data_9FK7
# 
_entry.id   9FK7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FK7         pdb_00009fk7 10.2210/pdb9fk7/pdb 
WWPDB D_1292139075 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FK7 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          Shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Chmelnik, O.' 2 ? 
'Dessau, M.'   3 ? 
'Shoham, Y.'   4 ? 
'Shoham, G.'   5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'The structure of XT6 from G.proteiniphilus T-6: The E265G/N158E mutant' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Chmelnik, O.' 2 ? 
primary 'Dessau, M.'   3 ? 
primary 'Shoham, Y.'   4 ? 
primary 'Shoham, G.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Endo-1,4-beta-xylanase 43815.594 1   3.2.1.8 ? ? ? 
2 non-polymer syn 'TETRAETHYLENE GLYCOL' 194.226   1   ?       ? ? ? 
3 non-polymer syn 'CHLORIDE ION'         35.453    2   ?       ? ? ? 
4 non-polymer syn 'ZINC ION'             65.409    7   ?       ? ? ? 
5 water       nat water                  18.015    429 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Xylanase,1,4-beta-D-xylan xylanohydrolase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVEEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVEEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'TETRAETHYLENE GLYCOL' PG4 
3 'CHLORIDE ION'         CL  
4 'ZINC ION'             ZN  
5 water                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   ASN n 
1 3   ALA n 
1 4   ASP n 
1 5   SER n 
1 6   TYR n 
1 7   ALA n 
1 8   LYS n 
1 9   LYS n 
1 10  PRO n 
1 11  HIS n 
1 12  ILE n 
1 13  SER n 
1 14  ALA n 
1 15  LEU n 
1 16  ASN n 
1 17  ALA n 
1 18  PRO n 
1 19  GLN n 
1 20  LEU n 
1 21  ASP n 
1 22  GLN n 
1 23  ARG n 
1 24  TYR n 
1 25  LYS n 
1 26  ASN n 
1 27  GLU n 
1 28  PHE n 
1 29  THR n 
1 30  ILE n 
1 31  GLY n 
1 32  ALA n 
1 33  ALA n 
1 34  VAL n 
1 35  GLU n 
1 36  PRO n 
1 37  TYR n 
1 38  GLN n 
1 39  LEU n 
1 40  GLN n 
1 41  ASN n 
1 42  GLU n 
1 43  LYS n 
1 44  ASP n 
1 45  VAL n 
1 46  GLN n 
1 47  MET n 
1 48  LEU n 
1 49  LYS n 
1 50  ARG n 
1 51  HIS n 
1 52  PHE n 
1 53  ASN n 
1 54  SER n 
1 55  ILE n 
1 56  VAL n 
1 57  ALA n 
1 58  GLU n 
1 59  ASN n 
1 60  VAL n 
1 61  MET n 
1 62  LYS n 
1 63  PRO n 
1 64  ILE n 
1 65  SER n 
1 66  ILE n 
1 67  GLN n 
1 68  PRO n 
1 69  GLU n 
1 70  GLU n 
1 71  GLY n 
1 72  LYS n 
1 73  PHE n 
1 74  ASN n 
1 75  PHE n 
1 76  GLU n 
1 77  GLN n 
1 78  ALA n 
1 79  ASP n 
1 80  ARG n 
1 81  ILE n 
1 82  VAL n 
1 83  LYS n 
1 84  PHE n 
1 85  ALA n 
1 86  LYS n 
1 87  ALA n 
1 88  ASN n 
1 89  GLY n 
1 90  MET n 
1 91  ASP n 
1 92  ILE n 
1 93  ARG n 
1 94  PHE n 
1 95  HIS n 
1 96  THR n 
1 97  LEU n 
1 98  VAL n 
1 99  TRP n 
1 100 HIS n 
1 101 SER n 
1 102 GLN n 
1 103 VAL n 
1 104 PRO n 
1 105 GLN n 
1 106 TRP n 
1 107 PHE n 
1 108 PHE n 
1 109 LEU n 
1 110 ASP n 
1 111 LYS n 
1 112 GLU n 
1 113 GLY n 
1 114 LYS n 
1 115 PRO n 
1 116 MET n 
1 117 VAL n 
1 118 ASN n 
1 119 GLU n 
1 120 THR n 
1 121 ASP n 
1 122 PRO n 
1 123 VAL n 
1 124 LYS n 
1 125 ARG n 
1 126 GLU n 
1 127 GLN n 
1 128 ASN n 
1 129 LYS n 
1 130 GLN n 
1 131 LEU n 
1 132 LEU n 
1 133 LEU n 
1 134 LYS n 
1 135 ARG n 
1 136 LEU n 
1 137 GLU n 
1 138 THR n 
1 139 HIS n 
1 140 ILE n 
1 141 LYS n 
1 142 THR n 
1 143 ILE n 
1 144 VAL n 
1 145 GLU n 
1 146 ARG n 
1 147 TYR n 
1 148 LYS n 
1 149 ASP n 
1 150 ASP n 
1 151 ILE n 
1 152 LYS n 
1 153 TYR n 
1 154 TRP n 
1 155 ASP n 
1 156 VAL n 
1 157 VAL n 
1 158 GLU n 
1 159 GLU n 
1 160 VAL n 
1 161 VAL n 
1 162 GLY n 
1 163 ASP n 
1 164 ASP n 
1 165 GLY n 
1 166 LYS n 
1 167 LEU n 
1 168 ARG n 
1 169 ASN n 
1 170 SER n 
1 171 PRO n 
1 172 TRP n 
1 173 TYR n 
1 174 GLN n 
1 175 ILE n 
1 176 ALA n 
1 177 GLY n 
1 178 ILE n 
1 179 ASP n 
1 180 TYR n 
1 181 ILE n 
1 182 LYS n 
1 183 VAL n 
1 184 ALA n 
1 185 PHE n 
1 186 GLN n 
1 187 ALA n 
1 188 ALA n 
1 189 ARG n 
1 190 LYS n 
1 191 TYR n 
1 192 GLY n 
1 193 GLY n 
1 194 ASP n 
1 195 ASN n 
1 196 ILE n 
1 197 LYS n 
1 198 LEU n 
1 199 TYR n 
1 200 MET n 
1 201 ASN n 
1 202 ASP n 
1 203 TYR n 
1 204 ASN n 
1 205 THR n 
1 206 GLU n 
1 207 VAL n 
1 208 GLU n 
1 209 PRO n 
1 210 LYS n 
1 211 ARG n 
1 212 THR n 
1 213 ALA n 
1 214 LEU n 
1 215 TYR n 
1 216 ASN n 
1 217 LEU n 
1 218 VAL n 
1 219 LYS n 
1 220 GLN n 
1 221 LEU n 
1 222 LYS n 
1 223 GLU n 
1 224 GLU n 
1 225 GLY n 
1 226 VAL n 
1 227 PRO n 
1 228 ILE n 
1 229 ASP n 
1 230 GLY n 
1 231 ILE n 
1 232 GLY n 
1 233 HIS n 
1 234 GLN n 
1 235 SER n 
1 236 HIS n 
1 237 ILE n 
1 238 GLN n 
1 239 ILE n 
1 240 GLY n 
1 241 TRP n 
1 242 PRO n 
1 243 SER n 
1 244 GLU n 
1 245 ALA n 
1 246 GLU n 
1 247 ILE n 
1 248 GLU n 
1 249 LYS n 
1 250 THR n 
1 251 ILE n 
1 252 ASN n 
1 253 MET n 
1 254 PHE n 
1 255 ALA n 
1 256 ALA n 
1 257 LEU n 
1 258 GLY n 
1 259 LEU n 
1 260 ASP n 
1 261 ASN n 
1 262 GLN n 
1 263 ILE n 
1 264 THR n 
1 265 GLY n 
1 266 LEU n 
1 267 ASP n 
1 268 VAL n 
1 269 SER n 
1 270 MET n 
1 271 TYR n 
1 272 GLY n 
1 273 TRP n 
1 274 PRO n 
1 275 PRO n 
1 276 ARG n 
1 277 ALA n 
1 278 TYR n 
1 279 PRO n 
1 280 THR n 
1 281 TYR n 
1 282 ASP n 
1 283 ALA n 
1 284 ILE n 
1 285 PRO n 
1 286 LYS n 
1 287 GLN n 
1 288 LYS n 
1 289 PHE n 
1 290 LEU n 
1 291 ASP n 
1 292 GLN n 
1 293 ALA n 
1 294 ALA n 
1 295 ARG n 
1 296 TYR n 
1 297 ASP n 
1 298 ARG n 
1 299 LEU n 
1 300 PHE n 
1 301 LYS n 
1 302 LEU n 
1 303 TYR n 
1 304 GLU n 
1 305 LYS n 
1 306 LEU n 
1 307 SER n 
1 308 ASP n 
1 309 LYS n 
1 310 ILE n 
1 311 SER n 
1 312 ASN n 
1 313 VAL n 
1 314 THR n 
1 315 PHE n 
1 316 TRP n 
1 317 GLY n 
1 318 ILE n 
1 319 ALA n 
1 320 ASP n 
1 321 ASN n 
1 322 HIS n 
1 323 THR n 
1 324 TRP n 
1 325 LEU n 
1 326 ASP n 
1 327 SER n 
1 328 ARG n 
1 329 ALA n 
1 330 ASP n 
1 331 VAL n 
1 332 TYR n 
1 333 TYR n 
1 334 ASP n 
1 335 ALA n 
1 336 ASN n 
1 337 GLY n 
1 338 ASN n 
1 339 VAL n 
1 340 VAL n 
1 341 VAL n 
1 342 ASP n 
1 343 PRO n 
1 344 ASN n 
1 345 ALA n 
1 346 PRO n 
1 347 TYR n 
1 348 ALA n 
1 349 LYS n 
1 350 VAL n 
1 351 GLU n 
1 352 LYS n 
1 353 GLY n 
1 354 LYS n 
1 355 GLY n 
1 356 LYS n 
1 357 ASP n 
1 358 ALA n 
1 359 PRO n 
1 360 PHE n 
1 361 VAL n 
1 362 PHE n 
1 363 GLY n 
1 364 PRO n 
1 365 ASP n 
1 366 TYR n 
1 367 LYS n 
1 368 VAL n 
1 369 LYS n 
1 370 PRO n 
1 371 ALA n 
1 372 TYR n 
1 373 TRP n 
1 374 ALA n 
1 375 ILE n 
1 376 ILE n 
1 377 ASP n 
1 378 HIS n 
1 379 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   379 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus proteiniphilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     860353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE               ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE             ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'        ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'         ? 'Cl -1'          35.453  
GLN 'L-peptide linking' y GLUTAMINE              ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'        ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE              ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                  ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE             ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                 ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE             ? 'C5 H11 N O2 S'  149.211 
PG4 non-polymer         . 'TETRAETHYLENE GLYCOL' ? 'C8 H18 O5'      194.226 
PHE 'L-peptide linking' y PHENYLALANINE          ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                 ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE              ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN             ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE               ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                 ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'             ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   ALA 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   5   SER SER A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  PRO 10  10  10  PRO PRO A . n 
A 1 11  HIS 11  11  11  HIS HIS A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLN 22  22  22  GLN GLN A . n 
A 1 23  ARG 23  23  23  ARG ARG A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  PHE 28  28  28  PHE PHE A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  PRO 36  36  36  PRO PRO A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  GLN 40  40  40  GLN GLN A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  ASP 44  44  44  ASP ASP A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  MET 61  61  61  MET MET A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  SER 65  65  65  SER SER A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  LYS 72  72  72  LYS LYS A . n 
A 1 73  PHE 73  73  73  PHE PHE A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  PHE 75  75  75  PHE PHE A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  GLN 77  77  77  GLN GLN A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  ASN 88  88  88  ASN ASN A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ARG 93  93  93  ARG ARG A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  HIS 95  95  95  HIS HIS A . n 
A 1 96  THR 96  96  96  THR THR A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  TRP 99  99  99  TRP TRP A . n 
A 1 100 HIS 100 100 100 HIS HIS A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 GLN 105 105 105 GLN GLN A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 GLU 112 112 112 GLU GLU A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 PRO 115 115 115 PRO PRO A . n 
A 1 116 MET 116 116 116 MET MET A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLU 126 126 126 GLU GLU A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 ASN 128 128 128 ASN ASN A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 ARG 135 135 135 ARG ARG A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 THR 138 138 138 THR THR A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 GLU 145 145 145 GLU GLU A . n 
A 1 146 ARG 146 146 146 ARG ARG A . n 
A 1 147 TYR 147 147 147 TYR TYR A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 ASP 149 149 149 ASP ASP A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 ILE 151 151 151 ILE ILE A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 TRP 154 154 154 TRP TRP A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 GLU 158 158 158 GLU GLU A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 LYS 166 166 166 LYS LYS A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 ASN 169 169 169 ASN ASN A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 ILE 175 175 175 ILE ILE A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 TYR 180 180 180 TYR TYR A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 GLN 186 186 186 GLN GLN A . n 
A 1 187 ALA 187 187 187 ALA ALA A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 ASN 195 195 195 ASN ASN A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 LEU 198 198 198 LEU LEU A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 MET 200 200 200 MET MET A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 GLU 206 206 206 GLU GLU A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 GLU 208 208 208 GLU GLU A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 TYR 215 215 215 TYR TYR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 LYS 219 219 219 LYS LYS A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 TRP 241 241 241 TRP TRP A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 GLU 246 246 246 GLU GLU A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 ILE 251 251 251 ILE ILE A . n 
A 1 252 ASN 252 252 252 ASN ASN A . n 
A 1 253 MET 253 253 253 MET MET A . n 
A 1 254 PHE 254 254 254 PHE PHE A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 ASN 261 261 261 ASN ASN A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 THR 264 264 264 THR THR A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 SER 269 269 269 SER SER A . n 
A 1 270 MET 270 270 270 MET MET A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 TRP 273 273 273 TRP TRP A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 PRO 275 275 275 PRO PRO A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 TYR 278 278 278 TYR TYR A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 ILE 284 284 284 ILE ILE A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 GLN 287 287 287 GLN GLN A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ASP 291 291 291 ASP ASP A . n 
A 1 292 GLN 292 292 292 GLN GLN A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 LEU 302 302 302 LEU LEU A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 SER 307 307 307 SER SER A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ILE 310 310 310 ILE ILE A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 THR 314 314 314 THR THR A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 TRP 316 316 316 TRP TRP A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ILE 318 318 318 ILE ILE A . n 
A 1 319 ALA 319 319 319 ALA ALA A . n 
A 1 320 ASP 320 320 320 ASP ASP A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 HIS 322 322 322 HIS HIS A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 TRP 324 324 324 TRP TRP A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 ARG 328 328 328 ARG ARG A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ASP 330 330 330 ASP ASP A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
A 1 332 TYR 332 332 332 TYR TYR A . n 
A 1 333 TYR 333 333 333 TYR TYR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 ASN 344 344 344 ASN ASN A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 PRO 346 346 346 PRO PRO A . n 
A 1 347 TYR 347 347 347 TYR TYR A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 GLU 351 351 351 GLU GLU A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 LYS 354 354 354 LYS LYS A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LYS 356 356 356 LYS LYS A . n 
A 1 357 ASP 357 357 357 ASP ASP A . n 
A 1 358 ALA 358 358 358 ALA ALA A . n 
A 1 359 PRO 359 359 359 PRO PRO A . n 
A 1 360 PHE 360 360 360 PHE PHE A . n 
A 1 361 VAL 361 361 361 VAL VAL A . n 
A 1 362 PHE 362 362 362 PHE PHE A . n 
A 1 363 GLY 363 363 363 GLY GLY A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 ASP 365 365 365 ASP ASP A . n 
A 1 366 TYR 366 366 366 TYR TYR A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 PRO 370 370 370 PRO PRO A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 TYR 372 372 372 TYR TYR A . n 
A 1 373 TRP 373 373 373 TRP TRP A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 ASP 377 377 377 ASP ASP A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 LYS 379 379 379 LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 PG4 1   401 401 PG4 PG4 A . 
C 3 CL  1   402 1   CL  CL  A . 
D 3 CL  1   403 2   CL  CL  A . 
E 4 ZN  1   404 1   ZN  ZN  A . 
F 4 ZN  1   405 2   ZN  ZN  A . 
G 4 ZN  1   406 3   ZN  ZN  A . 
H 4 ZN  1   407 5   ZN  ZN  A . 
I 4 ZN  1   408 6   ZN  ZN  A . 
J 4 ZN  1   409 7   ZN  ZN  A . 
K 4 ZN  1   410 8   ZN  ZN  A . 
L 5 HOH 1   501 295 HOH HOH A . 
L 5 HOH 2   502 300 HOH HOH A . 
L 5 HOH 3   503 377 HOH HOH A . 
L 5 HOH 4   504 9   HOH HOH A . 
L 5 HOH 5   505 94  HOH HOH A . 
L 5 HOH 6   506 58  HOH HOH A . 
L 5 HOH 7   507 91  HOH HOH A . 
L 5 HOH 8   508 228 HOH HOH A . 
L 5 HOH 9   509 365 HOH HOH A . 
L 5 HOH 10  510 108 HOH HOH A . 
L 5 HOH 11  511 253 HOH HOH A . 
L 5 HOH 12  512 150 HOH HOH A . 
L 5 HOH 13  513 423 HOH HOH A . 
L 5 HOH 14  514 102 HOH HOH A . 
L 5 HOH 15  515 275 HOH HOH A . 
L 5 HOH 16  516 1   HOH HOH A . 
L 5 HOH 17  517 79  HOH HOH A . 
L 5 HOH 18  518 266 HOH HOH A . 
L 5 HOH 19  519 17  HOH HOH A . 
L 5 HOH 20  520 426 HOH HOH A . 
L 5 HOH 21  521 115 HOH HOH A . 
L 5 HOH 22  522 143 HOH HOH A . 
L 5 HOH 23  523 279 HOH HOH A . 
L 5 HOH 24  524 188 HOH HOH A . 
L 5 HOH 25  525 184 HOH HOH A . 
L 5 HOH 26  526 176 HOH HOH A . 
L 5 HOH 27  527 61  HOH HOH A . 
L 5 HOH 28  528 134 HOH HOH A . 
L 5 HOH 29  529 260 HOH HOH A . 
L 5 HOH 30  530 225 HOH HOH A . 
L 5 HOH 31  531 49  HOH HOH A . 
L 5 HOH 32  532 183 HOH HOH A . 
L 5 HOH 33  533 238 HOH HOH A . 
L 5 HOH 34  534 165 HOH HOH A . 
L 5 HOH 35  535 285 HOH HOH A . 
L 5 HOH 36  536 380 HOH HOH A . 
L 5 HOH 37  537 309 HOH HOH A . 
L 5 HOH 38  538 103 HOH HOH A . 
L 5 HOH 39  539 81  HOH HOH A . 
L 5 HOH 40  540 359 HOH HOH A . 
L 5 HOH 41  541 84  HOH HOH A . 
L 5 HOH 42  542 189 HOH HOH A . 
L 5 HOH 43  543 227 HOH HOH A . 
L 5 HOH 44  544 138 HOH HOH A . 
L 5 HOH 45  545 153 HOH HOH A . 
L 5 HOH 46  546 278 HOH HOH A . 
L 5 HOH 47  547 2   HOH HOH A . 
L 5 HOH 48  548 68  HOH HOH A . 
L 5 HOH 49  549 117 HOH HOH A . 
L 5 HOH 50  550 7   HOH HOH A . 
L 5 HOH 51  551 208 HOH HOH A . 
L 5 HOH 52  552 219 HOH HOH A . 
L 5 HOH 53  553 25  HOH HOH A . 
L 5 HOH 54  554 427 HOH HOH A . 
L 5 HOH 55  555 338 HOH HOH A . 
L 5 HOH 56  556 89  HOH HOH A . 
L 5 HOH 57  557 268 HOH HOH A . 
L 5 HOH 58  558 136 HOH HOH A . 
L 5 HOH 59  559 177 HOH HOH A . 
L 5 HOH 60  560 30  HOH HOH A . 
L 5 HOH 61  561 116 HOH HOH A . 
L 5 HOH 62  562 226 HOH HOH A . 
L 5 HOH 63  563 292 HOH HOH A . 
L 5 HOH 64  564 212 HOH HOH A . 
L 5 HOH 65  565 306 HOH HOH A . 
L 5 HOH 66  566 154 HOH HOH A . 
L 5 HOH 67  567 193 HOH HOH A . 
L 5 HOH 68  568 13  HOH HOH A . 
L 5 HOH 69  569 11  HOH HOH A . 
L 5 HOH 70  570 112 HOH HOH A . 
L 5 HOH 71  571 199 HOH HOH A . 
L 5 HOH 72  572 32  HOH HOH A . 
L 5 HOH 73  573 109 HOH HOH A . 
L 5 HOH 74  574 327 HOH HOH A . 
L 5 HOH 75  575 271 HOH HOH A . 
L 5 HOH 76  576 241 HOH HOH A . 
L 5 HOH 77  577 12  HOH HOH A . 
L 5 HOH 78  578 432 HOH HOH A . 
L 5 HOH 79  579 31  HOH HOH A . 
L 5 HOH 80  580 147 HOH HOH A . 
L 5 HOH 81  581 59  HOH HOH A . 
L 5 HOH 82  582 276 HOH HOH A . 
L 5 HOH 83  583 221 HOH HOH A . 
L 5 HOH 84  584 151 HOH HOH A . 
L 5 HOH 85  585 248 HOH HOH A . 
L 5 HOH 86  586 40  HOH HOH A . 
L 5 HOH 87  587 124 HOH HOH A . 
L 5 HOH 88  588 77  HOH HOH A . 
L 5 HOH 89  589 130 HOH HOH A . 
L 5 HOH 90  590 90  HOH HOH A . 
L 5 HOH 91  591 50  HOH HOH A . 
L 5 HOH 92  592 127 HOH HOH A . 
L 5 HOH 93  593 146 HOH HOH A . 
L 5 HOH 94  594 148 HOH HOH A . 
L 5 HOH 95  595 424 HOH HOH A . 
L 5 HOH 96  596 242 HOH HOH A . 
L 5 HOH 97  597 51  HOH HOH A . 
L 5 HOH 98  598 88  HOH HOH A . 
L 5 HOH 99  599 87  HOH HOH A . 
L 5 HOH 100 600 302 HOH HOH A . 
L 5 HOH 101 601 236 HOH HOH A . 
L 5 HOH 102 602 385 HOH HOH A . 
L 5 HOH 103 603 392 HOH HOH A . 
L 5 HOH 104 604 95  HOH HOH A . 
L 5 HOH 105 605 69  HOH HOH A . 
L 5 HOH 106 606 263 HOH HOH A . 
L 5 HOH 107 607 33  HOH HOH A . 
L 5 HOH 108 608 41  HOH HOH A . 
L 5 HOH 109 609 29  HOH HOH A . 
L 5 HOH 110 610 185 HOH HOH A . 
L 5 HOH 111 611 234 HOH HOH A . 
L 5 HOH 112 612 297 HOH HOH A . 
L 5 HOH 113 613 281 HOH HOH A . 
L 5 HOH 114 614 19  HOH HOH A . 
L 5 HOH 115 615 299 HOH HOH A . 
L 5 HOH 116 616 20  HOH HOH A . 
L 5 HOH 117 617 172 HOH HOH A . 
L 5 HOH 118 618 167 HOH HOH A . 
L 5 HOH 119 619 417 HOH HOH A . 
L 5 HOH 120 620 186 HOH HOH A . 
L 5 HOH 121 621 22  HOH HOH A . 
L 5 HOH 122 622 75  HOH HOH A . 
L 5 HOH 123 623 126 HOH HOH A . 
L 5 HOH 124 624 200 HOH HOH A . 
L 5 HOH 125 625 216 HOH HOH A . 
L 5 HOH 126 626 28  HOH HOH A . 
L 5 HOH 127 627 48  HOH HOH A . 
L 5 HOH 128 628 27  HOH HOH A . 
L 5 HOH 129 629 60  HOH HOH A . 
L 5 HOH 130 630 52  HOH HOH A . 
L 5 HOH 131 631 70  HOH HOH A . 
L 5 HOH 132 632 256 HOH HOH A . 
L 5 HOH 133 633 293 HOH HOH A . 
L 5 HOH 134 634 156 HOH HOH A . 
L 5 HOH 135 635 8   HOH HOH A . 
L 5 HOH 136 636 201 HOH HOH A . 
L 5 HOH 137 637 80  HOH HOH A . 
L 5 HOH 138 638 237 HOH HOH A . 
L 5 HOH 139 639 4   HOH HOH A . 
L 5 HOH 140 640 44  HOH HOH A . 
L 5 HOH 141 641 430 HOH HOH A . 
L 5 HOH 142 642 384 HOH HOH A . 
L 5 HOH 143 643 246 HOH HOH A . 
L 5 HOH 144 644 53  HOH HOH A . 
L 5 HOH 145 645 155 HOH HOH A . 
L 5 HOH 146 646 24  HOH HOH A . 
L 5 HOH 147 647 418 HOH HOH A . 
L 5 HOH 148 648 35  HOH HOH A . 
L 5 HOH 149 649 96  HOH HOH A . 
L 5 HOH 150 650 15  HOH HOH A . 
L 5 HOH 151 651 180 HOH HOH A . 
L 5 HOH 152 652 62  HOH HOH A . 
L 5 HOH 153 653 6   HOH HOH A . 
L 5 HOH 154 654 204 HOH HOH A . 
L 5 HOH 155 655 166 HOH HOH A . 
L 5 HOH 156 656 381 HOH HOH A . 
L 5 HOH 157 657 158 HOH HOH A . 
L 5 HOH 158 658 121 HOH HOH A . 
L 5 HOH 159 659 223 HOH HOH A . 
L 5 HOH 160 660 257 HOH HOH A . 
L 5 HOH 161 661 73  HOH HOH A . 
L 5 HOH 162 662 354 HOH HOH A . 
L 5 HOH 163 663 120 HOH HOH A . 
L 5 HOH 164 664 175 HOH HOH A . 
L 5 HOH 165 665 187 HOH HOH A . 
L 5 HOH 166 666 317 HOH HOH A . 
L 5 HOH 167 667 26  HOH HOH A . 
L 5 HOH 168 668 14  HOH HOH A . 
L 5 HOH 169 669 174 HOH HOH A . 
L 5 HOH 170 670 16  HOH HOH A . 
L 5 HOH 171 671 328 HOH HOH A . 
L 5 HOH 172 672 287 HOH HOH A . 
L 5 HOH 173 673 394 HOH HOH A . 
L 5 HOH 174 674 47  HOH HOH A . 
L 5 HOH 175 675 43  HOH HOH A . 
L 5 HOH 176 676 277 HOH HOH A . 
L 5 HOH 177 677 72  HOH HOH A . 
L 5 HOH 178 678 218 HOH HOH A . 
L 5 HOH 179 679 202 HOH HOH A . 
L 5 HOH 180 680 233 HOH HOH A . 
L 5 HOH 181 681 213 HOH HOH A . 
L 5 HOH 182 682 122 HOH HOH A . 
L 5 HOH 183 683 57  HOH HOH A . 
L 5 HOH 184 684 140 HOH HOH A . 
L 5 HOH 185 685 343 HOH HOH A . 
L 5 HOH 186 686 23  HOH HOH A . 
L 5 HOH 187 687 37  HOH HOH A . 
L 5 HOH 188 688 259 HOH HOH A . 
L 5 HOH 189 689 243 HOH HOH A . 
L 5 HOH 190 690 18  HOH HOH A . 
L 5 HOH 191 691 46  HOH HOH A . 
L 5 HOH 192 692 318 HOH HOH A . 
L 5 HOH 193 693 107 HOH HOH A . 
L 5 HOH 194 694 181 HOH HOH A . 
L 5 HOH 195 695 262 HOH HOH A . 
L 5 HOH 196 696 192 HOH HOH A . 
L 5 HOH 197 697 387 HOH HOH A . 
L 5 HOH 198 698 280 HOH HOH A . 
L 5 HOH 199 699 393 HOH HOH A . 
L 5 HOH 200 700 195 HOH HOH A . 
L 5 HOH 201 701 131 HOH HOH A . 
L 5 HOH 202 702 67  HOH HOH A . 
L 5 HOH 203 703 329 HOH HOH A . 
L 5 HOH 204 704 110 HOH HOH A . 
L 5 HOH 205 705 65  HOH HOH A . 
L 5 HOH 206 706 78  HOH HOH A . 
L 5 HOH 207 707 160 HOH HOH A . 
L 5 HOH 208 708 34  HOH HOH A . 
L 5 HOH 209 709 333 HOH HOH A . 
L 5 HOH 210 710 264 HOH HOH A . 
L 5 HOH 211 711 349 HOH HOH A . 
L 5 HOH 212 712 412 HOH HOH A . 
L 5 HOH 213 713 5   HOH HOH A . 
L 5 HOH 214 714 100 HOH HOH A . 
L 5 HOH 215 715 142 HOH HOH A . 
L 5 HOH 216 716 369 HOH HOH A . 
L 5 HOH 217 717 21  HOH HOH A . 
L 5 HOH 218 718 409 HOH HOH A . 
L 5 HOH 219 719 82  HOH HOH A . 
L 5 HOH 220 720 351 HOH HOH A . 
L 5 HOH 221 721 282 HOH HOH A . 
L 5 HOH 222 722 10  HOH HOH A . 
L 5 HOH 223 723 42  HOH HOH A . 
L 5 HOH 224 724 56  HOH HOH A . 
L 5 HOH 225 725 149 HOH HOH A . 
L 5 HOH 226 726 353 HOH HOH A . 
L 5 HOH 227 727 132 HOH HOH A . 
L 5 HOH 228 728 111 HOH HOH A . 
L 5 HOH 229 729 252 HOH HOH A . 
L 5 HOH 230 730 92  HOH HOH A . 
L 5 HOH 231 731 179 HOH HOH A . 
L 5 HOH 232 732 220 HOH HOH A . 
L 5 HOH 233 733 356 HOH HOH A . 
L 5 HOH 234 734 270 HOH HOH A . 
L 5 HOH 235 735 261 HOH HOH A . 
L 5 HOH 236 736 128 HOH HOH A . 
L 5 HOH 237 737 425 HOH HOH A . 
L 5 HOH 238 738 301 HOH HOH A . 
L 5 HOH 239 739 45  HOH HOH A . 
L 5 HOH 240 740 224 HOH HOH A . 
L 5 HOH 241 741 85  HOH HOH A . 
L 5 HOH 242 742 314 HOH HOH A . 
L 5 HOH 243 743 54  HOH HOH A . 
L 5 HOH 244 744 249 HOH HOH A . 
L 5 HOH 245 745 235 HOH HOH A . 
L 5 HOH 246 746 414 HOH HOH A . 
L 5 HOH 247 747 203 HOH HOH A . 
L 5 HOH 248 748 139 HOH HOH A . 
L 5 HOH 249 749 419 HOH HOH A . 
L 5 HOH 250 750 197 HOH HOH A . 
L 5 HOH 251 751 104 HOH HOH A . 
L 5 HOH 252 752 420 HOH HOH A . 
L 5 HOH 253 753 86  HOH HOH A . 
L 5 HOH 254 754 344 HOH HOH A . 
L 5 HOH 255 755 141 HOH HOH A . 
L 5 HOH 256 756 411 HOH HOH A . 
L 5 HOH 257 757 170 HOH HOH A . 
L 5 HOH 258 758 194 HOH HOH A . 
L 5 HOH 259 759 407 HOH HOH A . 
L 5 HOH 260 760 135 HOH HOH A . 
L 5 HOH 261 761 198 HOH HOH A . 
L 5 HOH 262 762 410 HOH HOH A . 
L 5 HOH 263 763 339 HOH HOH A . 
L 5 HOH 264 764 66  HOH HOH A . 
L 5 HOH 265 765 362 HOH HOH A . 
L 5 HOH 266 766 391 HOH HOH A . 
L 5 HOH 267 767 401 HOH HOH A . 
L 5 HOH 268 768 55  HOH HOH A . 
L 5 HOH 269 769 64  HOH HOH A . 
L 5 HOH 270 770 331 HOH HOH A . 
L 5 HOH 271 771 245 HOH HOH A . 
L 5 HOH 272 772 99  HOH HOH A . 
L 5 HOH 273 773 168 HOH HOH A . 
L 5 HOH 274 774 357 HOH HOH A . 
L 5 HOH 275 775 161 HOH HOH A . 
L 5 HOH 276 776 406 HOH HOH A . 
L 5 HOH 277 777 190 HOH HOH A . 
L 5 HOH 278 778 298 HOH HOH A . 
L 5 HOH 279 779 350 HOH HOH A . 
L 5 HOH 280 780 211 HOH HOH A . 
L 5 HOH 281 781 144 HOH HOH A . 
L 5 HOH 282 782 284 HOH HOH A . 
L 5 HOH 283 783 267 HOH HOH A . 
L 5 HOH 284 784 178 HOH HOH A . 
L 5 HOH 285 785 364 HOH HOH A . 
L 5 HOH 286 786 232 HOH HOH A . 
L 5 HOH 287 787 191 HOH HOH A . 
L 5 HOH 288 788 98  HOH HOH A . 
L 5 HOH 289 789 171 HOH HOH A . 
L 5 HOH 290 790 162 HOH HOH A . 
L 5 HOH 291 791 145 HOH HOH A . 
L 5 HOH 292 792 119 HOH HOH A . 
L 5 HOH 293 793 97  HOH HOH A . 
L 5 HOH 294 794 273 HOH HOH A . 
L 5 HOH 295 795 105 HOH HOH A . 
L 5 HOH 296 796 101 HOH HOH A . 
L 5 HOH 297 797 231 HOH HOH A . 
L 5 HOH 298 798 421 HOH HOH A . 
L 5 HOH 299 799 335 HOH HOH A . 
L 5 HOH 300 800 288 HOH HOH A . 
L 5 HOH 301 801 36  HOH HOH A . 
L 5 HOH 302 802 114 HOH HOH A . 
L 5 HOH 303 803 320 HOH HOH A . 
L 5 HOH 304 804 123 HOH HOH A . 
L 5 HOH 305 805 342 HOH HOH A . 
L 5 HOH 306 806 217 HOH HOH A . 
L 5 HOH 307 807 360 HOH HOH A . 
L 5 HOH 308 808 74  HOH HOH A . 
L 5 HOH 309 809 341 HOH HOH A . 
L 5 HOH 310 810 76  HOH HOH A . 
L 5 HOH 311 811 71  HOH HOH A . 
L 5 HOH 312 812 373 HOH HOH A . 
L 5 HOH 313 813 118 HOH HOH A . 
L 5 HOH 314 814 304 HOH HOH A . 
L 5 HOH 315 815 222 HOH HOH A . 
L 5 HOH 316 816 209 HOH HOH A . 
L 5 HOH 317 817 38  HOH HOH A . 
L 5 HOH 318 818 386 HOH HOH A . 
L 5 HOH 319 819 255 HOH HOH A . 
L 5 HOH 320 820 408 HOH HOH A . 
L 5 HOH 321 821 305 HOH HOH A . 
L 5 HOH 322 822 173 HOH HOH A . 
L 5 HOH 323 823 346 HOH HOH A . 
L 5 HOH 324 824 286 HOH HOH A . 
L 5 HOH 325 825 348 HOH HOH A . 
L 5 HOH 326 826 39  HOH HOH A . 
L 5 HOH 327 827 113 HOH HOH A . 
L 5 HOH 328 828 429 HOH HOH A . 
L 5 HOH 329 829 254 HOH HOH A . 
L 5 HOH 330 830 83  HOH HOH A . 
L 5 HOH 331 831 182 HOH HOH A . 
L 5 HOH 332 832 196 HOH HOH A . 
L 5 HOH 333 833 378 HOH HOH A . 
L 5 HOH 334 834 431 HOH HOH A . 
L 5 HOH 335 835 372 HOH HOH A . 
L 5 HOH 336 836 336 HOH HOH A . 
L 5 HOH 337 837 322 HOH HOH A . 
L 5 HOH 338 838 310 HOH HOH A . 
L 5 HOH 339 839 388 HOH HOH A . 
L 5 HOH 340 840 368 HOH HOH A . 
L 5 HOH 341 841 240 HOH HOH A . 
L 5 HOH 342 842 106 HOH HOH A . 
L 5 HOH 343 843 323 HOH HOH A . 
L 5 HOH 344 844 361 HOH HOH A . 
L 5 HOH 345 845 163 HOH HOH A . 
L 5 HOH 346 846 347 HOH HOH A . 
L 5 HOH 347 847 283 HOH HOH A . 
L 5 HOH 348 848 330 HOH HOH A . 
L 5 HOH 349 849 206 HOH HOH A . 
L 5 HOH 350 850 205 HOH HOH A . 
L 5 HOH 351 851 363 HOH HOH A . 
L 5 HOH 352 852 164 HOH HOH A . 
L 5 HOH 353 853 313 HOH HOH A . 
L 5 HOH 354 854 340 HOH HOH A . 
L 5 HOH 355 855 291 HOH HOH A . 
L 5 HOH 356 856 311 HOH HOH A . 
L 5 HOH 357 857 239 HOH HOH A . 
L 5 HOH 358 858 129 HOH HOH A . 
L 5 HOH 359 859 3   HOH HOH A . 
L 5 HOH 360 860 334 HOH HOH A . 
L 5 HOH 361 861 326 HOH HOH A . 
L 5 HOH 362 862 397 HOH HOH A . 
L 5 HOH 363 863 422 HOH HOH A . 
L 5 HOH 364 864 303 HOH HOH A . 
L 5 HOH 365 865 315 HOH HOH A . 
L 5 HOH 366 866 274 HOH HOH A . 
L 5 HOH 367 867 152 HOH HOH A . 
L 5 HOH 368 868 215 HOH HOH A . 
L 5 HOH 369 869 244 HOH HOH A . 
L 5 HOH 370 870 210 HOH HOH A . 
L 5 HOH 371 871 251 HOH HOH A . 
L 5 HOH 372 872 321 HOH HOH A . 
L 5 HOH 373 873 366 HOH HOH A . 
L 5 HOH 374 874 367 HOH HOH A . 
L 5 HOH 375 875 337 HOH HOH A . 
L 5 HOH 376 876 428 HOH HOH A . 
L 5 HOH 377 877 289 HOH HOH A . 
L 5 HOH 378 878 296 HOH HOH A . 
L 5 HOH 379 879 269 HOH HOH A . 
L 5 HOH 380 880 247 HOH HOH A . 
L 5 HOH 381 881 375 HOH HOH A . 
L 5 HOH 382 882 157 HOH HOH A . 
L 5 HOH 383 883 325 HOH HOH A . 
L 5 HOH 384 884 250 HOH HOH A . 
L 5 HOH 385 885 358 HOH HOH A . 
L 5 HOH 386 886 379 HOH HOH A . 
L 5 HOH 387 887 294 HOH HOH A . 
L 5 HOH 388 888 290 HOH HOH A . 
L 5 HOH 389 889 307 HOH HOH A . 
L 5 HOH 390 890 399 HOH HOH A . 
L 5 HOH 391 891 133 HOH HOH A . 
L 5 HOH 392 892 355 HOH HOH A . 
L 5 HOH 393 893 272 HOH HOH A . 
L 5 HOH 394 894 258 HOH HOH A . 
L 5 HOH 395 895 207 HOH HOH A . 
L 5 HOH 396 896 374 HOH HOH A . 
L 5 HOH 397 897 415 HOH HOH A . 
L 5 HOH 398 898 169 HOH HOH A . 
L 5 HOH 399 899 416 HOH HOH A . 
L 5 HOH 400 900 370 HOH HOH A . 
L 5 HOH 401 901 396 HOH HOH A . 
L 5 HOH 402 902 319 HOH HOH A . 
L 5 HOH 403 903 413 HOH HOH A . 
L 5 HOH 404 904 395 HOH HOH A . 
L 5 HOH 405 905 308 HOH HOH A . 
L 5 HOH 406 906 125 HOH HOH A . 
L 5 HOH 407 907 402 HOH HOH A . 
L 5 HOH 408 908 398 HOH HOH A . 
L 5 HOH 409 909 390 HOH HOH A . 
L 5 HOH 410 910 352 HOH HOH A . 
L 5 HOH 411 911 229 HOH HOH A . 
L 5 HOH 412 912 332 HOH HOH A . 
L 5 HOH 413 913 137 HOH HOH A . 
L 5 HOH 414 914 93  HOH HOH A . 
L 5 HOH 415 915 324 HOH HOH A . 
L 5 HOH 416 916 63  HOH HOH A . 
L 5 HOH 417 917 405 HOH HOH A . 
L 5 HOH 418 918 345 HOH HOH A . 
L 5 HOH 419 919 316 HOH HOH A . 
L 5 HOH 420 920 214 HOH HOH A . 
L 5 HOH 421 921 376 HOH HOH A . 
L 5 HOH 422 922 230 HOH HOH A . 
L 5 HOH 423 923 383 HOH HOH A . 
L 5 HOH 424 924 312 HOH HOH A . 
L 5 HOH 425 925 389 HOH HOH A . 
L 5 HOH 426 926 371 HOH HOH A . 
L 5 HOH 427 927 265 HOH HOH A . 
L 5 HOH 428 928 400 HOH HOH A . 
L 5 HOH 429 929 404 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.131 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FK7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     89.000 
_cell.length_a_esd                 ? 
_cell.length_b                     61.915 
_cell.length_b_esd                 ? 
_cell.length_c                     110.912 
_cell.length_c_esd                 ? 
_cell.volume                       589979.129 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FK7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FK7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.37 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          63.46 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '14% PEG 5K, 0.1M MES buffer at pH 6.5 and 0.01M Zinc chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 200K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-09-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          16.58 
_reflns.entry_id                                       9FK7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               35.89 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29762 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.1 
_reflns.pdbx_Rpim_I_all                                0.05 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.09 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.20 
_reflns_shell.d_res_low                                     2.27 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.8 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2566 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.46 
_reflns_shell.pdbx_Rpim_I_all                               0.25 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.80 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.37 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.53 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FK7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             35.89 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29755 
_refine.ls_number_reflns_R_free                  1486 
_refine.ls_number_reflns_R_work                  28269 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.89 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1590 
_refine.ls_R_factor_R_free                       0.1988 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1570 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.6367 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1691 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        35.89 
_refine_hist.number_atoms_solvent             429 
_refine_hist.number_atoms_total               3519 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3068 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         22 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0069 ? 3163 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8242 ? 4282 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0519 ? 442  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0053 ? 556  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.5304 ? 417  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.27  . . 136 2538 99.44  . . . . 0.1920 . . . . . . . . . . . 0.2426 
'X-RAY DIFFRACTION' 2.27 2.35  . . 138 2584 99.93  . . . . 0.1804 . . . . . . . . . . . 0.2472 
'X-RAY DIFFRACTION' 2.35 2.45  . . 120 2547 100.00 . . . . 0.1763 . . . . . . . . . . . 0.2265 
'X-RAY DIFFRACTION' 2.45 2.56  . . 129 2546 99.96  . . . . 0.1678 . . . . . . . . . . . 0.2439 
'X-RAY DIFFRACTION' 2.56 2.69  . . 122 2568 99.96  . . . . 0.1722 . . . . . . . . . . . 0.2225 
'X-RAY DIFFRACTION' 2.69 2.86  . . 129 2589 100.00 . . . . 0.1681 . . . . . . . . . . . 0.1925 
'X-RAY DIFFRACTION' 2.86 3.08  . . 151 2533 100.00 . . . . 0.1743 . . . . . . . . . . . 0.2302 
'X-RAY DIFFRACTION' 3.08 3.39  . . 146 2565 100.00 . . . . 0.1639 . . . . . . . . . . . 0.1956 
'X-RAY DIFFRACTION' 3.39 3.88  . . 129 2588 100.00 . . . . 0.1466 . . . . . . . . . . . 0.2055 
'X-RAY DIFFRACTION' 3.88 4.89  . . 142 2577 100.00 . . . . 0.1234 . . . . . . . . . . . 0.1341 
'X-RAY DIFFRACTION' 4.89 35.89 . . 144 2634 99.57  . . . . 0.1375 . . . . . . . . . . . 0.1768 
# 
_struct.entry_id                     9FK7 
_struct.title                        'The structure of XT6 from G.proteiniphilus T-6: The E265G/N158E mutant' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FK7 
_struct_keywords.text            'XT6, glycosynthase, hydrolase, Geobacillus proteiniphilus T-6' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    XYN1_GEOSE 
_struct_ref.pdbx_db_accession          P40943 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITELDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_struct_ref.pdbx_align_begin           29 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FK7 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 379 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P40943 
_struct_ref_seq.db_align_beg                  29 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  407 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       379 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FK7 GLU A 158 ? UNP P40943 ASN 186 'engineered mutation' 158 1 
1 9FK7 GLY A 265 ? UNP P40943 GLU 293 'engineered mutation' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 13  ? ALA A 17  ? SER A 13  ALA A 17  5 ? 5  
HELX_P HELX_P2  AA2 GLN A 19  ? LYS A 25  ? GLN A 19  LYS A 25  1 ? 7  
HELX_P HELX_P3  AA3 GLU A 35  ? GLN A 40  ? GLU A 35  GLN A 40  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 41  ? PHE A 52  ? ASN A 41  PHE A 52  1 ? 12 
HELX_P HELX_P5  AA5 LYS A 62  ? GLN A 67  ? LYS A 62  GLN A 67  1 ? 6  
HELX_P HELX_P6  AA6 PHE A 75  ? ASN A 88  ? PHE A 75  ASN A 88  1 ? 14 
HELX_P HELX_P7  AA7 PRO A 104 ? LEU A 109 ? PRO A 104 LEU A 109 5 ? 6  
HELX_P HELX_P8  AA8 PRO A 115 ? GLU A 119 ? PRO A 115 GLU A 119 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 121 ? LYS A 148 ? ASP A 121 LYS A 148 1 ? 28 
HELX_P HELX_P10 AB1 SER A 170 ? GLY A 177 ? SER A 170 GLY A 177 1 ? 8  
HELX_P HELX_P11 AB2 ILE A 178 ? GLY A 193 ? ILE A 178 GLY A 193 1 ? 16 
HELX_P HELX_P12 AB3 PRO A 209 ? GLU A 224 ? PRO A 209 GLU A 224 1 ? 16 
HELX_P HELX_P13 AB4 SER A 243 ? LEU A 257 ? SER A 243 LEU A 257 1 ? 15 
HELX_P HELX_P14 AB5 THR A 280 ? ILE A 284 ? THR A 280 ILE A 284 5 ? 5  
HELX_P HELX_P15 AB6 PRO A 285 ? LEU A 306 ? PRO A 285 LEU A 306 1 ? 22 
HELX_P HELX_P16 AB7 THR A 323 ? ALA A 329 ? THR A 323 ALA A 329 5 ? 7  
HELX_P HELX_P17 AB8 LYS A 369 ? ASP A 377 ? LYS A 369 ASP A 377 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 11  NE2 ? ? ? 1_555 I ZN  . ZN ? ? A HIS 11  A ZN  408 4_454 ? ? ? ? ? ? ? 2.137 ? ? 
metalc2  metalc ? ? A ASP 21  OD2 ? ? ? 1_555 G ZN  . ZN ? ? A ASP 21  A ZN  406 1_555 ? ? ? ? ? ? ? 2.097 ? ? 
metalc3  metalc ? ? A GLU 27  OE2 ? ? ? 1_555 I ZN  . ZN ? ? A GLU 27  A ZN  408 1_555 ? ? ? ? ? ? ? 2.038 ? ? 
metalc4  metalc ? ? A GLU 58  OE1 ? ? ? 1_555 E ZN  . ZN ? ? A GLU 58  A ZN  404 1_555 ? ? ? ? ? ? ? 1.787 ? ? 
metalc5  metalc ? ? A LYS 62  NZ  ? ? ? 1_555 F ZN  . ZN ? ? A LYS 62  A ZN  405 1_555 ? ? ? ? ? ? ? 2.594 ? ? 
metalc6  metalc ? ? A HIS 95  NE2 ? ? ? 1_555 F ZN  . ZN ? ? A HIS 95  A ZN  405 1_555 ? ? ? ? ? ? ? 2.058 ? ? 
metalc7  metalc ? ? A GLU 158 OE1 ? ? ? 1_555 F ZN  . ZN ? ? A GLU 158 A ZN  405 1_555 ? ? ? ? ? ? ? 2.003 ? ? 
metalc8  metalc ? ? A ASP 282 OD1 ? ? ? 1_555 H ZN  . ZN ? ? A ASP 282 A ZN  407 4_454 ? ? ? ? ? ? ? 2.355 ? ? 
metalc9  metalc ? ? A ASP 282 OD2 ? ? ? 1_555 J ZN  . ZN ? ? A ASP 282 A ZN  409 4_454 ? ? ? ? ? ? ? 2.414 ? ? 
metalc10 metalc ? ? A ASP 297 OD1 ? ? ? 1_555 K ZN  . ZN ? ? A ASP 297 A ZN  410 1_555 ? ? ? ? ? ? ? 2.362 ? ? 
metalc11 metalc ? ? A HIS 322 NE2 ? ? ? 1_555 E ZN  . ZN ? ? A HIS 322 A ZN  404 1_555 ? ? ? ? ? ? ? 1.971 ? ? 
metalc12 metalc ? ? A ASP 365 OD2 ? ? ? 1_555 I ZN  . ZN ? ? A ASP 365 A ZN  408 4_454 ? ? ? ? ? ? ? 1.995 ? ? 
metalc13 metalc ? ? A ALA 374 O   ? ? ? 1_555 K ZN  . ZN ? ? A ALA 374 A ZN  410 1_555 ? ? ? ? ? ? ? 2.335 ? ? 
metalc14 metalc ? ? A ASP 377 OD1 ? ? ? 1_555 K ZN  . ZN ? ? A ASP 377 A ZN  410 1_555 ? ? ? ? ? ? ? 2.522 ? ? 
metalc15 metalc ? ? A HIS 378 NE2 ? ? ? 1_555 J ZN  . ZN ? ? A HIS 378 A ZN  409 1_555 ? ? ? ? ? ? ? 2.117 ? ? 
metalc16 metalc ? ? A LYS 379 O   ? ? ? 1_555 K ZN  . ZN ? ? A LYS 379 A ZN  410 1_555 ? ? ? ? ? ? ? 2.536 ? ? 
metalc17 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  404 A HOH 516 1_555 ? ? ? ? ? ? ? 1.954 ? ? 
metalc18 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  405 A HOH 842 1_555 ? ? ? ? ? ? ? 2.308 ? ? 
metalc19 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 547 1_555 ? ? ? ? ? ? ? 2.054 ? ? 
metalc20 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 639 1_555 ? ? ? ? ? ? ? 2.070 ? ? 
metalc21 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 713 1_555 ? ? ? ? ? ? ? 2.123 ? ? 
metalc22 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 804 1_555 ? ? ? ? ? ? ? 2.188 ? ? 
metalc23 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 859 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
metalc24 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  407 A HOH 892 4_444 ? ? ? ? ? ? ? 2.248 ? ? 
metalc25 metalc ? ? J ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  409 A HOH 524 1_555 ? ? ? ? ? ? ? 2.579 ? ? 
metalc26 metalc ? ? J ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  409 A HOH 738 4_444 ? ? ? ? ? ? ? 2.566 ? ? 
metalc27 metalc ? ? K ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  410 A HOH 534 1_555 ? ? ? ? ? ? ? 2.477 ? ? 
metalc28 metalc ? ? K ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  410 A HOH 550 1_555 ? ? ? ? ? ? ? 2.542 ? ? 
metalc29 metalc ? ? K ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  410 A HOH 653 1_555 ? ? ? ? ? ? ? 2.553 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? I ZN . ? A ZN 408 ? 4_454 OE2 ? A GLU 27  ? A GLU 27  ? 1_555 34.3  ? 
2  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? I ZN . ? A ZN 408 ? 4_454 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 118.8 ? 
3  OE2 ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? I ZN . ? A ZN 408 ? 4_454 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 97.3  ? 
4  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 547 ? 1_555 99.8  ? 
5  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 93.1  ? 
6  O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 87.4  ? 
7  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 713 ? 1_555 85.4  ? 
8  O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 713 ? 1_555 174.2 ? 
9  O   ? L HOH .   ? A HOH 639 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 713 ? 1_555 89.7  ? 
10 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 804 ? 1_555 94.8  ? 
11 O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 804 ? 1_555 89.1  ? 
12 O   ? L HOH .   ? A HOH 639 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 804 ? 1_555 171.8 ? 
13 O   ? L HOH .   ? A HOH 713 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 804 ? 1_555 93.1  ? 
14 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 859 ? 1_555 175.6 ? 
15 O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 859 ? 1_555 84.2  ? 
16 O   ? L HOH .   ? A HOH 639 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 859 ? 1_555 85.0  ? 
17 O   ? L HOH .   ? A HOH 713 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 859 ? 1_555 90.6  ? 
18 O   ? L HOH .   ? A HOH 804 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 859 ? 1_555 87.3  ? 
19 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 131.9 ? 
20 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 516 ? 1_555 86.7  ? 
21 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 516 ? 1_555 106.1 ? 
22 NZ  ? A LYS 62  ? A LYS 62  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 NE2 ? A HIS 95  ? A HIS 95  ? 1_555 97.4  ? 
23 NZ  ? A LYS 62  ? A LYS 62  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 OE1 ? A GLU 158 ? A GLU 158 ? 1_555 142.0 ? 
24 NE2 ? A HIS 95  ? A HIS 95  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 OE1 ? A GLU 158 ? A GLU 158 ? 1_555 92.7  ? 
25 NZ  ? A LYS 62  ? A LYS 62  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 842 ? 1_555 97.6  ? 
26 NE2 ? A HIS 95  ? A HIS 95  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 842 ? 1_555 117.1 ? 
27 OE1 ? A GLU 158 ? A GLU 158 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 842 ? 1_555 110.1 ? 
28 OD1 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? H ZN . ? A ZN 407 ? 4_454 O   ? L HOH .   ? A HOH 892 ? 4_444 119.8 ? 
29 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 69.8  ? 
30 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 O   ? L HOH .   ? A HOH 524 ? 1_555 69.3  ? 
31 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 O   ? L HOH .   ? A HOH 524 ? 1_555 3.5   ? 
32 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 O   ? L HOH .   ? A HOH 738 ? 4_444 70.4  ? 
33 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 O   ? L HOH .   ? A HOH 738 ? 4_444 4.9   ? 
34 O   ? L HOH .   ? A HOH 524 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 4_454 O   ? L HOH .   ? A HOH 738 ? 4_444 1.8   ? 
35 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? A ALA 374 ? A ALA 374 ? 1_555 96.1  ? 
36 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 148.0 ? 
37 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 83.5  ? 
38 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 90.1  ? 
39 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 171.8 ? 
40 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 88.4  ? 
41 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 534 ? 1_555 144.0 ? 
42 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 534 ? 1_555 92.4  ? 
43 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 534 ? 1_555 67.7  ? 
44 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 534 ? 1_555 85.7  ? 
45 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 550 ? 1_555 74.6  ? 
46 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 550 ? 1_555 86.3  ? 
47 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 550 ? 1_555 73.5  ? 
48 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 550 ? 1_555 90.1  ? 
49 O   ? L HOH .   ? A HOH 534 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 550 ? 1_555 141.0 ? 
50 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 75.3  ? 
51 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 92.5  ? 
52 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 136.7 ? 
53 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 94.3  ? 
54 O   ? L HOH .   ? A HOH 534 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 69.4  ? 
55 O   ? L HOH .   ? A HOH 550 ? 1_555 ZN ? K ZN . ? A ZN 410 ? 1_555 O   ? L HOH .   ? A HOH 653 ? 1_555 149.5 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 95  A . ? HIS 95  A THR 96  A ? THR 96  A 1 7.41  
2 GLU 208 A . ? GLU 208 A PRO 209 A ? PRO 209 A 1 6.96  
3 TRP 241 A . ? TRP 241 A PRO 242 A ? PRO 242 A 1 -8.46 
4 TRP 273 A . ? TRP 273 A PRO 274 A ? PRO 274 A 1 -1.76 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA1 2 3  ? parallel      
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? parallel      
AA1 9 10 ? parallel      
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  HIS A 236 ? ILE A 237 ? HIS A 236 ILE A 237 
AA1 2  ASP A 260 ? VAL A 268 ? ASP A 260 VAL A 268 
AA1 3  ILE A 310 ? PHE A 315 ? ILE A 310 PHE A 315 
AA1 4  THR A 29  ? VAL A 34  ? THR A 29  VAL A 34  
AA1 5  SER A 54  ? ALA A 57  ? SER A 54  ALA A 57  
AA1 6  ASP A 91  ? VAL A 98  ? ASP A 91  VAL A 98  
AA1 7  TYR A 153 ? GLU A 158 ? TYR A 153 GLU A 158 
AA1 8  LYS A 197 ? ASP A 202 ? LYS A 197 ASP A 202 
AA1 9  GLY A 230 ? HIS A 233 ? GLY A 230 HIS A 233 
AA1 10 ASP A 260 ? VAL A 268 ? ASP A 260 VAL A 268 
AA2 1  VAL A 339 ? VAL A 340 ? VAL A 339 VAL A 340 
AA2 2  VAL A 331 ? TYR A 333 ? VAL A 331 TYR A 333 
AA2 3  LYS A 349 ? GLU A 351 ? LYS A 349 GLU A 351 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ILE A 237 ? N ILE A 237 O ASP A 267 ? O ASP A 267 
AA1 2 3  N ILE A 263 ? N ILE A 263 O THR A 314 ? O THR A 314 
AA1 3 4  O PHE A 315 ? O PHE A 315 N GLY A 31  ? N GLY A 31  
AA1 4 5  N VAL A 34  ? N VAL A 34  O VAL A 56  ? O VAL A 56  
AA1 5 6  N ILE A 55  ? N ILE A 55  O ARG A 93  ? O ARG A 93  
AA1 6 7  N PHE A 94  ? N PHE A 94  O ASP A 155 ? O ASP A 155 
AA1 7 8  N TRP A 154 ? N TRP A 154 O TYR A 199 ? O TYR A 199 
AA1 8 9  N MET A 200 ? N MET A 200 O GLY A 232 ? O GLY A 232 
AA1 9 10 N HIS A 233 ? N HIS A 233 O GLN A 262 ? O GLN A 262 
AA2 1 2  O VAL A 340 ? O VAL A 340 N TYR A 332 ? N TYR A 332 
AA2 2 3  N VAL A 331 ? N VAL A 331 O GLU A 351 ? O GLU A 351 
# 
_pdbx_entry_details.entry_id                   9FK7 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O  A HOH 501 ? ? O A HOH 684 ? ? 1.86 
2 1 O  A HOH 555 ? ? O A HOH 578 ? ? 2.02 
3 1 O  A HOH 507 ? ? O A HOH 816 ? ? 2.05 
4 1 O  A HOH 849 ? ? O A HOH 899 ? ? 2.10 
5 1 NZ A LYS 134 ? ? O A HOH 501 ? ? 2.14 
6 1 O  A HOH 853 ? ? O A HOH 891 ? ? 2.16 
7 1 NZ A LYS 349 ? ? O A HOH 502 ? ? 2.16 
8 1 O  A HOH 744 ? ? O A HOH 813 ? ? 2.18 
9 1 O  A HOH 615 ? ? O A HOH 917 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 6   ? ? 55.74   70.58  
2 1 ASN A 59  ? ? -146.35 -39.33 
3 1 ILE A 318 ? ? -107.99 -65.17 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 568 ? L HOH . 
2 1 A HOH 574 ? L HOH . 
3 1 A HOH 649 ? L HOH . 
4 1 A HOH 880 ? L HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A LYS 1 ? A LYS 1 
2 1 Y 1 A ASN 2 ? A ASN 2 
3 1 Y 1 A ALA 3 ? A ALA 3 
4 1 Y 1 A ASP 4 ? A ASP 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
GLN N    N  N N 75  
GLN CA   C  N S 76  
GLN C    C  N N 77  
GLN O    O  N N 78  
GLN CB   C  N N 79  
GLN CG   C  N N 80  
GLN CD   C  N N 81  
GLN OE1  O  N N 82  
GLN NE2  N  N N 83  
GLN OXT  O  N N 84  
GLN H    H  N N 85  
GLN H2   H  N N 86  
GLN HA   H  N N 87  
GLN HB2  H  N N 88  
GLN HB3  H  N N 89  
GLN HG2  H  N N 90  
GLN HG3  H  N N 91  
GLN HE21 H  N N 92  
GLN HE22 H  N N 93  
GLN HXT  H  N N 94  
GLU N    N  N N 95  
GLU CA   C  N S 96  
GLU C    C  N N 97  
GLU O    O  N N 98  
GLU CB   C  N N 99  
GLU CG   C  N N 100 
GLU CD   C  N N 101 
GLU OE1  O  N N 102 
GLU OE2  O  N N 103 
GLU OXT  O  N N 104 
GLU H    H  N N 105 
GLU H2   H  N N 106 
GLU HA   H  N N 107 
GLU HB2  H  N N 108 
GLU HB3  H  N N 109 
GLU HG2  H  N N 110 
GLU HG3  H  N N 111 
GLU HE2  H  N N 112 
GLU HXT  H  N N 113 
GLY N    N  N N 114 
GLY CA   C  N N 115 
GLY C    C  N N 116 
GLY O    O  N N 117 
GLY OXT  O  N N 118 
GLY H    H  N N 119 
GLY H2   H  N N 120 
GLY HA2  H  N N 121 
GLY HA3  H  N N 122 
GLY HXT  H  N N 123 
HIS N    N  N N 124 
HIS CA   C  N S 125 
HIS C    C  N N 126 
HIS O    O  N N 127 
HIS CB   C  N N 128 
HIS CG   C  Y N 129 
HIS ND1  N  Y N 130 
HIS CD2  C  Y N 131 
HIS CE1  C  Y N 132 
HIS NE2  N  Y N 133 
HIS OXT  O  N N 134 
HIS H    H  N N 135 
HIS H2   H  N N 136 
HIS HA   H  N N 137 
HIS HB2  H  N N 138 
HIS HB3  H  N N 139 
HIS HD1  H  N N 140 
HIS HD2  H  N N 141 
HIS HE1  H  N N 142 
HIS HE2  H  N N 143 
HIS HXT  H  N N 144 
HOH O    O  N N 145 
HOH H1   H  N N 146 
HOH H2   H  N N 147 
ILE N    N  N N 148 
ILE CA   C  N S 149 
ILE C    C  N N 150 
ILE O    O  N N 151 
ILE CB   C  N S 152 
ILE CG1  C  N N 153 
ILE CG2  C  N N 154 
ILE CD1  C  N N 155 
ILE OXT  O  N N 156 
ILE H    H  N N 157 
ILE H2   H  N N 158 
ILE HA   H  N N 159 
ILE HB   H  N N 160 
ILE HG12 H  N N 161 
ILE HG13 H  N N 162 
ILE HG21 H  N N 163 
ILE HG22 H  N N 164 
ILE HG23 H  N N 165 
ILE HD11 H  N N 166 
ILE HD12 H  N N 167 
ILE HD13 H  N N 168 
ILE HXT  H  N N 169 
LEU N    N  N N 170 
LEU CA   C  N S 171 
LEU C    C  N N 172 
LEU O    O  N N 173 
LEU CB   C  N N 174 
LEU CG   C  N N 175 
LEU CD1  C  N N 176 
LEU CD2  C  N N 177 
LEU OXT  O  N N 178 
LEU H    H  N N 179 
LEU H2   H  N N 180 
LEU HA   H  N N 181 
LEU HB2  H  N N 182 
LEU HB3  H  N N 183 
LEU HG   H  N N 184 
LEU HD11 H  N N 185 
LEU HD12 H  N N 186 
LEU HD13 H  N N 187 
LEU HD21 H  N N 188 
LEU HD22 H  N N 189 
LEU HD23 H  N N 190 
LEU HXT  H  N N 191 
LYS N    N  N N 192 
LYS CA   C  N S 193 
LYS C    C  N N 194 
LYS O    O  N N 195 
LYS CB   C  N N 196 
LYS CG   C  N N 197 
LYS CD   C  N N 198 
LYS CE   C  N N 199 
LYS NZ   N  N N 200 
LYS OXT  O  N N 201 
LYS H    H  N N 202 
LYS H2   H  N N 203 
LYS HA   H  N N 204 
LYS HB2  H  N N 205 
LYS HB3  H  N N 206 
LYS HG2  H  N N 207 
LYS HG3  H  N N 208 
LYS HD2  H  N N 209 
LYS HD3  H  N N 210 
LYS HE2  H  N N 211 
LYS HE3  H  N N 212 
LYS HZ1  H  N N 213 
LYS HZ2  H  N N 214 
LYS HZ3  H  N N 215 
LYS HXT  H  N N 216 
MET N    N  N N 217 
MET CA   C  N S 218 
MET C    C  N N 219 
MET O    O  N N 220 
MET CB   C  N N 221 
MET CG   C  N N 222 
MET SD   S  N N 223 
MET CE   C  N N 224 
MET OXT  O  N N 225 
MET H    H  N N 226 
MET H2   H  N N 227 
MET HA   H  N N 228 
MET HB2  H  N N 229 
MET HB3  H  N N 230 
MET HG2  H  N N 231 
MET HG3  H  N N 232 
MET HE1  H  N N 233 
MET HE2  H  N N 234 
MET HE3  H  N N 235 
MET HXT  H  N N 236 
PG4 O1   O  N N 237 
PG4 C1   C  N N 238 
PG4 C2   C  N N 239 
PG4 O2   O  N N 240 
PG4 C3   C  N N 241 
PG4 C4   C  N N 242 
PG4 O3   O  N N 243 
PG4 C5   C  N N 244 
PG4 C6   C  N N 245 
PG4 O4   O  N N 246 
PG4 C7   C  N N 247 
PG4 C8   C  N N 248 
PG4 O5   O  N N 249 
PG4 HO1  H  N N 250 
PG4 H11  H  N N 251 
PG4 H12  H  N N 252 
PG4 H21  H  N N 253 
PG4 H22  H  N N 254 
PG4 H31  H  N N 255 
PG4 H32  H  N N 256 
PG4 H41  H  N N 257 
PG4 H42  H  N N 258 
PG4 H51  H  N N 259 
PG4 H52  H  N N 260 
PG4 H61  H  N N 261 
PG4 H62  H  N N 262 
PG4 H71  H  N N 263 
PG4 H72  H  N N 264 
PG4 H81  H  N N 265 
PG4 H82  H  N N 266 
PG4 HO5  H  N N 267 
PHE N    N  N N 268 
PHE CA   C  N S 269 
PHE C    C  N N 270 
PHE O    O  N N 271 
PHE CB   C  N N 272 
PHE CG   C  Y N 273 
PHE CD1  C  Y N 274 
PHE CD2  C  Y N 275 
PHE CE1  C  Y N 276 
PHE CE2  C  Y N 277 
PHE CZ   C  Y N 278 
PHE OXT  O  N N 279 
PHE H    H  N N 280 
PHE H2   H  N N 281 
PHE HA   H  N N 282 
PHE HB2  H  N N 283 
PHE HB3  H  N N 284 
PHE HD1  H  N N 285 
PHE HD2  H  N N 286 
PHE HE1  H  N N 287 
PHE HE2  H  N N 288 
PHE HZ   H  N N 289 
PHE HXT  H  N N 290 
PRO N    N  N N 291 
PRO CA   C  N S 292 
PRO C    C  N N 293 
PRO O    O  N N 294 
PRO CB   C  N N 295 
PRO CG   C  N N 296 
PRO CD   C  N N 297 
PRO OXT  O  N N 298 
PRO H    H  N N 299 
PRO HA   H  N N 300 
PRO HB2  H  N N 301 
PRO HB3  H  N N 302 
PRO HG2  H  N N 303 
PRO HG3  H  N N 304 
PRO HD2  H  N N 305 
PRO HD3  H  N N 306 
PRO HXT  H  N N 307 
SER N    N  N N 308 
SER CA   C  N S 309 
SER C    C  N N 310 
SER O    O  N N 311 
SER CB   C  N N 312 
SER OG   O  N N 313 
SER OXT  O  N N 314 
SER H    H  N N 315 
SER H2   H  N N 316 
SER HA   H  N N 317 
SER HB2  H  N N 318 
SER HB3  H  N N 319 
SER HG   H  N N 320 
SER HXT  H  N N 321 
THR N    N  N N 322 
THR CA   C  N S 323 
THR C    C  N N 324 
THR O    O  N N 325 
THR CB   C  N R 326 
THR OG1  O  N N 327 
THR CG2  C  N N 328 
THR OXT  O  N N 329 
THR H    H  N N 330 
THR H2   H  N N 331 
THR HA   H  N N 332 
THR HB   H  N N 333 
THR HG1  H  N N 334 
THR HG21 H  N N 335 
THR HG22 H  N N 336 
THR HG23 H  N N 337 
THR HXT  H  N N 338 
TRP N    N  N N 339 
TRP CA   C  N S 340 
TRP C    C  N N 341 
TRP O    O  N N 342 
TRP CB   C  N N 343 
TRP CG   C  Y N 344 
TRP CD1  C  Y N 345 
TRP CD2  C  Y N 346 
TRP NE1  N  Y N 347 
TRP CE2  C  Y N 348 
TRP CE3  C  Y N 349 
TRP CZ2  C  Y N 350 
TRP CZ3  C  Y N 351 
TRP CH2  C  Y N 352 
TRP OXT  O  N N 353 
TRP H    H  N N 354 
TRP H2   H  N N 355 
TRP HA   H  N N 356 
TRP HB2  H  N N 357 
TRP HB3  H  N N 358 
TRP HD1  H  N N 359 
TRP HE1  H  N N 360 
TRP HE3  H  N N 361 
TRP HZ2  H  N N 362 
TRP HZ3  H  N N 363 
TRP HH2  H  N N 364 
TRP HXT  H  N N 365 
TYR N    N  N N 366 
TYR CA   C  N S 367 
TYR C    C  N N 368 
TYR O    O  N N 369 
TYR CB   C  N N 370 
TYR CG   C  Y N 371 
TYR CD1  C  Y N 372 
TYR CD2  C  Y N 373 
TYR CE1  C  Y N 374 
TYR CE2  C  Y N 375 
TYR CZ   C  Y N 376 
TYR OH   O  N N 377 
TYR OXT  O  N N 378 
TYR H    H  N N 379 
TYR H2   H  N N 380 
TYR HA   H  N N 381 
TYR HB2  H  N N 382 
TYR HB3  H  N N 383 
TYR HD1  H  N N 384 
TYR HD2  H  N N 385 
TYR HE1  H  N N 386 
TYR HE2  H  N N 387 
TYR HH   H  N N 388 
TYR HXT  H  N N 389 
VAL N    N  N N 390 
VAL CA   C  N S 391 
VAL C    C  N N 392 
VAL O    O  N N 393 
VAL CB   C  N N 394 
VAL CG1  C  N N 395 
VAL CG2  C  N N 396 
VAL OXT  O  N N 397 
VAL H    H  N N 398 
VAL H2   H  N N 399 
VAL HA   H  N N 400 
VAL HB   H  N N 401 
VAL HG11 H  N N 402 
VAL HG12 H  N N 403 
VAL HG13 H  N N 404 
VAL HG21 H  N N 405 
VAL HG22 H  N N 406 
VAL HG23 H  N N 407 
VAL HXT  H  N N 408 
ZN  ZN   ZN N N 409 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PG4 O1  C1   sing N N 224 
PG4 O1  HO1  sing N N 225 
PG4 C1  C2   sing N N 226 
PG4 C1  H11  sing N N 227 
PG4 C1  H12  sing N N 228 
PG4 C2  O2   sing N N 229 
PG4 C2  H21  sing N N 230 
PG4 C2  H22  sing N N 231 
PG4 O2  C3   sing N N 232 
PG4 C3  C4   sing N N 233 
PG4 C3  H31  sing N N 234 
PG4 C3  H32  sing N N 235 
PG4 C4  O3   sing N N 236 
PG4 C4  H41  sing N N 237 
PG4 C4  H42  sing N N 238 
PG4 O3  C5   sing N N 239 
PG4 C5  C6   sing N N 240 
PG4 C5  H51  sing N N 241 
PG4 C5  H52  sing N N 242 
PG4 C6  O4   sing N N 243 
PG4 C6  H61  sing N N 244 
PG4 C6  H62  sing N N 245 
PG4 O4  C7   sing N N 246 
PG4 C7  C8   sing N N 247 
PG4 C7  H71  sing N N 248 
PG4 C7  H72  sing N N 249 
PG4 C8  O5   sing N N 250 
PG4 C8  H81  sing N N 251 
PG4 C8  H82  sing N N 252 
PG4 O5  HO5  sing N N 253 
PHE N   CA   sing N N 254 
PHE N   H    sing N N 255 
PHE N   H2   sing N N 256 
PHE CA  C    sing N N 257 
PHE CA  CB   sing N N 258 
PHE CA  HA   sing N N 259 
PHE C   O    doub N N 260 
PHE C   OXT  sing N N 261 
PHE CB  CG   sing N N 262 
PHE CB  HB2  sing N N 263 
PHE CB  HB3  sing N N 264 
PHE CG  CD1  doub Y N 265 
PHE CG  CD2  sing Y N 266 
PHE CD1 CE1  sing Y N 267 
PHE CD1 HD1  sing N N 268 
PHE CD2 CE2  doub Y N 269 
PHE CD2 HD2  sing N N 270 
PHE CE1 CZ   doub Y N 271 
PHE CE1 HE1  sing N N 272 
PHE CE2 CZ   sing Y N 273 
PHE CE2 HE2  sing N N 274 
PHE CZ  HZ   sing N N 275 
PHE OXT HXT  sing N N 276 
PRO N   CA   sing N N 277 
PRO N   CD   sing N N 278 
PRO N   H    sing N N 279 
PRO CA  C    sing N N 280 
PRO CA  CB   sing N N 281 
PRO CA  HA   sing N N 282 
PRO C   O    doub N N 283 
PRO C   OXT  sing N N 284 
PRO CB  CG   sing N N 285 
PRO CB  HB2  sing N N 286 
PRO CB  HB3  sing N N 287 
PRO CG  CD   sing N N 288 
PRO CG  HG2  sing N N 289 
PRO CG  HG3  sing N N 290 
PRO CD  HD2  sing N N 291 
PRO CD  HD3  sing N N 292 
PRO OXT HXT  sing N N 293 
SER N   CA   sing N N 294 
SER N   H    sing N N 295 
SER N   H2   sing N N 296 
SER CA  C    sing N N 297 
SER CA  CB   sing N N 298 
SER CA  HA   sing N N 299 
SER C   O    doub N N 300 
SER C   OXT  sing N N 301 
SER CB  OG   sing N N 302 
SER CB  HB2  sing N N 303 
SER CB  HB3  sing N N 304 
SER OG  HG   sing N N 305 
SER OXT HXT  sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9FK1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FK7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011236 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003038 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016151 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009340 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 5   ? -4.21220  30.47066 -25.96638 1.000 31.25963 ? 5   SER A N   1 
ATOM   2    C  CA  . SER A 1 5   ? -4.15597  29.77471 -27.24965 1.000 49.16861 ? 5   SER A CA  1 
ATOM   3    C  C   . SER A 1 5   ? -4.92213  30.44177 -28.40782 1.000 56.47687 ? 5   SER A C   1 
ATOM   4    O  O   . SER A 1 5   ? -6.11947  30.72831 -28.29790 1.000 48.58369 ? 5   SER A O   1 
ATOM   5    C  CB  . SER A 1 5   ? -4.67278  28.35058 -27.09649 1.000 28.26800 ? 5   SER A CB  1 
ATOM   6    O  OG  . SER A 1 5   ? -5.30252  27.97421 -28.31078 1.000 44.71362 ? 5   SER A OG  1 
ATOM   7    N  N   . TYR A 1 6   ? -4.19084  30.65776 -29.50756 1.000 65.02401 ? 6   TYR A N   1 
ATOM   8    C  CA  . TYR A 1 6   ? -4.68968  31.11230 -30.81441 1.000 58.28626 ? 6   TYR A CA  1 
ATOM   9    C  C   . TYR A 1 6   ? -5.46779  32.42692 -30.71393 1.000 60.48116 ? 6   TYR A C   1 
ATOM   10   O  O   . TYR A 1 6   ? -6.68465  32.49664 -30.89944 1.000 51.17722 ? 6   TYR A O   1 
ATOM   11   C  CB  . TYR A 1 6   ? -5.51226  30.01946 -31.50260 1.000 57.03671 ? 6   TYR A CB  1 
ATOM   12   C  CG  . TYR A 1 6   ? -4.62496  29.03241 -32.22177 1.000 64.38041 ? 6   TYR A CG  1 
ATOM   13   C  CD1 . TYR A 1 6   ? -4.83593  28.71334 -33.55882 1.000 64.38908 ? 6   TYR A CD1 1 
ATOM   14   C  CD2 . TYR A 1 6   ? -3.55355  28.43366 -31.56042 1.000 63.53085 ? 6   TYR A CD2 1 
ATOM   15   C  CE1 . TYR A 1 6   ? -4.00830  27.80858 -34.21146 1.000 70.52210 ? 6   TYR A CE1 1 
ATOM   16   C  CE2 . TYR A 1 6   ? -2.72815  27.53464 -32.19851 1.000 70.09239 ? 6   TYR A CE2 1 
ATOM   17   C  CZ  . TYR A 1 6   ? -2.95606  27.22284 -33.52324 1.000 75.12773 ? 6   TYR A CZ  1 
ATOM   18   O  OH  . TYR A 1 6   ? -2.12372  26.32232 -34.15316 1.000 73.67665 ? 6   TYR A OH  1 
ATOM   19   N  N   . ALA A 1 7   ? -4.69139  33.48245 -30.44395 1.000 66.59154 ? 7   ALA A N   1 
ATOM   20   C  CA  . ALA A 1 7   ? -5.14780  34.85996 -30.59768 1.000 59.73627 ? 7   ALA A CA  1 
ATOM   21   C  C   . ALA A 1 7   ? -5.31872  35.26549 -32.06180 1.000 58.58384 ? 7   ALA A C   1 
ATOM   22   O  O   . ALA A 1 7   ? -5.90850  36.32247 -32.32828 1.000 62.86802 ? 7   ALA A O   1 
ATOM   23   C  CB  . ALA A 1 7   ? -4.17469  35.81616 -29.90521 1.000 58.71564 ? 7   ALA A CB  1 
ATOM   24   N  N   . LYS A 1 8   ? -4.80578  34.46561 -33.00847 1.000 54.76318 ? 8   LYS A N   1 
ATOM   25   C  CA  . LYS A 1 8   ? -5.17721  34.62450 -34.41444 1.000 57.44242 ? 8   LYS A CA  1 
ATOM   26   C  C   . LYS A 1 8   ? -6.69229  34.54401 -34.60302 1.000 48.87508 ? 8   LYS A C   1 
ATOM   27   O  O   . LYS A 1 8   ? -7.26115  35.26090 -35.43530 1.000 48.02559 ? 8   LYS A O   1 
ATOM   28   C  CB  . LYS A 1 8   ? -4.46442  33.55027 -35.25196 1.000 58.10602 ? 8   LYS A CB  1 
ATOM   29   C  CG  . LYS A 1 8   ? -4.60753  33.64556 -36.78697 1.000 62.53424 ? 8   LYS A CG  1 
ATOM   30   C  CD  . LYS A 1 8   ? -5.94267  33.08713 -37.31458 1.000 60.07412 ? 8   LYS A CD  1 
ATOM   31   C  CE  . LYS A 1 8   ? -6.29065  31.74099 -36.67667 1.000 58.10154 ? 8   LYS A CE  1 
ATOM   32   N  NZ  . LYS A 1 8   ? -7.24286  30.96943 -37.51867 1.000 54.12739 ? 8   LYS A NZ  1 
ATOM   33   N  N   . LYS A 1 9   ? -7.35172  33.68557 -33.84307 1.000 41.63442 ? 9   LYS A N   1 
ATOM   34   C  CA  . LYS A 1 9   ? -8.75100  33.39082 -34.07965 1.000 30.21838 ? 9   LYS A CA  1 
ATOM   35   C  C   . LYS A 1 9   ? -9.61947  34.61102 -33.75512 1.000 23.44316 ? 9   LYS A C   1 
ATOM   36   O  O   . LYS A 1 9   ? -9.32204  35.35963 -32.81972 1.000 19.83628 ? 9   LYS A O   1 
ATOM   37   C  CB  . LYS A 1 9   ? -9.14506  32.17993 -33.24149 1.000 30.29302 ? 9   LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 9   ? -8.78399  30.83475 -33.89091 1.000 36.09268 ? 9   LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 9   ? -9.96760  30.29119 -34.70020 1.000 39.30651 ? 9   LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 9   ? -9.53631  29.47945 -35.90775 1.000 44.98905 ? 9   LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 9   ? -10.34865 29.86175 -37.10584 1.000 47.03032 ? 9   LYS A NZ  1 
ATOM   42   N  N   . PRO A 1 10  ? -10.68371 34.84430 -34.51583 1.000 21.11241 ? 10  PRO A N   1 
ATOM   43   C  CA  . PRO A 1 10  ? -11.35534 36.14748 -34.48559 1.000 18.21768 ? 10  PRO A CA  1 
ATOM   44   C  C   . PRO A 1 10  ? -12.34403 36.30863 -33.33322 1.000 15.60787 ? 10  PRO A C   1 
ATOM   45   O  O   . PRO A 1 10  ? -12.90227 35.35002 -32.79257 1.000 14.71033 ? 10  PRO A O   1 
ATOM   46   C  CB  . PRO A 1 10  ? -12.08300 36.18082 -35.83069 1.000 17.37326 ? 10  PRO A CB  1 
ATOM   47   C  CG  . PRO A 1 10  ? -12.43004 34.74711 -36.06399 1.000 19.40658 ? 10  PRO A CG  1 
ATOM   48   C  CD  . PRO A 1 10  ? -11.28932 33.93028 -35.50216 1.000 20.68600 ? 10  PRO A CD  1 
ATOM   49   N  N   . HIS A 1 11  ? -12.56166 37.57499 -32.98929 1.000 12.86912 ? 11  HIS A N   1 
ATOM   50   C  CA  . HIS A 1 11  ? -13.47893 38.01200 -31.93241 1.000 13.76490 ? 11  HIS A CA  1 
ATOM   51   C  C   . HIS A 1 11  ? -14.91595 38.05335 -32.46553 1.000 12.72627 ? 11  HIS A C   1 
ATOM   52   O  O   . HIS A 1 11  ? -15.55694 39.10060 -32.53700 1.000 11.97601 ? 11  HIS A O   1 
ATOM   53   C  CB  . HIS A 1 11  ? -13.00905 39.38050 -31.44877 1.000 11.49461 ? 11  HIS A CB  1 
ATOM   54   C  CG  . HIS A 1 11  ? -13.69709 39.91242 -30.22622 1.000 11.89999 ? 11  HIS A CG  1 
ATOM   55   N  ND1 . HIS A 1 11  ? -13.82088 39.19485 -29.05673 1.000 12.65210 ? 11  HIS A ND1 1 
ATOM   56   C  CD2 . HIS A 1 11  ? -14.20876 41.13925 -29.96709 1.000 10.60292 ? 11  HIS A CD2 1 
ATOM   57   C  CE1 . HIS A 1 11  ? -14.40836 39.94539 -28.14202 1.000 13.06774 ? 11  HIS A CE1 1 
ATOM   58   N  NE2 . HIS A 1 11  ? -14.65592 41.12838 -28.66913 1.000 10.65491 ? 11  HIS A NE2 1 
ATOM   59   N  N   . ILE A 1 12  ? -15.40849 36.88102 -32.87777 1.000 12.92474 ? 12  ILE A N   1 
ATOM   60   C  CA  . ILE A 1 12  ? -16.73922 36.78700 -33.47372 1.000 11.49340 ? 12  ILE A CA  1 
ATOM   61   C  C   . ILE A 1 12  ? -17.80349 36.72209 -32.37856 1.000 12.03590 ? 12  ILE A C   1 
ATOM   62   O  O   . ILE A 1 12  ? -17.53495 36.39082 -31.22134 1.000 12.07073 ? 12  ILE A O   1 
ATOM   63   C  CB  . ILE A 1 12  ? -16.85523 35.57251 -34.41473 1.000 16.12935 ? 12  ILE A CB  1 
ATOM   64   C  CG1 . ILE A 1 12  ? -16.66550 34.26951 -33.62404 1.000 16.15193 ? 12  ILE A CG1 1 
ATOM   65   C  CG2 . ILE A 1 12  ? -15.89002 35.67355 -35.59124 1.000 13.56865 ? 12  ILE A CG2 1 
ATOM   66   C  CD1 . ILE A 1 12  ? -16.92436 33.02453 -34.44112 1.000 15.87882 ? 12  ILE A CD1 1 
ATOM   67   N  N   . SER A 1 13  ? -19.03974 37.01931 -32.76872 1.000 11.11000 ? 13  SER A N   1 
ATOM   68   C  CA  . SER A 1 13  ? -20.18604 36.83272 -31.88959 1.000 15.79882 ? 13  SER A CA  1 
ATOM   69   C  C   . SER A 1 13  ? -20.26675 35.39073 -31.40314 1.000 16.18377 ? 13  SER A C   1 
ATOM   70   O  O   . SER A 1 13  ? -20.13694 34.44557 -32.19068 1.000 13.99635 ? 13  SER A O   1 
ATOM   71   C  CB  . SER A 1 13  ? -21.47793 37.21376 -32.62598 1.000 14.43637 ? 13  SER A CB  1 
ATOM   72   O  OG  . SER A 1 13  ? -22.62759 36.74463 -31.92629 1.000 16.10569 ? 13  SER A OG  1 
ATOM   73   N  N   . ALA A 1 14  ? -20.50148 35.23015 -30.09482 1.000 15.13066 ? 14  ALA A N   1 
ATOM   74   C  CA  . ALA A 1 14  ? -20.63201 33.89461 -29.52225 1.000 15.31553 ? 14  ALA A CA  1 
ATOM   75   C  C   . ALA A 1 14  ? -21.87810 33.17312 -30.01831 1.000 16.72941 ? 14  ALA A C   1 
ATOM   76   O  O   . ALA A 1 14  ? -21.92382 31.93945 -29.96857 1.000 14.25009 ? 14  ALA A O   1 
ATOM   77   C  CB  . ALA A 1 14  ? -20.63742 33.96452 -27.99364 1.000 10.27534 ? 14  ALA A CB  1 
ATOM   78   N  N   . LEU A 1 15  ? -22.87814 33.90809 -30.51281 1.000 18.28918 ? 15  LEU A N   1 
ATOM   79   C  CA  . LEU A 1 15  ? -24.04750 33.29478 -31.13488 1.000 18.84849 ? 15  LEU A CA  1 
ATOM   80   C  C   . LEU A 1 15  ? -23.72237 32.61905 -32.45756 1.000 20.15501 ? 15  LEU A C   1 
ATOM   81   O  O   . LEU A 1 15  ? -24.53111 31.83232 -32.95010 1.000 22.45030 ? 15  LEU A O   1 
ATOM   82   C  CB  . LEU A 1 15  ? -25.13053 34.35028 -31.35357 1.000 16.66417 ? 15  LEU A CB  1 
ATOM   83   C  CG  . LEU A 1 15  ? -25.51173 35.04419 -30.06378 1.000 16.99918 ? 15  LEU A CG  1 
ATOM   84   C  CD1 . LEU A 1 15  ? -26.64399 36.00776 -30.30821 1.000 28.60225 ? 15  LEU A CD1 1 
ATOM   85   C  CD2 . LEU A 1 15  ? -25.88426 33.98243 -29.03247 1.000 23.71088 ? 15  LEU A CD2 1 
ATOM   86   N  N   . ASN A 1 16  ? -22.56787 32.90772 -33.04265 1.000 22.72826 ? 16  ASN A N   1 
ATOM   87   C  CA  . ASN A 1 16  ? -22.13395 32.28816 -34.28724 1.000 27.50870 ? 16  ASN A CA  1 
ATOM   88   C  C   . ASN A 1 16  ? -20.99767 31.30624 -34.06486 1.000 29.39286 ? 16  ASN A C   1 
ATOM   89   O  O   . ASN A 1 16  ? -20.40181 30.82545 -35.03763 1.000 31.44052 ? 16  ASN A O   1 
ATOM   90   C  CB  . ASN A 1 16  ? -21.69926 33.36232 -35.28826 1.000 21.08142 ? 16  ASN A CB  1 
ATOM   91   C  CG  . ASN A 1 16  ? -22.86015 34.21530 -35.75874 1.000 34.80591 ? 16  ASN A CG  1 
ATOM   92   O  OD1 . ASN A 1 16  ? -24.00514 33.75898 -35.75331 1.000 35.90312 ? 16  ASN A OD1 1 
ATOM   93   N  ND2 . ASN A 1 16  ? -22.57595 35.46563 -36.16314 1.000 30.72038 ? 16  ASN A ND2 1 
ATOM   94   N  N   . ALA A 1 17  ? -20.66254 31.02483 -32.81020 1.000 20.61080 ? 17  ALA A N   1 
ATOM   95   C  CA  . ALA A 1 17  ? -19.50192 30.20317 -32.56012 1.000 18.09998 ? 17  ALA A CA  1 
ATOM   96   C  C   . ALA A 1 17  ? -19.90846 28.74743 -32.33486 1.000 15.33186 ? 17  ALA A C   1 
ATOM   97   O  O   . ALA A 1 17  ? -21.04635 28.46671 -31.95011 1.000 13.87425 ? 17  ALA A O   1 
ATOM   98   C  CB  . ALA A 1 17  ? -18.73449 30.72881 -31.34203 1.000 10.70814 ? 17  ALA A CB  1 
ATOM   99   N  N   . PRO A 1 18  ? -18.99805 27.81506 -32.61671 1.000 13.03212 ? 18  PRO A N   1 
ATOM   100  C  CA  . PRO A 1 18  ? -19.22965 26.41515 -32.25603 1.000 12.70797 ? 18  PRO A CA  1 
ATOM   101  C  C   . PRO A 1 18  ? -19.68613 26.26758 -30.80499 1.000 13.50239 ? 18  PRO A C   1 
ATOM   102  O  O   . PRO A 1 18  ? -19.16093 26.91752 -29.89325 1.000 9.63783  ? 18  PRO A O   1 
ATOM   103  C  CB  . PRO A 1 18  ? -17.86033 25.77304 -32.48888 1.000 10.39779 ? 18  PRO A CB  1 
ATOM   104  C  CG  . PRO A 1 18  ? -17.27961 26.57074 -33.64361 1.000 13.39586 ? 18  PRO A CG  1 
ATOM   105  C  CD  . PRO A 1 18  ? -17.80496 27.98394 -33.47054 1.000 12.72513 ? 18  PRO A CD  1 
ATOM   106  N  N   . GLN A 1 19  ? -20.66354 25.38599 -30.60735 1.000 10.62678 ? 19  GLN A N   1 
ATOM   107  C  CA  . GLN A 1 19  ? -21.31634 25.21423 -29.31265 1.000 11.86399 ? 19  GLN A CA  1 
ATOM   108  C  C   . GLN A 1 19  ? -20.39096 24.55700 -28.29269 1.000 14.72194 ? 19  GLN A C   1 
ATOM   109  O  O   . GLN A 1 19  ? -19.86896 23.45515 -28.51420 1.000 10.33101 ? 19  GLN A O   1 
ATOM   110  C  CB  . GLN A 1 19  ? -22.57725 24.37089 -29.47244 1.000 10.19250 ? 19  GLN A CB  1 
ATOM   111  C  CG  . GLN A 1 19  ? -23.63314 24.98836 -30.40147 1.000 12.70747 ? 19  GLN A CG  1 
ATOM   112  C  CD  . GLN A 1 19  ? -23.46894 24.55749 -31.84426 1.000 15.14813 ? 19  GLN A CD  1 
ATOM   113  O  OE1 . GLN A 1 19  ? -22.36671 24.21808 -32.28676 1.000 13.56336 ? 19  GLN A OE1 1 
ATOM   114  N  NE2 . GLN A 1 19  ? -24.56451 24.58554 -32.59520 1.000 16.97873 ? 19  GLN A NE2 1 
ATOM   115  N  N   . LEU A 1 20  ? -20.24064 25.22608 -27.15013 1.000 9.63129  ? 20  LEU A N   1 
ATOM   116  C  CA  . LEU A 1 20  ? -19.35864 24.75307 -26.09048 1.000 13.12725 ? 20  LEU A CA  1 
ATOM   117  C  C   . LEU A 1 20  ? -19.82779 23.41237 -25.50632 1.000 11.02677 ? 20  LEU A C   1 
ATOM   118  O  O   . LEU A 1 20  ? -19.02187 22.49609 -25.30418 1.000 10.52737 ? 20  LEU A O   1 
ATOM   119  C  CB  . LEU A 1 20  ? -19.27385 25.83660 -25.01039 1.000 9.39649  ? 20  LEU A CB  1 
ATOM   120  C  CG  . LEU A 1 20  ? -18.08940 25.81833 -24.05978 1.000 15.69195 ? 20  LEU A CG  1 
ATOM   121  C  CD1 . LEU A 1 20  ? -16.77806 25.84105 -24.82400 1.000 13.99911 ? 20  LEU A CD1 1 
ATOM   122  C  CD2 . LEU A 1 20  ? -18.17472 26.99936 -23.08677 1.000 14.30256 ? 20  LEU A CD2 1 
ATOM   123  N  N   . ASP A 1 21  ? -21.12686 23.27798 -25.20728 1.000 8.20421  ? 21  ASP A N   1 
ATOM   124  C  CA  . ASP A 1 21  ? -21.59829 22.02337 -24.61998 1.000 8.43957  ? 21  ASP A CA  1 
ATOM   125  C  C   . ASP A 1 21  ? -21.40831 20.84435 -25.58157 1.000 12.69445 ? 21  ASP A C   1 
ATOM   126  O  O   . ASP A 1 21  ? -21.06744 19.72918 -25.15559 1.000 10.57985 ? 21  ASP A O   1 
ATOM   127  C  CB  . ASP A 1 21  ? -23.06482 22.14377 -24.18321 1.000 9.42400  ? 21  ASP A CB  1 
ATOM   128  C  CG  . ASP A 1 21  ? -24.01070 22.37984 -25.34576 1.000 14.38316 ? 21  ASP A CG  1 
ATOM   129  O  OD1 . ASP A 1 21  ? -23.59318 23.01455 -26.34380 1.000 9.69820  ? 21  ASP A OD1 1 
ATOM   130  O  OD2 . ASP A 1 21  ? -25.18429 21.94246 -25.25253 1.000 14.37113 ? 21  ASP A OD2 1 
ATOM   131  N  N   . GLN A 1 22  ? -21.60313 21.07318 -26.88300 1.000 9.58424  ? 22  GLN A N   1 
ATOM   132  C  CA  . GLN A 1 22  ? -21.44127 19.99336 -27.85250 1.000 15.66484 ? 22  GLN A CA  1 
ATOM   133  C  C   . GLN A 1 22  ? -19.98676 19.56041 -27.97440 1.000 11.82978 ? 22  GLN A C   1 
ATOM   134  O  O   . GLN A 1 22  ? -19.71203 18.37997 -28.21622 1.000 14.52762 ? 22  GLN A O   1 
ATOM   135  C  CB  . GLN A 1 22  ? -21.99670 20.41754 -29.21053 1.000 11.07934 ? 22  GLN A CB  1 
ATOM   136  C  CG  . GLN A 1 22  ? -23.52213 20.43088 -29.23963 1.000 14.06082 ? 22  GLN A CG  1 
ATOM   137  C  CD  . GLN A 1 22  ? -24.08523 20.90492 -30.56415 1.000 20.85954 ? 22  GLN A CD  1 
ATOM   138  O  OE1 . GLN A 1 22  ? -23.54391 20.58776 -31.62395 1.000 20.80577 ? 22  GLN A OE1 1 
ATOM   139  N  NE2 . GLN A 1 22  ? -25.16705 21.68659 -30.51135 1.000 17.95782 ? 22  GLN A NE2 1 
ATOM   140  N  N   . ARG A 1 23  ? -19.04867 20.48004 -27.76214 1.000 10.89524 ? 23  ARG A N   1 
ATOM   141  C  CA  . ARG A 1 23  ? -17.63298 20.11958 -27.79673 1.000 11.77217 ? 23  ARG A CA  1 
ATOM   142  C  C   . ARG A 1 23  ? -17.27217 19.16939 -26.66538 1.000 13.67212 ? 23  ARG A C   1 
ATOM   143  O  O   . ARG A 1 23  ? -16.41652 18.28815 -26.84652 1.000 14.15364 ? 23  ARG A O   1 
ATOM   144  C  CB  . ARG A 1 23  ? -16.76395 21.38272 -27.74033 1.000 10.04989 ? 23  ARG A CB  1 
ATOM   145  C  CG  . ARG A 1 23  ? -15.32234 21.17226 -27.25350 1.000 9.63066  ? 23  ARG A CG  1 
ATOM   146  C  CD  . ARG A 1 23  ? -14.46537 20.37576 -28.23758 1.000 13.25288 ? 23  ARG A CD  1 
ATOM   147  N  NE  . ARG A 1 23  ? -13.07949 20.29444 -27.78336 1.000 14.05531 ? 23  ARG A NE  1 
ATOM   148  C  CZ  . ARG A 1 23  ? -12.64473 19.41487 -26.88551 1.000 15.03128 ? 23  ARG A CZ  1 
ATOM   149  N  NH1 . ARG A 1 23  ? -13.49593 18.54078 -26.35394 1.000 14.81834 ? 23  ARG A NH1 1 
ATOM   150  N  NH2 . ARG A 1 23  ? -11.36676 19.41149 -26.51141 1.000 10.91566 ? 23  ARG A NH2 1 
ATOM   151  N  N   . TYR A 1 24  ? -17.94450 19.29827 -25.51953 1.000 10.26896 ? 24  TYR A N   1 
ATOM   152  C  CA  . TYR A 1 24  ? -17.64282 18.51657 -24.32370 1.000 12.57303 ? 24  TYR A CA  1 
ATOM   153  C  C   . TYR A 1 24  ? -18.70983 17.47748 -23.97716 1.000 11.57822 ? 24  TYR A C   1 
ATOM   154  O  O   . TYR A 1 24  ? -18.59530 16.82695 -22.93598 1.000 10.80499 ? 24  TYR A O   1 
ATOM   155  C  CB  . TYR A 1 24  ? -17.42603 19.45617 -23.13184 1.000 9.20270  ? 24  TYR A CB  1 
ATOM   156  C  CG  . TYR A 1 24  ? -16.11469 20.18539 -23.23482 1.000 9.84267  ? 24  TYR A CG  1 
ATOM   157  C  CD1 . TYR A 1 24  ? -14.91811 19.53608 -22.95248 1.000 10.38110 ? 24  TYR A CD1 1 
ATOM   158  C  CD2 . TYR A 1 24  ? -16.06564 21.51423 -23.65864 1.000 8.89081  ? 24  TYR A CD2 1 
ATOM   159  C  CE1 . TYR A 1 24  ? -13.69693 20.19990 -23.08776 1.000 13.90141 ? 24  TYR A CE1 1 
ATOM   160  C  CE2 . TYR A 1 24  ? -14.86185 22.17613 -23.80004 1.000 9.78728  ? 24  TYR A CE2 1 
ATOM   161  C  CZ  . TYR A 1 24  ? -13.68012 21.52017 -23.51103 1.000 11.93908 ? 24  TYR A CZ  1 
ATOM   162  O  OH  . TYR A 1 24  ? -12.48021 22.17996 -23.66162 1.000 9.20211  ? 24  TYR A OH  1 
ATOM   163  N  N   . LYS A 1 25  ? -19.71014 17.26651 -24.84341 1.000 14.33851 ? 25  LYS A N   1 
ATOM   164  C  CA  . LYS A 1 25  ? -20.90092 16.49660 -24.47041 1.000 17.56043 ? 25  LYS A CA  1 
ATOM   165  C  C   . LYS A 1 25  ? -20.61965 15.04861 -24.05157 1.000 20.28807 ? 25  LYS A C   1 
ATOM   166  O  O   . LYS A 1 25  ? -21.45976 14.45723 -23.36864 1.000 16.56487 ? 25  LYS A O   1 
ATOM   167  C  CB  . LYS A 1 25  ? -21.91448 16.48724 -25.61698 1.000 16.53034 ? 25  LYS A CB  1 
ATOM   168  C  CG  . LYS A 1 25  ? -21.46580 15.69057 -26.84483 1.000 19.36582 ? 25  LYS A CG  1 
ATOM   169  C  CD  . LYS A 1 25  ? -22.59560 15.59522 -27.84946 1.000 24.14942 ? 25  LYS A CD  1 
ATOM   170  C  CE  . LYS A 1 25  ? -22.09571 15.23156 -29.23942 1.000 23.80104 ? 25  LYS A CE  1 
ATOM   171  N  NZ  . LYS A 1 25  ? -21.38378 16.34839 -29.90463 1.000 28.74193 ? 25  LYS A NZ  1 
ATOM   172  N  N   . ASN A 1 26  ? -19.49222 14.44457 -24.43859 1.000 13.61659 ? 26  ASN A N   1 
ATOM   173  C  CA  . ASN A 1 26  ? -19.21023 13.10345 -23.92110 1.000 12.76455 ? 26  ASN A CA  1 
ATOM   174  C  C   . ASN A 1 26  ? -18.34581 13.11507 -22.66682 1.000 14.82158 ? 26  ASN A C   1 
ATOM   175  O  O   . ASN A 1 26  ? -18.21181 12.06926 -22.01421 1.000 11.42343 ? 26  ASN A O   1 
ATOM   176  C  CB  . ASN A 1 26  ? -18.52540 12.23944 -24.98531 1.000 14.21824 ? 26  ASN A CB  1 
ATOM   177  C  CG  . ASN A 1 26  ? -19.36511 12.09434 -26.23722 1.000 19.51774 ? 26  ASN A CG  1 
ATOM   178  O  OD1 . ASN A 1 26  ? -20.58501 11.92854 -26.16804 1.000 16.72847 ? 26  ASN A OD1 1 
ATOM   179  N  ND2 . ASN A 1 26  ? -18.71735 12.17311 -27.39237 1.000 16.38028 ? 26  ASN A ND2 1 
ATOM   180  N  N   . GLU A 1 27  ? -17.76364 14.26551 -22.31776 1.000 10.60213 ? 27  GLU A N   1 
ATOM   181  C  CA  . GLU A 1 27  ? -16.86415 14.39479 -21.17888 1.000 12.30718 ? 27  GLU A CA  1 
ATOM   182  C  C   . GLU A 1 27  ? -17.57100 14.85918 -19.90693 1.000 12.40187 ? 27  GLU A C   1 
ATOM   183  O  O   . GLU A 1 27  ? -17.34505 14.28852 -18.83170 1.000 15.76959 ? 27  GLU A O   1 
ATOM   184  C  CB  . GLU A 1 27  ? -15.72799 15.36204 -21.53146 1.000 11.17535 ? 27  GLU A CB  1 
ATOM   185  C  CG  . GLU A 1 27  ? -15.32249 15.36509 -23.00597 1.000 14.53757 ? 27  GLU A CG  1 
ATOM   186  C  CD  . GLU A 1 27  ? -15.00477 13.97727 -23.54266 1.000 14.48968 ? 27  GLU A CD  1 
ATOM   187  O  OE1 . GLU A 1 27  ? -14.44737 13.15896 -22.78015 1.000 11.70718 ? 27  GLU A OE1 1 
ATOM   188  O  OE2 . GLU A 1 27  ? -15.33194 13.70894 -24.71814 1.000 14.06525 ? 27  GLU A OE2 1 
ATOM   189  N  N   . PHE A 1 28  ? -18.40979 15.89314 -20.00119 1.000 9.87849  ? 28  PHE A N   1 
ATOM   190  C  CA  . PHE A 1 28  ? -19.17603 16.42512 -18.87542 1.000 10.72634 ? 28  PHE A CA  1 
ATOM   191  C  C   . PHE A 1 28  ? -20.12827 17.47529 -19.43541 1.000 12.07046 ? 28  PHE A C   1 
ATOM   192  O  O   . PHE A 1 28  ? -19.89782 17.99910 -20.52749 1.000 10.10123 ? 28  PHE A O   1 
ATOM   193  C  CB  . PHE A 1 28  ? -18.25410 17.02407 -17.79158 1.000 7.93647  ? 28  PHE A CB  1 
ATOM   194  C  CG  . PHE A 1 28  ? -17.00901 17.68159 -18.34330 1.000 10.05262 ? 28  PHE A CG  1 
ATOM   195  C  CD1 . PHE A 1 28  ? -17.08595 18.89815 -19.01159 1.000 10.68911 ? 28  PHE A CD1 1 
ATOM   196  C  CD2 . PHE A 1 28  ? -15.75991 17.07691 -18.20604 1.000 11.36621 ? 28  PHE A CD2 1 
ATOM   197  C  CE1 . PHE A 1 28  ? -15.93986 19.50316 -19.53596 1.000 12.14010 ? 28  PHE A CE1 1 
ATOM   198  C  CE2 . PHE A 1 28  ? -14.61073 17.67333 -18.71075 1.000 10.12877 ? 28  PHE A CE2 1 
ATOM   199  C  CZ  . PHE A 1 28  ? -14.69808 18.89558 -19.37901 1.000 11.06427 ? 28  PHE A CZ  1 
ATOM   200  N  N   . THR A 1 29  ? -21.20100 17.77872 -18.69225 1.000 8.68883  ? 29  THR A N   1 
ATOM   201  C  CA  . THR A 1 29  ? -22.07007 18.87863 -19.10083 1.000 7.45946  ? 29  THR A CA  1 
ATOM   202  C  C   . THR A 1 29  ? -21.37804 20.22946 -18.86214 1.000 11.19918 ? 29  THR A C   1 
ATOM   203  O  O   . THR A 1 29  ? -20.42107 20.34019 -18.08837 1.000 9.99948  ? 29  THR A O   1 
ATOM   204  C  CB  . THR A 1 29  ? -23.40197 18.84803 -18.34621 1.000 10.56272 ? 29  THR A CB  1 
ATOM   205  O  OG1 . THR A 1 29  ? -23.14849 18.88006 -16.94002 1.000 11.02951 ? 29  THR A OG1 1 
ATOM   206  C  CG2 . THR A 1 29  ? -24.21835 17.58918 -18.70503 1.000 14.79094 ? 29  THR A CG2 1 
ATOM   207  N  N   . ILE A 1 30  ? -21.86846 21.26392 -19.55164 1.000 8.65066  ? 30  ILE A N   1 
ATOM   208  C  CA  . ILE A 1 30  ? -21.32863 22.61907 -19.45751 1.000 9.44687  ? 30  ILE A CA  1 
ATOM   209  C  C   . ILE A 1 30  ? -22.44309 23.51759 -18.94164 1.000 8.26775  ? 30  ILE A C   1 
ATOM   210  O  O   . ILE A 1 30  ? -23.48054 23.66272 -19.59752 1.000 8.42857  ? 30  ILE A O   1 
ATOM   211  C  CB  . ILE A 1 30  ? -20.79627 23.13801 -20.80808 1.000 9.75954  ? 30  ILE A CB  1 
ATOM   212  C  CG1 . ILE A 1 30  ? -19.63112 22.28880 -21.32099 1.000 9.55032  ? 30  ILE A CG1 1 
ATOM   213  C  CG2 . ILE A 1 30  ? -20.36342 24.61911 -20.69298 1.000 7.76834  ? 30  ILE A CG2 1 
ATOM   214  C  CD1 . ILE A 1 30  ? -18.32776 22.47309 -20.54490 1.000 8.55755  ? 30  ILE A CD1 1 
ATOM   215  N  N   . GLY A 1 31  ? -22.22587 24.13427 -17.78287 1.000 8.14741  ? 31  GLY A N   1 
ATOM   216  C  CA  . GLY A 1 31  ? -23.29055 24.86618 -17.13016 1.000 8.72536  ? 31  GLY A CA  1 
ATOM   217  C  C   . GLY A 1 31  ? -23.03286 26.35051 -16.95582 1.000 11.93370 ? 31  GLY A C   1 
ATOM   218  O  O   . GLY A 1 31  ? -21.88808 26.79796 -17.04384 1.000 9.75252  ? 31  GLY A O   1 
ATOM   219  N  N   . ALA A 1 32  ? -24.09612 27.11325 -16.68952 1.000 10.35109 ? 32  ALA A N   1 
ATOM   220  C  CA  . ALA A 1 32  ? -24.01610 28.53287 -16.39760 1.000 9.52280  ? 32  ALA A CA  1 
ATOM   221  C  C   . ALA A 1 32  ? -24.90372 28.84161 -15.20592 1.000 10.62751 ? 32  ALA A C   1 
ATOM   222  O  O   . ALA A 1 32  ? -26.01543 28.31307 -15.10387 1.000 10.03587 ? 32  ALA A O   1 
ATOM   223  C  CB  . ALA A 1 32  ? -24.45354 29.38433 -17.59677 1.000 8.77217  ? 32  ALA A CB  1 
ATOM   224  N  N   . ALA A 1 33  ? -24.40891 29.70947 -14.31388 1.000 9.86618  ? 33  ALA A N   1 
ATOM   225  C  CA  . ALA A 1 33  ? -25.19613 30.25250 -13.21163 1.000 8.03653  ? 33  ALA A CA  1 
ATOM   226  C  C   . ALA A 1 33  ? -25.92978 31.50571 -13.67247 1.000 11.02640 ? 33  ALA A C   1 
ATOM   227  O  O   . ALA A 1 33  ? -25.36185 32.34123 -14.38017 1.000 11.15192 ? 33  ALA A O   1 
ATOM   228  C  CB  . ALA A 1 33  ? -24.29809 30.58380 -12.01785 1.000 8.70872  ? 33  ALA A CB  1 
ATOM   229  N  N   . VAL A 1 34  ? -27.19978 31.64032 -13.27821 1.000 10.10956 ? 34  VAL A N   1 
ATOM   230  C  CA  . VAL A 1 34  ? -28.05081 32.68972 -13.82630 1.000 10.97619 ? 34  VAL A CA  1 
ATOM   231  C  C   . VAL A 1 34  ? -28.89234 33.36398 -12.74182 1.000 17.35322 ? 34  VAL A C   1 
ATOM   232  O  O   . VAL A 1 34  ? -29.09730 32.83748 -11.64297 1.000 13.45954 ? 34  VAL A O   1 
ATOM   233  C  CB  . VAL A 1 34  ? -28.98425 32.15458 -14.93939 1.000 10.26777 ? 34  VAL A CB  1 
ATOM   234  C  CG1 . VAL A 1 34  ? -28.18541 31.41733 -16.04203 1.000 7.56240  ? 34  VAL A CG1 1 
ATOM   235  C  CG2 . VAL A 1 34  ? -30.04861 31.24316 -14.34263 1.000 9.78992  ? 34  VAL A CG2 1 
ATOM   236  N  N   . GLU A 1 35  ? -29.36925 34.57030 -13.07861 1.000 13.01677 ? 35  GLU A N   1 
ATOM   237  C  CA  . GLU A 1 35  ? -30.41028 35.33058 -12.42596 1.000 15.88633 ? 35  GLU A CA  1 
ATOM   238  C  C   . GLU A 1 35  ? -31.65241 35.32437 -13.30668 1.000 16.75630 ? 35  GLU A C   1 
ATOM   239  O  O   . GLU A 1 35  ? -31.54274 35.29752 -14.53540 1.000 13.82000 ? 35  GLU A O   1 
ATOM   240  C  CB  . GLU A 1 35  ? -29.97175 36.78084 -12.17362 1.000 20.14146 ? 35  GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 35  ? -28.81704 36.91739 -11.19915 1.000 19.27808 ? 35  GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 35  ? -29.26372 36.84303 -9.73377  1.000 25.81198 ? 35  GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 35  ? -30.31019 36.21809 -9.42176  1.000 21.48579 ? 35  GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 35  ? -28.55196 37.41263 -8.88466  1.000 29.25412 ? 35  GLU A OE2 1 
ATOM   245  N  N   . PRO A 1 36  ? -32.84805 35.33999 -12.72354 1.000 21.53674 ? 36  PRO A N   1 
ATOM   246  C  CA  . PRO A 1 36  ? -34.05471 35.24798 -13.56529 1.000 23.20516 ? 36  PRO A CA  1 
ATOM   247  C  C   . PRO A 1 36  ? -34.15644 36.34573 -14.60870 1.000 15.50060 ? 36  PRO A C   1 
ATOM   248  O  O   . PRO A 1 36  ? -34.63881 36.07956 -15.71800 1.000 16.12650 ? 36  PRO A O   1 
ATOM   249  C  CB  . PRO A 1 36  ? -35.19850 35.30765 -12.54133 1.000 26.50701 ? 36  PRO A CB  1 
ATOM   250  C  CG  . PRO A 1 36  ? -34.58092 34.74096 -11.28568 1.000 26.51325 ? 36  PRO A CG  1 
ATOM   251  C  CD  . PRO A 1 36  ? -33.16997 35.27951 -11.28772 1.000 24.06659 ? 36  PRO A CD  1 
ATOM   252  N  N   . TYR A 1 37  ? -33.68367 37.55844 -14.31226 1.000 16.67375 ? 37  TYR A N   1 
ATOM   253  C  CA  . TYR A 1 37  ? -33.76586 38.62212 -15.31130 1.000 21.54778 ? 37  TYR A CA  1 
ATOM   254  C  C   . TYR A 1 37  ? -33.07910 38.21168 -16.61107 1.000 18.77706 ? 37  TYR A C   1 
ATOM   255  O  O   . TYR A 1 37  ? -33.48717 38.64945 -17.68866 1.000 19.84688 ? 37  TYR A O   1 
ATOM   256  C  CB  . TYR A 1 37  ? -33.18487 39.94015 -14.75345 1.000 17.90386 ? 37  TYR A CB  1 
ATOM   257  C  CG  . TYR A 1 37  ? -31.68603 40.15351 -14.95338 1.000 18.85703 ? 37  TYR A CG  1 
ATOM   258  C  CD1 . TYR A 1 37  ? -31.16123 40.48232 -16.20042 1.000 17.28991 ? 37  TYR A CD1 1 
ATOM   259  C  CD2 . TYR A 1 37  ? -30.80287 40.05681 -13.88198 1.000 19.70842 ? 37  TYR A CD2 1 
ATOM   260  C  CE1 . TYR A 1 37  ? -29.79169 40.67172 -16.38624 1.000 24.24293 ? 37  TYR A CE1 1 
ATOM   261  C  CE2 . TYR A 1 37  ? -29.43237 40.25110 -14.05415 1.000 18.34122 ? 37  TYR A CE2 1 
ATOM   262  C  CZ  . TYR A 1 37  ? -28.92989 40.55626 -15.30253 1.000 24.28722 ? 37  TYR A CZ  1 
ATOM   263  O  OH  . TYR A 1 37  ? -27.56554 40.74422 -15.48052 1.000 31.02646 ? 37  TYR A OH  1 
ATOM   264  N  N   . GLN A 1 38  ? -32.06001 37.34923 -16.53990 1.000 14.41094 ? 38  GLN A N   1 
ATOM   265  C  CA  . GLN A 1 38  ? -31.36173 36.95296 -17.75914 1.000 16.28873 ? 38  GLN A CA  1 
ATOM   266  C  C   . GLN A 1 38  ? -32.21090 36.04432 -18.65052 1.000 16.99667 ? 38  GLN A C   1 
ATOM   267  O  O   . GLN A 1 38  ? -31.92955 35.93534 -19.84818 1.000 17.59426 ? 38  GLN A O   1 
ATOM   268  C  CB  . GLN A 1 38  ? -30.02266 36.29001 -17.39873 1.000 13.72843 ? 38  GLN A CB  1 
ATOM   269  C  CG  . GLN A 1 38  ? -29.08648 37.22565 -16.62809 1.000 12.21771 ? 38  GLN A CG  1 
ATOM   270  C  CD  . GLN A 1 38  ? -27.85729 36.52915 -16.06774 1.000 13.64890 ? 38  GLN A CD  1 
ATOM   271  O  OE1 . GLN A 1 38  ? -27.95104 35.46276 -15.47393 1.000 18.11187 ? 38  GLN A OE1 1 
ATOM   272  N  NE2 . GLN A 1 38  ? -26.69985 37.13884 -16.24556 1.000 13.06384 ? 38  GLN A NE2 1 
ATOM   273  N  N   . LEU A 1 39  ? -33.25674 35.41214 -18.11569 1.000 18.24326 ? 39  LEU A N   1 
ATOM   274  C  CA  . LEU A 1 39  ? -34.18069 34.64484 -18.95457 1.000 18.27697 ? 39  LEU A CA  1 
ATOM   275  C  C   . LEU A 1 39  ? -35.15249 35.52779 -19.72532 1.000 20.28927 ? 39  LEU A C   1 
ATOM   276  O  O   . LEU A 1 39  ? -35.92863 35.01356 -20.54286 1.000 20.64388 ? 39  LEU A O   1 
ATOM   277  C  CB  . LEU A 1 39  ? -34.97901 33.65310 -18.10129 1.000 14.64351 ? 39  LEU A CB  1 
ATOM   278  C  CG  . LEU A 1 39  ? -34.08885 32.77857 -17.22453 1.000 17.30270 ? 39  LEU A CG  1 
ATOM   279  C  CD1 . LEU A 1 39  ? -34.93128 31.87079 -16.32740 1.000 15.80836 ? 39  LEU A CD1 1 
ATOM   280  C  CD2 . LEU A 1 39  ? -33.10090 31.97148 -18.08953 1.000 12.87266 ? 39  LEU A CD2 1 
ATOM   281  N  N   . GLN A 1 40  ? -35.15095 36.82931 -19.45709 1.000 18.52460 ? 40  GLN A N   1 
ATOM   282  C  CA  . GLN A 1 40  ? -35.95412 37.79362 -20.18311 1.000 22.11190 ? 40  GLN A CA  1 
ATOM   283  C  C   . GLN A 1 40  ? -35.10596 38.64397 -21.10741 1.000 25.57492 ? 40  GLN A C   1 
ATOM   284  O  O   . GLN A 1 40  ? -35.62441 39.57330 -21.72442 1.000 24.25800 ? 40  GLN A O   1 
ATOM   285  C  CB  . GLN A 1 40  ? -36.71235 38.68967 -19.19975 1.000 27.75828 ? 40  GLN A CB  1 
ATOM   286  C  CG  . GLN A 1 40  ? -37.75977 37.93837 -18.37458 1.000 30.96511 ? 40  GLN A CG  1 
ATOM   287  C  CD  . GLN A 1 40  ? -38.05905 38.62988 -17.04650 1.000 47.89896 ? 40  GLN A CD  1 
ATOM   288  O  OE1 . GLN A 1 40  ? -37.17974 38.78112 -16.18950 1.000 45.95946 ? 40  GLN A OE1 1 
ATOM   289  N  NE2 . GLN A 1 40  ? -39.30565 39.06701 -16.87756 1.000 56.31437 ? 40  GLN A NE2 1 
ATOM   290  N  N   . ASN A 1 41  ? -33.81362 38.35061 -21.20220 1.000 21.28174 ? 41  ASN A N   1 
ATOM   291  C  CA  . ASN A 1 41  ? -32.87254 39.08236 -22.02971 1.000 25.48863 ? 41  ASN A CA  1 
ATOM   292  C  C   . ASN A 1 41  ? -32.53348 38.23664 -23.24937 1.000 22.83080 ? 41  ASN A C   1 
ATOM   293  O  O   . ASN A 1 41  ? -32.09775 37.09016 -23.10686 1.000 20.37204 ? 41  ASN A O   1 
ATOM   294  C  CB  . ASN A 1 41  ? -31.60996 39.40583 -21.22998 1.000 20.68431 ? 41  ASN A CB  1 
ATOM   295  C  CG  . ASN A 1 41  ? -30.60798 40.14347 -22.04677 1.000 35.14027 ? 41  ASN A CG  1 
ATOM   296  O  OD1 . ASN A 1 41  ? -29.53226 39.62306 -22.35542 1.000 35.90876 ? 41  ASN A OD1 1 
ATOM   297  N  ND2 . ASN A 1 41  ? -30.95958 41.36614 -22.44356 1.000 45.49622 ? 41  ASN A ND2 1 
ATOM   298  N  N   . GLU A 1 42  ? -32.72423 38.80024 -24.44497 1.000 21.74829 ? 42  GLU A N   1 
ATOM   299  C  CA  . GLU A 1 42  ? -32.60855 37.99191 -25.65372 1.000 19.95566 ? 42  GLU A CA  1 
ATOM   300  C  C   . GLU A 1 42  ? -31.21458 37.39131 -25.80836 1.000 19.20130 ? 42  GLU A C   1 
ATOM   301  O  O   . GLU A 1 42  ? -31.08129 36.20881 -26.14291 1.000 18.20483 ? 42  GLU A O   1 
ATOM   302  C  CB  . GLU A 1 42  ? -32.96768 38.81447 -26.88432 1.000 27.56209 ? 42  GLU A CB  1 
ATOM   303  C  CG  . GLU A 1 42  ? -32.74310 38.06302 -28.18585 1.000 32.74837 ? 42  GLU A CG  1 
ATOM   304  C  CD  . GLU A 1 42  ? -33.17427 38.85799 -29.41238 1.000 56.10299 ? 42  GLU A CD  1 
ATOM   305  O  OE1 . GLU A 1 42  ? -34.37405 39.20714 -29.50455 1.000 66.20545 ? 42  GLU A OE1 1 
ATOM   306  O  OE2 . GLU A 1 42  ? -32.31455 39.13266 -30.28174 1.000 52.13848 ? 42  GLU A OE2 1 
ATOM   307  N  N   . LYS A 1 43  ? -30.16236 38.18185 -25.57834 1.000 16.77588 ? 43  LYS A N   1 
ATOM   308  C  CA  . LYS A 1 43  ? -28.81061 37.66393 -25.79769 1.000 21.37772 ? 43  LYS A CA  1 
ATOM   309  C  C   . LYS A 1 43  ? -28.46395 36.56833 -24.79414 1.000 17.16078 ? 43  LYS A C   1 
ATOM   310  O  O   . LYS A 1 43  ? -27.88505 35.54061 -25.16582 1.000 12.49616 ? 43  LYS A O   1 
ATOM   311  C  CB  . LYS A 1 43  ? -27.77934 38.79586 -25.72692 1.000 21.89128 ? 43  LYS A CB  1 
ATOM   312  C  CG  . LYS A 1 43  ? -27.73720 39.65427 -26.99715 1.000 33.33076 ? 43  LYS A CG  1 
ATOM   313  C  CD  . LYS A 1 43  ? -26.83102 40.88012 -26.83276 1.000 40.56687 ? 43  LYS A CD  1 
ATOM   314  C  CE  . LYS A 1 43  ? -27.01023 41.89095 -27.97962 1.000 46.77698 ? 43  LYS A CE  1 
ATOM   315  N  NZ  . LYS A 1 43  ? -27.22874 41.24626 -29.31587 1.000 51.22067 ? 43  LYS A NZ  1 
ATOM   316  N  N   . ASP A 1 44  ? -28.81223 36.76765 -23.51881 1.000 13.88219 ? 44  ASP A N   1 
ATOM   317  C  CA  . ASP A 1 44  ? -28.54455 35.74832 -22.50914 1.000 15.95965 ? 44  ASP A CA  1 
ATOM   318  C  C   . ASP A 1 44  ? -29.31265 34.46896 -22.81210 1.000 15.02858 ? 44  ASP A C   1 
ATOM   319  O  O   . ASP A 1 44  ? -28.76729 33.36658 -22.69214 1.000 13.73872 ? 44  ASP A O   1 
ATOM   320  C  CB  . ASP A 1 44  ? -28.91016 36.27534 -21.12209 1.000 13.67866 ? 44  ASP A CB  1 
ATOM   321  C  CG  . ASP A 1 44  ? -27.90567 37.27766 -20.59156 1.000 13.62351 ? 44  ASP A CG  1 
ATOM   322  O  OD1 . ASP A 1 44  ? -26.71164 37.21091 -20.96004 1.000 9.75570  ? 44  ASP A OD1 1 
ATOM   323  O  OD2 . ASP A 1 44  ? -28.31300 38.13158 -19.78197 1.000 10.89997 ? 44  ASP A OD2 1 
ATOM   324  N  N   . VAL A 1 45  ? -30.57979 34.59758 -23.21431 1.000 12.79129 ? 45  VAL A N   1 
ATOM   325  C  CA  . VAL A 1 45  ? -31.37180 33.42235 -23.56164 1.000 13.06834 ? 45  VAL A CA  1 
ATOM   326  C  C   . VAL A 1 45  ? -30.73100 32.67547 -24.72874 1.000 12.77776 ? 45  VAL A C   1 
ATOM   327  O  O   . VAL A 1 45  ? -30.59368 31.44792 -24.70271 1.000 12.09509 ? 45  VAL A O   1 
ATOM   328  C  CB  . VAL A 1 45  ? -32.82756 33.82581 -23.86983 1.000 15.47563 ? 45  VAL A CB  1 
ATOM   329  C  CG1 . VAL A 1 45  ? -33.55263 32.70638 -24.60405 1.000 11.12708 ? 45  VAL A CG1 1 
ATOM   330  C  CG2 . VAL A 1 45  ? -33.57460 34.19310 -22.56818 1.000 12.78930 ? 45  VAL A CG2 1 
ATOM   331  N  N   . GLN A 1 46  ? -30.31557 33.40257 -25.76866 1.000 14.02501 ? 46  GLN A N   1 
ATOM   332  C  CA  . GLN A 1 46  ? -29.66211 32.72963 -26.89325 1.000 15.63750 ? 46  GLN A CA  1 
ATOM   333  C  C   . GLN A 1 46  ? -28.31127 32.13043 -26.49439 1.000 12.30481 ? 46  GLN A C   1 
ATOM   334  O  O   . GLN A 1 46  ? -27.92696 31.06860 -27.00423 1.000 11.83949 ? 46  GLN A O   1 
ATOM   335  C  CB  . GLN A 1 46  ? -29.51067 33.69663 -28.07280 1.000 16.82670 ? 46  GLN A CB  1 
ATOM   336  C  CG  . GLN A 1 46  ? -30.85600 34.04699 -28.75261 1.000 22.77900 ? 46  GLN A CG  1 
ATOM   337  C  CD  . GLN A 1 46  ? -31.74675 32.81626 -29.08294 1.000 35.25366 ? 46  GLN A CD  1 
ATOM   338  O  OE1 . GLN A 1 46  ? -31.30614 31.85492 -29.73136 1.000 29.20973 ? 46  GLN A OE1 1 
ATOM   339  N  NE2 . GLN A 1 46  ? -33.00696 32.85758 -28.63284 1.000 32.02251 ? 46  GLN A NE2 1 
ATOM   340  N  N   . MET A 1 47  ? -27.58482 32.77322 -25.57912 1.000 11.09697 ? 47  MET A N   1 
ATOM   341  C  CA  . MET A 1 47  ? -26.34078 32.18252 -25.08986 1.000 10.86749 ? 47  MET A CA  1 
ATOM   342  C  C   . MET A 1 47  ? -26.60992 30.85882 -24.38135 1.000 13.33466 ? 47  MET A C   1 
ATOM   343  O  O   . MET A 1 47  ? -25.90616 29.86246 -24.59992 1.000 9.63960  ? 47  MET A O   1 
ATOM   344  C  CB  . MET A 1 47  ? -25.63268 33.15522 -24.14982 1.000 10.94833 ? 47  MET A CB  1 
ATOM   345  C  CG  . MET A 1 47  ? -24.97095 34.32728 -24.86291 1.000 10.01235 ? 47  MET A CG  1 
ATOM   346  S  SD  . MET A 1 47  ? -23.59490 33.81608 -25.90719 1.000 11.29118 ? 47  MET A SD  1 
ATOM   347  C  CE  . MET A 1 47  ? -22.36575 33.36672 -24.66791 1.000 7.57496  ? 47  MET A CE  1 
ATOM   348  N  N   . LEU A 1 48  ? -27.62960 30.83162 -23.51480 1.000 10.93724 ? 48  LEU A N   1 
ATOM   349  C  CA  . LEU A 1 48  ? -27.93301 29.60392 -22.78960 1.000 11.64531 ? 48  LEU A CA  1 
ATOM   350  C  C   . LEU A 1 48  ? -28.38650 28.49923 -23.73845 1.000 9.87743  ? 48  LEU A C   1 
ATOM   351  O  O   . LEU A 1 48  ? -27.99296 27.33527 -23.58072 1.000 8.80941  ? 48  LEU A O   1 
ATOM   352  C  CB  . LEU A 1 48  ? -28.99922 29.87750 -21.72644 1.000 11.27501 ? 48  LEU A CB  1 
ATOM   353  C  CG  . LEU A 1 48  ? -28.52547 30.76709 -20.58092 1.000 12.29314 ? 48  LEU A CG  1 
ATOM   354  C  CD1 . LEU A 1 48  ? -29.71410 31.36854 -19.85183 1.000 10.79513 ? 48  LEU A CD1 1 
ATOM   355  C  CD2 . LEU A 1 48  ? -27.63661 29.96646 -19.62751 1.000 7.04026  ? 48  LEU A CD2 1 
ATOM   356  N  N   . LYS A 1 49  ? -29.21536 28.84865 -24.73216 1.000 9.62267  ? 49  LYS A N   1 
ATOM   357  C  CA  . LYS A 1 49  ? -29.70311 27.85791 -25.69092 1.000 14.66898 ? 49  LYS A CA  1 
ATOM   358  C  C   . LYS A 1 49  ? -28.56719 27.30045 -26.52957 1.000 12.88586 ? 49  LYS A C   1 
ATOM   359  O  O   . LYS A 1 49  ? -28.53872 26.09943 -26.82119 1.000 11.99012 ? 49  LYS A O   1 
ATOM   360  C  CB  . LYS A 1 49  ? -30.76155 28.46953 -26.61394 1.000 13.71351 ? 49  LYS A CB  1 
ATOM   361  C  CG  . LYS A 1 49  ? -32.10707 28.69584 -25.95453 1.000 15.90729 ? 49  LYS A CG  1 
ATOM   362  C  CD  . LYS A 1 49  ? -33.11764 29.32203 -26.90996 1.000 18.45165 ? 49  LYS A CD  1 
ATOM   363  C  CE  . LYS A 1 49  ? -34.52279 29.30637 -26.30212 1.000 20.45710 ? 49  LYS A CE  1 
ATOM   364  N  NZ  . LYS A 1 49  ? -35.47599 30.14811 -27.07939 1.000 26.19860 ? 49  LYS A NZ  1 
ATOM   365  N  N   . ARG A 1 50  ? -27.62136 28.16162 -26.92364 1.000 10.94347 ? 50  ARG A N   1 
ATOM   366  C  CA  . ARG A 1 50  ? -26.57151 27.75193 -27.84853 1.000 11.34797 ? 50  ARG A CA  1 
ATOM   367  C  C   . ARG A 1 50  ? -25.46124 26.95705 -27.17041 1.000 11.52573 ? 50  ARG A C   1 
ATOM   368  O  O   . ARG A 1 50  ? -24.97644 25.97171 -27.73907 1.000 12.63240 ? 50  ARG A O   1 
ATOM   369  C  CB  . ARG A 1 50  ? -25.95833 28.96863 -28.54988 1.000 12.04944 ? 50  ARG A CB  1 
ATOM   370  C  CG  . ARG A 1 50  ? -24.83954 28.56742 -29.51660 1.000 13.92049 ? 50  ARG A CG  1 
ATOM   371  C  CD  . ARG A 1 50  ? -24.65189 29.56743 -30.62501 1.000 19.66967 ? 50  ARG A CD  1 
ATOM   372  N  NE  . ARG A 1 50  ? -23.72815 29.09508 -31.65305 1.000 24.71608 ? 50  ARG A NE  1 
ATOM   373  C  CZ  . ARG A 1 50  ? -24.08442 28.39823 -32.72931 1.000 25.97510 ? 50  ARG A CZ  1 
ATOM   374  N  NH1 . ARG A 1 50  ? -25.35346 28.07574 -32.92953 1.000 26.61170 ? 50  ARG A NH1 1 
ATOM   375  N  NH2 . ARG A 1 50  ? -23.16480 28.02975 -33.61655 1.000 22.39438 ? 50  ARG A NH2 1 
ATOM   376  N  N   . HIS A 1 51  ? -25.01996 27.36483 -25.97628 1.000 9.76277  ? 51  HIS A N   1 
ATOM   377  C  CA  . HIS A 1 51  ? -23.74141 26.87322 -25.46326 1.000 8.69095  ? 51  HIS A CA  1 
ATOM   378  C  C   . HIS A 1 51  ? -23.83080 25.97280 -24.23491 1.000 9.25386  ? 51  HIS A C   1 
ATOM   379  O  O   . HIS A 1 51  ? -22.84230 25.30664 -23.91435 1.000 9.44963  ? 51  HIS A O   1 
ATOM   380  C  CB  . HIS A 1 51  ? -22.81741 28.05634 -25.13746 1.000 8.55093  ? 51  HIS A CB  1 
ATOM   381  C  CG  . HIS A 1 51  ? -22.21420 28.69788 -26.34974 1.000 10.50929 ? 51  HIS A CG  1 
ATOM   382  N  ND1 . HIS A 1 51  ? -21.26855 28.07043 -27.13459 1.000 11.10615 ? 51  HIS A ND1 1 
ATOM   383  C  CD2 . HIS A 1 51  ? -22.43514 29.90855 -26.91983 1.000 10.13209 ? 51  HIS A CD2 1 
ATOM   384  C  CE1 . HIS A 1 51  ? -20.92852 28.86863 -28.13272 1.000 13.66783 ? 51  HIS A CE1 1 
ATOM   385  N  NE2 . HIS A 1 51  ? -21.62308 29.98975 -28.02609 1.000 11.86821 ? 51  HIS A NE2 1 
ATOM   386  N  N   . PHE A 1 52  ? -24.96456 25.91625 -23.54544 1.000 8.76209  ? 52  PHE A N   1 
ATOM   387  C  CA  . PHE A 1 52  ? -25.00104 25.30909 -22.22526 1.000 8.27218  ? 52  PHE A CA  1 
ATOM   388  C  C   . PHE A 1 52  ? -26.04917 24.21106 -22.17000 1.000 10.63292 ? 52  PHE A C   1 
ATOM   389  O  O   . PHE A 1 52  ? -27.10438 24.31591 -22.80148 1.000 9.85359  ? 52  PHE A O   1 
ATOM   390  C  CB  . PHE A 1 52  ? -25.27548 26.37537 -21.14692 1.000 9.26559  ? 52  PHE A CB  1 
ATOM   391  C  CG  . PHE A 1 52  ? -24.18126 27.41239 -21.03828 1.000 9.75534  ? 52  PHE A CG  1 
ATOM   392  C  CD1 . PHE A 1 52  ? -23.03704 27.14994 -20.31487 1.000 6.52762  ? 52  PHE A CD1 1 
ATOM   393  C  CD2 . PHE A 1 52  ? -24.30918 28.64699 -21.66153 1.000 9.31694  ? 52  PHE A CD2 1 
ATOM   394  C  CE1 . PHE A 1 52  ? -22.02155 28.10424 -20.22166 1.000 11.01941 ? 52  PHE A CE1 1 
ATOM   395  C  CE2 . PHE A 1 52  ? -23.30952 29.59820 -21.58429 1.000 11.61876 ? 52  PHE A CE2 1 
ATOM   396  C  CZ  . PHE A 1 52  ? -22.15625 29.32882 -20.85549 1.000 12.56746 ? 52  PHE A CZ  1 
ATOM   397  N  N   . ASN A 1 53  ? -25.76423 23.15286 -21.40242 1.000 7.94331  ? 53  ASN A N   1 
ATOM   398  C  CA  . ASN A 1 53  ? -26.76618 22.11035 -21.20306 1.000 10.40611 ? 53  ASN A CA  1 
ATOM   399  C  C   . ASN A 1 53  ? -26.96985 21.80576 -19.72328 1.000 9.78347  ? 53  ASN A C   1 
ATOM   400  O  O   . ASN A 1 53  ? -27.46947 20.73454 -19.38101 1.000 11.91384 ? 53  ASN A O   1 
ATOM   401  C  CB  . ASN A 1 53  ? -26.40326 20.83503 -21.97921 1.000 10.23529 ? 53  ASN A CB  1 
ATOM   402  C  CG  . ASN A 1 53  ? -25.01833 20.32568 -21.65624 1.000 11.99858 ? 53  ASN A CG  1 
ATOM   403  O  OD1 . ASN A 1 53  ? -24.34970 20.85153 -20.77134 1.000 14.06457 ? 53  ASN A OD1 1 
ATOM   404  N  ND2 . ASN A 1 53  ? -24.57370 19.29454 -22.37715 1.000 11.30992 ? 53  ASN A ND2 1 
ATOM   405  N  N   . SER A 1 54  ? -26.57391 22.72021 -18.84107 1.000 9.03562  ? 54  SER A N   1 
ATOM   406  C  CA  . SER A 1 54  ? -26.84668 22.59055 -17.42279 1.000 8.49437  ? 54  SER A CA  1 
ATOM   407  C  C   . SER A 1 54  ? -26.97245 24.01222 -16.88415 1.000 10.69175 ? 54  SER A C   1 
ATOM   408  O  O   . SER A 1 54  ? -26.39278 24.95169 -17.44346 1.000 10.30307 ? 54  SER A O   1 
ATOM   409  C  CB  . SER A 1 54  ? -25.74098 21.78149 -16.71741 1.000 10.12131 ? 54  SER A CB  1 
ATOM   410  O  OG  . SER A 1 54  ? -25.79868 21.87165 -15.29314 1.000 14.46760 ? 54  SER A OG  1 
ATOM   411  N  N   . ILE A 1 55  ? -27.74999 24.17783 -15.81391 1.000 7.92529  ? 55  ILE A N   1 
ATOM   412  C  CA  . ILE A 1 55  ? -28.05609 25.50453 -15.29260 1.000 10.40133 ? 55  ILE A CA  1 
ATOM   413  C  C   . ILE A 1 55  ? -28.14788 25.43144 -13.77194 1.000 11.69072 ? 55  ILE A C   1 
ATOM   414  O  O   . ILE A 1 55  ? -28.43735 24.37761 -13.19411 1.000 11.82398 ? 55  ILE A O   1 
ATOM   415  C  CB  . ILE A 1 55  ? -29.36916 26.06086 -15.90358 1.000 9.56009  ? 55  ILE A CB  1 
ATOM   416  C  CG1 . ILE A 1 55  ? -29.42999 27.58841 -15.74644 1.000 10.26145 ? 55  ILE A CG1 1 
ATOM   417  C  CG2 . ILE A 1 55  ? -30.59994 25.36545 -15.26702 1.000 8.86362  ? 55  ILE A CG2 1 
ATOM   418  C  CD1 . ILE A 1 55  ? -30.43920 28.28208 -16.66912 1.000 10.86216 ? 55  ILE A CD1 1 
ATOM   419  N  N   . VAL A 1 56  ? -27.88311 26.56824 -13.12952 1.000 9.92301  ? 56  VAL A N   1 
ATOM   420  C  CA  . VAL A 1 56  ? -27.94473 26.71858 -11.68114 1.000 8.09047  ? 56  VAL A CA  1 
ATOM   421  C  C   . VAL A 1 56  ? -28.28604 28.18009 -11.39611 1.000 8.95275  ? 56  VAL A C   1 
ATOM   422  O  O   . VAL A 1 56  ? -27.98695 29.07022 -12.19825 1.000 11.14715 ? 56  VAL A O   1 
ATOM   423  C  CB  . VAL A 1 56  ? -26.60314 26.29172 -11.02209 1.000 11.87052 ? 56  VAL A CB  1 
ATOM   424  C  CG1 . VAL A 1 56  ? -25.47263 27.19960 -11.49123 1.000 9.55316  ? 56  VAL A CG1 1 
ATOM   425  C  CG2 . VAL A 1 56  ? -26.68321 26.29360 -9.49633  1.000 6.70261  ? 56  VAL A CG2 1 
ATOM   426  N  N   . ALA A 1 57  ? -28.94689 28.43023 -10.26610 1.000 11.26458 ? 57  ALA A N   1 
ATOM   427  C  CA  . ALA A 1 57  ? -29.27884 29.79374 -9.85256  1.000 9.27190  ? 57  ALA A CA  1 
ATOM   428  C  C   . ALA A 1 57  ? -28.12816 30.39035 -9.05530  1.000 9.87011  ? 57  ALA A C   1 
ATOM   429  O  O   . ALA A 1 57  ? -27.63136 29.75924 -8.11729  1.000 11.31306 ? 57  ALA A O   1 
ATOM   430  C  CB  . ALA A 1 57  ? -30.54992 29.80892 -9.00354  1.000 10.00684 ? 57  ALA A CB  1 
ATOM   431  N  N   . GLU A 1 58  ? -27.69927 31.60636 -9.40733  1.000 8.65549  ? 58  GLU A N   1 
ATOM   432  C  CA  . GLU A 1 58  ? -26.63811 32.15126 -8.57319  1.000 17.63755 ? 58  GLU A CA  1 
ATOM   433  C  C   . GLU A 1 58  ? -27.15707 32.65074 -7.22688  1.000 19.44988 ? 58  GLU A C   1 
ATOM   434  O  O   . GLU A 1 58  ? -26.36697 32.73403 -6.28085  1.000 18.15878 ? 58  GLU A O   1 
ATOM   435  C  CB  . GLU A 1 58  ? -25.81154 33.22334 -9.32155  1.000 17.82156 ? 58  GLU A CB  1 
ATOM   436  C  CG  . GLU A 1 58  ? -26.54105 34.31774 -10.05239 1.000 26.52088 ? 58  GLU A CG  1 
ATOM   437  C  CD  . GLU A 1 58  ? -25.62569 35.50332 -10.41478 1.000 28.64596 ? 58  GLU A CD  1 
ATOM   438  O  OE1 . GLU A 1 58  ? -25.85648 36.58762 -9.83610  1.000 30.93429 ? 58  GLU A OE1 1 
ATOM   439  O  OE2 . GLU A 1 58  ? -24.71838 35.38169 -11.27880 1.000 19.27655 ? 58  GLU A OE2 1 
ATOM   440  N  N   . ASN A 1 59  ? -28.47068 32.87753 -7.07845  1.000 16.38521 ? 59  ASN A N   1 
ATOM   441  C  CA  . ASN A 1 59  ? -28.97055 33.44353 -5.82685  1.000 15.83775 ? 59  ASN A CA  1 
ATOM   442  C  C   . ASN A 1 59  ? -30.34712 32.97612 -5.38367  1.000 16.09505 ? 59  ASN A C   1 
ATOM   443  O  O   . ASN A 1 59  ? -30.57281 32.80473 -4.18298  1.000 19.48763 ? 59  ASN A O   1 
ATOM   444  C  CB  . ASN A 1 59  ? -29.01974 34.96611 -5.91932  1.000 21.32435 ? 59  ASN A CB  1 
ATOM   445  C  CG  . ASN A 1 59  ? -27.67186 35.58103 -5.77332  1.000 22.48128 ? 59  ASN A CG  1 
ATOM   446  O  OD1 . ASN A 1 59  ? -27.03106 35.44124 -4.73294  1.000 28.92170 ? 59  ASN A OD1 1 
ATOM   447  N  ND2 . ASN A 1 59  ? -27.21671 36.26189 -6.81572  1.000 23.01997 ? 59  ASN A ND2 1 
ATOM   448  N  N   . VAL A 1 60  ? -31.29387 32.81207 -6.31540  1.000 14.58024 ? 60  VAL A N   1 
ATOM   449  C  CA  . VAL A 1 60  ? -32.69607 32.72746 -5.90670  1.000 14.81042 ? 60  VAL A CA  1 
ATOM   450  C  C   . VAL A 1 60  ? -33.09925 31.36251 -5.37049  1.000 13.90336 ? 60  VAL A C   1 
ATOM   451  O  O   . VAL A 1 60  ? -34.26679 31.18259 -5.01589  1.000 13.29569 ? 60  VAL A O   1 
ATOM   452  C  CB  . VAL A 1 60  ? -33.65010 33.11717 -7.05464  1.000 17.58778 ? 60  VAL A CB  1 
ATOM   453  C  CG1 . VAL A 1 60  ? -33.39277 34.55861 -7.50107  1.000 17.62793 ? 60  VAL A CG1 1 
ATOM   454  C  CG2 . VAL A 1 60  ? -33.54442 32.14240 -8.22397  1.000 11.02196 ? 60  VAL A CG2 1 
ATOM   455  N  N   . MET A 1 61  ? -32.18545 30.39084 -5.29177  1.000 13.37162 ? 61  MET A N   1 
ATOM   456  C  CA  . MET A 1 61  ? -32.47386 29.14205 -4.59577  1.000 12.21706 ? 61  MET A CA  1 
ATOM   457  C  C   . MET A 1 61  ? -31.74672 29.03400 -3.26458  1.000 14.14116 ? 61  MET A C   1 
ATOM   458  O  O   . MET A 1 61  ? -31.80859 27.98253 -2.61906  1.000 16.21004 ? 61  MET A O   1 
ATOM   459  C  CB  . MET A 1 61  ? -32.14260 27.94059 -5.48934  1.000 12.55519 ? 61  MET A CB  1 
ATOM   460  C  CG  . MET A 1 61  ? -33.06406 27.86797 -6.72464  1.000 17.72066 ? 61  MET A CG  1 
ATOM   461  S  SD  . MET A 1 61  ? -32.83982 26.39729 -7.74876  1.000 22.75118 ? 61  MET A SD  1 
ATOM   462  C  CE  . MET A 1 61  ? -33.45737 26.95444 -9.35798  1.000 13.55293 ? 61  MET A CE  1 
ATOM   463  N  N   . LYS A 1 62  ? -31.05692 30.08650 -2.84804  1.000 11.04426 ? 62  LYS A N   1 
ATOM   464  C  CA  . LYS A 1 62  ? -30.47092 30.16411 -1.52253  1.000 13.99232 ? 62  LYS A CA  1 
ATOM   465  C  C   . LYS A 1 62  ? -31.57740 30.20735 -0.46766  1.000 11.96193 ? 62  LYS A C   1 
ATOM   466  O  O   . LYS A 1 62  ? -32.70067 30.62708 -0.75388  1.000 13.62380 ? 62  LYS A O   1 
ATOM   467  C  CB  . LYS A 1 62  ? -29.58934 31.41268 -1.42336  1.000 15.78129 ? 62  LYS A CB  1 
ATOM   468  C  CG  . LYS A 1 62  ? -28.11596 31.22157 -1.79408  1.000 19.21155 ? 62  LYS A CG  1 
ATOM   469  C  CD  . LYS A 1 62  ? -27.93560 30.28602 -2.95206  1.000 33.95147 ? 62  LYS A CD  1 
ATOM   470  C  CE  . LYS A 1 62  ? -26.55560 29.63974 -2.93157  1.000 34.26138 ? 62  LYS A CE  1 
ATOM   471  N  NZ  . LYS A 1 62  ? -25.41937 30.59660 -2.93967  1.000 39.68421 ? 62  LYS A NZ  1 
ATOM   472  N  N   . PRO A 1 63  ? -31.27507 29.79078 0.76657   1.000 12.92475 ? 63  PRO A N   1 
ATOM   473  C  CA  . PRO A 1 63  ? -32.32510 29.73270 1.80650   1.000 11.05342 ? 63  PRO A CA  1 
ATOM   474  C  C   . PRO A 1 63  ? -33.09870 31.02417 2.02701   1.000 16.63167 ? 63  PRO A C   1 
ATOM   475  O  O   . PRO A 1 63  ? -34.33380 30.98863 2.13505   1.000 14.26665 ? 63  PRO A O   1 
ATOM   476  C  CB  . PRO A 1 63  ? -31.53254 29.33694 3.06185   1.000 10.50476 ? 63  PRO A CB  1 
ATOM   477  C  CG  . PRO A 1 63  ? -30.38678 28.53304 2.52796   1.000 11.02228 ? 63  PRO A CG  1 
ATOM   478  C  CD  . PRO A 1 63  ? -29.99312 29.24376 1.24494   1.000 13.35560 ? 63  PRO A CD  1 
ATOM   479  N  N   . ILE A 1 64  ? -32.40997 32.16623 2.12233   1.000 14.25020 ? 64  ILE A N   1 
ATOM   480  C  CA  . ILE A 1 64  ? -33.12105 33.40610 2.40395   1.000 13.64194 ? 64  ILE A CA  1 
ATOM   481  C  C   . ILE A 1 64  ? -34.05578 33.76509 1.25420   1.000 16.46720 ? 64  ILE A C   1 
ATOM   482  O  O   . ILE A 1 64  ? -35.07636 34.43047 1.46997   1.000 15.77788 ? 64  ILE A O   1 
ATOM   483  C  CB  . ILE A 1 64  ? -32.13360 34.55105 2.72085   1.000 16.94681 ? 64  ILE A CB  1 
ATOM   484  C  CG1 . ILE A 1 64  ? -32.87202 35.72977 3.37935   1.000 16.04140 ? 64  ILE A CG1 1 
ATOM   485  C  CG2 . ILE A 1 64  ? -31.36985 34.99887 1.45760   1.000 11.62488 ? 64  ILE A CG2 1 
ATOM   486  C  CD1 . ILE A 1 64  ? -31.98068 36.63538 4.24941   1.000 15.81887 ? 64  ILE A CD1 1 
ATOM   487  N  N   . SER A 1 65  ? -33.74874 33.32119 0.02449   1.000 13.40051 ? 65  SER A N   1 
ATOM   488  C  CA  . SER A 1 65  ? -34.62744 33.61400 -1.10584  1.000 17.41648 ? 65  SER A CA  1 
ATOM   489  C  C   . SER A 1 65  ? -35.81846 32.67484 -1.14929  1.000 17.50078 ? 65  SER A C   1 
ATOM   490  O  O   . SER A 1 65  ? -36.87608 33.04532 -1.67002  1.000 17.76445 ? 65  SER A O   1 
ATOM   491  C  CB  . SER A 1 65  ? -33.87029 33.51593 -2.43238  1.000 15.18820 ? 65  SER A CB  1 
ATOM   492  O  OG  . SER A 1 65  ? -32.81904 34.45987 -2.47850  1.000 22.65936 ? 65  SER A OG  1 
ATOM   493  N  N   . ILE A 1 66  ? -35.66293 31.46170 -0.62984  1.000 15.25548 ? 66  ILE A N   1 
ATOM   494  C  CA  . ILE A 1 66  ? -36.73191 30.47760 -0.69986  1.000 14.72831 ? 66  ILE A CA  1 
ATOM   495  C  C   . ILE A 1 66  ? -37.69626 30.61029 0.47594   1.000 12.75172 ? 66  ILE A C   1 
ATOM   496  O  O   . ILE A 1 66  ? -38.90919 30.64864 0.27868   1.000 14.56422 ? 66  ILE A O   1 
ATOM   497  C  CB  . ILE A 1 66  ? -36.13930 29.05985 -0.79167  1.000 12.38585 ? 66  ILE A CB  1 
ATOM   498  C  CG1 . ILE A 1 66  ? -35.38804 28.88778 -2.12024  1.000 14.23753 ? 66  ILE A CG1 1 
ATOM   499  C  CG2 . ILE A 1 66  ? -37.25315 28.01017 -0.63224  1.000 9.97589  ? 66  ILE A CG2 1 
ATOM   500  C  CD1 . ILE A 1 66  ? -36.28661 28.72815 -3.33206  1.000 10.96078 ? 66  ILE A CD1 1 
ATOM   501  N  N   . GLN A 1 67  ? -37.20024 30.67930 1.71210   1.000 11.01991 ? 67  GLN A N   1 
ATOM   502  C  CA  . GLN A 1 67  ? -38.05322 30.80245 2.89902   1.000 13.74010 ? 67  GLN A CA  1 
ATOM   503  C  C   . GLN A 1 67  ? -37.58832 31.97260 3.77319   1.000 14.00960 ? 67  GLN A C   1 
ATOM   504  O  O   . GLN A 1 67  ? -37.07017 31.77635 4.88237   1.000 10.92216 ? 67  GLN A O   1 
ATOM   505  C  CB  . GLN A 1 67  ? -38.07238 29.49331 3.69262   1.000 10.89796 ? 67  GLN A CB  1 
ATOM   506  C  CG  . GLN A 1 67  ? -39.33414 29.33553 4.54985   1.000 12.88632 ? 67  GLN A CG  1 
ATOM   507  C  CD  . GLN A 1 67  ? -39.30652 28.13355 5.49025   1.000 11.74990 ? 67  GLN A CD  1 
ATOM   508  O  OE1 . GLN A 1 67  ? -40.20953 27.96422 6.31066   1.000 14.45221 ? 67  GLN A OE1 1 
ATOM   509  N  NE2 . GLN A 1 67  ? -38.28948 27.27967 5.35605   1.000 12.41829 ? 67  GLN A NE2 1 
ATOM   510  N  N   . PRO A 1 68  ? -37.78715 33.21226 3.31102   1.000 9.86661  ? 68  PRO A N   1 
ATOM   511  C  CA  . PRO A 1 68  ? -37.26785 34.36279 4.07123   1.000 13.87334 ? 68  PRO A CA  1 
ATOM   512  C  C   . PRO A 1 68  ? -37.94512 34.54985 5.41610   1.000 15.76181 ? 68  PRO A C   1 
ATOM   513  O  O   . PRO A 1 68  ? -37.33129 35.11101 6.33374   1.000 17.57435 ? 68  PRO A O   1 
ATOM   514  C  CB  . PRO A 1 68  ? -37.53349 35.55042 3.13437   1.000 14.52426 ? 68  PRO A CB  1 
ATOM   515  C  CG  . PRO A 1 68  ? -38.73096 35.11963 2.32882   1.000 13.97217 ? 68  PRO A CG  1 
ATOM   516  C  CD  . PRO A 1 68  ? -38.56529 33.62987 2.13218   1.000 12.54793 ? 68  PRO A CD  1 
ATOM   517  N  N   . GLU A 1 69  ? -39.19403 34.10884 5.55865   1.000 14.33933 ? 69  GLU A N   1 
ATOM   518  C  CA  . GLU A 1 69  ? -39.85741 33.99451 6.84987   1.000 17.62658 ? 69  GLU A CA  1 
ATOM   519  C  C   . GLU A 1 69  ? -40.39346 32.57703 6.97098   1.000 16.24168 ? 69  GLU A C   1 
ATOM   520  O  O   . GLU A 1 69  ? -40.75620 31.95686 5.96778   1.000 15.67383 ? 69  GLU A O   1 
ATOM   521  C  CB  . GLU A 1 69  ? -41.00501 35.00954 7.00757   1.000 20.36491 ? 69  GLU A CB  1 
ATOM   522  C  CG  . GLU A 1 69  ? -40.67011 36.45338 6.60801   1.000 23.69720 ? 69  GLU A CG  1 
ATOM   523  C  CD  . GLU A 1 69  ? -41.89178 37.37985 6.69433   1.000 34.68703 ? 69  GLU A CD  1 
ATOM   524  O  OE1 . GLU A 1 69  ? -42.58745 37.36744 7.73550   1.000 44.35833 ? 69  GLU A OE1 1 
ATOM   525  O  OE2 . GLU A 1 69  ? -42.16848 38.11385 5.71982   1.000 38.83281 ? 69  GLU A OE2 1 
ATOM   526  N  N   . GLU A 1 70  ? -40.43236 32.05585 8.19547   1.000 14.39792 ? 70  GLU A N   1 
ATOM   527  C  CA  . GLU A 1 70  ? -40.90642 30.68876 8.38001   1.000 17.82742 ? 70  GLU A CA  1 
ATOM   528  C  C   . GLU A 1 70  ? -42.31307 30.52500 7.82181   1.000 18.46748 ? 70  GLU A C   1 
ATOM   529  O  O   . GLU A 1 70  ? -43.21858 31.28870 8.16157   1.000 16.03094 ? 70  GLU A O   1 
ATOM   530  C  CB  . GLU A 1 70  ? -40.89474 30.30252 9.85117   1.000 15.92743 ? 70  GLU A CB  1 
ATOM   531  C  CG  . GLU A 1 70  ? -41.22900 28.85809 10.05534  1.000 13.20994 ? 70  GLU A CG  1 
ATOM   532  C  CD  . GLU A 1 70  ? -41.03521 28.40330 11.48718  1.000 19.08423 ? 70  GLU A CD  1 
ATOM   533  O  OE1 . GLU A 1 70  ? -40.87173 29.26818 12.38305  1.000 18.61496 ? 70  GLU A OE1 1 
ATOM   534  O  OE2 . GLU A 1 70  ? -41.04688 27.17169 11.70981  1.000 18.15135 ? 70  GLU A OE2 1 
ATOM   535  N  N   . GLY A 1 71  ? -42.48797 29.52473 6.95453   1.000 13.94090 ? 71  GLY A N   1 
ATOM   536  C  CA  . GLY A 1 71  ? -43.76948 29.25408 6.34266   1.000 14.31166 ? 71  GLY A CA  1 
ATOM   537  C  C   . GLY A 1 71  ? -44.09152 30.08646 5.11687   1.000 14.49437 ? 71  GLY A C   1 
ATOM   538  O  O   . GLY A 1 71  ? -45.12619 29.84655 4.48588   1.000 14.60296 ? 71  GLY A O   1 
ATOM   539  N  N   . LYS A 1 72  ? -43.25010 31.05999 4.76219   1.000 13.71918 ? 72  LYS A N   1 
ATOM   540  C  CA  . LYS A 1 72  ? -43.42609 31.85049 3.54484   1.000 13.67157 ? 72  LYS A CA  1 
ATOM   541  C  C   . LYS A 1 72  ? -42.39995 31.37081 2.52949   1.000 15.26261 ? 72  LYS A C   1 
ATOM   542  O  O   . LYS A 1 72  ? -41.22364 31.73650 2.61204   1.000 14.38983 ? 72  LYS A O   1 
ATOM   543  C  CB  . LYS A 1 72  ? -43.25663 33.34082 3.82492   1.000 15.37327 ? 72  LYS A CB  1 
ATOM   544  C  CG  . LYS A 1 72  ? -44.22959 33.91583 4.82071   1.000 28.00467 ? 72  LYS A CG  1 
ATOM   545  C  CD  . LYS A 1 72  ? -44.14577 35.43308 4.82222   1.000 36.92743 ? 72  LYS A CD  1 
ATOM   546  C  CE  . LYS A 1 72  ? -45.09637 36.04455 5.83790   1.000 36.10239 ? 72  LYS A CE  1 
ATOM   547  N  NZ  . LYS A 1 72  ? -46.50030 35.92668 5.38067   1.000 41.53855 ? 72  LYS A NZ  1 
ATOM   548  N  N   . PHE A 1 73  ? -42.84097 30.54581 1.57732   1.000 15.75484 ? 73  PHE A N   1 
ATOM   549  C  CA  . PHE A 1 73  ? -41.97718 30.02905 0.51990   1.000 15.89785 ? 73  PHE A CA  1 
ATOM   550  C  C   . PHE A 1 73  ? -42.18713 30.81987 -0.76023  1.000 17.95849 ? 73  PHE A C   1 
ATOM   551  O  O   . PHE A 1 73  ? -43.32615 31.01924 -1.19364  1.000 19.63652 ? 73  PHE A O   1 
ATOM   552  C  CB  . PHE A 1 73  ? -42.23655 28.54350 0.26170   1.000 14.23548 ? 73  PHE A CB  1 
ATOM   553  C  CG  . PHE A 1 73  ? -41.87832 27.67457 1.42412   1.000 15.55973 ? 73  PHE A CG  1 
ATOM   554  C  CD1 . PHE A 1 73  ? -42.77939 27.49398 2.46458   1.000 14.07539 ? 73  PHE A CD1 1 
ATOM   555  C  CD2 . PHE A 1 73  ? -40.61998 27.08727 1.51158   1.000 10.06220 ? 73  PHE A CD2 1 
ATOM   556  C  CE1 . PHE A 1 73  ? -42.44318 26.71588 3.55426   1.000 14.25696 ? 73  PHE A CE1 1 
ATOM   557  C  CE2 . PHE A 1 73  ? -40.27799 26.30464 2.60271   1.000 10.84063 ? 73  PHE A CE2 1 
ATOM   558  C  CZ  . PHE A 1 73  ? -41.18856 26.11073 3.61941   1.000 12.56427 ? 73  PHE A CZ  1 
ATOM   559  N  N   . ASN A 1 74  ? -41.08898 31.26456 -1.36272  1.000 17.09915 ? 74  ASN A N   1 
ATOM   560  C  CA  . ASN A 1 74  ? -41.12115 31.98362 -2.63114  1.000 18.56562 ? 74  ASN A CA  1 
ATOM   561  C  C   . ASN A 1 74  ? -40.42419 31.10502 -3.67070  1.000 20.81698 ? 74  ASN A C   1 
ATOM   562  O  O   . ASN A 1 74  ? -39.20797 31.16296 -3.84138  1.000 18.73854 ? 74  ASN A O   1 
ATOM   563  C  CB  . ASN A 1 74  ? -40.46364 33.36205 -2.49897  1.000 23.75364 ? 74  ASN A CB  1 
ATOM   564  C  CG  . ASN A 1 74  ? -41.27248 34.32305 -1.60115  1.000 37.13360 ? 74  ASN A CG  1 
ATOM   565  O  OD1 . ASN A 1 74  ? -42.50618 34.24850 -1.53945  1.000 41.47256 ? 74  ASN A OD1 1 
ATOM   566  N  ND2 . ASN A 1 74  ? -40.57409 35.23889 -0.91693  1.000 39.75441 ? 74  ASN A ND2 1 
ATOM   567  N  N   . PHE A 1 75  ? -41.20029 30.28331 -4.36714  1.000 12.18891 ? 75  PHE A N   1 
ATOM   568  C  CA  . PHE A 1 75  ? -40.64917 29.47827 -5.44744  1.000 14.61534 ? 75  PHE A CA  1 
ATOM   569  C  C   . PHE A 1 75  ? -40.77776 30.13026 -6.82172  1.000 15.33717 ? 75  PHE A C   1 
ATOM   570  O  O   . PHE A 1 75  ? -40.33259 29.53622 -7.80346  1.000 15.66069 ? 75  PHE A O   1 
ATOM   571  C  CB  . PHE A 1 75  ? -41.32692 28.11079 -5.49488  1.000 9.44526  ? 75  PHE A CB  1 
ATOM   572  C  CG  . PHE A 1 75  ? -41.07613 27.25737 -4.29163  1.000 11.82159 ? 75  PHE A CG  1 
ATOM   573  C  CD1 . PHE A 1 75  ? -39.81409 26.77594 -4.01538  1.000 12.15770 ? 75  PHE A CD1 1 
ATOM   574  C  CD2 . PHE A 1 75  ? -42.12214 26.91885 -3.43940  1.000 11.08747 ? 75  PHE A CD2 1 
ATOM   575  C  CE1 . PHE A 1 75  ? -39.59249 25.96048 -2.90293  1.000 12.36002 ? 75  PHE A CE1 1 
ATOM   576  C  CE2 . PHE A 1 75  ? -41.91731 26.11065 -2.35079  1.000 10.53644 ? 75  PHE A CE2 1 
ATOM   577  C  CZ  . PHE A 1 75  ? -40.64587 25.63420 -2.06947  1.000 14.67197 ? 75  PHE A CZ  1 
ATOM   578  N  N   . GLU A 1 76  ? -41.36554 31.32547 -6.92777  1.000 14.90510 ? 76  GLU A N   1 
ATOM   579  C  CA  . GLU A 1 76  ? -41.66353 31.87985 -8.24991  1.000 18.11044 ? 76  GLU A CA  1 
ATOM   580  C  C   . GLU A 1 76  ? -40.40066 32.03399 -9.09659  1.000 18.22953 ? 76  GLU A C   1 
ATOM   581  O  O   . GLU A 1 76  ? -40.39961 31.70902 -10.28804 1.000 15.80607 ? 76  GLU A O   1 
ATOM   582  C  CB  . GLU A 1 76  ? -42.38061 33.22608 -8.10797  1.000 25.04118 ? 76  GLU A CB  1 
ATOM   583  C  CG  . GLU A 1 76  ? -42.81908 33.84767 -9.41750  1.000 32.13606 ? 76  GLU A CG  1 
ATOM   584  C  CD  . GLU A 1 76  ? -43.30641 35.28288 -9.25105  1.000 46.28218 ? 76  GLU A CD  1 
ATOM   585  O  OE1 . GLU A 1 76  ? -44.54254 35.52156 -9.36078  1.000 38.78174 ? 76  GLU A OE1 1 
ATOM   586  O  OE2 . GLU A 1 76  ? -42.44590 36.16921 -9.01199  1.000 44.21178 ? 76  GLU A OE2 1 
ATOM   587  N  N   . GLN A 1 77  ? -39.30492 32.49501 -8.49082  1.000 19.00943 ? 77  GLN A N   1 
ATOM   588  C  CA  . GLN A 1 77  ? -38.08373 32.73216 -9.25696  1.000 20.77700 ? 77  GLN A CA  1 
ATOM   589  C  C   . GLN A 1 77  ? -37.38357 31.42228 -9.60579  1.000 17.53765 ? 77  GLN A C   1 
ATOM   590  O  O   . GLN A 1 77  ? -36.98561 31.20764 -10.75565 1.000 14.85334 ? 77  GLN A O   1 
ATOM   591  C  CB  . GLN A 1 77  ? -37.16501 33.66143 -8.46934  1.000 22.48178 ? 77  GLN A CB  1 
ATOM   592  C  CG  . GLN A 1 77  ? -37.76454 35.05724 -8.30298  1.000 25.90083 ? 77  GLN A CG  1 
ATOM   593  C  CD  . GLN A 1 77  ? -37.46768 35.93718 -9.50291  1.000 37.64015 ? 77  GLN A CD  1 
ATOM   594  O  OE1 . GLN A 1 77  ? -38.01227 35.73620 -10.59439 1.000 40.74206 ? 77  GLN A OE1 1 
ATOM   595  N  NE2 . GLN A 1 77  ? -36.57241 36.90605 -9.31443  1.000 38.15406 ? 77  GLN A NE2 1 
ATOM   596  N  N   . ALA A 1 78  ? -37.24733 30.52370 -8.62678  1.000 13.48779 ? 78  ALA A N   1 
ATOM   597  C  CA  . ALA A 1 78  ? -36.68927 29.20396 -8.89831  1.000 16.69407 ? 78  ALA A CA  1 
ATOM   598  C  C   . ALA A 1 78  ? -37.49341 28.48067 -9.97475  1.000 16.33798 ? 78  ALA A C   1 
ATOM   599  O  O   . ALA A 1 78  ? -36.92318 27.87531 -10.88839 1.000 13.65782 ? 78  ALA A O   1 
ATOM   600  C  CB  . ALA A 1 78  ? -36.65017 28.38285 -7.60586  1.000 13.61528 ? 78  ALA A CB  1 
ATOM   601  N  N   . ASP A 1 79  ? -38.82898 28.52765 -9.87201  1.000 14.87076 ? 79  ASP A N   1 
ATOM   602  C  CA  . ASP A 1 79  ? -39.69042 27.91847 -10.88134 1.000 13.29827 ? 79  ASP A CA  1 
ATOM   603  C  C   . ASP A 1 79  ? -39.32517 28.38531 -12.29188 1.000 15.65581 ? 79  ASP A C   1 
ATOM   604  O  O   . ASP A 1 79  ? -39.33078 27.59358 -13.24043 1.000 13.80946 ? 79  ASP A O   1 
ATOM   605  C  CB  . ASP A 1 79  ? -41.15570 28.25925 -10.59645 1.000 14.54802 ? 79  ASP A CB  1 
ATOM   606  C  CG  . ASP A 1 79  ? -41.74278 27.47914 -9.42772  1.000 19.24347 ? 79  ASP A CG  1 
ATOM   607  O  OD1 . ASP A 1 79  ? -41.11201 26.51317 -8.93179  1.000 15.94686 ? 79  ASP A OD1 1 
ATOM   608  O  OD2 . ASP A 1 79  ? -42.86950 27.83976 -9.01158  1.000 15.38517 ? 79  ASP A OD2 1 
ATOM   609  N  N   . ARG A 1 80  ? -39.01732 29.67582 -12.45160 1.000 14.42329 ? 80  ARG A N   1 
ATOM   610  C  CA  . ARG A 1 80  ? -38.74480 30.20479 -13.78496 1.000 14.92152 ? 80  ARG A CA  1 
ATOM   611  C  C   . ARG A 1 80  ? -37.48253 29.59120 -14.37848 1.000 15.32968 ? 80  ARG A C   1 
ATOM   612  O  O   . ARG A 1 80  ? -37.44598 29.24604 -15.56630 1.000 13.93524 ? 80  ARG A O   1 
ATOM   613  C  CB  . ARG A 1 80  ? -38.64910 31.72506 -13.71375 1.000 15.32612 ? 80  ARG A CB  1 
ATOM   614  C  CG  . ARG A 1 80  ? -39.99218 32.36442 -13.86590 1.000 22.31768 ? 80  ARG A CG  1 
ATOM   615  C  CD  . ARG A 1 80  ? -40.04670 33.76258 -13.33311 1.000 32.74017 ? 80  ARG A CD  1 
ATOM   616  N  NE  . ARG A 1 80  ? -41.44790 34.14814 -13.18040 1.000 42.45909 ? 80  ARG A NE  1 
ATOM   617  C  CZ  . ARG A 1 80  ? -41.85985 35.35906 -12.82974 1.000 41.77638 ? 80  ARG A CZ  1 
ATOM   618  N  NH1 . ARG A 1 80  ? -40.97136 36.31556 -12.59832 1.000 49.62232 ? 80  ARG A NH1 1 
ATOM   619  N  NH2 . ARG A 1 80  ? -43.15778 35.61233 -12.71377 1.000 45.39707 ? 80  ARG A NH2 1 
ATOM   620  N  N   . ILE A 1 81  ? -36.45200 29.41539 -13.55436 1.000 13.96146 ? 81  ILE A N   1 
ATOM   621  C  CA  . ILE A 1 81  ? -35.23841 28.74188 -13.99518 1.000 13.89006 ? 81  ILE A CA  1 
ATOM   622  C  C   . ILE A 1 81  ? -35.51209 27.27203 -14.30769 1.000 15.29216 ? 81  ILE A C   1 
ATOM   623  O  O   . ILE A 1 81  ? -34.97043 26.71905 -15.27459 1.000 12.99804 ? 81  ILE A O   1 
ATOM   624  C  CB  . ILE A 1 81  ? -34.14697 28.91625 -12.92271 1.000 14.28025 ? 81  ILE A CB  1 
ATOM   625  C  CG1 . ILE A 1 81  ? -33.70746 30.38280 -12.88167 1.000 13.64889 ? 81  ILE A CG1 1 
ATOM   626  C  CG2 . ILE A 1 81  ? -32.95747 27.99215 -13.17994 1.000 9.47888  ? 81  ILE A CG2 1 
ATOM   627  C  CD1 . ILE A 1 81  ? -32.88008 30.72768 -11.65649 1.000 16.17193 ? 81  ILE A CD1 1 
ATOM   628  N  N   . VAL A 1 82  ? -36.33980 26.60976 -13.49256 1.000 13.82419 ? 82  VAL A N   1 
ATOM   629  C  CA  . VAL A 1 82  ? -36.65554 25.19966 -13.73515 1.000 10.63821 ? 82  VAL A CA  1 
ATOM   630  C  C   . VAL A 1 82  ? -37.41565 25.03938 -15.04446 1.000 13.87273 ? 82  VAL A C   1 
ATOM   631  O  O   . VAL A 1 82  ? -37.13419 24.12585 -15.83397 1.000 13.51165 ? 82  VAL A O   1 
ATOM   632  C  CB  . VAL A 1 82  ? -37.44743 24.61087 -12.54968 1.000 13.15726 ? 82  VAL A CB  1 
ATOM   633  C  CG1 . VAL A 1 82  ? -38.01830 23.24849 -12.89931 1.000 8.51354  ? 82  VAL A CG1 1 
ATOM   634  C  CG2 . VAL A 1 82  ? -36.55788 24.50736 -11.31731 1.000 13.87011 ? 82  VAL A CG2 1 
ATOM   635  N  N   . LYS A 1 83  ? -38.39126 25.92458 -15.29215 1.000 12.97634 ? 83  LYS A N   1 
ATOM   636  C  CA  . LYS A 1 83  ? -39.17990 25.85474 -16.51581 1.000 16.22179 ? 83  LYS A CA  1 
ATOM   637  C  C   . LYS A 1 83  ? -38.30517 26.06672 -17.74789 1.000 13.72968 ? 83  LYS A C   1 
ATOM   638  O  O   . LYS A 1 83  ? -38.42477 25.33644 -18.73653 1.000 14.83585 ? 83  LYS A O   1 
ATOM   639  C  CB  . LYS A 1 83  ? -40.29757 26.89502 -16.47426 1.000 14.79776 ? 83  LYS A CB  1 
ATOM   640  C  CG  . LYS A 1 83  ? -41.39645 26.62546 -17.50466 1.000 30.66569 ? 83  LYS A CG  1 
ATOM   641  C  CD  . LYS A 1 83  ? -41.93058 27.89415 -18.17743 1.000 33.37672 ? 83  LYS A CD  1 
ATOM   642  C  CE  . LYS A 1 83  ? -42.09928 29.03119 -17.17354 1.000 42.39745 ? 83  LYS A CE  1 
ATOM   643  N  NZ  . LYS A 1 83  ? -41.98293 30.40898 -17.76613 1.000 42.69766 ? 83  LYS A NZ  1 
ATOM   644  N  N   . PHE A 1 84  ? -37.42283 27.06928 -17.70618 1.000 11.53876 ? 84  PHE A N   1 
ATOM   645  C  CA  . PHE A 1 84  ? -36.50591 27.30863 -18.81500 1.000 13.83522 ? 84  PHE A CA  1 
ATOM   646  C  C   . PHE A 1 84  ? -35.64147 26.08621 -19.07924 1.000 11.01718 ? 84  PHE A C   1 
ATOM   647  O  O   . PHE A 1 84  ? -35.43419 25.69764 -20.23335 1.000 11.52411 ? 84  PHE A O   1 
ATOM   648  C  CB  . PHE A 1 84  ? -35.62667 28.53096 -18.52335 1.000 12.20793 ? 84  PHE A CB  1 
ATOM   649  C  CG  . PHE A 1 84  ? -34.72360 28.90408 -19.66104 1.000 12.14284 ? 84  PHE A CG  1 
ATOM   650  C  CD1 . PHE A 1 84  ? -35.17823 29.72643 -20.68704 1.000 13.51084 ? 84  PHE A CD1 1 
ATOM   651  C  CD2 . PHE A 1 84  ? -33.41396 28.43437 -19.71301 1.000 10.56753 ? 84  PHE A CD2 1 
ATOM   652  C  CE1 . PHE A 1 84  ? -34.34484 30.08440 -21.74890 1.000 11.88687 ? 84  PHE A CE1 1 
ATOM   653  C  CE2 . PHE A 1 84  ? -32.57287 28.79055 -20.76860 1.000 11.99508 ? 84  PHE A CE2 1 
ATOM   654  C  CZ  . PHE A 1 84  ? -33.04559 29.61817 -21.79306 1.000 10.08885 ? 84  PHE A CZ  1 
ATOM   655  N  N   . ALA A 1 85  ? -35.11054 25.47647 -18.01922 1.000 14.08396 ? 85  ALA A N   1 
ATOM   656  C  CA  . ALA A 1 85  ? -34.24427 24.32110 -18.20645 1.000 13.27667 ? 85  ALA A CA  1 
ATOM   657  C  C   . ALA A 1 85  ? -35.00474 23.18372 -18.86587 1.000 13.61576 ? 85  ALA A C   1 
ATOM   658  O  O   . ALA A 1 85  ? -34.53507 22.59468 -19.84281 1.000 13.90763 ? 85  ALA A O   1 
ATOM   659  C  CB  . ALA A 1 85  ? -33.66584 23.87258 -16.86654 1.000 10.72317 ? 85  ALA A CB  1 
ATOM   660  N  N   . LYS A 1 86  ? -36.18593 22.85614 -18.33564 1.000 14.88797 ? 86  LYS A N   1 
ATOM   661  C  CA  . LYS A 1 86  ? -36.96852 21.76372 -18.90778 1.000 19.01489 ? 86  LYS A CA  1 
ATOM   662  C  C   . LYS A 1 86  ? -37.29151 22.02727 -20.37232 1.000 17.70685 ? 86  LYS A C   1 
ATOM   663  O  O   . LYS A 1 86  ? -37.16431 21.12989 -21.21047 1.000 19.43899 ? 86  LYS A O   1 
ATOM   664  C  CB  . LYS A 1 86  ? -38.25024 21.54769 -18.10194 1.000 18.78463 ? 86  LYS A CB  1 
ATOM   665  C  CG  . LYS A 1 86  ? -38.00470 20.94371 -16.71845 1.000 23.31174 ? 86  LYS A CG  1 
ATOM   666  C  CD  . LYS A 1 86  ? -39.24064 21.02975 -15.84071 1.000 26.03168 ? 86  LYS A CD  1 
ATOM   667  C  CE  . LYS A 1 86  ? -40.08231 19.77974 -15.94413 1.000 29.28842 ? 86  LYS A CE  1 
ATOM   668  N  NZ  . LYS A 1 86  ? -40.38208 19.39581 -17.34522 1.000 47.37450 ? 86  LYS A NZ  1 
ATOM   669  N  N   . ALA A 1 87  ? -37.67649 23.26160 -20.70581 1.000 15.55360 ? 87  ALA A N   1 
ATOM   670  C  CA  . ALA A 1 87  ? -37.96496 23.59612 -22.09752 1.000 14.50908 ? 87  ALA A CA  1 
ATOM   671  C  C   . ALA A 1 87  ? -36.74741 23.47654 -23.00697 1.000 16.83591 ? 87  ALA A C   1 
ATOM   672  O  O   . ALA A 1 87  ? -36.90848 23.35334 -24.22343 1.000 11.58949 ? 87  ALA A O   1 
ATOM   673  C  CB  . ALA A 1 87  ? -38.52871 25.01315 -22.19245 1.000 15.92467 ? 87  ALA A CB  1 
ATOM   674  N  N   . ASN A 1 88  ? -35.52656 23.51997 -22.47184 1.000 15.67453 ? 88  ASN A N   1 
ATOM   675  C  CA  . ASN A 1 88  ? -34.35453 23.46609 -23.34156 1.000 13.55564 ? 88  ASN A CA  1 
ATOM   676  C  C   . ASN A 1 88  ? -33.46398 22.26913 -23.05031 1.000 12.11770 ? 88  ASN A C   1 
ATOM   677  O  O   . ASN A 1 88  ? -32.29844 22.25343 -23.46532 1.000 17.20481 ? 88  ASN A O   1 
ATOM   678  C  CB  . ASN A 1 88  ? -33.56824 24.77401 -23.24503 1.000 13.95637 ? 88  ASN A CB  1 
ATOM   679  C  CG  . ASN A 1 88  ? -34.38673 25.96416 -23.72708 1.000 15.69950 ? 88  ASN A CG  1 
ATOM   680  O  OD1 . ASN A 1 88  ? -34.43178 26.24627 -24.92170 1.000 18.91581 ? 88  ASN A OD1 1 
ATOM   681  N  ND2 . ASN A 1 88  ? -35.05341 26.65442 -22.79871 1.000 14.28080 ? 88  ASN A ND2 1 
ATOM   682  N  N   . GLY A 1 89  ? -33.99176 21.26212 -22.35751 1.000 17.17743 ? 89  GLY A N   1 
ATOM   683  C  CA  . GLY A 1 89  ? -33.25098 20.02788 -22.12429 1.000 15.11246 ? 89  GLY A CA  1 
ATOM   684  C  C   . GLY A 1 89  ? -32.02033 20.18949 -21.26145 1.000 13.74645 ? 89  GLY A C   1 
ATOM   685  O  O   . GLY A 1 89  ? -31.04992 19.46051 -21.44988 1.000 17.83139 ? 89  GLY A O   1 
ATOM   686  N  N   . MET A 1 90  ? -32.02583 21.12793 -20.31994 1.000 11.67242 ? 90  MET A N   1 
ATOM   687  C  CA  . MET A 1 90  ? -30.86003 21.38304 -19.47940 1.000 12.06663 ? 90  MET A CA  1 
ATOM   688  C  C   . MET A 1 90  ? -30.96667 20.62359 -18.16198 1.000 15.08138 ? 90  MET A C   1 
ATOM   689  O  O   . MET A 1 90  ? -32.04307 20.56138 -17.55897 1.000 13.36390 ? 90  MET A O   1 
ATOM   690  C  CB  . MET A 1 90  ? -30.71669 22.88298 -19.19353 1.000 8.81749  ? 90  MET A CB  1 
ATOM   691  C  CG  . MET A 1 90  ? -30.65990 23.75114 -20.45633 1.000 10.89540 ? 90  MET A CG  1 
ATOM   692  S  SD  . MET A 1 90  ? -30.67700 25.50896 -20.06761 1.000 10.16869 ? 90  MET A SD  1 
ATOM   693  C  CE  . MET A 1 90  ? -28.91811 25.84392 -19.92474 1.000 6.55783  ? 90  MET A CE  1 
ATOM   694  N  N   . ASP A 1 91  ? -29.84950 20.04308 -17.72229 1.000 10.39640 ? 91  ASP A N   1 
ATOM   695  C  CA  . ASP A 1 91  ? -29.75307 19.60350 -16.33698 1.000 11.99256 ? 91  ASP A CA  1 
ATOM   696  C  C   . ASP A 1 91  ? -29.89732 20.80938 -15.41152 1.000 14.08840 ? 91  ASP A C   1 
ATOM   697  O  O   . ASP A 1 91  ? -29.58427 21.94270 -15.78224 1.000 12.89165 ? 91  ASP A O   1 
ATOM   698  C  CB  . ASP A 1 91  ? -28.40755 18.91733 -16.07133 1.000 12.73070 ? 91  ASP A CB  1 
ATOM   699  C  CG  . ASP A 1 91  ? -28.31110 17.52453 -16.69532 1.000 14.44655 ? 91  ASP A CG  1 
ATOM   700  O  OD1 . ASP A 1 91  ? -29.34933 16.99087 -17.13644 1.000 15.26238 ? 91  ASP A OD1 1 
ATOM   701  O  OD2 . ASP A 1 91  ? -27.18633 16.97737 -16.75034 1.000 15.87885 ? 91  ASP A OD2 1 
ATOM   702  N  N   . ILE A 1 92  ? -30.35962 20.56213 -14.19027 1.000 10.41518 ? 92  ILE A N   1 
ATOM   703  C  CA  . ILE A 1 92  ? -30.50578 21.60728 -13.18393 1.000 10.35139 ? 92  ILE A CA  1 
ATOM   704  C  C   . ILE A 1 92  ? -29.71293 21.20181 -11.95442 1.000 10.29000 ? 92  ILE A C   1 
ATOM   705  O  O   . ILE A 1 92  ? -29.76104 20.03932 -11.53638 1.000 9.65988  ? 92  ILE A O   1 
ATOM   706  C  CB  . ILE A 1 92  ? -31.98322 21.83960 -12.79807 1.000 10.99741 ? 92  ILE A CB  1 
ATOM   707  C  CG1 . ILE A 1 92  ? -32.87890 21.93311 -14.03444 1.000 11.60777 ? 92  ILE A CG1 1 
ATOM   708  C  CG2 . ILE A 1 92  ? -32.12658 23.08370 -11.92185 1.000 11.01339 ? 92  ILE A CG2 1 
ATOM   709  C  CD1 . ILE A 1 92  ? -34.38075 21.98596 -13.69011 1.000 8.97526  ? 92  ILE A CD1 1 
ATOM   710  N  N   . ARG A 1 93  ? -28.99370 22.15816 -11.37209 1.000 9.58046  ? 93  ARG A N   1 
ATOM   711  C  CA  . ARG A 1 93  ? -28.41690 22.00099 -10.04304 1.000 9.72015  ? 93  ARG A CA  1 
ATOM   712  C  C   . ARG A 1 93  ? -29.14058 22.93145 -9.08190  1.000 10.39167 ? 93  ARG A C   1 
ATOM   713  O  O   . ARG A 1 93  ? -29.47087 24.06707 -9.44171  1.000 10.71051 ? 93  ARG A O   1 
ATOM   714  C  CB  . ARG A 1 93  ? -26.90466 22.29926 -10.04163 1.000 11.79710 ? 93  ARG A CB  1 
ATOM   715  C  CG  . ARG A 1 93  ? -26.11895 21.49863 -11.10289 1.000 11.33151 ? 93  ARG A CG  1 
ATOM   716  C  CD  . ARG A 1 93  ? -24.60226 21.63564 -10.94073 1.000 12.62232 ? 93  ARG A CD  1 
ATOM   717  N  NE  . ARG A 1 93  ? -24.14712 20.87824 -9.78531  1.000 17.16333 ? 93  ARG A NE  1 
ATOM   718  C  CZ  . ARG A 1 93  ? -23.92866 21.39238 -8.57879  1.000 16.38528 ? 93  ARG A CZ  1 
ATOM   719  N  NH1 . ARG A 1 93  ? -24.10268 22.69089 -8.35912  1.000 14.30727 ? 93  ARG A NH1 1 
ATOM   720  N  NH2 . ARG A 1 93  ? -23.52633 20.59445 -7.59097  1.000 15.62183 ? 93  ARG A NH2 1 
ATOM   721  N  N   . PHE A 1 94  ? -29.40438 22.44487 -7.86747  1.000 8.83175  ? 94  PHE A N   1 
ATOM   722  C  CA  . PHE A 1 94  ? -29.97161 23.27133 -6.81357  1.000 7.99379  ? 94  PHE A CA  1 
ATOM   723  C  C   . PHE A 1 94  ? -28.86333 23.77545 -5.89505  1.000 11.93535 ? 94  PHE A C   1 
ATOM   724  O  O   . PHE A 1 94  ? -28.19492 22.98365 -5.22104  1.000 11.54014 ? 94  PHE A O   1 
ATOM   725  C  CB  . PHE A 1 94  ? -31.01993 22.51630 -6.00307  1.000 8.99241  ? 94  PHE A CB  1 
ATOM   726  C  CG  . PHE A 1 94  ? -31.76399 23.39675 -5.04702  1.000 11.46237 ? 94  PHE A CG  1 
ATOM   727  C  CD1 . PHE A 1 94  ? -31.22187 23.71784 -3.80764  1.000 8.43464  ? 94  PHE A CD1 1 
ATOM   728  C  CD2 . PHE A 1 94  ? -32.98278 23.95155 -5.40672  1.000 11.32927 ? 94  PHE A CD2 1 
ATOM   729  C  CE1 . PHE A 1 94  ? -31.89761 24.55567 -2.92741  1.000 10.03481 ? 94  PHE A CE1 1 
ATOM   730  C  CE2 . PHE A 1 94  ? -33.66898 24.79385 -4.52748  1.000 11.07716 ? 94  PHE A CE2 1 
ATOM   731  C  CZ  . PHE A 1 94  ? -33.12344 25.09085 -3.28690  1.000 11.63763 ? 94  PHE A CZ  1 
ATOM   732  N  N   . HIS A 1 95  ? -28.72334 25.09780 -5.82496  1.000 10.77446 ? 95  HIS A N   1 
ATOM   733  C  CA  . HIS A 1 95  ? -27.72087 25.78221 -5.01110  1.000 11.20327 ? 95  HIS A CA  1 
ATOM   734  C  C   . HIS A 1 95  ? -28.49671 26.78008 -4.15242  1.000 11.88420 ? 95  HIS A C   1 
ATOM   735  O  O   . HIS A 1 95  ? -28.94845 27.79865 -4.68245  1.000 13.39000 ? 95  HIS A O   1 
ATOM   736  C  CB  . HIS A 1 95  ? -26.70691 26.47472 -5.93469  1.000 13.19495 ? 95  HIS A CB  1 
ATOM   737  C  CG  . HIS A 1 95  ? -25.42177 26.85868 -5.27498  1.000 15.68199 ? 95  HIS A CG  1 
ATOM   738  N  ND1 . HIS A 1 95  ? -24.42092 25.94447 -5.00285  1.000 8.00547  ? 95  HIS A ND1 1 
ATOM   739  C  CD2 . HIS A 1 95  ? -24.96813 28.06236 -4.84664  1.000 13.32914 ? 95  HIS A CD2 1 
ATOM   740  C  CE1 . HIS A 1 95  ? -23.41870 26.56305 -4.40851  1.000 14.16319 ? 95  HIS A CE1 1 
ATOM   741  N  NE2 . HIS A 1 95  ? -23.71643 27.85132 -4.32015  1.000 21.74800 ? 95  HIS A NE2 1 
ATOM   742  N  N   . THR A 1 96  ? -28.70216 26.52988 -2.84838  1.000 13.85312 ? 96  THR A N   1 
ATOM   743  C  CA  . THR A 1 96  ? -28.16038 25.45427 -2.00415  1.000 10.84615 ? 96  THR A CA  1 
ATOM   744  C  C   . THR A 1 96  ? -29.12644 25.24722 -0.83388  1.000 11.43370 ? 96  THR A C   1 
ATOM   745  O  O   . THR A 1 96  ? -29.74068 26.21071 -0.37787  1.000 11.47174 ? 96  THR A O   1 
ATOM   746  C  CB  . THR A 1 96  ? -26.77261 25.82177 -1.42071  1.000 11.74703 ? 96  THR A CB  1 
ATOM   747  O  OG1 . THR A 1 96  ? -25.85554 26.07847 -2.48366  1.000 17.07149 ? 96  THR A OG1 1 
ATOM   748  C  CG2 . THR A 1 96  ? -26.22529 24.72498 -0.53398  1.000 9.98818  ? 96  THR A CG2 1 
ATOM   749  N  N   . LEU A 1 97  ? -29.22338 24.02652 -0.30018  1.000 10.82561 ? 97  LEU A N   1 
ATOM   750  C  CA  . LEU A 1 97  ? -30.19578 23.76964 0.76162   1.000 9.64684  ? 97  LEU A CA  1 
ATOM   751  C  C   . LEU A 1 97  ? -29.77060 24.39308 2.09224   1.000 14.90201 ? 97  LEU A C   1 
ATOM   752  O  O   . LEU A 1 97  ? -30.60267 24.98698 2.78648   1.000 13.60861 ? 97  LEU A O   1 
ATOM   753  C  CB  . LEU A 1 97  ? -30.41886 22.26078 0.91900   1.000 10.02397 ? 97  LEU A CB  1 
ATOM   754  C  CG  . LEU A 1 97  ? -31.21549 21.57061 -0.19774  1.000 11.93331 ? 97  LEU A CG  1 
ATOM   755  C  CD1 . LEU A 1 97  ? -31.17095 20.05588 -0.03206  1.000 11.20461 ? 97  LEU A CD1 1 
ATOM   756  C  CD2 . LEU A 1 97  ? -32.64860 22.07517 -0.27026  1.000 8.25358  ? 97  LEU A CD2 1 
ATOM   757  N  N   . VAL A 1 98  ? -28.49300 24.26106 2.47764   1.000 11.03452 ? 98  VAL A N   1 
ATOM   758  C  CA  . VAL A 1 98  ? -27.99178 24.75833 3.76054   1.000 14.08612 ? 98  VAL A CA  1 
ATOM   759  C  C   . VAL A 1 98  ? -26.70747 25.53891 3.53183   1.000 15.69911 ? 98  VAL A C   1 
ATOM   760  O  O   . VAL A 1 98  ? -25.77822 25.02956 2.89598   1.000 14.43263 ? 98  VAL A O   1 
ATOM   761  C  CB  . VAL A 1 98  ? -27.71000 23.62571 4.76709   1.000 18.20747 ? 98  VAL A CB  1 
ATOM   762  C  CG1 . VAL A 1 98  ? -27.37605 24.21490 6.13889   1.000 17.56931 ? 98  VAL A CG1 1 
ATOM   763  C  CG2 . VAL A 1 98  ? -28.87251 22.68592 4.85046   1.000 13.01228 ? 98  VAL A CG2 1 
ATOM   764  N  N   . TRP A 1 99  ? -26.63557 26.74573 4.10033   1.000 16.24780 ? 99  TRP A N   1 
ATOM   765  C  CA  . TRP A 1 99  ? -25.46241 27.60703 3.98904   1.000 16.23959 ? 99  TRP A CA  1 
ATOM   766  C  C   . TRP A 1 99  ? -25.45929 28.58888 5.15645   1.000 15.76713 ? 99  TRP A C   1 
ATOM   767  O  O   . TRP A 1 99  ? -26.51645 28.94698 5.67827   1.000 19.80625 ? 99  TRP A O   1 
ATOM   768  C  CB  . TRP A 1 99  ? -25.46936 28.35694 2.65807   1.000 11.93401 ? 99  TRP A CB  1 
ATOM   769  C  CG  . TRP A 1 99  ? -24.17744 28.97150 2.25942   1.000 17.64160 ? 99  TRP A CG  1 
ATOM   770  C  CD1 . TRP A 1 99  ? -22.91665 28.53810 2.57358   1.000 17.02627 ? 99  TRP A CD1 1 
ATOM   771  C  CD2 . TRP A 1 99  ? -24.01032 30.14325 1.45078   1.000 20.57595 ? 99  TRP A CD2 1 
ATOM   772  N  NE1 . TRP A 1 99  ? -21.97934 29.37153 2.00778   1.000 16.63746 ? 99  TRP A NE1 1 
ATOM   773  C  CE2 . TRP A 1 99  ? -22.62480 30.36193 1.31331   1.000 17.85102 ? 99  TRP A CE2 1 
ATOM   774  C  CE3 . TRP A 1 99  ? -24.90255 31.02922 0.82937   1.000 25.60736 ? 99  TRP A CE3 1 
ATOM   775  C  CZ2 . TRP A 1 99  ? -22.10723 31.43493 0.58873   1.000 25.54151 ? 99  TRP A CZ2 1 
ATOM   776  C  CZ3 . TRP A 1 99  ? -24.38836 32.09846 0.11400   1.000 28.85841 ? 99  TRP A CZ3 1 
ATOM   777  C  CH2 . TRP A 1 99  ? -22.99995 32.28503 -0.00885  1.000 29.39480 ? 99  TRP A CH2 1 
ATOM   778  N  N   . HIS A 1 100 ? -24.26270 29.03541 5.55050   1.000 15.29583 ? 100 HIS A N   1 
ATOM   779  C  CA  . HIS A 1 100 ? -24.15008 29.97789 6.65823   1.000 16.47496 ? 100 HIS A CA  1 
ATOM   780  C  C   . HIS A 1 100 ? -24.34694 31.42515 6.22826   1.000 18.26947 ? 100 HIS A C   1 
ATOM   781  O  O   . HIS A 1 100 ? -24.40988 32.30725 7.08826   1.000 20.13975 ? 100 HIS A O   1 
ATOM   782  C  CB  . HIS A 1 100 ? -22.79129 29.82425 7.34646   1.000 17.35054 ? 100 HIS A CB  1 
ATOM   783  C  CG  . HIS A 1 100 ? -21.64087 30.30112 6.51720   1.000 17.81753 ? 100 HIS A CG  1 
ATOM   784  N  ND1 . HIS A 1 100 ? -21.07559 29.53460 5.51904   1.000 15.06221 ? 100 HIS A ND1 1 
ATOM   785  C  CD2 . HIS A 1 100 ? -20.96789 31.47711 6.51892   1.000 16.48676 ? 100 HIS A CD2 1 
ATOM   786  C  CE1 . HIS A 1 100 ? -20.09188 30.21255 4.95350   1.000 15.24743 ? 100 HIS A CE1 1 
ATOM   787  N  NE2 . HIS A 1 100 ? -20.00402 31.39180 5.54494   1.000 18.04931 ? 100 HIS A NE2 1 
ATOM   788  N  N   . SER A 1 101 ? -24.43933 31.68517 4.92826   1.000 20.01647 ? 101 SER A N   1 
ATOM   789  C  CA  . SER A 1 101 ? -24.71080 33.00021 4.37033   1.000 22.74688 ? 101 SER A CA  1 
ATOM   790  C  C   . SER A 1 101 ? -26.03773 32.96012 3.62525   1.000 19.76697 ? 101 SER A C   1 
ATOM   791  O  O   . SER A 1 101 ? -26.54033 31.88654 3.29060   1.000 21.21955 ? 101 SER A O   1 
ATOM   792  C  CB  . SER A 1 101 ? -23.58654 33.43825 3.41340   1.000 19.41729 ? 101 SER A CB  1 
ATOM   793  O  OG  . SER A 1 101 ? -22.47263 33.90907 4.14867   1.000 34.14725 ? 101 SER A OG  1 
ATOM   794  N  N   . GLN A 1 102 ? -26.59332 34.13836 3.34466   1.000 24.39605 ? 102 GLN A N   1 
ATOM   795  C  CA  . GLN A 1 102 ? -27.90788 34.26055 2.70714   1.000 25.59934 ? 102 GLN A CA  1 
ATOM   796  C  C   . GLN A 1 102 ? -28.89475 33.25925 3.32954   1.000 27.20589 ? 102 GLN A C   1 
ATOM   797  O  O   . GLN A 1 102 ? -29.48676 32.39932 2.65833   1.000 11.99494 ? 102 GLN A O   1 
ATOM   798  C  CB  . GLN A 1 102 ? -27.79823 34.08279 1.18389   1.000 29.62802 ? 102 GLN A CB  1 
ATOM   799  C  CG  . GLN A 1 102 ? -27.12577 35.25525 0.44499   1.000 28.58230 ? 102 GLN A CG  1 
ATOM   800  C  CD  . GLN A 1 102 ? -27.01762 35.01580 -1.06389  1.000 45.18150 ? 102 GLN A CD  1 
ATOM   801  O  OE1 . GLN A 1 102 ? -25.95922 34.61844 -1.57232  1.000 42.63999 ? 102 GLN A OE1 1 
ATOM   802  N  NE2 . GLN A 1 102 ? -28.11222 35.26334 -1.78663  1.000 40.54594 ? 102 GLN A NE2 1 
ATOM   803  N  N   . VAL A 1 103 ? -29.01951 33.37277 4.65381   1.000 18.31428 ? 103 VAL A N   1 
ATOM   804  C  CA  . VAL A 1 103 ? -29.78361 32.42746 5.46043   1.000 23.99736 ? 103 VAL A CA  1 
ATOM   805  C  C   . VAL A 1 103 ? -30.58963 33.22243 6.48285   1.000 23.48163 ? 103 VAL A C   1 
ATOM   806  O  O   . VAL A 1 103 ? -30.02442 34.00230 7.26545   1.000 22.12386 ? 103 VAL A O   1 
ATOM   807  C  CB  . VAL A 1 103 ? -28.86195 31.37376 6.11048   1.000 27.98862 ? 103 VAL A CB  1 
ATOM   808  C  CG1 . VAL A 1 103 ? -27.80170 32.01190 7.02692   1.000 22.67205 ? 103 VAL A CG1 1 
ATOM   809  C  CG2 . VAL A 1 103 ? -29.67327 30.31834 6.85654   1.000 22.65185 ? 103 VAL A CG2 1 
ATOM   810  N  N   . PRO A 1 104 ? -31.90947 33.07292 6.49459   1.000 18.00509 ? 104 PRO A N   1 
ATOM   811  C  CA  . PRO A 1 104 ? -32.74229 33.94335 7.33523   1.000 22.95853 ? 104 PRO A CA  1 
ATOM   812  C  C   . PRO A 1 104 ? -32.50708 33.70127 8.82121   1.000 20.48944 ? 104 PRO A C   1 
ATOM   813  O  O   . PRO A 1 104 ? -32.35893 32.56253 9.27036   1.000 18.56652 ? 104 PRO A O   1 
ATOM   814  C  CB  . PRO A 1 104 ? -34.17368 33.57378 6.92023   1.000 19.38177 ? 104 PRO A CB  1 
ATOM   815  C  CG  . PRO A 1 104 ? -34.07075 32.24106 6.26857   1.000 17.72293 ? 104 PRO A CG  1 
ATOM   816  C  CD  . PRO A 1 104 ? -32.70006 32.12925 5.68505   1.000 19.10824 ? 104 PRO A CD  1 
ATOM   817  N  N   . GLN A 1 105 ? -32.47655 34.79351 9.59236   1.000 23.21397 ? 105 GLN A N   1 
ATOM   818  C  CA  . GLN A 1 105 ? -32.13086 34.65976 11.00103  1.000 21.95518 ? 105 GLN A CA  1 
ATOM   819  C  C   . GLN A 1 105 ? -33.23703 33.99821 11.82194  1.000 25.12717 ? 105 GLN A C   1 
ATOM   820  O  O   . GLN A 1 105 ? -32.95233 33.50482 12.92103  1.000 21.27274 ? 105 GLN A O   1 
ATOM   821  C  CB  . GLN A 1 105 ? -31.76640 36.02662 11.59537  1.000 27.49312 ? 105 GLN A CB  1 
ATOM   822  C  CG  . GLN A 1 105 ? -30.27638 36.14134 12.03626  1.000 40.38864 ? 105 GLN A CG  1 
ATOM   823  C  CD  . GLN A 1 105 ? -29.86380 35.15582 13.16614  1.000 46.60562 ? 105 GLN A CD  1 
ATOM   824  O  OE1 . GLN A 1 105 ? -30.67563 34.78769 14.03172  1.000 39.49147 ? 105 GLN A OE1 1 
ATOM   825  N  NE2 . GLN A 1 105 ? -28.58870 34.74108 13.15568  1.000 33.77926 ? 105 GLN A NE2 1 
ATOM   826  N  N   . TRP A 1 106 ? -34.48186 33.94176 11.31785  1.000 20.80119 ? 106 TRP A N   1 
ATOM   827  C  CA  . TRP A 1 106 ? -35.52635 33.26981 12.08975  1.000 20.58520 ? 106 TRP A CA  1 
ATOM   828  C  C   . TRP A 1 106 ? -35.16480 31.82468 12.40179  1.000 18.29342 ? 106 TRP A C   1 
ATOM   829  O  O   . TRP A 1 106 ? -35.65610 31.28264 13.39297  1.000 19.11813 ? 106 TRP A O   1 
ATOM   830  C  CB  . TRP A 1 106 ? -36.88747 33.32404 11.37211  1.000 21.28993 ? 106 TRP A CB  1 
ATOM   831  C  CG  . TRP A 1 106 ? -36.96594 32.56923 10.07075  1.000 17.08350 ? 106 TRP A CG  1 
ATOM   832  C  CD1 . TRP A 1 106 ? -36.86732 33.10134 8.81521   1.000 17.17223 ? 106 TRP A CD1 1 
ATOM   833  C  CD2 . TRP A 1 106 ? -37.18722 31.16233 9.89383   1.000 15.69477 ? 106 TRP A CD2 1 
ATOM   834  N  NE1 . TRP A 1 106 ? -37.00432 32.11506 7.87043   1.000 17.31341 ? 106 TRP A NE1 1 
ATOM   835  C  CE2 . TRP A 1 106 ? -37.20229 30.91509 8.50455   1.000 16.30691 ? 106 TRP A CE2 1 
ATOM   836  C  CE3 . TRP A 1 106 ? -37.38242 30.08946 10.77306  1.000 18.39225 ? 106 TRP A CE3 1 
ATOM   837  C  CZ2 . TRP A 1 106 ? -37.38156 29.63203 7.97066   1.000 12.87041 ? 106 TRP A CZ2 1 
ATOM   838  C  CZ3 . TRP A 1 106 ? -37.56175 28.81907 10.24694  1.000 17.18354 ? 106 TRP A CZ3 1 
ATOM   839  C  CH2 . TRP A 1 106 ? -37.55697 28.60082 8.85392   1.000 15.72481 ? 106 TRP A CH2 1 
ATOM   840  N  N   . PHE A 1 107 ? -34.30249 31.19868 11.59198  1.000 19.60227 ? 107 PHE A N   1 
ATOM   841  C  CA  . PHE A 1 107 ? -33.88961 29.82066 11.85289  1.000 18.49096 ? 107 PHE A CA  1 
ATOM   842  C  C   . PHE A 1 107 ? -33.30454 29.66627 13.24994  1.000 17.85136 ? 107 PHE A C   1 
ATOM   843  O  O   . PHE A 1 107 ? -33.51431 28.64351 13.91123  1.000 20.04476 ? 107 PHE A O   1 
ATOM   844  C  CB  . PHE A 1 107 ? -32.84288 29.38091 10.82610  1.000 18.42424 ? 107 PHE A CB  1 
ATOM   845  C  CG  . PHE A 1 107 ? -33.40917 28.69762 9.61173   1.000 19.78480 ? 107 PHE A CG  1 
ATOM   846  C  CD1 . PHE A 1 107 ? -34.02764 27.45678 9.71504   1.000 17.19006 ? 107 PHE A CD1 1 
ATOM   847  C  CD2 . PHE A 1 107 ? -33.30170 29.28922 8.35992   1.000 17.80510 ? 107 PHE A CD2 1 
ATOM   848  C  CE1 . PHE A 1 107 ? -34.53475 26.81580 8.58718   1.000 16.73825 ? 107 PHE A CE1 1 
ATOM   849  C  CE2 . PHE A 1 107 ? -33.79898 28.65657 7.22803   1.000 17.40304 ? 107 PHE A CE2 1 
ATOM   850  C  CZ  . PHE A 1 107 ? -34.41663 27.42077 7.33719   1.000 14.49962 ? 107 PHE A CZ  1 
ATOM   851  N  N   . PHE A 1 108 ? -32.53809 30.65803 13.70022  1.000 17.59874 ? 108 PHE A N   1 
ATOM   852  C  CA  . PHE A 1 108 ? -31.68075 30.51934 14.87033  1.000 21.70789 ? 108 PHE A CA  1 
ATOM   853  C  C   . PHE A 1 108 ? -32.22630 31.24701 16.10201  1.000 23.92851 ? 108 PHE A C   1 
ATOM   854  O  O   . PHE A 1 108 ? -31.45991 31.54877 17.02285  1.000 25.90963 ? 108 PHE A O   1 
ATOM   855  C  CB  . PHE A 1 108 ? -30.26808 31.00672 14.52994  1.000 18.31510 ? 108 PHE A CB  1 
ATOM   856  C  CG  . PHE A 1 108 ? -29.73587 30.44097 13.23456  1.000 19.19393 ? 108 PHE A CG  1 
ATOM   857  C  CD1 . PHE A 1 108 ? -29.52757 29.07772 13.09666  1.000 15.84886 ? 108 PHE A CD1 1 
ATOM   858  C  CD2 . PHE A 1 108 ? -29.47241 31.26876 12.15050  1.000 20.08861 ? 108 PHE A CD2 1 
ATOM   859  C  CE1 . PHE A 1 108 ? -29.05968 28.54981 11.90320  1.000 19.62276 ? 108 PHE A CE1 1 
ATOM   860  C  CE2 . PHE A 1 108 ? -29.00297 30.75002 10.94947  1.000 22.06893 ? 108 PHE A CE2 1 
ATOM   861  C  CZ  . PHE A 1 108 ? -28.79292 29.38672 10.82481  1.000 19.40049 ? 108 PHE A CZ  1 
ATOM   862  N  N   . LEU A 1 109 ? -33.53089 31.52713 16.13881  1.000 23.55881 ? 109 LEU A N   1 
ATOM   863  C  CA  . LEU A 1 109 ? -34.19414 32.11825 17.29755  1.000 24.13607 ? 109 LEU A CA  1 
ATOM   864  C  C   . LEU A 1 109 ? -34.95792 31.04990 18.06770  1.000 25.27357 ? 109 LEU A C   1 
ATOM   865  O  O   . LEU A 1 109 ? -35.61016 30.18809 17.46469  1.000 23.53352 ? 109 LEU A O   1 
ATOM   866  C  CB  . LEU A 1 109 ? -35.16137 33.21988 16.86923  1.000 23.19775 ? 109 LEU A CB  1 
ATOM   867  C  CG  . LEU A 1 109 ? -34.52759 34.40013 16.14449  1.000 25.64814 ? 109 LEU A CG  1 
ATOM   868  C  CD1 . LEU A 1 109 ? -35.57171 35.46630 15.93471  1.000 20.92806 ? 109 LEU A CD1 1 
ATOM   869  C  CD2 . LEU A 1 109 ? -33.32993 34.93909 16.93741  1.000 24.78377 ? 109 LEU A CD2 1 
ATOM   870  N  N   . ASP A 1 110 ? -34.87755 31.10794 19.40166  1.000 25.91849 ? 110 ASP A N   1 
ATOM   871  C  CA  . ASP A 1 110 ? -35.62208 30.18228 20.24845  1.000 27.40634 ? 110 ASP A CA  1 
ATOM   872  C  C   . ASP A 1 110 ? -37.08650 30.61302 20.34163  1.000 31.42528 ? 110 ASP A C   1 
ATOM   873  O  O   . ASP A 1 110 ? -37.50999 31.61011 19.74653  1.000 29.35744 ? 110 ASP A O   1 
ATOM   874  C  CB  . ASP A 1 110 ? -34.98936 30.08092 21.63921  1.000 35.40648 ? 110 ASP A CB  1 
ATOM   875  C  CG  . ASP A 1 110 ? -34.97918 31.41990 22.39709  1.000 34.53440 ? 110 ASP A CG  1 
ATOM   876  O  OD1 . ASP A 1 110 ? -35.70118 32.36415 22.00543  1.000 28.12893 ? 110 ASP A OD1 1 
ATOM   877  O  OD2 . ASP A 1 110 ? -34.23520 31.52412 23.39786  1.000 33.33818 ? 110 ASP A OD2 1 
ATOM   878  N  N   . LYS A 1 111 ? -37.86669 29.87378 21.13518  1.000 33.36313 ? 111 LYS A N   1 
ATOM   879  C  CA  . LYS A 1 111 ? -39.30501 30.10899 21.16415  1.000 33.13386 ? 111 LYS A CA  1 
ATOM   880  C  C   . LYS A 1 111 ? -39.65732 31.45923 21.76464  1.000 36.39737 ? 111 LYS A C   1 
ATOM   881  O  O   . LYS A 1 111 ? -40.74472 31.97763 21.49670  1.000 38.80833 ? 111 LYS A O   1 
ATOM   882  C  CB  . LYS A 1 111 ? -40.00483 28.97745 21.91213  1.000 37.83776 ? 111 LYS A CB  1 
ATOM   883  C  CG  . LYS A 1 111 ? -39.70407 27.60736 21.31055  1.000 40.43178 ? 111 LYS A CG  1 
ATOM   884  C  CD  . LYS A 1 111 ? -40.96096 26.77867 21.06539  1.000 45.77086 ? 111 LYS A CD  1 
ATOM   885  C  CE  . LYS A 1 111 ? -40.79735 25.86771 19.84515  1.000 38.68575 ? 111 LYS A CE  1 
ATOM   886  N  NZ  . LYS A 1 111 ? -41.22400 24.45759 20.09739  1.000 47.05836 ? 111 LYS A NZ  1 
ATOM   887  N  N   . GLU A 1 112 ? -38.75243 32.06123 22.52463  1.000 34.90969 ? 112 GLU A N   1 
ATOM   888  C  CA  . GLU A 1 112 ? -38.97722 33.38368 23.08406  1.000 35.37259 ? 112 GLU A CA  1 
ATOM   889  C  C   . GLU A 1 112 ? -38.36550 34.49214 22.23428  1.000 33.44022 ? 112 GLU A C   1 
ATOM   890  O  O   . GLU A 1 112 ? -38.34039 35.64851 22.66957  1.000 34.62807 ? 112 GLU A O   1 
ATOM   891  C  CB  . GLU A 1 112 ? -38.43397 33.44236 24.51880  1.000 40.28275 ? 112 GLU A CB  1 
ATOM   892  C  CG  . GLU A 1 112 ? -39.45238 33.05874 25.60953  1.000 43.57085 ? 112 GLU A CG  1 
ATOM   893  C  CD  . GLU A 1 112 ? -40.23070 31.77919 25.30417  1.000 55.40420 ? 112 GLU A CD  1 
ATOM   894  O  OE1 . GLU A 1 112 ? -41.45077 31.86566 25.01076  1.000 56.78451 ? 112 GLU A OE1 1 
ATOM   895  O  OE2 . GLU A 1 112 ? -39.62388 30.68560 25.37746  1.000 55.53464 ? 112 GLU A OE2 1 
ATOM   896  N  N   . GLY A 1 113 ? -37.86874 34.16893 21.04064  1.000 30.73505 ? 113 GLY A N   1 
ATOM   897  C  CA  . GLY A 1 113 ? -37.36557 35.16720 20.11495  1.000 24.93025 ? 113 GLY A CA  1 
ATOM   898  C  C   . GLY A 1 113 ? -35.91944 35.57081 20.30187  1.000 28.65764 ? 113 GLY A C   1 
ATOM   899  O  O   . GLY A 1 113 ? -35.46897 36.51402 19.63901  1.000 29.95553 ? 113 GLY A O   1 
ATOM   900  N  N   . LYS A 1 114 ? -35.16610 34.88693 21.19161  1.000 25.61985 ? 114 LYS A N   1 
ATOM   901  C  CA  . LYS A 1 114 ? -33.78665 35.24637 21.48493  1.000 27.64048 ? 114 LYS A CA  1 
ATOM   902  C  C   . LYS A 1 114 ? -32.81549 34.35504 20.71525  1.000 29.36882 ? 114 LYS A C   1 
ATOM   903  O  O   . LYS A 1 114 ? -33.14476 33.21520 20.37006  1.000 27.10648 ? 114 LYS A O   1 
ATOM   904  C  CB  . LYS A 1 114 ? -33.50352 35.12357 22.98811  1.000 32.97494 ? 114 LYS A CB  1 
ATOM   905  C  CG  . LYS A 1 114 ? -34.44707 35.93238 23.88662  1.000 43.54154 ? 114 LYS A CG  1 
ATOM   906  C  CD  . LYS A 1 114 ? -33.82948 37.25567 24.32953  1.000 49.15337 ? 114 LYS A CD  1 
ATOM   907  C  CE  . LYS A 1 114 ? -34.78580 38.02849 25.23960  1.000 52.19592 ? 114 LYS A CE  1 
ATOM   908  N  NZ  . LYS A 1 114 ? -35.88896 38.70011 24.46939  1.000 50.60689 ? 114 LYS A NZ  1 
ATOM   909  N  N   . PRO A 1 115 ? -31.60611 34.83849 20.44234  1.000 24.41919 ? 115 PRO A N   1 
ATOM   910  C  CA  . PRO A 1 115 ? -30.63375 34.01061 19.71598  1.000 27.32749 ? 115 PRO A CA  1 
ATOM   911  C  C   . PRO A 1 115 ? -30.34111 32.71566 20.45757  1.000 31.20620 ? 115 PRO A C   1 
ATOM   912  O  O   . PRO A 1 115 ? -30.02173 32.72126 21.64680  1.000 35.52697 ? 115 PRO A O   1 
ATOM   913  C  CB  . PRO A 1 115 ? -29.39428 34.90883 19.63298  1.000 28.85391 ? 115 PRO A CB  1 
ATOM   914  C  CG  . PRO A 1 115 ? -29.94485 36.31946 19.74828  1.000 28.42225 ? 115 PRO A CG  1 
ATOM   915  C  CD  . PRO A 1 115 ? -31.09331 36.19418 20.70792  1.000 29.19583 ? 115 PRO A CD  1 
ATOM   916  N  N   . MET A 1 116 ? -30.45501 31.59688 19.73458  1.000 30.70878 ? 116 MET A N   1 
ATOM   917  C  CA  . MET A 1 116 ? -30.15017 30.29159 20.31219  1.000 26.56811 ? 116 MET A CA  1 
ATOM   918  C  C   . MET A 1 116 ? -28.69010 30.18338 20.73941  1.000 32.66578 ? 116 MET A C   1 
ATOM   919  O  O   . MET A 1 116 ? -28.37547 29.43870 21.68042  1.000 29.20550 ? 116 MET A O   1 
ATOM   920  C  CB  . MET A 1 116 ? -30.47201 29.18474 19.30676  1.000 19.57913 ? 116 MET A CB  1 
ATOM   921  C  CG  . MET A 1 116 ? -31.93116 29.03835 18.93573  1.000 26.57022 ? 116 MET A CG  1 
ATOM   922  S  SD  . MET A 1 116 ? -32.14509 27.67702 17.75736  1.000 23.99403 ? 116 MET A SD  1 
ATOM   923  C  CE  . MET A 1 116 ? -33.91237 27.44620 17.75976  1.000 22.35368 ? 116 MET A CE  1 
ATOM   924  N  N   . VAL A 1 117 ? -27.78115 30.88352 20.04634  1.000 26.16787 ? 117 VAL A N   1 
ATOM   925  C  CA  . VAL A 1 117 ? -26.36235 30.76771 20.38065  1.000 27.30671 ? 117 VAL A CA  1 
ATOM   926  C  C   . VAL A 1 117 ? -26.08698 31.28234 21.78756  1.000 31.34302 ? 117 VAL A C   1 
ATOM   927  O  O   . VAL A 1 117 ? -25.14074 30.82817 22.44078  1.000 34.90197 ? 117 VAL A O   1 
ATOM   928  C  CB  . VAL A 1 117 ? -25.47905 31.49694 19.34651  1.000 26.18191 ? 117 VAL A CB  1 
ATOM   929  C  CG1 . VAL A 1 117 ? -25.50852 30.78334 18.00429  1.000 26.14411 ? 117 VAL A CG1 1 
ATOM   930  C  CG2 . VAL A 1 117 ? -25.88927 32.95273 19.21557  1.000 25.95569 ? 117 VAL A CG2 1 
ATOM   931  N  N   . ASN A 1 118 ? -26.90685 32.21760 22.28392  1.000 31.33562 ? 118 ASN A N   1 
ATOM   932  C  CA  . ASN A 1 118 ? -26.73115 32.79786 23.61378  1.000 33.34046 ? 118 ASN A CA  1 
ATOM   933  C  C   . ASN A 1 118 ? -27.15350 31.87044 24.75601  1.000 35.02947 ? 118 ASN A C   1 
ATOM   934  O  O   . ASN A 1 118 ? -26.81132 32.14372 25.91149  1.000 45.27869 ? 118 ASN A O   1 
ATOM   935  C  CB  . ASN A 1 118 ? -27.52538 34.10656 23.73610  1.000 27.64123 ? 118 ASN A CB  1 
ATOM   936  C  CG  . ASN A 1 118 ? -27.03257 35.19024 22.79758  1.000 28.43513 ? 118 ASN A CG  1 
ATOM   937  O  OD1 . ASN A 1 118 ? -27.73550 36.16650 22.54033  1.000 31.83634 ? 118 ASN A OD1 1 
ATOM   938  N  ND2 . ASN A 1 118 ? -25.82245 35.02767 22.28413  1.000 33.62546 ? 118 ASN A ND2 1 
ATOM   939  N  N   . GLU A 1 119 ? -27.88395 30.79687 24.48345  1.000 32.88108 ? 119 GLU A N   1 
ATOM   940  C  CA  . GLU A 1 119 ? -28.42776 29.97730 25.55963  1.000 35.58907 ? 119 GLU A CA  1 
ATOM   941  C  C   . GLU A 1 119 ? -27.32353 29.23145 26.30532  1.000 36.57496 ? 119 GLU A C   1 
ATOM   942  O  O   . GLU A 1 119 ? -26.43932 28.63128 25.69463  1.000 38.55248 ? 119 GLU A O   1 
ATOM   943  C  CB  . GLU A 1 119 ? -29.44252 28.98856 24.99031  1.000 31.90595 ? 119 GLU A CB  1 
ATOM   944  C  CG  . GLU A 1 119 ? -30.09912 28.09307 26.01536  1.000 31.42581 ? 119 GLU A CG  1 
ATOM   945  C  CD  . GLU A 1 119 ? -30.83566 28.88493 27.07948  1.000 40.00284 ? 119 GLU A CD  1 
ATOM   946  O  OE1 . GLU A 1 119 ? -31.56406 29.84109 26.72659  1.000 34.66679 ? 119 GLU A OE1 1 
ATOM   947  O  OE2 . GLU A 1 119 ? -30.68149 28.55118 28.27325  1.000 42.98385 ? 119 GLU A OE2 1 
ATOM   948  N  N   . THR A 1 120 ? -27.38910 29.25581 27.64171  1.000 41.48545 ? 120 THR A N   1 
ATOM   949  C  CA  . THR A 1 120 ? -26.39451 28.59383 28.48108  1.000 34.76889 ? 120 THR A CA  1 
ATOM   950  C  C   . THR A 1 120 ? -26.89172 27.31662 29.14707  1.000 39.27756 ? 120 THR A C   1 
ATOM   951  O  O   . THR A 1 120 ? -26.06633 26.48478 29.53622  1.000 40.20238 ? 120 THR A O   1 
ATOM   952  C  CB  . THR A 1 120 ? -25.88917 29.55126 29.57470  1.000 42.67943 ? 120 THR A CB  1 
ATOM   953  O  OG1 . THR A 1 120 ? -26.95941 29.85746 30.47747  1.000 42.08397 ? 120 THR A OG1 1 
ATOM   954  C  CG2 . THR A 1 120 ? -25.37372 30.85357 28.96035  1.000 38.76006 ? 120 THR A CG2 1 
ATOM   955  N  N   . ASP A 1 121 ? -28.19898 27.14105 29.29121  1.000 37.91779 ? 121 ASP A N   1 
ATOM   956  C  CA  . ASP A 1 121 ? -28.75762 25.94018 29.91358  1.000 37.76074 ? 121 ASP A CA  1 
ATOM   957  C  C   . ASP A 1 121 ? -28.64300 24.75030 28.96425  1.000 36.68880 ? 121 ASP A C   1 
ATOM   958  O  O   . ASP A 1 121 ? -29.18950 24.80232 27.85657  1.000 38.95959 ? 121 ASP A O   1 
ATOM   959  C  CB  . ASP A 1 121 ? -30.22004 26.20958 30.28725  1.000 39.89852 ? 121 ASP A CB  1 
ATOM   960  C  CG  . ASP A 1 121 ? -30.91422 25.01369 30.92823  1.000 36.81622 ? 121 ASP A CG  1 
ATOM   961  O  OD1 . ASP A 1 121 ? -30.35650 23.89776 30.97440  1.000 43.61906 ? 121 ASP A OD1 1 
ATOM   962  O  OD2 . ASP A 1 121 ? -32.05446 25.19989 31.39178  1.000 51.14932 ? 121 ASP A OD2 1 
ATOM   963  N  N   . PRO A 1 122 ? -27.97065 23.66319 29.35087  1.000 37.67875 ? 122 PRO A N   1 
ATOM   964  C  CA  . PRO A 1 122 ? -27.85548 22.51481 28.43504  1.000 39.58922 ? 122 PRO A CA  1 
ATOM   965  C  C   . PRO A 1 122 ? -29.18402 21.87563 28.05676  1.000 38.73242 ? 122 PRO A C   1 
ATOM   966  O  O   . PRO A 1 122 ? -29.31127 21.38056 26.92935  1.000 39.79261 ? 122 PRO A O   1 
ATOM   967  C  CB  . PRO A 1 122 ? -26.95059 21.53587 29.20365  1.000 34.99868 ? 122 PRO A CB  1 
ATOM   968  C  CG  . PRO A 1 122 ? -26.88735 22.05118 30.60418  1.000 35.53610 ? 122 PRO A CG  1 
ATOM   969  C  CD  . PRO A 1 122 ? -27.08523 23.52626 30.51759  1.000 39.79090 ? 122 PRO A CD  1 
ATOM   970  N  N   . VAL A 1 123 ? -30.17373 21.85605 28.95201  1.000 36.92751 ? 123 VAL A N   1 
ATOM   971  C  CA  . VAL A 1 123 ? -31.47982 21.31349 28.58240  1.000 36.74322 ? 123 VAL A CA  1 
ATOM   972  C  C   . VAL A 1 123 ? -32.13639 22.19151 27.52358  1.000 36.30983 ? 123 VAL A C   1 
ATOM   973  O  O   . VAL A 1 123 ? -32.79405 21.69408 26.60118  1.000 30.50550 ? 123 VAL A O   1 
ATOM   974  C  CB  . VAL A 1 123 ? -32.38426 21.16202 29.82335  1.000 42.33228 ? 123 VAL A CB  1 
ATOM   975  C  CG1 . VAL A 1 123 ? -33.77757 20.68890 29.41235  1.000 35.14748 ? 123 VAL A CG1 1 
ATOM   976  C  CG2 . VAL A 1 123 ? -31.77719 20.18925 30.82132  1.000 37.42844 ? 123 VAL A CG2 1 
ATOM   977  N  N   . LYS A 1 124 ? -31.97511 23.51103 27.64499  1.000 36.98313 ? 124 LYS A N   1 
ATOM   978  C  CA  . LYS A 1 124 ? -32.54463 24.42047 26.65946  1.000 34.95998 ? 124 LYS A CA  1 
ATOM   979  C  C   . LYS A 1 124 ? -31.74039 24.39223 25.36408  1.000 38.92675 ? 124 LYS A C   1 
ATOM   980  O  O   . LYS A 1 124 ? -32.30739 24.51839 24.27127  1.000 37.88747 ? 124 LYS A O   1 
ATOM   981  C  CB  . LYS A 1 124 ? -32.60759 25.83771 27.22909  1.000 35.92151 ? 124 LYS A CB  1 
ATOM   982  C  CG  . LYS A 1 124 ? -33.85812 26.12357 28.05951  1.000 39.24352 ? 124 LYS A CG  1 
ATOM   983  C  CD  . LYS A 1 124 ? -33.69178 27.39188 28.90903  1.000 46.71811 ? 124 LYS A CD  1 
ATOM   984  C  CE  . LYS A 1 124 ? -34.94283 27.70150 29.73747  1.000 47.56816 ? 124 LYS A CE  1 
ATOM   985  N  NZ  . LYS A 1 124 ? -36.16233 27.85140 28.87916  1.000 55.59979 ? 124 LYS A NZ  1 
ATOM   986  N  N   . ARG A 1 125 ? -30.41789 24.22399 25.46526  1.000 31.97370 ? 125 ARG A N   1 
ATOM   987  C  CA  . ARG A 1 125 ? -29.60092 24.11400 24.26380  1.000 30.64356 ? 125 ARG A CA  1 
ATOM   988  C  C   . ARG A 1 125 ? -29.99020 22.88621 23.46088  1.000 33.26660 ? 125 ARG A C   1 
ATOM   989  O  O   . ARG A 1 125 ? -30.03208 22.93129 22.22468  1.000 30.04318 ? 125 ARG A O   1 
ATOM   990  C  CB  . ARG A 1 125 ? -28.11639 24.07310 24.62542  1.000 27.51529 ? 125 ARG A CB  1 
ATOM   991  C  CG  . ARG A 1 125 ? -27.55915 25.42952 25.03279  1.000 33.90038 ? 125 ARG A CG  1 
ATOM   992  C  CD  . ARG A 1 125 ? -26.05080 25.41202 25.10046  1.000 31.37332 ? 125 ARG A CD  1 
ATOM   993  N  NE  . ARG A 1 125 ? -25.46331 25.17846 23.78537  1.000 37.01279 ? 125 ARG A NE  1 
ATOM   994  C  CZ  . ARG A 1 125 ? -25.24116 26.13526 22.89242  1.000 35.00499 ? 125 ARG A CZ  1 
ATOM   995  N  NH1 . ARG A 1 125 ? -25.55318 27.39558 23.17446  1.000 28.41376 ? 125 ARG A NH1 1 
ATOM   996  N  NH2 . ARG A 1 125 ? -24.69625 25.83231 21.72059  1.000 37.18801 ? 125 ARG A NH2 1 
ATOM   997  N  N   . GLU A 1 126 ? -30.30085 21.78366 24.14370  1.000 28.65000 ? 126 GLU A N   1 
ATOM   998  C  CA  . GLU A 1 126 ? -30.69799 20.58754 23.41570  1.000 29.18842 ? 126 GLU A CA  1 
ATOM   999  C  C   . GLU A 1 126 ? -32.06126 20.77435 22.76445  1.000 32.87869 ? 126 GLU A C   1 
ATOM   1000 O  O   . GLU A 1 126 ? -32.27407 20.33944 21.62556  1.000 29.70767 ? 126 GLU A O   1 
ATOM   1001 C  CB  . GLU A 1 126 ? -30.69111 19.37663 24.34068  1.000 27.98355 ? 126 GLU A CB  1 
ATOM   1002 C  CG  . GLU A 1 126 ? -31.23716 18.11558 23.70065  1.000 28.91738 ? 126 GLU A CG  1 
ATOM   1003 C  CD  . GLU A 1 126 ? -30.34776 17.56547 22.59002  1.000 32.54264 ? 126 GLU A CD  1 
ATOM   1004 O  OE1 . GLU A 1 126 ? -29.17399 17.99518 22.46396  1.000 30.96214 ? 126 GLU A OE1 1 
ATOM   1005 O  OE2 . GLU A 1 126 ? -30.82587 16.68393 21.84499  1.000 34.40465 ? 126 GLU A OE2 1 
ATOM   1006 N  N   . GLN A 1 127 ? -32.99214 21.42912 23.46486  1.000 29.73983 ? 127 GLN A N   1 
ATOM   1007 C  CA  . GLN A 1 127 ? -34.27516 21.76737 22.85335  1.000 34.97609 ? 127 GLN A CA  1 
ATOM   1008 C  C   . GLN A 1 127 ? -34.08163 22.64743 21.62567  1.000 28.09231 ? 127 GLN A C   1 
ATOM   1009 O  O   . GLN A 1 127 ? -34.79256 22.49925 20.62492  1.000 30.54251 ? 127 GLN A O   1 
ATOM   1010 C  CB  . GLN A 1 127 ? -35.18379 22.47201 23.86601  1.000 31.02489 ? 127 GLN A CB  1 
ATOM   1011 C  CG  . GLN A 1 127 ? -35.69884 21.57560 24.98753  1.000 35.73263 ? 127 GLN A CG  1 
ATOM   1012 C  CD  . GLN A 1 127 ? -36.28705 22.36515 26.15475  1.000 40.06033 ? 127 GLN A CD  1 
ATOM   1013 O  OE1 . GLN A 1 127 ? -36.27227 23.60224 26.16713  1.000 34.51892 ? 127 GLN A OE1 1 
ATOM   1014 N  NE2 . GLN A 1 127 ? -36.80305 21.64683 27.14374  1.000 36.15288 ? 127 GLN A NE2 1 
ATOM   1015 N  N   . ASN A 1 128 ? -33.13258 23.57923 21.68658  1.000 25.55001 ? 128 ASN A N   1 
ATOM   1016 C  CA  . ASN A 1 128 ? -32.88784 24.43253 20.53245  1.000 28.47286 ? 128 ASN A CA  1 
ATOM   1017 C  C   . ASN A 1 128 ? -32.31606 23.62987 19.37731  1.000 27.08526 ? 128 ASN A C   1 
ATOM   1018 O  O   . ASN A 1 128 ? -32.69756 23.84442 18.22051  1.000 23.93653 ? 128 ASN A O   1 
ATOM   1019 C  CB  . ASN A 1 128 ? -31.96099 25.57978 20.91109  1.000 24.06758 ? 128 ASN A CB  1 
ATOM   1020 C  CG  . ASN A 1 128 ? -32.66564 26.61934 21.74611  1.000 30.65601 ? 128 ASN A CG  1 
ATOM   1021 O  OD1 . ASN A 1 128 ? -33.89481 26.68675 21.73613  1.000 32.90527 ? 128 ASN A OD1 1 
ATOM   1022 N  ND2 . ASN A 1 128 ? -31.90183 27.44020 22.46975  1.000 28.07409 ? 128 ASN A ND2 1 
ATOM   1023 N  N   . LYS A 1 129 ? -31.41670 22.68843 19.67394  1.000 22.65054 ? 129 LYS A N   1 
ATOM   1024 C  CA  . LYS A 1 129 ? -30.87222 21.84267 18.62283  1.000 25.30951 ? 129 LYS A CA  1 
ATOM   1025 C  C   . LYS A 1 129 ? -31.98830 21.09470 17.90844  1.000 25.74741 ? 129 LYS A C   1 
ATOM   1026 O  O   . LYS A 1 129 ? -32.06513 21.09843 16.67600  1.000 22.13430 ? 129 LYS A O   1 
ATOM   1027 C  CB  . LYS A 1 129 ? -29.84321 20.86677 19.19751  1.000 22.99963 ? 129 LYS A CB  1 
ATOM   1028 C  CG  . LYS A 1 129 ? -29.37957 19.82762 18.19462  1.000 20.44934 ? 129 LYS A CG  1 
ATOM   1029 C  CD  . LYS A 1 129 ? -28.43043 18.81604 18.81782  1.000 25.87538 ? 129 LYS A CD  1 
ATOM   1030 C  CE  . LYS A 1 129 ? -28.15171 17.66616 17.86760  1.000 21.96360 ? 129 LYS A CE  1 
ATOM   1031 N  NZ  . LYS A 1 129 ? -27.08330 16.75147 18.37266  1.000 22.97254 ? 129 LYS A NZ  1 
ATOM   1032 N  N   . GLN A 1 130 ? -32.88679 20.47310 18.66992  1.000 23.61545 ? 130 GLN A N   1 
ATOM   1033 C  CA  . GLN A 1 130 ? -33.95216 19.70613 18.04429  1.000 26.47166 ? 130 GLN A CA  1 
ATOM   1034 C  C   . GLN A 1 130 ? -34.89637 20.61383 17.26322  1.000 23.59167 ? 130 GLN A C   1 
ATOM   1035 O  O   . GLN A 1 130 ? -35.37485 20.24421 16.18418  1.000 22.90854 ? 130 GLN A O   1 
ATOM   1036 C  CB  . GLN A 1 130 ? -34.70475 18.90565 19.10980  1.000 32.16931 ? 130 GLN A CB  1 
ATOM   1037 C  CG  . GLN A 1 130 ? -33.82797 17.89350 19.82735  1.000 30.55854 ? 130 GLN A CG  1 
ATOM   1038 C  CD  . GLN A 1 130 ? -33.20142 16.88428 18.86939  1.000 30.25026 ? 130 GLN A CD  1 
ATOM   1039 O  OE1 . GLN A 1 130 ? -33.82594 16.46884 17.89134  1.000 37.50516 ? 130 GLN A OE1 1 
ATOM   1040 N  NE2 . GLN A 1 130 ? -31.96848 16.48189 19.15183  1.000 24.47410 ? 130 GLN A NE2 1 
ATOM   1041 N  N   . LEU A 1 131 ? -35.17549 21.80277 17.79174  1.000 20.63654 ? 131 LEU A N   1 
ATOM   1042 C  CA  . LEU A 1 131 ? -36.02314 22.74791 17.07942  1.000 23.46064 ? 131 LEU A CA  1 
ATOM   1043 C  C   . LEU A 1 131 ? -35.37238 23.17992 15.77095  1.000 23.17218 ? 131 LEU A C   1 
ATOM   1044 O  O   . LEU A 1 131 ? -36.02011 23.20326 14.71771  1.000 21.30012 ? 131 LEU A O   1 
ATOM   1045 C  CB  . LEU A 1 131 ? -36.30894 23.95655 17.96353  1.000 18.90512 ? 131 LEU A CB  1 
ATOM   1046 C  CG  . LEU A 1 131 ? -37.14823 25.06617 17.33849  1.000 20.92291 ? 131 LEU A CG  1 
ATOM   1047 C  CD1 . LEU A 1 131 ? -38.46094 24.50313 16.78533  1.000 16.99861 ? 131 LEU A CD1 1 
ATOM   1048 C  CD2 . LEU A 1 131 ? -37.40884 26.15773 18.37482  1.000 22.87657 ? 131 LEU A CD2 1 
ATOM   1049 N  N   . LEU A 1 132 ? -34.08554 23.52600 15.82046  1.000 21.45502 ? 132 LEU A N   1 
ATOM   1050 C  CA  . LEU A 1 132 ? -33.39007 23.92349 14.60476  1.000 17.96244 ? 132 LEU A CA  1 
ATOM   1051 C  C   . LEU A 1 132 ? -33.38512 22.78895 13.58781  1.000 20.48104 ? 132 LEU A C   1 
ATOM   1052 O  O   . LEU A 1 132 ? -33.65228 23.00753 12.40048  1.000 15.85908 ? 132 LEU A O   1 
ATOM   1053 C  CB  . LEU A 1 132 ? -31.96559 24.36088 14.94190  1.000 18.04652 ? 132 LEU A CB  1 
ATOM   1054 C  CG  . LEU A 1 132 ? -31.10511 24.75912 13.74478  1.000 19.43926 ? 132 LEU A CG  1 
ATOM   1055 C  CD1 . LEU A 1 132 ? -31.68858 25.98749 13.04123  1.000 14.68267 ? 132 LEU A CD1 1 
ATOM   1056 C  CD2 . LEU A 1 132 ? -29.66513 24.99920 14.18527  1.000 17.66013 ? 132 LEU A CD2 1 
ATOM   1057 N  N   . LEU A 1 133 ? -33.10857 21.56193 14.04290  1.000 17.98480 ? 133 LEU A N   1 
ATOM   1058 C  CA  . LEU A 1 133 ? -33.07320 20.42695 13.13210  1.000 18.54386 ? 133 LEU A CA  1 
ATOM   1059 C  C   . LEU A 1 133 ? -34.43938 20.16696 12.50563  1.000 22.03751 ? 133 LEU A C   1 
ATOM   1060 O  O   . LEU A 1 133 ? -34.51282 19.73919 11.34562  1.000 19.61009 ? 133 LEU A O   1 
ATOM   1061 C  CB  . LEU A 1 133 ? -32.54520 19.19062 13.86729  1.000 16.17320 ? 133 LEU A CB  1 
ATOM   1062 C  CG  . LEU A 1 133 ? -31.07024 19.31870 14.28649  1.000 19.76713 ? 133 LEU A CG  1 
ATOM   1063 C  CD1 . LEU A 1 133 ? -30.56854 18.07349 15.02151  1.000 16.57468 ? 133 LEU A CD1 1 
ATOM   1064 C  CD2 . LEU A 1 133 ? -30.20007 19.61743 13.06186  1.000 17.27937 ? 133 LEU A CD2 1 
ATOM   1065 N  N   . LYS A 1 134 ? -35.52510 20.44791 13.24094  1.000 22.06416 ? 134 LYS A N   1 
ATOM   1066 C  CA  . LYS A 1 134 ? -36.86326 20.27603 12.68968  1.000 20.26224 ? 134 LYS A CA  1 
ATOM   1067 C  C   . LYS A 1 134 ? -37.12804 21.33606 11.61837  1.000 20.03544 ? 134 LYS A C   1 
ATOM   1068 O  O   . LYS A 1 134 ? -37.65292 21.03642 10.54064  1.000 19.34693 ? 134 LYS A O   1 
ATOM   1069 C  CB  . LYS A 1 134 ? -37.91012 20.34044 13.81290  1.000 18.72774 ? 134 LYS A CB  1 
ATOM   1070 C  CG  . LYS A 1 134 ? -39.27064 19.73058 13.45814  1.000 25.65753 ? 134 LYS A CG  1 
ATOM   1071 C  CD  . LYS A 1 134 ? -39.07351 18.28347 13.01606  1.000 41.41630 ? 134 LYS A CD  1 
ATOM   1072 C  CE  . LYS A 1 134 ? -40.02879 17.85885 11.87216  1.000 49.71544 ? 134 LYS A CE  1 
ATOM   1073 N  NZ  . LYS A 1 134 ? -39.50454 18.05912 10.45329  1.000 44.21165 ? 134 LYS A NZ  1 
ATOM   1074 N  N   . ARG A 1 135 ? -36.75446 22.58680 11.89083  1.000 17.46143 ? 135 ARG A N   1 
ATOM   1075 C  CA  . ARG A 1 135 ? -36.87509 23.64058 10.88458  1.000 17.30452 ? 135 ARG A CA  1 
ATOM   1076 C  C   . ARG A 1 135 ? -36.06691 23.31237 9.63788   1.000 16.60293 ? 135 ARG A C   1 
ATOM   1077 O  O   . ARG A 1 135 ? -36.54189 23.50582 8.51055   1.000 15.36554 ? 135 ARG A O   1 
ATOM   1078 C  CB  . ARG A 1 135 ? -36.40727 24.96806 11.47913  1.000 16.07362 ? 135 ARG A CB  1 
ATOM   1079 C  CG  . ARG A 1 135 ? -37.35360 25.55206 12.48658  1.000 18.83307 ? 135 ARG A CG  1 
ATOM   1080 C  CD  . ARG A 1 135 ? -36.67701 26.64209 13.30268  1.000 18.15260 ? 135 ARG A CD  1 
ATOM   1081 N  NE  . ARG A 1 135 ? -37.65147 27.33415 14.13281  1.000 21.18562 ? 135 ARG A NE  1 
ATOM   1082 C  CZ  . ARG A 1 135 ? -37.35180 28.23371 15.06584  1.000 21.77932 ? 135 ARG A CZ  1 
ATOM   1083 N  NH1 . ARG A 1 135 ? -36.08780 28.55055 15.29942  1.000 17.68243 ? 135 ARG A NH1 1 
ATOM   1084 N  NH2 . ARG A 1 135 ? -38.32530 28.81590 15.76370  1.000 18.74343 ? 135 ARG A NH2 1 
ATOM   1085 N  N   . LEU A 1 136 ? -34.82972 22.84670 9.83108   1.000 14.28295 ? 136 LEU A N   1 
ATOM   1086 C  CA  . LEU A 1 136 ? -33.99046 22.41327 8.72481   1.000 15.65179 ? 136 LEU A CA  1 
ATOM   1087 C  C   . LEU A 1 136 ? -34.70080 21.36760 7.88809   1.000 16.11819 ? 136 LEU A C   1 
ATOM   1088 O  O   . LEU A 1 136 ? -34.78478 21.49116 6.65857   1.000 15.49643 ? 136 LEU A O   1 
ATOM   1089 C  CB  . LEU A 1 136 ? -32.67051 21.85188 9.26047   1.000 13.37381 ? 136 LEU A CB  1 
ATOM   1090 C  CG  . LEU A 1 136 ? -31.73776 21.26619 8.19148   1.000 15.42266 ? 136 LEU A CG  1 
ATOM   1091 C  CD1 . LEU A 1 136 ? -31.43218 22.32855 7.15106   1.000 10.63873 ? 136 LEU A CD1 1 
ATOM   1092 C  CD2 . LEU A 1 136 ? -30.43834 20.73918 8.80682   1.000 14.47861 ? 136 LEU A CD2 1 
ATOM   1093 N  N   . GLU A 1 137 ? -35.22479 20.32745 8.54453   1.000 14.81404 ? 137 GLU A N   1 
ATOM   1094 C  CA  . GLU A 1 137 ? -35.88340 19.24472 7.81974   1.000 16.08656 ? 137 GLU A CA  1 
ATOM   1095 C  C   . GLU A 1 137 ? -37.08536 19.75015 7.02250   1.000 15.07848 ? 137 GLU A C   1 
ATOM   1096 O  O   . GLU A 1 137 ? -37.28310 19.33840 5.87281   1.000 13.24292 ? 137 GLU A O   1 
ATOM   1097 C  CB  . GLU A 1 137 ? -36.30282 18.13275 8.79111   1.000 18.69055 ? 137 GLU A CB  1 
ATOM   1098 C  CG  . GLU A 1 137 ? -37.15740 17.04466 8.12246   1.000 28.93389 ? 137 GLU A CG  1 
ATOM   1099 C  CD  . GLU A 1 137 ? -37.14893 15.71501 8.85907   1.000 40.68043 ? 137 GLU A CD  1 
ATOM   1100 O  OE1 . GLU A 1 137 ? -37.92360 14.81472 8.45668   1.000 36.33889 ? 137 GLU A OE1 1 
ATOM   1101 O  OE2 . GLU A 1 137 ? -36.36787 15.56946 9.82903   1.000 49.74521 ? 137 GLU A OE2 1 
ATOM   1102 N  N   . THR A 1 138 ? -37.88880 20.65526 7.60757   1.000 12.97057 ? 138 THR A N   1 
ATOM   1103 C  CA  . THR A 1 138 ? -39.07251 21.17699 6.91283   1.000 16.21040 ? 138 THR A CA  1 
ATOM   1104 C  C   . THR A 1 138 ? -38.68418 22.01602 5.69715   1.000 15.60409 ? 138 THR A C   1 
ATOM   1105 O  O   . THR A 1 138 ? -39.34276 21.94941 4.65008   1.000 15.15338 ? 138 THR A O   1 
ATOM   1106 C  CB  . THR A 1 138 ? -39.93177 22.01439 7.87202   1.000 16.09110 ? 138 THR A CB  1 
ATOM   1107 O  OG1 . THR A 1 138 ? -40.38057 21.20885 8.96756   1.000 19.87576 ? 138 THR A OG1 1 
ATOM   1108 C  CG2 . THR A 1 138 ? -41.15003 22.57775 7.16351   1.000 12.75115 ? 138 THR A CG2 1 
ATOM   1109 N  N   . HIS A 1 139 ? -37.64180 22.84091 5.83759   1.000 16.26322 ? 139 HIS A N   1 
ATOM   1110 C  CA  . HIS A 1 139 ? -37.13249 23.62601 4.71533   1.000 12.78507 ? 139 HIS A CA  1 
ATOM   1111 C  C   . HIS A 1 139 ? -36.74653 22.71476 3.55551   1.000 11.57273 ? 139 HIS A C   1 
ATOM   1112 O  O   . HIS A 1 139 ? -37.25917 22.85530 2.44084   1.000 11.96542 ? 139 HIS A O   1 
ATOM   1113 C  CB  . HIS A 1 139 ? -35.94126 24.45813 5.19563   1.000 9.82791  ? 139 HIS A CB  1 
ATOM   1114 C  CG  . HIS A 1 139 ? -35.28006 25.27728 4.12802   1.000 11.02081 ? 139 HIS A CG  1 
ATOM   1115 N  ND1 . HIS A 1 139 ? -35.78459 26.48207 3.69644   1.000 7.25876  ? 139 HIS A ND1 1 
ATOM   1116 C  CD2 . HIS A 1 139 ? -34.13251 25.07952 3.43401   1.000 11.35378 ? 139 HIS A CD2 1 
ATOM   1117 C  CE1 . HIS A 1 139 ? -34.98297 26.99235 2.78058   1.000 10.26193 ? 139 HIS A CE1 1 
ATOM   1118 N  NE2 . HIS A 1 139 ? -33.97266 26.16038 2.60154   1.000 13.51777 ? 139 HIS A NE2 1 
ATOM   1119 N  N   . ILE A 1 140 ? -35.90634 21.71873 3.83367   1.000 11.72029 ? 140 ILE A N   1 
ATOM   1120 C  CA  . ILE A 1 140 ? -35.47172 20.76757 2.81590   1.000 12.73073 ? 140 ILE A CA  1 
ATOM   1121 C  C   . ILE A 1 140 ? -36.65301 19.96356 2.27731   1.000 14.94969 ? 140 ILE A C   1 
ATOM   1122 O  O   . ILE A 1 140 ? -36.78182 19.76421 1.06000   1.000 11.52291 ? 140 ILE A O   1 
ATOM   1123 C  CB  . ILE A 1 140 ? -34.36797 19.86065 3.39672   1.000 11.95202 ? 140 ILE A CB  1 
ATOM   1124 C  CG1 . ILE A 1 140 ? -33.10093 20.68181 3.63669   1.000 15.92009 ? 140 ILE A CG1 1 
ATOM   1125 C  CG2 . ILE A 1 140 ? -34.06354 18.66320 2.47824   1.000 12.08417 ? 140 ILE A CG2 1 
ATOM   1126 C  CD1 . ILE A 1 140 ? -32.04098 19.94495 4.39058   1.000 12.29899 ? 140 ILE A CD1 1 
ATOM   1127 N  N   . LYS A 1 141 ? -37.53562 19.49444 3.16737   1.000 15.36181 ? 141 LYS A N   1 
ATOM   1128 C  CA  . LYS A 1 141 ? -38.67175 18.68060 2.73012   1.000 14.18216 ? 141 LYS A CA  1 
ATOM   1129 C  C   . LYS A 1 141 ? -39.52146 19.42345 1.71312   1.000 11.26096 ? 141 LYS A C   1 
ATOM   1130 O  O   . LYS A 1 141 ? -39.84707 18.88332 0.64897   1.000 16.07204 ? 141 LYS A O   1 
ATOM   1131 C  CB  . LYS A 1 141 ? -39.52507 18.27051 3.93109   1.000 19.18214 ? 141 LYS A CB  1 
ATOM   1132 C  CG  . LYS A 1 141 ? -40.88804 17.62831 3.59804   1.000 10.89264 ? 141 LYS A CG  1 
ATOM   1133 C  CD  . LYS A 1 141 ? -41.61200 17.29983 4.91949   1.000 15.62714 ? 141 LYS A CD  1 
ATOM   1134 C  CE  . LYS A 1 141 ? -42.99663 16.69231 4.69809   1.000 14.87380 ? 141 LYS A CE  1 
ATOM   1135 N  NZ  . LYS A 1 141 ? -43.91996 17.63629 3.97920   1.000 11.73546 ? 141 LYS A NZ  1 
ATOM   1136 N  N   . THR A 1 142 ? -39.87086 20.67747 2.01779   1.000 12.39120 ? 142 THR A N   1 
ATOM   1137 C  CA  . THR A 1 142 ? -40.74892 21.44690 1.14181   1.000 11.62519 ? 142 THR A CA  1 
ATOM   1138 C  C   . THR A 1 142 ? -40.10927 21.66256 -0.21743  1.000 11.26600 ? 142 THR A C   1 
ATOM   1139 O  O   . THR A 1 142 ? -40.77002 21.50780 -1.25019  1.000 10.44747 ? 142 THR A O   1 
ATOM   1140 C  CB  . THR A 1 142 ? -41.09905 22.79628 1.78241   1.000 13.17283 ? 142 THR A CB  1 
ATOM   1141 O  OG1 . THR A 1 142 ? -41.64353 22.57826 3.08753   1.000 15.25781 ? 142 THR A OG1 1 
ATOM   1142 C  CG2 . THR A 1 142 ? -42.12047 23.54638 0.94116   1.000 10.15759 ? 142 THR A CG2 1 
ATOM   1143 N  N   . ILE A 1 143 ? -38.81926 22.00241 -0.23801  1.000 12.97839 ? 143 ILE A N   1 
ATOM   1144 C  CA  . ILE A 1 143 ? -38.12625 22.24477 -1.50363  1.000 12.98568 ? 143 ILE A CA  1 
ATOM   1145 C  C   . ILE A 1 143 ? -38.00601 20.95642 -2.30983  1.000 11.68385 ? 143 ILE A C   1 
ATOM   1146 O  O   . ILE A 1 143 ? -38.29311 20.92389 -3.51151  1.000 12.50888 ? 143 ILE A O   1 
ATOM   1147 C  CB  . ILE A 1 143 ? -36.74200 22.86306 -1.24539  1.000 10.94120 ? 143 ILE A CB  1 
ATOM   1148 C  CG1 . ILE A 1 143 ? -36.88805 24.23959 -0.57940  1.000 9.36585  ? 143 ILE A CG1 1 
ATOM   1149 C  CG2 . ILE A 1 143 ? -35.92963 22.89358 -2.54946  1.000 9.22791  ? 143 ILE A CG2 1 
ATOM   1150 C  CD1 . ILE A 1 143 ? -35.62840 24.69993 0.16820   1.000 10.63131 ? 143 ILE A CD1 1 
ATOM   1151 N  N   . VAL A 1 144 ? -37.55510 19.88031 -1.66989  1.000 11.04011 ? 144 VAL A N   1 
ATOM   1152 C  CA  . VAL A 1 144 ? -37.29651 18.66445 -2.42193  1.000 12.75327 ? 144 VAL A CA  1 
ATOM   1153 C  C   . VAL A 1 144 ? -38.60471 18.02408 -2.88875  1.000 14.09786 ? 144 VAL A C   1 
ATOM   1154 O  O   . VAL A 1 144 ? -38.67574 17.47089 -3.99550  1.000 10.47848 ? 144 VAL A O   1 
ATOM   1155 C  CB  . VAL A 1 144 ? -36.43404 17.71006 -1.57748  1.000 13.50586 ? 144 VAL A CB  1 
ATOM   1156 C  CG1 . VAL A 1 144 ? -36.30269 16.39447 -2.27151  1.000 13.36726 ? 144 VAL A CG1 1 
ATOM   1157 C  CG2 . VAL A 1 144 ? -35.04179 18.29944 -1.37868  1.000 12.24816 ? 144 VAL A CG2 1 
ATOM   1158 N  N   . GLU A 1 145 ? -39.66534 18.12176 -2.08720  1.000 11.18023 ? 145 GLU A N   1 
ATOM   1159 C  CA  . GLU A 1 145 ? -40.95575 17.58920 -2.51451  1.000 12.80563 ? 145 GLU A CA  1 
ATOM   1160 C  C   . GLU A 1 145 ? -41.45067 18.29005 -3.76904  1.000 10.60022 ? 145 GLU A C   1 
ATOM   1161 O  O   . GLU A 1 145 ? -42.10975 17.66489 -4.59972  1.000 11.42958 ? 145 GLU A O   1 
ATOM   1162 C  CB  . GLU A 1 145 ? -41.98673 17.70806 -1.37345  1.000 11.83036 ? 145 GLU A CB  1 
ATOM   1163 C  CG  . GLU A 1 145 ? -41.83758 16.60731 -0.31053  1.000 11.54695 ? 145 GLU A CG  1 
ATOM   1164 C  CD  . GLU A 1 145 ? -42.80192 16.72307 0.85996   1.000 11.60637 ? 145 GLU A CD  1 
ATOM   1165 O  OE1 . GLU A 1 145 ? -43.16921 17.84171 1.27234   1.000 11.96130 ? 145 GLU A OE1 1 
ATOM   1166 O  OE2 . GLU A 1 145 ? -43.19066 15.67295 1.38454   1.000 12.09272 ? 145 GLU A OE2 1 
ATOM   1167 N  N   . ARG A 1 146 ? -41.13661 19.57894 -3.93516  1.000 10.73199 ? 146 ARG A N   1 
ATOM   1168 C  CA  . ARG A 1 146 ? -41.56986 20.29156 -5.13587  1.000 10.75131 ? 146 ARG A CA  1 
ATOM   1169 C  C   . ARG A 1 146 ? -40.70283 19.96315 -6.35583  1.000 13.46874 ? 146 ARG A C   1 
ATOM   1170 O  O   . ARG A 1 146 ? -41.23149 19.83767 -7.46218  1.000 13.69749 ? 146 ARG A O   1 
ATOM   1171 C  CB  . ARG A 1 146 ? -41.57022 21.79996 -4.88439  1.000 10.08829 ? 146 ARG A CB  1 
ATOM   1172 C  CG  . ARG A 1 146 ? -42.11886 22.63358 -6.05077  1.000 10.11441 ? 146 ARG A CG  1 
ATOM   1173 C  CD  . ARG A 1 146 ? -42.06374 24.10064 -5.69337  1.000 14.78386 ? 146 ARG A CD  1 
ATOM   1174 N  NE  . ARG A 1 146 ? -42.65967 24.99242 -6.68614  1.000 14.01023 ? 146 ARG A NE  1 
ATOM   1175 C  CZ  . ARG A 1 146 ? -43.96086 25.25933 -6.77749  1.000 12.17051 ? 146 ARG A CZ  1 
ATOM   1176 N  NH1 . ARG A 1 146 ? -44.82680 24.68000 -5.95975  1.000 8.17998  ? 146 ARG A NH1 1 
ATOM   1177 N  NH2 . ARG A 1 146 ? -44.39866 26.09765 -7.70766  1.000 13.85852 ? 146 ARG A NH2 1 
ATOM   1178 N  N   . TYR A 1 147 ? -39.38146 19.79321 -6.18604  1.000 11.29135 ? 147 TYR A N   1 
ATOM   1179 C  CA  . TYR A 1 147 ? -38.44971 19.75587 -7.31726  1.000 10.98997 ? 147 TYR A CA  1 
ATOM   1180 C  C   . TYR A 1 147 ? -37.83759 18.38820 -7.61399  1.000 14.18943 ? 147 TYR A C   1 
ATOM   1181 O  O   . TYR A 1 147 ? -37.07929 18.27905 -8.58421  1.000 15.24623 ? 147 TYR A O   1 
ATOM   1182 C  CB  . TYR A 1 147 ? -37.31483 20.76889 -7.09109  1.000 8.90605  ? 147 TYR A CB  1 
ATOM   1183 C  CG  . TYR A 1 147 ? -37.79220 22.20072 -7.17713  1.000 10.18923 ? 147 TYR A CG  1 
ATOM   1184 C  CD1 . TYR A 1 147 ? -38.59337 22.61731 -8.22824  1.000 9.63669  ? 147 TYR A CD1 1 
ATOM   1185 C  CD2 . TYR A 1 147 ? -37.48455 23.12120 -6.18794  1.000 10.91007 ? 147 TYR A CD2 1 
ATOM   1186 C  CE1 . TYR A 1 147 ? -39.04645 23.92704 -8.30820  1.000 12.06828 ? 147 TYR A CE1 1 
ATOM   1187 C  CE2 . TYR A 1 147 ? -37.94714 24.43052 -6.25264  1.000 13.19317 ? 147 TYR A CE2 1 
ATOM   1188 C  CZ  . TYR A 1 147 ? -38.72251 24.82752 -7.32283  1.000 13.34327 ? 147 TYR A CZ  1 
ATOM   1189 O  OH  . TYR A 1 147 ? -39.17556 26.13307 -7.40622  1.000 14.15499 ? 147 TYR A OH  1 
ATOM   1190 N  N   . LYS A 1 148 ? -38.15309 17.34450 -6.83067  1.000 12.25303 ? 148 LYS A N   1 
ATOM   1191 C  CA  . LYS A 1 148 ? -37.43542 16.06971 -6.92418  1.000 15.35327 ? 148 LYS A CA  1 
ATOM   1192 C  C   . LYS A 1 148 ? -37.50958 15.44135 -8.31137  1.000 15.64073 ? 148 LYS A C   1 
ATOM   1193 O  O   . LYS A 1 148 ? -36.60925 14.68125 -8.68545  1.000 15.52871 ? 148 LYS A O   1 
ATOM   1194 C  CB  . LYS A 1 148 ? -37.97565 15.06506 -5.89784  1.000 15.79117 ? 148 LYS A CB  1 
ATOM   1195 C  CG  . LYS A 1 148 ? -39.46250 14.73362 -6.07472  1.000 16.66587 ? 148 LYS A CG  1 
ATOM   1196 C  CD  . LYS A 1 148 ? -39.92309 13.70573 -5.04175  1.000 21.08286 ? 148 LYS A CD  1 
ATOM   1197 C  CE  . LYS A 1 148 ? -41.40636 13.39575 -5.19291  1.000 25.74592 ? 148 LYS A CE  1 
ATOM   1198 N  NZ  . LYS A 1 148 ? -41.70958 12.79573 -6.52585  1.000 33.18237 ? 148 LYS A NZ  1 
ATOM   1199 N  N   . ASP A 1 149 ? -38.57700 15.70440 -9.07190  1.000 14.58193 ? 149 ASP A N   1 
ATOM   1200 C  CA  . ASP A 1 149 ? -38.69040 15.11841 -10.39931 1.000 16.17688 ? 149 ASP A CA  1 
ATOM   1201 C  C   . ASP A 1 149 ? -38.01456 15.95288 -11.48116 1.000 18.12683 ? 149 ASP A C   1 
ATOM   1202 O  O   . ASP A 1 149 ? -37.88505 15.46891 -12.60642 1.000 17.19245 ? 149 ASP A O   1 
ATOM   1203 C  CB  . ASP A 1 149 ? -40.16155 14.90377 -10.77837 1.000 17.80876 ? 149 ASP A CB  1 
ATOM   1204 C  CG  . ASP A 1 149 ? -40.85709 13.85224 -9.89230  1.000 23.59165 ? 149 ASP A CG  1 
ATOM   1205 O  OD1 . ASP A 1 149 ? -40.19472 12.89387 -9.45528  1.000 24.53384 ? 149 ASP A OD1 1 
ATOM   1206 O  OD2 . ASP A 1 149 ? -42.06847 13.98881 -9.63184  1.000 30.72593 ? 149 ASP A OD2 1 
ATOM   1207 N  N   . ASP A 1 150 ? -37.58702 17.18387 -11.17841 1.000 12.63807 ? 150 ASP A N   1 
ATOM   1208 C  CA  . ASP A 1 150 ? -36.98131 18.07328 -12.17276 1.000 15.11145 ? 150 ASP A CA  1 
ATOM   1209 C  C   . ASP A 1 150 ? -35.49586 18.31267 -11.97712 1.000 11.02121 ? 150 ASP A C   1 
ATOM   1210 O  O   . ASP A 1 150 ? -34.79929 18.58513 -12.95732 1.000 14.67753 ? 150 ASP A O   1 
ATOM   1211 C  CB  . ASP A 1 150 ? -37.66501 19.44828 -12.16828 1.000 13.98956 ? 150 ASP A CB  1 
ATOM   1212 C  CG  . ASP A 1 150 ? -39.16075 19.35477 -12.36844 1.000 21.41462 ? 150 ASP A CG  1 
ATOM   1213 O  OD1 . ASP A 1 150 ? -39.57894 18.56172 -13.23576 1.000 21.87287 ? 150 ASP A OD1 1 
ATOM   1214 O  OD2 . ASP A 1 150 ? -39.90513 20.06971 -11.65353 1.000 28.04530 ? 150 ASP A OD2 1 
ATOM   1215 N  N   . ILE A 1 151 ? -35.00667 18.29138 -10.74150 1.000 9.63328  ? 151 ILE A N   1 
ATOM   1216 C  CA  . ILE A 1 151 ? -33.64635 18.71306 -10.43075 1.000 10.20058 ? 151 ILE A CA  1 
ATOM   1217 C  C   . ILE A 1 151 ? -32.85241 17.48499 -10.01882 1.000 14.91519 ? 151 ILE A C   1 
ATOM   1218 O  O   . ILE A 1 151 ? -33.17260 16.83066 -9.01563  1.000 10.57543 ? 151 ILE A O   1 
ATOM   1219 C  CB  . ILE A 1 151 ? -33.62764 19.78858 -9.33526  1.000 14.58874 ? 151 ILE A CB  1 
ATOM   1220 C  CG1 . ILE A 1 151 ? -34.39702 21.02975 -9.81394  1.000 10.06228 ? 151 ILE A CG1 1 
ATOM   1221 C  CG2 . ILE A 1 151 ? -32.19357 20.12310 -8.95358  1.000 9.29696  ? 151 ILE A CG2 1 
ATOM   1222 C  CD1 . ILE A 1 151 ? -34.32718 22.21397 -8.84234  1.000 9.11859  ? 151 ILE A CD1 1 
ATOM   1223 N  N   . LYS A 1 152 ? -31.82861 17.15757 -10.80663 1.000 10.19911 ? 152 LYS A N   1 
ATOM   1224 C  CA  . LYS A 1 152 ? -31.07498 15.93658 -10.55761 1.000 13.60874 ? 152 LYS A CA  1 
ATOM   1225 C  C   . LYS A 1 152 ? -29.95481 16.13484 -9.53794  1.000 13.85341 ? 152 LYS A C   1 
ATOM   1226 O  O   . LYS A 1 152 ? -29.63809 15.19975 -8.79984  1.000 14.10890 ? 152 LYS A O   1 
ATOM   1227 C  CB  . LYS A 1 152 ? -30.49361 15.40935 -11.87290 1.000 15.71160 ? 152 LYS A CB  1 
ATOM   1228 C  CG  . LYS A 1 152 ? -29.75275 14.07643 -11.75297 1.000 16.64253 ? 152 LYS A CG  1 
ATOM   1229 C  CD  . LYS A 1 152 ? -29.33001 13.58400 -13.13219 1.000 32.70084 ? 152 LYS A CD  1 
ATOM   1230 C  CE  . LYS A 1 152 ? -28.84151 12.14019 -13.07829 1.000 40.77801 ? 152 LYS A CE  1 
ATOM   1231 N  NZ  . LYS A 1 152 ? -29.58947 11.35285 -12.03511 1.000 45.76637 ? 152 LYS A NZ  1 
ATOM   1232 N  N   . TYR A 1 153 ? -29.34851 17.32402 -9.47341  1.000 10.25408 ? 153 TYR A N   1 
ATOM   1233 C  CA  . TYR A 1 153 ? -28.12976 17.54133 -8.69495  1.000 10.82946 ? 153 TYR A CA  1 
ATOM   1234 C  C   . TYR A 1 153 ? -28.38052 18.58967 -7.62401  1.000 9.93896  ? 153 TYR A C   1 
ATOM   1235 O  O   . TYR A 1 153 ? -28.93128 19.65429 -7.91138  1.000 9.27283  ? 153 TYR A O   1 
ATOM   1236 C  CB  . TYR A 1 153 ? -26.96556 17.97983 -9.59872  1.000 11.53237 ? 153 TYR A CB  1 
ATOM   1237 C  CG  . TYR A 1 153 ? -26.66917 16.99560 -10.70767 1.000 11.90687 ? 153 TYR A CG  1 
ATOM   1238 C  CD1 . TYR A 1 153 ? -25.94522 15.83601 -10.45826 1.000 15.51787 ? 153 TYR A CD1 1 
ATOM   1239 C  CD2 . TYR A 1 153 ? -27.13072 17.21405 -11.99930 1.000 15.66573 ? 153 TYR A CD2 1 
ATOM   1240 C  CE1 . TYR A 1 153 ? -25.67791 14.91449 -11.47642 1.000 16.57614 ? 153 TYR A CE1 1 
ATOM   1241 C  CE2 . TYR A 1 153 ? -26.87341 16.29622 -13.02317 1.000 18.87006 ? 153 TYR A CE2 1 
ATOM   1242 C  CZ  . TYR A 1 153 ? -26.14681 15.15252 -12.74756 1.000 16.64980 ? 153 TYR A CZ  1 
ATOM   1243 O  OH  . TYR A 1 153 ? -25.89337 14.24808 -13.74844 1.000 29.21387 ? 153 TYR A OH  1 
ATOM   1244 N  N   . TRP A 1 154 ? -27.95139 18.29931 -6.39724  1.000 10.47335 ? 154 TRP A N   1 
ATOM   1245 C  CA  . TRP A 1 154 ? -28.29652 19.11303 -5.24119  1.000 9.48528  ? 154 TRP A CA  1 
ATOM   1246 C  C   . TRP A 1 154 ? -27.04503 19.43563 -4.44039  1.000 12.75805 ? 154 TRP A C   1 
ATOM   1247 O  O   . TRP A 1 154 ? -26.37542 18.52282 -3.94629  1.000 11.95843 ? 154 TRP A O   1 
ATOM   1248 C  CB  . TRP A 1 154 ? -29.30568 18.37674 -4.35744  1.000 12.64330 ? 154 TRP A CB  1 
ATOM   1249 C  CG  . TRP A 1 154 ? -30.62505 18.21047 -5.00191  1.000 10.48338 ? 154 TRP A CG  1 
ATOM   1250 C  CD1 . TRP A 1 154 ? -30.96543 17.29836 -5.96086  1.000 11.28039 ? 154 TRP A CD1 1 
ATOM   1251 C  CD2 . TRP A 1 154 ? -31.79302 18.99472 -4.75060  1.000 10.29006 ? 154 TRP A CD2 1 
ATOM   1252 N  NE1 . TRP A 1 154 ? -32.28711 17.46479 -6.31583  1.000 12.19515 ? 154 TRP A NE1 1 
ATOM   1253 C  CE2 . TRP A 1 154 ? -32.81341 18.50638 -5.59415  1.000 10.44419 ? 154 TRP A CE2 1 
ATOM   1254 C  CE3 . TRP A 1 154 ? -32.07214 20.07700 -3.89840  1.000 9.52057  ? 154 TRP A CE3 1 
ATOM   1255 C  CZ2 . TRP A 1 154 ? -34.09760 19.05132 -5.60474  1.000 11.18720 ? 154 TRP A CZ2 1 
ATOM   1256 C  CZ3 . TRP A 1 154 ? -33.34190 20.61326 -3.90479  1.000 13.02746 ? 154 TRP A CZ3 1 
ATOM   1257 C  CH2 . TRP A 1 154 ? -34.34447 20.10038 -4.75403  1.000 11.33430 ? 154 TRP A CH2 1 
ATOM   1258 N  N   . ASP A 1 155 ? -26.73868 20.72711 -4.28902  1.000 12.44751 ? 155 ASP A N   1 
ATOM   1259 C  CA  . ASP A 1 155 ? -25.78839 21.14006 -3.25318  1.000 13.03453 ? 155 ASP A CA  1 
ATOM   1260 C  C   . ASP A 1 155 ? -26.54292 21.10150 -1.92798  1.000 11.09370 ? 155 ASP A C   1 
ATOM   1261 O  O   . ASP A 1 155 ? -27.32390 22.00273 -1.61881  1.000 11.09170 ? 155 ASP A O   1 
ATOM   1262 C  CB  . ASP A 1 155 ? -25.21662 22.52664 -3.53188  1.000 10.11252 ? 155 ASP A CB  1 
ATOM   1263 C  CG  . ASP A 1 155 ? -24.27555 22.55347 -4.72735  1.000 16.48093 ? 155 ASP A CG  1 
ATOM   1264 O  OD1 . ASP A 1 155 ? -23.53415 21.55557 -4.95956  1.000 15.25211 ? 155 ASP A OD1 1 
ATOM   1265 O  OD2 . ASP A 1 155 ? -24.27867 23.58507 -5.43999  1.000 13.07727 ? 155 ASP A OD2 1 
ATOM   1266 N  N   . VAL A 1 156 ? -26.33677 20.04330 -1.14246  1.000 10.87574 ? 156 VAL A N   1 
ATOM   1267 C  CA  . VAL A 1 156 ? -27.09556 19.89711 0.09810   1.000 10.75342 ? 156 VAL A CA  1 
ATOM   1268 C  C   . VAL A 1 156 ? -26.56305 20.85357 1.16018   1.000 11.36250 ? 156 VAL A C   1 
ATOM   1269 O  O   . VAL A 1 156 ? -27.32856 21.56943 1.81455   1.000 10.48074 ? 156 VAL A O   1 
ATOM   1270 C  CB  . VAL A 1 156 ? -27.06178 18.43613 0.58718   1.000 13.10255 ? 156 VAL A CB  1 
ATOM   1271 C  CG1 . VAL A 1 156 ? -27.76294 18.31755 1.94786   1.000 13.33654 ? 156 VAL A CG1 1 
ATOM   1272 C  CG2 . VAL A 1 156 ? -27.70742 17.51799 -0.42704  1.000 10.07420 ? 156 VAL A CG2 1 
ATOM   1273 N  N   . VAL A 1 157 ? -25.24285 20.86093 1.36557   1.000 12.88077 ? 157 VAL A N   1 
ATOM   1274 C  CA  . VAL A 1 157 ? -24.59875 21.79072 2.28295   1.000 14.00346 ? 157 VAL A CA  1 
ATOM   1275 C  C   . VAL A 1 157 ? -23.45748 22.46165 1.54098   1.000 15.26494 ? 157 VAL A C   1 
ATOM   1276 O  O   . VAL A 1 157 ? -22.87473 21.88986 0.61255   1.000 13.83920 ? 157 VAL A O   1 
ATOM   1277 C  CB  . VAL A 1 157 ? -24.07973 21.11241 3.57035   1.000 11.16453 ? 157 VAL A CB  1 
ATOM   1278 C  CG1 . VAL A 1 157 ? -25.19427 20.31697 4.23326   1.000 13.00897 ? 157 VAL A CG1 1 
ATOM   1279 C  CG2 . VAL A 1 157 ? -22.87644 20.22290 3.26376   1.000 10.47095 ? 157 VAL A CG2 1 
ATOM   1280 N  N   . GLU A 1 158 ? -23.13963 23.68337 1.96620   1.000 14.64853 ? 158 GLU A N   1 
ATOM   1281 C  CA  . GLU A 1 158 ? -22.12109 24.51226 1.33879   1.000 14.74941 ? 158 GLU A CA  1 
ATOM   1282 C  C   . GLU A 1 158 ? -21.20272 25.11803 2.39698   1.000 15.10889 ? 158 GLU A C   1 
ATOM   1283 O  O   . GLU A 1 158 ? -21.67818 25.71588 3.36754   1.000 15.77305 ? 158 GLU A O   1 
ATOM   1284 C  CB  . GLU A 1 158 ? -22.78651 25.61882 0.52036   1.000 15.40773 ? 158 GLU A CB  1 
ATOM   1285 C  CG  . GLU A 1 158 ? -21.83245 26.56688 -0.19161  1.000 14.91942 ? 158 GLU A CG  1 
ATOM   1286 C  CD  . GLU A 1 158 ? -22.58110 27.39174 -1.22237  1.000 18.26819 ? 158 GLU A CD  1 
ATOM   1287 O  OE1 . GLU A 1 158 ? -21.95606 28.14343 -1.98444  1.000 18.94701 ? 158 GLU A OE1 1 
ATOM   1288 O  OE2 . GLU A 1 158 ? -23.81876 27.28206 -1.26478  1.000 18.92776 ? 158 GLU A OE2 1 
ATOM   1289 N  N   . GLU A 1 159 ? -19.89096 24.95826 2.20636   1.000 12.53956 ? 159 GLU A N   1 
ATOM   1290 C  CA  . GLU A 1 159 ? -18.88050 25.66476 2.99781   1.000 14.29522 ? 159 GLU A CA  1 
ATOM   1291 C  C   . GLU A 1 159 ? -18.96331 25.31470 4.48143   1.000 13.82979 ? 159 GLU A C   1 
ATOM   1292 O  O   . GLU A 1 159 ? -18.84477 26.17826 5.34667   1.000 13.52438 ? 159 GLU A O   1 
ATOM   1293 C  CB  . GLU A 1 159 ? -18.98316 27.18168 2.78713   1.000 12.38875 ? 159 GLU A CB  1 
ATOM   1294 C  CG  . GLU A 1 159 ? -18.63762 27.60394 1.34950   1.000 15.18441 ? 159 GLU A CG  1 
ATOM   1295 C  CD  . GLU A 1 159 ? -18.89666 29.07619 1.05646   1.000 19.05477 ? 159 GLU A CD  1 
ATOM   1296 O  OE1 . GLU A 1 159 ? -19.16161 29.84367 2.01091   1.000 14.65828 ? 159 GLU A OE1 1 
ATOM   1297 O  OE2 . GLU A 1 159 ? -18.82583 29.46018 -0.14072  1.000 17.42857 ? 159 GLU A OE2 1 
ATOM   1298 N  N   . VAL A 1 160 ? -19.14107 24.02935 4.79052   1.000 11.40746 ? 160 VAL A N   1 
ATOM   1299 C  CA  . VAL A 1 160 ? -19.27106 23.62890 6.18847   1.000 13.95955 ? 160 VAL A CA  1 
ATOM   1300 C  C   . VAL A 1 160 ? -17.92294 23.33283 6.83828   1.000 17.42817 ? 160 VAL A C   1 
ATOM   1301 O  O   . VAL A 1 160 ? -17.87060 23.10136 8.05560   1.000 15.66313 ? 160 VAL A O   1 
ATOM   1302 C  CB  . VAL A 1 160 ? -20.22773 22.42697 6.32264   1.000 11.42799 ? 160 VAL A CB  1 
ATOM   1303 C  CG1 . VAL A 1 160 ? -21.55111 22.75160 5.66237   1.000 11.80763 ? 160 VAL A CG1 1 
ATOM   1304 C  CG2 . VAL A 1 160 ? -19.62034 21.17888 5.71201   1.000 14.31563 ? 160 VAL A CG2 1 
ATOM   1305 N  N   . VAL A 1 161 ? -16.83080 23.36596 6.07495   1.000 13.17091 ? 161 VAL A N   1 
ATOM   1306 C  CA  . VAL A 1 161 ? -15.48151 23.22083 6.60748   1.000 17.32870 ? 161 VAL A CA  1 
ATOM   1307 C  C   . VAL A 1 161 ? -14.79788 24.57311 6.47815   1.000 16.51321 ? 161 VAL A C   1 
ATOM   1308 O  O   . VAL A 1 161 ? -14.80780 25.17613 5.39658   1.000 18.03042 ? 161 VAL A O   1 
ATOM   1309 C  CB  . VAL A 1 161 ? -14.69654 22.11951 5.86969   1.000 16.37369 ? 161 VAL A CB  1 
ATOM   1310 C  CG1 . VAL A 1 161 ? -13.24983 22.09446 6.31518   1.000 15.88397 ? 161 VAL A CG1 1 
ATOM   1311 C  CG2 . VAL A 1 161 ? -15.33514 20.75851 6.09174   1.000 15.62729 ? 161 VAL A CG2 1 
ATOM   1312 N  N   . GLY A 1 162 ? -14.24488 25.06879 7.58134   1.000 15.51861 ? 162 GLY A N   1 
ATOM   1313 C  CA  . GLY A 1 162 ? -13.53613 26.32605 7.53455   1.000 19.56830 ? 162 GLY A CA  1 
ATOM   1314 C  C   . GLY A 1 162 ? -12.18308 26.20583 6.85670   1.000 21.74345 ? 162 GLY A C   1 
ATOM   1315 O  O   . GLY A 1 162 ? -11.63796 25.11725 6.65523   1.000 18.80659 ? 162 GLY A O   1 
ATOM   1316 N  N   . ASP A 1 163 ? -11.63843 27.36385 6.47495   1.000 18.28257 ? 163 ASP A N   1 
ATOM   1317 C  CA  . ASP A 1 163 ? -10.32968 27.38972 5.83538   1.000 17.88455 ? 163 ASP A CA  1 
ATOM   1318 C  C   . ASP A 1 163 ? -9.21386  26.94341 6.78435   1.000 22.20046 ? 163 ASP A C   1 
ATOM   1319 O  O   . ASP A 1 163 ? -8.16182  26.48725 6.31485   1.000 19.09064 ? 163 ASP A O   1 
ATOM   1320 C  CB  . ASP A 1 163 ? -10.06982 28.79254 5.28099   1.000 18.25615 ? 163 ASP A CB  1 
ATOM   1321 C  CG  . ASP A 1 163 ? -10.95854 29.11622 4.08232   1.000 18.75820 ? 163 ASP A CG  1 
ATOM   1322 O  OD1 . ASP A 1 163 ? -11.00857 28.29084 3.14579   1.000 19.08778 ? 163 ASP A OD1 1 
ATOM   1323 O  OD2 . ASP A 1 163 ? -11.60904 30.18540 4.06955   1.000 19.76378 ? 163 ASP A OD2 1 
ATOM   1324 N  N   . ASP A 1 164 ? -9.43795  27.01761 8.10153   1.000 19.39982 ? 164 ASP A N   1 
ATOM   1325 C  CA  . ASP A 1 164 ? -8.51772  26.47021 9.09393   1.000 19.22592 ? 164 ASP A CA  1 
ATOM   1326 C  C   . ASP A 1 164 ? -8.63253  24.95404 9.25097   1.000 24.00541 ? 164 ASP A C   1 
ATOM   1327 O  O   . ASP A 1 164 ? -8.02809  24.39432 10.16951  1.000 20.19927 ? 164 ASP A O   1 
ATOM   1328 C  CB  . ASP A 1 164 ? -8.73169  27.14297 10.45908  1.000 21.51219 ? 164 ASP A CB  1 
ATOM   1329 C  CG  . ASP A 1 164 ? -10.14916 26.95451 11.00786  1.000 28.49665 ? 164 ASP A CG  1 
ATOM   1330 O  OD1 . ASP A 1 164 ? -10.93737 26.18289 10.42325  1.000 27.04988 ? 164 ASP A OD1 1 
ATOM   1331 O  OD2 . ASP A 1 164 ? -10.47947 27.58314 12.04091  1.000 26.73198 ? 164 ASP A OD2 1 
ATOM   1332 N  N   . GLY A 1 165 ? -9.38992  24.27253 8.39735   1.000 19.24399 ? 165 GLY A N   1 
ATOM   1333 C  CA  . GLY A 1 165 ? -9.47821  22.83502 8.48282   1.000 18.28372 ? 165 GLY A CA  1 
ATOM   1334 C  C   . GLY A 1 165 ? -10.35553 22.31350 9.59983   1.000 23.80343 ? 165 GLY A C   1 
ATOM   1335 O  O   . GLY A 1 165 ? -10.45703 21.08912 9.76718   1.000 20.41203 ? 165 GLY A O   1 
ATOM   1336 N  N   . LYS A 1 166 ? -10.98468 23.18733 10.37425  1.000 20.76069 ? 166 LYS A N   1 
ATOM   1337 C  CA  . LYS A 1 166 ? -11.98538 22.75311 11.33717  1.000 26.59094 ? 166 LYS A CA  1 
ATOM   1338 C  C   . LYS A 1 166 ? -13.37848 23.01294 10.76899  1.000 24.45122 ? 166 LYS A C   1 
ATOM   1339 O  O   . LYS A 1 166 ? -13.55652 23.81499 9.84915   1.000 19.43399 ? 166 LYS A O   1 
ATOM   1340 C  CB  . LYS A 1 166 ? -11.82784 23.47413 12.68411  1.000 21.41346 ? 166 LYS A CB  1 
ATOM   1341 C  CG  . LYS A 1 166 ? -10.48030 23.31641 13.38923  1.000 25.20557 ? 166 LYS A CG  1 
ATOM   1342 C  CD  . LYS A 1 166 ? -9.91241  21.90238 13.27691  1.000 36.55069 ? 166 LYS A CD  1 
ATOM   1343 C  CE  . LYS A 1 166 ? -8.36566  21.92645 13.26516  1.000 51.15304 ? 166 LYS A CE  1 
ATOM   1344 N  NZ  . LYS A 1 166 ? -7.72276  21.10070 12.16883  1.000 54.18355 ? 166 LYS A NZ  1 
ATOM   1345 N  N   . LEU A 1 167 ? -14.37284 22.32632 11.32985  1.000 21.88773 ? 167 LEU A N   1 
ATOM   1346 C  CA  . LEU A 1 167 ? -15.74607 22.61635 10.94928  1.000 21.99310 ? 167 LEU A CA  1 
ATOM   1347 C  C   . LEU A 1 167 ? -16.01884 24.09818 11.15999  1.000 23.11854 ? 167 LEU A C   1 
ATOM   1348 O  O   . LEU A 1 167 ? -15.62208 24.67505 12.17648  1.000 20.79895 ? 167 LEU A O   1 
ATOM   1349 C  CB  . LEU A 1 167 ? -16.71348 21.75673 11.75289  1.000 19.48276 ? 167 LEU A CB  1 
ATOM   1350 C  CG  . LEU A 1 167 ? -16.71714 20.33182 11.19382  1.000 24.66292 ? 167 LEU A CG  1 
ATOM   1351 C  CD1 . LEU A 1 167 ? -17.25027 19.33434 12.20394  1.000 26.13149 ? 167 LEU A CD1 1 
ATOM   1352 C  CD2 . LEU A 1 167 ? -17.54461 20.29471 9.92780   1.000 19.36818 ? 167 LEU A CD2 1 
ATOM   1353 N  N   . ARG A 1 168 ? -16.62780 24.73178 10.16334  1.000 18.61341 ? 168 ARG A N   1 
ATOM   1354 C  CA  . ARG A 1 168 ? -16.93994 26.14896 10.27898  1.000 16.26271 ? 168 ARG A CA  1 
ATOM   1355 C  C   . ARG A 1 168 ? -17.94204 26.36723 11.40848  1.000 23.51890 ? 168 ARG A C   1 
ATOM   1356 O  O   . ARG A 1 168 ? -18.95872 25.66750 11.49456  1.000 18.27224 ? 168 ARG A O   1 
ATOM   1357 C  CB  . ARG A 1 168 ? -17.48914 26.66556 8.95324   1.000 14.30425 ? 168 ARG A CB  1 
ATOM   1358 C  CG  . ARG A 1 168 ? -17.89910 28.11046 8.98110   1.000 17.97307 ? 168 ARG A CG  1 
ATOM   1359 C  CD  . ARG A 1 168 ? -18.60026 28.47707 7.68022   1.000 15.42649 ? 168 ARG A CD  1 
ATOM   1360 N  NE  . ARG A 1 168 ? -17.70008 28.39147 6.53830   1.000 18.14958 ? 168 ARG A NE  1 
ATOM   1361 C  CZ  . ARG A 1 168 ? -16.86358 29.36361 6.17965   1.000 20.25105 ? 168 ARG A CZ  1 
ATOM   1362 N  NH1 . ARG A 1 168 ? -16.81024 30.49342 6.89203   1.000 16.11380 ? 168 ARG A NH1 1 
ATOM   1363 N  NH2 . ARG A 1 168 ? -16.08851 29.21297 5.10740   1.000 15.16709 ? 168 ARG A NH2 1 
ATOM   1364 N  N   . ASN A 1 169 ? -17.64422 27.33404 12.28154  1.000 21.28453 ? 169 ASN A N   1 
ATOM   1365 C  CA  . ASN A 1 169 ? -18.40559 27.53743 13.51677  1.000 21.33565 ? 169 ASN A CA  1 
ATOM   1366 C  C   . ASN A 1 169 ? -19.57506 28.49506 13.27914  1.000 21.08228 ? 169 ASN A C   1 
ATOM   1367 O  O   . ASN A 1 169 ? -19.74032 29.51500 13.94663  1.000 18.84593 ? 169 ASN A O   1 
ATOM   1368 C  CB  . ASN A 1 169 ? -17.48701 28.04087 14.62816  1.000 20.46750 ? 169 ASN A CB  1 
ATOM   1369 C  CG  . ASN A 1 169 ? -18.05605 27.79627 16.02908  1.000 23.96321 ? 169 ASN A CG  1 
ATOM   1370 O  OD1 . ASN A 1 169 ? -18.62322 26.74113 16.31663  1.000 28.87465 ? 169 ASN A OD1 1 
ATOM   1371 N  ND2 . ASN A 1 169 ? -17.89519 28.77587 16.90613  1.000 26.83176 ? 169 ASN A ND2 1 
ATOM   1372 N  N   . SER A 1 170 ? -20.39874 28.13870 12.29643  1.000 17.87137 ? 170 SER A N   1 
ATOM   1373 C  CA  . SER A 1 170 ? -21.61437 28.87529 12.01441  1.000 19.77647 ? 170 SER A CA  1 
ATOM   1374 C  C   . SER A 1 170 ? -22.65939 28.59143 13.09084  1.000 15.13476 ? 170 SER A C   1 
ATOM   1375 O  O   . SER A 1 170 ? -22.52671 27.64193 13.86433  1.000 16.97621 ? 170 SER A O   1 
ATOM   1376 C  CB  . SER A 1 170 ? -22.14516 28.48418 10.63359  1.000 16.65941 ? 170 SER A CB  1 
ATOM   1377 O  OG  . SER A 1 170 ? -22.54308 27.12441 10.63595  1.000 21.17756 ? 170 SER A OG  1 
ATOM   1378 N  N   . PRO A 1 171 ? -23.73397 29.38130 13.14067  1.000 18.20346 ? 171 PRO A N   1 
ATOM   1379 C  CA  . PRO A 1 171 ? -24.84980 29.02451 14.03681  1.000 20.82449 ? 171 PRO A CA  1 
ATOM   1380 C  C   . PRO A 1 171 ? -25.35310 27.60119 13.82907  1.000 19.22700 ? 171 PRO A C   1 
ATOM   1381 O  O   . PRO A 1 171 ? -25.69000 26.92955 14.80967  1.000 20.07930 ? 171 PRO A O   1 
ATOM   1382 C  CB  . PRO A 1 171 ? -25.91698 30.07512 13.69747  1.000 21.01018 ? 171 PRO A CB  1 
ATOM   1383 C  CG  . PRO A 1 171 ? -25.14862 31.23700 13.13989  1.000 20.88909 ? 171 PRO A CG  1 
ATOM   1384 C  CD  . PRO A 1 171 ? -23.95103 30.67051 12.45516  1.000 15.90146 ? 171 PRO A CD  1 
ATOM   1385 N  N   . TRP A 1 172 ? -25.39891 27.11307 12.58276  1.000 20.44011 ? 172 TRP A N   1 
ATOM   1386 C  CA  . TRP A 1 172 ? -25.74526 25.71326 12.35018  1.000 15.29729 ? 172 TRP A CA  1 
ATOM   1387 C  C   . TRP A 1 172 ? -24.91550 24.80778 13.24470  1.000 17.35043 ? 172 TRP A C   1 
ATOM   1388 O  O   . TRP A 1 172 ? -25.44721 23.93075 13.93420  1.000 15.80810 ? 172 TRP A O   1 
ATOM   1389 C  CB  . TRP A 1 172 ? -25.52914 25.35119 10.87828  1.000 16.78436 ? 172 TRP A CB  1 
ATOM   1390 C  CG  . TRP A 1 172 ? -26.48285 26.03646 9.95528   1.000 15.65154 ? 172 TRP A CG  1 
ATOM   1391 C  CD1 . TRP A 1 172 ? -26.19843 27.03604 9.07135   1.000 17.93006 ? 172 TRP A CD1 1 
ATOM   1392 C  CD2 . TRP A 1 172 ? -27.88034 25.77740 9.83184   1.000 15.55271 ? 172 TRP A CD2 1 
ATOM   1393 N  NE1 . TRP A 1 172 ? -27.33547 27.42082 8.40750   1.000 15.70749 ? 172 TRP A NE1 1 
ATOM   1394 C  CE2 . TRP A 1 172 ? -28.38440 26.66552 8.85811   1.000 19.80077 ? 172 TRP A CE2 1 
ATOM   1395 C  CE3 . TRP A 1 172 ? -28.76161 24.89148 10.46383  1.000 12.45177 ? 172 TRP A CE3 1 
ATOM   1396 C  CZ2 . TRP A 1 172 ? -29.73071 26.68529 8.49096   1.000 20.21235 ? 172 TRP A CZ2 1 
ATOM   1397 C  CZ3 . TRP A 1 172 ? -30.09000 24.91031 10.10336  1.000 15.96184 ? 172 TRP A CZ3 1 
ATOM   1398 C  CH2 . TRP A 1 172 ? -30.56750 25.80059 9.12394   1.000 20.26415 ? 172 TRP A CH2 1 
ATOM   1399 N  N   . TYR A 1 173 ? -23.60045 25.03485 13.26753  1.000 17.53107 ? 173 TYR A N   1 
ATOM   1400 C  CA  . TYR A 1 173 ? -22.71486 24.17407 14.03819  1.000 19.51843 ? 173 TYR A CA  1 
ATOM   1401 C  C   . TYR A 1 173 ? -22.78735 24.49142 15.52788  1.000 17.16541 ? 173 TYR A C   1 
ATOM   1402 O  O   . TYR A 1 173 ? -22.85567 23.57708 16.34925  1.000 16.72306 ? 173 TYR A O   1 
ATOM   1403 C  CB  . TYR A 1 173 ? -21.28161 24.30370 13.52403  1.000 17.28549 ? 173 TYR A CB  1 
ATOM   1404 C  CG  . TYR A 1 173 ? -20.32863 23.31428 14.14117  1.000 21.09267 ? 173 TYR A CG  1 
ATOM   1405 C  CD1 . TYR A 1 173 ? -20.44351 21.95473 13.87661  1.000 15.62025 ? 173 TYR A CD1 1 
ATOM   1406 C  CD2 . TYR A 1 173 ? -19.31980 23.73535 15.00385  1.000 21.04582 ? 173 TYR A CD2 1 
ATOM   1407 C  CE1 . TYR A 1 173 ? -19.57165 21.04118 14.44692  1.000 20.51298 ? 173 TYR A CE1 1 
ATOM   1408 C  CE2 . TYR A 1 173 ? -18.44356 22.82888 15.57750  1.000 21.15098 ? 173 TYR A CE2 1 
ATOM   1409 C  CZ  . TYR A 1 173 ? -18.57377 21.48539 15.29178  1.000 22.38075 ? 173 TYR A CZ  1 
ATOM   1410 O  OH  . TYR A 1 173 ? -17.70948 20.57802 15.84967  1.000 29.15175 ? 173 TYR A OH  1 
ATOM   1411 N  N   . GLN A 1 174 ? -22.80176 25.77430 15.89856  1.000 19.33401 ? 174 GLN A N   1 
ATOM   1412 C  CA  . GLN A 1 174 ? -22.86180 26.11140 17.31981  1.000 24.65555 ? 174 GLN A CA  1 
ATOM   1413 C  C   . GLN A 1 174 ? -24.11004 25.53591 17.96731  1.000 23.82831 ? 174 GLN A C   1 
ATOM   1414 O  O   . GLN A 1 174 ? -24.06001 25.04310 19.09865  1.000 25.13491 ? 174 GLN A O   1 
ATOM   1415 C  CB  . GLN A 1 174 ? -22.84478 27.62085 17.52692  1.000 27.83870 ? 174 GLN A CB  1 
ATOM   1416 C  CG  . GLN A 1 174 ? -21.58647 28.32040 17.12622  1.000 23.26478 ? 174 GLN A CG  1 
ATOM   1417 C  CD  . GLN A 1 174 ? -21.77584 29.81331 17.19292  1.000 30.03310 ? 174 GLN A CD  1 
ATOM   1418 O  OE1 . GLN A 1 174 ? -22.12521 30.35455 18.24061  1.000 34.69096 ? 174 GLN A OE1 1 
ATOM   1419 N  NE2 . GLN A 1 174 ? -21.58229 30.48831 16.06733  1.000 28.55126 ? 174 GLN A NE2 1 
ATOM   1420 N  N   . ILE A 1 175 ? -25.23557 25.56871 17.25718  1.000 22.72707 ? 175 ILE A N   1 
ATOM   1421 C  CA  . ILE A 1 175 ? -26.49781 25.14846 17.84947  1.000 18.59795 ? 175 ILE A CA  1 
ATOM   1422 C  C   . ILE A 1 175 ? -26.69864 23.64436 17.76222  1.000 22.65026 ? 175 ILE A C   1 
ATOM   1423 O  O   . ILE A 1 175 ? -27.13975 23.02364 18.73112  1.000 27.84280 ? 175 ILE A O   1 
ATOM   1424 C  CB  . ILE A 1 175 ? -27.65198 25.90969 17.19099  1.000 17.78777 ? 175 ILE A CB  1 
ATOM   1425 C  CG1 . ILE A 1 175 ? -27.50995 27.40505 17.50261  1.000 21.22654 ? 175 ILE A CG1 1 
ATOM   1426 C  CG2 . ILE A 1 175 ? -28.96397 25.37741 17.69697  1.000 20.07342 ? 175 ILE A CG2 1 
ATOM   1427 C  CD1 . ILE A 1 175 ? -28.27248 28.30926 16.56456  1.000 19.39055 ? 175 ILE A CD1 1 
ATOM   1428 N  N   . ALA A 1 176 ? -26.36702 23.02041 16.62901  1.000 23.68242 ? 176 ALA A N   1 
ATOM   1429 C  CA  . ALA A 1 176 ? -26.74145 21.63512 16.40189  1.000 19.97528 ? 176 ALA A CA  1 
ATOM   1430 C  C   . ALA A 1 176 ? -25.56729 20.67971 16.33165  1.000 19.59774 ? 176 ALA A C   1 
ATOM   1431 O  O   . ALA A 1 176 ? -25.78904 19.46553 16.33500  1.000 20.75801 ? 176 ALA A O   1 
ATOM   1432 C  CB  . ALA A 1 176 ? -27.55956 21.50912 15.10777  1.000 21.34951 ? 176 ALA A CB  1 
ATOM   1433 N  N   . GLY A 1 177 ? -24.33728 21.18539 16.26466  1.000 20.28247 ? 177 GLY A N   1 
ATOM   1434 C  CA  . GLY A 1 177 ? -23.21089 20.30143 16.09203  1.000 25.39616 ? 177 GLY A CA  1 
ATOM   1435 C  C   . GLY A 1 177 ? -23.15147 19.75911 14.67143  1.000 22.97700 ? 177 GLY A C   1 
ATOM   1436 O  O   . GLY A 1 177 ? -23.70089 20.32587 13.72544  1.000 20.01206 ? 177 GLY A O   1 
ATOM   1437 N  N   . ILE A 1 178 ? -22.47623 18.61711 14.53900  1.000 23.83017 ? 178 ILE A N   1 
ATOM   1438 C  CA  . ILE A 1 178 ? -22.29960 17.99727 13.23170  1.000 23.80943 ? 178 ILE A CA  1 
ATOM   1439 C  C   . ILE A 1 178 ? -23.60746 17.43155 12.68501  1.000 25.02685 ? 178 ILE A C   1 
ATOM   1440 O  O   . ILE A 1 178 ? -23.72117 17.20731 11.47196  1.000 20.93690 ? 178 ILE A O   1 
ATOM   1441 C  CB  . ILE A 1 178 ? -21.20610 16.90740 13.31542  1.000 24.43787 ? 178 ILE A CB  1 
ATOM   1442 C  CG1 . ILE A 1 178 ? -20.74250 16.48838 11.92216  1.000 22.04040 ? 178 ILE A CG1 1 
ATOM   1443 C  CG2 . ILE A 1 178 ? -21.70020 15.68488 14.07575  1.000 26.17634 ? 178 ILE A CG2 1 
ATOM   1444 C  CD1 . ILE A 1 178 ? -19.66392 15.44741 11.94408  1.000 27.35400 ? 178 ILE A CD1 1 
ATOM   1445 N  N   . ASP A 1 179 ? -24.61030 17.20763 13.54339  1.000 20.85370 ? 179 ASP A N   1 
ATOM   1446 C  CA  . ASP A 1 179 ? -25.83776 16.55416 13.09438  1.000 21.31966 ? 179 ASP A CA  1 
ATOM   1447 C  C   . ASP A 1 179 ? -26.59457 17.36971 12.04906  1.000 16.72662 ? 179 ASP A C   1 
ATOM   1448 O  O   . ASP A 1 179 ? -27.37477 16.79202 11.28445  1.000 20.03204 ? 179 ASP A O   1 
ATOM   1449 C  CB  . ASP A 1 179 ? -26.76995 16.27145 14.28183  1.000 22.49100 ? 179 ASP A CB  1 
ATOM   1450 C  CG  . ASP A 1 179 ? -26.31686 15.08165 15.12447  1.000 29.68401 ? 179 ASP A CG  1 
ATOM   1451 O  OD1 . ASP A 1 179 ? -25.52483 14.24538 14.63087  1.000 31.00006 ? 179 ASP A OD1 1 
ATOM   1452 O  OD2 . ASP A 1 179 ? -26.75730 14.98683 16.29278  1.000 32.86404 ? 179 ASP A OD2 1 
ATOM   1453 N  N   . TYR A 1 180 ? -26.40967 18.69307 12.00131  1.000 14.72648 ? 180 TYR A N   1 
ATOM   1454 C  CA  . TYR A 1 180 ? -27.11200 19.45941 10.97633  1.000 15.99179 ? 180 TYR A CA  1 
ATOM   1455 C  C   . TYR A 1 180 ? -26.67547 19.01686 9.58908   1.000 16.36246 ? 180 TYR A C   1 
ATOM   1456 O  O   . TYR A 1 180 ? -27.49129 18.99457 8.65748   1.000 16.39613 ? 180 TYR A O   1 
ATOM   1457 C  CB  . TYR A 1 180 ? -26.91806 20.96948 11.18934  1.000 13.13133 ? 180 TYR A CB  1 
ATOM   1458 C  CG  . TYR A 1 180 ? -25.69842 21.60431 10.53688  1.000 17.66873 ? 180 TYR A CG  1 
ATOM   1459 C  CD1 . TYR A 1 180 ? -24.48760 21.68863 11.21074  1.000 15.70698 ? 180 TYR A CD1 1 
ATOM   1460 C  CD2 . TYR A 1 180 ? -25.77286 22.15425 9.25465   1.000 15.01097 ? 180 TYR A CD2 1 
ATOM   1461 C  CE1 . TYR A 1 180 ? -23.36690 22.28358 10.62480  1.000 16.31681 ? 180 TYR A CE1 1 
ATOM   1462 C  CE2 . TYR A 1 180 ? -24.67327 22.74703 8.66570   1.000 16.64641 ? 180 TYR A CE2 1 
ATOM   1463 C  CZ  . TYR A 1 180 ? -23.47106 22.81256 9.35453   1.000 18.96023 ? 180 TYR A CZ  1 
ATOM   1464 O  OH  . TYR A 1 180 ? -22.38280 23.40608 8.76360   1.000 14.10983 ? 180 TYR A OH  1 
ATOM   1465 N  N   . ILE A 1 181 ? -25.42144 18.58207 9.45308   1.000 16.66294 ? 181 ILE A N   1 
ATOM   1466 C  CA  . ILE A 1 181 ? -24.94375 18.07691 8.16951   1.000 14.46025 ? 181 ILE A CA  1 
ATOM   1467 C  C   . ILE A 1 181 ? -25.58388 16.72921 7.84548   1.000 15.76174 ? 181 ILE A C   1 
ATOM   1468 O  O   . ILE A 1 181 ? -26.05463 16.50140 6.72171   1.000 15.77507 ? 181 ILE A O   1 
ATOM   1469 C  CB  . ILE A 1 181 ? -23.40880 17.98598 8.17102   1.000 18.09014 ? 181 ILE A CB  1 
ATOM   1470 C  CG1 . ILE A 1 181 ? -22.80203 19.38106 8.35187   1.000 16.32500 ? 181 ILE A CG1 1 
ATOM   1471 C  CG2 . ILE A 1 181 ? -22.91443 17.32306 6.86506   1.000 11.99445 ? 181 ILE A CG2 1 
ATOM   1472 C  CD1 . ILE A 1 181 ? -21.29366 19.36683 8.57127   1.000 15.38195 ? 181 ILE A CD1 1 
ATOM   1473 N  N   . LYS A 1 182 ? -25.60635 15.81026 8.81854   1.000 18.05529 ? 182 LYS A N   1 
ATOM   1474 C  CA  . LYS A 1 182 ? -26.21786 14.49838 8.58786   1.000 19.17919 ? 182 LYS A CA  1 
ATOM   1475 C  C   . LYS A 1 182 ? -27.71381 14.61592 8.33045   1.000 17.07821 ? 182 LYS A C   1 
ATOM   1476 O  O   . LYS A 1 182 ? -28.25074 13.93366 7.45008   1.000 19.93887 ? 182 LYS A O   1 
ATOM   1477 C  CB  . LYS A 1 182 ? -25.98692 13.57041 9.78042   1.000 23.17397 ? 182 LYS A CB  1 
ATOM   1478 C  CG  . LYS A 1 182 ? -24.60022 13.61316 10.37631  1.000 22.70258 ? 182 LYS A CG  1 
ATOM   1479 C  CD  . LYS A 1 182 ? -24.50802 12.57369 11.47544  1.000 27.02901 ? 182 LYS A CD  1 
ATOM   1480 C  CE  . LYS A 1 182 ? -23.15722 12.61917 12.15569  1.000 39.45776 ? 182 LYS A CE  1 
ATOM   1481 N  NZ  . LYS A 1 182 ? -22.99531 11.49276 13.11752  1.000 43.67877 ? 182 LYS A NZ  1 
ATOM   1482 N  N   . VAL A 1 183 ? -28.40390 15.46801 9.09770   1.000 15.20647 ? 183 VAL A N   1 
ATOM   1483 C  CA  . VAL A 1 183 ? -29.84587 15.65075 8.92180   1.000 17.36078 ? 183 VAL A CA  1 
ATOM   1484 C  C   . VAL A 1 183 ? -30.15155 16.20429 7.53446   1.000 19.29420 ? 183 VAL A C   1 
ATOM   1485 O  O   . VAL A 1 183 ? -31.12768 15.79311 6.88583   1.000 15.79747 ? 183 VAL A O   1 
ATOM   1486 C  CB  . VAL A 1 183 ? -30.40435 16.56417 10.03104  1.000 18.90679 ? 183 VAL A CB  1 
ATOM   1487 C  CG1 . VAL A 1 183 ? -31.70180 17.23254 9.59874   1.000 14.52212 ? 183 VAL A CG1 1 
ATOM   1488 C  CG2 . VAL A 1 183 ? -30.61459 15.77431 11.30788  1.000 19.04821 ? 183 VAL A CG2 1 
ATOM   1489 N  N   . ALA A 1 184 ? -29.31757 17.13391 7.04849   1.000 14.51944 ? 184 ALA A N   1 
ATOM   1490 C  CA  . ALA A 1 184 ? -29.57104 17.72921 5.73971   1.000 14.21418 ? 184 ALA A CA  1 
ATOM   1491 C  C   . ALA A 1 184 ? -29.52919 16.67518 4.63920   1.000 14.21991 ? 184 ALA A C   1 
ATOM   1492 O  O   . ALA A 1 184 ? -30.43311 16.60019 3.80074   1.000 11.31103 ? 184 ALA A O   1 
ATOM   1493 C  CB  . ALA A 1 184 ? -28.57106 18.85245 5.46345   1.000 10.91725 ? 184 ALA A CB  1 
ATOM   1494 N  N   . PHE A 1 185 ? -28.49117 15.83808 4.63300   1.000 14.39929 ? 185 PHE A N   1 
ATOM   1495 C  CA  . PHE A 1 185 ? -28.39508 14.80842 3.60413   1.000 14.06160 ? 185 PHE A CA  1 
ATOM   1496 C  C   . PHE A 1 185 ? -29.49325 13.75656 3.76150   1.000 15.27379 ? 185 PHE A C   1 
ATOM   1497 O  O   . PHE A 1 185 ? -30.11662 13.34500 2.77216   1.000 15.22007 ? 185 PHE A O   1 
ATOM   1498 C  CB  . PHE A 1 185 ? -27.00324 14.16408 3.64035   1.000 13.86500 ? 185 PHE A CB  1 
ATOM   1499 C  CG  . PHE A 1 185 ? -25.93500 14.98346 2.95675   1.000 13.78555 ? 185 PHE A CG  1 
ATOM   1500 C  CD1 . PHE A 1 185 ? -25.80528 14.96343 1.57240   1.000 14.81529 ? 185 PHE A CD1 1 
ATOM   1501 C  CD2 . PHE A 1 185 ? -25.07942 15.79003 3.69506   1.000 12.20681 ? 185 PHE A CD2 1 
ATOM   1502 C  CE1 . PHE A 1 185 ? -24.82315 15.72310 0.93084   1.000 13.30091 ? 185 PHE A CE1 1 
ATOM   1503 C  CE2 . PHE A 1 185 ? -24.09062 16.55397 3.06750   1.000 15.06019 ? 185 PHE A CE2 1 
ATOM   1504 C  CZ  . PHE A 1 185 ? -23.96117 16.52070 1.68533   1.000 14.64589 ? 185 PHE A CZ  1 
ATOM   1505 N  N   . GLN A 1 186 ? -29.74704 13.30966 4.99510   1.000 15.61583 ? 186 GLN A N   1 
ATOM   1506 C  CA  . GLN A 1 186 ? -30.78953 12.31086 5.21047   1.000 19.63340 ? 186 GLN A CA  1 
ATOM   1507 C  C   . GLN A 1 186 ? -32.14775 12.83795 4.75449   1.000 14.99131 ? 186 GLN A C   1 
ATOM   1508 O  O   . GLN A 1 186 ? -32.91638 12.12234 4.10346   1.000 14.62475 ? 186 GLN A O   1 
ATOM   1509 C  CB  . GLN A 1 186 ? -30.83161 11.89062 6.69045   1.000 17.84507 ? 186 GLN A CB  1 
ATOM   1510 C  CG  . GLN A 1 186 ? -29.56652 11.18579 7.23751   1.000 17.18539 ? 186 GLN A CG  1 
ATOM   1511 C  CD  . GLN A 1 186 ? -29.34801 9.75216  6.70712   1.000 34.06406 ? 186 GLN A CD  1 
ATOM   1512 O  OE1 . GLN A 1 186 ? -30.02511 9.29367  5.77164   1.000 32.40082 ? 186 GLN A OE1 1 
ATOM   1513 N  NE2 . GLN A 1 186 ? -28.39268 9.03687  7.31911   1.000 29.37415 ? 186 GLN A NE2 1 
ATOM   1514 N  N   . ALA A 1 187 ? -32.45078 14.09659 5.06576   1.000 15.76244 ? 187 ALA A N   1 
ATOM   1515 C  CA  . ALA A 1 187 ? -33.73311 14.65782 4.65608   1.000 17.55267 ? 187 ALA A CA  1 
ATOM   1516 C  C   . ALA A 1 187 ? -33.84284 14.70554 3.13941   1.000 17.47779 ? 187 ALA A C   1 
ATOM   1517 O  O   . ALA A 1 187 ? -34.87980 14.34682 2.56835   1.000 17.45900 ? 187 ALA A O   1 
ATOM   1518 C  CB  . ALA A 1 187 ? -33.91875 16.05427 5.25759   1.000 13.67590 ? 187 ALA A CB  1 
ATOM   1519 N  N   . ALA A 1 188 ? -32.78326 15.15787 2.46732   1.000 13.20585 ? 188 ALA A N   1 
ATOM   1520 C  CA  . ALA A 1 188 ? -32.82846 15.25528 1.01281   1.000 17.27489 ? 188 ALA A CA  1 
ATOM   1521 C  C   . ALA A 1 188 ? -33.07978 13.88984 0.38830   1.000 15.36092 ? 188 ALA A C   1 
ATOM   1522 O  O   . ALA A 1 188 ? -33.91691 13.74866 -0.51196  1.000 15.23277 ? 188 ALA A O   1 
ATOM   1523 C  CB  . ALA A 1 188 ? -31.52732 15.86586 0.48455   1.000 9.78760  ? 188 ALA A CB  1 
ATOM   1524 N  N   . ARG A 1 189 ? -32.36134 12.86567 0.86176   1.000 14.53533 ? 189 ARG A N   1 
ATOM   1525 C  CA  . ARG A 1 189 ? -32.54403 11.52052 0.32017   1.000 16.08380 ? 189 ARG A CA  1 
ATOM   1526 C  C   . ARG A 1 189 ? -33.94583 10.99320 0.59582   1.000 15.03509 ? 189 ARG A C   1 
ATOM   1527 O  O   . ARG A 1 189 ? -34.55637 10.35045 -0.26576  1.000 14.66807 ? 189 ARG A O   1 
ATOM   1528 C  CB  . ARG A 1 189 ? -31.51570 10.56050 0.91620   1.000 16.67964 ? 189 ARG A CB  1 
ATOM   1529 C  CG  . ARG A 1 189 ? -31.72736 9.09736  0.47802   1.000 17.48780 ? 189 ARG A CG  1 
ATOM   1530 C  CD  . ARG A 1 189 ? -31.46869 8.94435  -1.02201  1.000 15.40074 ? 189 ARG A CD  1 
ATOM   1531 N  NE  . ARG A 1 189 ? -30.04823 9.06490  -1.33274  1.000 14.93901 ? 189 ARG A NE  1 
ATOM   1532 C  CZ  . ARG A 1 189 ? -29.54870 9.74853  -2.36763  1.000 17.56827 ? 189 ARG A CZ  1 
ATOM   1533 N  NH1 . ARG A 1 189 ? -30.35302 10.38823 -3.20588  1.000 14.59901 ? 189 ARG A NH1 1 
ATOM   1534 N  NH2 . ARG A 1 189 ? -28.23499 9.79415  -2.57070  1.000 14.01998 ? 189 ARG A NH2 1 
ATOM   1535 N  N   . LYS A 1 190 ? -34.46249 11.24319 1.80051   1.000 18.25560 ? 190 LYS A N   1 
ATOM   1536 C  CA  . LYS A 1 190 ? -35.76139 10.69930 2.19251   1.000 17.46998 ? 190 LYS A CA  1 
ATOM   1537 C  C   . LYS A 1 190 ? -36.88215 11.26140 1.32484   1.000 17.32684 ? 190 LYS A C   1 
ATOM   1538 O  O   . LYS A 1 190 ? -37.70242 10.51011 0.78646   1.000 17.79247 ? 190 LYS A O   1 
ATOM   1539 C  CB  . LYS A 1 190 ? -36.01912 10.99601 3.67323   1.000 16.34887 ? 190 LYS A CB  1 
ATOM   1540 C  CG  . LYS A 1 190 ? -37.43474 10.67954 4.15485   1.000 20.86585 ? 190 LYS A CG  1 
ATOM   1541 C  CD  . LYS A 1 190 ? -37.62516 11.08482 5.62077   1.000 22.79074 ? 190 LYS A CD  1 
ATOM   1542 C  CE  . LYS A 1 190 ? -39.02105 10.71111 6.12921   1.000 25.46066 ? 190 LYS A CE  1 
ATOM   1543 N  NZ  . LYS A 1 190 ? -39.21391 11.12648 7.54505   1.000 26.45235 ? 190 LYS A NZ  1 
ATOM   1544 N  N   . TYR A 1 191 ? -36.92692 12.58460 1.16362   1.000 18.99214 ? 191 TYR A N   1 
ATOM   1545 C  CA  . TYR A 1 191 ? -38.00618 13.20237 0.40387   1.000 16.99960 ? 191 TYR A CA  1 
ATOM   1546 C  C   . TYR A 1 191 ? -37.72420 13.26563 -1.08928  1.000 18.85733 ? 191 TYR A C   1 
ATOM   1547 O  O   . TYR A 1 191 ? -38.66020 13.47832 -1.86711  1.000 18.29178 ? 191 TYR A O   1 
ATOM   1548 C  CB  . TYR A 1 191 ? -38.30607 14.60823 0.95233   1.000 15.35320 ? 191 TYR A CB  1 
ATOM   1549 C  CG  . TYR A 1 191 ? -38.78402 14.55075 2.38941   1.000 15.73088 ? 191 TYR A CG  1 
ATOM   1550 C  CD1 . TYR A 1 191 ? -40.01350 13.97566 2.71121   1.000 14.93335 ? 191 TYR A CD1 1 
ATOM   1551 C  CD2 . TYR A 1 191 ? -37.99015 15.01631 3.42361   1.000 13.38445 ? 191 TYR A CD2 1 
ATOM   1552 C  CE1 . TYR A 1 191 ? -40.44420 13.88621 4.02641   1.000 19.58885 ? 191 TYR A CE1 1 
ATOM   1553 C  CE2 . TYR A 1 191 ? -38.40901 14.93356 4.73700   1.000 21.72621 ? 191 TYR A CE2 1 
ATOM   1554 C  CZ  . TYR A 1 191 ? -39.63798 14.36560 5.03566   1.000 24.01297 ? 191 TYR A CZ  1 
ATOM   1555 O  OH  . TYR A 1 191 ? -40.05694 14.28798 6.34781   1.000 26.91262 ? 191 TYR A OH  1 
ATOM   1556 N  N   . GLY A 1 192 ? -36.47793 13.05812 -1.51431  1.000 20.29968 ? 192 GLY A N   1 
ATOM   1557 C  CA  . GLY A 1 192 ? -36.15070 13.13390 -2.92862  1.000 14.47109 ? 192 GLY A CA  1 
ATOM   1558 C  C   . GLY A 1 192 ? -35.97070 11.80065 -3.61848  1.000 19.18555 ? 192 GLY A C   1 
ATOM   1559 O  O   . GLY A 1 192 ? -36.02686 11.72638 -4.85249  1.000 20.38590 ? 192 GLY A O   1 
ATOM   1560 N  N   . GLY A 1 193 ? -35.75585 10.73603 -2.84364  1.000 19.41613 ? 193 GLY A N   1 
ATOM   1561 C  CA  . GLY A 1 193 ? -35.56764 9.42315  -3.42894  1.000 18.39220 ? 193 GLY A CA  1 
ATOM   1562 C  C   . GLY A 1 193 ? -34.12765 9.16627  -3.84288  1.000 23.95676 ? 193 GLY A C   1 
ATOM   1563 O  O   . GLY A 1 193 ? -33.23106 10.00758 -3.71093  1.000 17.94808 ? 193 GLY A O   1 
ATOM   1564 N  N   . ASP A 1 194 ? -33.91434 7.96193  -4.37735  1.000 26.21670 ? 194 ASP A N   1 
ATOM   1565 C  CA  . ASP A 1 194 ? -32.57866 7.47844  -4.70707  1.000 26.35922 ? 194 ASP A CA  1 
ATOM   1566 C  C   . ASP A 1 194 ? -32.03341 8.05397  -6.00508  1.000 24.44473 ? 194 ASP A C   1 
ATOM   1567 O  O   . ASP A 1 194 ? -30.84320 7.88078  -6.28779  1.000 25.00746 ? 194 ASP A O   1 
ATOM   1568 C  CB  . ASP A 1 194 ? -32.58251 5.94711  -4.80507  1.000 27.23889 ? 194 ASP A CB  1 
ATOM   1569 C  CG  . ASP A 1 194 ? -33.07708 5.28128  -3.53267  1.000 33.79288 ? 194 ASP A CG  1 
ATOM   1570 O  OD1 . ASP A 1 194 ? -32.69281 5.72278  -2.43045  1.000 34.54824 ? 194 ASP A OD1 1 
ATOM   1571 O  OD2 . ASP A 1 194 ? -33.86588 4.32081  -3.63741  1.000 44.96762 ? 194 ASP A OD2 1 
ATOM   1572 N  N   . ASN A 1 195 ? -32.86420 8.72499  -6.79562  1.000 25.02927 ? 195 ASN A N   1 
ATOM   1573 C  CA  . ASN A 1 195 ? -32.44606 9.16488  -8.11628  1.000 26.35370 ? 195 ASN A CA  1 
ATOM   1574 C  C   . ASN A 1 195 ? -31.79606 10.54698 -8.12625  1.000 23.43147 ? 195 ASN A C   1 
ATOM   1575 O  O   . ASN A 1 195 ? -31.09760 10.86856 -9.09083  1.000 28.20186 ? 195 ASN A O   1 
ATOM   1576 C  CB  . ASN A 1 195 ? -33.64398 9.15139  -9.06421  1.000 25.06834 ? 195 ASN A CB  1 
ATOM   1577 C  CG  . ASN A 1 195 ? -34.11718 7.74036  -9.38872  1.000 37.13678 ? 195 ASN A CG  1 
ATOM   1578 O  OD1 . ASN A 1 195 ? -33.40184 6.75884  -9.16758  1.000 32.13370 ? 195 ASN A OD1 1 
ATOM   1579 N  ND2 . ASN A 1 195 ? -35.33109 7.63585  -9.92162  1.000 37.06336 ? 195 ASN A ND2 1 
ATOM   1580 N  N   . ILE A 1 196 ? -32.00586 11.38075 -7.09762  1.000 15.57748 ? 196 ILE A N   1 
ATOM   1581 C  CA  . ILE A 1 196 ? -31.30776 12.66016 -7.04944  1.000 16.54075 ? 196 ILE A CA  1 
ATOM   1582 C  C   . ILE A 1 196 ? -29.92535 12.43855 -6.44848  1.000 20.00366 ? 196 ILE A C   1 
ATOM   1583 O  O   . ILE A 1 196 ? -29.69190 11.46519 -5.71392  1.000 16.40147 ? 196 ILE A O   1 
ATOM   1584 C  CB  . ILE A 1 196 ? -32.11142 13.73151 -6.27775  1.000 15.14804 ? 196 ILE A CB  1 
ATOM   1585 C  CG1 . ILE A 1 196 ? -32.35330 13.32411 -4.81842  1.000 12.84446 ? 196 ILE A CG1 1 
ATOM   1586 C  CG2 . ILE A 1 196 ? -33.43031 14.00494 -6.96588  1.000 15.12395 ? 196 ILE A CG2 1 
ATOM   1587 C  CD1 . ILE A 1 196 ? -32.75102 14.49099 -3.93782  1.000 14.06881 ? 196 ILE A CD1 1 
ATOM   1588 N  N   . LYS A 1 197 ? -28.98679 13.32854 -6.79145  1.000 11.56369 ? 197 LYS A N   1 
ATOM   1589 C  CA  . LYS A 1 197 ? -27.58823 13.18194 -6.41010  1.000 13.60743 ? 197 LYS A CA  1 
ATOM   1590 C  C   . LYS A 1 197 ? -27.19246 14.31381 -5.46791  1.000 14.40007 ? 197 LYS A C   1 
ATOM   1591 O  O   . LYS A 1 197 ? -27.48243 15.48607 -5.73557  1.000 15.14293 ? 197 LYS A O   1 
ATOM   1592 C  CB  . LYS A 1 197 ? -26.69596 13.15353 -7.65137  1.000 14.39037 ? 197 LYS A CB  1 
ATOM   1593 C  CG  . LYS A 1 197 ? -27.02905 12.02296 -8.61619  1.000 19.33217 ? 197 LYS A CG  1 
ATOM   1594 C  CD  . LYS A 1 197 ? -26.44070 10.69111 -8.13643  1.000 22.94007 ? 197 LYS A CD  1 
ATOM   1595 C  CE  . LYS A 1 197 ? -27.15038 9.49385  -8.77496  1.000 32.37941 ? 197 LYS A CE  1 
ATOM   1596 N  NZ  . LYS A 1 197 ? -26.57975 8.18400  -8.31399  1.000 31.05705 ? 197 LYS A NZ  1 
ATOM   1597 N  N   . LEU A 1 198 ? -26.53525 13.96155 -4.36661  1.000 15.36758 ? 198 LEU A N   1 
ATOM   1598 C  CA  . LEU A 1 198 ? -26.36435 14.85803 -3.23020  1.000 17.12047 ? 198 LEU A CA  1 
ATOM   1599 C  C   . LEU A 1 198 ? -24.89436 15.22137 -3.06732  1.000 12.86857 ? 198 LEU A C   1 
ATOM   1600 O  O   . LEU A 1 198 ? -24.04426 14.33294 -2.95506  1.000 13.27851 ? 198 LEU A O   1 
ATOM   1601 C  CB  . LEU A 1 198 ? -26.91252 14.21067 -1.95095  1.000 11.14998 ? 198 LEU A CB  1 
ATOM   1602 C  CG  . LEU A 1 198 ? -28.34288 13.65208 -2.05067  1.000 15.91902 ? 198 LEU A CG  1 
ATOM   1603 C  CD1 . LEU A 1 198 ? -28.85323 13.09280 -0.69885  1.000 10.36498 ? 198 LEU A CD1 1 
ATOM   1604 C  CD2 . LEU A 1 198 ? -29.32843 14.70616 -2.61117  1.000 11.99771 ? 198 LEU A CD2 1 
ATOM   1605 N  N   . TYR A 1 199 ? -24.60189 16.52399 -3.03302  1.000 10.93806 ? 199 TYR A N   1 
ATOM   1606 C  CA  . TYR A 1 199 ? -23.22968 17.01732 -3.01115  1.000 11.06088 ? 199 TYR A CA  1 
ATOM   1607 C  C   . TYR A 1 199 ? -22.95556 17.83588 -1.75953  1.000 12.44378 ? 199 TYR A C   1 
ATOM   1608 O  O   . TYR A 1 199 ? -23.84676 18.49151 -1.21372  1.000 10.22764 ? 199 TYR A O   1 
ATOM   1609 C  CB  . TYR A 1 199 ? -22.92132 17.87393 -4.26125  1.000 13.88113 ? 199 TYR A CB  1 
ATOM   1610 C  CG  . TYR A 1 199 ? -22.98935 17.04142 -5.51043  1.000 14.75330 ? 199 TYR A CG  1 
ATOM   1611 C  CD1 . TYR A 1 199 ? -24.22035 16.65020 -6.03014  1.000 10.66580 ? 199 TYR A CD1 1 
ATOM   1612 C  CD2 . TYR A 1 199 ? -21.82629 16.58521 -6.13341  1.000 12.06996 ? 199 TYR A CD2 1 
ATOM   1613 C  CE1 . TYR A 1 199 ? -24.29827 15.83901 -7.14036  1.000 13.15173 ? 199 TYR A CE1 1 
ATOM   1614 C  CE2 . TYR A 1 199 ? -21.89464 15.77333 -7.25167  1.000 12.56946 ? 199 TYR A CE2 1 
ATOM   1615 C  CZ  . TYR A 1 199 ? -23.13474 15.40862 -7.75057  1.000 13.14158 ? 199 TYR A CZ  1 
ATOM   1616 O  OH  . TYR A 1 199 ? -23.22301 14.61547 -8.87042  1.000 12.04591 ? 199 TYR A OH  1 
ATOM   1617 N  N   . MET A 1 200 ? -21.70414 17.77902 -1.31271  1.000 11.71463 ? 200 MET A N   1 
ATOM   1618 C  CA  . MET A 1 200 ? -21.15889 18.72885 -0.35656  1.000 14.35466 ? 200 MET A CA  1 
ATOM   1619 C  C   . MET A 1 200 ? -20.32819 19.72302 -1.15445  1.000 14.69182 ? 200 MET A C   1 
ATOM   1620 O  O   . MET A 1 200 ? -19.47707 19.31947 -1.94935  1.000 13.63653 ? 200 MET A O   1 
ATOM   1621 C  CB  . MET A 1 200 ? -20.30400 18.03087 0.70733   1.000 10.96755 ? 200 MET A CB  1 
ATOM   1622 C  CG  . MET A 1 200 ? -19.67292 18.97959 1.72887   1.000 14.40677 ? 200 MET A CG  1 
ATOM   1623 S  SD  . MET A 1 200 ? -18.72816 18.08540 2.99857   1.000 17.35256 ? 200 MET A SD  1 
ATOM   1624 C  CE  . MET A 1 200 ? -20.03774 17.17168 3.80123   1.000 13.86561 ? 200 MET A CE  1 
ATOM   1625 N  N   . ASN A 1 201 ? -20.58937 21.01269 -0.96045  1.000 12.01848 ? 201 ASN A N   1 
ATOM   1626 C  CA  . ASN A 1 201 ? -20.05224 22.05926 -1.81962  1.000 12.89159 ? 201 ASN A CA  1 
ATOM   1627 C  C   . ASN A 1 201 ? -19.11331 22.96410 -1.02711  1.000 13.00775 ? 201 ASN A C   1 
ATOM   1628 O  O   . ASN A 1 201 ? -19.39548 23.30678 0.12711   1.000 13.51150 ? 201 ASN A O   1 
ATOM   1629 C  CB  . ASN A 1 201 ? -21.21500 22.85603 -2.42906  1.000 13.51540 ? 201 ASN A CB  1 
ATOM   1630 C  CG  . ASN A 1 201 ? -20.76491 23.92918 -3.39103  1.000 12.72268 ? 201 ASN A CG  1 
ATOM   1631 O  OD1 . ASN A 1 201 ? -20.17637 24.92807 -2.98278  1.000 12.53756 ? 201 ASN A OD1 1 
ATOM   1632 N  ND2 . ASN A 1 201 ? -21.09238 23.75944 -4.66860  1.000 8.87502  ? 201 ASN A ND2 1 
ATOM   1633 N  N   . ASP A 1 202 ? -17.98777 23.34684 -1.63969  1.000 12.54422 ? 202 ASP A N   1 
ATOM   1634 C  CA  . ASP A 1 202 ? -17.05096 24.22708 -0.94992  1.000 11.91558 ? 202 ASP A CA  1 
ATOM   1635 C  C   . ASP A 1 202 ? -16.12781 24.90809 -1.95310  1.000 12.21067 ? 202 ASP A C   1 
ATOM   1636 O  O   . ASP A 1 202 ? -16.04595 24.51263 -3.12124  1.000 13.46515 ? 202 ASP A O   1 
ATOM   1637 C  CB  . ASP A 1 202 ? -16.24041 23.46716 0.11003   1.000 9.28047  ? 202 ASP A CB  1 
ATOM   1638 C  CG  . ASP A 1 202 ? -16.13308 24.24242 1.39277   1.000 15.07823 ? 202 ASP A CG  1 
ATOM   1639 O  OD1 . ASP A 1 202 ? -15.92161 25.48162 1.30231   1.000 12.93281 ? 202 ASP A OD1 1 
ATOM   1640 O  OD2 . ASP A 1 202 ? -16.29222 23.63214 2.47691   1.000 13.48803 ? 202 ASP A OD2 1 
ATOM   1641 N  N   . TYR A 1 203 ? -15.46961 25.97125 -1.48993  1.000 11.72642 ? 203 TYR A N   1 
ATOM   1642 C  CA  . TYR A 1 203 ? -14.42843 26.66079 -2.24597  1.000 13.55766 ? 203 TYR A CA  1 
ATOM   1643 C  C   . TYR A 1 203 ? -13.06991 26.27900 -1.68195  1.000 13.68987 ? 203 TYR A C   1 
ATOM   1644 O  O   . TYR A 1 203 ? -12.96309 25.80229 -0.54818  1.000 13.66884 ? 203 TYR A O   1 
ATOM   1645 C  CB  . TYR A 1 203 ? -14.60297 28.18459 -2.19465  1.000 13.77806 ? 203 TYR A CB  1 
ATOM   1646 C  CG  . TYR A 1 203 ? -14.42816 28.76512 -0.80795  1.000 17.61196 ? 203 TYR A CG  1 
ATOM   1647 C  CD1 . TYR A 1 203 ? -15.51279 28.86864 0.07028   1.000 13.11850 ? 203 TYR A CD1 1 
ATOM   1648 C  CD2 . TYR A 1 203 ? -13.17732 29.20099 -0.36677  1.000 16.38239 ? 203 TYR A CD2 1 
ATOM   1649 C  CE1 . TYR A 1 203 ? -15.35219 29.39541 1.35071   1.000 18.14638 ? 203 TYR A CE1 1 
ATOM   1650 C  CE2 . TYR A 1 203 ? -13.00453 29.72246 0.91541   1.000 14.64139 ? 203 TYR A CE2 1 
ATOM   1651 C  CZ  . TYR A 1 203 ? -14.09070 29.81677 1.76704   1.000 19.39122 ? 203 TYR A CZ  1 
ATOM   1652 O  OH  . TYR A 1 203 ? -13.91423 30.32684 3.03534   1.000 16.45527 ? 203 TYR A OH  1 
ATOM   1653 N  N   . ASN A 1 204 ? -12.02446 26.49849 -2.48579  1.000 15.42242 ? 204 ASN A N   1 
ATOM   1654 C  CA  . ASN A 1 204 ? -10.65415 26.19717 -2.06417  1.000 17.13498 ? 204 ASN A CA  1 
ATOM   1655 C  C   . ASN A 1 204 ? -10.53207 24.73657 -1.63920  1.000 16.37712 ? 204 ASN A C   1 
ATOM   1656 O  O   . ASN A 1 204 ? -9.81668  24.39600 -0.68996  1.000 15.85549 ? 204 ASN A O   1 
ATOM   1657 C  CB  . ASN A 1 204 ? -10.19915 27.12683 -0.93515  1.000 15.16708 ? 204 ASN A CB  1 
ATOM   1658 C  CG  . ASN A 1 204 ? -9.83603  28.51228 -1.43105  1.000 21.70011 ? 204 ASN A CG  1 
ATOM   1659 O  OD1 . ASN A 1 204 ? -10.03831 28.83716 -2.60096  1.000 19.72915 ? 204 ASN A OD1 1 
ATOM   1660 N  ND2 . ASN A 1 204 ? -9.29630  29.33990 -0.53812  1.000 21.82429 ? 204 ASN A ND2 1 
ATOM   1661 N  N   . THR A 1 205 ? -11.25680 23.86289 -2.34472  1.000 13.47119 ? 205 THR A N   1 
ATOM   1662 C  CA  . THR A 1 205 ? -11.20023 22.44153 -2.05158  1.000 12.05163 ? 205 THR A CA  1 
ATOM   1663 C  C   . THR A 1 205 ? -9.81815  21.86177 -2.31927  1.000 17.86581 ? 205 THR A C   1 
ATOM   1664 O  O   . THR A 1 205 ? -9.52581  20.75590 -1.84343  1.000 16.02525 ? 205 THR A O   1 
ATOM   1665 C  CB  . THR A 1 205 ? -12.26749 21.67518 -2.86140  1.000 11.65889 ? 205 THR A CB  1 
ATOM   1666 O  OG1 . THR A 1 205 ? -12.11750 21.94384 -4.25912  1.000 11.79905 ? 205 THR A OG1 1 
ATOM   1667 C  CG2 . THR A 1 205 ? -13.68706 22.07475 -2.42741  1.000 11.25591 ? 205 THR A CG2 1 
ATOM   1668 N  N   . GLU A 1 206 ? -8.96321  22.58805 -3.04289  1.000 12.25203 ? 206 GLU A N   1 
ATOM   1669 C  CA  . GLU A 1 206 ? -7.61723  22.14283 -3.37448  1.000 18.95332 ? 206 GLU A CA  1 
ATOM   1670 C  C   . GLU A 1 206 ? -6.61198  22.43856 -2.27615  1.000 19.72470 ? 206 GLU A C   1 
ATOM   1671 O  O   . GLU A 1 206 ? -5.46800  21.99122 -2.37295  1.000 22.97838 ? 206 GLU A O   1 
ATOM   1672 C  CB  . GLU A 1 206 ? -7.11812  22.82485 -4.66813  1.000 20.00892 ? 206 GLU A CB  1 
ATOM   1673 C  CG  . GLU A 1 206 ? -8.08914  22.85052 -5.87207  1.000 17.36180 ? 206 GLU A CG  1 
ATOM   1674 C  CD  . GLU A 1 206 ? -9.21742  23.87580 -5.74150  1.000 20.71917 ? 206 GLU A CD  1 
ATOM   1675 O  OE1 . GLU A 1 206 ? -9.17412  24.71338 -4.80902  1.000 18.36918 ? 206 GLU A OE1 1 
ATOM   1676 O  OE2 . GLU A 1 206 ? -10.16344 23.84033 -6.57323  1.000 24.20955 ? 206 GLU A OE2 1 
ATOM   1677 N  N   . VAL A 1 207 ? -6.98603  23.20490 -1.25962  1.000 20.58267 ? 207 VAL A N   1 
ATOM   1678 C  CA  . VAL A 1 207 ? -6.02610  23.85276 -0.37980  1.000 16.93681 ? 207 VAL A CA  1 
ATOM   1679 C  C   . VAL A 1 207 ? -6.01044  23.13830 0.95652   1.000 23.15402 ? 207 VAL A C   1 
ATOM   1680 O  O   . VAL A 1 207 ? -7.06246  22.97059 1.59414   1.000 18.93741 ? 207 VAL A O   1 
ATOM   1681 C  CB  . VAL A 1 207 ? -6.35224  25.34233 -0.19215  1.000 18.32281 ? 207 VAL A CB  1 
ATOM   1682 C  CG1 . VAL A 1 207 ? -5.17932  26.04341 0.50406   1.000 19.57206 ? 207 VAL A CG1 1 
ATOM   1683 C  CG2 . VAL A 1 207 ? -6.63685  25.97350 -1.53196  1.000 20.06290 ? 207 VAL A CG2 1 
ATOM   1684 N  N   . GLU A 1 208 ? -4.80369  22.73588 1.39258   1.000 17.16113 ? 208 GLU A N   1 
ATOM   1685 C  CA  . GLU A 1 208 ? -4.69603  22.19784 2.73664   1.000 21.07751 ? 208 GLU A CA  1 
ATOM   1686 C  C   . GLU A 1 208 ? -4.62831  23.34220 3.74712   1.000 17.55367 ? 208 GLU A C   1 
ATOM   1687 O  O   . GLU A 1 208 ? -4.11148  24.41577 3.44166   1.000 19.70907 ? 208 GLU A O   1 
ATOM   1688 C  CB  . GLU A 1 208 ? -3.46887  21.29409 2.85817   1.000 23.04873 ? 208 GLU A CB  1 
ATOM   1689 C  CG  . GLU A 1 208 ? -3.52190  20.04146 1.97310   1.000 17.84432 ? 208 GLU A CG  1 
ATOM   1690 C  CD  . GLU A 1 208 ? -4.61556  19.04494 2.38741   1.000 20.30060 ? 208 GLU A CD  1 
ATOM   1691 O  OE1 . GLU A 1 208 ? -5.28826  19.27257 3.41656   1.000 19.26666 ? 208 GLU A OE1 1 
ATOM   1692 O  OE2 . GLU A 1 208 ? -4.79584  18.02240 1.68367   1.000 18.88430 ? 208 GLU A OE2 1 
ATOM   1693 N  N   . PRO A 1 209 ? -5.15928  23.14710 4.96599   1.000 19.51403 ? 209 PRO A N   1 
ATOM   1694 C  CA  . PRO A 1 209 ? -5.68856  21.88947 5.50628   1.000 18.98448 ? 209 PRO A CA  1 
ATOM   1695 C  C   . PRO A 1 209 ? -7.17606  21.62192 5.20536   1.000 22.02852 ? 209 PRO A C   1 
ATOM   1696 O  O   . PRO A 1 209 ? -7.69305  20.59846 5.66657   1.000 21.15882 ? 209 PRO A O   1 
ATOM   1697 C  CB  . PRO A 1 209 ? -5.46556  22.05810 7.00711   1.000 18.52175 ? 209 PRO A CB  1 
ATOM   1698 C  CG  . PRO A 1 209 ? -5.63382  23.53927 7.23646   1.000 18.04162 ? 209 PRO A CG  1 
ATOM   1699 C  CD  . PRO A 1 209 ? -5.17063  24.22778 5.96660   1.000 15.94269 ? 209 PRO A CD  1 
ATOM   1700 N  N   . LYS A 1 210 ? -7.84310  22.50782 4.45232   1.000 20.52929 ? 210 LYS A N   1 
ATOM   1701 C  CA  . LYS A 1 210 ? -9.25779  22.29575 4.14119   1.000 21.19817 ? 210 LYS A CA  1 
ATOM   1702 C  C   . LYS A 1 210 ? -9.47826  21.01023 3.34844   1.000 18.47302 ? 210 LYS A C   1 
ATOM   1703 O  O   . LYS A 1 210 ? -10.40852 20.25056 3.64033   1.000 14.88483 ? 210 LYS A O   1 
ATOM   1704 C  CB  . LYS A 1 210 ? -9.82169  23.49314 3.37128   1.000 21.88271 ? 210 LYS A CB  1 
ATOM   1705 C  CG  . LYS A 1 210 ? -11.33626 23.44938 3.19102   1.000 18.44379 ? 210 LYS A CG  1 
ATOM   1706 C  CD  . LYS A 1 210 ? -11.83437 24.57393 2.28934   1.000 20.98788 ? 210 LYS A CD  1 
ATOM   1707 C  CE  . LYS A 1 210 ? -12.76592 25.50479 3.04611   1.000 18.37383 ? 210 LYS A CE  1 
ATOM   1708 N  NZ  . LYS A 1 210 ? -13.08927 26.74229 2.29474   1.000 18.73661 ? 210 LYS A NZ  1 
ATOM   1709 N  N   . ARG A 1 211 ? -8.62559  20.74437 2.35261   1.000 15.58510 ? 211 ARG A N   1 
ATOM   1710 C  CA  . ARG A 1 211 ? -8.84159  19.60719 1.45844   1.000 19.25305 ? 211 ARG A CA  1 
ATOM   1711 C  C   . ARG A 1 211 ? -8.96533  18.29358 2.22709   1.000 19.97146 ? 211 ARG A C   1 
ATOM   1712 O  O   . ARG A 1 211 ? -9.90555  17.52286 2.01663   1.000 18.96793 ? 211 ARG A O   1 
ATOM   1713 C  CB  . ARG A 1 211 ? -7.70222  19.50735 0.43561   1.000 17.29912 ? 211 ARG A CB  1 
ATOM   1714 C  CG  . ARG A 1 211 ? -7.76053  18.21592 -0.38742  1.000 16.95024 ? 211 ARG A CG  1 
ATOM   1715 C  CD  . ARG A 1 211 ? -6.78592  18.21672 -1.55286  1.000 16.30695 ? 211 ARG A CD  1 
ATOM   1716 N  NE  . ARG A 1 211 ? -5.39345  18.36182 -1.11802  1.000 20.96587 ? 211 ARG A NE  1 
ATOM   1717 C  CZ  . ARG A 1 211 ? -4.38994  18.68852 -1.93243  1.000 20.92076 ? 211 ARG A CZ  1 
ATOM   1718 N  NH1 . ARG A 1 211 ? -4.63144  18.91364 -3.22203  1.000 15.10201 ? 211 ARG A NH1 1 
ATOM   1719 N  NH2 . ARG A 1 211 ? -3.14598  18.79340 -1.46499  1.000 20.22068 ? 211 ARG A NH2 1 
ATOM   1720 N  N   . THR A 1 212 ? -8.00506  18.00501 3.10367   1.000 19.53654 ? 212 THR A N   1 
ATOM   1721 C  CA  . THR A 1 212 ? -8.03013  16.73888 3.82908   1.000 17.35679 ? 212 THR A CA  1 
ATOM   1722 C  C   . THR A 1 212 ? -9.11475  16.73771 4.90350   1.000 16.32272 ? 212 THR A C   1 
ATOM   1723 O  O   . THR A 1 212 ? -9.67806  15.68419 5.21879   1.000 19.19917 ? 212 THR A O   1 
ATOM   1724 C  CB  . THR A 1 212 ? -6.64162  16.47341 4.42899   1.000 22.78052 ? 212 THR A CB  1 
ATOM   1725 O  OG1 . THR A 1 212 ? -5.70517  16.28060 3.35864   1.000 19.62432 ? 212 THR A OG1 1 
ATOM   1726 C  CG2 . THR A 1 212 ? -6.63352  15.21835 5.32559   1.000 17.35549 ? 212 THR A CG2 1 
ATOM   1727 N  N   . ALA A 1 213 ? -9.43111  17.90626 5.46233   1.000 16.88524 ? 213 ALA A N   1 
ATOM   1728 C  CA  . ALA A 1 213 ? -10.53214 17.99301 6.41607   1.000 22.94020 ? 213 ALA A CA  1 
ATOM   1729 C  C   . ALA A 1 213 ? -11.86211 17.66028 5.74372   1.000 18.26159 ? 213 ALA A C   1 
ATOM   1730 O  O   . ALA A 1 213 ? -12.68652 16.92764 6.30934   1.000 17.11677 ? 213 ALA A O   1 
ATOM   1731 C  CB  . ALA A 1 213 ? -10.56238 19.38646 7.04809   1.000 15.96740 ? 213 ALA A CB  1 
ATOM   1732 N  N   . LEU A 1 214 ? -12.07358 18.16090 4.51884   1.000 20.20619 ? 214 LEU A N   1 
ATOM   1733 C  CA  . LEU A 1 214 ? -13.27036 17.79625 3.75669   1.000 18.53046 ? 214 LEU A CA  1 
ATOM   1734 C  C   . LEU A 1 214 ? -13.29372 16.30801 3.45753   1.000 18.36566 ? 214 LEU A C   1 
ATOM   1735 O  O   . LEU A 1 214 ? -14.31851 15.63679 3.64248   1.000 17.31400 ? 214 LEU A O   1 
ATOM   1736 C  CB  . LEU A 1 214 ? -13.33179 18.57720 2.44666   1.000 14.31714 ? 214 LEU A CB  1 
ATOM   1737 C  CG  . LEU A 1 214 ? -14.03119 19.92132 2.57845   1.000 20.87218 ? 214 LEU A CG  1 
ATOM   1738 C  CD1 . LEU A 1 214 ? -13.62545 20.86889 1.44743   1.000 20.37215 ? 214 LEU A CD1 1 
ATOM   1739 C  CD2 . LEU A 1 214 ? -15.54544 19.70331 2.64058   1.000 21.77915 ? 214 LEU A CD2 1 
ATOM   1740 N  N   . TYR A 1 215 ? -12.17266 15.79065 2.94847   1.000 15.42088 ? 215 TYR A N   1 
ATOM   1741 C  CA  . TYR A 1 215 ? -12.00298 14.35867 2.72512   1.000 16.05201 ? 215 TYR A CA  1 
ATOM   1742 C  C   . TYR A 1 215 ? -12.36181 13.54390 3.96365   1.000 19.52150 ? 215 TYR A C   1 
ATOM   1743 O  O   . TYR A 1 215 ? -13.14599 12.59199 3.88955   1.000 19.50942 ? 215 TYR A O   1 
ATOM   1744 C  CB  . TYR A 1 215 ? -10.55374 14.08365 2.31610   1.000 17.67503 ? 215 TYR A CB  1 
ATOM   1745 C  CG  . TYR A 1 215 ? -10.23201 12.62096 2.10598   1.000 17.12026 ? 215 TYR A CG  1 
ATOM   1746 C  CD1 . TYR A 1 215 ? -10.41744 12.02603 0.86360   1.000 19.09001 ? 215 TYR A CD1 1 
ATOM   1747 C  CD2 . TYR A 1 215 ? -9.74669  11.83298 3.14998   1.000 16.34567 ? 215 TYR A CD2 1 
ATOM   1748 C  CE1 . TYR A 1 215 ? -10.13089 10.69050 0.66418   1.000 20.21969 ? 215 TYR A CE1 1 
ATOM   1749 C  CE2 . TYR A 1 215 ? -9.45093  10.49448 2.95597   1.000 20.81904 ? 215 TYR A CE2 1 
ATOM   1750 C  CZ  . TYR A 1 215 ? -9.64387  9.93226  1.70896   1.000 23.09484 ? 215 TYR A CZ  1 
ATOM   1751 O  OH  . TYR A 1 215 ? -9.36036  8.60405  1.50055   1.000 27.07970 ? 215 TYR A OH  1 
ATOM   1752 N  N   . ASN A 1 216 ? -11.74711 13.86947 5.10551   1.000 16.52771 ? 216 ASN A N   1 
ATOM   1753 C  CA  . ASN A 1 216 ? -11.98285 13.08272 6.30944   1.000 17.87753 ? 216 ASN A CA  1 
ATOM   1754 C  C   . ASN A 1 216 ? -13.44315 13.16264 6.73052   1.000 19.33125 ? 216 ASN A C   1 
ATOM   1755 O  O   . ASN A 1 216 ? -14.04325 12.14980 7.10535   1.000 16.16403 ? 216 ASN A O   1 
ATOM   1756 C  CB  . ASN A 1 216 ? -11.08409 13.56825 7.44555   1.000 18.25679 ? 216 ASN A CB  1 
ATOM   1757 C  CG  . ASN A 1 216 ? -9.62467  13.20340 7.24095   1.000 23.16603 ? 216 ASN A CG  1 
ATOM   1758 O  OD1 . ASN A 1 216 ? -9.29060  12.26565 6.50686   1.000 19.19669 ? 216 ASN A OD1 1 
ATOM   1759 N  ND2 . ASN A 1 216 ? -8.74220  13.95437 7.89287   1.000 20.67654 ? 216 ASN A ND2 1 
ATOM   1760 N  N   . LEU A 1 217 ? -14.03483 14.36002 6.64921   1.000 18.22171 ? 217 LEU A N   1 
ATOM   1761 C  CA  . LEU A 1 217 ? -15.43082 14.53788 7.04192   1.000 19.12399 ? 217 LEU A CA  1 
ATOM   1762 C  C   . LEU A 1 217 ? -16.35343 13.66904 6.20146   1.000 19.51978 ? 217 LEU A C   1 
ATOM   1763 O  O   . LEU A 1 217 ? -17.20366 12.94876 6.73718   1.000 24.17226 ? 217 LEU A O   1 
ATOM   1764 C  CB  . LEU A 1 217 ? -15.82289 16.01223 6.93149   1.000 18.09692 ? 217 LEU A CB  1 
ATOM   1765 C  CG  . LEU A 1 217 ? -17.29056 16.34325 7.21449   1.000 21.93516 ? 217 LEU A CG  1 
ATOM   1766 C  CD1 . LEU A 1 217 ? -17.71026 15.92883 8.63956   1.000 16.28007 ? 217 LEU A CD1 1 
ATOM   1767 C  CD2 . LEU A 1 217 ? -17.55017 17.83883 6.96761   1.000 17.63746 ? 217 LEU A CD2 1 
ATOM   1768 N  N   . VAL A 1 218 ? -16.17701 13.69338 4.87871   1.000 18.11461 ? 218 VAL A N   1 
ATOM   1769 C  CA  . VAL A 1 218 ? -17.08550 12.95594 4.00123   1.000 22.14234 ? 218 VAL A CA  1 
ATOM   1770 C  C   . VAL A 1 218 ? -16.87917 11.45524 4.15906   1.000 20.90243 ? 218 VAL A C   1 
ATOM   1771 O  O   . VAL A 1 218 ? -17.83751 10.67361 4.14218   1.000 17.76309 ? 218 VAL A O   1 
ATOM   1772 C  CB  . VAL A 1 218 ? -16.89502 13.40559 2.53910   1.000 21.23330 ? 218 VAL A CB  1 
ATOM   1773 C  CG1 . VAL A 1 218 ? -17.54690 12.42041 1.59320   1.000 20.01033 ? 218 VAL A CG1 1 
ATOM   1774 C  CG2 . VAL A 1 218 ? -17.46915 14.80326 2.33573   1.000 20.40703 ? 218 VAL A CG2 1 
ATOM   1775 N  N   . LYS A 1 219 ? -15.62199 11.02970 4.29010   1.000 24.81512 ? 219 LYS A N   1 
ATOM   1776 C  CA  . LYS A 1 219 ? -15.32577 9.61627  4.51059   1.000 23.24495 ? 219 LYS A CA  1 
ATOM   1777 C  C   . LYS A 1 219 ? -16.02629 9.10191  5.76319   1.000 23.13045 ? 219 LYS A C   1 
ATOM   1778 O  O   . LYS A 1 219 ? -16.64177 8.02849  5.75103   1.000 22.44646 ? 219 LYS A O   1 
ATOM   1779 C  CB  . LYS A 1 219 ? -13.80852 9.43488  4.61440   1.000 21.70235 ? 219 LYS A CB  1 
ATOM   1780 C  CG  . LYS A 1 219 ? -13.32395 8.00811  4.77638   1.000 26.42547 ? 219 LYS A CG  1 
ATOM   1781 C  CD  . LYS A 1 219 ? -11.79859 7.96760  4.81246   1.000 23.06129 ? 219 LYS A CD  1 
ATOM   1782 C  CE  . LYS A 1 219 ? -11.28651 6.54329  4.65102   1.000 25.93357 ? 219 LYS A CE  1 
ATOM   1783 N  NZ  . LYS A 1 219 ? -11.72054 5.71295  5.80846   1.000 34.10362 ? 219 LYS A NZ  1 
ATOM   1784 N  N   . GLN A 1 220 ? -15.96669 9.87452  6.84741   1.000 19.70320 ? 220 GLN A N   1 
ATOM   1785 C  CA  . GLN A 1 220 ? -16.59595 9.45051  8.08772   1.000 26.48203 ? 220 GLN A CA  1 
ATOM   1786 C  C   . GLN A 1 220 ? -18.11426 9.44917  7.96515   1.000 25.86129 ? 220 GLN A C   1 
ATOM   1787 O  O   . GLN A 1 220 ? -18.77722 8.51268  8.42933   1.000 25.26377 ? 220 GLN A O   1 
ATOM   1788 C  CB  . GLN A 1 220 ? -16.13907 10.35338 9.22991   1.000 23.38191 ? 220 GLN A CB  1 
ATOM   1789 C  CG  . GLN A 1 220 ? -16.90701 10.15073 10.52548  1.000 37.22686 ? 220 GLN A CG  1 
ATOM   1790 C  CD  . GLN A 1 220 ? -16.56852 11.21026 11.55322  1.000 45.70134 ? 220 GLN A CD  1 
ATOM   1791 O  OE1 . GLN A 1 220 ? -15.39910 11.54460 11.74025  1.000 50.81592 ? 220 GLN A OE1 1 
ATOM   1792 N  NE2 . GLN A 1 220 ? -17.59226 11.75901 12.21452  1.000 44.01082 ? 220 GLN A NE2 1 
ATOM   1793 N  N   . LEU A 1 221 ? -18.68499 10.48151 7.33720   1.000 21.87125 ? 221 LEU A N   1 
ATOM   1794 C  CA  . LEU A 1 221 ? -20.14018 10.53793 7.20422   1.000 21.61054 ? 221 LEU A CA  1 
ATOM   1795 C  C   . LEU A 1 221 ? -20.66835 9.36807  6.38747   1.000 23.63280 ? 221 LEU A C   1 
ATOM   1796 O  O   . LEU A 1 221 ? -21.68967 8.76859  6.74300   1.000 24.84263 ? 221 LEU A O   1 
ATOM   1797 C  CB  . LEU A 1 221 ? -20.56580 11.86464 6.58102   1.000 18.78934 ? 221 LEU A CB  1 
ATOM   1798 C  CG  . LEU A 1 221 ? -20.32366 13.05066 7.51036   1.000 22.20402 ? 221 LEU A CG  1 
ATOM   1799 C  CD1 . LEU A 1 221 ? -20.78431 14.34430 6.87856   1.000 20.55338 ? 221 LEU A CD1 1 
ATOM   1800 C  CD2 . LEU A 1 221 ? -21.03344 12.81049 8.83108   1.000 24.37935 ? 221 LEU A CD2 1 
ATOM   1801 N  N   . LYS A 1 222 ? -19.98221 9.02156  5.29289   1.000 21.75123 ? 222 LYS A N   1 
ATOM   1802 C  CA  . LYS A 1 222 ? -20.41127 7.88012  4.49211   1.000 23.71999 ? 222 LYS A CA  1 
ATOM   1803 C  C   . LYS A 1 222 ? -20.24748 6.56730  5.24921   1.000 31.98230 ? 222 LYS A C   1 
ATOM   1804 O  O   . LYS A 1 222 ? -21.03025 5.63056  5.04093   1.000 29.67944 ? 222 LYS A O   1 
ATOM   1805 C  CB  . LYS A 1 222 ? -19.62436 7.82665  3.18341   1.000 28.15413 ? 222 LYS A CB  1 
ATOM   1806 C  CG  . LYS A 1 222 ? -19.89575 8.98709  2.23555   1.000 22.64673 ? 222 LYS A CG  1 
ATOM   1807 C  CD  . LYS A 1 222 ? -19.27559 8.70305  0.87870   1.000 26.74645 ? 222 LYS A CD  1 
ATOM   1808 C  CE  . LYS A 1 222 ? -20.08246 7.67736  0.11422   1.000 23.65834 ? 222 LYS A CE  1 
ATOM   1809 N  NZ  . LYS A 1 222 ? -19.40905 7.34592  -1.16828  1.000 39.27272 ? 222 LYS A NZ  1 
ATOM   1810 N  N   . GLU A 1 223 ? -19.23422 6.46944  6.11665   1.000 26.85019 ? 223 GLU A N   1 
ATOM   1811 C  CA  . GLU A 1 223 ? -19.09141 5.26419  6.92458   1.000 27.33353 ? 223 GLU A CA  1 
ATOM   1812 C  C   . GLU A 1 223 ? -20.25847 5.12503  7.88784   1.000 28.87732 ? 223 GLU A C   1 
ATOM   1813 O  O   . GLU A 1 223 ? -20.70758 4.00887  8.17330   1.000 25.95919 ? 223 GLU A O   1 
ATOM   1814 C  CB  . GLU A 1 223 ? -17.76456 5.28381  7.68228   1.000 24.19194 ? 223 GLU A CB  1 
ATOM   1815 C  CG  . GLU A 1 223 ? -16.59368 4.82878  6.83657   1.000 29.59722 ? 223 GLU A CG  1 
ATOM   1816 C  CD  . GLU A 1 223 ? -15.25630 5.20887  7.43809   1.000 35.13414 ? 223 GLU A CD  1 
ATOM   1817 O  OE1 . GLU A 1 223 ? -15.24124 5.89384  8.48700   1.000 35.46797 ? 223 GLU A OE1 1 
ATOM   1818 O  OE2 . GLU A 1 223 ? -14.21989 4.83875  6.84816   1.000 32.80015 ? 223 GLU A OE2 1 
ATOM   1819 N  N   . GLU A 1 224 ? -20.76580 6.25091  8.39196   1.000 25.89121 ? 224 GLU A N   1 
ATOM   1820 C  CA  . GLU A 1 224 ? -21.96005 6.26221  9.22751   1.000 26.06906 ? 224 GLU A CA  1 
ATOM   1821 C  C   . GLU A 1 224 ? -23.25266 6.16804  8.43228   1.000 25.13320 ? 224 GLU A C   1 
ATOM   1822 O  O   . GLU A 1 224 ? -24.32331 6.28525  9.03287   1.000 31.99421 ? 224 GLU A O   1 
ATOM   1823 C  CB  . GLU A 1 224 ? -22.00975 7.52705  10.07738  1.000 23.40694 ? 224 GLU A CB  1 
ATOM   1824 C  CG  . GLU A 1 224 ? -20.81220 7.74170  10.96604  1.000 25.07618 ? 224 GLU A CG  1 
ATOM   1825 C  CD  . GLU A 1 224 ? -20.92329 9.05170  11.71567  1.000 31.93393 ? 224 GLU A CD  1 
ATOM   1826 O  OE1 . GLU A 1 224 ? -22.01906 9.65597  11.68107  1.000 38.05494 ? 224 GLU A OE1 1 
ATOM   1827 O  OE2 . GLU A 1 224 ? -19.93112 9.47329  12.34245  1.000 33.96571 ? 224 GLU A OE2 1 
ATOM   1828 N  N   . GLY A 1 225 ? -23.18945 5.98989  7.11246   1.000 25.53082 ? 225 GLY A N   1 
ATOM   1829 C  CA  . GLY A 1 225 ? -24.38519 5.79980  6.31485   1.000 29.48117 ? 225 GLY A CA  1 
ATOM   1830 C  C   . GLY A 1 225 ? -25.05323 7.06220  5.81300   1.000 26.84028 ? 225 GLY A C   1 
ATOM   1831 O  O   . GLY A 1 225 ? -26.15045 6.97771  5.25024   1.000 28.47711 ? 225 GLY A O   1 
ATOM   1832 N  N   . VAL A 1 226 ? -24.44517 8.22401  6.00791   1.000 25.25565 ? 226 VAL A N   1 
ATOM   1833 C  CA  . VAL A 1 226 ? -25.01355 9.46898  5.47448   1.000 20.20935 ? 226 VAL A CA  1 
ATOM   1834 C  C   . VAL A 1 226 ? -24.90363 9.44612  3.95297   1.000 19.95660 ? 226 VAL A C   1 
ATOM   1835 O  O   . VAL A 1 226 ? -23.81858 9.15515  3.42094   1.000 21.33235 ? 226 VAL A O   1 
ATOM   1836 C  CB  . VAL A 1 226 ? -24.28806 10.67791 6.07060   1.000 20.28119 ? 226 VAL A CB  1 
ATOM   1837 C  CG1 . VAL A 1 226 ? -24.81715 11.98304 5.48804   1.000 14.10493 ? 226 VAL A CG1 1 
ATOM   1838 C  CG2 . VAL A 1 226 ? -24.43370 10.67944 7.58207   1.000 20.95432 ? 226 VAL A CG2 1 
ATOM   1839 N  N   . PRO A 1 227 ? -25.98289 9.71002  3.20496   1.000 18.16514 ? 227 PRO A N   1 
ATOM   1840 C  CA  . PRO A 1 227 ? -25.91803 9.62744  1.73922   1.000 19.57048 ? 227 PRO A CA  1 
ATOM   1841 C  C   . PRO A 1 227 ? -25.25700 10.86788 1.13098   1.000 16.43022 ? 227 PRO A C   1 
ATOM   1842 O  O   . PRO A 1 227 ? -25.82686 11.96151 1.13704   1.000 21.19190 ? 227 PRO A O   1 
ATOM   1843 C  CB  . PRO A 1 227 ? -27.39254 9.50079  1.33400   1.000 15.57594 ? 227 PRO A CB  1 
ATOM   1844 C  CG  . PRO A 1 227 ? -28.12459 10.23942 2.40891   1.000 14.55853 ? 227 PRO A CG  1 
ATOM   1845 C  CD  . PRO A 1 227 ? -27.33612 10.05811 3.68380   1.000 13.75562 ? 227 PRO A CD  1 
ATOM   1846 N  N   . ILE A 1 228 ? -24.03655 10.69292 0.63011   1.000 13.43936 ? 228 ILE A N   1 
ATOM   1847 C  CA  . ILE A 1 228 ? -23.28697 11.74901 -0.05389  1.000 18.79292 ? 228 ILE A CA  1 
ATOM   1848 C  C   . ILE A 1 228 ? -22.76687 11.16794 -1.36252  1.000 18.60053 ? 228 ILE A C   1 
ATOM   1849 O  O   . ILE A 1 228 ? -22.01391 10.18608 -1.35080  1.000 15.63605 ? 228 ILE A O   1 
ATOM   1850 C  CB  . ILE A 1 228 ? -22.11560 12.28541 0.79258   1.000 15.98365 ? 228 ILE A CB  1 
ATOM   1851 C  CG1 . ILE A 1 228 ? -22.57787 12.65430 2.20060   1.000 18.32533 ? 228 ILE A CG1 1 
ATOM   1852 C  CG2 . ILE A 1 228 ? -21.48297 13.51154 0.12422   1.000 15.97614 ? 228 ILE A CG2 1 
ATOM   1853 C  CD1 . ILE A 1 228 ? -21.43812 13.10882 3.11582   1.000 20.74196 ? 228 ILE A CD1 1 
ATOM   1854 N  N   . ASP A 1 229 ? -23.15595 11.77025 -2.48692  1.000 16.79630 ? 229 ASP A N   1 
ATOM   1855 C  CA  . ASP A 1 229 ? -22.77779 11.23332 -3.79176  1.000 14.00630 ? 229 ASP A CA  1 
ATOM   1856 C  C   . ASP A 1 229 ? -21.57235 11.92406 -4.41551  1.000 14.61243 ? 229 ASP A C   1 
ATOM   1857 O  O   . ASP A 1 229 ? -20.85991 11.30609 -5.21443  1.000 15.08316 ? 229 ASP A O   1 
ATOM   1858 C  CB  . ASP A 1 229 ? -23.96561 11.31918 -4.75872  1.000 14.65020 ? 229 ASP A CB  1 
ATOM   1859 C  CG  . ASP A 1 229 ? -25.16307 10.54089 -4.26261  1.000 18.73341 ? 229 ASP A CG  1 
ATOM   1860 O  OD1 . ASP A 1 229 ? -24.99447 9.33814  -3.95722  1.000 20.18971 ? 229 ASP A OD1 1 
ATOM   1861 O  OD2 . ASP A 1 229 ? -26.26463 11.12861 -4.14517  1.000 16.22897 ? 229 ASP A OD2 1 
ATOM   1862 N  N   . GLY A 1 230 ? -21.32033 13.18317 -4.08809  1.000 10.54891 ? 230 GLY A N   1 
ATOM   1863 C  CA  . GLY A 1 230 ? -20.22421 13.85080 -4.75701  1.000 13.63024 ? 230 GLY A CA  1 
ATOM   1864 C  C   . GLY A 1 230 ? -19.78504 15.09071 -4.01405  1.000 14.76588 ? 230 GLY A C   1 
ATOM   1865 O  O   . GLY A 1 230 ? -20.35570 15.47275 -2.98578  1.000 12.04644 ? 230 GLY A O   1 
ATOM   1866 N  N   . ILE A 1 231 ? -18.74016 15.70690 -4.56022  1.000 12.44258 ? 231 ILE A N   1 
ATOM   1867 C  CA  . ILE A 1 231 ? -18.18322 16.95682 -4.06118  1.000 12.64018 ? 231 ILE A CA  1 
ATOM   1868 C  C   . ILE A 1 231 ? -18.40493 18.03102 -5.11645  1.000 13.60791 ? 231 ILE A C   1 
ATOM   1869 O  O   . ILE A 1 231 ? -18.06782 17.83172 -6.29398  1.000 11.79500 ? 231 ILE A O   1 
ATOM   1870 C  CB  . ILE A 1 231 ? -16.68021 16.82299 -3.74449  1.000 12.84713 ? 231 ILE A CB  1 
ATOM   1871 C  CG1 . ILE A 1 231 ? -16.43793 15.75170 -2.68061  1.000 13.01736 ? 231 ILE A CG1 1 
ATOM   1872 C  CG2 . ILE A 1 231 ? -16.08850 18.19014 -3.33692  1.000 9.23204  ? 231 ILE A CG2 1 
ATOM   1873 C  CD1 . ILE A 1 231 ? -16.97048 16.13952 -1.29851  1.000 14.94335 ? 231 ILE A CD1 1 
ATOM   1874 N  N   . GLY A 1 232 ? -18.95439 19.17119 -4.69404  1.000 12.17933 ? 232 GLY A N   1 
ATOM   1875 C  CA  . GLY A 1 232 ? -19.02775 20.34426 -5.54901  1.000 9.55398  ? 232 GLY A CA  1 
ATOM   1876 C  C   . GLY A 1 232 ? -17.85543 21.27223 -5.31317  1.000 11.06860 ? 232 GLY A C   1 
ATOM   1877 O  O   . GLY A 1 232 ? -17.72926 21.83684 -4.22249  1.000 10.67809 ? 232 GLY A O   1 
ATOM   1878 N  N   . HIS A 1 233 ? -16.98117 21.42730 -6.31683  1.000 8.77998  ? 233 HIS A N   1 
ATOM   1879 C  CA  . HIS A 1 233 ? -15.82532 22.31605 -6.23505  1.000 10.12809 ? 233 HIS A CA  1 
ATOM   1880 C  C   . HIS A 1 233 ? -16.19600 23.65555 -6.86245  1.000 13.21011 ? 233 HIS A C   1 
ATOM   1881 O  O   . HIS A 1 233 ? -16.33696 23.75672 -8.08752  1.000 12.49061 ? 233 HIS A O   1 
ATOM   1882 C  CB  . HIS A 1 233 ? -14.60848 21.72201 -6.95123  1.000 10.56106 ? 233 HIS A CB  1 
ATOM   1883 C  CG  . HIS A 1 233 ? -14.32836 20.29008 -6.60560  1.000 13.42841 ? 233 HIS A CG  1 
ATOM   1884 N  ND1 . HIS A 1 233 ? -13.38404 19.92190 -5.67145  1.000 12.87837 ? 233 HIS A ND1 1 
ATOM   1885 C  CD2 . HIS A 1 233 ? -14.85293 19.13725 -7.08332  1.000 11.19472 ? 233 HIS A CD2 1 
ATOM   1886 C  CE1 . HIS A 1 233 ? -13.34289 18.60476 -5.58377  1.000 10.88031 ? 233 HIS A CE1 1 
ATOM   1887 N  NE2 . HIS A 1 233 ? -14.22407 18.10478 -6.42975  1.000 14.61699 ? 233 HIS A NE2 1 
ATOM   1888 N  N   . GLN A 1 234 ? -16.30660 24.69083 -6.03217  1.000 12.80299 ? 234 GLN A N   1 
ATOM   1889 C  CA  . GLN A 1 234 ? -16.65522 26.00892 -6.55496  1.000 10.10696 ? 234 GLN A CA  1 
ATOM   1890 C  C   . GLN A 1 234 ? -15.65649 26.47207 -7.61183  1.000 12.86626 ? 234 GLN A C   1 
ATOM   1891 O  O   . GLN A 1 234 ? -16.05844 26.96080 -8.67003  1.000 12.71596 ? 234 GLN A O   1 
ATOM   1892 C  CB  . GLN A 1 234 ? -16.75635 27.01273 -5.40773  1.000 11.58938 ? 234 GLN A CB  1 
ATOM   1893 C  CG  . GLN A 1 234 ? -18.03356 26.82736 -4.59742  1.000 11.10957 ? 234 GLN A CG  1 
ATOM   1894 C  CD  . GLN A 1 234 ? -18.18978 27.84971 -3.49400  1.000 15.76299 ? 234 GLN A CD  1 
ATOM   1895 O  OE1 . GLN A 1 234 ? -17.75478 28.98746 -3.63257  1.000 16.58653 ? 234 GLN A OE1 1 
ATOM   1896 N  NE2 . GLN A 1 234 ? -18.82027 27.45126 -2.39234  1.000 11.99775 ? 234 GLN A NE2 1 
ATOM   1897 N  N   . SER A 1 235 ? -14.35075 26.28482 -7.36857  1.000 10.95220 ? 235 SER A N   1 
ATOM   1898 C  CA  . SER A 1 235 ? -13.29107 26.67369 -8.31708  1.000 13.47408 ? 235 SER A CA  1 
ATOM   1899 C  C   . SER A 1 235 ? -13.33854 28.16709 -8.64247  1.000 12.29375 ? 235 SER A C   1 
ATOM   1900 O  O   . SER A 1 235 ? -13.31563 28.57653 -9.80005  1.000 11.94489 ? 235 SER A O   1 
ATOM   1901 C  CB  . SER A 1 235 ? -13.33728 25.84255 -9.60719  1.000 9.91303  ? 235 SER A CB  1 
ATOM   1902 O  OG  . SER A 1 235 ? -13.61170 24.48553 -9.33319  1.000 16.74524 ? 235 SER A OG  1 
ATOM   1903 N  N   . HIS A 1 236 ? -13.40949 28.98971 -7.61276  1.000 9.54417  ? 236 HIS A N   1 
ATOM   1904 C  CA  . HIS A 1 236 ? -13.17844 30.41191 -7.82162  1.000 11.91019 ? 236 HIS A CA  1 
ATOM   1905 C  C   . HIS A 1 236 ? -11.66882 30.59274 -7.77865  1.000 14.87372 ? 236 HIS A C   1 
ATOM   1906 O  O   . HIS A 1 236 ? -11.05719 30.71793 -6.71172  1.000 15.14012 ? 236 HIS A O   1 
ATOM   1907 C  CB  . HIS A 1 236 ? -13.90487 31.24750 -6.77514  1.000 11.85272 ? 236 HIS A CB  1 
ATOM   1908 C  CG  . HIS A 1 236 ? -15.39198 31.11058 -6.83741  1.000 11.67060 ? 236 HIS A CG  1 
ATOM   1909 N  ND1 . HIS A 1 236 ? -16.12685 31.46772 -7.94871  1.000 14.79575 ? 236 HIS A ND1 1 
ATOM   1910 C  CD2 . HIS A 1 236 ? -16.27668 30.61281 -5.94366  1.000 12.06731 ? 236 HIS A CD2 1 
ATOM   1911 C  CE1 . HIS A 1 236 ? -17.40686 31.22199 -7.72325  1.000 15.26034 ? 236 HIS A CE1 1 
ATOM   1912 N  NE2 . HIS A 1 236 ? -17.52442 30.69471 -6.51730  1.000 16.21240 ? 236 HIS A NE2 1 
ATOM   1913 N  N   . ILE A 1 237 ? -11.05982 30.57732 -8.96070  1.000 11.23695 ? 237 ILE A N   1 
ATOM   1914 C  CA  . ILE A 1 237 ? -9.61157  30.46244 -9.06441  1.000 11.78506 ? 237 ILE A CA  1 
ATOM   1915 C  C   . ILE A 1 237 ? -9.00567  31.66319 -9.78401  1.000 11.86520 ? 237 ILE A C   1 
ATOM   1916 O  O   . ILE A 1 237 ? -9.71074  32.59681 -10.19691 1.000 9.88346  ? 237 ILE A O   1 
ATOM   1917 C  CB  . ILE A 1 237 ? -9.22681  29.14303 -9.76408  1.000 16.45793 ? 237 ILE A CB  1 
ATOM   1918 C  CG1 . ILE A 1 237 ? -9.75630  29.11351 -11.20101 1.000 11.13258 ? 237 ILE A CG1 1 
ATOM   1919 C  CG2 . ILE A 1 237 ? -9.76310  27.92739 -8.97448  1.000 8.87214  ? 237 ILE A CG2 1 
ATOM   1920 C  CD1 . ILE A 1 237 ? -9.36486  27.81858 -11.97380 1.000 13.25071 ? 237 ILE A CD1 1 
ATOM   1921 N  N   . GLN A 1 238 ? -7.68733  31.64008 -9.92393  1.000 12.56641 ? 238 GLN A N   1 
ATOM   1922 C  CA  . GLN A 1 238 ? -6.88722  32.70206 -10.51253 1.000 12.21666 ? 238 GLN A CA  1 
ATOM   1923 C  C   . GLN A 1 238 ? -6.14912  32.15858 -11.72649 1.000 16.78101 ? 238 GLN A C   1 
ATOM   1924 O  O   . GLN A 1 238 ? -6.23649  30.97058 -12.05238 1.000 12.65029 ? 238 GLN A O   1 
ATOM   1925 C  CB  . GLN A 1 238 ? -5.89073  33.26662 -9.49390  1.000 10.54125 ? 238 GLN A CB  1 
ATOM   1926 C  CG  . GLN A 1 238 ? -6.55966  33.89032 -8.27169  1.000 14.51425 ? 238 GLN A CG  1 
ATOM   1927 C  CD  . GLN A 1 238 ? -5.57932  34.15145 -7.13841  1.000 16.62012 ? 238 GLN A CD  1 
ATOM   1928 O  OE1 . GLN A 1 238 ? -5.98349  34.37471 -6.00348  1.000 25.48522 ? 238 GLN A OE1 1 
ATOM   1929 N  NE2 . GLN A 1 238 ? -4.28958  34.12788 -7.44706  1.000 16.62792 ? 238 GLN A NE2 1 
ATOM   1930 N  N   . ILE A 1 239 ? -5.39581  33.04931 -12.38013 1.000 13.76753 ? 239 ILE A N   1 
ATOM   1931 C  CA  . ILE A 1 239 ? -4.65144  32.65962 -13.56995 1.000 14.95152 ? 239 ILE A CA  1 
ATOM   1932 C  C   . ILE A 1 239 ? -3.54628  31.67335 -13.20519 1.000 15.38982 ? 239 ILE A C   1 
ATOM   1933 O  O   . ILE A 1 239 ? -3.30062  30.70166 -13.92894 1.000 17.30973 ? 239 ILE A O   1 
ATOM   1934 C  CB  . ILE A 1 239 ? -4.10942  33.91411 -14.28540 1.000 17.01757 ? 239 ILE A CB  1 
ATOM   1935 C  CG1 . ILE A 1 239 ? -5.23745  34.60301 -15.06666 1.000 12.08104 ? 239 ILE A CG1 1 
ATOM   1936 C  CG2 . ILE A 1 239 ? -2.94568  33.56709 -15.20226 1.000 10.89141 ? 239 ILE A CG2 1 
ATOM   1937 C  CD1 . ILE A 1 239 ? -4.84980  35.96334 -15.65570 1.000 8.78839  ? 239 ILE A CD1 1 
ATOM   1938 N  N   . GLY A 1 240 ? -2.89450  31.87760 -12.06652 1.000 15.59279 ? 240 GLY A N   1 
ATOM   1939 C  CA  . GLY A 1 240 ? -1.84090  30.97784 -11.64612 1.000 20.37059 ? 240 GLY A CA  1 
ATOM   1940 C  C   . GLY A 1 240 ? -2.29330  29.99537 -10.58417 1.000 25.86318 ? 240 GLY A C   1 
ATOM   1941 O  O   . GLY A 1 240 ? -1.99386  28.79755 -10.65288 1.000 32.30570 ? 240 GLY A O   1 
ATOM   1942 N  N   . TRP A 1 241 ? -3.04086  30.48313 -9.61439  1.000 19.21851 ? 241 TRP A N   1 
ATOM   1943 C  CA  . TRP A 1 241 ? -3.36200  29.63770 -8.47680  1.000 17.63742 ? 241 TRP A CA  1 
ATOM   1944 C  C   . TRP A 1 241 ? -4.79985  29.15011 -8.56823  1.000 16.83973 ? 241 TRP A C   1 
ATOM   1945 O  O   . TRP A 1 241 ? -5.67458  29.89873 -9.02469  1.000 15.35977 ? 241 TRP A O   1 
ATOM   1946 C  CB  . TRP A 1 241 ? -3.16538  30.42031 -7.17319  1.000 16.18292 ? 241 TRP A CB  1 
ATOM   1947 C  CG  . TRP A 1 241 ? -3.75363  29.75924 -5.96484  1.000 24.11873 ? 241 TRP A CG  1 
ATOM   1948 C  CD1 . TRP A 1 241 ? -3.08643  29.01597 -5.02956  1.000 23.93037 ? 241 TRP A CD1 1 
ATOM   1949 C  CD2 . TRP A 1 241 ? -5.12993  29.78517 -5.54837  1.000 26.14389 ? 241 TRP A CD2 1 
ATOM   1950 N  NE1 . TRP A 1 241 ? -3.96025  28.58012 -4.06298  1.000 30.66313 ? 241 TRP A NE1 1 
ATOM   1951 C  CE2 . TRP A 1 241 ? -5.21989  29.03345 -4.36026  1.000 27.20107 ? 241 TRP A CE2 1 
ATOM   1952 C  CE3 . TRP A 1 241 ? -6.29457  30.36822 -6.06872  1.000 25.42228 ? 241 TRP A CE3 1 
ATOM   1953 C  CZ2 . TRP A 1 241 ? -6.42636  28.84671 -3.68550  1.000 32.45646 ? 241 TRP A CZ2 1 
ATOM   1954 C  CZ3 . TRP A 1 241 ? -7.49469  30.17109 -5.40114  1.000 26.27250 ? 241 TRP A CZ3 1 
ATOM   1955 C  CH2 . TRP A 1 241 ? -7.54813  29.42432 -4.22065  1.000 32.14955 ? 241 TRP A CH2 1 
ATOM   1956 N  N   . PRO A 1 242 ? -5.09427  27.90166 -8.15087  1.000 20.40668 ? 242 PRO A N   1 
ATOM   1957 C  CA  . PRO A 1 242 ? -4.13040  26.86398 -7.76063  1.000 17.23237 ? 242 PRO A CA  1 
ATOM   1958 C  C   . PRO A 1 242 ? -3.55322  26.14069 -8.97797  1.000 16.07592 ? 242 PRO A C   1 
ATOM   1959 O  O   . PRO A 1 242 ? -4.07920  26.25865 -10.08754 1.000 20.57008 ? 242 PRO A O   1 
ATOM   1960 C  CB  . PRO A 1 242 ? -4.96961  25.91213 -6.90470  1.000 17.89399 ? 242 PRO A CB  1 
ATOM   1961 C  CG  . PRO A 1 242 ? -6.32573  26.02300 -7.46498  1.000 23.02399 ? 242 PRO A CG  1 
ATOM   1962 C  CD  . PRO A 1 242 ? -6.47918  27.46973 -7.89770  1.000 19.03650 ? 242 PRO A CD  1 
ATOM   1963 N  N   . SER A 1 243 ? -2.47387  25.39744 -8.77602  1.000 16.51346 ? 243 SER A N   1 
ATOM   1964 C  CA  . SER A 1 243 ? -1.82068  24.72477 -9.88516  1.000 16.70560 ? 243 SER A CA  1 
ATOM   1965 C  C   . SER A 1 243 ? -2.67375  23.57873 -10.40883 1.000 14.96390 ? 243 SER A C   1 
ATOM   1966 O  O   . SER A 1 243 ? -3.44657  22.96093 -9.67334  1.000 15.33525 ? 243 SER A O   1 
ATOM   1967 C  CB  . SER A 1 243 ? -0.46355  24.19289 -9.44487  1.000 15.74851 ? 243 SER A CB  1 
ATOM   1968 O  OG  . SER A 1 243 ? -0.63980  23.05717 -8.61135  1.000 17.07307 ? 243 SER A OG  1 
ATOM   1969 N  N   . GLU A 1 244 ? -2.50026  23.27238 -11.69532 1.000 20.38400 ? 244 GLU A N   1 
ATOM   1970 C  CA  . GLU A 1 244 ? -3.20489  22.13078 -12.26840 1.000 20.56717 ? 244 GLU A CA  1 
ATOM   1971 C  C   . GLU A 1 244 ? -2.86256  20.84524 -11.52129 1.000 20.21247 ? 244 GLU A C   1 
ATOM   1972 O  O   . GLU A 1 244 ? -3.74525  20.01585 -11.26960 1.000 14.98110 ? 244 GLU A O   1 
ATOM   1973 C  CB  . GLU A 1 244 ? -2.88487  21.99543 -13.75854 1.000 16.23502 ? 244 GLU A CB  1 
ATOM   1974 C  CG  . GLU A 1 244 ? -3.59625  23.00241 -14.64118 1.000 18.58798 ? 244 GLU A CG  1 
ATOM   1975 C  CD  . GLU A 1 244 ? -2.77057  24.26344 -14.86904 1.000 23.75682 ? 244 GLU A CD  1 
ATOM   1976 O  OE1 . GLU A 1 244 ? -1.54875  24.14415 -15.11012 1.000 27.15731 ? 244 GLU A OE1 1 
ATOM   1977 O  OE2 . GLU A 1 244 ? -3.33462  25.37446 -14.81565 1.000 19.98629 ? 244 GLU A OE2 1 
ATOM   1978 N  N   . ALA A 1 245 ? -1.59004  20.67916 -11.13103 1.000 19.85894 ? 245 ALA A N   1 
ATOM   1979 C  CA  . ALA A 1 245 ? -1.19614  19.48926 -10.38454 1.000 20.78418 ? 245 ALA A CA  1 
ATOM   1980 C  C   . ALA A 1 245 ? -2.02199  19.34399 -9.11521  1.000 15.18514 ? 245 ALA A C   1 
ATOM   1981 O  O   . ALA A 1 245 ? -2.46454  18.24069 -8.77771  1.000 16.28063 ? 245 ALA A O   1 
ATOM   1982 C  CB  . ALA A 1 245 ? 0.30177   19.53676 -10.04983 1.000 18.10582 ? 245 ALA A CB  1 
ATOM   1983 N  N   . GLU A 1 246 ? -2.23821  20.44839 -8.39615  1.000 15.32255 ? 246 GLU A N   1 
ATOM   1984 C  CA  . GLU A 1 246 ? -3.00054  20.39107 -7.15245  1.000 14.14065 ? 246 GLU A CA  1 
ATOM   1985 C  C   . GLU A 1 246 ? -4.49735  20.21747 -7.40388  1.000 16.60494 ? 246 GLU A C   1 
ATOM   1986 O  O   . GLU A 1 246 ? -5.18650  19.57562 -6.60079  1.000 15.05564 ? 246 GLU A O   1 
ATOM   1987 C  CB  . GLU A 1 246 ? -2.73934  21.64902 -6.32344  1.000 14.85795 ? 246 GLU A CB  1 
ATOM   1988 C  CG  . GLU A 1 246 ? -1.35250  21.68459 -5.68080  1.000 18.81983 ? 246 GLU A CG  1 
ATOM   1989 C  CD  . GLU A 1 246 ? -1.14905  20.58653 -4.64019  1.000 22.75823 ? 246 GLU A CD  1 
ATOM   1990 O  OE1 . GLU A 1 246 ? -2.14035  20.15381 -4.00709  1.000 20.27745 ? 246 GLU A OE1 1 
ATOM   1991 O  OE2 . GLU A 1 246 ? 0.01108   20.14537 -4.46323  1.000 28.76688 ? 246 GLU A OE2 1 
ATOM   1992 N  N   . ILE A 1 247 ? -5.02328  20.76642 -8.50224  1.000 13.85200 ? 247 ILE A N   1 
ATOM   1993 C  CA  . ILE A 1 247 ? -6.40199  20.45481 -8.87630  1.000 14.46830 ? 247 ILE A CA  1 
ATOM   1994 C  C   . ILE A 1 247 ? -6.55093  18.96024 -9.13793  1.000 14.23123 ? 247 ILE A C   1 
ATOM   1995 O  O   . ILE A 1 247 ? -7.50325  18.32087 -8.67261  1.000 13.00131 ? 247 ILE A O   1 
ATOM   1996 C  CB  . ILE A 1 247 ? -6.83500  21.28523 -10.09668 1.000 12.43037 ? 247 ILE A CB  1 
ATOM   1997 C  CG1 . ILE A 1 247 ? -6.91317  22.76798 -9.73420  1.000 13.44813 ? 247 ILE A CG1 1 
ATOM   1998 C  CG2 . ILE A 1 247 ? -8.19309  20.78789 -10.64272 1.000 8.94154  ? 247 ILE A CG2 1 
ATOM   1999 C  CD1 . ILE A 1 247 ? -7.04924  23.66916 -10.94778 1.000 15.48896 ? 247 ILE A CD1 1 
ATOM   2000 N  N   . GLU A 1 248 ? -5.60464  18.38489 -9.88982  1.000 14.04552 ? 248 GLU A N   1 
ATOM   2001 C  CA  . GLU A 1 248 ? -5.66955  16.96885 -10.25331 1.000 14.40885 ? 248 GLU A CA  1 
ATOM   2002 C  C   . GLU A 1 248 ? -5.62047  16.07812 -9.01761  1.000 15.23012 ? 248 GLU A C   1 
ATOM   2003 O  O   . GLU A 1 248 ? -6.40500  15.13176 -8.88079  1.000 15.91039 ? 248 GLU A O   1 
ATOM   2004 C  CB  . GLU A 1 248 ? -4.51524  16.62983 -11.20310 1.000 15.26896 ? 248 GLU A CB  1 
ATOM   2005 C  CG  . GLU A 1 248 ? -4.42143  15.15481 -11.58144 1.000 17.50292 ? 248 GLU A CG  1 
ATOM   2006 C  CD  . GLU A 1 248 ? -3.45111  14.93356 -12.72003 1.000 20.30490 ? 248 GLU A CD  1 
ATOM   2007 O  OE1 . GLU A 1 248 ? -2.49281  15.71995 -12.82410 1.000 25.31824 ? 248 GLU A OE1 1 
ATOM   2008 O  OE2 . GLU A 1 248 ? -3.65176  13.99135 -13.51636 1.000 25.00051 ? 248 GLU A OE2 1 
ATOM   2009 N  N   . LYS A 1 249 ? -4.69076  16.36897 -8.10889  1.000 16.43238 ? 249 LYS A N   1 
ATOM   2010 C  CA  . LYS A 1 249 ? -4.60795  15.62949 -6.85855  1.000 17.12221 ? 249 LYS A CA  1 
ATOM   2011 C  C   . LYS A 1 249 ? -5.91464  15.72506 -6.08158  1.000 17.65439 ? 249 LYS A C   1 
ATOM   2012 O  O   . LYS A 1 249 ? -6.36575  14.74162 -5.48232  1.000 20.34716 ? 249 LYS A O   1 
ATOM   2013 C  CB  . LYS A 1 249 ? -3.42495  16.16625 -6.04250  1.000 16.79446 ? 249 LYS A CB  1 
ATOM   2014 C  CG  . LYS A 1 249 ? -3.32922  15.69750 -4.59035  1.000 19.63880 ? 249 LYS A CG  1 
ATOM   2015 C  CD  . LYS A 1 249 ? -2.04110  16.26295 -3.93917  1.000 25.01223 ? 249 LYS A CD  1 
ATOM   2016 C  CE  . LYS A 1 249 ? -1.65827  15.50878 -2.66755  1.000 26.62870 ? 249 LYS A CE  1 
ATOM   2017 N  NZ  . LYS A 1 249 ? -0.36740  15.98155 -2.09434  1.000 30.86710 ? 249 LYS A NZ  1 
ATOM   2018 N  N   . THR A 1 250 ? -6.54265  16.90187 -6.08283  1.000 17.46184 ? 250 THR A N   1 
ATOM   2019 C  CA  . THR A 1 250 ? -7.80372  17.07027 -5.36226  1.000 17.01062 ? 250 THR A CA  1 
ATOM   2020 C  C   . THR A 1 250 ? -8.89633  16.18855 -5.95574  1.000 14.82965 ? 250 THR A C   1 
ATOM   2021 O  O   . THR A 1 250 ? -9.56888  15.44542 -5.23485  1.000 17.02219 ? 250 THR A O   1 
ATOM   2022 C  CB  . THR A 1 250 ? -8.22260  18.54393 -5.38503  1.000 15.73943 ? 250 THR A CB  1 
ATOM   2023 O  OG1 . THR A 1 250 ? -7.11803  19.34494 -4.94883  1.000 13.97442 ? 250 THR A OG1 1 
ATOM   2024 C  CG2 . THR A 1 250 ? -9.42651  18.79318 -4.45371  1.000 12.55998 ? 250 THR A CG2 1 
ATOM   2025 N  N   . ILE A 1 251 ? -9.07603  16.25076 -7.27822  1.000 14.74340 ? 251 ILE A N   1 
ATOM   2026 C  CA  . ILE A 1 251 ? -10.12577 15.47332 -7.93260  1.000 16.91555 ? 251 ILE A CA  1 
ATOM   2027 C  C   . ILE A 1 251 ? -9.90721  13.98168 -7.69700  1.000 18.89309 ? 251 ILE A C   1 
ATOM   2028 O  O   . ILE A 1 251 ? -10.85052 13.23917 -7.40044  1.000 15.91102 ? 251 ILE A O   1 
ATOM   2029 C  CB  . ILE A 1 251 ? -10.17226 15.80162 -9.43948  1.000 17.72389 ? 251 ILE A CB  1 
ATOM   2030 C  CG1 . ILE A 1 251 ? -10.42526 17.28905 -9.66716  1.000 15.81051 ? 251 ILE A CG1 1 
ATOM   2031 C  CG2 . ILE A 1 251 ? -11.23065 14.97897 -10.13979 1.000 13.83347 ? 251 ILE A CG2 1 
ATOM   2032 C  CD1 . ILE A 1 251 ? -11.82870 17.70249 -9.35591  1.000 14.81967 ? 251 ILE A CD1 1 
ATOM   2033 N  N   . ASN A 1 252 ? -8.66182  13.52107 -7.83981  1.000 13.60254 ? 252 ASN A N   1 
ATOM   2034 C  CA  . ASN A 1 252 ? -8.36970  12.10498 -7.65436  1.000 22.43001 ? 252 ASN A CA  1 
ATOM   2035 C  C   . ASN A 1 252 ? -8.63749  11.66689 -6.22222  1.000 18.64464 ? 252 ASN A C   1 
ATOM   2036 O  O   . ASN A 1 252 ? -9.18478  10.58336 -5.99272  1.000 19.71646 ? 252 ASN A O   1 
ATOM   2037 C  CB  . ASN A 1 252 ? -6.91847  11.81889 -8.03142  1.000 16.87632 ? 252 ASN A CB  1 
ATOM   2038 C  CG  . ASN A 1 252 ? -6.71382  11.80678 -9.50783  1.000 14.05238 ? 252 ASN A CG  1 
ATOM   2039 O  OD1 . ASN A 1 252 ? -7.66236  11.66161 -10.26503 1.000 15.63895 ? 252 ASN A OD1 1 
ATOM   2040 N  ND2 . ASN A 1 252 ? -5.47548  11.95771 -9.93661  1.000 16.64644 ? 252 ASN A ND2 1 
ATOM   2041 N  N   . MET A 1 253 ? -8.25809  12.50099 -5.25294  1.000 18.27479 ? 253 MET A N   1 
ATOM   2042 C  CA  . MET A 1 253 ? -8.47380  12.17371 -3.84795  1.000 16.72784 ? 253 MET A CA  1 
ATOM   2043 C  C   . MET A 1 253 ? -9.94446  11.89435 -3.56745  1.000 22.23612 ? 253 MET A C   1 
ATOM   2044 O  O   . MET A 1 253 ? -10.29359 10.85896 -2.98732  1.000 19.23261 ? 253 MET A O   1 
ATOM   2045 C  CB  . MET A 1 253 ? -7.95308  13.31466 -2.97500  1.000 18.74637 ? 253 MET A CB  1 
ATOM   2046 C  CG  . MET A 1 253 ? -7.81870  12.98538 -1.49796  1.000 14.99680 ? 253 MET A CG  1 
ATOM   2047 S  SD  . MET A 1 253 ? -7.15901  14.38579 -0.57319  1.000 25.99786 ? 253 MET A SD  1 
ATOM   2048 C  CE  . MET A 1 253 ? -5.67941  14.74940 -1.49515  1.000 15.39881 ? 253 MET A CE  1 
ATOM   2049 N  N   . PHE A 1 254 ? -10.83489 12.79231 -3.99597  1.000 22.18006 ? 254 PHE A N   1 
ATOM   2050 C  CA  . PHE A 1 254 ? -12.24780 12.56743 -3.70185  1.000 18.21944 ? 254 PHE A CA  1 
ATOM   2051 C  C   . PHE A 1 254 ? -12.82839 11.44682 -4.55214  1.000 16.68231 ? 254 PHE A C   1 
ATOM   2052 O  O   . PHE A 1 254 ? -13.72487 10.72900 -4.09491  1.000 20.76394 ? 254 PHE A O   1 
ATOM   2053 C  CB  . PHE A 1 254 ? -13.03837 13.86471 -3.87475  1.000 11.69373 ? 254 PHE A CB  1 
ATOM   2054 C  CG  . PHE A 1 254 ? -12.75831 14.86933 -2.79324  1.000 15.53078 ? 254 PHE A CG  1 
ATOM   2055 C  CD1 . PHE A 1 254 ? -13.15881 14.62630 -1.48920  1.000 16.94192 ? 254 PHE A CD1 1 
ATOM   2056 C  CD2 . PHE A 1 254 ? -12.05652 16.03032 -3.07069  1.000 14.51234 ? 254 PHE A CD2 1 
ATOM   2057 C  CE1 . PHE A 1 254 ? -12.89301 15.53624 -0.47871  1.000 14.74706 ? 254 PHE A CE1 1 
ATOM   2058 C  CE2 . PHE A 1 254 ? -11.78349 16.94232 -2.07426  1.000 16.91940 ? 254 PHE A CE2 1 
ATOM   2059 C  CZ  . PHE A 1 254 ? -12.20553 16.69799 -0.77225  1.000 16.17618 ? 254 PHE A CZ  1 
ATOM   2060 N  N   . ALA A 1 255 ? -12.31885 11.25763 -5.76874  1.000 15.03504 ? 255 ALA A N   1 
ATOM   2061 C  CA  . ALA A 1 255 ? -12.78943 10.14983 -6.59771  1.000 20.01336 ? 255 ALA A CA  1 
ATOM   2062 C  C   . ALA A 1 255 ? -12.45674 8.80482  -5.96823  1.000 22.71659 ? 255 ALA A C   1 
ATOM   2063 O  O   . ALA A 1 255 ? -13.15942 7.81503  -6.20895  1.000 20.29460 ? 255 ALA A O   1 
ATOM   2064 C  CB  . ALA A 1 255 ? -12.17930 10.23484 -7.99920  1.000 18.76982 ? 255 ALA A CB  1 
ATOM   2065 N  N   . ALA A 1 256 ? -11.39152 8.74491  -5.16469  1.000 20.04798 ? 256 ALA A N   1 
ATOM   2066 C  CA  . ALA A 1 256 ? -11.02295 7.48265  -4.53591  1.000 24.83785 ? 256 ALA A CA  1 
ATOM   2067 C  C   . ALA A 1 256 ? -12.05441 7.03111  -3.51007  1.000 18.92315 ? 256 ALA A C   1 
ATOM   2068 O  O   . ALA A 1 256 ? -12.14307 5.83308  -3.22949  1.000 21.56725 ? 256 ALA A O   1 
ATOM   2069 C  CB  . ALA A 1 256 ? -9.63834  7.59678  -3.89001  1.000 19.41729 ? 256 ALA A CB  1 
ATOM   2070 N  N   . LEU A 1 257 ? -12.83679 7.95296  -2.95668  1.000 19.31643 ? 257 LEU A N   1 
ATOM   2071 C  CA  . LEU A 1 257 ? -13.94174 7.60648  -2.07497  1.000 16.76346 ? 257 LEU A CA  1 
ATOM   2072 C  C   . LEU A 1 257 ? -15.20193 7.23763  -2.83406  1.000 18.49356 ? 257 LEU A C   1 
ATOM   2073 O  O   . LEU A 1 257 ? -16.26035 7.11311  -2.21697  1.000 22.33298 ? 257 LEU A O   1 
ATOM   2074 C  CB  . LEU A 1 257 ? -14.25018 8.76996  -1.14062  1.000 20.26509 ? 257 LEU A CB  1 
ATOM   2075 C  CG  . LEU A 1 257 ? -13.21264 9.15173  -0.08590  1.000 27.84103 ? 257 LEU A CG  1 
ATOM   2076 C  CD1 . LEU A 1 257 ? -13.68726 10.39409 0.64992   1.000 18.58948 ? 257 LEU A CD1 1 
ATOM   2077 C  CD2 . LEU A 1 257 ? -12.96433 8.01049  0.90149   1.000 20.92569 ? 257 LEU A CD2 1 
ATOM   2078 N  N   . GLY A 1 258 ? -15.12468 7.08700  -4.15416  1.000 17.01230 ? 258 GLY A N   1 
ATOM   2079 C  CA  . GLY A 1 258 ? -16.31015 6.83762  -4.94246  1.000 17.35257 ? 258 GLY A CA  1 
ATOM   2080 C  C   . GLY A 1 258 ? -17.20065 8.04315  -5.14989  1.000 19.86616 ? 258 GLY A C   1 
ATOM   2081 O  O   . GLY A 1 258 ? -18.37083 7.88164  -5.50267  1.000 21.34432 ? 258 GLY A O   1 
ATOM   2082 N  N   . LEU A 1 259 ? -16.68774 9.25022  -4.95704  1.000 16.41342 ? 259 LEU A N   1 
ATOM   2083 C  CA  . LEU A 1 259 ? -17.49958 10.44671 -5.11906  1.000 18.29680 ? 259 LEU A CA  1 
ATOM   2084 C  C   . LEU A 1 259 ? -17.41591 10.98312 -6.54589  1.000 14.77041 ? 259 LEU A C   1 
ATOM   2085 O  O   . LEU A 1 259 ? -16.34833 10.99785 -7.15515  1.000 16.25392 ? 259 LEU A O   1 
ATOM   2086 C  CB  . LEU A 1 259 ? -17.05364 11.52652 -4.13343  1.000 14.76534 ? 259 LEU A CB  1 
ATOM   2087 C  CG  . LEU A 1 259 ? -17.23060 11.20895 -2.64618  1.000 19.64592 ? 259 LEU A CG  1 
ATOM   2088 C  CD1 . LEU A 1 259 ? -16.22492 12.00535 -1.80094  1.000 16.90078 ? 259 LEU A CD1 1 
ATOM   2089 C  CD2 . LEU A 1 259 ? -18.65255 11.50902 -2.21652  1.000 17.26790 ? 259 LEU A CD2 1 
ATOM   2090 N  N   . ASP A 1 260 ? -18.55693 11.41653 -7.07254  1.000 16.40615 ? 260 ASP A N   1 
ATOM   2091 C  CA  . ASP A 1 260 ? -18.58358 12.27857 -8.24493  1.000 13.77915 ? 260 ASP A CA  1 
ATOM   2092 C  C   . ASP A 1 260 ? -17.94043 13.62531 -7.90166  1.000 11.75757 ? 260 ASP A C   1 
ATOM   2093 O  O   . ASP A 1 260 ? -17.88368 14.03226 -6.74109  1.000 11.63338 ? 260 ASP A O   1 
ATOM   2094 C  CB  . ASP A 1 260 ? -20.03073 12.46530 -8.71380  1.000 16.32205 ? 260 ASP A CB  1 
ATOM   2095 C  CG  . ASP A 1 260 ? -20.14045 13.21547 -10.03401 1.000 19.56077 ? 260 ASP A CG  1 
ATOM   2096 O  OD1 . ASP A 1 260 ? -19.25784 13.04024 -10.89863 1.000 14.14304 ? 260 ASP A OD1 1 
ATOM   2097 O  OD2 . ASP A 1 260 ? -21.12426 13.97116 -10.19931 1.000 14.53279 ? 260 ASP A OD2 1 
ATOM   2098 N  N   . ASN A 1 261 ? -17.42293 14.30673 -8.91958  1.000 11.08582 ? 261 ASN A N   1 
ATOM   2099 C  CA  . ASN A 1 261 ? -16.92352 15.66940 -8.77333  1.000 10.10853 ? 261 ASN A CA  1 
ATOM   2100 C  C   . ASN A 1 261 ? -17.64607 16.57296 -9.75942  1.000 14.24200 ? 261 ASN A C   1 
ATOM   2101 O  O   . ASN A 1 261 ? -17.76620 16.23673 -10.94390 1.000 13.01527 ? 261 ASN A O   1 
ATOM   2102 C  CB  . ASN A 1 261 ? -15.41694 15.76214 -9.01480  1.000 11.10446 ? 261 ASN A CB  1 
ATOM   2103 C  CG  . ASN A 1 261 ? -14.61844 14.95015 -8.01870  1.000 13.39193 ? 261 ASN A CG  1 
ATOM   2104 O  OD1 . ASN A 1 261 ? -14.28011 15.43363 -6.93903  1.000 12.50047 ? 261 ASN A OD1 1 
ATOM   2105 N  ND2 . ASN A 1 261 ? -14.30344 13.71046 -8.38114  1.000 11.34538 ? 261 ASN A ND2 1 
ATOM   2106 N  N   . GLN A 1 262 ? -18.12009 17.71651 -9.27344  1.000 11.10204 ? 262 GLN A N   1 
ATOM   2107 C  CA  . GLN A 1 262 ? -18.66754 18.73675 -10.14634 1.000 9.76393  ? 262 GLN A CA  1 
ATOM   2108 C  C   . GLN A 1 262 ? -17.94948 20.04724 -9.87232  1.000 11.82049 ? 262 GLN A C   1 
ATOM   2109 O  O   . GLN A 1 262 ? -17.66564 20.38691 -8.71877  1.000 11.73455 ? 262 GLN A O   1 
ATOM   2110 C  CB  . GLN A 1 262 ? -20.18594 18.87752 -9.97245  1.000 10.35126 ? 262 GLN A CB  1 
ATOM   2111 C  CG  . GLN A 1 262 ? -20.95795 17.63352 -10.41725 1.000 10.24087 ? 262 GLN A CG  1 
ATOM   2112 C  CD  . GLN A 1 262 ? -22.46991 17.83699 -10.48037 1.000 13.17974 ? 262 GLN A CD  1 
ATOM   2113 O  OE1 . GLN A 1 262 ? -23.06238 18.48702 -9.61614  1.000 14.57602 ? 262 GLN A OE1 1 
ATOM   2114 N  NE2 . GLN A 1 262 ? -23.10125 17.26780 -11.50447 1.000 10.77577 ? 262 GLN A NE2 1 
ATOM   2115 N  N   . ILE A 1 263 ? -17.59706 20.73431 -10.95243 1.000 9.90420  ? 263 ILE A N   1 
ATOM   2116 C  CA  . ILE A 1 263 ? -17.05344 22.08434 -10.90547 1.000 11.03593 ? 263 ILE A CA  1 
ATOM   2117 C  C   . ILE A 1 263 ? -18.25807 23.01213 -10.96761 1.000 10.03195 ? 263 ILE A C   1 
ATOM   2118 O  O   . ILE A 1 263 ? -18.90744 23.10720 -12.01040 1.000 12.57742 ? 263 ILE A O   1 
ATOM   2119 C  CB  . ILE A 1 263 ? -16.09567 22.33625 -12.07777 1.000 9.33691  ? 263 ILE A CB  1 
ATOM   2120 C  CG1 . ILE A 1 263 ? -15.10075 21.16973 -12.26664 1.000 14.33745 ? 263 ILE A CG1 1 
ATOM   2121 C  CG2 . ILE A 1 263 ? -15.39171 23.69268 -11.93674 1.000 12.77323 ? 263 ILE A CG2 1 
ATOM   2122 C  CD1 . ILE A 1 263 ? -14.25496 20.82129 -11.02877 1.000 12.50738 ? 263 ILE A CD1 1 
ATOM   2123 N  N   . THR A 1 264 ? -18.58983 23.67202 -9.85607  1.000 8.89552  ? 264 THR A N   1 
ATOM   2124 C  CA  . THR A 1 264 ? -19.90200 24.30065 -9.76714  1.000 11.22403 ? 264 THR A CA  1 
ATOM   2125 C  C   . THR A 1 264 ? -19.88892 25.81622 -9.90293  1.000 10.96640 ? 264 THR A C   1 
ATOM   2126 O  O   . THR A 1 264 ? -20.96009 26.39564 -10.08342 1.000 12.95513 ? 264 THR A O   1 
ATOM   2127 C  CB  . THR A 1 264 ? -20.59569 23.94988 -8.44320  1.000 11.59975 ? 264 THR A CB  1 
ATOM   2128 O  OG1 . THR A 1 264 ? -19.87826 24.54868 -7.35735  1.000 12.06842 ? 264 THR A OG1 1 
ATOM   2129 C  CG2 . THR A 1 264 ? -20.66210 22.44438 -8.24733  1.000 13.76514 ? 264 THR A CG2 1 
ATOM   2130 N  N   . GLY A 1 265 ? -18.73754 26.47762 -9.80409  1.000 10.43654 ? 265 GLY A N   1 
ATOM   2131 C  CA  . GLY A 1 265 ? -18.73841 27.93241 -9.87915  1.000 10.54220 ? 265 GLY A CA  1 
ATOM   2132 C  C   . GLY A 1 265 ? -17.51031 28.49061 -10.56884 1.000 9.39766  ? 265 GLY A C   1 
ATOM   2133 O  O   . GLY A 1 265 ? -16.93930 29.50164 -10.13989 1.000 9.89345  ? 265 GLY A O   1 
ATOM   2134 N  N   . LEU A 1 266 ? -17.07679 27.82968 -11.62899 1.000 8.06715  ? 266 LEU A N   1 
ATOM   2135 C  CA  . LEU A 1 266 ? -15.79321 28.17386 -12.22691 1.000 8.66602  ? 266 LEU A CA  1 
ATOM   2136 C  C   . LEU A 1 266 ? -15.77086 29.62251 -12.70915 1.000 8.40253  ? 266 LEU A C   1 
ATOM   2137 O  O   . LEU A 1 266 ? -16.66272 30.07054 -13.43821 1.000 7.50029  ? 266 LEU A O   1 
ATOM   2138 C  CB  . LEU A 1 266 ? -15.48786 27.23095 -13.38515 1.000 8.55638  ? 266 LEU A CB  1 
ATOM   2139 C  CG  . LEU A 1 266 ? -14.24097 27.56027 -14.20916 1.000 11.00571 ? 266 LEU A CG  1 
ATOM   2140 C  CD1 . LEU A 1 266 ? -13.00107 27.51697 -13.35053 1.000 4.95529  ? 266 LEU A CD1 1 
ATOM   2141 C  CD2 . LEU A 1 266 ? -14.12507 26.59202 -15.38562 1.000 8.42208  ? 266 LEU A CD2 1 
ATOM   2142 N  N   . ASP A 1 267 ? -14.75929 30.36326 -12.26896 1.000 8.31634  ? 267 ASP A N   1 
ATOM   2143 C  CA  . ASP A 1 267 ? -14.37780 31.61292 -12.91537 1.000 8.73307  ? 267 ASP A CA  1 
ATOM   2144 C  C   . ASP A 1 267 ? -12.87395 31.78313 -12.73338 1.000 10.05829 ? 267 ASP A C   1 
ATOM   2145 O  O   . ASP A 1 267 ? -12.30312 31.35460 -11.72687 1.000 8.80159  ? 267 ASP A O   1 
ATOM   2146 C  CB  . ASP A 1 267 ? -15.18344 32.83352 -12.39555 1.000 9.57869  ? 267 ASP A CB  1 
ATOM   2147 C  CG  . ASP A 1 267 ? -15.49823 32.78041 -10.89341 1.000 10.54410 ? 267 ASP A CG  1 
ATOM   2148 O  OD1 . ASP A 1 267 ? -14.69224 32.25629 -10.09763 1.000 12.73549 ? 267 ASP A OD1 1 
ATOM   2149 O  OD2 . ASP A 1 267 ? -16.58529 33.25457 -10.50717 1.000 11.75369 ? 267 ASP A OD2 1 
ATOM   2150 N  N   . VAL A 1 268 ? -12.22530 32.35449 -13.73680 1.000 9.54244  ? 268 VAL A N   1 
ATOM   2151 C  CA  . VAL A 1 268 ? -10.78252 32.56179 -13.70429 1.000 9.85042  ? 268 VAL A CA  1 
ATOM   2152 C  C   . VAL A 1 268 ? -10.57267 34.06604 -13.59544 1.000 11.05682 ? 268 VAL A C   1 
ATOM   2153 O  O   . VAL A 1 268 ? -10.55800 34.77344 -14.61200 1.000 8.96949  ? 268 VAL A O   1 
ATOM   2154 C  CB  . VAL A 1 268 ? -10.08845 31.96614 -14.93752 1.000 11.37332 ? 268 VAL A CB  1 
ATOM   2155 C  CG1 . VAL A 1 268 ? -8.54445  32.21965 -14.87785 1.000 12.64278 ? 268 VAL A CG1 1 
ATOM   2156 C  CG2 . VAL A 1 268 ? -10.39227 30.47033 -15.05970 1.000 7.28703  ? 268 VAL A CG2 1 
ATOM   2157 N  N   . SER A 1 269 ? -10.43492 34.56155 -12.36135 1.000 11.07903 ? 269 SER A N   1 
ATOM   2158 C  CA  . SER A 1 269 ? -10.21032 35.98567 -12.13762 1.000 11.09016 ? 269 SER A CA  1 
ATOM   2159 C  C   . SER A 1 269 ? -8.93551  36.46877 -12.82056 1.000 11.95226 ? 269 SER A C   1 
ATOM   2160 O  O   . SER A 1 269 ? -7.95512  35.72555 -12.98112 1.000 11.49928 ? 269 SER A O   1 
ATOM   2161 C  CB  . SER A 1 269 ? -10.10753 36.29526 -10.64236 1.000 10.75774 ? 269 SER A CB  1 
ATOM   2162 O  OG  . SER A 1 269 ? -9.97446  37.69486 -10.45665 1.000 15.25084 ? 269 SER A OG  1 
ATOM   2163 N  N   . MET A 1 270 ? -8.94896  37.74887 -13.19544 1.000 11.77848 ? 270 MET A N   1 
ATOM   2164 C  CA  . MET A 1 270 ? -7.75440  38.38771 -13.72415 1.000 9.24817  ? 270 MET A CA  1 
ATOM   2165 C  C   . MET A 1 270 ? -6.77347  38.78917 -12.63603 1.000 14.45920 ? 270 MET A C   1 
ATOM   2166 O  O   . MET A 1 270 ? -5.64975  39.17873 -12.96397 1.000 12.55994 ? 270 MET A O   1 
ATOM   2167 C  CB  . MET A 1 270 ? -8.12039  39.63167 -14.53932 1.000 12.36532 ? 270 MET A CB  1 
ATOM   2168 C  CG  . MET A 1 270 ? -8.80076  39.35663 -15.86938 1.000 11.27230 ? 270 MET A CG  1 
ATOM   2169 S  SD  . MET A 1 270 ? -7.74134  38.35678 -16.93891 1.000 13.26971 ? 270 MET A SD  1 
ATOM   2170 C  CE  . MET A 1 270 ? -8.64534  38.48367 -18.48723 1.000 11.53062 ? 270 MET A CE  1 
ATOM   2171 N  N   . TYR A 1 271 ? -7.15642  38.68620 -11.36382 1.000 11.13429 ? 271 TYR A N   1 
ATOM   2172 C  CA  . TYR A 1 271 ? -6.41781  39.29370 -10.26854 1.000 13.72225 ? 271 TYR A CA  1 
ATOM   2173 C  C   . TYR A 1 271 ? -5.97033  38.25561 -9.24858  1.000 13.64651 ? 271 TYR A C   1 
ATOM   2174 O  O   . TYR A 1 271 ? -6.31006  37.06958 -9.32873  1.000 16.30550 ? 271 TYR A O   1 
ATOM   2175 C  CB  . TYR A 1 271 ? -7.26600  40.38143 -9.59117  1.000 12.86110 ? 271 TYR A CB  1 
ATOM   2176 C  CG  . TYR A 1 271 ? -7.84918  41.31622 -10.60955 1.000 11.84873 ? 271 TYR A CG  1 
ATOM   2177 C  CD1 . TYR A 1 271 ? -7.02177  41.99424 -11.49269 1.000 12.34488 ? 271 TYR A CD1 1 
ATOM   2178 C  CD2 . TYR A 1 271 ? -9.21889  41.48540 -10.73001 1.000 10.25075 ? 271 TYR A CD2 1 
ATOM   2179 C  CE1 . TYR A 1 271 ? -7.53380  42.84064 -12.45949 1.000 11.12285 ? 271 TYR A CE1 1 
ATOM   2180 C  CE2 . TYR A 1 271 ? -9.74936  42.33689 -11.69831 1.000 13.66382 ? 271 TYR A CE2 1 
ATOM   2181 C  CZ  . TYR A 1 271 ? -8.89550  43.00710 -12.56133 1.000 13.35612 ? 271 TYR A CZ  1 
ATOM   2182 O  OH  . TYR A 1 271 ? -9.39287  43.85792 -13.51497 1.000 12.47704 ? 271 TYR A OH  1 
ATOM   2183 N  N   . GLY A 1 272 ? -5.16792  38.72512 -8.29994  1.000 15.13479 ? 272 GLY A N   1 
ATOM   2184 C  CA  . GLY A 1 272 ? -4.75233  37.94257 -7.15698  1.000 16.31201 ? 272 GLY A CA  1 
ATOM   2185 C  C   . GLY A 1 272 ? -5.73829  38.05943 -6.01592  1.000 18.96404 ? 272 GLY A C   1 
ATOM   2186 O  O   . GLY A 1 272 ? -6.93746  38.27660 -6.21571  1.000 17.35562 ? 272 GLY A O   1 
ATOM   2187 N  N   . TRP A 1 273 ? -5.22698  37.92937 -4.79491  1.000 21.08159 ? 273 TRP A N   1 
ATOM   2188 C  CA  . TRP A 1 273 ? -6.09365  38.06389 -3.63213  1.000 23.19773 ? 273 TRP A CA  1 
ATOM   2189 C  C   . TRP A 1 273 ? -5.31065  38.66191 -2.47151  1.000 24.06013 ? 273 TRP A C   1 
ATOM   2190 O  O   . TRP A 1 273 ? -4.26437  38.12227 -2.08914  1.000 24.86551 ? 273 TRP A O   1 
ATOM   2191 C  CB  . TRP A 1 273 ? -6.69571  36.71999 -3.22503  1.000 17.09193 ? 273 TRP A CB  1 
ATOM   2192 C  CG  . TRP A 1 273 ? -7.66794  36.86655 -2.09538  1.000 27.49467 ? 273 TRP A CG  1 
ATOM   2193 C  CD1 . TRP A 1 273 ? -7.40946  36.70577 -0.76345  1.000 30.29195 ? 273 TRP A CD1 1 
ATOM   2194 C  CD2 . TRP A 1 273 ? -9.05735  37.22486 -2.19347  1.000 23.95133 ? 273 TRP A CD2 1 
ATOM   2195 N  NE1 . TRP A 1 273 ? -8.55912  36.92832 -0.02763  1.000 31.51038 ? 273 TRP A NE1 1 
ATOM   2196 C  CE2 . TRP A 1 273 ? -9.57981  37.24748 -0.88189  1.000 27.81279 ? 273 TRP A CE2 1 
ATOM   2197 C  CE3 . TRP A 1 273 ? -9.90889  37.52538 -3.26186  1.000 22.99350 ? 273 TRP A CE3 1 
ATOM   2198 C  CZ2 . TRP A 1 273 ? -10.91482 37.56003 -0.61144  1.000 31.44102 ? 273 TRP A CZ2 1 
ATOM   2199 C  CZ3 . TRP A 1 273 ? -11.24532 37.83390 -2.98739  1.000 22.62237 ? 273 TRP A CZ3 1 
ATOM   2200 C  CH2 . TRP A 1 273 ? -11.72806 37.84736 -1.67588  1.000 22.00617 ? 273 TRP A CH2 1 
ATOM   2201 N  N   . PRO A 1 274 ? -5.77548  39.77730 -1.88584  1.000 21.48392 ? 274 PRO A N   1 
ATOM   2202 C  CA  . PRO A 1 274 ? -6.98044  40.50572 -2.30031  1.000 18.67540 ? 274 PRO A CA  1 
ATOM   2203 C  C   . PRO A 1 274 ? -6.79586  41.18468 -3.65914  1.000 17.43945 ? 274 PRO A C   1 
ATOM   2204 O  O   . PRO A 1 274 ? -5.68546  41.59699 -3.98624  1.000 14.95226 ? 274 PRO A O   1 
ATOM   2205 C  CB  . PRO A 1 274 ? -7.16603  41.54804 -1.18793  1.000 19.16972 ? 274 PRO A CB  1 
ATOM   2206 C  CG  . PRO A 1 274 ? -6.24801  41.11426 -0.07198  1.000 19.61946 ? 274 PRO A CG  1 
ATOM   2207 C  CD  . PRO A 1 274 ? -5.11873  40.41714 -0.73274  1.000 20.33950 ? 274 PRO A CD  1 
ATOM   2208 N  N   . PRO A 1 275 ? -7.86134  41.27229 -4.45070  1.000 16.78529 ? 275 PRO A N   1 
ATOM   2209 C  CA  . PRO A 1 275 ? -7.71005  41.77405 -5.82229  1.000 16.45269 ? 275 PRO A CA  1 
ATOM   2210 C  C   . PRO A 1 275 ? -7.41540  43.26998 -5.86062  1.000 15.69645 ? 275 PRO A C   1 
ATOM   2211 O  O   . PRO A 1 275 ? -8.00682  44.06558 -5.12504  1.000 11.27974 ? 275 PRO A O   1 
ATOM   2212 C  CB  . PRO A 1 275 ? -9.06673  41.45862 -6.47425  1.000 16.30894 ? 275 PRO A CB  1 
ATOM   2213 C  CG  . PRO A 1 275 ? -9.80746  40.58730 -5.50173  1.000 16.68138 ? 275 PRO A CG  1 
ATOM   2214 C  CD  . PRO A 1 275 ? -9.25599  40.91608 -4.14638  1.000 15.76297 ? 275 PRO A CD  1 
ATOM   2215 N  N   . ARG A 1 276 ? -6.50344  43.64783 -6.74780  1.000 15.22017 ? 276 ARG A N   1 
ATOM   2216 C  CA  . ARG A 1 276 ? -6.30834  45.04681 -7.12474  1.000 15.43519 ? 276 ARG A CA  1 
ATOM   2217 C  C   . ARG A 1 276 ? -6.77042  45.15466 -8.57874  1.000 13.45007 ? 276 ARG A C   1 
ATOM   2218 O  O   . ARG A 1 276 ? -6.00822  44.89401 -9.50774  1.000 9.63578  ? 276 ARG A O   1 
ATOM   2219 C  CB  . ARG A 1 276 ? -4.86045  45.47237 -6.94969  1.000 14.96827 ? 276 ARG A CB  1 
ATOM   2220 C  CG  . ARG A 1 276 ? -4.34762  45.29025 -5.52359  1.000 17.37774 ? 276 ARG A CG  1 
ATOM   2221 C  CD  . ARG A 1 276 ? -3.05054  46.06781 -5.25016  1.000 18.32318 ? 276 ARG A CD  1 
ATOM   2222 N  NE  . ARG A 1 276 ? -2.76075  46.07344 -3.81473  1.000 22.51697 ? 276 ARG A NE  1 
ATOM   2223 C  CZ  . ARG A 1 276 ? -1.80899  46.79766 -3.22803  1.000 19.78805 ? 276 ARG A CZ  1 
ATOM   2224 N  NH1 . ARG A 1 276 ? -1.01534  47.58765 -3.94246  1.000 18.59594 ? 276 ARG A NH1 1 
ATOM   2225 N  NH2 . ARG A 1 276 ? -1.65720  46.72862 -1.91537  1.000 20.26991 ? 276 ARG A NH2 1 
ATOM   2226 N  N   . ALA A 1 277 ? -8.02014  45.55945 -8.76573  1.000 10.44762 ? 277 ALA A N   1 
ATOM   2227 C  CA  . ALA A 1 277 ? -8.66785  45.51112 -10.06609 1.000 12.92958 ? 277 ALA A CA  1 
ATOM   2228 C  C   . ALA A 1 277 ? -8.40186  46.76160 -10.89349 1.000 16.61176 ? 277 ALA A C   1 
ATOM   2229 O  O   . ALA A 1 277 ? -8.17407  47.85585 -10.36488 1.000 17.19296 ? 277 ALA A O   1 
ATOM   2230 C  CB  . ALA A 1 277 ? -10.17764 45.34355 -9.90025  1.000 8.62182  ? 277 ALA A CB  1 
ATOM   2231 N  N   . TYR A 1 278 ? -8.45803  46.58960 -12.20759 1.000 12.95092 ? 278 TYR A N   1 
ATOM   2232 C  CA  . TYR A 1 278 ? -8.61490  47.72946 -13.09173 1.000 14.41622 ? 278 TYR A CA  1 
ATOM   2233 C  C   . TYR A 1 278 ? -10.02071 48.31833 -12.93765 1.000 15.32722 ? 278 TYR A C   1 
ATOM   2234 O  O   . TYR A 1 278 ? -10.96230 47.61129 -12.56661 1.000 12.67716 ? 278 TYR A O   1 
ATOM   2235 C  CB  . TYR A 1 278 ? -8.37250  47.31258 -14.54058 1.000 13.70873 ? 278 TYR A CB  1 
ATOM   2236 C  CG  . TYR A 1 278 ? -6.92541  46.98002 -14.82512 1.000 16.88532 ? 278 TYR A CG  1 
ATOM   2237 C  CD1 . TYR A 1 278 ? -5.97879  47.98878 -15.01248 1.000 16.22298 ? 278 TYR A CD1 1 
ATOM   2238 C  CD2 . TYR A 1 278 ? -6.49920  45.65899 -14.89105 1.000 12.82987 ? 278 TYR A CD2 1 
ATOM   2239 C  CE1 . TYR A 1 278 ? -4.63876  47.68010 -15.27268 1.000 15.09111 ? 278 TYR A CE1 1 
ATOM   2240 C  CE2 . TYR A 1 278 ? -5.17880  45.34660 -15.14129 1.000 14.56382 ? 278 TYR A CE2 1 
ATOM   2241 C  CZ  . TYR A 1 278 ? -4.25351  46.35916 -15.33063 1.000 14.83893 ? 278 TYR A CZ  1 
ATOM   2242 O  OH  . TYR A 1 278 ? -2.94616  46.03221 -15.57078 1.000 17.02489 ? 278 TYR A OH  1 
ATOM   2243 N  N   . PRO A 1 279 ? -10.19203 49.62593 -13.21021 1.000 14.06823 ? 279 PRO A N   1 
ATOM   2244 C  CA  . PRO A 1 279 ? -11.49134 50.25920 -12.95801 1.000 10.74605 ? 279 PRO A CA  1 
ATOM   2245 C  C   . PRO A 1 279 ? -12.55369 49.93969 -13.99974 1.000 14.43306 ? 279 PRO A C   1 
ATOM   2246 O  O   . PRO A 1 279 ? -13.75367 50.02815 -13.71680 1.000 17.09340 ? 279 PRO A O   1 
ATOM   2247 C  CB  . PRO A 1 279 ? -11.14633 51.75887 -12.95691 1.000 13.06831 ? 279 PRO A CB  1 
ATOM   2248 C  CG  . PRO A 1 279 ? -9.97615  51.87285 -13.85199 1.000 12.94912 ? 279 PRO A CG  1 
ATOM   2249 C  CD  . PRO A 1 279 ? -9.16782  50.61384 -13.59690 1.000 15.08000 ? 279 PRO A CD  1 
ATOM   2250 N  N   . THR A 1 280 ? -12.14017 49.61181 -15.21673 1.000 11.95481 ? 280 THR A N   1 
ATOM   2251 C  CA  . THR A 1 280 ? -13.07976 49.27293 -16.27851 1.000 14.18003 ? 280 THR A CA  1 
ATOM   2252 C  C   . THR A 1 280 ? -12.54348 48.07809 -17.04765 1.000 14.33273 ? 280 THR A C   1 
ATOM   2253 O  O   . THR A 1 280 ? -11.34712 47.77828 -17.01366 1.000 13.13433 ? 280 THR A O   1 
ATOM   2254 C  CB  . THR A 1 280 ? -13.27885 50.40992 -17.28541 1.000 14.31312 ? 280 THR A CB  1 
ATOM   2255 O  OG1 . THR A 1 280 ? -12.04549 50.61675 -17.97235 1.000 14.78996 ? 280 THR A OG1 1 
ATOM   2256 C  CG2 . THR A 1 280 ? -13.67990 51.71138 -16.59045 1.000 16.97680 ? 280 THR A CG2 1 
ATOM   2257 N  N   . TYR A 1 281 ? -13.43943 47.43702 -17.79905 1.000 16.03050 ? 281 TYR A N   1 
ATOM   2258 C  CA  . TYR A 1 281 ? -13.02946 46.35889 -18.69350 1.000 14.77083 ? 281 TYR A CA  1 
ATOM   2259 C  C   . TYR A 1 281 ? -11.99762 46.83295 -19.70674 1.000 14.60400 ? 281 TYR A C   1 
ATOM   2260 O  O   . TYR A 1 281 ? -11.07054 46.09133 -20.06254 1.000 12.85233 ? 281 TYR A O   1 
ATOM   2261 C  CB  . TYR A 1 281 ? -14.25039 45.80734 -19.42035 1.000 15.36494 ? 281 TYR A CB  1 
ATOM   2262 C  CG  . TYR A 1 281 ? -14.04471 44.44883 -20.02222 1.000 15.55072 ? 281 TYR A CG  1 
ATOM   2263 C  CD1 . TYR A 1 281 ? -13.58591 44.30078 -21.32755 1.000 12.63732 ? 281 TYR A CD1 1 
ATOM   2264 C  CD2 . TYR A 1 281 ? -14.32431 43.30278 -19.28042 1.000 15.23680 ? 281 TYR A CD2 1 
ATOM   2265 C  CE1 . TYR A 1 281 ? -13.41289 43.03278 -21.87474 1.000 14.26123 ? 281 TYR A CE1 1 
ATOM   2266 C  CE2 . TYR A 1 281 ? -14.15146 42.05003 -19.81056 1.000 12.24765 ? 281 TYR A CE2 1 
ATOM   2267 C  CZ  . TYR A 1 281 ? -13.70135 41.91215 -21.10004 1.000 12.15699 ? 281 TYR A CZ  1 
ATOM   2268 O  OH  . TYR A 1 281 ? -13.55662 40.63271 -21.59522 1.000 10.50280 ? 281 TYR A OH  1 
ATOM   2269 N  N   . ASP A 1 282 ? -12.17371 48.05016 -20.21564 1.000 13.63069 ? 282 ASP A N   1 
ATOM   2270 C  CA  . ASP A 1 282 ? -11.33397 48.55091 -21.29583 1.000 18.14530 ? 282 ASP A CA  1 
ATOM   2271 C  C   . ASP A 1 282 ? -9.89837  48.77497 -20.84433 1.000 19.38223 ? 282 ASP A C   1 
ATOM   2272 O  O   . ASP A 1 282 ? -8.97634  48.72073 -21.66773 1.000 14.87831 ? 282 ASP A O   1 
ATOM   2273 C  CB  . ASP A 1 282 ? -11.92830 49.84802 -21.84854 1.000 15.09777 ? 282 ASP A CB  1 
ATOM   2274 C  CG  . ASP A 1 282 ? -13.29351 49.62818 -22.47617 1.000 21.10431 ? 282 ASP A CG  1 
ATOM   2275 O  OD1 . ASP A 1 282 ? -13.57444 48.48544 -22.91306 1.000 24.19595 ? 282 ASP A OD1 1 
ATOM   2276 O  OD2 . ASP A 1 282 ? -14.07496 50.58405 -22.54795 1.000 24.83078 ? 282 ASP A OD2 1 
ATOM   2277 N  N   . ALA A 1 283 ? -9.69336  49.03378 -19.55363 1.000 15.81029 ? 283 ALA A N   1 
ATOM   2278 C  CA  . ALA A 1 283 ? -8.35190  49.21582 -19.01640 1.000 16.94023 ? 283 ALA A CA  1 
ATOM   2279 C  C   . ALA A 1 283 ? -7.56995  47.91023 -18.87517 1.000 15.04747 ? 283 ALA A C   1 
ATOM   2280 O  O   . ALA A 1 283 ? -6.36534  47.95812 -18.61567 1.000 13.21531 ? 283 ALA A O   1 
ATOM   2281 C  CB  . ALA A 1 283 ? -8.44034  49.92062 -17.65783 1.000 14.03074 ? 283 ALA A CB  1 
ATOM   2282 N  N   . ILE A 1 284 ? -8.20572  46.74940 -19.02545 1.000 15.68375 ? 284 ILE A N   1 
ATOM   2283 C  CA  . ILE A 1 284 ? -7.49634  45.48506 -18.81825 1.000 16.78195 ? 284 ILE A CA  1 
ATOM   2284 C  C   . ILE A 1 284 ? -6.57493  45.25415 -20.01132 1.000 16.38354 ? 284 ILE A C   1 
ATOM   2285 O  O   . ILE A 1 284 ? -7.05443  45.22758 -21.15244 1.000 19.25909 ? 284 ILE A O   1 
ATOM   2286 C  CB  . ILE A 1 284 ? -8.46711  44.30657 -18.61875 1.000 13.58514 ? 284 ILE A CB  1 
ATOM   2287 C  CG1 . ILE A 1 284 ? -9.44630  44.58809 -17.47428 1.000 14.95385 ? 284 ILE A CG1 1 
ATOM   2288 C  CG2 . ILE A 1 284 ? -7.68809  43.04079 -18.31280 1.000 16.48866 ? 284 ILE A CG2 1 
ATOM   2289 C  CD1 . ILE A 1 284 ? -10.40617 43.43000 -17.17648 1.000 13.75404 ? 284 ILE A CD1 1 
ATOM   2290 N  N   . PRO A 1 285 ? -5.26332  45.09855 -19.81035 1.000 13.24743 ? 285 PRO A N   1 
ATOM   2291 C  CA  . PRO A 1 285 ? -4.36317  44.91301 -20.95349 1.000 16.25878 ? 285 PRO A CA  1 
ATOM   2292 C  C   . PRO A 1 285 ? -4.64114  43.60875 -21.68077 1.000 18.76471 ? 285 PRO A C   1 
ATOM   2293 O  O   . PRO A 1 285 ? -5.00662  42.60168 -21.06963 1.000 12.86746 ? 285 PRO A O   1 
ATOM   2294 C  CB  . PRO A 1 285 ? -2.96493  44.89658 -20.31781 1.000 14.51597 ? 285 PRO A CB  1 
ATOM   2295 C  CG  . PRO A 1 285 ? -3.13548  45.46571 -18.93730 1.000 18.87692 ? 285 PRO A CG  1 
ATOM   2296 C  CD  . PRO A 1 285 ? -4.53273  45.11541 -18.52974 1.000 15.98289 ? 285 PRO A CD  1 
ATOM   2297 N  N   . LYS A 1 286 ? -4.43609  43.64476 -23.00683 1.000 17.63031 ? 286 LYS A N   1 
ATOM   2298 C  CA  . LYS A 1 286 ? -4.62369  42.46784 -23.86033 1.000 20.22507 ? 286 LYS A CA  1 
ATOM   2299 C  C   . LYS A 1 286 ? -3.88726  41.24042 -23.33082 1.000 19.85410 ? 286 LYS A C   1 
ATOM   2300 O  O   . LYS A 1 286 ? -4.37686  40.11042 -23.45533 1.000 17.63875 ? 286 LYS A O   1 
ATOM   2301 C  CB  . LYS A 1 286 ? -4.13981  42.76280 -25.28763 1.000 21.93670 ? 286 LYS A CB  1 
ATOM   2302 C  CG  . LYS A 1 286 ? -4.96277  43.78625 -26.05256 1.000 29.40203 ? 286 LYS A CG  1 
ATOM   2303 C  CD  . LYS A 1 286 ? -5.59650  43.17369 -27.31382 1.000 34.50853 ? 286 LYS A CD  1 
ATOM   2304 C  CE  . LYS A 1 286 ? -6.06399  44.24872 -28.29309 1.000 31.74689 ? 286 LYS A CE  1 
ATOM   2305 N  NZ  . LYS A 1 286 ? -5.30104  44.27122 -29.57478 1.000 40.25600 ? 286 LYS A NZ  1 
ATOM   2306 N  N   . GLN A 1 287 ? -2.69113  41.44159 -22.77467 1.000 17.34018 ? 287 GLN A N   1 
ATOM   2307 C  CA  . GLN A 1 287 ? -1.85367  40.31730 -22.36412 1.000 16.65304 ? 287 GLN A CA  1 
ATOM   2308 C  C   . GLN A 1 287 ? -2.52942  39.47249 -21.28609 1.000 18.97818 ? 287 GLN A C   1 
ATOM   2309 O  O   . GLN A 1 287 ? -2.37297  38.24380 -21.26997 1.000 18.41725 ? 287 GLN A O   1 
ATOM   2310 C  CB  . GLN A 1 287 ? -0.49790  40.83895 -21.88276 1.000 16.42458 ? 287 GLN A CB  1 
ATOM   2311 C  CG  . GLN A 1 287 ? 0.46989   39.76504 -21.42349 1.000 15.80371 ? 287 GLN A CG  1 
ATOM   2312 C  CD  . GLN A 1 287 ? 0.85432   38.82737 -22.54935 1.000 18.26342 ? 287 GLN A CD  1 
ATOM   2313 O  OE1 . GLN A 1 287 ? 1.12909   39.26175 -23.65947 1.000 24.45674 ? 287 GLN A OE1 1 
ATOM   2314 N  NE2 . GLN A 1 287 ? 0.86353   37.53348 -22.27025 1.000 20.46436 ? 287 GLN A NE2 1 
ATOM   2315 N  N   . LYS A 1 288 ? -3.29226  40.11067 -20.37987 1.000 17.23249 ? 288 LYS A N   1 
ATOM   2316 C  CA  . LYS A 1 288 ? -4.02745  39.35646 -19.36514 1.000 15.79955 ? 288 LYS A CA  1 
ATOM   2317 C  C   . LYS A 1 288 ? -4.95876  38.33956 -20.01114 1.000 14.29781 ? 288 LYS A C   1 
ATOM   2318 O  O   . LYS A 1 288 ? -5.14495  37.23667 -19.48691 1.000 13.61955 ? 288 LYS A O   1 
ATOM   2319 C  CB  . LYS A 1 288 ? -4.84207  40.29179 -18.46345 1.000 13.96357 ? 288 LYS A CB  1 
ATOM   2320 C  CG  . LYS A 1 288 ? -4.04484  41.31895 -17.68270 1.000 20.12039 ? 288 LYS A CG  1 
ATOM   2321 C  CD  . LYS A 1 288 ? -3.18007  40.68389 -16.61386 1.000 20.86848 ? 288 LYS A CD  1 
ATOM   2322 C  CE  . LYS A 1 288 ? -4.01646  39.97698 -15.56316 1.000 21.32458 ? 288 LYS A CE  1 
ATOM   2323 N  NZ  . LYS A 1 288 ? -3.16543  39.22541 -14.58546 1.000 22.70296 ? 288 LYS A NZ  1 
ATOM   2324 N  N   . PHE A 1 289 ? -5.56192  38.69990 -21.14674 1.000 13.64223 ? 289 PHE A N   1 
ATOM   2325 C  CA  . PHE A 1 289 ? -6.48825  37.78880 -21.81128 1.000 16.84178 ? 289 PHE A CA  1 
ATOM   2326 C  C   . PHE A 1 289 ? -5.75464  36.61810 -22.43415 1.000 14.65307 ? 289 PHE A C   1 
ATOM   2327 O  O   . PHE A 1 289 ? -6.29944  35.50793 -22.49196 1.000 13.64192 ? 289 PHE A O   1 
ATOM   2328 C  CB  . PHE A 1 289 ? -7.30472  38.54305 -22.86129 1.000 12.98474 ? 289 PHE A CB  1 
ATOM   2329 C  CG  . PHE A 1 289 ? -8.16068  39.61540 -22.27154 1.000 19.11008 ? 289 PHE A CG  1 
ATOM   2330 C  CD1 . PHE A 1 289 ? -9.45070  39.33343 -21.84265 1.000 18.01288 ? 289 PHE A CD1 1 
ATOM   2331 C  CD2 . PHE A 1 289 ? -7.66050  40.89366 -22.08227 1.000 21.40872 ? 289 PHE A CD2 1 
ATOM   2332 C  CE1 . PHE A 1 289 ? -10.25028 40.32325 -21.27039 1.000 18.31737 ? 289 PHE A CE1 1 
ATOM   2333 C  CE2 . PHE A 1 289 ? -8.45489  41.88906 -21.50094 1.000 24.53627 ? 289 PHE A CE2 1 
ATOM   2334 C  CZ  . PHE A 1 289 ? -9.75272  41.59610 -21.09840 1.000 17.41660 ? 289 PHE A CZ  1 
ATOM   2335 N  N   . LEU A 1 290 ? -4.52251  36.85002 -22.89936 1.000 16.10219 ? 290 LEU A N   1 
ATOM   2336 C  CA  . LEU A 1 290 ? -3.68524  35.75764 -23.38478 1.000 15.25980 ? 290 LEU A CA  1 
ATOM   2337 C  C   . LEU A 1 290 ? -3.24408  34.86079 -22.23731 1.000 14.52942 ? 290 LEU A C   1 
ATOM   2338 O  O   . LEU A 1 290 ? -3.24411  33.63138 -22.37093 1.000 13.82027 ? 290 LEU A O   1 
ATOM   2339 C  CB  . LEU A 1 290 ? -2.46492  36.30960 -24.12811 1.000 14.32568 ? 290 LEU A CB  1 
ATOM   2340 C  CG  . LEU A 1 290 ? -2.76981  37.16928 -25.35330 1.000 18.73284 ? 290 LEU A CG  1 
ATOM   2341 C  CD1 . LEU A 1 290 ? -1.47787  37.60386 -26.03873 1.000 17.02388 ? 290 LEU A CD1 1 
ATOM   2342 C  CD2 . LEU A 1 290 ? -3.66287  36.41327 -26.32619 1.000 19.53755 ? 290 LEU A CD2 1 
ATOM   2343 N  N   . ASP A 1 291 ? -2.86186  35.45586 -21.10013 1.000 14.23699 ? 291 ASP A N   1 
ATOM   2344 C  CA  . ASP A 1 291 ? -2.52283  34.64667 -19.93292 1.000 11.18861 ? 291 ASP A CA  1 
ATOM   2345 C  C   . ASP A 1 291 ? -3.71373  33.80635 -19.48874 1.000 14.21108 ? 291 ASP A C   1 
ATOM   2346 O  O   . ASP A 1 291 ? -3.56267  32.62991 -19.13817 1.000 14.26658 ? 291 ASP A O   1 
ATOM   2347 C  CB  . ASP A 1 291 ? -2.06181  35.53271 -18.77550 1.000 16.00104 ? 291 ASP A CB  1 
ATOM   2348 C  CG  . ASP A 1 291 ? -0.83281  36.37117 -19.11140 1.000 20.19647 ? 291 ASP A CG  1 
ATOM   2349 O  OD1 . ASP A 1 291 ? -0.05924  35.99490 -20.01706 1.000 18.55399 ? 291 ASP A OD1 1 
ATOM   2350 O  OD2 . ASP A 1 291 ? -0.64393  37.41388 -18.44633 1.000 22.47418 ? 291 ASP A OD2 1 
ATOM   2351 N  N   . GLN A 1 292 ? -4.90612  34.40054 -19.47923 1.000 12.18316 ? 292 GLN A N   1 
ATOM   2352 C  CA  . GLN A 1 292 ? -6.09408  33.65660 -19.07768 1.000 12.48018 ? 292 GLN A CA  1 
ATOM   2353 C  C   . GLN A 1 292 ? -6.39626  32.52912 -20.05980 1.000 12.70820 ? 292 GLN A C   1 
ATOM   2354 O  O   . GLN A 1 292 ? -6.76122  31.42068 -19.65017 1.000 9.88710  ? 292 GLN A O   1 
ATOM   2355 C  CB  . GLN A 1 292 ? -7.27417  34.61644 -18.95954 1.000 9.96246  ? 292 GLN A CB  1 
ATOM   2356 C  CG  . GLN A 1 292 ? -8.63183  33.96509 -18.74067 1.000 10.28192 ? 292 GLN A CG  1 
ATOM   2357 C  CD  . GLN A 1 292 ? -9.72988  35.01053 -18.71882 1.000 11.86275 ? 292 GLN A CD  1 
ATOM   2358 O  OE1 . GLN A 1 292 ? -10.00010 35.66403 -19.73246 1.000 10.69675 ? 292 GLN A OE1 1 
ATOM   2359 N  NE2 . GLN A 1 292 ? -10.33952 35.20525 -17.55610 1.000 7.89941  ? 292 GLN A NE2 1 
ATOM   2360 N  N   . ALA A 1 293 ? -6.23117  32.78773 -21.36140 1.000 11.77684 ? 293 ALA A N   1 
ATOM   2361 C  CA  . ALA A 1 293 ? -6.49665  31.74809 -22.35280 1.000 13.52791 ? 293 ALA A CA  1 
ATOM   2362 C  C   . ALA A 1 293 ? -5.58863  30.53962 -22.14174 1.000 13.04007 ? 293 ALA A C   1 
ATOM   2363 O  O   . ALA A 1 293 ? -6.04774  29.39376 -22.20490 1.000 12.37503 ? 293 ALA A O   1 
ATOM   2364 C  CB  . ALA A 1 293 ? -6.32821  32.30799 -23.76606 1.000 12.89383 ? 293 ALA A CB  1 
ATOM   2365 N  N   . ALA A 1 294 ? -4.29822  30.77588 -21.87382 1.000 14.31216 ? 294 ALA A N   1 
ATOM   2366 C  CA  . ALA A 1 294 ? -3.37917  29.66583 -21.65300 1.000 13.78471 ? 294 ALA A CA  1 
ATOM   2367 C  C   . ALA A 1 294 ? -3.73813  28.90138 -20.38530 1.000 13.31965 ? 294 ALA A C   1 
ATOM   2368 O  O   . ALA A 1 294 ? -3.62823  27.67020 -20.34268 1.000 12.73422 ? 294 ALA A O   1 
ATOM   2369 C  CB  . ALA A 1 294 ? -1.93985  30.17698 -21.59333 1.000 14.72508 ? 294 ALA A CB  1 
ATOM   2370 N  N   . ARG A 1 295 ? -4.18518  29.61350 -19.34987 1.000 12.96192 ? 295 ARG A N   1 
ATOM   2371 C  CA  . ARG A 1 295 ? -4.65331  28.95358 -18.13846 1.000 13.68187 ? 295 ARG A CA  1 
ATOM   2372 C  C   . ARG A 1 295 ? -5.88695  28.09117 -18.42365 1.000 11.79606 ? 295 ARG A C   1 
ATOM   2373 O  O   . ARG A 1 295 ? -5.95535  26.92571 -18.01433 1.000 11.12524 ? 295 ARG A O   1 
ATOM   2374 C  CB  . ARG A 1 295 ? -4.93150  30.01668 -17.06923 1.000 13.00385 ? 295 ARG A CB  1 
ATOM   2375 C  CG  . ARG A 1 295 ? -5.86302  29.56856 -15.95730 1.000 15.32478 ? 295 ARG A CG  1 
ATOM   2376 C  CD  . ARG A 1 295 ? -5.21836  28.51859 -15.07378 1.000 13.67477 ? 295 ARG A CD  1 
ATOM   2377 N  NE  . ARG A 1 295 ? -5.62365  28.70723 -13.68259 1.000 15.73188 ? 295 ARG A NE  1 
ATOM   2378 C  CZ  . ARG A 1 295 ? -5.35826  27.84407 -12.70376 1.000 17.83239 ? 295 ARG A CZ  1 
ATOM   2379 N  NH1 . ARG A 1 295 ? -4.68539  26.73583 -12.96891 1.000 13.34606 ? 295 ARG A NH1 1 
ATOM   2380 N  NH2 . ARG A 1 295 ? -5.74989  28.09541 -11.45953 1.000 12.44970 ? 295 ARG A NH2 1 
ATOM   2381 N  N   . TYR A 1 296 ? -6.86397  28.64139 -19.15111 1.000 11.21144 ? 296 TYR A N   1 
ATOM   2382 C  CA  . TYR A 1 296 ? -8.05574  27.86764 -19.50815 1.000 12.61932 ? 296 TYR A CA  1 
ATOM   2383 C  C   . TYR A 1 296 ? -7.69655  26.65786 -20.36869 1.000 13.93925 ? 296 TYR A C   1 
ATOM   2384 O  O   . TYR A 1 296 ? -8.28202  25.57882 -20.21703 1.000 13.26378 ? 296 TYR A O   1 
ATOM   2385 C  CB  . TYR A 1 296 ? -9.05919  28.75760 -20.23903 1.000 10.40889 ? 296 TYR A CB  1 
ATOM   2386 C  CG  . TYR A 1 296 ? -10.16557 29.32844 -19.36562 1.000 13.25024 ? 296 TYR A CG  1 
ATOM   2387 C  CD1 . TYR A 1 296 ? -11.11715 28.49449 -18.76461 1.000 12.20468 ? 296 TYR A CD1 1 
ATOM   2388 C  CD2 . TYR A 1 296 ? -10.27935 30.70311 -19.16193 1.000 9.02378  ? 296 TYR A CD2 1 
ATOM   2389 C  CE1 . TYR A 1 296 ? -12.13949 29.01587 -17.97981 1.000 11.71476 ? 296 TYR A CE1 1 
ATOM   2390 C  CE2 . TYR A 1 296 ? -11.31002 31.23891 -18.37729 1.000 7.09138  ? 296 TYR A CE2 1 
ATOM   2391 C  CZ  . TYR A 1 296 ? -12.24314 30.38722 -17.79384 1.000 12.69287 ? 296 TYR A CZ  1 
ATOM   2392 O  OH  . TYR A 1 296 ? -13.26856 30.90082 -17.00471 1.000 8.63248  ? 296 TYR A OH  1 
ATOM   2393 N  N   . ASP A 1 297 ? -6.73204  26.82200 -21.27682 1.000 13.77784 ? 297 ASP A N   1 
ATOM   2394 C  CA  . ASP A 1 297 ? -6.27179  25.70873 -22.10487 1.000 13.76504 ? 297 ASP A CA  1 
ATOM   2395 C  C   . ASP A 1 297 ? -5.77240  24.54947 -21.24676 1.000 14.02460 ? 297 ASP A C   1 
ATOM   2396 O  O   . ASP A 1 297 ? -6.17502  23.39620 -21.44446 1.000 13.95885 ? 297 ASP A O   1 
ATOM   2397 C  CB  . ASP A 1 297 ? -5.17318  26.20267 -23.05424 1.000 15.61100 ? 297 ASP A CB  1 
ATOM   2398 C  CG  . ASP A 1 297 ? -4.57741  25.09202 -23.90723 1.000 16.37537 ? 297 ASP A CG  1 
ATOM   2399 O  OD1 . ASP A 1 297 ? -5.33141  24.29136 -24.47246 1.000 21.74859 ? 297 ASP A OD1 1 
ATOM   2400 O  OD2 . ASP A 1 297 ? -3.34008  25.01801 -24.02539 1.000 26.15901 ? 297 ASP A OD2 1 
ATOM   2401 N  N   . ARG A 1 298 ? -4.89503  24.84013 -20.27996 1.000 11.70179 ? 298 ARG A N   1 
ATOM   2402 C  CA  . ARG A 1 298 ? -4.41365  23.79712 -19.38011 1.000 15.06496 ? 298 ARG A CA  1 
ATOM   2403 C  C   . ARG A 1 298 ? -5.54813  23.24631 -18.52263 1.000 13.09595 ? 298 ARG A C   1 
ATOM   2404 O  O   . ARG A 1 298 ? -5.62790  22.03484 -18.27673 1.000 11.60603 ? 298 ARG A O   1 
ATOM   2405 C  CB  . ARG A 1 298 ? -3.29201  24.34230 -18.49308 1.000 13.36098 ? 298 ARG A CB  1 
ATOM   2406 C  CG  . ARG A 1 298 ? -2.08072  24.87656 -19.26618 1.000 16.78074 ? 298 ARG A CG  1 
ATOM   2407 C  CD  . ARG A 1 298 ? -0.91133  25.17178 -18.30686 1.000 16.29614 ? 298 ARG A CD  1 
ATOM   2408 N  NE  . ARG A 1 298 ? -1.25253  26.18582 -17.30552 1.000 18.67663 ? 298 ARG A NE  1 
ATOM   2409 C  CZ  . ARG A 1 298 ? -1.20603  27.50118 -17.51981 1.000 18.84460 ? 298 ARG A CZ  1 
ATOM   2410 N  NH1 . ARG A 1 298 ? -0.82899  27.97055 -18.70329 1.000 14.28549 ? 298 ARG A NH1 1 
ATOM   2411 N  NH2 . ARG A 1 298 ? -1.53634  28.35258 -16.54765 1.000 21.94422 ? 298 ARG A NH2 1 
ATOM   2412 N  N   . LEU A 1 299 ? -6.44667  24.12004 -18.07881 1.000 11.52086 ? 299 LEU A N   1 
ATOM   2413 C  CA  . LEU A 1 299 ? -7.47721  23.70518 -17.13419 1.000 13.96810 ? 299 LEU A CA  1 
ATOM   2414 C  C   . LEU A 1 299 ? -8.42991  22.69525 -17.76303 1.000 11.22150 ? 299 LEU A C   1 
ATOM   2415 O  O   . LEU A 1 299 ? -8.71737  21.64578 -17.17345 1.000 8.40894  ? 299 LEU A O   1 
ATOM   2416 C  CB  . LEU A 1 299 ? -8.24050  24.92998 -16.63735 1.000 10.80860 ? 299 LEU A CB  1 
ATOM   2417 C  CG  . LEU A 1 299 ? -9.20760  24.66210 -15.50194 1.000 15.76062 ? 299 LEU A CG  1 
ATOM   2418 C  CD1 . LEU A 1 299 ? -8.40840  24.34358 -14.23374 1.000 15.84140 ? 299 LEU A CD1 1 
ATOM   2419 C  CD2 . LEU A 1 299 ? -10.10787 25.88210 -15.29604 1.000 16.17260 ? 299 LEU A CD2 1 
ATOM   2420 N  N   . PHE A 1 300 ? -8.93346  22.99539 -18.96303 1.000 9.77375  ? 300 PHE A N   1 
ATOM   2421 C  CA  . PHE A 1 300 ? -9.90230  22.10083 -19.57683 1.000 8.97037  ? 300 PHE A CA  1 
ATOM   2422 C  C   . PHE A 1 300 ? -9.23222  20.85178 -20.14315 1.000 11.51818 ? 300 PHE A C   1 
ATOM   2423 O  O   . PHE A 1 300 ? -9.86804  19.79703 -20.23316 1.000 13.73201 ? 300 PHE A O   1 
ATOM   2424 C  CB  . PHE A 1 300 ? -10.71844 22.85914 -20.64035 1.000 10.35353 ? 300 PHE A CB  1 
ATOM   2425 C  CG  . PHE A 1 300 ? -11.96436 23.51774 -20.06343 1.000 12.11873 ? 300 PHE A CG  1 
ATOM   2426 C  CD1 . PHE A 1 300 ? -11.86111 24.68195 -19.30570 1.000 10.14109 ? 300 PHE A CD1 1 
ATOM   2427 C  CD2 . PHE A 1 300 ? -13.21421 22.93727 -20.21785 1.000 10.29754 ? 300 PHE A CD2 1 
ATOM   2428 C  CE1 . PHE A 1 300 ? -12.98770 25.26132 -18.71702 1.000 10.67737 ? 300 PHE A CE1 1 
ATOM   2429 C  CE2 . PHE A 1 300 ? -14.34905 23.52372 -19.64245 1.000 12.56087 ? 300 PHE A CE2 1 
ATOM   2430 C  CZ  . PHE A 1 300 ? -14.22473 24.68634 -18.88858 1.000 8.57137  ? 300 PHE A CZ  1 
ATOM   2431 N  N   . LYS A 1 301 ? -7.96029  20.94472 -20.52034 1.000 12.77400 ? 301 LYS A N   1 
ATOM   2432 C  CA  . LYS A 1 301 ? -7.20161  19.74373 -20.84508 1.000 16.06775 ? 301 LYS A CA  1 
ATOM   2433 C  C   . LYS A 1 301 ? -7.13645  18.81061 -19.64189 1.000 13.56236 ? 301 LYS A C   1 
ATOM   2434 O  O   . LYS A 1 301 ? -7.28075  17.59167 -19.78035 1.000 12.21343 ? 301 LYS A O   1 
ATOM   2435 C  CB  . LYS A 1 301 ? -5.79405  20.12829 -21.31901 1.000 16.34813 ? 301 LYS A CB  1 
ATOM   2436 C  CG  . LYS A 1 301 ? -5.25776  19.25210 -22.43322 1.000 31.64305 ? 301 LYS A CG  1 
ATOM   2437 C  CD  . LYS A 1 301 ? -4.08995  19.91778 -23.16469 1.000 34.64853 ? 301 LYS A CD  1 
ATOM   2438 C  CE  . LYS A 1 301 ? -4.44345  21.32481 -23.63518 1.000 30.17839 ? 301 LYS A CE  1 
ATOM   2439 N  NZ  . LYS A 1 301 ? -3.35525  21.97493 -24.42736 1.000 25.95882 ? 301 LYS A NZ  1 
ATOM   2440 N  N   . LEU A 1 302 ? -6.96605  19.37481 -18.44368 1.000 11.59199 ? 302 LEU A N   1 
ATOM   2441 C  CA  . LEU A 1 302 ? -6.96532  18.55864 -17.23682 1.000 12.15354 ? 302 LEU A CA  1 
ATOM   2442 C  C   . LEU A 1 302 ? -8.35895  18.01365 -16.93324 1.000 14.50475 ? 302 LEU A C   1 
ATOM   2443 O  O   . LEU A 1 302 ? -8.50238  16.85279 -16.52499 1.000 12.49800 ? 302 LEU A O   1 
ATOM   2444 C  CB  . LEU A 1 302 ? -6.42066  19.36730 -16.05607 1.000 10.05725 ? 302 LEU A CB  1 
ATOM   2445 C  CG  . LEU A 1 302 ? -6.48470  18.67475 -14.68899 1.000 14.24274 ? 302 LEU A CG  1 
ATOM   2446 C  CD1 . LEU A 1 302 ? -5.57650  17.44923 -14.65566 1.000 11.52268 ? 302 LEU A CD1 1 
ATOM   2447 C  CD2 . LEU A 1 302 ? -6.17023  19.63011 -13.51435 1.000 12.65632 ? 302 LEU A CD2 1 
ATOM   2448 N  N   . TYR A 1 303 ? -9.40281  18.81983 -17.14264 1.000 12.62940 ? 303 TYR A N   1 
ATOM   2449 C  CA  . TYR A 1 303 ? -10.75805 18.31625 -16.91408 1.000 11.32978 ? 303 TYR A CA  1 
ATOM   2450 C  C   . TYR A 1 303 ? -11.06851 17.14794 -17.84312 1.000 13.51946 ? 303 TYR A C   1 
ATOM   2451 O  O   . TYR A 1 303 ? -11.67034 16.14681 -17.42542 1.000 11.84970 ? 303 TYR A O   1 
ATOM   2452 C  CB  . TYR A 1 303 ? -11.78822 19.43343 -17.10932 1.000 9.99224  ? 303 TYR A CB  1 
ATOM   2453 C  CG  . TYR A 1 303 ? -11.79439 20.51250 -16.04245 1.000 9.69060  ? 303 TYR A CG  1 
ATOM   2454 C  CD1 . TYR A 1 303 ? -11.24369 20.28716 -14.78840 1.000 10.40048 ? 303 TYR A CD1 1 
ATOM   2455 C  CD2 . TYR A 1 303 ? -12.37396 21.75791 -16.29261 1.000 13.84035 ? 303 TYR A CD2 1 
ATOM   2456 C  CE1 . TYR A 1 303 ? -11.24802 21.27525 -13.80911 1.000 11.89865 ? 303 TYR A CE1 1 
ATOM   2457 C  CE2 . TYR A 1 303 ? -12.38690 22.75213 -15.32585 1.000 13.45517 ? 303 TYR A CE2 1 
ATOM   2458 C  CZ  . TYR A 1 303 ? -11.81901 22.50779 -14.08615 1.000 16.82601 ? 303 TYR A CZ  1 
ATOM   2459 O  OH  . TYR A 1 303 ? -11.83341 23.49044 -13.12143 1.000 13.23008 ? 303 TYR A OH  1 
ATOM   2460 N  N   . GLU A 1 304 ? -10.65574 17.24938 -19.10781 1.000 11.64864 ? 304 GLU A N   1 
ATOM   2461 C  CA  . GLU A 1 304 ? -10.87107 16.14071 -20.03344 1.000 13.68161 ? 304 GLU A CA  1 
ATOM   2462 C  C   . GLU A 1 304 ? -10.09212 14.89822 -19.60917 1.000 15.20138 ? 304 GLU A C   1 
ATOM   2463 O  O   . GLU A 1 304 ? -10.63940 13.78746 -19.61001 1.000 16.08095 ? 304 GLU A O   1 
ATOM   2464 C  CB  . GLU A 1 304 ? -10.49275 16.56958 -21.44471 1.000 14.47918 ? 304 GLU A CB  1 
ATOM   2465 C  CG  . GLU A 1 304 ? -11.55061 17.43282 -22.08304 1.000 17.17027 ? 304 GLU A CG  1 
ATOM   2466 C  CD  . GLU A 1 304 ? -11.40202 17.48714 -23.58274 1.000 19.12972 ? 304 GLU A CD  1 
ATOM   2467 O  OE1 . GLU A 1 304 ? -10.51152 18.21997 -24.05187 1.000 16.51344 ? 304 GLU A OE1 1 
ATOM   2468 O  OE2 . GLU A 1 304 ? -12.16200 16.78571 -24.27964 1.000 17.53780 ? 304 GLU A OE2 1 
ATOM   2469 N  N   . LYS A 1 305 ? -8.82042  15.06406 -19.22433 1.000 15.67094 ? 305 LYS A N   1 
ATOM   2470 C  CA  . LYS A 1 305 ? -8.06341  13.93587 -18.68316 1.000 14.30365 ? 305 LYS A CA  1 
ATOM   2471 C  C   . LYS A 1 305 ? -8.84873  13.21379 -17.59248 1.000 16.90831 ? 305 LYS A C   1 
ATOM   2472 O  O   . LYS A 1 305 ? -8.84937  11.97749 -17.52493 1.000 16.70012 ? 305 LYS A O   1 
ATOM   2473 C  CB  . LYS A 1 305 ? -6.72472  14.42027 -18.13544 1.000 13.35906 ? 305 LYS A CB  1 
ATOM   2474 C  CG  . LYS A 1 305 ? -5.80164  13.30338 -17.64911 1.000 20.36557 ? 305 LYS A CG  1 
ATOM   2475 C  CD  . LYS A 1 305 ? -4.56369  13.89867 -16.98711 1.000 21.42777 ? 305 LYS A CD  1 
ATOM   2476 C  CE  . LYS A 1 305 ? -3.51542  12.84248 -16.68192 1.000 24.76808 ? 305 LYS A CE  1 
ATOM   2477 N  NZ  . LYS A 1 305 ? -2.35995  13.46218 -15.96486 1.000 24.12101 ? 305 LYS A NZ  1 
ATOM   2478 N  N   . LEU A 1 306 ? -9.55086  13.97188 -16.74810 1.000 17.60586 ? 306 LEU A N   1 
ATOM   2479 C  CA  . LEU A 1 306 ? -10.27303 13.43231 -15.60662 1.000 13.21688 ? 306 LEU A CA  1 
ATOM   2480 C  C   . LEU A 1 306 ? -11.76484 13.30712 -15.86236 1.000 16.11901 ? 306 LEU A C   1 
ATOM   2481 O  O   . LEU A 1 306 ? -12.54632 13.30287 -14.90116 1.000 15.30782 ? 306 LEU A O   1 
ATOM   2482 C  CB  . LEU A 1 306 ? -10.03347 14.30888 -14.37685 1.000 16.47372 ? 306 LEU A CB  1 
ATOM   2483 C  CG  . LEU A 1 306 ? -8.59205  14.59856 -13.94560 1.000 18.01726 ? 306 LEU A CG  1 
ATOM   2484 C  CD1 . LEU A 1 306 ? -8.55852  15.63971 -12.82990 1.000 13.34340 ? 306 LEU A CD1 1 
ATOM   2485 C  CD2 . LEU A 1 306 ? -7.91303  13.32809 -13.48723 1.000 20.36441 ? 306 LEU A CD2 1 
ATOM   2486 N  N   . SER A 1 307 ? -12.18400 13.21187 -17.13247 1.000 14.56244 ? 307 SER A N   1 
ATOM   2487 C  CA  . SER A 1 307 ? -13.61644 13.25124 -17.42545 1.000 12.73066 ? 307 SER A CA  1 
ATOM   2488 C  C   . SER A 1 307 ? -14.36004 12.06408 -16.83905 1.000 16.82204 ? 307 SER A C   1 
ATOM   2489 O  O   . SER A 1 307 ? -15.57374 12.15535 -16.62280 1.000 14.97102 ? 307 SER A O   1 
ATOM   2490 C  CB  . SER A 1 307 ? -13.86555 13.31498 -18.92965 1.000 13.78268 ? 307 SER A CB  1 
ATOM   2491 O  OG  . SER A 1 307 ? -13.31060 12.19924 -19.59591 1.000 15.78702 ? 307 SER A OG  1 
ATOM   2492 N  N   . ASP A 1 308 ? -13.67119 10.95497 -16.56434 1.000 13.01962 ? 308 ASP A N   1 
ATOM   2493 C  CA  . ASP A 1 308 ? -14.38713 9.85348  -15.94213 1.000 20.48656 ? 308 ASP A CA  1 
ATOM   2494 C  C   . ASP A 1 308 ? -14.69109 10.14213 -14.47989 1.000 18.72340 ? 308 ASP A C   1 
ATOM   2495 O  O   . ASP A 1 308 ? -15.43376 9.38614  -13.84869 1.000 21.50628 ? 308 ASP A O   1 
ATOM   2496 C  CB  . ASP A 1 308 ? -13.60700 8.53526  -16.09711 1.000 18.97319 ? 308 ASP A CB  1 
ATOM   2497 C  CG  . ASP A 1 308 ? -12.19516 8.62217  -15.58018 1.000 25.98665 ? 308 ASP A CG  1 
ATOM   2498 O  OD1 . ASP A 1 308 ? -11.55351 9.69274  -15.70750 1.000 31.13022 ? 308 ASP A OD1 1 
ATOM   2499 O  OD2 . ASP A 1 308 ? -11.71215 7.60717  -15.04048 1.000 38.92476 ? 308 ASP A OD2 1 
ATOM   2500 N  N   . LYS A 1 309 ? -14.17807 11.24221 -13.94218 1.000 15.48281 ? 309 LYS A N   1 
ATOM   2501 C  CA  . LYS A 1 309 ? -14.41837 11.60299 -12.55698 1.000 12.50948 ? 309 LYS A CA  1 
ATOM   2502 C  C   . LYS A 1 309 ? -15.18930 12.90826 -12.40262 1.000 11.91235 ? 309 LYS A C   1 
ATOM   2503 O  O   . LYS A 1 309 ? -15.48089 13.30721 -11.26952 1.000 13.61927 ? 309 LYS A O   1 
ATOM   2504 C  CB  . LYS A 1 309 ? -13.07684 11.69427 -11.80636 1.000 18.05422 ? 309 LYS A CB  1 
ATOM   2505 C  CG  . LYS A 1 309 ? -12.33990 10.35625 -11.71468 1.000 19.17701 ? 309 LYS A CG  1 
ATOM   2506 C  CD  . LYS A 1 309 ? -10.84542 10.54812 -11.53301 1.000 24.30905 ? 309 LYS A CD  1 
ATOM   2507 C  CE  . LYS A 1 309 ? -10.09383 9.21317  -11.49915 1.000 22.75881 ? 309 LYS A CE  1 
ATOM   2508 N  NZ  . LYS A 1 309 ? -8.66101  9.42100  -11.89292 1.000 24.38182 ? 309 LYS A NZ  1 
ATOM   2509 N  N   . ILE A 1 310 ? -15.52383 13.58412 -13.49806 1.000 13.21416 ? 310 ILE A N   1 
ATOM   2510 C  CA  . ILE A 1 310 ? -16.21006 14.87097 -13.46726 1.000 12.74018 ? 310 ILE A CA  1 
ATOM   2511 C  C   . ILE A 1 310 ? -17.45734 14.76228 -14.32978 1.000 10.37520 ? 310 ILE A C   1 
ATOM   2512 O  O   . ILE A 1 310 ? -17.36527 14.44167 -15.51651 1.000 11.21675 ? 310 ILE A O   1 
ATOM   2513 C  CB  . ILE A 1 310 ? -15.30156 16.00956 -13.96154 1.000 13.61144 ? 310 ILE A CB  1 
ATOM   2514 C  CG1 . ILE A 1 310 ? -14.10153 16.17172 -13.02269 1.000 10.93366 ? 310 ILE A CG1 1 
ATOM   2515 C  CG2 . ILE A 1 310 ? -16.08977 17.31189 -14.09443 1.000 11.91640 ? 310 ILE A CG2 1 
ATOM   2516 C  CD1 . ILE A 1 310 ? -12.91678 16.92051 -13.64459 1.000 12.18264 ? 310 ILE A CD1 1 
ATOM   2517 N  N   . SER A 1 311 ? -18.62179 15.02243 -13.74054 1.000 11.44782 ? 311 SER A N   1 
ATOM   2518 C  CA  . SER A 1 311 ? -19.86753 14.97742 -14.50179 1.000 13.31743 ? 311 SER A CA  1 
ATOM   2519 C  C   . SER A 1 311 ? -20.28861 16.33324 -15.06513 1.000 11.03407 ? 311 SER A C   1 
ATOM   2520 O  O   . SER A 1 311 ? -21.06751 16.37142 -16.02458 1.000 11.34513 ? 311 SER A O   1 
ATOM   2521 C  CB  . SER A 1 311 ? -21.00166 14.43177 -13.62926 1.000 9.82312  ? 311 SER A CB  1 
ATOM   2522 O  OG  . SER A 1 311 ? -21.18027 15.26264 -12.49053 1.000 10.70040 ? 311 SER A OG  1 
ATOM   2523 N  N   . ASN A 1 312 ? -19.79005 17.43810 -14.51259 1.000 9.42215  ? 312 ASN A N   1 
ATOM   2524 C  CA  . ASN A 1 312 ? -20.28858 18.75631 -14.88493 1.000 10.32219 ? 312 ASN A CA  1 
ATOM   2525 C  C   . ASN A 1 312 ? -19.22622 19.80344 -14.59403 1.000 9.68460  ? 312 ASN A C   1 
ATOM   2526 O  O   . ASN A 1 312 ? -18.48434 19.69640 -13.60850 1.000 8.18619  ? 312 ASN A O   1 
ATOM   2527 C  CB  . ASN A 1 312 ? -21.58726 19.10031 -14.13081 1.000 10.49724 ? 312 ASN A CB  1 
ATOM   2528 C  CG  . ASN A 1 312 ? -21.91437 20.60643 -14.14946 1.000 13.09135 ? 312 ASN A CG  1 
ATOM   2529 O  OD1 . ASN A 1 312 ? -21.68843 21.31451 -13.16216 1.000 11.60802 ? 312 ASN A OD1 1 
ATOM   2530 N  ND2 . ASN A 1 312 ? -22.45789 21.09239 -15.27132 1.000 10.63084 ? 312 ASN A ND2 1 
ATOM   2531 N  N   . VAL A 1 313 ? -19.15278 20.80280 -15.46765 1.000 8.95697  ? 313 VAL A N   1 
ATOM   2532 C  CA  . VAL A 1 313 ? -18.32987 21.98971 -15.26392 1.000 9.00791  ? 313 VAL A CA  1 
ATOM   2533 C  C   . VAL A 1 313 ? -19.25652 23.17756 -15.48854 1.000 10.35175 ? 313 VAL A C   1 
ATOM   2534 O  O   . VAL A 1 313 ? -19.74543 23.38227 -16.60923 1.000 9.43175  ? 313 VAL A O   1 
ATOM   2535 C  CB  . VAL A 1 313 ? -17.11833 22.03511 -16.21458 1.000 9.82751  ? 313 VAL A CB  1 
ATOM   2536 C  CG1 . VAL A 1 313 ? -16.36429 23.35899 -16.09274 1.000 5.91527  ? 313 VAL A CG1 1 
ATOM   2537 C  CG2 . VAL A 1 313 ? -16.19148 20.85817 -15.95955 1.000 5.37604  ? 313 VAL A CG2 1 
ATOM   2538 N  N   . THR A 1 314 ? -19.53438 23.93266 -14.42598 1.000 6.96720  ? 314 THR A N   1 
ATOM   2539 C  CA  . THR A 1 314 ? -20.41150 25.09039 -14.49263 1.000 8.91828  ? 314 THR A CA  1 
ATOM   2540 C  C   . THR A 1 314 ? -19.59479 26.35818 -14.27507 1.000 10.76130 ? 314 THR A C   1 
ATOM   2541 O  O   . THR A 1 314 ? -18.82818 26.44707 -13.30794 1.000 10.61264 ? 314 THR A O   1 
ATOM   2542 C  CB  . THR A 1 314 ? -21.52448 24.99728 -13.44191 1.000 11.47372 ? 314 THR A CB  1 
ATOM   2543 O  OG1 . THR A 1 314 ? -22.34578 23.84994 -13.70550 1.000 11.38026 ? 314 THR A OG1 1 
ATOM   2544 C  CG2 . THR A 1 314 ? -22.39118 26.25988 -13.45672 1.000 7.55667  ? 314 THR A CG2 1 
ATOM   2545 N  N   . PHE A 1 315 ? -19.74633 27.31854 -15.18913 1.000 9.57592  ? 315 PHE A N   1 
ATOM   2546 C  CA  . PHE A 1 315 ? -19.21784 28.66827 -15.01483 1.000 8.65154  ? 315 PHE A CA  1 
ATOM   2547 C  C   . PHE A 1 315 ? -20.16877 29.48201 -14.14690 1.000 9.41859  ? 315 PHE A C   1 
ATOM   2548 O  O   . PHE A 1 315 ? -21.39101 29.36718 -14.27140 1.000 9.96709  ? 315 PHE A O   1 
ATOM   2549 C  CB  . PHE A 1 315 ? -19.05980 29.36357 -16.37011 1.000 9.07828  ? 315 PHE A CB  1 
ATOM   2550 C  CG  . PHE A 1 315 ? -18.00972 28.74606 -17.26905 1.000 9.73879  ? 315 PHE A CG  1 
ATOM   2551 C  CD1 . PHE A 1 315 ? -16.67384 29.08823 -17.12805 1.000 9.10870  ? 315 PHE A CD1 1 
ATOM   2552 C  CD2 . PHE A 1 315 ? -18.36444 27.83781 -18.25711 1.000 8.68752  ? 315 PHE A CD2 1 
ATOM   2553 C  CE1 . PHE A 1 315 ? -15.70643 28.53865 -17.95908 1.000 11.59110 ? 315 PHE A CE1 1 
ATOM   2554 C  CE2 . PHE A 1 315 ? -17.40114 27.28961 -19.09806 1.000 10.66075 ? 315 PHE A CE2 1 
ATOM   2555 C  CZ  . PHE A 1 315 ? -16.07210 27.63881 -18.94411 1.000 9.67854  ? 315 PHE A CZ  1 
ATOM   2556 N  N   . TRP A 1 316 ? -19.61624 30.31880 -13.26954 1.000 8.50341  ? 316 TRP A N   1 
ATOM   2557 C  CA  . TRP A 1 316 ? -20.46279 31.13664 -12.40322 1.000 8.06530  ? 316 TRP A CA  1 
ATOM   2558 C  C   . TRP A 1 316 ? -20.90316 32.40527 -13.14077 1.000 9.16300  ? 316 TRP A C   1 
ATOM   2559 O  O   . TRP A 1 316 ? -20.67145 33.53164 -12.70442 1.000 8.31496  ? 316 TRP A O   1 
ATOM   2560 C  CB  . TRP A 1 316 ? -19.75071 31.46425 -11.09382 1.000 9.93449  ? 316 TRP A CB  1 
ATOM   2561 C  CG  . TRP A 1 316 ? -20.73431 31.73158 -9.99095  1.000 14.09013 ? 316 TRP A CG  1 
ATOM   2562 C  CD1 . TRP A 1 316 ? -20.95148 32.92313 -9.33806  1.000 14.60245 ? 316 TRP A CD1 1 
ATOM   2563 C  CD2 . TRP A 1 316 ? -21.65805 30.79178 -9.42650  1.000 12.56778 ? 316 TRP A CD2 1 
ATOM   2564 N  NE1 . TRP A 1 316 ? -21.95272 32.77594 -8.40684  1.000 15.03579 ? 316 TRP A NE1 1 
ATOM   2565 C  CE2 . TRP A 1 316 ? -22.40333 31.47866 -8.43954  1.000 17.33401 ? 316 TRP A CE2 1 
ATOM   2566 C  CE3 . TRP A 1 316 ? -21.93121 29.43557 -9.66290  1.000 11.11875 ? 316 TRP A CE3 1 
ATOM   2567 C  CZ2 . TRP A 1 316 ? -23.39497 30.85076 -7.68550  1.000 18.32482 ? 316 TRP A CZ2 1 
ATOM   2568 C  CZ3 . TRP A 1 316 ? -22.92013 28.81411 -8.92462  1.000 11.68313 ? 316 TRP A CZ3 1 
ATOM   2569 C  CH2 . TRP A 1 316 ? -23.64587 29.51964 -7.94412  1.000 14.25297 ? 316 TRP A CH2 1 
ATOM   2570 N  N   . GLY A 1 317 ? -21.54952 32.19424 -14.27679 1.000 8.65014  ? 317 GLY A N   1 
ATOM   2571 C  CA  . GLY A 1 317 ? -22.05356 33.28736 -15.08508 1.000 8.22702  ? 317 GLY A CA  1 
ATOM   2572 C  C   . GLY A 1 317 ? -22.05247 32.90474 -16.55127 1.000 11.67851 ? 317 GLY A C   1 
ATOM   2573 O  O   . GLY A 1 317 ? -21.69459 31.78853 -16.93097 1.000 9.74359  ? 317 GLY A O   1 
ATOM   2574 N  N   . ILE A 1 318 ? -22.46014 33.87112 -17.37783 1.000 9.31449  ? 318 ILE A N   1 
ATOM   2575 C  CA  . ILE A 1 318 ? -22.61362 33.66813 -18.81371 1.000 6.94905  ? 318 ILE A CA  1 
ATOM   2576 C  C   . ILE A 1 318 ? -21.51304 34.38993 -19.59164 1.000 10.24484 ? 318 ILE A C   1 
ATOM   2577 O  O   . ILE A 1 318 ? -20.67695 33.74975 -20.23422 1.000 10.01339 ? 318 ILE A O   1 
ATOM   2578 C  CB  . ILE A 1 318 ? -24.01595 34.11018 -19.28597 1.000 10.32402 ? 318 ILE A CB  1 
ATOM   2579 C  CG1 . ILE A 1 318 ? -25.10193 33.39984 -18.47517 1.000 7.01198  ? 318 ILE A CG1 1 
ATOM   2580 C  CG2 . ILE A 1 318 ? -24.15195 33.90363 -20.79049 1.000 7.03737  ? 318 ILE A CG2 1 
ATOM   2581 C  CD1 . ILE A 1 318 ? -26.52816 33.81312 -18.86144 1.000 10.69370 ? 318 ILE A CD1 1 
ATOM   2582 N  N   . ALA A 1 319 ? -21.48935 35.72638 -19.53817 1.000 8.29686  ? 319 ALA A N   1 
ATOM   2583 C  CA  . ALA A 1 319 ? -20.48516 36.51289 -20.24904 1.000 9.85258  ? 319 ALA A CA  1 
ATOM   2584 C  C   . ALA A 1 319 ? -19.95010 37.60024 -19.32712 1.000 8.21832  ? 319 ALA A C   1 
ATOM   2585 O  O   . ALA A 1 319 ? -20.52153 37.88885 -18.27991 1.000 9.70179  ? 319 ALA A O   1 
ATOM   2586 C  CB  . ALA A 1 319 ? -21.04441 37.11714 -21.54630 1.000 9.40167  ? 319 ALA A CB  1 
ATOM   2587 N  N   . ASP A 1 320 ? -18.83181 38.20667 -19.72893 1.000 8.94280  ? 320 ASP A N   1 
ATOM   2588 C  CA  . ASP A 1 320 ? -18.08541 39.08102 -18.82809 1.000 12.29022 ? 320 ASP A CA  1 
ATOM   2589 C  C   . ASP A 1 320 ? -18.86482 40.32511 -18.38849 1.000 10.91548 ? 320 ASP A C   1 
ATOM   2590 O  O   . ASP A 1 320 ? -18.45056 40.98570 -17.43027 1.000 10.25381 ? 320 ASP A O   1 
ATOM   2591 C  CB  . ASP A 1 320 ? -16.75878 39.48388 -19.49254 1.000 9.34158  ? 320 ASP A CB  1 
ATOM   2592 C  CG  . ASP A 1 320 ? -15.67368 38.42235 -19.32587 1.000 9.99326  ? 320 ASP A CG  1 
ATOM   2593 O  OD1 . ASP A 1 320 ? -15.92952 37.39792 -18.64169 1.000 8.59230  ? 320 ASP A OD1 1 
ATOM   2594 O  OD2 . ASP A 1 320 ? -14.56437 38.61112 -19.88325 1.000 10.81415 ? 320 ASP A OD2 1 
ATOM   2595 N  N   . ASN A 1 321 ? -19.97769 40.66396 -19.04199 1.000 8.77506  ? 321 ASN A N   1 
ATOM   2596 C  CA  . ASN A 1 321 ? -20.74823 41.81062 -18.57034 1.000 14.76926 ? 321 ASN A CA  1 
ATOM   2597 C  C   . ASN A 1 321 ? -21.39418 41.58863 -17.20055 1.000 13.12338 ? 321 ASN A C   1 
ATOM   2598 O  O   . ASN A 1 321 ? -21.87825 42.55625 -16.61232 1.000 11.40129 ? 321 ASN A O   1 
ATOM   2599 C  CB  . ASN A 1 321 ? -21.82990 42.19171 -19.59260 1.000 10.71150 ? 321 ASN A CB  1 
ATOM   2600 C  CG  . ASN A 1 321 ? -22.77365 41.04260 -19.89710 1.000 13.44274 ? 321 ASN A CG  1 
ATOM   2601 O  OD1 . ASN A 1 321 ? -22.36122 39.88648 -19.92136 1.000 10.20126 ? 321 ASN A OD1 1 
ATOM   2602 N  ND2 . ASN A 1 321 ? -24.04947 41.35574 -20.12257 1.000 11.04034 ? 321 ASN A ND2 1 
ATOM   2603 N  N   . HIS A 1 322 ? -21.40370 40.36651 -16.66521 1.000 11.38637 ? 322 HIS A N   1 
ATOM   2604 C  CA  . HIS A 1 322 ? -22.06215 40.12730 -15.38284 1.000 11.46986 ? 322 HIS A CA  1 
ATOM   2605 C  C   . HIS A 1 322 ? -21.32716 39.02320 -14.62907 1.000 11.87229 ? 322 HIS A C   1 
ATOM   2606 O  O   . HIS A 1 322 ? -21.33835 37.85761 -15.04597 1.000 9.67027  ? 322 HIS A O   1 
ATOM   2607 C  CB  . HIS A 1 322 ? -23.53512 39.76929 -15.58653 1.000 12.40028 ? 322 HIS A CB  1 
ATOM   2608 C  CG  . HIS A 1 322 ? -24.26177 39.49183 -14.30775 1.000 18.26554 ? 322 HIS A CG  1 
ATOM   2609 N  ND1 . HIS A 1 322 ? -25.10917 40.40502 -13.71952 1.000 25.14950 ? 322 HIS A ND1 1 
ATOM   2610 C  CD2 . HIS A 1 322 ? -24.23409 38.41783 -13.48181 1.000 15.57303 ? 322 HIS A CD2 1 
ATOM   2611 C  CE1 . HIS A 1 322 ? -25.58417 39.89903 -12.59503 1.000 22.37120 ? 322 HIS A CE1 1 
ATOM   2612 N  NE2 . HIS A 1 322 ? -25.07386 38.69122 -12.43287 1.000 17.31216 ? 322 HIS A NE2 1 
ATOM   2613 N  N   . THR A 1 323 ? -20.71442 39.38188 -13.50666 1.000 9.77862  ? 323 THR A N   1 
ATOM   2614 C  CA  . THR A 1 323 ? -20.01596 38.41143 -12.67241 1.000 13.12027 ? 323 THR A CA  1 
ATOM   2615 C  C   . THR A 1 323 ? -19.97895 38.94194 -11.24885 1.000 11.81960 ? 323 THR A C   1 
ATOM   2616 O  O   . THR A 1 323 ? -19.64627 40.11281 -11.03572 1.000 11.65054 ? 323 THR A O   1 
ATOM   2617 C  CB  . THR A 1 323 ? -18.57652 38.14772 -13.15768 1.000 11.61545 ? 323 THR A CB  1 
ATOM   2618 O  OG1 . THR A 1 323 ? -17.85257 37.46649 -12.12500 1.000 9.99804  ? 323 THR A OG1 1 
ATOM   2619 C  CG2 . THR A 1 323 ? -17.85723 39.47200 -13.48038 1.000 7.77176  ? 323 THR A CG2 1 
ATOM   2620 N  N   . TRP A 1 324 ? -20.30010 38.06728 -10.28337 1.000 9.11645  ? 324 TRP A N   1 
ATOM   2621 C  CA  . TRP A 1 324 ? -20.15861 38.39940 -8.86593  1.000 11.77572 ? 324 TRP A CA  1 
ATOM   2622 C  C   . TRP A 1 324 ? -18.73103 38.80269 -8.49808  1.000 13.71913 ? 324 TRP A C   1 
ATOM   2623 O  O   . TRP A 1 324 ? -18.51669 39.40551 -7.43528  1.000 12.33828 ? 324 TRP A O   1 
ATOM   2624 C  CB  . TRP A 1 324 ? -20.59628 37.21307 -7.98578  1.000 13.36221 ? 324 TRP A CB  1 
ATOM   2625 C  CG  . TRP A 1 324 ? -19.50127 36.19593 -7.78779  1.000 16.20085 ? 324 TRP A CG  1 
ATOM   2626 C  CD1 . TRP A 1 324 ? -18.89050 35.44595 -8.76044  1.000 14.17923 ? 324 TRP A CD1 1 
ATOM   2627 C  CD2 . TRP A 1 324 ? -18.86197 35.84303 -6.55340  1.000 14.38918 ? 324 TRP A CD2 1 
ATOM   2628 N  NE1 . TRP A 1 324 ? -17.92396 34.63859 -8.20119  1.000 15.08213 ? 324 TRP A NE1 1 
ATOM   2629 C  CE2 . TRP A 1 324 ? -17.88692 34.86484 -6.85021  1.000 13.24326 ? 324 TRP A CE2 1 
ATOM   2630 C  CE3 . TRP A 1 324 ? -19.02732 36.24986 -5.22592  1.000 17.38704 ? 324 TRP A CE3 1 
ATOM   2631 C  CZ2 . TRP A 1 324 ? -17.08002 34.29411 -5.87187  1.000 15.76687 ? 324 TRP A CZ2 1 
ATOM   2632 C  CZ3 . TRP A 1 324 ? -18.22852 35.67575 -4.25178  1.000 18.18595 ? 324 TRP A CZ3 1 
ATOM   2633 C  CH2 . TRP A 1 324 ? -17.26174 34.71284 -4.58084  1.000 16.57342 ? 324 TRP A CH2 1 
ATOM   2634 N  N   . LEU A 1 325 ? -17.74877 38.47845 -9.33828  1.000 10.21466 ? 325 LEU A N   1 
ATOM   2635 C  CA  . LEU A 1 325 ? -16.37726 38.87735 -9.04701  1.000 11.88996 ? 325 LEU A CA  1 
ATOM   2636 C  C   . LEU A 1 325 ? -16.21775 40.39030 -9.01254  1.000 13.91130 ? 325 LEU A C   1 
ATOM   2637 O  O   . LEU A 1 325 ? -15.28203 40.89348 -8.37716  1.000 14.35938 ? 325 LEU A O   1 
ATOM   2638 C  CB  . LEU A 1 325 ? -15.42164 38.27612 -10.08451 1.000 8.38505  ? 325 LEU A CB  1 
ATOM   2639 C  CG  . LEU A 1 325 ? -15.22763 36.76371 -9.98963  1.000 12.29193 ? 325 LEU A CG  1 
ATOM   2640 C  CD1 . LEU A 1 325 ? -14.16893 36.30602 -11.00049 1.000 12.30913 ? 325 LEU A CD1 1 
ATOM   2641 C  CD2 . LEU A 1 325 ? -14.83485 36.39268 -8.55877  1.000 9.36800  ? 325 LEU A CD2 1 
ATOM   2642 N  N   . ASP A 1 326 ? -17.08813 41.12980 -9.70263  1.000 10.12947 ? 326 ASP A N   1 
ATOM   2643 C  CA  . ASP A 1 326 ? -16.97728 42.58201 -9.66211  1.000 12.15549 ? 326 ASP A CA  1 
ATOM   2644 C  C   . ASP A 1 326 ? -17.16423 43.11755 -8.24639  1.000 15.44515 ? 326 ASP A C   1 
ATOM   2645 O  O   . ASP A 1 326 ? -16.57137 44.14120 -7.88675  1.000 17.09949 ? 326 ASP A O   1 
ATOM   2646 C  CB  . ASP A 1 326 ? -17.98565 43.19647 -10.62557 1.000 12.28923 ? 326 ASP A CB  1 
ATOM   2647 C  CG  . ASP A 1 326 ? -17.59068 42.98001 -12.08243 1.000 14.02149 ? 326 ASP A CG  1 
ATOM   2648 O  OD1 . ASP A 1 326 ? -16.39236 42.72246 -12.32098 1.000 14.16634 ? 326 ASP A OD1 1 
ATOM   2649 O  OD2 . ASP A 1 326 ? -18.45626 43.06885 -12.98638 1.000 12.50118 ? 326 ASP A OD2 1 
ATOM   2650 N  N   . SER A 1 327 ? -17.95962 42.42816 -7.42236  1.000 11.91338 ? 327 SER A N   1 
ATOM   2651 C  CA  . SER A 1 327 ? -18.11522 42.81323 -6.02453  1.000 17.06745 ? 327 SER A CA  1 
ATOM   2652 C  C   . SER A 1 327 ? -16.80575 42.71900 -5.24433  1.000 17.33418 ? 327 SER A C   1 
ATOM   2653 O  O   . SER A 1 327 ? -16.67604 43.35844 -4.19431  1.000 17.16263 ? 327 SER A O   1 
ATOM   2654 C  CB  . SER A 1 327 ? -19.20468 41.95159 -5.37412  1.000 16.16996 ? 327 SER A CB  1 
ATOM   2655 O  OG  . SER A 1 327 ? -18.66661 40.71937 -4.89817  1.000 19.82060 ? 327 SER A OG  1 
ATOM   2656 N  N   . ARG A 1 328 ? -15.82875 41.96483 -5.74196  1.000 14.23674 ? 328 ARG A N   1 
ATOM   2657 C  CA  . ARG A 1 328 ? -14.51140 41.86350 -5.11913  1.000 17.33543 ? 328 ARG A CA  1 
ATOM   2658 C  C   . ARG A 1 328 ? -13.46097 42.71197 -5.82856  1.000 19.74942 ? 328 ARG A C   1 
ATOM   2659 O  O   . ARG A 1 328 ? -12.30074 42.74230 -5.39118  1.000 15.28288 ? 328 ARG A O   1 
ATOM   2660 C  CB  . ARG A 1 328 ? -14.04962 40.39580 -5.08373  1.000 14.08692 ? 328 ARG A CB  1 
ATOM   2661 C  CG  . ARG A 1 328 ? -14.93570 39.48837 -4.22847  1.000 14.66383 ? 328 ARG A CG  1 
ATOM   2662 C  CD  . ARG A 1 328 ? -15.34930 38.19802 -4.94624  1.000 18.80635 ? 328 ARG A CD  1 
ATOM   2663 N  NE  . ARG A 1 328 ? -14.26445 37.21980 -5.14482  1.000 17.88607 ? 328 ARG A NE  1 
ATOM   2664 C  CZ  . ARG A 1 328 ? -13.91970 36.26090 -4.27757  1.000 21.50889 ? 328 ARG A CZ  1 
ATOM   2665 N  NH1 . ARG A 1 328 ? -14.54892 36.12948 -3.11010  1.000 22.46334 ? 328 ARG A NH1 1 
ATOM   2666 N  NH2 . ARG A 1 328 ? -12.93709 35.42424 -4.57814  1.000 18.05173 ? 328 ARG A NH2 1 
ATOM   2667 N  N   . ALA A 1 329 ? -13.83912 43.40842 -6.90450  1.000 14.91392 ? 329 ALA A N   1 
ATOM   2668 C  CA  . ALA A 1 329 ? -12.87689 44.09451 -7.77021  1.000 14.56536 ? 329 ALA A CA  1 
ATOM   2669 C  C   . ALA A 1 329 ? -12.55856 45.47915 -7.19588  1.000 14.02901 ? 329 ALA A C   1 
ATOM   2670 O  O   . ALA A 1 329 ? -13.00585 46.51973 -7.68545  1.000 13.65632 ? 329 ALA A O   1 
ATOM   2671 C  CB  . ALA A 1 329 ? -13.42103 44.17473 -9.19548  1.000 11.97252 ? 329 ALA A CB  1 
ATOM   2672 N  N   . ASP A 1 330 ? -11.77935 45.47150 -6.11471  1.000 13.62576 ? 330 ASP A N   1 
ATOM   2673 C  CA  . ASP A 1 330 ? -11.39172 46.71343 -5.45888  1.000 16.13265 ? 330 ASP A CA  1 
ATOM   2674 C  C   . ASP A 1 330 ? -10.35214 47.44893 -6.29495  1.000 13.99209 ? 330 ASP A C   1 
ATOM   2675 O  O   . ASP A 1 330 ? -9.40371  46.84444 -6.79952  1.000 13.88660 ? 330 ASP A O   1 
ATOM   2676 C  CB  . ASP A 1 330 ? -10.81582 46.43993 -4.07324  1.000 16.74604 ? 330 ASP A CB  1 
ATOM   2677 C  CG  . ASP A 1 330 ? -11.71379 45.57418 -3.20936  1.000 15.64647 ? 330 ASP A CG  1 
ATOM   2678 O  OD1 . ASP A 1 330 ? -12.94384 45.56363 -3.41281  1.000 16.39792 ? 330 ASP A OD1 1 
ATOM   2679 O  OD2 . ASP A 1 330 ? -11.16969 44.90330 -2.30551  1.000 18.42855 ? 330 ASP A OD2 1 
ATOM   2680 N  N   . VAL A 1 331 ? -10.52907 48.75832 -6.45081  1.000 12.39322 ? 331 VAL A N   1 
ATOM   2681 C  CA  . VAL A 1 331 ? -9.59250  49.57529 -7.21580  1.000 13.17607 ? 331 VAL A CA  1 
ATOM   2682 C  C   . VAL A 1 331 ? -8.77923  50.40488 -6.23757  1.000 14.08484 ? 331 VAL A C   1 
ATOM   2683 O  O   . VAL A 1 331 ? -9.34001  51.14152 -5.41373  1.000 17.34767 ? 331 VAL A O   1 
ATOM   2684 C  CB  . VAL A 1 331 ? -10.30196 50.47492 -8.23979  1.000 16.47428 ? 331 VAL A CB  1 
ATOM   2685 C  CG1 . VAL A 1 331 ? -9.27925  51.14057 -9.13731  1.000 14.91974 ? 331 VAL A CG1 1 
ATOM   2686 C  CG2 . VAL A 1 331 ? -11.28799 49.66454 -9.07050  1.000 15.08941 ? 331 VAL A CG2 1 
ATOM   2687 N  N   . TYR A 1 332 ? -7.46361  50.28073 -6.33834  1.000 14.29067 ? 332 TYR A N   1 
ATOM   2688 C  CA  . TYR A 1 332 ? -6.50421  50.99162 -5.50752  1.000 15.46560 ? 332 TYR A CA  1 
ATOM   2689 C  C   . TYR A 1 332 ? -5.95440  52.18826 -6.27181  1.000 17.47024 ? 332 TYR A C   1 
ATOM   2690 O  O   . TYR A 1 332 ? -5.61540  52.07753 -7.45818  1.000 16.36965 ? 332 TYR A O   1 
ATOM   2691 C  CB  . TYR A 1 332 ? -5.35015  50.06678 -5.10276  1.000 14.92439 ? 332 TYR A CB  1 
ATOM   2692 C  CG  . TYR A 1 332 ? -5.74080  48.92290 -4.18373  1.000 18.67788 ? 332 TYR A CG  1 
ATOM   2693 C  CD1 . TYR A 1 332 ? -6.65095  47.95018 -4.59092  1.000 15.59820 ? 332 TYR A CD1 1 
ATOM   2694 C  CD2 . TYR A 1 332 ? -5.19401  48.81648 -2.90674  1.000 22.07961 ? 332 TYR A CD2 1 
ATOM   2695 C  CE1 . TYR A 1 332 ? -7.01261  46.91035 -3.75760  1.000 14.38322 ? 332 TYR A CE1 1 
ATOM   2696 C  CE2 . TYR A 1 332 ? -5.54896  47.76705 -2.05603  1.000 22.17483 ? 332 TYR A CE2 1 
ATOM   2697 C  CZ  . TYR A 1 332 ? -6.45912  46.81822 -2.49506  1.000 20.70895 ? 332 TYR A CZ  1 
ATOM   2698 O  OH  . TYR A 1 332 ? -6.81318  45.77138 -1.67583  1.000 15.48227 ? 332 TYR A OH  1 
ATOM   2699 N  N   . TYR A 1 333 ? -5.84995  53.32501 -5.58115  1.000 16.94490 ? 333 TYR A N   1 
ATOM   2700 C  CA  . TYR A 1 333 ? -5.39639  54.58070 -6.17441  1.000 19.03226 ? 333 TYR A CA  1 
ATOM   2701 C  C   . TYR A 1 333 ? -4.23062  55.15288 -5.38164  1.000 18.99110 ? 333 TYR A C   1 
ATOM   2702 O  O   . TYR A 1 333 ? -4.29610  55.22878 -4.14836  1.000 19.08381 ? 333 TYR A O   1 
ATOM   2703 C  CB  . TYR A 1 333 ? -6.52838  55.60616 -6.20012  1.000 20.37969 ? 333 TYR A CB  1 
ATOM   2704 C  CG  . TYR A 1 333 ? -7.64531  55.27021 -7.15134  1.000 17.79498 ? 333 TYR A CG  1 
ATOM   2705 C  CD1 . TYR A 1 333 ? -7.57917  55.65115 -8.48081  1.000 18.80753 ? 333 TYR A CD1 1 
ATOM   2706 C  CD2 . TYR A 1 333 ? -8.77003  54.58925 -6.71496  1.000 20.62024 ? 333 TYR A CD2 1 
ATOM   2707 C  CE1 . TYR A 1 333 ? -8.60328  55.36029 -9.36126  1.000 22.87300 ? 333 TYR A CE1 1 
ATOM   2708 C  CE2 . TYR A 1 333 ? -9.79945  54.29407 -7.57894  1.000 22.25027 ? 333 TYR A CE2 1 
ATOM   2709 C  CZ  . TYR A 1 333 ? -9.71287  54.68183 -8.90194  1.000 24.11380 ? 333 TYR A CZ  1 
ATOM   2710 O  OH  . TYR A 1 333 ? -10.73155 54.37489 -9.77308  1.000 23.16024 ? 333 TYR A OH  1 
ATOM   2711 N  N   . ASP A 1 334 ? -3.18282  55.58212 -6.08668  1.000 20.18307 ? 334 ASP A N   1 
ATOM   2712 C  CA  . ASP A 1 334 ? -2.05599  56.22727 -5.42961  1.000 19.55101 ? 334 ASP A CA  1 
ATOM   2713 C  C   . ASP A 1 334 ? -2.40599  57.67553 -5.07998  1.000 23.37798 ? 334 ASP A C   1 
ATOM   2714 O  O   . ASP A 1 334 ? -3.53975  58.13942 -5.26033  1.000 26.69554 ? 334 ASP A O   1 
ATOM   2715 C  CB  . ASP A 1 334 ? -0.79401  56.12270 -6.29200  1.000 18.20029 ? 334 ASP A CB  1 
ATOM   2716 C  CG  . ASP A 1 334 ? -0.87201  56.92784 -7.58298  1.000 19.29762 ? 334 ASP A CG  1 
ATOM   2717 O  OD1 . ASP A 1 334 ? -1.65528  57.89051 -7.68220  1.000 25.05111 ? 334 ASP A OD1 1 
ATOM   2718 O  OD2 . ASP A 1 334 ? -0.13090  56.58704 -8.52381  1.000 31.19527 ? 334 ASP A OD2 1 
ATOM   2719 N  N   . ALA A 1 335 ? -1.41544  58.40452 -4.56464  1.000 25.73877 ? 335 ALA A N   1 
ATOM   2720 C  CA  . ALA A 1 335 ? -1.67642  59.75999 -4.08178  1.000 29.52613 ? 335 ALA A CA  1 
ATOM   2721 C  C   . ALA A 1 335 ? -2.00171  60.72186 -5.22288  1.000 28.08542 ? 335 ALA A C   1 
ATOM   2722 O  O   . ALA A 1 335 ? -2.69613  61.71705 -5.00853  1.000 32.28829 ? 335 ALA A O   1 
ATOM   2723 C  CB  . ALA A 1 335 ? -0.47808  60.26811 -3.27607  1.000 27.03315 ? 335 ALA A CB  1 
ATOM   2724 N  N   . ASN A 1 336 ? -1.51688  60.44862 -6.43177  1.000 26.77777 ? 336 ASN A N   1 
ATOM   2725 C  CA  . ASN A 1 336 ? -1.84329  61.25252 -7.60182  1.000 28.84540 ? 336 ASN A CA  1 
ATOM   2726 C  C   . ASN A 1 336 ? -3.11624  60.80293 -8.30645  1.000 33.57157 ? 336 ASN A C   1 
ATOM   2727 O  O   . ASN A 1 336 ? -3.43913  61.35182 -9.36479  1.000 36.63425 ? 336 ASN A O   1 
ATOM   2728 C  CB  . ASN A 1 336 ? -0.68988  61.22802 -8.60571  1.000 27.60529 ? 336 ASN A CB  1 
ATOM   2729 C  CG  . ASN A 1 336 ? 0.58920   61.75664 -8.01820  1.000 34.72443 ? 336 ASN A CG  1 
ATOM   2730 O  OD1 . ASN A 1 336 ? 0.56428   62.61496 -7.13678  1.000 40.05683 ? 336 ASN A OD1 1 
ATOM   2731 N  ND2 . ASN A 1 336 ? 1.71780   61.24986 -8.49677  1.000 36.12637 ? 336 ASN A ND2 1 
ATOM   2732 N  N   . GLY A 1 337 ? -3.83010  59.81367 -7.76886  1.000 27.26733 ? 337 GLY A N   1 
ATOM   2733 C  CA  . GLY A 1 337 ? -5.06296  59.35962 -8.37539  1.000 25.44708 ? 337 GLY A CA  1 
ATOM   2734 C  C   . GLY A 1 337 ? -4.91130  58.37987 -9.51871  1.000 23.61914 ? 337 GLY A C   1 
ATOM   2735 O  O   . GLY A 1 337 ? -5.88359  58.14258 -10.23745 1.000 29.45287 ? 337 GLY A O   1 
ATOM   2736 N  N   . ASN A 1 338 ? -3.73048  57.81508 -9.73117  1.000 25.95802 ? 338 ASN A N   1 
ATOM   2737 C  CA  . ASN A 1 338 ? -3.57409  56.77071 -10.73084 1.000 25.67894 ? 338 ASN A CA  1 
ATOM   2738 C  C   . ASN A 1 338 ? -3.85008  55.40085 -10.11774 1.000 26.97660 ? 338 ASN A C   1 
ATOM   2739 O  O   . ASN A 1 338 ? -3.67367  55.18239 -8.91220  1.000 21.78790 ? 338 ASN A O   1 
ATOM   2740 C  CB  . ASN A 1 338 ? -2.17579  56.80291 -11.34651 1.000 24.26345 ? 338 ASN A CB  1 
ATOM   2741 C  CG  . ASN A 1 338 ? -1.77750  58.19666 -11.81588 1.000 37.70321 ? 338 ASN A CG  1 
ATOM   2742 O  OD1 . ASN A 1 338 ? -0.71231  58.70404 -11.46403 1.000 36.50503 ? 338 ASN A OD1 1 
ATOM   2743 N  ND2 . ASN A 1 338 ? -2.64645  58.82790 -12.59856 1.000 37.14997 ? 338 ASN A ND2 1 
ATOM   2744 N  N   . VAL A 1 339 ? -4.29879  54.47933 -10.97144 1.000 21.40839 ? 339 VAL A N   1 
ATOM   2745 C  CA  . VAL A 1 339 ? -4.69112  53.14347 -10.53488 1.000 20.15341 ? 339 VAL A CA  1 
ATOM   2746 C  C   . VAL A 1 339 ? -3.45486  52.32792 -10.18413 1.000 19.51710 ? 339 VAL A C   1 
ATOM   2747 O  O   . VAL A 1 339 ? -2.45330  52.34909 -10.91096 1.000 20.71475 ? 339 VAL A O   1 
ATOM   2748 C  CB  . VAL A 1 339 ? -5.50749  52.45278 -11.64000 1.000 17.12092 ? 339 VAL A CB  1 
ATOM   2749 C  CG1 . VAL A 1 339 ? -5.62422  50.96007 -11.36439 1.000 15.68686 ? 339 VAL A CG1 1 
ATOM   2750 C  CG2 . VAL A 1 339 ? -6.87552  53.09663 -11.76461 1.000 17.06043 ? 339 VAL A CG2 1 
ATOM   2751 N  N   . VAL A 1 340 ? -3.52220  51.59478 -9.07034  1.000 19.25147 ? 340 VAL A N   1 
ATOM   2752 C  CA  . VAL A 1 340 ? -2.44457  50.70771 -8.62864  1.000 20.24932 ? 340 VAL A CA  1 
ATOM   2753 C  C   . VAL A 1 340 ? -2.93423  49.26760 -8.72625  1.000 17.34399 ? 340 VAL A C   1 
ATOM   2754 O  O   . VAL A 1 340 ? -3.89336  48.88573 -8.04238  1.000 16.42786 ? 340 VAL A O   1 
ATOM   2755 C  CB  . VAL A 1 340 ? -1.99475  51.02271 -7.19138  1.000 19.53214 ? 340 VAL A CB  1 
ATOM   2756 C  CG1 . VAL A 1 340 ? -0.84582  50.08911 -6.77070  1.000 14.78430 ? 340 VAL A CG1 1 
ATOM   2757 C  CG2 . VAL A 1 340 ? -1.60992  52.48899 -7.04839  1.000 19.26545 ? 340 VAL A CG2 1 
ATOM   2758 N  N   . VAL A 1 341 ? -2.27725  48.46609 -9.56612  1.000 14.78480 ? 341 VAL A N   1 
ATOM   2759 C  CA  . VAL A 1 341 ? -2.60344  47.04855 -9.69283  1.000 16.93180 ? 341 VAL A CA  1 
ATOM   2760 C  C   . VAL A 1 341 ? -1.47184  46.14212 -9.22672  1.000 20.25314 ? 341 VAL A C   1 
ATOM   2761 O  O   . VAL A 1 341 ? -1.70384  44.93469 -9.04478  1.000 21.73493 ? 341 VAL A O   1 
ATOM   2762 C  CB  . VAL A 1 341 ? -3.01311  46.68707 -11.13735 1.000 18.50357 ? 341 VAL A CB  1 
ATOM   2763 C  CG1 . VAL A 1 341 ? -4.22678  47.51019 -11.57280 1.000 15.66400 ? 341 VAL A CG1 1 
ATOM   2764 C  CG2 . VAL A 1 341 ? -1.84409  46.88324 -12.10506 1.000 19.45600 ? 341 VAL A CG2 1 
ATOM   2765 N  N   . ASP A 1 342 ? -0.26793  46.67213 -9.03461  1.000 20.78189 ? 342 ASP A N   1 
ATOM   2766 C  CA  . ASP A 1 342 ? 0.84173   45.90573 -8.45598  1.000 22.83933 ? 342 ASP A CA  1 
ATOM   2767 C  C   . ASP A 1 342 ? 0.50463   45.56056 -7.00764  1.000 21.99070 ? 342 ASP A C   1 
ATOM   2768 O  O   . ASP A 1 342 ? 0.23624   46.46538 -6.20885  1.000 21.55114 ? 342 ASP A O   1 
ATOM   2769 C  CB  . ASP A 1 342 ? 2.12663   46.73022 -8.57488  1.000 27.91405 ? 342 ASP A CB  1 
ATOM   2770 C  CG  . ASP A 1 342 ? 3.34465   46.09847 -7.87435  1.000 35.25283 ? 342 ASP A CG  1 
ATOM   2771 O  OD1 . ASP A 1 342 ? 3.21072   45.12134 -7.10009  1.000 39.07334 ? 342 ASP A OD1 1 
ATOM   2772 O  OD2 . ASP A 1 342 ? 4.46762   46.62366 -8.08848  1.000 34.43906 ? 342 ASP A OD2 1 
ATOM   2773 N  N   . PRO A 1 343 ? 0.50016   44.28029 -6.62764  1.000 23.82106 ? 343 PRO A N   1 
ATOM   2774 C  CA  . PRO A 1 343 ? -0.00790  43.90515 -5.29507  1.000 26.57090 ? 343 PRO A CA  1 
ATOM   2775 C  C   . PRO A 1 343 ? 0.82212   44.42189 -4.12083  1.000 29.44207 ? 343 PRO A C   1 
ATOM   2776 O  O   . PRO A 1 343 ? 0.33238   44.39459 -2.98217  1.000 29.14171 ? 343 PRO A O   1 
ATOM   2777 C  CB  . PRO A 1 343 ? -0.01844  42.36836 -5.34286  1.000 24.55608 ? 343 PRO A CB  1 
ATOM   2778 C  CG  . PRO A 1 343 ? 0.87221   42.00129 -6.48983  1.000 30.29891 ? 343 PRO A CG  1 
ATOM   2779 C  CD  . PRO A 1 343 ? 0.74375   43.11044 -7.48543  1.000 26.84581 ? 343 PRO A CD  1 
ATOM   2780 N  N   . ASN A 1 344 ? 2.03632   44.91575 -4.34312  1.000 25.86455 ? 344 ASN A N   1 
ATOM   2781 C  CA  . ASN A 1 344 ? 2.84879   45.39441 -3.23480  1.000 37.05814 ? 344 ASN A CA  1 
ATOM   2782 C  C   . ASN A 1 344 ? 3.10044   46.89813 -3.25670  1.000 36.33120 ? 344 ASN A C   1 
ATOM   2783 O  O   . ASN A 1 344 ? 3.68688   47.42284 -2.29572  1.000 33.74360 ? 344 ASN A O   1 
ATOM   2784 C  CB  . ASN A 1 344 ? 4.18793   44.63545 -3.19517  1.000 39.94238 ? 344 ASN A CB  1 
ATOM   2785 C  CG  . ASN A 1 344 ? 3.99256   43.14264 -2.93980  1.000 42.30967 ? 344 ASN A CG  1 
ATOM   2786 O  OD1 . ASN A 1 344 ? 3.36502   42.76790 -1.93414  1.000 45.76638 ? 344 ASN A OD1 1 
ATOM   2787 N  ND2 . ASN A 1 344 ? 4.55619   42.29653 -3.79155  1.000 35.52026 ? 344 ASN A ND2 1 
ATOM   2788 N  N   . ALA A 1 345 ? 2.64501   47.60363 -4.29793  1.000 24.86005 ? 345 ALA A N   1 
ATOM   2789 C  CA  . ALA A 1 345 ? 2.99993   48.99704 -4.50286  1.000 24.90091 ? 345 ALA A CA  1 
ATOM   2790 C  C   . ALA A 1 345 ? 2.28596   49.92076 -3.52143  1.000 20.52533 ? 345 ALA A C   1 
ATOM   2791 O  O   . ALA A 1 345 ? 1.22803   49.58579 -2.97992  1.000 18.45652 ? 345 ALA A O   1 
ATOM   2792 C  CB  . ALA A 1 345 ? 2.66220   49.40799 -5.92946  1.000 22.71750 ? 345 ALA A CB  1 
ATOM   2793 N  N   . PRO A 1 346 ? 2.84280   51.10938 -3.30125  1.000 21.63656 ? 346 PRO A N   1 
ATOM   2794 C  CA  . PRO A 1 346 ? 2.14993   52.11039 -2.48805  1.000 21.67804 ? 346 PRO A CA  1 
ATOM   2795 C  C   . PRO A 1 346 ? 0.79387   52.49042 -3.06205  1.000 21.86938 ? 346 PRO A C   1 
ATOM   2796 O  O   . PRO A 1 346 ? 0.55327   52.43641 -4.27127  1.000 17.12347 ? 346 PRO A O   1 
ATOM   2797 C  CB  . PRO A 1 346 ? 3.09950   53.31577 -2.51225  1.000 19.33897 ? 346 PRO A CB  1 
ATOM   2798 C  CG  . PRO A 1 346 ? 4.39466   52.79114 -2.94568  1.000 21.44555 ? 346 PRO A CG  1 
ATOM   2799 C  CD  . PRO A 1 346 ? 4.14424   51.59260 -3.79394  1.000 20.76286 ? 346 PRO A CD  1 
ATOM   2800 N  N   . TYR A 1 347 ? -0.08451  52.92221 -2.16798  1.000 15.83929 ? 347 TYR A N   1 
ATOM   2801 C  CA  . TYR A 1 347 ? -1.38485  53.41625 -2.56656  1.000 18.02054 ? 347 TYR A CA  1 
ATOM   2802 C  C   . TYR A 1 347 ? -1.94620  54.19638 -1.39067  1.000 22.81696 ? 347 TYR A C   1 
ATOM   2803 O  O   . TYR A 1 347 ? -1.49797  54.04013 -0.24751  1.000 18.91696 ? 347 TYR A O   1 
ATOM   2804 C  CB  . TYR A 1 347 ? -2.30765  52.27152 -3.00035  1.000 17.44250 ? 347 TYR A CB  1 
ATOM   2805 C  CG  . TYR A 1 347 ? -2.98620  51.53705 -1.86788  1.000 19.75225 ? 347 TYR A CG  1 
ATOM   2806 C  CD1 . TYR A 1 347 ? -2.38585  50.43450 -1.26297  1.000 18.47575 ? 347 TYR A CD1 1 
ATOM   2807 C  CD2 . TYR A 1 347 ? -4.23630  51.93560 -1.41014  1.000 18.31994 ? 347 TYR A CD2 1 
ATOM   2808 C  CE1 . TYR A 1 347 ? -3.02197  49.75087 -0.22428  1.000 17.43077 ? 347 TYR A CE1 1 
ATOM   2809 C  CE2 . TYR A 1 347 ? -4.87751  51.26070 -0.37222  1.000 20.46679 ? 347 TYR A CE2 1 
ATOM   2810 C  CZ  . TYR A 1 347 ? -4.26783  50.17351 0.21122   1.000 20.06420 ? 347 TYR A CZ  1 
ATOM   2811 O  OH  . TYR A 1 347 ? -4.91072  49.51672 1.23185   1.000 26.35301 ? 347 TYR A OH  1 
ATOM   2812 N  N   . ALA A 1 348 ? -2.92025  55.05155 -1.69006  1.000 18.03069 ? 348 ALA A N   1 
ATOM   2813 C  CA  . ALA A 1 348 ? -3.51204  55.93579 -0.69904  1.000 19.08738 ? 348 ALA A CA  1 
ATOM   2814 C  C   . ALA A 1 348 ? -4.92643  55.55085 -0.30955  1.000 25.86550 ? 348 ALA A C   1 
ATOM   2815 O  O   . ALA A 1 348 ? -5.28603  55.65781 0.86457   1.000 26.19632 ? 348 ALA A O   1 
ATOM   2816 C  CB  . ALA A 1 348 ? -3.52367  57.37858 -1.21695  1.000 22.25553 ? 348 ALA A CB  1 
ATOM   2817 N  N   . LYS A 1 349 ? -5.75509  55.13059 -1.26174  1.000 23.19217 ? 349 LYS A N   1 
ATOM   2818 C  CA  . LYS A 1 349 ? -7.12598  54.77601 -0.93940  1.000 21.47104 ? 349 LYS A CA  1 
ATOM   2819 C  C   . LYS A 1 349 ? -7.57665  53.64131 -1.84519  1.000 19.05318 ? 349 LYS A C   1 
ATOM   2820 O  O   . LYS A 1 349 ? -6.94490  53.33093 -2.85834  1.000 20.27325 ? 349 LYS A O   1 
ATOM   2821 C  CB  . LYS A 1 349 ? -8.05702  55.98633 -1.06242  1.000 24.05876 ? 349 LYS A CB  1 
ATOM   2822 C  CG  . LYS A 1 349 ? -8.25081  56.49025 -2.48876  1.000 27.89364 ? 349 LYS A CG  1 
ATOM   2823 C  CD  . LYS A 1 349 ? -9.50443  57.37060 -2.57645  1.000 40.40000 ? 349 LYS A CD  1 
ATOM   2824 C  CE  . LYS A 1 349 ? -9.87256  57.74862 -4.01785  1.000 41.12500 ? 349 LYS A CE  1 
ATOM   2825 N  NZ  . LYS A 1 349 ? -9.11418  58.92453 -4.55259  1.000 32.15228 ? 349 LYS A NZ  1 
ATOM   2826 N  N   . VAL A 1 350 ? -8.68768  53.02247 -1.46548  1.000 19.90576 ? 350 VAL A N   1 
ATOM   2827 C  CA  . VAL A 1 350 ? -9.27885  51.93150 -2.22643  1.000 21.00954 ? 350 VAL A CA  1 
ATOM   2828 C  C   . VAL A 1 350 ? -10.77115 52.20026 -2.40001  1.000 21.72157 ? 350 VAL A C   1 
ATOM   2829 O  O   . VAL A 1 350 ? -11.43572 52.69111 -1.48295  1.000 18.92673 ? 350 VAL A O   1 
ATOM   2830 C  CB  . VAL A 1 350 ? -9.03213  50.56806 -1.53875  1.000 21.05025 ? 350 VAL A CB  1 
ATOM   2831 C  CG1 . VAL A 1 350 ? -9.65401  50.54555 -0.14535  1.000 23.92590 ? 350 VAL A CG1 1 
ATOM   2832 C  CG2 . VAL A 1 350 ? -9.58238  49.43570 -2.38662  1.000 19.06319 ? 350 VAL A CG2 1 
ATOM   2833 N  N   . GLU A 1 351 ? -11.29884 51.87970 -3.58214  1.000 19.47450 ? 351 GLU A N   1 
ATOM   2834 C  CA  . GLU A 1 351 ? -12.73390 51.93861 -3.85348  1.000 21.89282 ? 351 GLU A CA  1 
ATOM   2835 C  C   . GLU A 1 351 ? -13.24355 50.50388 -3.97388  1.000 19.00351 ? 351 GLU A C   1 
ATOM   2836 O  O   . GLU A 1 351 ? -13.07086 49.85360 -5.01143  1.000 16.56491 ? 351 GLU A O   1 
ATOM   2837 C  CB  . GLU A 1 351 ? -13.00214 52.76111 -5.10657  1.000 18.35910 ? 351 GLU A CB  1 
ATOM   2838 C  CG  . GLU A 1 351 ? -12.75144 54.25265 -4.88377  1.000 26.42970 ? 351 GLU A CG  1 
ATOM   2839 C  CD  . GLU A 1 351 ? -12.96191 55.08305 -6.13948  1.000 33.15329 ? 351 GLU A CD  1 
ATOM   2840 O  OE1 . GLU A 1 351 ? -13.37032 54.51085 -7.17953  1.000 33.68600 ? 351 GLU A OE1 1 
ATOM   2841 O  OE2 . GLU A 1 351 ? -12.70265 56.30724 -6.09344  1.000 40.42146 ? 351 GLU A OE2 1 
ATOM   2842 N  N   . LYS A 1 352 ? -13.87216 50.00749 -2.91414  1.000 15.48885 ? 352 LYS A N   1 
ATOM   2843 C  CA  . LYS A 1 352 ? -14.13496 48.57784 -2.84623  1.000 17.95729 ? 352 LYS A CA  1 
ATOM   2844 C  C   . LYS A 1 352 ? -15.24550 48.17980 -3.81129  1.000 18.10056 ? 352 LYS A C   1 
ATOM   2845 O  O   . LYS A 1 352 ? -16.28869 48.83459 -3.89078  1.000 19.38258 ? 352 LYS A O   1 
ATOM   2846 C  CB  . LYS A 1 352 ? -14.46646 48.16171 -1.41495  1.000 22.59345 ? 352 LYS A CB  1 
ATOM   2847 C  CG  . LYS A 1 352 ? -13.20799 47.66233 -0.67492  1.000 29.67818 ? 352 LYS A CG  1 
ATOM   2848 C  CD  . LYS A 1 352 ? -13.43319 47.32350 0.79609   1.000 38.39586 ? 352 LYS A CD  1 
ATOM   2849 C  CE  . LYS A 1 352 ? -12.09905 47.06681 1.50292   1.000 46.38453 ? 352 LYS A CE  1 
ATOM   2850 N  NZ  . LYS A 1 352 ? -12.27900 46.44055 2.84922   1.000 46.99516 ? 352 LYS A NZ  1 
ATOM   2851 N  N   . GLY A 1 353 ? -14.99219 47.12406 -4.58060  1.000 17.53925 ? 353 GLY A N   1 
ATOM   2852 C  CA  . GLY A 1 353 ? -16.00399 46.59474 -5.47534  1.000 16.82876 ? 353 GLY A CA  1 
ATOM   2853 C  C   . GLY A 1 353 ? -16.43306 47.53179 -6.58251  1.000 17.26058 ? 353 GLY A C   1 
ATOM   2854 O  O   . GLY A 1 353 ? -17.55720 47.40556 -7.07596  1.000 18.65161 ? 353 GLY A O   1 
ATOM   2855 N  N   . LYS A 1 354 ? -15.56388 48.46263 -7.00244  1.000 13.93402 ? 354 LYS A N   1 
ATOM   2856 C  CA  . LYS A 1 354 ? -15.89507 49.41840 -8.05836  1.000 20.34405 ? 354 LYS A CA  1 
ATOM   2857 C  C   . LYS A 1 354 ? -15.25713 49.09688 -9.40543  1.000 17.70361 ? 354 LYS A C   1 
ATOM   2858 O  O   . LYS A 1 354 ? -15.52756 49.80491 -10.38048 1.000 18.21430 ? 354 LYS A O   1 
ATOM   2859 C  CB  . LYS A 1 354 ? -15.47370 50.84055 -7.65310  1.000 18.82235 ? 354 LYS A CB  1 
ATOM   2860 C  CG  . LYS A 1 354 ? -16.17081 51.36581 -6.41364  1.000 21.77636 ? 354 LYS A CG  1 
ATOM   2861 C  CD  . LYS A 1 354 ? -17.68033 51.39097 -6.58929  1.000 25.81685 ? 354 LYS A CD  1 
ATOM   2862 C  CE  . LYS A 1 354 ? -18.35272 52.02357 -5.37718  1.000 40.68144 ? 354 LYS A CE  1 
ATOM   2863 N  NZ  . LYS A 1 354 ? -19.82787 52.16901 -5.55080  1.000 54.16471 ? 354 LYS A NZ  1 
ATOM   2864 N  N   . GLY A 1 355 ? -14.40883 48.07657 -9.48314  1.000 15.04275 ? 355 GLY A N   1 
ATOM   2865 C  CA  . GLY A 1 355 ? -13.70217 47.73892 -10.69714 1.000 14.58676 ? 355 GLY A CA  1 
ATOM   2866 C  C   . GLY A 1 355 ? -14.36932 46.61913 -11.47154 1.000 17.73104 ? 355 GLY A C   1 
ATOM   2867 O  O   . GLY A 1 355 ? -15.53645 46.27973 -11.25238 1.000 16.36315 ? 355 GLY A O   1 
ATOM   2868 N  N   . LYS A 1 356 ? -13.60983 46.03240 -12.39408 1.000 14.29535 ? 356 LYS A N   1 
ATOM   2869 C  CA  . LYS A 1 356 ? -14.15698 45.08359 -13.35054 1.000 13.06322 ? 356 LYS A CA  1 
ATOM   2870 C  C   . LYS A 1 356 ? -13.21190 43.90674 -13.47760 1.000 10.67772 ? 356 LYS A C   1 
ATOM   2871 O  O   . LYS A 1 356 ? -12.01041 44.09778 -13.69271 1.000 9.88889  ? 356 LYS A O   1 
ATOM   2872 C  CB  . LYS A 1 356 ? -14.36089 45.73814 -14.72654 1.000 14.31830 ? 356 LYS A CB  1 
ATOM   2873 C  CG  . LYS A 1 356 ? -15.20150 44.91405 -15.70515 1.000 14.51342 ? 356 LYS A CG  1 
ATOM   2874 C  CD  . LYS A 1 356 ? -16.68824 45.03910 -15.40026 1.000 12.51454 ? 356 LYS A CD  1 
ATOM   2875 C  CE  . LYS A 1 356 ? -17.49910 43.91711 -16.05904 1.000 16.41456 ? 356 LYS A CE  1 
ATOM   2876 N  NZ  . LYS A 1 356 ? -17.33746 42.58726 -15.38584 1.000 12.42181 ? 356 LYS A NZ  1 
ATOM   2877 N  N   . ASP A 1 357 ? -13.76258 42.70134 -13.32360 1.000 14.36053 ? 357 ASP A N   1 
ATOM   2878 C  CA  . ASP A 1 357 ? -13.09802 41.43908 -13.61545 1.000 7.98998  ? 357 ASP A CA  1 
ATOM   2879 C  C   . ASP A 1 357 ? -13.59537 40.88776 -14.95389 1.000 9.77895  ? 357 ASP A C   1 
ATOM   2880 O  O   . ASP A 1 357 ? -14.58472 41.35089 -15.52659 1.000 10.77761 ? 357 ASP A O   1 
ATOM   2881 C  CB  . ASP A 1 357 ? -13.34387 40.43423 -12.47756 1.000 11.87040 ? 357 ASP A CB  1 
ATOM   2882 C  CG  . ASP A 1 357 ? -12.13640 39.53156 -12.21545 1.000 11.91025 ? 357 ASP A CG  1 
ATOM   2883 O  OD1 . ASP A 1 357 ? -11.40545 39.19833 -13.18788 1.000 10.88231 ? 357 ASP A OD1 1 
ATOM   2884 O  OD2 . ASP A 1 357 ? -11.91650 39.15609 -11.03704 1.000 12.93761 ? 357 ASP A OD2 1 
ATOM   2885 N  N   . ALA A 1 358 ? -12.88654 39.89439 -15.47374 1.000 10.31798 ? 358 ALA A N   1 
ATOM   2886 C  CA  . ALA A 1 358 ? -13.14569 39.38807 -16.82274 1.000 11.66091 ? 358 ALA A CA  1 
ATOM   2887 C  C   . ALA A 1 358 ? -12.91235 37.88535 -16.84464 1.000 8.66720  ? 358 ALA A C   1 
ATOM   2888 O  O   . ALA A 1 358 ? -11.94885 37.39608 -17.44682 1.000 10.37249 ? 358 ALA A O   1 
ATOM   2889 C  CB  . ALA A 1 358 ? -12.25239 40.10555 -17.83561 1.000 11.05242 ? 358 ALA A CB  1 
ATOM   2890 N  N   . PRO A 1 359 ? -13.80060 37.11512 -16.21807 1.000 9.41551  ? 359 PRO A N   1 
ATOM   2891 C  CA  . PRO A 1 359 ? -13.44631 35.73834 -15.83994 1.000 8.51758  ? 359 PRO A CA  1 
ATOM   2892 C  C   . PRO A 1 359 ? -13.86293 34.63216 -16.79624 1.000 10.65116 ? 359 PRO A C   1 
ATOM   2893 O  O   . PRO A 1 359 ? -13.45954 33.48061 -16.58217 1.000 10.52217 ? 359 PRO A O   1 
ATOM   2894 C  CB  . PRO A 1 359 ? -14.17837 35.56612 -14.50694 1.000 8.91848  ? 359 PRO A CB  1 
ATOM   2895 C  CG  . PRO A 1 359 ? -15.42946 36.40157 -14.67831 1.000 9.40196  ? 359 PRO A CG  1 
ATOM   2896 C  CD  . PRO A 1 359 ? -15.07740 37.54613 -15.61061 1.000 9.91149  ? 359 PRO A CD  1 
ATOM   2897 N  N   . PHE A 1 360 ? -14.67756 34.92447 -17.81092 1.000 7.60399  ? 360 PHE A N   1 
ATOM   2898 C  CA  . PHE A 1 360 ? -15.31063 33.87255 -18.60110 1.000 9.44339  ? 360 PHE A CA  1 
ATOM   2899 C  C   . PHE A 1 360 ? -14.60513 33.69690 -19.94530 1.000 7.05952  ? 360 PHE A C   1 
ATOM   2900 O  O   . PHE A 1 360 ? -13.58593 34.32526 -20.22391 1.000 9.57322  ? 360 PHE A O   1 
ATOM   2901 C  CB  . PHE A 1 360 ? -16.79976 34.18538 -18.78785 1.000 7.93248  ? 360 PHE A CB  1 
ATOM   2902 C  CG  . PHE A 1 360 ? -17.54656 34.34533 -17.49175 1.000 7.67556  ? 360 PHE A CG  1 
ATOM   2903 C  CD1 . PHE A 1 360 ? -17.47513 33.36693 -16.50674 1.000 6.47038  ? 360 PHE A CD1 1 
ATOM   2904 C  CD2 . PHE A 1 360 ? -18.31584 35.47585 -17.25750 1.000 9.73100  ? 360 PHE A CD2 1 
ATOM   2905 C  CE1 . PHE A 1 360 ? -18.16383 33.52090 -15.29544 1.000 10.09618 ? 360 PHE A CE1 1 
ATOM   2906 C  CE2 . PHE A 1 360 ? -19.01839 35.63431 -16.05688 1.000 9.03585  ? 360 PHE A CE2 1 
ATOM   2907 C  CZ  . PHE A 1 360 ? -18.94367 34.66499 -15.07661 1.000 7.37269  ? 360 PHE A CZ  1 
ATOM   2908 N  N   . VAL A 1 361 ? -15.14848 32.81869 -20.80138 1.000 8.47142  ? 361 VAL A N   1 
ATOM   2909 C  CA  . VAL A 1 361 ? -14.62410 32.71002 -22.16423 1.000 8.12138  ? 361 VAL A CA  1 
ATOM   2910 C  C   . VAL A 1 361 ? -15.38400 33.59200 -23.14569 1.000 9.11559  ? 361 VAL A C   1 
ATOM   2911 O  O   . VAL A 1 361 ? -15.00646 33.66227 -24.32502 1.000 11.85391 ? 361 VAL A O   1 
ATOM   2912 C  CB  . VAL A 1 361 ? -14.61256 31.25998 -22.71618 1.000 10.72004 ? 361 VAL A CB  1 
ATOM   2913 C  CG1 . VAL A 1 361 ? -13.85401 30.31211 -21.78374 1.000 9.89071  ? 361 VAL A CG1 1 
ATOM   2914 C  CG2 . VAL A 1 361 ? -16.01164 30.76118 -23.01140 1.000 7.71465  ? 361 VAL A CG2 1 
ATOM   2915 N  N   . PHE A 1 362 ? -16.42296 34.28631 -22.69623 1.000 7.85473  ? 362 PHE A N   1 
ATOM   2916 C  CA  . PHE A 1 362 ? -17.21514 35.17580 -23.53634 1.000 9.58456  ? 362 PHE A CA  1 
ATOM   2917 C  C   . PHE A 1 362 ? -17.10190 36.59892 -23.00427 1.000 9.62203  ? 362 PHE A C   1 
ATOM   2918 O  O   . PHE A 1 362 ? -17.22487 36.82069 -21.79205 1.000 10.13855 ? 362 PHE A O   1 
ATOM   2919 C  CB  . PHE A 1 362 ? -18.68977 34.72811 -23.55987 1.000 8.39311  ? 362 PHE A CB  1 
ATOM   2920 C  CG  . PHE A 1 362 ? -18.89912 33.29909 -24.03402 1.000 10.17429 ? 362 PHE A CG  1 
ATOM   2921 C  CD1 . PHE A 1 362 ? -18.58436 32.92846 -25.33210 1.000 10.47221 ? 362 PHE A CD1 1 
ATOM   2922 C  CD2 . PHE A 1 362 ? -19.42424 32.33668 -23.18141 1.000 10.10035 ? 362 PHE A CD2 1 
ATOM   2923 C  CE1 . PHE A 1 362 ? -18.77714 31.61364 -25.77167 1.000 11.22377 ? 362 PHE A CE1 1 
ATOM   2924 C  CE2 . PHE A 1 362 ? -19.63314 31.02777 -23.61565 1.000 11.81131 ? 362 PHE A CE2 1 
ATOM   2925 C  CZ  . PHE A 1 362 ? -19.29768 30.66769 -24.91882 1.000 10.14709 ? 362 PHE A CZ  1 
ATOM   2926 N  N   . GLY A 1 363 ? -16.88601 37.56303 -23.91333 1.000 9.22724  ? 363 GLY A N   1 
ATOM   2927 C  CA  . GLY A 1 363 ? -16.70907 38.95324 -23.54512 1.000 7.87515  ? 363 GLY A CA  1 
ATOM   2928 C  C   . GLY A 1 363 ? -18.01846 39.65195 -23.21854 1.000 11.21055 ? 363 GLY A C   1 
ATOM   2929 O  O   . GLY A 1 363 ? -19.12914 39.12984 -23.42977 1.000 9.87038  ? 363 GLY A O   1 
ATOM   2930 N  N   . PRO A 1 364 ? -17.90431 40.87593 -22.68735 1.000 9.53632  ? 364 PRO A N   1 
ATOM   2931 C  CA  . PRO A 1 364 ? -19.11301 41.60137 -22.25330 1.000 8.58048  ? 364 PRO A CA  1 
ATOM   2932 C  C   . PRO A 1 364 ? -20.00375 42.01819 -23.40058 1.000 9.05054  ? 364 PRO A C   1 
ATOM   2933 O  O   . PRO A 1 364 ? -21.17543 42.33525 -23.16553 1.000 10.73589 ? 364 PRO A O   1 
ATOM   2934 C  CB  . PRO A 1 364 ? -18.55223 42.82168 -21.51143 1.000 10.70216 ? 364 PRO A CB  1 
ATOM   2935 C  CG  . PRO A 1 364 ? -17.17163 43.02331 -22.13230 1.000 15.76648 ? 364 PRO A CG  1 
ATOM   2936 C  CD  . PRO A 1 364 ? -16.66716 41.65569 -22.48232 1.000 13.07629 ? 364 PRO A CD  1 
ATOM   2937 N  N   . ASP A 1 365 ? -19.49143 42.03530 -24.63181 1.000 6.37612  ? 365 ASP A N   1 
ATOM   2938 C  CA  . ASP A 1 365 ? -20.31099 42.25953 -25.81033 1.000 9.25566  ? 365 ASP A CA  1 
ATOM   2939 C  C   . ASP A 1 365 ? -20.75748 40.95073 -26.44309 1.000 9.54706  ? 365 ASP A C   1 
ATOM   2940 O  O   . ASP A 1 365 ? -21.17600 40.95411 -27.60625 1.000 8.44921  ? 365 ASP A O   1 
ATOM   2941 C  CB  . ASP A 1 365 ? -19.55448 43.11595 -26.83648 1.000 9.35230  ? 365 ASP A CB  1 
ATOM   2942 C  CG  . ASP A 1 365 ? -18.17335 42.56614 -27.15423 1.000 11.68951 ? 365 ASP A CG  1 
ATOM   2943 O  OD1 . ASP A 1 365 ? -17.84404 41.45407 -26.66875 1.000 7.89965  ? 365 ASP A OD1 1 
ATOM   2944 O  OD2 . ASP A 1 365 ? -17.41250 43.23601 -27.89238 1.000 9.06717  ? 365 ASP A OD2 1 
ATOM   2945 N  N   . TYR A 1 366 ? -20.63805 39.82955 -25.71088 1.000 7.47759  ? 366 TYR A N   1 
ATOM   2946 C  CA  . TYR A 1 366 ? -21.07371 38.51319 -26.19255 1.000 8.94917  ? 366 TYR A CA  1 
ATOM   2947 C  C   . TYR A 1 366 ? -20.27377 38.05324 -27.41249 1.000 9.59040  ? 366 TYR A C   1 
ATOM   2948 O  O   . TYR A 1 366 ? -20.78280 37.33002 -28.27302 1.000 10.90635 ? 366 TYR A O   1 
ATOM   2949 C  CB  . TYR A 1 366 ? -22.58127 38.50693 -26.48948 1.000 7.29641  ? 366 TYR A CB  1 
ATOM   2950 C  CG  . TYR A 1 366 ? -23.40107 38.71266 -25.23196 1.000 11.65931 ? 366 TYR A CG  1 
ATOM   2951 C  CD1 . TYR A 1 366 ? -23.75407 39.99319 -24.80789 1.000 9.63213  ? 366 TYR A CD1 1 
ATOM   2952 C  CD2 . TYR A 1 366 ? -23.78911 37.62512 -24.44746 1.000 7.75816  ? 366 TYR A CD2 1 
ATOM   2953 C  CE1 . TYR A 1 366 ? -24.50330 40.18649 -23.64034 1.000 10.45391 ? 366 TYR A CE1 1 
ATOM   2954 C  CE2 . TYR A 1 366 ? -24.53659 37.80241 -23.27991 1.000 10.42729 ? 366 TYR A CE2 1 
ATOM   2955 C  CZ  . TYR A 1 366 ? -24.88872 39.09067 -22.87824 1.000 14.45886 ? 366 TYR A CZ  1 
ATOM   2956 O  OH  . TYR A 1 366 ? -25.62618 39.28705 -21.71785 1.000 15.88359 ? 366 TYR A OH  1 
ATOM   2957 N  N   . LYS A 1 367 ? -19.00956 38.45708 -27.50121 1.000 10.33047 ? 367 LYS A N   1 
ATOM   2958 C  CA  . LYS A 1 367 ? -18.09789 37.92238 -28.50482 1.000 10.44376 ? 367 LYS A CA  1 
ATOM   2959 C  C   . LYS A 1 367 ? -17.05181 37.05971 -27.80783 1.000 13.72687 ? 367 LYS A C   1 
ATOM   2960 O  O   . LYS A 1 367 ? -16.74642 37.26187 -26.62442 1.000 11.81129 ? 367 LYS A O   1 
ATOM   2961 C  CB  . LYS A 1 367 ? -17.43639 39.04952 -29.30441 1.000 11.61480 ? 367 LYS A CB  1 
ATOM   2962 C  CG  . LYS A 1 367 ? -18.44678 39.95554 -30.00195 1.000 10.24986 ? 367 LYS A CG  1 
ATOM   2963 C  CD  . LYS A 1 367 ? -17.78585 41.18867 -30.64305 1.000 13.04642 ? 367 LYS A CD  1 
ATOM   2964 C  CE  . LYS A 1 367 ? -18.82519 42.02262 -31.40429 1.000 13.72469 ? 367 LYS A CE  1 
ATOM   2965 N  NZ  . LYS A 1 367 ? -18.36913 43.42013 -31.67262 1.000 14.09487 ? 367 LYS A NZ  1 
ATOM   2966 N  N   . VAL A 1 368 ? -16.51270 36.08474 -28.53790 1.000 11.92998 ? 368 VAL A N   1 
ATOM   2967 C  CA  . VAL A 1 368 ? -15.67421 35.07022 -27.91180 1.000 10.21055 ? 368 VAL A CA  1 
ATOM   2968 C  C   . VAL A 1 368 ? -14.30149 35.65467 -27.61725 1.000 10.26244 ? 368 VAL A C   1 
ATOM   2969 O  O   . VAL A 1 368 ? -13.75457 36.44272 -28.39959 1.000 10.18622 ? 368 VAL A O   1 
ATOM   2970 C  CB  . VAL A 1 368 ? -15.57878 33.80757 -28.79127 1.000 8.50848  ? 368 VAL A CB  1 
ATOM   2971 C  CG1 . VAL A 1 368 ? -16.95396 33.16683 -28.97024 1.000 9.10993  ? 368 VAL A CG1 1 
ATOM   2972 C  CG2 . VAL A 1 368 ? -14.94685 34.12217 -30.14432 1.000 8.30219  ? 368 VAL A CG2 1 
ATOM   2973 N  N   . LYS A 1 369 ? -13.74792 35.26964 -26.47826 1.000 9.65449  ? 369 LYS A N   1 
ATOM   2974 C  CA  . LYS A 1 369 ? -12.42220 35.69268 -26.04721 1.000 12.23598 ? 369 LYS A CA  1 
ATOM   2975 C  C   . LYS A 1 369 ? -11.38276 34.68655 -26.51020 1.000 11.00803 ? 369 LYS A C   1 
ATOM   2976 O  O   . LYS A 1 369 ? -11.71683 33.60876 -26.99573 1.000 11.81339 ? 369 LYS A O   1 
ATOM   2977 C  CB  . LYS A 1 369 ? -12.40349 35.83439 -24.52467 1.000 8.90013  ? 369 LYS A CB  1 
ATOM   2978 C  CG  . LYS A 1 369 ? -13.40329 36.85494 -24.00097 1.000 8.28709  ? 369 LYS A CG  1 
ATOM   2979 C  CD  . LYS A 1 369 ? -13.64891 36.64682 -22.50509 1.000 6.99248  ? 369 LYS A CD  1 
ATOM   2980 C  CE  . LYS A 1 369 ? -12.38187 36.86462 -21.69796 1.000 8.35261  ? 369 LYS A CE  1 
ATOM   2981 N  NZ  . LYS A 1 369 ? -12.69238 36.92140 -20.22228 1.000 11.25460 ? 369 LYS A NZ  1 
ATOM   2982 N  N   . PRO A 1 370 ? -10.09321 35.00820 -26.39064 1.000 14.83817 ? 370 PRO A N   1 
ATOM   2983 C  CA  . PRO A 1 370 ? -9.08319  33.98913 -26.70618 1.000 9.77654  ? 370 PRO A CA  1 
ATOM   2984 C  C   . PRO A 1 370 ? -9.24935  32.74370 -25.86107 1.000 11.29404 ? 370 PRO A C   1 
ATOM   2985 O  O   . PRO A 1 370 ? -8.97880  31.63742 -26.34254 1.000 12.47953 ? 370 PRO A O   1 
ATOM   2986 C  CB  . PRO A 1 370 ? -7.75187  34.70116 -26.41756 1.000 9.50984  ? 370 PRO A CB  1 
ATOM   2987 C  CG  . PRO A 1 370 ? -8.05295  36.15711 -26.50261 1.000 15.02638 ? 370 PRO A CG  1 
ATOM   2988 C  CD  . PRO A 1 370 ? -9.48733  36.31455 -26.05027 1.000 11.50652 ? 370 PRO A CD  1 
ATOM   2989 N  N   . ALA A 1 371 ? -9.70732  32.88639 -24.61497 1.000 8.00848  ? 371 ALA A N   1 
ATOM   2990 C  CA  . ALA A 1 371 ? -9.95148  31.70838 -23.78255 1.000 10.58447 ? 371 ALA A CA  1 
ATOM   2991 C  C   . ALA A 1 371 ? -10.95899 30.74981 -24.42020 1.000 12.06100 ? 371 ALA A C   1 
ATOM   2992 O  O   . ALA A 1 371 ? -10.85102 29.52712 -24.23883 1.000 8.67948  ? 371 ALA A O   1 
ATOM   2993 C  CB  . ALA A 1 371 ? -10.42869 32.13069 -22.39130 1.000 6.82136  ? 371 ALA A CB  1 
ATOM   2994 N  N   . TYR A 1 372 ? -11.94974 31.27540 -25.14878 1.000 8.07054  ? 372 TYR A N   1 
ATOM   2995 C  CA  . TYR A 1 372 ? -12.89942 30.40577 -25.84979 1.000 10.58869 ? 372 TYR A CA  1 
ATOM   2996 C  C   . TYR A 1 372 ? -12.19066 29.52011 -26.87334 1.000 13.50181 ? 372 TYR A C   1 
ATOM   2997 O  O   . TYR A 1 372 ? -12.36816 28.29314 -26.88606 1.000 10.53237 ? 372 TYR A O   1 
ATOM   2998 C  CB  . TYR A 1 372 ? -13.98094 31.24729 -26.54226 1.000 9.34313  ? 372 TYR A CB  1 
ATOM   2999 C  CG  . TYR A 1 372 ? -14.77991 30.47804 -27.57758 1.000 10.35830 ? 372 TYR A CG  1 
ATOM   3000 C  CD1 . TYR A 1 372 ? -15.88583 29.72420 -27.19921 1.000 8.67232  ? 372 TYR A CD1 1 
ATOM   3001 C  CD2 . TYR A 1 372 ? -14.42016 30.49020 -28.92986 1.000 9.06795  ? 372 TYR A CD2 1 
ATOM   3002 C  CE1 . TYR A 1 372 ? -16.62362 29.01376 -28.12744 1.000 11.20591 ? 372 TYR A CE1 1 
ATOM   3003 C  CE2 . TYR A 1 372 ? -15.14777 29.76589 -29.87476 1.000 9.96497  ? 372 TYR A CE2 1 
ATOM   3004 C  CZ  . TYR A 1 372 ? -16.25357 29.03153 -29.46363 1.000 13.19299 ? 372 TYR A CZ  1 
ATOM   3005 O  OH  . TYR A 1 372 ? -17.00089 28.30420 -30.36956 1.000 11.72045 ? 372 TYR A OH  1 
ATOM   3006 N  N   . TRP A 1 373 ? -11.42160 30.13252 -27.77785 1.000 9.40911  ? 373 TRP A N   1 
ATOM   3007 C  CA  . TRP A 1 373 ? -10.69149 29.34377 -28.76419 1.000 10.68411 ? 373 TRP A CA  1 
ATOM   3008 C  C   . TRP A 1 373 ? -9.77281  28.33945 -28.08278 1.000 13.89205 ? 373 TRP A C   1 
ATOM   3009 O  O   . TRP A 1 373 ? -9.60383  27.21423 -28.56613 1.000 13.51628 ? 373 TRP A O   1 
ATOM   3010 C  CB  . TRP A 1 373 ? -9.89890  30.26604 -29.69365 1.000 11.62094 ? 373 TRP A CB  1 
ATOM   3011 C  CG  . TRP A 1 373 ? -10.80648 31.15765 -30.50187 1.000 15.82316 ? 373 TRP A CG  1 
ATOM   3012 C  CD1 . TRP A 1 373 ? -10.91556 32.52262 -30.41458 1.000 13.25409 ? 373 TRP A CD1 1 
ATOM   3013 C  CD2 . TRP A 1 373 ? -11.74364 30.74389 -31.50571 1.000 12.80893 ? 373 TRP A CD2 1 
ATOM   3014 N  NE1 . TRP A 1 373 ? -11.85601 32.98050 -31.30650 1.000 12.85378 ? 373 TRP A NE1 1 
ATOM   3015 C  CE2 . TRP A 1 373 ? -12.39018 31.91085 -31.97932 1.000 12.07195 ? 373 TRP A CE2 1 
ATOM   3016 C  CE3 . TRP A 1 373 ? -12.10244 29.50089 -32.04889 1.000 13.46624 ? 373 TRP A CE3 1 
ATOM   3017 C  CZ2 . TRP A 1 373 ? -13.36141 31.87522 -32.97677 1.000 10.39056 ? 373 TRP A CZ2 1 
ATOM   3018 C  CZ3 . TRP A 1 373 ? -13.07999 29.46447 -33.05362 1.000 14.98664 ? 373 TRP A CZ3 1 
ATOM   3019 C  CH2 . TRP A 1 373 ? -13.69656 30.64449 -33.50177 1.000 15.76301 ? 373 TRP A CH2 1 
ATOM   3020 N  N   . ALA A 1 374 ? -9.19359  28.72365 -26.94141 1.000 10.86088 ? 374 ALA A N   1 
ATOM   3021 C  CA  . ALA A 1 374 ? -8.32318  27.82213 -26.20050 1.000 15.12986 ? 374 ALA A CA  1 
ATOM   3022 C  C   . ALA A 1 374 ? -9.04633  26.55704 -25.74920 1.000 14.49114 ? 374 ALA A C   1 
ATOM   3023 O  O   . ALA A 1 374 ? -8.40734  25.51917 -25.58424 1.000 14.24538 ? 374 ALA A O   1 
ATOM   3024 C  CB  . ALA A 1 374 ? -7.72767  28.54106 -24.98396 1.000 13.17815 ? 374 ALA A CB  1 
ATOM   3025 N  N   . ILE A 1 375 ? -10.35857 26.60055 -25.52734 1.000 10.04795 ? 375 ILE A N   1 
ATOM   3026 C  CA  . ILE A 1 375 ? -11.04080 25.41801 -25.00660 1.000 12.58509 ? 375 ILE A CA  1 
ATOM   3027 C  C   . ILE A 1 375 ? -11.99771 24.79933 -26.00489 1.000 11.44031 ? 375 ILE A C   1 
ATOM   3028 O  O   . ILE A 1 375 ? -12.48214 23.68018 -25.76149 1.000 10.87981 ? 375 ILE A O   1 
ATOM   3029 C  CB  . ILE A 1 375 ? -11.76513 25.69901 -23.66711 1.000 11.15555 ? 375 ILE A CB  1 
ATOM   3030 C  CG1 . ILE A 1 375 ? -12.97218 26.61659 -23.84258 1.000 12.40563 ? 375 ILE A CG1 1 
ATOM   3031 C  CG2 . ILE A 1 375 ? -10.80901 26.27752 -22.60859 1.000 6.95619  ? 375 ILE A CG2 1 
ATOM   3032 C  CD1 . ILE A 1 375 ? -13.80515 26.67028 -22.58145 1.000 11.09653 ? 375 ILE A CD1 1 
ATOM   3033 N  N   . ILE A 1 376 ? -12.25391 25.45214 -27.13795 1.000 12.08631 ? 376 ILE A N   1 
ATOM   3034 C  CA  . ILE A 1 376 ? -13.10455 24.82738 -28.13573 1.000 10.81550 ? 376 ILE A CA  1 
ATOM   3035 C  C   . ILE A 1 376 ? -12.31030 23.88565 -29.02987 1.000 13.65966 ? 376 ILE A C   1 
ATOM   3036 O  O   . ILE A 1 376 ? -12.90233 22.99637 -29.65030 1.000 12.62697 ? 376 ILE A O   1 
ATOM   3037 C  CB  . ILE A 1 376 ? -13.84794 25.87676 -28.98004 1.000 9.39908  ? 376 ILE A CB  1 
ATOM   3038 C  CG1 . ILE A 1 376 ? -15.10511 25.26797 -29.62542 1.000 12.04170 ? 376 ILE A CG1 1 
ATOM   3039 C  CG2 . ILE A 1 376 ? -12.93389 26.46467 -30.05652 1.000 11.07299 ? 376 ILE A CG2 1 
ATOM   3040 C  CD1 . ILE A 1 376 ? -16.24870 24.98524 -28.63779 1.000 11.27257 ? 376 ILE A CD1 1 
ATOM   3041 N  N   . ASP A 1 377 ? -10.99009 24.04467 -29.11232 1.000 13.22764 ? 377 ASP A N   1 
ATOM   3042 C  CA  . ASP A 1 377 ? -10.19353 23.21986 -30.00680 1.000 13.86721 ? 377 ASP A CA  1 
ATOM   3043 C  C   . ASP A 1 377 ? -9.87022  21.87834 -29.34003 1.000 21.82334 ? 377 ASP A C   1 
ATOM   3044 O  O   . ASP A 1 377 ? -10.32444 21.57637 -28.22776 1.000 15.33487 ? 377 ASP A O   1 
ATOM   3045 C  CB  . ASP A 1 377 ? -8.93379  23.97824 -30.45034 1.000 16.83609 ? 377 ASP A CB  1 
ATOM   3046 C  CG  . ASP A 1 377 ? -7.92772  24.21949 -29.31447 1.000 19.49017 ? 377 ASP A CG  1 
ATOM   3047 O  OD1 . ASP A 1 377 ? -8.09398  23.66236 -28.21702 1.000 19.84414 ? 377 ASP A OD1 1 
ATOM   3048 O  OD2 . ASP A 1 377 ? -6.95083  24.97258 -29.52070 1.000 19.74613 ? 377 ASP A OD2 1 
ATOM   3049 N  N   . HIS A 1 378 ? -9.05644  21.06486 -30.02156 1.000 17.25067 ? 378 HIS A N   1 
ATOM   3050 C  CA  . HIS A 1 378 ? -8.64406  19.76632 -29.50078 1.000 23.26738 ? 378 HIS A CA  1 
ATOM   3051 C  C   . HIS A 1 378 ? -7.12931  19.67064 -29.34704 1.000 21.35876 ? 378 HIS A C   1 
ATOM   3052 O  O   . HIS A 1 378 ? -6.55429  18.60711 -29.57174 1.000 27.06131 ? 378 HIS A O   1 
ATOM   3053 C  CB  . HIS A 1 378 ? -9.15656  18.62870 -30.38889 1.000 18.99939 ? 378 HIS A CB  1 
ATOM   3054 C  CG  . HIS A 1 378 ? -10.63370 18.64712 -30.58890 1.000 18.08033 ? 378 HIS A CG  1 
ATOM   3055 N  ND1 . HIS A 1 378 ? -11.48990 17.84254 -29.86823 1.000 17.58707 ? 378 HIS A ND1 1 
ATOM   3056 C  CD2 . HIS A 1 378 ? -11.41178 19.39158 -31.40634 1.000 16.94112 ? 378 HIS A CD2 1 
ATOM   3057 C  CE1 . HIS A 1 378 ? -12.73208 18.07773 -30.24691 1.000 21.94349 ? 378 HIS A CE1 1 
ATOM   3058 N  NE2 . HIS A 1 378 ? -12.71278 19.01611 -31.17655 1.000 22.59227 ? 378 HIS A NE2 1 
ATOM   3059 N  N   . LYS A 1 379 ? -6.47699  20.77450 -28.99346 1.000 21.54143 ? 379 LYS A N   1 
ATOM   3060 C  CA  . LYS A 1 379 ? -5.03655  20.78618 -28.72801 1.000 25.73645 ? 379 LYS A CA  1 
ATOM   3061 C  C   . LYS A 1 379 ? -4.79620  21.27838 -27.31950 1.000 30.25875 ? 379 LYS A C   1 
ATOM   3062 O  O   . LYS A 1 379 ? -5.74341  21.58667 -26.60485 1.000 23.06061 ? 379 LYS A O   1 
ATOM   3063 C  CB  . LYS A 1 379 ? -4.27410  21.68167 -29.70007 1.000 25.50140 ? 379 LYS A CB  1 
ATOM   3064 C  CG  . LYS A 1 379 ? -4.69432  21.56022 -31.13634 1.000 36.03710 ? 379 LYS A CG  1 
ATOM   3065 C  CD  . LYS A 1 379 ? -3.95031  22.55845 -32.01831 1.000 44.27568 ? 379 LYS A CD  1 
ATOM   3066 C  CE  . LYS A 1 379 ? -4.22534  24.00860 -31.59814 1.000 47.32681 ? 379 LYS A CE  1 
ATOM   3067 N  NZ  . LYS A 1 379 ? -5.54112  24.56276 -32.07202 1.000 48.51939 ? 379 LYS A NZ  1 
ATOM   3068 O  OXT . LYS A 1 379 ? -3.65661  21.39309 -26.87563 1.000 40.62726 ? 379 LYS A OXT 1 
HETATM 3069 O  O1  . PG4 B 2 .   ? -3.47381  33.34484 -3.70803  1.000 41.36255 ? 401 PG4 A O1  1 
HETATM 3070 C  C1  . PG4 B 2 .   ? -4.80480  33.62356 -3.37240  1.000 34.56930 ? 401 PG4 A C1  1 
HETATM 3071 C  C2  . PG4 B 2 .   ? -5.16990  33.12757 -1.96610  1.000 41.81522 ? 401 PG4 A C2  1 
HETATM 3072 O  O2  . PG4 B 2 .   ? -5.79536  31.86556 -2.02721  1.000 47.68946 ? 401 PG4 A O2  1 
HETATM 3073 C  C3  . PG4 B 2 .   ? -7.11708  31.81775 -1.54759  1.000 37.02301 ? 401 PG4 A C3  1 
HETATM 3074 C  C4  . PG4 B 2 .   ? -8.07981  32.49075 -2.52838  1.000 36.56910 ? 401 PG4 A C4  1 
HETATM 3075 O  O3  . PG4 B 2 .   ? -9.30694  32.62865 -1.87245  1.000 39.68710 ? 401 PG4 A O3  1 
HETATM 3076 C  C5  . PG4 B 2 .   ? -10.19229 33.56969 -2.41543  1.000 31.17336 ? 401 PG4 A C5  1 
HETATM 3077 C  C6  . PG4 B 2 .   ? -11.27638 33.84290 -1.37212  1.000 37.81063 ? 401 PG4 A C6  1 
HETATM 3078 O  O4  . PG4 B 2 .   ? -10.66668 33.97962 -0.11444  1.000 47.36101 ? 401 PG4 A O4  1 
HETATM 3079 C  C7  . PG4 B 2 .   ? -10.98588 32.97011 0.80297   1.000 41.90401 ? 401 PG4 A C7  1 
HETATM 3080 C  C8  . PG4 B 2 .   ? -10.07828 33.09765 2.02615   1.000 45.73056 ? 401 PG4 A C8  1 
HETATM 3081 O  O5  . PG4 B 2 .   ? -10.41772 34.27225 2.71121   1.000 48.53457 ? 401 PG4 A O5  1 
HETATM 3082 CL CL  . CL  C 3 .   ? -23.53428 38.66833 -9.25578  1.000 22.48921 ? 402 CL  A CL  1 
HETATM 3083 CL CL  . CL  D 3 .   ? -15.38024 12.24504 -27.70317 1.000 15.09297 ? 403 CL  A CL  1 
HETATM 3084 ZN ZN  . ZN  E 4 .   ? -25.25615 38.10786 -10.55901 1.000 19.36917 ? 404 ZN  A ZN  1 
HETATM 3085 ZN ZN  . ZN  F 4 .   ? -23.14121 29.36117 -3.04559  1.000 27.65761 ? 405 ZN  A ZN  1 
HETATM 3086 ZN ZN  . ZN  G 4 .   ? -26.89565 22.24550 -26.42569 1.000 14.12671 ? 406 ZN  A ZN  1 
HETATM 3087 ZN ZN  . ZN  H 4 .   ? -14.53494 16.36255 -29.89926 1.000 82.26284 ? 407 ZN  A ZN  1 
HETATM 3088 ZN ZN  . ZN  I 4 .   ? -14.58967 12.02316 -25.59040 1.000 13.93958 ? 408 ZN  A ZN  1 
HETATM 3089 ZN ZN  . ZN  J 4 .   ? -14.11472 19.82384 -32.54191 1.000 50.22335 ? 409 ZN  A ZN  1 
HETATM 3090 ZN ZN  . ZN  K 4 .   ? -7.08599  23.62127 -25.90539 1.000 33.46723 ? 410 ZN  A ZN  1 
HETATM 3091 O  O   . HOH L 5 .   ? -39.83725 18.76068 8.45599   1.000 46.07652 ? 501 HOH A O   1 
HETATM 3092 O  O   . HOH L 5 .   ? -9.07849  59.27706 -6.68576  1.000 30.24690 ? 502 HOH A O   1 
HETATM 3093 O  O   . HOH L 5 .   ? -1.32565  43.16792 -2.20527  1.000 33.65017 ? 503 HOH A O   1 
HETATM 3094 O  O   . HOH L 5 .   ? -17.63941 12.81649 -17.15197 1.000 7.34158  ? 504 HOH A O   1 
HETATM 3095 O  O   . HOH L 5 .   ? -9.94244  45.25083 -21.82245 1.000 25.51025 ? 505 HOH A O   1 
HETATM 3096 O  O   . HOH L 5 .   ? -12.66222 53.08234 -8.94741  1.000 19.83977 ? 506 HOH A O   1 
HETATM 3097 O  O   . HOH L 5 .   ? -47.33559 33.69528 5.22543   1.000 35.72109 ? 507 HOH A O   1 
HETATM 3098 O  O   . HOH L 5 .   ? -23.31073 6.96670  2.59348   1.000 32.05169 ? 508 HOH A O   1 
HETATM 3099 O  O   . HOH L 5 .   ? 0.61603   34.02616 -21.20216 1.000 30.82602 ? 509 HOH A O   1 
HETATM 3100 O  O   . HOH L 5 .   ? -27.60445 41.04579 -22.38683 1.000 24.96388 ? 510 HOH A O   1 
HETATM 3101 O  O   . HOH L 5 .   ? -40.38922 35.55683 -10.29383 1.000 39.64769 ? 511 HOH A O   1 
HETATM 3102 O  O   . HOH L 5 .   ? -33.17051 29.54618 24.31848  1.000 27.67451 ? 512 HOH A O   1 
HETATM 3103 O  O   . HOH L 5 .   ? -4.67878  30.07879 -0.81385  1.000 44.27351 ? 513 HOH A O   1 
HETATM 3104 O  O   . HOH L 5 .   ? -35.43308 10.23146 -6.69639  1.000 27.68896 ? 514 HOH A O   1 
HETATM 3105 O  O   . HOH L 5 .   ? -9.17912  35.46525 -30.35870 1.000 23.67043 ? 515 HOH A O   1 
HETATM 3106 O  O   . HOH L 5 .   ? -26.89101 38.94141 -9.88699  1.000 21.31469 ? 516 HOH A O   1 
HETATM 3107 O  O   . HOH L 5 .   ? -25.04850 17.44553 -15.59458 1.000 17.35219 ? 517 HOH A O   1 
HETATM 3108 O  O   . HOH L 5 .   ? -24.03292 12.32070 15.20803  1.000 37.80968 ? 518 HOH A O   1 
HETATM 3109 O  O   . HOH L 5 .   ? -11.703   14.352   -24.159   1.000 16.46807 ? 519 HOH A O   1 
HETATM 3110 O  O   . HOH L 5 .   ? -25.32215 32.85757 -4.03438  1.000 24.57694 ? 520 HOH A O   1 
HETATM 3111 O  O   . HOH L 5 .   ? -1.52872  47.95375 -16.25152 1.000 28.93541 ? 521 HOH A O   1 
HETATM 3112 O  O   . HOH L 5 .   ? -29.31822 30.43873 -29.25726 1.000 24.14973 ? 522 HOH A O   1 
HETATM 3113 O  O   . HOH L 5 .   ? -26.61472 41.94105 -17.44841 1.000 34.10678 ? 523 HOH A O   1 
HETATM 3114 O  O   . HOH L 5 .   ? -13.92486 22.29242 -31.82077 1.000 26.31818 ? 524 HOH A O   1 
HETATM 3115 O  O   . HOH L 5 .   ? -2.26717  43.63650 -15.21757 1.000 37.77985 ? 525 HOH A O   1 
HETATM 3116 O  O   . HOH L 5 .   ? -0.79942  25.15912 -12.93190 1.000 28.47717 ? 526 HOH A O   1 
HETATM 3117 O  O   . HOH L 5 .   ? -4.62196  11.73292 -12.96677 1.000 17.74783 ? 527 HOH A O   1 
HETATM 3118 O  O   . HOH L 5 .   ? -22.50929 26.18505 8.29467   1.000 20.34913 ? 528 HOH A O   1 
HETATM 3119 O  O   . HOH L 5 .   ? -31.27259 32.24369 23.78547  1.000 34.30627 ? 529 HOH A O   1 
HETATM 3120 O  O   . HOH L 5 .   ? -18.88974 25.36805 18.42594  1.000 30.02549 ? 530 HOH A O   1 
HETATM 3121 O  O   . HOH L 5 .   ? -14.67036 44.15470 -2.21261  1.000 18.08942 ? 531 HOH A O   1 
HETATM 3122 O  O   . HOH L 5 .   ? -18.13014 31.19863 -1.84443  1.000 29.46737 ? 532 HOH A O   1 
HETATM 3123 O  O   . HOH L 5 .   ? 2.01268   52.77485 -6.31510  1.000 23.84111 ? 533 HOH A O   1 
HETATM 3124 O  O   . HOH L 5 .   ? -9.06592  22.14554 -26.09362 1.000 16.23780 ? 534 HOH A O   1 
HETATM 3125 O  O   . HOH L 5 .   ? -7.15181  11.22115 5.61245   1.000 33.91875 ? 535 HOH A O   1 
HETATM 3126 O  O   . HOH L 5 .   ? -15.51843 21.57086 16.67497  1.000 42.60164 ? 536 HOH A O   1 
HETATM 3127 O  O   . HOH L 5 .   ? -9.99181  27.00828 -5.59765  1.000 22.50338 ? 537 HOH A O   1 
HETATM 3128 O  O   . HOH L 5 .   ? -45.960   33.464   -9.922    1.000 18.07361 ? 538 HOH A O   1 
HETATM 3129 O  O   . HOH L 5 .   ? -26.34738 39.19100 -18.52664 1.000 19.00460 ? 539 HOH A O   1 
HETATM 3130 O  O   . HOH L 5 .   ? -9.35355  32.23416 -38.23406 1.000 39.92285 ? 540 HOH A O   1 
HETATM 3131 O  O   . HOH L 5 .   ? -32.82110 9.62856  4.72102   1.000 21.35619 ? 541 HOH A O   1 
HETATM 3132 O  O   . HOH L 5 .   ? -24.58316 17.19928 16.52038  1.000 26.96629 ? 542 HOH A O   1 
HETATM 3133 O  O   . HOH L 5 .   ? -23.15094 43.83622 -23.85636 1.000 21.56968 ? 543 HOH A O   1 
HETATM 3134 O  O   . HOH L 5 .   ? -3.59791  41.21667 -5.45537  1.000 22.23647 ? 544 HOH A O   1 
HETATM 3135 O  O   . HOH L 5 .   ? -32.97679 15.65316 22.83155  1.000 33.40435 ? 545 HOH A O   1 
HETATM 3136 O  O   . HOH L 5 .   ? -31.94169 37.60714 -7.98075  1.000 31.94198 ? 546 HOH A O   1 
HETATM 3137 O  O   . HOH L 5 .   ? -27.54996 24.02518 -25.63482 1.000 8.94342  ? 547 HOH A O   1 
HETATM 3138 O  O   . HOH L 5 .   ? -11.48252 30.77334 -4.16037  1.000 17.75252 ? 548 HOH A O   1 
HETATM 3139 O  O   . HOH L 5 .   ? -18.63115 39.33139 -2.71281  1.000 17.43353 ? 549 HOH A O   1 
HETATM 3140 O  O   . HOH L 5 .   ? -5.58568  25.10631 -27.32244 1.000 18.28756 ? 550 HOH A O   1 
HETATM 3141 O  O   . HOH L 5 .   ? -24.71748 23.23823 21.81453  1.000 36.54513 ? 551 HOH A O   1 
HETATM 3142 O  O   . HOH L 5 .   ? -42.87934 16.85806 -6.94440  1.000 26.70433 ? 552 HOH A O   1 
HETATM 3143 O  O   . HOH L 5 .   ? -8.55671  44.06750 -2.57139  1.000 16.69881 ? 553 HOH A O   1 
HETATM 3144 O  O   . HOH L 5 .   ? -21.83801 27.05558 5.66270   1.000 18.42687 ? 554 HOH A O   1 
HETATM 3145 O  O   . HOH L 5 .   ? -24.65808 31.42735 -36.70896 1.000 44.13676 ? 555 HOH A O   1 
HETATM 3146 O  O   . HOH L 5 .   ? -44.19529 29.73476 -10.20682 1.000 16.07383 ? 556 HOH A O   1 
HETATM 3147 O  O   . HOH L 5 .   ? 2.15266   20.37337 -5.92696  1.000 22.80570 ? 557 HOH A O   1 
HETATM 3148 O  O   . HOH L 5 .   ? -2.95758  22.62928 -2.64244  1.000 24.49217 ? 558 HOH A O   1 
HETATM 3149 O  O   . HOH L 5 .   ? -21.55165 11.22677 -28.48391 1.000 25.45380 ? 559 HOH A O   1 
HETATM 3150 O  O   . HOH L 5 .   ? -29.28571 30.21028 -5.61176  1.000 14.00476 ? 560 HOH A O   1 
HETATM 3151 O  O   . HOH L 5 .   ? -11.22587 23.02855 -10.62723 1.000 18.57377 ? 561 HOH A O   1 
HETATM 3152 O  O   . HOH L 5 .   ? -13.44778 26.66169 10.96779  1.000 24.02070 ? 562 HOH A O   1 
HETATM 3153 O  O   . HOH L 5 .   ? -18.46261 32.36416 1.92938   1.000 34.56100 ? 563 HOH A O   1 
HETATM 3154 O  O   . HOH L 5 .   ? -28.84589 26.87646 21.94400  1.000 28.74166 ? 564 HOH A O   1 
HETATM 3155 O  O   . HOH L 5 .   ? -25.38125 19.45012 -14.38693 1.000 21.78526 ? 565 HOH A O   1 
HETATM 3156 O  O   . HOH L 5 .   ? -34.06087 41.03053 -18.62368 1.000 25.66638 ? 566 HOH A O   1 
HETATM 3157 O  O   . HOH L 5 .   ? -24.83472 32.09184 9.66727   1.000 32.00265 ? 567 HOH A O   1 
HETATM 3158 O  O   . HOH L 5 .   ? -44.49985 19.71004 0.00000   0.50  8.93833  ? 568 HOH A O   1 
HETATM 3159 O  O   . HOH L 5 .   ? -15.74151 26.91422 3.49294   1.000 14.16207 ? 569 HOH A O   1 
HETATM 3160 O  O   . HOH L 5 .   ? -17.64948 46.85213 -9.80587  1.000 17.82147 ? 570 HOH A O   1 
HETATM 3161 O  O   . HOH L 5 .   ? -8.99903  8.68474  -7.80020  1.000 27.18282 ? 571 HOH A O   1 
HETATM 3162 O  O   . HOH L 5 .   ? -23.11074 36.43421 -16.37279 1.000 10.67898 ? 572 HOH A O   1 
HETATM 3163 O  O   . HOH L 5 .   ? -19.55413 45.44690 -13.24646 1.000 17.18924 ? 573 HOH A O   1 
HETATM 3164 O  O   . HOH L 5 .   ? -44.49985 33.48253 0.00000   0.50  29.73077 ? 574 HOH A O   1 
HETATM 3165 O  O   . HOH L 5 .   ? -26.90576 7.99474  -5.17659  1.000 27.94506 ? 575 HOH A O   1 
HETATM 3166 O  O   . HOH L 5 .   ? -34.92818 37.59679 -7.36996  1.000 35.86075 ? 576 HOH A O   1 
HETATM 3167 O  O   . HOH L 5 .   ? -6.56766  48.44305 -8.00636  1.000 12.63063 ? 577 HOH A O   1 
HETATM 3168 O  O   . HOH L 5 .   ? -24.36052 30.27193 -35.07559 1.000 60.46145 ? 578 HOH A O   1 
HETATM 3169 O  O   . HOH L 5 .   ? -19.80642 23.60596 10.07407  1.000 17.19609 ? 579 HOH A O   1 
HETATM 3170 O  O   . HOH L 5 .   ? -25.91839 8.42154  -1.65209  1.000 22.02139 ? 580 HOH A O   1 
HETATM 3171 O  O   . HOH L 5 .   ? -3.83603  43.38200 -9.72755  1.000 15.95856 ? 581 HOH A O   1 
HETATM 3172 O  O   . HOH L 5 .   ? -22.91214 7.74515  -4.41155  1.000 30.39091 ? 582 HOH A O   1 
HETATM 3173 O  O   . HOH L 5 .   ? -37.36778 32.95874 -21.43001 1.000 27.84553 ? 583 HOH A O   1 
HETATM 3174 O  O   . HOH L 5 .   ? -2.62112  33.55829 -9.44210  1.000 23.40207 ? 584 HOH A O   1 
HETATM 3175 O  O   . HOH L 5 .   ? -28.90480 32.21547 17.38429  1.000 23.93164 ? 585 HOH A O   1 
HETATM 3176 O  O   . HOH L 5 .   ? -4.96372  50.07325 -17.78663 1.000 15.37836 ? 586 HOH A O   1 
HETATM 3177 O  O   . HOH L 5 .   ? -21.62425 9.39523  -6.91983  1.000 29.25805 ? 587 HOH A O   1 
HETATM 3178 O  O   . HOH L 5 .   ? -8.67263  27.52255 2.09161   1.000 20.79638 ? 588 HOH A O   1 
HETATM 3179 O  O   . HOH L 5 .   ? -1.52438  37.31862 -15.50127 1.000 21.07379 ? 589 HOH A O   1 
HETATM 3180 O  O   . HOH L 5 .   ? -1.12300  16.01090 -9.40921  1.000 25.32353 ? 590 HOH A O   1 
HETATM 3181 O  O   . HOH L 5 .   ? -43.37769 21.55723 -1.85923  1.000 12.42591 ? 591 HOH A O   1 
HETATM 3182 O  O   . HOH L 5 .   ? -40.91505 22.97654 10.91353  1.000 18.57276 ? 592 HOH A O   1 
HETATM 3183 O  O   . HOH L 5 .   ? -3.85600  14.35841 3.06452   1.000 21.80718 ? 593 HOH A O   1 
HETATM 3184 O  O   . HOH L 5 .   ? -38.61152 30.74058 -17.46604 1.000 20.95008 ? 594 HOH A O   1 
HETATM 3185 O  O   . HOH L 5 .   ? -43.36572 11.54327 -8.22598  1.000 43.74282 ? 595 HOH A O   1 
HETATM 3186 O  O   . HOH L 5 .   ? -16.40623 6.37262  3.65151   1.000 31.10107 ? 596 HOH A O   1 
HETATM 3187 O  O   . HOH L 5 .   ? -40.63106 25.45880 9.68530   1.000 13.67865 ? 597 HOH A O   1 
HETATM 3188 O  O   . HOH L 5 .   ? -28.04197 24.30190 21.05556  1.000 21.92470 ? 598 HOH A O   1 
HETATM 3189 O  O   . HOH L 5 .   ? -40.49545 26.15480 14.13269  1.000 19.95607 ? 599 HOH A O   1 
HETATM 3190 O  O   . HOH L 5 .   ? -19.97220 12.34400 -29.76191 1.000 24.34660 ? 600 HOH A O   1 
HETATM 3191 O  O   . HOH L 5 .   ? -24.65593 9.28692  12.05990  1.000 34.18699 ? 601 HOH A O   1 
HETATM 3192 O  O   . HOH L 5 .   ? -11.53619 32.21665 5.83578   1.000 42.51398 ? 602 HOH A O   1 
HETATM 3193 O  O   . HOH L 5 .   ? -12.94568 6.40230  -12.97047 1.000 39.03504 ? 603 HOH A O   1 
HETATM 3194 O  O   . HOH L 5 .   ? -37.98980 32.12740 14.45516  1.000 17.56570 ? 604 HOH A O   1 
HETATM 3195 O  O   . HOH L 5 .   ? -18.42521 11.21903 -12.70998 1.000 18.52812 ? 605 HOH A O   1 
HETATM 3196 O  O   . HOH L 5 .   ? -24.80717 37.31004 -33.41879 1.000 32.30684 ? 606 HOH A O   1 
HETATM 3197 O  O   . HOH L 5 .   ? -45.29205 14.81908 2.85338   1.000 11.01256 ? 607 HOH A O   1 
HETATM 3198 O  O   . HOH L 5 .   ? -37.45483 31.52820 -5.86844  1.000 16.99181 ? 608 HOH A O   1 
HETATM 3199 O  O   . HOH L 5 .   ? -18.30836 34.76148 -11.94890 1.000 11.17564 ? 609 HOH A O   1 
HETATM 3200 O  O   . HOH L 5 .   ? -35.41668 36.99353 0.65376   1.000 26.97271 ? 610 HOH A O   1 
HETATM 3201 O  O   . HOH L 5 .   ? -14.79692 41.16015 -34.13143 1.000 20.59485 ? 611 HOH A O   1 
HETATM 3202 O  O   . HOH L 5 .   ? -18.43007 30.41252 -36.85592 1.000 36.91393 ? 612 HOH A O   1 
HETATM 3203 O  O   . HOH L 5 .   ? -11.23707 52.96858 -19.06670 1.000 28.11165 ? 613 HOH A O   1 
HETATM 3204 O  O   . HOH L 5 .   ? -12.48328 40.29868 -8.63495  1.000 9.31582  ? 614 HOH A O   1 
HETATM 3205 O  O   . HOH L 5 .   ? -11.95437 43.21919 -0.31743  1.000 21.57930 ? 615 HOH A O   1 
HETATM 3206 O  O   . HOH L 5 .   ? -44.18783 22.44718 4.04921   1.000 11.13502 ? 616 HOH A O   1 
HETATM 3207 O  O   . HOH L 5 .   ? -15.48307 10.14374 -9.59509  1.000 25.36430 ? 617 HOH A O   1 
HETATM 3208 O  O   . HOH L 5 .   ? -11.37813 58.05675 -7.71230  1.000 31.49740 ? 618 HOH A O   1 
HETATM 3209 O  O   . HOH L 5 .   ? -0.94083  14.24542 -18.15834 1.000 38.95986 ? 619 HOH A O   1 
HETATM 3210 O  O   . HOH L 5 .   ? -26.05666 36.81141 3.26049   1.000 33.32813 ? 620 HOH A O   1 
HETATM 3211 O  O   . HOH L 5 .   ? -5.52921  35.75862 -11.73242 1.000 13.49671 ? 621 HOH A O   1 
HETATM 3212 O  O   . HOH L 5 .   ? -18.98620 22.40561 -30.87450 1.000 14.61486 ? 622 HOH A O   1 
HETATM 3213 O  O   . HOH L 5 .   ? -6.77355  15.91187 -21.87209 1.000 18.70115 ? 623 HOH A O   1 
HETATM 3214 O  O   . HOH L 5 .   ? -8.63386  9.81749  -14.59450 1.000 27.53406 ? 624 HOH A O   1 
HETATM 3215 O  O   . HOH L 5 .   ? -24.54944 21.14451 -34.10290 1.000 24.65197 ? 625 HOH A O   1 
HETATM 3216 O  O   . HOH L 5 .   ? -41.70412 25.86451 7.22141   1.000 10.29632 ? 626 HOH A O   1 
HETATM 3217 O  O   . HOH L 5 .   ? -38.38462 25.38506 7.76447   1.000 13.79778 ? 627 HOH A O   1 
HETATM 3218 O  O   . HOH L 5 .   ? -29.57562 22.40959 -23.23761 1.000 12.99616 ? 628 HOH A O   1 
HETATM 3219 O  O   . HOH L 5 .   ? -25.06862 24.10228 -13.59227 1.000 12.14943 ? 629 HOH A O   1 
HETATM 3220 O  O   . HOH L 5 .   ? -17.15785 15.26726 -26.03433 1.000 14.43918 ? 630 HOH A O   1 
HETATM 3221 O  O   . HOH L 5 .   ? -42.68811 13.17257 0.38886   1.000 22.94837 ? 631 HOH A O   1 
HETATM 3222 O  O   . HOH L 5 .   ? -36.41668 11.95067 -8.63359  1.000 37.14575 ? 632 HOH A O   1 
HETATM 3223 O  O   . HOH L 5 .   ? -6.58083  18.58447 7.15075   1.000 30.30278 ? 633 HOH A O   1 
HETATM 3224 O  O   . HOH L 5 .   ? -34.53165 19.44481 -17.81894 1.000 21.79142 ? 634 HOH A O   1 
HETATM 3225 O  O   . HOH L 5 .   ? -30.15193 26.42589 -8.22487  1.000 13.67151 ? 635 HOH A O   1 
HETATM 3226 O  O   . HOH L 5 .   ? -12.39388 19.22845 10.31060  1.000 27.83293 ? 636 HOH A O   1 
HETATM 3227 O  O   . HOH L 5 .   ? -20.08982 10.11963 -22.45588 1.000 18.13993 ? 637 HOH A O   1 
HETATM 3228 O  O   . HOH L 5 .   ? -37.76540 36.64300 8.56879   1.000 29.74131 ? 638 HOH A O   1 
HETATM 3229 O  O   . HOH L 5 .   ? -25.86935 23.35881 -27.83785 1.000 8.99048  ? 639 HOH A O   1 
HETATM 3230 O  O   . HOH L 5 .   ? -30.30564 33.49602 -9.02541  1.000 16.10836 ? 640 HOH A O   1 
HETATM 3231 O  O   . HOH L 5 .   ? -23.57994 15.48257 -21.95523 1.000 25.30059 ? 641 HOH A O   1 
HETATM 3232 O  O   . HOH L 5 .   ? -43.84738 14.67144 -7.64567  1.000 33.67492 ? 642 HOH A O   1 
HETATM 3233 O  O   . HOH L 5 .   ? -5.91431  58.44313 -3.89659  1.000 31.54472 ? 643 HOH A O   1 
HETATM 3234 O  O   . HOH L 5 .   ? 1.85865   22.45588 -7.61716  1.000 18.63748 ? 644 HOH A O   1 
HETATM 3235 O  O   . HOH L 5 .   ? -33.78800 19.15943 26.16401  1.000 35.46833 ? 645 HOH A O   1 
HETATM 3236 O  O   . HOH L 5 .   ? -19.88224 31.34945 -19.13272 1.000 7.91936  ? 646 HOH A O   1 
HETATM 3237 O  O   . HOH L 5 .   ? -21.96068 24.37806 20.76197  1.000 46.34354 ? 647 HOH A O   1 
HETATM 3238 O  O   . HOH L 5 .   ? -32.15211 18.09729 -13.56951 1.000 10.22913 ? 648 HOH A O   1 
HETATM 3239 O  O   . HOH L 5 .   ? 0.00000   14.22044 0.00000   0.50  27.74127 ? 649 HOH A O   1 
HETATM 3240 O  O   . HOH L 5 .   ? -21.57017 19.04356 -22.46214 1.000 9.90708  ? 650 HOH A O   1 
HETATM 3241 O  O   . HOH L 5 .   ? -8.00337  10.07952 -19.34613 1.000 29.89405 ? 651 HOH A O   1 
HETATM 3242 O  O   . HOH L 5 .   ? -40.68054 17.48304 -8.85276  1.000 18.67488 ? 652 HOH A O   1 
HETATM 3243 O  O   . HOH L 5 .   ? -7.71090  22.66398 -23.62304 1.000 11.53043 ? 653 HOH A O   1 
HETATM 3244 O  O   . HOH L 5 .   ? -7.38408  25.43496 3.87892   1.000 25.12161 ? 654 HOH A O   1 
HETATM 3245 O  O   . HOH L 5 .   ? -28.95716 6.84617  -0.09396  1.000 27.55741 ? 655 HOH A O   1 
HETATM 3246 O  O   . HOH L 5 .   ? -14.45701 25.53070 14.53490  1.000 31.40274 ? 656 HOH A O   1 
HETATM 3247 O  O   . HOH L 5 .   ? -12.34293 27.14942 14.03937  1.000 35.22108 ? 657 HOH A O   1 
HETATM 3248 O  O   . HOH L 5 .   ? -0.03235  18.72422 -1.94512  1.000 23.00116 ? 658 HOH A O   1 
HETATM 3249 O  O   . HOH L 5 .   ? -37.78035 35.65006 -1.39374  1.000 25.95164 ? 659 HOH A O   1 
HETATM 3250 O  O   . HOH L 5 .   ? -2.66953  32.47902 -24.84072 1.000 23.50658 ? 660 HOH A O   1 
HETATM 3251 O  O   . HOH L 5 .   ? -12.18002 33.55359 -9.37118  1.000 11.73794 ? 661 HOH A O   1 
HETATM 3252 O  O   . HOH L 5 .   ? -35.23799 36.86775 5.84434   1.000 28.41001 ? 662 HOH A O   1 
HETATM 3253 O  O   . HOH L 5 .   ? -40.82248 24.10462 -19.40693 1.000 20.22053 ? 663 HOH A O   1 
HETATM 3254 O  O   . HOH L 5 .   ? -18.70726 44.73593 -2.88891  1.000 31.57033 ? 664 HOH A O   1 
HETATM 3255 O  O   . HOH L 5 .   ? -23.17202 14.69408 -16.72947 1.000 27.41391 ? 665 HOH A O   1 
HETATM 3256 O  O   . HOH L 5 .   ? -4.65728  55.34269 -13.59615 1.000 30.20591 ? 666 HOH A O   1 
HETATM 3257 O  O   . HOH L 5 .   ? -11.13633 36.91581 -29.23868 1.000 10.76328 ? 667 HOH A O   1 
HETATM 3258 O  O   . HOH L 5 .   ? -29.92094 25.32455 -23.42001 1.000 7.37669  ? 668 HOH A O   1 
HETATM 3259 O  O   . HOH L 5 .   ? -35.75326 17.47338 16.13952  1.000 30.51148 ? 669 HOH A O   1 
HETATM 3260 O  O   . HOH L 5 .   ? -32.43264 26.83175 0.03742   1.000 9.47430  ? 670 HOH A O   1 
HETATM 3261 O  O   . HOH L 5 .   ? -2.81852  31.29231 -1.92733  1.000 38.36130 ? 671 HOH A O   1 
HETATM 3262 O  O   . HOH L 5 .   ? -2.36258  16.96199 0.80655   1.000 28.82815 ? 672 HOH A O   1 
HETATM 3263 O  O   . HOH L 5 .   ? -14.32940 51.53023 -0.61308  1.000 37.28444 ? 673 HOH A O   1 
HETATM 3264 O  O   . HOH L 5 .   ? -15.29398 28.81776 11.96300  1.000 17.47881 ? 674 HOH A O   1 
HETATM 3265 O  O   . HOH L 5 .   ? -18.64060 22.11584 2.60108   1.000 14.32538 ? 675 HOH A O   1 
HETATM 3266 O  O   . HOH L 5 .   ? -30.45043 40.87753 -29.13500 1.000 41.62816 ? 676 HOH A O   1 
HETATM 3267 O  O   . HOH L 5 .   ? -40.08535 31.92078 12.80845  1.000 17.66939 ? 677 HOH A O   1 
HETATM 3268 O  O   . HOH L 5 .   ? -41.32991 28.76076 15.09798  1.000 22.79939 ? 678 HOH A O   1 
HETATM 3269 O  O   . HOH L 5 .   ? -12.63946 16.90316 9.11039   1.000 21.30134 ? 679 HOH A O   1 
HETATM 3270 O  O   . HOH L 5 .   ? -16.55271 7.09049  -15.00368 1.000 29.30605 ? 680 HOH A O   1 
HETATM 3271 O  O   . HOH L 5 .   ? -30.22631 41.39575 -25.14913 1.000 33.74140 ? 681 HOH A O   1 
HETATM 3272 O  O   . HOH L 5 .   ? 0.30934   39.98932 -17.84929 1.000 26.46895 ? 682 HOH A O   1 
HETATM 3273 O  O   . HOH L 5 .   ? -38.36296 31.55064 17.06365  1.000 20.88400 ? 683 HOH A O   1 
HETATM 3274 O  O   . HOH L 5 .   ? -41.32316 17.64002 8.34354   1.000 33.64818 ? 684 HOH A O   1 
HETATM 3275 O  O   . HOH L 5 .   ? 4.72124   42.79808 -6.58415  1.000 34.95535 ? 685 HOH A O   1 
HETATM 3276 O  O   . HOH L 5 .   ? -16.18695 48.03770 -17.57803 1.000 23.01781 ? 686 HOH A O   1 
HETATM 3277 O  O   . HOH L 5 .   ? -21.12408 42.16205 -12.84487 1.000 14.27768 ? 687 HOH A O   1 
HETATM 3278 O  O   . HOH L 5 .   ? -37.38762 21.40143 20.76837  1.000 33.36192 ? 688 HOH A O   1 
HETATM 3279 O  O   . HOH L 5 .   ? -19.56569 38.36608 -35.19170 1.000 24.33267 ? 689 HOH A O   1 
HETATM 3280 O  O   . HOH L 5 .   ? -21.60798 35.74924 -11.22846 1.000 10.20435 ? 690 HOH A O   1 
HETATM 3281 O  O   . HOH L 5 .   ? -43.91983 20.10158 5.35730   1.000 12.63372 ? 691 HOH A O   1 
HETATM 3282 O  O   . HOH L 5 .   ? -19.80823 45.80216 -6.48996  1.000 30.77212 ? 692 HOH A O   1 
HETATM 3283 O  O   . HOH L 5 .   ? -3.43850  20.24959 -18.23377 1.000 20.40603 ? 693 HOH A O   1 
HETATM 3284 O  O   . HOH L 5 .   ? -6.21321  48.61275 -22.25443 1.000 30.12854 ? 694 HOH A O   1 
HETATM 3285 O  O   . HOH L 5 .   ? 1.56705   15.17501 -3.99242  1.000 40.07703 ? 695 HOH A O   1 
HETATM 3286 O  O   . HOH L 5 .   ? -10.60038 55.27900 -12.45219 1.000 28.48785 ? 696 HOH A O   1 
HETATM 3287 O  O   . HOH L 5 .   ? -30.82582 16.91217 -19.55047 1.000 30.88951 ? 697 HOH A O   1 
HETATM 3288 O  O   . HOH L 5 .   ? -27.02814 20.42114 25.55471  1.000 37.98942 ? 698 HOH A O   1 
HETATM 3289 O  O   . HOH L 5 .   ? -37.55315 31.92199 -26.32995 1.000 41.92799 ? 699 HOH A O   1 
HETATM 3290 O  O   . HOH L 5 .   ? -20.96190 22.65777 18.25056  1.000 27.09725 ? 700 HOH A O   1 
HETATM 3291 O  O   . HOH L 5 .   ? -4.85561  12.37017 -5.09431  1.000 19.90513 ? 701 HOH A O   1 
HETATM 3292 O  O   . HOH L 5 .   ? -23.97700 37.76924 -18.93866 1.000 12.96804 ? 702 HOH A O   1 
HETATM 3293 O  O   . HOH L 5 .   ? -14.38500 52.25696 -11.24538 1.000 30.19172 ? 703 HOH A O   1 
HETATM 3294 O  O   . HOH L 5 .   ? -35.91939 18.53388 -15.56779 1.000 21.88913 ? 704 HOH A O   1 
HETATM 3295 O  O   . HOH L 5 .   ? -9.30099  37.41578 -7.55181  1.000 14.76577 ? 705 HOH A O   1 
HETATM 3296 O  O   . HOH L 5 .   ? -20.89068 27.19023 -6.99787  1.000 15.69821 ? 706 HOH A O   1 
HETATM 3297 O  O   . HOH L 5 .   ? 3.97074   44.80683 -0.03369  1.000 30.92684 ? 707 HOH A O   1 
HETATM 3298 O  O   . HOH L 5 .   ? -12.36608 27.73701 -5.03598  1.000 13.97008 ? 708 HOH A O   1 
HETATM 3299 O  O   . HOH L 5 .   ? -13.42914 52.99139 -21.15025 1.000 30.62070 ? 709 HOH A O   1 
HETATM 3300 O  O   . HOH L 5 .   ? -2.46738  37.18042 -4.81567  1.000 28.91134 ? 710 HOH A O   1 
HETATM 3301 O  O   . HOH L 5 .   ? -30.98452 26.60653 5.11221   1.000 24.27985 ? 711 HOH A O   1 
HETATM 3302 O  O   . HOH L 5 .   ? 0.02694   53.65363 -10.33564 1.000 31.03783 ? 712 HOH A O   1 
HETATM 3303 O  O   . HOH L 5 .   ? -26.31676 20.46532 -27.42637 1.000 12.79462 ? 713 HOH A O   1 
HETATM 3304 O  O   . HOH L 5 .   ? -23.26801 24.71760 -10.33253 1.000 15.38104 ? 714 HOH A O   1 
HETATM 3305 O  O   . HOH L 5 .   ? -31.57223 16.29509 -15.46852 1.000 21.60939 ? 715 HOH A O   1 
HETATM 3306 O  O   . HOH L 5 .   ? -28.60637 15.39558 20.57082  1.000 37.34458 ? 716 HOH A O   1 
HETATM 3307 O  O   . HOH L 5 .   ? -9.13454  35.09312 -22.43537 1.000 9.80505  ? 717 HOH A O   1 
HETATM 3308 O  O   . HOH L 5 .   ? -24.41318 11.89140 -13.06337 1.000 42.44699 ? 718 HOH A O   1 
HETATM 3309 O  O   . HOH L 5 .   ? -11.45224 34.90262 -6.98000  1.000 19.17380 ? 719 HOH A O   1 
HETATM 3310 O  O   . HOH L 5 .   ? -2.82218  35.63832 -2.01169  1.000 39.49573 ? 720 HOH A O   1 
HETATM 3311 O  O   . HOH L 5 .   ? -12.33191 10.07564 8.12728   1.000 27.14356 ? 721 HOH A O   1 
HETATM 3312 O  O   . HOH L 5 .   ? -17.20264 31.06346 -19.78547 1.000 8.68338  ? 722 HOH A O   1 
HETATM 3313 O  O   . HOH L 5 .   ? -12.91060 24.53313 -5.26355  1.000 11.26258 ? 723 HOH A O   1 
HETATM 3314 O  O   . HOH L 5 .   ? -20.86452 21.30125 -32.47152 1.000 14.37107 ? 724 HOH A O   1 
HETATM 3315 O  O   . HOH L 5 .   ? -41.54452 13.19581 -1.76556  1.000 19.23437 ? 725 HOH A O   1 
HETATM 3316 O  O   . HOH L 5 .   ? -20.19306 34.00139 2.35651   1.000 34.91415 ? 726 HOH A O   1 
HETATM 3317 O  O   . HOH L 5 .   ? -3.79550  43.77996 -2.36757  1.000 24.08338 ? 727 HOH A O   1 
HETATM 3318 O  O   . HOH L 5 .   ? -12.01184 55.53831 -1.36461  1.000 28.27599 ? 728 HOH A O   1 
HETATM 3319 O  O   . HOH L 5 .   ? 2.47779   37.13707 -19.16453 1.000 33.00557 ? 729 HOH A O   1 
HETATM 3320 O  O   . HOH L 5 .   ? -16.36597 37.95467 -1.75406  1.000 22.05120 ? 730 HOH A O   1 
HETATM 3321 O  O   . HOH L 5 .   ? -33.42319 41.59583 -24.88730 1.000 32.37527 ? 731 HOH A O   1 
HETATM 3322 O  O   . HOH L 5 .   ? 4.54255   49.35760 -9.10431  1.000 32.70998 ? 732 HOH A O   1 
HETATM 3323 O  O   . HOH L 5 .   ? -36.63519 26.33748 -26.83190 1.000 35.07946 ? 733 HOH A O   1 
HETATM 3324 O  O   . HOH L 5 .   ? -24.62282 24.46299 -35.51012 1.000 31.59462 ? 734 HOH A O   1 
HETATM 3325 O  O   . HOH L 5 .   ? -1.23084  18.14820 -13.84369 1.000 32.77701 ? 735 HOH A O   1 
HETATM 3326 O  O   . HOH L 5 .   ? -44.61386 33.09177 -12.47122 1.000 31.21146 ? 736 HOH A O   1 
HETATM 3327 O  O   . HOH L 5 .   ? -20.23304 30.67164 -2.40521  1.000 29.48043 ? 737 HOH A O   1 
HETATM 3328 O  O   . HOH L 5 .   ? -15.31276 48.63917 -19.71135 1.000 25.59938 ? 738 HOH A O   1 
HETATM 3329 O  O   . HOH L 5 .   ? -24.86609 35.23859 -14.42950 1.000 15.23771 ? 739 HOH A O   1 
HETATM 3330 O  O   . HOH L 5 .   ? -9.69581  9.39467  6.99546   1.000 34.18929 ? 740 HOH A O   1 
HETATM 3331 O  O   . HOH L 5 .   ? -4.67050  41.58046 -7.79632  1.000 13.52389 ? 741 HOH A O   1 
HETATM 3332 O  O   . HOH L 5 .   ? -33.43885 38.85493 -11.67389 1.000 27.98134 ? 742 HOH A O   1 
HETATM 3333 O  O   . HOH L 5 .   ? -9.75269  21.05615 -23.74243 1.000 13.32028 ? 743 HOH A O   1 
HETATM 3334 O  O   . HOH L 5 .   ? -27.12457 25.32004 -31.31970 1.000 20.78704 ? 744 HOH A O   1 
HETATM 3335 O  O   . HOH L 5 .   ? -33.17119 14.25476 8.36977   1.000 29.84386 ? 745 HOH A O   1 
HETATM 3336 O  O   . HOH L 5 .   ? -25.10432 37.27461 -3.43939  1.000 42.62568 ? 746 HOH A O   1 
HETATM 3337 O  O   . HOH L 5 .   ? -27.15102 20.11000 22.89569  1.000 31.16733 ? 747 HOH A O   1 
HETATM 3338 O  O   . HOH L 5 .   ? -14.01389 20.82442 13.85917  1.000 25.41127 ? 748 HOH A O   1 
HETATM 3339 O  O   . HOH L 5 .   ? -23.72457 11.73592 -9.36871  1.000 32.87945 ? 749 HOH A O   1 
HETATM 3340 O  O   . HOH L 5 .   ? -20.36485 30.14885 -5.84696  1.000 23.55924 ? 750 HOH A O   1 
HETATM 3341 O  O   . HOH L 5 .   ? -20.71971 17.90669 16.83024  1.000 24.08809 ? 751 HOH A O   1 
HETATM 3342 O  O   . HOH L 5 .   ? -9.99343  3.85513  -3.78563  1.000 39.92432 ? 752 HOH A O   1 
HETATM 3343 O  O   . HOH L 5 .   ? -1.13997  31.44020 -17.88536 1.000 15.10346 ? 753 HOH A O   1 
HETATM 3344 O  O   . HOH L 5 .   ? -42.17337 11.15468 7.86646   1.000 36.89443 ? 754 HOH A O   1 
HETATM 3345 O  O   . HOH L 5 .   ? -35.39363 36.25619 9.68073   1.000 24.15367 ? 755 HOH A O   1 
HETATM 3346 O  O   . HOH L 5 .   ? -28.12084 28.67875 -32.00215 1.000 36.01853 ? 756 HOH A O   1 
HETATM 3347 O  O   . HOH L 5 .   ? -9.16688  27.54413 -31.50047 1.000 27.32992 ? 757 HOH A O   1 
HETATM 3348 O  O   . HOH L 5 .   ? -42.80350 13.30847 6.98743   1.000 32.80072 ? 758 HOH A O   1 
HETATM 3349 O  O   . HOH L 5 .   ? -2.11990  51.53960 -13.76513 1.000 40.30166 ? 759 HOH A O   1 
HETATM 3350 O  O   . HOH L 5 .   ? -33.14005 37.20916 7.96661   1.000 23.39338 ? 760 HOH A O   1 
HETATM 3351 O  O   . HOH L 5 .   ? -9.56995  33.21522 -6.01832  1.000 25.36598 ? 761 HOH A O   1 
HETATM 3352 O  O   . HOH L 5 .   ? -6.10350  39.71701 -25.86683 1.000 32.71065 ? 762 HOH A O   1 
HETATM 3353 O  O   . HOH L 5 .   ? -24.26799 26.83731 -36.13126 1.000 35.60347 ? 763 HOH A O   1 
HETATM 3354 O  O   . HOH L 5 .   ? -11.30803 39.67318 -34.72772 1.000 17.04240 ? 764 HOH A O   1 
HETATM 3355 O  O   . HOH L 5 .   ? -1.20663  41.33235 -13.73377 1.000 37.83243 ? 765 HOH A O   1 
HETATM 3356 O  O   . HOH L 5 .   ? -36.73801 27.31362 22.46188  1.000 39.31963 ? 766 HOH A O   1 
HETATM 3357 O  O   . HOH L 5 .   ? -22.07210 33.25753 19.03905  1.000 37.69179 ? 767 HOH A O   1 
HETATM 3358 O  O   . HOH L 5 .   ? -17.57753 11.05155 -19.24071 1.000 15.79963 ? 768 HOH A O   1 
HETATM 3359 O  O   . HOH L 5 .   ? -7.93700  21.40373 -32.81081 1.000 19.51213 ? 769 HOH A O   1 
HETATM 3360 O  O   . HOH L 5 .   ? -12.56987 43.43100 2.71502   1.000 60.64342 ? 770 HOH A O   1 
HETATM 3361 O  O   . HOH L 5 .   ? -42.04960 37.59504 10.71177  1.000 37.66630 ? 771 HOH A O   1 
HETATM 3362 O  O   . HOH L 5 .   ? -3.71835  46.30806 -24.27211 1.000 28.64290 ? 772 HOH A O   1 
HETATM 3363 O  O   . HOH L 5 .   ? -0.97698  21.59262 -16.65032 1.000 32.27360 ? 773 HOH A O   1 
HETATM 3364 O  O   . HOH L 5 .   ? -27.03060 22.05516 -32.87933 1.000 28.26604 ? 774 HOH A O   1 
HETATM 3365 O  O   . HOH L 5 .   ? 0.88728   22.13444 -12.11441 1.000 21.23067 ? 775 HOH A O   1 
HETATM 3366 O  O   . HOH L 5 .   ? -5.24796  25.22786 11.07784  1.000 44.11509 ? 776 HOH A O   1 
HETATM 3367 O  O   . HOH L 5 .   ? -41.16276 25.16398 -13.26033 1.000 22.51376 ? 777 HOH A O   1 
HETATM 3368 O  O   . HOH L 5 .   ? -13.55832 40.35231 -24.62564 1.000 18.53195 ? 778 HOH A O   1 
HETATM 3369 O  O   . HOH L 5 .   ? -32.36954 24.81760 -26.64500 1.000 27.58404 ? 779 HOH A O   1 
HETATM 3370 O  O   . HOH L 5 .   ? -1.31698  27.98768 -13.53186 1.000 25.18265 ? 780 HOH A O   1 
HETATM 3371 O  O   . HOH L 5 .   ? -23.72239 28.76857 20.69557  1.000 38.64642 ? 781 HOH A O   1 
HETATM 3372 O  O   . HOH L 5 .   ? -2.10814  22.94444 -0.02102  1.000 30.62436 ? 782 HOH A O   1 
HETATM 3373 O  O   . HOH L 5 .   ? -11.00509 21.35581 -8.13247  1.000 25.01242 ? 783 HOH A O   1 
HETATM 3374 O  O   . HOH L 5 .   ? -14.56019 32.14410 5.65261   1.000 34.02136 ? 784 HOH A O   1 
HETATM 3375 O  O   . HOH L 5 .   ? -41.94774 21.95551 -10.38853 1.000 34.94799 ? 785 HOH A O   1 
HETATM 3376 O  O   . HOH L 5 .   ? -20.82825 42.07020 -8.42339  1.000 25.42480 ? 786 HOH A O   1 
HETATM 3377 O  O   . HOH L 5 .   ? -18.71040 29.20448 19.82610  1.000 34.01046 ? 787 HOH A O   1 
HETATM 3378 O  O   . HOH L 5 .   ? -40.44469 33.60508 10.84320  1.000 17.08871 ? 788 HOH A O   1 
HETATM 3379 O  O   . HOH L 5 .   ? -20.60625 27.65299 -35.27474 1.000 28.29702 ? 789 HOH A O   1 
HETATM 3380 O  O   . HOH L 5 .   ? -16.72220 49.27654 -13.97233 1.000 28.34057 ? 790 HOH A O   1 
HETATM 3381 O  O   . HOH L 5 .   ? -24.18161 36.76097 -6.70658  1.000 25.02759 ? 791 HOH A O   1 
HETATM 3382 O  O   . HOH L 5 .   ? -18.28625 31.40786 9.45694   1.000 20.50245 ? 792 HOH A O   1 
HETATM 3383 O  O   . HOH L 5 .   ? 0.57734   49.33121 -10.41145 1.000 21.15409 ? 793 HOH A O   1 
HETATM 3384 O  O   . HOH L 5 .   ? -42.95695 31.41176 -12.01718 1.000 24.10336 ? 794 HOH A O   1 
HETATM 3385 O  O   . HOH L 5 .   ? -3.18852  37.20158 -12.22927 1.000 18.53259 ? 795 HOH A O   1 
HETATM 3386 O  O   . HOH L 5 .   ? -1.86554  16.50615 -16.35124 1.000 26.56406 ? 796 HOH A O   1 
HETATM 3387 O  O   . HOH L 5 .   ? -9.63942  53.61360 1.44011   1.000 30.67167 ? 797 HOH A O   1 
HETATM 3388 O  O   . HOH L 5 .   ? -2.34689  26.93256 -1.95996  1.000 37.20342 ? 798 HOH A O   1 
HETATM 3389 O  O   . HOH L 5 .   ? -41.56524 24.30418 -11.08949 1.000 33.18565 ? 799 HOH A O   1 
HETATM 3390 O  O   . HOH L 5 .   ? -18.01701 15.77557 -28.56005 1.000 27.00231 ? 800 HOH A O   1 
HETATM 3391 O  O   . HOH L 5 .   ? -11.92041 38.12096 -7.00989  1.000 11.93150 ? 801 HOH A O   1 
HETATM 3392 O  O   . HOH L 5 .   ? -1.00692  44.05275 -23.15596 1.000 21.66007 ? 802 HOH A O   1 
HETATM 3393 O  O   . HOH L 5 .   ? -44.02701 26.20637 11.40002  1.000 26.17796 ? 803 HOH A O   1 
HETATM 3394 O  O   . HOH L 5 .   ? -28.23977 21.18532 -25.06300 1.000 12.91559 ? 804 HOH A O   1 
HETATM 3395 O  O   . HOH L 5 .   ? -22.88472 43.87357 -13.91484 1.000 28.21222 ? 805 HOH A O   1 
HETATM 3396 O  O   . HOH L 5 .   ? -35.35334 36.78813 12.43290  1.000 30.50758 ? 806 HOH A O   1 
HETATM 3397 O  O   . HOH L 5 .   ? 1.48234   17.60395 -5.71405  1.000 34.06909 ? 807 HOH A O   1 
HETATM 3398 O  O   . HOH L 5 .   ? -37.28946 28.71656 -23.77573 1.000 15.51637 ? 808 HOH A O   1 
HETATM 3399 O  O   . HOH L 5 .   ? -7.49713  17.13652 -24.11052 1.000 29.82659 ? 809 HOH A O   1 
HETATM 3400 O  O   . HOH L 5 .   ? -18.44877 11.28602 -15.48047 1.000 17.46115 ? 810 HOH A O   1 
HETATM 3401 O  O   . HOH L 5 .   ? -13.23258 29.85006 7.74272   1.000 21.33633 ? 811 HOH A O   1 
HETATM 3402 O  O   . HOH L 5 .   ? -22.86002 34.52177 -5.84625  1.000 33.22200 ? 812 HOH A O   1 
HETATM 3403 O  O   . HOH L 5 .   ? -28.32258 24.56889 -29.65777 1.000 25.07988 ? 813 HOH A O   1 
HETATM 3404 O  O   . HOH L 5 .   ? -22.34688 41.91500 -10.93359 1.000 30.88713 ? 814 HOH A O   1 
HETATM 3405 O  O   . HOH L 5 .   ? -24.77172 18.79592 19.44138  1.000 30.90274 ? 815 HOH A O   1 
HETATM 3406 O  O   . HOH L 5 .   ? -49.30831 34.22424 5.44237   1.000 32.93758 ? 816 HOH A O   1 
HETATM 3407 O  O   . HOH L 5 .   ? -20.00166 12.91736 -17.47079 1.000 13.74108 ? 817 HOH A O   1 
HETATM 3408 O  O   . HOH L 5 .   ? -14.75425 7.89063  -9.10459  1.000 33.17370 ? 818 HOH A O   1 
HETATM 3409 O  O   . HOH L 5 .   ? -34.48515 14.40587 -11.21642 1.000 27.99110 ? 819 HOH A O   1 
HETATM 3410 O  O   . HOH L 5 .   ? -20.29458 55.20463 -4.29167  1.000 47.65622 ? 820 HOH A O   1 
HETATM 3411 O  O   . HOH L 5 .   ? 1.20238   35.41407 -24.80417 1.000 28.14155 ? 821 HOH A O   1 
HETATM 3412 O  O   . HOH L 5 .   ? -25.34434 21.06980 20.73862  1.000 34.69631 ? 822 HOH A O   1 
HETATM 3413 O  O   . HOH L 5 .   ? -28.44878 17.47436 -20.79365 1.000 28.67797 ? 823 HOH A O   1 
HETATM 3414 O  O   . HOH L 5 .   ? -35.57146 18.41139 -20.08030 1.000 32.58133 ? 824 HOH A O   1 
HETATM 3415 O  O   . HOH L 5 .   ? -29.06934 28.24559 -29.98780 1.000 25.96170 ? 825 HOH A O   1 
HETATM 3416 O  O   . HOH L 5 .   ? -13.67755 32.47586 -3.06886  1.000 19.18230 ? 826 HOH A O   1 
HETATM 3417 O  O   . HOH L 5 .   ? -21.513   44.602   -31.166   1.000 18.86902 ? 827 HOH A O   1 
HETATM 3418 O  O   . HOH L 5 .   ? -26.99053 18.60833 -24.67291 1.000 29.83431 ? 828 HOH A O   1 
HETATM 3419 O  O   . HOH L 5 .   ? -10.46009 39.23486 -28.51353 1.000 20.50707 ? 829 HOH A O   1 
HETATM 3420 O  O   . HOH L 5 .   ? -24.62303 18.71166 -26.16904 1.000 20.51995 ? 830 HOH A O   1 
HETATM 3421 O  O   . HOH L 5 .   ? -25.17662 43.18893 -15.72358 1.000 38.37799 ? 831 HOH A O   1 
HETATM 3422 O  O   . HOH L 5 .   ? -34.66764 14.58984 -13.40711 1.000 27.35010 ? 832 HOH A O   1 
HETATM 3423 O  O   . HOH L 5 .   ? -41.45499 37.30705 1.67450   1.000 37.03768 ? 833 HOH A O   1 
HETATM 3424 O  O   . HOH L 5 .   ? -29.98800 36.61936 -29.91856 1.000 37.23929 ? 834 HOH A O   1 
HETATM 3425 O  O   . HOH L 5 .   ? -41.53480 33.65849 -16.59074 1.000 39.65667 ? 835 HOH A O   1 
HETATM 3426 O  O   . HOH L 5 .   ? -40.94680 22.23962 -21.16196 1.000 31.86929 ? 836 HOH A O   1 
HETATM 3427 O  O   . HOH L 5 .   ? 1.04859   30.72994 -19.65901 1.000 30.45554 ? 837 HOH A O   1 
HETATM 3428 O  O   . HOH L 5 .   ? -5.94321  9.93411  -4.80301  1.000 30.80391 ? 838 HOH A O   1 
HETATM 3429 O  O   . HOH L 5 .   ? -26.39829 33.73170 10.62020  1.000 33.94685 ? 839 HOH A O   1 
HETATM 3430 O  O   . HOH L 5 .   ? -34.91098 18.48946 23.64397  1.000 37.59716 ? 840 HOH A O   1 
HETATM 3431 O  O   . HOH L 5 .   ? -34.79431 12.68013 7.27910   1.000 30.81184 ? 841 HOH A O   1 
HETATM 3432 O  O   . HOH L 5 .   ? -21.90196 31.08613 -3.94971  1.000 24.79909 ? 842 HOH A O   1 
HETATM 3433 O  O   . HOH L 5 .   ? -12.96457 15.35346 -31.92134 1.000 32.99444 ? 843 HOH A O   1 
HETATM 3434 O  O   . HOH L 5 .   ? -2.28616  35.25473 -11.12835 1.000 33.02931 ? 844 HOH A O   1 
HETATM 3435 O  O   . HOH L 5 .   ? -3.85170  17.69177 -18.04166 1.000 21.51260 ? 845 HOH A O   1 
HETATM 3436 O  O   . HOH L 5 .   ? -21.53480 8.86304  -27.71844 1.000 32.35831 ? 846 HOH A O   1 
HETATM 3437 O  O   . HOH L 5 .   ? -37.06100 31.17043 -24.03446 1.000 30.03669 ? 847 HOH A O   1 
HETATM 3438 O  O   . HOH L 5 .   ? -33.86232 7.98016  3.17840   1.000 27.06887 ? 848 HOH A O   1 
HETATM 3439 O  O   . HOH L 5 .   ? -2.70931  39.79075 -10.98677 1.000 28.44228 ? 849 HOH A O   1 
HETATM 3440 O  O   . HOH L 5 .   ? -38.42059 20.34634 18.47029  1.000 27.82106 ? 850 HOH A O   1 
HETATM 3441 O  O   . HOH L 5 .   ? -19.97179 8.41041  -8.72442  1.000 34.33608 ? 851 HOH A O   1 
HETATM 3442 O  O   . HOH L 5 .   ? -11.45323 29.90761 9.16333   1.000 30.17190 ? 852 HOH A O   1 
HETATM 3443 O  O   . HOH L 5 .   ? -22.37998 32.89336 10.10754  1.000 32.42957 ? 853 HOH A O   1 
HETATM 3444 O  O   . HOH L 5 .   ? -3.13971  42.04618 -12.20001 1.000 27.26026 ? 854 HOH A O   1 
HETATM 3445 O  O   . HOH L 5 .   ? -21.19472 13.33038 -19.85937 1.000 31.01196 ? 855 HOH A O   1 
HETATM 3446 O  O   . HOH L 5 .   ? -3.482    18.317   6.495     1.000 33.99996 ? 856 HOH A O   1 
HETATM 3447 O  O   . HOH L 5 .   ? -2.97169  12.11165 -7.19500  1.000 27.55839 ? 857 HOH A O   1 
HETATM 3448 O  O   . HOH L 5 .   ? -15.01181 32.94926 -1.19065  1.000 31.16180 ? 858 HOH A O   1 
HETATM 3449 O  O   . HOH L 5 .   ? -28.48731 22.45485 -27.67666 1.000 12.37558 ? 859 HOH A O   1 
HETATM 3450 O  O   . HOH L 5 .   ? -42.60226 29.66418 -14.13614 1.000 27.39366 ? 860 HOH A O   1 
HETATM 3451 O  O   . HOH L 5 .   ? 2.82195   22.25626 -9.93209  1.000 31.28653 ? 861 HOH A O   1 
HETATM 3452 O  O   . HOH L 5 .   ? 0.76782   19.40842 -13.83064 1.000 38.54857 ? 862 HOH A O   1 
HETATM 3453 O  O   . HOH L 5 .   ? -0.90424  32.07818 -1.18340  1.000 38.57437 ? 863 HOH A O   1 
HETATM 3454 O  O   . HOH L 5 .   ? -13.16782 41.71102 -1.65611  1.000 28.39831 ? 864 HOH A O   1 
HETATM 3455 O  O   . HOH L 5 .   ? -0.91221  42.54482 -18.58410 1.000 25.78416 ? 865 HOH A O   1 
HETATM 3456 O  O   . HOH L 5 .   ? -22.25040 40.93206 -6.29159  1.000 35.67908 ? 866 HOH A O   1 
HETATM 3457 O  O   . HOH L 5 .   ? -18.684   8.305    -27.472   1.000 20.80135 ? 867 HOH A O   1 
HETATM 3458 O  O   . HOH L 5 .   ? -20.91678 44.63058 -8.60392  1.000 32.25940 ? 868 HOH A O   1 
HETATM 3459 O  O   . HOH L 5 .   ? -38.05662 17.77249 17.67281  1.000 39.48102 ? 869 HOH A O   1 
HETATM 3460 O  O   . HOH L 5 .   ? 0.63702   40.19022 -15.00744 1.000 39.49498 ? 870 HOH A O   1 
HETATM 3461 O  O   . HOH L 5 .   ? -6.44252  9.96265  -15.12536 1.000 32.75961 ? 871 HOH A O   1 
HETATM 3462 O  O   . HOH L 5 .   ? -15.82524 30.97819 10.69030  1.000 29.13519 ? 872 HOH A O   1 
HETATM 3463 O  O   . HOH L 5 .   ? -1.85598  13.63669 -8.55797  1.000 36.53687 ? 873 HOH A O   1 
HETATM 3464 O  O   . HOH L 5 .   ? -24.67075 42.82767 -10.59296 1.000 33.53755 ? 874 HOH A O   1 
HETATM 3465 O  O   . HOH L 5 .   ? -21.20664 10.24532 -12.98216 1.000 35.56596 ? 875 HOH A O   1 
HETATM 3466 O  O   . HOH L 5 .   ? -18.36902 8.52806  -16.43486 1.000 26.84528 ? 876 HOH A O   1 
HETATM 3467 O  O   . HOH L 5 .   ? -27.74276 42.76278 -19.38411 1.000 34.77698 ? 877 HOH A O   1 
HETATM 3468 O  O   . HOH L 5 .   ? -20.60438 20.23196 18.62152  1.000 35.98868 ? 878 HOH A O   1 
HETATM 3469 O  O   . HOH L 5 .   ? -40.47351 23.64937 13.57239  1.000 27.68093 ? 879 HOH A O   1 
HETATM 3470 O  O   . HOH L 5 .   ? 0.00000   20.84353 0.00000   0.50  29.02155 ? 880 HOH A O   1 
HETATM 3471 O  O   . HOH L 5 .   ? -44.923   23.667   -10.881   1.000 38.46364 ? 881 HOH A O   1 
HETATM 3472 O  O   . HOH L 5 .   ? -34.18359 9.70475  7.08159   1.000 28.75861 ? 882 HOH A O   1 
HETATM 3473 O  O   . HOH L 5 .   ? -12.72077 19.12879 13.19473  1.000 32.25251 ? 883 HOH A O   1 
HETATM 3474 O  O   . HOH L 5 .   ? -23.53698 14.21862 -19.87238 1.000 34.85976 ? 884 HOH A O   1 
HETATM 3475 O  O   . HOH L 5 .   ? -33.00089 16.20931 -19.90186 1.000 37.36670 ? 885 HOH A O   1 
HETATM 3476 O  O   . HOH L 5 .   ? -35.56518 36.10158 -5.07140  1.000 28.85452 ? 886 HOH A O   1 
HETATM 3477 O  O   . HOH L 5 .   ? -3.19260  14.40082 0.54705   1.000 32.32236 ? 887 HOH A O   1 
HETATM 3478 O  O   . HOH L 5 .   ? -8.788    14.403   -24.607   1.000 23.72999 ? 888 HOH A O   1 
HETATM 3479 O  O   . HOH L 5 .   ? -38.55750 31.01184 -20.06197 1.000 25.52612 ? 889 HOH A O   1 
HETATM 3480 O  O   . HOH L 5 .   ? -32.42297 9.75710  9.16255   1.000 34.45819 ? 890 HOH A O   1 
HETATM 3481 O  O   . HOH L 5 .   ? -20.56507 31.72384 10.15328  1.000 20.82918 ? 891 HOH A O   1 
HETATM 3482 O  O   . HOH L 5 .   ? -16.186   45.372   -24.513   1.000 32.76954 ? 892 HOH A O   1 
HETATM 3483 O  O   . HOH L 5 .   ? -2.38300  49.49271 -17.93101 1.000 29.66156 ? 893 HOH A O   1 
HETATM 3484 O  O   . HOH L 5 .   ? -38.44086 27.35251 -25.68676 1.000 32.84356 ? 894 HOH A O   1 
HETATM 3485 O  O   . HOH L 5 .   ? -41.66398 23.26020 -15.01360 1.000 30.72683 ? 895 HOH A O   1 
HETATM 3486 O  O   . HOH L 5 .   ? -26.86465 15.87968 -20.83374 1.000 35.56447 ? 896 HOH A O   1 
HETATM 3487 O  O   . HOH L 5 .   ? -21.92755 35.39398 -2.66595  1.000 40.73641 ? 897 HOH A O   1 
HETATM 3488 O  O   . HOH L 5 .   ? -38.94106 28.64424 -21.35782 1.000 29.08133 ? 898 HOH A O   1 
HETATM 3489 O  O   . HOH L 5 .   ? -1.29241  38.55747 -10.04174 1.000 39.85742 ? 899 HOH A O   1 
HETATM 3490 O  O   . HOH L 5 .   ? -0.28130  13.21976 -5.32981  1.000 35.58109 ? 900 HOH A O   1 
HETATM 3491 O  O   . HOH L 5 .   ? -1.96710  20.27534 -20.68257 1.000 31.24172 ? 901 HOH A O   1 
HETATM 3492 O  O   . HOH L 5 .   ? -15.29306 5.06201  -14.55134 1.000 31.72611 ? 902 HOH A O   1 
HETATM 3493 O  O   . HOH L 5 .   ? -20.39349 46.29368 -10.69182 1.000 35.99549 ? 903 HOH A O   1 
HETATM 3494 O  O   . HOH L 5 .   ? 1.36571   16.35334 -10.77153 1.000 36.11456 ? 904 HOH A O   1 
HETATM 3495 O  O   . HOH L 5 .   ? -22.546   41.926   -31.753   1.000 26.14040 ? 905 HOH A O   1 
HETATM 3496 O  O   . HOH L 5 .   ? -14.95205 39.52244 -0.27364  1.000 24.77958 ? 906 HOH A O   1 
HETATM 3497 O  O   . HOH L 5 .   ? -37.00772 19.06505 22.36356  1.000 40.01425 ? 907 HOH A O   1 
HETATM 3498 O  O   . HOH L 5 .   ? -12.87562 6.86884  -10.80022 1.000 35.83182 ? 908 HOH A O   1 
HETATM 3499 O  O   . HOH L 5 .   ? -41.10330 27.58221 -21.58597 1.000 34.28869 ? 909 HOH A O   1 
HETATM 3500 O  O   . HOH L 5 .   ? -31.90443 12.42683 9.82363   1.000 34.18505 ? 910 HOH A O   1 
HETATM 3501 O  O   . HOH L 5 .   ? -37.83441 36.54688 12.92168  1.000 22.75843 ? 911 HOH A O   1 
HETATM 3502 O  O   . HOH L 5 .   ? -42.47012 23.44280 -17.31424 1.000 31.00692 ? 912 HOH A O   1 
HETATM 3503 O  O   . HOH L 5 .   ? -11.02678 25.91228 -33.27619 1.000 20.80320 ? 913 HOH A O   1 
HETATM 3504 O  O   . HOH L 5 .   ? -39.32704 35.99939 10.63397  1.000 19.66335 ? 914 HOH A O   1 
HETATM 3505 O  O   . HOH L 5 .   ? -1.65052  19.64001 -15.89579 1.000 33.73468 ? 915 HOH A O   1 
HETATM 3506 O  O   . HOH L 5 .   ? -38.84519 33.77427 -16.99615 1.000 22.12738 ? 916 HOH A O   1 
HETATM 3507 O  O   . HOH L 5 .   ? -11.26443 41.56799 0.94823   1.000 37.05956 ? 917 HOH A O   1 
HETATM 3508 O  O   . HOH L 5 .   ? -42.36307 25.47781 -21.26615 1.000 36.15898 ? 918 HOH A O   1 
HETATM 3509 O  O   . HOH L 5 .   ? -35.19371 38.52342 3.74826   1.000 29.56928 ? 919 HOH A O   1 
HETATM 3510 O  O   . HOH L 5 .   ? -5.71036  51.45599 -15.46256 1.000 22.68485 ? 920 HOH A O   1 
HETATM 3511 O  O   . HOH L 5 .   ? -23.04220 38.69513 -4.81368  1.000 38.73752 ? 921 HOH A O   1 
HETATM 3512 O  O   . HOH L 5 .   ? -38.88565 34.75165 14.48278  1.000 29.15803 ? 922 HOH A O   1 
HETATM 3513 O  O   . HOH L 5 .   ? 1.88046   51.28304 -8.97466  1.000 39.57424 ? 923 HOH A O   1 
HETATM 3514 O  O   . HOH L 5 .   ? -17.94446 45.80015 -19.03526 1.000 28.69185 ? 924 HOH A O   1 
HETATM 3515 O  O   . HOH L 5 .   ? -42.39942 10.88984 2.26304   1.000 36.13554 ? 925 HOH A O   1 
HETATM 3516 O  O   . HOH L 5 .   ? -33.99237 38.44522 13.73408  1.000 31.63029 ? 926 HOH A O   1 
HETATM 3517 O  O   . HOH L 5 .   ? -21.15726 11.28949 -15.91593 1.000 32.75013 ? 927 HOH A O   1 
HETATM 3518 O  O   . HOH L 5 .   ? -20.18925 34.67130 -0.82304  1.000 38.72704 ? 928 HOH A O   1 
HETATM 3519 O  O   . HOH L 5 .   ? 0.19230   34.39379 -26.78507 1.000 33.69695 ? 929 HOH A O   1 
# 
