data_9FER
# 
_entry.id   9FER 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FER         pdb_00009fer 10.2210/pdb9fer/pdb 
WWPDB D_1292134422 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-04 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FER 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              brynda@uochb.cas.cz 
_pdbx_contact_author.name_first         Jiri 
_pdbx_contact_author.name_last          Brynda 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3675-6769 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Myskova, J.' 1 ? 
'Brynda, J.'  2 ? 
'Lazar, J.'   3 ? 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? ? ? ? primary 'To Be Published' ? 0353 ? ? ? ? ? ? ? 'Directionality of Optical Properties of Fluorescent Proteins' 
? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? 1       'To Be Published' ? 0353 ? ? ? ? ? ? ? 'Directional optical properties of fluorescent proteins'       
? ? ? ? ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Myskova, J.'   1 ? 
primary 'Brynda, J.'    2 ? 
primary 'Khoroshyy, P.' 3 ? 
primary 'Lazar, J.'     4 ? 
1       'Myskova, J.'   5 ? 
1       'Lazar, J.'     6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Fluorescent protein plum' 29499.219 2   ? ? ? ? 
2 water   nat water                      18.015    329 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;HHHHHHGMASMTGGQQMGRDLYENLYFQGSSMVSKGEEVIKEFMRFKEHMEGSVNGHEFEIEGEGEGRPYEGTQTARLKV
TKGGPLPFAWDILSPQIMYG(CH6)SKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVK
VRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEMKMRLRLKDGGHYDAEVKTTYMAKKPVQLPGAYKTDIKLDITS
HNEDYTIVEQYERAEGRHSTGA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;HHHHHHGMASMTGGQQMGRDLYENLYFQGSSMVSKGEEVIKEFMRFKEHMEGSVNGHEFEIEGEGEGRPYEGTQTARLKV
TKGGPLPFAWDILSPQIMYGMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKVR
GTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEMKMRLRLKDGGHYDAEVKTTYMAKKPVQLPGAYKTDIKLDITSHN
EDYTIVEQYERAEGRHSTGA
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   GLY n 
1 8   MET n 
1 9   ALA n 
1 10  SER n 
1 11  MET n 
1 12  THR n 
1 13  GLY n 
1 14  GLY n 
1 15  GLN n 
1 16  GLN n 
1 17  MET n 
1 18  GLY n 
1 19  ARG n 
1 20  ASP n 
1 21  LEU n 
1 22  TYR n 
1 23  GLU n 
1 24  ASN n 
1 25  LEU n 
1 26  TYR n 
1 27  PHE n 
1 28  GLN n 
1 29  GLY n 
1 30  SER n 
1 31  SER n 
1 32  MET n 
1 33  VAL n 
1 34  SER n 
1 35  LYS n 
1 36  GLY n 
1 37  GLU n 
1 38  GLU n 
1 39  VAL n 
1 40  ILE n 
1 41  LYS n 
1 42  GLU n 
1 43  PHE n 
1 44  MET n 
1 45  ARG n 
1 46  PHE n 
1 47  LYS n 
1 48  GLU n 
1 49  HIS n 
1 50  MET n 
1 51  GLU n 
1 52  GLY n 
1 53  SER n 
1 54  VAL n 
1 55  ASN n 
1 56  GLY n 
1 57  HIS n 
1 58  GLU n 
1 59  PHE n 
1 60  GLU n 
1 61  ILE n 
1 62  GLU n 
1 63  GLY n 
1 64  GLU n 
1 65  GLY n 
1 66  GLU n 
1 67  GLY n 
1 68  ARG n 
1 69  PRO n 
1 70  TYR n 
1 71  GLU n 
1 72  GLY n 
1 73  THR n 
1 74  GLN n 
1 75  THR n 
1 76  ALA n 
1 77  ARG n 
1 78  LEU n 
1 79  LYS n 
1 80  VAL n 
1 81  THR n 
1 82  LYS n 
1 83  GLY n 
1 84  GLY n 
1 85  PRO n 
1 86  LEU n 
1 87  PRO n 
1 88  PHE n 
1 89  ALA n 
1 90  TRP n 
1 91  ASP n 
1 92  ILE n 
1 93  LEU n 
1 94  SER n 
1 95  PRO n 
1 96  GLN n 
1 97  ILE n 
1 98  MET n 
1 99  TYR n 
1 100 GLY n 
1 101 CH6 n 
1 102 SER n 
1 103 LYS n 
1 104 ALA n 
1 105 TYR n 
1 106 VAL n 
1 107 LYS n 
1 108 HIS n 
1 109 PRO n 
1 110 ALA n 
1 111 ASP n 
1 112 ILE n 
1 113 PRO n 
1 114 ASP n 
1 115 TYR n 
1 116 LEU n 
1 117 LYS n 
1 118 LEU n 
1 119 SER n 
1 120 PHE n 
1 121 PRO n 
1 122 GLU n 
1 123 GLY n 
1 124 PHE n 
1 125 LYS n 
1 126 TRP n 
1 127 GLU n 
1 128 ARG n 
1 129 VAL n 
1 130 MET n 
1 131 ASN n 
1 132 PHE n 
1 133 GLU n 
1 134 ASP n 
1 135 GLY n 
1 136 GLY n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 VAL n 
1 141 THR n 
1 142 GLN n 
1 143 ASP n 
1 144 SER n 
1 145 SER n 
1 146 LEU n 
1 147 GLN n 
1 148 ASP n 
1 149 GLY n 
1 150 GLU n 
1 151 PHE n 
1 152 ILE n 
1 153 TYR n 
1 154 LYS n 
1 155 VAL n 
1 156 LYS n 
1 157 VAL n 
1 158 ARG n 
1 159 GLY n 
1 160 THR n 
1 161 ASN n 
1 162 PHE n 
1 163 PRO n 
1 164 SER n 
1 165 ASP n 
1 166 GLY n 
1 167 PRO n 
1 168 VAL n 
1 169 MET n 
1 170 GLN n 
1 171 LYS n 
1 172 LYS n 
1 173 THR n 
1 174 MET n 
1 175 GLY n 
1 176 TRP n 
1 177 GLU n 
1 178 ALA n 
1 179 SER n 
1 180 SER n 
1 181 GLU n 
1 182 ARG n 
1 183 MET n 
1 184 TYR n 
1 185 PRO n 
1 186 GLU n 
1 187 ASP n 
1 188 GLY n 
1 189 ALA n 
1 190 LEU n 
1 191 LYS n 
1 192 GLY n 
1 193 GLU n 
1 194 MET n 
1 195 LYS n 
1 196 MET n 
1 197 ARG n 
1 198 LEU n 
1 199 ARG n 
1 200 LEU n 
1 201 LYS n 
1 202 ASP n 
1 203 GLY n 
1 204 GLY n 
1 205 HIS n 
1 206 TYR n 
1 207 ASP n 
1 208 ALA n 
1 209 GLU n 
1 210 VAL n 
1 211 LYS n 
1 212 THR n 
1 213 THR n 
1 214 TYR n 
1 215 MET n 
1 216 ALA n 
1 217 LYS n 
1 218 LYS n 
1 219 PRO n 
1 220 VAL n 
1 221 GLN n 
1 222 LEU n 
1 223 PRO n 
1 224 GLY n 
1 225 ALA n 
1 226 TYR n 
1 227 LYS n 
1 228 THR n 
1 229 ASP n 
1 230 ILE n 
1 231 LYS n 
1 232 LEU n 
1 233 ASP n 
1 234 ILE n 
1 235 THR n 
1 236 SER n 
1 237 HIS n 
1 238 ASN n 
1 239 GLU n 
1 240 ASP n 
1 241 TYR n 
1 242 THR n 
1 243 ILE n 
1 244 VAL n 
1 245 GLU n 
1 246 GLN n 
1 247 TYR n 
1 248 GLU n 
1 249 ARG n 
1 250 ALA n 
1 251 GLU n 
1 252 GLY n 
1 253 ARG n 
1 254 HIS n 
1 255 SER n 
1 256 THR n 
1 257 GLY n 
1 258 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   258 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Discosoma sp. LW-2004' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     301246 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                           'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE ?                           'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                           'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                           'C4 H7 N O4'      133.103 
CH6 'L-peptide linking' n 
'{(4Z)-2-[(1S)-1-amino-3-(methylsulfanyl)propyl]-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid' 
'CHROMOPHORE (MET-TYR-GLY)' 'C16 H19 N3 O4 S' 349.405 
GLN 'L-peptide linking' y GLUTAMINE ?                           'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                           'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE ?                           'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE ?                           'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER ?                           'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                           'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE ?                           'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE ?                           'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE ?                           'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                           'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE ?                           'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE ?                           'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE ?                           'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                           'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE ?                           'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE ?                           'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   -31 ?   ?   ?   A . n 
A 1 2   HIS 2   -30 ?   ?   ?   A . n 
A 1 3   HIS 3   -29 ?   ?   ?   A . n 
A 1 4   HIS 4   -28 ?   ?   ?   A . n 
A 1 5   HIS 5   -27 ?   ?   ?   A . n 
A 1 6   HIS 6   -26 ?   ?   ?   A . n 
A 1 7   GLY 7   -25 ?   ?   ?   A . n 
A 1 8   MET 8   -24 ?   ?   ?   A . n 
A 1 9   ALA 9   -23 ?   ?   ?   A . n 
A 1 10  SER 10  -22 ?   ?   ?   A . n 
A 1 11  MET 11  -21 ?   ?   ?   A . n 
A 1 12  THR 12  -20 ?   ?   ?   A . n 
A 1 13  GLY 13  -19 ?   ?   ?   A . n 
A 1 14  GLY 14  -18 ?   ?   ?   A . n 
A 1 15  GLN 15  -17 ?   ?   ?   A . n 
A 1 16  GLN 16  -16 ?   ?   ?   A . n 
A 1 17  MET 17  -15 ?   ?   ?   A . n 
A 1 18  GLY 18  -14 ?   ?   ?   A . n 
A 1 19  ARG 19  -13 ?   ?   ?   A . n 
A 1 20  ASP 20  -12 ?   ?   ?   A . n 
A 1 21  LEU 21  -11 ?   ?   ?   A . n 
A 1 22  TYR 22  -10 ?   ?   ?   A . n 
A 1 23  GLU 23  -9  ?   ?   ?   A . n 
A 1 24  ASN 24  -8  ?   ?   ?   A . n 
A 1 25  LEU 25  -7  ?   ?   ?   A . n 
A 1 26  TYR 26  -6  ?   ?   ?   A . n 
A 1 27  PHE 27  -5  ?   ?   ?   A . n 
A 1 28  GLN 28  -4  ?   ?   ?   A . n 
A 1 29  GLY 29  -3  ?   ?   ?   A . n 
A 1 30  SER 30  -2  ?   ?   ?   A . n 
A 1 31  SER 31  -1  ?   ?   ?   A . n 
A 1 32  MET 32  0   ?   ?   ?   A . n 
A 1 33  VAL 33  1   ?   ?   ?   A . n 
A 1 34  SER 34  2   ?   ?   ?   A . n 
A 1 35  LYS 35  3   ?   ?   ?   A . n 
A 1 36  GLY 36  4   ?   ?   ?   A . n 
A 1 37  GLU 37  5   ?   ?   ?   A . n 
A 1 38  GLU 38  6   6   GLU GLU A . n 
A 1 39  VAL 39  7   7   VAL VAL A . n 
A 1 40  ILE 40  8   8   ILE ILE A . n 
A 1 41  LYS 41  9   9   LYS LYS A . n 
A 1 42  GLU 42  10  10  GLU GLU A . n 
A 1 43  PHE 43  11  11  PHE PHE A . n 
A 1 44  MET 44  12  12  MET MET A . n 
A 1 45  ARG 45  13  13  ARG ARG A . n 
A 1 46  PHE 46  14  14  PHE PHE A . n 
A 1 47  LYS 47  15  15  LYS LYS A . n 
A 1 48  GLU 48  16  16  GLU GLU A . n 
A 1 49  HIS 49  17  17  HIS HIS A . n 
A 1 50  MET 50  18  18  MET MET A . n 
A 1 51  GLU 51  19  19  GLU GLU A . n 
A 1 52  GLY 52  20  20  GLY GLY A . n 
A 1 53  SER 53  21  21  SER SER A . n 
A 1 54  VAL 54  22  22  VAL VAL A . n 
A 1 55  ASN 55  23  23  ASN ASN A . n 
A 1 56  GLY 56  24  24  GLY GLY A . n 
A 1 57  HIS 57  25  25  HIS HIS A . n 
A 1 58  GLU 58  26  26  GLU GLU A . n 
A 1 59  PHE 59  27  27  PHE PHE A . n 
A 1 60  GLU 60  28  28  GLU GLU A . n 
A 1 61  ILE 61  29  29  ILE ILE A . n 
A 1 62  GLU 62  30  30  GLU GLU A . n 
A 1 63  GLY 63  31  31  GLY GLY A . n 
A 1 64  GLU 64  32  32  GLU GLU A . n 
A 1 65  GLY 65  33  33  GLY GLY A . n 
A 1 66  GLU 66  34  34  GLU GLU A . n 
A 1 67  GLY 67  35  35  GLY GLY A . n 
A 1 68  ARG 68  36  36  ARG ARG A . n 
A 1 69  PRO 69  37  37  PRO PRO A . n 
A 1 70  TYR 70  38  38  TYR TYR A . n 
A 1 71  GLU 71  39  39  GLU GLU A . n 
A 1 72  GLY 72  40  40  GLY GLY A . n 
A 1 73  THR 73  41  41  THR THR A . n 
A 1 74  GLN 74  42  42  GLN GLN A . n 
A 1 75  THR 75  43  43  THR THR A . n 
A 1 76  ALA 76  44  44  ALA ALA A . n 
A 1 77  ARG 77  45  45  ARG ARG A . n 
A 1 78  LEU 78  46  46  LEU LEU A . n 
A 1 79  LYS 79  47  47  LYS LYS A . n 
A 1 80  VAL 80  48  48  VAL VAL A . n 
A 1 81  THR 81  49  49  THR THR A . n 
A 1 82  LYS 82  50  50  LYS LYS A . n 
A 1 83  GLY 83  51  51  GLY GLY A . n 
A 1 84  GLY 84  52  52  GLY GLY A . n 
A 1 85  PRO 85  53  53  PRO PRO A . n 
A 1 86  LEU 86  54  54  LEU LEU A . n 
A 1 87  PRO 87  55  55  PRO PRO A . n 
A 1 88  PHE 88  56  56  PHE PHE A . n 
A 1 89  ALA 89  57  57  ALA ALA A . n 
A 1 90  TRP 90  58  58  TRP TRP A . n 
A 1 91  ASP 91  59  59  ASP ASP A . n 
A 1 92  ILE 92  60  60  ILE ILE A . n 
A 1 93  LEU 93  61  61  LEU LEU A . n 
A 1 94  SER 94  62  62  SER SER A . n 
A 1 95  PRO 95  63  63  PRO PRO A . n 
A 1 96  GLN 96  64  64  GLN GLN A . n 
A 1 97  ILE 97  65  65  ILE ILE A . n 
A 1 98  MET 98  65  ?   ?   ?   A A n 
A 1 99  TYR 99  65  ?   ?   ?   A B n 
A 1 100 GLY 100 65  ?   ?   ?   A C n 
A 1 101 CH6 101 68  68  CH6 CH6 A . n 
A 1 102 SER 102 69  69  SER SER A . n 
A 1 103 LYS 103 70  70  LYS LYS A . n 
A 1 104 ALA 104 71  71  ALA ALA A . n 
A 1 105 TYR 105 72  72  TYR TYR A . n 
A 1 106 VAL 106 73  73  VAL VAL A . n 
A 1 107 LYS 107 74  74  LYS LYS A . n 
A 1 108 HIS 108 75  75  HIS HIS A . n 
A 1 109 PRO 109 76  76  PRO PRO A . n 
A 1 110 ALA 110 77  77  ALA ALA A . n 
A 1 111 ASP 111 78  78  ASP ASP A . n 
A 1 112 ILE 112 79  79  ILE ILE A . n 
A 1 113 PRO 113 80  80  PRO PRO A . n 
A 1 114 ASP 114 81  81  ASP ASP A . n 
A 1 115 TYR 115 82  82  TYR TYR A . n 
A 1 116 LEU 116 83  83  LEU LEU A . n 
A 1 117 LYS 117 84  84  LYS LYS A . n 
A 1 118 LEU 118 85  85  LEU LEU A . n 
A 1 119 SER 119 86  86  SER SER A . n 
A 1 120 PHE 120 87  87  PHE PHE A . n 
A 1 121 PRO 121 88  88  PRO PRO A . n 
A 1 122 GLU 122 89  89  GLU GLU A . n 
A 1 123 GLY 123 90  90  GLY GLY A . n 
A 1 124 PHE 124 91  91  PHE PHE A . n 
A 1 125 LYS 125 92  92  LYS LYS A . n 
A 1 126 TRP 126 93  93  TRP TRP A . n 
A 1 127 GLU 127 94  94  GLU GLU A . n 
A 1 128 ARG 128 95  95  ARG ARG A . n 
A 1 129 VAL 129 96  96  VAL VAL A . n 
A 1 130 MET 130 97  97  MET MET A . n 
A 1 131 ASN 131 98  98  ASN ASN A . n 
A 1 132 PHE 132 99  99  PHE PHE A . n 
A 1 133 GLU 133 100 100 GLU GLU A . n 
A 1 134 ASP 134 101 101 ASP ASP A . n 
A 1 135 GLY 135 102 102 GLY GLY A . n 
A 1 136 GLY 136 103 103 GLY GLY A . n 
A 1 137 VAL 137 104 104 VAL VAL A . n 
A 1 138 VAL 138 105 105 VAL VAL A . n 
A 1 139 THR 139 106 106 THR THR A . n 
A 1 140 VAL 140 107 107 VAL VAL A . n 
A 1 141 THR 141 108 108 THR THR A . n 
A 1 142 GLN 142 109 109 GLN GLN A . n 
A 1 143 ASP 143 110 110 ASP ASP A . n 
A 1 144 SER 144 111 111 SER SER A . n 
A 1 145 SER 145 112 112 SER SER A . n 
A 1 146 LEU 146 113 113 LEU LEU A . n 
A 1 147 GLN 147 114 114 GLN GLN A . n 
A 1 148 ASP 148 115 115 ASP ASP A . n 
A 1 149 GLY 149 116 116 GLY GLY A . n 
A 1 150 GLU 150 117 117 GLU GLU A . n 
A 1 151 PHE 151 118 118 PHE PHE A . n 
A 1 152 ILE 152 119 119 ILE ILE A . n 
A 1 153 TYR 153 120 120 TYR TYR A . n 
A 1 154 LYS 154 121 121 LYS LYS A . n 
A 1 155 VAL 155 122 122 VAL VAL A . n 
A 1 156 LYS 156 123 123 LYS LYS A . n 
A 1 157 VAL 157 124 124 VAL VAL A . n 
A 1 158 ARG 158 125 125 ARG ARG A . n 
A 1 159 GLY 159 126 126 GLY GLY A . n 
A 1 160 THR 160 127 127 THR THR A . n 
A 1 161 ASN 161 128 128 ASN ASN A . n 
A 1 162 PHE 162 129 129 PHE PHE A . n 
A 1 163 PRO 163 130 130 PRO PRO A . n 
A 1 164 SER 164 131 131 SER SER A . n 
A 1 165 ASP 165 132 132 ASP ASP A . n 
A 1 166 GLY 166 133 133 GLY GLY A . n 
A 1 167 PRO 167 134 134 PRO PRO A . n 
A 1 168 VAL 168 135 135 VAL VAL A . n 
A 1 169 MET 169 136 136 MET MET A . n 
A 1 170 GLN 170 137 137 GLN GLN A . n 
A 1 171 LYS 171 138 138 LYS LYS A . n 
A 1 172 LYS 172 139 139 LYS LYS A . n 
A 1 173 THR 173 140 140 THR THR A . n 
A 1 174 MET 174 141 141 MET MET A . n 
A 1 175 GLY 175 142 142 GLY GLY A . n 
A 1 176 TRP 176 143 143 TRP TRP A . n 
A 1 177 GLU 177 144 144 GLU GLU A . n 
A 1 178 ALA 178 145 145 ALA ALA A . n 
A 1 179 SER 179 146 146 SER SER A . n 
A 1 180 SER 180 147 147 SER SER A . n 
A 1 181 GLU 181 148 148 GLU GLU A . n 
A 1 182 ARG 182 149 149 ARG ARG A . n 
A 1 183 MET 183 150 150 MET MET A . n 
A 1 184 TYR 184 151 151 TYR TYR A . n 
A 1 185 PRO 185 152 152 PRO PRO A . n 
A 1 186 GLU 186 153 153 GLU GLU A . n 
A 1 187 ASP 187 154 154 ASP ASP A . n 
A 1 188 GLY 188 155 155 GLY GLY A . n 
A 1 189 ALA 189 156 156 ALA ALA A . n 
A 1 190 LEU 190 157 157 LEU LEU A . n 
A 1 191 LYS 191 158 158 LYS LYS A . n 
A 1 192 GLY 192 159 159 GLY GLY A . n 
A 1 193 GLU 193 160 160 GLU GLU A . n 
A 1 194 MET 194 161 161 MET MET A . n 
A 1 195 LYS 195 162 162 LYS LYS A . n 
A 1 196 MET 196 163 163 MET MET A . n 
A 1 197 ARG 197 164 164 ARG ARG A . n 
A 1 198 LEU 198 165 165 LEU LEU A . n 
A 1 199 ARG 199 166 166 ARG ARG A . n 
A 1 200 LEU 200 167 167 LEU LEU A . n 
A 1 201 LYS 201 168 168 LYS LYS A . n 
A 1 202 ASP 202 169 169 ASP ASP A . n 
A 1 203 GLY 203 170 170 GLY GLY A . n 
A 1 204 GLY 204 171 171 GLY GLY A . n 
A 1 205 HIS 205 172 172 HIS HIS A . n 
A 1 206 TYR 206 173 173 TYR TYR A . n 
A 1 207 ASP 207 174 174 ASP ASP A . n 
A 1 208 ALA 208 175 175 ALA ALA A . n 
A 1 209 GLU 209 176 176 GLU GLU A . n 
A 1 210 VAL 210 177 177 VAL VAL A . n 
A 1 211 LYS 211 178 178 LYS LYS A . n 
A 1 212 THR 212 179 179 THR THR A . n 
A 1 213 THR 213 180 180 THR THR A . n 
A 1 214 TYR 214 181 181 TYR TYR A . n 
A 1 215 MET 215 182 182 MET MET A . n 
A 1 216 ALA 216 183 183 ALA ALA A . n 
A 1 217 LYS 217 184 184 LYS LYS A . n 
A 1 218 LYS 218 185 185 LYS LYS A . n 
A 1 219 PRO 219 186 186 PRO PRO A . n 
A 1 220 VAL 220 187 187 VAL VAL A . n 
A 1 221 GLN 221 188 188 GLN GLN A . n 
A 1 222 LEU 222 189 189 LEU LEU A . n 
A 1 223 PRO 223 190 190 PRO PRO A . n 
A 1 224 GLY 224 191 191 GLY GLY A . n 
A 1 225 ALA 225 192 192 ALA ALA A . n 
A 1 226 TYR 226 193 193 TYR TYR A . n 
A 1 227 LYS 227 194 194 LYS LYS A . n 
A 1 228 THR 228 195 195 THR THR A . n 
A 1 229 ASP 229 196 196 ASP ASP A . n 
A 1 230 ILE 230 197 197 ILE ILE A . n 
A 1 231 LYS 231 198 198 LYS LYS A . n 
A 1 232 LEU 232 199 199 LEU LEU A . n 
A 1 233 ASP 233 200 200 ASP ASP A . n 
A 1 234 ILE 234 201 201 ILE ILE A . n 
A 1 235 THR 235 202 202 THR THR A . n 
A 1 236 SER 236 203 203 SER SER A . n 
A 1 237 HIS 237 204 204 HIS HIS A . n 
A 1 238 ASN 238 205 205 ASN ASN A . n 
A 1 239 GLU 239 206 206 GLU GLU A . n 
A 1 240 ASP 240 207 207 ASP ASP A . n 
A 1 241 TYR 241 208 208 TYR TYR A . n 
A 1 242 THR 242 209 209 THR THR A . n 
A 1 243 ILE 243 210 210 ILE ILE A . n 
A 1 244 VAL 244 211 211 VAL VAL A . n 
A 1 245 GLU 245 212 212 GLU GLU A . n 
A 1 246 GLN 246 213 213 GLN GLN A . n 
A 1 247 TYR 247 214 214 TYR TYR A . n 
A 1 248 GLU 248 215 215 GLU GLU A . n 
A 1 249 ARG 249 216 216 ARG ARG A . n 
A 1 250 ALA 250 217 217 ALA ALA A . n 
A 1 251 GLU 251 218 218 GLU GLU A . n 
A 1 252 GLY 252 219 219 GLY GLY A . n 
A 1 253 ARG 253 220 220 ARG ARG A . n 
A 1 254 HIS 254 221 221 HIS HIS A . n 
A 1 255 SER 255 222 222 SER SER A . n 
A 1 256 THR 256 223 223 THR THR A . n 
A 1 257 GLY 257 224 224 GLY GLY A . n 
A 1 258 ALA 258 225 ?   ?   ?   A . n 
B 1 1   HIS 1   -31 ?   ?   ?   B . n 
B 1 2   HIS 2   -30 ?   ?   ?   B . n 
B 1 3   HIS 3   -29 ?   ?   ?   B . n 
B 1 4   HIS 4   -28 ?   ?   ?   B . n 
B 1 5   HIS 5   -27 ?   ?   ?   B . n 
B 1 6   HIS 6   -26 ?   ?   ?   B . n 
B 1 7   GLY 7   -25 ?   ?   ?   B . n 
B 1 8   MET 8   -24 ?   ?   ?   B . n 
B 1 9   ALA 9   -23 ?   ?   ?   B . n 
B 1 10  SER 10  -22 ?   ?   ?   B . n 
B 1 11  MET 11  -21 ?   ?   ?   B . n 
B 1 12  THR 12  -20 ?   ?   ?   B . n 
B 1 13  GLY 13  -19 ?   ?   ?   B . n 
B 1 14  GLY 14  -18 ?   ?   ?   B . n 
B 1 15  GLN 15  -17 ?   ?   ?   B . n 
B 1 16  GLN 16  -16 ?   ?   ?   B . n 
B 1 17  MET 17  -15 ?   ?   ?   B . n 
B 1 18  GLY 18  -14 ?   ?   ?   B . n 
B 1 19  ARG 19  -13 ?   ?   ?   B . n 
B 1 20  ASP 20  -12 ?   ?   ?   B . n 
B 1 21  LEU 21  -11 ?   ?   ?   B . n 
B 1 22  TYR 22  -10 ?   ?   ?   B . n 
B 1 23  GLU 23  -9  ?   ?   ?   B . n 
B 1 24  ASN 24  -8  ?   ?   ?   B . n 
B 1 25  LEU 25  -7  ?   ?   ?   B . n 
B 1 26  TYR 26  -6  ?   ?   ?   B . n 
B 1 27  PHE 27  -5  ?   ?   ?   B . n 
B 1 28  GLN 28  -4  ?   ?   ?   B . n 
B 1 29  GLY 29  -3  ?   ?   ?   B . n 
B 1 30  SER 30  -2  ?   ?   ?   B . n 
B 1 31  SER 31  -1  ?   ?   ?   B . n 
B 1 32  MET 32  0   ?   ?   ?   B . n 
B 1 33  VAL 33  1   ?   ?   ?   B . n 
B 1 34  SER 34  2   ?   ?   ?   B . n 
B 1 35  LYS 35  3   ?   ?   ?   B . n 
B 1 36  GLY 36  4   ?   ?   ?   B . n 
B 1 37  GLU 37  5   ?   ?   ?   B . n 
B 1 38  GLU 38  6   6   GLU GLU B . n 
B 1 39  VAL 39  7   7   VAL VAL B . n 
B 1 40  ILE 40  8   8   ILE ILE B . n 
B 1 41  LYS 41  9   9   LYS LYS B . n 
B 1 42  GLU 42  10  10  GLU GLU B . n 
B 1 43  PHE 43  11  11  PHE PHE B . n 
B 1 44  MET 44  12  12  MET MET B . n 
B 1 45  ARG 45  13  13  ARG ARG B . n 
B 1 46  PHE 46  14  14  PHE PHE B . n 
B 1 47  LYS 47  15  15  LYS LYS B . n 
B 1 48  GLU 48  16  16  GLU GLU B . n 
B 1 49  HIS 49  17  17  HIS HIS B . n 
B 1 50  MET 50  18  18  MET MET B . n 
B 1 51  GLU 51  19  19  GLU GLU B . n 
B 1 52  GLY 52  20  20  GLY GLY B . n 
B 1 53  SER 53  21  21  SER SER B . n 
B 1 54  VAL 54  22  22  VAL VAL B . n 
B 1 55  ASN 55  23  23  ASN ASN B . n 
B 1 56  GLY 56  24  24  GLY GLY B . n 
B 1 57  HIS 57  25  25  HIS HIS B . n 
B 1 58  GLU 58  26  26  GLU GLU B . n 
B 1 59  PHE 59  27  27  PHE PHE B . n 
B 1 60  GLU 60  28  28  GLU GLU B . n 
B 1 61  ILE 61  29  29  ILE ILE B . n 
B 1 62  GLU 62  30  30  GLU GLU B . n 
B 1 63  GLY 63  31  31  GLY GLY B . n 
B 1 64  GLU 64  32  32  GLU GLU B . n 
B 1 65  GLY 65  33  33  GLY GLY B . n 
B 1 66  GLU 66  34  34  GLU GLU B . n 
B 1 67  GLY 67  35  35  GLY GLY B . n 
B 1 68  ARG 68  36  36  ARG ARG B . n 
B 1 69  PRO 69  37  37  PRO PRO B . n 
B 1 70  TYR 70  38  38  TYR TYR B . n 
B 1 71  GLU 71  39  39  GLU GLU B . n 
B 1 72  GLY 72  40  40  GLY GLY B . n 
B 1 73  THR 73  41  41  THR THR B . n 
B 1 74  GLN 74  42  42  GLN GLN B . n 
B 1 75  THR 75  43  43  THR THR B . n 
B 1 76  ALA 76  44  44  ALA ALA B . n 
B 1 77  ARG 77  45  45  ARG ARG B . n 
B 1 78  LEU 78  46  46  LEU LEU B . n 
B 1 79  LYS 79  47  47  LYS LYS B . n 
B 1 80  VAL 80  48  48  VAL VAL B . n 
B 1 81  THR 81  49  49  THR THR B . n 
B 1 82  LYS 82  50  50  LYS LYS B . n 
B 1 83  GLY 83  51  51  GLY GLY B . n 
B 1 84  GLY 84  52  52  GLY GLY B . n 
B 1 85  PRO 85  53  53  PRO PRO B . n 
B 1 86  LEU 86  54  54  LEU LEU B . n 
B 1 87  PRO 87  55  55  PRO PRO B . n 
B 1 88  PHE 88  56  56  PHE PHE B . n 
B 1 89  ALA 89  57  57  ALA ALA B . n 
B 1 90  TRP 90  58  58  TRP TRP B . n 
B 1 91  ASP 91  59  59  ASP ASP B . n 
B 1 92  ILE 92  60  60  ILE ILE B . n 
B 1 93  LEU 93  61  61  LEU LEU B . n 
B 1 94  SER 94  62  62  SER SER B . n 
B 1 95  PRO 95  63  63  PRO PRO B . n 
B 1 96  GLN 96  64  64  GLN GLN B . n 
B 1 97  ILE 97  65  65  ILE ILE B . n 
B 1 98  MET 98  65  ?   ?   ?   B A n 
B 1 99  TYR 99  65  ?   ?   ?   B B n 
B 1 100 GLY 100 65  ?   ?   ?   B C n 
B 1 101 CH6 101 68  68  CH6 CH6 B . n 
B 1 102 SER 102 69  69  SER SER B . n 
B 1 103 LYS 103 70  70  LYS LYS B . n 
B 1 104 ALA 104 71  71  ALA ALA B . n 
B 1 105 TYR 105 72  72  TYR TYR B . n 
B 1 106 VAL 106 73  73  VAL VAL B . n 
B 1 107 LYS 107 74  74  LYS LYS B . n 
B 1 108 HIS 108 75  75  HIS HIS B . n 
B 1 109 PRO 109 76  76  PRO PRO B . n 
B 1 110 ALA 110 77  77  ALA ALA B . n 
B 1 111 ASP 111 78  78  ASP ASP B . n 
B 1 112 ILE 112 79  79  ILE ILE B . n 
B 1 113 PRO 113 80  80  PRO PRO B . n 
B 1 114 ASP 114 81  81  ASP ASP B . n 
B 1 115 TYR 115 82  82  TYR TYR B . n 
B 1 116 LEU 116 83  83  LEU LEU B . n 
B 1 117 LYS 117 84  84  LYS LYS B . n 
B 1 118 LEU 118 85  85  LEU LEU B . n 
B 1 119 SER 119 86  86  SER SER B . n 
B 1 120 PHE 120 87  87  PHE PHE B . n 
B 1 121 PRO 121 88  88  PRO PRO B . n 
B 1 122 GLU 122 89  89  GLU GLU B . n 
B 1 123 GLY 123 90  90  GLY GLY B . n 
B 1 124 PHE 124 91  91  PHE PHE B . n 
B 1 125 LYS 125 92  92  LYS LYS B . n 
B 1 126 TRP 126 93  93  TRP TRP B . n 
B 1 127 GLU 127 94  94  GLU GLU B . n 
B 1 128 ARG 128 95  95  ARG ARG B . n 
B 1 129 VAL 129 96  96  VAL VAL B . n 
B 1 130 MET 130 97  97  MET MET B . n 
B 1 131 ASN 131 98  98  ASN ASN B . n 
B 1 132 PHE 132 99  99  PHE PHE B . n 
B 1 133 GLU 133 100 100 GLU GLU B . n 
B 1 134 ASP 134 101 101 ASP ASP B . n 
B 1 135 GLY 135 102 102 GLY GLY B . n 
B 1 136 GLY 136 103 103 GLY GLY B . n 
B 1 137 VAL 137 104 104 VAL VAL B . n 
B 1 138 VAL 138 105 105 VAL VAL B . n 
B 1 139 THR 139 106 106 THR THR B . n 
B 1 140 VAL 140 107 107 VAL VAL B . n 
B 1 141 THR 141 108 108 THR THR B . n 
B 1 142 GLN 142 109 109 GLN GLN B . n 
B 1 143 ASP 143 110 110 ASP ASP B . n 
B 1 144 SER 144 111 111 SER SER B . n 
B 1 145 SER 145 112 112 SER SER B . n 
B 1 146 LEU 146 113 113 LEU LEU B . n 
B 1 147 GLN 147 114 114 GLN GLN B . n 
B 1 148 ASP 148 115 115 ASP ASP B . n 
B 1 149 GLY 149 116 116 GLY GLY B . n 
B 1 150 GLU 150 117 117 GLU GLU B . n 
B 1 151 PHE 151 118 118 PHE PHE B . n 
B 1 152 ILE 152 119 119 ILE ILE B . n 
B 1 153 TYR 153 120 120 TYR TYR B . n 
B 1 154 LYS 154 121 121 LYS LYS B . n 
B 1 155 VAL 155 122 122 VAL VAL B . n 
B 1 156 LYS 156 123 123 LYS LYS B . n 
B 1 157 VAL 157 124 124 VAL VAL B . n 
B 1 158 ARG 158 125 125 ARG ARG B . n 
B 1 159 GLY 159 126 126 GLY GLY B . n 
B 1 160 THR 160 127 127 THR THR B . n 
B 1 161 ASN 161 128 128 ASN ASN B . n 
B 1 162 PHE 162 129 129 PHE PHE B . n 
B 1 163 PRO 163 130 130 PRO PRO B . n 
B 1 164 SER 164 131 131 SER SER B . n 
B 1 165 ASP 165 132 132 ASP ASP B . n 
B 1 166 GLY 166 133 133 GLY GLY B . n 
B 1 167 PRO 167 134 134 PRO PRO B . n 
B 1 168 VAL 168 135 135 VAL VAL B . n 
B 1 169 MET 169 136 136 MET MET B . n 
B 1 170 GLN 170 137 137 GLN GLN B . n 
B 1 171 LYS 171 138 138 LYS LYS B . n 
B 1 172 LYS 172 139 139 LYS LYS B . n 
B 1 173 THR 173 140 140 THR THR B . n 
B 1 174 MET 174 141 141 MET MET B . n 
B 1 175 GLY 175 142 142 GLY GLY B . n 
B 1 176 TRP 176 143 143 TRP TRP B . n 
B 1 177 GLU 177 144 144 GLU GLU B . n 
B 1 178 ALA 178 145 145 ALA ALA B . n 
B 1 179 SER 179 146 146 SER SER B . n 
B 1 180 SER 180 147 147 SER SER B . n 
B 1 181 GLU 181 148 148 GLU GLU B . n 
B 1 182 ARG 182 149 149 ARG ARG B . n 
B 1 183 MET 183 150 150 MET MET B . n 
B 1 184 TYR 184 151 151 TYR TYR B . n 
B 1 185 PRO 185 152 152 PRO PRO B . n 
B 1 186 GLU 186 153 153 GLU GLU B . n 
B 1 187 ASP 187 154 154 ASP ASP B . n 
B 1 188 GLY 188 155 155 GLY GLY B . n 
B 1 189 ALA 189 156 156 ALA ALA B . n 
B 1 190 LEU 190 157 157 LEU LEU B . n 
B 1 191 LYS 191 158 158 LYS LYS B . n 
B 1 192 GLY 192 159 159 GLY GLY B . n 
B 1 193 GLU 193 160 160 GLU GLU B . n 
B 1 194 MET 194 161 161 MET MET B . n 
B 1 195 LYS 195 162 162 LYS LYS B . n 
B 1 196 MET 196 163 163 MET MET B . n 
B 1 197 ARG 197 164 164 ARG ARG B . n 
B 1 198 LEU 198 165 165 LEU LEU B . n 
B 1 199 ARG 199 166 166 ARG ARG B . n 
B 1 200 LEU 200 167 167 LEU LEU B . n 
B 1 201 LYS 201 168 168 LYS LYS B . n 
B 1 202 ASP 202 169 169 ASP ASP B . n 
B 1 203 GLY 203 170 170 GLY GLY B . n 
B 1 204 GLY 204 171 171 GLY GLY B . n 
B 1 205 HIS 205 172 172 HIS HIS B . n 
B 1 206 TYR 206 173 173 TYR TYR B . n 
B 1 207 ASP 207 174 174 ASP ASP B . n 
B 1 208 ALA 208 175 175 ALA ALA B . n 
B 1 209 GLU 209 176 176 GLU GLU B . n 
B 1 210 VAL 210 177 177 VAL VAL B . n 
B 1 211 LYS 211 178 178 LYS LYS B . n 
B 1 212 THR 212 179 179 THR THR B . n 
B 1 213 THR 213 180 180 THR THR B . n 
B 1 214 TYR 214 181 181 TYR TYR B . n 
B 1 215 MET 215 182 182 MET MET B . n 
B 1 216 ALA 216 183 183 ALA ALA B . n 
B 1 217 LYS 217 184 184 LYS LYS B . n 
B 1 218 LYS 218 185 185 LYS LYS B . n 
B 1 219 PRO 219 186 186 PRO PRO B . n 
B 1 220 VAL 220 187 187 VAL VAL B . n 
B 1 221 GLN 221 188 188 GLN GLN B . n 
B 1 222 LEU 222 189 189 LEU LEU B . n 
B 1 223 PRO 223 190 190 PRO PRO B . n 
B 1 224 GLY 224 191 191 GLY GLY B . n 
B 1 225 ALA 225 192 192 ALA ALA B . n 
B 1 226 TYR 226 193 193 TYR TYR B . n 
B 1 227 LYS 227 194 194 LYS LYS B . n 
B 1 228 THR 228 195 195 THR THR B . n 
B 1 229 ASP 229 196 196 ASP ASP B . n 
B 1 230 ILE 230 197 197 ILE ILE B . n 
B 1 231 LYS 231 198 198 LYS LYS B . n 
B 1 232 LEU 232 199 199 LEU LEU B . n 
B 1 233 ASP 233 200 200 ASP ASP B . n 
B 1 234 ILE 234 201 201 ILE ILE B . n 
B 1 235 THR 235 202 202 THR THR B . n 
B 1 236 SER 236 203 203 SER SER B . n 
B 1 237 HIS 237 204 204 HIS HIS B . n 
B 1 238 ASN 238 205 205 ASN ASN B . n 
B 1 239 GLU 239 206 206 GLU GLU B . n 
B 1 240 ASP 240 207 207 ASP ASP B . n 
B 1 241 TYR 241 208 208 TYR TYR B . n 
B 1 242 THR 242 209 209 THR THR B . n 
B 1 243 ILE 243 210 210 ILE ILE B . n 
B 1 244 VAL 244 211 211 VAL VAL B . n 
B 1 245 GLU 245 212 212 GLU GLU B . n 
B 1 246 GLN 246 213 213 GLN GLN B . n 
B 1 247 TYR 247 214 214 TYR TYR B . n 
B 1 248 GLU 248 215 215 GLU GLU B . n 
B 1 249 ARG 249 216 216 ARG ARG B . n 
B 1 250 ALA 250 217 217 ALA ALA B . n 
B 1 251 GLU 251 218 218 GLU GLU B . n 
B 1 252 GLY 252 219 219 GLY GLY B . n 
B 1 253 ARG 253 220 220 ARG ARG B . n 
B 1 254 HIS 254 221 221 HIS HIS B . n 
B 1 255 SER 255 222 222 SER SER B . n 
B 1 256 THR 256 223 223 THR THR B . n 
B 1 257 GLY 257 224 224 GLY GLY B . n 
B 1 258 ALA 258 225 225 ALA ALA B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CH6 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CH6 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 HOH 1   301 142 HOH HOH A . 
C 2 HOH 2   302 213 HOH HOH A . 
C 2 HOH 3   303 296 HOH HOH A . 
C 2 HOH 4   304 327 HOH HOH A . 
C 2 HOH 5   305 332 HOH HOH A . 
C 2 HOH 6   306 266 HOH HOH A . 
C 2 HOH 7   307 200 HOH HOH A . 
C 2 HOH 8   308 21  HOH HOH A . 
C 2 HOH 9   309 304 HOH HOH A . 
C 2 HOH 10  310 192 HOH HOH A . 
C 2 HOH 11  311 286 HOH HOH A . 
C 2 HOH 12  312 269 HOH HOH A . 
C 2 HOH 13  313 277 HOH HOH A . 
C 2 HOH 14  314 133 HOH HOH A . 
C 2 HOH 15  315 24  HOH HOH A . 
C 2 HOH 16  316 125 HOH HOH A . 
C 2 HOH 17  317 178 HOH HOH A . 
C 2 HOH 18  318 119 HOH HOH A . 
C 2 HOH 19  319 116 HOH HOH A . 
C 2 HOH 20  320 84  HOH HOH A . 
C 2 HOH 21  321 111 HOH HOH A . 
C 2 HOH 22  322 258 HOH HOH A . 
C 2 HOH 23  323 264 HOH HOH A . 
C 2 HOH 24  324 325 HOH HOH A . 
C 2 HOH 25  325 23  HOH HOH A . 
C 2 HOH 26  326 63  HOH HOH A . 
C 2 HOH 27  327 128 HOH HOH A . 
C 2 HOH 28  328 54  HOH HOH A . 
C 2 HOH 29  329 187 HOH HOH A . 
C 2 HOH 30  330 321 HOH HOH A . 
C 2 HOH 31  331 232 HOH HOH A . 
C 2 HOH 32  332 87  HOH HOH A . 
C 2 HOH 33  333 20  HOH HOH A . 
C 2 HOH 34  334 305 HOH HOH A . 
C 2 HOH 35  335 271 HOH HOH A . 
C 2 HOH 36  336 174 HOH HOH A . 
C 2 HOH 37  337 287 HOH HOH A . 
C 2 HOH 38  338 310 HOH HOH A . 
C 2 HOH 39  339 267 HOH HOH A . 
C 2 HOH 40  340 69  HOH HOH A . 
C 2 HOH 41  341 55  HOH HOH A . 
C 2 HOH 42  342 11  HOH HOH A . 
C 2 HOH 43  343 145 HOH HOH A . 
C 2 HOH 44  344 7   HOH HOH A . 
C 2 HOH 45  345 6   HOH HOH A . 
C 2 HOH 46  346 101 HOH HOH A . 
C 2 HOH 47  347 222 HOH HOH A . 
C 2 HOH 48  348 148 HOH HOH A . 
C 2 HOH 49  349 108 HOH HOH A . 
C 2 HOH 50  350 90  HOH HOH A . 
C 2 HOH 51  351 117 HOH HOH A . 
C 2 HOH 52  352 70  HOH HOH A . 
C 2 HOH 53  353 272 HOH HOH A . 
C 2 HOH 54  354 281 HOH HOH A . 
C 2 HOH 55  355 18  HOH HOH A . 
C 2 HOH 56  356 194 HOH HOH A . 
C 2 HOH 57  357 29  HOH HOH A . 
C 2 HOH 58  358 242 HOH HOH A . 
C 2 HOH 59  359 74  HOH HOH A . 
C 2 HOH 60  360 66  HOH HOH A . 
C 2 HOH 61  361 121 HOH HOH A . 
C 2 HOH 62  362 27  HOH HOH A . 
C 2 HOH 63  363 265 HOH HOH A . 
C 2 HOH 64  364 210 HOH HOH A . 
C 2 HOH 65  365 198 HOH HOH A . 
C 2 HOH 66  366 8   HOH HOH A . 
C 2 HOH 67  367 59  HOH HOH A . 
C 2 HOH 68  368 79  HOH HOH A . 
C 2 HOH 69  369 180 HOH HOH A . 
C 2 HOH 70  370 179 HOH HOH A . 
C 2 HOH 71  371 253 HOH HOH A . 
C 2 HOH 72  372 154 HOH HOH A . 
C 2 HOH 73  373 15  HOH HOH A . 
C 2 HOH 74  374 49  HOH HOH A . 
C 2 HOH 75  375 215 HOH HOH A . 
C 2 HOH 76  376 47  HOH HOH A . 
C 2 HOH 77  377 105 HOH HOH A . 
C 2 HOH 78  378 184 HOH HOH A . 
C 2 HOH 79  379 35  HOH HOH A . 
C 2 HOH 80  380 251 HOH HOH A . 
C 2 HOH 81  381 68  HOH HOH A . 
C 2 HOH 82  382 255 HOH HOH A . 
C 2 HOH 83  383 42  HOH HOH A . 
C 2 HOH 84  384 30  HOH HOH A . 
C 2 HOH 85  385 65  HOH HOH A . 
C 2 HOH 86  386 45  HOH HOH A . 
C 2 HOH 87  387 274 HOH HOH A . 
C 2 HOH 88  388 100 HOH HOH A . 
C 2 HOH 89  389 201 HOH HOH A . 
C 2 HOH 90  390 138 HOH HOH A . 
C 2 HOH 91  391 256 HOH HOH A . 
C 2 HOH 92  392 275 HOH HOH A . 
C 2 HOH 93  393 167 HOH HOH A . 
C 2 HOH 94  394 46  HOH HOH A . 
C 2 HOH 95  395 123 HOH HOH A . 
C 2 HOH 96  396 221 HOH HOH A . 
C 2 HOH 97  397 270 HOH HOH A . 
C 2 HOH 98  398 207 HOH HOH A . 
C 2 HOH 99  399 57  HOH HOH A . 
C 2 HOH 100 400 52  HOH HOH A . 
C 2 HOH 101 401 214 HOH HOH A . 
C 2 HOH 102 402 196 HOH HOH A . 
C 2 HOH 103 403 127 HOH HOH A . 
C 2 HOH 104 404 159 HOH HOH A . 
C 2 HOH 105 405 82  HOH HOH A . 
C 2 HOH 106 406 89  HOH HOH A . 
C 2 HOH 107 407 261 HOH HOH A . 
C 2 HOH 108 408 94  HOH HOH A . 
C 2 HOH 109 409 114 HOH HOH A . 
C 2 HOH 110 410 188 HOH HOH A . 
C 2 HOH 111 411 324 HOH HOH A . 
C 2 HOH 112 412 257 HOH HOH A . 
C 2 HOH 113 413 34  HOH HOH A . 
C 2 HOH 114 414 143 HOH HOH A . 
C 2 HOH 115 415 248 HOH HOH A . 
C 2 HOH 116 416 77  HOH HOH A . 
C 2 HOH 117 417 319 HOH HOH A . 
C 2 HOH 118 418 241 HOH HOH A . 
C 2 HOH 119 419 282 HOH HOH A . 
C 2 HOH 120 420 199 HOH HOH A . 
C 2 HOH 121 421 37  HOH HOH A . 
C 2 HOH 122 422 95  HOH HOH A . 
C 2 HOH 123 423 189 HOH HOH A . 
C 2 HOH 124 424 36  HOH HOH A . 
C 2 HOH 125 425 10  HOH HOH A . 
C 2 HOH 126 426 31  HOH HOH A . 
C 2 HOH 127 427 209 HOH HOH A . 
C 2 HOH 128 428 53  HOH HOH A . 
C 2 HOH 129 429 44  HOH HOH A . 
C 2 HOH 130 430 331 HOH HOH A . 
C 2 HOH 131 431 284 HOH HOH A . 
C 2 HOH 132 432 99  HOH HOH A . 
C 2 HOH 133 433 292 HOH HOH A . 
C 2 HOH 134 434 177 HOH HOH A . 
C 2 HOH 135 435 93  HOH HOH A . 
C 2 HOH 136 436 318 HOH HOH A . 
C 2 HOH 137 437 226 HOH HOH A . 
C 2 HOH 138 438 223 HOH HOH A . 
C 2 HOH 139 439 252 HOH HOH A . 
C 2 HOH 140 440 326 HOH HOH A . 
C 2 HOH 141 441 204 HOH HOH A . 
C 2 HOH 142 442 240 HOH HOH A . 
C 2 HOH 143 443 280 HOH HOH A . 
C 2 HOH 144 444 126 HOH HOH A . 
C 2 HOH 145 445 315 HOH HOH A . 
C 2 HOH 146 446 212 HOH HOH A . 
C 2 HOH 147 447 185 HOH HOH A . 
C 2 HOH 148 448 218 HOH HOH A . 
C 2 HOH 149 449 182 HOH HOH A . 
C 2 HOH 150 450 202 HOH HOH A . 
C 2 HOH 151 451 307 HOH HOH A . 
C 2 HOH 152 452 169 HOH HOH A . 
C 2 HOH 153 453 131 HOH HOH A . 
C 2 HOH 154 454 300 HOH HOH A . 
C 2 HOH 155 455 291 HOH HOH A . 
C 2 HOH 156 456 168 HOH HOH A . 
C 2 HOH 157 457 316 HOH HOH A . 
C 2 HOH 158 458 273 HOH HOH A . 
C 2 HOH 159 459 172 HOH HOH A . 
C 2 HOH 160 460 183 HOH HOH A . 
C 2 HOH 161 461 112 HOH HOH A . 
C 2 HOH 162 462 308 HOH HOH A . 
C 2 HOH 163 463 211 HOH HOH A . 
D 2 HOH 1   301 197 HOH HOH B . 
D 2 HOH 2   302 85  HOH HOH B . 
D 2 HOH 3   303 334 HOH HOH B . 
D 2 HOH 4   304 129 HOH HOH B . 
D 2 HOH 5   305 322 HOH HOH B . 
D 2 HOH 6   306 88  HOH HOH B . 
D 2 HOH 7   307 317 HOH HOH B . 
D 2 HOH 8   308 140 HOH HOH B . 
D 2 HOH 9   309 259 HOH HOH B . 
D 2 HOH 10  310 81  HOH HOH B . 
D 2 HOH 11  311 155 HOH HOH B . 
D 2 HOH 12  312 243 HOH HOH B . 
D 2 HOH 13  313 102 HOH HOH B . 
D 2 HOH 14  314 245 HOH HOH B . 
D 2 HOH 15  315 309 HOH HOH B . 
D 2 HOH 16  316 176 HOH HOH B . 
D 2 HOH 17  317 107 HOH HOH B . 
D 2 HOH 18  318 113 HOH HOH B . 
D 2 HOH 19  319 165 HOH HOH B . 
D 2 HOH 20  320 249 HOH HOH B . 
D 2 HOH 21  321 122 HOH HOH B . 
D 2 HOH 22  322 50  HOH HOH B . 
D 2 HOH 23  323 67  HOH HOH B . 
D 2 HOH 24  324 333 HOH HOH B . 
D 2 HOH 25  325 164 HOH HOH B . 
D 2 HOH 26  326 39  HOH HOH B . 
D 2 HOH 27  327 51  HOH HOH B . 
D 2 HOH 28  328 17  HOH HOH B . 
D 2 HOH 29  329 294 HOH HOH B . 
D 2 HOH 30  330 260 HOH HOH B . 
D 2 HOH 31  331 175 HOH HOH B . 
D 2 HOH 32  332 152 HOH HOH B . 
D 2 HOH 33  333 156 HOH HOH B . 
D 2 HOH 34  334 147 HOH HOH B . 
D 2 HOH 35  335 32  HOH HOH B . 
D 2 HOH 36  336 104 HOH HOH B . 
D 2 HOH 37  337 3   HOH HOH B . 
D 2 HOH 38  338 73  HOH HOH B . 
D 2 HOH 39  339 186 HOH HOH B . 
D 2 HOH 40  340 311 HOH HOH B . 
D 2 HOH 41  341 137 HOH HOH B . 
D 2 HOH 42  342 239 HOH HOH B . 
D 2 HOH 43  343 118 HOH HOH B . 
D 2 HOH 44  344 220 HOH HOH B . 
D 2 HOH 45  345 9   HOH HOH B . 
D 2 HOH 46  346 163 HOH HOH B . 
D 2 HOH 47  347 64  HOH HOH B . 
D 2 HOH 48  348 130 HOH HOH B . 
D 2 HOH 49  349 2   HOH HOH B . 
D 2 HOH 50  350 290 HOH HOH B . 
D 2 HOH 51  351 120 HOH HOH B . 
D 2 HOH 52  352 153 HOH HOH B . 
D 2 HOH 53  353 235 HOH HOH B . 
D 2 HOH 54  354 279 HOH HOH B . 
D 2 HOH 55  355 301 HOH HOH B . 
D 2 HOH 56  356 106 HOH HOH B . 
D 2 HOH 57  357 262 HOH HOH B . 
D 2 HOH 58  358 206 HOH HOH B . 
D 2 HOH 59  359 5   HOH HOH B . 
D 2 HOH 60  360 78  HOH HOH B . 
D 2 HOH 61  361 4   HOH HOH B . 
D 2 HOH 62  362 56  HOH HOH B . 
D 2 HOH 63  363 41  HOH HOH B . 
D 2 HOH 64  364 139 HOH HOH B . 
D 2 HOH 65  365 166 HOH HOH B . 
D 2 HOH 66  366 246 HOH HOH B . 
D 2 HOH 67  367 110 HOH HOH B . 
D 2 HOH 68  368 250 HOH HOH B . 
D 2 HOH 69  369 58  HOH HOH B . 
D 2 HOH 70  370 160 HOH HOH B . 
D 2 HOH 71  371 103 HOH HOH B . 
D 2 HOH 72  372 61  HOH HOH B . 
D 2 HOH 73  373 19  HOH HOH B . 
D 2 HOH 74  374 298 HOH HOH B . 
D 2 HOH 75  375 40  HOH HOH B . 
D 2 HOH 76  376 216 HOH HOH B . 
D 2 HOH 77  377 60  HOH HOH B . 
D 2 HOH 78  378 13  HOH HOH B . 
D 2 HOH 79  379 25  HOH HOH B . 
D 2 HOH 80  380 193 HOH HOH B . 
D 2 HOH 81  381 134 HOH HOH B . 
D 2 HOH 82  382 230 HOH HOH B . 
D 2 HOH 83  383 115 HOH HOH B . 
D 2 HOH 84  384 233 HOH HOH B . 
D 2 HOH 85  385 181 HOH HOH B . 
D 2 HOH 86  386 306 HOH HOH B . 
D 2 HOH 87  387 330 HOH HOH B . 
D 2 HOH 88  388 219 HOH HOH B . 
D 2 HOH 89  389 203 HOH HOH B . 
D 2 HOH 90  390 314 HOH HOH B . 
D 2 HOH 91  391 144 HOH HOH B . 
D 2 HOH 92  392 217 HOH HOH B . 
D 2 HOH 93  393 38  HOH HOH B . 
D 2 HOH 94  394 72  HOH HOH B . 
D 2 HOH 95  395 26  HOH HOH B . 
D 2 HOH 96  396 158 HOH HOH B . 
D 2 HOH 97  397 28  HOH HOH B . 
D 2 HOH 98  398 86  HOH HOH B . 
D 2 HOH 99  399 43  HOH HOH B . 
D 2 HOH 100 400 12  HOH HOH B . 
D 2 HOH 101 401 276 HOH HOH B . 
D 2 HOH 102 402 268 HOH HOH B . 
D 2 HOH 103 403 295 HOH HOH B . 
D 2 HOH 104 404 109 HOH HOH B . 
D 2 HOH 105 405 48  HOH HOH B . 
D 2 HOH 106 406 312 HOH HOH B . 
D 2 HOH 107 407 151 HOH HOH B . 
D 2 HOH 108 408 224 HOH HOH B . 
D 2 HOH 109 409 83  HOH HOH B . 
D 2 HOH 110 410 263 HOH HOH B . 
D 2 HOH 111 411 289 HOH HOH B . 
D 2 HOH 112 412 141 HOH HOH B . 
D 2 HOH 113 413 157 HOH HOH B . 
D 2 HOH 114 414 302 HOH HOH B . 
D 2 HOH 115 415 80  HOH HOH B . 
D 2 HOH 116 416 124 HOH HOH B . 
D 2 HOH 117 417 146 HOH HOH B . 
D 2 HOH 118 418 97  HOH HOH B . 
D 2 HOH 119 419 1   HOH HOH B . 
D 2 HOH 120 420 195 HOH HOH B . 
D 2 HOH 121 421 75  HOH HOH B . 
D 2 HOH 122 422 225 HOH HOH B . 
D 2 HOH 123 423 76  HOH HOH B . 
D 2 HOH 124 424 16  HOH HOH B . 
D 2 HOH 125 425 98  HOH HOH B . 
D 2 HOH 126 426 236 HOH HOH B . 
D 2 HOH 127 427 14  HOH HOH B . 
D 2 HOH 128 428 244 HOH HOH B . 
D 2 HOH 129 429 62  HOH HOH B . 
D 2 HOH 130 430 22  HOH HOH B . 
D 2 HOH 131 431 231 HOH HOH B . 
D 2 HOH 132 432 285 HOH HOH B . 
D 2 HOH 133 433 33  HOH HOH B . 
D 2 HOH 134 434 278 HOH HOH B . 
D 2 HOH 135 435 92  HOH HOH B . 
D 2 HOH 136 436 247 HOH HOH B . 
D 2 HOH 137 437 208 HOH HOH B . 
D 2 HOH 138 438 323 HOH HOH B . 
D 2 HOH 139 439 227 HOH HOH B . 
D 2 HOH 140 440 320 HOH HOH B . 
D 2 HOH 141 441 228 HOH HOH B . 
D 2 HOH 142 442 135 HOH HOH B . 
D 2 HOH 143 443 190 HOH HOH B . 
D 2 HOH 144 444 150 HOH HOH B . 
D 2 HOH 145 445 91  HOH HOH B . 
D 2 HOH 146 446 136 HOH HOH B . 
D 2 HOH 147 447 288 HOH HOH B . 
D 2 HOH 148 448 303 HOH HOH B . 
D 2 HOH 149 449 299 HOH HOH B . 
D 2 HOH 150 450 191 HOH HOH B . 
D 2 HOH 151 451 205 HOH HOH B . 
D 2 HOH 152 452 293 HOH HOH B . 
D 2 HOH 153 453 237 HOH HOH B . 
D 2 HOH 154 454 254 HOH HOH B . 
D 2 HOH 155 455 96  HOH HOH B . 
D 2 HOH 156 456 132 HOH HOH B . 
D 2 HOH 157 457 170 HOH HOH B . 
D 2 HOH 158 458 171 HOH HOH B . 
D 2 HOH 159 459 297 HOH HOH B . 
D 2 HOH 160 460 329 HOH HOH B . 
D 2 HOH 161 461 161 HOH HOH B . 
D 2 HOH 162 462 173 HOH HOH B . 
D 2 HOH 163 463 234 HOH HOH B . 
D 2 HOH 164 464 313 HOH HOH B . 
D 2 HOH 165 465 162 HOH HOH B . 
D 2 HOH 166 466 328 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 50  ? CG  ? A LYS 82  CG  
2  1 Y 1 A LYS 50  ? CD  ? A LYS 82  CD  
3  1 Y 1 A LYS 50  ? CE  ? A LYS 82  CE  
4  1 Y 1 A LYS 50  ? NZ  ? A LYS 82  NZ  
5  1 Y 1 A LYS 121 ? CD  ? A LYS 154 CD  
6  1 Y 1 A LYS 121 ? CE  ? A LYS 154 CE  
7  1 Y 1 A LYS 121 ? NZ  ? A LYS 154 NZ  
8  1 Y 1 A LYS 139 ? CE  ? A LYS 172 CE  
9  1 Y 1 A LYS 139 ? NZ  ? A LYS 172 NZ  
10 1 Y 1 A LYS 178 ? CD  ? A LYS 211 CD  
11 1 Y 1 A LYS 178 ? CE  ? A LYS 211 CE  
12 1 Y 1 A LYS 178 ? NZ  ? A LYS 211 NZ  
13 1 Y 1 A ARG 216 ? CZ  ? A ARG 249 CZ  
14 1 Y 1 A ARG 216 ? NH1 ? A ARG 249 NH1 
15 1 Y 1 A ARG 216 ? NH2 ? A ARG 249 NH2 
16 1 Y 1 B LYS 50  ? CG  ? B LYS 82  CG  
17 1 Y 1 B LYS 50  ? CD  ? B LYS 82  CD  
18 1 Y 1 B LYS 50  ? CE  ? B LYS 82  CE  
19 1 Y 1 B LYS 50  ? NZ  ? B LYS 82  NZ  
20 1 Y 1 B LYS 121 ? CD  ? B LYS 154 CD  
21 1 Y 1 B LYS 121 ? CE  ? B LYS 154 CE  
22 1 Y 1 B LYS 121 ? NZ  ? B LYS 154 NZ  
23 1 Y 1 B LYS 139 ? CE  ? B LYS 172 CE  
24 1 Y 1 B LYS 139 ? NZ  ? B LYS 172 NZ  
25 1 Y 1 B LYS 162 ? CG  ? B LYS 195 CG  
26 1 Y 1 B LYS 162 ? CD  ? B LYS 195 CD  
27 1 Y 1 B LYS 162 ? CE  ? B LYS 195 CE  
28 1 Y 1 B LYS 162 ? NZ  ? B LYS 195 NZ  
29 1 Y 1 B LYS 178 ? CD  ? B LYS 211 CD  
30 1 Y 1 B LYS 178 ? CE  ? B LYS 211 CE  
31 1 Y 1 B LYS 178 ? NZ  ? B LYS 211 NZ  
32 1 Y 1 B ARG 216 ? CZ  ? B ARG 249 CZ  
33 1 Y 1 B ARG 216 ? NH1 ? B ARG 249 NH1 
34 1 Y 1 B ARG 216 ? NH2 ? B ARG 249 NH2 
35 1 Y 1 B THR 223 ? CB  ? B THR 256 CB  
36 1 Y 1 B THR 223 ? OG1 ? B THR 256 OG1 
37 1 Y 1 B THR 223 ? CG2 ? B THR 256 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0267 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FER 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     61.320 
_cell.length_a_esd                 ? 
_cell.length_b                     77.750 
_cell.length_b_esd                 ? 
_cell.length_c                     96.700 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FER 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FER 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.95 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.04 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;200mM Sodium chloride
100mM TRIS 
30% w/v Polyethylene glycol 3350
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      'Rigaku Osmic VariMax' 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 300K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU MICROMAX-007 HF' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9FER 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.65 
_reflns.d_resolution_low                               50.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     105191 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.02 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.11199999999999999 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.09699999999999999 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
1.65 1.69 ? ? ? ? ? ? 7560 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1.224                ? ? 1  1 0.535              ? ? ? ? 1.014 ? ? ? ? ? 
? ? ? ? 
1.69 1.74 ? ? ? ? ? ? 7446 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1.038                ? ? 2  1 0.634              ? ? ? ? 0.865 ? ? ? ? ? 
? ? ? ? 
1.74 1.79 ? ? ? ? ? ? 7320 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.8220000000000001   ? ? 3  1 0.75               ? ? ? ? 0.688 ? ? ? ? ? 
? ? ? ? 
1.79 1.84 ? ? ? ? ? ? 7194 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.713                ? ? 4  1 0.794              ? ? ? ? 0.6 ? ? ? ? ? ? 
? ? ? 
1.84 1.91 ? ? ? ? ? ? 6932 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.813                ? ? 5  1 0.8440000000000001 ? ? ? ? 
0.6829999999999999   ? ? ? ? ? ? ? ? ? 
1.91 1.97 ? ? ? ? ? ? 6656 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.479                ? ? 6  1 0.884              ? ? ? ? 0.401 ? ? ? ? ? 
? ? ? ? 
1.97 2.05 ? ? ? ? ? ? 6519 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.371                ? ? 7  1 0.922              ? ? ? ? 0.311 ? ? ? ? ? 
? ? ? ? 
2.05 2.13 ? ? ? ? ? ? 6346 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.292                ? ? 8  1 0.9570000000000001 ? ? ? ? 
0.24600000000000002  ? ? ? ? ? ? ? ? ? 
2.13 2.22 ? ? ? ? ? ? 5966 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.285                ? ? 9  1 0.963              ? ? ? ? 0.239 ? ? ? ? ? 
? ? ? ? 
2.22 2.33 ? ? ? ? ? ? 5521 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.299                ? ? 10 1 0.9279999999999999 ? ? ? ? 0.242 ? ? ? ? ? 
? ? ? ? 
2.33 2.46 ? ? ? ? ? ? 5512 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.18100000000000002  ? ? 11 1 0.978              ? ? ? ? 0.15 ? ? ? ? ? ? 
? ? ? 
2.46 2.61 ? ? ? ? ? ? 5243 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.16699999999999998  ? ? 12 1 0.9890000000000001 ? ? ? ? 0.145 ? ? ? ? ? 
? ? ? ? 
2.61 2.79 ? ? ? ? ? ? 4927 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.129                ? ? 13 1 0.993              ? ? ? ? 0.114 ? ? ? ? ? 
? ? ? ? 
2.79 3.01 ? ? ? ? ? ? 4584 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.094                ? ? 14 1 0.996              ? ? ? ? 0.083 ? ? ? ? ? 
? ? ? ? 
3.01 3.3  ? ? ? ? ? ? 4177 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.069                ? ? 15 1 0.998              ? ? ? ? 0.061 ? ? ? ? ? 
? ? ? ? 
3.30 3.69 ? ? ? ? ? ? 3752 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.055999999999999994 ? ? 16 1 0.9990000000000001 ? ? ? ? 0.051 ? ? ? ? ? 
? ? ? ? 
3.69 4.26 ? ? ? ? ? ? 3318 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.049                ? ? 17 1 0.9990000000000001 ? ? ? ? 0.045 ? ? ? ? ? 
? ? ? ? 
4.26 5.22 ? ? ? ? ? ? 2848 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.04                 ? ? 18 1 0.9990000000000001 ? ? ? ? 0.038 ? ? ? ? ? 
? ? ? ? 
5.22 7.38 ? ? ? ? ? ? 2185 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.047                ? ? 19 1 0.9990000000000001 ? ? ? ? 
0.044000000000000004 ? ? ? ? ? ? ? ? ? 
7.38 50.0 ? ? ? ? ? ? 1185 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.035                ? ? 20 1 0.9990000000000001 ? ? ? ? 0.032 ? ? ? ? ? 
? ? ? ? 
# 
_refine.aniso_B[1][1]                            -0.57 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            0.70 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -0.13 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               18.115 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.951 
_refine.correlation_coeff_Fo_to_Fc_free          0.931 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FER 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.65 
_refine.ls_d_res_low                             43.14 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     52922 
_refine.ls_number_reflns_R_free                  2794 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.91 
_refine.ls_percent_reflns_R_free                 5.0 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.21138 
_refine.ls_R_factor_R_free                       0.25260 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20920 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'BABINET MODEL WITH MASK' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.112 
_refine.pdbx_overall_ESU_R_Free                  0.114 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             2.751 
_refine.overall_SU_ML                            0.089 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.65 
_refine_hist.d_res_low                        43.14 
_refine_hist.number_atoms_solvent             329 
_refine_hist.number_atoms_total               3796 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3467 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.015  0.013  3572 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  3254 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 2.031  1.676  4813 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 1.496  1.600  7554 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 8.065  5.000  435  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 31.693 23.155 187  ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 14.053 15.000 613  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.178 15.000 18   ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.092  0.200  436  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.012  0.020  4032 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  790  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.092  1.749  1734 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.023  1.746  1733 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 2.945  2.614  2162 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.959  2.618  2163 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 2.894  1.979  1838 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.823  1.980  1838 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.296  2.855  2648 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.348  20.186 3869 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 5.308  19.950 3804 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.650 
_refine_ls_shell.d_res_low                        1.693 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             189 
_refine_ls_shell.number_reflns_R_work             3775 
_refine_ls_shell.percent_reflns_obs               96.64 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.299 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.314 
# 
_struct.entry_id                     9FER 
_struct.title                        'wasCFP (SG P21) - Directionality of Optical Properties of Fluorescent Proteins' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FER 
_struct_keywords.text            'FLUORESCENT PROTEIN' 
_struct_keywords.pdbx_keywords   'FLUORESCENT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q5S3G7_9CNID 
_struct_ref.pdbx_db_accession          Q5S3G7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MVSKGEEVIKEFMRFKEHMEGSVNGHEFEIEGEGEGRPYEGTQTARLKVTKGGPLPFAWDILSPQIMYGSKAYVKHPADI
PDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKVRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKG
EMKMRLRLKDGGHYDAEVKTTYMAKKPVQLPGAYKTDIKLDITSHNEDYTIVEQYERAEGRHSTGA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9FER A 32 ? 258 ? Q5S3G7 1 ? 226 ? 0 225 
2 1 9FER B 32 ? 258 ? Q5S3G7 1 ? 226 ? 0 225 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FER HIS A 1   ? UNP Q5S3G7 ? ? 'expression tag' -31 1  
1 9FER HIS A 2   ? UNP Q5S3G7 ? ? 'expression tag' -30 2  
1 9FER HIS A 3   ? UNP Q5S3G7 ? ? 'expression tag' -29 3  
1 9FER HIS A 4   ? UNP Q5S3G7 ? ? 'expression tag' -28 4  
1 9FER HIS A 5   ? UNP Q5S3G7 ? ? 'expression tag' -27 5  
1 9FER HIS A 6   ? UNP Q5S3G7 ? ? 'expression tag' -26 6  
1 9FER GLY A 7   ? UNP Q5S3G7 ? ? 'expression tag' -25 7  
1 9FER MET A 8   ? UNP Q5S3G7 ? ? 'expression tag' -24 8  
1 9FER ALA A 9   ? UNP Q5S3G7 ? ? 'expression tag' -23 9  
1 9FER SER A 10  ? UNP Q5S3G7 ? ? 'expression tag' -22 10 
1 9FER MET A 11  ? UNP Q5S3G7 ? ? 'expression tag' -21 11 
1 9FER THR A 12  ? UNP Q5S3G7 ? ? 'expression tag' -20 12 
1 9FER GLY A 13  ? UNP Q5S3G7 ? ? 'expression tag' -19 13 
1 9FER GLY A 14  ? UNP Q5S3G7 ? ? 'expression tag' -18 14 
1 9FER GLN A 15  ? UNP Q5S3G7 ? ? 'expression tag' -17 15 
1 9FER GLN A 16  ? UNP Q5S3G7 ? ? 'expression tag' -16 16 
1 9FER MET A 17  ? UNP Q5S3G7 ? ? 'expression tag' -15 17 
1 9FER GLY A 18  ? UNP Q5S3G7 ? ? 'expression tag' -14 18 
1 9FER ARG A 19  ? UNP Q5S3G7 ? ? 'expression tag' -13 19 
1 9FER ASP A 20  ? UNP Q5S3G7 ? ? 'expression tag' -12 20 
1 9FER LEU A 21  ? UNP Q5S3G7 ? ? 'expression tag' -11 21 
1 9FER TYR A 22  ? UNP Q5S3G7 ? ? 'expression tag' -10 22 
1 9FER GLU A 23  ? UNP Q5S3G7 ? ? 'expression tag' -9  23 
1 9FER ASN A 24  ? UNP Q5S3G7 ? ? 'expression tag' -8  24 
1 9FER LEU A 25  ? UNP Q5S3G7 ? ? 'expression tag' -7  25 
1 9FER TYR A 26  ? UNP Q5S3G7 ? ? 'expression tag' -6  26 
1 9FER PHE A 27  ? UNP Q5S3G7 ? ? 'expression tag' -5  27 
1 9FER GLN A 28  ? UNP Q5S3G7 ? ? 'expression tag' -4  28 
1 9FER GLY A 29  ? UNP Q5S3G7 ? ? 'expression tag' -3  29 
1 9FER SER A 30  ? UNP Q5S3G7 ? ? 'expression tag' -2  30 
1 9FER SER A 31  ? UNP Q5S3G7 ? ? 'expression tag' -1  31 
1 9FER CH6 A 101 ? UNP Q5S3G7 ? ? insertion        68  32 
2 9FER HIS B 1   ? UNP Q5S3G7 ? ? 'expression tag' -31 33 
2 9FER HIS B 2   ? UNP Q5S3G7 ? ? 'expression tag' -30 34 
2 9FER HIS B 3   ? UNP Q5S3G7 ? ? 'expression tag' -29 35 
2 9FER HIS B 4   ? UNP Q5S3G7 ? ? 'expression tag' -28 36 
2 9FER HIS B 5   ? UNP Q5S3G7 ? ? 'expression tag' -27 37 
2 9FER HIS B 6   ? UNP Q5S3G7 ? ? 'expression tag' -26 38 
2 9FER GLY B 7   ? UNP Q5S3G7 ? ? 'expression tag' -25 39 
2 9FER MET B 8   ? UNP Q5S3G7 ? ? 'expression tag' -24 40 
2 9FER ALA B 9   ? UNP Q5S3G7 ? ? 'expression tag' -23 41 
2 9FER SER B 10  ? UNP Q5S3G7 ? ? 'expression tag' -22 42 
2 9FER MET B 11  ? UNP Q5S3G7 ? ? 'expression tag' -21 43 
2 9FER THR B 12  ? UNP Q5S3G7 ? ? 'expression tag' -20 44 
2 9FER GLY B 13  ? UNP Q5S3G7 ? ? 'expression tag' -19 45 
2 9FER GLY B 14  ? UNP Q5S3G7 ? ? 'expression tag' -18 46 
2 9FER GLN B 15  ? UNP Q5S3G7 ? ? 'expression tag' -17 47 
2 9FER GLN B 16  ? UNP Q5S3G7 ? ? 'expression tag' -16 48 
2 9FER MET B 17  ? UNP Q5S3G7 ? ? 'expression tag' -15 49 
2 9FER GLY B 18  ? UNP Q5S3G7 ? ? 'expression tag' -14 50 
2 9FER ARG B 19  ? UNP Q5S3G7 ? ? 'expression tag' -13 51 
2 9FER ASP B 20  ? UNP Q5S3G7 ? ? 'expression tag' -12 52 
2 9FER LEU B 21  ? UNP Q5S3G7 ? ? 'expression tag' -11 53 
2 9FER TYR B 22  ? UNP Q5S3G7 ? ? 'expression tag' -10 54 
2 9FER GLU B 23  ? UNP Q5S3G7 ? ? 'expression tag' -9  55 
2 9FER ASN B 24  ? UNP Q5S3G7 ? ? 'expression tag' -8  56 
2 9FER LEU B 25  ? UNP Q5S3G7 ? ? 'expression tag' -7  57 
2 9FER TYR B 26  ? UNP Q5S3G7 ? ? 'expression tag' -6  58 
2 9FER PHE B 27  ? UNP Q5S3G7 ? ? 'expression tag' -5  59 
2 9FER GLN B 28  ? UNP Q5S3G7 ? ? 'expression tag' -4  60 
2 9FER GLY B 29  ? UNP Q5S3G7 ? ? 'expression tag' -3  61 
2 9FER SER B 30  ? UNP Q5S3G7 ? ? 'expression tag' -2  62 
2 9FER SER B 31  ? UNP Q5S3G7 ? ? 'expression tag' -1  63 
2 9FER CH6 B 101 ? UNP Q5S3G7 ? ? insertion        68  64 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C 
2 1 B,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 89  ? LEU A 93  ? ALA A 57 LEU A 61 5 ? 5 
HELX_P HELX_P2 AA2 ASP A 114 ? SER A 119 ? ASP A 81 SER A 86 1 ? 6 
HELX_P HELX_P3 AA3 ALA B 89  ? LEU B 93  ? ALA B 57 LEU B 61 5 ? 5 
HELX_P HELX_P4 AA4 ASP B 114 ? SER B 119 ? ASP B 81 SER B 86 1 ? 6 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A ILE 97  C  ? ? ? 1_555 A CH6 101 N1 ? ? A ILE 65 A CH6 68 1_555 ? ? ? ? ? ? ? 1.288 ? ? 
covale2 covale both ? A CH6 101 C3 ? ? ? 1_555 A SER 102 N  ? ? A CH6 68 A SER 69 1_555 ? ? ? ? ? ? ? 1.474 ? ? 
covale3 covale both ? B ILE 97  C  ? ? ? 1_555 B CH6 101 N1 ? ? B ILE 65 B CH6 68 1_555 ? ? ? ? ? ? ? 1.306 ? ? 
covale4 covale both ? B CH6 101 C3 ? ? ? 1_555 B SER 102 N  ? ? B CH6 68 B SER 69 1_555 ? ? ? ? ? ? ? 1.533 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CH6 A 101 ? . . . . CH6 A 68 ? 1_555 . . . . . . . 'MET, TYR, GLY' 1 CH6 None Chromophore/chromophore-like 
2 CH6 B 101 ? . . . . CH6 B 68 ? 1_555 . . . . . . . 'MET, TYR, GLY' 1 CH6 None Chromophore/chromophore-like 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 84  A . ? GLY 52  A PRO 85  A ? PRO 53  A 1 0.23   
2 PHE 120 A . ? PHE 87  A PRO 121 A ? PRO 88  A 1 9.98   
3 GLY 84  B . ? GLY 52  B PRO 85  B ? PRO 53  B 1 4.01   
4 PHE 120 B . ? PHE 87  B PRO 121 B ? PRO 88  B 1 6.10   
5 THR 256 B . ? THR 223 B GLY 257 B ? GLY 224 B 1 -21.99 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 13 ? 
AA2 ? 13 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 2  3  ? anti-parallel 
AA1 3  4  ? anti-parallel 
AA1 4  5  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? parallel      
AA1 7  8  ? anti-parallel 
AA1 8  9  ? anti-parallel 
AA1 9  10 ? anti-parallel 
AA1 10 11 ? anti-parallel 
AA1 11 12 ? anti-parallel 
AA1 12 13 ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 2  3  ? anti-parallel 
AA2 3  4  ? anti-parallel 
AA2 4  5  ? anti-parallel 
AA2 5  6  ? anti-parallel 
AA2 6  7  ? parallel      
AA2 7  8  ? anti-parallel 
AA2 8  9  ? anti-parallel 
AA2 9  10 ? anti-parallel 
AA2 10 11 ? anti-parallel 
AA2 11 12 ? anti-parallel 
AA2 12 13 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  THR A 173 ? TRP A 176 ? THR A 140 TRP A 143 
AA1 2  ALA A 189 ? LEU A 200 ? ALA A 156 LEU A 167 
AA1 3  HIS A 205 ? ALA A 216 ? HIS A 172 ALA A 183 
AA1 4  PHE A 124 ? PHE A 132 ? PHE A 91  PHE A 99  
AA1 5  VAL A 137 ? GLN A 147 ? VAL A 104 GLN A 114 
AA1 6  GLU A 150 ? THR A 160 ? GLU A 117 THR A 127 
AA1 7  MET A 44  ? VAL A 54  ? MET A 12  VAL A 22  
AA1 8  HIS A 57  ? ARG A 68  ? HIS A 25  ARG A 36  
AA1 9  THR A 73  ? LYS A 82  ? THR A 41  LYS A 50  
AA1 10 ILE A 243 ? ARG A 253 ? ILE A 210 ARG A 220 
AA1 11 TYR A 226 ? HIS A 237 ? TYR A 193 HIS A 204 
AA1 12 SER A 179 ? GLU A 186 ? SER A 146 GLU A 153 
AA1 13 ALA A 189 ? LEU A 200 ? ALA A 156 LEU A 167 
AA2 1  THR B 173 ? TRP B 176 ? THR B 140 TRP B 143 
AA2 2  ALA B 189 ? LEU B 200 ? ALA B 156 LEU B 167 
AA2 3  HIS B 205 ? ALA B 216 ? HIS B 172 ALA B 183 
AA2 4  PHE B 124 ? PHE B 132 ? PHE B 91  PHE B 99  
AA2 5  VAL B 137 ? GLN B 147 ? VAL B 104 GLN B 114 
AA2 6  GLU B 150 ? THR B 160 ? GLU B 117 THR B 127 
AA2 7  MET B 44  ? VAL B 54  ? MET B 12  VAL B 22  
AA2 8  HIS B 57  ? ARG B 68  ? HIS B 25  ARG B 36  
AA2 9  THR B 73  ? LYS B 82  ? THR B 41  LYS B 50  
AA2 10 ILE B 243 ? ARG B 253 ? ILE B 210 ARG B 220 
AA2 11 TYR B 226 ? HIS B 237 ? TYR B 193 HIS B 204 
AA2 12 SER B 179 ? GLU B 186 ? SER B 146 GLU B 153 
AA2 13 ALA B 189 ? LEU B 200 ? ALA B 156 LEU B 167 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N MET A 174 ? N MET A 141 O ARG A 199 ? O ARG A 166 
AA1 2  3  N MET A 196 ? N MET A 163 O ALA A 208 ? O ALA A 175 
AA1 3  4  O MET A 215 ? O MET A 182 N LYS A 125 ? N LYS A 92  
AA1 4  5  N PHE A 124 ? N PHE A 91  O SER A 144 ? O SER A 111 
AA1 5  6  N SER A 145 ? N SER A 112 O ILE A 152 ? O ILE A 119 
AA1 6  7  O VAL A 155 ? O VAL A 122 N HIS A 49  ? N HIS A 17  
AA1 7  8  N MET A 50  ? N MET A 18  O ILE A 61  ? O ILE A 29  
AA1 8  9  N GLU A 64  ? N GLU A 32  O ARG A 77  ? O ARG A 45  
AA1 9  10 N LEU A 78  ? N LEU A 46  O VAL A 244 ? O VAL A 211 
AA1 10 11 O TYR A 247 ? O TYR A 214 N ASP A 233 ? N ASP A 200 
AA1 11 12 O THR A 228 ? O THR A 195 N GLU A 181 ? N GLU A 148 
AA1 12 13 N ARG A 182 ? N ARG A 149 O GLU A 193 ? O GLU A 160 
AA2 1  2  N GLY B 175 ? N GLY B 142 O ARG B 199 ? O ARG B 166 
AA2 2  3  N LEU B 190 ? N LEU B 157 O TYR B 214 ? O TYR B 181 
AA2 3  4  O MET B 215 ? O MET B 182 N LYS B 125 ? N LYS B 92  
AA2 4  5  N MET B 130 ? N MET B 97  O VAL B 138 ? O VAL B 105 
AA2 5  6  N SER B 145 ? N SER B 112 O ILE B 152 ? O ILE B 119 
AA2 6  7  O VAL B 155 ? O VAL B 122 N HIS B 49  ? N HIS B 17  
AA2 7  8  N GLU B 48  ? N GLU B 16  O GLY B 63  ? O GLY B 31  
AA2 8  9  N GLU B 66  ? N GLU B 34  O THR B 75  ? O THR B 43  
AA2 9  10 N LEU B 78  ? N LEU B 46  O VAL B 244 ? O VAL B 211 
AA2 10 11 O TYR B 247 ? O TYR B 214 N ASP B 233 ? N ASP B 200 
AA2 11 12 O ILE B 230 ? O ILE B 197 N SER B 179 ? N SER B 146 
AA2 12 13 N TYR B 184 ? N TYR B 151 O LYS B 191 ? O LYS B 158 
# 
_pdbx_entry_details.entry_id                   9FER 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CD A GLU 30 ? ? OE2 A GLU 30 ? ? 1.179 1.252 -0.073 0.011 N 
2 1 CD A GLU 94 ? ? OE1 A GLU 94 ? ? 1.363 1.252 0.111  0.011 N 
3 1 CD B GLU 94 ? ? OE1 B GLU 94 ? ? 1.338 1.252 0.086  0.011 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 72  ? ? -103.96 67.49   
2 1 MET A 141 ? ? -150.00 46.16   
3 1 ASP A 169 ? ? 154.00  -44.82  
4 1 TYR B 72  ? ? -108.59 65.78   
5 1 MET B 141 ? ? -141.44 40.91   
6 1 LYS B 168 ? ? -67.81  78.76   
7 1 ASP B 169 ? ? 162.69  -29.69  
8 1 THR B 223 ? ? 30.37   -116.51 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   GLY 
_pdbx_validate_peptide_omega.auth_asym_id_1   B 
_pdbx_validate_peptide_omega.auth_seq_id_1    224 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   ALA 
_pdbx_validate_peptide_omega.auth_asym_id_2   B 
_pdbx_validate_peptide_omega.auth_seq_id_2    225 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            149.61 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A HIS -31 ? A HIS 1   
2  1 Y 1 A HIS -30 ? A HIS 2   
3  1 Y 1 A HIS -29 ? A HIS 3   
4  1 Y 1 A HIS -28 ? A HIS 4   
5  1 Y 1 A HIS -27 ? A HIS 5   
6  1 Y 1 A HIS -26 ? A HIS 6   
7  1 Y 1 A GLY -25 ? A GLY 7   
8  1 Y 1 A MET -24 ? A MET 8   
9  1 Y 1 A ALA -23 ? A ALA 9   
10 1 Y 1 A SER -22 ? A SER 10  
11 1 Y 1 A MET -21 ? A MET 11  
12 1 Y 1 A THR -20 ? A THR 12  
13 1 Y 1 A GLY -19 ? A GLY 13  
14 1 Y 1 A GLY -18 ? A GLY 14  
15 1 Y 1 A GLN -17 ? A GLN 15  
16 1 Y 1 A GLN -16 ? A GLN 16  
17 1 Y 1 A MET -15 ? A MET 17  
18 1 Y 1 A GLY -14 ? A GLY 18  
19 1 Y 1 A ARG -13 ? A ARG 19  
20 1 Y 1 A ASP -12 ? A ASP 20  
21 1 Y 1 A LEU -11 ? A LEU 21  
22 1 Y 1 A TYR -10 ? A TYR 22  
23 1 Y 1 A GLU -9  ? A GLU 23  
24 1 Y 1 A ASN -8  ? A ASN 24  
25 1 Y 1 A LEU -7  ? A LEU 25  
26 1 Y 1 A TYR -6  ? A TYR 26  
27 1 Y 1 A PHE -5  ? A PHE 27  
28 1 Y 1 A GLN -4  ? A GLN 28  
29 1 Y 1 A GLY -3  ? A GLY 29  
30 1 Y 1 A SER -2  ? A SER 30  
31 1 Y 1 A SER -1  ? A SER 31  
32 1 Y 1 A MET 0   ? A MET 32  
33 1 Y 1 A VAL 1   ? A VAL 33  
34 1 Y 1 A SER 2   ? A SER 34  
35 1 Y 1 A LYS 3   ? A LYS 35  
36 1 Y 1 A GLY 4   ? A GLY 36  
37 1 Y 1 A GLU 5   ? A GLU 37  
38 1 Y 1 A MET 65  A A MET 98  
39 1 Y 1 A TYR 65  B A TYR 99  
40 1 Y 1 A GLY 65  C A GLY 100 
41 1 Y 1 A ALA 225 ? A ALA 258 
42 1 Y 1 B HIS -31 ? B HIS 1   
43 1 Y 1 B HIS -30 ? B HIS 2   
44 1 Y 1 B HIS -29 ? B HIS 3   
45 1 Y 1 B HIS -28 ? B HIS 4   
46 1 Y 1 B HIS -27 ? B HIS 5   
47 1 Y 1 B HIS -26 ? B HIS 6   
48 1 Y 1 B GLY -25 ? B GLY 7   
49 1 Y 1 B MET -24 ? B MET 8   
50 1 Y 1 B ALA -23 ? B ALA 9   
51 1 Y 1 B SER -22 ? B SER 10  
52 1 Y 1 B MET -21 ? B MET 11  
53 1 Y 1 B THR -20 ? B THR 12  
54 1 Y 1 B GLY -19 ? B GLY 13  
55 1 Y 1 B GLY -18 ? B GLY 14  
56 1 Y 1 B GLN -17 ? B GLN 15  
57 1 Y 1 B GLN -16 ? B GLN 16  
58 1 Y 1 B MET -15 ? B MET 17  
59 1 Y 1 B GLY -14 ? B GLY 18  
60 1 Y 1 B ARG -13 ? B ARG 19  
61 1 Y 1 B ASP -12 ? B ASP 20  
62 1 Y 1 B LEU -11 ? B LEU 21  
63 1 Y 1 B TYR -10 ? B TYR 22  
64 1 Y 1 B GLU -9  ? B GLU 23  
65 1 Y 1 B ASN -8  ? B ASN 24  
66 1 Y 1 B LEU -7  ? B LEU 25  
67 1 Y 1 B TYR -6  ? B TYR 26  
68 1 Y 1 B PHE -5  ? B PHE 27  
69 1 Y 1 B GLN -4  ? B GLN 28  
70 1 Y 1 B GLY -3  ? B GLY 29  
71 1 Y 1 B SER -2  ? B SER 30  
72 1 Y 1 B SER -1  ? B SER 31  
73 1 Y 1 B MET 0   ? B MET 32  
74 1 Y 1 B VAL 1   ? B VAL 33  
75 1 Y 1 B SER 2   ? B SER 34  
76 1 Y 1 B LYS 3   ? B LYS 35  
77 1 Y 1 B GLY 4   ? B GLY 36  
78 1 Y 1 B GLU 5   ? B GLU 37  
79 1 Y 1 B MET 65  A B MET 98  
80 1 Y 1 B TYR 65  B B TYR 99  
81 1 Y 1 B GLY 65  C B GLY 100 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CH6 N1   N N N 74  
CH6 CE   C N N 75  
CH6 SD   S N N 76  
CH6 CG1  C N N 77  
CH6 CB1  C N N 78  
CH6 CA1  C N S 79  
CH6 C1   C N N 80  
CH6 N2   N N N 81  
CH6 OH   O N N 82  
CH6 CD2  C Y N 83  
CH6 CE2  C Y N 84  
CH6 CZ   C Y N 85  
CH6 CE1  C Y N 86  
CH6 CD1  C Y N 87  
CH6 CG2  C Y N 88  
CH6 CB2  C N N 89  
CH6 CA2  C N N 90  
CH6 C2   C N N 91  
CH6 O2   O N N 92  
CH6 N3   N N N 93  
CH6 CA3  C N N 94  
CH6 C3   C N N 95  
CH6 O3   O N N 96  
CH6 OXT  O N N 97  
CH6 H    H N N 98  
CH6 H2   H N N 99  
CH6 HE1A H N N 100 
CH6 HE2A H N N 101 
CH6 HE3  H N N 102 
CH6 HG11 H N N 103 
CH6 HG12 H N N 104 
CH6 HB11 H N N 105 
CH6 HB12 H N N 106 
CH6 HA1  H N N 107 
CH6 HOH  H N N 108 
CH6 HD2  H N N 109 
CH6 HE2  H N N 110 
CH6 HE1  H N N 111 
CH6 HD1  H N N 112 
CH6 HB2  H N N 113 
CH6 HA31 H N N 114 
CH6 HA32 H N N 115 
CH6 HXT  H N N 116 
GLN N    N N N 117 
GLN CA   C N S 118 
GLN C    C N N 119 
GLN O    O N N 120 
GLN CB   C N N 121 
GLN CG   C N N 122 
GLN CD   C N N 123 
GLN OE1  O N N 124 
GLN NE2  N N N 125 
GLN OXT  O N N 126 
GLN H    H N N 127 
GLN H2   H N N 128 
GLN HA   H N N 129 
GLN HB2  H N N 130 
GLN HB3  H N N 131 
GLN HG2  H N N 132 
GLN HG3  H N N 133 
GLN HE21 H N N 134 
GLN HE22 H N N 135 
GLN HXT  H N N 136 
GLU N    N N N 137 
GLU CA   C N S 138 
GLU C    C N N 139 
GLU O    O N N 140 
GLU CB   C N N 141 
GLU CG   C N N 142 
GLU CD   C N N 143 
GLU OE1  O N N 144 
GLU OE2  O N N 145 
GLU OXT  O N N 146 
GLU H    H N N 147 
GLU H2   H N N 148 
GLU HA   H N N 149 
GLU HB2  H N N 150 
GLU HB3  H N N 151 
GLU HG2  H N N 152 
GLU HG3  H N N 153 
GLU HE2  H N N 154 
GLU HXT  H N N 155 
GLY N    N N N 156 
GLY CA   C N N 157 
GLY C    C N N 158 
GLY O    O N N 159 
GLY OXT  O N N 160 
GLY H    H N N 161 
GLY H2   H N N 162 
GLY HA2  H N N 163 
GLY HA3  H N N 164 
GLY HXT  H N N 165 
HIS N    N N N 166 
HIS CA   C N S 167 
HIS C    C N N 168 
HIS O    O N N 169 
HIS CB   C N N 170 
HIS CG   C Y N 171 
HIS ND1  N Y N 172 
HIS CD2  C Y N 173 
HIS CE1  C Y N 174 
HIS NE2  N Y N 175 
HIS OXT  O N N 176 
HIS H    H N N 177 
HIS H2   H N N 178 
HIS HA   H N N 179 
HIS HB2  H N N 180 
HIS HB3  H N N 181 
HIS HD1  H N N 182 
HIS HD2  H N N 183 
HIS HE1  H N N 184 
HIS HE2  H N N 185 
HIS HXT  H N N 186 
HOH O    O N N 187 
HOH H1   H N N 188 
HOH H2   H N N 189 
ILE N    N N N 190 
ILE CA   C N S 191 
ILE C    C N N 192 
ILE O    O N N 193 
ILE CB   C N S 194 
ILE CG1  C N N 195 
ILE CG2  C N N 196 
ILE CD1  C N N 197 
ILE OXT  O N N 198 
ILE H    H N N 199 
ILE H2   H N N 200 
ILE HA   H N N 201 
ILE HB   H N N 202 
ILE HG12 H N N 203 
ILE HG13 H N N 204 
ILE HG21 H N N 205 
ILE HG22 H N N 206 
ILE HG23 H N N 207 
ILE HD11 H N N 208 
ILE HD12 H N N 209 
ILE HD13 H N N 210 
ILE HXT  H N N 211 
LEU N    N N N 212 
LEU CA   C N S 213 
LEU C    C N N 214 
LEU O    O N N 215 
LEU CB   C N N 216 
LEU CG   C N N 217 
LEU CD1  C N N 218 
LEU CD2  C N N 219 
LEU OXT  O N N 220 
LEU H    H N N 221 
LEU H2   H N N 222 
LEU HA   H N N 223 
LEU HB2  H N N 224 
LEU HB3  H N N 225 
LEU HG   H N N 226 
LEU HD11 H N N 227 
LEU HD12 H N N 228 
LEU HD13 H N N 229 
LEU HD21 H N N 230 
LEU HD22 H N N 231 
LEU HD23 H N N 232 
LEU HXT  H N N 233 
LYS N    N N N 234 
LYS CA   C N S 235 
LYS C    C N N 236 
LYS O    O N N 237 
LYS CB   C N N 238 
LYS CG   C N N 239 
LYS CD   C N N 240 
LYS CE   C N N 241 
LYS NZ   N N N 242 
LYS OXT  O N N 243 
LYS H    H N N 244 
LYS H2   H N N 245 
LYS HA   H N N 246 
LYS HB2  H N N 247 
LYS HB3  H N N 248 
LYS HG2  H N N 249 
LYS HG3  H N N 250 
LYS HD2  H N N 251 
LYS HD3  H N N 252 
LYS HE2  H N N 253 
LYS HE3  H N N 254 
LYS HZ1  H N N 255 
LYS HZ2  H N N 256 
LYS HZ3  H N N 257 
LYS HXT  H N N 258 
MET N    N N N 259 
MET CA   C N S 260 
MET C    C N N 261 
MET O    O N N 262 
MET CB   C N N 263 
MET CG   C N N 264 
MET SD   S N N 265 
MET CE   C N N 266 
MET OXT  O N N 267 
MET H    H N N 268 
MET H2   H N N 269 
MET HA   H N N 270 
MET HB2  H N N 271 
MET HB3  H N N 272 
MET HG2  H N N 273 
MET HG3  H N N 274 
MET HE1  H N N 275 
MET HE2  H N N 276 
MET HE3  H N N 277 
MET HXT  H N N 278 
PHE N    N N N 279 
PHE CA   C N S 280 
PHE C    C N N 281 
PHE O    O N N 282 
PHE CB   C N N 283 
PHE CG   C Y N 284 
PHE CD1  C Y N 285 
PHE CD2  C Y N 286 
PHE CE1  C Y N 287 
PHE CE2  C Y N 288 
PHE CZ   C Y N 289 
PHE OXT  O N N 290 
PHE H    H N N 291 
PHE H2   H N N 292 
PHE HA   H N N 293 
PHE HB2  H N N 294 
PHE HB3  H N N 295 
PHE HD1  H N N 296 
PHE HD2  H N N 297 
PHE HE1  H N N 298 
PHE HE2  H N N 299 
PHE HZ   H N N 300 
PHE HXT  H N N 301 
PRO N    N N N 302 
PRO CA   C N S 303 
PRO C    C N N 304 
PRO O    O N N 305 
PRO CB   C N N 306 
PRO CG   C N N 307 
PRO CD   C N N 308 
PRO OXT  O N N 309 
PRO H    H N N 310 
PRO HA   H N N 311 
PRO HB2  H N N 312 
PRO HB3  H N N 313 
PRO HG2  H N N 314 
PRO HG3  H N N 315 
PRO HD2  H N N 316 
PRO HD3  H N N 317 
PRO HXT  H N N 318 
SER N    N N N 319 
SER CA   C N S 320 
SER C    C N N 321 
SER O    O N N 322 
SER CB   C N N 323 
SER OG   O N N 324 
SER OXT  O N N 325 
SER H    H N N 326 
SER H2   H N N 327 
SER HA   H N N 328 
SER HB2  H N N 329 
SER HB3  H N N 330 
SER HG   H N N 331 
SER HXT  H N N 332 
THR N    N N N 333 
THR CA   C N S 334 
THR C    C N N 335 
THR O    O N N 336 
THR CB   C N R 337 
THR OG1  O N N 338 
THR CG2  C N N 339 
THR OXT  O N N 340 
THR H    H N N 341 
THR H2   H N N 342 
THR HA   H N N 343 
THR HB   H N N 344 
THR HG1  H N N 345 
THR HG21 H N N 346 
THR HG22 H N N 347 
THR HG23 H N N 348 
THR HXT  H N N 349 
TRP N    N N N 350 
TRP CA   C N S 351 
TRP C    C N N 352 
TRP O    O N N 353 
TRP CB   C N N 354 
TRP CG   C Y N 355 
TRP CD1  C Y N 356 
TRP CD2  C Y N 357 
TRP NE1  N Y N 358 
TRP CE2  C Y N 359 
TRP CE3  C Y N 360 
TRP CZ2  C Y N 361 
TRP CZ3  C Y N 362 
TRP CH2  C Y N 363 
TRP OXT  O N N 364 
TRP H    H N N 365 
TRP H2   H N N 366 
TRP HA   H N N 367 
TRP HB2  H N N 368 
TRP HB3  H N N 369 
TRP HD1  H N N 370 
TRP HE1  H N N 371 
TRP HE3  H N N 372 
TRP HZ2  H N N 373 
TRP HZ3  H N N 374 
TRP HH2  H N N 375 
TRP HXT  H N N 376 
TYR N    N N N 377 
TYR CA   C N S 378 
TYR C    C N N 379 
TYR O    O N N 380 
TYR CB   C N N 381 
TYR CG   C Y N 382 
TYR CD1  C Y N 383 
TYR CD2  C Y N 384 
TYR CE1  C Y N 385 
TYR CE2  C Y N 386 
TYR CZ   C Y N 387 
TYR OH   O N N 388 
TYR OXT  O N N 389 
TYR H    H N N 390 
TYR H2   H N N 391 
TYR HA   H N N 392 
TYR HB2  H N N 393 
TYR HB3  H N N 394 
TYR HD1  H N N 395 
TYR HD2  H N N 396 
TYR HE1  H N N 397 
TYR HE2  H N N 398 
TYR HH   H N N 399 
TYR HXT  H N N 400 
VAL N    N N N 401 
VAL CA   C N S 402 
VAL C    C N N 403 
VAL O    O N N 404 
VAL CB   C N N 405 
VAL CG1  C N N 406 
VAL CG2  C N N 407 
VAL OXT  O N N 408 
VAL H    H N N 409 
VAL H2   H N N 410 
VAL HA   H N N 411 
VAL HB   H N N 412 
VAL HG11 H N N 413 
VAL HG12 H N N 414 
VAL HG13 H N N 415 
VAL HG21 H N N 416 
VAL HG22 H N N 417 
VAL HG23 H N N 418 
VAL HXT  H N N 419 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CH6 CE  SD   sing N N 70  
CH6 SD  CG1  sing N N 71  
CH6 CG1 CB1  sing N N 72  
CH6 OH  CZ   sing N N 73  
CH6 CB1 CA1  sing N N 74  
CH6 OXT C3   sing N N 75  
CH6 CE1 CZ   doub Y N 76  
CH6 CE1 CD1  sing Y N 77  
CH6 CZ  CE2  sing Y N 78  
CH6 CD1 CG2  doub Y N 79  
CH6 CA1 C1   sing N N 80  
CH6 CA1 N1   sing N N 81  
CH6 CE2 CD2  doub Y N 82  
CH6 N2  C1   doub N N 83  
CH6 N2  CA2  sing N N 84  
CH6 C1  N3   sing N N 85  
CH6 CG2 CD2  sing Y N 86  
CH6 CG2 CB2  sing N N 87  
CH6 C3  O3   doub N N 88  
CH6 C3  CA3  sing N N 89  
CH6 CA2 CB2  doub N N 90  
CH6 CA2 C2   sing N N 91  
CH6 N3  C2   sing N N 92  
CH6 N3  CA3  sing N N 93  
CH6 C2  O2   doub N N 94  
CH6 N1  H    sing N N 95  
CH6 N1  H2   sing N N 96  
CH6 CE  HE1A sing N N 97  
CH6 CE  HE2A sing N N 98  
CH6 CE  HE3  sing N N 99  
CH6 CG1 HG11 sing N N 100 
CH6 CG1 HG12 sing N N 101 
CH6 CB1 HB11 sing N N 102 
CH6 CB1 HB12 sing N Z 103 
CH6 CA1 HA1  sing N N 104 
CH6 OH  HOH  sing N N 105 
CH6 CD2 HD2  sing N N 106 
CH6 CE2 HE2  sing N N 107 
CH6 CE1 HE1  sing N N 108 
CH6 CD1 HD1  sing N N 109 
CH6 CB2 HB2  sing N N 110 
CH6 CA3 HA31 sing N N 111 
CH6 CA3 HA32 sing N N 112 
CH6 OXT HXT  sing N N 113 
GLN N   CA   sing N N 114 
GLN N   H    sing N N 115 
GLN N   H2   sing N N 116 
GLN CA  C    sing N N 117 
GLN CA  CB   sing N N 118 
GLN CA  HA   sing N N 119 
GLN C   O    doub N N 120 
GLN C   OXT  sing N N 121 
GLN CB  CG   sing N N 122 
GLN CB  HB2  sing N N 123 
GLN CB  HB3  sing N N 124 
GLN CG  CD   sing N N 125 
GLN CG  HG2  sing N N 126 
GLN CG  HG3  sing N N 127 
GLN CD  OE1  doub N N 128 
GLN CD  NE2  sing N N 129 
GLN NE2 HE21 sing N N 130 
GLN NE2 HE22 sing N N 131 
GLN OXT HXT  sing N N 132 
GLU N   CA   sing N N 133 
GLU N   H    sing N N 134 
GLU N   H2   sing N N 135 
GLU CA  C    sing N N 136 
GLU CA  CB   sing N N 137 
GLU CA  HA   sing N N 138 
GLU C   O    doub N N 139 
GLU C   OXT  sing N N 140 
GLU CB  CG   sing N N 141 
GLU CB  HB2  sing N N 142 
GLU CB  HB3  sing N N 143 
GLU CG  CD   sing N N 144 
GLU CG  HG2  sing N N 145 
GLU CG  HG3  sing N N 146 
GLU CD  OE1  doub N N 147 
GLU CD  OE2  sing N N 148 
GLU OE2 HE2  sing N N 149 
GLU OXT HXT  sing N N 150 
GLY N   CA   sing N N 151 
GLY N   H    sing N N 152 
GLY N   H2   sing N N 153 
GLY CA  C    sing N N 154 
GLY CA  HA2  sing N N 155 
GLY CA  HA3  sing N N 156 
GLY C   O    doub N N 157 
GLY C   OXT  sing N N 158 
GLY OXT HXT  sing N N 159 
HIS N   CA   sing N N 160 
HIS N   H    sing N N 161 
HIS N   H2   sing N N 162 
HIS CA  C    sing N N 163 
HIS CA  CB   sing N N 164 
HIS CA  HA   sing N N 165 
HIS C   O    doub N N 166 
HIS C   OXT  sing N N 167 
HIS CB  CG   sing N N 168 
HIS CB  HB2  sing N N 169 
HIS CB  HB3  sing N N 170 
HIS CG  ND1  sing Y N 171 
HIS CG  CD2  doub Y N 172 
HIS ND1 CE1  doub Y N 173 
HIS ND1 HD1  sing N N 174 
HIS CD2 NE2  sing Y N 175 
HIS CD2 HD2  sing N N 176 
HIS CE1 NE2  sing Y N 177 
HIS CE1 HE1  sing N N 178 
HIS NE2 HE2  sing N N 179 
HIS OXT HXT  sing N N 180 
HOH O   H1   sing N N 181 
HOH O   H2   sing N N 182 
ILE N   CA   sing N N 183 
ILE N   H    sing N N 184 
ILE N   H2   sing N N 185 
ILE CA  C    sing N N 186 
ILE CA  CB   sing N N 187 
ILE CA  HA   sing N N 188 
ILE C   O    doub N N 189 
ILE C   OXT  sing N N 190 
ILE CB  CG1  sing N N 191 
ILE CB  CG2  sing N N 192 
ILE CB  HB   sing N N 193 
ILE CG1 CD1  sing N N 194 
ILE CG1 HG12 sing N N 195 
ILE CG1 HG13 sing N N 196 
ILE CG2 HG21 sing N N 197 
ILE CG2 HG22 sing N N 198 
ILE CG2 HG23 sing N N 199 
ILE CD1 HD11 sing N N 200 
ILE CD1 HD12 sing N N 201 
ILE CD1 HD13 sing N N 202 
ILE OXT HXT  sing N N 203 
LEU N   CA   sing N N 204 
LEU N   H    sing N N 205 
LEU N   H2   sing N N 206 
LEU CA  C    sing N N 207 
LEU CA  CB   sing N N 208 
LEU CA  HA   sing N N 209 
LEU C   O    doub N N 210 
LEU C   OXT  sing N N 211 
LEU CB  CG   sing N N 212 
LEU CB  HB2  sing N N 213 
LEU CB  HB3  sing N N 214 
LEU CG  CD1  sing N N 215 
LEU CG  CD2  sing N N 216 
LEU CG  HG   sing N N 217 
LEU CD1 HD11 sing N N 218 
LEU CD1 HD12 sing N N 219 
LEU CD1 HD13 sing N N 220 
LEU CD2 HD21 sing N N 221 
LEU CD2 HD22 sing N N 222 
LEU CD2 HD23 sing N N 223 
LEU OXT HXT  sing N N 224 
LYS N   CA   sing N N 225 
LYS N   H    sing N N 226 
LYS N   H2   sing N N 227 
LYS CA  C    sing N N 228 
LYS CA  CB   sing N N 229 
LYS CA  HA   sing N N 230 
LYS C   O    doub N N 231 
LYS C   OXT  sing N N 232 
LYS CB  CG   sing N N 233 
LYS CB  HB2  sing N N 234 
LYS CB  HB3  sing N N 235 
LYS CG  CD   sing N N 236 
LYS CG  HG2  sing N N 237 
LYS CG  HG3  sing N N 238 
LYS CD  CE   sing N N 239 
LYS CD  HD2  sing N N 240 
LYS CD  HD3  sing N N 241 
LYS CE  NZ   sing N N 242 
LYS CE  HE2  sing N N 243 
LYS CE  HE3  sing N N 244 
LYS NZ  HZ1  sing N N 245 
LYS NZ  HZ2  sing N N 246 
LYS NZ  HZ3  sing N N 247 
LYS OXT HXT  sing N N 248 
MET N   CA   sing N N 249 
MET N   H    sing N N 250 
MET N   H2   sing N N 251 
MET CA  C    sing N N 252 
MET CA  CB   sing N N 253 
MET CA  HA   sing N N 254 
MET C   O    doub N N 255 
MET C   OXT  sing N N 256 
MET CB  CG   sing N N 257 
MET CB  HB2  sing N N 258 
MET CB  HB3  sing N N 259 
MET CG  SD   sing N N 260 
MET CG  HG2  sing N N 261 
MET CG  HG3  sing N N 262 
MET SD  CE   sing N N 263 
MET CE  HE1  sing N N 264 
MET CE  HE2  sing N N 265 
MET CE  HE3  sing N N 266 
MET OXT HXT  sing N N 267 
PHE N   CA   sing N N 268 
PHE N   H    sing N N 269 
PHE N   H2   sing N N 270 
PHE CA  C    sing N N 271 
PHE CA  CB   sing N N 272 
PHE CA  HA   sing N N 273 
PHE C   O    doub N N 274 
PHE C   OXT  sing N N 275 
PHE CB  CG   sing N N 276 
PHE CB  HB2  sing N N 277 
PHE CB  HB3  sing N N 278 
PHE CG  CD1  doub Y N 279 
PHE CG  CD2  sing Y N 280 
PHE CD1 CE1  sing Y N 281 
PHE CD1 HD1  sing N N 282 
PHE CD2 CE2  doub Y N 283 
PHE CD2 HD2  sing N N 284 
PHE CE1 CZ   doub Y N 285 
PHE CE1 HE1  sing N N 286 
PHE CE2 CZ   sing Y N 287 
PHE CE2 HE2  sing N N 288 
PHE CZ  HZ   sing N N 289 
PHE OXT HXT  sing N N 290 
PRO N   CA   sing N N 291 
PRO N   CD   sing N N 292 
PRO N   H    sing N N 293 
PRO CA  C    sing N N 294 
PRO CA  CB   sing N N 295 
PRO CA  HA   sing N N 296 
PRO C   O    doub N N 297 
PRO C   OXT  sing N N 298 
PRO CB  CG   sing N N 299 
PRO CB  HB2  sing N N 300 
PRO CB  HB3  sing N N 301 
PRO CG  CD   sing N N 302 
PRO CG  HG2  sing N N 303 
PRO CG  HG3  sing N N 304 
PRO CD  HD2  sing N N 305 
PRO CD  HD3  sing N N 306 
PRO OXT HXT  sing N N 307 
SER N   CA   sing N N 308 
SER N   H    sing N N 309 
SER N   H2   sing N N 310 
SER CA  C    sing N N 311 
SER CA  CB   sing N N 312 
SER CA  HA   sing N N 313 
SER C   O    doub N N 314 
SER C   OXT  sing N N 315 
SER CB  OG   sing N N 316 
SER CB  HB2  sing N N 317 
SER CB  HB3  sing N N 318 
SER OG  HG   sing N N 319 
SER OXT HXT  sing N N 320 
THR N   CA   sing N N 321 
THR N   H    sing N N 322 
THR N   H2   sing N N 323 
THR CA  C    sing N N 324 
THR CA  CB   sing N N 325 
THR CA  HA   sing N N 326 
THR C   O    doub N N 327 
THR C   OXT  sing N N 328 
THR CB  OG1  sing N N 329 
THR CB  CG2  sing N N 330 
THR CB  HB   sing N N 331 
THR OG1 HG1  sing N N 332 
THR CG2 HG21 sing N N 333 
THR CG2 HG22 sing N N 334 
THR CG2 HG23 sing N N 335 
THR OXT HXT  sing N N 336 
TRP N   CA   sing N N 337 
TRP N   H    sing N N 338 
TRP N   H2   sing N N 339 
TRP CA  C    sing N N 340 
TRP CA  CB   sing N N 341 
TRP CA  HA   sing N N 342 
TRP C   O    doub N N 343 
TRP C   OXT  sing N N 344 
TRP CB  CG   sing N N 345 
TRP CB  HB2  sing N N 346 
TRP CB  HB3  sing N N 347 
TRP CG  CD1  doub Y N 348 
TRP CG  CD2  sing Y N 349 
TRP CD1 NE1  sing Y N 350 
TRP CD1 HD1  sing N N 351 
TRP CD2 CE2  doub Y N 352 
TRP CD2 CE3  sing Y N 353 
TRP NE1 CE2  sing Y N 354 
TRP NE1 HE1  sing N N 355 
TRP CE2 CZ2  sing Y N 356 
TRP CE3 CZ3  doub Y N 357 
TRP CE3 HE3  sing N N 358 
TRP CZ2 CH2  doub Y N 359 
TRP CZ2 HZ2  sing N N 360 
TRP CZ3 CH2  sing Y N 361 
TRP CZ3 HZ3  sing N N 362 
TRP CH2 HH2  sing N N 363 
TRP OXT HXT  sing N N 364 
TYR N   CA   sing N N 365 
TYR N   H    sing N N 366 
TYR N   H2   sing N N 367 
TYR CA  C    sing N N 368 
TYR CA  CB   sing N N 369 
TYR CA  HA   sing N N 370 
TYR C   O    doub N N 371 
TYR C   OXT  sing N N 372 
TYR CB  CG   sing N N 373 
TYR CB  HB2  sing N N 374 
TYR CB  HB3  sing N N 375 
TYR CG  CD1  doub Y N 376 
TYR CG  CD2  sing Y N 377 
TYR CD1 CE1  sing Y N 378 
TYR CD1 HD1  sing N N 379 
TYR CD2 CE2  doub Y N 380 
TYR CD2 HD2  sing N N 381 
TYR CE1 CZ   doub Y N 382 
TYR CE1 HE1  sing N N 383 
TYR CE2 CZ   sing Y N 384 
TYR CE2 HE2  sing N N 385 
TYR CZ  OH   sing N N 386 
TYR OH  HH   sing N N 387 
TYR OXT HXT  sing N N 388 
VAL N   CA   sing N N 389 
VAL N   H    sing N N 390 
VAL N   H2   sing N N 391 
VAL CA  C    sing N N 392 
VAL CA  CB   sing N N 393 
VAL CA  HA   sing N N 394 
VAL C   O    doub N N 395 
VAL C   OXT  sing N N 396 
VAL CB  CG1  sing N N 397 
VAL CB  CG2  sing N N 398 
VAL CB  HB   sing N N 399 
VAL CG1 HG11 sing N N 400 
VAL CG1 HG12 sing N N 401 
VAL CG1 HG13 sing N N 402 
VAL CG2 HG21 sing N N 403 
VAL CG2 HG22 sing N N 404 
VAL CG2 HG23 sing N N 405 
VAL OXT HXT  sing N N 406 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministry of Education, Youth and Sports of the Czech Republic' 'Czech Republic' CZ.02.1.01/0.0/0.0/16_019/0000729 1 
'Czech Science Foundation'                                      'Czech Republic' 23-05983S                         2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2QLG 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9FER 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016308 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012862 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010341 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 38  ? 5.073   -25.443 9.042   1.00 45.34 ? 6   GLU A N   1 
ATOM   2    C CA  . GLU A 1 38  ? 5.579   -26.831 9.135   1.00 45.87 ? 6   GLU A CA  1 
ATOM   3    C C   . GLU A 1 38  ? 5.876   -27.425 7.737   1.00 36.39 ? 6   GLU A C   1 
ATOM   4    O O   . GLU A 1 38  ? 6.948   -28.043 7.640   1.00 47.38 ? 6   GLU A O   1 
ATOM   5    C CB  . GLU A 1 38  ? 4.620   -27.716 9.937   1.00 48.12 ? 6   GLU A CB  1 
ATOM   6    C CG  . GLU A 1 38  ? 5.256   -29.027 10.352  1.00 52.91 ? 6   GLU A CG  1 
ATOM   7    C CD  . GLU A 1 38  ? 4.485   -29.860 11.359  1.00 59.70 ? 6   GLU A CD  1 
ATOM   8    O OE1 . GLU A 1 38  ? 3.380   -29.444 11.798  1.00 62.87 ? 6   GLU A OE1 1 
ATOM   9    O OE2 . GLU A 1 38  ? 4.993   -30.934 11.697  1.00 68.70 ? 6   GLU A OE2 1 
ATOM   10   N N   . VAL A 1 39  ? 5.002   -27.340 6.710   1.00 28.77 ? 7   VAL A N   1 
ATOM   11   C CA  . VAL A 1 39  ? 5.348   -27.923 5.375   1.00 26.93 ? 7   VAL A CA  1 
ATOM   12   C C   . VAL A 1 39  ? 6.458   -27.059 4.753   1.00 22.99 ? 7   VAL A C   1 
ATOM   13   O O   . VAL A 1 39  ? 7.295   -27.614 4.080   1.00 23.40 ? 7   VAL A O   1 
ATOM   14   C CB  . VAL A 1 39  ? 4.160   -28.079 4.403   1.00 31.63 ? 7   VAL A CB  1 
ATOM   15   C CG1 . VAL A 1 39  ? 3.188   -29.151 4.890   1.00 35.89 ? 7   VAL A CG1 1 
ATOM   16   C CG2 . VAL A 1 39  ? 3.437   -26.780 4.093   1.00 30.29 ? 7   VAL A CG2 1 
ATOM   17   N N   . ILE A 1 40  ? 6.460   -25.727 4.940   1.00 16.03 ? 8   ILE A N   1 
ATOM   18   C CA  . ILE A 1 40  ? 7.593   -24.910 4.414   1.00 16.36 ? 8   ILE A CA  1 
ATOM   19   C C   . ILE A 1 40  ? 8.662   -24.832 5.481   1.00 14.63 ? 8   ILE A C   1 
ATOM   20   O O   . ILE A 1 40  ? 8.511   -24.088 6.460   1.00 15.66 ? 8   ILE A O   1 
ATOM   21   C CB  . ILE A 1 40  ? 7.199   -23.517 3.893   1.00 14.04 ? 8   ILE A CB  1 
ATOM   22   C CG1 . ILE A 1 40  ? 6.202   -23.634 2.740   1.00 14.50 ? 8   ILE A CG1 1 
ATOM   23   C CG2 . ILE A 1 40  ? 8.439   -22.803 3.428   1.00 15.84 ? 8   ILE A CG2 1 
ATOM   24   C CD1 . ILE A 1 40  ? 5.565   -22.288 2.357   1.00 13.83 ? 8   ILE A CD1 1 
ATOM   25   N N   . LYS A 1 41  ? 9.706   -25.627 5.308   1.00 16.56 ? 9   LYS A N   1 
ATOM   26   C CA  . LYS A 1 41  ? 10.850  -25.635 6.244   1.00 19.48 ? 9   LYS A CA  1 
ATOM   27   C C   . LYS A 1 41  ? 11.735  -24.407 6.022   1.00 19.24 ? 9   LYS A C   1 
ATOM   28   O O   . LYS A 1 41  ? 11.573  -23.674 5.008   1.00 17.22 ? 9   LYS A O   1 
ATOM   29   C CB  . LYS A 1 41  ? 11.683  -26.906 6.067   1.00 22.40 ? 9   LYS A CB  1 
ATOM   30   C CG  . LYS A 1 41  ? 10.906  -28.209 6.174   1.00 27.97 ? 9   LYS A CG  1 
ATOM   31   C CD  . LYS A 1 41  ? 11.729  -29.448 5.881   1.00 32.54 ? 9   LYS A CD  1 
ATOM   32   C CE  . LYS A 1 41  ? 13.027  -29.554 6.671   1.00 40.26 ? 9   LYS A CE  1 
ATOM   33   N NZ  . LYS A 1 41  ? 12.795  -30.008 8.064   1.00 43.76 ? 9   LYS A NZ  1 
ATOM   34   N N   . GLU A 1 42  ? 12.702  -24.193 6.924   1.00 17.78 ? 10  GLU A N   1 
ATOM   35   C CA  . GLU A 1 42  ? 13.612  -23.009 6.848   1.00 16.46 ? 10  GLU A CA  1 
ATOM   36   C C   . GLU A 1 42  ? 14.555  -23.134 5.663   1.00 14.19 ? 10  GLU A C   1 
ATOM   37   O O   . GLU A 1 42  ? 15.013  -22.114 5.208   1.00 15.67 ? 10  GLU A O   1 
ATOM   38   C CB  . GLU A 1 42  ? 14.452  -22.811 8.105   1.00 18.51 ? 10  GLU A CB  1 
ATOM   39   C CG  . GLU A 1 42  ? 13.626  -22.262 9.272   1.00 25.27 ? 10  GLU A CG  1 
ATOM   40   C CD  . GLU A 1 42  ? 14.390  -22.077 10.574  1.00 29.66 ? 10  GLU A CD  1 
ATOM   41   O OE1 . GLU A 1 42  ? 14.857  -20.960 10.794  1.00 37.73 ? 10  GLU A OE1 1 
ATOM   42   O OE2 . GLU A 1 42  ? 14.541  -23.058 11.343  1.00 38.51 ? 10  GLU A OE2 1 
ATOM   43   N N   . PHE A 1 43  ? 14.781  -24.333 5.165   1.00 12.99 ? 11  PHE A N   1 
ATOM   44   C CA  . PHE A 1 43  ? 15.548  -24.624 3.924   1.00 14.16 ? 11  PHE A CA  1 
ATOM   45   C C   . PHE A 1 43  ? 14.597  -25.433 3.019   1.00 15.44 ? 11  PHE A C   1 
ATOM   46   O O   . PHE A 1 43  ? 14.068  -26.509 3.405   1.00 16.47 ? 11  PHE A O   1 
ATOM   47   C CB  . PHE A 1 43  ? 16.873  -25.377 4.225   1.00 15.77 ? 11  PHE A CB  1 
ATOM   48   C CG  . PHE A 1 43  ? 17.638  -25.803 2.988   1.00 14.64 ? 11  PHE A CG  1 
ATOM   49   C CD1 . PHE A 1 43  ? 18.440  -24.896 2.300   1.00 17.83 ? 11  PHE A CD1 1 
ATOM   50   C CD2 . PHE A 1 43  ? 17.580  -27.112 2.540   1.00 17.18 ? 11  PHE A CD2 1 
ATOM   51   C CE1 . PHE A 1 43  ? 19.144  -25.298 1.182   1.00 15.86 ? 11  PHE A CE1 1 
ATOM   52   C CE2 . PHE A 1 43  ? 18.258  -27.520 1.406   1.00 16.55 ? 11  PHE A CE2 1 
ATOM   53   C CZ  . PHE A 1 43  ? 19.058  -26.601 0.754   1.00 17.12 ? 11  PHE A CZ  1 
ATOM   54   N N   . MET A 1 44  ? 14.455  -25.007 1.783   1.00 13.10 ? 12  MET A N   1 
ATOM   55   C CA  . MET A 1 44  ? 13.609  -25.715 0.821   1.00 13.91 ? 12  MET A CA  1 
ATOM   56   C C   . MET A 1 44  ? 14.314  -25.714 -0.540  1.00 13.09 ? 12  MET A C   1 
ATOM   57   O O   . MET A 1 44  ? 14.752  -24.637 -1.009  1.00 12.43 ? 12  MET A O   1 
ATOM   58   C CB  . MET A 1 44  ? 12.236  -25.046 0.657   1.00 13.61 ? 12  MET A CB  1 
ATOM   59   C CG  . MET A 1 44  ? 11.310  -25.128 1.877   1.00 13.92 ? 12  MET A CG  1 
ATOM   60   S SD  . MET A 1 44  ? 10.824  -26.816 2.233   1.00 15.91 ? 12  MET A SD  1 
ATOM   61   C CE  . MET A 1 44  ? 9.591   -26.968 0.941   1.00 16.90 ? 12  MET A CE  1 
ATOM   62   N N   . ARG A 1 45  ? 14.239  -26.836 -1.212  1.00 12.55 ? 13  ARG A N   1 
ATOM   63   C CA  . ARG A 1 45  ? 14.637  -26.983 -2.618  1.00 14.91 ? 13  ARG A CA  1 
ATOM   64   C C   . ARG A 1 45  ? 13.393  -26.833 -3.506  1.00 14.60 ? 13  ARG A C   1 
ATOM   65   O O   . ARG A 1 45  ? 12.256  -27.078 -3.061  1.00 14.25 ? 13  ARG A O   1 
ATOM   66   C CB  . ARG A 1 45  ? 15.322  -28.341 -2.827  1.00 14.96 ? 13  ARG A CB  1 
ATOM   67   C CG  . ARG A 1 45  ? 16.654  -28.503 -2.105  1.00 16.96 ? 13  ARG A CG  1 
ATOM   68   C CD  . ARG A 1 45  ? 17.349  -29.835 -2.432  1.00 17.96 ? 13  ARG A CD  1 
ATOM   69   N NE  . ARG A 1 45  ? 18.662  -29.792 -1.806  1.00 19.61 ? 13  ARG A NE  1 
ATOM   70   C CZ  . ARG A 1 45  ? 19.766  -29.227 -2.311  1.00 20.15 ? 13  ARG A CZ  1 
ATOM   71   N NH1 . ARG A 1 45  ? 19.784  -28.602 -3.483  1.00 22.49 ? 13  ARG A NH1 1 
ATOM   72   N NH2 . ARG A 1 45  ? 20.840  -29.232 -1.565  1.00 24.09 ? 13  ARG A NH2 1 
ATOM   73   N N   . PHE A 1 46  ? 13.638  -26.554 -4.783  1.00 13.71 ? 14  PHE A N   1 
ATOM   74   C CA  . PHE A 1 46  ? 12.592  -26.542 -5.809  1.00 14.75 ? 14  PHE A CA  1 
ATOM   75   C C   . PHE A 1 46  ? 13.115  -27.157 -7.098  1.00 13.98 ? 14  PHE A C   1 
ATOM   76   O O   . PHE A 1 46  ? 14.390  -27.207 -7.307  1.00 13.16 ? 14  PHE A O   1 
ATOM   77   C CB  . PHE A 1 46  ? 12.057  -25.114 -6.030  1.00 13.83 ? 14  PHE A CB  1 
ATOM   78   C CG  . PHE A 1 46  ? 12.902  -24.110 -6.749  1.00 14.17 ? 14  PHE A CG  1 
ATOM   79   C CD1 . PHE A 1 46  ? 13.029  -24.118 -8.123  1.00 14.57 ? 14  PHE A CD1 1 
ATOM   80   C CD2 . PHE A 1 46  ? 13.512  -23.091 -6.031  1.00 14.80 ? 14  PHE A CD2 1 
ATOM   81   C CE1 . PHE A 1 46  ? 13.773  -23.132 -8.763  1.00 14.58 ? 14  PHE A CE1 1 
ATOM   82   C CE2 . PHE A 1 46  ? 14.219  -22.089 -6.675  1.00 14.26 ? 14  PHE A CE2 1 
ATOM   83   C CZ  . PHE A 1 46  ? 14.355  -22.115 -8.041  1.00 13.90 ? 14  PHE A CZ  1 
ATOM   84   N N   . LYS A 1 47  ? 12.168  -27.615 -7.909  1.00 13.75 ? 15  LYS A N   1 
ATOM   85   C CA  . LYS A 1 47  ? 12.447  -28.102 -9.275  1.00 17.67 ? 15  LYS A CA  1 
ATOM   86   C C   . LYS A 1 47  ? 11.587  -27.279 -10.220 1.00 17.39 ? 15  LYS A C   1 
ATOM   87   O O   . LYS A 1 47  ? 10.419  -27.075 -9.904  1.00 15.19 ? 15  LYS A O   1 
ATOM   88   C CB  . LYS A 1 47  ? 12.190  -29.616 -9.371  1.00 21.43 ? 15  LYS A CB  1 
ATOM   89   C CG  . LYS A 1 47  ? 12.917  -30.481 -8.340  1.00 28.63 ? 15  LYS A CG  1 
ATOM   90   C CD  . LYS A 1 47  ? 14.352  -30.899 -8.732  1.00 37.64 ? 15  LYS A CD  1 
ATOM   91   C CE  . LYS A 1 47  ? 15.210  -31.589 -7.666  1.00 41.27 ? 15  LYS A CE  1 
ATOM   92   N NZ  . LYS A 1 47  ? 15.746  -30.646 -6.624  1.00 43.81 ? 15  LYS A NZ  1 
ATOM   93   N N   . GLU A 1 48  ? 12.109  -26.929 -11.395 1.00 15.36 ? 16  GLU A N   1 
ATOM   94   C CA  . GLU A 1 48  ? 11.358  -26.096 -12.343 1.00 16.37 ? 16  GLU A CA  1 
ATOM   95   C C   . GLU A 1 48  ? 11.440  -26.669 -13.739 1.00 15.35 ? 16  GLU A C   1 
ATOM   96   O O   . GLU A 1 48  ? 12.501  -27.125 -14.133 1.00 17.70 ? 16  GLU A O   1 
ATOM   97   C CB  . GLU A 1 48  ? 11.881  -24.677 -12.303 1.00 17.93 ? 16  GLU A CB  1 
ATOM   98   C CG  . GLU A 1 48  ? 11.101  -23.805 -13.258 1.00 17.99 ? 16  GLU A CG  1 
ATOM   99   C CD  . GLU A 1 48  ? 11.340  -22.340 -13.046 1.00 19.74 ? 16  GLU A CD  1 
ATOM   100  O OE1 . GLU A 1 48  ? 11.546  -21.979 -11.883 1.00 20.69 ? 16  GLU A OE1 1 
ATOM   101  O OE2 . GLU A 1 48  ? 11.318  -21.556 -14.053 1.00 19.24 ? 16  GLU A OE2 1 
ATOM   102  N N   . HIS A 1 49  ? 10.305  -26.700 -14.413 1.00 14.03 ? 17  HIS A N   1 
ATOM   103  C CA  . HIS A 1 49  ? 10.241  -26.896 -15.856 1.00 15.30 ? 17  HIS A CA  1 
ATOM   104  C C   . HIS A 1 49  ? 9.555   -25.660 -16.456 1.00 16.40 ? 17  HIS A C   1 
ATOM   105  O O   . HIS A 1 49  ? 8.453   -25.277 -15.968 1.00 16.67 ? 17  HIS A O   1 
ATOM   106  C CB  . HIS A 1 49  ? 9.496   -28.201 -16.170 1.00 18.44 ? 17  HIS A CB  1 
ATOM   107  C CG  . HIS A 1 49  ? 9.316   -28.383 -17.637 1.00 20.19 ? 17  HIS A CG  1 
ATOM   108  N ND1 . HIS A 1 49  ? 8.178   -27.909 -18.312 1.00 22.89 ? 17  HIS A ND1 1 
ATOM   109  C CD2 . HIS A 1 49  ? 10.158  -28.863 -18.583 1.00 23.60 ? 17  HIS A CD2 1 
ATOM   110  C CE1 . HIS A 1 49  ? 8.309   -28.143 -19.601 1.00 21.44 ? 17  HIS A CE1 1 
ATOM   111  N NE2 . HIS A 1 49  ? 9.535   -28.722 -19.811 1.00 22.06 ? 17  HIS A NE2 1 
ATOM   112  N N   . MET A 1 50  ? 10.088  -25.216 -17.584 1.00 15.84 ? 18  MET A N   1 
ATOM   113  C CA  . MET A 1 50  ? 9.610   -24.056 -18.355 1.00 16.13 ? 18  MET A CA  1 
ATOM   114  C C   . MET A 1 50  ? 9.561   -24.481 -19.819 1.00 17.98 ? 18  MET A C   1 
ATOM   115  O O   . MET A 1 50  ? 10.501  -25.149 -20.279 1.00 16.22 ? 18  MET A O   1 
ATOM   116  C CB  . MET A 1 50  ? 10.586  -22.887 -18.208 1.00 15.53 ? 18  MET A CB  1 
ATOM   117  C CG  . MET A 1 50  ? 10.308  -21.757 -19.145 1.00 15.89 ? 18  MET A CG  1 
ATOM   118  S SD  . MET A 1 50  ? 11.341  -20.309 -18.909 1.00 18.05 ? 18  MET A SD  1 
ATOM   119  C CE  . MET A 1 50  ? 10.852  -19.647 -17.315 1.00 17.69 ? 18  MET A CE  1 
ATOM   120  N N   . GLU A 1 51  ? 8.500   -24.086 -20.515 1.00 18.63 ? 19  GLU A N   1 
ATOM   121  C CA  . GLU A 1 51  ? 8.362   -24.311 -21.966 1.00 20.69 ? 19  GLU A CA  1 
ATOM   122  C C   . GLU A 1 51  ? 7.833   -23.001 -22.517 1.00 19.20 ? 19  GLU A C   1 
ATOM   123  O O   . GLU A 1 51  ? 7.124   -22.270 -21.788 1.00 18.60 ? 19  GLU A O   1 
ATOM   124  C CB  . GLU A 1 51  ? 7.488   -25.543 -22.209 1.00 23.12 ? 19  GLU A CB  1 
ATOM   125  C CG  . GLU A 1 51  ? 5.995   -25.228 -22.186 1.00 25.88 ? 19  GLU A CG  1 
ATOM   126  C CD  . GLU A 1 51  ? 5.037   -26.406 -22.215 1.00 32.07 ? 19  GLU A CD  1 
ATOM   127  O OE1 . GLU A 1 51  ? 3.875   -26.217 -22.655 1.00 38.03 ? 19  GLU A OE1 1 
ATOM   128  O OE2 . GLU A 1 51  ? 5.421   -27.462 -21.716 1.00 32.69 ? 19  GLU A OE2 1 
ATOM   129  N N   . GLY A 1 52  ? 8.186   -22.672 -23.744 1.00 17.38 ? 20  GLY A N   1 
ATOM   130  C CA  . GLY A 1 52  ? 7.554   -21.519 -24.375 1.00 17.56 ? 20  GLY A CA  1 
ATOM   131  C C   . GLY A 1 52  ? 8.199   -21.230 -25.681 1.00 17.23 ? 20  GLY A C   1 
ATOM   132  O O   . GLY A 1 52  ? 8.906   -22.163 -26.245 1.00 17.57 ? 20  GLY A O   1 
ATOM   133  N N   . SER A 1 53  ? 8.044   -19.988 -26.080 1.00 19.10 ? 21  SER A N   1 
ATOM   134  C CA  . SER A 1 53  ? 8.590   -19.471 -27.345 1.00 16.05 ? 21  SER A CA  1 
ATOM   135  C C   . SER A 1 53  ? 8.690   -17.979 -27.229 1.00 17.79 ? 21  SER A C   1 
ATOM   136  O O   . SER A 1 53  ? 7.865   -17.367 -26.589 1.00 17.22 ? 21  SER A O   1 
ATOM   137  C CB  . SER A 1 53  ? 7.761   -19.876 -28.562 1.00 17.35 ? 21  SER A CB  1 
ATOM   138  O OG  . SER A 1 53  ? 6.448   -19.372 -28.494 1.00 20.24 ? 21  SER A OG  1 
ATOM   139  N N   . VAL A 1 54  ? 9.678   -17.439 -27.901 1.00 17.05 ? 22  VAL A N   1 
ATOM   140  C CA  . VAL A 1 54  ? 9.914   -15.985 -27.999 1.00 17.17 ? 22  VAL A CA  1 
ATOM   141  C C   . VAL A 1 54  ? 10.191  -15.711 -29.482 1.00 19.70 ? 22  VAL A C   1 
ATOM   142  O O   . VAL A 1 54  ? 11.061  -16.391 -30.052 1.00 19.62 ? 22  VAL A O   1 
ATOM   143  C CB  . VAL A 1 54  ? 11.069  -15.586 -27.076 1.00 17.08 ? 22  VAL A CB  1 
ATOM   144  C CG1 . VAL A 1 54  ? 11.450  -14.146 -27.335 1.00 15.93 ? 22  VAL A CG1 1 
ATOM   145  C CG2 . VAL A 1 54  ? 10.680  -15.750 -25.600 1.00 17.93 ? 22  VAL A CG2 1 
ATOM   146  N N   . ASN A 1 55  ? 9.426   -14.825 -30.117 1.00 20.36 ? 23  ASN A N   1 
ATOM   147  C CA  . ASN A 1 55  ? 9.587   -14.528 -31.572 1.00 20.54 ? 23  ASN A CA  1 
ATOM   148  C C   . ASN A 1 55  ? 9.688   -15.816 -32.408 1.00 20.36 ? 23  ASN A C   1 
ATOM   149  O O   . ASN A 1 55  ? 10.580  -15.929 -33.274 1.00 20.80 ? 23  ASN A O   1 
ATOM   150  C CB  . ASN A 1 55  ? 10.794  -13.615 -31.737 1.00 21.65 ? 23  ASN A CB  1 
ATOM   151  C CG  . ASN A 1 55  ? 10.454  -12.166 -31.524 1.00 19.43 ? 23  ASN A CG  1 
ATOM   152  O OD1 . ASN A 1 55  ? 9.576   -11.825 -30.731 1.00 19.42 ? 23  ASN A OD1 1 
ATOM   153  N ND2 . ASN A 1 55  ? 11.098  -11.296 -32.274 1.00 19.87 ? 23  ASN A ND2 1 
ATOM   154  N N   . GLY A 1 56  ? 8.841   -16.813 -32.152 1.00 21.81 ? 24  GLY A N   1 
ATOM   155  C CA  . GLY A 1 56  ? 8.761   -18.071 -32.930 1.00 21.20 ? 24  GLY A CA  1 
ATOM   156  C C   . GLY A 1 56  ? 9.774   -19.132 -32.516 1.00 22.47 ? 24  GLY A C   1 
ATOM   157  O O   . GLY A 1 56  ? 9.715   -20.271 -33.029 1.00 23.81 ? 24  GLY A O   1 
ATOM   158  N N   . HIS A 1 57  ? 10.631  -18.847 -31.543 1.00 19.37 ? 25  HIS A N   1 
ATOM   159  C CA  . HIS A 1 57  ? 11.704  -19.797 -31.168 1.00 19.80 ? 25  HIS A CA  1 
ATOM   160  C C   . HIS A 1 57  ? 11.272  -20.576 -29.948 1.00 18.17 ? 25  HIS A C   1 
ATOM   161  O O   . HIS A 1 57  ? 11.115  -19.985 -28.916 1.00 17.17 ? 25  HIS A O   1 
ATOM   162  C CB  . HIS A 1 57  ? 13.008  -19.039 -30.945 1.00 22.25 ? 25  HIS A CB  1 
ATOM   163  C CG  . HIS A 1 57  ? 14.146  -19.981 -30.832 1.00 26.32 ? 25  HIS A CG  1 
ATOM   164  N ND1 . HIS A 1 57  ? 14.410  -20.662 -29.637 1.00 29.23 ? 25  HIS A ND1 1 
ATOM   165  C CD2 . HIS A 1 57  ? 15.039  -20.421 -31.757 1.00 24.90 ? 25  HIS A CD2 1 
ATOM   166  C CE1 . HIS A 1 57  ? 15.467  -21.435 -29.811 1.00 25.27 ? 25  HIS A CE1 1 
ATOM   167  N NE2 . HIS A 1 57  ? 15.860  -21.305 -31.109 1.00 29.08 ? 25  HIS A NE2 1 
ATOM   168  N N   . GLU A 1 58  ? 10.979  -21.840 -30.108 1.00 18.78 ? 26  GLU A N   1 
ATOM   169  C CA  . GLU A 1 58  ? 10.491  -22.716 -29.031 1.00 20.60 ? 26  GLU A CA  1 
ATOM   170  C C   . GLU A 1 58  ? 11.677  -23.204 -28.215 1.00 20.22 ? 26  GLU A C   1 
ATOM   171  O O   . GLU A 1 58  ? 12.748  -23.465 -28.820 1.00 19.50 ? 26  GLU A O   1 
ATOM   172  C CB  . GLU A 1 58  ? 9.776   -23.923 -29.606 1.00 22.67 ? 26  GLU A CB  1 
ATOM   173  C CG  . GLU A 1 58  ? 8.640   -23.474 -30.506 1.00 29.50 ? 26  GLU A CG  1 
ATOM   174  C CD  . GLU A 1 58  ? 7.350   -24.193 -30.248 1.00 38.78 ? 26  GLU A CD  1 
ATOM   175  O OE1 . GLU A 1 58  ? 7.299   -25.404 -30.614 1.00 44.00 ? 26  GLU A OE1 1 
ATOM   176  O OE2 . GLU A 1 58  ? 6.410   -23.527 -29.663 1.00 49.10 ? 26  GLU A OE2 1 
ATOM   177  N N   . PHE A 1 59  ? 11.440  -23.500 -26.937 1.00 18.64 ? 27  PHE A N   1 
ATOM   178  C CA  . PHE A 1 59  ? 12.502  -23.982 -26.009 1.00 17.94 ? 27  PHE A CA  1 
ATOM   179  C C   . PHE A 1 59  ? 11.889  -24.663 -24.796 1.00 18.92 ? 27  PHE A C   1 
ATOM   180  O O   . PHE A 1 59  ? 10.648  -24.486 -24.525 1.00 17.06 ? 27  PHE A O   1 
ATOM   181  C CB  . PHE A 1 59  ? 13.371  -22.796 -25.555 1.00 18.97 ? 27  PHE A CB  1 
ATOM   182  C CG  . PHE A 1 59  ? 12.630  -21.750 -24.770 1.00 18.45 ? 27  PHE A CG  1 
ATOM   183  C CD1 . PHE A 1 59  ? 11.997  -20.718 -25.422 1.00 19.52 ? 27  PHE A CD1 1 
ATOM   184  C CD2 . PHE A 1 59  ? 12.546  -21.810 -23.390 1.00 19.96 ? 27  PHE A CD2 1 
ATOM   185  C CE1 . PHE A 1 59  ? 11.282  -19.763 -24.731 1.00 21.75 ? 27  PHE A CE1 1 
ATOM   186  C CE2 . PHE A 1 59  ? 11.846  -20.844 -22.678 1.00 20.20 ? 27  PHE A CE2 1 
ATOM   187  C CZ  . PHE A 1 59  ? 11.194  -19.833 -23.344 1.00 20.80 ? 27  PHE A CZ  1 
ATOM   188  N N   . GLU A 1 60  ? 12.709  -25.466 -24.098 1.00 17.86 ? 28  GLU A N   1 
ATOM   189  C CA  . GLU A 1 60  ? 12.407  -25.940 -22.725 1.00 18.76 ? 28  GLU A CA  1 
ATOM   190  C C   . GLU A 1 60  ? 13.627  -25.682 -21.849 1.00 17.37 ? 28  GLU A C   1 
ATOM   191  O O   . GLU A 1 60  ? 14.797  -25.818 -22.357 1.00 19.11 ? 28  GLU A O   1 
ATOM   192  C CB  . GLU A 1 60  ? 12.051  -27.432 -22.694 1.00 22.06 ? 28  GLU A CB  1 
ATOM   193  C CG  . GLU A 1 60  ? 10.868  -27.763 -23.577 1.00 23.01 ? 28  GLU A CG  1 
ATOM   194  C CD  . GLU A 1 60  ? 10.284  -29.146 -23.388 1.00 25.71 ? 28  GLU A CD  1 
ATOM   195  O OE1 . GLU A 1 60  ? 10.612  -29.823 -22.393 1.00 24.79 ? 28  GLU A OE1 1 
ATOM   196  O OE2 . GLU A 1 60  ? 9.415   -29.490 -24.183 1.00 27.63 ? 28  GLU A OE2 1 
ATOM   197  N N   . ILE A 1 61  ? 13.364  -25.383 -20.588 1.00 15.57 ? 29  ILE A N   1 
ATOM   198  C CA  . ILE A 1 61  ? 14.395  -25.145 -19.544 1.00 16.25 ? 29  ILE A CA  1 
ATOM   199  C C   . ILE A 1 61  ? 14.004  -25.974 -18.328 1.00 15.62 ? 29  ILE A C   1 
ATOM   200  O O   . ILE A 1 61  ? 12.788  -26.072 -18.023 1.00 16.59 ? 29  ILE A O   1 
ATOM   201  C CB  . ILE A 1 61  ? 14.543  -23.635 -19.234 1.00 15.53 ? 29  ILE A CB  1 
ATOM   202  C CG1 . ILE A 1 61  ? 15.254  -22.910 -20.373 1.00 17.19 ? 29  ILE A CG1 1 
ATOM   203  C CG2 . ILE A 1 61  ? 15.238  -23.403 -17.883 1.00 16.34 ? 29  ILE A CG2 1 
ATOM   204  C CD1 . ILE A 1 61  ? 15.004  -21.402 -20.369 1.00 16.14 ? 29  ILE A CD1 1 
ATOM   205  N N   . GLU A 1 62  ? 14.998  -26.602 -17.710 1.00 15.29 ? 30  GLU A N   1 
ATOM   206  C CA  . GLU A 1 62  ? 14.823  -27.271 -16.402 1.00 17.19 ? 30  GLU A CA  1 
ATOM   207  C C   . GLU A 1 62  ? 15.767  -26.644 -15.393 1.00 15.84 ? 30  GLU A C   1 
ATOM   208  O O   . GLU A 1 62  ? 16.838  -26.210 -15.747 1.00 15.28 ? 30  GLU A O   1 
ATOM   209  C CB  . GLU A 1 62  ? 15.057  -28.777 -16.491 1.00 17.59 ? 30  GLU A CB  1 
ATOM   210  C CG  . GLU A 1 62  ? 13.949  -29.396 -17.305 1.00 19.93 ? 30  GLU A CG  1 
ATOM   211  C CD  . GLU A 1 62  ? 13.910  -30.912 -17.390 1.00 22.01 ? 30  GLU A CD  1 
ATOM   212  O OE1 . GLU A 1 62  ? 13.020  -31.436 -18.048 1.00 23.04 ? 30  GLU A OE1 1 
ATOM   213  O OE2 . GLU A 1 62  ? 14.775  -31.505 -16.851 1.00 24.24 ? 30  GLU A OE2 1 
ATOM   214  N N   . GLY A 1 63  ? 15.384  -26.695 -14.142 1.00 16.91 ? 31  GLY A N   1 
ATOM   215  C CA  . GLY A 1 63  ? 16.305  -26.224 -13.114 1.00 17.34 ? 31  GLY A CA  1 
ATOM   216  C C   . GLY A 1 63  ? 16.081  -26.867 -11.806 1.00 16.21 ? 31  GLY A C   1 
ATOM   217  O O   . GLY A 1 63  ? 15.013  -27.464 -11.581 1.00 16.56 ? 31  GLY A O   1 
ATOM   218  N N   . GLU A 1 64  ? 17.072  -26.683 -10.956 1.00 16.52 ? 32  GLU A N   1 
ATOM   219  C CA  . GLU A 1 64  ? 16.985  -27.078 -9.542  1.00 14.07 ? 32  GLU A CA  1 
ATOM   220  C C   . GLU A 1 64  ? 17.485  -25.889 -8.730  1.00 15.05 ? 32  GLU A C   1 
ATOM   221  O O   . GLU A 1 64  ? 18.511  -25.289 -9.077  1.00 13.87 ? 32  GLU A O   1 
ATOM   222  C CB  . GLU A 1 64  ? 17.703  -28.419 -9.294  1.00 14.89 ? 32  GLU A CB  1 
ATOM   223  C CG  . GLU A 1 64  ? 19.192  -28.402 -9.526  1.00 15.96 ? 32  GLU A CG  1 
ATOM   224  C CD  . GLU A 1 64  ? 20.045  -27.775 -8.422  1.00 15.09 ? 32  GLU A CD  1 
ATOM   225  O OE1 . GLU A 1 64  ? 19.533  -27.536 -7.276  1.00 16.73 ? 32  GLU A OE1 1 
ATOM   226  O OE2 . GLU A 1 64  ? 21.238  -27.519 -8.723  1.00 16.70 ? 32  GLU A OE2 1 
ATOM   227  N N   . GLY A 1 65  ? 16.791  -25.607 -7.621  1.00 15.23 ? 33  GLY A N   1 
ATOM   228  C CA  . GLY A 1 65  ? 17.229  -24.508 -6.762  1.00 12.54 ? 33  GLY A CA  1 
ATOM   229  C C   . GLY A 1 65  ? 17.028  -24.824 -5.297  1.00 12.79 ? 33  GLY A C   1 
ATOM   230  O O   . GLY A 1 65  ? 16.522  -25.919 -4.974  1.00 12.41 ? 33  GLY A O   1 
ATOM   231  N N   . GLU A 1 66  ? 17.472  -23.912 -4.455  1.00 12.30 ? 34  GLU A N   1 
ATOM   232  C CA  . GLU A 1 66  ? 17.470  -24.059 -2.987  1.00 12.92 ? 34  GLU A CA  1 
ATOM   233  C C   . GLU A 1 66  ? 17.375  -22.651 -2.407  1.00 12.78 ? 34  GLU A C   1 
ATOM   234  O O   . GLU A 1 66  ? 17.907  -21.657 -2.996  1.00 13.46 ? 34  GLU A O   1 
ATOM   235  C CB  . GLU A 1 66  ? 18.681  -24.816 -2.454  1.00 13.01 ? 34  GLU A CB  1 
ATOM   236  C CG  . GLU A 1 66  ? 19.978  -24.058 -2.556  1.00 14.42 ? 34  GLU A CG  1 
ATOM   237  C CD  . GLU A 1 66  ? 21.171  -24.970 -2.624  1.00 15.96 ? 34  GLU A CD  1 
ATOM   238  O OE1 . GLU A 1 66  ? 21.526  -25.357 -3.746  1.00 16.51 ? 34  GLU A OE1 1 
ATOM   239  O OE2 . GLU A 1 66  ? 21.771  -25.223 -1.582  1.00 14.87 ? 34  GLU A OE2 1 
ATOM   240  N N   . GLY A 1 67  ? 16.821  -22.524 -1.219  1.00 13.97 ? 35  GLY A N   1 
ATOM   241  C CA  . GLY A 1 67  ? 16.803  -21.203 -0.581  1.00 12.57 ? 35  GLY A CA  1 
ATOM   242  C C   . GLY A 1 67  ? 16.211  -21.272 0.808   1.00 12.45 ? 35  GLY A C   1 
ATOM   243  O O   . GLY A 1 67  ? 15.915  -22.399 1.329   1.00 12.03 ? 35  GLY A O   1 
ATOM   244  N N   . ARG A 1 68  ? 15.975  -20.096 1.383   1.00 12.59 ? 36  ARG A N   1 
ATOM   245  C CA  . ARG A 1 68  ? 15.526  -19.976 2.774   1.00 13.07 ? 36  ARG A CA  1 
ATOM   246  C C   . ARG A 1 68  ? 14.253  -19.155 2.725   1.00 13.48 ? 36  ARG A C   1 
ATOM   247  O O   . ARG A 1 68  ? 14.330  -17.934 2.588   1.00 11.03 ? 36  ARG A O   1 
ATOM   248  C CB  . ARG A 1 68  ? 16.637  -19.319 3.595   1.00 14.31 ? 36  ARG A CB  1 
ATOM   249  C CG  . ARG A 1 68  ? 17.879  -20.186 3.698   1.00 15.96 ? 36  ARG A CG  1 
ATOM   250  C CD  . ARG A 1 68  ? 19.052  -19.431 4.223   1.00 17.80 ? 36  ARG A CD  1 
ATOM   251  N NE  . ARG A 1 68  ? 20.264  -20.232 4.099   1.00 19.44 ? 36  ARG A NE  1 
ATOM   252  C CZ  . ARG A 1 68  ? 21.496  -19.750 4.225   1.00 18.07 ? 36  ARG A CZ  1 
ATOM   253  N NH1 . ARG A 1 68  ? 21.699  -18.488 4.590   1.00 16.50 ? 36  ARG A NH1 1 
ATOM   254  N NH2 . ARG A 1 68  ? 22.514  -20.588 4.070   1.00 18.58 ? 36  ARG A NH2 1 
ATOM   255  N N   . PRO A 1 69  ? 13.078  -19.784 2.670   1.00 12.16 ? 37  PRO A N   1 
ATOM   256  C CA  . PRO A 1 69  ? 11.855  -19.032 2.316   1.00 13.70 ? 37  PRO A CA  1 
ATOM   257  C C   . PRO A 1 69  ? 11.518  -17.857 3.259   1.00 14.88 ? 37  PRO A C   1 
ATOM   258  O O   . PRO A 1 69  ? 10.924  -16.904 2.810   1.00 12.95 ? 37  PRO A O   1 
ATOM   259  C CB  . PRO A 1 69  ? 10.803  -20.116 2.457   1.00 14.00 ? 37  PRO A CB  1 
ATOM   260  C CG  . PRO A 1 69  ? 11.526  -21.371 2.006   1.00 12.04 ? 37  PRO A CG  1 
ATOM   261  C CD  . PRO A 1 69  ? 12.872  -21.253 2.681   1.00 12.57 ? 37  PRO A CD  1 
ATOM   262  N N   . TYR A 1 70  ? 11.853  -17.975 4.542   1.00 14.21 ? 38  TYR A N   1 
ATOM   263  C CA  . TYR A 1 70  ? 11.566  -16.982 5.596   1.00 15.46 ? 38  TYR A CA  1 
ATOM   264  C C   . TYR A 1 70  ? 12.613  -15.877 5.589   1.00 15.38 ? 38  TYR A C   1 
ATOM   265  O O   . TYR A 1 70  ? 12.271  -14.820 6.145   1.00 16.94 ? 38  TYR A O   1 
ATOM   266  C CB  . TYR A 1 70  ? 11.455  -17.674 6.954   1.00 16.17 ? 38  TYR A CB  1 
ATOM   267  C CG  . TYR A 1 70  ? 10.378  -18.720 6.938   1.00 15.90 ? 38  TYR A CG  1 
ATOM   268  C CD1 . TYR A 1 70  ? 9.031   -18.383 7.096   1.00 16.09 ? 38  TYR A CD1 1 
ATOM   269  C CD2 . TYR A 1 70  ? 10.705  -20.049 6.758   1.00 16.60 ? 38  TYR A CD2 1 
ATOM   270  C CE1 . TYR A 1 70  ? 8.041   -19.361 7.066   1.00 15.87 ? 38  TYR A CE1 1 
ATOM   271  C CE2 . TYR A 1 70  ? 9.743   -21.025 6.749   1.00 17.36 ? 38  TYR A CE2 1 
ATOM   272  C CZ  . TYR A 1 70  ? 8.415   -20.682 6.910   1.00 17.18 ? 38  TYR A CZ  1 
ATOM   273  O OH  . TYR A 1 70  ? 7.504   -21.688 6.852   1.00 17.41 ? 38  TYR A OH  1 
ATOM   274  N N   . GLU A 1 71  ? 13.749  -16.066 4.905   1.00 15.11 ? 39  GLU A N   1 
ATOM   275  C CA  . GLU A 1 71  ? 14.815  -15.023 4.735   1.00 16.37 ? 39  GLU A CA  1 
ATOM   276  C C   . GLU A 1 71  ? 14.701  -14.351 3.367   1.00 16.72 ? 39  GLU A C   1 
ATOM   277  O O   . GLU A 1 71  ? 15.314  -13.305 3.193   1.00 15.71 ? 39  GLU A O   1 
ATOM   278  C CB  . GLU A 1 71  ? 16.248  -15.560 4.862   1.00 20.90 ? 39  GLU A CB  1 
ATOM   279  C CG  . GLU A 1 71  ? 16.545  -16.237 6.201   1.00 26.21 ? 39  GLU A CG  1 
ATOM   280  C CD  . GLU A 1 71  ? 16.063  -15.505 7.437   1.00 31.67 ? 39  GLU A CD  1 
ATOM   281  O OE1 . GLU A 1 71  ? 16.141  -14.235 7.483   1.00 36.67 ? 39  GLU A OE1 1 
ATOM   282  O OE2 . GLU A 1 71  ? 15.581  -16.208 8.364   1.00 43.17 ? 39  GLU A OE2 1 
ATOM   283  N N   . GLY A 1 72  ? 13.892  -14.881 2.465   1.00 13.64 ? 40  GLY A N   1 
ATOM   284  C CA  . GLY A 1 72  ? 13.643  -14.262 1.163   1.00 14.31 ? 40  GLY A CA  1 
ATOM   285  C C   . GLY A 1 72  ? 14.743  -14.526 0.173   1.00 13.64 ? 40  GLY A C   1 
ATOM   286  O O   . GLY A 1 72  ? 14.867  -13.714 -0.799  1.00 13.47 ? 40  GLY A O   1 
ATOM   287  N N   . THR A 1 73  ? 15.521  -15.602 0.333   1.00 11.12 ? 41  THR A N   1 
ATOM   288  C CA  . THR A 1 73  ? 16.725  -15.784 -0.486  1.00 12.38 ? 41  THR A CA  1 
ATOM   289  C C   . THR A 1 73  ? 16.703  -17.139 -1.186  1.00 13.08 ? 41  THR A C   1 
ATOM   290  O O   . THR A 1 73  ? 16.214  -18.094 -0.607  1.00 12.22 ? 41  THR A O   1 
ATOM   291  C CB  . THR A 1 73  ? 17.983  -15.582 0.374   1.00 14.23 ? 41  THR A CB  1 
ATOM   292  O OG1 . THR A 1 73  ? 17.947  -16.473 1.488   1.00 12.92 ? 41  THR A OG1 1 
ATOM   293  C CG2 . THR A 1 73  ? 18.157  -14.169 0.894   1.00 13.21 ? 41  THR A CG2 1 
ATOM   294  N N   . GLN A 1 74  ? 17.202  -17.192 -2.434  1.00 11.90 ? 42  GLN A N   1 
ATOM   295  C CA  . GLN A 1 74  ? 17.240  -18.444 -3.220  1.00 12.28 ? 42  GLN A CA  1 
ATOM   296  C C   . GLN A 1 74  ? 18.295  -18.344 -4.328  1.00 12.89 ? 42  GLN A C   1 
ATOM   297  O O   . GLN A 1 74  ? 18.592  -17.227 -4.806  1.00 12.22 ? 42  GLN A O   1 
ATOM   298  C CB  . GLN A 1 74  ? 15.865  -18.767 -3.809  1.00 12.88 ? 42  GLN A CB  1 
ATOM   299  C CG  . GLN A 1 74  ? 15.369  -17.677 -4.747  1.00 14.21 ? 42  GLN A CG  1 
ATOM   300  C CD  . GLN A 1 74  ? 13.961  -17.990 -5.201  1.00 14.03 ? 42  GLN A CD  1 
ATOM   301  O OE1 . GLN A 1 74  ? 13.691  -19.094 -5.700  1.00 14.07 ? 42  GLN A OE1 1 
ATOM   302  N NE2 . GLN A 1 74  ? 13.070  -17.018 -4.986  1.00 14.29 ? 42  GLN A NE2 1 
ATOM   303  N N   . THR A 1 75  ? 18.822  -19.510 -4.696  1.00 12.60 ? 43  THR A N   1 
ATOM   304  C CA  . THR A 1 75  ? 19.672  -19.748 -5.869  1.00 12.13 ? 43  THR A CA  1 
ATOM   305  C C   . THR A 1 75  ? 19.155  -20.920 -6.695  1.00 13.35 ? 43  THR A C   1 
ATOM   306  O O   . THR A 1 75  ? 18.377  -21.720 -6.197  1.00 12.59 ? 43  THR A O   1 
ATOM   307  C CB  . THR A 1 75  ? 21.135  -20.001 -5.475  1.00 12.65 ? 43  THR A CB  1 
ATOM   308  O OG1 . THR A 1 75  ? 21.225  -21.216 -4.718  1.00 13.40 ? 43  THR A OG1 1 
ATOM   309  C CG2 . THR A 1 75  ? 21.684  -18.779 -4.784  1.00 12.65 ? 43  THR A CG2 1 
ATOM   310  N N   . ALA A 1 76  ? 19.499  -20.923 -7.972  1.00 13.47 ? 44  ALA A N   1 
ATOM   311  C CA  . ALA A 1 76  ? 19.112  -22.012 -8.857  1.00 14.83 ? 44  ALA A CA  1 
ATOM   312  C C   . ALA A 1 76  ? 20.145  -22.194 -9.945  1.00 14.22 ? 44  ALA A C   1 
ATOM   313  O O   . ALA A 1 76  ? 20.819  -21.232 -10.360 1.00 14.25 ? 44  ALA A O   1 
ATOM   314  C CB  . ALA A 1 76  ? 17.754  -21.771 -9.470  1.00 15.86 ? 44  ALA A CB  1 
ATOM   315  N N   . ARG A 1 77  ? 20.224  -23.442 -10.389 1.00 12.49 ? 45  ARG A N   1 
ATOM   316  C CA  . ARG A 1 77  ? 20.977  -23.873 -11.576 1.00 14.46 ? 45  ARG A CA  1 
ATOM   317  C C   . ARG A 1 77  ? 19.970  -24.208 -12.669 1.00 16.22 ? 45  ARG A C   1 
ATOM   318  O O   . ARG A 1 77  ? 19.194  -25.201 -12.467 1.00 15.16 ? 45  ARG A O   1 
ATOM   319  C CB  . ARG A 1 77  ? 21.802  -25.107 -11.171 1.00 14.83 ? 45  ARG A CB  1 
ATOM   320  C CG  . ARG A 1 77  ? 23.119  -24.797 -10.485 1.00 15.38 ? 45  ARG A CG  1 
ATOM   321  C CD  . ARG A 1 77  ? 22.951  -24.093 -9.178  1.00 16.62 ? 45  ARG A CD  1 
ATOM   322  N NE  . ARG A 1 77  ? 22.092  -24.831 -8.246  1.00 13.88 ? 45  ARG A NE  1 
ATOM   323  C CZ  . ARG A 1 77  ? 21.700  -24.328 -7.088  1.00 15.85 ? 45  ARG A CZ  1 
ATOM   324  N NH1 . ARG A 1 77  ? 22.123  -23.143 -6.676  1.00 15.36 ? 45  ARG A NH1 1 
ATOM   325  N NH2 . ARG A 1 77  ? 20.881  -24.990 -6.324  1.00 15.29 ? 45  ARG A NH2 1 
ATOM   326  N N   . LEU A 1 78  ? 20.064  -23.546 -13.828 1.00 14.89 ? 46  LEU A N   1 
ATOM   327  C CA  . LEU A 1 78  ? 19.140  -23.781 -14.949 1.00 15.88 ? 46  LEU A CA  1 
ATOM   328  C C   . LEU A 1 78  ? 19.934  -24.307 -16.149 1.00 17.12 ? 46  LEU A C   1 
ATOM   329  O O   . LEU A 1 78  ? 21.124  -23.948 -16.317 1.00 16.46 ? 46  LEU A O   1 
ATOM   330  C CB  . LEU A 1 78  ? 18.500  -22.446 -15.350 1.00 17.06 ? 46  LEU A CB  1 
ATOM   331  C CG  . LEU A 1 78  ? 17.575  -21.759 -14.343 1.00 16.74 ? 46  LEU A CG  1 
ATOM   332  C CD1 . LEU A 1 78  ? 16.643  -22.742 -13.650 1.00 17.13 ? 46  LEU A CD1 1 
ATOM   333  C CD2 . LEU A 1 78  ? 18.315  -20.915 -13.353 1.00 18.01 ? 46  LEU A CD2 1 
ATOM   334  N N   . LYS A 1 79  ? 19.272  -25.126 -16.948 1.00 17.49 ? 47  LYS A N   1 
ATOM   335  C CA  . LYS A 1 79  ? 19.817  -25.539 -18.247 1.00 20.05 ? 47  LYS A CA  1 
ATOM   336  C C   . LYS A 1 79  ? 18.687  -25.501 -19.267 1.00 18.13 ? 47  LYS A C   1 
ATOM   337  O O   . LYS A 1 79  ? 17.495  -25.848 -18.936 1.00 18.03 ? 47  LYS A O   1 
ATOM   338  C CB  . LYS A 1 79  ? 20.545  -26.888 -18.170 1.00 23.32 ? 47  LYS A CB  1 
ATOM   339  C CG  . LYS A 1 79  ? 19.760  -28.120 -17.806 1.00 30.68 ? 47  LYS A CG  1 
ATOM   340  C CD  . LYS A 1 79  ? 20.646  -29.242 -17.302 1.00 35.50 ? 47  LYS A CD  1 
ATOM   341  C CE  . LYS A 1 79  ? 19.821  -30.241 -16.529 1.00 38.94 ? 47  LYS A CE  1 
ATOM   342  N NZ  . LYS A 1 79  ? 20.350  -31.605 -16.731 1.00 45.00 ? 47  LYS A NZ  1 
ATOM   343  N N   . VAL A 1 80  ? 19.083  -25.200 -20.502 1.00 18.07 ? 48  VAL A N   1 
ATOM   344  C CA  . VAL A 1 80  ? 18.181  -25.283 -21.672 1.00 17.77 ? 48  VAL A CA  1 
ATOM   345  C C   . VAL A 1 80  ? 18.183  -26.739 -22.130 1.00 18.59 ? 48  VAL A C   1 
ATOM   346  O O   . VAL A 1 80  ? 19.254  -27.222 -22.476 1.00 22.50 ? 48  VAL A O   1 
ATOM   347  C CB  . VAL A 1 80  ? 18.619  -24.323 -22.781 1.00 19.93 ? 48  VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 80  ? 17.699  -24.486 -23.979 1.00 20.60 ? 48  VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 80  ? 18.672  -22.873 -22.303 1.00 18.33 ? 48  VAL A CG2 1 
ATOM   350  N N   . THR A 1 81  ? 17.071  -27.432 -22.054 1.00 19.00 ? 49  THR A N   1 
ATOM   351  C CA  . THR A 1 81  ? 16.969  -28.882 -22.384 1.00 19.30 ? 49  THR A CA  1 
ATOM   352  C C   . THR A 1 81  ? 16.415  -29.107 -23.807 1.00 21.77 ? 49  THR A C   1 
ATOM   353  O O   . THR A 1 81  ? 16.572  -30.209 -24.295 1.00 25.44 ? 49  THR A O   1 
ATOM   354  C CB  . THR A 1 81  ? 16.098  -29.589 -21.350 1.00 20.30 ? 49  THR A CB  1 
ATOM   355  O OG1 . THR A 1 81  ? 14.841  -28.904 -21.277 1.00 17.87 ? 49  THR A OG1 1 
ATOM   356  C CG2 . THR A 1 81  ? 16.785  -29.657 -19.998 1.00 22.53 ? 49  THR A CG2 1 
ATOM   357  N N   . LYS A 1 82  ? 15.724  -28.136 -24.421 1.00 21.58 ? 50  LYS A N   1 
ATOM   358  C CA  . LYS A 1 82  ? 15.224  -28.275 -25.818 1.00 22.61 ? 50  LYS A CA  1 
ATOM   359  C C   . LYS A 1 82  ? 15.374  -26.894 -26.457 1.00 20.72 ? 50  LYS A C   1 
ATOM   360  O O   . LYS A 1 82  ? 15.095  -25.884 -25.823 1.00 19.41 ? 50  LYS A O   1 
ATOM   361  C CB  . LYS A 1 82  ? 13.808  -28.877 -25.871 1.00 23.67 ? 50  LYS A CB  1 
ATOM   362  N N   . GLY A 1 83  ? 15.952  -26.837 -27.640 1.00 22.77 ? 51  GLY A N   1 
ATOM   363  C CA  . GLY A 1 83  ? 15.912  -25.629 -28.472 1.00 25.56 ? 51  GLY A CA  1 
ATOM   364  C C   . GLY A 1 83  ? 17.037  -24.677 -28.138 1.00 27.95 ? 51  GLY A C   1 
ATOM   365  O O   . GLY A 1 83  ? 16.984  -23.513 -28.562 1.00 24.15 ? 51  GLY A O   1 
ATOM   366  N N   . GLY A 1 84  ? 18.071  -25.145 -27.432 1.00 28.88 ? 52  GLY A N   1 
ATOM   367  C CA  . GLY A 1 84  ? 19.245  -24.294 -27.159 1.00 26.72 ? 52  GLY A CA  1 
ATOM   368  C C   . GLY A 1 84  ? 20.202  -24.316 -28.343 1.00 26.73 ? 52  GLY A C   1 
ATOM   369  O O   . GLY A 1 84  ? 20.250  -25.285 -29.104 1.00 28.80 ? 52  GLY A O   1 
ATOM   370  N N   . PRO A 1 85  ? 20.987  -23.265 -28.598 1.00 27.58 ? 53  PRO A N   1 
ATOM   371  C CA  . PRO A 1 85  ? 21.011  -22.038 -27.797 1.00 24.90 ? 53  PRO A CA  1 
ATOM   372  C C   . PRO A 1 85  ? 19.913  -21.050 -28.144 1.00 24.17 ? 53  PRO A C   1 
ATOM   373  O O   . PRO A 1 85  ? 19.507  -21.011 -29.239 1.00 24.03 ? 53  PRO A O   1 
ATOM   374  C CB  . PRO A 1 85  ? 22.351  -21.413 -28.215 1.00 27.40 ? 53  PRO A CB  1 
ATOM   375  C CG  . PRO A 1 85  ? 22.457  -21.793 -29.691 1.00 26.27 ? 53  PRO A CG  1 
ATOM   376  C CD  . PRO A 1 85  ? 21.941  -23.224 -29.734 1.00 27.80 ? 53  PRO A CD  1 
ATOM   377  N N   . LEU A 1 86  ? 19.491  -20.245 -27.184 1.00 24.23 ? 54  LEU A N   1 
ATOM   378  C CA  . LEU A 1 86  ? 18.376  -19.310 -27.401 1.00 25.14 ? 54  LEU A CA  1 
ATOM   379  C C   . LEU A 1 86  ? 18.916  -18.104 -28.157 1.00 25.63 ? 54  LEU A C   1 
ATOM   380  O O   . LEU A 1 86  ? 19.992  -17.600 -27.841 1.00 22.42 ? 54  LEU A O   1 
ATOM   381  C CB  . LEU A 1 86  ? 17.790  -18.872 -26.057 1.00 23.80 ? 54  LEU A CB  1 
ATOM   382  C CG  . LEU A 1 86  ? 17.403  -19.988 -25.100 1.00 23.22 ? 54  LEU A CG  1 
ATOM   383  C CD1 . LEU A 1 86  ? 16.999  -19.420 -23.759 1.00 22.96 ? 54  LEU A CD1 1 
ATOM   384  C CD2 . LEU A 1 86  ? 16.280  -20.824 -25.687 1.00 24.23 ? 54  LEU A CD2 1 
ATOM   385  N N   . PRO A 1 87  ? 18.167  -17.638 -29.179 1.00 24.52 ? 55  PRO A N   1 
ATOM   386  C CA  . PRO A 1 87  ? 18.503  -16.431 -29.942 1.00 23.50 ? 55  PRO A CA  1 
ATOM   387  C C   . PRO A 1 87  ? 18.087  -15.095 -29.309 1.00 24.92 ? 55  PRO A C   1 
ATOM   388  O O   . PRO A 1 87  ? 17.959  -14.085 -29.989 1.00 24.32 ? 55  PRO A O   1 
ATOM   389  C CB  . PRO A 1 87  ? 17.676  -16.598 -31.227 1.00 26.38 ? 55  PRO A CB  1 
ATOM   390  C CG  . PRO A 1 87  ? 16.464  -17.394 -30.769 1.00 24.51 ? 55  PRO A CG  1 
ATOM   391  C CD  . PRO A 1 87  ? 16.967  -18.327 -29.678 1.00 22.71 ? 55  PRO A CD  1 
ATOM   392  N N   . PHE A 1 88  ? 17.821  -15.100 -28.001 1.00 22.08 ? 56  PHE A N   1 
ATOM   393  C CA  . PHE A 1 88  ? 17.338  -13.904 -27.283 1.00 20.08 ? 56  PHE A CA  1 
ATOM   394  C C   . PHE A 1 88  ? 17.951  -13.906 -25.884 1.00 17.28 ? 56  PHE A C   1 
ATOM   395  O O   . PHE A 1 88  ? 18.479  -14.934 -25.436 1.00 19.14 ? 56  PHE A O   1 
ATOM   396  C CB  . PHE A 1 88  ? 15.804  -13.892 -27.267 1.00 19.11 ? 56  PHE A CB  1 
ATOM   397  C CG  . PHE A 1 88  ? 15.159  -15.089 -26.600 1.00 20.36 ? 56  PHE A CG  1 
ATOM   398  C CD1 . PHE A 1 88  ? 14.962  -15.096 -25.231 1.00 18.79 ? 56  PHE A CD1 1 
ATOM   399  C CD2 . PHE A 1 88  ? 14.740  -16.198 -27.332 1.00 18.19 ? 56  PHE A CD2 1 
ATOM   400  C CE1 . PHE A 1 88  ? 14.397  -16.202 -24.613 1.00 19.17 ? 56  PHE A CE1 1 
ATOM   401  C CE2 . PHE A 1 88  ? 14.185  -17.308 -26.708 1.00 18.62 ? 56  PHE A CE2 1 
ATOM   402  C CZ  . PHE A 1 88  ? 14.024  -17.292 -25.339 1.00 17.87 ? 56  PHE A CZ  1 
ATOM   403  N N   . ALA A 1 89  ? 17.813  -12.769 -25.231 1.00 18.20 ? 57  ALA A N   1 
ATOM   404  C CA  . ALA A 1 89  ? 18.400  -12.419 -23.927 1.00 17.58 ? 57  ALA A CA  1 
ATOM   405  C C   . ALA A 1 89  ? 17.812  -13.334 -22.857 1.00 16.25 ? 57  ALA A C   1 
ATOM   406  O O   . ALA A 1 89  ? 16.586  -13.404 -22.741 1.00 16.49 ? 57  ALA A O   1 
ATOM   407  C CB  . ALA A 1 89  ? 18.146  -10.989 -23.612 1.00 16.65 ? 57  ALA A CB  1 
ATOM   408  N N   . TRP A 1 90  ? 18.675  -14.033 -22.125 1.00 14.14 ? 58  TRP A N   1 
ATOM   409  C CA  . TRP A 1 90  ? 18.250  -14.810 -20.953 1.00 14.59 ? 58  TRP A CA  1 
ATOM   410  C C   . TRP A 1 90  ? 17.417  -13.915 -20.016 1.00 14.30 ? 58  TRP A C   1 
ATOM   411  O O   . TRP A 1 90  ? 16.488  -14.446 -19.360 1.00 15.72 ? 58  TRP A O   1 
ATOM   412  C CB  . TRP A 1 90  ? 19.463  -15.391 -20.252 1.00 14.78 ? 58  TRP A CB  1 
ATOM   413  C CG  . TRP A 1 90  ? 19.091  -16.195 -19.055 1.00 15.82 ? 58  TRP A CG  1 
ATOM   414  C CD1 . TRP A 1 90  ? 18.996  -15.742 -17.766 1.00 17.44 ? 58  TRP A CD1 1 
ATOM   415  C CD2 . TRP A 1 90  ? 18.664  -17.555 -19.020 1.00 16.65 ? 58  TRP A CD2 1 
ATOM   416  N NE1 . TRP A 1 90  ? 18.565  -16.745 -16.945 1.00 16.27 ? 58  TRP A NE1 1 
ATOM   417  C CE2 . TRP A 1 90  ? 18.377  -17.866 -17.673 1.00 16.99 ? 58  TRP A CE2 1 
ATOM   418  C CE3 . TRP A 1 90  ? 18.554  -18.550 -19.974 1.00 17.11 ? 58  TRP A CE3 1 
ATOM   419  C CZ2 . TRP A 1 90  ? 17.973  -19.125 -17.259 1.00 19.56 ? 58  TRP A CZ2 1 
ATOM   420  C CZ3 . TRP A 1 90  ? 18.123  -19.787 -19.571 1.00 18.49 ? 58  TRP A CZ3 1 
ATOM   421  C CH2 . TRP A 1 90  ? 17.860  -20.076 -18.238 1.00 19.94 ? 58  TRP A CH2 1 
ATOM   422  N N   . ASP A 1 91  ? 17.746  -12.623 -19.921 1.00 15.07 ? 59  ASP A N   1 
ATOM   423  C CA  . ASP A 1 91  ? 17.165  -11.667 -18.947 1.00 14.21 ? 59  ASP A CA  1 
ATOM   424  C C   . ASP A 1 91  ? 15.628  -11.654 -19.013 1.00 14.44 ? 59  ASP A C   1 
ATOM   425  O O   . ASP A 1 91  ? 15.024  -11.339 -18.002 1.00 15.64 ? 59  ASP A O   1 
ATOM   426  C CB  . ASP A 1 91  ? 17.776  -10.264 -19.067 1.00 14.98 ? 59  ASP A CB  1 
ATOM   427  C CG  . ASP A 1 91  ? 19.206  -10.114 -18.564 1.00 19.08 ? 59  ASP A CG  1 
ATOM   428  O OD1 . ASP A 1 91  ? 19.639  -10.935 -17.696 1.00 18.25 ? 59  ASP A OD1 1 
ATOM   429  O OD2 . ASP A 1 91  ? 19.905  -9.165  -19.022 1.00 19.65 ? 59  ASP A OD2 1 
ATOM   430  N N   . ILE A 1 92  ? 15.008  -11.913 -20.164 1.00 14.02 ? 60  ILE A N   1 
ATOM   431  C CA  . ILE A 1 92  ? 13.531  -11.824 -20.217 1.00 14.51 ? 60  ILE A CA  1 
ATOM   432  C C   . ILE A 1 92  ? 12.956  -13.082 -19.554 1.00 15.72 ? 60  ILE A C   1 
ATOM   433  O O   . ILE A 1 92  ? 11.788  -13.013 -19.191 1.00 15.83 ? 60  ILE A O   1 
ATOM   434  C CB  . ILE A 1 92  ? 12.970  -11.568 -21.640 1.00 16.00 ? 60  ILE A CB  1 
ATOM   435  C CG1 . ILE A 1 92  ? 13.168  -12.767 -22.546 1.00 15.72 ? 60  ILE A CG1 1 
ATOM   436  C CG2 . ILE A 1 92  ? 13.543  -10.276 -22.203 1.00 17.24 ? 60  ILE A CG2 1 
ATOM   437  C CD1 . ILE A 1 92  ? 12.352  -12.660 -23.835 1.00 17.72 ? 60  ILE A CD1 1 
ATOM   438  N N   . LEU A 1 93  ? 13.712  -14.175 -19.389 1.00 14.21 ? 61  LEU A N   1 
ATOM   439  C CA  . LEU A 1 93  ? 13.201  -15.418 -18.750 1.00 15.39 ? 61  LEU A CA  1 
ATOM   440  C C   . LEU A 1 93  ? 13.469  -15.403 -17.254 1.00 15.29 ? 61  LEU A C   1 
ATOM   441  O O   . LEU A 1 93  ? 12.754  -16.071 -16.479 1.00 14.15 ? 61  LEU A O   1 
ATOM   442  C CB  . LEU A 1 93  ? 13.857  -16.629 -19.399 1.00 17.35 ? 61  LEU A CB  1 
ATOM   443  C CG  . LEU A 1 93  ? 13.708  -16.714 -20.920 1.00 18.04 ? 61  LEU A CG  1 
ATOM   444  C CD1 . LEU A 1 93  ? 14.328  -17.995 -21.410 1.00 18.43 ? 61  LEU A CD1 1 
ATOM   445  C CD2 . LEU A 1 93  ? 12.235  -16.642 -21.352 1.00 20.08 ? 61  LEU A CD2 1 
ATOM   446  N N   . SER A 1 94  ? 14.496  -14.705 -16.826 1.00 14.39 ? 62  SER A N   1 
ATOM   447  C CA  . SER A 1 94  ? 14.972  -14.885 -15.419 1.00 14.74 ? 62  SER A CA  1 
ATOM   448  C C   . SER A 1 94  ? 13.891  -14.527 -14.398 1.00 13.33 ? 62  SER A C   1 
ATOM   449  O O   . SER A 1 94  ? 13.775  -15.211 -13.374 1.00 12.94 ? 62  SER A O   1 
ATOM   450  C CB  . SER A 1 94  ? 16.250  -14.163 -15.180 1.00 12.96 ? 62  SER A CB  1 
ATOM   451  O OG  . SER A 1 94  ? 16.114  -12.775 -15.361 1.00 14.15 ? 62  SER A OG  1 
ATOM   452  N N   . PRO A 1 95  ? 13.039  -13.502 -14.589 1.00 13.69 ? 63  PRO A N   1 
ATOM   453  C CA  . PRO A 1 95  ? 11.965  -13.229 -13.637 1.00 13.30 ? 63  PRO A CA  1 
ATOM   454  C C   . PRO A 1 95  ? 10.819  -14.244 -13.697 1.00 12.52 ? 63  PRO A C   1 
ATOM   455  O O   . PRO A 1 95  ? 9.999   -14.232 -12.824 1.00 12.48 ? 63  PRO A O   1 
ATOM   456  C CB  . PRO A 1 95  ? 11.456  -11.864 -14.044 1.00 13.13 ? 63  PRO A CB  1 
ATOM   457  C CG  . PRO A 1 95  ? 12.575  -11.325 -14.896 1.00 13.22 ? 63  PRO A CG  1 
ATOM   458  C CD  . PRO A 1 95  ? 13.006  -12.540 -15.682 1.00 13.96 ? 63  PRO A CD  1 
ATOM   459  N N   . GLN A 1 96  ? 10.773  -15.084 -14.730 1.00 13.08 ? 64  GLN A N   1 
ATOM   460  C CA  . GLN A 1 96  ? 9.742   -16.162 -14.826 1.00 13.94 ? 64  GLN A CA  1 
ATOM   461  C C   . GLN A 1 96  ? 10.264  -17.409 -14.102 1.00 14.98 ? 64  GLN A C   1 
ATOM   462  O O   . GLN A 1 96  ? 9.472   -18.208 -13.627 1.00 14.64 ? 64  GLN A O   1 
ATOM   463  C CB  . GLN A 1 96  ? 9.312   -16.445 -16.259 1.00 13.83 ? 64  GLN A CB  1 
ATOM   464  C CG  . GLN A 1 96  ? 9.395   -15.256 -17.166 1.00 13.26 ? 64  GLN A CG  1 
ATOM   465  C CD  . GLN A 1 96  ? 8.872   -13.930 -16.694 1.00 14.51 ? 64  GLN A CD  1 
ATOM   466  O OE1 . GLN A 1 96  ? 7.973   -13.800 -15.823 1.00 14.89 ? 64  GLN A OE1 1 
ATOM   467  N NE2 . GLN A 1 96  ? 9.479   -12.902 -17.266 1.00 14.60 ? 64  GLN A NE2 1 
ATOM   468  N N   . ILE A 1 97  ? 11.566  -17.501 -13.924 1.00 16.09 ? 65  ILE A N   1 
ATOM   469  C CA  . ILE A 1 97  ? 12.198  -18.601 -13.160 1.00 17.80 ? 65  ILE A CA  1 
ATOM   470  C C   . ILE A 1 97  ? 12.018  -18.348 -11.673 1.00 17.20 ? 65  ILE A C   1 
ATOM   471  O O   . ILE A 1 97  ? 11.781  -19.212 -10.902 1.00 20.59 ? 65  ILE A O   1 
ATOM   472  C CB  . ILE A 1 97  ? 13.664  -18.691 -13.604 1.00 20.16 ? 65  ILE A CB  1 
ATOM   473  C CG1 . ILE A 1 97  ? 13.667  -19.069 -15.084 1.00 23.57 ? 65  ILE A CG1 1 
ATOM   474  C CG2 . ILE A 1 97  ? 14.429  -19.672 -12.765 1.00 21.89 ? 65  ILE A CG2 1 
ATOM   475  C CD1 . ILE A 1 97  ? 14.963  -18.875 -15.731 1.00 27.57 ? 65  ILE A CD1 1 
HETATM 476  N N1  . CH6 A 1 101 ? 12.085  -17.079 -11.466 1.00 20.29 ? 68  CH6 A N1  1 
HETATM 477  C CE  . CH6 A 1 101 ? 16.462  -18.573 -8.556  1.00 17.92 ? 68  CH6 A CE  1 
HETATM 478  S SD  . CH6 A 1 101 ? 15.875  -16.937 -8.705  1.00 15.19 ? 68  CH6 A SD  1 
HETATM 479  C CG1 . CH6 A 1 101 ? 14.163  -17.284 -9.041  1.00 17.46 ? 68  CH6 A CG1 1 
HETATM 480  C CB1 . CH6 A 1 101 ? 13.399  -16.222 -9.704  1.00 18.11 ? 68  CH6 A CB1 1 
HETATM 481  C CA1 . CH6 A 1 101 ? 11.954  -16.559 -10.185 1.00 18.64 ? 68  CH6 A CA1 1 
HETATM 482  C C1  . CH6 A 1 101 ? 11.139  -15.296 -10.143 1.00 16.73 ? 68  CH6 A C1  1 
HETATM 483  N N2  . CH6 A 1 101 ? 11.547  -13.928 -9.948  1.00 15.88 ? 68  CH6 A N2  1 
HETATM 484  O OH  . CH6 A 1 101 ? 13.546  -7.403  -10.648 1.00 19.97 ? 68  CH6 A OH  1 
HETATM 485  C CD2 . CH6 A 1 101 ? 10.617  -9.516  -10.017 1.00 17.05 ? 68  CH6 A CD2 1 
HETATM 486  C CE2 . CH6 A 1 101 ? 11.425  -8.409  -10.204 1.00 19.15 ? 68  CH6 A CE2 1 
HETATM 487  C CZ  . CH6 A 1 101 ? 12.777  -8.553  -10.523 1.00 19.81 ? 68  CH6 A CZ  1 
HETATM 488  C CE1 . CH6 A 1 101 ? 13.303  -9.843  -10.660 1.00 19.73 ? 68  CH6 A CE1 1 
HETATM 489  C CD1 . CH6 A 1 101 ? 12.491  -10.980 -10.471 1.00 17.09 ? 68  CH6 A CD1 1 
HETATM 490  C CG2 . CH6 A 1 101 ? 11.132  -10.769 -10.151 1.00 17.24 ? 68  CH6 A CG2 1 
HETATM 491  C CB2 . CH6 A 1 101 ? 10.147  -11.810 -9.853  1.00 15.45 ? 68  CH6 A CB2 1 
HETATM 492  C CA2 . CH6 A 1 101 ? 10.388  -13.237 -9.895  1.00 15.46 ? 68  CH6 A CA2 1 
HETATM 493  C C2  . CH6 A 1 101 ? 9.302   -14.141 -9.987  1.00 13.74 ? 68  CH6 A C2  1 
HETATM 494  O O2  . CH6 A 1 101 ? 8.028   -13.810 -10.003 1.00 14.30 ? 68  CH6 A O2  1 
HETATM 495  N N3  . CH6 A 1 101 ? 9.777   -15.398 -10.139 1.00 15.00 ? 68  CH6 A N3  1 
HETATM 496  C CA3 . CH6 A 1 101 ? 8.972   -16.575 -10.453 1.00 13.78 ? 68  CH6 A CA3 1 
HETATM 497  C C3  . CH6 A 1 101 ? 8.796   -17.551 -9.372  1.00 14.27 ? 68  CH6 A C3  1 
HETATM 498  O O3  . CH6 A 1 101 ? 8.329   -18.691 -9.531  1.00 15.61 ? 68  CH6 A O3  1 
ATOM   499  N N   . SER A 1 102 ? 9.247   -17.236 -8.005  1.00 12.75 ? 69  SER A N   1 
ATOM   500  C CA  . SER A 1 102 ? 9.484   -18.240 -6.967  1.00 13.11 ? 69  SER A CA  1 
ATOM   501  C C   . SER A 1 102 ? 9.106   -17.511 -5.681  1.00 12.59 ? 69  SER A C   1 
ATOM   502  O O   . SER A 1 102 ? 9.944   -17.368 -4.823  1.00 12.95 ? 69  SER A O   1 
ATOM   503  C CB  . SER A 1 102 ? 10.924  -18.698 -7.030  1.00 12.18 ? 69  SER A CB  1 
ATOM   504  O OG  . SER A 1 102 ? 11.168  -19.726 -6.096  1.00 14.40 ? 69  SER A OG  1 
ATOM   505  N N   . LYS A 1 103 ? 7.870   -17.030 -5.602  1.00 14.06 ? 70  LYS A N   1 
ATOM   506  C CA  . LYS A 1 103 ? 7.412   -16.081 -4.566  1.00 16.14 ? 70  LYS A CA  1 
ATOM   507  C C   . LYS A 1 103 ? 7.117   -16.750 -3.226  1.00 14.68 ? 70  LYS A C   1 
ATOM   508  O O   . LYS A 1 103 ? 6.830   -15.985 -2.273  1.00 14.21 ? 70  LYS A O   1 
ATOM   509  C CB  . LYS A 1 103 ? 6.138   -15.383 -5.025  1.00 19.08 ? 70  LYS A CB  1 
ATOM   510  C CG  . LYS A 1 103 ? 6.386   -14.511 -6.232  1.00 20.60 ? 70  LYS A CG  1 
ATOM   511  C CD  . LYS A 1 103 ? 7.187   -13.345 -5.924  1.00 21.94 ? 70  LYS A CD  1 
ATOM   512  C CE  . LYS A 1 103 ? 6.731   -12.180 -6.765  1.00 26.66 ? 70  LYS A CE  1 
ATOM   513  N NZ  . LYS A 1 103 ? 7.444   -10.993 -6.314  1.00 28.59 ? 70  LYS A NZ  1 
ATOM   514  N N   . ALA A 1 104 ? 7.282   -18.081 -3.076  1.00 12.84 ? 71  ALA A N   1 
ATOM   515  C CA  . ALA A 1 104 ? 7.355   -18.651 -1.714  1.00 12.72 ? 71  ALA A CA  1 
ATOM   516  C C   . ALA A 1 104 ? 8.608   -18.169 -0.982  1.00 13.13 ? 71  ALA A C   1 
ATOM   517  O O   . ALA A 1 104 ? 8.619   -18.237 0.263   1.00 11.85 ? 71  ALA A O   1 
ATOM   518  C CB  . ALA A 1 104 ? 7.335   -20.157 -1.783  1.00 14.17 ? 71  ALA A CB  1 
ATOM   519  N N   . TYR A 1 105 ? 9.617   -17.628 -1.682  1.00 12.13 ? 72  TYR A N   1 
ATOM   520  C CA  . TYR A 1 105 ? 10.877  -17.166 -1.050  1.00 12.93 ? 72  TYR A CA  1 
ATOM   521  C C   . TYR A 1 105 ? 10.893  -15.637 -0.955  1.00 12.64 ? 72  TYR A C   1 
ATOM   522  O O   . TYR A 1 105 ? 11.729  -14.974 -1.683  1.00 13.33 ? 72  TYR A O   1 
ATOM   523  C CB  . TYR A 1 105 ? 12.108  -17.728 -1.739  1.00 12.25 ? 72  TYR A CB  1 
ATOM   524  C CG  . TYR A 1 105 ? 12.245  -19.216 -1.867  1.00 11.80 ? 72  TYR A CG  1 
ATOM   525  C CD1 . TYR A 1 105 ? 11.626  -19.919 -2.900  1.00 12.57 ? 72  TYR A CD1 1 
ATOM   526  C CD2 . TYR A 1 105 ? 13.134  -19.916 -1.066  1.00 10.22 ? 72  TYR A CD2 1 
ATOM   527  C CE1 . TYR A 1 105 ? 11.834  -21.287 -3.069  1.00 11.39 ? 72  TYR A CE1 1 
ATOM   528  C CE2 . TYR A 1 105 ? 13.351  -21.278 -1.236  1.00 10.98 ? 72  TYR A CE2 1 
ATOM   529  C CZ  . TYR A 1 105 ? 12.683  -21.970 -2.213  1.00 11.90 ? 72  TYR A CZ  1 
ATOM   530  O OH  . TYR A 1 105 ? 12.930  -23.309 -2.415  1.00 12.21 ? 72  TYR A OH  1 
ATOM   531  N N   . VAL A 1 106 ? 9.990   -15.104 -0.106  1.00 13.52 ? 73  VAL A N   1 
ATOM   532  C CA  . VAL A 1 106 ? 9.862   -13.640 0.145   1.00 12.64 ? 73  VAL A CA  1 
ATOM   533  C C   . VAL A 1 106 ? 9.765   -13.468 1.655   1.00 12.94 ? 73  VAL A C   1 
ATOM   534  O O   . VAL A 1 106 ? 8.866   -14.037 2.269   1.00 13.10 ? 73  VAL A O   1 
ATOM   535  C CB  . VAL A 1 106 ? 8.668   -12.966 -0.556  1.00 11.90 ? 73  VAL A CB  1 
ATOM   536  C CG1 . VAL A 1 106 ? 8.635   -11.484 -0.223  1.00 11.27 ? 73  VAL A CG1 1 
ATOM   537  C CG2 . VAL A 1 106 ? 8.646   -13.098 -2.032  1.00 12.07 ? 73  VAL A CG2 1 
ATOM   538  N N   . LYS A 1 107 ? 10.705  -12.736 2.250   1.00 13.94 ? 74  LYS A N   1 
ATOM   539  C CA  . LYS A 1 107 ? 10.660  -12.494 3.708   1.00 14.69 ? 74  LYS A CA  1 
ATOM   540  C C   . LYS A 1 107 ? 9.481   -11.562 3.999   1.00 15.66 ? 74  LYS A C   1 
ATOM   541  O O   . LYS A 1 107 ? 9.367   -10.497 3.361   1.00 14.78 ? 74  LYS A O   1 
ATOM   542  C CB  . LYS A 1 107 ? 11.953  -11.863 4.185   1.00 17.22 ? 74  LYS A CB  1 
ATOM   543  C CG  . LYS A 1 107 ? 11.959  -11.476 5.637   1.00 18.90 ? 74  LYS A CG  1 
ATOM   544  C CD  . LYS A 1 107 ? 13.378  -11.098 6.045   1.00 21.69 ? 74  LYS A CD  1 
ATOM   545  C CE  . LYS A 1 107 ? 13.363  -10.528 7.446   1.00 27.69 ? 74  LYS A CE  1 
ATOM   546  N NZ  . LYS A 1 107 ? 14.740  -10.204 7.870   1.00 32.88 ? 74  LYS A NZ  1 
ATOM   547  N N   . HIS A 1 108 ? 8.559   -11.988 4.867   1.00 13.59 ? 75  HIS A N   1 
ATOM   548  C CA  . HIS A 1 108 ? 7.398   -11.145 5.247   1.00 13.44 ? 75  HIS A CA  1 
ATOM   549  C C   . HIS A 1 108 ? 7.450   -10.848 6.736   1.00 14.79 ? 75  HIS A C   1 
ATOM   550  O O   . HIS A 1 108 ? 7.638   -11.741 7.527   1.00 16.01 ? 75  HIS A O   1 
ATOM   551  C CB  . HIS A 1 108 ? 6.049   -11.793 4.877   1.00 12.56 ? 75  HIS A CB  1 
ATOM   552  C CG  . HIS A 1 108 ? 5.680   -11.705 3.433   1.00 12.14 ? 75  HIS A CG  1 
ATOM   553  N ND1 . HIS A 1 108 ? 6.295   -12.514 2.460   1.00 12.37 ? 75  HIS A ND1 1 
ATOM   554  C CD2 . HIS A 1 108 ? 4.712   -11.003 2.804   1.00 12.45 ? 75  HIS A CD2 1 
ATOM   555  C CE1 . HIS A 1 108 ? 5.734   -12.254 1.281   1.00 12.16 ? 75  HIS A CE1 1 
ATOM   556  N NE2 . HIS A 1 108 ? 4.790   -11.261 1.445   1.00 13.15 ? 75  HIS A NE2 1 
ATOM   557  N N   . PRO A 1 109 ? 7.123   -9.621  7.155   1.00 17.05 ? 76  PRO A N   1 
ATOM   558  C CA  . PRO A 1 109 ? 6.871   -9.368  8.574   1.00 16.35 ? 76  PRO A CA  1 
ATOM   559  C C   . PRO A 1 109 ? 5.607   -10.111 9.022   1.00 16.40 ? 76  PRO A C   1 
ATOM   560  O O   . PRO A 1 109 ? 4.755   -10.453 8.200   1.00 14.65 ? 76  PRO A O   1 
ATOM   561  C CB  . PRO A 1 109 ? 6.812   -7.842  8.628   1.00 18.10 ? 76  PRO A CB  1 
ATOM   562  C CG  . PRO A 1 109 ? 6.321   -7.425  7.276   1.00 19.01 ? 76  PRO A CG  1 
ATOM   563  C CD  . PRO A 1 109 ? 6.871   -8.448  6.296   1.00 17.80 ? 76  PRO A CD  1 
ATOM   564  N N   . ALA A 1 110 ? 5.528   -10.417 10.314  1.00 17.03 ? 77  ALA A N   1 
ATOM   565  C CA  . ALA A 1 110 ? 4.396   -11.113 10.953  1.00 19.06 ? 77  ALA A CA  1 
ATOM   566  C C   . ALA A 1 110 ? 3.067   -10.412 10.680  1.00 17.01 ? 77  ALA A C   1 
ATOM   567  O O   . ALA A 1 110 ? 2.043   -11.085 10.708  1.00 21.41 ? 77  ALA A O   1 
ATOM   568  C CB  . ALA A 1 110 ? 4.631   -11.228 12.424  1.00 20.86 ? 77  ALA A CB  1 
ATOM   569  N N   . ASP A 1 111 ? 3.056   -9.119  10.448  1.00 17.63 ? 78  ASP A N   1 
ATOM   570  C CA  . ASP A 1 111 ? 1.792   -8.334  10.376  1.00 18.16 ? 78  ASP A CA  1 
ATOM   571  C C   . ASP A 1 111 ? 1.381   -8.165  8.908   1.00 16.27 ? 78  ASP A C   1 
ATOM   572  O O   . ASP A 1 111 ? 0.436   -7.434  8.668   1.00 18.71 ? 78  ASP A O   1 
ATOM   573  C CB  . ASP A 1 111 ? 1.894   -6.977  11.082  1.00 19.69 ? 78  ASP A CB  1 
ATOM   574  C CG  . ASP A 1 111 ? 2.908   -6.035  10.469  1.00 18.94 ? 78  ASP A CG  1 
ATOM   575  O OD1 . ASP A 1 111 ? 3.842   -6.500  9.864   1.00 21.48 ? 78  ASP A OD1 1 
ATOM   576  O OD2 . ASP A 1 111 ? 2.735   -4.827  10.613  1.00 26.89 ? 78  ASP A OD2 1 
ATOM   577  N N   . ILE A 1 112 ? 2.026   -8.859  7.971   1.00 14.02 ? 79  ILE A N   1 
ATOM   578  C CA  . ILE A 1 112 ? 1.537   -8.897  6.549   1.00 13.71 ? 79  ILE A CA  1 
ATOM   579  C C   . ILE A 1 112 ? 1.320   -10.358 6.218   1.00 12.50 ? 79  ILE A C   1 
ATOM   580  O O   . ILE A 1 112 ? 2.287   -11.132 6.246   1.00 14.07 ? 79  ILE A O   1 
ATOM   581  C CB  . ILE A 1 112 ? 2.492   -8.262  5.550   1.00 13.64 ? 79  ILE A CB  1 
ATOM   582  C CG1 . ILE A 1 112 ? 2.800   -6.792  5.894   1.00 14.03 ? 79  ILE A CG1 1 
ATOM   583  C CG2 . ILE A 1 112 ? 1.900   -8.403  4.135   1.00 13.77 ? 79  ILE A CG2 1 
ATOM   584  C CD1 . ILE A 1 112 ? 3.758   -6.124  4.915   1.00 14.75 ? 79  ILE A CD1 1 
ATOM   585  N N   . PRO A 1 113 ? 0.059   -10.780 6.010   1.00 13.13 ? 80  PRO A N   1 
ATOM   586  C CA  . PRO A 1 113 ? -0.231  -12.170 5.675   1.00 12.56 ? 80  PRO A CA  1 
ATOM   587  C C   . PRO A 1 113 ? 0.624   -12.596 4.480   1.00 13.33 ? 80  PRO A C   1 
ATOM   588  O O   . PRO A 1 113 ? 0.575   -11.905 3.458   1.00 13.76 ? 80  PRO A O   1 
ATOM   589  C CB  . PRO A 1 113 ? -1.745  -12.127 5.359   1.00 13.97 ? 80  PRO A CB  1 
ATOM   590  C CG  . PRO A 1 113 ? -2.236  -10.988 6.230   1.00 13.37 ? 80  PRO A CG  1 
ATOM   591  C CD  . PRO A 1 113 ? -1.134  -9.962  6.129   1.00 12.87 ? 80  PRO A CD  1 
ATOM   592  N N   . ASP A 1 114 ? 1.311   -13.740 4.594   1.00 12.32 ? 81  ASP A N   1 
ATOM   593  C CA  . ASP A 1 114 ? 2.192   -14.304 3.542   1.00 12.55 ? 81  ASP A CA  1 
ATOM   594  C C   . ASP A 1 114 ? 1.341   -15.289 2.736   1.00 10.85 ? 81  ASP A C   1 
ATOM   595  O O   . ASP A 1 114 ? 1.511   -16.536 2.796   1.00 11.23 ? 81  ASP A O   1 
ATOM   596  C CB  . ASP A 1 114 ? 3.446   -14.910 4.160   1.00 13.29 ? 81  ASP A CB  1 
ATOM   597  C CG  . ASP A 1 114 ? 4.548   -15.183 3.148   1.00 12.43 ? 81  ASP A CG  1 
ATOM   598  O OD1 . ASP A 1 114 ? 4.265   -15.246 1.924   1.00 13.26 ? 81  ASP A OD1 1 
ATOM   599  O OD2 . ASP A 1 114 ? 5.719   -15.299 3.609   1.00 13.37 ? 81  ASP A OD2 1 
ATOM   600  N N   . TYR A 1 115 ? 0.421   -14.697 1.987   1.00 11.47 ? 82  TYR A N   1 
ATOM   601  C CA  . TYR A 1 115 ? -0.615  -15.383 1.189   1.00 10.99 ? 82  TYR A CA  1 
ATOM   602  C C   . TYR A 1 115 ? -0.005  -16.552 0.403   1.00 12.02 ? 82  TYR A C   1 
ATOM   603  O O   . TYR A 1 115 ? -0.573  -17.669 0.427   1.00 12.91 ? 82  TYR A O   1 
ATOM   604  C CB  . TYR A 1 115 ? -1.271  -14.363 0.260   1.00 12.30 ? 82  TYR A CB  1 
ATOM   605  C CG  . TYR A 1 115 ? -2.282  -14.869 -0.725  1.00 11.75 ? 82  TYR A CG  1 
ATOM   606  C CD1 . TYR A 1 115 ? -3.574  -15.234 -0.345  1.00 12.29 ? 82  TYR A CD1 1 
ATOM   607  C CD2 . TYR A 1 115 ? -1.982  -14.844 -2.079  1.00 12.10 ? 82  TYR A CD2 1 
ATOM   608  C CE1 . TYR A 1 115 ? -4.533  -15.535 -1.293  1.00 11.83 ? 82  TYR A CE1 1 
ATOM   609  C CE2 . TYR A 1 115 ? -2.925  -15.177 -3.041  1.00 12.29 ? 82  TYR A CE2 1 
ATOM   610  C CZ  . TYR A 1 115 ? -4.212  -15.491 -2.645  1.00 13.88 ? 82  TYR A CZ  1 
ATOM   611  O OH  . TYR A 1 115 ? -5.150  -15.907 -3.565  1.00 13.01 ? 82  TYR A OH  1 
ATOM   612  N N   . LEU A 1 116 ? 1.143   -16.351 -0.239  1.00 12.22 ? 83  LEU A N   1 
ATOM   613  C CA  . LEU A 1 116 ? 1.679   -17.390 -1.137  1.00 12.57 ? 83  LEU A CA  1 
ATOM   614  C C   . LEU A 1 116 ? 2.291   -18.512 -0.318  1.00 11.50 ? 83  LEU A C   1 
ATOM   615  O O   . LEU A 1 116 ? 2.132   -19.735 -0.755  1.00 12.16 ? 83  LEU A O   1 
ATOM   616  C CB  . LEU A 1 116 ? 2.610   -16.744 -2.180  1.00 13.51 ? 83  LEU A CB  1 
ATOM   617  C CG  . LEU A 1 116 ? 1.871   -15.764 -3.100  1.00 13.63 ? 83  LEU A CG  1 
ATOM   618  C CD1 . LEU A 1 116 ? 2.779   -15.181 -4.177  1.00 15.00 ? 83  LEU A CD1 1 
ATOM   619  C CD2 . LEU A 1 116 ? 0.662   -16.392 -3.788  1.00 12.98 ? 83  LEU A CD2 1 
ATOM   620  N N   . LYS A 1 117 ? 2.948   -18.234 0.819   1.00 10.86 ? 84  LYS A N   1 
ATOM   621  C CA  . LYS A 1 117 ? 3.385   -19.332 1.716   1.00 12.37 ? 84  LYS A CA  1 
ATOM   622  C C   . LYS A 1 117 ? 2.178   -20.070 2.317   1.00 13.76 ? 84  LYS A C   1 
ATOM   623  O O   . LYS A 1 117 ? 2.164   -21.350 2.302   1.00 12.75 ? 84  LYS A O   1 
ATOM   624  C CB  . LYS A 1 117 ? 4.264   -18.865 2.854   1.00 12.49 ? 84  LYS A CB  1 
ATOM   625  C CG  . LYS A 1 117 ? 5.722   -18.671 2.474   1.00 13.08 ? 84  LYS A CG  1 
ATOM   626  C CD  . LYS A 1 117 ? 6.515   -18.439 3.693   1.00 12.09 ? 84  LYS A CD  1 
ATOM   627  C CE  . LYS A 1 117 ? 7.922   -18.002 3.386   1.00 12.27 ? 84  LYS A CE  1 
ATOM   628  N NZ  . LYS A 1 117 ? 7.983   -16.617 2.813   1.00 11.99 ? 84  LYS A NZ  1 
ATOM   629  N N   . LEU A 1 118 ? 1.170   -19.313 2.742   1.00 13.32 ? 85  LEU A N   1 
ATOM   630  C CA  . LEU A 1 118 ? -0.071  -19.903 3.296   1.00 14.44 ? 85  LEU A CA  1 
ATOM   631  C C   . LEU A 1 118 ? -0.716  -20.881 2.313   1.00 14.01 ? 85  LEU A C   1 
ATOM   632  O O   . LEU A 1 118 ? -1.400  -21.844 2.794   1.00 14.87 ? 85  LEU A O   1 
ATOM   633  C CB  . LEU A 1 118 ? -1.016  -18.772 3.678   1.00 13.73 ? 85  LEU A CB  1 
ATOM   634  C CG  . LEU A 1 118 ? -0.567  -17.913 4.848   1.00 16.24 ? 85  LEU A CG  1 
ATOM   635  C CD1 . LEU A 1 118 ? -1.349  -16.607 4.819   1.00 15.87 ? 85  LEU A CD1 1 
ATOM   636  C CD2 . LEU A 1 118 ? -0.774  -18.632 6.174   1.00 16.85 ? 85  LEU A CD2 1 
ATOM   637  N N   . SER A 1 119 ? -0.563  -20.682 1.000   1.00 13.06 ? 86  SER A N   1 
ATOM   638  C CA  . SER A 1 119 ? -1.243  -21.496 -0.030  1.00 13.78 ? 86  SER A CA  1 
ATOM   639  C C   . SER A 1 119 ? -0.724  -22.947 -0.061  1.00 14.72 ? 86  SER A C   1 
ATOM   640  O O   . SER A 1 119 ? -1.369  -23.811 -0.731  1.00 15.35 ? 86  SER A O   1 
ATOM   641  C CB  . SER A 1 119 ? -1.098  -20.866 -1.361  1.00 13.33 ? 86  SER A CB  1 
ATOM   642  O OG  . SER A 1 119 ? 0.160   -21.196 -1.964  1.00 13.17 ? 86  SER A OG  1 
ATOM   643  N N   . PHE A 1 120 ? 0.470   -23.211 0.498   1.00 15.77 ? 87  PHE A N   1 
ATOM   644  C CA  . PHE A 1 120 ? 1.098   -24.559 0.425   1.00 15.29 ? 87  PHE A CA  1 
ATOM   645  C C   . PHE A 1 120 ? 0.434   -25.454 1.473   1.00 15.47 ? 87  PHE A C   1 
ATOM   646  O O   . PHE A 1 120 ? 0.019   -25.052 2.543   1.00 15.22 ? 87  PHE A O   1 
ATOM   647  C CB  . PHE A 1 120 ? 2.626   -24.442 0.497   1.00 14.29 ? 87  PHE A CB  1 
ATOM   648  C CG  . PHE A 1 120 ? 3.198   -23.861 -0.767  1.00 13.64 ? 87  PHE A CG  1 
ATOM   649  C CD1 . PHE A 1 120 ? 3.282   -24.616 -1.914  1.00 13.99 ? 87  PHE A CD1 1 
ATOM   650  C CD2 . PHE A 1 120 ? 3.466   -22.517 -0.843  1.00 12.42 ? 87  PHE A CD2 1 
ATOM   651  C CE1 . PHE A 1 120 ? 3.729   -24.074 -3.095  1.00 15.46 ? 87  PHE A CE1 1 
ATOM   652  C CE2 . PHE A 1 120 ? 3.939   -21.973 -2.015  1.00 13.87 ? 87  PHE A CE2 1 
ATOM   653  C CZ  . PHE A 1 120 ? 4.076   -22.743 -3.137  1.00 13.36 ? 87  PHE A CZ  1 
ATOM   654  N N   . PRO A 1 121 ? 0.408   -26.775 1.289   1.00 16.09 ? 88  PRO A N   1 
ATOM   655  C CA  . PRO A 1 121 ? 1.162   -27.442 0.243   1.00 16.41 ? 88  PRO A CA  1 
ATOM   656  C C   . PRO A 1 121 ? 0.516   -27.408 -1.144  1.00 17.97 ? 88  PRO A C   1 
ATOM   657  O O   . PRO A 1 121 ? 1.203   -27.731 -2.148  1.00 17.58 ? 88  PRO A O   1 
ATOM   658  C CB  . PRO A 1 121 ? 1.166   -28.921 0.707   1.00 18.42 ? 88  PRO A CB  1 
ATOM   659  C CG  . PRO A 1 121 ? -0.053  -29.023 1.573   1.00 18.13 ? 88  PRO A CG  1 
ATOM   660  C CD  . PRO A 1 121 ? -0.180  -27.687 2.277   1.00 19.71 ? 88  PRO A CD  1 
ATOM   661  N N   . GLU A 1 122 ? -0.774  -27.116 -1.236  1.00 16.90 ? 89  GLU A N   1 
ATOM   662  C CA  A GLU A 1 122 ? -1.395  -27.250 -2.571  0.50 16.65 ? 89  GLU A CA  1 
ATOM   663  C CA  B GLU A 1 122 ? -1.441  -27.204 -2.556  0.50 17.74 ? 89  GLU A CA  1 
ATOM   664  C C   . GLU A 1 122 ? -0.760  -26.231 -3.529  1.00 17.37 ? 89  GLU A C   1 
ATOM   665  O O   . GLU A 1 122 ? -0.505  -26.613 -4.667  1.00 15.00 ? 89  GLU A O   1 
ATOM   666  C CB  A GLU A 1 122 ? -2.911  -27.083 -2.550  0.50 16.32 ? 89  GLU A CB  1 
ATOM   667  C CB  B GLU A 1 122 ? -2.931  -26.879 -2.442  0.50 18.76 ? 89  GLU A CB  1 
ATOM   668  C CG  A GLU A 1 122 ? -3.556  -27.719 -3.758  0.50 15.96 ? 89  GLU A CG  1 
ATOM   669  C CG  B GLU A 1 122 ? -3.663  -27.787 -1.475  0.50 19.38 ? 89  GLU A CG  1 
ATOM   670  C CD  A GLU A 1 122 ? -5.055  -27.571 -3.802  0.50 14.26 ? 89  GLU A CD  1 
ATOM   671  C CD  B GLU A 1 122 ? -3.869  -27.245 -0.077  0.50 19.36 ? 89  GLU A CD  1 
ATOM   672  O OE1 A GLU A 1 122 ? -5.633  -27.176 -2.772  0.50 15.25 ? 89  GLU A OE1 1 
ATOM   673  O OE1 B GLU A 1 122 ? -2.900  -26.735 0.590   0.50 13.90 ? 89  GLU A OE1 1 
ATOM   674  O OE2 A GLU A 1 122 ? -5.597  -27.782 -4.862  0.50 12.77 ? 89  GLU A OE2 1 
ATOM   675  O OE2 B GLU A 1 122 ? -5.030  -27.294 0.311   0.50 19.93 ? 89  GLU A OE2 1 
ATOM   676  N N   . GLY A 1 123 ? -0.550  -25.001 -3.070  1.00 16.04 ? 90  GLY A N   1 
ATOM   677  C CA  . GLY A 1 123 ? 0.136   -23.956 -3.832  1.00 15.34 ? 90  GLY A CA  1 
ATOM   678  C C   . GLY A 1 123 ? -0.785  -22.938 -4.463  1.00 14.12 ? 90  GLY A C   1 
ATOM   679  O O   . GLY A 1 123 ? -1.902  -22.670 -3.978  1.00 13.70 ? 90  GLY A O   1 
ATOM   680  N N   . PHE A 1 124 ? -0.291  -22.351 -5.554  1.00 14.99 ? 91  PHE A N   1 
ATOM   681  C CA  . PHE A 1 124 ? -0.896  -21.180 -6.199  1.00 13.70 ? 91  PHE A CA  1 
ATOM   682  C C   . PHE A 1 124 ? -0.500  -21.206 -7.681  1.00 15.16 ? 91  PHE A C   1 
ATOM   683  O O   . PHE A 1 124 ? 0.416   -21.991 -8.098  1.00 13.12 ? 91  PHE A O   1 
ATOM   684  C CB  . PHE A 1 124 ? -0.420  -19.916 -5.490  1.00 11.89 ? 91  PHE A CB  1 
ATOM   685  C CG  . PHE A 1 124 ? 1.047   -19.548 -5.674  1.00 12.42 ? 91  PHE A CG  1 
ATOM   686  C CD1 . PHE A 1 124 ? 2.011   -20.026 -4.822  1.00 11.81 ? 91  PHE A CD1 1 
ATOM   687  C CD2 . PHE A 1 124 ? 1.457   -18.669 -6.680  1.00 12.95 ? 91  PHE A CD2 1 
ATOM   688  C CE1 . PHE A 1 124 ? 3.347   -19.655 -4.914  1.00 11.82 ? 91  PHE A CE1 1 
ATOM   689  C CE2 . PHE A 1 124 ? 2.785   -18.275 -6.760  1.00 12.08 ? 91  PHE A CE2 1 
ATOM   690  C CZ  . PHE A 1 124 ? 3.722   -18.786 -5.897  1.00 12.95 ? 91  PHE A CZ  1 
ATOM   691  N N   . LYS A 1 125 ? -1.205  -20.382 -8.430  1.00 12.88 ? 92  LYS A N   1 
ATOM   692  C CA  . LYS A 1 125 ? -0.912  -20.083 -9.843  1.00 14.05 ? 92  LYS A CA  1 
ATOM   693  C C   . LYS A 1 125 ? -0.622  -18.602 -9.991  1.00 14.05 ? 92  LYS A C   1 
ATOM   694  O O   . LYS A 1 125 ? -1.093  -17.772 -9.185  1.00 14.99 ? 92  LYS A O   1 
ATOM   695  C CB  . LYS A 1 125 ? -2.073  -20.425 -10.786 1.00 16.49 ? 92  LYS A CB  1 
ATOM   696  C CG  . LYS A 1 125 ? -2.499  -21.870 -10.737 1.00 22.18 ? 92  LYS A CG  1 
ATOM   697  C CD  . LYS A 1 125 ? -3.791  -22.152 -11.584 1.00 26.64 ? 92  LYS A CD  1 
ATOM   698  C CE  . LYS A 1 125 ? -4.293  -23.572 -11.346 1.00 35.07 ? 92  LYS A CE  1 
ATOM   699  N NZ  . LYS A 1 125 ? -3.230  -24.551 -11.674 1.00 37.27 ? 92  LYS A NZ  1 
ATOM   700  N N   . TRP A 1 126 ? 0.186   -18.286 -10.985 1.00 13.91 ? 93  TRP A N   1 
ATOM   701  C CA  . TRP A 1 126 ? 0.351   -16.867 -11.321 1.00 13.82 ? 93  TRP A CA  1 
ATOM   702  C C   . TRP A 1 126 ? 0.352   -16.643 -12.838 1.00 14.40 ? 93  TRP A C   1 
ATOM   703  O O   . TRP A 1 126 ? 0.631   -17.570 -13.644 1.00 14.09 ? 93  TRP A O   1 
ATOM   704  C CB  . TRP A 1 126 ? 1.560   -16.281 -10.621 1.00 13.39 ? 93  TRP A CB  1 
ATOM   705  C CG  . TRP A 1 126 ? 2.925   -16.849 -10.895 1.00 13.13 ? 93  TRP A CG  1 
ATOM   706  C CD1 . TRP A 1 126 ? 3.583   -17.826 -10.201 1.00 15.50 ? 93  TRP A CD1 1 
ATOM   707  C CD2 . TRP A 1 126 ? 3.883   -16.368 -11.863 1.00 12.52 ? 93  TRP A CD2 1 
ATOM   708  N NE1 . TRP A 1 126 ? 4.859   -18.000 -10.694 1.00 14.66 ? 93  TRP A NE1 1 
ATOM   709  C CE2 . TRP A 1 126 ? 5.065   -17.133 -11.739 1.00 12.90 ? 93  TRP A CE2 1 
ATOM   710  C CE3 . TRP A 1 126 ? 3.829   -15.434 -12.900 1.00 12.36 ? 93  TRP A CE3 1 
ATOM   711  C CZ2 . TRP A 1 126 ? 6.162   -16.990 -12.601 1.00 12.40 ? 93  TRP A CZ2 1 
ATOM   712  C CZ3 . TRP A 1 126 ? 4.939   -15.228 -13.710 1.00 12.59 ? 93  TRP A CZ3 1 
ATOM   713  C CH2 . TRP A 1 126 ? 6.126   -15.957 -13.510 1.00 12.53 ? 93  TRP A CH2 1 
ATOM   714  N N   . GLU A 1 127 ? -0.059  -15.445 -13.227 1.00 13.79 ? 94  GLU A N   1 
ATOM   715  C CA  . GLU A 1 127 ? -0.150  -15.066 -14.656 1.00 16.62 ? 94  GLU A CA  1 
ATOM   716  C C   . GLU A 1 127 ? 0.473   -13.681 -14.761 1.00 15.17 ? 94  GLU A C   1 
ATOM   717  O O   . GLU A 1 127 ? 0.154   -12.842 -13.908 1.00 15.19 ? 94  GLU A O   1 
ATOM   718  C CB  . GLU A 1 127 ? -1.560  -14.762 -15.145 1.00 19.64 ? 94  GLU A CB  1 
ATOM   719  C CG  . GLU A 1 127 ? -2.360  -15.879 -15.648 1.00 28.37 ? 94  GLU A CG  1 
ATOM   720  C CD  . GLU A 1 127 ? -3.626  -15.446 -16.413 1.00 24.49 ? 94  GLU A CD  1 
ATOM   721  O OE1 . GLU A 1 127 ? -4.207  -14.219 -16.291 1.00 18.02 ? 94  GLU A OE1 1 
ATOM   722  O OE2 . GLU A 1 127 ? -4.049  -16.342 -17.076 1.00 26.07 ? 94  GLU A OE2 1 
ATOM   723  N N   . ARG A 1 128 ? 1.240   -13.411 -15.805 1.00 12.69 ? 95  ARG A N   1 
ATOM   724  C CA  . ARG A 1 128 ? 1.984   -12.143 -15.873 1.00 12.16 ? 95  ARG A CA  1 
ATOM   725  C C   . ARG A 1 128 ? 1.955   -11.608 -17.302 1.00 13.34 ? 95  ARG A C   1 
ATOM   726  O O   . ARG A 1 128 ? 1.948   -12.397 -18.214 1.00 12.84 ? 95  ARG A O   1 
ATOM   727  C CB  . ARG A 1 128 ? 3.444   -12.354 -15.425 1.00 12.25 ? 95  ARG A CB  1 
ATOM   728  C CG  . ARG A 1 128 ? 4.292   -11.104 -15.505 1.00 12.27 ? 95  ARG A CG  1 
ATOM   729  C CD  . ARG A 1 128 ? 5.676   -11.403 -14.980 1.00 11.80 ? 95  ARG A CD  1 
ATOM   730  N NE  . ARG A 1 128 ? 5.621   -11.488 -13.516 1.00 11.98 ? 95  ARG A NE  1 
ATOM   731  C CZ  . ARG A 1 128 ? 6.522   -12.056 -12.755 1.00 11.89 ? 95  ARG A CZ  1 
ATOM   732  N NH1 . ARG A 1 128 ? 7.564   -12.666 -13.297 1.00 12.61 ? 95  ARG A NH1 1 
ATOM   733  N NH2 . ARG A 1 128 ? 6.337   -12.037 -11.439 1.00 11.61 ? 95  ARG A NH2 1 
ATOM   734  N N   . VAL A 1 129 ? 1.925   -10.287 -17.445 1.00 12.98 ? 96  VAL A N   1 
ATOM   735  C CA  . VAL A 1 129 ? 2.270   -9.643  -18.747 1.00 14.47 ? 96  VAL A CA  1 
ATOM   736  C C   . VAL A 1 129 ? 3.367   -8.631  -18.474 1.00 14.50 ? 96  VAL A C   1 
ATOM   737  O O   . VAL A 1 129 ? 3.292   -7.871  -17.456 1.00 13.03 ? 96  VAL A O   1 
ATOM   738  C CB  . VAL A 1 129 ? 1.076   -8.995  -19.488 1.00 15.21 ? 96  VAL A CB  1 
ATOM   739  C CG1 . VAL A 1 129 ? 0.359   -7.966  -18.651 1.00 15.32 ? 96  VAL A CG1 1 
ATOM   740  C CG2 . VAL A 1 129 ? 1.513   -8.311  -20.791 1.00 15.73 ? 96  VAL A CG2 1 
ATOM   741  N N   . MET A 1 130 ? 4.339   -8.610  -19.377 1.00 16.15 ? 97  MET A N   1 
ATOM   742  C CA  . MET A 1 130 ? 5.431   -7.604  -19.394 1.00 15.86 ? 97  MET A CA  1 
ATOM   743  C C   . MET A 1 130 ? 5.278   -6.870  -20.707 1.00 15.73 ? 97  MET A C   1 
ATOM   744  O O   . MET A 1 130 ? 5.350   -7.562  -21.750 1.00 16.13 ? 97  MET A O   1 
ATOM   745  C CB  . MET A 1 130 ? 6.792   -8.285  -19.311 1.00 16.32 ? 97  MET A CB  1 
ATOM   746  C CG  . MET A 1 130 ? 6.973   -9.179  -18.106 1.00 17.57 ? 97  MET A CG  1 
ATOM   747  S SD  . MET A 1 130 ? 8.684   -9.845  -18.169 1.00 16.54 ? 97  MET A SD  1 
ATOM   748  C CE  . MET A 1 130 ? 9.613   -8.457  -17.528 1.00 17.93 ? 97  MET A CE  1 
ATOM   749  N N   . ASN A 1 131 ? 5.014   -5.567  -20.649 1.00 16.73 ? 98  ASN A N   1 
ATOM   750  C CA  . ASN A 1 131 ? 4.974   -4.713  -21.879 1.00 18.33 ? 98  ASN A CA  1 
ATOM   751  C C   . ASN A 1 131 ? 6.277   -3.884  -21.955 1.00 17.92 ? 98  ASN A C   1 
ATOM   752  O O   . ASN A 1 131 ? 6.454   -2.910  -21.166 1.00 17.41 ? 98  ASN A O   1 
ATOM   753  C CB  . ASN A 1 131 ? 3.773   -3.780  -21.935 1.00 18.33 ? 98  ASN A CB  1 
ATOM   754  C CG  . ASN A 1 131 ? 2.425   -4.457  -22.167 1.00 21.90 ? 98  ASN A CG  1 
ATOM   755  O OD1 . ASN A 1 131 ? 2.104   -4.913  -23.269 1.00 30.60 ? 98  ASN A OD1 1 
ATOM   756  N ND2 . ASN A 1 131 ? 1.586   -4.445  -21.155 1.00 21.42 ? 98  ASN A ND2 1 
ATOM   757  N N   . PHE A 1 132 ? 7.177   -4.288  -22.846 1.00 17.85 ? 99  PHE A N   1 
ATOM   758  C CA  . PHE A 1 132 ? 8.490   -3.619  -23.029 1.00 17.91 ? 99  PHE A CA  1 
ATOM   759  C C   . PHE A 1 132 ? 8.295   -2.373  -23.887 1.00 19.52 ? 99  PHE A C   1 
ATOM   760  O O   . PHE A 1 132 ? 7.375   -2.333  -24.763 1.00 20.96 ? 99  PHE A O   1 
ATOM   761  C CB  . PHE A 1 132 ? 9.515   -4.560  -23.636 1.00 17.47 ? 99  PHE A CB  1 
ATOM   762  C CG  . PHE A 1 132 ? 9.940   -5.682  -22.728 1.00 17.24 ? 99  PHE A CG  1 
ATOM   763  C CD1 . PHE A 1 132 ? 10.994  -5.489  -21.842 1.00 17.62 ? 99  PHE A CD1 1 
ATOM   764  C CD2 . PHE A 1 132 ? 9.248   -6.884  -22.719 1.00 16.70 ? 99  PHE A CD2 1 
ATOM   765  C CE1 . PHE A 1 132 ? 11.393  -6.506  -20.985 1.00 18.56 ? 99  PHE A CE1 1 
ATOM   766  C CE2 . PHE A 1 132 ? 9.651   -7.892  -21.867 1.00 16.79 ? 99  PHE A CE2 1 
ATOM   767  C CZ  . PHE A 1 132 ? 10.733  -7.714  -21.031 1.00 16.93 ? 99  PHE A CZ  1 
ATOM   768  N N   . GLU A 1 133 ? 9.156   -1.389  -23.626 1.00 18.97 ? 100 GLU A N   1 
ATOM   769  C CA  . GLU A 1 133 ? 9.013   0.001   -24.144 1.00 21.79 ? 100 GLU A CA  1 
ATOM   770  C C   . GLU A 1 133 ? 9.103   -0.009  -25.675 1.00 20.85 ? 100 GLU A C   1 
ATOM   771  O O   . GLU A 1 133 ? 8.556   0.908   -26.203 1.00 21.64 ? 100 GLU A O   1 
ATOM   772  C CB  . GLU A 1 133 ? 10.036  0.961   -23.519 1.00 22.73 ? 100 GLU A CB  1 
ATOM   773  C CG  . GLU A 1 133 ? 11.479  0.678   -23.898 1.00 23.43 ? 100 GLU A CG  1 
ATOM   774  C CD  . GLU A 1 133 ? 12.409  1.711   -23.317 1.00 27.34 ? 100 GLU A CD  1 
ATOM   775  O OE1 . GLU A 1 133 ? 12.839  1.588   -22.163 1.00 25.21 ? 100 GLU A OE1 1 
ATOM   776  O OE2 . GLU A 1 133 ? 12.623  2.697   -24.015 1.00 30.97 ? 100 GLU A OE2 1 
ATOM   777  N N   . ASP A 1 134 ? 9.640   -1.053  -26.327 1.00 22.33 ? 101 ASP A N   1 
ATOM   778  C CA  . ASP A 1 134 ? 9.837   -1.106  -27.808 1.00 21.32 ? 101 ASP A CA  1 
ATOM   779  C C   . ASP A 1 134 ? 8.766   -1.993  -28.466 1.00 21.05 ? 101 ASP A C   1 
ATOM   780  O O   . ASP A 1 134 ? 8.965   -2.300  -29.664 1.00 22.62 ? 101 ASP A O   1 
ATOM   781  C CB  . ASP A 1 134 ? 11.279  -1.494  -28.160 1.00 20.26 ? 101 ASP A CB  1 
ATOM   782  C CG  . ASP A 1 134 ? 11.674  -2.899  -27.752 1.00 21.16 ? 101 ASP A CG  1 
ATOM   783  O OD1 . ASP A 1 134 ? 10.876  -3.519  -26.976 1.00 21.65 ? 101 ASP A OD1 1 
ATOM   784  O OD2 . ASP A 1 134 ? 12.755  -3.372  -28.192 1.00 21.48 ? 101 ASP A OD2 1 
ATOM   785  N N   . GLY A 1 135 ? 7.730   -2.421  -27.716 1.00 19.79 ? 102 GLY A N   1 
ATOM   786  C CA  . GLY A 1 135 ? 6.556   -3.208  -28.185 1.00 21.70 ? 102 GLY A CA  1 
ATOM   787  C C   . GLY A 1 135 ? 6.718   -4.721  -27.955 1.00 19.11 ? 102 GLY A C   1 
ATOM   788  O O   . GLY A 1 135 ? 5.800   -5.491  -28.217 1.00 19.83 ? 102 GLY A O   1 
ATOM   789  N N   . GLY A 1 136 ? 7.885   -5.186  -27.483 1.00 18.47 ? 103 GLY A N   1 
ATOM   790  C CA  . GLY A 1 136 ? 7.998   -6.589  -27.090 1.00 17.79 ? 103 GLY A CA  1 
ATOM   791  C C   . GLY A 1 136 ? 6.999   -6.882  -25.982 1.00 16.00 ? 103 GLY A C   1 
ATOM   792  O O   . GLY A 1 136 ? 6.782   -6.022  -25.127 1.00 16.66 ? 103 GLY A O   1 
ATOM   793  N N   . VAL A 1 137 ? 6.466   -8.090  -25.960 1.00 15.74 ? 104 VAL A N   1 
ATOM   794  C CA  . VAL A 1 137 ? 5.513   -8.514  -24.910 1.00 17.13 ? 104 VAL A CA  1 
ATOM   795  C C   . VAL A 1 137 ? 5.846   -9.957  -24.494 1.00 15.62 ? 104 VAL A C   1 
ATOM   796  O O   . VAL A 1 137 ? 6.186   -10.824 -25.315 1.00 17.03 ? 104 VAL A O   1 
ATOM   797  C CB  . VAL A 1 137 ? 4.039   -8.341  -25.325 1.00 18.81 ? 104 VAL A CB  1 
ATOM   798  C CG1 . VAL A 1 137 ? 3.110   -8.918  -24.265 1.00 19.74 ? 104 VAL A CG1 1 
ATOM   799  C CG2 . VAL A 1 137 ? 3.676   -6.886  -25.596 1.00 25.29 ? 104 VAL A CG2 1 
ATOM   800  N N   . VAL A 1 138 ? 5.795   -10.193 -23.194 1.00 15.16 ? 105 VAL A N   1 
ATOM   801  C CA  . VAL A 1 138 ? 5.896   -11.533 -22.613 1.00 14.79 ? 105 VAL A CA  1 
ATOM   802  C C   . VAL A 1 138 ? 4.621   -11.718 -21.803 1.00 13.09 ? 105 VAL A C   1 
ATOM   803  O O   . VAL A 1 138 ? 4.303   -10.891 -20.941 1.00 13.75 ? 105 VAL A O   1 
ATOM   804  C CB  . VAL A 1 138 ? 7.148   -11.703 -21.739 1.00 14.78 ? 105 VAL A CB  1 
ATOM   805  C CG1 . VAL A 1 138 ? 7.146   -13.066 -21.039 1.00 18.64 ? 105 VAL A CG1 1 
ATOM   806  C CG2 . VAL A 1 138 ? 8.425   -11.573 -22.558 1.00 15.62 ? 105 VAL A CG2 1 
ATOM   807  N N   . THR A 1 139 ? 3.972   -12.832 -22.040 1.00 14.13 ? 106 THR A N   1 
ATOM   808  C CA  . THR A 1 139 ? 2.913   -13.351 -21.159 1.00 15.06 ? 106 THR A CA  1 
ATOM   809  C C   . THR A 1 139 ? 3.385   -14.703 -20.600 1.00 14.89 ? 106 THR A C   1 
ATOM   810  O O   . THR A 1 139 ? 4.146   -15.426 -21.242 1.00 15.09 ? 106 THR A O   1 
ATOM   811  C CB  . THR A 1 139 ? 1.551   -13.505 -21.836 1.00 14.99 ? 106 THR A CB  1 
ATOM   812  O OG1 . THR A 1 139 ? 1.629   -14.443 -22.911 1.00 16.32 ? 106 THR A OG1 1 
ATOM   813  C CG2 . THR A 1 139 ? 1.022   -12.169 -22.325 1.00 15.27 ? 106 THR A CG2 1 
ATOM   814  N N   . VAL A 1 140 ? 3.005   -14.938 -19.356 1.00 14.33 ? 107 VAL A N   1 
ATOM   815  C CA  . VAL A 1 140 ? 3.397   -16.131 -18.575 1.00 15.38 ? 107 VAL A CA  1 
ATOM   816  C C   . VAL A 1 140 ? 2.155   -16.714 -17.900 1.00 15.44 ? 107 VAL A C   1 
ATOM   817  O O   . VAL A 1 140 ? 1.340   -15.928 -17.338 1.00 13.24 ? 107 VAL A O   1 
ATOM   818  C CB  . VAL A 1 140 ? 4.424   -15.744 -17.498 1.00 14.15 ? 107 VAL A CB  1 
ATOM   819  C CG1 . VAL A 1 140 ? 4.895   -16.985 -16.734 1.00 15.56 ? 107 VAL A CG1 1 
ATOM   820  C CG2 . VAL A 1 140 ? 5.573   -14.933 -18.055 1.00 14.18 ? 107 VAL A CG2 1 
ATOM   821  N N   . THR A 1 141 ? 2.130   -18.038 -17.786 1.00 13.83 ? 108 THR A N   1 
ATOM   822  C CA  . THR A 1 141 ? 1.225   -18.767 -16.869 1.00 16.73 ? 108 THR A CA  1 
ATOM   823  C C   . THR A 1 141 ? 2.094   -19.775 -16.119 1.00 15.38 ? 108 THR A C   1 
ATOM   824  O O   . THR A 1 141 ? 3.081   -20.282 -16.691 1.00 13.07 ? 108 THR A O   1 
ATOM   825  C CB  . THR A 1 141 ? 0.018   -19.445 -17.531 1.00 18.52 ? 108 THR A CB  1 
ATOM   826  O OG1 . THR A 1 141 ? 0.465   -20.520 -18.359 1.00 19.16 ? 108 THR A OG1 1 
ATOM   827  C CG2 . THR A 1 141 ? -0.817  -18.473 -18.333 1.00 16.92 ? 108 THR A CG2 1 
ATOM   828  N N   . GLN A 1 142 ? 1.799   -19.987 -14.826 1.00 15.32 ? 109 GLN A N   1 
ATOM   829  C CA  . GLN A 1 142 ? 2.711   -20.722 -13.940 1.00 13.49 ? 109 GLN A CA  1 
ATOM   830  C C   . GLN A 1 142 ? 1.885   -21.438 -12.882 1.00 13.88 ? 109 GLN A C   1 
ATOM   831  O O   . GLN A 1 142 ? 0.909   -20.881 -12.380 1.00 12.77 ? 109 GLN A O   1 
ATOM   832  C CB  . GLN A 1 142 ? 3.750   -19.789 -13.297 1.00 14.06 ? 109 GLN A CB  1 
ATOM   833  C CG  . GLN A 1 142 ? 4.982   -20.545 -12.765 1.00 15.16 ? 109 GLN A CG  1 
ATOM   834  C CD  . GLN A 1 142 ? 4.991   -21.043 -11.336 1.00 13.74 ? 109 GLN A CD  1 
ATOM   835  O OE1 . GLN A 1 142 ? 6.067   -21.377 -10.764 1.00 16.64 ? 109 GLN A OE1 1 
ATOM   836  N NE2 . GLN A 1 142 ? 3.868   -21.030 -10.690 1.00 12.53 ? 109 GLN A NE2 1 
ATOM   837  N N   . ASP A 1 143 ? 2.303   -22.674 -12.564 1.00 14.20 ? 110 ASP A N   1 
ATOM   838  C CA  . ASP A 1 143 ? 1.737   -23.462 -11.454 1.00 15.27 ? 110 ASP A CA  1 
ATOM   839  C C   . ASP A 1 143 ? 2.852   -23.719 -10.449 1.00 13.65 ? 110 ASP A C   1 
ATOM   840  O O   . ASP A 1 143 ? 3.959   -24.179 -10.877 1.00 14.38 ? 110 ASP A O   1 
ATOM   841  C CB  . ASP A 1 143 ? 1.181   -24.789 -11.956 1.00 15.60 ? 110 ASP A CB  1 
ATOM   842  C CG  . ASP A 1 143 ? 0.366   -25.467 -10.873 1.00 18.64 ? 110 ASP A CG  1 
ATOM   843  O OD1 . ASP A 1 143 ? -0.803  -25.211 -10.803 1.00 21.36 ? 110 ASP A OD1 1 
ATOM   844  O OD2 . ASP A 1 143 ? 0.922   -26.226 -10.121 1.00 22.59 ? 110 ASP A OD2 1 
ATOM   845  N N   . SER A 1 144 ? 2.550   -23.548 -9.174  1.00 13.87 ? 111 SER A N   1 
ATOM   846  C CA  . SER A 1 144 ? 3.457   -23.853 -8.049  1.00 14.08 ? 111 SER A CA  1 
ATOM   847  C C   . SER A 1 144 ? 2.768   -24.796 -7.071  1.00 14.89 ? 111 SER A C   1 
ATOM   848  O O   . SER A 1 144 ? 1.604   -24.537 -6.731  1.00 14.15 ? 111 SER A O   1 
ATOM   849  C CB  . SER A 1 144 ? 3.873   -22.578 -7.358  1.00 13.54 ? 111 SER A CB  1 
ATOM   850  O OG  . SER A 1 144 ? 4.531   -21.777 -8.282  1.00 14.60 ? 111 SER A OG  1 
ATOM   851  N N   . SER A 1 145 ? 3.442   -25.856 -6.636  1.00 13.89 ? 112 SER A N   1 
ATOM   852  C CA  . SER A 1 145 ? 2.900   -26.846 -5.671  1.00 16.08 ? 112 SER A CA  1 
ATOM   853  C C   . SER A 1 145 ? 4.080   -27.376 -4.879  1.00 16.44 ? 112 SER A C   1 
ATOM   854  O O   . SER A 1 145 ? 5.200   -26.965 -5.158  1.00 14.14 ? 112 SER A O   1 
ATOM   855  C CB  . SER A 1 145 ? 2.182   -27.971 -6.368  1.00 17.17 ? 112 SER A CB  1 
ATOM   856  O OG  . SER A 1 145 ? 3.057   -28.523 -7.314  1.00 18.91 ? 112 SER A OG  1 
ATOM   857  N N   . LEU A 1 146 ? 3.813   -28.203 -3.886  1.00 16.41 ? 113 LEU A N   1 
ATOM   858  C CA  . LEU A 1 146 ? 4.835   -28.721 -2.966  1.00 18.61 ? 113 LEU A CA  1 
ATOM   859  C C   . LEU A 1 146 ? 4.579   -30.216 -2.928  1.00 18.87 ? 113 LEU A C   1 
ATOM   860  O O   . LEU A 1 146 ? 3.449   -30.576 -2.658  1.00 18.11 ? 113 LEU A O   1 
ATOM   861  C CB  . LEU A 1 146 ? 4.651   -28.074 -1.602  1.00 22.50 ? 113 LEU A CB  1 
ATOM   862  C CG  . LEU A 1 146 ? 5.717   -28.454 -0.564  1.00 26.21 ? 113 LEU A CG  1 
ATOM   863  C CD1 . LEU A 1 146 ? 7.015   -27.848 -0.924  1.00 28.91 ? 113 LEU A CD1 1 
ATOM   864  C CD2 . LEU A 1 146 ? 5.349   -28.001 0.827   1.00 29.59 ? 113 LEU A CD2 1 
ATOM   865  N N   . GLN A 1 147 ? 5.512   -30.976 -3.461  1.00 17.82 ? 114 GLN A N   1 
ATOM   866  C CA  . GLN A 1 147 ? 5.426   -32.429 -3.641  1.00 20.38 ? 114 GLN A CA  1 
ATOM   867  C C   . GLN A 1 147 ? 6.724   -33.016 -3.086  1.00 19.75 ? 114 GLN A C   1 
ATOM   868  O O   . GLN A 1 147 ? 7.813   -32.521 -3.451  1.00 18.67 ? 114 GLN A O   1 
ATOM   869  C CB  . GLN A 1 147 ? 5.159   -32.743 -5.118  1.00 23.28 ? 114 GLN A CB  1 
ATOM   870  C CG  . GLN A 1 147 ? 3.787   -32.264 -5.608  1.00 29.56 ? 114 GLN A CG  1 
ATOM   871  C CD  . GLN A 1 147 ? 3.619   -32.416 -7.111  1.00 32.72 ? 114 GLN A CD  1 
ATOM   872  O OE1 . GLN A 1 147 ? 3.057   -31.566 -7.814  1.00 34.47 ? 114 GLN A OE1 1 
ATOM   873  N NE2 . GLN A 1 147 ? 4.147   -33.501 -7.645  1.00 36.62 ? 114 GLN A NE2 1 
ATOM   874  N N   . ASP A 1 148 ? 6.629   -34.032 -2.212  1.00 20.58 ? 115 ASP A N   1 
ATOM   875  C CA  . ASP A 1 148 ? 7.795   -34.830 -1.776  1.00 23.81 ? 115 ASP A CA  1 
ATOM   876  C C   . ASP A 1 148 ? 8.834   -33.896 -1.157  1.00 22.02 ? 115 ASP A C   1 
ATOM   877  O O   . ASP A 1 148 ? 9.996   -34.056 -1.463  1.00 24.63 ? 115 ASP A O   1 
ATOM   878  C CB  . ASP A 1 148 ? 8.303   -35.649 -2.952  1.00 27.33 ? 115 ASP A CB  1 
ATOM   879  C CG  . ASP A 1 148 ? 7.187   -36.499 -3.561  1.00 29.82 ? 115 ASP A CG  1 
ATOM   880  O OD1 . ASP A 1 148 ? 6.336   -37.025 -2.762  1.00 26.73 ? 115 ASP A OD1 1 
ATOM   881  O OD2 . ASP A 1 148 ? 7.119   -36.571 -4.833  1.00 34.31 ? 115 ASP A OD2 1 
ATOM   882  N N   . GLY A 1 149 ? 8.389   -32.898 -0.409  1.00 20.48 ? 116 GLY A N   1 
ATOM   883  C CA  . GLY A 1 149 ? 9.256   -31.985 0.382   1.00 22.13 ? 116 GLY A CA  1 
ATOM   884  C C   . GLY A 1 149 ? 9.883   -30.841 -0.424  1.00 19.95 ? 116 GLY A C   1 
ATOM   885  O O   . GLY A 1 149 ? 10.701  -30.095 0.143   1.00 21.30 ? 116 GLY A O   1 
ATOM   886  N N   . GLU A 1 150 ? 9.583   -30.742 -1.729  1.00 18.02 ? 117 GLU A N   1 
ATOM   887  C CA  . GLU A 1 150 ? 10.199  -29.726 -2.617  1.00 17.97 ? 117 GLU A CA  1 
ATOM   888  C C   . GLU A 1 150 ? 9.078   -28.931 -3.302  1.00 15.56 ? 117 GLU A C   1 
ATOM   889  O O   . GLU A 1 150 ? 8.038   -29.512 -3.662  1.00 15.82 ? 117 GLU A O   1 
ATOM   890  C CB  . GLU A 1 150 ? 11.116  -30.364 -3.656  1.00 18.67 ? 117 GLU A CB  1 
ATOM   891  C CG  . GLU A 1 150 ? 12.293  -31.102 -3.028  1.00 21.72 ? 117 GLU A CG  1 
ATOM   892  C CD  . GLU A 1 150 ? 13.428  -31.426 -3.987  1.00 25.66 ? 117 GLU A CD  1 
ATOM   893  O OE1 . GLU A 1 150 ? 14.380  -32.072 -3.561  1.00 25.93 ? 117 GLU A OE1 1 
ATOM   894  O OE2 . GLU A 1 150 ? 13.371  -30.992 -5.136  1.00 27.53 ? 117 GLU A OE2 1 
ATOM   895  N N   . PHE A 1 151 ? 9.307   -27.649 -3.579  1.00 15.40 ? 118 PHE A N   1 
ATOM   896  C CA  . PHE A 1 151 ? 8.404   -26.893 -4.459  1.00 13.57 ? 118 PHE A CA  1 
ATOM   897  C C   . PHE A 1 151 ? 8.584   -27.443 -5.877  1.00 13.54 ? 118 PHE A C   1 
ATOM   898  O O   . PHE A 1 151 ? 9.757   -27.738 -6.315  1.00 13.19 ? 118 PHE A O   1 
ATOM   899  C CB  . PHE A 1 151 ? 8.726   -25.387 -4.411  1.00 12.93 ? 118 PHE A CB  1 
ATOM   900  C CG  . PHE A 1 151 ? 8.560   -24.750 -3.076  1.00 11.52 ? 118 PHE A CG  1 
ATOM   901  C CD1 . PHE A 1 151 ? 7.306   -24.707 -2.496  1.00 13.76 ? 118 PHE A CD1 1 
ATOM   902  C CD2 . PHE A 1 151 ? 9.618   -24.204 -2.380  1.00 12.64 ? 118 PHE A CD2 1 
ATOM   903  C CE1 . PHE A 1 151 ? 7.093   -24.035 -1.303  1.00 14.14 ? 118 PHE A CE1 1 
ATOM   904  C CE2 . PHE A 1 151 ? 9.433   -23.583 -1.162  1.00 13.64 ? 118 PHE A CE2 1 
ATOM   905  C CZ  . PHE A 1 151 ? 8.162   -23.543 -0.589  1.00 14.86 ? 118 PHE A CZ  1 
ATOM   906  N N   . ILE A 1 152 ? 7.480   -27.459 -6.608  1.00 13.79 ? 119 ILE A N   1 
ATOM   907  C CA  . ILE A 1 152 ? 7.443   -27.853 -8.052  1.00 15.21 ? 119 ILE A CA  1 
ATOM   908  C C   . ILE A 1 152 ? 6.835   -26.722 -8.863  1.00 14.04 ? 119 ILE A C   1 
ATOM   909  O O   . ILE A 1 152 ? 5.732   -26.314 -8.559  1.00 15.23 ? 119 ILE A O   1 
ATOM   910  C CB  . ILE A 1 152 ? 6.697   -29.165 -8.260  1.00 16.67 ? 119 ILE A CB  1 
ATOM   911  C CG1 . ILE A 1 152 ? 7.257   -30.325 -7.421  1.00 21.60 ? 119 ILE A CG1 1 
ATOM   912  C CG2 . ILE A 1 152 ? 6.678   -29.511 -9.741  1.00 16.88 ? 119 ILE A CG2 1 
ATOM   913  C CD1 . ILE A 1 152 ? 8.622   -30.803 -7.853  1.00 22.84 ? 119 ILE A CD1 1 
ATOM   914  N N   . TYR A 1 153 ? 7.602   -26.191 -9.811  1.00 14.13 ? 120 TYR A N   1 
ATOM   915  C CA  . TYR A 1 153 ? 7.193   -25.074 -10.664 1.00 13.80 ? 120 TYR A CA  1 
ATOM   916  C C   . TYR A 1 153 ? 7.063   -25.574 -12.107 1.00 14.20 ? 120 TYR A C   1 
ATOM   917  O O   . TYR A 1 153 ? 7.988   -26.209 -12.587 1.00 16.56 ? 120 TYR A O   1 
ATOM   918  C CB  . TYR A 1 153 ? 8.193   -23.918 -10.625 1.00 13.35 ? 120 TYR A CB  1 
ATOM   919  C CG  . TYR A 1 153 ? 8.496   -23.341 -9.255  1.00 12.92 ? 120 TYR A CG  1 
ATOM   920  C CD1 . TYR A 1 153 ? 7.610   -23.404 -8.208  1.00 13.57 ? 120 TYR A CD1 1 
ATOM   921  C CD2 . TYR A 1 153 ? 9.708   -22.689 -9.038  1.00 14.13 ? 120 TYR A CD2 1 
ATOM   922  C CE1 . TYR A 1 153 ? 7.949   -22.912 -6.975  1.00 14.08 ? 120 TYR A CE1 1 
ATOM   923  C CE2 . TYR A 1 153 ? 10.038  -22.123 -7.824  1.00 14.38 ? 120 TYR A CE2 1 
ATOM   924  C CZ  . TYR A 1 153 ? 9.145   -22.225 -6.789  1.00 15.03 ? 120 TYR A CZ  1 
ATOM   925  O OH  . TYR A 1 153 ? 9.444   -21.661 -5.585  1.00 14.29 ? 120 TYR A OH  1 
ATOM   926  N N   . LYS A 1 154 ? 5.941   -25.243 -12.766 1.00 13.06 ? 121 LYS A N   1 
ATOM   927  C CA  . LYS A 1 154 ? 5.701   -25.522 -14.188 1.00 12.34 ? 121 LYS A CA  1 
ATOM   928  C C   . LYS A 1 154 ? 5.329   -24.188 -14.828 1.00 13.49 ? 121 LYS A C   1 
ATOM   929  O O   . LYS A 1 154 ? 4.265   -23.648 -14.442 1.00 13.41 ? 121 LYS A O   1 
ATOM   930  C CB  . LYS A 1 154 ? 4.553   -26.525 -14.333 1.00 14.35 ? 121 LYS A CB  1 
ATOM   931  C CG  . LYS A 1 154 ? 4.711   -27.840 -13.603 1.00 16.31 ? 121 LYS A CG  1 
ATOM   932  N N   . VAL A 1 155 ? 6.160   -23.689 -15.725 1.00 14.10 ? 122 VAL A N   1 
ATOM   933  C CA  . VAL A 1 155 ? 6.022   -22.334 -16.308 1.00 15.19 ? 122 VAL A CA  1 
ATOM   934  C C   . VAL A 1 155 ? 5.792   -22.471 -17.825 1.00 15.16 ? 122 VAL A C   1 
ATOM   935  O O   . VAL A 1 155 ? 6.421   -23.335 -18.454 1.00 14.56 ? 122 VAL A O   1 
ATOM   936  C CB  . VAL A 1 155 ? 7.270   -21.484 -16.046 1.00 14.94 ? 122 VAL A CB  1 
ATOM   937  C CG1 . VAL A 1 155 ? 6.947   -19.989 -16.211 1.00 17.34 ? 122 VAL A CG1 1 
ATOM   938  C CG2 . VAL A 1 155 ? 7.907   -21.794 -14.706 1.00 17.19 ? 122 VAL A CG2 1 
ATOM   939  N N   . LYS A 1 156 ? 4.987   -21.556 -18.386 1.00 16.24 ? 123 LYS A N   1 
ATOM   940  C CA  . LYS A 1 156 ? 4.749   -21.421 -19.835 1.00 15.33 ? 123 LYS A CA  1 
ATOM   941  C C   . LYS A 1 156 ? 4.943   -19.959 -20.203 1.00 15.97 ? 123 LYS A C   1 
ATOM   942  O O   . LYS A 1 156 ? 4.257   -19.045 -19.607 1.00 16.53 ? 123 LYS A O   1 
ATOM   943  C CB  . LYS A 1 156 ? 3.336   -21.858 -20.247 1.00 16.93 ? 123 LYS A CB  1 
ATOM   944  C CG  . LYS A 1 156 ? 2.972   -23.270 -19.847 1.00 22.10 ? 123 LYS A CG  1 
ATOM   945  C CD  . LYS A 1 156 ? 1.662   -23.819 -20.425 1.00 25.71 ? 123 LYS A CD  1 
ATOM   946  C CE  . LYS A 1 156 ? 1.343   -25.151 -19.779 1.00 29.85 ? 123 LYS A CE  1 
ATOM   947  N NZ  . LYS A 1 156 ? 0.134   -25.783 -20.365 1.00 38.12 ? 123 LYS A NZ  1 
ATOM   948  N N   . VAL A 1 157 ? 5.873   -19.705 -21.108 1.00 15.19 ? 124 VAL A N   1 
ATOM   949  C CA  . VAL A 1 157 ? 6.283   -18.317 -21.414 1.00 15.04 ? 124 VAL A CA  1 
ATOM   950  C C   . VAL A 1 157 ? 6.025   -18.104 -22.889 1.00 15.51 ? 124 VAL A C   1 
ATOM   951  O O   . VAL A 1 157 ? 6.452   -18.945 -23.679 1.00 18.35 ? 124 VAL A O   1 
ATOM   952  C CB  . VAL A 1 157 ? 7.757   -18.139 -21.053 1.00 16.38 ? 124 VAL A CB  1 
ATOM   953  C CG1 . VAL A 1 157 ? 8.252   -16.768 -21.450 1.00 16.49 ? 124 VAL A CG1 1 
ATOM   954  C CG2 . VAL A 1 157 ? 7.988   -18.432 -19.586 1.00 18.16 ? 124 VAL A CG2 1 
ATOM   955  N N   . ARG A 1 158 ? 5.432   -16.983 -23.233 1.00 16.82 ? 125 ARG A N   1 
ATOM   956  C CA  . ARG A 1 158 ? 5.198   -16.621 -24.637 1.00 16.72 ? 125 ARG A CA  1 
ATOM   957  C C   . ARG A 1 158 ? 5.649   -15.192 -24.830 1.00 17.41 ? 125 ARG A C   1 
ATOM   958  O O   . ARG A 1 158 ? 4.963   -14.335 -24.272 1.00 18.97 ? 125 ARG A O   1 
ATOM   959  C CB  . ARG A 1 158 ? 3.712   -16.772 -24.983 1.00 18.81 ? 125 ARG A CB  1 
ATOM   960  C CG  . ARG A 1 158 ? 3.269   -18.223 -24.996 1.00 21.73 ? 125 ARG A CG  1 
ATOM   961  C CD  . ARG A 1 158 ? 3.940   -19.070 -26.082 1.00 22.99 ? 125 ARG A CD  1 
ATOM   962  N NE  . ARG A 1 158 ? 3.399   -20.396 -25.883 1.00 24.70 ? 125 ARG A NE  1 
ATOM   963  C CZ  . ARG A 1 158 ? 3.947   -21.529 -26.287 1.00 29.88 ? 125 ARG A CZ  1 
ATOM   964  N NH1 . ARG A 1 158 ? 5.054   -21.538 -26.999 1.00 29.99 ? 125 ARG A NH1 1 
ATOM   965  N NH2 . ARG A 1 158 ? 3.348   -22.671 -26.007 1.00 33.31 ? 125 ARG A NH2 1 
ATOM   966  N N   . GLY A 1 159 ? 6.717   -14.991 -25.612 1.00 16.88 ? 126 GLY A N   1 
ATOM   967  C CA  . GLY A 1 159 ? 7.190   -13.668 -26.024 1.00 16.75 ? 126 GLY A CA  1 
ATOM   968  C C   . GLY A 1 159 ? 6.936   -13.443 -27.515 1.00 14.69 ? 126 GLY A C   1 
ATOM   969  O O   . GLY A 1 159 ? 7.074   -14.396 -28.307 1.00 14.78 ? 126 GLY A O   1 
ATOM   970  N N   . THR A 1 160 ? 6.650   -12.213 -27.890 1.00 17.19 ? 127 THR A N   1 
ATOM   971  C CA  . THR A 1 160 ? 6.436   -11.855 -29.301 1.00 18.18 ? 127 THR A CA  1 
ATOM   972  C C   . THR A 1 160 ? 6.590   -10.365 -29.511 1.00 17.50 ? 127 THR A C   1 
ATOM   973  O O   . THR A 1 160 ? 6.640   -9.534  -28.526 1.00 17.40 ? 127 THR A O   1 
ATOM   974  C CB  . THR A 1 160 ? 5.089   -12.366 -29.826 1.00 21.33 ? 127 THR A CB  1 
ATOM   975  O OG1 . THR A 1 160 ? 5.157   -12.279 -31.264 1.00 26.75 ? 127 THR A OG1 1 
ATOM   976  C CG2 . THR A 1 160 ? 3.928   -11.543 -29.292 1.00 22.02 ? 127 THR A CG2 1 
ATOM   977  N N   . ASN A 1 161 ? 6.758   -10.041 -30.794 1.00 18.65 ? 128 ASN A N   1 
ATOM   978  C CA  . ASN A 1 161 ? 6.870   -8.633  -31.270 1.00 18.66 ? 128 ASN A CA  1 
ATOM   979  C C   . ASN A 1 161 ? 8.142   -7.930  -30.762 1.00 18.14 ? 128 ASN A C   1 
ATOM   980  O O   . ASN A 1 161 ? 8.147   -6.666  -30.698 1.00 16.85 ? 128 ASN A O   1 
ATOM   981  C CB  . ASN A 1 161 ? 5.638   -7.861  -30.852 1.00 20.77 ? 128 ASN A CB  1 
ATOM   982  C CG  . ASN A 1 161 ? 5.463   -6.591  -31.647 1.00 20.43 ? 128 ASN A CG  1 
ATOM   983  O OD1 . ASN A 1 161 ? 5.648   -6.584  -32.854 1.00 23.30 ? 128 ASN A OD1 1 
ATOM   984  N ND2 . ASN A 1 161 ? 5.012   -5.551  -30.999 1.00 20.56 ? 128 ASN A ND2 1 
ATOM   985  N N   . PHE A 1 162 ? 9.182   -8.689  -30.355 1.00 18.78 ? 129 PHE A N   1 
ATOM   986  C CA  . PHE A 1 162 ? 10.513  -8.081  -30.054 1.00 19.26 ? 129 PHE A CA  1 
ATOM   987  C C   . PHE A 1 162 ? 11.148  -7.676  -31.379 1.00 20.34 ? 129 PHE A C   1 
ATOM   988  O O   . PHE A 1 162 ? 11.282  -8.493  -32.252 1.00 20.16 ? 129 PHE A O   1 
ATOM   989  C CB  . PHE A 1 162 ? 11.429  -9.008  -29.261 1.00 20.30 ? 129 PHE A CB  1 
ATOM   990  C CG  . PHE A 1 162 ? 10.972  -9.117  -27.829 1.00 17.66 ? 129 PHE A CG  1 
ATOM   991  C CD1 . PHE A 1 162 ? 11.270  -8.121  -26.919 1.00 16.00 ? 129 PHE A CD1 1 
ATOM   992  C CD2 . PHE A 1 162 ? 10.249  -10.223 -27.419 1.00 19.05 ? 129 PHE A CD2 1 
ATOM   993  C CE1 . PHE A 1 162 ? 10.845  -8.216  -25.602 1.00 16.93 ? 129 PHE A CE1 1 
ATOM   994  C CE2 . PHE A 1 162 ? 9.813   -10.312 -26.113 1.00 16.86 ? 129 PHE A CE2 1 
ATOM   995  C CZ  . PHE A 1 162 ? 10.146  -9.336  -25.206 1.00 17.90 ? 129 PHE A CZ  1 
ATOM   996  N N   . PRO A 1 163 ? 11.524  -6.404  -31.533 1.00 18.98 ? 130 PRO A N   1 
ATOM   997  C CA  . PRO A 1 163 ? 12.198  -5.938  -32.751 1.00 23.42 ? 130 PRO A CA  1 
ATOM   998  C C   . PRO A 1 163 ? 13.467  -6.766  -32.992 1.00 24.06 ? 130 PRO A C   1 
ATOM   999  O O   . PRO A 1 163 ? 14.193  -6.985  -32.052 1.00 21.60 ? 130 PRO A O   1 
ATOM   1000 C CB  . PRO A 1 163 ? 12.541  -4.473  -32.445 1.00 24.13 ? 130 PRO A CB  1 
ATOM   1001 C CG  . PRO A 1 163 ? 11.543  -4.078  -31.345 1.00 22.80 ? 130 PRO A CG  1 
ATOM   1002 C CD  . PRO A 1 163 ? 11.336  -5.353  -30.543 1.00 24.07 ? 130 PRO A CD  1 
ATOM   1003 N N   . SER A 1 164 ? 13.684  -7.236  -34.215 1.00 23.59 ? 131 SER A N   1 
ATOM   1004 C CA  . SER A 1 164 ? 14.855  -8.080  -34.615 1.00 25.28 ? 131 SER A CA  1 
ATOM   1005 C C   . SER A 1 164 ? 16.175  -7.378  -34.274 1.00 23.30 ? 131 SER A C   1 
ATOM   1006 O O   . SER A 1 164 ? 17.149  -8.073  -33.994 1.00 28.32 ? 131 SER A O   1 
ATOM   1007 C CB  . SER A 1 164 ? 14.811  -8.418  -36.084 1.00 27.59 ? 131 SER A CB  1 
ATOM   1008 O OG  . SER A 1 164 ? 14.811  -7.194  -36.836 1.00 29.75 ? 131 SER A OG  1 
ATOM   1009 N N   . ASP A 1 165 ? 16.211  -6.057  -34.262 1.00 23.58 ? 132 ASP A N   1 
ATOM   1010 C CA  . ASP A 1 165 ? 17.450  -5.275  -34.003 1.00 29.57 ? 132 ASP A CA  1 
ATOM   1011 C C   . ASP A 1 165 ? 17.426  -4.702  -32.582 1.00 27.91 ? 132 ASP A C   1 
ATOM   1012 O O   . ASP A 1 165 ? 18.201  -3.746  -32.310 1.00 28.15 ? 132 ASP A O   1 
ATOM   1013 C CB  . ASP A 1 165 ? 17.590  -4.148  -35.030 1.00 30.71 ? 132 ASP A CB  1 
ATOM   1014 C CG  . ASP A 1 165 ? 16.403  -3.187  -35.068 1.00 39.48 ? 132 ASP A CG  1 
ATOM   1015 O OD1 . ASP A 1 165 ? 15.377  -3.436  -34.363 1.00 39.11 ? 132 ASP A OD1 1 
ATOM   1016 O OD2 . ASP A 1 165 ? 16.472  -2.226  -35.846 1.00 41.83 ? 132 ASP A OD2 1 
ATOM   1017 N N   . GLY A 1 166 ? 16.495  -5.164  -31.734 1.00 25.93 ? 133 GLY A N   1 
ATOM   1018 C CA  . GLY A 1 166 ? 16.322  -4.618  -30.376 1.00 25.05 ? 133 GLY A CA  1 
ATOM   1019 C C   . GLY A 1 166 ? 17.263  -5.333  -29.413 1.00 21.19 ? 133 GLY A C   1 
ATOM   1020 O O   . GLY A 1 166 ? 17.846  -6.352  -29.759 1.00 21.92 ? 133 GLY A O   1 
ATOM   1021 N N   . PRO A 1 167 ? 17.427  -4.818  -28.182 1.00 20.19 ? 134 PRO A N   1 
ATOM   1022 C CA  . PRO A 1 167 ? 18.389  -5.394  -27.244 1.00 20.04 ? 134 PRO A CA  1 
ATOM   1023 C C   . PRO A 1 167 ? 18.078  -6.833  -26.823 1.00 20.59 ? 134 PRO A C   1 
ATOM   1024 O O   . PRO A 1 167 ? 18.993  -7.561  -26.442 1.00 21.22 ? 134 PRO A O   1 
ATOM   1025 C CB  . PRO A 1 167 ? 18.330  -4.479  -26.024 1.00 21.59 ? 134 PRO A CB  1 
ATOM   1026 C CG  . PRO A 1 167 ? 17.092  -3.613  -26.178 1.00 22.79 ? 134 PRO A CG  1 
ATOM   1027 C CD  . PRO A 1 167 ? 16.776  -3.614  -27.656 1.00 20.65 ? 134 PRO A CD  1 
ATOM   1028 N N   . VAL A 1 168 ? 16.822  -7.244  -26.948 1.00 20.44 ? 135 VAL A N   1 
ATOM   1029 C CA  . VAL A 1 168 ? 16.435  -8.615  -26.570 1.00 19.78 ? 135 VAL A CA  1 
ATOM   1030 C C   . VAL A 1 168 ? 16.933  -9.575  -27.631 1.00 18.05 ? 135 VAL A C   1 
ATOM   1031 O O   . VAL A 1 168 ? 17.575  -10.581 -27.305 1.00 19.05 ? 135 VAL A O   1 
ATOM   1032 C CB  . VAL A 1 168 ? 14.922  -8.748  -26.284 1.00 19.56 ? 135 VAL A CB  1 
ATOM   1033 C CG1 . VAL A 1 168 ? 14.535  -10.198 -26.109 1.00 20.84 ? 135 VAL A CG1 1 
ATOM   1034 C CG2 . VAL A 1 168 ? 14.568  -7.948  -25.055 1.00 21.64 ? 135 VAL A CG2 1 
ATOM   1035 N N   . MET A 1 169 ? 16.611  -9.332  -28.892 1.00 19.63 ? 136 MET A N   1 
ATOM   1036 C CA  . MET A 1 169 ? 16.930  -10.345 -29.929 1.00 20.49 ? 136 MET A CA  1 
ATOM   1037 C C   . MET A 1 169 ? 18.432  -10.263 -30.279 1.00 20.20 ? 136 MET A C   1 
ATOM   1038 O O   . MET A 1 169 ? 18.979  -11.197 -30.806 1.00 21.82 ? 136 MET A O   1 
ATOM   1039 C CB  . MET A 1 169 ? 16.041  -10.137 -31.164 1.00 22.34 ? 136 MET A CB  1 
ATOM   1040 C CG  . MET A 1 169 ? 14.541  -10.303 -30.834 1.00 21.98 ? 136 MET A CG  1 
ATOM   1041 S SD  . MET A 1 169 ? 14.130  -11.887 -30.048 1.00 22.75 ? 136 MET A SD  1 
ATOM   1042 C CE  . MET A 1 169 ? 14.752  -13.121 -31.192 1.00 23.13 ? 136 MET A CE  1 
ATOM   1043 N N   . GLN A 1 170 ? 19.069  -9.164  -29.946 1.00 23.06 ? 137 GLN A N   1 
ATOM   1044 C CA  . GLN A 1 170 ? 20.509  -8.967  -30.237 1.00 25.49 ? 137 GLN A CA  1 
ATOM   1045 C C   . GLN A 1 170 ? 21.338  -9.308  -28.984 1.00 23.65 ? 137 GLN A C   1 
ATOM   1046 O O   . GLN A 1 170 ? 22.589  -9.131  -29.048 1.00 23.70 ? 137 GLN A O   1 
ATOM   1047 C CB  . GLN A 1 170 ? 20.736  -7.527  -30.705 1.00 23.05 ? 137 GLN A CB  1 
ATOM   1048 C CG  . GLN A 1 170 ? 20.200  -7.180  -32.111 1.00 28.83 ? 137 GLN A CG  1 
ATOM   1049 C CD  . GLN A 1 170 ? 20.694  -8.089  -33.223 1.00 30.99 ? 137 GLN A CD  1 
ATOM   1050 O OE1 . GLN A 1 170 ? 19.925  -8.652  -34.009 1.00 36.43 ? 137 GLN A OE1 1 
ATOM   1051 N NE2 . GLN A 1 170 ? 21.995  -8.313  -33.275 1.00 33.62 ? 137 GLN A NE2 1 
ATOM   1052 N N   . LYS A 1 171 ? 20.705  -9.776  -27.893 1.00 21.64 ? 138 LYS A N   1 
ATOM   1053 C CA  . LYS A 1 171 ? 21.440  -10.214 -26.672 1.00 20.60 ? 138 LYS A CA  1 
ATOM   1054 C C   . LYS A 1 171 ? 22.347  -9.073  -26.184 1.00 21.74 ? 138 LYS A C   1 
ATOM   1055 O O   . LYS A 1 171 ? 23.538  -9.346  -25.892 1.00 23.42 ? 138 LYS A O   1 
ATOM   1056 C CB  . LYS A 1 171 ? 22.210  -11.513 -26.952 1.00 24.65 ? 138 LYS A CB  1 
ATOM   1057 C CG  . LYS A 1 171 ? 21.381  -12.775 -27.120 1.00 25.15 ? 138 LYS A CG  1 
ATOM   1058 C CD  . LYS A 1 171 ? 21.878  -13.634 -28.249 1.00 33.45 ? 138 LYS A CD  1 
ATOM   1059 C CE  . LYS A 1 171 ? 21.630  -15.110 -28.071 1.00 37.59 ? 138 LYS A CE  1 
ATOM   1060 N NZ  . LYS A 1 171 ? 22.863  -15.782 -27.594 1.00 44.19 ? 138 LYS A NZ  1 
ATOM   1061 N N   . LYS A 1 172 ? 21.810  -7.851  -26.004 1.00 21.21 ? 139 LYS A N   1 
ATOM   1062 C CA  . LYS A 1 172 ? 22.570  -6.636  -25.560 1.00 23.45 ? 139 LYS A CA  1 
ATOM   1063 C C   . LYS A 1 172 ? 22.069  -6.142  -24.204 1.00 21.32 ? 139 LYS A C   1 
ATOM   1064 O O   . LYS A 1 172 ? 22.253  -4.959  -23.941 1.00 21.72 ? 139 LYS A O   1 
ATOM   1065 C CB  . LYS A 1 172 ? 22.533  -5.559  -26.648 1.00 26.13 ? 139 LYS A CB  1 
ATOM   1066 C CG  . LYS A 1 172 ? 23.057  -6.056  -27.997 1.00 27.00 ? 139 LYS A CG  1 
ATOM   1067 C CD  . LYS A 1 172 ? 24.443  -5.583  -28.466 1.00 31.89 ? 139 LYS A CD  1 
ATOM   1068 N N   . THR A 1 173 ? 21.470  -7.013  -23.372 1.00 18.86 ? 140 THR A N   1 
ATOM   1069 C CA  . THR A 1 173 ? 20.988  -6.671  -22.008 1.00 18.58 ? 140 THR A CA  1 
ATOM   1070 C C   . THR A 1 173 ? 22.057  -7.130  -21.008 1.00 17.28 ? 140 THR A C   1 
ATOM   1071 O O   . THR A 1 173 ? 22.889  -7.935  -21.355 1.00 21.38 ? 140 THR A O   1 
ATOM   1072 C CB  . THR A 1 173 ? 19.575  -7.238  -21.728 1.00 18.04 ? 140 THR A CB  1 
ATOM   1073 O OG1 . THR A 1 173 ? 19.632  -8.668  -21.692 1.00 19.33 ? 140 THR A OG1 1 
ATOM   1074 C CG2 . THR A 1 173 ? 18.579  -6.757  -22.770 1.00 21.69 ? 140 THR A CG2 1 
ATOM   1075 N N   . MET A 1 174 ? 22.005  -6.645  -19.791 1.00 20.43 ? 141 MET A N   1 
ATOM   1076 C CA  . MET A 1 174 ? 23.041  -6.919  -18.770 1.00 22.45 ? 141 MET A CA  1 
ATOM   1077 C C   . MET A 1 174 ? 22.399  -6.893  -17.386 1.00 20.74 ? 141 MET A C   1 
ATOM   1078 O O   . MET A 1 174 ? 22.890  -6.178  -16.483 1.00 19.50 ? 141 MET A O   1 
ATOM   1079 C CB  . MET A 1 174 ? 24.146  -5.867  -18.882 1.00 28.51 ? 141 MET A CB  1 
ATOM   1080 C CG  . MET A 1 174 ? 25.514  -6.416  -18.559 1.00 36.47 ? 141 MET A CG  1 
ATOM   1081 S SD  . MET A 1 174 ? 26.730  -5.040  -18.585 1.00 43.79 ? 141 MET A SD  1 
ATOM   1082 C CE  . MET A 1 174 ? 25.985  -3.889  -19.735 1.00 34.63 ? 141 MET A CE  1 
ATOM   1083 N N   . GLY A 1 175 ? 21.246  -7.561  -17.245 1.00 20.55 ? 142 GLY A N   1 
ATOM   1084 C CA  . GLY A 1 175 ? 20.631  -7.829  -15.927 1.00 20.79 ? 142 GLY A CA  1 
ATOM   1085 C C   . GLY A 1 175 ? 19.641  -6.763  -15.452 1.00 18.95 ? 142 GLY A C   1 
ATOM   1086 O O   . GLY A 1 175 ? 19.600  -5.646  -15.949 1.00 21.65 ? 142 GLY A O   1 
ATOM   1087 N N   . TRP A 1 176 ? 18.820  -7.118  -14.477 1.00 18.89 ? 143 TRP A N   1 
ATOM   1088 C CA  . TRP A 1 176 ? 17.751  -6.224  -13.977 1.00 18.90 ? 143 TRP A CA  1 
ATOM   1089 C C   . TRP A 1 176 ? 18.250  -5.298  -12.865 1.00 18.34 ? 143 TRP A C   1 
ATOM   1090 O O   . TRP A 1 176 ? 18.891  -5.827  -11.908 1.00 20.05 ? 143 TRP A O   1 
ATOM   1091 C CB  . TRP A 1 176 ? 16.585  -7.071  -13.474 1.00 17.86 ? 143 TRP A CB  1 
ATOM   1092 C CG  . TRP A 1 176 ? 15.924  -7.851  -14.562 1.00 16.61 ? 143 TRP A CG  1 
ATOM   1093 C CD1 . TRP A 1 176 ? 16.132  -9.155  -14.884 1.00 14.72 ? 143 TRP A CD1 1 
ATOM   1094 C CD2 . TRP A 1 176 ? 14.963  -7.334  -15.500 1.00 15.40 ? 143 TRP A CD2 1 
ATOM   1095 N NE1 . TRP A 1 176 ? 15.331  -9.488  -15.934 1.00 16.58 ? 143 TRP A NE1 1 
ATOM   1096 C CE2 . TRP A 1 176 ? 14.582  -8.408  -16.324 1.00 15.44 ? 143 TRP A CE2 1 
ATOM   1097 C CE3 . TRP A 1 176 ? 14.288  -6.121  -15.625 1.00 14.28 ? 143 TRP A CE3 1 
ATOM   1098 C CZ2 . TRP A 1 176 ? 13.621  -8.282  -17.317 1.00 15.40 ? 143 TRP A CZ2 1 
ATOM   1099 C CZ3 . TRP A 1 176 ? 13.397  -5.962  -16.672 1.00 16.35 ? 143 TRP A CZ3 1 
ATOM   1100 C CH2 . TRP A 1 176 ? 13.087  -7.027  -17.515 1.00 16.58 ? 143 TRP A CH2 1 
ATOM   1101 N N   . GLU A 1 177 ? 17.856  -4.020  -12.879 1.00 18.32 ? 144 GLU A N   1 
ATOM   1102 C CA  . GLU A 1 177 ? 17.901  -3.216  -11.642 1.00 21.27 ? 144 GLU A CA  1 
ATOM   1103 C C   . GLU A 1 177 ? 16.949  -3.816  -10.592 1.00 21.00 ? 144 GLU A C   1 
ATOM   1104 O O   . GLU A 1 177 ? 15.985  -4.498  -10.979 1.00 17.83 ? 144 GLU A O   1 
ATOM   1105 C CB  . GLU A 1 177 ? 17.527  -1.751  -11.869 1.00 23.10 ? 144 GLU A CB  1 
ATOM   1106 C CG  . GLU A 1 177 ? 18.434  -1.119  -12.910 1.00 28.11 ? 144 GLU A CG  1 
ATOM   1107 C CD  . GLU A 1 177 ? 19.720  -0.516  -12.379 1.00 38.00 ? 144 GLU A CD  1 
ATOM   1108 O OE1 . GLU A 1 177 ? 20.391  -1.099  -11.450 1.00 42.44 ? 144 GLU A OE1 1 
ATOM   1109 O OE2 . GLU A 1 177 ? 20.046  0.552   -12.896 1.00 46.33 ? 144 GLU A OE2 1 
ATOM   1110 N N   . ALA A 1 178 ? 17.238  -3.556  -9.312  1.00 18.93 ? 145 ALA A N   1 
ATOM   1111 C CA  . ALA A 1 178 ? 16.330  -3.891  -8.216  1.00 19.55 ? 145 ALA A CA  1 
ATOM   1112 C C   . ALA A 1 178 ? 14.968  -3.302  -8.536  1.00 20.76 ? 145 ALA A C   1 
ATOM   1113 O O   . ALA A 1 178 ? 14.898  -2.223  -9.179  1.00 21.09 ? 145 ALA A O   1 
ATOM   1114 C CB  . ALA A 1 178 ? 16.905  -3.344  -6.931  1.00 21.38 ? 145 ALA A CB  1 
ATOM   1115 N N   . SER A 1 179 ? 13.919  -4.055  -8.214  1.00 21.26 ? 146 SER A N   1 
ATOM   1116 C CA  . SER A 1 179 ? 12.509  -3.742  -8.522  1.00 17.07 ? 146 SER A CA  1 
ATOM   1117 C C   . SER A 1 179 ? 11.790  -3.614  -7.196  1.00 18.07 ? 146 SER A C   1 
ATOM   1118 O O   . SER A 1 179 ? 12.251  -4.169  -6.164  1.00 17.06 ? 146 SER A O   1 
ATOM   1119 C CB  . SER A 1 179 ? 11.839  -4.801  -9.358  1.00 17.13 ? 146 SER A CB  1 
ATOM   1120 O OG  . SER A 1 179 ? 12.430  -4.981  -10.640 1.00 18.16 ? 146 SER A OG  1 
ATOM   1121 N N   . SER A 1 180 ? 10.719  -2.839  -7.193  1.00 17.32 ? 147 SER A N   1 
ATOM   1122 C CA  . SER A 1 180 ? 9.838   -2.718  -6.019  1.00 18.38 ? 147 SER A CA  1 
ATOM   1123 C C   . SER A 1 180 ? 8.402   -2.933  -6.497  1.00 18.02 ? 147 SER A C   1 
ATOM   1124 O O   . SER A 1 180 ? 7.838   -2.074  -7.210  1.00 18.77 ? 147 SER A O   1 
ATOM   1125 C CB  . SER A 1 180 ? 10.073  -1.427  -5.255  1.00 20.12 ? 147 SER A CB  1 
ATOM   1126 O OG  . SER A 1 180 ? 9.280   -1.418  -4.090  1.00 24.18 ? 147 SER A OG  1 
ATOM   1127 N N   . GLU A 1 181 ? 7.855   -4.114  -6.194  1.00 16.62 ? 148 GLU A N   1 
ATOM   1128 C CA  . GLU A 1 181 ? 6.536   -4.534  -6.683  1.00 16.09 ? 148 GLU A CA  1 
ATOM   1129 C C   . GLU A 1 181 ? 5.473   -3.999  -5.736  1.00 17.27 ? 148 GLU A C   1 
ATOM   1130 O O   . GLU A 1 181 ? 5.528   -4.279  -4.531  1.00 16.46 ? 148 GLU A O   1 
ATOM   1131 C CB  . GLU A 1 181 ? 6.470   -6.057  -6.817  1.00 16.29 ? 148 GLU A CB  1 
ATOM   1132 C CG  . GLU A 1 181 ? 5.321   -6.531  -7.732  1.00 14.95 ? 148 GLU A CG  1 
ATOM   1133 C CD  . GLU A 1 181 ? 5.261   -8.058  -7.814  1.00 14.35 ? 148 GLU A CD  1 
ATOM   1134 O OE1 . GLU A 1 181 ? 6.135   -8.659  -7.224  1.00 16.68 ? 148 GLU A OE1 1 
ATOM   1135 O OE2 . GLU A 1 181 ? 4.467   -8.611  -8.527  1.00 14.28 ? 148 GLU A OE2 1 
ATOM   1136 N N   . ARG A 1 182 ? 4.489   -3.305  -6.284  1.00 16.10 ? 149 ARG A N   1 
ATOM   1137 C CA  . ARG A 1 182 ? 3.324   -2.789  -5.535  1.00 15.32 ? 149 ARG A CA  1 
ATOM   1138 C C   . ARG A 1 182 ? 2.277   -3.891  -5.442  1.00 15.24 ? 149 ARG A C   1 
ATOM   1139 O O   . ARG A 1 182 ? 1.779   -4.306  -6.482  1.00 13.75 ? 149 ARG A O   1 
ATOM   1140 C CB  . ARG A 1 182 ? 2.750   -1.560  -6.254  1.00 19.21 ? 149 ARG A CB  1 
ATOM   1141 C CG  . ARG A 1 182 ? 1.637   -0.887  -5.467  1.00 21.70 ? 149 ARG A CG  1 
ATOM   1142 C CD  . ARG A 1 182 ? 1.096   0.410   -6.047  1.00 25.67 ? 149 ARG A CD  1 
ATOM   1143 N NE  . ARG A 1 182 ? 0.271   0.181   -7.243  1.00 28.09 ? 149 ARG A NE  1 
ATOM   1144 C CZ  . ARG A 1 182 ? -1.010  -0.170  -7.193  1.00 32.72 ? 149 ARG A CZ  1 
ATOM   1145 N NH1 . ARG A 1 182 ? -1.589  -0.358  -6.013  1.00 32.58 ? 149 ARG A NH1 1 
ATOM   1146 N NH2 . ARG A 1 182 ? -1.719  -0.309  -8.310  1.00 36.62 ? 149 ARG A NH2 1 
ATOM   1147 N N   . MET A 1 183 ? 2.071   -4.420  -4.247  1.00 14.64 ? 150 MET A N   1 
ATOM   1148 C CA  . MET A 1 183 ? 1.164   -5.560  -4.015  1.00 16.28 ? 150 MET A CA  1 
ATOM   1149 C C   . MET A 1 183 ? -0.204  -5.051  -3.533  1.00 16.72 ? 150 MET A C   1 
ATOM   1150 O O   . MET A 1 183 ? -0.259  -4.181  -2.672  1.00 17.48 ? 150 MET A O   1 
ATOM   1151 C CB  . MET A 1 183 ? 1.766   -6.496  -2.984  1.00 15.22 ? 150 MET A CB  1 
ATOM   1152 C CG  . MET A 1 183 ? 3.255   -6.832  -3.175  1.00 14.88 ? 150 MET A CG  1 
ATOM   1153 S SD  . MET A 1 183 ? 3.653   -7.674  -4.727  1.00 15.68 ? 150 MET A SD  1 
ATOM   1154 C CE  . MET A 1 183 ? 2.720   -9.197  -4.603  1.00 17.52 ? 150 MET A CE  1 
ATOM   1155 N N   . TYR A 1 184 ? -1.296  -5.630  -4.031  1.00 17.48 ? 151 TYR A N   1 
ATOM   1156 C CA  . TYR A 1 184 ? -2.628  -5.201  -3.534  1.00 16.93 ? 151 TYR A CA  1 
ATOM   1157 C C   . TYR A 1 184 ? -3.659  -6.287  -3.778  1.00 15.74 ? 151 TYR A C   1 
ATOM   1158 O O   . TYR A 1 184 ? -3.597  -7.009  -4.758  1.00 15.41 ? 151 TYR A O   1 
ATOM   1159 C CB  . TYR A 1 184 ? -2.995  -3.857  -4.129  1.00 17.54 ? 151 TYR A CB  1 
ATOM   1160 C CG  . TYR A 1 184 ? -3.044  -3.844  -5.624  1.00 16.68 ? 151 TYR A CG  1 
ATOM   1161 C CD1 . TYR A 1 184 ? -1.898  -3.644  -6.364  1.00 21.64 ? 151 TYR A CD1 1 
ATOM   1162 C CD2 . TYR A 1 184 ? -4.231  -4.058  -6.303  1.00 17.49 ? 151 TYR A CD2 1 
ATOM   1163 C CE1 . TYR A 1 184 ? -1.919  -3.611  -7.751  1.00 22.06 ? 151 TYR A CE1 1 
ATOM   1164 C CE2 . TYR A 1 184 ? -4.276  -4.005  -7.694  1.00 19.23 ? 151 TYR A CE2 1 
ATOM   1165 C CZ  . TYR A 1 184 ? -3.105  -3.846  -8.421  1.00 22.60 ? 151 TYR A CZ  1 
ATOM   1166 O OH  . TYR A 1 184 ? -3.073  -3.781  -9.788  1.00 22.80 ? 151 TYR A OH  1 
ATOM   1167 N N   . PRO A 1 185 ? -4.618  -6.452  -2.876  1.00 15.06 ? 152 PRO A N   1 
ATOM   1168 C CA  . PRO A 1 185 ? -5.689  -7.434  -3.120  1.00 15.02 ? 152 PRO A CA  1 
ATOM   1169 C C   . PRO A 1 185 ? -6.695  -6.840  -4.096  1.00 16.27 ? 152 PRO A C   1 
ATOM   1170 O O   . PRO A 1 185 ? -6.967  -5.631  -4.030  1.00 15.78 ? 152 PRO A O   1 
ATOM   1171 C CB  . PRO A 1 185 ? -6.320  -7.630  -1.744  1.00 15.28 ? 152 PRO A CB  1 
ATOM   1172 C CG  . PRO A 1 185 ? -6.057  -6.285  -1.055  1.00 15.07 ? 152 PRO A CG  1 
ATOM   1173 C CD  . PRO A 1 185 ? -4.745  -5.752  -1.591  1.00 15.61 ? 152 PRO A CD  1 
ATOM   1174 N N   . GLU A 1 186 ? -7.174  -7.663  -5.005  1.00 16.21 ? 153 GLU A N   1 
ATOM   1175 C CA  . GLU A 1 186 ? -8.206  -7.251  -5.971  1.00 17.11 ? 153 GLU A CA  1 
ATOM   1176 C C   . GLU A 1 186 ? -8.929  -8.475  -6.499  1.00 16.62 ? 153 GLU A C   1 
ATOM   1177 O O   . GLU A 1 186 ? -8.251  -9.431  -6.906  1.00 16.60 ? 153 GLU A O   1 
ATOM   1178 C CB  . GLU A 1 186 ? -7.587  -6.494  -7.139  1.00 18.46 ? 153 GLU A CB  1 
ATOM   1179 C CG  . GLU A 1 186 ? -8.574  -5.656  -7.945  1.00 20.34 ? 153 GLU A CG  1 
ATOM   1180 C CD  . GLU A 1 186 ? -7.875  -4.857  -9.017  1.00 23.90 ? 153 GLU A CD  1 
ATOM   1181 O OE1 . GLU A 1 186 ? -7.221  -5.468  -9.845  1.00 30.35 ? 153 GLU A OE1 1 
ATOM   1182 O OE2 . GLU A 1 186 ? -7.988  -3.648  -9.014  1.00 28.35 ? 153 GLU A OE2 1 
ATOM   1183 N N   . ASP A 1 187 ? -10.247 -8.416  -6.512  1.00 18.71 ? 154 ASP A N   1 
ATOM   1184 C CA  . ASP A 1 187 ? -11.115 -9.442  -7.165  1.00 21.39 ? 154 ASP A CA  1 
ATOM   1185 C C   . ASP A 1 187 ? -10.790 -10.799 -6.538  1.00 19.72 ? 154 ASP A C   1 
ATOM   1186 O O   . ASP A 1 187 ? -10.825 -11.789 -7.247  1.00 19.69 ? 154 ASP A O   1 
ATOM   1187 C CB  . ASP A 1 187 ? -10.898 -9.553  -8.680  1.00 24.45 ? 154 ASP A CB  1 
ATOM   1188 C CG  . ASP A 1 187 ? -10.939 -8.266  -9.482  1.00 29.59 ? 154 ASP A CG  1 
ATOM   1189 O OD1 . ASP A 1 187 ? -11.972 -7.582  -9.356  1.00 27.57 ? 154 ASP A OD1 1 
ATOM   1190 O OD2 . ASP A 1 187 ? -9.961  -7.997  -10.306 1.00 31.72 ? 154 ASP A OD2 1 
ATOM   1191 N N   . GLY A 1 188 ? -10.449 -10.853 -5.255  1.00 16.55 ? 155 GLY A N   1 
ATOM   1192 C CA  . GLY A 1 188 ? -10.245 -12.168 -4.616  1.00 15.71 ? 155 GLY A CA  1 
ATOM   1193 C C   . GLY A 1 188 ? -8.867  -12.748 -4.904  1.00 13.91 ? 155 GLY A C   1 
ATOM   1194 O O   . GLY A 1 188 ? -8.628  -13.948 -4.700  1.00 14.31 ? 155 GLY A O   1 
ATOM   1195 N N   . ALA A 1 189 ? -7.963  -11.973 -5.430  1.00 12.81 ? 156 ALA A N   1 
ATOM   1196 C CA  . ALA A 1 189 ? -6.601  -12.451 -5.743  1.00 13.97 ? 156 ALA A CA  1 
ATOM   1197 C C   . ALA A 1 189 ? -5.558  -11.449 -5.254  1.00 14.52 ? 156 ALA A C   1 
ATOM   1198 O O   . ALA A 1 189 ? -5.956  -10.319 -4.814  1.00 13.33 ? 156 ALA A O   1 
ATOM   1199 C CB  . ALA A 1 189 ? -6.493  -12.631 -7.249  1.00 16.43 ? 156 ALA A CB  1 
ATOM   1200 N N   . LEU A 1 190 ? -4.289  -11.816 -5.379  1.00 12.68 ? 157 LEU A N   1 
ATOM   1201 C CA  . LEU A 1 190 ? -3.191  -10.893 -5.011  1.00 13.36 ? 157 LEU A CA  1 
ATOM   1202 C C   . LEU A 1 190 ? -2.581  -10.374 -6.306  1.00 15.62 ? 157 LEU A C   1 
ATOM   1203 O O   . LEU A 1 190 ? -2.262  -11.175 -7.165  1.00 15.12 ? 157 LEU A O   1 
ATOM   1204 C CB  . LEU A 1 190 ? -2.179  -11.568 -4.081  1.00 14.12 ? 157 LEU A CB  1 
ATOM   1205 C CG  . LEU A 1 190 ? -0.924  -10.751 -3.753  1.00 15.62 ? 157 LEU A CG  1 
ATOM   1206 C CD1 . LEU A 1 190 ? -1.350  -9.478  -3.024  1.00 16.92 ? 157 LEU A CD1 1 
ATOM   1207 C CD2 . LEU A 1 190 ? 0.077   -11.536 -2.915  1.00 14.71 ? 157 LEU A CD2 1 
ATOM   1208 N N   . LYS A 1 191 ? -2.517  -9.045  -6.479  1.00 14.55 ? 158 LYS A N   1 
ATOM   1209 C CA  . LYS A 1 191 ? -1.993  -8.392  -7.700  1.00 16.63 ? 158 LYS A CA  1 
ATOM   1210 C C   . LYS A 1 191 ? -0.663  -7.710  -7.387  1.00 15.29 ? 158 LYS A C   1 
ATOM   1211 O O   . LYS A 1 191 ? -0.445  -7.282  -6.231  1.00 14.37 ? 158 LYS A O   1 
ATOM   1212 C CB  . LYS A 1 191 ? -3.017  -7.396  -8.240  1.00 19.06 ? 158 LYS A CB  1 
ATOM   1213 C CG  . LYS A 1 191 ? -4.174  -8.057  -8.986  1.00 22.62 ? 158 LYS A CG  1 
ATOM   1214 C CD  . LYS A 1 191 ? -4.572  -7.234  -10.206 1.00 30.38 ? 158 LYS A CD  1 
ATOM   1215 C CE  . LYS A 1 191 ? -5.748  -7.764  -11.014 1.00 35.15 ? 158 LYS A CE  1 
ATOM   1216 N NZ  . LYS A 1 191 ? -6.730  -8.400  -10.115 1.00 37.44 ? 158 LYS A NZ  1 
ATOM   1217 N N   . GLY A 1 192 ? 0.258   -7.711  -8.365  1.00 13.87 ? 159 GLY A N   1 
ATOM   1218 C CA  . GLY A 1 192 ? 1.498   -6.934  -8.260  1.00 13.62 ? 159 GLY A CA  1 
ATOM   1219 C C   . GLY A 1 192 ? 1.691   -6.146  -9.535  1.00 13.66 ? 159 GLY A C   1 
ATOM   1220 O O   . GLY A 1 192 ? 1.363   -6.620  -10.618 1.00 12.35 ? 159 GLY A O   1 
ATOM   1221 N N   . GLU A 1 193 ? 2.179   -4.922  -9.397  1.00 15.17 ? 160 GLU A N   1 
ATOM   1222 C CA  . GLU A 1 193 ? 2.443   -3.996  -10.521 1.00 17.77 ? 160 GLU A CA  1 
ATOM   1223 C C   . GLU A 1 193 ? 3.777   -3.294  -10.274 1.00 16.68 ? 160 GLU A C   1 
ATOM   1224 O O   . GLU A 1 193 ? 4.081   -2.929  -9.109  1.00 16.61 ? 160 GLU A O   1 
ATOM   1225 C CB  . GLU A 1 193 ? 1.255   -3.036  -10.599 1.00 22.89 ? 160 GLU A CB  1 
ATOM   1226 C CG  . GLU A 1 193 ? 1.535   -1.713  -11.212 1.00 31.50 ? 160 GLU A CG  1 
ATOM   1227 C CD  . GLU A 1 193 ? 0.208   -0.982  -11.198 1.00 40.08 ? 160 GLU A CD  1 
ATOM   1228 O OE1 . GLU A 1 193 ? -0.657  -1.353  -12.025 1.00 51.54 ? 160 GLU A OE1 1 
ATOM   1229 O OE2 . GLU A 1 193 ? 0.013   -0.129  -10.289 1.00 54.31 ? 160 GLU A OE2 1 
ATOM   1230 N N   . MET A 1 194 ? 4.575   -3.189  -11.316 1.00 18.05 ? 161 MET A N   1 
ATOM   1231 C CA  . MET A 1 194 ? 5.874   -2.498  -11.231 1.00 19.44 ? 161 MET A CA  1 
ATOM   1232 C C   . MET A 1 194 ? 6.403   -2.189  -12.610 1.00 20.84 ? 161 MET A C   1 
ATOM   1233 O O   . MET A 1 194 ? 6.053   -2.886  -13.547 1.00 18.17 ? 161 MET A O   1 
ATOM   1234 C CB  . MET A 1 194 ? 6.937   -3.343  -10.545 1.00 21.43 ? 161 MET A CB  1 
ATOM   1235 C CG  . MET A 1 194 ? 7.157   -4.710  -11.227 1.00 22.63 ? 161 MET A CG  1 
ATOM   1236 S SD  . MET A 1 194 ? 8.092   -5.787  -10.104 1.00 25.51 ? 161 MET A SD  1 
ATOM   1237 C CE  . MET A 1 194 ? 7.629   -7.412  -10.691 1.00 22.84 ? 161 MET A CE  1 
ATOM   1238 N N   . LYS A 1 195 ? 7.315   -1.220  -12.643 1.00 19.11 ? 162 LYS A N   1 
ATOM   1239 C CA  . LYS A 1 195 ? 8.127   -0.950  -13.829 1.00 21.36 ? 162 LYS A CA  1 
ATOM   1240 C C   . LYS A 1 195 ? 9.464   -1.658  -13.614 1.00 19.85 ? 162 LYS A C   1 
ATOM   1241 O O   . LYS A 1 195 ? 10.089  -1.445  -12.593 1.00 22.70 ? 162 LYS A O   1 
ATOM   1242 C CB  . LYS A 1 195 ? 8.276   0.554   -14.076 1.00 24.10 ? 162 LYS A CB  1 
ATOM   1243 C CG  . LYS A 1 195 ? 9.060   0.814   -15.356 1.00 28.54 ? 162 LYS A CG  1 
ATOM   1244 C CD  . LYS A 1 195 ? 9.627   2.220   -15.530 1.00 34.27 ? 162 LYS A CD  1 
ATOM   1245 C CE  . LYS A 1 195 ? 9.280   2.760   -16.903 1.00 40.38 ? 162 LYS A CE  1 
ATOM   1246 N NZ  . LYS A 1 195 ? 10.131  3.920   -17.288 1.00 47.07 ? 162 LYS A NZ  1 
ATOM   1247 N N   . MET A 1 196 ? 9.821   -2.610  -14.451 1.00 16.61 ? 163 MET A N   1 
ATOM   1248 C CA  . MET A 1 196 ? 11.137  -3.242  -14.266 1.00 17.43 ? 163 MET A CA  1 
ATOM   1249 C C   . MET A 1 196 ? 12.122  -2.611  -15.251 1.00 17.44 ? 163 MET A C   1 
ATOM   1250 O O   . MET A 1 196 ? 11.705  -2.346  -16.413 1.00 17.62 ? 163 MET A O   1 
ATOM   1251 C CB  . MET A 1 196 ? 11.015  -4.747  -14.510 1.00 16.50 ? 163 MET A CB  1 
ATOM   1252 C CG  . MET A 1 196 ? 10.186  -5.440  -13.450 1.00 18.06 ? 163 MET A CG  1 
ATOM   1253 S SD  . MET A 1 196 ? 9.993   -7.255  -13.734 1.00 17.18 ? 163 MET A SD  1 
ATOM   1254 C CE  . MET A 1 196 ? 11.713  -7.757  -13.728 1.00 18.54 ? 163 MET A CE  1 
ATOM   1255 N N   . ARG A 1 197 ? 13.383  -2.480  -14.853 1.00 18.57 ? 164 ARG A N   1 
ATOM   1256 C CA  . ARG A 1 197 ? 14.387  -1.803  -15.694 1.00 21.83 ? 164 ARG A CA  1 
ATOM   1257 C C   . ARG A 1 197 ? 15.520  -2.742  -16.041 1.00 19.41 ? 164 ARG A C   1 
ATOM   1258 O O   . ARG A 1 197 ? 16.219  -3.167  -15.080 1.00 16.98 ? 164 ARG A O   1 
ATOM   1259 C CB  . ARG A 1 197 ? 15.061  -0.654  -14.957 1.00 24.79 ? 164 ARG A CB  1 
ATOM   1260 C CG  . ARG A 1 197 ? 14.314  0.656   -14.927 1.00 32.70 ? 164 ARG A CG  1 
ATOM   1261 C CD  . ARG A 1 197 ? 15.361  1.765   -15.101 1.00 31.34 ? 164 ARG A CD  1 
ATOM   1262 N NE  . ARG A 1 197 ? 14.748  2.629   -16.073 1.00 33.65 ? 164 ARG A NE  1 
ATOM   1263 C CZ  . ARG A 1 197 ? 14.822  3.947   -16.106 1.00 32.73 ? 164 ARG A CZ  1 
ATOM   1264 N NH1 . ARG A 1 197 ? 15.538  4.615   -15.221 1.00 29.62 ? 164 ARG A NH1 1 
ATOM   1265 N NH2 . ARG A 1 197 ? 14.118  4.587   -17.008 1.00 32.40 ? 164 ARG A NH2 1 
ATOM   1266 N N   . LEU A 1 198 ? 15.713  -3.053  -17.327 1.00 18.24 ? 165 LEU A N   1 
ATOM   1267 C CA  . LEU A 1 198 ? 16.880  -3.853  -17.776 1.00 21.48 ? 165 LEU A CA  1 
ATOM   1268 C C   . LEU A 1 198 ? 18.049  -2.913  -18.039 1.00 23.21 ? 165 LEU A C   1 
ATOM   1269 O O   . LEU A 1 198 ? 17.870  -1.861  -18.704 1.00 23.35 ? 165 LEU A O   1 
ATOM   1270 C CB  . LEU A 1 198 ? 16.587  -4.644  -19.052 1.00 22.70 ? 165 LEU A CB  1 
ATOM   1271 C CG  . LEU A 1 198 ? 16.377  -6.141  -18.888 1.00 26.47 ? 165 LEU A CG  1 
ATOM   1272 C CD1 . LEU A 1 198 ? 16.065  -6.780  -20.235 1.00 23.52 ? 165 LEU A CD1 1 
ATOM   1273 C CD2 . LEU A 1 198 ? 17.573  -6.790  -18.184 1.00 25.03 ? 165 LEU A CD2 1 
ATOM   1274 N N   . ARG A 1 199 ? 19.219  -3.285  -17.566 1.00 21.14 ? 166 ARG A N   1 
ATOM   1275 C CA  . ARG A 1 199 ? 20.456  -2.562  -17.965 1.00 23.48 ? 166 ARG A CA  1 
ATOM   1276 C C   . ARG A 1 199 ? 20.844  -3.020  -19.372 1.00 22.05 ? 166 ARG A C   1 
ATOM   1277 O O   . ARG A 1 199 ? 20.800  -4.245  -19.649 1.00 27.37 ? 166 ARG A O   1 
ATOM   1278 C CB  . ARG A 1 199 ? 21.603  -2.848  -17.000 1.00 22.25 ? 166 ARG A CB  1 
ATOM   1279 C CG  . ARG A 1 199 ? 21.338  -2.397  -15.568 1.00 25.13 ? 166 ARG A CG  1 
ATOM   1280 C CD  . ARG A 1 199 ? 22.475  -2.767  -14.629 1.00 29.13 ? 166 ARG A CD  1 
ATOM   1281 N NE  . ARG A 1 199 ? 22.594  -4.213  -14.382 1.00 32.78 ? 166 ARG A NE  1 
ATOM   1282 C CZ  . ARG A 1 199 ? 22.174  -4.839  -13.275 1.00 32.88 ? 166 ARG A CZ  1 
ATOM   1283 N NH1 . ARG A 1 199 ? 21.636  -4.162  -12.273 1.00 36.25 ? 166 ARG A NH1 1 
ATOM   1284 N NH2 . ARG A 1 199 ? 22.327  -6.148  -13.149 1.00 33.96 ? 166 ARG A NH2 1 
ATOM   1285 N N   . LEU A 1 200 ? 21.327  -2.112  -20.210 1.00 25.59 ? 167 LEU A N   1 
ATOM   1286 C CA  . LEU A 1 200 ? 21.909  -2.475  -21.527 1.00 28.79 ? 167 LEU A CA  1 
ATOM   1287 C C   . LEU A 1 200 ? 23.448  -2.470  -21.468 1.00 29.90 ? 167 LEU A C   1 
ATOM   1288 O O   . LEU A 1 200 ? 23.974  -1.705  -20.663 1.00 29.98 ? 167 LEU A O   1 
ATOM   1289 C CB  . LEU A 1 200 ? 21.417  -1.460  -22.548 1.00 28.94 ? 167 LEU A CB  1 
ATOM   1290 C CG  . LEU A 1 200 ? 19.909  -1.389  -22.721 1.00 29.89 ? 167 LEU A CG  1 
ATOM   1291 C CD1 . LEU A 1 200 ? 19.553  -0.159  -23.543 1.00 30.61 ? 167 LEU A CD1 1 
ATOM   1292 C CD2 . LEU A 1 200 ? 19.422  -2.671  -23.375 1.00 31.96 ? 167 LEU A CD2 1 
ATOM   1293 N N   . LYS A 1 201 ? 24.113  -3.330  -22.271 1.00 36.38 ? 168 LYS A N   1 
ATOM   1294 C CA  . LYS A 1 201 ? 25.577  -3.306  -22.600 1.00 40.68 ? 168 LYS A CA  1 
ATOM   1295 C C   . LYS A 1 201 ? 25.827  -2.096  -23.487 1.00 44.85 ? 168 LYS A C   1 
ATOM   1296 O O   . LYS A 1 201 ? 25.620  -2.211  -24.722 1.00 63.36 ? 168 LYS A O   1 
ATOM   1297 C CB  . LYS A 1 201 ? 26.077  -4.517  -23.407 1.00 42.43 ? 168 LYS A CB  1 
ATOM   1298 C CG  . LYS A 1 201 ? 25.661  -5.887  -22.903 1.00 45.77 ? 168 LYS A CG  1 
ATOM   1299 C CD  . LYS A 1 201 ? 26.073  -7.017  -23.811 1.00 45.42 ? 168 LYS A CD  1 
ATOM   1300 C CE  . LYS A 1 201 ? 25.331  -8.291  -23.439 1.00 46.93 ? 168 LYS A CE  1 
ATOM   1301 N NZ  . LYS A 1 201 ? 26.268  -9.405  -23.162 1.00 46.36 ? 168 LYS A NZ  1 
ATOM   1302 N N   . ASP A 1 202 ? 26.244  -0.972  -22.918 1.00 48.53 ? 169 ASP A N   1 
ATOM   1303 C CA  . ASP A 1 202 ? 25.911  0.303   -23.584 1.00 45.05 ? 169 ASP A CA  1 
ATOM   1304 C C   . ASP A 1 202 ? 25.894  1.358   -22.491 1.00 48.44 ? 169 ASP A C   1 
ATOM   1305 O O   . ASP A 1 202 ? 26.498  2.420   -22.682 1.00 64.93 ? 169 ASP A O   1 
ATOM   1306 C CB  . ASP A 1 202 ? 24.603  0.005   -24.317 1.00 51.57 ? 169 ASP A CB  1 
ATOM   1307 C CG  . ASP A 1 202 ? 23.657  1.126   -24.629 1.00 41.46 ? 169 ASP A CG  1 
ATOM   1308 O OD1 . ASP A 1 202 ? 23.091  1.688   -23.675 1.00 47.73 ? 169 ASP A OD1 1 
ATOM   1309 O OD2 . ASP A 1 202 ? 23.440  1.346   -25.836 1.00 43.73 ? 169 ASP A OD2 1 
ATOM   1310 N N   . GLY A 1 203 ? 25.270  1.042   -21.364 1.00 38.16 ? 170 GLY A N   1 
ATOM   1311 C CA  . GLY A 1 203 ? 25.235  1.965   -20.218 1.00 40.04 ? 170 GLY A CA  1 
ATOM   1312 C C   . GLY A 1 203 ? 23.870  2.590   -20.019 1.00 35.79 ? 170 GLY A C   1 
ATOM   1313 O O   . GLY A 1 203 ? 23.720  3.282   -19.013 1.00 44.07 ? 170 GLY A O   1 
ATOM   1314 N N   . GLY A 1 204 ? 22.898  2.323   -20.902 1.00 32.49 ? 171 GLY A N   1 
ATOM   1315 C CA  . GLY A 1 204 ? 21.514  2.826   -20.763 1.00 35.92 ? 171 GLY A CA  1 
ATOM   1316 C C   . GLY A 1 204 ? 20.547  1.794   -20.165 1.00 36.45 ? 171 GLY A C   1 
ATOM   1317 O O   . GLY A 1 204 ? 21.024  0.770   -19.611 1.00 27.54 ? 171 GLY A O   1 
ATOM   1318 N N   . HIS A 1 205 ? 19.228  2.044   -20.274 1.00 32.05 ? 172 HIS A N   1 
ATOM   1319 C CA  . HIS A 1 205 ? 18.157  1.247   -19.617 1.00 34.26 ? 172 HIS A CA  1 
ATOM   1320 C C   . HIS A 1 205 ? 17.086  0.873   -20.642 1.00 27.69 ? 172 HIS A C   1 
ATOM   1321 O O   . HIS A 1 205 ? 17.008  1.507   -21.659 1.00 23.80 ? 172 HIS A O   1 
ATOM   1322 C CB  . HIS A 1 205 ? 17.602  1.970   -18.383 1.00 40.36 ? 172 HIS A CB  1 
ATOM   1323 C CG  . HIS A 1 205 ? 18.527  1.895   -17.201 1.00 55.34 ? 172 HIS A CG  1 
ATOM   1324 N ND1 . HIS A 1 205 ? 19.290  2.984   -16.767 1.00 60.71 ? 172 HIS A ND1 1 
ATOM   1325 C CD2 . HIS A 1 205 ? 18.828  0.877   -16.349 1.00 62.25 ? 172 HIS A CD2 1 
ATOM   1326 C CE1 . HIS A 1 205 ? 20.009  2.632   -15.708 1.00 58.88 ? 172 HIS A CE1 1 
ATOM   1327 N NE2 . HIS A 1 205 ? 19.750  1.344   -15.435 1.00 58.64 ? 172 HIS A NE2 1 
ATOM   1328 N N   . TYR A 1 206 ? 16.358  -0.200  -20.397 1.00 22.03 ? 173 TYR A N   1 
ATOM   1329 C CA  . TYR A 1 206 ? 15.296  -0.726  -21.293 1.00 21.05 ? 173 TYR A CA  1 
ATOM   1330 C C   . TYR A 1 206 ? 14.149  -1.149  -20.387 1.00 22.58 ? 173 TYR A C   1 
ATOM   1331 O O   . TYR A 1 206 ? 14.368  -2.054  -19.555 1.00 23.42 ? 173 TYR A O   1 
ATOM   1332 C CB  . TYR A 1 206 ? 15.869  -1.871  -22.127 1.00 21.54 ? 173 TYR A CB  1 
ATOM   1333 C CG  . TYR A 1 206 ? 14.886  -2.657  -22.968 1.00 21.06 ? 173 TYR A CG  1 
ATOM   1334 C CD1 . TYR A 1 206 ? 14.116  -2.055  -23.963 1.00 21.04 ? 173 TYR A CD1 1 
ATOM   1335 C CD2 . TYR A 1 206 ? 14.713  -4.022  -22.775 1.00 19.00 ? 173 TYR A CD2 1 
ATOM   1336 C CE1 . TYR A 1 206 ? 13.242  -2.795  -24.748 1.00 18.96 ? 173 TYR A CE1 1 
ATOM   1337 C CE2 . TYR A 1 206 ? 13.812  -4.765  -23.532 1.00 20.64 ? 173 TYR A CE2 1 
ATOM   1338 C CZ  . TYR A 1 206 ? 13.083  -4.155  -24.544 1.00 20.07 ? 173 TYR A CZ  1 
ATOM   1339 O OH  . TYR A 1 206 ? 12.243  -4.927  -25.314 1.00 20.32 ? 173 TYR A OH  1 
ATOM   1340 N N   . ASP A 1 207 ? 13.015  -0.467  -20.456 1.00 20.36 ? 174 ASP A N   1 
ATOM   1341 C CA  . ASP A 1 207 ? 11.939  -0.686  -19.460 1.00 20.52 ? 174 ASP A CA  1 
ATOM   1342 C C   . ASP A 1 207 ? 10.812  -1.652  -19.896 1.00 20.77 ? 174 ASP A C   1 
ATOM   1343 O O   . ASP A 1 207 ? 10.467  -1.763  -21.111 1.00 20.97 ? 174 ASP A O   1 
ATOM   1344 C CB  . ASP A 1 207 ? 11.322  0.649   -19.101 1.00 22.48 ? 174 ASP A CB  1 
ATOM   1345 C CG  . ASP A 1 207 ? 12.310  1.538   -18.359 1.00 26.01 ? 174 ASP A CG  1 
ATOM   1346 O OD1 . ASP A 1 207 ? 13.373  1.037   -17.923 1.00 23.68 ? 174 ASP A OD1 1 
ATOM   1347 O OD2 . ASP A 1 207 ? 12.021  2.718   -18.257 1.00 26.55 ? 174 ASP A OD2 1 
ATOM   1348 N N   . ALA A 1 208 ? 10.144  -2.225  -18.892 1.00 17.81 ? 175 ALA A N   1 
ATOM   1349 C CA  . ALA A 1 208 ? 8.919   -3.008  -19.059 1.00 17.72 ? 175 ALA A CA  1 
ATOM   1350 C C   . ALA A 1 208 ? 7.943   -2.623  -17.964 1.00 17.13 ? 175 ALA A C   1 
ATOM   1351 O O   . ALA A 1 208 ? 8.396   -2.550  -16.762 1.00 15.99 ? 175 ALA A O   1 
ATOM   1352 C CB  . ALA A 1 208 ? 9.181   -4.492  -19.030 1.00 18.23 ? 175 ALA A CB  1 
ATOM   1353 N N   . GLU A 1 209 ? 6.662   -2.453  -18.341 1.00 16.34 ? 176 GLU A N   1 
ATOM   1354 C CA  . GLU A 1 209 ? 5.545   -2.351  -17.369 1.00 18.37 ? 176 GLU A CA  1 
ATOM   1355 C C   . GLU A 1 209 ? 5.034   -3.752  -17.109 1.00 17.93 ? 176 GLU A C   1 
ATOM   1356 O O   . GLU A 1 209 ? 4.692   -4.464  -18.053 1.00 18.26 ? 176 GLU A O   1 
ATOM   1357 C CB  . GLU A 1 209 ? 4.359   -1.514  -17.828 1.00 22.37 ? 176 GLU A CB  1 
ATOM   1358 C CG  . GLU A 1 209 ? 4.709   -0.032  -18.028 1.00 26.74 ? 176 GLU A CG  1 
ATOM   1359 C CD  . GLU A 1 209 ? 5.040   0.799   -16.796 1.00 31.15 ? 176 GLU A CD  1 
ATOM   1360 O OE1 . GLU A 1 209 ? 4.647   0.452   -15.651 1.00 33.79 ? 176 GLU A OE1 1 
ATOM   1361 O OE2 . GLU A 1 209 ? 5.718   1.800   -16.995 1.00 38.38 ? 176 GLU A OE2 1 
ATOM   1362 N N   . VAL A 1 210 ? 4.955   -4.104  -15.840 1.00 16.18 ? 177 VAL A N   1 
ATOM   1363 C CA  . VAL A 1 210 ? 4.729   -5.521  -15.433 1.00 15.55 ? 177 VAL A CA  1 
ATOM   1364 C C   . VAL A 1 210 ? 3.502   -5.630  -14.536 1.00 15.86 ? 177 VAL A C   1 
ATOM   1365 O O   . VAL A 1 210 ? 3.403   -4.874  -13.591 1.00 15.23 ? 177 VAL A O   1 
ATOM   1366 C CB  . VAL A 1 210 ? 5.990   -6.104  -14.783 1.00 15.88 ? 177 VAL A CB  1 
ATOM   1367 C CG1 . VAL A 1 210 ? 5.791   -7.583  -14.402 1.00 17.03 ? 177 VAL A CG1 1 
ATOM   1368 C CG2 . VAL A 1 210 ? 7.145   -5.973  -15.749 1.00 14.91 ? 177 VAL A CG2 1 
ATOM   1369 N N   . LYS A 1 211 ? 2.576   -6.506  -14.896 1.00 13.87 ? 178 LYS A N   1 
ATOM   1370 C CA  . LYS A 1 211 ? 1.369   -6.770  -14.091 1.00 14.36 ? 178 LYS A CA  1 
ATOM   1371 C C   . LYS A 1 211 ? 1.305   -8.278  -13.888 1.00 14.49 ? 178 LYS A C   1 
ATOM   1372 O O   . LYS A 1 211 ? 1.365   -9.032  -14.909 1.00 14.17 ? 178 LYS A O   1 
ATOM   1373 C CB  . LYS A 1 211 ? 0.073   -6.300  -14.761 1.00 15.44 ? 178 LYS A CB  1 
ATOM   1374 C CG  . LYS A 1 211 ? 0.094   -4.805  -15.110 1.00 16.42 ? 178 LYS A CG  1 
ATOM   1375 N N   . THR A 1 212 ? 1.104   -8.685  -12.626 1.00 13.83 ? 179 THR A N   1 
ATOM   1376 C CA  . THR A 1 212 ? 0.986   -10.127 -12.277 1.00 13.71 ? 179 THR A CA  1 
ATOM   1377 C C   . THR A 1 212 ? -0.257  -10.330 -11.405 1.00 14.27 ? 179 THR A C   1 
ATOM   1378 O O   . THR A 1 212 ? -0.523  -9.485  -10.532 1.00 13.97 ? 179 THR A O   1 
ATOM   1379 C CB  . THR A 1 212 ? 2.244   -10.638 -11.567 1.00 13.28 ? 179 THR A CB  1 
ATOM   1380 O OG1 . THR A 1 212 ? 3.412   -10.184 -12.259 1.00 14.28 ? 179 THR A OG1 1 
ATOM   1381 C CG2 . THR A 1 212 ? 2.268   -12.156 -11.496 1.00 12.97 ? 179 THR A CG2 1 
ATOM   1382 N N   . THR A 1 213 ? -0.919  -11.469 -11.548 1.00 15.05 ? 180 THR A N   1 
ATOM   1383 C CA  . THR A 1 213 ? -2.016  -11.907 -10.661 1.00 15.07 ? 180 THR A CA  1 
ATOM   1384 C C   . THR A 1 213 ? -1.556  -13.231 -10.043 1.00 14.87 ? 180 THR A C   1 
ATOM   1385 O O   . THR A 1 213 ? -1.080  -14.081 -10.830 1.00 15.84 ? 180 THR A O   1 
ATOM   1386 C CB  . THR A 1 213 ? -3.354  -11.974 -11.393 1.00 17.65 ? 180 THR A CB  1 
ATOM   1387 O OG1 . THR A 1 213 ? -3.650  -10.651 -11.839 1.00 20.06 ? 180 THR A OG1 1 
ATOM   1388 C CG2 . THR A 1 213 ? -4.475  -12.445 -10.507 1.00 20.17 ? 180 THR A CG2 1 
ATOM   1389 N N   . TYR A 1 214 ? -1.585  -13.327 -8.706  1.00 13.26 ? 181 TYR A N   1 
ATOM   1390 C CA  . TYR A 1 214 ? -1.179  -14.496 -7.909  1.00 13.24 ? 181 TYR A CA  1 
ATOM   1391 C C   . TYR A 1 214 ? -2.459  -15.016 -7.254  1.00 14.64 ? 181 TYR A C   1 
ATOM   1392 O O   . TYR A 1 214 ? -3.192  -14.247 -6.558  1.00 16.29 ? 181 TYR A O   1 
ATOM   1393 C CB  . TYR A 1 214 ? -0.116  -14.124 -6.864  1.00 13.52 ? 181 TYR A CB  1 
ATOM   1394 C CG  . TYR A 1 214 ? 1.092   -13.355 -7.375  1.00 12.39 ? 181 TYR A CG  1 
ATOM   1395 C CD1 . TYR A 1 214 ? 1.101   -11.967 -7.464  1.00 12.90 ? 181 TYR A CD1 1 
ATOM   1396 C CD2 . TYR A 1 214 ? 2.262   -13.995 -7.752  1.00 13.61 ? 181 TYR A CD2 1 
ATOM   1397 C CE1 . TYR A 1 214 ? 2.203   -11.258 -7.960  1.00 13.48 ? 181 TYR A CE1 1 
ATOM   1398 C CE2 . TYR A 1 214 ? 3.359   -13.293 -8.267  1.00 13.66 ? 181 TYR A CE2 1 
ATOM   1399 C CZ  . TYR A 1 214 ? 3.343   -11.914 -8.382  1.00 13.63 ? 181 TYR A CZ  1 
ATOM   1400 O OH  . TYR A 1 214 ? 4.436   -11.185 -8.876  1.00 16.29 ? 181 TYR A OH  1 
ATOM   1401 N N   . MET A 1 215 ? -2.805  -16.284 -7.481  1.00 14.39 ? 182 MET A N   1 
ATOM   1402 C CA  A MET A 1 215 ? -4.117  -16.827 -7.036  0.50 14.47 ? 182 MET A CA  1 
ATOM   1403 C CA  B MET A 1 215 ? -4.108  -16.817 -7.006  0.50 15.34 ? 182 MET A CA  1 
ATOM   1404 C C   . MET A 1 215 ? -3.840  -18.131 -6.287  1.00 14.11 ? 182 MET A C   1 
ATOM   1405 O O   . MET A 1 215 ? -3.384  -19.086 -6.927  1.00 14.56 ? 182 MET A O   1 
ATOM   1406 C CB  A MET A 1 215 ? -5.024  -17.076 -8.245  0.50 16.08 ? 182 MET A CB  1 
ATOM   1407 C CB  B MET A 1 215 ? -5.091  -17.070 -8.145  0.50 18.39 ? 182 MET A CB  1 
ATOM   1408 C CG  A MET A 1 215 ? -6.432  -17.557 -7.894  0.50 17.39 ? 182 MET A CG  1 
ATOM   1409 C CG  B MET A 1 215 ? -6.366  -17.750 -7.659  0.50 21.30 ? 182 MET A CG  1 
ATOM   1410 S SD  A MET A 1 215 ? -7.423  -16.359 -6.987  0.50 17.73 ? 182 MET A SD  1 
ATOM   1411 S SD  B MET A 1 215 ? -7.763  -17.360 -8.701  0.50 24.70 ? 182 MET A SD  1 
ATOM   1412 C CE  A MET A 1 215 ? -9.038  -17.134 -7.104  0.50 19.54 ? 182 MET A CE  1 
ATOM   1413 C CE  B MET A 1 215 ? -9.134  -17.950 -7.704  0.50 23.06 ? 182 MET A CE  1 
ATOM   1414 N N   . ALA A 1 216 ? -4.049  -18.143 -4.991  1.00 11.47 ? 183 ALA A N   1 
ATOM   1415 C CA  . ALA A 1 216 ? -3.850  -19.355 -4.203  1.00 11.92 ? 183 ALA A CA  1 
ATOM   1416 C C   . ALA A 1 216 ? -4.972  -20.347 -4.567  1.00 14.12 ? 183 ALA A C   1 
ATOM   1417 O O   . ALA A 1 216 ? -6.123  -19.925 -4.977  1.00 12.65 ? 183 ALA A O   1 
ATOM   1418 C CB  . ALA A 1 216 ? -3.812  -19.082 -2.710  1.00 12.11 ? 183 ALA A CB  1 
ATOM   1419 N N   . LYS A 1 217 ? -4.652  -21.625 -4.487  1.00 14.11 ? 184 LYS A N   1 
ATOM   1420 C CA  . LYS A 1 217 ? -5.549  -22.708 -4.906  1.00 14.34 ? 184 LYS A CA  1 
ATOM   1421 C C   . LYS A 1 217 ? -6.657  -22.852 -3.882  1.00 14.67 ? 184 LYS A C   1 
ATOM   1422 O O   . LYS A 1 217 ? -7.660  -23.507 -4.242  1.00 16.36 ? 184 LYS A O   1 
ATOM   1423 C CB  . LYS A 1 217 ? -4.741  -23.987 -5.082  1.00 15.82 ? 184 LYS A CB  1 
ATOM   1424 C CG  . LYS A 1 217 ? -3.990  -24.022 -6.413  1.00 16.28 ? 184 LYS A CG  1 
ATOM   1425 C CD  . LYS A 1 217 ? -2.823  -25.021 -6.438  1.00 17.08 ? 184 LYS A CD  1 
ATOM   1426 C CE  . LYS A 1 217 ? -2.012  -24.964 -7.720  1.00 19.49 ? 184 LYS A CE  1 
ATOM   1427 N NZ  . LYS A 1 217 ? -0.865  -25.910 -7.675  1.00 20.65 ? 184 LYS A NZ  1 
ATOM   1428 N N   . LYS A 1 218 ? -6.448  -22.357 -2.667  1.00 13.20 ? 185 LYS A N   1 
ATOM   1429 C CA  . LYS A 1 218 ? -7.485  -22.207 -1.613  1.00 15.52 ? 185 LYS A CA  1 
ATOM   1430 C C   . LYS A 1 218 ? -7.483  -20.759 -1.124  1.00 15.38 ? 185 LYS A C   1 
ATOM   1431 O O   . LYS A 1 218 ? -6.439  -20.059 -1.251  1.00 14.26 ? 185 LYS A O   1 
ATOM   1432 C CB  . LYS A 1 218 ? -7.185  -23.144 -0.448  1.00 18.98 ? 185 LYS A CB  1 
ATOM   1433 C CG  . LYS A 1 218 ? -7.252  -24.623 -0.810  1.00 24.89 ? 185 LYS A CG  1 
ATOM   1434 C CD  . LYS A 1 218 ? -8.649  -25.143 -1.262  1.00 26.38 ? 185 LYS A CD  1 
ATOM   1435 C CE  . LYS A 1 218 ? -8.620  -26.618 -1.634  1.00 33.59 ? 185 LYS A CE  1 
ATOM   1436 N NZ  . LYS A 1 218 ? -8.291  -26.807 -3.057  1.00 32.66 ? 185 LYS A NZ  1 
ATOM   1437 N N   . PRO A 1 219 ? -8.648  -20.234 -0.646  1.00 14.27 ? 186 PRO A N   1 
ATOM   1438 C CA  . PRO A 1 219 ? -8.796  -18.828 -0.238  1.00 14.65 ? 186 PRO A CA  1 
ATOM   1439 C C   . PRO A 1 219 ? -8.173  -18.537 1.125   1.00 13.55 ? 186 PRO A C   1 
ATOM   1440 O O   . PRO A 1 219 ? -8.865  -18.247 2.069   1.00 15.43 ? 186 PRO A O   1 
ATOM   1441 C CB  . PRO A 1 219 ? -10.316 -18.629 -0.173  1.00 14.65 ? 186 PRO A CB  1 
ATOM   1442 C CG  . PRO A 1 219 ? -10.848 -20.008 0.222   1.00 15.60 ? 186 PRO A CG  1 
ATOM   1443 C CD  . PRO A 1 219 ? -9.928  -20.973 -0.491  1.00 16.50 ? 186 PRO A CD  1 
ATOM   1444 N N   . VAL A 1 220 ? -6.861  -18.683 1.197   1.00 13.17 ? 187 VAL A N   1 
ATOM   1445 C CA  . VAL A 1 220 ? -6.088  -18.341 2.407   1.00 13.98 ? 187 VAL A CA  1 
ATOM   1446 C C   . VAL A 1 220 ? -6.031  -16.823 2.483   1.00 12.65 ? 187 VAL A C   1 
ATOM   1447 O O   . VAL A 1 220 ? -6.397  -16.170 1.554   1.00 13.76 ? 187 VAL A O   1 
ATOM   1448 C CB  . VAL A 1 220 ? -4.698  -19.008 2.380   1.00 14.18 ? 187 VAL A CB  1 
ATOM   1449 C CG1 . VAL A 1 220 ? -4.831  -20.538 2.520   1.00 14.68 ? 187 VAL A CG1 1 
ATOM   1450 C CG2 . VAL A 1 220 ? -3.921  -18.614 1.123   1.00 13.89 ? 187 VAL A CG2 1 
ATOM   1451 N N   . GLN A 1 221 ? -5.589  -16.275 3.593   1.00 13.99 ? 188 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 221 ? -5.838  -14.844 3.903   1.00 15.06 ? 188 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 221 ? -5.132  -13.924 2.896   1.00 13.85 ? 188 GLN A C   1 
ATOM   1454 O O   . GLN A 1 221 ? -3.897  -13.974 2.821   1.00 13.27 ? 188 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 221 ? -5.324  -14.514 5.302   1.00 14.44 ? 188 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 221 ? -5.679  -13.118 5.718   1.00 13.58 ? 188 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 221 ? -5.200  -12.880 7.132   1.00 16.22 ? 188 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 221 ? -4.446  -13.674 7.688   1.00 16.42 ? 188 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 221 ? -5.613  -11.761 7.693   1.00 17.31 ? 188 GLN A NE2 1 
ATOM   1460 N N   . LEU A 1 222 ? -5.877  -13.110 2.163   1.00 13.83 ? 189 LEU A N   1 
ATOM   1461 C CA  . LEU A 1 222 ? -5.304  -12.004 1.373   1.00 14.47 ? 189 LEU A CA  1 
ATOM   1462 C C   . LEU A 1 222 ? -4.712  -10.958 2.312   1.00 13.36 ? 189 LEU A C   1 
ATOM   1463 O O   . LEU A 1 222 ? -5.271  -10.646 3.364   1.00 15.20 ? 189 LEU A O   1 
ATOM   1464 C CB  . LEU A 1 222 ? -6.351  -11.410 0.427   1.00 13.17 ? 189 LEU A CB  1 
ATOM   1465 C CG  . LEU A 1 222 ? -6.638  -12.312 -0.789  1.00 13.71 ? 189 LEU A CG  1 
ATOM   1466 C CD1 . LEU A 1 222 ? -7.863  -11.846 -1.520  1.00 13.38 ? 189 LEU A CD1 1 
ATOM   1467 C CD2 . LEU A 1 222 ? -5.471  -12.313 -1.765  1.00 14.19 ? 189 LEU A CD2 1 
ATOM   1468 N N   . PRO A 1 223 ? -3.556  -10.367 1.929   1.00 14.17 ? 190 PRO A N   1 
ATOM   1469 C CA  . PRO A 1 223 ? -3.001  -9.233  2.651   1.00 13.81 ? 190 PRO A CA  1 
ATOM   1470 C C   . PRO A 1 223 ? -3.681  -7.928  2.211   1.00 13.41 ? 190 PRO A C   1 
ATOM   1471 O O   . PRO A 1 223 ? -4.450  -7.942  1.263   1.00 14.37 ? 190 PRO A O   1 
ATOM   1472 C CB  . PRO A 1 223 ? -1.535  -9.271  2.191   1.00 13.54 ? 190 PRO A CB  1 
ATOM   1473 C CG  . PRO A 1 223 ? -1.663  -9.652  0.747   1.00 13.82 ? 190 PRO A CG  1 
ATOM   1474 C CD  . PRO A 1 223 ? -2.790  -10.663 0.708   1.00 14.82 ? 190 PRO A CD  1 
ATOM   1475 N N   . GLY A 1 224 ? -3.319  -6.817  2.872   1.00 16.25 ? 191 GLY A N   1 
ATOM   1476 C CA  . GLY A 1 224 ? -3.574  -5.449  2.362   1.00 16.63 ? 191 GLY A CA  1 
ATOM   1477 C C   . GLY A 1 224 ? -2.465  -5.052  1.421   1.00 19.12 ? 191 GLY A C   1 
ATOM   1478 O O   . GLY A 1 224 ? -1.625  -5.913  1.009   1.00 22.42 ? 191 GLY A O   1 
ATOM   1479 N N   . ALA A 1 225 ? -2.424  -3.791  1.061   1.00 15.89 ? 192 ALA A N   1 
ATOM   1480 C CA  . ALA A 1 225 ? -1.438  -3.231  0.140   1.00 16.96 ? 192 ALA A CA  1 
ATOM   1481 C C   . ALA A 1 225 ? -0.079  -3.168  0.832   1.00 16.20 ? 192 ALA A C   1 
ATOM   1482 O O   . ALA A 1 225 ? 0.021   -2.821  2.028   1.00 16.86 ? 192 ALA A O   1 
ATOM   1483 C CB  . ALA A 1 225 ? -1.874  -1.855  -0.328  1.00 19.67 ? 192 ALA A CB  1 
ATOM   1484 N N   . TYR A 1 226 ? 0.934   -3.554  0.103   1.00 14.72 ? 193 TYR A N   1 
ATOM   1485 C CA  . TYR A 1 226 ? 2.333   -3.552  0.583   1.00 14.95 ? 193 TYR A CA  1 
ATOM   1486 C C   . TYR A 1 226 ? 3.270   -3.529  -0.621  1.00 15.50 ? 193 TYR A C   1 
ATOM   1487 O O   . TYR A 1 226 ? 2.791   -3.421  -1.764  1.00 16.64 ? 193 TYR A O   1 
ATOM   1488 C CB  . TYR A 1 226 ? 2.578   -4.666  1.602   1.00 13.78 ? 193 TYR A CB  1 
ATOM   1489 C CG  . TYR A 1 226 ? 2.705   -6.078  1.059   1.00 13.62 ? 193 TYR A CG  1 
ATOM   1490 C CD1 . TYR A 1 226 ? 1.588   -6.811  0.676   1.00 12.72 ? 193 TYR A CD1 1 
ATOM   1491 C CD2 . TYR A 1 226 ? 3.945   -6.680  0.933   1.00 12.79 ? 193 TYR A CD2 1 
ATOM   1492 C CE1 . TYR A 1 226 ? 1.711   -8.124  0.225   1.00 13.19 ? 193 TYR A CE1 1 
ATOM   1493 C CE2 . TYR A 1 226 ? 4.077   -7.990  0.507   1.00 13.20 ? 193 TYR A CE2 1 
ATOM   1494 C CZ  . TYR A 1 226 ? 2.966   -8.715  0.146   1.00 13.20 ? 193 TYR A CZ  1 
ATOM   1495 O OH  . TYR A 1 226 ? 3.182   -10.010 -0.293  1.00 12.74 ? 193 TYR A OH  1 
ATOM   1496 N N   . LYS A 1 227 ? 4.572   -3.537  -0.348  1.00 16.81 ? 194 LYS A N   1 
ATOM   1497 C CA  . LYS A 1 227 ? 5.638   -3.526  -1.385  1.00 15.69 ? 194 LYS A CA  1 
ATOM   1498 C C   . LYS A 1 227 ? 6.539   -4.749  -1.206  1.00 14.76 ? 194 LYS A C   1 
ATOM   1499 O O   . LYS A 1 227 ? 6.843   -5.107  -0.078  1.00 14.49 ? 194 LYS A O   1 
ATOM   1500 C CB  . LYS A 1 227 ? 6.503   -2.276  -1.264  1.00 18.85 ? 194 LYS A CB  1 
ATOM   1501 C CG  . LYS A 1 227 ? 5.817   -0.977  -1.689  1.00 22.72 ? 194 LYS A CG  1 
ATOM   1502 C CD  . LYS A 1 227 ? 5.301   -0.996  -3.109  1.00 25.72 ? 194 LYS A CD  1 
ATOM   1503 C CE  . LYS A 1 227 ? 5.889   -0.016  -4.107  1.00 27.94 ? 194 LYS A CE  1 
ATOM   1504 N NZ  . LYS A 1 227 ? 7.337   -0.096  -4.271  1.00 30.25 ? 194 LYS A NZ  1 
ATOM   1505 N N   . THR A 1 228 ? 7.017   -5.333  -2.293  1.00 14.29 ? 195 THR A N   1 
ATOM   1506 C CA  . THR A 1 228 ? 8.087   -6.360  -2.232  1.00 15.18 ? 195 THR A CA  1 
ATOM   1507 C C   . THR A 1 228 ? 9.270   -5.795  -2.984  1.00 17.96 ? 195 THR A C   1 
ATOM   1508 O O   . THR A 1 228 ? 9.089   -5.579  -4.199  1.00 15.69 ? 195 THR A O   1 
ATOM   1509 C CB  . THR A 1 228 ? 7.693   -7.705  -2.849  1.00 16.01 ? 195 THR A CB  1 
ATOM   1510 O OG1 . THR A 1 228 ? 6.471   -8.117  -2.233  1.00 17.02 ? 195 THR A OG1 1 
ATOM   1511 C CG2 . THR A 1 228 ? 8.755   -8.780  -2.710  1.00 15.22 ? 195 THR A CG2 1 
ATOM   1512 N N   . ASP A 1 229 ? 10.391  -5.581  -2.298  1.00 16.28 ? 196 ASP A N   1 
ATOM   1513 C CA  . ASP A 1 229 ? 11.678  -5.187  -2.920  1.00 15.30 ? 196 ASP A CA  1 
ATOM   1514 C C   . ASP A 1 229 ? 12.377  -6.459  -3.381  1.00 15.24 ? 196 ASP A C   1 
ATOM   1515 O O   . ASP A 1 229 ? 12.528  -7.395  -2.570  1.00 15.43 ? 196 ASP A O   1 
ATOM   1516 C CB  . ASP A 1 229 ? 12.602  -4.457  -1.954  1.00 17.29 ? 196 ASP A CB  1 
ATOM   1517 C CG  . ASP A 1 229 ? 12.021  -3.125  -1.536  1.00 18.19 ? 196 ASP A CG  1 
ATOM   1518 O OD1 . ASP A 1 229 ? 11.419  -2.461  -2.406  1.00 20.55 ? 196 ASP A OD1 1 
ATOM   1519 O OD2 . ASP A 1 229 ? 12.067  -2.853  -0.294  1.00 20.03 ? 196 ASP A OD2 1 
ATOM   1520 N N   . ILE A 1 230 ? 12.722  -6.491  -4.658  1.00 14.11 ? 197 ILE A N   1 
ATOM   1521 C CA  . ILE A 1 230 ? 13.338  -7.670  -5.300  1.00 13.74 ? 197 ILE A CA  1 
ATOM   1522 C C   . ILE A 1 230 ? 14.648  -7.291  -5.995  1.00 14.79 ? 197 ILE A C   1 
ATOM   1523 O O   . ILE A 1 230 ? 14.644  -6.292  -6.788  1.00 13.84 ? 197 ILE A O   1 
ATOM   1524 C CB  . ILE A 1 230 ? 12.348  -8.245  -6.309  1.00 14.35 ? 197 ILE A CB  1 
ATOM   1525 C CG1 . ILE A 1 230 ? 10.965  -8.474  -5.690  1.00 15.29 ? 197 ILE A CG1 1 
ATOM   1526 C CG2 . ILE A 1 230 ? 12.963  -9.511  -6.847  1.00 13.95 ? 197 ILE A CG2 1 
ATOM   1527 C CD1 . ILE A 1 230 ? 9.868   -8.665  -6.698  1.00 18.76 ? 197 ILE A CD1 1 
ATOM   1528 N N   . LYS A 1 231 ? 15.675  -8.125  -5.847  1.00 14.23 ? 198 LYS A N   1 
ATOM   1529 C CA  . LYS A 1 231 ? 16.871  -8.001  -6.706  1.00 15.81 ? 198 LYS A CA  1 
ATOM   1530 C C   . LYS A 1 231 ? 17.330  -9.353  -7.210  1.00 15.20 ? 198 LYS A C   1 
ATOM   1531 O O   . LYS A 1 231 ? 17.574  -10.258 -6.378  1.00 17.13 ? 198 LYS A O   1 
ATOM   1532 C CB  . LYS A 1 231 ? 17.971  -7.242  -5.958  1.00 19.05 ? 198 LYS A CB  1 
ATOM   1533 C CG  . LYS A 1 231 ? 19.129  -6.870  -6.882  1.00 22.25 ? 198 LYS A CG  1 
ATOM   1534 C CD  . LYS A 1 231 ? 20.166  -5.968  -6.238  1.00 25.14 ? 198 LYS A CD  1 
ATOM   1535 C CE  . LYS A 1 231 ? 21.016  -5.290  -7.293  1.00 29.17 ? 198 LYS A CE  1 
ATOM   1536 N NZ  . LYS A 1 231 ? 21.667  -6.310  -8.142  1.00 33.22 ? 198 LYS A NZ  1 
ATOM   1537 N N   . LEU A 1 232 ? 17.421  -9.503  -8.538  1.00 14.20 ? 199 LEU A N   1 
ATOM   1538 C CA  . LEU A 1 232 ? 17.761  -10.776 -9.162  1.00 15.25 ? 199 LEU A CA  1 
ATOM   1539 C C   . LEU A 1 232 ? 19.116  -10.603 -9.851  1.00 15.28 ? 199 LEU A C   1 
ATOM   1540 O O   . LEU A 1 232 ? 19.263  -9.634  -10.653 1.00 15.81 ? 199 LEU A O   1 
ATOM   1541 C CB  . LEU A 1 232 ? 16.627  -11.183 -10.095 1.00 17.43 ? 199 LEU A CB  1 
ATOM   1542 C CG  . LEU A 1 232 ? 16.765  -12.531 -10.794 1.00 21.75 ? 199 LEU A CG  1 
ATOM   1543 C CD1 . LEU A 1 232 ? 15.483  -12.776 -11.565 1.00 25.89 ? 199 LEU A CD1 1 
ATOM   1544 C CD2 . LEU A 1 232 ? 17.953  -12.552 -11.761 1.00 26.34 ? 199 LEU A CD2 1 
ATOM   1545 N N   . ASP A 1 233 ? 20.024  -11.530 -9.571  1.00 15.87 ? 200 ASP A N   1 
ATOM   1546 C CA  . ASP A 1 233 ? 21.382  -11.546 -10.177 1.00 16.89 ? 200 ASP A CA  1 
ATOM   1547 C C   . ASP A 1 233 ? 21.599  -12.809 -10.977 1.00 15.46 ? 200 ASP A C   1 
ATOM   1548 O O   . ASP A 1 233 ? 21.400  -13.925 -10.469 1.00 15.40 ? 200 ASP A O   1 
ATOM   1549 C CB  . ASP A 1 233 ? 22.515  -11.346 -9.152  1.00 17.82 ? 200 ASP A CB  1 
ATOM   1550 C CG  . ASP A 1 233 ? 22.317  -10.136 -8.271  1.00 17.95 ? 200 ASP A CG  1 
ATOM   1551 O OD1 . ASP A 1 233 ? 21.935  -9.104  -8.804  1.00 20.18 ? 200 ASP A OD1 1 
ATOM   1552 O OD2 . ASP A 1 233 ? 22.469  -10.247 -7.060  1.00 19.96 ? 200 ASP A OD2 1 
ATOM   1553 N N   . ILE A 1 234 ? 22.102  -12.639 -12.204 1.00 16.29 ? 201 ILE A N   1 
ATOM   1554 C CA  . ILE A 1 234 ? 22.756  -13.766 -12.913 1.00 16.07 ? 201 ILE A CA  1 
ATOM   1555 C C   . ILE A 1 234 ? 24.141  -13.927 -12.336 1.00 16.16 ? 201 ILE A C   1 
ATOM   1556 O O   . ILE A 1 234 ? 24.962  -12.994 -12.531 1.00 17.43 ? 201 ILE A O   1 
ATOM   1557 C CB  . ILE A 1 234 ? 22.784  -13.572 -14.429 1.00 16.53 ? 201 ILE A CB  1 
ATOM   1558 C CG1 . ILE A 1 234 ? 21.379  -13.179 -14.875 1.00 16.33 ? 201 ILE A CG1 1 
ATOM   1559 C CG2 . ILE A 1 234 ? 23.300  -14.815 -15.058 1.00 16.97 ? 201 ILE A CG2 1 
ATOM   1560 C CD1 . ILE A 1 234 ? 20.347  -14.242 -14.588 1.00 17.09 ? 201 ILE A CD1 1 
ATOM   1561 N N   . THR A 1 235 ? 24.400  -15.057 -11.663 1.00 14.38 ? 202 THR A N   1 
ATOM   1562 C CA  . THR A 1 235 ? 25.686  -15.213 -10.967 1.00 16.51 ? 202 THR A CA  1 
ATOM   1563 C C   . THR A 1 235 ? 26.683  -16.063 -11.732 1.00 18.73 ? 202 THR A C   1 
ATOM   1564 O O   . THR A 1 235 ? 27.856  -15.979 -11.382 1.00 20.02 ? 202 THR A O   1 
ATOM   1565 C CB  . THR A 1 235 ? 25.419  -15.807 -9.586  1.00 16.54 ? 202 THR A CB  1 
ATOM   1566 O OG1 . THR A 1 235 ? 24.906  -17.100 -9.852  1.00 17.83 ? 202 THR A OG1 1 
ATOM   1567 C CG2 . THR A 1 235 ? 24.418  -15.008 -8.802  1.00 16.61 ? 202 THR A CG2 1 
ATOM   1568 N N   . SER A 1 236 ? 26.254  -16.897 -12.669 1.00 17.73 ? 203 SER A N   1 
ATOM   1569 C CA  . SER A 1 236 ? 27.135  -17.711 -13.533 1.00 21.37 ? 203 SER A CA  1 
ATOM   1570 C C   . SER A 1 236 ? 26.412  -17.965 -14.853 1.00 21.13 ? 203 SER A C   1 
ATOM   1571 O O   . SER A 1 236 ? 25.198  -18.155 -14.831 1.00 22.79 ? 203 SER A O   1 
ATOM   1572 C CB  . SER A 1 236 ? 27.492  -19.026 -12.891 1.00 20.63 ? 203 SER A CB  1 
ATOM   1573 O OG  . SER A 1 236 ? 28.485  -19.661 -13.637 1.00 23.67 ? 203 SER A OG  1 
ATOM   1574 N N   . HIS A 1 237 ? 27.156  -18.150 -15.929 1.00 20.70 ? 204 HIS A N   1 
ATOM   1575 C CA  . HIS A 1 237 ? 26.605  -18.698 -17.186 1.00 20.74 ? 204 HIS A CA  1 
ATOM   1576 C C   . HIS A 1 237 ? 27.715  -19.210 -18.107 1.00 20.37 ? 204 HIS A C   1 
ATOM   1577 O O   . HIS A 1 237 ? 28.826  -18.634 -18.062 1.00 23.60 ? 204 HIS A O   1 
ATOM   1578 C CB  . HIS A 1 237 ? 25.782  -17.621 -17.877 1.00 21.36 ? 204 HIS A CB  1 
ATOM   1579 C CG  . HIS A 1 237 ? 26.547  -16.461 -18.353 1.00 22.05 ? 204 HIS A CG  1 
ATOM   1580 N ND1 . HIS A 1 237 ? 26.773  -15.336 -17.560 1.00 22.78 ? 204 HIS A ND1 1 
ATOM   1581 C CD2 . HIS A 1 237 ? 27.120  -16.216 -19.557 1.00 20.52 ? 204 HIS A CD2 1 
ATOM   1582 C CE1 . HIS A 1 237 ? 27.487  -14.469 -18.245 1.00 21.71 ? 204 HIS A CE1 1 
ATOM   1583 N NE2 . HIS A 1 237 ? 27.682  -14.984 -19.479 1.00 20.27 ? 204 HIS A NE2 1 
ATOM   1584 N N   . ASN A 1 238 ? 27.399  -20.200 -18.925 1.00 21.00 ? 205 ASN A N   1 
ATOM   1585 C CA  . ASN A 1 238 ? 28.281  -20.574 -20.068 1.00 20.44 ? 205 ASN A CA  1 
ATOM   1586 C C   . ASN A 1 238 ? 28.103  -19.554 -21.205 1.00 22.80 ? 205 ASN A C   1 
ATOM   1587 O O   . ASN A 1 238 ? 27.325  -18.608 -21.099 1.00 25.88 ? 205 ASN A O   1 
ATOM   1588 C CB  . ASN A 1 238 ? 28.140  -22.041 -20.463 1.00 20.28 ? 205 ASN A CB  1 
ATOM   1589 C CG  . ASN A 1 238 ? 26.813  -22.370 -21.076 1.00 19.93 ? 205 ASN A CG  1 
ATOM   1590 O OD1 . ASN A 1 238 ? 25.960  -21.497 -21.188 1.00 22.04 ? 205 ASN A OD1 1 
ATOM   1591 N ND2 . ASN A 1 238 ? 26.664  -23.605 -21.517 1.00 18.01 ? 205 ASN A ND2 1 
ATOM   1592 N N   . GLU A 1 239 ? 28.898  -19.712 -22.255 1.00 26.08 ? 206 GLU A N   1 
ATOM   1593 C CA  . GLU A 1 239 ? 28.981  -18.734 -23.358 1.00 25.23 ? 206 GLU A CA  1 
ATOM   1594 C C   . GLU A 1 239 ? 27.585  -18.471 -23.977 1.00 23.52 ? 206 GLU A C   1 
ATOM   1595 O O   . GLU A 1 239 ? 27.200  -17.300 -24.242 1.00 22.97 ? 206 GLU A O   1 
ATOM   1596 C CB  . GLU A 1 239 ? 29.953  -19.294 -24.390 1.00 26.86 ? 206 GLU A CB  1 
ATOM   1597 C CG  . GLU A 1 239 ? 29.922  -18.425 -25.618 1.00 32.23 ? 206 GLU A CG  1 
ATOM   1598 C CD  . GLU A 1 239 ? 31.016  -18.697 -26.620 1.00 29.64 ? 206 GLU A CD  1 
ATOM   1599 O OE1 . GLU A 1 239 ? 31.887  -19.530 -26.335 1.00 25.68 ? 206 GLU A OE1 1 
ATOM   1600 O OE2 . GLU A 1 239 ? 31.008  -17.999 -27.625 1.00 33.79 ? 206 GLU A OE2 1 
ATOM   1601 N N   . ASP A 1 240 ? 26.833  -19.520 -24.228 1.00 21.85 ? 207 ASP A N   1 
ATOM   1602 C CA  . ASP A 1 240 ? 25.601  -19.405 -25.053 1.00 21.57 ? 207 ASP A CA  1 
ATOM   1603 C C   . ASP A 1 240 ? 24.382  -19.415 -24.121 1.00 21.63 ? 207 ASP A C   1 
ATOM   1604 O O   . ASP A 1 240 ? 23.267  -19.481 -24.619 1.00 23.31 ? 207 ASP A O   1 
ATOM   1605 C CB  . ASP A 1 240 ? 25.573  -20.478 -26.135 1.00 21.68 ? 207 ASP A CB  1 
ATOM   1606 C CG  . ASP A 1 240 ? 25.477  -21.898 -25.628 1.00 25.21 ? 207 ASP A CG  1 
ATOM   1607 O OD1 . ASP A 1 240 ? 25.429  -22.112 -24.349 1.00 22.96 ? 207 ASP A OD1 1 
ATOM   1608 O OD2 . ASP A 1 240 ? 25.356  -22.790 -26.495 1.00 24.56 ? 207 ASP A OD2 1 
ATOM   1609 N N   . TYR A 1 241 ? 24.582  -19.313 -22.804 1.00 23.05 ? 208 TYR A N   1 
ATOM   1610 C CA  . TYR A 1 241 ? 23.472  -19.310 -21.804 1.00 20.02 ? 208 TYR A CA  1 
ATOM   1611 C C   . TYR A 1 241 ? 22.588  -20.544 -21.929 1.00 19.70 ? 208 TYR A C   1 
ATOM   1612 O O   . TYR A 1 241 ? 21.353  -20.442 -21.727 1.00 19.19 ? 208 TYR A O   1 
ATOM   1613 C CB  . TYR A 1 241 ? 22.596  -18.064 -21.911 1.00 22.28 ? 208 TYR A CB  1 
ATOM   1614 C CG  . TYR A 1 241 ? 23.264  -16.783 -21.463 1.00 18.35 ? 208 TYR A CG  1 
ATOM   1615 C CD1 . TYR A 1 241 ? 24.209  -16.134 -22.244 1.00 21.78 ? 208 TYR A CD1 1 
ATOM   1616 C CD2 . TYR A 1 241 ? 22.942  -16.208 -20.235 1.00 19.70 ? 208 TYR A CD2 1 
ATOM   1617 C CE1 . TYR A 1 241 ? 24.812  -14.956 -21.806 1.00 21.92 ? 208 TYR A CE1 1 
ATOM   1618 C CE2 . TYR A 1 241 ? 23.484  -15.005 -19.798 1.00 19.57 ? 208 TYR A CE2 1 
ATOM   1619 C CZ  . TYR A 1 241 ? 24.452  -14.390 -20.587 1.00 23.30 ? 208 TYR A CZ  1 
ATOM   1620 O OH  . TYR A 1 241 ? 25.028  -13.214 -20.165 1.00 23.06 ? 208 TYR A OH  1 
ATOM   1621 N N   . THR A 1 242 ? 23.172  -21.703 -22.195 1.00 17.68 ? 209 THR A N   1 
ATOM   1622 C CA  . THR A 1 242 ? 22.469  -22.996 -22.137 1.00 18.34 ? 209 THR A CA  1 
ATOM   1623 C C   . THR A 1 242 ? 22.592  -23.543 -20.721 1.00 18.48 ? 209 THR A C   1 
ATOM   1624 O O   . THR A 1 242 ? 21.791  -24.368 -20.355 1.00 20.17 ? 209 THR A O   1 
ATOM   1625 C CB  . THR A 1 242 ? 22.966  -23.997 -23.178 1.00 22.21 ? 209 THR A CB  1 
ATOM   1626 O OG1 . THR A 1 242 ? 24.381  -24.093 -23.129 1.00 19.99 ? 209 THR A OG1 1 
ATOM   1627 C CG2 . THR A 1 242 ? 22.519  -23.600 -24.565 1.00 21.05 ? 209 THR A CG2 1 
ATOM   1628 N N   . ILE A 1 243 ? 23.553  -23.030 -19.947 1.00 19.17 ? 210 ILE A N   1 
ATOM   1629 C CA  . ILE A 1 243 ? 23.719  -23.337 -18.508 1.00 18.08 ? 210 ILE A CA  1 
ATOM   1630 C C   . ILE A 1 243 ? 23.852  -22.023 -17.742 1.00 16.52 ? 210 ILE A C   1 
ATOM   1631 O O   . ILE A 1 243 ? 24.681  -21.191 -18.107 1.00 19.71 ? 210 ILE A O   1 
ATOM   1632 C CB  . ILE A 1 243 ? 24.931  -24.237 -18.345 1.00 19.20 ? 210 ILE A CB  1 
ATOM   1633 C CG1 . ILE A 1 243 ? 24.650  -25.626 -18.916 1.00 20.99 ? 210 ILE A CG1 1 
ATOM   1634 C CG2 . ILE A 1 243 ? 25.288  -24.308 -16.879 1.00 21.57 ? 210 ILE A CG2 1 
ATOM   1635 C CD1 . ILE A 1 243 ? 25.898  -26.492 -19.020 1.00 23.46 ? 210 ILE A CD1 1 
ATOM   1636 N N   . VAL A 1 244 ? 23.015  -21.775 -16.738 1.00 17.38 ? 211 VAL A N   1 
ATOM   1637 C CA  . VAL A 1 244 ? 22.903  -20.431 -16.091 1.00 14.22 ? 211 VAL A CA  1 
ATOM   1638 C C   . VAL A 1 244 ? 22.617  -20.649 -14.596 1.00 14.45 ? 211 VAL A C   1 
ATOM   1639 O O   . VAL A 1 244 ? 21.915  -21.618 -14.275 1.00 15.38 ? 211 VAL A O   1 
ATOM   1640 C CB  . VAL A 1 244 ? 21.775  -19.583 -16.720 1.00 15.89 ? 211 VAL A CB  1 
ATOM   1641 C CG1 . VAL A 1 244 ? 21.695  -18.186 -16.116 1.00 16.02 ? 211 VAL A CG1 1 
ATOM   1642 C CG2 . VAL A 1 244 ? 21.915  -19.512 -18.238 1.00 16.16 ? 211 VAL A CG2 1 
ATOM   1643 N N   . GLU A 1 245 ? 23.171  -19.805 -13.736 1.00 14.12 ? 212 GLU A N   1 
ATOM   1644 C CA  . GLU A 1 245 ? 22.796  -19.758 -12.296 1.00 13.64 ? 212 GLU A CA  1 
ATOM   1645 C C   . GLU A 1 245 ? 22.224  -18.381 -11.963 1.00 15.11 ? 212 GLU A C   1 
ATOM   1646 O O   . GLU A 1 245 ? 22.736  -17.380 -12.472 1.00 14.91 ? 212 GLU A O   1 
ATOM   1647 C CB  . GLU A 1 245 ? 24.007  -20.141 -11.436 1.00 14.06 ? 212 GLU A CB  1 
ATOM   1648 C CG  . GLU A 1 245 ? 24.566  -21.502 -11.823 1.00 14.80 ? 212 GLU A CG  1 
ATOM   1649 C CD  . GLU A 1 245 ? 25.684  -21.955 -10.904 1.00 16.68 ? 212 GLU A CD  1 
ATOM   1650 O OE1 . GLU A 1 245 ? 25.772  -21.420 -9.740  1.00 19.77 ? 212 GLU A OE1 1 
ATOM   1651 O OE2 . GLU A 1 245 ? 26.502  -22.841 -11.350 1.00 19.14 ? 212 GLU A OE2 1 
ATOM   1652 N N   . GLN A 1 246 ? 21.241  -18.332 -11.063 1.00 14.48 ? 213 GLN A N   1 
ATOM   1653 C CA  . GLN A 1 246 ? 20.629  -17.058 -10.593 1.00 16.49 ? 213 GLN A CA  1 
ATOM   1654 C C   . GLN A 1 246 ? 20.506  -17.058 -9.076  1.00 16.02 ? 213 GLN A C   1 
ATOM   1655 O O   . GLN A 1 246 ? 20.236  -18.137 -8.535  1.00 17.08 ? 213 GLN A O   1 
ATOM   1656 C CB  . GLN A 1 246 ? 19.150  -16.845 -11.004 1.00 19.86 ? 213 GLN A CB  1 
ATOM   1657 C CG  . GLN A 1 246 ? 18.756  -17.518 -12.256 1.00 21.76 ? 213 GLN A CG  1 
ATOM   1658 C CD  . GLN A 1 246 ? 17.557  -16.963 -12.981 1.00 16.86 ? 213 GLN A CD  1 
ATOM   1659 O OE1 . GLN A 1 246 ? 17.577  -16.933 -14.207 1.00 18.06 ? 213 GLN A OE1 1 
ATOM   1660 N NE2 . GLN A 1 246 ? 16.480  -16.662 -12.267 1.00 15.21 ? 213 GLN A NE2 1 
ATOM   1661 N N   . TYR A 1 247 ? 20.488  -15.857 -8.519  1.00 14.06 ? 214 TYR A N   1 
ATOM   1662 C CA  . TYR A 1 247 ? 20.212  -15.551 -7.099  1.00 13.80 ? 214 TYR A CA  1 
ATOM   1663 C C   . TYR A 1 247 ? 19.132  -14.477 -7.046  1.00 15.66 ? 214 TYR A C   1 
ATOM   1664 O O   . TYR A 1 247 ? 19.205  -13.539 -7.825  1.00 14.55 ? 214 TYR A O   1 
ATOM   1665 C CB  . TYR A 1 247 ? 21.502  -15.038 -6.429  1.00 13.95 ? 214 TYR A CB  1 
ATOM   1666 C CG  . TYR A 1 247 ? 21.271  -14.452 -5.063  1.00 15.02 ? 214 TYR A CG  1 
ATOM   1667 C CD1 . TYR A 1 247 ? 21.012  -15.258 -3.969  1.00 16.20 ? 214 TYR A CD1 1 
ATOM   1668 C CD2 . TYR A 1 247 ? 21.225  -13.093 -4.849  1.00 17.09 ? 214 TYR A CD2 1 
ATOM   1669 C CE1 . TYR A 1 247 ? 20.815  -14.733 -2.698  1.00 17.96 ? 214 TYR A CE1 1 
ATOM   1670 C CE2 . TYR A 1 247 ? 21.056  -12.551 -3.573  1.00 17.06 ? 214 TYR A CE2 1 
ATOM   1671 C CZ  . TYR A 1 247 ? 20.845  -13.366 -2.487  1.00 18.12 ? 214 TYR A CZ  1 
ATOM   1672 O OH  . TYR A 1 247 ? 20.556  -12.767 -1.279  1.00 21.45 ? 214 TYR A OH  1 
ATOM   1673 N N   . GLU A 1 248 ? 18.196  -14.601 -6.119  1.00 13.29 ? 215 GLU A N   1 
ATOM   1674 C CA  . GLU A 1 248 ? 17.224  -13.535 -5.877  1.00 13.51 ? 215 GLU A CA  1 
ATOM   1675 C C   . GLU A 1 248 ? 17.022  -13.338 -4.392  1.00 13.74 ? 215 GLU A C   1 
ATOM   1676 O O   . GLU A 1 248 ? 16.965  -14.344 -3.653  1.00 13.13 ? 215 GLU A O   1 
ATOM   1677 C CB  . GLU A 1 248 ? 15.905  -13.877 -6.565  1.00 13.73 ? 215 GLU A CB  1 
ATOM   1678 C CG  . GLU A 1 248 ? 14.893  -12.727 -6.548  1.00 16.24 ? 215 GLU A CG  1 
ATOM   1679 C CD  . GLU A 1 248 ? 13.656  -13.064 -7.364  1.00 15.45 ? 215 GLU A CD  1 
ATOM   1680 O OE1 . GLU A 1 248 ? 13.811  -13.173 -8.617  1.00 14.74 ? 215 GLU A OE1 1 
ATOM   1681 O OE2 . GLU A 1 248 ? 12.538  -13.190 -6.757  1.00 16.91 ? 215 GLU A OE2 1 
ATOM   1682 N N   . ARG A 1 249 ? 16.891  -12.088 -3.981  1.00 13.10 ? 216 ARG A N   1 
ATOM   1683 C CA  . ARG A 1 249 ? 16.522  -11.692 -2.601  1.00 14.84 ? 216 ARG A CA  1 
ATOM   1684 C C   . ARG A 1 249 ? 15.240  -10.869 -2.728  1.00 14.03 ? 216 ARG A C   1 
ATOM   1685 O O   . ARG A 1 249 ? 15.140  -9.989  -3.601  1.00 16.46 ? 216 ARG A O   1 
ATOM   1686 C CB  . ARG A 1 249 ? 17.656  -10.858 -1.973  1.00 18.17 ? 216 ARG A CB  1 
ATOM   1687 C CG  . ARG A 1 249 ? 17.347  -10.234 -0.611  1.00 24.22 ? 216 ARG A CG  1 
ATOM   1688 C CD  . ARG A 1 249 ? 18.553  -9.822  0.206   1.00 28.77 ? 216 ARG A CD  1 
ATOM   1689 N NE  . ARG A 1 249 ? 18.190  -9.755  1.603   1.00 32.04 ? 216 ARG A NE  1 
ATOM   1690 N N   . ALA A 1 250 ? 14.253  -11.168 -1.895  1.00 13.76 ? 217 ALA A N   1 
ATOM   1691 C CA  . ALA A 1 250 ? 12.953  -10.507 -1.945  1.00 13.35 ? 217 ALA A CA  1 
ATOM   1692 C C   . ALA A 1 250 ? 12.451  -10.322 -0.529  1.00 13.93 ? 217 ALA A C   1 
ATOM   1693 O O   . ALA A 1 250 ? 12.502  -11.268 0.273   1.00 14.30 ? 217 ALA A O   1 
ATOM   1694 C CB  . ALA A 1 250 ? 11.994  -11.221 -2.813  1.00 14.22 ? 217 ALA A CB  1 
ATOM   1695 N N   . GLU A 1 251 ? 11.960  -9.133  -0.243  1.00 14.20 ? 218 GLU A N   1 
ATOM   1696 C CA  . GLU A 1 251 ? 11.464  -8.808  1.099   1.00 16.50 ? 218 GLU A CA  1 
ATOM   1697 C C   . GLU A 1 251 ? 10.226  -7.934  1.040   1.00 15.44 ? 218 GLU A C   1 
ATOM   1698 O O   . GLU A 1 251 ? 10.221  -6.897  0.318   1.00 16.30 ? 218 GLU A O   1 
ATOM   1699 C CB  . GLU A 1 251 ? 12.566  -8.131  1.906   1.00 17.59 ? 218 GLU A CB  1 
ATOM   1700 C CG  . GLU A 1 251 ? 12.142  -7.976  3.355   1.00 22.93 ? 218 GLU A CG  1 
ATOM   1701 C CD  . GLU A 1 251 ? 13.223  -7.551  4.339   1.00 26.39 ? 218 GLU A CD  1 
ATOM   1702 O OE1 . GLU A 1 251 ? 12.852  -7.226  5.477   1.00 28.30 ? 218 GLU A OE1 1 
ATOM   1703 O OE2 . GLU A 1 251 ? 14.431  -7.563  3.973   1.00 31.10 ? 218 GLU A OE2 1 
ATOM   1704 N N   . GLY A 1 252 ? 9.174   -8.332  1.726   1.00 13.99 ? 219 GLY A N   1 
ATOM   1705 C CA  . GLY A 1 252 ? 7.938   -7.536  1.773   1.00 14.61 ? 219 GLY A CA  1 
ATOM   1706 C C   . GLY A 1 252 ? 7.929   -6.592  2.956   1.00 15.88 ? 219 GLY A C   1 
ATOM   1707 O O   . GLY A 1 252 ? 8.526   -6.937  4.008   1.00 15.58 ? 219 GLY A O   1 
ATOM   1708 N N   . ARG A 1 253 ? 7.325   -5.409  2.778   1.00 16.37 ? 220 ARG A N   1 
ATOM   1709 C CA  . ARG A 1 253 ? 7.288   -4.329  3.808   1.00 15.96 ? 220 ARG A CA  1 
ATOM   1710 C C   . ARG A 1 253 ? 6.069   -3.448  3.532   1.00 16.63 ? 220 ARG A C   1 
ATOM   1711 O O   . ARG A 1 253 ? 5.535   -3.458  2.399   1.00 15.66 ? 220 ARG A O   1 
ATOM   1712 C CB  . ARG A 1 253 ? 8.562   -3.493  3.778   1.00 16.63 ? 220 ARG A CB  1 
ATOM   1713 C CG  . ARG A 1 253 ? 8.863   -2.923  2.394   1.00 17.63 ? 220 ARG A CG  1 
ATOM   1714 C CD  . ARG A 1 253 ? 9.921   -1.848  2.412   1.00 18.73 ? 220 ARG A CD  1 
ATOM   1715 N NE  . ARG A 1 253 ? 10.169  -1.368  1.060   1.00 19.68 ? 220 ARG A NE  1 
ATOM   1716 C CZ  . ARG A 1 253 ? 9.441   -0.440  0.435   1.00 19.49 ? 220 ARG A CZ  1 
ATOM   1717 N NH1 . ARG A 1 253 ? 8.404   0.114   1.028   1.00 19.56 ? 220 ARG A NH1 1 
ATOM   1718 N NH2 . ARG A 1 253 ? 9.724   -0.106  -0.801  1.00 20.75 ? 220 ARG A NH2 1 
ATOM   1719 N N   . HIS A 1 254 ? 5.640   -2.701  4.522   1.00 16.41 ? 221 HIS A N   1 
ATOM   1720 C CA  . HIS A 1 254 ? 4.518   -1.745  4.335   1.00 18.92 ? 221 HIS A CA  1 
ATOM   1721 C C   . HIS A 1 254 ? 4.954   -0.680  3.320   1.00 19.80 ? 221 HIS A C   1 
ATOM   1722 O O   . HIS A 1 254 ? 6.197   -0.452  3.178   1.00 20.28 ? 221 HIS A O   1 
ATOM   1723 C CB  . HIS A 1 254 ? 4.148   -1.125  5.669   1.00 21.75 ? 221 HIS A CB  1 
ATOM   1724 C CG  . HIS A 1 254 ? 3.524   -2.111  6.585   1.00 21.49 ? 221 HIS A CG  1 
ATOM   1725 N ND1 . HIS A 1 254 ? 2.344   -2.774  6.267   1.00 20.91 ? 221 HIS A ND1 1 
ATOM   1726 C CD2 . HIS A 1 254 ? 3.926   -2.558  7.797   1.00 23.33 ? 221 HIS A CD2 1 
ATOM   1727 C CE1 . HIS A 1 254 ? 2.065   -3.585  7.277   1.00 21.09 ? 221 HIS A CE1 1 
ATOM   1728 N NE2 . HIS A 1 254 ? 3.023   -3.461  8.221   1.00 19.69 ? 221 HIS A NE2 1 
ATOM   1729 N N   . SER A 1 255 ? 4.018   -0.047  2.632   1.00 21.44 ? 222 SER A N   1 
ATOM   1730 C CA  . SER A 1 255 ? 4.355   0.960   1.578   1.00 26.81 ? 222 SER A CA  1 
ATOM   1731 C C   . SER A 1 255 ? 4.509   2.387   2.178   1.00 29.00 ? 222 SER A C   1 
ATOM   1732 O O   . SER A 1 255 ? 3.770   3.344   1.771   1.00 26.40 ? 222 SER A O   1 
ATOM   1733 C CB  . SER A 1 255 ? 3.439   0.896   0.379   1.00 29.24 ? 222 SER A CB  1 
ATOM   1734 O OG  . SER A 1 255 ? 2.209   0.267   0.677   1.00 42.44 ? 222 SER A OG  1 
ATOM   1735 N N   . THR A 1 256 ? 5.597   2.557   2.954   1.00 33.70 ? 223 THR A N   1 
ATOM   1736 C CA  . THR A 1 256 ? 6.006   3.772   3.721   1.00 32.93 ? 223 THR A CA  1 
ATOM   1737 C C   . THR A 1 256 ? 7.472   4.187   3.424   1.00 34.77 ? 223 THR A C   1 
ATOM   1738 O O   . THR A 1 256 ? 8.002   4.969   4.200   1.00 37.31 ? 223 THR A O   1 
ATOM   1739 C CB  . THR A 1 256 ? 5.732   3.538   5.224   1.00 33.22 ? 223 THR A CB  1 
ATOM   1740 O OG1 . THR A 1 256 ? 6.477   2.406   5.672   1.00 34.25 ? 223 THR A OG1 1 
ATOM   1741 C CG2 . THR A 1 256 ? 4.270   3.272   5.543   1.00 31.16 ? 223 THR A CG2 1 
ATOM   1742 N N   . GLY A 1 257 ? 8.130   3.711   2.353   1.00 37.56 ? 224 GLY A N   1 
ATOM   1743 C CA  . GLY A 1 257 ? 9.533   4.076   2.000   1.00 35.77 ? 224 GLY A CA  1 
ATOM   1744 C C   . GLY A 1 257 ? 10.512  2.896   2.012   1.00 35.31 ? 224 GLY A C   1 
ATOM   1745 O O   . GLY A 1 257 ? 10.521  2.152   2.998   1.00 36.83 ? 224 GLY A O   1 
ATOM   1746 N N   . GLU B 1 38  ? -2.533  -28.327 -57.984 1.00 42.32 ? 6   GLU B N   1 
ATOM   1747 C CA  . GLU B 1 38  ? -3.110  -27.021 -57.465 1.00 44.56 ? 6   GLU B CA  1 
ATOM   1748 C C   . GLU B 1 38  ? -3.721  -27.306 -56.075 1.00 36.33 ? 6   GLU B C   1 
ATOM   1749 O O   . GLU B 1 38  ? -4.844  -27.733 -56.015 1.00 34.87 ? 6   GLU B O   1 
ATOM   1750 C CB  . GLU B 1 38  ? -4.113  -26.494 -58.502 1.00 54.36 ? 6   GLU B CB  1 
ATOM   1751 C CG  . GLU B 1 38  ? -4.802  -25.204 -58.110 1.00 60.90 ? 6   GLU B CG  1 
ATOM   1752 C CD  . GLU B 1 38  ? -3.857  -24.018 -58.073 1.00 70.95 ? 6   GLU B CD  1 
ATOM   1753 O OE1 . GLU B 1 38  ? -3.736  -23.329 -59.108 1.00 71.42 ? 6   GLU B OE1 1 
ATOM   1754 O OE2 . GLU B 1 38  ? -3.233  -23.803 -57.013 1.00 81.11 ? 6   GLU B OE2 1 
ATOM   1755 N N   . VAL B 1 39  ? -2.999  -27.158 -54.974 1.00 29.07 ? 7   VAL B N   1 
ATOM   1756 C CA  . VAL B 1 39  ? -3.435  -27.792 -53.704 1.00 25.77 ? 7   VAL B CA  1 
ATOM   1757 C C   . VAL B 1 39  ? -4.549  -26.931 -53.089 1.00 21.71 ? 7   VAL B C   1 
ATOM   1758 O O   . VAL B 1 39  ? -5.398  -27.470 -52.364 1.00 20.24 ? 7   VAL B O   1 
ATOM   1759 C CB  . VAL B 1 39  ? -2.260  -28.053 -52.743 1.00 28.70 ? 7   VAL B CB  1 
ATOM   1760 C CG1 . VAL B 1 39  ? -1.182  -28.947 -53.380 1.00 32.11 ? 7   VAL B CG1 1 
ATOM   1761 C CG2 . VAL B 1 39  ? -1.636  -26.770 -52.210 1.00 28.42 ? 7   VAL B CG2 1 
ATOM   1762 N N   . ILE B 1 40  ? -4.572  -25.619 -53.326 1.00 18.12 ? 8   ILE B N   1 
ATOM   1763 C CA  . ILE B 1 40  ? -5.709  -24.812 -52.774 1.00 18.19 ? 8   ILE B CA  1 
ATOM   1764 C C   . ILE B 1 40  ? -6.789  -24.690 -53.853 1.00 16.92 ? 8   ILE B C   1 
ATOM   1765 O O   . ILE B 1 40  ? -6.584  -23.966 -54.882 1.00 16.12 ? 8   ILE B O   1 
ATOM   1766 C CB  . ILE B 1 40  ? -5.253  -23.441 -52.262 1.00 16.02 ? 8   ILE B CB  1 
ATOM   1767 C CG1 . ILE B 1 40  ? -4.234  -23.551 -51.135 1.00 16.02 ? 8   ILE B CG1 1 
ATOM   1768 C CG2 . ILE B 1 40  ? -6.452  -22.614 -51.786 1.00 18.47 ? 8   ILE B CG2 1 
ATOM   1769 C CD1 . ILE B 1 40  ? -3.653  -22.160 -50.768 1.00 16.89 ? 8   ILE B CD1 1 
ATOM   1770 N N   . LYS B 1 41  ? -7.901  -25.405 -53.650 1.00 18.52 ? 9   LYS B N   1 
ATOM   1771 C CA  . LYS B 1 41  ? -9.060  -25.449 -54.553 1.00 19.32 ? 9   LYS B CA  1 
ATOM   1772 C C   . LYS B 1 41  ? -9.889  -24.176 -54.383 1.00 16.96 ? 9   LYS B C   1 
ATOM   1773 O O   . LYS B 1 41  ? -9.722  -23.520 -53.353 1.00 16.98 ? 9   LYS B O   1 
ATOM   1774 C CB  . LYS B 1 41  ? -9.953  -26.640 -54.217 1.00 22.41 ? 9   LYS B CB  1 
ATOM   1775 C CG  . LYS B 1 41  ? -9.283  -28.010 -54.368 1.00 30.32 ? 9   LYS B CG  1 
ATOM   1776 C CD  . LYS B 1 41  ? -8.822  -28.263 -55.791 1.00 37.28 ? 9   LYS B CD  1 
ATOM   1777 C CE  . LYS B 1 41  ? -7.460  -28.927 -55.875 1.00 49.45 ? 9   LYS B CE  1 
ATOM   1778 N NZ  . LYS B 1 41  ? -7.578  -30.379 -56.121 1.00 51.77 ? 9   LYS B NZ  1 
ATOM   1779 N N   . GLU B 1 42  ? -10.794 -23.902 -55.304 1.00 16.48 ? 10  GLU B N   1 
ATOM   1780 C CA  . GLU B 1 42  ? -11.701 -22.727 -55.182 1.00 17.42 ? 10  GLU B CA  1 
ATOM   1781 C C   . GLU B 1 42  ? -12.624 -22.901 -53.959 1.00 15.61 ? 10  GLU B C   1 
ATOM   1782 O O   . GLU B 1 42  ? -13.134 -21.904 -53.469 1.00 16.35 ? 10  GLU B O   1 
ATOM   1783 C CB  . GLU B 1 42  ? -12.514 -22.525 -56.455 1.00 19.62 ? 10  GLU B CB  1 
ATOM   1784 C CG  . GLU B 1 42  ? -11.653 -21.988 -57.598 1.00 24.75 ? 10  GLU B CG  1 
ATOM   1785 C CD  . GLU B 1 42  ? -12.410 -21.545 -58.838 1.00 32.68 ? 10  GLU B CD  1 
ATOM   1786 O OE1 . GLU B 1 42  ? -12.522 -20.321 -59.055 1.00 38.88 ? 10  GLU B OE1 1 
ATOM   1787 O OE2 . GLU B 1 42  ? -12.894 -22.425 -59.577 1.00 36.53 ? 10  GLU B OE2 1 
ATOM   1788 N N   . PHE B 1 43  ? -12.855 -24.109 -53.482 1.00 13.91 ? 11  PHE B N   1 
ATOM   1789 C CA  . PHE B 1 43  ? -13.630 -24.376 -52.247 1.00 14.54 ? 11  PHE B CA  1 
ATOM   1790 C C   . PHE B 1 43  ? -12.724 -25.159 -51.323 1.00 13.66 ? 11  PHE B C   1 
ATOM   1791 O O   . PHE B 1 43  ? -12.175 -26.160 -51.757 1.00 15.40 ? 11  PHE B O   1 
ATOM   1792 C CB  . PHE B 1 43  ? -14.926 -25.143 -52.555 1.00 15.46 ? 11  PHE B CB  1 
ATOM   1793 C CG  . PHE B 1 43  ? -15.710 -25.557 -51.341 1.00 14.99 ? 11  PHE B CG  1 
ATOM   1794 C CD1 . PHE B 1 43  ? -16.502 -24.647 -50.662 1.00 15.66 ? 11  PHE B CD1 1 
ATOM   1795 C CD2 . PHE B 1 43  ? -15.626 -26.848 -50.866 1.00 15.36 ? 11  PHE B CD2 1 
ATOM   1796 C CE1 . PHE B 1 43  ? -17.198 -25.048 -49.548 1.00 15.60 ? 11  PHE B CE1 1 
ATOM   1797 C CE2 . PHE B 1 43  ? -16.310 -27.241 -49.743 1.00 17.22 ? 11  PHE B CE2 1 
ATOM   1798 C CZ  . PHE B 1 43  ? -17.096 -26.338 -49.088 1.00 17.72 ? 11  PHE B CZ  1 
ATOM   1799 N N   . MET B 1 44  ? -12.572 -24.733 -50.077 1.00 13.20 ? 12  MET B N   1 
ATOM   1800 C CA  . MET B 1 44  ? -11.680 -25.427 -49.130 1.00 13.72 ? 12  MET B CA  1 
ATOM   1801 C C   . MET B 1 44  ? -12.366 -25.434 -47.764 1.00 13.23 ? 12  MET B C   1 
ATOM   1802 O O   . MET B 1 44  ? -12.901 -24.357 -47.332 1.00 11.79 ? 12  MET B O   1 
ATOM   1803 C CB  . MET B 1 44  ? -10.304 -24.742 -48.997 1.00 12.07 ? 12  MET B CB  1 
ATOM   1804 C CG  . MET B 1 44  ? -9.478  -24.857 -50.261 1.00 12.85 ? 12  MET B CG  1 
ATOM   1805 S SD  . MET B 1 44  ? -8.926  -26.601 -50.530 1.00 14.67 ? 12  MET B SD  1 
ATOM   1806 C CE  . MET B 1 44  ? -7.725  -26.786 -49.204 1.00 16.25 ? 12  MET B CE  1 
ATOM   1807 N N   . ARG B 1 45  ? -12.305 -26.581 -47.106 1.00 13.13 ? 13  ARG B N   1 
ATOM   1808 C CA  . ARG B 1 45  ? -12.749 -26.720 -45.701 1.00 14.04 ? 13  ARG B CA  1 
ATOM   1809 C C   . ARG B 1 45  ? -11.549 -26.534 -44.764 1.00 15.49 ? 13  ARG B C   1 
ATOM   1810 O O   . ARG B 1 45  ? -10.378 -26.746 -45.192 1.00 14.69 ? 13  ARG B O   1 
ATOM   1811 C CB  . ARG B 1 45  ? -13.456 -28.056 -45.439 1.00 16.81 ? 13  ARG B CB  1 
ATOM   1812 C CG  . ARG B 1 45  ? -14.759 -28.208 -46.196 1.00 20.04 ? 13  ARG B CG  1 
ATOM   1813 C CD  . ARG B 1 45  ? -15.444 -29.517 -45.833 1.00 19.64 ? 13  ARG B CD  1 
ATOM   1814 N NE  . ARG B 1 45  ? -16.714 -29.517 -46.534 1.00 20.88 ? 13  ARG B NE  1 
ATOM   1815 C CZ  . ARG B 1 45  ? -17.865 -28.966 -46.084 1.00 21.03 ? 13  ARG B CZ  1 
ATOM   1816 N NH1 . ARG B 1 45  ? -17.931 -28.364 -44.909 1.00 20.22 ? 13  ARG B NH1 1 
ATOM   1817 N NH2 . ARG B 1 45  ? -18.928 -28.988 -46.865 1.00 24.13 ? 13  ARG B NH2 1 
ATOM   1818 N N   . PHE B 1 46  ? -11.814 -26.256 -43.482 1.00 13.94 ? 14  PHE B N   1 
ATOM   1819 C CA  . PHE B 1 46  ? -10.742 -26.276 -42.459 1.00 14.28 ? 14  PHE B CA  1 
ATOM   1820 C C   . PHE B 1 46  ? -11.263 -26.850 -41.149 1.00 13.65 ? 14  PHE B C   1 
ATOM   1821 O O   . PHE B 1 46  ? -12.507 -26.842 -40.964 1.00 13.60 ? 14  PHE B O   1 
ATOM   1822 C CB  . PHE B 1 46  ? -10.191 -24.865 -42.209 1.00 12.42 ? 14  PHE B CB  1 
ATOM   1823 C CG  . PHE B 1 46  ? -11.045 -23.834 -41.503 1.00 12.88 ? 14  PHE B CG  1 
ATOM   1824 C CD1 . PHE B 1 46  ? -11.094 -23.780 -40.115 1.00 13.34 ? 14  PHE B CD1 1 
ATOM   1825 C CD2 . PHE B 1 46  ? -11.657 -22.819 -42.226 1.00 13.10 ? 14  PHE B CD2 1 
ATOM   1826 C CE1 . PHE B 1 46  ? -11.806 -22.784 -39.464 1.00 12.56 ? 14  PHE B CE1 1 
ATOM   1827 C CE2 . PHE B 1 46  ? -12.380 -21.837 -41.577 1.00 12.28 ? 14  PHE B CE2 1 
ATOM   1828 C CZ  . PHE B 1 46  ? -12.408 -21.793 -40.209 1.00 12.64 ? 14  PHE B CZ  1 
ATOM   1829 N N   . LYS B 1 47  ? -10.361 -27.385 -40.352 1.00 14.45 ? 15  LYS B N   1 
ATOM   1830 C CA  . LYS B 1 47  ? -10.667 -27.844 -38.989 1.00 17.48 ? 15  LYS B CA  1 
ATOM   1831 C C   . LYS B 1 47  ? -9.768  -27.071 -38.041 1.00 16.49 ? 15  LYS B C   1 
ATOM   1832 O O   . LYS B 1 47  ? -8.605  -26.834 -38.395 1.00 15.94 ? 15  LYS B O   1 
ATOM   1833 C CB  . LYS B 1 47  ? -10.444 -29.357 -38.889 1.00 21.20 ? 15  LYS B CB  1 
ATOM   1834 C CG  . LYS B 1 47  ? -11.200 -30.216 -39.897 1.00 26.17 ? 15  LYS B CG  1 
ATOM   1835 C CD  . LYS B 1 47  ? -12.716 -30.220 -39.695 1.00 34.94 ? 15  LYS B CD  1 
ATOM   1836 C CE  . LYS B 1 47  ? -13.507 -31.136 -40.630 1.00 37.89 ? 15  LYS B CE  1 
ATOM   1837 N NZ  . LYS B 1 47  ? -14.050 -30.375 -41.798 1.00 40.78 ? 15  LYS B NZ  1 
ATOM   1838 N N   . GLU B 1 48  ? -10.287 -26.718 -36.882 1.00 17.02 ? 16  GLU B N   1 
ATOM   1839 C CA  . GLU B 1 48  ? -9.558  -25.874 -35.937 1.00 15.52 ? 16  GLU B CA  1 
ATOM   1840 C C   . GLU B 1 48  ? -9.659  -26.482 -34.556 1.00 16.50 ? 16  GLU B C   1 
ATOM   1841 O O   . GLU B 1 48  ? -10.784 -26.776 -34.125 1.00 15.49 ? 16  GLU B O   1 
ATOM   1842 C CB  . GLU B 1 48  ? -10.082 -24.445 -36.030 1.00 17.84 ? 16  GLU B CB  1 
ATOM   1843 C CG  . GLU B 1 48  ? -9.320  -23.524 -35.106 1.00 16.88 ? 16  GLU B CG  1 
ATOM   1844 C CD  . GLU B 1 48  ? -9.470  -22.047 -35.322 1.00 18.70 ? 16  GLU B CD  1 
ATOM   1845 O OE1 . GLU B 1 48  ? -9.724  -21.664 -36.484 1.00 19.48 ? 16  GLU B OE1 1 
ATOM   1846 O OE2 . GLU B 1 48  ? -9.422  -21.314 -34.283 1.00 18.33 ? 16  GLU B OE2 1 
ATOM   1847 N N   . HIS B 1 49  ? -8.533  -26.458 -33.848 1.00 16.25 ? 17  HIS B N   1 
ATOM   1848 C CA  . HIS B 1 49  ? -8.423  -26.688 -32.400 1.00 17.25 ? 17  HIS B CA  1 
ATOM   1849 C C   . HIS B 1 49  ? -7.746  -25.469 -31.769 1.00 17.45 ? 17  HIS B C   1 
ATOM   1850 O O   . HIS B 1 49  ? -6.651  -25.022 -32.288 1.00 18.60 ? 17  HIS B O   1 
ATOM   1851 C CB  . HIS B 1 49  ? -7.671  -27.987 -32.111 1.00 20.37 ? 17  HIS B CB  1 
ATOM   1852 C CG  . HIS B 1 49  ? -7.509  -28.155 -30.636 1.00 24.16 ? 17  HIS B CG  1 
ATOM   1853 N ND1 . HIS B 1 49  ? -6.372  -27.668 -29.930 1.00 26.67 ? 17  HIS B ND1 1 
ATOM   1854 C CD2 . HIS B 1 49  ? -8.410  -28.554 -29.702 1.00 30.26 ? 17  HIS B CD2 1 
ATOM   1855 C CE1 . HIS B 1 49  ? -6.548  -27.869 -28.640 1.00 25.14 ? 17  HIS B CE1 1 
ATOM   1856 N NE2 . HIS B 1 49  ? -7.799  -28.431 -28.473 1.00 31.65 ? 17  HIS B NE2 1 
ATOM   1857 N N   . MET B 1 50  ? -8.408  -24.903 -30.770 1.00 14.99 ? 18  MET B N   1 
ATOM   1858 C CA  . MET B 1 50  ? -7.913  -23.735 -29.990 1.00 14.09 ? 18  MET B CA  1 
ATOM   1859 C C   . MET B 1 50  ? -7.901  -24.133 -28.514 1.00 16.85 ? 18  MET B C   1 
ATOM   1860 O O   . MET B 1 50  ? -8.932  -24.698 -28.018 1.00 16.14 ? 18  MET B O   1 
ATOM   1861 C CB  . MET B 1 50  ? -8.838  -22.554 -30.173 1.00 15.07 ? 18  MET B CB  1 
ATOM   1862 C CG  . MET B 1 50  ? -8.463  -21.389 -29.295 1.00 16.73 ? 18  MET B CG  1 
ATOM   1863 S SD  . MET B 1 50  ? -9.512  -19.955 -29.574 1.00 17.15 ? 18  MET B SD  1 
ATOM   1864 C CE  . MET B 1 50  ? -8.913  -19.450 -31.189 1.00 14.03 ? 18  MET B CE  1 
ATOM   1865 N N   . GLU B 1 51  ? -6.808  -23.833 -27.826 1.00 16.74 ? 19  GLU B N   1 
ATOM   1866 C CA  . GLU B 1 51  ? -6.717  -23.997 -26.370 1.00 18.94 ? 19  GLU B CA  1 
ATOM   1867 C C   . GLU B 1 51  ? -6.119  -22.726 -25.826 1.00 17.48 ? 19  GLU B C   1 
ATOM   1868 O O   . GLU B 1 51  ? -5.450  -21.966 -26.587 1.00 15.81 ? 19  GLU B O   1 
ATOM   1869 C CB  . GLU B 1 51  ? -5.858  -25.187 -25.959 1.00 22.60 ? 19  GLU B CB  1 
ATOM   1870 C CG  . GLU B 1 51  ? -4.459  -25.115 -26.502 1.00 26.03 ? 19  GLU B CG  1 
ATOM   1871 C CD  . GLU B 1 51  ? -3.624  -26.355 -26.298 1.00 30.59 ? 19  GLU B CD  1 
ATOM   1872 O OE1 . GLU B 1 51  ? -2.378  -26.220 -26.292 1.00 36.55 ? 19  GLU B OE1 1 
ATOM   1873 O OE2 . GLU B 1 51  ? -4.213  -27.405 -26.215 1.00 35.82 ? 19  GLU B OE2 1 
ATOM   1874 N N   . GLY B 1 52  ? -6.346  -22.495 -24.557 1.00 15.79 ? 20  GLY B N   1 
ATOM   1875 C CA  . GLY B 1 52  ? -5.744  -21.310 -23.940 1.00 19.09 ? 20  GLY B CA  1 
ATOM   1876 C C   . GLY B 1 52  ? -6.348  -20.996 -22.590 1.00 18.76 ? 20  GLY B C   1 
ATOM   1877 O O   . GLY B 1 52  ? -7.084  -21.856 -22.025 1.00 17.30 ? 20  GLY B O   1 
ATOM   1878 N N   . SER B 1 53  ? -6.130  -19.740 -22.167 1.00 17.13 ? 21  SER B N   1 
ATOM   1879 C CA  . SER B 1 53  ? -6.679  -19.191 -20.924 1.00 15.78 ? 21  SER B CA  1 
ATOM   1880 C C   . SER B 1 53  ? -6.787  -17.691 -21.103 1.00 18.12 ? 21  SER B C   1 
ATOM   1881 O O   . SER B 1 53  ? -5.920  -17.070 -21.802 1.00 16.71 ? 21  SER B O   1 
ATOM   1882 C CB  . SER B 1 53  ? -5.816  -19.526 -19.715 1.00 16.39 ? 21  SER B CB  1 
ATOM   1883 O OG  . SER B 1 53  ? -4.468  -19.131 -19.900 1.00 18.10 ? 21  SER B OG  1 
ATOM   1884 N N   . VAL B 1 54  ? -7.764  -17.134 -20.428 1.00 17.59 ? 22  VAL B N   1 
ATOM   1885 C CA  . VAL B 1 54  ? -7.929  -15.679 -20.302 1.00 16.63 ? 22  VAL B CA  1 
ATOM   1886 C C   . VAL B 1 54  ? -8.230  -15.369 -18.822 1.00 16.36 ? 22  VAL B C   1 
ATOM   1887 O O   . VAL B 1 54  ? -9.168  -15.947 -18.242 1.00 15.97 ? 22  VAL B O   1 
ATOM   1888 C CB  . VAL B 1 54  ? -9.049  -15.175 -21.234 1.00 19.76 ? 22  VAL B CB  1 
ATOM   1889 C CG1 . VAL B 1 54  ? -9.326  -13.715 -20.930 1.00 19.26 ? 22  VAL B CG1 1 
ATOM   1890 C CG2 . VAL B 1 54  ? -8.688  -15.351 -22.699 1.00 18.41 ? 22  VAL B CG2 1 
ATOM   1891 N N   . ASN B 1 55  ? -7.464  -14.486 -18.206 1.00 16.51 ? 23  ASN B N   1 
ATOM   1892 C CA  . ASN B 1 55  ? -7.641  -14.163 -16.759 1.00 17.40 ? 23  ASN B CA  1 
ATOM   1893 C C   . ASN B 1 55  ? -7.753  -15.473 -15.959 1.00 15.44 ? 23  ASN B C   1 
ATOM   1894 O O   . ASN B 1 55  ? -8.608  -15.565 -15.093 1.00 16.08 ? 23  ASN B O   1 
ATOM   1895 C CB  . ASN B 1 55  ? -8.825  -13.218 -16.583 1.00 17.59 ? 23  ASN B CB  1 
ATOM   1896 C CG  . ASN B 1 55  ? -8.455  -11.771 -16.823 1.00 18.93 ? 23  ASN B CG  1 
ATOM   1897 O OD1 . ASN B 1 55  ? -7.532  -11.485 -17.573 1.00 18.69 ? 23  ASN B OD1 1 
ATOM   1898 N ND2 . ASN B 1 55  ? -9.118  -10.844 -16.162 1.00 19.27 ? 23  ASN B ND2 1 
ATOM   1899 N N   . GLY B 1 56  ? -6.915  -16.466 -16.245 1.00 17.49 ? 24  GLY B N   1 
ATOM   1900 C CA  . GLY B 1 56  ? -6.827  -17.710 -15.457 1.00 19.60 ? 24  GLY B CA  1 
ATOM   1901 C C   . GLY B 1 56  ? -7.828  -18.767 -15.884 1.00 20.67 ? 24  GLY B C   1 
ATOM   1902 O O   . GLY B 1 56  ? -7.771  -19.896 -15.392 1.00 20.07 ? 24  GLY B O   1 
ATOM   1903 N N   . HIS B 1 57  ? -8.759  -18.400 -16.750 1.00 18.53 ? 25  HIS B N   1 
ATOM   1904 C CA  . HIS B 1 57  ? -9.862  -19.290 -17.127 1.00 19.45 ? 25  HIS B CA  1 
ATOM   1905 C C   . HIS B 1 57  ? -9.393  -20.119 -18.315 1.00 18.69 ? 25  HIS B C   1 
ATOM   1906 O O   . HIS B 1 57  ? -9.326  -19.552 -19.428 1.00 17.99 ? 25  HIS B O   1 
ATOM   1907 C CB  . HIS B 1 57  ? -11.160 -18.521 -17.417 1.00 19.49 ? 25  HIS B CB  1 
ATOM   1908 C CG  . HIS B 1 57  ? -12.270 -19.495 -17.614 1.00 20.74 ? 25  HIS B CG  1 
ATOM   1909 N ND1 . HIS B 1 57  ? -13.067 -19.930 -16.560 1.00 22.72 ? 25  HIS B ND1 1 
ATOM   1910 C CD2 . HIS B 1 57  ? -12.691 -20.170 -18.713 1.00 19.84 ? 25  HIS B CD2 1 
ATOM   1911 C CE1 . HIS B 1 57  ? -13.965 -20.788 -17.013 1.00 22.44 ? 25  HIS B CE1 1 
ATOM   1912 N NE2 . HIS B 1 57  ? -13.735 -21.000 -18.331 1.00 20.33 ? 25  HIS B NE2 1 
ATOM   1913 N N   . GLU B 1 58  ? -9.164  -21.409 -18.106 1.00 19.16 ? 26  GLU B N   1 
ATOM   1914 C CA  . GLU B 1 58  ? -8.752  -22.315 -19.209 1.00 19.91 ? 26  GLU B CA  1 
ATOM   1915 C C   . GLU B 1 58  ? -9.946  -22.730 -20.076 1.00 17.04 ? 26  GLU B C   1 
ATOM   1916 O O   . GLU B 1 58  ? -11.035 -23.005 -19.560 1.00 17.74 ? 26  GLU B O   1 
ATOM   1917 C CB  . GLU B 1 58  ? -8.095  -23.570 -18.665 1.00 20.73 ? 26  GLU B CB  1 
ATOM   1918 C CG  . GLU B 1 58  ? -6.761  -23.267 -18.021 1.00 27.04 ? 26  GLU B CG  1 
ATOM   1919 C CD  . GLU B 1 58  ? -6.039  -24.447 -17.409 1.00 37.49 ? 26  GLU B CD  1 
ATOM   1920 O OE1 . GLU B 1 58  ? -6.577  -25.618 -17.379 1.00 44.36 ? 26  GLU B OE1 1 
ATOM   1921 O OE2 . GLU B 1 58  ? -4.962  -24.196 -16.929 1.00 44.55 ? 26  GLU B OE2 1 
ATOM   1922 N N   . PHE B 1 59  ? -9.715  -22.982 -21.350 1.00 17.65 ? 27  PHE B N   1 
ATOM   1923 C CA  . PHE B 1 59  ? -10.785 -23.442 -22.268 1.00 16.21 ? 27  PHE B CA  1 
ATOM   1924 C C   . PHE B 1 59  ? -10.191 -24.127 -23.476 1.00 16.49 ? 27  PHE B C   1 
ATOM   1925 O O   . PHE B 1 59  ? -8.942  -23.996 -23.742 1.00 15.69 ? 27  PHE B O   1 
ATOM   1926 C CB  . PHE B 1 59  ? -11.634 -22.258 -22.718 1.00 15.38 ? 27  PHE B CB  1 
ATOM   1927 C CG  . PHE B 1 59  ? -10.837 -21.260 -23.533 1.00 15.32 ? 27  PHE B CG  1 
ATOM   1928 C CD1 . PHE B 1 59  ? -10.070 -20.314 -22.897 1.00 17.09 ? 27  PHE B CD1 1 
ATOM   1929 C CD2 . PHE B 1 59  ? -10.775 -21.343 -24.905 1.00 17.57 ? 27  PHE B CD2 1 
ATOM   1930 C CE1 . PHE B 1 59  ? -9.340  -19.375 -23.608 1.00 19.99 ? 27  PHE B CE1 1 
ATOM   1931 C CE2 . PHE B 1 59  ? -10.019 -20.427 -25.633 1.00 19.67 ? 27  PHE B CE2 1 
ATOM   1932 C CZ  . PHE B 1 59  ? -9.294  -19.447 -24.981 1.00 19.28 ? 27  PHE B CZ  1 
ATOM   1933 N N   . GLU B 1 60  ? -11.052 -24.900 -24.151 1.00 17.06 ? 28  GLU B N   1 
ATOM   1934 C CA  . GLU B 1 60  ? -10.777 -25.476 -25.489 1.00 18.24 ? 28  GLU B CA  1 
ATOM   1935 C C   . GLU B 1 60  ? -11.993 -25.233 -26.385 1.00 17.29 ? 28  GLU B C   1 
ATOM   1936 O O   . GLU B 1 60  ? -13.117 -25.203 -25.849 1.00 17.13 ? 28  GLU B O   1 
ATOM   1937 C CB  . GLU B 1 60  ? -10.443 -26.962 -25.416 1.00 20.70 ? 28  GLU B CB  1 
ATOM   1938 C CG  . GLU B 1 60  ? -9.169  -27.249 -24.632 1.00 22.82 ? 28  GLU B CG  1 
ATOM   1939 C CD  . GLU B 1 60  ? -8.700  -28.694 -24.757 1.00 26.71 ? 28  GLU B CD  1 
ATOM   1940 O OE1 . GLU B 1 60  ? -9.200  -29.434 -25.663 1.00 31.47 ? 28  GLU B OE1 1 
ATOM   1941 O OE2 . GLU B 1 60  ? -7.803  -29.065 -23.991 1.00 29.72 ? 28  GLU B OE2 1 
ATOM   1942 N N   . ILE B 1 61  ? -11.729 -25.032 -27.683 1.00 16.32 ? 29  ILE B N   1 
ATOM   1943 C CA  . ILE B 1 61  ? -12.710 -24.766 -28.744 1.00 16.56 ? 29  ILE B CA  1 
ATOM   1944 C C   . ILE B 1 61  ? -12.354 -25.688 -29.911 1.00 17.12 ? 29  ILE B C   1 
ATOM   1945 O O   . ILE B 1 61  ? -11.137 -25.862 -30.227 1.00 16.02 ? 29  ILE B O   1 
ATOM   1946 C CB  . ILE B 1 61  ? -12.703 -23.265 -29.128 1.00 17.28 ? 29  ILE B CB  1 
ATOM   1947 C CG1 . ILE B 1 61  ? -13.334 -22.426 -28.026 1.00 18.76 ? 29  ILE B CG1 1 
ATOM   1948 C CG2 . ILE B 1 61  ? -13.378 -23.058 -30.478 1.00 17.64 ? 29  ILE B CG2 1 
ATOM   1949 C CD1 . ILE B 1 61  ? -13.167 -20.941 -28.162 1.00 17.96 ? 29  ILE B CD1 1 
ATOM   1950 N N   . GLU B 1 62  ? -13.352 -26.293 -30.506 1.00 15.74 ? 30  GLU B N   1 
ATOM   1951 C CA  . GLU B 1 62  ? -13.185 -27.008 -31.792 1.00 17.64 ? 30  GLU B CA  1 
ATOM   1952 C C   . GLU B 1 62  ? -14.030 -26.368 -32.871 1.00 16.85 ? 30  GLU B C   1 
ATOM   1953 O O   . GLU B 1 62  ? -15.107 -25.896 -32.584 1.00 18.24 ? 30  GLU B O   1 
ATOM   1954 C CB  . GLU B 1 62  ? -13.578 -28.475 -31.682 1.00 22.85 ? 30  GLU B CB  1 
ATOM   1955 C CG  . GLU B 1 62  ? -12.396 -29.303 -31.235 1.00 27.07 ? 30  GLU B CG  1 
ATOM   1956 C CD  . GLU B 1 62  ? -12.735 -30.703 -30.787 1.00 33.41 ? 30  GLU B CD  1 
ATOM   1957 O OE1 . GLU B 1 62  ? -11.868 -31.278 -30.070 1.00 35.47 ? 30  GLU B OE1 1 
ATOM   1958 O OE2 . GLU B 1 62  ? -13.878 -31.186 -31.128 1.00 39.81 ? 30  GLU B OE2 1 
ATOM   1959 N N   . GLY B 1 63  ? -13.536 -26.338 -34.089 1.00 15.69 ? 31  GLY B N   1 
ATOM   1960 C CA  . GLY B 1 63  ? -14.292 -25.682 -35.165 1.00 17.75 ? 31  GLY B CA  1 
ATOM   1961 C C   . GLY B 1 63  ? -14.182 -26.436 -36.444 1.00 16.15 ? 31  GLY B C   1 
ATOM   1962 O O   . GLY B 1 63  ? -13.169 -27.049 -36.670 1.00 16.45 ? 31  GLY B O   1 
ATOM   1963 N N   . GLU B 1 64  ? -15.171 -26.282 -37.290 1.00 14.84 ? 32  GLU B N   1 
ATOM   1964 C CA  . GLU B 1 64  ? -15.051 -26.674 -38.707 1.00 15.12 ? 32  GLU B CA  1 
ATOM   1965 C C   . GLU B 1 64  ? -15.570 -25.529 -39.563 1.00 14.19 ? 32  GLU B C   1 
ATOM   1966 O O   . GLU B 1 64  ? -16.603 -24.929 -39.206 1.00 15.09 ? 32  GLU B O   1 
ATOM   1967 C CB  . GLU B 1 64  ? -15.765 -27.977 -38.994 1.00 14.27 ? 32  GLU B CB  1 
ATOM   1968 C CG  . GLU B 1 64  ? -17.266 -27.980 -38.787 1.00 14.61 ? 32  GLU B CG  1 
ATOM   1969 C CD  . GLU B 1 64  ? -18.172 -27.349 -39.837 1.00 14.08 ? 32  GLU B CD  1 
ATOM   1970 O OE1 . GLU B 1 64  ? -17.741 -27.087 -40.981 1.00 15.73 ? 32  GLU B OE1 1 
ATOM   1971 O OE2 . GLU B 1 64  ? -19.340 -27.036 -39.437 1.00 16.86 ? 32  GLU B OE2 1 
ATOM   1972 N N   . GLY B 1 65  ? -14.912 -25.287 -40.691 1.00 13.79 ? 33  GLY B N   1 
ATOM   1973 C CA  . GLY B 1 65  ? -15.226 -24.135 -41.544 1.00 12.27 ? 33  GLY B CA  1 
ATOM   1974 C C   . GLY B 1 65  ? -15.144 -24.464 -43.015 1.00 12.73 ? 33  GLY B C   1 
ATOM   1975 O O   . GLY B 1 65  ? -14.688 -25.580 -43.379 1.00 11.09 ? 33  GLY B O   1 
ATOM   1976 N N   . GLU B 1 66  ? -15.553 -23.535 -43.851 1.00 10.93 ? 34  GLU B N   1 
ATOM   1977 C CA  . GLU B 1 66  ? -15.507 -23.687 -45.331 1.00 11.59 ? 34  GLU B CA  1 
ATOM   1978 C C   . GLU B 1 66  ? -15.430 -22.286 -45.916 1.00 12.76 ? 34  GLU B C   1 
ATOM   1979 O O   . GLU B 1 66  ? -15.943 -21.291 -45.303 1.00 11.86 ? 34  GLU B O   1 
ATOM   1980 C CB  . GLU B 1 66  ? -16.696 -24.443 -45.929 1.00 12.52 ? 34  GLU B CB  1 
ATOM   1981 C CG  . GLU B 1 66  ? -18.041 -23.739 -45.769 1.00 12.75 ? 34  GLU B CG  1 
ATOM   1982 C CD  . GLU B 1 66  ? -19.238 -24.641 -45.681 1.00 13.24 ? 34  GLU B CD  1 
ATOM   1983 O OE1 . GLU B 1 66  ? -19.572 -25.044 -44.527 1.00 15.78 ? 34  GLU B OE1 1 
ATOM   1984 O OE2 . GLU B 1 66  ? -19.858 -24.960 -46.758 1.00 13.22 ? 34  GLU B OE2 1 
ATOM   1985 N N   . GLY B 1 67  ? -14.898 -22.185 -47.114 1.00 11.51 ? 35  GLY B N   1 
ATOM   1986 C CA  . GLY B 1 67  ? -14.889 -20.892 -47.801 1.00 11.10 ? 35  GLY B CA  1 
ATOM   1987 C C   . GLY B 1 67  ? -14.280 -21.006 -49.166 1.00 11.18 ? 35  GLY B C   1 
ATOM   1988 O O   . GLY B 1 67  ? -13.938 -22.152 -49.644 1.00 10.97 ? 35  GLY B O   1 
ATOM   1989 N N   . ARG B 1 68  ? -14.044 -19.844 -49.753 1.00 12.22 ? 36  ARG B N   1 
ATOM   1990 C CA  . ARG B 1 68  ? -13.520 -19.725 -51.116 1.00 12.08 ? 36  ARG B CA  1 
ATOM   1991 C C   . ARG B 1 68  ? -12.262 -18.885 -51.030 1.00 11.74 ? 36  ARG B C   1 
ATOM   1992 O O   . ARG B 1 68  ? -12.303 -17.653 -50.991 1.00 12.45 ? 36  ARG B O   1 
ATOM   1993 C CB  . ARG B 1 68  ? -14.612 -19.123 -51.996 1.00 13.10 ? 36  ARG B CB  1 
ATOM   1994 C CG  . ARG B 1 68  ? -15.882 -19.965 -52.008 1.00 14.33 ? 36  ARG B CG  1 
ATOM   1995 C CD  . ARG B 1 68  ? -17.068 -19.252 -52.553 1.00 15.96 ? 36  ARG B CD  1 
ATOM   1996 N NE  . ARG B 1 68  ? -18.287 -20.056 -52.414 1.00 16.71 ? 36  ARG B NE  1 
ATOM   1997 C CZ  . ARG B 1 68  ? -19.521 -19.643 -52.596 1.00 17.53 ? 36  ARG B CZ  1 
ATOM   1998 N NH1 . ARG B 1 68  ? -19.774 -18.383 -52.958 1.00 17.74 ? 36  ARG B NH1 1 
ATOM   1999 N NH2 . ARG B 1 68  ? -20.498 -20.531 -52.426 1.00 18.81 ? 36  ARG B NH2 1 
ATOM   2000 N N   . PRO B 1 69  ? -11.081 -19.525 -50.993 1.00 12.66 ? 37  PRO B N   1 
ATOM   2001 C CA  . PRO B 1 69  ? -9.845  -18.803 -50.685 1.00 11.97 ? 37  PRO B CA  1 
ATOM   2002 C C   . PRO B 1 69  ? -9.497  -17.650 -51.640 1.00 12.15 ? 37  PRO B C   1 
ATOM   2003 O O   . PRO B 1 69  ? -8.954  -16.648 -51.204 1.00 14.10 ? 37  PRO B O   1 
ATOM   2004 C CB  . PRO B 1 69  ? -8.773  -19.910 -50.706 1.00 12.66 ? 37  PRO B CB  1 
ATOM   2005 C CG  . PRO B 1 69  ? -9.537  -21.171 -50.434 1.00 12.29 ? 37  PRO B CG  1 
ATOM   2006 C CD  . PRO B 1 69  ? -10.910 -20.973 -51.069 1.00 12.81 ? 37  PRO B CD  1 
ATOM   2007 N N   . TYR B 1 70  ? -9.868  -17.757 -52.911 1.00 13.17 ? 38  TYR B N   1 
ATOM   2008 C CA  . TYR B 1 70  ? -9.567  -16.767 -53.961 1.00 14.09 ? 38  TYR B CA  1 
ATOM   2009 C C   . TYR B 1 70  ? -10.603 -15.654 -53.908 1.00 14.52 ? 38  TYR B C   1 
ATOM   2010 O O   . TYR B 1 70  ? -10.397 -14.623 -54.522 1.00 15.75 ? 38  TYR B O   1 
ATOM   2011 C CB  . TYR B 1 70  ? -9.449  -17.453 -55.322 1.00 14.73 ? 38  TYR B CB  1 
ATOM   2012 C CG  . TYR B 1 70  ? -8.391  -18.519 -55.352 1.00 15.06 ? 38  TYR B CG  1 
ATOM   2013 C CD1 . TYR B 1 70  ? -7.031  -18.225 -55.537 1.00 15.35 ? 38  TYR B CD1 1 
ATOM   2014 C CD2 . TYR B 1 70  ? -8.761  -19.826 -55.133 1.00 16.93 ? 38  TYR B CD2 1 
ATOM   2015 C CE1 . TYR B 1 70  ? -6.074  -19.230 -55.597 1.00 17.14 ? 38  TYR B CE1 1 
ATOM   2016 C CE2 . TYR B 1 70  ? -7.810  -20.834 -55.125 1.00 18.22 ? 38  TYR B CE2 1 
ATOM   2017 C CZ  . TYR B 1 70  ? -6.482  -20.546 -55.375 1.00 17.95 ? 38  TYR B CZ  1 
ATOM   2018 O OH  . TYR B 1 70  ? -5.597  -21.585 -55.346 1.00 18.29 ? 38  TYR B OH  1 
ATOM   2019 N N   . GLU B 1 71  ? -11.714 -15.873 -53.205 1.00 14.80 ? 39  GLU B N   1 
ATOM   2020 C CA  . GLU B 1 71  ? -12.745 -14.798 -53.083 1.00 15.78 ? 39  GLU B CA  1 
ATOM   2021 C C   . GLU B 1 71  ? -12.600 -14.109 -51.731 1.00 15.62 ? 39  GLU B C   1 
ATOM   2022 O O   . GLU B 1 71  ? -13.272 -13.153 -51.520 1.00 16.73 ? 39  GLU B O   1 
ATOM   2023 C CB  . GLU B 1 71  ? -14.160 -15.359 -53.223 1.00 16.74 ? 39  GLU B CB  1 
ATOM   2024 C CG  . GLU B 1 71  ? -14.416 -16.030 -54.551 1.00 21.61 ? 39  GLU B CG  1 
ATOM   2025 C CD  . GLU B 1 71  ? -14.137 -15.226 -55.806 1.00 29.32 ? 39  GLU B CD  1 
ATOM   2026 O OE1 . GLU B 1 71  ? -14.082 -13.924 -55.785 1.00 35.89 ? 39  GLU B OE1 1 
ATOM   2027 O OE2 . GLU B 1 71  ? -13.888 -15.905 -56.807 1.00 36.92 ? 39  GLU B OE2 1 
ATOM   2028 N N   . GLY B 1 72  ? -11.794 -14.643 -50.832 1.00 14.33 ? 40  GLY B N   1 
ATOM   2029 C CA  . GLY B 1 72  ? -11.576 -13.996 -49.533 1.00 14.88 ? 40  GLY B CA  1 
ATOM   2030 C C   . GLY B 1 72  ? -12.710 -14.272 -48.573 1.00 12.66 ? 40  GLY B C   1 
ATOM   2031 O O   . GLY B 1 72  ? -12.849 -13.478 -47.586 1.00 12.52 ? 40  GLY B O   1 
ATOM   2032 N N   . THR B 1 73  ? -13.519 -15.325 -48.761 1.00 12.23 ? 41  THR B N   1 
ATOM   2033 C CA  . THR B 1 73  ? -14.732 -15.492 -47.908 1.00 11.59 ? 41  THR B CA  1 
ATOM   2034 C C   . THR B 1 73  ? -14.706 -16.837 -47.202 1.00 12.22 ? 41  THR B C   1 
ATOM   2035 O O   . THR B 1 73  ? -14.233 -17.839 -47.790 1.00 12.66 ? 41  THR B O   1 
ATOM   2036 C CB  . THR B 1 73  ? -15.977 -15.294 -48.754 1.00 13.40 ? 41  THR B CB  1 
ATOM   2037 O OG1 . THR B 1 73  ? -15.925 -16.243 -49.834 1.00 12.57 ? 41  THR B OG1 1 
ATOM   2038 C CG2 . THR B 1 73  ? -16.063 -13.880 -49.296 1.00 11.76 ? 41  THR B CG2 1 
ATOM   2039 N N   . GLN B 1 74  ? -15.242 -16.868 -45.992 1.00 11.80 ? 42  GLN B N   1 
ATOM   2040 C CA  . GLN B 1 74  ? -15.304 -18.109 -45.209 1.00 11.66 ? 42  GLN B CA  1 
ATOM   2041 C C   . GLN B 1 74  ? -16.328 -18.001 -44.078 1.00 12.92 ? 42  GLN B C   1 
ATOM   2042 O O   . GLN B 1 74  ? -16.611 -16.893 -43.591 1.00 12.44 ? 42  GLN B O   1 
ATOM   2043 C CB  . GLN B 1 74  ? -13.922 -18.443 -44.633 1.00 12.71 ? 42  GLN B CB  1 
ATOM   2044 C CG  . GLN B 1 74  ? -13.421 -17.400 -43.656 1.00 12.64 ? 42  GLN B CG  1 
ATOM   2045 C CD  . GLN B 1 74  ? -12.001 -17.675 -43.219 1.00 12.13 ? 42  GLN B CD  1 
ATOM   2046 O OE1 . GLN B 1 74  ? -11.725 -18.734 -42.702 1.00 13.22 ? 42  GLN B OE1 1 
ATOM   2047 N NE2 . GLN B 1 74  ? -11.089 -16.741 -43.465 1.00 12.45 ? 42  GLN B NE2 1 
ATOM   2048 N N   . THR B 1 75  ? -16.819 -19.166 -43.690 1.00 13.01 ? 43  THR B N   1 
ATOM   2049 C CA  . THR B 1 75  ? -17.680 -19.376 -42.521 1.00 13.21 ? 43  THR B CA  1 
ATOM   2050 C C   . THR B 1 75  ? -17.137 -20.499 -41.666 1.00 13.64 ? 43  THR B C   1 
ATOM   2051 O O   . THR B 1 75  ? -16.431 -21.353 -42.168 1.00 15.68 ? 43  THR B O   1 
ATOM   2052 C CB  . THR B 1 75  ? -19.133 -19.637 -42.934 1.00 13.70 ? 43  THR B CB  1 
ATOM   2053 O OG1 . THR B 1 75  ? -19.171 -20.871 -43.661 1.00 13.49 ? 43  THR B OG1 1 
ATOM   2054 C CG2 . THR B 1 75  ? -19.705 -18.458 -43.673 1.00 13.35 ? 43  THR B CG2 1 
ATOM   2055 N N   . ALA B 1 76  ? -17.493 -20.491 -40.396 1.00 15.20 ? 44  ALA B N   1 
ATOM   2056 C CA  . ALA B 1 76  ? -17.162 -21.591 -39.485 1.00 14.27 ? 44  ALA B CA  1 
ATOM   2057 C C   . ALA B 1 76  ? -18.215 -21.744 -38.369 1.00 14.02 ? 44  ALA B C   1 
ATOM   2058 O O   . ALA B 1 76  ? -18.875 -20.738 -37.973 1.00 13.59 ? 44  ALA B O   1 
ATOM   2059 C CB  . ALA B 1 76  ? -15.775 -21.349 -38.914 1.00 15.13 ? 44  ALA B CB  1 
ATOM   2060 N N   . ARG B 1 77  ? -18.338 -22.993 -37.921 1.00 13.59 ? 45  ARG B N   1 
ATOM   2061 C CA  . ARG B 1 77  ? -19.120 -23.455 -36.743 1.00 13.98 ? 45  ARG B CA  1 
ATOM   2062 C C   . ARG B 1 77  ? -18.124 -23.763 -35.630 1.00 14.04 ? 45  ARG B C   1 
ATOM   2063 O O   . ARG B 1 77  ? -17.244 -24.635 -35.804 1.00 11.57 ? 45  ARG B O   1 
ATOM   2064 C CB  . ARG B 1 77  ? -19.972 -24.689 -37.116 1.00 14.88 ? 45  ARG B CB  1 
ATOM   2065 C CG  . ARG B 1 77  ? -21.258 -24.418 -37.878 1.00 14.69 ? 45  ARG B CG  1 
ATOM   2066 C CD  . ARG B 1 77  ? -21.080 -23.709 -39.193 1.00 15.04 ? 45  ARG B CD  1 
ATOM   2067 N NE  . ARG B 1 77  ? -20.179 -24.393 -40.085 1.00 14.66 ? 45  ARG B NE  1 
ATOM   2068 C CZ  . ARG B 1 77  ? -19.806 -23.918 -41.258 1.00 14.67 ? 45  ARG B CZ  1 
ATOM   2069 N NH1 . ARG B 1 77  ? -20.219 -22.721 -41.722 1.00 14.76 ? 45  ARG B NH1 1 
ATOM   2070 N NH2 . ARG B 1 77  ? -18.974 -24.630 -41.975 1.00 15.24 ? 45  ARG B NH2 1 
ATOM   2071 N N   . LEU B 1 78  ? -18.239 -23.069 -34.503 1.00 13.20 ? 46  LEU B N   1 
ATOM   2072 C CA  . LEU B 1 78  ? -17.343 -23.255 -33.340 1.00 13.95 ? 46  LEU B CA  1 
ATOM   2073 C C   . LEU B 1 78  ? -18.145 -23.804 -32.166 1.00 14.14 ? 46  LEU B C   1 
ATOM   2074 O O   . LEU B 1 78  ? -19.333 -23.416 -32.001 1.00 13.70 ? 46  LEU B O   1 
ATOM   2075 C CB  . LEU B 1 78  ? -16.708 -21.913 -32.930 1.00 14.71 ? 46  LEU B CB  1 
ATOM   2076 C CG  . LEU B 1 78  ? -15.772 -21.239 -33.947 1.00 14.11 ? 46  LEU B CG  1 
ATOM   2077 C CD1 . LEU B 1 78  ? -14.936 -22.269 -34.654 1.00 17.04 ? 46  LEU B CD1 1 
ATOM   2078 C CD2 . LEU B 1 78  ? -16.545 -20.372 -34.925 1.00 14.12 ? 46  LEU B CD2 1 
ATOM   2079 N N   . LYS B 1 79  ? -17.484 -24.601 -31.335 1.00 14.85 ? 47  LYS B N   1 
ATOM   2080 C CA  . LYS B 1 79  ? -18.087 -24.997 -30.056 1.00 17.34 ? 47  LYS B CA  1 
ATOM   2081 C C   . LYS B 1 79  ? -17.021 -25.029 -28.972 1.00 17.13 ? 47  LYS B C   1 
ATOM   2082 O O   . LYS B 1 79  ? -15.868 -25.452 -29.232 1.00 16.57 ? 47  LYS B O   1 
ATOM   2083 C CB  . LYS B 1 79  ? -18.902 -26.273 -30.226 1.00 22.54 ? 47  LYS B CB  1 
ATOM   2084 C CG  . LYS B 1 79  ? -18.144 -27.507 -30.600 1.00 29.00 ? 47  LYS B CG  1 
ATOM   2085 C CD  . LYS B 1 79  ? -19.101 -28.689 -30.847 1.00 32.73 ? 47  LYS B CD  1 
ATOM   2086 C CE  . LYS B 1 79  ? -18.361 -29.812 -31.537 1.00 35.40 ? 47  LYS B CE  1 
ATOM   2087 N NZ  . LYS B 1 79  ? -18.776 -31.109 -30.965 1.00 41.93 ? 47  LYS B NZ  1 
ATOM   2088 N N   . VAL B 1 80  ? -17.393 -24.525 -27.794 1.00 16.49 ? 48  VAL B N   1 
ATOM   2089 C CA  . VAL B 1 80  ? -16.512 -24.618 -26.611 1.00 18.35 ? 48  VAL B CA  1 
ATOM   2090 C C   . VAL B 1 80  ? -16.578 -26.068 -26.120 1.00 18.66 ? 48  VAL B C   1 
ATOM   2091 O O   . VAL B 1 80  ? -17.674 -26.520 -25.743 1.00 18.73 ? 48  VAL B O   1 
ATOM   2092 C CB  . VAL B 1 80  ? -16.941 -23.581 -25.565 1.00 19.58 ? 48  VAL B CB  1 
ATOM   2093 C CG1 . VAL B 1 80  ? -16.060 -23.671 -24.335 1.00 17.25 ? 48  VAL B CG1 1 
ATOM   2094 C CG2 . VAL B 1 80  ? -16.910 -22.178 -26.138 1.00 20.41 ? 48  VAL B CG2 1 
ATOM   2095 N N   . THR B 1 81  ? -15.480 -26.795 -26.129 1.00 19.94 ? 49  THR B N   1 
ATOM   2096 C CA  . THR B 1 81  ? -15.443 -28.238 -25.739 1.00 21.10 ? 49  THR B CA  1 
ATOM   2097 C C   . THR B 1 81  ? -14.921 -28.419 -24.292 1.00 24.06 ? 49  THR B C   1 
ATOM   2098 O O   . THR B 1 81  ? -15.160 -29.527 -23.767 1.00 27.93 ? 49  THR B O   1 
ATOM   2099 C CB  . THR B 1 81  ? -14.615 -29.015 -26.753 1.00 19.07 ? 49  THR B CB  1 
ATOM   2100 O OG1 . THR B 1 81  ? -13.394 -28.292 -26.854 1.00 19.48 ? 49  THR B OG1 1 
ATOM   2101 C CG2 . THR B 1 81  ? -15.295 -29.119 -28.105 1.00 22.81 ? 49  THR B CG2 1 
ATOM   2102 N N   . LYS B 1 82  ? -14.234 -27.419 -23.694 1.00 21.49 ? 50  LYS B N   1 
ATOM   2103 C CA  . LYS B 1 82  ? -13.754 -27.432 -22.285 1.00 21.72 ? 50  LYS B CA  1 
ATOM   2104 C C   . LYS B 1 82  ? -13.829 -26.014 -21.732 1.00 23.06 ? 50  LYS B C   1 
ATOM   2105 O O   . LYS B 1 82  ? -13.540 -25.023 -22.465 1.00 19.90 ? 50  LYS B O   1 
ATOM   2106 C CB  . LYS B 1 82  ? -12.337 -28.020 -22.174 1.00 22.10 ? 50  LYS B CB  1 
ATOM   2107 N N   . GLY B 1 83  ? -14.220 -25.901 -20.465 1.00 24.77 ? 51  GLY B N   1 
ATOM   2108 C CA  . GLY B 1 83  ? -14.242 -24.626 -19.719 1.00 23.04 ? 51  GLY B CA  1 
ATOM   2109 C C   . GLY B 1 83  ? -15.426 -23.748 -20.070 1.00 23.17 ? 51  GLY B C   1 
ATOM   2110 O O   . GLY B 1 83  ? -15.371 -22.549 -19.765 1.00 28.79 ? 51  GLY B O   1 
ATOM   2111 N N   . GLY B 1 84  ? -16.464 -24.280 -20.723 1.00 24.38 ? 52  GLY B N   1 
ATOM   2112 C CA  . GLY B 1 84  ? -17.644 -23.473 -21.075 1.00 24.95 ? 52  GLY B CA  1 
ATOM   2113 C C   . GLY B 1 84  ? -18.593 -23.461 -19.886 1.00 23.33 ? 52  GLY B C   1 
ATOM   2114 O O   . GLY B 1 84  ? -18.617 -24.422 -19.126 1.00 25.72 ? 52  GLY B O   1 
ATOM   2115 N N   . PRO B 1 85  ? -19.345 -22.375 -19.634 1.00 25.27 ? 53  PRO B N   1 
ATOM   2116 C CA  . PRO B 1 85  ? -19.366 -21.204 -20.507 1.00 22.66 ? 53  PRO B CA  1 
ATOM   2117 C C   . PRO B 1 85  ? -18.177 -20.300 -20.178 1.00 21.85 ? 53  PRO B C   1 
ATOM   2118 O O   . PRO B 1 85  ? -17.733 -20.246 -19.021 1.00 19.44 ? 53  PRO B O   1 
ATOM   2119 C CB  . PRO B 1 85  ? -20.742 -20.592 -20.195 1.00 23.96 ? 53  PRO B CB  1 
ATOM   2120 C CG  . PRO B 1 85  ? -20.862 -20.869 -18.699 1.00 24.62 ? 53  PRO B CG  1 
ATOM   2121 C CD  . PRO B 1 85  ? -20.300 -22.259 -18.515 1.00 23.86 ? 53  PRO B CD  1 
ATOM   2122 N N   . LEU B 1 86  ? -17.672 -19.582 -21.168 1.00 19.29 ? 54  LEU B N   1 
ATOM   2123 C CA  . LEU B 1 86  ? -16.519 -18.683 -20.943 1.00 19.50 ? 54  LEU B CA  1 
ATOM   2124 C C   . LEU B 1 86  ? -17.027 -17.482 -20.158 1.00 19.88 ? 54  LEU B C   1 
ATOM   2125 O O   . LEU B 1 86  ? -18.124 -17.008 -20.412 1.00 20.24 ? 54  LEU B O   1 
ATOM   2126 C CB  . LEU B 1 86  ? -15.928 -18.241 -22.276 1.00 19.72 ? 54  LEU B CB  1 
ATOM   2127 C CG  . LEU B 1 86  ? -15.560 -19.374 -23.225 1.00 21.20 ? 54  LEU B CG  1 
ATOM   2128 C CD1 . LEU B 1 86  ? -15.246 -18.813 -24.602 1.00 22.04 ? 54  LEU B CD1 1 
ATOM   2129 C CD2 . LEU B 1 86  ? -14.405 -20.195 -22.687 1.00 21.64 ? 54  LEU B CD2 1 
ATOM   2130 N N   . PRO B 1 87  ? -16.250 -16.980 -19.172 1.00 17.57 ? 55  PRO B N   1 
ATOM   2131 C CA  . PRO B 1 87  ? -16.591 -15.761 -18.433 1.00 18.65 ? 55  PRO B CA  1 
ATOM   2132 C C   . PRO B 1 87  ? -16.109 -14.449 -19.070 1.00 21.29 ? 55  PRO B C   1 
ATOM   2133 O O   . PRO B 1 87  ? -16.040 -13.449 -18.370 1.00 24.24 ? 55  PRO B O   1 
ATOM   2134 C CB  . PRO B 1 87  ? -15.852 -15.953 -17.091 1.00 18.33 ? 55  PRO B CB  1 
ATOM   2135 C CG  . PRO B 1 87  ? -14.649 -16.782 -17.460 1.00 20.67 ? 55  PRO B CG  1 
ATOM   2136 C CD  . PRO B 1 87  ? -15.073 -17.665 -18.619 1.00 19.59 ? 55  PRO B CD  1 
ATOM   2137 N N   . PHE B 1 88  ? -15.789 -14.489 -20.372 1.00 19.65 ? 56  PHE B N   1 
ATOM   2138 C CA  . PHE B 1 88  ? -15.293 -13.312 -21.124 1.00 17.85 ? 56  PHE B CA  1 
ATOM   2139 C C   . PHE B 1 88  ? -15.910 -13.308 -22.518 1.00 16.46 ? 56  PHE B C   1 
ATOM   2140 O O   . PHE B 1 88  ? -16.435 -14.357 -23.008 1.00 15.49 ? 56  PHE B O   1 
ATOM   2141 C CB  . PHE B 1 88  ? -13.759 -13.312 -21.179 1.00 16.22 ? 56  PHE B CB  1 
ATOM   2142 C CG  . PHE B 1 88  ? -13.155 -14.567 -21.766 1.00 17.53 ? 56  PHE B CG  1 
ATOM   2143 C CD1 . PHE B 1 88  ? -12.946 -14.684 -23.147 1.00 16.52 ? 56  PHE B CD1 1 
ATOM   2144 C CD2 . PHE B 1 88  ? -12.811 -15.659 -20.978 1.00 16.30 ? 56  PHE B CD2 1 
ATOM   2145 C CE1 . PHE B 1 88  ? -12.385 -15.846 -23.679 1.00 15.74 ? 56  PHE B CE1 1 
ATOM   2146 C CE2 . PHE B 1 88  ? -12.276 -16.827 -21.522 1.00 17.37 ? 56  PHE B CE2 1 
ATOM   2147 C CZ  . PHE B 1 88  ? -12.104 -16.929 -22.893 1.00 15.74 ? 56  PHE B CZ  1 
ATOM   2148 N N   . ALA B 1 89  ? -15.757 -12.161 -23.181 1.00 16.84 ? 57  ALA B N   1 
ATOM   2149 C CA  . ALA B 1 89  ? -16.345 -11.867 -24.490 1.00 13.81 ? 57  ALA B CA  1 
ATOM   2150 C C   . ALA B 1 89  ? -15.764 -12.831 -25.507 1.00 15.36 ? 57  ALA B C   1 
ATOM   2151 O O   . ALA B 1 89  ? -14.553 -12.806 -25.696 1.00 14.06 ? 57  ALA B O   1 
ATOM   2152 C CB  . ALA B 1 89  ? -16.073 -10.449 -24.885 1.00 13.52 ? 57  ALA B CB  1 
ATOM   2153 N N   . TRP B 1 90  ? -16.642 -13.569 -26.175 1.00 13.29 ? 58  TRP B N   1 
ATOM   2154 C CA  . TRP B 1 90  ? -16.279 -14.302 -27.392 1.00 13.92 ? 58  TRP B CA  1 
ATOM   2155 C C   . TRP B 1 90  ? -15.452 -13.430 -28.363 1.00 14.71 ? 58  TRP B C   1 
ATOM   2156 O O   . TRP B 1 90  ? -14.551 -13.979 -29.049 1.00 15.42 ? 58  TRP B O   1 
ATOM   2157 C CB  . TRP B 1 90  ? -17.549 -14.765 -28.089 1.00 14.92 ? 58  TRP B CB  1 
ATOM   2158 C CG  . TRP B 1 90  ? -17.203 -15.525 -29.333 1.00 15.52 ? 58  TRP B CG  1 
ATOM   2159 C CD1 . TRP B 1 90  ? -17.142 -15.043 -30.614 1.00 16.54 ? 58  TRP B CD1 1 
ATOM   2160 C CD2 . TRP B 1 90  ? -16.780 -16.891 -29.393 1.00 15.51 ? 58  TRP B CD2 1 
ATOM   2161 N NE1 . TRP B 1 90  ? -16.736 -16.027 -31.472 1.00 16.15 ? 58  TRP B NE1 1 
ATOM   2162 C CE2 . TRP B 1 90  ? -16.526 -17.173 -30.758 1.00 15.96 ? 58  TRP B CE2 1 
ATOM   2163 C CE3 . TRP B 1 90  ? -16.669 -17.905 -28.444 1.00 18.54 ? 58  TRP B CE3 1 
ATOM   2164 C CZ2 . TRP B 1 90  ? -16.133 -18.434 -31.175 1.00 16.90 ? 58  TRP B CZ2 1 
ATOM   2165 C CZ3 . TRP B 1 90  ? -16.303 -19.162 -28.858 1.00 17.28 ? 58  TRP B CZ3 1 
ATOM   2166 C CH2 . TRP B 1 90  ? -16.023 -19.402 -30.204 1.00 17.57 ? 58  TRP B CH2 1 
ATOM   2167 N N   . ASP B 1 91  ? -15.773 -12.128 -28.497 1.00 15.64 ? 59  ASP B N   1 
ATOM   2168 C CA  . ASP B 1 91  ? -15.147 -11.246 -29.505 1.00 14.21 ? 59  ASP B CA  1 
ATOM   2169 C C   . ASP B 1 91  ? -13.611 -11.267 -29.377 1.00 13.91 ? 59  ASP B C   1 
ATOM   2170 O O   . ASP B 1 91  ? -12.957 -10.958 -30.399 1.00 15.81 ? 59  ASP B O   1 
ATOM   2171 C CB  . ASP B 1 91  ? -15.685 -9.823  -29.422 1.00 12.86 ? 59  ASP B CB  1 
ATOM   2172 C CG  . ASP B 1 91  ? -17.122 -9.655  -29.844 1.00 14.61 ? 59  ASP B CG  1 
ATOM   2173 O OD1 . ASP B 1 91  ? -17.547 -10.479 -30.742 1.00 14.90 ? 59  ASP B OD1 1 
ATOM   2174 O OD2 . ASP B 1 91  ? -17.814 -8.702  -29.293 1.00 15.21 ? 59  ASP B OD2 1 
ATOM   2175 N N   . ILE B 1 92  ? -13.025 -11.490 -28.201 1.00 14.50 ? 60  ILE B N   1 
ATOM   2176 C CA  . ILE B 1 92  ? -11.524 -11.475 -28.159 1.00 13.37 ? 60  ILE B CA  1 
ATOM   2177 C C   . ILE B 1 92  ? -10.969 -12.729 -28.831 1.00 14.35 ? 60  ILE B C   1 
ATOM   2178 O O   . ILE B 1 92  ? -9.741  -12.703 -29.248 1.00 14.65 ? 60  ILE B O   1 
ATOM   2179 C CB  . ILE B 1 92  ? -10.941 -11.233 -26.753 1.00 14.00 ? 60  ILE B CB  1 
ATOM   2180 C CG1 . ILE B 1 92  ? -11.208 -12.370 -25.778 1.00 15.65 ? 60  ILE B CG1 1 
ATOM   2181 C CG2 . ILE B 1 92  ? -11.437 -9.889  -26.258 1.00 14.63 ? 60  ILE B CG2 1 
ATOM   2182 C CD1 . ILE B 1 92  ? -10.322 -12.316 -24.561 1.00 16.11 ? 60  ILE B CD1 1 
ATOM   2183 N N   . LEU B 1 93  ? -11.761 -13.789 -28.948 1.00 13.34 ? 61  LEU B N   1 
ATOM   2184 C CA  . LEU B 1 93  ? -11.301 -15.043 -29.595 1.00 13.15 ? 61  LEU B CA  1 
ATOM   2185 C C   . LEU B 1 93  ? -11.557 -15.043 -31.096 1.00 13.21 ? 61  LEU B C   1 
ATOM   2186 O O   . LEU B 1 93  ? -10.849 -15.738 -31.818 1.00 12.80 ? 61  LEU B O   1 
ATOM   2187 C CB  . LEU B 1 93  ? -12.001 -16.226 -28.952 1.00 12.63 ? 61  LEU B CB  1 
ATOM   2188 C CG  . LEU B 1 93  ? -11.776 -16.365 -27.445 1.00 12.89 ? 61  LEU B CG  1 
ATOM   2189 C CD1 . LEU B 1 93  ? -12.330 -17.700 -26.989 1.00 15.59 ? 61  LEU B CD1 1 
ATOM   2190 C CD2 . LEU B 1 93  ? -10.292 -16.264 -27.103 1.00 15.62 ? 61  LEU B CD2 1 
ATOM   2191 N N   . SER B 1 94  ? -12.530 -14.289 -31.567 1.00 12.35 ? 62  SER B N   1 
ATOM   2192 C CA  . SER B 1 94  ? -13.008 -14.476 -32.959 1.00 12.65 ? 62  SER B CA  1 
ATOM   2193 C C   . SER B 1 94  ? -11.901 -14.153 -33.975 1.00 12.69 ? 62  SER B C   1 
ATOM   2194 O O   . SER B 1 94  ? -11.861 -14.811 -35.040 1.00 12.72 ? 62  SER B O   1 
ATOM   2195 C CB  . SER B 1 94  ? -14.272 -13.728 -33.207 1.00 12.59 ? 62  SER B CB  1 
ATOM   2196 O OG  . SER B 1 94  ? -14.129 -12.333 -33.013 1.00 13.96 ? 62  SER B OG  1 
ATOM   2197 N N   . PRO B 1 95  ? -11.042 -13.098 -33.811 1.00 12.23 ? 63  PRO B N   1 
ATOM   2198 C CA  . PRO B 1 95  ? -9.946  -12.874 -34.754 1.00 11.37 ? 63  PRO B CA  1 
ATOM   2199 C C   . PRO B 1 95  ? -8.852  -13.943 -34.697 1.00 13.06 ? 63  PRO B C   1 
ATOM   2200 O O   . PRO B 1 95  ? -8.032  -13.987 -35.625 1.00 13.92 ? 63  PRO B O   1 
ATOM   2201 C CB  . PRO B 1 95  ? -9.382  -11.503 -34.381 1.00 12.48 ? 63  PRO B CB  1 
ATOM   2202 C CG  . PRO B 1 95  ? -10.487 -10.869 -33.565 1.00 11.71 ? 63  PRO B CG  1 
ATOM   2203 C CD  . PRO B 1 95  ? -11.033 -12.053 -32.778 1.00 11.68 ? 63  PRO B CD  1 
ATOM   2204 N N   . GLN B 1 96  ? -8.810  -14.798 -33.661 1.00 13.43 ? 64  GLN B N   1 
ATOM   2205 C CA  . GLN B 1 96  ? -7.799  -15.883 -33.564 1.00 13.30 ? 64  GLN B CA  1 
ATOM   2206 C C   . GLN B 1 96  ? -8.330  -17.109 -34.301 1.00 15.03 ? 64  GLN B C   1 
ATOM   2207 O O   . GLN B 1 96  ? -7.554  -17.873 -34.826 1.00 14.89 ? 64  GLN B O   1 
ATOM   2208 C CB  . GLN B 1 96  ? -7.354  -16.209 -32.155 1.00 14.23 ? 64  GLN B CB  1 
ATOM   2209 C CG  . GLN B 1 96  ? -7.438  -15.059 -31.170 1.00 13.43 ? 64  GLN B CG  1 
ATOM   2210 C CD  . GLN B 1 96  ? -6.877  -13.740 -31.639 1.00 13.78 ? 64  GLN B CD  1 
ATOM   2211 O OE1 . GLN B 1 96  ? -6.034  -13.660 -32.557 1.00 15.51 ? 64  GLN B OE1 1 
ATOM   2212 N NE2 . GLN B 1 96  ? -7.421  -12.683 -31.062 1.00 13.82 ? 64  GLN B NE2 1 
ATOM   2213 N N   . ILE B 1 97  ? -9.633  -17.195 -34.492 1.00 16.76 ? 65  ILE B N   1 
ATOM   2214 C CA  . ILE B 1 97  ? -10.257 -18.338 -35.210 1.00 16.74 ? 65  ILE B CA  1 
ATOM   2215 C C   . ILE B 1 97  ? -10.064 -18.146 -36.709 1.00 17.81 ? 65  ILE B C   1 
ATOM   2216 O O   . ILE B 1 97  ? -9.797  -19.048 -37.532 1.00 21.60 ? 65  ILE B O   1 
ATOM   2217 C CB  . ILE B 1 97  ? -11.726 -18.434 -34.768 1.00 18.14 ? 65  ILE B CB  1 
ATOM   2218 C CG1 . ILE B 1 97  ? -11.775 -18.755 -33.281 1.00 21.77 ? 65  ILE B CG1 1 
ATOM   2219 C CG2 . ILE B 1 97  ? -12.460 -19.439 -35.628 1.00 20.04 ? 65  ILE B CG2 1 
ATOM   2220 C CD1 . ILE B 1 97  ? -13.123 -18.679 -32.681 1.00 26.55 ? 65  ILE B CD1 1 
HETATM 2221 N N1  . CH6 B 1 101 ? -10.066 -16.852 -36.889 1.00 19.64 ? 68  CH6 B N1  1 
HETATM 2222 C CE  . CH6 B 1 101 ? -14.500 -18.212 -39.786 1.00 16.23 ? 68  CH6 B CE  1 
HETATM 2223 S SD  . CH6 B 1 101 ? -13.898 -16.575 -39.690 1.00 16.12 ? 68  CH6 B SD  1 
HETATM 2224 C CG1 . CH6 B 1 101 ? -12.172 -16.887 -39.463 1.00 18.60 ? 68  CH6 B CG1 1 
HETATM 2225 C CB1 . CH6 B 1 101 ? -11.509 -15.923 -38.554 1.00 18.15 ? 68  CH6 B CB1 1 
HETATM 2226 C CA1 . CH6 B 1 101 ? -10.063 -16.299 -38.202 1.00 17.36 ? 68  CH6 B CA1 1 
HETATM 2227 C C1  . CH6 B 1 101 ? -9.204  -15.085 -38.302 1.00 16.10 ? 68  CH6 B C1  1 
HETATM 2228 N N2  . CH6 B 1 101 ? -9.627  -13.721 -38.466 1.00 13.29 ? 68  CH6 B N2  1 
HETATM 2229 O OH  . CH6 B 1 101 ? -11.452 -7.006  -37.851 1.00 17.61 ? 68  CH6 B OH  1 
HETATM 2230 C CD2 . CH6 B 1 101 ? -8.540  -9.222  -38.357 1.00 18.88 ? 68  CH6 B CD2 1 
HETATM 2231 C CE2 . CH6 B 1 101 ? -9.298  -8.062  -38.186 1.00 18.13 ? 68  CH6 B CE2 1 
HETATM 2232 C CZ  . CH6 B 1 101 ? -10.713 -8.168  -37.992 1.00 18.60 ? 68  CH6 B CZ  1 
HETATM 2233 C CE1 . CH6 B 1 101 ? -11.291 -9.405  -37.914 1.00 17.64 ? 68  CH6 B CE1 1 
HETATM 2234 C CD1 . CH6 B 1 101 ? -10.510 -10.564 -38.095 1.00 17.51 ? 68  CH6 B CD1 1 
HETATM 2235 C CG2 . CH6 B 1 101 ? -9.114  -10.473 -38.286 1.00 17.88 ? 68  CH6 B CG2 1 
HETATM 2236 C CB2 . CH6 B 1 101 ? -8.162  -11.581 -38.514 1.00 15.39 ? 68  CH6 B CB2 1 
HETATM 2237 C CA2 . CH6 B 1 101 ? -8.440  -13.053 -38.499 1.00 15.12 ? 68  CH6 B CA2 1 
HETATM 2238 C C2  . CH6 B 1 101 ? -7.382  -13.943 -38.296 1.00 13.52 ? 68  CH6 B C2  1 
HETATM 2239 O O2  . CH6 B 1 101 ? -6.093  -13.663 -38.287 1.00 16.52 ? 68  CH6 B O2  1 
HETATM 2240 N N3  . CH6 B 1 101 ? -7.819  -15.170 -38.256 1.00 13.99 ? 68  CH6 B N3  1 
HETATM 2241 C CA3 . CH6 B 1 101 ? -6.956  -16.298 -37.963 1.00 14.29 ? 68  CH6 B CA3 1 
HETATM 2242 C C3  . CH6 B 1 101 ? -7.008  -17.457 -38.953 1.00 12.27 ? 68  CH6 B C3  1 
HETATM 2243 O O3  . CH6 B 1 101 ? -6.361  -18.460 -38.676 1.00 15.35 ? 68  CH6 B O3  1 
ATOM   2244 N N   . SER B 1 102 ? -7.355  -17.011 -40.378 1.00 12.77 ? 69  SER B N   1 
ATOM   2245 C CA  . SER B 1 102 ? -7.538  -17.994 -41.393 1.00 12.68 ? 69  SER B CA  1 
ATOM   2246 C C   . SER B 1 102 ? -7.146  -17.326 -42.717 1.00 14.23 ? 69  SER B C   1 
ATOM   2247 O O   . SER B 1 102 ? -7.988  -17.149 -43.621 1.00 14.72 ? 69  SER B O   1 
ATOM   2248 C CB  . SER B 1 102 ? -8.956  -18.558 -41.286 1.00 12.62 ? 69  SER B CB  1 
ATOM   2249 O OG  . SER B 1 102 ? -9.205  -19.471 -42.308 1.00 12.00 ? 69  SER B OG  1 
ATOM   2250 N N   . LYS B 1 103 ? -5.891  -16.862 -42.792 1.00 15.80 ? 70  LYS B N   1 
ATOM   2251 C CA  . LYS B 1 103 ? -5.451  -15.858 -43.796 1.00 15.92 ? 70  LYS B CA  1 
ATOM   2252 C C   . LYS B 1 103 ? -5.142  -16.504 -45.133 1.00 14.09 ? 70  LYS B C   1 
ATOM   2253 O O   . LYS B 1 103 ? -4.861  -15.777 -46.075 1.00 14.36 ? 70  LYS B O   1 
ATOM   2254 C CB  . LYS B 1 103 ? -4.233  -15.060 -43.321 1.00 19.03 ? 70  LYS B CB  1 
ATOM   2255 C CG  . LYS B 1 103 ? -4.512  -14.047 -42.213 1.00 22.44 ? 70  LYS B CG  1 
ATOM   2256 C CD  . LYS B 1 103 ? -5.514  -13.009 -42.579 1.00 26.40 ? 70  LYS B CD  1 
ATOM   2257 C CE  . LYS B 1 103 ? -5.648  -11.895 -41.560 1.00 31.68 ? 70  LYS B CE  1 
ATOM   2258 N NZ  . LYS B 1 103 ? -4.714  -10.808 -41.874 1.00 31.95 ? 70  LYS B NZ  1 
ATOM   2259 N N   . ALA B 1 104 ? -5.284  -17.820 -45.280 1.00 13.92 ? 71  ALA B N   1 
ATOM   2260 C CA  . ALA B 1 104 ? -5.407  -18.426 -46.625 1.00 13.96 ? 71  ALA B CA  1 
ATOM   2261 C C   . ALA B 1 104 ? -6.644  -17.964 -47.402 1.00 13.90 ? 71  ALA B C   1 
ATOM   2262 O O   . ALA B 1 104 ? -6.619  -18.020 -48.645 1.00 11.05 ? 71  ALA B O   1 
ATOM   2263 C CB  . ALA B 1 104 ? -5.421  -19.930 -46.482 1.00 16.22 ? 71  ALA B CB  1 
ATOM   2264 N N   . TYR B 1 105 ? -7.631  -17.363 -46.735 1.00 11.83 ? 72  TYR B N   1 
ATOM   2265 C CA  . TYR B 1 105 ? -8.884  -16.919 -47.380 1.00 12.20 ? 72  TYR B CA  1 
ATOM   2266 C C   . TYR B 1 105 ? -8.893  -15.396 -47.453 1.00 13.09 ? 72  TYR B C   1 
ATOM   2267 O O   . TYR B 1 105 ? -9.695  -14.746 -46.746 1.00 13.85 ? 72  TYR B O   1 
ATOM   2268 C CB  . TYR B 1 105 ? -10.136 -17.430 -46.658 1.00 12.59 ? 72  TYR B CB  1 
ATOM   2269 C CG  . TYR B 1 105 ? -10.284 -18.921 -46.488 1.00 11.68 ? 72  TYR B CG  1 
ATOM   2270 C CD1 . TYR B 1 105 ? -9.632  -19.604 -45.486 1.00 12.07 ? 72  TYR B CD1 1 
ATOM   2271 C CD2 . TYR B 1 105 ? -11.207 -19.642 -47.234 1.00 11.47 ? 72  TYR B CD2 1 
ATOM   2272 C CE1 . TYR B 1 105 ? -9.817  -20.979 -45.321 1.00 11.52 ? 72  TYR B CE1 1 
ATOM   2273 C CE2 . TYR B 1 105 ? -11.415 -21.003 -47.077 1.00 11.13 ? 72  TYR B CE2 1 
ATOM   2274 C CZ  . TYR B 1 105 ? -10.730 -21.674 -46.101 1.00 11.95 ? 72  TYR B CZ  1 
ATOM   2275 O OH  . TYR B 1 105 ? -10.926 -23.032 -45.942 1.00 13.15 ? 72  TYR B OH  1 
ATOM   2276 N N   . VAL B 1 106 ? -7.952  -14.865 -48.252 1.00 13.12 ? 73  VAL B N   1 
ATOM   2277 C CA  . VAL B 1 106 ? -7.841  -13.417 -48.570 1.00 12.38 ? 73  VAL B CA  1 
ATOM   2278 C C   . VAL B 1 106 ? -7.693  -13.300 -50.066 1.00 13.21 ? 73  VAL B C   1 
ATOM   2279 O O   . VAL B 1 106 ? -6.720  -13.874 -50.620 1.00 14.57 ? 73  VAL B O   1 
ATOM   2280 C CB  . VAL B 1 106 ? -6.661  -12.728 -47.880 1.00 12.63 ? 73  VAL B CB  1 
ATOM   2281 C CG1 . VAL B 1 106 ? -6.596  -11.233 -48.194 1.00 13.49 ? 73  VAL B CG1 1 
ATOM   2282 C CG2 . VAL B 1 106 ? -6.674  -12.934 -46.388 1.00 12.39 ? 73  VAL B CG2 1 
ATOM   2283 N N   . LYS B 1 107 ? -8.612  -12.560 -50.670 1.00 13.47 ? 74  LYS B N   1 
ATOM   2284 C CA  . LYS B 1 107 ? -8.541  -12.309 -52.108 1.00 13.25 ? 74  LYS B CA  1 
ATOM   2285 C C   . LYS B 1 107 ? -7.333  -11.443 -52.367 1.00 15.33 ? 74  LYS B C   1 
ATOM   2286 O O   . LYS B 1 107 ? -7.252  -10.335 -51.746 1.00 13.73 ? 74  LYS B O   1 
ATOM   2287 C CB  . LYS B 1 107 ? -9.851  -11.732 -52.613 1.00 15.66 ? 74  LYS B CB  1 
ATOM   2288 C CG  . LYS B 1 107 ? -9.826  -11.327 -54.073 1.00 17.16 ? 74  LYS B CG  1 
ATOM   2289 C CD  . LYS B 1 107 ? -11.207 -10.840 -54.523 1.00 20.11 ? 74  LYS B CD  1 
ATOM   2290 C CE  . LYS B 1 107 ? -11.229 -10.322 -55.943 1.00 23.63 ? 74  LYS B CE  1 
ATOM   2291 N NZ  . LYS B 1 107 ? -12.644 -10.137 -56.349 1.00 25.30 ? 74  LYS B NZ  1 
ATOM   2292 N N   . HIS B 1 108 ? -6.453  -11.890 -53.271 1.00 13.58 ? 75  HIS B N   1 
ATOM   2293 C CA  . HIS B 1 108 ? -5.251  -11.095 -53.640 1.00 14.31 ? 75  HIS B CA  1 
ATOM   2294 C C   . HIS B 1 108 ? -5.304  -10.782 -55.113 1.00 15.18 ? 75  HIS B C   1 
ATOM   2295 O O   . HIS B 1 108 ? -5.479  -11.660 -55.931 1.00 13.21 ? 75  HIS B O   1 
ATOM   2296 C CB  . HIS B 1 108 ? -3.940  -11.823 -53.302 1.00 13.83 ? 75  HIS B CB  1 
ATOM   2297 C CG  . HIS B 1 108 ? -3.568  -11.692 -51.837 1.00 12.53 ? 75  HIS B CG  1 
ATOM   2298 N ND1 . HIS B 1 108 ? -4.207  -12.432 -50.815 1.00 12.68 ? 75  HIS B ND1 1 
ATOM   2299 C CD2 . HIS B 1 108 ? -2.574  -11.006 -51.237 1.00 13.77 ? 75  HIS B CD2 1 
ATOM   2300 C CE1 . HIS B 1 108 ? -3.612  -12.157 -49.664 1.00 12.00 ? 75  HIS B CE1 1 
ATOM   2301 N NE2 . HIS B 1 108 ? -2.666  -11.213 -49.882 1.00 12.90 ? 75  HIS B NE2 1 
ATOM   2302 N N   . PRO B 1 109 ? -5.024  -9.536  -55.493 1.00 15.19 ? 76  PRO B N   1 
ATOM   2303 C CA  . PRO B 1 109 ? -4.791  -9.279  -56.908 1.00 15.88 ? 76  PRO B CA  1 
ATOM   2304 C C   . PRO B 1 109 ? -3.582  -10.095 -57.389 1.00 17.56 ? 76  PRO B C   1 
ATOM   2305 O O   . PRO B 1 109 ? -2.703  -10.401 -56.601 1.00 14.66 ? 76  PRO B O   1 
ATOM   2306 C CB  . PRO B 1 109 ? -4.477  -7.784  -56.985 1.00 15.98 ? 76  PRO B CB  1 
ATOM   2307 C CG  . PRO B 1 109 ? -4.371  -7.286  -55.583 1.00 17.72 ? 76  PRO B CG  1 
ATOM   2308 C CD  . PRO B 1 109 ? -4.765  -8.380  -54.605 1.00 15.62 ? 76  PRO B CD  1 
ATOM   2309 N N   . ALA B 1 110 ? -3.490  -10.341 -58.693 1.00 18.97 ? 77  ALA B N   1 
ATOM   2310 C CA  . ALA B 1 110 ? -2.408  -11.165 -59.289 1.00 18.86 ? 77  ALA B CA  1 
ATOM   2311 C C   . ALA B 1 110 ? -1.021  -10.561 -59.008 1.00 18.15 ? 77  ALA B C   1 
ATOM   2312 O O   . ALA B 1 110 ? -0.035  -11.305 -59.006 1.00 21.60 ? 77  ALA B O   1 
ATOM   2313 C CB  . ALA B 1 110 ? -2.612  -11.351 -60.767 1.00 20.24 ? 77  ALA B CB  1 
ATOM   2314 N N   . ASP B 1 111 ? -0.925  -9.256  -58.841 1.00 16.96 ? 78  ASP B N   1 
ATOM   2315 C CA  . ASP B 1 111 ? 0.380   -8.549  -58.772 1.00 21.06 ? 78  ASP B CA  1 
ATOM   2316 C C   . ASP B 1 111 ? 0.828   -8.404  -57.307 1.00 18.27 ? 78  ASP B C   1 
ATOM   2317 O O   . ASP B 1 111 ? 1.859   -7.800  -57.104 1.00 17.59 ? 78  ASP B O   1 
ATOM   2318 C CB  . ASP B 1 111 ? 0.306   -7.207  -59.508 1.00 19.75 ? 78  ASP B CB  1 
ATOM   2319 C CG  . ASP B 1 111 ? -0.618  -6.167  -58.905 1.00 23.43 ? 78  ASP B CG  1 
ATOM   2320 O OD1 . ASP B 1 111 ? -1.546  -6.511  -58.192 1.00 25.09 ? 78  ASP B OD1 1 
ATOM   2321 O OD2 . ASP B 1 111 ? -0.442  -4.997  -59.222 1.00 29.02 ? 78  ASP B OD2 1 
ATOM   2322 N N   . ILE B 1 112 ? 0.103   -8.952  -56.324 1.00 14.21 ? 79  ILE B N   1 
ATOM   2323 C CA  . ILE B 1 112 ? 0.589   -8.996  -54.905 1.00 13.63 ? 79  ILE B CA  1 
ATOM   2324 C C   . ILE B 1 112 ? 0.811   -10.462 -54.611 1.00 12.88 ? 79  ILE B C   1 
ATOM   2325 O O   . ILE B 1 112 ? -0.153  -11.223 -54.585 1.00 14.28 ? 79  ILE B O   1 
ATOM   2326 C CB  . ILE B 1 112 ? -0.367  -8.342  -53.893 1.00 14.74 ? 79  ILE B CB  1 
ATOM   2327 C CG1 . ILE B 1 112 ? -0.647  -6.896  -54.307 1.00 15.65 ? 79  ILE B CG1 1 
ATOM   2328 C CG2 . ILE B 1 112 ? 0.200   -8.437  -52.470 1.00 15.16 ? 79  ILE B CG2 1 
ATOM   2329 C CD1 . ILE B 1 112 ? -1.547  -6.110  -53.417 1.00 16.27 ? 79  ILE B CD1 1 
ATOM   2330 N N   . PRO B 1 113 ? 2.074   -10.912 -54.431 1.00 13.32 ? 80  PRO B N   1 
ATOM   2331 C CA  . PRO B 1 113 ? 2.312   -12.297 -54.067 1.00 13.22 ? 80  PRO B CA  1 
ATOM   2332 C C   . PRO B 1 113 ? 1.469   -12.748 -52.873 1.00 12.70 ? 80  PRO B C   1 
ATOM   2333 O O   . PRO B 1 113 ? 1.476   -12.088 -51.850 1.00 12.11 ? 80  PRO B O   1 
ATOM   2334 C CB  . PRO B 1 113 ? 3.815   -12.377 -53.784 1.00 14.51 ? 80  PRO B CB  1 
ATOM   2335 C CG  . PRO B 1 113 ? 4.376   -11.234 -54.560 1.00 16.46 ? 80  PRO B CG  1 
ATOM   2336 C CD  . PRO B 1 113 ? 3.319   -10.161 -54.590 1.00 15.28 ? 80  PRO B CD  1 
ATOM   2337 N N   . ASP B 1 114 ? 0.712   -13.844 -53.031 1.00 12.80 ? 81  ASP B N   1 
ATOM   2338 C CA  . ASP B 1 114 ? -0.178  -14.333 -51.946 1.00 13.71 ? 81  ASP B CA  1 
ATOM   2339 C C   . ASP B 1 114 ? 0.623   -15.295 -51.066 1.00 12.59 ? 81  ASP B C   1 
ATOM   2340 O O   . ASP B 1 114 ? 0.429   -16.547 -51.142 1.00 12.29 ? 81  ASP B O   1 
ATOM   2341 C CB  . ASP B 1 114 ? -1.438  -14.927 -52.563 1.00 13.22 ? 81  ASP B CB  1 
ATOM   2342 C CG  . ASP B 1 114 ? -2.561  -15.073 -51.557 1.00 13.34 ? 81  ASP B CG  1 
ATOM   2343 O OD1 . ASP B 1 114 ? -2.268  -15.109 -50.359 1.00 16.04 ? 81  ASP B OD1 1 
ATOM   2344 O OD2 . ASP B 1 114 ? -3.712  -15.226 -51.998 1.00 12.94 ? 81  ASP B OD2 1 
ATOM   2345 N N   . TYR B 1 115 ? 1.565   -14.717 -50.318 1.00 12.76 ? 82  TYR B N   1 
ATOM   2346 C CA  . TYR B 1 115 ? 2.582   -15.453 -49.518 1.00 11.78 ? 82  TYR B CA  1 
ATOM   2347 C C   . TYR B 1 115 ? 1.938   -16.603 -48.743 1.00 13.00 ? 82  TYR B C   1 
ATOM   2348 O O   . TYR B 1 115 ? 2.451   -17.732 -48.721 1.00 11.36 ? 82  TYR B O   1 
ATOM   2349 C CB  . TYR B 1 115 ? 3.289   -14.405 -48.665 1.00 12.44 ? 82  TYR B CB  1 
ATOM   2350 C CG  . TYR B 1 115 ? 4.326   -14.857 -47.662 1.00 10.56 ? 82  TYR B CG  1 
ATOM   2351 C CD1 . TYR B 1 115 ? 5.585   -15.323 -48.040 1.00 11.07 ? 82  TYR B CD1 1 
ATOM   2352 C CD2 . TYR B 1 115 ? 3.998   -14.898 -46.325 1.00 9.48  ? 82  TYR B CD2 1 
ATOM   2353 C CE1 . TYR B 1 115 ? 6.496   -15.759 -47.088 1.00 11.31 ? 82  TYR B CE1 1 
ATOM   2354 C CE2 . TYR B 1 115 ? 4.919   -15.256 -45.369 1.00 10.55 ? 82  TYR B CE2 1 
ATOM   2355 C CZ  . TYR B 1 115 ? 6.178   -15.696 -45.738 1.00 10.05 ? 82  TYR B CZ  1 
ATOM   2356 O OH  . TYR B 1 115 ? 7.091   -16.061 -44.780 1.00 10.71 ? 82  TYR B OH  1 
ATOM   2357 N N   . LEU B 1 116 ? 0.846   -16.351 -48.045 1.00 13.38 ? 83  LEU B N   1 
ATOM   2358 C CA  . LEU B 1 116 ? 0.278   -17.394 -47.157 1.00 13.07 ? 83  LEU B CA  1 
ATOM   2359 C C   . LEU B 1 116 ? -0.352  -18.532 -47.972 1.00 12.93 ? 83  LEU B C   1 
ATOM   2360 O O   . LEU B 1 116 ? -0.237  -19.712 -47.509 1.00 14.13 ? 83  LEU B O   1 
ATOM   2361 C CB  . LEU B 1 116 ? -0.664  -16.721 -46.171 1.00 14.89 ? 83  LEU B CB  1 
ATOM   2362 C CG  . LEU B 1 116 ? 0.002   -15.679 -45.282 1.00 14.90 ? 83  LEU B CG  1 
ATOM   2363 C CD1 . LEU B 1 116 ? -0.997  -15.127 -44.285 1.00 16.56 ? 83  LEU B CD1 1 
ATOM   2364 C CD2 . LEU B 1 116 ? 1.204   -16.263 -44.556 1.00 13.63 ? 83  LEU B CD2 1 
ATOM   2365 N N   . LYS B 1 117 ? -0.999  -18.267 -49.121 1.00 13.43 ? 84  LYS B N   1 
ATOM   2366 C CA  . LYS B 1 117 ? -1.451  -19.370 -50.037 1.00 12.34 ? 84  LYS B CA  1 
ATOM   2367 C C   . LYS B 1 117 ? -0.241  -20.130 -50.576 1.00 13.81 ? 84  LYS B C   1 
ATOM   2368 O O   . LYS B 1 117 ? -0.291  -21.418 -50.644 1.00 13.14 ? 84  LYS B O   1 
ATOM   2369 C CB  . LYS B 1 117 ? -2.255  -18.895 -51.252 1.00 12.80 ? 84  LYS B CB  1 
ATOM   2370 C CG  . LYS B 1 117 ? -3.714  -18.584 -50.972 1.00 14.26 ? 84  LYS B CG  1 
ATOM   2371 C CD  . LYS B 1 117 ? -4.552  -18.296 -52.149 1.00 14.45 ? 84  LYS B CD  1 
ATOM   2372 C CE  . LYS B 1 117 ? -5.981  -17.915 -51.792 1.00 14.17 ? 84  LYS B CE  1 
ATOM   2373 N NZ  . LYS B 1 117 ? -6.061  -16.579 -51.135 1.00 14.16 ? 84  LYS B NZ  1 
ATOM   2374 N N   . LEU B 1 118 ? 0.779   -19.387 -51.015 1.00 11.98 ? 85  LEU B N   1 
ATOM   2375 C CA  . LEU B 1 118 ? 2.013   -19.994 -51.603 1.00 12.85 ? 85  LEU B CA  1 
ATOM   2376 C C   . LEU B 1 118 ? 2.685   -20.965 -50.609 1.00 13.01 ? 85  LEU B C   1 
ATOM   2377 O O   . LEU B 1 118 ? 3.348   -21.986 -51.050 1.00 14.35 ? 85  LEU B O   1 
ATOM   2378 C CB  . LEU B 1 118 ? 2.967   -18.867 -52.005 1.00 11.01 ? 85  LEU B CB  1 
ATOM   2379 C CG  . LEU B 1 118 ? 2.524   -18.043 -53.211 1.00 12.27 ? 85  LEU B CG  1 
ATOM   2380 C CD1 . LEU B 1 118 ? 3.349   -16.752 -53.309 1.00 13.17 ? 85  LEU B CD1 1 
ATOM   2381 C CD2 . LEU B 1 118 ? 2.626   -18.849 -54.492 1.00 14.80 ? 85  LEU B CD2 1 
ATOM   2382 N N   . SER B 1 119 ? 2.538   -20.753 -49.303 1.00 13.04 ? 86  SER B N   1 
ATOM   2383 C CA  . SER B 1 119 ? 3.170   -21.583 -48.254 1.00 12.91 ? 86  SER B CA  1 
ATOM   2384 C C   . SER B 1 119 ? 2.622   -23.006 -48.225 1.00 13.57 ? 86  SER B C   1 
ATOM   2385 O O   . SER B 1 119 ? 3.308   -23.875 -47.646 1.00 13.15 ? 86  SER B O   1 
ATOM   2386 C CB  . SER B 1 119 ? 3.018   -20.941 -46.903 1.00 12.46 ? 86  SER B CB  1 
ATOM   2387 O OG  . SER B 1 119 ? 1.694   -21.051 -46.360 1.00 13.27 ? 86  SER B OG  1 
ATOM   2388 N N   . PHE B 1 120 ? 1.456   -23.251 -48.817 1.00 13.38 ? 87  PHE B N   1 
ATOM   2389 C CA  . PHE B 1 120 ? 0.789   -24.573 -48.663 1.00 13.61 ? 87  PHE B CA  1 
ATOM   2390 C C   . PHE B 1 120 ? 1.369   -25.512 -49.697 1.00 13.31 ? 87  PHE B C   1 
ATOM   2391 O O   . PHE B 1 120 ? 1.808   -25.082 -50.747 1.00 13.79 ? 87  PHE B O   1 
ATOM   2392 C CB  . PHE B 1 120 ? -0.729  -24.457 -48.739 1.00 11.96 ? 87  PHE B CB  1 
ATOM   2393 C CG  . PHE B 1 120 ? -1.261  -23.861 -47.485 1.00 12.40 ? 87  PHE B CG  1 
ATOM   2394 C CD1 . PHE B 1 120 ? -1.360  -24.618 -46.332 1.00 13.04 ? 87  PHE B CD1 1 
ATOM   2395 C CD2 . PHE B 1 120 ? -1.541  -22.504 -47.441 1.00 13.42 ? 87  PHE B CD2 1 
ATOM   2396 C CE1 . PHE B 1 120 ? -1.811  -24.041 -45.153 1.00 13.58 ? 87  PHE B CE1 1 
ATOM   2397 C CE2 . PHE B 1 120 ? -2.062  -21.943 -46.282 1.00 13.06 ? 87  PHE B CE2 1 
ATOM   2398 C CZ  . PHE B 1 120 ? -2.153  -22.701 -45.129 1.00 11.62 ? 87  PHE B CZ  1 
ATOM   2399 N N   . PRO B 1 121 ? 1.331   -26.829 -49.477 1.00 13.73 ? 88  PRO B N   1 
ATOM   2400 C CA  . PRO B 1 121 ? 0.650   -27.451 -48.354 1.00 14.83 ? 88  PRO B CA  1 
ATOM   2401 C C   . PRO B 1 121 ? 1.335   -27.356 -46.984 1.00 13.76 ? 88  PRO B C   1 
ATOM   2402 O O   . PRO B 1 121 ? 0.684   -27.567 -45.961 1.00 15.89 ? 88  PRO B O   1 
ATOM   2403 C CB  . PRO B 1 121 ? 0.572   -28.927 -48.786 1.00 15.76 ? 88  PRO B CB  1 
ATOM   2404 C CG  . PRO B 1 121 ? 1.700   -29.113 -49.765 1.00 15.47 ? 88  PRO B CG  1 
ATOM   2405 C CD  . PRO B 1 121 ? 1.849   -27.792 -50.457 1.00 17.97 ? 88  PRO B CD  1 
ATOM   2406 N N   . GLU B 1 122 ? 2.648   -27.155 -46.935 1.00 15.06 ? 89  GLU B N   1 
ATOM   2407 C CA  . GLU B 1 122 ? 3.309   -27.243 -45.621 1.00 15.41 ? 89  GLU B CA  1 
ATOM   2408 C C   . GLU B 1 122 ? 2.670   -26.219 -44.672 1.00 14.05 ? 89  GLU B C   1 
ATOM   2409 O O   . GLU B 1 122 ? 2.385   -26.586 -43.553 1.00 15.50 ? 89  GLU B O   1 
ATOM   2410 C CB  . GLU B 1 122 ? 4.815   -27.150 -45.715 1.00 17.09 ? 89  GLU B CB  1 
ATOM   2411 C CG  . GLU B 1 122 ? 5.464   -27.555 -44.406 1.00 20.58 ? 89  GLU B CG  1 
ATOM   2412 C CD  . GLU B 1 122 ? 6.990   -27.546 -44.356 1.00 21.03 ? 89  GLU B CD  1 
ATOM   2413 O OE1 . GLU B 1 122 ? 7.596   -27.164 -45.370 1.00 26.43 ? 89  GLU B OE1 1 
ATOM   2414 O OE2 . GLU B 1 122 ? 7.538   -27.905 -43.301 1.00 22.07 ? 89  GLU B OE2 1 
ATOM   2415 N N   . GLY B 1 123 ? 2.383   -25.036 -45.170 1.00 14.59 ? 90  GLY B N   1 
ATOM   2416 C CA  . GLY B 1 123 ? 1.717   -23.980 -44.396 1.00 13.72 ? 90  GLY B CA  1 
ATOM   2417 C C   . GLY B 1 123 ? 2.688   -22.975 -43.790 1.00 13.91 ? 90  GLY B C   1 
ATOM   2418 O O   . GLY B 1 123 ? 3.789   -22.675 -44.342 1.00 13.40 ? 90  GLY B O   1 
ATOM   2419 N N   . PHE B 1 124 ? 2.261   -22.380 -42.684 1.00 13.77 ? 91  PHE B N   1 
ATOM   2420 C CA  . PHE B 1 124 ? 2.813   -21.143 -42.105 1.00 13.68 ? 91  PHE B CA  1 
ATOM   2421 C C   . PHE B 1 124 ? 2.371   -21.095 -40.647 1.00 14.17 ? 91  PHE B C   1 
ATOM   2422 O O   . PHE B 1 124 ? 1.447   -21.818 -40.174 1.00 14.44 ? 91  PHE B O   1 
ATOM   2423 C CB  . PHE B 1 124 ? 2.338   -19.935 -42.883 1.00 11.86 ? 91  PHE B CB  1 
ATOM   2424 C CG  . PHE B 1 124 ? 0.874   -19.581 -42.667 1.00 11.81 ? 91  PHE B CG  1 
ATOM   2425 C CD1 . PHE B 1 124 ? -0.111  -20.076 -43.515 1.00 13.57 ? 91  PHE B CD1 1 
ATOM   2426 C CD2 . PHE B 1 124 ? 0.523   -18.608 -41.736 1.00 12.28 ? 91  PHE B CD2 1 
ATOM   2427 C CE1 . PHE B 1 124 ? -1.451  -19.716 -43.363 1.00 13.29 ? 91  PHE B CE1 1 
ATOM   2428 C CE2 . PHE B 1 124 ? -0.815  -18.224 -41.608 1.00 12.79 ? 91  PHE B CE2 1 
ATOM   2429 C CZ  . PHE B 1 124 ? -1.788  -18.761 -42.429 1.00 13.42 ? 91  PHE B CZ  1 
ATOM   2430 N N   . LYS B 1 125 ? 3.132   -20.379 -39.879 1.00 13.12 ? 92  LYS B N   1 
ATOM   2431 C CA  . LYS B 1 125 ? 2.832   -20.127 -38.468 1.00 13.81 ? 92  LYS B CA  1 
ATOM   2432 C C   . LYS B 1 125 ? 2.595   -18.639 -38.299 1.00 13.59 ? 92  LYS B C   1 
ATOM   2433 O O   . LYS B 1 125 ? 3.060   -17.816 -39.155 1.00 14.43 ? 92  LYS B O   1 
ATOM   2434 C CB  . LYS B 1 125 ? 4.017   -20.491 -37.585 1.00 16.08 ? 92  LYS B CB  1 
ATOM   2435 C CG  . LYS B 1 125 ? 4.355   -21.967 -37.514 1.00 21.78 ? 92  LYS B CG  1 
ATOM   2436 C CD  . LYS B 1 125 ? 5.549   -22.198 -36.568 1.00 25.56 ? 92  LYS B CD  1 
ATOM   2437 C CE  . LYS B 1 125 ? 6.105   -23.600 -36.610 1.00 31.70 ? 92  LYS B CE  1 
ATOM   2438 N NZ  . LYS B 1 125 ? 4.998   -24.585 -36.631 1.00 37.30 ? 92  LYS B NZ  1 
ATOM   2439 N N   . TRP B 1 126 ? 1.803   -18.284 -37.306 1.00 12.64 ? 93  TRP B N   1 
ATOM   2440 C CA  . TRP B 1 126 ? 1.664   -16.848 -36.984 1.00 12.66 ? 93  TRP B CA  1 
ATOM   2441 C C   . TRP B 1 126 ? 1.652   -16.588 -35.474 1.00 13.39 ? 93  TRP B C   1 
ATOM   2442 O O   . TRP B 1 126 ? 1.246   -17.473 -34.660 1.00 12.62 ? 93  TRP B O   1 
ATOM   2443 C CB  . TRP B 1 126 ? 0.464   -16.177 -37.665 1.00 12.96 ? 93  TRP B CB  1 
ATOM   2444 C CG  . TRP B 1 126 ? -0.908  -16.694 -37.398 1.00 13.30 ? 93  TRP B CG  1 
ATOM   2445 C CD1 . TRP B 1 126 ? -1.580  -17.672 -38.082 1.00 14.37 ? 93  TRP B CD1 1 
ATOM   2446 C CD2 . TRP B 1 126 ? -1.839  -16.211 -36.406 1.00 12.51 ? 93  TRP B CD2 1 
ATOM   2447 N NE1 . TRP B 1 126 ? -2.834  -17.856 -37.566 1.00 14.77 ? 93  TRP B NE1 1 
ATOM   2448 C CE2 . TRP B 1 126 ? -3.034  -16.960 -36.545 1.00 13.54 ? 93  TRP B CE2 1 
ATOM   2449 C CE3 . TRP B 1 126 ? -1.769  -15.276 -35.386 1.00 14.10 ? 93  TRP B CE3 1 
ATOM   2450 C CZ2 . TRP B 1 126 ? -4.143  -16.767 -35.717 1.00 14.33 ? 93  TRP B CZ2 1 
ATOM   2451 C CZ3 . TRP B 1 126 ? -2.877  -15.046 -34.584 1.00 14.40 ? 93  TRP B CZ3 1 
ATOM   2452 C CH2 . TRP B 1 126 ? -4.077  -15.753 -34.790 1.00 15.17 ? 93  TRP B CH2 1 
ATOM   2453 N N   . GLU B 1 127 ? 2.082   -15.368 -35.119 1.00 13.37 ? 94  GLU B N   1 
ATOM   2454 C CA  . GLU B 1 127 ? 2.176   -14.956 -33.705 1.00 15.32 ? 94  GLU B CA  1 
ATOM   2455 C C   . GLU B 1 127 ? 1.592   -13.548 -33.624 1.00 14.13 ? 94  GLU B C   1 
ATOM   2456 O O   . GLU B 1 127 ? 1.849   -12.734 -34.521 1.00 16.38 ? 94  GLU B O   1 
ATOM   2457 C CB  . GLU B 1 127 ? 3.574   -14.856 -33.129 1.00 16.92 ? 94  GLU B CB  1 
ATOM   2458 C CG  . GLU B 1 127 ? 4.243   -16.157 -32.879 1.00 22.35 ? 94  GLU B CG  1 
ATOM   2459 C CD  . GLU B 1 127 ? 5.529   -15.902 -32.065 1.00 24.28 ? 94  GLU B CD  1 
ATOM   2460 O OE1 . GLU B 1 127 ? 6.107   -14.696 -32.043 1.00 22.31 ? 94  GLU B OE1 1 
ATOM   2461 O OE2 . GLU B 1 127 ? 5.922   -16.878 -31.474 1.00 30.85 ? 94  GLU B OE2 1 
ATOM   2462 N N   . ARG B 1 128 ? 0.788   -13.322 -32.605 1.00 13.39 ? 95  ARG B N   1 
ATOM   2463 C CA  . ARG B 1 128 ? 0.046   -12.057 -32.503 1.00 12.92 ? 95  ARG B CA  1 
ATOM   2464 C C   . ARG B 1 128 ? 0.100   -11.540 -31.083 1.00 13.30 ? 95  ARG B C   1 
ATOM   2465 O O   . ARG B 1 128 ? 0.019   -12.322 -30.134 1.00 12.13 ? 95  ARG B O   1 
ATOM   2466 C CB  . ARG B 1 128 ? -1.391  -12.278 -32.948 1.00 14.57 ? 95  ARG B CB  1 
ATOM   2467 C CG  . ARG B 1 128 ? -2.271  -11.043 -32.782 1.00 12.87 ? 95  ARG B CG  1 
ATOM   2468 C CD  . ARG B 1 128 ? -3.644  -11.231 -33.401 1.00 12.91 ? 95  ARG B CD  1 
ATOM   2469 N NE  . ARG B 1 128 ? -3.588  -11.282 -34.867 1.00 12.92 ? 95  ARG B NE  1 
ATOM   2470 C CZ  . ARG B 1 128 ? -4.459  -11.890 -35.647 1.00 13.03 ? 95  ARG B CZ  1 
ATOM   2471 N NH1 . ARG B 1 128 ? -5.516  -12.467 -35.126 1.00 13.10 ? 95  ARG B NH1 1 
ATOM   2472 N NH2 . ARG B 1 128 ? -4.316  -11.884 -36.974 1.00 12.45 ? 95  ARG B NH2 1 
ATOM   2473 N N   . VAL B 1 129 ? 0.163   -10.227 -30.977 1.00 12.74 ? 96  VAL B N   1 
ATOM   2474 C CA  . VAL B 1 129 ? -0.171  -9.529  -29.698 1.00 14.43 ? 96  VAL B CA  1 
ATOM   2475 C C   . VAL B 1 129 ? -1.284  -8.515  -29.973 1.00 13.63 ? 96  VAL B C   1 
ATOM   2476 O O   . VAL B 1 129 ? -1.203  -7.758  -30.977 1.00 15.06 ? 96  VAL B O   1 
ATOM   2477 C CB  . VAL B 1 129 ? 1.047   -8.850  -29.053 1.00 13.89 ? 96  VAL B CB  1 
ATOM   2478 C CG1 . VAL B 1 129 ? 1.706   -7.831  -29.965 1.00 13.28 ? 96  VAL B CG1 1 
ATOM   2479 C CG2 . VAL B 1 129 ? 0.666   -8.239  -27.703 1.00 15.92 ? 96  VAL B CG2 1 
ATOM   2480 N N   . MET B 1 130 ? -2.285  -8.489  -29.087 1.00 13.35 ? 97  MET B N   1 
ATOM   2481 C CA  . MET B 1 130 ? -3.321  -7.418  -29.034 1.00 14.79 ? 97  MET B CA  1 
ATOM   2482 C C   . MET B 1 130 ? -3.173  -6.688  -27.710 1.00 13.32 ? 97  MET B C   1 
ATOM   2483 O O   . MET B 1 130 ? -3.244  -7.345  -26.653 1.00 13.96 ? 97  MET B O   1 
ATOM   2484 C CB  . MET B 1 130 ? -4.724  -7.999  -29.140 1.00 14.99 ? 97  MET B CB  1 
ATOM   2485 C CG  . MET B 1 130 ? -4.887  -9.042  -30.257 1.00 15.38 ? 97  MET B CG  1 
ATOM   2486 S SD  . MET B 1 130 ? -6.636  -9.550  -30.289 1.00 16.29 ? 97  MET B SD  1 
ATOM   2487 C CE  . MET B 1 130 ? -7.448  -8.074  -30.903 1.00 16.13 ? 97  MET B CE  1 
ATOM   2488 N N   . ASN B 1 131 ? -2.953  -5.388  -27.781 1.00 14.15 ? 98  ASN B N   1 
ATOM   2489 C CA  . ASN B 1 131 ? -2.779  -4.497  -26.612 1.00 14.90 ? 98  ASN B CA  1 
ATOM   2490 C C   . ASN B 1 131 ? -4.046  -3.652  -26.540 1.00 14.57 ? 98  ASN B C   1 
ATOM   2491 O O   . ASN B 1 131 ? -4.199  -2.713  -27.349 1.00 16.00 ? 98  ASN B O   1 
ATOM   2492 C CB  . ASN B 1 131 ? -1.523  -3.629  -26.720 1.00 16.20 ? 98  ASN B CB  1 
ATOM   2493 C CG  . ASN B 1 131 ? -0.257  -4.423  -26.440 1.00 19.20 ? 98  ASN B CG  1 
ATOM   2494 O OD1 . ASN B 1 131 ? -0.063  -4.905  -25.316 1.00 21.93 ? 98  ASN B OD1 1 
ATOM   2495 N ND2 . ASN B 1 131 ? 0.640   -4.473  -27.409 1.00 19.45 ? 98  ASN B ND2 1 
ATOM   2496 N N   . PHE B 1 132 ? -4.908  -3.977  -25.589 1.00 14.57 ? 99  PHE B N   1 
ATOM   2497 C CA  . PHE B 1 132 ? -6.222  -3.316  -25.435 1.00 14.37 ? 99  PHE B CA  1 
ATOM   2498 C C   . PHE B 1 132 ? -6.044  -2.037  -24.627 1.00 15.01 ? 99  PHE B C   1 
ATOM   2499 O O   . PHE B 1 132 ? -5.159  -1.993  -23.750 1.00 14.45 ? 99  PHE B O   1 
ATOM   2500 C CB  . PHE B 1 132 ? -7.265  -4.230  -24.822 1.00 14.50 ? 99  PHE B CB  1 
ATOM   2501 C CG  . PHE B 1 132 ? -7.744  -5.326  -25.731 1.00 14.16 ? 99  PHE B CG  1 
ATOM   2502 C CD1 . PHE B 1 132 ? -7.077  -6.534  -25.773 1.00 16.22 ? 99  PHE B CD1 1 
ATOM   2503 C CD2 . PHE B 1 132 ? -8.847  -5.130  -26.529 1.00 15.42 ? 99  PHE B CD2 1 
ATOM   2504 C CE1 . PHE B 1 132 ? -7.523  -7.529  -26.622 1.00 14.79 ? 99  PHE B CE1 1 
ATOM   2505 C CE2 . PHE B 1 132 ? -9.270  -6.122  -27.388 1.00 15.56 ? 99  PHE B CE2 1 
ATOM   2506 C CZ  . PHE B 1 132 ? -8.603  -7.301  -27.424 1.00 14.78 ? 99  PHE B CZ  1 
ATOM   2507 N N   . GLU B 1 133 ? -6.920  -1.048  -24.885 1.00 14.34 ? 100 GLU B N   1 
ATOM   2508 C CA  . GLU B 1 133 ? -6.735  0.321   -24.330 1.00 16.72 ? 100 GLU B CA  1 
ATOM   2509 C C   . GLU B 1 133 ? -6.821  0.297   -22.796 1.00 19.76 ? 100 GLU B C   1 
ATOM   2510 O O   . GLU B 1 133 ? -6.317  1.245   -22.207 1.00 21.91 ? 100 GLU B O   1 
ATOM   2511 C CB  . GLU B 1 133 ? -7.764  1.296   -24.893 1.00 18.03 ? 100 GLU B CB  1 
ATOM   2512 C CG  . GLU B 1 133 ? -9.143  0.932   -24.483 1.00 20.05 ? 100 GLU B CG  1 
ATOM   2513 C CD  . GLU B 1 133 ? -10.223 1.882   -24.939 1.00 24.75 ? 100 GLU B CD  1 
ATOM   2514 O OE1 . GLU B 1 133 ? -10.443 2.024   -26.165 1.00 19.49 ? 100 GLU B OE1 1 
ATOM   2515 O OE2 . GLU B 1 133 ? -10.833 2.482   -24.047 1.00 31.78 ? 100 GLU B OE2 1 
ATOM   2516 N N   . ASP B 1 134 ? -7.367  -0.744  -22.147 1.00 17.82 ? 101 ASP B N   1 
ATOM   2517 C CA  . ASP B 1 134 ? -7.497  -0.733  -20.668 1.00 18.78 ? 101 ASP B CA  1 
ATOM   2518 C C   . ASP B 1 134 ? -6.471  -1.672  -20.047 1.00 19.67 ? 101 ASP B C   1 
ATOM   2519 O O   . ASP B 1 134 ? -6.658  -2.047  -18.862 1.00 20.31 ? 101 ASP B O   1 
ATOM   2520 C CB  . ASP B 1 134 ? -8.919  -1.060  -20.228 1.00 18.32 ? 101 ASP B CB  1 
ATOM   2521 C CG  . ASP B 1 134 ? -9.369  -2.462  -20.600 1.00 19.32 ? 101 ASP B CG  1 
ATOM   2522 O OD1 . ASP B 1 134 ? -8.618  -3.143  -21.380 1.00 21.76 ? 101 ASP B OD1 1 
ATOM   2523 O OD2 . ASP B 1 134 ? -10.475 -2.831  -20.186 1.00 18.32 ? 101 ASP B OD2 1 
ATOM   2524 N N   . GLY B 1 135 ? -5.410  -2.025  -20.785 1.00 20.72 ? 102 GLY B N   1 
ATOM   2525 C CA  . GLY B 1 135 ? -4.289  -2.815  -20.239 1.00 19.52 ? 102 GLY B CA  1 
ATOM   2526 C C   . GLY B 1 135 ? -4.478  -4.312  -20.487 1.00 19.47 ? 102 GLY B C   1 
ATOM   2527 O O   . GLY B 1 135 ? -3.504  -5.070  -20.353 1.00 18.36 ? 102 GLY B O   1 
ATOM   2528 N N   . GLY B 1 136 ? -5.659  -4.753  -20.895 1.00 19.25 ? 103 GLY B N   1 
ATOM   2529 C CA  . GLY B 1 136 ? -5.836  -6.169  -21.280 1.00 16.82 ? 103 GLY B CA  1 
ATOM   2530 C C   . GLY B 1 136 ? -4.841  -6.537  -22.405 1.00 15.10 ? 103 GLY B C   1 
ATOM   2531 O O   . GLY B 1 136 ? -4.612  -5.743  -23.319 1.00 16.06 ? 103 GLY B O   1 
ATOM   2532 N N   . VAL B 1 137 ? -4.346  -7.771  -22.427 1.00 15.27 ? 104 VAL B N   1 
ATOM   2533 C CA  . VAL B 1 137 ? -3.402  -8.222  -23.482 1.00 15.70 ? 104 VAL B CA  1 
ATOM   2534 C C   . VAL B 1 137 ? -3.793  -9.646  -23.902 1.00 15.93 ? 104 VAL B C   1 
ATOM   2535 O O   . VAL B 1 137 ? -4.140  -10.475 -23.042 1.00 16.42 ? 104 VAL B O   1 
ATOM   2536 C CB  . VAL B 1 137 ? -1.944  -8.157  -23.008 1.00 18.60 ? 104 VAL B CB  1 
ATOM   2537 C CG1 . VAL B 1 137 ? -1.000  -8.651  -24.078 1.00 18.10 ? 104 VAL B CG1 1 
ATOM   2538 C CG2 . VAL B 1 137 ? -1.539  -6.736  -22.554 1.00 21.80 ? 104 VAL B CG2 1 
ATOM   2539 N N   . VAL B 1 138 ? -3.759  -9.916  -25.210 1.00 15.35 ? 105 VAL B N   1 
ATOM   2540 C CA  . VAL B 1 138 ? -3.865  -11.299 -25.747 1.00 15.43 ? 105 VAL B CA  1 
ATOM   2541 C C   . VAL B 1 138 ? -2.605  -11.572 -26.571 1.00 13.16 ? 105 VAL B C   1 
ATOM   2542 O O   . VAL B 1 138 ? -2.205  -10.733 -27.365 1.00 13.10 ? 105 VAL B O   1 
ATOM   2543 C CB  . VAL B 1 138 ? -5.101  -11.505 -26.639 1.00 16.97 ? 105 VAL B CB  1 
ATOM   2544 C CG1 . VAL B 1 138 ? -5.117  -12.908 -27.215 1.00 17.10 ? 105 VAL B CG1 1 
ATOM   2545 C CG2 . VAL B 1 138 ? -6.408  -11.249 -25.901 1.00 18.38 ? 105 VAL B CG2 1 
ATOM   2546 N N   . THR B 1 139 ? -1.997  -12.735 -26.334 1.00 13.91 ? 106 THR B N   1 
ATOM   2547 C CA  . THR B 1 139 ? -0.917  -13.243 -27.185 1.00 14.47 ? 106 THR B CA  1 
ATOM   2548 C C   . THR B 1 139 ? -1.401  -14.537 -27.810 1.00 13.25 ? 106 THR B C   1 
ATOM   2549 O O   . THR B 1 139 ? -2.189  -15.209 -27.193 1.00 13.88 ? 106 THR B O   1 
ATOM   2550 C CB  . THR B 1 139 ? 0.429   -13.458 -26.479 1.00 16.30 ? 106 THR B CB  1 
ATOM   2551 O OG1 . THR B 1 139 ? 0.353   -14.416 -25.422 1.00 17.80 ? 106 THR B OG1 1 
ATOM   2552 C CG2 . THR B 1 139 ? 0.986   -12.147 -25.955 1.00 15.29 ? 106 THR B CG2 1 
ATOM   2553 N N   . VAL B 1 140 ? -1.019  -14.770 -29.057 1.00 13.09 ? 107 VAL B N   1 
ATOM   2554 C CA  . VAL B 1 140 ? -1.464  -15.983 -29.792 1.00 13.44 ? 107 VAL B CA  1 
ATOM   2555 C C   . VAL B 1 140 ? -0.252  -16.616 -30.457 1.00 15.25 ? 107 VAL B C   1 
ATOM   2556 O O   . VAL B 1 140 ? 0.570   -15.866 -31.020 1.00 13.35 ? 107 VAL B O   1 
ATOM   2557 C CB  . VAL B 1 140 ? -2.541  -15.637 -30.843 1.00 12.74 ? 107 VAL B CB  1 
ATOM   2558 C CG1 . VAL B 1 140 ? -3.042  -16.864 -31.555 1.00 13.99 ? 107 VAL B CG1 1 
ATOM   2559 C CG2 . VAL B 1 140 ? -3.688  -14.827 -30.322 1.00 13.88 ? 107 VAL B CG2 1 
ATOM   2560 N N   . THR B 1 141 ? -0.239  -17.948 -30.531 1.00 14.18 ? 108 THR B N   1 
ATOM   2561 C CA  . THR B 1 141 ? 0.631   -18.697 -31.466 1.00 15.23 ? 108 THR B CA  1 
ATOM   2562 C C   . THR B 1 141 ? -0.233  -19.688 -32.225 1.00 14.94 ? 108 THR B C   1 
ATOM   2563 O O   . THR B 1 141 ? -1.183  -20.191 -31.661 1.00 13.67 ? 108 THR B O   1 
ATOM   2564 C CB  . THR B 1 141 ? 1.823   -19.366 -30.792 1.00 16.50 ? 108 THR B CB  1 
ATOM   2565 O OG1 . THR B 1 141 ? 1.357   -20.380 -29.903 1.00 18.48 ? 108 THR B OG1 1 
ATOM   2566 C CG2 . THR B 1 141 ? 2.667   -18.379 -30.018 1.00 17.35 ? 108 THR B CG2 1 
ATOM   2567 N N   . GLN B 1 142 ? 0.077   -19.899 -33.512 1.00 14.81 ? 109 GLN B N   1 
ATOM   2568 C CA  . GLN B 1 142 ? -0.854  -20.632 -34.373 1.00 13.35 ? 109 GLN B CA  1 
ATOM   2569 C C   . GLN B 1 142 ? -0.053  -21.362 -35.441 1.00 15.13 ? 109 GLN B C   1 
ATOM   2570 O O   . GLN B 1 142 ? 0.893   -20.795 -36.023 1.00 14.53 ? 109 GLN B O   1 
ATOM   2571 C CB  . GLN B 1 142 ? -1.908  -19.719 -34.989 1.00 13.17 ? 109 GLN B CB  1 
ATOM   2572 C CG  . GLN B 1 142 ? -3.119  -20.471 -35.580 1.00 13.17 ? 109 GLN B CG  1 
ATOM   2573 C CD  . GLN B 1 142 ? -3.127  -20.882 -37.031 1.00 13.19 ? 109 GLN B CD  1 
ATOM   2574 O OE1 . GLN B 1 142 ? -4.188  -21.201 -37.626 1.00 14.86 ? 109 GLN B OE1 1 
ATOM   2575 N NE2 . GLN B 1 142 ? -1.973  -20.949 -37.611 1.00 13.07 ? 109 GLN B NE2 1 
ATOM   2576 N N   . ASP B 1 143 ? -0.431  -22.615 -35.692 1.00 14.08 ? 110 ASP B N   1 
ATOM   2577 C CA  . ASP B 1 143 ? 0.104   -23.369 -36.822 1.00 15.00 ? 110 ASP B CA  1 
ATOM   2578 C C   . ASP B 1 143 ? -1.004  -23.673 -37.819 1.00 13.98 ? 110 ASP B C   1 
ATOM   2579 O O   . ASP B 1 143 ? -2.131  -24.084 -37.392 1.00 13.98 ? 110 ASP B O   1 
ATOM   2580 C CB  . ASP B 1 143 ? 0.726   -24.674 -36.338 1.00 15.66 ? 110 ASP B CB  1 
ATOM   2581 C CG  . ASP B 1 143 ? 1.557   -25.335 -37.414 1.00 17.77 ? 110 ASP B CG  1 
ATOM   2582 O OD1 . ASP B 1 143 ? 1.001   -25.998 -38.253 1.00 24.44 ? 110 ASP B OD1 1 
ATOM   2583 O OD2 . ASP B 1 143 ? 2.751   -25.223 -37.334 1.00 23.58 ? 110 ASP B OD2 1 
ATOM   2584 N N   . SER B 1 144 ? -0.685  -23.483 -39.087 1.00 13.39 ? 111 SER B N   1 
ATOM   2585 C CA  . SER B 1 144 ? -1.568  -23.764 -40.219 1.00 13.36 ? 111 SER B CA  1 
ATOM   2586 C C   . SER B 1 144 ? -0.896  -24.740 -41.191 1.00 13.98 ? 111 SER B C   1 
ATOM   2587 O O   . SER B 1 144 ? 0.272   -24.495 -41.569 1.00 12.52 ? 111 SER B O   1 
ATOM   2588 C CB  . SER B 1 144 ? -1.945  -22.453 -40.911 1.00 12.25 ? 111 SER B CB  1 
ATOM   2589 O OG  . SER B 1 144 ? -2.673  -21.612 -40.009 1.00 12.11 ? 111 SER B OG  1 
ATOM   2590 N N   . SER B 1 145 ? -1.617  -25.767 -41.654 1.00 14.24 ? 112 SER B N   1 
ATOM   2591 C CA  . SER B 1 145 ? -1.087  -26.724 -42.651 1.00 15.82 ? 112 SER B CA  1 
ATOM   2592 C C   . SER B 1 145 ? -2.256  -27.231 -43.479 1.00 17.44 ? 112 SER B C   1 
ATOM   2593 O O   . SER B 1 145 ? -3.410  -26.913 -43.142 1.00 14.17 ? 112 SER B O   1 
ATOM   2594 C CB  . SER B 1 145 ? -0.358  -27.848 -41.998 1.00 16.63 ? 112 SER B CB  1 
ATOM   2595 O OG  . SER B 1 145 ? -1.222  -28.416 -41.067 1.00 20.15 ? 112 SER B OG  1 
ATOM   2596 N N   . LEU B 1 146 ? -1.953  -27.918 -44.570 1.00 16.37 ? 113 LEU B N   1 
ATOM   2597 C CA  . LEU B 1 146 ? -2.970  -28.466 -45.494 1.00 17.77 ? 113 LEU B CA  1 
ATOM   2598 C C   . LEU B 1 146 ? -2.685  -29.961 -45.484 1.00 19.26 ? 113 LEU B C   1 
ATOM   2599 O O   . LEU B 1 146 ? -1.505  -30.335 -45.730 1.00 19.67 ? 113 LEU B O   1 
ATOM   2600 C CB  . LEU B 1 146 ? -2.836  -27.813 -46.864 1.00 21.53 ? 113 LEU B CB  1 
ATOM   2601 C CG  . LEU B 1 146 ? -3.767  -28.326 -47.976 1.00 29.65 ? 113 LEU B CG  1 
ATOM   2602 C CD1 . LEU B 1 146 ? -5.167  -27.918 -47.731 1.00 35.31 ? 113 LEU B CD1 1 
ATOM   2603 C CD2 . LEU B 1 146 ? -3.351  -27.784 -49.340 1.00 32.77 ? 113 LEU B CD2 1 
ATOM   2604 N N   . GLN B 1 147 ? -3.628  -30.744 -44.980 1.00 17.06 ? 114 GLN B N   1 
ATOM   2605 C CA  . GLN B 1 147 ? -3.512  -32.211 -44.908 1.00 19.90 ? 114 GLN B CA  1 
ATOM   2606 C C   . GLN B 1 147 ? -4.761  -32.795 -45.549 1.00 19.73 ? 114 GLN B C   1 
ATOM   2607 O O   . GLN B 1 147 ? -5.883  -32.399 -45.163 1.00 18.62 ? 114 GLN B O   1 
ATOM   2608 C CB  . GLN B 1 147 ? -3.331  -32.628 -43.451 1.00 23.37 ? 114 GLN B CB  1 
ATOM   2609 C CG  . GLN B 1 147 ? -2.014  -32.090 -42.873 1.00 27.52 ? 114 GLN B CG  1 
ATOM   2610 C CD  . GLN B 1 147 ? -1.908  -32.216 -41.372 1.00 31.87 ? 114 GLN B CD  1 
ATOM   2611 O OE1 . GLN B 1 147 ? -1.366  -31.353 -40.683 1.00 37.75 ? 114 GLN B OE1 1 
ATOM   2612 N NE2 . GLN B 1 147 ? -2.411  -33.314 -40.838 1.00 40.36 ? 114 GLN B NE2 1 
ATOM   2613 N N   . ASP B 1 148 ? -4.562  -33.717 -46.486 1.00 21.57 ? 115 ASP B N   1 
ATOM   2614 C CA  . ASP B 1 148 ? -5.670  -34.450 -47.132 1.00 20.99 ? 115 ASP B CA  1 
ATOM   2615 C C   . ASP B 1 148 ? -6.775  -33.505 -47.634 1.00 16.62 ? 115 ASP B C   1 
ATOM   2616 O O   . ASP B 1 148 ? -7.990  -33.793 -47.423 1.00 18.27 ? 115 ASP B O   1 
ATOM   2617 C CB  . ASP B 1 148 ? -6.245  -35.487 -46.174 1.00 19.35 ? 115 ASP B CB  1 
ATOM   2618 C CG  . ASP B 1 148 ? -7.097  -36.484 -46.950 1.00 21.34 ? 115 ASP B CG  1 
ATOM   2619 O OD1 . ASP B 1 148 ? -6.869  -36.643 -48.175 1.00 22.38 ? 115 ASP B OD1 1 
ATOM   2620 O OD2 . ASP B 1 148 ? -8.013  -37.067 -46.349 1.00 19.68 ? 115 ASP B OD2 1 
ATOM   2621 N N   . GLY B 1 149 ? -6.372  -32.429 -48.300 1.00 19.30 ? 116 GLY B N   1 
ATOM   2622 C CA  . GLY B 1 149 ? -7.333  -31.547 -48.974 1.00 18.48 ? 116 GLY B CA  1 
ATOM   2623 C C   . GLY B 1 149 ? -8.030  -30.561 -48.058 1.00 17.97 ? 116 GLY B C   1 
ATOM   2624 O O   . GLY B 1 149 ? -8.946  -29.900 -48.593 1.00 17.15 ? 116 GLY B O   1 
ATOM   2625 N N   . GLU B 1 150 ? -7.707  -30.507 -46.761 1.00 19.11 ? 117 GLU B N   1 
ATOM   2626 C CA  . GLU B 1 150 ? -8.340  -29.537 -45.829 1.00 20.20 ? 117 GLU B CA  1 
ATOM   2627 C C   . GLU B 1 150 ? -7.245  -28.782 -45.084 1.00 17.80 ? 117 GLU B C   1 
ATOM   2628 O O   . GLU B 1 150 ? -6.194  -29.366 -44.727 1.00 16.24 ? 117 GLU B O   1 
ATOM   2629 C CB  . GLU B 1 150 ? -9.237  -30.140 -44.736 1.00 23.97 ? 117 GLU B CB  1 
ATOM   2630 C CG  . GLU B 1 150 ? -10.306 -31.060 -45.239 1.00 28.40 ? 117 GLU B CG  1 
ATOM   2631 C CD  . GLU B 1 150 ? -11.409 -31.348 -44.227 1.00 29.45 ? 117 GLU B CD  1 
ATOM   2632 O OE1 . GLU B 1 150 ? -12.531 -31.595 -44.683 1.00 30.91 ? 117 GLU B OE1 1 
ATOM   2633 O OE2 . GLU B 1 150 ? -11.158 -31.252 -43.021 1.00 27.82 ? 117 GLU B OE2 1 
ATOM   2634 N N   . PHE B 1 151 ? -7.558  -27.567 -44.687 1.00 13.98 ? 118 PHE B N   1 
ATOM   2635 C CA  . PHE B 1 151 ? -6.643  -26.818 -43.814 1.00 14.40 ? 118 PHE B CA  1 
ATOM   2636 C C   . PHE B 1 151 ? -6.805  -27.322 -42.393 1.00 14.83 ? 118 PHE B C   1 
ATOM   2637 O O   . PHE B 1 151 ? -7.964  -27.601 -41.976 1.00 15.82 ? 118 PHE B O   1 
ATOM   2638 C CB  . PHE B 1 151 ? -6.946  -25.320 -43.909 1.00 12.96 ? 118 PHE B CB  1 
ATOM   2639 C CG  . PHE B 1 151 ? -6.680  -24.662 -45.236 1.00 12.74 ? 118 PHE B CG  1 
ATOM   2640 C CD1 . PHE B 1 151 ? -5.386  -24.608 -45.743 1.00 12.78 ? 118 PHE B CD1 1 
ATOM   2641 C CD2 . PHE B 1 151 ? -7.684  -24.007 -45.965 1.00 12.59 ? 118 PHE B CD2 1 
ATOM   2642 C CE1 . PHE B 1 151 ? -5.145  -23.970 -46.940 1.00 11.68 ? 118 PHE B CE1 1 
ATOM   2643 C CE2 . PHE B 1 151 ? -7.443  -23.406 -47.190 1.00 10.93 ? 118 PHE B CE2 1 
ATOM   2644 C CZ  . PHE B 1 151 ? -6.155  -23.361 -47.663 1.00 11.85 ? 118 PHE B CZ  1 
ATOM   2645 N N   . ILE B 1 152 ? -5.695  -27.348 -41.650 1.00 14.09 ? 119 ILE B N   1 
ATOM   2646 C CA  . ILE B 1 152 ? -5.640  -27.806 -40.249 1.00 15.03 ? 119 ILE B CA  1 
ATOM   2647 C C   . ILE B 1 152 ? -5.030  -26.671 -39.452 1.00 13.40 ? 119 ILE B C   1 
ATOM   2648 O O   . ILE B 1 152 ? -3.952  -26.232 -39.795 1.00 14.26 ? 119 ILE B O   1 
ATOM   2649 C CB  . ILE B 1 152 ? -4.861  -29.116 -40.049 1.00 15.77 ? 119 ILE B CB  1 
ATOM   2650 C CG1 . ILE B 1 152 ? -5.381  -30.306 -40.887 1.00 21.23 ? 119 ILE B CG1 1 
ATOM   2651 C CG2 . ILE B 1 152 ? -4.788  -29.433 -38.542 1.00 15.56 ? 119 ILE B CG2 1 
ATOM   2652 C CD1 . ILE B 1 152 ? -6.833  -30.787 -40.596 1.00 22.36 ? 119 ILE B CD1 1 
ATOM   2653 N N   . TYR B 1 153 ? -5.772  -26.137 -38.491 1.00 14.77 ? 120 TYR B N   1 
ATOM   2654 C CA  . TYR B 1 153 ? -5.347  -24.975 -37.664 1.00 13.11 ? 120 TYR B CA  1 
ATOM   2655 C C   . TYR B 1 153 ? -5.223  -25.402 -36.201 1.00 12.60 ? 120 TYR B C   1 
ATOM   2656 O O   . TYR B 1 153 ? -6.148  -26.044 -35.674 1.00 13.57 ? 120 TYR B O   1 
ATOM   2657 C CB  . TYR B 1 153 ? -6.332  -23.821 -37.726 1.00 12.36 ? 120 TYR B CB  1 
ATOM   2658 C CG  . TYR B 1 153 ? -6.602  -23.227 -39.090 1.00 12.24 ? 120 TYR B CG  1 
ATOM   2659 C CD1 . TYR B 1 153 ? -5.724  -23.312 -40.156 1.00 12.48 ? 120 TYR B CD1 1 
ATOM   2660 C CD2 . TYR B 1 153 ? -7.784  -22.534 -39.307 1.00 12.78 ? 120 TYR B CD2 1 
ATOM   2661 C CE1 . TYR B 1 153 ? -6.010  -22.744 -41.376 1.00 12.69 ? 120 TYR B CE1 1 
ATOM   2662 C CE2 . TYR B 1 153 ? -8.068  -21.922 -40.522 1.00 13.30 ? 120 TYR B CE2 1 
ATOM   2663 C CZ  . TYR B 1 153 ? -7.176  -22.015 -41.558 1.00 12.10 ? 120 TYR B CZ  1 
ATOM   2664 O OH  . TYR B 1 153 ? -7.480  -21.478 -42.784 1.00 13.05 ? 120 TYR B OH  1 
ATOM   2665 N N   . LYS B 1 154 ? -4.095  -25.096 -35.551 1.00 13.04 ? 121 LYS B N   1 
ATOM   2666 C CA  . LYS B 1 154 ? -3.904  -25.363 -34.103 1.00 14.20 ? 121 LYS B CA  1 
ATOM   2667 C C   . LYS B 1 154 ? -3.530  -24.022 -33.484 1.00 12.99 ? 121 LYS B C   1 
ATOM   2668 O O   . LYS B 1 154 ? -2.496  -23.430 -33.928 1.00 16.24 ? 121 LYS B O   1 
ATOM   2669 C CB  . LYS B 1 154 ? -2.843  -26.442 -33.872 1.00 16.96 ? 121 LYS B CB  1 
ATOM   2670 C CG  . LYS B 1 154 ? -3.165  -27.798 -34.461 1.00 20.74 ? 121 LYS B CG  1 
ATOM   2671 N N   . VAL B 1 155 ? -4.341  -23.523 -32.557 1.00 13.93 ? 122 VAL B N   1 
ATOM   2672 C CA  . VAL B 1 155 ? -4.190  -22.161 -31.979 1.00 14.33 ? 122 VAL B CA  1 
ATOM   2673 C C   . VAL B 1 155 ? -3.989  -22.237 -30.465 1.00 14.12 ? 122 VAL B C   1 
ATOM   2674 O O   . VAL B 1 155 ? -4.692  -23.026 -29.809 1.00 14.60 ? 122 VAL B O   1 
ATOM   2675 C CB  . VAL B 1 155 ? -5.430  -21.311 -32.273 1.00 16.12 ? 122 VAL B CB  1 
ATOM   2676 C CG1 . VAL B 1 155 ? -5.096  -19.835 -32.109 1.00 16.33 ? 122 VAL B CG1 1 
ATOM   2677 C CG2 . VAL B 1 155 ? -6.024  -21.610 -33.636 1.00 17.61 ? 122 VAL B CG2 1 
ATOM   2678 N N   . LYS B 1 156 ? -3.138  -21.374 -29.920 1.00 15.29 ? 123 LYS B N   1 
ATOM   2679 C CA  . LYS B 1 156 ? -2.916  -21.215 -28.447 1.00 14.97 ? 123 LYS B CA  1 
ATOM   2680 C C   . LYS B 1 156 ? -3.096  -19.745 -28.107 1.00 15.61 ? 123 LYS B C   1 
ATOM   2681 O O   . LYS B 1 156 ? -2.444  -18.882 -28.706 1.00 15.45 ? 123 LYS B O   1 
ATOM   2682 C CB  . LYS B 1 156 ? -1.534  -21.720 -28.026 1.00 18.93 ? 123 LYS B CB  1 
ATOM   2683 C CG  . LYS B 1 156 ? -1.274  -23.163 -28.410 1.00 22.15 ? 123 LYS B CG  1 
ATOM   2684 C CD  . LYS B 1 156 ? 0.161   -23.619 -28.185 1.00 27.31 ? 123 LYS B CD  1 
ATOM   2685 C CE  . LYS B 1 156 ? 0.336   -25.109 -28.372 1.00 31.36 ? 123 LYS B CE  1 
ATOM   2686 N NZ  . LYS B 1 156 ? 1.712   -25.538 -28.030 1.00 35.93 ? 123 LYS B NZ  1 
ATOM   2687 N N   . VAL B 1 157 ? -4.050  -19.440 -27.253 1.00 14.09 ? 124 VAL B N   1 
ATOM   2688 C CA  . VAL B 1 157 ? -4.438  -18.043 -26.961 1.00 14.28 ? 124 VAL B CA  1 
ATOM   2689 C C   . VAL B 1 157 ? -4.126  -17.833 -25.496 1.00 16.37 ? 124 VAL B C   1 
ATOM   2690 O O   . VAL B 1 157 ? -4.495  -18.737 -24.670 1.00 17.13 ? 124 VAL B O   1 
ATOM   2691 C CB  . VAL B 1 157 ? -5.927  -17.860 -27.263 1.00 14.39 ? 124 VAL B CB  1 
ATOM   2692 C CG1 . VAL B 1 157 ? -6.380  -16.459 -26.859 1.00 15.96 ? 124 VAL B CG1 1 
ATOM   2693 C CG2 . VAL B 1 157 ? -6.182  -18.155 -28.705 1.00 15.16 ? 124 VAL B CG2 1 
ATOM   2694 N N   . ARG B 1 158 ? -3.507  -16.723 -25.143 1.00 15.91 ? 125 ARG B N   1 
ATOM   2695 C CA  . ARG B 1 158 ? -3.316  -16.380 -23.723 1.00 15.93 ? 125 ARG B CA  1 
ATOM   2696 C C   . ARG B 1 158 ? -3.750  -14.932 -23.524 1.00 19.08 ? 125 ARG B C   1 
ATOM   2697 O O   . ARG B 1 158 ? -3.091  -14.067 -24.127 1.00 19.58 ? 125 ARG B O   1 
ATOM   2698 C CB  . ARG B 1 158 ? -1.860  -16.588 -23.332 1.00 19.61 ? 125 ARG B CB  1 
ATOM   2699 C CG  . ARG B 1 158 ? -1.397  -18.037 -23.405 1.00 22.59 ? 125 ARG B CG  1 
ATOM   2700 C CD  . ARG B 1 158 ? -1.934  -18.907 -22.251 1.00 26.12 ? 125 ARG B CD  1 
ATOM   2701 N NE  . ARG B 1 158 ? -1.480  -20.262 -22.465 1.00 28.10 ? 125 ARG B NE  1 
ATOM   2702 C CZ  . ARG B 1 158 ? -2.056  -21.364 -21.989 1.00 30.13 ? 125 ARG B CZ  1 
ATOM   2703 N NH1 . ARG B 1 158 ? -3.103  -21.301 -21.183 1.00 32.61 ? 125 ARG B NH1 1 
ATOM   2704 N NH2 . ARG B 1 158 ? -1.545  -22.537 -22.296 1.00 30.18 ? 125 ARG B NH2 1 
ATOM   2705 N N   . GLY B 1 159 ? -4.812  -14.717 -22.724 1.00 17.03 ? 126 GLY B N   1 
ATOM   2706 C CA  . GLY B 1 159 ? -5.310  -13.388 -22.332 1.00 15.99 ? 126 GLY B CA  1 
ATOM   2707 C C   . GLY B 1 159 ? -4.969  -13.101 -20.865 1.00 16.45 ? 126 GLY B C   1 
ATOM   2708 O O   . GLY B 1 159 ? -5.102  -14.019 -20.056 1.00 12.90 ? 126 GLY B O   1 
ATOM   2709 N N   . THR B 1 160 ? -4.545  -11.878 -20.519 1.00 15.00 ? 127 THR B N   1 
ATOM   2710 C CA  . THR B 1 160 ? -4.360  -11.541 -19.085 1.00 16.12 ? 127 THR B CA  1 
ATOM   2711 C C   . THR B 1 160 ? -4.566  -10.065 -18.893 1.00 15.56 ? 127 THR B C   1 
ATOM   2712 O O   . THR B 1 160 ? -4.638  -9.292  -19.885 1.00 14.11 ? 127 THR B O   1 
ATOM   2713 C CB  . THR B 1 160 ? -3.035  -12.054 -18.498 1.00 19.46 ? 127 THR B CB  1 
ATOM   2714 O OG1 . THR B 1 160 ? -3.146  -11.908 -17.073 1.00 21.69 ? 127 THR B OG1 1 
ATOM   2715 C CG2 . THR B 1 160 ? -1.819  -11.280 -18.968 1.00 19.02 ? 127 THR B CG2 1 
ATOM   2716 N N   . ASN B 1 161 ? -4.727  -9.697  -17.629 1.00 15.89 ? 128 ASN B N   1 
ATOM   2717 C CA  . ASN B 1 161 ? -4.827  -8.293  -17.189 1.00 17.51 ? 128 ASN B CA  1 
ATOM   2718 C C   . ASN B 1 161 ? -6.056  -7.573  -17.758 1.00 16.40 ? 128 ASN B C   1 
ATOM   2719 O O   . ASN B 1 161 ? -5.987  -6.307  -17.869 1.00 16.54 ? 128 ASN B O   1 
ATOM   2720 C CB  . ASN B 1 161 ? -3.540  -7.556  -17.525 1.00 17.29 ? 128 ASN B CB  1 
ATOM   2721 C CG  . ASN B 1 161 ? -3.381  -6.292  -16.731 1.00 17.47 ? 128 ASN B CG  1 
ATOM   2722 O OD1 . ASN B 1 161 ? -3.632  -6.250  -15.523 1.00 20.82 ? 128 ASN B OD1 1 
ATOM   2723 N ND2 . ASN B 1 161 ? -2.958  -5.252  -17.392 1.00 17.86 ? 128 ASN B ND2 1 
ATOM   2724 N N   . PHE B 1 162 ? -7.158  -8.299  -18.036 1.00 16.74 ? 129 PHE B N   1 
ATOM   2725 C CA  . PHE B 1 162 ? -8.437  -7.632  -18.357 1.00 16.44 ? 129 PHE B CA  1 
ATOM   2726 C C   . PHE B 1 162 ? -9.066  -7.245  -17.046 1.00 18.29 ? 129 PHE B C   1 
ATOM   2727 O O   . PHE B 1 162 ? -9.195  -8.106  -16.193 1.00 17.70 ? 129 PHE B O   1 
ATOM   2728 C CB  . PHE B 1 162 ? -9.378  -8.512  -19.165 1.00 16.28 ? 129 PHE B CB  1 
ATOM   2729 C CG  . PHE B 1 162 ? -8.898  -8.720  -20.564 1.00 14.98 ? 129 PHE B CG  1 
ATOM   2730 C CD1 . PHE B 1 162 ? -9.113  -7.746  -21.513 1.00 14.64 ? 129 PHE B CD1 1 
ATOM   2731 C CD2 . PHE B 1 162 ? -8.243  -9.893  -20.901 1.00 16.27 ? 129 PHE B CD2 1 
ATOM   2732 C CE1 . PHE B 1 162 ? -8.706  -7.951  -22.812 1.00 15.30 ? 129 PHE B CE1 1 
ATOM   2733 C CE2 . PHE B 1 162 ? -7.772  -10.081 -22.202 1.00 15.41 ? 129 PHE B CE2 1 
ATOM   2734 C CZ  . PHE B 1 162 ? -8.004  -9.095  -23.145 1.00 15.78 ? 129 PHE B CZ  1 
ATOM   2735 N N   . PRO B 1 163 ? -9.420  -5.970  -16.854 1.00 19.67 ? 130 PRO B N   1 
ATOM   2736 C CA  . PRO B 1 163 ? -10.080 -5.565  -15.618 1.00 20.65 ? 130 PRO B CA  1 
ATOM   2737 C C   . PRO B 1 163 ? -11.383 -6.326  -15.431 1.00 19.42 ? 130 PRO B C   1 
ATOM   2738 O O   . PRO B 1 163 ? -12.091 -6.579  -16.389 1.00 18.12 ? 130 PRO B O   1 
ATOM   2739 C CB  . PRO B 1 163 ? -10.306 -4.068  -15.810 1.00 21.21 ? 130 PRO B CB  1 
ATOM   2740 C CG  . PRO B 1 163 ? -9.269  -3.636  -16.828 1.00 21.01 ? 130 PRO B CG  1 
ATOM   2741 C CD  . PRO B 1 163 ? -9.149  -4.826  -17.737 1.00 20.68 ? 130 PRO B CD  1 
ATOM   2742 N N   . SER B 1 164 ? -11.646 -6.718  -14.189 1.00 18.57 ? 131 SER B N   1 
ATOM   2743 C CA  . SER B 1 164 ? -12.832 -7.523  -13.826 1.00 22.17 ? 131 SER B CA  1 
ATOM   2744 C C   . SER B 1 164 ? -14.077 -6.721  -14.158 1.00 19.89 ? 131 SER B C   1 
ATOM   2745 O O   . SER B 1 164 ? -15.072 -7.311  -14.459 1.00 23.59 ? 131 SER B O   1 
ATOM   2746 C CB  . SER B 1 164 ? -12.816 -7.961  -12.378 1.00 25.48 ? 131 SER B CB  1 
ATOM   2747 O OG  . SER B 1 164 ? -12.870 -6.832  -11.526 1.00 25.05 ? 131 SER B OG  1 
ATOM   2748 N N   . ASP B 1 165 ? -14.024 -5.404  -14.102 1.00 20.45 ? 132 ASP B N   1 
ATOM   2749 C CA  . ASP B 1 165 ? -15.240 -4.588  -14.351 1.00 24.91 ? 132 ASP B CA  1 
ATOM   2750 C C   . ASP B 1 165 ? -15.215 -4.060  -15.789 1.00 23.70 ? 132 ASP B C   1 
ATOM   2751 O O   . ASP B 1 165 ? -15.991 -3.154  -16.080 1.00 26.71 ? 132 ASP B O   1 
ATOM   2752 C CB  . ASP B 1 165 ? -15.360 -3.444  -13.339 1.00 26.50 ? 132 ASP B CB  1 
ATOM   2753 C CG  . ASP B 1 165 ? -14.230 -2.426  -13.330 1.00 32.14 ? 132 ASP B CG  1 
ATOM   2754 O OD1 . ASP B 1 165 ? -13.231 -2.654  -13.994 1.00 31.52 ? 132 ASP B OD1 1 
ATOM   2755 O OD2 . ASP B 1 165 ? -14.344 -1.423  -12.593 1.00 38.85 ? 132 ASP B OD2 1 
ATOM   2756 N N   . GLY B 1 166 ? -14.318 -4.554  -16.645 1.00 21.87 ? 133 GLY B N   1 
ATOM   2757 C CA  . GLY B 1 166 ? -14.141 -4.019  -17.998 1.00 20.19 ? 133 GLY B CA  1 
ATOM   2758 C C   . GLY B 1 166 ? -15.044 -4.768  -18.963 1.00 19.56 ? 133 GLY B C   1 
ATOM   2759 O O   . GLY B 1 166 ? -15.620 -5.798  -18.635 1.00 19.09 ? 133 GLY B O   1 
ATOM   2760 N N   . PRO B 1 167 ? -15.174 -4.257  -20.204 1.00 17.23 ? 134 PRO B N   1 
ATOM   2761 C CA  . PRO B 1 167 ? -16.141 -4.799  -21.162 1.00 17.21 ? 134 PRO B CA  1 
ATOM   2762 C C   . PRO B 1 167 ? -15.910 -6.269  -21.552 1.00 17.04 ? 134 PRO B C   1 
ATOM   2763 O O   . PRO B 1 167 ? -16.836 -6.985  -21.921 1.00 19.40 ? 134 PRO B O   1 
ATOM   2764 C CB  . PRO B 1 167 ? -16.003 -3.867  -22.375 1.00 18.91 ? 134 PRO B CB  1 
ATOM   2765 C CG  . PRO B 1 167 ? -14.649 -3.184  -22.202 1.00 19.29 ? 134 PRO B CG  1 
ATOM   2766 C CD  . PRO B 1 167 ? -14.424 -3.114  -20.703 1.00 17.93 ? 134 PRO B CD  1 
ATOM   2767 N N   . VAL B 1 168 ? -14.658 -6.708  -21.530 1.00 17.49 ? 135 VAL B N   1 
ATOM   2768 C CA  . VAL B 1 168 ? -14.327 -8.113  -21.868 1.00 17.50 ? 135 VAL B CA  1 
ATOM   2769 C C   . VAL B 1 168 ? -14.844 -9.058  -20.773 1.00 17.85 ? 135 VAL B C   1 
ATOM   2770 O O   . VAL B 1 168 ? -15.552 -10.028 -21.093 1.00 16.63 ? 135 VAL B O   1 
ATOM   2771 C CB  . VAL B 1 168 ? -12.818 -8.273  -22.118 1.00 18.70 ? 135 VAL B CB  1 
ATOM   2772 C CG1 . VAL B 1 168 ? -12.442 -9.732  -22.250 1.00 17.20 ? 135 VAL B CG1 1 
ATOM   2773 C CG2 . VAL B 1 168 ? -12.354 -7.487  -23.328 1.00 17.89 ? 135 VAL B CG2 1 
ATOM   2774 N N   . MET B 1 169 ? -14.457 -8.841  -19.518 1.00 18.47 ? 136 MET B N   1 
ATOM   2775 C CA  . MET B 1 169 ? -14.883 -9.766  -18.453 1.00 18.20 ? 136 MET B CA  1 
ATOM   2776 C C   . MET B 1 169 ? -16.385 -9.577  -18.196 1.00 18.42 ? 136 MET B C   1 
ATOM   2777 O O   . MET B 1 169 ? -16.990 -10.507 -17.677 1.00 17.57 ? 136 MET B O   1 
ATOM   2778 C CB  . MET B 1 169 ? -14.069 -9.552  -17.180 1.00 17.82 ? 136 MET B CB  1 
ATOM   2779 C CG  . MET B 1 169 ? -12.562 -9.843  -17.375 1.00 20.36 ? 136 MET B CG  1 
ATOM   2780 S SD  . MET B 1 169 ? -12.119 -11.318 -18.365 1.00 19.62 ? 136 MET B SD  1 
ATOM   2781 C CE  . MET B 1 169 ? -12.662 -12.700 -17.375 1.00 20.69 ? 136 MET B CE  1 
ATOM   2782 N N   . GLN B 1 170 ? -16.959 -8.401  -18.469 1.00 19.42 ? 137 GLN B N   1 
ATOM   2783 C CA  . GLN B 1 170 ? -18.413 -8.199  -18.202 1.00 22.03 ? 137 GLN B CA  1 
ATOM   2784 C C   . GLN B 1 170 ? -19.249 -8.558  -19.451 1.00 22.54 ? 137 GLN B C   1 
ATOM   2785 O O   . GLN B 1 170 ? -20.467 -8.369  -19.382 1.00 22.85 ? 137 GLN B O   1 
ATOM   2786 C CB  . GLN B 1 170 ? -18.663 -6.762  -17.732 1.00 23.78 ? 137 GLN B CB  1 
ATOM   2787 C CG  . GLN B 1 170 ? -18.188 -6.465  -16.287 1.00 29.41 ? 137 GLN B CG  1 
ATOM   2788 C CD  . GLN B 1 170 ? -18.748 -7.412  -15.243 1.00 35.38 ? 137 GLN B CD  1 
ATOM   2789 O OE1 . GLN B 1 170 ? -18.016 -8.058  -14.497 1.00 42.43 ? 137 GLN B OE1 1 
ATOM   2790 N NE2 . GLN B 1 170 ? -20.062 -7.565  -15.196 1.00 38.63 ? 137 GLN B NE2 1 
ATOM   2791 N N   . LYS B 1 171 ? -18.637 -8.991  -20.570 1.00 20.87 ? 138 LYS B N   1 
ATOM   2792 C CA  . LYS B 1 171 ? -19.375 -9.365  -21.808 1.00 20.45 ? 138 LYS B CA  1 
ATOM   2793 C C   . LYS B 1 171 ? -20.287 -8.218  -22.254 1.00 20.13 ? 138 LYS B C   1 
ATOM   2794 O O   . LYS B 1 171 ? -21.473 -8.465  -22.515 1.00 18.51 ? 138 LYS B O   1 
ATOM   2795 C CB  . LYS B 1 171 ? -20.169 -10.639 -21.580 1.00 21.94 ? 138 LYS B CB  1 
ATOM   2796 C CG  . LYS B 1 171 ? -19.329 -11.837 -21.197 1.00 25.43 ? 138 LYS B CG  1 
ATOM   2797 C CD  . LYS B 1 171 ? -20.126 -13.097 -21.065 1.00 27.69 ? 138 LYS B CD  1 
ATOM   2798 C CE  . LYS B 1 171 ? -19.401 -14.064 -20.176 1.00 31.14 ? 138 LYS B CE  1 
ATOM   2799 N NZ  . LYS B 1 171 ? -20.149 -15.310 -19.942 1.00 35.92 ? 138 LYS B NZ  1 
ATOM   2800 N N   . LYS B 1 172 ? -19.725 -7.027  -22.458 1.00 19.89 ? 139 LYS B N   1 
ATOM   2801 C CA  . LYS B 1 172 ? -20.445 -5.802  -22.917 1.00 21.11 ? 139 LYS B CA  1 
ATOM   2802 C C   . LYS B 1 172 ? -19.999 -5.438  -24.326 1.00 19.40 ? 139 LYS B C   1 
ATOM   2803 O O   . LYS B 1 172 ? -20.209 -4.294  -24.727 1.00 21.39 ? 139 LYS B O   1 
ATOM   2804 C CB  . LYS B 1 172 ? -20.145 -4.622  -21.986 1.00 22.90 ? 139 LYS B CB  1 
ATOM   2805 C CG  . LYS B 1 172 ? -20.529 -4.831  -20.513 1.00 29.40 ? 139 LYS B CG  1 
ATOM   2806 C CD  . LYS B 1 172 ? -22.022 -4.910  -20.213 1.00 31.87 ? 139 LYS B CD  1 
ATOM   2807 N N   . THR B 1 173 ? -19.420 -6.358  -25.100 1.00 16.10 ? 140 THR B N   1 
ATOM   2808 C CA  . THR B 1 173 ? -18.956 -6.085  -26.478 1.00 15.78 ? 140 THR B CA  1 
ATOM   2809 C C   . THR B 1 173 ? -19.998 -6.557  -27.501 1.00 15.56 ? 140 THR B C   1 
ATOM   2810 O O   . THR B 1 173 ? -20.751 -7.491  -27.201 1.00 18.38 ? 140 THR B O   1 
ATOM   2811 C CB  . THR B 1 173 ? -17.576 -6.726  -26.715 1.00 15.75 ? 140 THR B CB  1 
ATOM   2812 O OG1 . THR B 1 173 ? -17.578 -8.138  -26.785 1.00 17.36 ? 140 THR B OG1 1 
ATOM   2813 C CG2 . THR B 1 173 ? -16.605 -6.338  -25.620 1.00 18.23 ? 140 THR B CG2 1 
ATOM   2814 N N   . MET B 1 174 ? -19.959 -6.022  -28.704 1.00 16.22 ? 141 MET B N   1 
ATOM   2815 C CA  . MET B 1 174 ? -20.962 -6.308  -29.752 1.00 18.56 ? 141 MET B CA  1 
ATOM   2816 C C   . MET B 1 174 ? -20.239 -6.395  -31.072 1.00 17.26 ? 141 MET B C   1 
ATOM   2817 O O   . MET B 1 174 ? -20.794 -5.860  -32.019 1.00 18.76 ? 141 MET B O   1 
ATOM   2818 C CB  . MET B 1 174 ? -21.997 -5.174  -29.935 1.00 23.43 ? 141 MET B CB  1 
ATOM   2819 C CG  . MET B 1 174 ? -22.953 -4.989  -28.804 1.00 33.07 ? 141 MET B CG  1 
ATOM   2820 S SD  . MET B 1 174 ? -24.304 -3.854  -29.357 1.00 50.71 ? 141 MET B SD  1 
ATOM   2821 C CE  . MET B 1 174 ? -23.511 -2.635  -30.413 1.00 49.85 ? 141 MET B CE  1 
ATOM   2822 N N   . GLY B 1 175 ? -19.050 -7.022  -31.138 1.00 17.10 ? 142 GLY B N   1 
ATOM   2823 C CA  . GLY B 1 175 ? -18.468 -7.352  -32.461 1.00 15.14 ? 142 GLY B CA  1 
ATOM   2824 C C   . GLY B 1 175 ? -17.553 -6.264  -33.015 1.00 14.40 ? 142 GLY B C   1 
ATOM   2825 O O   . GLY B 1 175 ? -17.613 -5.079  -32.573 1.00 15.57 ? 142 GLY B O   1 
ATOM   2826 N N   . TRP B 1 176 ? -16.738 -6.626  -34.017 1.00 14.39 ? 143 TRP B N   1 
ATOM   2827 C CA  . TRP B 1 176 ? -15.637 -5.767  -34.532 1.00 13.75 ? 143 TRP B CA  1 
ATOM   2828 C C   . TRP B 1 176 ? -16.097 -4.848  -35.662 1.00 14.83 ? 143 TRP B C   1 
ATOM   2829 O O   . TRP B 1 176 ? -16.694 -5.345  -36.669 1.00 14.81 ? 143 TRP B O   1 
ATOM   2830 C CB  . TRP B 1 176 ? -14.460 -6.609  -34.988 1.00 13.16 ? 143 TRP B CB  1 
ATOM   2831 C CG  . TRP B 1 176 ? -13.774 -7.377  -33.914 1.00 12.29 ? 143 TRP B CG  1 
ATOM   2832 C CD1 . TRP B 1 176 ? -14.041 -8.658  -33.575 1.00 11.22 ? 143 TRP B CD1 1 
ATOM   2833 C CD2 . TRP B 1 176 ? -12.836 -6.882  -32.955 1.00 13.38 ? 143 TRP B CD2 1 
ATOM   2834 N NE1 . TRP B 1 176 ? -13.289 -9.031  -32.505 1.00 13.55 ? 143 TRP B NE1 1 
ATOM   2835 C CE2 . TRP B 1 176 ? -12.524 -7.969  -32.103 1.00 13.32 ? 143 TRP B CE2 1 
ATOM   2836 C CE3 . TRP B 1 176 ? -12.187 -5.652  -32.771 1.00 13.37 ? 143 TRP B CE3 1 
ATOM   2837 C CZ2 . TRP B 1 176 ? -11.592 -7.868  -31.081 1.00 12.41 ? 143 TRP B CZ2 1 
ATOM   2838 C CZ3 . TRP B 1 176 ? -11.253 -5.560  -31.762 1.00 14.44 ? 143 TRP B CZ3 1 
ATOM   2839 C CH2 . TRP B 1 176 ? -10.971 -6.649  -30.930 1.00 13.98 ? 143 TRP B CH2 1 
ATOM   2840 N N   . GLU B 1 177 ? -15.687 -3.580  -35.631 1.00 13.14 ? 144 GLU B N   1 
ATOM   2841 C CA  . GLU B 1 177 ? -15.729 -2.775  -36.868 1.00 16.20 ? 144 GLU B CA  1 
ATOM   2842 C C   . GLU B 1 177 ? -14.758 -3.405  -37.876 1.00 16.41 ? 144 GLU B C   1 
ATOM   2843 O O   . GLU B 1 177 ? -13.785 -4.070  -37.452 1.00 17.58 ? 144 GLU B O   1 
ATOM   2844 C CB  . GLU B 1 177 ? -15.303 -1.324  -36.634 1.00 19.20 ? 144 GLU B CB  1 
ATOM   2845 C CG  . GLU B 1 177 ? -16.105 -0.585  -35.591 1.00 23.29 ? 144 GLU B CG  1 
ATOM   2846 C CD  . GLU B 1 177 ? -17.532 -0.199  -35.922 1.00 29.30 ? 144 GLU B CD  1 
ATOM   2847 O OE1 . GLU B 1 177 ? -18.079 -0.712  -36.896 1.00 32.02 ? 144 GLU B OE1 1 
ATOM   2848 O OE2 . GLU B 1 177 ? -18.084 0.604   -35.162 1.00 30.03 ? 144 GLU B OE2 1 
ATOM   2849 N N   . ALA B 1 178 ? -15.037 -3.220  -39.158 1.00 15.57 ? 145 ALA B N   1 
ATOM   2850 C CA  . ALA B 1 178 ? -14.110 -3.551  -40.244 1.00 16.20 ? 145 ALA B CA  1 
ATOM   2851 C C   . ALA B 1 178 ? -12.744 -2.908  -39.978 1.00 15.68 ? 145 ALA B C   1 
ATOM   2852 O O   . ALA B 1 178 ? -12.659 -1.813  -39.392 1.00 17.21 ? 145 ALA B O   1 
ATOM   2853 C CB  . ALA B 1 178 ? -14.654 -3.131  -41.575 1.00 17.98 ? 145 ALA B CB  1 
ATOM   2854 N N   . SER B 1 179 ? -11.711 -3.697  -40.242 1.00 15.17 ? 146 SER B N   1 
ATOM   2855 C CA  . SER B 1 179 ? -10.289 -3.373  -39.973 1.00 15.69 ? 146 SER B CA  1 
ATOM   2856 C C   . SER B 1 179 ? -9.583  -3.248  -41.320 1.00 16.93 ? 146 SER B C   1 
ATOM   2857 O O   . SER B 1 179 ? -10.018 -3.919  -42.276 1.00 16.16 ? 146 SER B O   1 
ATOM   2858 C CB  . SER B 1 179 ? -9.611  -4.443  -39.133 1.00 16.67 ? 146 SER B CB  1 
ATOM   2859 O OG  . SER B 1 179 ? -10.278 -4.735  -37.915 1.00 17.90 ? 146 SER B OG  1 
ATOM   2860 N N   . SER B 1 180 ? -8.495  -2.496  -41.386 1.00 16.72 ? 147 SER B N   1 
ATOM   2861 C CA  . SER B 1 180 ? -7.562  -2.550  -42.531 1.00 19.44 ? 147 SER B CA  1 
ATOM   2862 C C   . SER B 1 180 ? -6.170  -2.776  -41.968 1.00 18.12 ? 147 SER B C   1 
ATOM   2863 O O   . SER B 1 180 ? -5.674  -1.979  -41.151 1.00 16.26 ? 147 SER B O   1 
ATOM   2864 C CB  . SER B 1 180 ? -7.661  -1.436  -43.530 1.00 24.93 ? 147 SER B CB  1 
ATOM   2865 O OG  . SER B 1 180 ? -7.792  -0.203  -42.952 1.00 34.42 ? 147 SER B OG  1 
ATOM   2866 N N   . GLU B 1 181 ? -5.612  -3.926  -42.308 1.00 16.59 ? 148 GLU B N   1 
ATOM   2867 C CA  . GLU B 1 181 ? -4.328  -4.382  -41.757 1.00 14.59 ? 148 GLU B CA  1 
ATOM   2868 C C   . GLU B 1 181 ? -3.241  -3.917  -42.710 1.00 14.74 ? 148 GLU B C   1 
ATOM   2869 O O   . GLU B 1 181 ? -3.345  -4.207  -43.916 1.00 15.19 ? 148 GLU B O   1 
ATOM   2870 C CB  . GLU B 1 181 ? -4.327  -5.910  -41.613 1.00 14.92 ? 148 GLU B CB  1 
ATOM   2871 C CG  . GLU B 1 181 ? -3.238  -6.436  -40.724 1.00 13.96 ? 148 GLU B CG  1 
ATOM   2872 C CD  . GLU B 1 181 ? -3.249  -7.937  -40.522 1.00 15.79 ? 148 GLU B CD  1 
ATOM   2873 O OE1 . GLU B 1 181 ? -4.195  -8.545  -41.047 1.00 16.17 ? 148 GLU B OE1 1 
ATOM   2874 O OE2 . GLU B 1 181 ? -2.401  -8.485  -39.799 1.00 14.31 ? 148 GLU B OE2 1 
ATOM   2875 N N   . ARG B 1 182 ? -2.259  -3.197  -42.199 1.00 14.62 ? 149 ARG B N   1 
ATOM   2876 C CA  . ARG B 1 182 ? -1.098  -2.755  -42.984 1.00 14.10 ? 149 ARG B CA  1 
ATOM   2877 C C   . ARG B 1 182 ? -0.111  -3.915  -43.055 1.00 13.43 ? 149 ARG B C   1 
ATOM   2878 O O   . ARG B 1 182 ? 0.466   -4.297  -41.991 1.00 14.29 ? 149 ARG B O   1 
ATOM   2879 C CB  . ARG B 1 182 ? -0.422  -1.540  -42.351 1.00 17.16 ? 149 ARG B CB  1 
ATOM   2880 C CG  . ARG B 1 182 ? 0.772   -1.018  -43.143 1.00 23.13 ? 149 ARG B CG  1 
ATOM   2881 C CD  . ARG B 1 182 ? 1.266   0.267   -42.507 1.00 27.06 ? 149 ARG B CD  1 
ATOM   2882 N NE  . ARG B 1 182 ? 1.932   0.078   -41.219 1.00 30.55 ? 149 ARG B NE  1 
ATOM   2883 C CZ  . ARG B 1 182 ? 3.241   -0.172  -41.092 1.00 35.49 ? 149 ARG B CZ  1 
ATOM   2884 N NH1 . ARG B 1 182 ? 4.014   -0.334  -42.160 1.00 38.44 ? 149 ARG B NH1 1 
ATOM   2885 N NH2 . ARG B 1 182 ? 3.773   -0.305  -39.895 1.00 40.66 ? 149 ARG B NH2 1 
ATOM   2886 N N   . MET B 1 183 ? 0.072   -4.474  -44.236 1.00 13.29 ? 150 MET B N   1 
ATOM   2887 C CA  . MET B 1 183 ? 0.917   -5.660  -44.425 1.00 14.25 ? 150 MET B CA  1 
ATOM   2888 C C   . MET B 1 183 ? 2.270   -5.201  -45.003 1.00 14.54 ? 150 MET B C   1 
ATOM   2889 O O   . MET B 1 183 ? 2.339   -4.264  -45.832 1.00 14.91 ? 150 MET B O   1 
ATOM   2890 C CB  . MET B 1 183 ? 0.217   -6.605  -45.378 1.00 15.49 ? 150 MET B CB  1 
ATOM   2891 C CG  . MET B 1 183 ? -1.253  -6.763  -45.097 1.00 16.65 ? 150 MET B CG  1 
ATOM   2892 S SD  . MET B 1 183 ? -1.537  -7.678  -43.586 1.00 16.45 ? 150 MET B SD  1 
ATOM   2893 C CE  . MET B 1 183 ? -0.500  -9.122  -43.849 1.00 17.67 ? 150 MET B CE  1 
ATOM   2894 N N   . TYR B 1 184 ? 3.345   -5.782  -44.498 1.00 15.42 ? 151 TYR B N   1 
ATOM   2895 C CA  . TYR B 1 184 ? 4.706   -5.407  -44.942 1.00 15.16 ? 151 TYR B CA  1 
ATOM   2896 C C   . TYR B 1 184 ? 5.737   -6.493  -44.607 1.00 15.11 ? 151 TYR B C   1 
ATOM   2897 O O   . TYR B 1 184 ? 5.617   -7.207  -43.612 1.00 16.00 ? 151 TYR B O   1 
ATOM   2898 C CB  . TYR B 1 184 ? 5.048   -4.046  -44.376 1.00 16.48 ? 151 TYR B CB  1 
ATOM   2899 C CG  . TYR B 1 184 ? 5.110   -3.989  -42.881 1.00 15.66 ? 151 TYR B CG  1 
ATOM   2900 C CD1 . TYR B 1 184 ? 3.967   -3.766  -42.144 1.00 18.22 ? 151 TYR B CD1 1 
ATOM   2901 C CD2 . TYR B 1 184 ? 6.324   -4.104  -42.208 1.00 17.06 ? 151 TYR B CD2 1 
ATOM   2902 C CE1 . TYR B 1 184 ? 4.008   -3.689  -40.760 1.00 21.10 ? 151 TYR B CE1 1 
ATOM   2903 C CE2 . TYR B 1 184 ? 6.380   -4.036  -40.825 1.00 17.51 ? 151 TYR B CE2 1 
ATOM   2904 C CZ  . TYR B 1 184 ? 5.221   -3.846  -40.105 1.00 21.11 ? 151 TYR B CZ  1 
ATOM   2905 O OH  . TYR B 1 184 ? 5.300   -3.772  -38.755 1.00 22.16 ? 151 TYR B OH  1 
ATOM   2906 N N   . PRO B 1 185 ? 6.730   -6.661  -45.503 1.00 14.08 ? 152 PRO B N   1 
ATOM   2907 C CA  . PRO B 1 185 ? 7.807   -7.630  -45.312 1.00 14.61 ? 152 PRO B CA  1 
ATOM   2908 C C   . PRO B 1 185 ? 8.798   -7.029  -44.322 1.00 16.12 ? 152 PRO B C   1 
ATOM   2909 O O   . PRO B 1 185 ? 9.124   -5.857  -44.416 1.00 14.18 ? 152 PRO B O   1 
ATOM   2910 C CB  . PRO B 1 185 ? 8.378   -7.804  -46.711 1.00 14.69 ? 152 PRO B CB  1 
ATOM   2911 C CG  . PRO B 1 185 ? 8.186   -6.426  -47.338 1.00 14.93 ? 152 PRO B CG  1 
ATOM   2912 C CD  . PRO B 1 185 ? 6.869   -5.920  -46.772 1.00 14.67 ? 152 PRO B CD  1 
ATOM   2913 N N   . GLU B 1 186 ? 9.251   -7.813  -43.375 1.00 15.22 ? 153 GLU B N   1 
ATOM   2914 C CA  . GLU B 1 186 ? 10.337  -7.346  -42.474 1.00 16.25 ? 153 GLU B CA  1 
ATOM   2915 C C   . GLU B 1 186 ? 11.042  -8.571  -41.913 1.00 16.60 ? 153 GLU B C   1 
ATOM   2916 O O   . GLU B 1 186 ? 10.333  -9.533  -41.525 1.00 16.12 ? 153 GLU B O   1 
ATOM   2917 C CB  . GLU B 1 186 ? 9.758   -6.513  -41.340 1.00 18.48 ? 153 GLU B CB  1 
ATOM   2918 C CG  . GLU B 1 186 ? 10.788  -5.791  -40.498 1.00 20.36 ? 153 GLU B CG  1 
ATOM   2919 C CD  . GLU B 1 186 ? 10.157  -4.880  -39.464 1.00 22.53 ? 153 GLU B CD  1 
ATOM   2920 O OE1 . GLU B 1 186 ? 9.503   -5.388  -38.579 1.00 22.50 ? 153 GLU B OE1 1 
ATOM   2921 O OE2 . GLU B 1 186 ? 10.210  -3.678  -39.648 1.00 29.49 ? 153 GLU B OE2 1 
ATOM   2922 N N   . ASP B 1 187 ? 12.366  -8.550  -41.922 1.00 17.93 ? 154 ASP B N   1 
ATOM   2923 C CA  . ASP B 1 187 ? 13.138  -9.623  -41.253 1.00 18.46 ? 154 ASP B CA  1 
ATOM   2924 C C   . ASP B 1 187 ? 12.795  -11.004 -41.842 1.00 18.30 ? 154 ASP B C   1 
ATOM   2925 O O   . ASP B 1 187 ? 12.853  -11.977 -41.095 1.00 18.32 ? 154 ASP B O   1 
ATOM   2926 C CB  . ASP B 1 187 ? 12.755  -9.691  -39.773 1.00 23.26 ? 154 ASP B CB  1 
ATOM   2927 C CG  . ASP B 1 187 ? 12.972  -8.442  -38.952 1.00 27.92 ? 154 ASP B CG  1 
ATOM   2928 O OD1 . ASP B 1 187 ? 14.035  -7.848  -39.115 1.00 24.41 ? 154 ASP B OD1 1 
ATOM   2929 O OD2 . ASP B 1 187 ? 12.078  -8.131  -38.081 1.00 33.69 ? 154 ASP B OD2 1 
ATOM   2930 N N   . GLY B 1 188 ? 12.446  -11.099 -43.126 1.00 15.29 ? 155 GLY B N   1 
ATOM   2931 C CA  . GLY B 1 188 ? 12.230  -12.399 -43.799 1.00 14.77 ? 155 GLY B CA  1 
ATOM   2932 C C   . GLY B 1 188 ? 10.875  -12.977 -43.465 1.00 13.78 ? 155 GLY B C   1 
ATOM   2933 O O   . GLY B 1 188 ? 10.635  -14.157 -43.660 1.00 15.90 ? 155 GLY B O   1 
ATOM   2934 N N   . ALA B 1 189 ? 9.952   -12.166 -42.973 1.00 13.81 ? 156 ALA B N   1 
ATOM   2935 C CA  . ALA B 1 189 ? 8.591   -12.609 -42.613 1.00 14.18 ? 156 ALA B CA  1 
ATOM   2936 C C   . ALA B 1 189 ? 7.588   -11.573 -43.121 1.00 14.08 ? 156 ALA B C   1 
ATOM   2937 O O   . ALA B 1 189 ? 8.003   -10.442 -43.488 1.00 12.01 ? 156 ALA B O   1 
ATOM   2938 C CB  . ALA B 1 189 ? 8.445   -12.733 -41.135 1.00 14.36 ? 156 ALA B CB  1 
ATOM   2939 N N   . LEU B 1 190 ? 6.307   -11.909 -42.990 1.00 11.58 ? 157 LEU B N   1 
ATOM   2940 C CA  . LEU B 1 190 ? 5.240   -10.960 -43.310 1.00 13.35 ? 157 LEU B CA  1 
ATOM   2941 C C   . LEU B 1 190 ? 4.647   -10.443 -42.013 1.00 15.22 ? 157 LEU B C   1 
ATOM   2942 O O   . LEU B 1 190 ? 4.242   -11.227 -41.150 1.00 13.48 ? 157 LEU B O   1 
ATOM   2943 C CB  . LEU B 1 190 ? 4.230   -11.645 -44.227 1.00 14.12 ? 157 LEU B CB  1 
ATOM   2944 C CG  . LEU B 1 190 ? 2.967   -10.857 -44.573 1.00 15.02 ? 157 LEU B CG  1 
ATOM   2945 C CD1 . LEU B 1 190 ? 3.319   -9.604  -45.350 1.00 15.63 ? 157 LEU B CD1 1 
ATOM   2946 C CD2 . LEU B 1 190 ? 1.965   -11.724 -45.355 1.00 15.40 ? 157 LEU B CD2 1 
ATOM   2947 N N   . LYS B 1 191 ? 4.617   -9.116  -41.880 1.00 16.35 ? 158 LYS B N   1 
ATOM   2948 C CA  . LYS B 1 191 ? 4.054   -8.442  -40.684 1.00 16.17 ? 158 LYS B CA  1 
ATOM   2949 C C   . LYS B 1 191 ? 2.747   -7.731  -41.026 1.00 13.78 ? 158 LYS B C   1 
ATOM   2950 O O   . LYS B 1 191 ? 2.524   -7.371  -42.175 1.00 13.24 ? 158 LYS B O   1 
ATOM   2951 C CB  . LYS B 1 191 ? 4.954   -7.353  -40.142 1.00 17.16 ? 158 LYS B CB  1 
ATOM   2952 C CG  . LYS B 1 191 ? 6.398   -7.729  -39.945 1.00 22.38 ? 158 LYS B CG  1 
ATOM   2953 C CD  . LYS B 1 191 ? 6.681   -8.755  -38.966 1.00 23.74 ? 158 LYS B CD  1 
ATOM   2954 C CE  . LYS B 1 191 ? 8.193   -8.912  -38.762 1.00 23.87 ? 158 LYS B CE  1 
ATOM   2955 N NZ  . LYS B 1 191 ? 8.732   -7.932  -37.795 1.00 25.67 ? 158 LYS B NZ  1 
ATOM   2956 N N   . GLY B 1 192 ? 1.856   -7.666  -40.035 1.00 13.73 ? 159 GLY B N   1 
ATOM   2957 C CA  . GLY B 1 192 ? 0.642   -6.857  -40.110 1.00 14.56 ? 159 GLY B CA  1 
ATOM   2958 C C   . GLY B 1 192 ? 0.440   -6.092  -38.843 1.00 15.27 ? 159 GLY B C   1 
ATOM   2959 O O   . GLY B 1 192 ? 0.740   -6.571  -37.763 1.00 13.07 ? 159 GLY B O   1 
ATOM   2960 N N   . GLU B 1 193 ? -0.011  -4.851  -39.030 1.00 15.41 ? 160 GLU B N   1 
ATOM   2961 C CA  . GLU B 1 193 ? -0.260  -3.886  -37.957 1.00 17.13 ? 160 GLU B CA  1 
ATOM   2962 C C   . GLU B 1 193 ? -1.631  -3.249  -38.178 1.00 16.08 ? 160 GLU B C   1 
ATOM   2963 O O   . GLU B 1 193 ? -1.943  -2.924  -39.320 1.00 15.87 ? 160 GLU B O   1 
ATOM   2964 C CB  . GLU B 1 193 ? 0.849   -2.838  -38.057 1.00 21.83 ? 160 GLU B CB  1 
ATOM   2965 C CG  . GLU B 1 193 ? 0.593   -1.599  -37.254 1.00 29.89 ? 160 GLU B CG  1 
ATOM   2966 C CD  . GLU B 1 193 ? 1.907   -0.879  -37.011 1.00 38.24 ? 160 GLU B CD  1 
ATOM   2967 O OE1 . GLU B 1 193 ? 2.115   -0.427  -35.868 1.00 50.62 ? 160 GLU B OE1 1 
ATOM   2968 O OE2 . GLU B 1 193 ? 2.740   -0.838  -37.956 1.00 44.26 ? 160 GLU B OE2 1 
ATOM   2969 N N   . MET B 1 194 ? -2.440  -3.158  -37.132 1.00 15.70 ? 161 MET B N   1 
ATOM   2970 C CA  . MET B 1 194 ? -3.761  -2.508  -37.210 1.00 15.89 ? 161 MET B CA  1 
ATOM   2971 C C   . MET B 1 194 ? -4.261  -2.132  -35.827 1.00 15.96 ? 161 MET B C   1 
ATOM   2972 O O   . MET B 1 194 ? -3.770  -2.689  -34.836 1.00 16.09 ? 161 MET B O   1 
ATOM   2973 C CB  . MET B 1 194 ? -4.791  -3.430  -37.859 1.00 17.91 ? 161 MET B CB  1 
ATOM   2974 C CG  . MET B 1 194 ? -4.793  -4.834  -37.305 1.00 18.19 ? 161 MET B CG  1 
ATOM   2975 S SD  . MET B 1 194 ? -5.966  -5.903  -38.241 1.00 22.63 ? 161 MET B SD  1 
ATOM   2976 C CE  . MET B 1 194 ? -5.528  -7.481  -37.502 1.00 19.88 ? 161 MET B CE  1 
ATOM   2977 N N   . LYS B 1 195 ? -5.097  -1.088  -35.801 1.00 17.41 ? 162 LYS B N   1 
ATOM   2978 C CA  . LYS B 1 195 ? -5.909  -0.664  -34.635 1.00 16.78 ? 162 LYS B CA  1 
ATOM   2979 C C   . LYS B 1 195 ? -7.283  -1.288  -34.909 1.00 18.07 ? 162 LYS B C   1 
ATOM   2980 O O   . LYS B 1 195 ? -7.895  -1.019  -35.973 1.00 21.65 ? 162 LYS B O   1 
ATOM   2981 C CB  . LYS B 1 195 ? -5.901  0.875   -34.505 1.00 16.92 ? 162 LYS B CB  1 
ATOM   2982 N N   . MET B 1 196 ? -7.694  -2.235  -34.081 1.00 15.50 ? 163 MET B N   1 
ATOM   2983 C CA  . MET B 1 196 ? -8.991  -2.895  -34.201 1.00 15.56 ? 163 MET B CA  1 
ATOM   2984 C C   . MET B 1 196 ? -9.955  -2.244  -33.214 1.00 16.32 ? 163 MET B C   1 
ATOM   2985 O O   . MET B 1 196 ? -9.525  -1.948  -32.081 1.00 18.13 ? 163 MET B O   1 
ATOM   2986 C CB  . MET B 1 196 ? -8.860  -4.395  -33.933 1.00 15.19 ? 163 MET B CB  1 
ATOM   2987 C CG  . MET B 1 196 ? -7.992  -5.092  -34.949 1.00 13.85 ? 163 MET B CG  1 
ATOM   2988 S SD  . MET B 1 196 ? -7.925  -6.902  -34.715 1.00 15.48 ? 163 MET B SD  1 
ATOM   2989 C CE  . MET B 1 196 ? -9.670  -7.294  -34.771 1.00 15.02 ? 163 MET B CE  1 
ATOM   2990 N N   . ARG B 1 197 ? -11.217 -2.074  -33.611 1.00 18.19 ? 164 ARG B N   1 
ATOM   2991 C CA  . ARG B 1 197 ? -12.220 -1.379  -32.748 1.00 18.67 ? 164 ARG B CA  1 
ATOM   2992 C C   . ARG B 1 197 ? -13.385 -2.316  -32.455 1.00 15.21 ? 164 ARG B C   1 
ATOM   2993 O O   . ARG B 1 197 ? -14.064 -2.751  -33.446 1.00 15.71 ? 164 ARG B O   1 
ATOM   2994 C CB  . ARG B 1 197 ? -12.791 -0.128  -33.404 1.00 20.62 ? 164 ARG B CB  1 
ATOM   2995 C CG  . ARG B 1 197 ? -11.775 0.944   -33.775 1.00 23.08 ? 164 ARG B CG  1 
ATOM   2996 C CD  . ARG B 1 197 ? -12.538 2.261   -33.798 1.00 27.52 ? 164 ARG B CD  1 
ATOM   2997 N NE  . ARG B 1 197 ? -12.454 2.869   -32.471 1.00 25.56 ? 164 ARG B NE  1 
ATOM   2998 C CZ  . ARG B 1 197 ? -12.958 4.049   -32.110 1.00 29.36 ? 164 ARG B CZ  1 
ATOM   2999 N NH1 . ARG B 1 197 ? -13.652 4.777   -32.974 1.00 27.00 ? 164 ARG B NH1 1 
ATOM   3000 N NH2 . ARG B 1 197 ? -12.742 4.502   -30.886 1.00 27.21 ? 164 ARG B NH2 1 
ATOM   3001 N N   . LEU B 1 198 ? -13.574 -2.639  -31.173 1.00 14.75 ? 165 LEU B N   1 
ATOM   3002 C CA  . LEU B 1 198 ? -14.710 -3.470  -30.723 1.00 18.01 ? 165 LEU B CA  1 
ATOM   3003 C C   . LEU B 1 198 ? -15.908 -2.566  -30.421 1.00 17.70 ? 165 LEU B C   1 
ATOM   3004 O O   . LEU B 1 198 ? -15.737 -1.617  -29.628 1.00 18.79 ? 165 LEU B O   1 
ATOM   3005 C CB  . LEU B 1 198 ? -14.385 -4.256  -29.457 1.00 21.11 ? 165 LEU B CB  1 
ATOM   3006 C CG  . LEU B 1 198 ? -14.325 -5.761  -29.581 1.00 26.15 ? 165 LEU B CG  1 
ATOM   3007 C CD1 . LEU B 1 198 ? -13.975 -6.389  -28.220 1.00 22.38 ? 165 LEU B CD1 1 
ATOM   3008 C CD2 . LEU B 1 198 ? -15.590 -6.341  -30.240 1.00 22.33 ? 165 LEU B CD2 1 
ATOM   3009 N N   . ARG B 1 199 ? -17.072 -2.839  -30.990 1.00 15.44 ? 166 ARG B N   1 
ATOM   3010 C CA  . ARG B 1 199 ? -18.272 -2.062  -30.577 1.00 16.73 ? 166 ARG B CA  1 
ATOM   3011 C C   . ARG B 1 199 ? -18.612 -2.401  -29.128 1.00 17.21 ? 166 ARG B C   1 
ATOM   3012 O O   . ARG B 1 199 ? -18.518 -3.573  -28.752 1.00 17.22 ? 166 ARG B O   1 
ATOM   3013 C CB  . ARG B 1 199 ? -19.460 -2.330  -31.480 1.00 15.27 ? 166 ARG B CB  1 
ATOM   3014 C CG  . ARG B 1 199 ? -19.186 -1.983  -32.923 1.00 17.74 ? 166 ARG B CG  1 
ATOM   3015 C CD  . ARG B 1 199 ? -20.365 -2.294  -33.789 1.00 19.29 ? 166 ARG B CD  1 
ATOM   3016 N NE  . ARG B 1 199 ? -20.470 -3.747  -34.069 1.00 23.30 ? 166 ARG B NE  1 
ATOM   3017 C CZ  . ARG B 1 199 ? -19.967 -4.365  -35.137 1.00 23.90 ? 166 ARG B CZ  1 
ATOM   3018 N NH1 . ARG B 1 199 ? -19.334 -3.701  -36.074 1.00 26.63 ? 166 ARG B NH1 1 
ATOM   3019 N NH2 . ARG B 1 199 ? -20.166 -5.648  -35.310 1.00 23.35 ? 166 ARG B NH2 1 
ATOM   3020 N N   . LEU B 1 200 ? -19.087 -1.445  -28.365 1.00 17.57 ? 167 LEU B N   1 
ATOM   3021 C CA  . LEU B 1 200 ? -19.644 -1.729  -27.016 1.00 18.36 ? 167 LEU B CA  1 
ATOM   3022 C C   . LEU B 1 200 ? -21.175 -1.688  -27.044 1.00 20.50 ? 167 LEU B C   1 
ATOM   3023 O O   . LEU B 1 200 ? -21.694 -0.849  -27.759 1.00 20.88 ? 167 LEU B O   1 
ATOM   3024 C CB  . LEU B 1 200 ? -19.104 -0.677  -26.067 1.00 20.57 ? 167 LEU B CB  1 
ATOM   3025 C CG  . LEU B 1 200 ? -17.620 -0.779  -25.770 1.00 21.37 ? 167 LEU B CG  1 
ATOM   3026 C CD1 . LEU B 1 200 ? -17.152 0.411   -24.934 1.00 24.16 ? 167 LEU B CD1 1 
ATOM   3027 C CD2 . LEU B 1 200 ? -17.322 -2.107  -25.090 1.00 21.04 ? 167 LEU B CD2 1 
ATOM   3028 N N   . LYS B 1 201 ? -21.830 -2.550  -26.257 1.00 26.96 ? 168 LYS B N   1 
ATOM   3029 C CA  . LYS B 1 201 ? -23.308 -2.572  -25.988 1.00 36.93 ? 168 LYS B CA  1 
ATOM   3030 C C   . LYS B 1 201 ? -23.668 -1.325  -25.183 1.00 42.42 ? 168 LYS B C   1 
ATOM   3031 O O   . LYS B 1 201 ? -23.810 -1.450  -23.950 1.00 72.36 ? 168 LYS B O   1 
ATOM   3032 C CB  . LYS B 1 201 ? -23.749 -3.706  -25.048 1.00 36.05 ? 168 LYS B CB  1 
ATOM   3033 C CG  . LYS B 1 201 ? -23.689 -5.113  -25.600 1.00 43.55 ? 168 LYS B CG  1 
ATOM   3034 C CD  . LYS B 1 201 ? -23.924 -6.217  -24.590 1.00 40.45 ? 168 LYS B CD  1 
ATOM   3035 C CE  . LYS B 1 201 ? -23.161 -7.444  -25.047 1.00 41.59 ? 168 LYS B CE  1 
ATOM   3036 N NZ  . LYS B 1 201 ? -23.989 -8.660  -24.917 1.00 52.61 ? 168 LYS B NZ  1 
ATOM   3037 N N   . ASP B 1 202 ? -23.791 -0.164  -25.791 1.00 42.07 ? 169 ASP B N   1 
ATOM   3038 C CA  . ASP B 1 202 ? -23.523 1.095   -25.040 1.00 39.19 ? 169 ASP B CA  1 
ATOM   3039 C C   . ASP B 1 202 ? -23.320 2.189   -26.074 1.00 36.10 ? 169 ASP B C   1 
ATOM   3040 O O   . ASP B 1 202 ? -23.601 3.351   -25.747 1.00 38.39 ? 169 ASP B O   1 
ATOM   3041 C CB  . ASP B 1 202 ? -22.331 0.910   -24.081 1.00 47.06 ? 169 ASP B CB  1 
ATOM   3042 C CG  . ASP B 1 202 ? -21.238 1.993   -24.012 1.00 44.23 ? 169 ASP B CG  1 
ATOM   3043 O OD1 . ASP B 1 202 ? -20.780 2.461   -25.064 1.00 44.47 ? 169 ASP B OD1 1 
ATOM   3044 O OD2 . ASP B 1 202 ? -20.770 2.284   -22.904 1.00 40.77 ? 169 ASP B OD2 1 
ATOM   3045 N N   . GLY B 1 203 ? -22.815 1.817   -27.249 1.00 29.83 ? 170 GLY B N   1 
ATOM   3046 C CA  . GLY B 1 203 ? -22.669 2.717   -28.408 1.00 30.73 ? 170 GLY B CA  1 
ATOM   3047 C C   . GLY B 1 203 ? -21.233 3.213   -28.600 1.00 29.20 ? 170 GLY B C   1 
ATOM   3048 O O   . GLY B 1 203 ? -20.894 3.664   -29.718 1.00 32.09 ? 170 GLY B O   1 
ATOM   3049 N N   . GLY B 1 204 ? -20.388 3.112   -27.582 1.00 25.46 ? 171 GLY B N   1 
ATOM   3050 C CA  . GLY B 1 204 ? -18.966 3.457   -27.736 1.00 25.58 ? 171 GLY B CA  1 
ATOM   3051 C C   . GLY B 1 204 ? -18.138 2.326   -28.366 1.00 25.96 ? 171 GLY B C   1 
ATOM   3052 O O   . GLY B 1 204 ? -18.706 1.318   -28.874 1.00 23.62 ? 171 GLY B O   1 
ATOM   3053 N N   . HIS B 1 205 ? -16.819 2.480   -28.312 1.00 21.22 ? 172 HIS B N   1 
ATOM   3054 C CA  . HIS B 1 205 ? -15.852 1.498   -28.820 1.00 20.62 ? 172 HIS B CA  1 
ATOM   3055 C C   . HIS B 1 205 ? -14.795 1.203   -27.770 1.00 19.92 ? 172 HIS B C   1 
ATOM   3056 O O   . HIS B 1 205 ? -14.500 2.054   -26.928 1.00 17.85 ? 172 HIS B O   1 
ATOM   3057 C CB  . HIS B 1 205 ? -15.178 1.968   -30.126 1.00 21.89 ? 172 HIS B CB  1 
ATOM   3058 C CG  . HIS B 1 205 ? -16.126 2.112   -31.260 1.00 24.40 ? 172 HIS B CG  1 
ATOM   3059 N ND1 . HIS B 1 205 ? -16.764 3.314   -31.517 1.00 26.41 ? 172 HIS B ND1 1 
ATOM   3060 C CD2 . HIS B 1 205 ? -16.552 1.237   -32.208 1.00 25.17 ? 172 HIS B CD2 1 
ATOM   3061 C CE1 . HIS B 1 205 ? -17.553 3.163   -32.585 1.00 27.75 ? 172 HIS B CE1 1 
ATOM   3062 N NE2 . HIS B 1 205 ? -17.443 1.911   -33.018 1.00 25.38 ? 172 HIS B NE2 1 
ATOM   3063 N N   . TYR B 1 206 ? -14.169 0.030   -27.905 1.00 19.02 ? 173 TYR B N   1 
ATOM   3064 C CA  . TYR B 1 206 ? -13.009 -0.415  -27.097 1.00 17.73 ? 173 TYR B CA  1 
ATOM   3065 C C   . TYR B 1 206 ? -11.913 -0.893  -28.050 1.00 18.76 ? 173 TYR B C   1 
ATOM   3066 O O   . TYR B 1 206 ? -12.223 -1.847  -28.826 1.00 20.34 ? 173 TYR B O   1 
ATOM   3067 C CB  . TYR B 1 206 ? -13.549 -1.532  -26.235 1.00 19.12 ? 173 TYR B CB  1 
ATOM   3068 C CG  . TYR B 1 206 ? -12.585 -2.319  -25.408 1.00 18.95 ? 173 TYR B CG  1 
ATOM   3069 C CD1 . TYR B 1 206 ? -11.853 -1.729  -24.397 1.00 18.52 ? 173 TYR B CD1 1 
ATOM   3070 C CD2 . TYR B 1 206 ? -12.442 -3.679  -25.626 1.00 18.30 ? 173 TYR B CD2 1 
ATOM   3071 C CE1 . TYR B 1 206 ? -10.987 -2.489  -23.632 1.00 18.63 ? 173 TYR B CE1 1 
ATOM   3072 C CE2 . TYR B 1 206 ? -11.606 -4.455  -24.843 1.00 17.21 ? 173 TYR B CE2 1 
ATOM   3073 C CZ  . TYR B 1 206 ? -10.889 -3.854  -23.845 1.00 16.12 ? 173 TYR B CZ  1 
ATOM   3074 O OH  . TYR B 1 206 ? -10.029 -4.573  -23.084 1.00 19.17 ? 173 TYR B OH  1 
ATOM   3075 N N   . ASP B 1 207 ? -10.750 -0.246  -28.025 1.00 18.32 ? 174 ASP B N   1 
ATOM   3076 C CA  . ASP B 1 207 ? -9.716  -0.369  -29.067 1.00 18.63 ? 174 ASP B CA  1 
ATOM   3077 C C   . ASP B 1 207 ? -8.592  -1.302  -28.650 1.00 16.82 ? 174 ASP B C   1 
ATOM   3078 O O   . ASP B 1 207 ? -8.307  -1.446  -27.412 1.00 16.94 ? 174 ASP B O   1 
ATOM   3079 C CB  . ASP B 1 207 ? -9.143  1.008   -29.440 1.00 18.70 ? 174 ASP B CB  1 
ATOM   3080 C CG  . ASP B 1 207 ? -10.188 1.876   -30.099 1.00 22.37 ? 174 ASP B CG  1 
ATOM   3081 O OD1 . ASP B 1 207 ? -11.205 1.307   -30.595 1.00 23.43 ? 174 ASP B OD1 1 
ATOM   3082 O OD2 . ASP B 1 207 ? -10.003 3.098   -30.073 1.00 24.40 ? 174 ASP B OD2 1 
ATOM   3083 N N   . ALA B 1 208 ? -7.965  -1.916  -29.652 1.00 14.45 ? 175 ALA B N   1 
ATOM   3084 C CA  . ALA B 1 208 ? -6.698  -2.667  -29.481 1.00 14.15 ? 175 ALA B CA  1 
ATOM   3085 C C   . ALA B 1 208 ? -5.716  -2.297  -30.561 1.00 14.45 ? 175 ALA B C   1 
ATOM   3086 O O   . ALA B 1 208 ? -6.134  -2.189  -31.712 1.00 17.61 ? 175 ALA B O   1 
ATOM   3087 C CB  . ALA B 1 208 ? -6.935  -4.138  -29.530 1.00 15.31 ? 175 ALA B CB  1 
ATOM   3088 N N   . GLU B 1 209 ? -4.446  -2.162  -30.187 1.00 15.78 ? 176 GLU B N   1 
ATOM   3089 C CA  . GLU B 1 209 ? -3.317  -2.102  -31.147 1.00 17.94 ? 176 GLU B CA  1 
ATOM   3090 C C   . GLU B 1 209 ? -2.910  -3.556  -31.375 1.00 14.49 ? 176 GLU B C   1 
ATOM   3091 O O   . GLU B 1 209 ? -2.638  -4.270  -30.369 1.00 16.36 ? 176 GLU B O   1 
ATOM   3092 C CB  . GLU B 1 209 ? -2.160  -1.239  -30.648 1.00 20.44 ? 176 GLU B CB  1 
ATOM   3093 C CG  . GLU B 1 209 ? -2.509  0.235   -30.459 1.00 24.42 ? 176 GLU B CG  1 
ATOM   3094 C CD  . GLU B 1 209 ? -2.761  0.977   -31.777 1.00 31.86 ? 176 GLU B CD  1 
ATOM   3095 O OE1 . GLU B 1 209 ? -2.449  0.428   -32.869 1.00 31.32 ? 176 GLU B OE1 1 
ATOM   3096 O OE2 . GLU B 1 209 ? -3.257  2.111   -31.714 1.00 39.22 ? 176 GLU B OE2 1 
ATOM   3097 N N   . VAL B 1 210 ? -2.821  -3.989  -32.644 1.00 15.36 ? 177 VAL B N   1 
ATOM   3098 C CA  . VAL B 1 210 ? -2.585  -5.422  -32.957 1.00 14.68 ? 177 VAL B CA  1 
ATOM   3099 C C   . VAL B 1 210 ? -1.345  -5.577  -33.843 1.00 16.33 ? 177 VAL B C   1 
ATOM   3100 O O   . VAL B 1 210 ? -1.254  -4.854  -34.853 1.00 15.78 ? 177 VAL B O   1 
ATOM   3101 C CB  . VAL B 1 210 ? -3.840  -6.018  -33.591 1.00 14.76 ? 177 VAL B CB  1 
ATOM   3102 C CG1 . VAL B 1 210 ? -3.688  -7.492  -33.864 1.00 14.55 ? 177 VAL B CG1 1 
ATOM   3103 C CG2 . VAL B 1 210 ? -5.058  -5.706  -32.716 1.00 14.05 ? 177 VAL B CG2 1 
ATOM   3104 N N   . LYS B 1 211 ? -0.432  -6.490  -33.482 1.00 14.91 ? 178 LYS B N   1 
ATOM   3105 C CA  . LYS B 1 211 ? 0.790   -6.748  -34.269 1.00 14.15 ? 178 LYS B CA  1 
ATOM   3106 C C   . LYS B 1 211 ? 0.834   -8.254  -34.530 1.00 14.07 ? 178 LYS B C   1 
ATOM   3107 O O   . LYS B 1 211 ? 0.674   -9.065  -33.562 1.00 12.50 ? 178 LYS B O   1 
ATOM   3108 C CB  . LYS B 1 211 ? 2.034   -6.235  -33.528 1.00 14.43 ? 178 LYS B CB  1 
ATOM   3109 C CG  . LYS B 1 211 ? 2.135   -4.704  -33.429 1.00 18.72 ? 178 LYS B CG  1 
ATOM   3110 N N   . THR B 1 212 ? 0.985   -8.631  -35.797 1.00 13.10 ? 179 THR B N   1 
ATOM   3111 C CA  . THR B 1 212 ? 1.039   -10.073 -36.143 1.00 13.85 ? 179 THR B CA  1 
ATOM   3112 C C   . THR B 1 212 ? 2.271   -10.324 -37.004 1.00 13.15 ? 179 THR B C   1 
ATOM   3113 O O   . THR B 1 212 ? 2.571   -9.472  -37.856 1.00 12.74 ? 179 THR B O   1 
ATOM   3114 C CB  . THR B 1 212 ? -0.240  -10.544 -36.842 1.00 13.73 ? 179 THR B CB  1 
ATOM   3115 O OG1 . THR B 1 212 ? -1.391  -10.086 -36.127 1.00 14.80 ? 179 THR B OG1 1 
ATOM   3116 C CG2 . THR B 1 212 ? -0.326  -12.043 -36.898 1.00 13.35 ? 179 THR B CG2 1 
ATOM   3117 N N   . THR B 1 213 ? 2.941   -11.453 -36.798 1.00 14.23 ? 180 THR B N   1 
ATOM   3118 C CA  . THR B 1 213 ? 4.039   -11.937 -37.669 1.00 14.88 ? 180 THR B CA  1 
ATOM   3119 C C   . THR B 1 213 ? 3.562   -13.255 -38.277 1.00 14.21 ? 180 THR B C   1 
ATOM   3120 O O   . THR B 1 213 ? 3.091   -14.160 -37.509 1.00 15.67 ? 180 THR B O   1 
ATOM   3121 C CB  . THR B 1 213 ? 5.376   -12.023 -36.937 1.00 15.90 ? 180 THR B CB  1 
ATOM   3122 O OG1 . THR B 1 213 ? 5.681   -10.679 -36.547 1.00 20.94 ? 180 THR B OG1 1 
ATOM   3123 C CG2 . THR B 1 213 ? 6.439   -12.603 -37.828 1.00 17.45 ? 180 THR B CG2 1 
ATOM   3124 N N   . TYR B 1 214 ? 3.592   -13.327 -39.609 1.00 14.14 ? 181 TYR B N   1 
ATOM   3125 C CA  . TYR B 1 214 ? 3.161   -14.521 -40.382 1.00 14.25 ? 181 TYR B CA  1 
ATOM   3126 C C   . TYR B 1 214 ? 4.416   -15.110 -41.031 1.00 15.35 ? 181 TYR B C   1 
ATOM   3127 O O   . TYR B 1 214 ? 5.046   -14.359 -41.832 1.00 16.38 ? 181 TYR B O   1 
ATOM   3128 C CB  . TYR B 1 214 ? 2.116   -14.148 -41.444 1.00 14.52 ? 181 TYR B CB  1 
ATOM   3129 C CG  . TYR B 1 214 ? 0.931   -13.357 -40.945 1.00 14.84 ? 181 TYR B CG  1 
ATOM   3130 C CD1 . TYR B 1 214 ? 0.975   -11.975 -40.908 1.00 14.04 ? 181 TYR B CD1 1 
ATOM   3131 C CD2 . TYR B 1 214 ? -0.258  -13.973 -40.555 1.00 15.97 ? 181 TYR B CD2 1 
ATOM   3132 C CE1 . TYR B 1 214 ? -0.127  -11.220 -40.510 1.00 15.58 ? 181 TYR B CE1 1 
ATOM   3133 C CE2 . TYR B 1 214 ? -1.322  -13.235 -40.106 1.00 14.28 ? 181 TYR B CE2 1 
ATOM   3134 C CZ  . TYR B 1 214 ? -1.267  -11.850 -40.046 1.00 15.72 ? 181 TYR B CZ  1 
ATOM   3135 O OH  . TYR B 1 214 ? -2.345  -11.113 -39.550 1.00 14.40 ? 181 TYR B OH  1 
ATOM   3136 N N   . MET B 1 215 ? 4.759   -16.379 -40.759 1.00 14.01 ? 182 MET B N   1 
ATOM   3137 C CA  A MET B 1 215 ? 6.035   -16.960 -41.259 0.50 14.34 ? 182 MET B CA  1 
ATOM   3138 C CA  B MET B 1 215 ? 6.038   -16.962 -41.255 0.50 15.41 ? 182 MET B CA  1 
ATOM   3139 C C   . MET B 1 215 ? 5.767   -18.283 -41.992 1.00 13.29 ? 182 MET B C   1 
ATOM   3140 O O   . MET B 1 215 ? 5.395   -19.274 -41.344 1.00 14.51 ? 182 MET B O   1 
ATOM   3141 C CB  A MET B 1 215 ? 7.014   -17.171 -40.104 0.50 15.87 ? 182 MET B CB  1 
ATOM   3142 C CB  B MET B 1 215 ? 7.017   -17.167 -40.097 0.50 18.78 ? 182 MET B CB  1 
ATOM   3143 C CG  A MET B 1 215 ? 8.338   -17.699 -40.566 0.50 17.75 ? 182 MET B CG  1 
ATOM   3144 C CG  B MET B 1 215 ? 8.171   -18.072 -40.446 0.50 23.58 ? 182 MET B CG  1 
ATOM   3145 S SD  A MET B 1 215 ? 9.376   -16.486 -41.330 0.50 19.96 ? 182 MET B SD  1 
ATOM   3146 S SD  B MET B 1 215 ? 9.752   -17.448 -39.850 0.50 29.84 ? 182 MET B SD  1 
ATOM   3147 C CE  A MET B 1 215 ? 10.986  -17.236 -41.038 0.50 20.78 ? 182 MET B CE  1 
ATOM   3148 C CE  B MET B 1 215 ? 9.963   -16.156 -41.074 0.50 28.73 ? 182 MET B CE  1 
ATOM   3149 N N   . ALA B 1 216 ? 5.976   -18.273 -43.309 1.00 11.79 ? 183 ALA B N   1 
ATOM   3150 C CA  . ALA B 1 216 ? 5.823   -19.461 -44.133 1.00 12.83 ? 183 ALA B CA  1 
ATOM   3151 C C   . ALA B 1 216 ? 6.882   -20.457 -43.685 1.00 13.68 ? 183 ALA B C   1 
ATOM   3152 O O   . ALA B 1 216 ? 8.012   -20.054 -43.283 1.00 14.89 ? 183 ALA B O   1 
ATOM   3153 C CB  . ALA B 1 216 ? 5.863   -19.123 -45.610 1.00 12.56 ? 183 ALA B CB  1 
ATOM   3154 N N   . LYS B 1 217 ? 6.544   -21.741 -43.728 1.00 13.42 ? 184 LYS B N   1 
ATOM   3155 C CA  . LYS B 1 217 ? 7.473   -22.814 -43.306 1.00 13.63 ? 184 LYS B CA  1 
ATOM   3156 C C   . LYS B 1 217 ? 8.612   -22.946 -44.307 1.00 14.99 ? 184 LYS B C   1 
ATOM   3157 O O   . LYS B 1 217 ? 9.640   -23.542 -43.896 1.00 16.58 ? 184 LYS B O   1 
ATOM   3158 C CB  . LYS B 1 217 ? 6.652   -24.095 -43.141 1.00 13.66 ? 184 LYS B CB  1 
ATOM   3159 C CG  . LYS B 1 217 ? 5.873   -24.094 -41.827 1.00 14.79 ? 184 LYS B CG  1 
ATOM   3160 C CD  . LYS B 1 217 ? 4.662   -24.997 -41.776 1.00 14.93 ? 184 LYS B CD  1 
ATOM   3161 C CE  . LYS B 1 217 ? 3.889   -24.921 -40.482 1.00 14.67 ? 184 LYS B CE  1 
ATOM   3162 N NZ  . LYS B 1 217 ? 2.724   -25.829 -40.470 1.00 16.15 ? 184 LYS B NZ  1 
ATOM   3163 N N   . LYS B 1 218 ? 8.409   -22.495 -45.545 1.00 13.87 ? 185 LYS B N   1 
ATOM   3164 C CA  . LYS B 1 218 ? 9.420   -22.432 -46.620 1.00 15.02 ? 185 LYS B CA  1 
ATOM   3165 C C   . LYS B 1 218 ? 9.473   -20.996 -47.116 1.00 15.10 ? 185 LYS B C   1 
ATOM   3166 O O   . LYS B 1 218 ? 8.472   -20.272 -47.054 1.00 14.23 ? 185 LYS B O   1 
ATOM   3167 C CB  . LYS B 1 218 ? 9.057   -23.425 -47.734 1.00 17.72 ? 185 LYS B CB  1 
ATOM   3168 C CG  . LYS B 1 218 ? 9.368   -24.890 -47.436 1.00 22.46 ? 185 LYS B CG  1 
ATOM   3169 C CD  . LYS B 1 218 ? 10.758  -25.190 -46.895 1.00 25.61 ? 185 LYS B CD  1 
ATOM   3170 C CE  . LYS B 1 218 ? 10.952  -26.648 -46.528 1.00 29.01 ? 185 LYS B CE  1 
ATOM   3171 N NZ  . LYS B 1 218 ? 10.390  -26.971 -45.197 1.00 31.71 ? 185 LYS B NZ  1 
ATOM   3172 N N   . PRO B 1 219 ? 10.644  -20.504 -47.593 1.00 13.50 ? 186 PRO B N   1 
ATOM   3173 C CA  . PRO B 1 219 ? 10.791  -19.106 -48.025 1.00 13.48 ? 186 PRO B CA  1 
ATOM   3174 C C   . PRO B 1 219 ? 10.157  -18.865 -49.409 1.00 12.42 ? 186 PRO B C   1 
ATOM   3175 O O   . PRO B 1 219 ? 10.796  -18.454 -50.397 1.00 12.61 ? 186 PRO B O   1 
ATOM   3176 C CB  . PRO B 1 219 ? 12.293  -18.895 -48.066 1.00 15.01 ? 186 PRO B CB  1 
ATOM   3177 C CG  . PRO B 1 219 ? 12.855  -20.283 -48.380 1.00 14.14 ? 186 PRO B CG  1 
ATOM   3178 C CD  . PRO B 1 219 ? 11.917  -21.223 -47.640 1.00 14.09 ? 186 PRO B CD  1 
ATOM   3179 N N   . VAL B 1 220 ? 8.825   -19.006 -49.420 1.00 11.82 ? 187 VAL B N   1 
ATOM   3180 C CA  . VAL B 1 220 ? 8.023   -18.587 -50.597 1.00 12.76 ? 187 VAL B CA  1 
ATOM   3181 C C   . VAL B 1 220 ? 8.021   -17.056 -50.709 1.00 12.45 ? 187 VAL B C   1 
ATOM   3182 O O   . VAL B 1 220 ? 8.374   -16.366 -49.749 1.00 12.56 ? 187 VAL B O   1 
ATOM   3183 C CB  . VAL B 1 220 ? 6.638   -19.238 -50.581 1.00 13.18 ? 187 VAL B CB  1 
ATOM   3184 C CG1 . VAL B 1 220 ? 6.784   -20.768 -50.619 1.00 15.83 ? 187 VAL B CG1 1 
ATOM   3185 C CG2 . VAL B 1 220 ? 5.819   -18.821 -49.375 1.00 13.40 ? 187 VAL B CG2 1 
ATOM   3186 N N   . GLN B 1 221 ? 7.560   -16.531 -51.843 1.00 13.32 ? 188 GLN B N   1 
ATOM   3187 C CA  . GLN B 1 221 ? 7.826   -15.153 -52.259 1.00 13.60 ? 188 GLN B CA  1 
ATOM   3188 C C   . GLN B 1 221 ? 7.125   -14.203 -51.277 1.00 12.86 ? 188 GLN B C   1 
ATOM   3189 O O   . GLN B 1 221 ? 5.848   -14.158 -51.292 1.00 11.95 ? 188 GLN B O   1 
ATOM   3190 C CB  . GLN B 1 221 ? 7.262   -14.908 -53.658 1.00 13.80 ? 188 GLN B CB  1 
ATOM   3191 C CG  . GLN B 1 221 ? 7.664   -13.546 -54.167 1.00 13.66 ? 188 GLN B CG  1 
ATOM   3192 C CD  . GLN B 1 221 ? 7.192   -13.259 -55.572 1.00 15.71 ? 188 GLN B CD  1 
ATOM   3193 O OE1 . GLN B 1 221 ? 6.401   -14.003 -56.176 1.00 16.51 ? 188 GLN B OE1 1 
ATOM   3194 N NE2 . GLN B 1 221 ? 7.640   -12.117 -56.065 1.00 17.75 ? 188 GLN B NE2 1 
ATOM   3195 N N   . LEU B 1 222 ? 7.868   -13.377 -50.549 1.00 12.04 ? 189 LEU B N   1 
ATOM   3196 C CA  . LEU B 1 222 ? 7.248   -12.253 -49.785 1.00 12.00 ? 189 LEU B CA  1 
ATOM   3197 C C   . LEU B 1 222 ? 6.733   -11.165 -50.707 1.00 13.00 ? 189 LEU B C   1 
ATOM   3198 O O   . LEU B 1 222 ? 7.353   -10.850 -51.724 1.00 14.93 ? 189 LEU B O   1 
ATOM   3199 C CB  . LEU B 1 222 ? 8.277   -11.688 -48.803 1.00 11.45 ? 189 LEU B CB  1 
ATOM   3200 C CG  . LEU B 1 222 ? 8.513   -12.513 -47.541 1.00 12.34 ? 189 LEU B CG  1 
ATOM   3201 C CD1 . LEU B 1 222 ? 9.817   -12.129 -46.883 1.00 13.31 ? 189 LEU B CD1 1 
ATOM   3202 C CD2 . LEU B 1 222 ? 7.349   -12.388 -46.582 1.00 12.73 ? 189 LEU B CD2 1 
ATOM   3203 N N   . PRO B 1 223 ? 5.575   -10.537 -50.358 1.00 12.74 ? 190 PRO B N   1 
ATOM   3204 C CA  . PRO B 1 223 ? 5.056   -9.439  -51.121 1.00 13.83 ? 190 PRO B CA  1 
ATOM   3205 C C   . PRO B 1 223 ? 5.756   -8.146  -50.678 1.00 13.52 ? 190 PRO B C   1 
ATOM   3206 O O   . PRO B 1 223 ? 6.463   -8.131  -49.687 1.00 14.25 ? 190 PRO B O   1 
ATOM   3207 C CB  . PRO B 1 223 ? 3.575   -9.467  -50.716 1.00 15.26 ? 190 PRO B CB  1 
ATOM   3208 C CG  . PRO B 1 223 ? 3.669   -9.741  -49.240 1.00 14.07 ? 190 PRO B CG  1 
ATOM   3209 C CD  . PRO B 1 223 ? 4.767   -10.798 -49.153 1.00 13.63 ? 190 PRO B CD  1 
ATOM   3210 N N   . GLY B 1 224 ? 5.463   -7.067  -51.392 1.00 16.12 ? 191 GLY B N   1 
ATOM   3211 C CA  . GLY B 1 224 ? 5.748   -5.706  -50.938 1.00 15.25 ? 191 GLY B CA  1 
ATOM   3212 C C   . GLY B 1 224 ? 4.670   -5.243  -49.989 1.00 16.74 ? 191 GLY B C   1 
ATOM   3213 O O   . GLY B 1 224 ? 3.729   -6.035  -49.632 1.00 19.65 ? 191 GLY B O   1 
ATOM   3214 N N   . ALA B 1 225 ? 4.736   -3.993  -49.575 1.00 14.71 ? 192 ALA B N   1 
ATOM   3215 C CA  . ALA B 1 225 ? 3.759   -3.436  -48.622 1.00 15.49 ? 192 ALA B CA  1 
ATOM   3216 C C   . ALA B 1 225 ? 2.386   -3.339  -49.304 1.00 15.96 ? 192 ALA B C   1 
ATOM   3217 O O   . ALA B 1 225 ? 2.286   -2.986  -50.499 1.00 16.45 ? 192 ALA B O   1 
ATOM   3218 C CB  . ALA B 1 225 ? 4.267   -2.081  -48.105 1.00 15.86 ? 192 ALA B CB  1 
ATOM   3219 N N   . TYR B 1 226 ? 1.325   -3.651  -48.589 1.00 14.09 ? 193 TYR B N   1 
ATOM   3220 C CA  . TYR B 1 226 ? -0.065  -3.522  -49.101 1.00 14.41 ? 193 TYR B CA  1 
ATOM   3221 C C   . TYR B 1 226 ? -1.060  -3.461  -47.947 1.00 14.94 ? 193 TYR B C   1 
ATOM   3222 O O   . TYR B 1 226 ? -0.624  -3.467  -46.811 1.00 15.91 ? 193 TYR B O   1 
ATOM   3223 C CB  . TYR B 1 226 ? -0.378  -4.647  -50.094 1.00 13.71 ? 193 TYR B CB  1 
ATOM   3224 C CG  . TYR B 1 226 ? -0.554  -6.014  -49.490 1.00 12.54 ? 193 TYR B CG  1 
ATOM   3225 C CD1 . TYR B 1 226 ? 0.543   -6.777  -49.107 1.00 13.34 ? 193 TYR B CD1 1 
ATOM   3226 C CD2 . TYR B 1 226 ? -1.807  -6.582  -49.393 1.00 13.40 ? 193 TYR B CD2 1 
ATOM   3227 C CE1 . TYR B 1 226 ? 0.391   -8.072  -48.622 1.00 12.33 ? 193 TYR B CE1 1 
ATOM   3228 C CE2 . TYR B 1 226 ? -1.981  -7.880  -48.928 1.00 12.88 ? 193 TYR B CE2 1 
ATOM   3229 C CZ  . TYR B 1 226 ? -0.871  -8.638  -48.564 1.00 12.95 ? 193 TYR B CZ  1 
ATOM   3230 O OH  . TYR B 1 226 ? -1.127  -9.900  -48.112 1.00 11.59 ? 193 TYR B OH  1 
ATOM   3231 N N   . LYS B 1 227 ? -2.379  -3.423  -48.215 1.00 13.65 ? 194 LYS B N   1 
ATOM   3232 C CA  . LYS B 1 227 ? -3.377  -3.401  -47.108 1.00 16.91 ? 194 LYS B CA  1 
ATOM   3233 C C   . LYS B 1 227 ? -4.370  -4.519  -47.330 1.00 16.53 ? 194 LYS B C   1 
ATOM   3234 O O   . LYS B 1 227 ? -4.677  -4.851  -48.489 1.00 15.18 ? 194 LYS B O   1 
ATOM   3235 C CB  . LYS B 1 227 ? -4.184  -2.103  -47.045 1.00 19.50 ? 194 LYS B CB  1 
ATOM   3236 C CG  . LYS B 1 227 ? -3.428  -0.822  -46.700 1.00 25.46 ? 194 LYS B CG  1 
ATOM   3237 C CD  . LYS B 1 227 ? -2.989  -0.695  -45.264 1.00 31.77 ? 194 LYS B CD  1 
ATOM   3238 C CE  . LYS B 1 227 ? -2.895  0.750   -44.793 1.00 31.43 ? 194 LYS B CE  1 
ATOM   3239 N NZ  . LYS B 1 227 ? -4.203  1.186   -44.253 1.00 40.71 ? 194 LYS B NZ  1 
ATOM   3240 N N   . THR B 1 228 ? -4.838  -5.097  -46.244 1.00 15.00 ? 195 THR B N   1 
ATOM   3241 C CA  . THR B 1 228 ? -5.961  -6.051  -46.266 1.00 17.01 ? 195 THR B CA  1 
ATOM   3242 C C   . THR B 1 228 ? -7.165  -5.474  -45.522 1.00 17.67 ? 195 THR B C   1 
ATOM   3243 O O   . THR B 1 228 ? -7.021  -5.200  -44.335 1.00 17.20 ? 195 THR B O   1 
ATOM   3244 C CB  . THR B 1 228 ? -5.571  -7.398  -45.664 1.00 18.10 ? 195 THR B CB  1 
ATOM   3245 O OG1 . THR B 1 228 ? -4.463  -7.809  -46.451 1.00 18.94 ? 195 THR B OG1 1 
ATOM   3246 C CG2 . THR B 1 228 ? -6.695  -8.407  -45.793 1.00 18.51 ? 195 THR B CG2 1 
ATOM   3247 N N   . ASP B 1 229 ? -8.297  -5.352  -46.199 1.00 15.53 ? 196 ASP B N   1 
ATOM   3248 C CA  . ASP B 1 229 ? -9.561  -4.932  -45.575 1.00 15.18 ? 196 ASP B CA  1 
ATOM   3249 C C   . ASP B 1 229 ? -10.261 -6.186  -45.088 1.00 15.32 ? 196 ASP B C   1 
ATOM   3250 O O   . ASP B 1 229 ? -10.350 -7.161  -45.845 1.00 14.82 ? 196 ASP B O   1 
ATOM   3251 C CB  . ASP B 1 229 ? -10.436 -4.075  -46.492 1.00 16.79 ? 196 ASP B CB  1 
ATOM   3252 C CG  . ASP B 1 229 ? -9.718  -2.846  -47.004 1.00 18.09 ? 196 ASP B CG  1 
ATOM   3253 O OD1 . ASP B 1 229 ? -9.019  -2.174  -46.203 1.00 22.47 ? 196 ASP B OD1 1 
ATOM   3254 O OD2 . ASP B 1 229 ? -9.765  -2.646  -48.228 1.00 17.59 ? 196 ASP B OD2 1 
ATOM   3255 N N   . ILE B 1 230 ? -10.656 -6.180  -43.821 1.00 13.70 ? 197 ILE B N   1 
ATOM   3256 C CA  . ILE B 1 230 ? -11.209 -7.384  -43.166 1.00 14.14 ? 197 ILE B CA  1 
ATOM   3257 C C   . ILE B 1 230 ? -12.531 -6.997  -42.501 1.00 14.74 ? 197 ILE B C   1 
ATOM   3258 O O   . ILE B 1 230 ? -12.536 -5.999  -41.733 1.00 17.65 ? 197 ILE B O   1 
ATOM   3259 C CB  . ILE B 1 230 ? -10.222 -7.954  -42.148 1.00 15.90 ? 197 ILE B CB  1 
ATOM   3260 C CG1 . ILE B 1 230 ? -8.850  -8.219  -42.774 1.00 16.81 ? 197 ILE B CG1 1 
ATOM   3261 C CG2 . ILE B 1 230 ? -10.774 -9.212  -41.485 1.00 14.35 ? 197 ILE B CG2 1 
ATOM   3262 C CD1 . ILE B 1 230 ? -7.790  -8.385  -41.718 1.00 18.42 ? 197 ILE B CD1 1 
ATOM   3263 N N   . LYS B 1 231 ? -13.574 -7.806  -42.664 1.00 13.76 ? 198 LYS B N   1 
ATOM   3264 C CA  . LYS B 1 231 ? -14.766 -7.644  -41.827 1.00 15.22 ? 198 LYS B CA  1 
ATOM   3265 C C   . LYS B 1 231 ? -15.199 -8.992  -41.300 1.00 13.75 ? 198 LYS B C   1 
ATOM   3266 O O   . LYS B 1 231 ? -15.433 -9.860  -42.105 1.00 13.26 ? 198 LYS B O   1 
ATOM   3267 C CB  . LYS B 1 231 ? -15.822 -6.772  -42.517 1.00 16.97 ? 198 LYS B CB  1 
ATOM   3268 C CG  . LYS B 1 231 ? -17.009 -6.412  -41.620 1.00 17.80 ? 198 LYS B CG  1 
ATOM   3269 C CD  . LYS B 1 231 ? -18.108 -5.703  -42.378 1.00 21.90 ? 198 LYS B CD  1 
ATOM   3270 C CE  . LYS B 1 231 ? -19.047 -4.917  -41.479 1.00 25.90 ? 198 LYS B CE  1 
ATOM   3271 N NZ  . LYS B 1 231 ? -19.461 -5.716  -40.306 1.00 23.82 ? 198 LYS B NZ  1 
ATOM   3272 N N   . LEU B 1 232 ? -15.322 -9.113  -39.956 1.00 14.28 ? 199 LEU B N   1 
ATOM   3273 C CA  . LEU B 1 232 ? -15.659 -10.385 -39.276 1.00 15.50 ? 199 LEU B CA  1 
ATOM   3274 C C   . LEU B 1 232 ? -16.991 -10.203 -38.557 1.00 15.20 ? 199 LEU B C   1 
ATOM   3275 O O   . LEU B 1 232 ? -17.122 -9.207  -37.807 1.00 15.01 ? 199 LEU B O   1 
ATOM   3276 C CB  . LEU B 1 232 ? -14.545 -10.784 -38.302 1.00 17.34 ? 199 LEU B CB  1 
ATOM   3277 C CG  . LEU B 1 232 ? -14.669 -12.157 -37.642 1.00 21.26 ? 199 LEU B CG  1 
ATOM   3278 C CD1 . LEU B 1 232 ? -13.455 -12.383 -36.735 1.00 24.87 ? 199 LEU B CD1 1 
ATOM   3279 C CD2 . LEU B 1 232 ? -15.919 -12.273 -36.799 1.00 25.40 ? 199 LEU B CD2 1 
ATOM   3280 N N   . ASP B 1 233 ? -17.932 -11.101 -38.851 1.00 14.29 ? 200 ASP B N   1 
ATOM   3281 C CA  . ASP B 1 233 ? -19.306 -11.041 -38.310 1.00 15.76 ? 200 ASP B CA  1 
ATOM   3282 C C   . ASP B 1 233 ? -19.585 -12.296 -37.497 1.00 15.19 ? 200 ASP B C   1 
ATOM   3283 O O   . ASP B 1 233 ? -19.325 -13.408 -37.970 1.00 13.02 ? 200 ASP B O   1 
ATOM   3284 C CB  . ASP B 1 233 ? -20.375 -10.869 -39.389 1.00 15.54 ? 200 ASP B CB  1 
ATOM   3285 C CG  . ASP B 1 233 ? -20.207 -9.654  -40.255 1.00 16.87 ? 200 ASP B CG  1 
ATOM   3286 O OD1 . ASP B 1 233 ? -19.841 -8.619  -39.701 1.00 17.84 ? 200 ASP B OD1 1 
ATOM   3287 O OD2 . ASP B 1 233 ? -20.340 -9.781  -41.492 1.00 18.35 ? 200 ASP B OD2 1 
ATOM   3288 N N   . ILE B 1 234 ? -20.152 -12.122 -36.311 1.00 14.82 ? 201 ILE B N   1 
ATOM   3289 C CA  . ILE B 1 234 ? -20.793 -13.250 -35.601 1.00 15.14 ? 201 ILE B CA  1 
ATOM   3290 C C   . ILE B 1 234 ? -22.208 -13.398 -36.172 1.00 14.95 ? 201 ILE B C   1 
ATOM   3291 O O   . ILE B 1 234 ? -22.974 -12.403 -36.088 1.00 15.05 ? 201 ILE B O   1 
ATOM   3292 C CB  . ILE B 1 234 ? -20.813 -12.978 -34.095 1.00 15.52 ? 201 ILE B CB  1 
ATOM   3293 C CG1 . ILE B 1 234 ? -19.403 -12.713 -33.580 1.00 14.81 ? 201 ILE B CG1 1 
ATOM   3294 C CG2 . ILE B 1 234 ? -21.486 -14.137 -33.408 1.00 14.32 ? 201 ILE B CG2 1 
ATOM   3295 C CD1 . ILE B 1 234 ? -18.409 -13.838 -33.836 1.00 16.70 ? 201 ILE B CD1 1 
ATOM   3296 N N   . THR B 1 235 ? -22.498 -14.531 -36.823 1.00 14.41 ? 202 THR B N   1 
ATOM   3297 C CA  . THR B 1 235 ? -23.754 -14.703 -37.575 1.00 14.04 ? 202 THR B CA  1 
ATOM   3298 C C   . THR B 1 235 ? -24.783 -15.484 -36.777 1.00 15.74 ? 202 THR B C   1 
ATOM   3299 O O   . THR B 1 235 ? -25.995 -15.371 -37.071 1.00 13.25 ? 202 THR B O   1 
ATOM   3300 C CB  . THR B 1 235 ? -23.468 -15.361 -38.928 1.00 13.78 ? 202 THR B CB  1 
ATOM   3301 O OG1 . THR B 1 235 ? -22.895 -16.634 -38.641 1.00 13.99 ? 202 THR B OG1 1 
ATOM   3302 C CG2 . THR B 1 235 ? -22.531 -14.553 -39.795 1.00 14.69 ? 202 THR B CG2 1 
ATOM   3303 N N   . SER B 1 236 ? -24.334 -16.294 -35.823 1.00 17.07 ? 203 SER B N   1 
ATOM   3304 C CA  . SER B 1 236 ? -25.187 -17.106 -34.928 1.00 19.56 ? 203 SER B CA  1 
ATOM   3305 C C   . SER B 1 236 ? -24.466 -17.283 -33.591 1.00 18.53 ? 203 SER B C   1 
ATOM   3306 O O   . SER B 1 236 ? -23.253 -17.475 -33.597 1.00 15.76 ? 203 SER B O   1 
ATOM   3307 C CB  . SER B 1 236 ? -25.501 -18.464 -35.514 1.00 19.73 ? 203 SER B CB  1 
ATOM   3308 O OG  . SER B 1 236 ? -26.555 -19.063 -34.780 1.00 25.12 ? 203 SER B OG  1 
ATOM   3309 N N   . HIS B 1 237 ? -25.209 -17.330 -32.493 1.00 19.21 ? 204 HIS B N   1 
ATOM   3310 C CA  . HIS B 1 237 ? -24.645 -17.794 -31.206 1.00 17.90 ? 204 HIS B CA  1 
ATOM   3311 C C   . HIS B 1 237 ? -25.811 -18.232 -30.342 1.00 20.86 ? 204 HIS B C   1 
ATOM   3312 O O   . HIS B 1 237 ? -26.887 -17.603 -30.474 1.00 18.72 ? 204 HIS B O   1 
ATOM   3313 C CB  . HIS B 1 237 ? -23.844 -16.702 -30.490 1.00 19.22 ? 204 HIS B CB  1 
ATOM   3314 C CG  . HIS B 1 237 ? -24.597 -15.450 -30.207 1.00 19.44 ? 204 HIS B CG  1 
ATOM   3315 N ND1 . HIS B 1 237 ? -25.231 -15.225 -28.972 1.00 18.10 ? 204 HIS B ND1 1 
ATOM   3316 C CD2 . HIS B 1 237 ? -24.832 -14.375 -30.965 1.00 19.14 ? 204 HIS B CD2 1 
ATOM   3317 C CE1 . HIS B 1 237 ? -25.848 -14.085 -29.012 1.00 19.99 ? 204 HIS B CE1 1 
ATOM   3318 N NE2 . HIS B 1 237 ? -25.640 -13.536 -30.244 1.00 21.25 ? 204 HIS B NE2 1 
ATOM   3319 N N   . ASN B 1 238 ? -25.546 -19.167 -29.439 1.00 21.24 ? 205 ASN B N   1 
ATOM   3320 C CA  . ASN B 1 238 ? -26.425 -19.389 -28.252 1.00 24.32 ? 205 ASN B CA  1 
ATOM   3321 C C   . ASN B 1 238 ? -26.161 -18.316 -27.176 1.00 22.49 ? 205 ASN B C   1 
ATOM   3322 O O   . ASN B 1 238 ? -25.215 -17.477 -27.310 1.00 21.74 ? 205 ASN B O   1 
ATOM   3323 C CB  . ASN B 1 238 ? -26.373 -20.838 -27.780 1.00 19.31 ? 205 ASN B CB  1 
ATOM   3324 C CG  . ASN B 1 238 ? -25.038 -21.286 -27.205 1.00 21.37 ? 205 ASN B CG  1 
ATOM   3325 O OD1 . ASN B 1 238 ? -24.098 -20.505 -27.097 1.00 21.99 ? 205 ASN B OD1 1 
ATOM   3326 N ND2 . ASN B 1 238 ? -24.924 -22.569 -26.880 1.00 21.20 ? 205 ASN B ND2 1 
ATOM   3327 N N   . GLU B 1 239 ? -27.033 -18.265 -26.155 1.00 27.21 ? 206 GLU B N   1 
ATOM   3328 C CA  . GLU B 1 239 ? -27.008 -17.163 -25.152 1.00 26.59 ? 206 GLU B CA  1 
ATOM   3329 C C   . GLU B 1 239 ? -25.614 -17.062 -24.511 1.00 23.23 ? 206 GLU B C   1 
ATOM   3330 O O   . GLU B 1 239 ? -25.163 -15.940 -24.328 1.00 23.19 ? 206 GLU B O   1 
ATOM   3331 C CB  . GLU B 1 239 ? -28.000 -17.401 -24.004 1.00 31.52 ? 206 GLU B CB  1 
ATOM   3332 C CG  . GLU B 1 239 ? -28.261 -16.144 -23.159 1.00 36.43 ? 206 GLU B CG  1 
ATOM   3333 C CD  . GLU B 1 239 ? -29.655 -16.094 -22.496 1.00 44.18 ? 206 GLU B CD  1 
ATOM   3334 O OE1 . GLU B 1 239 ? -30.612 -15.561 -23.125 1.00 54.09 ? 206 GLU B OE1 1 
ATOM   3335 O OE2 . GLU B 1 239 ? -29.807 -16.622 -21.352 1.00 50.72 ? 206 GLU B OE2 1 
ATOM   3336 N N   . ASP B 1 240 ? -25.009 -18.201 -24.161 1.00 20.43 ? 207 ASP B N   1 
ATOM   3337 C CA  . ASP B 1 240 ? -23.756 -18.223 -23.361 1.00 23.49 ? 207 ASP B CA  1 
ATOM   3338 C C   . ASP B 1 240 ? -22.533 -18.470 -24.265 1.00 22.37 ? 207 ASP B C   1 
ATOM   3339 O O   . ASP B 1 240 ? -21.438 -18.669 -23.720 1.00 20.81 ? 207 ASP B O   1 
ATOM   3340 C CB  . ASP B 1 240 ? -23.879 -19.274 -22.280 1.00 25.25 ? 207 ASP B CB  1 
ATOM   3341 C CG  . ASP B 1 240 ? -23.749 -20.699 -22.752 1.00 25.51 ? 207 ASP B CG  1 
ATOM   3342 O OD1 . ASP B 1 240 ? -23.699 -20.972 -23.980 1.00 28.81 ? 207 ASP B OD1 1 
ATOM   3343 O OD2 . ASP B 1 240 ? -23.766 -21.550 -21.874 1.00 27.85 ? 207 ASP B OD2 1 
ATOM   3344 N N   . TYR B 1 241 ? -22.710 -18.386 -25.595 1.00 20.25 ? 208 TYR B N   1 
ATOM   3345 C CA  . TYR B 1 241 ? -21.617 -18.421 -26.605 1.00 18.89 ? 208 TYR B CA  1 
ATOM   3346 C C   . TYR B 1 241 ? -20.748 -19.668 -26.497 1.00 18.63 ? 208 TYR B C   1 
ATOM   3347 O O   . TYR B 1 241 ? -19.529 -19.575 -26.769 1.00 17.38 ? 208 TYR B O   1 
ATOM   3348 C CB  . TYR B 1 241 ? -20.729 -17.179 -26.520 1.00 19.32 ? 208 TYR B CB  1 
ATOM   3349 C CG  . TYR B 1 241 ? -21.367 -15.939 -27.048 1.00 17.38 ? 208 TYR B CG  1 
ATOM   3350 C CD1 . TYR B 1 241 ? -22.288 -15.249 -26.268 1.00 19.89 ? 208 TYR B CD1 1 
ATOM   3351 C CD2 . TYR B 1 241 ? -21.027 -15.412 -28.276 1.00 18.56 ? 208 TYR B CD2 1 
ATOM   3352 C CE1 . TYR B 1 241 ? -22.873 -14.078 -26.697 1.00 19.15 ? 208 TYR B CE1 1 
ATOM   3353 C CE2 . TYR B 1 241 ? -21.583 -14.226 -28.703 1.00 19.72 ? 208 TYR B CE2 1 
ATOM   3354 C CZ  . TYR B 1 241 ? -22.525 -13.566 -27.916 1.00 18.20 ? 208 TYR B CZ  1 
ATOM   3355 O OH  . TYR B 1 241 ? -23.107 -12.402 -28.332 1.00 20.26 ? 208 TYR B OH  1 
ATOM   3356 N N   . THR B 1 242 ? -21.351 -20.818 -26.163 1.00 17.12 ? 209 THR B N   1 
ATOM   3357 C CA  . THR B 1 242 ? -20.744 -22.165 -26.233 1.00 15.97 ? 209 THR B CA  1 
ATOM   3358 C C   . THR B 1 242 ? -20.881 -22.707 -27.650 1.00 15.71 ? 209 THR B C   1 
ATOM   3359 O O   . THR B 1 242 ? -20.169 -23.641 -27.941 1.00 16.21 ? 209 THR B O   1 
ATOM   3360 C CB  . THR B 1 242 ? -21.302 -23.110 -25.172 1.00 19.84 ? 209 THR B CB  1 
ATOM   3361 O OG1 . THR B 1 242 ? -22.732 -23.075 -25.141 1.00 19.23 ? 209 THR B OG1 1 
ATOM   3362 C CG2 . THR B 1 242 ? -20.774 -22.735 -23.807 1.00 19.44 ? 209 THR B CG2 1 
ATOM   3363 N N   . ILE B 1 243 ? -21.762 -22.127 -28.468 1.00 15.64 ? 210 ILE B N   1 
ATOM   3364 C CA  . ILE B 1 243 ? -22.003 -22.554 -29.872 1.00 15.71 ? 210 ILE B CA  1 
ATOM   3365 C C   . ILE B 1 243 ? -22.082 -21.276 -30.678 1.00 14.41 ? 210 ILE B C   1 
ATOM   3366 O O   . ILE B 1 243 ? -22.892 -20.423 -30.359 1.00 17.15 ? 210 ILE B O   1 
ATOM   3367 C CB  . ILE B 1 243 ? -23.246 -23.442 -30.013 1.00 19.18 ? 210 ILE B CB  1 
ATOM   3368 C CG1 . ILE B 1 243 ? -23.230 -24.683 -29.131 1.00 21.57 ? 210 ILE B CG1 1 
ATOM   3369 C CG2 . ILE B 1 243 ? -23.449 -23.816 -31.491 1.00 17.06 ? 210 ILE B CG2 1 
ATOM   3370 C CD1 . ILE B 1 243 ? -24.629 -25.354 -29.016 1.00 23.41 ? 210 ILE B CD1 1 
ATOM   3371 N N   . VAL B 1 244 ? -21.198 -21.094 -31.663 1.00 13.42 ? 211 VAL B N   1 
ATOM   3372 C CA  . VAL B 1 244 ? -21.024 -19.787 -32.338 1.00 14.12 ? 211 VAL B CA  1 
ATOM   3373 C C   . VAL B 1 244 ? -20.747 -20.065 -33.825 1.00 14.78 ? 211 VAL B C   1 
ATOM   3374 O O   . VAL B 1 244 ? -20.046 -21.046 -34.156 1.00 15.28 ? 211 VAL B O   1 
ATOM   3375 C CB  . VAL B 1 244 ? -19.917 -18.939 -31.672 1.00 14.99 ? 211 VAL B CB  1 
ATOM   3376 C CG1 . VAL B 1 244 ? -19.814 -17.549 -32.256 1.00 15.49 ? 211 VAL B CG1 1 
ATOM   3377 C CG2 . VAL B 1 244 ? -20.100 -18.837 -30.182 1.00 15.70 ? 211 VAL B CG2 1 
ATOM   3378 N N   . GLU B 1 245 ? -21.229 -19.191 -34.689 1.00 14.24 ? 212 GLU B N   1 
ATOM   3379 C CA  . GLU B 1 245 ? -20.834 -19.223 -36.114 1.00 14.18 ? 212 GLU B CA  1 
ATOM   3380 C C   . GLU B 1 245 ? -20.314 -17.840 -36.509 1.00 14.31 ? 212 GLU B C   1 
ATOM   3381 O O   . GLU B 1 245 ? -20.845 -16.830 -36.033 1.00 13.59 ? 212 GLU B O   1 
ATOM   3382 C CB  . GLU B 1 245 ? -22.038 -19.600 -36.986 1.00 15.69 ? 212 GLU B CB  1 
ATOM   3383 C CG  . GLU B 1 245 ? -22.691 -20.877 -36.542 1.00 15.23 ? 212 GLU B CG  1 
ATOM   3384 C CD  . GLU B 1 245 ? -23.738 -21.387 -37.515 1.00 16.45 ? 212 GLU B CD  1 
ATOM   3385 O OE1 . GLU B 1 245 ? -23.783 -20.889 -38.679 1.00 16.72 ? 212 GLU B OE1 1 
ATOM   3386 O OE2 . GLU B 1 245 ? -24.539 -22.268 -37.082 1.00 16.13 ? 212 GLU B OE2 1 
ATOM   3387 N N   . GLN B 1 246 ? -19.342 -17.801 -37.399 1.00 13.48 ? 213 GLN B N   1 
ATOM   3388 C CA  . GLN B 1 246 ? -18.675 -16.564 -37.834 1.00 15.69 ? 213 GLN B CA  1 
ATOM   3389 C C   . GLN B 1 246 ? -18.538 -16.565 -39.349 1.00 14.02 ? 213 GLN B C   1 
ATOM   3390 O O   . GLN B 1 246 ? -18.341 -17.585 -39.892 1.00 13.29 ? 213 GLN B O   1 
ATOM   3391 C CB  . GLN B 1 246 ? -17.210 -16.453 -37.383 1.00 16.31 ? 213 GLN B CB  1 
ATOM   3392 C CG  . GLN B 1 246 ? -16.971 -16.923 -36.005 1.00 17.92 ? 213 GLN B CG  1 
ATOM   3393 C CD  . GLN B 1 246 ? -15.679 -16.515 -35.345 1.00 15.29 ? 213 GLN B CD  1 
ATOM   3394 O OE1 . GLN B 1 246 ? -15.646 -16.505 -34.130 1.00 15.52 ? 213 GLN B OE1 1 
ATOM   3395 N NE2 . GLN B 1 246 ? -14.603 -16.295 -36.098 1.00 14.65 ? 213 GLN B NE2 1 
ATOM   3396 N N   . TYR B 1 247 ? -18.585 -15.372 -39.938 1.00 14.30 ? 214 TYR B N   1 
ATOM   3397 C CA  . TYR B 1 247 ? -18.263 -15.108 -41.354 1.00 14.90 ? 214 TYR B CA  1 
ATOM   3398 C C   . TYR B 1 247 ? -17.144 -14.080 -41.391 1.00 14.49 ? 214 TYR B C   1 
ATOM   3399 O O   . TYR B 1 247 ? -17.131 -13.125 -40.575 1.00 15.91 ? 214 TYR B O   1 
ATOM   3400 C CB  . TYR B 1 247 ? -19.505 -14.570 -42.081 1.00 14.19 ? 214 TYR B CB  1 
ATOM   3401 C CG  . TYR B 1 247 ? -19.234 -14.055 -43.463 1.00 15.83 ? 214 TYR B CG  1 
ATOM   3402 C CD1 . TYR B 1 247 ? -18.942 -14.881 -44.544 1.00 14.94 ? 214 TYR B CD1 1 
ATOM   3403 C CD2 . TYR B 1 247 ? -19.212 -12.682 -43.683 1.00 16.12 ? 214 TYR B CD2 1 
ATOM   3404 C CE1 . TYR B 1 247 ? -18.769 -14.350 -45.812 1.00 15.81 ? 214 TYR B CE1 1 
ATOM   3405 C CE2 . TYR B 1 247 ? -18.985 -12.148 -44.931 1.00 16.22 ? 214 TYR B CE2 1 
ATOM   3406 C CZ  . TYR B 1 247 ? -18.731 -12.976 -45.996 1.00 18.27 ? 214 TYR B CZ  1 
ATOM   3407 O OH  . TYR B 1 247 ? -18.511 -12.349 -47.201 1.00 20.17 ? 214 TYR B OH  1 
ATOM   3408 N N   . GLU B 1 248 ? -16.216 -14.238 -42.325 1.00 13.08 ? 215 GLU B N   1 
ATOM   3409 C CA  . GLU B 1 248 ? -15.200 -13.203 -42.553 1.00 13.91 ? 215 GLU B CA  1 
ATOM   3410 C C   . GLU B 1 248 ? -14.982 -13.016 -44.050 1.00 13.21 ? 215 GLU B C   1 
ATOM   3411 O O   . GLU B 1 248 ? -14.895 -14.035 -44.792 1.00 13.33 ? 215 GLU B O   1 
ATOM   3412 C CB  . GLU B 1 248 ? -13.898 -13.579 -41.856 1.00 14.35 ? 215 GLU B CB  1 
ATOM   3413 C CG  . GLU B 1 248 ? -12.857 -12.465 -41.947 1.00 16.26 ? 215 GLU B CG  1 
ATOM   3414 C CD  . GLU B 1 248 ? -11.652 -12.809 -41.109 1.00 16.12 ? 215 GLU B CD  1 
ATOM   3415 O OE1 . GLU B 1 248 ? -11.776 -12.931 -39.836 1.00 19.08 ? 215 GLU B OE1 1 
ATOM   3416 O OE2 . GLU B 1 248 ? -10.544 -12.825 -41.704 1.00 17.04 ? 215 GLU B OE2 1 
ATOM   3417 N N   . ARG B 1 249 ? -14.863 -11.766 -44.455 1.00 13.39 ? 216 ARG B N   1 
ATOM   3418 C CA  . ARG B 1 249 ? -14.458 -11.331 -45.801 1.00 13.77 ? 216 ARG B CA  1 
ATOM   3419 C C   . ARG B 1 249 ? -13.157 -10.563 -45.670 1.00 12.32 ? 216 ARG B C   1 
ATOM   3420 O O   . ARG B 1 249 ? -13.074 -9.652  -44.793 1.00 14.86 ? 216 ARG B O   1 
ATOM   3421 C CB  . ARG B 1 249 ? -15.541 -10.468 -46.443 1.00 16.11 ? 216 ARG B CB  1 
ATOM   3422 C CG  . ARG B 1 249 ? -15.201 -9.938  -47.829 1.00 22.98 ? 216 ARG B CG  1 
ATOM   3423 C CD  . ARG B 1 249 ? -16.336 -9.368  -48.673 1.00 25.76 ? 216 ARG B CD  1 
ATOM   3424 N NE  . ARG B 1 249 ? -16.014 -9.478  -50.094 1.00 30.09 ? 216 ARG B NE  1 
ATOM   3425 N N   . ALA B 1 250 ? -12.180 -10.870 -46.520 1.00 12.98 ? 217 ALA B N   1 
ATOM   3426 C CA  . ALA B 1 250 ? -10.866 -10.217 -46.457 1.00 15.62 ? 217 ALA B CA  1 
ATOM   3427 C C   . ALA B 1 250 ? -10.348 -10.055 -47.864 1.00 15.25 ? 217 ALA B C   1 
ATOM   3428 O O   . ALA B 1 250 ? -10.398 -11.035 -48.637 1.00 14.41 ? 217 ALA B O   1 
ATOM   3429 C CB  . ALA B 1 250 ? -9.912  -10.976 -45.601 1.00 16.92 ? 217 ALA B CB  1 
ATOM   3430 N N   . GLU B 1 251 ? -9.829  -8.880  -48.158 1.00 15.16 ? 218 GLU B N   1 
ATOM   3431 C CA  . GLU B 1 251 ? -9.360  -8.572  -49.529 1.00 15.19 ? 218 GLU B CA  1 
ATOM   3432 C C   . GLU B 1 251 ? -8.126  -7.681  -49.489 1.00 15.65 ? 218 GLU B C   1 
ATOM   3433 O O   . GLU B 1 251 ? -8.136  -6.617  -48.810 1.00 13.41 ? 218 GLU B O   1 
ATOM   3434 C CB  . GLU B 1 251 ? -10.457 -7.923  -50.359 1.00 15.40 ? 218 GLU B CB  1 
ATOM   3435 C CG  . GLU B 1 251 ? -9.999  -7.704  -51.789 1.00 20.33 ? 218 GLU B CG  1 
ATOM   3436 C CD  . GLU B 1 251 ? -11.084 -7.419  -52.822 1.00 21.35 ? 218 GLU B CD  1 
ATOM   3437 O OE1 . GLU B 1 251 ? -10.712 -7.199  -54.015 1.00 24.12 ? 218 GLU B OE1 1 
ATOM   3438 O OE2 . GLU B 1 251 ? -12.277 -7.456  -52.457 1.00 24.03 ? 218 GLU B OE2 1 
ATOM   3439 N N   . GLY B 1 252 ? -7.082  -8.121  -50.164 1.00 15.40 ? 219 GLY B N   1 
ATOM   3440 C CA  . GLY B 1 252 ? -5.830  -7.349  -50.254 1.00 15.84 ? 219 GLY B CA  1 
ATOM   3441 C C   . GLY B 1 252 ? -5.917  -6.305  -51.377 1.00 17.55 ? 219 GLY B C   1 
ATOM   3442 O O   . GLY B 1 252 ? -6.458  -6.614  -52.467 1.00 18.04 ? 219 GLY B O   1 
ATOM   3443 N N   . ARG B 1 253 ? -5.315  -5.129  -51.169 1.00 16.92 ? 220 ARG B N   1 
ATOM   3444 C CA  . ARG B 1 253 ? -5.214  -4.090  -52.220 1.00 17.08 ? 220 ARG B CA  1 
ATOM   3445 C C   . ARG B 1 253 ? -3.929  -3.297  -52.044 1.00 18.00 ? 220 ARG B C   1 
ATOM   3446 O O   . ARG B 1 253 ? -3.360  -3.305  -50.967 1.00 16.64 ? 220 ARG B O   1 
ATOM   3447 C CB  . ARG B 1 253 ? -6.399  -3.133  -52.145 1.00 18.49 ? 220 ARG B CB  1 
ATOM   3448 C CG  . ARG B 1 253 ? -6.531  -2.486  -50.774 1.00 18.83 ? 220 ARG B CG  1 
ATOM   3449 C CD  . ARG B 1 253 ? -7.430  -1.274  -50.766 1.00 24.08 ? 220 ARG B CD  1 
ATOM   3450 N NE  . ARG B 1 253 ? -7.682  -0.979  -49.351 1.00 21.11 ? 220 ARG B NE  1 
ATOM   3451 C CZ  . ARG B 1 253 ? -6.994  -0.123  -48.603 1.00 23.68 ? 220 ARG B CZ  1 
ATOM   3452 N NH1 . ARG B 1 253 ? -5.986  0.569   -49.108 1.00 25.83 ? 220 ARG B NH1 1 
ATOM   3453 N NH2 . ARG B 1 253 ? -7.325  0.040   -47.333 1.00 27.11 ? 220 ARG B NH2 1 
ATOM   3454 N N   . HIS B 1 254 ? -3.488  -2.598  -53.080 1.00 20.94 ? 221 HIS B N   1 
ATOM   3455 C CA  . HIS B 1 254 ? -2.330  -1.653  -52.965 1.00 23.69 ? 221 HIS B CA  1 
ATOM   3456 C C   . HIS B 1 254 ? -2.674  -0.509  -52.001 1.00 26.50 ? 221 HIS B C   1 
ATOM   3457 O O   . HIS B 1 254 ? -3.867  -0.155  -51.863 1.00 27.77 ? 221 HIS B O   1 
ATOM   3458 C CB  . HIS B 1 254 ? -1.888  -1.147  -54.331 1.00 23.94 ? 221 HIS B CB  1 
ATOM   3459 C CG  . HIS B 1 254 ? -1.306  -2.231  -55.163 1.00 25.91 ? 221 HIS B CG  1 
ATOM   3460 N ND1 . HIS B 1 254 ? -0.040  -2.751  -54.912 1.00 26.15 ? 221 HIS B ND1 1 
ATOM   3461 C CD2 . HIS B 1 254 ? -1.788  -2.890  -56.238 1.00 26.80 ? 221 HIS B CD2 1 
ATOM   3462 C CE1 . HIS B 1 254 ? 0.203   -3.703  -55.795 1.00 24.85 ? 221 HIS B CE1 1 
ATOM   3463 N NE2 . HIS B 1 254 ? -0.851  -3.800  -56.616 1.00 25.65 ? 221 HIS B NE2 1 
ATOM   3464 N N   . SER B 1 255 ? -1.695  -0.077  -51.215 1.00 29.85 ? 222 SER B N   1 
ATOM   3465 C CA  . SER B 1 255 ? -1.928  0.843   -50.075 1.00 42.06 ? 222 SER B CA  1 
ATOM   3466 C C   . SER B 1 255 ? -1.785  2.292   -50.572 1.00 53.17 ? 222 SER B C   1 
ATOM   3467 O O   . SER B 1 255 ? -0.661  2.629   -51.003 1.00 62.76 ? 222 SER B O   1 
ATOM   3468 C CB  . SER B 1 255 ? -0.986  0.522   -48.940 1.00 38.80 ? 222 SER B CB  1 
ATOM   3469 O OG  . SER B 1 255 ? 0.342   0.795   -49.328 1.00 43.14 ? 222 SER B OG  1 
ATOM   3470 N N   . THR B 1 256 ? -2.906  3.043   -50.589 1.00 68.35 ? 223 THR B N   1 
ATOM   3471 C CA  . THR B 1 256 ? -3.056  4.531   -50.655 1.00 74.07 ? 223 THR B CA  1 
ATOM   3472 C C   . THR B 1 256 ? -1.910  5.185   -51.419 1.00 77.89 ? 223 THR B C   1 
ATOM   3473 O O   . THR B 1 256 ? -1.819  4.983   -52.623 1.00 77.53 ? 223 THR B O   1 
ATOM   3474 N N   . GLY B 1 257 ? -1.098  6.030   -50.757 1.00 85.33 ? 224 GLY B N   1 
ATOM   3475 C CA  . GLY B 1 257 ? -1.427  6.744   -49.525 1.00 85.67 ? 224 GLY B CA  1 
ATOM   3476 C C   . GLY B 1 257 ? -1.142  5.964   -48.248 1.00 83.52 ? 224 GLY B C   1 
ATOM   3477 O O   . GLY B 1 257 ? 0.038   5.876   -47.824 1.00 71.59 ? 224 GLY B O   1 
ATOM   3478 N N   . ALA B 1 258 ? -2.220  5.526   -47.597 1.00 89.54 ? 225 ALA B N   1 
ATOM   3479 C CA  . ALA B 1 258 ? -2.296  4.297   -46.770 1.00 86.54 ? 225 ALA B CA  1 
ATOM   3480 C C   . ALA B 1 258 ? -3.700  3.682   -46.952 1.00 69.51 ? 225 ALA B C   1 
ATOM   3481 O O   . ALA B 1 258 ? -4.491  3.724   -46.033 1.00 84.41 ? 225 ALA B O   1 
ATOM   3482 C CB  . ALA B 1 258 ? -1.963  4.596   -45.318 1.00 83.55 ? 225 ALA B CB  1 
ATOM   3483 O OXT . ALA B 1 258 ? -4.136  3.127   -47.981 1.00 42.28 ? 225 ALA B OXT 1 
HETATM 3484 O O   . HOH C 2 .   ? -2.053  -24.517 -13.598 1.00 39.36 ? 301 HOH A O   1 
HETATM 3485 O O   . HOH C 2 .   ? -4.118  -16.312 -19.362 1.00 36.33 ? 302 HOH A O   1 
HETATM 3486 O O   A HOH C 2 .   ? -3.567  -18.494 -16.161 0.50 13.80 ? 303 HOH A O   1 
HETATM 3487 O O   B HOH C 2 .   ? -3.886  -20.681 -17.065 0.50 23.70 ? 303 HOH A O   1 
HETATM 3488 O O   . HOH C 2 .   ? 11.866  -4.588  1.456   1.00 29.53 ? 304 HOH A O   1 
HETATM 3489 O O   . HOH C 2 .   ? 16.577  -32.634 -4.566  1.00 31.31 ? 305 HOH A O   1 
HETATM 3490 O O   . HOH C 2 .   ? 13.515  -24.273 -31.086 1.00 24.85 ? 306 HOH A O   1 
HETATM 3491 O O   . HOH C 2 .   ? 17.681  -28.139 -5.453  1.00 26.38 ? 307 HOH A O   1 
HETATM 3492 O O   . HOH C 2 .   ? 26.057  -23.685 -13.720 1.00 21.23 ? 308 HOH A O   1 
HETATM 3493 O O   . HOH C 2 .   ? 15.741  -8.011  1.822   1.00 36.66 ? 309 HOH A O   1 
HETATM 3494 O O   . HOH C 2 .   ? 27.197  -25.082 -10.330 1.00 22.36 ? 310 HOH A O   1 
HETATM 3495 O O   . HOH C 2 .   ? 22.079  -17.528 -25.772 1.00 30.38 ? 311 HOH A O   1 
HETATM 3496 O O   . HOH C 2 .   ? 1.402   -1.043  3.248   1.00 26.01 ? 312 HOH A O   1 
HETATM 3497 O O   . HOH C 2 .   ? -6.560  -3.195  -3.315  1.00 29.22 ? 313 HOH A O   1 
HETATM 3498 O O   . HOH C 2 .   ? 20.519  -7.258  -10.503 1.00 27.60 ? 314 HOH A O   1 
HETATM 3499 O O   . HOH C 2 .   ? -7.773  -15.602 -2.883  1.00 12.55 ? 315 HOH A O   1 
HETATM 3500 O O   . HOH C 2 .   ? 1.922   -23.291 4.021   1.00 21.41 ? 316 HOH A O   1 
HETATM 3501 O O   . HOH C 2 .   ? 13.774  -3.292  -12.102 1.00 20.51 ? 317 HOH A O   1 
HETATM 3502 O O   . HOH C 2 .   ? 24.424  -11.748 -6.206  1.00 26.35 ? 318 HOH A O   1 
HETATM 3503 O O   . HOH C 2 .   ? 5.733   -14.995 -9.605  1.00 18.29 ? 319 HOH A O   1 
HETATM 3504 O O   . HOH C 2 .   ? 20.799  -20.332 -24.497 1.00 20.32 ? 320 HOH A O   1 
HETATM 3505 O O   . HOH C 2 .   ? 14.038  -5.490  -27.351 1.00 18.95 ? 321 HOH A O   1 
HETATM 3506 O O   . HOH C 2 .   ? 24.445  -12.799 -17.636 1.00 28.72 ? 322 HOH A O   1 
HETATM 3507 O O   . HOH C 2 .   ? 18.719  -27.553 -26.587 1.00 34.28 ? 323 HOH A O   1 
HETATM 3508 O O   . HOH C 2 .   ? 4.936   -21.233 6.483   1.00 35.77 ? 324 HOH A O   1 
HETATM 3509 O O   . HOH C 2 .   ? 3.297   -27.270 -9.655  1.00 19.47 ? 325 HOH A O   1 
HETATM 3510 O O   . HOH C 2 .   ? 22.371  -28.917 -10.650 1.00 22.87 ? 326 HOH A O   1 
HETATM 3511 O O   . HOH C 2 .   ? -1.809  -22.253 5.368   1.00 17.72 ? 327 HOH A O   1 
HETATM 3512 O O   . HOH C 2 .   ? 11.068  -30.296 2.757   1.00 20.86 ? 328 HOH A O   1 
HETATM 3513 O O   . HOH C 2 .   ? 3.119   -13.133 7.775   1.00 20.31 ? 329 HOH A O   1 
HETATM 3514 O O   . HOH C 2 .   ? 25.697  -10.851 -11.140 1.00 27.98 ? 330 HOH A O   1 
HETATM 3515 O O   . HOH C 2 .   ? 7.999   -4.160  -31.588 1.00 28.16 ? 331 HOH A O   1 
HETATM 3516 O O   . HOH C 2 .   ? 6.914   -0.291  -21.384 1.00 23.27 ? 332 HOH A O   1 
HETATM 3517 O O   . HOH C 2 .   ? 13.525  -29.079 2.915   1.00 17.94 ? 333 HOH A O   1 
HETATM 3518 O O   . HOH C 2 .   ? 32.768  -16.222 -28.567 1.00 29.48 ? 334 HOH A O   1 
HETATM 3519 O O   . HOH C 2 .   ? 1.218   0.046   -1.797  1.00 26.89 ? 335 HOH A O   1 
HETATM 3520 O O   . HOH C 2 .   ? 4.037   -7.813  -11.186 1.00 12.36 ? 336 HOH A O   1 
HETATM 3521 O O   . HOH C 2 .   ? 9.430   -8.952  -34.138 1.00 23.85 ? 337 HOH A O   1 
HETATM 3522 O O   . HOH C 2 .   ? -5.528  -3.715  -10.968 1.00 32.34 ? 338 HOH A O   1 
HETATM 3523 O O   . HOH C 2 .   ? 0.152   -22.671 -16.781 1.00 24.40 ? 339 HOH A O   1 
HETATM 3524 O O   . HOH C 2 .   ? 14.620  -7.421  -29.434 1.00 19.09 ? 340 HOH A O   1 
HETATM 3525 O O   . HOH C 2 .   ? 20.344  -16.245 -24.006 1.00 32.57 ? 341 HOH A O   1 
HETATM 3526 O O   . HOH C 2 .   ? 6.647   -15.804 0.406   1.00 11.48 ? 342 HOH A O   1 
HETATM 3527 O O   . HOH C 2 .   ? -9.696  -12.798 -9.486  1.00 34.01 ? 343 HOH A O   1 
HETATM 3528 O O   . HOH C 2 .   ? 19.565  -9.751  -13.337 1.00 15.20 ? 344 HOH A O   1 
HETATM 3529 O O   . HOH C 2 .   ? 2.914   -13.977 -0.049  1.00 10.31 ? 345 HOH A O   1 
HETATM 3530 O O   . HOH C 2 .   ? 26.846  -19.011 -9.122  1.00 18.33 ? 346 HOH A O   1 
HETATM 3531 O O   . HOH C 2 .   ? 31.197  -21.148 -22.220 1.00 36.78 ? 347 HOH A O   1 
HETATM 3532 O O   . HOH C 2 .   ? 18.788  -22.927 -31.024 1.00 25.99 ? 348 HOH A O   1 
HETATM 3533 O O   . HOH C 2 .   ? 22.356  -10.862 -17.680 1.00 18.45 ? 349 HOH A O   1 
HETATM 3534 O O   . HOH C 2 .   ? 14.689  -18.782 8.311   1.00 21.85 ? 350 HOH A O   1 
HETATM 3535 O O   . HOH C 2 .   ? 10.459  -15.009 -7.007  1.00 17.73 ? 351 HOH A O   1 
HETATM 3536 O O   . HOH C 2 .   ? 22.686  -27.819 -3.902  1.00 17.22 ? 352 HOH A O   1 
HETATM 3537 O O   . HOH C 2 .   ? -9.846  -5.904  -12.055 1.00 24.68 ? 353 HOH A O   1 
HETATM 3538 O O   . HOH C 2 .   ? 10.275  -14.588 8.007   1.00 30.62 ? 354 HOH A O   1 
HETATM 3539 O O   . HOH C 2 .   ? 18.516  -11.458 -15.250 1.00 15.23 ? 355 HOH A O   1 
HETATM 3540 O O   . HOH C 2 .   ? 6.274   -15.641 6.274   1.00 23.14 ? 356 HOH A O   1 
HETATM 3541 O O   . HOH C 2 .   ? -3.455  -16.236 7.707   1.00 14.04 ? 357 HOH A O   1 
HETATM 3542 O O   . HOH C 2 .   ? 16.518  -33.024 -18.337 1.00 21.66 ? 358 HOH A O   1 
HETATM 3543 O O   . HOH C 2 .   ? 22.715  -28.509 -6.626  1.00 17.60 ? 359 HOH A O   1 
HETATM 3544 O O   . HOH C 2 .   ? 13.324  -29.293 -0.064  1.00 16.10 ? 360 HOH A O   1 
HETATM 3545 O O   . HOH C 2 .   ? 23.909  -20.924 -7.752  1.00 14.88 ? 361 HOH A O   1 
HETATM 3546 O O   . HOH C 2 .   ? 22.280  -23.257 0.304   1.00 16.57 ? 362 HOH A O   1 
HETATM 3547 O O   . HOH C 2 .   ? -0.139  -4.108  4.483   1.00 29.27 ? 363 HOH A O   1 
HETATM 3548 O O   . HOH C 2 .   ? -3.820  -22.848 -1.622  1.00 23.93 ? 364 HOH A O   1 
HETATM 3549 O O   . HOH C 2 .   ? 21.462  -10.138 -1.172  1.00 24.32 ? 365 HOH A O   1 
HETATM 3550 O O   . HOH C 2 .   ? 13.954  -19.598 5.750   1.00 12.60 ? 366 HOH A O   1 
HETATM 3551 O O   . HOH C 2 .   ? 19.920  -22.927 4.710   1.00 18.88 ? 367 HOH A O   1 
HETATM 3552 O O   . HOH C 2 .   ? 5.645   -13.594 8.140   1.00 19.48 ? 368 HOH A O   1 
HETATM 3553 O O   . HOH C 2 .   ? 19.686  -15.945 3.609   1.00 15.97 ? 369 HOH A O   1 
HETATM 3554 O O   . HOH C 2 .   ? -5.273  -8.699  5.370   1.00 21.78 ? 370 HOH A O   1 
HETATM 3555 O O   . HOH C 2 .   ? 10.345  -1.408  -9.570  1.00 27.02 ? 371 HOH A O   1 
HETATM 3556 O O   . HOH C 2 .   ? 5.925   -26.054 -17.983 1.00 27.42 ? 372 HOH A O   1 
HETATM 3557 O O   . HOH C 2 .   ? 6.301   -19.611 -7.825  1.00 15.05 ? 373 HOH A O   1 
HETATM 3558 O O   . HOH C 2 .   ? 23.332  -18.329 -7.881  1.00 17.88 ? 374 HOH A O   1 
HETATM 3559 O O   . HOH C 2 .   ? 3.802   6.096   1.213   1.00 26.81 ? 375 HOH A O   1 
HETATM 3560 O O   . HOH C 2 .   ? 8.596   -20.304 -11.816 1.00 13.45 ? 376 HOH A O   1 
HETATM 3561 O O   . HOH C 2 .   ? 14.337  -1.706  -29.812 1.00 24.76 ? 377 HOH A O   1 
HETATM 3562 O O   . HOH C 2 .   ? 20.134  -9.831  -5.293  1.00 21.45 ? 378 HOH A O   1 
HETATM 3563 O O   . HOH C 2 .   ? 21.316  -9.885  -23.594 1.00 18.60 ? 379 HOH A O   1 
HETATM 3564 O O   . HOH C 2 .   ? 23.226  -10.572 -20.411 1.00 27.47 ? 380 HOH A O   1 
HETATM 3565 O O   . HOH C 2 .   ? 8.719   -25.400 -26.373 1.00 28.06 ? 381 HOH A O   1 
HETATM 3566 O O   . HOH C 2 .   ? 8.212   -30.189 3.354   1.00 26.72 ? 382 HOH A O   1 
HETATM 3567 O O   . HOH C 2 .   ? 16.332  -7.378  -10.061 1.00 20.42 ? 383 HOH A O   1 
HETATM 3568 O O   . HOH C 2 .   ? 1.234   -11.844 0.703   1.00 16.09 ? 384 HOH A O   1 
HETATM 3569 O O   . HOH C 2 .   ? -4.654  -11.187 10.297  1.00 35.47 ? 385 HOH A O   1 
HETATM 3570 O O   . HOH C 2 .   ? 7.133   -20.080 -5.135  1.00 14.09 ? 386 HOH A O   1 
HETATM 3571 O O   . HOH C 2 .   ? 9.331   -23.894 9.172   1.00 26.69 ? 387 HOH A O   1 
HETATM 3572 O O   . HOH C 2 .   ? -13.164 -13.327 -7.764  1.00 20.85 ? 388 HOH A O   1 
HETATM 3573 O O   . HOH C 2 .   ? 7.994   0.036   -10.175 1.00 25.80 ? 389 HOH A O   1 
HETATM 3574 O O   . HOH C 2 .   ? 13.945  -14.561 -3.431  1.00 15.21 ? 390 HOH A O   1 
HETATM 3575 O O   . HOH C 2 .   ? 9.205   -29.790 7.682   1.00 38.58 ? 391 HOH A O   1 
HETATM 3576 O O   . HOH C 2 .   ? -11.566 -6.077  -5.543  1.00 27.23 ? 392 HOH A O   1 
HETATM 3577 O O   . HOH C 2 .   ? 14.106  -0.480  -11.304 1.00 35.94 ? 393 HOH A O   1 
HETATM 3578 O O   . HOH C 2 .   ? 11.195  -14.204 -4.389  1.00 16.15 ? 394 HOH A O   1 
HETATM 3579 O O   . HOH C 2 .   ? 20.116  -27.548 -13.835 1.00 27.16 ? 395 HOH A O   1 
HETATM 3580 O O   . HOH C 2 .   ? 20.611  -26.517 -24.906 1.00 29.67 ? 396 HOH A O   1 
HETATM 3581 O O   . HOH C 2 .   ? 10.227  -12.061 8.728   1.00 27.63 ? 397 HOH A O   1 
HETATM 3582 O O   . HOH C 2 .   ? 11.667  -23.031 -32.630 1.00 25.42 ? 398 HOH A O   1 
HETATM 3583 O O   . HOH C 2 .   ? 3.570   -10.504 -32.874 1.00 22.61 ? 399 HOH A O   1 
HETATM 3584 O O   . HOH C 2 .   ? -5.161  -20.786 -8.425  1.00 23.30 ? 400 HOH A O   1 
HETATM 3585 O O   . HOH C 2 .   ? 14.667  -31.538 -0.746  1.00 25.55 ? 401 HOH A O   1 
HETATM 3586 O O   . HOH C 2 .   ? -0.349  -11.564 9.172   1.00 26.27 ? 402 HOH A O   1 
HETATM 3587 O O   . HOH C 2 .   ? 14.193  -2.953  -4.413  1.00 25.38 ? 403 HOH A O   1 
HETATM 3588 O O   . HOH C 2 .   ? 5.870   -17.085 -7.695  1.00 17.23 ? 404 HOH A O   1 
HETATM 3589 O O   . HOH C 2 .   ? -2.838  -8.654  -13.777 1.00 33.61 ? 405 HOH A O   1 
HETATM 3590 O O   . HOH C 2 .   ? 1.906   -24.203 -16.042 1.00 20.11 ? 406 HOH A O   1 
HETATM 3591 O O   . HOH C 2 .   ? 26.934  -21.518 -15.247 1.00 30.19 ? 407 HOH A O   1 
HETATM 3592 O O   . HOH C 2 .   ? 21.549  -13.973 -22.584 1.00 20.36 ? 408 HOH A O   1 
HETATM 3593 O O   . HOH C 2 .   ? 7.737   -9.556  12.004  1.00 28.09 ? 409 HOH A O   1 
HETATM 3594 O O   . HOH C 2 .   ? 6.013   -4.607  9.393   1.00 24.74 ? 410 HOH A O   1 
HETATM 3595 O O   . HOH C 2 .   ? 4.314   -24.001 5.937   1.00 31.20 ? 411 HOH A O   1 
HETATM 3596 O O   . HOH C 2 .   ? 5.679   -32.997 0.699   1.00 27.39 ? 412 HOH A O   1 
HETATM 3597 O O   . HOH C 2 .   ? 8.929   -14.696 5.935   1.00 16.05 ? 413 HOH A O   1 
HETATM 3598 O O   . HOH C 2 .   ? -3.411  -15.688 -11.671 1.00 30.32 ? 414 HOH A O   1 
HETATM 3599 O O   . HOH C 2 .   ? -1.158  -6.550  4.884   1.00 25.91 ? 415 HOH A O   1 
HETATM 3600 O O   . HOH C 2 .   ? 20.419  -11.802 -20.912 1.00 16.16 ? 416 HOH A O   1 
HETATM 3601 O O   . HOH C 2 .   ? -4.504  -0.421  -7.282  1.00 35.25 ? 417 HOH A O   1 
HETATM 3602 O O   . HOH C 2 .   ? 5.565   -10.864 -2.945  1.00 29.64 ? 418 HOH A O   1 
HETATM 3603 O O   . HOH C 2 .   ? 1.502   -17.201 -21.740 1.00 30.67 ? 419 HOH A O   1 
HETATM 3604 O O   . HOH C 2 .   ? 12.986  -26.029 9.280   1.00 22.52 ? 420 HOH A O   1 
HETATM 3605 O O   . HOH C 2 .   ? 1.464   -15.376 7.110   1.00 13.15 ? 421 HOH A O   1 
HETATM 3606 O O   . HOH C 2 .   ? 19.838  -2.169  -8.631  1.00 25.10 ? 422 HOH A O   1 
HETATM 3607 O O   . HOH C 2 .   ? 7.357   -11.086 -33.576 1.00 26.46 ? 423 HOH A O   1 
HETATM 3608 O O   . HOH C 2 .   ? 22.412  -9.830  -13.311 1.00 16.38 ? 424 HOH A O   1 
HETATM 3609 O O   . HOH C 2 .   ? 5.205   -13.447 -1.818  1.00 14.36 ? 425 HOH A O   1 
HETATM 3610 O O   . HOH C 2 .   ? -4.686  -17.949 5.991   1.00 14.01 ? 426 HOH A O   1 
HETATM 3611 O O   . HOH C 2 .   ? 13.077  -11.946 -34.520 1.00 27.35 ? 427 HOH A O   1 
HETATM 3612 O O   . HOH C 2 .   ? 15.153  -26.529 7.295   1.00 20.53 ? 428 HOH A O   1 
HETATM 3613 O O   . HOH C 2 .   ? 23.349  -24.347 -14.087 1.00 20.23 ? 429 HOH A O   1 
HETATM 3614 O O   . HOH C 2 .   ? -3.883  -23.865 1.226   1.00 33.95 ? 430 HOH A O   1 
HETATM 3615 O O   . HOH C 2 .   ? -0.821  -15.163 -19.428 1.00 32.06 ? 431 HOH A O   1 
HETATM 3616 O O   . HOH C 2 .   ? 7.059   -3.708  7.100   1.00 21.89 ? 432 HOH A O   1 
HETATM 3617 O O   A HOH C 2 .   ? 0.678   -19.124 -26.829 0.50 19.77 ? 433 HOH A O   1 
HETATM 3618 O O   B HOH C 2 .   ? 0.501   -16.957 -26.551 0.50 16.44 ? 433 HOH A O   1 
HETATM 3619 O O   A HOH C 2 .   ? -10.078 -8.556  -2.950  0.50 4.44  ? 434 HOH A O   1 
HETATM 3620 O O   B HOH C 2 .   ? -10.055 -8.424  -1.220  0.50 16.63 ? 434 HOH A O   1 
HETATM 3621 O O   . HOH C 2 .   ? 30.931  -17.070 -11.678 1.00 39.56 ? 435 HOH A O   1 
HETATM 3622 O O   . HOH C 2 .   ? 29.017  -22.546 -17.259 1.00 28.06 ? 436 HOH A O   1 
HETATM 3623 O O   . HOH C 2 .   ? 26.129  -11.844 -15.549 1.00 32.91 ? 437 HOH A O   1 
HETATM 3624 O O   . HOH C 2 .   ? 10.342  -8.725  8.161   1.00 28.36 ? 438 HOH A O   1 
HETATM 3625 O O   . HOH C 2 .   ? 23.269  -11.862 -22.944 1.00 28.05 ? 439 HOH A O   1 
HETATM 3626 O O   . HOH C 2 .   ? 2.530   -20.140 5.936   1.00 28.57 ? 440 HOH A O   1 
HETATM 3627 O O   . HOH C 2 .   ? 29.593  -18.627 -9.663  1.00 22.63 ? 441 HOH A O   1 
HETATM 3628 O O   . HOH C 2 .   ? 23.627  -9.746  -15.546 1.00 25.07 ? 442 HOH A O   1 
HETATM 3629 O O   . HOH C 2 .   ? 11.247  -27.085 -27.605 1.00 33.65 ? 443 HOH A O   1 
HETATM 3630 O O   . HOH C 2 .   ? -2.432  -9.661  9.293   1.00 30.11 ? 444 HOH A O   1 
HETATM 3631 O O   . HOH C 2 .   ? -4.000  -8.330  7.746   1.00 26.01 ? 445 HOH A O   1 
HETATM 3632 O O   . HOH C 2 .   ? 1.513   -0.547  10.464  1.00 54.72 ? 446 HOH A O   1 
HETATM 3633 O O   . HOH C 2 .   ? -0.903  -13.799 10.299  1.00 19.05 ? 447 HOH A O   1 
HETATM 3634 O O   . HOH C 2 .   ? 7.685   -31.170 -15.876 1.00 37.62 ? 448 HOH A O   1 
HETATM 3635 O O   . HOH C 2 .   ? -0.890  -15.553 8.613   1.00 19.23 ? 449 HOH A O   1 
HETATM 3636 O O   . HOH C 2 .   ? 23.118  -27.300 -25.400 1.00 36.50 ? 450 HOH A O   1 
HETATM 3637 O O   . HOH C 2 .   ? 30.385  -20.680 -10.082 1.00 31.61 ? 451 HOH A O   1 
HETATM 3638 O O   . HOH C 2 .   ? 26.857  -18.454 -6.437  1.00 18.68 ? 452 HOH A O   1 
HETATM 3639 O O   . HOH C 2 .   ? 24.549  -16.988 -5.662  1.00 16.98 ? 453 HOH A O   1 
HETATM 3640 O O   . HOH C 2 .   ? 5.936   -14.686 10.629  1.00 28.91 ? 454 HOH A O   1 
HETATM 3641 O O   . HOH C 2 .   ? -2.912  -24.540 5.812   1.00 27.60 ? 455 HOH A O   1 
HETATM 3642 O O   . HOH C 2 .   ? 27.974  -25.418 -14.566 1.00 29.13 ? 456 HOH A O   1 
HETATM 3643 O O   . HOH C 2 .   ? 0.643   -22.084 6.801   1.00 32.24 ? 457 HOH A O   1 
HETATM 3644 O O   . HOH C 2 .   ? 5.288   -17.753 7.373   1.00 27.94 ? 458 HOH A O   1 
HETATM 3645 O O   . HOH C 2 .   ? 16.423  -4.203  -3.177  1.00 42.02 ? 459 HOH A O   1 
HETATM 3646 O O   . HOH C 2 .   ? 20.824  -8.580  -3.130  1.00 25.92 ? 460 HOH A O   1 
HETATM 3647 O O   . HOH C 2 .   ? 2.732   -17.666 7.189   1.00 24.97 ? 461 HOH A O   1 
HETATM 3648 O O   . HOH C 2 .   ? 25.080  -14.130 -5.303  1.00 27.61 ? 462 HOH A O   1 
HETATM 3649 O O   . HOH C 2 .   ? 6.656   -17.718 10.087  1.00 32.88 ? 463 HOH A O   1 
HETATM 3650 O O   . HOH D 2 .   ? -3.819  -9.952  -43.892 1.00 28.40 ? 301 HOH B O   1 
HETATM 3651 O O   . HOH D 2 .   ? 4.002   -24.111 -34.525 1.00 32.22 ? 302 HOH B O   1 
HETATM 3652 O O   . HOH D 2 .   ? -14.080 -8.218  -50.691 1.00 36.53 ? 303 HOH B O   1 
HETATM 3653 O O   . HOH D 2 .   ? 10.252  -24.091 -41.585 1.00 26.63 ? 304 HOH B O   1 
HETATM 3654 O O   . HOH D 2 .   ? 5.976   -16.645 -28.986 1.00 31.16 ? 305 HOH B O   1 
HETATM 3655 O O   . HOH D 2 .   ? 11.850  -12.983 -39.000 1.00 31.61 ? 306 HOH B O   1 
HETATM 3656 O O   . HOH D 2 .   ? 0.979   -30.898 -45.541 1.00 26.45 ? 307 HOH B O   1 
HETATM 3657 O O   . HOH D 2 .   ? 6.165   -28.985 -41.409 1.00 32.56 ? 308 HOH B O   1 
HETATM 3658 O O   . HOH D 2 .   ? -0.010  -23.297 -52.388 1.00 27.77 ? 309 HOH B O   1 
HETATM 3659 O O   . HOH D 2 .   ? -11.723 -4.984  -20.901 1.00 19.97 ? 310 HOH B O   1 
HETATM 3660 O O   . HOH D 2 .   ? -11.864 -23.758 -17.223 1.00 22.95 ? 311 HOH B O   1 
HETATM 3661 O O   . HOH D 2 .   ? 11.751  -6.240  -36.331 1.00 21.14 ? 312 HOH B O   1 
HETATM 3662 O O   . HOH D 2 .   ? -20.992 -9.900  -28.143 1.00 24.15 ? 313 HOH B O   1 
HETATM 3663 O O   . HOH D 2 .   ? -20.376 0.930   -30.832 1.00 31.18 ? 314 HOH B O   1 
HETATM 3664 O O   . HOH D 2 .   ? 7.268   -14.049 -34.290 1.00 28.34 ? 315 HOH B O   1 
HETATM 3665 O O   . HOH D 2 .   ? -3.832  -14.887 -38.771 1.00 19.53 ? 316 HOH B O   1 
HETATM 3666 O O   . HOH D 2 .   ? -11.848 -28.712 -51.251 1.00 25.60 ? 317 HOH B O   1 
HETATM 3667 O O   . HOH D 2 .   ? -24.846 -18.554 -39.230 1.00 15.88 ? 318 HOH B O   1 
HETATM 3668 O O   . HOH D 2 .   ? -20.386 -28.279 -37.362 1.00 26.84 ? 319 HOH B O   1 
HETATM 3669 O O   . HOH D 2 .   ? -14.108 0.360   -39.790 1.00 26.44 ? 320 HOH B O   1 
HETATM 3670 O O   . HOH D 2 .   ? -5.667  -21.132 -14.366 1.00 26.37 ? 321 HOH B O   1 
HETATM 3671 O O   . HOH D 2 .   ? -18.527 -6.837  -37.864 1.00 22.08 ? 322 HOH B O   1 
HETATM 3672 O O   . HOH D 2 .   ? -15.909 -27.858 -42.788 1.00 21.36 ? 323 HOH B O   1 
HETATM 3673 O O   . HOH D 2 .   ? -14.819 -11.799 -53.196 1.00 31.96 ? 324 HOH B O   1 
HETATM 3674 O O   . HOH D 2 .   ? -0.905  -13.166 -56.231 1.00 19.68 ? 325 HOH B O   1 
HETATM 3675 O O   . HOH D 2 .   ? -1.384  -27.153 -38.501 1.00 19.37 ? 326 HOH B O   1 
HETATM 3676 O O   . HOH D 2 .   ? -17.500 -9.273  -35.172 1.00 13.48 ? 327 HOH B O   1 
HETATM 3677 O O   . HOH D 2 .   ? 10.378  -15.795 -48.085 1.00 13.58 ? 328 HOH B O   1 
HETATM 3678 O O   . HOH D 2 .   ? -21.043 -7.270  -42.058 1.00 30.71 ? 329 HOH B O   1 
HETATM 3679 O O   . HOH D 2 .   ? -13.719 2.441   -24.402 1.00 28.13 ? 330 HOH B O   1 
HETATM 3680 O O   . HOH D 2 .   ? -1.967  -7.706  -37.198 1.00 13.44 ? 331 HOH B O   1 
HETATM 3681 O O   . HOH D 2 .   ? -11.421 -28.929 -48.284 1.00 16.20 ? 332 HOH B O   1 
HETATM 3682 O O   . HOH D 2 .   ? 5.549   -14.067 -58.714 1.00 19.44 ? 333 HOH B O   1 
HETATM 3683 O O   . HOH D 2 .   ? -20.213 -10.262 -30.899 1.00 18.51 ? 334 HOH B O   1 
HETATM 3684 O O   . HOH D 2 .   ? -18.963 -19.698 -23.852 1.00 18.28 ? 335 HOH B O   1 
HETATM 3685 O O   . HOH D 2 .   ? -12.420 -6.966  -19.029 1.00 17.74 ? 336 HOH B O   1 
HETATM 3686 O O   . HOH D 2 .   ? -0.939  -13.924 -48.342 1.00 10.53 ? 337 HOH B O   1 
HETATM 3687 O O   . HOH D 2 .   ? 4.961   -9.165  -34.442 1.00 34.61 ? 338 HOH B O   1 
HETATM 3688 O O   . HOH D 2 .   ? -19.360 -9.801  -47.469 1.00 23.43 ? 339 HOH B O   1 
HETATM 3689 O O   . HOH D 2 .   ? -5.844  -3.823  -16.817 1.00 27.70 ? 340 HOH B O   1 
HETATM 3690 O O   . HOH D 2 .   ? -17.183 -21.882 -16.942 1.00 25.49 ? 341 HOH B O   1 
HETATM 3691 O O   . HOH D 2 .   ? -22.352 -11.432 -42.240 1.00 23.97 ? 342 HOH B O   1 
HETATM 3692 O O   . HOH D 2 .   ? -11.645 -2.856  -36.320 1.00 18.43 ? 343 HOH B O   1 
HETATM 3693 O O   . HOH D 2 .   ? -21.202 -1.504  -23.201 1.00 28.01 ? 344 HOH B O   1 
HETATM 3694 O O   . HOH D 2 .   ? -16.490 -11.002 -33.187 1.00 14.81 ? 345 HOH B O   1 
HETATM 3695 O O   . HOH D 2 .   ? -4.518  -0.029  -27.082 1.00 25.42 ? 346 HOH B O   1 
HETATM 3696 O O   . HOH D 2 .   ? -21.946 -20.563 -40.653 1.00 13.51 ? 347 HOH B O   1 
HETATM 3697 O O   . HOH D 2 .   ? -4.227  -15.492 -54.653 1.00 21.58 ? 348 HOH B O   1 
HETATM 3698 O O   . HOH D 2 .   ? -20.945 -22.899 -51.167 1.00 13.72 ? 349 HOH B O   1 
HETATM 3699 O O   . HOH D 2 .   ? -12.490 -30.996 -47.337 1.00 29.05 ? 350 HOH B O   1 
HETATM 3700 O O   . HOH D 2 .   ? 7.348   -9.093  -53.805 1.00 20.77 ? 351 HOH B O   1 
HETATM 3701 O O   . HOH D 2 .   ? -24.195 -23.077 -34.502 1.00 20.00 ? 352 HOH B O   1 
HETATM 3702 O O   . HOH D 2 .   ? 7.610   -3.868  -37.311 1.00 30.87 ? 353 HOH B O   1 
HETATM 3703 O O   . HOH D 2 .   ? -4.332  -25.857 -30.065 1.00 29.28 ? 354 HOH B O   1 
HETATM 3704 O O   . HOH D 2 .   ? -20.017 -16.554 -22.370 1.00 29.66 ? 355 HOH B O   1 
HETATM 3705 O O   . HOH D 2 .   ? 9.991   -11.302 -52.298 1.00 13.91 ? 356 HOH B O   1 
HETATM 3706 O O   . HOH D 2 .   ? -6.563  -29.938 -52.151 1.00 26.53 ? 357 HOH B O   1 
HETATM 3707 O O   . HOH D 2 .   ? -21.256 -8.029  -37.433 1.00 26.66 ? 358 HOH B O   1 
HETATM 3708 O O   . HOH D 2 .   ? -21.324 -17.749 -40.589 1.00 14.46 ? 359 HOH B O   1 
HETATM 3709 O O   . HOH D 2 .   ? 3.783   -22.361 -53.733 1.00 16.82 ? 360 HOH B O   1 
HETATM 3710 O O   . HOH D 2 .   ? -4.306  -19.440 -40.421 1.00 13.74 ? 361 HOH B O   1 
HETATM 3711 O O   . HOH D 2 .   ? -19.208 -9.277  -24.886 1.00 14.34 ? 362 HOH B O   1 
HETATM 3712 O O   . HOH D 2 .   ? -4.591  -15.639 -48.820 1.00 14.35 ? 363 HOH B O   1 
HETATM 3713 O O   . HOH D 2 .   ? -8.504  -14.685 -41.325 1.00 17.90 ? 364 HOH B O   1 
HETATM 3714 O O   . HOH D 2 .   ? -12.100 -1.240  -18.616 1.00 25.03 ? 365 HOH B O   1 
HETATM 3715 O O   . HOH D 2 .   ? -2.003  -34.673 -46.932 1.00 23.22 ? 366 HOH B O   1 
HETATM 3716 O O   . HOH D 2 .   ? -18.142 -9.398  -43.145 1.00 18.07 ? 367 HOH B O   1 
HETATM 3717 O O   . HOH D 2 .   ? -2.385  -24.144 -54.202 1.00 24.33 ? 368 HOH B O   1 
HETATM 3718 O O   . HOH D 2 .   ? -3.509  -13.545 -56.472 1.00 18.92 ? 369 HOH B O   1 
HETATM 3719 O O   . HOH D 2 .   ? -9.190  -30.058 -51.359 1.00 20.91 ? 370 HOH B O   1 
HETATM 3720 O O   . HOH D 2 .   ? -25.293 -22.255 -40.584 1.00 14.22 ? 371 HOH B O   1 
HETATM 3721 O O   . HOH D 2 .   ? -6.640  -20.095 -36.433 1.00 15.75 ? 372 HOH B O   1 
HETATM 3722 O O   . HOH D 2 .   ? -18.780 -15.161 -24.290 1.00 22.28 ? 373 HOH B O   1 
HETATM 3723 O O   . HOH D 2 .   ? -24.988 -20.833 -33.295 1.00 29.05 ? 374 HOH B O   1 
HETATM 3724 O O   . HOH D 2 .   ? -5.153  -20.013 -43.301 1.00 11.61 ? 375 HOH B O   1 
HETATM 3725 O O   . HOH D 2 .   ? -23.440 -10.060 -37.548 1.00 28.79 ? 376 HOH B O   1 
HETATM 3726 O O   . HOH D 2 .   ? -17.911 -22.754 -53.091 1.00 17.38 ? 377 HOH B O   1 
HETATM 3727 O O   . HOH D 2 .   ? -14.194 -6.981  -38.476 1.00 15.89 ? 378 HOH B O   1 
HETATM 3728 O O   . HOH D 2 .   ? 0.721   -11.812 -49.033 1.00 12.40 ? 379 HOH B O   1 
HETATM 3729 O O   . HOH D 2 .   ? 9.206   -8.392  -50.274 1.00 22.80 ? 380 HOH B O   1 
HETATM 3730 O O   . HOH D 2 .   ? -6.954  -14.469 -54.294 1.00 18.18 ? 381 HOH B O   1 
HETATM 3731 O O   . HOH D 2 .   ? -9.101  -13.883 -43.886 1.00 15.69 ? 382 HOH B O   1 
HETATM 3732 O O   . HOH D 2 .   ? -7.201  -8.508  -14.237 1.00 24.07 ? 383 HOH B O   1 
HETATM 3733 O O   . HOH D 2 .   ? -22.471 -11.925 -31.042 1.00 20.60 ? 384 HOH B O   1 
HETATM 3734 O O   . HOH D 2 .   ? -9.848  -22.668 -15.669 1.00 20.55 ? 385 HOH B O   1 
HETATM 3735 O O   . HOH D 2 .   ? -25.296 -11.119 -27.074 1.00 29.12 ? 386 HOH B O   1 
HETATM 3736 O O   . HOH D 2 .   ? -15.980 -12.431 -15.724 1.00 33.02 ? 387 HOH B O   1 
HETATM 3737 O O   . HOH D 2 .   ? 15.094  -13.629 -40.553 1.00 23.40 ? 388 HOH B O   1 
HETATM 3738 O O   . HOH D 2 .   ? 5.774   -22.924 -46.615 1.00 18.58 ? 389 HOH B O   1 
HETATM 3739 O O   . HOH D 2 .   ? 0.194   -4.434  -30.227 1.00 29.09 ? 390 HOH B O   1 
HETATM 3740 O O   . HOH D 2 .   ? -3.961  -16.956 -40.709 1.00 18.13 ? 391 HOH B O   1 
HETATM 3741 O O   . HOH D 2 .   ? -5.494  -9.151  -60.332 1.00 30.35 ? 392 HOH B O   1 
HETATM 3742 O O   . HOH D 2 .   ? -17.613 -15.600 -52.040 1.00 16.21 ? 393 HOH B O   1 
HETATM 3743 O O   . HOH D 2 .   ? -11.916 -14.391 -44.993 1.00 15.97 ? 394 HOH B O   1 
HETATM 3744 O O   . HOH D 2 .   ? 0.588   -15.408 -55.417 1.00 14.50 ? 395 HOH B O   1 
HETATM 3745 O O   . HOH D 2 .   ? 4.644   -26.847 -48.961 1.00 19.83 ? 396 HOH B O   1 
HETATM 3746 O O   . HOH D 2 .   ? 7.004   -20.953 -39.653 1.00 23.70 ? 397 HOH B O   1 
HETATM 3747 O O   . HOH D 2 .   ? -11.579 -0.145  -37.313 1.00 25.93 ? 398 HOH B O   1 
HETATM 3748 O O   . HOH D 2 .   ? -12.041 -19.340 -54.183 1.00 15.25 ? 399 HOH B O   1 
HETATM 3749 O O   . HOH D 2 .   ? -20.697 -28.112 -41.747 1.00 14.64 ? 400 HOH B O   1 
HETATM 3750 O O   . HOH D 2 .   ? -27.456 -23.953 -27.068 1.00 32.20 ? 401 HOH B O   1 
HETATM 3751 O O   . HOH D 2 .   ? -8.339  -14.296 -56.535 1.00 29.41 ? 402 HOH B O   1 
HETATM 3752 O O   . HOH D 2 .   ? -0.700  -2.973  -23.249 1.00 33.80 ? 403 HOH B O   1 
HETATM 3753 O O   . HOH D 2 .   ? -0.371  -24.374 -32.173 1.00 22.51 ? 404 HOH B O   1 
HETATM 3754 O O   . HOH D 2 .   ? -12.744 -18.609 -56.699 1.00 21.24 ? 405 HOH B O   1 
HETATM 3755 O O   . HOH D 2 .   ? -26.686 -20.593 -24.057 1.00 32.01 ? 406 HOH B O   1 
HETATM 3756 O O   . HOH D 2 .   ? -17.081 -26.948 -21.777 1.00 20.00 ? 407 HOH B O   1 
HETATM 3757 O O   . HOH D 2 .   ? -5.711  0.132   -38.408 1.00 24.26 ? 408 HOH B O   1 
HETATM 3758 O O   . HOH D 2 .   ? 6.645   -11.497 -58.782 1.00 47.09 ? 409 HOH B O   1 
HETATM 3759 O O   . HOH D 2 .   ? -8.222  -0.842  -38.912 1.00 26.58 ? 410 HOH B O   1 
HETATM 3760 O O   . HOH D 2 .   ? -15.747 -31.025 -48.904 1.00 28.66 ? 411 HOH B O   1 
HETATM 3761 O O   . HOH D 2 .   ? -17.538 -1.741  -39.782 1.00 27.25 ? 412 HOH B O   1 
HETATM 3762 O O   . HOH D 2 .   ? -12.164 -2.729  -43.964 1.00 29.56 ? 413 HOH B O   1 
HETATM 3763 O O   . HOH D 2 .   ? -17.540 -2.785  -18.599 1.00 32.06 ? 414 HOH B O   1 
HETATM 3764 O O   . HOH D 2 .   ? -18.378 -11.115 -27.462 1.00 15.59 ? 415 HOH B O   1 
HETATM 3765 O O   . HOH D 2 .   ? -6.869  -25.057 -21.859 1.00 21.98 ? 416 HOH B O   1 
HETATM 3766 O O   . HOH D 2 .   ? -11.142 -11.503 -14.053 1.00 21.15 ? 417 HOH B O   1 
HETATM 3767 O O   . HOH D 2 .   ? -5.464  -10.506 -14.836 1.00 24.43 ? 418 HOH B O   1 
HETATM 3768 O O   . HOH D 2 .   ? -20.302 -9.322  -35.240 1.00 13.99 ? 419 HOH B O   1 
HETATM 3769 O O   . HOH D 2 .   ? -11.059 -25.815 -57.625 1.00 20.68 ? 420 HOH B O   1 
HETATM 3770 O O   . HOH D 2 .   ? -1.562  -9.863  -15.507 1.00 22.82 ? 421 HOH B O   1 
HETATM 3771 O O   . HOH D 2 .   ? 3.325   -6.709  -53.502 1.00 21.91 ? 422 HOH B O   1 
HETATM 3772 O O   . HOH D 2 .   ? -3.141  -10.684 -45.994 1.00 31.00 ? 423 HOH B O   1 
HETATM 3773 O O   . HOH D 2 .   ? -21.569 -23.666 -34.263 1.00 18.36 ? 424 HOH B O   1 
HETATM 3774 O O   . HOH D 2 .   ? -28.010 -16.247 -32.952 1.00 27.65 ? 425 HOH B O   1 
HETATM 3775 O O   . HOH D 2 .   ? 5.527   -15.700 -36.534 1.00 24.87 ? 426 HOH B O   1 
HETATM 3776 O O   . HOH D 2 .   ? -3.094  -13.358 -46.631 1.00 14.72 ? 427 HOH B O   1 
HETATM 3777 O O   . HOH D 2 .   ? -16.001 5.331   -27.612 1.00 23.74 ? 428 HOH B O   1 
HETATM 3778 O O   . HOH D 2 .   ? -19.638 -13.220 -25.729 1.00 20.34 ? 429 HOH B O   1 
HETATM 3779 O O   . HOH D 2 .   ? 6.651   -18.266 -54.193 1.00 13.38 ? 430 HOH B O   1 
HETATM 3780 O O   . HOH D 2 .   ? -5.000  -3.323  -55.639 1.00 24.87 ? 431 HOH B O   1 
HETATM 3781 O O   . HOH D 2 .   ? -17.844 -16.536 -54.469 1.00 30.95 ? 432 HOH B O   1 
HETATM 3782 O O   . HOH D 2 .   ? -13.241 -26.328 -55.635 1.00 20.25 ? 433 HOH B O   1 
HETATM 3783 O O   . HOH D 2 .   ? -23.092 -26.163 -25.362 1.00 31.21 ? 434 HOH B O   1 
HETATM 3784 O O   . HOH D 2 .   ? 0.315   -21.301 -24.810 1.00 30.80 ? 435 HOH B O   1 
HETATM 3785 O O   . HOH D 2 .   ? 1.293   -19.354 -21.248 1.00 25.02 ? 436 HOH B O   1 
HETATM 3786 O O   . HOH D 2 .   ? -3.348  -2.271  -16.386 1.00 32.16 ? 437 HOH B O   1 
HETATM 3787 O O   . HOH D 2 .   ? 2.918   -15.287 -28.900 1.00 34.15 ? 438 HOH B O   1 
HETATM 3788 O O   . HOH D 2 .   ? -28.861 -16.828 -36.794 1.00 33.42 ? 439 HOH B O   1 
HETATM 3789 O O   . HOH D 2 .   ? -16.035 -6.043  -11.496 1.00 33.19 ? 440 HOH B O   1 
HETATM 3790 O O   . HOH D 2 .   ? 12.247  -8.867  -45.532 1.00 17.20 ? 441 HOH B O   1 
HETATM 3791 O O   . HOH D 2 .   ? -21.545 -9.074  -32.784 1.00 20.17 ? 442 HOH B O   1 
HETATM 3792 O O   . HOH D 2 .   ? 3.107   -21.888 -33.673 1.00 27.80 ? 443 HOH B O   1 
HETATM 3793 O O   . HOH D 2 .   ? -23.925 -11.097 -33.086 1.00 29.86 ? 444 HOH B O   1 
HETATM 3794 O O   . HOH D 2 .   ? -18.960 -27.386 -34.740 1.00 44.11 ? 445 HOH B O   1 
HETATM 3795 O O   . HOH D 2 .   ? -16.063 -22.571 -55.140 1.00 24.95 ? 446 HOH B O   1 
HETATM 3796 O O   . HOH D 2 .   ? -0.539  -20.165 -54.180 1.00 27.07 ? 447 HOH B O   1 
HETATM 3797 O O   . HOH D 2 .   ? -21.260 -11.176 -25.583 1.00 25.99 ? 448 HOH B O   1 
HETATM 3798 O O   . HOH D 2 .   ? 4.465   -10.111 -58.112 1.00 34.74 ? 449 HOH B O   1 
HETATM 3799 O O   . HOH D 2 .   ? -27.673 -18.190 -38.787 1.00 25.88 ? 450 HOH B O   1 
HETATM 3800 O O   . HOH D 2 .   ? -10.315 -3.748  -52.511 1.00 30.03 ? 451 HOH B O   1 
HETATM 3801 O O   . HOH D 2 .   ? -2.703  -36.800 -45.030 1.00 29.99 ? 452 HOH B O   1 
HETATM 3802 O O   A HOH D 2 .   ? 2.940   -13.941 -58.726 0.50 7.06  ? 453 HOH B O   1 
HETATM 3803 O O   B HOH D 2 .   ? 2.279   -11.711 -57.669 0.50 18.79 ? 453 HOH B O   1 
HETATM 3804 O O   . HOH D 2 .   ? -24.210 -10.567 -40.512 1.00 31.85 ? 454 HOH B O   1 
HETATM 3805 O O   . HOH D 2 .   ? -22.607 -16.633 -42.754 1.00 16.41 ? 455 HOH B O   1 
HETATM 3806 O O   . HOH D 2 .   ? 2.823   -15.952 -56.930 1.00 19.06 ? 456 HOH B O   1 
HETATM 3807 O O   . HOH D 2 .   ? -24.804 -18.186 -42.097 1.00 15.87 ? 457 HOH B O   1 
HETATM 3808 O O   . HOH D 2 .   ? -14.198 -4.264  -45.334 1.00 34.66 ? 458 HOH B O   1 
HETATM 3809 O O   . HOH D 2 .   ? -28.550 -20.582 -38.393 1.00 33.45 ? 459 HOH B O   1 
HETATM 3810 O O   . HOH D 2 .   ? -3.377  -17.560 -55.809 1.00 31.68 ? 460 HOH B O   1 
HETATM 3811 O O   . HOH D 2 .   ? -18.504 -8.163  -45.540 1.00 20.97 ? 461 HOH B O   1 
HETATM 3812 O O   . HOH D 2 .   ? -26.099 -25.147 -33.858 1.00 25.56 ? 462 HOH B O   1 
HETATM 3813 O O   . HOH D 2 .   ? -0.724  -17.721 -55.448 1.00 27.30 ? 463 HOH B O   1 
HETATM 3814 O O   . HOH D 2 .   ? 0.842   -26.530 -32.843 1.00 28.79 ? 464 HOH B O   1 
HETATM 3815 O O   . HOH D 2 .   ? -22.987 -13.864 -43.203 1.00 19.64 ? 465 HOH B O   1 
HETATM 3816 O O   . HOH D 2 .   ? -4.410  -17.680 -58.585 1.00 32.25 ? 466 HOH B O   1 
# 
