data_9FK3
# 
_entry.id   9FK3 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FK3         pdb_00009fk3 10.2210/pdb9fk3/pdb 
WWPDB D_1292139006 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FK3 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          Shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Chmelnik, O.' 2 ? 
'Dessau, M.'   3 ? 
'Shoham, Y.'   4 ? 
'Shoham, G.'   5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;The structure of glycosynthase XT6 (E265G mutant), the extracellular xylanase of G.proteiniphilus T-6 in complex with xylobiose-F and xylotetraose-F molecules
;
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Chmelnik, O.' 2 ? 
primary 'Dessau, M.'   3 ? 
primary 'Shoham, Y.'   4 ? 
primary 'Shoham, G.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Endo-1,4-beta-xylanase                                                                                  
43800.582 1   3.2.1.8 ? ? ? 
2 branched    syn 'beta-D-xylopyranose-(1-4)-1-fluoro-D-xylopyranose'                                                     284.236 
1   ?       ? ? ? 
3 branched    syn 'beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-1-fluoro-D-xylopyranose' 548.465 
1   ?       ? ? ? 
4 non-polymer syn 'ZINC ION'                                                                                              65.409 6 
?       ? ? ? 
5 non-polymer syn 'CHLORIDE ION'                                                                                          35.453 2 
?       ? ? ? 
6 water       nat water                                                                                                   18.015 
401 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Xylanase,1,4-beta-D-xylan xylanohydrolase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'ZINC ION'     ZN  
5 'CHLORIDE ION' CL  
6 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   ASN n 
1 3   ALA n 
1 4   ASP n 
1 5   SER n 
1 6   TYR n 
1 7   ALA n 
1 8   LYS n 
1 9   LYS n 
1 10  PRO n 
1 11  HIS n 
1 12  ILE n 
1 13  SER n 
1 14  ALA n 
1 15  LEU n 
1 16  ASN n 
1 17  ALA n 
1 18  PRO n 
1 19  GLN n 
1 20  LEU n 
1 21  ASP n 
1 22  GLN n 
1 23  ARG n 
1 24  TYR n 
1 25  LYS n 
1 26  ASN n 
1 27  GLU n 
1 28  PHE n 
1 29  THR n 
1 30  ILE n 
1 31  GLY n 
1 32  ALA n 
1 33  ALA n 
1 34  VAL n 
1 35  GLU n 
1 36  PRO n 
1 37  TYR n 
1 38  GLN n 
1 39  LEU n 
1 40  GLN n 
1 41  ASN n 
1 42  GLU n 
1 43  LYS n 
1 44  ASP n 
1 45  VAL n 
1 46  GLN n 
1 47  MET n 
1 48  LEU n 
1 49  LYS n 
1 50  ARG n 
1 51  HIS n 
1 52  PHE n 
1 53  ASN n 
1 54  SER n 
1 55  ILE n 
1 56  VAL n 
1 57  ALA n 
1 58  GLU n 
1 59  ASN n 
1 60  VAL n 
1 61  MET n 
1 62  LYS n 
1 63  PRO n 
1 64  ILE n 
1 65  SER n 
1 66  ILE n 
1 67  GLN n 
1 68  PRO n 
1 69  GLU n 
1 70  GLU n 
1 71  GLY n 
1 72  LYS n 
1 73  PHE n 
1 74  ASN n 
1 75  PHE n 
1 76  GLU n 
1 77  GLN n 
1 78  ALA n 
1 79  ASP n 
1 80  ARG n 
1 81  ILE n 
1 82  VAL n 
1 83  LYS n 
1 84  PHE n 
1 85  ALA n 
1 86  LYS n 
1 87  ALA n 
1 88  ASN n 
1 89  GLY n 
1 90  MET n 
1 91  ASP n 
1 92  ILE n 
1 93  ARG n 
1 94  PHE n 
1 95  HIS n 
1 96  THR n 
1 97  LEU n 
1 98  VAL n 
1 99  TRP n 
1 100 HIS n 
1 101 SER n 
1 102 GLN n 
1 103 VAL n 
1 104 PRO n 
1 105 GLN n 
1 106 TRP n 
1 107 PHE n 
1 108 PHE n 
1 109 LEU n 
1 110 ASP n 
1 111 LYS n 
1 112 GLU n 
1 113 GLY n 
1 114 LYS n 
1 115 PRO n 
1 116 MET n 
1 117 VAL n 
1 118 ASN n 
1 119 GLU n 
1 120 THR n 
1 121 ASP n 
1 122 PRO n 
1 123 VAL n 
1 124 LYS n 
1 125 ARG n 
1 126 GLU n 
1 127 GLN n 
1 128 ASN n 
1 129 LYS n 
1 130 GLN n 
1 131 LEU n 
1 132 LEU n 
1 133 LEU n 
1 134 LYS n 
1 135 ARG n 
1 136 LEU n 
1 137 GLU n 
1 138 THR n 
1 139 HIS n 
1 140 ILE n 
1 141 LYS n 
1 142 THR n 
1 143 ILE n 
1 144 VAL n 
1 145 GLU n 
1 146 ARG n 
1 147 TYR n 
1 148 LYS n 
1 149 ASP n 
1 150 ASP n 
1 151 ILE n 
1 152 LYS n 
1 153 TYR n 
1 154 TRP n 
1 155 ASP n 
1 156 VAL n 
1 157 VAL n 
1 158 ASN n 
1 159 GLU n 
1 160 VAL n 
1 161 VAL n 
1 162 GLY n 
1 163 ASP n 
1 164 ASP n 
1 165 GLY n 
1 166 LYS n 
1 167 LEU n 
1 168 ARG n 
1 169 ASN n 
1 170 SER n 
1 171 PRO n 
1 172 TRP n 
1 173 TYR n 
1 174 GLN n 
1 175 ILE n 
1 176 ALA n 
1 177 GLY n 
1 178 ILE n 
1 179 ASP n 
1 180 TYR n 
1 181 ILE n 
1 182 LYS n 
1 183 VAL n 
1 184 ALA n 
1 185 PHE n 
1 186 GLN n 
1 187 ALA n 
1 188 ALA n 
1 189 ARG n 
1 190 LYS n 
1 191 TYR n 
1 192 GLY n 
1 193 GLY n 
1 194 ASP n 
1 195 ASN n 
1 196 ILE n 
1 197 LYS n 
1 198 LEU n 
1 199 TYR n 
1 200 MET n 
1 201 ASN n 
1 202 ASP n 
1 203 TYR n 
1 204 ASN n 
1 205 THR n 
1 206 GLU n 
1 207 VAL n 
1 208 GLU n 
1 209 PRO n 
1 210 LYS n 
1 211 ARG n 
1 212 THR n 
1 213 ALA n 
1 214 LEU n 
1 215 TYR n 
1 216 ASN n 
1 217 LEU n 
1 218 VAL n 
1 219 LYS n 
1 220 GLN n 
1 221 LEU n 
1 222 LYS n 
1 223 GLU n 
1 224 GLU n 
1 225 GLY n 
1 226 VAL n 
1 227 PRO n 
1 228 ILE n 
1 229 ASP n 
1 230 GLY n 
1 231 ILE n 
1 232 GLY n 
1 233 HIS n 
1 234 GLN n 
1 235 SER n 
1 236 HIS n 
1 237 ILE n 
1 238 GLN n 
1 239 ILE n 
1 240 GLY n 
1 241 TRP n 
1 242 PRO n 
1 243 SER n 
1 244 GLU n 
1 245 ALA n 
1 246 GLU n 
1 247 ILE n 
1 248 GLU n 
1 249 LYS n 
1 250 THR n 
1 251 ILE n 
1 252 ASN n 
1 253 MET n 
1 254 PHE n 
1 255 ALA n 
1 256 ALA n 
1 257 LEU n 
1 258 GLY n 
1 259 LEU n 
1 260 ASP n 
1 261 ASN n 
1 262 GLN n 
1 263 ILE n 
1 264 THR n 
1 265 GLY n 
1 266 LEU n 
1 267 ASP n 
1 268 VAL n 
1 269 SER n 
1 270 MET n 
1 271 TYR n 
1 272 GLY n 
1 273 TRP n 
1 274 PRO n 
1 275 PRO n 
1 276 ARG n 
1 277 ALA n 
1 278 TYR n 
1 279 PRO n 
1 280 THR n 
1 281 TYR n 
1 282 ASP n 
1 283 ALA n 
1 284 ILE n 
1 285 PRO n 
1 286 LYS n 
1 287 GLN n 
1 288 LYS n 
1 289 PHE n 
1 290 LEU n 
1 291 ASP n 
1 292 GLN n 
1 293 ALA n 
1 294 ALA n 
1 295 ARG n 
1 296 TYR n 
1 297 ASP n 
1 298 ARG n 
1 299 LEU n 
1 300 PHE n 
1 301 LYS n 
1 302 LEU n 
1 303 TYR n 
1 304 GLU n 
1 305 LYS n 
1 306 LEU n 
1 307 SER n 
1 308 ASP n 
1 309 LYS n 
1 310 ILE n 
1 311 SER n 
1 312 ASN n 
1 313 VAL n 
1 314 THR n 
1 315 PHE n 
1 316 TRP n 
1 317 GLY n 
1 318 ILE n 
1 319 ALA n 
1 320 ASP n 
1 321 ASN n 
1 322 HIS n 
1 323 THR n 
1 324 TRP n 
1 325 LEU n 
1 326 ASP n 
1 327 SER n 
1 328 ARG n 
1 329 ALA n 
1 330 ASP n 
1 331 VAL n 
1 332 TYR n 
1 333 TYR n 
1 334 ASP n 
1 335 ALA n 
1 336 ASN n 
1 337 GLY n 
1 338 ASN n 
1 339 VAL n 
1 340 VAL n 
1 341 VAL n 
1 342 ASP n 
1 343 PRO n 
1 344 ASN n 
1 345 ALA n 
1 346 PRO n 
1 347 TYR n 
1 348 ALA n 
1 349 LYS n 
1 350 VAL n 
1 351 GLU n 
1 352 LYS n 
1 353 GLY n 
1 354 LYS n 
1 355 GLY n 
1 356 LYS n 
1 357 ASP n 
1 358 ALA n 
1 359 PRO n 
1 360 PHE n 
1 361 VAL n 
1 362 PHE n 
1 363 GLY n 
1 364 PRO n 
1 365 ASP n 
1 366 TYR n 
1 367 LYS n 
1 368 VAL n 
1 369 LYS n 
1 370 PRO n 
1 371 ALA n 
1 372 TYR n 
1 373 TRP n 
1 374 ALA n 
1 375 ILE n 
1 376 ILE n 
1 377 ASP n 
1 378 HIS n 
1 379 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   379 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus proteiniphilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     860353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_branch.entity_id 
_pdbx_entity_branch.type 
2 oligosaccharide 
3 oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 '[][&lt;C5O3F1&gt;]{[(1+1)][b-D-Xylp]{}}'                                       LINUCS PDB-CARE ? 
2 3 '[][&lt;C5O3F1&gt;]{[(1+1)][b-D-Xylp]{[(4+1)][b-D-Xylp]{[(4+1)][b-D-Xylp]{}}}}' LINUCS PDB-CARE ? 
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 2 2 XYP C1 O1 1 A1ID6 O4 HO4 sing ? 
2 3 2 XYP C1 O1 1 A1ID6 O4 HO4 sing ? 
3 3 3 XYP C1 O1 2 XYP   O4 HO4 sing ? 
4 3 4 XYP C1 O1 3 XYP   O4 HO4 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ID6 D-saccharide                 . 1-fluoro-D-xylopyranose ?                                 'C5 H9 F O4'     152.121 
ALA   'L-peptide linking'          y ALANINE                 ?                                 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking'          y ARGININE                ?                                 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking'          y ASPARAGINE              ?                                 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking'          y 'ASPARTIC ACID'         ?                                 'C4 H7 N O4'     133.103 
CL    non-polymer                  . 'CHLORIDE ION'          ?                                 'Cl -1'          35.453  
GLN   'L-peptide linking'          y GLUTAMINE               ?                                 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking'          y 'GLUTAMIC ACID'         ?                                 'C5 H9 N O4'     147.129 
GLY   'peptide linking'            y GLYCINE                 ?                                 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking'          y HISTIDINE               ?                                 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer                  . WATER                   ?                                 'H2 O'           18.015  
ILE   'L-peptide linking'          y ISOLEUCINE              ?                                 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking'          y LEUCINE                 ?                                 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking'          y LYSINE                  ?                                 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking'          y METHIONINE              ?                                 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking'          y PHENYLALANINE           ?                                 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking'          y PROLINE                 ?                                 'C5 H9 N O2'     115.130 
SER   'L-peptide linking'          y SERINE                  ?                                 'C3 H7 N O3'     105.093 
THR   'L-peptide linking'          y THREONINE               ?                                 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking'          y TRYPTOPHAN              ?                                 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking'          y TYROSINE                ?                                 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking'          y VALINE                  ?                                 'C5 H11 N O2'    117.146 
XYP   'D-saccharide, beta linking' . beta-D-xylopyranose     'beta-D-xylose; D-xylose; xylose' 'C5 H10 O5'      150.130 
ZN    non-polymer                  . 'ZINC ION'              ?                                 'Zn 2'           65.409  
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
XYP 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DXylpb           
XYP 'COMMON NAME'                         GMML     1.0 b-D-xylopyranose 
XYP 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Xylp         
XYP 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Xyl              
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   ALA 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   5   SER SER A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  PRO 10  10  10  PRO PRO A . n 
A 1 11  HIS 11  11  11  HIS HIS A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLN 22  22  22  GLN GLN A . n 
A 1 23  ARG 23  23  23  ARG ARG A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  PHE 28  28  28  PHE PHE A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  PRO 36  36  36  PRO PRO A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  GLN 40  40  40  GLN GLN A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  ASP 44  44  44  ASP ASP A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  MET 61  61  61  MET MET A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  SER 65  65  65  SER SER A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  LYS 72  72  72  LYS LYS A . n 
A 1 73  PHE 73  73  73  PHE PHE A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  PHE 75  75  75  PHE PHE A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  GLN 77  77  77  GLN GLN A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  ASN 88  88  88  ASN ASN A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ARG 93  93  93  ARG ARG A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  HIS 95  95  95  HIS HIS A . n 
A 1 96  THR 96  96  96  THR THR A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  TRP 99  99  99  TRP TRP A . n 
A 1 100 HIS 100 100 100 HIS HIS A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 GLN 105 105 105 GLN GLN A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 GLU 112 112 112 GLU GLU A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 PRO 115 115 115 PRO PRO A . n 
A 1 116 MET 116 116 116 MET MET A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLU 126 126 126 GLU GLU A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 ASN 128 128 128 ASN ASN A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 ARG 135 135 135 ARG ARG A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 THR 138 138 138 THR THR A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 GLU 145 145 145 GLU GLU A . n 
A 1 146 ARG 146 146 146 ARG ARG A . n 
A 1 147 TYR 147 147 147 TYR TYR A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 ASP 149 149 149 ASP ASP A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 ILE 151 151 151 ILE ILE A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 TRP 154 154 154 TRP TRP A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ASN 158 158 158 ASN ASN A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 LYS 166 166 166 LYS LYS A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 ASN 169 169 169 ASN ASN A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 ILE 175 175 175 ILE ILE A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 TYR 180 180 180 TYR TYR A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 GLN 186 186 186 GLN GLN A . n 
A 1 187 ALA 187 187 187 ALA ALA A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 ASN 195 195 195 ASN ASN A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 LEU 198 198 198 LEU LEU A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 MET 200 200 200 MET MET A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 GLU 206 206 206 GLU GLU A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 GLU 208 208 208 GLU GLU A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 TYR 215 215 215 TYR TYR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 LYS 219 219 219 LYS LYS A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 TRP 241 241 241 TRP TRP A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 GLU 246 246 246 GLU GLU A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 ILE 251 251 251 ILE ILE A . n 
A 1 252 ASN 252 252 252 ASN ASN A . n 
A 1 253 MET 253 253 253 MET MET A . n 
A 1 254 PHE 254 254 254 PHE PHE A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 ASN 261 261 261 ASN ASN A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 THR 264 264 264 THR THR A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 SER 269 269 269 SER SER A . n 
A 1 270 MET 270 270 270 MET MET A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 TRP 273 273 273 TRP TRP A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 PRO 275 275 275 PRO PRO A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 TYR 278 278 278 TYR TYR A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 ILE 284 284 284 ILE ILE A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 GLN 287 287 287 GLN GLN A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ASP 291 291 291 ASP ASP A . n 
A 1 292 GLN 292 292 292 GLN GLN A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 LEU 302 302 302 LEU LEU A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 SER 307 307 307 SER SER A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ILE 310 310 310 ILE ILE A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 THR 314 314 314 THR THR A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 TRP 316 316 316 TRP TRP A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ILE 318 318 318 ILE ILE A . n 
A 1 319 ALA 319 319 319 ALA ALA A . n 
A 1 320 ASP 320 320 320 ASP ASP A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 HIS 322 322 322 HIS HIS A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 TRP 324 324 324 TRP TRP A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 ARG 328 328 328 ARG ARG A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ASP 330 330 330 ASP ASP A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
A 1 332 TYR 332 332 332 TYR TYR A . n 
A 1 333 TYR 333 333 333 TYR TYR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 ASN 344 344 344 ASN ASN A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 PRO 346 346 346 PRO PRO A . n 
A 1 347 TYR 347 347 347 TYR TYR A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 GLU 351 351 351 GLU GLU A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 LYS 354 354 354 LYS LYS A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LYS 356 356 356 LYS LYS A . n 
A 1 357 ASP 357 357 357 ASP ASP A . n 
A 1 358 ALA 358 358 358 ALA ALA A . n 
A 1 359 PRO 359 359 359 PRO PRO A . n 
A 1 360 PHE 360 360 360 PHE PHE A . n 
A 1 361 VAL 361 361 361 VAL VAL A . n 
A 1 362 PHE 362 362 362 PHE PHE A . n 
A 1 363 GLY 363 363 363 GLY GLY A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 ASP 365 365 365 ASP ASP A . n 
A 1 366 TYR 366 366 366 TYR TYR A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 PRO 370 370 370 PRO PRO A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 TYR 372 372 372 TYR TYR A . n 
A 1 373 TRP 373 373 373 TRP TRP A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 ASP 377 377 377 ASP ASP A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 LYS 379 379 379 LYS LYS A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 A1ID6 1 D A1ID6 1 A XBA 401 n 
B 2 XYP   2 D XYP   2 A XBA 401 n 
C 3 A1ID6 1 E A1ID6 1 A XTA 501 n 
C 3 XYP   2 E XYP   2 A XTA 501 n 
C 3 XYP   3 E XYP   3 A XTA 501 n 
C 3 XYP   4 E XYP   4 A XTA 501 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 XYP   ? ? XYP   ? ? 'SUBJECT OF INVESTIGATION' ? 
2 A1ID6 ? ? A1ID6 ? ? 'SUBJECT OF INVESTIGATION' ? 
3 XYP   ? ? XYP   ? ? 'SUBJECT OF INVESTIGATION' ? 
4 A1ID6 ? ? A1ID6 ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 ZN  1   401 8   ZN  ZN  A . 
E 4 ZN  1   402 9   ZN  ZN  A . 
F 4 ZN  1   403 10  ZN  ZN  A . 
G 4 ZN  1   404 11  ZN  ZN  A . 
H 4 ZN  1   405 12  ZN  ZN  A . 
I 4 ZN  1   406 13  ZN  ZN  A . 
J 5 CL  1   407 3   CL  CL  A . 
K 5 CL  1   408 4   CL  CL  A . 
L 6 HOH 1   501 371 HOH HOH A . 
L 6 HOH 2   502 279 HOH HOH A . 
L 6 HOH 3   503 31  HOH HOH A . 
L 6 HOH 4   504 254 HOH HOH A . 
L 6 HOH 5   505 209 HOH HOH A . 
L 6 HOH 6   506 54  HOH HOH A . 
L 6 HOH 7   507 136 HOH HOH A . 
L 6 HOH 8   508 28  HOH HOH A . 
L 6 HOH 9   509 334 HOH HOH A . 
L 6 HOH 10  510 244 HOH HOH A . 
L 6 HOH 11  511 267 HOH HOH A . 
L 6 HOH 12  512 20  HOH HOH A . 
L 6 HOH 13  513 400 HOH HOH A . 
L 6 HOH 14  514 312 HOH HOH A . 
L 6 HOH 15  515 355 HOH HOH A . 
L 6 HOH 16  516 402 HOH HOH A . 
L 6 HOH 17  517 166 HOH HOH A . 
L 6 HOH 18  518 331 HOH HOH A . 
L 6 HOH 19  519 173 HOH HOH A . 
L 6 HOH 20  520 271 HOH HOH A . 
L 6 HOH 21  521 419 HOH HOH A . 
L 6 HOH 22  522 18  HOH HOH A . 
L 6 HOH 23  523 110 HOH HOH A . 
L 6 HOH 24  524 205 HOH HOH A . 
L 6 HOH 25  525 303 HOH HOH A . 
L 6 HOH 26  526 367 HOH HOH A . 
L 6 HOH 27  527 88  HOH HOH A . 
L 6 HOH 28  528 321 HOH HOH A . 
L 6 HOH 29  529 174 HOH HOH A . 
L 6 HOH 30  530 3   HOH HOH A . 
L 6 HOH 31  531 115 HOH HOH A . 
L 6 HOH 32  532 422 HOH HOH A . 
L 6 HOH 33  533 266 HOH HOH A . 
L 6 HOH 34  534 332 HOH HOH A . 
L 6 HOH 35  535 44  HOH HOH A . 
L 6 HOH 36  536 13  HOH HOH A . 
L 6 HOH 37  537 214 HOH HOH A . 
L 6 HOH 38  538 368 HOH HOH A . 
L 6 HOH 39  539 100 HOH HOH A . 
L 6 HOH 40  540 6   HOH HOH A . 
L 6 HOH 41  541 376 HOH HOH A . 
L 6 HOH 42  542 387 HOH HOH A . 
L 6 HOH 43  543 108 HOH HOH A . 
L 6 HOH 44  544 152 HOH HOH A . 
L 6 HOH 45  545 342 HOH HOH A . 
L 6 HOH 46  546 188 HOH HOH A . 
L 6 HOH 47  547 140 HOH HOH A . 
L 6 HOH 48  548 94  HOH HOH A . 
L 6 HOH 49  549 150 HOH HOH A . 
L 6 HOH 50  550 36  HOH HOH A . 
L 6 HOH 51  551 245 HOH HOH A . 
L 6 HOH 52  552 218 HOH HOH A . 
L 6 HOH 53  553 339 HOH HOH A . 
L 6 HOH 54  554 377 HOH HOH A . 
L 6 HOH 55  555 219 HOH HOH A . 
L 6 HOH 56  556 177 HOH HOH A . 
L 6 HOH 57  557 406 HOH HOH A . 
L 6 HOH 58  558 81  HOH HOH A . 
L 6 HOH 59  559 107 HOH HOH A . 
L 6 HOH 60  560 389 HOH HOH A . 
L 6 HOH 61  561 35  HOH HOH A . 
L 6 HOH 62  562 22  HOH HOH A . 
L 6 HOH 63  563 393 HOH HOH A . 
L 6 HOH 64  564 12  HOH HOH A . 
L 6 HOH 65  565 7   HOH HOH A . 
L 6 HOH 66  566 33  HOH HOH A . 
L 6 HOH 67  567 352 HOH HOH A . 
L 6 HOH 68  568 80  HOH HOH A . 
L 6 HOH 69  569 70  HOH HOH A . 
L 6 HOH 70  570 76  HOH HOH A . 
L 6 HOH 71  571 95  HOH HOH A . 
L 6 HOH 72  572 296 HOH HOH A . 
L 6 HOH 73  573 129 HOH HOH A . 
L 6 HOH 74  574 34  HOH HOH A . 
L 6 HOH 75  575 9   HOH HOH A . 
L 6 HOH 76  576 195 HOH HOH A . 
L 6 HOH 77  577 50  HOH HOH A . 
L 6 HOH 78  578 83  HOH HOH A . 
L 6 HOH 79  579 10  HOH HOH A . 
L 6 HOH 80  580 40  HOH HOH A . 
L 6 HOH 81  581 207 HOH HOH A . 
L 6 HOH 82  582 11  HOH HOH A . 
L 6 HOH 83  583 111 HOH HOH A . 
L 6 HOH 84  584 281 HOH HOH A . 
L 6 HOH 85  585 4   HOH HOH A . 
L 6 HOH 86  586 282 HOH HOH A . 
L 6 HOH 87  587 120 HOH HOH A . 
L 6 HOH 88  588 38  HOH HOH A . 
L 6 HOH 89  589 378 HOH HOH A . 
L 6 HOH 90  590 116 HOH HOH A . 
L 6 HOH 91  591 144 HOH HOH A . 
L 6 HOH 92  592 37  HOH HOH A . 
L 6 HOH 93  593 175 HOH HOH A . 
L 6 HOH 94  594 328 HOH HOH A . 
L 6 HOH 95  595 117 HOH HOH A . 
L 6 HOH 96  596 53  HOH HOH A . 
L 6 HOH 97  597 68  HOH HOH A . 
L 6 HOH 98  598 149 HOH HOH A . 
L 6 HOH 99  599 60  HOH HOH A . 
L 6 HOH 100 600 143 HOH HOH A . 
L 6 HOH 101 601 114 HOH HOH A . 
L 6 HOH 102 602 29  HOH HOH A . 
L 6 HOH 103 603 30  HOH HOH A . 
L 6 HOH 104 604 62  HOH HOH A . 
L 6 HOH 105 605 113 HOH HOH A . 
L 6 HOH 106 606 5   HOH HOH A . 
L 6 HOH 107 607 301 HOH HOH A . 
L 6 HOH 108 608 142 HOH HOH A . 
L 6 HOH 109 609 304 HOH HOH A . 
L 6 HOH 110 610 362 HOH HOH A . 
L 6 HOH 111 611 14  HOH HOH A . 
L 6 HOH 112 612 215 HOH HOH A . 
L 6 HOH 113 613 326 HOH HOH A . 
L 6 HOH 114 614 247 HOH HOH A . 
L 6 HOH 115 615 168 HOH HOH A . 
L 6 HOH 116 616 43  HOH HOH A . 
L 6 HOH 117 617 226 HOH HOH A . 
L 6 HOH 118 618 127 HOH HOH A . 
L 6 HOH 119 619 366 HOH HOH A . 
L 6 HOH 120 620 103 HOH HOH A . 
L 6 HOH 121 621 158 HOH HOH A . 
L 6 HOH 122 622 198 HOH HOH A . 
L 6 HOH 123 623 73  HOH HOH A . 
L 6 HOH 124 624 180 HOH HOH A . 
L 6 HOH 125 625 82  HOH HOH A . 
L 6 HOH 126 626 384 HOH HOH A . 
L 6 HOH 127 627 145 HOH HOH A . 
L 6 HOH 128 628 230 HOH HOH A . 
L 6 HOH 129 629 329 HOH HOH A . 
L 6 HOH 130 630 26  HOH HOH A . 
L 6 HOH 131 631 315 HOH HOH A . 
L 6 HOH 132 632 55  HOH HOH A . 
L 6 HOH 133 633 19  HOH HOH A . 
L 6 HOH 134 634 17  HOH HOH A . 
L 6 HOH 135 635 164 HOH HOH A . 
L 6 HOH 136 636 32  HOH HOH A . 
L 6 HOH 137 637 153 HOH HOH A . 
L 6 HOH 138 638 131 HOH HOH A . 
L 6 HOH 139 639 15  HOH HOH A . 
L 6 HOH 140 640 305 HOH HOH A . 
L 6 HOH 141 641 320 HOH HOH A . 
L 6 HOH 142 642 112 HOH HOH A . 
L 6 HOH 143 643 23  HOH HOH A . 
L 6 HOH 144 644 106 HOH HOH A . 
L 6 HOH 145 645 90  HOH HOH A . 
L 6 HOH 146 646 256 HOH HOH A . 
L 6 HOH 147 647 58  HOH HOH A . 
L 6 HOH 148 648 101 HOH HOH A . 
L 6 HOH 149 649 327 HOH HOH A . 
L 6 HOH 150 650 259 HOH HOH A . 
L 6 HOH 151 651 102 HOH HOH A . 
L 6 HOH 152 652 79  HOH HOH A . 
L 6 HOH 153 653 217 HOH HOH A . 
L 6 HOH 154 654 423 HOH HOH A . 
L 6 HOH 155 655 124 HOH HOH A . 
L 6 HOH 156 656 2   HOH HOH A . 
L 6 HOH 157 657 284 HOH HOH A . 
L 6 HOH 158 658 64  HOH HOH A . 
L 6 HOH 159 659 42  HOH HOH A . 
L 6 HOH 160 660 59  HOH HOH A . 
L 6 HOH 161 661 91  HOH HOH A . 
L 6 HOH 162 662 360 HOH HOH A . 
L 6 HOH 163 663 269 HOH HOH A . 
L 6 HOH 164 664 51  HOH HOH A . 
L 6 HOH 165 665 121 HOH HOH A . 
L 6 HOH 166 666 407 HOH HOH A . 
L 6 HOH 167 667 72  HOH HOH A . 
L 6 HOH 168 668 85  HOH HOH A . 
L 6 HOH 169 669 8   HOH HOH A . 
L 6 HOH 170 670 24  HOH HOH A . 
L 6 HOH 171 671 27  HOH HOH A . 
L 6 HOH 172 672 16  HOH HOH A . 
L 6 HOH 173 673 239 HOH HOH A . 
L 6 HOH 174 674 396 HOH HOH A . 
L 6 HOH 175 675 61  HOH HOH A . 
L 6 HOH 176 676 104 HOH HOH A . 
L 6 HOH 177 677 343 HOH HOH A . 
L 6 HOH 178 678 216 HOH HOH A . 
L 6 HOH 179 679 330 HOH HOH A . 
L 6 HOH 180 680 21  HOH HOH A . 
L 6 HOH 181 681 170 HOH HOH A . 
L 6 HOH 182 682 189 HOH HOH A . 
L 6 HOH 183 683 67  HOH HOH A . 
L 6 HOH 184 684 133 HOH HOH A . 
L 6 HOH 185 685 128 HOH HOH A . 
L 6 HOH 186 686 414 HOH HOH A . 
L 6 HOH 187 687 184 HOH HOH A . 
L 6 HOH 188 688 258 HOH HOH A . 
L 6 HOH 189 689 137 HOH HOH A . 
L 6 HOH 190 690 162 HOH HOH A . 
L 6 HOH 191 691 52  HOH HOH A . 
L 6 HOH 192 692 1   HOH HOH A . 
L 6 HOH 193 693 74  HOH HOH A . 
L 6 HOH 194 694 45  HOH HOH A . 
L 6 HOH 195 695 123 HOH HOH A . 
L 6 HOH 196 696 179 HOH HOH A . 
L 6 HOH 197 697 211 HOH HOH A . 
L 6 HOH 198 698 167 HOH HOH A . 
L 6 HOH 199 699 163 HOH HOH A . 
L 6 HOH 200 700 86  HOH HOH A . 
L 6 HOH 201 701 49  HOH HOH A . 
L 6 HOH 202 702 379 HOH HOH A . 
L 6 HOH 203 703 75  HOH HOH A . 
L 6 HOH 204 704 47  HOH HOH A . 
L 6 HOH 205 705 397 HOH HOH A . 
L 6 HOH 206 706 232 HOH HOH A . 
L 6 HOH 207 707 46  HOH HOH A . 
L 6 HOH 208 708 148 HOH HOH A . 
L 6 HOH 209 709 221 HOH HOH A . 
L 6 HOH 210 710 89  HOH HOH A . 
L 6 HOH 211 711 220 HOH HOH A . 
L 6 HOH 212 712 318 HOH HOH A . 
L 6 HOH 213 713 425 HOH HOH A . 
L 6 HOH 214 714 273 HOH HOH A . 
L 6 HOH 215 715 235 HOH HOH A . 
L 6 HOH 216 716 286 HOH HOH A . 
L 6 HOH 217 717 146 HOH HOH A . 
L 6 HOH 218 718 78  HOH HOH A . 
L 6 HOH 219 719 183 HOH HOH A . 
L 6 HOH 220 720 161 HOH HOH A . 
L 6 HOH 221 721 427 HOH HOH A . 
L 6 HOH 222 722 270 HOH HOH A . 
L 6 HOH 223 723 165 HOH HOH A . 
L 6 HOH 224 724 41  HOH HOH A . 
L 6 HOH 225 725 411 HOH HOH A . 
L 6 HOH 226 726 160 HOH HOH A . 
L 6 HOH 227 727 69  HOH HOH A . 
L 6 HOH 228 728 169 HOH HOH A . 
L 6 HOH 229 729 154 HOH HOH A . 
L 6 HOH 230 730 364 HOH HOH A . 
L 6 HOH 231 731 415 HOH HOH A . 
L 6 HOH 232 732 398 HOH HOH A . 
L 6 HOH 233 733 138 HOH HOH A . 
L 6 HOH 234 734 93  HOH HOH A . 
L 6 HOH 235 735 208 HOH HOH A . 
L 6 HOH 236 736 347 HOH HOH A . 
L 6 HOH 237 737 426 HOH HOH A . 
L 6 HOH 238 738 359 HOH HOH A . 
L 6 HOH 239 739 190 HOH HOH A . 
L 6 HOH 240 740 298 HOH HOH A . 
L 6 HOH 241 741 98  HOH HOH A . 
L 6 HOH 242 742 134 HOH HOH A . 
L 6 HOH 243 743 56  HOH HOH A . 
L 6 HOH 244 744 385 HOH HOH A . 
L 6 HOH 245 745 65  HOH HOH A . 
L 6 HOH 246 746 358 HOH HOH A . 
L 6 HOH 247 747 335 HOH HOH A . 
L 6 HOH 248 748 317 HOH HOH A . 
L 6 HOH 249 749 363 HOH HOH A . 
L 6 HOH 250 750 280 HOH HOH A . 
L 6 HOH 251 751 289 HOH HOH A . 
L 6 HOH 252 752 39  HOH HOH A . 
L 6 HOH 253 753 156 HOH HOH A . 
L 6 HOH 254 754 255 HOH HOH A . 
L 6 HOH 255 755 57  HOH HOH A . 
L 6 HOH 256 756 288 HOH HOH A . 
L 6 HOH 257 757 231 HOH HOH A . 
L 6 HOH 258 758 92  HOH HOH A . 
L 6 HOH 259 759 293 HOH HOH A . 
L 6 HOH 260 760 361 HOH HOH A . 
L 6 HOH 261 761 202 HOH HOH A . 
L 6 HOH 262 762 71  HOH HOH A . 
L 6 HOH 263 763 374 HOH HOH A . 
L 6 HOH 264 764 118 HOH HOH A . 
L 6 HOH 265 765 238 HOH HOH A . 
L 6 HOH 266 766 290 HOH HOH A . 
L 6 HOH 267 767 257 HOH HOH A . 
L 6 HOH 268 768 229 HOH HOH A . 
L 6 HOH 269 769 119 HOH HOH A . 
L 6 HOH 270 770 201 HOH HOH A . 
L 6 HOH 271 771 262 HOH HOH A . 
L 6 HOH 272 772 424 HOH HOH A . 
L 6 HOH 273 773 417 HOH HOH A . 
L 6 HOH 274 774 274 HOH HOH A . 
L 6 HOH 275 775 405 HOH HOH A . 
L 6 HOH 276 776 66  HOH HOH A . 
L 6 HOH 277 777 383 HOH HOH A . 
L 6 HOH 278 778 48  HOH HOH A . 
L 6 HOH 279 779 369 HOH HOH A . 
L 6 HOH 280 780 87  HOH HOH A . 
L 6 HOH 281 781 147 HOH HOH A . 
L 6 HOH 282 782 77  HOH HOH A . 
L 6 HOH 283 783 252 HOH HOH A . 
L 6 HOH 284 784 283 HOH HOH A . 
L 6 HOH 285 785 237 HOH HOH A . 
L 6 HOH 286 786 157 HOH HOH A . 
L 6 HOH 287 787 399 HOH HOH A . 
L 6 HOH 288 788 261 HOH HOH A . 
L 6 HOH 289 789 84  HOH HOH A . 
L 6 HOH 290 790 250 HOH HOH A . 
L 6 HOH 291 791 380 HOH HOH A . 
L 6 HOH 292 792 25  HOH HOH A . 
L 6 HOH 293 793 268 HOH HOH A . 
L 6 HOH 294 794 324 HOH HOH A . 
L 6 HOH 295 795 159 HOH HOH A . 
L 6 HOH 296 796 246 HOH HOH A . 
L 6 HOH 297 797 224 HOH HOH A . 
L 6 HOH 298 798 206 HOH HOH A . 
L 6 HOH 299 799 391 HOH HOH A . 
L 6 HOH 300 800 182 HOH HOH A . 
L 6 HOH 301 801 395 HOH HOH A . 
L 6 HOH 302 802 316 HOH HOH A . 
L 6 HOH 303 803 401 HOH HOH A . 
L 6 HOH 304 804 421 HOH HOH A . 
L 6 HOH 305 805 97  HOH HOH A . 
L 6 HOH 306 806 63  HOH HOH A . 
L 6 HOH 307 807 109 HOH HOH A . 
L 6 HOH 308 808 187 HOH HOH A . 
L 6 HOH 309 809 241 HOH HOH A . 
L 6 HOH 310 810 370 HOH HOH A . 
L 6 HOH 311 811 234 HOH HOH A . 
L 6 HOH 312 812 130 HOH HOH A . 
L 6 HOH 313 813 285 HOH HOH A . 
L 6 HOH 314 814 346 HOH HOH A . 
L 6 HOH 315 815 333 HOH HOH A . 
L 6 HOH 316 816 409 HOH HOH A . 
L 6 HOH 317 817 178 HOH HOH A . 
L 6 HOH 318 818 176 HOH HOH A . 
L 6 HOH 319 819 300 HOH HOH A . 
L 6 HOH 320 820 412 HOH HOH A . 
L 6 HOH 321 821 96  HOH HOH A . 
L 6 HOH 322 822 272 HOH HOH A . 
L 6 HOH 323 823 325 HOH HOH A . 
L 6 HOH 324 824 155 HOH HOH A . 
L 6 HOH 325 825 151 HOH HOH A . 
L 6 HOH 326 826 228 HOH HOH A . 
L 6 HOH 327 827 193 HOH HOH A . 
L 6 HOH 328 828 341 HOH HOH A . 
L 6 HOH 329 829 200 HOH HOH A . 
L 6 HOH 330 830 192 HOH HOH A . 
L 6 HOH 331 831 191 HOH HOH A . 
L 6 HOH 332 832 292 HOH HOH A . 
L 6 HOH 333 833 373 HOH HOH A . 
L 6 HOH 334 834 275 HOH HOH A . 
L 6 HOH 335 835 122 HOH HOH A . 
L 6 HOH 336 836 291 HOH HOH A . 
L 6 HOH 337 837 186 HOH HOH A . 
L 6 HOH 338 838 125 HOH HOH A . 
L 6 HOH 339 839 382 HOH HOH A . 
L 6 HOH 340 840 299 HOH HOH A . 
L 6 HOH 341 841 242 HOH HOH A . 
L 6 HOH 342 842 381 HOH HOH A . 
L 6 HOH 343 843 240 HOH HOH A . 
L 6 HOH 344 844 302 HOH HOH A . 
L 6 HOH 345 845 338 HOH HOH A . 
L 6 HOH 346 846 340 HOH HOH A . 
L 6 HOH 347 847 225 HOH HOH A . 
L 6 HOH 348 848 390 HOH HOH A . 
L 6 HOH 349 849 345 HOH HOH A . 
L 6 HOH 350 850 394 HOH HOH A . 
L 6 HOH 351 851 388 HOH HOH A . 
L 6 HOH 352 852 126 HOH HOH A . 
L 6 HOH 353 853 196 HOH HOH A . 
L 6 HOH 354 854 386 HOH HOH A . 
L 6 HOH 355 855 351 HOH HOH A . 
L 6 HOH 356 856 260 HOH HOH A . 
L 6 HOH 357 857 297 HOH HOH A . 
L 6 HOH 358 858 306 HOH HOH A . 
L 6 HOH 359 859 265 HOH HOH A . 
L 6 HOH 360 860 139 HOH HOH A . 
L 6 HOH 361 861 227 HOH HOH A . 
L 6 HOH 362 862 428 HOH HOH A . 
L 6 HOH 363 863 204 HOH HOH A . 
L 6 HOH 364 864 243 HOH HOH A . 
L 6 HOH 365 865 319 HOH HOH A . 
L 6 HOH 366 866 185 HOH HOH A . 
L 6 HOH 367 867 413 HOH HOH A . 
L 6 HOH 368 868 311 HOH HOH A . 
L 6 HOH 369 869 194 HOH HOH A . 
L 6 HOH 370 870 105 HOH HOH A . 
L 6 HOH 371 871 248 HOH HOH A . 
L 6 HOH 372 872 418 HOH HOH A . 
L 6 HOH 373 873 141 HOH HOH A . 
L 6 HOH 374 874 222 HOH HOH A . 
L 6 HOH 375 875 251 HOH HOH A . 
L 6 HOH 376 876 181 HOH HOH A . 
L 6 HOH 377 877 404 HOH HOH A . 
L 6 HOH 378 878 392 HOH HOH A . 
L 6 HOH 379 879 356 HOH HOH A . 
L 6 HOH 380 880 416 HOH HOH A . 
L 6 HOH 381 881 223 HOH HOH A . 
L 6 HOH 382 882 344 HOH HOH A . 
L 6 HOH 383 883 212 HOH HOH A . 
L 6 HOH 384 884 253 HOH HOH A . 
L 6 HOH 385 885 135 HOH HOH A . 
L 6 HOH 386 886 323 HOH HOH A . 
L 6 HOH 387 887 309 HOH HOH A . 
L 6 HOH 388 888 295 HOH HOH A . 
L 6 HOH 389 889 403 HOH HOH A . 
L 6 HOH 390 890 276 HOH HOH A . 
L 6 HOH 391 891 313 HOH HOH A . 
L 6 HOH 392 892 203 HOH HOH A . 
L 6 HOH 393 893 372 HOH HOH A . 
L 6 HOH 394 894 263 HOH HOH A . 
L 6 HOH 395 895 308 HOH HOH A . 
L 6 HOH 396 896 294 HOH HOH A . 
L 6 HOH 397 897 197 HOH HOH A . 
L 6 HOH 398 898 213 HOH HOH A . 
L 6 HOH 399 899 410 HOH HOH A . 
L 6 HOH 400 900 210 HOH HOH A . 
L 6 HOH 401 901 408 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.252 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FK3 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     89.592 
_cell.length_a_esd                 ? 
_cell.length_b                     61.901 
_cell.length_b_esd                 ? 
_cell.length_c                     110.647 
_cell.length_c_esd                 ? 
_cell.volume                       592013.221 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FK3 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FK3 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.38 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          63.57 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.01M Zinc chloride, 17% PEG 5000, and 0.1M MES buffer at pH 6.5.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 200K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          20.79 
_reflns.entry_id                                       9FK3 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               34.10 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29862 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.12 
_reflns.pdbx_Rpim_I_all                                0.06 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.11 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.20 
_reflns_shell.d_res_low                                     2.27 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2589 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.56 
_reflns_shell.pdbx_Rpim_I_all                               0.31 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.79 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.45 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.73 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FK3 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             34.10 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29859 
_refine.ls_number_reflns_R_free                  1482 
_refine.ls_number_reflns_R_work                  28377 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.94 
_refine.ls_percent_reflns_R_free                 4.96 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1567 
_refine.ls_R_factor_R_free                       0.1996 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1545 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.6256 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2002 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        34.10 
_refine_hist.number_atoms_solvent             401 
_refine_hist.number_atoms_total               3532 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3123 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0073 ? 3210 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8481 ? 4358 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0533 ? 464  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0057 ? 556  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.5060 ? 454  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.27  . . 137 2554 99.89  . . . . 0.2036 . . . . . . . . . . . 0.2707 
'X-RAY DIFFRACTION' 2.27 2.35  . . 132 2583 100.00 . . . . 0.1877 . . . . . . . . . . . 0.2690 
'X-RAY DIFFRACTION' 2.35 2.45  . . 154 2540 100.00 . . . . 0.1830 . . . . . . . . . . . 0.2168 
'X-RAY DIFFRACTION' 2.45 2.56  . . 140 2562 99.96  . . . . 0.1705 . . . . . . . . . . . 0.2591 
'X-RAY DIFFRACTION' 2.56 2.69  . . 144 2542 100.00 . . . . 0.1722 . . . . . . . . . . . 0.2128 
'X-RAY DIFFRACTION' 2.69 2.86  . . 126 2588 99.96  . . . . 0.1675 . . . . . . . . . . . 0.2125 
'X-RAY DIFFRACTION' 2.86 3.08  . . 122 2585 100.00 . . . . 0.1668 . . . . . . . . . . . 0.2283 
'X-RAY DIFFRACTION' 3.08 3.39  . . 116 2582 99.96  . . . . 0.1580 . . . . . . . . . . . 0.2009 
'X-RAY DIFFRACTION' 3.39 3.88  . . 153 2576 99.89  . . . . 0.1396 . . . . . . . . . . . 0.1858 
'X-RAY DIFFRACTION' 3.88 4.89  . . 130 2598 99.89  . . . . 0.1214 . . . . . . . . . . . 0.1643 
'X-RAY DIFFRACTION' 4.89 34.10 . . 128 2667 99.86  . . . . 0.1360 . . . . . . . . . . . 0.1394 
# 
_struct.entry_id                     9FK3 
_struct.title                        
;The structure of glycosynthase XT6 (E265G mutant), the extracellular xylanase of G.proteiniphilus T-6 in complex with xylobiose-F and xylotetraose-F molecules
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FK3 
_struct_keywords.text            'XT6, glycosynthase, hydrolase, Geobacillus proteiniphilus T-6' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 5 ? 
K N N 5 ? 
L N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    XYN1_GEOSE 
_struct_ref.pdbx_db_accession          P40943 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITELDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_struct_ref.pdbx_align_begin           29 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FK3 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 379 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P40943 
_struct_ref_seq.db_align_beg                  29 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  407 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       379 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9FK3 
_struct_ref_seq_dif.mon_id                       GLY 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      265 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P40943 
_struct_ref_seq_dif.db_mon_id                    GLU 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          293 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            265 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2250  ? 
1 MORE         -203  ? 
1 'SSA (A^2)'  15660 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 13  ? ALA A 17  ? SER A 13  ALA A 17  5 ? 5  
HELX_P HELX_P2  AA2 GLN A 19  ? TYR A 24  ? GLN A 19  TYR A 24  1 ? 6  
HELX_P HELX_P3  AA3 GLU A 35  ? GLN A 40  ? GLU A 35  GLN A 40  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 41  ? PHE A 52  ? ASN A 41  PHE A 52  1 ? 12 
HELX_P HELX_P5  AA5 LYS A 62  ? GLN A 67  ? LYS A 62  GLN A 67  1 ? 6  
HELX_P HELX_P6  AA6 PHE A 75  ? ASN A 88  ? PHE A 75  ASN A 88  1 ? 14 
HELX_P HELX_P7  AA7 PRO A 104 ? LEU A 109 ? PRO A 104 LEU A 109 5 ? 6  
HELX_P HELX_P8  AA8 PRO A 115 ? GLU A 119 ? PRO A 115 GLU A 119 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 121 ? LYS A 148 ? ASP A 121 LYS A 148 1 ? 28 
HELX_P HELX_P10 AB1 SER A 170 ? GLY A 177 ? SER A 170 GLY A 177 1 ? 8  
HELX_P HELX_P11 AB2 ILE A 178 ? GLY A 193 ? ILE A 178 GLY A 193 1 ? 16 
HELX_P HELX_P12 AB3 PRO A 209 ? GLU A 224 ? PRO A 209 GLU A 224 1 ? 16 
HELX_P HELX_P13 AB4 SER A 243 ? LEU A 257 ? SER A 243 LEU A 257 1 ? 15 
HELX_P HELX_P14 AB5 PRO A 285 ? LEU A 306 ? PRO A 285 LEU A 306 1 ? 22 
HELX_P HELX_P15 AB6 THR A 323 ? ALA A 329 ? THR A 323 ALA A 329 5 ? 7  
HELX_P HELX_P16 AB7 LYS A 369 ? ASP A 377 ? LYS A 369 ASP A 377 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale one  ? B A1ID6 .   O4  ? ? ? 1_555 B XYP . C1 ? ? D A1ID6 1   D XYP 2   1_555 ? ? ? ? ? ? ? 1.416 ? ? 
covale2  covale one  ? C A1ID6 .   O4  ? ? ? 1_555 C XYP . C1 ? ? E A1ID6 1   E XYP 2   1_555 ? ? ? ? ? ? ? 1.426 ? ? 
covale3  covale both ? C XYP   .   O4  ? ? ? 1_555 C XYP . C1 ? ? E XYP   2   E XYP 3   1_555 ? ? ? ? ? ? ? 1.430 ? ? 
covale4  covale both ? C XYP   .   O4  ? ? ? 1_555 C XYP . C1 ? ? E XYP   3   E XYP 4   1_555 ? ? ? ? ? ? ? 1.423 ? ? 
metalc1  metalc ?    ? A HIS   11  NE2 ? ? ? 1_555 G ZN  . ZN ? ? A HIS   11  A ZN  404 1_555 ? ? ? ? ? ? ? 2.126 ? ? 
metalc2  metalc ?    ? A ASP   21  OD2 ? ? ? 1_555 I ZN  . ZN ? ? A ASP   21  A ZN  406 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
metalc3  metalc ?    ? A GLU   27  O   ? ? ? 1_555 E ZN  . ZN ? ? A GLU   27  A ZN  402 1_555 ? ? ? ? ? ? ? 2.163 ? ? 
metalc4  metalc ?    ? A GLU   27  OE2 ? ? ? 1_555 G ZN  . ZN ? ? A GLU   27  A ZN  404 4_444 ? ? ? ? ? ? ? 2.078 ? ? 
metalc5  metalc ?    ? A GLU   58  OE1 ? ? ? 1_555 D ZN  . ZN ? ? A GLU   58  A ZN  401 1_555 ? ? ? ? ? ? ? 2.110 ? ? 
metalc6  metalc ?    ? A GLU   58  OE2 ? ? ? 1_555 D ZN  . ZN ? ? A GLU   58  A ZN  401 1_555 ? ? ? ? ? ? ? 2.275 ? ? 
metalc7  metalc ?    ? A ASP   282 OD2 ? ? ? 1_555 H ZN  . ZN ? ? A ASP   282 A ZN  405 1_555 ? ? ? ? ? ? ? 2.066 ? ? 
metalc8  metalc ?    ? A ASP   297 OD1 ? ? ? 1_555 F ZN  . ZN ? ? A ASP   297 A ZN  403 1_555 ? ? ? ? ? ? ? 2.181 ? ? 
metalc9  metalc ?    ? A SER   307 O   ? ? ? 1_555 E ZN  . ZN ? ? A SER   307 A ZN  402 1_555 ? ? ? ? ? ? ? 2.213 ? ? 
metalc10 metalc ?    ? A ILE   310 O   ? ? ? 1_555 E ZN  . ZN ? ? A ILE   310 A ZN  402 1_555 ? ? ? ? ? ? ? 2.398 ? ? 
metalc11 metalc ?    ? A HIS   322 NE2 ? ? ? 1_555 D ZN  . ZN ? ? A HIS   322 A ZN  401 1_555 ? ? ? ? ? ? ? 2.028 ? ? 
metalc12 metalc ?    ? A ASP   365 OD2 ? ? ? 1_555 G ZN  . ZN ? ? A ASP   365 A ZN  404 1_555 ? ? ? ? ? ? ? 2.007 ? ? 
metalc13 metalc ?    ? A ALA   374 O   ? ? ? 1_555 F ZN  . ZN ? ? A ALA   374 A ZN  403 1_555 ? ? ? ? ? ? ? 2.292 ? ? 
metalc14 metalc ?    ? A ASP   377 OD1 ? ? ? 1_555 F ZN  . ZN ? ? A ASP   377 A ZN  403 1_555 ? ? ? ? ? ? ? 2.309 ? ? 
metalc15 metalc ?    ? A HIS   378 NE2 ? ? ? 1_555 H ZN  . ZN ? ? A HIS   378 A ZN  405 4_444 ? ? ? ? ? ? ? 2.245 ? ? 
metalc16 metalc ?    ? A LYS   379 O   ? ? ? 1_555 F ZN  . ZN ? ? A LYS   379 A ZN  403 1_555 ? ? ? ? ? ? ? 2.475 ? ? 
metalc17 metalc ?    ? D ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    401 A HOH 526 1_555 ? ? ? ? ? ? ? 1.990 ? ? 
metalc18 metalc ?    ? E ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    402 A HOH 792 1_555 ? ? ? ? ? ? ? 2.668 ? ? 
metalc19 metalc ?    ? E ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    402 A HOH 806 1_555 ? ? ? ? ? ? ? 2.618 ? ? 
metalc20 metalc ?    ? F ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    403 A HOH 510 1_555 ? ? ? ? ? ? ? 2.565 ? ? 
metalc21 metalc ?    ? F ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    403 A HOH 538 1_555 ? ? ? ? ? ? ? 2.520 ? ? 
metalc22 metalc ?    ? F ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    403 A HOH 639 1_555 ? ? ? ? ? ? ? 2.601 ? ? 
metalc23 metalc ?    ? H ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    405 A HOH 572 4_454 ? ? ? ? ? ? ? 2.563 ? ? 
metalc24 metalc ?    ? H ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    405 A HOH 779 1_555 ? ? ? ? ? ? ? 2.482 ? ? 
metalc25 metalc ?    ? I ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    406 A HOH 541 1_555 ? ? ? ? ? ? ? 2.136 ? ? 
metalc26 metalc ?    ? I ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    406 A HOH 554 1_555 ? ? ? ? ? ? ? 2.081 ? ? 
metalc27 metalc ?    ? I ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    406 A HOH 674 1_555 ? ? ? ? ? ? ? 2.151 ? ? 
metalc28 metalc ?    ? I ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    406 A HOH 763 1_555 ? ? ? ? ? ? ? 2.228 ? ? 
metalc29 metalc ?    ? I ZN    .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN    406 A HOH 833 1_555 ? ? ? ? ? ? ? 2.182 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? G ZN . ? A ZN 404 ? 1_555 OE2 ? A GLU 27  ? A GLU 27  ? 1_555 34.9  ? 
2  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? G ZN . ? A ZN 404 ? 1_555 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 119.6 ? 
3  OE2 ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? G ZN . ? A ZN 404 ? 1_555 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 98.7  ? 
4  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 541 ? 1_555 90.4  ? 
5  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 554 ? 1_555 95.2  ? 
6  O   ? L HOH .   ? A HOH 541 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 554 ? 1_555 86.3  ? 
7  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 674 ? 1_555 86.3  ? 
8  O   ? L HOH .   ? A HOH 541 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 674 ? 1_555 90.7  ? 
9  O   ? L HOH .   ? A HOH 554 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 674 ? 1_555 176.7 ? 
10 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 763 ? 1_555 93.6  ? 
11 O   ? L HOH .   ? A HOH 541 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 763 ? 1_555 175.7 ? 
12 O   ? L HOH .   ? A HOH 554 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 763 ? 1_555 91.8  ? 
13 O   ? L HOH .   ? A HOH 674 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 763 ? 1_555 91.0  ? 
14 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 833 ? 1_555 178.2 ? 
15 O   ? L HOH .   ? A HOH 541 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 833 ? 1_555 90.9  ? 
16 O   ? L HOH .   ? A HOH 554 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 833 ? 1_555 86.2  ? 
17 O   ? L HOH .   ? A HOH 674 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 833 ? 1_555 92.4  ? 
18 O   ? L HOH .   ? A HOH 763 ? 1_555 ZN ? I ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 833 ? 1_555 85.1  ? 
19 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? A SER 307 ? A SER 307 ? 1_555 107.3 ? 
20 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 94.3  ? 
21 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 84.1  ? 
22 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 792 ? 1_555 86.5  ? 
23 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 792 ? 1_555 165.1 ? 
24 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 792 ? 1_555 100.8 ? 
25 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 806 ? 1_555 162.2 ? 
26 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 806 ? 1_555 90.5  ? 
27 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 806 ? 1_555 87.1  ? 
28 O   ? L HOH .   ? A HOH 792 ? 1_555 ZN ? E ZN . ? A ZN 402 ? 1_555 O   ? L HOH .   ? A HOH 806 ? 1_555 75.8  ? 
29 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 OE2 ? A GLU 58  ? A GLU 58  ? 1_555 58.9  ? 
30 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 124.7 ? 
31 OE2 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 87.8  ? 
32 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 O   ? L HOH .   ? A HOH 526 ? 1_555 117.6 ? 
33 OE2 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 O   ? L HOH .   ? A HOH 526 ? 1_555 95.2  ? 
34 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 ZN ? D ZN . ? A ZN 401 ? 1_555 O   ? L HOH .   ? A HOH 526 ? 1_555 107.3 ? 
35 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? H ZN . ? A ZN 405 ? 1_555 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 81.9  ? 
36 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? H ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 572 ? 4_454 84.8  ? 
37 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? H ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 572 ? 4_454 151.6 ? 
38 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? H ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 779 ? 1_555 96.8  ? 
39 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? H ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 779 ? 1_555 42.4  ? 
40 O   ? L HOH .   ? A HOH 572 ? 4_454 ZN ? H ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 779 ? 1_555 165.3 ? 
41 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? A ALA 374 ? A ALA 374 ? 1_555 92.6  ? 
42 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 149.9 ? 
43 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 89.5  ? 
44 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 92.0  ? 
45 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 170.4 ? 
46 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 82.3  ? 
47 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 510 ? 1_555 75.3  ? 
48 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 510 ? 1_555 87.5  ? 
49 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 510 ? 1_555 74.8  ? 
50 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 510 ? 1_555 85.6  ? 
51 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 538 ? 1_555 140.2 ? 
52 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 538 ? 1_555 94.2  ? 
53 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 538 ? 1_555 69.5  ? 
54 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 538 ? 1_555 87.6  ? 
55 O   ? L HOH .   ? A HOH 510 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 538 ? 1_555 144.2 ? 
56 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 74.9  ? 
57 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 91.2  ? 
58 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 135.1 ? 
59 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 98.1  ? 
60 O   ? L HOH .   ? A HOH 510 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 150.1 ? 
61 O   ? L HOH .   ? A HOH 538 ? 1_555 ZN ? F ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 639 ? 1_555 65.8  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 95  A . ? HIS 95  A THR 96  A ? THR 96  A 1 -2.92 
2 GLU 208 A . ? GLU 208 A PRO 209 A ? PRO 209 A 1 2.35  
3 TRP 241 A . ? TRP 241 A PRO 242 A ? PRO 242 A 1 -8.13 
4 TRP 273 A . ? TRP 273 A PRO 274 A ? PRO 274 A 1 -5.17 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA1 2 3  ? parallel      
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? parallel      
AA1 9 10 ? parallel      
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  HIS A 236 ? GLN A 238 ? HIS A 236 GLN A 238 
AA1 2  ASP A 260 ? SER A 269 ? ASP A 260 SER A 269 
AA1 3  ILE A 310 ? PHE A 315 ? ILE A 310 PHE A 315 
AA1 4  THR A 29  ? VAL A 34  ? THR A 29  VAL A 34  
AA1 5  SER A 54  ? ALA A 57  ? SER A 54  ALA A 57  
AA1 6  ASP A 91  ? VAL A 98  ? ASP A 91  VAL A 98  
AA1 7  TYR A 153 ? ASN A 158 ? TYR A 153 ASN A 158 
AA1 8  LYS A 197 ? ASP A 202 ? LYS A 197 ASP A 202 
AA1 9  GLY A 230 ? HIS A 233 ? GLY A 230 HIS A 233 
AA1 10 ASP A 260 ? SER A 269 ? ASP A 260 SER A 269 
AA2 1  VAL A 339 ? VAL A 340 ? VAL A 339 VAL A 340 
AA2 2  VAL A 331 ? TYR A 333 ? VAL A 331 TYR A 333 
AA2 3  LYS A 349 ? GLU A 351 ? LYS A 349 GLU A 351 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ILE A 237 ? N ILE A 237 O SER A 269 ? O SER A 269 
AA1 2 3  N ILE A 263 ? N ILE A 263 O THR A 314 ? O THR A 314 
AA1 3 4  O PHE A 315 ? O PHE A 315 N GLY A 31  ? N GLY A 31  
AA1 4 5  N VAL A 34  ? N VAL A 34  O VAL A 56  ? O VAL A 56  
AA1 5 6  N ILE A 55  ? N ILE A 55  O ARG A 93  ? O ARG A 93  
AA1 6 7  N PHE A 94  ? N PHE A 94  O ASP A 155 ? O ASP A 155 
AA1 7 8  N TRP A 154 ? N TRP A 154 O TYR A 199 ? O TYR A 199 
AA1 8 9  N MET A 200 ? N MET A 200 O GLY A 232 ? O GLY A 232 
AA1 9 10 N HIS A 233 ? N HIS A 233 O GLN A 262 ? O GLN A 262 
AA2 1 2  O VAL A 340 ? O VAL A 340 N TYR A 332 ? N TYR A 332 
AA2 2 3  N VAL A 331 ? N VAL A 331 O GLU A 351 ? O GLU A 351 
# 
_pdbx_entry_details.entry_id                   9FK3 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 282 ? ? O A HOH 501 ? ? 2.08 
2 1 O   A HOH 778 ? ? O A HOH 836 ? ? 2.15 
3 1 O   A HOH 705 ? ? O A HOH 841 ? ? 2.17 
4 1 O   A HOH 733 ? ? O A HOH 869 ? ? 2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 59  ? ? -145.24 -34.64 
2 1 ILE A 318 ? ? -103.55 -61.53 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     611 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   L 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       901 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.82 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A LYS 1 ? A LYS 1 
2 1 Y 1 A ASN 2 ? A ASN 2 
3 1 Y 1 A ALA 3 ? A ALA 3 
4 1 Y 1 A ASP 4 ? A ASP 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ID6 C1   C  N R 1   
A1ID6 C2   C  N R 2   
A1ID6 C3   C  N S 3   
A1ID6 C4   C  N R 4   
A1ID6 C5   C  N N 5   
A1ID6 O2   O  N N 6   
A1ID6 O3   O  N N 7   
A1ID6 O4   O  N N 8   
A1ID6 O5   O  N N 9   
A1ID6 F1   F  N N 10  
A1ID6 H1   H  N N 11  
A1ID6 H2   H  N N 12  
A1ID6 H3   H  N N 13  
A1ID6 H4   H  N N 14  
A1ID6 H51  H  N N 15  
A1ID6 H52  H  N N 16  
A1ID6 HO2  H  N N 17  
A1ID6 HO3  H  N N 18  
A1ID6 HO4  H  N N 19  
ALA   N    N  N N 20  
ALA   CA   C  N S 21  
ALA   C    C  N N 22  
ALA   O    O  N N 23  
ALA   CB   C  N N 24  
ALA   OXT  O  N N 25  
ALA   H    H  N N 26  
ALA   H2   H  N N 27  
ALA   HA   H  N N 28  
ALA   HB1  H  N N 29  
ALA   HB2  H  N N 30  
ALA   HB3  H  N N 31  
ALA   HXT  H  N N 32  
ARG   N    N  N N 33  
ARG   CA   C  N S 34  
ARG   C    C  N N 35  
ARG   O    O  N N 36  
ARG   CB   C  N N 37  
ARG   CG   C  N N 38  
ARG   CD   C  N N 39  
ARG   NE   N  N N 40  
ARG   CZ   C  N N 41  
ARG   NH1  N  N N 42  
ARG   NH2  N  N N 43  
ARG   OXT  O  N N 44  
ARG   H    H  N N 45  
ARG   H2   H  N N 46  
ARG   HA   H  N N 47  
ARG   HB2  H  N N 48  
ARG   HB3  H  N N 49  
ARG   HG2  H  N N 50  
ARG   HG3  H  N N 51  
ARG   HD2  H  N N 52  
ARG   HD3  H  N N 53  
ARG   HE   H  N N 54  
ARG   HH11 H  N N 55  
ARG   HH12 H  N N 56  
ARG   HH21 H  N N 57  
ARG   HH22 H  N N 58  
ARG   HXT  H  N N 59  
ASN   N    N  N N 60  
ASN   CA   C  N S 61  
ASN   C    C  N N 62  
ASN   O    O  N N 63  
ASN   CB   C  N N 64  
ASN   CG   C  N N 65  
ASN   OD1  O  N N 66  
ASN   ND2  N  N N 67  
ASN   OXT  O  N N 68  
ASN   H    H  N N 69  
ASN   H2   H  N N 70  
ASN   HA   H  N N 71  
ASN   HB2  H  N N 72  
ASN   HB3  H  N N 73  
ASN   HD21 H  N N 74  
ASN   HD22 H  N N 75  
ASN   HXT  H  N N 76  
ASP   N    N  N N 77  
ASP   CA   C  N S 78  
ASP   C    C  N N 79  
ASP   O    O  N N 80  
ASP   CB   C  N N 81  
ASP   CG   C  N N 82  
ASP   OD1  O  N N 83  
ASP   OD2  O  N N 84  
ASP   OXT  O  N N 85  
ASP   H    H  N N 86  
ASP   H2   H  N N 87  
ASP   HA   H  N N 88  
ASP   HB2  H  N N 89  
ASP   HB3  H  N N 90  
ASP   HD2  H  N N 91  
ASP   HXT  H  N N 92  
CL    CL   CL N N 93  
GLN   N    N  N N 94  
GLN   CA   C  N S 95  
GLN   C    C  N N 96  
GLN   O    O  N N 97  
GLN   CB   C  N N 98  
GLN   CG   C  N N 99  
GLN   CD   C  N N 100 
GLN   OE1  O  N N 101 
GLN   NE2  N  N N 102 
GLN   OXT  O  N N 103 
GLN   H    H  N N 104 
GLN   H2   H  N N 105 
GLN   HA   H  N N 106 
GLN   HB2  H  N N 107 
GLN   HB3  H  N N 108 
GLN   HG2  H  N N 109 
GLN   HG3  H  N N 110 
GLN   HE21 H  N N 111 
GLN   HE22 H  N N 112 
GLN   HXT  H  N N 113 
GLU   N    N  N N 114 
GLU   CA   C  N S 115 
GLU   C    C  N N 116 
GLU   O    O  N N 117 
GLU   CB   C  N N 118 
GLU   CG   C  N N 119 
GLU   CD   C  N N 120 
GLU   OE1  O  N N 121 
GLU   OE2  O  N N 122 
GLU   OXT  O  N N 123 
GLU   H    H  N N 124 
GLU   H2   H  N N 125 
GLU   HA   H  N N 126 
GLU   HB2  H  N N 127 
GLU   HB3  H  N N 128 
GLU   HG2  H  N N 129 
GLU   HG3  H  N N 130 
GLU   HE2  H  N N 131 
GLU   HXT  H  N N 132 
GLY   N    N  N N 133 
GLY   CA   C  N N 134 
GLY   C    C  N N 135 
GLY   O    O  N N 136 
GLY   OXT  O  N N 137 
GLY   H    H  N N 138 
GLY   H2   H  N N 139 
GLY   HA2  H  N N 140 
GLY   HA3  H  N N 141 
GLY   HXT  H  N N 142 
HIS   N    N  N N 143 
HIS   CA   C  N S 144 
HIS   C    C  N N 145 
HIS   O    O  N N 146 
HIS   CB   C  N N 147 
HIS   CG   C  Y N 148 
HIS   ND1  N  Y N 149 
HIS   CD2  C  Y N 150 
HIS   CE1  C  Y N 151 
HIS   NE2  N  Y N 152 
HIS   OXT  O  N N 153 
HIS   H    H  N N 154 
HIS   H2   H  N N 155 
HIS   HA   H  N N 156 
HIS   HB2  H  N N 157 
HIS   HB3  H  N N 158 
HIS   HD1  H  N N 159 
HIS   HD2  H  N N 160 
HIS   HE1  H  N N 161 
HIS   HE2  H  N N 162 
HIS   HXT  H  N N 163 
HOH   O    O  N N 164 
HOH   H1   H  N N 165 
HOH   H2   H  N N 166 
ILE   N    N  N N 167 
ILE   CA   C  N S 168 
ILE   C    C  N N 169 
ILE   O    O  N N 170 
ILE   CB   C  N S 171 
ILE   CG1  C  N N 172 
ILE   CG2  C  N N 173 
ILE   CD1  C  N N 174 
ILE   OXT  O  N N 175 
ILE   H    H  N N 176 
ILE   H2   H  N N 177 
ILE   HA   H  N N 178 
ILE   HB   H  N N 179 
ILE   HG12 H  N N 180 
ILE   HG13 H  N N 181 
ILE   HG21 H  N N 182 
ILE   HG22 H  N N 183 
ILE   HG23 H  N N 184 
ILE   HD11 H  N N 185 
ILE   HD12 H  N N 186 
ILE   HD13 H  N N 187 
ILE   HXT  H  N N 188 
LEU   N    N  N N 189 
LEU   CA   C  N S 190 
LEU   C    C  N N 191 
LEU   O    O  N N 192 
LEU   CB   C  N N 193 
LEU   CG   C  N N 194 
LEU   CD1  C  N N 195 
LEU   CD2  C  N N 196 
LEU   OXT  O  N N 197 
LEU   H    H  N N 198 
LEU   H2   H  N N 199 
LEU   HA   H  N N 200 
LEU   HB2  H  N N 201 
LEU   HB3  H  N N 202 
LEU   HG   H  N N 203 
LEU   HD11 H  N N 204 
LEU   HD12 H  N N 205 
LEU   HD13 H  N N 206 
LEU   HD21 H  N N 207 
LEU   HD22 H  N N 208 
LEU   HD23 H  N N 209 
LEU   HXT  H  N N 210 
LYS   N    N  N N 211 
LYS   CA   C  N S 212 
LYS   C    C  N N 213 
LYS   O    O  N N 214 
LYS   CB   C  N N 215 
LYS   CG   C  N N 216 
LYS   CD   C  N N 217 
LYS   CE   C  N N 218 
LYS   NZ   N  N N 219 
LYS   OXT  O  N N 220 
LYS   H    H  N N 221 
LYS   H2   H  N N 222 
LYS   HA   H  N N 223 
LYS   HB2  H  N N 224 
LYS   HB3  H  N N 225 
LYS   HG2  H  N N 226 
LYS   HG3  H  N N 227 
LYS   HD2  H  N N 228 
LYS   HD3  H  N N 229 
LYS   HE2  H  N N 230 
LYS   HE3  H  N N 231 
LYS   HZ1  H  N N 232 
LYS   HZ2  H  N N 233 
LYS   HZ3  H  N N 234 
LYS   HXT  H  N N 235 
MET   N    N  N N 236 
MET   CA   C  N S 237 
MET   C    C  N N 238 
MET   O    O  N N 239 
MET   CB   C  N N 240 
MET   CG   C  N N 241 
MET   SD   S  N N 242 
MET   CE   C  N N 243 
MET   OXT  O  N N 244 
MET   H    H  N N 245 
MET   H2   H  N N 246 
MET   HA   H  N N 247 
MET   HB2  H  N N 248 
MET   HB3  H  N N 249 
MET   HG2  H  N N 250 
MET   HG3  H  N N 251 
MET   HE1  H  N N 252 
MET   HE2  H  N N 253 
MET   HE3  H  N N 254 
MET   HXT  H  N N 255 
PHE   N    N  N N 256 
PHE   CA   C  N S 257 
PHE   C    C  N N 258 
PHE   O    O  N N 259 
PHE   CB   C  N N 260 
PHE   CG   C  Y N 261 
PHE   CD1  C  Y N 262 
PHE   CD2  C  Y N 263 
PHE   CE1  C  Y N 264 
PHE   CE2  C  Y N 265 
PHE   CZ   C  Y N 266 
PHE   OXT  O  N N 267 
PHE   H    H  N N 268 
PHE   H2   H  N N 269 
PHE   HA   H  N N 270 
PHE   HB2  H  N N 271 
PHE   HB3  H  N N 272 
PHE   HD1  H  N N 273 
PHE   HD2  H  N N 274 
PHE   HE1  H  N N 275 
PHE   HE2  H  N N 276 
PHE   HZ   H  N N 277 
PHE   HXT  H  N N 278 
PRO   N    N  N N 279 
PRO   CA   C  N S 280 
PRO   C    C  N N 281 
PRO   O    O  N N 282 
PRO   CB   C  N N 283 
PRO   CG   C  N N 284 
PRO   CD   C  N N 285 
PRO   OXT  O  N N 286 
PRO   H    H  N N 287 
PRO   HA   H  N N 288 
PRO   HB2  H  N N 289 
PRO   HB3  H  N N 290 
PRO   HG2  H  N N 291 
PRO   HG3  H  N N 292 
PRO   HD2  H  N N 293 
PRO   HD3  H  N N 294 
PRO   HXT  H  N N 295 
SER   N    N  N N 296 
SER   CA   C  N S 297 
SER   C    C  N N 298 
SER   O    O  N N 299 
SER   CB   C  N N 300 
SER   OG   O  N N 301 
SER   OXT  O  N N 302 
SER   H    H  N N 303 
SER   H2   H  N N 304 
SER   HA   H  N N 305 
SER   HB2  H  N N 306 
SER   HB3  H  N N 307 
SER   HG   H  N N 308 
SER   HXT  H  N N 309 
THR   N    N  N N 310 
THR   CA   C  N S 311 
THR   C    C  N N 312 
THR   O    O  N N 313 
THR   CB   C  N R 314 
THR   OG1  O  N N 315 
THR   CG2  C  N N 316 
THR   OXT  O  N N 317 
THR   H    H  N N 318 
THR   H2   H  N N 319 
THR   HA   H  N N 320 
THR   HB   H  N N 321 
THR   HG1  H  N N 322 
THR   HG21 H  N N 323 
THR   HG22 H  N N 324 
THR   HG23 H  N N 325 
THR   HXT  H  N N 326 
TRP   N    N  N N 327 
TRP   CA   C  N S 328 
TRP   C    C  N N 329 
TRP   O    O  N N 330 
TRP   CB   C  N N 331 
TRP   CG   C  Y N 332 
TRP   CD1  C  Y N 333 
TRP   CD2  C  Y N 334 
TRP   NE1  N  Y N 335 
TRP   CE2  C  Y N 336 
TRP   CE3  C  Y N 337 
TRP   CZ2  C  Y N 338 
TRP   CZ3  C  Y N 339 
TRP   CH2  C  Y N 340 
TRP   OXT  O  N N 341 
TRP   H    H  N N 342 
TRP   H2   H  N N 343 
TRP   HA   H  N N 344 
TRP   HB2  H  N N 345 
TRP   HB3  H  N N 346 
TRP   HD1  H  N N 347 
TRP   HE1  H  N N 348 
TRP   HE3  H  N N 349 
TRP   HZ2  H  N N 350 
TRP   HZ3  H  N N 351 
TRP   HH2  H  N N 352 
TRP   HXT  H  N N 353 
TYR   N    N  N N 354 
TYR   CA   C  N S 355 
TYR   C    C  N N 356 
TYR   O    O  N N 357 
TYR   CB   C  N N 358 
TYR   CG   C  Y N 359 
TYR   CD1  C  Y N 360 
TYR   CD2  C  Y N 361 
TYR   CE1  C  Y N 362 
TYR   CE2  C  Y N 363 
TYR   CZ   C  Y N 364 
TYR   OH   O  N N 365 
TYR   OXT  O  N N 366 
TYR   H    H  N N 367 
TYR   H2   H  N N 368 
TYR   HA   H  N N 369 
TYR   HB2  H  N N 370 
TYR   HB3  H  N N 371 
TYR   HD1  H  N N 372 
TYR   HD2  H  N N 373 
TYR   HE1  H  N N 374 
TYR   HE2  H  N N 375 
TYR   HH   H  N N 376 
TYR   HXT  H  N N 377 
VAL   N    N  N N 378 
VAL   CA   C  N S 379 
VAL   C    C  N N 380 
VAL   O    O  N N 381 
VAL   CB   C  N N 382 
VAL   CG1  C  N N 383 
VAL   CG2  C  N N 384 
VAL   OXT  O  N N 385 
VAL   H    H  N N 386 
VAL   H2   H  N N 387 
VAL   HA   H  N N 388 
VAL   HB   H  N N 389 
VAL   HG11 H  N N 390 
VAL   HG12 H  N N 391 
VAL   HG13 H  N N 392 
VAL   HG21 H  N N 393 
VAL   HG22 H  N N 394 
VAL   HG23 H  N N 395 
VAL   HXT  H  N N 396 
XYP   O1   O  N N 397 
XYP   C1   C  N R 398 
XYP   C2   C  N R 399 
XYP   C3   C  N S 400 
XYP   C4   C  N R 401 
XYP   C5   C  N N 402 
XYP   O2   O  N N 403 
XYP   O3   O  N N 404 
XYP   O4   O  N N 405 
XYP   O5   O  N N 406 
XYP   HO1  H  N N 407 
XYP   H1   H  N N 408 
XYP   H2   H  N N 409 
XYP   H3   H  N N 410 
XYP   H4   H  N N 411 
XYP   H51  H  N N 412 
XYP   H52  H  N N 413 
XYP   HO2  H  N N 414 
XYP   HO3  H  N N 415 
XYP   HO4  H  N N 416 
ZN    ZN   ZN N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ID6 F1  C1   sing N N 1   
A1ID6 O4  C4   sing N N 2   
A1ID6 C5  C4   sing N N 3   
A1ID6 C5  O5   sing N N 4   
A1ID6 C4  C3   sing N N 5   
A1ID6 C3  O3   sing N N 6   
A1ID6 C3  C2   sing N N 7   
A1ID6 O5  C1   sing N N 8   
A1ID6 C1  C2   sing N N 9   
A1ID6 C2  O2   sing N N 10  
A1ID6 C1  H1   sing N N 11  
A1ID6 C2  H2   sing N N 12  
A1ID6 C3  H3   sing N N 13  
A1ID6 C4  H4   sing N N 14  
A1ID6 C5  H51  sing N N 15  
A1ID6 C5  H52  sing N N 16  
A1ID6 O2  HO2  sing N N 17  
A1ID6 O3  HO3  sing N N 18  
A1ID6 O4  HO4  sing N N 19  
ALA   N   CA   sing N N 20  
ALA   N   H    sing N N 21  
ALA   N   H2   sing N N 22  
ALA   CA  C    sing N N 23  
ALA   CA  CB   sing N N 24  
ALA   CA  HA   sing N N 25  
ALA   C   O    doub N N 26  
ALA   C   OXT  sing N N 27  
ALA   CB  HB1  sing N N 28  
ALA   CB  HB2  sing N N 29  
ALA   CB  HB3  sing N N 30  
ALA   OXT HXT  sing N N 31  
ARG   N   CA   sing N N 32  
ARG   N   H    sing N N 33  
ARG   N   H2   sing N N 34  
ARG   CA  C    sing N N 35  
ARG   CA  CB   sing N N 36  
ARG   CA  HA   sing N N 37  
ARG   C   O    doub N N 38  
ARG   C   OXT  sing N N 39  
ARG   CB  CG   sing N N 40  
ARG   CB  HB2  sing N N 41  
ARG   CB  HB3  sing N N 42  
ARG   CG  CD   sing N N 43  
ARG   CG  HG2  sing N N 44  
ARG   CG  HG3  sing N N 45  
ARG   CD  NE   sing N N 46  
ARG   CD  HD2  sing N N 47  
ARG   CD  HD3  sing N N 48  
ARG   NE  CZ   sing N N 49  
ARG   NE  HE   sing N N 50  
ARG   CZ  NH1  sing N N 51  
ARG   CZ  NH2  doub N N 52  
ARG   NH1 HH11 sing N N 53  
ARG   NH1 HH12 sing N N 54  
ARG   NH2 HH21 sing N N 55  
ARG   NH2 HH22 sing N N 56  
ARG   OXT HXT  sing N N 57  
ASN   N   CA   sing N N 58  
ASN   N   H    sing N N 59  
ASN   N   H2   sing N N 60  
ASN   CA  C    sing N N 61  
ASN   CA  CB   sing N N 62  
ASN   CA  HA   sing N N 63  
ASN   C   O    doub N N 64  
ASN   C   OXT  sing N N 65  
ASN   CB  CG   sing N N 66  
ASN   CB  HB2  sing N N 67  
ASN   CB  HB3  sing N N 68  
ASN   CG  OD1  doub N N 69  
ASN   CG  ND2  sing N N 70  
ASN   ND2 HD21 sing N N 71  
ASN   ND2 HD22 sing N N 72  
ASN   OXT HXT  sing N N 73  
ASP   N   CA   sing N N 74  
ASP   N   H    sing N N 75  
ASP   N   H2   sing N N 76  
ASP   CA  C    sing N N 77  
ASP   CA  CB   sing N N 78  
ASP   CA  HA   sing N N 79  
ASP   C   O    doub N N 80  
ASP   C   OXT  sing N N 81  
ASP   CB  CG   sing N N 82  
ASP   CB  HB2  sing N N 83  
ASP   CB  HB3  sing N N 84  
ASP   CG  OD1  doub N N 85  
ASP   CG  OD2  sing N N 86  
ASP   OD2 HD2  sing N N 87  
ASP   OXT HXT  sing N N 88  
GLN   N   CA   sing N N 89  
GLN   N   H    sing N N 90  
GLN   N   H2   sing N N 91  
GLN   CA  C    sing N N 92  
GLN   CA  CB   sing N N 93  
GLN   CA  HA   sing N N 94  
GLN   C   O    doub N N 95  
GLN   C   OXT  sing N N 96  
GLN   CB  CG   sing N N 97  
GLN   CB  HB2  sing N N 98  
GLN   CB  HB3  sing N N 99  
GLN   CG  CD   sing N N 100 
GLN   CG  HG2  sing N N 101 
GLN   CG  HG3  sing N N 102 
GLN   CD  OE1  doub N N 103 
GLN   CD  NE2  sing N N 104 
GLN   NE2 HE21 sing N N 105 
GLN   NE2 HE22 sing N N 106 
GLN   OXT HXT  sing N N 107 
GLU   N   CA   sing N N 108 
GLU   N   H    sing N N 109 
GLU   N   H2   sing N N 110 
GLU   CA  C    sing N N 111 
GLU   CA  CB   sing N N 112 
GLU   CA  HA   sing N N 113 
GLU   C   O    doub N N 114 
GLU   C   OXT  sing N N 115 
GLU   CB  CG   sing N N 116 
GLU   CB  HB2  sing N N 117 
GLU   CB  HB3  sing N N 118 
GLU   CG  CD   sing N N 119 
GLU   CG  HG2  sing N N 120 
GLU   CG  HG3  sing N N 121 
GLU   CD  OE1  doub N N 122 
GLU   CD  OE2  sing N N 123 
GLU   OE2 HE2  sing N N 124 
GLU   OXT HXT  sing N N 125 
GLY   N   CA   sing N N 126 
GLY   N   H    sing N N 127 
GLY   N   H2   sing N N 128 
GLY   CA  C    sing N N 129 
GLY   CA  HA2  sing N N 130 
GLY   CA  HA3  sing N N 131 
GLY   C   O    doub N N 132 
GLY   C   OXT  sing N N 133 
GLY   OXT HXT  sing N N 134 
HIS   N   CA   sing N N 135 
HIS   N   H    sing N N 136 
HIS   N   H2   sing N N 137 
HIS   CA  C    sing N N 138 
HIS   CA  CB   sing N N 139 
HIS   CA  HA   sing N N 140 
HIS   C   O    doub N N 141 
HIS   C   OXT  sing N N 142 
HIS   CB  CG   sing N N 143 
HIS   CB  HB2  sing N N 144 
HIS   CB  HB3  sing N N 145 
HIS   CG  ND1  sing Y N 146 
HIS   CG  CD2  doub Y N 147 
HIS   ND1 CE1  doub Y N 148 
HIS   ND1 HD1  sing N N 149 
HIS   CD2 NE2  sing Y N 150 
HIS   CD2 HD2  sing N N 151 
HIS   CE1 NE2  sing Y N 152 
HIS   CE1 HE1  sing N N 153 
HIS   NE2 HE2  sing N N 154 
HIS   OXT HXT  sing N N 155 
HOH   O   H1   sing N N 156 
HOH   O   H2   sing N N 157 
ILE   N   CA   sing N N 158 
ILE   N   H    sing N N 159 
ILE   N   H2   sing N N 160 
ILE   CA  C    sing N N 161 
ILE   CA  CB   sing N N 162 
ILE   CA  HA   sing N N 163 
ILE   C   O    doub N N 164 
ILE   C   OXT  sing N N 165 
ILE   CB  CG1  sing N N 166 
ILE   CB  CG2  sing N N 167 
ILE   CB  HB   sing N N 168 
ILE   CG1 CD1  sing N N 169 
ILE   CG1 HG12 sing N N 170 
ILE   CG1 HG13 sing N N 171 
ILE   CG2 HG21 sing N N 172 
ILE   CG2 HG22 sing N N 173 
ILE   CG2 HG23 sing N N 174 
ILE   CD1 HD11 sing N N 175 
ILE   CD1 HD12 sing N N 176 
ILE   CD1 HD13 sing N N 177 
ILE   OXT HXT  sing N N 178 
LEU   N   CA   sing N N 179 
LEU   N   H    sing N N 180 
LEU   N   H2   sing N N 181 
LEU   CA  C    sing N N 182 
LEU   CA  CB   sing N N 183 
LEU   CA  HA   sing N N 184 
LEU   C   O    doub N N 185 
LEU   C   OXT  sing N N 186 
LEU   CB  CG   sing N N 187 
LEU   CB  HB2  sing N N 188 
LEU   CB  HB3  sing N N 189 
LEU   CG  CD1  sing N N 190 
LEU   CG  CD2  sing N N 191 
LEU   CG  HG   sing N N 192 
LEU   CD1 HD11 sing N N 193 
LEU   CD1 HD12 sing N N 194 
LEU   CD1 HD13 sing N N 195 
LEU   CD2 HD21 sing N N 196 
LEU   CD2 HD22 sing N N 197 
LEU   CD2 HD23 sing N N 198 
LEU   OXT HXT  sing N N 199 
LYS   N   CA   sing N N 200 
LYS   N   H    sing N N 201 
LYS   N   H2   sing N N 202 
LYS   CA  C    sing N N 203 
LYS   CA  CB   sing N N 204 
LYS   CA  HA   sing N N 205 
LYS   C   O    doub N N 206 
LYS   C   OXT  sing N N 207 
LYS   CB  CG   sing N N 208 
LYS   CB  HB2  sing N N 209 
LYS   CB  HB3  sing N N 210 
LYS   CG  CD   sing N N 211 
LYS   CG  HG2  sing N N 212 
LYS   CG  HG3  sing N N 213 
LYS   CD  CE   sing N N 214 
LYS   CD  HD2  sing N N 215 
LYS   CD  HD3  sing N N 216 
LYS   CE  NZ   sing N N 217 
LYS   CE  HE2  sing N N 218 
LYS   CE  HE3  sing N N 219 
LYS   NZ  HZ1  sing N N 220 
LYS   NZ  HZ2  sing N N 221 
LYS   NZ  HZ3  sing N N 222 
LYS   OXT HXT  sing N N 223 
MET   N   CA   sing N N 224 
MET   N   H    sing N N 225 
MET   N   H2   sing N N 226 
MET   CA  C    sing N N 227 
MET   CA  CB   sing N N 228 
MET   CA  HA   sing N N 229 
MET   C   O    doub N N 230 
MET   C   OXT  sing N N 231 
MET   CB  CG   sing N N 232 
MET   CB  HB2  sing N N 233 
MET   CB  HB3  sing N N 234 
MET   CG  SD   sing N N 235 
MET   CG  HG2  sing N N 236 
MET   CG  HG3  sing N N 237 
MET   SD  CE   sing N N 238 
MET   CE  HE1  sing N N 239 
MET   CE  HE2  sing N N 240 
MET   CE  HE3  sing N N 241 
MET   OXT HXT  sing N N 242 
PHE   N   CA   sing N N 243 
PHE   N   H    sing N N 244 
PHE   N   H2   sing N N 245 
PHE   CA  C    sing N N 246 
PHE   CA  CB   sing N N 247 
PHE   CA  HA   sing N N 248 
PHE   C   O    doub N N 249 
PHE   C   OXT  sing N N 250 
PHE   CB  CG   sing N N 251 
PHE   CB  HB2  sing N N 252 
PHE   CB  HB3  sing N N 253 
PHE   CG  CD1  doub Y N 254 
PHE   CG  CD2  sing Y N 255 
PHE   CD1 CE1  sing Y N 256 
PHE   CD1 HD1  sing N N 257 
PHE   CD2 CE2  doub Y N 258 
PHE   CD2 HD2  sing N N 259 
PHE   CE1 CZ   doub Y N 260 
PHE   CE1 HE1  sing N N 261 
PHE   CE2 CZ   sing Y N 262 
PHE   CE2 HE2  sing N N 263 
PHE   CZ  HZ   sing N N 264 
PHE   OXT HXT  sing N N 265 
PRO   N   CA   sing N N 266 
PRO   N   CD   sing N N 267 
PRO   N   H    sing N N 268 
PRO   CA  C    sing N N 269 
PRO   CA  CB   sing N N 270 
PRO   CA  HA   sing N N 271 
PRO   C   O    doub N N 272 
PRO   C   OXT  sing N N 273 
PRO   CB  CG   sing N N 274 
PRO   CB  HB2  sing N N 275 
PRO   CB  HB3  sing N N 276 
PRO   CG  CD   sing N N 277 
PRO   CG  HG2  sing N N 278 
PRO   CG  HG3  sing N N 279 
PRO   CD  HD2  sing N N 280 
PRO   CD  HD3  sing N N 281 
PRO   OXT HXT  sing N N 282 
SER   N   CA   sing N N 283 
SER   N   H    sing N N 284 
SER   N   H2   sing N N 285 
SER   CA  C    sing N N 286 
SER   CA  CB   sing N N 287 
SER   CA  HA   sing N N 288 
SER   C   O    doub N N 289 
SER   C   OXT  sing N N 290 
SER   CB  OG   sing N N 291 
SER   CB  HB2  sing N N 292 
SER   CB  HB3  sing N N 293 
SER   OG  HG   sing N N 294 
SER   OXT HXT  sing N N 295 
THR   N   CA   sing N N 296 
THR   N   H    sing N N 297 
THR   N   H2   sing N N 298 
THR   CA  C    sing N N 299 
THR   CA  CB   sing N N 300 
THR   CA  HA   sing N N 301 
THR   C   O    doub N N 302 
THR   C   OXT  sing N N 303 
THR   CB  OG1  sing N N 304 
THR   CB  CG2  sing N N 305 
THR   CB  HB   sing N N 306 
THR   OG1 HG1  sing N N 307 
THR   CG2 HG21 sing N N 308 
THR   CG2 HG22 sing N N 309 
THR   CG2 HG23 sing N N 310 
THR   OXT HXT  sing N N 311 
TRP   N   CA   sing N N 312 
TRP   N   H    sing N N 313 
TRP   N   H2   sing N N 314 
TRP   CA  C    sing N N 315 
TRP   CA  CB   sing N N 316 
TRP   CA  HA   sing N N 317 
TRP   C   O    doub N N 318 
TRP   C   OXT  sing N N 319 
TRP   CB  CG   sing N N 320 
TRP   CB  HB2  sing N N 321 
TRP   CB  HB3  sing N N 322 
TRP   CG  CD1  doub Y N 323 
TRP   CG  CD2  sing Y N 324 
TRP   CD1 NE1  sing Y N 325 
TRP   CD1 HD1  sing N N 326 
TRP   CD2 CE2  doub Y N 327 
TRP   CD2 CE3  sing Y N 328 
TRP   NE1 CE2  sing Y N 329 
TRP   NE1 HE1  sing N N 330 
TRP   CE2 CZ2  sing Y N 331 
TRP   CE3 CZ3  doub Y N 332 
TRP   CE3 HE3  sing N N 333 
TRP   CZ2 CH2  doub Y N 334 
TRP   CZ2 HZ2  sing N N 335 
TRP   CZ3 CH2  sing Y N 336 
TRP   CZ3 HZ3  sing N N 337 
TRP   CH2 HH2  sing N N 338 
TRP   OXT HXT  sing N N 339 
TYR   N   CA   sing N N 340 
TYR   N   H    sing N N 341 
TYR   N   H2   sing N N 342 
TYR   CA  C    sing N N 343 
TYR   CA  CB   sing N N 344 
TYR   CA  HA   sing N N 345 
TYR   C   O    doub N N 346 
TYR   C   OXT  sing N N 347 
TYR   CB  CG   sing N N 348 
TYR   CB  HB2  sing N N 349 
TYR   CB  HB3  sing N N 350 
TYR   CG  CD1  doub Y N 351 
TYR   CG  CD2  sing Y N 352 
TYR   CD1 CE1  sing Y N 353 
TYR   CD1 HD1  sing N N 354 
TYR   CD2 CE2  doub Y N 355 
TYR   CD2 HD2  sing N N 356 
TYR   CE1 CZ   doub Y N 357 
TYR   CE1 HE1  sing N N 358 
TYR   CE2 CZ   sing Y N 359 
TYR   CE2 HE2  sing N N 360 
TYR   CZ  OH   sing N N 361 
TYR   OH  HH   sing N N 362 
TYR   OXT HXT  sing N N 363 
VAL   N   CA   sing N N 364 
VAL   N   H    sing N N 365 
VAL   N   H2   sing N N 366 
VAL   CA  C    sing N N 367 
VAL   CA  CB   sing N N 368 
VAL   CA  HA   sing N N 369 
VAL   C   O    doub N N 370 
VAL   C   OXT  sing N N 371 
VAL   CB  CG1  sing N N 372 
VAL   CB  CG2  sing N N 373 
VAL   CB  HB   sing N N 374 
VAL   CG1 HG11 sing N N 375 
VAL   CG1 HG12 sing N N 376 
VAL   CG1 HG13 sing N N 377 
VAL   CG2 HG21 sing N N 378 
VAL   CG2 HG22 sing N N 379 
VAL   CG2 HG23 sing N N 380 
VAL   OXT HXT  sing N N 381 
XYP   O1  C1   sing N N 382 
XYP   O1  HO1  sing N N 383 
XYP   C1  C2   sing N N 384 
XYP   C1  O5   sing N N 385 
XYP   C1  H1   sing N N 386 
XYP   C2  C3   sing N N 387 
XYP   C2  O2   sing N N 388 
XYP   C2  H2   sing N N 389 
XYP   C3  C4   sing N N 390 
XYP   C3  O3   sing N N 391 
XYP   C3  H3   sing N N 392 
XYP   C4  C5   sing N N 393 
XYP   C4  O4   sing N N 394 
XYP   C4  H4   sing N N 395 
XYP   C5  O5   sing N N 396 
XYP   C5  H51  sing N N 397 
XYP   C5  H52  sing N N 398 
XYP   O2  HO2  sing N N 399 
XYP   O3  HO3  sing N N 400 
XYP   O4  HO4  sing N N 401 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 A1ID6 1 n 
2 XYP   2 n 
3 A1ID6 1 n 
3 XYP   2 n 
3 XYP   3 n 
3 XYP   4 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9FK1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FK3 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011162 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003043 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016155 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009368 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428  4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER   A 1 5   ? -4.26465  30.51033 -25.93131 1.000 35.76687 ? 5   SER   A N   1 
ATOM   2    C  CA  . SER   A 1 5   ? -4.01982  29.58756 -27.03865 1.000 57.33162 ? 5   SER   A CA  1 
ATOM   3    C  C   . SER   A 1 5   ? -3.83856  30.29751 -28.39619 1.000 82.65272 ? 5   SER   A C   1 
ATOM   4    O  O   . SER   A 1 5   ? -2.70635  30.66392 -28.76068 1.000 81.20975 ? 5   SER   A O   1 
ATOM   5    C  CB  . SER   A 1 5   ? -5.14646  28.56341 -27.12562 1.000 37.03644 ? 5   SER   A CB  1 
ATOM   6    O  OG  . SER   A 1 5   ? -5.40377  28.18495 -28.46406 1.000 50.58579 ? 5   SER   A OG  1 
ATOM   7    N  N   . TYR   A 1 6   ? -4.93188  30.48115 -29.15613 1.000 76.71039 ? 6   TYR   A N   1 
ATOM   8    C  CA  . TYR   A 1 6   ? -4.86226  31.09058 -30.48944 1.000 69.24486 ? 6   TYR   A CA  1 
ATOM   9    C  C   . TYR   A 1 6   ? -5.53917  32.45824 -30.45288 1.000 67.48528 ? 6   TYR   A C   1 
ATOM   10   O  O   . TYR   A 1 6   ? -6.76637  32.55986 -30.55761 1.000 55.06585 ? 6   TYR   A O   1 
ATOM   11   C  CB  . TYR   A 1 6   ? -5.48341  30.18466 -31.54978 1.000 62.93467 ? 6   TYR   A CB  1 
ATOM   12   C  CG  . TYR   A 1 6   ? -4.49531  29.18632 -32.10389 1.000 66.47712 ? 6   TYR   A CG  1 
ATOM   13   C  CD1 . TYR   A 1 6   ? -3.73650  28.39328 -31.24664 1.000 74.47758 ? 6   TYR   A CD1 1 
ATOM   14   C  CD2 . TYR   A 1 6   ? -4.30274  29.04524 -33.47108 1.000 66.33795 ? 6   TYR   A CD2 1 
ATOM   15   C  CE1 . TYR   A 1 6   ? -2.81855  27.47649 -31.72857 1.000 74.69487 ? 6   TYR   A CE1 1 
ATOM   16   C  CE2 . TYR   A 1 6   ? -3.38421  28.12627 -33.96938 1.000 77.78483 ? 6   TYR   A CE2 1 
ATOM   17   C  CZ  . TYR   A 1 6   ? -2.64353  27.34439 -33.08806 1.000 80.38261 ? 6   TYR   A CZ  1 
ATOM   18   O  OH  . TYR   A 1 6   ? -1.72255  26.42893 -33.55569 1.000 80.32497 ? 6   TYR   A OH  1 
ATOM   19   N  N   . ALA   A 1 7   ? -4.72386  33.50768 -30.30291 1.000 65.33781 ? 7   ALA   A N   1 
ATOM   20   C  CA  . ALA   A 1 7   ? -5.18440  34.88398 -30.42197 1.000 63.03852 ? 7   ALA   A CA  1 
ATOM   21   C  C   . ALA   A 1 7   ? -5.38496  35.31842 -31.87130 1.000 62.51764 ? 7   ALA   A C   1 
ATOM   22   O  O   . ALA   A 1 7   ? -5.91622  36.41152 -32.11123 1.000 64.96436 ? 7   ALA   A O   1 
ATOM   23   C  CB  . ALA   A 1 7   ? -4.19498  35.83184 -29.74193 1.000 62.74333 ? 7   ALA   A CB  1 
ATOM   24   N  N   . LYS   A 1 8   ? -4.96885  34.50050 -32.84245 1.000 61.26615 ? 8   LYS   A N   1 
ATOM   25   C  CA  . LYS   A 1 8   ? -5.26261  34.80157 -34.24009 1.000 61.70912 ? 8   LYS   A CA  1 
ATOM   26   C  C   . LYS   A 1 8   ? -6.74564  34.59121 -34.54359 1.000 54.15499 ? 8   LYS   A C   1 
ATOM   27   O  O   . LYS   A 1 8   ? -7.31841  35.27998 -35.39905 1.000 47.14481 ? 8   LYS   A O   1 
ATOM   28   C  CB  . LYS   A 1 8   ? -4.39403  33.93290 -35.15241 1.000 59.26025 ? 8   LYS   A CB  1 
ATOM   29   C  CG  . LYS   A 1 8   ? -4.53654  34.26150 -36.63733 1.000 65.53363 ? 8   LYS   A CG  1 
ATOM   30   C  CD  . LYS   A 1 8   ? -3.49383  33.55048 -37.50028 1.000 65.26244 ? 8   LYS   A CD  1 
ATOM   31   C  CE  . LYS   A 1 8   ? -2.22613  34.39706 -37.65626 1.000 68.74125 ? 8   LYS   A CE  1 
ATOM   32   N  NZ  . LYS   A 1 8   ? -0.93981  33.61547 -37.71161 1.000 61.12348 ? 8   LYS   A NZ  1 
ATOM   33   N  N   . LYS   A 1 9   ? -7.38693  33.66318 -33.82796 1.000 38.63000 ? 9   LYS   A N   1 
ATOM   34   C  CA  . LYS   A 1 9   ? -8.77166  33.34917 -34.09817 1.000 31.17197 ? 9   LYS   A CA  1 
ATOM   35   C  C   . LYS   A 1 9   ? -9.68524  34.49994 -33.66577 1.000 27.44560 ? 9   LYS   A C   1 
ATOM   36   O  O   . LYS   A 1 9   ? -9.42474  35.19049 -32.67649 1.000 22.88827 ? 9   LYS   A O   1 
ATOM   37   C  CB  . LYS   A 1 9   ? -9.14812  32.03679 -33.41772 1.000 34.65567 ? 9   LYS   A CB  1 
ATOM   38   C  CG  . LYS   A 1 9   ? -8.34182  30.82335 -33.95452 1.000 34.96177 ? 9   LYS   A CG  1 
ATOM   39   C  CD  . LYS   A 1 9   ? -9.18520  29.54793 -34.13381 1.000 42.41793 ? 9   LYS   A CD  1 
ATOM   40   C  CE  . LYS   A 1 9   ? -10.16393 29.64145 -35.32047 1.000 47.58910 ? 9   LYS   A CE  1 
ATOM   41   N  NZ  . LYS   A 1 9   ? -9.57551  29.38757 -36.67962 1.000 57.42417 ? 9   LYS   A NZ  1 
ATOM   42   N  N   . PRO   A 1 10  ? -10.76127 34.73245 -34.40357 1.000 21.78830 ? 10  PRO   A N   1 
ATOM   43   C  CA  . PRO   A 1 10  ? -11.45144 36.02265 -34.33376 1.000 17.90273 ? 10  PRO   A CA  1 
ATOM   44   C  C   . PRO   A 1 10  ? -12.42879 36.15316 -33.16342 1.000 15.77727 ? 10  PRO   A C   1 
ATOM   45   O  O   . PRO   A 1 10  ? -12.91368 35.17434 -32.58633 1.000 14.71229 ? 10  PRO   A O   1 
ATOM   46   C  CB  . PRO   A 1 10  ? -12.19873 36.06939 -35.66905 1.000 17.17342 ? 10  PRO   A CB  1 
ATOM   47   C  CG  . PRO   A 1 10  ? -12.57439 34.62814 -35.88135 1.000 21.82046 ? 10  PRO   A CG  1 
ATOM   48   C  CD  . PRO   A 1 10  ? -11.44374 33.80030 -35.31772 1.000 21.95626 ? 10  PRO   A CD  1 
ATOM   49   N  N   . HIS   A 1 11  ? -12.70489 37.41767 -32.83594 1.000 15.10108 ? 11  HIS   A N   1 
ATOM   50   C  CA  . HIS   A 1 11  ? -13.63593 37.85460 -31.79088 1.000 13.90105 ? 11  HIS   A CA  1 
ATOM   51   C  C   . HIS   A 1 11  ? -15.05722 37.88374 -32.36791 1.000 14.59398 ? 11  HIS   A C   1 
ATOM   52   O  O   . HIS   A 1 11  ? -15.69355 38.92602 -32.48478 1.000 15.52249 ? 11  HIS   A O   1 
ATOM   53   C  CB  . HIS   A 1 11  ? -13.16894 39.23096 -31.31531 1.000 14.36271 ? 11  HIS   A CB  1 
ATOM   54   C  CG  . HIS   A 1 11  ? -13.83687 39.77444 -30.07517 1.000 14.44182 ? 11  HIS   A CG  1 
ATOM   55   N  ND1 . HIS   A 1 11  ? -13.90657 39.08486 -28.88205 1.000 12.58846 ? 11  HIS   A ND1 1 
ATOM   56   C  CD2 . HIS   A 1 11  ? -14.37077 40.99612 -29.82721 1.000 11.17985 ? 11  HIS   A CD2 1 
ATOM   57   C  CE1 . HIS   A 1 11  ? -14.48692 39.84270 -27.96763 1.000 14.42305 ? 11  HIS   A CE1 1 
ATOM   58   N  NE2 . HIS   A 1 11  ? -14.77755 41.00995 -28.51477 1.000 12.82653 ? 11  HIS   A NE2 1 
ATOM   59   N  N   . ILE   A 1 12  ? -15.54249 36.71635 -32.79161 1.000 12.83612 ? 12  ILE   A N   1 
ATOM   60   C  CA  . ILE   A 1 12  ? -16.88710 36.64831 -33.37426 1.000 15.33698 ? 12  ILE   A CA  1 
ATOM   61   C  C   . ILE   A 1 12  ? -17.94771 36.57176 -32.27405 1.000 14.85877 ? 12  ILE   A C   1 
ATOM   62   O  O   . ILE   A 1 12  ? -17.67226 36.26118 -31.11422 1.000 14.15226 ? 12  ILE   A O   1 
ATOM   63   C  CB  . ILE   A 1 12  ? -17.01539 35.46316 -34.34545 1.000 16.18930 ? 12  ILE   A CB  1 
ATOM   64   C  CG1 . ILE   A 1 12  ? -16.80144 34.14442 -33.59400 1.000 16.11656 ? 12  ILE   A CG1 1 
ATOM   65   C  CG2 . ILE   A 1 12  ? -16.02206 35.60302 -35.49239 1.000 20.74278 ? 12  ILE   A CG2 1 
ATOM   66   C  CD1 . ILE   A 1 12  ? -17.04558 32.91678 -34.43265 1.000 15.02259 ? 12  ILE   A CD1 1 
ATOM   67   N  N   . SER   A 1 13  ? -19.18796 36.85569 -32.66142 1.000 13.51604 ? 13  SER   A N   1 
ATOM   68   C  CA  . SER   A 1 13  ? -20.33933 36.61052 -31.79889 1.000 16.01952 ? 13  SER   A CA  1 
ATOM   69   C  C   . SER   A 1 13  ? -20.39033 35.16888 -31.30041 1.000 18.73037 ? 13  SER   A C   1 
ATOM   70   O  O   . SER   A 1 13  ? -20.28855 34.22206 -32.08472 1.000 17.43351 ? 13  SER   A O   1 
ATOM   71   C  CB  . SER   A 1 13  ? -21.63630 36.92578 -32.54399 1.000 14.48624 ? 13  SER   A CB  1 
ATOM   72   O  OG  . SER   A 1 13  ? -22.74284 36.70520 -31.68973 1.000 17.59764 ? 13  SER   A OG  1 
ATOM   73   N  N   . ALA   A 1 14  ? -20.61074 35.01197 -29.98884 1.000 14.25565 ? 14  ALA   A N   1 
ATOM   74   C  CA  . ALA   A 1 14  ? -20.76326 33.67952 -29.42043 1.000 14.90885 ? 14  ALA   A CA  1 
ATOM   75   C  C   . ALA   A 1 14  ? -21.99589 32.95905 -29.96000 1.000 16.89052 ? 14  ALA   A C   1 
ATOM   76   O  O   . ALA   A 1 14  ? -22.02245 31.72261 -29.96663 1.000 19.21983 ? 14  ALA   A O   1 
ATOM   77   C  CB  . ALA   A 1 14  ? -20.81582 33.75974 -27.89686 1.000 11.68029 ? 14  ALA   A CB  1 
ATOM   78   N  N   . LEU   A 1 15  ? -23.01888 33.68979 -30.41452 1.000 17.94623 ? 15  LEU   A N   1 
ATOM   79   C  CA  . LEU   A 1 15  ? -24.17511 33.04209 -31.04325 1.000 20.47747 ? 15  LEU   A CA  1 
ATOM   80   C  C   . LEU   A 1 15  ? -23.85846 32.46200 -32.40971 1.000 20.86561 ? 15  LEU   A C   1 
ATOM   81   O  O   . LEU   A 1 15  ? -24.68522 31.73909 -32.96397 1.000 25.71447 ? 15  LEU   A O   1 
ATOM   82   C  CB  . LEU   A 1 15  ? -25.32077 34.04550 -31.17802 1.000 18.85900 ? 15  LEU   A CB  1 
ATOM   83   C  CG  . LEU   A 1 15  ? -25.51442 34.75144 -29.85460 1.000 20.86062 ? 15  LEU   A CG  1 
ATOM   84   C  CD1 . LEU   A 1 15  ? -26.50221 35.84203 -30.04339 1.000 32.29910 ? 15  LEU   A CD1 1 
ATOM   85   C  CD2 . LEU   A 1 15  ? -25.97264 33.71171 -28.81175 1.000 24.29706 ? 15  LEU   A CD2 1 
ATOM   86   N  N   . ASN   A 1 16  ? -22.69760 32.78037 -32.96482 1.000 24.67343 ? 16  ASN   A N   1 
ATOM   87   C  CA  . ASN   A 1 16  ? -22.21461 32.21650 -34.21522 1.000 25.70286 ? 16  ASN   A CA  1 
ATOM   88   C  C   . ASN   A 1 16  ? -21.13436 31.17521 -33.99800 1.000 28.50152 ? 16  ASN   A C   1 
ATOM   89   O  O   . ASN   A 1 16  ? -20.58016 30.66137 -34.97653 1.000 27.11546 ? 16  ASN   A O   1 
ATOM   90   C  CB  . ASN   A 1 16  ? -21.64748 33.32236 -35.11305 1.000 25.72761 ? 16  ASN   A CB  1 
ATOM   91   C  CG  . ASN   A 1 16  ? -22.72957 34.16820 -35.73901 1.000 41.86223 ? 16  ASN   A CG  1 
ATOM   92   O  OD1 . ASN   A 1 16  ? -22.49510 35.32860 -36.11575 1.000 43.84391 ? 16  ASN   A OD1 1 
ATOM   93   N  ND2 . ASN   A 1 16  ? -23.92927 33.59763 -35.85478 1.000 33.62274 ? 16  ASN   A ND2 1 
ATOM   94   N  N   . ALA   A 1 17  ? -20.77992 30.89928 -32.75371 1.000 20.24219 ? 17  ALA   A N   1 
ATOM   95   C  CA  . ALA   A 1 17  ? -19.62930 30.06490 -32.50530 1.000 17.49015 ? 17  ALA   A CA  1 
ATOM   96   C  C   . ALA   A 1 17  ? -20.04190 28.61379 -32.28845 1.000 18.08044 ? 17  ALA   A C   1 
ATOM   97   O  O   . ALA   A 1 17  ? -21.18413 28.32099 -31.91814 1.000 16.96634 ? 17  ALA   A O   1 
ATOM   98   C  CB  . ALA   A 1 17  ? -18.85362 30.58797 -31.29157 1.000 13.37029 ? 17  ALA   A CB  1 
ATOM   99   N  N   . PRO   A 1 18  ? -19.13114 27.67800 -32.54928 1.000 14.11806 ? 18  PRO   A N   1 
ATOM   100  C  CA  . PRO   A 1 18  ? -19.38756 26.27439 -32.20706 1.000 13.53517 ? 18  PRO   A CA  1 
ATOM   101  C  C   . PRO   A 1 18  ? -19.83484 26.10966 -30.75267 1.000 16.34091 ? 18  PRO   A C   1 
ATOM   102  O  O   . PRO   A 1 18  ? -19.30920 26.74817 -29.83546 1.000 13.87672 ? 18  PRO   A O   1 
ATOM   103  C  CB  . PRO   A 1 18  ? -18.03540 25.60204 -32.46846 1.000 14.55996 ? 18  PRO   A CB  1 
ATOM   104  C  CG  . PRO   A 1 18  ? -17.40145 26.43819 -33.57761 1.000 15.35997 ? 18  PRO   A CG  1 
ATOM   105  C  CD  . PRO   A 1 18  ? -17.89694 27.86179 -33.34149 1.000 14.06086 ? 18  PRO   A CD  1 
ATOM   106  N  N   . GLN   A 1 19  ? -20.79855 25.21463 -30.54997 1.000 12.15579 ? 19  GLN   A N   1 
ATOM   107  C  CA  . GLN   A 1 19  ? -21.46511 25.07713 -29.26142 1.000 12.81040 ? 19  GLN   A CA  1 
ATOM   108  C  C   . GLN   A 1 19  ? -20.55034 24.43769 -28.22405 1.000 15.14264 ? 19  GLN   A C   1 
ATOM   109  O  O   . GLN   A 1 19  ? -20.00099 23.34509 -28.43213 1.000 12.71925 ? 19  GLN   A O   1 
ATOM   110  C  CB  . GLN   A 1 19  ? -22.74020 24.25705 -29.42179 1.000 10.57994 ? 19  GLN   A CB  1 
ATOM   111  C  CG  . GLN   A 1 19  ? -23.74933 24.90039 -30.36403 1.000 15.05080 ? 19  GLN   A CG  1 
ATOM   112  C  CD  . GLN   A 1 19  ? -23.60329 24.42406 -31.80714 1.000 18.14309 ? 19  GLN   A CD  1 
ATOM   113  O  OE1 . GLN   A 1 19  ? -22.50260 24.16773 -32.27073 1.000 15.40276 ? 19  GLN   A OE1 1 
ATOM   114  N  NE2 . GLN   A 1 19  ? -24.72499 24.31086 -32.51877 1.000 19.97787 ? 19  GLN   A NE2 1 
ATOM   115  N  N   . LEU   A 1 20  ? -20.41385 25.12162 -27.08937 1.000 9.91354  ? 20  LEU   A N   1 
ATOM   116  C  CA  . LEU   A 1 20  ? -19.51219 24.66227 -26.03738 1.000 14.49631 ? 20  LEU   A CA  1 
ATOM   117  C  C   . LEU   A 1 20  ? -19.98207 23.33755 -25.43068 1.000 12.65630 ? 20  LEU   A C   1 
ATOM   118  O  O   . LEU   A 1 20  ? -19.17932 22.42503 -25.21817 1.000 13.54411 ? 20  LEU   A O   1 
ATOM   119  C  CB  . LEU   A 1 20  ? -19.38422 25.74750 -24.96702 1.000 10.51066 ? 20  LEU   A CB  1 
ATOM   120  C  CG  . LEU   A 1 20  ? -18.30721 25.55359 -23.90941 1.000 11.90480 ? 20  LEU   A CG  1 
ATOM   121  C  CD1 . LEU   A 1 20  ? -16.94652 25.33042 -24.56296 1.000 12.22481 ? 20  LEU   A CD1 1 
ATOM   122  C  CD2 . LEU   A 1 20  ? -18.27908 26.75438 -22.96377 1.000 9.59070  ? 20  LEU   A CD2 1 
ATOM   123  N  N   . ASP   A 1 21  ? -21.27895 23.20519 -25.14610 1.000 9.36241  ? 21  ASP   A N   1 
ATOM   124  C  CA  . ASP   A 1 21  ? -21.75411 21.94963 -24.56521 1.000 10.28152 ? 21  ASP   A CA  1 
ATOM   125  C  C   . ASP   A 1 21  ? -21.54558 20.76033 -25.52072 1.000 14.69975 ? 21  ASP   A C   1 
ATOM   126  O  O   . ASP   A 1 21  ? -21.24291 19.64276 -25.07800 1.000 13.48882 ? 21  ASP   A O   1 
ATOM   127  C  CB  . ASP   A 1 21  ? -23.22311 22.07971 -24.13649 1.000 11.04893 ? 21  ASP   A CB  1 
ATOM   128  C  CG  . ASP   A 1 21  ? -24.18206 22.31477 -25.31410 1.000 13.69088 ? 21  ASP   A CG  1 
ATOM   129  O  OD1 . ASP   A 1 21  ? -23.78973 22.95401 -26.31019 1.000 10.15420 ? 21  ASP   A OD1 1 
ATOM   130  O  OD2 . ASP   A 1 21  ? -25.34360 21.85106 -25.23868 1.000 14.77223 ? 21  ASP   A OD2 1 
ATOM   131  N  N   . GLN   A 1 22  ? -21.68257 20.97995 -26.82991 1.000 13.31501 ? 22  GLN   A N   1 
ATOM   132  C  CA  . GLN   A 1 22  ? -21.53607 19.87738 -27.77802 1.000 13.67593 ? 22  GLN   A CA  1 
ATOM   133  C  C   . GLN   A 1 22  ? -20.09011 19.42594 -27.89598 1.000 17.07816 ? 22  GLN   A C   1 
ATOM   134  O  O   . GLN   A 1 22  ? -19.82964 18.23415 -28.11609 1.000 16.84956 ? 22  GLN   A O   1 
ATOM   135  C  CB  . GLN   A 1 22  ? -22.09024 20.27969 -29.14256 1.000 10.83241 ? 22  GLN   A CB  1 
ATOM   136  C  CG  . GLN   A 1 22  ? -23.62269 20.30640 -29.14522 1.000 15.58383 ? 22  GLN   A CG  1 
ATOM   137  C  CD  . GLN   A 1 22  ? -24.22060 20.80316 -30.44602 1.000 18.22665 ? 22  GLN   A CD  1 
ATOM   138  O  OE1 . GLN   A 1 22  ? -23.68264 20.54378 -31.51983 1.000 24.89748 ? 22  GLN   A OE1 1 
ATOM   139  N  NE2 . GLN   A 1 22  ? -25.33574 21.53439 -30.35523 1.000 16.18760 ? 22  GLN   A NE2 1 
ATOM   140  N  N   . ARG   A 1 23  ? -19.14706 20.35554 -27.73427 1.000 13.15822 ? 23  ARG   A N   1 
ATOM   141  C  CA  . ARG   A 1 23  ? -17.73173 20.00854 -27.71954 1.000 15.55719 ? 23  ARG   A CA  1 
ATOM   142  C  C   . ARG   A 1 23  ? -17.41325 19.02337 -26.60656 1.000 14.97530 ? 23  ARG   A C   1 
ATOM   143  O  O   . ARG   A 1 23  ? -16.55421 18.14712 -26.78227 1.000 13.69467 ? 23  ARG   A O   1 
ATOM   144  C  CB  . ARG   A 1 23  ? -16.88730 21.28338 -27.57631 1.000 12.32630 ? 23  ARG   A CB  1 
ATOM   145  C  CG  . ARG   A 1 23  ? -15.42727 21.07277 -27.12578 1.000 13.14261 ? 23  ARG   A CG  1 
ATOM   146  C  CD  . ARG   A 1 23  ? -14.57184 20.30671 -28.15721 1.000 14.20538 ? 23  ARG   A CD  1 
ATOM   147  N  NE  . ARG   A 1 23  ? -13.18737 20.18320 -27.70258 1.000 15.12485 ? 23  ARG   A NE  1 
ATOM   148  C  CZ  . ARG   A 1 23  ? -12.76767 19.27790 -26.81941 1.000 15.56137 ? 23  ARG   A CZ  1 
ATOM   149  N  NH1 . ARG   A 1 23  ? -13.63145 18.41505 -26.28396 1.000 17.05111 ? 23  ARG   A NH1 1 
ATOM   150  N  NH2 . ARG   A 1 23  ? -11.49316 19.24125 -26.45242 1.000 14.40302 ? 23  ARG   A NH2 1 
ATOM   151  N  N   . TYR   A 1 24  ? -18.11661 19.12404 -25.47833 1.000 10.80841 ? 24  TYR   A N   1 
ATOM   152  C  CA  . TYR   A 1 24  ? -17.79940 18.35516 -24.28028 1.000 12.92151 ? 24  TYR   A CA  1 
ATOM   153  C  C   . TYR   A 1 24  ? -18.85865 17.31581 -23.92557 1.000 11.69796 ? 24  TYR   A C   1 
ATOM   154  O  O   . TYR   A 1 24  ? -18.76432 16.70713 -22.86370 1.000 13.85149 ? 24  TYR   A O   1 
ATOM   155  C  CB  . TYR   A 1 24  ? -17.56866 19.30485 -23.09117 1.000 12.74794 ? 24  TYR   A CB  1 
ATOM   156  C  CG  . TYR   A 1 24  ? -16.25635 20.04654 -23.20706 1.000 12.47374 ? 24  TYR   A CG  1 
ATOM   157  C  CD1 . TYR   A 1 24  ? -15.05408 19.40087 -22.92547 1.000 11.82735 ? 24  TYR   A CD1 1 
ATOM   158  C  CD2 . TYR   A 1 24  ? -16.20931 21.37472 -23.63613 1.000 11.33305 ? 24  TYR   A CD2 1 
ATOM   159  C  CE1 . TYR   A 1 24  ? -13.83491 20.04797 -23.05807 1.000 13.19350 ? 24  TYR   A CE1 1 
ATOM   160  C  CE2 . TYR   A 1 24  ? -14.98535 22.04268 -23.76579 1.000 12.81411 ? 24  TYR   A CE2 1 
ATOM   161  C  CZ  . TYR   A 1 24  ? -13.79943 21.36188 -23.48661 1.000 15.98031 ? 24  TYR   A CZ  1 
ATOM   162  O  OH  . TYR   A 1 24  ? -12.57139 21.97677 -23.61989 1.000 12.25566 ? 24  TYR   A OH  1 
ATOM   163  N  N   . LYS   A 1 25  ? -19.82495 17.04602 -24.80881 1.000 17.89227 ? 25  LYS   A N   1 
ATOM   164  C  CA  . LYS   A 1 25  ? -21.02310 16.30941 -24.39101 1.000 21.17624 ? 25  LYS   A CA  1 
ATOM   165  C  C   . LYS   A 1 25  ? -20.74668 14.87073 -23.94984 1.000 20.38893 ? 25  LYS   A C   1 
ATOM   166  O  O   . LYS   A 1 25  ? -21.57794 14.29807 -23.24464 1.000 18.83324 ? 25  LYS   A O   1 
ATOM   167  C  CB  . LYS   A 1 25  ? -22.05959 16.28991 -25.51108 1.000 22.73092 ? 25  LYS   A CB  1 
ATOM   168  C  CG  . LYS   A 1 25  ? -21.62913 15.49477 -26.74413 1.000 22.19621 ? 25  LYS   A CG  1 
ATOM   169  C  CD  . LYS   A 1 25  ? -22.81376 15.29246 -27.66396 1.000 25.96583 ? 25  LYS   A CD  1 
ATOM   170  C  CE  . LYS   A 1 25  ? -22.38561 14.90034 -29.05064 1.000 22.58640 ? 25  LYS   A CE  1 
ATOM   171  N  NZ  . LYS   A 1 25  ? -21.82572 16.05947 -29.77563 1.000 26.30221 ? 25  LYS   A NZ  1 
ATOM   172  N  N   . ASN   A 1 26  ? -19.62405 14.25983 -24.34703 1.000 15.95591 ? 26  ASN   A N   1 
ATOM   173  C  CA  . ASN   A 1 26  ? -19.28958 12.93292 -23.82832 1.000 16.69485 ? 26  ASN   A CA  1 
ATOM   174  C  C   . ASN   A 1 26  ? -18.39775 12.97424 -22.59548 1.000 16.64032 ? 26  ASN   A C   1 
ATOM   175  O  O   . ASN   A 1 26  ? -18.22530 11.94076 -21.93969 1.000 16.15807 ? 26  ASN   A O   1 
ATOM   176  C  CB  . ASN   A 1 26  ? -18.61214 12.08594 -24.91517 1.000 17.91160 ? 26  ASN   A CB  1 
ATOM   177  C  CG  . ASN   A 1 26  ? -19.48186 11.95161 -26.15098 1.000 22.29724 ? 26  ASN   A CG  1 
ATOM   178  O  OD1 . ASN   A 1 26  ? -20.69970 11.75795 -26.03794 1.000 19.46851 ? 26  ASN   A OD1 1 
ATOM   179  N  ND2 . ASN   A 1 26  ? -18.87791 12.08409 -27.33380 1.000 16.01099 ? 26  ASN   A ND2 1 
ATOM   180  N  N   . GLU   A 1 27  ? -17.84026 14.13430 -22.25569 1.000 13.88286 ? 27  GLU   A N   1 
ATOM   181  C  CA  . GLU   A 1 27  ? -16.94848 14.25343 -21.11355 1.000 14.20383 ? 27  GLU   A CA  1 
ATOM   182  C  C   . GLU   A 1 27  ? -17.67100 14.70753 -19.84155 1.000 17.43730 ? 27  GLU   A C   1 
ATOM   183  O  O   . GLU   A 1 27  ? -17.48259 14.10555 -18.77796 1.000 19.71347 ? 27  GLU   A O   1 
ATOM   184  C  CB  . GLU   A 1 27  ? -15.80492 15.21200 -21.46037 1.000 13.90940 ? 27  GLU   A CB  1 
ATOM   185  C  CG  . GLU   A 1 27  ? -15.39537 15.24021 -22.94160 1.000 14.54088 ? 27  GLU   A CG  1 
ATOM   186  C  CD  . GLU   A 1 27  ? -15.05006 13.86205 -23.49852 1.000 16.60313 ? 27  GLU   A CD  1 
ATOM   187  O  OE1 . GLU   A 1 27  ? -14.50739 13.01121 -22.76314 1.000 15.67444 ? 27  GLU   A OE1 1 
ATOM   188  O  OE2 . GLU   A 1 27  ? -15.33890 13.62095 -24.68101 1.000 14.25165 ? 27  GLU   A OE2 1 
ATOM   189  N  N   . PHE   A 1 28  ? -18.50247 15.74957 -19.93217 1.000 15.54738 ? 28  PHE   A N   1 
ATOM   190  C  CA  . PHE   A 1 28  ? -19.27153 16.29934 -18.81596 1.000 13.85571 ? 28  PHE   A CA  1 
ATOM   191  C  C   . PHE   A 1 28  ? -20.20731 17.35537 -19.38734 1.000 13.81508 ? 28  PHE   A C   1 
ATOM   192  O  O   . PHE   A 1 28  ? -19.95221 17.89999 -20.46575 1.000 12.26626 ? 28  PHE   A O   1 
ATOM   193  C  CB  . PHE   A 1 28  ? -18.36255 16.90466 -17.73430 1.000 10.14759 ? 28  PHE   A CB  1 
ATOM   194  C  CG  . PHE   A 1 28  ? -17.09628 17.52679 -18.28433 1.000 15.79512 ? 28  PHE   A CG  1 
ATOM   195  C  CD1 . PHE   A 1 28  ? -17.13801 18.73588 -18.97841 1.000 12.32724 ? 28  PHE   A CD1 1 
ATOM   196  C  CD2 . PHE   A 1 28  ? -15.86607 16.90185 -18.11316 1.000 14.11055 ? 28  PHE   A CD2 1 
ATOM   197  C  CE1 . PHE   A 1 28  ? -15.97626 19.30833 -19.49155 1.000 12.31824 ? 28  PHE   A CE1 1 
ATOM   198  C  CE2 . PHE   A 1 28  ? -14.69847 17.46293 -18.62105 1.000 13.98285 ? 28  PHE   A CE2 1 
ATOM   199  C  CZ  . PHE   A 1 28  ? -14.74756 18.67636 -19.30868 1.000 14.30220 ? 28  PHE   A CZ  1 
ATOM   200  N  N   . THR   A 1 29  ? -21.29452 17.64008 -18.66335 1.000 10.03553 ? 29  THR   A N   1 
ATOM   201  C  CA  . THR   A 1 29  ? -22.17424 18.73308 -19.06637 1.000 11.07336 ? 29  THR   A CA  1 
ATOM   202  C  C   . THR   A 1 29  ? -21.48415 20.08287 -18.84029 1.000 10.59587 ? 29  THR   A C   1 
ATOM   203  O  O   . THR   A 1 29  ? -20.51138 20.18867 -18.08888 1.000 11.48893 ? 29  THR   A O   1 
ATOM   204  C  CB  . THR   A 1 29  ? -23.49447 18.68935 -18.28680 1.000 14.48146 ? 29  THR   A CB  1 
ATOM   205  O  OG1 . THR   A 1 29  ? -23.20888 18.69836 -16.88362 1.000 11.86761 ? 29  THR   A OG1 1 
ATOM   206  C  CG2 . THR   A 1 29  ? -24.28835 17.42085 -18.61330 1.000 14.60820 ? 29  THR   A CG2 1 
ATOM   207  N  N   . ILE   A 1 30  ? -22.01083 21.12519 -19.49259 1.000 10.77994 ? 30  ILE   A N   1 
ATOM   208  C  CA  . ILE   A 1 30  ? -21.50067 22.49273 -19.39131 1.000 10.81826 ? 30  ILE   A CA  1 
ATOM   209  C  C   . ILE   A 1 30  ? -22.62738 23.38055 -18.86385 1.000 11.95508 ? 30  ILE   A C   1 
ATOM   210  O  O   . ILE   A 1 30  ? -23.67175 23.52872 -19.51533 1.000 9.95798  ? 30  ILE   A O   1 
ATOM   211  C  CB  . ILE   A 1 30  ? -20.97324 23.01735 -20.74622 1.000 11.92535 ? 30  ILE   A CB  1 
ATOM   212  C  CG1 . ILE   A 1 30  ? -19.82484 22.15468 -21.27564 1.000 11.95130 ? 30  ILE   A CG1 1 
ATOM   213  C  CG2 . ILE   A 1 30  ? -20.51421 24.48490 -20.65556 1.000 10.18297 ? 30  ILE   A CG2 1 
ATOM   214  C  CD1 . ILE   A 1 30  ? -18.57126 22.16374 -20.40777 1.000 10.84208 ? 30  ILE   A CD1 1 
ATOM   215  N  N   . GLY   A 1 31  ? -22.40757 23.99365 -17.69891 1.000 10.90892 ? 31  GLY   A N   1 
ATOM   216  C  CA  . GLY   A 1 31  ? -23.46758 24.73531 -17.03867 1.000 9.77656  ? 31  GLY   A CA  1 
ATOM   217  C  C   . GLY   A 1 31  ? -23.18013 26.20818 -16.80508 1.000 10.86285 ? 31  GLY   A C   1 
ATOM   218  O  O   . GLY   A 1 31  ? -22.02367 26.63672 -16.86369 1.000 11.20943 ? 31  GLY   A O   1 
ATOM   219  N  N   . ALA   A 1 32  ? -24.23072 26.99099 -16.54606 1.000 9.91271  ? 32  ALA   A N   1 
ATOM   220  C  CA  . ALA   A 1 32  ? -24.11357 28.39382 -16.16770 1.000 10.26372 ? 32  ALA   A CA  1 
ATOM   221  C  C   . ALA   A 1 32  ? -25.04221 28.68668 -14.99937 1.000 12.29809 ? 32  ALA   A C   1 
ATOM   222  O  O   . ALA   A 1 32  ? -26.15611 28.15263 -14.92885 1.000 10.67800 ? 32  ALA   A O   1 
ATOM   223  C  CB  . ALA   A 1 32  ? -24.45621 29.34048 -17.32644 1.000 7.99827  ? 32  ALA   A CB  1 
ATOM   224  N  N   . ALA   A 1 33  ? -24.58594 29.55743 -14.10072 1.000 10.62564 ? 33  ALA   A N   1 
ATOM   225  C  CA  . ALA   A 1 33  ? -25.41538 30.07945 -13.01734 1.000 11.69313 ? 33  ALA   A CA  1 
ATOM   226  C  C   . ALA   A 1 33  ? -26.20106 31.28554 -13.51843 1.000 11.63965 ? 33  ALA   A C   1 
ATOM   227  O  O   . ALA   A 1 33  ? -25.63950 32.15437 -14.19453 1.000 12.38578 ? 33  ALA   A O   1 
ATOM   228  C  CB  . ALA   A 1 33  ? -24.54328 30.45449 -11.81405 1.000 7.60334  ? 33  ALA   A CB  1 
ATOM   229  N  N   . VAL   A 1 34  ? -27.50405 31.33920 -13.21651 1.000 10.58419 ? 34  VAL   A N   1 
ATOM   230  C  CA  . VAL   A 1 34  ? -28.35667 32.37491 -13.79795 1.000 14.81352 ? 34  VAL   A CA  1 
ATOM   231  C  C   . VAL   A 1 34  ? -29.28555 33.01190 -12.76335 1.000 17.84365 ? 34  VAL   A C   1 
ATOM   232  O  O   . VAL   A 1 34  ? -29.55796 32.45597 -11.69632 1.000 13.85665 ? 34  VAL   A O   1 
ATOM   233  C  CB  . VAL   A 1 34  ? -29.20725 31.85301 -14.98427 1.000 12.51056 ? 34  VAL   A CB  1 
ATOM   234  C  CG1 . VAL   A 1 34  ? -28.34285 31.04821 -15.98477 1.000 8.32696  ? 34  VAL   A CG1 1 
ATOM   235  C  CG2 . VAL   A 1 34  ? -30.37675 31.03955 -14.48582 1.000 13.38546 ? 34  VAL   A CG2 1 
ATOM   236  N  N   . GLU   A 1 35  ? -29.77926 34.22211 -13.11768 1.000 13.04077 ? 35  GLU   A N   1 
ATOM   237  C  CA  . GLU   A 1 35  ? -30.83946 34.97367 -12.48307 1.000 13.81117 ? 35  GLU   A CA  1 
ATOM   238  C  C   . GLU   A 1 35  ? -32.08703 34.98165 -13.36520 1.000 14.62539 ? 35  GLU   A C   1 
ATOM   239  O  O   . GLU   A 1 35  ? -31.98349 34.99788 -14.59223 1.000 14.21055 ? 35  GLU   A O   1 
ATOM   240  C  CB  . GLU   A 1 35  ? -30.40361 36.41890 -12.21934 1.000 16.15178 ? 35  GLU   A CB  1 
ATOM   241  C  CG  . GLU   A 1 35  ? -29.19446 36.55948 -11.32052 1.000 12.04386 ? 35  GLU   A CG  1 
ATOM   242  C  CD  . GLU   A 1 35  ? -29.58187 36.52807 -9.84904  1.000 17.25924 ? 35  GLU   A CD  1 
ATOM   243  O  OE1 . GLU   A 1 35  ? -30.63943 35.96245 -9.51566  1.000 13.68504 ? 35  GLU   A OE1 1 
ATOM   244  O  OE2 . GLU   A 1 35  ? -28.82693 37.06256 -9.02312  1.000 18.43285 ? 35  GLU   A OE2 1 
ATOM   245  N  N   . PRO   A 1 36  ? -33.28329 34.97051 -12.77815 1.000 16.60707 ? 36  PRO   A N   1 
ATOM   246  C  CA  . PRO   A 1 36  ? -34.50073 34.99830 -13.61553 1.000 21.35130 ? 36  PRO   A CA  1 
ATOM   247  C  C   . PRO   A 1 36  ? -34.53234 36.10779 -14.66273 1.000 17.59336 ? 36  PRO   A C   1 
ATOM   248  O  O   . PRO   A 1 36  ? -34.94027 35.84465 -15.80181 1.000 16.71732 ? 36  PRO   A O   1 
ATOM   249  C  CB  . PRO   A 1 36  ? -35.61377 35.13766 -12.56839 1.000 21.09357 ? 36  PRO   A CB  1 
ATOM   250  C  CG  . PRO   A 1 36  ? -35.08683 34.29343 -11.43228 1.000 22.36241 ? 36  PRO   A CG  1 
ATOM   251  C  CD  . PRO   A 1 36  ? -33.58842 34.57815 -11.39027 1.000 15.59436 ? 36  PRO   A CD  1 
ATOM   252  N  N   . TYR   A 1 37  ? -34.08230 37.32562 -14.33541 1.000 16.72795 ? 37  TYR   A N   1 
ATOM   253  C  CA  . TYR   A 1 37  ? -34.14238 38.40216 -15.32455 1.000 21.41863 ? 37  TYR   A CA  1 
ATOM   254  C  C   . TYR   A 1 37  ? -33.36837 38.04383 -16.59788 1.000 20.77772 ? 37  TYR   A C   1 
ATOM   255  O  O   . TYR   A 1 37  ? -33.72640 38.49222 -17.69202 1.000 21.58462 ? 37  TYR   A O   1 
ATOM   256  C  CB  . TYR   A 1 37  ? -33.64281 39.72465 -14.71021 1.000 19.83792 ? 37  TYR   A CB  1 
ATOM   257  C  CG  . TYR   A 1 37  ? -32.12930 39.90805 -14.72515 1.000 21.61500 ? 37  TYR   A CG  1 
ATOM   258  C  CD1 . TYR   A 1 37  ? -31.45793 40.18416 -15.91568 1.000 20.32329 ? 37  TYR   A CD1 1 
ATOM   259  C  CD2 . TYR   A 1 37  ? -31.37829 39.80940 -13.55993 1.000 18.08207 ? 37  TYR   A CD2 1 
ATOM   260  C  CE1 . TYR   A 1 37  ? -30.08609 40.33148 -15.96439 1.000 31.15176 ? 37  TYR   A CE1 1 
ATOM   261  C  CE2 . TYR   A 1 37  ? -29.97849 39.97355 -13.59191 1.000 22.81733 ? 37  TYR   A CE2 1 
ATOM   262  C  CZ  . TYR   A 1 37  ? -29.34222 40.23160 -14.80715 1.000 25.38197 ? 37  TYR   A CZ  1 
ATOM   263  O  OH  . TYR   A 1 37  ? -27.96465 40.39588 -14.91507 1.000 39.82319 ? 37  TYR   A OH  1 
ATOM   264  N  N   . GLN   A 1 38  ? -32.30535 37.24722 -16.48519 1.000 18.99885 ? 38  GLN   A N   1 
ATOM   265  C  CA  . GLN   A 1 38  ? -31.57027 36.85775 -17.68518 1.000 19.54411 ? 38  GLN   A CA  1 
ATOM   266  C  C   . GLN   A 1 38  ? -32.41929 36.00778 -18.62562 1.000 18.73994 ? 38  GLN   A C   1 
ATOM   267  O  O   . GLN   A 1 38  ? -32.09859 35.89586 -19.81161 1.000 20.98900 ? 38  GLN   A O   1 
ATOM   268  C  CB  . GLN   A 1 38  ? -30.27606 36.11960 -17.29507 1.000 15.99043 ? 38  GLN   A CB  1 
ATOM   269  C  CG  . GLN   A 1 38  ? -29.23103 37.04096 -16.65410 1.000 15.09824 ? 38  GLN   A CG  1 
ATOM   270  C  CD  . GLN   A 1 38  ? -28.09826 36.29437 -15.97555 1.000 13.95225 ? 38  GLN   A CD  1 
ATOM   271  O  OE1 . GLN   A 1 38  ? -28.30835 35.26939 -15.33141 1.000 16.62215 ? 38  GLN   A OE1 1 
ATOM   272  N  NE2 . GLN   A 1 38  ? -26.89284 36.81195 -16.10667 1.000 13.66201 ? 38  GLN   A NE2 1 
ATOM   273  N  N   . LEU   A 1 39  ? -33.48994 35.39685 -18.13692 1.000 21.75684 ? 39  LEU   A N   1 
ATOM   274  C  CA  . LEU   A 1 39  ? -34.36125 34.65481 -19.04121 1.000 21.55134 ? 39  LEU   A CA  1 
ATOM   275  C  C   . LEU   A 1 39  ? -35.31315 35.56938 -19.79749 1.000 21.23526 ? 39  LEU   A C   1 
ATOM   276  O  O   . LEU   A 1 39  ? -36.06993 35.09148 -20.64636 1.000 22.54593 ? 39  LEU   A O   1 
ATOM   277  C  CB  . LEU   A 1 39  ? -35.14187 33.58949 -18.25789 1.000 20.04650 ? 39  LEU   A CB  1 
ATOM   278  C  CG  . LEU   A 1 39  ? -34.30893 32.73516 -17.29265 1.000 19.94477 ? 39  LEU   A CG  1 
ATOM   279  C  CD1 . LEU   A 1 39  ? -35.20613 31.83012 -16.44871 1.000 19.96661 ? 39  LEU   A CD1 1 
ATOM   280  C  CD2 . LEU   A 1 39  ? -33.21236 31.91018 -17.99071 1.000 12.67803 ? 39  LEU   A CD2 1 
ATOM   281  N  N   . GLN   A 1 40  ? -35.30655 36.86191 -19.47766 1.000 23.51522 ? 40  GLN   A N   1 
ATOM   282  C  CA  . GLN   A 1 40  ? -36.05346 37.89299 -20.18023 1.000 26.75548 ? 40  GLN   A CA  1 
ATOM   283  C  C   . GLN   A 1 40  ? -35.17719 38.62606 -21.17643 1.000 27.73866 ? 40  GLN   A C   1 
ATOM   284  O  O   . GLN   A 1 40  ? -35.65821 39.50804 -21.88907 1.000 29.70983 ? 40  GLN   A O   1 
ATOM   285  C  CB  . GLN   A 1 40  ? -36.63471 38.90137 -19.18231 1.000 30.85673 ? 40  GLN   A CB  1 
ATOM   286  C  CG  . GLN   A 1 40  ? -37.65984 38.34044 -18.20711 1.000 27.20134 ? 40  GLN   A CG  1 
ATOM   287  C  CD  . GLN   A 1 40  ? -38.46834 37.21491 -18.80557 1.000 41.27054 ? 40  GLN   A CD  1 
ATOM   288  O  OE1 . GLN   A 1 40  ? -38.34736 36.05818 -18.39375 1.000 49.53407 ? 40  GLN   A OE1 1 
ATOM   289  N  NE2 . GLN   A 1 40  ? -39.31042 37.54410 -19.78689 1.000 48.45464 ? 40  GLN   A NE2 1 
ATOM   290  N  N   . ASN   A 1 41  ? -33.90005 38.28846 -21.21930 1.000 22.92528 ? 41  ASN   A N   1 
ATOM   291  C  CA  . ASN   A 1 41  ? -32.89830 39.00278 -21.98860 1.000 30.72596 ? 41  ASN   A CA  1 
ATOM   292  C  C   . ASN   A 1 41  ? -32.54800 38.15202 -23.20418 1.000 27.30245 ? 41  ASN   A C   1 
ATOM   293  O  O   . ASN   A 1 41  ? -32.07189 37.02118 -23.05212 1.000 23.60628 ? 41  ASN   A O   1 
ATOM   294  C  CB  . ASN   A 1 41  ? -31.68035 39.26284 -21.10302 1.000 28.45792 ? 41  ASN   A CB  1 
ATOM   295  C  CG  . ASN   A 1 41  ? -30.61245 40.02994 -21.80229 1.000 38.97497 ? 41  ASN   A CG  1 
ATOM   296  O  OD1 . ASN   A 1 41  ? -30.08364 39.59896 -22.83222 1.000 37.78162 ? 41  ASN   A OD1 1 
ATOM   297  N  ND2 . ASN   A 1 41  ? -30.26259 41.18177 -21.24156 1.000 52.68024 ? 41  ASN   A ND2 1 
ATOM   298  N  N   . GLU   A 1 42  ? -32.77576 38.69509 -24.40458 1.000 27.47623 ? 42  GLU   A N   1 
ATOM   299  C  CA  . GLU   A 1 42  ? -32.67287 37.87671 -25.61090 1.000 26.43819 ? 42  GLU   A CA  1 
ATOM   300  C  C   . GLU   A 1 42  ? -31.28420 37.26082 -25.77146 1.000 25.12521 ? 42  GLU   A C   1 
ATOM   301  O  O   . GLU   A 1 42  ? -31.16642 36.07720 -26.10628 1.000 23.82598 ? 42  GLU   A O   1 
ATOM   302  C  CB  . GLU   A 1 42  ? -33.02773 38.69290 -26.84675 1.000 26.17913 ? 42  GLU   A CB  1 
ATOM   303  C  CG  . GLU   A 1 42  ? -33.10678 37.83913 -28.10239 1.000 40.74407 ? 42  GLU   A CG  1 
ATOM   304  C  CD  . GLU   A 1 42  ? -33.39166 38.64833 -29.36079 1.000 55.88509 ? 42  GLU   A CD  1 
ATOM   305  O  OE1 . GLU   A 1 42  ? -34.16906 38.16345 -30.21572 1.000 61.78161 ? 42  GLU   A OE1 1 
ATOM   306  O  OE2 . GLU   A 1 42  ? -32.83825 39.76487 -29.49746 1.000 57.43464 ? 42  GLU   A OE2 1 
ATOM   307  N  N   . LYS   A 1 43  ? -30.22200 38.04684 -25.55953 1.000 19.92504 ? 43  LYS   A N   1 
ATOM   308  C  CA  . LYS   A 1 43  ? -28.87545 37.51648 -25.75313 1.000 22.51549 ? 43  LYS   A CA  1 
ATOM   309  C  C   . LYS   A 1 43  ? -28.56878 36.41146 -24.75062 1.000 18.92774 ? 43  LYS   A C   1 
ATOM   310  O  O   . LYS   A 1 43  ? -28.04157 35.35902 -25.12951 1.000 14.36411 ? 43  LYS   A O   1 
ATOM   311  C  CB  . LYS   A 1 43  ? -27.82816 38.63011 -25.65390 1.000 23.63560 ? 43  LYS   A CB  1 
ATOM   312  C  CG  . LYS   A 1 43  ? -28.04033 39.81155 -26.60486 1.000 28.51578 ? 43  LYS   A CG  1 
ATOM   313  C  CD  . LYS   A 1 43  ? -26.89127 39.96037 -27.60336 1.000 36.01023 ? 43  LYS   A CD  1 
ATOM   314  C  CE  . LYS   A 1 43  ? -26.93026 38.87717 -28.64860 1.000 42.57322 ? 43  LYS   A CE  1 
ATOM   315  N  NZ  . LYS   A 1 43  ? -26.12811 39.18862 -29.87915 1.000 41.43975 ? 43  LYS   A NZ  1 
ATOM   316  N  N   . ASP   A 1 44  ? -28.91020 36.61967 -23.47204 1.000 16.44727 ? 44  ASP   A N   1 
ATOM   317  C  CA  . ASP   A 1 44  ? -28.67617 35.57987 -22.47059 1.000 16.86184 ? 44  ASP   A CA  1 
ATOM   318  C  C   . ASP   A 1 44  ? -29.44059 34.31015 -22.81215 1.000 15.95744 ? 44  ASP   A C   1 
ATOM   319  O  O   . ASP   A 1 44  ? -28.89628 33.20386 -22.71273 1.000 15.20619 ? 44  ASP   A O   1 
ATOM   320  C  CB  . ASP   A 1 44  ? -29.06428 36.07413 -21.07631 1.000 17.40752 ? 44  ASP   A CB  1 
ATOM   321  C  CG  . ASP   A 1 44  ? -28.06862 37.06071 -20.51347 1.000 18.33786 ? 44  ASP   A CG  1 
ATOM   322  O  OD1 . ASP   A 1 44  ? -26.86969 36.97074 -20.86132 1.000 14.05680 ? 44  ASP   A OD1 1 
ATOM   323  O  OD2 . ASP   A 1 44  ? -28.48499 37.93037 -19.71626 1.000 17.82064 ? 44  ASP   A OD2 1 
ATOM   324  N  N   . VAL   A 1 45  ? -30.69697 34.45112 -23.23817 1.000 14.05090 ? 45  VAL   A N   1 
ATOM   325  C  CA  . VAL   A 1 45  ? -31.48282 33.28510 -23.62074 1.000 17.43208 ? 45  VAL   A CA  1 
ATOM   326  C  C   . VAL   A 1 45  ? -30.80956 32.55491 -24.77787 1.000 18.25621 ? 45  VAL   A C   1 
ATOM   327  O  O   . VAL   A 1 45  ? -30.67407 31.32434 -24.76001 1.000 15.01986 ? 45  VAL   A O   1 
ATOM   328  C  CB  . VAL   A 1 45  ? -32.92694 33.70494 -23.96497 1.000 20.63845 ? 45  VAL   A CB  1 
ATOM   329  C  CG1 . VAL   A 1 45  ? -33.66049 32.59228 -24.72995 1.000 11.49881 ? 45  VAL   A CG1 1 
ATOM   330  C  CG2 . VAL   A 1 45  ? -33.69113 34.11954 -22.68770 1.000 16.39447 ? 45  VAL   A CG2 1 
ATOM   331  N  N   . GLN   A 1 46  ? -30.34444 33.30572 -25.78251 1.000 17.14032 ? 46  GLN   A N   1 
ATOM   332  C  CA  . GLN   A 1 46  ? -29.67258 32.68918 -26.92459 1.000 20.84575 ? 46  GLN   A CA  1 
ATOM   333  C  C   . GLN   A 1 46  ? -28.38562 31.99118 -26.48960 1.000 15.10678 ? 46  GLN   A C   1 
ATOM   334  O  O   . GLN   A 1 46  ? -28.06241 30.90004 -26.97869 1.000 13.71624 ? 46  GLN   A O   1 
ATOM   335  C  CB  . GLN   A 1 46  ? -29.38354 33.74711 -28.00370 1.000 19.13078 ? 46  GLN   A CB  1 
ATOM   336  C  CG  . GLN   A 1 46  ? -30.62094 34.30554 -28.71526 1.000 27.69078 ? 46  GLN   A CG  1 
ATOM   337  C  CD  . GLN   A 1 46  ? -30.33151 35.52633 -29.61716 1.000 41.48838 ? 46  GLN   A CD  1 
ATOM   338  O  OE1 . GLN   A 1 46  ? -29.74352 36.52332 -29.17781 1.000 39.60180 ? 46  GLN   A OE1 1 
ATOM   339  N  NE2 . GLN   A 1 46  ? -30.76738 35.45140 -30.87578 1.000 38.90702 ? 46  GLN   A NE2 1 
ATOM   340  N  N   . MET   A 1 47  ? -27.64690 32.59819 -25.55980 1.000 11.74600 ? 47  MET   A N   1 
ATOM   341  C  CA  . MET   A 1 47  ? -26.43787 31.96018 -25.04844 1.000 13.26154 ? 47  MET   A CA  1 
ATOM   342  C  C   . MET   A 1 47  ? -26.75307 30.64504 -24.34849 1.000 13.61340 ? 47  MET   A C   1 
ATOM   343  O  O   . MET   A 1 47  ? -26.04973 29.64356 -24.54422 1.000 11.15149 ? 47  MET   A O   1 
ATOM   344  C  CB  . MET   A 1 47  ? -25.71743 32.90682 -24.09101 1.000 10.73767 ? 47  MET   A CB  1 
ATOM   345  C  CG  . MET   A 1 47  ? -25.12015 34.10144 -24.78924 1.000 10.65228 ? 47  MET   A CG  1 
ATOM   346  S  SD  . MET   A 1 47  ? -23.67806 33.66704 -25.76353 1.000 14.00579 ? 47  MET   A SD  1 
ATOM   347  C  CE  . MET   A 1 47  ? -22.50570 33.23451 -24.47533 1.000 8.72600  ? 47  MET   A CE  1 
ATOM   348  N  N   . LEU   A 1 48  ? -27.79943 30.63098 -23.50785 1.000 12.58815 ? 48  LEU   A N   1 
ATOM   349  C  CA  . LEU   A 1 48  ? -28.13147 29.40716 -22.78334 1.000 11.30290 ? 48  LEU   A CA  1 
ATOM   350  C  C   . LEU   A 1 48  ? -28.58747 28.30719 -23.74361 1.000 11.31531 ? 48  LEU   A C   1 
ATOM   351  O  O   . LEU   A 1 48  ? -28.16195 27.15564 -23.61933 1.000 10.35416 ? 48  LEU   A O   1 
ATOM   352  C  CB  . LEU   A 1 48  ? -29.19704 29.70422 -21.71291 1.000 12.09122 ? 48  LEU   A CB  1 
ATOM   353  C  CG  . LEU   A 1 48  ? -28.76054 30.64551 -20.56643 1.000 14.13971 ? 48  LEU   A CG  1 
ATOM   354  C  CD1 . LEU   A 1 48  ? -29.92588 31.19466 -19.74619 1.000 9.37200  ? 48  LEU   A CD1 1 
ATOM   355  C  CD2 . LEU   A 1 48  ? -27.72182 29.99311 -19.63654 1.000 8.26096  ? 48  LEU   A CD2 1 
ATOM   356  N  N   . LYS   A 1 49  ? -29.42695 28.64601 -24.72623 1.000 11.35638 ? 49  LYS   A N   1 
ATOM   357  C  CA  . LYS   A 1 49  ? -29.85925 27.64296 -25.69921 1.000 15.80011 ? 49  LYS   A CA  1 
ATOM   358  C  C   . LYS   A 1 49  ? -28.69086 27.11477 -26.51347 1.000 14.38604 ? 49  LYS   A C   1 
ATOM   359  O  O   . LYS   A 1 49  ? -28.63917 25.91836 -26.82847 1.000 13.92296 ? 49  LYS   A O   1 
ATOM   360  C  CB  . LYS   A 1 49  ? -30.91631 28.21456 -26.64137 1.000 13.84287 ? 49  LYS   A CB  1 
ATOM   361  C  CG  . LYS   A 1 49  ? -32.24637 28.46405 -25.98061 1.000 17.38054 ? 49  LYS   A CG  1 
ATOM   362  C  CD  . LYS   A 1 49  ? -33.26653 29.06074 -26.94000 1.000 20.36981 ? 49  LYS   A CD  1 
ATOM   363  C  CE  . LYS   A 1 49  ? -34.63141 29.18246 -26.24948 1.000 19.99163 ? 49  LYS   A CE  1 
ATOM   364  N  NZ  . LYS   A 1 49  ? -35.62007 29.97570 -27.01884 1.000 34.75520 ? 49  LYS   A NZ  1 
ATOM   365  N  N   . ARG   A 1 50  ? -27.73790 27.98776 -26.85531 1.000 11.67270 ? 50  ARG   A N   1 
ATOM   366  C  CA  . ARG   A 1 50  ? -26.68220 27.60367 -27.78696 1.000 13.65523 ? 50  ARG   A CA  1 
ATOM   367  C  C   . ARG   A 1 50  ? -25.54719 26.84315 -27.11193 1.000 13.60032 ? 50  ARG   A C   1 
ATOM   368  O  O   . ARG   A 1 50  ? -25.03662 25.87349 -27.68086 1.000 12.49726 ? 50  ARG   A O   1 
ATOM   369  C  CB  . ARG   A 1 50  ? -26.10656 28.82987 -28.50315 1.000 13.34732 ? 50  ARG   A CB  1 
ATOM   370  C  CG  . ARG   A 1 50  ? -24.97751 28.43513 -29.46437 1.000 17.19323 ? 50  ARG   A CG  1 
ATOM   371  C  CD  . ARG   A 1 50  ? -24.77226 29.42969 -30.58640 1.000 20.22301 ? 50  ARG   A CD  1 
ATOM   372  N  NE  . ARG   A 1 50  ? -23.86122 28.93840 -31.62123 1.000 21.90177 ? 50  ARG   A NE  1 
ATOM   373  C  CZ  . ARG   A 1 50  ? -24.24443 28.25369 -32.69519 1.000 23.16751 ? 50  ARG   A CZ  1 
ATOM   374  N  NH1 . ARG   A 1 50  ? -25.52170 27.96059 -32.87778 1.000 20.42768 ? 50  ARG   A NH1 1 
ATOM   375  N  NH2 . ARG   A 1 50  ? -23.34593 27.85916 -33.58842 1.000 17.38607 ? 50  ARG   A NH2 1 
ATOM   376  N  N   . HIS   A 1 51  ? -25.12284 27.24756 -25.91368 1.000 11.61711 ? 51  HIS   A N   1 
ATOM   377  C  CA  . HIS   A 1 51  ? -23.84499 26.75341 -25.41029 1.000 10.80304 ? 51  HIS   A CA  1 
ATOM   378  C  C   . HIS   A 1 51  ? -23.91682 25.87058 -24.17066 1.000 11.80655 ? 51  HIS   A C   1 
ATOM   379  O  O   . HIS   A 1 51  ? -22.92070 25.20657 -23.86147 1.000 12.93823 ? 51  HIS   A O   1 
ATOM   380  C  CB  . HIS   A 1 51  ? -22.89922 27.92838 -25.11883 1.000 10.53869 ? 51  HIS   A CB  1 
ATOM   381  C  CG  . HIS   A 1 51  ? -22.34023 28.57035 -26.35435 1.000 11.98436 ? 51  HIS   A CG  1 
ATOM   382  N  ND1 . HIS   A 1 51  ? -21.39532 27.95650 -27.15110 1.000 12.53286 ? 51  HIS   A ND1 1 
ATOM   383  C  CD2 . HIS   A 1 51  ? -22.58850 29.77424 -26.92479 1.000 9.81497  ? 51  HIS   A CD2 1 
ATOM   384  C  CE1 . HIS   A 1 51  ? -21.09409 28.75136 -28.16319 1.000 14.16783 ? 51  HIS   A CE1 1 
ATOM   385  N  NE2 . HIS   A 1 51  ? -21.80374 29.85894 -28.04982 1.000 14.41382 ? 51  HIS   A NE2 1 
ATOM   386  N  N   . PHE   A 1 52  ? -25.03592 25.83246 -23.45675 1.000 11.25887 ? 52  PHE   A N   1 
ATOM   387  C  CA  . PHE   A 1 52  ? -25.09305 25.18308 -22.15891 1.000 9.90252  ? 52  PHE   A CA  1 
ATOM   388  C  C   . PHE   A 1 52  ? -26.16809 24.10711 -22.14697 1.000 14.12262 ? 52  PHE   A C   1 
ATOM   389  O  O   . PHE   A 1 52  ? -27.20227 24.22258 -22.82216 1.000 13.58082 ? 52  PHE   A O   1 
ATOM   390  C  CB  . PHE   A 1 52  ? -25.36440 26.20848 -21.04236 1.000 10.88164 ? 52  PHE   A CB  1 
ATOM   391  C  CG  . PHE   A 1 52  ? -24.30006 27.26854 -20.92497 1.000 11.23590 ? 52  PHE   A CG  1 
ATOM   392  C  CD1 . PHE   A 1 52  ? -24.38917 28.44871 -21.65933 1.000 10.60844 ? 52  PHE   A CD1 1 
ATOM   393  C  CD2 . PHE   A 1 52  ? -23.21206 27.08456 -20.08101 1.000 9.82516  ? 52  PHE   A CD2 1 
ATOM   394  C  CE1 . PHE   A 1 52  ? -23.40395 29.42418 -21.56140 1.000 13.87405 ? 52  PHE   A CE1 1 
ATOM   395  C  CE2 . PHE   A 1 52  ? -22.22092 28.05592 -19.97279 1.000 7.91618  ? 52  PHE   A CE2 1 
ATOM   396  C  CZ  . PHE   A 1 52  ? -22.31432 29.22428 -20.70963 1.000 12.44225 ? 52  PHE   A CZ  1 
ATOM   397  N  N   . ASN   A 1 53  ? -25.93026 23.05359 -21.35633 1.000 12.38578 ? 53  ASN   A N   1 
ATOM   398  C  CA  . ASN   A 1 53  ? -26.93542 22.00267 -21.20943 1.000 13.34474 ? 53  ASN   A CA  1 
ATOM   399  C  C   . ASN   A 1 53  ? -27.17447 21.66756 -19.74509 1.000 14.33508 ? 53  ASN   A C   1 
ATOM   400  O  O   . ASN   A 1 53  ? -27.72910 20.61027 -19.43560 1.000 15.82457 ? 53  ASN   A O   1 
ATOM   401  C  CB  . ASN   A 1 53  ? -26.55393 20.73689 -21.99201 1.000 11.48883 ? 53  ASN   A CB  1 
ATOM   402  C  CG  . ASN   A 1 53  ? -25.18260 20.20194 -21.62605 1.000 13.11106 ? 53  ASN   A CG  1 
ATOM   403  O  OD1 . ASN   A 1 53  ? -24.55700 20.65966 -20.67351 1.000 14.75065 ? 53  ASN   A OD1 1 
ATOM   404  N  ND2 . ASN   A 1 53  ? -24.71053 19.21448 -22.38254 1.000 13.91326 ? 53  ASN   A ND2 1 
ATOM   405  N  N   . SER   A 1 54  ? -26.74497 22.54609 -18.84736 1.000 12.99328 ? 54  SER   A N   1 
ATOM   406  C  CA  . SER   A 1 54  ? -26.95721 22.41785 -17.41983 1.000 9.29180  ? 54  SER   A CA  1 
ATOM   407  C  C   . SER   A 1 54  ? -27.11970 23.83018 -16.88339 1.000 13.39292 ? 54  SER   A C   1 
ATOM   408  O  O   . SER   A 1 54  ? -26.57450 24.77935 -17.45796 1.000 12.55524 ? 54  SER   A O   1 
ATOM   409  C  CB  . SER   A 1 54  ? -25.79255 21.68698 -16.74258 1.000 12.66738 ? 54  SER   A CB  1 
ATOM   410  O  OG  . SER   A 1 54  ? -26.02168 21.54219 -15.34603 1.000 15.67277 ? 54  SER   A OG  1 
ATOM   411  N  N   . ILE   A 1 55  ? -27.87717 23.96836 -15.79049 1.000 11.24325 ? 55  ILE   A N   1 
ATOM   412  C  CA  . ILE   A 1 55  ? -28.22504 25.27397 -15.23346 1.000 10.44873 ? 55  ILE   A CA  1 
ATOM   413  C  C   . ILE   A 1 55  ? -28.31098 25.17297 -13.70704 1.000 12.77616 ? 55  ILE   A C   1 
ATOM   414  O  O   . ILE   A 1 55  ? -28.57687 24.10363 -13.14363 1.000 13.08447 ? 55  ILE   A O   1 
ATOM   415  C  CB  . ILE   A 1 55  ? -29.55589 25.80688 -15.83595 1.000 13.57432 ? 55  ILE   A CB  1 
ATOM   416  C  CG1 . ILE   A 1 55  ? -29.61634 27.33281 -15.74662 1.000 14.11172 ? 55  ILE   A CG1 1 
ATOM   417  C  CG2 . ILE   A 1 55  ? -30.78277 25.18330 -15.12880 1.000 9.93345  ? 55  ILE   A CG2 1 
ATOM   418  C  CD1 . ILE   A 1 55  ? -30.71786 27.98012 -16.58221 1.000 13.92662 ? 55  ILE   A CD1 1 
ATOM   419  N  N   . VAL   A 1 56  ? -28.07586 26.30866 -13.04461 1.000 10.10882 ? 56  VAL   A N   1 
ATOM   420  C  CA  . VAL   A 1 56  ? -28.15043 26.45531 -11.59317 1.000 11.54470 ? 56  VAL   A CA  1 
ATOM   421  C  C   . VAL   A 1 56  ? -28.57602 27.89525 -11.30128 1.000 11.89342 ? 56  VAL   A C   1 
ATOM   422  O  O   . VAL   A 1 56  ? -28.25184 28.81879 -12.05110 1.000 13.77004 ? 56  VAL   A O   1 
ATOM   423  C  CB  . VAL   A 1 56  ? -26.78807 26.11697 -10.91921 1.000 11.62819 ? 56  VAL   A CB  1 
ATOM   424  C  CG1 . VAL   A 1 56  ? -25.70119 27.08137 -11.37971 1.000 11.46072 ? 56  VAL   A CG1 1 
ATOM   425  C  CG2 . VAL   A 1 56  ? -26.87380 26.12485 -9.42016  1.000 9.61646  ? 56  VAL   A CG2 1 
ATOM   426  N  N   . ALA   A 1 57  ? -29.30983 28.09007 -10.21008 1.000 10.04306 ? 57  ALA   A N   1 
ATOM   427  C  CA  . ALA   A 1 57  ? -29.70263 29.43520 -9.79978  1.000 12.53414 ? 57  ALA   A CA  1 
ATOM   428  C  C   . ALA   A 1 57  ? -28.56985 30.12012 -9.03822  1.000 12.88146 ? 57  ALA   A C   1 
ATOM   429  O  O   . ALA   A 1 57  ? -28.06073 29.58554 -8.04441  1.000 12.98836 ? 57  ALA   A O   1 
ATOM   430  C  CB  . ALA   A 1 57  ? -30.96292 29.38707 -8.92931  1.000 11.87061 ? 57  ALA   A CB  1 
ATOM   431  N  N   . GLU   A 1 58  ? -28.18577 31.31009 -9.50516  1.000 10.53625 ? 58  GLU   A N   1 
ATOM   432  C  CA  . GLU   A 1 58  ? -27.17913 32.09725 -8.80452  1.000 13.56573 ? 58  GLU   A CA  1 
ATOM   433  C  C   . GLU   A 1 58  ? -27.64235 32.48128 -7.39390  1.000 16.87572 ? 58  GLU   A C   1 
ATOM   434  O  O   . GLU   A 1 58  ? -26.82902 32.52943 -6.45822  1.000 16.61441 ? 58  GLU   A O   1 
ATOM   435  C  CB  . GLU   A 1 58  ? -26.82825 33.34648 -9.63134  1.000 13.18952 ? 58  GLU   A CB  1 
ATOM   436  C  CG  . GLU   A 1 58  ? -25.51473 34.02995 -9.20717  1.000 16.57929 ? 58  GLU   A CG  1 
ATOM   437  C  CD  . GLU   A 1 58  ? -25.25599 35.42522 -9.82035  1.000 16.41020 ? 58  GLU   A CD  1 
ATOM   438  O  OE1 . GLU   A 1 58  ? -24.34191 36.13533 -9.33943  1.000 22.16588 ? 58  GLU   A OE1 1 
ATOM   439  O  OE2 . GLU   A 1 58  ? -25.94865 35.85351 -10.75740 1.000 20.37850 ? 58  GLU   A OE2 1 
ATOM   440  N  N   . ASN   A 1 59  ? -28.94937 32.75496 -7.21322  1.000 12.16049 ? 59  ASN   A N   1 
ATOM   441  C  CA  . ASN   A 1 59  ? -29.42262 33.27330 -5.92911  1.000 12.65629 ? 59  ASN   A CA  1 
ATOM   442  C  C   . ASN   A 1 59  ? -30.81002 32.79968 -5.51188  1.000 15.41304 ? 59  ASN   A C   1 
ATOM   443  O  O   . ASN   A 1 59  ? -31.03660 32.63959 -4.30739  1.000 14.66040 ? 59  ASN   A O   1 
ATOM   444  C  CB  . ASN   A 1 59  ? -29.43764 34.80271 -5.94443  1.000 9.63810  ? 59  ASN   A CB  1 
ATOM   445  C  CG  . ASN   A 1 59  ? -28.07991 35.40586 -5.69109  1.000 13.28813 ? 59  ASN   A CG  1 
ATOM   446  O  OD1 . ASN   A 1 59  ? -27.43878 35.14021 -4.67174  1.000 12.79264 ? 59  ASN   A OD1 1 
ATOM   447  N  ND2 . ASN   A 1 59  ? -27.62858 36.22608 -6.62559  1.000 12.36301 ? 59  ASN   A ND2 1 
ATOM   448  N  N   . VAL   A 1 60  ? -31.76102 32.59392 -6.43212  1.000 12.47782 ? 60  VAL   A N   1 
ATOM   449  C  CA  . VAL   A 1 60  ? -33.15692 32.48581 -6.01293  1.000 12.90527 ? 60  VAL   A CA  1 
ATOM   450  C  C   . VAL   A 1 60  ? -33.52579 31.13828 -5.41655  1.000 14.83402 ? 60  VAL   A C   1 
ATOM   451  O  O   . VAL   A 1 60  ? -34.68517 30.96018 -5.02319  1.000 11.39162 ? 60  VAL   A O   1 
ATOM   452  C  CB  . VAL   A 1 60  ? -34.12435 32.79598 -7.17218  1.000 15.61971 ? 60  VAL   A CB  1 
ATOM   453  C  CG1 . VAL   A 1 60  ? -33.95027 34.24233 -7.62490  1.000 12.10261 ? 60  VAL   A CG1 1 
ATOM   454  C  CG2 . VAL   A 1 60  ? -33.93885 31.81125 -8.31975  1.000 10.82574 ? 60  VAL   A CG2 1 
ATOM   455  N  N   . MET   A 1 61  ? -32.59102 30.18581 -5.31096  1.000 12.21525 ? 61  MET   A N   1 
ATOM   456  C  CA  . MET   A 1 61  ? -32.87640 28.93316 -4.61592  1.000 13.14709 ? 61  MET   A CA  1 
ATOM   457  C  C   . MET   A 1 61  ? -32.14009 28.81587 -3.28501  1.000 14.93289 ? 61  MET   A C   1 
ATOM   458  O  O   . MET   A 1 61  ? -32.16735 27.74450 -2.66607  1.000 13.58136 ? 61  MET   A O   1 
ATOM   459  C  CB  . MET   A 1 61  ? -32.56724 27.73266 -5.51368  1.000 10.87784 ? 61  MET   A CB  1 
ATOM   460  C  CG  . MET   A 1 61  ? -33.53701 27.63218 -6.70335  1.000 13.36528 ? 61  MET   A CG  1 
ATOM   461  S  SD  . MET   A 1 61  ? -33.34646 26.12093 -7.67455  1.000 13.18918 ? 61  MET   A SD  1 
ATOM   462  C  CE  . MET   A 1 61  ? -33.97135 26.63726 -9.27913  1.000 13.18997 ? 61  MET   A CE  1 
ATOM   463  N  N   . LYS   A 1 62  ? -31.50631 29.89637 -2.82113  1.000 11.76525 ? 62  LYS   A N   1 
ATOM   464  C  CA  . LYS   A 1 62  ? -30.86682 29.90520 -1.51303  1.000 16.36236 ? 62  LYS   A CA  1 
ATOM   465  C  C   . LYS   A 1 62  ? -31.91939 29.95580 -0.39926  1.000 12.97940 ? 62  LYS   A C   1 
ATOM   466  O  O   . LYS   A 1 62  ? -33.06696 30.32861 -0.63757  1.000 15.18980 ? 62  LYS   A O   1 
ATOM   467  C  CB  . LYS   A 1 62  ? -29.90244 31.08972 -1.40998  1.000 13.44660 ? 62  LYS   A CB  1 
ATOM   468  C  CG  . LYS   A 1 62  ? -28.55657 30.83663 -2.08920  1.000 12.99817 ? 62  LYS   A CG  1 
ATOM   469  C  CD  . LYS   A 1 62  ? -27.83489 32.13616 -2.43938  1.000 13.20717 ? 62  LYS   A CD  1 
ATOM   470  C  CE  . LYS   A 1 62  ? -26.60891 31.85057 -3.30654  1.000 12.81033 ? 62  LYS   A CE  1 
ATOM   471  N  NZ  . LYS   A 1 62  ? -25.81025 33.05653 -3.64757  1.000 13.07853 ? 62  LYS   A NZ  1 
ATOM   472  N  N   . PRO   A 1 63  ? -31.54785 29.56625 0.82570   1.000 14.84456 ? 63  PRO   A N   1 
ATOM   473  C  CA  . PRO   A 1 63  ? -32.55062 29.48454 1.90063   1.000 14.01388 ? 63  PRO   A CA  1 
ATOM   474  C  C   . PRO   A 1 63  ? -33.33579 30.76257 2.14220   1.000 13.36373 ? 63  PRO   A C   1 
ATOM   475  O  O   . PRO   A 1 63  ? -34.55329 30.68721 2.32637   1.000 15.14917 ? 63  PRO   A O   1 
ATOM   476  C  CB  . PRO   A 1 63  ? -31.70812 29.10267 3.12155   1.000 13.13720 ? 63  PRO   A CB  1 
ATOM   477  C  CG  . PRO   A 1 63  ? -30.58816 28.30733 2.54721   1.000 12.78172 ? 63  PRO   A CG  1 
ATOM   478  C  CD  . PRO   A 1 63  ? -30.25425 28.99573 1.24677   1.000 15.92670 ? 63  PRO   A CD  1 
ATOM   479  N  N   . ILE   A 1 64  ? -32.68836 31.93025 2.15922   1.000 17.49687 ? 64  ILE   A N   1 
ATOM   480  C  CA  . ILE   A 1 64  ? -33.42927 33.16046 2.42712   1.000 16.57291 ? 64  ILE   A CA  1 
ATOM   481  C  C   . ILE   A 1 64  ? -34.35124 33.50839 1.25987   1.000 18.47288 ? 64  ILE   A C   1 
ATOM   482  O  O   . ILE   A 1 64  ? -35.38213 34.16871 1.45676   1.000 15.85568 ? 64  ILE   A O   1 
ATOM   483  C  CB  . ILE   A 1 64  ? -32.47343 34.32737 2.76283   1.000 17.46520 ? 64  ILE   A CB  1 
ATOM   484  C  CG1 . ILE   A 1 64  ? -33.24326 35.46167 3.46132   1.000 18.30706 ? 64  ILE   A CG1 1 
ATOM   485  C  CG2 . ILE   A 1 64  ? -31.76778 34.85757 1.49621   1.000 15.22847 ? 64  ILE   A CG2 1 
ATOM   486  C  CD1 . ILE   A 1 64  ? -32.37670 36.51401 4.16288   1.000 15.79916 ? 64  ILE   A CD1 1 
ATOM   487  N  N   . SER   A 1 65  ? -34.01479 33.07403 0.03388   1.000 16.45283 ? 65  SER   A N   1 
ATOM   488  C  CA  . SER   A 1 65  ? -34.88742 33.34484 -1.10563  1.000 16.92526 ? 65  SER   A CA  1 
ATOM   489  C  C   . SER   A 1 65  ? -36.11923 32.43900 -1.10258  1.000 19.03011 ? 65  SER   A C   1 
ATOM   490  O  O   . SER   A 1 65  ? -37.19739 32.86732 -1.53100  1.000 18.87342 ? 65  SER   A O   1 
ATOM   491  C  CB  . SER   A 1 65  ? -34.12545 33.18343 -2.43257  1.000 14.57997 ? 65  SER   A CB  1 
ATOM   492  O  OG  . SER   A 1 65  ? -32.93101 33.96472 -2.45274  1.000 22.24946 ? 65  SER   A OG  1 
ATOM   493  N  N   . ILE   A 1 66  ? -35.98874 31.20289 -0.62425  1.000 17.60613 ? 66  ILE   A N   1 
ATOM   494  C  CA  . ILE   A 1 66  ? -37.09151 30.24447 -0.67740  1.000 14.75530 ? 66  ILE   A CA  1 
ATOM   495  C  C   . ILE   A 1 66  ? -38.03016 30.39666 0.51991   1.000 16.49590 ? 66  ILE   A C   1 
ATOM   496  O  O   . ILE   A 1 66  ? -39.25295 30.40133 0.35824   1.000 15.44420 ? 66  ILE   A O   1 
ATOM   497  C  CB  . ILE   A 1 66  ? -36.54155 28.80653 -0.78047  1.000 15.56993 ? 66  ILE   A CB  1 
ATOM   498  C  CG1 . ILE   A 1 66  ? -35.76339 28.61375 -2.08938  1.000 14.25366 ? 66  ILE   A CG1 1 
ATOM   499  C  CG2 . ILE   A 1 66  ? -37.68142 27.78511 -0.65957  1.000 12.49721 ? 66  ILE   A CG2 1 
ATOM   500  C  CD1 . ILE   A 1 66  ? -36.64051 28.42452 -3.31588  1.000 11.36275 ? 66  ILE   A CD1 1 
ATOM   501  N  N   . GLN   A 1 67  ? -37.51138 30.51732 1.74566   1.000 13.59975 ? 67  GLN   A N   1 
ATOM   502  C  CA  . GLN   A 1 67  ? -38.36154 30.66127 2.93413   1.000 18.80979 ? 67  GLN   A CA  1 
ATOM   503  C  C   . GLN   A 1 67  ? -37.89897 31.82526 3.81475   1.000 15.63364 ? 67  GLN   A C   1 
ATOM   504  O  O   . GLN   A 1 67  ? -37.33861 31.62402 4.90074   1.000 16.76000 ? 67  GLN   A O   1 
ATOM   505  C  CB  . GLN   A 1 67  ? -38.40528 29.35700 3.73092   1.000 15.49730 ? 67  GLN   A CB  1 
ATOM   506  C  CG  . GLN   A 1 67  ? -39.67373 29.25630 4.60855   1.000 16.48620 ? 67  GLN   A CG  1 
ATOM   507  C  CD  . GLN   A 1 67  ? -39.69331 28.04743 5.53770   1.000 14.31614 ? 67  GLN   A CD  1 
ATOM   508  O  OE1 . GLN   A 1 67  ? -40.63401 27.86084 6.30694   1.000 17.54289 ? 67  GLN   A OE1 1 
ATOM   509  N  NE2 . GLN   A 1 67  ? -38.67264 27.21397 5.45025   1.000 13.51587 ? 67  GLN   A NE2 1 
ATOM   510  N  N   . PRO   A 1 68  ? -38.12732 33.06584 3.37749   1.000 15.77536 ? 68  PRO   A N   1 
ATOM   511  C  CA  . PRO   A 1 68  ? -37.60954 34.21307 4.14196   1.000 17.94706 ? 68  PRO   A CA  1 
ATOM   512  C  C   . PRO   A 1 68  ? -38.29924 34.41907 5.48019   1.000 18.68586 ? 68  PRO   A C   1 
ATOM   513  O  O   . PRO   A 1 68  ? -37.70207 35.03959 6.37053   1.000 21.14658 ? 68  PRO   A O   1 
ATOM   514  C  CB  . PRO   A 1 68  ? -37.84919 35.39707 3.19944   1.000 13.96875 ? 68  PRO   A CB  1 
ATOM   515  C  CG  . PRO   A 1 68  ? -39.05621 34.99073 2.41429   1.000 11.72321 ? 68  PRO   A CG  1 
ATOM   516  C  CD  . PRO   A 1 68  ? -38.91134 33.49591 2.20769   1.000 17.34313 ? 68  PRO   A CD  1 
ATOM   517  N  N   . GLU   A 1 69  ? -39.53565 33.94083 5.64129   1.000 18.20848 ? 69  GLU   A N   1 
ATOM   518  C  CA  . GLU   A 1 69  ? -40.20881 33.85207 6.92894   1.000 16.61314 ? 69  GLU   A CA  1 
ATOM   519  C  C   . GLU   A 1 69  ? -40.73597 32.43296 7.05947   1.000 16.79933 ? 69  GLU   A C   1 
ATOM   520  O  O   . GLU   A 1 69  ? -41.06800 31.80220 6.05557   1.000 19.20940 ? 69  GLU   A O   1 
ATOM   521  C  CB  . GLU   A 1 69  ? -41.37801 34.86850 7.05657   1.000 22.74156 ? 69  GLU   A CB  1 
ATOM   522  C  CG  . GLU   A 1 69  ? -41.06345 36.32028 6.64979   1.000 26.96861 ? 69  GLU   A CG  1 
ATOM   523  C  CD  . GLU   A 1 69  ? -42.28736 37.24962 6.74069   1.000 29.83746 ? 69  GLU   A CD  1 
ATOM   524  O  OE1 . GLU   A 1 69  ? -43.26459 36.89774 7.42923   1.000 42.43876 ? 69  GLU   A OE1 1 
ATOM   525  O  OE2 . GLU   A 1 69  ? -42.27490 38.33959 6.12991   1.000 35.41064 ? 69  GLU   A OE2 1 
ATOM   526  N  N   . GLU   A 1 70  ? -40.79181 31.91565 8.28677   1.000 15.27192 ? 70  GLU   A N   1 
ATOM   527  C  CA  . GLU   A 1 70  ? -41.22360 30.53377 8.46360   1.000 16.88889 ? 70  GLU   A CA  1 
ATOM   528  C  C   . GLU   A 1 70  ? -42.65833 30.34323 7.98582   1.000 20.18306 ? 70  GLU   A C   1 
ATOM   529  O  O   . GLU   A 1 70  ? -43.56973 31.06032 8.41014   1.000 19.38888 ? 70  GLU   A O   1 
ATOM   530  C  CB  . GLU   A 1 70  ? -41.11008 30.11908 9.91865   1.000 16.91545 ? 70  GLU   A CB  1 
ATOM   531  C  CG  . GLU   A 1 70  ? -41.37438 28.65265 10.13300  1.000 16.62127 ? 70  GLU   A CG  1 
ATOM   532  C  CD  . GLU   A 1 70  ? -41.18613 28.24712 11.57602  1.000 21.93688 ? 70  GLU   A CD  1 
ATOM   533  O  OE1 . GLU   A 1 70  ? -41.06874 29.14746 12.44369  1.000 22.88499 ? 70  GLU   A OE1 1 
ATOM   534  O  OE2 . GLU   A 1 70  ? -41.13858 27.03148 11.83691  1.000 19.73520 ? 70  GLU   A OE2 1 
ATOM   535  N  N   . GLY   A 1 71  ? -42.85577 29.36724 7.09773   1.000 17.16405 ? 71  GLY   A N   1 
ATOM   536  C  CA  . GLY   A 1 71  ? -44.14417 29.12958 6.48059   1.000 16.46780 ? 71  GLY   A CA  1 
ATOM   537  C  C   . GLY   A 1 71  ? -44.37894 29.88539 5.18997   1.000 19.69272 ? 71  GLY   A C   1 
ATOM   538  O  O   . GLY   A 1 71  ? -45.34836 29.58624 4.48068   1.000 15.98736 ? 71  GLY   A O   1 
ATOM   539  N  N   . LYS   A 1 72  ? -43.51843 30.84278 4.85419   1.000 15.58581 ? 72  LYS   A N   1 
ATOM   540  C  CA  . LYS   A 1 72  ? -43.67278 31.66250 3.65796   1.000 17.81650 ? 72  LYS   A CA  1 
ATOM   541  C  C   . LYS   A 1 72  ? -42.69324 31.13988 2.61835   1.000 19.51230 ? 72  LYS   A C   1 
ATOM   542  O  O   . LYS   A 1 72  ? -41.49548 31.42128 2.68767   1.000 18.87721 ? 72  LYS   A O   1 
ATOM   543  C  CB  . LYS   A 1 72  ? -43.42092 33.13152 3.99133   1.000 19.17422 ? 72  LYS   A CB  1 
ATOM   544  C  CG  . LYS   A 1 72  ? -44.14903 34.12468 3.10946   1.000 33.63877 ? 72  LYS   A CG  1 
ATOM   545  C  CD  . LYS   A 1 72  ? -44.27326 35.48693 3.79096   1.000 37.30594 ? 72  LYS   A CD  1 
ATOM   546  C  CE  . LYS   A 1 72  ? -44.94772 35.36785 5.16715   1.000 38.46302 ? 72  LYS   A CE  1 
ATOM   547  N  NZ  . LYS   A 1 72  ? -46.43403 35.51113 5.12791   1.000 39.23288 ? 72  LYS   A NZ  1 
ATOM   548  N  N   . PHE   A 1 73  ? -43.19682 30.35649 1.66895   1.000 19.70052 ? 73  PHE   A N   1 
ATOM   549  C  CA  . PHE   A 1 73  ? -42.37567 29.77626 0.61506   1.000 19.23520 ? 73  PHE   A CA  1 
ATOM   550  C  C   . PHE   A 1 73  ? -42.57568 30.55164 -0.68263  1.000 24.70792 ? 73  PHE   A C   1 
ATOM   551  O  O   . PHE   A 1 73  ? -43.71183 30.73194 -1.13147  1.000 23.13065 ? 73  PHE   A O   1 
ATOM   552  C  CB  . PHE   A 1 73  ? -42.70661 28.29596 0.41074   1.000 17.40330 ? 73  PHE   A CB  1 
ATOM   553  C  CG  . PHE   A 1 73  ? -42.24019 27.42043 1.53586   1.000 20.27223 ? 73  PHE   A CG  1 
ATOM   554  C  CD1 . PHE   A 1 73  ? -43.05685 27.18252 2.63619   1.000 16.52115 ? 73  PHE   A CD1 1 
ATOM   555  C  CD2 . PHE   A 1 73  ? -40.97644 26.86190 1.51179   1.000 13.53698 ? 73  PHE   A CD2 1 
ATOM   556  C  CE1 . PHE   A 1 73  ? -42.62169 26.39097 3.68560   1.000 17.76443 ? 73  PHE   A CE1 1 
ATOM   557  C  CE2 . PHE   A 1 73  ? -40.52739 26.06653 2.56539   1.000 19.48260 ? 73  PHE   A CE2 1 
ATOM   558  C  CZ  . PHE   A 1 73  ? -41.35473 25.82690 3.65368   1.000 17.54283 ? 73  PHE   A CZ  1 
ATOM   559  N  N   . ASN   A 1 74  ? -41.47166 31.01384 -1.27245  1.000 20.47912 ? 74  ASN   A N   1 
ATOM   560  C  CA  . ASN   A 1 74  ? -41.47462 31.75840 -2.53042  1.000 23.19589 ? 74  ASN   A CA  1 
ATOM   561  C  C   . ASN   A 1 74  ? -40.74472 30.90991 -3.56358  1.000 20.03145 ? 74  ASN   A C   1 
ATOM   562  O  O   . ASN   A 1 74  ? -39.52684 31.00792 -3.69029  1.000 18.05373 ? 74  ASN   A O   1 
ATOM   563  C  CB  . ASN   A 1 74  ? -40.80403 33.12847 -2.37478  1.000 22.90136 ? 74  ASN   A CB  1 
ATOM   564  C  CG  . ASN   A 1 74  ? -41.56946 34.06182 -1.43870  1.000 36.25895 ? 74  ASN   A CG  1 
ATOM   565  O  OD1 . ASN   A 1 74  ? -42.79969 34.01468 -1.35837  1.000 41.51905 ? 74  ASN   A OD1 1 
ATOM   566  N  ND2 . ASN   A 1 74  ? -40.83664 34.92988 -0.73036  1.000 42.35074 ? 74  ASN   A ND2 1 
ATOM   567  N  N   . PHE   A 1 75  ? -41.48335 30.07758 -4.28785  1.000 15.78939 ? 75  PHE   A N   1 
ATOM   568  C  CA  . PHE   A 1 75  ? -40.92981 29.28326 -5.38291  1.000 17.56724 ? 75  PHE   A CA  1 
ATOM   569  C  C   . PHE   A 1 75  ? -41.07889 29.94271 -6.74670  1.000 18.74432 ? 75  PHE   A C   1 
ATOM   570  O  O   . PHE   A 1 75  ? -40.66375 29.34523 -7.74328  1.000 17.98188 ? 75  PHE   A O   1 
ATOM   571  C  CB  . PHE   A 1 75  ? -41.60943 27.91484 -5.46977  1.000 12.14798 ? 75  PHE   A CB  1 
ATOM   572  C  CG  . PHE   A 1 75  ? -41.35297 27.02616 -4.29890  1.000 18.31332 ? 75  PHE   A CG  1 
ATOM   573  C  CD1 . PHE   A 1 75  ? -40.08720 26.50587 -4.06713  1.000 18.47783 ? 75  PHE   A CD1 1 
ATOM   574  C  CD2 . PHE   A 1 75  ? -42.38116 26.70584 -3.42006  1.000 15.64885 ? 75  PHE   A CD2 1 
ATOM   575  C  CE1 . PHE   A 1 75  ? -39.85510 25.67157 -2.99247  1.000 13.97658 ? 75  PHE   A CE1 1 
ATOM   576  C  CE2 . PHE   A 1 75  ? -42.15275 25.87644 -2.34938  1.000 13.88290 ? 75  PHE   A CE2 1 
ATOM   577  C  CZ  . PHE   A 1 75  ? -40.89431 25.35960 -2.12637  1.000 15.63897 ? 75  PHE   A CZ  1 
ATOM   578  N  N   . GLU   A 1 76  ? -41.68909 31.12915 -6.82672  1.000 17.84973 ? 76  GLU   A N   1 
ATOM   579  C  CA  . GLU   A 1 76  ? -42.01775 31.70835 -8.12904  1.000 17.63817 ? 76  GLU   A CA  1 
ATOM   580  C  C   . GLU   A 1 76  ? -40.77100 31.93066 -8.98477  1.000 21.05032 ? 76  GLU   A C   1 
ATOM   581  O  O   . GLU   A 1 76  ? -40.77411 31.65074 -10.18970 1.000 16.34385 ? 76  GLU   A O   1 
ATOM   582  C  CB  . GLU   A 1 76  ? -42.77421 33.02839 -7.93494  1.000 26.44276 ? 76  GLU   A CB  1 
ATOM   583  C  CG  . GLU   A 1 76  ? -43.37517 33.58417 -9.22564  1.000 32.88705 ? 76  GLU   A CG  1 
ATOM   584  C  CD  . GLU   A 1 76  ? -43.56289 35.10016 -9.19704  1.000 53.98155 ? 76  GLU   A CD  1 
ATOM   585  O  OE1 . GLU   A 1 76  ? -44.73482 35.56814 -9.30153  1.000 49.54570 ? 76  GLU   A OE1 1 
ATOM   586  O  OE2 . GLU   A 1 76  ? -42.53557 35.81843 -9.08488  1.000 52.57557 ? 76  GLU   A OE2 1 
ATOM   587  N  N   . GLN   A 1 77  ? -39.69568 32.43870 -8.38143  1.000 19.69971 ? 77  GLN   A N   1 
ATOM   588  C  CA  . GLN   A 1 77  ? -38.47965 32.69809 -9.14694  1.000 21.52589 ? 77  GLN   A CA  1 
ATOM   589  C  C   . GLN   A 1 77  ? -37.77173 31.39723 -9.50896  1.000 17.32609 ? 77  GLN   A C   1 
ATOM   590  O  O   . GLN   A 1 77  ? -37.35047 31.20987 -10.65529 1.000 16.41272 ? 77  GLN   A O   1 
ATOM   591  C  CB  . GLN   A 1 77  ? -37.55920 33.62685 -8.35577  1.000 20.23581 ? 77  GLN   A CB  1 
ATOM   592  C  CG  . GLN   A 1 77  ? -38.12406 35.03599 -8.19055  1.000 18.75194 ? 77  GLN   A CG  1 
ATOM   593  C  CD  . GLN   A 1 77  ? -37.85421 35.88813 -9.41526  1.000 34.49233 ? 77  GLN   A CD  1 
ATOM   594  O  OE1 . GLN   A 1 77  ? -38.65401 35.92558 -10.36033 1.000 40.47775 ? 77  GLN   A OE1 1 
ATOM   595  N  NE2 . GLN   A 1 77  ? -36.70715 36.56541 -9.41573  1.000 32.01165 ? 77  GLN   A NE2 1 
ATOM   596  N  N   . ALA   A 1 78  ? -37.65394 30.47601 -8.54389  1.000 16.54781 ? 78  ALA   A N   1 
ATOM   597  C  CA  . ALA   A 1 78  ? -37.04109 29.17786 -8.81607  1.000 15.35214 ? 78  ALA   A CA  1 
ATOM   598  C  C   . ALA   A 1 78  ? -37.80280 28.42363 -9.90038  1.000 17.60064 ? 78  ALA   A C   1 
ATOM   599  O  O   . ALA   A 1 78  ? -37.18857 27.78656 -10.76748 1.000 16.44582 ? 78  ALA   A O   1 
ATOM   600  C  CB  . ALA   A 1 78  ? -36.96376 28.34975 -7.52973  1.000 14.04682 ? 78  ALA   A CB  1 
ATOM   601  N  N   . ASP   A 1 79  ? -39.14262 28.49210 -9.87249  1.000 16.67012 ? 79  ASP   A N   1 
ATOM   602  C  CA  . ASP   A 1 79  ? -39.95099 27.83161 -10.89530 1.000 17.01889 ? 79  ASP   A CA  1 
ATOM   603  C  C   . ASP   A 1 79  ? -39.57413 28.30491 -12.29681 1.000 16.17466 ? 79  ASP   A C   1 
ATOM   604  O  O   . ASP   A 1 79  ? -39.53864 27.50845 -13.23885 1.000 15.65344 ? 79  ASP   A O   1 
ATOM   605  C  CB  . ASP   A 1 79  ? -41.44286 28.08569 -10.66056 1.000 15.86787 ? 79  ASP   A CB  1 
ATOM   606  C  CG  . ASP   A 1 79  ? -42.00736 27.31867 -9.47289  1.000 19.07865 ? 79  ASP   A CG  1 
ATOM   607  O  OD1 . ASP   A 1 79  ? -41.36504 26.37382 -8.96123  1.000 18.24879 ? 79  ASP   A OD1 1 
ATOM   608  O  OD2 . ASP   A 1 79  ? -43.12819 27.66994 -9.05067  1.000 18.19766 ? 79  ASP   A OD2 1 
ATOM   609  N  N   . ARG   A 1 80  ? -39.32851 29.60372 -12.46280 1.000 15.98581 ? 80  ARG   A N   1 
ATOM   610  C  CA  . ARG   A 1 80  ? -38.99105 30.12278 -13.78188 1.000 16.71741 ? 80  ARG   A CA  1 
ATOM   611  C  C   . ARG   A 1 80  ? -37.73062 29.46289 -14.33227 1.000 18.68917 ? 80  ARG   A C   1 
ATOM   612  O  O   . ARG   A 1 80  ? -37.65292 29.15120 -15.52343 1.000 16.49990 ? 80  ARG   A O   1 
ATOM   613  C  CB  . ARG   A 1 80  ? -38.81010 31.63547 -13.71100 1.000 19.48658 ? 80  ARG   A CB  1 
ATOM   614  C  CG  . ARG   A 1 80  ? -40.09017 32.40752 -13.61506 1.000 21.94069 ? 80  ARG   A CG  1 
ATOM   615  C  CD  . ARG   A 1 80  ? -39.81420 33.89290 -13.45380 1.000 31.45369 ? 80  ARG   A CD  1 
ATOM   616  N  NE  . ARG   A 1 80  ? -40.83914 34.53755 -12.64216 1.000 43.23802 ? 80  ARG   A NE  1 
ATOM   617  C  CZ  . ARG   A 1 80  ? -42.03624 34.89209 -13.10053 1.000 49.99196 ? 80  ARG   A CZ  1 
ATOM   618  N  NH1 . ARG   A 1 80  ? -42.35445 34.66915 -14.37483 1.000 47.65055 ? 80  ARG   A NH1 1 
ATOM   619  N  NH2 . ARG   A 1 80  ? -42.91375 35.47086 -12.28607 1.000 45.16505 ? 80  ARG   A NH2 1 
ATOM   620  N  N   . ILE   A 1 81  ? -36.73284 29.24369 -13.47758 1.000 15.57967 ? 81  ILE   A N   1 
ATOM   621  C  CA  . ILE   A 1 81  ? -35.51659 28.57606 -13.91355 1.000 14.37324 ? 81  ILE   A CA  1 
ATOM   622  C  C   . ILE   A 1 81  ? -35.79194 27.11231 -14.25174 1.000 16.52618 ? 81  ILE   A C   1 
ATOM   623  O  O   . ILE   A 1 81  ? -35.33295 26.60758 -15.28433 1.000 15.88572 ? 81  ILE   A O   1 
ATOM   624  C  CB  . ILE   A 1 81  ? -34.42624 28.74069 -12.83722 1.000 18.81377 ? 81  ILE   A CB  1 
ATOM   625  C  CG1 . ILE   A 1 81  ? -33.97765 30.20873 -12.79103 1.000 14.85361 ? 81  ILE   A CG1 1 
ATOM   626  C  CG2 . ILE   A 1 81  ? -33.23290 27.83338 -13.11308 1.000 10.82001 ? 81  ILE   A CG2 1 
ATOM   627  C  CD1 . ILE   A 1 81  ? -32.96340 30.49942 -11.73856 1.000 15.50683 ? 81  ILE   A CD1 1 
ATOM   628  N  N   . VAL   A 1 82  ? -36.54952 26.40857 -13.40232 1.000 16.66206 ? 82  VAL   A N   1 
ATOM   629  C  CA  . VAL   A 1 82  ? -36.90150 25.01673 -13.69098 1.000 13.82215 ? 82  VAL   A CA  1 
ATOM   630  C  C   . VAL   A 1 82  ? -37.66453 24.91916 -15.01195 1.000 16.54781 ? 82  VAL   A C   1 
ATOM   631  O  O   . VAL   A 1 82  ? -37.39319 24.03911 -15.84159 1.000 14.39897 ? 82  VAL   A O   1 
ATOM   632  C  CB  . VAL   A 1 82  ? -37.70779 24.41360 -12.52185 1.000 13.55633 ? 82  VAL   A CB  1 
ATOM   633  C  CG1 . VAL   A 1 82  ? -38.30810 23.05506 -12.90032 1.000 12.16618 ? 82  VAL   A CG1 1 
ATOM   634  C  CG2 . VAL   A 1 82  ? -36.83729 24.27458 -11.29630 1.000 12.65737 ? 82  VAL   A CG2 1 
ATOM   635  N  N   . LYS   A 1 83  ? -38.61909 25.82833 -15.23520 1.000 15.58931 ? 83  LYS   A N   1 
ATOM   636  C  CA  . LYS   A 1 83  ? -39.40187 25.79081 -16.46620 1.000 19.05072 ? 83  LYS   A CA  1 
ATOM   637  C  C   . LYS   A 1 83  ? -38.50910 25.95911 -17.69028 1.000 17.88485 ? 83  LYS   A C   1 
ATOM   638  O  O   . LYS   A 1 83  ? -38.64545 25.22579 -18.67505 1.000 16.41900 ? 83  LYS   A O   1 
ATOM   639  C  CB  . LYS   A 1 83  ? -40.47745 26.87578 -16.44149 1.000 17.10906 ? 83  LYS   A CB  1 
ATOM   640  C  CG  . LYS   A 1 83  ? -41.39172 26.82876 -17.65415 1.000 27.28952 ? 83  LYS   A CG  1 
ATOM   641  C  CD  . LYS   A 1 83  ? -42.44234 27.93589 -17.63948 1.000 33.48859 ? 83  LYS   A CD  1 
ATOM   642  C  CE  . LYS   A 1 83  ? -41.89380 29.25912 -18.13907 1.000 38.09864 ? 83  LYS   A CE  1 
ATOM   643  N  NZ  . LYS   A 1 83  ? -42.90253 30.36062 -18.08136 1.000 47.44649 ? 83  LYS   A NZ  1 
ATOM   644  N  N   . PHE   A 1 84  ? -37.57684 26.91092 -17.63591 1.000 16.60861 ? 84  PHE   A N   1 
ATOM   645  C  CA  . PHE   A 1 84  ? -36.71269 27.16921 -18.78167 1.000 16.96090 ? 84  PHE   A CA  1 
ATOM   646  C  C   . PHE   A 1 84  ? -35.83517 25.96171 -19.07543 1.000 15.11367 ? 84  PHE   A C   1 
ATOM   647  O  O   . PHE   A 1 84  ? -35.68018 25.55804 -20.23363 1.000 15.45279 ? 84  PHE   A O   1 
ATOM   648  C  CB  . PHE   A 1 84  ? -35.86552 28.42159 -18.52260 1.000 15.15239 ? 84  PHE   A CB  1 
ATOM   649  C  CG  . PHE   A 1 84  ? -34.93549 28.76777 -19.65236 1.000 16.28632 ? 84  PHE   A CG  1 
ATOM   650  C  CD1 . PHE   A 1 84  ? -35.36673 29.55507 -20.70743 1.000 16.09502 ? 84  PHE   A CD1 1 
ATOM   651  C  CD2 . PHE   A 1 84  ? -33.63822 28.30323 -19.66479 1.000 14.34878 ? 84  PHE   A CD2 1 
ATOM   652  C  CE1 . PHE   A 1 84  ? -34.51893 29.87887 -21.75640 1.000 15.02249 ? 84  PHE   A CE1 1 
ATOM   653  C  CE2 . PHE   A 1 84  ? -32.77807 28.63032 -20.71268 1.000 17.22393 ? 84  PHE   A CE2 1 
ATOM   654  C  CZ  . PHE   A 1 84  ? -33.22477 29.41719 -21.75975 1.000 13.95062 ? 84  PHE   A CZ  1 
ATOM   655  N  N   . ALA   A 1 85  ? -35.26604 25.36436 -18.02886 1.000 18.94698 ? 85  ALA   A N   1 
ATOM   656  C  CA  . ALA   A 1 85  ? -34.42105 24.19410 -18.20317 1.000 15.30744 ? 85  ALA   A CA  1 
ATOM   657  C  C   . ALA   A 1 85  ? -35.19902 23.05263 -18.83939 1.000 17.33404 ? 85  ALA   A C   1 
ATOM   658  O  O   . ALA   A 1 85  ? -34.73159 22.42678 -19.79963 1.000 16.49610 ? 85  ALA   A O   1 
ATOM   659  C  CB  . ALA   A 1 85  ? -33.85392 23.76299 -16.85103 1.000 15.17267 ? 85  ALA   A CB  1 
ATOM   660  N  N   . LYS   A 1 86  ? -36.38339 22.74870 -18.29778 1.000 17.51752 ? 86  LYS   A N   1 
ATOM   661  C  CA  . LYS   A 1 86  ? -37.18218 21.66774 -18.86255 1.000 19.87186 ? 86  LYS   A CA  1 
ATOM   662  C  C   . LYS   A 1 86  ? -37.47506 21.92397 -20.33444 1.000 18.15763 ? 86  LYS   A C   1 
ATOM   663  O  O   . LYS   A 1 86  ? -37.31911 21.03013 -21.16581 1.000 19.74696 ? 86  LYS   A O   1 
ATOM   664  C  CB  . LYS   A 1 86  ? -38.47596 21.49081 -18.06896 1.000 24.20536 ? 86  LYS   A CB  1 
ATOM   665  C  CG  . LYS   A 1 86  ? -38.33333 20.54306 -16.87378 1.000 27.89332 ? 86  LYS   A CG  1 
ATOM   666  C  CD  . LYS   A 1 86  ? -39.34421 20.85434 -15.75814 1.000 32.48698 ? 86  LYS   A CD  1 
ATOM   667  C  CE  . LYS   A 1 86  ? -40.68675 20.17779 -16.00337 1.000 32.92825 ? 86  LYS   A CE  1 
ATOM   668  N  NZ  . LYS   A 1 86  ? -40.50245 18.70734 -16.15026 1.000 42.66881 ? 86  LYS   A NZ  1 
ATOM   669  N  N   . ALA   A 1 87  ? -37.85399 23.15310 -20.68279 1.000 17.04104 ? 87  ALA   A N   1 
ATOM   670  C  CA  . ALA   A 1 87  ? -38.16770 23.46617 -22.07311 1.000 15.55753 ? 87  ALA   A CA  1 
ATOM   671  C  C   . ALA   A 1 87  ? -36.95521 23.33562 -22.99409 1.000 19.76894 ? 87  ALA   A C   1 
ATOM   672  O  O   . ALA   A 1 87  ? -37.12775 23.20437 -24.20537 1.000 15.06323 ? 87  ALA   A O   1 
ATOM   673  C  CB  . ALA   A 1 87  ? -38.74514 24.88214 -22.17306 1.000 18.73265 ? 87  ALA   A CB  1 
ATOM   674  N  N   . ASN   A 1 88  ? -35.73299 23.35016 -22.46280 1.000 16.62377 ? 88  ASN   A N   1 
ATOM   675  C  CA  . ASN   A 1 88  ? -34.55295 23.29578 -23.32191 1.000 17.98228 ? 88  ASN   A CA  1 
ATOM   676  C  C   . ASN   A 1 88  ? -33.67945 22.07482 -23.04947 1.000 14.57230 ? 88  ASN   A C   1 
ATOM   677  O  O   . ASN   A 1 88  ? -32.53526 22.02677 -23.50255 1.000 20.33705 ? 88  ASN   A O   1 
ATOM   678  C  CB  . ASN   A 1 88  ? -33.74330 24.59151 -23.19250 1.000 14.53871 ? 88  ASN   A CB  1 
ATOM   679  C  CG  . ASN   A 1 88  ? -34.52791 25.81562 -23.68013 1.000 20.07376 ? 88  ASN   A CG  1 
ATOM   680  O  OD1 . ASN   A 1 88  ? -34.51864 26.12893 -24.86526 1.000 18.60623 ? 88  ASN   A OD1 1 
ATOM   681  N  ND2 . ASN   A 1 88  ? -35.21920 26.50174 -22.76170 1.000 16.15537 ? 88  ASN   A ND2 1 
ATOM   682  N  N   . GLY   A 1 89  ? -34.19764 21.07346 -22.34533 1.000 18.34504 ? 89  GLY   A N   1 
ATOM   683  C  CA  . GLY   A 1 89  ? -33.44393 19.84372 -22.13851 1.000 16.29594 ? 89  GLY   A CA  1 
ATOM   684  C  C   . GLY   A 1 89  ? -32.18131 20.01797 -21.31877 1.000 16.50286 ? 89  GLY   A C   1 
ATOM   685  O  O   . GLY   A 1 89  ? -31.19277 19.31257 -21.54949 1.000 22.28104 ? 89  GLY   A O   1 
ATOM   686  N  N   . MET   A 1 90  ? -32.19211 20.93875 -20.36135 1.000 15.02393 ? 90  MET   A N   1 
ATOM   687  C  CA  . MET   A 1 90  ? -31.04263 21.21028 -19.51274 1.000 13.70771 ? 90  MET   A CA  1 
ATOM   688  C  C   . MET   A 1 90  ? -31.16159 20.46498 -18.18524 1.000 18.15506 ? 90  MET   A C   1 
ATOM   689  O  O   . MET   A 1 90  ? -32.24404 20.40371 -17.59616 1.000 15.62287 ? 90  MET   A O   1 
ATOM   690  C  CB  . MET   A 1 90  ? -30.92331 22.71977 -19.24576 1.000 13.50676 ? 90  MET   A CB  1 
ATOM   691  C  CG  . MET   A 1 90  ? -30.89782 23.61250 -20.49986 1.000 12.92471 ? 90  MET   A CG  1 
ATOM   692  S  SD  . MET   A 1 90  ? -30.81384 25.37345 -20.07171 1.000 13.70667 ? 90  MET   A SD  1 
ATOM   693  C  CE  . MET   A 1 90  ? -29.03961 25.51870 -19.84990 1.000 9.00278  ? 90  MET   A CE  1 
ATOM   694  N  N   . ASP   A 1 91  ? -30.03931 19.91681 -17.70804 1.000 15.67084 ? 91  ASP   A N   1 
ATOM   695  C  CA  . ASP   A 1 91  ? -29.94858 19.49301 -16.31555 1.000 16.38241 ? 91  ASP   A CA  1 
ATOM   696  C  C   . ASP   A 1 91  ? -30.10920 20.69881 -15.38297 1.000 16.70828 ? 91  ASP   A C   1 
ATOM   697  O  O   . ASP   A 1 91  ? -29.83890 21.84615 -15.75134 1.000 16.32016 ? 91  ASP   A O   1 
ATOM   698  C  CB  . ASP   A 1 91  ? -28.60010 18.82957 -16.02614 1.000 17.83604 ? 91  ASP   A CB  1 
ATOM   699  C  CG  . ASP   A 1 91  ? -28.47254 17.42929 -16.61448 1.000 19.71174 ? 91  ASP   A CG  1 
ATOM   700  O  OD1 . ASP   A 1 91  ? -29.47231 16.89120 -17.13911 1.000 19.05149 ? 91  ASP   A OD1 1 
ATOM   701  O  OD2 . ASP   A 1 91  ? -27.34892 16.87495 -16.54844 1.000 17.09221 ? 91  ASP   A OD2 1 
ATOM   702  N  N   . ILE   A 1 92  ? -30.53699 20.42569 -14.15415 1.000 12.31782 ? 92  ILE   A N   1 
ATOM   703  C  CA  . ILE   A 1 92  ? -30.70762 21.44707 -13.12390 1.000 14.97376 ? 92  ILE   A CA  1 
ATOM   704  C  C   . ILE   A 1 92  ? -29.91399 21.02875 -11.89204 1.000 14.37248 ? 92  ILE   A C   1 
ATOM   705  O  O   . ILE   A 1 92  ? -29.99753 19.87181 -11.46119 1.000 14.27198 ? 92  ILE   A O   1 
ATOM   706  C  CB  . ILE   A 1 92  ? -32.19097 21.64535 -12.75773 1.000 12.42675 ? 92  ILE   A CB  1 
ATOM   707  C  CG1 . ILE   A 1 92  ? -33.05091 21.84625 -14.01286 1.000 13.97974 ? 92  ILE   A CG1 1 
ATOM   708  C  CG2 . ILE   A 1 92  ? -32.36976 22.83092 -11.79121 1.000 12.46004 ? 92  ILE   A CG2 1 
ATOM   709  C  CD1 . ILE   A 1 92  ? -34.55105 21.85032 -13.71359 1.000 9.27648  ? 92  ILE   A CD1 1 
ATOM   710  N  N   . ARG   A 1 93  ? -29.15481 21.96423 -11.32502 1.000 13.41988 ? 93  ARG   A N   1 
ATOM   711  C  CA  . ARG   A 1 93  ? -28.58084 21.81180 -9.99541  1.000 11.93604 ? 93  ARG   A CA  1 
ATOM   712  C  C   . ARG   A 1 93  ? -29.34966 22.70980 -9.02847  1.000 12.74243 ? 93  ARG   A C   1 
ATOM   713  O  O   . ARG   A 1 93  ? -29.65918 23.85670 -9.35728  1.000 9.83214  ? 93  ARG   A O   1 
ATOM   714  C  CB  . ARG   A 1 93  ? -27.07784 22.17086 -9.98163  1.000 13.03088 ? 93  ARG   A CB  1 
ATOM   715  C  CG  . ARG   A 1 93  ? -26.22368 21.48131 -11.07594 1.000 13.39402 ? 93  ARG   A CG  1 
ATOM   716  C  CD  . ARG   A 1 93  ? -24.70755 21.63688 -10.85404 1.000 12.70908 ? 93  ARG   A CD  1 
ATOM   717  N  NE  . ARG   A 1 93  ? -24.27004 20.76265 -9.77736  1.000 12.87588 ? 93  ARG   A NE  1 
ATOM   718  C  CZ  . ARG   A 1 93  ? -24.11795 21.14662 -8.51458  1.000 15.02194 ? 93  ARG   A CZ  1 
ATOM   719  N  NH1 . ARG   A 1 93  ? -24.34139 22.41374 -8.16578  1.000 14.58986 ? 93  ARG   A NH1 1 
ATOM   720  N  NH2 . ARG   A 1 93  ? -23.74670 20.25156 -7.59559  1.000 14.75920 ? 93  ARG   A NH2 1 
ATOM   721  N  N   . PHE   A 1 94  ? -29.65277 22.20090 -7.83071  1.000 11.88990 ? 94  PHE   A N   1 
ATOM   722  C  CA  . PHE   A 1 94  ? -30.26169 23.03169 -6.79726  1.000 11.02314 ? 94  PHE   A CA  1 
ATOM   723  C  C   . PHE   A 1 94  ? -29.19685 23.60565 -5.86613  1.000 13.23061 ? 94  PHE   A C   1 
ATOM   724  O  O   . PHE   A 1 94  ? -28.52585 22.85725 -5.14219  1.000 12.24489 ? 94  PHE   A O   1 
ATOM   725  C  CB  . PHE   A 1 94  ? -31.28438 22.25946 -5.97272  1.000 13.35809 ? 94  PHE   A CB  1 
ATOM   726  C  CG  . PHE   A 1 94  ? -32.03117 23.13394 -4.99881  1.000 13.94335 ? 94  PHE   A CG  1 
ATOM   727  C  CD1 . PHE   A 1 94  ? -31.47713 23.46094 -3.75836  1.000 12.68507 ? 94  PHE   A CD1 1 
ATOM   728  C  CD2 . PHE   A 1 94  ? -33.26411 23.66483 -5.33598  1.000 13.30771 ? 94  PHE   A CD2 1 
ATOM   729  C  CE1 . PHE   A 1 94  ? -32.15639 24.28661 -2.86681  1.000 11.54777 ? 94  PHE   A CE1 1 
ATOM   730  C  CE2 . PHE   A 1 94  ? -33.95432 24.48726 -4.43807  1.000 11.37664 ? 94  PHE   A CE2 1 
ATOM   731  C  CZ  . PHE   A 1 94  ? -33.40703 24.79230 -3.21922  1.000 10.46072 ? 94  PHE   A CZ  1 
ATOM   732  N  N   . HIS   A 1 95  ? -29.09646 24.93678 -5.83447  1.000 12.73630 ? 95  HIS   A N   1 
ATOM   733  C  CA  . HIS   A 1 95  ? -28.16461 25.65094 -4.96316  1.000 13.86635 ? 95  HIS   A CA  1 
ATOM   734  C  C   . HIS   A 1 95  ? -28.96152 26.61707 -4.09031  1.000 10.61091 ? 95  HIS   A C   1 
ATOM   735  O  O   . HIS   A 1 95  ? -29.51842 27.58892 -4.61122  1.000 10.89896 ? 95  HIS   A O   1 
ATOM   736  C  CB  . HIS   A 1 95  ? -27.13263 26.40680 -5.80194  1.000 11.20805 ? 95  HIS   A CB  1 
ATOM   737  C  CG  . HIS   A 1 95  ? -26.10901 27.14401 -4.99298  1.000 11.87052 ? 95  HIS   A CG  1 
ATOM   738  N  ND1 . HIS   A 1 95  ? -25.04072 26.51318 -4.39563  1.000 15.27469 ? 95  HIS   A ND1 1 
ATOM   739  C  CD2 . HIS   A 1 95  ? -25.99207 28.45712 -4.68104  1.000 13.64368 ? 95  HIS   A CD2 1 
ATOM   740  C  CE1 . HIS   A 1 95  ? -24.31514 27.40254 -3.74215  1.000 13.62384 ? 95  HIS   A CE1 1 
ATOM   741  N  NE2 . HIS   A 1 95  ? -24.86587 28.59116 -3.90540  1.000 13.91200 ? 95  HIS   A NE2 1 
ATOM   742  N  N   . THR   A 1 96  ? -29.02731 26.38371 -2.76961  1.000 11.98909 ? 96  THR   A N   1 
ATOM   743  C  CA  . THR   A 1 96  ? -28.46361 25.25057 -2.01991  1.000 14.10909 ? 96  THR   A CA  1 
ATOM   744  C  C   . THR   A 1 96  ? -29.37760 25.05507 -0.79548  1.000 13.75937 ? 96  THR   A C   1 
ATOM   745  O  O   . THR   A 1 96  ? -30.01896 26.00166 -0.35929  1.000 12.72905 ? 96  THR   A O   1 
ATOM   746  C  CB  . THR   A 1 96  ? -26.98038 25.50156 -1.55907  1.000 12.50692 ? 96  THR   A CB  1 
ATOM   747  O  OG1 . THR   A 1 96  ? -26.57116 24.46680 -0.66354  1.000 13.15304 ? 96  THR   A OG1 1 
ATOM   748  C  CG2 . THR   A 1 96  ? -26.86367 26.80879 -0.81487  1.000 11.62751 ? 96  THR   A CG2 1 
ATOM   749  N  N   . LEU   A 1 97  ? -29.43314 23.84310 -0.23076  1.000 14.30043 ? 97  LEU   A N   1 
ATOM   750  C  CA  . LEU   A 1 97  ? -30.40047 23.57521 0.83111   1.000 12.21911 ? 97  LEU   A CA  1 
ATOM   751  C  C   . LEU   A 1 97  ? -29.96749 24.13850 2.18075   1.000 18.42904 ? 97  LEU   A C   1 
ATOM   752  O  O   . LEU   A 1 97  ? -30.82787 24.52834 2.97815   1.000 15.35296 ? 97  LEU   A O   1 
ATOM   753  C  CB  . LEU   A 1 97  ? -30.66273 22.06431 0.96148   1.000 12.37217 ? 97  LEU   A CB  1 
ATOM   754  C  CG  . LEU   A 1 97  ? -31.51976 21.41371 -0.14148  1.000 14.76618 ? 97  LEU   A CG  1 
ATOM   755  C  CD1 . LEU   A 1 97  ? -31.55420 19.87695 -0.02011  1.000 10.75807 ? 97  LEU   A CD1 1 
ATOM   756  C  CD2 . LEU   A 1 97  ? -32.93757 21.99597 -0.19008  1.000 11.15941 ? 97  LEU   A CD2 1 
ATOM   757  N  N   . VAL   A 1 98  ? -28.66157 24.19534 2.45910   1.000 13.85039 ? 98  VAL   A N   1 
ATOM   758  C  CA  . VAL   A 1 98  ? -28.14599 24.61489 3.76170   1.000 15.44816 ? 98  VAL   A CA  1 
ATOM   759  C  C   . VAL   A 1 98  ? -26.89703 25.46860 3.55288   1.000 16.43396 ? 98  VAL   A C   1 
ATOM   760  O  O   . VAL   A 1 98  ? -25.98052 25.06248 2.82711   1.000 16.48839 ? 98  VAL   A O   1 
ATOM   761  C  CB  . VAL   A 1 98  ? -27.82104 23.39916 4.65633   1.000 16.52951 ? 98  VAL   A CB  1 
ATOM   762  C  CG1 . VAL   A 1 98  ? -27.23037 23.85358 5.97545   1.000 16.10531 ? 98  VAL   A CG1 1 
ATOM   763  C  CG2 . VAL   A 1 98  ? -29.07867 22.54805 4.89345   1.000 11.70588 ? 98  VAL   A CG2 1 
ATOM   764  N  N   . TRP   A 1 99  ? -26.85317 26.64032 4.19914   1.000 15.17096 ? 99  TRP   A N   1 
ATOM   765  C  CA  . TRP   A 1 99  ? -25.71962 27.56091 4.09920   1.000 16.54093 ? 99  TRP   A CA  1 
ATOM   766  C  C   . TRP   A 1 99  ? -25.77798 28.53041 5.27250   1.000 17.11425 ? 99  TRP   A C   1 
ATOM   767  O  O   . TRP   A 1 99  ? -26.84219 28.76235 5.85191   1.000 17.90970 ? 99  TRP   A O   1 
ATOM   768  C  CB  . TRP   A 1 99  ? -25.72876 28.32388 2.76409   1.000 12.88230 ? 99  TRP   A CB  1 
ATOM   769  C  CG  . TRP   A 1 99  ? -24.43667 29.00023 2.35212   1.000 13.92676 ? 99  TRP   A CG  1 
ATOM   770  C  CD1 . TRP   A 1 99  ? -23.16198 28.67908 2.74743   1.000 16.02162 ? 99  TRP   A CD1 1 
ATOM   771  C  CD2 . TRP   A 1 99  ? -24.30296 30.10408 1.43490   1.000 16.98004 ? 99  TRP   A CD2 1 
ATOM   772  N  NE1 . TRP   A 1 99  ? -22.24982 29.51468 2.13323   1.000 14.36521 ? 99  TRP   A NE1 1 
ATOM   773  C  CE2 . TRP   A 1 99  ? -22.92192 30.39652 1.32525   1.000 18.23868 ? 99  TRP   A CE2 1 
ATOM   774  C  CE3 . TRP   A 1 99  ? -25.21684 30.87349 0.69597   1.000 16.65184 ? 99  TRP   A CE3 1 
ATOM   775  C  CZ2 . TRP   A 1 99  ? -22.43510 31.43905 0.51582   1.000 17.10255 ? 99  TRP   A CZ2 1 
ATOM   776  C  CZ3 . TRP   A 1 99  ? -24.72381 31.91078 -0.11610  1.000 18.66231 ? 99  TRP   A CZ3 1 
ATOM   777  C  CH2 . TRP   A 1 99  ? -23.34730 32.17621 -0.19545  1.000 16.79043 ? 99  TRP   A CH2 1 
ATOM   778  N  N   . HIS   A 1 100 ? -24.61761 29.10473 5.61097   1.000 17.44724 ? 100 HIS   A N   1 
ATOM   779  C  CA  . HIS   A 1 100 ? -24.51872 30.08583 6.68689   1.000 17.67109 ? 100 HIS   A CA  1 
ATOM   780  C  C   . HIS   A 1 100 ? -24.67518 31.52106 6.19944   1.000 19.85799 ? 100 HIS   A C   1 
ATOM   781  O  O   . HIS   A 1 100 ? -24.67013 32.44430 7.02283   1.000 21.69489 ? 100 HIS   A O   1 
ATOM   782  C  CB  . HIS   A 1 100 ? -23.18368 29.93357 7.42883   1.000 18.43973 ? 100 HIS   A CB  1 
ATOM   783  C  CG  . HIS   A 1 100 ? -21.99077 30.34810 6.61935   1.000 20.60127 ? 100 HIS   A CG  1 
ATOM   784  N  ND1 . HIS   A 1 100 ? -21.40584 29.52541 5.67949   1.000 16.43435 ? 100 HIS   A ND1 1 
ATOM   785  C  CD2 . HIS   A 1 100 ? -21.29555 31.51086 6.58779   1.000 16.88021 ? 100 HIS   A CD2 1 
ATOM   786  C  CE1 . HIS   A 1 100 ? -20.39407 30.16018 5.11093   1.000 18.51364 ? 100 HIS   A CE1 1 
ATOM   787  N  NE2 . HIS   A 1 100 ? -20.30156 31.36410 5.64938   1.000 20.83643 ? 100 HIS   A NE2 1 
ATOM   788  N  N   . SER   A 1 101 ? -24.79315 31.72944 4.88937   1.000 19.87373 ? 101 SER   A N   1 
ATOM   789  C  CA  . SER   A 1 101 ? -25.06605 33.02848 4.29333   1.000 19.22008 ? 101 SER   A CA  1 
ATOM   790  C  C   . SER   A 1 101 ? -26.39356 32.96273 3.55518   1.000 18.40727 ? 101 SER   A C   1 
ATOM   791  O  O   . SER   A 1 101 ? -26.86069 31.87954 3.19529   1.000 19.22340 ? 101 SER   A O   1 
ATOM   792  C  CB  . SER   A 1 101 ? -23.96249 33.45164 3.31180   1.000 16.62960 ? 101 SER   A CB  1 
ATOM   793  O  OG  . SER   A 1 101 ? -22.84757 33.93244 4.02073   1.000 31.46109 ? 101 SER   A OG  1 
ATOM   794  N  N   . GLN   A 1 102 ? -26.98850 34.13243 3.31432   1.000 16.37799 ? 102 GLN   A N   1 
ATOM   795  C  CA  . GLN   A 1 102 ? -28.28665 34.21932 2.64758   1.000 20.13569 ? 102 GLN   A CA  1 
ATOM   796  C  C   . GLN   A 1 102 ? -29.22412 33.14952 3.20617   1.000 20.06296 ? 102 GLN   A C   1 
ATOM   797  O  O   . GLN   A 1 102 ? -29.75663 32.28693 2.49763   1.000 14.35961 ? 102 GLN   A O   1 
ATOM   798  C  CB  . GLN   A 1 102 ? -28.12847 34.12013 1.12614   1.000 18.55728 ? 102 GLN   A CB  1 
ATOM   799  C  CG  . GLN   A 1 102 ? -27.59005 35.41932 0.48929   1.000 19.49848 ? 102 GLN   A CG  1 
ATOM   800  C  CD  . GLN   A 1 102 ? -27.14655 35.24930 -0.96439  1.000 21.42494 ? 102 GLN   A CD  1 
ATOM   801  O  OE1 . GLN   A 1 102 ? -26.03034 34.81334 -1.24048  1.000 17.44376 ? 102 GLN   A OE1 1 
ATOM   802  N  NE2 . GLN   A 1 102 ? -28.02483 35.59965 -1.89596  1.000 17.19711 ? 102 GLN   A NE2 1 
ATOM   803  N  N   . VAL   A 1 103 ? -29.35651 33.18692 4.52602   1.000 16.92128 ? 103 VAL   A N   1 
ATOM   804  C  CA  . VAL   A 1 103 ? -30.12857 32.22534 5.29700   1.000 18.21170 ? 103 VAL   A CA  1 
ATOM   805  C  C   . VAL   A 1 103 ? -30.95986 33.03471 6.28631   1.000 23.47157 ? 103 VAL   A C   1 
ATOM   806  O  O   . VAL   A 1 103 ? -30.42464 33.93214 6.95271   1.000 22.09428 ? 103 VAL   A O   1 
ATOM   807  C  CB  . VAL   A 1 103 ? -29.21143 31.20842 5.99727   1.000 23.17295 ? 103 VAL   A CB  1 
ATOM   808  C  CG1 . VAL   A 1 103 ? -28.12340 31.92496 6.82446   1.000 18.19328 ? 103 VAL   A CG1 1 
ATOM   809  C  CG2 . VAL   A 1 103 ? -30.03009 30.24423 6.85284   1.000 17.84428 ? 103 VAL   A CG2 1 
ATOM   810  N  N   . PRO   A 1 104 ? -32.26126 32.78690 6.39722   1.000 19.93771 ? 104 PRO   A N   1 
ATOM   811  C  CA  . PRO   A 1 104 ? -33.09204 33.64665 7.24907   1.000 24.54435 ? 104 PRO   A CA  1 
ATOM   812  C  C   . PRO   A 1 104 ? -32.79354 33.44334 8.72951   1.000 20.28573 ? 104 PRO   A C   1 
ATOM   813  O  O   . PRO   A 1 104 ? -32.62078 32.31845 9.20204   1.000 19.82565 ? 104 PRO   A O   1 
ATOM   814  C  CB  . PRO   A 1 104 ? -34.52333 33.23008 6.88791   1.000 16.85817 ? 104 PRO   A CB  1 
ATOM   815  C  CG  . PRO   A 1 104 ? -34.39872 31.83698 6.36445   1.000 19.67400 ? 104 PRO   A CG  1 
ATOM   816  C  CD  . PRO   A 1 104 ? -33.04726 31.75319 5.69734   1.000 18.35272 ? 104 PRO   A CD  1 
ATOM   817  N  N   . GLN   A 1 105 ? -32.73547 34.56320 9.45864   1.000 24.26247 ? 105 GLN   A N   1 
ATOM   818  C  CA  . GLN   A 1 105 ? -32.38590 34.53376 10.87771  1.000 26.21981 ? 105 GLN   A CA  1 
ATOM   819  C  C   . GLN   A 1 105 ? -33.41894 33.79427 11.73427  1.000 24.38331 ? 105 GLN   A C   1 
ATOM   820  O  O   . GLN   A 1 105 ? -33.08311 33.31594 12.82602  1.000 21.17072 ? 105 GLN   A O   1 
ATOM   821  C  CB  . GLN   A 1 105 ? -32.22417 35.96630 11.38934  1.000 30.84852 ? 105 GLN   A CB  1 
ATOM   822  C  CG  . GLN   A 1 105 ? -30.79139 36.46326 11.41897  1.000 43.79270 ? 105 GLN   A CG  1 
ATOM   823  C  CD  . GLN   A 1 105 ? -30.71631 37.97274 11.53073  1.000 58.32208 ? 105 GLN   A CD  1 
ATOM   824  O  OE1 . GLN   A 1 105 ? -29.86913 38.60663 10.89004  1.000 60.12894 ? 105 GLN   A OE1 1 
ATOM   825  N  NE2 . GLN   A 1 105 ? -31.60659 38.56296 12.34298  1.000 55.10200 ? 105 GLN   A NE2 1 
ATOM   826  N  N   . TRP   A 1 106 ? -34.67656 33.70786 11.27989  1.000 19.71107 ? 106 TRP   A N   1 
ATOM   827  C  CA  . TRP   A 1 106 ? -35.70474 33.06708 12.09995  1.000 22.61294 ? 106 TRP   A CA  1 
ATOM   828  C  C   . TRP   A 1 106 ? -35.37127 31.61429 12.39931  1.000 21.64227 ? 106 TRP   A C   1 
ATOM   829  O  O   . TRP   A 1 106 ? -35.87529 31.06943 13.38244  1.000 23.44819 ? 106 TRP   A O   1 
ATOM   830  C  CB  . TRP   A 1 106 ? -37.09548 33.16518 11.43802  1.000 17.19729 ? 106 TRP   A CB  1 
ATOM   831  C  CG  . TRP   A 1 106 ? -37.22705 32.43153 10.12734  1.000 18.60448 ? 106 TRP   A CG  1 
ATOM   832  C  CD1 . TRP   A 1 106 ? -37.16666 32.97947 8.86900   1.000 20.06537 ? 106 TRP   A CD1 1 
ATOM   833  C  CD2 . TRP   A 1 106 ? -37.43959 31.02752 9.94089   1.000 17.01366 ? 106 TRP   A CD2 1 
ATOM   834  N  NE1 . TRP   A 1 106 ? -37.32626 31.99943 7.91700   1.000 17.70360 ? 106 TRP   A NE1 1 
ATOM   835  C  CE2 . TRP   A 1 106 ? -37.48971 30.79309 8.54724   1.000 16.22357 ? 106 TRP   A CE2 1 
ATOM   836  C  CE3 . TRP   A 1 106 ? -37.60747 29.94677 10.81324  1.000 17.44556 ? 106 TRP   A CE3 1 
ATOM   837  C  CZ2 . TRP   A 1 106 ? -37.69198 29.52501 8.01231   1.000 13.64340 ? 106 TRP   A CZ2 1 
ATOM   838  C  CZ3 . TRP   A 1 106 ? -37.79322 28.68726 10.28083  1.000 18.32571 ? 106 TRP   A CZ3 1 
ATOM   839  C  CH2 . TRP   A 1 106 ? -37.83605 28.48553 8.89137   1.000 17.90988 ? 106 TRP   A CH2 1 
ATOM   840  N  N   . PHE   A 1 107 ? -34.53431 30.97446 11.57713  1.000 23.31689 ? 107 PHE   A N   1 
ATOM   841  C  CA  . PHE   A 1 107 ? -34.09769 29.60903 11.86577  1.000 21.89657 ? 107 PHE   A CA  1 
ATOM   842  C  C   . PHE   A 1 107 ? -33.51863 29.48627 13.27051  1.000 19.52530 ? 107 PHE   A C   1 
ATOM   843  O  O   . PHE   A 1 107 ? -33.70298 28.46629 13.94194  1.000 19.60885 ? 107 PHE   A O   1 
ATOM   844  C  CB  . PHE   A 1 107 ? -33.03941 29.16763 10.84486  1.000 23.27750 ? 107 PHE   A CB  1 
ATOM   845  C  CG  . PHE   A 1 107 ? -33.60172 28.47003 9.63010   1.000 23.48538 ? 107 PHE   A CG  1 
ATOM   846  C  CD1 . PHE   A 1 107 ? -34.28831 27.27191 9.75375   1.000 20.05412 ? 107 PHE   A CD1 1 
ATOM   847  C  CD2 . PHE   A 1 107 ? -33.43494 29.01530 8.36420   1.000 18.66895 ? 107 PHE   A CD2 1 
ATOM   848  C  CE1 . PHE   A 1 107 ? -34.80290 26.63524 8.63453   1.000 21.35725 ? 107 PHE   A CE1 1 
ATOM   849  C  CE2 . PHE   A 1 107 ? -33.93851 28.37950 7.24159   1.000 19.25516 ? 107 PHE   A CE2 1 
ATOM   850  C  CZ  . PHE   A 1 107 ? -34.61915 27.18967 7.37149   1.000 19.58058 ? 107 PHE   A CZ  1 
ATOM   851  N  N   . PHE   A 1 108 ? -32.78940 30.50445 13.72144  1.000 21.47891 ? 108 PHE   A N   1 
ATOM   852  C  CA  . PHE   A 1 108 ? -31.89587 30.35945 14.86593  1.000 24.27919 ? 108 PHE   A CA  1 
ATOM   853  C  C   . PHE   A 1 108 ? -32.41376 31.06148 16.12161  1.000 24.57215 ? 108 PHE   A C   1 
ATOM   854  O  O   . PHE   A 1 108 ? -31.63994 31.28488 17.05894  1.000 25.59516 ? 108 PHE   A O   1 
ATOM   855  C  CB  . PHE   A 1 108 ? -30.49789 30.87242 14.50743  1.000 17.75271 ? 108 PHE   A CB  1 
ATOM   856  C  CG  . PHE   A 1 108 ? -29.98226 30.34168 13.19990  1.000 21.95330 ? 108 PHE   A CG  1 
ATOM   857  C  CD1 . PHE   A 1 108 ? -29.75571 28.98997 13.03531  1.000 16.71317 ? 108 PHE   A CD1 1 
ATOM   858  C  CD2 . PHE   A 1 108 ? -29.75978 31.19177 12.12611  1.000 16.61551 ? 108 PHE   A CD2 1 
ATOM   859  C  CE1 . PHE   A 1 108 ? -29.30156 28.49580 11.83698  1.000 21.02605 ? 108 PHE   A CE1 1 
ATOM   860  C  CE2 . PHE   A 1 108 ? -29.30603 30.69958 10.92183  1.000 19.65070 ? 108 PHE   A CE2 1 
ATOM   861  C  CZ  . PHE   A 1 108 ? -29.07261 29.34427 10.78049  1.000 19.94251 ? 108 PHE   A CZ  1 
ATOM   862  N  N   . LEU   A 1 109 ? -33.69849 31.41167 16.15751  1.000 21.71552 ? 109 LEU   A N   1 
ATOM   863  C  CA  . LEU   A 1 109 ? -34.32323 32.02906 17.32243  1.000 26.47339 ? 109 LEU   A CA  1 
ATOM   864  C  C   . LEU   A 1 109 ? -35.06105 30.97597 18.14072  1.000 24.91111 ? 109 LEU   A C   1 
ATOM   865  O  O   . LEU   A 1 109 ? -35.72208 30.10007 17.57845  1.000 25.35930 ? 109 LEU   A O   1 
ATOM   866  C  CB  . LEU   A 1 109 ? -35.30035 33.12196 16.89626  1.000 22.94525 ? 109 LEU   A CB  1 
ATOM   867  C  CG  . LEU   A 1 109 ? -34.68851 34.28329 16.12083  1.000 25.53170 ? 109 LEU   A CG  1 
ATOM   868  C  CD1 . LEU   A 1 109 ? -35.75725 35.32228 15.84306  1.000 22.41165 ? 109 LEU   A CD1 1 
ATOM   869  C  CD2 . LEU   A 1 109 ? -33.53017 34.88689 16.89968  1.000 26.53165 ? 109 LEU   A CD2 1 
ATOM   870  N  N   . ASP   A 1 110 ? -34.95344 31.06696 19.46979  1.000 28.92225 ? 110 ASP   A N   1 
ATOM   871  C  CA  . ASP   A 1 110 ? -35.66707 30.14599 20.34960  1.000 32.68831 ? 110 ASP   A CA  1 
ATOM   872  C  C   . ASP   A 1 110 ? -37.14733 30.52980 20.43058  1.000 31.88008 ? 110 ASP   A C   1 
ATOM   873  O  O   . ASP   A 1 110 ? -37.60561 31.49036 19.79737  1.000 27.97147 ? 110 ASP   A O   1 
ATOM   874  C  CB  . ASP   A 1 110 ? -35.02236 30.09983 21.74062  1.000 34.27151 ? 110 ASP   A CB  1 
ATOM   875  C  CG  . ASP   A 1 110 ? -35.09675 31.44144 22.49963  1.000 35.78588 ? 110 ASP   A CG  1 
ATOM   876  O  OD1 . ASP   A 1 110 ? -35.95536 32.29776 22.19447  1.000 32.53329 ? 110 ASP   A OD1 1 
ATOM   877  O  OD2 . ASP   A 1 110 ? -34.27669 31.63434 23.42600  1.000 35.77457 ? 110 ASP   A OD2 1 
ATOM   878  N  N   . LYS   A 1 111 ? -37.89872 29.77916 21.24707  1.000 36.03344 ? 111 LYS   A N   1 
ATOM   879  C  CA  . LYS   A 1 111 ? -39.34784 29.95938 21.33423  1.000 34.30945 ? 111 LYS   A CA  1 
ATOM   880  C  C   . LYS   A 1 111 ? -39.74464 31.34990 21.81989  1.000 36.76375 ? 111 LYS   A C   1 
ATOM   881  O  O   . LYS   A 1 111 ? -40.84220 31.81562 21.49643  1.000 36.59617 ? 111 LYS   A O   1 
ATOM   882  C  CB  . LYS   A 1 111 ? -39.94765 28.89270 22.24407  1.000 34.16966 ? 111 LYS   A CB  1 
ATOM   883  C  CG  . LYS   A 1 111 ? -39.89610 27.48207 21.64972  1.000 40.81261 ? 111 LYS   A CG  1 
ATOM   884  C  CD  . LYS   A 1 111 ? -41.09835 27.20289 20.74215  1.000 44.65300 ? 111 LYS   A CD  1 
ATOM   885  C  CE  . LYS   A 1 111 ? -40.85185 26.02476 19.79536  1.000 47.61418 ? 111 LYS   A CE  1 
ATOM   886  N  NZ  . LYS   A 1 111 ? -41.34593 24.70449 20.30763  1.000 45.96442 ? 111 LYS   A NZ  1 
ATOM   887  N  N   . GLU   A 1 112 ? -38.87594 32.03095 22.56320  1.000 34.53386 ? 112 GLU   A N   1 
ATOM   888  C  CA  . GLU   A 1 112 ? -39.12352 33.39260 23.01441  1.000 34.19400 ? 112 GLU   A CA  1 
ATOM   889  C  C   . GLU   A 1 112 ? -38.46806 34.43461 22.12104  1.000 34.63435 ? 112 GLU   A C   1 
ATOM   890  O  O   . GLU   A 1 112 ? -38.37100 35.60134 22.51970  1.000 35.14630 ? 112 GLU   A O   1 
ATOM   891  C  CB  . GLU   A 1 112 ? -38.64084 33.57374 24.46004  1.000 38.40601 ? 112 GLU   A CB  1 
ATOM   892  C  CG  . GLU   A 1 112 ? -39.35039 32.68325 25.47767  1.000 44.21157 ? 112 GLU   A CG  1 
ATOM   893  C  CD  . GLU   A 1 112 ? -38.69587 31.31398 25.60127  1.000 54.64820 ? 112 GLU   A CD  1 
ATOM   894  O  OE1 . GLU   A 1 112 ? -39.42965 30.29827 25.67345  1.000 59.18352 ? 112 GLU   A OE1 1 
ATOM   895  O  OE2 . GLU   A 1 112 ? -37.44516 31.25321 25.61966  1.000 54.52679 ? 112 GLU   A OE2 1 
ATOM   896  N  N   . GLY   A 1 113 ? -38.00923 34.04418 20.93041  1.000 30.85602 ? 113 GLY   A N   1 
ATOM   897  C  CA  . GLY   A 1 113 ? -37.45858 34.98756 19.97789  1.000 25.02304 ? 113 GLY   A CA  1 
ATOM   898  C  C   . GLY   A 1 113 ? -36.03863 35.42444 20.25030  1.000 30.89570 ? 113 GLY   A C   1 
ATOM   899  O  O   . GLY   A 1 113 ? -35.57733 36.40011 19.64305  1.000 32.50551 ? 113 GLY   A O   1 
ATOM   900  N  N   . LYS   A 1 114 ? -35.33370 34.74424 21.14093  1.000 29.57334 ? 114 LYS   A N   1 
ATOM   901  C  CA  . LYS   A 1 114 ? -33.96899 35.09900 21.49696  1.000 34.95127 ? 114 LYS   A CA  1 
ATOM   902  C  C   . LYS   A 1 114 ? -32.98326 34.17192 20.78555  1.000 31.84273 ? 114 LYS   A C   1 
ATOM   903  O  O   . LYS   A 1 114 ? -33.29487 33.00039 20.54667  1.000 31.60181 ? 114 LYS   A O   1 
ATOM   904  C  CB  . LYS   A 1 114 ? -33.79489 35.01876 23.02250  1.000 36.12971 ? 114 LYS   A CB  1 
ATOM   905  C  CG  . LYS   A 1 114 ? -32.37362 35.20850 23.54186  1.000 46.37658 ? 114 LYS   A CG  1 
ATOM   906  C  CD  . LYS   A 1 114 ? -32.10364 36.63602 24.05019  1.000 49.22229 ? 114 LYS   A CD  1 
ATOM   907  C  CE  . LYS   A 1 114 ? -30.63082 36.79760 24.41716  1.000 34.39061 ? 114 LYS   A CE  1 
ATOM   908  N  NZ  . LYS   A 1 114 ? -30.15846 35.62086 25.21043  1.000 42.38458 ? 114 LYS   A NZ  1 
ATOM   909  N  N   . PRO   A 1 115 ? -31.80183 34.66418 20.39692  1.000 32.92801 ? 115 PRO   A N   1 
ATOM   910  C  CA  . PRO   A 1 115 ? -30.85303 33.81580 19.65450  1.000 28.90862 ? 115 PRO   A CA  1 
ATOM   911  C  C   . PRO   A 1 115 ? -30.49027 32.54893 20.41498  1.000 31.96090 ? 115 PRO   A C   1 
ATOM   912  O  O   . PRO   A 1 115 ? -30.03768 32.60282 21.56037  1.000 33.81471 ? 115 PRO   A O   1 
ATOM   913  C  CB  . PRO   A 1 115 ? -29.63337 34.72458 19.47553  1.000 31.29002 ? 115 PRO   A CB  1 
ATOM   914  C  CG  . PRO   A 1 115 ? -30.20030 36.10390 19.49066  1.000 34.40200 ? 115 PRO   A CG  1 
ATOM   915  C  CD  . PRO   A 1 115 ? -31.36163 36.07100 20.44122  1.000 30.88037 ? 115 PRO   A CD  1 
ATOM   916  N  N   . MET   A 1 116 ? -30.67401 31.40009 19.74845  1.000 29.22080 ? 116 MET   A N   1 
ATOM   917  C  CA  . MET   A 1 116 ? -30.32061 30.10982 20.34006  1.000 30.55710 ? 116 MET   A CA  1 
ATOM   918  C  C   . MET   A 1 116 ? -28.85174 30.04702 20.76483  1.000 34.24531 ? 116 MET   A C   1 
ATOM   919  O  O   . MET   A 1 116 ? -28.51800 29.32183 21.71031  1.000 30.71101 ? 116 MET   A O   1 
ATOM   920  C  CB  . MET   A 1 116 ? -30.62143 28.96694 19.35682  1.000 23.74621 ? 116 MET   A CB  1 
ATOM   921  C  CG  . MET   A 1 116 ? -32.08789 28.77925 18.95061  1.000 23.27539 ? 116 MET   A CG  1 
ATOM   922  S  SD  . MET   A 1 116 ? -32.32022 27.40806 17.77058  1.000 25.82702 ? 116 MET   A SD  1 
ATOM   923  C  CE  . MET   A 1 116 ? -34.09176 27.13552 17.82946  1.000 23.43200 ? 116 MET   A CE  1 
ATOM   924  N  N   . VAL   A 1 117 ? -27.95901 30.77327 20.07567  1.000 31.94367 ? 117 VAL   A N   1 
ATOM   925  C  CA  . VAL   A 1 117 ? -26.53239 30.69685 20.40035  1.000 28.67472 ? 117 VAL   A CA  1 
ATOM   926  C  C   . VAL   A 1 117 ? -26.25032 31.21241 21.80782  1.000 33.40590 ? 117 VAL   A C   1 
ATOM   927  O  O   . VAL   A 1 117 ? -25.26541 30.80593 22.43326  1.000 38.20746 ? 117 VAL   A O   1 
ATOM   928  C  CB  . VAL   A 1 117 ? -25.67864 31.46061 19.36334  1.000 30.30762 ? 117 VAL   A CB  1 
ATOM   929  C  CG1 . VAL   A 1 117 ? -25.67284 30.74935 18.00563  1.000 25.89409 ? 117 VAL   A CG1 1 
ATOM   930  C  CG2 . VAL   A 1 117 ? -26.14048 32.91164 19.24191  1.000 28.29428 ? 117 VAL   A CG2 1 
ATOM   931  N  N   . ASN   A 1 118 ? -27.09676 32.10210 22.33173  1.000 31.95836 ? 118 ASN   A N   1 
ATOM   932  C  CA  . ASN   A 1 118 ? -26.89177 32.67916 23.65645  1.000 35.83260 ? 118 ASN   A CA  1 
ATOM   933  C  C   . ASN   A 1 118 ? -27.28994 31.75117 24.80337  1.000 40.41776 ? 118 ASN   A C   1 
ATOM   934  O  O   . ASN   A 1 118 ? -26.94318 32.03885 25.95402  1.000 46.13780 ? 118 ASN   A O   1 
ATOM   935  C  CB  . ASN   A 1 118 ? -27.68199 33.98501 23.80169  1.000 32.67661 ? 118 ASN   A CB  1 
ATOM   936  C  CG  . ASN   A 1 118 ? -27.25603 35.04822 22.81391  1.000 32.96301 ? 118 ASN   A CG  1 
ATOM   937  O  OD1 . ASN   A 1 118 ? -28.02528 35.95831 22.50404  1.000 39.75317 ? 118 ASN   A OD1 1 
ATOM   938  N  ND2 . ASN   A 1 118 ? -26.02713 34.95421 22.32728  1.000 31.81197 ? 118 ASN   A ND2 1 
ATOM   939  N  N   . GLU   A 1 119 ? -28.00689 30.66339 24.53463  1.000 38.47260 ? 119 GLU   A N   1 
ATOM   940  C  CA  . GLU   A 1 119 ? -28.56418 29.84845 25.60709  1.000 34.96414 ? 119 GLU   A CA  1 
ATOM   941  C  C   . GLU   A 1 119 ? -27.46061 29.10824 26.35872  1.000 36.66632 ? 119 GLU   A C   1 
ATOM   942  O  O   . GLU   A 1 119 ? -26.60681 28.46424 25.74563  1.000 38.02153 ? 119 GLU   A O   1 
ATOM   943  C  CB  . GLU   A 1 119 ? -29.57419 28.86112 25.02717  1.000 32.42425 ? 119 GLU   A CB  1 
ATOM   944  C  CG  . GLU   A 1 119 ? -30.21725 27.94070 26.03547  1.000 35.68605 ? 119 GLU   A CG  1 
ATOM   945  C  CD  . GLU   A 1 119 ? -30.96278 28.69781 27.11909  1.000 46.52364 ? 119 GLU   A CD  1 
ATOM   946  O  OE1 . GLU   A 1 119 ? -31.99353 29.33627 26.80336  1.000 44.11558 ? 119 GLU   A OE1 1 
ATOM   947  O  OE2 . GLU   A 1 119 ? -30.51148 28.65748 28.28821  1.000 48.67351 ? 119 GLU   A OE2 1 
ATOM   948  N  N   . THR   A 1 120 ? -27.48602 29.19216 27.69369  1.000 41.30930 ? 120 THR   A N   1 
ATOM   949  C  CA  . THR   A 1 120 ? -26.50066 28.51838 28.53805  1.000 41.04379 ? 120 THR   A CA  1 
ATOM   950  C  C   . THR   A 1 120 ? -27.02685 27.24353 29.18811  1.000 43.59597 ? 120 THR   A C   1 
ATOM   951  O  O   . THR   A 1 120 ? -26.22459 26.36995 29.53230  1.000 42.50748 ? 120 THR   A O   1 
ATOM   952  C  CB  . THR   A 1 120 ? -25.98394 29.46564 29.63730  1.000 39.67601 ? 120 THR   A CB  1 
ATOM   953  O  OG1 . THR   A 1 120 ? -27.07429 29.91261 30.45057  1.000 44.85447 ? 120 THR   A OG1 1 
ATOM   954  C  CG2 . THR   A 1 120 ? -25.31317 30.68145 29.02719  1.000 40.19488 ? 120 THR   A CG2 1 
ATOM   955  N  N   . ASP   A 1 121 ? -28.33681 27.10380 29.34551  1.000 42.05851 ? 121 ASP   A N   1 
ATOM   956  C  CA  . ASP   A 1 121 ? -28.90305 25.90728 29.96259  1.000 39.60074 ? 121 ASP   A CA  1 
ATOM   957  C  C   . ASP   A 1 121 ? -28.74134 24.70123 29.04390  1.000 44.32187 ? 121 ASP   A C   1 
ATOM   958  O  O   . ASP   A 1 121 ? -29.20386 24.74213 27.89702  1.000 46.47106 ? 121 ASP   A O   1 
ATOM   959  C  CB  . ASP   A 1 121 ? -30.38024 26.13590 30.28338  1.000 46.23531 ? 121 ASP   A CB  1 
ATOM   960  C  CG  . ASP   A 1 121 ? -30.97927 25.01855 31.11718  1.000 43.29933 ? 121 ASP   A CG  1 
ATOM   961  O  OD1 . ASP   A 1 121 ? -30.90922 23.84277 30.70599  1.000 46.13179 ? 121 ASP   A OD1 1 
ATOM   962  O  OD2 . ASP   A 1 121 ? -31.52402 25.31464 32.19841  1.000 57.46408 ? 121 ASP   A OD2 1 
ATOM   963  N  N   . PRO   A 1 122 ? -28.12235 23.60912 29.49910  1.000 44.36495 ? 122 PRO   A N   1 
ATOM   964  C  CA  . PRO   A 1 122 ? -27.93587 22.45849 28.59998  1.000 40.87079 ? 122 PRO   A CA  1 
ATOM   965  C  C   . PRO   A 1 122 ? -29.22938 21.74770 28.22728  1.000 40.42028 ? 122 PRO   A C   1 
ATOM   966  O  O   . PRO   A 1 122 ? -29.29365 21.13796 27.15243  1.000 42.28851 ? 122 PRO   A O   1 
ATOM   967  C  CB  . PRO   A 1 122 ? -26.98473 21.53969 29.38582  1.000 37.57304 ? 122 PRO   A CB  1 
ATOM   968  C  CG  . PRO   A 1 122 ? -26.99077 22.04685 30.78152  1.000 38.27033 ? 122 PRO   A CG  1 
ATOM   969  C  CD  . PRO   A 1 122 ? -27.33267 23.49112 30.73580  1.000 42.97974 ? 122 PRO   A CD  1 
ATOM   970  N  N   . VAL   A 1 123 ? -30.25926 21.79523 29.07101  1.000 39.37693 ? 123 VAL   A N   1 
ATOM   971  C  CA  . VAL   A 1 123 ? -31.53409 21.18885 28.69960  1.000 40.65956 ? 123 VAL   A CA  1 
ATOM   972  C  C   . VAL   A 1 123 ? -32.22994 22.03479 27.63701  1.000 39.23487 ? 123 VAL   A C   1 
ATOM   973  O  O   . VAL   A 1 123 ? -32.89062 21.50765 26.73046  1.000 37.47396 ? 123 VAL   A O   1 
ATOM   974  C  CB  . VAL   A 1 123 ? -32.42043 20.99106 29.95110  1.000 48.17900 ? 123 VAL   A CB  1 
ATOM   975  C  CG1 . VAL   A 1 123 ? -33.85955 20.68131 29.55725  1.000 36.83755 ? 123 VAL   A CG1 1 
ATOM   976  C  CG2 . VAL   A 1 123 ? -31.87093 19.87451 30.85066  1.000 35.89055 ? 123 VAL   A CG2 1 
ATOM   977  N  N   . LYS   A 1 124 ? -32.09837 23.35976 27.73244  1.000 37.41088 ? 124 LYS   A N   1 
ATOM   978  C  CA  . LYS   A 1 124 ? -32.67863 24.22239 26.71464  1.000 36.06468 ? 124 LYS   A CA  1 
ATOM   979  C  C   . LYS   A 1 124 ? -31.85563 24.19028 25.43245  1.000 41.64652 ? 124 LYS   A C   1 
ATOM   980  O  O   . LYS   A 1 124 ? -32.41843 24.28840 24.33283  1.000 36.37262 ? 124 LYS   A O   1 
ATOM   981  C  CB  . LYS   A 1 124 ? -32.80001 25.65445 27.23411  1.000 36.21882 ? 124 LYS   A CB  1 
ATOM   982  C  CG  . LYS   A 1 124 ? -33.96032 25.87049 28.18407  1.000 45.46106 ? 124 LYS   A CG  1 
ATOM   983  C  CD  . LYS   A 1 124 ? -33.74091 27.09107 29.08006  1.000 52.71490 ? 124 LYS   A CD  1 
ATOM   984  C  CE  . LYS   A 1 124 ? -34.99877 27.95383 29.16157  1.000 56.82158 ? 124 LYS   A CE  1 
ATOM   985  N  NZ  . LYS   A 1 124 ? -35.22296 28.50277 30.53263  1.000 61.57911 ? 124 LYS   A NZ  1 
ATOM   986  N  N   . ARG   A 1 125 ? -30.53015 24.05483 25.54938  1.000 35.79011 ? 125 ARG   A N   1 
ATOM   987  C  CA  . ARG   A 1 125 ? -29.71006 23.90950 24.35363  1.000 34.85170 ? 125 ARG   A CA  1 
ATOM   988  C  C   . ARG   A 1 125 ? -30.12918 22.68338 23.56073  1.000 35.18563 ? 125 ARG   A C   1 
ATOM   989  O  O   . ARG   A 1 125 ? -30.22373 22.73684 22.32968  1.000 35.17519 ? 125 ARG   A O   1 
ATOM   990  C  CB  . ARG   A 1 125 ? -28.22996 23.83311 24.72262  1.000 31.95053 ? 125 ARG   A CB  1 
ATOM   991  C  CG  . ARG   A 1 125 ? -27.63457 25.18347 25.10713  1.000 37.57264 ? 125 ARG   A CG  1 
ATOM   992  C  CD  . ARG   A 1 125 ? -26.11745 25.13870 25.16308  1.000 36.04517 ? 125 ARG   A CD  1 
ATOM   993  N  NE  . ARG   A 1 125 ? -25.54260 24.99251 23.83197  1.000 39.00852 ? 125 ARG   A NE  1 
ATOM   994  C  CZ  . ARG   A 1 125 ? -25.39417 25.99396 22.96881  1.000 38.00146 ? 125 ARG   A CZ  1 
ATOM   995  N  NH1 . ARG   A 1 125 ? -25.77260 27.22591 23.29400  1.000 31.88611 ? 125 ARG   A NH1 1 
ATOM   996  N  NH2 . ARG   A 1 125 ? -24.85875 25.76276 21.77697  1.000 39.59934 ? 125 ARG   A NH2 1 
ATOM   997  N  N   . GLU   A 1 126 ? -30.40886 21.57300 24.24631  1.000 33.60787 ? 126 GLU   A N   1 
ATOM   998  C  CA  . GLU   A 1 126 ? -30.80530 20.37479 23.52057  1.000 33.56019 ? 126 GLU   A CA  1 
ATOM   999  C  C   . GLU   A 1 126 ? -32.16971 20.56131 22.87220  1.000 36.66382 ? 126 GLU   A C   1 
ATOM   1000 O  O   . GLU   A 1 126 ? -32.40254 20.08608 21.75266  1.000 33.11254 ? 126 GLU   A O   1 
ATOM   1001 C  CB  . GLU   A 1 126 ? -30.80040 19.15952 24.44291  1.000 27.37726 ? 126 GLU   A CB  1 
ATOM   1002 C  CG  . GLU   A 1 126 ? -31.22043 17.86724 23.75230  1.000 28.40502 ? 126 GLU   A CG  1 
ATOM   1003 C  CD  . GLU   A 1 126 ? -30.27475 17.45576 22.62992  1.000 35.89455 ? 126 GLU   A CD  1 
ATOM   1004 O  OE1 . GLU   A 1 126 ? -29.08732 17.85253 22.65802  1.000 38.45267 ? 126 GLU   A OE1 1 
ATOM   1005 O  OE2 . GLU   A 1 126 ? -30.71962 16.72658 21.71499  1.000 38.47084 ? 126 GLU   A OE2 1 
ATOM   1006 N  N   . GLN   A 1 127 ? -33.07622 21.26866 23.54896  1.000 30.04707 ? 127 GLN   A N   1 
ATOM   1007 C  CA  . GLN   A 1 127 ? -34.36061 21.57760 22.93598  1.000 35.17015 ? 127 GLN   A CA  1 
ATOM   1008 C  C   . GLN   A 1 127 ? -34.19231 22.47514 21.71512  1.000 31.16149 ? 127 GLN   A C   1 
ATOM   1009 O  O   . GLN   A 1 127 ? -34.94446 22.34590 20.74081  1.000 29.47217 ? 127 GLN   A O   1 
ATOM   1010 C  CB  . GLN   A 1 127 ? -35.28882 22.23250 23.96029  1.000 33.25750 ? 127 GLN   A CB  1 
ATOM   1011 C  CG  . GLN   A 1 127 ? -35.69315 21.31060 25.09838  1.000 36.39922 ? 127 GLN   A CG  1 
ATOM   1012 C  CD  . GLN   A 1 127 ? -36.38411 22.04582 26.24000  1.000 41.17443 ? 127 GLN   A CD  1 
ATOM   1013 O  OE1 . GLN   A 1 127 ? -36.32576 23.27548 26.33867  1.000 40.15577 ? 127 GLN   A OE1 1 
ATOM   1014 N  NE2 . GLN   A 1 127 ? -37.04187 21.28911 27.11085  1.000 39.67943 ? 127 GLN   A NE2 1 
ATOM   1015 N  N   . ASN   A 1 128 ? -33.21687 23.38379 21.74216  1.000 29.98285 ? 128 ASN   A N   1 
ATOM   1016 C  CA  . ASN   A 1 128 ? -33.00347 24.24128 20.58345  1.000 31.26311 ? 128 ASN   A CA  1 
ATOM   1017 C  C   . ASN   A 1 128 ? -32.43875 23.44720 19.41405  1.000 28.17592 ? 128 ASN   A C   1 
ATOM   1018 O  O   . ASN   A 1 128 ? -32.87546 23.62181 18.27154  1.000 27.65372 ? 128 ASN   A O   1 
ATOM   1019 C  CB  . ASN   A 1 128 ? -32.09222 25.40328 20.95521  1.000 25.90237 ? 128 ASN   A CB  1 
ATOM   1020 C  CG  . ASN   A 1 128 ? -32.81215 26.43841 21.77726  1.000 28.50913 ? 128 ASN   A CG  1 
ATOM   1021 O  OD1 . ASN   A 1 128 ? -34.02932 26.54075 21.70487  1.000 30.18953 ? 128 ASN   A OD1 1 
ATOM   1022 N  ND2 . ASN   A 1 128 ? -32.06977 27.21118 22.56924  1.000 30.04155 ? 128 ASN   A ND2 1 
ATOM   1023 N  N   . LYS   A 1 129 ? -31.48413 22.55863 19.68403  1.000 24.88524 ? 129 LYS   A N   1 
ATOM   1024 C  CA  . LYS   A 1 129 ? -30.98371 21.66652 18.64688  1.000 27.24829 ? 129 LYS   A CA  1 
ATOM   1025 C  C   . LYS   A 1 129 ? -32.12918 20.92992 17.96270  1.000 28.31531 ? 129 LYS   A C   1 
ATOM   1026 O  O   . LYS   A 1 129 ? -32.22094 20.89944 16.73140  1.000 27.37615 ? 129 LYS   A O   1 
ATOM   1027 C  CB  . LYS   A 1 129 ? -29.98243 20.67685 19.24802  1.000 25.02740 ? 129 LYS   A CB  1 
ATOM   1028 C  CG  . LYS   A 1 129 ? -29.47323 19.64609 18.26321  1.000 27.92707 ? 129 LYS   A CG  1 
ATOM   1029 C  CD  . LYS   A 1 129 ? -28.52875 18.65547 18.91936  1.000 25.31083 ? 129 LYS   A CD  1 
ATOM   1030 C  CE  . LYS   A 1 129 ? -28.24220 17.50494 17.97862  1.000 29.92404 ? 129 LYS   A CE  1 
ATOM   1031 N  NZ  . LYS   A 1 129 ? -27.21525 16.55307 18.48530  1.000 24.36413 ? 129 LYS   A NZ  1 
ATOM   1032 N  N   . GLN   A 1 130 ? -33.03368 20.35018 18.74936  1.000 29.76674 ? 130 GLN   A N   1 
ATOM   1033 C  CA  . GLN   A 1 130 ? -34.12951 19.59655 18.15493  1.000 27.30106 ? 130 GLN   A CA  1 
ATOM   1034 C  C   . GLN   A 1 130 ? -35.07965 20.50662 17.37380  1.000 26.52082 ? 130 GLN   A C   1 
ATOM   1035 O  O   . GLN   A 1 130 ? -35.56953 20.12668 16.30491  1.000 26.40589 ? 130 GLN   A O   1 
ATOM   1036 C  CB  . GLN   A 1 130 ? -34.86918 18.81754 19.24828  1.000 34.26460 ? 130 GLN   A CB  1 
ATOM   1037 C  CG  . GLN   A 1 130 ? -33.99875 17.76538 19.93869  1.000 30.77613 ? 130 GLN   A CG  1 
ATOM   1038 C  CD  . GLN   A 1 130 ? -33.39388 16.76147 18.96152  1.000 32.60464 ? 130 GLN   A CD  1 
ATOM   1039 O  OE1 . GLN   A 1 130 ? -34.01460 16.40547 17.96091  1.000 38.28283 ? 130 GLN   A OE1 1 
ATOM   1040 N  NE2 . GLN   A 1 130 ? -32.17973 16.29771 19.25308  1.000 29.63436 ? 130 GLN   A NE2 1 
ATOM   1041 N  N   . LEU   A 1 131 ? -35.35831 21.70753 17.88601  1.000 24.45781 ? 131 LEU   A N   1 
ATOM   1042 C  CA  . LEU   A 1 131 ? -36.20960 22.63924 17.15138  1.000 23.38031 ? 131 LEU   A CA  1 
ATOM   1043 C  C   . LEU   A 1 131 ? -35.55832 23.05955 15.83388  1.000 26.07296 ? 131 LEU   A C   1 
ATOM   1044 O  O   . LEU   A 1 131 ? -36.21334 23.09489 14.78434  1.000 23.36815 ? 131 LEU   A O   1 
ATOM   1045 C  CB  . LEU   A 1 131 ? -36.52101 23.86200 18.01514  1.000 21.30536 ? 131 LEU   A CB  1 
ATOM   1046 C  CG  . LEU   A 1 131 ? -37.43481 24.92188 17.39521  1.000 23.85610 ? 131 LEU   A CG  1 
ATOM   1047 C  CD1 . LEU   A 1 131 ? -38.79576 24.33661 17.00413  1.000 20.66176 ? 131 LEU   A CD1 1 
ATOM   1048 C  CD2 . LEU   A 1 131 ? -37.59092 26.14806 18.31151  1.000 26.71113 ? 131 LEU   A CD2 1 
ATOM   1049 N  N   . LEU   A 1 132 ? -34.26283 23.38231 15.86752  1.000 25.67965 ? 132 LEU   A N   1 
ATOM   1050 C  CA  . LEU   A 1 132 ? -33.57541 23.75339 14.63468  1.000 23.88553 ? 132 LEU   A CA  1 
ATOM   1051 C  C   . LEU   A 1 132 ? -33.57737 22.60132 13.63469  1.000 24.33350 ? 132 LEU   A C   1 
ATOM   1052 O  O   . LEU   A 1 132 ? -33.80773 22.80721 12.43638  1.000 20.80415 ? 132 LEU   A O   1 
ATOM   1053 C  CB  . LEU   A 1 132 ? -32.14634 24.19840 14.94196  1.000 20.40186 ? 132 LEU   A CB  1 
ATOM   1054 C  CG  . LEU   A 1 132 ? -31.31211 24.64797 13.73738  1.000 20.45271 ? 132 LEU   A CG  1 
ATOM   1055 C  CD1 . LEU   A 1 132 ? -31.94355 25.84405 13.00739  1.000 13.11990 ? 132 LEU   A CD1 1 
ATOM   1056 C  CD2 . LEU   A 1 132 ? -29.88479 24.94998 14.17244  1.000 19.17525 ? 132 LEU   A CD2 1 
ATOM   1057 N  N   . LEU   A 1 133 ? -33.32782 21.37915 14.11125  1.000 21.71194 ? 133 LEU   A N   1 
ATOM   1058 C  CA  . LEU   A 1 133 ? -33.27720 20.23645 13.21261  1.000 19.46704 ? 133 LEU   A CA  1 
ATOM   1059 C  C   . LEU   A 1 133 ? -34.64254 19.93530 12.60613  1.000 26.98447 ? 133 LEU   A C   1 
ATOM   1060 O  O   . LEU   A 1 133 ? -34.71398 19.43372 11.48135  1.000 24.53069 ? 133 LEU   A O   1 
ATOM   1061 C  CB  . LEU   A 1 133 ? -32.72727 19.01896 13.94923  1.000 19.19498 ? 133 LEU   A CB  1 
ATOM   1062 C  CG  . LEU   A 1 133 ? -31.24420 19.15898 14.31563  1.000 24.22252 ? 133 LEU   A CG  1 
ATOM   1063 C  CD1 . LEU   A 1 133 ? -30.73110 17.91649 15.02973  1.000 19.44738 ? 133 LEU   A CD1 1 
ATOM   1064 C  CD2 . LEU   A 1 133 ? -30.40167 19.47188 13.06372  1.000 17.24828 ? 133 LEU   A CD2 1 
ATOM   1065 N  N   . LYS   A 1 134 ? -35.73274 20.23394 13.32343  1.000 25.87100 ? 134 LYS   A N   1 
ATOM   1066 C  CA  . LYS   A 1 134 ? -37.06250 20.06343 12.74783  1.000 24.63212 ? 134 LYS   A CA  1 
ATOM   1067 C  C   . LYS   A 1 134 ? -37.32620 21.11055 11.67187  1.000 22.08671 ? 134 LYS   A C   1 
ATOM   1068 O  O   . LYS   A 1 134 ? -37.81559 20.78967 10.58226  1.000 22.52048 ? 134 LYS   A O   1 
ATOM   1069 C  CB  . LYS   A 1 134 ? -38.13148 20.13168 13.84384  1.000 25.00326 ? 134 LYS   A CB  1 
ATOM   1070 C  CG  . LYS   A 1 134 ? -39.41719 19.41242 13.46596  1.000 26.64225 ? 134 LYS   A CG  1 
ATOM   1071 C  CD  . LYS   A 1 134 ? -40.67113 20.06921 14.07726  1.000 42.84976 ? 134 LYS   A CD  1 
ATOM   1072 C  CE  . LYS   A 1 134 ? -40.44979 20.52484 15.51998  1.000 41.04714 ? 134 LYS   A CE  1 
ATOM   1073 N  NZ  . LYS   A 1 134 ? -41.29776 21.71863 15.87498  1.000 40.89351 ? 134 LYS   A NZ  1 
ATOM   1074 N  N   . ARG   A 1 135 ? -36.99890 22.37062 11.95910  1.000 20.15727 ? 135 ARG   A N   1 
ATOM   1075 C  CA  . ARG   A 1 135 ? -37.10063 23.41109 10.94176  1.000 20.54302 ? 135 ARG   A CA  1 
ATOM   1076 C  C   . ARG   A 1 135 ? -36.30024 23.05199 9.69326   1.000 21.60465 ? 135 ARG   A C   1 
ATOM   1077 O  O   . ARG   A 1 135 ? -36.78474 23.21975 8.56493   1.000 19.28679 ? 135 ARG   A O   1 
ATOM   1078 C  CB  . ARG   A 1 135 ? -36.62521 24.73925 11.52185  1.000 20.92942 ? 135 ARG   A CB  1 
ATOM   1079 C  CG  . ARG   A 1 135 ? -37.55694 25.29291 12.58031  1.000 22.20192 ? 135 ARG   A CG  1 
ATOM   1080 C  CD  . ARG   A 1 135 ? -36.89326 26.37447 13.40241  1.000 21.15471 ? 135 ARG   A CD  1 
ATOM   1081 N  NE  . ARG   A 1 135 ? -37.88558 27.08795 14.18795  1.000 21.68671 ? 135 ARG   A NE  1 
ATOM   1082 C  CZ  . ARG   A 1 135 ? -37.60389 28.01345 15.09778  1.000 26.26204 ? 135 ARG   A CZ  1 
ATOM   1083 N  NH1 . ARG   A 1 135 ? -36.34453 28.33889 15.34784  1.000 21.79088 ? 135 ARG   A NH1 1 
ATOM   1084 N  NH2 . ARG   A 1 135 ? -38.58926 28.60747 15.76435  1.000 25.92759 ? 135 ARG   A NH2 1 
ATOM   1085 N  N   . LEU   A 1 136 ? -35.07163 22.56368 9.88008   1.000 16.51071 ? 136 LEU   A N   1 
ATOM   1086 C  CA  . LEU   A 1 136 ? -34.24549 22.13549 8.76079   1.000 17.82375 ? 136 LEU   A CA  1 
ATOM   1087 C  C   . LEU   A 1 136 ? -34.97258 21.11544 7.90642   1.000 19.85144 ? 136 LEU   A C   1 
ATOM   1088 O  O   . LEU   A 1 136 ? -35.06322 21.26176 6.68011   1.000 17.09787 ? 136 LEU   A O   1 
ATOM   1089 C  CB  . LEU   A 1 136 ? -32.93210 21.54731 9.27575   1.000 16.14876 ? 136 LEU   A CB  1 
ATOM   1090 C  CG  . LEU   A 1 136 ? -31.95539 21.00741 8.22397   1.000 17.66682 ? 136 LEU   A CG  1 
ATOM   1091 C  CD1 . LEU   A 1 136 ? -31.70208 22.05593 7.15004   1.000 11.24106 ? 136 LEU   A CD1 1 
ATOM   1092 C  CD2 . LEU   A 1 136 ? -30.64367 20.59286 8.88936   1.000 13.86219 ? 136 LEU   A CD2 1 
ATOM   1093 N  N   . GLU   A 1 137 ? -35.49827 20.07106 8.54811   1.000 15.79387 ? 137 GLU   A N   1 
ATOM   1094 C  CA  . GLU   A 1 137 ? -36.15166 18.99177 7.81863   1.000 18.01592 ? 137 GLU   A CA  1 
ATOM   1095 C  C   . GLU   A 1 137 ? -37.37645 19.49103 7.05499   1.000 17.30696 ? 137 GLU   A C   1 
ATOM   1096 O  O   . GLU   A 1 137 ? -37.63463 19.05277 5.92290   1.000 17.02609 ? 137 GLU   A O   1 
ATOM   1097 C  CB  . GLU   A 1 137 ? -36.53524 17.87278 8.79688   1.000 20.62076 ? 137 GLU   A CB  1 
ATOM   1098 C  CG  . GLU   A 1 137 ? -37.37910 16.75312 8.18525   1.000 26.99282 ? 137 GLU   A CG  1 
ATOM   1099 C  CD  . GLU   A 1 137 ? -37.20117 15.40818 8.88859   1.000 44.81655 ? 137 GLU   A CD  1 
ATOM   1100 O  OE1 . GLU   A 1 137 ? -37.95006 14.45686 8.54867   1.000 45.79212 ? 137 GLU   A OE1 1 
ATOM   1101 O  OE2 . GLU   A 1 137 ? -36.30906 15.29794 9.76850   1.000 51.33304 ? 137 GLU   A OE2 1 
ATOM   1102 N  N   . THR   A 1 138 ? -38.14186 20.40630 7.65785   1.000 13.61352 ? 138 THR   A N   1 
ATOM   1103 C  CA  . THR   A 1 138 ? -39.33767 20.93108 7.00453   1.000 15.43272 ? 138 THR   A CA  1 
ATOM   1104 C  C   . THR   A 1 138 ? -38.97180 21.77767 5.78648   1.000 15.52187 ? 138 THR   A C   1 
ATOM   1105 O  O   . THR   A 1 138 ? -39.62386 21.68969 4.73565   1.000 13.70816 ? 138 THR   A O   1 
ATOM   1106 C  CB  . THR   A 1 138 ? -40.15688 21.75194 8.00707   1.000 15.61567 ? 138 THR   A CB  1 
ATOM   1107 O  OG1 . THR   A 1 138 ? -40.66727 20.89101 9.03512   1.000 19.14933 ? 138 THR   A OG1 1 
ATOM   1108 C  CG2 . THR   A 1 138 ? -41.31777 22.46453 7.31737   1.000 12.02796 ? 138 THR   A CG2 1 
ATOM   1109 N  N   . HIS   A 1 139 ? -37.93620 22.61037 5.91729   1.000 16.53271 ? 139 HIS   A N   1 
ATOM   1110 C  CA  . HIS   A 1 139 ? -37.42972 23.37645 4.78034   1.000 15.42084 ? 139 HIS   A CA  1 
ATOM   1111 C  C   . HIS   A 1 139 ? -37.05237 22.44875 3.63343   1.000 15.18080 ? 139 HIS   A C   1 
ATOM   1112 O  O   . HIS   A 1 139 ? -37.52842 22.61335 2.50522   1.000 14.33301 ? 139 HIS   A O   1 
ATOM   1113 C  CB  . HIS   A 1 139 ? -36.23396 24.21927 5.23714   1.000 13.36166 ? 139 HIS   A CB  1 
ATOM   1114 C  CG  . HIS   A 1 139 ? -35.61591 25.07320 4.16760   1.000 14.78747 ? 139 HIS   A CG  1 
ATOM   1115 N  ND1 . HIS   A 1 139 ? -36.12182 26.30441 3.80698   1.000 13.09610 ? 139 HIS   A ND1 1 
ATOM   1116 C  CD2 . HIS   A 1 139 ? -34.49608 24.89490 3.42312   1.000 12.84779 ? 139 HIS   A CD2 1 
ATOM   1117 C  CE1 . HIS   A 1 139 ? -35.35611 26.83669 2.87022   1.000 15.64373 ? 139 HIS   A CE1 1 
ATOM   1118 N  NE2 . HIS   A 1 139 ? -34.35958 26.00290 2.62167   1.000 16.22020 ? 139 HIS   A NE2 1 
ATOM   1119 N  N   . ILE   A 1 140 ? -36.25191 21.42244 3.92631   1.000 14.53775 ? 140 ILE   A N   1 
ATOM   1120 C  CA  . ILE   A 1 140 ? -35.78606 20.50921 2.88761   1.000 13.88916 ? 140 ILE   A CA  1 
ATOM   1121 C  C   . ILE   A 1 140 ? -36.95004 19.71243 2.31431   1.000 18.55274 ? 140 ILE   A C   1 
ATOM   1122 O  O   . ILE   A 1 140 ? -37.03240 19.49508 1.09535   1.000 15.02626 ? 140 ILE   A O   1 
ATOM   1123 C  CB  . ILE   A 1 140 ? -34.67284 19.60327 3.45545   1.000 15.73683 ? 140 ILE   A CB  1 
ATOM   1124 C  CG1 . ILE   A 1 140 ? -33.43080 20.45013 3.75374   1.000 15.52530 ? 140 ILE   A CG1 1 
ATOM   1125 C  CG2 . ILE   A 1 140 ? -34.32937 18.42444 2.50457   1.000 10.94698 ? 140 ILE   A CG2 1 
ATOM   1126 C  CD1 . ILE   A 1 140 ? -32.26981 19.66891 4.31386   1.000 13.53559 ? 140 ILE   A CD1 1 
ATOM   1127 N  N   . LYS   A 1 141 ? -37.87866 19.28739 3.18006   1.000 20.00721 ? 141 LYS   A N   1 
ATOM   1128 C  CA  . LYS   A 1 141 ? -38.99637 18.46103 2.73925   1.000 15.64882 ? 141 LYS   A CA  1 
ATOM   1129 C  C   . LYS   A 1 141 ? -39.86290 19.21757 1.75332   1.000 13.58786 ? 141 LYS   A C   1 
ATOM   1130 O  O   . LYS   A 1 141 ? -40.23203 18.68946 0.70528   1.000 16.70251 ? 141 LYS   A O   1 
ATOM   1131 C  CB  . LYS   A 1 141 ? -39.82084 18.00830 3.94984   1.000 19.81242 ? 141 LYS   A CB  1 
ATOM   1132 C  CG  . LYS   A 1 141 ? -41.14519 17.30706 3.64244   1.000 14.98671 ? 141 LYS   A CG  1 
ATOM   1133 C  CD  . LYS   A 1 141 ? -41.93102 17.08507 4.95202   1.000 16.86748 ? 141 LYS   A CD  1 
ATOM   1134 C  CE  . LYS   A 1 141 ? -43.27873 16.43123 4.70546   1.000 16.07572 ? 141 LYS   A CE  1 
ATOM   1135 N  NZ  . LYS   A 1 141 ? -44.29161 17.37695 4.14233   1.000 12.30717 ? 141 LYS   A NZ  1 
ATOM   1136 N  N   . THR   A 1 142 ? -40.18004 20.47106 2.06759   1.000 16.39723 ? 142 THR   A N   1 
ATOM   1137 C  CA  . THR   A 1 142 ? -41.04705 21.24979 1.19332   1.000 15.75229 ? 142 THR   A CA  1 
ATOM   1138 C  C   . THR   A 1 142 ? -40.40057 21.44911 -0.17169  1.000 17.36536 ? 142 THR   A C   1 
ATOM   1139 O  O   . THR   A 1 142 ? -41.05857 21.28605 -1.20672  1.000 13.12093 ? 142 THR   A O   1 
ATOM   1140 C  CB  . THR   A 1 142 ? -41.37391 22.59146 1.85212   1.000 18.60395 ? 142 THR   A CB  1 
ATOM   1141 O  OG1 . THR   A 1 142 ? -41.85027 22.36735 3.19023   1.000 17.23790 ? 142 THR   A OG1 1 
ATOM   1142 C  CG2 . THR   A 1 142 ? -42.43503 23.32605 1.07752   1.000 12.22158 ? 142 THR   A CG2 1 
ATOM   1143 N  N   . ILE   A 1 143 ? -39.10157 21.76087 -0.19232  1.000 16.34412 ? 143 ILE   A N   1 
ATOM   1144 C  CA  . ILE   A 1 143 ? -38.40848 22.00617 -1.45651  1.000 16.15019 ? 143 ILE   A CA  1 
ATOM   1145 C  C   . ILE   A 1 143 ? -38.31273 20.72640 -2.27662  1.000 14.69713 ? 143 ILE   A C   1 
ATOM   1146 O  O   . ILE   A 1 143 ? -38.57486 20.72051 -3.48373  1.000 17.80061 ? 143 ILE   A O   1 
ATOM   1147 C  CB  . ILE   A 1 143 ? -37.01332 22.60073 -1.20198  1.000 14.01632 ? 143 ILE   A CB  1 
ATOM   1148 C  CG1 . ILE   A 1 143 ? -37.13099 24.01552 -0.62888  1.000 13.95062 ? 143 ILE   A CG1 1 
ATOM   1149 C  CG2 . ILE   A 1 143 ? -36.16894 22.56604 -2.50013  1.000 11.18505 ? 143 ILE   A CG2 1 
ATOM   1150 C  CD1 . ILE   A 1 143 ? -35.86195 24.47928 0.07511   1.000 12.38752 ? 143 ILE   A CD1 1 
ATOM   1151 N  N   . VAL   A 1 144 ? -37.93006 19.62486 -1.63595  1.000 16.87323 ? 144 VAL   A N   1 
ATOM   1152 C  CA  . VAL   A 1 144 ? -37.63431 18.41603 -2.38442  1.000 13.95571 ? 144 VAL   A CA  1 
ATOM   1153 C  C   . VAL   A 1 144 ? -38.92068 17.76917 -2.87810  1.000 21.17059 ? 144 VAL   A C   1 
ATOM   1154 O  O   . VAL   A 1 144 ? -38.98153 17.23797 -3.99762  1.000 17.67973 ? 144 VAL   A O   1 
ATOM   1155 C  CB  . VAL   A 1 144 ? -36.79725 17.46591 -1.51489  1.000 19.14992 ? 144 VAL   A CB  1 
ATOM   1156 C  CG1 . VAL   A 1 144 ? -36.66315 16.14520 -2.19717  1.000 19.62084 ? 144 VAL   A CG1 1 
ATOM   1157 C  CG2 . VAL   A 1 144 ? -35.41207 18.05896 -1.28254  1.000 16.55781 ? 144 VAL   A CG2 1 
ATOM   1158 N  N   . GLU   A 1 145 ? -39.97731 17.82296 -2.06563  1.000 13.63699 ? 145 GLU   A N   1 
ATOM   1159 C  CA  . GLU   A 1 145 ? -41.26338 17.31574 -2.51771  1.000 17.81245 ? 145 GLU   A CA  1 
ATOM   1160 C  C   . GLU   A 1 145 ? -41.72724 18.04445 -3.77403  1.000 15.78595 ? 145 GLU   A C   1 
ATOM   1161 O  O   . GLU   A 1 145 ? -42.38868 17.44608 -4.62595  1.000 16.09652 ? 145 GLU   A O   1 
ATOM   1162 C  CB  . GLU   A 1 145 ? -42.30082 17.42267 -1.37792  1.000 13.28309 ? 145 GLU   A CB  1 
ATOM   1163 C  CG  . GLU   A 1 145 ? -42.15180 16.30088 -0.32052  1.000 15.01442 ? 145 GLU   A CG  1 
ATOM   1164 C  CD  . GLU   A 1 145 ? -43.10923 16.40674 0.86969   1.000 17.28610 ? 145 GLU   A CD  1 
ATOM   1165 O  OE1 . GLU   A 1 145 ? -43.42234 17.52982 1.31686   1.000 19.51232 ? 145 GLU   A OE1 1 
ATOM   1166 O  OE2 . GLU   A 1 145 ? -43.54726 15.34980 1.37691   1.000 16.55938 ? 145 GLU   A OE2 1 
ATOM   1167 N  N   . ARG   A 1 146 ? -41.37616 19.32312 -3.92518  1.000 13.73348 ? 146 ARG   A N   1 
ATOM   1168 C  CA  . ARG   A 1 146 ? -41.80529 20.05174 -5.11700  1.000 15.19593 ? 146 ARG   A CA  1 
ATOM   1169 C  C   . ARG   A 1 146 ? -40.95270 19.72145 -6.34880  1.000 14.67786 ? 146 ARG   A C   1 
ATOM   1170 O  O   . ARG   A 1 146 ? -41.48611 19.59537 -7.45780  1.000 14.68180 ? 146 ARG   A O   1 
ATOM   1171 C  CB  . ARG   A 1 146 ? -41.77649 21.55095 -4.84564  1.000 13.42683 ? 146 ARG   A CB  1 
ATOM   1172 C  CG  . ARG   A 1 146 ? -42.30900 22.39251 -5.99543  1.000 12.82358 ? 146 ARG   A CG  1 
ATOM   1173 C  CD  . ARG   A 1 146 ? -42.26307 23.85947 -5.61625  1.000 14.71160 ? 146 ARG   A CD  1 
ATOM   1174 N  NE  . ARG   A 1 146 ? -42.88908 24.74387 -6.59951  1.000 15.94452 ? 146 ARG   A NE  1 
ATOM   1175 C  CZ  . ARG   A 1 146 ? -44.19909 24.96307 -6.71115  1.000 14.93681 ? 146 ARG   A CZ  1 
ATOM   1176 N  NH1 . ARG   A 1 146 ? -45.06380 24.35294 -5.91026  1.000 14.90385 ? 146 ARG   A NH1 1 
ATOM   1177 N  NH2 . ARG   A 1 146 ? -44.65207 25.79559 -7.63542  1.000 16.63319 ? 146 ARG   A NH2 1 
ATOM   1178 N  N   . TYR   A 1 147 ? -39.63839 19.56218 -6.18124  1.000 13.42090 ? 147 TYR   A N   1 
ATOM   1179 C  CA  . TYR   A 1 147 ? -38.70036 19.52788 -7.30526  1.000 14.02139 ? 147 TYR   A CA  1 
ATOM   1180 C  C   . TYR   A 1 147 ? -38.05512 18.16940 -7.56472  1.000 16.29898 ? 147 TYR   A C   1 
ATOM   1181 O  O   . TYR   A 1 147 ? -37.21567 18.07840 -8.46223  1.000 15.01656 ? 147 TYR   A O   1 
ATOM   1182 C  CB  . TYR   A 1 147 ? -37.58533 20.56092 -7.08343  1.000 11.72895 ? 147 TYR   A CB  1 
ATOM   1183 C  CG  . TYR   A 1 147 ? -38.05679 21.99928 -7.15501  1.000 15.80828 ? 147 TYR   A CG  1 
ATOM   1184 C  CD1 . TYR   A 1 147 ? -38.86356 22.43284 -8.19624  1.000 14.54491 ? 147 TYR   A CD1 1 
ATOM   1185 C  CD2 . TYR   A 1 147 ? -37.69680 22.91426 -6.18611  1.000 13.00822 ? 147 TYR   A CD2 1 
ATOM   1186 C  CE1 . TYR   A 1 147 ? -39.28658 23.72986 -8.27422  1.000 15.27042 ? 147 TYR   A CE1 1 
ATOM   1187 C  CE2 . TYR   A 1 147 ? -38.11526 24.22113 -6.25412  1.000 15.88190 ? 147 TYR   A CE2 1 
ATOM   1188 C  CZ  . TYR   A 1 147 ? -38.91453 24.62605 -7.29984  1.000 17.64547 ? 147 TYR   A CZ  1 
ATOM   1189 O  OH  . TYR   A 1 147 ? -39.34254 25.93455 -7.38183  1.000 14.93702 ? 147 TYR   A OH  1 
ATOM   1190 N  N   . LYS   A 1 148 ? -38.41584 17.11469 -6.81734  1.000 17.07474 ? 148 LYS   A N   1 
ATOM   1191 C  CA  . LYS   A 1 148 ? -37.67872 15.84839 -6.90007  1.000 19.39585 ? 148 LYS   A CA  1 
ATOM   1192 C  C   . LYS   A 1 148 ? -37.72553 15.22690 -8.29235  1.000 17.77470 ? 148 LYS   A C   1 
ATOM   1193 O  O   . LYS   A 1 148 ? -36.80218 14.49753 -8.67224  1.000 19.59785 ? 148 LYS   A O   1 
ATOM   1194 C  CB  . LYS   A 1 148 ? -38.20935 14.84074 -5.87069  1.000 20.28382 ? 148 LYS   A CB  1 
ATOM   1195 C  CG  . LYS   A 1 148 ? -39.68722 14.47496 -6.04671  1.000 21.23418 ? 148 LYS   A CG  1 
ATOM   1196 C  CD  . LYS   A 1 148 ? -40.13674 13.43634 -5.03063  1.000 20.90500 ? 148 LYS   A CD  1 
ATOM   1197 C  CE  . LYS   A 1 148 ? -41.36849 12.69520 -5.52437  1.000 34.60769 ? 148 LYS   A CE  1 
ATOM   1198 N  NZ  . LYS   A 1 148 ? -40.96961 11.42378 -6.23542  1.000 45.87588 ? 148 LYS   A NZ  1 
ATOM   1199 N  N   . ASP   A 1 149 ? -38.78032 15.47953 -9.06227  1.000 18.23338 ? 149 ASP   A N   1 
ATOM   1200 C  CA  . ASP   A 1 149 ? -38.86976 14.89010 -10.38960 1.000 18.45944 ? 149 ASP   A CA  1 
ATOM   1201 C  C   . ASP   A 1 149 ? -38.20063 15.73586 -11.46671 1.000 18.73656 ? 149 ASP   A C   1 
ATOM   1202 O  O   . ASP   A 1 149 ? -38.09804 15.27419 -12.60268 1.000 22.28408 ? 149 ASP   A O   1 
ATOM   1203 C  CB  . ASP   A 1 149 ? -40.33323 14.65237 -10.77556 1.000 19.51809 ? 149 ASP   A CB  1 
ATOM   1204 C  CG  . ASP   A 1 149 ? -41.01663 13.61272 -9.88916  1.000 24.19557 ? 149 ASP   A CG  1 
ATOM   1205 O  OD1 . ASP   A 1 149 ? -40.39405 12.57109 -9.57333  1.000 23.75069 ? 149 ASP   A OD1 1 
ATOM   1206 O  OD2 . ASP   A 1 149 ? -42.18051 13.85008 -9.50367  1.000 30.43135 ? 149 ASP   A OD2 1 
ATOM   1207 N  N   . ASP   A 1 150 ? -37.74416 16.94963 -11.14576 1.000 16.42485 ? 150 ASP   A N   1 
ATOM   1208 C  CA  . ASP   A 1 150 ? -37.14647 17.85269 -12.12749 1.000 19.00074 ? 150 ASP   A CA  1 
ATOM   1209 C  C   . ASP   A 1 150 ? -35.66888 18.12635 -11.91211 1.000 16.27365 ? 150 ASP   A C   1 
ATOM   1210 O  O   . ASP   A 1 150 ? -34.97014 18.41845 -12.88638 1.000 19.64975 ? 150 ASP   A O   1 
ATOM   1211 C  CB  . ASP   A 1 150 ? -37.86922 19.20336 -12.13746 1.000 19.04082 ? 150 ASP   A CB  1 
ATOM   1212 C  CG  . ASP   A 1 150 ? -39.37924 19.06674 -12.32413 1.000 22.72020 ? 150 ASP   A CG  1 
ATOM   1213 O  OD1 . ASP   A 1 150 ? -39.80415 18.39493 -13.29064 1.000 21.27685 ? 150 ASP   A OD1 1 
ATOM   1214 O  OD2 . ASP   A 1 150 ? -40.12595 19.63628 -11.49553 1.000 28.11433 ? 150 ASP   A OD2 1 
ATOM   1215 N  N   . ILE   A 1 151 ? -35.17167 18.04982 -10.67805 1.000 14.20810 ? 151 ILE   A N   1 
ATOM   1216 C  CA  . ILE   A 1 151 ? -33.81371 18.48632 -10.35030 1.000 15.62055 ? 151 ILE   A CA  1 
ATOM   1217 C  C   . ILE   A 1 151 ? -32.99065 17.26966 -9.96698  1.000 16.32464 ? 151 ILE   A C   1 
ATOM   1218 O  O   . ILE   A 1 151 ? -33.29914 16.58590 -8.98353  1.000 14.70814 ? 151 ILE   A O   1 
ATOM   1219 C  CB  . ILE   A 1 151 ? -33.80491 19.53902 -9.23395  1.000 16.57474 ? 151 ILE   A CB  1 
ATOM   1220 C  CG1 . ILE   A 1 151 ? -34.57317 20.77661 -9.68509  1.000 13.17526 ? 151 ILE   A CG1 1 
ATOM   1221 C  CG2 . ILE   A 1 151 ? -32.35519 19.90471 -8.85597  1.000 12.87878 ? 151 ILE   A CG2 1 
ATOM   1222 C  CD1 . ILE   A 1 151 ? -34.44598 21.94544 -8.71817  1.000 14.54757 ? 151 ILE   A CD1 1 
ATOM   1223 N  N   . LYS   A 1 152 ? -31.94907 16.99179 -10.75484 1.000 13.82948 ? 152 LYS   A N   1 
ATOM   1224 C  CA  . LYS   A 1 152 ? -31.19001 15.76509 -10.56067 1.000 12.81007 ? 152 LYS   A CA  1 
ATOM   1225 C  C   . LYS   A 1 152 ? -30.08446 15.93759 -9.52340  1.000 14.59489 ? 152 LYS   A C   1 
ATOM   1226 O  O   . LYS   A 1 152 ? -29.80627 15.00786 -8.75986  1.000 15.50170 ? 152 LYS   A O   1 
ATOM   1227 C  CB  . LYS   A 1 152 ? -30.61176 15.30697 -11.90309 1.000 20.26781 ? 152 LYS   A CB  1 
ATOM   1228 C  CG  . LYS   A 1 152 ? -29.74914 14.05718 -11.84027 1.000 22.68948 ? 152 LYS   A CG  1 
ATOM   1229 C  CD  . LYS   A 1 152 ? -29.54654 13.45980 -13.22981 1.000 34.50085 ? 152 LYS   A CD  1 
ATOM   1230 C  CE  . LYS   A 1 152 ? -28.64493 12.22338 -13.17813 1.000 41.38883 ? 152 LYS   A CE  1 
ATOM   1231 N  NZ  . LYS   A 1 152 ? -28.86791 11.27277 -14.31799 1.000 50.70733 ? 152 LYS   A NZ  1 
ATOM   1232 N  N   . TYR   A 1 153 ? -29.47512 17.12079 -9.45057  1.000 12.65012 ? 153 TYR   A N   1 
ATOM   1233 C  CA  . TYR   A 1 153 ? -28.28942 17.35437 -8.63011  1.000 11.62679 ? 153 TYR   A CA  1 
ATOM   1234 C  C   . TYR   A 1 153 ? -28.57354 18.39309 -7.55336  1.000 12.07896 ? 153 TYR   A C   1 
ATOM   1235 O  O   . TYR   A 1 153 ? -29.17458 19.43485 -7.82962  1.000 10.23891 ? 153 TYR   A O   1 
ATOM   1236 C  CB  . TYR   A 1 153 ? -27.10979 17.81812 -9.49681  1.000 12.98511 ? 153 TYR   A CB  1 
ATOM   1237 C  CG  . TYR   A 1 153 ? -26.78029 16.85251 -10.60940 1.000 14.71480 ? 153 TYR   A CG  1 
ATOM   1238 C  CD1 . TYR   A 1 153 ? -26.02225 15.72203 -10.35985 1.000 14.88979 ? 153 TYR   A CD1 1 
ATOM   1239 C  CD2 . TYR   A 1 153 ? -27.23438 17.06491 -11.90368 1.000 14.87148 ? 153 TYR   A CD2 1 
ATOM   1240 C  CE1 . TYR   A 1 153 ? -25.71365 14.81334 -11.37101 1.000 16.02777 ? 153 TYR   A CE1 1 
ATOM   1241 C  CE2 . TYR   A 1 153 ? -26.93134 16.16323 -12.93166 1.000 18.27457 ? 153 TYR   A CE2 1 
ATOM   1242 C  CZ  . TYR   A 1 153 ? -26.16805 15.03942 -12.65063 1.000 19.08226 ? 153 TYR   A CZ  1 
ATOM   1243 O  OH  . TYR   A 1 153 ? -25.87316 14.13521 -13.64171 1.000 19.78073 ? 153 TYR   A OH  1 
ATOM   1244 N  N   . TRP   A 1 154 ? -28.08621 18.13135 -6.33749  1.000 13.71782 ? 154 TRP   A N   1 
ATOM   1245 C  CA  . TRP   A 1 154 ? -28.43624 18.92113 -5.16218  1.000 12.41890 ? 154 TRP   A CA  1 
ATOM   1246 C  C   . TRP   A 1 154 ? -27.18687 19.28498 -4.37251  1.000 12.07847 ? 154 TRP   A C   1 
ATOM   1247 O  O   . TRP   A 1 154 ? -26.48335 18.39386 -3.88995  1.000 13.03557 ? 154 TRP   A O   1 
ATOM   1248 C  CB  . TRP   A 1 154 ? -29.41881 18.13898 -4.28111  1.000 13.88670 ? 154 TRP   A CB  1 
ATOM   1249 C  CG  . TRP   A 1 154 ? -30.75481 17.97672 -4.94595  1.000 12.00678 ? 154 TRP   A CG  1 
ATOM   1250 C  CD1 . TRP   A 1 154 ? -31.08467 17.09167 -5.94285  1.000 12.57636 ? 154 TRP   A CD1 1 
ATOM   1251 C  CD2 . TRP   A 1 154 ? -31.93786 18.73910 -4.67960  1.000 12.99592 ? 154 TRP   A CD2 1 
ATOM   1252 N  NE1 . TRP   A 1 154 ? -32.40738 17.25184 -6.30044  1.000 13.47799 ? 154 TRP   A NE1 1 
ATOM   1253 C  CE2 . TRP   A 1 154 ? -32.95134 18.26070 -5.54529  1.000 13.49258 ? 154 TRP   A CE2 1 
ATOM   1254 C  CE3 . TRP   A 1 154 ? -32.23910 19.78804 -3.80049  1.000 11.59765 ? 154 TRP   A CE3 1 
ATOM   1255 C  CZ2 . TRP   A 1 154 ? -34.23990 18.80101 -5.55773  1.000 13.16752 ? 154 TRP   A CZ2 1 
ATOM   1256 C  CZ3 . TRP   A 1 154 ? -33.51898 20.31966 -3.81466  1.000 12.60662 ? 154 TRP   A CZ3 1 
ATOM   1257 C  CH2 . TRP   A 1 154 ? -34.50387 19.82510 -4.68815  1.000 12.42234 ? 154 TRP   A CH2 1 
ATOM   1258 N  N   . ASP   A 1 155 ? -26.90679 20.59267 -4.24724  1.000 15.84833 ? 155 ASP   A N   1 
ATOM   1259 C  CA  . ASP   A 1 155 ? -26.01997 21.08947 -3.18980  1.000 13.25943 ? 155 ASP   A CA  1 
ATOM   1260 C  C   . ASP   A 1 155 ? -26.75594 21.01031 -1.84749  1.000 10.63398 ? 155 ASP   A C   1 
ATOM   1261 O  O   . ASP   A 1 155 ? -27.39479 21.98253 -1.43233  1.000 11.67950 ? 155 ASP   A O   1 
ATOM   1262 C  CB  . ASP   A 1 155 ? -25.58088 22.54734 -3.43566  1.000 10.32671 ? 155 ASP   A CB  1 
ATOM   1263 C  CG  . ASP   A 1 155 ? -24.56703 22.70281 -4.56836  1.000 14.20915 ? 155 ASP   A CG  1 
ATOM   1264 O  OD1 . ASP   A 1 155 ? -23.94493 21.69623 -4.97011  1.000 14.75479 ? 155 ASP   A OD1 1 
ATOM   1265 O  OD2 . ASP   A 1 155 ? -24.40425 23.85121 -5.06947  1.000 13.26625 ? 155 ASP   A OD2 1 
ATOM   1266 N  N   . VAL   A 1 156 ? -26.67537 19.87402 -1.15358  1.000 12.00562 ? 156 VAL   A N   1 
ATOM   1267 C  CA  . VAL   A 1 156 ? -27.38443 19.73160 0.11490   1.000 13.21896 ? 156 VAL   A CA  1 
ATOM   1268 C  C   . VAL   A 1 156 ? -26.83142 20.70000 1.15730   1.000 13.73158 ? 156 VAL   A C   1 
ATOM   1269 O  O   . VAL   A 1 156 ? -27.58928 21.36032 1.87697   1.000 12.89184 ? 156 VAL   A O   1 
ATOM   1270 C  CB  . VAL   A 1 156 ? -27.32492 18.27680 0.61112   1.000 16.04093 ? 156 VAL   A CB  1 
ATOM   1271 C  CG1 . VAL   A 1 156 ? -27.99956 18.16774 1.98460   1.000 16.27131 ? 156 VAL   A CG1 1 
ATOM   1272 C  CG2 . VAL   A 1 156 ? -28.01614 17.34287 -0.38591  1.000 14.17003 ? 156 VAL   A CG2 1 
ATOM   1273 N  N   . VAL   A 1 157 ? -25.50751 20.79143 1.27204   1.000 16.93100 ? 157 VAL   A N   1 
ATOM   1274 C  CA  . VAL   A 1 157 ? -24.88245 21.74691 2.18022   1.000 15.92350 ? 157 VAL   A CA  1 
ATOM   1275 C  C   . VAL   A 1 157 ? -23.80620 22.51060 1.42066   1.000 14.22591 ? 157 VAL   A C   1 
ATOM   1276 O  O   . VAL   A 1 157 ? -23.19680 21.99375 0.48030   1.000 15.76675 ? 157 VAL   A O   1 
ATOM   1277 C  CB  . VAL   A 1 157 ? -24.28239 21.07054 3.43409   1.000 16.27117 ? 157 VAL   A CB  1 
ATOM   1278 C  CG1 . VAL   A 1 157 ? -25.33774 20.29735 4.17491   1.000 13.37028 ? 157 VAL   A CG1 1 
ATOM   1279 C  CG2 . VAL   A 1 157 ? -23.09485 20.18483 3.06326   1.000 14.01816 ? 157 VAL   A CG2 1 
ATOM   1280 N  N   . ASN   A 1 158 ? -23.57651 23.75235 1.83816   1.000 15.33679 ? 158 ASN   A N   1 
ATOM   1281 C  CA  . ASN   A 1 158 ? -22.60288 24.63630 1.21738   1.000 15.20953 ? 158 ASN   A CA  1 
ATOM   1282 C  C   . ASN   A 1 158 ? -21.65086 25.16597 2.28719   1.000 17.29822 ? 158 ASN   A C   1 
ATOM   1283 O  O   . ASN   A 1 158 ? -22.09927 25.67335 3.31680   1.000 17.95431 ? 158 ASN   A O   1 
ATOM   1284 C  CB  . ASN   A 1 158 ? -23.31106 25.80646 0.50004   1.000 14.49792 ? 158 ASN   A CB  1 
ATOM   1285 C  CG  . ASN   A 1 158 ? -22.39607 26.53171 -0.51238  1.000 17.17004 ? 158 ASN   A CG  1 
ATOM   1286 O  OD1 . ASN   A 1 158 ? -21.49442 25.92927 -1.09791  1.000 16.75209 ? 158 ASN   A OD1 1 
ATOM   1287 N  ND2 . ASN   A 1 158 ? -22.63537 27.81731 -0.71298  1.000 13.17325 ? 158 ASN   A ND2 1 
ATOM   1288 N  N   . GLU   A 1 159 ? -20.34149 25.03114 2.04658   1.000 15.25559 ? 159 GLU   A N   1 
ATOM   1289 C  CA  . GLU   A 1 159 ? -19.29106 25.66633 2.84967   1.000 13.82637 ? 159 GLU   A CA  1 
ATOM   1290 C  C   . GLU   A 1 159 ? -19.38059 25.31530 4.33939   1.000 16.43725 ? 159 GLU   A C   1 
ATOM   1291 O  O   . GLU   A 1 159 ? -19.31959 26.18532 5.20780   1.000 16.18211 ? 159 GLU   A O   1 
ATOM   1292 C  CB  . GLU   A 1 159 ? -19.30858 27.17995 2.63931   1.000 12.22572 ? 159 GLU   A CB  1 
ATOM   1293 C  CG  . GLU   A 1 159 ? -19.07968 27.58098 1.17815   1.000 16.02715 ? 159 GLU   A CG  1 
ATOM   1294 C  CD  . GLU   A 1 159 ? -19.23440 29.08117 0.93676   1.000 18.53569 ? 159 GLU   A CD  1 
ATOM   1295 O  OE1 . GLU   A 1 159 ? -19.44994 29.82027 1.92348   1.000 14.10762 ? 159 GLU   A OE1 1 
ATOM   1296 O  OE2 . GLU   A 1 159 ? -19.14600 29.51367 -0.24278  1.000 17.80625 ? 159 GLU   A OE2 1 
ATOM   1297 N  N   . VAL   A 1 160 ? -19.47013 24.01641 4.64588   1.000 13.55432 ? 160 VAL   A N   1 
ATOM   1298 C  CA  . VAL   A 1 160 ? -19.59528 23.61306 6.04725   1.000 13.98422 ? 160 VAL   A CA  1 
ATOM   1299 C  C   . VAL   A 1 160 ? -18.25060 23.33505 6.70852   1.000 20.97075 ? 160 VAL   A C   1 
ATOM   1300 O  O   . VAL   A 1 160 ? -18.19661 23.19937 7.94081   1.000 20.15048 ? 160 VAL   A O   1 
ATOM   1301 C  CB  . VAL   A 1 160 ? -20.52631 22.39283 6.20620   1.000 13.09666 ? 160 VAL   A CB  1 
ATOM   1302 C  CG1 . VAL   A 1 160 ? -21.90222 22.70981 5.65185   1.000 14.15908 ? 160 VAL   A CG1 1 
ATOM   1303 C  CG2 . VAL   A 1 160 ? -19.95001 21.14083 5.55921   1.000 12.44586 ? 160 VAL   A CG2 1 
ATOM   1304 N  N   . VAL   A 1 161 ? -17.16115 23.27479 5.94379   1.000 17.60537 ? 161 VAL   A N   1 
ATOM   1305 C  CA  . VAL   A 1 161 ? -15.82512 23.09403 6.49751   1.000 19.64329 ? 161 VAL   A CA  1 
ATOM   1306 C  C   . VAL   A 1 161 ? -15.12299 24.44257 6.47980   1.000 19.95427 ? 161 VAL   A C   1 
ATOM   1307 O  O   . VAL   A 1 161 ? -15.13841 25.14475 5.46008   1.000 21.59016 ? 161 VAL   A O   1 
ATOM   1308 C  CB  . VAL   A 1 161 ? -15.02875 22.03973 5.70986   1.000 19.57055 ? 161 VAL   A CB  1 
ATOM   1309 C  CG1 . VAL   A 1 161 ? -13.61578 21.94343 6.23222   1.000 17.58867 ? 161 VAL   A CG1 1 
ATOM   1310 C  CG2 . VAL   A 1 161 ? -15.71517 20.69318 5.78386   1.000 19.99084 ? 161 VAL   A CG2 1 
ATOM   1311 N  N   . GLY   A 1 162 ? -14.53197 24.81721 7.61069   1.000 16.62580 ? 162 GLY   A N   1 
ATOM   1312 C  CA  . GLY   A 1 162 ? -13.81359 26.06465 7.68870   1.000 20.12915 ? 162 GLY   A CA  1 
ATOM   1313 C  C   . GLY   A 1 162 ? -12.45910 26.00539 7.00720   1.000 22.02468 ? 162 GLY   A C   1 
ATOM   1314 O  O   . GLY   A 1 162 ? -11.87897 24.94586 6.79101   1.000 22.38935 ? 162 GLY   A O   1 
ATOM   1315 N  N   . ASP   A 1 163 ? -11.95500 27.18714 6.65664   1.000 22.15347 ? 163 ASP   A N   1 
ATOM   1316 C  CA  . ASP   A 1 163 ? -10.63379 27.29447 6.05660   1.000 20.73843 ? 163 ASP   A CA  1 
ATOM   1317 C  C   . ASP   A 1 163 ? -9.51178  26.88462 7.01686   1.000 28.46435 ? 163 ASP   A C   1 
ATOM   1318 O  O   . ASP   A 1 163 ? -8.42167  26.51681 6.55567   1.000 23.03312 ? 163 ASP   A O   1 
ATOM   1319 C  CB  . ASP   A 1 163 ? -10.43449 28.72287 5.54770   1.000 19.61089 ? 163 ASP   A CB  1 
ATOM   1320 C  CG  . ASP   A 1 163 ? -11.32183 29.03835 4.34256   1.000 19.80689 ? 163 ASP   A CG  1 
ATOM   1321 O  OD1 . ASP   A 1 163 ? -11.46223 28.16318 3.46494   1.000 21.58189 ? 163 ASP   A OD1 1 
ATOM   1322 O  OD2 . ASP   A 1 163 ? -11.88648 30.14831 4.26996   1.000 20.42953 ? 163 ASP   A OD2 1 
ATOM   1323 N  N   . ASP   A 1 164 ? -9.75736  26.91023 8.32976   1.000 23.06435 ? 164 ASP   A N   1 
ATOM   1324 C  CA  . ASP   A 1 164 ? -8.79495  26.42571 9.31656   1.000 24.32501 ? 164 ASP   A CA  1 
ATOM   1325 C  C   . ASP   A 1 164 ? -8.82574  24.91206 9.48515   1.000 28.22394 ? 164 ASP   A C   1 
ATOM   1326 O  O   . ASP   A 1 164 ? -8.15167  24.38885 10.37541  1.000 25.54971 ? 164 ASP   A O   1 
ATOM   1327 C  CB  . ASP   A 1 164 ? -9.03698  27.09726 10.67847  1.000 26.02284 ? 164 ASP   A CB  1 
ATOM   1328 C  CG  . ASP   A 1 164 ? -10.42264 26.78071 11.27222  1.000 27.09519 ? 164 ASP   A CG  1 
ATOM   1329 O  OD1 . ASP   A 1 164 ? -11.21325 26.02469 10.66077  1.000 26.19816 ? 164 ASP   A OD1 1 
ATOM   1330 O  OD2 . ASP   A 1 164 ? -10.71868 27.29392 12.36948  1.000 24.96711 ? 164 ASP   A OD2 1 
ATOM   1331 N  N   . GLY   A 1 165 ? -9.59336  24.19610 8.67285   1.000 24.84056 ? 165 GLY   A N   1 
ATOM   1332 C  CA  . GLY   A 1 165 ? -9.62816  22.75592 8.76927   1.000 22.33551 ? 165 GLY   A CA  1 
ATOM   1333 C  C   . GLY   A 1 165 ? -10.51745 22.22104 9.86574   1.000 22.99236 ? 165 GLY   A C   1 
ATOM   1334 O  O   . GLY   A 1 165 ? -10.59262 20.99943 10.03738  1.000 28.15639 ? 165 GLY   A O   1 
ATOM   1335 N  N   . LYS   A 1 166 ? -11.16369 23.08833 10.63099  1.000 21.33345 ? 166 LYS   A N   1 
ATOM   1336 C  CA  . LYS   A 1 166 ? -12.22584 22.69050 11.54184  1.000 27.15687 ? 166 LYS   A CA  1 
ATOM   1337 C  C   . LYS   A 1 166 ? -13.56820 22.87341 10.84327  1.000 26.28045 ? 166 LYS   A C   1 
ATOM   1338 O  O   . LYS   A 1 166 ? -13.67183 23.58030 9.83732   1.000 20.64614 ? 166 LYS   A O   1 
ATOM   1339 C  CB  . LYS   A 1 166 ? -12.18758 23.51818 12.83273  1.000 23.84485 ? 166 LYS   A CB  1 
ATOM   1340 C  CG  . LYS   A 1 166 ? -10.84334 23.50340 13.56722  1.000 30.35070 ? 166 LYS   A CG  1 
ATOM   1341 C  CD  . LYS   A 1 166 ? -10.27453 22.09412 13.66136  1.000 41.73066 ? 166 LYS   A CD  1 
ATOM   1342 C  CE  . LYS   A 1 166 ? -9.28042  21.93686 14.82056  1.000 54.85652 ? 166 LYS   A CE  1 
ATOM   1343 N  NZ  . LYS   A 1 166 ? -8.78433  20.52387 14.93097  1.000 49.78707 ? 166 LYS   A NZ  1 
ATOM   1344 N  N   . LEU   A 1 167 ? -14.60103 22.22646 11.37775  1.000 22.41484 ? 167 LEU   A N   1 
ATOM   1345 C  CA  . LEU   A 1 167 ? -15.93480 22.49537 10.86465  1.000 20.42677 ? 167 LEU   A CA  1 
ATOM   1346 C  C   . LEU   A 1 167 ? -16.23660 23.97264 11.07255  1.000 24.13152 ? 167 LEU   A C   1 
ATOM   1347 O  O   . LEU   A 1 167 ? -15.81097 24.56651 12.06531  1.000 25.80497 ? 167 LEU   A O   1 
ATOM   1348 C  CB  . LEU   A 1 167 ? -16.96709 21.61129 11.55785  1.000 19.20901 ? 167 LEU   A CB  1 
ATOM   1349 C  CG  . LEU   A 1 167 ? -16.99121 20.16664 11.04238  1.000 23.89580 ? 167 LEU   A CG  1 
ATOM   1350 C  CD1 . LEU   A 1 167 ? -17.47761 19.19963 12.10057  1.000 29.09389 ? 167 LEU   A CD1 1 
ATOM   1351 C  CD2 . LEU   A 1 167 ? -17.88068 20.05757 9.81609   1.000 30.70810 ? 167 LEU   A CD2 1 
ATOM   1352 N  N   . ARG   A 1 168 ? -16.89565 24.59080 10.09316  1.000 21.30458 ? 168 ARG   A N   1 
ATOM   1353 C  CA  . ARG   A 1 168 ? -17.23579 26.00125 10.22063  1.000 20.65447 ? 168 ARG   A CA  1 
ATOM   1354 C  C   . ARG   A 1 168 ? -18.14778 26.19506 11.42814  1.000 25.04107 ? 168 ARG   A C   1 
ATOM   1355 O  O   . ARG   A 1 168 ? -19.13993 25.47664 11.59147  1.000 23.55673 ? 168 ARG   A O   1 
ATOM   1356 C  CB  . ARG   A 1 168 ? -17.91763 26.50721 8.94792   1.000 16.70252 ? 168 ARG   A CB  1 
ATOM   1357 C  CG  . ARG   A 1 168 ? -18.23620 27.99521 8.97834   1.000 18.00093 ? 168 ARG   A CG  1 
ATOM   1358 C  CD  . ARG   A 1 168 ? -18.93469 28.45706 7.70145   1.000 21.70581 ? 168 ARG   A CD  1 
ATOM   1359 N  NE  . ARG   A 1 168 ? -18.04495 28.39731 6.54651   1.000 17.26665 ? 168 ARG   A NE  1 
ATOM   1360 C  CZ  . ARG   A 1 168 ? -17.17340 29.35402 6.22698   1.000 24.15333 ? 168 ARG   A CZ  1 
ATOM   1361 N  NH1 . ARG   A 1 168 ? -17.09761 30.45411 6.97826   1.000 19.01291 ? 168 ARG   A NH1 1 
ATOM   1362 N  NH2 . ARG   A 1 168 ? -16.38218 29.21937 5.15498   1.000 15.91065 ? 168 ARG   A NH2 1 
ATOM   1363 N  N   . ASN   A 1 169 ? -17.79493 27.14683 12.28690  1.000 22.48712 ? 169 ASN   A N   1 
ATOM   1364 C  CA  . ASN   A 1 169 ? -18.54917 27.38873 13.51431  1.000 23.89503 ? 169 ASN   A CA  1 
ATOM   1365 C  C   . ASN   A 1 169 ? -19.71531 28.33868 13.26611  1.000 23.53375 ? 169 ASN   A C   1 
ATOM   1366 O  O   . ASN   A 1 169 ? -19.87038 29.37102 13.91438  1.000 23.08221 ? 169 ASN   A O   1 
ATOM   1367 C  CB  . ASN   A 1 169 ? -17.62626 27.91599 14.60967  1.000 19.34882 ? 169 ASN   A CB  1 
ATOM   1368 C  CG  . ASN   A 1 169 ? -18.19524 27.68952 16.01098  1.000 28.60324 ? 169 ASN   A CG  1 
ATOM   1369 O  OD1 . ASN   A 1 169 ? -18.86801 26.68634 16.27380  1.000 31.77291 ? 169 ASN   A OD1 1 
ATOM   1370 N  ND2 . ASN   A 1 169 ? -17.93773 28.62746 16.91015  1.000 28.64265 ? 169 ASN   A ND2 1 
ATOM   1371 N  N   . SER   A 1 170 ? -20.55597 27.97683 12.30307  1.000 26.12392 ? 170 SER   A N   1 
ATOM   1372 C  CA  . SER   A 1 170 ? -21.76043 28.73350 12.00591  1.000 26.01588 ? 170 SER   A CA  1 
ATOM   1373 C  C   . SER   A 1 170 ? -22.81310 28.48079 13.08700  1.000 21.92329 ? 170 SER   A C   1 
ATOM   1374 O  O   . SER   A 1 170 ? -22.69138 27.54549 13.88081  1.000 21.09301 ? 170 SER   A O   1 
ATOM   1375 C  CB  . SER   A 1 170 ? -22.29941 28.32559 10.63528  1.000 20.82039 ? 170 SER   A CB  1 
ATOM   1376 O  OG  . SER   A 1 170 ? -22.81716 27.00713 10.69070  1.000 25.49776 ? 170 SER   A OG  1 
ATOM   1377 N  N   . PRO   A 1 171 ? -23.87661 29.28595 13.12746  1.000 23.35466 ? 171 PRO   A N   1 
ATOM   1378 C  CA  . PRO   A 1 171 ? -24.98552 28.95724 14.03941  1.000 22.73508 ? 171 PRO   A CA  1 
ATOM   1379 C  C   . PRO   A 1 171 ? -25.50194 27.53629 13.86165  1.000 23.19413 ? 171 PRO   A C   1 
ATOM   1380 O  O   . PRO   A 1 171 ? -25.82314 26.87961 14.86221  1.000 23.32137 ? 171 PRO   A O   1 
ATOM   1381 C  CB  . PRO   A 1 171 ? -26.03895 30.01325 13.68989  1.000 23.77800 ? 171 PRO   A CB  1 
ATOM   1382 C  CG  . PRO   A 1 171 ? -25.24141 31.18203 13.19103  1.000 20.47627 ? 171 PRO   A CG  1 
ATOM   1383 C  CD  . PRO   A 1 171 ? -24.04836 30.60743 12.49245  1.000 21.54917 ? 171 PRO   A CD  1 
ATOM   1384 N  N   . TRP   A 1 172 ? -25.56719 27.03288 12.61870  1.000 23.32055 ? 172 TRP   A N   1 
ATOM   1385 C  CA  . TRP   A 1 172 ? -25.91266 25.62959 12.39363  1.000 19.21972 ? 172 TRP   A CA  1 
ATOM   1386 C  C   . TRP   A 1 172 ? -25.08876 24.72404 13.29556  1.000 22.08895 ? 172 TRP   A C   1 
ATOM   1387 O  O   . TRP   A 1 172 ? -25.62147 23.82914 13.96337  1.000 21.92253 ? 172 TRP   A O   1 
ATOM   1388 C  CB  . TRP   A 1 172 ? -25.68278 25.24532 10.92830  1.000 17.51721 ? 172 TRP   A CB  1 
ATOM   1389 C  CG  . TRP   A 1 172 ? -26.61106 25.88285 9.96780   1.000 19.14566 ? 172 TRP   A CG  1 
ATOM   1390 C  CD1 . TRP   A 1 172 ? -26.30518 26.82812 9.02992   1.000 19.40739 ? 172 TRP   A CD1 1 
ATOM   1391 C  CD2 . TRP   A 1 172 ? -28.00826 25.62055 9.83315   1.000 16.67290 ? 172 TRP   A CD2 1 
ATOM   1392 N  NE1 . TRP   A 1 172 ? -27.43464 27.17043 8.31969   1.000 17.62181 ? 172 TRP   A NE1 1 
ATOM   1393 C  CE2 . TRP   A 1 172 ? -28.49311 26.44901 8.79726   1.000 17.99743 ? 172 TRP   A CE2 1 
ATOM   1394 C  CE3 . TRP   A 1 172 ? -28.90442 24.77987 10.50207  1.000 19.92879 ? 172 TRP   A CE3 1 
ATOM   1395 C  CZ2 . TRP   A 1 172 ? -29.83865 26.45675 8.40734   1.000 18.36617 ? 172 TRP   A CZ2 1 
ATOM   1396 C  CZ3 . TRP   A 1 172 ? -30.24237 24.78381 10.10968  1.000 18.51575 ? 172 TRP   A CZ3 1 
ATOM   1397 C  CH2 . TRP   A 1 172 ? -30.69177 25.61923 9.07091   1.000 20.94824 ? 172 TRP   A CH2 1 
ATOM   1398 N  N   . TYR   A 1 173 ? -23.77719 24.96251 13.33482  1.000 19.73486 ? 173 TYR   A N   1 
ATOM   1399 C  CA  . TYR   A 1 173 ? -22.87821 24.09591 14.07941  1.000 23.75953 ? 173 TYR   A CA  1 
ATOM   1400 C  C   . TYR   A 1 173 ? -22.89821 24.40485 15.57484  1.000 22.62240 ? 173 TYR   A C   1 
ATOM   1401 O  O   . TYR   A 1 173 ? -22.86199 23.48514 16.39160  1.000 23.63887 ? 173 TYR   A O   1 
ATOM   1402 C  CB  . TYR   A 1 173 ? -21.46093 24.21907 13.52488  1.000 20.53407 ? 173 TYR   A CB  1 
ATOM   1403 C  CG  . TYR   A 1 173 ? -20.50871 23.22767 14.13637  1.000 22.07385 ? 173 TYR   A CG  1 
ATOM   1404 C  CD1 . TYR   A 1 173 ? -20.59309 21.87910 13.82798  1.000 19.67880 ? 173 TYR   A CD1 1 
ATOM   1405 C  CD2 . TYR   A 1 173 ? -19.53908 23.63722 15.04090  1.000 25.50010 ? 173 TYR   A CD2 1 
ATOM   1406 C  CE1 . TYR   A 1 173 ? -19.72942 20.96131 14.39420  1.000 23.89261 ? 173 TYR   A CE1 1 
ATOM   1407 C  CE2 . TYR   A 1 173 ? -18.66547 22.72475 15.61615  1.000 28.20500 ? 173 TYR   A CE2 1 
ATOM   1408 C  CZ  . TYR   A 1 173 ? -18.76819 21.39118 15.28668  1.000 25.98343 ? 173 TYR   A CZ  1 
ATOM   1409 O  OH  . TYR   A 1 173 ? -17.90775 20.48391 15.84721  1.000 29.83315 ? 173 TYR   A OH  1 
ATOM   1410 N  N   . GLN   A 1 174 ? -22.95363 25.68336 15.95625  1.000 21.68397 ? 174 GLN   A N   1 
ATOM   1411 C  CA  . GLN   A 1 174 ? -22.98073 26.01660 17.37743  1.000 24.43051 ? 174 GLN   A CA  1 
ATOM   1412 C  C   . GLN   A 1 174 ? -24.23430 25.47603 18.04114  1.000 25.44322 ? 174 GLN   A C   1 
ATOM   1413 O  O   . GLN   A 1 174 ? -24.19483 25.02301 19.18891  1.000 30.00650 ? 174 GLN   A O   1 
ATOM   1414 C  CB  . GLN   A 1 174 ? -22.92643 27.52320 17.58417  1.000 23.36085 ? 174 GLN   A CB  1 
ATOM   1415 C  CG  . GLN   A 1 174 ? -21.73019 28.20485 17.06784  1.000 24.29269 ? 174 GLN   A CG  1 
ATOM   1416 C  CD  . GLN   A 1 174 ? -21.87601 29.69703 17.21985  1.000 30.79581 ? 174 GLN   A CD  1 
ATOM   1417 O  OE1 . GLN   A 1 174 ? -22.27983 30.18005 18.27466  1.000 35.33510 ? 174 GLN   A OE1 1 
ATOM   1418 N  NE2 . GLN   A 1 174 ? -21.57847 30.43886 16.15780  1.000 29.01165 ? 174 GLN   A NE2 1 
ATOM   1419 N  N   . ILE   A 1 175 ? -25.35957 25.52531 17.33309  1.000 26.29206 ? 175 ILE   A N   1 
ATOM   1420 C  CA  . ILE   A 1 175 ? -26.62968 25.12814 17.91950  1.000 25.17510 ? 175 ILE   A CA  1 
ATOM   1421 C  C   . ILE   A 1 175 ? -26.81353 23.62144 17.87040  1.000 24.42036 ? 175 ILE   A C   1 
ATOM   1422 O  O   . ILE   A 1 175 ? -27.25881 23.01512 18.84851  1.000 31.24033 ? 175 ILE   A O   1 
ATOM   1423 C  CB  . ILE   A 1 175 ? -27.77622 25.85753 17.21035  1.000 24.52516 ? 175 ILE   A CB  1 
ATOM   1424 C  CG1 . ILE   A 1 175 ? -27.70236 27.35487 17.52275  1.000 22.64606 ? 175 ILE   A CG1 1 
ATOM   1425 C  CG2 . ILE   A 1 175 ? -29.09939 25.24577 17.60462  1.000 23.88436 ? 175 ILE   A CG2 1 
ATOM   1426 C  CD1 . ILE   A 1 175 ? -28.51407 28.22399 16.58748  1.000 23.98530 ? 175 ILE   A CD1 1 
ATOM   1427 N  N   . ALA   A 1 176 ? -26.46448 22.98304 16.74955  1.000 25.50189 ? 176 ALA   A N   1 
ATOM   1428 C  CA  . ALA   A 1 176 ? -26.83052 21.59294 16.52537  1.000 24.48833 ? 176 ALA   A CA  1 
ATOM   1429 C  C   . ALA   A 1 176 ? -25.66292 20.63487 16.35777  1.000 24.80951 ? 176 ALA   A C   1 
ATOM   1430 O  O   . ALA   A 1 176 ? -25.89974 19.42238 16.29306  1.000 24.27544 ? 176 ALA   A O   1 
ATOM   1431 C  CB  . ALA   A 1 176 ? -27.73309 21.47422 15.28766  1.000 23.66769 ? 176 ALA   A CB  1 
ATOM   1432 N  N   . GLY   A 1 177 ? -24.42509 21.12544 16.28297  1.000 23.77730 ? 177 GLY   A N   1 
ATOM   1433 C  CA  . GLY   A 1 177 ? -23.30176 20.23172 16.06914  1.000 24.55874 ? 177 GLY   A CA  1 
ATOM   1434 C  C   . GLY   A 1 177 ? -23.32112 19.63398 14.66678  1.000 26.71908 ? 177 GLY   A C   1 
ATOM   1435 O  O   . GLY   A 1 177 ? -24.01669 20.10494 13.76131  1.000 24.17905 ? 177 GLY   A O   1 
ATOM   1436 N  N   . ILE   A 1 178 ? -22.55388 18.55129 14.50701  1.000 23.02148 ? 178 ILE   A N   1 
ATOM   1437 C  CA  . ILE   A 1 178 ? -22.40055 17.90251 13.20783  1.000 23.89037 ? 178 ILE   A CA  1 
ATOM   1438 C  C   . ILE   A 1 178 ? -23.71342 17.31598 12.69462  1.000 26.02261 ? 178 ILE   A C   1 
ATOM   1439 O  O   . ILE   A 1 178 ? -23.84021 17.03804 11.49283  1.000 23.65099 ? 178 ILE   A O   1 
ATOM   1440 C  CB  . ILE   A 1 178 ? -21.29726 16.81638 13.29146  1.000 26.42842 ? 178 ILE   A CB  1 
ATOM   1441 C  CG1 . ILE   A 1 178 ? -20.81639 16.40512 11.90020  1.000 20.80755 ? 178 ILE   A CG1 1 
ATOM   1442 C  CG2 . ILE   A 1 178 ? -21.78698 15.58592 14.04339  1.000 26.72736 ? 178 ILE   A CG2 1 
ATOM   1443 C  CD1 . ILE   A 1 178 ? -19.80079 15.27453 11.90679  1.000 26.96929 ? 178 ILE   A CD1 1 
ATOM   1444 N  N   . ASP   A 1 179 ? -24.71127 17.14323 13.56879  1.000 23.75495 ? 179 ASP   A N   1 
ATOM   1445 C  CA  . ASP   A 1 179 ? -25.94026 16.47114 13.15983  1.000 21.94562 ? 179 ASP   A CA  1 
ATOM   1446 C  C   . ASP   A 1 179 ? -26.71720 17.25877 12.10385  1.000 21.08402 ? 179 ASP   A C   1 
ATOM   1447 O  O   . ASP   A 1 179 ? -27.49606 16.65624 11.35192  1.000 20.78622 ? 179 ASP   A O   1 
ATOM   1448 C  CB  . ASP   A 1 179 ? -26.83649 16.20116 14.38291  1.000 27.25848 ? 179 ASP   A CB  1 
ATOM   1449 C  CG  . ASP   A 1 179 ? -26.46681 14.90330 15.12731  1.000 32.50764 ? 179 ASP   A CG  1 
ATOM   1450 O  OD1 . ASP   A 1 179 ? -25.73961 14.05847 14.56350  1.000 34.24745 ? 179 ASP   A OD1 1 
ATOM   1451 O  OD2 . ASP   A 1 179 ? -26.91281 14.72330 16.28447  1.000 33.18680 ? 179 ASP   A OD2 1 
ATOM   1452 N  N   . TYR   A 1 180 ? -26.54103 18.58376 12.02943  1.000 18.42721 ? 180 TYR   A N   1 
ATOM   1453 C  CA  . TYR   A 1 180 ? -27.26308 19.33465 11.00698  1.000 19.99465 ? 180 TYR   A CA  1 
ATOM   1454 C  C   . TYR   A 1 180 ? -26.85017 18.88625 9.61380   1.000 19.36501 ? 180 TYR   A C   1 
ATOM   1455 O  O   . TYR   A 1 180 ? -27.69471 18.81947 8.71046   1.000 19.45755 ? 180 TYR   A O   1 
ATOM   1456 C  CB  . TYR   A 1 180 ? -27.08030 20.84875 11.20163  1.000 17.85508 ? 180 TYR   A CB  1 
ATOM   1457 C  CG  . TYR   A 1 180 ? -25.86718 21.50423 10.55390  1.000 19.41487 ? 180 TYR   A CG  1 
ATOM   1458 C  CD1 . TYR   A 1 180 ? -24.66611 21.62398 11.24502  1.000 19.03500 ? 180 TYR   A CD1 1 
ATOM   1459 C  CD2 . TYR   A 1 180 ? -25.93996 22.05318 9.27278   1.000 18.02897 ? 180 TYR   A CD2 1 
ATOM   1460 C  CE1 . TYR   A 1 180 ? -23.55693 22.23517 10.67358  1.000 18.88613 ? 180 TYR   A CE1 1 
ATOM   1461 C  CE2 . TYR   A 1 180 ? -24.83485 22.66650 8.69239   1.000 18.40880 ? 180 TYR   A CE2 1 
ATOM   1462 C  CZ  . TYR   A 1 180 ? -23.64369 22.75306 9.40182   1.000 18.73927 ? 180 TYR   A CZ  1 
ATOM   1463 O  OH  . TYR   A 1 180 ? -22.54415 23.36734 8.85173   1.000 17.10251 ? 180 TYR   A OH  1 
ATOM   1464 N  N   . ILE   A 1 181 ? -25.58508 18.49936 9.44045   1.000 18.94180 ? 181 ILE   A N   1 
ATOM   1465 C  CA  . ILE   A 1 181 ? -25.12959 17.98193 8.14937   1.000 19.75064 ? 181 ILE   A CA  1 
ATOM   1466 C  C   . ILE   A 1 181 ? -25.75710 16.61873 7.86195   1.000 21.00407 ? 181 ILE   A C   1 
ATOM   1467 O  O   . ILE   A 1 181 ? -26.25257 16.36245 6.75443   1.000 19.74622 ? 181 ILE   A O   1 
ATOM   1468 C  CB  . ILE   A 1 181 ? -23.59344 17.91843 8.12028   1.000 19.53583 ? 181 ILE   A CB  1 
ATOM   1469 C  CG1 . ILE   A 1 181 ? -23.00132 19.33241 8.24932   1.000 17.27310 ? 181 ILE   A CG1 1 
ATOM   1470 C  CG2 . ILE   A 1 181 ? -23.10274 17.21081 6.86066   1.000 18.80898 ? 181 ILE   A CG2 1 
ATOM   1471 C  CD1 . ILE   A 1 181 ? -21.50851 19.34519 8.51980   1.000 19.27056 ? 181 ILE   A CD1 1 
ATOM   1472 N  N   . LYS   A 1 182 ? -25.74403 15.72166 8.85173   1.000 22.07736 ? 182 LYS   A N   1 
ATOM   1473 C  CA  . LYS   A 1 182 ? -26.37109 14.41215 8.67148   1.000 22.85659 ? 182 LYS   A CA  1 
ATOM   1474 C  C   . LYS   A 1 182 ? -27.86780 14.54189 8.39267   1.000 21.51721 ? 182 LYS   A C   1 
ATOM   1475 O  O   . LYS   A 1 182 ? -28.40298 13.85155 7.51367   1.000 22.37819 ? 182 LYS   A O   1 
ATOM   1476 C  CB  . LYS   A 1 182 ? -26.14249 13.53738 9.90819   1.000 26.21580 ? 182 LYS   A CB  1 
ATOM   1477 C  CG  . LYS   A 1 182 ? -24.71567 13.53213 10.43104  1.000 27.50435 ? 182 LYS   A CG  1 
ATOM   1478 C  CD  . LYS   A 1 182 ? -24.54071 12.52301 11.56775  1.000 29.42024 ? 182 LYS   A CD  1 
ATOM   1479 C  CE  . LYS   A 1 182 ? -23.13723 12.61883 12.17503  1.000 38.56380 ? 182 LYS   A CE  1 
ATOM   1480 N  NZ  . LYS   A 1 182 ? -22.77985 11.47758 13.08094  1.000 40.26728 ? 182 LYS   A NZ  1 
ATOM   1481 N  N   . VAL   A 1 183 ? -28.55760 15.42131 9.13029   1.000 18.76622 ? 183 VAL   A N   1 
ATOM   1482 C  CA  . VAL   A 1 183 ? -30.00488 15.56884 8.96915   1.000 20.23512 ? 183 VAL   A CA  1 
ATOM   1483 C  C   . VAL   A 1 183 ? -30.32531 16.08712 7.57661   1.000 19.83760 ? 183 VAL   A C   1 
ATOM   1484 O  O   . VAL   A 1 183 ? -31.29402 15.64974 6.94159   1.000 20.67676 ? 183 VAL   A O   1 
ATOM   1485 C  CB  . VAL   A 1 183 ? -30.58163 16.48831 10.06597  1.000 19.74577 ? 183 VAL   A CB  1 
ATOM   1486 C  CG1 . VAL   A 1 183 ? -31.94694 17.06026 9.66181   1.000 16.50349 ? 183 VAL   A CG1 1 
ATOM   1487 C  CG2 . VAL   A 1 183 ? -30.70282 15.73894 11.37160  1.000 22.58339 ? 183 VAL   A CG2 1 
ATOM   1488 N  N   . ALA   A 1 184 ? -29.49502 16.99522 7.06361   1.000 16.34065 ? 184 ALA   A N   1 
ATOM   1489 C  CA  . ALA   A 1 184 ? -29.77155 17.58779 5.76139   1.000 15.17089 ? 184 ALA   A CA  1 
ATOM   1490 C  C   . ALA   A 1 184 ? -29.71331 16.53429 4.66178   1.000 18.26412 ? 184 ALA   A C   1 
ATOM   1491 O  O   . ALA   A 1 184 ? -30.60704 16.45611 3.80943   1.000 14.72505 ? 184 ALA   A O   1 
ATOM   1492 C  CB  . ALA   A 1 184 ? -28.80004 18.73604 5.48371   1.000 11.99620 ? 184 ALA   A CB  1 
ATOM   1493 N  N   . PHE   A 1 185 ? -28.68778 15.68556 4.68644   1.000 16.81118 ? 185 PHE   A N   1 
ATOM   1494 C  CA  . PHE   A 1 185 ? -28.57836 14.65875 3.65697   1.000 16.03092 ? 185 PHE   A CA  1 
ATOM   1495 C  C   . PHE   A 1 185 ? -29.65536 13.58476 3.81950   1.000 20.64207 ? 185 PHE   A C   1 
ATOM   1496 O  O   . PHE   A 1 185 ? -30.26049 13.15391 2.82801   1.000 21.75718 ? 185 PHE   A O   1 
ATOM   1497 C  CB  . PHE   A 1 185 ? -27.17619 14.03960 3.67954   1.000 19.55715 ? 185 PHE   A CB  1 
ATOM   1498 C  CG  . PHE   A 1 185 ? -26.11618 14.88639 2.99858   1.000 17.70669 ? 185 PHE   A CG  1 
ATOM   1499 C  CD1 . PHE   A 1 185 ? -25.93836 14.82737 1.62510   1.000 20.72273 ? 185 PHE   A CD1 1 
ATOM   1500 C  CD2 . PHE   A 1 185 ? -25.30782 15.73775 3.73480   1.000 16.15528 ? 185 PHE   A CD2 1 
ATOM   1501 C  CE1 . PHE   A 1 185 ? -24.95844 15.60012 0.99455   1.000 18.00079 ? 185 PHE   A CE1 1 
ATOM   1502 C  CE2 . PHE   A 1 185 ? -24.33515 16.51644 3.11741   1.000 18.09622 ? 185 PHE   A CE2 1 
ATOM   1503 C  CZ  . PHE   A 1 185 ? -24.15490 16.44403 1.74966   1.000 17.95003 ? 185 PHE   A CZ  1 
ATOM   1504 N  N   . GLN   A 1 186 ? -29.90811 13.13546 5.05615   1.000 17.82488 ? 186 GLN   A N   1 
ATOM   1505 C  CA  . GLN   A 1 186 ? -30.93622 12.12207 5.27742   1.000 23.16566 ? 186 GLN   A CA  1 
ATOM   1506 C  C   . GLN   A 1 186 ? -32.29601 12.61712 4.79989   1.000 21.15832 ? 186 GLN   A C   1 
ATOM   1507 O  O   . GLN   A 1 186 ? -33.03583 11.89350 4.12001   1.000 20.69062 ? 186 GLN   A O   1 
ATOM   1508 C  CB  . GLN   A 1 186 ? -30.99645 11.73769 6.76364   1.000 23.72975 ? 186 GLN   A CB  1 
ATOM   1509 C  CG  . GLN   A 1 186 ? -29.74098 11.04425 7.31251   1.000 25.21316 ? 186 GLN   A CG  1 
ATOM   1510 C  CD  . GLN   A 1 186 ? -29.56810 9.59920  6.82995   1.000 35.01031 ? 186 GLN   A CD  1 
ATOM   1511 O  OE1 . GLN   A 1 186 ? -30.29898 9.11698  5.94897   1.000 31.22307 ? 186 GLN   A OE1 1 
ATOM   1512 N  NE2 . GLN   A 1 186 ? -28.58362 8.89876  7.41008   1.000 38.94430 ? 186 GLN   A NE2 1 
ATOM   1513 N  N   . ALA   A 1 187 ? -32.63842 13.85980 5.14674   1.000 21.56535 ? 187 ALA   A N   1 
ATOM   1514 C  CA  . ALA   A 1 187 ? -33.91525 14.41961 4.72195   1.000 20.02899 ? 187 ALA   A CA  1 
ATOM   1515 C  C   . ALA   A 1 187 ? -34.00036 14.51310 3.20184   1.000 18.50676 ? 187 ALA   A C   1 
ATOM   1516 O  O   . ALA   A 1 187 ? -35.04767 14.22760 2.60856   1.000 21.70102 ? 187 ALA   A O   1 
ATOM   1517 C  CB  . ALA   A 1 187 ? -34.11841 15.79353 5.36992   1.000 14.65945 ? 187 ALA   A CB  1 
ATOM   1518 N  N   . ALA   A 1 188 ? -32.91667 14.92393 2.54908   1.000 16.93773 ? 188 ALA   A N   1 
ATOM   1519 C  CA  . ALA   A 1 188 ? -32.95130 15.02232 1.09322   1.000 23.17137 ? 188 ALA   A CA  1 
ATOM   1520 C  C   . ALA   A 1 188 ? -33.17852 13.65389 0.46703   1.000 19.59588 ? 188 ALA   A C   1 
ATOM   1521 O  O   . ALA   A 1 188 ? -34.00337 13.50216 -0.44409  1.000 19.07450 ? 188 ALA   A O   1 
ATOM   1522 C  CB  . ALA   A 1 188 ? -31.66068 15.66181 0.57035   1.000 14.65793 ? 188 ALA   A CB  1 
ATOM   1523 N  N   . ARG   A 1 189 ? -32.46347 12.63513 0.95431   1.000 18.70222 ? 189 ARG   A N   1 
ATOM   1524 C  CA  . ARG   A 1 189 ? -32.66531 11.29143 0.41689   1.000 22.50585 ? 189 ARG   A CA  1 
ATOM   1525 C  C   . ARG   A 1 189 ? -34.07495 10.78781 0.70147   1.000 20.07454 ? 189 ARG   A C   1 
ATOM   1526 O  O   . ARG   A 1 189 ? -34.70380 10.16211 -0.15884  1.000 18.68949 ? 189 ARG   A O   1 
ATOM   1527 C  CB  . ARG   A 1 189 ? -31.63191 10.32285 0.99035   1.000 22.09068 ? 189 ARG   A CB  1 
ATOM   1528 C  CG  . ARG   A 1 189 ? -31.79969 8.88326  0.49815   1.000 20.79520 ? 189 ARG   A CG  1 
ATOM   1529 C  CD  . ARG   A 1 189 ? -31.57930 8.76250  -1.00701  1.000 19.02648 ? 189 ARG   A CD  1 
ATOM   1530 N  NE  . ARG   A 1 189 ? -30.16640 8.84509  -1.35280  1.000 23.25762 ? 189 ARG   A NE  1 
ATOM   1531 C  CZ  . ARG   A 1 189 ? -29.67752 9.54204  -2.38136  1.000 23.21018 ? 189 ARG   A CZ  1 
ATOM   1532 N  NH1 . ARG   A 1 189 ? -30.49085 10.22289 -3.17981  1.000 16.48509 ? 189 ARG   A NH1 1 
ATOM   1533 N  NH2 . ARG   A 1 189 ? -28.37045 9.55934  -2.61338  1.000 19.14938 ? 189 ARG   A NH2 1 
ATOM   1534 N  N   . LYS   A 1 190 ? -34.59567 11.05912 1.90113   1.000 23.30773 ? 190 LYS   A N   1 
ATOM   1535 C  CA  . LYS   A 1 190 ? -35.90040 10.51434 2.27456   1.000 21.03253 ? 190 LYS   A CA  1 
ATOM   1536 C  C   . LYS   A 1 190 ? -37.00668 11.05121 1.37485   1.000 22.69373 ? 190 LYS   A C   1 
ATOM   1537 O  O   . LYS   A 1 190 ? -37.84742 10.28771 0.89074   1.000 25.36012 ? 190 LYS   A O   1 
ATOM   1538 C  CB  . LYS   A 1 190 ? -36.20022 10.82145 3.74189   1.000 27.03181 ? 190 LYS   A CB  1 
ATOM   1539 C  CG  . LYS   A 1 190 ? -37.62864 10.52272 4.17792   1.000 27.49071 ? 190 LYS   A CG  1 
ATOM   1540 C  CD  . LYS   A 1 190 ? -37.84960 10.90769 5.64262   1.000 32.70873 ? 190 LYS   A CD  1 
ATOM   1541 C  CE  . LYS   A 1 190 ? -39.29225 10.64662 6.07842   1.000 31.62558 ? 190 LYS   A CE  1 
ATOM   1542 N  NZ  . LYS   A 1 190 ? -39.53903 11.08850 7.47530   1.000 38.63994 ? 190 LYS   A NZ  1 
ATOM   1543 N  N   . TYR   A 1 191 ? -37.02434 12.36557 1.13353   1.000 26.51515 ? 191 TYR   A N   1 
ATOM   1544 C  CA  . TYR   A 1 191 ? -38.12567 12.98125 0.39989   1.000 20.96513 ? 191 TYR   A CA  1 
ATOM   1545 C  C   . TYR   A 1 191 ? -37.89266 13.03613 -1.10104  1.000 25.41654 ? 191 TYR   A C   1 
ATOM   1546 O  O   . TYR   A 1 191 ? -38.84898 13.28954 -1.84600  1.000 22.13160 ? 191 TYR   A O   1 
ATOM   1547 C  CB  . TYR   A 1 191 ? -38.40037 14.39541 0.93757   1.000 19.23197 ? 191 TYR   A CB  1 
ATOM   1548 C  CG  . TYR   A 1 191 ? -38.89070 14.35731 2.37034   1.000 21.70752 ? 191 TYR   A CG  1 
ATOM   1549 C  CD1 . TYR   A 1 191 ? -40.15597 13.85231 2.67781   1.000 22.59215 ? 191 TYR   A CD1 1 
ATOM   1550 C  CD2 . TYR   A 1 191 ? -38.07916 14.77449 3.42021   1.000 23.63670 ? 191 TYR   A CD2 1 
ATOM   1551 C  CE1 . TYR   A 1 191 ? -40.60745 13.78006 3.98881   1.000 22.45124 ? 191 TYR   A CE1 1 
ATOM   1552 C  CE2 . TYR   A 1 191 ? -38.52085 14.70638 4.74481   1.000 26.35108 ? 191 TYR   A CE2 1 
ATOM   1553 C  CZ  . TYR   A 1 191 ? -39.78904 14.20771 5.01727   1.000 29.08260 ? 191 TYR   A CZ  1 
ATOM   1554 O  OH  . TYR   A 1 191 ? -40.24187 14.14019 6.31646   1.000 32.28822 ? 191 TYR   A OH  1 
ATOM   1555 N  N   . GLY   A 1 192 ? -36.66416 12.78990 -1.56441  1.000 22.66330 ? 192 GLY   A N   1 
ATOM   1556 C  CA  . GLY   A 1 192 ? -36.36867 12.89442 -2.98020  1.000 20.12933 ? 192 GLY   A CA  1 
ATOM   1557 C  C   . GLY   A 1 192 ? -36.18767 11.56562 -3.67946  1.000 24.74510 ? 192 GLY   A C   1 
ATOM   1558 O  O   . GLY   A 1 192 ? -36.22912 11.50351 -4.91412  1.000 24.96982 ? 192 GLY   A O   1 
ATOM   1559 N  N   . GLY   A 1 193 ? -35.98877 10.49601 -2.90665  1.000 19.53019 ? 193 GLY   A N   1 
ATOM   1560 C  CA  . GLY   A 1 193 ? -35.74904 9.18913  -3.48139  1.000 21.12999 ? 193 GLY   A CA  1 
ATOM   1561 C  C   . GLY   A 1 193 ? -34.29206 8.97795  -3.85510  1.000 28.79543 ? 193 GLY   A C   1 
ATOM   1562 O  O   . GLY   A 1 193 ? -33.41801 9.82363  -3.64019  1.000 24.00080 ? 193 GLY   A O   1 
ATOM   1563 N  N   . ASP   A 1 194 ? -34.04093 7.80818  -4.45106  1.000 25.78255 ? 194 ASP   A N   1 
ATOM   1564 C  CA  . ASP   A 1 194 ? -32.69745 7.32783  -4.75463  1.000 31.46357 ? 194 ASP   A CA  1 
ATOM   1565 C  C   . ASP   A 1 194 ? -32.11311 7.91385  -6.03211  1.000 29.71913 ? 194 ASP   A C   1 
ATOM   1566 O  O   . ASP   A 1 194 ? -30.90429 7.78393  -6.25123  1.000 26.96058 ? 194 ASP   A O   1 
ATOM   1567 C  CB  . ASP   A 1 194 ? -32.70106 5.79783  -4.86746  1.000 31.51416 ? 194 ASP   A CB  1 
ATOM   1568 C  CG  . ASP   A 1 194 ? -32.98468 5.12178  -3.54541  1.000 37.74459 ? 194 ASP   A CG  1 
ATOM   1569 O  OD1 . ASP   A 1 194 ? -32.09522 5.15281  -2.66709  1.000 42.35437 ? 194 ASP   A OD1 1 
ATOM   1570 O  OD2 . ASP   A 1 194 ? -34.09857 4.57386  -3.37965  1.000 50.83463 ? 194 ASP   A OD2 1 
ATOM   1571 N  N   . ASN   A 1 195 ? -32.93124 8.54601  -6.87101  1.000 28.32068 ? 195 ASN   A N   1 
ATOM   1572 C  CA  . ASN   A 1 195 ? -32.47852 9.01255  -8.17420  1.000 30.21723 ? 195 ASN   A CA  1 
ATOM   1573 C  C   . ASN   A 1 195 ? -31.87832 10.41833 -8.16110  1.000 25.90451 ? 195 ASN   A C   1 
ATOM   1574 O  O   . ASN   A 1 195 ? -31.17308 10.77149 -9.11074  1.000 32.03750 ? 195 ASN   A O   1 
ATOM   1575 C  CB  . ASN   A 1 195 ? -33.63664 8.94844  -9.16846  1.000 32.02409 ? 195 ASN   A CB  1 
ATOM   1576 C  CG  . ASN   A 1 195 ? -34.20771 7.53911  -9.29724  1.000 40.70475 ? 195 ASN   A CG  1 
ATOM   1577 O  OD1 . ASN   A 1 195 ? -35.37781 7.35712  -9.64585  1.000 45.05564 ? 195 ASN   A OD1 1 
ATOM   1578 N  ND2 . ASN   A 1 195 ? -33.37696 6.53360  -9.02043  1.000 35.78620 ? 195 ASN   A ND2 1 
ATOM   1579 N  N   . ILE   A 1 196 ? -32.12904 11.23554 -7.12701  1.000 20.70596 ? 196 ILE   A N   1 
ATOM   1580 C  CA  . ILE   A 1 196 ? -31.45026 12.52564 -7.03373  1.000 19.42349 ? 196 ILE   A CA  1 
ATOM   1581 C  C   . ILE   A 1 196 ? -30.07077 12.31400 -6.41886  1.000 20.78462 ? 196 ILE   A C   1 
ATOM   1582 O  O   . ILE   A 1 196 ? -29.85348 11.40527 -5.60803  1.000 16.02346 ? 196 ILE   A O   1 
ATOM   1583 C  CB  . ILE   A 1 196 ? -32.27429 13.56426 -6.23850  1.000 18.63950 ? 196 ILE   A CB  1 
ATOM   1584 C  CG1 . ILE   A 1 196 ? -32.42780 13.16424 -4.76852  1.000 15.09630 ? 196 ILE   A CG1 1 
ATOM   1585 C  CG2 . ILE   A 1 196 ? -33.64411 13.78504 -6.87988  1.000 16.55345 ? 196 ILE   A CG2 1 
ATOM   1586 C  CD1 . ILE   A 1 196 ? -33.00497 14.28014 -3.90510  1.000 20.15337 ? 196 ILE   A CD1 1 
ATOM   1587 N  N   . LYS   A 1 197 ? -29.12328 13.15555 -6.82250  1.000 17.34325 ? 197 LYS   A N   1 
ATOM   1588 C  CA  . LYS   A 1 197 ? -27.73154 13.04400 -6.41488  1.000 15.15395 ? 197 LYS   A CA  1 
ATOM   1589 C  C   . LYS   A 1 197 ? -27.39813 14.17515 -5.45114  1.000 17.21696 ? 197 LYS   A C   1 
ATOM   1590 O  O   . LYS   A 1 197 ? -27.65681 15.34789 -5.75034  1.000 15.25408 ? 197 LYS   A O   1 
ATOM   1591 C  CB  . LYS   A 1 197 ? -26.81342 13.07195 -7.63981  1.000 17.34056 ? 197 LYS   A CB  1 
ATOM   1592 C  CG  . LYS   A 1 197 ? -27.14721 12.00208 -8.65751  1.000 19.05117 ? 197 LYS   A CG  1 
ATOM   1593 C  CD  . LYS   A 1 197 ? -26.72531 10.62808 -8.14943  1.000 20.40248 ? 197 LYS   A CD  1 
ATOM   1594 C  CE  . LYS   A 1 197 ? -27.38367 9.50908  -8.95115  1.000 35.20497 ? 197 LYS   A CE  1 
ATOM   1595 N  NZ  . LYS   A 1 197 ? -26.84144 8.17357  -8.56743  1.000 36.92090 ? 197 LYS   A NZ  1 
ATOM   1596 N  N   . LEU   A 1 198 ? -26.82468 13.81411 -4.30121  1.000 16.46245 ? 198 LEU   A N   1 
ATOM   1597 C  CA  . LEU   A 1 198 ? -26.62396 14.71801 -3.17325  1.000 19.42838 ? 198 LEU   A CA  1 
ATOM   1598 C  C   . LEU   A 1 198 ? -25.15916 15.11243 -3.06491  1.000 17.64060 ? 198 LEU   A C   1 
ATOM   1599 O  O   . LEU   A 1 198 ? -24.28608 14.24163 -3.02437  1.000 17.99475 ? 198 LEU   A O   1 
ATOM   1600 C  CB  . LEU   A 1 198 ? -27.08621 14.05900 -1.87179  1.000 16.60120 ? 198 LEU   A CB  1 
ATOM   1601 C  CG  . LEU   A 1 198 ? -28.47315 13.42849 -2.01766  1.000 18.55741 ? 198 LEU   A CG  1 
ATOM   1602 C  CD1 . LEU   A 1 198 ? -28.97747 12.90840 -0.67086  1.000 13.82210 ? 198 LEU   A CD1 1 
ATOM   1603 C  CD2 . LEU   A 1 198 ? -29.46458 14.43154 -2.62165  1.000 14.22471 ? 198 LEU   A CD2 1 
ATOM   1604 N  N   . TYR   A 1 199 ? -24.89647 16.41932 -2.98429  1.000 13.48450 ? 199 TYR   A N   1 
ATOM   1605 C  CA  . TYR   A 1 199 ? -23.53752 16.94081 -3.00580  1.000 14.18093 ? 199 TYR   A CA  1 
ATOM   1606 C  C   . TYR   A 1 199 ? -23.24586 17.80657 -1.79059  1.000 16.04725 ? 199 TYR   A C   1 
ATOM   1607 O  O   . TYR   A 1 199 ? -24.12333 18.51575 -1.27680  1.000 14.51564 ? 199 TYR   A O   1 
ATOM   1608 C  CB  . TYR   A 1 199 ? -23.27413 17.76803 -4.27676  1.000 16.13696 ? 199 TYR   A CB  1 
ATOM   1609 C  CG  . TYR   A 1 199 ? -23.24897 16.91043 -5.50210  1.000 14.18208 ? 199 TYR   A CG  1 
ATOM   1610 C  CD1 . TYR   A 1 199 ? -24.43715 16.46647 -6.07385  1.000 14.36093 ? 199 TYR   A CD1 1 
ATOM   1611 C  CD2 . TYR   A 1 199 ? -22.04090 16.50660 -6.07065  1.000 12.08215 ? 199 TYR   A CD2 1 
ATOM   1612 C  CE1 . TYR   A 1 199 ? -24.43658 15.64687 -7.17547  1.000 14.81730 ? 199 TYR   A CE1 1 
ATOM   1613 C  CE2 . TYR   A 1 199 ? -22.02466 15.68619 -7.17826  1.000 14.66419 ? 199 TYR   A CE2 1 
ATOM   1614 C  CZ  . TYR   A 1 199 ? -23.23077 15.26069 -7.72641  1.000 16.98193 ? 199 TYR   A CZ  1 
ATOM   1615 O  OH  . TYR   A 1 199 ? -23.25653 14.45344 -8.82911  1.000 14.11224 ? 199 TYR   A OH  1 
ATOM   1616 N  N   . MET   A 1 200 ? -21.98976 17.74157 -1.34487  1.000 14.72353 ? 200 MET   A N   1 
ATOM   1617 C  CA  . MET   A 1 200 ? -21.41285 18.71841 -0.42737  1.000 17.73943 ? 200 MET   A CA  1 
ATOM   1618 C  C   . MET   A 1 200 ? -20.56476 19.67494 -1.26105  1.000 16.43897 ? 200 MET   A C   1 
ATOM   1619 O  O   . MET   A 1 200 ? -19.65792 19.23445 -1.97318  1.000 16.13068 ? 200 MET   A O   1 
ATOM   1620 C  CB  . MET   A 1 200 ? -20.56673 18.03174 0.64522   1.000 13.70810 ? 200 MET   A CB  1 
ATOM   1621 C  CG  . MET   A 1 200 ? -19.96293 18.97333 1.67308   1.000 15.39889 ? 200 MET   A CG  1 
ATOM   1622 S  SD  . MET   A 1 200 ? -18.97685 18.11152 2.93479   1.000 21.46986 ? 200 MET   A SD  1 
ATOM   1623 C  CE  . MET   A 1 200 ? -20.24437 17.15204 3.75359   1.000 17.79845 ? 200 MET   A CE  1 
ATOM   1624 N  N   . ASN   A 1 201 ? -20.86156 20.97013 -1.17907  1.000 12.80891 ? 201 ASN   A N   1 
ATOM   1625 C  CA  . ASN   A 1 201 ? -20.25898 21.99218 -2.03215  1.000 13.32839 ? 201 ASN   A CA  1 
ATOM   1626 C  C   . ASN   A 1 201 ? -19.37454 22.91562 -1.19229  1.000 16.55455 ? 201 ASN   A C   1 
ATOM   1627 O  O   . ASN   A 1 201 ? -19.70106 23.21816 -0.03836  1.000 16.05300 ? 201 ASN   A O   1 
ATOM   1628 C  CB  . ASN   A 1 201 ? -21.37941 22.78466 -2.74477  1.000 13.81497 ? 201 ASN   A CB  1 
ATOM   1629 C  CG  . ASN   A 1 201 ? -20.87851 23.65166 -3.89827  1.000 16.43680 ? 201 ASN   A CG  1 
ATOM   1630 O  OD1 . ASN   A 1 201 ? -20.24254 23.16859 -4.83474  1.000 15.54454 ? 201 ASN   A OD1 1 
ATOM   1631 N  ND2 . ASN   A 1 201 ? -21.18699 24.94081 -3.83731  1.000 12.65099 ? 201 ASN   A ND2 1 
ATOM   1632 N  N   . ASP   A 1 202 ? -18.25175 23.36436 -1.75771  1.000 14.96812 ? 202 ASP   A N   1 
ATOM   1633 C  CA  . ASP   A 1 202 ? -17.34681 24.23338 -1.01087  1.000 14.99089 ? 202 ASP   A CA  1 
ATOM   1634 C  C   . ASP   A 1 202 ? -16.36078 24.91359 -1.95997  1.000 16.24074 ? 202 ASP   A C   1 
ATOM   1635 O  O   . ASP   A 1 202 ? -16.21153 24.52751 -3.11995  1.000 16.88424 ? 202 ASP   A O   1 
ATOM   1636 C  CB  . ASP   A 1 202 ? -16.58935 23.44893 0.07208   1.000 12.63988 ? 202 ASP   A CB  1 
ATOM   1637 C  CG  . ASP   A 1 202 ? -16.53651 24.19533 1.38715   1.000 15.32898 ? 202 ASP   A CG  1 
ATOM   1638 O  OD1 . ASP   A 1 202 ? -16.34952 25.42719 1.33657   1.000 15.44938 ? 202 ASP   A OD1 1 
ATOM   1639 O  OD2 . ASP   A 1 202 ? -16.71604 23.56629 2.45737   1.000 16.00298 ? 202 ASP   A OD2 1 
ATOM   1640 N  N   . TYR   A 1 203 ? -15.68181 25.93921 -1.44720  1.000 17.16098 ? 203 TYR   A N   1 
ATOM   1641 C  CA  . TYR   A 1 203 ? -14.59598 26.59973 -2.16174  1.000 15.57168 ? 203 TYR   A CA  1 
ATOM   1642 C  C   . TYR   A 1 203 ? -13.27452 26.17946 -1.54033  1.000 16.94708 ? 203 TYR   A C   1 
ATOM   1643 O  O   . TYR   A 1 203 ? -13.22986 25.71355 -0.39628  1.000 16.92154 ? 203 TYR   A O   1 
ATOM   1644 C  CB  . TYR   A 1 203 ? -14.73090 28.13014 -2.11580  1.000 16.61208 ? 203 TYR   A CB  1 
ATOM   1645 C  CG  . TYR   A 1 203 ? -14.65691 28.72335 -0.71832  1.000 16.26031 ? 203 TYR   A CG  1 
ATOM   1646 C  CD1 . TYR   A 1 203 ? -15.79674 28.81998 0.08750   1.000 15.43506 ? 203 TYR   A CD1 1 
ATOM   1647 C  CD2 . TYR   A 1 203 ? -13.44406 29.18154 -0.20195  1.000 18.39298 ? 203 TYR   A CD2 1 
ATOM   1648 C  CE1 . TYR   A 1 203 ? -15.73325 29.36491 1.36886   1.000 16.93739 ? 203 TYR   A CE1 1 
ATOM   1649 C  CE2 . TYR   A 1 203 ? -13.35981 29.72458 1.07734   1.000 15.45306 ? 203 TYR   A CE2 1 
ATOM   1650 C  CZ  . TYR   A 1 203 ? -14.50458 29.81660 1.86226   1.000 22.10020 ? 203 TYR   A CZ  1 
ATOM   1651 O  OH  . TYR   A 1 203 ? -14.40371 30.34767 3.13943   1.000 19.71759 ? 203 TYR   A OH  1 
ATOM   1652 N  N   . ASN   A 1 204 ? -12.19442 26.34783 -2.30620  1.000 18.11321 ? 204 ASN   A N   1 
ATOM   1653 C  CA  . ASN   A 1 204 ? -10.84528 26.01762 -1.83623  1.000 16.49515 ? 204 ASN   A CA  1 
ATOM   1654 C  C   . ASN   A 1 204 ? -10.76345 24.54806 -1.41701  1.000 16.20699 ? 204 ASN   A C   1 
ATOM   1655 O  O   . ASN   A 1 204 ? -10.07760 24.18780 -0.45874  1.000 15.94563 ? 204 ASN   A O   1 
ATOM   1656 C  CB  . ASN   A 1 204 ? -10.40923 26.94520 -0.69330  1.000 13.07709 ? 204 ASN   A CB  1 
ATOM   1657 C  CG  . ASN   A 1 204 ? -10.02117 28.34962 -1.17429  1.000 18.13233 ? 204 ASN   A CG  1 
ATOM   1658 O  OD1 . ASN   A 1 204 ? -10.21341 28.71092 -2.34000  1.000 15.54624 ? 204 ASN   A OD1 1 
ATOM   1659 N  ND2 . ASN   A 1 204 ? -9.46670  29.14545 -0.26724  1.000 18.82703 ? 204 ASN   A ND2 1 
ATOM   1660 N  N   . THR   A 1 205 ? -11.46794 23.68415 -2.15407  1.000 17.59284 ? 205 THR   A N   1 
ATOM   1661 C  CA  . THR   A 1 205 ? -11.38921 22.25243 -1.89673  1.000 17.77470 ? 205 THR   A CA  1 
ATOM   1662 C  C   . THR   A 1 205 ? -9.99060  21.70838 -2.16935  1.000 20.67197 ? 205 THR   A C   1 
ATOM   1663 O  O   . THR   A 1 205 ? -9.65725  20.60292 -1.72060  1.000 17.94379 ? 205 THR   A O   1 
ATOM   1664 C  CB  . THR   A 1 205 ? -12.41679 21.50213 -2.74607  1.000 15.56317 ? 205 THR   A CB  1 
ATOM   1665 O  OG1 . THR   A 1 205 ? -12.24197 21.85294 -4.12159  1.000 16.93559 ? 205 THR   A OG1 1 
ATOM   1666 C  CG2 . THR   A 1 205 ? -13.85331 21.84942 -2.32184  1.000 15.10727 ? 205 THR   A CG2 1 
ATOM   1667 N  N   . GLU   A 1 206 ? -9.17422  22.46247 -2.89261  1.000 16.70456 ? 206 GLU   A N   1 
ATOM   1668 C  CA  . GLU   A 1 206 ? -7.81360  22.07984 -3.23362  1.000 20.11114 ? 206 GLU   A CA  1 
ATOM   1669 C  C   . GLU   A 1 206 ? -6.80313  22.40307 -2.14332  1.000 22.00664 ? 206 GLU   A C   1 
ATOM   1670 O  O   . GLU   A 1 206 ? -5.64906  21.98270 -2.25891  1.000 27.49517 ? 206 GLU   A O   1 
ATOM   1671 C  CB  . GLU   A 1 206 ? -7.38015  22.79312 -4.52818  1.000 20.62626 ? 206 GLU   A CB  1 
ATOM   1672 C  CG  . GLU   A 1 206 ? -8.38260  22.76274 -5.68369  1.000 20.01624 ? 206 GLU   A CG  1 
ATOM   1673 C  CD  . GLU   A 1 206 ? -9.49787  23.80309 -5.56111  1.000 21.34568 ? 206 GLU   A CD  1 
ATOM   1674 O  OE1 . GLU   A 1 206 ? -9.42403  24.68467 -4.66541  1.000 15.93539 ? 206 GLU   A OE1 1 
ATOM   1675 O  OE2 . GLU   A 1 206 ? -10.45486 23.72780 -6.36913  1.000 17.75193 ? 206 GLU   A OE2 1 
ATOM   1676 N  N   . VAL   A 1 207 ? -7.19619  23.12682 -1.09835  1.000 20.98817 ? 207 VAL   A N   1 
ATOM   1677 C  CA  . VAL   A 1 207 ? -6.26311  23.80858 -0.20223  1.000 22.71657 ? 207 VAL   A CA  1 
ATOM   1678 C  C   . VAL   A 1 207 ? -6.23511  23.10832 1.15069   1.000 24.18858 ? 207 VAL   A C   1 
ATOM   1679 O  O   . VAL   A 1 207 ? -7.29130  22.86413 1.75105   1.000 20.09090 ? 207 VAL   A O   1 
ATOM   1680 C  CB  . VAL   A 1 207 ? -6.64690  25.29146 -0.04439  1.000 22.30374 ? 207 VAL   A CB  1 
ATOM   1681 C  CG1 . VAL   A 1 207 ? -5.54721  26.06121 0.67136   1.000 26.60384 ? 207 VAL   A CG1 1 
ATOM   1682 C  CG2 . VAL   A 1 207 ? -6.89789  25.88771 -1.39625  1.000 22.86579 ? 207 VAL   A CG2 1 
ATOM   1683 N  N   . GLU   A 1 208 ? -5.00628  22.79748 1.64471   1.000 20.11220 ? 208 GLU   A N   1 
ATOM   1684 C  CA  . GLU   A 1 208 ? -4.86276  22.24719 2.98991   1.000 22.83443 ? 208 GLU   A CA  1 
ATOM   1685 C  C   . GLU   A 1 208 ? -4.82781  23.36870 4.03042   1.000 21.83087 ? 208 GLU   A C   1 
ATOM   1686 O  O   . GLU   A 1 208 ? -4.34253  24.46968 3.75679   1.000 21.58448 ? 208 GLU   A O   1 
ATOM   1687 C  CB  . GLU   A 1 208 ? -3.59405  21.39809 3.10603   1.000 22.54661 ? 208 GLU   A CB  1 
ATOM   1688 C  CG  . GLU   A 1 208 ? -3.55857  20.15556 2.21064   1.000 21.68471 ? 208 GLU   A CG  1 
ATOM   1689 C  CD  . GLU   A 1 208 ? -4.62513  19.11646 2.56591   1.000 23.43593 ? 208 GLU   A CD  1 
ATOM   1690 O  OE1 . GLU   A 1 208 ? -5.32724  19.27705 3.58803   1.000 27.86101 ? 208 GLU   A OE1 1 
ATOM   1691 O  OE2 . GLU   A 1 208 ? -4.76020  18.13053 1.81116   1.000 30.30240 ? 208 GLU   A OE2 1 
ATOM   1692 N  N   . PRO   A 1 209 ? -5.32438  23.11300 5.24979   1.000 22.29694 ? 209 PRO   A N   1 
ATOM   1693 C  CA  . PRO   A 1 209 ? -5.87846  21.86049 5.77789   1.000 22.42767 ? 209 PRO   A CA  1 
ATOM   1694 C  C   . PRO   A 1 209 ? -7.35203  21.57042 5.42535   1.000 24.49743 ? 209 PRO   A C   1 
ATOM   1695 O  O   . PRO   A 1 209 ? -7.85802  20.50142 5.79292   1.000 24.55580 ? 209 PRO   A O   1 
ATOM   1696 C  CB  . PRO   A 1 209 ? -5.72212  22.04736 7.28563   1.000 25.30970 ? 209 PRO   A CB  1 
ATOM   1697 C  CG  . PRO   A 1 209 ? -5.92705  23.52346 7.48037   1.000 22.38117 ? 209 PRO   A CG  1 
ATOM   1698 C  CD  . PRO   A 1 209 ? -5.25304  24.16015 6.28662   1.000 22.44310 ? 209 PRO   A CD  1 
ATOM   1699 N  N   . LYS   A 1 210 ? -8.01857  22.49347 4.72193   1.000 25.39552 ? 210 LYS   A N   1 
ATOM   1700 C  CA  . LYS   A 1 210 ? -9.43464  22.31494 4.39114   1.000 22.65189 ? 210 LYS   A CA  1 
ATOM   1701 C  C   . LYS   A 1 210 ? -9.68332  21.04319 3.57609   1.000 20.28522 ? 210 LYS   A C   1 
ATOM   1702 O  O   . LYS   A 1 210 ? -10.66405 20.32774 3.81208   1.000 18.09103 ? 210 LYS   A O   1 
ATOM   1703 C  CB  . LYS   A 1 210 ? -9.94291  23.54511 3.63691   1.000 19.81530 ? 210 LYS   A CB  1 
ATOM   1704 C  CG  . LYS   A 1 210 ? -11.42339 23.50825 3.25688   1.000 21.80434 ? 210 LYS   A CG  1 
ATOM   1705 C  CD  . LYS   A 1 210 ? -11.81420 24.77350 2.50854   1.000 21.29759 ? 210 LYS   A CD  1 
ATOM   1706 C  CE  . LYS   A 1 210 ? -13.19345 25.28741 2.91275   1.000 18.52464 ? 210 LYS   A CE  1 
ATOM   1707 N  NZ  . LYS   A 1 210 ? -13.51318 26.60745 2.28882   1.000 17.98205 ? 210 LYS   A NZ  1 
ATOM   1708 N  N   . ARG   A 1 211 ? -8.80935  20.74654 2.61369   1.000 21.55613 ? 211 ARG   A N   1 
ATOM   1709 C  CA  . ARG   A 1 211 ? -9.02079  19.59453 1.74082   1.000 20.51281 ? 211 ARG   A CA  1 
ATOM   1710 C  C   . ARG   A 1 211 ? -9.10414  18.29594 2.53538   1.000 23.98303 ? 211 ARG   A C   1 
ATOM   1711 O  O   . ARG   A 1 211 ? -10.02535 17.49518 2.34420   1.000 24.09999 ? 211 ARG   A O   1 
ATOM   1712 C  CB  . ARG   A 1 211 ? -7.89845  19.50262 0.70486   1.000 20.30632 ? 211 ARG   A CB  1 
ATOM   1713 C  CG  . ARG   A 1 211 ? -7.97174  18.23487 -0.16377  1.000 22.89593 ? 211 ARG   A CG  1 
ATOM   1714 C  CD  . ARG   A 1 211 ? -7.00304  18.29309 -1.35568  1.000 20.94510 ? 211 ARG   A CD  1 
ATOM   1715 N  NE  . ARG   A 1 211 ? -5.59931  18.33074 -0.94758  1.000 21.17355 ? 211 ARG   A NE  1 
ATOM   1716 C  CZ  . ARG   A 1 211 ? -4.59478  18.63754 -1.76423  1.000 25.69534 ? 211 ARG   A CZ  1 
ATOM   1717 N  NH1 . ARG   A 1 211 ? -4.83576  18.94141 -3.04006  1.000 21.17916 ? 211 ARG   A NH1 1 
ATOM   1718 N  NH2 . ARG   A 1 211 ? -3.34592  18.64360 -1.31109  1.000 23.37289 ? 211 ARG   A NH2 1 
ATOM   1719 N  N   . THR   A 1 212 ? -8.13506  18.05769 3.41912   1.000 23.31073 ? 212 THR   A N   1 
ATOM   1720 C  CA  . THR   A 1 212 ? -8.13852  16.81758 4.18590   1.000 22.59237 ? 212 THR   A CA  1 
ATOM   1721 C  C   . THR   A 1 212 ? -9.28442  16.80323 5.18972   1.000 24.55766 ? 212 THR   A C   1 
ATOM   1722 O  O   . THR   A 1 212 ? -9.88313  15.74897 5.44033   1.000 22.96347 ? 212 THR   A O   1 
ATOM   1723 C  CB  . THR   A 1 212 ? -6.78008  16.63030 4.86983   1.000 26.01529 ? 212 THR   A CB  1 
ATOM   1724 O  OG1 . THR   A 1 212 ? -5.77816  16.51433 3.85678   1.000 29.74111 ? 212 THR   A OG1 1 
ATOM   1725 C  CG2 . THR   A 1 212 ? -6.75358  15.35457 5.71327   1.000 23.46802 ? 212 THR   A CG2 1 
ATOM   1726 N  N   . ALA   A 1 213 ? -9.62499  17.97200 5.75020   1.000 25.23947 ? 213 ALA   A N   1 
ATOM   1727 C  CA  . ALA   A 1 213 ? -10.77036 18.05688 6.65474   1.000 21.95582 ? 213 ALA   A CA  1 
ATOM   1728 C  C   . ALA   A 1 213 ? -12.06463 17.70175 5.93012   1.000 23.79298 ? 213 ALA   A C   1 
ATOM   1729 O  O   . ALA   A 1 213 ? -12.91599 16.97971 6.47104   1.000 20.91461 ? 213 ALA   A O   1 
ATOM   1730 C  CB  . ALA   A 1 213 ? -10.86048 19.45749 7.26237   1.000 17.77428 ? 213 ALA   A CB  1 
ATOM   1731 N  N   . LEU   A 1 214 ? -12.22153 18.19256 4.69804   1.000 20.65478 ? 214 LEU   A N   1 
ATOM   1732 C  CA  . LEU   A 1 214 ? -13.35815 17.79799 3.87026   1.000 19.69226 ? 214 LEU   A CA  1 
ATOM   1733 C  C   . LEU   A 1 214 ? -13.34035 16.29537 3.59529   1.000 19.81024 ? 214 LEU   A C   1 
ATOM   1734 O  O   . LEU   A 1 214 ? -14.35946 15.60627 3.73784   1.000 21.30120 ? 214 LEU   A O   1 
ATOM   1735 C  CB  . LEU   A 1 214 ? -13.32521 18.59517 2.57095   1.000 18.50164 ? 214 LEU   A CB  1 
ATOM   1736 C  CG  . LEU   A 1 214 ? -14.58183 18.68149 1.72345   1.000 30.08348 ? 214 LEU   A CG  1 
ATOM   1737 C  CD1 . LEU   A 1 214 ? -15.69269 19.31348 2.52036   1.000 26.08713 ? 214 LEU   A CD1 1 
ATOM   1738 C  CD2 . LEU   A 1 214 ? -14.30680 19.49713 0.46309   1.000 27.03214 ? 214 LEU   A CD2 1 
ATOM   1739 N  N   . TYR   A 1 215 ? -12.17274 15.77161 3.22184   1.000 23.39934 ? 215 TYR   A N   1 
ATOM   1740 C  CA  . TYR   A 1 215 ? -12.00501 14.34228 2.96445   1.000 23.24395 ? 215 TYR   A CA  1 
ATOM   1741 C  C   . TYR   A 1 215 ? -12.40800 13.49737 4.17429   1.000 24.49021 ? 215 TYR   A C   1 
ATOM   1742 O  O   . TYR   A 1 215 ? -13.19619 12.55046 4.05797   1.000 22.53100 ? 215 TYR   A O   1 
ATOM   1743 C  CB  . TYR   A 1 215 ? -10.54681 14.08003 2.58520   1.000 23.47134 ? 215 TYR   A CB  1 
ATOM   1744 C  CG  . TYR   A 1 215 ? -10.22843 12.63886 2.28358   1.000 29.47869 ? 215 TYR   A CG  1 
ATOM   1745 C  CD1 . TYR   A 1 215 ? -10.37393 12.13196 0.99725   1.000 27.80260 ? 215 TYR   A CD1 1 
ATOM   1746 C  CD2 . TYR   A 1 215 ? -9.77256  11.78408 3.28093   1.000 25.12528 ? 215 TYR   A CD2 1 
ATOM   1747 C  CE1 . TYR   A 1 215 ? -10.07414 10.81565 0.71093   1.000 30.15090 ? 215 TYR   A CE1 1 
ATOM   1748 C  CE2 . TYR   A 1 215 ? -9.48007  10.46612 3.00757   1.000 26.72381 ? 215 TYR   A CE2 1 
ATOM   1749 C  CZ  . TYR   A 1 215 ? -9.63277  9.98426  1.71950   1.000 36.97395 ? 215 TYR   A CZ  1 
ATOM   1750 O  OH  . TYR   A 1 215 ? -9.33771  8.66862  1.42830   1.000 36.62528 ? 215 TYR   A OH  1 
ATOM   1751 N  N   . ASN   A 1 216 ? -11.84990 13.80610 5.34412   1.000 23.14634 ? 216 ASN   A N   1 
ATOM   1752 C  CA  . ASN   A 1 216 ? -12.18767 13.03473 6.53061   1.000 21.81485 ? 216 ASN   A CA  1 
ATOM   1753 C  C   . ASN   A 1 216 ? -13.67489 13.14745 6.85445   1.000 26.71336 ? 216 ASN   A C   1 
ATOM   1754 O  O   . ASN   A 1 216 ? -14.31505 12.15284 7.21787   1.000 21.79686 ? 216 ASN   A O   1 
ATOM   1755 C  CB  . ASN   A 1 216 ? -11.32646 13.49332 7.70467   1.000 20.93453 ? 216 ASN   A CB  1 
ATOM   1756 C  CG  . ASN   A 1 216 ? -9.84929  13.18455 7.49528   1.000 26.97502 ? 216 ASN   A CG  1 
ATOM   1757 O  OD1 . ASN   A 1 216 ? -9.49717  12.28803 6.72919   1.000 29.08114 ? 216 ASN   A OD1 1 
ATOM   1758 N  ND2 . ASN   A 1 216 ? -8.98178  13.92722 8.17405   1.000 23.69961 ? 216 ASN   A ND2 1 
ATOM   1759 N  N   . LEU   A 1 217 ? -14.25632 14.34108 6.68842   1.000 24.78845 ? 217 LEU   A N   1 
ATOM   1760 C  CA  . LEU   A 1 217 ? -15.66275 14.51535 7.03802   1.000 24.24268 ? 217 LEU   A CA  1 
ATOM   1761 C  C   . LEU   A 1 217 ? -16.55462 13.62200 6.18389   1.000 23.66398 ? 217 LEU   A C   1 
ATOM   1762 O  O   . LEU   A 1 217 ? -17.38678 12.87035 6.71026   1.000 27.31266 ? 217 LEU   A O   1 
ATOM   1763 C  CB  . LEU   A 1 217 ? -16.07330 15.98097 6.89720   1.000 28.13532 ? 217 LEU   A CB  1 
ATOM   1764 C  CG  . LEU   A 1 217 ? -17.56694 16.23642 7.09218   1.000 23.17960 ? 217 LEU   A CG  1 
ATOM   1765 C  CD1 . LEU   A 1 217 ? -18.00911 15.89991 8.52314   1.000 25.35674 ? 217 LEU   A CD1 1 
ATOM   1766 C  CD2 . LEU   A 1 217 ? -17.91384 17.66906 6.73410   1.000 20.11866 ? 217 LEU   A CD2 1 
ATOM   1767 N  N   . VAL   A 1 218 ? -16.38605 13.66628 4.85996   1.000 21.71167 ? 218 VAL   A N   1 
ATOM   1768 C  CA  . VAL   A 1 218 ? -17.27478 12.87785 4.01108   1.000 23.17051 ? 218 VAL   A CA  1 
ATOM   1769 C  C   . VAL   A 1 218 ? -16.98899 11.38801 4.18417   1.000 25.03336 ? 218 VAL   A C   1 
ATOM   1770 O  O   . VAL   A 1 218 ? -17.90483 10.55727 4.12080   1.000 24.34820 ? 218 VAL   A O   1 
ATOM   1771 C  CB  . VAL   A 1 218 ? -17.17580 13.33397 2.54204   1.000 22.25292 ? 218 VAL   A CB  1 
ATOM   1772 C  CG1 . VAL   A 1 218 ? -15.74197 13.30376 2.06205   1.000 30.89351 ? 218 VAL   A CG1 1 
ATOM   1773 C  CG2 . VAL   A 1 218 ? -18.01483 12.44725 1.65316   1.000 27.36733 ? 218 VAL   A CG2 1 
ATOM   1774 N  N   . LYS   A 1 219 ? -15.72393 11.02755 4.44576   1.000 30.81581 ? 219 LYS   A N   1 
ATOM   1775 C  CA  . LYS   A 1 219 ? -15.37884 9.62565  4.70766   1.000 28.13361 ? 219 LYS   A CA  1 
ATOM   1776 C  C   . LYS   A 1 219 ? -16.13026 9.09613  5.92294   1.000 24.83067 ? 219 LYS   A C   1 
ATOM   1777 O  O   . LYS   A 1 219 ? -16.73764 8.01981  5.87921   1.000 25.09197 ? 219 LYS   A O   1 
ATOM   1778 C  CB  . LYS   A 1 219 ? -13.86947 9.47870  4.91372   1.000 24.62941 ? 219 LYS   A CB  1 
ATOM   1779 C  CG  . LYS   A 1 219 ? -13.38085 8.03397  4.91664   1.000 29.76939 ? 219 LYS   A CG  1 
ATOM   1780 C  CD  . LYS   A 1 219 ? -11.89448 7.91688  5.24390   1.000 30.51110 ? 219 LYS   A CD  1 
ATOM   1781 C  CE  . LYS   A 1 219 ? -11.37994 6.50920  4.93607   1.000 37.80905 ? 219 LYS   A CE  1 
ATOM   1782 N  NZ  . LYS   A 1 219 ? -10.32362 6.50252  3.86619   1.000 50.33693 ? 219 LYS   A NZ  1 
ATOM   1783 N  N   . GLN   A 1 220 ? -16.10535 9.85188  7.01891   1.000 27.09494 ? 220 GLN   A N   1 
ATOM   1784 C  CA  . GLN   A 1 220 ? -16.79756 9.43033  8.22839   1.000 29.48621 ? 220 GLN   A CA  1 
ATOM   1785 C  C   . GLN   A 1 220 ? -18.30691 9.35927  8.00990   1.000 32.82739 ? 220 GLN   A C   1 
ATOM   1786 O  O   . GLN   A 1 220 ? -18.95580 8.39264  8.43494   1.000 34.03318 ? 220 GLN   A O   1 
ATOM   1787 C  CB  . GLN   A 1 220 ? -16.45400 10.38188 9.37310   1.000 28.47779 ? 220 GLN   A CB  1 
ATOM   1788 C  CG  . GLN   A 1 220 ? -17.23380 10.12382 10.64732  1.000 40.50662 ? 220 GLN   A CG  1 
ATOM   1789 C  CD  . GLN   A 1 220 ? -17.31317 11.35202 11.55287  1.000 51.95903 ? 220 GLN   A CD  1 
ATOM   1790 O  OE1 . GLN   A 1 220 ? -16.29825 11.99633 11.83055  1.000 56.58351 ? 220 GLN   A OE1 1 
ATOM   1791 N  NE2 . GLN   A 1 220 ? -18.52408 11.67266 12.02834  1.000 44.93451 ? 220 GLN   A NE2 1 
ATOM   1792 N  N   . LEU   A 1 221 ? -18.88211 10.36660 7.33754   1.000 27.51717 ? 221 LEU   A N   1 
ATOM   1793 C  CA  . LEU   A 1 221 ? -20.32885 10.38339 7.12275   1.000 29.22416 ? 221 LEU   A CA  1 
ATOM   1794 C  C   . LEU   A 1 221 ? -20.78497 9.17937  6.30691   1.000 27.74610 ? 221 LEU   A C   1 
ATOM   1795 O  O   . LEU   A 1 221 ? -21.79954 8.55314  6.63320   1.000 27.75570 ? 221 LEU   A O   1 
ATOM   1796 C  CB  . LEU   A 1 221 ? -20.75500 11.68458 6.43857   1.000 27.37277 ? 221 LEU   A CB  1 
ATOM   1797 C  CG  . LEU   A 1 221 ? -20.59666 12.94125 7.29076   1.000 28.02367 ? 221 LEU   A CG  1 
ATOM   1798 C  CD1 . LEU   A 1 221 ? -21.02615 14.18240 6.53661   1.000 30.40288 ? 221 LEU   A CD1 1 
ATOM   1799 C  CD2 . LEU   A 1 221 ? -21.38156 12.78755 8.56244   1.000 28.77277 ? 221 LEU   A CD2 1 
ATOM   1800 N  N   . LYS   A 1 222 ? -20.04781 8.83728  5.24547   1.000 25.46826 ? 222 LYS   A N   1 
ATOM   1801 C  CA  . LYS   A 1 222 ? -20.40127 7.66251  4.44888   1.000 30.26595 ? 222 LYS   A CA  1 
ATOM   1802 C  C   . LYS   A 1 222 ? -20.30421 6.38451  5.26723   1.000 36.70714 ? 222 LYS   A C   1 
ATOM   1803 O  O   . LYS   A 1 222 ? -21.13286 5.47631  5.11287   1.000 36.21509 ? 222 LYS   A O   1 
ATOM   1804 C  CB  . LYS   A 1 222 ? -19.50244 7.55710  3.22018   1.000 29.08195 ? 222 LYS   A CB  1 
ATOM   1805 C  CG  . LYS   A 1 222 ? -19.77914 8.60577  2.16571   1.000 26.82575 ? 222 LYS   A CG  1 
ATOM   1806 C  CD  . LYS   A 1 222 ? -19.19436 8.21393  0.83105   1.000 27.19942 ? 222 LYS   A CD  1 
ATOM   1807 C  CE  . LYS   A 1 222 ? -20.11894 7.29469  0.06977   1.000 35.86217 ? 222 LYS   A CE  1 
ATOM   1808 N  NZ  . LYS   A 1 222 ? -19.40843 6.76422  -1.13294  1.000 39.40773 ? 222 LYS   A NZ  1 
ATOM   1809 N  N   . GLU   A 1 223 ? -19.29369 6.29297  6.13935   1.000 32.96365 ? 223 GLU   A N   1 
ATOM   1810 C  CA  . GLU   A 1 223 ? -19.16267 5.11916  6.99618   1.000 32.32745 ? 223 GLU   A CA  1 
ATOM   1811 C  C   . GLU   A 1 223 ? -20.36586 4.97487  7.91895   1.000 34.40552 ? 223 GLU   A C   1 
ATOM   1812 O  O   . GLU   A 1 223 ? -20.79742 3.85378  8.21495   1.000 31.14525 ? 223 GLU   A O   1 
ATOM   1813 C  CB  . GLU   A 1 223 ? -17.87365 5.19932  7.80919   1.000 29.01725 ? 223 GLU   A CB  1 
ATOM   1814 C  CG  . GLU   A 1 223 ? -16.64522 4.74978  7.04461   1.000 36.63565 ? 223 GLU   A CG  1 
ATOM   1815 C  CD  . GLU   A 1 223 ? -15.35043 5.23096  7.68216   1.000 45.44766 ? 223 GLU   A CD  1 
ATOM   1816 O  OE1 . GLU   A 1 223 ? -15.41650 5.94255  8.71745   1.000 44.01769 ? 223 GLU   A OE1 1 
ATOM   1817 O  OE2 . GLU   A 1 223 ? -14.27034 4.89988  7.14040   1.000 38.78056 ? 223 GLU   A OE2 1 
ATOM   1818 N  N   . GLU   A 1 224 ? -20.92248 6.09582  8.38174   1.000 31.57183 ? 224 GLU   A N   1 
ATOM   1819 C  CA  . GLU   A 1 224 ? -22.11792 6.06940  9.21653   1.000 29.52780 ? 224 GLU   A CA  1 
ATOM   1820 C  C   . GLU   A 1 224 ? -23.40202 5.93174  8.41431   1.000 27.86194 ? 224 GLU   A C   1 
ATOM   1821 O  O   . GLU   A 1 224 ? -24.47586 6.03138  9.00683   1.000 34.20629 ? 224 GLU   A O   1 
ATOM   1822 C  CB  . GLU   A 1 224 ? -22.21444 7.33236  10.07156  1.000 28.94346 ? 224 GLU   A CB  1 
ATOM   1823 C  CG  . GLU   A 1 224 ? -21.01857 7.62897  10.94137  1.000 33.27405 ? 224 GLU   A CG  1 
ATOM   1824 C  CD  . GLU   A 1 224 ? -21.27510 8.82354  11.83632  1.000 40.24910 ? 224 GLU   A CD  1 
ATOM   1825 O  OE1 . GLU   A 1 224 ? -22.45223 9.25622  11.90197  1.000 38.70412 ? 224 GLU   A OE1 1 
ATOM   1826 O  OE2 . GLU   A 1 224 ? -20.31392 9.31992  12.46926  1.000 32.84607 ? 224 GLU   A OE2 1 
ATOM   1827 N  N   . GLY   A 1 225 ? -23.32329 5.74050  7.09671   1.000 29.50828 ? 225 GLY   A N   1 
ATOM   1828 C  CA  . GLY   A 1 225 ? -24.50622 5.57338  6.27544   1.000 30.49292 ? 225 GLY   A CA  1 
ATOM   1829 C  C   . GLY   A 1 225 ? -25.20963 6.84960  5.85461   1.000 32.38672 ? 225 GLY   A C   1 
ATOM   1830 O  O   . GLY   A 1 225 ? -26.34495 6.77600  5.36534   1.000 30.42132 ? 225 GLY   A O   1 
ATOM   1831 N  N   . VAL   A 1 226 ? -24.59002 8.01349  6.03187   1.000 29.36892 ? 226 VAL   A N   1 
ATOM   1832 C  CA  . VAL   A 1 226 ? -25.19268 9.25291  5.51861   1.000 26.57808 ? 226 VAL   A CA  1 
ATOM   1833 C  C   . VAL   A 1 226 ? -25.10860 9.24594  3.99746   1.000 25.40951 ? 226 VAL   A C   1 
ATOM   1834 O  O   . VAL   A 1 226 ? -24.02745 8.97785  3.44227   1.000 26.07728 ? 226 VAL   A O   1 
ATOM   1835 C  CB  . VAL   A 1 226 ? -24.49328 10.48015 6.11028   1.000 25.52640 ? 226 VAL   A CB  1 
ATOM   1836 C  CG1 . VAL   A 1 226 ? -25.19092 11.78159 5.67043   1.000 21.56704 ? 226 VAL   A CG1 1 
ATOM   1837 C  CG2 . VAL   A 1 226 ? -24.45034 10.39592 7.62504   1.000 24.12280 ? 226 VAL   A CG2 1 
ATOM   1838 N  N   . PRO   A 1 227 ? -26.20704 9.49282  3.28137   1.000 21.82884 ? 227 PRO   A N   1 
ATOM   1839 C  CA  . PRO   A 1 227 ? -26.16415 9.43279  1.81431   1.000 25.20393 ? 227 PRO   A CA  1 
ATOM   1840 C  C   . PRO   A 1 227 ? -25.50399 10.68208 1.24318   1.000 26.48931 ? 227 PRO   A C   1 
ATOM   1841 O  O   . PRO   A 1 227 ? -25.99927 11.79461 1.40898   1.000 28.68312 ? 227 PRO   A O   1 
ATOM   1842 C  CB  . PRO   A 1 227 ? -27.64961 9.33881  1.42625   1.000 23.43477 ? 227 PRO   A CB  1 
ATOM   1843 C  CG  . PRO   A 1 227 ? -28.37898 9.97670  2.53581   1.000 20.34317 ? 227 PRO   A CG  1 
ATOM   1844 C  CD  . PRO   A 1 227 ? -27.55634 9.79446  3.79106   1.000 23.67882 ? 227 PRO   A CD  1 
ATOM   1845 N  N   . ILE   A 1 228 ? -24.35164 10.49448 0.60912   1.000 23.54918 ? 228 ILE   A N   1 
ATOM   1846 C  CA  . ILE   A 1 228 ? -23.69293 11.59257 -0.08845  1.000 26.55310 ? 228 ILE   A CA  1 
ATOM   1847 C  C   . ILE   A 1 228 ? -23.04639 11.02850 -1.34527  1.000 24.44216 ? 228 ILE   A C   1 
ATOM   1848 O  O   . ILE   A 1 228 ? -22.28892 10.05496 -1.27890  1.000 20.47759 ? 228 ILE   A O   1 
ATOM   1849 C  CB  . ILE   A 1 228 ? -22.66644 12.32895 0.79356   1.000 23.46847 ? 228 ILE   A CB  1 
ATOM   1850 C  CG1 . ILE   A 1 228 ? -21.87108 13.33152 -0.03972  1.000 23.47615 ? 228 ILE   A CG1 1 
ATOM   1851 C  CG2 . ILE   A 1 228 ? -21.76378 11.35667 1.50664   1.000 31.91363 ? 228 ILE   A CG2 1 
ATOM   1852 C  CD1 . ILE   A 1 228 ? -21.17349 14.36369 0.80669   1.000 28.82050 ? 228 ILE   A CD1 1 
ATOM   1853 N  N   . ASP   A 1 229 ? -23.36936 11.61267 -2.49484  1.000 22.83787 ? 229 ASP   A N   1 
ATOM   1854 C  CA  . ASP   A 1 229 ? -22.94681 11.07125 -3.77802  1.000 22.62179 ? 229 ASP   A CA  1 
ATOM   1855 C  C   . ASP   A 1 229 ? -21.74168 11.78309 -4.37294  1.000 19.06765 ? 229 ASP   A C   1 
ATOM   1856 O  O   . ASP   A 1 229 ? -21.03303 11.18338 -5.19168  1.000 18.48347 ? 229 ASP   A O   1 
ATOM   1857 C  CB  . ASP   A 1 229 ? -24.10867 11.13720 -4.77755  1.000 21.35022 ? 229 ASP   A CB  1 
ATOM   1858 C  CG  . ASP   A 1 229 ? -25.35305 10.42675 -4.27164  1.000 23.88371 ? 229 ASP   A CG  1 
ATOM   1859 O  OD1 . ASP   A 1 229 ? -25.28483 9.19737  -4.02715  1.000 25.29078 ? 229 ASP   A OD1 1 
ATOM   1860 O  OD2 . ASP   A 1 229 ? -26.39641 11.09310 -4.11822  1.000 22.36135 ? 229 ASP   A OD2 1 
ATOM   1861 N  N   . GLY   A 1 230 ? -21.48624 13.03330 -3.99836  1.000 15.72127 ? 230 GLY   A N   1 
ATOM   1862 C  CA  . GLY   A 1 230 ? -20.38866 13.73020 -4.64188  1.000 18.23208 ? 230 GLY   A CA  1 
ATOM   1863 C  C   . GLY   A 1 230 ? -19.95268 14.96811 -3.88663  1.000 17.94244 ? 230 GLY   A C   1 
ATOM   1864 O  O   . GLY   A 1 230 ? -20.51712 15.33426 -2.85144  1.000 14.46776 ? 230 GLY   A O   1 
ATOM   1865 N  N   . ILE   A 1 231 ? -18.92312 15.60309 -4.43782  1.000 13.92707 ? 231 ILE   A N   1 
ATOM   1866 C  CA  . ILE   A 1 231 ? -18.34811 16.84461 -3.93225  1.000 14.50180 ? 231 ILE   A CA  1 
ATOM   1867 C  C   . ILE   A 1 231 ? -18.50235 17.92019 -5.00819  1.000 14.06553 ? 231 ILE   A C   1 
ATOM   1868 O  O   . ILE   A 1 231 ? -18.15384 17.67570 -6.17259  1.000 12.10556 ? 231 ILE   A O   1 
ATOM   1869 C  CB  . ILE   A 1 231 ? -16.85659 16.67280 -3.58808  1.000 14.69727 ? 231 ILE   A CB  1 
ATOM   1870 C  CG1 . ILE   A 1 231 ? -16.66219 15.59685 -2.52122  1.000 16.72656 ? 231 ILE   A CG1 1 
ATOM   1871 C  CG2 . ILE   A 1 231 ? -16.23344 18.03148 -3.18989  1.000 12.72284 ? 231 ILE   A CG2 1 
ATOM   1872 C  CD1 . ILE   A 1 231 ? -17.05508 16.06983 -1.12164  1.000 21.23075 ? 231 ILE   A CD1 1 
ATOM   1873 N  N   . GLY   A 1 232 ? -18.97808 19.09330 -4.62307  1.000 14.81192 ? 232 GLY   A N   1 
ATOM   1874 C  CA  . GLY   A 1 232 ? -19.00256 20.25029 -5.49889  1.000 12.32932 ? 232 GLY   A CA  1 
ATOM   1875 C  C   . GLY   A 1 232 ? -17.78164 21.11803 -5.25087  1.000 14.65744 ? 232 GLY   A C   1 
ATOM   1876 O  O   . GLY   A 1 232 ? -17.55681 21.57634 -4.13124  1.000 13.61847 ? 232 GLY   A O   1 
ATOM   1877 N  N   . HIS   A 1 233 ? -16.97554 21.30871 -6.29870  1.000 12.23620 ? 233 HIS   A N   1 
ATOM   1878 C  CA  . HIS   A 1 233 ? -15.81019 22.19519 -6.25045  1.000 14.70117 ? 233 HIS   A CA  1 
ATOM   1879 C  C   . HIS   A 1 233 ? -16.20465 23.53404 -6.86457  1.000 14.94844 ? 233 HIS   A C   1 
ATOM   1880 O  O   . HIS   A 1 233 ? -16.34240 23.64432 -8.09025  1.000 14.75875 ? 233 HIS   A O   1 
ATOM   1881 C  CB  . HIS   A 1 233 ? -14.62289 21.58642 -6.99212  1.000 13.89517 ? 233 HIS   A CB  1 
ATOM   1882 C  CG  . HIS   A 1 233 ? -14.31238 20.18041 -6.57847  1.000 16.07702 ? 233 HIS   A CG  1 
ATOM   1883 N  ND1 . HIS   A 1 233 ? -13.38230 19.87727 -5.60775  1.000 15.24155 ? 233 HIS   A ND1 1 
ATOM   1884 C  CD2 . HIS   A 1 233 ? -14.81764 18.99555 -6.99776  1.000 14.09079 ? 233 HIS   A CD2 1 
ATOM   1885 C  CE1 . HIS   A 1 233 ? -13.32796 18.56714 -5.44759  1.000 12.99475 ? 233 HIS   A CE1 1 
ATOM   1886 N  NE2 . HIS   A 1 233 ? -14.18280 18.00868 -6.28425  1.000 14.53799 ? 233 HIS   A NE2 1 
ATOM   1887 N  N   . GLN   A 1 234 ? -16.40556 24.54528 -6.01430  1.000 13.91653 ? 234 GLN   A N   1 
ATOM   1888 C  CA  . GLN   A 1 234 ? -16.77918 25.86053 -6.52153  1.000 13.78837 ? 234 GLN   A CA  1 
ATOM   1889 C  C   . GLN   A 1 234 ? -15.77895 26.36133 -7.55051  1.000 13.49527 ? 234 GLN   A C   1 
ATOM   1890 O  O   . GLN   A 1 234 ? -16.16690 26.96768 -8.55771  1.000 13.37193 ? 234 GLN   A O   1 
ATOM   1891 C  CB  . GLN   A 1 234 ? -16.90192 26.86442 -5.37501  1.000 11.53129 ? 234 GLN   A CB  1 
ATOM   1892 C  CG  . GLN   A 1 234 ? -18.14515 26.66381 -4.48890  1.000 11.58620 ? 234 GLN   A CG  1 
ATOM   1893 C  CD  . GLN   A 1 234 ? -18.23991 27.70329 -3.37718  1.000 16.86135 ? 234 GLN   A CD  1 
ATOM   1894 O  OE1 . GLN   A 1 234 ? -17.67365 28.78822 -3.49186  1.000 15.21196 ? 234 GLN   A OE1 1 
ATOM   1895 N  NE2 . GLN   A 1 234 ? -18.96092 27.37973 -2.30648  1.000 13.08711 ? 234 GLN   A NE2 1 
ATOM   1896 N  N   . SER   A 1 235 ? -14.48758 26.12794 -7.31500  1.000 10.56746 ? 235 SER   A N   1 
ATOM   1897 C  CA  . SER   A 1 235 ? -13.43683 26.52979 -8.25479  1.000 14.09804 ? 235 SER   A CA  1 
ATOM   1898 C  C   . SER   A 1 235 ? -13.47501 28.02639 -8.57728  1.000 13.35707 ? 235 SER   A C   1 
ATOM   1899 O  O   . SER   A 1 235 ? -13.46309 28.44022 -9.74058  1.000 11.57818 ? 235 SER   A O   1 
ATOM   1900 C  CB  . SER   A 1 235 ? -13.48536 25.68894 -9.53426  1.000 10.65413 ? 235 SER   A CB  1 
ATOM   1901 O  OG  . SER   A 1 235 ? -13.58742 24.31080 -9.19458  1.000 14.48646 ? 235 SER   A OG  1 
ATOM   1902 N  N   . HIS   A 1 236 ? -13.50829 28.84706 -7.53038  1.000 13.06218 ? 236 HIS   A N   1 
ATOM   1903 C  CA  . HIS   A 1 236 ? -13.24028 30.27655 -7.70890  1.000 13.79246 ? 236 HIS   A CA  1 
ATOM   1904 C  C   . HIS   A 1 236 ? -11.72573 30.45346 -7.69599  1.000 12.79053 ? 236 HIS   A C   1 
ATOM   1905 O  O   . HIS   A 1 236 ? -11.10315 30.59668 -6.64482  1.000 15.63497 ? 236 HIS   A O   1 
ATOM   1906 C  CB  . HIS   A 1 236 ? -13.93785 31.08922 -6.62504  1.000 14.39531 ? 236 HIS   A CB  1 
ATOM   1907 C  CG  . HIS   A 1 236 ? -15.42866 31.01720 -6.71738  1.000 14.29213 ? 236 HIS   A CG  1 
ATOM   1908 N  ND1 . HIS   A 1 236 ? -16.11792 31.44864 -7.83197  1.000 14.56906 ? 236 HIS   A ND1 1 
ATOM   1909 C  CD2 . HIS   A 1 236 ? -16.35509 30.50057 -5.87542  1.000 12.80116 ? 236 HIS   A CD2 1 
ATOM   1910 C  CE1 . HIS   A 1 236 ? -17.40901 31.21930 -7.66302  1.000 14.85954 ? 236 HIS   A CE1 1 
ATOM   1911 N  NE2 . HIS   A 1 236 ? -17.57982 30.64239 -6.48588  1.000 14.49398 ? 236 HIS   A NE2 1 
ATOM   1912 N  N   . ILE   A 1 237 ? -11.12222 30.42739 -8.88179  1.000 15.67625 ? 237 ILE   A N   1 
ATOM   1913 C  CA  . ILE   A 1 237 ? -9.68072  30.30458 -9.01492  1.000 15.39587 ? 237 ILE   A CA  1 
ATOM   1914 C  C   . ILE   A 1 237 ? -9.10835  31.53372 -9.72533  1.000 16.90596 ? 237 ILE   A C   1 
ATOM   1915 O  O   . ILE   A 1 237 ? -9.83218  32.39455 -10.24099 1.000 12.14711 ? 237 ILE   A O   1 
ATOM   1916 C  CB  . ILE   A 1 237 ? -9.28020  29.00953 -9.75176  1.000 14.45697 ? 237 ILE   A CB  1 
ATOM   1917 C  CG1 . ILE   A 1 237 ? -9.66879  29.08416 -11.23721 1.000 14.10276 ? 237 ILE   A CG1 1 
ATOM   1918 C  CG2 . ILE   A 1 237 ? -9.91451  27.78645 -9.08546  1.000 12.58564 ? 237 ILE   A CG2 1 
ATOM   1919 C  CD1 . ILE   A 1 237 ? -9.40683  27.76162 -11.99613 1.000 11.42899 ? 237 ILE   A CD1 1 
ATOM   1920 N  N   . GLN   A 1 238 ? -7.77731  31.58026 -9.74978  1.000 13.27693 ? 238 GLN   A N   1 
ATOM   1921 C  CA  . GLN   A 1 238 ? -6.97605  32.63942 -10.33358 1.000 13.38191 ? 238 GLN   A CA  1 
ATOM   1922 C  C   . GLN   A 1 238 ? -6.22677  32.07897 -11.53055 1.000 16.04832 ? 238 GLN   A C   1 
ATOM   1923 O  O   . GLN   A 1 238 ? -6.27185  30.87123 -11.80575 1.000 15.05786 ? 238 GLN   A O   1 
ATOM   1924 C  CB  . GLN   A 1 238 ? -6.02491  33.22111 -9.27849  1.000 14.39644 ? 238 GLN   A CB  1 
ATOM   1925 C  CG  . GLN   A 1 238 ? -6.77632  33.93495 -8.13621  1.000 16.54490 ? 238 GLN   A CG  1 
ATOM   1926 C  CD  . GLN   A 1 238 ? -5.99294  34.00877 -6.83137  1.000 18.32538 ? 238 GLN   A CD  1 
ATOM   1927 O  OE1 . GLN   A 1 238 ? -6.57305  33.92115 -5.74730  1.000 24.96350 ? 238 GLN   A OE1 1 
ATOM   1928 N  NE2 . GLN   A 1 238 ? -4.68773  34.18520 -6.92809  1.000 16.32201 ? 238 GLN   A NE2 1 
ATOM   1929 N  N   . ILE   A 1 239 ? -5.52136  32.96563 -12.24503 1.000 19.45234 ? 239 ILE   A N   1 
ATOM   1930 C  CA  . ILE   A 1 239 ? -4.75875  32.51413 -13.40619 1.000 16.84782 ? 239 ILE   A CA  1 
ATOM   1931 C  C   . ILE   A 1 239 ? -3.65022  31.55186 -12.98197 1.000 18.25521 ? 239 ILE   A C   1 
ATOM   1932 O  O   . ILE   A 1 239 ? -3.35707  30.58045 -13.68921 1.000 17.19931 ? 239 ILE   A O   1 
ATOM   1933 C  CB  . ILE   A 1 239 ? -4.21934  33.72950 -14.19459 1.000 20.40922 ? 239 ILE   A CB  1 
ATOM   1934 C  CG1 . ILE   A 1 239 ? -5.34468  34.37750 -15.01521 1.000 17.37245 ? 239 ILE   A CG1 1 
ATOM   1935 C  CG2 . ILE   A 1 239 ? -3.05644  33.32698 -15.11403 1.000 18.52336 ? 239 ILE   A CG2 1 
ATOM   1936 C  CD1 . ILE   A 1 239 ? -5.02149  35.79193 -15.54895 1.000 12.66305 ? 239 ILE   A CD1 1 
ATOM   1937 N  N   . GLY   A 1 240 ? -3.05017  31.76908 -11.81177 1.000 18.09060 ? 240 GLY   A N   1 
ATOM   1938 C  CA  . GLY   A 1 240 ? -1.90842  30.96432 -11.41032 1.000 24.15072 ? 240 GLY   A CA  1 
ATOM   1939 C  C   . GLY   A 1 240 ? -2.08700  30.10411 -10.16760 1.000 28.29347 ? 240 GLY   A C   1 
ATOM   1940 O  O   . GLY   A 1 240 ? -1.18490  29.34409 -9.80233  1.000 38.79627 ? 240 GLY   A O   1 
ATOM   1941 N  N   . TRP   A 1 241 ? -3.23166  30.21242 -9.49848  1.000 19.20716 ? 241 TRP   A N   1 
ATOM   1942 C  CA  . TRP   A 1 241 ? -3.47049  29.49599 -8.25488  1.000 20.58685 ? 241 TRP   A CA  1 
ATOM   1943 C  C   . TRP   A 1 241 ? -4.92753  29.06067 -8.25872  1.000 17.76253 ? 241 TRP   A C   1 
ATOM   1944 O  O   . TRP   A 1 241 ? -5.78872  29.82209 -8.72135  1.000 16.64856 ? 241 TRP   A O   1 
ATOM   1945 C  CB  . TRP   A 1 241 ? -3.19183  30.37662 -7.02369  1.000 19.30436 ? 241 TRP   A CB  1 
ATOM   1946 C  CG  . TRP   A 1 241 ? -3.64475  29.76934 -5.70860  1.000 25.03414 ? 241 TRP   A CG  1 
ATOM   1947 C  CD1 . TRP   A 1 241 ? -2.87090  29.08967 -4.81258  1.000 26.73208 ? 241 TRP   A CD1 1 
ATOM   1948 C  CD2 . TRP   A 1 241 ? -4.96895  29.80502 -5.14532  1.000 23.66443 ? 241 TRP   A CD2 1 
ATOM   1949 N  NE1 . TRP   A 1 241 ? -3.62727  28.69791 -3.73189  1.000 29.21993 ? 241 TRP   A NE1 1 
ATOM   1950 C  CE2 . TRP   A 1 241 ? -4.91810  29.12182 -3.91371  1.000 28.02565 ? 241 TRP   A CE2 1 
ATOM   1951 C  CE3 . TRP   A 1 241 ? -6.18941  30.35381 -5.56183  1.000 20.58752 ? 241 TRP   A CE3 1 
ATOM   1952 C  CZ2 . TRP   A 1 241 ? -6.04478  28.96873 -3.09232  1.000 28.06857 ? 241 TRP   A CZ2 1 
ATOM   1953 C  CZ3 . TRP   A 1 241 ? -7.31100  30.18993 -4.74962  1.000 24.23661 ? 241 TRP   A CZ3 1 
ATOM   1954 C  CH2 . TRP   A 1 241 ? -7.22641  29.50728 -3.53009  1.000 25.47526 ? 241 TRP   A CH2 1 
ATOM   1955 N  N   . PRO   A 1 242 ? -5.23800  27.84361 -7.77817  1.000 18.33074 ? 242 PRO   A N   1 
ATOM   1956 C  CA  . PRO   A 1 242 ? -4.26610  26.81241 -7.39562  1.000 18.04926 ? 242 PRO   A CA  1 
ATOM   1957 C  C   . PRO   A 1 242 ? -3.70911  26.08151 -8.61707  1.000 16.97480 ? 242 PRO   A C   1 
ATOM   1958 O  O   . PRO   A 1 242 ? -4.26997  26.19262 -9.70562  1.000 18.61837 ? 242 PRO   A O   1 
ATOM   1959 C  CB  . PRO   A 1 242 ? -5.08006  25.86888 -6.51378  1.000 20.41034 ? 242 PRO   A CB  1 
ATOM   1960 C  CG  . PRO   A 1 242 ? -6.48665  26.01926 -6.99687  1.000 22.90460 ? 242 PRO   A CG  1 
ATOM   1961 C  CD  . PRO   A 1 242 ? -6.62585  27.42959 -7.49734  1.000 18.33225 ? 242 PRO   A CD  1 
ATOM   1962 N  N   . SER   A 1 243 ? -2.60390  25.36506 -8.43397  1.000 19.36329 ? 243 SER   A N   1 
ATOM   1963 C  CA  . SER   A 1 243 ? -1.92764  24.70320 -9.53870  1.000 20.11900 ? 243 SER   A CA  1 
ATOM   1964 C  C   . SER   A 1 243 ? -2.78195  23.57773 -10.09388 1.000 15.89966 ? 243 SER   A C   1 
ATOM   1965 O  O   . SER   A 1 243 ? -3.58080  22.96961 -9.38437  1.000 16.68784 ? 243 SER   A O   1 
ATOM   1966 C  CB  . SER   A 1 243 ? -0.58638  24.13296 -9.07689  1.000 17.87382 ? 243 SER   A CB  1 
ATOM   1967 O  OG  . SER   A 1 243 ? -0.78419  22.95427 -8.30991  1.000 18.19679 ? 243 SER   A OG  1 
ATOM   1968 N  N   . GLU   A 1 244 ? -2.58521  23.28099 -11.37542 1.000 19.90840 ? 244 GLU   A N   1 
ATOM   1969 C  CA  . GLU   A 1 244 ? -3.28792  22.14666 -11.96828 1.000 22.00736 ? 244 GLU   A CA  1 
ATOM   1970 C  C   . GLU   A 1 244 ? -2.96800  20.84778 -11.23286 1.000 20.73406 ? 244 GLU   A C   1 
ATOM   1971 O  O   . GLU   A 1 244 ? -3.84769  19.99839 -11.05770 1.000 19.25419 ? 244 GLU   A O   1 
ATOM   1972 C  CB  . GLU   A 1 244 ? -2.94826  22.02991 -13.45708 1.000 18.91597 ? 244 GLU   A CB  1 
ATOM   1973 C  CG  . GLU   A 1 244 ? -3.67651  23.04234 -14.33613 1.000 18.37843 ? 244 GLU   A CG  1 
ATOM   1974 C  CD  . GLU   A 1 244 ? -2.78774  24.22413 -14.71145 1.000 23.08591 ? 244 GLU   A CD  1 
ATOM   1975 O  OE1 . GLU   A 1 244 ? -1.59857  24.00260 -15.03051 1.000 27.17837 ? 244 GLU   A OE1 1 
ATOM   1976 O  OE2 . GLU   A 1 244 ? -3.26583  25.37216 -14.68711 1.000 20.04106 ? 244 GLU   A OE2 1 
ATOM   1977 N  N   . ALA   A 1 245 ? -1.71814  20.68053 -10.77957 1.000 21.51929 ? 245 ALA   A N   1 
ATOM   1978 C  CA  . ALA   A 1 245 ? -1.34817  19.45278 -10.07872 1.000 19.90409 ? 245 ALA   A CA  1 
ATOM   1979 C  C   . ALA   A 1 245 ? -2.15892  19.28431 -8.79638  1.000 20.76177 ? 245 ALA   A C   1 
ATOM   1980 O  O   . ALA   A 1 245 ? -2.57876  18.16997 -8.45966  1.000 20.95183 ? 245 ALA   A O   1 
ATOM   1981 C  CB  . ALA   A 1 245 ? 0.15780   19.44029 -9.77845  1.000 20.81592 ? 245 ALA   A CB  1 
ATOM   1982 N  N   . GLU   A 1 246 ? -2.40914  20.38162 -8.07409  1.000 18.07296 ? 246 GLU   A N   1 
ATOM   1983 C  CA  . GLU   A 1 246 ? -3.21022  20.26692 -6.86217  1.000 19.43024 ? 246 GLU   A CA  1 
ATOM   1984 C  C   . GLU   A 1 246 ? -4.69210  20.07123 -7.17600  1.000 19.20732 ? 246 GLU   A C   1 
ATOM   1985 O  O   . GLU   A 1 246 ? -5.39187  19.37304 -6.43091  1.000 19.66573 ? 246 GLU   A O   1 
ATOM   1986 C  CB  . GLU   A 1 246 ? -2.99657  21.49382 -5.98224  1.000 23.84452 ? 246 GLU   A CB  1 
ATOM   1987 C  CG  . GLU   A 1 246 ? -1.60526  21.57793 -5.37877  1.000 24.36009 ? 246 GLU   A CG  1 
ATOM   1988 C  CD  . GLU   A 1 246 ? -1.32333  20.46880 -4.37891  1.000 29.22822 ? 246 GLU   A CD  1 
ATOM   1989 O  OE1 . GLU   A 1 246 ? -2.26452  20.01605 -3.70238  1.000 25.17942 ? 246 GLU   A OE1 1 
ATOM   1990 O  OE2 . GLU   A 1 246 ? -0.14828  20.04758 -4.27087  1.000 38.27546 ? 246 GLU   A OE2 1 
ATOM   1991 N  N   . ILE   A 1 247 ? -5.19168  20.66291 -8.26740  1.000 15.35383 ? 247 ILE   A N   1 
ATOM   1992 C  CA  . ILE   A 1 247 ? -6.55788  20.36368 -8.69101  1.000 18.32012 ? 247 ILE   A CA  1 
ATOM   1993 C  C   . ILE   A 1 247 ? -6.70329  18.87477 -8.98043  1.000 17.49659 ? 247 ILE   A C   1 
ATOM   1994 O  O   . ILE   A 1 247 ? -7.67107  18.22986 -8.55062  1.000 15.59002 ? 247 ILE   A O   1 
ATOM   1995 C  CB  . ILE   A 1 247 ? -6.95353  21.22035 -9.91058  1.000 15.25609 ? 247 ILE   A CB  1 
ATOM   1996 C  CG1 . ILE   A 1 247 ? -6.98539  22.69798 -9.52264  1.000 15.82724 ? 247 ILE   A CG1 1 
ATOM   1997 C  CG2 . ILE   A 1 247 ? -8.32879  20.75175 -10.48032 1.000 10.66316 ? 247 ILE   A CG2 1 
ATOM   1998 C  CD1 . ILE   A 1 247 ? -7.17414  23.65125 -10.68045 1.000 13.91518 ? 247 ILE   A CD1 1 
ATOM   1999 N  N   . GLU   A 1 248 ? -5.72863  18.30586 -9.69372  1.000 17.09105 ? 248 GLU   A N   1 
ATOM   2000 C  CA  . GLU   A 1 248 ? -5.77159  16.89298 -10.04863 1.000 16.86770 ? 248 GLU   A CA  1 
ATOM   2001 C  C   . GLU   A 1 248 ? -5.73018  16.00829 -8.80831  1.000 19.52920 ? 248 GLU   A C   1 
ATOM   2002 O  O   . GLU   A 1 248 ? -6.49227  15.04066 -8.69393  1.000 16.70060 ? 248 GLU   A O   1 
ATOM   2003 C  CB  . GLU   A 1 248 ? -4.60250  16.57199 -10.98365 1.000 15.28216 ? 248 GLU   A CB  1 
ATOM   2004 C  CG  . GLU   A 1 248 ? -4.49616  15.10568 -11.35400 1.000 21.95112 ? 248 GLU   A CG  1 
ATOM   2005 C  CD  . GLU   A 1 248 ? -3.56922  14.88681 -12.53661 1.000 24.26543 ? 248 GLU   A CD  1 
ATOM   2006 O  OE1 . GLU   A 1 248 ? -2.64390  15.70722 -12.72464 1.000 26.42432 ? 248 GLU   A OE1 1 
ATOM   2007 O  OE2 . GLU   A 1 248 ? -3.76991  13.90060 -13.27544 1.000 23.15954 ? 248 GLU   A OE2 1 
ATOM   2008 N  N   . LYS   A 1 249 ? -4.84083  16.32674 -7.86782  1.000 23.55480 ? 249 LYS   A N   1 
ATOM   2009 C  CA  . LYS   A 1 249 ? -4.74701  15.55032 -6.63616  1.000 21.61808 ? 249 LYS   A CA  1 
ATOM   2010 C  C   . LYS   A 1 249 ? -6.06326  15.60581 -5.86406  1.000 23.50378 ? 249 LYS   A C   1 
ATOM   2011 O  O   . LYS   A 1 249 ? -6.54891  14.58457 -5.35384  1.000 22.33592 ? 249 LYS   A O   1 
ATOM   2012 C  CB  . LYS   A 1 249 ? -3.56602  16.08869 -5.81703  1.000 19.24515 ? 249 LYS   A CB  1 
ATOM   2013 C  CG  . LYS   A 1 249 ? -3.32641  15.48487 -4.45552  1.000 25.02730 ? 249 LYS   A CG  1 
ATOM   2014 C  CD  . LYS   A 1 249 ? -2.02183  16.07241 -3.85084  1.000 26.16380 ? 249 LYS   A CD  1 
ATOM   2015 C  CE  . LYS   A 1 249 ? -1.75536  15.53950 -2.43415  1.000 35.48767 ? 249 LYS   A CE  1 
ATOM   2016 N  NZ  . LYS   A 1 249 ? -0.36767  15.85180 -1.93237  1.000 39.07956 ? 249 LYS   A NZ  1 
ATOM   2017 N  N   . THR   A 1 250 ? -6.67467  16.78860 -5.80689  1.000 19.72370 ? 250 THR   A N   1 
ATOM   2018 C  CA  . THR   A 1 250 ? -7.95712  16.94716 -5.13079  1.000 19.97652 ? 250 THR   A CA  1 
ATOM   2019 C  C   . THR   A 1 250 ? -9.03167  16.07136 -5.76259  1.000 21.00675 ? 250 THR   A C   1 
ATOM   2020 O  O   . THR   A 1 250 ? -9.76124  15.35871 -5.06085  1.000 20.47901 ? 250 THR   A O   1 
ATOM   2021 C  CB  . THR   A 1 250 ? -8.37262  18.41572 -5.17225  1.000 19.85161 ? 250 THR   A CB  1 
ATOM   2022 O  OG1 . THR   A 1 250 ? -7.30642  19.22210 -4.64412  1.000 18.16892 ? 250 THR   A OG1 1 
ATOM   2023 C  CG2 . THR   A 1 250 ? -9.65846  18.63442 -4.37682  1.000 18.38872 ? 250 THR   A CG2 1 
ATOM   2024 N  N   . ILE   A 1 251 ? -9.15056  16.12055 -7.09180  1.000 18.54973 ? 251 ILE   A N   1 
ATOM   2025 C  CA  . ILE   A 1 251 ? -10.21583 15.38520 -7.76996  1.000 19.74168 ? 251 ILE   A CA  1 
ATOM   2026 C  C   . ILE   A 1 251 ? -10.03803 13.88271 -7.56258  1.000 23.32843 ? 251 ILE   A C   1 
ATOM   2027 O  O   . ILE   A 1 251 ? -11.00131 13.15825 -7.26537  1.000 19.55228 ? 251 ILE   A O   1 
ATOM   2028 C  CB  . ILE   A 1 251 ? -10.25228 15.74806 -9.26732  1.000 22.75952 ? 251 ILE   A CB  1 
ATOM   2029 C  CG1 . ILE   A 1 251 ? -10.55902 17.23284 -9.46686  1.000 18.63364 ? 251 ILE   A CG1 1 
ATOM   2030 C  CG2 . ILE   A 1 251 ? -11.26905 14.89451 -10.00644 1.000 20.72824 ? 251 ILE   A CG2 1 
ATOM   2031 C  CD1 . ILE   A 1 251 ? -11.99268 17.56763 -9.27080  1.000 20.90483 ? 251 ILE   A CD1 1 
ATOM   2032 N  N   . ASN   A 1 252 ? -8.79882  13.39814 -7.71505  1.000 19.47951 ? 252 ASN   A N   1 
ATOM   2033 C  CA  . ASN   A 1 252 ? -8.52353  11.97101 -7.56688  1.000 23.85379 ? 252 ASN   A CA  1 
ATOM   2034 C  C   . ASN   A 1 252 ? -8.80920  11.50125 -6.15434  1.000 20.47666 ? 252 ASN   A C   1 
ATOM   2035 O  O   . ASN   A 1 252 ? -9.36745  10.41983 -5.94721  1.000 24.54016 ? 252 ASN   A O   1 
ATOM   2036 C  CB  . ASN   A 1 252 ? -7.06513  11.67796 -7.91150  1.000 20.96603 ? 252 ASN   A CB  1 
ATOM   2037 C  CG  . ASN   A 1 252 ? -6.80743  11.72314 -9.37885  1.000 20.42837 ? 252 ASN   A CG  1 
ATOM   2038 O  OD1 . ASN   A 1 252 ? -7.71891  11.54322 -10.17942 1.000 20.75897 ? 252 ASN   A OD1 1 
ATOM   2039 N  ND2 . ASN   A 1 252 ? -5.56391  11.97002 -9.75325  1.000 19.94108 ? 252 ASN   A ND2 1 
ATOM   2040 N  N   . MET   A 1 253 ? -8.40162  12.29832 -5.17451  1.000 22.05982 ? 253 MET   A N   1 
ATOM   2041 C  CA  . MET   A 1 253 ? -8.62415  11.97919 -3.77243  1.000 20.57045 ? 253 MET   A CA  1 
ATOM   2042 C  C   . MET   A 1 253 ? -10.10029 11.71195 -3.49343  1.000 25.43285 ? 253 MET   A C   1 
ATOM   2043 O  O   . MET   A 1 253 ? -10.46038 10.71929 -2.84952  1.000 24.51962 ? 253 MET   A O   1 
ATOM   2044 C  CB  . MET   A 1 253 ? -8.10279  13.14427 -2.93512  1.000 25.02111 ? 253 MET   A CB  1 
ATOM   2045 C  CG  . MET   A 1 253 ? -7.97004  12.90994 -1.46461  1.000 28.46712 ? 253 MET   A CG  1 
ATOM   2046 S  SD  . MET   A 1 253 ? -7.50590  14.48242 -0.71005  1.000 34.12473 ? 253 MET   A SD  1 
ATOM   2047 C  CE  . MET   A 1 253 ? -5.92669  14.77854 -1.47704  1.000 18.45243 ? 253 MET   A CE  1 
ATOM   2048 N  N   . PHE   A 1 254 ? -10.97956 12.58254 -3.97835  1.000 23.74128 ? 254 PHE   A N   1 
ATOM   2049 C  CA  . PHE   A 1 254 ? -12.38988 12.35454 -3.69003  1.000 22.97312 ? 254 PHE   A CA  1 
ATOM   2050 C  C   . PHE   A 1 254 ? -12.97324 11.24681 -4.54897  1.000 20.12849 ? 254 PHE   A C   1 
ATOM   2051 O  O   . PHE   A 1 254 ? -13.85330 10.51815 -4.08210  1.000 23.80670 ? 254 PHE   A O   1 
ATOM   2052 C  CB  . PHE   A 1 254 ? -13.17040 13.65732 -3.83581  1.000 17.57219 ? 254 PHE   A CB  1 
ATOM   2053 C  CG  . PHE   A 1 254 ? -12.89974 14.61333 -2.72073  1.000 20.78762 ? 254 PHE   A CG  1 
ATOM   2054 C  CD1 . PHE   A 1 254 ? -13.37278 14.34776 -1.44484  1.000 19.09486 ? 254 PHE   A CD1 1 
ATOM   2055 C  CD2 . PHE   A 1 254 ? -12.12004 15.73980 -2.92502  1.000 19.40553 ? 254 PHE   A CD2 1 
ATOM   2056 C  CE1 . PHE   A 1 254 ? -13.11353 15.20509 -0.39763  1.000 17.44118 ? 254 PHE   A CE1 1 
ATOM   2057 C  CE2 . PHE   A 1 254 ? -11.85034 16.60582 -1.88136  1.000 22.94705 ? 254 PHE   A CE2 1 
ATOM   2058 C  CZ  . PHE   A 1 254 ? -12.35408 16.33710 -0.60867  1.000 19.43649 ? 254 PHE   A CZ  1 
ATOM   2059 N  N   . ALA   A 1 255 ? -12.47445 11.06945 -5.77447  1.000 18.36603 ? 255 ALA   A N   1 
ATOM   2060 C  CA  . ALA   A 1 255 ? -12.93786 9.94964  -6.58923  1.000 23.78743 ? 255 ALA   A CA  1 
ATOM   2061 C  C   . ALA   A 1 255 ? -12.60344 8.61315  -5.93606  1.000 26.73323 ? 255 ALA   A C   1 
ATOM   2062 O  O   . ALA   A 1 255 ? -13.36055 7.64650  -6.07809  1.000 22.73593 ? 255 ALA   A O   1 
ATOM   2063 C  CB  . ALA   A 1 255 ? -12.32492 10.01614 -7.99083  1.000 22.29002 ? 255 ALA   A CB  1 
ATOM   2064 N  N   . ALA   A 1 256 ? -11.48088 8.54235  -5.21258  1.000 22.51111 ? 256 ALA   A N   1 
ATOM   2065 C  CA  . ALA   A 1 256 ? -11.08511 7.29997  -4.55996  1.000 22.45834 ? 256 ALA   A CA  1 
ATOM   2066 C  C   . ALA   A 1 256 ? -12.06575 6.86449  -3.47836  1.000 22.11966 ? 256 ALA   A C   1 
ATOM   2067 O  O   . ALA   A 1 256 ? -12.11759 5.67271  -3.16644  1.000 25.13924 ? 256 ALA   A O   1 
ATOM   2068 C  CB  . ALA   A 1 256 ? -9.68046  7.43118  -3.96770  1.000 22.65179 ? 256 ALA   A CB  1 
ATOM   2069 N  N   . LEU   A 1 257 ? -12.84325 7.78590  -2.90854  1.000 21.74928 ? 257 LEU   A N   1 
ATOM   2070 C  CA  . LEU   A 1 257 ? -13.91815 7.43805  -1.98152  1.000 19.60141 ? 257 LEU   A CA  1 
ATOM   2071 C  C   . LEU   A 1 257 ? -15.20535 7.05175  -2.66785  1.000 22.45237 ? 257 LEU   A C   1 
ATOM   2072 O  O   . LEU   A 1 257 ? -16.20817 6.86841  -1.97177  1.000 24.00975 ? 257 LEU   A O   1 
ATOM   2073 C  CB  . LEU   A 1 257 ? -14.22408 8.59584  -1.03016  1.000 21.20428 ? 257 LEU   A CB  1 
ATOM   2074 C  CG  . LEU   A 1 257 ? -13.02949 9.21848  -0.34978  1.000 28.70976 ? 257 LEU   A CG  1 
ATOM   2075 C  CD1 . LEU   A 1 257 ? -13.48473 10.24825 0.66585   1.000 24.42295 ? 257 LEU   A CD1 1 
ATOM   2076 C  CD2 . LEU   A 1 257 ? -12.22623 8.11448  0.30643   1.000 30.52471 ? 257 LEU   A CD2 1 
ATOM   2077 N  N   . GLY   A 1 258 ? -15.21783 6.93779  -3.99442  1.000 23.91785 ? 258 GLY   A N   1 
ATOM   2078 C  CA  . GLY   A 1 258 ? -16.45274 6.65013  -4.69270  1.000 21.80948 ? 258 GLY   A CA  1 
ATOM   2079 C  C   . GLY   A 1 258 ? -17.38706 7.83109  -4.86636  1.000 23.19177 ? 258 GLY   A C   1 
ATOM   2080 O  O   . GLY   A 1 258 ? -18.58374 7.62978  -5.07430  1.000 25.44515 ? 258 GLY   A O   1 
ATOM   2081 N  N   . LEU   A 1 259 ? -16.88580 9.06010  -4.80758  1.000 19.56320 ? 259 LEU   A N   1 
ATOM   2082 C  CA  . LEU   A 1 259 ? -17.72402 10.23482 -4.99472  1.000 18.52138 ? 259 LEU   A CA  1 
ATOM   2083 C  C   . LEU   A 1 259 ? -17.59879 10.78051 -6.41141  1.000 18.30983 ? 259 LEU   A C   1 
ATOM   2084 O  O   . LEU   A 1 259 ? -16.51545 10.77653 -7.00045  1.000 18.44663 ? 259 LEU   A O   1 
ATOM   2085 C  CB  . LEU   A 1 259 ? -17.35835 11.33273 -3.99752  1.000 20.27895 ? 259 LEU   A CB  1 
ATOM   2086 C  CG  . LEU   A 1 259 ? -17.46915 10.95638 -2.51954  1.000 21.14827 ? 259 LEU   A CG  1 
ATOM   2087 C  CD1 . LEU   A 1 259 ? -16.36966 11.66837 -1.72575  1.000 21.52761 ? 259 LEU   A CD1 1 
ATOM   2088 C  CD2 . LEU   A 1 259 ? -18.84434 11.28137 -1.97047  1.000 19.48973 ? 259 LEU   A CD2 1 
ATOM   2089 N  N   . ASP   A 1 260 ? -18.71932 11.24300 -6.95369  1.000 18.01039 ? 260 ASP   A N   1 
ATOM   2090 C  CA  . ASP   A 1 260 ? -18.70308 12.08980 -8.14142  1.000 16.51082 ? 260 ASP   A CA  1 
ATOM   2091 C  C   . ASP   A 1 260 ? -18.06829 13.44250 -7.80455  1.000 14.72818 ? 260 ASP   A C   1 
ATOM   2092 O  O   . ASP   A 1 260 ? -18.05577 13.87021 -6.64931  1.000 17.08014 ? 260 ASP   A O   1 
ATOM   2093 C  CB  . ASP   A 1 260 ? -20.13478 12.26957 -8.66270  1.000 14.62306 ? 260 ASP   A CB  1 
ATOM   2094 C  CG  . ASP   A 1 260 ? -20.20489 13.02587 -9.98397  1.000 19.24581 ? 260 ASP   A CG  1 
ATOM   2095 O  OD1 . ASP   A 1 260 ? -19.29997 12.85337 -10.82918 1.000 13.34822 ? 260 ASP   A OD1 1 
ATOM   2096 O  OD2 . ASP   A 1 260 ? -21.18363 13.79560 -10.16683 1.000 14.26550 ? 260 ASP   A OD2 1 
ATOM   2097 N  N   . ASN   A 1 261 ? -17.51275 14.10585 -8.82009  1.000 15.92243 ? 261 ASN   A N   1 
ATOM   2098 C  CA  . ASN   A 1 261 ? -16.99432 15.47050 -8.70058  1.000 15.13307 ? 261 ASN   A CA  1 
ATOM   2099 C  C   . ASN   A 1 261 ? -17.72836 16.37991 -9.68137  1.000 15.29665 ? 261 ASN   A C   1 
ATOM   2100 O  O   . ASN   A 1 261 ? -17.87826 16.03191 -10.85639 1.000 15.98554 ? 261 ASN   A O   1 
ATOM   2101 C  CB  . ASN   A 1 261 ? -15.48548 15.52712 -8.98912  1.000 16.71379 ? 261 ASN   A CB  1 
ATOM   2102 C  CG  . ASN   A 1 261 ? -14.66169 14.77727 -7.95592  1.000 18.28490 ? 261 ASN   A CG  1 
ATOM   2103 O  OD1 . ASN   A 1 261 ? -14.31553 15.32566 -6.90100  1.000 15.04601 ? 261 ASN   A OD1 1 
ATOM   2104 N  ND2 . ASN   A 1 261 ? -14.33514 13.51769 -8.25688  1.000 15.27121 ? 261 ASN   A ND2 1 
ATOM   2105 N  N   . GLN   A 1 262 ? -18.17830 17.54430 -9.21049  1.000 15.51445 ? 262 GLN   A N   1 
ATOM   2106 C  CA  . GLN   A 1 262 ? -18.72981 18.55286 -10.10523 1.000 14.75662 ? 262 GLN   A CA  1 
ATOM   2107 C  C   . GLN   A 1 262 ? -18.00479 19.86539 -9.86512  1.000 12.80061 ? 262 GLN   A C   1 
ATOM   2108 O  O   . GLN   A 1 262 ? -17.72824 20.22644 -8.72003  1.000 12.71433 ? 262 GLN   A O   1 
ATOM   2109 C  CB  . GLN   A 1 262 ? -20.25386 18.71194 -9.91748  1.000 13.39923 ? 262 GLN   A CB  1 
ATOM   2110 C  CG  . GLN   A 1 262 ? -21.02365 17.43462 -10.32907 1.000 12.90336 ? 262 GLN   A CG  1 
ATOM   2111 C  CD  . GLN   A 1 262 ? -22.53200 17.61117 -10.43897 1.000 14.10311 ? 262 GLN   A CD  1 
ATOM   2112 O  OE1 . GLN   A 1 262 ? -23.15813 18.29987 -9.63367  1.000 15.19538 ? 262 GLN   A OE1 1 
ATOM   2113 N  NE2 . GLN   A 1 262 ? -23.12806 16.97076 -11.45091 1.000 15.02304 ? 262 GLN   A NE2 1 
ATOM   2114 N  N   . ILE   A 1 263 ? -17.64084 20.53061 -10.95507 1.000 10.64977 ? 263 ILE   A N   1 
ATOM   2115 C  CA  . ILE   A 1 263 ? -17.11211 21.88756 -10.92864 1.000 13.26328 ? 263 ILE   A CA  1 
ATOM   2116 C  C   . ILE   A 1 263 ? -18.32545 22.80627 -10.95969 1.000 11.32289 ? 263 ILE   A C   1 
ATOM   2117 O  O   . ILE   A 1 263 ? -19.01712 22.87862 -11.97690 1.000 12.91985 ? 263 ILE   A O   1 
ATOM   2118 C  CB  . ILE   A 1 263 ? -16.18859 22.14835 -12.12743 1.000 9.67815  ? 263 ILE   A CB  1 
ATOM   2119 C  CG1 . ILE   A 1 263 ? -15.18617 21.00368 -12.29609 1.000 14.44843 ? 263 ILE   A CG1 1 
ATOM   2120 C  CG2 . ILE   A 1 263 ? -15.50679 23.50624 -12.01511 1.000 12.01637 ? 263 ILE   A CG2 1 
ATOM   2121 C  CD1 . ILE   A 1 263 ? -14.31557 20.74620 -11.07533 1.000 17.29177 ? 263 ILE   A CD1 1 
ATOM   2122 N  N   . THR   A 1 264 ? -18.60680 23.50068 -9.85179  1.000 14.05816 ? 264 THR   A N   1 
ATOM   2123 C  CA  . THR   A 1 264 ? -19.93529 24.09094 -9.69228  1.000 14.80313 ? 264 THR   A CA  1 
ATOM   2124 C  C   . THR   A 1 264 ? -20.00568 25.59896 -9.86474  1.000 13.78110 ? 264 THR   A C   1 
ATOM   2125 O  O   . THR   A 1 264 ? -21.10337 26.11116 -10.09993 1.000 14.02894 ? 264 THR   A O   1 
ATOM   2126 C  CB  . THR   A 1 264 ? -20.52104 23.75577 -8.31459  1.000 13.28568 ? 264 THR   A CB  1 
ATOM   2127 O  OG1 . THR   A 1 264 ? -19.62396 24.22412 -7.29923  1.000 15.50529 ? 264 THR   A OG1 1 
ATOM   2128 C  CG2 . THR   A 1 264 ? -20.73368 22.24278 -8.18272  1.000 13.48856 ? 264 THR   A CG2 1 
ATOM   2129 N  N   . GLY   A 1 265 ? -18.89819 26.32545 -9.72993  1.000 13.85235 ? 265 GLY   A N   1 
ATOM   2130 C  CA  . GLY   A 1 265 ? -18.96317 27.77460 -9.85738  1.000 13.27577 ? 265 GLY   A CA  1 
ATOM   2131 C  C   . GLY   A 1 265 ? -17.72216 28.36176 -10.50806 1.000 13.48954 ? 265 GLY   A C   1 
ATOM   2132 O  O   . GLY   A 1 265 ? -17.19425 29.38418 -10.06290 1.000 11.86334 ? 265 GLY   A O   1 
ATOM   2133 N  N   . LEU   A 1 266 ? -17.23600 27.71865 -11.55941 1.000 11.50735 ? 266 LEU   A N   1 
ATOM   2134 C  CA  . LEU   A 1 266 ? -15.95150 28.10868 -12.12809 1.000 11.34958 ? 266 LEU   A CA  1 
ATOM   2135 C  C   . LEU   A 1 266 ? -15.96242 29.56760 -12.57968 1.000 13.80546 ? 266 LEU   A C   1 
ATOM   2136 O  O   . LEU   A 1 266 ? -16.87315 30.01190 -13.29303 1.000 10.41065 ? 266 LEU   A O   1 
ATOM   2137 C  CB  . LEU   A 1 266 ? -15.61034 27.19887 -13.30966 1.000 11.96540 ? 266 LEU   A CB  1 
ATOM   2138 C  CG  . LEU   A 1 266 ? -14.35077 27.50900 -14.11806 1.000 11.71929 ? 266 LEU   A CG  1 
ATOM   2139 C  CD1 . LEU   A 1 266 ? -13.12970 27.43729 -13.22717 1.000 8.37992  ? 266 LEU   A CD1 1 
ATOM   2140 C  CD2 . LEU   A 1 266 ? -14.22970 26.51856 -15.28858 1.000 9.41707  ? 266 LEU   A CD2 1 
ATOM   2141 N  N   . ASP   A 1 267 ? -14.95531 30.31570 -12.13314 1.000 9.89780  ? 267 ASP   A N   1 
ATOM   2142 C  CA  . ASP   A 1 267 ? -14.55819 31.56125 -12.76817 1.000 10.61131 ? 267 ASP   A CA  1 
ATOM   2143 C  C   . ASP   A 1 267 ? -13.04294 31.67266 -12.63097 1.000 14.08217 ? 267 ASP   A C   1 
ATOM   2144 O  O   . ASP   A 1 267 ? -12.45752 31.15097 -11.67896 1.000 10.81829 ? 267 ASP   A O   1 
ATOM   2145 C  CB  . ASP   A 1 267 ? -15.31527 32.79610 -12.18839 1.000 10.70686 ? 267 ASP   A CB  1 
ATOM   2146 C  CG  . ASP   A 1 267 ? -15.58415 32.70226 -10.67163 1.000 15.41267 ? 267 ASP   A CG  1 
ATOM   2147 O  OD1 . ASP   A 1 267 ? -14.76357 32.10984 -9.93484  1.000 13.01462 ? 267 ASP   A OD1 1 
ATOM   2148 O  OD2 . ASP   A 1 267 ? -16.62593 33.23660 -10.22847 1.000 14.01484 ? 267 ASP   A OD2 1 
ATOM   2149 N  N   . VAL   A 1 268 ? -12.39740 32.28950 -13.61974 1.000 12.91533 ? 268 VAL   A N   1 
ATOM   2150 C  CA  . VAL   A 1 268 ? -10.94345 32.45251 -13.60825 1.000 12.47644 ? 268 VAL   A CA  1 
ATOM   2151 C  C   . VAL   A 1 268 ? -10.68360 33.95119 -13.51479 1.000 12.86701 ? 268 VAL   A C   1 
ATOM   2152 O  O   . VAL   A 1 268 ? -10.65400 34.66221 -14.52114 1.000 11.17095 ? 268 VAL   A O   1 
ATOM   2153 C  CB  . VAL   A 1 268 ? -10.25464 31.83729 -14.82881 1.000 15.98800 ? 268 VAL   A CB  1 
ATOM   2154 C  CG1 . VAL   A 1 268 ? -8.70737  32.02155 -14.69886 1.000 12.97715 ? 268 VAL   A CG1 1 
ATOM   2155 C  CG2 . VAL   A 1 268 ? -10.63687 30.36567 -14.98834 1.000 10.70672 ? 268 VAL   A CG2 1 
ATOM   2156 N  N   . SER   A 1 269 ? -10.49829 34.43762 -12.29274 1.000 11.30197 ? 269 SER   A N   1 
ATOM   2157 C  CA  . SER   A 1 269 ? -10.29749 35.85988 -12.06663 1.000 13.56065 ? 269 SER   A CA  1 
ATOM   2158 C  C   . SER   A 1 269 ? -9.03594  36.35980 -12.76653 1.000 16.31826 ? 269 SER   A C   1 
ATOM   2159 O  O   . SER   A 1 269 ? -8.03934  35.63913 -12.91137 1.000 11.02480 ? 269 SER   A O   1 
ATOM   2160 C  CB  . SER   A 1 269 ? -10.20141 36.14778 -10.57144 1.000 13.67227 ? 269 SER   A CB  1 
ATOM   2161 O  OG  . SER   A 1 269 ? -10.10032 37.54828 -10.33500 1.000 18.19421 ? 269 SER   A OG  1 
ATOM   2162 N  N   . MET   A 1 270 ? -9.08410  37.62022 -13.19705 1.000 16.52090 ? 270 MET   A N   1 
ATOM   2163 C  CA  . MET   A 1 270 ? -7.89312  38.27486 -13.71599 1.000 10.29079 ? 270 MET   A CA  1 
ATOM   2164 C  C   . MET   A 1 270 ? -6.92348  38.66522 -12.61719 1.000 16.64335 ? 270 MET   A C   1 
ATOM   2165 O  O   . MET   A 1 270 ? -5.78340  39.01553 -12.93111 1.000 14.42310 ? 270 MET   A O   1 
ATOM   2166 C  CB  . MET   A 1 270 ? -8.26241  39.52357 -14.51002 1.000 14.87729 ? 270 MET   A CB  1 
ATOM   2167 C  CG  . MET   A 1 270 ? -8.91650  39.26376 -15.85998 1.000 13.91143 ? 270 MET   A CG  1 
ATOM   2168 S  SD  . MET   A 1 270 ? -7.87919  38.24487 -16.95323 1.000 15.01073 ? 270 MET   A SD  1 
ATOM   2169 C  CE  . MET   A 1 270 ? -8.75924  38.47331 -18.50679 1.000 11.40447 ? 270 MET   A CE  1 
ATOM   2170 N  N   . TYR   A 1 271 ? -7.32997  38.60177 -11.34831 1.000 14.80175 ? 271 TYR   A N   1 
ATOM   2171 C  CA  . TYR   A 1 271 ? -6.57052  39.20974 -10.25906 1.000 15.41837 ? 271 TYR   A CA  1 
ATOM   2172 C  C   . TYR   A 1 271 ? -6.12661  38.16346 -9.24007  1.000 17.36999 ? 271 TYR   A C   1 
ATOM   2173 O  O   . TYR   A 1 271 ? -6.39883  36.96066 -9.36859  1.000 18.30336 ? 271 TYR   A O   1 
ATOM   2174 C  CB  . TYR   A 1 271 ? -7.39286  40.31533 -9.59059  1.000 15.48162 ? 271 TYR   A CB  1 
ATOM   2175 C  CG  . TYR   A 1 271 ? -7.97747  41.24039 -10.60455 1.000 15.09953 ? 271 TYR   A CG  1 
ATOM   2176 C  CD1 . TYR   A 1 271 ? -7.15360  41.95434 -11.45742 1.000 17.20766 ? 271 TYR   A CD1 1 
ATOM   2177 C  CD2 . TYR   A 1 271 ? -9.34592  41.38115 -10.74601 1.000 14.72589 ? 271 TYR   A CD2 1 
ATOM   2178 C  CE1 . TYR   A 1 271 ? -7.66869  42.80003 -12.41573 1.000 15.60553 ? 271 TYR   A CE1 1 
ATOM   2179 C  CE2 . TYR   A 1 271 ? -9.87569  42.23097 -11.71197 1.000 15.66045 ? 271 TYR   A CE2 1 
ATOM   2180 C  CZ  . TYR   A 1 271 ? -9.02665  42.93431 -12.54744 1.000 17.58086 ? 271 TYR   A CZ  1 
ATOM   2181 O  OH  . TYR   A 1 271 ? -9.52457  43.79799 -13.50553 1.000 13.94772 ? 271 TYR   A OH  1 
ATOM   2182 N  N   . GLY   A 1 272 ? -5.40705  38.63711 -8.23351  1.000 15.61695 ? 272 GLY   A N   1 
ATOM   2183 C  CA  . GLY   A 1 272 ? -4.94951  37.82438 -7.12958  1.000 16.75765 ? 272 GLY   A CA  1 
ATOM   2184 C  C   . GLY   A 1 272 ? -5.89021  37.91208 -5.94920  1.000 20.84714 ? 272 GLY   A C   1 
ATOM   2185 O  O   . GLY   A 1 272 ? -7.10685  38.04125 -6.11017  1.000 21.87077 ? 272 GLY   A O   1 
ATOM   2186 N  N   . TRP   A 1 273 ? -5.32097  37.86577 -4.74692  1.000 21.90602 ? 273 TRP   A N   1 
ATOM   2187 C  CA  . TRP   A 1 273 ? -6.12293  37.92566 -3.53036  1.000 20.61400 ? 273 TRP   A CA  1 
ATOM   2188 C  C   . TRP   A 1 273 ? -5.31748  38.56702 -2.40660  1.000 23.84226 ? 273 TRP   A C   1 
ATOM   2189 O  O   . TRP   A 1 273 ? -4.22154  38.08964 -2.08953  1.000 26.28727 ? 273 TRP   A O   1 
ATOM   2190 C  CB  . TRP   A 1 273 ? -6.59303  36.53590 -3.10675  1.000 19.21099 ? 273 TRP   A CB  1 
ATOM   2191 C  CG  . TRP   A 1 273 ? -7.49226  36.61551 -1.93013  1.000 22.56405 ? 273 TRP   A CG  1 
ATOM   2192 C  CD1 . TRP   A 1 273 ? -7.14699  36.45847 -0.62118  1.000 20.65447 ? 273 TRP   A CD1 1 
ATOM   2193 C  CD2 . TRP   A 1 273 ? -8.89736  36.93050 -1.94413  1.000 24.65353 ? 273 TRP   A CD2 1 
ATOM   2194 N  NE1 . TRP   A 1 273 ? -8.25603  36.63426 0.18101   1.000 28.40309 ? 273 TRP   A NE1 1 
ATOM   2195 C  CE2 . TRP   A 1 273 ? -9.34125  36.92174 -0.60732  1.000 22.41620 ? 273 TRP   A CE2 1 
ATOM   2196 C  CE3 . TRP   A 1 273 ? -9.82387  37.20256 -2.96132  1.000 23.53787 ? 273 TRP   A CE3 1 
ATOM   2197 C  CZ2 . TRP   A 1 273 ? -10.66788 37.17893 -0.25896  1.000 25.34988 ? 273 TRP   A CZ2 1 
ATOM   2198 C  CZ3 . TRP   A 1 273 ? -11.15317 37.45735 -2.60844  1.000 21.53036 ? 273 TRP   A CZ3 1 
ATOM   2199 C  CH2 . TRP   A 1 273 ? -11.55622 37.44618 -1.27590  1.000 21.68822 ? 273 TRP   A CH2 1 
ATOM   2200 N  N   . PRO   A 1 274 ? -5.79473  39.67406 -1.80519  1.000 23.17739 ? 274 PRO   A N   1 
ATOM   2201 C  CA  . PRO   A 1 274 ? -7.00161  40.41034 -2.20357  1.000 18.35595 ? 274 PRO   A CA  1 
ATOM   2202 C  C   . PRO   A 1 274 ? -6.83120  41.08237 -3.56826  1.000 18.69911 ? 274 PRO   A C   1 
ATOM   2203 O  O   . PRO   A 1 274 ? -5.73362  41.53351 -3.88691  1.000 18.18837 ? 274 PRO   A O   1 
ATOM   2204 C  CB  . PRO   A 1 274 ? -7.16357  41.46458 -1.09047  1.000 20.75873 ? 274 PRO   A CB  1 
ATOM   2205 C  CG  . PRO   A 1 274 ? -6.21854  41.06018 0.00018   1.000 25.85431 ? 274 PRO   A CG  1 
ATOM   2206 C  CD  . PRO   A 1 274 ? -5.10808  40.32775 -0.67413  1.000 20.88692 ? 274 PRO   A CD  1 
ATOM   2207 N  N   . PRO   A 1 275 ? -7.89717  41.13883 -4.36490  1.000 18.57038 ? 275 PRO   A N   1 
ATOM   2208 C  CA  . PRO   A 1 275 ? -7.75335  41.63546 -5.73815  1.000 17.31026 ? 275 PRO   A CA  1 
ATOM   2209 C  C   . PRO   A 1 275 ? -7.45351  43.13107 -5.77998  1.000 19.32080 ? 275 PRO   A C   1 
ATOM   2210 O  O   . PRO   A 1 275 ? -8.00274  43.93080 -5.00948  1.000 15.07344 ? 275 PRO   A O   1 
ATOM   2211 C  CB  . PRO   A 1 275 ? -9.11573  41.32736 -6.37944  1.000 17.66477 ? 275 PRO   A CB  1 
ATOM   2212 C  CG  . PRO   A 1 275 ? -9.86389  40.49170 -5.39921  1.000 18.39670 ? 275 PRO   A CG  1 
ATOM   2213 C  CD  . PRO   A 1 275 ? -9.29268  40.79387 -4.05139  1.000 17.44740 ? 275 PRO   A CD  1 
ATOM   2214 N  N   . ARG   A 1 276 ? -6.58378  43.50307 -6.71007  1.000 17.20867 ? 276 ARG   A N   1 
ATOM   2215 C  CA  . ARG   A 1 276 ? -6.36454  44.89564 -7.08905  1.000 17.23432 ? 276 ARG   A CA  1 
ATOM   2216 C  C   . ARG   A 1 276 ? -6.83583  45.02059 -8.53632  1.000 16.71628 ? 276 ARG   A C   1 
ATOM   2217 O  O   . ARG   A 1 276 ? -6.08556  44.74702 -9.47619  1.000 15.42798 ? 276 ARG   A O   1 
ATOM   2218 C  CB  . ARG   A 1 276 ? -4.91299  45.28695 -6.93200  1.000 16.80997 ? 276 ARG   A CB  1 
ATOM   2219 C  CG  . ARG   A 1 276 ? -4.38612  45.05138 -5.52569  1.000 18.12260 ? 276 ARG   A CG  1 
ATOM   2220 C  CD  . ARG   A 1 276 ? -3.15168  45.90070 -5.23179  1.000 21.97260 ? 276 ARG   A CD  1 
ATOM   2221 N  NE  . ARG   A 1 276 ? -2.84649  45.91874 -3.80071  1.000 21.38023 ? 276 ARG   A NE  1 
ATOM   2222 C  CZ  . ARG   A 1 276 ? -1.87065  46.63719 -3.24913  1.000 25.69107 ? 276 ARG   A CZ  1 
ATOM   2223 N  NH1 . ARG   A 1 276 ? -1.08538  47.39999 -4.00109  1.000 23.32174 ? 276 ARG   A NH1 1 
ATOM   2224 N  NH2 . ARG   A 1 276 ? -1.67735  46.58612 -1.94155  1.000 21.68619 ? 276 ARG   A NH2 1 
ATOM   2225 N  N   . ALA   A 1 277 ? -8.07387  45.46280 -8.70808  1.000 13.64646 ? 277 ALA   A N   1 
ATOM   2226 C  CA  . ALA   A 1 277 ? -8.74158  45.40230 -9.99887  1.000 14.33695 ? 277 ALA   A CA  1 
ATOM   2227 C  C   . ALA   A 1 277 ? -8.52095  46.66221 -10.82076 1.000 19.37697 ? 277 ALA   A C   1 
ATOM   2228 O  O   . ALA   A 1 277 ? -8.31497  47.75529 -10.28376 1.000 19.34548 ? 277 ALA   A O   1 
ATOM   2229 C  CB  . ALA   A 1 277 ? -10.24054 45.19535 -9.81138  1.000 11.24704 ? 277 ALA   A CB  1 
ATOM   2230 N  N   . TYR   A 1 278 ? -8.58225  46.49475 -12.14155 1.000 18.79839 ? 278 TYR   A N   1 
ATOM   2231 C  CA  . TYR   A 1 278 ? -8.76871  47.63079 -13.02808 1.000 15.42345 ? 278 TYR   A CA  1 
ATOM   2232 C  C   . TYR   A 1 278 ? -10.17738 48.19793 -12.85566 1.000 19.00844 ? 278 TYR   A C   1 
ATOM   2233 O  O   . TYR   A 1 278 ? -11.10738 47.47136 -12.49625 1.000 16.26083 ? 278 TYR   A O   1 
ATOM   2234 C  CB  . TYR   A 1 278 ? -8.54345  47.22312 -14.47603 1.000 13.70052 ? 278 TYR   A CB  1 
ATOM   2235 C  CG  . TYR   A 1 278 ? -7.10408  46.88749 -14.77493 1.000 17.60786 ? 278 TYR   A CG  1 
ATOM   2236 C  CD1 . TYR   A 1 278 ? -6.14775  47.89527 -14.93366 1.000 17.95454 ? 278 TYR   A CD1 1 
ATOM   2237 C  CD2 . TYR   A 1 278 ? -6.69397  45.57081 -14.88435 1.000 16.02713 ? 278 TYR   A CD2 1 
ATOM   2238 C  CE1 . TYR   A 1 278 ? -4.82523  47.58822 -15.21532 1.000 20.18224 ? 278 TYR   A CE1 1 
ATOM   2239 C  CE2 . TYR   A 1 278 ? -5.37921  45.25564 -15.15187 1.000 18.44604 ? 278 TYR   A CE2 1 
ATOM   2240 C  CZ  . TYR   A 1 278 ? -4.44893  46.26452 -15.31891 1.000 18.36355 ? 278 TYR   A CZ  1 
ATOM   2241 O  OH  . TYR   A 1 278 ? -3.14847  45.93559 -15.58387 1.000 22.25130 ? 278 TYR   A OH  1 
ATOM   2242 N  N   . PRO   A 1 279 ? -10.35798 49.50941 -13.08578 1.000 15.97298 ? 279 PRO   A N   1 
ATOM   2243 C  CA  . PRO   A 1 279 ? -11.66571 50.12168 -12.83541 1.000 15.35914 ? 279 PRO   A CA  1 
ATOM   2244 C  C   . PRO   A 1 279 ? -12.69849 49.78151 -13.90242 1.000 17.18925 ? 279 PRO   A C   1 
ATOM   2245 O  O   . PRO   A 1 279 ? -13.90146 49.78339 -13.62298 1.000 18.22218 ? 279 PRO   A O   1 
ATOM   2246 C  CB  . PRO   A 1 279 ? -11.34366 51.62660 -12.81321 1.000 17.68536 ? 279 PRO   A CB  1 
ATOM   2247 C  CG  . PRO   A 1 279 ? -10.16283 51.77040 -13.70897 1.000 18.06960 ? 279 PRO   A CG  1 
ATOM   2248 C  CD  . PRO   A 1 279 ? -9.35001  50.50212 -13.50948 1.000 19.59617 ? 279 PRO   A CD  1 
ATOM   2249 N  N   . THR   A 1 280 ? -12.25216 49.49791 -15.12502 1.000 14.91596 ? 280 THR   A N   1 
ATOM   2250 C  CA  . THR   A 1 280 ? -13.15383 49.16771 -16.22412 1.000 16.39497 ? 280 THR   A CA  1 
ATOM   2251 C  C   . THR   A 1 280 ? -12.60912 47.97985 -17.00086 1.000 17.88296 ? 280 THR   A C   1 
ATOM   2252 O  O   . THR   A 1 280 ? -11.42342 47.64522 -16.91984 1.000 17.20731 ? 280 THR   A O   1 
ATOM   2253 C  CB  . THR   A 1 280 ? -13.32501 50.32434 -17.21610 1.000 15.84287 ? 280 THR   A CB  1 
ATOM   2254 O  OG1 . THR   A 1 280 ? -12.07254 50.55483 -17.87854 1.000 17.41715 ? 280 THR   A OG1 1 
ATOM   2255 C  CG2 . THR   A 1 280 ? -13.78266 51.58873 -16.50318 1.000 17.20933 ? 280 THR   A CG2 1 
ATOM   2256 N  N   . TYR   A 1 281 ? -13.49858 47.37660 -17.79478 1.000 17.20843 ? 281 TYR   A N   1 
ATOM   2257 C  CA  . TYR   A 1 281 ? -13.10608 46.29783 -18.69234 1.000 16.42990 ? 281 TYR   A CA  1 
ATOM   2258 C  C   . TYR   A 1 281 ? -12.12995 46.79411 -19.75090 1.000 18.08585 ? 281 TYR   A C   1 
ATOM   2259 O  O   . TYR   A 1 281 ? -11.18873 46.08236 -20.12505 1.000 14.96719 ? 281 TYR   A O   1 
ATOM   2260 C  CB  . TYR   A 1 281 ? -14.35423 45.70872 -19.35215 1.000 16.70040 ? 281 TYR   A CB  1 
ATOM   2261 C  CG  . TYR   A 1 281 ? -14.18090 44.32624 -19.93452 1.000 15.95933 ? 281 TYR   A CG  1 
ATOM   2262 C  CD1 . TYR   A 1 281 ? -13.69596 44.14476 -21.22623 1.000 14.34333 ? 281 TYR   A CD1 1 
ATOM   2263 C  CD2 . TYR   A 1 281 ? -14.52757 43.19751 -19.19393 1.000 15.41987 ? 281 TYR   A CD2 1 
ATOM   2264 C  CE1 . TYR   A 1 281 ? -13.55066 42.87653 -21.75967 1.000 12.98179 ? 281 TYR   A CE1 1 
ATOM   2265 C  CE2 . TYR   A 1 281 ? -14.38677 41.93251 -19.71164 1.000 15.81603 ? 281 TYR   A CE2 1 
ATOM   2266 C  CZ  . TYR   A 1 281 ? -13.90150 41.77384 -20.99137 1.000 15.54319 ? 281 TYR   A CZ  1 
ATOM   2267 O  OH  . TYR   A 1 281 ? -13.78344 40.50131 -21.48283 1.000 15.02427 ? 281 TYR   A OH  1 
ATOM   2268 N  N   . ASP   A 1 282 ? -12.34917 48.01187 -20.25239 1.000 17.52463 ? 282 ASP   A N   1 
ATOM   2269 C  CA  . ASP   A 1 282 ? -11.48102 48.56032 -21.29029 1.000 20.99032 ? 282 ASP   A CA  1 
ATOM   2270 C  C   . ASP   A 1 282 ? -10.03546 48.69154 -20.81226 1.000 19.87320 ? 282 ASP   A C   1 
ATOM   2271 O  O   . ASP   A 1 282 ? -9.11117  48.60415 -21.62468 1.000 18.59596 ? 282 ASP   A O   1 
ATOM   2272 C  CB  . ASP   A 1 282 ? -12.00667 49.92633 -21.75259 1.000 18.87153 ? 282 ASP   A CB  1 
ATOM   2273 C  CG  . ASP   A 1 282 ? -13.48393 49.89539 -22.14688 1.000 21.39749 ? 282 ASP   A CG  1 
ATOM   2274 O  OD1 . ASP   A 1 282 ? -13.94031 48.92590 -22.79737 1.000 20.57524 ? 282 ASP   A OD1 1 
ATOM   2275 O  OD2 . ASP   A 1 282 ? -14.19889 50.85328 -21.79398 1.000 36.35984 ? 282 ASP   A OD2 1 
ATOM   2276 N  N   . ALA   A 1 283 ? -9.82204  48.89548 -19.50576 1.000 15.74073 ? 283 ALA   A N   1 
ATOM   2277 C  CA  . ALA   A 1 283 ? -8.48642  49.09738 -18.95128 1.000 17.92909 ? 283 ALA   A CA  1 
ATOM   2278 C  C   . ALA   A 1 283 ? -7.67088  47.81277 -18.79845 1.000 17.99927 ? 283 ALA   A C   1 
ATOM   2279 O  O   . ALA   A 1 283 ? -6.46197  47.89617 -18.55156 1.000 18.22665 ? 283 ALA   A O   1 
ATOM   2280 C  CB  . ALA   A 1 283 ? -8.59846  49.79101 -17.59233 1.000 15.74309 ? 283 ALA   A CB  1 
ATOM   2281 N  N   . ILE   A 1 284 ? -8.28533  46.63775 -18.91293 1.000 17.32302 ? 284 ILE   A N   1 
ATOM   2282 C  CA  . ILE   A 1 284 ? -7.56932  45.37069 -18.73870 1.000 18.26153 ? 284 ILE   A CA  1 
ATOM   2283 C  C   . ILE   A 1 284 ? -6.67042  45.11739 -19.94913 1.000 16.58772 ? 284 ILE   A C   1 
ATOM   2284 O  O   . ILE   A 1 284 ? -7.17403  45.02686 -21.07690 1.000 19.60712 ? 284 ILE   A O   1 
ATOM   2285 C  CB  . ILE   A 1 284 ? -8.54634  44.19724 -18.52716 1.000 13.35471 ? 284 ILE   A CB  1 
ATOM   2286 C  CG1 . ILE   A 1 284 ? -9.49337  44.46800 -17.35505 1.000 17.54557 ? 284 ILE   A CG1 1 
ATOM   2287 C  CG2 . ILE   A 1 284 ? -7.78915  42.92472 -18.26954 1.000 15.58117 ? 284 ILE   A CG2 1 
ATOM   2288 C  CD1 . ILE   A 1 284 ? -10.60136 43.42938 -17.21065 1.000 13.56953 ? 284 ILE   A CD1 1 
ATOM   2289 N  N   . PRO   A 1 285 ? -5.35897  44.96993 -19.76764 1.000 16.55612 ? 285 PRO   A N   1 
ATOM   2290 C  CA  . PRO   A 1 285 ? -4.46845  44.77736 -20.91811 1.000 19.17517 ? 285 PRO   A CA  1 
ATOM   2291 C  C   . PRO   A 1 285 ? -4.74590  43.47585 -21.64974 1.000 21.95076 ? 285 PRO   A C   1 
ATOM   2292 O  O   . PRO   A 1 285 ? -5.13999  42.46837 -21.05272 1.000 18.90217 ? 285 PRO   A O   1 
ATOM   2293 C  CB  . PRO   A 1 285 ? -3.06259  44.76129 -20.29253 1.000 20.72560 ? 285 PRO   A CB  1 
ATOM   2294 C  CG  . PRO   A 1 285 ? -3.20512  45.38226 -18.95617 1.000 20.64007 ? 285 PRO   A CG  1 
ATOM   2295 C  CD  . PRO   A 1 285 ? -4.61378  45.08109 -18.50081 1.000 20.35693 ? 285 PRO   A CD  1 
ATOM   2296 N  N   . LYS   A 1 286 ? -4.51796  43.51575 -22.96937 1.000 24.50346 ? 286 LYS   A N   1 
ATOM   2297 C  CA  . LYS   A 1 286 ? -4.67971  42.33317 -23.81327 1.000 20.03697 ? 286 LYS   A CA  1 
ATOM   2298 C  C   . LYS   A 1 286 ? -3.95538  41.12425 -23.24219 1.000 21.39519 ? 286 LYS   A C   1 
ATOM   2299 O  O   . LYS   A 1 286 ? -4.47080  40.00282 -23.29659 1.000 17.00977 ? 286 LYS   A O   1 
ATOM   2300 C  CB  . LYS   A 1 286 ? -4.15576  42.61730 -25.22192 1.000 23.95938 ? 286 LYS   A CB  1 
ATOM   2301 C  CG  . LYS   A 1 286 ? -5.06540  43.49956 -26.05566 1.000 31.37598 ? 286 LYS   A CG  1 
ATOM   2302 C  CD  . LYS   A 1 286 ? -4.96081  43.17384 -27.53909 1.000 41.21674 ? 286 LYS   A CD  1 
ATOM   2303 C  CE  . LYS   A 1 286 ? -6.31330  42.76422 -28.11634 1.000 38.88817 ? 286 LYS   A CE  1 
ATOM   2304 N  NZ  . LYS   A 1 286 ? -6.47627  43.27208 -29.50743 1.000 37.56316 ? 286 LYS   A NZ  1 
ATOM   2305 N  N   . GLN   A 1 287 ? -2.74139  41.32907 -22.71735 1.000 19.00419 ? 287 GLN   A N   1 
ATOM   2306 C  CA  . GLN   A 1 287 ? -1.92489  40.20401 -22.26381 1.000 18.57886 ? 287 GLN   A CA  1 
ATOM   2307 C  C   . GLN   A 1 287 ? -2.63832  39.38009 -21.19218 1.000 21.15338 ? 287 GLN   A C   1 
ATOM   2308 O  O   . GLN   A 1 287 ? -2.48926  38.15147 -21.16118 1.000 18.75561 ? 287 GLN   A O   1 
ATOM   2309 C  CB  . GLN   A 1 287 ? -0.57049  40.71816 -21.75708 1.000 19.10321 ? 287 GLN   A CB  1 
ATOM   2310 C  CG  . GLN   A 1 287 ? 0.44104   39.64743 -21.37839 1.000 19.41187 ? 287 GLN   A CG  1 
ATOM   2311 C  CD  . GLN   A 1 287 ? 0.74970   38.69453 -22.51614 1.000 21.78795 ? 287 GLN   A CD  1 
ATOM   2312 O  OE1 . GLN   A 1 287 ? 1.06515   39.11410 -23.63521 1.000 23.98791 ? 287 GLN   A OE1 1 
ATOM   2313 N  NE2 . GLN   A 1 287 ? 0.66914   37.40116 -22.23493 1.000 20.80146 ? 287 GLN   A NE2 1 
ATOM   2314 N  N   . LYS   A 1 288 ? -3.42936  40.03064 -20.32343 1.000 18.69209 ? 288 LYS   A N   1 
ATOM   2315 C  CA  . LYS   A 1 288 ? -4.18642  39.29468 -19.31355 1.000 16.56999 ? 288 LYS   A CA  1 
ATOM   2316 C  C   . LYS   A 1 288 ? -5.11377  38.27432 -19.95987 1.000 16.17474 ? 288 LYS   A C   1 
ATOM   2317 O  O   . LYS   A 1 288 ? -5.28427  37.16621 -19.44372 1.000 15.71137 ? 288 LYS   A O   1 
ATOM   2318 C  CB  . LYS   A 1 288 ? -4.99845  40.25670 -18.43619 1.000 18.02643 ? 288 LYS   A CB  1 
ATOM   2319 C  CG  . LYS   A 1 288 ? -4.16877  41.21704 -17.58132 1.000 18.83668 ? 288 LYS   A CG  1 
ATOM   2320 C  CD  . LYS   A 1 288 ? -3.32170  40.49142 -16.56549 1.000 21.36790 ? 288 LYS   A CD  1 
ATOM   2321 C  CE  . LYS   A 1 288 ? -4.08873  40.14831 -15.30490 1.000 18.18726 ? 288 LYS   A CE  1 
ATOM   2322 N  NZ  . LYS   A 1 288 ? -3.33297  39.15388 -14.47499 1.000 19.44196 ? 288 LYS   A NZ  1 
ATOM   2323 N  N   . PHE   A 1 289 ? -5.71774  38.62903 -21.09700 1.000 15.72777 ? 289 PHE   A N   1 
ATOM   2324 C  CA  . PHE   A 1 289 ? -6.62160  37.70546 -21.77578 1.000 16.82761 ? 289 PHE   A CA  1 
ATOM   2325 C  C   . PHE   A 1 289 ? -5.88027  36.49414 -22.31548 1.000 17.16447 ? 289 PHE   A C   1 
ATOM   2326 O  O   . PHE   A 1 289 ? -6.44717  35.39142 -22.35964 1.000 14.85588 ? 289 PHE   A O   1 
ATOM   2327 C  CB  . PHE   A 1 289 ? -7.37384  38.44517 -22.88552 1.000 12.34281 ? 289 PHE   A CB  1 
ATOM   2328 C  CG  . PHE   A 1 289 ? -8.26196  39.53112 -22.35285 1.000 18.25275 ? 289 PHE   A CG  1 
ATOM   2329 C  CD1 . PHE   A 1 289 ? -9.52570  39.23113 -21.85886 1.000 16.03680 ? 289 PHE   A CD1 1 
ATOM   2330 C  CD2 . PHE   A 1 289 ? -7.81218  40.84124 -22.27396 1.000 21.68965 ? 289 PHE   A CD2 1 
ATOM   2331 C  CE1 . PHE   A 1 289 ? -10.34517 40.22700 -21.33059 1.000 16.73846 ? 289 PHE   A CE1 1 
ATOM   2332 C  CE2 . PHE   A 1 289 ? -8.63317  41.84823 -21.74351 1.000 25.38392 ? 289 PHE   A CE2 1 
ATOM   2333 C  CZ  . PHE   A 1 289 ? -9.89697  41.53240 -21.27098 1.000 15.78287 ? 289 PHE   A CZ  1 
ATOM   2334 N  N   . LEU   A 1 290 ? -4.61204  36.67890 -22.70163 1.000 15.88357 ? 290 LEU   A N   1 
ATOM   2335 C  CA  . LEU   A 1 290 ? -3.78839  35.58894 -23.21027 1.000 20.32866 ? 290 LEU   A CA  1 
ATOM   2336 C  C   . LEU   A 1 290 ? -3.29635  34.69607 -22.07976 1.000 16.47128 ? 290 LEU   A C   1 
ATOM   2337 O  O   . LEU   A 1 290 ? -3.25359  33.47201 -22.23971 1.000 17.53507 ? 290 LEU   A O   1 
ATOM   2338 C  CB  . LEU   A 1 290 ? -2.59703  36.14370 -24.00720 1.000 15.48249 ? 290 LEU   A CB  1 
ATOM   2339 C  CG  . LEU   A 1 290 ? -2.96527  36.95519 -25.24810 1.000 19.14924 ? 290 LEU   A CG  1 
ATOM   2340 C  CD1 . LEU   A 1 290 ? -1.72760  37.48069 -25.97822 1.000 15.94980 ? 290 LEU   A CD1 1 
ATOM   2341 C  CD2 . LEU   A 1 290 ? -3.80907  36.11567 -26.19227 1.000 19.91466 ? 290 LEU   A CD2 1 
ATOM   2342 N  N   . ASP   A 1 291 ? -2.90112  35.28426 -20.94243 1.000 14.25574 ? 291 ASP   A N   1 
ATOM   2343 C  CA  . ASP   A 1 291 ? -2.57585  34.46122 -19.77897 1.000 14.92525 ? 291 ASP   A CA  1 
ATOM   2344 C  C   . ASP   A 1 291 ? -3.79526  33.65061 -19.33774 1.000 15.62686 ? 291 ASP   A C   1 
ATOM   2345 O  O   . ASP   A 1 291 ? -3.67865  32.47424 -18.97903 1.000 17.60772 ? 291 ASP   A O   1 
ATOM   2346 C  CB  . ASP   A 1 291 ? -2.07843  35.32443 -18.61127 1.000 18.85706 ? 291 ASP   A CB  1 
ATOM   2347 C  CG  . ASP   A 1 291 ? -0.94257  36.28026 -18.99008 1.000 25.03399 ? 291 ASP   A CG  1 
ATOM   2348 O  OD1 . ASP   A 1 291 ? -0.17447  36.00266 -19.94126 1.000 21.97564 ? 291 ASP   A OD1 1 
ATOM   2349 O  OD2 . ASP   A 1 291 ? -0.81992  37.32121 -18.29919 1.000 24.38004 ? 291 ASP   A OD2 1 
ATOM   2350 N  N   . GLN   A 1 292 ? -4.97952  34.26576 -19.36753 1.000 16.48887 ? 292 GLN   A N   1 
ATOM   2351 C  CA  . GLN   A 1 292 ? -6.19170  33.55224 -18.97311 1.000 15.75603 ? 292 GLN   A CA  1 
ATOM   2352 C  C   . GLN   A 1 292 ? -6.48664  32.40497 -19.92818 1.000 14.15647 ? 292 GLN   A C   1 
ATOM   2353 O  O   . GLN   A 1 292 ? -6.86326  31.30900 -19.49868 1.000 11.90709 ? 292 GLN   A O   1 
ATOM   2354 C  CB  . GLN   A 1 292 ? -7.37370  34.52018 -18.91184 1.000 11.56731 ? 292 GLN   A CB  1 
ATOM   2355 C  CG  . GLN   A 1 292 ? -8.70506  33.86448 -18.58356 1.000 12.27440 ? 292 GLN   A CG  1 
ATOM   2356 C  CD  . GLN   A 1 292 ? -9.83689  34.86189 -18.59301 1.000 11.75928 ? 292 GLN   A CD  1 
ATOM   2357 O  OE1 . GLN   A 1 292 ? -10.13286 35.46905 -19.62159 1.000 15.93577 ? 292 GLN   A OE1 1 
ATOM   2358 N  NE2 . GLN   A 1 292 ? -10.46252 35.05756 -17.44738 1.000 12.92944 ? 292 GLN   A NE2 1 
ATOM   2359 N  N   . ALA   A 1 293 ? -6.29996  32.63083 -21.22748 1.000 12.35631 ? 293 ALA   A N   1 
ATOM   2360 C  CA  . ALA   A 1 293 ? -6.61527  31.59188 -22.19620 1.000 12.24838 ? 293 ALA   A CA  1 
ATOM   2361 C  C   . ALA   A 1 293 ? -5.70880  30.38375 -22.00492 1.000 15.85026 ? 293 ALA   A C   1 
ATOM   2362 O  O   . ALA   A 1 293 ? -6.17188  29.23679 -22.06307 1.000 15.31292 ? 293 ALA   A O   1 
ATOM   2363 C  CB  . ALA   A 1 293 ? -6.50297  32.14232 -23.61884 1.000 11.59023 ? 293 ALA   A CB  1 
ATOM   2364 N  N   . ALA   A 1 294 ? -4.41811  30.61986 -21.74168 1.000 14.91284 ? 294 ALA   A N   1 
ATOM   2365 C  CA  . ALA   A 1 294 ? -3.50544  29.50467 -21.51801 1.000 16.28381 ? 294 ALA   A CA  1 
ATOM   2366 C  C   . ALA   A 1 294 ? -3.87230  28.75177 -20.24539 1.000 15.67238 ? 294 ALA   A C   1 
ATOM   2367 O  O   . ALA   A 1 294 ? -3.80022  27.51634 -20.20167 1.000 15.37165 ? 294 ALA   A O   1 
ATOM   2368 C  CB  . ALA   A 1 294 ? -2.05604  30.00210 -21.46877 1.000 15.85450 ? 294 ALA   A CB  1 
ATOM   2369 N  N   . ARG   A 1 295 ? -4.28875  29.47465 -19.20532 1.000 16.59634 ? 295 ARG   A N   1 
ATOM   2370 C  CA  . ARG   A 1 295 ? -4.77240  28.80629 -18.00341 1.000 13.06455 ? 295 ARG   A CA  1 
ATOM   2371 C  C   . ARG   A 1 295 ? -6.02218  27.97131 -18.29385 1.000 14.88543 ? 295 ARG   A C   1 
ATOM   2372 O  O   . ARG   A 1 295 ? -6.12676  26.82003 -17.85066 1.000 14.68173 ? 295 ARG   A O   1 
ATOM   2373 C  CB  . ARG   A 1 295 ? -5.03310  29.84798 -16.92066 1.000 15.12365 ? 295 ARG   A CB  1 
ATOM   2374 C  CG  . ARG   A 1 295 ? -5.95677  29.39108 -15.82517 1.000 16.72952 ? 295 ARG   A CG  1 
ATOM   2375 C  CD  . ARG   A 1 295 ? -5.28693  28.34395 -14.95809 1.000 15.89159 ? 295 ARG   A CD  1 
ATOM   2376 N  NE  . ARG   A 1 295 ? -5.67485  28.53168 -13.56740 1.000 16.19982 ? 295 ARG   A NE  1 
ATOM   2377 C  CZ  . ARG   A 1 295 ? -5.38358  27.68631 -12.58880 1.000 16.56496 ? 295 ARG   A CZ  1 
ATOM   2378 N  NH1 . ARG   A 1 295 ? -4.69900  26.58710 -12.85131 1.000 17.24442 ? 295 ARG   A NH1 1 
ATOM   2379 N  NH2 . ARG   A 1 295 ? -5.76725  27.95251 -11.35256 1.000 14.82000 ? 295 ARG   A NH2 1 
ATOM   2380 N  N   . TYR   A 1 296 ? -6.97474  28.52539 -19.04853 1.000 14.54022 ? 296 TYR   A N   1 
ATOM   2381 C  CA  . TYR   A 1 296 ? -8.16285  27.75710 -19.42775 1.000 14.88193 ? 296 TYR   A CA  1 
ATOM   2382 C  C   . TYR   A 1 296 ? -7.79576  26.54252 -20.26821 1.000 16.88652 ? 296 TYR   A C   1 
ATOM   2383 O  O   . TYR   A 1 296 ? -8.36440  25.45619 -20.08765 1.000 15.59036 ? 296 TYR   A O   1 
ATOM   2384 C  CB  . TYR   A 1 296 ? -9.13590  28.63360 -20.20472 1.000 12.23736 ? 296 TYR   A CB  1 
ATOM   2385 C  CG  . TYR   A 1 296 ? -10.24752 29.19693 -19.37433 1.000 14.23482 ? 296 TYR   A CG  1 
ATOM   2386 C  CD1 . TYR   A 1 296 ? -11.22634 28.36588 -18.83064 1.000 15.45503 ? 296 TYR   A CD1 1 
ATOM   2387 C  CD2 . TYR   A 1 296 ? -10.33717 30.56527 -19.14413 1.000 12.73856 ? 296 TYR   A CD2 1 
ATOM   2388 C  CE1 . TYR   A 1 296 ? -12.27432 28.89436 -18.08053 1.000 17.16137 ? 296 TYR   A CE1 1 
ATOM   2389 C  CE2 . TYR   A 1 296 ? -11.37672 31.10728 -18.40526 1.000 13.86042 ? 296 TYR   A CE2 1 
ATOM   2390 C  CZ  . TYR   A 1 296 ? -12.34655 30.26686 -17.87449 1.000 19.07954 ? 296 TYR   A CZ  1 
ATOM   2391 O  OH  . TYR   A 1 296 ? -13.37374 30.80114 -17.12310 1.000 13.58147 ? 296 TYR   A OH  1 
ATOM   2392 N  N   . ASP   A 1 297 ? -6.85369  26.71281 -21.19916 1.000 12.93425 ? 297 ASP   A N   1 
ATOM   2393 C  CA  . ASP   A 1 297 ? -6.36355  25.58942 -21.99025 1.000 14.71862 ? 297 ASP   A CA  1 
ATOM   2394 C  C   . ASP   A 1 297 ? -5.88258  24.45042 -21.10050 1.000 16.06169 ? 297 ASP   A C   1 
ATOM   2395 O  O   . ASP   A 1 297 ? -6.31198  23.30650 -21.26519 1.000 12.69237 ? 297 ASP   A O   1 
ATOM   2396 C  CB  . ASP   A 1 297 ? -5.23749  26.05121 -22.91878 1.000 17.03386 ? 297 ASP   A CB  1 
ATOM   2397 C  CG  . ASP   A 1 297 ? -4.76697  24.95072 -23.86106 1.000 19.05056 ? 297 ASP   A CG  1 
ATOM   2398 O  OD1 . ASP   A 1 297 ? -5.61375  24.23344 -24.45422 1.000 26.95520 ? 297 ASP   A OD1 1 
ATOM   2399 O  OD2 . ASP   A 1 297 ? -3.54083  24.80647 -24.00938 1.000 31.12363 ? 297 ASP   A OD2 1 
ATOM   2400 N  N   . ARG   A 1 298 ? -4.99397  24.75340 -20.14280 1.000 14.63331 ? 298 ARG   A N   1 
ATOM   2401 C  CA  . ARG   A 1 298 ? -4.47800  23.72502 -19.23680 1.000 18.04446 ? 298 ARG   A CA  1 
ATOM   2402 C  C   . ARG   A 1 298 ? -5.58763  23.13376 -18.37324 1.000 15.78436 ? 298 ARG   A C   1 
ATOM   2403 O  O   . ARG   A 1 298 ? -5.62596  21.92006 -18.13281 1.000 13.24429 ? 298 ARG   A O   1 
ATOM   2404 C  CB  . ARG   A 1 298 ? -3.37902  24.30465 -18.33477 1.000 11.52291 ? 298 ARG   A CB  1 
ATOM   2405 C  CG  . ARG   A 1 298 ? -2.11907  24.74724 -19.06880 1.000 21.64017 ? 298 ARG   A CG  1 
ATOM   2406 C  CD  . ARG   A 1 298 ? -0.99121  25.09880 -18.07857 1.000 21.26029 ? 298 ARG   A CD  1 
ATOM   2407 N  NE  . ARG   A 1 298 ? -1.40357  26.10993 -17.10439 1.000 22.01097 ? 298 ARG   A NE  1 
ATOM   2408 C  CZ  . ARG   A 1 298 ? -1.34474  27.42032 -17.32374 1.000 21.09690 ? 298 ARG   A CZ  1 
ATOM   2409 N  NH1 . ARG   A 1 298 ? -0.88663  27.87993 -18.48528 1.000 19.52871 ? 298 ARG   A NH1 1 
ATOM   2410 N  NH2 . ARG   A 1 298 ? -1.73165  28.27467 -16.38374 1.000 20.72940 ? 298 ARG   A NH2 1 
ATOM   2411 N  N   . LEU   A 1 299 ? -6.48611  23.98560 -17.88327 1.000 15.40166 ? 299 LEU   A N   1 
ATOM   2412 C  CA  . LEU   A 1 299 ? -7.50596  23.54041 -16.94185 1.000 16.56027 ? 299 LEU   A CA  1 
ATOM   2413 C  C   . LEU   A 1 299 ? -8.47120  22.55818 -17.59663 1.000 14.95066 ? 299 LEU   A C   1 
ATOM   2414 O  O   . LEU   A 1 299 ? -8.79490  21.51274 -17.01740 1.000 13.26402 ? 299 LEU   A O   1 
ATOM   2415 C  CB  . LEU   A 1 299 ? -8.25103  24.75810 -16.38475 1.000 15.12240 ? 299 LEU   A CB  1 
ATOM   2416 C  CG  . LEU   A 1 299 ? -9.38243  24.43769 -15.41614 1.000 16.81809 ? 299 LEU   A CG  1 
ATOM   2417 C  CD1 . LEU   A 1 299 ? -8.78732  24.09638 -14.05135 1.000 19.47036 ? 299 LEU   A CD1 1 
ATOM   2418 C  CD2 . LEU   A 1 299 ? -10.36419 25.60089 -15.31973 1.000 15.59822 ? 299 LEU   A CD2 1 
ATOM   2419 N  N   . PHE   A 1 300 ? -8.91731  22.85545 -18.81382 1.000 13.23565 ? 300 PHE   A N   1 
ATOM   2420 C  CA  . PHE   A 1 300 ? -9.89768  21.97290 -19.43279 1.000 13.98903 ? 300 PHE   A CA  1 
ATOM   2421 C  C   . PHE   A 1 300 ? -9.24361  20.72356 -20.00517 1.000 14.80655 ? 300 PHE   A C   1 
ATOM   2422 O  O   . PHE   A 1 300 ? -9.88197  19.67087 -20.06920 1.000 15.57787 ? 300 PHE   A O   1 
ATOM   2423 C  CB  . PHE   A 1 300 ? -10.69807 22.72786 -20.49752 1.000 11.02574 ? 300 PHE   A CB  1 
ATOM   2424 C  CG  . PHE   A 1 300 ? -11.94320 23.37615 -19.94193 1.000 14.64063 ? 300 PHE   A CG  1 
ATOM   2425 C  CD1 . PHE   A 1 300 ? -11.85511 24.55144 -19.19349 1.000 14.10993 ? 300 PHE   A CD1 1 
ATOM   2426 C  CD2 . PHE   A 1 300 ? -13.19250 22.78440 -20.11435 1.000 10.74947 ? 300 PHE   A CD2 1 
ATOM   2427 C  CE1 . PHE   A 1 300 ? -13.00515 25.14454 -18.62728 1.000 12.20838 ? 300 PHE   A CE1 1 
ATOM   2428 C  CE2 . PHE   A 1 300 ? -14.33893 23.36337 -19.56285 1.000 14.72027 ? 300 PHE   A CE2 1 
ATOM   2429 C  CZ  . PHE   A 1 300 ? -14.24430 24.55280 -18.81375 1.000 10.64969 ? 300 PHE   A CZ  1 
ATOM   2430 N  N   . LYS   A 1 301 ? -7.98042  20.80647 -20.40984 1.000 14.40327 ? 301 LYS   A N   1 
ATOM   2431 C  CA  . LYS   A 1 301 ? -7.24554  19.58717 -20.72477 1.000 16.93714 ? 301 LYS   A CA  1 
ATOM   2432 C  C   . LYS   A 1 301 ? -7.20723  18.66044 -19.51474 1.000 16.26796 ? 301 LYS   A C   1 
ATOM   2433 O  O   . LYS   A 1 301 ? -7.36690  17.44160 -19.65216 1.000 14.57572 ? 301 LYS   A O   1 
ATOM   2434 C  CB  . LYS   A 1 301 ? -5.82736  19.93167 -21.20043 1.000 17.09904 ? 301 LYS   A CB  1 
ATOM   2435 C  CG  . LYS   A 1 301 ? -5.38693  19.16557 -22.43613 1.000 29.50121 ? 301 LYS   A CG  1 
ATOM   2436 C  CD  . LYS   A 1 301 ? -4.16267  19.81720 -23.10201 1.000 33.54411 ? 301 LYS   A CD  1 
ATOM   2437 C  CE  . LYS   A 1 301 ? -4.44493  21.24355 -23.56610 1.000 28.86856 ? 301 LYS   A CE  1 
ATOM   2438 N  NZ  . LYS   A 1 301 ? -3.36314  21.82087 -24.43310 1.000 29.61299 ? 301 LYS   A NZ  1 
ATOM   2439 N  N   . LEU   A 1 302 ? -7.02140  19.22853 -18.31477 1.000 13.71242 ? 302 LEU   A N   1 
ATOM   2440 C  CA  . LEU   A 1 302 ? -7.04216  18.41678 -17.10039 1.000 16.01914 ? 302 LEU   A CA  1 
ATOM   2441 C  C   . LEU   A 1 302 ? -8.44080  17.87696 -16.81307 1.000 14.92862 ? 302 LEU   A C   1 
ATOM   2442 O  O   . LEU   A 1 302 ? -8.59441  16.70100 -16.45295 1.000 14.57118 ? 302 LEU   A O   1 
ATOM   2443 C  CB  . LEU   A 1 302 ? -6.51396  19.22510 -15.90984 1.000 12.81541 ? 302 LEU   A CB  1 
ATOM   2444 C  CG  . LEU   A 1 302 ? -6.64388  18.52460 -14.54820 1.000 22.00371 ? 302 LEU   A CG  1 
ATOM   2445 C  CD1 . LEU   A 1 302 ? -5.70556  17.29781 -14.43814 1.000 15.42299 ? 302 LEU   A CD1 1 
ATOM   2446 C  CD2 . LEU   A 1 302 ? -6.44352  19.48954 -13.35709 1.000 14.99391 ? 302 LEU   A CD2 1 
ATOM   2447 N  N   . TYR   A 1 303 ? -9.47700  18.70626 -16.98149 1.000 14.60463 ? 303 TYR   A N   1 
ATOM   2448 C  CA  . TYR   A 1 303 ? -10.84248 18.20790 -16.79525 1.000 18.19061 ? 303 TYR   A CA  1 
ATOM   2449 C  C   . TYR   A 1 303 ? -11.13243 17.04550 -17.73747 1.000 15.51211 ? 303 TYR   A C   1 
ATOM   2450 O  O   . TYR   A 1 303 ? -11.73485 16.04183 -17.33401 1.000 14.80352 ? 303 TYR   A O   1 
ATOM   2451 C  CB  . TYR   A 1 303 ? -11.87513 19.32222 -17.01079 1.000 11.56442 ? 303 TYR   A CB  1 
ATOM   2452 C  CG  . TYR   A 1 303 ? -11.89032 20.38452 -15.93720 1.000 13.63489 ? 303 TYR   A CG  1 
ATOM   2453 C  CD1 . TYR   A 1 303 ? -11.34750 20.14213 -14.67895 1.000 14.29681 ? 303 TYR   A CD1 1 
ATOM   2454 C  CD2 . TYR   A 1 303 ? -12.44563 21.63629 -16.18016 1.000 17.01997 ? 303 TYR   A CD2 1 
ATOM   2455 C  CE1 . TYR   A 1 303 ? -11.34796 21.10796 -13.69271 1.000 13.33657 ? 303 TYR   A CE1 1 
ATOM   2456 C  CE2 . TYR   A 1 303 ? -12.45462 22.62436 -15.19035 1.000 16.13460 ? 303 TYR   A CE2 1 
ATOM   2457 C  CZ  . TYR   A 1 303 ? -11.89875 22.35139 -13.95057 1.000 20.31621 ? 303 TYR   A CZ  1 
ATOM   2458 O  OH  . TYR   A 1 303 ? -11.90394 23.32299 -12.96718 1.000 14.50335 ? 303 TYR   A OH  1 
ATOM   2459 N  N   . GLU   A 1 304 ? -10.71347 17.15958 -18.99796 1.000 15.39655 ? 304 GLU   A N   1 
ATOM   2460 C  CA  . GLU   A 1 304 ? -10.94147 16.05823 -19.93147 1.000 16.30651 ? 304 GLU   A CA  1 
ATOM   2461 C  C   . GLU   A 1 304 ? -10.16400 14.81107 -19.51931 1.000 18.06418 ? 304 GLU   A C   1 
ATOM   2462 O  O   . GLU   A 1 304 ? -10.70787 13.70038 -19.55380 1.000 13.91546 ? 304 GLU   A O   1 
ATOM   2463 C  CB  . GLU   A 1 304 ? -10.58674 16.48257 -21.35536 1.000 17.62714 ? 304 GLU   A CB  1 
ATOM   2464 C  CG  . GLU   A 1 304 ? -11.73497 17.18793 -22.05390 1.000 17.74544 ? 304 GLU   A CG  1 
ATOM   2465 C  CD  . GLU   A 1 304 ? -11.52555 17.32324 -23.55131 1.000 21.89714 ? 304 GLU   A CD  1 
ATOM   2466 O  OE1 . GLU   A 1 304 ? -10.61645 18.07648 -23.95335 1.000 17.67149 ? 304 GLU   A OE1 1 
ATOM   2467 O  OE2 . GLU   A 1 304 ? -12.27778 16.68630 -24.32152 1.000 21.75556 ? 304 GLU   A OE2 1 
ATOM   2468 N  N   . LYS   A 1 305 ? -8.90153  14.97327 -19.10103 1.000 17.22549 ? 305 LYS   A N   1 
ATOM   2469 C  CA  . LYS   A 1 305 ? -8.14550  13.82804 -18.59760 1.000 16.64928 ? 305 LYS   A CA  1 
ATOM   2470 C  C   . LYS   A 1 305 ? -8.92969  13.08647 -17.51664 1.000 18.21929 ? 305 LYS   A C   1 
ATOM   2471 O  O   . LYS   A 1 305 ? -8.96213  11.84844 -17.48723 1.000 22.02850 ? 305 LYS   A O   1 
ATOM   2472 C  CB  . LYS   A 1 305 ? -6.79208  14.29760 -18.06332 1.000 12.72246 ? 305 LYS   A CB  1 
ATOM   2473 C  CG  . LYS   A 1 305 ? -5.85408  13.17941 -17.59443 1.000 20.16530 ? 305 LYS   A CG  1 
ATOM   2474 C  CD  . LYS   A 1 305 ? -4.82107  13.72839 -16.59570 1.000 21.44284 ? 305 LYS   A CD  1 
ATOM   2475 C  CE  . LYS   A 1 305 ? -3.53432  12.92063 -16.58145 1.000 21.23729 ? 305 LYS   A CE  1 
ATOM   2476 N  NZ  . LYS   A 1 305 ? -2.47271  13.56735 -15.72864 1.000 27.70580 ? 305 LYS   A NZ  1 
ATOM   2477 N  N   . LEU   A 1 306 ? -9.60810  13.83282 -16.64764 1.000 20.17000 ? 306 LEU   A N   1 
ATOM   2478 C  CA  . LEU   A 1 306 ? -10.35486 13.28268 -15.52847 1.000 16.86892 ? 306 LEU   A CA  1 
ATOM   2479 C  C   . LEU   A 1 306 ? -11.84857 13.15225 -15.81428 1.000 18.39755 ? 306 LEU   A C   1 
ATOM   2480 O  O   . LEU   A 1 306 ? -12.65380 13.10868 -14.86907 1.000 16.59452 ? 306 LEU   A O   1 
ATOM   2481 C  CB  . LEU   A 1 306 ? -10.13481 14.15977 -14.29789 1.000 19.95290 ? 306 LEU   A CB  1 
ATOM   2482 C  CG  . LEU   A 1 306 ? -8.69260  14.32835 -13.81875 1.000 18.41990 ? 306 LEU   A CG  1 
ATOM   2483 C  CD1 . LEU   A 1 306 ? -8.63195  15.26595 -12.63915 1.000 16.80939 ? 306 LEU   A CD1 1 
ATOM   2484 C  CD2 . LEU   A 1 306 ? -8.12647  12.97160 -13.44559 1.000 21.98324 ? 306 LEU   A CD2 1 
ATOM   2485 N  N   . SER   A 1 307 ? -12.24325 13.10250 -17.09047 1.000 16.16296 ? 307 SER   A N   1 
ATOM   2486 C  CA  . SER   A 1 307 ? -13.67267 13.13426 -17.40166 1.000 19.93680 ? 307 SER   A CA  1 
ATOM   2487 C  C   . SER   A 1 307 ? -14.42303 11.95053 -16.81004 1.000 19.05318 ? 307 SER   A C   1 
ATOM   2488 O  O   . SER   A 1 307 ? -15.63606 12.04023 -16.60024 1.000 19.01543 ? 307 SER   A O   1 
ATOM   2489 C  CB  . SER   A 1 307 ? -13.90015 13.17435 -18.90855 1.000 17.67978 ? 307 SER   A CB  1 
ATOM   2490 O  OG  . SER   A 1 307 ? -13.46285 11.97224 -19.48974 1.000 19.34466 ? 307 SER   A OG  1 
ATOM   2491 N  N   . ASP   A 1 308 ? -13.74024 10.84786 -16.52751 1.000 19.18533 ? 308 ASP   A N   1 
ATOM   2492 C  CA  . ASP   A 1 308 ? -14.43910 9.73882  -15.90424 1.000 23.55843 ? 308 ASP   A CA  1 
ATOM   2493 C  C   . ASP   A 1 308 ? -14.71442 9.99060  -14.42788 1.000 22.23212 ? 308 ASP   A C   1 
ATOM   2494 O  O   . ASP   A 1 308 ? -15.38928 9.17920  -13.79468 1.000 23.25983 ? 308 ASP   A O   1 
ATOM   2495 C  CB  . ASP   A 1 308 ? -13.65374 8.43223  -16.10949 1.000 25.68315 ? 308 ASP   A CB  1 
ATOM   2496 C  CG  . ASP   A 1 308 ? -12.28406 8.45423  -15.46796 1.000 30.34447 ? 308 ASP   A CG  1 
ATOM   2497 O  OD1 . ASP   A 1 308 ? -11.56350 9.48085  -15.56120 1.000 32.91389 ? 308 ASP   A OD1 1 
ATOM   2498 O  OD2 . ASP   A 1 308 ? -11.91468 7.42106  -14.87189 1.000 36.73690 ? 308 ASP   A OD2 1 
ATOM   2499 N  N   . LYS   A 1 309 ? -14.24463 11.10823 -13.87063 1.000 20.09335 ? 309 LYS   A N   1 
ATOM   2500 C  CA  . LYS   A 1 309 ? -14.50673 11.43951 -12.48033 1.000 19.52063 ? 309 LYS   A CA  1 
ATOM   2501 C  C   . LYS   A 1 309 ? -15.27569 12.74313 -12.31156 1.000 16.72854 ? 309 LYS   A C   1 
ATOM   2502 O  O   . LYS   A 1 309 ? -15.51542 13.16190 -11.17251 1.000 17.79202 ? 309 LYS   A O   1 
ATOM   2503 C  CB  . LYS   A 1 309 ? -13.18852 11.52394 -11.69577 1.000 20.19196 ? 309 LYS   A CB  1 
ATOM   2504 C  CG  . LYS   A 1 309 ? -12.36728 10.25580 -11.74566 1.000 24.99150 ? 309 LYS   A CG  1 
ATOM   2505 C  CD  . LYS   A 1 309 ? -10.89914 10.51151 -11.44860 1.000 25.70813 ? 309 LYS   A CD  1 
ATOM   2506 C  CE  . LYS   A 1 309 ? -10.11318 9.20439  -11.50274 1.000 31.89697 ? 309 LYS   A CE  1 
ATOM   2507 N  NZ  . LYS   A 1 309 ? -8.68474  9.42907  -11.89241 1.000 32.05830 ? 309 LYS   A NZ  1 
ATOM   2508 N  N   . ILE   A 1 310 ? -15.63922 13.40623 -13.40047 1.000 15.80723 ? 310 ILE   A N   1 
ATOM   2509 C  CA  . ILE   A 1 310 ? -16.30762 14.69798 -13.36666 1.000 18.13227 ? 310 ILE   A CA  1 
ATOM   2510 C  C   . ILE   A 1 310 ? -17.52921 14.59102 -14.25010 1.000 15.62823 ? 310 ILE   A C   1 
ATOM   2511 O  O   . ILE   A 1 310 ? -17.40070 14.29443 -15.43585 1.000 16.72766 ? 310 ILE   A O   1 
ATOM   2512 C  CB  . ILE   A 1 310 ? -15.40482 15.83256 -13.87532 1.000 19.55051 ? 310 ILE   A CB  1 
ATOM   2513 C  CG1 . ILE   A 1 310 ? -14.18278 16.02605 -12.97103 1.000 14.90654 ? 310 ILE   A CG1 1 
ATOM   2514 C  CG2 . ILE   A 1 310 ? -16.22711 17.11997 -14.07412 1.000 14.06539 ? 310 ILE   A CG2 1 
ATOM   2515 C  CD1 . ILE   A 1 310 ? -13.02706 16.75014 -13.67683 1.000 14.82651 ? 310 ILE   A CD1 1 
ATOM   2516 N  N   . SER   A 1 311 ? -18.70256 14.85934 -13.69395 1.000 17.95658 ? 311 SER   A N   1 
ATOM   2517 C  CA  . SER   A 1 311 ? -19.93151 14.80093 -14.47620 1.000 14.91034 ? 311 SER   A CA  1 
ATOM   2518 C  C   . SER   A 1 311 ? -20.38927 16.15501 -15.00264 1.000 14.60494 ? 311 SER   A C   1 
ATOM   2519 O  O   . SER   A 1 311 ? -21.24282 16.19789 -15.89353 1.000 12.40503 ? 311 SER   A O   1 
ATOM   2520 C  CB  . SER   A 1 311 ? -21.07008 14.19886 -13.64816 1.000 14.56866 ? 311 SER   A CB  1 
ATOM   2521 O  OG  . SER   A 1 311 ? -21.41938 15.08697 -12.59829 1.000 14.38150 ? 311 SER   A OG  1 
ATOM   2522 N  N   . ASN   A 1 312 ? -19.87083 17.25721 -14.47615 1.000 10.56219 ? 312 ASN   A N   1 
ATOM   2523 C  CA  . ASN   A 1 312 ? -20.39988 18.56229 -14.84069 1.000 11.09902 ? 312 ASN   A CA  1 
ATOM   2524 C  C   . ASN   A 1 312 ? -19.38332 19.64857 -14.52766 1.000 10.67871 ? 312 ASN   A C   1 
ATOM   2525 O  O   . ASN   A 1 312 ? -18.68900 19.59337 -13.50617 1.000 10.91435 ? 312 ASN   A O   1 
ATOM   2526 C  CB  . ASN   A 1 312 ? -21.71395 18.86024 -14.09695 1.000 11.08832 ? 312 ASN   A CB  1 
ATOM   2527 C  CG  . ASN   A 1 312 ? -22.06194 20.35602 -14.07286 1.000 13.93672 ? 312 ASN   A CG  1 
ATOM   2528 O  OD1 . ASN   A 1 312 ? -21.88920 21.03236 -13.04435 1.000 13.03098 ? 312 ASN   A OD1 1 
ATOM   2529 N  ND2 . ASN   A 1 312 ? -22.54640 20.88057 -15.21023 1.000 10.62983 ? 312 ASN   A ND2 1 
ATOM   2530 N  N   . VAL   A 1 313 ? -19.29694 20.62870 -15.42094 1.000 12.28646 ? 313 VAL   A N   1 
ATOM   2531 C  CA  . VAL   A 1 313 ? -18.52594 21.84394 -15.19171 1.000 10.76609 ? 313 VAL   A CA  1 
ATOM   2532 C  C   . VAL   A 1 313 ? -19.47618 23.02235 -15.38762 1.000 10.86929 ? 313 VAL   A C   1 
ATOM   2533 O  O   . VAL   A 1 313 ? -19.97555 23.24716 -16.49480 1.000 11.21298 ? 313 VAL   A O   1 
ATOM   2534 C  CB  . VAL   A 1 313 ? -17.30981 21.94004 -16.12637 1.000 11.29194 ? 313 VAL   A CB  1 
ATOM   2535 C  CG1 . VAL   A 1 313 ? -16.59140 23.28165 -15.93375 1.000 7.97479  ? 313 VAL   A CG1 1 
ATOM   2536 C  CG2 . VAL   A 1 313 ? -16.34906 20.76044 -15.87946 1.000 9.04426  ? 313 VAL   A CG2 1 
ATOM   2537 N  N   . THR   A 1 314 ? -19.73170 23.76233 -14.31553 1.000 10.27721 ? 314 THR   A N   1 
ATOM   2538 C  CA  . THR   A 1 314 ? -20.63437 24.90613 -14.33982 1.000 9.89617  ? 314 THR   A CA  1 
ATOM   2539 C  C   . THR   A 1 314 ? -19.84142 26.17168 -14.07870 1.000 11.18783 ? 314 THR   A C   1 
ATOM   2540 O  O   . THR   A 1 314 ? -19.06277 26.22231 -13.11799 1.000 10.37957 ? 314 THR   A O   1 
ATOM   2541 C  CB  . THR   A 1 314 ? -21.72472 24.75813 -13.27875 1.000 10.65040 ? 314 THR   A CB  1 
ATOM   2542 O  OG1 . THR   A 1 314 ? -22.50196 23.58934 -13.56745 1.000 10.74279 ? 314 THR   A OG1 1 
ATOM   2543 C  CG2 . THR   A 1 314 ? -22.61422 25.98341 -13.25717 1.000 7.94372  ? 314 THR   A CG2 1 
ATOM   2544 N  N   . PHE   A 1 315 ? -20.03634 27.17911 -14.93655 1.000 10.66727 ? 315 PHE   A N   1 
ATOM   2545 C  CA  . PHE   A 1 315 ? -19.49782 28.52628 -14.73217 1.000 12.44337 ? 315 PHE   A CA  1 
ATOM   2546 C  C   . PHE   A 1 315 ? -20.44692 29.34652 -13.86023 1.000 12.17076 ? 315 PHE   A C   1 
ATOM   2547 O  O   . PHE   A 1 315 ? -21.66888 29.27460 -14.01450 1.000 10.60560 ? 315 PHE   A O   1 
ATOM   2548 C  CB  . PHE   A 1 315 ? -19.30508 29.26345 -16.06727 1.000 10.52420 ? 315 PHE   A CB  1 
ATOM   2549 C  CG  . PHE   A 1 315 ? -18.26155 28.64781 -16.98648 1.000 11.56546 ? 315 PHE   A CG  1 
ATOM   2550 C  CD1 . PHE   A 1 315 ? -16.92988 29.00437 -16.88366 1.000 9.65114  ? 315 PHE   A CD1 1 
ATOM   2551 C  CD2 . PHE   A 1 315 ? -18.63113 27.74869 -17.97728 1.000 13.55274 ? 315 PHE   A CD2 1 
ATOM   2552 C  CE1 . PHE   A 1 315 ? -15.97382 28.45714 -17.73190 1.000 13.69443 ? 315 PHE   A CE1 1 
ATOM   2553 C  CE2 . PHE   A 1 315 ? -17.67794 27.19679 -18.83383 1.000 11.52483 ? 315 PHE   A CE2 1 
ATOM   2554 C  CZ  . PHE   A 1 315 ? -16.34333 27.55771 -18.70740 1.000 10.90136 ? 315 PHE   A CZ  1 
ATOM   2555 N  N   . TRP   A 1 316 ? -19.88286 30.17014 -12.97820 1.000 9.63739  ? 316 TRP   A N   1 
ATOM   2556 C  CA  . TRP   A 1 316 ? -20.70660 31.03703 -12.13945 1.000 12.31351 ? 316 TRP   A CA  1 
ATOM   2557 C  C   . TRP   A 1 316 ? -21.10875 32.31731 -12.88552 1.000 10.01454 ? 316 TRP   A C   1 
ATOM   2558 O  O   . TRP   A 1 316 ? -20.88549 33.43699 -12.43381 1.000 10.25870 ? 316 TRP   A O   1 
ATOM   2559 C  CB  . TRP   A 1 316 ? -19.98618 31.35377 -10.83563 1.000 11.29720 ? 316 TRP   A CB  1 
ATOM   2560 C  CG  . TRP   A 1 316 ? -20.98451 31.66456 -9.76829  1.000 14.22161 ? 316 TRP   A CG  1 
ATOM   2561 C  CD1 . TRP   A 1 316 ? -21.22327 32.87726 -9.19665  1.000 12.41670 ? 316 TRP   A CD1 1 
ATOM   2562 C  CD2 . TRP   A 1 316 ? -21.92886 30.74846 -9.18428  1.000 13.77082 ? 316 TRP   A CD2 1 
ATOM   2563 N  NE1 . TRP   A 1 316 ? -22.24805 32.77403 -8.27705  1.000 15.67224 ? 316 TRP   A NE1 1 
ATOM   2564 C  CE2 . TRP   A 1 316 ? -22.69383 31.47625 -8.24923  1.000 15.36176 ? 316 TRP   A CE2 1 
ATOM   2565 C  CE3 . TRP   A 1 316 ? -22.18635 29.38167 -9.34922  1.000 12.68428 ? 316 TRP   A CE3 1 
ATOM   2566 C  CZ2 . TRP   A 1 316 ? -23.70790 30.88158 -7.48259  1.000 15.39032 ? 316 TRP   A CZ2 1 
ATOM   2567 C  CZ3 . TRP   A 1 316 ? -23.19418 28.79328 -8.59425  1.000 14.11184 ? 316 TRP   A CZ3 1 
ATOM   2568 C  CH2 . TRP   A 1 316 ? -23.94587 29.54685 -7.67195  1.000 13.01275 ? 316 TRP   A CH2 1 
ATOM   2569 N  N   . GLY   A 1 317 ? -21.73686 32.12353 -14.03439 1.000 10.49009 ? 317 GLY   A N   1 
ATOM   2570 C  CA  . GLY   A 1 317 ? -22.22898 33.21369 -14.85619 1.000 9.37610  ? 317 GLY   A CA  1 
ATOM   2571 C  C   . GLY   A 1 317 ? -22.23362 32.80790 -16.31721 1.000 13.28304 ? 317 GLY   A C   1 
ATOM   2572 O  O   . GLY   A 1 317 ? -21.82211 31.70724 -16.68618 1.000 12.25986 ? 317 GLY   A O   1 
ATOM   2573 N  N   . ILE   A 1 318 ? -22.70152 33.73395 -17.15359 1.000 11.33919 ? 318 ILE   A N   1 
ATOM   2574 C  CA  . ILE   A 1 318 ? -22.86594 33.49725 -18.58947 1.000 9.78108  ? 318 ILE   A CA  1 
ATOM   2575 C  C   . ILE   A 1 318 ? -21.75272 34.16988 -19.39635 1.000 12.98921 ? 318 ILE   A C   1 
ATOM   2576 O  O   . ILE   A 1 318 ? -20.98075 33.49786 -20.08841 1.000 11.48623 ? 318 ILE   A O   1 
ATOM   2577 C  CB  . ILE   A 1 318 ? -24.25909 33.96555 -19.06374 1.000 11.52528 ? 318 ILE   A CB  1 
ATOM   2578 C  CG1 . ILE   A 1 318 ? -25.36287 33.29819 -18.23430 1.000 9.82315  ? 318 ILE   A CG1 1 
ATOM   2579 C  CG2 . ILE   A 1 318 ? -24.43943 33.70438 -20.54159 1.000 10.29135 ? 318 ILE   A CG2 1 
ATOM   2580 C  CD1 . ILE   A 1 318 ? -26.78315 33.68115 -18.67238 1.000 10.87294 ? 318 ILE   A CD1 1 
ATOM   2581 N  N   . ALA   A 1 319 ? -21.65482 35.50340 -19.31724 1.000 12.77886 ? 319 ALA   A N   1 
ATOM   2582 C  CA  . ALA   A 1 319 ? -20.64855 36.28433 -20.03597 1.000 11.09752 ? 319 ALA   A CA  1 
ATOM   2583 C  C   . ALA   A 1 319 ? -20.13002 37.40433 -19.13602 1.000 11.36023 ? 319 ALA   A C   1 
ATOM   2584 O  O   . ALA   A 1 319 ? -20.73256 37.74140 -18.10895 1.000 11.97565 ? 319 ALA   A O   1 
ATOM   2585 C  CB  . ALA   A 1 319 ? -21.21049 36.88043 -21.33824 1.000 11.75347 ? 319 ALA   A CB  1 
ATOM   2586 N  N   . ASP   A 1 320 ? -19.01059 38.01065 -19.55128 1.000 10.97823 ? 320 ASP   A N   1 
ATOM   2587 C  CA  . ASP   A 1 320 ? -18.27717 38.93118 -18.68742 1.000 13.83906 ? 320 ASP   A CA  1 
ATOM   2588 C  C   . ASP   A 1 320 ? -19.09090 40.16204 -18.26719 1.000 15.09117 ? 320 ASP   A C   1 
ATOM   2589 O  O   . ASP   A 1 320 ? -18.67361 40.86036 -17.33687 1.000 11.90316 ? 320 ASP   A O   1 
ATOM   2590 C  CB  . ASP   A 1 320 ? -16.97955 39.37528 -19.38102 1.000 14.32109 ? 320 ASP   A CB  1 
ATOM   2591 C  CG  . ASP   A 1 320 ? -15.84815 38.34393 -19.25413 1.000 14.07612 ? 320 ASP   A CG  1 
ATOM   2592 O  OD1 . ASP   A 1 320 ? -16.03166 37.31701 -18.54959 1.000 10.11307 ? 320 ASP   A OD1 1 
ATOM   2593 O  OD2 . ASP   A 1 320 ? -14.76651 38.56427 -19.87587 1.000 14.11581 ? 320 ASP   A OD2 1 
ATOM   2594 N  N   . ASN   A 1 321 ? -20.23537 40.44931 -18.90164 1.000 11.76031 ? 321 ASN   A N   1 
ATOM   2595 C  CA  . ASN   A 1 321 ? -20.99396 41.61279 -18.44534 1.000 15.67083 ? 321 ASN   A CA  1 
ATOM   2596 C  C   . ASN   A 1 321 ? -21.65405 41.39896 -17.08273 1.000 16.80174 ? 321 ASN   A C   1 
ATOM   2597 O  O   . ASN   A 1 321 ? -22.17999 42.36401 -16.51849 1.000 13.87029 ? 321 ASN   A O   1 
ATOM   2598 C  CB  . ASN   A 1 321 ? -22.05880 42.02196 -19.47818 1.000 11.16772 ? 321 ASN   A CB  1 
ATOM   2599 C  CG  . ASN   A 1 321 ? -22.98184 40.88376 -19.84599 1.000 15.93651 ? 321 ASN   A CG  1 
ATOM   2600 O  OD1 . ASN   A 1 321 ? -22.54328 39.74541 -19.97112 1.000 11.92942 ? 321 ASN   A OD1 1 
ATOM   2601 N  ND2 . ASN   A 1 321 ? -24.27838 41.18491 -20.01723 1.000 15.74905 ? 321 ASN   A ND2 1 
ATOM   2602 N  N   . HIS   A 1 322 ? -21.62426 40.18335 -16.52770 1.000 14.18130 ? 322 HIS   A N   1 
ATOM   2603 C  CA  . HIS   A 1 322 ? -22.24471 39.94104 -15.22946 1.000 12.29913 ? 322 HIS   A CA  1 
ATOM   2604 C  C   . HIS   A 1 322 ? -21.48348 38.84327 -14.49747 1.000 13.81955 ? 322 HIS   A C   1 
ATOM   2605 O  O   . HIS   A 1 322 ? -21.54663 37.67316 -14.89099 1.000 12.52332 ? 322 HIS   A O   1 
ATOM   2606 C  CB  . HIS   A 1 322 ? -23.72219 39.56365 -15.37562 1.000 15.21219 ? 322 HIS   A CB  1 
ATOM   2607 C  CG  . HIS   A 1 322 ? -24.37215 39.22064 -14.06641 1.000 19.16879 ? 322 HIS   A CG  1 
ATOM   2608 N  ND1 . HIS   A 1 322 ? -25.18361 40.10204 -13.38537 1.000 26.03522 ? 322 HIS   A ND1 1 
ATOM   2609 C  CD2 . HIS   A 1 322 ? -24.30058 38.10717 -13.29614 1.000 17.36427 ? 322 HIS   A CD2 1 
ATOM   2610 C  CE1 . HIS   A 1 322 ? -25.59403 39.54387 -12.25955 1.000 23.87219 ? 322 HIS   A CE1 1 
ATOM   2611 N  NE2 . HIS   A 1 322 ? -25.07344 38.33231 -12.18205 1.000 19.25101 ? 322 HIS   A NE2 1 
ATOM   2612 N  N   . THR   A 1 323 ? -20.81520 39.21311 -13.40459 1.000 12.60273 ? 323 THR   A N   1 
ATOM   2613 C  CA  . THR   A 1 323 ? -20.10465 38.26212 -12.55716 1.000 12.59631 ? 323 THR   A CA  1 
ATOM   2614 C  C   . THR   A 1 323 ? -20.04315 38.83509 -11.14756 1.000 14.10709 ? 323 THR   A C   1 
ATOM   2615 O  O   . THR   A 1 323 ? -19.71215 40.01190 -10.97720 1.000 12.53615 ? 323 THR   A O   1 
ATOM   2616 C  CB  . THR   A 1 323 ? -18.68681 37.99259 -13.07302 1.000 13.31757 ? 323 THR   A CB  1 
ATOM   2617 O  OG1 . THR   A 1 323 ? -17.92764 37.34054 -12.04765 1.000 12.05739 ? 323 THR   A OG1 1 
ATOM   2618 C  CG2 . THR   A 1 323 ? -17.99109 39.31519 -13.44405 1.000 9.37666  ? 323 THR   A CG2 1 
ATOM   2619 N  N   . TRP   A 1 324 ? -20.36577 38.00464 -10.15002 1.000 11.28324 ? 324 TRP   A N   1 
ATOM   2620 C  CA  . TRP   A 1 324 ? -20.23149 38.40070 -8.74912  1.000 16.20819 ? 324 TRP   A CA  1 
ATOM   2621 C  C   . TRP   A 1 324 ? -18.80621 38.80687 -8.38432  1.000 14.12963 ? 324 TRP   A C   1 
ATOM   2622 O  O   . TRP   A 1 324 ? -18.59920 39.43807 -7.34090  1.000 14.27014 ? 324 TRP   A O   1 
ATOM   2623 C  CB  . TRP   A 1 324 ? -20.67724 37.25944 -7.82125  1.000 15.22733 ? 324 TRP   A CB  1 
ATOM   2624 C  CG  . TRP   A 1 324 ? -19.60467 36.21457 -7.62733  1.000 16.58093 ? 324 TRP   A CG  1 
ATOM   2625 C  CD1 . TRP   A 1 324 ? -19.04029 35.43599 -8.59782  1.000 16.44691 ? 324 TRP   A CD1 1 
ATOM   2626 C  CD2 . TRP   A 1 324 ? -18.95619 35.85346 -6.39724  1.000 15.60994 ? 324 TRP   A CD2 1 
ATOM   2627 N  NE1 . TRP   A 1 324 ? -18.08822 34.60422 -8.04681  1.000 15.56118 ? 324 TRP   A NE1 1 
ATOM   2628 C  CE2 . TRP   A 1 324 ? -18.01164 34.84605 -6.70190  1.000 15.35554 ? 324 TRP   A CE2 1 
ATOM   2629 C  CE3 . TRP   A 1 324 ? -19.07697 36.28926 -5.07203  1.000 17.11885 ? 324 TRP   A CE3 1 
ATOM   2630 C  CZ2 . TRP   A 1 324 ? -17.20031 34.25599 -5.72784  1.000 16.79078 ? 324 TRP   A CZ2 1 
ATOM   2631 C  CZ3 . TRP   A 1 324 ? -18.27096 35.70530 -4.10476  1.000 18.43419 ? 324 TRP   A CZ3 1 
ATOM   2632 C  CH2 . TRP   A 1 324 ? -17.34494 34.69836 -4.44008  1.000 21.00383 ? 324 TRP   A CH2 1 
ATOM   2633 N  N   . LEU   A 1 325 ? -17.82049 38.43944 -9.19794  1.000 12.50929 ? 325 LEU   A N   1 
ATOM   2634 C  CA  . LEU   A 1 325 ? -16.44911 38.83643 -8.91618  1.000 15.17575 ? 325 LEU   A CA  1 
ATOM   2635 C  C   . LEU   A 1 325 ? -16.27599 40.34990 -8.93408  1.000 17.58296 ? 325 LEU   A C   1 
ATOM   2636 O  O   . LEU   A 1 325 ? -15.35763 40.86328 -8.28280  1.000 16.64791 ? 325 LEU   A O   1 
ATOM   2637 C  CB  . LEU   A 1 325 ? -15.50290 38.17544 -9.91679  1.000 14.88217 ? 325 LEU   A CB  1 
ATOM   2638 C  CG  . LEU   A 1 325 ? -15.35794 36.65727 -9.77431  1.000 17.15205 ? 325 LEU   A CG  1 
ATOM   2639 C  CD1 . LEU   A 1 325 ? -14.53890 36.10958 -10.94072 1.000 15.46466 ? 325 LEU   A CD1 1 
ATOM   2640 C  CD2 . LEU   A 1 325 ? -14.72961 36.26146 -8.42837  1.000 14.76127 ? 325 LEU   A CD2 1 
ATOM   2641 N  N   . ASP   A 1 326 ? -17.14927 41.07928 -9.63766  1.000 12.35823 ? 326 ASP   A N   1 
ATOM   2642 C  CA  . ASP   A 1 326 ? -17.05966 42.53417 -9.62011  1.000 14.48394 ? 326 ASP   A CA  1 
ATOM   2643 C  C   . ASP   A 1 326 ? -17.22834 43.09152 -8.21020  1.000 18.30736 ? 326 ASP   A C   1 
ATOM   2644 O  O   . ASP   A 1 326 ? -16.64135 44.13055 -7.88016  1.000 19.20880 ? 326 ASP   A O   1 
ATOM   2645 C  CB  . ASP   A 1 326 ? -18.10317 43.13475 -10.56537 1.000 15.31640 ? 326 ASP   A CB  1 
ATOM   2646 C  CG  . ASP   A 1 326 ? -17.72795 42.95631 -12.03748 1.000 18.92184 ? 326 ASP   A CG  1 
ATOM   2647 O  OD1 . ASP   A 1 326 ? -16.55629 42.62323 -12.31637 1.000 18.33140 ? 326 ASP   A OD1 1 
ATOM   2648 O  OD2 . ASP   A 1 326 ? -18.59616 43.13913 -12.91482 1.000 17.24416 ? 326 ASP   A OD2 1 
ATOM   2649 N  N   . SER   A 1 327 ? -18.01060 42.41843 -7.35881  1.000 17.89230 ? 327 SER   A N   1 
ATOM   2650 C  CA  . SER   A 1 327 ? -18.17343 42.88066 -5.98231  1.000 18.59307 ? 327 SER   A CA  1 
ATOM   2651 C  C   . SER   A 1 327 ? -16.87937 42.74211 -5.18326  1.000 22.58981 ? 327 SER   A C   1 
ATOM   2652 O  O   . SER   A 1 327 ? -16.71813 43.42161 -4.15996  1.000 20.10420 ? 327 SER   A O   1 
ATOM   2653 C  CB  . SER   A 1 327 ? -19.31728 42.12797 -5.29397  1.000 18.69247 ? 327 SER   A CB  1 
ATOM   2654 O  OG  . SER   A 1 327 ? -18.90221 40.82676 -4.89397  1.000 22.48802 ? 327 SER   A OG  1 
ATOM   2655 N  N   . ARG   A 1 328 ? -15.94602 41.90937 -5.65080  1.000 17.44828 ? 328 ARG   A N   1 
ATOM   2656 C  CA  . ARG   A 1 328 ? -14.61631 41.79074 -5.06839  1.000 19.93008 ? 328 ARG   A CA  1 
ATOM   2657 C  C   . ARG   A 1 328 ? -13.58048 42.66301 -5.77597  1.000 21.97754 ? 328 ARG   A C   1 
ATOM   2658 O  O   . ARG   A 1 328 ? -12.42268 42.71883 -5.33387  1.000 19.25479 ? 328 ARG   A O   1 
ATOM   2659 C  CB  . ARG   A 1 328 ? -14.16171 40.32426 -5.09541  1.000 16.32690 ? 328 ARG   A CB  1 
ATOM   2660 C  CG  . ARG   A 1 328 ? -14.77590 39.48755 -3.98738  1.000 23.03940 ? 328 ARG   A CG  1 
ATOM   2661 C  CD  . ARG   A 1 328 ? -15.28772 38.13161 -4.45950  1.000 20.24788 ? 328 ARG   A CD  1 
ATOM   2662 N  NE  . ARG   A 1 328 ? -14.24590 37.21629 -4.95725  1.000 22.57973 ? 328 ARG   A NE  1 
ATOM   2663 C  CZ  . ARG   A 1 328 ? -13.80232 36.12714 -4.32825  1.000 17.53362 ? 328 ARG   A CZ  1 
ATOM   2664 N  NH1 . ARG   A 1 328 ? -14.27131 35.77327 -3.13033  1.000 15.43936 ? 328 ARG   A NH1 1 
ATOM   2665 N  NH2 . ARG   A 1 328 ? -12.88381 35.37554 -4.91747  1.000 19.16017 ? 328 ARG   A NH2 1 
ATOM   2666 N  N   . ALA   A 1 329 ? -13.96510 43.35411 -6.85154  1.000 17.75402 ? 329 ALA   A N   1 
ATOM   2667 C  CA  . ALA   A 1 329 ? -12.99370 44.01584 -7.72981  1.000 19.29941 ? 329 ALA   A CA  1 
ATOM   2668 C  C   . ALA   A 1 329 ? -12.62418 45.38100 -7.14334  1.000 16.53498 ? 329 ALA   A C   1 
ATOM   2669 O  O   . ALA   A 1 329 ? -13.03559 46.44229 -7.61930  1.000 16.88515 ? 329 ALA   A O   1 
ATOM   2670 C  CB  . ALA   A 1 329 ? -13.55277 44.12688 -9.14639  1.000 13.73049 ? 329 ALA   A CB  1 
ATOM   2671 N  N   . ASP   A 1 330 ? -11.82273 45.35247 -6.08107  1.000 17.21928 ? 330 ASP   A N   1 
ATOM   2672 C  CA  . ASP   A 1 330 ? -11.42496 46.58928 -5.42117  1.000 17.97632 ? 330 ASP   A CA  1 
ATOM   2673 C  C   . ASP   A 1 330 ? -10.38899 47.32738 -6.26677  1.000 18.30930 ? 330 ASP   A C   1 
ATOM   2674 O  O   . ASP   A 1 330 ? -9.46656  46.71211 -6.81025  1.000 17.42114 ? 330 ASP   A O   1 
ATOM   2675 C  CB  . ASP   A 1 330 ? -10.84975 46.30149 -4.03379  1.000 18.69132 ? 330 ASP   A CB  1 
ATOM   2676 C  CG  . ASP   A 1 330 ? -11.80468 45.51028 -3.13602  1.000 19.63471 ? 330 ASP   A CG  1 
ATOM   2677 O  OD1 . ASP   A 1 330 ? -13.03391 45.57843 -3.34164  1.000 18.30610 ? 330 ASP   A OD1 1 
ATOM   2678 O  OD2 . ASP   A 1 330 ? -11.30692 44.82369 -2.21408  1.000 18.59532 ? 330 ASP   A OD2 1 
ATOM   2679 N  N   . VAL   A 1 331 ? -10.53543 48.64861 -6.37685  1.000 13.43929 ? 331 VAL   A N   1 
ATOM   2680 C  CA  . VAL   A 1 331 ? -9.61087  49.46864 -7.15998  1.000 17.16124 ? 331 VAL   A CA  1 
ATOM   2681 C  C   . VAL   A 1 331 ? -8.78615  50.31768 -6.20236  1.000 18.14699 ? 331 VAL   A C   1 
ATOM   2682 O  O   . VAL   A 1 331 ? -9.34185  51.07284 -5.39316  1.000 17.48825 ? 331 VAL   A O   1 
ATOM   2683 C  CB  . VAL   A 1 331 ? -10.34169 50.34969 -8.18580  1.000 15.80714 ? 331 VAL   A CB  1 
ATOM   2684 C  CG1 . VAL   A 1 331 ? -9.34655  51.02143 -9.12685  1.000 17.01612 ? 331 VAL   A CG1 1 
ATOM   2685 C  CG2 . VAL   A 1 331 ? -11.32629 49.52444 -8.97416  1.000 15.88920 ? 331 VAL   A CG2 1 
ATOM   2686 N  N   . TYR   A 1 332 ? -7.46485  50.19671 -6.30235  1.000 15.06768 ? 332 TYR   A N   1 
ATOM   2687 C  CA  . TYR   A 1 332 ? -6.52612  50.91780 -5.45168  1.000 18.13384 ? 332 TYR   A CA  1 
ATOM   2688 C  C   . TYR   A 1 332 ? -5.98110  52.12289 -6.20776  1.000 19.10727 ? 332 TYR   A C   1 
ATOM   2689 O  O   . TYR   A 1 332 ? -5.65056  52.02165 -7.39548  1.000 21.06827 ? 332 TYR   A O   1 
ATOM   2690 C  CB  . TYR   A 1 332 ? -5.37068  50.00218 -5.01197  1.000 18.31757 ? 332 TYR   A CB  1 
ATOM   2691 C  CG  . TYR   A 1 332 ? -5.77765  48.84503 -4.10599  1.000 21.12278 ? 332 TYR   A CG  1 
ATOM   2692 C  CD1 . TYR   A 1 332 ? -6.65228  47.85379 -4.55033  1.000 18.44055 ? 332 TYR   A CD1 1 
ATOM   2693 C  CD2 . TYR   A 1 332 ? -5.29290  48.75142 -2.80985  1.000 21.84351 ? 332 TYR   A CD2 1 
ATOM   2694 C  CE1 . TYR   A 1 332 ? -7.02936  46.81434 -3.74094  1.000 19.22804 ? 332 TYR   A CE1 1 
ATOM   2695 C  CE2 . TYR   A 1 332 ? -5.65944  47.70046 -1.98324  1.000 25.92221 ? 332 TYR   A CE2 1 
ATOM   2696 C  CZ  . TYR   A 1 332 ? -6.53261  46.73398 -2.45790  1.000 26.21974 ? 332 TYR   A CZ  1 
ATOM   2697 O  OH  . TYR   A 1 332 ? -6.90538  45.69023 -1.64390  1.000 20.86527 ? 332 TYR   A OH  1 
ATOM   2698 N  N   . TYR   A 1 333 ? -5.87524  53.25948 -5.51162  1.000 21.72750 ? 333 TYR   A N   1 
ATOM   2699 C  CA  . TYR   A 1 333 ? -5.42385  54.51724 -6.10565  1.000 22.98023 ? 333 TYR   A CA  1 
ATOM   2700 C  C   . TYR   A 1 333 ? -4.24185  55.08225 -5.32674  1.000 20.72260 ? 333 TYR   A C   1 
ATOM   2701 O  O   . TYR   A 1 333 ? -4.29270  55.16515 -4.09411  1.000 22.82634 ? 333 TYR   A O   1 
ATOM   2702 C  CB  . TYR   A 1 333 ? -6.56778  55.53830 -6.13055  1.000 20.79061 ? 333 TYR   A CB  1 
ATOM   2703 C  CG  . TYR   A 1 333 ? -7.70272  55.15912 -7.06109  1.000 21.85711 ? 333 TYR   A CG  1 
ATOM   2704 C  CD1 . TYR   A 1 333 ? -7.65786  55.49845 -8.40627  1.000 22.19809 ? 333 TYR   A CD1 1 
ATOM   2705 C  CD2 . TYR   A 1 333 ? -8.81033  54.45740 -6.59716  1.000 21.71538 ? 333 TYR   A CD2 1 
ATOM   2706 C  CE1 . TYR   A 1 333 ? -8.68270  55.16186 -9.27297  1.000 24.45106 ? 333 TYR   A CE1 1 
ATOM   2707 C  CE2 . TYR   A 1 333 ? -9.84826  54.12097 -7.45201  1.000 24.13869 ? 333 TYR   A CE2 1 
ATOM   2708 C  CZ  . TYR   A 1 333 ? -9.77682  54.47951 -8.79538  1.000 27.04491 ? 333 TYR   A CZ  1 
ATOM   2709 O  OH  . TYR   A 1 333 ? -10.79145 54.14735 -9.67093  1.000 25.80430 ? 333 TYR   A OH  1 
ATOM   2710 N  N   . ASP   A 1 334 ? -3.19117  55.49635 -6.03954  1.000 20.60783 ? 334 ASP   A N   1 
ATOM   2711 C  CA  . ASP   A 1 334 ? -2.05366  56.11739 -5.37509  1.000 24.50424 ? 334 ASP   A CA  1 
ATOM   2712 C  C   . ASP   A 1 334 ? -2.38658  57.57615 -5.06438  1.000 27.06470 ? 334 ASP   A C   1 
ATOM   2713 O  O   . ASP   A 1 334 ? -3.48731  58.06022 -5.34001  1.000 28.42326 ? 334 ASP   A O   1 
ATOM   2714 C  CB  . ASP   A 1 334 ? -0.77188  55.95486 -6.20586  1.000 23.68050 ? 334 ASP   A CB  1 
ATOM   2715 C  CG  . ASP   A 1 334 ? -0.79935  56.70955 -7.53959  1.000 26.93414 ? 334 ASP   A CG  1 
ATOM   2716 O  OD1 . ASP   A 1 334 ? -1.55029  57.68908 -7.69787  1.000 25.25426 ? 334 ASP   A OD1 1 
ATOM   2717 O  OD2 . ASP   A 1 334 ? -0.03724  56.31030 -8.44190  1.000 29.91875 ? 334 ASP   A OD2 1 
ATOM   2718 N  N   . ALA   A 1 335 ? -1.43650  58.28930 -4.46127  1.000 27.07754 ? 335 ALA   A N   1 
ATOM   2719 C  CA  . ALA   A 1 335 ? -1.70883  59.66746 -4.05709  1.000 28.01501 ? 335 ALA   A CA  1 
ATOM   2720 C  C   . ALA   A 1 335 ? -1.99024  60.58649 -5.24603  1.000 28.73513 ? 335 ALA   A C   1 
ATOM   2721 O  O   . ALA   A 1 335 ? -2.69813  61.58423 -5.08345  1.000 33.01059 ? 335 ALA   A O   1 
ATOM   2722 C  CB  . ALA   A 1 335 ? -0.55041  60.20926 -3.22657  1.000 25.64853 ? 335 ALA   A CB  1 
ATOM   2723 N  N   . ASN   A 1 336 ? -1.48039  60.26503 -6.43635  1.000 29.07326 ? 336 ASN   A N   1 
ATOM   2724 C  CA  . ASN   A 1 336 ? -1.77632  61.04330 -7.63310  1.000 30.83294 ? 336 ASN   A CA  1 
ATOM   2725 C  C   . ASN   A 1 336 ? -3.09886  60.66777 -8.28757  1.000 33.20676 ? 336 ASN   A C   1 
ATOM   2726 O  O   . ASN   A 1 336 ? -3.44014  61.25263 -9.32154  1.000 30.65975 ? 336 ASN   A O   1 
ATOM   2727 C  CB  . ASN   A 1 336 ? -0.65927  60.87983 -8.66172  1.000 31.38085 ? 336 ASN   A CB  1 
ATOM   2728 C  CG  . ASN   A 1 336 ? 0.65373   61.43810 -8.17688  1.000 35.58212 ? 336 ASN   A CG  1 
ATOM   2729 O  OD1 . ASN   A 1 336 ? 0.68494   62.42065 -7.44093  1.000 38.57405 ? 336 ASN   A OD1 1 
ATOM   2730 N  ND2 . ASN   A 1 336 ? 1.75062   60.80808 -8.58138  1.000 42.47312 ? 336 ASN   A ND2 1 
ATOM   2731 N  N   . GLY   A 1 337 ? -3.83947  59.70794 -7.73341  1.000 31.07757 ? 337 GLY   A N   1 
ATOM   2732 C  CA  . GLY   A 1 337 ? -5.07336  59.26914 -8.34719  1.000 26.40438 ? 337 GLY   A CA  1 
ATOM   2733 C  C   . GLY   A 1 337 ? -4.92059  58.27286 -9.47729  1.000 27.65293 ? 337 GLY   A C   1 
ATOM   2734 O  O   . GLY   A 1 337 ? -5.90557  57.99891 -10.17302 1.000 30.70792 ? 337 GLY   A O   1 
ATOM   2735 N  N   . ASN   A 1 338 ? -3.72369  57.73597 -9.69849  1.000 24.73422 ? 338 ASN   A N   1 
ATOM   2736 C  CA  . ASN   A 1 338 ? -3.53506  56.68279 -10.68480 1.000 25.05447 ? 338 ASN   A CA  1 
ATOM   2737 C  C   . ASN   A 1 338 ? -3.85904  55.31954 -10.07508 1.000 26.62147 ? 338 ASN   A C   1 
ATOM   2738 O  O   . ASN   A 1 338 ? -3.73815  55.11482 -8.86379  1.000 23.81423 ? 338 ASN   A O   1 
ATOM   2739 C  CB  . ASN   A 1 338 ? -2.10319  56.69421 -11.21108 1.000 24.88094 ? 338 ASN   A CB  1 
ATOM   2740 C  CG  . ASN   A 1 338 ? -1.65746  58.07998 -11.64958 1.000 35.16026 ? 338 ASN   A CG  1 
ATOM   2741 O  OD1 . ASN   A 1 338 ? -2.34991  58.75374 -12.40435 1.000 37.00332 ? 338 ASN   A OD1 1 
ATOM   2742 N  ND2 . ASN   A 1 338 ? -0.50140  58.51589 -11.15979 1.000 41.07683 ? 338 ASN   A ND2 1 
ATOM   2743 N  N   . VAL   A 1 339 ? -4.26836  54.37981 -10.93550 1.000 22.57188 ? 339 VAL   A N   1 
ATOM   2744 C  CA  . VAL   A 1 339 ? -4.70251  53.04975 -10.50674 1.000 25.20860 ? 339 VAL   A CA  1 
ATOM   2745 C  C   . VAL   A 1 339 ? -3.48824  52.18631 -10.17757 1.000 21.65859 ? 339 VAL   A C   1 
ATOM   2746 O  O   . VAL   A 1 339 ? -2.48966  52.19470 -10.90216 1.000 27.17013 ? 339 VAL   A O   1 
ATOM   2747 C  CB  . VAL   A 1 339 ? -5.57445  52.40334 -11.60285 1.000 24.02314 ? 339 VAL   A CB  1 
ATOM   2748 C  CG1 . VAL   A 1 339 ? -5.63955  50.89332 -11.43745 1.000 17.76476 ? 339 VAL   A CG1 1 
ATOM   2749 C  CG2 . VAL   A 1 339 ? -6.97375  53.02155 -11.61332 1.000 18.20201 ? 339 VAL   A CG2 1 
ATOM   2750 N  N   . VAL   A 1 340 ? -3.56513  51.43351 -9.08138  1.000 21.26762 ? 340 VAL   A N   1 
ATOM   2751 C  CA  . VAL   A 1 340 ? -2.47614  50.55938 -8.64356  1.000 21.67965 ? 340 VAL   A CA  1 
ATOM   2752 C  C   . VAL   A 1 340 ? -2.95632  49.11434 -8.71302  1.000 21.31292 ? 340 VAL   A C   1 
ATOM   2753 O  O   . VAL   A 1 340 ? -3.90205  48.72995 -8.01074  1.000 19.57888 ? 340 VAL   A O   1 
ATOM   2754 C  CB  . VAL   A 1 340 ? -1.98866  50.89128 -7.22002  1.000 23.17276 ? 340 VAL   A CB  1 
ATOM   2755 C  CG1 . VAL   A 1 340 ? -0.74875  50.04963 -6.86492  1.000 15.57663 ? 340 VAL   A CG1 1 
ATOM   2756 C  CG2 . VAL   A 1 340 ? -1.69496  52.38837 -7.06243  1.000 17.33126 ? 340 VAL   A CG2 1 
ATOM   2757 N  N   . VAL   A 1 341 ? -2.29249  48.31209 -9.54496  1.000 21.13947 ? 341 VAL   A N   1 
ATOM   2758 C  CA  . VAL   A 1 341 ? -2.60636  46.89359 -9.68199  1.000 20.20516 ? 341 VAL   A CA  1 
ATOM   2759 C  C   . VAL   A 1 341 ? -1.47852  45.98945 -9.19630  1.000 22.96944 ? 341 VAL   A C   1 
ATOM   2760 O  O   . VAL   A 1 341 ? -1.70724  44.77922 -9.02937  1.000 22.09006 ? 341 VAL   A O   1 
ATOM   2761 C  CB  . VAL   A 1 341 ? -2.98286  46.54385 -11.13755 1.000 19.79728 ? 341 VAL   A CB  1 
ATOM   2762 C  CG1 . VAL   A 1 341 ? -4.28941  47.24397 -11.52207 1.000 16.78375 ? 341 VAL   A CG1 1 
ATOM   2763 C  CG2 . VAL   A 1 341 ? -1.86232  46.95886 -12.08601 1.000 18.96117 ? 341 VAL   A CG2 1 
ATOM   2764 N  N   . ASP   A 1 342 ? -0.28044  46.52449 -8.96243  1.000 26.25556 ? 342 ASP   A N   1 
ATOM   2765 C  CA  . ASP   A 1 342 ? 0.80952   45.73219 -8.38430  1.000 27.63035 ? 342 ASP   A CA  1 
ATOM   2766 C  C   . ASP   A 1 342 ? 0.48442   45.41042 -6.93039  1.000 23.91739 ? 342 ASP   A C   1 
ATOM   2767 O  O   . ASP   A 1 342 ? 0.26657   46.33394 -6.13279  1.000 23.86811 ? 342 ASP   A O   1 
ATOM   2768 C  CB  . ASP   A 1 342 ? 2.12722   46.50306 -8.50822  1.000 31.33129 ? 342 ASP   A CB  1 
ATOM   2769 C  CG  . ASP   A 1 342 ? 3.33098   45.78241 -7.87145  1.000 36.91698 ? 342 ASP   A CG  1 
ATOM   2770 O  OD1 . ASP   A 1 342 ? 3.18615   44.92923 -6.95667  1.000 39.97846 ? 342 ASP   A OD1 1 
ATOM   2771 O  OD2 . ASP   A 1 342 ? 4.45767   46.09619 -8.30688  1.000 47.06639 ? 342 ASP   A OD2 1 
ATOM   2772 N  N   . PRO   A 1 343 ? 0.45615   44.13374 -6.53496  1.000 29.31841 ? 343 PRO   A N   1 
ATOM   2773 C  CA  . PRO   A 1 343 ? -0.06831  43.77607 -5.20389  1.000 30.84866 ? 343 PRO   A CA  1 
ATOM   2774 C  C   . PRO   A 1 343 ? 0.78251   44.23648 -4.02120  1.000 33.11436 ? 343 PRO   A C   1 
ATOM   2775 O  O   . PRO   A 1 343 ? 0.28451   44.21816 -2.88546  1.000 31.75480 ? 343 PRO   A O   1 
ATOM   2776 C  CB  . PRO   A 1 343 ? -0.15603  42.24037 -5.25275  1.000 31.30552 ? 343 PRO   A CB  1 
ATOM   2777 C  CG  . PRO   A 1 343 ? 0.75226   41.84291 -6.34929  1.000 35.69922 ? 343 PRO   A CG  1 
ATOM   2778 C  CD  . PRO   A 1 343 ? 0.68949   42.94894 -7.36899  1.000 31.71733 ? 343 PRO   A CD  1 
ATOM   2779 N  N   . ASN   A 1 344 ? 2.02107   44.67199 -4.21824  1.000 31.27026 ? 344 ASN   A N   1 
ATOM   2780 C  CA  . ASN   A 1 344 ? 2.80496   45.18087 -3.09519  1.000 38.45324 ? 344 ASN   A CA  1 
ATOM   2781 C  C   . ASN   A 1 344 ? 3.02900   46.68412 -3.14431  1.000 35.57423 ? 344 ASN   A C   1 
ATOM   2782 O  O   . ASN   A 1 344 ? 3.60483   47.23849 -2.20113  1.000 38.14040 ? 344 ASN   A O   1 
ATOM   2783 C  CB  . ASN   A 1 344 ? 4.16442   44.47111 -3.01661  1.000 43.05947 ? 344 ASN   A CB  1 
ATOM   2784 C  CG  . ASN   A 1 344 ? 4.04271   42.96884 -3.09480  1.000 48.29184 ? 344 ASN   A CG  1 
ATOM   2785 O  OD1 . ASN   A 1 344 ? 3.55035   42.33004 -2.16121  1.000 54.86582 ? 344 ASN   A OD1 1 
ATOM   2786 N  ND2 . ASN   A 1 344 ? 4.50737   42.38830 -4.19896  1.000 45.83420 ? 344 ASN   A ND2 1 
ATOM   2787 N  N   . ALA   A 1 345 ? 2.57711   47.35125 -4.20140  1.000 27.20333 ? 345 ALA   A N   1 
ATOM   2788 C  CA  . ALA   A 1 345 ? 2.94886   48.72444 -4.46994  1.000 25.96981 ? 345 ALA   A CA  1 
ATOM   2789 C  C   . ALA   A 1 345 ? 2.23765   49.69800 -3.53001  1.000 22.86534 ? 345 ALA   A C   1 
ATOM   2790 O  O   . ALA   A 1 345 ? 1.18332   49.38722 -2.97075  1.000 19.63837 ? 345 ALA   A O   1 
ATOM   2791 C  CB  . ALA   A 1 345 ? 2.62533   49.07002 -5.92267  1.000 27.96387 ? 345 ALA   A CB  1 
ATOM   2792 N  N   . PRO   A 1 346 ? 2.80123   50.89348 -3.34766  1.000 21.95055 ? 346 PRO   A N   1 
ATOM   2793 C  CA  . PRO   A 1 346 ? 2.14959   51.89757 -2.49722  1.000 20.45134 ? 346 PRO   A CA  1 
ATOM   2794 C  C   . PRO   A 1 346 ? 0.79589   52.32245 -3.04692  1.000 24.44209 ? 346 PRO   A C   1 
ATOM   2795 O  O   . PRO   A 1 346 ? 0.53279   52.26158 -4.25317  1.000 21.77643 ? 346 PRO   A O   1 
ATOM   2796 C  CB  . PRO   A 1 346 ? 3.13153   53.07742 -2.51339  1.000 24.73609 ? 346 PRO   A CB  1 
ATOM   2797 C  CG  . PRO   A 1 346 ? 4.40808   52.53954 -3.05747  1.000 23.39558 ? 346 PRO   A CG  1 
ATOM   2798 C  CD  . PRO   A 1 346 ? 4.07090   51.37674 -3.91888  1.000 22.00298 ? 346 PRO   A CD  1 
ATOM   2799 N  N   . TYR   A 1 347 ? -0.06217  52.77870 -2.14091  1.000 20.08648 ? 347 TYR   A N   1 
ATOM   2800 C  CA  . TYR   A 1 347 ? -1.35595  53.29655 -2.54534  1.000 22.59021 ? 347 TYR   A CA  1 
ATOM   2801 C  C   . TYR   A 1 347 ? -1.93499  54.09138 -1.38661  1.000 25.55591 ? 347 TYR   A C   1 
ATOM   2802 O  O   . TYR   A 1 347 ? -1.55166  53.91209 -0.22604  1.000 22.15880 ? 347 TYR   A O   1 
ATOM   2803 C  CB  . TYR   A 1 347 ? -2.30321  52.17382 -2.98668  1.000 21.35807 ? 347 TYR   A CB  1 
ATOM   2804 C  CG  . TYR   A 1 347 ? -2.97035  51.42157 -1.85633  1.000 25.03370 ? 347 TYR   A CG  1 
ATOM   2805 C  CD1 . TYR   A 1 347 ? -4.21037  51.82875 -1.35746  1.000 23.38552 ? 347 TYR   A CD1 1 
ATOM   2806 C  CD2 . TYR   A 1 347 ? -2.37670  50.29256 -1.29661  1.000 22.22561 ? 347 TYR   A CD2 1 
ATOM   2807 C  CE1 . TYR   A 1 347 ? -4.82696  51.14222 -0.32920  1.000 22.25184 ? 347 TYR   A CE1 1 
ATOM   2808 C  CE2 . TYR   A 1 347 ? -2.99719  49.59227 -0.26804  1.000 19.30930 ? 347 TYR   A CE2 1 
ATOM   2809 C  CZ  . TYR   A 1 347 ? -4.21681  50.02048 0.20292   1.000 24.01597 ? 347 TYR   A CZ  1 
ATOM   2810 O  OH  . TYR   A 1 347 ? -4.82676  49.33950 1.22390   1.000 27.20998 ? 347 TYR   A OH  1 
ATOM   2811 N  N   . ALA   A 1 348 ? -2.86160  54.97980 -1.72520  1.000 23.38728 ? 348 ALA   A N   1 
ATOM   2812 C  CA  . ALA   A 1 348 ? -3.45930  55.89324 -0.76885  1.000 24.89468 ? 348 ALA   A CA  1 
ATOM   2813 C  C   . ALA   A 1 348 ? -4.86692  55.50233 -0.35976  1.000 22.94772 ? 348 ALA   A C   1 
ATOM   2814 O  O   . ALA   A 1 348 ? -5.19650  55.59763 0.82011   1.000 24.35496 ? 348 ALA   A O   1 
ATOM   2815 C  CB  . ALA   A 1 348 ? -3.47391  57.31574 -1.33858  1.000 24.09592 ? 348 ALA   A CB  1 
ATOM   2816 N  N   . LYS   A 1 349 ? -5.71375  55.07622 -1.29777  1.000 24.42783 ? 349 LYS   A N   1 
ATOM   2817 C  CA  . LYS   A 1 349 ? -7.08426  54.70419 -0.96700  1.000 23.61431 ? 349 LYS   A CA  1 
ATOM   2818 C  C   . LYS   A 1 349 ? -7.54241  53.57399 -1.88190  1.000 26.07582 ? 349 LYS   A C   1 
ATOM   2819 O  O   . LYS   A 1 349 ? -6.93749  53.30270 -2.92755  1.000 23.55899 ? 349 LYS   A O   1 
ATOM   2820 C  CB  . LYS   A 1 349 ? -8.03914  55.90434 -1.06612  1.000 25.05154 ? 349 LYS   A CB  1 
ATOM   2821 C  CG  . LYS   A 1 349 ? -8.27764  56.42106 -2.48475  1.000 28.77931 ? 349 LYS   A CG  1 
ATOM   2822 C  CD  . LYS   A 1 349 ? -9.29486  57.58230 -2.49723  1.000 43.64946 ? 349 LYS   A CD  1 
ATOM   2823 C  CE  . LYS   A 1 349 ? -9.94513  57.80955 -3.87967  1.000 40.40899 ? 349 LYS   A CE  1 
ATOM   2824 N  NZ  . LYS   A 1 349 ? -9.25609  58.83121 -4.74052  1.000 33.46459 ? 349 LYS   A NZ  1 
ATOM   2825 N  N   . VAL   A 1 350 ? -8.61619  52.90264 -1.46046  1.000 20.19602 ? 350 VAL   A N   1 
ATOM   2826 C  CA  . VAL   A 1 350 ? -9.21828  51.80961 -2.21330  1.000 24.07309 ? 350 VAL   A CA  1 
ATOM   2827 C  C   . VAL   A 1 350 ? -10.70774 52.09695 -2.40596  1.000 25.83389 ? 350 VAL   A C   1 
ATOM   2828 O  O   . VAL   A 1 350 ? -11.37731 52.61484 -1.50244  1.000 22.39291 ? 350 VAL   A O   1 
ATOM   2829 C  CB  . VAL   A 1 350 ? -8.98861  50.44671 -1.51236  1.000 22.31815 ? 350 VAL   A CB  1 
ATOM   2830 C  CG1 . VAL   A 1 350 ? -9.40432  50.51564 -0.05351  1.000 28.56783 ? 350 VAL   A CG1 1 
ATOM   2831 C  CG2 . VAL   A 1 350 ? -9.74100  49.35202 -2.21751  1.000 21.65286 ? 350 VAL   A CG2 1 
ATOM   2832 N  N   . GLU   A 1 351 ? -11.22142 51.78778 -3.59668  1.000 18.23863 ? 351 GLU   A N   1 
ATOM   2833 C  CA  . GLU   A 1 351 ? -12.65448 51.88419 -3.88046  1.000 22.29278 ? 351 GLU   A CA  1 
ATOM   2834 C  C   . GLU   A 1 351 ? -13.20989 50.46193 -3.98244  1.000 22.12730 ? 351 GLU   A C   1 
ATOM   2835 O  O   . GLU   A 1 351 ? -13.12855 49.82502 -5.03764  1.000 14.96130 ? 351 GLU   A O   1 
ATOM   2836 C  CB  . GLU   A 1 351 ? -12.89569 52.70025 -5.14516  1.000 18.78928 ? 351 GLU   A CB  1 
ATOM   2837 C  CG  . GLU   A 1 351 ? -12.86968 54.20798 -4.87971  1.000 30.13252 ? 351 GLU   A CG  1 
ATOM   2838 C  CD  . GLU   A 1 351 ? -13.06016 55.04242 -6.13667  1.000 36.24637 ? 351 GLU   A CD  1 
ATOM   2839 O  OE1 . GLU   A 1 351 ? -12.57630 56.19864 -6.16331  1.000 36.89813 ? 351 GLU   A OE1 1 
ATOM   2840 O  OE2 . GLU   A 1 351 ? -13.69731 54.54363 -7.09483  1.000 39.00053 ? 351 GLU   A OE2 1 
ATOM   2841 N  N   . LYS   A 1 352 ? -13.78688 49.97508 -2.88283  1.000 16.90771 ? 352 LYS   A N   1 
ATOM   2842 C  CA  . LYS   A 1 352 ? -14.12318 48.56162 -2.76885  1.000 22.48516 ? 352 LYS   A CA  1 
ATOM   2843 C  C   . LYS   A 1 352 ? -15.24209 48.18164 -3.73280  1.000 21.32898 ? 352 LYS   A C   1 
ATOM   2844 O  O   . LYS   A 1 352 ? -16.26132 48.87287 -3.82174  1.000 22.13662 ? 352 LYS   A O   1 
ATOM   2845 C  CB  . LYS   A 1 352 ? -14.52509 48.22770 -1.33771  1.000 26.36428 ? 352 LYS   A CB  1 
ATOM   2846 C  CG  . LYS   A 1 352 ? -13.34341 48.16594 -0.35722  1.000 34.37274 ? 352 LYS   A CG  1 
ATOM   2847 C  CD  . LYS   A 1 352 ? -13.34944 46.86500 0.46119   1.000 43.48245 ? 352 LYS   A CD  1 
ATOM   2848 C  CE  . LYS   A 1 352 ? -12.42873 46.96693 1.67397   1.000 49.07577 ? 352 LYS   A CE  1 
ATOM   2849 N  NZ  . LYS   A 1 352 ? -13.09218 46.47231 2.91753   1.000 50.91911 ? 352 LYS   A NZ  1 
ATOM   2850 N  N   . GLY   A 1 353 ? -15.03615 47.08639 -4.46797  1.000 20.93417 ? 353 GLY   A N   1 
ATOM   2851 C  CA  . GLY   A 1 353 ? -16.06372 46.56860 -5.35511  1.000 19.57581 ? 353 GLY   A CA  1 
ATOM   2852 C  C   . GLY   A 1 353 ? -16.48821 47.48880 -6.47923  1.000 20.34997 ? 353 GLY   A C   1 
ATOM   2853 O  O   . GLY   A 1 353 ? -17.62221 47.37639 -6.95360  1.000 19.41941 ? 353 GLY   A O   1 
ATOM   2854 N  N   . LYS   A 1 354 ? -15.61206 48.39150 -6.93605  1.000 18.79407 ? 354 LYS   A N   1 
ATOM   2855 C  CA  . LYS   A 1 354 ? -15.97154 49.31745 -8.00645  1.000 20.83092 ? 354 LYS   A CA  1 
ATOM   2856 C  C   . LYS   A 1 354 ? -15.28385 49.03290 -9.33988  1.000 18.45939 ? 354 LYS   A C   1 
ATOM   2857 O  O   . LYS   A 1 354 ? -15.50890 49.77644 -10.29585 1.000 21.58024 ? 354 LYS   A O   1 
ATOM   2858 C  CB  . LYS   A 1 354 ? -15.67620 50.77052 -7.58293  1.000 19.86250 ? 354 LYS   A CB  1 
ATOM   2859 C  CG  . LYS   A 1 354 ? -16.26917 51.15065 -6.22654  1.000 26.44351 ? 354 LYS   A CG  1 
ATOM   2860 C  CD  . LYS   A 1 354 ? -17.77546 51.32354 -6.31625  1.000 30.47326 ? 354 LYS   A CD  1 
ATOM   2861 C  CE  . LYS   A 1 354 ? -18.23901 52.67711 -5.80325  1.000 44.45141 ? 354 LYS   A CE  1 
ATOM   2862 N  NZ  . LYS   A 1 354 ? -19.72188 52.84967 -5.94391  1.000 50.39554 ? 354 LYS   A NZ  1 
ATOM   2863 N  N   . GLY   A 1 355 ? -14.46893 47.98878 -9.44003  1.000 14.94978 ? 355 GLY   A N   1 
ATOM   2864 C  CA  . GLY   A 1 355 ? -13.77198 47.65860 -10.66285 1.000 16.40436 ? 355 GLY   A CA  1 
ATOM   2865 C  C   . GLY   A 1 355 ? -14.45618 46.56818 -11.46381 1.000 18.51608 ? 355 GLY   A C   1 
ATOM   2866 O  O   . GLY   A 1 355 ? -15.63708 46.25596 -11.26953 1.000 18.49947 ? 355 GLY   A O   1 
ATOM   2867 N  N   . LYS   A 1 356 ? -13.69605 45.97509 -12.38283 1.000 15.31387 ? 356 LYS   A N   1 
ATOM   2868 C  CA  . LYS   A 1 356 ? -14.24338 45.01731 -13.32964 1.000 15.83129 ? 356 LYS   A CA  1 
ATOM   2869 C  C   . LYS   A 1 356 ? -13.30351 43.83343 -13.43123 1.000 11.88367 ? 356 LYS   A C   1 
ATOM   2870 O  O   . LYS   A 1 356 ? -12.10408 44.00899 -13.65951 1.000 13.73444 ? 356 LYS   A O   1 
ATOM   2871 C  CB  . LYS   A 1 356 ? -14.44307 45.65659 -14.72076 1.000 15.42459 ? 356 LYS   A CB  1 
ATOM   2872 C  CG  . LYS   A 1 356 ? -15.30622 44.83636 -15.69062 1.000 15.82247 ? 356 LYS   A CG  1 
ATOM   2873 C  CD  . LYS   A 1 356 ? -16.80184 45.00289 -15.38387 1.000 15.83422 ? 356 LYS   A CD  1 
ATOM   2874 C  CE  . LYS   A 1 356 ? -17.65929 43.92506 -16.07259 1.000 14.58779 ? 356 LYS   A CE  1 
ATOM   2875 N  NZ  . LYS   A 1 356 ? -17.52829 42.58460 -15.41559 1.000 16.30860 ? 356 LYS   A NZ  1 
ATOM   2876 N  N   . ASP   A 1 357 ? -13.85132 42.63832 -13.24429 1.000 13.86763 ? 357 ASP   A N   1 
ATOM   2877 C  CA  . ASP   A 1 357 ? -13.18477 41.37930 -13.53464 1.000 11.63658 ? 357 ASP   A CA  1 
ATOM   2878 C  C   . ASP   A 1 357 ? -13.69430 40.83606 -14.86929 1.000 13.21956 ? 357 ASP   A C   1 
ATOM   2879 O  O   . ASP   A 1 357 ? -14.64183 41.35568 -15.46043 1.000 15.01651 ? 357 ASP   A O   1 
ATOM   2880 C  CB  . ASP   A 1 357 ? -13.42672 40.37856 -12.39853 1.000 13.84719 ? 357 ASP   A CB  1 
ATOM   2881 C  CG  . ASP   A 1 357 ? -12.24773 39.45037 -12.17178 1.000 14.69823 ? 357 ASP   A CG  1 
ATOM   2882 O  OD1 . ASP   A 1 357 ? -11.58191 39.07094 -13.16389 1.000 17.26057 ? 357 ASP   A OD1 1 
ATOM   2883 O  OD2 . ASP   A 1 357 ? -11.98427 39.10319 -11.00141 1.000 14.77819 ? 357 ASP   A OD2 1 
ATOM   2884 N  N   . ALA   A 1 358 ? -13.05700 39.77041 -15.35066 1.000 14.52161 ? 358 ALA   A N   1 
ATOM   2885 C  CA  . ALA   A 1 358 ? -13.31684 39.26092 -16.70166 1.000 13.51326 ? 358 ALA   A CA  1 
ATOM   2886 C  C   . ALA   A 1 358 ? -13.10060 37.75232 -16.73310 1.000 11.72327 ? 358 ALA   A C   1 
ATOM   2887 O  O   . ALA   A 1 358 ? -12.17685 37.25208 -17.39198 1.000 11.51376 ? 358 ALA   A O   1 
ATOM   2888 C  CB  . ALA   A 1 358 ? -12.40754 39.96426 -17.71249 1.000 12.00672 ? 358 ALA   A CB  1 
ATOM   2889 N  N   . PRO   A 1 359 ? -13.96351 36.98519 -16.05524 1.000 10.55568 ? 359 PRO   A N   1 
ATOM   2890 C  CA  . PRO   A 1 359 ? -13.61891 35.59477 -15.70813 1.000 9.83857  ? 359 PRO   A CA  1 
ATOM   2891 C  C   . PRO   A 1 359 ? -14.05261 34.49339 -16.65710 1.000 13.66091 ? 359 PRO   A C   1 
ATOM   2892 O  O   . PRO   A 1 359 ? -13.66634 33.33869 -16.41821 1.000 13.73431 ? 359 PRO   A O   1 
ATOM   2893 C  CB  . PRO   A 1 359 ? -14.34360 35.40263 -14.37401 1.000 9.84355  ? 359 PRO   A CB  1 
ATOM   2894 C  CG  . PRO   A 1 359 ? -15.59186 36.21034 -14.53698 1.000 10.99585 ? 359 PRO   A CG  1 
ATOM   2895 C  CD  . PRO   A 1 359 ? -15.19765 37.42565 -15.37331 1.000 12.07081 ? 359 PRO   A CD  1 
ATOM   2896 N  N   . PHE   A 1 360 ? -14.84326 34.77825 -17.69179 1.000 10.76031 ? 360 PHE   A N   1 
ATOM   2897 C  CA  . PHE   A 1 360 ? -15.44300 33.71992 -18.48866 1.000 10.85962 ? 360 PHE   A CA  1 
ATOM   2898 C  C   . PHE   A 1 360 ? -14.72691 33.57201 -19.84050 1.000 12.75718 ? 360 PHE   A C   1 
ATOM   2899 O  O   . PHE   A 1 360 ? -13.70288 34.20093 -20.10627 1.000 14.27690 ? 360 PHE   A O   1 
ATOM   2900 C  CB  . PHE   A 1 360 ? -16.93523 33.99719 -18.66144 1.000 10.96602 ? 360 PHE   A CB  1 
ATOM   2901 C  CG  . PHE   A 1 360 ? -17.68080 34.13237 -17.35813 1.000 11.76381 ? 360 PHE   A CG  1 
ATOM   2902 C  CD1 . PHE   A 1 360 ? -17.61444 33.13115 -16.39299 1.000 8.07245  ? 360 PHE   A CD1 1 
ATOM   2903 C  CD2 . PHE   A 1 360 ? -18.44611 35.26468 -17.09626 1.000 11.45161 ? 360 PHE   A CD2 1 
ATOM   2904 C  CE1 . PHE   A 1 360 ? -18.31591 33.25421 -15.17840 1.000 11.96782 ? 360 PHE   A CE1 1 
ATOM   2905 C  CE2 . PHE   A 1 360 ? -19.15496 35.39255 -15.89340 1.000 11.54628 ? 360 PHE   A CE2 1 
ATOM   2906 C  CZ  . PHE   A 1 360 ? -19.07915 34.38383 -14.93221 1.000 11.19489 ? 360 PHE   A CZ  1 
ATOM   2907 N  N   . VAL   A 1 361 ? -15.26297 32.69734 -20.70137 1.000 12.35595 ? 361 VAL   A N   1 
ATOM   2908 C  CA  . VAL   A 1 361 ? -14.76860 32.58894 -22.07493 1.000 14.06527 ? 361 VAL   A CA  1 
ATOM   2909 C  C   . VAL   A 1 361 ? -15.54904 33.46812 -23.04347 1.000 11.99992 ? 361 VAL   A C   1 
ATOM   2910 O  O   . VAL   A 1 361 ? -15.17532 33.55863 -24.22353 1.000 13.78464 ? 361 VAL   A O   1 
ATOM   2911 C  CB  . VAL   A 1 361 ? -14.78539 31.13131 -22.59468 1.000 11.94494 ? 361 VAL   A CB  1 
ATOM   2912 C  CG1 . VAL   A 1 361 ? -13.98390 30.20832 -21.65959 1.000 9.71960  ? 361 VAL   A CG1 1 
ATOM   2913 C  CG2 . VAL   A 1 361 ? -16.20499 30.63530 -22.77784 1.000 10.17514 ? 361 VAL   A CG2 1 
ATOM   2914 N  N   . PHE   A 1 362 ? -16.60456 34.13706 -22.58170 1.000 10.39770 ? 362 PHE   A N   1 
ATOM   2915 C  CA  . PHE   A 1 362 ? -17.41235 35.03189 -23.40498 1.000 14.00797 ? 362 PHE   A CA  1 
ATOM   2916 C  C   . PHE   A 1 362 ? -17.32387 36.45119 -22.85183 1.000 14.35701 ? 362 PHE   A C   1 
ATOM   2917 O  O   . PHE   A 1 362 ? -17.58878 36.67191 -21.66238 1.000 11.17605 ? 362 PHE   A O   1 
ATOM   2918 C  CB  . PHE   A 1 362 ? -18.87929 34.56875 -23.44278 1.000 10.02395 ? 362 PHE   A CB  1 
ATOM   2919 C  CG  . PHE   A 1 362 ? -19.06388 33.13038 -23.88251 1.000 12.93855 ? 362 PHE   A CG  1 
ATOM   2920 C  CD1 . PHE   A 1 362 ? -18.75824 32.73838 -25.17092 1.000 13.57466 ? 362 PHE   A CD1 1 
ATOM   2921 C  CD2 . PHE   A 1 362 ? -19.57332 32.17369 -23.00391 1.000 14.31843 ? 362 PHE   A CD2 1 
ATOM   2922 C  CE1 . PHE   A 1 362 ? -18.93012 31.39362 -25.58538 1.000 13.81970 ? 362 PHE   A CE1 1 
ATOM   2923 C  CE2 . PHE   A 1 362 ? -19.76618 30.84800 -23.41080 1.000 12.33233 ? 362 PHE   A CE2 1 
ATOM   2924 C  CZ  . PHE   A 1 362 ? -19.43374 30.46040 -24.71186 1.000 12.18576 ? 362 PHE   A CZ  1 
ATOM   2925 N  N   . GLY   A 1 363 ? -16.97038 37.40723 -23.72002 1.000 15.09200 ? 363 GLY   A N   1 
ATOM   2926 C  CA  . GLY   A 1 363 ? -16.83535 38.80434 -23.35003 1.000 11.55913 ? 363 GLY   A CA  1 
ATOM   2927 C  C   . GLY   A 1 363 ? -18.15682 39.50067 -23.05136 1.000 16.15743 ? 363 GLY   A C   1 
ATOM   2928 O  O   . GLY   A 1 363 ? -19.24024 38.95336 -23.28247 1.000 13.54842 ? 363 GLY   A O   1 
ATOM   2929 N  N   . PRO   A 1 364 ? -18.09277 40.73303 -22.52978 1.000 13.75159 ? 364 PRO   A N   1 
ATOM   2930 C  CA  . PRO   A 1 364 ? -19.32797 41.42721 -22.13052 1.000 11.29840 ? 364 PRO   A CA  1 
ATOM   2931 C  C   . PRO   A 1 364 ? -20.18395 41.86755 -23.29657 1.000 10.25506 ? 364 PRO   A C   1 
ATOM   2932 O  O   . PRO   A 1 364 ? -21.34436 42.22878 -23.07709 1.000 12.15080 ? 364 PRO   A O   1 
ATOM   2933 C  CB  . PRO   A 1 364 ? -18.81860 42.63610 -21.33146 1.000 14.08068 ? 364 PRO   A CB  1 
ATOM   2934 C  CG  . PRO   A 1 364 ? -17.44736 42.91280 -21.92416 1.000 15.45521 ? 364 PRO   A CG  1 
ATOM   2935 C  CD  . PRO   A 1 364 ? -16.89143 41.57673 -22.37251 1.000 16.28894 ? 364 PRO   A CD  1 
ATOM   2936 N  N   . ASP   A 1 365 ? -19.65910 41.87353 -24.51755 1.000 9.47076  ? 365 ASP   A N   1 
ATOM   2937 C  CA  . ASP   A 1 365 ? -20.47216 42.09710 -25.70057 1.000 10.86267 ? 365 ASP   A CA  1 
ATOM   2938 C  C   . ASP   A 1 365 ? -20.90087 40.78249 -26.33355 1.000 13.90739 ? 365 ASP   A C   1 
ATOM   2939 O  O   . ASP   A 1 365 ? -21.34294 40.77438 -27.48952 1.000 12.03120 ? 365 ASP   A O   1 
ATOM   2940 C  CB  . ASP   A 1 365 ? -19.71985 42.96395 -26.71886 1.000 13.70517 ? 365 ASP   A CB  1 
ATOM   2941 C  CG  . ASP   A 1 365 ? -18.31020 42.44447 -27.01938 1.000 13.74259 ? 365 ASP   A CG  1 
ATOM   2942 O  OD1 . ASP   A 1 365 ? -17.95581 41.35307 -26.51060 1.000 11.12219 ? 365 ASP   A OD1 1 
ATOM   2943 O  OD2 . ASP   A 1 365 ? -17.55709 43.12653 -27.76810 1.000 11.46342 ? 365 ASP   A OD2 1 
ATOM   2944 N  N   . TYR   A 1 366 ? -20.75276 39.66730 -25.60572 1.000 12.35195 ? 366 TYR   A N   1 
ATOM   2945 C  CA  . TYR   A 1 366 ? -21.19955 38.34830 -26.06114 1.000 13.44464 ? 366 TYR   A CA  1 
ATOM   2946 C  C   . TYR   A 1 366 ? -20.41008 37.86177 -27.26892 1.000 12.60842 ? 366 TYR   A C   1 
ATOM   2947 O  O   . TYR   A 1 366 ? -20.93363 37.13082 -28.11491 1.000 15.18376 ? 366 TYR   A O   1 
ATOM   2948 C  CB  . TYR   A 1 366 ? -22.70646 38.34410 -26.36236 1.000 12.09164 ? 366 TYR   A CB  1 
ATOM   2949 C  CG  . TYR   A 1 366 ? -23.54387 38.58045 -25.13015 1.000 13.79748 ? 366 TYR   A CG  1 
ATOM   2950 C  CD1 . TYR   A 1 366 ? -23.87402 39.86992 -24.72733 1.000 9.15400  ? 366 TYR   A CD1 1 
ATOM   2951 C  CD2 . TYR   A 1 366 ? -23.98122 37.51169 -24.34949 1.000 9.62333  ? 366 TYR   A CD2 1 
ATOM   2952 C  CE1 . TYR   A 1 366 ? -24.63669 40.09200 -23.58401 1.000 12.25970 ? 366 TYR   A CE1 1 
ATOM   2953 C  CE2 . TYR   A 1 366 ? -24.74114 37.72167 -23.20241 1.000 13.63574 ? 366 TYR   A CE2 1 
ATOM   2954 C  CZ  . TYR   A 1 366 ? -25.06894 39.01684 -22.82500 1.000 16.63335 ? 366 TYR   A CZ  1 
ATOM   2955 O  OH  . TYR   A 1 366 ? -25.81953 39.23594 -21.68681 1.000 16.13260 ? 366 TYR   A OH  1 
ATOM   2956 N  N   . LYS   A 1 367 ? -19.14317 38.25555 -27.35650 1.000 15.11432 ? 367 LYS   A N   1 
ATOM   2957 C  CA  . LYS   A 1 367 ? -18.22653 37.77281 -28.38168 1.000 11.95561 ? 367 LYS   A CA  1 
ATOM   2958 C  C   . LYS   A 1 367 ? -17.17116 36.90271 -27.71516 1.000 12.67330 ? 367 LYS   A C   1 
ATOM   2959 O  O   . LYS   A 1 367 ? -16.81380 37.13024 -26.55648 1.000 14.47690 ? 367 LYS   A O   1 
ATOM   2960 C  CB  . LYS   A 1 367 ? -17.56685 38.94155 -29.13047 1.000 12.33840 ? 367 LYS   A CB  1 
ATOM   2961 C  CG  . LYS   A 1 367 ? -18.53982 39.75875 -29.96437 1.000 12.30418 ? 367 LYS   A CG  1 
ATOM   2962 C  CD  . LYS   A 1 367 ? -17.91439 41.04040 -30.52722 1.000 14.97522 ? 367 LYS   A CD  1 
ATOM   2963 C  CE  . LYS   A 1 367 ? -18.97176 41.90093 -31.23845 1.000 18.13281 ? 367 LYS   A CE  1 
ATOM   2964 N  NZ  . LYS   A 1 367 ? -18.54435 43.32411 -31.45849 1.000 20.59988 ? 367 LYS   A NZ  1 
ATOM   2965 N  N   . VAL   A 1 368 ? -16.65656 35.91399 -28.45505 1.000 13.13386 ? 368 VAL   A N   1 
ATOM   2966 C  CA  . VAL   A 1 368 ? -15.78079 34.90861 -27.86271 1.000 11.34671 ? 368 VAL   A CA  1 
ATOM   2967 C  C   . VAL   A 1 368 ? -14.40772 35.51002 -27.57994 1.000 12.00228 ? 368 VAL   A C   1 
ATOM   2968 O  O   . VAL   A 1 368 ? -13.89052 36.34289 -28.33623 1.000 13.08183 ? 368 VAL   A O   1 
ATOM   2969 C  CB  . VAL   A 1 368 ? -15.68410 33.65164 -28.75460 1.000 13.65320 ? 368 VAL   A CB  1 
ATOM   2970 C  CG1 . VAL   A 1 368 ? -17.06530 32.98880 -28.90915 1.000 11.46931 ? 368 VAL   A CG1 1 
ATOM   2971 C  CG2 . VAL   A 1 368 ? -15.04754 33.96248 -30.14075 1.000 10.71666 ? 368 VAL   A CG2 1 
ATOM   2972 N  N   . LYS   A 1 369 ? -13.82422 35.09780 -26.47042 1.000 11.87100 ? 369 LYS   A N   1 
ATOM   2973 C  CA  . LYS   A 1 369 ? -12.51992 35.53547 -25.99497 1.000 15.14759 ? 369 LYS   A CA  1 
ATOM   2974 C  C   . LYS   A 1 369 ? -11.44999 34.55115 -26.43604 1.000 13.15111 ? 369 LYS   A C   1 
ATOM   2975 O  O   . LYS   A 1 369 ? -11.75180 33.46779 -26.94439 1.000 15.32082 ? 369 LYS   A O   1 
ATOM   2976 C  CB  . LYS   A 1 369 ? -12.53496 35.65462 -24.46573 1.000 10.08739 ? 369 LYS   A CB  1 
ATOM   2977 C  CG  . LYS   A 1 369 ? -13.51261 36.70090 -23.94616 1.000 9.60549  ? 369 LYS   A CG  1 
ATOM   2978 C  CD  . LYS   A 1 369 ? -13.76482 36.52616 -22.44764 1.000 11.54198 ? 369 LYS   A CD  1 
ATOM   2979 C  CE  . LYS   A 1 369 ? -12.52687 36.86864 -21.60883 1.000 12.49939 ? 369 LYS   A CE  1 
ATOM   2980 N  NZ  . LYS   A 1 369 ? -12.78371 36.71395 -20.14422 1.000 9.94148  ? 369 LYS   A NZ  1 
ATOM   2981 N  N   . PRO   A 1 370 ? -10.17599 34.89625 -26.27721 1.000 15.99875 ? 370 PRO   A N   1 
ATOM   2982 C  CA  . PRO   A 1 370 ? -9.13403  33.88053 -26.51526 1.000 12.15227 ? 370 PRO   A CA  1 
ATOM   2983 C  C   . PRO   A 1 370 ? -9.35091  32.61914 -25.68434 1.000 11.96330 ? 370 PRO   A C   1 
ATOM   2984 O  O   . PRO   A 1 370 ? -9.12217  31.50624 -26.17579 1.000 11.41065 ? 370 PRO   A O   1 
ATOM   2985 C  CB  . PRO   A 1 370 ? -7.83697  34.61456 -26.13350 1.000 13.11284 ? 370 PRO   A CB  1 
ATOM   2986 C  CG  . PRO   A 1 370 ? -8.14776  36.08680 -26.34525 1.000 15.44179 ? 370 PRO   A CG  1 
ATOM   2987 C  CD  . PRO   A 1 370 ? -9.61750  36.25235 -26.05262 1.000 14.06576 ? 370 PRO   A CD  1 
ATOM   2988 N  N   . ALA   A 1 371 ? -9.81106  32.76193 -24.43770 1.000 10.25442 ? 371 ALA   A N   1 
ATOM   2989 C  CA  . ALA   A 1 371 ? -10.06494 31.58692 -23.60680 1.000 11.40409 ? 371 ALA   A CA  1 
ATOM   2990 C  C   . ALA   A 1 371 ? -11.06053 30.62682 -24.25964 1.000 10.99628 ? 371 ALA   A C   1 
ATOM   2991 O  O   . ALA   A 1 371 ? -10.93001 29.40835 -24.11601 1.000 9.66832  ? 371 ALA   A O   1 
ATOM   2992 C  CB  . ALA   A 1 371 ? -10.56121 32.00982 -22.22360 1.000 9.99606  ? 371 ALA   A CB  1 
ATOM   2993 N  N   . TYR   A 1 372 ? -12.06854 31.14888 -24.96689 1.000 11.67059 ? 372 TYR   A N   1 
ATOM   2994 C  CA  . TYR   A 1 372 ? -12.99705 30.27080 -25.68456 1.000 10.58507 ? 372 TYR   A CA  1 
ATOM   2995 C  C   . TYR   A 1 372 ? -12.26343 29.39929 -26.70451 1.000 14.02609 ? 372 TYR   A C   1 
ATOM   2996 O  O   . TYR   A 1 372 ? -12.39371 28.16785 -26.69881 1.000 14.83565 ? 372 TYR   A O   1 
ATOM   2997 C  CB  . TYR   A 1 372 ? -14.09623 31.09192 -26.36802 1.000 9.44893  ? 372 TYR   A CB  1 
ATOM   2998 C  CG  . TYR   A 1 372 ? -14.89111 30.31320 -27.42024 1.000 12.20939 ? 372 TYR   A CG  1 
ATOM   2999 C  CD1 . TYR   A 1 372 ? -16.02661 29.58103 -27.07195 1.000 9.81653  ? 372 TYR   A CD1 1 
ATOM   3000 C  CD2 . TYR   A 1 372 ? -14.49499 30.30352 -28.75510 1.000 11.53847 ? 372 TYR   A CD2 1 
ATOM   3001 C  CE1 . TYR   A 1 372 ? -16.73920 28.86333 -28.02625 1.000 12.83457 ? 372 TYR   A CE1 1 
ATOM   3002 C  CE2 . TYR   A 1 372 ? -15.19133 29.59110 -29.70391 1.000 12.84850 ? 372 TYR   A CE2 1 
ATOM   3003 C  CZ  . TYR   A 1 372 ? -16.31521 28.87743 -29.34372 1.000 12.92060 ? 372 TYR   A CZ  1 
ATOM   3004 O  OH  . TYR   A 1 372 ? -17.00505 28.17380 -30.31001 1.000 13.71182 ? 372 TYR   A OH  1 
ATOM   3005 N  N   . TRP   A 1 373 ? -11.51953 30.02345 -27.62571 1.000 13.73276 ? 373 TRP   A N   1 
ATOM   3006 C  CA  . TRP   A 1 373 ? -10.78322 29.23681 -28.61711 1.000 13.75340 ? 373 TRP   A CA  1 
ATOM   3007 C  C   . TRP   A 1 373 ? -9.86617  28.23082 -27.93814 1.000 14.42215 ? 373 TRP   A C   1 
ATOM   3008 O  O   . TRP   A 1 373 ? -9.70065  27.10178 -28.41511 1.000 15.06332 ? 373 TRP   A O   1 
ATOM   3009 C  CB  . TRP   A 1 373 ? -9.98810  30.16016 -29.54586 1.000 16.48478 ? 373 TRP   A CB  1 
ATOM   3010 C  CG  . TRP   A 1 373 ? -10.87986 31.03387 -30.36659 1.000 16.69465 ? 373 TRP   A CG  1 
ATOM   3011 C  CD1 . TRP   A 1 373 ? -10.99558 32.39801 -30.29172 1.000 12.99984 ? 373 TRP   A CD1 1 
ATOM   3012 C  CD2 . TRP   A 1 373 ? -11.81303 30.60612 -31.36239 1.000 13.77752 ? 373 TRP   A CD2 1 
ATOM   3013 N  NE1 . TRP   A 1 373 ? -11.93271 32.83764 -31.18936 1.000 12.93246 ? 373 TRP   A NE1 1 
ATOM   3014 C  CE2 . TRP   A 1 373 ? -12.45483 31.75917 -31.85515 1.000 12.22621 ? 373 TRP   A CE2 1 
ATOM   3015 C  CE3 . TRP   A 1 373 ? -12.15929 29.35696 -31.89977 1.000 18.98679 ? 373 TRP   A CE3 1 
ATOM   3016 C  CZ2 . TRP   A 1 373 ? -13.42541 31.70625 -32.85613 1.000 14.65350 ? 373 TRP   A CZ2 1 
ATOM   3017 C  CZ3 . TRP   A 1 373 ? -13.12296 29.30502 -32.90709 1.000 15.93970 ? 373 TRP   A CZ3 1 
ATOM   3018 C  CH2 . TRP   A 1 373 ? -13.74682 30.47545 -33.36962 1.000 18.08138 ? 373 TRP   A CH2 1 
ATOM   3019 N  N   . ALA   A 1 374 ? -9.29344  28.61420 -26.79979 1.000 14.02784 ? 374 ALA   A N   1 
ATOM   3020 C  CA  . ALA   A 1 374 ? -8.41882  27.71807 -26.06067 1.000 17.04628 ? 374 ALA   A CA  1 
ATOM   3021 C  C   . ALA   A 1 374 ? -9.12859  26.44938 -25.58513 1.000 18.69659 ? 374 ALA   A C   1 
ATOM   3022 O  O   . ALA   A 1 374 ? -8.47172  25.42661 -25.38463 1.000 18.16921 ? 374 ALA   A O   1 
ATOM   3023 C  CB  . ALA   A 1 374 ? -7.81304  28.45085 -24.86354 1.000 14.65160 ? 374 ALA   A CB  1 
ATOM   3024 N  N   . ILE   A 1 375 ? -10.44153 26.47664 -25.36185 1.000 13.06024 ? 375 ILE   A N   1 
ATOM   3025 C  CA  . ILE   A 1 375 ? -11.11978 25.27533 -24.87679 1.000 12.42369 ? 375 ILE   A CA  1 
ATOM   3026 C  C   . ILE   A 1 375 ? -12.04992 24.64947 -25.90413 1.000 13.87549 ? 375 ILE   A C   1 
ATOM   3027 O  O   . ILE   A 1 375 ? -12.48984 23.50028 -25.69862 1.000 13.71811 ? 375 ILE   A O   1 
ATOM   3028 C  CB  . ILE   A 1 375 ? -11.87432 25.53164 -23.55223 1.000 13.33051 ? 375 ILE   A CB  1 
ATOM   3029 C  CG1 . ILE   A 1 375 ? -13.09916 26.42078 -23.75954 1.000 13.34366 ? 375 ILE   A CG1 1 
ATOM   3030 C  CG2 . ILE   A 1 375 ? -10.94208 26.10276 -22.48103 1.000 10.75488 ? 375 ILE   A CG2 1 
ATOM   3031 C  CD1 . ILE   A 1 375 ? -13.99859 26.46821 -22.53939 1.000 12.91747 ? 375 ILE   A CD1 1 
ATOM   3032 N  N   . ILE   A 1 376 ? -12.32955 25.32590 -27.02125 1.000 14.12415 ? 376 ILE   A N   1 
ATOM   3033 C  CA  . ILE   A 1 376 ? -13.17071 24.71113 -28.04575 1.000 12.49560 ? 376 ILE   A CA  1 
ATOM   3034 C  C   . ILE   A 1 376 ? -12.36404 23.79530 -28.95914 1.000 18.34307 ? 376 ILE   A C   1 
ATOM   3035 O  O   . ILE   A 1 376 ? -12.94814 22.92829 -29.62243 1.000 16.86349 ? 376 ILE   A O   1 
ATOM   3036 C  CB  . ILE   A 1 376 ? -13.91219 25.77275 -28.87985 1.000 12.51446 ? 376 ILE   A CB  1 
ATOM   3037 C  CG1 . ILE   A 1 376 ? -15.15940 25.18386 -29.54883 1.000 13.61283 ? 376 ILE   A CG1 1 
ATOM   3038 C  CG2 . ILE   A 1 376 ? -13.00410 26.35486 -29.96422 1.000 11.89661 ? 376 ILE   A CG2 1 
ATOM   3039 C  CD1 . ILE   A 1 376 ? -16.31850 24.90892 -28.59454 1.000 11.91517 ? 376 ILE   A CD1 1 
ATOM   3040 N  N   . ASP   A 1 377 ? -11.04091 23.95226 -29.00633 1.000 15.24326 ? 377 ASP   A N   1 
ATOM   3041 C  CA  . ASP   A 1 377 ? -10.20562 23.13865 -29.87740 1.000 16.10024 ? 377 ASP   A CA  1 
ATOM   3042 C  C   . ASP   A 1 377 ? -9.89674  21.79011 -29.22553 1.000 23.42972 ? 377 ASP   A C   1 
ATOM   3043 O  O   . ASP   A 1 377 ? -10.34781 21.47677 -28.11529 1.000 15.72738 ? 377 ASP   A O   1 
ATOM   3044 C  CB  . ASP   A 1 377 ? -8.91997  23.87860 -30.24795 1.000 16.78504 ? 377 ASP   A CB  1 
ATOM   3045 C  CG  . ASP   A 1 377 ? -7.93004  24.04649 -29.07347 1.000 22.58928 ? 377 ASP   A CG  1 
ATOM   3046 O  OD1 . ASP   A 1 377 ? -8.07590  23.47826 -27.94199 1.000 23.47327 ? 377 ASP   A OD1 1 
ATOM   3047 O  OD2 . ASP   A 1 377 ? -6.96049  24.80312 -29.31155 1.000 24.25179 ? 377 ASP   A OD2 1 
ATOM   3048 N  N   . HIS   A 1 378 ? -9.10690  20.97751 -29.92625 1.000 18.65110 ? 378 HIS   A N   1 
ATOM   3049 C  CA  . HIS   A 1 378 ? -8.72163  19.66902 -29.41640 1.000 23.73190 ? 378 HIS   A CA  1 
ATOM   3050 C  C   . HIS   A 1 378 ? -7.21475  19.57700 -29.23782 1.000 23.46645 ? 378 HIS   A C   1 
ATOM   3051 O  O   . HIS   A 1 378 ? -6.64419  18.49308 -29.32119 1.000 29.06461 ? 378 HIS   A O   1 
ATOM   3052 C  CB  . HIS   A 1 378 ? -9.23215  18.54988 -30.32512 1.000 20.45947 ? 378 HIS   A CB  1 
ATOM   3053 C  CG  . HIS   A 1 378 ? -10.71971 18.51519 -30.45106 1.000 21.53790 ? 378 HIS   A CG  1 
ATOM   3054 N  ND1 . HIS   A 1 378 ? -11.51394 17.70173 -29.67129 1.000 18.68756 ? 378 HIS   A ND1 1 
ATOM   3055 C  CD2 . HIS   A 1 378 ? -11.56248 19.21881 -31.24283 1.000 19.07226 ? 378 HIS   A CD2 1 
ATOM   3056 C  CE1 . HIS   A 1 378 ? -12.78187 17.88936 -29.99180 1.000 22.71832 ? 378 HIS   A CE1 1 
ATOM   3057 N  NE2 . HIS   A 1 378 ? -12.83836 18.80754 -30.94042 1.000 24.60180 ? 378 HIS   A NE2 1 
ATOM   3058 N  N   . LYS   A 1 379 ? -6.56732  20.71043 -28.99416 1.000 28.28380 ? 379 LYS   A N   1 
ATOM   3059 C  CA  . LYS   A 1 379 ? -5.13035  20.74869 -28.71507 1.000 30.95311 ? 379 LYS   A CA  1 
ATOM   3060 C  C   . LYS   A 1 379 ? -4.92526  21.10583 -27.26595 1.000 30.02805 ? 379 LYS   A C   1 
ATOM   3061 O  O   . LYS   A 1 379 ? -5.79785  21.71503 -26.66480 1.000 26.57427 ? 379 LYS   A O   1 
ATOM   3062 C  CB  . LYS   A 1 379 ? -4.40267  21.77468 -29.58717 1.000 29.18690 ? 379 LYS   A CB  1 
ATOM   3063 C  CG  . LYS   A 1 379 ? -4.70839  21.69561 -31.05909 1.000 38.27249 ? 379 LYS   A CG  1 
ATOM   3064 C  CD  . LYS   A 1 379 ? -3.82547  22.66107 -31.86099 1.000 52.43393 ? 379 LYS   A CD  1 
ATOM   3065 C  CE  . LYS   A 1 379 ? -3.97527  24.10917 -31.37471 1.000 57.91905 ? 379 LYS   A CE  1 
ATOM   3066 N  NZ  . LYS   A 1 379 ? -5.22302  24.77659 -31.86939 1.000 52.96470 ? 379 LYS   A NZ  1 
ATOM   3067 O  OXT . LYS   A 1 379 ? -3.89094  20.82179 -26.67193 1.000 42.17539 ? 379 LYS   A OXT 1 
HETATM 3068 C  C1  . A1ID6 B 2 .   ? -19.92828 30.78358 -3.98182  0.964 21.60860 ? 1   A1ID6 D C1  1 
HETATM 3069 C  C2  . A1ID6 B 2 .   ? -21.28422 30.60992 -3.30880  0.964 20.03088 ? 1   A1ID6 D C2  1 
HETATM 3070 C  C3  . A1ID6 B 2 .   ? -22.33652 31.29099 -4.17903  0.964 19.63169 ? 1   A1ID6 D C3  1 
HETATM 3071 C  C4  . A1ID6 B 2 .   ? -21.96811 32.76443 -4.28772  0.964 21.65895 ? 1   A1ID6 D C4  1 
HETATM 3072 C  C5  . A1ID6 B 2 .   ? -20.60881 32.85056 -4.99268  0.964 19.53062 ? 1   A1ID6 D C5  1 
HETATM 3073 O  O2  . A1ID6 B 2 .   ? -21.59484 29.22020 -3.19198  0.964 17.80497 ? 1   A1ID6 D O2  1 
HETATM 3074 O  O3  . A1ID6 B 2 .   ? -23.63150 31.15978 -3.59290  0.964 19.05959 ? 1   A1ID6 D O3  1 
HETATM 3075 O  O4  . A1ID6 B 2 .   ? -22.98222 33.46891 -5.00174  0.964 18.93448 ? 1   A1ID6 D O4  1 
HETATM 3076 O  O5  . A1ID6 B 2 .   ? -19.63111 32.16899 -4.18871  0.964 22.31856 ? 1   A1ID6 D O5  1 
HETATM 3077 F  F1  . A1ID6 B 2 .   ? -19.95137 30.12233 -5.19634  0.964 27.81818 ? 1   A1ID6 D F1  1 
HETATM 3078 C  C1  . XYP   B 2 .   ? -22.96520 34.86506 -4.76806  0.964 17.60255 ? 2   XYP   D C1  1 
HETATM 3079 C  C2  . XYP   B 2 .   ? -23.87435 35.50798 -5.80961  0.964 19.05173 ? 2   XYP   D C2  1 
HETATM 3080 C  C3  . XYP   B 2 .   ? -24.01765 36.99300 -5.54668  0.964 18.58306 ? 2   XYP   D C3  1 
HETATM 3081 C  C4  . XYP   B 2 .   ? -24.50934 37.18303 -4.11849  0.964 16.93555 ? 2   XYP   D C4  1 
HETATM 3082 C  C5  . XYP   B 2 .   ? -23.55259 36.50687 -3.13934  0.964 19.56178 ? 2   XYP   D C5  1 
HETATM 3083 O  O2  . XYP   B 2 .   ? -23.37083 35.34749 -7.14321  0.964 18.88320 ? 2   XYP   D O2  1 
HETATM 3084 O  O3  . XYP   B 2 .   ? -24.92175 37.51799 -6.53379  0.964 17.33274 ? 2   XYP   D O3  1 
HETATM 3085 O  O4  . XYP   B 2 .   ? -24.58820 38.57878 -3.82316  0.964 20.04840 ? 2   XYP   D O4  1 
HETATM 3086 O  O5  . XYP   B 2 .   ? -23.46350 35.11289 -3.44111  0.964 18.16424 ? 2   XYP   D O5  1 
HETATM 3087 C  C1  . A1ID6 C 3 .   ? -0.46073  32.70876 -5.31828  0.891 44.70748 ? 1   A1ID6 E C1  1 
HETATM 3088 C  C2  . A1ID6 C 3 .   ? -1.64256  33.66730 -5.51382  0.891 39.24343 ? 1   A1ID6 E C2  1 
HETATM 3089 C  C3  . A1ID6 C 3 .   ? -2.30239  33.99426 -4.17615  0.891 38.45126 ? 1   A1ID6 E C3  1 
HETATM 3090 C  C4  . A1ID6 C 3 .   ? -2.63407  32.72138 -3.40417  0.891 38.33461 ? 1   A1ID6 E C4  1 
HETATM 3091 C  C5  . A1ID6 C 3 .   ? -1.36438  31.89303 -3.24159  0.891 35.38568 ? 1   A1ID6 E C5  1 
HETATM 3092 O  O2  . A1ID6 C 3 .   ? -1.21533  34.88616 -6.14916  0.891 45.16961 ? 1   A1ID6 E O2  1 
HETATM 3093 O  O3  . A1ID6 C 3 .   ? -3.50320  34.74079 -4.38575  0.891 33.88011 ? 1   A1ID6 E O3  1 
HETATM 3094 O  O4  . A1ID6 C 3 .   ? -3.16678  33.04074 -2.11772  0.891 37.27395 ? 1   A1ID6 E O4  1 
HETATM 3095 O  O5  . A1ID6 C 3 .   ? -0.84457  31.57041 -4.53488  0.891 42.07199 ? 1   A1ID6 E O5  1 
HETATM 3096 F  F1  . A1ID6 C 3 .   ? 0.56466   33.34927 -4.67549  0.891 63.24385 ? 1   A1ID6 E F1  1 
HETATM 3097 C  C1  . XYP   C 3 .   ? -4.46082  32.47500 -1.92266  0.891 36.02121 ? 2   XYP   E C1  1 
HETATM 3098 C  C2  . XYP   C 3 .   ? -4.76122  32.35658 -0.43173  0.891 34.21604 ? 2   XYP   E C2  1 
HETATM 3099 C  C3  . XYP   C 3 .   ? -6.16631  31.80106 -0.22941  0.891 36.39394 ? 2   XYP   E C3  1 
HETATM 3100 C  C4  . XYP   C 3 .   ? -7.17269  32.67757 -0.95505  0.891 33.92846 ? 2   XYP   E C4  1 
HETATM 3101 C  C5  . XYP   C 3 .   ? -6.76350  32.76070 -2.42536  0.891 29.61846 ? 2   XYP   E C5  1 
HETATM 3102 O  O2  . XYP   C 3 .   ? -3.80691  31.47005 0.15644   0.891 43.28631 ? 2   XYP   E O2  1 
HETATM 3103 O  O3  . XYP   C 3 .   ? -6.51987  31.72085 1.15552   0.891 37.65889 ? 2   XYP   E O3  1 
HETATM 3104 O  O4  . XYP   C 3 .   ? -8.46351  32.08980 -0.77865  0.891 31.44233 ? 2   XYP   E O4  1 
HETATM 3105 O  O5  . XYP   C 3 .   ? -5.44544  33.28151 -2.57641  0.891 33.00403 ? 2   XYP   E O5  1 
HETATM 3106 C  C1  . XYP   C 3 .   ? -9.58556  32.97513 -0.82125  0.891 25.50704 ? 3   XYP   E C1  1 
HETATM 3107 C  C2  . XYP   C 3 .   ? -10.25611 32.79408 -2.18030  0.891 23.28260 ? 3   XYP   E C2  1 
HETATM 3108 C  C3  . XYP   C 3 .   ? -11.64588 33.38902 -2.21575  0.891 21.38039 ? 3   XYP   E C3  1 
HETATM 3109 C  C4  . XYP   C 3 .   ? -12.48932 32.87334 -1.06703  0.891 19.38244 ? 3   XYP   E C4  1 
HETATM 3110 C  C5  . XYP   C 3 .   ? -11.76212 33.18096 0.23558   0.891 20.63474 ? 3   XYP   E C5  1 
HETATM 3111 O  O2  . XYP   C 3 .   ? -9.51154  33.44727 -3.21195  0.891 24.42573 ? 3   XYP   E O2  1 
HETATM 3112 O  O3  . XYP   C 3 .   ? -12.24608 33.05987 -3.47144  0.891 20.84042 ? 3   XYP   E O3  1 
HETATM 3113 O  O4  . XYP   C 3 .   ? -13.72060 33.58693 -1.12202  0.891 21.22171 ? 3   XYP   E O4  1 
HETATM 3114 O  O5  . XYP   C 3 .   ? -10.47675 32.56204 0.21923   0.891 22.16327 ? 3   XYP   E O5  1 
HETATM 3115 C  C1  . XYP   C 3 .   ? -14.90513 32.81321 -0.96891  0.891 20.21390 ? 4   XYP   E C1  1 
HETATM 3116 C  C2  . XYP   C 3 .   ? -15.80888 33.61616 -0.04402  0.891 22.29849 ? 4   XYP   E C2  1 
HETATM 3117 C  C3  . XYP   C 3 .   ? -17.17595 32.96708 0.06863   0.891 25.18121 ? 4   XYP   E C3  1 
HETATM 3118 C  C4  . XYP   C 3 .   ? -17.75250 32.79672 -1.32217  0.891 22.38303 ? 4   XYP   E C4  1 
HETATM 3119 C  C5  . XYP   C 3 .   ? -16.79479 31.96400 -2.16996  0.891 20.99519 ? 4   XYP   E C5  1 
HETATM 3120 O  O2  . XYP   C 3 .   ? -15.21345 33.69688 1.25472   0.891 25.40695 ? 4   XYP   E O2  1 
HETATM 3121 O  O3  . XYP   C 3 .   ? -18.04594 33.80328 0.84111   0.891 27.21777 ? 4   XYP   E O3  1 
HETATM 3122 O  O4  . XYP   C 3 .   ? -19.02975 32.17796 -1.19447  0.891 21.63713 ? 4   XYP   E O4  1 
HETATM 3123 O  O5  . XYP   C 3 .   ? -15.53156 32.64157 -2.24126  0.891 22.43961 ? 4   XYP   E O5  1 
HETATM 3124 ZN ZN  . ZN    D 4 .   ? -25.11832 37.89749 -10.20124 1.000 19.24251 ? 401 ZN    A ZN  1 
HETATM 3125 ZN ZN  . ZN    E 4 .   ? -17.67894 12.66716 -17.17514 1.000 59.71887 ? 402 ZN    A ZN  1 
HETATM 3126 ZN ZN  . ZN    F 4 .   ? -7.18834  23.57630 -25.81311 1.000 37.10962 ? 403 ZN    A ZN  1 
HETATM 3127 ZN ZN  . ZN    G 4 .   ? -15.57130 42.83566 -27.76736 1.000 16.27537 ? 404 ZN    A ZN  1 
HETATM 3128 ZN ZN  . ZN    H 4 .   ? -16.05590 50.69256 -20.90222 1.000 51.74685 ? 405 ZN    A ZN  1 
HETATM 3129 ZN ZN  . ZN    I 4 .   ? -27.01332 22.09498 -26.39373 1.000 17.02514 ? 406 ZN    A ZN  1 
HETATM 3130 CL CL  . CL    J 5 .   ? -23.62071 38.92316 -8.99909  1.000 22.16388 ? 407 CL    A CL  1 
HETATM 3131 CL CL  . CL    K 5 .   ? -14.76777 43.07156 -25.74315 1.000 14.49223 ? 408 CL    A CL  1 
HETATM 3132 O  O   . HOH   L 6 .   ? -13.55920 47.03610 -23.58532 1.000 28.77875 ? 501 HOH   A O   1 
HETATM 3133 O  O   . HOH   L 6 .   ? -9.59901  58.85202 -6.95916  1.000 36.42581 ? 502 HOH   A O   1 
HETATM 3134 O  O   . HOH   L 6 .   ? -10.88307 16.22785 -28.08174 1.000 17.99648 ? 503 HOH   A O   1 
HETATM 3135 O  O   . HOH   L 6 .   ? -13.53142 53.06819 -21.33900 1.000 32.44101 ? 504 HOH   A O   1 
HETATM 3136 O  O   . HOH   L 6 .   ? -2.46183  43.66006 -15.52292 1.000 35.04521 ? 505 HOH   A O   1 
HETATM 3137 O  O   . HOH   L 6 .   ? -12.72087 52.99615 -8.88038  1.000 21.31828 ? 506 HOH   A O   1 
HETATM 3138 O  O   . HOH   L 6 .   ? -15.19724 10.29443 -19.39019 1.000 22.15146 ? 507 HOH   A O   1 
HETATM 3139 O  O   . HOH   L 6 .   ? -4.62331  11.67855 -12.84209 1.000 22.98990 ? 508 HOH   A O   1 
HETATM 3140 O  O   . HOH   L 6 .   ? -7.03023  49.34164 2.24686   1.000 32.93199 ? 509 HOH   A O   1 
HETATM 3141 O  O   . HOH   L 6 .   ? -5.68686  25.08920 -27.23907 1.000 24.32218 ? 510 HOH   A O   1 
HETATM 3142 O  O   . HOH   L 6 .   ? -23.28569 6.79348  2.52544   1.000 35.28030 ? 511 HOH   A O   1 
HETATM 3143 O  O   . HOH   L 6 .   ? -22.21108 27.16263 5.65812   1.000 19.43498 ? 512 HOH   A O   1 
HETATM 3144 O  O   . HOH   L 6 .   ? -35.22888 32.36374 25.93493  1.000 37.87842 ? 513 HOH   A O   1 
HETATM 3145 O  O   . HOH   L 6 .   ? -25.25177 17.63269 -15.41616 1.000 27.66967 ? 514 HOH   A O   1 
HETATM 3146 O  O   . HOH   L 6 .   ? 4.69004   42.63962 -6.69002  1.000 40.62998 ? 515 HOH   A O   1 
HETATM 3147 O  O   . HOH   L 6 .   ? 1.90673   52.76071 -6.30070  1.000 30.25030 ? 516 HOH   A O   1 
HETATM 3148 O  O   . HOH   L 6 .   ? -28.03078 9.91914  9.64565   1.000 40.12671 ? 517 HOH   A O   1 
HETATM 3149 O  O   . HOH   L 6 .   ? -24.95897 9.01061  11.95229  1.000 37.06184 ? 518 HOH   A O   1 
HETATM 3150 O  O   . HOH   L 6 .   ? 0.00836   18.34027 -1.78216  1.000 29.17138 ? 519 HOH   A O   1 
HETATM 3151 O  O   . HOH   L 6 .   ? -24.84290 23.23477 21.91380  1.000 43.86929 ? 520 HOH   A O   1 
HETATM 3152 O  O   . HOH   L 6 .   ? -20.32872 12.09517 13.76177  1.000 43.88642 ? 521 HOH   A O   1 
HETATM 3153 O  O   . HOH   L 6 .   ? -8.59986  43.96476 -2.42714  1.000 20.77179 ? 522 HOH   A O   1 
HETATM 3154 O  O   . HOH   L 6 .   ? -19.68342 45.42783 -13.11920 1.000 22.58961 ? 523 HOH   A O   1 
HETATM 3155 O  O   . HOH   L 6 .   ? -1.39289  47.74509 -15.91930 1.000 29.90279 ? 524 HOH   A O   1 
HETATM 3156 O  O   . HOH   L 6 .   ? -30.60242 22.84164 33.03519  1.000 44.17070 ? 525 HOH   A O   1 
HETATM 3157 O  O   . HOH   L 6 .   ? -26.83486 38.59905 -9.48024  1.000 17.25319 ? 526 HOH   A O   1 
HETATM 3158 O  O   . HOH   L 6 .   ? -11.58572 57.94587 -7.74696  1.000 33.07301 ? 527 HOH   A O   1 
HETATM 3159 O  O   . HOH   L 6 .   ? -28.70257 35.07245 8.46396   1.000 38.40014 ? 528 HOH   A O   1 
HETATM 3160 O  O   . HOH   L 6 .   ? -24.33791 12.11553 15.46508  1.000 39.24413 ? 529 HOH   A O   1 
HETATM 3161 O  O   . HOH   L 6 .   ? -5.73896  35.75616 -11.54035 1.000 14.33324 ? 530 HOH   A O   1 
HETATM 3162 O  O   . HOH   L 6 .   ? -34.04755 40.94457 -18.39540 1.000 34.74522 ? 531 HOH   A O   1 
HETATM 3163 O  O   . HOH   L 6 .   ? -23.42017 43.65657 -23.59619 1.000 28.72493 ? 532 HOH   A O   1 
HETATM 3164 O  O   . HOH   L 6 .   ? -14.44502 52.01304 -11.00409 1.000 27.88834 ? 533 HOH   A O   1 
HETATM 3165 O  O   . HOH   L 6 .   ? -45.63161 37.92530 7.48360   1.000 45.18983 ? 534 HOH   A O   1 
HETATM 3166 O  O   . HOH   L 6 .   ? -20.05047 23.54420 10.14115  1.000 19.64722 ? 535 HOH   A O   1 
HETATM 3167 O  O   . HOH   L 6 .   ? -26.60106 38.97728 -18.28562 1.000 18.75838 ? 536 HOH   A O   1 
HETATM 3168 O  O   . HOH   L 6 .   ? -0.70921  21.83973 -16.13641 1.000 35.28231 ? 537 HOH   A O   1 
HETATM 3169 O  O   . HOH   L 6 .   ? -9.15234  21.99876 -25.88018 1.000 16.56627 ? 538 HOH   A O   1 
HETATM 3170 O  O   . HOH   L 6 .   ? -22.58689 25.88485 8.24801   1.000 22.57409 ? 539 HOH   A O   1 
HETATM 3171 O  O   . HOH   L 6 .   ? -23.40301 36.28259 -16.04206 1.000 14.74661 ? 540 HOH   A O   1 
HETATM 3172 O  O   . HOH   L 6 .   ? -25.89526 23.26503 -27.78757 1.000 11.19107 ? 541 HOH   A O   1 
HETATM 3173 O  O   . HOH   L 6 .   ? -32.11366 37.35915 -7.90021  1.000 25.04965 ? 542 HOH   A O   1 
HETATM 3174 O  O   . HOH   L 6 .   ? -27.78713 41.07460 -22.01605 1.000 23.44670 ? 543 HOH   A O   1 
HETATM 3175 O  O   . HOH   L 6 .   ? -10.03173 45.10225 -22.23698 1.000 26.01573 ? 544 HOH   A O   1 
HETATM 3176 O  O   . HOH   L 6 .   ? -0.19936  14.90869 -13.10711 1.000 42.70276 ? 545 HOH   A O   1 
HETATM 3177 O  O   . HOH   L 6 .   ? -29.16404 26.82632 22.05493  1.000 32.04597 ? 546 HOH   A O   1 
HETATM 3178 O  O   . HOH   L 6 .   ? -44.56693 29.42428 -10.32374 1.000 20.14648 ? 547 HOH   A O   1 
HETATM 3179 O  O   . HOH   L 6 .   ? -42.95194 12.94246 0.58761   1.000 27.76724 ? 548 HOH   A O   1 
HETATM 3180 O  O   . HOH   L 6 .   ? -34.54694 19.19191 -17.74576 1.000 27.82554 ? 549 HOH   A O   1 
HETATM 3181 O  O   . HOH   L 6 .   ? -5.06791  49.96764 -17.80092 1.000 17.96348 ? 550 HOH   A O   1 
HETATM 3182 O  O   . HOH   L 6 .   ? -8.79607  9.70397  -14.49213 1.000 35.32773 ? 551 HOH   A O   1 
HETATM 3183 O  O   . HOH   L 6 .   ? -1.78462  37.29069 -15.47304 1.000 26.80636 ? 552 HOH   A O   1 
HETATM 3184 O  O   . HOH   L 6 .   ? -30.91232 16.65567 -19.31627 1.000 34.93440 ? 553 HOH   A O   1 
HETATM 3185 O  O   . HOH   L 6 .   ? -27.57582 23.90357 -25.53078 1.000 11.74320 ? 554 HOH   A O   1 
HETATM 3186 O  O   . HOH   L 6 .   ? -2.62190  32.07759 -24.61878 1.000 32.83971 ? 555 HOH   A O   1 
HETATM 3187 O  O   . HOH   L 6 .   ? -27.32107 19.78408 22.89788  1.000 32.76376 ? 556 HOH   A O   1 
HETATM 3188 O  O   . HOH   L 6 .   ? -14.95467 25.13917 14.48515  1.000 34.83773 ? 557 HOH   A O   1 
HETATM 3189 O  O   . HOH   L 6 .   ? -45.58743 14.58925 2.85496   1.000 11.90617 ? 558 HOH   A O   1 
HETATM 3190 O  O   . HOH   L 6 .   ? -0.17772  39.82343 -17.78525 1.000 33.44044 ? 559 HOH   A O   1 
HETATM 3191 O  O   . HOH   L 6 .   ? -35.84416 17.50892 16.19202  1.000 34.94370 ? 560 HOH   A O   1 
HETATM 3192 O  O   . HOH   L 6 .   ? -4.00857  43.16270 -9.82436  1.000 19.68584 ? 561 HOH   A O   1 
HETATM 3193 O  O   . HOH   L 6 .   ? -18.55158 45.00949 -29.32274 1.000 16.49108 ? 562 HOH   A O   1 
HETATM 3194 O  O   . HOH   L 6 .   ? -27.21176 20.42209 25.69925  1.000 40.64141 ? 563 HOH   A O   1 
HETATM 3195 O  O   . HOH   L 6 .   ? -20.16190 31.25268 -18.96354 1.000 12.02144 ? 564 HOH   A O   1 
HETATM 3196 O  O   . HOH   L 6 .   ? -29.61863 30.02313 -5.63305  1.000 9.81350  ? 565 HOH   A O   1 
HETATM 3197 O  O   . HOH   L 6 .   ? -40.24989 31.62169 12.91160  1.000 19.23938 ? 566 HOH   A O   1 
HETATM 3198 O  O   . HOH   L 6 .   ? -6.98795  18.79544 7.63251   1.000 35.69038 ? 567 HOH   A O   1 
HETATM 3199 O  O   . HOH   L 6 .   ? -14.82293 44.20706 -1.93664  1.000 23.70394 ? 568 HOH   A O   1 
HETATM 3200 O  O   . HOH   L 6 .   ? -18.97087 22.15594 2.41261   1.000 18.40140 ? 569 HOH   A O   1 
HETATM 3201 O  O   . HOH   L 6 .   ? -40.68535 25.82161 14.16233  1.000 23.47473 ? 570 HOH   A O   1 
HETATM 3202 O  O   . HOH   L 6 .   ? -0.83313  24.95328 -12.65746 1.000 30.65132 ? 571 HOH   A O   1 
HETATM 3203 O  O   . HOH   L 6 .   ? -13.993   22.250   -31.983   1.000 29.50075 ? 572 HOH   A O   1 
HETATM 3204 O  O   . HOH   L 6 .   ? -38.36653 35.47169 -1.58645  1.000 28.64155 ? 573 HOH   A O   1 
HETATM 3205 O  O   . HOH   L 6 .   ? -43.65485 21.32928 -1.84949  1.000 15.84339 ? 574 HOH   A O   1 
HETATM 3206 O  O   . HOH   L 6 .   ? -30.78712 33.19638 -9.11794  1.000 12.13818 ? 575 HOH   A O   1 
HETATM 3207 O  O   . HOH   L 6 .   ? -33.57818 29.24372 24.42888  1.000 27.03860 ? 576 HOH   A O   1 
HETATM 3208 O  O   . HOH   L 6 .   ? -18.57349 34.60295 -11.71595 1.000 15.82027 ? 577 HOH   A O   1 
HETATM 3209 O  O   . HOH   L 6 .   ? -3.57754  20.17746 -18.10694 1.000 16.57213 ? 578 HOH   A O   1 
HETATM 3210 O  O   . HOH   L 6 .   ? -6.57570  48.31564 -8.01023  1.000 15.52974 ? 579 HOH   A O   1 
HETATM 3211 O  O   . HOH   L 6 .   ? -12.55523 40.24981 -8.63244  1.000 14.81786 ? 580 HOH   A O   1 
HETATM 3212 O  O   . HOH   L 6 .   ? -35.75880 36.76226 0.81135   1.000 27.96049 ? 581 HOH   A O   1 
HETATM 3213 O  O   . HOH   L 6 .   ? -30.33086 26.21260 -8.21449  1.000 13.02303 ? 582 HOH   A O   1 
HETATM 3214 O  O   . HOH   L 6 .   ? -2.96889  22.34180 -2.30237  1.000 33.22112 ? 583 HOH   A O   1 
HETATM 3215 O  O   . HOH   L 6 .   ? -2.93540  24.49163 -26.62824 1.000 34.62372 ? 584 HOH   A O   1 
HETATM 3216 O  O   . HOH   L 6 .   ? -16.18760 26.88779 3.60936   1.000 14.12803 ? 585 HOH   A O   1 
HETATM 3217 O  O   . HOH   L 6 .   ? -33.97618 38.34738 13.63415  1.000 35.00477 ? 586 HOH   A O   1 
HETATM 3218 O  O   . HOH   L 6 .   ? -28.25994 24.26160 21.25465  1.000 26.31857 ? 587 HOH   A O   1 
HETATM 3219 O  O   . HOH   L 6 .   ? -42.06575 25.80082 7.33233   1.000 15.78181 ? 588 HOH   A O   1 
HETATM 3220 O  O   . HOH   L 6 .   ? -16.57574 49.37494 -13.83941 1.000 28.06252 ? 589 HOH   A O   1 
HETATM 3221 O  O   . HOH   L 6 .   ? -3.494    45.442   -0.281    1.000 40.95573 ? 590 HOH   A O   1 
HETATM 3222 O  O   . HOH   L 6 .   ? -43.16783 33.25725 9.95829   1.000 24.70099 ? 591 HOH   A O   1 
HETATM 3223 O  O   . HOH   L 6 .   ? -37.66939 31.27451 -5.66146  1.000 12.40854 ? 592 HOH   A O   1 
HETATM 3224 O  O   . HOH   L 6 .   ? -23.96803 35.56810 0.36725   1.000 25.11172 ? 593 HOH   A O   1 
HETATM 3225 O  O   . HOH   L 6 .   ? -30.97384 41.53498 -28.60222 1.000 44.41375 ? 594 HOH   A O   1 
HETATM 3226 O  O   . HOH   L 6 .   ? -38.13132 36.57954 8.57468   1.000 27.85786 ? 595 HOH   A O   1 
HETATM 3227 O  O   . HOH   L 6 .   ? -11.47434 22.89950 -10.19351 1.000 17.88374 ? 596 HOH   A O   1 
HETATM 3228 O  O   . HOH   L 6 .   ? -41.25373 22.63561 11.05194  1.000 16.70987 ? 597 HOH   A O   1 
HETATM 3229 O  O   . HOH   L 6 .   ? -13.84647 26.54225 11.16814  1.000 23.56333 ? 598 HOH   A O   1 
HETATM 3230 O  O   . HOH   L 6 .   ? -15.62535 37.39681 -1.39882  1.000 22.91980 ? 599 HOH   A O   1 
HETATM 3231 O  O   . HOH   L 6 .   ? -26.58893 12.77337 18.17347  1.000 34.18756 ? 600 HOH   A O   1 
HETATM 3232 O  O   . HOH   L 6 .   ? -2.00203  16.22961 -16.15759 1.000 30.53694 ? 601 HOH   A O   1 
HETATM 3233 O  O   . HOH   L 6 .   ? -38.58894 25.16390 7.88782   1.000 14.98016 ? 602 HOH   A O   1 
HETATM 3234 O  O   . HOH   L 6 .   ? -21.80187 35.82728 -10.98152 1.000 12.65316 ? 603 HOH   A O   1 
HETATM 3235 O  O   . HOH   L 6 .   ? -38.56493 31.23313 17.24571  1.000 19.36979 ? 604 HOH   A O   1 
HETATM 3236 O  O   . HOH   L 6 .   ? -29.02731 32.06816 17.33709  1.000 25.95108 ? 605 HOH   A O   1 
HETATM 3237 O  O   . HOH   L 6 .   ? -21.68066 18.90003 -22.34450 1.000 11.50759 ? 606 HOH   A O   1 
HETATM 3238 O  O   . HOH   L 6 .   ? -28.52451 14.99074 20.31994  1.000 34.68298 ? 607 HOH   A O   1 
HETATM 3239 O  O   . HOH   L 6 .   ? -32.76117 9.20112  4.58246   1.000 24.04771 ? 608 HOH   A O   1 
HETATM 3240 O  O   . HOH   L 6 .   ? -27.31685 7.64526  -5.02861  1.000 36.41931 ? 609 HOH   A O   1 
HETATM 3241 O  O   . HOH   L 6 .   ? -37.57903 21.57597 20.82653  1.000 35.71433 ? 610 HOH   A O   1 
HETATM 3242 O  O   . HOH   L 6 .   ? -44.79595 19.51027 0.00000   0.50  8.50060  ? 611 HOH   A O   1 
HETATM 3243 O  O   . HOH   L 6 .   ? -19.00331 25.24804 18.61021  1.000 40.19029 ? 612 HOH   A O   1 
HETATM 3244 O  O   . HOH   L 6 .   ? -28.30439 42.52510 -19.85988 1.000 36.74226 ? 613 HOH   A O   1 
HETATM 3245 O  O   . HOH   L 6 .   ? -24.65382 16.97939 16.47969  1.000 24.18830 ? 614 HOH   A O   1 
HETATM 3246 O  O   . HOH   L 6 .   ? -23.26341 25.54417 -6.91030  1.000 16.02180 ? 615 HOH   A O   1 
HETATM 3247 O  O   . HOH   L 6 .   ? -40.90781 17.25349 -8.77698  1.000 21.16488 ? 616 HOH   A O   1 
HETATM 3248 O  O   . HOH   L 6 .   ? -19.82249 45.84032 -6.35015  1.000 33.45995 ? 617 HOH   A O   1 
HETATM 3249 O  O   . HOH   L 6 .   ? -11.32900 53.01227 -18.87921 1.000 26.45661 ? 618 HOH   A O   1 
HETATM 3250 O  O   . HOH   L 6 .   ? -26.10010 35.02099 -34.92657 1.000 41.31443 ? 619 HOH   A O   1 
HETATM 3251 O  O   . HOH   L 6 .   ? -17.91598 46.81369 -9.82016  1.000 20.78824 ? 620 HOH   A O   1 
HETATM 3252 O  O   . HOH   L 6 .   ? -19.31379 32.53545 2.39215   1.000 25.93894 ? 621 HOH   A O   1 
HETATM 3253 O  O   . HOH   L 6 .   ? -9.11366  8.54317  -7.95768  1.000 30.02603 ? 622 HOH   A O   1 
HETATM 3254 O  O   . HOH   L 6 .   ? -44.30634 19.84560 5.38112   1.000 14.10954 ? 623 HOH   A O   1 
HETATM 3255 O  O   . HOH   L 6 .   ? -39.01200 30.70077 -17.36294 1.000 23.04859 ? 624 HOH   A O   1 
HETATM 3256 O  O   . HOH   L 6 .   ? -0.20835  26.90857 -20.98327 1.000 26.27551 ? 625 HOH   A O   1 
HETATM 3257 O  O   . HOH   L 6 .   ? -15.43550 10.24381 -9.49403  1.000 23.44480 ? 626 HOH   A O   1 
HETATM 3258 O  O   . HOH   L 6 .   ? -6.91955  15.76224 -21.80899 1.000 19.11902 ? 627 HOH   A O   1 
HETATM 3259 O  O   . HOH   L 6 .   ? -1.58616  18.08367 -13.68131 1.000 35.53419 ? 628 HOH   A O   1 
HETATM 3260 O  O   . HOH   L 6 .   ? -23.67403 15.28746 -21.72132 1.000 25.74692 ? 629 HOH   A O   1 
HETATM 3261 O  O   . HOH   L 6 .   ? -11.83615 30.32561 -3.98024  1.000 20.37596 ? 630 HOH   A O   1 
HETATM 3262 O  O   . HOH   L 6 .   ? -1.44749  15.92830 -9.64563  1.000 33.27063 ? 631 HOH   A O   1 
HETATM 3263 O  O   . HOH   L 6 .   ? -18.99008 22.31707 -30.80695 1.000 14.29324 ? 632 HOH   A O   1 
HETATM 3264 O  O   . HOH   L 6 .   ? -32.31526 17.91545 -13.55608 1.000 16.05835 ? 633 HOH   A O   1 
HETATM 3265 O  O   . HOH   L 6 .   ? -12.91859 24.53160 -5.35058  1.000 14.01913 ? 634 HOH   A O   1 
HETATM 3266 O  O   . HOH   L 6 .   ? -24.85079 36.98401 -33.48802 1.000 35.14185 ? 635 HOH   A O   1 
HETATM 3267 O  O   . HOH   L 6 .   ? 1.81052   22.55884 -7.37618  1.000 21.51819 ? 636 HOH   A O   1 
HETATM 3268 O  O   . HOH   L 6 .   ? -21.23671 8.79642  -6.62915  1.000 31.16291 ? 637 HOH   A O   1 
HETATM 3269 O  O   . HOH   L 6 .   ? -38.22413 32.03877 14.55323  1.000 23.37621 ? 638 HOH   A O   1 
HETATM 3270 O  O   . HOH   L 6 .   ? -7.80929  22.54542 -23.50717 1.000 14.44417 ? 639 HOH   A O   1 
HETATM 3271 O  O   . HOH   L 6 .   ? -4.63817  27.19685 4.32712   1.000 36.61601 ? 640 HOH   A O   1 
HETATM 3272 O  O   . HOH   L 6 .   ? -18.57529 39.53377 -2.42646  1.000 32.15759 ? 641 HOH   A O   1 
HETATM 3273 O  O   . HOH   L 6 .   ? -35.94099 18.10399 -15.49973 1.000 26.62023 ? 642 HOH   A O   1 
HETATM 3274 O  O   . HOH   L 6 .   ? -45.052   22.218   -4.090    1.000 15.18425 ? 643 HOH   A O   1 
HETATM 3275 O  O   . HOH   L 6 .   ? -7.49948  25.64288 4.05299   1.000 25.84616 ? 644 HOH   A O   1 
HETATM 3276 O  O   . HOH   L 6 .   ? -18.50056 11.04934 -12.82697 1.000 21.96416 ? 645 HOH   A O   1 
HETATM 3277 O  O   . HOH   L 6 .   ? -26.00619 8.15247  -1.52054  1.000 29.41607 ? 646 HOH   A O   1 
HETATM 3278 O  O   . HOH   L 6 .   ? -9.58711  32.89146 -6.06371  1.000 19.11397 ? 647 HOH   A O   1 
HETATM 3279 O  O   . HOH   L 6 .   ? -4.93556  12.31545 -4.95971  1.000 25.11586 ? 648 HOH   A O   1 
HETATM 3280 O  O   . HOH   L 6 .   ? -24.65677 21.19269 -34.07695 1.000 29.17055 ? 649 HOH   A O   1 
HETATM 3281 O  O   . HOH   L 6 .   ? -42.04573 21.52291 -10.65899 1.000 32.18494 ? 650 HOH   A O   1 
HETATM 3282 O  O   . HOH   L 6 .   ? -15.51638 28.74902 11.84716  1.000 26.33918 ? 651 HOH   A O   1 
HETATM 3283 O  O   . HOH   L 6 .   ? -29.74297 22.30141 -23.20540 1.000 17.79211 ? 652 HOH   A O   1 
HETATM 3284 O  O   . HOH   L 6 .   ? -14.40873 51.65001 -0.69857  1.000 32.89826 ? 653 HOH   A O   1 
HETATM 3285 O  O   . HOH   L 6 .   ? -43.04568 16.19501 -7.06861  1.000 25.66695 ? 654 HOH   A O   1 
HETATM 3286 O  O   . HOH   L 6 .   ? -12.07337 55.34494 -1.33380  1.000 35.42715 ? 655 HOH   A O   1 
HETATM 3287 O  O   . HOH   L 6 .   ? -30.14923 25.15584 -23.40218 1.000 12.23180 ? 656 HOH   A O   1 
HETATM 3288 O  O   . HOH   L 6 .   ? -2.77147  35.69618 -1.65611  1.000 38.13280 ? 657 HOH   A O   1 
HETATM 3289 O  O   . HOH   L 6 .   ? -9.42834  37.29666 -7.55147  1.000 18.87806 ? 658 HOH   A O   1 
HETATM 3290 O  O   . HOH   L 6 .   ? -11.22553 36.83405 -29.15993 1.000 15.25031 ? 659 HOH   A O   1 
HETATM 3291 O  O   . HOH   L 6 .   ? -11.27294 34.87501 -7.19328  1.000 18.04177 ? 660 HOH   A O   1 
HETATM 3292 O  O   . HOH   L 6 .   ? -23.60976 24.94071 -9.48664  1.000 15.06240 ? 661 HOH   A O   1 
HETATM 3293 O  O   . HOH   L 6 .   ? -2.60782  33.53866 -9.63648  1.000 29.05270 ? 662 HOH   A O   1 
HETATM 3294 O  O   . HOH   L 6 .   ? -13.00725 16.84007 9.30676   1.000 33.44036 ? 663 HOH   A O   1 
HETATM 3295 O  O   . HOH   L 6 .   ? -25.35732 23.85329 -13.83083 1.000 15.02795 ? 664 HOH   A O   1 
HETATM 3296 O  O   . HOH   L 6 .   ? -35.58147 35.91499 9.73286   1.000 25.46765 ? 665 HOH   A O   1 
HETATM 3297 O  O   . HOH   L 6 .   ? -12.86687 26.95716 14.20955  1.000 32.67462 ? 666 HOH   A O   1 
HETATM 3298 O  O   . HOH   L 6 .   ? -40.79435 25.03272 9.82745   1.000 19.77141 ? 667 HOH   A O   1 
HETATM 3299 O  O   . HOH   L 6 .   ? -21.02285 21.21169 -32.32397 1.000 18.57167 ? 668 HOH   A O   1 
HETATM 3300 O  O   . HOH   L 6 .   ? -9.28060  35.01113 -22.39105 1.000 11.01755 ? 669 HOH   A O   1 
HETATM 3301 O  O   . HOH   L 6 .   ? -21.26444 42.11833 -12.73108 1.000 16.09152 ? 670 HOH   A O   1 
HETATM 3302 O  O   . HOH   L 6 .   ? -39.00822 33.60535 -17.07308 1.000 21.55895 ? 671 HOH   A O   1 
HETATM 3303 O  O   . HOH   L 6 .   ? -12.50717 27.41018 -4.94850  1.000 11.64948 ? 672 HOH   A O   1 
HETATM 3304 O  O   . HOH   L 6 .   ? -17.32299 15.26126 -25.94017 1.000 15.89381 ? 673 HOH   A O   1 
HETATM 3305 O  O   . HOH   L 6 .   ? -26.41678 20.28547 -27.39308 1.000 12.11678 ? 674 HOH   A O   1 
HETATM 3306 O  O   . HOH   L 6 .   ? -9.90274  20.91722 -23.58764 1.000 14.55261 ? 675 HOH   A O   1 
HETATM 3307 O  O   . HOH   L 6 .   ? -27.22399 25.12214 -31.35429 1.000 22.97102 ? 676 HOH   A O   1 
HETATM 3308 O  O   . HOH   L 6 .   ? -30.82759 34.44236 14.21251  1.000 39.42911 ? 677 HOH   A O   1 
HETATM 3309 O  O   . HOH   L 6 .   ? -35.41484 36.73121 5.93171   1.000 25.26237 ? 678 HOH   A O   1 
HETATM 3310 O  O   . HOH   L 6 .   ? -6.80126  11.64945 5.94590   1.000 45.83849 ? 679 HOH   A O   1 
HETATM 3311 O  O   . HOH   L 6 .   ? -32.79767 26.54032 0.18145   1.000 11.07563 ? 680 HOH   A O   1 
HETATM 3312 O  O   . HOH   L 6 .   ? -1.45264  27.86743 -13.54409 1.000 28.95222 ? 681 HOH   A O   1 
HETATM 3313 O  O   . HOH   L 6 .   ? -31.80760 16.15635 -15.61434 1.000 27.25030 ? 682 HOH   A O   1 
HETATM 3314 O  O   . HOH   L 6 .   ? -4.68676  41.40043 -7.82455  1.000 20.03845 ? 683 HOH   A O   1 
HETATM 3315 O  O   . HOH   L 6 .   ? -9.88377  27.48212 -5.20441  1.000 17.31285 ? 684 HOH   A O   1 
HETATM 3316 O  O   . HOH   L 6 .   ? -29.32125 30.18813 -29.47872 1.000 28.68823 ? 685 HOH   A O   1 
HETATM 3317 O  O   . HOH   L 6 .   ? -19.644   38.146   -35.207   1.000 29.75296 ? 686 HOH   A O   1 
HETATM 3318 O  O   . HOH   L 6 .   ? -6.45013  20.44254 16.63368  1.000 55.01135 ? 687 HOH   A O   1 
HETATM 3319 O  O   . HOH   L 6 .   ? -41.71393 13.09313 -1.50585  1.000 25.72319 ? 688 HOH   A O   1 
HETATM 3320 O  O   . HOH   L 6 .   ? -7.76317  9.88023  -19.23931 1.000 32.37415 ? 689 HOH   A O   1 
HETATM 3321 O  O   . HOH   L 6 .   ? -23.40819 14.45852 -16.73079 1.000 26.86718 ? 690 HOH   A O   1 
HETATM 3322 O  O   . HOH   L 6 .   ? -17.67653 10.91178 -19.28289 1.000 19.27078 ? 691 HOH   A O   1 
HETATM 3323 O  O   . HOH   L 6 .   ? -17.30093 30.90884 -19.64591 1.000 11.72904 ? 692 HOH   A O   1 
HETATM 3324 O  O   . HOH   L 6 .   ? -20.26006 9.90699  -22.40882 1.000 22.45724 ? 693 HOH   A O   1 
HETATM 3325 O  O   . HOH   L 6 .   ? -12.29844 33.52775 -9.17337  1.000 13.77162 ? 694 HOH   A O   1 
HETATM 3326 O  O   . HOH   L 6 .   ? -11.03223 21.34912 -7.95671  1.000 24.98374 ? 695 HOH   A O   1 
HETATM 3327 O  O   . HOH   L 6 .   ? -21.07685 22.86811 18.61654  1.000 34.16622 ? 696 HOH   A O   1 
HETATM 3328 O  O   . HOH   L 6 .   ? -36.38194 18.39192 -20.33244 1.000 38.40820 ? 697 HOH   A O   1 
HETATM 3329 O  O   . HOH   L 6 .   ? 2.53891   36.90878 -19.33435 1.000 32.13525 ? 698 HOH   A O   1 
HETATM 3330 O  O   . HOH   L 6 .   ? -2.43361  23.55579 0.46591   1.000 33.57279 ? 699 HOH   A O   1 
HETATM 3331 O  O   . HOH   L 6 .   ? -3.96093  43.63870 -2.33256  1.000 24.63405 ? 700 HOH   A O   1 
HETATM 3332 O  O   . HOH   L 6 .   ? -25.27879 35.06868 -14.13000 1.000 15.41429 ? 701 HOH   A O   1 
HETATM 3333 O  O   . HOH   L 6 .   ? -1.65679  25.40436 -5.65319  1.000 21.12937 ? 702 HOH   A O   1 
HETATM 3334 O  O   . HOH   L 6 .   ? -1.25716  31.39582 -17.69363 1.000 19.25419 ? 703 HOH   A O   1 
HETATM 3335 O  O   . HOH   L 6 .   ? -13.69610 40.24946 -24.41682 1.000 15.87299 ? 704 HOH   A O   1 
HETATM 3336 O  O   . HOH   L 6 .   ? -11.91936 42.57159 -0.40944  1.000 29.92197 ? 705 HOH   A O   1 
HETATM 3337 O  O   . HOH   L 6 .   ? -41.12111 23.82286 -19.47275 1.000 23.50745 ? 706 HOH   A O   1 
HETATM 3338 O  O   . HOH   L 6 .   ? -18.65978 31.51082 9.25427   1.000 22.66272 ? 707 HOH   A O   1 
HETATM 3339 O  O   . HOH   L 6 .   ? -20.88902 17.78485 16.82786  1.000 31.87995 ? 708 HOH   A O   1 
HETATM 3340 O  O   . HOH   L 6 .   ? 4.67536   48.96044 -9.03122  1.000 42.85363 ? 709 HOH   A O   1 
HETATM 3341 O  O   . HOH   L 6 .   ? -1.25362  43.87005 -23.04382 1.000 24.58194 ? 710 HOH   A O   1 
HETATM 3342 O  O   . HOH   L 6 .   ? -42.79124 12.91892 7.21140   1.000 36.25309 ? 711 HOH   A O   1 
HETATM 3343 O  O   . HOH   L 6 .   ? -13.88016 43.75222 2.03687   1.000 44.19025 ? 712 HOH   A O   1 
HETATM 3344 O  O   . HOH   L 6 .   ? -28.09619 28.47860 -31.49532 1.000 35.66166 ? 713 HOH   A O   1 
HETATM 3345 O  O   . HOH   L 6 .   ? 2.27410   19.77350 -5.96801  1.000 38.11928 ? 714 HOH   A O   1 
HETATM 3346 O  O   . HOH   L 6 .   ? -16.46035 6.65066  -14.93163 1.000 29.02480 ? 715 HOH   A O   1 
HETATM 3347 O  O   . HOH   L 6 .   ? -4.94146  55.11326 -13.73929 1.000 32.92079 ? 716 HOH   A O   1 
HETATM 3348 O  O   . HOH   L 6 .   ? -43.16203 31.20951 -11.91053 1.000 20.50912 ? 717 HOH   A O   1 
HETATM 3349 O  O   . HOH   L 6 .   ? -8.78441  27.43153 2.38691   1.000 20.93988 ? 718 HOH   A O   1 
HETATM 3350 O  O   . HOH   L 6 .   ? -25.40906 32.01638 9.87603   1.000 29.15673 ? 719 HOH   A O   1 
HETATM 3351 O  O   . HOH   L 6 .   ? -18.41843 33.63508 5.23697   1.000 27.77177 ? 720 HOH   A O   1 
HETATM 3352 O  O   . HOH   L 6 .   ? -38.59578 37.08017 -13.10626 1.000 37.17703 ? 721 HOH   A O   1 
HETATM 3353 O  O   . HOH   L 6 .   ? -31.38471 26.36434 5.25812   1.000 22.64013 ? 722 HOH   A O   1 
HETATM 3354 O  O   . HOH   L 6 .   ? -26.31569 36.99906 3.82979   1.000 28.67927 ? 723 HOH   A O   1 
HETATM 3355 O  O   . HOH   L 6 .   ? -24.24953 37.51862 -18.91752 1.000 14.51507 ? 724 HOH   A O   1 
HETATM 3356 O  O   . HOH   L 6 .   ? -18.92991 44.94042 -2.82157  1.000 37.40289 ? 725 HOH   A O   1 
HETATM 3357 O  O   . HOH   L 6 .   ? -21.32745 27.10806 -5.91319  1.000 20.48123 ? 726 HOH   A O   1 
HETATM 3358 O  O   . HOH   L 6 .   ? -41.61512 25.33444 -13.28365 1.000 25.45863 ? 727 HOH   A O   1 
HETATM 3359 O  O   . HOH   L 6 .   ? -9.20801  27.33029 -31.37763 1.000 32.73324 ? 728 HOH   A O   1 
HETATM 3360 O  O   . HOH   L 6 .   ? -35.95635 7.45004  -0.54683  1.000 31.19360 ? 729 HOH   A O   1 
HETATM 3361 O  O   . HOH   L 6 .   ? -0.84655  11.14495 -14.97179 1.000 46.21099 ? 730 HOH   A O   1 
HETATM 3362 O  O   . HOH   L 6 .   ? -40.52515 33.54605 -5.44538  1.000 35.97609 ? 731 HOH   A O   1 
HETATM 3363 O  O   . HOH   L 6 .   ? -6.11200  48.47898 -21.93785 1.000 28.03112 ? 732 HOH   A O   1 
HETATM 3364 O  O   . HOH   L 6 .   ? 0.71945   56.61508 -3.15742  1.000 30.32489 ? 733 HOH   A O   1 
HETATM 3365 O  O   . HOH   L 6 .   ? -28.95512 6.41490  -0.01447  1.000 23.10985 ? 734 HOH   A O   1 
HETATM 3366 O  O   . HOH   L 6 .   ? -33.14854 14.00947 8.68694   1.000 36.76415 ? 735 HOH   A O   1 
HETATM 3367 O  O   . HOH   L 6 .   ? -33.36364 38.47180 19.57521  1.000 33.44443 ? 736 HOH   A O   1 
HETATM 3368 O  O   . HOH   L 6 .   ? -37.87908 35.17627 -15.46068 1.000 31.79268 ? 737 HOH   A O   1 
HETATM 3369 O  O   . HOH   L 6 .   ? -16.24384 32.71739 3.64531   1.000 39.11502 ? 738 HOH   A O   1 
HETATM 3370 O  O   . HOH   L 6 .   ? -10.72389 55.20726 -12.52250 1.000 27.83232 ? 739 HOH   A O   1 
HETATM 3371 O  O   . HOH   L 6 .   ? -15.03030 7.62522  -8.62607  1.000 41.75629 ? 740 HOH   A O   1 
HETATM 3372 O  O   . HOH   L 6 .   ? -41.59110 28.31919 15.32904  1.000 25.44813 ? 741 HOH   A O   1 
HETATM 3373 O  O   . HOH   L 6 .   ? -14.60514 31.97569 6.10548   1.000 30.28798 ? 742 HOH   A O   1 
HETATM 3374 O  O   . HOH   L 6 .   ? -8.09806  21.14087 -32.79952 1.000 20.81764 ? 743 HOH   A O   1 
HETATM 3375 O  O   . HOH   L 6 .   ? -14.24016 20.39001 13.78902  1.000 26.95265 ? 744 HOH   A O   1 
HETATM 3376 O  O   . HOH   L 6 .   ? -33.37720 37.17138 8.00562   1.000 19.03593 ? 745 HOH   A O   1 
HETATM 3377 O  O   . HOH   L 6 .   ? -37.99850 8.75037  8.70909   1.000 47.44343 ? 746 HOH   A O   1 
HETATM 3378 O  O   . HOH   L 6 .   ? -2.28798  38.26918 -4.68755  1.000 36.16526 ? 747 HOH   A O   1 
HETATM 3379 O  O   . HOH   L 6 .   ? -12.66415 10.09703 8.77445   1.000 37.91299 ? 748 HOH   A O   1 
HETATM 3380 O  O   . HOH   L 6 .   ? -22.09002 33.21828 18.64926  1.000 42.31281 ? 749 HOH   A O   1 
HETATM 3381 O  O   . HOH   L 6 .   ? -25.31439 23.72441 -35.47432 1.000 35.26560 ? 750 HOH   A O   1 
HETATM 3382 O  O   . HOH   L 6 .   ? -8.60050  18.66676 9.83990   1.000 39.04146 ? 751 HOH   A O   1 
HETATM 3383 O  O   . HOH   L 6 .   ? -16.50252 47.93444 -17.42762 1.000 19.85149 ? 752 HOH   A O   1 
HETATM 3384 O  O   . HOH   L 6 .   ? -13.44730 29.59963 7.86646   1.000 25.59352 ? 753 HOH   A O   1 
HETATM 3385 O  O   . HOH   L 6 .   ? -36.31670 11.46033 -8.41465  1.000 34.96016 ? 754 HOH   A O   1 
HETATM 3386 O  O   . HOH   L 6 .   ? -11.97756 38.11814 -6.85053  1.000 15.63798 ? 755 HOH   A O   1 
HETATM 3387 O  O   . HOH   L 6 .   ? -34.10700 5.74990  -0.39876  1.000 37.99770 ? 756 HOH   A O   1 
HETATM 3388 O  O   . HOH   L 6 .   ? -34.01468 38.46539 -11.46383 1.000 25.09798 ? 757 HOH   A O   1 
HETATM 3389 O  O   . HOH   L 6 .   ? -40.61076 33.47026 10.95353  1.000 17.79607 ? 758 HOH   A O   1 
HETATM 3390 O  O   . HOH   L 6 .   ? -27.36216 22.12253 -32.62948 1.000 33.60531 ? 759 HOH   A O   1 
HETATM 3391 O  O   . HOH   L 6 .   ? -44.76636 32.98564 -12.51551 1.000 37.93074 ? 760 HOH   A O   1 
HETATM 3392 O  O   . HOH   L 6 .   ? 0.14971   53.77988 -10.24470 1.000 37.49464 ? 761 HOH   A O   1 
HETATM 3393 O  O   . HOH   L 6 .   ? 0.61571   49.15537 -10.37123 1.000 23.47402 ? 762 HOH   A O   1 
HETATM 3394 O  O   . HOH   L 6 .   ? -28.31681 20.94334 -25.00147 1.000 12.93509 ? 763 HOH   A O   1 
HETATM 3395 O  O   . HOH   L 6 .   ? -3.23192  37.06615 -12.16018 1.000 20.00917 ? 764 HOH   A O   1 
HETATM 3396 O  O   . HOH   L 6 .   ? 0.836     22.106   -11.885   1.000 22.67865 ? 765 HOH   A O   1 
HETATM 3397 O  O   . HOH   L 6 .   ? -3.34174  12.19456 -7.54985  1.000 33.65797 ? 766 HOH   A O   1 
HETATM 3398 O  O   . HOH   L 6 .   ? -3.17208  40.94831 -5.60522  1.000 29.46827 ? 767 HOH   A O   1 
HETATM 3399 O  O   . HOH   L 6 .   ? -33.76765 41.64479 -24.86613 1.000 37.82437 ? 768 HOH   A O   1 
HETATM 3400 O  O   . HOH   L 6 .   ? -9.61806  53.57867 1.44490   1.000 31.20820 ? 769 HOH   A O   1 
HETATM 3401 O  O   . HOH   L 6 .   ? -21.94053 23.69579 20.94278  1.000 39.72111 ? 770 HOH   A O   1 
HETATM 3402 O  O   . HOH   L 6 .   ? -41.71105 23.97058 -10.99151 1.000 30.37384 ? 771 HOH   A O   1 
HETATM 3403 O  O   . HOH   L 6 .   ? -28.34753 24.36512 -29.57354 1.000 27.45910 ? 772 HOH   A O   1 
HETATM 3404 O  O   . HOH   L 6 .   ? -27.99018 35.81322 5.81727   1.000 28.96645 ? 773 HOH   A O   1 
HETATM 3405 O  O   . HOH   L 6 .   ? -2.78487  51.81764 -14.05191 1.000 36.20217 ? 774 HOH   A O   1 
HETATM 3406 O  O   . HOH   L 6 .   ? -19.02966 29.04654 19.87701  1.000 38.70829 ? 775 HOH   A O   1 
HETATM 3407 O  O   . HOH   L 6 .   ? -3.55754  46.31434 -24.16743 1.000 23.36130 ? 776 HOH   A O   1 
HETATM 3408 O  O   . HOH   L 6 .   ? -30.40389 41.47497 -25.40076 1.000 30.02276 ? 777 HOH   A O   1 
HETATM 3409 O  O   . HOH   L 6 .   ? -34.75170 14.45647 -11.12480 1.000 27.31881 ? 778 HOH   A O   1 
HETATM 3410 O  O   . HOH   L 6 .   ? -15.68964 48.47135 -19.85721 1.000 28.76139 ? 779 HOH   A O   1 
HETATM 3411 O  O   . HOH   L 6 .   ? -30.50139 37.26029 -0.72517  1.000 33.22185 ? 780 HOH   A O   1 
HETATM 3412 O  O   . HOH   L 6 .   ? -23.64212 28.59111 20.77503  1.000 36.25610 ? 781 HOH   A O   1 
HETATM 3413 O  O   . HOH   L 6 .   ? -37.40635 28.63764 -23.74220 1.000 17.30106 ? 782 HOH   A O   1 
HETATM 3414 O  O   . HOH   L 6 .   ? -21.01664 41.87930 -8.36589  1.000 26.18616 ? 783 HOH   A O   1 
HETATM 3415 O  O   . HOH   L 6 .   ? -25.34922 21.07564 20.59070  1.000 35.97490 ? 784 HOH   A O   1 
HETATM 3416 O  O   . HOH   L 6 .   ? -11.538   39.844   -34.632   1.000 19.79595 ? 785 HOH   A O   1 
HETATM 3417 O  O   . HOH   L 6 .   ? -37.13431 31.13631 -24.34188 1.000 25.91162 ? 786 HOH   A O   1 
HETATM 3418 O  O   . HOH   L 6 .   ? -18.78719 49.74110 -10.00906 1.000 41.57978 ? 787 HOH   A O   1 
HETATM 3419 O  O   . HOH   L 6 .   ? 1.29081   35.41205 -24.79427 1.000 32.82867 ? 788 HOH   A O   1 
HETATM 3420 O  O   . HOH   L 6 .   ? -21.61005 44.49259 -31.08568 1.000 22.55044 ? 789 HOH   A O   1 
HETATM 3421 O  O   . HOH   L 6 .   ? -18.02818 47.97314 -12.78840 1.000 38.03006 ? 790 HOH   A O   1 
HETATM 3422 O  O   . HOH   L 6 .   ? -2.09297  26.61893 -1.64701  1.000 31.42893 ? 791 HOH   A O   1 
HETATM 3423 O  O   . HOH   L 6 .   ? -20.31158 12.81740 -17.58183 1.000 18.71292 ? 792 HOH   A O   1 
HETATM 3424 O  O   . HOH   L 6 .   ? -22.43903 41.91514 -10.76433 1.000 30.95935 ? 793 HOH   A O   1 
HETATM 3425 O  O   . HOH   L 6 .   ? -25.05447 18.86295 19.55304  1.000 36.06910 ? 794 HOH   A O   1 
HETATM 3426 O  O   . HOH   L 6 .   ? -27.11096 18.29868 -24.51958 1.000 31.89106 ? 795 HOH   A O   1 
HETATM 3427 O  O   . HOH   L 6 .   ? -25.92349 29.62758 10.00872  1.000 29.68294 ? 796 HOH   A O   1 
HETATM 3428 O  O   . HOH   L 6 .   ? -23.15055 43.65475 -13.57553 1.000 34.03423 ? 797 HOH   A O   1 
HETATM 3429 O  O   . HOH   L 6 .   ? -25.39286 42.91271 -15.24205 1.000 37.53451 ? 798 HOH   A O   1 
HETATM 3430 O  O   . HOH   L 6 .   ? -12.76004 30.20168 -37.47840 1.000 46.42649 ? 799 HOH   A O   1 
HETATM 3431 O  O   . HOH   L 6 .   ? -10.18319 14.59171 -29.57302 1.000 21.43493 ? 800 HOH   A O   1 
HETATM 3432 O  O   . HOH   L 6 .   ? -30.90739 22.94182 -26.32581 1.000 30.72671 ? 801 HOH   A O   1 
HETATM 3433 O  O   . HOH   L 6 .   ? -21.37077 8.91837  -27.76919 1.000 33.13366 ? 802 HOH   A O   1 
HETATM 3434 O  O   . HOH   L 6 .   ? -32.02033 30.98345 30.29673  1.000 48.35000 ? 803 HOH   A O   1 
HETATM 3435 O  O   . HOH   L 6 .   ? -2.02340  35.02837 -11.45941 1.000 30.75512 ? 804 HOH   A O   1 
HETATM 3436 O  O   . HOH   L 6 .   ? -4.02247  17.59434 -17.89831 1.000 22.53877 ? 805 HOH   A O   1 
HETATM 3437 O  O   . HOH   L 6 .   ? -18.70176 11.09074 -15.35170 1.000 19.08974 ? 806 HOH   A O   1 
HETATM 3438 O  O   . HOH   L 6 .   ? -6.05406  9.73511  -5.11184  1.000 31.07994 ? 807 HOH   A O   1 
HETATM 3439 O  O   . HOH   L 6 .   ? -3.25674  42.00272 -12.47795 1.000 31.69099 ? 808 HOH   A O   1 
HETATM 3440 O  O   . HOH   L 6 .   ? -10.45243 39.05849 -28.35843 1.000 24.59087 ? 809 HOH   A O   1 
HETATM 3441 O  O   . HOH   L 6 .   ? -13.646   15.424   -31.297   1.000 25.69864 ? 810 HOH   A O   1 
HETATM 3442 O  O   . HOH   L 6 .   ? -40.96638 21.60173 -21.06007 1.000 27.98606 ? 811 HOH   A O   1 
HETATM 3443 O  O   . HOH   L 6 .   ? 0.82892   30.75929 -19.51807 1.000 32.55958 ? 812 HOH   A O   1 
HETATM 3444 O  O   . HOH   L 6 .   ? -34.93322 12.48668 7.41996   1.000 33.11094 ? 813 HOH   A O   1 
HETATM 3445 O  O   . HOH   L 6 .   ? -33.57992 32.49308 -28.41477 1.000 34.21090 ? 814 HOH   A O   1 
HETATM 3446 O  O   . HOH   L 6 .   ? -38.72600 17.50481 -18.96246 1.000 44.12098 ? 815 HOH   A O   1 
HETATM 3447 O  O   . HOH   L 6 .   ? -36.55168 12.30553 11.66441  1.000 40.57236 ? 816 HOH   A O   1 
HETATM 3448 O  O   . HOH   L 6 .   ? -35.65106 36.92297 12.45154  1.000 29.96012 ? 817 HOH   A O   1 
HETATM 3449 O  O   . HOH   L 6 .   ? -47.294   37.378   -11.054   1.000 37.89523 ? 818 HOH   A O   1 
HETATM 3450 O  O   . HOH   L 6 .   ? -23.15822 33.20778 10.19412  1.000 39.07142 ? 819 HOH   A O   1 
HETATM 3451 O  O   . HOH   L 6 .   ? -38.56780 20.16936 18.49054  1.000 35.87316 ? 820 HOH   A O   1 
HETATM 3452 O  O   . HOH   L 6 .   ? -24.74045 18.38433 -26.10434 1.000 21.76997 ? 821 HOH   A O   1 
HETATM 3453 O  O   . HOH   L 6 .   ? -28.41542 17.10169 -20.72843 1.000 32.88882 ? 822 HOH   A O   1 
HETATM 3454 O  O   . HOH   L 6 .   ? -14.77624 15.14845 10.80238  1.000 39.16472 ? 823 HOH   A O   1 
HETATM 3455 O  O   . HOH   L 6 .   ? -34.61819 14.52836 -13.42451 1.000 29.94507 ? 824 HOH   A O   1 
HETATM 3456 O  O   . HOH   L 6 .   ? -20.89226 44.36376 -8.48093  1.000 29.31588 ? 825 HOH   A O   1 
HETATM 3457 O  O   . HOH   L 6 .   ? 2.618     22.552   -9.588    1.000 31.47182 ? 826 HOH   A O   1 
HETATM 3458 O  O   . HOH   L 6 .   ? 0.61274   19.92897 -13.51009 1.000 38.73163 ? 827 HOH   A O   1 
HETATM 3459 O  O   . HOH   L 6 .   ? -2.70705  39.43782 -10.61968 1.000 29.26278 ? 828 HOH   A O   1 
HETATM 3460 O  O   . HOH   L 6 .   ? -6.07258  9.99212  -14.44277 1.000 37.16582 ? 829 HOH   A O   1 
HETATM 3461 O  O   . HOH   L 6 .   ? -1.12305  42.38050 -18.63124 1.000 26.50812 ? 830 HOH   A O   1 
HETATM 3462 O  O   . HOH   L 6 .   ? -11.78480 29.71657 9.66314   1.000 34.61244 ? 831 HOH   A O   1 
HETATM 3463 O  O   . HOH   L 6 .   ? -7.90596  30.48154 2.82588   1.000 42.41713 ? 832 HOH   A O   1 
HETATM 3464 O  O   . HOH   L 6 .   ? -28.80930 22.28723 -27.61859 1.000 11.60947 ? 833 HOH   A O   1 
HETATM 3465 O  O   . HOH   L 6 .   ? -20.57175 20.07872 18.45318  1.000 38.94060 ? 834 HOH   A O   1 
HETATM 3466 O  O   . HOH   L 6 .   ? -42.69005 29.56980 -14.17596 1.000 28.04920 ? 835 HOH   A O   1 
HETATM 3467 O  O   . HOH   L 6 .   ? -33.59701 12.65193 -11.33391 1.000 36.14478 ? 836 HOH   A O   1 
HETATM 3468 O  O   . HOH   L 6 .   ? -22.45185 40.85067 -6.24442  1.000 32.37969 ? 837 HOH   A O   1 
HETATM 3469 O  O   . HOH   L 6 .   ? -18.732   8.279    -27.642   1.000 17.05064 ? 838 HOH   A O   1 
HETATM 3470 O  O   . HOH   L 6 .   ? -35.82636 36.37275 -24.82686 1.000 31.47699 ? 839 HOH   A O   1 
HETATM 3471 O  O   . HOH   L 6 .   ? -20.13934 8.12880  -8.87239  1.000 31.32629 ? 840 HOH   A O   1 
HETATM 3472 O  O   . HOH   L 6 .   ? -13.38377 41.52287 -1.61702  1.000 29.53468 ? 841 HOH   A O   1 
HETATM 3473 O  O   . HOH   L 6 .   ? -21.17416 10.24672 -13.13255 1.000 40.22146 ? 842 HOH   A O   1 
HETATM 3474 O  O   . HOH   L 6 .   ? -38.26720 17.66607 17.85421  1.000 41.22590 ? 843 HOH   A O   1 
HETATM 3475 O  O   . HOH   L 6 .   ? -33.12530 16.22080 -19.96677 1.000 35.80371 ? 844 HOH   A O   1 
HETATM 3476 O  O   . HOH   L 6 .   ? -27.23767 15.13185 -20.11910 1.000 35.82210 ? 845 HOH   A O   1 
HETATM 3477 O  O   . HOH   L 6 .   ? -27.04053 40.18810 -6.80871  1.000 36.33670 ? 846 HOH   A O   1 
HETATM 3478 O  O   . HOH   L 6 .   ? -26.99254 39.22157 -4.03356  1.000 38.41364 ? 847 HOH   A O   1 
HETATM 3479 O  O   . HOH   L 6 .   ? -28.76917 12.34630 12.54985  1.000 38.75854 ? 848 HOH   A O   1 
HETATM 3480 O  O   . HOH   L 6 .   ? -8.964    14.363   -24.401   1.000 24.62114 ? 849 HOH   A O   1 
HETATM 3481 O  O   . HOH   L 6 .   ? -3.81445  18.36521 7.24243   1.000 44.79729 ? 850 HOH   A O   1 
HETATM 3482 O  O   . HOH   L 6 .   ? -34.67096 9.70817  7.14134   1.000 37.21375 ? 851 HOH   A O   1 
HETATM 3483 O  O   . HOH   L 6 .   ? -39.11241 28.44178 -21.12870 1.000 31.06681 ? 852 HOH   A O   1 
HETATM 3484 O  O   . HOH   L 6 .   ? 0.54405   40.34323 -15.07732 1.000 36.02822 ? 853 HOH   A O   1 
HETATM 3485 O  O   . HOH   L 6 .   ? -5.80211  10.31241 0.15208   1.000 40.72537 ? 854 HOH   A O   1 
HETATM 3486 O  O   . HOH   L 6 .   ? -41.01529 19.17003 -20.21753 1.000 42.23118 ? 855 HOH   A O   1 
HETATM 3487 O  O   . HOH   L 6 .   ? -35.55340 35.96098 -4.94010  1.000 26.72431 ? 856 HOH   A O   1 
HETATM 3488 O  O   . HOH   L 6 .   ? -31.67585 31.55123 -29.63572 1.000 30.72486 ? 857 HOH   A O   1 
HETATM 3489 O  O   . HOH   L 6 .   ? -20.49595 46.20831 -10.70549 1.000 33.54592 ? 858 HOH   A O   1 
HETATM 3490 O  O   . HOH   L 6 .   ? -7.73099  10.84714 -21.43817 1.000 28.37273 ? 859 HOH   A O   1 
HETATM 3491 O  O   . HOH   L 6 .   ? -2.33852  49.47396 -17.84629 1.000 28.98047 ? 860 HOH   A O   1 
HETATM 3492 O  O   . HOH   L 6 .   ? -43.76571 27.10274 -13.94926 1.000 33.89779 ? 861 HOH   A O   1 
HETATM 3493 O  O   . HOH   L 6 .   ? -16.36944 45.17370 0.43633   1.000 47.43489 ? 862 HOH   A O   1 
HETATM 3494 O  O   . HOH   L 6 .   ? -1.31363  49.99520 -14.42063 1.000 39.01124 ? 863 HOH   A O   1 
HETATM 3495 O  O   . HOH   L 6 .   ? -1.77568  19.73872 -15.73648 1.000 31.81593 ? 864 HOH   A O   1 
HETATM 3496 O  O   . HOH   L 6 .   ? -38.75914 27.42800 -25.47903 1.000 35.06195 ? 865 HOH   A O   1 
HETATM 3497 O  O   . HOH   L 6 .   ? -41.83241 22.96660 -14.74157 1.000 27.49227 ? 866 HOH   A O   1 
HETATM 3498 O  O   . HOH   L 6 .   ? -12.76222 6.39993  -10.18510 1.000 39.91030 ? 867 HOH   A O   1 
HETATM 3499 O  O   . HOH   L 6 .   ? -8.44234  51.03679 3.02750   1.000 37.93131 ? 868 HOH   A O   1 
HETATM 3500 O  O   . HOH   L 6 .   ? 2.53969   56.42694 -4.32971  1.000 36.43085 ? 869 HOH   A O   1 
HETATM 3501 O  O   . HOH   L 6 .   ? -21.17710 31.90502 10.40506  1.000 26.40712 ? 870 HOH   A O   1 
HETATM 3502 O  O   . HOH   L 6 .   ? -11.12448 25.66595 -33.10695 1.000 24.33880 ? 871 HOH   A O   1 
HETATM 3503 O  O   . HOH   L 6 .   ? -3.43172  12.68245 -2.56965  1.000 40.71890 ? 872 HOH   A O   1 
HETATM 3504 O  O   . HOH   L 6 .   ? -44.40500 12.71210 4.86874   1.000 28.86633 ? 873 HOH   A O   1 
HETATM 3505 O  O   . HOH   L 6 .   ? -26.924   17.444   -31.204   1.000 28.38604 ? 874 HOH   A O   1 
HETATM 3506 O  O   . HOH   L 6 .   ? -15.52247 4.74273  -14.36409 1.000 33.78188 ? 875 HOH   A O   1 
HETATM 3507 O  O   . HOH   L 6 .   ? -38.82868 30.63453 -19.93446 1.000 20.83102 ? 876 HOH   A O   1 
HETATM 3508 O  O   . HOH   L 6 .   ? 0.44286   21.99042 -18.49657 1.000 33.72699 ? 877 HOH   A O   1 
HETATM 3509 O  O   . HOH   L 6 .   ? -16.51404 29.22825 -36.32930 1.000 31.53819 ? 878 HOH   A O   1 
HETATM 3510 O  O   . HOH   L 6 .   ? -41.65276 23.19861 -23.98960 1.000 46.06377 ? 879 HOH   A O   1 
HETATM 3511 O  O   . HOH   L 6 .   ? -15.16015 16.25312 12.91026  1.000 46.50920 ? 880 HOH   A O   1 
HETATM 3512 O  O   . HOH   L 6 .   ? -5.68945  51.24804 -15.48616 1.000 26.56794 ? 881 HOH   A O   1 
HETATM 3513 O  O   . HOH   L 6 .   ? 0.42428   33.08679 -16.40244 1.000 37.32780 ? 882 HOH   A O   1 
HETATM 3514 O  O   . HOH   L 6 .   ? -38.19402 36.27258 12.85844  1.000 26.07169 ? 883 HOH   A O   1 
HETATM 3515 O  O   . HOH   L 6 .   ? -42.62739 23.27597 -17.07299 1.000 30.10180 ? 884 HOH   A O   1 
HETATM 3516 O  O   . HOH   L 6 .   ? -39.75022 35.84419 10.71393  1.000 24.70512 ? 885 HOH   A O   1 
HETATM 3517 O  O   . HOH   L 6 .   ? -42.78463 10.77113 2.31691   1.000 39.19487 ? 886 HOH   A O   1 
HETATM 3518 O  O   . HOH   L 6 .   ? -30.02076 38.26950 1.46994   1.000 32.71477 ? 887 HOH   A O   1 
HETATM 3519 O  O   . HOH   L 6 .   ? 0.54174   43.84373 -20.36780 1.000 35.02212 ? 888 HOH   A O   1 
HETATM 3520 O  O   . HOH   L 6 .   ? 1.81360   51.30369 -8.99125  1.000 39.45719 ? 889 HOH   A O   1 
HETATM 3521 O  O   . HOH   L 6 .   ? -35.53099 38.50970 3.83599   1.000 29.97766 ? 890 HOH   A O   1 
HETATM 3522 O  O   . HOH   L 6 .   ? -15.15956 39.57648 -0.29831  1.000 36.34275 ? 891 HOH   A O   1 
HETATM 3523 O  O   . HOH   L 6 .   ? -38.94479 34.61809 14.55986  1.000 27.88464 ? 892 HOH   A O   1 
HETATM 3524 O  O   . HOH   L 6 .   ? -18.36521 45.62946 -19.16029 1.000 35.01741 ? 893 HOH   A O   1 
HETATM 3525 O  O   . HOH   L 6 .   ? -27.37415 33.28631 15.66959  1.000 30.55063 ? 894 HOH   A O   1 
HETATM 3526 O  O   . HOH   L 6 .   ? -13.50904 35.46151 1.72618   1.000 38.31046 ? 895 HOH   A O   1 
HETATM 3527 O  O   . HOH   L 6 .   ? -28.23913 34.44304 13.52877  1.000 35.35627 ? 896 HOH   A O   1 
HETATM 3528 O  O   . HOH   L 6 .   ? -1.78924  48.75557 -20.39423 1.000 33.46160 ? 897 HOH   A O   1 
HETATM 3529 O  O   . HOH   L 6 .   ? -21.46656 11.09946 -15.97943 1.000 32.13095 ? 898 HOH   A O   1 
HETATM 3530 O  O   . HOH   L 6 .   ? -20.68283 34.59840 -1.24060  1.000 28.81733 ? 899 HOH   A O   1 
HETATM 3531 O  O   . HOH   L 6 .   ? -4.31807  20.46790 10.36211  1.000 35.83730 ? 900 HOH   A O   1 
HETATM 3532 O  O   . HOH   L 6 .   ? 1.20110   30.04115 -23.99335 1.000 39.92046 ? 901 HOH   A O   1 
# 
