 338  ASN A CA  1 
ATOM   2736 C  C   . ASN A 1 338 ? -3.83854  55.36316 -10.10906 1.000 20.21889 ? 338  ASN A C   1 
ATOM   2737 O  O   . ASN A 1 338 ? -3.62805  55.11636 -8.91645  1.000 16.98179 ? 338  ASN A O   1 
ATOM   2738 C  CB  . ASN A 1 338 ? -2.11999  56.80202 -11.23440 1.000 21.74014 ? 338  ASN A CB  1 
ATOM   2739 C  CG  . ASN A 1 338 ? -1.79685  58.15143 -11.87024 1.000 28.98268 ? 338  ASN A CG  1 
ATOM   2740 O  OD1 . ASN A 1 338 ? -2.59174  58.69063 -12.63375 1.000 34.50245 ? 338  ASN A OD1 1 
ATOM   2741 N  ND2 . ASN A 1 338 ? -0.64723  58.70832 -11.53107 1.000 30.56058 ? 338  ASN A ND2 1 
ATOM   2742 N  N   . VAL A 1 339 ? -4.32426  54.46226 -10.96930 1.000 14.01970 ? 339  VAL A N   1 
ATOM   2743 C  CA  . VAL A 1 339 ? -4.70753  53.12057 -10.54100 1.000 14.70321 ? 339  VAL A CA  1 
ATOM   2744 C  C   . VAL A 1 339 ? -3.46406  52.32126 -10.17880 1.000 14.14407 ? 339  VAL A C   1 
ATOM   2745 O  O   . VAL A 1 339 ? -2.43371  52.41054 -10.85245 1.000 16.77977 ? 339  VAL A O   1 
ATOM   2746 C  CB  . VAL A 1 339 ? -5.50683  52.41681 -11.65099 1.000 15.36103 ? 339  VAL A CB  1 
ATOM   2747 C  CG1 . VAL A 1 339 ? -5.65147  50.92707 -11.34784 1.000 13.13663 ? 339  VAL A CG1 1 
ATOM   2748 C  CG2 . VAL A 1 339 ? -6.86152  53.08447 -11.83143 1.000 14.40913 ? 339  VAL A CG2 1 
ATOM   2749 N  N   . VAL A 1 340 ? -3.54964  51.53894 -9.10553  1.000 13.94796 ? 340  VAL A N   1 
ATOM   2750 C  CA  . VAL A 1 340 ? -2.44618  50.69391 -8.66045  1.000 15.30778 ? 340  VAL A CA  1 
ATOM   2751 C  C   . VAL A 1 340 ? -2.90793  49.24482 -8.72700  1.000 15.41190 ? 340  VAL A C   1 
ATOM   2752 O  O   . VAL A 1 340 ? -3.86634  48.86171 -8.04325  1.000 13.25340 ? 340  VAL A O   1 
ATOM   2753 C  CB  . VAL A 1 340 ? -1.97834  51.05589 -7.24031  1.000 17.00289 ? 340  VAL A CB  1 
ATOM   2754 C  CG1 . VAL A 1 340 ? -0.80917  50.15397 -6.81533  1.000 16.18367 ? 340  VAL A CG1 1 
ATOM   2755 C  CG2 . VAL A 1 340 ? -1.58462  52.52662 -7.17239  1.000 16.34691 ? 340  VAL A CG2 1 
ATOM   2756 N  N   . VAL A 1 341 ? -2.23430  48.44659 -9.55028  1.000 12.47325 ? 341  VAL A N   1 
ATOM   2757 C  CA  . VAL A 1 341 ? -2.55635  47.03240 -9.67905  1.000 17.01086 ? 341  VAL A CA  1 
ATOM   2758 C  C   . VAL A 1 341 ? -1.45520  46.13081 -9.13334  1.000 18.88611 ? 341  VAL A C   1 
ATOM   2759 O  O   . VAL A 1 341 ? -1.73470  44.95943 -8.83280  1.000 15.38727 ? 341  VAL A O   1 
ATOM   2760 C  CB  . VAL A 1 341 ? -2.88596  46.65858 -11.13913 1.000 14.61470 ? 341  VAL A CB  1 
ATOM   2761 C  CG1 . VAL A 1 341 ? -4.19112  47.30995 -11.54896 1.000 14.36471 ? 341  VAL A CG1 1 
ATOM   2762 C  CG2 . VAL A 1 341 ? -1.76580  47.08666 -12.07806 1.000 17.51499 ? 341  VAL A CG2 1 
ATOM   2763 N  N   . ASP A 1 342 ? -0.23112  46.63084 -8.98468  1.000 16.32193 ? 342  ASP A N   1 
ATOM   2764 C  CA  . ASP A 1 342 ? 0.84701   45.87935 -8.34846  1.000 19.76351 ? 342  ASP A CA  1 
ATOM   2765 C  C   . ASP A 1 342 ? 0.48889   45.56969 -6.89522  1.000 16.21073 ? 342  ASP A C   1 
ATOM   2766 O  O   . ASP A 1 342 ? 0.25448   46.50071 -6.10926  1.000 16.67427 ? 342  ASP A O   1 
ATOM   2767 C  CB  . ASP A 1 342 ? 2.13875   46.69797 -8.44035  1.000 22.89892 ? 342  ASP A CB  1 
ATOM   2768 C  CG  . ASP A 1 342 ? 3.35202   46.00409 -7.82069  1.000 28.65935 ? 342  ASP A CG  1 
ATOM   2769 O  OD1 . ASP A 1 342 ? 3.20887   45.04666 -7.02302  1.000 31.15288 ? 342  ASP A OD1 1 
ATOM   2770 O  OD2 . ASP A 1 342 ? 4.47948   46.45907 -8.11998  1.000 31.17673 ? 342  ASP A OD2 1 
ATOM   2771 N  N   . PRO A 1 343 ? 0.47796   44.29892 -6.48505  1.000 24.79639 ? 343  PRO A N   1 
ATOM   2772 C  CA  . PRO A 1 343 ? 0.02735   43.96546 -5.11753  1.000 24.71559 ? 343  PRO A CA  1 
ATOM   2773 C  C   . PRO A 1 343 ? 0.89937   44.52051 -3.99311  1.000 28.32383 ? 343  PRO A C   1 
ATOM   2774 O  O   . PRO A 1 343 ? 0.41757   44.63706 -2.85813  1.000 28.81216 ? 343  PRO A O   1 
ATOM   2775 C  CB  . PRO A 1 343 ? 0.02487   42.42741 -5.11295  1.000 27.17141 ? 343  PRO A CB  1 
ATOM   2776 C  CG  . PRO A 1 343 ? 0.85788   42.02775 -6.28596  1.000 25.94439 ? 343  PRO A CG  1 
ATOM   2777 C  CD  . PRO A 1 343 ? 0.68888   43.09749 -7.30937  1.000 21.36777 ? 343  PRO A CD  1 
ATOM   2778 N  N   . ASN A 1 344 ? 2.15002   44.87906 -4.25258  1.000 23.95519 ? 344  ASN A N   1 
ATOM   2779 C  CA  . ASN A 1 344 ? 3.00596   45.36418 -3.17796  1.000 34.33312 ? 344  ASN A CA  1 
ATOM   2780 C  C   . ASN A 1 344 ? 3.19294   46.87717 -3.18591  1.000 32.18596 ? 344  ASN A C   1 
ATOM   2781 O  O   . ASN A 1 344 ? 3.79517   47.41385 -2.24812  1.000 31.33781 ? 344  ASN A O   1 
ATOM   2782 C  CB  . ASN A 1 344 ? 4.37639   44.67667 -3.25391  1.000 37.96658 ? 344  ASN A CB  1 
ATOM   2783 C  CG  . ASN A 1 344 ? 4.27334   43.17053 -3.10295  1.000 41.75541 ? 344  ASN A CG  1 
ATOM   2784 O  OD1 . ASN A 1 344 ? 4.70874   42.41039 -3.97206  1.000 39.61923 ? 344  ASN A OD1 1 
ATOM   2785 N  ND2 . ASN A 1 344 ? 3.67707   42.73151 -2.00082  1.000 32.93427 ? 344  ASN A ND2 1 
ATOM   2786 N  N   . ALA A 1 345 ? 2.66548   47.57061 -4.19066  1.000 26.21244 ? 345  ALA A N   1 
ATOM   2787 C  CA  . ALA A 1 345 ? 2.98598   48.96404 -4.44710  1.000 19.68293 ? 345  ALA A CA  1 
ATOM   2788 C  C   . ALA A 1 345 ? 2.28120   49.91060 -3.47666  1.000 16.18376 ? 345  ALA A C   1 
ATOM   2789 O  O   . ALA A 1 345 ? 1.22719   49.58643 -2.92181  1.000 13.97215 ? 345  ALA A O   1 
ATOM   2790 C  CB  . ALA A 1 345 ? 2.60716   49.32269 -5.88138  1.000 20.43591 ? 345  ALA A CB  1 
ATOM   2791 N  N   . PRO A 1 346 ? 2.84383   51.10745 -3.27641  1.000 15.60165 ? 346  PRO A N   1 
ATOM   2792 C  CA  . PRO A 1 346 ? 2.16330   52.12486 -2.46665  1.000 17.12669 ? 346  PRO A CA  1 
ATOM   2793 C  C   . PRO A 1 346 ? 0.79555   52.49059 -3.02965  1.000 18.09323 ? 346  PRO A C   1 
ATOM   2794 O  O   . PRO A 1 346 ? 0.54558   52.41367 -4.23596  1.000 17.16655 ? 346  PRO A O   1 
ATOM   2795 C  CB  . PRO A 1 346 ? 3.11023   53.33212 -2.53517  1.000 18.59615 ? 346  PRO A CB  1 
ATOM   2796 C  CG  . PRO A 1 346 ? 4.38531   52.83012 -3.08169  1.000 21.93957 ? 346  PRO A CG  1 
ATOM   2797 C  CD  . PRO A 1 346 ? 4.08828   51.61440 -3.88230  1.000 19.55480 ? 346  PRO A CD  1 
ATOM   2798 N  N   . TYR A 1 347 ? -0.08317  52.92633 -2.13526  1.000 14.35150 ? 347  TYR A N   1 
ATOM   2799 C  CA  . TYR A 1 347 ? -1.39207  53.41014 -2.52905  1.000 17.83396 ? 347  TYR A CA  1 
ATOM   2800 C  C   . TYR A 1 347 ? -1.95930  54.20953 -1.36665  1.000 20.15074 ? 347  TYR A C   1 
ATOM   2801 O  O   . TYR A 1 347 ? -1.53158  54.05463 -0.21676  1.000 16.78167 ? 347  TYR A O   1 
ATOM   2802 C  CB  . TYR A 1 347 ? -2.31494  52.25622 -2.94647  1.000 15.46001 ? 347  TYR A CB  1 
ATOM   2803 C  CG  . TYR A 1 347 ? -3.01440  51.53291 -1.81659  1.000 18.10188 ? 347  TYR A CG  1 
ATOM   2804 C  CD1 . TYR A 1 347 ? -4.26280  51.94953 -1.36560  1.000 15.77990 ? 347  TYR A CD1 1 
ATOM   2805 C  CD2 . TYR A 1 347 ? -2.44298  50.41338 -1.22232  1.000 17.94530 ? 347  TYR A CD2 1 
ATOM   2806 C  CE1 . TYR A 1 347 ? -4.92193  51.27387 -0.33679  1.000 19.84754 ? 347  TYR A CE1 1 
ATOM   2807 C  CE2 . TYR A 1 347 ? -3.09505  49.73602 -0.19107  1.000 16.31368 ? 347  TYR A CE2 1 
ATOM   2808 C  CZ  . TYR A 1 347 ? -4.33046  50.17260 0.23977   1.000 19.32936 ? 347  TYR A CZ  1 
ATOM   2809 O  OH  . TYR A 1 347 ? -4.97536  49.51001 1.25509   1.000 24.68820 ? 347  TYR A OH  1 
ATOM   2810 N  N   . ALA A 1 348 ? -2.90897  55.08749 -1.68972  1.000 12.30358 ? 348  ALA A N   1 
ATOM   2811 C  CA  . ALA A 1 348 ? -3.52487  55.98545 -0.72082  1.000 16.74807 ? 348  ALA A CA  1 
ATOM   2812 C  C   . ALA A 1 348 ? -4.94321  55.59811 -0.34849  1.000 22.82289 ? 348  ALA A C   1 
ATOM   2813 O  O   . ALA A 1 348 ? -5.30921  55.68329 0.82779   1.000 18.61474 ? 348  ALA A O   1 
ATOM   2814 C  CB  . ALA A 1 348 ? -3.52714  57.42497 -1.25880  1.000 19.57628 ? 348  ALA A CB  1 
ATOM   2815 N  N   . LYS A 1 349 ? -5.76405  55.18177 -1.31321  1.000 19.08150 ? 349  LYS A N   1 
ATOM   2816 C  CA  . LYS A 1 349 ? -7.15036  54.84280 -1.02241  1.000 18.48068 ? 349  LYS A CA  1 
ATOM   2817 C  C   . LYS A 1 349 ? -7.57722  53.67050 -1.89103  1.000 16.42301 ? 349  LYS A C   1 
ATOM   2818 O  O   . LYS A 1 349 ? -6.93594  53.34648 -2.89473  1.000 18.29500 ? 349  LYS A O   1 
ATOM   2819 C  CB  . LYS A 1 349 ? -8.09212  56.04193 -1.24039  1.000 24.03126 ? 349  LYS A CB  1 
ATOM   2820 C  CG  . LYS A 1 349 ? -8.22640  56.49316 -2.69879  1.000 26.26728 ? 349  LYS A CG  1 
ATOM   2821 C  CD  . LYS A 1 349 ? -9.10543  57.75422 -2.82521  1.000 35.31124 ? 349  LYS A CD  1 
ATOM   2822 C  CE  . LYS A 1 349 ? -9.75663  57.89717 -4.22195  1.000 34.49838 ? 349  LYS A CE  1 
ATOM   2823 N  NZ  . LYS A 1 349 ? -8.98887  58.71566 -5.22949  1.000 33.73816 ? 349  LYS A NZ  1 
ATOM   2824 N  N   . VAL A 1 350 ? -8.67357  53.03159 -1.48894  1.000 16.98654 ? 350  VAL A N   1 
ATOM   2825 C  CA  . VAL A 1 350 ? -9.25150  51.92209 -2.23549  1.000 19.42511 ? 350  VAL A CA  1 
ATOM   2826 C  C   . VAL A 1 350 ? -10.74812 52.16325 -2.41537  1.000 18.64928 ? 350  VAL A C   1 
ATOM   2827 O  O   . VAL A 1 350 ? -11.43370 52.63292 -1.49957  1.000 17.76698 ? 350  VAL A O   1 
ATOM   2828 C  CB  . VAL A 1 350 ? -8.97660  50.57088 -1.53853  1.000 18.92356 ? 350  VAL A CB  1 
ATOM   2829 C  CG1 . VAL A 1 350 ? -9.45543  50.59946 -0.09767  1.000 24.92938 ? 350  VAL A CG1 1 
ATOM   2830 C  CG2 . VAL A 1 350 ? -9.63479  49.42693 -2.30781  1.000 19.12721 ? 350  VAL A CG2 1 
ATOM   2831 N  N   . GLU A 1 351 ? -11.25197 51.86007 -3.60786  1.000 16.94294 ? 351  GLU A N   1 
ATOM   2832 C  CA  . GLU A 1 351 ? -12.68609 51.90390 -3.88759  1.000 16.82321 ? 351  GLU A CA  1 
ATOM   2833 C  C   . GLU A 1 351 ? -13.17323 50.46343 -4.01687  1.000 15.75250 ? 351  GLU A C   1 
ATOM   2834 O  O   . GLU A 1 351 ? -13.01776 49.83490 -5.06824  1.000 13.62323 ? 351  GLU A O   1 
ATOM   2835 C  CB  . GLU A 1 351 ? -12.96057 52.72912 -5.13686  1.000 15.10480 ? 351  GLU A CB  1 
ATOM   2836 C  CG  . GLU A 1 351 ? -12.70583 54.21609 -4.90514  1.000 22.04945 ? 351  GLU A CG  1 
ATOM   2837 C  CD  . GLU A 1 351 ? -12.98542 55.06393 -6.13065  1.000 32.35515 ? 351  GLU A CD  1 
ATOM   2838 O  OE1 . GLU A 1 351 ? -13.48580 54.51128 -7.13665  1.000 35.08302 ? 351  GLU A OE1 1 
ATOM   2839 O  OE2 . GLU A 1 351 ? -12.69962 56.28119 -6.09177  1.000 37.17683 ? 351  GLU A OE2 1 
ATOM   2840 N  N   . LYS A 1 352 ? -13.76157 49.94514 -2.94450  1.000 12.63864 ? 352  LYS A N   1 
ATOM   2841 C  CA  . LYS A 1 352 ? -14.04635 48.51844 -2.86851  1.000 16.07158 ? 352  LYS A CA  1 
ATOM   2842 C  C   . LYS A 1 352 ? -15.19691 48.14286 -3.79224  1.000 14.31972 ? 352  LYS A C   1 
ATOM   2843 O  O   . LYS A 1 352 ? -16.22113 48.82518 -3.83208  1.000 16.85125 ? 352  LYS A O   1 
ATOM   2844 C  CB  . LYS A 1 352 ? -14.36711 48.12358 -1.42947  1.000 19.32488 ? 352  LYS A CB  1 
ATOM   2845 C  CG  . LYS A 1 352 ? -13.13204 48.08277 -0.51415  1.000 24.34269 ? 352  LYS A CG  1 
ATOM   2846 C  CD  . LYS A 1 352 ? -13.45951 47.42554 0.82852   1.000 35.39322 ? 352  LYS A CD  1 
ATOM   2847 C  CE  . LYS A 1 352 ? -12.24807 46.74213 1.44839   1.000 34.08106 ? 352  LYS A CE  1 
ATOM   2848 N  NZ  . LYS A 1 352 ? -12.56822 46.18565 2.80815   1.000 40.92664 ? 352  LYS A NZ  1 
ATOM   2849 N  N   . GLY A 1 353 ? -15.02349 47.05397 -4.53888  1.000 13.54016 ? 353  GLY A N   1 
ATOM   2850 C  CA  . GLY A 1 353 ? -16.09308 46.56423 -5.39485  1.000 13.28252 ? 353  GLY A CA  1 
ATOM   2851 C  C   . GLY A 1 353 ? -16.45170 47.45367 -6.56508  1.000 15.15110 ? 353  GLY A C   1 
ATOM   2852 O  O   . GLY A 1 353 ? -17.53268 47.29495 -7.13947  1.000 16.99037 ? 353  GLY A O   1 
ATOM   2853 N  N   . LYS A 1 354 ? -15.57068 48.38134 -6.94966  1.000 11.45164 ? 354  LYS A N   1 
ATOM   2854 C  CA  . LYS A 1 354 ? -15.86544 49.34247 -8.00452  1.000 15.92978 ? 354  LYS A CA  1 
ATOM   2855 C  C   . LYS A 1 354 ? -15.20541 49.01554 -9.34488  1.000 15.76923 ? 354  LYS A C   1 
ATOM   2856 O  O   . LYS A 1 354 ? -15.47871 49.70661 -10.32806 1.000 14.53093 ? 354  LYS A O   1 
ATOM   2857 C  CB  . LYS A 1 354 ? -15.43901 50.75427 -7.56381  1.000 14.54954 ? 354  LYS A CB  1 
ATOM   2858 C  CG  . LYS A 1 354 ? -16.34212 51.37992 -6.49809  1.000 22.18014 ? 354  LYS A CG  1 
ATOM   2859 C  CD  . LYS A 1 354 ? -17.80936 51.24837 -6.87880  1.000 26.52968 ? 354  LYS A CD  1 
ATOM   2860 C  CE  . LYS A 1 354 ? -18.67259 52.27717 -6.17447  1.000 40.18654 ? 354  LYS A CE  1 
ATOM   2861 N  NZ  . LYS A 1 354 ? -18.67344 52.04657 -4.70695  1.000 49.21068 ? 354  LYS A NZ  1 
ATOM   2862 N  N   . GLY A 1 355 ? -14.35504 47.99411 -9.41773  1.000 11.57214 ? 355  GLY A N   1 
ATOM   2863 C  CA  . GLY A 1 355 ? -13.63144 47.66000 -10.63063 1.000 10.01250 ? 355  GLY A CA  1 
ATOM   2864 C  C   . GLY A 1 355 ? -14.28882 46.55774 -11.44088 1.000 13.00626 ? 355  GLY A C   1 
ATOM   2865 O  O   . GLY A 1 355 ? -15.45883 46.21470 -11.24643 1.000 11.66946 ? 355  GLY A O   1 
ATOM   2866 N  N   . LYS A 1 356 ? -13.51471 45.98511 -12.36423 1.000 9.73006  ? 356  LYS A N   1 
ATOM   2867 C  CA  . LYS A 1 356 ? -14.05326 45.02851 -13.32214 1.000 12.06288 ? 356  LYS A CA  1 
ATOM   2868 C  C   . LYS A 1 356 ? -13.12043 43.83300 -13.41751 1.000 9.17951  ? 356  LYS A C   1 
ATOM   2869 O  O   . LYS A 1 356 ? -11.92646 43.99546 -13.68903 1.000 10.76817 ? 356  LYS A O   1 
ATOM   2870 C  CB  . LYS A 1 356 ? -14.24330 45.67579 -14.70385 1.000 10.78536 ? 356  LYS A CB  1 
ATOM   2871 C  CG  . LYS A 1 356 ? -15.11984 44.85331 -15.66671 1.000 12.46325 ? 356  LYS A CG  1 
ATOM   2872 C  CD  . LYS A 1 356 ? -16.60939 44.93637 -15.28526 1.000 10.48959 ? 356  LYS A CD  1 
ATOM   2873 C  CE  . LYS A 1 356 ? -17.41692 43.80002 -15.93861 1.000 10.59906 ? 356  LYS A CE  1 
ATOM   2874 N  NZ  . LYS A 1 356 ? -17.14754 42.48502 -15.27129 1.000 8.87979  ? 356  LYS A NZ  1 
ATOM   2875 N  N   . ASP A 1 357 ? -13.67325 42.64195 -13.20373 1.000 10.68999 ? 357  ASP A N   1 
ATOM   2876 C  CA  . ASP A 1 357 ? -13.01830 41.37754 -13.50456 1.000 11.22939 ? 357  ASP A CA  1 
ATOM   2877 C  C   . ASP A 1 357 ? -13.53302 40.84570 -14.84258 1.000 10.18154 ? 357  ASP A C   1 
ATOM   2878 O  O   . ASP A 1 357 ? -14.50263 41.35295 -15.41711 1.000 9.90297  ? 357  ASP A O   1 
ATOM   2879 C  CB  . ASP A 1 357 ? -13.25587 40.36113 -12.37608 1.000 8.64546  ? 357  ASP A CB  1 
ATOM   2880 C  CG  . ASP A 1 357 ? -12.05048 39.46103 -12.12355 1.000 10.54180 ? 357  ASP A CG  1 
ATOM   2881 O  OD1 . ASP A 1 357 ? -11.32585 39.13295 -13.09082 1.000 10.43133 ? 357  ASP A OD1 1 
ATOM   2882 O  OD2 . ASP A 1 357 ? -11.82656 39.07468 -10.95720 1.000 10.81079 ? 357  ASP A OD2 1 
ATOM   2883 N  N   . ALA A 1 358 ? -12.86622 39.80848 -15.34777 1.000 9.25145  ? 358  ALA A N   1 
ATOM   2884 C  CA  . ALA A 1 358 ? -13.12492 39.30057 -16.69846 1.000 10.02439 ? 358  ALA A CA  1 
ATOM   2885 C  C   . ALA A 1 358 ? -12.87584 37.79655 -16.72486 1.000 8.52364  ? 358  ALA A C   1 
ATOM   2886 O  O   . ALA A 1 358 ? -11.89007 37.32160 -17.29933 1.000 9.34175  ? 358  ALA A O   1 
ATOM   2887 C  CB  . ALA A 1 358 ? -12.23704 40.02357 -17.71066 1.000 8.80172  ? 358  ALA A CB  1 
ATOM   2888 N  N   . PRO A 1 359 ? -13.76954 37.00322 -16.10635 1.000 7.66650  ? 359  PRO A N   1 
ATOM   2889 C  CA  . PRO A 1 359 ? -13.40569 35.62321 -15.74533 1.000 7.07760  ? 359  PRO A CA  1 
ATOM   2890 C  C   . PRO A 1 359 ? -13.82643 34.51998 -16.69745 1.000 7.83322  ? 359  PRO A C   1 
ATOM   2891 O  O   . PRO A 1 359 ? -13.44797 33.36331 -16.47350 1.000 8.70740  ? 359  PRO A O   1 
ATOM   2892 C  CB  . PRO A 1 359 ? -14.12139 35.43504 -14.40890 1.000 7.47806  ? 359  PRO A CB  1 
ATOM   2893 C  CG  . PRO A 1 359 ? -15.40037 36.20839 -14.60904 1.000 7.74552  ? 359  PRO A CG  1 
ATOM   2894 C  CD  . PRO A 1 359 ? -14.99121 37.44370 -15.40637 1.000 7.54465  ? 359  PRO A CD  1 
ATOM   2895 N  N   . PHE A 1 360 ? -14.61873 34.82008 -17.72109 1.000 7.46538  ? 360  PHE A N   1 
ATOM   2896 C  CA  . PHE A 1 360 ? -15.22364 33.76367 -18.51742 1.000 8.77094  ? 360  PHE A CA  1 
ATOM   2897 C  C   . PHE A 1 360 ? -14.50970 33.62328 -19.86929 1.000 7.36813  ? 360  PHE A C   1 
ATOM   2898 O  O   . PHE A 1 360 ? -13.48024 34.25639 -20.12289 1.000 9.55414  ? 360  PHE A O   1 
ATOM   2899 C  CB  . PHE A 1 360 ? -16.72239 34.03861 -18.68576 1.000 7.89864  ? 360  PHE A CB  1 
ATOM   2900 C  CG  . PHE A 1 360 ? -17.45624 34.24993 -17.38495 1.000 8.02736  ? 360  PHE A CG  1 
ATOM   2901 C  CD1 . PHE A 1 360 ? -17.44184 33.27473 -16.38584 1.000 7.20422  ? 360  PHE A CD1 1 
ATOM   2902 C  CD2 . PHE A 1 360 ? -18.19140 35.40857 -17.17677 1.000 8.77742  ? 360  PHE A CD2 1 
ATOM   2903 C  CE1 . PHE A 1 360 ? -18.13307 33.46708 -15.17818 1.000 7.03380  ? 360  PHE A CE1 1 
ATOM   2904 C  CE2 . PHE A 1 360 ? -18.90433 35.60249 -15.98538 1.000 8.05036  ? 360  PHE A CE2 1 
ATOM   2905 C  CZ  . PHE A 1 360 ? -18.86093 34.63399 -14.98006 1.000 7.44250  ? 360  PHE A CZ  1 
ATOM   2906 N  N   . VAL A 1 361 ? -15.05366 32.78086 -20.75568 1.000 7.59528  ? 361  VAL A N   1 
ATOM   2907 C  CA  . VAL A 1 361 ? -14.54467 32.68534 -22.12142 1.000 8.55203  ? 361  VAL A CA  1 
ATOM   2908 C  C   . VAL A 1 361 ? -15.32658 33.56184 -23.09313 1.000 9.00503  ? 361  VAL A C   1 
ATOM   2909 O  O   . VAL A 1 361 ? -14.95782 33.65048 -24.27241 1.000 7.56264  ? 361  VAL A O   1 
ATOM   2910 C  CB  . VAL A 1 361 ? -14.49802 31.21997 -22.62178 1.000 7.33388  ? 361  VAL A CB  1 
ATOM   2911 C  CG1 . VAL A 1 361 ? -13.72559 30.33364 -21.63289 1.000 6.89206  ? 361  VAL A CG1 1 
ATOM   2912 C  CG2 . VAL A 1 361 ? -15.90491 30.66371 -22.89697 1.000 5.45252  ? 361  VAL A CG2 1 
ATOM   2913 N  N   . PHE A 1 362 ? -16.37891 34.23205 -22.63263 1.000 7.33905  ? 362  PHE A N   1 
ATOM   2914 C  CA  . PHE A 1 362 ? -17.16511 35.13287 -23.46495 1.000 8.01827  ? 362  PHE A CA  1 
ATOM   2915 C  C   . PHE A 1 362 ? -17.05010 36.54534 -22.90497 1.000 10.63335 ? 362  PHE A C   1 
ATOM   2916 O  O   . PHE A 1 362 ? -17.21661 36.75480 -21.69195 1.000 8.81999  ? 362  PHE A O   1 
ATOM   2917 C  CB  . PHE A 1 362 ? -18.63258 34.69063 -23.51096 1.000 6.87428  ? 362  PHE A CB  1 
ATOM   2918 C  CG  . PHE A 1 362 ? -18.82825 33.25322 -23.96159 1.000 9.38984  ? 362  PHE A CG  1 
ATOM   2919 C  CD1 . PHE A 1 362 ? -18.50843 32.86951 -25.24971 1.000 6.18203  ? 362  PHE A CD1 1 
ATOM   2920 C  CD2 . PHE A 1 362 ? -19.34778 32.30229 -23.09703 1.000 8.06387  ? 362  PHE A CD2 1 
ATOM   2921 C  CE1 . PHE A 1 362 ? -18.68994 31.55179 -25.67499 1.000 8.36000  ? 362  PHE A CE1 1 
ATOM   2922 C  CE2 . PHE A 1 362 ? -19.53969 30.99468 -23.51338 1.000 7.61411  ? 362  PHE A CE2 1 
ATOM   2923 C  CZ  . PHE A 1 362 ? -19.20720 30.62098 -24.81426 1.000 8.16537  ? 362  PHE A CZ  1 
ATOM   2924 N  N   . GLY A 1 363 ? -16.77504 37.50216 -23.78532 1.000 10.11976 ? 363  GLY A N   1 
ATOM   2925 C  CA  . GLY A 1 363 ? -16.58152 38.88493 -23.39120 1.000 9.66818  ? 363  GLY A CA  1 
ATOM   2926 C  C   . GLY A 1 363 ? -17.89430 39.59376 -23.12858 1.000 10.04296 ? 363  GLY A C   1 
ATOM   2927 O  O   . GLY A 1 363 ? -18.99624 39.07038 -23.37236 1.000 9.94211  ? 363  GLY A O   1 
ATOM   2928 N  N   . PRO A 1 364 ? -17.79291 40.82659 -22.61905 1.000 10.84558 ? 364  PRO A N   1 
ATOM   2929 C  CA  . PRO A 1 364 ? -19.00153 41.53911 -22.17854 1.000 7.80650  ? 364  PRO A CA  1 
ATOM   2930 C  C   . PRO A 1 364 ? -19.90467 41.95106 -23.31743 1.000 9.27387  ? 364  PRO A C   1 
ATOM   2931 O  O   . PRO A 1 364 ? -21.07681 42.27112 -23.07236 1.000 10.94294 ? 364  PRO A O   1 
ATOM   2932 C  CB  . PRO A 1 364 ? -18.44088 42.76300 -21.44258 1.000 11.74432 ? 364  PRO A CB  1 
ATOM   2933 C  CG  . PRO A 1 364 ? -17.12686 42.99862 -22.08939 1.000 15.65661 ? 364  PRO A CG  1 
ATOM   2934 C  CD  . PRO A 1 364 ? -16.57591 41.64217 -22.45542 1.000 12.13119 ? 364  PRO A CD  1 
ATOM   2935 N  N   . ASP A 1 365 ? -19.39539 41.96774 -24.54756 1.000 10.20459 ? 365  ASP A N   1 
ATOM   2936 C  CA  . ASP A 1 365 ? -20.21109 42.17617 -25.73053 1.000 11.57500 ? 365  ASP A CA  1 
ATOM   2937 C  C   . ASP A 1 365 ? -20.64472 40.85629 -26.36109 1.000 9.43236  ? 365  ASP A C   1 
ATOM   2938 O  O   . ASP A 1 365 ? -21.04384 40.84219 -27.52555 1.000 7.57691  ? 365  ASP A O   1 
ATOM   2939 C  CB  . ASP A 1 365 ? -19.45028 43.04028 -26.74890 1.000 10.26182 ? 365  ASP A CB  1 
ATOM   2940 C  CG  . ASP A 1 365 ? -18.06123 42.48302 -27.07431 1.000 11.34936 ? 365  ASP A CG  1 
ATOM   2941 O  OD1 . ASP A 1 365 ? -17.72644 41.38692 -26.57605 1.000 9.50766  ? 365  ASP A OD1 1 
ATOM   2942 O  OD2 . ASP A 1 365 ? -17.30461 43.13388 -27.83367 1.000 9.79688  ? 365  ASP A OD2 1 
ATOM   2943 N  N   . TYR A 1 366 ? -20.54848 39.74940 -25.62271 1.000 7.63050  ? 366  TYR A N   1 
ATOM   2944 C  CA  . TYR A 1 366 ? -20.98188 38.42941 -26.10385 1.000 9.15729  ? 366  TYR A CA  1 
ATOM   2945 C  C   . TYR A 1 366 ? -20.18709 37.97046 -27.32132 1.000 10.51102 ? 366  TYR A C   1 
ATOM   2946 O  O   . TYR A 1 366 ? -20.70234 37.24203 -28.17670 1.000 12.46843 ? 366  TYR A O   1 
ATOM   2947 C  CB  . TYR A 1 366 ? -22.49355 38.40581 -26.39355 1.000 7.55193  ? 366  TYR A CB  1 
ATOM   2948 C  CG  . TYR A 1 366 ? -23.30976 38.62590 -25.13527 1.000 9.69765  ? 366  TYR A CG  1 
ATOM   2949 C  CD1 . TYR A 1 366 ? -23.65237 39.91312 -24.71386 1.000 9.44309  ? 366  TYR A CD1 1 
ATOM   2950 C  CD2 . TYR A 1 366 ? -23.69370 37.55023 -24.34112 1.000 8.30980  ? 366  TYR A CD2 1 
ATOM   2951 C  CE1 . TYR A 1 366 ? -24.38165 40.11444 -23.54137 1.000 10.31303 ? 366  TYR A CE1 1 
ATOM   2952 C  CE2 . TYR A 1 366 ? -24.41875 37.73561 -23.17323 1.000 10.71897 ? 366  TYR A CE2 1 
ATOM   2953 C  CZ  . TYR A 1 366 ? -24.76439 39.02076 -22.77781 1.000 13.10951 ? 366  TYR A CZ  1 
ATOM   2954 O  OH  . TYR A 1 366 ? -25.47668 39.20253 -21.60955 1.000 12.02860 ? 366  TYR A OH  1 
ATOM   2955 N  N   . LYS A 1 367 ? -18.92864 38.39257 -27.42351 1.000 10.53961 ? 367  LYS A N   1 
ATOM   2956 C  CA  . LYS A 1 367 ? -18.01842 37.87503 -28.43494 1.000 10.77364 ? 367  LYS A CA  1 
ATOM   2957 C  C   . LYS A 1 367 ? -16.97620 37.00387 -27.74715 1.000 10.72666 ? 367  LYS A C   1 
ATOM   2958 O  O   . LYS A 1 367 ? -16.67615 37.20100 -26.56661 1.000 11.90549 ? 367  LYS A O   1 
ATOM   2959 C  CB  . LYS A 1 367 ? -17.35451 39.01665 -29.21534 1.000 10.79544 ? 367  LYS A CB  1 
ATOM   2960 C  CG  . LYS A 1 367 ? -18.36256 39.88053 -29.96839 1.000 8.86690  ? 367  LYS A CG  1 
ATOM   2961 C  CD  . LYS A 1 367 ? -17.73862 41.17212 -30.47560 1.000 12.28768 ? 367  LYS A CD  1 
ATOM   2962 C  CE  . LYS A 1 367 ? -18.71774 41.97544 -31.34225 1.000 12.60906 ? 367  LYS A CE  1 
ATOM   2963 N  NZ  . LYS A 1 367 ? -18.24672 43.38193 -31.56491 1.000 11.93304 ? 367  LYS A NZ  1 
ATOM   2964 N  N   . VAL A 1 368 ? -16.42192 36.03031 -28.48320 1.000 9.88735  ? 368  VAL A N   1 
ATOM   2965 C  CA  . VAL A 1 368 ? -15.57487 35.02151 -27.85356 1.000 8.09888  ? 368  VAL A CA  1 
ATOM   2966 C  C   . VAL A 1 368 ? -14.19854 35.60292 -27.55518 1.000 9.59914  ? 368  VAL A C   1 
ATOM   2967 O  O   . VAL A 1 368 ? -13.65155 36.40876 -28.32269 1.000 8.37857  ? 368  VAL A O   1 
ATOM   2968 C  CB  . VAL A 1 368 ? -15.48154 33.75449 -28.72466 1.000 9.09778  ? 368  VAL A CB  1 
ATOM   2969 C  CG1 . VAL A 1 368 ? -16.87192 33.11263 -28.87870 1.000 7.41344  ? 368  VAL A CG1 1 
ATOM   2970 C  CG2 . VAL A 1 368 ? -14.87136 34.07328 -30.08895 1.000 8.37213  ? 368  VAL A CG2 1 
ATOM   2971 N  N   . LYS A 1 369 ? -13.64339 35.19498 -26.42283 1.000 9.59365  ? 369  LYS A N   1 
ATOM   2972 C  CA  . LYS A 1 369 ? -12.33469 35.63192 -25.96304 1.000 10.25148 ? 369  LYS A CA  1 
ATOM   2973 C  C   . LYS A 1 369 ? -11.27952 34.63492 -26.41476 1.000 8.47902  ? 369  LYS A C   1 
ATOM   2974 O  O   . LYS A 1 369 ? -11.59766 33.54910 -26.90378 1.000 8.58700  ? 369  LYS A O   1 
ATOM   2975 C  CB  . LYS A 1 369 ? -12.35234 35.76624 -24.43590 1.000 7.68461  ? 369  LYS A CB  1 
ATOM   2976 C  CG  . LYS A 1 369 ? -13.34967 36.79652 -23.92766 1.000 8.66369  ? 369  LYS A CG  1 
ATOM   2977 C  CD  . LYS A 1 369 ? -13.60461 36.63436 -22.43914 1.000 8.41510  ? 369  LYS A CD  1 
ATOM   2978 C  CE  . LYS A 1 369 ? -12.32504 36.85729 -21.62824 1.000 8.25082  ? 369  LYS A CE  1 
ATOM   2979 N  NZ  . LYS A 1 369 ? -12.59177 36.68289 -20.16589 1.000 6.65134  ? 369  LYS A NZ  1 
ATOM   2980 N  N   . PRO A 1 370 ? -9.99487  34.96521 -26.28185 1.000 10.92767 ? 370  PRO A N   1 
ATOM   2981 C  CA  . PRO A 1 370 ? -8.97793  33.94390 -26.56066 1.000 10.27797 ? 370  PRO A CA  1 
ATOM   2982 C  C   . PRO A 1 370 ? -9.14442  32.70254 -25.69647 1.000 10.43749 ? 370  PRO A C   1 
ATOM   2983 O  O   . PRO A 1 370 ? -8.80692  31.60508 -26.15219 1.000 10.41777 ? 370  PRO A O   1 
ATOM   2984 C  CB  . PRO A 1 370 ? -7.65346  34.66885 -26.27869 1.000 11.98748 ? 370  PRO A CB  1 
ATOM   2985 C  CG  . PRO A 1 370 ? -7.97088  36.11260 -26.46114 1.000 13.60959 ? 370  PRO A CG  1 
ATOM   2986 C  CD  . PRO A 1 370 ? -9.39752  36.29297 -26.02681 1.000 11.08191 ? 370  PRO A CD  1 
ATOM   2987 N  N   . ALA A 1 371 ? -9.68136  32.83695 -24.47685 1.000 8.67613  ? 371  ALA A N   1 
ATOM   2988 C  CA  . ALA A 1 371 ? -9.91626  31.66302 -23.63873 1.000 8.56910  ? 371  ALA A CA  1 
ATOM   2989 C  C   . ALA A 1 371 ? -10.89901 30.69710 -24.29022 1.000 10.91277 ? 371  ALA A C   1 
ATOM   2990 O  O   . ALA A 1 371 ? -10.76764 29.47538 -24.13766 1.000 9.28661  ? 371  ALA A O   1 
ATOM   2991 C  CB  . ALA A 1 371 ? -10.42477 32.07526 -22.25130 1.000 7.99024  ? 371  ALA A CB  1 
ATOM   2992 N  N   . TYR A 1 372 ? -11.89574 31.22416 -25.00840 1.000 6.57183  ? 372  TYR A N   1 
ATOM   2993 C  CA  . TYR A 1 372 ? -12.81608 30.37163 -25.75982 1.000 9.52585  ? 372  TYR A CA  1 
ATOM   2994 C  C   . TYR A 1 372 ? -12.06629 29.50083 -26.76834 1.000 11.09978 ? 372  TYR A C   1 
ATOM   2995 O  O   . TYR A 1 372 ? -12.21355 28.27291 -26.78635 1.000 8.51604  ? 372  TYR A O   1 
ATOM   2996 C  CB  . TYR A 1 372 ? -13.87118 31.22988 -26.47723 1.000 6.43198  ? 372  TYR A CB  1 
ATOM   2997 C  CG  . TYR A 1 372 ? -14.67970 30.44263 -27.49959 1.000 7.39036  ? 372  TYR A CG  1 
ATOM   2998 C  CD1 . TYR A 1 372 ? -15.78553 29.69553 -27.11242 1.000 8.82580  ? 372  TYR A CD1 1 
ATOM   2999 C  CD2 . TYR A 1 372 ? -14.31795 30.42767 -28.83995 1.000 10.09119 ? 372  TYR A CD2 1 
ATOM   3000 C  CE1 . TYR A 1 372 ? -16.51763 28.96195 -28.04110 1.000 8.78260  ? 372  TYR A CE1 1 
ATOM   3001 C  CE2 . TYR A 1 372 ? -15.02760 29.69830 -29.76515 1.000 9.98395  ? 372  TYR A CE2 1 
ATOM   3002 C  CZ  . TYR A 1 372 ? -16.12034 28.96482 -29.36627 1.000 9.72004  ? 372  TYR A CZ  1 
ATOM   3003 O  OH  . TYR A 1 372 ? -16.82376 28.24605 -30.29836 1.000 10.02992 ? 372  TYR A OH  1 
ATOM   3004 N  N   . TRP A 1 373 ? -11.29498 30.13057 -27.65928 1.000 9.17115  ? 373  TRP A N   1 
ATOM   3005 C  CA  . TRP A 1 373 ? -10.54691 29.35881 -28.64961 1.000 10.86170 ? 373  TRP A CA  1 
ATOM   3006 C  C   . TRP A 1 373 ? -9.63874  28.34314 -27.96995 1.000 12.12070 ? 373  TRP A C   1 
ATOM   3007 O  O   . TRP A 1 373 ? -9.46693  27.22140 -28.46248 1.000 12.54209 ? 373  TRP A O   1 
ATOM   3008 C  CB  . TRP A 1 373 ? -9.74869  30.29980 -29.55990 1.000 11.53661 ? 373  TRP A CB  1 
ATOM   3009 C  CG  . TRP A 1 373 ? -10.65167 31.16777 -30.41249 1.000 14.22447 ? 373  TRP A CG  1 
ATOM   3010 C  CD1 . TRP A 1 373 ? -10.76556 32.54076 -30.36820 1.000 12.42346 ? 373  TRP A CD1 1 
ATOM   3011 C  CD2 . TRP A 1 373 ? -11.59281 30.72133 -31.39871 1.000 13.73067 ? 373  TRP A CD2 1 
ATOM   3012 N  NE1 . TRP A 1 373 ? -11.70777 32.96474 -31.27712 1.000 10.78295 ? 373  TRP A NE1 1 
ATOM   3013 C  CE2 . TRP A 1 373 ? -12.23511 31.87224 -31.91684 1.000 11.28432 ? 373  TRP A CE2 1 
ATOM   3014 C  CE3 . TRP A 1 373 ? -11.95241 29.46191 -31.90062 1.000 14.97427 ? 373  TRP A CE3 1 
ATOM   3015 C  CZ2 . TRP A 1 373 ? -13.20143 31.80407 -32.91435 1.000 10.33609 ? 373  TRP A CZ2 1 
ATOM   3016 C  CZ3 . TRP A 1 373 ? -12.92419 29.39392 -32.89996 1.000 15.57627 ? 373  TRP A CZ3 1 
ATOM   3017 C  CH2 . TRP A 1 373 ? -13.54057 30.56315 -33.39265 1.000 15.72702 ? 373  TRP A CH2 1 
ATOM   3018 N  N   . ALA A 1 374 ? -9.08634  28.70601 -26.81071 1.000 10.31680 ? 374  ALA A N   1 
ATOM   3019 C  CA  . ALA A 1 374 ? -8.22318  27.79199 -26.07896 1.000 13.21271 ? 374  ALA A CA  1 
ATOM   3020 C  C   . ALA A 1 374 ? -8.95820  26.53290 -25.62571 1.000 13.61346 ? 374  ALA A C   1 
ATOM   3021 O  O   . ALA A 1 374 ? -8.33482  25.47751 -25.49457 1.000 11.38840 ? 374  ALA A O   1 
ATOM   3022 C  CB  . ALA A 1 374 ? -7.60619  28.49693 -24.87182 1.000 9.80679  ? 374  ALA A CB  1 
ATOM   3023 N  N   . ILE A 1 375 ? -10.26114 26.59542 -25.36043 1.000 9.50511  ? 375  ILE A N   1 
ATOM   3024 C  CA  . ILE A 1 375 ? -10.94088 25.39699 -24.86263 1.000 10.18967 ? 375  ILE A CA  1 
ATOM   3025 C  C   . ILE A 1 375 ? -11.86141 24.76784 -25.88746 1.000 8.16669  ? 375  ILE A C   1 
ATOM   3026 O  O   . ILE A 1 375 ? -12.29653 23.62006 -25.68388 1.000 9.23104  ? 375  ILE A O   1 
ATOM   3027 C  CB  . ILE A 1 375 ? -11.69828 25.65836 -23.53765 1.000 8.88059  ? 375  ILE A CB  1 
ATOM   3028 C  CG1 . ILE A 1 375 ? -12.91602 26.56714 -23.73605 1.000 10.24390 ? 375  ILE A CG1 1 
ATOM   3029 C  CG2 . ILE A 1 375 ? -10.74741 26.20657 -22.45449 1.000 5.83232  ? 375  ILE A CG2 1 
ATOM   3030 C  CD1 . ILE A 1 375 ? -13.80388 26.64392 -22.49385 1.000 10.79031 ? 375  ILE A CD1 1 
ATOM   3031 N  N   . ILE A 1 376 ? -12.14196 25.44785 -26.99866 1.000 9.53969  ? 376  ILE A N   1 
ATOM   3032 C  CA  . ILE A 1 376 ? -12.97890 24.84272 -28.02500 1.000 10.15820 ? 376  ILE A CA  1 
ATOM   3033 C  C   . ILE A 1 376 ? -12.17631 23.90341 -28.91318 1.000 12.93554 ? 376  ILE A C   1 
ATOM   3034 O  O   . ILE A 1 376 ? -12.75907 23.00451 -29.52285 1.000 12.39943 ? 376  ILE A O   1 
ATOM   3035 C  CB  . ILE A 1 376 ? -13.68809 25.91113 -28.87861 1.000 9.53032  ? 376  ILE A CB  1 
ATOM   3036 C  CG1 . ILE A 1 376 ? -14.95321 25.33582 -29.53929 1.000 13.20632 ? 376  ILE A CG1 1 
ATOM   3037 C  CG2 . ILE A 1 376 ? -12.74879 26.48347 -29.94041 1.000 10.34666 ? 376  ILE A CG2 1 
ATOM   3038 C  CD1 . ILE A 1 376 ? -16.08163 25.01507 -28.55089 1.000 8.78288  ? 376  ILE A CD1 1 
ATOM   3039 N  N   . ASP A 1 377 ? -10.85585 24.07250 -28.99380 1.000 12.50682 ? 377  ASP A N   1 
ATOM   3040 C  CA  . ASP A 1 377 ? -10.05258 23.27364 -29.90263 1.000 13.09929 ? 377  ASP A CA  1 
ATOM   3041 C  C   . ASP A 1 377 ? -9.71526  21.92186 -29.26243 1.000 16.36447 ? 377  ASP A C   1 
ATOM   3042 O  O   . ASP A 1 377 ? -10.16850 21.59132 -28.15999 1.000 10.47442 ? 377  ASP A O   1 
ATOM   3043 C  CB  . ASP A 1 377 ? -8.81004  24.05712 -30.33973 1.000 15.20530 ? 377  ASP A CB  1 
ATOM   3044 C  CG  . ASP A 1 377 ? -7.78724  24.26501 -29.21722 1.000 18.85056 ? 377  ASP A CG  1 
ATOM   3045 O  OD1 . ASP A 1 377 ? -7.94991  23.72444 -28.11046 1.000 17.40217 ? 377  ASP A OD1 1 
ATOM   3046 O  OD2 . ASP A 1 377 ? -6.79780  24.99207 -29.44796 1.000 18.61959 ? 377  ASP A OD2 1 
ATOM   3047 N  N   . HIS A 1 378 ? -8.90999  21.11580 -29.95950 1.000 12.80251 ? 378  HIS A N   1 
ATOM   3048 C  CA  . HIS A 1 378 ? -8.52802  19.80212 -29.44915 1.000 19.93768 ? 378  HIS A CA  1 
ATOM   3049 C  C   . HIS A 1 378 ? -7.01856  19.69583 -29.28352 1.000 22.24862 ? 378  HIS A C   1 
ATOM   3050 O  O   . HIS A 1 378 ? -6.44727  18.61267 -29.43077 1.000 22.67459 ? 378  HIS A O   1 
ATOM   3051 C  CB  . HIS A 1 378 ? -9.05242  18.67374 -30.34483 1.000 17.70581 ? 378  HIS A CB  1 
ATOM   3052 C  CG  . HIS A 1 378 ? -10.53658 18.68141 -30.50844 1.000 17.94469 ? 378  HIS A CG  1 
ATOM   3053 N  ND1 . HIS A 1 378 ? -11.37734 17.89611 -29.74584 1.000 15.82342 ? 378  HIS A ND1 1 
ATOM   3054 C  CD2 . HIS A 1 378 ? -11.33391 19.40587 -31.32566 1.000 14.97414 ? 378  HIS A CD2 1 
ATOM   3055 C  CE1 . HIS A 1 378 ? -12.62920 18.13026 -30.09608 1.000 20.08894 ? 378  HIS A CE1 1 
ATOM   3056 N  NE2 . HIS A 1 378 ? -12.63041 19.04550 -31.04895 1.000 18.52408 ? 378  HIS A NE2 1 
ATOM   3057 N  N   . LYS A 1 379 ? -6.37003  20.81514 -28.98357 1.000 20.91049 ? 379  LYS A N   1 
ATOM   3058 C  CA  . LYS A 1 379 ? -4.93276  20.84225 -28.72389 1.000 23.87521 ? 379  LYS A CA  1 
ATOM   3059 C  C   . LYS A 1 379 ? -4.69549  21.25000 -27.28315 1.000 30.89943 ? 379  LYS A C   1 
ATOM   3060 O  O   . LYS A 1 379 ? -5.62406  21.69482 -26.60997 1.000 21.96289 ? 379  LYS A O   1 
ATOM   3061 C  CB  . LYS A 1 379 ? -4.20854  21.81736 -29.65245 1.000 23.87585 ? 379  LYS A CB  1 
ATOM   3062 C  CG  . LYS A 1 379 ? -4.71462  21.82971 -31.07461 1.000 36.73619 ? 379  LYS A CG  1 
ATOM   3063 C  CD  . LYS A 1 379 ? -3.97691  22.86735 -31.91453 1.000 40.08519 ? 379  LYS A CD  1 
ATOM   3064 C  CE  . LYS A 1 379 ? -4.18105  24.28402 -31.36741 1.000 51.35622 ? 379  LYS A CE  1 
ATOM   3065 N  NZ  . LYS A 1 379 ? -5.45582  24.93234 -31.82625 1.000 43.66472 ? 379  LYS A NZ  1 
ATOM   3066 O  OXT . LYS A 1 379 ? -3.57907  21.16041 -26.77125 1.000 37.46445 ? 379  LYS A OXT 1 
HETATM 3067 ZN ZN  . ZN  B 2 .   ? -25.28671 38.10063 -10.50008 1.000 13.79373 ? 401  ZN  A ZN  1 
HETATM 3068 ZN ZN  . ZN  C 2 .   ? -17.59254 12.82351 -17.13177 1.000 49.05740 ? 402  ZN  A ZN  1 
HETATM 3069 ZN ZN  . ZN  D 2 .   ? -15.84769 50.68393 -20.94536 1.000 41.94148 ? 403  ZN  A ZN  1 
HETATM 3070 ZN ZN  . ZN  E 2 .   ? -6.94790  23.65451 -25.81496 1.000 29.66111 ? 404  ZN  A ZN  1 
HETATM 3071 ZN ZN  . ZN  F 2 .   ? -26.79094 22.23571 -26.39497 1.000 12.74623 ? 405  ZN  A ZN  1 
HETATM 3072 ZN ZN  . ZN  G 2 .   ? -14.47586 12.05500 -25.59082 1.000 12.18279 ? 406  ZN  A ZN  1 
HETATM 3073 CL CL  . CL  H 3 .   ? -23.51650 38.64101 -9.32953  1.000 14.21274 ? 407  CL  A CL  1 
HETATM 3074 CL CL  . CL  I 3 .   ? -15.31368 12.28140 -27.69967 1.000 12.06278 ? 408  CL  A CL  1 
HETATM 3075 O  O   . HOH J 4 .   ? -29.21664 36.39822 23.34651  1.000 47.99931 ? 501  HOH A O   1 
HETATM 3076 O  O   . HOH J 4 .   ? -37.18239 12.93524 8.20147   1.000 37.58711 ? 502  HOH A O   1 
HETATM 3077 O  O   . HOH J 4 .   ? -30.18043 33.80303 25.67136  1.000 41.20257 ? 503  HOH A O   1 
HETATM 3078 O  O   . HOH J 4 .   ? -34.13572 6.17012  -0.67795  1.000 37.14519 ? 504  HOH A O   1 
HETATM 3079 O  O   . HOH J 4 .   ? -25.14472 17.73918 -15.57581 1.000 21.22957 ? 505  HOH A O   1 
HETATM 3080 O  O   . HOH J 4 .   ? -40.73505 18.31238 8.51452   1.000 26.86484 ? 506  HOH A O   1 
HETATM 3081 O  O   . HOH J 4 .   ? -7.08779  49.34060 2.19245   1.000 32.44063 ? 507  HOH A O   1 
HETATM 3082 O  O   . HOH J 4 .   ? -35.41443 10.53137 -6.73851  1.000 29.99298 ? 508  HOH A O   1 
HETATM 3083 O  O   . HOH J 4 .   ? -24.56627 12.26742 -13.53923 1.000 34.55265 ? 509  HOH A O   1 
HETATM 3084 O  O   . HOH J 4 .   ? -33.28341 29.61364 24.33346  1.000 25.30957 ? 510  HOH A O   1 
HETATM 3085 O  O   . HOH J 4 .   ? -44.43560 33.71793 0.00000   0.50  24.42127 ? 511  HOH A O   1 
HETATM 3086 O  O   . HOH J 4 .   ? -1.44256  47.76554 -15.99213 1.000 24.61877 ? 512  HOH A O   1 
HETATM 3087 O  O   . HOH J 4 .   ? -31.86636 37.40906 -7.86387  1.000 28.94070 ? 513  HOH A O   1 
HETATM 3088 O  O   . HOH J 4 .   ? -4.53073  11.74293 -12.84042 1.000 19.37115 ? 514  HOH A O   1 
HETATM 3089 O  O   . HOH J 4 .   ? -40.288   35.715   -5.203    1.000 46.87388 ? 515  HOH A O   1 
HETATM 3090 O  O   . HOH J 4 .   ? -26.17660 13.37961 17.99902  1.000 40.77584 ? 516  HOH A O   1 
HETATM 3091 O  O   . HOH J 4 .   ? -19.52615 30.92510 -2.08489  1.000 29.24745 ? 517  HOH A O   1 
HETATM 3092 O  O   . HOH J 4 .   ? -14.58332 4.80659  4.49829   1.000 35.24178 ? 518  HOH A O   1 
HETATM 3093 O  O   . HOH J 4 .   ? -2.57324  32.29841 -24.68062 1.000 22.34275 ? 519  HOH A O   1 
HETATM 3094 O  O   . HOH J 4 .   ? -3.01096  22.48872 -2.54073  1.000 26.61908 ? 520  HOH A O   1 
HETATM 3095 O  O   . HOH J 4 .   ? -8.60420  7.25522  3.42132   1.000 39.86097 ? 521  HOH A O   1 
HETATM 3096 O  O   . HOH J 4 .   ? -12.64817 52.97067 -8.99391  1.000 16.37266 ? 522  HOH A O   1 
HETATM 3097 O  O   . HOH J 4 .   ? -42.82309 13.40992 0.49188   1.000 22.51016 ? 523  HOH A O   1 
HETATM 3098 O  O   . HOH J 4 .   ? -22.62013 30.06109 -2.67521  1.000 26.71788 ? 524  HOH A O   1 
HETATM 3099 O  O   . HOH J 4 .   ? -26.77750 41.34599 -16.92591 1.000 29.29585 ? 525  HOH A O   1 
HETATM 3100 O  O   . HOH J 4 .   ? -33.46793 2.76392  -5.63151  1.000 47.93137 ? 526  HOH A O   1 
HETATM 3101 O  O   . HOH J 4 .   ? -37.09985 21.69415 20.71182  1.000 34.38865 ? 527  HOH A O   1 
HETATM 3102 O  O   . HOH J 4 .   ? -15.04763 10.39824 -19.43142 1.000 22.92531 ? 528  HOH A O   1 
HETATM 3103 O  O   . HOH J 4 .   ? -18.69461 25.55368 18.39558  1.000 29.16775 ? 529  HOH A O   1 
HETATM 3104 O  O   . HOH J 4 .   ? -15.72927 26.93457 3.44861   1.000 10.37997 ? 530  HOH A O   1 
HETATM 3105 O  O   . HOH J 4 .   ? 0.05454   27.13465 -20.89003 1.000 21.46844 ? 531  HOH A O   1 
HETATM 3106 O  O   . HOH J 4 .   ? -44.43560 19.75340 0.00000   0.50  8.21164  ? 532  HOH A O   1 
HETATM 3107 O  O   . HOH J 4 .   ? -9.60963  44.93913 -21.83999 1.000 20.65434 ? 533  HOH A O   1 
HETATM 3108 O  O   . HOH J 4 .   ? -26.86287 38.97645 -9.66714  1.000 10.23954 ? 534  HOH A O   1 
HETATM 3109 O  O   . HOH J 4 .   ? -1.96160  43.54890 -15.65499 1.000 33.60620 ? 535  HOH A O   1 
HETATM 3110 O  O   . HOH J 4 .   ? -0.68945  22.11632 -16.31153 1.000 28.62973 ? 536  HOH A O   1 
HETATM 3111 O  O   . HOH J 4 .   ? -7.10599  55.68419 2.63858   1.000 34.41368 ? 537  HOH A O   1 
HETATM 3112 O  O   . HOH J 4 .   ? -29.05404 30.40279 -29.40143 1.000 22.62945 ? 538  HOH A O   1 
HETATM 3113 O  O   . HOH J 4 .   ? -39.16373 23.04422 -25.29789 1.000 35.94659 ? 539  HOH A O   1 
HETATM 3114 O  O   . HOH J 4 .   ? -44.12516 29.70433 -10.19324 1.000 18.44888 ? 540  HOH A O   1 
HETATM 3115 O  O   . HOH J 4 .   ? -1.20708  16.09098 -9.33725  1.000 18.04848 ? 541  HOH A O   1 
HETATM 3116 O  O   . HOH J 4 .   ? -12.02551 43.58823 -0.20683  1.000 19.07781 ? 542  HOH A O   1 
HETATM 3117 O  O   . HOH J 4 .   ? -3.86490  43.34192 -9.70430  1.000 12.70038 ? 543  HOH A O   1 
HETATM 3118 O  O   . HOH J 4 .   ? -27.44712 24.04769 -25.50826 1.000 7.50622  ? 544  HOH A O   1 
HETATM 3119 O  O   . HOH J 4 .   ? -27.74862 28.37172 32.64434  1.000 42.43044 ? 545  HOH A O   1 
HETATM 3120 O  O   . HOH J 4 .   ? -37.16056 32.92816 -21.47086 1.000 22.91281 ? 546  HOH A O   1 
HETATM 3121 O  O   . HOH J 4 .   ? -23.10819 43.73136 -23.68340 1.000 19.32735 ? 547  HOH A O   1 
HETATM 3122 O  O   . HOH J 4 .   ? -31.23962 32.28276 23.60543  1.000 31.99438 ? 548  HOH A O   1 
HETATM 3123 O  O   . HOH J 4 .   ? -1.49758  43.02779 -2.21962  1.000 36.94666 ? 549  HOH A O   1 
HETATM 3124 O  O   . HOH J 4 .   ? -11.17722 52.77377 -18.97372 1.000 26.68458 ? 550  HOH A O   1 
HETATM 3125 O  O   . HOH J 4 .   ? -13.71630 22.24351 -31.80131 1.000 22.93851 ? 551  HOH A O   1 
HETATM 3126 O  O   . HOH J 4 .   ? -22.29801 26.17319 8.24379   1.000 16.04231 ? 552  HOH A O   1 
HETATM 3127 O  O   . HOH J 4 .   ? -32.80417 9.56581  4.66229   1.000 19.79157 ? 553  HOH A O   1 
HETATM 3128 O  O   . HOH J 4 .   ? -25.29380 19.43636 -14.23724 1.000 21.96103 ? 554  HOH A O   1 
HETATM 3129 O  O   . HOH J 4 .   ? -6.82401  18.83450 7.28626   1.000 29.53541 ? 555  HOH A O   1 
HETATM 3130 O  O   . HOH J 4 .   ? -23.09302 36.38106 -16.22149 1.000 8.49868  ? 556  HOH A O   1 
HETATM 3131 O  O   . HOH J 4 .   ? -40.32994 26.20204 14.08713  1.000 21.58881 ? 557  HOH A O   1 
HETATM 3132 O  O   . HOH J 4 .   ? -23.82934 12.36988 15.36453  1.000 42.51100 ? 558  HOH A O   1 
HETATM 3133 O  O   . HOH J 4 .   ? -28.02120 34.50539 13.52530  1.000 31.99119 ? 559  HOH A O   1 
HETATM 3134 O  O   . HOH J 4 .   ? -26.26365 38.92438 -18.47561 1.000 13.02361 ? 560  HOH A O   1 
HETATM 3135 O  O   . HOH J 4 .   ? -23.13051 7.71502  -4.68458  1.000 32.46857 ? 561  HOH A O   1 
HETATM 3136 O  O   . HOH J 4 .   ? -16.63308 7.48919  -15.06047 1.000 26.58845 ? 562  HOH A O   1 
HETATM 3137 O  O   . HOH J 4 .   ? -21.48485 11.26183 -28.41697 1.000 23.30352 ? 563  HOH A O   1 
HETATM 3138 O  O   . HOH J 4 .   ? -14.65409 44.08242 -2.03454  1.000 15.41256 ? 564  HOH A O   1 
HETATM 3139 O  O   . HOH J 4 .   ? -19.81572 12.19278 -29.65964 1.000 23.56874 ? 565  HOH A O   1 
HETATM 3140 O  O   . HOH J 4 .   ? -5.47059  25.19628 -27.19725 1.000 17.82601 ? 566  HOH A O   1 
HETATM 3141 O  O   . HOH J 4 .   ? -3.87462  14.42831 3.23465   1.000 24.02256 ? 567  HOH A O   1 
HETATM 3142 O  O   . HOH J 4 .   ? -29.00402 26.99636 22.01470  1.000 26.42996 ? 568  HOH A O   1 
HETATM 3143 O  O   . HOH J 4 .   ? -4.80903  49.98570 -17.82858 1.000 16.82277 ? 569  HOH A O   1 
HETATM 3144 O  O   . HOH J 4 .   ? -19.36531 45.51785 -13.05507 1.000 22.48030 ? 570  HOH A O   1 
HETATM 3145 O  O   . HOH J 4 .   ? -0.65140  25.03153 -12.61860 1.000 30.96979 ? 571  HOH A O   1 
HETATM 3146 O  O   . HOH J 4 .   ? -11.36248 30.73265 -4.05136  1.000 14.07907 ? 572  HOH A O   1 
HETATM 3147 O  O   . HOH J 4 .   ? -6.97128  11.60936 5.70246   1.000 36.12992 ? 573  HOH A O   1 
HETATM 3148 O  O   . HOH J 4 .   ? -11.537   14.272   -23.952   1.000 14.40218 ? 574  HOH A O   1 
HETATM 3149 O  O   . HOH J 4 .   ? 0.71483   33.86818 -21.32807 1.000 28.20558 ? 575  HOH A O   1 
HETATM 3150 O  O   . HOH J 4 .   ? -1.58812  37.38536 -15.56707 1.000 25.71346 ? 576  HOH A O   1 
HETATM 3151 O  O   . HOH J 4 .   ? 2.11095   20.41103 -6.03471  1.000 21.06986 ? 577  HOH A O   1 
HETATM 3152 O  O   . HOH J 4 .   ? -24.41763 17.30568 16.56930  1.000 22.43234 ? 578  HOH A O   1 
HETATM 3153 O  O   . HOH J 4 .   ? -42.96413 17.13529 -7.03194  1.000 29.72358 ? 579  HOH A O   1 
HETATM 3154 O  O   . HOH J 4 .   ? -19.84453 23.63970 10.05596  1.000 15.94485 ? 580  HOH A O   1 
HETATM 3155 O  O   . HOH J 4 .   ? -25.65642 23.32986 -27.84540 1.000 8.66245  ? 581  HOH A O   1 
HETATM 3156 O  O   . HOH J 4 .   ? -10.73962 16.07013 -27.94066 1.000 27.86367 ? 582  HOH A O   1 
HETATM 3157 O  O   . HOH J 4 .   ? -24.91772 32.43641 9.57858   1.000 29.22145 ? 583  HOH A O   1 
HETATM 3158 O  O   . HOH J 4 .   ? -15.37761 10.43827 -9.48179  1.000 20.08260 ? 584  HOH A O   1 
HETATM 3159 O  O   . HOH J 4 .   ? -8.62782  44.10791 -2.40051  1.000 14.38452 ? 585  HOH A O   1 
HETATM 3160 O  O   . HOH J 4 .   ? 2.01089   52.80028 -6.41438  1.000 20.56785 ? 586  HOH A O   1 
HETATM 3161 O  O   . HOH J 4 .   ? -27.08702 20.67142 25.60395  1.000 34.77173 ? 587  HOH A O   1 
HETATM 3162 O  O   . HOH J 4 .   ? 0.53251   47.91172 -0.93712  1.000 28.21574 ? 588  HOH A O   1 
HETATM 3163 O  O   . HOH J 4 .   ? -13.52328 26.65968 10.97079  1.000 21.24070 ? 589  HOH A O   1 
HETATM 3164 O  O   . HOH J 4 .   ? -3.46714  20.31174 -18.20176 1.000 16.25890 ? 590  HOH A O   1 
HETATM 3165 O  O   . HOH J 4 .   ? -8.89612  35.44617 -30.12452 1.000 20.83760 ? 591  HOH A O   1 
HETATM 3166 O  O   . HOH J 4 .   ? -29.22654 30.27732 -5.72552  1.000 9.22120  ? 592  HOH A O   1 
HETATM 3167 O  O   . HOH J 4 .   ? -14.61976 25.37723 14.44458  1.000 25.16020 ? 593  HOH A O   1 
HETATM 3168 O  O   . HOH J 4 .   ? -18.53045 39.30562 -2.66482  1.000 15.94266 ? 594  HOH A O   1 
HETATM 3169 O  O   . HOH J 4 .   ? -17.65965 46.86040 -9.88294  1.000 17.66500 ? 595  HOH A O   1 
HETATM 3170 O  O   . HOH J 4 .   ? -39.89823 31.87899 12.79523  1.000 16.35209 ? 596  HOH A O   1 
HETATM 3171 O  O   . HOH J 4 .   ? -10.62609 55.25839 -12.34177 1.000 21.65538 ? 597  HOH A O   1 
HETATM 3172 O  O   . HOH J 4 .   ? -43.79954 19.66869 -7.90573  1.000 28.56897 ? 598  HOH A O   1 
HETATM 3173 O  O   . HOH J 4 .   ? -6.77534  15.94459 -21.79817 1.000 13.80204 ? 599  HOH A O   1 
HETATM 3174 O  O   . HOH J 4 .   ? -27.55469 40.91330 -22.25946 1.000 23.10330 ? 600  HOH A O   1 
HETATM 3175 O  O   . HOH J 4 .   ? -29.91762 26.42178 -8.27532  1.000 7.57166  ? 601  HOH A O   1 
HETATM 3176 O  O   . HOH J 4 .   ? -5.54420  35.74803 -11.64812 1.000 12.09383 ? 602  HOH A O   1 
HETATM 3177 O  O   . HOH J 4 .   ? -8.92906  8.74580  -7.79260  1.000 23.82249 ? 603  HOH A O   1 
HETATM 3178 O  O   . HOH J 4 .   ? -38.75875 33.65965 -17.14751 1.000 20.16610 ? 604  HOH A O   1 
HETATM 3179 O  O   . HOH J 4 .   ? -21.43891 9.24866  -6.67725  1.000 27.18947 ? 605  HOH A O   1 
HETATM 3180 O  O   . HOH J 4 .   ? -6.50672  48.37299 -8.07576  1.000 9.26344  ? 606  HOH A O   1 
HETATM 3181 O  O   . HOH J 4 .   ? -13.30612 52.82147 -21.41907 1.000 27.63384 ? 607  HOH A O   1 
HETATM 3182 O  O   . HOH J 4 .   ? -34.44624 19.54227 -17.67489 1.000 22.64849 ? 608  HOH A O   1 
HETATM 3183 O  O   . HOH J 4 .   ? 0.00000   14.23222 0.00000   0.50  30.15644 ? 609  HOH A O   1 
HETATM 3184 O  O   . HOH J 4 .   ? -33.51710 19.26611 26.39985  1.000 34.53232 ? 610  HOH A O   1 
HETATM 3185 O  O   . HOH J 4 .   ? -27.93031 24.35024 21.08396  1.000 21.22843 ? 611  HOH A O   1 
HETATM 3186 O  O   . HOH J 4 .   ? -38.34401 25.31180 7.74558   1.000 13.00101 ? 612  HOH A O   1 
HETATM 3187 O  O   . HOH J 4 .   ? -9.87570  27.30558 -5.41082  1.000 21.27369 ? 613  HOH A O   1 
HETATM 3188 O  O   . HOH J 4 .   ? -42.88966 33.46214 9.89129   1.000 17.57908 ? 614  HOH A O   1 
HETATM 3189 O  O   . HOH J 4 .   ? -24.99741 23.93464 -13.71724 1.000 9.95774  ? 615  HOH A O   1 
HETATM 3190 O  O   . HOH J 4 .   ? -44.09953 22.51980 3.99189   1.000 10.46284 ? 616  HOH A O   1 
HETATM 3191 O  O   . HOH J 4 .   ? -28.61948 14.59132 -18.21212 1.000 45.68648 ? 617  HOH A O   1 
HETATM 3192 O  O   . HOH J 4 .   ? -18.31372 34.74581 -11.90313 1.000 8.42591  ? 618  HOH A O   1 
HETATM 3193 O  O   . HOH J 4 .   ? -35.44229 36.77485 0.27356   1.000 24.26513 ? 619  HOH A O   1 
HETATM 3194 O  O   . HOH J 4 .   ? -37.82498 32.20769 14.43275  1.000 19.02165 ? 620  HOH A O   1 
HETATM 3195 O  O   . HOH J 4 .   ? -43.36379 21.65121 -1.76643  1.000 11.85000 ? 621  HOH A O   1 
HETATM 3196 O  O   . HOH J 4 .   ? -20.83984 27.03055 -6.98778  1.000 13.59049 ? 622  HOH A O   1 
HETATM 3197 O  O   . HOH J 4 .   ? -23.13721 6.71740  2.58710   1.000 31.14522 ? 623  HOH A O   1 
HETATM 3198 O  O   . HOH J 4 .   ? -21.98195 27.12650 5.65180   1.000 13.57489 ? 624  HOH A O   1 
HETATM 3199 O  O   . HOH J 4 .   ? -24.22907 21.30955 -34.10621 1.000 23.73665 ? 625  HOH A O   1 
HETATM 3200 O  O   . HOH J 4 .   ? -37.02756 37.93103 17.99696  1.000 33.41326 ? 626  HOH A O   1 
HETATM 3201 O  O   . HOH J 4 .   ? -41.88124 11.23287 7.89366   1.000 40.55511 ? 627  HOH A O   1 
HETATM 3202 O  O   . HOH J 4 .   ? -37.05585 32.01364 -26.22599 1.000 32.03457 ? 628  HOH A O   1 
HETATM 3203 O  O   . HOH J 4 .   ? 1.87629   22.52714 -7.53976  1.000 19.74394 ? 629  HOH A O   1 
HETATM 3204 O  O   . HOH J 4 .   ? -18.62059 22.18796 2.62079   1.000 10.18172 ? 630  HOH A O   1 
HETATM 3205 O  O   . HOH J 4 .   ? -36.11064 12.06702 -8.80450  1.000 29.77360 ? 631  HOH A O   1 
HETATM 3206 O  O   . HOH J 4 .   ? -11.29482 23.08301 -10.45879 1.000 17.47306 ? 632  HOH A O   1 
HETATM 3207 O  O   . HOH J 4 .   ? -38.29637 31.52671 17.10843  1.000 19.81228 ? 633  HOH A O   1 
HETATM 3208 O  O   . HOH J 4 .   ? -35.71284 17.46495 16.04258  1.000 32.27396 ? 634  HOH A O   1 
HETATM 3209 O  O   . HOH J 4 .   ? -12.34791 27.14284 14.10489  1.000 26.39774 ? 635  HOH A O   1 
HETATM 3210 O  O   . HOH J 4 .   ? -35.79005 18.56330 -15.46484 1.000 19.23926 ? 636  HOH A O   1 
HETATM 3211 O  O   . HOH J 4 .   ? -35.10031 36.79430 5.73871   1.000 24.45017 ? 637  HOH A O   1 
HETATM 3212 O  O   . HOH J 4 .   ? -8.92263  22.13775 -25.79533 1.000 15.48963 ? 638  HOH A O   1 
HETATM 3213 O  O   . HOH J 4 .   ? -23.22244 15.73833 -21.72434 1.000 25.94165 ? 639  HOH A O   1 
HETATM 3214 O  O   . HOH J 4 .   ? 4.62160   49.00373 -9.09922  1.000 34.08954 ? 640  HOH A O   1 
HETATM 3215 O  O   . HOH J 4 .   ? 2.24467   40.44423 -1.58637  1.000 41.29199 ? 641  HOH A O   1 
HETATM 3216 O  O   . HOH J 4 .   ? -12.19922 33.47245 -9.21155  1.000 9.07799  ? 642  HOH A O   1 
HETATM 3217 O  O   . HOH J 4 .   ? 4.95867   42.85712 -6.65508  1.000 41.94475 ? 643  HOH A O   1 
HETATM 3218 O  O   . HOH J 4 .   ? 2.20490   55.11310 -7.55086  1.000 42.20367 ? 644  HOH A O   1 
HETATM 3219 O  O   . HOH J 4 .   ? -26.91345 7.95555  -5.27764  1.000 29.71029 ? 645  HOH A O   1 
HETATM 3220 O  O   . HOH J 4 .   ? -0.23844  53.97770 -10.38352 1.000 30.73284 ? 646  HOH A O   1 
HETATM 3221 O  O   . HOH J 4 .   ? -21.55324 19.16370 -22.47359 1.000 8.45414  ? 647  HOH A O   1 
HETATM 3222 O  O   . HOH J 4 .   ? -25.91884 8.58564  -1.50335  1.000 24.86657 ? 648  HOH A O   1 
HETATM 3223 O  O   . HOH J 4 .   ? -19.67112 45.73677 -6.42645  1.000 27.64906 ? 649  HOH A O   1 
HETATM 3224 O  O   . HOH J 4 .   ? -10.41255 3.80764  7.17565   1.000 43.73793 ? 650  HOH A O   1 
HETATM 3225 O  O   . HOH J 4 .   ? -37.29315 31.54227 -5.83347  1.000 11.96348 ? 651  HOH A O   1 
HETATM 3226 O  O   . HOH J 4 .   ? -12.72272 16.88981 9.04913   1.000 25.18511 ? 652  HOH A O   1 
HETATM 3227 O  O   . HOH J 4 .   ? -12.43043 40.25319 -8.54602  1.000 10.96148 ? 653  HOH A O   1 
HETATM 3228 O  O   . HOH J 4 .   ? -40.83464 22.99784 10.98715  1.000 16.97702 ? 654  HOH A O   1 
HETATM 3229 O  O   . HOH J 4 .   ? -7.36103  25.59983 3.94704   1.000 20.74786 ? 655  HOH A O   1 
HETATM 3230 O  O   . HOH J 4 .   ? -38.72239 30.84108 -17.42860 1.000 19.91723 ? 656  HOH A O   1 
HETATM 3231 O  O   . HOH J 4 .   ? -14.91101 32.22707 5.68437   1.000 28.90154 ? 657  HOH A O   1 
HETATM 3232 O  O   . HOH J 4 .   ? -24.89105 35.24614 -14.52746 1.000 8.42041  ? 658  HOH A O   1 
HETATM 3233 O  O   . HOH J 4 .   ? -45.21974 14.95533 2.90200   1.000 12.64879 ? 659  HOH A O   1 
HETATM 3234 O  O   . HOH J 4 .   ? -8.67494  27.57204 2.09046   1.000 17.74620 ? 660  HOH A O   1 
HETATM 3235 O  O   . HOH J 4 .   ? -14.43990 52.13933 -11.13246 1.000 29.72061 ? 661  HOH A O   1 
HETATM 3236 O  O   . HOH J 4 .   ? -29.85755 37.25331 -0.95345  1.000 33.44099 ? 662  HOH A O   1 
HETATM 3237 O  O   . HOH J 4 .   ? -33.88728 41.17808 -18.61694 1.000 26.15536 ? 663  HOH A O   1 
HETATM 3238 O  O   . HOH J 4 .   ? -24.40352 31.14413 -36.08331 1.000 39.91879 ? 664  HOH A O   1 
HETATM 3239 O  O   . HOH J 4 .   ? -30.40329 33.36373 -9.24008  1.000 7.87439  ? 665  HOH A O   1 
HETATM 3240 O  O   . HOH J 4 .   ? -23.44322 25.65552 -7.13392  1.000 25.07792 ? 666  HOH A O   1 
HETATM 3241 O  O   . HOH J 4 .   ? -33.02654 15.86338 22.45272  1.000 40.13052 ? 667  HOH A O   1 
HETATM 3242 O  O   . HOH J 4 .   ? -17.14542 15.38184 -26.01287 1.000 9.36901  ? 668  HOH A O   1 
HETATM 3243 O  O   . HOH J 4 .   ? -2.29410  17.20116 0.83498   1.000 28.16382 ? 669  HOH A O   1 
HETATM 3244 O  O   . HOH J 4 .   ? -9.17647  37.42954 -7.43127  1.000 15.32501 ? 670  HOH A O   1 
HETATM 3245 O  O   . HOH J 4 .   ? -27.24316 20.29134 22.84020  1.000 29.01671 ? 671  HOH A O   1 
HETATM 3246 O  O   . HOH J 4 .   ? -32.08282 18.10257 -13.54236 1.000 12.18886 ? 672  HOH A O   1 
HETATM 3247 O  O   . HOH J 4 .   ? -29.50723 22.33158 -23.26942 1.000 10.19270 ? 673  HOH A O   1 
HETATM 3248 O  O   . HOH J 4 .   ? -0.12470  18.80954 -1.91737  1.000 18.73429 ? 674  HOH A O   1 
HETATM 3249 O  O   . HOH J 4 .   ? -7.61916  22.63491 -23.54093 1.000 10.57801 ? 675  HOH A O   1 
HETATM 3250 O  O   . HOH J 4 .   ? -18.81688 22.37070 -30.78307 1.000 13.49398 ? 676  HOH A O   1 
HETATM 3251 O  O   . HOH J 4 .   ? 0.48185   39.89085 -17.82201 1.000 22.38752 ? 677  HOH A O   1 
HETATM 3252 O  O   . HOH J 4 .   ? -37.85936 35.79470 -1.46583  1.000 23.91371 ? 678  HOH A O   1 
HETATM 3253 O  O   . HOH J 4 .   ? -40.63011 17.50207 -8.88332  1.000 16.39060 ? 679  HOH A O   1 
HETATM 3254 O  O   . HOH J 4 .   ? -27.72566 35.66566 5.54021   1.000 28.55526 ? 680  HOH A O   1 
HETATM 3255 O  O   . HOH J 4 .   ? -18.50333 32.59484 1.71959   1.000 31.19415 ? 681  HOH A O   1 
HETATM 3256 O  O   . HOH J 4 .   ? -31.03937 26.42681 5.13779   1.000 16.76805 ? 682  HOH A O   1 
HETATM 3257 O  O   . HOH J 4 .   ? -4.87683  55.33005 -13.56840 1.000 26.73244 ? 683  HOH A O   1 
HETATM 3258 O  O   . HOH J 4 .   ? -37.68416 37.01789 8.40500   1.000 29.30143 ? 684  HOH A O   1 
HETATM 3259 O  O   . HOH J 4 .   ? -40.77540 24.03232 -19.41812 1.000 18.41733 ? 685  HOH A O   1 
HETATM 3260 O  O   . HOH J 4 .   ? -24.61119 37.26355 -33.53190 1.000 30.57247 ? 686  HOH A O   1 
HETATM 3261 O  O   . HOH J 4 .   ? -40.423   37.324   -6.452    1.000 38.47583 ? 687  HOH A O   1 
HETATM 3262 O  O   . HOH J 4 .   ? -3.37638  41.18230 -5.42222  1.000 19.76122 ? 688  HOH A O   1 
HETATM 3263 O  O   . HOH J 4 .   ? -44.69251 13.09061 -4.91947  1.000 31.69018 ? 689  HOH A O   1 
HETATM 3264 O  O   . HOH J 4 .   ? -26.92549 21.98600 -32.49038 1.000 28.34590 ? 690  HOH A O   1 
HETATM 3265 O  O   . HOH J 4 .   ? -18.23415 11.26848 -12.80097 1.000 18.63382 ? 691  HOH A O   1 
HETATM 3266 O  O   . HOH J 4 .   ? -12.39922 19.20984 10.36465  1.000 28.25115 ? 692  HOH A O   1 
HETATM 3267 O  O   . HOH J 4 .   ? -41.67889 25.88175 7.22120   1.000 12.72081 ? 693  HOH A O   1 
HETATM 3268 O  O   . HOH J 4 .   ? -18.62454 44.92143 -2.80486  1.000 29.76249 ? 694  HOH A O   1 
HETATM 3269 O  O   . HOH J 4 .   ? -28.89205 6.84988  -0.11729  1.000 26.60951 ? 695  HOH A O   1 
HETATM 3270 O  O   . HOH J 4 .   ? -42.61916 13.69336 7.22597   1.000 38.40385 ? 696  HOH A O   1 
HETATM 3271 O  O   . HOH J 4 .   ? -23.08432 14.52364 -16.68367 1.000 26.09294 ? 697  HOH A O   1 
HETATM 3272 O  O   . HOH J 4 .   ? -24.52918 24.21118 -35.41517 1.000 35.18396 ? 698  HOH A O   1 
HETATM 3273 O  O   . HOH J 4 .   ? -41.74728 21.80212 -10.46315 1.000 32.40599 ? 699  HOH A O   1 
HETATM 3274 O  O   . HOH J 4 .   ? -29.84827 25.25471 -23.34418 1.000 8.85446  ? 700  HOH A O   1 
HETATM 3275 O  O   . HOH J 4 .   ? -16.45341 49.29737 -13.72251 1.000 27.36500 ? 701  HOH A O   1 
HETATM 3276 O  O   . HOH J 4 .   ? -9.08365  35.18955 -22.26319 1.000 7.56110  ? 702  HOH A O   1 
HETATM 3277 O  O   . HOH J 4 .   ? -9.69946  21.07204 -23.67532 1.000 12.66413 ? 703  HOH A O   1 
HETATM 3278 O  O   . HOH J 4 .   ? -16.33845 37.83041 -1.60737  1.000 20.47657 ? 704  HOH A O   1 
HETATM 3279 O  O   . HOH J 4 .   ? -4.82765  12.40199 -4.94245  1.000 17.47700 ? 705  HOH A O   1 
HETATM 3280 O  O   . HOH J 4 .   ? -41.47804 13.41223 -1.70910  1.000 19.62762 ? 706  HOH A O   1 
HETATM 3281 O  O   . HOH J 4 .   ? 1.493     15.240   -3.918    1.000 33.09685 ? 707  HOH A O   1 
HETATM 3282 O  O   . HOH J 4 .   ? -36.59042 27.71382 22.13822  1.000 36.12080 ? 708  HOH A O   1 
HETATM 3283 O  O   . HOH J 4 .   ? -40.13762 38.39504 3.58220   1.000 36.91872 ? 709  HOH A O   1 
HETATM 3284 O  O   . HOH J 4 .   ? -30.37851 34.49019 14.00212  1.000 26.67051 ? 710  HOH A O   1 
HETATM 3285 O  O   . HOH J 4 .   ? -43.09753 11.66471 -8.61344  1.000 44.24863 ? 711  HOH A O   1 
HETATM 3286 O  O   . HOH J 4 .   ? -14.37412 51.58808 -0.70825  1.000 28.78976 ? 712  HOH A O   1 
HETATM 3287 O  O   . HOH J 4 .   ? -28.60202 32.21259 17.38453  1.000 26.05914 ? 713  HOH A O   1 
HETATM 3288 O  O   . HOH J 4 .   ? -23.37154 24.90984 -10.06682 1.000 9.09830  ? 714  HOH A O   1 
HETATM 3289 O  O   . HOH J 4 .   ? -1.17270  31.53171 -17.74691 1.000 13.77874 ? 715  HOH A O   1 
HETATM 3290 O  O   . HOH J 4 .   ? -20.04119 10.14001 -22.45028 1.000 17.32278 ? 716  HOH A O   1 
HETATM 3291 O  O   . HOH J 4 .   ? -2.61358  33.42046 -9.41896  1.000 18.60352 ? 717  HOH A O   1 
HETATM 3292 O  O   . HOH J 4 .   ? -19.61052 1.80049  7.08329   1.000 34.38883 ? 718  HOH A O   1 
HETATM 3293 O  O   . HOH J 4 .   ? -21.67373 35.72052 -11.15939 1.000 9.52275  ? 719  HOH A O   1 
HETATM 3294 O  O   . HOH J 4 .   ? -36.22917 6.42531  -4.45067  1.000 37.08049 ? 720  HOH A O   1 
HETATM 3295 O  O   . HOH J 4 .   ? -16.42135 6.34164  3.65749   1.000 31.46504 ? 721  HOH A O   1 
HETATM 3296 O  O   . HOH J 4 .   ? -37.54979 35.23887 -15.56137 1.000 25.64037 ? 722  HOH A O   1 
HETATM 3297 O  O   . HOH J 4 .   ? -41.20479 28.58352 15.10038  1.000 25.41859 ? 723  HOH A O   1 
HETATM 3298 O  O   . HOH J 4 .   ? -3.74328  43.71630 -2.41973  1.000 21.12051 ? 724  HOH A O   1 
HETATM 3299 O  O   . HOH J 4 .   ? -4.61544  41.50869 -7.76067  1.000 13.16082 ? 725  HOH A O   1 
HETATM 3300 O  O   . HOH J 4 .   ? -7.69285  10.17932 -19.34022 1.000 26.80117 ? 726  HOH A O   1 
HETATM 3301 O  O   . HOH J 4 .   ? -2.29912  22.98208 0.16964   1.000 27.93583 ? 727  HOH A O   1 
HETATM 3302 O  O   . HOH J 4 .   ? -32.45279 26.86269 -0.02544  1.000 8.62286  ? 728  HOH A O   1 
HETATM 3303 O  O   . HOH J 4 .   ? -40.52908 25.39776 9.68353   1.000 14.93123 ? 729  HOH A O   1 
HETATM 3304 O  O   . HOH J 4 .   ? -12.48691 27.61823 -5.00539  1.000 9.61860  ? 730  HOH A O   1 
HETATM 3305 O  O   . HOH J 4 .   ? -33.88470 41.26997 -24.92125 1.000 28.34042 ? 731  HOH A O   1 
HETATM 3306 O  O   . HOH J 4 .   ? -0.80652  14.01125 -18.15687 1.000 39.35466 ? 732  HOH A O   1 
HETATM 3307 O  O   . HOH J 4 .   ? -36.51446 25.94753 -26.71715 1.000 35.68843 ? 733  HOH A O   1 
HETATM 3308 O  O   . HOH J 4 .   ? -1.09178  43.85199 -22.83074 1.000 19.66359 ? 734  HOH A O   1 
HETATM 3309 O  O   . HOH J 4 .   ? -12.14426 52.09734 1.24734   1.000 37.94712 ? 735  HOH A O   1 
HETATM 3310 O  O   . HOH J 4 .   ? 0.07150   14.69927 -13.58529 1.000 36.34149 ? 736  HOH A O   1 
HETATM 3311 O  O   . HOH J 4 .   ? -25.84549 37.01725 3.75006   1.000 32.65732 ? 737  HOH A O   1 
HETATM 3312 O  O   . HOH J 4 .   ? -8.65127  9.85886  -14.89660 1.000 27.29286 ? 738  HOH A O   1 
HETATM 3313 O  O   . HOH J 4 .   ? -41.14798 25.41746 -13.23933 1.000 24.47655 ? 739  HOH A O   1 
HETATM 3314 O  O   . HOH J 4 .   ? -12.80784 24.57423 -5.36847  1.000 11.02177 ? 740  HOH A O   1 
HETATM 3315 O  O   . HOH J 4 .   ? -29.83440 40.39840 -19.07993 1.000 31.33851 ? 741  HOH A O   1 
HETATM 3316 O  O   . HOH J 4 .   ? -31.52659 16.34848 -15.48293 1.000 19.29561 ? 742  HOH A O   1 
HETATM 3317 O  O   . HOH J 4 .   ? -23.89220 37.65311 -18.77915 1.000 11.48768 ? 743  HOH A O   1 
HETATM 3318 O  O   . HOH J 4 .   ? -23.31402 35.88010 -0.00651  1.000 25.12831 ? 744  HOH A O   1 
HETATM 3319 O  O   . HOH J 4 .   ? -43.20286 15.79637 -11.59844 1.000 41.92001 ? 745  HOH A O   1 
HETATM 3320 O  O   . HOH J 4 .   ? -44.37371 33.43871 -12.36084 1.000 33.33934 ? 746  HOH A O   1 
HETATM 3321 O  O   . HOH J 4 .   ? -15.09293 28.77341 11.86012  1.000 19.00682 ? 747  HOH A O   1 
HETATM 3322 O  O   . HOH J 4 .   ? -17.23790 9.41907  -11.56099 1.000 32.38875 ? 748  HOH A O   1 
HETATM 3323 O  O   . HOH J 4 .   ? -17.49218 11.09464 -19.24281 1.000 15.03290 ? 749  HOH A O   1 
HETATM 3324 O  O   . HOH J 4 .   ? -20.71423 21.34920 -32.39100 1.000 16.24284 ? 750  HOH A O   1 
HETATM 3325 O  O   . HOH J 4 .   ? -14.78500 7.65850  -8.54236  1.000 34.53313 ? 751  HOH A O   1 
HETATM 3326 O  O   . HOH J 4 .   ? -32.32919 24.78217 -26.50952 1.000 28.77315 ? 752  HOH A O   1 
HETATM 3327 O  O   . HOH J 4 .   ? -10.91364 36.88987 -29.23280 1.000 10.71760 ? 753  HOH A O   1 
HETATM 3328 O  O   . HOH J 4 .   ? -24.20364 26.85075 -36.07346 1.000 37.12483 ? 754  HOH A O   1 
HETATM 3329 O  O   . HOH J 4 .   ? 4.00665   44.87599 -0.03749  1.000 33.66412 ? 755  HOH A O   1 
HETATM 3330 O  O   . HOH J 4 .   ? -21.16078 42.17482 -12.76659 1.000 12.31633 ? 756  HOH A O   1 
HETATM 3331 O  O   . HOH J 4 .   ? -4.056    57.161   3.023     1.000 44.84948 ? 757  HOH A O   1 
HETATM 3332 O  O   . HOH J 4 .   ? -35.84739 7.81572  -0.32233  1.000 32.23662 ? 758  HOH A O   1 
HETATM 3333 O  O   . HOH J 4 .   ? -41.79405 16.83506 -13.70663 1.000 38.18179 ? 759  HOH A O   1 
HETATM 3334 O  O   . HOH J 4 .   ? -41.53582 23.18100 18.54477  1.000 43.43076 ? 760  HOH A O   1 
HETATM 3335 O  O   . HOH J 4 .   ? -43.82919 20.19861 5.39792   1.000 12.21344 ? 761  HOH A O   1 
HETATM 3336 O  O   . HOH J 4 .   ? -24.32885 36.79819 -6.86010  1.000 18.35988 ? 762  HOH A O   1 
HETATM 3337 O  O   . HOH J 4 .   ? -2.40545  37.02241 -4.62987  1.000 25.62150 ? 763  HOH A O   1 
HETATM 3338 O  O   . HOH J 4 .   ? -21.48534 24.86859 20.57255  1.000 33.80478 ? 764  HOH A O   1 
HETATM 3339 O  O   . HOH J 4 .   ? 2.28028   38.28413 -26.11467 1.000 43.51570 ? 765  HOH A O   1 
HETATM 3340 O  O   . HOH J 4 .   ? -1.80766  39.21497 -0.75415  1.000 41.28351 ? 766  HOH A O   1 
HETATM 3341 O  O   . HOH J 4 .   ? -1.37145  41.33240 -13.58647 1.000 37.94147 ? 767  HOH A O   1 
HETATM 3342 O  O   . HOH J 4 .   ? -5.99973  39.54451 -25.66284 1.000 30.00997 ? 768  HOH A O   1 
HETATM 3343 O  O   . HOH J 4 .   ? -40.27333 33.58242 10.75416  1.000 18.63083 ? 769  HOH A O   1 
HETATM 3344 O  O   . HOH J 4 .   ? 2.61498   36.97475 -19.19376 1.000 28.33420 ? 770  HOH A O   1 
HETATM 3345 O  O   . HOH J 4 .   ? -14.11417 43.85260 1.89155   1.000 44.71200 ? 771  HOH A O   1 
HETATM 3346 O  O   . HOH J 4 .   ? -17.07679 30.94144 -19.66050 1.000 5.32052  ? 772  HOH A O   1 
HETATM 3347 O  O   . HOH J 4 .   ? -26.21134 20.43776 -27.41829 1.000 12.24261 ? 773  HOH A O   1 
HETATM 3348 O  O   . HOH J 4 .   ? -1.36041  27.70620 -13.32715 1.000 24.90133 ? 774  HOH A O   1 
HETATM 3349 O  O   . HOH J 4 .   ? -20.62591 18.13321 16.78586  1.000 24.66289 ? 775  HOH A O   1 
HETATM 3350 O  O   . HOH J 4 .   ? -1.46407  18.37992 -13.68903 1.000 30.10621 ? 776  HOH A O   1 
HETATM 3351 O  O   . HOH J 4 .   ? -8.67905  7.11634  -14.95624 1.000 31.26654 ? 777  HOH A O   1 
HETATM 3352 O  O   . HOH J 4 .   ? -10.99749 21.46556 -8.08254  1.000 20.57309 ? 778  HOH A O   1 
HETATM 3353 O  O   . HOH J 4 .   ? -20.90248 22.70097 18.41566  1.000 29.53946 ? 779  HOH A O   1 
HETATM 3354 O  O   . HOH J 4 .   ? -38.28932 37.10092 -13.24617 1.000 30.56226 ? 780  HOH A O   1 
HETATM 3355 O  O   . HOH J 4 .   ? -11.15841 39.56177 -34.58439 1.000 19.06709 ? 781  HOH A O   1 
HETATM 3356 O  O   . HOH J 4 .   ? -9.21657  27.37720 -31.42154 1.000 22.20763 ? 782  HOH A O   1 
HETATM 3357 O  O   . HOH J 4 .   ? -23.54332 28.84816 20.65809  1.000 36.56167 ? 783  HOH A O   1 
HETATM 3358 O  O   . HOH J 4 .   ? -1.48875  25.42825 -5.77519  1.000 17.88509 ? 784  HOH A O   1 
HETATM 3359 O  O   . HOH J 4 .   ? -6.02498  58.50840 -3.83462  1.000 29.79437 ? 785  HOH A O   1 
HETATM 3360 O  O   . HOH J 4 .   ? -9.80701  9.55326  7.44976   1.000 33.48043 ? 786  HOH A O   1 
HETATM 3361 O  O   . HOH J 4 .   ? -22.07142 39.97854 -30.18697 1.000 31.62374 ? 787  HOH A O   1 
HETATM 3362 O  O   . HOH J 4 .   ? -11.45862 34.84153 -6.99344  1.000 11.65755 ? 788  HOH A O   1 
HETATM 3363 O  O   . HOH J 4 .   ? -23.32486 34.43980 -6.20122  1.000 28.91031 ? 789  HOH A O   1 
HETATM 3364 O  O   . HOH J 4 .   ? -33.04587 37.25586 7.91208   1.000 19.04818 ? 790  HOH A O   1 
HETATM 3365 O  O   . HOH J 4 .   ? -4.31073  33.64060 -3.44643  1.000 29.88179 ? 791  HOH A O   1 
HETATM 3366 O  O   . HOH J 4 .   ? -3.16606  37.23327 -12.20661 1.000 17.05963 ? 792  HOH A O   1 
HETATM 3367 O  O   . HOH J 4 .   ? -39.47514 33.80367 -5.72499  1.000 25.68399 ? 793  HOH A O   1 
HETATM 3368 O  O   . HOH J 4 .   ? -13.43434 40.22037 -24.50788 1.000 14.15659 ? 794  HOH A O   1 
HETATM 3369 O  O   . HOH J 4 .   ? -7.71740  21.32526 -32.69816 1.000 17.39285 ? 795  HOH A O   1 
HETATM 3370 O  O   . HOH J 4 .   ? 0.91103   22.19524 -11.95626 1.000 18.66859 ? 796  HOH A O   1 
HETATM 3371 O  O   . HOH J 4 .   ? -12.18965 55.52734 -1.22404  1.000 33.80838 ? 797  HOH A O   1 
HETATM 3372 O  O   . HOH J 4 .   ? 0.91797   56.90723 -3.51092  1.000 33.25429 ? 798  HOH A O   1 
HETATM 3373 O  O   . HOH J 4 .   ? -23.89116 17.76101 -31.31955 1.000 29.47925 ? 799  HOH A O   1 
HETATM 3374 O  O   . HOH J 4 .   ? -26.98337 25.28954 -31.31707 1.000 21.30096 ? 800  HOH A O   1 
HETATM 3375 O  O   . HOH J 4 .   ? -21.93188 33.23343 19.28107  1.000 40.78030 ? 801  HOH A O   1 
HETATM 3376 O  O   . HOH J 4 .   ? -27.99732 21.16249 -25.05429 1.000 9.98684  ? 802  HOH A O   1 
HETATM 3377 O  O   . HOH J 4 .   ? -3.30654  12.27466 -7.73353  1.000 27.67489 ? 803  HOH A O   1 
HETATM 3378 O  O   . HOH J 4 .   ? -4.64437  27.40561 4.15990   1.000 31.54831 ? 804  HOH A O   1 
HETATM 3379 O  O   . HOH J 4 .   ? -13.97352 20.53860 13.68249  1.000 27.21570 ? 805  HOH A O   1 
HETATM 3380 O  O   . HOH J 4 .   ? -13.13945 29.75280 7.73730   1.000 20.72235 ? 806  HOH A O   1 
HETATM 3381 O  O   . HOH J 4 .   ? -12.32515 10.26623 8.56014   1.000 26.87691 ? 807  HOH A O   1 
HETATM 3382 O  O   . HOH J 4 .   ? 0.57000   49.29375 -10.28921 1.000 18.51136 ? 808  HOH A O   1 
HETATM 3383 O  O   . HOH J 4 .   ? -33.84852 38.35958 -11.53434 1.000 19.43440 ? 809  HOH A O   1 
HETATM 3384 O  O   . HOH J 4 .   ? -7.54741  17.26115 -24.19651 1.000 29.48721 ? 810  HOH A O   1 
HETATM 3385 O  O   . HOH J 4 .   ? -2.81351  24.71476 -26.84855 1.000 35.71925 ? 811  HOH A O   1 
HETATM 3386 O  O   . HOH J 4 .   ? -35.23534 36.34119 9.56604   1.000 20.08886 ? 812  HOH A O   1 
HETATM 3387 O  O   . HOH J 4 .   ? -16.35193 47.93061 -17.45183 1.000 19.41120 ? 813  HOH A O   1 
HETATM 3388 O  O   . HOH J 4 .   ? -8.68942  18.67321 10.29021  1.000 42.15952 ? 814  HOH A O   1 
HETATM 3389 O  O   . HOH J 4 .   ? -35.74246 18.49017 -20.33542 1.000 29.99128 ? 815  HOH A O   1 
HETATM 3390 O  O   . HOH J 4 .   ? -37.02045 28.70600 -23.76145 1.000 13.43356 ? 816  HOH A O   1 
HETATM 3391 O  O   . HOH J 4 .   ? -23.00906 43.63661 -13.95977 1.000 30.31577 ? 817  HOH A O   1 
HETATM 3392 O  O   . HOH J 4 .   ? -20.50459 27.63154 -35.25127 1.000 24.23527 ? 818  HOH A O   1 
HETATM 3393 O  O   . HOH J 4 .   ? -24.74039 18.71371 19.52712  1.000 32.00338 ? 819  HOH A O   1 
HETATM 3394 O  O   . HOH J 4 .   ? -25.14914 21.16586 20.26601  1.000 33.42484 ? 820  HOH A O   1 
HETATM 3395 O  O   . HOH J 4 .   ? -20.06547 31.48513 -4.83844  1.000 20.80168 ? 821  HOH A O   1 
HETATM 3396 O  O   . HOH J 4 .   ? -2.53664  35.60962 -2.18240  1.000 39.15371 ? 822  HOH A O   1 
HETATM 3397 O  O   . HOH J 4 .   ? -33.11082 14.23472 8.49144   1.000 27.67803 ? 823  HOH A O   1 
HETATM 3398 O  O   . HOH J 4 .   ? -42.84926 31.30690 -11.89442 1.000 21.00251 ? 824  HOH A O   1 
HETATM 3399 O  O   . HOH J 4 .   ? 0.00000   43.50266 0.00000   0.50  32.68600 ? 825  HOH A O   1 
HETATM 3400 O  O   . HOH J 4 .   ? -27.98593 29.08092 -31.86086 1.000 31.35783 ? 826  HOH A O   1 
HETATM 3401 O  O   . HOH J 4 .   ? -11.85055 38.07452 -6.83829  1.000 14.36096 ? 827  HOH A O   1 
HETATM 3402 O  O   . HOH J 4 .   ? -25.00821 37.43704 -3.51345  1.000 37.91506 ? 828  HOH A O   1 
HETATM 3403 O  O   . HOH J 4 .   ? -4.72792  60.94081 -13.02818 1.000 48.53595 ? 829  HOH A O   1 
HETATM 3404 O  O   . HOH J 4 .   ? -17.94907 15.75478 -28.49500 1.000 23.32791 ? 830  HOH A O   1 
HETATM 3405 O  O   . HOH J 4 .   ? -18.19562 31.64012 9.45043   1.000 19.04973 ? 831  HOH A O   1 
HETATM 3406 O  O   . HOH J 4 .   ? -23.59782 7.68211  0.06975   1.000 35.20041 ? 832  HOH A O   1 
HETATM 3407 O  O   . HOH J 4 .   ? -1.70195  16.49015 -16.33736 1.000 26.86626 ? 833  HOH A O   1 
HETATM 3408 O  O   . HOH J 4 .   ? -9.62420  53.79382 1.41451   1.000 28.90143 ? 834  HOH A O   1 
HETATM 3409 O  O   . HOH J 4 .   ? -44.073   26.460   11.580    1.000 29.56853 ? 835  HOH A O   1 
HETATM 3410 O  O   . HOH J 4 .   ? -22.36902 32.55052 21.55930  1.000 39.72326 ? 836  HOH A O   1 
HETATM 3411 O  O   . HOH J 4 .   ? -16.06938 32.70817 3.03987   1.000 34.93424 ? 837  HOH A O   1 
HETATM 3412 O  O   . HOH J 4 .   ? -29.53912 39.34634 -6.57762  1.000 34.23474 ? 838  HOH A O   1 
HETATM 3413 O  O   . HOH J 4 .   ? -41.46718 24.14328 -10.94411 1.000 29.62999 ? 839  HOH A O   1 
HETATM 3414 O  O   . HOH J 4 .   ? -21.22268 24.89390 -35.19982 1.000 35.38211 ? 840  HOH A O   1 
HETATM 3415 O  O   . HOH J 4 .   ? -41.75524 37.64955 10.56737  1.000 36.83432 ? 841  HOH A O   1 
HETATM 3416 O  O   . HOH J 4 .   ? -5.33290  28.19639 6.44678   1.000 35.94495 ? 842  HOH A O   1 
HETATM 3417 O  O   . HOH J 4 .   ? -24.85102 22.76116 21.90549  1.000 38.35462 ? 843  HOH A O   1 
HETATM 3418 O  O   . HOH J 4 .   ? -22.52179 34.73602 -3.87201  1.000 30.31064 ? 844  HOH A O   1 
HETATM 3419 O  O   . HOH J 4 .   ? -15.44539 48.44888 -19.95078 1.000 24.59799 ? 845  HOH A O   1 
HETATM 3420 O  O   . HOH J 4 .   ? -22.20755 32.51899 -4.30895  1.000 26.33552 ? 846  HOH A O   1 
HETATM 3421 O  O   . HOH J 4 .   ? -42.41981 17.99293 -11.80412 1.000 34.15878 ? 847  HOH A O   1 
HETATM 3422 O  O   . HOH J 4 .   ? -22.26074 41.82526 -10.76708 1.000 26.78450 ? 848  HOH A O   1 
HETATM 3423 O  O   . HOH J 4 .   ? -20.85682 41.87400 -8.44335  1.000 21.44235 ? 849  HOH A O   1 
HETATM 3424 O  O   . HOH J 4 .   ? -18.72193 29.39093 19.85414  1.000 35.09626 ? 850  HOH A O   1 
HETATM 3425 O  O   . HOH J 4 .   ? -41.80616 21.41611 -13.80768 1.000 32.40388 ? 851  HOH A O   1 
HETATM 3426 O  O   . HOH J 4 .   ? -3.66191  46.44348 -24.25082 1.000 24.55700 ? 852  HOH A O   1 
HETATM 3427 O  O   . HOH J 4 .   ? -35.18308 36.90735 12.35389  1.000 24.69055 ? 853  HOH A O   1 
HETATM 3428 O  O   . HOH J 4 .   ? -42.43445 29.82871 -14.08106 1.000 26.10473 ? 854  HOH A O   1 
HETATM 3429 O  O   . HOH J 4 .   ? -2.22775  26.59370 -1.89921  1.000 31.81917 ? 855  HOH A O   1 
HETATM 3430 O  O   . HOH J 4 .   ? -13.48481 15.44334 -27.21492 1.000 26.56839 ? 856  HOH A O   1 
HETATM 3431 O  O   . HOH J 4 .   ? -28.30285 17.65844 -20.81483 1.000 28.96600 ? 857  HOH A O   1 
HETATM 3432 O  O   . HOH J 4 .   ? -11.14733 29.72994 9.10258   1.000 24.62886 ? 858  HOH A O   1 
HETATM 3433 O  O   . HOH J 4 .   ? -25.42023 42.94594 -15.85151 1.000 30.13049 ? 859  HOH A O   1 
HETATM 3434 O  O   . HOH J 4 .   ? -30.75194 23.40257 -26.17199 1.000 27.12786 ? 860  HOH A O   1 
HETATM 3435 O  O   . HOH J 4 .   ? -14.74420 33.27240 -1.28621  1.000 25.89966 ? 861  HOH A O   1 
HETATM 3436 O  O   . HOH J 4 .   ? -20.65528 29.73732 -6.06288  1.000 32.48847 ? 862  HOH A O   1 
HETATM 3437 O  O   . HOH J 4 .   ? -24.88943 35.77298 7.18859   1.000 37.07488 ? 863  HOH A O   1 
HETATM 3438 O  O   . HOH J 4 .   ? -10.34776 39.23273 -28.47728 1.000 15.40646 ? 864  HOH A O   1 
HETATM 3439 O  O   . HOH J 4 .   ? -13.40758 32.36010 -3.02570  1.000 22.42025 ? 865  HOH A O   1 
HETATM 3440 O  O   . HOH J 4 .   ? -21.42308 9.06648  -27.72240 1.000 28.41599 ? 866  HOH A O   1 
HETATM 3441 O  O   . HOH J 4 .   ? -0.40902  32.53318 -24.00803 1.000 30.23587 ? 867  HOH A O   1 
HETATM 3442 O  O   . HOH J 4 .   ? -20.157   45.475   -23.892   1.000 25.10198 ? 868  HOH A O   1 
HETATM 3443 O  O   . HOH J 4 .   ? -5.93861  9.98288  -4.93588  1.000 33.73710 ? 869  HOH A O   1 
HETATM 3444 O  O   . HOH J 4 .   ? -41.42428 37.27057 1.76038   1.000 36.28942 ? 870  HOH A O   1 
HETATM 3445 O  O   . HOH J 4 .   ? -10.28015 16.32049 10.01844  1.000 32.98681 ? 871  HOH A O   1 
HETATM 3446 O  O   . HOH J 4 .   ? -20.12913 12.96650 -17.55511 1.000 12.13880 ? 872  HOH A O   1 
HETATM 3447 O  O   . HOH J 4 .   ? -25.50018 17.07679 -24.75792 1.000 28.19666 ? 873  HOH A O   1 
HETATM 3448 O  O   . HOH J 4 .   ? -13.30102 15.56464 -31.44166 1.000 23.76059 ? 874  HOH A O   1 
HETATM 3449 O  O   . HOH J 4 .   ? -28.94023 27.73217 -29.98728 1.000 27.97567 ? 875  HOH A O   1 
HETATM 3450 O  O   . HOH J 4 .   ? -27.15548 18.48298 -24.32177 1.000 28.43063 ? 876  HOH A O   1 
HETATM 3451 O  O   . HOH J 4 .   ? -36.92162 31.19808 -24.14356 1.000 25.60183 ? 877  HOH A O   1 
HETATM 3452 O  O   . HOH J 4 .   ? -18.54506 11.23164 -15.40342 1.000 16.63204 ? 878  HOH A O   1 
HETATM 3453 O  O   . HOH J 4 .   ? -25.65679 29.90076 10.00898  1.000 28.75497 ? 879  HOH A O   1 
HETATM 3454 O  O   . HOH J 4 .   ? -20.18984 34.21755 2.56033   1.000 31.83153 ? 880  HOH A O   1 
HETATM 3455 O  O   . HOH J 4 .   ? -34.77500 12.85543 7.32929   1.000 26.85001 ? 881  HOH A O   1 
HETATM 3456 O  O   . HOH J 4 .   ? -34.16535 14.40914 -11.29034 1.000 27.37624 ? 882  HOH A O   1 
HETATM 3457 O  O   . HOH J 4 .   ? -15.768   45.828   -24.064   1.000 32.01834 ? 883  HOH A O   1 
HETATM 3458 O  O   . HOH J 4 .   ? -34.52269 14.91562 -13.41180 1.000 27.58381 ? 884  HOH A O   1 
HETATM 3459 O  O   . HOH J 4 .   ? -1.65462  35.12524 -11.65380 1.000 36.91307 ? 885  HOH A O   1 
HETATM 3460 O  O   . HOH J 4 .   ? -1.313    24.522   5.577     1.000 27.03837 ? 886  HOH A O   1 
HETATM 3461 O  O   . HOH J 4 .   ? -38.28358 20.48164 18.49871  1.000 35.83401 ? 887  HOH A O   1 
HETATM 3462 O  O   . HOH J 4 .   ? -16.79079 32.14049 -1.20043  1.000 31.47923 ? 888  HOH A O   1 
HETATM 3463 O  O   . HOH J 4 .   ? -3.78029  17.60319 -17.91641 1.000 16.83387 ? 889  HOH A O   1 
HETATM 3464 O  O   . HOH J 4 .   ? -7.24962  13.55332 1.60531   1.000 32.25508 ? 890  HOH A O   1 
HETATM 3465 O  O   . HOH J 4 .   ? 1.06277   30.90722 -19.75376 1.000 32.40949 ? 891  HOH A O   1 
HETATM 3466 O  O   . HOH J 4 .   ? -27.67966 19.45702 -29.32423 1.000 29.72189 ? 892  HOH A O   1 
HETATM 3467 O  O   . HOH J 4 .   ? -40.89194 21.90113 -20.93806 1.000 24.34621 ? 893  HOH A O   1 
HETATM 3468 O  O   . HOH J 4 .   ? -34.84309 27.98672 24.98503  1.000 40.65498 ? 894  HOH A O   1 
HETATM 3469 O  O   . HOH J 4 .   ? -31.95953 36.79747 -4.90292  1.000 25.78754 ? 895  HOH A O   1 
HETATM 3470 O  O   . HOH J 4 .   ? -3.59474  31.47901 -1.65685  1.000 39.99831 ? 896  HOH A O   1 
HETATM 3471 O  O   . HOH J 4 .   ? -1.78423  39.15391 -4.96670  1.000 27.68023 ? 897  HOH A O   1 
HETATM 3472 O  O   . HOH J 4 .   ? -14.54711 22.40992 15.90717  1.000 42.14386 ? 898  HOH A O   1 
HETATM 3473 O  O   . HOH J 4 .   ? -20.26857 20.55325 18.55125  1.000 37.97923 ? 899  HOH A O   1 
HETATM 3474 O  O   . HOH J 4 .   ? -2.51528  39.30822 -10.72015 1.000 28.27987 ? 900  HOH A O   1 
HETATM 3475 O  O   . HOH J 4 .   ? -9.01354  32.63338 -2.03249  1.000 36.63495 ? 901  HOH A O   1 
HETATM 3476 O  O   . HOH J 4 .   ? -3.22156  42.27489 -12.41991 1.000 26.93464 ? 902  HOH A O   1 
HETATM 3477 O  O   . HOH J 4 .   ? -3.606    18.243   6.572     1.000 35.15750 ? 903  HOH A O   1 
HETATM 3478 O  O   . HOH J 4 .   ? -19.94437 8.59795  -8.91470  1.000 30.79682 ? 904  HOH A O   1 
HETATM 3479 O  O   . HOH J 4 .   ? -1.40348  36.40503 -7.44269  1.000 37.97269 ? 905  HOH A O   1 
HETATM 3480 O  O   . HOH J 4 .   ? -10.36741 6.43062  -8.06497  1.000 32.12274 ? 906  HOH A O   1 
HETATM 3481 O  O   . HOH J 4 .   ? -20.90645 10.31398 -12.80755 1.000 35.79287 ? 907  HOH A O   1 
HETATM 3482 O  O   . HOH J 4 .   ? -24.49105 18.52942 -26.34082 1.000 20.91757 ? 908  HOH A O   1 
HETATM 3483 O  O   . HOH J 4 .   ? -2.98431  24.97327 -3.78414  1.000 30.84670 ? 909  HOH A O   1 
HETATM 3484 O  O   . HOH J 4 .   ? -37.87011 17.98271 17.70781  1.000 38.44254 ? 910  HOH A O   1 
HETATM 3485 O  O   . HOH J 4 .   ? -28.49790 22.34151 -27.62896 1.000 12.30249 ? 911  HOH A O   1 
HETATM 3486 O  O   . HOH J 4 .   ? -34.91248 36.01166 -4.78854  1.000 30.51516 ? 912  HOH A O   1 
HETATM 3487 O  O   . HOH J 4 .   ? 0.66848   18.87277 -13.48110 1.000 34.30922 ? 913  HOH A O   1 
HETATM 3488 O  O   . HOH J 4 .   ? -18.491   8.458    -27.445   1.000 17.38503 ? 914  HOH A O   1 
HETATM 3489 O  O   . HOH J 4 .   ? -6.35162  10.01565 -15.02785 1.000 34.33599 ? 915  HOH A O   1 
HETATM 3490 O  O   . HOH J 4 .   ? -6.53624  31.77332 -1.52964  1.000 38.70197 ? 916  HOH A O   1 
HETATM 3491 O  O   . HOH J 4 .   ? -33.98387 7.70468  3.12277   1.000 28.88818 ? 917  HOH A O   1 
HETATM 3492 O  O   . HOH J 4 .   ? -31.29627 21.63019 -27.19275 1.000 35.91558 ? 918  HOH A O   1 
HETATM 3493 O  O   . HOH J 4 .   ? -7.14061  29.79627 2.76112   1.000 35.98491 ? 919  HOH A O   1 
HETATM 3494 O  O   . HOH J 4 .   ? -22.91732 14.17042 -19.68349 1.000 34.39671 ? 920  HOH A O   1 
HETATM 3495 O  O   . HOH J 4 .   ? -13.173   20.732   -34.514   1.000 29.53767 ? 921  HOH A O   1 
HETATM 3496 O  O   . HOH J 4 .   ? -20.82454 44.63661 -8.61588  1.000 27.46957 ? 922  HOH A O   1 
HETATM 3497 O  O   . HOH J 4 .   ? -34.16866 9.82508  7.14191   1.000 30.10857 ? 923  HOH A O   1 
HETATM 3498 O  O   . HOH J 4 .   ? -33.84508 15.33449 12.99376  1.000 38.66108 ? 924  HOH A O   1 
HETATM 3499 O  O   . HOH J 4 .   ? -13.16791 41.62517 -1.53572  1.000 25.96464 ? 925  HOH A O   1 
HETATM 3500 O  O   . HOH J 4 .   ? 2.98838   22.27340 -9.96425  1.000 22.68828 ? 926  HOH A O   1 
HETATM 3501 O  O   . HOH J 4 .   ? -17.27521 35.83233 -0.12502  1.000 30.03122 ? 927  HOH A O   1 
HETATM 3502 O  O   . HOH J 4 .   ? -3.06773  14.41747 0.50787   1.000 37.11823 ? 928  HOH A O   1 
HETATM 3503 O  O   . HOH J 4 .   ? -14.63190 15.29035 10.63189  1.000 32.60110 ? 929  HOH A O   1 
HETATM 3504 O  O   . HOH J 4 .   ? -18.372   8.655    -16.343   1.000 22.65205 ? 930  HOH A O   1 
HETATM 3505 O  O   . HOH J 4 .   ? -43.81606 22.75454 -9.76817  1.000 33.30718 ? 931  HOH A O   1 
HETATM 3506 O  O   . HOH J 4 .   ? -8.10679  51.11465 3.19776   1.000 33.34834 ? 932  HOH A O   1 
HETATM 3507 O  O   . HOH J 4 .   ? -42.47438 23.40388 -17.21419 1.000 31.91012 ? 933  HOH A O   1 
HETATM 3508 O  O   . HOH J 4 .   ? 0.00000   20.79569 0.00000   0.50  29.51714 ? 934  HOH A O   1 
HETATM 3509 O  O   . HOH J 4 .   ? -40.33976 23.68306 13.57982  1.000 26.58768 ? 935  HOH A O   1 
HETATM 3510 O  O   . HOH J 4 .   ? -32.37507 9.73152  9.07758   1.000 31.87869 ? 936  HOH A O   1 
HETATM 3511 O  O   . HOH J 4 .   ? -26.94601 15.99386 -20.63955 1.000 33.15251 ? 937  HOH A O   1 
HETATM 3512 O  O   . HOH J 4 .   ? -38.88368 28.62154 -21.12910 1.000 25.38023 ? 938  HOH A O   1 
HETATM 3513 O  O   . HOH J 4 .   ? -41.60916 23.46673 -15.06176 1.000 26.98533 ? 939  HOH A O   1 
HETATM 3514 O  O   . HOH J 4 .   ? -10.43273 33.29437 -0.55000  1.000 33.95161 ? 940  HOH A O   1 
HETATM 3515 O  O   . HOH J 4 .   ? -39.91154 20.57032 -24.90231 1.000 45.06109 ? 941  HOH A O   1 
HETATM 3516 O  O   . HOH J 4 .   ? -8.53430  44.68029 2.05640   1.000 43.70241 ? 942  HOH A O   1 
HETATM 3517 O  O   . HOH J 4 .   ? 0.87591   40.00962 -14.97272 1.000 32.54766 ? 943  HOH A O   1 
HETATM 3518 O  O   . HOH J 4 .   ? -43.44461 27.22280 -13.81645 1.000 23.35626 ? 944  HOH A O   1 
HETATM 3519 O  O   . HOH J 4 .   ? -23.89533 34.08011 15.80677  1.000 41.38485 ? 945  HOH A O   1 
HETATM 3520 O  O   . HOH J 4 .   ? -10.62569 33.49869 1.67152   1.000 37.96161 ? 946  HOH A O   1 
HETATM 3521 O  O   . HOH J 4 .   ? -20.74512 31.94498 10.33472  1.000 26.11689 ? 947  HOH A O   1 
HETATM 3522 O  O   . HOH J 4 .   ? -16.10646 31.11808 11.09826  1.000 35.55595 ? 948  HOH A O   1 
HETATM 3523 O  O   . HOH J 4 .   ? 3.75526   55.03089 -9.81022  1.000 34.63021 ? 949  HOH A O   1 
HETATM 3524 O  O   . HOH J 4 .   ? -13.60279 29.48234 14.18920  1.000 33.37611 ? 950  HOH A O   1 
HETATM 3525 O  O   . HOH J 4 .   ? -45.37962 23.81990 -11.06715 1.000 34.53652 ? 951  HOH A O   1 
HETATM 3526 O  O   . HOH J 4 .   ? -15.17708 16.16486 12.85605  1.000 40.10880 ? 952  HOH A O   1 
HETATM 3527 O  O   . HOH J 4 .   ? -32.95245 16.09422 -19.78441 1.000 39.74829 ? 953  HOH A O   1 
HETATM 3528 O  O   . HOH J 4 .   ? -33.45498 16.56951 -17.46657 1.000 36.76386 ? 954  HOH A O   1 
HETATM 3529 O  O   . HOH J 4 .   ? 0.00000   58.03267 0.00000   0.50  31.30841 ? 955  HOH A O   1 
HETATM 3530 O  O   . HOH J 4 .   ? -3.70227  12.77127 -2.67929  1.000 31.79317 ? 956  HOH A O   1 
HETATM 3531 O  O   . HOH J 4 .   ? -20.16837 46.31423 -10.70841 1.000 28.81215 ? 957  HOH A O   1 
HETATM 3532 O  O   . HOH J 4 .   ? -1.51275  20.01162 -16.10189 1.000 35.98172 ? 958  HOH A O   1 
HETATM 3533 O  O   . HOH J 4 .   ? -1.62311  20.83705 -20.41267 1.000 32.30812 ? 959  HOH A O   1 
HETATM 3534 O  O   . HOH J 4 .   ? -0.50985  49.40555 -14.42364 1.000 34.35942 ? 960  HOH A O   1 
HETATM 3535 O  O   . HOH J 4 .   ? -24.30670 42.89070 -10.27286 1.000 32.88974 ? 961  HOH A O   1 
HETATM 3536 O  O   . HOH J 4 .   ? -15.93103 44.76666 0.34298   1.000 36.80054 ? 962  HOH A O   1 
HETATM 3537 O  O   . HOH J 4 .   ? 2.84086   40.18567 -18.56637 1.000 37.51058 ? 963  HOH A O   1 
HETATM 3538 O  O   . HOH J 4 .   ? -11.50504 41.63555 0.72457   1.000 37.78467 ? 964  HOH A O   1 
HETATM 3539 O  O   . HOH J 4 .   ? -26.470   17.507   -31.207   1.000 29.83125 ? 965  HOH A O   1 
HETATM 3540 O  O   . HOH J 4 .   ? -2.12355  49.46821 -17.94251 1.000 27.36925 ? 966  HOH A O   1 
HETATM 3541 O  O   . HOH J 4 .   ? -21.22864 35.44616 -1.62478  1.000 28.25393 ? 967  HOH A O   1 
HETATM 3542 O  O   . HOH J 4 .   ? -42.24142 25.50999 -21.04523 1.000 36.26051 ? 968  HOH A O   1 
HETATM 3543 O  O   . HOH J 4 .   ? -42.87280 11.28497 2.15009   1.000 35.24592 ? 969  HOH A O   1 
HETATM 3544 O  O   . HOH J 4 .   ? -15.46438 4.95799  -14.62211 1.000 32.12015 ? 970  HOH A O   1 
HETATM 3545 O  O   . HOH J 4 .   ? -37.70882 36.42769 12.97496  1.000 28.88430 ? 971  HOH A O   1 
HETATM 3546 O  O   . HOH J 4 .   ? -35.56697 42.55973 -17.00139 1.000 36.80657 ? 972  HOH A O   1 
HETATM 3547 O  O   . HOH J 4 .   ? -22.494   41.749   -31.739   1.000 23.86066 ? 973  HOH A O   1 
HETATM 3548 O  O   . HOH J 4 .   ? -19.31063 33.96174 -0.65667  1.000 31.80425 ? 974  HOH A O   1 
HETATM 3549 O  O   . HOH J 4 .   ? -15.00200 39.64276 -0.11438  1.000 25.06276 ? 975  HOH A O   1 
HETATM 3550 O  O   . HOH J 4 .   ? -10.88387 25.73800 -33.24149 1.000 21.54651 ? 976  HOH A O   1 
HETATM 3551 O  O   . HOH J 4 .   ? 2.98045   56.23791 -4.78328  1.000 34.82934 ? 977  HOH A O   1 
HETATM 3552 O  O   . HOH J 4 .   ? -5.51946  51.23348 -15.35003 1.000 21.64326 ? 978  HOH A O   1 
HETATM 3553 O  O   . HOH J 4 .   ? -38.57810 30.79556 -20.05672 1.000 24.28361 ? 979  HOH A O   1 
HETATM 3554 O  O   . HOH J 4 .   ? -5.98154  60.20708 -2.03346  1.000 36.58412 ? 980  HOH A O   1 
HETATM 3555 O  O   . HOH J 4 .   ? -31.79372 12.47428 9.99856   1.000 28.78912 ? 981  HOH A O   1 
HETATM 3556 O  O   . HOH J 4 .   ? -41.11023 27.52657 -21.84896 1.000 30.71765 ? 982  HOH A O   1 
HETATM 3557 O  O   . HOH J 4 .   ? 0.67086   22.17372 -18.71378 1.000 35.57489 ? 983  HOH A O   1 
HETATM 3558 O  O   . HOH J 4 .   ? -39.18861 36.36242 10.56943  1.000 25.32015 ? 984  HOH A O   1 
HETATM 3559 O  O   . HOH J 4 .   ? 0.47187   32.88725 -16.45014 1.000 32.46334 ? 985  HOH A O   1 
HETATM 3560 O  O   . HOH J 4 .   ? 2.81401   42.86977 -20.99754 1.000 37.69131 ? 986  HOH A O   1 
HETATM 3561 O  O   . HOH J 4 .   ? 1.77528   51.33613 -8.85986  1.000 28.05769 ? 987  HOH A O   1 
HETATM 3562 O  O   . HOH J 4 .   ? -34.98538 38.61075 3.61805   1.000 30.60628 ? 988  HOH A O   1 
HETATM 3563 O  O   . HOH J 4 .   ? -38.64561 34.79131 14.57737  1.000 28.76373 ? 989  HOH A O   1 
HETATM 3564 O  O   . HOH J 4 .   ? -17.78813 45.57391 -18.98316 1.000 25.15501 ? 990  HOH A O   1 
HETATM 3565 O  O   . HOH J 4 .   ? 0.69527   44.11338 -20.25298 1.000 31.41749 ? 991  HOH A O   1 
HETATM 3566 O  O   . HOH J 4 .   ? -27.00469 33.43150 15.59105  1.000 27.29025 ? 992  HOH A O   1 
HETATM 3567 O  O   . HOH J 4 .   ? -16.78147 50.55797 0.88899   1.000 41.36262 ? 993  HOH A O   1 
HETATM 3568 O  O   . HOH J 4 .   ? -1.85855  48.88099 -20.31524 1.000 31.88941 ? 994  HOH A O   1 
HETATM 3569 O  O   . HOH J 4 .   ? -21.10069 11.14808 -15.76006 1.000 31.12057 ? 995  HOH A O   1 
HETATM 3570 O  O   . HOH J 4 .   ? -35.53261 16.31449 -21.84196 1.000 48.66578 ? 996  HOH A O   1 
HETATM 3571 O  O   . HOH J 4 .   ? -22.281   22.864   -37.211   1.000 41.27200 ? 997  HOH A O   1 
HETATM 3572 O  O   . HOH J 4 .   ? -8.30091  55.44734 -14.29436 1.000 37.97410 ? 998  HOH A O   1 
HETATM 3573 O  O   . HOH J 4 .   ? -4.484    20.549   10.445    1.000 35.14512 ? 999  HOH A O   1 
HETATM 3574 O  O   . HOH J 4 .   ? -33.41636 38.71497 13.37470  1.000 32.44163 ? 1000 HOH A O   1 
HETATM 3575 O  O   . HOH J 4 .   ? -13.63664 37.64994 2.00301   1.000 36.03110 ? 1001 HOH A O   1 
HETATM 3576 O  O   . HOH J 4 .   ? -16.80535 41.84468 0.92857   1.000 45.48457 ? 1002 HOH A O   1 
HETATM 3577 O  O   . HOH J 4 .   ? -2.200    60.014   0.603     1.000 31.14709 ? 1003 HOH A O   1 
HETATM 3578 O  O   . HOH J 4 .   ? 1.30135   30.24398 -23.93777 1.000 34.08209 ? 1004 HOH A O   1 
# 
