data_9FK1
# 
_entry.id   9FK1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FK1         pdb_00009fk1 10.2210/pdb9fk1/pdb 
WWPDB D_1292138992 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FK1 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          Shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Chmelnik, O.' 2 ? 
'Dessau, M.'   3 ? 
'Shoham, Y.'   4 ? 
'Shoham, G.'   5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'The structure of glycosynthase XT6 (E265G mutant), the extracellular xylanase of G.proteiniphilus T-6' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Chmelnik, O.' 2 ? 
primary 'Dessau, M.'   3 ? 
primary 'Shoham, Y.'   4 ? 
primary 'Shoham, G.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Endo-1,4-beta-xylanase 43800.582 1   3.2.1.8 ? ? ? 
2 non-polymer syn 'ZINC ION'             65.409    8   ?       ? ? ? 
3 non-polymer syn 'CHLORIDE ION'         35.453    2   ?       ? ? ? 
4 water       nat water                  18.015    539 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Xylanase,1,4-beta-D-xylan xylanohydrolase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITGLDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'     ZN  
3 'CHLORIDE ION' CL  
4 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   ASN n 
1 3   ALA n 
1 4   ASP n 
1 5   SER n 
1 6   TYR n 
1 7   ALA n 
1 8   LYS n 
1 9   LYS n 
1 10  PRO n 
1 11  HIS n 
1 12  ILE n 
1 13  SER n 
1 14  ALA n 
1 15  LEU n 
1 16  ASN n 
1 17  ALA n 
1 18  PRO n 
1 19  GLN n 
1 20  LEU n 
1 21  ASP n 
1 22  GLN n 
1 23  ARG n 
1 24  TYR n 
1 25  LYS n 
1 26  ASN n 
1 27  GLU n 
1 28  PHE n 
1 29  THR n 
1 30  ILE n 
1 31  GLY n 
1 32  ALA n 
1 33  ALA n 
1 34  VAL n 
1 35  GLU n 
1 36  PRO n 
1 37  TYR n 
1 38  GLN n 
1 39  LEU n 
1 40  GLN n 
1 41  ASN n 
1 42  GLU n 
1 43  LYS n 
1 44  ASP n 
1 45  VAL n 
1 46  GLN n 
1 47  MET n 
1 48  LEU n 
1 49  LYS n 
1 50  ARG n 
1 51  HIS n 
1 52  PHE n 
1 53  ASN n 
1 54  SER n 
1 55  ILE n 
1 56  VAL n 
1 57  ALA n 
1 58  GLU n 
1 59  ASN n 
1 60  VAL n 
1 61  MET n 
1 62  LYS n 
1 63  PRO n 
1 64  ILE n 
1 65  SER n 
1 66  ILE n 
1 67  GLN n 
1 68  PRO n 
1 69  GLU n 
1 70  GLU n 
1 71  GLY n 
1 72  LYS n 
1 73  PHE n 
1 74  ASN n 
1 75  PHE n 
1 76  GLU n 
1 77  GLN n 
1 78  ALA n 
1 79  ASP n 
1 80  ARG n 
1 81  ILE n 
1 82  VAL n 
1 83  LYS n 
1 84  PHE n 
1 85  ALA n 
1 86  LYS n 
1 87  ALA n 
1 88  ASN n 
1 89  GLY n 
1 90  MET n 
1 91  ASP n 
1 92  ILE n 
1 93  ARG n 
1 94  PHE n 
1 95  HIS n 
1 96  THR n 
1 97  LEU n 
1 98  VAL n 
1 99  TRP n 
1 100 HIS n 
1 101 SER n 
1 102 GLN n 
1 103 VAL n 
1 104 PRO n 
1 105 GLN n 
1 106 TRP n 
1 107 PHE n 
1 108 PHE n 
1 109 LEU n 
1 110 ASP n 
1 111 LYS n 
1 112 GLU n 
1 113 GLY n 
1 114 LYS n 
1 115 PRO n 
1 116 MET n 
1 117 VAL n 
1 118 ASN n 
1 119 GLU n 
1 120 THR n 
1 121 ASP n 
1 122 PRO n 
1 123 VAL n 
1 124 LYS n 
1 125 ARG n 
1 126 GLU n 
1 127 GLN n 
1 128 ASN n 
1 129 LYS n 
1 130 GLN n 
1 131 LEU n 
1 132 LEU n 
1 133 LEU n 
1 134 LYS n 
1 135 ARG n 
1 136 LEU n 
1 137 GLU n 
1 138 THR n 
1 139 HIS n 
1 140 ILE n 
1 141 LYS n 
1 142 THR n 
1 143 ILE n 
1 144 VAL n 
1 145 GLU n 
1 146 ARG n 
1 147 TYR n 
1 148 LYS n 
1 149 ASP n 
1 150 ASP n 
1 151 ILE n 
1 152 LYS n 
1 153 TYR n 
1 154 TRP n 
1 155 ASP n 
1 156 VAL n 
1 157 VAL n 
1 158 ASN n 
1 159 GLU n 
1 160 VAL n 
1 161 VAL n 
1 162 GLY n 
1 163 ASP n 
1 164 ASP n 
1 165 GLY n 
1 166 LYS n 
1 167 LEU n 
1 168 ARG n 
1 169 ASN n 
1 170 SER n 
1 171 PRO n 
1 172 TRP n 
1 173 TYR n 
1 174 GLN n 
1 175 ILE n 
1 176 ALA n 
1 177 GLY n 
1 178 ILE n 
1 179 ASP n 
1 180 TYR n 
1 181 ILE n 
1 182 LYS n 
1 183 VAL n 
1 184 ALA n 
1 185 PHE n 
1 186 GLN n 
1 187 ALA n 
1 188 ALA n 
1 189 ARG n 
1 190 LYS n 
1 191 TYR n 
1 192 GLY n 
1 193 GLY n 
1 194 ASP n 
1 195 ASN n 
1 196 ILE n 
1 197 LYS n 
1 198 LEU n 
1 199 TYR n 
1 200 MET n 
1 201 ASN n 
1 202 ASP n 
1 203 TYR n 
1 204 ASN n 
1 205 THR n 
1 206 GLU n 
1 207 VAL n 
1 208 GLU n 
1 209 PRO n 
1 210 LYS n 
1 211 ARG n 
1 212 THR n 
1 213 ALA n 
1 214 LEU n 
1 215 TYR n 
1 216 ASN n 
1 217 LEU n 
1 218 VAL n 
1 219 LYS n 
1 220 GLN n 
1 221 LEU n 
1 222 LYS n 
1 223 GLU n 
1 224 GLU n 
1 225 GLY n 
1 226 VAL n 
1 227 PRO n 
1 228 ILE n 
1 229 ASP n 
1 230 GLY n 
1 231 ILE n 
1 232 GLY n 
1 233 HIS n 
1 234 GLN n 
1 235 SER n 
1 236 HIS n 
1 237 ILE n 
1 238 GLN n 
1 239 ILE n 
1 240 GLY n 
1 241 TRP n 
1 242 PRO n 
1 243 SER n 
1 244 GLU n 
1 245 ALA n 
1 246 GLU n 
1 247 ILE n 
1 248 GLU n 
1 249 LYS n 
1 250 THR n 
1 251 ILE n 
1 252 ASN n 
1 253 MET n 
1 254 PHE n 
1 255 ALA n 
1 256 ALA n 
1 257 LEU n 
1 258 GLY n 
1 259 LEU n 
1 260 ASP n 
1 261 ASN n 
1 262 GLN n 
1 263 ILE n 
1 264 THR n 
1 265 GLY n 
1 266 LEU n 
1 267 ASP n 
1 268 VAL n 
1 269 SER n 
1 270 MET n 
1 271 TYR n 
1 272 GLY n 
1 273 TRP n 
1 274 PRO n 
1 275 PRO n 
1 276 ARG n 
1 277 ALA n 
1 278 TYR n 
1 279 PRO n 
1 280 THR n 
1 281 TYR n 
1 282 ASP n 
1 283 ALA n 
1 284 ILE n 
1 285 PRO n 
1 286 LYS n 
1 287 GLN n 
1 288 LYS n 
1 289 PHE n 
1 290 LEU n 
1 291 ASP n 
1 292 GLN n 
1 293 ALA n 
1 294 ALA n 
1 295 ARG n 
1 296 TYR n 
1 297 ASP n 
1 298 ARG n 
1 299 LEU n 
1 300 PHE n 
1 301 LYS n 
1 302 LEU n 
1 303 TYR n 
1 304 GLU n 
1 305 LYS n 
1 306 LEU n 
1 307 SER n 
1 308 ASP n 
1 309 LYS n 
1 310 ILE n 
1 311 SER n 
1 312 ASN n 
1 313 VAL n 
1 314 THR n 
1 315 PHE n 
1 316 TRP n 
1 317 GLY n 
1 318 ILE n 
1 319 ALA n 
1 320 ASP n 
1 321 ASN n 
1 322 HIS n 
1 323 THR n 
1 324 TRP n 
1 325 LEU n 
1 326 ASP n 
1 327 SER n 
1 328 ARG n 
1 329 ALA n 
1 330 ASP n 
1 331 VAL n 
1 332 TYR n 
1 333 TYR n 
1 334 ASP n 
1 335 ALA n 
1 336 ASN n 
1 337 GLY n 
1 338 ASN n 
1 339 VAL n 
1 340 VAL n 
1 341 VAL n 
1 342 ASP n 
1 343 PRO n 
1 344 ASN n 
1 345 ALA n 
1 346 PRO n 
1 347 TYR n 
1 348 ALA n 
1 349 LYS n 
1 350 VAL n 
1 351 GLU n 
1 352 LYS n 
1 353 GLY n 
1 354 LYS n 
1 355 GLY n 
1 356 LYS n 
1 357 ASP n 
1 358 ALA n 
1 359 PRO n 
1 360 PHE n 
1 361 VAL n 
1 362 PHE n 
1 363 GLY n 
1 364 PRO n 
1 365 ASP n 
1 366 TYR n 
1 367 LYS n 
1 368 VAL n 
1 369 LYS n 
1 370 PRO n 
1 371 ALA n 
1 372 TYR n 
1 373 TRP n 
1 374 ALA n 
1 375 ILE n 
1 376 ILE n 
1 377 ASP n 
1 378 HIS n 
1 379 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   379 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus proteiniphilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     860353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ? 'Cl -1'          35.453  
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   ALA 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   5   SER SER A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   LYS 9   9   9   LYS LYS A . n 
A 1 10  PRO 10  10  10  PRO PRO A . n 
A 1 11  HIS 11  11  11  HIS HIS A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLN 22  22  22  GLN GLN A . n 
A 1 23  ARG 23  23  23  ARG ARG A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  PHE 28  28  28  PHE PHE A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  PRO 36  36  36  PRO PRO A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  GLN 40  40  40  GLN GLN A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  ASP 44  44  44  ASP ASP A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  LYS 49  49  49  LYS LYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  MET 61  61  61  MET MET A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  SER 65  65  65  SER SER A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  LYS 72  72  72  LYS LYS A . n 
A 1 73  PHE 73  73  73  PHE PHE A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  PHE 75  75  75  PHE PHE A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  GLN 77  77  77  GLN GLN A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  ASN 88  88  88  ASN ASN A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ARG 93  93  93  ARG ARG A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  HIS 95  95  95  HIS HIS A . n 
A 1 96  THR 96  96  96  THR THR A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  TRP 99  99  99  TRP TRP A . n 
A 1 100 HIS 100 100 100 HIS HIS A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 GLN 105 105 105 GLN GLN A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 GLU 112 112 112 GLU GLU A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 PRO 115 115 115 PRO PRO A . n 
A 1 116 MET 116 116 116 MET MET A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLU 126 126 126 GLU GLU A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 ASN 128 128 128 ASN ASN A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 ARG 135 135 135 ARG ARG A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 THR 138 138 138 THR THR A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 GLU 145 145 145 GLU GLU A . n 
A 1 146 ARG 146 146 146 ARG ARG A . n 
A 1 147 TYR 147 147 147 TYR TYR A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 ASP 149 149 149 ASP ASP A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 ILE 151 151 151 ILE ILE A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 TRP 154 154 154 TRP TRP A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ASN 158 158 158 ASN ASN A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 LYS 166 166 166 LYS LYS A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 ASN 169 169 169 ASN ASN A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 ILE 175 175 175 ILE ILE A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 TYR 180 180 180 TYR TYR A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 GLN 186 186 186 GLN GLN A . n 
A 1 187 ALA 187 187 187 ALA ALA A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 ASN 195 195 195 ASN ASN A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 LEU 198 198 198 LEU LEU A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 MET 200 200 200 MET MET A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 GLU 206 206 206 GLU GLU A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 GLU 208 208 208 GLU GLU A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 TYR 215 215 215 TYR TYR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 LYS 219 219 219 LYS LYS A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 TRP 241 241 241 TRP TRP A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 GLU 246 246 246 GLU GLU A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 ILE 251 251 251 ILE ILE A . n 
A 1 252 ASN 252 252 252 ASN ASN A . n 
A 1 253 MET 253 253 253 MET MET A . n 
A 1 254 PHE 254 254 254 PHE PHE A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 ASN 261 261 261 ASN ASN A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 THR 264 264 264 THR THR A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 SER 269 269 269 SER SER A . n 
A 1 270 MET 270 270 270 MET MET A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 TRP 273 273 273 TRP TRP A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 PRO 275 275 275 PRO PRO A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 TYR 278 278 278 TYR TYR A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 ILE 284 284 284 ILE ILE A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 GLN 287 287 287 GLN GLN A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ASP 291 291 291 ASP ASP A . n 
A 1 292 GLN 292 292 292 GLN GLN A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 TYR 296 296 296 TYR TYR A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 LEU 302 302 302 LEU LEU A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 SER 307 307 307 SER SER A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ILE 310 310 310 ILE ILE A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 THR 314 314 314 THR THR A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 TRP 316 316 316 TRP TRP A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 ILE 318 318 318 ILE ILE A . n 
A 1 319 ALA 319 319 319 ALA ALA A . n 
A 1 320 ASP 320 320 320 ASP ASP A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 HIS 322 322 322 HIS HIS A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 TRP 324 324 324 TRP TRP A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 ARG 328 328 328 ARG ARG A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ASP 330 330 330 ASP ASP A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
A 1 332 TYR 332 332 332 TYR TYR A . n 
A 1 333 TYR 333 333 333 TYR TYR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 ASN 344 344 344 ASN ASN A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 PRO 346 346 346 PRO PRO A . n 
A 1 347 TYR 347 347 347 TYR TYR A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 GLU 351 351 351 GLU GLU A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 LYS 354 354 354 LYS LYS A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LYS 356 356 356 LYS LYS A . n 
A 1 357 ASP 357 357 357 ASP ASP A . n 
A 1 358 ALA 358 358 358 ALA ALA A . n 
A 1 359 PRO 359 359 359 PRO PRO A . n 
A 1 360 PHE 360 360 360 PHE PHE A . n 
A 1 361 VAL 361 361 361 VAL VAL A . n 
A 1 362 PHE 362 362 362 PHE PHE A . n 
A 1 363 GLY 363 363 363 GLY GLY A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 ASP 365 365 365 ASP ASP A . n 
A 1 366 TYR 366 366 366 TYR TYR A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 PRO 370 370 370 PRO PRO A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 TYR 372 372 372 TYR TYR A . n 
A 1 373 TRP 373 373 373 TRP TRP A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 ASP 377 377 377 ASP ASP A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 LYS 379 379 379 LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   401  1   ZN  ZN  A . 
C 2 ZN  1   402  2   ZN  ZN  A . 
D 2 ZN  1   403  6   ZN  ZN  A . 
E 2 ZN  1   404  7   ZN  ZN  A . 
F 2 ZN  1   405  8   ZN  ZN  A . 
G 2 ZN  1   406  408 ZN  ZN  A . 
H 2 ZN  1   407  409 ZN  ZN  A . 
I 3 CL  1   408  412 CL  CL  A . 
J 2 ZN  1   409  413 ZN  ZN  A . 
K 3 CL  1   410  414 CL  CL  A . 
L 4 HOH 1   501  353 HOH HOH A . 
L 4 HOH 2   502  298 HOH HOH A . 
L 4 HOH 3   503  166 HOH HOH A . 
L 4 HOH 4   504  505 HOH HOH A . 
L 4 HOH 5   505  410 HOH HOH A . 
L 4 HOH 6   506  544 HOH HOH A . 
L 4 HOH 7   507  428 HOH HOH A . 
L 4 HOH 8   508  74  HOH HOH A . 
L 4 HOH 9   509  320 HOH HOH A . 
L 4 HOH 10  510  119 HOH HOH A . 
L 4 HOH 11  511  486 HOH HOH A . 
L 4 HOH 12  512  210 HOH HOH A . 
L 4 HOH 13  513  566 HOH HOH A . 
L 4 HOH 14  514  77  HOH HOH A . 
L 4 HOH 15  515  394 HOH HOH A . 
L 4 HOH 16  516  564 HOH HOH A . 
L 4 HOH 17  517  110 HOH HOH A . 
L 4 HOH 18  518  131 HOH HOH A . 
L 4 HOH 19  519  309 HOH HOH A . 
L 4 HOH 20  520  63  HOH HOH A . 
L 4 HOH 21  521  407 HOH HOH A . 
L 4 HOH 22  522  284 HOH HOH A . 
L 4 HOH 23  523  105 HOH HOH A . 
L 4 HOH 24  524  573 HOH HOH A . 
L 4 HOH 25  525  315 HOH HOH A . 
L 4 HOH 26  526  92  HOH HOH A . 
L 4 HOH 27  527  264 HOH HOH A . 
L 4 HOH 28  528  162 HOH HOH A . 
L 4 HOH 29  529  114 HOH HOH A . 
L 4 HOH 30  530  28  HOH HOH A . 
L 4 HOH 31  531  253 HOH HOH A . 
L 4 HOH 32  532  103 HOH HOH A . 
L 4 HOH 33  533  317 HOH HOH A . 
L 4 HOH 34  534  143 HOH HOH A . 
L 4 HOH 35  535  288 HOH HOH A . 
L 4 HOH 36  536  297 HOH HOH A . 
L 4 HOH 37  537  57  HOH HOH A . 
L 4 HOH 38  538  45  HOH HOH A . 
L 4 HOH 39  539  27  HOH HOH A . 
L 4 HOH 40  540  124 HOH HOH A . 
L 4 HOH 41  541  175 HOH HOH A . 
L 4 HOH 42  542  527 HOH HOH A . 
L 4 HOH 43  543  196 HOH HOH A . 
L 4 HOH 44  544  190 HOH HOH A . 
L 4 HOH 45  545  163 HOH HOH A . 
L 4 HOH 46  546  149 HOH HOH A . 
L 4 HOH 47  547  1   HOH HOH A . 
L 4 HOH 48  548  16  HOH HOH A . 
L 4 HOH 49  549  96  HOH HOH A . 
L 4 HOH 50  550  201 HOH HOH A . 
L 4 HOH 51  551  217 HOH HOH A . 
L 4 HOH 52  552  445 HOH HOH A . 
L 4 HOH 53  553  299 HOH HOH A . 
L 4 HOH 54  554  447 HOH HOH A . 
L 4 HOH 55  555  466 HOH HOH A . 
L 4 HOH 56  556  400 HOH HOH A . 
L 4 HOH 57  557  86  HOH HOH A . 
L 4 HOH 58  558  98  HOH HOH A . 
L 4 HOH 59  559  115 HOH HOH A . 
L 4 HOH 60  560  135 HOH HOH A . 
L 4 HOH 61  561  7   HOH HOH A . 
L 4 HOH 62  562  61  HOH HOH A . 
L 4 HOH 63  563  102 HOH HOH A . 
L 4 HOH 64  564  9   HOH HOH A . 
L 4 HOH 65  565  568 HOH HOH A . 
L 4 HOH 66  566  32  HOH HOH A . 
L 4 HOH 67  567  5   HOH HOH A . 
L 4 HOH 68  568  120 HOH HOH A . 
L 4 HOH 69  569  52  HOH HOH A . 
L 4 HOH 70  570  271 HOH HOH A . 
L 4 HOH 71  571  51  HOH HOH A . 
L 4 HOH 72  572  31  HOH HOH A . 
L 4 HOH 73  573  29  HOH HOH A . 
L 4 HOH 74  574  390 HOH HOH A . 
L 4 HOH 75  575  65  HOH HOH A . 
L 4 HOH 76  576  422 HOH HOH A . 
L 4 HOH 77  577  25  HOH HOH A . 
L 4 HOH 78  578  99  HOH HOH A . 
L 4 HOH 79  579  172 HOH HOH A . 
L 4 HOH 80  580  228 HOH HOH A . 
L 4 HOH 81  581  42  HOH HOH A . 
L 4 HOH 82  582  216 HOH HOH A . 
L 4 HOH 83  583  123 HOH HOH A . 
L 4 HOH 84  584  6   HOH HOH A . 
L 4 HOH 85  585  11  HOH HOH A . 
L 4 HOH 86  586  237 HOH HOH A . 
L 4 HOH 87  587  335 HOH HOH A . 
L 4 HOH 88  588  139 HOH HOH A . 
L 4 HOH 89  589  195 HOH HOH A . 
L 4 HOH 90  590  53  HOH HOH A . 
L 4 HOH 91  591  97  HOH HOH A . 
L 4 HOH 92  592  112 HOH HOH A . 
L 4 HOH 93  593  550 HOH HOH A . 
L 4 HOH 94  594  18  HOH HOH A . 
L 4 HOH 95  595  133 HOH HOH A . 
L 4 HOH 96  596  142 HOH HOH A . 
L 4 HOH 97  597  13  HOH HOH A . 
L 4 HOH 98  598  192 HOH HOH A . 
L 4 HOH 99  599  478 HOH HOH A . 
L 4 HOH 100 600  287 HOH HOH A . 
L 4 HOH 101 601  193 HOH HOH A . 
L 4 HOH 102 602  258 HOH HOH A . 
L 4 HOH 103 603  534 HOH HOH A . 
L 4 HOH 104 604  40  HOH HOH A . 
L 4 HOH 105 605  260 HOH HOH A . 
L 4 HOH 106 606  66  HOH HOH A . 
L 4 HOH 107 607  82  HOH HOH A . 
L 4 HOH 108 608  464 HOH HOH A . 
L 4 HOH 109 609  174 HOH HOH A . 
L 4 HOH 110 610  246 HOH HOH A . 
L 4 HOH 111 611  273 HOH HOH A . 
L 4 HOH 112 612  187 HOH HOH A . 
L 4 HOH 113 613  449 HOH HOH A . 
L 4 HOH 114 614  33  HOH HOH A . 
L 4 HOH 115 615  2   HOH HOH A . 
L 4 HOH 116 616  116 HOH HOH A . 
L 4 HOH 117 617  244 HOH HOH A . 
L 4 HOH 118 618  375 HOH HOH A . 
L 4 HOH 119 619  176 HOH HOH A . 
L 4 HOH 120 620  249 HOH HOH A . 
L 4 HOH 121 621  67  HOH HOH A . 
L 4 HOH 122 622  108 HOH HOH A . 
L 4 HOH 123 623  146 HOH HOH A . 
L 4 HOH 124 624  168 HOH HOH A . 
L 4 HOH 125 625  80  HOH HOH A . 
L 4 HOH 126 626  294 HOH HOH A . 
L 4 HOH 127 627  262 HOH HOH A . 
L 4 HOH 128 628  366 HOH HOH A . 
L 4 HOH 129 629  70  HOH HOH A . 
L 4 HOH 130 630  361 HOH HOH A . 
L 4 HOH 131 631  73  HOH HOH A . 
L 4 HOH 132 632  39  HOH HOH A . 
L 4 HOH 133 633  307 HOH HOH A . 
L 4 HOH 134 634  60  HOH HOH A . 
L 4 HOH 135 635  263 HOH HOH A . 
L 4 HOH 136 636  209 HOH HOH A . 
L 4 HOH 137 637  188 HOH HOH A . 
L 4 HOH 138 638  199 HOH HOH A . 
L 4 HOH 139 639  118 HOH HOH A . 
L 4 HOH 140 640  296 HOH HOH A . 
L 4 HOH 141 641  311 HOH HOH A . 
L 4 HOH 142 642  17  HOH HOH A . 
L 4 HOH 143 643  333 HOH HOH A . 
L 4 HOH 144 644  365 HOH HOH A . 
L 4 HOH 145 645  318 HOH HOH A . 
L 4 HOH 146 646  136 HOH HOH A . 
L 4 HOH 147 647  485 HOH HOH A . 
L 4 HOH 148 648  132 HOH HOH A . 
L 4 HOH 149 649  62  HOH HOH A . 
L 4 HOH 150 650  204 HOH HOH A . 
L 4 HOH 151 651  26  HOH HOH A . 
L 4 HOH 152 652  344 HOH HOH A . 
L 4 HOH 153 653  377 HOH HOH A . 
L 4 HOH 154 654  301 HOH HOH A . 
L 4 HOH 155 655  376 HOH HOH A . 
L 4 HOH 156 656  38  HOH HOH A . 
L 4 HOH 157 657  117 HOH HOH A . 
L 4 HOH 158 658  169 HOH HOH A . 
L 4 HOH 159 659  78  HOH HOH A . 
L 4 HOH 160 660  556 HOH HOH A . 
L 4 HOH 161 661  245 HOH HOH A . 
L 4 HOH 162 662  107 HOH HOH A . 
L 4 HOH 163 663  4   HOH HOH A . 
L 4 HOH 164 664  35  HOH HOH A . 
L 4 HOH 165 665  153 HOH HOH A . 
L 4 HOH 166 666  21  HOH HOH A . 
L 4 HOH 167 667  23  HOH HOH A . 
L 4 HOH 168 668  300 HOH HOH A . 
L 4 HOH 169 669  55  HOH HOH A . 
L 4 HOH 170 670  121 HOH HOH A . 
L 4 HOH 171 671  221 HOH HOH A . 
L 4 HOH 172 672  14  HOH HOH A . 
L 4 HOH 173 673  476 HOH HOH A . 
L 4 HOH 174 674  24  HOH HOH A . 
L 4 HOH 175 675  49  HOH HOH A . 
L 4 HOH 176 676  255 HOH HOH A . 
L 4 HOH 177 677  171 HOH HOH A . 
L 4 HOH 178 678  59  HOH HOH A . 
L 4 HOH 179 679  387 HOH HOH A . 
L 4 HOH 180 680  268 HOH HOH A . 
L 4 HOH 181 681  41  HOH HOH A . 
L 4 HOH 182 682  389 HOH HOH A . 
L 4 HOH 183 683  391 HOH HOH A . 
L 4 HOH 184 684  15  HOH HOH A . 
L 4 HOH 185 685  403 HOH HOH A . 
L 4 HOH 186 686  424 HOH HOH A . 
L 4 HOH 187 687  22  HOH HOH A . 
L 4 HOH 188 688  167 HOH HOH A . 
L 4 HOH 189 689  58  HOH HOH A . 
L 4 HOH 190 690  492 HOH HOH A . 
L 4 HOH 191 691  20  HOH HOH A . 
L 4 HOH 192 692  554 HOH HOH A . 
L 4 HOH 193 693  491 HOH HOH A . 
L 4 HOH 194 694  261 HOH HOH A . 
L 4 HOH 195 695  218 HOH HOH A . 
L 4 HOH 196 696  293 HOH HOH A . 
L 4 HOH 197 697  223 HOH HOH A . 
L 4 HOH 198 698  248 HOH HOH A . 
L 4 HOH 199 699  72  HOH HOH A . 
L 4 HOH 200 700  250 HOH HOH A . 
L 4 HOH 201 701  208 HOH HOH A . 
L 4 HOH 202 702  553 HOH HOH A . 
L 4 HOH 203 703  467 HOH HOH A . 
L 4 HOH 204 704  270 HOH HOH A . 
L 4 HOH 205 705  312 HOH HOH A . 
L 4 HOH 206 706  546 HOH HOH A . 
L 4 HOH 207 707  470 HOH HOH A . 
L 4 HOH 208 708  413 HOH HOH A . 
L 4 HOH 209 709  285 HOH HOH A . 
L 4 HOH 210 710  43  HOH HOH A . 
L 4 HOH 211 711  44  HOH HOH A . 
L 4 HOH 212 712  197 HOH HOH A . 
L 4 HOH 213 713  48  HOH HOH A . 
L 4 HOH 214 714  46  HOH HOH A . 
L 4 HOH 215 715  189 HOH HOH A . 
L 4 HOH 216 716  75  HOH HOH A . 
L 4 HOH 217 717  236 HOH HOH A . 
L 4 HOH 218 718  247 HOH HOH A . 
L 4 HOH 219 719  106 HOH HOH A . 
L 4 HOH 220 720  84  HOH HOH A . 
L 4 HOH 221 721  468 HOH HOH A . 
L 4 HOH 222 722  12  HOH HOH A . 
L 4 HOH 223 723  362 HOH HOH A . 
L 4 HOH 224 724  292 HOH HOH A . 
L 4 HOH 225 725  148 HOH HOH A . 
L 4 HOH 226 726  371 HOH HOH A . 
L 4 HOH 227 727  533 HOH HOH A . 
L 4 HOH 228 728  10  HOH HOH A . 
L 4 HOH 229 729  329 HOH HOH A . 
L 4 HOH 230 730  336 HOH HOH A . 
L 4 HOH 231 731  154 HOH HOH A . 
L 4 HOH 232 732  111 HOH HOH A . 
L 4 HOH 233 733  408 HOH HOH A . 
L 4 HOH 234 734  47  HOH HOH A . 
L 4 HOH 235 735  125 HOH HOH A . 
L 4 HOH 236 736  207 HOH HOH A . 
L 4 HOH 237 737  83  HOH HOH A . 
L 4 HOH 238 738  368 HOH HOH A . 
L 4 HOH 239 739  89  HOH HOH A . 
L 4 HOH 240 740  378 HOH HOH A . 
L 4 HOH 241 741  91  HOH HOH A . 
L 4 HOH 242 742  222 HOH HOH A . 
L 4 HOH 243 743  231 HOH HOH A . 
L 4 HOH 244 744  30  HOH HOH A . 
L 4 HOH 245 745  457 HOH HOH A . 
L 4 HOH 246 746  159 HOH HOH A . 
L 4 HOH 247 747  286 HOH HOH A . 
L 4 HOH 248 748  85  HOH HOH A . 
L 4 HOH 249 749  34  HOH HOH A . 
L 4 HOH 250 750  473 HOH HOH A . 
L 4 HOH 251 751  552 HOH HOH A . 
L 4 HOH 252 752  127 HOH HOH A . 
L 4 HOH 253 753  272 HOH HOH A . 
L 4 HOH 254 754  220 HOH HOH A . 
L 4 HOH 255 755  450 HOH HOH A . 
L 4 HOH 256 756  161 HOH HOH A . 
L 4 HOH 257 757  157 HOH HOH A . 
L 4 HOH 258 758  165 HOH HOH A . 
L 4 HOH 259 759  512 HOH HOH A . 
L 4 HOH 260 760  211 HOH HOH A . 
L 4 HOH 261 761  36  HOH HOH A . 
L 4 HOH 262 762  295 HOH HOH A . 
L 4 HOH 263 763  100 HOH HOH A . 
L 4 HOH 264 764  518 HOH HOH A . 
L 4 HOH 265 765  147 HOH HOH A . 
L 4 HOH 266 766  181 HOH HOH A . 
L 4 HOH 267 767  214 HOH HOH A . 
L 4 HOH 268 768  267 HOH HOH A . 
L 4 HOH 269 769  351 HOH HOH A . 
L 4 HOH 270 770  316 HOH HOH A . 
L 4 HOH 271 771  510 HOH HOH A . 
L 4 HOH 272 772  549 HOH HOH A . 
L 4 HOH 273 773  458 HOH HOH A . 
L 4 HOH 274 774  56  HOH HOH A . 
L 4 HOH 275 775  569 HOH HOH A . 
L 4 HOH 276 776  50  HOH HOH A . 
L 4 HOH 277 777  69  HOH HOH A . 
L 4 HOH 278 778  487 HOH HOH A . 
L 4 HOH 279 779  405 HOH HOH A . 
L 4 HOH 280 780  3   HOH HOH A . 
L 4 HOH 281 781  183 HOH HOH A . 
L 4 HOH 282 782  81  HOH HOH A . 
L 4 HOH 283 783  104 HOH HOH A . 
L 4 HOH 284 784  381 HOH HOH A . 
L 4 HOH 285 785  137 HOH HOH A . 
L 4 HOH 286 786  90  HOH HOH A . 
L 4 HOH 287 787  179 HOH HOH A . 
L 4 HOH 288 788  79  HOH HOH A . 
L 4 HOH 289 789  173 HOH HOH A . 
L 4 HOH 290 790  341 HOH HOH A . 
L 4 HOH 291 791  151 HOH HOH A . 
L 4 HOH 292 792  385 HOH HOH A . 
L 4 HOH 293 793  232 HOH HOH A . 
L 4 HOH 294 794  276 HOH HOH A . 
L 4 HOH 295 795  483 HOH HOH A . 
L 4 HOH 296 796  144 HOH HOH A . 
L 4 HOH 297 797  252 HOH HOH A . 
L 4 HOH 298 798  254 HOH HOH A . 
L 4 HOH 299 799  484 HOH HOH A . 
L 4 HOH 300 800  68  HOH HOH A . 
L 4 HOH 301 801  455 HOH HOH A . 
L 4 HOH 302 802  93  HOH HOH A . 
L 4 HOH 303 803  506 HOH HOH A . 
L 4 HOH 304 804  71  HOH HOH A . 
L 4 HOH 305 805  235 HOH HOH A . 
L 4 HOH 306 806  109 HOH HOH A . 
L 4 HOH 307 807  364 HOH HOH A . 
L 4 HOH 308 808  269 HOH HOH A . 
L 4 HOH 309 809  498 HOH HOH A . 
L 4 HOH 310 810  357 HOH HOH A . 
L 4 HOH 311 811  265 HOH HOH A . 
L 4 HOH 312 812  130 HOH HOH A . 
L 4 HOH 313 813  95  HOH HOH A . 
L 4 HOH 314 814  177 HOH HOH A . 
L 4 HOH 315 815  319 HOH HOH A . 
L 4 HOH 316 816  182 HOH HOH A . 
L 4 HOH 317 817  417 HOH HOH A . 
L 4 HOH 318 818  234 HOH HOH A . 
L 4 HOH 319 819  479 HOH HOH A . 
L 4 HOH 320 820  279 HOH HOH A . 
L 4 HOH 321 821  495 HOH HOH A . 
L 4 HOH 322 822  328 HOH HOH A . 
L 4 HOH 323 823  322 HOH HOH A . 
L 4 HOH 324 824  229 HOH HOH A . 
L 4 HOH 325 825  134 HOH HOH A . 
L 4 HOH 326 826  122 HOH HOH A . 
L 4 HOH 327 827  430 HOH HOH A . 
L 4 HOH 328 828  178 HOH HOH A . 
L 4 HOH 329 829  547 HOH HOH A . 
L 4 HOH 330 830  482 HOH HOH A . 
L 4 HOH 331 831  541 HOH HOH A . 
L 4 HOH 332 832  54  HOH HOH A . 
L 4 HOH 333 833  227 HOH HOH A . 
L 4 HOH 334 834  542 HOH HOH A . 
L 4 HOH 335 835  535 HOH HOH A . 
L 4 HOH 336 836  453 HOH HOH A . 
L 4 HOH 337 837  420 HOH HOH A . 
L 4 HOH 338 838  475 HOH HOH A . 
L 4 HOH 339 839  240 HOH HOH A . 
L 4 HOH 340 840  180 HOH HOH A . 
L 4 HOH 341 841  306 HOH HOH A . 
L 4 HOH 342 842  551 HOH HOH A . 
L 4 HOH 343 843  101 HOH HOH A . 
L 4 HOH 344 844  356 HOH HOH A . 
L 4 HOH 345 845  64  HOH HOH A . 
L 4 HOH 346 846  88  HOH HOH A . 
L 4 HOH 347 847  256 HOH HOH A . 
L 4 HOH 348 848  334 HOH HOH A . 
L 4 HOH 349 849  259 HOH HOH A . 
L 4 HOH 350 850  419 HOH HOH A . 
L 4 HOH 351 851  412 HOH HOH A . 
L 4 HOH 352 852  186 HOH HOH A . 
L 4 HOH 353 853  388 HOH HOH A . 
L 4 HOH 354 854  37  HOH HOH A . 
L 4 HOH 355 855  489 HOH HOH A . 
L 4 HOH 356 856  431 HOH HOH A . 
L 4 HOH 357 857  129 HOH HOH A . 
L 4 HOH 358 858  323 HOH HOH A . 
L 4 HOH 359 859  469 HOH HOH A . 
L 4 HOH 360 860  433 HOH HOH A . 
L 4 HOH 361 861  398 HOH HOH A . 
L 4 HOH 362 862  452 HOH HOH A . 
L 4 HOH 363 863  474 HOH HOH A . 
L 4 HOH 364 864  369 HOH HOH A . 
L 4 HOH 365 865  191 HOH HOH A . 
L 4 HOH 366 866  439 HOH HOH A . 
L 4 HOH 367 867  539 HOH HOH A . 
L 4 HOH 368 868  226 HOH HOH A . 
L 4 HOH 369 869  282 HOH HOH A . 
L 4 HOH 370 870  239 HOH HOH A . 
L 4 HOH 371 871  338 HOH HOH A . 
L 4 HOH 372 872  141 HOH HOH A . 
L 4 HOH 373 873  76  HOH HOH A . 
L 4 HOH 374 874  113 HOH HOH A . 
L 4 HOH 375 875  266 HOH HOH A . 
L 4 HOH 376 876  488 HOH HOH A . 
L 4 HOH 377 877  528 HOH HOH A . 
L 4 HOH 378 878  504 HOH HOH A . 
L 4 HOH 379 879  571 HOH HOH A . 
L 4 HOH 380 880  415 HOH HOH A . 
L 4 HOH 381 881  562 HOH HOH A . 
L 4 HOH 382 882  145 HOH HOH A . 
L 4 HOH 383 883  349 HOH HOH A . 
L 4 HOH 384 884  155 HOH HOH A . 
L 4 HOH 385 885  436 HOH HOH A . 
L 4 HOH 386 886  454 HOH HOH A . 
L 4 HOH 387 887  426 HOH HOH A . 
L 4 HOH 388 888  304 HOH HOH A . 
L 4 HOH 389 889  567 HOH HOH A . 
L 4 HOH 390 890  360 HOH HOH A . 
L 4 HOH 391 891  321 HOH HOH A . 
L 4 HOH 392 892  444 HOH HOH A . 
L 4 HOH 393 893  463 HOH HOH A . 
L 4 HOH 394 894  370 HOH HOH A . 
L 4 HOH 395 895  327 HOH HOH A . 
L 4 HOH 396 896  416 HOH HOH A . 
L 4 HOH 397 897  503 HOH HOH A . 
L 4 HOH 398 898  339 HOH HOH A . 
L 4 HOH 399 899  386 HOH HOH A . 
L 4 HOH 400 900  442 HOH HOH A . 
L 4 HOH 401 901  425 HOH HOH A . 
L 4 HOH 402 902  438 HOH HOH A . 
L 4 HOH 403 903  560 HOH HOH A . 
L 4 HOH 404 904  374 HOH HOH A . 
L 4 HOH 405 905  440 HOH HOH A . 
L 4 HOH 406 906  531 HOH HOH A . 
L 4 HOH 407 907  462 HOH HOH A . 
L 4 HOH 408 908  499 HOH HOH A . 
L 4 HOH 409 909  219 HOH HOH A . 
L 4 HOH 410 910  358 HOH HOH A . 
L 4 HOH 411 911  140 HOH HOH A . 
L 4 HOH 412 912  305 HOH HOH A . 
L 4 HOH 413 913  19  HOH HOH A . 
L 4 HOH 414 914  203 HOH HOH A . 
L 4 HOH 415 915  441 HOH HOH A . 
L 4 HOH 416 916  206 HOH HOH A . 
L 4 HOH 417 917  401 HOH HOH A . 
L 4 HOH 418 918  94  HOH HOH A . 
L 4 HOH 419 919  435 HOH HOH A . 
L 4 HOH 420 920  164 HOH HOH A . 
L 4 HOH 421 921  570 HOH HOH A . 
L 4 HOH 422 922  313 HOH HOH A . 
L 4 HOH 423 923  509 HOH HOH A . 
L 4 HOH 424 924  397 HOH HOH A . 
L 4 HOH 425 925  225 HOH HOH A . 
L 4 HOH 426 926  548 HOH HOH A . 
L 4 HOH 427 927  409 HOH HOH A . 
L 4 HOH 428 928  517 HOH HOH A . 
L 4 HOH 429 929  451 HOH HOH A . 
L 4 HOH 430 930  561 HOH HOH A . 
L 4 HOH 431 931  156 HOH HOH A . 
L 4 HOH 432 932  332 HOH HOH A . 
L 4 HOH 433 933  278 HOH HOH A . 
L 4 HOH 434 934  150 HOH HOH A . 
L 4 HOH 435 935  158 HOH HOH A . 
L 4 HOH 436 936  291 HOH HOH A . 
L 4 HOH 437 937  202 HOH HOH A . 
L 4 HOH 438 938  434 HOH HOH A . 
L 4 HOH 439 939  302 HOH HOH A . 
L 4 HOH 440 940  521 HOH HOH A . 
L 4 HOH 441 941  363 HOH HOH A . 
L 4 HOH 442 942  198 HOH HOH A . 
L 4 HOH 443 943  343 HOH HOH A . 
L 4 HOH 444 944  563 HOH HOH A . 
L 4 HOH 445 945  538 HOH HOH A . 
L 4 HOH 446 946  325 HOH HOH A . 
L 4 HOH 447 947  461 HOH HOH A . 
L 4 HOH 448 948  330 HOH HOH A . 
L 4 HOH 449 949  559 HOH HOH A . 
L 4 HOH 450 950  529 HOH HOH A . 
L 4 HOH 451 951  348 HOH HOH A . 
L 4 HOH 452 952  557 HOH HOH A . 
L 4 HOH 453 953  456 HOH HOH A . 
L 4 HOH 454 954  402 HOH HOH A . 
L 4 HOH 455 955  399 HOH HOH A . 
L 4 HOH 456 956  515 HOH HOH A . 
L 4 HOH 457 957  310 HOH HOH A . 
L 4 HOH 458 958  540 HOH HOH A . 
L 4 HOH 459 959  355 HOH HOH A . 
L 4 HOH 460 960  522 HOH HOH A . 
L 4 HOH 461 961  303 HOH HOH A . 
L 4 HOH 462 962  477 HOH HOH A . 
L 4 HOH 463 963  345 HOH HOH A . 
L 4 HOH 464 964  152 HOH HOH A . 
L 4 HOH 465 965  274 HOH HOH A . 
L 4 HOH 466 966  314 HOH HOH A . 
L 4 HOH 467 967  446 HOH HOH A . 
L 4 HOH 468 968  194 HOH HOH A . 
L 4 HOH 469 969  326 HOH HOH A . 
L 4 HOH 470 970  243 HOH HOH A . 
L 4 HOH 471 971  406 HOH HOH A . 
L 4 HOH 472 972  230 HOH HOH A . 
L 4 HOH 473 973  427 HOH HOH A . 
L 4 HOH 474 974  443 HOH HOH A . 
L 4 HOH 475 975  513 HOH HOH A . 
L 4 HOH 476 976  472 HOH HOH A . 
L 4 HOH 477 977  508 HOH HOH A . 
L 4 HOH 478 978  290 HOH HOH A . 
L 4 HOH 479 979  565 HOH HOH A . 
L 4 HOH 480 980  494 HOH HOH A . 
L 4 HOH 481 981  346 HOH HOH A . 
L 4 HOH 482 982  280 HOH HOH A . 
L 4 HOH 483 983  242 HOH HOH A . 
L 4 HOH 484 984  558 HOH HOH A . 
L 4 HOH 485 985  340 HOH HOH A . 
L 4 HOH 486 986  514 HOH HOH A . 
L 4 HOH 487 987  395 HOH HOH A . 
L 4 HOH 488 988  87  HOH HOH A . 
L 4 HOH 489 989  213 HOH HOH A . 
L 4 HOH 490 990  281 HOH HOH A . 
L 4 HOH 491 991  126 HOH HOH A . 
L 4 HOH 492 992  373 HOH HOH A . 
L 4 HOH 493 993  383 HOH HOH A . 
L 4 HOH 494 994  532 HOH HOH A . 
L 4 HOH 495 995  128 HOH HOH A . 
L 4 HOH 496 996  205 HOH HOH A . 
L 4 HOH 497 997  496 HOH HOH A . 
L 4 HOH 498 998  411 HOH HOH A . 
L 4 HOH 499 999  530 HOH HOH A . 
L 4 HOH 500 1000 392 HOH HOH A . 
L 4 HOH 501 1001 342 HOH HOH A . 
L 4 HOH 502 1002 418 HOH HOH A . 
L 4 HOH 503 1003 354 HOH HOH A . 
L 4 HOH 504 1004 367 HOH HOH A . 
L 4 HOH 505 1005 421 HOH HOH A . 
L 4 HOH 506 1006 432 HOH HOH A . 
L 4 HOH 507 1007 465 HOH HOH A . 
L 4 HOH 508 1008 350 HOH HOH A . 
L 4 HOH 509 1009 233 HOH HOH A . 
L 4 HOH 510 1010 459 HOH HOH A . 
L 4 HOH 511 1011 138 HOH HOH A . 
L 4 HOH 512 1012 212 HOH HOH A . 
L 4 HOH 513 1013 502 HOH HOH A . 
L 4 HOH 514 1014 184 HOH HOH A . 
L 4 HOH 515 1015 170 HOH HOH A . 
L 4 HOH 516 1016 352 HOH HOH A . 
L 4 HOH 517 1017 480 HOH HOH A . 
L 4 HOH 518 1018 380 HOH HOH A . 
L 4 HOH 519 1019 215 HOH HOH A . 
L 4 HOH 520 1020 379 HOH HOH A . 
L 4 HOH 521 1021 523 HOH HOH A . 
L 4 HOH 522 1022 423 HOH HOH A . 
L 4 HOH 523 1023 347 HOH HOH A . 
L 4 HOH 524 1024 537 HOH HOH A . 
L 4 HOH 525 1025 520 HOH HOH A . 
L 4 HOH 526 1026 160 HOH HOH A . 
L 4 HOH 527 1027 501 HOH HOH A . 
L 4 HOH 528 1028 224 HOH HOH A . 
L 4 HOH 529 1029 275 HOH HOH A . 
L 4 HOH 530 1030 289 HOH HOH A . 
L 4 HOH 531 1031 414 HOH HOH A . 
L 4 HOH 532 1032 481 HOH HOH A . 
L 4 HOH 533 1033 331 HOH HOH A . 
L 4 HOH 534 1034 238 HOH HOH A . 
L 4 HOH 535 1035 241 HOH HOH A . 
L 4 HOH 536 1036 337 HOH HOH A . 
L 4 HOH 537 1037 500 HOH HOH A . 
L 4 HOH 538 1038 490 HOH HOH A . 
L 4 HOH 539 1039 359 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   104.983 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FK1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     88.980 
_cell.length_a_esd                 ? 
_cell.length_b                     61.900 
_cell.length_b_esd                 ? 
_cell.length_c                     111.322 
_cell.length_c_esd                 ? 
_cell.volume                       592300.822 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FK1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FK1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.38 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          63.56 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.01M Zinc chloride, 17% PEG 5000, and 0.1M MES buffer at pH 6.5.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 200K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          17.89 
_reflns.entry_id                                       9FK1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.95 
_reflns.d_resolution_low                               39.83 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     42630 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.1 
_reflns.pdbx_Rpim_I_all                                0.04 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.09 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.95 
_reflns_shell.d_res_low                                     2.02 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.6 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2952 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.93 
_reflns_shell.pdbx_Rpim_I_all                               0.45 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.59 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.80 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.32 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FK1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             39.83 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42620 
_refine.ls_number_reflns_R_free                  2167 
_refine.ls_number_reflns_R_work                  40453 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.50 
_refine.ls_percent_reflns_R_free                 5.08 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1653 
_refine.ls_R_factor_R_free                       0.2053 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1631 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.5877 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1938 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        39.83 
_refine_hist.number_atoms_solvent             539 
_refine_hist.number_atoms_total               3616 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3067 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068 ? 3159 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7922 ? 4283 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0521 ? 443  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0052 ? 558  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.0418 ? 413  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 2.00  . . 126 2661 97.82  . . . . 0.2512 . . . . . . . . . . . 0.3195 
'X-RAY DIFFRACTION' 2.00 2.05  . . 161 2628 98.45  . . . . 0.2439 . . . . . . . . . . . 0.2742 
'X-RAY DIFFRACTION' 2.05 2.10  . . 143 2641 98.72  . . . . 0.2117 . . . . . . . . . . . 0.2632 
'X-RAY DIFFRACTION' 2.10 2.16  . . 125 2715 99.09  . . . . 0.1962 . . . . . . . . . . . 0.2647 
'X-RAY DIFFRACTION' 2.16 2.23  . . 147 2672 99.44  . . . . 0.1868 . . . . . . . . . . . 0.2042 
'X-RAY DIFFRACTION' 2.23 2.31  . . 139 2705 99.58  . . . . 0.1748 . . . . . . . . . . . 0.2125 
'X-RAY DIFFRACTION' 2.31 2.40  . . 130 2681 99.82  . . . . 0.1792 . . . . . . . . . . . 0.2464 
'X-RAY DIFFRACTION' 2.40 2.51  . . 166 2679 99.96  . . . . 0.1701 . . . . . . . . . . . 0.2418 
'X-RAY DIFFRACTION' 2.51 2.65  . . 139 2711 100.00 . . . . 0.1695 . . . . . . . . . . . 0.2152 
'X-RAY DIFFRACTION' 2.65 2.81  . . 166 2677 99.96  . . . . 0.1618 . . . . . . . . . . . 0.2171 
'X-RAY DIFFRACTION' 2.81 3.03  . . 134 2717 100.00 . . . . 0.1603 . . . . . . . . . . . 0.2202 
'X-RAY DIFFRACTION' 3.03 3.33  . . 148 2702 100.00 . . . . 0.1530 . . . . . . . . . . . 0.1988 
'X-RAY DIFFRACTION' 3.33 3.82  . . 157 2734 100.00 . . . . 0.1418 . . . . . . . . . . . 0.1739 
'X-RAY DIFFRACTION' 3.82 4.81  . . 127 2740 100.00 . . . . 0.1223 . . . . . . . . . . . 0.1591 
'X-RAY DIFFRACTION' 4.81 39.83 . . 159 2790 99.59  . . . . 0.1419 . . . . . . . . . . . 0.1533 
# 
_struct.entry_id                     9FK1 
_struct.title                        
'The structure of glycosynthase XT6 (E265G mutant), the extracellular xylanase of G.proteiniphilus T-6' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FK1 
_struct_keywords.text            'XT6, glycosynthase, hydrolase, Geobacillus proteiniphilus T-6' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 3 ? 
J N N 2 ? 
K N N 3 ? 
L N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    XYN1_GEOSE 
_struct_ref.pdbx_db_accession          P40943 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KNADSYAKKPHISALNAPQLDQRYKNEFTIGAAVEPYQLQNEKDVQMLKRHFNSIVAENVMKPISIQPEEGKFNFEQADR
IVKFAKANGMDIRFHTLVWHSQVPQWFFLDKEGKPMVNETDPVKREQNKQLLLKRLETHIKTIVERYKDDIKYWDVVNEV
VGDDGKLRNSPWYQIAGIDYIKVAFQAARKYGGDNIKLYMNDYNTEVEPKRTALYNLVKQLKEEGVPIDGIGHQSHIQIG
WPSEAEIEKTINMFAALGLDNQITELDVSMYGWPPRAYPTYDAIPKQKFLDQAARYDRLFKLYEKLSDKISNVTFWGIAD
NHTWLDSRADVYYDANGNVVVDPNAPYAKVEKGKGKDAPFVFGPDYKVKPAYWAIIDHK
;
_struct_ref.pdbx_align_begin           29 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FK1 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 379 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P40943 
_struct_ref_seq.db_align_beg                  29 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  407 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       379 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9FK1 
_struct_ref_seq_dif.mon_id                       GLY 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      265 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P40943 
_struct_ref_seq_dif.db_mon_id                    GLU 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          293 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            265 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1070  ? 
1 MORE         -248  ? 
1 'SSA (A^2)'  15810 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 13  ? ALA A 17  ? SER A 13  ALA A 17  5 ? 5  
HELX_P HELX_P2  AA2 GLN A 19  ? TYR A 24  ? GLN A 19  TYR A 24  1 ? 6  
HELX_P HELX_P3  AA3 GLU A 35  ? GLN A 40  ? GLU A 35  GLN A 40  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 41  ? PHE A 52  ? ASN A 41  PHE A 52  1 ? 12 
HELX_P HELX_P5  AA5 LYS A 62  ? GLN A 67  ? LYS A 62  GLN A 67  1 ? 6  
HELX_P HELX_P6  AA6 PHE A 75  ? ASN A 88  ? PHE A 75  ASN A 88  1 ? 14 
HELX_P HELX_P7  AA7 PRO A 104 ? LEU A 109 ? PRO A 104 LEU A 109 5 ? 6  
HELX_P HELX_P8  AA8 PRO A 115 ? GLU A 119 ? PRO A 115 GLU A 119 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 121 ? LYS A 148 ? ASP A 121 LYS A 148 1 ? 28 
HELX_P HELX_P10 AB1 SER A 170 ? GLY A 177 ? SER A 170 GLY A 177 1 ? 8  
HELX_P HELX_P11 AB2 ILE A 178 ? GLY A 193 ? ILE A 178 GLY A 193 1 ? 16 
HELX_P HELX_P12 AB3 PRO A 209 ? GLU A 224 ? PRO A 209 GLU A 224 1 ? 16 
HELX_P HELX_P13 AB4 SER A 243 ? LEU A 257 ? SER A 243 LEU A 257 1 ? 15 
HELX_P HELX_P14 AB5 THR A 280 ? ILE A 284 ? THR A 280 ILE A 284 5 ? 5  
HELX_P HELX_P15 AB6 PRO A 285 ? LEU A 306 ? PRO A 285 LEU A 306 1 ? 22 
HELX_P HELX_P16 AB7 THR A 323 ? ALA A 329 ? THR A 323 ALA A 329 5 ? 7  
HELX_P HELX_P17 AB8 LYS A 369 ? ASP A 377 ? LYS A 369 ASP A 377 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 11  NE2 ? ? ? 1_555 H ZN  . ZN ? ? A HIS 11  A ZN  407 1_555 ? ? ? ? ? ? ? 2.074 ? ? 
metalc2  metalc ? ? A ASP 21  OD2 ? ? ? 1_555 G ZN  . ZN ? ? A ASP 21  A ZN  406 1_555 ? ? ? ? ? ? ? 2.007 ? ? 
metalc3  metalc ? ? A GLU 27  O   ? ? ? 1_555 F ZN  . ZN ? ? A GLU 27  A ZN  405 1_555 ? ? ? ? ? ? ? 2.178 ? ? 
metalc4  metalc ? ? A GLU 27  OE2 ? ? ? 1_555 H ZN  . ZN ? ? A GLU 27  A ZN  407 4_444 ? ? ? ? ? ? ? 2.052 ? ? 
metalc5  metalc ? ? A GLU 58  OE1 ? ? ? 1_555 J ZN  . ZN ? ? A GLU 58  A ZN  409 1_555 ? ? ? ? ? ? ? 1.976 ? ? 
metalc6  metalc ? ? A ASP 282 OD1 ? ? ? 1_555 B ZN  . ZN ? ? A ASP 282 A ZN  401 4_454 ? ? ? ? ? ? ? 2.177 ? ? 
metalc7  metalc ? ? A ASP 282 OD2 ? ? ? 1_555 E ZN  . ZN ? ? A ASP 282 A ZN  404 1_555 ? ? ? ? ? ? ? 2.084 ? ? 
metalc8  metalc ? ? A ASP 297 OD1 ? ? ? 1_555 D ZN  . ZN ? ? A ASP 297 A ZN  403 1_555 ? ? ? ? ? ? ? 2.185 ? ? 
metalc9  metalc ? ? A SER 307 O   ? ? ? 1_555 F ZN  . ZN ? ? A SER 307 A ZN  405 1_555 ? ? ? ? ? ? ? 2.248 ? ? 
metalc10 metalc ? ? A ILE 310 O   ? ? ? 1_555 F ZN  . ZN ? ? A ILE 310 A ZN  405 1_555 ? ? ? ? ? ? ? 2.363 ? ? 
metalc11 metalc ? ? A HIS 322 NE2 ? ? ? 1_555 J ZN  . ZN ? ? A HIS 322 A ZN  409 1_555 ? ? ? ? ? ? ? 1.993 ? ? 
metalc12 metalc ? ? A ASP 365 OD2 ? ? ? 1_555 H ZN  . ZN ? ? A ASP 365 A ZN  407 1_555 ? ? ? ? ? ? ? 1.983 ? ? 
metalc13 metalc ? ? A ALA 374 O   ? ? ? 1_555 D ZN  . ZN ? ? A ALA 374 A ZN  403 1_555 ? ? ? ? ? ? ? 2.318 ? ? 
metalc14 metalc ? ? A ASP 377 OD1 ? ? ? 1_555 D ZN  . ZN ? ? A ASP 377 A ZN  403 1_555 ? ? ? ? ? ? ? 2.289 ? ? 
metalc15 metalc ? ? A HIS 378 NE2 ? ? ? 1_555 B ZN  . ZN ? ? A HIS 378 A ZN  401 1_555 ? ? ? ? ? ? ? 2.132 ? ? 
metalc16 metalc ? ? A LYS 379 O   ? ? ? 1_555 D ZN  . ZN ? ? A LYS 379 A ZN  403 1_555 ? ? ? ? ? ? ? 2.520 ? ? 
metalc17 metalc ? ? B ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  401 A HOH 829 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc18 metalc ? ? C ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  402 A HOH 746 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc19 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  403 A HOH 520 1_555 ? ? ? ? ? ? ? 2.547 ? ? 
metalc20 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  403 A HOH 583 1_555 ? ? ? ? ? ? ? 2.445 ? ? 
metalc21 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  403 A HOH 594 1_555 ? ? ? ? ? ? ? 2.581 ? ? 
metalc22 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  404 A HOH 544 4_454 ? ? ? ? ? ? ? 2.688 ? ? 
metalc23 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  404 A HOH 791 1_555 ? ? ? ? ? ? ? 2.372 ? ? 
metalc24 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  404 A HOH 948 4_454 ? ? ? ? ? ? ? 2.356 ? ? 
metalc25 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  405 A HOH 802 1_555 ? ? ? ? ? ? ? 2.680 ? ? 
metalc26 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  405 A HOH 854 1_555 ? ? ? ? ? ? ? 2.507 ? ? 
metalc27 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  405 A HOH 873 1_555 ? ? ? ? ? ? ? 2.543 ? ? 
metalc28 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 547 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc29 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 585 1_555 ? ? ? ? ? ? ? 2.036 ? ? 
metalc30 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 774 1_555 ? ? ? ? ? ? ? 2.201 ? ? 
metalc31 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 800 1_555 ? ? ? ? ? ? ? 2.150 ? ? 
metalc32 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  406 A HOH 913 1_555 ? ? ? ? ? ? ? 2.107 ? ? 
metalc33 metalc ? ? J ZN  .   ZN  ? ? ? 1_555 L HOH . O  ? ? A ZN  409 A HOH 530 1_555 ? ? ? ? ? ? ? 1.982 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? H ZN . ? A ZN 407 ? 1_555 OE2 ? A GLU 27  ? A GLU 27  ? 1_555 34.5  ? 
2  NE2 ? A HIS 11  ? A HIS 11  ? 1_555 ZN ? H ZN . ? A ZN 407 ? 1_555 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 120.9 ? 
3  OE2 ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? H ZN . ? A ZN 407 ? 1_555 OD2 ? A ASP 365 ? A ASP 365 ? 1_555 99.8  ? 
4  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 547 ? 1_555 91.7  ? 
5  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 585 ? 1_555 91.6  ? 
6  O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 585 ? 1_555 91.5  ? 
7  OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 774 ? 1_555 90.3  ? 
8  O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 774 ? 1_555 87.7  ? 
9  O   ? L HOH .   ? A HOH 585 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 774 ? 1_555 178.0 ? 
10 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 800 ? 1_555 94.1  ? 
11 O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 800 ? 1_555 174.0 ? 
12 O   ? L HOH .   ? A HOH 585 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 800 ? 1_555 89.9  ? 
13 O   ? L HOH .   ? A HOH 774 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 800 ? 1_555 90.7  ? 
14 OD2 ? A ASP 21  ? A ASP 21  ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 913 ? 1_555 178.2 ? 
15 O   ? L HOH .   ? A HOH 547 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 913 ? 1_555 88.1  ? 
16 O   ? L HOH .   ? A HOH 585 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 913 ? 1_555 86.6  ? 
17 O   ? L HOH .   ? A HOH 774 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 913 ? 1_555 91.5  ? 
18 O   ? L HOH .   ? A HOH 800 ? 1_555 ZN ? G ZN . ? A ZN 406 ? 1_555 O   ? L HOH .   ? A HOH 913 ? 1_555 86.2  ? 
19 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? A SER 307 ? A SER 307 ? 1_555 103.1 ? 
20 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 94.0  ? 
21 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? A ILE 310 ? A ILE 310 ? 1_555 86.2  ? 
22 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 802 ? 1_555 84.3  ? 
23 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 802 ? 1_555 85.8  ? 
24 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 802 ? 1_555 171.2 ? 
25 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 854 ? 1_555 88.5  ? 
26 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 854 ? 1_555 166.6 ? 
27 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 854 ? 1_555 99.9  ? 
28 O   ? L HOH .   ? A HOH 802 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 854 ? 1_555 88.7  ? 
29 O   ? A GLU 27  ? A GLU 27  ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 873 ? 1_555 162.4 ? 
30 O   ? A SER 307 ? A SER 307 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 873 ? 1_555 94.4  ? 
31 O   ? A ILE 310 ? A ILE 310 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 873 ? 1_555 89.0  ? 
32 O   ? L HOH .   ? A HOH 802 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 873 ? 1_555 95.2  ? 
33 O   ? L HOH .   ? A HOH 854 ? 1_555 ZN ? F ZN . ? A ZN 405 ? 1_555 O   ? L HOH .   ? A HOH 873 ? 1_555 73.9  ? 
34 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? J ZN . ? A ZN 409 ? 1_555 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 118.7 ? 
35 OE1 ? A GLU 58  ? A GLU 58  ? 1_555 ZN ? J ZN . ? A ZN 409 ? 1_555 O   ? L HOH .   ? A HOH 530 ? 1_555 98.2  ? 
36 NE2 ? A HIS 322 ? A HIS 322 ? 1_555 ZN ? J ZN . ? A ZN 409 ? 1_555 O   ? L HOH .   ? A HOH 530 ? 1_555 105.8 ? 
37 OD1 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 4_454 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 111.7 ? 
38 OD1 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 4_454 O   ? L HOH .   ? A HOH 829 ? 1_555 113.3 ? 
39 NE2 ? A HIS 378 ? A HIS 378 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 4_454 O   ? L HOH .   ? A HOH 829 ? 1_555 1.8   ? 
40 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 544 ? 4_454 93.6  ? 
41 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 791 ? 1_555 95.1  ? 
42 O   ? L HOH .   ? A HOH 544 ? 4_454 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 791 ? 1_555 161.2 ? 
43 OD2 ? A ASP 282 ? A ASP 282 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 948 ? 4_454 148.3 ? 
44 O   ? L HOH .   ? A HOH 544 ? 4_454 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 948 ? 4_454 74.7  ? 
45 O   ? L HOH .   ? A HOH 791 ? 1_555 ZN ? E ZN . ? A ZN 404 ? 1_555 O   ? L HOH .   ? A HOH 948 ? 4_454 89.3  ? 
46 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? A ALA 374 ? A ALA 374 ? 1_555 93.1  ? 
47 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 149.4 ? 
48 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 85.7  ? 
49 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 91.8  ? 
50 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 174.1 ? 
51 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? A LYS 379 ? A LYS 379 ? 1_555 88.5  ? 
52 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 520 ? 1_555 74.2  ? 
53 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 520 ? 1_555 87.2  ? 
54 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 520 ? 1_555 75.2  ? 
55 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 520 ? 1_555 91.1  ? 
56 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 583 ? 1_555 140.2 ? 
57 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 583 ? 1_555 91.8  ? 
58 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 583 ? 1_555 70.4  ? 
59 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 583 ? 1_555 86.4  ? 
60 O   ? L HOH .   ? A HOH 520 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 583 ? 1_555 145.5 ? 
61 OD1 ? A ASP 297 ? A ASP 297 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 70.7  ? 
62 O   ? A ALA 374 ? A ALA 374 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 91.7  ? 
63 OD1 ? A ASP 377 ? A ASP 377 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 139.8 ? 
64 O   ? A LYS 379 ? A LYS 379 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 92.9  ? 
65 O   ? L HOH .   ? A HOH 520 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 144.8 ? 
66 O   ? L HOH .   ? A HOH 583 ? 1_555 ZN ? D ZN . ? A ZN 403 ? 1_555 O   ? L HOH .   ? A HOH 594 ? 1_555 69.7  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 95  A . ? HIS 95  A THR 96  A ? THR 96  A 1 -0.69 
2 GLU 208 A . ? GLU 208 A PRO 209 A ? PRO 209 A 1 5.34  
3 TRP 241 A . ? TRP 241 A PRO 242 A ? PRO 242 A 1 -6.38 
4 TRP 273 A . ? TRP 273 A PRO 274 A ? PRO 274 A 1 -6.61 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA1 2 3  ? parallel      
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? parallel      
AA1 9 10 ? parallel      
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  HIS A 236 ? ILE A 237 ? HIS A 236 ILE A 237 
AA1 2  ASP A 260 ? VAL A 268 ? ASP A 260 VAL A 268 
AA1 3  ILE A 310 ? PHE A 315 ? ILE A 310 PHE A 315 
AA1 4  THR A 29  ? VAL A 34  ? THR A 29  VAL A 34  
AA1 5  SER A 54  ? ALA A 57  ? SER A 54  ALA A 57  
AA1 6  ASP A 91  ? HIS A 95  ? ASP A 91  HIS A 95  
AA1 7  TYR A 153 ? ASN A 158 ? TYR A 153 ASN A 158 
AA1 8  LYS A 197 ? ASP A 202 ? LYS A 197 ASP A 202 
AA1 9  GLY A 230 ? HIS A 233 ? GLY A 230 HIS A 233 
AA1 10 ASP A 260 ? VAL A 268 ? ASP A 260 VAL A 268 
AA2 1  VAL A 339 ? VAL A 340 ? VAL A 339 VAL A 340 
AA2 2  VAL A 331 ? TYR A 333 ? VAL A 331 TYR A 333 
AA2 3  LYS A 349 ? GLU A 351 ? LYS A 349 GLU A 351 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ILE A 237 ? N ILE A 237 O ASP A 267 ? O ASP A 267 
AA1 2 3  N ILE A 263 ? N ILE A 263 O THR A 314 ? O THR A 314 
AA1 3 4  O PHE A 315 ? O PHE A 315 N GLY A 31  ? N GLY A 31  
AA1 4 5  N VAL A 34  ? N VAL A 34  O VAL A 56  ? O VAL A 56  
AA1 5 6  N ILE A 55  ? N ILE A 55  O ARG A 93  ? O ARG A 93  
AA1 6 7  N PHE A 94  ? N PHE A 94  O ASP A 155 ? O ASP A 155 
AA1 7 8  N TRP A 154 ? N TRP A 154 O TYR A 199 ? O TYR A 199 
AA1 8 9  N MET A 200 ? N MET A 200 O GLY A 232 ? O GLY A 232 
AA1 9 10 N HIS A 233 ? N HIS A 233 O GLN A 262 ? O GLN A 262 
AA2 1 2  O VAL A 340 ? O VAL A 340 N TYR A 332 ? N TYR A 332 
AA2 2 3  N VAL A 331 ? N VAL A 331 O GLU A 351 ? O GLU A 351 
# 
_pdbx_entry_details.entry_id                   9FK1 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 861 ? ? O A HOH 923  ? ? 2.07 
2 1 O   A HOH 949 ? ? O A HOH 984  ? ? 2.15 
3 1 OE1 A GLU 137 ? ? O A HOH 501  ? ? 2.17 
4 1 O   A HOH 903 ? ? O A HOH 949  ? ? 2.18 
5 1 O   A HOH 860 ? ? O A HOH 1032 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 59  ? ? -144.05 -32.39 
2 1 ILE A 318 ? ? -107.62 -61.95 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 549 ? L HOH . 
2 1 A HOH 988 ? L HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1037 ? 5.84 . 
2 1 O ? A HOH 1038 ? 6.42 . 
3 1 O ? A HOH 1039 ? 6.46 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A LYS 1 ? A LYS 1 
2 1 Y 1 A ASN 2 ? A ASN 2 
3 1 Y 1 A ALA 3 ? A ALA 3 
4 1 Y 1 A ASP 4 ? A ASP 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
GLN N    N  N N 75  
GLN CA   C  N S 76  
GLN C    C  N N 77  
GLN O    O  N N 78  
GLN CB   C  N N 79  
GLN CG   C  N N 80  
GLN CD   C  N N 81  
GLN OE1  O  N N 82  
GLN NE2  N  N N 83  
GLN OXT  O  N N 84  
GLN H    H  N N 85  
GLN H2   H  N N 86  
GLN HA   H  N N 87  
GLN HB2  H  N N 88  
GLN HB3  H  N N 89  
GLN HG2  H  N N 90  
GLN HG3  H  N N 91  
GLN HE21 H  N N 92  
GLN HE22 H  N N 93  
GLN HXT  H  N N 94  
GLU N    N  N N 95  
GLU CA   C  N S 96  
GLU C    C  N N 97  
GLU O    O  N N 98  
GLU CB   C  N N 99  
GLU CG   C  N N 100 
GLU CD   C  N N 101 
GLU OE1  O  N N 102 
GLU OE2  O  N N 103 
GLU OXT  O  N N 104 
GLU H    H  N N 105 
GLU H2   H  N N 106 
GLU HA   H  N N 107 
GLU HB2  H  N N 108 
GLU HB3  H  N N 109 
GLU HG2  H  N N 110 
GLU HG3  H  N N 111 
GLU HE2  H  N N 112 
GLU HXT  H  N N 113 
GLY N    N  N N 114 
GLY CA   C  N N 115 
GLY C    C  N N 116 
GLY O    O  N N 117 
GLY OXT  O  N N 118 
GLY H    H  N N 119 
GLY H2   H  N N 120 
GLY HA2  H  N N 121 
GLY HA3  H  N N 122 
GLY HXT  H  N N 123 
HIS N    N  N N 124 
HIS CA   C  N S 125 
HIS C    C  N N 126 
HIS O    O  N N 127 
HIS CB   C  N N 128 
HIS CG   C  Y N 129 
HIS ND1  N  Y N 130 
HIS CD2  C  Y N 131 
HIS CE1  C  Y N 132 
HIS NE2  N  Y N 133 
HIS OXT  O  N N 134 
HIS H    H  N N 135 
HIS H2   H  N N 136 
HIS HA   H  N N 137 
HIS HB2  H  N N 138 
HIS HB3  H  N N 139 
HIS HD1  H  N N 140 
HIS HD2  H  N N 141 
HIS HE1  H  N N 142 
HIS HE2  H  N N 143 
HIS HXT  H  N N 144 
HOH O    O  N N 145 
HOH H1   H  N N 146 
HOH H2   H  N N 147 
ILE N    N  N N 148 
ILE CA   C  N S 149 
ILE C    C  N N 150 
ILE O    O  N N 151 
ILE CB   C  N S 152 
ILE CG1  C  N N 153 
ILE CG2  C  N N 154 
ILE CD1  C  N N 155 
ILE OXT  O  N N 156 
ILE H    H  N N 157 
ILE H2   H  N N 158 
ILE HA   H  N N 159 
ILE HB   H  N N 160 
ILE HG12 H  N N 161 
ILE HG13 H  N N 162 
ILE HG21 H  N N 163 
ILE HG22 H  N N 164 
ILE HG23 H  N N 165 
ILE HD11 H  N N 166 
ILE HD12 H  N N 167 
ILE HD13 H  N N 168 
ILE HXT  H  N N 169 
LEU N    N  N N 170 
LEU CA   C  N S 171 
LEU C    C  N N 172 
LEU O    O  N N 173 
LEU CB   C  N N 174 
LEU CG   C  N N 175 
LEU CD1  C  N N 176 
LEU CD2  C  N N 177 
LEU OXT  O  N N 178 
LEU H    H  N N 179 
LEU H2   H  N N 180 
LEU HA   H  N N 181 
LEU HB2  H  N N 182 
LEU HB3  H  N N 183 
LEU HG   H  N N 184 
LEU HD11 H  N N 185 
LEU HD12 H  N N 186 
LEU HD13 H  N N 187 
LEU HD21 H  N N 188 
LEU HD22 H  N N 189 
LEU HD23 H  N N 190 
LEU HXT  H  N N 191 
LYS N    N  N N 192 
LYS CA   C  N S 193 
LYS C    C  N N 194 
LYS O    O  N N 195 
LYS CB   C  N N 196 
LYS CG   C  N N 197 
LYS CD   C  N N 198 
LYS CE   C  N N 199 
LYS NZ   N  N N 200 
LYS OXT  O  N N 201 
LYS H    H  N N 202 
LYS H2   H  N N 203 
LYS HA   H  N N 204 
LYS HB2  H  N N 205 
LYS HB3  H  N N 206 
LYS HG2  H  N N 207 
LYS HG3  H  N N 208 
LYS HD2  H  N N 209 
LYS HD3  H  N N 210 
LYS HE2  H  N N 211 
LYS HE3  H  N N 212 
LYS HZ1  H  N N 213 
LYS HZ2  H  N N 214 
LYS HZ3  H  N N 215 
LYS HXT  H  N N 216 
MET N    N  N N 217 
MET CA   C  N S 218 
MET C    C  N N 219 
MET O    O  N N 220 
MET CB   C  N N 221 
MET CG   C  N N 222 
MET SD   S  N N 223 
MET CE   C  N N 224 
MET OXT  O  N N 225 
MET H    H  N N 226 
MET H2   H  N N 227 
MET HA   H  N N 228 
MET HB2  H  N N 229 
MET HB3  H  N N 230 
MET HG2  H  N N 231 
MET HG3  H  N N 232 
MET HE1  H  N N 233 
MET HE2  H  N N 234 
MET HE3  H  N N 235 
MET HXT  H  N N 236 
PHE N    N  N N 237 
PHE CA   C  N S 238 
PHE C    C  N N 239 
PHE O    O  N N 240 
PHE CB   C  N N 241 
PHE CG   C  Y N 242 
PHE CD1  C  Y N 243 
PHE CD2  C  Y N 244 
PHE CE1  C  Y N 245 
PHE CE2  C  Y N 246 
PHE CZ   C  Y N 247 
PHE OXT  O  N N 248 
PHE H    H  N N 249 
PHE H2   H  N N 250 
PHE HA   H  N N 251 
PHE HB2  H  N N 252 
PHE HB3  H  N N 253 
PHE HD1  H  N N 254 
PHE HD2  H  N N 255 
PHE HE1  H  N N 256 
PHE HE2  H  N N 257 
PHE HZ   H  N N 258 
PHE HXT  H  N N 259 
PRO N    N  N N 260 
PRO CA   C  N S 261 
PRO C    C  N N 262 
PRO O    O  N N 263 
PRO CB   C  N N 264 
PRO CG   C  N N 265 
PRO CD   C  N N 266 
PRO OXT  O  N N 267 
PRO H    H  N N 268 
PRO HA   H  N N 269 
PRO HB2  H  N N 270 
PRO HB3  H  N N 271 
PRO HG2  H  N N 272 
PRO HG3  H  N N 273 
PRO HD2  H  N N 274 
PRO HD3  H  N N 275 
PRO HXT  H  N N 276 
SER N    N  N N 277 
SER CA   C  N S 278 
SER C    C  N N 279 
SER O    O  N N 280 
SER CB   C  N N 281 
SER OG   O  N N 282 
SER OXT  O  N N 283 
SER H    H  N N 284 
SER H2   H  N N 285 
SER HA   H  N N 286 
SER HB2  H  N N 287 
SER HB3  H  N N 288 
SER HG   H  N N 289 
SER HXT  H  N N 290 
THR N    N  N N 291 
THR CA   C  N S 292 
THR C    C  N N 293 
THR O    O  N N 294 
THR CB   C  N R 295 
THR OG1  O  N N 296 
THR CG2  C  N N 297 
THR OXT  O  N N 298 
THR H    H  N N 299 
THR H2   H  N N 300 
THR HA   H  N N 301 
THR HB   H  N N 302 
THR HG1  H  N N 303 
THR HG21 H  N N 304 
THR HG22 H  N N 305 
THR HG23 H  N N 306 
THR HXT  H  N N 307 
TRP N    N  N N 308 
TRP CA   C  N S 309 
TRP C    C  N N 310 
TRP O    O  N N 311 
TRP CB   C  N N 312 
TRP CG   C  Y N 313 
TRP CD1  C  Y N 314 
TRP CD2  C  Y N 315 
TRP NE1  N  Y N 316 
TRP CE2  C  Y N 317 
TRP CE3  C  Y N 318 
TRP CZ2  C  Y N 319 
TRP CZ3  C  Y N 320 
TRP CH2  C  Y N 321 
TRP OXT  O  N N 322 
TRP H    H  N N 323 
TRP H2   H  N N 324 
TRP HA   H  N N 325 
TRP HB2  H  N N 326 
TRP HB3  H  N N 327 
TRP HD1  H  N N 328 
TRP HE1  H  N N 329 
TRP HE3  H  N N 330 
TRP HZ2  H  N N 331 
TRP HZ3  H  N N 332 
TRP HH2  H  N N 333 
TRP HXT  H  N N 334 
TYR N    N  N N 335 
TYR CA   C  N S 336 
TYR C    C  N N 337 
TYR O    O  N N 338 
TYR CB   C  N N 339 
TYR CG   C  Y N 340 
TYR CD1  C  Y N 341 
TYR CD2  C  Y N 342 
TYR CE1  C  Y N 343 
TYR CE2  C  Y N 344 
TYR CZ   C  Y N 345 
TYR OH   O  N N 346 
TYR OXT  O  N N 347 
TYR H    H  N N 348 
TYR H2   H  N N 349 
TYR HA   H  N N 350 
TYR HB2  H  N N 351 
TYR HB3  H  N N 352 
TYR HD1  H  N N 353 
TYR HD2  H  N N 354 
TYR HE1  H  N N 355 
TYR HE2  H  N N 356 
TYR HH   H  N N 357 
TYR HXT  H  N N 358 
VAL N    N  N N 359 
VAL CA   C  N S 360 
VAL C    C  N N 361 
VAL O    O  N N 362 
VAL CB   C  N N 363 
VAL CG1  C  N N 364 
VAL CG2  C  N N 365 
VAL OXT  O  N N 366 
VAL H    H  N N 367 
VAL H2   H  N N 368 
VAL HA   H  N N 369 
VAL HB   H  N N 370 
VAL HG11 H  N N 371 
VAL HG12 H  N N 372 
VAL HG13 H  N N 373 
VAL HG21 H  N N 374 
VAL HG22 H  N N 375 
VAL HG23 H  N N 376 
VAL HXT  H  N N 377 
ZN  ZN   ZN N N 378 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1R85 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FK1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011238 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003008 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016155 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009299 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 5   ? -4.56371  30.30722 -26.31539 1.000 40.23692 ? 5    SER A N   1 
ATOM   2    C  CA  . SER A 1 5   ? -4.17543  29.47418 -27.45109 1.000 56.61036 ? 5    SER A CA  1 
ATOM   3    C  C   . SER A 1 5   ? -3.85653  30.29518 -28.70977 1.000 80.80525 ? 5    SER A C   1 
ATOM   4    O  O   . SER A 1 5   ? -2.68541  30.38633 -29.11472 1.000 73.91985 ? 5    SER A O   1 
ATOM   5    C  CB  . SER A 1 5   ? -5.27171  28.46485 -27.77808 1.000 34.71431 ? 5    SER A CB  1 
ATOM   6    O  OG  . SER A 1 5   ? -6.13491  28.97385 -28.78640 1.000 42.75429 ? 5    SER A OG  1 
ATOM   7    N  N   . TYR A 1 6   ? -4.89864  30.86195 -29.34350 1.000 78.79979 ? 6    TYR A N   1 
ATOM   8    C  CA  . TYR A 1 6   ? -4.75738  31.53605 -30.63118 1.000 72.12093 ? 6    TYR A CA  1 
ATOM   9    C  C   . TYR A 1 6   ? -5.36895  32.93018 -30.59654 1.000 70.33673 ? 6    TYR A C   1 
ATOM   10   O  O   . TYR A 1 6   ? -6.46409  33.13184 -30.05978 1.000 55.95264 ? 6    TYR A O   1 
ATOM   11   C  CB  . TYR A 1 6   ? -5.38956  30.71640 -31.77931 1.000 63.50813 ? 6    TYR A CB  1 
ATOM   12   C  CG  . TYR A 1 6   ? -4.52029  29.55772 -32.23070 1.000 71.77542 ? 6    TYR A CG  1 
ATOM   13   C  CD1 . TYR A 1 6   ? -4.17923  29.39305 -33.56599 1.000 73.83164 ? 6    TYR A CD1 1 
ATOM   14   C  CD2 . TYR A 1 6   ? -4.04661  28.62135 -31.31677 1.000 75.74066 ? 6    TYR A CD2 1 
ATOM   15   C  CE1 . TYR A 1 6   ? -3.37432  28.33190 -33.97165 1.000 85.11360 ? 6    TYR A CE1 1 
ATOM   16   C  CE2 . TYR A 1 6   ? -3.24535  27.56459 -31.70521 1.000 77.73851 ? 6    TYR A CE2 1 
ATOM   17   C  CZ  . TYR A 1 6   ? -2.91217  27.41784 -33.03188 1.000 89.39673 ? 6    TYR A CZ  1 
ATOM   18   O  OH  . TYR A 1 6   ? -2.11757  26.35668 -33.41013 1.000 93.24322 ? 6    TYR A OH  1 
ATOM   19   N  N   . ALA A 1 7   ? -4.63786  33.89066 -31.17628 1.000 70.22060 ? 7    ALA A N   1 
ATOM   20   C  CA  . ALA A 1 7   ? -5.12110  35.25021 -31.37387 1.000 62.42519 ? 7    ALA A CA  1 
ATOM   21   C  C   . ALA A 1 7   ? -5.48691  35.55318 -32.81995 1.000 64.07493 ? 7    ALA A C   1 
ATOM   22   O  O   . ALA A 1 7   ? -6.20592  36.53065 -33.06533 1.000 66.71332 ? 7    ALA A O   1 
ATOM   23   C  CB  . ALA A 1 7   ? -4.07536  36.27209 -30.90207 1.000 60.00333 ? 7    ALA A CB  1 
ATOM   24   N  N   . LYS A 1 8   ? -5.00054  34.75105 -33.77745 1.000 62.32786 ? 8    LYS A N   1 
ATOM   25   C  CA  . LYS A 1 8   ? -5.51931  34.80855 -35.14225 1.000 63.58665 ? 8    LYS A CA  1 
ATOM   26   C  C   . LYS A 1 8   ? -7.03052  34.61502 -35.15666 1.000 49.95396 ? 8    LYS A C   1 
ATOM   27   O  O   . LYS A 1 8   ? -7.74063  35.22473 -35.96509 1.000 48.79366 ? 8    LYS A O   1 
ATOM   28   C  CB  . LYS A 1 8   ? -4.85033  33.73548 -36.01004 1.000 61.45197 ? 8    LYS A CB  1 
ATOM   29   C  CG  . LYS A 1 8   ? -5.16452  32.30565 -35.55420 1.000 66.05150 ? 8    LYS A CG  1 
ATOM   30   C  CD  . LYS A 1 8   ? -4.72752  31.24850 -36.55054 1.000 64.81337 ? 8    LYS A CD  1 
ATOM   31   C  CE  . LYS A 1 8   ? -5.79291  30.16385 -36.69504 1.000 57.01383 ? 8    LYS A CE  1 
ATOM   32   N  NZ  . LYS A 1 8   ? -7.08491  30.70468 -37.23155 1.000 50.38170 ? 8    LYS A NZ  1 
ATOM   33   N  N   . LYS A 1 9   ? -7.53435  33.77251 -34.26332 1.000 43.42989 ? 9    LYS A N   1 
ATOM   34   C  CA  . LYS A 1 9   ? -8.92995  33.39353 -34.30043 1.000 30.95154 ? 9    LYS A CA  1 
ATOM   35   C  C   . LYS A 1 9   ? -9.79889  34.59626 -33.94359 1.000 27.48049 ? 9    LYS A C   1 
ATOM   36   O  O   . LYS A 1 9   ? -9.50331  35.30618 -32.97389 1.000 24.53769 ? 9    LYS A O   1 
ATOM   37   C  CB  . LYS A 1 9   ? -9.17114  32.23246 -33.34810 1.000 34.68859 ? 9    LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 9   ? -8.46105  30.96644 -33.78737 1.000 35.95407 ? 9    LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 9   ? -9.32937  30.13347 -34.73193 1.000 37.85080 ? 9    LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 9   ? -8.69091  28.75934 -34.95180 1.000 51.42383 ? 9    LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 9   ? -8.11040  28.21152 -33.66847 1.000 53.19483 ? 9    LYS A NZ  1 
ATOM   42   N  N   . PRO A 1 10  ? -10.85905 34.85562 -34.69458 1.000 22.09970 ? 10   PRO A N   1 
ATOM   43   C  CA  . PRO A 1 10  ? -11.51810 36.16067 -34.62625 1.000 18.48380 ? 10   PRO A CA  1 
ATOM   44   C  C   . PRO A 1 10  ? -12.42220 36.32142 -33.41050 1.000 16.71278 ? 10   PRO A C   1 
ATOM   45   O  O   . PRO A 1 10  ? -12.86881 35.36114 -32.77781 1.000 11.96342 ? 10   PRO A O   1 
ATOM   46   C  CB  . PRO A 1 10  ? -12.33644 36.19859 -35.91869 1.000 17.02018 ? 10   PRO A CB  1 
ATOM   47   C  CG  . PRO A 1 10  ? -12.62259 34.75642 -36.20663 1.000 22.93866 ? 10   PRO A CG  1 
ATOM   48   C  CD  . PRO A 1 10  ? -11.41225 33.99761 -35.75859 1.000 22.06469 ? 10   PRO A CD  1 
ATOM   49   N  N   . HIS A 1 11  ? -12.69673 37.59033 -33.11630 1.000 12.73609 ? 11   HIS A N   1 
ATOM   50   C  CA  . HIS A 1 11  ? -13.57553 38.02074 -32.02669 1.000 13.00838 ? 11   HIS A CA  1 
ATOM   51   C  C   . HIS A 1 11  ? -15.01210 38.07374 -32.55902 1.000 15.73533 ? 11   HIS A C   1 
ATOM   52   O  O   . HIS A 1 11  ? -15.63546 39.12633 -32.67179 1.000 14.73163 ? 11   HIS A O   1 
ATOM   53   C  CB  . HIS A 1 11  ? -13.08007 39.37289 -31.51530 1.000 13.00254 ? 11   HIS A CB  1 
ATOM   54   C  CG  . HIS A 1 11  ? -13.76494 39.90885 -30.29542 1.000 13.77279 ? 11   HIS A CG  1 
ATOM   55   N  ND1 . HIS A 1 11  ? -13.87831 39.20201 -29.11730 1.000 10.53212 ? 11   HIS A ND1 1 
ATOM   56   C  CD2 . HIS A 1 11  ? -14.27943 41.13734 -30.04518 1.000 11.76855 ? 11   HIS A CD2 1 
ATOM   57   C  CE1 . HIS A 1 11  ? -14.47078 39.95659 -28.20974 1.000 14.03039 ? 11   HIS A CE1 1 
ATOM   58   N  NE2 . HIS A 1 11  ? -14.72471 41.13591 -28.74678 1.000 13.88310 ? 11   HIS A NE2 1 
ATOM   59   N  N   . ILE A 1 12  ? -15.53584 36.89600 -32.91365 1.000 13.10846 ? 12   ILE A N   1 
ATOM   60   C  CA  . ILE A 1 12  ? -16.86205 36.79975 -33.51730 1.000 15.70259 ? 12   ILE A CA  1 
ATOM   61   C  C   . ILE A 1 12  ? -17.92998 36.69071 -32.43560 1.000 13.43358 ? 12   ILE A C   1 
ATOM   62   O  O   . ILE A 1 12  ? -17.66431 36.31086 -31.29353 1.000 13.70594 ? 12   ILE A O   1 
ATOM   63   C  CB  . ILE A 1 12  ? -16.97259 35.60133 -34.47900 1.000 17.26699 ? 12   ILE A CB  1 
ATOM   64   C  CG1 . ILE A 1 12  ? -16.65124 34.30368 -33.72943 1.000 13.78197 ? 12   ILE A CG1 1 
ATOM   65   C  CG2 . ILE A 1 12  ? -16.09556 35.80910 -35.71763 1.000 16.65946 ? 12   ILE A CG2 1 
ATOM   66   C  CD1 . ILE A 1 12  ? -17.04242 33.03650 -34.47935 1.000 16.89380 ? 12   ILE A CD1 1 
ATOM   67   N  N   . SER A 1 13  ? -19.16348 37.01198 -32.81433 1.000 12.73862 ? 13   SER A N   1 
ATOM   68   C  CA  . SER A 1 13  ? -20.30164 36.80131 -31.92581 1.000 16.37760 ? 13   SER A CA  1 
ATOM   69   C  C   . SER A 1 13  ? -20.36455 35.34459 -31.48311 1.000 13.58479 ? 13   SER A C   1 
ATOM   70   O  O   . SER A 1 13  ? -20.27174 34.42645 -32.30220 1.000 12.52401 ? 13   SER A O   1 
ATOM   71   C  CB  . SER A 1 13  ? -21.60909 37.18677 -32.62311 1.000 13.78036 ? 13   SER A CB  1 
ATOM   72   O  OG  . SER A 1 13  ? -22.73619 36.75497 -31.86694 1.000 14.98742 ? 13   SER A OG  1 
ATOM   73   N  N   . ALA A 1 14  ? -20.52164 35.14284 -30.17454 1.000 13.03781 ? 14   ALA A N   1 
ATOM   74   C  CA  . ALA A 1 14  ? -20.67623 33.79327 -29.63840 1.000 13.23811 ? 14   ALA A CA  1 
ATOM   75   C  C   . ALA A 1 14  ? -21.92423 33.10445 -30.17172 1.000 16.89562 ? 14   ALA A C   1 
ATOM   76   O  O   . ALA A 1 14  ? -22.02329 31.87710 -30.11441 1.000 13.75068 ? 14   ALA A O   1 
ATOM   77   C  CB  . ALA A 1 14  ? -20.72897 33.84254 -28.10858 1.000 11.41661 ? 14   ALA A CB  1 
ATOM   78   N  N   . LEU A 1 15  ? -22.89563 33.86457 -30.66088 1.000 16.25985 ? 15   LEU A N   1 
ATOM   79   C  CA  . LEU A 1 15  ? -24.10229 33.25662 -31.20815 1.000 18.09534 ? 15   LEU A CA  1 
ATOM   80   C  C   . LEU A 1 15  ? -23.85240 32.65577 -32.58677 1.000 18.07077 ? 15   LEU A C   1 
ATOM   81   O  O   . LEU A 1 15  ? -24.72178 31.95951 -33.11467 1.000 23.81105 ? 15   LEU A O   1 
ATOM   82   C  CB  . LEU A 1 15  ? -25.22500 34.30017 -31.24506 1.000 15.97983 ? 15   LEU A CB  1 
ATOM   83   C  CG  . LEU A 1 15  ? -25.81357 34.81129 -29.91840 1.000 25.88033 ? 15   LEU A CG  1 
ATOM   84   C  CD1 . LEU A 1 15  ? -24.81577 35.56353 -29.03857 1.000 35.13786 ? 15   LEU A CD1 1 
ATOM   85   C  CD2 . LEU A 1 15  ? -27.02510 35.70075 -30.18604 1.000 31.72621 ? 15   LEU A CD2 1 
ATOM   86   N  N   . ASN A 1 16  ? -22.67118 32.89417 -33.16158 1.000 24.00263 ? 16   ASN A N   1 
ATOM   87   C  CA  . ASN A 1 16  ? -22.21309 32.28877 -34.40784 1.000 28.47120 ? 16   ASN A CA  1 
ATOM   88   C  C   . ASN A 1 16  ? -21.02185 31.36675 -34.18450 1.000 29.76565 ? 16   ASN A C   1 
ATOM   89   O  O   . ASN A 1 16  ? -20.29568 31.04693 -35.13474 1.000 29.11670 ? 16   ASN A O   1 
ATOM   90   C  CB  . ASN A 1 16  ? -21.83417 33.37510 -35.41599 1.000 28.26313 ? 16   ASN A CB  1 
ATOM   91   C  CG  . ASN A 1 16  ? -23.01060 34.24108 -35.79600 1.000 36.17055 ? 16   ASN A CG  1 
ATOM   92   O  OD1 . ASN A 1 16  ? -24.16129 33.81037 -35.69627 1.000 40.70122 ? 16   ASN A OD1 1 
ATOM   93   N  ND2 . ASN A 1 16  ? -22.73363 35.47706 -36.22546 1.000 39.36152 ? 16   ASN A ND2 1 
ATOM   94   N  N   . ALA A 1 17  ? -20.78196 30.96756 -32.94235 1.000 19.87280 ? 17   ALA A N   1 
ATOM   95   C  CA  . ALA A 1 17  ? -19.59973 30.19070 -32.65125 1.000 18.94081 ? 17   ALA A CA  1 
ATOM   96   C  C   . ALA A 1 17  ? -19.97937 28.73492 -32.39793 1.000 13.09056 ? 17   ALA A C   1 
ATOM   97   O  O   . ALA A 1 17  ? -21.11154 28.45055 -31.99266 1.000 13.92136 ? 17   ALA A O   1 
ATOM   98   C  CB  . ALA A 1 17  ? -18.85818 30.75082 -31.43203 1.000 14.74504 ? 17   ALA A CB  1 
ATOM   99   N  N   . PRO A 1 18  ? -19.07568 27.79476 -32.68421 1.000 14.69969 ? 18   PRO A N   1 
ATOM   100  C  CA  . PRO A 1 18  ? -19.32603 26.38804 -32.33224 1.000 12.78118 ? 18   PRO A CA  1 
ATOM   101  C  C   . PRO A 1 18  ? -19.75335 26.23537 -30.87559 1.000 15.49069 ? 18   PRO A C   1 
ATOM   102  O  O   . PRO A 1 18  ? -19.21804 26.88963 -29.97337 1.000 11.55010 ? 18   PRO A O   1 
ATOM   103  C  CB  . PRO A 1 18  ? -17.97802 25.71192 -32.59370 1.000 11.18631 ? 18   PRO A CB  1 
ATOM   104  C  CG  . PRO A 1 18  ? -17.35696 26.54389 -33.70160 1.000 17.03817 ? 18   PRO A CG  1 
ATOM   105  C  CD  . PRO A 1 18  ? -17.84569 27.96594 -33.48524 1.000 16.29846 ? 18   PRO A CD  1 
ATOM   106  N  N   . GLN A 1 19  ? -20.71777 25.34268 -30.65594 1.000 11.49538 ? 19   GLN A N   1 
ATOM   107  C  CA  . GLN A 1 19  ? -21.38595 25.25135 -29.36509 1.000 12.93076 ? 19   GLN A CA  1 
ATOM   108  C  C   . GLN A 1 19  ? -20.48804 24.58748 -28.33197 1.000 15.21934 ? 19   GLN A C   1 
ATOM   109  O  O   . GLN A 1 19  ? -19.96440 23.48612 -28.55172 1.000 10.55658 ? 19   GLN A O   1 
ATOM   110  C  CB  . GLN A 1 19  ? -22.69042 24.47504 -29.50635 1.000 11.50686 ? 19   GLN A CB  1 
ATOM   111  C  CG  . GLN A 1 19  ? -23.66268 25.10434 -30.50547 1.000 14.27648 ? 19   GLN A CG  1 
ATOM   112  C  CD  . GLN A 1 19  ? -23.50661 24.56824 -31.92594 1.000 17.73201 ? 19   GLN A CD  1 
ATOM   113  O  OE1 . GLN A 1 19  ? -22.41072 24.17883 -32.35860 1.000 19.17626 ? 19   GLN A OE1 1 
ATOM   114  N  NE2 . GLN A 1 19  ? -24.61462 24.54947 -32.66177 1.000 18.54175 ? 19   GLN A NE2 1 
ATOM   115  N  N   . LEU A 1 20  ? -20.35765 25.24744 -27.17954 1.000 11.87468 ? 20   LEU A N   1 
ATOM   116  C  CA  . LEU A 1 20  ? -19.47378 24.75927 -26.12633 1.000 14.24927 ? 20   LEU A CA  1 
ATOM   117  C  C   . LEU A 1 20  ? -19.93900 23.40831 -25.59178 1.000 11.48642 ? 20   LEU A C   1 
ATOM   118  O  O   . LEU A 1 20  ? -19.13494 22.48085 -25.42904 1.000 12.94244 ? 20   LEU A O   1 
ATOM   119  C  CB  . LEU A 1 20  ? -19.40250 25.80016 -25.00475 1.000 10.12984 ? 20   LEU A CB  1 
ATOM   120  C  CG  . LEU A 1 20  ? -18.19753 25.80070 -24.07247 1.000 16.58592 ? 20   LEU A CG  1 
ATOM   121  C  CD1 . LEU A 1 20  ? -16.87892 25.77460 -24.83917 1.000 15.63308 ? 20   LEU A CD1 1 
ATOM   122  C  CD2 . LEU A 1 20  ? -18.24912 27.01204 -23.15113 1.000 14.78099 ? 20   LEU A CD2 1 
ATOM   123  N  N   . ASP A 1 21  ? -21.23547 23.27395 -25.30340 1.000 10.36366 ? 21   ASP A N   1 
ATOM   124  C  CA  . ASP A 1 21  ? -21.71313 22.01765 -24.72922 1.000 9.77633  ? 21   ASP A CA  1 
ATOM   125  C  C   . ASP A 1 21  ? -21.50402 20.84202 -25.69051 1.000 13.91170 ? 21   ASP A C   1 
ATOM   126  O  O   . ASP A 1 21  ? -21.16029 19.72895 -25.25921 1.000 11.66482 ? 21   ASP A O   1 
ATOM   127  C  CB  . ASP A 1 21  ? -23.18192 22.14781 -24.29065 1.000 9.58824  ? 21   ASP A CB  1 
ATOM   128  C  CG  . ASP A 1 21  ? -24.14697 22.44832 -25.44224 1.000 13.13922 ? 21   ASP A CG  1 
ATOM   129  O  OD1 . ASP A 1 21  ? -23.72293 22.97774 -26.48404 1.000 11.39679 ? 21   ASP A OD1 1 
ATOM   130  O  OD2 . ASP A 1 21  ? -25.36118 22.15920 -25.28681 1.000 14.01520 ? 21   ASP A OD2 1 
ATOM   131  N  N   . GLN A 1 22  ? -21.67122 21.07114 -26.99719 1.000 11.02226 ? 22   GLN A N   1 
ATOM   132  C  CA  . GLN A 1 22  ? -21.49838 19.97879 -27.95277 1.000 13.73962 ? 22   GLN A CA  1 
ATOM   133  C  C   . GLN A 1 22  ? -20.04216 19.56439 -28.05888 1.000 11.18035 ? 22   GLN A C   1 
ATOM   134  O  O   . GLN A 1 22  ? -19.75469 18.38219 -28.25604 1.000 11.70830 ? 22   GLN A O   1 
ATOM   135  C  CB  . GLN A 1 22  ? -22.06208 20.36626 -29.32913 1.000 10.43164 ? 22   GLN A CB  1 
ATOM   136  C  CG  . GLN A 1 22  ? -23.59562 20.45613 -29.31060 1.000 15.85452 ? 22   GLN A CG  1 
ATOM   137  C  CD  . GLN A 1 22  ? -24.19023 20.91714 -30.62711 1.000 19.74950 ? 22   GLN A CD  1 
ATOM   138  O  OE1 . GLN A 1 22  ? -23.69205 20.57725 -31.70078 1.000 20.03403 ? 22   GLN A OE1 1 
ATOM   139  N  NE2 . GLN A 1 22  ? -25.25287 21.71524 -30.54831 1.000 21.10215 ? 22   GLN A NE2 1 
ATOM   140  N  N   . ARG A 1 23  ? -19.11616 20.50586 -27.89114 1.000 10.74212 ? 23   ARG A N   1 
ATOM   141  C  CA  . ARG A 1 23  ? -17.70196 20.15101 -27.90090 1.000 15.19665 ? 23   ARG A CA  1 
ATOM   142  C  C   . ARG A 1 23  ? -17.37259 19.20033 -26.76307 1.000 13.12518 ? 23   ARG A C   1 
ATOM   143  O  O   . ARG A 1 23  ? -16.52112 18.32151 -26.91920 1.000 13.89172 ? 23   ARG A O   1 
ATOM   144  C  CB  . ARG A 1 23  ? -16.84069 21.41850 -27.82482 1.000 12.10319 ? 23   ARG A CB  1 
ATOM   145  C  CG  . ARG A 1 23  ? -15.39173 21.21163 -27.34979 1.000 10.06570 ? 23   ARG A CG  1 
ATOM   146  C  CD  . ARG A 1 23  ? -14.54780 20.42700 -28.34750 1.000 13.36147 ? 23   ARG A CD  1 
ATOM   147  N  NE  . ARG A 1 23  ? -13.15368 20.35341 -27.92221 1.000 12.16165 ? 23   ARG A NE  1 
ATOM   148  C  CZ  . ARG A 1 23  ? -12.70200 19.47583 -27.03561 1.000 16.10055 ? 23   ARG A CZ  1 
ATOM   149  N  NH1 . ARG A 1 23  ? -13.54086 18.60706 -26.48815 1.000 13.05807 ? 23   ARG A NH1 1 
ATOM   150  N  NH2 . ARG A 1 23  ? -11.42035 19.46820 -26.69262 1.000 16.20092 ? 23   ARG A NH2 1 
ATOM   151  N  N   . TYR A 1 24  ? -18.05925 19.32944 -25.62520 1.000 9.61897  ? 24   TYR A N   1 
ATOM   152  C  CA  . TYR A 1 24  ? -17.72211 18.54530 -24.44422 1.000 10.39276 ? 24   TYR A CA  1 
ATOM   153  C  C   . TYR A 1 24  ? -18.75192 17.47259 -24.11216 1.000 11.45438 ? 24   TYR A C   1 
ATOM   154  O  O   . TYR A 1 24  ? -18.67846 16.88635 -23.03244 1.000 11.21261 ? 24   TYR A O   1 
ATOM   155  C  CB  . TYR A 1 24  ? -17.52141 19.48046 -23.24558 1.000 10.25872 ? 24   TYR A CB  1 
ATOM   156  C  CG  . TYR A 1 24  ? -16.21552 20.21818 -23.36998 1.000 12.71676 ? 24   TYR A CG  1 
ATOM   157  C  CD1 . TYR A 1 24  ? -15.01586 19.56065 -23.11459 1.000 14.48452 ? 24   TYR A CD1 1 
ATOM   158  C  CD2 . TYR A 1 24  ? -16.16675 21.55063 -23.79416 1.000 11.95728 ? 24   TYR A CD2 1 
ATOM   159  C  CE1 . TYR A 1 24  ? -13.79639 20.19856 -23.25001 1.000 14.23135 ? 24   TYR A CE1 1 
ATOM   160  C  CE2 . TYR A 1 24  ? -14.93732 22.20783 -23.93276 1.000 10.76814 ? 24   TYR A CE2 1 
ATOM   161  C  CZ  . TYR A 1 24  ? -13.75477 21.51409 -23.66222 1.000 12.68760 ? 24   TYR A CZ  1 
ATOM   162  O  OH  . TYR A 1 24  ? -12.51441 22.11281 -23.78609 1.000 11.19760 ? 24   TYR A OH  1 
ATOM   163  N  N   . LYS A 1 25  ? -19.67191 17.16244 -25.02881 1.000 14.38259 ? 25   LYS A N   1 
ATOM   164  C  CA  . LYS A 1 25  ? -20.89005 16.44781 -24.63886 1.000 20.00401 ? 25   LYS A CA  1 
ATOM   165  C  C   . LYS A 1 25  ? -20.64338 15.01586 -24.16555 1.000 18.21679 ? 25   LYS A C   1 
ATOM   166  O  O   . LYS A 1 25  ? -21.47037 14.48589 -23.41822 1.000 18.33353 ? 25   LYS A O   1 
ATOM   167  C  CB  . LYS A 1 25  ? -21.89458 16.44222 -25.78898 1.000 19.03750 ? 25   LYS A CB  1 
ATOM   168  C  CG  . LYS A 1 25  ? -21.48029 15.64240 -27.00874 1.000 21.90007 ? 25   LYS A CG  1 
ATOM   169  C  CD  . LYS A 1 25  ? -22.64152 15.58861 -27.99878 1.000 25.36608 ? 25   LYS A CD  1 
ATOM   170  C  CE  . LYS A 1 25  ? -22.19607 15.17652 -29.38603 1.000 27.60434 ? 25   LYS A CE  1 
ATOM   171  N  NZ  . LYS A 1 25  ? -21.27576 16.17652 -29.99131 1.000 26.13430 ? 25   LYS A NZ  1 
ATOM   172  N  N   . ASN A 1 26  ? -19.54042 14.37945 -24.56225 1.000 14.95937 ? 26   ASN A N   1 
ATOM   173  C  CA  . ASN A 1 26  ? -19.22843 13.04255 -24.05828 1.000 15.53815 ? 26   ASN A CA  1 
ATOM   174  C  C   . ASN A 1 26  ? -18.34887 13.07480 -22.81641 1.000 17.70468 ? 26   ASN A C   1 
ATOM   175  O  O   . ASN A 1 26  ? -18.16510 12.03132 -22.17375 1.000 14.34636 ? 26   ASN A O   1 
ATOM   176  C  CB  . ASN A 1 26  ? -18.55174 12.20087 -25.15492 1.000 14.35431 ? 26   ASN A CB  1 
ATOM   177  C  CG  . ASN A 1 26  ? -19.42511 12.05101 -26.39364 1.000 20.85802 ? 26   ASN A CG  1 
ATOM   178  O  OD1 . ASN A 1 26  ? -20.63590 11.81287 -26.29500 1.000 20.16157 ? 26   ASN A OD1 1 
ATOM   179  N  ND2 . ASN A 1 26  ? -18.82076 12.20326 -27.56399 1.000 18.26849 ? 26   ASN A ND2 1 
ATOM   180  N  N   . GLU A 1 27  ? -17.81672 14.24434 -22.45532 1.000 12.74229 ? 27   GLU A N   1 
ATOM   181  C  CA  . GLU A 1 27  ? -16.91850 14.39300 -21.31494 1.000 14.41580 ? 27   GLU A CA  1 
ATOM   182  C  C   . GLU A 1 27  ? -17.63314 14.87189 -20.05249 1.000 15.79148 ? 27   GLU A C   1 
ATOM   183  O  O   . GLU A 1 27  ? -17.44985 14.28094 -18.98147 1.000 17.95220 ? 27   GLU A O   1 
ATOM   184  C  CB  . GLU A 1 27  ? -15.78233 15.35592 -21.66751 1.000 13.43504 ? 27   GLU A CB  1 
ATOM   185  C  CG  . GLU A 1 27  ? -15.40354 15.36085 -23.16072 1.000 13.60984 ? 27   GLU A CG  1 
ATOM   186  C  CD  . GLU A 1 27  ? -15.03220 13.97223 -23.68358 1.000 16.44633 ? 27   GLU A CD  1 
ATOM   187  O  OE1 . GLU A 1 27  ? -14.53556 13.13096 -22.89761 1.000 12.67970 ? 27   GLU A OE1 1 
ATOM   188  O  OE2 . GLU A 1 27  ? -15.25128 13.72724 -24.88156 1.000 15.94296 ? 27   GLU A OE2 1 
ATOM   189  N  N   . PHE A 1 28  ? -18.43105 15.93800 -20.15672 1.000 13.10847 ? 28   PHE A N   1 
ATOM   190  C  CA  . PHE A 1 28  ? -19.19874 16.49961 -19.04897 1.000 11.75655 ? 28   PHE A CA  1 
ATOM   191  C  C   . PHE A 1 28  ? -20.16856 17.53069 -19.61294 1.000 14.19854 ? 28   PHE A C   1 
ATOM   192  O  O   . PHE A 1 28  ? -19.95852 18.06610 -20.70523 1.000 14.48165 ? 28   PHE A O   1 
ATOM   193  C  CB  . PHE A 1 28  ? -18.28553 17.13821 -17.98662 1.000 11.26361 ? 28   PHE A CB  1 
ATOM   194  C  CG  . PHE A 1 28  ? -17.00584 17.71798 -18.54633 1.000 11.91477 ? 28   PHE A CG  1 
ATOM   195  C  CD1 . PHE A 1 28  ? -17.01896 18.92824 -19.23287 1.000 11.04539 ? 28   PHE A CD1 1 
ATOM   196  C  CD2 . PHE A 1 28  ? -15.79586 17.07134 -18.36526 1.000 12.18801 ? 28   PHE A CD2 1 
ATOM   197  C  CE1 . PHE A 1 28  ? -15.85132 19.47850 -19.73531 1.000 13.50776 ? 28   PHE A CE1 1 
ATOM   198  C  CE2 . PHE A 1 28  ? -14.60820 17.60390 -18.87220 1.000 12.96303 ? 28   PHE A CE2 1 
ATOM   199  C  CZ  . PHE A 1 28  ? -14.63010 18.81019 -19.55534 1.000 12.17098 ? 28   PHE A CZ  1 
ATOM   200  N  N   . THR A 1 29  ? -21.24373 17.79129 -18.87050 1.000 11.66946 ? 29   THR A N   1 
ATOM   201  C  CA  . THR A 1 29  ? -22.12805 18.87896 -19.25591 1.000 12.25836 ? 29   THR A CA  1 
ATOM   202  C  C   . THR A 1 29  ? -21.42651 20.21860 -19.02499 1.000 10.65841 ? 29   THR A C   1 
ATOM   203  O  O   . THR A 1 29  ? -20.43153 20.31456 -18.30520 1.000 10.87963 ? 29   THR A O   1 
ATOM   204  C  CB  . THR A 1 29  ? -23.44842 18.83075 -18.47059 1.000 12.07007 ? 29   THR A CB  1 
ATOM   205  O  OG1 . THR A 1 29  ? -23.17413 18.82168 -17.06786 1.000 12.36502 ? 29   THR A OG1 1 
ATOM   206  C  CG2 . THR A 1 29  ? -24.24756 17.57687 -18.82326 1.000 17.13059 ? 29   THR A CG2 1 
ATOM   207  N  N   . ILE A 1 30  ? -21.95415 21.26134 -19.66137 1.000 10.98528 ? 30   ILE A N   1 
ATOM   208  C  CA  . ILE A 1 30  ? -21.41399 22.61498 -19.55812 1.000 9.33681  ? 30   ILE A CA  1 
ATOM   209  C  C   . ILE A 1 30  ? -22.54337 23.51943 -19.06374 1.000 7.92688  ? 30   ILE A C   1 
ATOM   210  O  O   . ILE A 1 30  ? -23.55569 23.68864 -19.75740 1.000 10.02234 ? 30   ILE A O   1 
ATOM   211  C  CB  . ILE A 1 30  ? -20.85039 23.11226 -20.90470 1.000 7.77340  ? 30   ILE A CB  1 
ATOM   212  C  CG1 . ILE A 1 30  ? -19.67302 22.24563 -21.38643 1.000 10.66210 ? 30   ILE A CG1 1 
ATOM   213  C  CG2 . ILE A 1 30  ? -20.43138 24.59496 -20.82265 1.000 8.74235  ? 30   ILE A CG2 1 
ATOM   214  C  CD1 . ILE A 1 30  ? -18.38879 22.35224 -20.56176 1.000 8.47061  ? 30   ILE A CD1 1 
ATOM   215  N  N   . GLY A 1 31  ? -22.36553 24.10351 -17.87632 1.000 8.10664  ? 31   GLY A N   1 
ATOM   216  C  CA  . GLY A 1 31  ? -23.40878 24.86957 -17.22994 1.000 8.86495  ? 31   GLY A CA  1 
ATOM   217  C  C   . GLY A 1 31  ? -23.05951 26.33954 -17.06147 1.000 11.00107 ? 31   GLY A C   1 
ATOM   218  O  O   . GLY A 1 31  ? -21.89779 26.75773 -17.16998 1.000 10.21863 ? 31   GLY A O   1 
ATOM   219  N  N   . ALA A 1 32  ? -24.10172 27.12580 -16.78712 1.000 7.83531  ? 32   ALA A N   1 
ATOM   220  C  CA  . ALA A 1 32  ? -23.99739 28.54771 -16.50524 1.000 10.77046 ? 32   ALA A CA  1 
ATOM   221  C  C   . ALA A 1 32  ? -24.89660 28.88637 -15.32642 1.000 10.59167 ? 32   ALA A C   1 
ATOM   222  O  O   . ALA A 1 32  ? -25.98865 28.32601 -15.19288 1.000 9.08761  ? 32   ALA A O   1 
ATOM   223  C  CB  . ALA A 1 32  ? -24.40317 29.39354 -17.72584 1.000 8.54327  ? 32   ALA A CB  1 
ATOM   224  N  N   . ALA A 1 33  ? -24.44025 29.81207 -14.47804 1.000 11.19365 ? 33   ALA A N   1 
ATOM   225  C  CA  . ALA A 1 33  ? -25.25303 30.35065 -13.38875 1.000 8.74285  ? 33   ALA A CA  1 
ATOM   226  C  C   . ALA A 1 33  ? -26.00366 31.59119 -13.86479 1.000 9.96090  ? 33   ALA A C   1 
ATOM   227  O  O   . ALA A 1 33  ? -25.43378 32.44473 -14.55956 1.000 9.54777  ? 33   ALA A O   1 
ATOM   228  C  CB  . ALA A 1 33  ? -24.36675 30.69438 -12.18313 1.000 9.52912  ? 33   ALA A CB  1 
ATOM   229  N  N   . VAL A 1 34  ? -27.28438 31.69873 -13.47601 1.000 9.68005  ? 34   VAL A N   1 
ATOM   230  C  CA  . VAL A 1 34  ? -28.17748 32.71775 -14.02281 1.000 9.62757  ? 34   VAL A CA  1 
ATOM   231  C  C   . VAL A 1 34  ? -29.05572 33.35677 -12.94260 1.000 10.81762 ? 34   VAL A C   1 
ATOM   232  O  O   . VAL A 1 34  ? -29.26659 32.81509 -11.85261 1.000 11.16981 ? 34   VAL A O   1 
ATOM   233  C  CB  . VAL A 1 34  ? -29.08863 32.16190 -15.14884 1.000 11.22149 ? 34   VAL A CB  1 
ATOM   234  C  CG1 . VAL A 1 34  ? -28.28518 31.34070 -16.17556 1.000 7.02011  ? 34   VAL A CG1 1 
ATOM   235  C  CG2 . VAL A 1 34  ? -30.23054 31.34368 -14.57572 1.000 9.70482  ? 34   VAL A CG2 1 
ATOM   236  N  N   . GLU A 1 35  ? -29.55541 34.54996 -13.26934 1.000 9.53393  ? 35   GLU A N   1 
ATOM   237  C  CA  . GLU A 1 35  ? -30.61639 35.25763 -12.58895 1.000 11.73462 ? 35   GLU A CA  1 
ATOM   238  C  C   . GLU A 1 35  ? -31.85744 35.24811 -13.47227 1.000 10.80634 ? 35   GLU A C   1 
ATOM   239  O  O   . GLU A 1 35  ? -31.74576 35.26997 -14.70513 1.000 13.18687 ? 35   GLU A O   1 
ATOM   240  C  CB  . GLU A 1 35  ? -30.24266 36.71646 -12.28001 1.000 12.55824 ? 35   GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 35  ? -29.05862 36.88649 -11.35399 1.000 13.58461 ? 35   GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 35  ? -29.45069 36.84495 -9.88473  1.000 16.09419 ? 35   GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 35  ? -30.46874 36.18836 -9.54036  1.000 11.74226 ? 35   GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 35  ? -28.72644 37.46509 -9.07396  1.000 16.01002 ? 35   GLU A OE2 1 
ATOM   245  N  N   . PRO A 1 36  ? -33.05059 35.20705 -12.88268 1.000 14.64748 ? 36   PRO A N   1 
ATOM   246  C  CA  . PRO A 1 36  ? -34.26238 35.12740 -13.71514 1.000 13.50480 ? 36   PRO A CA  1 
ATOM   247  C  C   . PRO A 1 36  ? -34.34724 36.21848 -14.77458 1.000 14.20674 ? 36   PRO A C   1 
ATOM   248  O  O   . PRO A 1 36  ? -34.83925 35.95302 -15.87985 1.000 15.06060 ? 36   PRO A O   1 
ATOM   249  C  CB  . PRO A 1 36  ? -35.39665 35.22861 -12.68004 1.000 18.38039 ? 36   PRO A CB  1 
ATOM   250  C  CG  . PRO A 1 36  ? -34.80672 34.58523 -11.44574 1.000 16.34070 ? 36   PRO A CG  1 
ATOM   251  C  CD  . PRO A 1 36  ? -33.35124 35.05547 -11.44560 1.000 12.24806 ? 36   PRO A CD  1 
ATOM   252  N  N   . TYR A 1 37  ? -33.85590 37.42998 -14.49648 1.000 15.15993 ? 37   TYR A N   1 
ATOM   253  C  CA  . TYR A 1 37  ? -34.00745 38.50028 -15.48125 1.000 19.28252 ? 37   TYR A CA  1 
ATOM   254  C  C   . TYR A 1 37  ? -33.25512 38.18853 -16.77106 1.000 17.46865 ? 37   TYR A C   1 
ATOM   255  O  O   . TYR A 1 37  ? -33.68283 38.60385 -17.85021 1.000 16.69009 ? 37   TYR A O   1 
ATOM   256  C  CB  . TYR A 1 37  ? -33.55843 39.84113 -14.88880 1.000 19.92335 ? 37   TYR A CB  1 
ATOM   257  C  CG  . TYR A 1 37  ? -32.06325 40.07013 -14.89249 1.000 20.22105 ? 37   TYR A CG  1 
ATOM   258  C  CD1 . TYR A 1 37  ? -31.40957 40.49428 -16.03894 1.000 19.85692 ? 37   TYR A CD1 1 
ATOM   259  C  CD2 . TYR A 1 37  ? -31.30933 39.87321 -13.74092 1.000 21.83218 ? 37   TYR A CD2 1 
ATOM   260  C  CE1 . TYR A 1 37  ? -30.06059 40.69814 -16.05341 1.000 22.14684 ? 37   TYR A CE1 1 
ATOM   261  C  CE2 . TYR A 1 37  ? -29.95174 40.08837 -13.74148 1.000 20.67536 ? 37   TYR A CE2 1 
ATOM   262  C  CZ  . TYR A 1 37  ? -29.33041 40.49644 -14.90217 1.000 23.17139 ? 37   TYR A CZ  1 
ATOM   263  O  OH  . TYR A 1 37  ? -27.97249 40.71869 -14.93403 1.000 27.12363 ? 37   TYR A OH  1 
ATOM   264  N  N   . GLN A 1 38  ? -32.15226 37.44114 -16.68699 1.000 14.88330 ? 38   GLN A N   1 
ATOM   265  C  CA  . GLN A 1 38  ? -31.43021 37.05950 -17.89892 1.000 13.11662 ? 38   GLN A CA  1 
ATOM   266  C  C   . GLN A 1 38  ? -32.28712 36.20069 -18.82278 1.000 16.94970 ? 38   GLN A C   1 
ATOM   267  O  O   . GLN A 1 38  ? -32.05416 36.16887 -20.03539 1.000 17.82026 ? 38   GLN A O   1 
ATOM   268  C  CB  . GLN A 1 38  ? -30.13520 36.33846 -17.51795 1.000 11.56711 ? 38   GLN A CB  1 
ATOM   269  C  CG  . GLN A 1 38  ? -29.16844 37.25043 -16.76464 1.000 11.59442 ? 38   GLN A CG  1 
ATOM   270  C  CD  . GLN A 1 38  ? -28.00257 36.50211 -16.16432 1.000 13.76167 ? 38   GLN A CD  1 
ATOM   271  O  OE1 . GLN A 1 38  ? -28.16656 35.42341 -15.59762 1.000 15.85995 ? 38   GLN A OE1 1 
ATOM   272  N  NE2 . GLN A 1 38  ? -26.82089 37.06593 -16.28563 1.000 8.90622  ? 38   GLN A NE2 1 
ATOM   273  N  N   . LEU A 1 39  ? -33.29292 35.51669 -18.28236 1.000 14.58409 ? 39   LEU A N   1 
ATOM   274  C  CA  . LEU A 1 39  ? -34.20320 34.73135 -19.11443 1.000 16.78569 ? 39   LEU A CA  1 
ATOM   275  C  C   . LEU A 1 39  ? -35.17725 35.59987 -19.89768 1.000 17.48419 ? 39   LEU A C   1 
ATOM   276  O  O   . LEU A 1 39  ? -35.89879 35.08018 -20.75783 1.000 23.01594 ? 39   LEU A O   1 
ATOM   277  C  CB  . LEU A 1 39  ? -34.98759 33.74058 -18.24631 1.000 14.35826 ? 39   LEU A CB  1 
ATOM   278  C  CG  . LEU A 1 39  ? -34.13574 32.84258 -17.35262 1.000 15.64355 ? 39   LEU A CG  1 
ATOM   279  C  CD1 . LEU A 1 39  ? -35.00369 31.86570 -16.55877 1.000 15.38275 ? 39   LEU A CD1 1 
ATOM   280  C  CD2 . LEU A 1 39  ? -33.07004 32.10097 -18.17213 1.000 13.24227 ? 39   LEU A CD2 1 
ATOM   281  N  N   . GLN A 1 40  ? -35.22939 36.89625 -19.61178 1.000 19.54491 ? 40   GLN A N   1 
ATOM   282  C  CA  . GLN A 1 40  ? -36.04817 37.82943 -20.36984 1.000 24.73318 ? 40   GLN A CA  1 
ATOM   283  C  C   . GLN A 1 40  ? -35.19597 38.69904 -21.27860 1.000 23.33519 ? 40   GLN A C   1 
ATOM   284  O  O   . GLN A 1 40  ? -35.69016 39.67993 -21.83770 1.000 23.39491 ? 40   GLN A O   1 
ATOM   285  C  CB  . GLN A 1 40  ? -36.88539 38.69524 -19.42510 1.000 25.87951 ? 40   GLN A CB  1 
ATOM   286  C  CG  . GLN A 1 40  ? -37.82958 37.89844 -18.53110 1.000 24.11382 ? 40   GLN A CG  1 
ATOM   287  C  CD  . GLN A 1 40  ? -38.69637 36.91757 -19.31714 1.000 39.28650 ? 40   GLN A CD  1 
ATOM   288  O  OE1 . GLN A 1 40  ? -38.76745 35.72799 -18.98877 1.000 42.65958 ? 40   GLN A OE1 1 
ATOM   289  N  NE2 . GLN A 1 40  ? -39.35803 37.41255 -20.36176 1.000 34.73515 ? 40   GLN A NE2 1 
ATOM   290  N  N   . ASN A 1 41  ? -33.92500 38.35717 -21.43232 1.000 21.10441 ? 41   ASN A N   1 
ATOM   291  C  CA  . ASN A 1 41  ? -32.99679 39.09312 -22.27072 1.000 19.88983 ? 41   ASN A CA  1 
ATOM   292  C  C   . ASN A 1 41  ? -32.62325 38.23343 -23.47145 1.000 24.38806 ? 41   ASN A C   1 
ATOM   293  O  O   . ASN A 1 41  ? -32.18353 37.09113 -23.30144 1.000 19.08648 ? 41   ASN A O   1 
ATOM   294  C  CB  . ASN A 1 41  ? -31.75088 39.46253 -21.46955 1.000 23.98998 ? 41   ASN A CB  1 
ATOM   295  C  CG  . ASN A 1 41  ? -30.69846 40.08357 -22.32342 1.000 34.05953 ? 41   ASN A CG  1 
ATOM   296  O  OD1 . ASN A 1 41  ? -29.83400 39.38886 -22.87166 1.000 30.62593 ? 41   ASN A OD1 1 
ATOM   297  N  ND2 . ASN A 1 41  ? -30.77666 41.40452 -22.48463 1.000 40.79454 ? 41   ASN A ND2 1 
ATOM   298  N  N   . GLU A 1 42  ? -32.76769 38.79137 -24.67888 1.000 21.06211 ? 42   GLU A N   1 
ATOM   299  C  CA  . GLU A 1 42  ? -32.63044 37.97230 -25.87877 1.000 22.41040 ? 42   GLU A CA  1 
ATOM   300  C  C   . GLU A 1 42  ? -31.23692 37.36930 -25.99617 1.000 19.19303 ? 42   GLU A C   1 
ATOM   301  O  O   . GLU A 1 42  ? -31.09961 36.18003 -26.30401 1.000 19.06897 ? 42   GLU A O   1 
ATOM   302  C  CB  . GLU A 1 42  ? -32.96027 38.77708 -27.13545 1.000 24.45300 ? 42   GLU A CB  1 
ATOM   303  C  CG  . GLU A 1 42  ? -32.93294 37.91002 -28.39382 1.000 42.93469 ? 42   GLU A CG  1 
ATOM   304  C  CD  . GLU A 1 42  ? -33.31689 38.65406 -29.66970 1.000 60.17850 ? 42   GLU A CD  1 
ATOM   305  O  OE1 . GLU A 1 42  ? -32.61402 39.62138 -30.04778 1.000 55.51695 ? 42   GLU A OE1 1 
ATOM   306  O  OE2 . GLU A 1 42  ? -34.32412 38.25946 -30.29955 1.000 63.92636 ? 42   GLU A OE2 1 
ATOM   307  N  N   . LYS A 1 43  ? -30.18844 38.16348 -25.76626 1.000 14.42451 ? 43   LYS A N   1 
ATOM   308  C  CA  . LYS A 1 43  ? -28.84291 37.62488 -25.93876 1.000 16.80999 ? 43   LYS A CA  1 
ATOM   309  C  C   . LYS A 1 43  ? -28.54052 36.53882 -24.90923 1.000 15.13133 ? 43   LYS A C   1 
ATOM   310  O  O   . LYS A 1 43  ? -27.95448 35.50517 -25.24333 1.000 16.88333 ? 43   LYS A O   1 
ATOM   311  C  CB  . LYS A 1 43  ? -27.79057 38.73543 -25.87274 1.000 17.78434 ? 43   LYS A CB  1 
ATOM   312  C  CG  . LYS A 1 43  ? -27.99942 39.84285 -26.90892 1.000 31.27678 ? 43   LYS A CG  1 
ATOM   313  C  CD  . LYS A 1 43  ? -26.67277 40.51514 -27.28128 1.000 37.02890 ? 43   LYS A CD  1 
ATOM   314  C  CE  . LYS A 1 43  ? -25.80907 39.56399 -28.12372 1.000 35.69950 ? 43   LYS A CE  1 
ATOM   315  N  NZ  . LYS A 1 43  ? -26.12388 39.57585 -29.59202 1.000 39.13176 ? 43   LYS A NZ  1 
ATOM   316  N  N   . ASP A 1 44  ? -28.91819 36.75147 -23.64485 1.000 13.12277 ? 44   ASP A N   1 
ATOM   317  C  CA  . ASP A 1 44  ? -28.65426 35.72440 -22.63601 1.000 16.13305 ? 44   ASP A CA  1 
ATOM   318  C  C   . ASP A 1 44  ? -29.42228 34.45509 -22.95266 1.000 12.46830 ? 44   ASP A C   1 
ATOM   319  O  O   . ASP A 1 44  ? -28.88266 33.35135 -22.83109 1.000 13.92255 ? 44   ASP A O   1 
ATOM   320  C  CB  . ASP A 1 44  ? -29.00408 36.22789 -21.23055 1.000 15.90032 ? 44   ASP A CB  1 
ATOM   321  C  CG  . ASP A 1 44  ? -28.00314 37.23410 -20.72396 1.000 15.43576 ? 44   ASP A CG  1 
ATOM   322  O  OD1 . ASP A 1 44  ? -26.81484 37.13891 -21.10629 1.000 13.33497 ? 44   ASP A OD1 1 
ATOM   323  O  OD2 . ASP A 1 44  ? -28.41099 38.12963 -19.96533 1.000 16.43193 ? 44   ASP A OD2 1 
ATOM   324  N  N   . VAL A 1 45  ? -30.67319 34.59008 -23.38931 1.000 11.76009 ? 45   VAL A N   1 
ATOM   325  C  CA  . VAL A 1 45  ? -31.44793 33.40607 -23.74666 1.000 12.51900 ? 45   VAL A CA  1 
ATOM   326  C  C   . VAL A 1 45  ? -30.77470 32.64580 -24.88258 1.000 14.26749 ? 45   VAL A C   1 
ATOM   327  O  O   . VAL A 1 45  ? -30.66676 31.41360 -24.85207 1.000 12.17317 ? 45   VAL A O   1 
ATOM   328  C  CB  . VAL A 1 45  ? -32.88371 33.80650 -24.11504 1.000 14.21136 ? 45   VAL A CB  1 
ATOM   329  C  CG1 . VAL A 1 45  ? -33.57033 32.65592 -24.84242 1.000 11.79899 ? 45   VAL A CG1 1 
ATOM   330  C  CG2 . VAL A 1 45  ? -33.63738 34.21147 -22.85955 1.000 14.83160 ? 45   VAL A CG2 1 
ATOM   331  N  N   . GLN A 1 46  ? -30.31867 33.36183 -25.90533 1.000 15.31510 ? 46   GLN A N   1 
ATOM   332  C  CA  . GLN A 1 46  ? -29.66955 32.68715 -27.02505 1.000 16.75551 ? 46   GLN A CA  1 
ATOM   333  C  C   . GLN A 1 46  ? -28.34230 32.06059 -26.61372 1.000 12.35508 ? 46   GLN A C   1 
ATOM   334  O  O   . GLN A 1 46  ? -27.99347 30.98253 -27.10750 1.000 12.39627 ? 46   GLN A O   1 
ATOM   335  C  CB  . GLN A 1 46  ? -29.48294 33.66443 -28.18746 1.000 15.08533 ? 46   GLN A CB  1 
ATOM   336  C  CG  . GLN A 1 46  ? -30.82209 34.11399 -28.79167 1.000 28.61240 ? 46   GLN A CG  1 
ATOM   337  C  CD  . GLN A 1 46  ? -31.73904 32.94189 -29.19592 1.000 38.52364 ? 46   GLN A CD  1 
ATOM   338  O  OE1 . GLN A 1 46  ? -31.29593 31.97206 -29.82098 1.000 35.32081 ? 46   GLN A OE1 1 
ATOM   339  N  NE2 . GLN A 1 46  ? -33.02560 33.03475 -28.83111 1.000 33.48596 ? 46   GLN A NE2 1 
ATOM   340  N  N   . MET A 1 47  ? -27.60631 32.70231 -25.70589 1.000 10.74981 ? 47   MET A N   1 
ATOM   341  C  CA  . MET A 1 47  ? -26.37355 32.11361 -25.19676 1.000 10.21800 ? 47   MET A CA  1 
ATOM   342  C  C   . MET A 1 47  ? -26.65018 30.78555 -24.49320 1.000 11.98131 ? 47   MET A C   1 
ATOM   343  O  O   . MET A 1 47  ? -25.95404 29.78707 -24.72327 1.000 10.58726 ? 47   MET A O   1 
ATOM   344  C  CB  . MET A 1 47  ? -25.68445 33.09797 -24.25018 1.000 9.92679  ? 47   MET A CB  1 
ATOM   345  C  CG  . MET A 1 47  ? -25.01652 34.28768 -24.95286 1.000 10.94779 ? 47   MET A CG  1 
ATOM   346  S  SD  . MET A 1 47  ? -23.57215 33.81949 -25.95341 1.000 12.88679 ? 47   MET A SD  1 
ATOM   347  C  CE  . MET A 1 47  ? -22.42871 33.31651 -24.66944 1.000 8.92383  ? 47   MET A CE  1 
ATOM   348  N  N   . LEU A 1 48  ? -27.67250 30.75323 -23.63187 1.000 10.05409 ? 48   LEU A N   1 
ATOM   349  C  CA  . LEU A 1 48  ? -27.98290 29.52143 -22.91008 1.000 11.20775 ? 48   LEU A CA  1 
ATOM   350  C  C   . LEU A 1 48  ? -28.44503 28.43228 -23.86973 1.000 13.06744 ? 48   LEU A C   1 
ATOM   351  O  O   . LEU A 1 48  ? -28.03517 27.26800 -23.75334 1.000 11.19511 ? 48   LEU A O   1 
ATOM   352  C  CB  . LEU A 1 48  ? -29.05025 29.79377 -21.84281 1.000 14.41307 ? 48   LEU A CB  1 
ATOM   353  C  CG  . LEU A 1 48  ? -28.59061 30.75000 -20.73514 1.000 13.02136 ? 48   LEU A CG  1 
ATOM   354  C  CD1 . LEU A 1 48  ? -29.77943 31.44860 -20.08795 1.000 10.60828 ? 48   LEU A CD1 1 
ATOM   355  C  CD2 . LEU A 1 48  ? -27.72624 30.02601 -19.68576 1.000 8.91433  ? 48   LEU A CD2 1 
ATOM   356  N  N   . LYS A 1 49  ? -29.29276 28.79773 -24.83111 1.000 11.48437 ? 49   LYS A N   1 
ATOM   357  C  CA  . LYS A 1 49  ? -29.77231 27.82193 -25.80618 1.000 14.74527 ? 49   LYS A CA  1 
ATOM   358  C  C   . LYS A 1 49  ? -28.63087 27.28589 -26.65088 1.000 14.15366 ? 49   LYS A C   1 
ATOM   359  O  O   . LYS A 1 49  ? -28.58890 26.09010 -26.95967 1.000 13.56300 ? 49   LYS A O   1 
ATOM   360  C  CB  . LYS A 1 49  ? -30.83126 28.45040 -26.70873 1.000 15.49647 ? 49   LYS A CB  1 
ATOM   361  C  CG  . LYS A 1 49  ? -32.21458 28.49311 -26.10800 1.000 18.64783 ? 49   LYS A CG  1 
ATOM   362  C  CD  . LYS A 1 49  ? -33.17465 29.28283 -26.98753 1.000 20.94934 ? 49   LYS A CD  1 
ATOM   363  C  CE  . LYS A 1 49  ? -34.62511 29.06592 -26.55752 1.000 23.89436 ? 49   LYS A CE  1 
ATOM   364  N  NZ  . LYS A 1 49  ? -35.54825 30.02433 -27.23655 1.000 31.00219 ? 49   LYS A NZ  1 
ATOM   365  N  N   . ARG A 1 50  ? -27.68656 28.15326 -27.02925 1.000 10.20423 ? 50   ARG A N   1 
ATOM   366  C  CA  . ARG A 1 50  ? -26.63958 27.73305 -27.95763 1.000 13.26670 ? 50   ARG A CA  1 
ATOM   367  C  C   . ARG A 1 50  ? -25.51462 26.97522 -27.26712 1.000 14.56724 ? 50   ARG A C   1 
ATOM   368  O  O   . ARG A 1 50  ? -25.00830 25.99256 -27.82131 1.000 11.13603 ? 50   ARG A O   1 
ATOM   369  C  CB  . ARG A 1 50  ? -26.04606 28.92998 -28.70651 1.000 14.50833 ? 50   ARG A CB  1 
ATOM   370  C  CG  . ARG A 1 50  ? -24.97440 28.50777 -29.73133 1.000 17.27797 ? 50   ARG A CG  1 
ATOM   371  C  CD  . ARG A 1 50  ? -24.68192 29.58765 -30.76189 1.000 20.29101 ? 50   ARG A CD  1 
ATOM   372  N  NE  . ARG A 1 50  ? -23.76725 29.13867 -31.81302 1.000 20.47314 ? 50   ARG A NE  1 
ATOM   373  C  CZ  . ARG A 1 50  ? -24.13588 28.44344 -32.88756 1.000 25.40436 ? 50   ARG A CZ  1 
ATOM   374  N  NH1 . ARG A 1 50  ? -25.40740 28.10597 -33.07099 1.000 21.77016 ? 50   ARG A NH1 1 
ATOM   375  N  NH2 . ARG A 1 50  ? -23.23054 28.08990 -33.79079 1.000 21.88405 ? 50   ARG A NH2 1 
ATOM   376  N  N   . HIS A 1 51  ? -25.08273 27.40399 -26.07744 1.000 9.47887  ? 51   HIS A N   1 
ATOM   377  C  CA  . HIS A 1 51  ? -23.80466 26.90598 -25.56986 1.000 9.50926  ? 51   HIS A CA  1 
ATOM   378  C  C   . HIS A 1 51  ? -23.88103 26.00625 -24.34853 1.000 10.46902 ? 51   HIS A C   1 
ATOM   379  O  O   . HIS A 1 51  ? -22.87120 25.36880 -24.02391 1.000 9.88981  ? 51   HIS A O   1 
ATOM   380  C  CB  . HIS A 1 51  ? -22.87432 28.07593 -25.24428 1.000 8.17015  ? 51   HIS A CB  1 
ATOM   381  C  CG  . HIS A 1 51  ? -22.29492 28.71703 -26.45965 1.000 10.89396 ? 51   HIS A CG  1 
ATOM   382  N  ND1 . HIS A 1 51  ? -21.35956 28.08674 -27.25367 1.000 10.34799 ? 51   HIS A ND1 1 
ATOM   383  C  CD2 . HIS A 1 51  ? -22.53229 29.92007 -27.03480 1.000 11.71587 ? 51   HIS A CD2 1 
ATOM   384  C  CE1 . HIS A 1 51  ? -21.03921 28.87836 -28.26174 1.000 12.92661 ? 51   HIS A CE1 1 
ATOM   385  N  NE2 . HIS A 1 51  ? -21.73074 29.99906 -28.14863 1.000 9.07645  ? 51   HIS A NE2 1 
ATOM   386  N  N   . PHE A 1 52  ? -25.01752 25.94154 -23.65568 1.000 9.80255  ? 52   PHE A N   1 
ATOM   387  C  CA  . PHE A 1 52  ? -25.07817 25.34346 -22.32925 1.000 10.15852 ? 52   PHE A CA  1 
ATOM   388  C  C   . PHE A 1 52  ? -26.14075 24.25756 -22.27878 1.000 10.23652 ? 52   PHE A C   1 
ATOM   389  O  O   . PHE A 1 52  ? -27.20482 24.38861 -22.89318 1.000 11.42412 ? 52   PHE A O   1 
ATOM   390  C  CB  . PHE A 1 52  ? -25.35677 26.42309 -21.26452 1.000 10.68179 ? 52   PHE A CB  1 
ATOM   391  C  CG  . PHE A 1 52  ? -24.24341 27.43805 -21.14893 1.000 9.77223  ? 52   PHE A CG  1 
ATOM   392  C  CD1 . PHE A 1 52  ? -23.11130 27.14870 -20.39975 1.000 7.97065  ? 52   PHE A CD1 1 
ATOM   393  C  CD2 . PHE A 1 52  ? -24.32717 28.67050 -21.79496 1.000 7.31562  ? 52   PHE A CD2 1 
ATOM   394  C  CE1 . PHE A 1 52  ? -22.06227 28.07362 -20.31001 1.000 9.11512  ? 52   PHE A CE1 1 
ATOM   395  C  CE2 . PHE A 1 52  ? -23.29348 29.59807 -21.70595 1.000 8.57973  ? 52   PHE A CE2 1 
ATOM   396  C  CZ  . PHE A 1 52  ? -22.16289 29.30221 -20.96733 1.000 8.15362  ? 52   PHE A CZ  1 
ATOM   397  N  N   . ASN A 1 53  ? -25.85153 23.17741 -21.54395 1.000 9.66056  ? 53   ASN A N   1 
ATOM   398  C  CA  . ASN A 1 53  ? -26.86325 22.14677 -21.32330 1.000 9.56089  ? 53   ASN A CA  1 
ATOM   399  C  C   . ASN A 1 53  ? -27.06729 21.87716 -19.83575 1.000 13.39406 ? 53   ASN A C   1 
ATOM   400  O  O   . ASN A 1 53  ? -27.58006 20.81645 -19.46332 1.000 11.88509 ? 53   ASN A O   1 
ATOM   401  C  CB  . ASN A 1 53  ? -26.51289 20.85240 -22.07528 1.000 9.13231  ? 53   ASN A CB  1 
ATOM   402  C  CG  . ASN A 1 53  ? -25.12673 20.33758 -21.74350 1.000 9.65751  ? 53   ASN A CG  1 
ATOM   403  O  OD1 . ASN A 1 53  ? -24.50031 20.79116 -20.79518 1.000 11.18179 ? 53   ASN A OD1 1 
ATOM   404  N  ND2 . ASN A 1 53  ? -24.64215 19.38262 -22.52605 1.000 10.04399 ? 53   ASN A ND2 1 
ATOM   405  N  N   . SER A 1 54  ? -26.67274 22.81885 -18.97767 1.000 10.20129 ? 54   SER A N   1 
ATOM   406  C  CA  . SER A 1 54  ? -26.88736 22.69174 -17.54651 1.000 9.81135  ? 54   SER A CA  1 
ATOM   407  C  C   . SER A 1 54  ? -27.01718 24.10172 -16.99133 1.000 12.91814 ? 54   SER A C   1 
ATOM   408  O  O   . SER A 1 54  ? -26.42876 25.04325 -17.53821 1.000 9.86163  ? 54   SER A O   1 
ATOM   409  C  CB  . SER A 1 54  ? -25.73668 21.91261 -16.87910 1.000 13.41786 ? 54   SER A CB  1 
ATOM   410  O  OG  . SER A 1 54  ? -25.97834 21.74541 -15.48145 1.000 12.56712 ? 54   SER A OG  1 
ATOM   411  N  N   . ILE A 1 55  ? -27.79104 24.25232 -15.90879 1.000 10.49168 ? 55   ILE A N   1 
ATOM   412  C  CA  . ILE A 1 55  ? -28.09350 25.58325 -15.38352 1.000 9.64274  ? 55   ILE A CA  1 
ATOM   413  C  C   . ILE A 1 55  ? -28.15515 25.52964 -13.85805 1.000 10.83341 ? 55   ILE A C   1 
ATOM   414  O  O   . ILE A 1 55  ? -28.46510 24.49184 -13.26219 1.000 13.50421 ? 55   ILE A O   1 
ATOM   415  C  CB  . ILE A 1 55  ? -29.41958 26.14358 -15.97444 1.000 9.04937  ? 55   ILE A CB  1 
ATOM   416  C  CG1 . ILE A 1 55  ? -29.44692 27.67647 -15.92330 1.000 8.53658  ? 55   ILE A CG1 1 
ATOM   417  C  CG2 . ILE A 1 55  ? -30.63834 25.56254 -15.21758 1.000 7.34627  ? 55   ILE A CG2 1 
ATOM   418  C  CD1 . ILE A 1 55  ? -30.56019 28.32054 -16.81566 1.000 8.44605  ? 55   ILE A CD1 1 
ATOM   419  N  N   . VAL A 1 56  ? -27.85713 26.66650 -13.22761 1.000 11.15127 ? 56   VAL A N   1 
ATOM   420  C  CA  . VAL A 1 56  ? -27.94067 26.82309 -11.77624 1.000 10.45021 ? 56   VAL A CA  1 
ATOM   421  C  C   . VAL A 1 56  ? -28.34050 28.27074 -11.49537 1.000 9.77200  ? 56   VAL A C   1 
ATOM   422  O  O   . VAL A 1 56  ? -28.08340 29.16951 -12.30240 1.000 10.60025 ? 56   VAL A O   1 
ATOM   423  C  CB  . VAL A 1 56  ? -26.59671 26.43968 -11.09899 1.000 10.85054 ? 56   VAL A CB  1 
ATOM   424  C  CG1 . VAL A 1 56  ? -25.46379 27.35520 -11.57640 1.000 7.40344  ? 56   VAL A CG1 1 
ATOM   425  C  CG2 . VAL A 1 56  ? -26.68411 26.45318 -9.55937  1.000 11.58843 ? 56   VAL A CG2 1 
ATOM   426  N  N   . ALA A 1 57  ? -28.99010 28.49643 -10.35501 1.000 8.69894  ? 57   ALA A N   1 
ATOM   427  C  CA  . ALA A 1 57  ? -29.35785 29.84110 -9.92335  1.000 8.17187  ? 57   ALA A CA  1 
ATOM   428  C  C   . ALA A 1 57  ? -28.19539 30.50129 -9.18394  1.000 9.43902  ? 57   ALA A C   1 
ATOM   429  O  O   . ALA A 1 57  ? -27.71707 29.97489 -8.17323  1.000 9.98341  ? 57   ALA A O   1 
ATOM   430  C  CB  . ALA A 1 57  ? -30.59645 29.80647 -9.02429  1.000 9.99616  ? 57   ALA A CB  1 
ATOM   431  N  N   . GLU A 1 58  ? -27.76238 31.66677 -9.67913  1.000 9.47185  ? 58   GLU A N   1 
ATOM   432  C  CA  . GLU A 1 58  ? -26.83656 32.51188 -8.92998  1.000 11.78183 ? 58   GLU A CA  1 
ATOM   433  C  C   . GLU A 1 58  ? -27.31103 32.75612 -7.50363  1.000 14.25456 ? 58   GLU A C   1 
ATOM   434  O  O   . GLU A 1 58  ? -26.51241 32.70598 -6.56003  1.000 13.80426 ? 58   GLU A O   1 
ATOM   435  C  CB  . GLU A 1 58  ? -26.67575 33.86200 -9.62645  1.000 11.03666 ? 58   GLU A CB  1 
ATOM   436  C  CG  . GLU A 1 58  ? -25.60622 33.94685 -10.68916 1.000 13.01494 ? 58   GLU A CG  1 
ATOM   437  C  CD  . GLU A 1 58  ? -25.31359 35.39226 -11.04558 1.000 15.67328 ? 58   GLU A CD  1 
ATOM   438  O  OE1 . GLU A 1 58  ? -25.93006 36.27508 -10.41122 1.000 16.71148 ? 58   GLU A OE1 1 
ATOM   439  O  OE2 . GLU A 1 58  ? -24.48008 35.65235 -11.94279 1.000 16.00961 ? 58   GLU A OE2 1 
ATOM   440  N  N   . ASN A 1 59  ? -28.60979 33.05887 -7.32534  1.000 10.22768 ? 59   ASN A N   1 
ATOM   441  C  CA  . ASN A 1 59  ? -29.08610 33.52710 -6.02672  1.000 12.83562 ? 59   ASN A CA  1 
ATOM   442  C  C   . ASN A 1 59  ? -30.48226 33.05516 -5.63090  1.000 12.56981 ? 59   ASN A C   1 
ATOM   443  O  O   . ASN A 1 59  ? -30.72226 32.86705 -4.43508  1.000 12.90245 ? 59   ASN A O   1 
ATOM   444  C  CB  . ASN A 1 59  ? -29.06196 35.05758 -5.98834  1.000 9.10105  ? 59   ASN A CB  1 
ATOM   445  C  CG  . ASN A 1 59  ? -27.66016 35.60417 -5.81640  1.000 13.07743 ? 59   ASN A CG  1 
ATOM   446  O  OD1 . ASN A 1 59  ? -27.01803 35.38993 -4.78550  1.000 12.11529 ? 59   ASN A OD1 1 
ATOM   447  N  ND2 . ASN A 1 59  ? -27.16648 36.29044 -6.84072  1.000 11.61340 ? 59   ASN A ND2 1 
ATOM   448  N  N   . VAL A 1 60  ? -31.41882 32.85534 -6.56177  1.000 12.22902 ? 60   VAL A N   1 
ATOM   449  C  CA  . VAL A 1 60  ? -32.81613 32.72672 -6.14684  1.000 9.47134  ? 60   VAL A CA  1 
ATOM   450  C  C   . VAL A 1 60  ? -33.16450 31.37554 -5.54845  1.000 13.51437 ? 60   VAL A C   1 
ATOM   451  O  O   . VAL A 1 60  ? -34.32148 31.17256 -5.16301  1.000 10.77151 ? 60   VAL A O   1 
ATOM   452  C  CB  . VAL A 1 60  ? -33.79443 33.02563 -7.29979  1.000 13.77550 ? 60   VAL A CB  1 
ATOM   453  C  CG1 . VAL A 1 60  ? -33.63873 34.47348 -7.76129  1.000 16.12744 ? 60   VAL A CG1 1 
ATOM   454  C  CG2 . VAL A 1 60  ? -33.60213 32.04830 -8.44121  1.000 11.38825 ? 60   VAL A CG2 1 
ATOM   455  N  N   . MET A 1 61  ? -32.21827 30.44531 -5.42159  1.000 12.35114 ? 61   MET A N   1 
ATOM   456  C  CA  . MET A 1 61  ? -32.51736 29.19472 -4.73569  1.000 11.05284 ? 61   MET A CA  1 
ATOM   457  C  C   . MET A 1 61  ? -31.78234 29.06998 -3.41137  1.000 14.62621 ? 61   MET A C   1 
ATOM   458  O  O   . MET A 1 61  ? -31.83664 28.00737 -2.78086  1.000 12.45524 ? 61   MET A O   1 
ATOM   459  C  CB  . MET A 1 61  ? -32.22224 27.99361 -5.63912  1.000 10.50275 ? 61   MET A CB  1 
ATOM   460  C  CG  . MET A 1 61  ? -33.18520 27.91513 -6.83209  1.000 10.30471 ? 61   MET A CG  1 
ATOM   461  S  SD  . MET A 1 61  ? -33.03888 26.39257 -7.81269  1.000 13.13501 ? 61   MET A SD  1 
ATOM   462  C  CE  . MET A 1 61  ? -33.66498 26.98881 -9.39375  1.000 9.17640  ? 61   MET A CE  1 
ATOM   463  N  N   . LYS A 1 62  ? -31.10233 30.12794 -2.97493  1.000 10.37936 ? 62   LYS A N   1 
ATOM   464  C  CA  . LYS A 1 62  ? -30.46855 30.12872 -1.66834  1.000 13.82645 ? 62   LYS A CA  1 
ATOM   465  C  C   . LYS A 1 62  ? -31.53062 30.22365 -0.56985  1.000 11.94409 ? 62   LYS A C   1 
ATOM   466  O  O   . LYS A 1 62  ? -32.66398 30.63789 -0.82631  1.000 12.39844 ? 62   LYS A O   1 
ATOM   467  C  CB  . LYS A 1 62  ? -29.46827 31.28022 -1.58007  1.000 10.03791 ? 62   LYS A CB  1 
ATOM   468  C  CG  . LYS A 1 62  ? -28.17615 31.00107 -2.37978  1.000 13.29157 ? 62   LYS A CG  1 
ATOM   469  C  CD  . LYS A 1 62  ? -27.34128 32.26687 -2.60134  1.000 12.67853 ? 62   LYS A CD  1 
ATOM   470  C  CE  . LYS A 1 62  ? -26.06825 31.96918 -3.42911  1.000 17.12514 ? 62   LYS A CE  1 
ATOM   471  N  NZ  . LYS A 1 62  ? -25.35926 33.19700 -3.92518  1.000 11.47136 ? 62   LYS A NZ  1 
ATOM   472  N  N   . PRO A 1 63  ? -31.18961 29.82153 0.66073   1.000 12.69035 ? 63   PRO A N   1 
ATOM   473  C  CA  . PRO A 1 63  ? -32.22273 29.71416 1.71385   1.000 13.65377 ? 63   PRO A CA  1 
ATOM   474  C  C   . PRO A 1 63  ? -33.04537 30.96538 1.93525   1.000 12.30257 ? 63   PRO A C   1 
ATOM   475  O  O   . PRO A 1 63  ? -34.27957 30.88089 2.05344   1.000 13.97594 ? 63   PRO A O   1 
ATOM   476  C  CB  . PRO A 1 63  ? -31.39283 29.36178 2.95515   1.000 12.11272 ? 63   PRO A CB  1 
ATOM   477  C  CG  . PRO A 1 63  ? -30.25321 28.57833 2.39729   1.000 12.63556 ? 63   PRO A CG  1 
ATOM   478  C  CD  . PRO A 1 63  ? -29.89302 29.28374 1.11466   1.000 10.38373 ? 63   PRO A CD  1 
ATOM   479  N  N   . ILE A 1 64  ? -32.39761 32.13199 2.00184   1.000 13.86108 ? 64   ILE A N   1 
ATOM   480  C  CA  . ILE A 1 64  ? -33.13102 33.35901 2.28318   1.000 15.74345 ? 64   ILE A CA  1 
ATOM   481  C  C   . ILE A 1 64  ? -34.02488 33.72397 1.11162   1.000 17.61160 ? 64   ILE A C   1 
ATOM   482  O  O   . ILE A 1 64  ? -35.05562 34.38664 1.29008   1.000 13.83996 ? 64   ILE A O   1 
ATOM   483  C  CB  . ILE A 1 64  ? -32.16090 34.50370 2.63254   1.000 19.38517 ? 64   ILE A CB  1 
ATOM   484  C  CG1 . ILE A 1 64  ? -32.90190 35.60533 3.39081   1.000 16.04806 ? 64   ILE A CG1 1 
ATOM   485  C  CG2 . ILE A 1 64  ? -31.50781 35.08129 1.36952   1.000 11.02881 ? 64   ILE A CG2 1 
ATOM   486  C  CD1 . ILE A 1 64  ? -31.97415 36.60716 4.07466   1.000 21.20332 ? 64   ILE A CD1 1 
ATOM   487  N  N   . SER A 1 65  ? -33.65587 33.30189 -0.10006  1.000 11.94411 ? 65   SER A N   1 
ATOM   488  C  CA  . SER A 1 65  ? -34.49823 33.56087 -1.26009  1.000 16.40500 ? 65   SER A CA  1 
ATOM   489  C  C   . SER A 1 65  ? -35.73008 32.66699 -1.25924  1.000 14.48425 ? 65   SER A C   1 
ATOM   490  O  O   . SER A 1 65  ? -36.78120 33.06384 -1.77402  1.000 17.03685 ? 65   SER A O   1 
ATOM   491  C  CB  . SER A 1 65  ? -33.70637 33.34640 -2.54767  1.000 15.35406 ? 65   SER A CB  1 
ATOM   492  O  OG  . SER A 1 65  ? -32.57940 34.21586 -2.60182  1.000 18.99961 ? 65   SER A OG  1 
ATOM   493  N  N   . ILE A 1 66  ? -35.62296 31.46647 -0.69726  1.000 13.49941 ? 66   ILE A N   1 
ATOM   494  C  CA  . ILE A 1 66  ? -36.72996 30.51075 -0.73817  1.000 13.49428 ? 66   ILE A CA  1 
ATOM   495  C  C   . ILE A 1 66  ? -37.66205 30.66639 0.45787   1.000 16.02730 ? 66   ILE A C   1 
ATOM   496  O  O   . ILE A 1 66  ? -38.88630 30.64172 0.30034   1.000 15.42246 ? 66   ILE A O   1 
ATOM   497  C  CB  . ILE A 1 66  ? -36.19022 29.07154 -0.82950  1.000 14.09522 ? 66   ILE A CB  1 
ATOM   498  C  CG1 . ILE A 1 66  ? -35.41772 28.85861 -2.13850  1.000 14.54777 ? 66   ILE A CG1 1 
ATOM   499  C  CG2 . ILE A 1 66  ? -37.33424 28.06572 -0.67002  1.000 14.84286 ? 66   ILE A CG2 1 
ATOM   500  C  CD1 . ILE A 1 66  ? -36.27843 28.84419 -3.38545  1.000 12.18831 ? 66   ILE A CD1 1 
ATOM   501  N  N   . GLN A 1 67  ? -37.13437 30.77906 1.67968   1.000 12.47790 ? 67   GLN A N   1 
ATOM   502  C  CA  . GLN A 1 67  ? -37.97154 30.89368 2.88266   1.000 15.35313 ? 67   GLN A CA  1 
ATOM   503  C  C   . GLN A 1 67  ? -37.50663 32.06688 3.74155   1.000 15.13217 ? 67   GLN A C   1 
ATOM   504  O  O   . GLN A 1 67  ? -36.96156 31.87558 4.83342   1.000 16.55595 ? 67   GLN A O   1 
ATOM   505  C  CB  . GLN A 1 67  ? -37.98397 29.59228 3.69169   1.000 12.59853 ? 67   GLN A CB  1 
ATOM   506  C  CG  . GLN A 1 67  ? -39.28366 29.42540 4.52961   1.000 16.12832 ? 67   GLN A CG  1 
ATOM   507  C  CD  . GLN A 1 67  ? -39.30811 28.19840 5.45030   1.000 16.32712 ? 67   GLN A CD  1 
ATOM   508  O  OE1 . GLN A 1 67  ? -40.22639 28.04024 6.26286   1.000 16.14373 ? 67   GLN A OE1 1 
ATOM   509  N  NE2 . GLN A 1 67  ? -38.32354 27.32257 5.31067   1.000 12.33054 ? 67   GLN A NE2 1 
ATOM   510  N  N   . PRO A 1 68  ? -37.74086 33.30428 3.28501   1.000 11.39825 ? 68   PRO A N   1 
ATOM   511  C  CA  . PRO A 1 68  ? -37.24228 34.47001 4.03403   1.000 17.32673 ? 68   PRO A CA  1 
ATOM   512  C  C   . PRO A 1 68  ? -37.88839 34.64378 5.39506   1.000 17.37091 ? 68   PRO A C   1 
ATOM   513  O  O   . PRO A 1 68  ? -37.25621 35.21468 6.29353   1.000 17.56955 ? 68   PRO A O   1 
ATOM   514  C  CB  . PRO A 1 68  ? -37.57468 35.64852 3.11120   1.000 13.17000 ? 68   PRO A CB  1 
ATOM   515  C  CG  . PRO A 1 68  ? -38.74085 35.16657 2.31348   1.000 17.50403 ? 68   PRO A CG  1 
ATOM   516  C  CD  . PRO A 1 68  ? -38.49353 33.70058 2.08634   1.000 15.71366 ? 68   PRO A CD  1 
ATOM   517  N  N   . GLU A 1 69  ? -39.13749 34.20811 5.56188   1.000 16.36238 ? 69   GLU A N   1 
ATOM   518  C  CA  . GLU A 1 69  ? -39.77638 34.09256 6.86203   1.000 19.54881 ? 69   GLU A CA  1 
ATOM   519  C  C   . GLU A 1 69  ? -40.27034 32.66460 6.99379   1.000 13.72914 ? 69   GLU A C   1 
ATOM   520  O  O   . GLU A 1 69  ? -40.61217 32.03194 5.99420   1.000 16.30876 ? 69   GLU A O   1 
ATOM   521  C  CB  . GLU A 1 69  ? -40.96588 35.05988 7.02797   1.000 19.48901 ? 69   GLU A CB  1 
ATOM   522  C  CG  . GLU A 1 69  ? -40.68547 36.53484 6.77730   1.000 26.82279 ? 69   GLU A CG  1 
ATOM   523  C  CD  . GLU A 1 69  ? -41.97984 37.36714 6.72408   1.000 35.33543 ? 69   GLU A CD  1 
ATOM   524  O  OE1 . GLU A 1 69  ? -42.88772 37.14363 7.55643   1.000 42.46650 ? 69   GLU A OE1 1 
ATOM   525  O  OE2 . GLU A 1 69  ? -42.09959 38.24342 5.84374   1.000 38.71170 ? 69   GLU A OE2 1 
ATOM   526  N  N   . GLU A 1 70  ? -40.30677 32.15143 8.22155   1.000 13.54906 ? 70   GLU A N   1 
ATOM   527  C  CA  . GLU A 1 70  ? -40.78148 30.78444 8.40736   1.000 14.89241 ? 70   GLU A CA  1 
ATOM   528  C  C   . GLU A 1 70  ? -42.19506 30.61755 7.86867   1.000 21.31121 ? 70   GLU A C   1 
ATOM   529  O  O   . GLU A 1 70  ? -43.11265 31.36432 8.23064   1.000 17.46616 ? 70   GLU A O   1 
ATOM   530  C  CB  . GLU A 1 70  ? -40.75282 30.37695 9.87322   1.000 15.85426 ? 70   GLU A CB  1 
ATOM   531  C  CG  . GLU A 1 70  ? -41.05244 28.89182 10.03587  1.000 14.72340 ? 70   GLU A CG  1 
ATOM   532  C  CD  . GLU A 1 70  ? -40.87222 28.40264 11.46336  1.000 18.62451 ? 70   GLU A CD  1 
ATOM   533  O  OE1 . GLU A 1 70  ? -40.67200 29.24984 12.36529  1.000 23.08044 ? 70   GLU A OE1 1 
ATOM   534  O  OE2 . GLU A 1 70  ? -40.94274 27.17225 11.67807  1.000 19.35483 ? 70   GLU A OE2 1 
ATOM   535  N  N   . GLY A 1 71  ? -42.36893 29.62240 7.00621   1.000 17.62093 ? 71   GLY A N   1 
ATOM   536  C  CA  . GLY A 1 71  ? -43.65054 29.37599 6.39539   1.000 16.99365 ? 71   GLY A CA  1 
ATOM   537  C  C   . GLY A 1 71  ? -43.96846 30.19294 5.15751   1.000 17.71147 ? 71   GLY A C   1 
ATOM   538  O  O   . GLY A 1 71  ? -44.99255 29.92811 4.51932   1.000 15.67166 ? 71   GLY A O   1 
ATOM   539  N  N   . LYS A 1 72  ? -43.14646 31.17899 4.78675   1.000 15.18798 ? 72   LYS A N   1 
ATOM   540  C  CA  . LYS A 1 72  ? -43.33554 31.90254 3.52860   1.000 17.07889 ? 72   LYS A CA  1 
ATOM   541  C  C   . LYS A 1 72  ? -42.33572 31.36189 2.51890   1.000 17.30252 ? 72   LYS A C   1 
ATOM   542  O  O   . LYS A 1 72  ? -41.13978 31.63839 2.62766   1.000 17.48551 ? 72   LYS A O   1 
ATOM   543  C  CB  . LYS A 1 72  ? -43.16190 33.41064 3.70529   1.000 19.45213 ? 72   LYS A CB  1 
ATOM   544  C  CG  . LYS A 1 72  ? -43.95356 33.99250 4.86180   1.000 30.75975 ? 72   LYS A CG  1 
ATOM   545  C  CD  . LYS A 1 72  ? -44.14851 35.49701 4.70890   1.000 38.43190 ? 72   LYS A CD  1 
ATOM   546  C  CE  . LYS A 1 72  ? -45.45534 35.94782 5.35706   1.000 38.94124 ? 72   LYS A CE  1 
ATOM   547  N  NZ  . LYS A 1 72  ? -46.47836 34.85532 5.32065   1.000 38.54739 ? 72   LYS A NZ  1 
ATOM   548  N  N   . PHE A 1 73  ? -42.81875 30.59511 1.53986   1.000 14.17633 ? 73   PHE A N   1 
ATOM   549  C  CA  . PHE A 1 73  ? -41.95790 30.05235 0.49238   1.000 15.96376 ? 73   PHE A CA  1 
ATOM   550  C  C   . PHE A 1 73  ? -42.18451 30.84359 -0.78692  1.000 19.75027 ? 73   PHE A C   1 
ATOM   551  O  O   . PHE A 1 73  ? -43.32650 30.97372 -1.24367  1.000 19.05376 ? 73   PHE A O   1 
ATOM   552  C  CB  . PHE A 1 73  ? -42.23508 28.56961 0.26134   1.000 14.90910 ? 73   PHE A CB  1 
ATOM   553  C  CG  . PHE A 1 73  ? -41.86390 27.70759 1.42615   1.000 17.57392 ? 73   PHE A CG  1 
ATOM   554  C  CD1 . PHE A 1 73  ? -42.75999 27.51344 2.47158   1.000 16.56325 ? 73   PHE A CD1 1 
ATOM   555  C  CD2 . PHE A 1 73  ? -40.61150 27.12226 1.50152   1.000 13.39628 ? 73   PHE A CD2 1 
ATOM   556  C  CE1 . PHE A 1 73  ? -42.41874 26.72571 3.55730   1.000 14.49270 ? 73   PHE A CE1 1 
ATOM   557  C  CE2 . PHE A 1 73  ? -40.26260 26.33014 2.59559   1.000 14.89249 ? 73   PHE A CE2 1 
ATOM   558  C  CZ  . PHE A 1 73  ? -41.16264 26.13484 3.61603   1.000 18.36197 ? 73   PHE A CZ  1 
ATOM   559  N  N   . ASN A 1 74  ? -41.10815 31.38171 -1.35038  1.000 14.82867 ? 74   ASN A N   1 
ATOM   560  C  CA  . ASN A 1 74  ? -41.14196 32.09256 -2.63027  1.000 15.33202 ? 74   ASN A CA  1 
ATOM   561  C  C   . ASN A 1 74  ? -40.45531 31.21627 -3.67556  1.000 20.23505 ? 74   ASN A C   1 
ATOM   562  O  O   . ASN A 1 74  ? -39.24404 31.30149 -3.86911  1.000 15.63475 ? 74   ASN A O   1 
ATOM   563  C  CB  . ASN A 1 74  ? -40.45652 33.45610 -2.51351  1.000 21.30739 ? 74   ASN A CB  1 
ATOM   564  C  CG  . ASN A 1 74  ? -41.22663 34.41856 -1.61285  1.000 36.72701 ? 74   ASN A CG  1 
ATOM   565  O  OD1 . ASN A 1 74  ? -42.45026 34.31817 -1.48726  1.000 38.77690 ? 74   ASN A OD1 1 
ATOM   566  N  ND2 . ASN A 1 74  ? -40.51453 35.36509 -0.99205  1.000 40.20674 ? 74   ASN A ND2 1 
ATOM   567  N  N   . PHE A 1 75  ? -41.23104 30.35678 -4.33513  1.000 11.99153 ? 75   PHE A N   1 
ATOM   568  C  CA  . PHE A 1 75  ? -40.70661 29.53414 -5.41871  1.000 15.28792 ? 75   PHE A CA  1 
ATOM   569  C  C   . PHE A 1 75  ? -40.82281 30.19968 -6.78646  1.000 16.13465 ? 75   PHE A C   1 
ATOM   570  O  O   . PHE A 1 75  ? -40.34286 29.63200 -7.76834  1.000 17.16757 ? 75   PHE A O   1 
ATOM   571  C  CB  . PHE A 1 75  ? -41.42598 28.18048 -5.46521  1.000 15.50861 ? 75   PHE A CB  1 
ATOM   572  C  CG  . PHE A 1 75  ? -41.14464 27.30077 -4.28213  1.000 12.00301 ? 75   PHE A CG  1 
ATOM   573  C  CD1 . PHE A 1 75  ? -39.86698 26.82764 -4.04318  1.000 12.36134 ? 75   PHE A CD1 1 
ATOM   574  C  CD2 . PHE A 1 75  ? -42.16676 26.94522 -3.40419  1.000 15.58358 ? 75   PHE A CD2 1 
ATOM   575  C  CE1 . PHE A 1 75  ? -39.59997 26.00330 -2.94948  1.000 15.97196 ? 75   PHE A CE1 1 
ATOM   576  C  CE2 . PHE A 1 75  ? -41.91480 26.12267 -2.30912  1.000 14.13801 ? 75   PHE A CE2 1 
ATOM   577  C  CZ  . PHE A 1 75  ? -40.62806 25.65524 -2.07645  1.000 13.97616 ? 75   PHE A CZ  1 
ATOM   578  N  N   . GLU A 1 76  ? -41.42407 31.39088 -6.87343  1.000 12.18160 ? 76   GLU A N   1 
ATOM   579  C  CA  . GLU A 1 76  ? -41.73606 31.98035 -8.17546  1.000 18.21634 ? 76   GLU A CA  1 
ATOM   580  C  C   . GLU A 1 76  ? -40.47740 32.20385 -9.01429  1.000 17.82152 ? 76   GLU A C   1 
ATOM   581  O  O   . GLU A 1 76  ? -40.46616 31.91932 -10.21746 1.000 17.55923 ? 76   GLU A O   1 
ATOM   582  C  CB  . GLU A 1 76  ? -42.49502 33.29757 -7.98029  1.000 20.98074 ? 76   GLU A CB  1 
ATOM   583  C  CG  . GLU A 1 76  ? -43.07835 33.88193 -9.26284  1.000 31.21575 ? 76   GLU A CG  1 
ATOM   584  C  CD  . GLU A 1 76  ? -43.58679 35.31948 -9.07517  1.000 47.80950 ? 76   GLU A CD  1 
ATOM   585  O  OE1 . GLU A 1 76  ? -42.80649 36.16052 -8.56501  1.000 50.76452 ? 76   GLU A OE1 1 
ATOM   586  O  OE2 . GLU A 1 76  ? -44.75986 35.60625 -9.43580  1.000 39.45828 ? 76   GLU A OE2 1 
ATOM   587  N  N   . GLN A 1 77  ? -39.40471 32.70915 -8.39918  1.000 14.44637 ? 77   GLN A N   1 
ATOM   588  C  CA  . GLN A 1 77  ? -38.17431 32.96219 -9.15122  1.000 16.29127 ? 77   GLN A CA  1 
ATOM   589  C  C   . GLN A 1 77  ? -37.48540 31.65802 -9.55046  1.000 16.27048 ? 77   GLN A C   1 
ATOM   590  O  O   . GLN A 1 77  ? -37.12118 31.46752 -10.71789 1.000 15.04646 ? 77   GLN A O   1 
ATOM   591  C  CB  . GLN A 1 77  ? -37.24325 33.84526 -8.32596  1.000 20.28879 ? 77   GLN A CB  1 
ATOM   592  C  CG  . GLN A 1 77  ? -37.77789 35.26081 -8.14276  1.000 18.77016 ? 77   GLN A CG  1 
ATOM   593  C  CD  . GLN A 1 77  ? -37.51202 36.13425 -9.36189  1.000 28.35462 ? 77   GLN A CD  1 
ATOM   594  O  OE1 . GLN A 1 77  ? -38.26888 36.11392 -10.33746 1.000 33.45054 ? 77   GLN A OE1 1 
ATOM   595  N  NE2 . GLN A 1 77  ? -36.42296 36.89762 -9.31532  1.000 35.12327 ? 77   GLN A NE2 1 
ATOM   596  N  N   . ALA A 1 78  ? -37.31677 30.73732 -8.59555  1.000 11.68891 ? 78   ALA A N   1 
ATOM   597  C  CA  . ALA A 1 78  ? -36.72226 29.44202 -8.90875  1.000 11.59406 ? 78   ALA A CA  1 
ATOM   598  C  C   . ALA A 1 78  ? -37.51815 28.70588 -9.98591  1.000 16.13650 ? 78   ALA A C   1 
ATOM   599  O  O   . ALA A 1 78  ? -36.93275 28.08667 -10.88483 1.000 12.15381 ? 78   ALA A O   1 
ATOM   600  C  CB  . ALA A 1 78  ? -36.61675 28.60295 -7.63307  1.000 13.82428 ? 78   ALA A CB  1 
ATOM   601  N  N   . ASP A 1 79  ? -38.85658 28.77206 -9.92047  1.000 12.14533 ? 79   ASP A N   1 
ATOM   602  C  CA  . ASP A 1 79  ? -39.69194 28.12309 -10.92985 1.000 14.03490 ? 79   ASP A CA  1 
ATOM   603  C  C   . ASP A 1 79  ? -39.35440 28.60543 -12.33573 1.000 14.14577 ? 79   ASP A C   1 
ATOM   604  O  O   . ASP A 1 79  ? -39.43002 27.83361 -13.30251 1.000 10.72069 ? 79   ASP A O   1 
ATOM   605  C  CB  . ASP A 1 79  ? -41.17705 28.39516 -10.66112 1.000 15.18870 ? 79   ASP A CB  1 
ATOM   606  C  CG  . ASP A 1 79  ? -41.74103 27.60206 -9.48227  1.000 20.65847 ? 79   ASP A CG  1 
ATOM   607  O  OD1 . ASP A 1 79  ? -41.11222 26.63481 -9.00782  1.000 16.83705 ? 79   ASP A OD1 1 
ATOM   608  O  OD2 . ASP A 1 79  ? -42.85252 27.95634 -9.03913  1.000 17.52950 ? 79   ASP A OD2 1 
ATOM   609  N  N   . ARG A 1 80  ? -39.05220 29.89755 -12.48228 1.000 12.34928 ? 80   ARG A N   1 
ATOM   610  C  CA  A ARG A 1 80  ? -38.75860 30.41885 -13.81032 0.535 16.67628 ? 80   ARG A CA  1 
ATOM   611  C  CA  B ARG A 1 80  ? -38.73599 30.44653 -13.79913 0.465 16.67480 ? 80   ARG A CA  1 
ATOM   612  C  C   . ARG A 1 80  ? -37.49778 29.77965 -14.38672 1.000 15.71133 ? 80   ARG A C   1 
ATOM   613  O  O   . ARG A 1 80  ? -37.43562 29.49202 -15.58781 1.000 13.06417 ? 80   ARG A O   1 
ATOM   614  C  CB  A ARG A 1 80  ? -38.64832 31.94339 -13.74971 0.535 17.17183 ? 80   ARG A CB  1 
ATOM   615  C  CB  B ARG A 1 80  ? -38.52795 31.96031 -13.69111 0.465 17.10786 ? 80   ARG A CB  1 
ATOM   616  C  CG  A ARG A 1 80  ? -40.02036 32.62870 -13.76253 0.535 17.39255 ? 80   ARG A CG  1 
ATOM   617  C  CG  B ARG A 1 80  ? -39.81186 32.78924 -13.72271 0.465 17.76344 ? 80   ARG A CG  1 
ATOM   618  C  CD  A ARG A 1 80  ? -39.99934 34.02297 -13.15148 0.535 21.46950 ? 80   ARG A CD  1 
ATOM   619  C  CD  B ARG A 1 80  ? -39.65352 34.11228 -12.96836 0.465 21.05670 ? 80   ARG A CD  1 
ATOM   620  N  NE  A ARG A 1 80  ? -41.35562 34.55616 -13.01710 0.535 24.53764 ? 80   ARG A NE  1 
ATOM   621  N  NE  B ARG A 1 80  ? -38.98608 35.15293 -13.75096 0.465 22.26164 ? 80   ARG A NE  1 
ATOM   622  C  CZ  A ARG A 1 80  ? -41.72562 35.44871 -12.10624 0.535 28.33571 ? 80   ARG A CZ  1 
ATOM   623  C  CZ  B ARG A 1 80  ? -38.86674 36.42026 -13.35734 0.465 24.29887 ? 80   ARG A CZ  1 
ATOM   624  N  NH1 A ARG A 1 80  ? -40.84007 35.92018 -11.23933 0.535 28.08127 ? 80   ARG A NH1 1 
ATOM   625  N  NH1 B ARG A 1 80  ? -39.37500 36.80715 -12.19660 0.465 30.69717 ? 80   ARG A NH1 1 
ATOM   626  N  NH2 A ARG A 1 80  ? -42.98433 35.86594 -12.06013 0.535 29.21381 ? 80   ARG A NH2 1 
ATOM   627  N  NH2 B ARG A 1 80  ? -38.24262 37.30257 -14.12231 0.465 23.37465 ? 80   ARG A NH2 1 
ATOM   628  N  N   . ILE A 1 81  ? -36.49334 29.52823 -13.54963 1.000 11.61259 ? 81   ILE A N   1 
ATOM   629  C  CA  . ILE A 1 81  ? -35.28989 28.85993 -14.03067 1.000 10.49587 ? 81   ILE A CA  1 
ATOM   630  C  C   . ILE A 1 81  ? -35.58900 27.40124 -14.35779 1.000 12.12644 ? 81   ILE A C   1 
ATOM   631  O  O   . ILE A 1 81  ? -35.12635 26.86902 -15.37426 1.000 10.96055 ? 81   ILE A O   1 
ATOM   632  C  CB  . ILE A 1 81  ? -34.16055 29.00933 -12.99447 1.000 10.57037 ? 81   ILE A CB  1 
ATOM   633  C  CG1 . ILE A 1 81  ? -33.72398 30.48054 -12.92979 1.000 11.90161 ? 81   ILE A CG1 1 
ATOM   634  C  CG2 . ILE A 1 81  ? -32.94674 28.12771 -13.36082 1.000 10.06650 ? 81   ILE A CG2 1 
ATOM   635  C  CD1 . ILE A 1 81  ? -32.90551 30.82087 -11.70831 1.000 10.41876 ? 81   ILE A CD1 1 
ATOM   636  N  N   . VAL A 1 82  ? -36.39397 26.73978 -13.52311 1.000 12.02414 ? 82   VAL A N   1 
ATOM   637  C  CA  . VAL A 1 82  ? -36.73212 25.34016 -13.77922 1.000 11.99664 ? 82   VAL A CA  1 
ATOM   638  C  C   . VAL A 1 82  ? -37.50181 25.20546 -15.08745 1.000 12.85234 ? 82   VAL A C   1 
ATOM   639  O  O   . VAL A 1 82  ? -37.22840 24.31014 -15.89830 1.000 12.49425 ? 82   VAL A O   1 
ATOM   640  C  CB  . VAL A 1 82  ? -37.53380 24.76024 -12.59843 1.000 10.91809 ? 82   VAL A CB  1 
ATOM   641  C  CG1 . VAL A 1 82  ? -38.07576 23.39187 -12.96149 1.000 10.47616 ? 82   VAL A CG1 1 
ATOM   642  C  CG2 . VAL A 1 82  ? -36.66818 24.68928 -11.34310 1.000 13.14091 ? 82   VAL A CG2 1 
ATOM   643  N  N   . LYS A 1 83  ? -38.48728 26.08125 -15.30537 1.000 12.89826 ? 83   LYS A N   1 
ATOM   644  C  CA  . LYS A 1 83  ? -39.27727 26.03622 -16.53406 1.000 17.02403 ? 83   LYS A CA  1 
ATOM   645  C  C   . LYS A 1 83  ? -38.38919 26.20255 -17.76694 1.000 13.26842 ? 83   LYS A C   1 
ATOM   646  O  O   . LYS A 1 83  ? -38.53885 25.48345 -18.76084 1.000 13.92071 ? 83   LYS A O   1 
ATOM   647  C  CB  . LYS A 1 83  ? -40.35365 27.12364 -16.49841 1.000 16.62605 ? 83   LYS A CB  1 
ATOM   648  C  CG  . LYS A 1 83  ? -41.29762 27.09928 -17.70712 1.000 29.82900 ? 83   LYS A CG  1 
ATOM   649  C  CD  . LYS A 1 83  ? -42.34088 28.22528 -17.66802 1.000 31.95377 ? 83   LYS A CD  1 
ATOM   650  C  CE  . LYS A 1 83  ? -41.74084 29.59311 -17.97332 1.000 39.07627 ? 83   LYS A CE  1 
ATOM   651  N  NZ  . LYS A 1 83  ? -42.23426 30.67632 -17.05741 1.000 47.18534 ? 83   LYS A NZ  1 
ATOM   652  N  N   . PHE A 1 84  ? -37.47333 27.16689 -17.72336 1.000 11.30010 ? 84   PHE A N   1 
ATOM   653  C  CA  . PHE A 1 84  ? -36.58401 27.40646 -18.85488 1.000 14.12603 ? 84   PHE A CA  1 
ATOM   654  C  C   . PHE A 1 84  ? -35.70129 26.19312 -19.12442 1.000 13.24070 ? 84   PHE A C   1 
ATOM   655  O  O   . PHE A 1 84  ? -35.49776 25.80091 -20.28087 1.000 11.77497 ? 84   PHE A O   1 
ATOM   656  C  CB  . PHE A 1 84  ? -35.73268 28.65643 -18.59167 1.000 13.90255 ? 84   PHE A CB  1 
ATOM   657  C  CG  . PHE A 1 84  ? -34.80025 29.00905 -19.72318 1.000 10.96737 ? 84   PHE A CG  1 
ATOM   658  C  CD1 . PHE A 1 84  ? -35.23219 29.81178 -20.77374 1.000 15.72315 ? 84   PHE A CD1 1 
ATOM   659  C  CD2 . PHE A 1 84  ? -33.49115 28.53997 -19.73358 1.000 12.55844 ? 84   PHE A CD2 1 
ATOM   660  C  CE1 . PHE A 1 84  ? -34.38420 30.14033 -21.82411 1.000 12.82732 ? 84   PHE A CE1 1 
ATOM   661  C  CE2 . PHE A 1 84  ? -32.62882 28.86625 -20.77951 1.000 12.54382 ? 84   PHE A CE2 1 
ATOM   662  C  CZ  . PHE A 1 84  ? -33.07974 29.66959 -21.82810 1.000 10.65795 ? 84   PHE A CZ  1 
ATOM   663  N  N   . ALA A 1 85  ? -35.17255 25.57960 -18.06872 1.000 12.98679 ? 85   ALA A N   1 
ATOM   664  C  CA  . ALA A 1 85  ? -34.28559 24.44046 -18.26596 1.000 9.98470  ? 85   ALA A CA  1 
ATOM   665  C  C   . ALA A 1 85  ? -35.04043 23.26340 -18.87010 1.000 14.25021 ? 85   ALA A C   1 
ATOM   666  O  O   . ALA A 1 85  ? -34.54389 22.59612 -19.78840 1.000 13.55119 ? 85   ALA A O   1 
ATOM   667  C  CB  . ALA A 1 85  ? -33.65327 24.04700 -16.93324 1.000 11.82794 ? 85   ALA A CB  1 
ATOM   668  N  N   . LYS A 1 86  ? -36.24457 22.99023 -18.36885 1.000 12.82390 ? 86   LYS A N   1 
ATOM   669  C  CA  . LYS A 1 86  ? -37.02975 21.89006 -18.92532 1.000 15.56953 ? 86   LYS A CA  1 
ATOM   670  C  C   . LYS A 1 86  ? -37.35770 22.13770 -20.39170 1.000 18.22278 ? 86   LYS A C   1 
ATOM   671  O  O   . LYS A 1 86  ? -37.21564 21.23461 -21.22775 1.000 20.74448 ? 86   LYS A O   1 
ATOM   672  C  CB  . LYS A 1 86  ? -38.30828 21.67983 -18.09955 1.000 21.60248 ? 86   LYS A CB  1 
ATOM   673  C  CG  . LYS A 1 86  ? -38.03459 21.17240 -16.68049 1.000 24.09128 ? 86   LYS A CG  1 
ATOM   674  C  CD  . LYS A 1 86  ? -39.28437 21.19244 -15.79045 1.000 31.66370 ? 86   LYS A CD  1 
ATOM   675  C  CE  . LYS A 1 86  ? -40.44964 20.48201 -16.43981 1.000 36.59474 ? 86   LYS A CE  1 
ATOM   676  N  NZ  . LYS A 1 86  ? -40.03342 19.11190 -16.84786 1.000 46.85896 ? 86   LYS A NZ  1 
ATOM   677  N  N   . ALA A 1 87  ? -37.77322 23.35971 -20.72828 1.000 15.61991 ? 87   ALA A N   1 
ATOM   678  C  CA  . ALA A 1 87  ? -38.11520 23.66139 -22.11327 1.000 16.71152 ? 87   ALA A CA  1 
ATOM   679  C  C   . ALA A 1 87  ? -36.91744 23.55741 -23.04901 1.000 18.68853 ? 87   ALA A C   1 
ATOM   680  O  O   . ALA A 1 87  ? -37.10281 23.40350 -24.26101 1.000 17.45043 ? 87   ALA A O   1 
ATOM   681  C  CB  . ALA A 1 87  ? -38.72354 25.05735 -22.21051 1.000 16.42733 ? 87   ALA A CB  1 
ATOM   682  N  N   . ASN A 1 88  ? -35.69304 23.64393 -22.52584 1.000 15.40643 ? 88   ASN A N   1 
ATOM   683  C  CA  . ASN A 1 88  ? -34.50757 23.59552 -23.36897 1.000 14.28531 ? 88   ASN A CA  1 
ATOM   684  C  C   . ASN A 1 88  ? -33.64020 22.37538 -23.09575 1.000 15.25412 ? 88   ASN A C   1 
ATOM   685  O  O   . ASN A 1 88  ? -32.49929 22.32450 -23.56642 1.000 18.18998 ? 88   ASN A O   1 
ATOM   686  C  CB  . ASN A 1 88  ? -33.71569 24.90151 -23.21264 1.000 12.84160 ? 88   ASN A CB  1 
ATOM   687  C  CG  . ASN A 1 88  ? -34.49745 26.10508 -23.74990 1.000 17.25286 ? 88   ASN A CG  1 
ATOM   688  O  OD1 . ASN A 1 88  ? -34.53957 26.32947 -24.95399 1.000 17.06585 ? 88   ASN A OD1 1 
ATOM   689  N  ND2 . ASN A 1 88  ? -35.14866 26.85268 -22.86059 1.000 16.02379 ? 88   ASN A ND2 1 
ATOM   690  N  N   . GLY A 1 89  ? -34.15781 21.38518 -22.36701 1.000 12.56326 ? 89   GLY A N   1 
ATOM   691  C  CA  . GLY A 1 89  ? -33.43592 20.14215 -22.13232 1.000 12.46764 ? 89   GLY A CA  1 
ATOM   692  C  C   . GLY A 1 89  ? -32.16095 20.29101 -21.33347 1.000 19.15099 ? 89   GLY A C   1 
ATOM   693  O  O   . GLY A 1 89  ? -31.19585 19.56155 -21.57441 1.000 14.93217 ? 89   GLY A O   1 
ATOM   694  N  N   . MET A 1 90  ? -32.12346 21.22189 -20.38973 1.000 12.07988 ? 90   MET A N   1 
ATOM   695  C  CA  . MET A 1 90  ? -30.94872 21.43896 -19.56009 1.000 11.71742 ? 90   MET A CA  1 
ATOM   696  C  C   . MET A 1 90  ? -31.06815 20.68962 -18.23486 1.000 12.38192 ? 90   MET A C   1 
ATOM   697  O  O   . MET A 1 90  ? -32.13784 20.66383 -17.63178 1.000 11.94662 ? 90   MET A O   1 
ATOM   698  C  CB  . MET A 1 90  ? -30.77919 22.93624 -19.28721 1.000 13.70238 ? 90   MET A CB  1 
ATOM   699  C  CG  . MET A 1 90  ? -30.83293 23.80877 -20.54779 1.000 11.17373 ? 90   MET A CG  1 
ATOM   700  S  SD  . MET A 1 90  ? -30.72822 25.57697 -20.18204 1.000 11.17292 ? 90   MET A SD  1 
ATOM   701  C  CE  . MET A 1 90  ? -28.94867 25.77650 -19.98187 1.000 7.68995  ? 90   MET A CE  1 
ATOM   702  N  N   . ASP A 1 91  ? -29.96070 20.09776 -17.78417 1.000 12.46964 ? 91   ASP A N   1 
ATOM   703  C  CA  . ASP A 1 91  ? -29.81750 19.70556 -16.38638 1.000 12.02448 ? 91   ASP A CA  1 
ATOM   704  C  C   . ASP A 1 91  ? -29.97356 20.91960 -15.46796 1.000 12.93609 ? 91   ASP A C   1 
ATOM   705  O  O   . ASP A 1 91  ? -29.64988 22.05123 -15.83292 1.000 11.81241 ? 91   ASP A O   1 
ATOM   706  C  CB  . ASP A 1 91  ? -28.44061 19.07936 -16.13817 1.000 11.82194 ? 91   ASP A CB  1 
ATOM   707  C  CG  . ASP A 1 91  ? -28.29621 17.69054 -16.74717 1.000 18.43859 ? 91   ASP A CG  1 
ATOM   708  O  OD1 . ASP A 1 91  ? -29.32314 17.09624 -17.11471 1.000 14.78417 ? 91   ASP A OD1 1 
ATOM   709  O  OD2 . ASP A 1 91  ? -27.14868 17.19709 -16.85032 1.000 16.97169 ? 91   ASP A OD2 1 
ATOM   710  N  N   . ILE A 1 92  ? -30.43660 20.67594 -14.24577 1.000 11.04151 ? 92   ILE A N   1 
ATOM   711  C  CA  . ILE A 1 92  ? -30.53683 21.72010 -13.23335 1.000 8.51575  ? 92   ILE A CA  1 
ATOM   712  C  C   . ILE A 1 92  ? -29.72245 21.29882 -12.02161 1.000 8.78801  ? 92   ILE A C   1 
ATOM   713  O  O   . ILE A 1 92  ? -29.78343 20.13917 -11.60488 1.000 13.13697 ? 92   ILE A O   1 
ATOM   714  C  CB  . ILE A 1 92  ? -32.00612 21.97134 -12.83499 1.000 11.05076 ? 92   ILE A CB  1 
ATOM   715  C  CG1 . ILE A 1 92  ? -32.88095 22.16308 -14.07695 1.000 11.63967 ? 92   ILE A CG1 1 
ATOM   716  C  CG2 . ILE A 1 92  ? -32.11760 23.15378 -11.85310 1.000 8.00119  ? 92   ILE A CG2 1 
ATOM   717  C  CD1 . ILE A 1 92  ? -34.39610 22.13505 -13.76862 1.000 8.05874  ? 92   ILE A CD1 1 
ATOM   718  N  N   . ARG A 1 93  ? -28.95379 22.23458 -11.46817 1.000 9.45293  ? 93   ARG A N   1 
ATOM   719  C  CA  . ARG A 1 93  ? -28.34576 22.09798 -10.15024 1.000 9.64944  ? 93   ARG A CA  1 
ATOM   720  C  C   . ARG A 1 93  ? -29.06817 23.03489 -9.19496  1.000 10.61904 ? 93   ARG A C   1 
ATOM   721  O  O   . ARG A 1 93  ? -29.39093 24.16767 -9.56086  1.000 9.78938  ? 93   ARG A O   1 
ATOM   722  C  CB  . ARG A 1 93  ? -26.84223 22.43571 -10.16810 1.000 9.57654  ? 93   ARG A CB  1 
ATOM   723  C  CG  . ARG A 1 93  ? -26.01733 21.73995 -11.25525 1.000 10.92735 ? 93   ARG A CG  1 
ATOM   724  C  CD  . ARG A 1 93  ? -24.51457 21.85562 -10.98436 1.000 11.29136 ? 93   ARG A CD  1 
ATOM   725  N  NE  . ARG A 1 93  ? -24.11169 20.96194 -9.90154  1.000 11.97227 ? 93   ARG A NE  1 
ATOM   726  C  CZ  . ARG A 1 93  ? -23.91422 21.34121 -8.64300  1.000 12.42689 ? 93   ARG A CZ  1 
ATOM   727  N  NH1 . ARG A 1 93  ? -24.07242 22.61188 -8.29820  1.000 12.82270 ? 93   ARG A NH1 1 
ATOM   728  N  NH2 . ARG A 1 93  ? -23.55766 20.44112 -7.72192  1.000 11.09377 ? 93   ARG A NH2 1 
ATOM   729  N  N   . PHE A 1 94  ? -29.34243 22.56207 -7.98111  1.000 12.23715 ? 94   PHE A N   1 
ATOM   730  C  CA  . PHE A 1 94  ? -29.95471 23.38717 -6.94730  1.000 9.72500  ? 94   PHE A CA  1 
ATOM   731  C  C   . PHE A 1 94  ? -28.87361 23.94121 -6.02634  1.000 11.53630 ? 94   PHE A C   1 
ATOM   732  O  O   . PHE A 1 94  ? -28.21968 23.18691 -5.29600  1.000 13.71575 ? 94   PHE A O   1 
ATOM   733  C  CB  . PHE A 1 94  ? -30.98813 22.60768 -6.13127  1.000 9.49997  ? 94   PHE A CB  1 
ATOM   734  C  CG  . PHE A 1 94  ? -31.74975 23.46807 -5.15949  1.000 12.12491 ? 94   PHE A CG  1 
ATOM   735  C  CD1 . PHE A 1 94  ? -31.19264 23.81924 -3.93519  1.000 11.22464 ? 94   PHE A CD1 1 
ATOM   736  C  CD2 . PHE A 1 94  ? -33.01881 23.93317 -5.47429  1.000 8.04168  ? 94   PHE A CD2 1 
ATOM   737  C  CE1 . PHE A 1 94  ? -31.88203 24.63489 -3.04837  1.000 11.27144 ? 94   PHE A CE1 1 
ATOM   738  C  CE2 . PHE A 1 94  ? -33.72106 24.74588 -4.59378  1.000 11.44693 ? 94   PHE A CE2 1 
ATOM   739  C  CZ  . PHE A 1 94  ? -33.16013 25.09502 -3.38497  1.000 12.32188 ? 94   PHE A CZ  1 
ATOM   740  N  N   . HIS A 1 95  ? -28.72775 25.26164 -6.02189  1.000 10.41899 ? 95   HIS A N   1 
ATOM   741  C  CA  . HIS A 1 95  ? -27.78921 25.95069 -5.14257  1.000 14.74130 ? 95   HIS A CA  1 
ATOM   742  C  C   . HIS A 1 95  ? -28.58075 26.92217 -4.27311  1.000 11.31777 ? 95   HIS A C   1 
ATOM   743  O  O   . HIS A 1 95  ? -29.08835 27.92361 -4.78459  1.000 12.02020 ? 95   HIS A O   1 
ATOM   744  C  CB  . HIS A 1 95  ? -26.73983 26.67844 -5.98214  1.000 9.81936  ? 95   HIS A CB  1 
ATOM   745  C  CG  . HIS A 1 95  ? -25.69900 27.38789 -5.17907  1.000 14.62861 ? 95   HIS A CG  1 
ATOM   746  N  ND1 . HIS A 1 95  ? -24.66126 26.72614 -4.55909  1.000 15.35197 ? 95   HIS A ND1 1 
ATOM   747  C  CD2 . HIS A 1 95  ? -25.52642 28.70341 -4.90914  1.000 15.77937 ? 95   HIS A CD2 1 
ATOM   748  C  CE1 . HIS A 1 95  ? -23.90421 27.60434 -3.92327  1.000 19.47034 ? 95   HIS A CE1 1 
ATOM   749  N  NE2 . HIS A 1 95  ? -24.39956 28.81109 -4.13027  1.000 18.32063 ? 95   HIS A NE2 1 
ATOM   750  N  N   . THR A 1 96  ? -28.70338 26.65416 -2.96358  1.000 10.06037 ? 96   THR A N   1 
ATOM   751  C  CA  . THR A 1 96  ? -28.17671 25.50967 -2.21878  1.000 8.56227  ? 96   THR A CA  1 
ATOM   752  C  C   . THR A 1 96  ? -29.09223 25.33455 -0.98848  1.000 12.26821 ? 96   THR A C   1 
ATOM   753  O  O   . THR A 1 96  ? -29.72541 26.29076 -0.54642  1.000 11.38893 ? 96   THR A O   1 
ATOM   754  C  CB  . THR A 1 96  ? -26.68911 25.72493 -1.76041  1.000 11.70964 ? 96   THR A CB  1 
ATOM   755  O  OG1 . THR A 1 96  ? -26.28334 24.65840 -0.89429  1.000 11.63313 ? 96   THR A OG1 1 
ATOM   756  C  CG2 . THR A 1 96  ? -26.55369 27.02765 -1.00811  1.000 9.50689  ? 96   THR A CG2 1 
ATOM   757  N  N   . LEU A 1 97  ? -29.17678 24.12428 -0.43285  1.000 11.79924 ? 97   LEU A N   1 
ATOM   758  C  CA  . LEU A 1 97  ? -30.14907 23.89068 0.63128   1.000 11.45652 ? 97   LEU A CA  1 
ATOM   759  C  C   . LEU A 1 97  ? -29.70257 24.47355 1.97146   1.000 16.69803 ? 97   LEU A C   1 
ATOM   760  O  O   . LEU A 1 97  ? -30.55423 24.88275 2.76988   1.000 13.28365 ? 97   LEU A O   1 
ATOM   761  C  CB  . LEU A 1 97  ? -30.43684 22.38743 0.77210   1.000 10.97686 ? 97   LEU A CB  1 
ATOM   762  C  CG  . LEU A 1 97  ? -31.29045 21.71605 -0.32074  1.000 9.99639  ? 97   LEU A CG  1 
ATOM   763  C  CD1 . LEU A 1 97  ? -31.36223 20.20710 -0.14047  1.000 9.74562  ? 97   LEU A CD1 1 
ATOM   764  C  CD2 . LEU A 1 97  ? -32.69186 22.29105 -0.34492  1.000 9.26527  ? 97   LEU A CD2 1 
ATOM   765  N  N   . VAL A 1 98  ? -28.39252 24.54439 2.22975   1.000 14.12854 ? 98   VAL A N   1 
ATOM   766  C  CA  . VAL A 1 98  ? -27.85746 24.92487 3.53733   1.000 13.92375 ? 98   VAL A CA  1 
ATOM   767  C  C   . VAL A 1 98  ? -26.58446 25.73313 3.32646   1.000 14.35173 ? 98   VAL A C   1 
ATOM   768  O  O   . VAL A 1 98  ? -25.65080 25.25703 2.67312   1.000 14.34543 ? 98   VAL A O   1 
ATOM   769  C  CB  . VAL A 1 98  ? -27.52750 23.70164 4.41631   1.000 14.99525 ? 98   VAL A CB  1 
ATOM   770  C  CG1 . VAL A 1 98  ? -26.94433 24.16462 5.73834   1.000 18.32125 ? 98   VAL A CG1 1 
ATOM   771  C  CG2 . VAL A 1 98  ? -28.74631 22.80694 4.62122   1.000 13.47439 ? 98   VAL A CG2 1 
ATOM   772  N  N   . TRP A 1 99  ? -26.52732 26.92638 3.91504   1.000 14.33098 ? 99   TRP A N   1 
ATOM   773  C  CA  . TRP A 1 99  ? -25.36078 27.79625 3.81007   1.000 12.77868 ? 99   TRP A CA  1 
ATOM   774  C  C   . TRP A 1 99  ? -25.37745 28.76635 4.98551   1.000 18.56998 ? 99   TRP A C   1 
ATOM   775  O  O   . TRP A 1 99  ? -26.44426 29.12929 5.48358   1.000 17.37160 ? 99   TRP A O   1 
ATOM   776  C  CB  . TRP A 1 99  ? -25.36854 28.55419 2.48067   1.000 11.67821 ? 99   TRP A CB  1 
ATOM   777  C  CG  . TRP A 1 99  ? -24.08872 29.25072 2.09627   1.000 12.10061 ? 99   TRP A CG  1 
ATOM   778  C  CD1 . TRP A 1 99  ? -22.81281 28.94719 2.51260   1.000 14.30322 ? 99   TRP A CD1 1 
ATOM   779  C  CD2 . TRP A 1 99  ? -23.95882 30.35528 1.17913   1.000 16.46479 ? 99   TRP A CD2 1 
ATOM   780  N  NE1 . TRP A 1 99  ? -21.91169 29.80608 1.91797   1.000 15.17543 ? 99   TRP A NE1 1 
ATOM   781  C  CE2 . TRP A 1 99  ? -22.58633 30.67795 1.10192   1.000 14.55087 ? 99   TRP A CE2 1 
ATOM   782  C  CE3 . TRP A 1 99  ? -24.87199 31.10417 0.42396   1.000 16.67081 ? 99   TRP A CE3 1 
ATOM   783  C  CZ2 . TRP A 1 99  ? -22.10316 31.72680 0.29932   1.000 19.88385 ? 99   TRP A CZ2 1 
ATOM   784  C  CZ3 . TRP A 1 99  ? -24.39507 32.14674 -0.36619  1.000 16.99513 ? 99   TRP A CZ3 1 
ATOM   785  C  CH2 . TRP A 1 99  ? -23.01659 32.44360 -0.42499  1.000 19.24013 ? 99   TRP A CH2 1 
ATOM   786  N  N   . HIS A 1 100 ? -24.18821 29.19903 5.41401   1.000 16.16563 ? 100  HIS A N   1 
ATOM   787  C  CA  . HIS A 1 100 ? -24.09457 30.16603 6.50244   1.000 14.89825 ? 100  HIS A CA  1 
ATOM   788  C  C   . HIS A 1 100 ? -24.27764 31.60515 6.03617   1.000 19.09330 ? 100  HIS A C   1 
ATOM   789  O  O   . HIS A 1 100 ? -24.36835 32.50788 6.87417   1.000 17.85573 ? 100  HIS A O   1 
ATOM   790  C  CB  . HIS A 1 100 ? -22.74795 30.02586 7.20741   1.000 16.84915 ? 100  HIS A CB  1 
ATOM   791  C  CG  . HIS A 1 100 ? -21.59527 30.51028 6.39070   1.000 19.47823 ? 100  HIS A CG  1 
ATOM   792  N  ND1 . HIS A 1 100 ? -21.01061 29.74635 5.40392   1.000 15.95836 ? 100  HIS A ND1 1 
ATOM   793  C  CD2 . HIS A 1 100 ? -20.93782 31.69313 6.39341   1.000 18.41646 ? 100  HIS A CD2 1 
ATOM   794  C  CE1 . HIS A 1 100 ? -20.02977 30.43481 4.84533   1.000 19.24642 ? 100  HIS A CE1 1 
ATOM   795  N  NE2 . HIS A 1 100 ? -19.95847 31.61436 5.43561   1.000 21.03392 ? 100  HIS A NE2 1 
ATOM   796  N  N   . SER A 1 101 ? -24.31224 31.84126 4.72904   1.000 15.83761 ? 101  SER A N   1 
ATOM   797  C  CA  . SER A 1 101 ? -24.58474 33.14011 4.13695   1.000 15.59782 ? 101  SER A CA  1 
ATOM   798  C  C   . SER A 1 101 ? -25.93473 33.10003 3.43109   1.000 16.30478 ? 101  SER A C   1 
ATOM   799  O  O   . SER A 1 101 ? -26.44077 32.02850 3.10229   1.000 16.41175 ? 101  SER A O   1 
ATOM   800  C  CB  . SER A 1 101 ? -23.47422 33.51399 3.14345   1.000 17.65531 ? 101  SER A CB  1 
ATOM   801  O  OG  . SER A 1 101 ? -23.61082 34.84174 2.69269   1.000 29.24707 ? 101  SER A OG  1 
ATOM   802  N  N   . GLN A 1 102 ? -26.49368 34.27762 3.16298   1.000 17.31841 ? 102  GLN A N   1 
ATOM   803  C  CA  . GLN A 1 102 ? -27.80341 34.41033 2.51385   1.000 23.02061 ? 102  GLN A CA  1 
ATOM   804  C  C   . GLN A 1 102 ? -28.78061 33.37022 3.07034   1.000 24.33167 ? 102  GLN A C   1 
ATOM   805  O  O   . GLN A 1 102 ? -29.33609 32.51870 2.36328   1.000 15.80846 ? 102  GLN A O   1 
ATOM   806  C  CB  . GLN A 1 102 ? -27.67443 34.32179 0.98982   1.000 22.24503 ? 102  GLN A CB  1 
ATOM   807  C  CG  . GLN A 1 102 ? -27.09662 35.60652 0.37035   1.000 19.70088 ? 102  GLN A CG  1 
ATOM   808  C  CD  . GLN A 1 102 ? -26.82407 35.48414 -1.11273  1.000 21.57161 ? 102  GLN A CD  1 
ATOM   809  O  OE1 . GLN A 1 102 ? -25.72509 35.09557 -1.52365  1.000 22.20064 ? 102  GLN A OE1 1 
ATOM   810  N  NE2 . GLN A 1 102 ? -27.82137 35.82006 -1.93151  1.000 15.82894 ? 102  GLN A NE2 1 
ATOM   811  N  N   . VAL A 1 103 ? -28.95053 33.44952 4.38536   1.000 16.90620 ? 103  VAL A N   1 
ATOM   812  C  CA  . VAL A 1 103 ? -29.71974 32.47301 5.14344   1.000 21.98906 ? 103  VAL A CA  1 
ATOM   813  C  C   . VAL A 1 103 ? -30.54995 33.25039 6.15705   1.000 21.88835 ? 103  VAL A C   1 
ATOM   814  O  O   . VAL A 1 103 ? -30.01419 34.12423 6.85341   1.000 22.69172 ? 103  VAL A O   1 
ATOM   815  C  CB  . VAL A 1 103 ? -28.79825 31.44090 5.81758   1.000 22.00351 ? 103  VAL A CB  1 
ATOM   816  C  CG1 . VAL A 1 103 ? -27.69574 32.14094 6.61416   1.000 21.17173 ? 103  VAL A CG1 1 
ATOM   817  C  CG2 . VAL A 1 103 ? -29.60301 30.51061 6.71250   1.000 21.77302 ? 103  VAL A CG2 1 
ATOM   818  N  N   . PRO A 1 104 ? -31.84780 32.98320 6.27083   1.000 21.38024 ? 104  PRO A N   1 
ATOM   819  C  CA  . PRO A 1 104 ? -32.69557 33.83582 7.11259   1.000 22.40735 ? 104  PRO A CA  1 
ATOM   820  C  C   . PRO A 1 104 ? -32.40680 33.64199 8.59924   1.000 19.83713 ? 104  PRO A C   1 
ATOM   821  O  O   . PRO A 1 104 ? -32.21119 32.52235 9.08054   1.000 19.31094 ? 104  PRO A O   1 
ATOM   822  C  CB  . PRO A 1 104 ? -34.11522 33.39101 6.73902   1.000 19.36408 ? 104  PRO A CB  1 
ATOM   823  C  CG  . PRO A 1 104 ? -33.96072 32.00166 6.27023   1.000 16.63273 ? 104  PRO A CG  1 
ATOM   824  C  CD  . PRO A 1 104 ? -32.62203 31.92584 5.59356   1.000 18.20501 ? 104  PRO A CD  1 
ATOM   825  N  N   . GLN A 1 105 ? -32.36381 34.76129 9.32679   1.000 20.85975 ? 105  GLN A N   1 
ATOM   826  C  CA  . GLN A 1 105 ? -31.96438 34.71741 10.72938  1.000 21.72279 ? 105  GLN A CA  1 
ATOM   827  C  C   . GLN A 1 105 ? -32.98258 34.00958 11.61891  1.000 21.55407 ? 105  GLN A C   1 
ATOM   828  O  O   . GLN A 1 105 ? -32.60684 33.52672 12.69208  1.000 21.70050 ? 105  GLN A O   1 
ATOM   829  C  CB  . GLN A 1 105 ? -31.70624 36.13787 11.24703  1.000 25.56390 ? 105  GLN A CB  1 
ATOM   830  C  CG  . GLN A 1 105 ? -30.49907 36.80540 10.60850  1.000 31.84005 ? 105  GLN A CG  1 
ATOM   831  C  CD  . GLN A 1 105 ? -29.28837 35.87017 10.52007  1.000 49.01152 ? 105  GLN A CD  1 
ATOM   832  O  OE1 . GLN A 1 105 ? -28.72487 35.46179 11.54410  1.000 54.42534 ? 105  GLN A OE1 1 
ATOM   833  N  NE2 . GLN A 1 105 ? -28.89377 35.51603 9.28875   1.000 40.50726 ? 105  GLN A NE2 1 
ATOM   834  N  N   . TRP A 1 106 ? -34.25078 33.92059 11.19913  1.000 17.60970 ? 106  TRP A N   1 
ATOM   835  C  CA  . TRP A 1 106 ? -35.26557 33.26060 12.02267  1.000 22.28729 ? 106  TRP A CA  1 
ATOM   836  C  C   . TRP A 1 106 ? -34.93809 31.79713 12.29609  1.000 19.98310 ? 106  TRP A C   1 
ATOM   837  O  O   . TRP A 1 106 ? -35.45188 31.23078 13.26645  1.000 21.52070 ? 106  TRP A O   1 
ATOM   838  C  CB  . TRP A 1 106 ? -36.65243 33.36970 11.37025  1.000 19.08481 ? 106  TRP A CB  1 
ATOM   839  C  CG  . TRP A 1 106 ? -36.80494 32.61315 10.08276  1.000 17.32308 ? 106  TRP A CG  1 
ATOM   840  C  CD1 . TRP A 1 106 ? -36.75425 33.13296 8.81917   1.000 17.30000 ? 106  TRP A CD1 1 
ATOM   841  C  CD2 . TRP A 1 106 ? -37.05865 31.20613 9.92574   1.000 15.12383 ? 106  TRP A CD2 1 
ATOM   842  N  NE1 . TRP A 1 106 ? -36.95070 32.14267 7.89176   1.000 14.61381 ? 106  TRP A NE1 1 
ATOM   843  C  CE2 . TRP A 1 106 ? -37.13728 30.95041 8.54193   1.000 14.80807 ? 106  TRP A CE2 1 
ATOM   844  C  CE3 . TRP A 1 106 ? -37.22923 30.14141 10.82106  1.000 16.32526 ? 106  TRP A CE3 1 
ATOM   845  C  CZ2 . TRP A 1 106 ? -37.36402 29.67684 8.02874   1.000 12.65098 ? 106  TRP A CZ2 1 
ATOM   846  C  CZ3 . TRP A 1 106 ? -37.45173 28.87984 10.31387  1.000 16.24595 ? 106  TRP A CZ3 1 
ATOM   847  C  CH2 . TRP A 1 106 ? -37.51687 28.65514 8.92341   1.000 16.23536 ? 106  TRP A CH2 1 
ATOM   848  N  N   . PHE A 1 107 ? -34.11499 31.16439 11.45509  1.000 18.36217 ? 107  PHE A N   1 
ATOM   849  C  CA  . PHE A 1 107 ? -33.68559 29.79487 11.72172  1.000 18.49333 ? 107  PHE A CA  1 
ATOM   850  C  C   . PHE A 1 107 ? -33.09217 29.65390 13.11906  1.000 17.13943 ? 107  PHE A C   1 
ATOM   851  O  O   . PHE A 1 107 ? -33.27951 28.63121 13.78219  1.000 18.76177 ? 107  PHE A O   1 
ATOM   852  C  CB  . PHE A 1 107 ? -32.64620 29.35627 10.68586  1.000 20.46442 ? 107  PHE A CB  1 
ATOM   853  C  CG  . PHE A 1 107 ? -33.22566 28.66153 9.48055   1.000 16.90334 ? 107  PHE A CG  1 
ATOM   854  C  CD1 . PHE A 1 107 ? -33.89715 27.46465 9.60954   1.000 18.33103 ? 107  PHE A CD1 1 
ATOM   855  C  CD2 . PHE A 1 107 ? -33.06969 29.20897 8.21803   1.000 19.41523 ? 107  PHE A CD2 1 
ATOM   856  C  CE1 . PHE A 1 107 ? -34.41855 26.82947 8.49490   1.000 22.37023 ? 107  PHE A CE1 1 
ATOM   857  C  CE2 . PHE A 1 107 ? -33.57409 28.57837 7.10228   1.000 19.89853 ? 107  PHE A CE2 1 
ATOM   858  C  CZ  . PHE A 1 107 ? -34.24536 27.39303 7.23294   1.000 20.57614 ? 107  PHE A CZ  1 
ATOM   859  N  N   . PHE A 1 108 ? -32.35181 30.66229 13.57371  1.000 15.67494 ? 108  PHE A N   1 
ATOM   860  C  CA  . PHE A 1 108 ? -31.48000 30.50444 14.72926  1.000 22.52795 ? 108  PHE A CA  1 
ATOM   861  C  C   . PHE A 1 108 ? -32.00631 31.24063 15.96229  1.000 25.77730 ? 108  PHE A C   1 
ATOM   862  O  O   . PHE A 1 108 ? -31.23985 31.51198 16.89337  1.000 25.40778 ? 108  PHE A O   1 
ATOM   863  C  CB  . PHE A 1 108 ? -30.06086 30.96481 14.37962  1.000 18.66442 ? 108  PHE A CB  1 
ATOM   864  C  CG  . PHE A 1 108 ? -29.56441 30.44667 13.04511  1.000 19.86216 ? 108  PHE A CG  1 
ATOM   865  C  CD1 . PHE A 1 108 ? -29.33300 29.09117 12.85646  1.000 15.89591 ? 108  PHE A CD1 1 
ATOM   866  C  CD2 . PHE A 1 108 ? -29.35732 31.31505 11.98247  1.000 18.42099 ? 108  PHE A CD2 1 
ATOM   867  C  CE1 . PHE A 1 108 ? -28.88786 28.60119 11.63870  1.000 14.81174 ? 108  PHE A CE1 1 
ATOM   868  C  CE2 . PHE A 1 108 ? -28.90303 30.83659 10.75222  1.000 23.28483 ? 108  PHE A CE2 1 
ATOM   869  C  CZ  . PHE A 1 108 ? -28.67015 29.47192 10.58444  1.000 19.83135 ? 108  PHE A CZ  1 
ATOM   870  N  N   . LEU A 1 109 ? -33.29776 31.55896 15.98826  1.000 24.09672 ? 109  LEU A N   1 
ATOM   871  C  CA  . LEU A 1 109 ? -33.93458 32.21154 17.12705  1.000 26.38642 ? 109  LEU A CA  1 
ATOM   872  C  C   . LEU A 1 109 ? -34.71789 31.17582 17.92076  1.000 27.38423 ? 109  LEU A C   1 
ATOM   873  O  O   . LEU A 1 109 ? -35.44850 30.36792 17.33301  1.000 25.52870 ? 109  LEU A O   1 
ATOM   874  C  CB  . LEU A 1 109 ? -34.87022 33.32977 16.66636  1.000 26.47020 ? 109  LEU A CB  1 
ATOM   875  C  CG  . LEU A 1 109 ? -34.25267 34.51401 15.92371  1.000 27.36733 ? 109  LEU A CG  1 
ATOM   876  C  CD1 . LEU A 1 109 ? -35.31227 35.57667 15.65175  1.000 24.51121 ? 109  LEU A CD1 1 
ATOM   877  C  CD2 . LEU A 1 109 ? -33.10003 35.09091 16.72386  1.000 27.50971 ? 109  LEU A CD2 1 
ATOM   878  N  N   . ASP A 1 110 ? -34.57080 31.20294 19.25003  1.000 28.67299 ? 110  ASP A N   1 
ATOM   879  C  CA  . ASP A 1 110 ? -35.28330 30.26751 20.11271  1.000 31.88936 ? 110  ASP A CA  1 
ATOM   880  C  C   . ASP A 1 110 ? -36.74837 30.68869 20.23694  1.000 32.37320 ? 110  ASP A C   1 
ATOM   881  O  O   . ASP A 1 110 ? -37.17791 31.70053 19.67586  1.000 28.09700 ? 110  ASP A O   1 
ATOM   882  C  CB  . ASP A 1 110 ? -34.59769 30.15559 21.48127  1.000 34.92547 ? 110  ASP A CB  1 
ATOM   883  C  CG  . ASP A 1 110 ? -34.58853 31.47368 22.27581  1.000 35.83268 ? 110  ASP A CG  1 
ATOM   884  O  OD1 . ASP A 1 110 ? -35.41722 32.37019 22.02055  1.000 29.97628 ? 110  ASP A OD1 1 
ATOM   885  O  OD2 . ASP A 1 110 ? -33.72987 31.60670 23.17803  1.000 33.36716 ? 110  ASP A OD2 1 
ATOM   886  N  N   . LYS A 1 111 ? -37.52720 29.91618 21.00109  1.000 33.47461 ? 111  LYS A N   1 
ATOM   887  C  CA  . LYS A 1 111 ? -38.96790 30.15923 21.06791  1.000 37.40682 ? 111  LYS A CA  1 
ATOM   888  C  C   . LYS A 1 111 ? -39.30824 31.50767 21.69720  1.000 36.40046 ? 111  LYS A C   1 
ATOM   889  O  O   . LYS A 1 111 ? -40.40918 32.02791 21.47436  1.000 37.94659 ? 111  LYS A O   1 
ATOM   890  C  CB  . LYS A 1 111 ? -39.65227 29.02397 21.82727  1.000 35.88031 ? 111  LYS A CB  1 
ATOM   891  C  CG  . LYS A 1 111 ? -39.57610 27.67119 21.11869  1.000 42.43272 ? 111  LYS A CG  1 
ATOM   892  C  CD  . LYS A 1 111 ? -40.91976 27.25881 20.52319  1.000 47.87774 ? 111  LYS A CD  1 
ATOM   893  C  CE  . LYS A 1 111 ? -40.78885 26.02331 19.62948  1.000 38.45735 ? 111  LYS A CE  1 
ATOM   894  N  NZ  . LYS A 1 111 ? -41.76184 26.04932 18.48792  1.000 49.20362 ? 111  LYS A NZ  1 
ATOM   895  N  N   . GLU A 1 112 ? -38.38868 32.09733 22.45514  1.000 36.20637 ? 112  GLU A N   1 
ATOM   896  C  CA  . GLU A 1 112 ? -38.58667 33.42480 23.01619  1.000 31.48506 ? 112  GLU A CA  1 
ATOM   897  C  C   . GLU A 1 112 ? -38.04083 34.51820 22.11222  1.000 33.81683 ? 112  GLU A C   1 
ATOM   898  O  O   . GLU A 1 112 ? -38.03624 35.68543 22.51015  1.000 32.92677 ? 112  GLU A O   1 
ATOM   899  C  CB  . GLU A 1 112 ? -37.93641 33.52517 24.40797  1.000 40.12519 ? 112  GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 112 ? -38.26530 32.40423 25.42416  1.000 37.77675 ? 112  GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 112 ? -39.60633 31.70504 25.18484  1.000 58.66652 ? 112  GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 112 ? -40.66199 32.38931 25.20268  1.000 59.68013 ? 112  GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 112 ? -39.60211 30.46401 24.99944  1.000 58.31512 ? 112  GLU A OE2 1 
ATOM   904  N  N   . GLY A 1 113 ? -37.57050 34.16728 20.91302  1.000 31.41354 ? 113  GLY A N   1 
ATOM   905  C  CA  . GLY A 1 113 ? -37.05726 35.14569 19.97455  1.000 23.07324 ? 113  GLY A CA  1 
ATOM   906  C  C   . GLY A 1 113 ? -35.61796 35.55094 20.18919  1.000 26.17680 ? 113  GLY A C   1 
ATOM   907  O  O   . GLY A 1 113 ? -35.16528 36.52101 19.57096  1.000 31.20303 ? 113  GLY A O   1 
ATOM   908  N  N   . LYS A 1 114 ? -34.88681 34.84909 21.03986  1.000 30.41807 ? 114  LYS A N   1 
ATOM   909  C  CA  . LYS A 1 114 ? -33.50621 35.13973 21.38837  1.000 31.48107 ? 114  LYS A CA  1 
ATOM   910  C  C   . LYS A 1 114 ? -32.55077 34.29398 20.55043  1.000 31.05551 ? 114  LYS A C   1 
ATOM   911  O  O   . LYS A 1 114 ? -32.87997 33.16281 20.17627  1.000 30.06094 ? 114  LYS A O   1 
ATOM   912  C  CB  . LYS A 1 114 ? -33.26436 34.85991 22.87730  1.000 39.48485 ? 114  LYS A CB  1 
ATOM   913  C  CG  . LYS A 1 114 ? -33.87276 35.90203 23.82141  1.000 44.34308 ? 114  LYS A CG  1 
ATOM   914  C  CD  . LYS A 1 114 ? -33.04471 36.05454 25.08040  1.000 53.44339 ? 114  LYS A CD  1 
ATOM   915  C  CE  . LYS A 1 114 ? -31.72375 36.76891 24.77414  1.000 55.25757 ? 114  LYS A CE  1 
ATOM   916  N  NZ  . LYS A 1 114 ? -30.54505 36.11417 25.42092  1.000 56.48651 ? 114  LYS A NZ  1 
ATOM   917  N  N   . PRO A 1 115 ? -31.36498 34.81048 20.23031  1.000 29.21652 ? 115  PRO A N   1 
ATOM   918  C  CA  . PRO A 1 115 ? -30.38988 34.00843 19.47406  1.000 31.23542 ? 115  PRO A CA  1 
ATOM   919  C  C   . PRO A 1 115 ? -30.04429 32.71627 20.19680  1.000 35.43956 ? 115  PRO A C   1 
ATOM   920  O  O   . PRO A 1 115 ? -29.66353 32.72383 21.37049  1.000 37.41773 ? 115  PRO A O   1 
ATOM   921  C  CB  . PRO A 1 115 ? -29.17546 34.93641 19.36683  1.000 30.04857 ? 115  PRO A CB  1 
ATOM   922  C  CG  . PRO A 1 115 ? -29.75063 36.30316 19.43260  1.000 28.51676 ? 115  PRO A CG  1 
ATOM   923  C  CD  . PRO A 1 115 ? -30.92658 36.20813 20.38215  1.000 35.38253 ? 115  PRO A CD  1 
ATOM   924  N  N   . MET A 1 116 ? -30.17650 31.59719 19.47641  1.000 27.06791 ? 116  MET A N   1 
ATOM   925  C  CA  . MET A 1 116 ? -29.88253 30.29489 20.06558  1.000 28.01293 ? 116  MET A CA  1 
ATOM   926  C  C   . MET A 1 116 ? -28.41967 30.17349 20.47848  1.000 32.36519 ? 116  MET A C   1 
ATOM   927  O  O   . MET A 1 116 ? -28.09353 29.38997 21.37878  1.000 31.01384 ? 116  MET A O   1 
ATOM   928  C  CB  . MET A 1 116 ? -30.22149 29.17556 19.08367  1.000 23.17651 ? 116  MET A CB  1 
ATOM   929  C  CG  . MET A 1 116 ? -31.69764 28.96178 18.80113  1.000 26.55667 ? 116  MET A CG  1 
ATOM   930  S  SD  . MET A 1 116 ? -31.88635 27.67158 17.54796  1.000 23.40623 ? 116  MET A SD  1 
ATOM   931  C  CE  . MET A 1 116 ? -33.62522 27.27423 17.64977  1.000 24.42803 ? 116  MET A CE  1 
ATOM   932  N  N   . VAL A 1 117 ? -27.52087 30.91323 19.82240  1.000 28.89185 ? 117  VAL A N   1 
ATOM   933  C  CA  . VAL A 1 117 ? -26.10333 30.76527 20.12864  1.000 28.97636 ? 117  VAL A CA  1 
ATOM   934  C  C   . VAL A 1 117 ? -25.77964 31.27162 21.53123  1.000 33.70607 ? 117  VAL A C   1 
ATOM   935  O  O   . VAL A 1 117 ? -24.79443 30.82696 22.13202  1.000 34.79498 ? 117  VAL A O   1 
ATOM   936  C  CB  . VAL A 1 117 ? -25.23161 31.48641 19.08073  1.000 26.51851 ? 117  VAL A CB  1 
ATOM   937  C  CG1 . VAL A 1 117 ? -25.19327 30.69789 17.77059  1.000 23.87675 ? 117  VAL A CG1 1 
ATOM   938  C  CG2 . VAL A 1 117 ? -25.72372 32.90732 18.84725  1.000 28.79401 ? 117  VAL A CG2 1 
ATOM   939  N  N   . ASN A 1 118 ? -26.59643 32.17738 22.07755  1.000 34.14544 ? 118  ASN A N   1 
ATOM   940  C  CA  . ASN A 1 118 ? -26.37409 32.73292 23.40783  1.000 33.58719 ? 118  ASN A CA  1 
ATOM   941  C  C   . ASN A 1 118 ? -26.87778 31.84228 24.53487  1.000 40.42956 ? 118  ASN A C   1 
ATOM   942  O  O   . ASN A 1 118 ? -26.65824 32.17517 25.70334  1.000 43.93346 ? 118  ASN A O   1 
ATOM   943  C  CB  . ASN A 1 118 ? -27.04565 34.10101 23.52988  1.000 33.23904 ? 118  ASN A CB  1 
ATOM   944  C  CG  . ASN A 1 118 ? -26.56274 35.07937 22.48731  1.000 35.19162 ? 118  ASN A CG  1 
ATOM   945  O  OD1 . ASN A 1 118 ? -25.49698 34.89994 21.89167  1.000 43.37702 ? 118  ASN A OD1 1 
ATOM   946  N  ND2 . ASN A 1 118 ? -27.34609 36.12843 22.25586  1.000 34.97627 ? 118  ASN A ND2 1 
ATOM   947  N  N   . GLU A 1 119 ? -27.54431 30.73392 24.23531  1.000 35.74780 ? 119  GLU A N   1 
ATOM   948  C  CA  . GLU A 1 119 ? -28.08254 29.90292 25.30147  1.000 40.35748 ? 119  GLU A CA  1 
ATOM   949  C  C   . GLU A 1 119 ? -26.95816 29.18247 26.03415  1.000 39.21448 ? 119  GLU A C   1 
ATOM   950  O  O   . GLU A 1 119 ? -26.08840 28.56675 25.40893  1.000 37.43730 ? 119  GLU A O   1 
ATOM   951  C  CB  . GLU A 1 119 ? -29.07656 28.89043 24.74542  1.000 34.63532 ? 119  GLU A CB  1 
ATOM   952  C  CG  . GLU A 1 119 ? -29.75319 28.07504 25.82680  1.000 36.87979 ? 119  GLU A CG  1 
ATOM   953  C  CD  . GLU A 1 119 ? -30.39135 28.94776 26.89351  1.000 46.67222 ? 119  GLU A CD  1 
ATOM   954  O  OE1 . GLU A 1 119 ? -31.25624 29.77892 26.54691  1.000 45.57335 ? 119  GLU A OE1 1 
ATOM   955  O  OE2 . GLU A 1 119 ? -30.01943 28.81204 28.07939  1.000 48.00819 ? 119  GLU A OE2 1 
ATOM   956  N  N   . THR A 1 120 ? -26.98303 29.25579 27.36822  1.000 41.27711 ? 120  THR A N   1 
ATOM   957  C  CA  . THR A 1 120 ? -25.99227 28.58606 28.19896  1.000 42.05596 ? 120  THR A CA  1 
ATOM   958  C  C   . THR A 1 120 ? -26.52075 27.34844 28.90631  1.000 40.66101 ? 120  THR A C   1 
ATOM   959  O  O   . THR A 1 120 ? -25.71867 26.49422 29.29297  1.000 41.75001 ? 120  THR A O   1 
ATOM   960  C  CB  . THR A 1 120 ? -25.42823 29.55412 29.24901  1.000 43.29972 ? 120  THR A CB  1 
ATOM   961  O  OG1 . THR A 1 120 ? -26.50593 30.11984 30.00679  1.000 49.37941 ? 120  THR A OG1 1 
ATOM   962  C  CG2 . THR A 1 120 ? -24.64687 30.67697 28.57098  1.000 37.33160 ? 120  THR A CG2 1 
ATOM   963  N  N   . ASP A 1 121 ? -27.83015 27.22324 29.07558  1.000 42.25415 ? 121  ASP A N   1 
ATOM   964  C  CA  . ASP A 1 121 ? -28.40570 26.02681 29.68848  1.000 38.00588 ? 121  ASP A CA  1 
ATOM   965  C  C   . ASP A 1 121 ? -28.23672 24.83205 28.75548  1.000 43.62257 ? 121  ASP A C   1 
ATOM   966  O  O   . ASP A 1 121 ? -28.73665 24.86943 27.62432  1.000 44.72782 ? 121  ASP A O   1 
ATOM   967  C  CB  . ASP A 1 121 ? -29.88474 26.26331 29.99949  1.000 42.99277 ? 121  ASP A CB  1 
ATOM   968  C  CG  . ASP A 1 121 ? -30.50884 25.14098 30.82165  1.000 45.83260 ? 121  ASP A CG  1 
ATOM   969  O  OD1 . ASP A 1 121 ? -30.26320 23.94917 30.53599  1.000 48.98817 ? 121  ASP A OD1 1 
ATOM   970  O  OD2 . ASP A 1 121 ? -31.26378 25.45539 31.76291  1.000 56.74569 ? 121  ASP A OD2 1 
ATOM   971  N  N   . PRO A 1 122 ? -27.57015 23.75368 29.17927  1.000 42.50279 ? 122  PRO A N   1 
ATOM   972  C  CA  . PRO A 1 122 ? -27.38494 22.61641 28.26387  1.000 40.54368 ? 122  PRO A CA  1 
ATOM   973  C  C   . PRO A 1 122 ? -28.68153 21.92607 27.88289  1.000 44.01415 ? 122  PRO A C   1 
ATOM   974  O  O   . PRO A 1 122 ? -28.76499 21.36252 26.78328  1.000 37.95302 ? 122  PRO A O   1 
ATOM   975  C  CB  . PRO A 1 122 ? -26.44863 21.67872 29.04388  1.000 41.10959 ? 122  PRO A CB  1 
ATOM   976  C  CG  . PRO A 1 122 ? -26.60466 22.07682 30.46810  1.000 42.53025 ? 122  PRO A CG  1 
ATOM   977  C  CD  . PRO A 1 122 ? -26.88223 23.54977 30.46553  1.000 44.65751 ? 122  PRO A CD  1 
ATOM   978  N  N   . VAL A 1 123 ? -29.69496 21.94902 28.75041  1.000 40.75187 ? 123  VAL A N   1 
ATOM   979  C  CA  . VAL A 1 123 ? -30.97015 21.33101 28.40187  1.000 35.33496 ? 123  VAL A CA  1 
ATOM   980  C  C   . VAL A 1 123 ? -31.70625 22.17773 27.36676  1.000 37.56311 ? 123  VAL A C   1 
ATOM   981  O  O   . VAL A 1 123 ? -32.34319 21.64834 26.44858  1.000 35.90310 ? 123  VAL A O   1 
ATOM   982  C  CB  . VAL A 1 123 ? -31.81694 21.10030 29.66964  1.000 47.59646 ? 123  VAL A CB  1 
ATOM   983  C  CG1 . VAL A 1 123 ? -33.29307 20.90557 29.31599  1.000 37.87727 ? 123  VAL A CG1 1 
ATOM   984  C  CG2 . VAL A 1 123 ? -31.28864 19.89616 30.44802  1.000 43.31767 ? 123  VAL A CG2 1 
ATOM   985  N  N   . LYS A 1 124 ? -31.62561 23.50292 27.49020  1.000 35.89504 ? 124  LYS A N   1 
ATOM   986  C  CA  . LYS A 1 124 ? -32.21134 24.36874 26.47464  1.000 35.69852 ? 124  LYS A CA  1 
ATOM   987  C  C   . LYS A 1 124 ? -31.39886 24.32455 25.18511  1.000 40.54125 ? 124  LYS A C   1 
ATOM   988  O  O   . LYS A 1 124 ? -31.96387 24.37078 24.08523  1.000 34.30217 ? 124  LYS A O   1 
ATOM   989  C  CB  . LYS A 1 124 ? -32.31422 25.79824 26.99924  1.000 35.35763 ? 124  LYS A CB  1 
ATOM   990  C  CG  . LYS A 1 124 ? -33.12283 25.92861 28.27351  1.000 48.04061 ? 124  LYS A CG  1 
ATOM   991  C  CD  . LYS A 1 124 ? -33.99636 27.17571 28.23829  1.000 47.67790 ? 124  LYS A CD  1 
ATOM   992  C  CE  . LYS A 1 124 ? -34.41119 27.60812 29.63905  1.000 55.98392 ? 124  LYS A CE  1 
ATOM   993  N  NZ  . LYS A 1 124 ? -34.21914 29.07335 29.85560  1.000 57.65433 ? 124  LYS A NZ  1 
ATOM   994  N  N   . ARG A 1 125 ? -30.07171 24.24232 25.30029  1.000 32.72557 ? 125  ARG A N   1 
ATOM   995  C  CA  . ARG A 1 125 ? -29.24409 24.10130 24.11183  1.000 31.76357 ? 125  ARG A CA  1 
ATOM   996  C  C   . ARG A 1 125 ? -29.66480 22.88257 23.30738  1.000 33.12150 ? 125  ARG A C   1 
ATOM   997  O  O   . ARG A 1 125 ? -29.76170 22.94518 22.07624  1.000 31.15397 ? 125  ARG A O   1 
ATOM   998  C  CB  . ARG A 1 125 ? -27.76920 24.01160 24.50041  1.000 30.04074 ? 125  ARG A CB  1 
ATOM   999  C  CG  . ARG A 1 125 ? -27.14932 25.34540 24.88380  1.000 38.36635 ? 125  ARG A CG  1 
ATOM   1000 C  CD  . ARG A 1 125 ? -25.63721 25.27655 24.83839  1.000 38.10745 ? 125  ARG A CD  1 
ATOM   1001 N  NE  . ARG A 1 125 ? -25.13871 25.19611 23.46873  1.000 35.97956 ? 125  ARG A NE  1 
ATOM   1002 C  CZ  . ARG A 1 125 ? -25.00580 26.24644 22.66450  1.000 37.84213 ? 125  ARG A CZ  1 
ATOM   1003 N  NH1 . ARG A 1 125 ? -25.34189 27.45969 23.08905  1.000 33.05061 ? 125  ARG A NH1 1 
ATOM   1004 N  NH2 . ARG A 1 125 ? -24.53331 26.08670 21.43480  1.000 39.43427 ? 125  ARG A NH2 1 
ATOM   1005 N  N   . GLU A 1 126 ? -29.95019 21.77266 23.98935  1.000 31.96249 ? 126  GLU A N   1 
ATOM   1006 C  CA  . GLU A 1 126 ? -30.39344 20.57767 23.28446  1.000 35.05567 ? 126  GLU A CA  1 
ATOM   1007 C  C   . GLU A 1 126 ? -31.75788 20.78940 22.64555  1.000 35.14090 ? 126  GLU A C   1 
ATOM   1008 O  O   . GLU A 1 126 ? -32.00260 20.32223 21.52542  1.000 29.85383 ? 126  GLU A O   1 
ATOM   1009 C  CB  . GLU A 1 126 ? -30.42802 19.37940 24.22977  1.000 31.74895 ? 126  GLU A CB  1 
ATOM   1010 C  CG  . GLU A 1 126 ? -30.94466 18.10200 23.57659  1.000 30.76204 ? 126  GLU A CG  1 
ATOM   1011 C  CD  . GLU A 1 126 ? -30.04299 17.59873 22.45603  1.000 40.33393 ? 126  GLU A CD  1 
ATOM   1012 O  OE1 . GLU A 1 126 ? -28.87794 18.05473 22.36156  1.000 40.09659 ? 126  GLU A OE1 1 
ATOM   1013 O  OE2 . GLU A 1 126 ? -30.49916 16.73946 21.66616  1.000 38.93768 ? 126  GLU A OE2 1 
ATOM   1014 N  N   . GLN A 1 127 ? -32.66116 21.48903 23.33607  1.000 31.97699 ? 127  GLN A N   1 
ATOM   1015 C  CA  . GLN A 1 127 ? -33.95467 21.78134 22.72618  1.000 36.26173 ? 127  GLN A CA  1 
ATOM   1016 C  C   . GLN A 1 127 ? -33.78910 22.67904 21.50460  1.000 30.75220 ? 127  GLN A C   1 
ATOM   1017 O  O   . GLN A 1 127 ? -34.50042 22.51840 20.50655  1.000 25.86215 ? 127  GLN A O   1 
ATOM   1018 C  CB  . GLN A 1 127 ? -34.89404 22.42611 23.74834  1.000 34.50479 ? 127  GLN A CB  1 
ATOM   1019 C  CG  . GLN A 1 127 ? -35.29936 21.50222 24.89071  1.000 36.46248 ? 127  GLN A CG  1 
ATOM   1020 C  CD  . GLN A 1 127 ? -36.07712 22.23037 25.96748  1.000 44.77873 ? 127  GLN A CD  1 
ATOM   1021 O  OE1 . GLN A 1 127 ? -35.77849 23.38076 26.29173  1.000 50.18784 ? 127  GLN A OE1 1 
ATOM   1022 N  NE2 . GLN A 1 127 ? -37.07427 21.56162 26.53558  1.000 48.08080 ? 127  GLN A NE2 1 
ATOM   1023 N  N   . ASN A 1 128 ? -32.84985 23.62347 21.55991  1.000 26.86739 ? 128  ASN A N   1 
ATOM   1024 C  CA  . ASN A 1 128 ? -32.62085 24.48356 20.40915  1.000 27.93177 ? 128  ASN A CA  1 
ATOM   1025 C  C   . ASN A 1 128 ? -32.04818 23.69174 19.24257  1.000 28.65037 ? 128  ASN A C   1 
ATOM   1026 O  O   . ASN A 1 128 ? -32.39988 23.94218 18.08374  1.000 22.27735 ? 128  ASN A O   1 
ATOM   1027 C  CB  . ASN A 1 128 ? -31.69915 25.63293 20.79140  1.000 29.64225 ? 128  ASN A CB  1 
ATOM   1028 C  CG  . ASN A 1 128 ? -32.40041 26.67060 21.62598  1.000 30.96105 ? 128  ASN A CG  1 
ATOM   1029 O  OD1 . ASN A 1 128 ? -33.62617 26.68199 21.70965  1.000 34.78647 ? 128  ASN A OD1 1 
ATOM   1030 N  ND2 . ASN A 1 128 ? -31.63274 27.55753 22.23950  1.000 29.74790 ? 128  ASN A ND2 1 
ATOM   1031 N  N   . LYS A 1 129 ? -31.17816 22.72101 19.52917  1.000 28.41729 ? 129  LYS A N   1 
ATOM   1032 C  CA  . LYS A 1 129 ? -30.64934 21.87727 18.46547  1.000 28.35096 ? 129  LYS A CA  1 
ATOM   1033 C  C   . LYS A 1 129 ? -31.77429 21.14903 17.74283  1.000 29.43601 ? 129  LYS A C   1 
ATOM   1034 O  O   . LYS A 1 129 ? -31.85053 21.16317 16.50909  1.000 24.52672 ? 129  LYS A O   1 
ATOM   1035 C  CB  . LYS A 1 129 ? -29.64777 20.87573 19.03177  1.000 21.64385 ? 129  LYS A CB  1 
ATOM   1036 C  CG  . LYS A 1 129 ? -29.32706 19.75985 18.06402  1.000 20.56223 ? 129  LYS A CG  1 
ATOM   1037 C  CD  . LYS A 1 129 ? -28.20931 18.87912 18.59113  1.000 28.23530 ? 129  LYS A CD  1 
ATOM   1038 C  CE  . LYS A 1 129 ? -27.96435 17.68557 17.67712  1.000 31.39210 ? 129  LYS A CE  1 
ATOM   1039 N  NZ  . LYS A 1 129 ? -26.84444 16.83673 18.19233  1.000 31.67512 ? 129  LYS A NZ  1 
ATOM   1040 N  N   . GLN A 1 130 ? -32.66653 20.51409 18.50269  1.000 23.57245 ? 130  GLN A N   1 
ATOM   1041 C  CA  . GLN A 1 130 ? -33.73954 19.74091 17.89420  1.000 23.59501 ? 130  GLN A CA  1 
ATOM   1042 C  C   . GLN A 1 130 ? -34.70279 20.63805 17.12785  1.000 22.43939 ? 130  GLN A C   1 
ATOM   1043 O  O   . GLN A 1 130 ? -35.21521 20.25051 16.07042  1.000 22.30631 ? 130  GLN A O   1 
ATOM   1044 C  CB  . GLN A 1 130 ? -34.47336 18.94418 18.97516  1.000 32.86080 ? 130  GLN A CB  1 
ATOM   1045 C  CG  . GLN A 1 130 ? -33.57852 17.95938 19.70047  1.000 29.20425 ? 130  GLN A CG  1 
ATOM   1046 C  CD  . GLN A 1 130 ? -32.99224 16.93475 18.74718  1.000 35.53201 ? 130  GLN A CD  1 
ATOM   1047 O  OE1 . GLN A 1 130 ? -33.62809 16.56584 17.75869  1.000 35.30556 ? 130  GLN A OE1 1 
ATOM   1048 N  NE2 . GLN A 1 130 ? -31.77415 16.47768 19.02990  1.000 36.20802 ? 130  GLN A NE2 1 
ATOM   1049 N  N   . LEU A 1 131 ? -34.95884 21.83893 17.64280  1.000 21.17928 ? 131  LEU A N   1 
ATOM   1050 C  CA  . LEU A 1 131 ? -35.80017 22.78749 16.92751  1.000 22.91289 ? 131  LEU A CA  1 
ATOM   1051 C  C   . LEU A 1 131 ? -35.14723 23.23314 15.61877  1.000 23.35520 ? 131  LEU A C   1 
ATOM   1052 O  O   . LEU A 1 131 ? -35.80044 23.26270 14.56726  1.000 20.58285 ? 131  LEU A O   1 
ATOM   1053 C  CB  . LEU A 1 131 ? -36.09836 23.98674 17.82303  1.000 19.16762 ? 131  LEU A CB  1 
ATOM   1054 C  CG  . LEU A 1 131 ? -36.99362 25.05720 17.20773  1.000 23.60629 ? 131  LEU A CG  1 
ATOM   1055 C  CD1 . LEU A 1 131 ? -38.32313 24.45264 16.77716  1.000 19.59865 ? 131  LEU A CD1 1 
ATOM   1056 C  CD2 . LEU A 1 131 ? -37.19085 26.21887 18.18245  1.000 26.27776 ? 131  LEU A CD2 1 
ATOM   1057 N  N   . LEU A 1 132 ? -33.86031 23.59565 15.66490  1.000 23.40078 ? 132  LEU A N   1 
ATOM   1058 C  CA  . LEU A 1 132 ? -33.15699 23.97596 14.44090  1.000 17.69816 ? 132  LEU A CA  1 
ATOM   1059 C  C   . LEU A 1 132 ? -33.16250 22.83779 13.42921  1.000 17.88216 ? 132  LEU A C   1 
ATOM   1060 O  O   . LEU A 1 132 ? -33.38209 23.06027 12.23250  1.000 19.36495 ? 132  LEU A O   1 
ATOM   1061 C  CB  . LEU A 1 132 ? -31.72127 24.39337 14.75771  1.000 20.20914 ? 132  LEU A CB  1 
ATOM   1062 C  CG  . LEU A 1 132 ? -30.91140 24.84722 13.53549  1.000 16.33955 ? 132  LEU A CG  1 
ATOM   1063 C  CD1 . LEU A 1 132 ? -31.60458 26.01810 12.86867  1.000 16.47075 ? 132  LEU A CD1 1 
ATOM   1064 C  CD2 . LEU A 1 132 ? -29.48967 25.22969 13.92544  1.000 17.11039 ? 132  LEU A CD2 1 
ATOM   1065 N  N   . LEU A 1 133 ? -32.92596 21.60874 13.89241  1.000 17.76154 ? 133  LEU A N   1 
ATOM   1066 C  CA  . LEU A 1 133 ? -32.91228 20.47266 12.98404  1.000 16.29820 ? 133  LEU A CA  1 
ATOM   1067 C  C   . LEU A 1 133 ? -34.29429 20.21919 12.40094  1.000 23.32766 ? 133  LEU A C   1 
ATOM   1068 O  O   . LEU A 1 133 ? -34.41310 19.82458 11.23239  1.000 18.54534 ? 133  LEU A O   1 
ATOM   1069 C  CB  . LEU A 1 133 ? -32.37870 19.23414 13.70127  1.000 22.66745 ? 133  LEU A CB  1 
ATOM   1070 C  CG  . LEU A 1 133 ? -30.88399 19.31704 14.03860  1.000 22.17485 ? 133  LEU A CG  1 
ATOM   1071 C  CD1 . LEU A 1 133 ? -30.44120 18.11264 14.86486  1.000 22.92376 ? 133  LEU A CD1 1 
ATOM   1072 C  CD2 . LEU A 1 133 ? -30.04170 19.43808 12.75890  1.000 17.86707 ? 133  LEU A CD2 1 
ATOM   1073 N  N   . LYS A 1 134 ? -35.35350 20.43309 13.19651  1.000 22.78938 ? 134  LYS A N   1 
ATOM   1074 C  CA  . LYS A 1 134 ? -36.70143 20.29233 12.65922  1.000 18.41943 ? 134  LYS A CA  1 
ATOM   1075 C  C   . LYS A 1 134 ? -36.95537 21.34348 11.58308  1.000 18.15363 ? 134  LYS A C   1 
ATOM   1076 O  O   . LYS A 1 134 ? -37.45077 21.02908 10.49445  1.000 17.71174 ? 134  LYS A O   1 
ATOM   1077 C  CB  . LYS A 1 134 ? -37.74362 20.37901 13.78212  1.000 18.38627 ? 134  LYS A CB  1 
ATOM   1078 C  CG  . LYS A 1 134 ? -39.12126 19.85171 13.37899  1.000 25.74203 ? 134  LYS A CG  1 
ATOM   1079 C  CD  . LYS A 1 134 ? -40.24657 20.32956 14.32185  1.000 36.20557 ? 134  LYS A CD  1 
ATOM   1080 C  CE  . LYS A 1 134 ? -41.57150 19.59156 14.03804  1.000 37.34546 ? 134  LYS A CE  1 
ATOM   1081 N  NZ  . LYS A 1 134 ? -41.66921 19.11193 12.60688  1.000 47.16652 ? 134  LYS A NZ  1 
ATOM   1082 N  N   . ARG A 1 135 ? -36.58721 22.59633 11.85507  1.000 15.76103 ? 135  ARG A N   1 
ATOM   1083 C  CA  . ARG A 1 135 ? -36.74880 23.64607 10.85012  1.000 14.83693 ? 135  ARG A CA  1 
ATOM   1084 C  C   . ARG A 1 135 ? -35.94863 23.33030 9.59185   1.000 16.84463 ? 135  ARG A C   1 
ATOM   1085 O  O   . ARG A 1 135 ? -36.43466 23.52293 8.47108   1.000 13.10381 ? 135  ARG A O   1 
ATOM   1086 C  CB  . ARG A 1 135 ? -36.32091 24.99601 11.42629  1.000 17.10089 ? 135  ARG A CB  1 
ATOM   1087 C  CG  . ARG A 1 135 ? -37.20620 25.49209 12.56511  1.000 18.20654 ? 135  ARG A CG  1 
ATOM   1088 C  CD  . ARG A 1 135 ? -36.54189 26.62277 13.31779  1.000 18.25698 ? 135  ARG A CD  1 
ATOM   1089 N  NE  . ARG A 1 135 ? -37.48873 27.32728 14.17610  1.000 23.80883 ? 135  ARG A NE  1 
ATOM   1090 C  CZ  . ARG A 1 135 ? -37.15002 28.28447 15.03522  1.000 24.27430 ? 135  ARG A CZ  1 
ATOM   1091 N  NH1 . ARG A 1 135 ? -35.87916 28.64709 15.15714  1.000 21.89870 ? 135  ARG A NH1 1 
ATOM   1092 N  NH2 . ARG A 1 135 ? -38.08108 28.87894 15.77346  1.000 19.24992 ? 135  ARG A NH2 1 
ATOM   1093 N  N   . LEU A 1 136 ? -34.72124 22.84493 9.76285   1.000 15.49203 ? 136  LEU A N   1 
ATOM   1094 C  CA  . LEU A 1 136 ? -33.90377 22.45110 8.62232   1.000 17.39896 ? 136  LEU A CA  1 
ATOM   1095 C  C   . LEU A 1 136 ? -34.60164 21.39268 7.78461   1.000 14.00056 ? 136  LEU A C   1 
ATOM   1096 O  O   . LEU A 1 136 ? -34.64825 21.48762 6.55215   1.000 15.13437 ? 136  LEU A O   1 
ATOM   1097 C  CB  . LEU A 1 136 ? -32.55369 21.92931 9.10713   1.000 16.91141 ? 136  LEU A CB  1 
ATOM   1098 C  CG  . LEU A 1 136 ? -31.65278 21.33756 8.02092   1.000 16.99285 ? 136  LEU A CG  1 
ATOM   1099 C  CD1 . LEU A 1 136 ? -31.39571 22.38438 6.95483   1.000 12.88909 ? 136  LEU A CD1 1 
ATOM   1100 C  CD2 . LEU A 1 136 ? -30.33818 20.83739 8.62488   1.000 16.87304 ? 136  LEU A CD2 1 
ATOM   1101 N  N   . GLU A 1 137 ? -35.13147 20.35638 8.43507   1.000 14.39996 ? 137  GLU A N   1 
ATOM   1102 C  CA  . GLU A 1 137 ? -35.78933 19.29497 7.68260   1.000 17.36120 ? 137  GLU A CA  1 
ATOM   1103 C  C   . GLU A 1 137 ? -37.00329 19.82136 6.92142   1.000 15.83705 ? 137  GLU A C   1 
ATOM   1104 O  O   . GLU A 1 137 ? -37.24815 19.41731 5.77648   1.000 12.64327 ? 137  GLU A O   1 
ATOM   1105 C  CB  . GLU A 1 137 ? -36.20010 18.15421 8.60732   1.000 18.45391 ? 137  GLU A CB  1 
ATOM   1106 C  CG  . GLU A 1 137 ? -36.74632 16.97811 7.82700   1.000 32.44826 ? 137  GLU A CG  1 
ATOM   1107 C  CD  . GLU A 1 137 ? -37.28938 15.88529 8.70624   1.000 41.54765 ? 137  GLU A CD  1 
ATOM   1108 O  OE1 . GLU A 1 137 ? -36.64484 15.57158 9.73028   1.000 50.86458 ? 137  GLU A OE1 1 
ATOM   1109 O  OE2 . GLU A 1 137 ? -38.35965 15.33270 8.36310   1.000 45.39120 ? 137  GLU A OE2 1 
ATOM   1110 N  N   . THR A 1 138 ? -37.76729 20.73329 7.53098   1.000 13.50340 ? 138  THR A N   1 
ATOM   1111 C  CA  . THR A 1 138 ? -38.97463 21.22939 6.86788   1.000 14.34550 ? 138  THR A CA  1 
ATOM   1112 C  C   . THR A 1 138 ? -38.63049 22.07811 5.64773   1.000 17.03012 ? 138  THR A C   1 
ATOM   1113 O  O   . THR A 1 138 ? -39.31650 22.00255 4.61856   1.000 13.31363 ? 138  THR A O   1 
ATOM   1114 C  CB  . THR A 1 138 ? -39.82191 22.04284 7.84495   1.000 16.60376 ? 138  THR A CB  1 
ATOM   1115 O  OG1 . THR A 1 138 ? -40.21933 21.21145 8.93537   1.000 18.54810 ? 138  THR A OG1 1 
ATOM   1116 C  CG2 . THR A 1 138 ? -41.06439 22.56724 7.16001   1.000 12.10653 ? 138  THR A CG2 1 
ATOM   1117 N  N   . HIS A 1 139 ? -37.60093 22.92831 5.76999   1.000 14.01183 ? 139  HIS A N   1 
ATOM   1118 C  CA  . HIS A 1 139 ? -37.09817 23.70943 4.64101   1.000 13.34955 ? 139  HIS A CA  1 
ATOM   1119 C  C   . HIS A 1 139 ? -36.69920 22.79486 3.48500   1.000 13.00913 ? 139  HIS A C   1 
ATOM   1120 O  O   . HIS A 1 139 ? -37.15278 22.97392 2.35026   1.000 11.94061 ? 139  HIS A O   1 
ATOM   1121 C  CB  . HIS A 1 139 ? -35.91236 24.56168 5.11906   1.000 13.23992 ? 139  HIS A CB  1 
ATOM   1122 C  CG  . HIS A 1 139 ? -35.24972 25.37881 4.04721   1.000 16.65326 ? 139  HIS A CG  1 
ATOM   1123 N  ND1 . HIS A 1 139 ? -35.70213 26.62694 3.67285   1.000 12.79592 ? 139  HIS A ND1 1 
ATOM   1124 C  CD2 . HIS A 1 139 ? -34.14047 25.14270 3.30225   1.000 14.61303 ? 139  HIS A CD2 1 
ATOM   1125 C  CE1 . HIS A 1 139 ? -34.91180 27.11679 2.73209   1.000 14.88423 ? 139  HIS A CE1 1 
ATOM   1126 N  NE2 . HIS A 1 139 ? -33.95089 26.23958 2.49576   1.000 12.53433 ? 139  HIS A NE2 1 
ATOM   1127 N  N   . ILE A 1 140 ? -35.88327 21.77828 3.77072   1.000 11.64407 ? 140  ILE A N   1 
ATOM   1128 C  CA  . ILE A 1 140 ? -35.44854 20.83606 2.73955   1.000 10.77142 ? 140  ILE A CA  1 
ATOM   1129 C  C   . ILE A 1 140 ? -36.62415 20.02854 2.20959   1.000 16.04405 ? 140  ILE A C   1 
ATOM   1130 O  O   . ILE A 1 140 ? -36.74854 19.81268 0.99475   1.000 14.35866 ? 140  ILE A O   1 
ATOM   1131 C  CB  . ILE A 1 140 ? -34.33741 19.92393 3.29807   1.000 14.12897 ? 140  ILE A CB  1 
ATOM   1132 C  CG1 . ILE A 1 140 ? -33.07101 20.74552 3.54932   1.000 12.54457 ? 140  ILE A CG1 1 
ATOM   1133 C  CG2 . ILE A 1 140 ? -34.05652 18.74346 2.35128   1.000 9.18481  ? 140  ILE A CG2 1 
ATOM   1134 C  CD1 . ILE A 1 140 ? -31.99401 19.98192 4.25447   1.000 14.86816 ? 140  ILE A CD1 1 
ATOM   1135 N  N   . LYS A 1 141 ? -37.49583 19.55559 3.11190   1.000 13.95297 ? 141  LYS A N   1 
ATOM   1136 C  CA  . LYS A 1 141 ? -38.64924 18.75880 2.70292   1.000 12.19421 ? 141  LYS A CA  1 
ATOM   1137 C  C   . LYS A 1 141 ? -39.48781 19.50240 1.67692   1.000 11.59851 ? 141  LYS A C   1 
ATOM   1138 O  O   . LYS A 1 141 ? -39.82065 18.96017 0.61862   1.000 12.46468 ? 141  LYS A O   1 
ATOM   1139 C  CB  . LYS A 1 141 ? -39.49660 18.40568 3.93024   1.000 11.33236 ? 141  LYS A CB  1 
ATOM   1140 C  CG  . LYS A 1 141 ? -40.84957 17.73259 3.62438   1.000 12.49284 ? 141  LYS A CG  1 
ATOM   1141 C  CD  . LYS A 1 141 ? -41.64712 17.51815 4.92299   1.000 12.19574 ? 141  LYS A CD  1 
ATOM   1142 C  CE  . LYS A 1 141 ? -43.02312 16.91747 4.65390   1.000 15.60208 ? 141  LYS A CE  1 
ATOM   1143 N  NZ  . LYS A 1 141 ? -43.88340 17.89274 3.92186   1.000 12.23117 ? 141  LYS A NZ  1 
ATOM   1144 N  N   . THR A 1 142 ? -39.83333 20.75356 1.97921   1.000 10.48895 ? 142  THR A N   1 
ATOM   1145 C  CA  . THR A 1 142 ? -40.71178 21.52876 1.11030   1.000 11.08810 ? 142  THR A CA  1 
ATOM   1146 C  C   . THR A 1 142 ? -40.07258 21.76144 -0.25502  1.000 13.02218 ? 142  THR A C   1 
ATOM   1147 O  O   . THR A 1 142 ? -40.73072 21.61856 -1.29552  1.000 8.85705  ? 142  THR A O   1 
ATOM   1148 C  CB  . THR A 1 142 ? -41.04798 22.86203 1.78673   1.000 13.81143 ? 142  THR A CB  1 
ATOM   1149 O  OG1 . THR A 1 142 ? -41.56183 22.60975 3.10054   1.000 15.89034 ? 142  THR A OG1 1 
ATOM   1150 C  CG2 . THR A 1 142 ? -42.09090 23.63988 0.99465   1.000 11.54072 ? 142  THR A CG2 1 
ATOM   1151 N  N   . ILE A 1 143 ? -38.78573 22.11212 -0.27234  1.000 14.58341 ? 143  ILE A N   1 
ATOM   1152 C  CA  . ILE A 1 143 ? -38.09733 22.35283 -1.53869  1.000 13.70903 ? 143  ILE A CA  1 
ATOM   1153 C  C   . ILE A 1 143 ? -38.01227 21.06685 -2.35912  1.000 11.97512 ? 143  ILE A C   1 
ATOM   1154 O  O   . ILE A 1 143 ? -38.31101 21.04413 -3.56035  1.000 11.61811 ? 143  ILE A O   1 
ATOM   1155 C  CB  . ILE A 1 143 ? -36.69845 22.93885 -1.27401  1.000 11.90956 ? 143  ILE A CB  1 
ATOM   1156 C  CG1 . ILE A 1 143 ? -36.81294 24.34258 -0.66348  1.000 11.80649 ? 143  ILE A CG1 1 
ATOM   1157 C  CG2 . ILE A 1 143 ? -35.87701 22.91184 -2.55527  1.000 12.48732 ? 143  ILE A CG2 1 
ATOM   1158 C  CD1 . ILE A 1 143 ? -35.49104 24.85457 -0.07331  1.000 12.35121 ? 143  ILE A CD1 1 
ATOM   1159 N  N   . VAL A 1 144 ? -37.58857 19.97681 -1.72638  1.000 14.19104 ? 144  VAL A N   1 
ATOM   1160 C  CA  . VAL A 1 144 ? -37.34035 18.75374 -2.47709  1.000 11.60418 ? 144  VAL A CA  1 
ATOM   1161 C  C   . VAL A 1 144 ? -38.65577 18.11493 -2.92404  1.000 17.20973 ? 144  VAL A C   1 
ATOM   1162 O  O   . VAL A 1 144 ? -38.74701 17.55213 -4.02402  1.000 11.32535 ? 144  VAL A O   1 
ATOM   1163 C  CB  . VAL A 1 144 ? -36.47514 17.80066 -1.63358  1.000 18.62599 ? 144  VAL A CB  1 
ATOM   1164 C  CG1 . VAL A 1 144 ? -36.44869 16.46105 -2.25241  1.000 15.82706 ? 144  VAL A CG1 1 
ATOM   1165 C  CG2 . VAL A 1 144 ? -35.03944 18.34943 -1.51703  1.000 13.15837 ? 144  VAL A CG2 1 
ATOM   1166 N  N   . GLU A 1 145 ? -39.70533 18.21038 -2.09896  1.000 12.96081 ? 145  GLU A N   1 
ATOM   1167 C  CA  . GLU A 1 145 ? -41.01114 17.71266 -2.53762  1.000 12.36674 ? 145  GLU A CA  1 
ATOM   1168 C  C   . GLU A 1 145 ? -41.50328 18.44626 -3.78132  1.000 11.20832 ? 145  GLU A C   1 
ATOM   1169 O  O   . GLU A 1 145 ? -42.19203 17.85128 -4.61504  1.000 13.49315 ? 145  GLU A O   1 
ATOM   1170 C  CB  . GLU A 1 145 ? -42.03554 17.81732 -1.39238  1.000 11.12396 ? 145  GLU A CB  1 
ATOM   1171 C  CG  . GLU A 1 145 ? -41.83063 16.72366 -0.34451  1.000 12.35404 ? 145  GLU A CG  1 
ATOM   1172 C  CD  . GLU A 1 145 ? -42.80750 16.81364 0.81333   1.000 14.44979 ? 145  GLU A CD  1 
ATOM   1173 O  OE1 . GLU A 1 145 ? -43.22570 17.93324 1.15438   1.000 14.30416 ? 145  GLU A OE1 1 
ATOM   1174 O  OE2 . GLU A 1 145 ? -43.15220 15.75849 1.37836   1.000 12.19504 ? 145  GLU A OE2 1 
ATOM   1175 N  N   . ARG A 1 146 ? -41.13946 19.72200 -3.94550  1.000 12.36308 ? 146  ARG A N   1 
ATOM   1176 C  CA  . ARG A 1 146 ? -41.55300 20.44592 -5.14596  1.000 10.64598 ? 146  ARG A CA  1 
ATOM   1177 C  C   . ARG A 1 146 ? -40.71422 20.07507 -6.37514  1.000 12.25151 ? 146  ARG A C   1 
ATOM   1178 O  O   . ARG A 1 146 ? -41.26132 19.95777 -7.47811  1.000 12.07937 ? 146  ARG A O   1 
ATOM   1179 C  CB  . ARG A 1 146 ? -41.49458 21.95651 -4.90288  1.000 13.64160 ? 146  ARG A CB  1 
ATOM   1180 C  CG  . ARG A 1 146 ? -42.01663 22.80896 -6.06720  1.000 12.29161 ? 146  ARG A CG  1 
ATOM   1181 C  CD  . ARG A 1 146 ? -42.12662 24.26979 -5.64922  1.000 15.21651 ? 146  ARG A CD  1 
ATOM   1182 N  NE  . ARG A 1 146 ? -42.69701 25.14236 -6.68316  1.000 10.80520 ? 146  ARG A NE  1 
ATOM   1183 C  CZ  . ARG A 1 146 ? -44.00105 25.36404 -6.82119  1.000 15.34390 ? 146  ARG A CZ  1 
ATOM   1184 N  NH1 . ARG A 1 146 ? -44.85515 24.76896 -5.99778  1.000 11.78257 ? 146  ARG A NH1 1 
ATOM   1185 N  NH2 . ARG A 1 146 ? -44.45187 26.17562 -7.76697  1.000 13.84625 ? 146  ARG A NH2 1 
ATOM   1186 N  N   . TYR A 1 147 ? -39.39774 19.87554 -6.22220  1.000 11.89018 ? 147  TYR A N   1 
ATOM   1187 C  CA  . TYR A 1 147 ? -38.49068 19.83320 -7.37367  1.000 14.19086 ? 147  TYR A CA  1 
ATOM   1188 C  C   . TYR A 1 147 ? -37.85141 18.47486 -7.64316  1.000 17.40944 ? 147  TYR A C   1 
ATOM   1189 O  O   . TYR A 1 147 ? -37.04351 18.37355 -8.57254  1.000 14.09346 ? 147  TYR A O   1 
ATOM   1190 C  CB  . TYR A 1 147 ? -37.36520 20.86506 -7.20391  1.000 10.66601 ? 147  TYR A CB  1 
ATOM   1191 C  CG  . TYR A 1 147 ? -37.82415 22.30600 -7.26356  1.000 14.51816 ? 147  TYR A CG  1 
ATOM   1192 C  CD1 . TYR A 1 147 ? -38.67452 22.75541 -8.27885  1.000 12.70521 ? 147  TYR A CD1 1 
ATOM   1193 C  CD2 . TYR A 1 147 ? -37.42371 23.20820 -6.30034  1.000 13.34279 ? 147  TYR A CD2 1 
ATOM   1194 C  CE1 . TYR A 1 147 ? -39.09407 24.07000 -8.32602  1.000 10.51517 ? 147  TYR A CE1 1 
ATOM   1195 C  CE2 . TYR A 1 147 ? -37.83640 24.52973 -6.33783  1.000 16.33807 ? 147  TYR A CE2 1 
ATOM   1196 C  CZ  . TYR A 1 147 ? -38.67171 24.95193 -7.34992  1.000 13.92306 ? 147  TYR A CZ  1 
ATOM   1197 O  OH  . TYR A 1 147 ? -39.07631 26.26821 -7.36817  1.000 15.60853 ? 147  TYR A OH  1 
ATOM   1198 N  N   . LYS A 1 148 ? -38.19111 17.43104 -6.88014  1.000 16.26602 ? 148  LYS A N   1 
ATOM   1199 C  CA  . LYS A 1 148 ? -37.47514 16.15723 -6.99085  1.000 18.60684 ? 148  LYS A CA  1 
ATOM   1200 C  C   . LYS A 1 148 ? -37.55595 15.55426 -8.38860  1.000 17.20086 ? 148  LYS A C   1 
ATOM   1201 O  O   . LYS A 1 148 ? -36.64595 14.82789 -8.79298  1.000 19.03653 ? 148  LYS A O   1 
ATOM   1202 C  CB  . LYS A 1 148 ? -38.01412 15.15251 -5.96951  1.000 18.13128 ? 148  LYS A CB  1 
ATOM   1203 C  CG  . LYS A 1 148 ? -39.46350 14.75690 -6.18700  1.000 16.11316 ? 148  LYS A CG  1 
ATOM   1204 C  CD  . LYS A 1 148 ? -39.97500 13.95152 -4.99429  1.000 24.83891 ? 148  LYS A CD  1 
ATOM   1205 C  CE  . LYS A 1 148 ? -41.16462 13.08775 -5.37040  1.000 34.51702 ? 148  LYS A CE  1 
ATOM   1206 N  NZ  . LYS A 1 148 ? -42.20910 13.86828 -6.09238  1.000 35.99771 ? 148  LYS A NZ  1 
ATOM   1207 N  N   . ASP A 1 149 ? -38.63035 15.82109 -9.13349  1.000 15.20554 ? 149  ASP A N   1 
ATOM   1208 C  CA  . ASP A 1 149 ? -38.77894 15.27089 -10.47398 1.000 19.75441 ? 149  ASP A CA  1 
ATOM   1209 C  C   . ASP A 1 149 ? -38.09269 16.10748 -11.54976 1.000 20.41651 ? 149  ASP A C   1 
ATOM   1210 O  O   . ASP A 1 149 ? -37.98811 15.65045 -12.69181 1.000 21.36956 ? 149  ASP A O   1 
ATOM   1211 C  CB  . ASP A 1 149 ? -40.26691 15.11462 -10.82113 1.000 19.14444 ? 149  ASP A CB  1 
ATOM   1212 C  CG  . ASP A 1 149 ? -40.97897 14.09997 -9.92667  1.000 21.54257 ? 149  ASP A CG  1 
ATOM   1213 O  OD1 . ASP A 1 149 ? -40.35921 13.08385 -9.56090  1.000 24.21625 ? 149  ASP A OD1 1 
ATOM   1214 O  OD2 . ASP A 1 149 ? -42.15898 14.32471 -9.59624  1.000 30.05890 ? 149  ASP A OD2 1 
ATOM   1215 N  N   . ASP A 1 150 ? -37.61506 17.30794 -11.21959 1.000 16.01398 ? 150  ASP A N   1 
ATOM   1216 C  CA  . ASP A 1 150 ? -37.02802 18.21132 -12.20186 1.000 17.30899 ? 150  ASP A CA  1 
ATOM   1217 C  C   . ASP A 1 150 ? -35.53984 18.45213 -12.00578 1.000 13.99059 ? 150  ASP A C   1 
ATOM   1218 O  O   . ASP A 1 150 ? -34.82923 18.66653 -12.98795 1.000 14.75840 ? 150  ASP A O   1 
ATOM   1219 C  CB  . ASP A 1 150 ? -37.73324 19.57301 -12.16780 1.000 15.34172 ? 150  ASP A CB  1 
ATOM   1220 C  CG  . ASP A 1 150 ? -39.23514 19.45407 -12.30532 1.000 28.90116 ? 150  ASP A CG  1 
ATOM   1221 O  OD1 . ASP A 1 150 ? -39.67784 18.77069 -13.24913 1.000 21.45608 ? 150  ASP A OD1 1 
ATOM   1222 O  OD2 . ASP A 1 150 ? -39.95477 20.04657 -11.46768 1.000 28.51473 ? 150  ASP A OD2 1 
ATOM   1223 N  N   . ILE A 1 151 ? -35.05844 18.44478 -10.76913 1.000 11.79430 ? 151  ILE A N   1 
ATOM   1224 C  CA  . ILE A 1 151 ? -33.69656 18.86173 -10.45597 1.000 12.89507 ? 151  ILE A CA  1 
ATOM   1225 C  C   . ILE A 1 151 ? -32.89007 17.62827 -10.07824 1.000 14.20025 ? 151  ILE A C   1 
ATOM   1226 O  O   . ILE A 1 151 ? -33.16981 16.97245 -9.06607  1.000 12.43482 ? 151  ILE A O   1 
ATOM   1227 C  CB  . ILE A 1 151 ? -33.67017 19.90542 -9.33196  1.000 14.17795 ? 151  ILE A CB  1 
ATOM   1228 C  CG1 . ILE A 1 151 ? -34.46541 21.14336 -9.75599  1.000 12.47938 ? 151  ILE A CG1 1 
ATOM   1229 C  CG2 . ILE A 1 151 ? -32.22088 20.27372 -9.00418  1.000 13.29366 ? 151  ILE A CG2 1 
ATOM   1230 C  CD1 . ILE A 1 151 ? -34.31336 22.34256 -8.82384  1.000 11.01692 ? 151  ILE A CD1 1 
ATOM   1231 N  N   . LYS A 1 152 ? -31.88673 17.31387 -10.88595 1.000 14.06086 ? 152  LYS A N   1 
ATOM   1232 C  CA  . LYS A 1 152 ? -31.12635 16.09130 -10.67091 1.000 15.15625 ? 152  LYS A CA  1 
ATOM   1233 C  C   . LYS A 1 152 ? -29.97503 16.25935 -9.68264  1.000 15.32331 ? 152  LYS A C   1 
ATOM   1234 O  O   . LYS A 1 152 ? -29.66681 15.31217 -8.95195  1.000 14.77945 ? 152  LYS A O   1 
ATOM   1235 C  CB  . LYS A 1 152 ? -30.59511 15.57995 -12.00863 1.000 16.80284 ? 152  LYS A CB  1 
ATOM   1236 C  CG  . LYS A 1 152 ? -29.70244 14.35913 -11.93056 1.000 22.81750 ? 152  LYS A CG  1 
ATOM   1237 C  CD  . LYS A 1 152 ? -29.30411 13.91903 -13.33757 1.000 28.47519 ? 152  LYS A CD  1 
ATOM   1238 C  CE  . LYS A 1 152 ? -29.38357 12.40727 -13.48432 1.000 39.08937 ? 152  LYS A CE  1 
ATOM   1239 N  NZ  . LYS A 1 152 ? -28.07053 11.78628 -13.81417 1.000 47.16370 ? 152  LYS A NZ  1 
ATOM   1240 N  N   . TYR A 1 153 ? -29.33107 17.42790 -9.63599  1.000 13.31397 ? 153  TYR A N   1 
ATOM   1241 C  CA  . TYR A 1 153 ? -28.12172 17.63260 -8.84228  1.000 12.05844 ? 153  TYR A CA  1 
ATOM   1242 C  C   . TYR A 1 153 ? -28.38112 18.66176 -7.75142  1.000 11.57102 ? 153  TYR A C   1 
ATOM   1243 O  O   . TYR A 1 153 ? -28.92259 19.73598 -8.02647  1.000 12.42493 ? 153  TYR A O   1 
ATOM   1244 C  CB  . TYR A 1 153 ? -26.96512 18.09507 -9.73155  1.000 10.68704 ? 153  TYR A CB  1 
ATOM   1245 C  CG  . TYR A 1 153 ? -26.65527 17.13092 -10.84909 1.000 14.76634 ? 153  TYR A CG  1 
ATOM   1246 C  CD1 . TYR A 1 153 ? -26.02046 15.92766 -10.58867 1.000 12.19534 ? 153  TYR A CD1 1 
ATOM   1247 C  CD2 . TYR A 1 153 ? -27.02171 17.40609 -12.15482 1.000 16.68909 ? 153  TYR A CD2 1 
ATOM   1248 C  CE1 . TYR A 1 153 ? -25.73129 15.02991 -11.59754 1.000 18.90999 ? 153  TYR A CE1 1 
ATOM   1249 C  CE2 . TYR A 1 153 ? -26.74228 16.50078 -13.18397 1.000 22.05536 ? 153  TYR A CE2 1 
ATOM   1250 C  CZ  . TYR A 1 153 ? -26.09278 15.31551 -12.89118 1.000 21.32573 ? 153  TYR A CZ  1 
ATOM   1251 O  OH  . TYR A 1 153 ? -25.80888 14.40592 -13.88678 1.000 22.66351 ? 153  TYR A OH  1 
ATOM   1252 N  N   . TRP A 1 154 ? -27.96008 18.35491 -6.52472  1.000 11.87484 ? 154  TRP A N   1 
ATOM   1253 C  CA  . TRP A 1 154 ? -28.27989 19.18744 -5.37030  1.000 11.57757 ? 154  TRP A CA  1 
ATOM   1254 C  C   . TRP A 1 154 ? -27.01923 19.52096 -4.58208  1.000 13.69259 ? 154  TRP A C   1 
ATOM   1255 O  O   . TRP A 1 154 ? -26.30019 18.61530 -4.14396  1.000 10.57827 ? 154  TRP A O   1 
ATOM   1256 C  CB  . TRP A 1 154 ? -29.29127 18.47897 -4.46933  1.000 13.53658 ? 154  TRP A CB  1 
ATOM   1257 C  CG  . TRP A 1 154 ? -30.62446 18.33451 -5.11370  1.000 11.57748 ? 154  TRP A CG  1 
ATOM   1258 C  CD1 . TRP A 1 154 ? -30.97106 17.44551 -6.08707  1.000 12.20965 ? 154  TRP A CD1 1 
ATOM   1259 C  CD2 . TRP A 1 154 ? -31.79631 19.11113 -4.83859  1.000 11.44227 ? 154  TRP A CD2 1 
ATOM   1260 N  NE1 . TRP A 1 154 ? -32.29373 17.61432 -6.43535  1.000 11.97340 ? 154  TRP A NE1 1 
ATOM   1261 C  CE2 . TRP A 1 154 ? -32.82265 18.63171 -5.68309  1.000 13.15221 ? 154  TRP A CE2 1 
ATOM   1262 C  CE3 . TRP A 1 154 ? -32.08010 20.15956 -3.95565  1.000 9.59364  ? 154  TRP A CE3 1 
ATOM   1263 C  CZ2 . TRP A 1 154 ? -34.11042 19.16904 -5.67770  1.000 12.73148 ? 154  TRP A CZ2 1 
ATOM   1264 C  CZ3 . TRP A 1 154 ? -33.36049 20.70551 -3.95956  1.000 11.58456 ? 154  TRP A CZ3 1 
ATOM   1265 C  CH2 . TRP A 1 154 ? -34.36334 20.19825 -4.81130  1.000 12.52313 ? 154  TRP A CH2 1 
ATOM   1266 N  N   . ASP A 1 155 ? -26.75257 20.81751 -4.40189  1.000 13.64119 ? 155  ASP A N   1 
ATOM   1267 C  CA  . ASP A 1 155 ? -25.79097 21.28199 -3.39956  1.000 10.90290 ? 155  ASP A CA  1 
ATOM   1268 C  C   . ASP A 1 155 ? -26.51392 21.22370 -2.05792  1.000 11.41906 ? 155  ASP A C   1 
ATOM   1269 O  O   . ASP A 1 155 ? -27.17634 22.17691 -1.64652  1.000 11.78440 ? 155  ASP A O   1 
ATOM   1270 C  CB  . ASP A 1 155 ? -25.30643 22.69847 -3.69857  1.000 10.86553 ? 155  ASP A CB  1 
ATOM   1271 C  CG  . ASP A 1 155 ? -24.36688 22.77108 -4.88572  1.000 11.51848 ? 155  ASP A CG  1 
ATOM   1272 O  OD1 . ASP A 1 155 ? -23.83049 21.72072 -5.30820  1.000 13.10528 ? 155  ASP A OD1 1 
ATOM   1273 O  OD2 . ASP A 1 155 ? -24.16151 23.89399 -5.39055  1.000 13.60389 ? 155  ASP A OD2 1 
ATOM   1274 N  N   . VAL A 1 156 ? -26.40982 20.08471 -1.36832  1.000 12.57340 ? 156  VAL A N   1 
ATOM   1275 C  CA  . VAL A 1 156 ? -27.17102 19.92175 -0.13003  1.000 14.18720 ? 156  VAL A CA  1 
ATOM   1276 C  C   . VAL A 1 156 ? -26.63168 20.84895 0.95144   1.000 14.39638 ? 156  VAL A C   1 
ATOM   1277 O  O   . VAL A 1 156 ? -27.39982 21.50512 1.66582   1.000 13.39332 ? 156  VAL A O   1 
ATOM   1278 C  CB  . VAL A 1 156 ? -27.16652 18.44713 0.31718   1.000 15.44781 ? 156  VAL A CB  1 
ATOM   1279 C  CG1 . VAL A 1 156 ? -27.69893 18.30379 1.73859   1.000 13.65071 ? 156  VAL A CG1 1 
ATOM   1280 C  CG2 . VAL A 1 156 ? -28.00466 17.60919 -0.63551  1.000 13.11409 ? 156  VAL A CG2 1 
ATOM   1281 N  N   . VAL A 1 157 ? -25.30577 20.93008 1.08613   1.000 15.47698 ? 157  VAL A N   1 
ATOM   1282 C  CA  . VAL A 1 157 ? -24.67441 21.88936 1.98026   1.000 13.70670 ? 157  VAL A CA  1 
ATOM   1283 C  C   . VAL A 1 157 ? -23.57595 22.60782 1.21411   1.000 14.75048 ? 157  VAL A C   1 
ATOM   1284 O  O   . VAL A 1 157 ? -22.98667 22.07004 0.27145   1.000 14.76775 ? 157  VAL A O   1 
ATOM   1285 C  CB  . VAL A 1 157 ? -24.10091 21.23975 3.26153   1.000 10.50066 ? 157  VAL A CB  1 
ATOM   1286 C  CG1 . VAL A 1 157 ? -25.17161 20.44841 3.98538   1.000 13.20543 ? 157  VAL A CG1 1 
ATOM   1287 C  CG2 . VAL A 1 157 ? -22.85426 20.36493 2.93361   1.000 12.38399 ? 157  VAL A CG2 1 
ATOM   1288 N  N   . ASN A 1 158 ? -23.31353 23.83973 1.62530   1.000 14.77123 ? 158  ASN A N   1 
ATOM   1289 C  CA  . ASN A 1 158 ? -22.34473 24.70465 0.97530   1.000 13.24818 ? 158  ASN A CA  1 
ATOM   1290 C  C   . ASN A 1 158 ? -21.40600 25.25355 2.04227   1.000 14.64975 ? 158  ASN A C   1 
ATOM   1291 O  O   . ASN A 1 158 ? -21.86147 25.79940 3.05035   1.000 15.33160 ? 158  ASN A O   1 
ATOM   1292 C  CB  . ASN A 1 158 ? -23.06922 25.83746 0.22493   1.000 13.09244 ? 158  ASN A CB  1 
ATOM   1293 C  CG  . ASN A 1 158 ? -22.14904 26.63104 -0.70381  1.000 15.49928 ? 158  ASN A CG  1 
ATOM   1294 O  OD1 . ASN A 1 158 ? -21.33314 26.07311 -1.43016  1.000 12.15648 ? 158  ASN A OD1 1 
ATOM   1295 N  ND2 . ASN A 1 158 ? -22.31081 27.93847 -0.69770  1.000 13.69608 ? 158  ASN A ND2 1 
ATOM   1296 N  N   . GLU A 1 159 ? -20.10316 25.07066 1.83635   1.000 16.86327 ? 159  GLU A N   1 
ATOM   1297 C  CA  . GLU A 1 159 ? -19.06962 25.76798 2.60247   1.000 15.54701 ? 159  GLU A CA  1 
ATOM   1298 C  C   . GLU A 1 159 ? -19.09852 25.40718 4.08796   1.000 12.54757 ? 159  GLU A C   1 
ATOM   1299 O  O   . GLU A 1 159 ? -18.95013 26.26696 4.95504   1.000 16.91119 ? 159  GLU A O   1 
ATOM   1300 C  CB  . GLU A 1 159 ? -19.17782 27.28250 2.40173   1.000 13.17783 ? 159  GLU A CB  1 
ATOM   1301 C  CG  . GLU A 1 159 ? -18.80277 27.71540 0.98416   1.000 15.04723 ? 159  GLU A CG  1 
ATOM   1302 C  CD  . GLU A 1 159 ? -18.98373 29.20627 0.72893   1.000 20.08361 ? 159  GLU A CD  1 
ATOM   1303 O  OE1 . GLU A 1 159 ? -19.11246 29.98076 1.70221   1.000 16.04910 ? 159  GLU A OE1 1 
ATOM   1304 O  OE2 . GLU A 1 159 ? -18.99224 29.60629 -0.45892  1.000 17.26134 ? 159  GLU A OE2 1 
ATOM   1305 N  N   . VAL A 1 160 ? -19.25834 24.12224 4.39898   1.000 9.55968  ? 160  VAL A N   1 
ATOM   1306 C  CA  . VAL A 1 160 ? -19.34982 23.73932 5.80853   1.000 14.16354 ? 160  VAL A CA  1 
ATOM   1307 C  C   . VAL A 1 160 ? -17.99571 23.45157 6.44773   1.000 21.34466 ? 160  VAL A C   1 
ATOM   1308 O  O   . VAL A 1 160 ? -17.93294 23.22127 7.66886   1.000 20.03540 ? 160  VAL A O   1 
ATOM   1309 C  CB  . VAL A 1 160 ? -20.27841 22.52592 5.98656   1.000 12.50388 ? 160  VAL A CB  1 
ATOM   1310 C  CG1 . VAL A 1 160 ? -21.64635 22.86938 5.44639   1.000 9.85815  ? 160  VAL A CG1 1 
ATOM   1311 C  CG2 . VAL A 1 160 ? -19.69207 21.28435 5.30148   1.000 12.50121 ? 160  VAL A CG2 1 
ATOM   1312 N  N   . VAL A 1 161 ? -16.91223 23.46165 5.67569   1.000 16.79214 ? 161  VAL A N   1 
ATOM   1313 C  CA  . VAL A 1 161 ? -15.56962 23.26706 6.21063   1.000 18.39400 ? 161  VAL A CA  1 
ATOM   1314 C  C   . VAL A 1 161 ? -14.86902 24.61312 6.19819   1.000 20.21551 ? 161  VAL A C   1 
ATOM   1315 O  O   . VAL A 1 161 ? -14.93194 25.34094 5.20053   1.000 18.66051 ? 161  VAL A O   1 
ATOM   1316 C  CB  . VAL A 1 161 ? -14.78567 22.21419 5.41167   1.000 15.97568 ? 161  VAL A CB  1 
ATOM   1317 C  CG1 . VAL A 1 161 ? -13.32396 22.13860 5.89657   1.000 19.93791 ? 161  VAL A CG1 1 
ATOM   1318 C  CG2 . VAL A 1 161 ? -15.45719 20.87002 5.53965   1.000 18.20654 ? 161  VAL A CG2 1 
ATOM   1319 N  N   . GLY A 1 162 ? -14.23348 24.96582 7.32268   1.000 18.27010 ? 162  GLY A N   1 
ATOM   1320 C  CA  . GLY A 1 162 ? -13.52245 26.21821 7.39024   1.000 18.33068 ? 162  GLY A CA  1 
ATOM   1321 C  C   . GLY A 1 162 ? -12.18555 26.16997 6.65910   1.000 17.89990 ? 162  GLY A C   1 
ATOM   1322 O  O   . GLY A 1 162 ? -11.59962 25.11630 6.41166   1.000 19.16415 ? 162  GLY A O   1 
ATOM   1323 N  N   . ASP A 1 163 ? -11.70658 27.35338 6.29509   1.000 17.01363 ? 163  ASP A N   1 
ATOM   1324 C  CA  . ASP A 1 163 ? -10.39977 27.45602 5.65913   1.000 15.42883 ? 163  ASP A CA  1 
ATOM   1325 C  C   . ASP A 1 163 ? -9.26164  27.06620 6.60273   1.000 24.14242 ? 163  ASP A C   1 
ATOM   1326 O  O   . ASP A 1 163 ? -8.17747  26.70422 6.12768   1.000 22.91595 ? 163  ASP A O   1 
ATOM   1327 C  CB  . ASP A 1 163 ? -10.21530 28.87110 5.12622   1.000 15.59090 ? 163  ASP A CB  1 
ATOM   1328 C  CG  . ASP A 1 163 ? -11.11626 29.15468 3.93420   1.000 20.28727 ? 163  ASP A CG  1 
ATOM   1329 O  OD1 . ASP A 1 163 ? -11.16188 28.30976 3.01341   1.000 19.29116 ? 163  ASP A OD1 1 
ATOM   1330 O  OD2 . ASP A 1 163 ? -11.78603 30.20349 3.91989   1.000 18.73123 ? 163  ASP A OD2 1 
ATOM   1331 N  N   . ASP A 1 164 ? -9.48911  27.10284 7.92049   1.000 22.83764 ? 164  ASP A N   1 
ATOM   1332 C  CA  . ASP A 1 164 ? -8.52029  26.61180 8.89576   1.000 21.63533 ? 164  ASP A CA  1 
ATOM   1333 C  C   . ASP A 1 164 ? -8.53919  25.09082 9.05279   1.000 25.69685 ? 164  ASP A C   1 
ATOM   1334 O  O   . ASP A 1 164 ? -7.87551  24.56919 9.95278   1.000 27.32620 ? 164  ASP A O   1 
ATOM   1335 C  CB  . ASP A 1 164 ? -8.75994  27.26563 10.26062  1.000 23.78907 ? 164  ASP A CB  1 
ATOM   1336 C  CG  . ASP A 1 164 ? -10.14389 26.94856 10.83785  1.000 27.33011 ? 164  ASP A CG  1 
ATOM   1337 O  OD1 . ASP A 1 164 ? -10.90832 26.17891 10.22157  1.000 26.48062 ? 164  ASP A OD1 1 
ATOM   1338 O  OD2 . ASP A 1 164 ? -10.46819 27.47079 11.92147  1.000 26.99015 ? 164  ASP A OD2 1 
ATOM   1339 N  N   . GLY A 1 165 ? -9.29794  24.36513 8.23705   1.000 18.79145 ? 165  GLY A N   1 
ATOM   1340 C  CA  . GLY A 1 165 ? -9.32830  22.91942 8.35017   1.000 20.72739 ? 165  GLY A CA  1 
ATOM   1341 C  C   . GLY A 1 165 ? -10.21457 22.37678 9.44923   1.000 20.83185 ? 165  GLY A C   1 
ATOM   1342 O  O   . GLY A 1 165 ? -10.25659 21.15298 9.64639   1.000 24.71030 ? 165  GLY A O   1 
ATOM   1343 N  N   . LYS A 1 166 ? -10.90895 23.23474 10.18126  1.000 20.72116 ? 166  LYS A N   1 
ATOM   1344 C  CA  . LYS A 1 166 ? -11.94662 22.80195 11.10062  1.000 18.98011 ? 166  LYS A CA  1 
ATOM   1345 C  C   . LYS A 1 166 ? -13.30734 22.99904 10.43854  1.000 21.33449 ? 166  LYS A C   1 
ATOM   1346 O  O   . LYS A 1 166 ? -13.45046 23.78064 9.49860   1.000 20.13420 ? 166  LYS A O   1 
ATOM   1347 C  CB  . LYS A 1 166 ? -11.87974 23.60147 12.40238  1.000 22.38969 ? 166  LYS A CB  1 
ATOM   1348 C  CG  . LYS A 1 166 ? -10.59198 23.40869 13.20426  1.000 30.68225 ? 166  LYS A CG  1 
ATOM   1349 C  CD  . LYS A 1 166 ? -10.44317 24.54455 14.21595  1.000 42.39336 ? 166  LYS A CD  1 
ATOM   1350 C  CE  . LYS A 1 166 ? -9.06164  24.55695 14.85929  1.000 49.26795 ? 166  LYS A CE  1 
ATOM   1351 N  NZ  . LYS A 1 166 ? -8.37422  23.24265 14.66253  1.000 48.39146 ? 166  LYS A NZ  1 
ATOM   1352 N  N   . LEU A 1 167 ? -14.31520 22.28403 10.93198  1.000 21.90396 ? 167  LEU A N   1 
ATOM   1353 C  CA  . LEU A 1 167 ? -15.67077 22.58547 10.48992  1.000 22.85143 ? 167  LEU A CA  1 
ATOM   1354 C  C   . LEU A 1 167 ? -15.94352 24.06716 10.70166  1.000 19.20704 ? 167  LEU A C   1 
ATOM   1355 O  O   . LEU A 1 167 ? -15.48460 24.66322 11.68288  1.000 24.23007 ? 167  LEU A O   1 
ATOM   1356 C  CB  . LEU A 1 167 ? -16.69247 21.72636 11.23984  1.000 19.78373 ? 167  LEU A CB  1 
ATOM   1357 C  CG  . LEU A 1 167 ? -16.66626 20.25388 10.84594  1.000 24.23191 ? 167  LEU A CG  1 
ATOM   1358 C  CD1 . LEU A 1 167 ? -17.56795 19.41275 11.71541  1.000 32.86396 ? 167  LEU A CD1 1 
ATOM   1359 C  CD2 . LEU A 1 167 ? -17.08217 20.11560 9.40272   1.000 30.49652 ? 167  LEU A CD2 1 
ATOM   1360 N  N   . ARG A 1 168 ? -16.64711 24.67825 9.75172   1.000 15.76000 ? 168  ARG A N   1 
ATOM   1361 C  CA  . ARG A 1 168 ? -16.94982 26.09850 9.86696   1.000 17.09675 ? 168  ARG A CA  1 
ATOM   1362 C  C   . ARG A 1 168 ? -17.85504 26.34515 11.06758  1.000 22.70682 ? 168  ARG A C   1 
ATOM   1363 O  O   . ARG A 1 168 ? -18.89312 25.68906 11.22111  1.000 21.23836 ? 168  ARG A O   1 
ATOM   1364 C  CB  . ARG A 1 168 ? -17.61968 26.61106 8.58607   1.000 16.21675 ? 168  ARG A CB  1 
ATOM   1365 C  CG  . ARG A 1 168 ? -17.94071 28.09908 8.65544   1.000 18.04523 ? 168  ARG A CG  1 
ATOM   1366 C  CD  . ARG A 1 168 ? -18.63206 28.61218 7.39131   1.000 15.10117 ? 168  ARG A CD  1 
ATOM   1367 N  NE  . ARG A 1 168 ? -17.79505 28.45332 6.20347   1.000 18.40416 ? 168  ARG A NE  1 
ATOM   1368 C  CZ  . ARG A 1 168 ? -16.93031 29.36791 5.77557   1.000 19.26476 ? 168  ARG A CZ  1 
ATOM   1369 N  NH1 . ARG A 1 168 ? -16.77359 30.49590 6.45677   1.000 17.11996 ? 168  ARG A NH1 1 
ATOM   1370 N  NH2 . ARG A 1 168 ? -16.21017 29.14880 4.68202   1.000 17.34634 ? 168  ARG A NH2 1 
ATOM   1371 N  N   . ASN A 1 169 ? -17.46257 27.29053 11.92208  1.000 22.72541 ? 169  ASN A N   1 
ATOM   1372 C  CA  . ASN A 1 169 ? -18.19108 27.53668 13.16981  1.000 23.67014 ? 169  ASN A CA  1 
ATOM   1373 C  C   . ASN A 1 169 ? -19.34948 28.50778 12.96364  1.000 23.24177 ? 169  ASN A C   1 
ATOM   1374 O  O   . ASN A 1 169 ? -19.48761 29.50650 13.66569  1.000 20.29025 ? 169  ASN A O   1 
ATOM   1375 C  CB  . ASN A 1 169 ? -17.24153 28.04620 14.24946  1.000 22.47282 ? 169  ASN A CB  1 
ATOM   1376 C  CG  . ASN A 1 169 ? -17.80150 27.85255 15.65288  1.000 26.77773 ? 169  ASN A CG  1 
ATOM   1377 O  OD1 . ASN A 1 169 ? -18.43664 26.83781 15.94801  1.000 26.93906 ? 169  ASN A OD1 1 
ATOM   1378 N  ND2 . ASN A 1 169 ? -17.57883 28.83107 16.52051  1.000 32.11645 ? 169  ASN A ND2 1 
ATOM   1379 N  N   . SER A 1 170 ? -20.19722 28.20921 11.98320  1.000 19.38301 ? 170  SER A N   1 
ATOM   1380 C  CA  . SER A 1 170 ? -21.39770 28.98296 11.73465  1.000 19.66316 ? 170  SER A CA  1 
ATOM   1381 C  C   . SER A 1 170 ? -22.44549 28.69515 12.81394  1.000 20.24949 ? 170  SER A C   1 
ATOM   1382 O  O   . SER A 1 170 ? -22.33205 27.72214 13.56508  1.000 18.61556 ? 170  SER A O   1 
ATOM   1383 C  CB  . SER A 1 170 ? -21.97629 28.61027 10.37424  1.000 16.16940 ? 170  SER A CB  1 
ATOM   1384 O  OG  . SER A 1 170 ? -22.36032 27.24572 10.39062  1.000 17.00253 ? 170  SER A OG  1 
ATOM   1385 N  N   . PRO A 1 171 ? -23.51619 29.49640 12.87724  1.000 19.98973 ? 171  PRO A N   1 
ATOM   1386 C  CA  . PRO A 1 171 ? -24.61960 29.15759 13.79344  1.000 22.84578 ? 171  PRO A CA  1 
ATOM   1387 C  C   . PRO A 1 171 ? -25.15198 27.74477 13.61438  1.000 22.44778 ? 171  PRO A C   1 
ATOM   1388 O  O   . PRO A 1 171 ? -25.53751 27.11017 14.60560  1.000 24.51823 ? 171  PRO A O   1 
ATOM   1389 C  CB  . PRO A 1 171 ? -25.68054 30.21431 13.45350  1.000 24.84008 ? 171  PRO A CB  1 
ATOM   1390 C  CG  . PRO A 1 171 ? -24.89048 31.38352 12.95277  1.000 20.08116 ? 171  PRO A CG  1 
ATOM   1391 C  CD  . PRO A 1 171 ? -23.74474 30.78507 12.19586  1.000 21.33858 ? 171  PRO A CD  1 
ATOM   1392 N  N   . TRP A 1 172 ? -25.19971 27.23779 12.37450  1.000 19.55478 ? 172  TRP A N   1 
ATOM   1393 C  CA  . TRP A 1 172 ? -25.55387 25.83858 12.15383  1.000 17.51454 ? 172  TRP A CA  1 
ATOM   1394 C  C   . TRP A 1 172 ? -24.71979 24.92592 13.04136  1.000 19.61873 ? 172  TRP A C   1 
ATOM   1395 O  O   . TRP A 1 172 ? -25.25083 24.05871 13.74382  1.000 17.86339 ? 172  TRP A O   1 
ATOM   1396 C  CB  . TRP A 1 172 ? -25.34911 25.45997 10.67945  1.000 16.97690 ? 172  TRP A CB  1 
ATOM   1397 C  CG  . TRP A 1 172 ? -26.34572 26.07204 9.73501   1.000 20.28345 ? 172  TRP A CG  1 
ATOM   1398 C  CD1 . TRP A 1 172 ? -26.10367 27.02473 8.78258   1.000 19.12392 ? 172  TRP A CD1 1 
ATOM   1399 C  CD2 . TRP A 1 172 ? -27.73975 25.75797 9.64278   1.000 20.74627 ? 172  TRP A CD2 1 
ATOM   1400 N  NE1 . TRP A 1 172 ? -27.26581 27.32755 8.10941   1.000 17.11040 ? 172  TRP A NE1 1 
ATOM   1401 C  CE2 . TRP A 1 172 ? -28.28316 26.56228 8.61907   1.000 18.21128 ? 172  TRP A CE2 1 
ATOM   1402 C  CE3 . TRP A 1 172 ? -28.58355 24.87660 10.33209  1.000 15.12441 ? 172  TRP A CE3 1 
ATOM   1403 C  CZ2 . TRP A 1 172 ? -29.63377 26.51370 8.26852   1.000 19.42342 ? 172  TRP A CZ2 1 
ATOM   1404 C  CZ3 . TRP A 1 172 ? -29.91945 24.82544 9.97904   1.000 18.44435 ? 172  TRP A CZ3 1 
ATOM   1405 C  CH2 . TRP A 1 172 ? -30.43332 25.63761 8.95499   1.000 20.16057 ? 172  TRP A CH2 1 
ATOM   1406 N  N   . TYR A 1 173 ? -23.39892 25.10503 13.01309  1.000 19.94437 ? 173  TYR A N   1 
ATOM   1407 C  CA  . TYR A 1 173 ? -22.52943 24.19638 13.74892  1.000 22.15565 ? 173  TYR A CA  1 
ATOM   1408 C  C   . TYR A 1 173 ? -22.55308 24.49903 15.24286  1.000 19.98725 ? 173  TYR A C   1 
ATOM   1409 O  O   . TYR A 1 173 ? -22.60310 23.57505 16.05863  1.000 22.85300 ? 173  TYR A O   1 
ATOM   1410 C  CB  . TYR A 1 173 ? -21.10319 24.27062 13.19573  1.000 20.52282 ? 173  TYR A CB  1 
ATOM   1411 C  CG  . TYR A 1 173 ? -20.14604 23.27709 13.81601  1.000 24.12968 ? 173  TYR A CG  1 
ATOM   1412 C  CD1 . TYR A 1 173 ? -20.28348 21.91202 13.59547  1.000 22.44214 ? 173  TYR A CD1 1 
ATOM   1413 C  CD2 . TYR A 1 173 ? -19.09430 23.70929 14.61909  1.000 25.38426 ? 173  TYR A CD2 1 
ATOM   1414 C  CE1 . TYR A 1 173 ? -19.40487 21.00521 14.16779  1.000 26.72712 ? 173  TYR A CE1 1 
ATOM   1415 C  CE2 . TYR A 1 173 ? -18.21310 22.81194 15.19049  1.000 25.08968 ? 173  TYR A CE2 1 
ATOM   1416 C  CZ  . TYR A 1 173 ? -18.36846 21.46854 14.96252  1.000 28.85523 ? 173  TYR A CZ  1 
ATOM   1417 O  OH  . TYR A 1 173 ? -17.48308 20.58914 15.53891  1.000 33.47100 ? 173  TYR A OH  1 
ATOM   1418 N  N   . GLN A 1 174 ? -22.54221 25.78277 15.61480  1.000 21.67449 ? 174  GLN A N   1 
ATOM   1419 C  CA  . GLN A 1 174 ? -22.61588 26.14469 17.02781  1.000 23.64886 ? 174  GLN A CA  1 
ATOM   1420 C  C   . GLN A 1 174 ? -23.83879 25.53450 17.69251  1.000 29.08948 ? 174  GLN A C   1 
ATOM   1421 O  O   . GLN A 1 174 ? -23.76077 25.03495 18.82101  1.000 26.36491 ? 174  GLN A O   1 
ATOM   1422 C  CB  . GLN A 1 174 ? -22.66411 27.65852 17.18792  1.000 23.48559 ? 174  GLN A CB  1 
ATOM   1423 C  CG  . GLN A 1 174 ? -21.40159 28.38365 16.85559  1.000 25.29598 ? 174  GLN A CG  1 
ATOM   1424 C  CD  . GLN A 1 174 ? -21.61565 29.86854 16.93565  1.000 30.99176 ? 174  GLN A CD  1 
ATOM   1425 O  OE1 . GLN A 1 174 ? -21.97619 30.39072 17.98673  1.000 33.69812 ? 174  GLN A OE1 1 
ATOM   1426 N  NE2 . GLN A 1 174 ? -21.43067 30.56283 15.81154  1.000 31.92185 ? 174  GLN A NE2 1 
ATOM   1427 N  N   . ILE A 1 175 ? -24.97750 25.55619 17.00159  1.000 27.19189 ? 175  ILE A N   1 
ATOM   1428 C  CA  . ILE A 1 175 ? -26.23108 25.15420 17.62622  1.000 23.45863 ? 175  ILE A CA  1 
ATOM   1429 C  C   . ILE A 1 175 ? -26.42447 23.64813 17.54939  1.000 29.92575 ? 175  ILE A C   1 
ATOM   1430 O  O   . ILE A 1 175 ? -26.80870 23.01479 18.53613  1.000 27.10060 ? 175  ILE A O   1 
ATOM   1431 C  CB  . ILE A 1 175 ? -27.40140 25.91324 16.98218  1.000 18.20688 ? 175  ILE A CB  1 
ATOM   1432 C  CG1 . ILE A 1 175 ? -27.24683 27.40734 17.26146  1.000 21.10402 ? 175  ILE A CG1 1 
ATOM   1433 C  CG2 . ILE A 1 175 ? -28.71925 25.37361 17.48357  1.000 24.96351 ? 175  ILE A CG2 1 
ATOM   1434 C  CD1 . ILE A 1 175 ? -28.07014 28.30221 16.35167  1.000 22.44804 ? 175  ILE A CD1 1 
ATOM   1435 N  N   . ALA A 1 176 ? -26.16114 23.04067 16.39213  1.000 25.02371 ? 176  ALA A N   1 
ATOM   1436 C  CA  . ALA A 1 176 ? -26.50049 21.64089 16.19678  1.000 23.68190 ? 176  ALA A CA  1 
ATOM   1437 C  C   . ALA A 1 176 ? -25.29999 20.72629 16.06718  1.000 22.25893 ? 176  ALA A C   1 
ATOM   1438 O  O   . ALA A 1 176 ? -25.48587 19.50576 16.02564  1.000 28.50029 ? 176  ALA A O   1 
ATOM   1439 C  CB  . ALA A 1 176 ? -27.38922 21.47272 14.95265  1.000 25.60432 ? 176  ALA A CB  1 
ATOM   1440 N  N   . GLY A 1 177 ? -24.08024 21.26834 16.00161  1.000 28.47833 ? 177  GLY A N   1 
ATOM   1441 C  CA  . GLY A 1 177 ? -22.94072 20.39594 15.77633  1.000 24.76141 ? 177  GLY A CA  1 
ATOM   1442 C  C   . GLY A 1 177 ? -22.99632 19.78494 14.38562  1.000 26.77343 ? 177  GLY A C   1 
ATOM   1443 O  O   . GLY A 1 177 ? -23.69243 20.26835 13.48961  1.000 25.88470 ? 177  GLY A O   1 
ATOM   1444 N  N   . ILE A 1 178 ? -22.25903 18.68092 14.22381  1.000 25.27561 ? 178  ILE A N   1 
ATOM   1445 C  CA  . ILE A 1 178 ? -22.13000 18.03909 12.91931  1.000 23.67089 ? 178  ILE A CA  1 
ATOM   1446 C  C   . ILE A 1 178 ? -23.45443 17.47567 12.42179  1.000 24.98562 ? 178  ILE A C   1 
ATOM   1447 O  O   . ILE A 1 178 ? -23.60714 17.23939 11.21808  1.000 19.28952 ? 178  ILE A O   1 
ATOM   1448 C  CB  . ILE A 1 178 ? -21.04164 16.93795 12.95799  1.000 24.65853 ? 178  ILE A CB  1 
ATOM   1449 C  CG1 . ILE A 1 178 ? -20.61084 16.54496 11.54178  1.000 24.56455 ? 178  ILE A CG1 1 
ATOM   1450 C  CG2 . ILE A 1 178 ? -21.52096 15.70652 13.71148  1.000 27.66050 ? 178  ILE A CG2 1 
ATOM   1451 C  CD1 . ILE A 1 178 ? -19.48933 15.52772 11.48722  1.000 28.14873 ? 178  ILE A CD1 1 
ATOM   1452 N  N   . ASP A 1 179 ? -24.42954 17.26767 13.30883  1.000 22.34133 ? 179  ASP A N   1 
ATOM   1453 C  CA  . ASP A 1 179 ? -25.68610 16.65784 12.88940  1.000 23.72268 ? 179  ASP A CA  1 
ATOM   1454 C  C   . ASP A 1 179 ? -26.43901 17.47946 11.84473  1.000 17.69610 ? 179  ASP A C   1 
ATOM   1455 O  O   . ASP A 1 179 ? -27.27869 16.91423 11.13510  1.000 20.23419 ? 179  ASP A O   1 
ATOM   1456 C  CB  . ASP A 1 179 ? -26.59312 16.42370 14.09892  1.000 23.00928 ? 179  ASP A CB  1 
ATOM   1457 C  CG  . ASP A 1 179 ? -26.19533 15.19216 14.88917  1.000 32.37643 ? 179  ASP A CG  1 
ATOM   1458 O  OD1 . ASP A 1 179 ? -25.49974 14.31845 14.32723  1.000 28.47525 ? 179  ASP A OD1 1 
ATOM   1459 O  OD2 . ASP A 1 179 ? -26.58168 15.09599 16.07224  1.000 34.99812 ? 179  ASP A OD2 1 
ATOM   1460 N  N   . TYR A 1 180 ? -26.18588 18.78936 11.73062  1.000 15.14458 ? 180  TYR A N   1 
ATOM   1461 C  CA  . TYR A 1 180 ? -26.94847 19.54882 10.73587  1.000 18.13834 ? 180  TYR A CA  1 
ATOM   1462 C  C   . TYR A 1 180 ? -26.57605 19.11522 9.32751   1.000 17.18636 ? 180  TYR A C   1 
ATOM   1463 O  O   . TYR A 1 180 ? -27.43599 19.07957 8.43684   1.000 16.57242 ? 180  TYR A O   1 
ATOM   1464 C  CB  . TYR A 1 180 ? -26.77078 21.06501 10.92572  1.000 17.23159 ? 180  TYR A CB  1 
ATOM   1465 C  CG  . TYR A 1 180 ? -25.54062 21.71015 10.28621  1.000 17.28834 ? 180  TYR A CG  1 
ATOM   1466 C  CD1 . TYR A 1 180 ? -24.33646 21.80245 10.97803  1.000 19.84475 ? 180  TYR A CD1 1 
ATOM   1467 C  CD2 . TYR A 1 180 ? -25.59943 22.25525 9.01250   1.000 13.72007 ? 180  TYR A CD2 1 
ATOM   1468 C  CE1 . TYR A 1 180 ? -23.20800 22.40545 10.40087  1.000 16.22404 ? 180  TYR A CE1 1 
ATOM   1469 C  CE2 . TYR A 1 180 ? -24.48658 22.85989 8.42994   1.000 17.33728 ? 180  TYR A CE2 1 
ATOM   1470 C  CZ  . TYR A 1 180 ? -23.29343 22.92972 9.12848   1.000 16.46596 ? 180  TYR A CZ  1 
ATOM   1471 O  OH  . TYR A 1 180 ? -22.19374 23.53743 8.55899   1.000 13.72546 ? 180  TYR A OH  1 
ATOM   1472 N  N   . ILE A 1 181 ? -25.32121 18.71721 9.13234   1.000 17.56405 ? 181  ILE A N   1 
ATOM   1473 C  CA  . ILE A 1 181 ? -24.88259 18.18444 7.84787   1.000 15.53815 ? 181  ILE A CA  1 
ATOM   1474 C  C   . ILE A 1 181 ? -25.53088 16.83171 7.58620   1.000 19.85787 ? 181  ILE A C   1 
ATOM   1475 O  O   . ILE A 1 181 ? -26.06428 16.57633 6.49653   1.000 16.83246 ? 181  ILE A O   1 
ATOM   1476 C  CB  . ILE A 1 181 ? -23.34685 18.08568 7.82703   1.000 16.42772 ? 181  ILE A CB  1 
ATOM   1477 C  CG1 . ILE A 1 181 ? -22.72094 19.47689 8.01223   1.000 14.00606 ? 181  ILE A CG1 1 
ATOM   1478 C  CG2 . ILE A 1 181 ? -22.86232 17.42813 6.54105   1.000 12.94722 ? 181  ILE A CG2 1 
ATOM   1479 C  CD1 . ILE A 1 181 ? -21.23429 19.42672 8.37269   1.000 14.83230 ? 181  ILE A CD1 1 
ATOM   1480 N  N   . LYS A 1 182 ? -25.48942 15.94059 8.58451   1.000 17.00481 ? 182  LYS A N   1 
ATOM   1481 C  CA  . LYS A 1 182 ? -26.10045 14.62248 8.43614   1.000 16.10508 ? 182  LYS A CA  1 
ATOM   1482 C  C   . LYS A 1 182 ? -27.59155 14.73889 8.18145   1.000 16.90155 ? 182  LYS A C   1 
ATOM   1483 O  O   . LYS A 1 182 ? -28.13944 14.01947 7.34183   1.000 19.00422 ? 182  LYS A O   1 
ATOM   1484 C  CB  . LYS A 1 182 ? -25.86083 13.76727 9.68495   1.000 20.81883 ? 182  LYS A CB  1 
ATOM   1485 C  CG  . LYS A 1 182 ? -24.41756 13.63696 10.11169  1.000 22.26386 ? 182  LYS A CG  1 
ATOM   1486 C  CD  . LYS A 1 182 ? -24.28608 12.71632 11.33307  1.000 30.34621 ? 182  LYS A CD  1 
ATOM   1487 C  CE  . LYS A 1 182 ? -22.83258 12.65330 11.80668  1.000 37.46209 ? 182  LYS A CE  1 
ATOM   1488 N  NZ  . LYS A 1 182 ? -22.63075 11.74649 12.97598  1.000 39.87893 ? 182  LYS A NZ  1 
ATOM   1489 N  N   . VAL A 1 183 ? -28.26000 15.65496 8.88531   1.000 17.48318 ? 183  VAL A N   1 
ATOM   1490 C  CA  . VAL A 1 183 ? -29.70813 15.78768 8.74831   1.000 19.46648 ? 183  VAL A CA  1 
ATOM   1491 C  C   . VAL A 1 183 ? -30.06373 16.33010 7.36781   1.000 21.08997 ? 183  VAL A C   1 
ATOM   1492 O  O   . VAL A 1 183 ? -31.03690 15.88658 6.74044   1.000 18.95255 ? 183  VAL A O   1 
ATOM   1493 C  CB  . VAL A 1 183 ? -30.26627 16.66916 9.88355   1.000 18.54579 ? 183  VAL A CB  1 
ATOM   1494 C  CG1 . VAL A 1 183 ? -31.57980 17.30842 9.49241   1.000 17.75024 ? 183  VAL A CG1 1 
ATOM   1495 C  CG2 . VAL A 1 183 ? -30.43314 15.84890 11.14614  1.000 23.16424 ? 183  VAL A CG2 1 
ATOM   1496 N  N   . ALA A 1 184 ? -29.27217 17.27955 6.86501   1.000 14.03709 ? 184  ALA A N   1 
ATOM   1497 C  CA  . ALA A 1 184 ? -29.54606 17.84951 5.55304   1.000 15.62506 ? 184  ALA A CA  1 
ATOM   1498 C  C   . ALA A 1 184 ? -29.51744 16.77827 4.46790   1.000 12.10219 ? 184  ALA A C   1 
ATOM   1499 O  O   . ALA A 1 184 ? -30.44528 16.67657 3.66364   1.000 14.01492 ? 184  ALA A O   1 
ATOM   1500 C  CB  . ALA A 1 184 ? -28.54807 18.97122 5.24744   1.000 12.04695 ? 184  ALA A CB  1 
ATOM   1501 N  N   . PHE A 1 185 ? -28.46168 15.95711 4.43755   1.000 13.88188 ? 185  PHE A N   1 
ATOM   1502 C  CA  . PHE A 1 185 ? -28.36520 14.91407 3.42035   1.000 15.85580 ? 185  PHE A CA  1 
ATOM   1503 C  C   . PHE A 1 185 ? -29.43847 13.84337 3.60560   1.000 14.35735 ? 185  PHE A C   1 
ATOM   1504 O  O   . PHE A 1 185 ? -30.01795 13.36194 2.62162   1.000 15.75073 ? 185  PHE A O   1 
ATOM   1505 C  CB  . PHE A 1 185 ? -26.96695 14.28365 3.44439   1.000 16.49313 ? 185  PHE A CB  1 
ATOM   1506 C  CG  . PHE A 1 185 ? -25.90832 15.12639 2.77407   1.000 15.73773 ? 185  PHE A CG  1 
ATOM   1507 C  CD1 . PHE A 1 185 ? -25.73070 15.07684 1.39855   1.000 16.04248 ? 185  PHE A CD1 1 
ATOM   1508 C  CD2 . PHE A 1 185 ? -25.11010 15.98103 3.51856   1.000 14.77443 ? 185  PHE A CD2 1 
ATOM   1509 C  CE1 . PHE A 1 185 ? -24.75448 15.85639 0.77919   1.000 17.25253 ? 185  PHE A CE1 1 
ATOM   1510 C  CE2 . PHE A 1 185 ? -24.13406 16.76676 2.90570   1.000 17.45266 ? 185  PHE A CE2 1 
ATOM   1511 C  CZ  . PHE A 1 185 ? -23.96116 16.70181 1.53908   1.000 14.30785 ? 185  PHE A CZ  1 
ATOM   1512 N  N   . GLN A 1 186 ? -29.69761 13.43616 4.84993   1.000 16.54222 ? 186  GLN A N   1 
ATOM   1513 C  CA  . GLN A 1 186 ? -30.72326 12.42011 5.08959   1.000 19.45508 ? 186  GLN A CA  1 
ATOM   1514 C  C   . GLN A 1 186 ? -32.09531 12.92264 4.65589   1.000 15.43399 ? 186  GLN A C   1 
ATOM   1515 O  O   . GLN A 1 186 ? -32.88289 12.17989 4.05525   1.000 17.05539 ? 186  GLN A O   1 
ATOM   1516 C  CB  . GLN A 1 186 ? -30.73623 12.01800 6.57071   1.000 20.76301 ? 186  GLN A CB  1 
ATOM   1517 C  CG  . GLN A 1 186 ? -29.45044 11.32583 7.07747   1.000 18.52408 ? 186  GLN A CG  1 
ATOM   1518 C  CD  . GLN A 1 186 ? -29.28936 9.88377  6.59459   1.000 35.16900 ? 186  GLN A CD  1 
ATOM   1519 O  OE1 . GLN A 1 186 ? -30.02138 9.41304  5.71179   1.000 34.61631 ? 186  GLN A OE1 1 
ATOM   1520 N  NE2 . GLN A 1 186 ? -28.31401 9.17419  7.17273   1.000 33.84033 ? 186  GLN A NE2 1 
ATOM   1521 N  N   . ALA A 1 187 ? -32.38491 14.19540 4.91997   1.000 15.99310 ? 187  ALA A N   1 
ATOM   1522 C  CA  . ALA A 1 187 ? -33.67885 14.74615 4.53420   1.000 15.00718 ? 187  ALA A CA  1 
ATOM   1523 C  C   . ALA A 1 187 ? -33.80974 14.84379 3.02034   1.000 14.73482 ? 187  ALA A C   1 
ATOM   1524 O  O   . ALA A 1 187 ? -34.88289 14.56892 2.46891   1.000 14.99934 ? 187  ALA A O   1 
ATOM   1525 C  CB  . ALA A 1 187 ? -33.88007 16.11931 5.18135   1.000 15.62187 ? 187  ALA A CB  1 
ATOM   1526 N  N   . ALA A 1 188 ? -32.74272 15.25696 2.32686   1.000 12.31676 ? 188  ALA A N   1 
ATOM   1527 C  CA  . ALA A 1 188 ? -32.83220 15.36156 0.87270   1.000 14.39492 ? 188  ALA A CA  1 
ATOM   1528 C  C   . ALA A 1 188 ? -33.06851 13.99489 0.24333   1.000 15.34306 ? 188  ALA A C   1 
ATOM   1529 O  O   . ALA A 1 188 ? -33.89326 13.85495 -0.66720  1.000 18.13498 ? 188  ALA A O   1 
ATOM   1530 C  CB  . ALA A 1 188 ? -31.56299 16.00137 0.29614   1.000 13.88520 ? 188  ALA A CB  1 
ATOM   1531 N  N   . ARG A 1 189 ? -32.34140 12.97573 0.71026   1.000 14.34292 ? 189  ARG A N   1 
ATOM   1532 C  CA  . ARG A 1 189 ? -32.56180 11.61384 0.22921   1.000 15.57445 ? 189  ARG A CA  1 
ATOM   1533 C  C   . ARG A 1 189 ? -33.97709 11.12679 0.53514   1.000 16.77889 ? 189  ARG A C   1 
ATOM   1534 O  O   . ARG A 1 189 ? -34.61377 10.46682 -0.30038  1.000 16.49088 ? 189  ARG A O   1 
ATOM   1535 C  CB  . ARG A 1 189 ? -31.54034 10.67067 0.86568   1.000 15.52652 ? 189  ARG A CB  1 
ATOM   1536 C  CG  . ARG A 1 189 ? -31.71850 9.21557  0.45178   1.000 18.49182 ? 189  ARG A CG  1 
ATOM   1537 C  CD  . ARG A 1 189 ? -31.51477 9.03667  -1.04935  1.000 16.54628 ? 189  ARG A CD  1 
ATOM   1538 N  NE  . ARG A 1 189 ? -30.11024 9.18039  -1.42433  1.000 16.76205 ? 189  ARG A NE  1 
ATOM   1539 C  CZ  . ARG A 1 189 ? -29.68092 9.81002  -2.51927  1.000 20.72916 ? 189  ARG A CZ  1 
ATOM   1540 N  NH1 . ARG A 1 189 ? -30.54866 10.36239 -3.35154  1.000 20.92224 ? 189  ARG A NH1 1 
ATOM   1541 N  NH2 . ARG A 1 189 ? -28.38217 9.89087  -2.78249  1.000 17.48889 ? 189  ARG A NH2 1 
ATOM   1542 N  N   . LYS A 1 190 ? -34.47463 11.41845 1.73573   1.000 16.06645 ? 190  LYS A N   1 
ATOM   1543 C  CA  . LYS A 1 190 ? -35.76844 10.87974 2.16103   1.000 18.60129 ? 190  LYS A CA  1 
ATOM   1544 C  C   . LYS A 1 190 ? -36.90463 11.40707 1.29274   1.000 17.47791 ? 190  LYS A C   1 
ATOM   1545 O  O   . LYS A 1 190 ? -37.75527 10.63949 0.83015   1.000 21.72905 ? 190  LYS A O   1 
ATOM   1546 C  CB  . LYS A 1 190 ? -36.02359 11.22319 3.63012   1.000 20.40229 ? 190  LYS A CB  1 
ATOM   1547 C  CG  . LYS A 1 190 ? -37.45058 10.93409 4.10668   1.000 18.44866 ? 190  LYS A CG  1 
ATOM   1548 C  CD  . LYS A 1 190 ? -37.58821 11.20830 5.59616   1.000 24.40629 ? 190  LYS A CD  1 
ATOM   1549 C  CE  . LYS A 1 190 ? -38.96897 10.80384 6.13363   1.000 29.65761 ? 190  LYS A CE  1 
ATOM   1550 N  NZ  . LYS A 1 190 ? -39.08044 11.10139 7.59956   1.000 26.91740 ? 190  LYS A NZ  1 
ATOM   1551 N  N   . TYR A 1 191 ? -36.94577 12.72099 1.07418   1.000 20.07258 ? 191  TYR A N   1 
ATOM   1552 C  CA  . TYR A 1 191 ? -38.04050 13.32876 0.33046   1.000 17.28137 ? 191  TYR A CA  1 
ATOM   1553 C  C   . TYR A 1 191 ? -37.77031 13.40555 -1.15702  1.000 18.83485 ? 191  TYR A C   1 
ATOM   1554 O  O   . TYR A 1 191 ? -38.70372 13.67200 -1.92275  1.000 15.82823 ? 191  TYR A O   1 
ATOM   1555 C  CB  . TYR A 1 191 ? -38.34447 14.72726 0.88459   1.000 17.93065 ? 191  TYR A CB  1 
ATOM   1556 C  CG  . TYR A 1 191 ? -38.76747 14.65252 2.32235   1.000 19.60704 ? 191  TYR A CG  1 
ATOM   1557 C  CD1 . TYR A 1 191 ? -40.01253 14.14197 2.66611   1.000 21.36772 ? 191  TYR A CD1 1 
ATOM   1558 C  CD2 . TYR A 1 191 ? -37.90957 15.03534 3.34326   1.000 19.66341 ? 191  TYR A CD2 1 
ATOM   1559 C  CE1 . TYR A 1 191 ? -40.40311 14.03717 3.98313   1.000 20.43645 ? 191  TYR A CE1 1 
ATOM   1560 C  CE2 . TYR A 1 191 ? -38.29281 14.93686 4.67155   1.000 22.54866 ? 191  TYR A CE2 1 
ATOM   1561 C  CZ  . TYR A 1 191 ? -39.54485 14.42951 4.98183   1.000 23.49570 ? 191  TYR A CZ  1 
ATOM   1562 O  OH  . TYR A 1 191 ? -39.94701 14.33184 6.29578   1.000 29.35472 ? 191  TYR A OH  1 
ATOM   1563 N  N   . GLY A 1 192 ? -36.53229 13.15378 -1.58555  1.000 17.22012 ? 192  GLY A N   1 
ATOM   1564 C  CA  . GLY A 1 192 ? -36.20250 13.23211 -2.99343  1.000 15.42529 ? 192  GLY A CA  1 
ATOM   1565 C  C   . GLY A 1 192 ? -36.07164 11.89797 -3.69006  1.000 19.83239 ? 192  GLY A C   1 
ATOM   1566 O  O   . GLY A 1 192 ? -36.23024 11.82103 -4.91281  1.000 21.07626 ? 192  GLY A O   1 
ATOM   1567 N  N   . GLY A 1 193 ? -35.77529 10.83975 -2.93465  1.000 22.52687 ? 193  GLY A N   1 
ATOM   1568 C  CA  . GLY A 1 193 ? -35.61600 9.52820  -3.52670  1.000 20.80949 ? 193  GLY A CA  1 
ATOM   1569 C  C   . GLY A 1 193 ? -34.20242 9.25356  -3.99539  1.000 30.42567 ? 193  GLY A C   1 
ATOM   1570 O  O   . GLY A 1 193 ? -33.27814 10.06584 -3.85862  1.000 22.31565 ? 193  GLY A O   1 
ATOM   1571 N  N   . ASP A 1 194 ? -34.04845 8.06021  -4.58113  1.000 31.05847 ? 194  ASP A N   1 
ATOM   1572 C  CA  . ASP A 1 194 ? -32.73462 7.53455  -4.94050  1.000 29.94363 ? 194  ASP A CA  1 
ATOM   1573 C  C   . ASP A 1 194 ? -32.15598 8.18277  -6.18915  1.000 29.46398 ? 194  ASP A C   1 
ATOM   1574 O  O   . ASP A 1 194 ? -30.96438 8.00522  -6.46647  1.000 27.15746 ? 194  ASP A O   1 
ATOM   1575 C  CB  . ASP A 1 194 ? -32.81432 6.02161  -5.17022  1.000 34.76370 ? 194  ASP A CB  1 
ATOM   1576 C  CG  . ASP A 1 194 ? -33.12531 5.24653  -3.90458  1.000 44.16808 ? 194  ASP A CG  1 
ATOM   1577 O  OD1 . ASP A 1 194 ? -33.50171 4.05737  -4.02189  1.000 57.32040 ? 194  ASP A OD1 1 
ATOM   1578 O  OD2 . ASP A 1 194 ? -32.98163 5.81216  -2.79983  1.000 41.72841 ? 194  ASP A OD2 1 
ATOM   1579 N  N   . ASN A 1 195 ? -32.96545 8.90594  -6.95812  1.000 28.80868 ? 195  ASN A N   1 
ATOM   1580 C  CA  . ASN A 1 195 ? -32.52368 9.35997  -8.26700  1.000 31.00796 ? 195  ASN A CA  1 
ATOM   1581 C  C   . ASN A 1 195 ? -31.91827 10.76047 -8.27425  1.000 26.73218 ? 195  ASN A C   1 
ATOM   1582 O  O   . ASN A 1 195 ? -31.25740 11.11392 -9.25590  1.000 29.68515 ? 195  ASN A O   1 
ATOM   1583 C  CB  . ASN A 1 195 ? -33.68568 9.29923  -9.25821  1.000 29.99166 ? 195  ASN A CB  1 
ATOM   1584 C  CG  . ASN A 1 195 ? -34.09655 7.87243  -9.57833  1.000 43.61208 ? 195  ASN A CG  1 
ATOM   1585 O  OD1 . ASN A 1 195 ? -33.29089 6.93973  -9.47306  1.000 36.19066 ? 195  ASN A OD1 1 
ATOM   1586 N  ND2 . ASN A 1 195 ? -35.35403 7.69398  -9.96939  1.000 39.77379 ? 195  ASN A ND2 1 
ATOM   1587 N  N   . ILE A 1 196 ? -32.11827 11.57206 -7.22865  1.000 17.08796 ? 196  ILE A N   1 
ATOM   1588 C  CA  . ILE A 1 196 ? -31.42538 12.85717 -7.16650  1.000 16.88543 ? 196  ILE A CA  1 
ATOM   1589 C  C   . ILE A 1 196 ? -30.03276 12.63009 -6.58635  1.000 17.40095 ? 196  ILE A C   1 
ATOM   1590 O  O   . ILE A 1 196 ? -29.80721 11.70635 -5.79317  1.000 17.17148 ? 196  ILE A O   1 
ATOM   1591 C  CB  . ILE A 1 196 ? -32.22047 13.91301 -6.35851  1.000 16.14921 ? 196  ILE A CB  1 
ATOM   1592 C  CG1 . ILE A 1 196 ? -32.35805 13.51824 -4.89010  1.000 13.88960 ? 196  ILE A CG1 1 
ATOM   1593 C  CG2 . ILE A 1 196 ? -33.59590 14.17933 -6.97540  1.000 15.76269 ? 196  ILE A CG2 1 
ATOM   1594 C  CD1 . ILE A 1 196 ? -32.87481 14.65694 -4.01703  1.000 13.16982 ? 196  ILE A CD1 1 
ATOM   1595 N  N   . LYS A 1 197 ? -29.07617 13.46027 -6.99847  1.000 15.74171 ? 197  LYS A N   1 
ATOM   1596 C  CA  . LYS A 1 197 ? -27.68025 13.28155 -6.62475  1.000 14.34022 ? 197  LYS A CA  1 
ATOM   1597 C  C   . LYS A 1 197 ? -27.27197 14.41735 -5.69833  1.000 15.87766 ? 197  LYS A C   1 
ATOM   1598 O  O   . LYS A 1 197 ? -27.53076 15.58952 -5.99710  1.000 14.59078 ? 197  LYS A O   1 
ATOM   1599 C  CB  . LYS A 1 197 ? -26.78507 13.22728 -7.86872  1.000 16.01204 ? 197  LYS A CB  1 
ATOM   1600 C  CG  . LYS A 1 197 ? -27.14885 12.11203 -8.83620  1.000 20.09030 ? 197  LYS A CG  1 
ATOM   1601 C  CD  . LYS A 1 197 ? -26.65057 10.77609 -8.32404  1.000 20.18433 ? 197  LYS A CD  1 
ATOM   1602 C  CE  . LYS A 1 197 ? -27.38001 9.60847  -8.98727  1.000 33.07956 ? 197  LYS A CE  1 
ATOM   1603 N  NZ  . LYS A 1 197 ? -26.63949 8.33080  -8.74466  1.000 39.55770 ? 197  LYS A NZ  1 
ATOM   1604 N  N   . LEU A 1 198 ? -26.64175 14.06639 -4.58028  1.000 12.91109 ? 198  LEU A N   1 
ATOM   1605 C  CA  . LEU A 1 198 ? -26.46375 14.96356 -3.44542  1.000 15.47902 ? 198  LEU A CA  1 
ATOM   1606 C  C   . LEU A 1 198 ? -24.99384 15.33057 -3.29089  1.000 16.16939 ? 198  LEU A C   1 
ATOM   1607 O  O   . LEU A 1 198 ? -24.14468 14.44250 -3.18664  1.000 14.31320 ? 198  LEU A O   1 
ATOM   1608 C  CB  . LEU A 1 198 ? -26.98568 14.29621 -2.16523  1.000 16.08108 ? 198  LEU A CB  1 
ATOM   1609 C  CG  . LEU A 1 198 ? -28.39194 13.69169 -2.28749  1.000 18.11680 ? 198  LEU A CG  1 
ATOM   1610 C  CD1 . LEU A 1 198 ? -28.88227 13.07692 -0.95735  1.000 13.82348 ? 198  LEU A CD1 1 
ATOM   1611 C  CD2 . LEU A 1 198 ? -29.38319 14.75837 -2.77788  1.000 19.09073 ? 198  LEU A CD2 1 
ATOM   1612 N  N   . TYR A 1 199 ? -24.70262 16.63326 -3.23439  1.000 10.79494 ? 199  TYR A N   1 
ATOM   1613 C  CA  . TYR A 1 199 ? -23.33192 17.12239 -3.22476  1.000 12.18033 ? 199  TYR A CA  1 
ATOM   1614 C  C   . TYR A 1 199 ? -23.03937 17.97947 -2.00266  1.000 14.33060 ? 199  TYR A C   1 
ATOM   1615 O  O   . TYR A 1 199 ? -23.89375 18.72585 -1.51512  1.000 13.90377 ? 199  TYR A O   1 
ATOM   1616 C  CB  . TYR A 1 199 ? -23.01687 17.94809 -4.49246  1.000 13.54425 ? 199  TYR A CB  1 
ATOM   1617 C  CG  . TYR A 1 199 ? -23.01053 17.08619 -5.71634  1.000 14.13020 ? 199  TYR A CG  1 
ATOM   1618 C  CD1 . TYR A 1 199 ? -24.20427 16.64266 -6.25650  1.000 12.06060 ? 199  TYR A CD1 1 
ATOM   1619 C  CD2 . TYR A 1 199 ? -21.81634 16.68257 -6.31605  1.000 12.67211 ? 199  TYR A CD2 1 
ATOM   1620 C  CE1 . TYR A 1 199 ? -24.23367 15.83872 -7.35981  1.000 12.14468 ? 199  TYR A CE1 1 
ATOM   1621 C  CE2 . TYR A 1 199 ? -21.83742 15.85945 -7.43120  1.000 14.18882 ? 199  TYR A CE2 1 
ATOM   1622 C  CZ  . TYR A 1 199 ? -23.06364 15.44189 -7.93768  1.000 15.56276 ? 199  TYR A CZ  1 
ATOM   1623 O  OH  . TYR A 1 199 ? -23.14514 14.62275 -9.02991  1.000 15.23806 ? 199  TYR A OH  1 
ATOM   1624 N  N   . MET A 1 200 ? -21.80126 17.87401 -1.53256  1.000 12.58875 ? 200  MET A N   1 
ATOM   1625 C  CA  . MET A 1 200 ? -21.20942 18.84536 -0.62788  1.000 12.42319 ? 200  MET A CA  1 
ATOM   1626 C  C   . MET A 1 200 ? -20.35981 19.79339 -1.46858  1.000 13.65897 ? 200  MET A C   1 
ATOM   1627 O  O   . MET A 1 200 ? -19.40878 19.35738 -2.13182  1.000 15.72002 ? 200  MET A O   1 
ATOM   1628 C  CB  . MET A 1 200 ? -20.36769 18.15321 0.44670   1.000 15.59268 ? 200  MET A CB  1 
ATOM   1629 C  CG  . MET A 1 200 ? -19.68525 19.08770 1.42070   1.000 12.16785 ? 200  MET A CG  1 
ATOM   1630 S  SD  . MET A 1 200 ? -18.79326 18.15252 2.72400   1.000 19.45088 ? 200  MET A SD  1 
ATOM   1631 C  CE  . MET A 1 200 ? -20.13770 17.34977 3.57709   1.000 19.02559 ? 200  MET A CE  1 
ATOM   1632 N  N   . ASN A 1 201 ? -20.69571 21.08168 -1.42219  1.000 11.35932 ? 201  ASN A N   1 
ATOM   1633 C  CA  . ASN A 1 201 ? -20.11850 22.11167 -2.27501  1.000 13.71214 ? 201  ASN A CA  1 
ATOM   1634 C  C   . ASN A 1 201 ? -19.21215 23.00725 -1.43932  1.000 13.79225 ? 201  ASN A C   1 
ATOM   1635 O  O   . ASN A 1 201 ? -19.51770 23.29508 -0.28081  1.000 13.64200 ? 201  ASN A O   1 
ATOM   1636 C  CB  . ASN A 1 201 ? -21.23674 22.94528 -2.92622  1.000 12.11431 ? 201  ASN A CB  1 
ATOM   1637 C  CG  . ASN A 1 201 ? -20.74474 23.79971 -4.09097  1.000 12.09897 ? 201  ASN A CG  1 
ATOM   1638 O  OD1 . ASN A 1 201 ? -20.13702 23.29706 -5.03094  1.000 12.25342 ? 201  ASN A OD1 1 
ATOM   1639 N  ND2 . ASN A 1 201 ? -21.03592 25.09552 -4.04343  1.000 10.53102 ? 201  ASN A ND2 1 
ATOM   1640 N  N   . ASP A 1 202 ? -18.09389 23.44385 -2.01968  1.000 16.56781 ? 202  ASP A N   1 
ATOM   1641 C  CA  . ASP A 1 202 ? -17.15765 24.28213 -1.27845  1.000 13.77552 ? 202  ASP A CA  1 
ATOM   1642 C  C   . ASP A 1 202 ? -16.16946 24.92002 -2.24784  1.000 12.42121 ? 202  ASP A C   1 
ATOM   1643 O  O   . ASP A 1 202 ? -16.06064 24.52360 -3.41164  1.000 15.53140 ? 202  ASP A O   1 
ATOM   1644 C  CB  . ASP A 1 202 ? -16.41644 23.48579 -0.19704  1.000 12.09936 ? 202  ASP A CB  1 
ATOM   1645 C  CG  . ASP A 1 202 ? -16.25667 24.27587 1.08067   1.000 14.01330 ? 202  ASP A CG  1 
ATOM   1646 O  OD1 . ASP A 1 202 ? -16.03557 25.50226 0.96746   1.000 14.50815 ? 202  ASP A OD1 1 
ATOM   1647 O  OD2 . ASP A 1 202 ? -16.38022 23.68760 2.18299   1.000 14.48618 ? 202  ASP A OD2 1 
ATOM   1648 N  N   . TYR A 1 203 ? -15.47047 25.93778 -1.75574  1.000 13.94378 ? 203  TYR A N   1 
ATOM   1649 C  CA  . TYR A 1 203 ? -14.40688 26.61111 -2.48988  1.000 13.14569 ? 203  TYR A CA  1 
ATOM   1650 C  C   . TYR A 1 203 ? -13.06614 26.23373 -1.87795  1.000 15.35697 ? 203  TYR A C   1 
ATOM   1651 O  O   . TYR A 1 203 ? -12.99387 25.75157 -0.74314  1.000 14.36716 ? 203  TYR A O   1 
ATOM   1652 C  CB  . TYR A 1 203 ? -14.57758 28.13971 -2.46252  1.000 12.11888 ? 203  TYR A CB  1 
ATOM   1653 C  CG  . TYR A 1 203 ? -14.43126 28.74831 -1.07304  1.000 17.46527 ? 203  TYR A CG  1 
ATOM   1654 C  CD1 . TYR A 1 203 ? -13.17925 29.13330 -0.57990  1.000 15.77155 ? 203  TYR A CD1 1 
ATOM   1655 C  CD2 . TYR A 1 203 ? -15.54208 28.92826 -0.25365  1.000 16.06737 ? 203  TYR A CD2 1 
ATOM   1656 C  CE1 . TYR A 1 203 ? -13.04489 29.67779 0.69175   1.000 15.57110 ? 203  TYR A CE1 1 
ATOM   1657 C  CE2 . TYR A 1 203 ? -15.42423 29.48279 1.01699   1.000 20.24984 ? 203  TYR A CE2 1 
ATOM   1658 C  CZ  . TYR A 1 203 ? -14.16959 29.85041 1.48784   1.000 23.71648 ? 203  TYR A CZ  1 
ATOM   1659 O  OH  . TYR A 1 203 ? -14.04564 30.39105 2.75413   1.000 19.99952 ? 203  TYR A OH  1 
ATOM   1660 N  N   . ASN A 1 204 ? -12.00085 26.50108 -2.63094  1.000 15.05778 ? 204  ASN A N   1 
ATOM   1661 C  CA  . ASN A 1 204 ? -10.63549 26.19478 -2.19632  1.000 19.16982 ? 204  ASN A CA  1 
ATOM   1662 C  C   . ASN A 1 204 ? -10.51370 24.73073 -1.78545  1.000 16.54910 ? 204  ASN A C   1 
ATOM   1663 O  O   . ASN A 1 204 ? -9.80907  24.38501 -0.83790  1.000 18.52553 ? 204  ASN A O   1 
ATOM   1664 C  CB  . ASN A 1 204 ? -10.19586 27.12214 -1.06039  1.000 14.92516 ? 204  ASN A CB  1 
ATOM   1665 C  CG  . ASN A 1 204 ? -9.87958  28.52134 -1.54889  1.000 19.28882 ? 204  ASN A CG  1 
ATOM   1666 O  OD1 . ASN A 1 204 ? -10.09193 28.84199 -2.71558  1.000 17.86006 ? 204  ASN A OD1 1 
ATOM   1667 N  ND2 . ASN A 1 204 ? -9.36817  29.36194 -0.65842  1.000 19.16682 ? 204  ASN A ND2 1 
ATOM   1668 N  N   . THR A 1 205 ? -11.22575 23.86009 -2.50224  1.000 15.34953 ? 205  THR A N   1 
ATOM   1669 C  CA  . THR A 1 205 ? -11.17057 22.43653 -2.21001  1.000 14.84061 ? 205  THR A CA  1 
ATOM   1670 C  C   . THR A 1 205 ? -9.79143  21.84468 -2.46835  1.000 16.20316 ? 205  THR A C   1 
ATOM   1671 O  O   . THR A 1 205 ? -9.53372  20.72378 -2.02183  1.000 15.28148 ? 205  THR A O   1 
ATOM   1672 C  CB  . THR A 1 205 ? -12.21332 21.66671 -3.03002  1.000 14.44421 ? 205  THR A CB  1 
ATOM   1673 O  OG1 . THR A 1 205 ? -12.05232 21.95654 -4.42325  1.000 12.06767 ? 205  THR A OG1 1 
ATOM   1674 C  CG2 . THR A 1 205 ? -13.64248 22.01449 -2.58536  1.000 16.30122 ? 205  THR A CG2 1 
ATOM   1675 N  N   . GLU A 1 206 ? -8.91162  22.56585 -3.16778  1.000 15.46147 ? 206  GLU A N   1 
ATOM   1676 C  CA  . GLU A 1 206 ? -7.54616  22.12977 -3.45088  1.000 18.12699 ? 206  GLU A CA  1 
ATOM   1677 C  C   . GLU A 1 206 ? -6.56907  22.47279 -2.33848  1.000 21.20964 ? 206  GLU A C   1 
ATOM   1678 O  O   . GLU A 1 206 ? -5.43364  21.98938 -2.35993  1.000 24.83271 ? 206  GLU A O   1 
ATOM   1679 C  CB  . GLU A 1 206 ? -7.02461  22.78188 -4.74171  1.000 19.44372 ? 206  GLU A CB  1 
ATOM   1680 C  CG  . GLU A 1 206 ? -7.95322  22.70527 -5.94196  1.000 20.98141 ? 206  GLU A CG  1 
ATOM   1681 C  CD  . GLU A 1 206 ? -9.06966  23.72986 -5.90190  1.000 27.72897 ? 206  GLU A CD  1 
ATOM   1682 O  OE1 . GLU A 1 206 ? -9.01296  24.67547 -5.07113  1.000 23.73252 ? 206  GLU A OE1 1 
ATOM   1683 O  OE2 . GLU A 1 206 ? -10.01640 23.59064 -6.71080  1.000 32.18003 ? 206  GLU A OE2 1 
ATOM   1684 N  N   . VAL A 1 207 ? -6.96753  23.30431 -1.38641  1.000 22.60232 ? 207  VAL A N   1 
ATOM   1685 C  CA  . VAL A 1 207 ? -6.03515  23.97185 -0.48704  1.000 28.00048 ? 207  VAL A CA  1 
ATOM   1686 C  C   . VAL A 1 207 ? -6.00319  23.23699 0.84271   1.000 25.01978 ? 207  VAL A C   1 
ATOM   1687 O  O   . VAL A 1 207 ? -7.04006  23.08989 1.50449   1.000 22.31173 ? 207  VAL A O   1 
ATOM   1688 C  CB  . VAL A 1 207 ? -6.42217  25.44431 -0.29007  1.000 21.05709 ? 207  VAL A CB  1 
ATOM   1689 C  CG1 . VAL A 1 207 ? -5.43230  26.13275 0.64082   1.000 26.93856 ? 207  VAL A CG1 1 
ATOM   1690 C  CG2 . VAL A 1 207 ? -6.47150  26.13109 -1.63931  1.000 19.95115 ? 207  VAL A CG2 1 
ATOM   1691 N  N   . GLU A 1 208 ? -4.79365  22.78463 1.24973   1.000 20.04327 ? 208  GLU A N   1 
ATOM   1692 C  CA  . GLU A 1 208 ? -4.66100  22.23873 2.59188   1.000 24.99128 ? 208  GLU A CA  1 
ATOM   1693 C  C   . GLU A 1 208 ? -4.61153  23.37523 3.61437   1.000 18.46360 ? 208  GLU A C   1 
ATOM   1694 O  O   . GLU A 1 208 ? -4.07879  24.45123 3.33165   1.000 23.18714 ? 208  GLU A O   1 
ATOM   1695 C  CB  . GLU A 1 208 ? -3.40307  21.36973 2.70421   1.000 22.23520 ? 208  GLU A CB  1 
ATOM   1696 C  CG  . GLU A 1 208 ? -3.40113  20.12586 1.80917   1.000 20.32183 ? 208  GLU A CG  1 
ATOM   1697 C  CD  . GLU A 1 208 ? -4.45344  19.09663 2.20843   1.000 20.44628 ? 208  GLU A CD  1 
ATOM   1698 O  OE1 . GLU A 1 208 ? -5.15349  19.30128 3.21955   1.000 21.77537 ? 208  GLU A OE1 1 
ATOM   1699 O  OE2 . GLU A 1 208 ? -4.58687  18.07525 1.51414   1.000 24.26458 ? 208  GLU A OE2 1 
ATOM   1700 N  N   . PRO A 1 209 ? -5.14667  23.16116 4.83076   1.000 19.63758 ? 209  PRO A N   1 
ATOM   1701 C  CA  . PRO A 1 209 ? -5.69707  21.91451 5.36458   1.000 20.57541 ? 209  PRO A CA  1 
ATOM   1702 C  C   . PRO A 1 209 ? -7.18518  21.69549 5.04571   1.000 21.74800 ? 209  PRO A C   1 
ATOM   1703 O  O   . PRO A 1 209 ? -7.74008  20.68786 5.48932   1.000 20.28439 ? 209  PRO A O   1 
ATOM   1704 C  CB  . PRO A 1 209 ? -5.49454  22.08046 6.87327   1.000 23.09588 ? 209  PRO A CB  1 
ATOM   1705 C  CG  . PRO A 1 209 ? -5.67133  23.54485 7.09071   1.000 18.75784 ? 209  PRO A CG  1 
ATOM   1706 C  CD  . PRO A 1 209 ? -5.08473  24.21012 5.86499   1.000 17.59159 ? 209  PRO A CD  1 
ATOM   1707 N  N   . LYS A 1 210 ? -7.81211  22.61401 4.30229   1.000 19.99146 ? 210  LYS A N   1 
ATOM   1708 C  CA  . LYS A 1 210 ? -9.23565  22.45707 3.98664   1.000 19.30323 ? 210  LYS A CA  1 
ATOM   1709 C  C   . LYS A 1 210 ? -9.50272  21.16304 3.22560   1.000 15.45374 ? 210  LYS A C   1 
ATOM   1710 O  O   . LYS A 1 210 ? -10.45410 20.43384 3.53550   1.000 20.89280 ? 210  LYS A O   1 
ATOM   1711 C  CB  . LYS A 1 210 ? -9.72941  23.65850 3.18591   1.000 18.65454 ? 210  LYS A CB  1 
ATOM   1712 C  CG  . LYS A 1 210 ? -11.21399 23.64687 2.88930   1.000 19.12250 ? 210  LYS A CG  1 
ATOM   1713 C  CD  . LYS A 1 210 ? -11.59549 24.93043 2.18032   1.000 18.29555 ? 210  LYS A CD  1 
ATOM   1714 C  CE  . LYS A 1 210 ? -13.00211 25.39351 2.55662   1.000 16.68431 ? 210  LYS A CE  1 
ATOM   1715 N  NZ  . LYS A 1 210 ? -13.29620 26.75025 1.97444   1.000 15.73633 ? 210  LYS A NZ  1 
ATOM   1716 N  N   . ARG A 1 211 ? -8.65352  20.84970 2.24993   1.000 18.60465 ? 211  ARG A N   1 
ATOM   1717 C  CA  . ARG A 1 211 ? -8.87945  19.69249 1.39171   1.000 17.85117 ? 211  ARG A CA  1 
ATOM   1718 C  C   . ARG A 1 211 ? -8.94648  18.40092 2.19509   1.000 23.39902 ? 211  ARG A C   1 
ATOM   1719 O  O   . ARG A 1 211 ? -9.83551  17.57046 1.98405   1.000 18.40055 ? 211  ARG A O   1 
ATOM   1720 C  CB  . ARG A 1 211 ? -7.77220  19.59415 0.33722   1.000 19.14210 ? 211  ARG A CB  1 
ATOM   1721 C  CG  . ARG A 1 211 ? -7.81578  18.27800 -0.43524  1.000 18.00860 ? 211  ARG A CG  1 
ATOM   1722 C  CD  . ARG A 1 211 ? -6.89040  18.27121 -1.63336  1.000 19.81810 ? 211  ARG A CD  1 
ATOM   1723 N  NE  . ARG A 1 211 ? -5.48765  18.38493 -1.23963  1.000 21.22658 ? 211  ARG A NE  1 
ATOM   1724 C  CZ  . ARG A 1 211 ? -4.50203  18.67817 -2.08534  1.000 21.53734 ? 211  ARG A CZ  1 
ATOM   1725 N  NH1 . ARG A 1 211 ? -4.76553  18.87921 -3.37456  1.000 16.68094 ? 211  ARG A NH1 1 
ATOM   1726 N  NH2 . ARG A 1 211 ? -3.25475  18.76953 -1.64385  1.000 18.90054 ? 211  ARG A NH2 1 
ATOM   1727 N  N   . THR A 1 212 ? -7.98109  18.18665 3.08709   1.000 20.87220 ? 212  THR A N   1 
ATOM   1728 C  CA  . THR A 1 212 ? -7.97873  16.94727 3.84987   1.000 19.59437 ? 212  THR A CA  1 
ATOM   1729 C  C   . THR A 1 212 ? -9.12042  16.92477 4.85437   1.000 19.89010 ? 212  THR A C   1 
ATOM   1730 O  O   . THR A 1 212 ? -9.69523  15.86488 5.12344   1.000 20.87388 ? 212  THR A O   1 
ATOM   1731 C  CB  . THR A 1 212 ? -6.62749  16.76585 4.54100   1.000 28.89538 ? 212  THR A CB  1 
ATOM   1732 O  OG1 . THR A 1 212 ? -5.61644  16.63659 3.53571   1.000 25.94438 ? 212  THR A OG1 1 
ATOM   1733 C  CG2 . THR A 1 212 ? -6.61893  15.50351 5.41395   1.000 23.26206 ? 212  THR A CG2 1 
ATOM   1734 N  N   . ALA A 1 213 ? -9.46757  18.08805 5.41010   1.000 24.16341 ? 213  ALA A N   1 
ATOM   1735 C  CA  . ALA A 1 213 ? -10.62051 18.16855 6.29877   1.000 23.15420 ? 213  ALA A CA  1 
ATOM   1736 C  C   . ALA A 1 213 ? -11.89789 17.77949 5.56374   1.000 20.66020 ? 213  ALA A C   1 
ATOM   1737 O  O   . ALA A 1 213 ? -12.70867 16.99504 6.07602   1.000 18.55522 ? 213  ALA A O   1 
ATOM   1738 C  CB  . ALA A 1 213 ? -10.73592 19.58023 6.87901   1.000 18.82474 ? 213  ALA A CB  1 
ATOM   1739 N  N   . LEU A 1 214 ? -12.08291 18.30805 4.35079   1.000 19.63127 ? 214  LEU A N   1 
ATOM   1740 C  CA  . LEU A 1 214 ? -13.20945 17.89799 3.51388   1.000 21.48070 ? 214  LEU A CA  1 
ATOM   1741 C  C   . LEU A 1 214 ? -13.16844 16.40371 3.24097   1.000 20.56114 ? 214  LEU A C   1 
ATOM   1742 O  O   . LEU A 1 214 ? -14.18337 15.70610 3.36357   1.000 15.73333 ? 214  LEU A O   1 
ATOM   1743 C  CB  . LEU A 1 214 ? -13.19169 18.66235 2.19264   1.000 17.64104 ? 214  LEU A CB  1 
ATOM   1744 C  CG  . LEU A 1 214 ? -13.91925 19.99090 2.18836   1.000 29.01166 ? 214  LEU A CG  1 
ATOM   1745 C  CD1 . LEU A 1 214 ? -13.33307 20.92572 1.11374   1.000 27.24430 ? 214  LEU A CD1 1 
ATOM   1746 C  CD2 . LEU A 1 214 ? -15.40201 19.73022 1.97381   1.000 26.19554 ? 214  LEU A CD2 1 
ATOM   1747 N  N   . TYR A 1 215 ? -11.99390 15.89921 2.85787   1.000 20.20551 ? 215  TYR A N   1 
ATOM   1748 C  CA  . TYR A 1 215 ? -11.81306 14.46951 2.63187   1.000 19.47227 ? 215  TYR A CA  1 
ATOM   1749 C  C   . TYR A 1 215 ? -12.24917 13.65126 3.84442   1.000 20.96634 ? 215  TYR A C   1 
ATOM   1750 O  O   . TYR A 1 215 ? -13.06775 12.73197 3.72664   1.000 19.54865 ? 215  TYR A O   1 
ATOM   1751 C  CB  . TYR A 1 215 ? -10.34577 14.19030 2.29627   1.000 22.65523 ? 215  TYR A CB  1 
ATOM   1752 C  CG  . TYR A 1 215 ? -10.07274 12.74934 1.97342   1.000 20.19167 ? 215  TYR A CG  1 
ATOM   1753 C  CD1 . TYR A 1 215 ? -10.33877 12.24413 0.70766   1.000 23.69668 ? 215  TYR A CD1 1 
ATOM   1754 C  CD2 . TYR A 1 215 ? -9.55186  11.88699 2.93209   1.000 27.23382 ? 215  TYR A CD2 1 
ATOM   1755 C  CE1 . TYR A 1 215 ? -10.09378 10.91439 0.40335   1.000 24.14092 ? 215  TYR A CE1 1 
ATOM   1756 C  CE2 . TYR A 1 215 ? -9.30464  10.55175 2.63971   1.000 23.16726 ? 215  TYR A CE2 1 
ATOM   1757 C  CZ  . TYR A 1 215 ? -9.57821  10.07572 1.37562   1.000 25.54311 ? 215  TYR A CZ  1 
ATOM   1758 O  OH  . TYR A 1 215 ? -9.33936  8.75454  1.07642   1.000 31.29397 ? 215  TYR A OH  1 
ATOM   1759 N  N   . ASN A 1 216 ? -11.70450 13.97257 5.02222   1.000 19.62181 ? 216  ASN A N   1 
ATOM   1760 C  CA  . ASN A 1 216 ? -12.01895 13.20016 6.22065   1.000 18.26334 ? 216  ASN A CA  1 
ATOM   1761 C  C   . ASN A 1 216 ? -13.50135 13.27434 6.56138   1.000 25.22870 ? 216  ASN A C   1 
ATOM   1762 O  O   . ASN A 1 216 ? -14.11192 12.26487 6.94313   1.000 21.59875 ? 216  ASN A O   1 
ATOM   1763 C  CB  . ASN A 1 216 ? -11.18854 13.70345 7.39614   1.000 22.81916 ? 216  ASN A CB  1 
ATOM   1764 C  CG  . ASN A 1 216 ? -9.70678  13.44605 7.21743   1.000 26.59611 ? 216  ASN A CG  1 
ATOM   1765 O  OD1 . ASN A 1 216 ? -9.29902  12.56970 6.45167   1.000 22.22321 ? 216  ASN A OD1 1 
ATOM   1766 N  ND2 . ASN A 1 216 ? -8.89032  14.21900 7.92580   1.000 23.98049 ? 216  ASN A ND2 1 
ATOM   1767 N  N   . LEU A 1 217 ? -14.09702 14.46267 6.43343   1.000 23.95443 ? 217  LEU A N   1 
ATOM   1768 C  CA  . LEU A 1 217 ? -15.50979 14.62373 6.76735   1.000 20.11463 ? 217  LEU A CA  1 
ATOM   1769 C  C   . LEU A 1 217 ? -16.38452 13.74836 5.88432   1.000 21.37724 ? 217  LEU A C   1 
ATOM   1770 O  O   . LEU A 1 217 ? -17.23339 12.99618 6.37849   1.000 24.18914 ? 217  LEU A O   1 
ATOM   1771 C  CB  . LEU A 1 217 ? -15.91365 16.09269 6.64539   1.000 20.86892 ? 217  LEU A CB  1 
ATOM   1772 C  CG  . LEU A 1 217 ? -17.41089 16.41303 6.78756   1.000 19.64166 ? 217  LEU A CG  1 
ATOM   1773 C  CD1 . LEU A 1 217 ? -17.93650 16.09201 8.19254   1.000 23.28581 ? 217  LEU A CD1 1 
ATOM   1774 C  CD2 . LEU A 1 217 ? -17.66867 17.86228 6.44804   1.000 16.87630 ? 217  LEU A CD2 1 
ATOM   1775 N  N   . VAL A 1 218 ? -16.18091 13.81632 4.56810   1.000 22.68763 ? 218  VAL A N   1 
ATOM   1776 C  CA  . VAL A 1 218 ? -17.00880 13.02852 3.66030   1.000 20.39639 ? 218  VAL A CA  1 
ATOM   1777 C  C   . VAL A 1 218 ? -16.79020 11.53864 3.88198   1.000 24.23729 ? 218  VAL A C   1 
ATOM   1778 O  O   . VAL A 1 218 ? -17.74366 10.74823 3.87837   1.000 18.10962 ? 218  VAL A O   1 
ATOM   1779 C  CB  . VAL A 1 218 ? -16.73453 13.42392 2.19847   1.000 21.85425 ? 218  VAL A CB  1 
ATOM   1780 C  CG1 . VAL A 1 218 ? -17.43432 12.46227 1.29205   1.000 29.58774 ? 218  VAL A CG1 1 
ATOM   1781 C  CG2 . VAL A 1 218 ? -17.23680 14.82971 1.93686   1.000 23.04586 ? 218  VAL A CG2 1 
ATOM   1782 N  N   . LYS A 1 219 ? -15.52944 11.12536 4.04716   1.000 27.70998 ? 219  LYS A N   1 
ATOM   1783 C  CA  . LYS A 1 219 ? -15.23875 9.71798  4.30660   1.000 23.33794 ? 219  LYS A CA  1 
ATOM   1784 C  C   . LYS A 1 219 ? -15.98908 9.22955  5.53915   1.000 24.21167 ? 219  LYS A C   1 
ATOM   1785 O  O   . LYS A 1 219 ? -16.58816 8.14812  5.53006   1.000 25.34905 ? 219  LYS A O   1 
ATOM   1786 C  CB  . LYS A 1 219 ? -13.72740 9.51607  4.47090   1.000 25.21573 ? 219  LYS A CB  1 
ATOM   1787 C  CG  . LYS A 1 219 ? -13.31679 8.06078  4.64614   1.000 32.12901 ? 219  LYS A CG  1 
ATOM   1788 C  CD  . LYS A 1 219 ? -11.83093 7.84451  4.37207   1.000 35.23099 ? 219  LYS A CD  1 
ATOM   1789 C  CE  . LYS A 1 219 ? -11.27262 6.67896  5.18069   1.000 39.39181 ? 219  LYS A CE  1 
ATOM   1790 N  NZ  . LYS A 1 219 ? -11.86050 6.61129  6.55275   1.000 51.48454 ? 219  LYS A NZ  1 
ATOM   1791 N  N   . GLN A 1 220 ? -15.97902 10.02807 6.60794   1.000 22.71474 ? 220  GLN A N   1 
ATOM   1792 C  CA  . GLN A 1 220 ? -16.65542 9.63889  7.84112   1.000 29.52293 ? 220  GLN A CA  1 
ATOM   1793 C  C   . GLN A 1 220 ? -18.16515 9.57684  7.64542   1.000 32.77097 ? 220  GLN A C   1 
ATOM   1794 O  O   . GLN A 1 220 ? -18.81931 8.62723  8.09238   1.000 32.34720 ? 220  GLN A O   1 
ATOM   1795 C  CB  . GLN A 1 220 ? -16.29024 10.61512 8.96247   1.000 28.07222 ? 220  GLN A CB  1 
ATOM   1796 C  CG  . GLN A 1 220 ? -17.11716 10.46791 10.23892  1.000 43.60697 ? 220  GLN A CG  1 
ATOM   1797 C  CD  . GLN A 1 220 ? -16.99012 11.67432 11.16783  1.000 48.86318 ? 220  GLN A CD  1 
ATOM   1798 O  OE1 . GLN A 1 220 ? -16.23348 12.60909 10.89553  1.000 55.42744 ? 220  GLN A OE1 1 
ATOM   1799 N  NE2 . GLN A 1 220 ? -17.74621 11.66433 12.25849  1.000 49.32499 ? 220  GLN A NE2 1 
ATOM   1800 N  N   . LEU A 1 221 ? -18.73696 10.58024 6.97175   1.000 29.98834 ? 221  LEU A N   1 
ATOM   1801 C  CA  . LEU A 1 221 ? -20.18154 10.59820 6.76541   1.000 26.55796 ? 221  LEU A CA  1 
ATOM   1802 C  C   . LEU A 1 221 ? -20.64155 9.40366  5.94167   1.000 26.68718 ? 221  LEU A C   1 
ATOM   1803 O  O   . LEU A 1 221 ? -21.69353 8.81853  6.22405   1.000 28.37720 ? 221  LEU A O   1 
ATOM   1804 C  CB  . LEU A 1 221 ? -20.60342 11.91276 6.10488   1.000 26.46684 ? 221  LEU A CB  1 
ATOM   1805 C  CG  . LEU A 1 221 ? -20.37504 13.16961 6.94589   1.000 31.06287 ? 221  LEU A CG  1 
ATOM   1806 C  CD1 . LEU A 1 221 ? -20.80918 14.41485 6.20026   1.000 32.26269 ? 221  LEU A CD1 1 
ATOM   1807 C  CD2 . LEU A 1 221 ? -21.11186 13.06143 8.27050   1.000 30.22808 ? 221  LEU A CD2 1 
ATOM   1808 N  N   . LYS A 1 222 ? -19.86027 9.00321  4.93705   1.000 23.77181 ? 222  LYS A N   1 
ATOM   1809 C  CA  . LYS A 1 222 ? -20.28056 7.85219  4.14970   1.000 27.82497 ? 222  LYS A CA  1 
ATOM   1810 C  C   . LYS A 1 222 ? -20.06115 6.54273  4.89931   1.000 37.25291 ? 222  LYS A C   1 
ATOM   1811 O  O   . LYS A 1 222 ? -20.78052 5.56342  4.66250   1.000 32.32590 ? 222  LYS A O   1 
ATOM   1812 C  CB  . LYS A 1 222 ? -19.57191 7.82330  2.80238   1.000 28.61049 ? 222  LYS A CB  1 
ATOM   1813 C  CG  . LYS A 1 222 ? -20.46499 8.41598  1.74765   1.000 38.03138 ? 222  LYS A CG  1 
ATOM   1814 C  CD  . LYS A 1 222 ? -20.38355 7.77451  0.37302   1.000 40.21426 ? 222  LYS A CD  1 
ATOM   1815 C  CE  . LYS A 1 222 ? -19.09690 8.10316  -0.32318  1.000 38.48013 ? 222  LYS A CE  1 
ATOM   1816 N  NZ  . LYS A 1 222 ? -18.82413 7.04452  -1.32395  1.000 43.57498 ? 222  LYS A NZ  1 
ATOM   1817 N  N   . GLU A 1 223 ? -19.08987 6.50059  5.81394   1.000 32.73037 ? 223  GLU A N   1 
ATOM   1818 C  CA  . GLU A 1 223 ? -18.96106 5.32464  6.66503   1.000 33.90087 ? 223  GLU A CA  1 
ATOM   1819 C  C   . GLU A 1 223 ? -20.17017 5.18319  7.57371   1.000 29.88471 ? 223  GLU A C   1 
ATOM   1820 O  O   . GLU A 1 223 ? -20.61194 4.06467  7.84852   1.000 36.47956 ? 223  GLU A O   1 
ATOM   1821 C  CB  . GLU A 1 223 ? -17.67273 5.40333  7.47717   1.000 31.14669 ? 223  GLU A CB  1 
ATOM   1822 C  CG  . GLU A 1 223 ? -16.45268 5.04926  6.65578   1.000 39.45973 ? 223  GLU A CG  1 
ATOM   1823 C  CD  . GLU A 1 223 ? -15.16175 5.33981  7.38071   1.000 40.30405 ? 223  GLU A CD  1 
ATOM   1824 O  OE1 . GLU A 1 223 ? -15.22019 5.88092  8.50653   1.000 49.17670 ? 223  GLU A OE1 1 
ATOM   1825 O  OE2 . GLU A 1 223 ? -14.09172 5.02845  6.81612   1.000 45.27142 ? 223  GLU A OE2 1 
ATOM   1826 N  N   . GLU A 1 224 ? -20.72698 6.30580  8.03532   1.000 29.37933 ? 224  GLU A N   1 
ATOM   1827 C  CA  . GLU A 1 224 ? -21.93446 6.31102  8.85588   1.000 30.36970 ? 224  GLU A CA  1 
ATOM   1828 C  C   . GLU A 1 224 ? -23.21398 6.17110  8.04373   1.000 29.74379 ? 224  GLU A C   1 
ATOM   1829 O  O   . GLU A 1 224 ? -24.29945 6.26735  8.62095   1.000 32.70330 ? 224  GLU A O   1 
ATOM   1830 C  CB  . GLU A 1 224 ? -22.01678 7.59793  9.67977   1.000 30.24764 ? 224  GLU A CB  1 
ATOM   1831 C  CG  . GLU A 1 224 ? -20.79546 7.87737  10.51783  1.000 33.07364 ? 224  GLU A CG  1 
ATOM   1832 C  CD  . GLU A 1 224 ? -20.98961 9.06297  11.42378  1.000 36.92999 ? 224  GLU A CD  1 
ATOM   1833 O  OE1 . GLU A 1 224 ? -22.11358 9.61079  11.45278  1.000 44.08263 ? 224  GLU A OE1 1 
ATOM   1834 O  OE2 . GLU A 1 224 ? -20.02047 9.44482  12.11036  1.000 39.18922 ? 224  GLU A OE2 1 
ATOM   1835 N  N   . GLY A 1 225 ? -23.12340 5.97123  6.73158   1.000 29.02961 ? 225  GLY A N   1 
ATOM   1836 C  CA  . GLY A 1 225 ? -24.31339 5.82055  5.91860   1.000 31.06718 ? 225  GLY A CA  1 
ATOM   1837 C  C   . GLY A 1 225 ? -25.03419 7.10187  5.55811   1.000 31.23244 ? 225  GLY A C   1 
ATOM   1838 O  O   . GLY A 1 225 ? -26.15711 7.03349  5.04745   1.000 30.67534 ? 225  GLY A O   1 
ATOM   1839 N  N   . VAL A 1 226 ? -24.44622 8.26401  5.80606   1.000 24.62275 ? 226  VAL A N   1 
ATOM   1840 C  CA  . VAL A 1 226 ? -25.07390 9.49887  5.32018   1.000 24.35456 ? 226  VAL A CA  1 
ATOM   1841 C  C   . VAL A 1 226 ? -25.01139 9.51711  3.79541   1.000 26.59979 ? 226  VAL A C   1 
ATOM   1842 O  O   . VAL A 1 226 ? -23.93547 9.27259  3.21938   1.000 26.22573 ? 226  VAL A O   1 
ATOM   1843 C  CB  . VAL A 1 226 ? -24.38212 10.72360 5.91651   1.000 24.09146 ? 226  VAL A CB  1 
ATOM   1844 C  CG1 . VAL A 1 226 ? -24.99849 12.00538 5.37180   1.000 16.00450 ? 226  VAL A CG1 1 
ATOM   1845 C  CG2 . VAL A 1 226 ? -24.47283 10.70676 7.43055   1.000 24.95802 ? 226  VAL A CG2 1 
ATOM   1846 N  N   . PRO A 1 227 ? -26.11660 9.78428  3.09614   1.000 21.19855 ? 227  PRO A N   1 
ATOM   1847 C  CA  . PRO A 1 227 ? -26.09514 9.71901  1.62331   1.000 23.08421 ? 227  PRO A CA  1 
ATOM   1848 C  C   . PRO A 1 227 ? -25.41545 10.94486 1.02307   1.000 22.84456 ? 227  PRO A C   1 
ATOM   1849 O  O   . PRO A 1 227 ? -25.91448 12.06591 1.14369   1.000 29.36979 ? 227  PRO A O   1 
ATOM   1850 C  CB  . PRO A 1 227 ? -27.58340 9.65638  1.25528   1.000 19.78825 ? 227  PRO A CB  1 
ATOM   1851 C  CG  . PRO A 1 227 ? -28.26839 10.37208 2.38135   1.000 19.78991 ? 227  PRO A CG  1 
ATOM   1852 C  CD  . PRO A 1 227 ? -27.46081 10.09240 3.62627   1.000 20.18170 ? 227  PRO A CD  1 
ATOM   1853 N  N   . ILE A 1 228 ? -24.26541 10.74498 0.38092   1.000 20.87542 ? 228  ILE A N   1 
ATOM   1854 C  CA  . ILE A 1 228 ? -23.60043 11.83617 -0.32840  1.000 21.71067 ? 228  ILE A CA  1 
ATOM   1855 C  C   . ILE A 1 228 ? -22.98230 11.27796 -1.60406  1.000 21.50476 ? 228  ILE A C   1 
ATOM   1856 O  O   . ILE A 1 228 ? -22.19449 10.32591 -1.55647  1.000 21.56588 ? 228  ILE A O   1 
ATOM   1857 C  CB  . ILE A 1 228 ? -22.54425 12.55370 0.53304   1.000 20.20506 ? 228  ILE A CB  1 
ATOM   1858 C  CG1 . ILE A 1 228 ? -21.68785 13.48404 -0.33077  1.000 15.38981 ? 228  ILE A CG1 1 
ATOM   1859 C  CG2 . ILE A 1 228 ? -21.66790 11.57055 1.23928   1.000 27.32784 ? 228  ILE A CG2 1 
ATOM   1860 C  CD1 . ILE A 1 228 ? -20.91441 14.47875 0.46868   1.000 23.75931 ? 228  ILE A CD1 1 
ATOM   1861 N  N   . ASP A 1 229 ? -23.35274 11.85532 -2.74810  1.000 15.26519 ? 229  ASP A N   1 
ATOM   1862 C  CA  . ASP A 1 229 ? -22.94109 11.30830 -4.02864  1.000 16.43919 ? 229  ASP A CA  1 
ATOM   1863 C  C   . ASP A 1 229 ? -21.71887 11.99697 -4.62227  1.000 16.36179 ? 229  ASP A C   1 
ATOM   1864 O  O   . ASP A 1 229 ? -21.03290 11.38772 -5.44230  1.000 14.70576 ? 229  ASP A O   1 
ATOM   1865 C  CB  . ASP A 1 229 ? -24.10657 11.38643 -5.01678  1.000 13.97956 ? 229  ASP A CB  1 
ATOM   1866 C  CG  . ASP A 1 229 ? -25.33205 10.66220 -4.49847  1.000 21.47932 ? 229  ASP A CG  1 
ATOM   1867 O  OD1 . ASP A 1 229 ? -25.19754 9.45419  -4.19177  1.000 20.66396 ? 229  ASP A OD1 1 
ATOM   1868 O  OD2 . ASP A 1 229 ? -26.40591 11.29401 -4.37929  1.000 17.29860 ? 229  ASP A OD2 1 
ATOM   1869 N  N   . GLY A 1 230 ? -21.43063 13.23921 -4.24711  1.000 13.19597 ? 230  GLY A N   1 
ATOM   1870 C  CA  . GLY A 1 230 ? -20.32291 13.90131 -4.90881  1.000 13.83803 ? 230  GLY A CA  1 
ATOM   1871 C  C   . GLY A 1 230 ? -19.83373 15.12313 -4.16362  1.000 16.42650 ? 230  GLY A C   1 
ATOM   1872 O  O   . GLY A 1 230 ? -20.39815 15.53473 -3.14596  1.000 14.34480 ? 230  GLY A O   1 
ATOM   1873 N  N   . ILE A 1 231 ? -18.75091 15.69166 -4.69385  1.000 13.76348 ? 231  ILE A N   1 
ATOM   1874 C  CA  . ILE A 1 231 ? -18.17011 16.93498 -4.20331  1.000 13.69471 ? 231  ILE A CA  1 
ATOM   1875 C  C   . ILE A 1 231 ? -18.37841 18.00948 -5.26180  1.000 14.98859 ? 231  ILE A C   1 
ATOM   1876 O  O   . ILE A 1 231 ? -18.07787 17.78577 -6.44357  1.000 13.31530 ? 231  ILE A O   1 
ATOM   1877 C  CB  . ILE A 1 231 ? -16.66866 16.78547 -3.89851  1.000 12.13357 ? 231  ILE A CB  1 
ATOM   1878 C  CG1 . ILE A 1 231 ? -16.45144 15.72397 -2.81931  1.000 16.27376 ? 231  ILE A CG1 1 
ATOM   1879 C  CG2 . ILE A 1 231 ? -16.09303 18.14477 -3.48406  1.000 12.42183 ? 231  ILE A CG2 1 
ATOM   1880 C  CD1 . ILE A 1 231 ? -17.11957 16.05612 -1.48642  1.000 19.12629 ? 231  ILE A CD1 1 
ATOM   1881 N  N   . GLY A 1 232 ? -18.88085 19.17134 -4.83969  1.000 13.57989 ? 232  GLY A N   1 
ATOM   1882 C  CA  . GLY A 1 232 ? -18.88385 20.34662 -5.69580  1.000 13.80888 ? 232  GLY A CA  1 
ATOM   1883 C  C   . GLY A 1 232 ? -17.65880 21.20784 -5.47170  1.000 12.54736 ? 232  GLY A C   1 
ATOM   1884 O  O   . GLY A 1 232 ? -17.41006 21.62252 -4.33834  1.000 11.32220 ? 232  GLY A O   1 
ATOM   1885 N  N   . HIS A 1 233 ? -16.87171 21.45740 -6.53089  1.000 8.60995  ? 233  HIS A N   1 
ATOM   1886 C  CA  . HIS A 1 233 ? -15.69170 22.32118 -6.47392  1.000 11.82186 ? 233  HIS A CA  1 
ATOM   1887 C  C   . HIS A 1 233 ? -16.06711 23.67102 -7.07864  1.000 13.72824 ? 233  HIS A C   1 
ATOM   1888 O  O   . HIS A 1 233 ? -16.20459 23.79322 -8.30466  1.000 12.31689 ? 233  HIS A O   1 
ATOM   1889 C  CB  . HIS A 1 233 ? -14.50673 21.70171 -7.22342  1.000 12.77686 ? 233  HIS A CB  1 
ATOM   1890 C  CG  . HIS A 1 233 ? -14.23044 20.27592 -6.84225  1.000 13.29411 ? 233  HIS A CG  1 
ATOM   1891 N  ND1 . HIS A 1 233 ? -13.28676 19.92769 -5.90017  1.000 14.37448 ? 233  HIS A ND1 1 
ATOM   1892 C  CD2 . HIS A 1 233 ? -14.79859 19.11527 -7.25104  1.000 14.97757 ? 233  HIS A CD2 1 
ATOM   1893 C  CE1 . HIS A 1 233 ? -13.27735 18.61512 -5.75008  1.000 13.89178 ? 233  HIS A CE1 1 
ATOM   1894 N  NE2 . HIS A 1 233 ? -14.18009 18.09639 -6.56353  1.000 13.52679 ? 233  HIS A NE2 1 
ATOM   1895 N  N   . GLN A 1 234 ? -16.22449 24.68318 -6.22028  1.000 11.43012 ? 234  GLN A N   1 
ATOM   1896 C  CA  . GLN A 1 234 ? -16.64636 25.99651 -6.70409  1.000 11.02834 ? 234  GLN A CA  1 
ATOM   1897 C  C   . GLN A 1 234 ? -15.67309 26.52161 -7.74413  1.000 13.73223 ? 234  GLN A C   1 
ATOM   1898 O  O   . GLN A 1 234 ? -16.08707 27.15292 -8.72104  1.000 11.67899 ? 234  GLN A O   1 
ATOM   1899 C  CB  . GLN A 1 234 ? -16.77879 26.98210 -5.53980  1.000 11.14336 ? 234  GLN A CB  1 
ATOM   1900 C  CG  . GLN A 1 234 ? -18.05645 26.80792 -4.70231  1.000 10.92710 ? 234  GLN A CG  1 
ATOM   1901 C  CD  . GLN A 1 234 ? -18.19916 27.86855 -3.60789  1.000 15.61913 ? 234  GLN A CD  1 
ATOM   1902 O  OE1 . GLN A 1 234 ? -17.69917 28.97967 -3.74482  1.000 15.22401 ? 234  GLN A OE1 1 
ATOM   1903 N  NE2 . GLN A 1 234 ? -18.89000 27.52158 -2.51819  1.000 11.88471 ? 234  GLN A NE2 1 
ATOM   1904 N  N   . SER A 1 235 ? -14.37430 26.25232 -7.56060  1.000 10.08599 ? 235  SER A N   1 
ATOM   1905 C  CA  . SER A 1 235 ? -13.34780 26.61476 -8.54316  1.000 12.72019 ? 235  SER A CA  1 
ATOM   1906 C  C   . SER A 1 235 ? -13.36742 28.11350 -8.85394  1.000 12.63787 ? 235  SER A C   1 
ATOM   1907 O  O   . SER A 1 235 ? -13.33442 28.53992 -10.01288 1.000 11.70570 ? 235  SER A O   1 
ATOM   1908 C  CB  . SER A 1 235 ? -13.50317 25.78770 -9.82169  1.000 12.29951 ? 235  SER A CB  1 
ATOM   1909 O  OG  . SER A 1 235 ? -13.57947 24.39841 -9.51622  1.000 15.08828 ? 235  SER A OG  1 
ATOM   1910 N  N   . HIS A 1 236 ? -13.41851 28.92734 -7.80482  1.000 9.70957  ? 236  HIS A N   1 
ATOM   1911 C  CA  . HIS A 1 236 ? -13.20812 30.36095 -7.99081  1.000 12.53171 ? 236  HIS A CA  1 
ATOM   1912 C  C   . HIS A 1 236 ? -11.69940 30.56579 -7.98385  1.000 11.71816 ? 236  HIS A C   1 
ATOM   1913 O  O   . HIS A 1 236 ? -11.06618 30.69409 -6.93384  1.000 14.25266 ? 236  HIS A O   1 
ATOM   1914 C  CB  . HIS A 1 236 ? -13.91385 31.17667 -6.91158  1.000 14.69115 ? 236  HIS A CB  1 
ATOM   1915 C  CG  . HIS A 1 236 ? -15.40459 31.07239 -6.96527  1.000 15.04938 ? 236  HIS A CG  1 
ATOM   1916 N  ND1 . HIS A 1 236 ? -16.14136 31.47117 -8.06297  1.000 14.75531 ? 236  HIS A ND1 1 
ATOM   1917 C  CD2 . HIS A 1 236 ? -16.29673 30.61825 -6.05485  1.000 14.27199 ? 236  HIS A CD2 1 
ATOM   1918 C  CE1 . HIS A 1 236 ? -17.42171 31.24648 -7.83093  1.000 14.97308 ? 236  HIS A CE1 1 
ATOM   1919 N  NE2 . HIS A 1 236 ? -17.54432 30.73317 -6.61978  1.000 15.62025 ? 236  HIS A NE2 1 
ATOM   1920 N  N   . ILE A 1 237 ? -11.10733 30.57611 -9.17531  1.000 13.54270 ? 237  ILE A N   1 
ATOM   1921 C  CA  . ILE A 1 237 ? -9.65878  30.43607 -9.26881  1.000 15.46566 ? 237  ILE A CA  1 
ATOM   1922 C  C   . ILE A 1 237 ? -9.02157  31.62290 -9.97876  1.000 13.02361 ? 237  ILE A C   1 
ATOM   1923 O  O   . ILE A 1 237 ? -9.70357  32.54439 -10.44672 1.000 14.01083 ? 237  ILE A O   1 
ATOM   1924 C  CB  . ILE A 1 237 ? -9.27918  29.11442 -9.96631  1.000 11.98954 ? 237  ILE A CB  1 
ATOM   1925 C  CG1 . ILE A 1 237 ? -9.72179  29.11893 -11.43279 1.000 13.14399 ? 237  ILE A CG1 1 
ATOM   1926 C  CG2 . ILE A 1 237 ? -9.86053  27.92492 -9.20947  1.000 16.91578 ? 237  ILE A CG2 1 
ATOM   1927 C  CD1 . ILE A 1 237 ? -9.39588  27.82144 -12.16896 1.000 14.06733 ? 237  ILE A CD1 1 
ATOM   1928 N  N   . GLN A 1 238 ? -7.70260  31.59954 -10.05475 1.000 12.77574 ? 238  GLN A N   1 
ATOM   1929 C  CA  . GLN A 1 238 ? -6.91155  32.66483 -10.63807 1.000 13.41560 ? 238  GLN A CA  1 
ATOM   1930 C  C   . GLN A 1 238 ? -6.16369  32.11458 -11.84201 1.000 14.64685 ? 238  GLN A C   1 
ATOM   1931 O  O   . GLN A 1 238 ? -6.25095  30.92557 -12.16646 1.000 14.00961 ? 238  GLN A O   1 
ATOM   1932 C  CB  . GLN A 1 238 ? -5.95828  33.25407 -9.59257  1.000 12.17768 ? 238  GLN A CB  1 
ATOM   1933 C  CG  . GLN A 1 238 ? -6.69036  33.88541 -8.40556  1.000 16.92068 ? 238  GLN A CG  1 
ATOM   1934 C  CD  . GLN A 1 238 ? -5.79708  34.04391 -7.18386  1.000 18.31670 ? 238  GLN A CD  1 
ATOM   1935 O  OE1 . GLN A 1 238 ? -4.57630  34.15430 -7.29992  1.000 17.61867 ? 238  GLN A OE1 1 
ATOM   1936 N  NE2 . GLN A 1 238 ? -6.40346  34.03194 -6.01015  1.000 23.74029 ? 238  GLN A NE2 1 
ATOM   1937 N  N   . ILE A 1 239 ? -5.42393  32.99994 -12.51375 1.000 15.81492 ? 239  ILE A N   1 
ATOM   1938 C  CA  . ILE A 1 239 ? -4.65209  32.56599 -13.67256 1.000 17.77013 ? 239  ILE A CA  1 
ATOM   1939 C  C   . ILE A 1 239 ? -3.54995  31.60389 -13.24990 1.000 15.03637 ? 239  ILE A C   1 
ATOM   1940 O  O   . ILE A 1 239 ? -3.25073  30.64212 -13.96510 1.000 17.75943 ? 239  ILE A O   1 
ATOM   1941 C  CB  . ILE A 1 239 ? -4.10825  33.79834 -14.42819 1.000 19.00347 ? 239  ILE A CB  1 
ATOM   1942 C  CG1 . ILE A 1 239 ? -5.25763  34.52481 -15.13367 1.000 18.29381 ? 239  ILE A CG1 1 
ATOM   1943 C  CG2 . ILE A 1 239 ? -2.99838  33.41234 -15.42639 1.000 18.56166 ? 239  ILE A CG2 1 
ATOM   1944 C  CD1 . ILE A 1 239 ? -4.90501  35.91212 -15.65462 1.000 18.24303 ? 239  ILE A CD1 1 
ATOM   1945 N  N   . GLY A 1 240 ? -2.95716  31.80696 -12.07780 1.000 14.59566 ? 240  GLY A N   1 
ATOM   1946 C  CA  . GLY A 1 240 ? -1.79341  31.01610 -11.72284 1.000 18.35328 ? 240  GLY A CA  1 
ATOM   1947 C  C   . GLY A 1 240 ? -2.00095  30.07843 -10.55080 1.000 32.17497 ? 240  GLY A C   1 
ATOM   1948 O  O   . GLY A 1 240 ? -1.16025  29.21716 -10.27198 1.000 41.93540 ? 240  GLY A O   1 
ATOM   1949 N  N   . TRP A 1 241 ? -3.11004  30.24893 -9.84330  1.000 17.56429 ? 241  TRP A N   1 
ATOM   1950 C  CA  . TRP A 1 241 ? -3.39928  29.48168 -8.64944  1.000 21.03818 ? 241  TRP A CA  1 
ATOM   1951 C  C   . TRP A 1 241 ? -4.84297  29.01096 -8.71503  1.000 18.30964 ? 241  TRP A C   1 
ATOM   1952 O  O   . TRP A 1 241 ? -5.71617  29.77759 -9.13487  1.000 17.46529 ? 241  TRP A O   1 
ATOM   1953 C  CB  . TRP A 1 241 ? -3.19482  30.32558 -7.37938  1.000 22.67208 ? 241  TRP A CB  1 
ATOM   1954 C  CG  . TRP A 1 241 ? -3.79092  29.68139 -6.16456  1.000 23.31277 ? 241  TRP A CG  1 
ATOM   1955 C  CD1 . TRP A 1 241 ? -3.14141  28.90827 -5.25136  1.000 27.77246 ? 241  TRP A CD1 1 
ATOM   1956 C  CD2 . TRP A 1 241 ? -5.16656  29.73303 -5.74068  1.000 30.74582 ? 241  TRP A CD2 1 
ATOM   1957 N  NE1 . TRP A 1 241 ? -4.01903  28.47790 -4.28398  1.000 35.68291 ? 241  TRP A NE1 1 
ATOM   1958 C  CE2 . TRP A 1 241 ? -5.26780  28.96794 -4.56201  1.000 35.02242 ? 241  TRP A CE2 1 
ATOM   1959 C  CE3 . TRP A 1 241 ? -6.31713  30.35566 -6.24121  1.000 24.55398 ? 241  TRP A CE3 1 
ATOM   1960 C  CZ2 . TRP A 1 241 ? -6.47089  28.81114 -3.87371  1.000 33.78516 ? 241  TRP A CZ2 1 
ATOM   1961 C  CZ3 . TRP A 1 241 ? -7.51695  30.18169 -5.56559  1.000 33.70871 ? 241  TRP A CZ3 1 
ATOM   1962 C  CH2 . TRP A 1 241 ? -7.58052  29.42274 -4.39137  1.000 37.87836 ? 241  TRP A CH2 1 
ATOM   1963 N  N   . PRO A 1 242 ? -5.13525  27.76736 -8.29637  1.000 24.28881 ? 242  PRO A N   1 
ATOM   1964 C  CA  . PRO A 1 242 ? -4.17664  26.73490 -7.88847  1.000 22.70394 ? 242  PRO A CA  1 
ATOM   1965 C  C   . PRO A 1 242 ? -3.55988  26.04039 -9.09116  1.000 19.47819 ? 242  PRO A C   1 
ATOM   1966 O  O   . PRO A 1 242 ? -4.08510  26.15173 -10.19340 1.000 21.20752 ? 242  PRO A O   1 
ATOM   1967 C  CB  . PRO A 1 242 ? -5.03281  25.76401 -7.08861  1.000 20.94528 ? 242  PRO A CB  1 
ATOM   1968 C  CG  . PRO A 1 242 ? -6.37043  25.85831 -7.74078  1.000 26.02841 ? 242  PRO A CG  1 
ATOM   1969 C  CD  . PRO A 1 242 ? -6.52642  27.32249 -8.09532  1.000 19.20250 ? 242  PRO A CD  1 
ATOM   1970 N  N   . SER A 1 243 ? -2.45729  25.33210 -8.88476  1.000 16.06594 ? 243  SER A N   1 
ATOM   1971 C  CA  . SER A 1 243 ? -1.79918  24.65518 -9.99182  1.000 17.17711 ? 243  SER A CA  1 
ATOM   1972 C  C   . SER A 1 243 ? -2.67174  23.53055 -10.53524 1.000 17.23593 ? 243  SER A C   1 
ATOM   1973 O  O   . SER A 1 243 ? -3.48782  22.93886 -9.81758  1.000 15.72209 ? 243  SER A O   1 
ATOM   1974 C  CB  . SER A 1 243 ? -0.46007  24.08184 -9.54247  1.000 20.50332 ? 243  SER A CB  1 
ATOM   1975 O  OG  . SER A 1 243 ? -0.66961  22.99398 -8.65533  1.000 16.59394 ? 243  SER A OG  1 
ATOM   1976 N  N   . GLU A 1 244 ? -2.47805  23.21953 -11.82192 1.000 18.30928 ? 244  GLU A N   1 
ATOM   1977 C  CA  . GLU A 1 244 ? -3.20809  22.09954 -12.40456 1.000 20.75394 ? 244  GLU A CA  1 
ATOM   1978 C  C   . GLU A 1 244 ? -2.89055  20.79996 -11.67641 1.000 21.12451 ? 244  GLU A C   1 
ATOM   1979 O  O   . GLU A 1 244 ? -3.77690  19.95393 -11.50467 1.000 16.83403 ? 244  GLU A O   1 
ATOM   1980 C  CB  . GLU A 1 244 ? -2.90461  21.97557 -13.89770 1.000 19.99529 ? 244  GLU A CB  1 
ATOM   1981 C  CG  . GLU A 1 244 ? -3.56873  23.05073 -14.74938 1.000 21.40567 ? 244  GLU A CG  1 
ATOM   1982 C  CD  . GLU A 1 244 ? -2.66216  24.25922 -14.98262 1.000 25.70768 ? 244  GLU A CD  1 
ATOM   1983 O  OE1 . GLU A 1 244 ? -1.43001  24.08903 -14.96223 1.000 29.47749 ? 244  GLU A OE1 1 
ATOM   1984 O  OE2 . GLU A 1 244 ? -3.17315  25.38074 -15.18865 1.000 23.60984 ? 244  GLU A OE2 1 
ATOM   1985 N  N   . ALA A 1 245 ? -1.64537  20.64970 -11.20361 1.000 19.45517 ? 245  ALA A N   1 
ATOM   1986 C  CA  . ALA A 1 245 ? -1.26312  19.45606 -10.45557 1.000 19.61510 ? 245  ALA A CA  1 
ATOM   1987 C  C   . ALA A 1 245 ? -2.09743  19.30346 -9.19533  1.000 17.76957 ? 245  ALA A C   1 
ATOM   1988 O  O   . ALA A 1 245 ? -2.51505  18.19303 -8.85196  1.000 15.86859 ? 245  ALA A O   1 
ATOM   1989 C  CB  . ALA A 1 245 ? 0.22916   19.51368 -10.10391 1.000 20.77481 ? 245  ALA A CB  1 
ATOM   1990 N  N   . GLU A 1 246 ? -2.34423  20.40897 -8.48435  1.000 10.78759 ? 246  GLU A N   1 
ATOM   1991 C  CA  . GLU A 1 246 ? -3.09662  20.31880 -7.23929  1.000 16.69611 ? 246  GLU A CA  1 
ATOM   1992 C  C   . GLU A 1 246 ? -4.58641  20.10381 -7.49692  1.000 14.57242 ? 246  GLU A C   1 
ATOM   1993 O  O   . GLU A 1 246 ? -5.25570  19.41233 -6.72229  1.000 16.74229 ? 246  GLU A O   1 
ATOM   1994 C  CB  . GLU A 1 246 ? -2.85527  21.57175 -6.40332  1.000 15.03717 ? 246  GLU A CB  1 
ATOM   1995 C  CG  . GLU A 1 246 ? -1.47484  21.61433 -5.76538  1.000 23.54118 ? 246  GLU A CG  1 
ATOM   1996 C  CD  . GLU A 1 246 ? -1.24444  20.48178 -4.76975  1.000 24.43768 ? 246  GLU A CD  1 
ATOM   1997 O  OE1 . GLU A 1 246 ? -2.23010  19.95334 -4.20163  1.000 25.62987 ? 246  GLU A OE1 1 
ATOM   1998 O  OE2 . GLU A 1 246 ? -0.06456  20.12035 -4.54883  1.000 33.82771 ? 246  GLU A OE2 1 
ATOM   1999 N  N   . ILE A 1 247 ? -5.11193  20.67055 -8.58397  1.000 15.05787 ? 247  ILE A N   1 
ATOM   2000 C  CA  . ILE A 1 247 ? -6.47806  20.36775 -9.00076  1.000 13.79448 ? 247  ILE A CA  1 
ATOM   2001 C  C   . ILE A 1 247 ? -6.62844  18.87716 -9.27291  1.000 18.38197 ? 247  ILE A C   1 
ATOM   2002 O  O   . ILE A 1 247 ? -7.55908  18.22319 -8.78127  1.000 14.82462 ? 247  ILE A O   1 
ATOM   2003 C  CB  . ILE A 1 247 ? -6.84977  21.20340 -10.23445 1.000 12.21417 ? 247  ILE A CB  1 
ATOM   2004 C  CG1 . ILE A 1 247 ? -6.88628  22.69456 -9.86552  1.000 13.39303 ? 247  ILE A CG1 1 
ATOM   2005 C  CG2 . ILE A 1 247 ? -8.18845  20.73569 -10.80947 1.000 14.55021 ? 247  ILE A CG2 1 
ATOM   2006 C  CD1 . ILE A 1 247 ? -7.24299  23.58673 -11.03970 1.000 16.51057 ? 247  ILE A CD1 1 
ATOM   2007 N  N   . GLU A 1 248 ? -5.71076  18.32209 -10.06872 1.000 15.30933 ? 248  GLU A N   1 
ATOM   2008 C  CA  . GLU A 1 248 ? -5.75094  16.90195 -10.39536 1.000 13.28694 ? 248  GLU A CA  1 
ATOM   2009 C  C   . GLU A 1 248 ? -5.69264  16.04001 -9.13750  1.000 16.41039 ? 248  GLU A C   1 
ATOM   2010 O  O   . GLU A 1 248 ? -6.45477  15.07575 -8.99458  1.000 16.72206 ? 248  GLU A O   1 
ATOM   2011 C  CB  . GLU A 1 248 ? -4.59087  16.56789 -11.34088 1.000 16.67516 ? 248  GLU A CB  1 
ATOM   2012 C  CG  . GLU A 1 248 ? -4.43032  15.08183 -11.61517 1.000 21.48413 ? 248  GLU A CG  1 
ATOM   2013 C  CD  . GLU A 1 248 ? -3.58531  14.82007 -12.84283 1.000 22.10326 ? 248  GLU A CD  1 
ATOM   2014 O  OE1 . GLU A 1 248 ? -2.75236  15.68858 -13.18130 1.000 26.47488 ? 248  GLU A OE1 1 
ATOM   2015 O  OE2 . GLU A 1 248 ? -3.76516  13.75807 -13.47229 1.000 26.47367 ? 248  GLU A OE2 1 
ATOM   2016 N  N   . LYS A 1 249 ? -4.78696  16.37696 -8.21146  1.000 18.19083 ? 249  LYS A N   1 
ATOM   2017 C  CA  . LYS A 1 249 ? -4.67025  15.62167 -6.96608  1.000 19.88345 ? 249  LYS A CA  1 
ATOM   2018 C  C   . LYS A 1 249 ? -5.97655  15.66219 -6.18445  1.000 18.36466 ? 249  LYS A C   1 
ATOM   2019 O  O   . LYS A 1 249 ? -6.40443  14.65175 -5.61092  1.000 17.86699 ? 249  LYS A O   1 
ATOM   2020 C  CB  . LYS A 1 249 ? -3.51637  16.18699 -6.13056  1.000 15.20124 ? 249  LYS A CB  1 
ATOM   2021 C  CG  . LYS A 1 249 ? -3.31395  15.54797 -4.76500  1.000 20.05022 ? 249  LYS A CG  1 
ATOM   2022 C  CD  . LYS A 1 249 ? -2.04420  16.12180 -4.10477  1.000 26.37046 ? 249  LYS A CD  1 
ATOM   2023 C  CE  . LYS A 1 249 ? -1.80867  15.53285 -2.71346  1.000 32.67531 ? 249  LYS A CE  1 
ATOM   2024 N  NZ  . LYS A 1 249 ? -0.41736  15.78752 -2.22407  1.000 38.36358 ? 249  LYS A NZ  1 
ATOM   2025 N  N   . THR A 1 250 ? -6.63436  16.82151 -6.17578  1.000 17.91375 ? 250  THR A N   1 
ATOM   2026 C  CA  . THR A 1 250 ? -7.90753  16.96416 -5.47465  1.000 15.06321 ? 250  THR A CA  1 
ATOM   2027 C  C   . THR A 1 250 ? -8.98716  16.09735 -6.10754  1.000 15.72894 ? 250  THR A C   1 
ATOM   2028 O  O   . THR A 1 250 ? -9.66302  15.32477 -5.41875  1.000 17.84558 ? 250  THR A O   1 
ATOM   2029 C  CB  . THR A 1 250 ? -8.33303  18.43414 -5.48514  1.000 15.77621 ? 250  THR A CB  1 
ATOM   2030 O  OG1 . THR A 1 250 ? -7.24768  19.23934 -5.01132  1.000 14.58353 ? 250  THR A OG1 1 
ATOM   2031 C  CG2 . THR A 1 250 ? -9.55617  18.64521 -4.59608  1.000 14.44991 ? 250  THR A CG2 1 
ATOM   2032 N  N   . ILE A 1 251 ? -9.17884  16.23648 -7.42419  1.000 14.90330 ? 251  ILE A N   1 
ATOM   2033 C  CA  . ILE A 1 251 ? -10.20761 15.47229 -8.12372  1.000 18.12120 ? 251  ILE A CA  1 
ATOM   2034 C  C   . ILE A 1 251 ? -9.99448  13.97953 -7.90719  1.000 20.04340 ? 251  ILE A C   1 
ATOM   2035 O  O   . ILE A 1 251 ? -10.94220 13.22755 -7.64002  1.000 17.89514 ? 251  ILE A O   1 
ATOM   2036 C  CB  . ILE A 1 251 ? -10.21471 15.83208 -9.62431  1.000 16.95899 ? 251  ILE A CB  1 
ATOM   2037 C  CG1 . ILE A 1 251 ? -10.61021 17.29762 -9.83637  1.000 17.33461 ? 251  ILE A CG1 1 
ATOM   2038 C  CG2 . ILE A 1 251 ? -11.17085 14.93412 -10.39202 1.000 18.62873 ? 251  ILE A CG2 1 
ATOM   2039 C  CD1 . ILE A 1 251 ? -12.03982 17.57434 -9.45160  1.000 20.21145 ? 251  ILE A CD1 1 
ATOM   2040 N  N   . ASN A 1 252 ? -8.74687  13.52907 -8.01002  1.000 16.85082 ? 252  ASN A N   1 
ATOM   2041 C  CA  . ASN A 1 252 ? -8.46530  12.10739 -7.86208  1.000 19.43217 ? 252  ASN A CA  1 
ATOM   2042 C  C   . ASN A 1 252 ? -8.75632  11.63036 -6.44718  1.000 17.37170 ? 252  ASN A C   1 
ATOM   2043 O  O   . ASN A 1 252 ? -9.28115  10.53119 -6.24745  1.000 23.01488 ? 252  ASN A O   1 
ATOM   2044 C  CB  . ASN A 1 252 ? -7.00843  11.84007 -8.22994  1.000 19.72085 ? 252  ASN A CB  1 
ATOM   2045 C  CG  . ASN A 1 252 ? -6.80507  11.77811 -9.71595  1.000 17.48951 ? 252  ASN A CG  1 
ATOM   2046 O  OD1 . ASN A 1 252 ? -7.75075  11.56819 -10.46070 1.000 20.05734 ? 252  ASN A OD1 1 
ATOM   2047 N  ND2 . ASN A 1 252 ? -5.57116  11.94313 -10.15838 1.000 17.51577 ? 252  ASN A ND2 1 
ATOM   2048 N  N   . MET A 1 253 ? -8.41462  12.45196 -5.45935  1.000 18.57988 ? 253  MET A N   1 
ATOM   2049 C  CA  . MET A 1 253 ? -8.58452  12.08540 -4.06044  1.000 20.26067 ? 253  MET A CA  1 
ATOM   2050 C  C   . MET A 1 253 ? -10.04521 11.80975 -3.73279  1.000 23.83535 ? 253  MET A C   1 
ATOM   2051 O  O   . MET A 1 253 ? -10.36717 10.83705 -3.03463  1.000 19.45588 ? 253  MET A O   1 
ATOM   2052 C  CB  . MET A 1 253 ? -8.03395  13.21507 -3.19955  1.000 22.62354 ? 253  MET A CB  1 
ATOM   2053 C  CG  . MET A 1 253 ? -8.03880  12.97058 -1.73403  1.000 28.49728 ? 253  MET A CG  1 
ATOM   2054 S  SD  . MET A 1 253 ? -7.49154  14.48757 -0.96101  1.000 31.12463 ? 253  MET A SD  1 
ATOM   2055 C  CE  . MET A 1 253 ? -5.89091  14.71474 -1.73151  1.000 23.32321 ? 253  MET A CE  1 
ATOM   2056 N  N   . PHE A 1 254 ? -10.95185 12.64381 -4.24049  1.000 22.64498 ? 254  PHE A N   1 
ATOM   2057 C  CA  . PHE A 1 254 ? -12.36308 12.41481 -3.95221  1.000 19.88454 ? 254  PHE A CA  1 
ATOM   2058 C  C   . PHE A 1 254 ? -12.93999 11.32067 -4.84040  1.000 18.99856 ? 254  PHE A C   1 
ATOM   2059 O  O   . PHE A 1 254 ? -13.78287 10.53578 -4.38996  1.000 21.88167 ? 254  PHE A O   1 
ATOM   2060 C  CB  . PHE A 1 254 ? -13.14521 13.71885 -4.08840  1.000 14.64230 ? 254  PHE A CB  1 
ATOM   2061 C  CG  . PHE A 1 254 ? -12.82009 14.71613 -3.02198  1.000 16.15029 ? 254  PHE A CG  1 
ATOM   2062 C  CD1 . PHE A 1 254 ? -13.30154 14.55072 -1.72582  1.000 18.81704 ? 254  PHE A CD1 1 
ATOM   2063 C  CD2 . PHE A 1 254 ? -12.01520 15.81412 -3.30553  1.000 17.38981 ? 254  PHE A CD2 1 
ATOM   2064 C  CE1 . PHE A 1 254 ? -12.99143 15.46844 -0.72219  1.000 15.92892 ? 254  PHE A CE1 1 
ATOM   2065 C  CE2 . PHE A 1 254 ? -11.71005 16.74193 -2.31921  1.000 17.94572 ? 254  PHE A CE2 1 
ATOM   2066 C  CZ  . PHE A 1 254 ? -12.19534 16.56443 -1.01977  1.000 16.39897 ? 254  PHE A CZ  1 
ATOM   2067 N  N   . ALA A 1 255 ? -12.49177 11.23555 -6.09331  1.000 18.07944 ? 255  ALA A N   1 
ATOM   2068 C  CA  . ALA A 1 255 ? -12.92026 10.12621 -6.93718  1.000 19.47750 ? 255  ALA A CA  1 
ATOM   2069 C  C   . ALA A 1 255 ? -12.57667 8.78385  -6.30124  1.000 23.74429 ? 255  ALA A C   1 
ATOM   2070 O  O   . ALA A 1 255 ? -13.31970 7.80863  -6.46548  1.000 24.10876 ? 255  ALA A O   1 
ATOM   2071 C  CB  . ALA A 1 255 ? -12.27903 10.23632 -8.31912  1.000 19.68887 ? 255  ALA A CB  1 
ATOM   2072 N  N   . ALA A 1 256 ? -11.46058 8.71776  -5.56975  1.000 21.63602 ? 256  ALA A N   1 
ATOM   2073 C  CA  . ALA A 1 256 ? -11.07133 7.46909  -4.91944  1.000 28.77887 ? 256  ALA A CA  1 
ATOM   2074 C  C   . ALA A 1 256 ? -12.08902 7.03591  -3.87362  1.000 27.74880 ? 256  ALA A C   1 
ATOM   2075 O  O   . ALA A 1 256 ? -12.23632 5.83610  -3.61511  1.000 28.99112 ? 256  ALA A O   1 
ATOM   2076 C  CB  . ALA A 1 256 ? -9.69006  7.61480  -4.27879  1.000 26.91880 ? 256  ALA A CB  1 
ATOM   2077 N  N   . LEU A 1 257 ? -12.79360 7.98799  -3.25881  1.000 23.22455 ? 257  LEU A N   1 
ATOM   2078 C  CA  . LEU A 1 257 ? -13.84181 7.67296  -2.29442  1.000 23.24564 ? 257  LEU A CA  1 
ATOM   2079 C  C   . LEU A 1 257 ? -15.13232 7.19749  -2.93935  1.000 28.12892 ? 257  LEU A C   1 
ATOM   2080 O  O   . LEU A 1 257 ? -16.09133 6.90468  -2.21582  1.000 28.26324 ? 257  LEU A O   1 
ATOM   2081 C  CB  . LEU A 1 257 ? -14.15404 8.89018  -1.43372  1.000 23.02934 ? 257  LEU A CB  1 
ATOM   2082 C  CG  . LEU A 1 257 ? -13.08568 9.26879  -0.41989  1.000 25.54371 ? 257  LEU A CG  1 
ATOM   2083 C  CD1 . LEU A 1 257 ? -13.59196 10.40334 0.46060   1.000 26.40366 ? 257  LEU A CD1 1 
ATOM   2084 C  CD2 . LEU A 1 257 ? -12.70880 8.05714  0.41043   1.000 29.45660 ? 257  LEU A CD2 1 
ATOM   2085 N  N   . GLY A 1 258 ? -15.18784 7.11784  -4.26566  1.000 21.73210 ? 258  GLY A N   1 
ATOM   2086 C  CA  . GLY A 1 258 ? -16.43042 6.81092  -4.93938  1.000 20.31345 ? 258  GLY A CA  1 
ATOM   2087 C  C   . GLY A 1 258 ? -17.32433 8.00629  -5.17569  1.000 25.44183 ? 258  GLY A C   1 
ATOM   2088 O  O   . GLY A 1 258 ? -18.51770 7.83589  -5.44742  1.000 24.48834 ? 258  GLY A O   1 
ATOM   2089 N  N   . LEU A 1 259 ? -16.78633 9.21616  -5.09258  1.000 17.40595 ? 259  LEU A N   1 
ATOM   2090 C  CA  . LEU A 1 259 ? -17.57949 10.42588 -5.24118  1.000 17.09701 ? 259  LEU A CA  1 
ATOM   2091 C  C   . LEU A 1 259 ? -17.48632 10.95691 -6.66604  1.000 17.48379 ? 259  LEU A C   1 
ATOM   2092 O  O   . LEU A 1 259 ? -16.42085 10.91405 -7.28766  1.000 17.92863 ? 259  LEU A O   1 
ATOM   2093 C  CB  . LEU A 1 259 ? -17.10884 11.49547 -4.25851  1.000 15.70548 ? 259  LEU A CB  1 
ATOM   2094 C  CG  . LEU A 1 259 ? -17.35600 11.19006 -2.78112  1.000 21.29794 ? 259  LEU A CG  1 
ATOM   2095 C  CD1 . LEU A 1 259 ? -16.41658 12.03455 -1.93950  1.000 20.90576 ? 259  LEU A CD1 1 
ATOM   2096 C  CD2 . LEU A 1 259 ? -18.81777 11.47075 -2.42739  1.000 19.06969 ? 259  LEU A CD2 1 
ATOM   2097 N  N   . ASP A 1 260 ? -18.61584 11.43321 -7.18657  1.000 18.44388 ? 260  ASP A N   1 
ATOM   2098 C  CA  . ASP A 1 260 ? -18.59286 12.26007 -8.38388  1.000 15.25547 ? 260  ASP A CA  1 
ATOM   2099 C  C   . ASP A 1 260 ? -17.95628 13.60204 -8.04162  1.000 12.42334 ? 260  ASP A C   1 
ATOM   2100 O  O   . ASP A 1 260 ? -17.93911 14.02659 -6.88143  1.000 12.74967 ? 260  ASP A O   1 
ATOM   2101 C  CB  . ASP A 1 260 ? -20.01790 12.43964 -8.92201  1.000 15.61647 ? 260  ASP A CB  1 
ATOM   2102 C  CG  . ASP A 1 260 ? -20.07086 13.22549 -10.21669 1.000 16.95610 ? 260  ASP A CG  1 
ATOM   2103 O  OD1 . ASP A 1 260 ? -19.23143 12.98715 -11.10981 1.000 17.94205 ? 260  ASP A OD1 1 
ATOM   2104 O  OD2 . ASP A 1 260 ? -20.97748 14.07098 -10.34367 1.000 17.20668 ? 260  ASP A OD2 1 
ATOM   2105 N  N   . ASN A 1 261 ? -17.39119 14.25617 -9.05383  1.000 12.11504 ? 261  ASN A N   1 
ATOM   2106 C  CA  . ASN A 1 261 ? -16.90283 15.62764 -8.93637  1.000 10.77652 ? 261  ASN A CA  1 
ATOM   2107 C  C   . ASN A 1 261 ? -17.64572 16.50735 -9.93074  1.000 13.39570 ? 261  ASN A C   1 
ATOM   2108 O  O   . ASN A 1 261 ? -17.80351 16.13498 -11.09975 1.000 12.92975 ? 261  ASN A O   1 
ATOM   2109 C  CB  . ASN A 1 261 ? -15.39311 15.72116 -9.20328  1.000 11.64197 ? 261  ASN A CB  1 
ATOM   2110 C  CG  . ASN A 1 261 ? -14.57577 14.93839 -8.19677  1.000 16.46500 ? 261  ASN A CG  1 
ATOM   2111 O  OD1 . ASN A 1 261 ? -14.24284 15.44409 -7.11977  1.000 15.41205 ? 261  ASN A OD1 1 
ATOM   2112 N  ND2 . ASN A 1 261 ? -14.24763 13.69549 -8.54045  1.000 15.35348 ? 261  ASN A ND2 1 
ATOM   2113 N  N   . GLN A 1 262 ? -18.10796 17.66555 -9.47364  1.000 12.95032 ? 262  GLN A N   1 
ATOM   2114 C  CA  . GLN A 1 262 ? -18.62383 18.67211 -10.38313 1.000 11.65750 ? 262  GLN A CA  1 
ATOM   2115 C  C   . GLN A 1 262 ? -17.89138 19.97379 -10.11599 1.000 9.70836  ? 262  GLN A C   1 
ATOM   2116 O  O   . GLN A 1 262 ? -17.57816 20.30271 -8.96888  1.000 12.11763 ? 262  GLN A O   1 
ATOM   2117 C  CB  . GLN A 1 262 ? -20.14611 18.85401 -10.25216 1.000 9.67742  ? 262  GLN A CB  1 
ATOM   2118 C  CG  . GLN A 1 262 ? -20.93714 17.56917 -10.57886 1.000 11.57384 ? 262  GLN A CG  1 
ATOM   2119 C  CD  . GLN A 1 262 ? -22.43118 17.78115 -10.65680 1.000 12.83133 ? 262  GLN A CD  1 
ATOM   2120 O  OE1 . GLN A 1 262 ? -23.01809 18.45171 -9.80452  1.000 13.48191 ? 262  GLN A OE1 1 
ATOM   2121 N  NE2 . GLN A 1 262 ? -23.06839 17.19241 -11.67611 1.000 14.36795 ? 262  GLN A NE2 1 
ATOM   2122 N  N   . ILE A 1 263 ? -17.55056 20.65866 -11.19776 1.000 10.31861 ? 263  ILE A N   1 
ATOM   2123 C  CA  . ILE A 1 263 ? -16.99712 22.00509 -11.15275 1.000 11.84269 ? 263  ILE A CA  1 
ATOM   2124 C  C   . ILE A 1 263 ? -18.20418 22.93523 -11.17171 1.000 9.59815  ? 263  ILE A C   1 
ATOM   2125 O  O   . ILE A 1 263 ? -18.90903 23.00749 -12.17960 1.000 11.61404 ? 263  ILE A O   1 
ATOM   2126 C  CB  . ILE A 1 263 ? -16.06168 22.25863 -12.34408 1.000 10.53980 ? 263  ILE A CB  1 
ATOM   2127 C  CG1 . ILE A 1 263 ? -15.03828 21.11556 -12.50986 1.000 15.02463 ? 263  ILE A CG1 1 
ATOM   2128 C  CG2 . ILE A 1 263 ? -15.37431 23.64531 -12.25234 1.000 10.97081 ? 263  ILE A CG2 1 
ATOM   2129 C  CD1 . ILE A 1 263 ? -14.21453 20.79826 -11.28497 1.000 17.04253 ? 263  ILE A CD1 1 
ATOM   2130 N  N   . THR A 1 264 ? -18.49193 23.59794 -10.04889 1.000 10.65728 ? 264  THR A N   1 
ATOM   2131 C  CA  . THR A 1 264 ? -19.82365 24.18654 -9.87176  1.000 10.74767 ? 264  THR A CA  1 
ATOM   2132 C  C   . THR A 1 264 ? -19.88351 25.69572 -10.05856 1.000 11.10716 ? 264  THR A C   1 
ATOM   2133 O  O   . THR A 1 264 ? -20.97805 26.21920 -10.26362 1.000 10.59286 ? 264  THR A O   1 
ATOM   2134 C  CB  . THR A 1 264 ? -20.38756 23.86302 -8.48063  1.000 11.20071 ? 264  THR A CB  1 
ATOM   2135 O  OG1 . THR A 1 264 ? -19.51126 24.39560 -7.48045  1.000 13.32716 ? 264  THR A OG1 1 
ATOM   2136 C  CG2 . THR A 1 264 ? -20.51552 22.34739 -8.29011  1.000 12.23496 ? 264  THR A CG2 1 
ATOM   2137 N  N   . GLY A 1 265 ? -18.76501 26.41107 -9.97510  1.000 8.76620  ? 265  GLY A N   1 
ATOM   2138 C  CA  . GLY A 1 265 ? -18.81318 27.86304 -10.04735 1.000 9.77147  ? 265  GLY A CA  1 
ATOM   2139 C  C   . GLY A 1 265 ? -17.59136 28.45613 -10.72194 1.000 9.24622  ? 265  GLY A C   1 
ATOM   2140 O  O   . GLY A 1 265 ? -17.09510 29.50900 -10.31486 1.000 9.90208  ? 265  GLY A O   1 
ATOM   2141 N  N   . LEU A 1 266 ? -17.09672 27.78131 -11.75318 1.000 9.09978  ? 266  LEU A N   1 
ATOM   2142 C  CA  . LEU A 1 266 ? -15.83392 28.17219 -12.37594 1.000 10.90988 ? 266  LEU A CA  1 
ATOM   2143 C  C   . LEU A 1 266 ? -15.84245 29.63103 -12.82762 1.000 10.70584 ? 266  LEU A C   1 
ATOM   2144 O  O   . LEU A 1 266 ? -16.75288 30.08032 -13.53491 1.000 9.59387  ? 266  LEU A O   1 
ATOM   2145 C  CB  . LEU A 1 266 ? -15.54509 27.25693 -13.56761 1.000 8.80465  ? 266  LEU A CB  1 
ATOM   2146 C  CG  . LEU A 1 266 ? -14.28372 27.52743 -14.39508 1.000 11.54235 ? 266  LEU A CG  1 
ATOM   2147 C  CD1 . LEU A 1 266 ? -13.05262 27.39309 -13.53121 1.000 7.84185  ? 266  LEU A CD1 1 
ATOM   2148 C  CD2 . LEU A 1 266 ? -14.23742 26.54326 -15.57231 1.000 10.24745 ? 266  LEU A CD2 1 
ATOM   2149 N  N   . ASP A 1 267 ? -14.82969 30.37711 -12.39061 1.000 9.36880  ? 267  ASP A N   1 
ATOM   2150 C  CA  . ASP A 1 267 ? -14.43892 31.62136 -13.03798 1.000 10.86816 ? 267  ASP A CA  1 
ATOM   2151 C  C   . ASP A 1 267 ? -12.92964 31.76821 -12.88171 1.000 10.56921 ? 267  ASP A C   1 
ATOM   2152 O  O   . ASP A 1 267 ? -12.36258 31.32532 -11.88151 1.000 10.89688 ? 267  ASP A O   1 
ATOM   2153 C  CB  . ASP A 1 267 ? -15.19026 32.85120 -12.47354 1.000 12.07895 ? 267  ASP A CB  1 
ATOM   2154 C  CG  . ASP A 1 267 ? -15.44118 32.77687 -10.95711 1.000 11.68057 ? 267  ASP A CG  1 
ATOM   2155 O  OD1 . ASP A 1 267 ? -14.57927 32.28140 -10.21442 1.000 13.73719 ? 267  ASP A OD1 1 
ATOM   2156 O  OD2 . ASP A 1 267 ? -16.51482 33.23540 -10.50382 1.000 13.71137 ? 267  ASP A OD2 1 
ATOM   2157 N  N   . VAL A 1 268 ? -12.27192 32.34354 -13.88728 1.000 9.88712  ? 268  VAL A N   1 
ATOM   2158 C  CA  . VAL A 1 268 ? -10.82696 32.54060 -13.83666 1.000 10.61823 ? 268  VAL A CA  1 
ATOM   2159 C  C   . VAL A 1 268 ? -10.60151 34.04257 -13.70921 1.000 10.92986 ? 268  VAL A C   1 
ATOM   2160 O  O   . VAL A 1 268 ? -10.59127 34.77782 -14.70482 1.000 10.15625 ? 268  VAL A O   1 
ATOM   2161 C  CB  . VAL A 1 268 ? -10.11539 31.94303 -15.05772 1.000 10.73381 ? 268  VAL A CB  1 
ATOM   2162 C  CG1 . VAL A 1 268 ? -8.59046  32.21832 -14.99907 1.000 10.56786 ? 268  VAL A CG1 1 
ATOM   2163 C  CG2 . VAL A 1 268 ? -10.36682 30.44883 -15.13100 1.000 9.45377  ? 268  VAL A CG2 1 
ATOM   2164 N  N   . SER A 1 269 ? -10.44402 34.50752 -12.47242 1.000 12.08005 ? 269  SER A N   1 
ATOM   2165 C  CA  . SER A 1 269 ? -10.24170 35.92876 -12.22381 1.000 12.52660 ? 269  SER A CA  1 
ATOM   2166 C  C   . SER A 1 269 ? -8.98433  36.43490 -12.92159 1.000 13.61310 ? 269  SER A C   1 
ATOM   2167 O  O   . SER A 1 269 ? -8.00249  35.70694 -13.09961 1.000 14.53166 ? 269  SER A O   1 
ATOM   2168 C  CB  . SER A 1 269 ? -10.12976 36.20162 -10.72289 1.000 13.29988 ? 269  SER A CB  1 
ATOM   2169 O  OG  . SER A 1 269 ? -9.83851  37.58051 -10.48543 1.000 13.90745 ? 269  SER A OG  1 
ATOM   2170 N  N   . MET A 1 270 ? -9.01724  37.70719 -13.31127 1.000 10.97049 ? 270  MET A N   1 
ATOM   2171 C  CA  . MET A 1 270 ? -7.82501  38.35961 -13.84192 1.000 13.15744 ? 270  MET A CA  1 
ATOM   2172 C  C   . MET A 1 270 ? -6.83437  38.72104 -12.75088 1.000 14.99230 ? 270  MET A C   1 
ATOM   2173 O  O   . MET A 1 270 ? -5.68903  39.07085 -13.06473 1.000 12.67238 ? 270  MET A O   1 
ATOM   2174 C  CB  . MET A 1 270 ? -8.21021  39.63182 -14.61376 1.000 13.32858 ? 270  MET A CB  1 
ATOM   2175 C  CG  . MET A 1 270 ? -8.82821  39.39745 -15.98681 1.000 10.57506 ? 270  MET A CG  1 
ATOM   2176 S  SD  . MET A 1 270 ? -7.81472  38.30450 -17.03133 1.000 16.06177 ? 270  MET A SD  1 
ATOM   2177 C  CE  . MET A 1 270 ? -8.61443  38.53065 -18.61541 1.000 12.66782 ? 270  MET A CE  1 
ATOM   2178 N  N   . TYR A 1 271 ? -7.23151  38.62391 -11.48328 1.000 13.64693 ? 271  TYR A N   1 
ATOM   2179 C  CA  . TYR A 1 271 ? -6.48466  39.22910 -10.39395 1.000 15.16304 ? 271  TYR A CA  1 
ATOM   2180 C  C   . TYR A 1 271 ? -6.00979  38.18319 -9.39675  1.000 15.95969 ? 271  TYR A C   1 
ATOM   2181 O  O   . TYR A 1 271 ? -6.31820  36.99255 -9.50113  1.000 18.07179 ? 271  TYR A O   1 
ATOM   2182 C  CB  . TYR A 1 271 ? -7.32898  40.29789 -9.69438  1.000 12.53370 ? 271  TYR A CB  1 
ATOM   2183 C  CG  . TYR A 1 271 ? -7.90164  41.25856 -10.69965 1.000 13.68992 ? 271  TYR A CG  1 
ATOM   2184 C  CD1 . TYR A 1 271 ? -7.06170  41.95831 -11.54631 1.000 13.95033 ? 271  TYR A CD1 1 
ATOM   2185 C  CD2 . TYR A 1 271 ? -9.27281  41.43444 -10.83648 1.000 13.43811 ? 271  TYR A CD2 1 
ATOM   2186 C  CE1 . TYR A 1 271 ? -7.55609  42.81698 -12.49645 1.000 14.07081 ? 271  TYR A CE1 1 
ATOM   2187 C  CE2 . TYR A 1 271 ? -9.78791  42.30022 -11.79331 1.000 11.44985 ? 271  TYR A CE2 1 
ATOM   2188 C  CZ  . TYR A 1 271 ? -8.91388  42.99440 -12.61754 1.000 11.58161 ? 271  TYR A CZ  1 
ATOM   2189 O  OH  . TYR A 1 271 ? -9.37254  43.86891 -13.57462 1.000 14.09239 ? 271  TYR A OH  1 
ATOM   2190 N  N   . GLY A 1 272 ? -5.20666  38.65606 -8.45400  1.000 15.76335 ? 272  GLY A N   1 
ATOM   2191 C  CA  . GLY A 1 272 ? -4.76607  37.87508 -7.32114  1.000 20.29269 ? 272  GLY A CA  1 
ATOM   2192 C  C   . GLY A 1 272 ? -5.73496  38.00748 -6.17179  1.000 20.08197 ? 272  GLY A C   1 
ATOM   2193 O  O   . GLY A 1 272 ? -6.92632  38.27192 -6.36118  1.000 19.28355 ? 272  GLY A O   1 
ATOM   2194 N  N   . TRP A 1 273 ? -5.21838  37.83151 -4.95048  1.000 18.11164 ? 273  TRP A N   1 
ATOM   2195 C  CA  . TRP A 1 273 ? -6.06215  37.91983 -3.75381  1.000 24.83496 ? 273  TRP A CA  1 
ATOM   2196 C  C   . TRP A 1 273 ? -5.26687  38.56110 -2.62287  1.000 25.43754 ? 273  TRP A C   1 
ATOM   2197 O  O   . TRP A 1 273 ? -4.15619  38.09602 -2.31440  1.000 23.71991 ? 273  TRP A O   1 
ATOM   2198 C  CB  . TRP A 1 273 ? -6.58785  36.55654 -3.31202  1.000 21.76563 ? 273  TRP A CB  1 
ATOM   2199 C  CG  . TRP A 1 273 ? -7.53624  36.68727 -2.17886  1.000 28.63986 ? 273  TRP A CG  1 
ATOM   2200 C  CD1 . TRP A 1 273 ? -7.25184  36.55491 -0.84632  1.000 29.93187 ? 273  TRP A CD1 1 
ATOM   2201 C  CD2 . TRP A 1 273 ? -8.93000  37.01389 -2.26235  1.000 28.13491 ? 273  TRP A CD2 1 
ATOM   2202 N  NE1 . TRP A 1 273 ? -8.38873  36.76359 -0.09999  1.000 39.81067 ? 273  TRP A NE1 1 
ATOM   2203 C  CE2 . TRP A 1 273 ? -9.43143  37.04627 -0.94456  1.000 32.61021 ? 273  TRP A CE2 1 
ATOM   2204 C  CE3 . TRP A 1 273 ? -9.80408  37.27089 -3.32324  1.000 24.02063 ? 273  TRP A CE3 1 
ATOM   2205 C  CZ2 . TRP A 1 273 ? -10.76634 37.32742 -0.66007  1.000 34.16454 ? 273  TRP A CZ2 1 
ATOM   2206 C  CZ3 . TRP A 1 273 ? -11.13849 37.55424 -3.03340  1.000 25.85110 ? 273  TRP A CZ3 1 
ATOM   2207 C  CH2 . TRP A 1 273 ? -11.60022 37.57818 -1.71768  1.000 27.48572 ? 273  TRP A CH2 1 
ATOM   2208 N  N   . PRO A 1 274 ? -5.77431  39.64353 -2.00698  1.000 26.19468 ? 274  PRO A N   1 
ATOM   2209 C  CA  . PRO A 1 274 ? -6.98002  40.39265 -2.38221  1.000 24.13093 ? 274  PRO A CA  1 
ATOM   2210 C  C   . PRO A 1 274 ? -6.78794  41.07748 -3.73432  1.000 21.50399 ? 274  PRO A C   1 
ATOM   2211 O  O   . PRO A 1 274 ? -5.68917  41.55606 -4.01081  1.000 20.38530 ? 274  PRO A O   1 
ATOM   2212 C  CB  . PRO A 1 274 ? -7.12090  41.43033 -1.25648  1.000 26.08569 ? 274  PRO A CB  1 
ATOM   2213 C  CG  . PRO A 1 274 ? -6.23419  40.94218 -0.15483  1.000 29.90680 ? 274  PRO A CG  1 
ATOM   2214 C  CD  . PRO A 1 274 ? -5.11579  40.23020 -0.82582  1.000 25.04803 ? 274  PRO A CD  1 
ATOM   2215 N  N   . PRO A 1 275 ? -7.82275  41.11701 -4.56868  1.000 15.60402 ? 275  PRO A N   1 
ATOM   2216 C  CA  . PRO A 1 275 ? -7.62788  41.60070 -5.94011  1.000 15.13334 ? 275  PRO A CA  1 
ATOM   2217 C  C   . PRO A 1 275 ? -7.34446  43.10003 -5.98178  1.000 18.01240 ? 275  PRO A C   1 
ATOM   2218 O  O   . PRO A 1 275 ? -7.88983  43.88017 -5.19584  1.000 15.40457 ? 275  PRO A O   1 
ATOM   2219 C  CB  . PRO A 1 275 ? -8.96406  41.27374 -6.63032  1.000 16.84518 ? 275  PRO A CB  1 
ATOM   2220 C  CG  . PRO A 1 275 ? -9.78112  40.49505 -5.61400  1.000 22.25638 ? 275  PRO A CG  1 
ATOM   2221 C  CD  . PRO A 1 275 ? -9.24299  40.86177 -4.27899  1.000 18.47470 ? 275  PRO A CD  1 
ATOM   2222 N  N   . ARG A 1 276 ? -6.48474  43.49323 -6.92237  1.000 15.52565 ? 276  ARG A N   1 
ATOM   2223 C  CA  . ARG A 1 276 ? -6.24773  44.89647 -7.26576  1.000 16.63788 ? 276  ARG A CA  1 
ATOM   2224 C  C   . ARG A 1 276 ? -6.69500  45.04717 -8.71571  1.000 12.21615 ? 276  ARG A C   1 
ATOM   2225 O  O   . ARG A 1 276 ? -5.94507  44.72969 -9.64634  1.000 14.78692 ? 276  ARG A O   1 
ATOM   2226 C  CB  . ARG A 1 276 ? -4.78920  45.28848 -7.06680  1.000 13.36765 ? 276  ARG A CB  1 
ATOM   2227 C  CG  . ARG A 1 276 ? -4.34327  45.15049 -5.61164  1.000 19.73050 ? 276  ARG A CG  1 
ATOM   2228 C  CD  . ARG A 1 276 ? -3.04792  45.90546 -5.31123  1.000 19.33420 ? 276  ARG A CD  1 
ATOM   2229 N  NE  . ARG A 1 276 ? -2.80178  45.96910 -3.86919  1.000 27.05193 ? 276  ARG A NE  1 
ATOM   2230 C  CZ  . ARG A 1 276 ? -1.82028  46.66800 -3.30405  1.000 23.33339 ? 276  ARG A CZ  1 
ATOM   2231 N  NH1 . ARG A 1 276 ? -0.98947  47.36417 -4.05746  1.000 24.71463 ? 276  ARG A NH1 1 
ATOM   2232 N  NH2 . ARG A 1 276 ? -1.68144  46.67519 -1.98523  1.000 23.03419 ? 276  ARG A NH2 1 
ATOM   2233 N  N   . ALA A 1 277 ? -7.91850  45.51765 -8.88776  1.000 13.67139 ? 277  ALA A N   1 
ATOM   2234 C  CA  . ALA A 1 277 ? -8.62620  45.45170 -10.15702 1.000 16.40519 ? 277  ALA A CA  1 
ATOM   2235 C  C   . ALA A 1 277 ? -8.39665  46.69169 -11.00410 1.000 18.53772 ? 277  ALA A C   1 
ATOM   2236 O  O   . ALA A 1 277 ? -8.14221  47.78575 -10.49235 1.000 16.65342 ? 277  ALA A O   1 
ATOM   2237 C  CB  . ALA A 1 277 ? -10.12671 45.29337 -9.91561  1.000 12.71402 ? 277  ALA A CB  1 
ATOM   2238 N  N   . TYR A 1 278 ? -8.50898  46.51208 -12.31543 1.000 16.16315 ? 278  TYR A N   1 
ATOM   2239 C  CA  . TYR A 1 278 ? -8.65935  47.65412 -13.19322 1.000 15.94086 ? 278  TYR A CA  1 
ATOM   2240 C  C   . TYR A 1 278 ? -10.05150 48.26093 -13.01214 1.000 16.08177 ? 278  TYR A C   1 
ATOM   2241 O  O   . TYR A 1 278 ? -10.99932 47.55996 -12.63602 1.000 16.30989 ? 278  TYR A O   1 
ATOM   2242 C  CB  . TYR A 1 278 ? -8.42320  47.23376 -14.64083 1.000 14.45989 ? 278  TYR A CB  1 
ATOM   2243 C  CG  . TYR A 1 278 ? -6.96671  46.91824 -14.90723 1.000 18.61221 ? 278  TYR A CG  1 
ATOM   2244 C  CD1 . TYR A 1 278 ? -6.02986  47.93618 -15.07381 1.000 19.86600 ? 278  TYR A CD1 1 
ATOM   2245 C  CD2 . TYR A 1 278 ? -6.52491  45.60456 -14.96738 1.000 12.53394 ? 278  TYR A CD2 1 
ATOM   2246 C  CE1 . TYR A 1 278 ? -4.69239  47.63854 -15.30658 1.000 16.89273 ? 278  TYR A CE1 1 
ATOM   2247 C  CE2 . TYR A 1 278 ? -5.21218  45.30203 -15.19462 1.000 18.56183 ? 278  TYR A CE2 1 
ATOM   2248 C  CZ  . TYR A 1 278 ? -4.29952  46.32161 -15.37056 1.000 16.61794 ? 278  TYR A CZ  1 
ATOM   2249 O  OH  . TYR A 1 278 ? -2.99934  45.98960 -15.59698 1.000 20.56810 ? 278  TYR A OH  1 
ATOM   2250 N  N   . PRO A 1 279 ? -10.20037 49.57379 -13.24264 1.000 19.01068 ? 279  PRO A N   1 
ATOM   2251 C  CA  . PRO A 1 279 ? -11.49318 50.20954 -12.95791 1.000 15.76807 ? 279  PRO A CA  1 
ATOM   2252 C  C   . PRO A 1 279 ? -12.57013 49.88643 -13.97758 1.000 13.66483 ? 279  PRO A C   1 
ATOM   2253 O  O   . PRO A 1 279 ? -13.75678 49.94913 -13.63500 1.000 16.15875 ? 279  PRO A O   1 
ATOM   2254 C  CB  . PRO A 1 279 ? -11.15319 51.71005 -12.95083 1.000 17.92540 ? 279  PRO A CB  1 
ATOM   2255 C  CG  . PRO A 1 279 ? -9.97332  51.82020 -13.85366 1.000 19.59899 ? 279  PRO A CG  1 
ATOM   2256 C  CD  . PRO A 1 279 ? -9.17912  50.55498 -13.66016 1.000 18.26493 ? 279  PRO A CD  1 
ATOM   2257 N  N   . THR A 1 280 ? -12.19324 49.55090 -15.21081 1.000 14.11713 ? 280  THR A N   1 
ATOM   2258 C  CA  . THR A 1 280 ? -13.12345 49.27497 -16.30071 1.000 17.13918 ? 280  THR A CA  1 
ATOM   2259 C  C   . THR A 1 280 ? -12.60295 48.09709 -17.10593 1.000 15.44505 ? 280  THR A C   1 
ATOM   2260 O  O   . THR A 1 280 ? -11.40734 47.79704 -17.09138 1.000 14.46184 ? 280  THR A O   1 
ATOM   2261 C  CB  . THR A 1 280 ? -13.27173 50.45475 -17.27130 1.000 17.60225 ? 280  THR A CB  1 
ATOM   2262 O  OG1 . THR A 1 280 ? -12.02145 50.63745 -17.94897 1.000 17.69464 ? 280  THR A OG1 1 
ATOM   2263 C  CG2 . THR A 1 280 ? -13.65312 51.73590 -16.54521 1.000 21.02725 ? 280  THR A CG2 1 
ATOM   2264 N  N   . TYR A 1 281 ? -13.51261 47.46206 -17.85773 1.000 15.88051 ? 281  TYR A N   1 
ATOM   2265 C  CA  . TYR A 1 281 ? -13.10300 46.39063 -18.76600 1.000 17.58280 ? 281  TYR A CA  1 
ATOM   2266 C  C   . TYR A 1 281 ? -12.09548 46.88556 -19.78850 1.000 15.32297 ? 281  TYR A C   1 
ATOM   2267 O  O   . TYR A 1 281 ? -11.15320 46.16880 -20.14631 1.000 13.08700 ? 281  TYR A O   1 
ATOM   2268 C  CB  . TYR A 1 281 ? -14.31700 45.81876 -19.49379 1.000 16.47535 ? 281  TYR A CB  1 
ATOM   2269 C  CG  . TYR A 1 281 ? -14.10469 44.44359 -20.07462 1.000 17.58138 ? 281  TYR A CG  1 
ATOM   2270 C  CD1 . TYR A 1 281 ? -13.60479 44.27438 -21.36110 1.000 15.08751 ? 281  TYR A CD1 1 
ATOM   2271 C  CD2 . TYR A 1 281 ? -14.43631 43.30037 -19.33731 1.000 15.59242 ? 281  TYR A CD2 1 
ATOM   2272 C  CE1 . TYR A 1 281 ? -13.42874 43.00107 -21.89567 1.000 15.03863 ? 281  TYR A CE1 1 
ATOM   2273 C  CE2 . TYR A 1 281 ? -14.25836 42.03560 -19.86008 1.000 12.70356 ? 281  TYR A CE2 1 
ATOM   2274 C  CZ  . TYR A 1 281 ? -13.75340 41.88712 -21.13715 1.000 17.21110 ? 281  TYR A CZ  1 
ATOM   2275 O  OH  . TYR A 1 281 ? -13.59821 40.61609 -21.66009 1.000 15.45068 ? 281  TYR A OH  1 
ATOM   2276 N  N   . ASP A 1 282 ? -12.30016 48.09577 -20.30393 1.000 14.31562 ? 282  ASP A N   1 
ATOM   2277 C  CA  . ASP A 1 282 ? -11.44605 48.57972 -21.37860 1.000 17.01176 ? 282  ASP A CA  1 
ATOM   2278 C  C   . ASP A 1 282 ? -10.00333 48.75678 -20.92836 1.000 18.35899 ? 282  ASP A C   1 
ATOM   2279 O  O   . ASP A 1 282 ? -9.09773  48.72468 -21.77081 1.000 18.04441 ? 282  ASP A O   1 
ATOM   2280 C  CB  . ASP A 1 282 ? -12.00974 49.89122 -21.93690 1.000 17.66386 ? 282  ASP A CB  1 
ATOM   2281 C  CG  . ASP A 1 282 ? -13.40094 49.70525 -22.55006 1.000 19.89949 ? 282  ASP A CG  1 
ATOM   2282 O  OD1 . ASP A 1 282 ? -13.67155 48.59806 -23.06488 1.000 23.63526 ? 282  ASP A OD1 1 
ATOM   2283 O  OD2 . ASP A 1 282 ? -14.21317 50.64903 -22.51093 1.000 30.98707 ? 282  ASP A OD2 1 
ATOM   2284 N  N   . ALA A 1 283 ? -9.76913  48.90460 -19.62128 1.000 14.14697 ? 283  ALA A N   1 
ATOM   2285 C  CA  . ALA A 1 283 ? -8.43127  49.14670 -19.09948 1.000 14.44884 ? 283  ALA A CA  1 
ATOM   2286 C  C   . ALA A 1 283 ? -7.61501  47.87295 -18.90694 1.000 15.47448 ? 283  ALA A C   1 
ATOM   2287 O  O   . ALA A 1 283 ? -6.40781  47.96656 -18.65108 1.000 14.97282 ? 283  ALA A O   1 
ATOM   2288 C  CB  . ALA A 1 283 ? -8.53314  49.90507 -17.77065 1.000 18.22821 ? 283  ALA A CB  1 
ATOM   2289 N  N   . ILE A 1 284 ? -8.22376  46.69403 -19.02158 1.000 15.59893 ? 284  ILE A N   1 
ATOM   2290 C  CA  . ILE A 1 284 ? -7.46044  45.45103 -18.83514 1.000 15.74871 ? 284  ILE A CA  1 
ATOM   2291 C  C   . ILE A 1 284 ? -6.56577  45.23073 -20.05136 1.000 16.58003 ? 284  ILE A C   1 
ATOM   2292 O  O   . ILE A 1 284 ? -7.06570  45.22745 -21.18870 1.000 17.56661 ? 284  ILE A O   1 
ATOM   2293 C  CB  . ILE A 1 284 ? -8.40536  44.25989 -18.61957 1.000 16.92543 ? 284  ILE A CB  1 
ATOM   2294 C  CG1 . ILE A 1 284 ? -9.34149  44.51238 -17.43532 1.000 13.75696 ? 284  ILE A CG1 1 
ATOM   2295 C  CG2 . ILE A 1 284 ? -7.59882  42.98451 -18.37158 1.000 14.90869 ? 284  ILE A CG2 1 
ATOM   2296 C  CD1 . ILE A 1 284 ? -10.49820 43.48829 -17.31227 1.000 16.01865 ? 284  ILE A CD1 1 
ATOM   2297 N  N   . PRO A 1 285 ? -5.25863  45.04877 -19.87420 1.000 17.60381 ? 285  PRO A N   1 
ATOM   2298 C  CA  . PRO A 1 285 ? -4.37094  44.89530 -21.03235 1.000 16.88959 ? 285  PRO A CA  1 
ATOM   2299 C  C   . PRO A 1 285 ? -4.62389  43.59537 -21.78211 1.000 21.20125 ? 285  PRO A C   1 
ATOM   2300 O  O   . PRO A 1 285 ? -4.98010  42.56694 -21.19701 1.000 16.11277 ? 285  PRO A O   1 
ATOM   2301 C  CB  . PRO A 1 285 ? -2.96742  44.90318 -20.41213 1.000 19.97810 ? 285  PRO A CB  1 
ATOM   2302 C  CG  . PRO A 1 285 ? -3.14145  45.41567 -19.02384 1.000 19.77027 ? 285  PRO A CG  1 
ATOM   2303 C  CD  . PRO A 1 285 ? -4.52010  45.05012 -18.60204 1.000 19.20942 ? 285  PRO A CD  1 
ATOM   2304 N  N   . LYS A 1 286 ? -4.40361  43.65195 -23.09903 1.000 17.86385 ? 286  LYS A N   1 
ATOM   2305 C  CA  . LYS A 1 286 ? -4.60955  42.48555 -23.95712 1.000 18.03310 ? 286  LYS A CA  1 
ATOM   2306 C  C   . LYS A 1 286 ? -3.84169  41.26677 -23.46463 1.000 18.05005 ? 286  LYS A C   1 
ATOM   2307 O  O   . LYS A 1 286 ? -4.30823  40.13612 -23.63232 1.000 19.31946 ? 286  LYS A O   1 
ATOM   2308 C  CB  . LYS A 1 286 ? -4.20056  42.80729 -25.40204 1.000 22.93522 ? 286  LYS A CB  1 
ATOM   2309 C  CG  . LYS A 1 286 ? -5.29411  43.52210 -26.19166 1.000 33.11892 ? 286  LYS A CG  1 
ATOM   2310 C  CD  . LYS A 1 286 ? -4.88920  43.84646 -27.61717 1.000 37.37493 ? 286  LYS A CD  1 
ATOM   2311 C  CE  . LYS A 1 286 ? -6.04347  43.56258 -28.57604 1.000 37.90235 ? 286  LYS A CE  1 
ATOM   2312 N  NZ  . LYS A 1 286 ? -5.99071  44.45011 -29.76525 1.000 40.24206 ? 286  LYS A NZ  1 
ATOM   2313 N  N   . GLN A 1 287 ? -2.66549  41.46697 -22.86486 1.000 18.84239 ? 287  GLN A N   1 
ATOM   2314 C  CA  . GLN A 1 287 ? -1.86960  40.32527 -22.42181 1.000 17.51879 ? 287  GLN A CA  1 
ATOM   2315 C  C   . GLN A 1 287 ? -2.59157  39.50597 -21.35950 1.000 17.64135 ? 287  GLN A C   1 
ATOM   2316 O  O   . GLN A 1 287 ? -2.40224  38.28635 -21.29432 1.000 17.91982 ? 287  GLN A O   1 
ATOM   2317 C  CB  . GLN A 1 287 ? -0.51452  40.78535 -21.88454 1.000 20.57937 ? 287  GLN A CB  1 
ATOM   2318 C  CG  . GLN A 1 287 ? 0.40732   39.61857 -21.52281 1.000 23.86622 ? 287  GLN A CG  1 
ATOM   2319 C  CD  . GLN A 1 287 ? 0.73468   38.76832 -22.73024 1.000 22.97960 ? 287  GLN A CD  1 
ATOM   2320 O  OE1 . GLN A 1 287 ? 1.02526   39.29576 -23.79899 1.000 25.97017 ? 287  GLN A OE1 1 
ATOM   2321 N  NE2 . GLN A 1 287 ? 0.67494   37.44648 -22.57482 1.000 22.99240 ? 287  GLN A NE2 1 
ATOM   2322 N  N   . LYS A 1 288 ? -3.40515  40.15076 -20.51385 1.000 18.24745 ? 288  LYS A N   1 
ATOM   2323 C  CA  . LYS A 1 288 ? -4.14803  39.40422 -19.50241 1.000 17.52154 ? 288  LYS A CA  1 
ATOM   2324 C  C   . LYS A 1 288 ? -5.04413  38.36043 -20.15238 1.000 15.13162 ? 288  LYS A C   1 
ATOM   2325 O  O   . LYS A 1 288 ? -5.22249  37.25921 -19.61930 1.000 14.79799 ? 288  LYS A O   1 
ATOM   2326 C  CB  . LYS A 1 288 ? -4.98937  40.34926 -18.63960 1.000 17.08239 ? 288  LYS A CB  1 
ATOM   2327 C  CG  . LYS A 1 288 ? -4.19872  41.26433 -17.72765 1.000 21.56898 ? 288  LYS A CG  1 
ATOM   2328 C  CD  . LYS A 1 288 ? -3.27998  40.48494 -16.82789 1.000 20.91776 ? 288  LYS A CD  1 
ATOM   2329 C  CE  . LYS A 1 288 ? -3.98395  40.01944 -15.57203 1.000 20.14146 ? 288  LYS A CE  1 
ATOM   2330 N  NZ  . LYS A 1 288 ? -3.08046  39.19642 -14.72348 1.000 22.39026 ? 288  LYS A NZ  1 
ATOM   2331 N  N   . PHE A 1 289 ? -5.62702  38.69616 -21.30390 1.000 15.04078 ? 289  PHE A N   1 
ATOM   2332 C  CA  . PHE A 1 289 ? -6.53667  37.76640 -21.95602 1.000 16.12471 ? 289  PHE A CA  1 
ATOM   2333 C  C   . PHE A 1 289 ? -5.77767  36.60840 -22.58717 1.000 15.39733 ? 289  PHE A C   1 
ATOM   2334 O  O   . PHE A 1 289 ? -6.28671  35.48249 -22.62690 1.000 14.10135 ? 289  PHE A O   1 
ATOM   2335 C  CB  . PHE A 1 289 ? -7.39832  38.52210 -22.97195 1.000 13.87350 ? 289  PHE A CB  1 
ATOM   2336 C  CG  . PHE A 1 289 ? -8.27046  39.57190 -22.33124 1.000 19.96024 ? 289  PHE A CG  1 
ATOM   2337 C  CD1 . PHE A 1 289 ? -9.53648  39.24703 -21.85648 1.000 18.56000 ? 289  PHE A CD1 1 
ATOM   2338 C  CD2 . PHE A 1 289 ? -7.80253  40.86577 -22.14654 1.000 16.39855 ? 289  PHE A CD2 1 
ATOM   2339 C  CE1 . PHE A 1 289 ? -10.34608 40.21068 -21.23733 1.000 19.55802 ? 289  PHE A CE1 1 
ATOM   2340 C  CE2 . PHE A 1 289 ? -8.59893  41.83444 -21.52551 1.000 20.64049 ? 289  PHE A CE2 1 
ATOM   2341 C  CZ  . PHE A 1 289 ? -9.87547  41.50512 -21.07313 1.000 15.86491 ? 289  PHE A CZ  1 
ATOM   2342 N  N   . LEU A 1 290 ? -4.55016  36.85292 -23.04847 1.000 15.83939 ? 290  LEU A N   1 
ATOM   2343 C  CA  . LEU A 1 290 ? -3.72523  35.75641 -23.53810 1.000 15.16491 ? 290  LEU A CA  1 
ATOM   2344 C  C   . LEU A 1 290 ? -3.30420  34.84559 -22.39313 1.000 15.86895 ? 290  LEU A C   1 
ATOM   2345 O  O   . LEU A 1 290 ? -3.35317  33.61913 -22.52495 1.000 15.21141 ? 290  LEU A O   1 
ATOM   2346 C  CB  . LEU A 1 290 ? -2.50095  36.30508 -24.27879 1.000 19.80538 ? 290  LEU A CB  1 
ATOM   2347 C  CG  . LEU A 1 290 ? -2.84977  37.18379 -25.48265 1.000 20.09113 ? 290  LEU A CG  1 
ATOM   2348 C  CD1 . LEU A 1 290 ? -1.58661  37.69898 -26.19260 1.000 22.98613 ? 290  LEU A CD1 1 
ATOM   2349 C  CD2 . LEU A 1 290 ? -3.74257  36.41476 -26.44751 1.000 24.77227 ? 290  LEU A CD2 1 
ATOM   2350 N  N   . ASP A 1 291 ? -2.89779  35.42819 -21.26021 1.000 11.98335 ? 291  ASP A N   1 
ATOM   2351 C  CA  . ASP A 1 291 ? -2.56403  34.62176 -20.08789 1.000 14.06351 ? 291  ASP A CA  1 
ATOM   2352 C  C   . ASP A 1 291 ? -3.76337  33.80105 -19.62883 1.000 19.42547 ? 291  ASP A C   1 
ATOM   2353 O  O   . ASP A 1 291 ? -3.62445  32.62944 -19.25504 1.000 15.02207 ? 291  ASP A O   1 
ATOM   2354 C  CB  . ASP A 1 291 ? -2.08804  35.52050 -18.94121 1.000 13.55473 ? 291  ASP A CB  1 
ATOM   2355 C  CG  . ASP A 1 291 ? -0.88044  36.37998 -19.32431 1.000 23.59315 ? 291  ASP A CG  1 
ATOM   2356 O  OD1 . ASP A 1 291 ? -0.16216  36.01212 -20.27523 1.000 18.89086 ? 291  ASP A OD1 1 
ATOM   2357 O  OD2 . ASP A 1 291 ? -0.65729  37.41522 -18.66780 1.000 21.03388 ? 291  ASP A OD2 1 
ATOM   2358 N  N   . GLN A 1 292 ? -4.95296  34.40496 -19.64339 1.000 14.05616 ? 292  GLN A N   1 
ATOM   2359 C  CA  . GLN A 1 292 ? -6.14520  33.67206 -19.22874 1.000 13.58578 ? 292  GLN A CA  1 
ATOM   2360 C  C   . GLN A 1 292 ? -6.46261  32.53459 -20.19189 1.000 14.34795 ? 292  GLN A C   1 
ATOM   2361 O  O   . GLN A 1 292 ? -6.88462  31.45110 -19.76370 1.000 13.81634 ? 292  GLN A O   1 
ATOM   2362 C  CB  . GLN A 1 292 ? -7.32629  34.63265 -19.11965 1.000 9.39691  ? 292  GLN A CB  1 
ATOM   2363 C  CG  . GLN A 1 292 ? -8.64500  33.98054 -18.77227 1.000 10.52082 ? 292  GLN A CG  1 
ATOM   2364 C  CD  . GLN A 1 292 ? -9.75797  34.98858 -18.79783 1.000 13.44312 ? 292  GLN A CD  1 
ATOM   2365 O  OE1 . GLN A 1 292 ? -10.05558 35.55633 -19.84376 1.000 11.87409 ? 292  GLN A OE1 1 
ATOM   2366 N  NE2 . GLN A 1 292 ? -10.35203 35.25539 -17.63811 1.000 11.55877 ? 292  GLN A NE2 1 
ATOM   2367 N  N   . ALA A 1 293 ? -6.28906  32.76646 -21.49549 1.000 13.30614 ? 293  ALA A N   1 
ATOM   2368 C  CA  . ALA A 1 293 ? -6.57776  31.72349 -22.47814 1.000 12.43690 ? 293  ALA A CA  1 
ATOM   2369 C  C   . ALA A 1 293 ? -5.65887  30.52575 -22.28911 1.000 16.39815 ? 293  ALA A C   1 
ATOM   2370 O  O   . ALA A 1 293 ? -6.10255  29.37107 -22.36207 1.000 11.80875 ? 293  ALA A O   1 
ATOM   2371 C  CB  . ALA A 1 293 ? -6.43711  32.27763 -23.89831 1.000 13.60800 ? 293  ALA A CB  1 
ATOM   2372 N  N   . ALA A 1 294 ? -4.37212  30.77931 -22.03917 1.000 13.65863 ? 294  ALA A N   1 
ATOM   2373 C  CA  . ALA A 1 294 ? -3.44924  29.67783 -21.78468 1.000 16.76197 ? 294  ALA A CA  1 
ATOM   2374 C  C   . ALA A 1 294 ? -3.84925  28.91307 -20.52970 1.000 12.91127 ? 294  ALA A C   1 
ATOM   2375 O  O   . ALA A 1 294 ? -3.78480  27.67850 -20.49519 1.000 13.53283 ? 294  ALA A O   1 
ATOM   2376 C  CB  . ALA A 1 294 ? -2.01813  30.20696 -21.66766 1.000 15.08376 ? 294  ALA A CB  1 
ATOM   2377 N  N   . ARG A 1 295 ? -4.27402  29.63039 -19.48747 1.000 13.96889 ? 295  ARG A N   1 
ATOM   2378 C  CA  . ARG A 1 295 ? -4.76344  28.97086 -18.28179 1.000 13.89549 ? 295  ARG A CA  1 
ATOM   2379 C  C   . ARG A 1 295 ? -5.98650  28.10477 -18.58634 1.000 12.31459 ? 295  ARG A C   1 
ATOM   2380 O  O   . ARG A 1 295 ? -6.08321  26.95772 -18.13106 1.000 13.02464 ? 295  ARG A O   1 
ATOM   2381 C  CB  . ARG A 1 295 ? -5.07777  30.02904 -17.21556 1.000 13.58115 ? 295  ARG A CB  1 
ATOM   2382 C  CG  . ARG A 1 295 ? -5.92999  29.54962 -16.05165 1.000 12.64609 ? 295  ARG A CG  1 
ATOM   2383 C  CD  . ARG A 1 295 ? -5.23213  28.47177 -15.21922 1.000 12.40327 ? 295  ARG A CD  1 
ATOM   2384 N  NE  . ARG A 1 295 ? -5.57827  28.60594 -13.80535 1.000 13.79660 ? 295  ARG A NE  1 
ATOM   2385 C  CZ  . ARG A 1 295 ? -5.24621  27.73024 -12.86243 1.000 14.61290 ? 295  ARG A CZ  1 
ATOM   2386 N  NH1 . ARG A 1 295 ? -4.56173  26.63637 -13.17525 1.000 15.25465 ? 295  ARG A NH1 1 
ATOM   2387 N  NH2 . ARG A 1 295 ? -5.59319  27.95535 -11.60591 1.000 13.85603 ? 295  ARG A NH2 1 
ATOM   2388 N  N   . TYR A 1 296 ? -6.94218  28.64587 -19.34723 1.000 12.97536 ? 296  TYR A N   1 
ATOM   2389 C  CA  . TYR A 1 296 ? -8.14242  27.87979 -19.67416 1.000 14.98669 ? 296  TYR A CA  1 
ATOM   2390 C  C   . TYR A 1 296 ? -7.79894  26.65881 -20.52137 1.000 14.47098 ? 296  TYR A C   1 
ATOM   2391 O  O   . TYR A 1 296 ? -8.39701  25.59151 -20.35729 1.000 17.01772 ? 296  TYR A O   1 
ATOM   2392 C  CB  . TYR A 1 296 ? -9.13602  28.77320 -20.40784 1.000 13.12747 ? 296  TYR A CB  1 
ATOM   2393 C  CG  . TYR A 1 296 ? -10.23978 29.35779 -19.54602 1.000 15.28046 ? 296  TYR A CG  1 
ATOM   2394 C  CD1 . TYR A 1 296 ? -11.18732 28.53408 -18.92615 1.000 12.72877 ? 296  TYR A CD1 1 
ATOM   2395 C  CD2 . TYR A 1 296 ? -10.35400 30.73718 -19.37081 1.000 12.24827 ? 296  TYR A CD2 1 
ATOM   2396 C  CE1 . TYR A 1 296 ? -12.22377 29.07766 -18.15898 1.000 12.20024 ? 296  TYR A CE1 1 
ATOM   2397 C  CE2 . TYR A 1 296 ? -11.39414 31.28954 -18.60773 1.000 12.35292 ? 296  TYR A CE2 1 
ATOM   2398 C  CZ  . TYR A 1 296 ? -12.31927 30.45198 -18.00428 1.000 13.85427 ? 296  TYR A CZ  1 
ATOM   2399 O  OH  . TYR A 1 296 ? -13.33711 30.99174 -17.24488 1.000 12.84911 ? 296  TYR A OH  1 
ATOM   2400 N  N   . ASP A 1 297 ? -6.83695  26.80346 -21.43713 1.000 13.94480 ? 297  ASP A N   1 
ATOM   2401 C  CA  . ASP A 1 297 ? -6.38025  25.67350 -22.24271 1.000 15.80961 ? 297  ASP A CA  1 
ATOM   2402 C  C   . ASP A 1 297 ? -5.87875  24.53262 -21.36096 1.000 14.80992 ? 297  ASP A C   1 
ATOM   2403 O  O   . ASP A 1 297 ? -6.30577  23.38085 -21.51442 1.000 14.77415 ? 297  ASP A O   1 
ATOM   2404 C  CB  . ASP A 1 297 ? -5.28435  26.14062 -23.21106 1.000 15.75732 ? 297  ASP A CB  1 
ATOM   2405 C  CG  . ASP A 1 297 ? -4.77846  25.02561 -24.12115 1.000 19.92062 ? 297  ASP A CG  1 
ATOM   2406 O  OD1 . ASP A 1 297 ? -5.59720  24.28184 -24.72586 1.000 25.57983 ? 297  ASP A OD1 1 
ATOM   2407 O  OD2 . ASP A 1 297 ? -3.54157  24.91215 -24.24460 1.000 26.23929 ? 297  ASP A OD2 1 
ATOM   2408 N  N   . ARG A 1 298 ? -4.97342  24.83307 -20.42529 1.000 14.02994 ? 298  ARG A N   1 
ATOM   2409 C  CA  . ARG A 1 298 ? -4.47004  23.79032 -19.53136 1.000 15.33590 ? 298  ARG A CA  1 
ATOM   2410 C  C   . ARG A 1 298 ? -5.59413  23.23239 -18.66791 1.000 16.68452 ? 298  ARG A C   1 
ATOM   2411 O  O   . ARG A 1 298 ? -5.67185  22.01852 -18.42571 1.000 11.12356 ? 298  ARG A O   1 
ATOM   2412 C  CB  . ARG A 1 298 ? -3.35463  24.33910 -18.63886 1.000 18.09518 ? 298  ARG A CB  1 
ATOM   2413 C  CG  . ARG A 1 298 ? -2.12749  24.84884 -19.36581 1.000 17.43768 ? 298  ARG A CG  1 
ATOM   2414 C  CD  . ARG A 1 298 ? -0.99797  25.20126 -18.37240 1.000 24.54906 ? 298  ARG A CD  1 
ATOM   2415 N  NE  . ARG A 1 298 ? -1.37443  26.25704 -17.42606 1.000 18.71782 ? 298  ARG A NE  1 
ATOM   2416 C  CZ  . ARG A 1 298 ? -1.24262  27.55571 -17.67491 1.000 20.50027 ? 298  ARG A CZ  1 
ATOM   2417 N  NH1 . ARG A 1 298 ? -0.74100  27.95412 -18.84377 1.000 19.13660 ? 298  ARG A NH1 1 
ATOM   2418 N  NH2 . ARG A 1 298 ? -1.60482  28.45518 -16.76599 1.000 24.16687 ? 298  ARG A NH2 1 
ATOM   2419 N  N   . LEU A 1 299 ? -6.48241  24.11185 -18.20982 1.000 12.27762 ? 299  LEU A N   1 
ATOM   2420 C  CA  . LEU A 1 299 ? -7.53212  23.71122 -17.28381 1.000 14.48563 ? 299  LEU A CA  1 
ATOM   2421 C  C   . LEU A 1 299 ? -8.46880  22.70597 -17.92720 1.000 14.12825 ? 299  LEU A C   1 
ATOM   2422 O  O   . LEU A 1 299 ? -8.77446  21.65398 -17.34842 1.000 11.42348 ? 299  LEU A O   1 
ATOM   2423 C  CB  . LEU A 1 299 ? -8.30992  24.94542 -16.83481 1.000 15.19868 ? 299  LEU A CB  1 
ATOM   2424 C  CG  . LEU A 1 299 ? -9.23433  24.67851 -15.66457 1.000 17.90078 ? 299  LEU A CG  1 
ATOM   2425 C  CD1 . LEU A 1 299 ? -8.38023  24.53275 -14.41194 1.000 19.82254 ? 299  LEU A CD1 1 
ATOM   2426 C  CD2 . LEU A 1 299 ? -10.25816 25.80841 -15.51971 1.000 19.30543 ? 299  LEU A CD2 1 
ATOM   2427 N  N   . PHE A 1 300 ? -8.94203  23.01553 -19.13141 1.000 12.22770 ? 300  PHE A N   1 
ATOM   2428 C  CA  . PHE A 1 300 ? -9.90702  22.12436 -19.74786 1.000 12.91494 ? 300  PHE A CA  1 
ATOM   2429 C  C   . PHE A 1 300 ? -9.23857  20.87639 -20.30631 1.000 13.14387 ? 300  PHE A C   1 
ATOM   2430 O  O   . PHE A 1 300 ? -9.86498  19.81251 -20.34818 1.000 11.92328 ? 300  PHE A O   1 
ATOM   2431 C  CB  . PHE A 1 300 ? -10.72284 22.89201 -20.79598 1.000 11.75573 ? 300  PHE A CB  1 
ATOM   2432 C  CG  . PHE A 1 300 ? -11.95588 23.53714 -20.20662 1.000 11.56762 ? 300  PHE A CG  1 
ATOM   2433 C  CD1 . PHE A 1 300 ? -11.85113 24.71712 -19.47386 1.000 12.34778 ? 300  PHE A CD1 1 
ATOM   2434 C  CD2 . PHE A 1 300 ? -13.20191 22.93279 -20.32365 1.000 10.99934 ? 300  PHE A CD2 1 
ATOM   2435 C  CE1 . PHE A 1 300 ? -12.98432 25.30794 -18.89474 1.000 9.82140  ? 300  PHE A CE1 1 
ATOM   2436 C  CE2 . PHE A 1 300 ? -14.33334 23.50207 -19.74070 1.000 12.98084 ? 300  PHE A CE2 1 
ATOM   2437 C  CZ  . PHE A 1 300 ? -14.22517 24.69081 -19.02899 1.000 12.40407 ? 300  PHE A CZ  1 
ATOM   2438 N  N   . LYS A 1 301 ? -7.96452  20.95789 -20.68619 1.000 11.46708 ? 301  LYS A N   1 
ATOM   2439 C  CA  . LYS A 1 301 ? -7.24678  19.73375 -21.01687 1.000 14.31010 ? 301  LYS A CA  1 
ATOM   2440 C  C   . LYS A 1 301 ? -7.21981  18.79869 -19.81443 1.000 12.62674 ? 301  LYS A C   1 
ATOM   2441 O  O   . LYS A 1 301 ? -7.39567  17.57984 -19.95650 1.000 13.46979 ? 301  LYS A O   1 
ATOM   2442 C  CB  . LYS A 1 301 ? -5.82743  20.06737 -21.48980 1.000 13.20061 ? 301  LYS A CB  1 
ATOM   2443 C  CG  . LYS A 1 301 ? -5.32156  19.18372 -22.61449 1.000 28.54590 ? 301  LYS A CG  1 
ATOM   2444 C  CD  . LYS A 1 301 ? -4.14838  19.83613 -23.35783 1.000 36.56999 ? 301  LYS A CD  1 
ATOM   2445 C  CE  . LYS A 1 301 ? -4.48582  21.26152 -23.81646 1.000 31.60213 ? 301  LYS A CE  1 
ATOM   2446 N  NZ  . LYS A 1 301 ? -3.42956  21.87792 -24.68576 1.000 32.96087 ? 301  LYS A NZ  1 
ATOM   2447 N  N   . LEU A 1 302 ? -7.05777  19.36216 -18.61359 1.000 12.61737 ? 302  LEU A N   1 
ATOM   2448 C  CA  . LEU A 1 302 ? -7.04727  18.54833 -17.40447 1.000 14.27926 ? 302  LEU A CA  1 
ATOM   2449 C  C   . LEU A 1 302 ? -8.43576  18.00395 -17.09739 1.000 18.16173 ? 302  LEU A C   1 
ATOM   2450 O  O   . LEU A 1 302 ? -8.58460  16.82519 -16.75073 1.000 14.93545 ? 302  LEU A O   1 
ATOM   2451 C  CB  . LEU A 1 302 ? -6.51518  19.35690 -16.22115 1.000 12.78772 ? 302  LEU A CB  1 
ATOM   2452 C  CG  . LEU A 1 302 ? -6.58239  18.65086 -14.86360 1.000 19.07293 ? 302  LEU A CG  1 
ATOM   2453 C  CD1 . LEU A 1 302 ? -5.68278  17.41597 -14.82661 1.000 18.79163 ? 302  LEU A CD1 1 
ATOM   2454 C  CD2 . LEU A 1 302 ? -6.24190  19.59424 -13.71905 1.000 14.96073 ? 302  LEU A CD2 1 
ATOM   2455 N  N   . TYR A 1 303 ? -9.46902  18.83796 -17.21581 1.000 12.82723 ? 303  TYR A N   1 
ATOM   2456 C  CA  . TYR A 1 303 ? -10.81931 18.31832 -17.02022 1.000 14.10613 ? 303  TYR A CA  1 
ATOM   2457 C  C   . TYR A 1 303 ? -11.08710 17.16035 -17.96515 1.000 14.46624 ? 303  TYR A C   1 
ATOM   2458 O  O   . TYR A 1 303 ? -11.65468 16.13986 -17.56035 1.000 13.72184 ? 303  TYR A O   1 
ATOM   2459 C  CB  . TYR A 1 303 ? -11.85395 19.42396 -17.22395 1.000 13.81828 ? 303  TYR A CB  1 
ATOM   2460 C  CG  . TYR A 1 303 ? -11.82409 20.48994 -16.16129 1.000 10.31060 ? 303  TYR A CG  1 
ATOM   2461 C  CD1 . TYR A 1 303 ? -11.27447 20.23868 -14.90833 1.000 10.67359 ? 303  TYR A CD1 1 
ATOM   2462 C  CD2 . TYR A 1 303 ? -12.34863 21.75135 -16.40319 1.000 17.49142 ? 303  TYR A CD2 1 
ATOM   2463 C  CE1 . TYR A 1 303 ? -11.23804 21.22098 -13.92487 1.000 11.60364 ? 303  TYR A CE1 1 
ATOM   2464 C  CE2 . TYR A 1 303 ? -12.32583 22.73737 -15.42339 1.000 17.76294 ? 303  TYR A CE2 1 
ATOM   2465 C  CZ  . TYR A 1 303 ? -11.76540 22.46477 -14.18689 1.000 13.04658 ? 303  TYR A CZ  1 
ATOM   2466 O  OH  . TYR A 1 303 ? -11.74666 23.44269 -13.21822 1.000 15.43972 ? 303  TYR A OH  1 
ATOM   2467 N  N   . GLU A 1 304 ? -10.65890 17.28631 -19.22807 1.000 13.00069 ? 304  GLU A N   1 
ATOM   2468 C  CA  . GLU A 1 304 ? -10.88320 16.20066 -20.17764 1.000 14.58702 ? 304  GLU A CA  1 
ATOM   2469 C  C   . GLU A 1 304 ? -10.11402 14.94925 -19.77279 1.000 14.71048 ? 304  GLU A C   1 
ATOM   2470 O  O   . GLU A 1 304 ? -10.66366 13.84007 -19.80901 1.000 17.82670 ? 304  GLU A O   1 
ATOM   2471 C  CB  . GLU A 1 304 ? -10.50036 16.64095 -21.59056 1.000 15.33006 ? 304  GLU A CB  1 
ATOM   2472 C  CG  . GLU A 1 304 ? -11.57073 17.46405 -22.23618 1.000 15.85386 ? 304  GLU A CG  1 
ATOM   2473 C  CD  . GLU A 1 304 ? -11.41483 17.53890 -23.73175 1.000 16.71176 ? 304  GLU A CD  1 
ATOM   2474 O  OE1 . GLU A 1 304 ? -10.52082 18.27412 -24.19154 1.000 16.64646 ? 304  GLU A OE1 1 
ATOM   2475 O  OE2 . GLU A 1 304 ? -12.18967 16.86367 -24.43565 1.000 15.84056 ? 304  GLU A OE2 1 
ATOM   2476 N  N   . LYS A 1 305 ? -8.84811  15.10727 -19.36643 1.000 17.01110 ? 305  LYS A N   1 
ATOM   2477 C  CA  . LYS A 1 305 ? -8.08269  13.96542 -18.86185 1.000 13.94313 ? 305  LYS A CA  1 
ATOM   2478 C  C   . LYS A 1 305 ? -8.84452  13.26077 -17.74928 1.000 18.85347 ? 305  LYS A C   1 
ATOM   2479 O  O   . LYS A 1 305 ? -8.87447  12.02570 -17.68477 1.000 17.07201 ? 305  LYS A O   1 
ATOM   2480 C  CB  . LYS A 1 305 ? -6.70764  14.42314 -18.36105 1.000 14.15314 ? 305  LYS A CB  1 
ATOM   2481 C  CG  . LYS A 1 305 ? -5.75461  13.29076 -17.90745 1.000 15.11017 ? 305  LYS A CG  1 
ATOM   2482 C  CD  . LYS A 1 305 ? -4.49443  13.87310 -17.25652 1.000 20.33717 ? 305  LYS A CD  1 
ATOM   2483 C  CE  . LYS A 1 305 ? -3.51501  12.80650 -16.78292 1.000 22.51653 ? 305  LYS A CE  1 
ATOM   2484 N  NZ  . LYS A 1 305 ? -2.46622  13.43331 -15.91560 1.000 22.74144 ? 305  LYS A NZ  1 
ATOM   2485 N  N   . LEU A 1 306 ? -9.49905  14.03584 -16.88171 1.000 15.84180 ? 306  LEU A N   1 
ATOM   2486 C  CA  . LEU A 1 306 ? -10.22582 13.50747 -15.73924 1.000 15.28431 ? 306  LEU A CA  1 
ATOM   2487 C  C   . LEU A 1 306 ? -11.71293 13.34821 -16.02031 1.000 17.57037 ? 306  LEU A C   1 
ATOM   2488 O  O   . LEU A 1 306 ? -12.51735 13.32617 -15.07786 1.000 15.41908 ? 306  LEU A O   1 
ATOM   2489 C  CB  . LEU A 1 306 ? -10.00845 14.41299 -14.52607 1.000 18.17948 ? 306  LEU A CB  1 
ATOM   2490 C  CG  . LEU A 1 306 ? -8.56138  14.70714 -14.11257 1.000 20.02603 ? 306  LEU A CG  1 
ATOM   2491 C  CD1 . LEU A 1 306 ? -8.50621  15.62580 -12.89388 1.000 15.20934 ? 306  LEU A CD1 1 
ATOM   2492 C  CD2 . LEU A 1 306 ? -7.82944  13.41130 -13.82956 1.000 20.51345 ? 306  LEU A CD2 1 
ATOM   2493 N  N   . SER A 1 307 ? -12.10190 13.23253 -17.29635 1.000 16.38267 ? 307  SER A N   1 
ATOM   2494 C  CA  . SER A 1 307 ? -13.52213 13.30073 -17.63104 1.000 17.45825 ? 307  SER A CA  1 
ATOM   2495 C  C   . SER A 1 307 ? -14.30906 12.12574 -17.07420 1.000 16.22059 ? 307  SER A C   1 
ATOM   2496 O  O   . SER A 1 307 ? -15.53940 12.21882 -16.95350 1.000 14.36966 ? 307  SER A O   1 
ATOM   2497 C  CB  . SER A 1 307 ? -13.72020 13.37662 -19.14368 1.000 15.91666 ? 307  SER A CB  1 
ATOM   2498 O  OG  . SER A 1 307 ? -13.51599 12.10678 -19.73279 1.000 17.89024 ? 307  SER A OG  1 
ATOM   2499 N  N   . ASP A 1 308 ? -13.64130 11.02807 -16.71562 1.000 16.56159 ? 308  ASP A N   1 
ATOM   2500 C  CA  . ASP A 1 308 ? -14.38897 9.91234  -16.14762 1.000 18.93169 ? 308  ASP A CA  1 
ATOM   2501 C  C   . ASP A 1 308 ? -14.68497 10.11629 -14.66980 1.000 19.68397 ? 308  ASP A C   1 
ATOM   2502 O  O   . ASP A 1 308 ? -15.36621 9.28157  -14.06831 1.000 23.00740 ? 308  ASP A O   1 
ATOM   2503 C  CB  . ASP A 1 308 ? -13.64473 8.58866  -16.37504 1.000 22.54525 ? 308  ASP A CB  1 
ATOM   2504 C  CG  . ASP A 1 308 ? -12.30431 8.54832  -15.69917 1.000 28.41463 ? 308  ASP A CG  1 
ATOM   2505 O  OD1 . ASP A 1 308 ? -11.54686 9.54762  -15.78096 1.000 33.94080 ? 308  ASP A OD1 1 
ATOM   2506 O  OD2 . ASP A 1 308 ? -11.99848 7.50872  -15.08039 1.000 44.35376 ? 308  ASP A OD2 1 
ATOM   2507 N  N   . LYS A 1 309 ? -14.21428 11.22090 -14.09027 1.000 14.86193 ? 309  LYS A N   1 
ATOM   2508 C  CA  . LYS A 1 309 ? -14.43962 11.55950 -12.69581 1.000 15.76309 ? 309  LYS A CA  1 
ATOM   2509 C  C   . LYS A 1 309 ? -15.19432 12.87307 -12.53023 1.000 14.77365 ? 309  LYS A C   1 
ATOM   2510 O  O   . LYS A 1 309 ? -15.44295 13.29269 -11.39479 1.000 17.91269 ? 309  LYS A O   1 
ATOM   2511 C  CB  . LYS A 1 309 ? -13.09477 11.63215 -11.95584 1.000 18.09468 ? 309  LYS A CB  1 
ATOM   2512 C  CG  . LYS A 1 309 ? -12.26376 10.35654 -12.07100 1.000 19.98015 ? 309  LYS A CG  1 
ATOM   2513 C  CD  . LYS A 1 309 ? -10.79159 10.59684 -11.72561 1.000 21.98640 ? 309  LYS A CD  1 
ATOM   2514 C  CE  . LYS A 1 309 ? -9.94084  9.34623  -11.98735 1.000 29.19537 ? 309  LYS A CE  1 
ATOM   2515 N  NZ  . LYS A 1 309 ? -8.47802  9.67331  -12.07611 1.000 25.27098 ? 309  LYS A NZ  1 
ATOM   2516 N  N   . ILE A 1 310 ? -15.57556 13.52217 -13.62609 1.000 16.52164 ? 310  ILE A N   1 
ATOM   2517 C  CA  . ILE A 1 310 ? -16.22328 14.82820 -13.61454 1.000 11.12349 ? 310  ILE A CA  1 
ATOM   2518 C  C   . ILE A 1 310 ? -17.47361 14.73401 -14.47420 1.000 12.33356 ? 310  ILE A C   1 
ATOM   2519 O  O   . ILE A 1 310 ? -17.37966 14.42531 -15.66212 1.000 13.19713 ? 310  ILE A O   1 
ATOM   2520 C  CB  . ILE A 1 310 ? -15.29491 15.92759 -14.15998 1.000 10.78789 ? 310  ILE A CB  1 
ATOM   2521 C  CG1 . ILE A 1 310 ? -14.02307 16.05004 -13.31801 1.000 15.15350 ? 310  ILE A CG1 1 
ATOM   2522 C  CG2 . ILE A 1 310 ? -16.05086 17.25942 -14.24590 1.000 11.05853 ? 310  ILE A CG2 1 
ATOM   2523 C  CD1 . ILE A 1 310 ? -12.98495 16.95659 -13.96254 1.000 14.49635 ? 310  ILE A CD1 1 
ATOM   2524 N  N   . SER A 1 311 ? -18.63703 15.03217 -13.89817 1.000 12.09566 ? 311  SER A N   1 
ATOM   2525 C  CA  . SER A 1 311 ? -19.88166 14.95533 -14.65935 1.000 11.78564 ? 311  SER A CA  1 
ATOM   2526 C  C   . SER A 1 311 ? -20.34845 16.29761 -15.21507 1.000 13.49961 ? 311  SER A C   1 
ATOM   2527 O  O   . SER A 1 311 ? -21.17321 16.31759 -16.14405 1.000 12.20020 ? 311  SER A O   1 
ATOM   2528 C  CB  . SER A 1 311 ? -20.99600 14.37002 -13.78463 1.000 11.49369 ? 311  SER A CB  1 
ATOM   2529 O  OG  . SER A 1 311 ? -21.23426 15.21530 -12.66239 1.000 12.02857 ? 311  SER A OG  1 
ATOM   2530 N  N   . ASN A 1 312 ? -19.81609 17.40444 -14.70638 1.000 12.23666 ? 312  ASN A N   1 
ATOM   2531 C  CA  . ASN A 1 312 ? -20.31539 18.72322 -15.06696 1.000 10.52875 ? 312  ASN A CA  1 
ATOM   2532 C  C   . ASN A 1 312 ? -19.25668 19.76990 -14.75980 1.000 9.20438  ? 312  ASN A C   1 
ATOM   2533 O  O   . ASN A 1 312 ? -18.57955 19.70272 -13.72870 1.000 10.20848 ? 312  ASN A O   1 
ATOM   2534 C  CB  . ASN A 1 312 ? -21.60275 19.06117 -14.30264 1.000 10.93938 ? 312  ASN A CB  1 
ATOM   2535 C  CG  . ASN A 1 312 ? -21.90493 20.55473 -14.29124 1.000 14.07026 ? 312  ASN A CG  1 
ATOM   2536 O  OD1 . ASN A 1 312 ? -21.67181 21.23381 -13.29311 1.000 12.04790 ? 312  ASN A OD1 1 
ATOM   2537 N  ND2 . ASN A 1 312 ? -22.41604 21.07344 -15.41183 1.000 11.43351 ? 312  ASN A ND2 1 
ATOM   2538 N  N   . VAL A 1 313 ? -19.13687 20.74087 -15.65387 1.000 10.11330 ? 313  VAL A N   1 
ATOM   2539 C  CA  . VAL A 1 313 ? -18.35064 21.94673 -15.41908 1.000 10.49248 ? 313  VAL A CA  1 
ATOM   2540 C  C   . VAL A 1 313 ? -19.31430 23.10679 -15.63278 1.000 9.70300  ? 313  VAL A C   1 
ATOM   2541 O  O   . VAL A 1 313 ? -19.82261 23.29419 -16.74381 1.000 9.59895  ? 313  VAL A O   1 
ATOM   2542 C  CB  . VAL A 1 313 ? -17.13159 22.04770 -16.34833 1.000 10.05733 ? 313  VAL A CB  1 
ATOM   2543 C  CG1 . VAL A 1 313 ? -16.43018 23.41345 -16.18873 1.000 8.35270  ? 313  VAL A CG1 1 
ATOM   2544 C  CG2 . VAL A 1 313 ? -16.15452 20.91315 -16.08163 1.000 7.71966  ? 313  VAL A CG2 1 
ATOM   2545 N  N   . THR A 1 314 ? -19.59025 23.85993 -14.56944 1.000 8.88584  ? 314  THR A N   1 
ATOM   2546 C  CA  . THR A 1 314 ? -20.49064 25.00879 -14.60900 1.000 8.53141  ? 314  THR A CA  1 
ATOM   2547 C  C   . THR A 1 314 ? -19.68651 26.27813 -14.35406 1.000 8.79966  ? 314  THR A C   1 
ATOM   2548 O  O   . THR A 1 314 ? -18.93593 26.35121 -13.37272 1.000 8.78267  ? 314  THR A O   1 
ATOM   2549 C  CB  . THR A 1 314 ? -21.60792 24.87018 -13.56268 1.000 9.88890  ? 314  THR A CB  1 
ATOM   2550 O  OG1 . THR A 1 314 ? -22.42875 23.72415 -13.85747 1.000 9.04804  ? 314  THR A OG1 1 
ATOM   2551 C  CG2 . THR A 1 314 ? -22.50276 26.12411 -13.53552 1.000 7.10510  ? 314  THR A CG2 1 
ATOM   2552 N  N   . PHE A 1 315 ? -19.83183 27.26335 -15.24663 1.000 10.41911 ? 315  PHE A N   1 
ATOM   2553 C  CA  . PHE A 1 315 ? -19.26765 28.60005 -15.04430 1.000 10.26737 ? 315  PHE A CA  1 
ATOM   2554 C  C   . PHE A 1 315 ? -20.22342 29.41559 -14.18790 1.000 13.37687 ? 315  PHE A C   1 
ATOM   2555 O  O   . PHE A 1 315 ? -21.44497 29.31049 -14.33801 1.000 9.24528  ? 315  PHE A O   1 
ATOM   2556 C  CB  . PHE A 1 315 ? -19.07058 29.34338 -16.37798 1.000 10.32337 ? 315  PHE A CB  1 
ATOM   2557 C  CG  . PHE A 1 315 ? -18.06514 28.71099 -17.31135 1.000 12.19476 ? 315  PHE A CG  1 
ATOM   2558 C  CD1 . PHE A 1 315 ? -16.71580 29.03969 -17.22814 1.000 10.50521 ? 315  PHE A CD1 1 
ATOM   2559 C  CD2 . PHE A 1 315 ? -18.47386 27.81181 -18.29209 1.000 12.34462 ? 315  PHE A CD2 1 
ATOM   2560 C  CE1 . PHE A 1 315 ? -15.77548 28.46779 -18.11747 1.000 12.46003 ? 315  PHE A CE1 1 
ATOM   2561 C  CE2 . PHE A 1 315 ? -17.53804 27.23520 -19.16857 1.000 10.17568 ? 315  PHE A CE2 1 
ATOM   2562 C  CZ  . PHE A 1 315 ? -16.18713 27.57240 -19.06690 1.000 11.84766 ? 315  PHE A CZ  1 
ATOM   2563 N  N   . TRP A 1 316 ? -19.67925 30.26285 -13.31507 1.000 13.57025 ? 316  TRP A N   1 
ATOM   2564 C  CA  . TRP A 1 316 ? -20.54796 31.10133 -12.48467 1.000 10.31397 ? 316  TRP A CA  1 
ATOM   2565 C  C   . TRP A 1 316 ? -20.94845 32.37715 -13.22770 1.000 11.51801 ? 316  TRP A C   1 
ATOM   2566 O  O   . TRP A 1 316 ? -20.72176 33.50087 -12.77643 1.000 12.23066 ? 316  TRP A O   1 
ATOM   2567 C  CB  . TRP A 1 316 ? -19.87716 31.43046 -11.16170 1.000 11.83670 ? 316  TRP A CB  1 
ATOM   2568 C  CG  . TRP A 1 316 ? -20.91083 31.69887 -10.09774 1.000 15.90768 ? 316  TRP A CG  1 
ATOM   2569 C  CD1 . TRP A 1 316 ? -21.17203 32.89347 -9.48662  1.000 13.50156 ? 316  TRP A CD1 1 
ATOM   2570 C  CD2 . TRP A 1 316 ? -21.84155 30.75181 -9.54760  1.000 12.69434 ? 316  TRP A CD2 1 
ATOM   2571 N  NE1 . TRP A 1 316 ? -22.21156 32.74965 -8.58828  1.000 15.59666 ? 316  TRP A NE1 1 
ATOM   2572 C  CE2 . TRP A 1 316 ? -22.63620 31.44492 -8.60473  1.000 13.09630 ? 316  TRP A CE2 1 
ATOM   2573 C  CE3 . TRP A 1 316 ? -22.07579 29.38502 -9.75588  1.000 11.30498 ? 316  TRP A CE3 1 
ATOM   2574 C  CZ2 . TRP A 1 316 ? -23.63197 30.81553 -7.85823  1.000 12.69120 ? 316  TRP A CZ2 1 
ATOM   2575 C  CZ3 . TRP A 1 316 ? -23.08333 28.75820 -9.02243  1.000 14.03312 ? 316  TRP A CZ3 1 
ATOM   2576 C  CH2 . TRP A 1 316 ? -23.85071 29.48153 -8.08046  1.000 13.58321 ? 316  TRP A CH2 1 
ATOM   2577 N  N   . GLY A 1 317 ? -21.54741 32.17991 -14.38262 1.000 10.60667 ? 317  GLY A N   1 
ATOM   2578 C  CA  . GLY A 1 317 ? -22.03327 33.28139 -15.19070 1.000 9.12112  ? 317  GLY A CA  1 
ATOM   2579 C  C   . GLY A 1 317 ? -22.08252 32.86848 -16.64748 1.000 9.37242  ? 317  GLY A C   1 
ATOM   2580 O  O   . GLY A 1 317 ? -21.77375 31.73503 -17.00843 1.000 10.81790 ? 317  GLY A O   1 
ATOM   2581 N  N   . ILE A 1 318 ? -22.50116 33.82059 -17.48036 1.000 11.12687 ? 318  ILE A N   1 
ATOM   2582 C  CA  . ILE A 1 318 ? -22.64149 33.61874 -18.92409 1.000 9.83842  ? 318  ILE A CA  1 
ATOM   2583 C  C   . ILE A 1 318 ? -21.54521 34.35667 -19.68727 1.000 12.30465 ? 318  ILE A C   1 
ATOM   2584 O  O   . ILE A 1 318 ? -20.73375 33.73984 -20.37770 1.000 10.55860 ? 318  ILE A O   1 
ATOM   2585 C  CB  . ILE A 1 318 ? -24.04275 34.04742 -19.41520 1.000 6.55356  ? 318  ILE A CB  1 
ATOM   2586 C  CG1 . ILE A 1 318 ? -25.15666 33.31688 -18.64449 1.000 10.52482 ? 318  ILE A CG1 1 
ATOM   2587 C  CG2 . ILE A 1 318 ? -24.15873 33.86191 -20.93370 1.000 8.68065  ? 318  ILE A CG2 1 
ATOM   2588 C  CD1 . ILE A 1 318 ? -26.57778 33.80749 -18.98657 1.000 10.30825 ? 318  ILE A CD1 1 
ATOM   2589 N  N   . ALA A 1 319 ? -21.50516 35.68133 -19.57180 1.000 13.29572 ? 319  ALA A N   1 
ATOM   2590 C  CA  . ALA A 1 319 ? -20.52513 36.48728 -20.29171 1.000 10.69932 ? 319  ALA A CA  1 
ATOM   2591 C  C   . ALA A 1 319 ? -19.99426 37.58553 -19.37281 1.000 8.57458  ? 319  ALA A C   1 
ATOM   2592 O  O   . ALA A 1 319 ? -20.58816 37.89888 -18.34342 1.000 8.98045  ? 319  ALA A O   1 
ATOM   2593 C  CB  . ALA A 1 319 ? -21.13289 37.07349 -21.57485 1.000 9.52568  ? 319  ALA A CB  1 
ATOM   2594 N  N   . ASP A 1 320 ? -18.85523 38.16925 -19.76304 1.000 9.29167  ? 320  ASP A N   1 
ATOM   2595 C  CA  . ASP A 1 320 ? -18.09143 39.06337 -18.89027 1.000 12.83557 ? 320  ASP A CA  1 
ATOM   2596 C  C   . ASP A 1 320 ? -18.85559 40.31732 -18.45616 1.000 13.76331 ? 320  ASP A C   1 
ATOM   2597 O  O   . ASP A 1 320 ? -18.39933 41.00751 -17.53604 1.000 11.41110 ? 320  ASP A O   1 
ATOM   2598 C  CB  . ASP A 1 320 ? -16.79025 39.47504 -19.58578 1.000 10.45921 ? 320  ASP A CB  1 
ATOM   2599 C  CG  . ASP A 1 320 ? -15.68325 38.43258 -19.43452 1.000 14.21201 ? 320  ASP A CG  1 
ATOM   2600 O  OD1 . ASP A 1 320 ? -15.90901 37.37735 -18.78336 1.000 12.15926 ? 320  ASP A OD1 1 
ATOM   2601 O  OD2 . ASP A 1 320 ? -14.57683 38.67837 -19.96978 1.000 12.79513 ? 320  ASP A OD2 1 
ATOM   2602 N  N   . ASN A 1 321 ? -19.99425 40.63349 -19.07666 1.000 13.85169 ? 321  ASN A N   1 
ATOM   2603 C  CA  . ASN A 1 321 ? -20.76619 41.78867 -18.63370 1.000 15.62700 ? 321  ASN A CA  1 
ATOM   2604 C  C   . ASN A 1 321 ? -21.42367 41.58238 -17.26979 1.000 17.88237 ? 321  ASN A C   1 
ATOM   2605 O  O   . ASN A 1 321 ? -21.94902 42.54911 -16.70726 1.000 13.70482 ? 321  ASN A O   1 
ATOM   2606 C  CB  . ASN A 1 321 ? -21.84267 42.14828 -19.67387 1.000 13.46225 ? 321  ASN A CB  1 
ATOM   2607 C  CG  . ASN A 1 321 ? -22.80454 41.00356 -19.93859 1.000 15.72500 ? 321  ASN A CG  1 
ATOM   2608 O  OD1 . ASN A 1 321 ? -22.40435 39.84198 -19.94960 1.000 13.05333 ? 321  ASN A OD1 1 
ATOM   2609 N  ND2 . ASN A 1 321 ? -24.08665 41.32656 -20.14658 1.000 17.59037 ? 321  ASN A ND2 1 
ATOM   2610 N  N   . HIS A 1 322 ? -21.40338 40.37127 -16.71385 1.000 11.74376 ? 322  HIS A N   1 
ATOM   2611 C  CA  . HIS A 1 322 ? -22.08769 40.12034 -15.44529 1.000 12.11252 ? 322  HIS A CA  1 
ATOM   2612 C  C   . HIS A 1 322 ? -21.35693 39.00796 -14.70615 1.000 13.70589 ? 322  HIS A C   1 
ATOM   2613 O  O   . HIS A 1 322 ? -21.41750 37.84194 -15.11283 1.000 10.92819 ? 322  HIS A O   1 
ATOM   2614 C  CB  . HIS A 1 322 ? -23.55766 39.75678 -15.67445 1.000 12.83026 ? 322  HIS A CB  1 
ATOM   2615 C  CG  . HIS A 1 322 ? -24.33065 39.55112 -14.41005 1.000 17.16339 ? 322  HIS A CG  1 
ATOM   2616 N  ND1 . HIS A 1 322 ? -25.24972 40.46787 -13.94575 1.000 22.05418 ? 322  HIS A ND1 1 
ATOM   2617 C  CD2 . HIS A 1 322 ? -24.30981 38.54418 -13.50151 1.000 15.83098 ? 322  HIS A CD2 1 
ATOM   2618 C  CE1 . HIS A 1 322 ? -25.76448 40.03279 -12.80715 1.000 26.64871 ? 322  HIS A CE1 1 
ATOM   2619 N  NE2 . HIS A 1 322 ? -25.21316 38.86759 -12.51606 1.000 17.02322 ? 322  HIS A NE2 1 
ATOM   2620 N  N   . THR A 1 323 ? -20.68459 39.36710 -13.61697 1.000 12.82697 ? 323  THR A N   1 
ATOM   2621 C  CA  . THR A 1 323 ? -19.99318 38.39415 -12.77712 1.000 11.92633 ? 323  THR A CA  1 
ATOM   2622 C  C   . THR A 1 323 ? -19.96727 38.88948 -11.34070 1.000 14.74458 ? 323  THR A C   1 
ATOM   2623 O  O   . THR A 1 323 ? -19.64346 40.05540 -11.09331 1.000 12.73647 ? 323  THR A O   1 
ATOM   2624 C  CB  . THR A 1 323 ? -18.55854 38.11632 -13.27603 1.000 11.72113 ? 323  THR A CB  1 
ATOM   2625 O  OG1 . THR A 1 323 ? -17.83118 37.43148 -12.24552 1.000 12.39382 ? 323  THR A OG1 1 
ATOM   2626 C  CG2 . THR A 1 323 ? -17.82376 39.39621 -13.68096 1.000 9.59649  ? 323  THR A CG2 1 
ATOM   2627 N  N   . TRP A 1 324 ? -20.30924 38.00025 -10.39989 1.000 10.22695 ? 324  TRP A N   1 
ATOM   2628 C  CA  . TRP A 1 324 ? -20.17464 38.32799 -8.98504  1.000 12.97267 ? 324  TRP A CA  1 
ATOM   2629 C  C   . TRP A 1 324 ? -18.74287 38.72634 -8.61510  1.000 13.35038 ? 324  TRP A C   1 
ATOM   2630 O  O   . TRP A 1 324 ? -18.53769 39.38044 -7.58740  1.000 13.53981 ? 324  TRP A O   1 
ATOM   2631 C  CB  . TRP A 1 324 ? -20.62984 37.14358 -8.13402  1.000 13.33225 ? 324  TRP A CB  1 
ATOM   2632 C  CG  . TRP A 1 324 ? -19.55231 36.14463 -7.91306  1.000 16.21456 ? 324  TRP A CG  1 
ATOM   2633 C  CD1 . TRP A 1 324 ? -18.91595 35.38445 -8.86439  1.000 17.63797 ? 324  TRP A CD1 1 
ATOM   2634 C  CD2 . TRP A 1 324 ? -18.93561 35.81709 -6.65993  1.000 16.58469 ? 324  TRP A CD2 1 
ATOM   2635 N  NE1 . TRP A 1 324 ? -17.96507 34.58342 -8.26617  1.000 14.66047 ? 324  TRP A NE1 1 
ATOM   2636 C  CE2 . TRP A 1 324 ? -17.95543 34.83584 -6.91854  1.000 16.07487 ? 324  TRP A CE2 1 
ATOM   2637 C  CE3 . TRP A 1 324 ? -19.12684 36.25195 -5.34461  1.000 22.47531 ? 324  TRP A CE3 1 
ATOM   2638 C  CZ2 . TRP A 1 324 ? -17.16757 34.28572 -5.91053  1.000 18.61493 ? 324  TRP A CZ2 1 
ATOM   2639 C  CZ3 . TRP A 1 324 ? -18.34845 35.69838 -4.34481  1.000 28.06721 ? 324  TRP A CZ3 1 
ATOM   2640 C  CH2 . TRP A 1 324 ? -17.38166 34.72607 -4.63309  1.000 22.50605 ? 324  TRP A CH2 1 
ATOM   2641 N  N   . LEU A 1 325 ? -17.75215 38.38572 -9.44140  1.000 11.74795 ? 325  LEU A N   1 
ATOM   2642 C  CA  . LEU A 1 325 ? -16.38364 38.80032 -9.14580  1.000 10.76460 ? 325  LEU A CA  1 
ATOM   2643 C  C   . LEU A 1 325 ? -16.23427 40.31473 -9.13495  1.000 15.07631 ? 325  LEU A C   1 
ATOM   2644 O  O   . LEU A 1 325 ? -15.29342 40.83200 -8.52024  1.000 14.39656 ? 325  LEU A O   1 
ATOM   2645 C  CB  . LEU A 1 325 ? -15.40403 38.19013 -10.15875 1.000 10.30989 ? 325  LEU A CB  1 
ATOM   2646 C  CG  . LEU A 1 325 ? -15.19658 36.67459 -10.09072 1.000 15.59995 ? 325  LEU A CG  1 
ATOM   2647 C  CD1 . LEU A 1 325 ? -14.05294 36.26650 -11.04119 1.000 10.29389 ? 325  LEU A CD1 1 
ATOM   2648 C  CD2 . LEU A 1 325 ? -14.92348 36.21592 -8.65825  1.000 15.20221 ? 325  LEU A CD2 1 
ATOM   2649 N  N   . ASP A 1 326 ? -17.12929 41.03913 -9.80558  1.000 11.72792 ? 326  ASP A N   1 
ATOM   2650 C  CA  . ASP A 1 326 ? -17.02754 42.49369 -9.79057  1.000 12.54933 ? 326  ASP A CA  1 
ATOM   2651 C  C   . ASP A 1 326 ? -17.18898 43.04946 -8.38082  1.000 13.99184 ? 326  ASP A C   1 
ATOM   2652 O  O   . ASP A 1 326 ? -16.56942 44.06491 -8.04275  1.000 17.39303 ? 326  ASP A O   1 
ATOM   2653 C  CB  . ASP A 1 326 ? -18.05840 43.09804 -10.74734 1.000 12.35014 ? 326  ASP A CB  1 
ATOM   2654 C  CG  . ASP A 1 326 ? -17.66764 42.90570 -12.20574 1.000 15.13645 ? 326  ASP A CG  1 
ATOM   2655 O  OD1 . ASP A 1 326 ? -16.48989 42.53240 -12.44986 1.000 13.98560 ? 326  ASP A OD1 1 
ATOM   2656 O  OD2 . ASP A 1 326 ? -18.52213 43.11299 -13.09781 1.000 15.24890 ? 326  ASP A OD2 1 
ATOM   2657 N  N   . SER A 1 327 ? -17.97869 42.38191 -7.53303  1.000 14.34336 ? 327  SER A N   1 
ATOM   2658 C  CA  . SER A 1 327 ? -18.10778 42.80650 -6.14401  1.000 19.06475 ? 327  SER A CA  1 
ATOM   2659 C  C   . SER A 1 327 ? -16.80025 42.66941 -5.37031  1.000 18.78263 ? 327  SER A C   1 
ATOM   2660 O  O   . SER A 1 327 ? -16.65773 43.28108 -4.30780  1.000 18.67038 ? 327  SER A O   1 
ATOM   2661 C  CB  . SER A 1 327 ? -19.21274 42.00930 -5.44412  1.000 18.65916 ? 327  SER A CB  1 
ATOM   2662 O  OG  . SER A 1 327 ? -18.77446 40.67808 -5.19722  1.000 20.07865 ? 327  SER A OG  1 
ATOM   2663 N  N   . ARG A 1 328 ? -15.84490 41.89317 -5.87321  1.000 15.95159 ? 328  ARG A N   1 
ATOM   2664 C  CA  . ARG A 1 328 ? -14.54016 41.76130 -5.23451  1.000 19.20839 ? 328  ARG A CA  1 
ATOM   2665 C  C   . ARG A 1 328 ? -13.47259 42.60499 -5.91370  1.000 18.79632 ? 328  ARG A C   1 
ATOM   2666 O  O   . ARG A 1 328 ? -12.32432 42.61827 -5.45641  1.000 17.39098 ? 328  ARG A O   1 
ATOM   2667 C  CB  . ARG A 1 328 ? -14.09389 40.29496 -5.22217  1.000 19.04783 ? 328  ARG A CB  1 
ATOM   2668 C  CG  . ARG A 1 328 ? -14.89681 39.41366 -4.29541  1.000 19.85552 ? 328  ARG A CG  1 
ATOM   2669 C  CD  . ARG A 1 328 ? -15.32933 38.11694 -4.97757  1.000 25.83510 ? 328  ARG A CD  1 
ATOM   2670 N  NE  . ARG A 1 328 ? -14.23419 37.16767 -5.22016  1.000 23.13006 ? 328  ARG A NE  1 
ATOM   2671 C  CZ  . ARG A 1 328 ? -13.92071 36.14657 -4.42126  1.000 22.81796 ? 328  ARG A CZ  1 
ATOM   2672 N  NH1 . ARG A 1 328 ? -14.59498 35.92794 -3.29372  1.000 21.24143 ? 328  ARG A NH1 1 
ATOM   2673 N  NH2 . ARG A 1 328 ? -12.92647 35.33931 -4.75515  1.000 24.97825 ? 328  ARG A NH2 1 
ATOM   2674 N  N   . ALA A 1 329 ? -13.82604 43.32011 -6.98338  1.000 15.73822 ? 329  ALA A N   1 
ATOM   2675 C  CA  . ALA A 1 329 ? -12.83858 43.98925 -7.83167  1.000 14.52560 ? 329  ALA A CA  1 
ATOM   2676 C  C   . ALA A 1 329 ? -12.53500 45.36162 -7.23615  1.000 15.20064 ? 329  ALA A C   1 
ATOM   2677 O  O   . ALA A 1 329 ? -13.01817 46.40475 -7.69161  1.000 16.79704 ? 329  ALA A O   1 
ATOM   2678 C  CB  . ALA A 1 329 ? -13.34493 44.07319 -9.26590  1.000 11.80361 ? 329  ALA A CB  1 
ATOM   2679 N  N   . ASP A 1 330 ? -11.73613 45.34163 -6.16922  1.000 15.08778 ? 330  ASP A N   1 
ATOM   2680 C  CA  . ASP A 1 330 ? -11.34654 46.56459 -5.48446  1.000 15.68184 ? 330  ASP A CA  1 
ATOM   2681 C  C   . ASP A 1 330 ? -10.32302 47.31334 -6.32958  1.000 14.16204 ? 330  ASP A C   1 
ATOM   2682 O  O   . ASP A 1 330 ? -9.34653  46.72133 -6.79891  1.000 15.96046 ? 330  ASP A O   1 
ATOM   2683 C  CB  . ASP A 1 330 ? -10.74286 46.24979 -4.11124  1.000 15.95176 ? 330  ASP A CB  1 
ATOM   2684 C  CG  . ASP A 1 330 ? -11.67618 45.44962 -3.21000  1.000 18.51556 ? 330  ASP A CG  1 
ATOM   2685 O  OD1 . ASP A 1 330 ? -12.90683 45.45535 -3.43145  1.000 18.56012 ? 330  ASP A OD1 1 
ATOM   2686 O  OD2 . ASP A 1 330 ? -11.16614 44.80474 -2.26338  1.000 19.99942 ? 330  ASP A OD2 1 
ATOM   2687 N  N   . VAL A 1 331 ? -10.53661 48.61571 -6.51999  1.000 16.35071 ? 331  VAL A N   1 
ATOM   2688 C  CA  . VAL A 1 331 ? -9.61348  49.45297 -7.28212  1.000 11.26728 ? 331  VAL A CA  1 
ATOM   2689 C  C   . VAL A 1 331 ? -8.77262  50.25719 -6.30052  1.000 18.51474 ? 331  VAL A C   1 
ATOM   2690 O  O   . VAL A 1 331 ? -9.31208  50.99726 -5.46871  1.000 17.27641 ? 331  VAL A O   1 
ATOM   2691 C  CB  . VAL A 1 331 ? -10.34731 50.38203 -8.26214  1.000 14.41264 ? 331  VAL A CB  1 
ATOM   2692 C  CG1 . VAL A 1 331 ? -9.34031  51.09540 -9.14756  1.000 12.85989 ? 331  VAL A CG1 1 
ATOM   2693 C  CG2 . VAL A 1 331 ? -11.30366 49.59619 -9.12165  1.000 16.19529 ? 331  VAL A CG2 1 
ATOM   2694 N  N   . TYR A 1 332 ? -7.45486  50.11733 -6.41512  1.000 14.01170 ? 332  TYR A N   1 
ATOM   2695 C  CA  . TYR A 1 332 ? -6.48477  50.80236 -5.57160  1.000 16.05457 ? 332  TYR A CA  1 
ATOM   2696 C  C   . TYR A 1 332 ? -5.93393  52.02598 -6.29723  1.000 17.80705 ? 332  TYR A C   1 
ATOM   2697 O  O   . TYR A 1 332 ? -5.57213  51.94464 -7.47760  1.000 16.03885 ? 332  TYR A O   1 
ATOM   2698 C  CB  . TYR A 1 332 ? -5.33709  49.84977 -5.21295  1.000 14.07750 ? 332  TYR A CB  1 
ATOM   2699 C  CG  . TYR A 1 332 ? -5.74320  48.71749 -4.29060  1.000 17.15928 ? 332  TYR A CG  1 
ATOM   2700 C  CD1 . TYR A 1 332 ? -6.65038  47.73856 -4.70063  1.000 15.60240 ? 332  TYR A CD1 1 
ATOM   2701 C  CD2 . TYR A 1 332 ? -5.22578  48.63083 -3.00322  1.000 23.30789 ? 332  TYR A CD2 1 
ATOM   2702 C  CE1 . TYR A 1 332 ? -7.03318  46.70679 -3.84431  1.000 17.66377 ? 332  TYR A CE1 1 
ATOM   2703 C  CE2 . TYR A 1 332 ? -5.59608  47.60281 -2.14359  1.000 24.04372 ? 332  TYR A CE2 1 
ATOM   2704 C  CZ  . TYR A 1 332 ? -6.49776  46.64697 -2.56848  1.000 21.63391 ? 332  TYR A CZ  1 
ATOM   2705 O  OH  . TYR A 1 332 ? -6.85564  45.63409 -1.70764  1.000 19.25233 ? 332  TYR A OH  1 
ATOM   2706 N  N   . TYR A 1 333 ? -5.85794  53.15639 -5.58452  1.000 20.01348 ? 333  TYR A N   1 
ATOM   2707 C  CA  . TYR A 1 333 ? -5.40096  54.42214 -6.15661  1.000 20.41845 ? 333  TYR A CA  1 
ATOM   2708 C  C   . TYR A 1 333 ? -4.23972  54.97473 -5.34664  1.000 21.86412 ? 333  TYR A C   1 
ATOM   2709 O  O   . TYR A 1 333 ? -4.30962  55.02478 -4.11247  1.000 22.96234 ? 333  TYR A O   1 
ATOM   2710 C  CB  . TYR A 1 333 ? -6.52637  55.46471 -6.18898  1.000 21.53611 ? 333  TYR A CB  1 
ATOM   2711 C  CG  . TYR A 1 333 ? -7.62471  55.14454 -7.17298  1.000 22.26107 ? 333  TYR A CG  1 
ATOM   2712 C  CD1 . TYR A 1 333 ? -7.49477  55.47567 -8.51462  1.000 26.30091 ? 333  TYR A CD1 1 
ATOM   2713 C  CD2 . TYR A 1 333 ? -8.78498  54.50478 -6.76338  1.000 23.25931 ? 333  TYR A CD2 1 
ATOM   2714 C  CE1 . TYR A 1 333 ? -8.49518  55.18418 -9.42827  1.000 23.74326 ? 333  TYR A CE1 1 
ATOM   2715 C  CE2 . TYR A 1 333 ? -9.79077  54.21212 -7.66428  1.000 24.08805 ? 333  TYR A CE2 1 
ATOM   2716 C  CZ  . TYR A 1 333 ? -9.63800  54.55291 -8.99825  1.000 31.19315 ? 333  TYR A CZ  1 
ATOM   2717 O  OH  . TYR A 1 333 ? -10.63052 54.25720 -9.91023  1.000 25.68682 ? 333  TYR A OH  1 
ATOM   2718 N  N   . ASP A 1 334 ? -3.18798  55.40445 -6.03902  1.000 20.60313 ? 334  ASP A N   1 
ATOM   2719 C  CA  . ASP A 1 334 ? -2.07118  56.05505 -5.37242  1.000 23.65874 ? 334  ASP A CA  1 
ATOM   2720 C  C   . ASP A 1 334 ? -2.42875  57.50692 -5.05033  1.000 30.26255 ? 334  ASP A C   1 
ATOM   2721 O  O   . ASP A 1 334 ? -3.53682  57.98369 -5.33241  1.000 31.84893 ? 334  ASP A O   1 
ATOM   2722 C  CB  . ASP A 1 334 ? -0.79504  55.93528 -6.21257  1.000 22.68650 ? 334  ASP A CB  1 
ATOM   2723 C  CG  . ASP A 1 334 ? -0.83250  56.74758 -7.51211  1.000 28.05911 ? 334  ASP A CG  1 
ATOM   2724 O  OD1 . ASP A 1 334 ? -1.66776  57.65558 -7.67903  1.000 27.36330 ? 334  ASP A OD1 1 
ATOM   2725 O  OD2 . ASP A 1 334 ? 0.01431   56.47274 -8.38231  1.000 29.88826 ? 334  ASP A OD2 1 
ATOM   2726 N  N   . ALA A 1 335 ? -1.47178  58.21783 -4.44387  1.000 28.66883 ? 335  ALA A N   1 
ATOM   2727 C  CA  . ALA A 1 335 ? -1.70076  59.59154 -4.01247  1.000 26.64995 ? 335  ALA A CA  1 
ATOM   2728 C  C   . ALA A 1 335 ? -1.99581  60.53672 -5.17464  1.000 30.81792 ? 335  ALA A C   1 
ATOM   2729 O  O   . ALA A 1 335 ? -2.64137  61.56635 -4.96535  1.000 36.13208 ? 335  ALA A O   1 
ATOM   2730 C  CB  . ALA A 1 335 ? -0.48876  60.09963 -3.22410  1.000 30.05919 ? 335  ALA A CB  1 
ATOM   2731 N  N   . ASN A 1 336 ? -1.54676  60.22232 -6.38670  1.000 31.68561 ? 336  ASN A N   1 
ATOM   2732 C  CA  . ASN A 1 336 ? -1.86318  61.03959 -7.54997  1.000 28.89470 ? 336  ASN A CA  1 
ATOM   2733 C  C   . ASN A 1 336 ? -3.16387  60.64046 -8.23761  1.000 38.86871 ? 336  ASN A C   1 
ATOM   2734 O  O   . ASN A 1 336 ? -3.49761  61.22265 -9.27317  1.000 36.51665 ? 336  ASN A O   1 
ATOM   2735 C  CB  . ASN A 1 336 ? -0.72552  60.97242 -8.56256  1.000 32.14037 ? 336  ASN A CB  1 
ATOM   2736 C  CG  . ASN A 1 336 ? 0.55938   61.53456 -8.01524  1.000 35.14280 ? 336  ASN A CG  1 
ATOM   2737 O  OD1 . ASN A 1 336 ? 0.54035   62.46066 -7.21282  1.000 39.79918 ? 336  ASN A OD1 1 
ATOM   2738 N  ND2 . ASN A 1 336 ? 1.68411   60.96645 -8.42976  1.000 43.92592 ? 336  ASN A ND2 1 
ATOM   2739 N  N   . GLY A 1 337 ? -3.89679  59.66390 -7.70714  1.000 30.50366 ? 337  GLY A N   1 
ATOM   2740 C  CA  . GLY A 1 337 ? -5.11669  59.22004 -8.35080  1.000 28.78210 ? 337  GLY A CA  1 
ATOM   2741 C  C   . GLY A 1 337 ? -4.92982  58.24701 -9.49396  1.000 28.88169 ? 337  GLY A C   1 
ATOM   2742 O  O   . GLY A 1 337 ? -5.88456  58.00949 -10.24427 1.000 31.89680 ? 337  GLY A O   1 
ATOM   2743 N  N   . ASN A 1 338 ? -3.73832  57.67920 -9.65784  1.000 22.82933 ? 338  ASN A N   1 
ATOM   2744 C  CA  . ASN A 1 338 ? -3.50560  56.66612 -10.67566 1.000 24.19081 ? 338  ASN A CA  1 
ATOM   2745 C  C   . ASN A 1 338 ? -3.82569  55.27921 -10.12436 1.000 28.57677 ? 338  ASN A C   1 
ATOM   2746 O  O   . ASN A 1 338 ? -3.64066  54.99936 -8.93291  1.000 22.12868 ? 338  ASN A O   1 
ATOM   2747 C  CB  . ASN A 1 338 ? -2.05904  56.71548 -11.17072 1.000 31.22579 ? 338  ASN A CB  1 
ATOM   2748 C  CG  . ASN A 1 338 ? -1.71912  58.03913 -11.83396 1.000 34.36887 ? 338  ASN A CG  1 
ATOM   2749 O  OD1 . ASN A 1 338 ? -2.58801  58.88432 -12.03029 1.000 42.37221 ? 338  ASN A OD1 1 
ATOM   2750 N  ND2 . ASN A 1 338 ? -0.45873  58.22139 -12.18345 1.000 38.98176 ? 338  ASN A ND2 1 
ATOM   2751 N  N   . VAL A 1 339 ? -4.32407  54.41062 -11.00416 1.000 22.83094 ? 339  VAL A N   1 
ATOM   2752 C  CA  . VAL A 1 339 ? -4.68175  53.05918 -10.58780 1.000 21.81455 ? 339  VAL A CA  1 
ATOM   2753 C  C   . VAL A 1 339 ? -3.42571  52.28783 -10.21735 1.000 18.90447 ? 339  VAL A C   1 
ATOM   2754 O  O   . VAL A 1 339 ? -2.40476  52.36893 -10.90747 1.000 19.07362 ? 339  VAL A O   1 
ATOM   2755 C  CB  . VAL A 1 339 ? -5.46131  52.33680 -11.69726 1.000 19.24862 ? 339  VAL A CB  1 
ATOM   2756 C  CG1 . VAL A 1 339 ? -5.67101  50.87345 -11.32100 1.000 16.51167 ? 339  VAL A CG1 1 
ATOM   2757 C  CG2 . VAL A 1 339 ? -6.81333  53.00814 -11.89673 1.000 21.05639 ? 339  VAL A CG2 1 
ATOM   2758 N  N   . VAL A 1 340 ? -3.49386  51.52899 -9.12382  1.000 18.02885 ? 340  VAL A N   1 
ATOM   2759 C  CA  . VAL A 1 340 ? -2.41815  50.62672 -8.71907  1.000 19.03674 ? 340  VAL A CA  1 
ATOM   2760 C  C   . VAL A 1 340 ? -2.92837  49.19440 -8.82344  1.000 19.61906 ? 340  VAL A C   1 
ATOM   2761 O  O   . VAL A 1 340 ? -3.90898  48.82813 -8.16538  1.000 16.30554 ? 340  VAL A O   1 
ATOM   2762 C  CB  . VAL A 1 340 ? -1.92342  50.93383 -7.29583  1.000 23.46765 ? 340  VAL A CB  1 
ATOM   2763 C  CG1 . VAL A 1 340 ? -0.84459  49.93083 -6.87264  1.000 18.45075 ? 340  VAL A CG1 1 
ATOM   2764 C  CG2 . VAL A 1 340 ? -1.38449  52.34469 -7.22348  1.000 21.05984 ? 340  VAL A CG2 1 
ATOM   2765 N  N   . VAL A 1 341 ? -2.27385  48.38839 -9.65806  1.000 19.62197 ? 341  VAL A N   1 
ATOM   2766 C  CA  . VAL A 1 341 ? -2.59246  46.96803 -9.77484  1.000 20.01545 ? 341  VAL A CA  1 
ATOM   2767 C  C   . VAL A 1 341 ? -1.45069  46.06813 -9.31736  1.000 24.09261 ? 341  VAL A C   1 
ATOM   2768 O  O   . VAL A 1 341 ? -1.67742  44.86172 -9.12998  1.000 18.64445 ? 341  VAL A O   1 
ATOM   2769 C  CB  . VAL A 1 341 ? -3.01576  46.58935 -11.21175 1.000 20.54778 ? 341  VAL A CB  1 
ATOM   2770 C  CG1 . VAL A 1 341 ? -4.23419  47.40846 -11.64322 1.000 22.88454 ? 341  VAL A CG1 1 
ATOM   2771 C  CG2 . VAL A 1 341 ? -1.86703  46.76624 -12.18303 1.000 24.23755 ? 341  VAL A CG2 1 
ATOM   2772 N  N   . ASP A 1 342 ? -0.24385  46.60515 -9.12889  1.000 22.82567 ? 342  ASP A N   1 
ATOM   2773 C  CA  . ASP A 1 342 ? 0.86617   45.85246 -8.54593  1.000 26.01374 ? 342  ASP A CA  1 
ATOM   2774 C  C   . ASP A 1 342 ? 0.52803   45.46506 -7.10438  1.000 25.58885 ? 342  ASP A C   1 
ATOM   2775 O  O   . ASP A 1 342 ? 0.31068   46.35191 -6.26460  1.000 23.46797 ? 342  ASP A O   1 
ATOM   2776 C  CB  . ASP A 1 342 ? 2.14173   46.70314 -8.61035  1.000 27.08023 ? 342  ASP A CB  1 
ATOM   2777 C  CG  . ASP A 1 342 ? 3.38150   46.00190 -8.03399  1.000 35.11944 ? 342  ASP A CG  1 
ATOM   2778 O  OD1 . ASP A 1 342 ? 3.25954   45.05326 -7.22586  1.000 42.71606 ? 342  ASP A OD1 1 
ATOM   2779 O  OD2 . ASP A 1 342 ? 4.50755   46.43334 -8.37672  1.000 43.15419 ? 342  ASP A OD2 1 
ATOM   2780 N  N   . PRO A 1 343 ? 0.50496   44.17255 -6.76715  1.000 25.51008 ? 343  PRO A N   1 
ATOM   2781 C  CA  . PRO A 1 343 ? -0.00299  43.75658 -5.44520  1.000 29.67254 ? 343  PRO A CA  1 
ATOM   2782 C  C   . PRO A 1 343 ? 0.82665   44.22029 -4.24626  1.000 28.93371 ? 343  PRO A C   1 
ATOM   2783 O  O   . PRO A 1 343 ? 0.32262   44.15452 -3.11720  1.000 33.02535 ? 343  PRO A O   1 
ATOM   2784 C  CB  . PRO A 1 343 ? -0.02726  42.22147 -5.53897  1.000 31.14577 ? 343  PRO A CB  1 
ATOM   2785 C  CG  . PRO A 1 343 ? 0.80761   41.87677 -6.72154  1.000 40.09498 ? 343  PRO A CG  1 
ATOM   2786 C  CD  . PRO A 1 343 ? 0.73394   43.03305 -7.66755  1.000 30.17915 ? 343  PRO A CD  1 
ATOM   2787 N  N   . ASN A 1 344 ? 2.05521   44.68882 -4.42093  1.000 28.68287 ? 344  ASN A N   1 
ATOM   2788 C  CA  . ASN A 1 344 ? 2.81322   45.17933 -3.27327  1.000 39.69047 ? 344  ASN A CA  1 
ATOM   2789 C  C   . ASN A 1 344 ? 3.07819   46.67537 -3.31054  1.000 38.91128 ? 344  ASN A C   1 
ATOM   2790 O  O   . ASN A 1 344 ? 3.72872   47.19526 -2.39401  1.000 40.38635 ? 344  ASN A O   1 
ATOM   2791 C  CB  . ASN A 1 344 ? 4.15010   44.43225 -3.13930  1.000 40.87817 ? 344  ASN A CB  1 
ATOM   2792 C  CG  . ASN A 1 344 ? 3.97604   42.92453 -3.13200  1.000 47.15202 ? 344  ASN A CG  1 
ATOM   2793 O  OD1 . ASN A 1 344 ? 3.47842   42.35229 -2.15704  1.000 48.87872 ? 344  ASN A OD1 1 
ATOM   2794 N  ND2 . ASN A 1 344 ? 4.38513   42.27089 -4.21740  1.000 45.10747 ? 344  ASN A ND2 1 
ATOM   2795 N  N   . ALA A 1 345 ? 2.56043   47.38449 -4.30488  1.000 30.92863 ? 345  ALA A N   1 
ATOM   2796 C  CA  . ALA A 1 345 ? 2.93496   48.76491 -4.53452  1.000 24.62280 ? 345  ALA A CA  1 
ATOM   2797 C  C   . ALA A 1 345 ? 2.26746   49.71309 -3.54272  1.000 20.27672 ? 345  ALA A C   1 
ATOM   2798 O  O   . ALA A 1 345 ? 1.20303   49.41886 -2.98527  1.000 18.59836 ? 345  ALA A O   1 
ATOM   2799 C  CB  . ALA A 1 345 ? 2.57654   49.17028 -5.96077  1.000 27.61385 ? 345  ALA A CB  1 
ATOM   2800 N  N   . PRO A 1 346 ? 2.88782   50.86793 -3.30842  1.000 22.74070 ? 346  PRO A N   1 
ATOM   2801 C  CA  . PRO A 1 346 ? 2.23906   51.91154 -2.51089  1.000 22.85163 ? 346  PRO A CA  1 
ATOM   2802 C  C   . PRO A 1 346 ? 0.88267   52.29493 -3.08061  1.000 24.96744 ? 346  PRO A C   1 
ATOM   2803 O  O   . PRO A 1 346 ? 0.65234   52.25245 -4.29434  1.000 19.80470 ? 346  PRO A O   1 
ATOM   2804 C  CB  . PRO A 1 346 ? 3.21843   53.08797 -2.59903  1.000 21.89640 ? 346  PRO A CB  1 
ATOM   2805 C  CG  . PRO A 1 346 ? 4.51249   52.49333 -3.00136  1.000 22.41042 ? 346  PRO A CG  1 
ATOM   2806 C  CD  . PRO A 1 346 ? 4.22332   51.26780 -3.79010  1.000 23.50914 ? 346  PRO A CD  1 
ATOM   2807 N  N   . TYR A 1 347 ? -0.01537  52.68214 -2.18074  1.000 19.93671 ? 347  TYR A N   1 
ATOM   2808 C  CA  . TYR A 1 347 ? -1.30969  53.21195 -2.57324  1.000 21.96396 ? 347  TYR A CA  1 
ATOM   2809 C  C   . TYR A 1 347 ? -1.88586  53.98818 -1.39712  1.000 24.94833 ? 347  TYR A C   1 
ATOM   2810 O  O   . TYR A 1 347 ? -1.46277  53.81257 -0.24959  1.000 22.93895 ? 347  TYR A O   1 
ATOM   2811 C  CB  . TYR A 1 347 ? -2.24993  52.09248 -3.02843  1.000 22.12120 ? 347  TYR A CB  1 
ATOM   2812 C  CG  . TYR A 1 347 ? -2.90903  51.32213 -1.90354  1.000 21.47128 ? 347  TYR A CG  1 
ATOM   2813 C  CD1 . TYR A 1 347 ? -2.28678  50.22236 -1.31714  1.000 22.14663 ? 347  TYR A CD1 1 
ATOM   2814 C  CD2 . TYR A 1 347 ? -4.16632  51.68740 -1.44154  1.000 21.55041 ? 347  TYR A CD2 1 
ATOM   2815 C  CE1 . TYR A 1 347 ? -2.91763  49.51025 -0.27971  1.000 20.36318 ? 347  TYR A CE1 1 
ATOM   2816 C  CE2 . TYR A 1 347 ? -4.78828  50.99372 -0.42258  1.000 23.07565 ? 347  TYR A CE2 1 
ATOM   2817 C  CZ  . TYR A 1 347 ? -4.16397  49.91186 0.15025   1.000 20.94872 ? 347  TYR A CZ  1 
ATOM   2818 O  OH  . TYR A 1 347 ? -4.81557  49.24563 1.16534   1.000 28.32757 ? 347  TYR A OH  1 
ATOM   2819 N  N   . ALA A 1 348 ? -2.86115  54.84883 -1.70283  1.000 17.35293 ? 348  ALA A N   1 
ATOM   2820 C  CA  . ALA A 1 348 ? -3.47289  55.76053 -0.74495  1.000 21.39908 ? 348  ALA A CA  1 
ATOM   2821 C  C   . ALA A 1 348 ? -4.88791  55.38302 -0.34710  1.000 26.42480 ? 348  ALA A C   1 
ATOM   2822 O  O   . ALA A 1 348 ? -5.23405  55.47183 0.83456   1.000 24.70586 ? 348  ALA A O   1 
ATOM   2823 C  CB  . ALA A 1 348 ? -3.49002  57.18285 -1.31533  1.000 26.03466 ? 348  ALA A CB  1 
ATOM   2824 N  N   . LYS A 1 349 ? -5.73596  55.00040 -1.30348  1.000 23.63831 ? 349  LYS A N   1 
ATOM   2825 C  CA  . LYS A 1 349 ? -7.11339  54.64780 -1.00583  1.000 26.37511 ? 349  LYS A CA  1 
ATOM   2826 C  C   . LYS A 1 349 ? -7.52063  53.46995 -1.87246  1.000 24.07723 ? 349  LYS A C   1 
ATOM   2827 O  O   . LYS A 1 349 ? -6.84326  53.10900 -2.83675  1.000 21.57954 ? 349  LYS A O   1 
ATOM   2828 C  CB  . LYS A 1 349 ? -8.07533  55.82886 -1.21957  1.000 25.39760 ? 349  LYS A CB  1 
ATOM   2829 C  CG  . LYS A 1 349 ? -8.04978  56.41265 -2.62169  1.000 33.66087 ? 349  LYS A CG  1 
ATOM   2830 C  CD  . LYS A 1 349 ? -9.09685  57.51657 -2.79849  1.000 42.13086 ? 349  LYS A CD  1 
ATOM   2831 C  CE  . LYS A 1 349 ? -10.31218 57.01132 -3.57592  1.000 48.99039 ? 349  LYS A CE  1 
ATOM   2832 N  NZ  . LYS A 1 349 ? -11.45497 57.97058 -3.59392  1.000 55.47341 ? 349  LYS A NZ  1 
ATOM   2833 N  N   . VAL A 1 350 ? -8.63954  52.86350 -1.51041  1.000 24.98592 ? 350  VAL A N   1 
ATOM   2834 C  CA  . VAL A 1 350 ? -9.19492  51.74779 -2.26159  1.000 28.25565 ? 350  VAL A CA  1 
ATOM   2835 C  C   . VAL A 1 350 ? -10.68689 52.00163 -2.43077  1.000 22.96174 ? 350  VAL A C   1 
ATOM   2836 O  O   . VAL A 1 350 ? -11.33591 52.55111 -1.53281  1.000 25.86531 ? 350  VAL A O   1 
ATOM   2837 C  CB  . VAL A 1 350 ? -8.90400  50.39336 -1.56432  1.000 23.93027 ? 350  VAL A CB  1 
ATOM   2838 C  CG1 . VAL A 1 350 ? -9.58009  50.31770 -0.19255  1.000 25.74847 ? 350  VAL A CG1 1 
ATOM   2839 C  CG2 . VAL A 1 350 ? -9.34123  49.22992 -2.43565  1.000 23.35004 ? 350  VAL A CG2 1 
ATOM   2840 N  N   . GLU A 1 351 ? -11.21896 51.65878 -3.61002  1.000 23.13285 ? 351  GLU A N   1 
ATOM   2841 C  CA  . GLU A 1 351 ? -12.65868 51.72621 -3.88221  1.000 22.42432 ? 351  GLU A CA  1 
ATOM   2842 C  C   . GLU A 1 351 ? -13.16309 50.29405 -4.01606  1.000 23.07467 ? 351  GLU A C   1 
ATOM   2843 O  O   . GLU A 1 351 ? -12.98003 49.64824 -5.05581  1.000 17.01932 ? 351  GLU A O   1 
ATOM   2844 C  CB  . GLU A 1 351 ? -12.94944 52.56032 -5.12582  1.000 25.46668 ? 351  GLU A CB  1 
ATOM   2845 C  CG  . GLU A 1 351 ? -12.81155 54.06013 -4.86619  1.000 29.92826 ? 351  GLU A CG  1 
ATOM   2846 C  CD  . GLU A 1 351 ? -12.96734 54.91030 -6.11835  1.000 41.83709 ? 351  GLU A CD  1 
ATOM   2847 O  OE1 . GLU A 1 351 ? -13.42279 54.38059 -7.15823  1.000 40.74922 ? 351  GLU A OE1 1 
ATOM   2848 O  OE2 . GLU A 1 351 ? -12.63281 56.11551 -6.05963  1.000 40.06628 ? 351  GLU A OE2 1 
ATOM   2849 N  N   . LYS A 1 352 ? -13.79589 49.80579 -2.95446  1.000 19.48648 ? 352  LYS A N   1 
ATOM   2850 C  CA  . LYS A 1 352 ? -14.11383 48.39113 -2.85686  1.000 23.28086 ? 352  LYS A CA  1 
ATOM   2851 C  C   . LYS A 1 352 ? -15.23932 48.03678 -3.81511  1.000 20.50021 ? 352  LYS A C   1 
ATOM   2852 O  O   . LYS A 1 352 ? -16.27059 48.71221 -3.84884  1.000 20.12074 ? 352  LYS A O   1 
ATOM   2853 C  CB  . LYS A 1 352 ? -14.49944 48.03746 -1.41914  1.000 26.77416 ? 352  LYS A CB  1 
ATOM   2854 C  CG  . LYS A 1 352 ? -13.31198 48.07662 -0.45188  1.000 29.85934 ? 352  LYS A CG  1 
ATOM   2855 C  CD  . LYS A 1 352 ? -13.45816 47.05617 0.68004   1.000 34.14378 ? 352  LYS A CD  1 
ATOM   2856 C  CE  . LYS A 1 352 ? -12.11135 46.73920 1.32770   1.000 43.59094 ? 352  LYS A CE  1 
ATOM   2857 N  NZ  . LYS A 1 352 ? -11.49856 47.92887 1.99386   1.000 48.39373 ? 352  LYS A NZ  1 
ATOM   2858 N  N   . GLY A 1 353 ? -15.03312 46.98077 -4.60213  1.000 16.71663 ? 353  GLY A N   1 
ATOM   2859 C  CA  . GLY A 1 353 ? -16.07505 46.50187 -5.49379  1.000 19.60883 ? 353  GLY A CA  1 
ATOM   2860 C  C   . GLY A 1 353 ? -16.44811 47.42967 -6.62944  1.000 22.61506 ? 353  GLY A C   1 
ATOM   2861 O  O   . GLY A 1 353 ? -17.55067 47.30837 -7.17230  1.000 20.54933 ? 353  GLY A O   1 
ATOM   2862 N  N   . LYS A 1 354 ? -15.55458 48.34296 -7.02737  1.000 17.17304 ? 354  LYS A N   1 
ATOM   2863 C  CA  . LYS A 1 354 ? -15.85063 49.30435 -8.08457  1.000 18.15771 ? 354  LYS A CA  1 
ATOM   2864 C  C   . LYS A 1 354 ? -15.20574 48.96927 -9.42338  1.000 20.49103 ? 354  LYS A C   1 
ATOM   2865 O  O   . LYS A 1 354 ? -15.49425 49.65037 -10.41301 1.000 16.41252 ? 354  LYS A O   1 
ATOM   2866 C  CB  . LYS A 1 354 ? -15.40531 50.71287 -7.66160  1.000 17.46082 ? 354  LYS A CB  1 
ATOM   2867 C  CG  . LYS A 1 354 ? -16.19823 51.26345 -6.48217  1.000 24.26186 ? 354  LYS A CG  1 
ATOM   2868 C  CD  . LYS A 1 354 ? -17.69477 51.12171 -6.73388  1.000 32.91771 ? 354  LYS A CD  1 
ATOM   2869 C  CE  . LYS A 1 354 ? -18.50083 52.12356 -5.92099  1.000 38.36458 ? 354  LYS A CE  1 
ATOM   2870 N  NZ  . LYS A 1 354 ? -18.35592 51.88982 -4.45964  1.000 54.58266 ? 354  LYS A NZ  1 
ATOM   2871 N  N   . GLY A 1 355 ? -14.34636 47.95605 -9.48500  1.000 14.57985 ? 355  GLY A N   1 
ATOM   2872 C  CA  . GLY A 1 355 ? -13.62246 47.62471 -10.69657 1.000 16.99498 ? 355  GLY A CA  1 
ATOM   2873 C  C   . GLY A 1 355 ? -14.32296 46.56605 -11.52511 1.000 17.53378 ? 355  GLY A C   1 
ATOM   2874 O  O   . GLY A 1 355 ? -15.50608 46.27463 -11.33724 1.000 17.59573 ? 355  GLY A O   1 
ATOM   2875 N  N   . LYS A 1 356 ? -13.56806 45.97432 -12.45252 1.000 13.46842 ? 356  LYS A N   1 
ATOM   2876 C  CA  . LYS A 1 356 ? -14.13216 45.05101 -13.43251 1.000 13.77110 ? 356  LYS A CA  1 
ATOM   2877 C  C   . LYS A 1 356 ? -13.20129 43.85935 -13.58508 1.000 14.95801 ? 356  LYS A C   1 
ATOM   2878 O  O   . LYS A 1 356 ? -12.01415 44.03076 -13.87486 1.000 13.53150 ? 356  LYS A O   1 
ATOM   2879 C  CB  . LYS A 1 356 ? -14.34664 45.74261 -14.78669 1.000 12.27662 ? 356  LYS A CB  1 
ATOM   2880 C  CG  . LYS A 1 356 ? -15.14400 44.92050 -15.80917 1.000 13.06144 ? 356  LYS A CG  1 
ATOM   2881 C  CD  . LYS A 1 356 ? -16.66049 44.97675 -15.52176 1.000 14.16065 ? 356  LYS A CD  1 
ATOM   2882 C  CE  . LYS A 1 356 ? -17.42387 43.79055 -16.14863 1.000 16.60885 ? 356  LYS A CE  1 
ATOM   2883 N  NZ  . LYS A 1 356 ? -17.18793 42.49182 -15.41454 1.000 13.81468 ? 356  LYS A NZ  1 
ATOM   2884 N  N   . ASP A 1 357 ? -13.74078 42.66131 -13.37771 1.000 13.38364 ? 357  ASP A N   1 
ATOM   2885 C  CA  . ASP A 1 357 ? -13.06825 41.40506 -13.67669 1.000 11.30480 ? 357  ASP A CA  1 
ATOM   2886 C  C   . ASP A 1 357 ? -13.59995 40.86018 -14.99868 1.000 12.63055 ? 357  ASP A C   1 
ATOM   2887 O  O   . ASP A 1 357 ? -14.57975 41.36235 -15.55531 1.000 12.05800 ? 357  ASP A O   1 
ATOM   2888 C  CB  . ASP A 1 357 ? -13.28184 40.38951 -12.54739 1.000 15.12254 ? 357  ASP A CB  1 
ATOM   2889 C  CG  . ASP A 1 357 ? -12.07291 39.48134 -12.33604 1.000 14.32697 ? 357  ASP A CG  1 
ATOM   2890 O  OD1 . ASP A 1 357 ? -11.36097 39.21281 -13.32964 1.000 12.07656 ? 357  ASP A OD1 1 
ATOM   2891 O  OD2 . ASP A 1 357 ? -11.83980 39.04329 -11.18069 1.000 13.33465 ? 357  ASP A OD2 1 
ATOM   2892 N  N   . ALA A 1 358 ? -12.94392 39.81726 -15.50820 1.000 11.39765 ? 358  ALA A N   1 
ATOM   2893 C  CA  . ALA A 1 358 ? -13.21043 39.31757 -16.86196 1.000 10.96388 ? 358  ALA A CA  1 
ATOM   2894 C  C   . ALA A 1 358 ? -12.98395 37.81126 -16.90341 1.000 13.86471 ? 358  ALA A C   1 
ATOM   2895 O  O   . ALA A 1 358 ? -12.02629 37.32101 -17.52123 1.000 11.51069 ? 358  ALA A O   1 
ATOM   2896 C  CB  . ALA A 1 358 ? -12.31941 40.03637 -17.87531 1.000 12.12906 ? 358  ALA A CB  1 
ATOM   2897 N  N   . PRO A 1 359 ? -13.88236 37.02749 -16.28075 1.000 9.17474  ? 359  PRO A N   1 
ATOM   2898 C  CA  . PRO A 1 359 ? -13.52451 35.64745 -15.90075 1.000 8.80674  ? 359  PRO A CA  1 
ATOM   2899 C  C   . PRO A 1 359 ? -13.93199 34.53861 -16.85851 1.000 13.22705 ? 359  PRO A C   1 
ATOM   2900 O  O   . PRO A 1 359 ? -13.54396 33.37978 -16.64247 1.000 11.24389 ? 359  PRO A O   1 
ATOM   2901 C  CB  . PRO A 1 359 ? -14.25015 35.48359 -14.56197 1.000 9.92083  ? 359  PRO A CB  1 
ATOM   2902 C  CG  . PRO A 1 359 ? -15.52440 36.28699 -14.75605 1.000 13.03411 ? 359  PRO A CG  1 
ATOM   2903 C  CD  . PRO A 1 359 ? -15.14524 37.46875 -15.64813 1.000 10.54131 ? 359  PRO A CD  1 
ATOM   2904 N  N   . PHE A 1 360 ? -14.69814 34.85633 -17.90711 1.000 11.07643 ? 360  PHE A N   1 
ATOM   2905 C  CA  . PHE A 1 360 ? -15.35607 33.84728 -18.73590 1.000 12.99416 ? 360  PHE A CA  1 
ATOM   2906 C  C   . PHE A 1 360 ? -14.65961 33.71191 -20.08905 1.000 10.10545 ? 360  PHE A C   1 
ATOM   2907 O  O   . PHE A 1 360 ? -13.64083 34.34935 -20.35510 1.000 12.93926 ? 360  PHE A O   1 
ATOM   2908 C  CB  . PHE A 1 360 ? -16.83585 34.20423 -18.90251 1.000 11.78535 ? 360  PHE A CB  1 
ATOM   2909 C  CG  . PHE A 1 360 ? -17.56048 34.32970 -17.60208 1.000 11.59112 ? 360  PHE A CG  1 
ATOM   2910 C  CD1 . PHE A 1 360 ? -17.47233 33.32664 -16.64645 1.000 10.80099 ? 360  PHE A CD1 1 
ATOM   2911 C  CD2 . PHE A 1 360 ? -18.32472 35.45479 -17.32333 1.000 12.10056 ? 360  PHE A CD2 1 
ATOM   2912 C  CE1 . PHE A 1 360 ? -18.15034 33.44090 -15.42315 1.000 9.97609  ? 360  PHE A CE1 1 
ATOM   2913 C  CE2 . PHE A 1 360 ? -19.00965 35.56853 -16.11160 1.000 12.37172 ? 360  PHE A CE2 1 
ATOM   2914 C  CZ  . PHE A 1 360 ? -18.90525 34.57080 -15.15631 1.000 11.96173 ? 360  PHE A CZ  1 
ATOM   2915 N  N   . VAL A 1 361 ? -15.20918 32.85427 -20.95729 1.000 11.75610 ? 361  VAL A N   1 
ATOM   2916 C  CA  . VAL A 1 361 ? -14.69276 32.73735 -22.31820 1.000 11.16966 ? 361  VAL A CA  1 
ATOM   2917 C  C   . VAL A 1 361 ? -15.46448 33.61312 -23.29908 1.000 10.21693 ? 361  VAL A C   1 
ATOM   2918 O  O   . VAL A 1 361 ? -15.11280 33.66275 -24.48318 1.000 11.63416 ? 361  VAL A O   1 
ATOM   2919 C  CB  . VAL A 1 361 ? -14.66558 31.26915 -22.80987 1.000 8.92838  ? 361  VAL A CB  1 
ATOM   2920 C  CG1 . VAL A 1 361 ? -13.91826 30.36383 -21.82163 1.000 9.99901  ? 361  VAL A CG1 1 
ATOM   2921 C  CG2 . VAL A 1 361 ? -16.07742 30.74054 -23.09004 1.000 7.79300  ? 361  VAL A CG2 1 
ATOM   2922 N  N   . PHE A 1 362 ? -16.49634 34.31286 -22.83656 1.000 10.17292 ? 362  PHE A N   1 
ATOM   2923 C  CA  . PHE A 1 362 ? -17.31125 35.19772 -23.65821 1.000 10.17664 ? 362  PHE A CA  1 
ATOM   2924 C  C   . PHE A 1 362 ? -17.19408 36.61945 -23.11805 1.000 11.57140 ? 362  PHE A C   1 
ATOM   2925 O  O   . PHE A 1 362 ? -17.36941 36.84654 -21.91600 1.000 10.09960 ? 362  PHE A O   1 
ATOM   2926 C  CB  . PHE A 1 362 ? -18.77891 34.74753 -23.65756 1.000 10.43759 ? 362  PHE A CB  1 
ATOM   2927 C  CG  . PHE A 1 362 ? -18.97546 33.32589 -24.11695 1.000 9.38496  ? 362  PHE A CG  1 
ATOM   2928 C  CD1 . PHE A 1 362 ? -18.61542 32.94135 -25.40091 1.000 11.94593 ? 362  PHE A CD1 1 
ATOM   2929 C  CD2 . PHE A 1 362 ? -19.53062 32.37548 -23.26858 1.000 12.43912 ? 362  PHE A CD2 1 
ATOM   2930 C  CE1 . PHE A 1 362 ? -18.80026 31.62421 -25.83429 1.000 12.97586 ? 362  PHE A CE1 1 
ATOM   2931 C  CE2 . PHE A 1 362 ? -19.71811 31.06946 -23.69746 1.000 12.35703 ? 362  PHE A CE2 1 
ATOM   2932 C  CZ  . PHE A 1 362 ? -19.34412 30.69541 -24.98410 1.000 9.31851  ? 362  PHE A CZ  1 
ATOM   2933 N  N   . GLY A 1 363 ? -16.88673 37.56099 -23.99771 1.000 13.24942 ? 363  GLY A N   1 
ATOM   2934 C  CA  . GLY A 1 363 ? -16.69631 38.94327 -23.60440 1.000 11.71198 ? 363  GLY A CA  1 
ATOM   2935 C  C   . GLY A 1 363 ? -18.01027 39.63967 -23.30817 1.000 11.86498 ? 363  GLY A C   1 
ATOM   2936 O  O   . GLY A 1 363 ? -19.11024 39.12400 -23.55772 1.000 12.17071 ? 363  GLY A O   1 
ATOM   2937 N  N   . PRO A 1 364 ? -17.90725 40.86662 -22.78634 1.000 12.74338 ? 364  PRO A N   1 
ATOM   2938 C  CA  . PRO A 1 364 ? -19.11639 41.57251 -22.32765 1.000 10.57059 ? 364  PRO A CA  1 
ATOM   2939 C  C   . PRO A 1 364 ? -20.02687 41.99748 -23.44959 1.000 12.94294 ? 364  PRO A C   1 
ATOM   2940 O  O   . PRO A 1 364 ? -21.18524 42.34472 -23.17916 1.000 14.11068 ? 364  PRO A O   1 
ATOM   2941 C  CB  . PRO A 1 364 ? -18.55603 42.79265 -21.58518 1.000 14.36162 ? 364  PRO A CB  1 
ATOM   2942 C  CG  . PRO A 1 364 ? -17.21382 43.03907 -22.23632 1.000 18.27582 ? 364  PRO A CG  1 
ATOM   2943 C  CD  . PRO A 1 364 ? -16.68787 41.68893 -22.67512 1.000 15.37436 ? 364  PRO A CD  1 
ATOM   2944 N  N   . ASP A 1 365 ? -19.53344 41.99691 -24.68809 1.000 12.02737 ? 365  ASP A N   1 
ATOM   2945 C  CA  . ASP A 1 365 ? -20.33397 42.23756 -25.87640 1.000 13.87405 ? 365  ASP A CA  1 
ATOM   2946 C  C   . ASP A 1 365 ? -20.76511 40.93595 -26.53515 1.000 13.03976 ? 365  ASP A C   1 
ATOM   2947 O  O   . ASP A 1 365 ? -21.16121 40.93741 -27.70606 1.000 10.11761 ? 365  ASP A O   1 
ATOM   2948 C  CB  . ASP A 1 365 ? -19.56092 43.11974 -26.86350 1.000 14.25170 ? 365  ASP A CB  1 
ATOM   2949 C  CG  . ASP A 1 365 ? -18.17357 42.56425 -27.21628 1.000 15.91352 ? 365  ASP A CG  1 
ATOM   2950 O  OD1 . ASP A 1 365 ? -17.81040 41.45013 -26.77193 1.000 12.53659 ? 365  ASP A OD1 1 
ATOM   2951 O  OD2 . ASP A 1 365 ? -17.43106 43.25776 -27.95320 1.000 12.63268 ? 365  ASP A OD2 1 
ATOM   2952 N  N   . TYR A 1 366 ? -20.67282 39.82279 -25.80274 1.000 11.07889 ? 366  TYR A N   1 
ATOM   2953 C  CA  . TYR A 1 366 ? -21.11641 38.51206 -26.27800 1.000 12.12922 ? 366  TYR A CA  1 
ATOM   2954 C  C   . TYR A 1 366 ? -20.33422 38.04291 -27.50589 1.000 12.45896 ? 366  TYR A C   1 
ATOM   2955 O  O   . TYR A 1 366 ? -20.85393 37.29696 -28.33989 1.000 14.29163 ? 366  TYR A O   1 
ATOM   2956 C  CB  . TYR A 1 366 ? -22.62631 38.51424 -26.54835 1.000 12.19720 ? 366  TYR A CB  1 
ATOM   2957 C  CG  . TYR A 1 366 ? -23.42371 38.70223 -25.27936 1.000 13.25548 ? 366  TYR A CG  1 
ATOM   2958 C  CD1 . TYR A 1 366 ? -23.79047 37.60829 -24.49770 1.000 12.89487 ? 366  TYR A CD1 1 
ATOM   2959 C  CD2 . TYR A 1 366 ? -23.79537 39.97016 -24.84927 1.000 13.22022 ? 366  TYR A CD2 1 
ATOM   2960 C  CE1 . TYR A 1 366 ? -24.50523 37.77348 -23.31497 1.000 11.94578 ? 366  TYR A CE1 1 
ATOM   2961 C  CE2 . TYR A 1 366 ? -24.51340 40.14665 -23.66876 1.000 12.91213 ? 366  TYR A CE2 1 
ATOM   2962 C  CZ  . TYR A 1 366 ? -24.86577 39.04930 -22.90554 1.000 15.11718 ? 366  TYR A CZ  1 
ATOM   2963 O  OH  . TYR A 1 366 ? -25.57877 39.22310 -21.73148 1.000 11.77653 ? 366  TYR A OH  1 
ATOM   2964 N  N   . LYS A 1 367 ? -19.08151 38.47686 -27.63011 1.000 14.77797 ? 367  LYS A N   1 
ATOM   2965 C  CA  . LYS A 1 367 ? -18.15663 37.95418 -28.62793 1.000 12.10397 ? 367  LYS A CA  1 
ATOM   2966 C  C   . LYS A 1 367 ? -17.11136 37.08450 -27.93424 1.000 11.57369 ? 367  LYS A C   1 
ATOM   2967 O  O   . LYS A 1 367 ? -16.81848 37.27141 -26.75011 1.000 14.41684 ? 367  LYS A O   1 
ATOM   2968 C  CB  . LYS A 1 367 ? -17.49323 39.09594 -29.41420 1.000 13.62490 ? 367  LYS A CB  1 
ATOM   2969 C  CG  . LYS A 1 367 ? -18.48518 39.90634 -30.25710 1.000 15.00521 ? 367  LYS A CG  1 
ATOM   2970 C  CD  . LYS A 1 367 ? -17.88284 41.21485 -30.78339 1.000 15.15378 ? 367  LYS A CD  1 
ATOM   2971 C  CE  . LYS A 1 367 ? -18.94047 42.07864 -31.49413 1.000 17.87108 ? 367  LYS A CE  1 
ATOM   2972 N  NZ  . LYS A 1 367 ? -18.45192 43.48518 -31.65406 1.000 17.83242 ? 367  LYS A NZ  1 
ATOM   2973 N  N   . VAL A 1 368 ? -16.56390 36.10741 -28.66512 1.000 11.86055 ? 368  VAL A N   1 
ATOM   2974 C  CA  . VAL A 1 368 ? -15.70807 35.09900 -28.04310 1.000 13.17079 ? 368  VAL A CA  1 
ATOM   2975 C  C   . VAL A 1 368 ? -14.33301 35.68927 -27.74992 1.000 13.68563 ? 368  VAL A C   1 
ATOM   2976 O  O   . VAL A 1 368 ? -13.80376 36.50971 -28.50970 1.000 11.69429 ? 368  VAL A O   1 
ATOM   2977 C  CB  . VAL A 1 368 ? -15.60686 33.83658 -28.92775 1.000 12.67923 ? 368  VAL A CB  1 
ATOM   2978 C  CG1 . VAL A 1 368 ? -16.99520 33.18518 -29.10164 1.000 12.84846 ? 368  VAL A CG1 1 
ATOM   2979 C  CG2 . VAL A 1 368 ? -14.96974 34.16176 -30.29529 1.000 11.47745 ? 368  VAL A CG2 1 
ATOM   2980 N  N   . LYS A 1 369 ? -13.75098 35.26327 -26.64655 1.000 13.12800 ? 369  LYS A N   1 
ATOM   2981 C  CA  . LYS A 1 369 ? -12.43841 35.68905 -26.19467 1.000 12.06171 ? 369  LYS A CA  1 
ATOM   2982 C  C   . LYS A 1 369 ? -11.38765 34.68114 -26.63467 1.000 11.85635 ? 369  LYS A C   1 
ATOM   2983 O  O   . LYS A 1 369 ? -11.71252 33.59228 -27.12098 1.000 12.61849 ? 369  LYS A O   1 
ATOM   2984 C  CB  . LYS A 1 369 ? -12.45070 35.83634 -24.66664 1.000 12.42703 ? 369  LYS A CB  1 
ATOM   2985 C  CG  . LYS A 1 369 ? -13.42328 36.90737 -24.18916 1.000 9.79935  ? 369  LYS A CG  1 
ATOM   2986 C  CD  . LYS A 1 369 ? -13.67160 36.82694 -22.67468 1.000 9.54713  ? 369  LYS A CD  1 
ATOM   2987 C  CE  . LYS A 1 369 ? -12.37770 36.90541 -21.85581 1.000 10.90525 ? 369  LYS A CE  1 
ATOM   2988 N  NZ  . LYS A 1 369 ? -12.70544 36.84005 -20.37828 1.000 11.31376 ? 369  LYS A NZ  1 
ATOM   2989 N  N   . PRO A 1 370 ? -10.10564 35.01452 -26.51278 1.000 12.03947 ? 370  PRO A N   1 
ATOM   2990 C  CA  . PRO A 1 370 ? -9.08901  33.99595 -26.80613 1.000 15.10860 ? 370  PRO A CA  1 
ATOM   2991 C  C   . PRO A 1 370 ? -9.28486  32.74453 -25.97651 1.000 12.88827 ? 370  PRO A C   1 
ATOM   2992 O  O   . PRO A 1 370 ? -9.00037  31.64412 -26.46075 1.000 13.10549 ? 370  PRO A O   1 
ATOM   2993 C  CB  . PRO A 1 370 ? -7.76758  34.70823 -26.48075 1.000 9.99540  ? 370  PRO A CB  1 
ATOM   2994 C  CG  . PRO A 1 370 ? -8.06820  36.15620 -26.70149 1.000 16.37693 ? 370  PRO A CG  1 
ATOM   2995 C  CD  . PRO A 1 370 ? -9.51097  36.35004 -26.29146 1.000 13.88438 ? 370  PRO A CD  1 
ATOM   2996 N  N   . ALA A 1 371 ? -9.78443  32.87898 -24.74171 1.000 11.92393 ? 371  ALA A N   1 
ATOM   2997 C  CA  . ALA A 1 371 ? -10.02365 31.70823 -23.90098 1.000 11.34228 ? 371  ALA A CA  1 
ATOM   2998 C  C   . ALA A 1 371 ? -11.03848 30.74900 -24.51589 1.000 14.33494 ? 371  ALA A C   1 
ATOM   2999 O  O   . ALA A 1 371 ? -10.92332 29.53024 -24.32612 1.000 11.06588 ? 371  ALA A O   1 
ATOM   3000 C  CB  . ALA A 1 371 ? -10.48820 32.13544 -22.50524 1.000 9.96722  ? 371  ALA A CB  1 
ATOM   3001 N  N   . TYR A 1 372 ? -12.04115 31.27048 -25.23136 1.000 10.61017 ? 372  TYR A N   1 
ATOM   3002 C  CA  . TYR A 1 372 ? -12.99628 30.40761 -25.92804 1.000 10.22900 ? 372  TYR A CA  1 
ATOM   3003 C  C   . TYR A 1 372 ? -12.29706 29.53205 -26.96391 1.000 15.83569 ? 372  TYR A C   1 
ATOM   3004 O  O   . TYR A 1 372 ? -12.50324 28.31110 -27.01040 1.000 12.15097 ? 372  TYR A O   1 
ATOM   3005 C  CB  . TYR A 1 372 ? -14.07999 31.25093 -26.60801 1.000 10.08903 ? 372  TYR A CB  1 
ATOM   3006 C  CG  . TYR A 1 372 ? -14.88005 30.47247 -27.64426 1.000 12.02899 ? 372  TYR A CG  1 
ATOM   3007 C  CD1 . TYR A 1 372 ? -15.98653 29.70729 -27.26516 1.000 10.86740 ? 372  TYR A CD1 1 
ATOM   3008 C  CD2 . TYR A 1 372 ? -14.52944 30.49615 -28.99278 1.000 11.11044 ? 372  TYR A CD2 1 
ATOM   3009 C  CE1 . TYR A 1 372 ? -16.71672 28.98596 -28.19579 1.000 12.35619 ? 372  TYR A CE1 1 
ATOM   3010 C  CE2 . TYR A 1 372 ? -15.25524 29.77120 -29.93937 1.000 11.51321 ? 372  TYR A CE2 1 
ATOM   3011 C  CZ  . TYR A 1 372 ? -16.34881 29.01809 -29.52992 1.000 13.83648 ? 372  TYR A CZ  1 
ATOM   3012 O  OH  . TYR A 1 372 ? -17.07349 28.28769 -30.44834 1.000 14.20010 ? 372  TYR A OH  1 
ATOM   3013 N  N   . TRP A 1 373 ? -11.50756 30.14911 -27.84615 1.000 12.17034 ? 373  TRP A N   1 
ATOM   3014 C  CA  . TRP A 1 373 ? -10.78900 29.36051 -28.84053 1.000 12.68436 ? 373  TRP A CA  1 
ATOM   3015 C  C   . TRP A 1 373 ? -9.86929  28.35032 -28.17265 1.000 15.17214 ? 373  TRP A C   1 
ATOM   3016 O  O   . TRP A 1 373 ? -9.67636  27.24352 -28.69330 1.000 15.57779 ? 373  TRP A O   1 
ATOM   3017 C  CB  . TRP A 1 373 ? -10.00298 30.28295 -29.77810 1.000 13.51168 ? 373  TRP A CB  1 
ATOM   3018 C  CG  . TRP A 1 373 ? -10.90215 31.15242 -30.60568 1.000 15.72493 ? 373  TRP A CG  1 
ATOM   3019 C  CD1 . TRP A 1 373 ? -11.01980 32.51314 -30.53322 1.000 12.25591 ? 373  TRP A CD1 1 
ATOM   3020 C  CD2 . TRP A 1 373 ? -11.82135 30.72293 -31.62161 1.000 14.02032 ? 373  TRP A CD2 1 
ATOM   3021 N  NE1 . TRP A 1 373 ? -11.94485 32.95589 -31.45154 1.000 13.36843 ? 373  TRP A NE1 1 
ATOM   3022 C  CE2 . TRP A 1 373 ? -12.45669 31.87713 -32.12500 1.000 12.54650 ? 373  TRP A CE2 1 
ATOM   3023 C  CE3 . TRP A 1 373 ? -12.16428 29.47440 -32.15870 1.000 14.93375 ? 373  TRP A CE3 1 
ATOM   3024 C  CZ2 . TRP A 1 373 ? -13.41582 31.82380 -33.13348 1.000 12.99106 ? 373  TRP A CZ2 1 
ATOM   3025 C  CZ3 . TRP A 1 373 ? -13.13015 29.42245 -33.16669 1.000 17.97557 ? 373  TRP A CZ3 1 
ATOM   3026 C  CH2 . TRP A 1 373 ? -13.74646 30.59178 -33.63677 1.000 17.33550 ? 373  TRP A CH2 1 
ATOM   3027 N  N   . ALA A 1 374 ? -9.31860  28.70180 -27.00709 1.000 12.56588 ? 374  ALA A N   1 
ATOM   3028 C  CA  . ALA A 1 374 ? -8.41880  27.79584 -26.31559 1.000 14.43804 ? 374  ALA A CA  1 
ATOM   3029 C  C   . ALA A 1 374 ? -9.12891  26.54057 -25.83043 1.000 16.05122 ? 374  ALA A C   1 
ATOM   3030 O  O   . ALA A 1 374 ? -8.48429  25.50904 -25.65264 1.000 15.60741 ? 374  ALA A O   1 
ATOM   3031 C  CB  . ALA A 1 374 ? -7.74817  28.49628 -25.13786 1.000 13.88042 ? 374  ALA A CB  1 
ATOM   3032 N  N   . ILE A 1 375 ? -10.43420 26.58551 -25.59212 1.000 13.23439 ? 375  ILE A N   1 
ATOM   3033 C  CA  . ILE A 1 375 ? -11.12299 25.39908 -25.09169 1.000 11.40268 ? 375  ILE A CA  1 
ATOM   3034 C  C   . ILE A 1 375 ? -12.07162 24.80150 -26.10698 1.000 10.42477 ? 375  ILE A C   1 
ATOM   3035 O  O   . ILE A 1 375 ? -12.55954 23.67671 -25.89304 1.000 11.65877 ? 375  ILE A O   1 
ATOM   3036 C  CB  . ILE A 1 375 ? -11.85062 25.67602 -23.75578 1.000 9.86043  ? 375  ILE A CB  1 
ATOM   3037 C  CG1 . ILE A 1 375 ? -13.07561 26.57485 -23.96303 1.000 12.29140 ? 375  ILE A CG1 1 
ATOM   3038 C  CG2 . ILE A 1 375 ? -10.86633 26.25851 -22.73305 1.000 11.63892 ? 375  ILE A CG2 1 
ATOM   3039 C  CD1 . ILE A 1 375 ? -13.96435 26.66452 -22.73162 1.000 12.42340 ? 375  ILE A CD1 1 
ATOM   3040 N  N   . ILE A 1 376 ? -12.31008 25.47127 -27.23128 1.000 12.83351 ? 376  ILE A N   1 
ATOM   3041 C  CA  . ILE A 1 376 ? -13.15880 24.85646 -28.24008 1.000 10.27891 ? 376  ILE A CA  1 
ATOM   3042 C  C   . ILE A 1 376 ? -12.35975 23.93106 -29.14567 1.000 17.33564 ? 376  ILE A C   1 
ATOM   3043 O  O   . ILE A 1 376 ? -12.94595 23.04198 -29.77748 1.000 15.27281 ? 376  ILE A O   1 
ATOM   3044 C  CB  . ILE A 1 376 ? -13.90005 25.90791 -29.08231 1.000 10.09358 ? 376  ILE A CB  1 
ATOM   3045 C  CG1 . ILE A 1 376 ? -15.18523 25.31852 -29.68825 1.000 13.98456 ? 376  ILE A CG1 1 
ATOM   3046 C  CG2 . ILE A 1 376 ? -12.98157 26.48387 -30.17142 1.000 13.53359 ? 376  ILE A CG2 1 
ATOM   3047 C  CD1 . ILE A 1 376 ? -16.34938 25.08871 -28.65796 1.000 12.13544 ? 376  ILE A CD1 1 
ATOM   3048 N  N   . ASP A 1 377 ? -11.04141 24.10128 -29.21479 1.000 18.07082 ? 377  ASP A N   1 
ATOM   3049 C  CA  . ASP A 1 377 ? -10.22906 23.30842 -30.12087 1.000 19.12594 ? 377  ASP A CA  1 
ATOM   3050 C  C   . ASP A 1 377 ? -9.91479  21.94250 -29.51499 1.000 20.85441 ? 377  ASP A C   1 
ATOM   3051 O  O   . ASP A 1 377 ? -10.36949 21.59081 -28.42390 1.000 16.34005 ? 377  ASP A O   1 
ATOM   3052 C  CB  . ASP A 1 377 ? -8.94606  24.05689 -30.48681 1.000 19.50734 ? 377  ASP A CB  1 
ATOM   3053 C  CG  . ASP A 1 377 ? -7.97342  24.24939 -29.29871 1.000 20.55909 ? 377  ASP A CG  1 
ATOM   3054 O  OD1 . ASP A 1 377 ? -8.12238  23.68380 -28.17310 1.000 18.22443 ? 377  ASP A OD1 1 
ATOM   3055 O  OD2 . ASP A 1 377 ? -7.00259  25.00273 -29.52475 1.000 21.33866 ? 377  ASP A OD2 1 
ATOM   3056 N  N   . HIS A 1 378 ? -9.09835  21.16612 -30.22156 1.000 18.08770 ? 378  HIS A N   1 
ATOM   3057 C  CA  . HIS A 1 378 ? -8.71641  19.83626 -29.76583 1.000 23.38384 ? 378  HIS A CA  1 
ATOM   3058 C  C   . HIS A 1 378 ? -7.20591  19.73492 -29.62888 1.000 26.37224 ? 378  HIS A C   1 
ATOM   3059 O  O   . HIS A 1 378 ? -6.60542  18.71009 -29.94924 1.000 26.37245 ? 378  HIS A O   1 
ATOM   3060 C  CB  . HIS A 1 378 ? -9.25163  18.75338 -30.70647 1.000 22.94272 ? 378  HIS A CB  1 
ATOM   3061 C  CG  . HIS A 1 378 ? -10.73753 18.60652 -30.66342 1.000 23.15218 ? 378  HIS A CG  1 
ATOM   3062 N  ND1 . HIS A 1 378 ? -11.58513 19.41544 -31.38898 1.000 27.34808 ? 378  HIS A ND1 1 
ATOM   3063 C  CD2 . HIS A 1 378 ? -11.52976 17.76245 -29.96255 1.000 19.07670 ? 378  HIS A CD2 1 
ATOM   3064 C  CE1 . HIS A 1 378 ? -12.83696 19.06877 -31.14117 1.000 22.68067 ? 378  HIS A CE1 1 
ATOM   3065 N  NE2 . HIS A 1 378 ? -12.83114 18.06600 -30.28151 1.000 26.67524 ? 378  HIS A NE2 1 
ATOM   3066 N  N   . LYS A 1 379 ? -6.58113  20.81456 -29.17275 1.000 24.12158 ? 379  LYS A N   1 
ATOM   3067 C  CA  . LYS A 1 379 ? -5.14105  20.85221 -28.93334 1.000 25.32175 ? 379  LYS A CA  1 
ATOM   3068 C  C   . LYS A 1 379 ? -4.90454  21.30308 -27.51425 1.000 32.27859 ? 379  LYS A C   1 
ATOM   3069 O  O   . LYS A 1 379 ? -5.86096  21.61633 -26.79848 1.000 21.93367 ? 379  LYS A O   1 
ATOM   3070 C  CB  . LYS A 1 379 ? -4.42715  21.80666 -29.88802 1.000 26.88796 ? 379  LYS A CB  1 
ATOM   3071 C  CG  . LYS A 1 379 ? -4.93159  21.78128 -31.31337 1.000 41.34396 ? 379  LYS A CG  1 
ATOM   3072 C  CD  . LYS A 1 379 ? -4.09008  22.68331 -32.21030 1.000 50.69175 ? 379  LYS A CD  1 
ATOM   3073 C  CE  . LYS A 1 379 ? -4.17929  24.14668 -31.77476 1.000 59.61000 ? 379  LYS A CE  1 
ATOM   3074 N  NZ  . LYS A 1 379 ? -5.52567  24.76058 -32.04388 1.000 54.50481 ? 379  LYS A NZ  1 
ATOM   3075 O  OXT . LYS A 1 379 ? -3.76073  21.37936 -27.07098 1.000 33.86514 ? 379  LYS A OXT 1 
HETATM 3076 ZN ZN  . ZN  B 2 .   ? -14.52089 16.77487 -30.12262 1.000 78.97685 ? 401  ZN  A ZN  1 
HETATM 3077 ZN ZN  . ZN  C 2 .   ? -21.58128 33.57619 -4.61403  1.000 93.61769 ? 402  ZN  A ZN  1 
HETATM 3078 ZN ZN  . ZN  D 2 .   ? -7.18151  23.64129 -26.08704 1.000 30.12605 ? 403  ZN  A ZN  1 
HETATM 3079 ZN ZN  . ZN  E 2 .   ? -15.77811 50.78237 -21.14062 1.000 55.55411 ? 404  ZN  A ZN  1 
HETATM 3080 ZN ZN  . ZN  F 2 .   ? -17.66264 12.82394 -17.37600 1.000 48.97736 ? 405  ZN  A ZN  1 
HETATM 3081 ZN ZN  . ZN  G 2 .   ? -26.94919 22.28005 -26.50821 1.000 15.23745 ? 406  ZN  A ZN  1 
HETATM 3082 ZN ZN  . ZN  H 2 .   ? -15.47729 42.92678 -28.02017 1.000 15.63354 ? 407  ZN  A ZN  1 
HETATM 3083 CL CL  . CL  I 3 .   ? -14.66994 43.11796 -25.98657 1.000 14.85016 ? 408  CL  A CL  1 
HETATM 3084 ZN ZN  . ZN  J 2 .   ? -25.34561 38.14625 -10.66254 1.000 16.92689 ? 409  ZN  A ZN  1 
HETATM 3085 CL CL  . CL  K 3 .   ? -23.56475 38.65642 -9.52738  1.000 16.35925 ? 410  CL  A CL  1 
HETATM 3086 O  O   . HOH L 4 .   ? -34.64145 15.08889 10.40305  1.000 47.93155 ? 501  HOH A O   1 
HETATM 3087 O  O   . HOH L 4 .   ? -28.84491 36.64360 23.90169  1.000 44.33809 ? 502  HOH A O   1 
HETATM 3088 O  O   . HOH L 4 .   ? -10.22106 24.47051 -8.81909  1.000 31.25499 ? 503  HOH A O   1 
HETATM 3089 O  O   . HOH L 4 .   ? -33.41691 14.88195 16.12091  1.000 45.07721 ? 504  HOH A O   1 
HETATM 3090 O  O   . HOH L 4 .   ? -27.54921 9.88437  9.28842   1.000 35.89795 ? 505  HOH A O   1 
HETATM 3091 O  O   . HOH L 4 .   ? -10.28879 26.45847 -5.96063  1.000 29.48882 ? 506  HOH A O   1 
HETATM 3092 O  O   . HOH L 4 .   ? -33.01326 19.36918 26.36697  1.000 41.64566 ? 507  HOH A O   1 
HETATM 3093 O  O   . HOH L 4 .   ? -4.63762  11.55483 -13.21721 1.000 24.13501 ? 508  HOH A O   1 
HETATM 3094 O  O   . HOH L 4 .   ? -26.36255 13.01490 17.22486  1.000 37.51404 ? 509  HOH A O   1 
HETATM 3095 O  O   . HOH L 4 .   ? -26.89959 41.27130 -16.99702 1.000 28.57819 ? 510  HOH A O   1 
HETATM 3096 O  O   . HOH L 4 .   ? 4.71492   42.90904 -6.51503  1.000 44.45668 ? 511  HOH A O   1 
HETATM 3097 O  O   . HOH L 4 .   ? -15.226   10.411   -19.638   1.000 25.31974 ? 512  HOH A O   1 
HETATM 3098 O  O   . HOH L 4 .   ? 0.35424   27.39643 -9.79786  1.000 41.32217 ? 513  HOH A O   1 
HETATM 3099 O  O   . HOH L 4 .   ? -42.99406 13.49889 0.49024   1.000 22.44655 ? 514  HOH A O   1 
HETATM 3100 O  O   . HOH L 4 .   ? -24.30760 12.28108 14.96635  1.000 39.57525 ? 515  HOH A O   1 
HETATM 3101 O  O   . HOH L 4 .   ? -37.51475 35.26001 -15.70406 1.000 28.35222 ? 516  HOH A O   1 
HETATM 3102 O  O   . HOH L 4 .   ? -9.91980  45.09699 -21.96888 1.000 24.41087 ? 517  HOH A O   1 
HETATM 3103 O  O   . HOH L 4 .   ? -1.42060  47.77559 -16.21400 1.000 25.93466 ? 518  HOH A O   1 
HETATM 3104 O  O   . HOH L 4 .   ? -23.41127 7.00903  2.40189   1.000 32.81621 ? 519  HOH A O   1 
HETATM 3105 O  O   . HOH L 4 .   ? -5.66942  25.16917 -27.45381 1.000 18.59936 ? 520  HOH A O   1 
HETATM 3106 O  O   . HOH L 4 .   ? -7.05333  49.21214 2.27746   1.000 40.98507 ? 521  HOH A O   1 
HETATM 3107 O  O   . HOH L 4 .   ? -18.00589 7.97974  12.32536  1.000 51.82092 ? 522  HOH A O   1 
HETATM 3108 O  O   . HOH L 4 .   ? -35.50607 10.35234 -6.80279  1.000 30.97766 ? 523  HOH A O   1 
HETATM 3109 O  O   . HOH L 4 .   ? -37.40472 13.03228 8.12457   1.000 37.10178 ? 524  HOH A O   1 
HETATM 3110 O  O   . HOH L 4 .   ? -20.22533 12.02519 13.62251  1.000 39.86958 ? 525  HOH A O   1 
HETATM 3111 O  O   . HOH L 4 .   ? -12.58877 52.94841 -9.04574  1.000 24.06246 ? 526  HOH A O   1 
HETATM 3112 O  O   . HOH L 4 .   ? -28.58530 26.95445 21.76211  1.000 35.16612 ? 527  HOH A O   1 
HETATM 3113 O  O   . HOH L 4 .   ? -26.33184 14.86119 -16.38601 1.000 26.36304 ? 528  HOH A O   1 
HETATM 3114 O  O   . HOH L 4 .   ? -44.23351 29.69348 -10.23330 1.000 18.75583 ? 529  HOH A O   1 
HETATM 3115 O  O   . HOH L 4 .   ? -26.91199 39.04341 -9.84397  1.000 15.00883 ? 530  HOH A O   1 
HETATM 3116 O  O   . HOH L 4 .   ? -18.42693 32.39229 1.33622   1.000 29.45804 ? 531  HOH A O   1 
HETATM 3117 O  O   . HOH L 4 .   ? -46.207   33.596   -9.983    1.000 20.79332 ? 532  HOH A O   1 
HETATM 3118 O  O   . HOH L 4 .   ? -1.94909  43.67655 -15.46104 1.000 38.83428 ? 533  HOH A O   1 
HETATM 3119 O  O   . HOH L 4 .   ? 2.06992   52.63982 -6.37860  1.000 26.17393 ? 534  HOH A O   1 
HETATM 3120 O  O   . HOH L 4 .   ? -1.60693  42.66278 -2.36523  1.000 32.29109 ? 535  HOH A O   1 
HETATM 3121 O  O   . HOH L 4 .   ? -19.85570 12.29439 -29.89692 1.000 32.35534 ? 536  HOH A O   1 
HETATM 3122 O  O   . HOH L 4 .   ? -37.49759 31.53312 -5.72550  1.000 15.97507 ? 537  HOH A O   1 
HETATM 3123 O  O   . HOH L 4 .   ? -8.65873  44.00322 -2.52308  1.000 16.82287 ? 538  HOH A O   1 
HETATM 3124 O  O   . HOH L 4 .   ? -18.346   45.155   -29.419   1.000 15.50580 ? 539  HOH A O   1 
HETATM 3125 O  O   . HOH L 4 .   ? -1.70177  37.38148 -15.92068 1.000 27.19849 ? 540  HOH A O   1 
HETATM 3126 O  O   . HOH L 4 .   ? -34.47446 19.58570 -17.74017 1.000 22.96757 ? 541  HOH A O   1 
HETATM 3127 O  O   . HOH L 4 .   ? -32.78080 15.77937 22.37848  1.000 47.64481 ? 542  HOH A O   1 
HETATM 3128 O  O   . HOH L 4 .   ? -18.73971 25.63303 18.22448  1.000 29.85699 ? 543  HOH A O   1 
HETATM 3129 O  O   . HOH L 4 .   ? -13.87582 22.43415 -32.12119 1.000 26.95107 ? 544  HOH A O   1 
HETATM 3130 O  O   . HOH L 4 .   ? -37.30308 33.05697 -21.57363 1.000 27.11522 ? 545  HOH A O   1 
HETATM 3131 O  O   . HOH L 4 .   ? -22.34823 26.14475 8.03984   1.000 22.56273 ? 546  HOH A O   1 
HETATM 3132 O  O   . HOH L 4 .   ? -25.78614 23.39240 -28.01838 1.000 11.31064 ? 547  HOH A O   1 
HETATM 3133 O  O   . HOH L 4 .   ? -29.33385 30.29418 -5.83575  1.000 13.86671 ? 548  HOH A O   1 
HETATM 3134 O  O   . HOH L 4 .   ? -44.49000 33.66779 0.00000   0.50  24.30072 ? 549  HOH A O   1 
HETATM 3135 O  O   . HOH L 4 .   ? -24.17998 17.25447 16.22296  1.000 26.25626 ? 550  HOH A O   1 
HETATM 3136 O  O   . HOH L 4 .   ? -6.92145  15.99096 -21.97396 1.000 22.48310 ? 551  HOH A O   1 
HETATM 3137 O  O   . HOH L 4 .   ? -48.49306 36.42599 5.86747   1.000 40.80706 ? 552  HOH A O   1 
HETATM 3138 O  O   . HOH L 4 .   ? -34.93642 37.61179 -7.28875  1.000 38.98536 ? 553  HOH A O   1 
HETATM 3139 O  O   . HOH L 4 .   ? -43.68109 15.53247 -11.34470 1.000 42.29710 ? 554  HOH A O   1 
HETATM 3140 O  O   . HOH L 4 .   ? -6.92704  11.60500 5.90128   1.000 38.49957 ? 555  HOH A O   1 
HETATM 3141 O  O   . HOH L 4 .   ? -13.40802 53.05051 -21.83768 1.000 33.63267 ? 556  HOH A O   1 
HETATM 3142 O  O   . HOH L 4 .   ? -29.16046 30.46389 -29.57014 1.000 21.68207 ? 557  HOH A O   1 
HETATM 3143 O  O   . HOH L 4 .   ? -25.25838 18.60090 -15.48174 1.000 21.38051 ? 558  HOH A O   1 
HETATM 3144 O  O   . HOH L 4 .   ? -18.42616 11.26188 -12.92204 1.000 19.77888 ? 559  HOH A O   1 
HETATM 3145 O  O   . HOH L 4 .   ? -19.53054 45.53804 -13.25111 1.000 21.72186 ? 560  HOH A O   1 
HETATM 3146 O  O   . HOH L 4 .   ? -15.83735 26.87630 3.26503   1.000 12.17990 ? 561  HOH A O   1 
HETATM 3147 O  O   . HOH L 4 .   ? -38.95360 33.75380 -17.25923 1.000 23.34718 ? 562  HOH A O   1 
HETATM 3148 O  O   . HOH L 4 .   ? -11.31985 22.89679 -10.67885 1.000 20.15190 ? 563  HOH A O   1 
HETATM 3149 O  O   . HOH L 4 .   ? -6.48760  48.29849 -8.27346  1.000 14.08492 ? 564  HOH A O   1 
HETATM 3150 O  O   . HOH L 4 .   ? -41.609   11.393   8.286     1.000 41.81689 ? 565  HOH A O   1 
HETATM 3151 O  O   . HOH L 4 .   ? -26.41670 39.02350 -18.47966 1.000 14.31917 ? 566  HOH A O   1 
HETATM 3152 O  O   . HOH L 4 .   ? -23.17112 36.36352 -16.42976 1.000 12.02931 ? 567  HOH A O   1 
HETATM 3153 O  O   . HOH L 4 .   ? -32.74005 9.59170  4.58693   1.000 23.42687 ? 568  HOH A O   1 
HETATM 3154 O  O   . HOH L 4 .   ? -4.97374  50.09185 -17.99596 1.000 18.27565 ? 569  HOH A O   1 
HETATM 3155 O  O   . HOH L 4 .   ? 2.05280   20.68021 -6.03457  1.000 29.50460 ? 570  HOH A O   1 
HETATM 3156 O  O   . HOH L 4 .   ? -3.74768  43.28331 -9.95483  1.000 15.90263 ? 571  HOH A O   1 
HETATM 3157 O  O   . HOH L 4 .   ? -22.02510 27.30119 5.49540   1.000 17.07035 ? 572  HOH A O   1 
HETATM 3158 O  O   . HOH L 4 .   ? -19.82168 23.62393 9.73739   1.000 17.22157 ? 573  HOH A O   1 
HETATM 3159 O  O   . HOH L 4 .   ? -23.29556 15.82298 -22.02773 1.000 27.53212 ? 574  HOH A O   1 
HETATM 3160 O  O   . HOH L 4 .   ? 1.78043   22.64467 -7.68804  1.000 19.97627 ? 575  HOH A O   1 
HETATM 3161 O  O   . HOH L 4 .   ? -6.85688  19.00610 7.34879   1.000 34.50536 ? 576  HOH A O   1 
HETATM 3162 O  O   . HOH L 4 .   ? -19.04719 22.39006 -30.79512 1.000 13.64267 ? 577  HOH A O   1 
HETATM 3163 O  O   . HOH L 4 .   ? -2.90111  22.62476 -2.87106  1.000 26.20305 ? 578  HOH A O   1 
HETATM 3164 O  O   . HOH L 4 .   ? -18.33511 31.53144 -2.17411  1.000 36.46908 ? 579  HOH A O   1 
HETATM 3165 O  O   . HOH L 4 .   ? -42.88434 16.75313 -6.94171  1.000 26.22606 ? 580  HOH A O   1 
HETATM 3166 O  O   . HOH L 4 .   ? -24.95879 35.23259 -14.53028 1.000 13.67433 ? 581  HOH A O   1 
HETATM 3167 O  O   . HOH L 4 .   ? -35.49054 17.60330 15.92571  1.000 36.26837 ? 582  HOH A O   1 
HETATM 3168 O  O   . HOH L 4 .   ? -9.14472  22.18513 -26.13182 1.000 15.79513 ? 583  HOH A O   1 
HETATM 3169 O  O   . HOH L 4 .   ? -30.53110 33.52430 -9.33439  1.000 11.79827 ? 584  HOH A O   1 
HETATM 3170 O  O   . HOH L 4 .   ? -27.56466 24.01057 -25.62857 1.000 11.18082 ? 585  HOH A O   1 
HETATM 3171 O  O   . HOH L 4 .   ? -21.03439 45.04972 -16.94871 1.000 33.76187 ? 586  HOH A O   1 
HETATM 3172 O  O   . HOH L 4 .   ? -21.69693 9.24354  -6.89983  1.000 29.39244 ? 587  HOH A O   1 
HETATM 3173 O  O   . HOH L 4 .   ? -13.49910 26.68967 10.65885  1.000 26.86774 ? 588  HOH A O   1 
HETATM 3174 O  O   . HOH L 4 .   ? -18.53423 39.36876 -2.87247  1.000 25.77155 ? 589  HOH A O   1 
HETATM 3175 O  O   . HOH L 4 .   ? -43.85561 20.14759 5.36839   1.000 12.78611 ? 590  HOH A O   1 
HETATM 3176 O  O   . HOH L 4 .   ? -17.69361 46.87095 -9.90569  1.000 21.90852 ? 591  HOH A O   1 
HETATM 3177 O  O   . HOH L 4 .   ? -40.85281 24.30544 -19.43494 1.000 20.43610 ? 592  HOH A O   1 
HETATM 3178 O  O   . HOH L 4 .   ? -35.72134 36.75145 0.21235   1.000 24.34895 ? 593  HOH A O   1 
HETATM 3179 O  O   . HOH L 4 .   ? -7.63859  22.67881 -23.73638 1.000 14.54294 ? 594  HOH A O   1 
HETATM 3180 O  O   . HOH L 4 .   ? -38.82829 30.94253 -17.36934 1.000 20.35387 ? 595  HOH A O   1 
HETATM 3181 O  O   . HOH L 4 .   ? -4.92263  12.47985 -5.05781  1.000 23.30050 ? 596  HOH A O   1 
HETATM 3182 O  O   . HOH L 4 .   ? -5.55522  35.80667 -11.99285 1.000 16.04654 ? 597  HOH A O   1 
HETATM 3183 O  O   . HOH L 4 .   ? -24.91747 32.26825 9.49558   1.000 29.35709 ? 598  HOH A O   1 
HETATM 3184 O  O   . HOH L 4 .   ? -17.15004 50.83440 -2.29962  1.000 39.84916 ? 599  HOH A O   1 
HETATM 3185 O  O   . HOH L 4 .   ? -30.96345 32.03921 23.62585  1.000 31.46760 ? 600  HOH A O   1 
HETATM 3186 O  O   . HOH L 4 .   ? -9.64292  27.03333 -31.79363 1.000 25.76886 ? 601  HOH A O   1 
HETATM 3187 O  O   . HOH L 4 .   ? -21.60763 11.11266 -28.70716 1.000 29.03160 ? 602  HOH A O   1 
HETATM 3188 O  O   . HOH L 4 .   ? -33.25609 23.64325 31.68396  1.000 44.76492 ? 603  HOH A O   1 
HETATM 3189 O  O   . HOH L 4 .   ? -41.73599 26.00928 7.18932   1.000 13.64306 ? 604  HOH A O   1 
HETATM 3190 O  O   . HOH L 4 .   ? -23.30446 43.88767 -23.80766 1.000 25.91852 ? 605  HOH A O   1 
HETATM 3191 O  O   . HOH L 4 .   ? -45.19541 14.90819 2.92436   1.000 12.71427 ? 606  HOH A O   1 
HETATM 3192 O  O   . HOH L 4 .   ? -40.15577 26.18887 14.06756  1.000 22.26335 ? 607  HOH A O   1 
HETATM 3193 O  O   . HOH L 4 .   ? -36.43559 27.67116 22.03383  1.000 37.31741 ? 608  HOH A O   1 
HETATM 3194 O  O   . HOH L 4 .   ? 0.02286   26.91909 -21.22225 1.000 24.97512 ? 609  HOH A O   1 
HETATM 3195 O  O   . HOH L 4 .   ? -24.54267 21.15140 -34.20435 1.000 24.82194 ? 610  HOH A O   1 
HETATM 3196 O  O   . HOH L 4 .   ? -27.11661 7.94112  -5.35829  1.000 36.22925 ? 611  HOH A O   1 
HETATM 3197 O  O   . HOH L 4 .   ? -7.90402  10.29948 -19.53679 1.000 29.70467 ? 612  HOH A O   1 
HETATM 3198 O  O   . HOH L 4 .   ? -18.29187 33.71972 5.05317   1.000 38.68099 ? 613  HOH A O   1 
HETATM 3199 O  O   . HOH L 4 .   ? -25.13180 23.90017 -14.02070 1.000 11.47521 ? 614  HOH A O   1 
HETATM 3200 O  O   . HOH L 4 .   ? -30.01335 26.51954 -8.35670  1.000 10.24211 ? 615  HOH A O   1 
HETATM 3201 O  O   . HOH L 4 .   ? -11.92003 42.97495 -0.40259  1.000 26.40614 ? 616  HOH A O   1 
HETATM 3202 O  O   . HOH L 4 .   ? -8.92617  8.76866  -8.28919  1.000 27.24106 ? 617  HOH A O   1 
HETATM 3203 O  O   . HOH L 4 .   ? -33.10034 29.23034 24.34750  1.000 31.92111 ? 618  HOH A O   1 
HETATM 3204 O  O   . HOH L 4 .   ? -33.90463 41.14958 -18.79481 1.000 27.83480 ? 619  HOH A O   1 
HETATM 3205 O  O   . HOH L 4 .   ? -8.94915  10.02230 -15.10866 1.000 36.54592 ? 620  HOH A O   1 
HETATM 3206 O  O   . HOH L 4 .   ? -20.14862 10.19429 -22.51887 1.000 18.21220 ? 621  HOH A O   1 
HETATM 3207 O  O   . HOH L 4 .   ? -27.62931 40.92689 -22.29990 1.000 28.31849 ? 622  HOH A O   1 
HETATM 3208 O  O   . HOH L 4 .   ? -3.54129  20.31402 -18.44757 1.000 18.80329 ? 623  HOH A O   1 
HETATM 3209 O  O   . HOH L 4 .   ? -11.46726 57.99008 -7.66634  1.000 38.73885 ? 624  HOH A O   1 
HETATM 3210 O  O   . HOH L 4 .   ? -37.71883 32.19122 14.44978  1.000 17.95169 ? 625  HOH A O   1 
HETATM 3211 O  O   . HOH L 4 .   ? -16.41060 49.51869 -14.12983 1.000 36.70893 ? 626  HOH A O   1 
HETATM 3212 O  O   . HOH L 4 .   ? -35.07010 36.75837 5.73305   1.000 20.61135 ? 627  HOH A O   1 
HETATM 3213 O  O   . HOH L 4 .   ? -43.96974 20.14799 -7.80284  1.000 28.88914 ? 628  HOH A O   1 
HETATM 3214 O  O   . HOH L 4 .   ? -23.39792 25.00933 -9.86036  1.000 12.57772 ? 629  HOH A O   1 
HETATM 3215 O  O   . HOH L 4 .   ? -11.95501 52.10105 1.09424   1.000 42.08513 ? 630  HOH A O   1 
HETATM 3216 O  O   . HOH L 4 .   ? -43.40847 21.65746 -1.86224  1.000 13.01911 ? 631  HOH A O   1 
HETATM 3217 O  O   . HOH L 4 .   ? -11.62096 30.63457 -4.25175  1.000 17.86372 ? 632  HOH A O   1 
HETATM 3218 O  O   . HOH L 4 .   ? 2.21648   55.21597 -7.34277  1.000 43.13478 ? 633  HOH A O   1 
HETATM 3219 O  O   . HOH L 4 .   ? -23.46697 25.68058 -7.35027  1.000 15.66542 ? 634  HOH A O   1 
HETATM 3220 O  O   . HOH L 4 .   ? -31.78807 37.47565 -7.51089  1.000 27.98875 ? 635  HOH A O   1 
HETATM 3221 O  O   . HOH L 4 .   ? -9.57041  32.92288 -6.36870  1.000 27.92424 ? 636  HOH A O   1 
HETATM 3222 O  O   . HOH L 4 .   ? -27.81160 24.50637 20.94264  1.000 26.81380 ? 637  HOH A O   1 
HETATM 3223 O  O   . HOH L 4 .   ? 0.39172   39.87842 -18.06374 1.000 28.81878 ? 638  HOH A O   1 
HETATM 3224 O  O   . HOH L 4 .   ? -1.24715  15.92665 -9.74195  1.000 22.90701 ? 639  HOH A O   1 
HETATM 3225 O  O   . HOH L 4 .   ? -27.70395 35.58133 5.58509   1.000 31.65642 ? 640  HOH A O   1 
HETATM 3226 O  O   . HOH L 4 .   ? -25.73164 36.81488 3.88612   1.000 37.49682 ? 641  HOH A O   1 
HETATM 3227 O  O   . HOH L 4 .   ? -44.14399 22.61522 4.03561   1.000 12.02665 ? 642  HOH A O   1 
HETATM 3228 O  O   . HOH L 4 .   ? -1.59230  22.05059 -22.64379 1.000 37.96169 ? 643  HOH A O   1 
HETATM 3229 O  O   . HOH L 4 .   ? -19.72087 45.71979 -6.58696  1.000 33.51716 ? 644  HOH A O   1 
HETATM 3230 O  O   . HOH L 4 .   ? -11.13167 52.88388 -19.26842 1.000 34.90015 ? 645  HOH A O   1 
HETATM 3231 O  O   . HOH L 4 .   ? -28.54832 31.96830 17.26862  1.000 26.40223 ? 646  HOH A O   1 
HETATM 3232 O  O   . HOH L 4 .   ? -26.87137 9.60935  -12.62360 1.000 46.08762 ? 647  HOH A O   1 
HETATM 3233 O  O   . HOH L 4 .   ? -14.49666 25.38138 14.15519  1.000 26.65052 ? 648  HOH A O   1 
HETATM 3234 O  O   . HOH L 4 .   ? -38.18370 31.51162 17.11508  1.000 21.99066 ? 649  HOH A O   1 
HETATM 3235 O  O   . HOH L 4 .   ? -12.39124 27.14937 13.87334  1.000 27.82908 ? 650  HOH A O   1 
HETATM 3236 O  O   . HOH L 4 .   ? -18.29373 34.72090 -12.02013 1.000 14.54438 ? 651  HOH A O   1 
HETATM 3237 O  O   . HOH L 4 .   ? -30.04443 37.29040 -1.21160  1.000 35.56105 ? 652  HOH A O   1 
HETATM 3238 O  O   . HOH L 4 .   ? -33.11649 24.88164 -26.82560 1.000 29.27443 ? 653  HOH A O   1 
HETATM 3239 O  O   . HOH L 4 .   ? -8.98561  35.49075 -30.26770 1.000 25.21641 ? 654  HOH A O   1 
HETATM 3240 O  O   . HOH L 4 .   ? -14.32983 52.04722 -11.14048 1.000 29.48698 ? 655  HOH A O   1 
HETATM 3241 O  O   . HOH L 4 .   ? -12.20154 33.46754 -9.45918  1.000 12.16266 ? 656  HOH A O   1 
HETATM 3242 O  O   . HOH L 4 .   ? -15.38091 10.43244 -9.80198  1.000 24.49637 ? 657  HOH A O   1 
HETATM 3243 O  O   . HOH L 4 .   ? -7.25191  25.80127 3.68500   1.000 22.48172 ? 658  HOH A O   1 
HETATM 3244 O  O   . HOH L 4 .   ? -8.69096  27.78159 1.88262   1.000 19.56563 ? 659  HOH A O   1 
HETATM 3245 O  O   . HOH L 4 .   ? 0.04988   18.51687 -2.14413  1.000 32.65725 ? 660  HOH A O   1 
HETATM 3246 O  O   . HOH L 4 .   ? -16.51152 7.03395  -15.21760 1.000 30.91337 ? 661  HOH A O   1 
HETATM 3247 O  O   . HOH L 4 .   ? -40.97766 23.00846 10.90646  1.000 20.70060 ? 662  HOH A O   1 
HETATM 3248 O  O   . HOH L 4 .   ? -29.94335 25.26948 -23.50805 1.000 11.42047 ? 663  HOH A O   1 
HETATM 3249 O  O   . HOH L 4 .   ? -14.78843 43.83465 -2.19235  1.000 20.78253 ? 664  HOH A O   1 
HETATM 3250 O  O   . HOH L 4 .   ? -37.80506 35.66005 -1.51949  1.000 26.61285 ? 665  HOH A O   1 
HETATM 3251 O  O   . HOH L 4 .   ? -18.81630 22.35477 2.30307   1.000 14.23921 ? 666  HOH A O   1 
HETATM 3252 O  O   . HOH L 4 .   ? -9.94609  21.06004 -23.87875 1.000 13.71478 ? 667  HOH A O   1 
HETATM 3253 O  O   . HOH L 4 .   ? -7.41232  55.34903 2.55332   1.000 35.33527 ? 668  HOH A O   1 
HETATM 3254 O  O   . HOH L 4 .   ? -38.34992 25.37634 7.67254   1.000 14.61097 ? 669  HOH A O   1 
HETATM 3255 O  O   . HOH L 4 .   ? -25.91089 8.46458  -1.69046  1.000 26.18104 ? 670  HOH A O   1 
HETATM 3256 O  O   . HOH L 4 .   ? -24.90128 37.58043 -33.40997 1.000 28.44766 ? 671  HOH A O   1 
HETATM 3257 O  O   . HOH L 4 .   ? -21.75288 35.71202 -11.38421 1.000 11.81346 ? 672  HOH A O   1 
HETATM 3258 O  O   . HOH L 4 .   ? 0.71028   33.64841 -21.46130 1.000 33.32815 ? 673  HOH A O   1 
HETATM 3259 O  O   . HOH L 4 .   ? -21.74031 19.00299 -22.63097 1.000 14.03362 ? 674  HOH A O   1 
HETATM 3260 O  O   . HOH L 4 .   ? -40.35725 25.42145 9.58797   1.000 16.05630 ? 675  HOH A O   1 
HETATM 3261 O  O   . HOH L 4 .   ? -14.47187 51.47750 -0.82723  1.000 31.67168 ? 676  HOH A O   1 
HETATM 3262 O  O   . HOH L 4 .   ? -12.52175 10.41173 8.29574   1.000 26.15008 ? 677  HOH A O   1 
HETATM 3263 O  O   . HOH L 4 .   ? -15.12166 28.76697 11.55542  1.000 23.89918 ? 678  HOH A O   1 
HETATM 3264 O  O   . HOH L 4 .   ? -2.52636  37.08398 -4.95804  1.000 31.73056 ? 679  HOH A O   1 
HETATM 3265 O  O   . HOH L 4 .   ? -37.08510 21.46834 20.71281  1.000 35.40655 ? 680  HOH A O   1 
HETATM 3266 O  O   . HOH L 4 .   ? -39.84466 31.88728 12.79854  1.000 16.59731 ? 681  HOH A O   1 
HETATM 3267 O  O   . HOH L 4 .   ? -41.77260 22.01278 -10.65532 1.000 31.92420 ? 682  HOH A O   1 
HETATM 3268 O  O   . HOH L 4 .   ? -29.85876 40.42305 -19.26566 1.000 34.40778 ? 683  HOH A O   1 
HETATM 3269 O  O   . HOH L 4 .   ? -32.42610 26.86501 -0.06293  1.000 10.95347 ? 684  HOH A O   1 
HETATM 3270 O  O   . HOH L 4 .   ? -24.85362 9.02103  11.51879  1.000 41.05471 ? 685  HOH A O   1 
HETATM 3271 O  O   . HOH L 4 .   ? 0.00919   53.73222 -10.48202 1.000 36.68188 ? 686  HOH A O   1 
HETATM 3272 O  O   . HOH L 4 .   ? -32.15699 18.26355 -13.74867 1.000 11.84965 ? 687  HOH A O   1 
HETATM 3273 O  O   . HOH L 4 .   ? -12.83223 17.00618 8.88083   1.000 27.61333 ? 688  HOH A O   1 
HETATM 3274 O  O   . HOH L 4 .   ? -9.26156  37.34848 -7.61785  1.000 14.28391 ? 689  HOH A O   1 
HETATM 3275 O  O   . HOH L 4 .   ? -27.06295 20.17603 22.67915  1.000 38.65067 ? 690  HOH A O   1 
HETATM 3276 O  O   . HOH L 4 .   ? -12.55045 40.23831 -8.71922  1.000 11.79143 ? 691  HOH A O   1 
HETATM 3277 O  O   . HOH L 4 .   ? -40.37254 37.73626 3.67907   1.000 36.41248 ? 692  HOH A O   1 
HETATM 3278 O  O   . HOH L 4 .   ? -8.53569  58.95758 -10.19827 1.000 44.15315 ? 693  HOH A O   1 
HETATM 3279 O  O   . HOH L 4 .   ? -2.60834  33.60268 -9.93532  1.000 29.00612 ? 694  HOH A O   1 
HETATM 3280 O  O   . HOH L 4 .   ? -23.29673 14.62551 -16.90276 1.000 24.67211 ? 695  HOH A O   1 
HETATM 3281 O  O   . HOH L 4 .   ? -2.27687  23.34438 0.10708   1.000 26.90444 ? 696  HOH A O   1 
HETATM 3282 O  O   . HOH L 4 .   ? -7.83836  17.40398 -24.26446 1.000 30.79380 ? 697  HOH A O   1 
HETATM 3283 O  O   . HOH L 4 .   ? -1.08710  40.91401 -13.70167 1.000 35.22556 ? 698  HOH A O   1 
HETATM 3284 O  O   . HOH L 4 .   ? -40.82865 17.64038 -9.03064  1.000 18.97985 ? 699  HOH A O   1 
HETATM 3285 O  O   . HOH L 4 .   ? -30.31363 34.43226 14.06912  1.000 32.93879 ? 700  HOH A O   1 
HETATM 3286 O  O   . HOH L 4 .   ? -35.71260 7.88085  -0.61010  1.000 33.23785 ? 701  HOH A O   1 
HETATM 3287 O  O   . HOH L 4 .   ? -24.39631 23.20582 21.60018  1.000 38.64271 ? 702  HOH A O   1 
HETATM 3288 O  O   . HOH L 4 .   ? -30.15758 9.91926  -11.57985 1.000 37.60341 ? 703  HOH A O   1 
HETATM 3289 O  O   . HOH L 4 .   ? -23.97991 17.75999 -31.55487 1.000 30.30092 ? 704  HOH A O   1 
HETATM 3290 O  O   . HOH L 4 .   ? -20.65339 22.68279 17.91506  1.000 31.86090 ? 705  HOH A O   1 
HETATM 3291 O  O   . HOH L 4 .   ? -23.55015 34.39664 -6.69587  1.000 31.92413 ? 706  HOH A O   1 
HETATM 3292 O  O   . HOH L 4 .   ? -1.09375  11.02824 -15.26125 1.000 37.39719 ? 707  HOH A O   1 
HETATM 3293 O  O   . HOH L 4 .   ? -5.98908  58.46623 -3.95582  1.000 38.21008 ? 708  HOH A O   1 
HETATM 3294 O  O   . HOH L 4 .   ? -23.42048 36.00465 -0.10628  1.000 30.63585 ? 709  HOH A O   1 
HETATM 3295 O  O   . HOH L 4 .   ? -11.13746 36.96947 -29.42313 1.000 16.39075 ? 710  HOH A O   1 
HETATM 3296 O  O   . HOH L 4 .   ? -29.64342 22.36020 -23.41816 1.000 15.00596 ? 711  HOH A O   1 
HETATM 3297 O  O   . HOH L 4 .   ? -30.41282 41.41006 -25.32752 1.000 29.75928 ? 712  HOH A O   1 
HETATM 3298 O  O   . HOH L 4 .   ? -17.21450 15.35612 -26.18853 1.000 14.22315 ? 713  HOH A O   1 
HETATM 3299 O  O   . HOH L 4 .   ? -24.01221 37.68776 -18.95248 1.000 12.91146 ? 714  HOH A O   1 
HETATM 3300 O  O   . HOH L 4 .   ? -42.67531 13.86362 7.04685   1.000 38.26116 ? 715  HOH A O   1 
HETATM 3301 O  O   . HOH L 4 .   ? -21.24234 42.23037 -12.85717 1.000 16.87471 ? 716  HOH A O   1 
HETATM 3302 O  O   . HOH L 4 .   ? -27.02267 21.83727 -32.80514 1.000 30.23242 ? 717  HOH A O   1 
HETATM 3303 O  O   . HOH L 4 .   ? -10.44277 55.36359 -12.55540 1.000 33.04226 ? 718  HOH A O   1 
HETATM 3304 O  O   . HOH L 4 .   ? -31.65075 16.48686 -15.53890 1.000 22.49626 ? 719  HOH A O   1 
HETATM 3305 O  O   . HOH L 4 .   ? -11.45028 39.59118 -34.76951 1.000 17.23204 ? 720  HOH A O   1 
HETATM 3306 O  O   . HOH L 4 .   ? 4.72448   49.13547 -9.34957  1.000 41.86831 ? 721  HOH A O   1 
HETATM 3307 O  O   . HOH L 4 .   ? -19.85794 31.25175 -19.21807 1.000 9.26525  ? 722  HOH A O   1 
HETATM 3308 O  O   . HOH L 4 .   ? -23.09943 7.62250  -4.94395  1.000 33.49497 ? 723  HOH A O   1 
HETATM 3309 O  O   . HOH L 4 .   ? -25.26475 43.10144 -15.12382 1.000 33.52668 ? 724  HOH A O   1 
HETATM 3310 O  O   . HOH L 4 .   ? -40.92054 28.72970 15.28225  1.000 28.37932 ? 725  HOH A O   1 
HETATM 3311 O  O   . HOH L 4 .   ? -39.43452 18.82639 10.35722  1.000 29.78511 ? 726  HOH A O   1 
HETATM 3312 O  O   . HOH L 4 .   ? -21.30105 24.82230 20.31629  1.000 42.24685 ? 727  HOH A O   1 
HETATM 3313 O  O   . HOH L 4 .   ? -9.24673  35.12076 -22.58933 1.000 9.29353  ? 728  HOH A O   1 
HETATM 3314 O  O   . HOH L 4 .   ? -19.57251 38.75272 -35.09157 1.000 29.28321 ? 729  HOH A O   1 
HETATM 3315 O  O   . HOH L 4 .   ? -5.05899  55.47724 -13.59634 1.000 31.03770 ? 730  HOH A O   1 
HETATM 3316 O  O   . HOH L 4 .   ? -31.04892 26.60127 5.05789   1.000 21.51964 ? 731  HOH A O   1 
HETATM 3317 O  O   . HOH L 4 .   ? -1.35548  31.39490 -17.92727 1.000 19.80226 ? 732  HOH A O   1 
HETATM 3318 O  O   . HOH L 4 .   ? -12.24325 19.14694 10.33422  1.000 35.97513 ? 733  HOH A O   1 
HETATM 3319 O  O   . HOH L 4 .   ? -4.60854  41.50775 -7.91522  1.000 15.94968 ? 734  HOH A O   1 
HETATM 3320 O  O   . HOH L 4 .   ? -41.59836 13.42408 -1.80393  1.000 18.38839 ? 735  HOH A O   1 
HETATM 3321 O  O   . HOH L 4 .   ? -28.81277 6.78078  -0.41554  1.000 30.28798 ? 736  HOH A O   1 
HETATM 3322 O  O   . HOH L 4 .   ? -1.63701  25.31315 -6.09038  1.000 20.82927 ? 737  HOH A O   1 
HETATM 3323 O  O   . HOH L 4 .   ? -23.79357 11.83473 -9.57297  1.000 33.43810 ? 738  HOH A O   1 
HETATM 3324 O  O   . HOH L 4 .   ? -11.47970 34.89978 -7.24937  1.000 21.18163 ? 739  HOH A O   1 
HETATM 3325 O  O   . HOH L 4 .   ? -2.72052  32.24968 -25.02416 1.000 27.51816 ? 740  HOH A O   1 
HETATM 3326 O  O   . HOH L 4 .   ? -16.45020 37.78503 -2.00619  1.000 25.57642 ? 741  HOH A O   1 
HETATM 3327 O  O   . HOH L 4 .   ? -33.85303 41.49415 -24.94946 1.000 30.75377 ? 742  HOH A O   1 
HETATM 3328 O  O   . HOH L 4 .   ? -14.81313 32.46648 5.53831   1.000 28.45879 ? 743  HOH A O   1 
HETATM 3329 O  O   . HOH L 4 .   ? -20.90930 26.82870 -6.64549  1.000 12.12133 ? 744  HOH A O   1 
HETATM 3330 O  O   . HOH L 4 .   ? -41.85756 16.88494 -13.79064 1.000 39.13317 ? 745  HOH A O   1 
HETATM 3331 O  O   . HOH L 4 .   ? -22.90190 31.64436 -4.33501  1.000 28.80312 ? 746  HOH A O   1 
HETATM 3332 O  O   . HOH L 4 .   ? -1.73029  18.28159 -14.10323 1.000 35.70821 ? 747  HOH A O   1 
HETATM 3333 O  O   . HOH L 4 .   ? -16.37201 48.05682 -17.53735 1.000 20.84980 ? 748  HOH A O   1 
HETATM 3334 O  O   . HOH L 4 .   ? -12.86370 24.55771 -5.52441  1.000 11.92297 ? 749  HOH A O   1 
HETATM 3335 O  O   . HOH L 4 .   ? -38.61607 17.63239 -18.95673 1.000 41.82032 ? 750  HOH A O   1 
HETATM 3336 O  O   . HOH L 4 .   ? -25.42378 21.00685 20.17831  1.000 35.77726 ? 751  HOH A O   1 
HETATM 3337 O  O   . HOH L 4 .   ? -1.05929  43.90191 -23.23699 1.000 24.08738 ? 752  HOH A O   1 
HETATM 3338 O  O   . HOH L 4 .   ? -18.43620 29.34688 19.29670  1.000 34.88416 ? 753  HOH A O   1 
HETATM 3339 O  O   . HOH L 4 .   ? -3.23581  41.19964 -5.61470  1.000 28.28956 ? 754  HOH A O   1 
HETATM 3340 O  O   . HOH L 4 .   ? -28.25291 15.12788 20.14768  1.000 38.76000 ? 755  HOH A O   1 
HETATM 3341 O  O   . HOH L 4 .   ? -44.60045 33.43742 -12.52824 1.000 34.30935 ? 756  HOH A O   1 
HETATM 3342 O  O   . HOH L 4 .   ? -3.78338  43.53999 -2.50063  1.000 28.26557 ? 757  HOH A O   1 
HETATM 3343 O  O   . HOH L 4 .   ? -23.44139 28.69801 20.57073  1.000 36.94804 ? 758  HOH A O   1 
HETATM 3344 O  O   . HOH L 4 .   ? -21.94053 33.48269 15.77328  1.000 43.26490 ? 759  HOH A O   1 
HETATM 3345 O  O   . HOH L 4 .   ? -18.73186 44.64687 -2.68748  1.000 34.25216 ? 760  HOH A O   1 
HETATM 3346 O  O   . HOH L 4 .   ? -12.35889 27.81840 -5.26458  1.000 15.47033 ? 761  HOH A O   1 
HETATM 3347 O  O   . HOH L 4 .   ? -24.84780 11.79418 -12.85626 1.000 38.32630 ? 762  HOH A O   1 
HETATM 3348 O  O   . HOH L 4 .   ? 0.56161   49.19882 -10.32608 1.000 21.93906 ? 763  HOH A O   1 
HETATM 3349 O  O   . HOH L 4 .   ? -30.41815 41.26942 -28.90890 1.000 46.72356 ? 764  HOH A O   1 
HETATM 3350 O  O   . HOH L 4 .   ? -20.43991 18.04591 16.48753  1.000 28.74400 ? 765  HOH A O   1 
HETATM 3351 O  O   . HOH L 4 .   ? 2.48635   36.96407 -19.31625 1.000 31.89293 ? 766  HOH A O   1 
HETATM 3352 O  O   . HOH L 4 .   ? -42.88246 31.45530 -11.88819 1.000 23.44275 ? 767  HOH A O   1 
HETATM 3353 O  O   . HOH L 4 .   ? -26.53825 20.11913 25.25268  1.000 41.25541 ? 768  HOH A O   1 
HETATM 3354 O  O   . HOH L 4 .   ? -10.04464 16.47071 9.49036   1.000 37.14615 ? 769  HOH A O   1 
HETATM 3355 O  O   . HOH L 4 .   ? -24.81161 44.21233 -20.12401 1.000 37.15513 ? 770  HOH A O   1 
HETATM 3356 O  O   . HOH L 4 .   ? 2.73172   41.68816 -23.32437 1.000 38.90443 ? 771  HOH A O   1 
HETATM 3357 O  O   . HOH L 4 .   ? 0.74248   56.60877 -3.26337  1.000 31.99186 ? 772  HOH A O   1 
HETATM 3358 O  O   . HOH L 4 .   ? -22.42896 40.05399 -30.25765 1.000 31.77946 ? 773  HOH A O   1 
HETATM 3359 O  O   . HOH L 4 .   ? -26.32522 20.42810 -27.52169 1.000 15.99817 ? 774  HOH A O   1 
HETATM 3360 O  O   . HOH L 4 .   ? -18.43073 50.19551 -10.45105 1.000 39.74081 ? 775  HOH A O   1 
HETATM 3361 O  O   . HOH L 4 .   ? -33.05148 37.29678 7.90249   1.000 20.19791 ? 776  HOH A O   1 
HETATM 3362 O  O   . HOH L 4 .   ? -20.95585 21.34454 -32.63201 1.000 19.42841 ? 777  HOH A O   1 
HETATM 3363 O  O   . HOH L 4 .   ? -28.56324 32.29493 28.01091  1.000 47.80202 ? 778  HOH A O   1 
HETATM 3364 O  O   . HOH L 4 .   ? -36.04408 11.89802 -8.94316  1.000 36.67316 ? 779  HOH A O   1 
HETATM 3365 O  O   . HOH L 4 .   ? -17.21473 30.95585 -19.79808 1.000 10.94011 ? 780  HOH A O   1 
HETATM 3366 O  O   . HOH L 4 .   ? -25.24242 37.52830 -3.66977  1.000 35.00766 ? 781  HOH A O   1 
HETATM 3367 O  O   . HOH L 4 .   ? -24.24538 36.89392 -7.13171  1.000 22.14739 ? 782  HOH A O   1 
HETATM 3368 O  O   . HOH L 4 .   ? -40.19862 33.67187 10.81025  1.000 17.25141 ? 783  HOH A O   1 
HETATM 3369 O  O   . HOH L 4 .   ? -3.16345  33.60287 -4.70285  1.000 36.24987 ? 784  HOH A O   1 
HETATM 3370 O  O   . HOH L 4 .   ? -3.53439  46.28725 -24.26269 1.000 28.96406 ? 785  HOH A O   1 
HETATM 3371 O  O   . HOH L 4 .   ? -37.24379 28.80731 -23.80022 1.000 18.41050 ? 786  HOH A O   1 
HETATM 3372 O  O   . HOH L 4 .   ? -10.89743 21.08777 -8.14589  1.000 24.71277 ? 787  HOH A O   1 
HETATM 3373 O  O   . HOH L 4 .   ? -7.81514  21.55523 -32.92494 1.000 22.24551 ? 788  HOH A O   1 
HETATM 3374 O  O   . HOH L 4 .   ? -32.98487 14.14125 8.24794   1.000 30.05384 ? 789  HOH A O   1 
HETATM 3375 O  O   . HOH L 4 .   ? -44.85805 13.09160 -4.86968  1.000 29.37936 ? 790  HOH A O   1 
HETATM 3376 O  O   . HOH L 4 .   ? -15.22503 48.78049 -19.99375 1.000 25.49109 ? 791  HOH A O   1 
HETATM 3377 O  O   . HOH L 4 .   ? -21.48293 29.96578 -2.77858  1.000 27.97618 ? 792  HOH A O   1 
HETATM 3378 O  O   . HOH L 4 .   ? -35.98576 18.69243 -20.15481 1.000 33.41032 ? 793  HOH A O   1 
HETATM 3379 O  O   . HOH L 4 .   ? -42.43035 30.09468 -14.09749 1.000 28.50324 ? 794  HOH A O   1 
HETATM 3380 O  O   . HOH L 4 .   ? -25.44556 35.29645 7.33302   1.000 36.77658 ? 795  HOH A O   1 
HETATM 3381 O  O   . HOH L 4 .   ? -41.34393 25.48744 -13.30916 1.000 24.96306 ? 796  HOH A O   1 
HETATM 3382 O  O   . HOH L 4 .   ? -1.93758  16.34150 -16.58327 1.000 30.52246 ? 797  HOH A O   1 
HETATM 3383 O  O   . HOH L 4 .   ? -37.75558 37.13550 8.58871   1.000 30.05177 ? 798  HOH A O   1 
HETATM 3384 O  O   . HOH L 4 .   ? -21.77740 33.32509 18.76278  1.000 42.20346 ? 799  HOH A O   1 
HETATM 3385 O  O   . HOH L 4 .   ? -28.23554 21.16213 -25.19812 1.000 14.26518 ? 800  HOH A O   1 
HETATM 3386 O  O   . HOH L 4 .   ? -15.87924 32.78993 2.36394   1.000 33.66950 ? 801  HOH A O   1 
HETATM 3387 O  O   . HOH L 4 .   ? -17.57241 11.02331 -19.35951 1.000 20.00821 ? 802  HOH A O   1 
HETATM 3388 O  O   . HOH L 4 .   ? -36.37355 6.33168  -5.53144  1.000 44.12525 ? 803  HOH A O   1 
HETATM 3389 O  O   . HOH L 4 .   ? -13.62927 40.39101 -24.70579 1.000 14.71863 ? 804  HOH A O   1 
HETATM 3390 O  O   . HOH L 4 .   ? -20.71746 27.63246 -35.46730 1.000 28.03232 ? 805  HOH A O   1 
HETATM 3391 O  O   . HOH L 4 .   ? -13.19213 29.73089 7.52645   1.000 19.59330 ? 806  HOH A O   1 
HETATM 3392 O  O   . HOH L 4 .   ? -3.07984  24.75097 -27.26946 1.000 36.56846 ? 807  HOH A O   1 
HETATM 3393 O  O   . HOH L 4 .   ? -30.79873 16.71729 -19.77465 1.000 36.21689 ? 808  HOH A O   1 
HETATM 3394 O  O   . HOH L 4 .   ? -31.57364 42.04185 -19.59335 1.000 36.29172 ? 809  HOH A O   1 
HETATM 3395 O  O   . HOH L 4 .   ? -24.39066 18.36196 19.22966  1.000 39.75275 ? 810  HOH A O   1 
HETATM 3396 O  O   . HOH L 4 .   ? -41.55149 24.30426 -10.96006 1.000 27.37509 ? 811  HOH A O   1 
HETATM 3397 O  O   . HOH L 4 .   ? 0.84144   22.18751 -12.19088 1.000 23.29987 ? 812  HOH A O   1 
HETATM 3398 O  O   . HOH L 4 .   ? -18.20645 31.53610 8.99527   1.000 22.92220 ? 813  HOH A O   1 
HETATM 3399 O  O   . HOH L 4 .   ? -0.48167  27.93776 -7.53574  1.000 31.34063 ? 814  HOH A O   1 
HETATM 3400 O  O   . HOH L 4 .   ? -15.99987 53.58872 -3.37589  1.000 37.88448 ? 815  HOH A O   1 
HETATM 3401 O  O   . HOH L 4 .   ? -27.28676 25.54083 -31.43710 1.000 20.97636 ? 816  HOH A O   1 
HETATM 3402 O  O   . HOH L 4 .   ? -7.66204  19.13485 -26.31768 1.000 34.06842 ? 817  HOH A O   1 
HETATM 3403 O  O   . HOH L 4 .   ? -37.27936 32.43334 -26.32302 1.000 37.98524 ? 818  HOH A O   1 
HETATM 3404 O  O   . HOH L 4 .   ? -40.78699 10.18624 1.36231   1.000 44.78342 ? 819  HOH A O   1 
HETATM 3405 O  O   . HOH L 4 .   ? -20.13018 31.15257 -4.91885  1.000 29.79386 ? 820  HOH A O   1 
HETATM 3406 O  O   . HOH L 4 .   ? -14.71265 7.77192  -9.26548  1.000 39.40505 ? 821  HOH A O   1 
HETATM 3407 O  O   . HOH L 4 .   ? -37.98565 19.93242 -23.96989 1.000 37.36139 ? 822  HOH A O   1 
HETATM 3408 O  O   . HOH L 4 .   ? -27.48546 43.12545 -12.98706 1.000 41.91274 ? 823  HOH A O   1 
HETATM 3409 O  O   . HOH L 4 .   ? -3.45759  12.14595 -7.85328  1.000 32.45416 ? 824  HOH A O   1 
HETATM 3410 O  O   . HOH L 4 .   ? -35.24857 36.36521 9.50959   1.000 26.85047 ? 825  HOH A O   1 
HETATM 3411 O  O   . HOH L 4 .   ? -20.86434 41.88251 -8.69066  1.000 20.35002 ? 826  HOH A O   1 
HETATM 3412 O  O   . HOH L 4 .   ? -44.06643 26.78047 11.59587  1.000 32.25018 ? 827  HOH A O   1 
HETATM 3413 O  O   . HOH L 4 .   ? -9.48551  53.37686 1.48526   1.000 31.39034 ? 828  HOH A O   1 
HETATM 3414 O  O   . HOH L 4 .   ? -13.43738 15.23000 -31.53542 1.000 30.58060 ? 829  HOH A O   1 
HETATM 3415 O  O   . HOH L 4 .   ? -28.39487 28.24061 -32.03904 1.000 38.36883 ? 830  HOH A O   1 
HETATM 3416 O  O   . HOH L 4 .   ? -14.12455 20.68840 13.65889  1.000 27.97460 ? 831  HOH A O   1 
HETATM 3417 O  O   . HOH L 4 .   ? -33.93595 38.57779 -11.54549 1.000 17.75411 ? 832  HOH A O   1 
HETATM 3418 O  O   . HOH L 4 .   ? -20.41147 29.39315 -6.81513  1.000 22.59359 ? 833  HOH A O   1 
HETATM 3419 O  O   . HOH L 4 .   ? 3.931     44.563   0.076     1.000 35.09466 ? 834  HOH A O   1 
HETATM 3420 O  O   . HOH L 4 .   ? -14.27659 4.43257  -1.39114  1.000 42.38299 ? 835  HOH A O   1 
HETATM 3421 O  O   . HOH L 4 .   ? -26.21197 33.81249 10.51896  1.000 36.55002 ? 836  HOH A O   1 
HETATM 3422 O  O   . HOH L 4 .   ? -19.79071 36.67256 -36.23150 1.000 39.08121 ? 837  HOH A O   1 
HETATM 3423 O  O   . HOH L 4 .   ? -12.30265 55.70112 -1.52778  1.000 41.01405 ? 838  HOH A O   1 
HETATM 3424 O  O   . HOH L 4 .   ? -4.63483  27.52500 3.95921   1.000 29.48859 ? 839  HOH A O   1 
HETATM 3425 O  O   . HOH L 4 .   ? -4.95003  33.25536 -3.27362  1.000 31.12249 ? 840  HOH A O   1 
HETATM 3426 O  O   . HOH L 4 .   ? -22.93559 43.77119 -13.91662 1.000 27.67512 ? 841  HOH A O   1 
HETATM 3427 O  O   . HOH L 4 .   ? -6.027    39.638   -26.293   1.000 30.22044 ? 842  HOH A O   1 
HETATM 3428 O  O   . HOH L 4 .   ? -3.21466  37.07664 -12.32021 1.000 20.11289 ? 843  HOH A O   1 
HETATM 3429 O  O   . HOH L 4 .   ? -34.66560 16.73436 12.05721  1.000 39.25141 ? 844  HOH A O   1 
HETATM 3430 O  O   . HOH L 4 .   ? -11.79779 38.12040 -7.09218  1.000 18.43546 ? 845  HOH A O   1 
HETATM 3431 O  O   . HOH L 4 .   ? -21.40982 44.64672 -31.14678 1.000 19.63400 ? 846  HOH A O   1 
HETATM 3432 O  O   . HOH L 4 .   ? -21.23633 25.07447 -35.22218 1.000 31.46481 ? 847  HOH A O   1 
HETATM 3433 O  O   . HOH L 4 .   ? -18.25168 15.55306 -28.64393 1.000 29.75544 ? 848  HOH A O   1 
HETATM 3434 O  O   . HOH L 4 .   ? -1.23934  28.04903 -13.58155 1.000 34.73932 ? 849  HOH A O   1 
HETATM 3435 O  O   . HOH L 4 .   ? -17.38370 9.58640  -11.55085 1.000 36.00965 ? 850  HOH A O   1 
HETATM 3436 O  O   . HOH L 4 .   ? -42.56236 18.08497 -11.62610 1.000 33.36885 ? 851  HOH A O   1 
HETATM 3437 O  O   . HOH L 4 .   ? -35.07012 36.92055 12.22950  1.000 26.83314 ? 852  HOH A O   1 
HETATM 3438 O  O   . HOH L 4 .   ? 1.24268   35.20734 -24.89905 1.000 28.70105 ? 853  HOH A O   1 
HETATM 3439 O  O   . HOH L 4 .   ? -20.14805 12.95098 -17.67948 1.000 14.98931 ? 854  HOH A O   1 
HETATM 3440 O  O   . HOH L 4 .   ? -6.78875  16.17809 -32.02467 1.000 44.04953 ? 855  HOH A O   1 
HETATM 3441 O  O   . HOH L 4 .   ? -5.57875  28.65621 6.61282   1.000 41.85823 ? 856  HOH A O   1 
HETATM 3442 O  O   . HOH L 4 .   ? -13.51745 32.42846 -3.32120  1.000 29.50848 ? 857  HOH A O   1 
HETATM 3443 O  O   . HOH L 4 .   ? -8.65984  17.09028 -27.92272 1.000 39.08059 ? 858  HOH A O   1 
HETATM 3444 O  O   . HOH L 4 .   ? -29.28318 38.72365 -30.08825 1.000 41.09859 ? 859  HOH A O   1 
HETATM 3445 O  O   . HOH L 4 .   ? -3.541    18.619   6.041     1.000 38.03508 ? 860  HOH A O   1 
HETATM 3446 O  O   . HOH L 4 .   ? -28.49511 17.75899 -20.85846 1.000 32.03731 ? 861  HOH A O   1 
HETATM 3447 O  O   . HOH L 4 .   ? -36.00120 13.04304 11.79770  1.000 45.18017 ? 862  HOH A O   1 
HETATM 3448 O  O   . HOH L 4 .   ? -21.75802 9.01877  -27.73902 1.000 34.19471 ? 863  HOH A O   1 
HETATM 3449 O  O   . HOH L 4 .   ? -40.84064 17.97420 8.39290   1.000 33.76585 ? 864  HOH A O   1 
HETATM 3450 O  O   . HOH L 4 .   ? -28.37112 24.40841 -29.84666 1.000 31.80051 ? 865  HOH A O   1 
HETATM 3451 O  O   . HOH L 4 .   ? -25.32688 13.92651 18.97166  1.000 44.39882 ? 866  HOH A O   1 
HETATM 3452 O  O   . HOH L 4 .   ? -15.17803 33.07145 -1.59452  1.000 36.90952 ? 867  HOH A O   1 
HETATM 3453 O  O   . HOH L 4 .   ? -22.49298 41.83276 -10.73132 1.000 25.60775 ? 868  HOH A O   1 
HETATM 3454 O  O   . HOH L 4 .   ? -31.14596 23.96431 -26.19164 1.000 29.44582 ? 869  HOH A O   1 
HETATM 3455 O  O   . HOH L 4 .   ? -1.24299  21.29574 -16.87306 1.000 35.56819 ? 870  HOH A O   1 
HETATM 3456 O  O   . HOH L 4 .   ? -25.51370 29.74294 9.73042   1.000 30.29326 ? 871  HOH A O   1 
HETATM 3457 O  O   . HOH L 4 .   ? -34.36784 14.31411 -11.27244 1.000 30.46674 ? 872  HOH A O   1 
HETATM 3458 O  O   . HOH L 4 .   ? -18.66259 11.23183 -15.66409 1.000 18.17794 ? 873  HOH A O   1 
HETATM 3459 O  O   . HOH L 4 .   ? -27.30516 18.54302 -24.53862 1.000 26.60227 ? 874  HOH A O   1 
HETATM 3460 O  O   . HOH L 4 .   ? -40.93727 22.02972 -20.98740 1.000 29.21729 ? 875  HOH A O   1 
HETATM 3461 O  O   . HOH L 4 .   ? -14.83947 3.54754  -3.81919  1.000 37.53556 ? 876  HOH A O   1 
HETATM 3462 O  O   . HOH L 4 .   ? -0.24652  20.48760 -24.70342 1.000 42.18125 ? 877  HOH A O   1 
HETATM 3463 O  O   . HOH L 4 .   ? -0.39928  32.77369 -24.14848 1.000 35.78718 ? 878  HOH A O   1 
HETATM 3464 O  O   . HOH L 4 .   ? -34.55874 18.58280 23.57954  1.000 39.31284 ? 879  HOH A O   1 
HETATM 3465 O  O   . HOH L 4 .   ? -3.07040  42.07687 -12.75199 1.000 39.25801 ? 880  HOH A O   1 
HETATM 3466 O  O   . HOH L 4 .   ? -9.13952  58.91683 -6.03069  1.000 40.19818 ? 881  HOH A O   1 
HETATM 3467 O  O   . HOH L 4 .   ? -10.41019 39.35117 -28.72716 1.000 21.30676 ? 882  HOH A O   1 
HETATM 3468 O  O   . HOH L 4 .   ? -6.02340  9.92974  -5.09840  1.000 33.08654 ? 883  HOH A O   1 
HETATM 3469 O  O   . HOH L 4 .   ? 0.98634   30.80260 -19.91010 1.000 35.15138 ? 884  HOH A O   1 
HETATM 3470 O  O   . HOH L 4 .   ? -39.13664 14.11124 11.72517  1.000 46.59893 ? 885  HOH A O   1 
HETATM 3471 O  O   . HOH L 4 .   ? -8.49283  7.44941  -15.30984 1.000 49.66961 ? 886  HOH A O   1 
HETATM 3472 O  O   . HOH L 4 .   ? -17.85169 48.02978 -13.30203 1.000 40.89964 ? 887  HOH A O   1 
HETATM 3473 O  O   . HOH L 4 .   ? -31.93894 36.79507 -4.93626  1.000 30.95503 ? 888  HOH A O   1 
HETATM 3474 O  O   . HOH L 4 .   ? -35.09873 21.08114 -26.04376 1.000 38.16379 ? 889  HOH A O   1 
HETATM 3475 O  O   . HOH L 4 .   ? -1.86523  35.16418 -11.66016 1.000 33.31975 ? 890  HOH A O   1 
HETATM 3476 O  O   . HOH L 4 .   ? -21.09486 13.22659 -20.11433 1.000 27.09156 ? 891  HOH A O   1 
HETATM 3477 O  O   . HOH L 4 .   ? -7.80568  32.38510 0.37410   1.000 38.94637 ? 892  HOH A O   1 
HETATM 3478 O  O   . HOH L 4 .   ? -22.99514 14.46953 -20.20446 1.000 36.31261 ? 893  HOH A O   1 
HETATM 3479 O  O   . HOH L 4 .   ? -2.99376  25.06508 -4.04258  1.000 28.59945 ? 894  HOH A O   1 
HETATM 3480 O  O   . HOH L 4 .   ? -34.52087 15.10496 -13.35732 1.000 33.81054 ? 895  HOH A O   1 
HETATM 3481 O  O   . HOH L 4 .   ? -13.833   14.965   -27.936   1.000 34.17612 ? 896  HOH A O   1 
HETATM 3482 O  O   . HOH L 4 .   ? -6.42569  8.43319  -6.86373  1.000 39.04821 ? 897  HOH A O   1 
HETATM 3483 O  O   . HOH L 4 .   ? -34.94039 12.90933 7.10368   1.000 27.14858 ? 898  HOH A O   1 
HETATM 3484 O  O   . HOH L 4 .   ? -25.39038 43.43645 -17.35692 1.000 39.13064 ? 899  HOH A O   1 
HETATM 3485 O  O   . HOH L 4 .   ? -20.26395 20.37850 17.84461  1.000 42.54978 ? 900  HOH A O   1 
HETATM 3486 O  O   . HOH L 4 .   ? -36.60765 39.75552 -12.01297 1.000 38.51241 ? 901  HOH A O   1 
HETATM 3487 O  O   . HOH L 4 .   ? -20.09089 33.93912 2.39830   1.000 34.76657 ? 902  HOH A O   1 
HETATM 3488 O  O   . HOH L 4 .   ? -8.46930  32.39549 -2.47680  1.000 35.28702 ? 903  HOH A O   1 
HETATM 3489 O  O   . HOH L 4 .   ? -6.47702  31.34283 -1.67740  1.000 33.36099 ? 904  HOH A O   1 
HETATM 3490 O  O   . HOH L 4 .   ? -38.22458 20.35189 18.33187  1.000 36.60167 ? 905  HOH A O   1 
HETATM 3491 O  O   . HOH L 4 .   ? -41.04926 13.89684 10.40863  1.000 47.07148 ? 906  HOH A O   1 
HETATM 3492 O  O   . HOH L 4 .   ? -29.45541 27.40404 -30.28278 1.000 36.57915 ? 907  HOH A O   1 
HETATM 3493 O  O   . HOH L 4 .   ? -35.03776 27.73919 24.93945  1.000 40.21700 ? 908  HOH A O   1 
HETATM 3494 O  O   . HOH L 4 .   ? -2.61322  39.21973 -11.00392 1.000 28.45534 ? 909  HOH A O   1 
HETATM 3495 O  O   . HOH L 4 .   ? -10.61560 6.78052  -8.74179  1.000 35.73524 ? 910  HOH A O   1 
HETATM 3496 O  O   . HOH L 4 .   ? -3.84503  17.61527 -18.17083 1.000 21.05682 ? 911  HOH A O   1 
HETATM 3497 O  O   . HOH L 4 .   ? -19.930   45.716   -24.049   1.000 27.55734 ? 912  HOH A O   1 
HETATM 3498 O  O   . HOH L 4 .   ? -28.62863 22.46710 -27.76617 1.000 15.45168 ? 913  HOH A O   1 
HETATM 3499 O  O   . HOH L 4 .   ? -11.46569 30.01903 9.13031   1.000 36.35848 ? 914  HOH A O   1 
HETATM 3500 O  O   . HOH L 4 .   ? -27.95163 30.54507 -31.86416 1.000 37.22632 ? 915  HOH A O   1 
HETATM 3501 O  O   . HOH L 4 .   ? -37.14421 31.48546 -24.19776 1.000 27.26431 ? 916  HOH A O   1 
HETATM 3502 O  O   . HOH L 4 .   ? 2.82276   22.40209 -9.85808  1.000 30.63269 ? 917  HOH A O   1 
HETATM 3503 O  O   . HOH L 4 .   ? -10.75878 15.96568 -27.97503 1.000 26.29341 ? 918  HOH A O   1 
HETATM 3504 O  O   . HOH L 4 .   ? -8.74149  30.77402 8.17273   1.000 39.26325 ? 919  HOH A O   1 
HETATM 3505 O  O   . HOH L 4 .   ? -20.87240 44.51004 -8.62933  1.000 26.40077 ? 920  HOH A O   1 
HETATM 3506 O  O   . HOH L 4 .   ? 6.32380   48.18374 -4.93312  1.000 41.21470 ? 921  HOH A O   1 
HETATM 3507 O  O   . HOH L 4 .   ? -28.86799 20.86686 -31.18075 1.000 44.42058 ? 922  HOH A O   1 
HETATM 3508 O  O   . HOH L 4 .   ? -27.25561 16.13927 -20.48027 1.000 41.84299 ? 923  HOH A O   1 
HETATM 3509 O  O   . HOH L 4 .   ? -22.20375 35.56372 -2.83139  1.000 35.15852 ? 924  HOH A O   1 
HETATM 3510 O  O   . HOH L 4 .   ? -22.38386 40.73207 -6.37172  1.000 36.26569 ? 925  HOH A O   1 
HETATM 3511 O  O   . HOH L 4 .   ? -11.30986 15.70499 -32.85524 1.000 39.31212 ? 926  HOH A O   1 
HETATM 3512 O  O   . HOH L 4 .   ? -28.00228 19.36871 -29.33015 1.000 32.17240 ? 927  HOH A O   1 
HETATM 3513 O  O   . HOH L 4 .   ? -10.51977 31.70623 -38.55480 1.000 54.32508 ? 928  HOH A O   1 
HETATM 3514 O  O   . HOH L 4 .   ? -37.44765 8.40237  -6.85911  1.000 41.92568 ? 929  HOH A O   1 
HETATM 3515 O  O   . HOH L 4 .   ? -24.59102 18.46454 -26.35050 1.000 19.44915 ? 930  HOH A O   1 
HETATM 3516 O  O   . HOH L 4 .   ? -11.10329 25.84024 -33.49242 1.000 23.28648 ? 931  HOH A O   1 
HETATM 3517 O  O   . HOH L 4 .   ? -34.17093 7.87786  3.15183   1.000 30.31882 ? 932  HOH A O   1 
HETATM 3518 O  O   . HOH L 4 .   ? -3.38208  31.34785 -1.83524  1.000 36.67465 ? 933  HOH A O   1 
HETATM 3519 O  O   . HOH L 4 .   ? -11.44679 39.24761 -26.15830 1.000 22.34791 ? 934  HOH A O   1 
HETATM 3520 O  O   . HOH L 4 .   ? -21.15010 10.29465 -13.06095 1.000 36.17162 ? 935  HOH A O   1 
HETATM 3521 O  O   . HOH L 4 .   ? -18.330   8.707    -16.494   1.000 27.29838 ? 936  HOH A O   1 
HETATM 3522 O  O   . HOH L 4 .   ? -33.99726 9.68754  6.83806   1.000 30.85960 ? 937  HOH A O   1 
HETATM 3523 O  O   . HOH L 4 .   ? -43.90404 22.96359 -9.93003  1.000 34.67316 ? 938  HOH A O   1 
HETATM 3524 O  O   . HOH L 4 .   ? -40.07953 23.42809 13.41382  1.000 32.10094 ? 939  HOH A O   1 
HETATM 3525 O  O   . HOH L 4 .   ? 1.73717   44.30149 -11.60553 1.000 42.66143 ? 940  HOH A O   1 
HETATM 3526 O  O   . HOH L 4 .   ? 0.72574   40.16218 -14.91150 1.000 37.69718 ? 941  HOH A O   1 
HETATM 3527 O  O   . HOH L 4 .   ? -35.18586 36.24242 -4.73773  1.000 34.85272 ? 942  HOH A O   1 
HETATM 3528 O  O   . HOH L 4 .   ? -38.02365 17.80856 17.41183  1.000 42.93897 ? 943  HOH A O   1 
HETATM 3529 O  O   . HOH L 4 .   ? -30.32687 36.40580 -30.56896 1.000 38.52120 ? 944  HOH A O   1 
HETATM 3530 O  O   . HOH L 4 .   ? -3.18944  52.49832 -14.81434 1.000 46.54029 ? 945  HOH A O   1 
HETATM 3531 O  O   . HOH L 4 .   ? -0.84087  42.45744 -18.50221 1.000 28.24782 ? 946  HOH A O   1 
HETATM 3532 O  O   . HOH L 4 .   ? -5.82778  34.62355 2.09386   1.000 45.54853 ? 947  HOH A O   1 
HETATM 3533 O  O   . HOH L 4 .   ? -13.496   20.726   -34.645   1.000 31.99547 ? 948  HOH A O   1 
HETATM 3534 O  O   . HOH L 4 .   ? -10.27123 33.15774 -1.52600  1.000 34.89913 ? 949  HOH A O   1 
HETATM 3535 O  O   . HOH L 4 .   ? 0.54093   18.78871 -13.99595 1.000 41.30959 ? 950  HOH A O   1 
HETATM 3536 O  O   . HOH L 4 .   ? -32.47317 9.78742  8.85988   1.000 32.18361 ? 951  HOH A O   1 
HETATM 3537 O  O   . HOH L 4 .   ? -7.31582  30.11610 2.70642   1.000 29.27498 ? 952  HOH A O   1 
HETATM 3538 O  O   . HOH L 4 .   ? -17.05279 35.76845 -0.12313  1.000 35.95965 ? 953  HOH A O   1 
HETATM 3539 O  O   . HOH L 4 .   ? -36.28545 16.52663 13.61675  1.000 44.35007 ? 954  HOH A O   1 
HETATM 3540 O  O   . HOH L 4 .   ? -1.80906  13.70784 -8.68111  1.000 40.87838 ? 955  HOH A O   1 
HETATM 3541 O  O   . HOH L 4 .   ? -27.89633 42.57783 -19.74589 1.000 37.31818 ? 956  HOH A O   1 
HETATM 3542 O  O   . HOH L 4 .   ? -16.71792 29.76746 -36.52289 1.000 35.35388 ? 957  HOH A O   1 
HETATM 3543 O  O   . HOH L 4 .   ? -12.61018 19.21172 12.95625  1.000 35.71956 ? 958  HOH A O   1 
HETATM 3544 O  O   . HOH L 4 .   ? -8.879    14.545   -24.770   1.000 30.76639 ? 959  HOH A O   1 
HETATM 3545 O  O   . HOH L 4 .   ? -43.42886 27.40611 -13.84143 1.000 33.80693 ? 960  HOH A O   1 
HETATM 3546 O  O   . HOH L 4 .   ? -33.61971 16.88768 -17.41727 1.000 35.79181 ? 961  HOH A O   1 
HETATM 3547 O  O   . HOH L 4 .   ? -2.46359  10.06916 -12.32175 1.000 42.11477 ? 962  HOH A O   1 
HETATM 3548 O  O   . HOH L 4 .   ? 1.61214   48.43460 -12.26611 1.000 37.59948 ? 963  HOH A O   1 
HETATM 3549 O  O   . HOH L 4 .   ? -38.95495 28.66376 -21.29173 1.000 25.18316 ? 964  HOH A O   1 
HETATM 3550 O  O   . HOH L 4 .   ? -0.14031  42.89214 -12.36718 1.000 40.57537 ? 965  HOH A O   1 
HETATM 3551 O  O   . HOH L 4 .   ? -26.496   17.601   -31.435   1.000 36.20148 ? 966  HOH A O   1 
HETATM 3552 O  O   . HOH L 4 .   ? -0.28428  32.97678 -8.63774  1.000 34.91775 ? 967  HOH A O   1 
HETATM 3553 O  O   . HOH L 4 .   ? -13.27633 41.26478 -1.69417  1.000 30.91161 ? 968  HOH A O   1 
HETATM 3554 O  O   . HOH L 4 .   ? -33.06142 16.34885 -19.81140 1.000 41.42343 ? 969  HOH A O   1 
HETATM 3555 O  O   . HOH L 4 .   ? -41.67947 23.50862 -14.86418 1.000 32.24229 ? 970  HOH A O   1 
HETATM 3556 O  O   . HOH L 4 .   ? -28.24692 41.22678 -10.72427 1.000 39.34444 ? 971  HOH A O   1 
HETATM 3557 O  O   . HOH L 4 .   ? -19.13874 33.70806 -1.12518  1.000 37.37094 ? 972  HOH A O   1 
HETATM 3558 O  O   . HOH L 4 .   ? -38.69673 27.76862 -25.71412 1.000 37.66438 ? 973  HOH A O   1 
HETATM 3559 O  O   . HOH L 4 .   ? -16.03592 31.07262 10.89341  1.000 39.10831 ? 974  HOH A O   1 
HETATM 3560 O  O   . HOH L 4 .   ? -38.54296 36.59735 17.05789  1.000 39.63151 ? 975  HOH A O   1 
HETATM 3561 O  O   . HOH L 4 .   ? -12.65961 6.92890  -10.95119 1.000 46.08190 ? 976  HOH A O   1 
HETATM 3562 O  O   . HOH L 4 .   ? -11.97579 31.30496 12.92283  1.000 49.09105 ? 977  HOH A O   1 
HETATM 3563 O  O   . HOH L 4 .   ? -20.44784 46.26048 -10.99030 1.000 31.92618 ? 978  HOH A O   1 
HETATM 3564 O  O   . HOH L 4 .   ? -0.11648  35.63993 -14.82462 1.000 37.96818 ? 979  HOH A O   1 
HETATM 3565 O  O   . HOH L 4 .   ? -15.13604 54.48954 -1.36250  1.000 38.94318 ? 980  HOH A O   1 
HETATM 3566 O  O   . HOH L 4 .   ? -13.64553 29.67762 13.78030  1.000 34.55091 ? 981  HOH A O   1 
HETATM 3567 O  O   . HOH L 4 .   ? 3.89634   55.19605 -9.74115  1.000 36.36047 ? 982  HOH A O   1 
HETATM 3568 O  O   . HOH L 4 .   ? -24.59491 42.90428 -10.45412 1.000 34.21546 ? 983  HOH A O   1 
HETATM 3569 O  O   . HOH L 4 .   ? -10.90478 33.22955 0.53002   1.000 34.74714 ? 984  HOH A O   1 
HETATM 3570 O  O   . HOH L 4 .   ? -8.40909  50.92386 2.96889   1.000 36.64353 ? 985  HOH A O   1 
HETATM 3571 O  O   . HOH L 4 .   ? -45.21851 17.30885 -8.69630  1.000 40.99398 ? 986  HOH A O   1 
HETATM 3572 O  O   . HOH L 4 .   ? -42.32913 25.82861 -20.90546 1.000 32.05464 ? 987  HOH A O   1 
HETATM 3573 O  O   . HOH L 4 .   ? 0.00000   57.93418 0.00000   0.50  26.25538 ? 988  HOH A O   1 
HETATM 3574 O  O   . HOH L 4 .   ? -14.85090 39.26426 -0.45918  1.000 31.91956 ? 989  HOH A O   1 
HETATM 3575 O  O   . HOH L 4 .   ? 2.85131   40.04505 -18.76860 1.000 40.02682 ? 990  HOH A O   1 
HETATM 3576 O  O   . HOH L 4 .   ? -2.14583  49.60669 -17.95296 1.000 32.23799 ? 991  HOH A O   1 
HETATM 3577 O  O   . HOH L 4 .   ? -22.564   41.935   -31.902   1.000 25.66983 ? 992  HOH A O   1 
HETATM 3578 O  O   . HOH L 4 .   ? -15.63014 4.92380  -14.74626 1.000 33.41974 ? 993  HOH A O   1 
HETATM 3579 O  O   . HOH L 4 .   ? -20.50969 43.23369 -2.00028  1.000 41.93096 ? 994  HOH A O   1 
HETATM 3580 O  O   . HOH L 4 .   ? -20.84825 32.20714 10.12845  1.000 23.07746 ? 995  HOH A O   1 
HETATM 3581 O  O   . HOH L 4 .   ? -0.71796  32.62796 -5.66989  1.000 36.33106 ? 996  HOH A O   1 
HETATM 3582 O  O   . HOH L 4 .   ? -36.70486 18.99580 22.13162  1.000 43.05205 ? 997  HOH A O   1 
HETATM 3583 O  O   . HOH L 4 .   ? -3.157    56.108   4.740     1.000 39.67324 ? 998  HOH A O   1 
HETATM 3584 O  O   . HOH L 4 .   ? -18.81631 41.09918 -0.74663  1.000 42.16607 ? 999  HOH A O   1 
HETATM 3585 O  O   . HOH L 4 .   ? -1.76477  20.91808 -20.59061 1.000 33.67878 ? 1000 HOH A O   1 
HETATM 3586 O  O   . HOH L 4 .   ? -26.98155 33.58667 15.28880  1.000 30.72569 ? 1001 HOH A O   1 
HETATM 3587 O  O   . HOH L 4 .   ? -13.53112 43.86237 1.78277   1.000 39.65791 ? 1002 HOH A O   1 
HETATM 3588 O  O   . HOH L 4 .   ? -31.63310 12.62155 9.90441   1.000 35.76459 ? 1003 HOH A O   1 
HETATM 3589 O  O   . HOH L 4 .   ? -42.91915 11.25054 2.16489   1.000 38.36065 ? 1004 HOH A O   1 
HETATM 3590 O  O   . HOH L 4 .   ? 0.52122   43.90519 -20.61930 1.000 36.01926 ? 1005 HOH A O   1 
HETATM 3591 O  O   . HOH L 4 .   ? -3.54000  12.40199 -2.60075  1.000 36.11951 ? 1006 HOH A O   1 
HETATM 3592 O  O   . HOH L 4 .   ? -33.33122 15.38563 13.29641  1.000 39.69624 ? 1007 HOH A O   1 
HETATM 3593 O  O   . HOH L 4 .   ? -41.07743 27.72825 -21.92509 1.000 31.58526 ? 1008 HOH A O   1 
HETATM 3594 O  O   . HOH L 4 .   ? -42.47582 23.54788 -17.17137 1.000 28.77797 ? 1009 HOH A O   1 
HETATM 3595 O  O   . HOH L 4 .   ? -15.59980 44.18667 0.16551   1.000 32.10190 ? 1010 HOH A O   1 
HETATM 3596 O  O   . HOH L 4 .   ? -37.65014 36.57404 13.03693  1.000 28.87624 ? 1011 HOH A O   1 
HETATM 3597 O  O   . HOH L 4 .   ? -38.67879 31.09540 -20.12603 1.000 30.67332 ? 1012 HOH A O   1 
HETATM 3598 O  O   . HOH L 4 .   ? -36.58337 7.15520  3.80195   1.000 38.19585 ? 1013 HOH A O   1 
HETATM 3599 O  O   . HOH L 4 .   ? -5.74956  51.38139 -15.44730 1.000 24.49793 ? 1014 HOH A O   1 
HETATM 3600 O  O   . HOH L 4 .   ? -39.09708 36.17731 10.54939  1.000 25.52488 ? 1015 HOH A O   1 
HETATM 3601 O  O   . HOH L 4 .   ? 0.52926   33.13003 -16.56869 1.000 38.46475 ? 1016 HOH A O   1 
HETATM 3602 O  O   . HOH L 4 .   ? -22.96764 38.45118 -4.58503  1.000 43.54329 ? 1017 HOH A O   1 
HETATM 3603 O  O   . HOH L 4 .   ? -35.06828 38.63055 3.72418   1.000 30.06549 ? 1018 HOH A O   1 
HETATM 3604 O  O   . HOH L 4 .   ? 0.48391   22.02375 -18.85520 1.000 36.80924 ? 1019 HOH A O   1 
HETATM 3605 O  O   . HOH L 4 .   ? -17.88938 45.72067 -18.97229 1.000 32.10323 ? 1020 HOH A O   1 
HETATM 3606 O  O   . HOH L 4 .   ? 2.96295   42.71028 -20.92330 1.000 44.34254 ? 1021 HOH A O   1 
HETATM 3607 O  O   . HOH L 4 .   ? -11.11099 41.34792 1.20314   1.000 41.22571 ? 1022 HOH A O   1 
HETATM 3608 O  O   . HOH L 4 .   ? 0.36656   30.43122 -5.77539  1.000 36.92581 ? 1023 HOH A O   1 
HETATM 3609 O  O   . HOH L 4 .   ? -1.67258  18.20476 -21.94958 1.000 37.19224 ? 1024 HOH A O   1 
HETATM 3610 O  O   . HOH L 4 .   ? -5.99479  59.97476 -1.54088  1.000 42.45990 ? 1025 HOH A O   1 
HETATM 3611 O  O   . HOH L 4 .   ? -38.67929 34.78469 14.53238  1.000 33.51661 ? 1026 HOH A O   1 
HETATM 3612 O  O   . HOH L 4 .   ? -35.95171 13.72850 14.41076  1.000 46.78464 ? 1027 HOH A O   1 
HETATM 3613 O  O   . HOH L 4 .   ? -1.81727  48.82888 -20.46801 1.000 38.15858 ? 1028 HOH A O   1 
HETATM 3614 O  O   . HOH L 4 .   ? -8.07301  55.33531 -14.31478 1.000 37.85922 ? 1029 HOH A O   1 
HETATM 3615 O  O   . HOH L 4 .   ? -1.917    59.972   0.394     1.000 30.85129 ? 1030 HOH A O   1 
HETATM 3616 O  O   . HOH L 4 .   ? -33.88141 38.43452 13.72405  1.000 33.31573 ? 1031 HOH A O   1 
HETATM 3617 O  O   . HOH L 4 .   ? -3.968    18.274   8.161     1.000 41.79639 ? 1032 HOH A O   1 
HETATM 3618 O  O   . HOH L 4 .   ? -7.76695  53.45981 -16.26204 1.000 39.51747 ? 1033 HOH A O   1 
HETATM 3619 O  O   . HOH L 4 .   ? -15.12001 27.99004 -36.37549 1.000 40.56146 ? 1034 HOH A O   1 
HETATM 3620 O  O   . HOH L 4 .   ? -1.15116  32.07316 -1.21312  1.000 35.24762 ? 1035 HOH A O   1 
HETATM 3621 O  O   . HOH L 4 .   ? 2.88432   30.19338 -6.49785  1.000 39.72496 ? 1036 HOH A O   1 
HETATM 3622 O  O   . HOH L 4 .   ? 1.13364   30.15474 -23.91587 1.000 40.13215 ? 1037 HOH A O   1 
HETATM 3623 O  O   . HOH L 4 .   ? -1.03728  52.49989 -17.17993 1.000 46.66197 ? 1038 HOH A O   1 
HETATM 3624 O  O   . HOH L 4 .   ? -38.46438 38.82223 14.52041  1.000 41.42264 ? 1039 HOH A O   1 
# 
