data_9FEG
# 
_entry.id   9FEG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FEG         pdb_00009feg 10.2210/pdb9feg/pdb 
WWPDB D_1292138721 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FEG 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              Lari.Lehtio@oulu.fi 
_pdbx_contact_author.name_first         Lari 
_pdbx_contact_author.name_last          Lehtio 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7250-832X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bosetti, C.' 1 ? 
'Lehtio, L.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   FR 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Eur.J.Med.Chem. 
_citation.journal_id_ASTM           EJMCA5 
_citation.journal_id_CSD            0493 
_citation.journal_id_ISSN           0223-5234 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            288 
_citation.language                  ? 
_citation.page_first                117397 
_citation.page_last                 117397 
_citation.title                     
'Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ejmech.2025.117397 
_citation.pdbx_database_id_PubMed   39983556 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bosetti, C.'     1  ? 
primary 'Kampasis, D.'    2  ? 
primary 'Brinch, S.A.'    3  ? 
primary 'Galera-Prat, A.' 4  ? 
primary 'Karelou, M.'     5  ? 
primary 'Dhakar, S.S.'    6  ? 
primary 'Alaviuhkola, J.' 7  ? 
primary 'Waaler, J.'      8  ? 
primary 'Lehtio, L.'      9  ? 
primary 'Kostakis, I.K.'  10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Protein mono-ADP-ribosyltransferase PARP15'                                                                  
22967.785 2   2.4.2.- ? ? ? 
2 non-polymer syn 'DIMETHYL SULFOXIDE'                                                                                          
78.133    1   ?       ? ? ? 
3 non-polymer syn '(4S)-2-METHYL-2,4-PENTANEDIOL'                                                                               
118.174   1   ?       ? ? ? 
4 non-polymer syn '(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' 
381.425   1   ?       ? ? ? 
5 water       nat water                                                                                                         
18.015    214 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'ADP-ribosyltransferase diphtheria toxin-like 7,ARTD7,B-aggressive lymphoma protein 3,Poly [ADP-ribose] polymerase 15,PARP-15' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SMNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLF
HGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPK
NPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SMNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLF
HGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPK
NPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
;
_entity_poly.pdbx_strand_id                 B,A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'DIMETHYL SULFOXIDE'                                                                                          DMS   
3 '(4S)-2-METHYL-2,4-PENTANEDIOL'                                                                               MPD   
4 '(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' A1H44 
5 water                                                                                                         HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   MET n 
1 3   ASN n 
1 4   LEU n 
1 5   PRO n 
1 6   GLU n 
1 7   HIS n 
1 8   TRP n 
1 9   THR n 
1 10  ASP n 
1 11  MET n 
1 12  ASN n 
1 13  HIS n 
1 14  GLN n 
1 15  LEU n 
1 16  PHE n 
1 17  CYS n 
1 18  MET n 
1 19  VAL n 
1 20  GLN n 
1 21  LEU n 
1 22  GLU n 
1 23  PRO n 
1 24  GLY n 
1 25  GLN n 
1 26  SER n 
1 27  GLU n 
1 28  TYR n 
1 29  ASN n 
1 30  THR n 
1 31  ILE n 
1 32  LYS n 
1 33  ASP n 
1 34  LYS n 
1 35  PHE n 
1 36  THR n 
1 37  ARG n 
1 38  THR n 
1 39  CYS n 
1 40  SER n 
1 41  SER n 
1 42  TYR n 
1 43  ALA n 
1 44  ILE n 
1 45  GLU n 
1 46  LYS n 
1 47  ILE n 
1 48  GLU n 
1 49  ARG n 
1 50  ILE n 
1 51  GLN n 
1 52  ASN n 
1 53  ALA n 
1 54  PHE n 
1 55  LEU n 
1 56  TRP n 
1 57  GLN n 
1 58  SER n 
1 59  TYR n 
1 60  GLN n 
1 61  VAL n 
1 62  LYS n 
1 63  LYS n 
1 64  ARG n 
1 65  GLN n 
1 66  MET n 
1 67  ASP n 
1 68  ILE n 
1 69  LYS n 
1 70  ASN n 
1 71  ASP n 
1 72  HIS n 
1 73  LYS n 
1 74  ASN n 
1 75  ASN n 
1 76  GLU n 
1 77  ARG n 
1 78  LEU n 
1 79  LEU n 
1 80  PHE n 
1 81  HIS n 
1 82  GLY n 
1 83  THR n 
1 84  ASP n 
1 85  ALA n 
1 86  ASP n 
1 87  SER n 
1 88  VAL n 
1 89  PRO n 
1 90  TYR n 
1 91  VAL n 
1 92  ASN n 
1 93  GLN n 
1 94  HIS n 
1 95  GLY n 
1 96  PHE n 
1 97  ASN n 
1 98  ARG n 
1 99  SER n 
1 100 CYS n 
1 101 ALA n 
1 102 GLY n 
1 103 LYS n 
1 104 ASN n 
1 105 ALA n 
1 106 VAL n 
1 107 SER n 
1 108 TYR n 
1 109 GLY n 
1 110 LYS n 
1 111 GLY n 
1 112 THR n 
1 113 TYR n 
1 114 PHE n 
1 115 ALA n 
1 116 VAL n 
1 117 ASP n 
1 118 ALA n 
1 119 SER n 
1 120 TYR n 
1 121 SER n 
1 122 ALA n 
1 123 LYS n 
1 124 ASP n 
1 125 THR n 
1 126 TYR n 
1 127 SER n 
1 128 LYS n 
1 129 PRO n 
1 130 ASP n 
1 131 SER n 
1 132 ASN n 
1 133 GLY n 
1 134 ARG n 
1 135 LYS n 
1 136 HIS n 
1 137 MET n 
1 138 TYR n 
1 139 VAL n 
1 140 VAL n 
1 141 ARG n 
1 142 VAL n 
1 143 LEU n 
1 144 THR n 
1 145 GLY n 
1 146 VAL n 
1 147 PHE n 
1 148 THR n 
1 149 LYS n 
1 150 GLY n 
1 151 ARG n 
1 152 ALA n 
1 153 GLY n 
1 154 LEU n 
1 155 VAL n 
1 156 THR n 
1 157 PRO n 
1 158 PRO n 
1 159 PRO n 
1 160 LYS n 
1 161 ASN n 
1 162 PRO n 
1 163 HIS n 
1 164 ASN n 
1 165 PRO n 
1 166 THR n 
1 167 ASP n 
1 168 LEU n 
1 169 PHE n 
1 170 ASP n 
1 171 SER n 
1 172 VAL n 
1 173 THR n 
1 174 ASN n 
1 175 ASN n 
1 176 THR n 
1 177 ARG n 
1 178 SER n 
1 179 PRO n 
1 180 LYS n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 VAL n 
1 185 PHE n 
1 186 PHE n 
1 187 ASP n 
1 188 ASN n 
1 189 GLN n 
1 190 ALA n 
1 191 TYR n 
1 192 PRO n 
1 193 GLU n 
1 194 TYR n 
1 195 LEU n 
1 196 ILE n 
1 197 THR n 
1 198 PHE n 
1 199 THR n 
1 200 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   200 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PARP15, BAL3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1H44 non-polymer         . 
'(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' ? 'C21 H23 N3 O4'  
381.425 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
DMS   non-polymer         . 'DIMETHYL SULFOXIDE' ? 'C2 H6 O S'      78.133  
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
MPD   non-polymer         . '(4S)-2-METHYL-2,4-PENTANEDIOL' ? 'C6 H14 O2'      118.174 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   479 ?   ?   ?   B . n 
A 1 2   MET 2   480 ?   ?   ?   B . n 
A 1 3   ASN 3   481 481 ASN ASN B . n 
A 1 4   LEU 4   482 482 LEU LEU B . n 
A 1 5   PRO 5   483 483 PRO PRO B . n 
A 1 6   GLU 6   484 484 GLU GLU B . n 
A 1 7   HIS 7   485 485 HIS HIS B . n 
A 1 8   TRP 8   486 486 TRP TRP B . n 
A 1 9   THR 9   487 487 THR THR B . n 
A 1 10  ASP 10  488 488 ASP ASP B . n 
A 1 11  MET 11  489 489 MET MET B . n 
A 1 12  ASN 12  490 490 ASN ASN B . n 
A 1 13  HIS 13  491 491 HIS HIS B . n 
A 1 14  GLN 14  492 492 GLN GLN B . n 
A 1 15  LEU 15  493 493 LEU LEU B . n 
A 1 16  PHE 16  494 494 PHE PHE B . n 
A 1 17  CYS 17  495 495 CYS CYS B . n 
A 1 18  MET 18  496 496 MET MET B . n 
A 1 19  VAL 19  497 497 VAL VAL B . n 
A 1 20  GLN 20  498 498 GLN GLN B . n 
A 1 21  LEU 21  499 499 LEU LEU B . n 
A 1 22  GLU 22  500 500 GLU GLU B . n 
A 1 23  PRO 23  501 501 PRO PRO B . n 
A 1 24  GLY 24  502 502 GLY GLY B . n 
A 1 25  GLN 25  503 503 GLN GLN B . n 
A 1 26  SER 26  504 504 SER SER B . n 
A 1 27  GLU 27  505 505 GLU GLU B . n 
A 1 28  TYR 28  506 506 TYR TYR B . n 
A 1 29  ASN 29  507 507 ASN ASN B . n 
A 1 30  THR 30  508 508 THR THR B . n 
A 1 31  ILE 31  509 509 ILE ILE B . n 
A 1 32  LYS 32  510 510 LYS LYS B . n 
A 1 33  ASP 33  511 511 ASP ASP B . n 
A 1 34  LYS 34  512 512 LYS LYS B . n 
A 1 35  PHE 35  513 513 PHE PHE B . n 
A 1 36  THR 36  514 514 THR THR B . n 
A 1 37  ARG 37  515 515 ARG ARG B . n 
A 1 38  THR 38  516 516 THR THR B . n 
A 1 39  CYS 39  517 517 CYS CYS B . n 
A 1 40  SER 40  518 518 SER SER B . n 
A 1 41  SER 41  519 519 SER SER B . n 
A 1 42  TYR 42  520 520 TYR TYR B . n 
A 1 43  ALA 43  521 521 ALA ALA B . n 
A 1 44  ILE 44  522 522 ILE ILE B . n 
A 1 45  GLU 45  523 523 GLU GLU B . n 
A 1 46  LYS 46  524 524 LYS LYS B . n 
A 1 47  ILE 47  525 525 ILE ILE B . n 
A 1 48  GLU 48  526 526 GLU GLU B . n 
A 1 49  ARG 49  527 527 ARG ARG B . n 
A 1 50  ILE 50  528 528 ILE ILE B . n 
A 1 51  GLN 51  529 529 GLN GLN B . n 
A 1 52  ASN 52  530 530 ASN ASN B . n 
A 1 53  ALA 53  531 531 ALA ALA B . n 
A 1 54  PHE 54  532 532 PHE PHE B . n 
A 1 55  LEU 55  533 533 LEU LEU B . n 
A 1 56  TRP 56  534 534 TRP TRP B . n 
A 1 57  GLN 57  535 535 GLN GLN B . n 
A 1 58  SER 58  536 536 SER SER B . n 
A 1 59  TYR 59  537 537 TYR TYR B . n 
A 1 60  GLN 60  538 538 GLN GLN B . n 
A 1 61  VAL 61  539 539 VAL VAL B . n 
A 1 62  LYS 62  540 540 LYS LYS B . n 
A 1 63  LYS 63  541 541 LYS LYS B . n 
A 1 64  ARG 64  542 542 ARG ARG B . n 
A 1 65  GLN 65  543 543 GLN GLN B . n 
A 1 66  MET 66  544 544 MET MET B . n 
A 1 67  ASP 67  545 545 ASP ASP B . n 
A 1 68  ILE 68  546 546 ILE ILE B . n 
A 1 69  LYS 69  547 547 LYS LYS B . n 
A 1 70  ASN 70  548 548 ASN ASN B . n 
A 1 71  ASP 71  549 549 ASP ASP B . n 
A 1 72  HIS 72  550 550 HIS HIS B . n 
A 1 73  LYS 73  551 551 LYS LYS B . n 
A 1 74  ASN 74  552 552 ASN ASN B . n 
A 1 75  ASN 75  553 553 ASN ASN B . n 
A 1 76  GLU 76  554 554 GLU GLU B . n 
A 1 77  ARG 77  555 555 ARG ARG B . n 
A 1 78  LEU 78  556 556 LEU LEU B . n 
A 1 79  LEU 79  557 557 LEU LEU B . n 
A 1 80  PHE 80  558 558 PHE PHE B . n 
A 1 81  HIS 81  559 559 HIS HIS B . n 
A 1 82  GLY 82  560 560 GLY GLY B . n 
A 1 83  THR 83  561 561 THR THR B . n 
A 1 84  ASP 84  562 562 ASP ASP B . n 
A 1 85  ALA 85  563 563 ALA ALA B . n 
A 1 86  ASP 86  564 564 ASP ASP B . n 
A 1 87  SER 87  565 565 SER SER B . n 
A 1 88  VAL 88  566 566 VAL VAL B . n 
A 1 89  PRO 89  567 567 PRO PRO B . n 
A 1 90  TYR 90  568 568 TYR TYR B . n 
A 1 91  VAL 91  569 569 VAL VAL B . n 
A 1 92  ASN 92  570 570 ASN ASN B . n 
A 1 93  GLN 93  571 571 GLN GLN B . n 
A 1 94  HIS 94  572 572 HIS HIS B . n 
A 1 95  GLY 95  573 573 GLY GLY B . n 
A 1 96  PHE 96  574 574 PHE PHE B . n 
A 1 97  ASN 97  575 575 ASN ASN B . n 
A 1 98  ARG 98  576 576 ARG ARG B . n 
A 1 99  SER 99  577 577 SER SER B . n 
A 1 100 CYS 100 578 578 CYS CYS B . n 
A 1 101 ALA 101 579 579 ALA ALA B . n 
A 1 102 GLY 102 580 580 GLY GLY B . n 
A 1 103 LYS 103 581 581 LYS LYS B . n 
A 1 104 ASN 104 582 582 ASN ASN B . n 
A 1 105 ALA 105 583 583 ALA ALA B . n 
A 1 106 VAL 106 584 584 VAL VAL B . n 
A 1 107 SER 107 585 585 SER SER B . n 
A 1 108 TYR 108 586 586 TYR TYR B . n 
A 1 109 GLY 109 587 587 GLY GLY B . n 
A 1 110 LYS 110 588 588 LYS LYS B . n 
A 1 111 GLY 111 589 589 GLY GLY B . n 
A 1 112 THR 112 590 590 THR THR B . n 
A 1 113 TYR 113 591 591 TYR TYR B . n 
A 1 114 PHE 114 592 592 PHE PHE B . n 
A 1 115 ALA 115 593 593 ALA ALA B . n 
A 1 116 VAL 116 594 594 VAL VAL B . n 
A 1 117 ASP 117 595 595 ASP ASP B . n 
A 1 118 ALA 118 596 596 ALA ALA B . n 
A 1 119 SER 119 597 597 SER SER B . n 
A 1 120 TYR 120 598 598 TYR TYR B . n 
A 1 121 SER 121 599 599 SER SER B . n 
A 1 122 ALA 122 600 600 ALA ALA B . n 
A 1 123 LYS 123 601 601 LYS LYS B . n 
A 1 124 ASP 124 602 602 ASP ASP B . n 
A 1 125 THR 125 603 603 THR THR B . n 
A 1 126 TYR 126 604 604 TYR TYR B . n 
A 1 127 SER 127 605 605 SER SER B . n 
A 1 128 LYS 128 606 606 LYS LYS B . n 
A 1 129 PRO 129 607 607 PRO PRO B . n 
A 1 130 ASP 130 608 608 ASP ASP B . n 
A 1 131 SER 131 609 609 SER SER B . n 
A 1 132 ASN 132 610 610 ASN ASN B . n 
A 1 133 GLY 133 611 611 GLY GLY B . n 
A 1 134 ARG 134 612 612 ARG ARG B . n 
A 1 135 LYS 135 613 613 LYS LYS B . n 
A 1 136 HIS 136 614 614 HIS HIS B . n 
A 1 137 MET 137 615 615 MET MET B . n 
A 1 138 TYR 138 616 616 TYR TYR B . n 
A 1 139 VAL 139 617 617 VAL VAL B . n 
A 1 140 VAL 140 618 618 VAL VAL B . n 
A 1 141 ARG 141 619 619 ARG ARG B . n 
A 1 142 VAL 142 620 620 VAL VAL B . n 
A 1 143 LEU 143 621 621 LEU LEU B . n 
A 1 144 THR 144 622 622 THR THR B . n 
A 1 145 GLY 145 623 623 GLY GLY B . n 
A 1 146 VAL 146 624 624 VAL VAL B . n 
A 1 147 PHE 147 625 625 PHE PHE B . n 
A 1 148 THR 148 626 626 THR THR B . n 
A 1 149 LYS 149 627 627 LYS LYS B . n 
A 1 150 GLY 150 628 628 GLY GLY B . n 
A 1 151 ARG 151 629 629 ARG ARG B . n 
A 1 152 ALA 152 630 630 ALA ALA B . n 
A 1 153 GLY 153 631 631 GLY GLY B . n 
A 1 154 LEU 154 632 632 LEU LEU B . n 
A 1 155 VAL 155 633 633 VAL VAL B . n 
A 1 156 THR 156 634 634 THR THR B . n 
A 1 157 PRO 157 635 635 PRO PRO B . n 
A 1 158 PRO 158 636 636 PRO PRO B . n 
A 1 159 PRO 159 637 637 PRO PRO B . n 
A 1 160 LYS 160 638 638 LYS LYS B . n 
A 1 161 ASN 161 639 639 ASN ASN B . n 
A 1 162 PRO 162 640 640 PRO PRO B . n 
A 1 163 HIS 163 641 641 HIS HIS B . n 
A 1 164 ASN 164 642 642 ASN ASN B . n 
A 1 165 PRO 165 643 643 PRO PRO B . n 
A 1 166 THR 166 644 644 THR THR B . n 
A 1 167 ASP 167 645 645 ASP ASP B . n 
A 1 168 LEU 168 646 646 LEU LEU B . n 
A 1 169 PHE 169 647 647 PHE PHE B . n 
A 1 170 ASP 170 648 648 ASP ASP B . n 
A 1 171 SER 171 649 649 SER SER B . n 
A 1 172 VAL 172 650 650 VAL VAL B . n 
A 1 173 THR 173 651 651 THR THR B . n 
A 1 174 ASN 174 652 652 ASN ASN B . n 
A 1 175 ASN 175 653 653 ASN ASN B . n 
A 1 176 THR 176 654 654 THR THR B . n 
A 1 177 ARG 177 655 655 ARG ARG B . n 
A 1 178 SER 178 656 656 SER SER B . n 
A 1 179 PRO 179 657 657 PRO PRO B . n 
A 1 180 LYS 180 658 658 LYS LYS B . n 
A 1 181 LEU 181 659 659 LEU LEU B . n 
A 1 182 PHE 182 660 660 PHE PHE B . n 
A 1 183 VAL 183 661 661 VAL VAL B . n 
A 1 184 VAL 184 662 662 VAL VAL B . n 
A 1 185 PHE 185 663 663 PHE PHE B . n 
A 1 186 PHE 186 664 664 PHE PHE B . n 
A 1 187 ASP 187 665 665 ASP ASP B . n 
A 1 188 ASN 188 666 666 ASN ASN B . n 
A 1 189 GLN 189 667 667 GLN GLN B . n 
A 1 190 ALA 190 668 668 ALA ALA B . n 
A 1 191 TYR 191 669 669 TYR TYR B . n 
A 1 192 PRO 192 670 670 PRO PRO B . n 
A 1 193 GLU 193 671 671 GLU GLU B . n 
A 1 194 TYR 194 672 672 TYR TYR B . n 
A 1 195 LEU 195 673 673 LEU LEU B . n 
A 1 196 ILE 196 674 674 ILE ILE B . n 
A 1 197 THR 197 675 675 THR THR B . n 
A 1 198 PHE 198 676 676 PHE PHE B . n 
A 1 199 THR 199 677 677 THR THR B . n 
A 1 200 ALA 200 678 678 ALA ALA B . n 
B 1 1   SER 1   479 ?   ?   ?   A . n 
B 1 2   MET 2   480 ?   ?   ?   A . n 
B 1 3   ASN 3   481 481 ASN ASN A . n 
B 1 4   LEU 4   482 482 LEU LEU A . n 
B 1 5   PRO 5   483 483 PRO PRO A . n 
B 1 6   GLU 6   484 484 GLU GLU A . n 
B 1 7   HIS 7   485 485 HIS HIS A . n 
B 1 8   TRP 8   486 486 TRP TRP A . n 
B 1 9   THR 9   487 487 THR THR A . n 
B 1 10  ASP 10  488 488 ASP ASP A . n 
B 1 11  MET 11  489 489 MET MET A . n 
B 1 12  ASN 12  490 490 ASN ASN A . n 
B 1 13  HIS 13  491 491 HIS HIS A . n 
B 1 14  GLN 14  492 492 GLN GLN A . n 
B 1 15  LEU 15  493 493 LEU LEU A . n 
B 1 16  PHE 16  494 494 PHE PHE A . n 
B 1 17  CYS 17  495 495 CYS CYS A . n 
B 1 18  MET 18  496 496 MET MET A . n 
B 1 19  VAL 19  497 497 VAL VAL A . n 
B 1 20  GLN 20  498 498 GLN GLN A . n 
B 1 21  LEU 21  499 499 LEU LEU A . n 
B 1 22  GLU 22  500 500 GLU GLU A . n 
B 1 23  PRO 23  501 501 PRO PRO A . n 
B 1 24  GLY 24  502 502 GLY GLY A . n 
B 1 25  GLN 25  503 503 GLN GLN A . n 
B 1 26  SER 26  504 504 SER SER A . n 
B 1 27  GLU 27  505 505 GLU GLU A . n 
B 1 28  TYR 28  506 506 TYR TYR A . n 
B 1 29  ASN 29  507 507 ASN ASN A . n 
B 1 30  THR 30  508 508 THR THR A . n 
B 1 31  ILE 31  509 509 ILE ILE A . n 
B 1 32  LYS 32  510 510 LYS LYS A . n 
B 1 33  ASP 33  511 511 ASP ASP A . n 
B 1 34  LYS 34  512 512 LYS LYS A . n 
B 1 35  PHE 35  513 513 PHE PHE A . n 
B 1 36  THR 36  514 514 THR THR A . n 
B 1 37  ARG 37  515 515 ARG ARG A . n 
B 1 38  THR 38  516 516 THR THR A . n 
B 1 39  CYS 39  517 517 CYS CYS A . n 
B 1 40  SER 40  518 518 SER SER A . n 
B 1 41  SER 41  519 519 SER SER A . n 
B 1 42  TYR 42  520 520 TYR TYR A . n 
B 1 43  ALA 43  521 521 ALA ALA A . n 
B 1 44  ILE 44  522 522 ILE ILE A . n 
B 1 45  GLU 45  523 523 GLU GLU A . n 
B 1 46  LYS 46  524 524 LYS LYS A . n 
B 1 47  ILE 47  525 525 ILE ILE A . n 
B 1 48  GLU 48  526 526 GLU GLU A . n 
B 1 49  ARG 49  527 527 ARG ARG A . n 
B 1 50  ILE 50  528 528 ILE ILE A . n 
B 1 51  GLN 51  529 529 GLN GLN A . n 
B 1 52  ASN 52  530 530 ASN ASN A . n 
B 1 53  ALA 53  531 531 ALA ALA A . n 
B 1 54  PHE 54  532 532 PHE PHE A . n 
B 1 55  LEU 55  533 533 LEU LEU A . n 
B 1 56  TRP 56  534 534 TRP TRP A . n 
B 1 57  GLN 57  535 535 GLN GLN A . n 
B 1 58  SER 58  536 536 SER SER A . n 
B 1 59  TYR 59  537 537 TYR TYR A . n 
B 1 60  GLN 60  538 538 GLN GLN A . n 
B 1 61  VAL 61  539 539 VAL VAL A . n 
B 1 62  LYS 62  540 540 LYS LYS A . n 
B 1 63  LYS 63  541 541 LYS LYS A . n 
B 1 64  ARG 64  542 542 ARG ARG A . n 
B 1 65  GLN 65  543 543 GLN GLN A . n 
B 1 66  MET 66  544 544 MET MET A . n 
B 1 67  ASP 67  545 545 ASP ASP A . n 
B 1 68  ILE 68  546 546 ILE ILE A . n 
B 1 69  LYS 69  547 547 LYS LYS A . n 
B 1 70  ASN 70  548 548 ASN ASN A . n 
B 1 71  ASP 71  549 549 ASP ASP A . n 
B 1 72  HIS 72  550 550 HIS HIS A . n 
B 1 73  LYS 73  551 551 LYS LYS A . n 
B 1 74  ASN 74  552 552 ASN ASN A . n 
B 1 75  ASN 75  553 553 ASN ASN A . n 
B 1 76  GLU 76  554 554 GLU GLU A . n 
B 1 77  ARG 77  555 555 ARG ARG A . n 
B 1 78  LEU 78  556 556 LEU LEU A . n 
B 1 79  LEU 79  557 557 LEU LEU A . n 
B 1 80  PHE 80  558 558 PHE PHE A . n 
B 1 81  HIS 81  559 559 HIS HIS A . n 
B 1 82  GLY 82  560 560 GLY GLY A . n 
B 1 83  THR 83  561 561 THR THR A . n 
B 1 84  ASP 84  562 562 ASP ASP A . n 
B 1 85  ALA 85  563 563 ALA ALA A . n 
B 1 86  ASP 86  564 564 ASP ASP A . n 
B 1 87  SER 87  565 565 SER SER A . n 
B 1 88  VAL 88  566 566 VAL VAL A . n 
B 1 89  PRO 89  567 567 PRO PRO A . n 
B 1 90  TYR 90  568 568 TYR TYR A . n 
B 1 91  VAL 91  569 569 VAL VAL A . n 
B 1 92  ASN 92  570 570 ASN ASN A . n 
B 1 93  GLN 93  571 571 GLN GLN A . n 
B 1 94  HIS 94  572 572 HIS HIS A . n 
B 1 95  GLY 95  573 573 GLY GLY A . n 
B 1 96  PHE 96  574 574 PHE PHE A . n 
B 1 97  ASN 97  575 575 ASN ASN A . n 
B 1 98  ARG 98  576 576 ARG ARG A . n 
B 1 99  SER 99  577 577 SER SER A . n 
B 1 100 CYS 100 578 578 CYS CYS A . n 
B 1 101 ALA 101 579 579 ALA ALA A . n 
B 1 102 GLY 102 580 ?   ?   ?   A . n 
B 1 103 LYS 103 581 ?   ?   ?   A . n 
B 1 104 ASN 104 582 ?   ?   ?   A . n 
B 1 105 ALA 105 583 583 ALA ALA A . n 
B 1 106 VAL 106 584 584 VAL VAL A . n 
B 1 107 SER 107 585 585 SER SER A . n 
B 1 108 TYR 108 586 586 TYR TYR A . n 
B 1 109 GLY 109 587 587 GLY GLY A . n 
B 1 110 LYS 110 588 588 LYS LYS A . n 
B 1 111 GLY 111 589 589 GLY GLY A . n 
B 1 112 THR 112 590 590 THR THR A . n 
B 1 113 TYR 113 591 591 TYR TYR A . n 
B 1 114 PHE 114 592 592 PHE PHE A . n 
B 1 115 ALA 115 593 593 ALA ALA A . n 
B 1 116 VAL 116 594 594 VAL VAL A . n 
B 1 117 ASP 117 595 595 ASP ASP A . n 
B 1 118 ALA 118 596 596 ALA ALA A . n 
B 1 119 SER 119 597 597 SER SER A . n 
B 1 120 TYR 120 598 598 TYR TYR A . n 
B 1 121 SER 121 599 599 SER SER A . n 
B 1 122 ALA 122 600 600 ALA ALA A . n 
B 1 123 LYS 123 601 601 LYS LYS A . n 
B 1 124 ASP 124 602 602 ASP ASP A . n 
B 1 125 THR 125 603 603 THR THR A . n 
B 1 126 TYR 126 604 604 TYR TYR A . n 
B 1 127 SER 127 605 605 SER SER A . n 
B 1 128 LYS 128 606 606 LYS LYS A . n 
B 1 129 PRO 129 607 607 PRO PRO A . n 
B 1 130 ASP 130 608 608 ASP ASP A . n 
B 1 131 SER 131 609 609 SER SER A . n 
B 1 132 ASN 132 610 610 ASN ASN A . n 
B 1 133 GLY 133 611 611 GLY GLY A . n 
B 1 134 ARG 134 612 612 ARG ARG A . n 
B 1 135 LYS 135 613 613 LYS LYS A . n 
B 1 136 HIS 136 614 614 HIS HIS A . n 
B 1 137 MET 137 615 615 MET MET A . n 
B 1 138 TYR 138 616 616 TYR TYR A . n 
B 1 139 VAL 139 617 617 VAL VAL A . n 
B 1 140 VAL 140 618 618 VAL VAL A . n 
B 1 141 ARG 141 619 619 ARG ARG A . n 
B 1 142 VAL 142 620 620 VAL VAL A . n 
B 1 143 LEU 143 621 621 LEU LEU A . n 
B 1 144 THR 144 622 622 THR THR A . n 
B 1 145 GLY 145 623 623 GLY GLY A . n 
B 1 146 VAL 146 624 624 VAL VAL A . n 
B 1 147 PHE 147 625 625 PHE PHE A . n 
B 1 148 THR 148 626 626 THR THR A . n 
B 1 149 LYS 149 627 627 LYS LYS A . n 
B 1 150 GLY 150 628 628 GLY GLY A . n 
B 1 151 ARG 151 629 629 ARG ARG A . n 
B 1 152 ALA 152 630 630 ALA ALA A . n 
B 1 153 GLY 153 631 631 GLY GLY A . n 
B 1 154 LEU 154 632 632 LEU LEU A . n 
B 1 155 VAL 155 633 633 VAL VAL A . n 
B 1 156 THR 156 634 634 THR THR A . n 
B 1 157 PRO 157 635 635 PRO PRO A . n 
B 1 158 PRO 158 636 636 PRO PRO A . n 
B 1 159 PRO 159 637 637 PRO PRO A . n 
B 1 160 LYS 160 638 638 LYS LYS A . n 
B 1 161 ASN 161 639 639 ASN ASN A . n 
B 1 162 PRO 162 640 640 PRO PRO A . n 
B 1 163 HIS 163 641 641 HIS HIS A . n 
B 1 164 ASN 164 642 642 ASN ASN A . n 
B 1 165 PRO 165 643 643 PRO PRO A . n 
B 1 166 THR 166 644 644 THR THR A . n 
B 1 167 ASP 167 645 645 ASP ASP A . n 
B 1 168 LEU 168 646 646 LEU LEU A . n 
B 1 169 PHE 169 647 647 PHE PHE A . n 
B 1 170 ASP 170 648 648 ASP ASP A . n 
B 1 171 SER 171 649 649 SER SER A . n 
B 1 172 VAL 172 650 650 VAL VAL A . n 
B 1 173 THR 173 651 651 THR THR A . n 
B 1 174 ASN 174 652 652 ASN ASN A . n 
B 1 175 ASN 175 653 653 ASN ASN A . n 
B 1 176 THR 176 654 654 THR THR A . n 
B 1 177 ARG 177 655 655 ARG ARG A . n 
B 1 178 SER 178 656 656 SER SER A . n 
B 1 179 PRO 179 657 657 PRO PRO A . n 
B 1 180 LYS 180 658 658 LYS LYS A . n 
B 1 181 LEU 181 659 659 LEU LEU A . n 
B 1 182 PHE 182 660 660 PHE PHE A . n 
B 1 183 VAL 183 661 661 VAL VAL A . n 
B 1 184 VAL 184 662 662 VAL VAL A . n 
B 1 185 PHE 185 663 663 PHE PHE A . n 
B 1 186 PHE 186 664 664 PHE PHE A . n 
B 1 187 ASP 187 665 665 ASP ASP A . n 
B 1 188 ASN 188 666 666 ASN ASN A . n 
B 1 189 GLN 189 667 667 GLN GLN A . n 
B 1 190 ALA 190 668 668 ALA ALA A . n 
B 1 191 TYR 191 669 669 TYR TYR A . n 
B 1 192 PRO 192 670 670 PRO PRO A . n 
B 1 193 GLU 193 671 671 GLU GLU A . n 
B 1 194 TYR 194 672 672 TYR TYR A . n 
B 1 195 LEU 195 673 673 LEU LEU A . n 
B 1 196 ILE 196 674 674 ILE ILE A . n 
B 1 197 THR 197 675 675 THR THR A . n 
B 1 198 PHE 198 676 676 PHE PHE A . n 
B 1 199 THR 199 677 677 THR THR A . n 
B 1 200 ALA 200 678 678 ALA ALA A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1H44 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1H44 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 DMS   1   701 701 DMS   DMS B . 
D 3 MPD   1   701 702 MPD   MPD A . 
E 4 A1H44 1   702 703 A1H44 365 A . 
F 5 HOH   1   801 69  HOH   HOH B . 
F 5 HOH   2   802 60  HOH   HOH B . 
F 5 HOH   3   803 151 HOH   HOH B . 
F 5 HOH   4   804 131 HOH   HOH B . 
F 5 HOH   5   805 33  HOH   HOH B . 
F 5 HOH   6   806 17  HOH   HOH B . 
F 5 HOH   7   807 70  HOH   HOH B . 
F 5 HOH   8   808 1   HOH   HOH B . 
F 5 HOH   9   809 74  HOH   HOH B . 
F 5 HOH   10  810 96  HOH   HOH B . 
F 5 HOH   11  811 123 HOH   HOH B . 
F 5 HOH   12  812 157 HOH   HOH B . 
F 5 HOH   13  813 82  HOH   HOH B . 
F 5 HOH   14  814 223 HOH   HOH B . 
F 5 HOH   15  815 52  HOH   HOH B . 
F 5 HOH   16  816 162 HOH   HOH B . 
F 5 HOH   17  817 143 HOH   HOH B . 
F 5 HOH   18  818 113 HOH   HOH B . 
F 5 HOH   19  819 171 HOH   HOH B . 
F 5 HOH   20  820 103 HOH   HOH B . 
F 5 HOH   21  821 110 HOH   HOH B . 
F 5 HOH   22  822 164 HOH   HOH B . 
F 5 HOH   23  823 219 HOH   HOH B . 
F 5 HOH   24  824 194 HOH   HOH B . 
F 5 HOH   25  825 16  HOH   HOH B . 
F 5 HOH   26  826 126 HOH   HOH B . 
F 5 HOH   27  827 97  HOH   HOH B . 
F 5 HOH   28  828 203 HOH   HOH B . 
F 5 HOH   29  829 65  HOH   HOH B . 
F 5 HOH   30  830 198 HOH   HOH B . 
F 5 HOH   31  831 145 HOH   HOH B . 
F 5 HOH   32  832 99  HOH   HOH B . 
F 5 HOH   33  833 61  HOH   HOH B . 
F 5 HOH   34  834 156 HOH   HOH B . 
F 5 HOH   35  835 186 HOH   HOH B . 
F 5 HOH   36  836 42  HOH   HOH B . 
F 5 HOH   37  837 13  HOH   HOH B . 
F 5 HOH   38  838 221 HOH   HOH B . 
F 5 HOH   39  839 46  HOH   HOH B . 
F 5 HOH   40  840 7   HOH   HOH B . 
F 5 HOH   41  841 76  HOH   HOH B . 
F 5 HOH   42  842 5   HOH   HOH B . 
F 5 HOH   43  843 51  HOH   HOH B . 
F 5 HOH   44  844 55  HOH   HOH B . 
F 5 HOH   45  845 144 HOH   HOH B . 
F 5 HOH   46  846 222 HOH   HOH B . 
F 5 HOH   47  847 39  HOH   HOH B . 
F 5 HOH   48  848 128 HOH   HOH B . 
F 5 HOH   49  849 90  HOH   HOH B . 
F 5 HOH   50  850 142 HOH   HOH B . 
F 5 HOH   51  851 19  HOH   HOH B . 
F 5 HOH   52  852 197 HOH   HOH B . 
F 5 HOH   53  853 140 HOH   HOH B . 
F 5 HOH   54  854 15  HOH   HOH B . 
F 5 HOH   55  855 129 HOH   HOH B . 
F 5 HOH   56  856 31  HOH   HOH B . 
F 5 HOH   57  857 21  HOH   HOH B . 
F 5 HOH   58  858 187 HOH   HOH B . 
F 5 HOH   59  859 45  HOH   HOH B . 
F 5 HOH   60  860 23  HOH   HOH B . 
F 5 HOH   61  861 6   HOH   HOH B . 
F 5 HOH   62  862 122 HOH   HOH B . 
F 5 HOH   63  863 8   HOH   HOH B . 
F 5 HOH   64  864 38  HOH   HOH B . 
F 5 HOH   65  865 68  HOH   HOH B . 
F 5 HOH   66  866 3   HOH   HOH B . 
F 5 HOH   67  867 92  HOH   HOH B . 
F 5 HOH   68  868 185 HOH   HOH B . 
F 5 HOH   69  869 22  HOH   HOH B . 
F 5 HOH   70  870 85  HOH   HOH B . 
F 5 HOH   71  871 161 HOH   HOH B . 
F 5 HOH   72  872 195 HOH   HOH B . 
F 5 HOH   73  873 130 HOH   HOH B . 
F 5 HOH   74  874 193 HOH   HOH B . 
F 5 HOH   75  875 66  HOH   HOH B . 
F 5 HOH   76  876 217 HOH   HOH B . 
F 5 HOH   77  877 153 HOH   HOH B . 
F 5 HOH   78  878 43  HOH   HOH B . 
F 5 HOH   79  879 200 HOH   HOH B . 
F 5 HOH   80  880 115 HOH   HOH B . 
F 5 HOH   81  881 132 HOH   HOH B . 
F 5 HOH   82  882 94  HOH   HOH B . 
F 5 HOH   83  883 40  HOH   HOH B . 
F 5 HOH   84  884 12  HOH   HOH B . 
F 5 HOH   85  885 89  HOH   HOH B . 
F 5 HOH   86  886 170 HOH   HOH B . 
F 5 HOH   87  887 192 HOH   HOH B . 
F 5 HOH   88  888 50  HOH   HOH B . 
F 5 HOH   89  889 25  HOH   HOH B . 
F 5 HOH   90  890 207 HOH   HOH B . 
F 5 HOH   91  891 73  HOH   HOH B . 
F 5 HOH   92  892 154 HOH   HOH B . 
F 5 HOH   93  893 117 HOH   HOH B . 
F 5 HOH   94  894 127 HOH   HOH B . 
F 5 HOH   95  895 180 HOH   HOH B . 
F 5 HOH   96  896 166 HOH   HOH B . 
F 5 HOH   97  897 118 HOH   HOH B . 
F 5 HOH   98  898 30  HOH   HOH B . 
F 5 HOH   99  899 83  HOH   HOH B . 
F 5 HOH   100 900 137 HOH   HOH B . 
F 5 HOH   101 901 138 HOH   HOH B . 
F 5 HOH   102 902 18  HOH   HOH B . 
F 5 HOH   103 903 165 HOH   HOH B . 
F 5 HOH   104 904 174 HOH   HOH B . 
F 5 HOH   105 905 56  HOH   HOH B . 
F 5 HOH   106 906 93  HOH   HOH B . 
F 5 HOH   107 907 29  HOH   HOH B . 
F 5 HOH   108 908 158 HOH   HOH B . 
F 5 HOH   109 909 190 HOH   HOH B . 
F 5 HOH   110 910 27  HOH   HOH B . 
F 5 HOH   111 911 100 HOH   HOH B . 
F 5 HOH   112 912 58  HOH   HOH B . 
F 5 HOH   113 913 208 HOH   HOH B . 
F 5 HOH   114 914 11  HOH   HOH B . 
F 5 HOH   115 915 14  HOH   HOH B . 
F 5 HOH   116 916 77  HOH   HOH B . 
F 5 HOH   117 917 37  HOH   HOH B . 
F 5 HOH   118 918 175 HOH   HOH B . 
F 5 HOH   119 919 28  HOH   HOH B . 
F 5 HOH   120 920 48  HOH   HOH B . 
F 5 HOH   121 921 215 HOH   HOH B . 
F 5 HOH   122 922 2   HOH   HOH B . 
F 5 HOH   123 923 9   HOH   HOH B . 
F 5 HOH   124 924 109 HOH   HOH B . 
F 5 HOH   125 925 168 HOH   HOH B . 
F 5 HOH   126 926 210 HOH   HOH B . 
F 5 HOH   127 927 146 HOH   HOH B . 
F 5 HOH   128 928 199 HOH   HOH B . 
F 5 HOH   129 929 225 HOH   HOH B . 
G 5 HOH   1   801 169 HOH   HOH A . 
G 5 HOH   2   802 209 HOH   HOH A . 
G 5 HOH   3   803 218 HOH   HOH A . 
G 5 HOH   4   804 155 HOH   HOH A . 
G 5 HOH   5   805 86  HOH   HOH A . 
G 5 HOH   6   806 147 HOH   HOH A . 
G 5 HOH   7   807 75  HOH   HOH A . 
G 5 HOH   8   808 172 HOH   HOH A . 
G 5 HOH   9   809 224 HOH   HOH A . 
G 5 HOH   10  810 204 HOH   HOH A . 
G 5 HOH   11  811 167 HOH   HOH A . 
G 5 HOH   12  812 49  HOH   HOH A . 
G 5 HOH   13  813 24  HOH   HOH A . 
G 5 HOH   14  814 41  HOH   HOH A . 
G 5 HOH   15  815 98  HOH   HOH A . 
G 5 HOH   16  816 47  HOH   HOH A . 
G 5 HOH   17  817 107 HOH   HOH A . 
G 5 HOH   18  818 191 HOH   HOH A . 
G 5 HOH   19  819 79  HOH   HOH A . 
G 5 HOH   20  820 34  HOH   HOH A . 
G 5 HOH   21  821 72  HOH   HOH A . 
G 5 HOH   22  822 80  HOH   HOH A . 
G 5 HOH   23  823 116 HOH   HOH A . 
G 5 HOH   24  824 57  HOH   HOH A . 
G 5 HOH   25  825 54  HOH   HOH A . 
G 5 HOH   26  826 112 HOH   HOH A . 
G 5 HOH   27  827 108 HOH   HOH A . 
G 5 HOH   28  828 201 HOH   HOH A . 
G 5 HOH   29  829 26  HOH   HOH A . 
G 5 HOH   30  830 136 HOH   HOH A . 
G 5 HOH   31  831 44  HOH   HOH A . 
G 5 HOH   32  832 102 HOH   HOH A . 
G 5 HOH   33  833 202 HOH   HOH A . 
G 5 HOH   34  834 182 HOH   HOH A . 
G 5 HOH   35  835 152 HOH   HOH A . 
G 5 HOH   36  836 20  HOH   HOH A . 
G 5 HOH   37  837 91  HOH   HOH A . 
G 5 HOH   38  838 189 HOH   HOH A . 
G 5 HOH   39  839 206 HOH   HOH A . 
G 5 HOH   40  840 181 HOH   HOH A . 
G 5 HOH   41  841 84  HOH   HOH A . 
G 5 HOH   42  842 105 HOH   HOH A . 
G 5 HOH   43  843 121 HOH   HOH A . 
G 5 HOH   44  844 10  HOH   HOH A . 
G 5 HOH   45  845 176 HOH   HOH A . 
G 5 HOH   46  846 148 HOH   HOH A . 
G 5 HOH   47  847 104 HOH   HOH A . 
G 5 HOH   48  848 101 HOH   HOH A . 
G 5 HOH   49  849 4   HOH   HOH A . 
G 5 HOH   50  850 59  HOH   HOH A . 
G 5 HOH   51  851 114 HOH   HOH A . 
G 5 HOH   52  852 36  HOH   HOH A . 
G 5 HOH   53  853 53  HOH   HOH A . 
G 5 HOH   54  854 160 HOH   HOH A . 
G 5 HOH   55  855 183 HOH   HOH A . 
G 5 HOH   56  856 159 HOH   HOH A . 
G 5 HOH   57  857 63  HOH   HOH A . 
G 5 HOH   58  858 212 HOH   HOH A . 
G 5 HOH   59  859 67  HOH   HOH A . 
G 5 HOH   60  860 81  HOH   HOH A . 
G 5 HOH   61  861 106 HOH   HOH A . 
G 5 HOH   62  862 120 HOH   HOH A . 
G 5 HOH   63  863 149 HOH   HOH A . 
G 5 HOH   64  864 133 HOH   HOH A . 
G 5 HOH   65  865 163 HOH   HOH A . 
G 5 HOH   66  866 150 HOH   HOH A . 
G 5 HOH   67  867 32  HOH   HOH A . 
G 5 HOH   68  868 139 HOH   HOH A . 
G 5 HOH   69  869 226 HOH   HOH A . 
G 5 HOH   70  870 88  HOH   HOH A . 
G 5 HOH   71  871 141 HOH   HOH A . 
G 5 HOH   72  872 184 HOH   HOH A . 
G 5 HOH   73  873 87  HOH   HOH A . 
G 5 HOH   74  874 124 HOH   HOH A . 
G 5 HOH   75  875 78  HOH   HOH A . 
G 5 HOH   76  876 135 HOH   HOH A . 
G 5 HOH   77  877 111 HOH   HOH A . 
G 5 HOH   78  878 71  HOH   HOH A . 
G 5 HOH   79  879 35  HOH   HOH A . 
G 5 HOH   80  880 62  HOH   HOH A . 
G 5 HOH   81  881 64  HOH   HOH A . 
G 5 HOH   82  882 95  HOH   HOH A . 
G 5 HOH   83  883 205 HOH   HOH A . 
G 5 HOH   84  884 216 HOH   HOH A . 
G 5 HOH   85  885 125 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B ASN 481 ? CG  ? A ASN 3  CG  
2  1 Y 1 B ASN 481 ? OD1 ? A ASN 3  OD1 
3  1 Y 1 B ASN 481 ? ND2 ? A ASN 3  ND2 
4  1 Y 1 A ASN 481 ? CG  ? B ASN 3  CG  
5  1 Y 1 A ASN 481 ? OD1 ? B ASN 3  OD1 
6  1 Y 1 A ASN 481 ? ND2 ? B ASN 3  ND2 
7  1 Y 1 A GLU 484 ? CG  ? B GLU 6  CG  
8  1 Y 1 A GLU 484 ? CD  ? B GLU 6  CD  
9  1 Y 1 A GLU 484 ? OE1 ? B GLU 6  OE1 
10 1 Y 1 A GLU 484 ? OE2 ? B GLU 6  OE2 
11 1 Y 1 A ASP 549 ? CG  ? B ASP 71 CG  
12 1 Y 1 A ASP 549 ? OD1 ? B ASP 71 OD1 
13 1 Y 1 A ASP 549 ? OD2 ? B ASP 71 OD2 
14 1 Y 1 A HIS 550 ? CG  ? B HIS 72 CG  
15 1 Y 1 A HIS 550 ? ND1 ? B HIS 72 ND1 
16 1 Y 1 A HIS 550 ? CD2 ? B HIS 72 CD2 
17 1 Y 1 A HIS 550 ? CE1 ? B HIS 72 CE1 
18 1 Y 1 A HIS 550 ? NE2 ? B HIS 72 NE2 
19 1 Y 1 A LYS 551 ? CG  ? B LYS 73 CG  
20 1 Y 1 A LYS 551 ? CD  ? B LYS 73 CD  
21 1 Y 1 A LYS 551 ? CE  ? B LYS 73 CE  
22 1 Y 1 A LYS 551 ? NZ  ? B LYS 73 NZ  
23 1 Y 1 A ASN 552 ? CG  ? B ASN 74 CG  
24 1 Y 1 A ASN 552 ? OD1 ? B ASN 74 OD1 
25 1 Y 1 A ASN 552 ? ND2 ? B ASN 74 ND2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FEG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.263 
_cell.length_a_esd                 ? 
_cell.length_b                     68.460 
_cell.length_b_esd                 ? 
_cell.length_c                     159.596 
_cell.length_c_esd                 ? 
_cell.volume                       494540.920 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FEG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FEG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.69 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.30 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Growth solution: 200 mM NH4Cl, 20 % PEG3350
Cryo solution:  200 mM NH4Cl, 30 % MPD.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97950 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I24' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97950 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I24 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          19.54 
_reflns.entry_id                                       9FEG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     50967 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.53 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.51 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.86 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             8073 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.787 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               23.00 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FEG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             43.55 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     50963 
_refine.ls_number_reflns_R_free                  2548 
_refine.ls_number_reflns_R_work                  48415 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1836 
_refine.ls_R_factor_R_free                       0.2127 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1820 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.2719 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2212 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        43.55 
_refine_hist.number_atoms_solvent             214 
_refine_hist.number_atoms_total               3416 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3162 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         40 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0104  ? 3364 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8470  ? 4578 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0554  ? 479  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0090  ? 598  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.5993 ? 1235 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.78  . . 136 2605 99.78  . . . . 0.2733 . . . . . . . . . . . 0.2811 
'X-RAY DIFFRACTION' 1.78 1.82  . . 141 2670 100.00 . . . . 0.2573 . . . . . . . . . . . 0.3148 
'X-RAY DIFFRACTION' 1.82 1.86  . . 139 2642 100.00 . . . . 0.2447 . . . . . . . . . . . 0.2500 
'X-RAY DIFFRACTION' 1.86 1.90  . . 141 2672 99.96  . . . . 0.2239 . . . . . . . . . . . 0.2831 
'X-RAY DIFFRACTION' 1.90 1.95  . . 139 2648 99.96  . . . . 0.2122 . . . . . . . . . . . 0.2613 
'X-RAY DIFFRACTION' 1.95 2.00  . . 139 2641 100.00 . . . . 0.1957 . . . . . . . . . . . 0.2354 
'X-RAY DIFFRACTION' 2.00 2.06  . . 142 2691 99.96  . . . . 0.1973 . . . . . . . . . . . 0.2291 
'X-RAY DIFFRACTION' 2.06 2.13  . . 138 2630 99.96  . . . . 0.1982 . . . . . . . . . . . 0.2221 
'X-RAY DIFFRACTION' 2.13 2.20  . . 140 2668 100.00 . . . . 0.1926 . . . . . . . . . . . 0.2670 
'X-RAY DIFFRACTION' 2.20 2.29  . . 141 2676 99.96  . . . . 0.1767 . . . . . . . . . . . 0.2046 
'X-RAY DIFFRACTION' 2.29 2.40  . . 141 2663 99.93  . . . . 0.1826 . . . . . . . . . . . 0.2152 
'X-RAY DIFFRACTION' 2.40 2.52  . . 142 2710 100.00 . . . . 0.1773 . . . . . . . . . . . 0.1876 
'X-RAY DIFFRACTION' 2.52 2.68  . . 141 2682 100.00 . . . . 0.1787 . . . . . . . . . . . 0.2340 
'X-RAY DIFFRACTION' 2.68 2.89  . . 142 2693 100.00 . . . . 0.1774 . . . . . . . . . . . 0.2152 
'X-RAY DIFFRACTION' 2.89 3.18  . . 143 2710 100.00 . . . . 0.1826 . . . . . . . . . . . 0.2164 
'X-RAY DIFFRACTION' 3.18 3.64  . . 144 2737 99.97  . . . . 0.1727 . . . . . . . . . . . 0.2137 
'X-RAY DIFFRACTION' 3.64 4.58  . . 146 2782 99.97  . . . . 0.1456 . . . . . . . . . . . 0.1538 
'X-RAY DIFFRACTION' 4.58 43.55 . . 153 2895 99.74  . . . . 0.1728 . . . . . . . . . . . 0.1937 
# 
_struct.entry_id                     9FEG 
_struct.title                        'PARP15 in complex with a quinazolin-4-one inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FEG 
_struct_keywords.text            'Inhibitor, Transferase, PARP15, ARTD7' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PAR15_HUMAN 
_struct_ref.pdbx_db_accession          Q460N3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHG
TDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNP
HNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
;
_struct_ref.pdbx_align_begin           481 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9FEG B 3 ? 200 ? Q460N3 481 ? 678 ? 481 678 
2 1 9FEG A 3 ? 200 ? Q460N3 481 ? 678 ? 481 678 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9FEG SER B 1 ? UNP Q460N3 ? ? 'expression tag' 479 1 
1 9FEG MET B 2 ? UNP Q460N3 ? ? 'expression tag' 480 2 
2 9FEG SER A 1 ? UNP Q460N3 ? ? 'expression tag' 479 3 
2 9FEG MET A 2 ? UNP Q460N3 ? ? 'expression tag' 480 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2740  ? 
1 MORE         -21   ? 
1 'SSA (A^2)'  18710 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 25  ? ARG A 37  ? GLN B 503 ARG B 515 1 ? 13 
HELX_P HELX_P2  AA2 ALA A 53  ? ASN A 70  ? ALA B 531 ASN B 548 1 ? 18 
HELX_P HELX_P3  AA3 ASP A 84  ? ASP A 86  ? ASP B 562 ASP B 564 5 ? 3  
HELX_P HELX_P4  AA4 SER A 87  ? GLY A 95  ? SER B 565 GLY B 573 1 ? 9  
HELX_P HELX_P5  AA5 ASN A 97  ? ALA A 101 ? ASN B 575 ALA B 579 5 ? 5  
HELX_P HELX_P6  AA6 ASP A 117 ? ALA A 122 ? ASP B 595 ALA B 600 1 ? 6  
HELX_P HELX_P7  AA7 GLN B 25  ? SER B 40  ? GLN A 503 SER A 518 1 ? 16 
HELX_P HELX_P8  AA8 ALA B 53  ? ASN B 70  ? ALA A 531 ASN A 548 1 ? 18 
HELX_P HELX_P9  AA9 ASP B 84  ? ASP B 86  ? ASP A 562 ASP A 564 5 ? 3  
HELX_P HELX_P10 AB1 SER B 87  ? GLY B 95  ? SER A 565 GLY A 573 1 ? 9  
HELX_P HELX_P11 AB2 ASN B 97  ? ALA B 101 ? ASN A 575 ALA A 579 5 ? 5  
HELX_P HELX_P12 AB3 ASP B 117 ? ALA B 122 ? ASP A 595 ALA A 600 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 4 ? 
AA3 ? 5 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 16  ? GLN A 20  ? PHE B 494 GLN B 498 
AA1 2 ALA A 43  ? ASN A 52  ? ALA B 521 ASN B 530 
AA1 3 ALA A 190 ? THR A 199 ? ALA B 668 THR B 677 
AA1 4 LYS A 135 ? LEU A 143 ? LYS B 613 LEU B 621 
AA1 5 GLU A 76  ? THR A 83  ? GLU B 554 THR B 561 
AA2 1 THR A 112 ? ALA A 115 ? THR B 590 ALA B 593 
AA2 2 LEU A 181 ? VAL A 184 ? LEU B 659 VAL B 662 
AA2 3 SER A 171 ? THR A 173 ? SER B 649 THR B 651 
AA2 4 PHE A 147 ? LYS A 149 ? PHE B 625 LYS B 627 
AA3 1 PHE B 16  ? GLN B 20  ? PHE A 494 GLN A 498 
AA3 2 ALA B 43  ? ASN B 52  ? ALA A 521 ASN A 530 
AA3 3 ALA B 190 ? THR B 199 ? ALA A 668 THR A 677 
AA3 4 LYS B 135 ? LEU B 143 ? LYS A 613 LEU A 621 
AA3 5 GLU B 76  ? THR B 83  ? GLU A 554 THR A 561 
AA4 1 THR B 112 ? ALA B 115 ? THR A 590 ALA A 593 
AA4 2 LEU B 181 ? VAL B 184 ? LEU A 659 VAL A 662 
AA4 3 SER B 171 ? THR B 173 ? SER A 649 THR A 651 
AA4 4 PHE B 147 ? LYS B 149 ? PHE A 625 LYS A 627 
AA5 1 PRO B 159 ? ASN B 161 ? PRO A 637 ASN A 639 
AA5 2 ASN B 164 ? LEU B 168 ? ASN A 642 LEU A 646 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 19  ? N VAL B 497 O ARG A 49  ? O ARG B 527 
AA1 2 3 N ILE A 50  ? N ILE B 528 O GLU A 193 ? O GLU B 671 
AA1 3 4 O PHE A 198 ? O PHE B 676 N LYS A 135 ? N LYS B 613 
AA1 4 5 O VAL A 140 ? O VAL B 618 N LEU A 79  ? N LEU B 557 
AA2 1 2 N PHE A 114 ? N PHE B 592 O PHE A 182 ? O PHE B 660 
AA2 2 3 O VAL A 183 ? O VAL B 661 N VAL A 172 ? N VAL B 650 
AA2 3 4 O THR A 173 ? O THR B 651 N THR A 148 ? N THR B 626 
AA3 1 2 N VAL B 19  ? N VAL A 497 O ARG B 49  ? O ARG A 527 
AA3 2 3 N GLU B 45  ? N GLU A 523 O THR B 197 ? O THR A 675 
AA3 3 4 O ILE B 196 ? O ILE A 674 N MET B 137 ? N MET A 615 
AA3 4 5 O TYR B 138 ? O TYR A 616 N HIS B 81  ? N HIS A 559 
AA4 1 2 N PHE B 114 ? N PHE A 592 O PHE B 182 ? O PHE A 660 
AA4 2 3 O VAL B 183 ? O VAL A 661 N VAL B 172 ? N VAL A 650 
AA4 3 4 O THR B 173 ? O THR A 651 N THR B 148 ? N THR A 626 
AA5 1 2 N LYS B 160 ? N LYS A 638 O ASP B 167 ? O ASP A 645 
# 
_pdbx_entry_details.entry_id                   9FEG 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS B 491 ? ? 69.77   -2.25  
2 1 ASN B 552 ? ? -68.91  98.07  
3 1 TYR B 604 ? ? -101.37 -64.55 
4 1 TYR B 604 ? ? -103.80 -64.55 
5 1 ASN B 653 ? ? -165.25 114.30 
6 1 VAL A 584 ? ? -145.15 42.50  
7 1 TYR A 604 ? ? -105.73 -68.66 
8 1 ASN A 653 ? ? -160.42 112.13 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 B SER 479 ? A SER 1   
2 1 Y 1 B MET 480 ? A MET 2   
3 1 Y 1 A SER 479 ? B SER 1   
4 1 Y 1 A MET 480 ? B MET 2   
5 1 Y 1 A GLY 580 ? B GLY 102 
6 1 Y 1 A LYS 581 ? B LYS 103 
7 1 Y 1 A ASN 582 ? B ASN 104 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1H44 C10  C N N 1   
A1H44 C11  C Y N 2   
A1H44 C14  C Y N 3   
A1H44 C15  C Y N 4   
A1H44 C16  C Y N 5   
A1H44 C17  C Y N 6   
A1H44 C20  C N N 7   
A1H44 C21  C N N 8   
A1H44 C22  C N N 9   
A1H44 C01  C Y N 10  
A1H44 C02  C Y N 11  
A1H44 C03  C Y N 12  
A1H44 C04  C Y N 13  
A1H44 C05  C Y N 14  
A1H44 C06  C Y N 15  
A1H44 C08  C N N 16  
A1H44 C18  C Y N 17  
A1H44 C19  C N N 18  
A1H44 C23  C N N 19  
A1H44 C25  C N R 20  
A1H44 C26  C N N 21  
A1H44 N07  N N N 22  
A1H44 N09  N N N 23  
A1H44 N13  N N N 24  
A1H44 O12  O N N 25  
A1H44 O24  O N N 26  
A1H44 O27  O N N 27  
A1H44 O28  O N N 28  
A1H44 H141 H N N 29  
A1H44 H151 H N N 30  
A1H44 H171 H N N 31  
A1H44 H202 H N N 32  
A1H44 H201 H N N 33  
A1H44 H203 H N N 34  
A1H44 H211 H N N 35  
A1H44 H212 H N N 36  
A1H44 H213 H N N 37  
A1H44 H223 H N N 38  
A1H44 H222 H N N 39  
A1H44 H221 H N N 40  
A1H44 H011 H N N 41  
A1H44 H021 H N N 42  
A1H44 H031 H N N 43  
A1H44 H181 H N N 44  
A1H44 H251 H N N 45  
A1H44 H261 H N N 46  
A1H44 H262 H N N 47  
A1H44 H091 H N N 48  
A1H44 H131 H N N 49  
A1H44 H271 H N N 50  
A1H44 H281 H N N 51  
ALA   N    N N N 52  
ALA   CA   C N S 53  
ALA   C    C N N 54  
ALA   O    O N N 55  
ALA   CB   C N N 56  
ALA   OXT  O N N 57  
ALA   H    H N N 58  
ALA   H2   H N N 59  
ALA   HA   H N N 60  
ALA   HB1  H N N 61  
ALA   HB2  H N N 62  
ALA   HB3  H N N 63  
ALA   HXT  H N N 64  
ARG   N    N N N 65  
ARG   CA   C N S 66  
ARG   C    C N N 67  
ARG   O    O N N 68  
ARG   CB   C N N 69  
ARG   CG   C N N 70  
ARG   CD   C N N 71  
ARG   NE   N N N 72  
ARG   CZ   C N N 73  
ARG   NH1  N N N 74  
ARG   NH2  N N N 75  
ARG   OXT  O N N 76  
ARG   H    H N N 77  
ARG   H2   H N N 78  
ARG   HA   H N N 79  
ARG   HB2  H N N 80  
ARG   HB3  H N N 81  
ARG   HG2  H N N 82  
ARG   HG3  H N N 83  
ARG   HD2  H N N 84  
ARG   HD3  H N N 85  
ARG   HE   H N N 86  
ARG   HH11 H N N 87  
ARG   HH12 H N N 88  
ARG   HH21 H N N 89  
ARG   HH22 H N N 90  
ARG   HXT  H N N 91  
ASN   N    N N N 92  
ASN   CA   C N S 93  
ASN   C    C N N 94  
ASN   O    O N N 95  
ASN   CB   C N N 96  
ASN   CG   C N N 97  
ASN   OD1  O N N 98  
ASN   ND2  N N N 99  
ASN   OXT  O N N 100 
ASN   H    H N N 101 
ASN   H2   H N N 102 
ASN   HA   H N N 103 
ASN   HB2  H N N 104 
ASN   HB3  H N N 105 
ASN   HD21 H N N 106 
ASN   HD22 H N N 107 
ASN   HXT  H N N 108 
ASP   N    N N N 109 
ASP   CA   C N S 110 
ASP   C    C N N 111 
ASP   O    O N N 112 
ASP   CB   C N N 113 
ASP   CG   C N N 114 
ASP   OD1  O N N 115 
ASP   OD2  O N N 116 
ASP   OXT  O N N 117 
ASP   H    H N N 118 
ASP   H2   H N N 119 
ASP   HA   H N N 120 
ASP   HB2  H N N 121 
ASP   HB3  H N N 122 
ASP   HD2  H N N 123 
ASP   HXT  H N N 124 
CYS   N    N N N 125 
CYS   CA   C N R 126 
CYS   C    C N N 127 
CYS   O    O N N 128 
CYS   CB   C N N 129 
CYS   SG   S N N 130 
CYS   OXT  O N N 131 
CYS   H    H N N 132 
CYS   H2   H N N 133 
CYS   HA   H N N 134 
CYS   HB2  H N N 135 
CYS   HB3  H N N 136 
CYS   HG   H N N 137 
CYS   HXT  H N N 138 
DMS   S    S N N 139 
DMS   O    O N N 140 
DMS   C1   C N N 141 
DMS   C2   C N N 142 
DMS   H11  H N N 143 
DMS   H12  H N N 144 
DMS   H13  H N N 145 
DMS   H21  H N N 146 
DMS   H22  H N N 147 
DMS   H23  H N N 148 
GLN   N    N N N 149 
GLN   CA   C N S 150 
GLN   C    C N N 151 
GLN   O    O N N 152 
GLN   CB   C N N 153 
GLN   CG   C N N 154 
GLN   CD   C N N 155 
GLN   OE1  O N N 156 
GLN   NE2  N N N 157 
GLN   OXT  O N N 158 
GLN   H    H N N 159 
GLN   H2   H N N 160 
GLN   HA   H N N 161 
GLN   HB2  H N N 162 
GLN   HB3  H N N 163 
GLN   HG2  H N N 164 
GLN   HG3  H N N 165 
GLN   HE21 H N N 166 
GLN   HE22 H N N 167 
GLN   HXT  H N N 168 
GLU   N    N N N 169 
GLU   CA   C N S 170 
GLU   C    C N N 171 
GLU   O    O N N 172 
GLU   CB   C N N 173 
GLU   CG   C N N 174 
GLU   CD   C N N 175 
GLU   OE1  O N N 176 
GLU   OE2  O N N 177 
GLU   OXT  O N N 178 
GLU   H    H N N 179 
GLU   H2   H N N 180 
GLU   HA   H N N 181 
GLU   HB2  H N N 182 
GLU   HB3  H N N 183 
GLU   HG2  H N N 184 
GLU   HG3  H N N 185 
GLU   HE2  H N N 186 
GLU   HXT  H N N 187 
GLY   N    N N N 188 
GLY   CA   C N N 189 
GLY   C    C N N 190 
GLY   O    O N N 191 
GLY   OXT  O N N 192 
GLY   H    H N N 193 
GLY   H2   H N N 194 
GLY   HA2  H N N 195 
GLY   HA3  H N N 196 
GLY   HXT  H N N 197 
HIS   N    N N N 198 
HIS   CA   C N S 199 
HIS   C    C N N 200 
HIS   O    O N N 201 
HIS   CB   C N N 202 
HIS   CG   C Y N 203 
HIS   ND1  N Y N 204 
HIS   CD2  C Y N 205 
HIS   CE1  C Y N 206 
HIS   NE2  N Y N 207 
HIS   OXT  O N N 208 
HIS   H    H N N 209 
HIS   H2   H N N 210 
HIS   HA   H N N 211 
HIS   HB2  H N N 212 
HIS   HB3  H N N 213 
HIS   HD1  H N N 214 
HIS   HD2  H N N 215 
HIS   HE1  H N N 216 
HIS   HE2  H N N 217 
HIS   HXT  H N N 218 
HOH   O    O N N 219 
HOH   H1   H N N 220 
HOH   H2   H N N 221 
ILE   N    N N N 222 
ILE   CA   C N S 223 
ILE   C    C N N 224 
ILE   O    O N N 225 
ILE   CB   C N S 226 
ILE   CG1  C N N 227 
ILE   CG2  C N N 228 
ILE   CD1  C N N 229 
ILE   OXT  O N N 230 
ILE   H    H N N 231 
ILE   H2   H N N 232 
ILE   HA   H N N 233 
ILE   HB   H N N 234 
ILE   HG12 H N N 235 
ILE   HG13 H N N 236 
ILE   HG21 H N N 237 
ILE   HG22 H N N 238 
ILE   HG23 H N N 239 
ILE   HD11 H N N 240 
ILE   HD12 H N N 241 
ILE   HD13 H N N 242 
ILE   HXT  H N N 243 
LEU   N    N N N 244 
LEU   CA   C N S 245 
LEU   C    C N N 246 
LEU   O    O N N 247 
LEU   CB   C N N 248 
LEU   CG   C N N 249 
LEU   CD1  C N N 250 
LEU   CD2  C N N 251 
LEU   OXT  O N N 252 
LEU   H    H N N 253 
LEU   H2   H N N 254 
LEU   HA   H N N 255 
LEU   HB2  H N N 256 
LEU   HB3  H N N 257 
LEU   HG   H N N 258 
LEU   HD11 H N N 259 
LEU   HD12 H N N 260 
LEU   HD13 H N N 261 
LEU   HD21 H N N 262 
LEU   HD22 H N N 263 
LEU   HD23 H N N 264 
LEU   HXT  H N N 265 
LYS   N    N N N 266 
LYS   CA   C N S 267 
LYS   C    C N N 268 
LYS   O    O N N 269 
LYS   CB   C N N 270 
LYS   CG   C N N 271 
LYS   CD   C N N 272 
LYS   CE   C N N 273 
LYS   NZ   N N N 274 
LYS   OXT  O N N 275 
LYS   H    H N N 276 
LYS   H2   H N N 277 
LYS   HA   H N N 278 
LYS   HB2  H N N 279 
LYS   HB3  H N N 280 
LYS   HG2  H N N 281 
LYS   HG3  H N N 282 
LYS   HD2  H N N 283 
LYS   HD3  H N N 284 
LYS   HE2  H N N 285 
LYS   HE3  H N N 286 
LYS   HZ1  H N N 287 
LYS   HZ2  H N N 288 
LYS   HZ3  H N N 289 
LYS   HXT  H N N 290 
MET   N    N N N 291 
MET   CA   C N S 292 
MET   C    C N N 293 
MET   O    O N N 294 
MET   CB   C N N 295 
MET   CG   C N N 296 
MET   SD   S N N 297 
MET   CE   C N N 298 
MET   OXT  O N N 299 
MET   H    H N N 300 
MET   H2   H N N 301 
MET   HA   H N N 302 
MET   HB2  H N N 303 
MET   HB3  H N N 304 
MET   HG2  H N N 305 
MET   HG3  H N N 306 
MET   HE1  H N N 307 
MET   HE2  H N N 308 
MET   HE3  H N N 309 
MET   HXT  H N N 310 
MPD   C1   C N N 311 
MPD   C2   C N N 312 
MPD   O2   O N N 313 
MPD   CM   C N N 314 
MPD   C3   C N N 315 
MPD   C4   C N S 316 
MPD   O4   O N N 317 
MPD   C5   C N N 318 
MPD   H11  H N N 319 
MPD   H12  H N N 320 
MPD   H13  H N N 321 
MPD   HO2  H N N 322 
MPD   HM1  H N N 323 
MPD   HM2  H N N 324 
MPD   HM3  H N N 325 
MPD   H31  H N N 326 
MPD   H32  H N N 327 
MPD   H4   H N N 328 
MPD   HO4  H N N 329 
MPD   H51  H N N 330 
MPD   H52  H N N 331 
MPD   H53  H N N 332 
PHE   N    N N N 333 
PHE   CA   C N S 334 
PHE   C    C N N 335 
PHE   O    O N N 336 
PHE   CB   C N N 337 
PHE   CG   C Y N 338 
PHE   CD1  C Y N 339 
PHE   CD2  C Y N 340 
PHE   CE1  C Y N 341 
PHE   CE2  C Y N 342 
PHE   CZ   C Y N 343 
PHE   OXT  O N N 344 
PHE   H    H N N 345 
PHE   H2   H N N 346 
PHE   HA   H N N 347 
PHE   HB2  H N N 348 
PHE   HB3  H N N 349 
PHE   HD1  H N N 350 
PHE   HD2  H N N 351 
PHE   HE1  H N N 352 
PHE   HE2  H N N 353 
PHE   HZ   H N N 354 
PHE   HXT  H N N 355 
PRO   N    N N N 356 
PRO   CA   C N S 357 
PRO   C    C N N 358 
PRO   O    O N N 359 
PRO   CB   C N N 360 
PRO   CG   C N N 361 
PRO   CD   C N N 362 
PRO   OXT  O N N 363 
PRO   H    H N N 364 
PRO   HA   H N N 365 
PRO   HB2  H N N 366 
PRO   HB3  H N N 367 
PRO   HG2  H N N 368 
PRO   HG3  H N N 369 
PRO   HD2  H N N 370 
PRO   HD3  H N N 371 
PRO   HXT  H N N 372 
SER   N    N N N 373 
SER   CA   C N S 374 
SER   C    C N N 375 
SER   O    O N N 376 
SER   CB   C N N 377 
SER   OG   O N N 378 
SER   OXT  O N N 379 
SER   H    H N N 380 
SER   H2   H N N 381 
SER   HA   H N N 382 
SER   HB2  H N N 383 
SER   HB3  H N N 384 
SER   HG   H N N 385 
SER   HXT  H N N 386 
THR   N    N N N 387 
THR   CA   C N S 388 
THR   C    C N N 389 
THR   O    O N N 390 
THR   CB   C N R 391 
THR   OG1  O N N 392 
THR   CG2  C N N 393 
THR   OXT  O N N 394 
THR   H    H N N 395 
THR   H2   H N N 396 
THR   HA   H N N 397 
THR   HB   H N N 398 
THR   HG1  H N N 399 
THR   HG21 H N N 400 
THR   HG22 H N N 401 
THR   HG23 H N N 402 
THR   HXT  H N N 403 
TRP   N    N N N 404 
TRP   CA   C N S 405 
TRP   C    C N N 406 
TRP   O    O N N 407 
TRP   CB   C N N 408 
TRP   CG   C Y N 409 
TRP   CD1  C Y N 410 
TRP   CD2  C Y N 411 
TRP   NE1  N Y N 412 
TRP   CE2  C Y N 413 
TRP   CE3  C Y N 414 
TRP   CZ2  C Y N 415 
TRP   CZ3  C Y N 416 
TRP   CH2  C Y N 417 
TRP   OXT  O N N 418 
TRP   H    H N N 419 
TRP   H2   H N N 420 
TRP   HA   H N N 421 
TRP   HB2  H N N 422 
TRP   HB3  H N N 423 
TRP   HD1  H N N 424 
TRP   HE1  H N N 425 
TRP   HE3  H N N 426 
TRP   HZ2  H N N 427 
TRP   HZ3  H N N 428 
TRP   HH2  H N N 429 
TRP   HXT  H N N 430 
TYR   N    N N N 431 
TYR   CA   C N S 432 
TYR   C    C N N 433 
TYR   O    O N N 434 
TYR   CB   C N N 435 
TYR   CG   C Y N 436 
TYR   CD1  C Y N 437 
TYR   CD2  C Y N 438 
TYR   CE1  C Y N 439 
TYR   CE2  C Y N 440 
TYR   CZ   C Y N 441 
TYR   OH   O N N 442 
TYR   OXT  O N N 443 
TYR   H    H N N 444 
TYR   H2   H N N 445 
TYR   HA   H N N 446 
TYR   HB2  H N N 447 
TYR   HB3  H N N 448 
TYR   HD1  H N N 449 
TYR   HD2  H N N 450 
TYR   HE1  H N N 451 
TYR   HE2  H N N 452 
TYR   HH   H N N 453 
TYR   HXT  H N N 454 
VAL   N    N N N 455 
VAL   CA   C N S 456 
VAL   C    C N N 457 
VAL   O    O N N 458 
VAL   CB   C N N 459 
VAL   CG1  C N N 460 
VAL   CG2  C N N 461 
VAL   OXT  O N N 462 
VAL   H    H N N 463 
VAL   H2   H N N 464 
VAL   HA   H N N 465 
VAL   HB   H N N 466 
VAL   HG11 H N N 467 
VAL   HG12 H N N 468 
VAL   HG13 H N N 469 
VAL   HG21 H N N 470 
VAL   HG22 H N N 471 
VAL   HG23 H N N 472 
VAL   HXT  H N N 473 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1H44 C01 C02  doub Y N 1   
A1H44 C01 C06  sing Y N 2   
A1H44 C02 C03  sing Y N 3   
A1H44 C03 C04  doub Y N 4   
A1H44 C04 C05  sing Y N 5   
A1H44 C05 C06  doub Y N 6   
A1H44 N07 C08  doub N N 7   
A1H44 C08 N09  sing N N 8   
A1H44 N09 C10  sing N N 9   
A1H44 C05 N07  sing N N 10  
A1H44 C06 C10  sing N N 11  
A1H44 C08 C11  sing N N 12  
A1H44 C10 O12  doub N N 13  
A1H44 C04 N13  sing N N 14  
A1H44 C14 C15  doub Y N 15  
A1H44 C15 C16  sing Y N 16  
A1H44 C16 C17  doub Y N 17  
A1H44 C17 C18  sing Y N 18  
A1H44 C11 C14  sing Y N 19  
A1H44 C11 C18  doub Y N 20  
A1H44 C16 C19  sing N N 21  
A1H44 C19 C20  sing N N 22  
A1H44 C19 C21  sing N N 23  
A1H44 C19 C22  sing N N 24  
A1H44 N13 C23  sing N N 25  
A1H44 C23 O24  doub N N 26  
A1H44 C25 C23  sing N N 27  
A1H44 C25 C26  sing N N 28  
A1H44 C26 O27  sing N N 29  
A1H44 C25 O28  sing N N 30  
A1H44 C14 H141 sing N N 31  
A1H44 C15 H151 sing N N 32  
A1H44 C17 H171 sing N N 33  
A1H44 C20 H202 sing N N 34  
A1H44 C20 H201 sing N N 35  
A1H44 C20 H203 sing N N 36  
A1H44 C21 H211 sing N N 37  
A1H44 C21 H212 sing N N 38  
A1H44 C21 H213 sing N N 39  
A1H44 C22 H223 sing N N 40  
A1H44 C22 H222 sing N N 41  
A1H44 C22 H221 sing N N 42  
A1H44 C01 H011 sing N N 43  
A1H44 C02 H021 sing N N 44  
A1H44 C03 H031 sing N N 45  
A1H44 C18 H181 sing N N 46  
A1H44 C25 H251 sing N N 47  
A1H44 C26 H261 sing N N 48  
A1H44 C26 H262 sing N N 49  
A1H44 N09 H091 sing N N 50  
A1H44 N13 H131 sing N N 51  
A1H44 O27 H271 sing N N 52  
A1H44 O28 H281 sing N N 53  
ALA   N   CA   sing N N 54  
ALA   N   H    sing N N 55  
ALA   N   H2   sing N N 56  
ALA   CA  C    sing N N 57  
ALA   CA  CB   sing N N 58  
ALA   CA  HA   sing N N 59  
ALA   C   O    doub N N 60  
ALA   C   OXT  sing N N 61  
ALA   CB  HB1  sing N N 62  
ALA   CB  HB2  sing N N 63  
ALA   CB  HB3  sing N N 64  
ALA   OXT HXT  sing N N 65  
ARG   N   CA   sing N N 66  
ARG   N   H    sing N N 67  
ARG   N   H2   sing N N 68  
ARG   CA  C    sing N N 69  
ARG   CA  CB   sing N N 70  
ARG   CA  HA   sing N N 71  
ARG   C   O    doub N N 72  
ARG   C   OXT  sing N N 73  
ARG   CB  CG   sing N N 74  
ARG   CB  HB2  sing N N 75  
ARG   CB  HB3  sing N N 76  
ARG   CG  CD   sing N N 77  
ARG   CG  HG2  sing N N 78  
ARG   CG  HG3  sing N N 79  
ARG   CD  NE   sing N N 80  
ARG   CD  HD2  sing N N 81  
ARG   CD  HD3  sing N N 82  
ARG   NE  CZ   sing N N 83  
ARG   NE  HE   sing N N 84  
ARG   CZ  NH1  sing N N 85  
ARG   CZ  NH2  doub N N 86  
ARG   NH1 HH11 sing N N 87  
ARG   NH1 HH12 sing N N 88  
ARG   NH2 HH21 sing N N 89  
ARG   NH2 HH22 sing N N 90  
ARG   OXT HXT  sing N N 91  
ASN   N   CA   sing N N 92  
ASN   N   H    sing N N 93  
ASN   N   H2   sing N N 94  
ASN   CA  C    sing N N 95  
ASN   CA  CB   sing N N 96  
ASN   CA  HA   sing N N 97  
ASN   C   O    doub N N 98  
ASN   C   OXT  sing N N 99  
ASN   CB  CG   sing N N 100 
ASN   CB  HB2  sing N N 101 
ASN   CB  HB3  sing N N 102 
ASN   CG  OD1  doub N N 103 
ASN   CG  ND2  sing N N 104 
ASN   ND2 HD21 sing N N 105 
ASN   ND2 HD22 sing N N 106 
ASN   OXT HXT  sing N N 107 
ASP   N   CA   sing N N 108 
ASP   N   H    sing N N 109 
ASP   N   H2   sing N N 110 
ASP   CA  C    sing N N 111 
ASP   CA  CB   sing N N 112 
ASP   CA  HA   sing N N 113 
ASP   C   O    doub N N 114 
ASP   C   OXT  sing N N 115 
ASP   CB  CG   sing N N 116 
ASP   CB  HB2  sing N N 117 
ASP   CB  HB3  sing N N 118 
ASP   CG  OD1  doub N N 119 
ASP   CG  OD2  sing N N 120 
ASP   OD2 HD2  sing N N 121 
ASP   OXT HXT  sing N N 122 
CYS   N   CA   sing N N 123 
CYS   N   H    sing N N 124 
CYS   N   H2   sing N N 125 
CYS   CA  C    sing N N 126 
CYS   CA  CB   sing N N 127 
CYS   CA  HA   sing N N 128 
CYS   C   O    doub N N 129 
CYS   C   OXT  sing N N 130 
CYS   CB  SG   sing N N 131 
CYS   CB  HB2  sing N N 132 
CYS   CB  HB3  sing N N 133 
CYS   SG  HG   sing N N 134 
CYS   OXT HXT  sing N N 135 
DMS   S   O    doub N N 136 
DMS   S   C1   sing N N 137 
DMS   S   C2   sing N N 138 
DMS   C1  H11  sing N N 139 
DMS   C1  H12  sing N N 140 
DMS   C1  H13  sing N N 141 
DMS   C2  H21  sing N N 142 
DMS   C2  H22  sing N N 143 
DMS   C2  H23  sing N N 144 
GLN   N   CA   sing N N 145 
GLN   N   H    sing N N 146 
GLN   N   H2   sing N N 147 
GLN   CA  C    sing N N 148 
GLN   CA  CB   sing N N 149 
GLN   CA  HA   sing N N 150 
GLN   C   O    doub N N 151 
GLN   C   OXT  sing N N 152 
GLN   CB  CG   sing N N 153 
GLN   CB  HB2  sing N N 154 
GLN   CB  HB3  sing N N 155 
GLN   CG  CD   sing N N 156 
GLN   CG  HG2  sing N N 157 
GLN   CG  HG3  sing N N 158 
GLN   CD  OE1  doub N N 159 
GLN   CD  NE2  sing N N 160 
GLN   NE2 HE21 sing N N 161 
GLN   NE2 HE22 sing N N 162 
GLN   OXT HXT  sing N N 163 
GLU   N   CA   sing N N 164 
GLU   N   H    sing N N 165 
GLU   N   H2   sing N N 166 
GLU   CA  C    sing N N 167 
GLU   CA  CB   sing N N 168 
GLU   CA  HA   sing N N 169 
GLU   C   O    doub N N 170 
GLU   C   OXT  sing N N 171 
GLU   CB  CG   sing N N 172 
GLU   CB  HB2  sing N N 173 
GLU   CB  HB3  sing N N 174 
GLU   CG  CD   sing N N 175 
GLU   CG  HG2  sing N N 176 
GLU   CG  HG3  sing N N 177 
GLU   CD  OE1  doub N N 178 
GLU   CD  OE2  sing N N 179 
GLU   OE2 HE2  sing N N 180 
GLU   OXT HXT  sing N N 181 
GLY   N   CA   sing N N 182 
GLY   N   H    sing N N 183 
GLY   N   H2   sing N N 184 
GLY   CA  C    sing N N 185 
GLY   CA  HA2  sing N N 186 
GLY   CA  HA3  sing N N 187 
GLY   C   O    doub N N 188 
GLY   C   OXT  sing N N 189 
GLY   OXT HXT  sing N N 190 
HIS   N   CA   sing N N 191 
HIS   N   H    sing N N 192 
HIS   N   H2   sing N N 193 
HIS   CA  C    sing N N 194 
HIS   CA  CB   sing N N 195 
HIS   CA  HA   sing N N 196 
HIS   C   O    doub N N 197 
HIS   C   OXT  sing N N 198 
HIS   CB  CG   sing N N 199 
HIS   CB  HB2  sing N N 200 
HIS   CB  HB3  sing N N 201 
HIS   CG  ND1  sing Y N 202 
HIS   CG  CD2  doub Y N 203 
HIS   ND1 CE1  doub Y N 204 
HIS   ND1 HD1  sing N N 205 
HIS   CD2 NE2  sing Y N 206 
HIS   CD2 HD2  sing N N 207 
HIS   CE1 NE2  sing Y N 208 
HIS   CE1 HE1  sing N N 209 
HIS   NE2 HE2  sing N N 210 
HIS   OXT HXT  sing N N 211 
HOH   O   H1   sing N N 212 
HOH   O   H2   sing N N 213 
ILE   N   CA   sing N N 214 
ILE   N   H    sing N N 215 
ILE   N   H2   sing N N 216 
ILE   CA  C    sing N N 217 
ILE   CA  CB   sing N N 218 
ILE   CA  HA   sing N N 219 
ILE   C   O    doub N N 220 
ILE   C   OXT  sing N N 221 
ILE   CB  CG1  sing N N 222 
ILE   CB  CG2  sing N N 223 
ILE   CB  HB   sing N N 224 
ILE   CG1 CD1  sing N N 225 
ILE   CG1 HG12 sing N N 226 
ILE   CG1 HG13 sing N N 227 
ILE   CG2 HG21 sing N N 228 
ILE   CG2 HG22 sing N N 229 
ILE   CG2 HG23 sing N N 230 
ILE   CD1 HD11 sing N N 231 
ILE   CD1 HD12 sing N N 232 
ILE   CD1 HD13 sing N N 233 
ILE   OXT HXT  sing N N 234 
LEU   N   CA   sing N N 235 
LEU   N   H    sing N N 236 
LEU   N   H2   sing N N 237 
LEU   CA  C    sing N N 238 
LEU   CA  CB   sing N N 239 
LEU   CA  HA   sing N N 240 
LEU   C   O    doub N N 241 
LEU   C   OXT  sing N N 242 
LEU   CB  CG   sing N N 243 
LEU   CB  HB2  sing N N 244 
LEU   CB  HB3  sing N N 245 
LEU   CG  CD1  sing N N 246 
LEU   CG  CD2  sing N N 247 
LEU   CG  HG   sing N N 248 
LEU   CD1 HD11 sing N N 249 
LEU   CD1 HD12 sing N N 250 
LEU   CD1 HD13 sing N N 251 
LEU   CD2 HD21 sing N N 252 
LEU   CD2 HD22 sing N N 253 
LEU   CD2 HD23 sing N N 254 
LEU   OXT HXT  sing N N 255 
LYS   N   CA   sing N N 256 
LYS   N   H    sing N N 257 
LYS   N   H2   sing N N 258 
LYS   CA  C    sing N N 259 
LYS   CA  CB   sing N N 260 
LYS   CA  HA   sing N N 261 
LYS   C   O    doub N N 262 
LYS   C   OXT  sing N N 263 
LYS   CB  CG   sing N N 264 
LYS   CB  HB2  sing N N 265 
LYS   CB  HB3  sing N N 266 
LYS   CG  CD   sing N N 267 
LYS   CG  HG2  sing N N 268 
LYS   CG  HG3  sing N N 269 
LYS   CD  CE   sing N N 270 
LYS   CD  HD2  sing N N 271 
LYS   CD  HD3  sing N N 272 
LYS   CE  NZ   sing N N 273 
LYS   CE  HE2  sing N N 274 
LYS   CE  HE3  sing N N 275 
LYS   NZ  HZ1  sing N N 276 
LYS   NZ  HZ2  sing N N 277 
LYS   NZ  HZ3  sing N N 278 
LYS   OXT HXT  sing N N 279 
MET   N   CA   sing N N 280 
MET   N   H    sing N N 281 
MET   N   H2   sing N N 282 
MET   CA  C    sing N N 283 
MET   CA  CB   sing N N 284 
MET   CA  HA   sing N N 285 
MET   C   O    doub N N 286 
MET   C   OXT  sing N N 287 
MET   CB  CG   sing N N 288 
MET   CB  HB2  sing N N 289 
MET   CB  HB3  sing N N 290 
MET   CG  SD   sing N N 291 
MET   CG  HG2  sing N N 292 
MET   CG  HG3  sing N N 293 
MET   SD  CE   sing N N 294 
MET   CE  HE1  sing N N 295 
MET   CE  HE2  sing N N 296 
MET   CE  HE3  sing N N 297 
MET   OXT HXT  sing N N 298 
MPD   C1  C2   sing N N 299 
MPD   C1  H11  sing N N 300 
MPD   C1  H12  sing N N 301 
MPD   C1  H13  sing N N 302 
MPD   C2  O2   sing N N 303 
MPD   C2  CM   sing N N 304 
MPD   C2  C3   sing N N 305 
MPD   O2  HO2  sing N N 306 
MPD   CM  HM1  sing N N 307 
MPD   CM  HM2  sing N N 308 
MPD   CM  HM3  sing N N 309 
MPD   C3  C4   sing N N 310 
MPD   C3  H31  sing N N 311 
MPD   C3  H32  sing N N 312 
MPD   C4  O4   sing N N 313 
MPD   C4  C5   sing N N 314 
MPD   C4  H4   sing N N 315 
MPD   O4  HO4  sing N N 316 
MPD   C5  H51  sing N N 317 
MPD   C5  H52  sing N N 318 
MPD   C5  H53  sing N N 319 
PHE   N   CA   sing N N 320 
PHE   N   H    sing N N 321 
PHE   N   H2   sing N N 322 
PHE   CA  C    sing N N 323 
PHE   CA  CB   sing N N 324 
PHE   CA  HA   sing N N 325 
PHE   C   O    doub N N 326 
PHE   C   OXT  sing N N 327 
PHE   CB  CG   sing N N 328 
PHE   CB  HB2  sing N N 329 
PHE   CB  HB3  sing N N 330 
PHE   CG  CD1  doub Y N 331 
PHE   CG  CD2  sing Y N 332 
PHE   CD1 CE1  sing Y N 333 
PHE   CD1 HD1  sing N N 334 
PHE   CD2 CE2  doub Y N 335 
PHE   CD2 HD2  sing N N 336 
PHE   CE1 CZ   doub Y N 337 
PHE   CE1 HE1  sing N N 338 
PHE   CE2 CZ   sing Y N 339 
PHE   CE2 HE2  sing N N 340 
PHE   CZ  HZ   sing N N 341 
PHE   OXT HXT  sing N N 342 
PRO   N   CA   sing N N 343 
PRO   N   CD   sing N N 344 
PRO   N   H    sing N N 345 
PRO   CA  C    sing N N 346 
PRO   CA  CB   sing N N 347 
PRO   CA  HA   sing N N 348 
PRO   C   O    doub N N 349 
PRO   C   OXT  sing N N 350 
PRO   CB  CG   sing N N 351 
PRO   CB  HB2  sing N N 352 
PRO   CB  HB3  sing N N 353 
PRO   CG  CD   sing N N 354 
PRO   CG  HG2  sing N N 355 
PRO   CG  HG3  sing N N 356 
PRO   CD  HD2  sing N N 357 
PRO   CD  HD3  sing N N 358 
PRO   OXT HXT  sing N N 359 
SER   N   CA   sing N N 360 
SER   N   H    sing N N 361 
SER   N   H2   sing N N 362 
SER   CA  C    sing N N 363 
SER   CA  CB   sing N N 364 
SER   CA  HA   sing N N 365 
SER   C   O    doub N N 366 
SER   C   OXT  sing N N 367 
SER   CB  OG   sing N N 368 
SER   CB  HB2  sing N N 369 
SER   CB  HB3  sing N N 370 
SER   OG  HG   sing N N 371 
SER   OXT HXT  sing N N 372 
THR   N   CA   sing N N 373 
THR   N   H    sing N N 374 
THR   N   H2   sing N N 375 
THR   CA  C    sing N N 376 
THR   CA  CB   sing N N 377 
THR   CA  HA   sing N N 378 
THR   C   O    doub N N 379 
THR   C   OXT  sing N N 380 
THR   CB  OG1  sing N N 381 
THR   CB  CG2  sing N N 382 
THR   CB  HB   sing N N 383 
THR   OG1 HG1  sing N N 384 
THR   CG2 HG21 sing N N 385 
THR   CG2 HG22 sing N N 386 
THR   CG2 HG23 sing N N 387 
THR   OXT HXT  sing N N 388 
TRP   N   CA   sing N N 389 
TRP   N   H    sing N N 390 
TRP   N   H2   sing N N 391 
TRP   CA  C    sing N N 392 
TRP   CA  CB   sing N N 393 
TRP   CA  HA   sing N N 394 
TRP   C   O    doub N N 395 
TRP   C   OXT  sing N N 396 
TRP   CB  CG   sing N N 397 
TRP   CB  HB2  sing N N 398 
TRP   CB  HB3  sing N N 399 
TRP   CG  CD1  doub Y N 400 
TRP   CG  CD2  sing Y N 401 
TRP   CD1 NE1  sing Y N 402 
TRP   CD1 HD1  sing N N 403 
TRP   CD2 CE2  doub Y N 404 
TRP   CD2 CE3  sing Y N 405 
TRP   NE1 CE2  sing Y N 406 
TRP   NE1 HE1  sing N N 407 
TRP   CE2 CZ2  sing Y N 408 
TRP   CE3 CZ3  doub Y N 409 
TRP   CE3 HE3  sing N N 410 
TRP   CZ2 CH2  doub Y N 411 
TRP   CZ2 HZ2  sing N N 412 
TRP   CZ3 CH2  sing Y N 413 
TRP   CZ3 HZ3  sing N N 414 
TRP   CH2 HH2  sing N N 415 
TRP   OXT HXT  sing N N 416 
TYR   N   CA   sing N N 417 
TYR   N   H    sing N N 418 
TYR   N   H2   sing N N 419 
TYR   CA  C    sing N N 420 
TYR   CA  CB   sing N N 421 
TYR   CA  HA   sing N N 422 
TYR   C   O    doub N N 423 
TYR   C   OXT  sing N N 424 
TYR   CB  CG   sing N N 425 
TYR   CB  HB2  sing N N 426 
TYR   CB  HB3  sing N N 427 
TYR   CG  CD1  doub Y N 428 
TYR   CG  CD2  sing Y N 429 
TYR   CD1 CE1  sing Y N 430 
TYR   CD1 HD1  sing N N 431 
TYR   CD2 CE2  doub Y N 432 
TYR   CD2 HD2  sing N N 433 
TYR   CE1 CZ   doub Y N 434 
TYR   CE1 HE1  sing N N 435 
TYR   CE2 CZ   sing Y N 436 
TYR   CE2 HE2  sing N N 437 
TYR   CZ  OH   sing N N 438 
TYR   OH  HH   sing N N 439 
TYR   OXT HXT  sing N N 440 
VAL   N   CA   sing N N 441 
VAL   N   H    sing N N 442 
VAL   N   H2   sing N N 443 
VAL   CA  C    sing N N 444 
VAL   CA  CB   sing N N 445 
VAL   CA  HA   sing N N 446 
VAL   C   O    doub N N 447 
VAL   C   OXT  sing N N 448 
VAL   CB  CG1  sing N N 449 
VAL   CB  CG2  sing N N 450 
VAL   CB  HB   sing N N 451 
VAL   CG1 HG11 sing N N 452 
VAL   CG1 HG12 sing N N 453 
VAL   CG1 HG13 sing N N 454 
VAL   CG2 HG21 sing N N 455 
VAL   CG2 HG22 sing N N 456 
VAL   CG2 HG23 sing N N 457 
VAL   OXT HXT  sing N N 458 
# 
_pdbx_audit_support.funding_organization   'Jane and Aatos Erkko Foundation' 
_pdbx_audit_support.country                Finland 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7Z2O 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FEG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022093 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014607 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006266 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASN   A 1 3   ? -3.01130  14.32641  28.41046  1.000 55.65350 ? 481 ASN   B N    1 
ATOM   2    C CA   . ASN   A 1 3   ? -2.82375  15.76395  28.61389  1.000 55.27213 ? 481 ASN   B CA   1 
ATOM   3    C C    . ASN   A 1 3   ? -1.49886  16.03191  29.32362  1.000 42.96837 ? 481 ASN   B C    1 
ATOM   4    O O    . ASN   A 1 3   ? -1.17721  15.36506  30.34600  1.000 40.45198 ? 481 ASN   B O    1 
ATOM   5    C CB   . ASN   A 1 3   ? -3.98654  16.34483  29.42773  1.000 60.45199 ? 481 ASN   B CB   1 
ATOM   6    H HA   . ASN   A 1 3   ? -2.80773  16.21370  27.75460  1.000 66.28057 ? 481 ASN   B HA   1 
ATOM   7    N N    . LEU   A 1 4   ? -0.72153  16.98980  28.80138  1.000 36.71710 ? 482 LEU   B N    1 
ATOM   8    C CA   . LEU   A 1 4   ? 0.58555   17.26311  29.39956  1.000 29.51187 ? 482 LEU   B CA   1 
ATOM   9    C C    . LEU   A 1 4   ? 0.40664   18.02895  30.70491  1.000 26.89379 ? 482 LEU   B C    1 
ATOM   10   O O    . LEU   A 1 4   ? -0.46107  18.90926  30.79776  1.000 28.80653 ? 482 LEU   B O    1 
ATOM   11   C CB   . LEU   A 1 4   ? 1.47869   18.05965  28.45303  1.000 24.28154 ? 482 LEU   B CB   1 
ATOM   12   C CG   . LEU   A 1 4   ? 1.82122   17.41486  27.09509  1.000 24.99447 ? 482 LEU   B CG   1 
ATOM   13   C CD1  . LEU   A 1 4   ? 2.85228   18.21465  26.32801  1.000 26.55687 ? 482 LEU   B CD1  1 
ATOM   14   C CD2  . LEU   A 1 4   ? 2.29086   15.97776  27.28467  1.000 25.15065 ? 482 LEU   B CD2  1 
ATOM   15   H H    . LEU   A 1 4   ? -0.92314  17.47852  28.12307  1.000 44.01453 ? 482 LEU   B H    1 
ATOM   16   H HA   . LEU   A 1 4   ? 1.03048   16.42094  29.58311  1.000 35.36826 ? 482 LEU   B HA   1 
ATOM   17   H HB2  . LEU   A 1 4   ? 1.03420   18.90029  28.26161  1.000 29.09186 ? 482 LEU   B HB2  1 
ATOM   18   H HB3  . LEU   A 1 4   ? 2.32002   18.22498  28.90661  1.000 29.09186 ? 482 LEU   B HB3  1 
ATOM   19   H HG   . LEU   A 1 4   ? 1.01289   17.40672  26.55895  1.000 29.94738 ? 482 LEU   B HG   1 
ATOM   20   H HD11 . LEU   A 1 4   ? 3.02902   17.77348  25.48241  1.000 31.82226 ? 482 LEU   B HD11 1 
ATOM   21   H HD12 . LEU   A 1 4   ? 2.50603   19.10680  26.16962  1.000 31.82226 ? 482 LEU   B HD12 1 
ATOM   22   H HD13 . LEU   A 1 4   ? 3.66715   18.26427  26.85188  1.000 31.82226 ? 482 LEU   B HD13 1 
ATOM   23   H HD21 . LEU   A 1 4   ? 2.65122   15.65003  26.44584  1.000 30.13480 ? 482 LEU   B HD21 1 
ATOM   24   H HD22 . LEU   A 1 4   ? 2.97713   15.95758  27.96988  1.000 30.13480 ? 482 LEU   B HD22 1 
ATOM   25   H HD23 . LEU   A 1 4   ? 1.53622   15.43212  27.55616  1.000 30.13480 ? 482 LEU   B HD23 1 
ATOM   26   N N    . PRO   A 1 5   ? 1.18462   17.70718  31.73661  1.000 22.81123 ? 483 PRO   B N    1 
ATOM   27   C CA   . PRO   A 1 5   ? 1.02123   18.40192  33.02462  1.000 25.42717 ? 483 PRO   B CA   1 
ATOM   28   C C    . PRO   A 1 5   ? 1.19574   19.91474  32.91459  1.000 23.75562 ? 483 PRO   B C    1 
ATOM   29   O O    . PRO   A 1 5   ? 2.09735   20.41931  32.23495  1.000 22.75462 ? 483 PRO   B O    1 
ATOM   30   C CB   . PRO   A 1 5   ? 2.11246   17.77168  33.90225  1.000 24.85725 ? 483 PRO   B CB   1 
ATOM   31   C CG   . PRO   A 1 5   ? 2.45737   16.49201  33.23629  1.000 23.89857 ? 483 PRO   B CG   1 
ATOM   32   C CD   . PRO   A 1 5   ? 2.28204   16.72062  31.76761  1.000 23.45759 ? 483 PRO   B CD   1 
ATOM   33   H HA   . PRO   A 1 5   ? 0.14107   18.21687  33.38791  1.000 30.46662 ? 483 PRO   B HA   1 
ATOM   34   H HB2  . PRO   A 1 5   ? 2.88286   18.35969  33.94263  1.000 29.78271 ? 483 PRO   B HB2  1 
ATOM   35   H HB3  . PRO   A 1 5   ? 1.76729   17.61533  34.79517  1.000 29.78271 ? 483 PRO   B HB3  1 
ATOM   36   H HG2  . PRO   A 1 5   ? 3.37676   16.25787  33.43829  1.000 28.63230 ? 483 PRO   B HG2  1 
ATOM   37   H HG3  . PRO   A 1 5   ? 1.86105   15.79283  33.54685  1.000 28.63230 ? 483 PRO   B HG3  1 
ATOM   38   H HD2  . PRO   A 1 5   ? 3.08966   17.08332  31.37127  1.000 28.10312 ? 483 PRO   B HD2  1 
ATOM   39   H HD3  . PRO   A 1 5   ? 2.02882   15.90148  31.31396  1.000 28.10312 ? 483 PRO   B HD3  1 
ATOM   40   N N    . GLU   A 1 6   ? 0.33955   20.64420  33.63231  1.000 24.68798 ? 484 GLU   B N    1 
ATOM   41   C CA   . GLU   A 1 6   ? 0.31694   22.09250  33.50216  1.000 27.03817 ? 484 GLU   B CA   1 
ATOM   42   C C    . GLU   A 1 6   ? 1.53115   22.77672  34.11195  1.000 27.51645 ? 484 GLU   B C    1 
ATOM   43   O O    . GLU   A 1 6   ? 1.78185   23.94606  33.79913  1.000 30.68522 ? 484 GLU   B O    1 
ATOM   44   C CB   . GLU   A 1 6   ? -0.93667  22.68408  34.15372  1.000 29.82989 ? 484 GLU   B CB   1 
ATOM   45   C CG   . GLU   A 1 6   ? -2.10131  22.85457  33.20601  1.000 32.55803 ? 484 GLU   B CG   1 
ATOM   46   C CD   . GLU   A 1 6   ? -2.87241  21.58423  33.01998  1.000 34.01046 ? 484 GLU   B CD   1 
ATOM   47   O OE1  . GLU   A 1 6   ? -2.78504  20.73128  33.92571  1.000 36.20532 ? 484 GLU   B OE1  1 
ATOM   48   O OE2  . GLU   A 1 6   ? -3.55900  21.45235  31.96683  1.000 45.54331 ? 484 GLU   B OE2  1 
ATOM   49   H H    . GLU   A 1 6   ? -0.22925  20.32522  34.19295  1.000 29.57959 ? 484 GLU   B H    1 
ATOM   50   H HA   . GLU   A 1 6   ? 0.29924   22.28248  32.55111  1.000 32.39982 ? 484 GLU   B HA   1 
ATOM   51   H HB2  . GLU   A 1 6   ? -1.22250  22.09470  34.86915  1.000 35.74989 ? 484 GLU   B HB2  1 
ATOM   52   H HB3  . GLU   A 1 6   ? -0.71745  23.55849  34.51183  1.000 35.74989 ? 484 GLU   B HB3  1 
ATOM   53   H HG2  . GLU   A 1 6   ? -2.70524  23.52508  33.56181  1.000 39.02365 ? 484 GLU   B HG2  1 
ATOM   54   H HG3  . GLU   A 1 6   ? -1.76767  23.13498  32.33944  1.000 39.02365 ? 484 GLU   B HG3  1 
ATOM   55   N N    . HIS   A 1 7   ? 2.26887   22.09706  34.97851  1.000 26.78919 ? 485 HIS   B N    1 
ATOM   56   C CA   . HIS   A 1 7   ? 3.46960   22.69853  35.54677  1.000 28.27026 ? 485 HIS   B CA   1 
ATOM   57   C C    . HIS   A 1 7   ? 4.68769   22.54187  34.64576  1.000 27.40897 ? 485 HIS   B C    1 
ATOM   58   O O    . HIS   A 1 7   ? 5.74292   23.08399  34.96395  1.000 27.93973 ? 485 HIS   B O    1 
ATOM   59   C CB   . HIS   A 1 7   ? 3.75934   22.09676  36.92556  1.000 26.57844 ? 485 HIS   B CB   1 
ATOM   60   C CG   . HIS   A 1 7   ? 4.08134   20.64355  36.89763  1.000 28.66402 ? 485 HIS   B CG   1 
ATOM   61   N ND1  . HIS   A 1 7   ? 3.14128   19.68316  36.60469  1.000 27.48935 ? 485 HIS   B ND1  1 
ATOM   62   C CD2  . HIS   A 1 7   ? 5.24231   19.98292  37.10962  1.000 28.57753 ? 485 HIS   B CD2  1 
ATOM   63   C CE1  . HIS   A 1 7   ? 3.71867   18.49542  36.63432  1.000 26.48644 ? 485 HIS   B CE1  1 
ATOM   64   N NE2  . HIS   A 1 7   ? 4.99075   18.65308  36.93226  1.000 31.42634 ? 485 HIS   B NE2  1 
ATOM   65   H H    . HIS   A 1 7   ? 2.09954   21.29886  35.25019  1.000 32.10104 ? 485 HIS   B H    1 
ATOM   66   H HA   . HIS   A 1 7   ? 3.31511   23.64808  35.67079  1.000 33.87833 ? 485 HIS   B HA   1 
ATOM   67   H HB2  . HIS   A 1 7   ? 4.51852   22.55955  37.31332  1.000 31.84814 ? 485 HIS   B HB2  1 
ATOM   68   H HB3  . HIS   A 1 7   ? 2.97697   22.21464  37.48672  1.000 31.84814 ? 485 HIS   B HB3  1 
ATOM   69   H HD2  . HIS   A 1 7   ? 6.06029   20.36401  37.33451  1.000 34.24706 ? 485 HIS   B HD2  1 
ATOM   70   H HE1  . HIS   A 1 7   ? 3.29641   17.68293  36.47167  1.000 31.73775 ? 485 HIS   B HE1  1 
ATOM   71   H HE2  . HIS   A 1 7   ? 5.56950   18.02098  37.00363  1.000 37.66562 ? 485 HIS   B HE2  1 
ATOM   72   N N    . TRP   A 1 8   ? 4.58642   21.78687  33.55308  1.000 23.67404 ? 486 TRP   B N    1 
ATOM   73   C CA   . TRP   A 1 8   ? 5.71772   21.66614  32.64875  1.000 21.12683 ? 486 TRP   B CA   1 
ATOM   74   C C    . TRP   A 1 8   ? 5.95711   23.01208  31.95966  1.000 21.71900 ? 486 TRP   B C    1 
ATOM   75   O O    . TRP   A 1 8   ? 5.02714   23.81480  31.77219  1.000 20.73812 ? 486 TRP   B O    1 
ATOM   76   C CB   . TRP   A 1 8   ? 5.46540   20.60576  31.57243  1.000 21.07466 ? 486 TRP   B CB   1 
ATOM   77   C CG   . TRP   A 1 8   ? 5.59569   19.18951  32.05444  1.000 22.14730 ? 486 TRP   B CG   1 
ATOM   78   C CD1  . TRP   A 1 8   ? 5.68136   18.76553  33.35377  1.000 24.03973 ? 486 TRP   B CD1  1 
ATOM   79   C CD2  . TRP   A 1 8   ? 5.66294   18.01969  31.23657  1.000 20.78820 ? 486 TRP   B CD2  1 
ATOM   80   N NE1  . TRP   A 1 8   ? 5.77735   17.38808  33.39233  1.000 22.41269 ? 486 TRP   B NE1  1 
ATOM   81   C CE2  . TRP   A 1 8   ? 5.78576   16.90899  32.10745  1.000 23.78733 ? 486 TRP   B CE2  1 
ATOM   82   C CE3  . TRP   A 1 8   ? 5.60663   17.80005  29.85550  1.000 19.29530 ? 486 TRP   B CE3  1 
ATOM   83   C CZ2  . TRP   A 1 8   ? 5.84403   15.59398  31.63963  1.000 21.27205 ? 486 TRP   B CZ2  1 
ATOM   84   C CZ3  . TRP   A 1 8   ? 5.70208   16.48413  29.38462  1.000 22.24345 ? 486 TRP   B CZ3  1 
ATOM   85   C CH2  . TRP   A 1 8   ? 5.82892   15.40778  30.28819  1.000 20.46107 ? 486 TRP   B CH2  1 
ATOM   86   H H    . TRP   A 1 8   ? 3.88633   21.34476  33.32067  1.000 28.36287 ? 486 TRP   B H    1 
ATOM   87   H HA   . TRP   A 1 8   ? 6.50147   21.39760  33.15326  1.000 25.30622 ? 486 TRP   B HA   1 
ATOM   88   H HB2  . TRP   A 1 8   ? 4.56383   20.71813  31.23264  1.000 25.24361 ? 486 TRP   B HB2  1 
ATOM   89   H HB3  . TRP   A 1 8   ? 6.10783   20.73225  30.85676  1.000 25.24361 ? 486 TRP   B HB3  1 
ATOM   90   H HD1  . TRP   A 1 8   ? 5.67575   19.32193  34.09895  1.000 28.80169 ? 486 TRP   B HD1  1 
ATOM   91   H HE1  . TRP   A 1 8   ? 5.82417   16.90940  34.10527  1.000 26.84924 ? 486 TRP   B HE1  1 
ATOM   92   H HE3  . TRP   A 1 8   ? 5.50814   18.51109  29.26420  1.000 23.10838 ? 486 TRP   B HE3  1 
ATOM   93   H HZ2  . TRP   A 1 8   ? 5.89126   14.87389  32.22627  1.000 25.48048 ? 486 TRP   B HZ2  1 
ATOM   94   H HZ3  . TRP   A 1 8   ? 5.68170   16.31871  28.46968  1.000 26.64616 ? 486 TRP   B HZ3  1 
ATOM   95   H HH2  . TRP   A 1 8   ? 5.90461   14.54406  29.95181  1.000 24.50730 ? 486 TRP   B HH2  1 
ATOM   96   N N    . THR   A 1 9   ? 7.20618   23.24508  31.56515  1.000 22.06141 ? 487 THR   B N    1 
ATOM   97   C CA   . THR   A 1 9   ? 7.50693   24.41897  30.75358  1.000 21.53710 ? 487 THR   B CA   1 
ATOM   98   C C    . THR   A 1 9   ? 6.84020   24.28796  29.39018  1.000 25.20122 ? 487 THR   B C    1 
ATOM   99   O O    . THR   A 1 9   ? 6.67682   23.19042  28.85817  1.000 23.76791 ? 487 THR   B O    1 
ATOM   100  C CB   . THR   A 1 9   ? 9.02048   24.59185  30.57221  1.000 23.22414 ? 487 THR   B CB   1 
ATOM   101  O OG1  . THR   A 1 9   ? 9.50722   23.47464  29.81630  1.000 27.08567 ? 487 THR   B OG1  1 
ATOM   102  C CG2  . THR   A 1 9   ? 9.68861   24.67403  31.89454  1.000 22.56114 ? 487 THR   B CG2  1 
ATOM   103  H H    . THR   A 1 9   ? 7.88357   22.74868  31.75044  1.000 26.42770 ? 487 THR   B H    1 
ATOM   104  H HA   . THR   A 1 9   ? 7.17232   25.21298  31.19909  1.000 25.79854 ? 487 THR   B HA   1 
ATOM   105  H HB   . THR   A 1 9   ? 9.22816   25.41287  30.09925  1.000 27.82298 ? 487 THR   B HB   1 
ATOM   106  H HG1  . THR   A 1 9   ? 10.33521  23.54834  29.69550  1.000 32.45682 ? 487 THR   B HG1  1 
ATOM   107  H HG21 . THR   A 1 9   ? 10.62977  24.87818  31.77859  1.000 27.02738 ? 487 THR   B HG21 1 
ATOM   108  H HG22 . THR   A 1 9   ? 9.27899   25.37110  32.43046  1.000 27.02738 ? 487 THR   B HG22 1 
ATOM   109  H HG23 . THR   A 1 9   ? 9.60522   23.82794  32.36153  1.000 27.02738 ? 487 THR   B HG23 1 
ATOM   110  N N    . ASP   A 1 10  ? 6.46554   25.42581  28.81429  1.000 26.51316 ? 488 ASP   B N    1 
ATOM   111  C CA   . ASP   A 1 10  ? 6.00574   25.45103  27.43566  1.000 34.36699 ? 488 ASP   B CA   1 
ATOM   112  C C    . ASP   A 1 10  ? 7.14343   24.98553  26.53732  1.000 33.59557 ? 488 ASP   B C    1 
ATOM   113  O O    . ASP   A 1 10  ? 8.28823   25.41126  26.68340  1.000 32.82523 ? 488 ASP   B O    1 
ATOM   114  C CB   . ASP   A 1 10  ? 5.55102   26.86168  27.04602  1.000 41.03967 ? 488 ASP   B CB   1 
ATOM   115  C CG   . ASP   A 1 10  ? 4.75744   26.88014  25.74204  1.000 52.96906 ? 488 ASP   B CG   1 
ATOM   116  O OD1  . ASP   A 1 10  ? 4.65696   25.83012  25.06621  1.000 52.92747 ? 488 ASP   B OD1  1 
ATOM   117  O OD2  . ASP   A 1 10  ? 4.22726   27.95189  25.38774  1.000 63.31584 ? 488 ASP   B OD2  1 
ATOM   118  H H    . ASP   A 1 10  ? 6.46890   26.19403  29.20083  1.000 31.76981 ? 488 ASP   B H    1 
ATOM   119  H HA   . ASP   A 1 10  ? 5.24179   24.86412  27.32247  1.000 41.19440 ? 488 ASP   B HA   1 
ATOM   120  H HB2  . ASP   A 1 10  ? 4.98443   27.21753  27.74833  1.000 49.20162 ? 488 ASP   B HB2  1 
ATOM   121  H HB3  . ASP   A 1 10  ? 6.33151   27.42613  26.93147  1.000 49.20162 ? 488 ASP   B HB3  1 
ATOM   122  N N    . MET   A 1 11  ? 6.83521   24.08609  25.62332  1.000 35.31477 ? 489 MET   B N    1 
ATOM   123  C CA   . MET   A 1 11  ? 7.85745   23.50955  24.75949  1.000 43.37722 ? 489 MET   B CA   1 
ATOM   124  C C    . MET   A 1 11  ? 7.77654   24.00760  23.32440  1.000 52.84578 ? 489 MET   B C    1 
ATOM   125  O O    . MET   A 1 11  ? 8.45972   23.46305  22.45155  1.000 56.25677 ? 489 MET   B O    1 
ATOM   126  C CB   . MET   A 1 11  ? 7.76045   21.98864  24.80395  1.000 37.66594 ? 489 MET   B CB   1 
ATOM   127  C CG   . MET   A 1 11  ? 8.24009   21.43412  26.12397  1.000 37.66515 ? 489 MET   B CG   1 
ATOM   128  S SD   . MET   A 1 11  ? 8.42792   19.65223  26.10676  1.000 32.00935 ? 489 MET   B SD   1 
ATOM   129  C CE   . MET   A 1 11  ? 6.75160   19.20285  26.14641  1.000 21.93997 ? 489 MET   B CE   1 
ATOM   130  H H    . MET   A 1 11  ? 6.04040   23.79023  25.48067  1.000 42.33174 ? 489 MET   B H    1 
ATOM   131  H HA   . MET   A 1 11  ? 8.72784   23.76468  25.10333  1.000 52.00668 ? 489 MET   B HA   1 
ATOM   132  H HB2  . MET   A 1 11  ? 6.83542   21.72398  24.68073  1.000 45.15315 ? 489 MET   B HB2  1 
ATOM   133  H HB3  . MET   A 1 11  ? 8.30984   21.61291  24.09833  1.000 45.15315 ? 489 MET   B HB3  1 
ATOM   134  H HG2  . MET   A 1 11  ? 9.10298   21.82382  26.33478  1.000 45.15219 ? 489 MET   B HG2  1 
ATOM   135  H HG3  . MET   A 1 11  ? 7.59649   21.66039  26.81353  1.000 45.15219 ? 489 MET   B HG3  1 
ATOM   136  H HE1  . MET   A 1 11  ? 6.68404   18.23521  26.14964  1.000 26.28198 ? 489 MET   B HE1  1 
ATOM   137  H HE2  . MET   A 1 11  ? 6.34637   19.56541  26.94968  1.000 26.28198 ? 489 MET   B HE2  1 
ATOM   138  H HE3  . MET   A 1 11  ? 6.30954   19.56268  25.36156  1.000 26.28198 ? 489 MET   B HE3  1 
ATOM   139  N N    . ASN   A 1 12  ? 6.97558   25.03980  23.06472  1.000 59.34400 ? 490 ASN   B N    1 
ATOM   140  C CA   . ASN   A 1 12  ? 6.95222   25.69961  21.76064  1.000 66.68244 ? 490 ASN   B CA   1 
ATOM   141  C C    . ASN   A 1 12  ? 6.67835   24.68710  20.65128  1.000 67.65366 ? 490 ASN   B C    1 
ATOM   142  O O    . ASN   A 1 12  ? 7.34496   24.66486  19.61221  1.000 69.48887 ? 490 ASN   B O    1 
ATOM   143  C CB   . ASN   A 1 12  ? 8.26626   26.44970  21.51522  1.000 69.44857 ? 490 ASN   B CB   1 
ATOM   144  C CG   . ASN   A 1 12  ? 8.06017   27.77351  20.80700  1.000 78.25285 ? 490 ASN   B CG   1 
ATOM   145  O OD1  . ASN   A 1 12  ? 6.99871   28.39068  20.91283  1.000 81.17220 ? 490 ASN   B OD1  1 
ATOM   146  N ND2  . ASN   A 1 12  ? 9.08068   28.21922  20.08120  1.000 76.56966 ? 490 ASN   B ND2  1 
ATOM   147  H H    . ASN   A 1 12  ? 6.42949   25.38053  23.63506  1.000 71.16681 ? 490 ASN   B H    1 
ATOM   148  H HA   . ASN   A 1 12  ? 6.23094   26.34804  21.74654  1.000 79.97295 ? 490 ASN   B HA   1 
ATOM   149  H HB2  . ASN   A 1 12  ? 8.69246   26.62859  22.36801  1.000 83.29230 ? 490 ASN   B HB2  1 
ATOM   150  H HB3  . ASN   A 1 12  ? 8.84545   25.90102  20.96350  1.000 83.29230 ? 490 ASN   B HB3  1 
ATOM   151  H HD21 . ASN   A 1 12  ? 9.01471   28.96574  19.65936  1.000 91.83761 ? 490 ASN   B HD21 1 
ATOM   152  H HD22 . ASN   A 1 12  ? 9.80692   27.76106  20.03346  1.000 91.83761 ? 490 ASN   B HD22 1 
ATOM   153  N N    . HIS   A 1 13  ? 5.67775   23.83683  20.88383  1.000 61.78069 ? 491 HIS   B N    1 
ATOM   154  C CA   . HIS   A 1 13  ? 5.24585   22.78943  19.96625  1.000 63.14289 ? 491 HIS   B CA   1 
ATOM   155  C C    . HIS   A 1 13  ? 6.26544   21.65462  19.84158  1.000 66.15470 ? 491 HIS   B C    1 
ATOM   156  O O    . HIS   A 1 13  ? 5.99925   20.67818  19.12018  1.000 67.70158 ? 491 HIS   B O    1 
ATOM   157  C CB   . HIS   A 1 13  ? 4.94970   23.33739  18.56012  1.000 68.90124 ? 491 HIS   B CB   1 
ATOM   158  C CG   . HIS   A 1 13  ? 4.24752   24.66079  18.56461  1.000 82.10720 ? 491 HIS   B CG   1 
ATOM   159  N ND1  . HIS   A 1 13  ? 4.92480   25.86305  18.53941  1.000 78.95599 ? 491 HIS   B ND1  1 
ATOM   160  C CD2  . HIS   A 1 13  ? 2.92947   24.97143  18.60846  1.000 77.88345 ? 491 HIS   B CD2  1 
ATOM   161  C CE1  . HIS   A 1 13  ? 4.05421   26.85587  18.56089  1.000 72.20511 ? 491 HIS   B CE1  1 
ATOM   162  N NE2  . HIS   A 1 13  ? 2.83727   26.34213  18.60097  1.000 74.88912 ? 491 HIS   B NE2  1 
ATOM   163  H H    . HIS   A 1 13  ? 5.21265   23.85273  21.60704  1.000 74.09084 ? 491 HIS   B H    1 
ATOM   164  H HA   . HIS   A 1 13  ? 4.42702   22.40885  20.32061  1.000 75.72548 ? 491 HIS   B HA   1 
ATOM   165  H HB2  . HIS   A 1 13  ? 5.78835   23.44865  18.08557  1.000 82.63550 ? 491 HIS   B HB2  1 
ATOM   166  H HB3  . HIS   A 1 13  ? 4.38457   22.70380  18.09097  1.000 82.63550 ? 491 HIS   B HB3  1 
ATOM   167  H HD1  . HIS   A 1 13  ? 5.77982   25.95179  18.51373  1.000 94.70120 ? 491 HIS   B HD1  1 
ATOM   168  H HD2  . HIS   A 1 13  ? 2.22069   24.37005  18.63806  1.000 93.41416 ? 491 HIS   B HD2  1 
ATOM   169  H HE1  . HIS   A 1 13  ? 4.26214   27.76226  18.54973  1.000 86.60015 ? 491 HIS   B HE1  1 
ATOM   170  N N    . GLN   A 1 14  ? 7.41659   21.74203  20.50957  1.000 56.53177 ? 492 GLN   B N    1 
ATOM   171  C CA   . GLN   A 1 14  ? 8.37589   20.64820  20.49257  1.000 53.36981 ? 492 GLN   B CA   1 
ATOM   172  C C    . GLN   A 1 14  ? 7.85759   19.47414  21.32101  1.000 44.37918 ? 492 GLN   B C    1 
ATOM   173  O O    . GLN   A 1 14  ? 6.94490   19.60908  22.13641  1.000 42.70088 ? 492 GLN   B O    1 
ATOM   174  C CB   . GLN   A 1 14  ? 9.72886   21.10463  21.03017  1.000 48.99130 ? 492 GLN   B CB   1 
ATOM   175  C CG   . GLN   A 1 14  ? 10.33685  22.26612  20.26263  1.000 57.79628 ? 492 GLN   B CG   1 
ATOM   176  C CD   . GLN   A 1 14  ? 10.70106  21.89805  18.83822  1.000 67.26430 ? 492 GLN   B CD   1 
ATOM   177  O OE1  . GLN   A 1 14  ? 9.96142   22.20218  17.89858  1.000 71.35245 ? 492 GLN   B OE1  1 
ATOM   178  N NE2  . GLN   A 1 14  ? 11.84874  21.24115  18.66859  1.000 64.05709 ? 492 GLN   B NE2  1 
ATOM   179  H H    . GLN   A 1 14  ? 7.66107   22.42162  20.97647  1.000 67.79214 ? 492 GLN   B H    1 
ATOM   180  H HA   . GLN   A 1 14  ? 8.50372   20.34908  19.57874  1.000 63.99779 ? 492 GLN   B HA   1 
ATOM   181  H HB2  . GLN   A 1 14  ? 9.61872   21.38518  21.95216  1.000 58.74357 ? 492 GLN   B HB2  1 
ATOM   182  H HB3  . GLN   A 1 14  ? 10.34987  20.36107  20.98157  1.000 58.74357 ? 492 GLN   B HB3  1 
ATOM   183  H HG2  . GLN   A 1 14  ? 9.69643   22.99394  20.23037  1.000 69.30955 ? 492 GLN   B HG2  1 
ATOM   184  H HG3  . GLN   A 1 14  ? 11.14520  22.55526  20.71415  1.000 69.30955 ? 492 GLN   B HG3  1 
ATOM   185  H HE21 . GLN   A 1 14  ? 12.33850  21.04846  19.34874  1.000 76.82253 ? 492 GLN   B HE21 1 
ATOM   186  H HE22 . GLN   A 1 14  ? 12.09931  21.01010  17.87901  1.000 76.82253 ? 492 GLN   B HE22 1 
ATOM   187  N N    . LEU   A 1 15  ? 8.46806   18.31135  21.10915  1.000 37.07154 ? 493 LEU   B N    1 
ATOM   188  C CA   . LEU   A 1 15  ? 7.99561   17.07291  21.71666  1.000 35.09482 ? 493 LEU   B CA   1 
ATOM   189  C C    . LEU   A 1 15  ? 8.84488   16.62235  22.89749  1.000 28.77142 ? 493 LEU   B C    1 
ATOM   190  O O    . LEU   A 1 15  ? 8.45255   15.68551  23.60178  1.000 23.12005 ? 493 LEU   B O    1 
ATOM   191  C CB   . LEU   A 1 15  ? 7.96687   15.95246  20.66749  1.000 35.58244 ? 493 LEU   B CB   1 
ATOM   192  C CG   . LEU   A 1 15  ? 7.07428   16.17740  19.44116  1.000 35.67701 ? 493 LEU   B CG   1 
ATOM   193  C CD1  . LEU   A 1 15  ? 7.23792   15.06992  18.42542  1.000 35.98212 ? 493 LEU   B CD1  1 
ATOM   194  C CD2  . LEU   A 1 15  ? 5.61885   16.31550  19.84479  1.000 35.67338 ? 493 LEU   B CD2  1 
ATOM   195  H H    . LEU   A 1 15  ? 9.16376   18.21411  20.61301  1.000 44.43986 ? 493 LEU   B H    1 
ATOM   196  H HA   . LEU   A 1 15  ? 7.09091   17.21210  22.03767  1.000 42.06780 ? 493 LEU   B HA   1 
ATOM   197  H HB2  . LEU   A 1 15  ? 8.87125   15.82498  20.34079  1.000 42.65295 ? 493 LEU   B HB2  1 
ATOM   198  H HB3  . LEU   A 1 15  ? 7.65392   15.14357  21.10184  1.000 42.65295 ? 493 LEU   B HB3  1 
ATOM   199  H HG   . LEU   A 1 15  ? 7.35057   17.00602  19.01930  1.000 42.76643 ? 493 LEU   B HG   1 
ATOM   200  H HD11 . LEU   A 1 15  ? 6.65169   15.24303  17.67225  1.000 43.13255 ? 493 LEU   B HD11 1 
ATOM   201  H HD12 . LEU   A 1 15  ? 8.16093   15.04806  18.12797  1.000 43.13255 ? 493 LEU   B HD12 1 
ATOM   202  H HD13 . LEU   A 1 15  ? 7.00370   14.22455  18.83943  1.000 43.13255 ? 493 LEU   B HD13 1 
ATOM   203  H HD21 . LEU   A 1 15  ? 5.07253   16.36434  19.04475  1.000 42.76207 ? 493 LEU   B HD21 1 
ATOM   204  H HD22 . LEU   A 1 15  ? 5.36309   15.54343  20.37336  1.000 42.76207 ? 493 LEU   B HD22 1 
ATOM   205  H HD23 . LEU   A 1 15  ? 5.51178   17.12500  20.36837  1.000 42.76207 ? 493 LEU   B HD23 1 
ATOM   206  N N    . PHE   A 1 16  ? 9.99233   17.24922  23.13065  1.000 29.99227 ? 494 PHE   B N    1 
ATOM   207  C CA   . PHE   A 1 16  ? 10.89460  16.77725  24.17311  1.000 26.33231 ? 494 PHE   B CA   1 
ATOM   208  C C    . PHE   A 1 16  ? 11.79473  17.91392  24.62868  1.000 27.02414 ? 494 PHE   B C    1 
ATOM   209  O O    . PHE   A 1 16  ? 12.21992  18.72943  23.81021  1.000 26.77965 ? 494 PHE   B O    1 
ATOM   210  C CB   . PHE   A 1 16  ? 11.75031  15.61760  23.67772  1.000 28.88056 ? 494 PHE   B CB   1 
ATOM   211  C CG   . PHE   A 1 16  ? 12.97735  15.36547  24.51738  1.000 25.05208 ? 494 PHE   B CG   1 
ATOM   212  C CD1  . PHE   A 1 16  ? 12.91589  14.54892  25.61303  1.000 23.71606 ? 494 PHE   B CD1  1 
ATOM   213  C CD2  . PHE   A 1 16  ? 14.18061  15.98055  24.20874  1.000 30.05072 ? 494 PHE   B CD2  1 
ATOM   214  C CE1  . PHE   A 1 16  ? 14.01227  14.31826  26.37644  1.000 22.35527 ? 494 PHE   B CE1  1 
ATOM   215  C CE2  . PHE   A 1 16  ? 15.30904  15.75049  24.97851  1.000 30.42998 ? 494 PHE   B CE2  1 
ATOM   216  C CZ   . PHE   A 1 16  ? 15.22867  14.91727  26.06592  1.000 24.60211 ? 494 PHE   B CZ   1 
ATOM   217  H H    . PHE   A 1 16  ? 10.26803  17.94273  22.70330  1.000 35.94474 ? 494 PHE   B H    1 
ATOM   218  H HA   . PHE   A 1 16  ? 10.36660  16.48509  24.93255  1.000 31.55279 ? 494 PHE   B HA   1 
ATOM   219  H HB2  . PHE   A 1 16  ? 11.21464  14.80897  23.68611  1.000 34.61068 ? 494 PHE   B HB2  1 
ATOM   220  H HB3  . PHE   A 1 16  ? 12.04474  15.81115  22.77398  1.000 34.61068 ? 494 PHE   B HB3  1 
ATOM   221  H HD1  . PHE   A 1 16  ? 12.10878  14.14534  25.83798  1.000 28.41329 ? 494 PHE   B HD1  1 
ATOM   222  H HD2  . PHE   A 1 16  ? 14.23080  16.55327  23.47773  1.000 36.01488 ? 494 PHE   B HD2  1 
ATOM   223  H HE1  . PHE   A 1 16  ? 13.95058  13.75490  27.11381  1.000 26.78034 ? 494 PHE   B HE1  1 
ATOM   224  H HE2  . PHE   A 1 16  ? 16.11586  16.15805  24.75979  1.000 36.46999 ? 494 PHE   B HE2  1 
ATOM   225  H HZ   . PHE   A 1 16  ? 15.97969  14.75477  26.58982  1.000 29.47655 ? 494 PHE   B HZ   1 
ATOM   226  N N    A CYS   A 1 17  ? 12.08306  17.95390  25.93521  0.492 23.49291 ? 495 CYS   B N    1 
ATOM   227  N N    B CYS   A 1 17  ? 12.07749  17.95339  25.92736  0.508 23.49772 ? 495 CYS   B N    1 
ATOM   228  C CA   A CYS   A 1 17  ? 12.93245  18.98470  26.53015  0.492 22.73804 ? 495 CYS   B CA   1 
ATOM   229  C CA   B CYS   A 1 17  ? 13.08513  18.87338  26.44061  0.508 22.74777 ? 495 CYS   B CA   1 
ATOM   230  C C    A CYS   A 1 17  ? 13.36000  18.51772  27.91786  0.492 21.31259 ? 495 CYS   B C    1 
ATOM   231  C C    B CYS   A 1 17  ? 13.39598  18.47971  27.87640  0.508 21.28904 ? 495 CYS   B C    1 
ATOM   232  O O    A CYS   A 1 17  ? 12.58821  17.84574  28.61287  0.492 20.15804 ? 495 CYS   B O    1 
ATOM   233  O O    B CYS   A 1 17  ? 12.58966  17.83909  28.56108  0.508 20.21526 ? 495 CYS   B O    1 
ATOM   234  C CB   A CYS   A 1 17  ? 12.17530  20.31848  26.61590  0.492 23.06117 ? 495 CYS   B CB   1 
ATOM   235  C CB   B CYS   A 1 17  ? 12.61473  20.31855  26.35502  0.508 23.13988 ? 495 CYS   B CB   1 
ATOM   236  S SG   A CYS   A 1 17  ? 13.07919  21.72940  27.36735  0.492 28.52988 ? 495 CYS   B SG   1 
ATOM   237  S SG   B CYS   A 1 17  ? 11.41754  20.74308  27.59948  0.508 22.96758 ? 495 CYS   B SG   1 
ATOM   238  H H    A CYS   A 1 17  ? 11.79132  17.38198  26.50740  0.492 28.14551 ? 495 CYS   B H    1 
ATOM   239  H H    B CYS   A 1 17  ? 11.70265  17.46176  26.52519  0.508 28.15128 ? 495 CYS   B H    1 
ATOM   240  H HA   A CYS   A 1 17  ? 13.73154  19.11663  25.99635  0.492 27.23966 ? 495 CYS   B HA   1 
ATOM   241  H HA   B CYS   A 1 17  ? 13.90149  18.79444  25.92272  0.508 27.25134 ? 495 CYS   B HA   1 
ATOM   242  H HB2  A CYS   A 1 17  ? 11.93161  20.58437  25.71545  0.492 27.62742 ? 495 CYS   B HB2  1 
ATOM   243  H HB2  B CYS   A 1 17  ? 13.37996  20.90438  26.46518  0.508 27.72187 ? 495 CYS   B HB2  1 
ATOM   244  H HB3  A CYS   A 1 17  ? 11.37650  20.17717  27.14773  0.492 27.62742 ? 495 CYS   B HB3  1 
ATOM   245  H HB3  B CYS   A 1 17  ? 12.20724  20.46473  25.48699  0.508 27.72187 ? 495 CYS   B HB3  1 
ATOM   246  H HG   A CYS   A 1 17  ? 14.06711  21.94851  26.72236  0.492 34.18987 ? 495 CYS   B HG   1 
ATOM   247  H HG   B CYS   A 1 17  ? 10.56255  19.90137  27.62236  0.508 27.51511 ? 495 CYS   B HG   1 
ATOM   248  N N    . MET   A 1 18  ? 14.58825  18.85886  28.30692  1.000 19.67014 ? 496 MET   B N    1 
ATOM   249  C CA   . MET   A 1 18  ? 15.08041  18.64536  29.65491  1.000 20.50539 ? 496 MET   B CA   1 
ATOM   250  C C    . MET   A 1 18  ? 15.12715  19.99344  30.37144  1.000 22.00453 ? 496 MET   B C    1 
ATOM   251  O O    . MET   A 1 18  ? 15.73907  20.94039  29.86923  1.000 22.80619 ? 496 MET   B O    1 
ATOM   252  C CB   . MET   A 1 18  ? 16.47452  18.01319  29.61592  1.000 21.59164 ? 496 MET   B CB   1 
ATOM   253  C CG   . MET   A 1 18  ? 16.60475  16.76296  28.76217  1.000 23.81104 ? 496 MET   B CG   1 
ATOM   254  S SD   . MET   A 1 18  ? 15.99116  15.28015  29.63205  1.000 21.71772 ? 496 MET   B SD   1 
ATOM   255  C CE   . MET   A 1 18  ? 17.28563  15.03994  30.84134  1.000 22.13366 ? 496 MET   B CE   1 
ATOM   256  H H    A MET   A 1 18  ? 15.16725  19.22605  27.78776  0.492 23.55819 ? 496 MET   B H    1 
ATOM   257  H H    B MET   A 1 18  ? 15.16037  19.26368  27.80852  0.508 23.55819 ? 496 MET   B H    1 
ATOM   258  H HA   . MET   A 1 18  ? 14.49116  18.04508  30.13798  1.000 24.56048 ? 496 MET   B HA   1 
ATOM   259  H HB2  . MET   A 1 18  ? 17.09658  18.66885  29.26372  1.000 25.86398 ? 496 MET   B HB2  1 
ATOM   260  H HB3  . MET   A 1 18  ? 16.72476  17.77132  30.52134  1.000 25.86398 ? 496 MET   B HB3  1 
ATOM   261  H HG2  . MET   A 1 18  ? 16.08640  16.87510  27.94999  1.000 28.52726 ? 496 MET   B HG2  1 
ATOM   262  H HG3  . MET   A 1 18  ? 17.53897  16.62171  28.54265  1.000 28.52726 ? 496 MET   B HG3  1 
ATOM   263  H HE1  . MET   A 1 18  ? 17.11524  14.21793  31.32729  1.000 26.51440 ? 496 MET   B HE1  1 
ATOM   264  H HE2  . MET   A 1 18  ? 18.13886  14.98273  30.38348  1.000 26.51440 ? 496 MET   B HE2  1 
ATOM   265  H HE3  . MET   A 1 18  ? 17.28882  15.79187  31.45412  1.000 26.51440 ? 496 MET   B HE3  1 
ATOM   266  N N    . VAL   A 1 19  ? 14.51748  20.07220  31.55117  1.000 19.04243 ? 497 VAL   B N    1 
ATOM   267  C CA   . VAL   A 1 19  ? 14.41731  21.31519  32.29260  1.000 19.62276 ? 497 VAL   B CA   1 
ATOM   268  C C    . VAL   A 1 19  ? 15.25142  21.21248  33.57012  1.000 18.51882 ? 497 VAL   B C    1 
ATOM   269  O O    . VAL   A 1 19  ? 14.94518  20.44391  34.48441  1.000 17.84613 ? 497 VAL   B O    1 
ATOM   270  C CB   . VAL   A 1 19  ? 12.95522  21.66590  32.59907  1.000 18.72984 ? 497 VAL   B CB   1 
ATOM   271  C CG1  . VAL   A 1 19  ? 12.87889  23.04481  33.30575  1.000 22.28142 ? 497 VAL   B CG1  1 
ATOM   272  C CG2  . VAL   A 1 19  ? 12.13389  21.65834  31.33183  1.000 20.29632 ? 497 VAL   B CG2  1 
ATOM   273  H H    . VAL   A 1 19  ? 14.14862  19.40303  31.94582  1.000 22.80493 ? 497 VAL   B H    1 
ATOM   274  H HA   . VAL   A 1 19  ? 14.80373  22.02805  31.76023  1.000 23.50133 ? 497 VAL   B HA   1 
ATOM   275  H HB   . VAL   A 1 19  ? 12.58144  20.99873  33.19579  1.000 22.42983 ? 497 VAL   B HB   1 
ATOM   276  H HG11 . VAL   A 1 19  ? 11.95017  23.31851  33.36464  1.000 26.69172 ? 497 VAL   B HG11 1 
ATOM   277  H HG12 . VAL   A 1 19  ? 13.25730  22.96514  34.19533  1.000 26.69172 ? 497 VAL   B HG12 1 
ATOM   278  H HG13 . VAL   A 1 19  ? 13.38258  23.69288  32.78884  1.000 26.69172 ? 497 VAL   B HG13 1 
ATOM   279  H HG21 . VAL   A 1 19  ? 11.24101  21.98004  31.53227  1.000 24.30960 ? 497 VAL   B HG21 1 
ATOM   280  H HG22 . VAL   A 1 19  ? 12.55562  22.23841  30.67871  1.000 24.30960 ? 497 VAL   B HG22 1 
ATOM   281  H HG23 . VAL   A 1 19  ? 12.08977  20.75183  30.98950  1.000 24.30960 ? 497 VAL   B HG23 1 
ATOM   282  N N    . GLN   A 1 20  ? 16.25575  22.06239  33.67180  1.000 17.81734 ? 498 GLN   B N    1 
ATOM   283  C CA   . GLN   A 1 20  ? 17.08704  22.12750  34.85450  1.000 17.97286 ? 498 GLN   B CA   1 
ATOM   284  C C    . GLN   A 1 20  ? 16.34447  22.73460  36.03069  1.000 20.40875 ? 498 GLN   B C    1 
ATOM   285  O O    . GLN   A 1 20  ? 15.79905  23.84120  35.94541  1.000 19.57587 ? 498 GLN   B O    1 
ATOM   286  C CB   . GLN   A 1 20  ? 18.33192  22.95910  34.51325  1.000 18.91290 ? 498 GLN   B CB   1 
ATOM   287  C CG   . GLN   A 1 20  ? 19.36638  22.97128  35.56165  1.000 21.40168 ? 498 GLN   B CG   1 
ATOM   288  C CD   . GLN   A 1 20  ? 20.62310  23.66096  35.04626  1.000 26.17580 ? 498 GLN   B CD   1 
ATOM   289  O OE1  . GLN   A 1 20  ? 21.32185  23.12337  34.18194  1.000 27.26638 ? 498 GLN   B OE1  1 
ATOM   290  N NE2  . GLN   A 1 20  ? 20.88776  24.85729  35.55053  1.000 25.70969 ? 498 GLN   B NE2  1 
ATOM   291  H H    . GLN   A 1 20  ? 16.48062  22.62210  33.05881  1.000 21.33482 ? 498 GLN   B H    1 
ATOM   292  H HA   . GLN   A 1 20  ? 17.34718  21.23381  35.12754  1.000 21.52144 ? 498 GLN   B HA   1 
ATOM   293  H HB2  . GLN   A 1 20  ? 18.73463  22.59612  33.70891  1.000 22.64949 ? 498 GLN   B HB2  1 
ATOM   294  H HB3  . GLN   A 1 20  ? 18.05784  23.87717  34.36182  1.000 22.64949 ? 498 GLN   B HB3  1 
ATOM   295  H HG2  . GLN   A 1 20  ? 19.04061  23.45582  36.33624  1.000 25.63603 ? 498 GLN   B HG2  1 
ATOM   296  H HG3  . GLN   A 1 20  ? 19.59038  22.06076  35.80997  1.000 25.63603 ? 498 GLN   B HG3  1 
ATOM   297  H HE21 . GLN   A 1 20  ? 20.36152  25.20304  36.13630  1.000 30.80565 ? 498 GLN   B HE21 1 
ATOM   298  H HE22 . GLN   A 1 20  ? 21.58579  25.28805  35.29206  1.000 30.80565 ? 498 GLN   B HE22 1 
ATOM   299  N N    . LEU   A 1 21  ? 16.31190  22.01448  37.12856  1.000 15.47886 ? 499 LEU   B N    1 
ATOM   300  C CA   . LEU   A 1 21  ? 15.61739  22.47853  38.31694  1.000 17.47842 ? 499 LEU   B CA   1 
ATOM   301  C C    . LEU   A 1 21  ? 16.51498  23.35167  39.18286  1.000 18.52186 ? 499 LEU   B C    1 
ATOM   302  O O    . LEU   A 1 21  ? 17.74465  23.23742  39.15700  1.000 18.11786 ? 499 LEU   B O    1 
ATOM   303  C CB   . LEU   A 1 21  ? 15.12659  21.31263  39.16348  1.000 15.68141 ? 499 LEU   B CB   1 
ATOM   304  C CG   . LEU   A 1 21  ? 14.15891  20.33085  38.44145  1.000 15.97466 ? 499 LEU   B CG   1 
ATOM   305  C CD1  . LEU   A 1 21  ? 13.71327  19.26447  39.41629  1.000 17.48071 ? 499 LEU   B CD1  1 
ATOM   306  C CD2  . LEU   A 1 21  ? 12.95870  21.08991  37.87308  1.000 16.66610 ? 499 LEU   B CD2  1 
ATOM   307  H H    . LEU   A 1 21  ? 16.68652  21.24535  37.21631  1.000 18.52865 ? 499 LEU   B H    1 
ATOM   308  H HA   . LEU   A 1 21  ? 14.85500  23.00133  38.02310  1.000 20.92812 ? 499 LEU   B HA   1 
ATOM   309  H HB2  . LEU   A 1 21  ? 15.89726  20.80015  39.45386  1.000 18.77171 ? 499 LEU   B HB2  1 
ATOM   310  H HB3  . LEU   A 1 21  ? 14.65686  21.67028  39.93311  1.000 18.77171 ? 499 LEU   B HB3  1 
ATOM   311  H HG   . LEU   A 1 21  ? 14.61097  19.90177  37.69819  1.000 19.12360 ? 499 LEU   B HG   1 
ATOM   312  H HD11 . LEU   A 1 21  ? 13.10550  18.65805  38.96490  1.000 20.93087 ? 499 LEU   B HD11 1 
ATOM   313  H HD12 . LEU   A 1 21  ? 14.49186  18.77901  39.73098  1.000 20.93087 ? 499 LEU   B HD12 1 
ATOM   314  H HD13 . LEU   A 1 21  ? 13.26322  19.68817  40.16384  1.000 20.93087 ? 499 LEU   B HD13 1 
ATOM   315  H HD21 . LEU   A 1 21  ? 12.29991  20.45037  37.56022  1.000 19.95333 ? 499 LEU   B HD21 1 
ATOM   316  H HD22 . LEU   A 1 21  ? 12.57614  21.64415  38.57121  1.000 19.95333 ? 499 LEU   B HD22 1 
ATOM   317  H HD23 . LEU   A 1 21  ? 13.25665  21.64536  37.13579  1.000 19.95333 ? 499 LEU   B HD23 1 
ATOM   318  N N    . GLU   A 1 22  ? 15.86639  24.21288  40.00225  1.000 19.75348 ? 500 GLU   B N    1 
ATOM   319  C CA   . GLU   A 1 22  ? 16.57558  25.11523  40.93000  1.000 19.68308 ? 500 GLU   B CA   1 
ATOM   320  C C    . GLU   A 1 22  ? 16.54905  24.58665  42.35607  1.000 17.73293 ? 500 GLU   B C    1 
ATOM   321  O O    . GLU   A 1 22  ? 15.46511  24.26771  42.88740  1.000 17.96927 ? 500 GLU   B O    1 
ATOM   322  C CB   . GLU   A 1 22  ? 15.92614  26.50609  40.89084  1.000 18.44334 ? 500 GLU   B CB   1 
ATOM   323  C CG   . GLU   A 1 22  ? 16.25947  27.27213  39.60002  1.000 22.26280 ? 500 GLU   B CG   1 
ATOM   324  C CD   . GLU   A 1 22  ? 17.74920  27.67949  39.53592  1.000 26.66635 ? 500 GLU   B CD   1 
ATOM   325  O OE1  . GLU   A 1 22  ? 18.40720  27.69732  40.59824  1.000 25.34153 ? 500 GLU   B OE1  1 
ATOM   326  O OE2  . GLU   A 1 22  ? 18.25343  27.97146  38.43455  1.000 23.09058 ? 500 GLU   B OE2  1 
ATOM   327  H H    . GLU   A 1 22  ? 15.01062  24.29082  40.03668  1.000 23.65819 ? 500 GLU   B H    1 
ATOM   328  H HA   . GLU   A 1 22  ? 17.50512  25.17702  40.65974  1.000 23.57372 ? 500 GLU   B HA   1 
ATOM   329  H HB2  . GLU   A 1 22  ? 14.96257  26.40766  40.94323  1.000 22.08603 ? 500 GLU   B HB2  1 
ATOM   330  H HB3  . GLU   A 1 22  ? 16.24775  27.02746  41.64293  1.000 22.08603 ? 500 GLU   B HB3  1 
ATOM   331  H HG2  . GLU   A 1 22  ? 16.06654  26.70750  38.83525  1.000 26.66938 ? 500 GLU   B HG2  1 
ATOM   332  H HG3  . GLU   A 1 22  ? 15.72269  28.07910  39.56043  1.000 26.66938 ? 500 GLU   B HG3  1 
ATOM   333  N N    . PRO   A 1 23  ? 17.70981  24.44306  42.99844  1.000 18.89763 ? 501 PRO   B N    1 
ATOM   334  C CA   . PRO   A 1 23  ? 17.71804  24.15595  44.42964  1.000 18.09278 ? 501 PRO   B CA   1 
ATOM   335  C C    . PRO   A 1 23  ? 16.87169  25.17280  45.19047  1.000 20.42338 ? 501 PRO   B C    1 
ATOM   336  O O    . PRO   A 1 23  ? 16.79667  26.35129  44.82522  1.000 20.63863 ? 501 PRO   B O    1 
ATOM   337  C CB   . PRO   A 1 23  ? 19.19917  24.24305  44.80560  1.000 23.59371 ? 501 PRO   B CB   1 
ATOM   338  C CG   . PRO   A 1 23  ? 19.93414  23.91543  43.53970  1.000 20.09399 ? 501 PRO   B CG   1 
ATOM   339  C CD   . PRO   A 1 23  ? 19.06956  24.52668  42.42936  1.000 18.54879 ? 501 PRO   B CD   1 
ATOM   340  H HA   . PRO   A 1 23  ? 17.39596  23.25909  44.61079  1.000 21.66536 ? 501 PRO   B HA   1 
ATOM   341  H HB2  . PRO   A 1 23  ? 19.41160  25.13942  45.10939  1.000 28.26647 ? 501 PRO   B HB2  1 
ATOM   342  H HB3  . PRO   A 1 23  ? 19.40236  23.59969  45.50252  1.000 28.26647 ? 501 PRO   B HB3  1 
ATOM   343  H HG2  . PRO   A 1 23  ? 20.81771  24.31541  43.55425  1.000 24.06680 ? 501 PRO   B HG2  1 
ATOM   344  H HG3  . PRO   A 1 23  ? 20.00698  22.95375  43.43594  1.000 24.06680 ? 501 PRO   B HG3  1 
ATOM   345  H HD2  . PRO   A 1 23  ? 19.32019  25.44845  42.26075  1.000 22.21257 ? 501 PRO   B HD2  1 
ATOM   346  H HD3  . PRO   A 1 23  ? 19.13690  24.00964  41.61141  1.000 22.21257 ? 501 PRO   B HD3  1 
ATOM   347  N N    . GLY   A 1 24  ? 16.25416  24.70795  46.26401  1.000 21.63790 ? 502 GLY   B N    1 
ATOM   348  C CA   . GLY   A 1 24  ? 15.32946  25.51873  47.03391  1.000 24.47315 ? 502 GLY   B CA   1 
ATOM   349  C C    . GLY   A 1 24  ? 13.87138  25.40116  46.60703  1.000 24.12701 ? 502 GLY   B C    1 
ATOM   350  O O    . GLY   A 1 24  ? 12.97827  25.66770  47.40367  1.000 25.40743 ? 502 GLY   B O    1 
ATOM   351  H H    . GLY   A 1 24  ? 16.35712  23.91123  46.57099  1.000 25.91949 ? 502 GLY   B H    1 
ATOM   352  H HA2  . GLY   A 1 24  ? 15.38735  25.25670  47.96605  1.000 29.32179 ? 502 GLY   B HA2  1 
ATOM   353  H HA3  . GLY   A 1 24  ? 15.58834  26.44986  46.95094  1.000 29.32179 ? 502 GLY   B HA3  1 
ATOM   354  N N    . GLN   A 1 25  ? 13.61304  25.04597  45.36418  1.000 20.13138 ? 503 GLN   B N    1 
ATOM   355  C CA   . GLN   A 1 25  ? 12.25280  24.72896  44.96406  1.000 21.66470 ? 503 GLN   B CA   1 
ATOM   356  C C    . GLN   A 1 25  ? 11.89123  23.36033  45.53003  1.000 19.99972 ? 503 GLN   B C    1 
ATOM   357  O O    . GLN   A 1 25  ? 12.74426  22.45826  45.64517  1.000 17.20384 ? 503 GLN   B O    1 
ATOM   358  C CB   . GLN   A 1 25  ? 12.12369  24.70496  43.44166  1.000 22.50737 ? 503 GLN   B CB   1 
ATOM   359  C CG   . GLN   A 1 25  ? 12.21475  26.09725  42.80643  1.000 27.02525 ? 503 GLN   B CG   1 
ATOM   360  C CD   . GLN   A 1 25  ? 11.00160  26.96784  43.11029  1.000 36.21319 ? 503 GLN   B CD   1 
ATOM   361  O OE1  . GLN   A 1 25  ? 10.14160  26.60773  43.90733  1.000 42.09499 ? 503 GLN   B OE1  1 
ATOM   362  N NE2  . GLN   A 1 25  ? 10.93176  28.11915  42.46848  1.000 41.07991 ? 503 GLN   B NE2  1 
ATOM   363  H H    . GLN   A 1 25  ? 14.19879  24.98060  44.73790  1.000 24.11167 ? 503 GLN   B H    1 
ATOM   364  H HA   . GLN   A 1 25  ? 11.63696  25.40129  45.29514  1.000 25.95166 ? 503 GLN   B HA   1 
ATOM   365  H HB2  . GLN   A 1 25  ? 12.83854  24.16183  43.07439  1.000 26.96286 ? 503 GLN   B HB2  1 
ATOM   366  H HB3  . GLN   A 1 25  ? 11.26319  24.32465  43.20542  1.000 26.96286 ? 503 GLN   B HB3  1 
ATOM   367  H HG2  . GLN   A 1 25  ? 13.00133  26.54969  43.14921  1.000 32.38432 ? 503 GLN   B HG2  1 
ATOM   368  H HG3  . GLN   A 1 25  ? 12.28059  26.00109  41.84346  1.000 32.38432 ? 503 GLN   B HG3  1 
ATOM   369  H HE21 . GLN   A 1 25  ? 11.55107  28.34089  41.91451  1.000 49.24991 ? 503 GLN   B HE21 1 
ATOM   370  H HE22 . GLN   A 1 25  ? 10.26695  28.64753  42.60429  1.000 49.24991 ? 503 GLN   B HE22 1 
ATOM   371  N N    . SER   A 1 26  ? 10.61459  23.20941  45.89338  1.000 18.34617 ? 504 SER   B N    1 
ATOM   372  C CA   . SER   A 1 26  ? 10.19575  21.95060  46.51046  1.000 16.86395 ? 504 SER   B CA   1 
ATOM   373  C C    . SER   A 1 26  ? 10.47125  20.76639  45.56922  1.000 15.99448 ? 504 SER   B C    1 
ATOM   374  O O    . SER   A 1 26  ? 10.80088  19.65523  46.01710  1.000 16.59332 ? 504 SER   B O    1 
ATOM   375  C CB   . SER   A 1 26  ? 8.69198   22.01860  46.84950  1.000 21.23751 ? 504 SER   B CB   1 
ATOM   376  O OG   . SER   A 1 26  ? 8.26058   20.80515  47.41646  1.000 19.71407 ? 504 SER   B OG   1 
ATOM   377  H H    . SER   A 1 26  ? 9.99502   23.79804  45.79723  1.000 21.96942 ? 504 SER   B H    1 
ATOM   378  H HA   . SER   A 1 26  ? 10.69255  21.81410  47.33232  1.000 20.19076 ? 504 SER   B HA   1 
ATOM   379  H HB2  . SER   A 1 26  ? 8.54193   22.73653  47.48428  1.000 25.43903 ? 504 SER   B HB2  1 
ATOM   380  H HB3  . SER   A 1 26  ? 8.19046   22.18481  46.03601  1.000 25.43903 ? 504 SER   B HB3  1 
ATOM   381  H HG   . SER   A 1 26  ? 7.44224   20.84908  47.60083  1.000 23.61090 ? 504 SER   B HG   1 
ATOM   382  N N    . GLU   A 1 27  ? 10.26272  20.96536  44.27646  1.000 16.39059 ? 505 GLU   B N    1 
ATOM   383  C CA   . GLU   A 1 27  ? 10.43334  19.86721  43.32262  1.000 16.57118 ? 505 GLU   B CA   1 
ATOM   384  C C    . GLU   A 1 27  ? 11.87277  19.33970  43.34184  1.000 16.94485 ? 505 GLU   B C    1 
ATOM   385  O O    . GLU   A 1 27  ? 12.09585  18.12965  43.33642  1.000 15.81939 ? 505 GLU   B O    1 
ATOM   386  C CB   . GLU   A 1 27  ? 10.05469  20.33683  41.92387  1.000 17.05286 ? 505 GLU   B CB   1 
ATOM   387  C CG   . GLU   A 1 27  ? 10.02887  19.19902  40.90348  1.000 17.30535 ? 505 GLU   B CG   1 
ATOM   388  C CD   . GLU   A 1 27  ? 9.60671   19.69010  39.52831  1.000 19.85239 ? 505 GLU   B CD   1 
ATOM   389  O OE1  . GLU   A 1 27  ? 9.51081   20.91845  39.32452  1.000 19.24714 ? 505 GLU   B OE1  1 
ATOM   390  O OE2  . GLU   A 1 27  ? 9.36931   18.85217  38.65220  1.000 17.99397 ? 505 GLU   B OE2  1 
ATOM   391  H H    . GLU   A 1 27  ? 10.02514  21.71322  43.92454  1.000 19.62272 ? 505 GLU   B H    1 
ATOM   392  H HA   . GLU   A 1 27  ? 9.84242   19.13824  43.56822  1.000 19.83943 ? 505 GLU   B HA   1 
ATOM   393  H HB2  . GLU   A 1 27  ? 9.17018   20.73393  41.95310  1.000 20.41745 ? 505 GLU   B HB2  1 
ATOM   394  H HB3  . GLU   A 1 27  ? 10.70335  20.99326  41.62513  1.000 20.41745 ? 505 GLU   B HB3  1 
ATOM   395  H HG2  . GLU   A 1 27  ? 10.91609  18.81376  40.83047  1.000 20.72044 ? 505 GLU   B HG2  1 
ATOM   396  H HG3  . GLU   A 1 27  ? 9.39644   18.52299  41.19315  1.000 20.72044 ? 505 GLU   B HG3  1 
ATOM   397  N N    . TYR   A 1 28  ? 12.85888  20.23947  43.36085  1.000 13.85002 ? 506 TYR   B N    1 
ATOM   398  C CA   . TYR   A 1 28  ? 14.25654  19.82699  43.46432  1.000 15.51687 ? 506 TYR   B CA   1 
ATOM   399  C C    . TYR   A 1 28  ? 14.54374  19.21218  44.82496  1.000 15.84459 ? 506 TYR   B C    1 
ATOM   400  O O    . TYR   A 1 28  ? 15.17299  18.14369  44.92947  1.000 15.95747 ? 506 TYR   B O    1 
ATOM   401  C CB   . TYR   A 1 28  ? 15.16350  21.04259  43.21209  1.000 15.63848 ? 506 TYR   B CB   1 
ATOM   402  C CG   . TYR   A 1 28  ? 16.63636  20.78430  43.32264  1.000 15.47237 ? 506 TYR   B CG   1 
ATOM   403  C CD1  . TYR   A 1 28  ? 17.22224  20.53303  44.55918  1.000 16.51504 ? 506 TYR   B CD1  1 
ATOM   404  C CD2  . TYR   A 1 28  ? 17.44988  20.80256  42.19555  1.000 15.15324 ? 506 TYR   B CD2  1 
ATOM   405  C CE1  . TYR   A 1 28  ? 18.62696  20.28780  44.65251  1.000 16.53351 ? 506 TYR   B CE1  1 
ATOM   406  C CE2  . TYR   A 1 28  ? 18.80984  20.55448  42.29624  1.000 14.86561 ? 506 TYR   B CE2  1 
ATOM   407  C CZ   . TYR   A 1 28  ? 19.36955  20.32606  43.51192  1.000 15.59367 ? 506 TYR   B CZ   1 
ATOM   408  O OH   . TYR   A 1 28  ? 20.73062  20.10167  43.59473  1.000 19.08826 ? 506 TYR   B OH   1 
ATOM   409  H H    . TYR   A 1 28  ? 12.74502  21.09069  43.31534  1.000 16.57403 ? 506 TYR   B H    1 
ATOM   410  H HA   . TYR   A 1 28  ? 14.44629  19.15608  42.78996  1.000 18.57426 ? 506 TYR   B HA   1 
ATOM   411  H HB2  . TYR   A 1 28  ? 14.99435  21.36812  42.31414  1.000 18.72019 ? 506 TYR   B HB2  1 
ATOM   412  H HB3  . TYR   A 1 28  ? 14.94146  21.72855  43.86098  1.000 18.72019 ? 506 TYR   B HB3  1 
ATOM   413  H HD1  . TYR   A 1 28  ? 16.69812  20.52463  45.32738  1.000 19.77207 ? 506 TYR   B HD1  1 
ATOM   414  H HD2  . TYR   A 1 28  ? 17.07678  20.98360  41.36313  1.000 18.13790 ? 506 TYR   B HD2  1 
ATOM   415  H HE1  . TYR   A 1 28  ? 19.02473  20.10628  45.47332  1.000 19.79423 ? 506 TYR   B HE1  1 
ATOM   416  H HE2  . TYR   A 1 28  ? 19.33874  20.54448  41.53134  1.000 17.79275 ? 506 TYR   B HE2  1 
ATOM   417  H HH   . TYR   A 1 28  ? 20.94699  19.93811  44.38974  1.000 22.85993 ? 506 TYR   B HH   1 
ATOM   418  N N    . ASN   A 1 29  ? 14.08201  19.86094  45.89372  1.000 16.84319 ? 507 ASN   B N    1 
ATOM   419  C CA   . ASN   A 1 29  ? 14.48083  19.41838  47.22590  1.000 16.46730 ? 507 ASN   B CA   1 
ATOM   420  C C    . ASN   A 1 29  ? 13.91274  18.05271  47.56447  1.000 17.97245 ? 507 ASN   B C    1 
ATOM   421  O O    . ASN   A 1 29  ? 14.57558  17.24109  48.21206  1.000 18.25889 ? 507 ASN   B O    1 
ATOM   422  C CB   . ASN   A 1 29  ? 14.06387  20.44677  48.27308  1.000 19.41481 ? 507 ASN   B CB   1 
ATOM   423  C CG   . ASN   A 1 29  ? 14.96150  21.66325  48.29996  1.000 25.93377 ? 507 ASN   B CG   1 
ATOM   424  O OD1  . ASN   A 1 29  ? 15.76077  21.87983  47.39637  1.000 25.18352 ? 507 ASN   B OD1  1 
ATOM   425  N ND2  . ASN   A 1 29  ? 14.83199  22.47269  49.34493  1.000 30.90728 ? 507 ASN   B ND2  1 
ATOM   426  H H    . ASN   A 1 29  ? 13.55327  20.53893  45.87483  1.000 20.16584 ? 507 ASN   B H    1 
ATOM   427  H HA   . ASN   A 1 29  ? 15.44802  19.34649  47.24227  1.000 19.71478 ? 507 ASN   B HA   1 
ATOM   428  H HB2  . ASN   A 1 29  ? 13.16173  20.74570  48.07899  1.000 23.25178 ? 507 ASN   B HB2  1 
ATOM   429  H HB3  . ASN   A 1 29  ? 14.09495  20.03343  49.15006  1.000 23.25178 ? 507 ASN   B HB3  1 
ATOM   430  H HD21 . ASN   A 1 29  ? 15.32040  23.17793  49.40570  1.000 37.04275 ? 507 ASN   B HD21 1 
ATOM   431  H HD22 . ASN   A 1 29  ? 14.25972  22.29158  49.96081  1.000 37.04275 ? 507 ASN   B HD22 1 
ATOM   432  N N    . THR   A 1 30  ? 12.69908  17.74160  47.10644  1.000 16.38954 ? 508 THR   B N    1 
ATOM   433  C CA   A THR   A 1 30  ? 12.13080  16.43011  47.41579  0.480 19.44539 ? 508 THR   B CA   1 
ATOM   434  C CA   B THR   A 1 30  ? 12.13329  16.42962  47.41385  0.520 19.47207 ? 508 THR   B CA   1 
ATOM   435  C C    . THR   A 1 30  ? 12.91581  15.30593  46.73787  1.000 18.12205 ? 508 THR   B C    1 
ATOM   436  O O    . THR   A 1 30  ? 13.13205  14.23919  47.33499  1.000 18.49859 ? 508 THR   B O    1 
ATOM   437  C CB   A THR   A 1 30  ? 10.65929  16.37168  47.00013  0.480 19.95228 ? 508 THR   B CB   1 
ATOM   438  C CB   B THR   A 1 30  ? 10.66220  16.39857  47.00415  0.520 19.85065 ? 508 THR   B CB   1 
ATOM   439  O OG1  A THR   A 1 30  ? 10.07077  15.14884  47.47360  0.480 20.59783 ? 508 THR   B OG1  1 
ATOM   440  O OG1  B THR   A 1 30  ? 9.98265   17.42621  47.73900  0.520 22.47912 ? 508 THR   B OG1  1 
ATOM   441  C CG2  A THR   A 1 30  ? 10.51634  16.39371  45.49418  0.480 19.27556 ? 508 THR   B CG2  1 
ATOM   442  C CG2  B THR   A 1 30  ? 10.05224  15.02133  47.28406  0.520 20.66362 ? 508 THR   B CG2  1 
ATOM   443  H H    A THR   A 1 30  ? 12.19999  18.25491  46.62997  0.480 19.62146 ? 508 THR   B H    1 
ATOM   444  H H    B THR   A 1 30  ? 12.19916  18.25529  46.63126  0.520 19.62146 ? 508 THR   B H    1 
ATOM   445  H HA   A THR   A 1 30  ? 12.17758  16.29872  48.37571  0.480 23.28848 ? 508 THR   B HA   1 
ATOM   446  H HA   B THR   A 1 30  ? 12.18408  16.27951  48.37082  0.520 23.32050 ? 508 THR   B HA   1 
ATOM   447  H HB   A THR   A 1 30  ? 10.20376  17.14137  47.37560  0.480 23.89675 ? 508 THR   B HB   1 
ATOM   448  H HB   B THR   A 1 30  ? 10.55791  16.55674  46.05283  0.520 23.77480 ? 508 THR   B HB   1 
ATOM   449  H HG1  A THR   A 1 30  ? 9.26378   15.11048  47.24359  0.480 24.67141 ? 508 THR   B HG1  1 
ATOM   450  H HG1  B THR   A 1 30  ? 10.31341  18.17648  47.55652  0.520 26.92896 ? 508 THR   B HG1  1 
ATOM   451  H HG21 A THR   A 1 30  ? 9.59660   16.58301  45.25097  0.480 23.08469 ? 508 THR   B HG21 1 
ATOM   452  H HG21 B THR   A 1 30  ? 9.08546   15.06741  47.21988  0.520 24.75036 ? 508 THR   B HG21 1 
ATOM   453  H HG22 A THR   A 1 30  ? 11.08930  17.07927  45.11653  0.480 23.08469 ? 508 THR   B HG22 1 
ATOM   454  H HG22 B THR   A 1 30  ? 10.38017  14.37584  46.63854  0.520 24.75036 ? 508 THR   B HG22 1 
ATOM   455  H HG23 A THR   A 1 30  ? 10.76906  15.53334  45.12432  0.480 23.08469 ? 508 THR   B HG23 1 
ATOM   456  H HG23 B THR   A 1 30  ? 10.29482  14.72604  48.17561  0.520 24.75036 ? 508 THR   B HG23 1 
ATOM   457  N N    . ILE   A 1 31  ? 13.35010  15.51998  45.49562  1.000 16.52867 ? 509 ILE   B N    1 
ATOM   458  C CA   . ILE   A 1 31  ? 14.17640  14.52212  44.83300  1.000 17.25524 ? 509 ILE   B CA   1 
ATOM   459  C C    . ILE   A 1 31  ? 15.52961  14.42827  45.52283  1.000 17.15685 ? 509 ILE   B C    1 
ATOM   460  O O    . ILE   A 1 31  ? 16.05251  13.33281  45.76813  1.000 17.42977 ? 509 ILE   B O    1 
ATOM   461  C CB   . ILE   A 1 31  ? 14.32702  14.85314  43.34009  1.000 15.70679 ? 509 ILE   B CB   1 
ATOM   462  C CG1  . ILE   A 1 31  ? 12.97623  14.83634  42.63732  1.000 17.91752 ? 509 ILE   B CG1  1 
ATOM   463  C CG2  . ILE   A 1 31  ? 15.31523  13.94175  42.69151  1.000 13.74737 ? 509 ILE   B CG2  1 
ATOM   464  C CD1  . ILE   A 1 31  ? 12.19265  13.51138  42.74134  1.000 17.12730 ? 509 ILE   B CD1  1 
ATOM   465  H H    . ILE   A 1 31  ? 13.18236  16.22108  45.02665  1.000 19.78842 ? 509 ILE   B H    1 
ATOM   466  H HA   . ILE   A 1 31  ? 13.73678  13.66014  44.90098  1.000 20.66030 ? 509 ILE   B HA   1 
ATOM   467  H HB   . ILE   A 1 31  ? 14.67405  15.75555  43.26177  1.000 18.80217 ? 509 ILE   B HB   1 
ATOM   468  H HG12 . ILE   A 1 31  ? 12.42155  15.53135  43.02488  1.000 21.45504 ? 509 ILE   B HG12 1 
ATOM   469  H HG13 . ILE   A 1 31  ? 13.12008  15.01380  41.69461  1.000 21.45504 ? 509 ILE   B HG13 1 
ATOM   470  H HG21 . ILE   A 1 31  ? 15.20027  13.98466  41.72930  1.000 16.45086 ? 509 ILE   B HG21 1 
ATOM   471  H HG22 . ILE   A 1 31  ? 16.21129  14.22602  42.93059  1.000 16.45086 ? 509 ILE   B HG22 1 
ATOM   472  H HG23 . ILE   A 1 31  ? 15.16137  13.03609  43.00296  1.000 16.45086 ? 509 ILE   B HG23 1 
ATOM   473  H HD11 . ILE   A 1 31  ? 11.43895  13.54151  42.13149  1.000 20.50677 ? 509 ILE   B HD11 1 
ATOM   474  H HD12 . ILE   A 1 31  ? 12.78073  12.77727  42.50441  1.000 20.50677 ? 509 ILE   B HD12 1 
ATOM   475  H HD13 . ILE   A 1 31  ? 11.87711  13.40176  43.65201  1.000 20.50677 ? 509 ILE   B HD13 1 
ATOM   476  N N    . LYS   A 1 32  ? 16.13300  15.56893  45.83359  1.000 15.61041 ? 510 LYS   B N    1 
ATOM   477  C CA   . LYS   A 1 32  ? 17.40322  15.53784  46.56519  1.000 17.95026 ? 510 LYS   B CA   1 
ATOM   478  C C    . LYS   A 1 32  ? 17.26051  14.74444  47.86906  1.000 19.12991 ? 510 LYS   B C    1 
ATOM   479  O O    . LYS   A 1 32  ? 18.09281  13.87899  48.18096  1.000 19.93000 ? 510 LYS   B O    1 
ATOM   480  C CB   . LYS   A 1 32  ? 17.88581  16.95630  46.84235  1.000 20.25498 ? 510 LYS   B CB   1 
ATOM   481  C CG   . LYS   A 1 32  ? 19.10844  17.00285  47.76658  1.000 21.79986 ? 510 LYS   B CG   1 
ATOM   482  C CD   . LYS   A 1 32  ? 19.78637  18.36261  47.70901  1.000 29.23087 ? 510 LYS   B CD   1 
ATOM   483  C CE   . LYS   A 1 32  ? 21.08676  18.38010  48.54358  1.000 37.44901 ? 510 LYS   B CE   1 
ATOM   484  N NZ   . LYS   A 1 32  ? 20.81131  18.08077  49.97938  1.000 42.91873 ? 510 LYS   B NZ   1 
ATOM   485  H H    . LYS   A 1 32  ? 15.84083  16.35440  45.64054  1.000 18.68651 ? 510 LYS   B H    1 
ATOM   486  H HA   . LYS   A 1 32  ? 18.07261  15.10062  46.01596  1.000 21.49433 ? 510 LYS   B HA   1 
ATOM   487  H HB2  . LYS   A 1 32  ? 18.12932  17.37574  46.00230  1.000 24.25999 ? 510 LYS   B HB2  1 
ATOM   488  H HB3  . LYS   A 1 32  ? 17.17029  17.45492  47.26698  1.000 24.25999 ? 510 LYS   B HB3  1 
ATOM   489  H HG2  . LYS   A 1 32  ? 18.82865  16.83824  48.68065  1.000 26.11384 ? 510 LYS   B HG2  1 
ATOM   490  H HG3  . LYS   A 1 32  ? 19.74872  16.32907  47.48917  1.000 26.11384 ? 510 LYS   B HG3  1 
ATOM   491  H HD2  . LYS   A 1 32  ? 20.01139  18.57116  46.78881  1.000 35.03106 ? 510 LYS   B HD2  1 
ATOM   492  H HD3  . LYS   A 1 32  ? 19.18626  19.03657  48.06472  1.000 35.03106 ? 510 LYS   B HD3  1 
ATOM   493  H HE2  . LYS   A 1 32  ? 21.69757  17.70822  48.20244  1.000 44.89283 ? 510 LYS   B HE2  1 
ATOM   494  H HE3  . LYS   A 1 32  ? 21.49432  19.25848  48.48665  1.000 44.89283 ? 510 LYS   B HE3  1 
ATOM   495  H HZ1  . LYS   A 1 32  ? 20.23899  18.67667  50.31020  1.000 51.45649 ? 510 LYS   B HZ1  1 
ATOM   496  H HZ2  . LYS   A 1 32  ? 20.45921  17.26723  50.05861  1.000 51.45649 ? 510 LYS   B HZ2  1 
ATOM   497  H HZ3  . LYS   A 1 32  ? 21.56719  18.11523  50.44795  1.000 51.45649 ? 510 LYS   B HZ3  1 
ATOM   498  N N    . ASP   A 1 33  ? 16.19945  15.02359  48.63839  1.000 19.84889 ? 511 ASP   B N    1 
ATOM   499  C CA   . ASP   A 1 33  ? 15.99342  14.30235  49.89361  1.000 20.57178 ? 511 ASP   B CA   1 
ATOM   500  C C    . ASP   A 1 33  ? 15.81932  12.80414  49.65612  1.000 21.48896 ? 511 ASP   B C    1 
ATOM   501  O O    . ASP   A 1 33  ? 16.33831  11.97681  50.41803  1.000 21.00131 ? 511 ASP   B O    1 
ATOM   502  C CB   . ASP   A 1 33  ? 14.77876  14.85054  50.64770  1.000 23.00327 ? 511 ASP   B CB   1 
ATOM   503  C CG   . ASP   A 1 33  ? 15.00972  16.27171  51.15193  1.000 28.21898 ? 511 ASP   B CG   1 
ATOM   504  O OD1  . ASP   A 1 33  ? 16.17936  16.74884  51.12682  1.000 26.92862 ? 511 ASP   B OD1  1 
ATOM   505  O OD2  . ASP   A 1 33  ? 14.02449  16.89683  51.56926  1.000 31.08052 ? 511 ASP   B OD2  1 
ATOM   506  H H    . ASP   A 1 33  ? 15.59957  15.61285  48.45808  1.000 23.77268 ? 511 ASP   B H    1 
ATOM   507  H HA   . ASP   A 1 33  ? 16.77878  14.44142  50.44567  1.000 24.64015 ? 511 ASP   B HA   1 
ATOM   508  H HB2  . ASP   A 1 33  ? 14.01260  14.86113  50.05289  1.000 27.55793 ? 511 ASP   B HB2  1 
ATOM   509  H HB3  . ASP   A 1 33  ? 14.59653  14.28355  51.41335  1.000 27.55793 ? 511 ASP   B HB3  1 
ATOM   510  N N    . LYS   A 1 34  ? 15.04127  12.43678  48.63799  1.000 21.26963 ? 512 LYS   B N    1 
ATOM   511  C CA   . LYS   A 1 34  ? 14.83185  11.01976  48.34835  1.000 20.60508 ? 512 LYS   B CA   1 
ATOM   512  C C    . LYS   A 1 34  ? 16.15352  10.34606  48.02015  1.000 19.87302 ? 512 LYS   B C    1 
ATOM   513  O O    . LYS   A 1 34  ? 16.41073  9.21952   48.45388  1.000 22.48707 ? 512 LYS   B O    1 
ATOM   514  C CB   . LYS   A 1 34  ? 13.83248  10.87822  47.20134  1.000 20.61281 ? 512 LYS   B CB   1 
ATOM   515  C CG   . LYS   A 1 34  ? 13.28270  9.47052   47.00283  1.000 32.65466 ? 512 LYS   B CG   1 
ATOM   516  C CD   . LYS   A 1 34  ? 12.45237  9.40280   45.71417  1.000 41.41893 ? 512 LYS   B CD   1 
ATOM   517  C CE   . LYS   A 1 34  ? 11.93510  7.98060   45.42222  1.000 29.85767 ? 512 LYS   B CE   1 
ATOM   518  N NZ   . LYS   A 1 34  ? 10.88328  7.59480   46.37718  1.000 27.67656 ? 512 LYS   B NZ   1 
ATOM   519  H H    . LYS   A 1 34  ? 14.63092  12.97728  48.10971  1.000 25.47758 ? 512 LYS   B H    1 
ATOM   520  H HA   . LYS   A 1 34  ? 14.45513  10.57273  49.12240  1.000 24.68011 ? 512 LYS   B HA   1 
ATOM   521  H HB2  . LYS   A 1 34  ? 13.07904  11.46379  47.37555  1.000 24.68938 ? 512 LYS   B HB2  1 
ATOM   522  H HB3  . LYS   A 1 34  ? 14.27154  11.13894  46.37663  1.000 24.68938 ? 512 LYS   B HB3  1 
ATOM   523  H HG2  . LYS   A 1 34  ? 14.01686  8.84048   46.93239  1.000 39.13960 ? 512 LYS   B HG2  1 
ATOM   524  H HG3  . LYS   A 1 34  ? 12.71329  9.23405   47.75166  1.000 39.13960 ? 512 LYS   B HG3  1 
ATOM   525  H HD2  . LYS   A 1 34  ? 11.68535  9.99049   45.79909  1.000 49.65673 ? 512 LYS   B HD2  1 
ATOM   526  H HD3  . LYS   A 1 34  ? 13.00316  9.68217   44.96618  1.000 49.65673 ? 512 LYS   B HD3  1 
ATOM   527  H HE2  . LYS   A 1 34  ? 11.56327  7.94966   44.52685  1.000 35.78322 ? 512 LYS   B HE2  1 
ATOM   528  H HE3  . LYS   A 1 34  ? 12.66688  7.34860   45.49958  1.000 35.78322 ? 512 LYS   B HE3  1 
ATOM   529  H HZ1  . LYS   A 1 34  ? 10.59491  6.77241   46.19656  1.000 33.16589 ? 512 LYS   B HZ1  1 
ATOM   530  H HZ2  . LYS   A 1 34  ? 11.20422  7.61256   47.20711  1.000 33.16589 ? 512 LYS   B HZ2  1 
ATOM   531  H HZ3  . LYS   A 1 34  ? 10.19822  8.16009   46.32026  1.000 33.16589 ? 512 LYS   B HZ3  1 
ATOM   532  N N    . PHE   A 1 35  ? 17.01012  11.04000  47.27604  1.000 18.43846 ? 513 PHE   B N    1 
ATOM   533  C CA   . PHE   A 1 35  ? 18.30948  10.51267  46.89401  1.000 17.46702 ? 513 PHE   B CA   1 
ATOM   534  C C    . PHE   A 1 35  ? 19.24512  10.43068  48.09199  1.000 18.94002 ? 513 PHE   B C    1 
ATOM   535  O O    . PHE   A 1 35  ? 19.82091  9.36622   48.37867  1.000 19.67014 ? 513 PHE   B O    1 
ATOM   536  C CB   . PHE   A 1 35  ? 18.87751  11.40997  45.79319  1.000 16.12646 ? 513 PHE   B CB   1 
ATOM   537  C CG   . PHE   A 1 35  ? 20.29395  11.12654  45.41473  1.000 18.65913 ? 513 PHE   B CG   1 
ATOM   538  C CD1  . PHE   A 1 35  ? 20.59365  10.24461  44.39494  1.000 17.74475 ? 513 PHE   B CD1  1 
ATOM   539  C CD2  . PHE   A 1 35  ? 21.34389  11.78779  46.04804  1.000 17.87160 ? 513 PHE   B CD2  1 
ATOM   540  C CE1  . PHE   A 1 35  ? 21.90208  10.00937  44.03032  1.000 18.65517 ? 513 PHE   B CE1  1 
ATOM   541  C CE2  . PHE   A 1 35  ? 22.65574  11.55261  45.69174  1.000 19.32560 ? 513 PHE   B CE2  1 
ATOM   542  C CZ   . PHE   A 1 35  ? 22.93567  10.66111  44.66757  1.000 18.05842 ? 513 PHE   B CZ   1 
ATOM   543  H H    . PHE   A 1 35  ? 16.85883  11.83144  46.97550  1.000 22.08016 ? 513 PHE   B H    1 
ATOM   544  H HA   . PHE   A 1 35  ? 18.22164  9.61035   46.54903  1.000 20.91444 ? 513 PHE   B HA   1 
ATOM   545  H HB2  . PHE   A 1 35  ? 18.33593  11.29826  44.99625  1.000 19.30577 ? 513 PHE   B HB2  1 
ATOM   546  H HB3  . PHE   A 1 35  ? 18.83632  12.33059  46.09594  1.000 19.30577 ? 513 PHE   B HB3  1 
ATOM   547  H HD1  . PHE   A 1 35  ? 19.90566  9.80494   43.94968  1.000 21.24771 ? 513 PHE   B HD1  1 
ATOM   548  H HD2  . PHE   A 1 35  ? 21.15699  12.39910  46.72352  1.000 21.39993 ? 513 PHE   B HD2  1 
ATOM   549  H HE1  . PHE   A 1 35  ? 22.08896  9.40547   43.34820  1.000 22.34022 ? 513 PHE   B HE1  1 
ATOM   550  H HE2  . PHE   A 1 35  ? 23.34709  11.98881  46.13522  1.000 23.14474 ? 513 PHE   B HE2  1 
ATOM   551  H HZ   . PHE   A 1 35  ? 23.81593  10.50379  44.41205  1.000 21.62412 ? 513 PHE   B HZ   1 
ATOM   552  N N    . THR   A 1 36  ? 19.36502  11.52760  48.83712  1.000 19.68667 ? 514 THR   B N    1 
ATOM   553  C CA   . THR   A 1 36  ? 20.32766  11.58089  49.93335  1.000 20.74452 ? 514 THR   B CA   1 
ATOM   554  C C    . THR   A 1 36  ? 19.94523  10.67947  51.07928  1.000 22.86682 ? 514 THR   B C    1 
ATOM   555  O O    . THR   A 1 36  ? 20.79981  10.35962  51.90776  1.000 25.44523 ? 514 THR   B O    1 
ATOM   556  C CB   . THR   A 1 36  ? 20.47796  13.01228  50.45982  1.000 23.15945 ? 514 THR   B CB   1 
ATOM   557  O OG1  . THR   A 1 36  ? 19.22701  13.43668  50.99674  1.000 28.48353 ? 514 THR   B OG1  1 
ATOM   558  C CG2  . THR   A 1 36  ? 20.90459  13.92319  49.35694  1.000 20.77580 ? 514 THR   B CG2  1 
ATOM   559  H H    . THR   A 1 36  ? 18.90581  12.24677  48.72980  1.000 23.57802 ? 514 THR   B H    1 
ATOM   560  H HA   . THR   A 1 36  ? 21.18623  11.29506  49.58398  1.000 24.84743 ? 514 THR   B HA   1 
ATOM   561  H HB   . THR   A 1 36  ? 21.15415  13.05208  51.15414  1.000 27.74536 ? 514 THR   B HB   1 
ATOM   562  H HG1  . THR   A 1 36  ? 19.29307  14.21909  51.29519  1.000 34.13425 ? 514 THR   B HG1  1 
ATOM   563  H HG21 . THR   A 1 36  ? 20.76767  14.84726  49.61818  1.000 24.88498 ? 514 THR   B HG21 1 
ATOM   564  H HG22 . THR   A 1 36  ? 21.84463  13.78779  49.15972  1.000 24.88498 ? 514 THR   B HG22 1 
ATOM   565  H HG23 . THR   A 1 36  ? 20.38593  13.74190  48.55754  1.000 24.88498 ? 514 THR   B HG23 1 
ATOM   566  N N    . ARG   A 1 37  ? 18.68567  10.25367  51.14865  1.000 22.88072 ? 515 ARG   B N    1 
ATOM   567  C CA   . ARG   A 1 37  ? 18.26027  9.34177   52.20765  1.000 23.57095 ? 515 ARG   B CA   1 
ATOM   568  C C    . ARG   A 1 37  ? 19.17487  8.13202   52.28293  1.000 26.40996 ? 515 ARG   B C    1 
ATOM   569  O O    . ARG   A 1 37  ? 19.46276  7.63078   53.37559  1.000 28.96600 ? 515 ARG   B O    1 
ATOM   570  C CB   . ARG   A 1 37  ? 16.81240  8.90469   51.95663  1.000 30.67500 ? 515 ARG   B CB   1 
ATOM   571  C CG   . ARG   A 1 37  ? 16.02033  8.62194   53.20871  1.000 43.77529 ? 515 ARG   B CG   1 
ATOM   572  C CD   . ARG   A 1 37  ? 14.64681  8.03210   52.88968  1.000 48.53419 ? 515 ARG   B CD   1 
ATOM   573  N NE   . ARG   A 1 37  ? 14.76521  6.77682   52.15487  1.000 55.36357 ? 515 ARG   B NE   1 
ATOM   574  C CZ   . ARG   A 1 37  ? 14.90754  5.58286   52.71974  1.000 56.90132 ? 515 ARG   B CZ   1 
ATOM   575  N NH1  . ARG   A 1 37  ? 14.92012  5.43515   54.03732  1.000 59.04673 ? 515 ARG   B NH1  1 
ATOM   576  N NH2  . ARG   A 1 37  ? 15.04108  4.50932   51.94282  1.000 53.33291 ? 515 ARG   B NH2  1 
ATOM   577  H H    . ARG   A 1 37  ? 18.06201  10.47554  50.59963  1.000 27.41088 ? 515 ARG   B H    1 
ATOM   578  H HA   . ARG   A 1 37  ? 18.29628  9.80082   53.06139  1.000 28.23915 ? 515 ARG   B HA   1 
ATOM   579  H HB2  . ARG   A 1 37  ? 16.35547  9.61105   51.47376  1.000 36.76402 ? 515 ARG   B HB2  1 
ATOM   580  H HB3  . ARG   A 1 37  ? 16.82210  8.09270   51.42608  1.000 36.76402 ? 515 ARG   B HB3  1 
ATOM   581  H HG2  . ARG   A 1 37  ? 16.50453  7.98485   53.75695  1.000 52.48437 ? 515 ARG   B HG2  1 
ATOM   582  H HG3  . ARG   A 1 37  ? 15.88938  9.44895   53.69842  1.000 52.48437 ? 515 ARG   B HG3  1 
ATOM   583  H HD2  . ARG   A 1 37  ? 14.17133  7.85828   53.71709  1.000 58.19505 ? 515 ARG   B HD2  1 
ATOM   584  H HD3  . ARG   A 1 37  ? 14.14613  8.65923   52.34477  1.000 58.19505 ? 515 ARG   B HD3  1 
ATOM   585  H HE   . ARG   A 1 37  ? 14.74115  6.81249   51.29594  1.000 66.39030 ? 515 ARG   B HE   1 
ATOM   586  H HH11 . ARG   A 1 37  ? 14.83488  6.12196   54.54784  1.000 70.81010 ? 515 ARG   B HH11 1 
ATOM   587  H HH12 . ARG   A 1 37  ? 15.01352  4.65254   54.38140  1.000 70.81010 ? 515 ARG   B HH12 1 
ATOM   588  H HH21 . ARG   A 1 37  ? 15.03448  4.59434   51.08705  1.000 63.95351 ? 515 ARG   B HH21 1 
ATOM   589  H HH22 . ARG   A 1 37  ? 15.13391  3.73112   52.29692  1.000 63.95351 ? 515 ARG   B HH22 1 
ATOM   590  N N    . THR   A 1 38  ? 19.63393  7.63511   51.13146  1.000 21.22503 ? 516 THR   B N    1 
ATOM   591  C CA   . THR   A 1 38  ? 20.55967  6.50956   51.11731  1.000 21.37131 ? 516 THR   B CA   1 
ATOM   592  C C    . THR   A 1 38  ? 21.88030  6.78429   50.41013  1.000 25.49455 ? 516 THR   B C    1 
ATOM   593  O O    . THR   A 1 38  ? 22.76833  5.91990   50.43744  1.000 22.69409 ? 516 THR   B O    1 
ATOM   594  C CB   . THR   A 1 38  ? 19.90259  5.27585   50.45892  1.000 22.83324 ? 516 THR   B CB   1 
ATOM   595  O OG1  . THR   A 1 38  ? 19.56635  5.52641   49.08638  1.000 21.05015 ? 516 THR   B OG1  1 
ATOM   596  C CG2  . THR   A 1 38  ? 18.66059  4.89184   51.17904  1.000 22.92713 ? 516 THR   B CG2  1 
ATOM   597  H H    . THR   A 1 38  ? 19.42290  7.93351   50.35299  1.000 25.42405 ? 516 THR   B H    1 
ATOM   598  H HA   . THR   A 1 38  ? 20.76318  6.30010   52.04230  1.000 25.59958 ? 516 THR   B HA   1 
ATOM   599  H HB   . THR   A 1 38  ? 20.54161  4.54718   50.49908  1.000 27.35390 ? 516 THR   B HB   1 
ATOM   600  H HG1  . THR   A 1 38  ? 19.01130  6.15494   49.03669  1.000 25.21420 ? 516 THR   B HG1  1 
ATOM   601  H HG21 . THR   A 1 38  ? 18.29139  4.08135   50.79473  1.000 27.46657 ? 516 THR   B HG21 1 
ATOM   602  H HG22 . THR   A 1 38  ? 18.85542  4.73541   52.11631  1.000 27.46657 ? 516 THR   B HG22 1 
ATOM   603  H HG23 . THR   A 1 38  ? 18.00320  5.60158   51.10835  1.000 27.46657 ? 516 THR   B HG23 1 
ATOM   604  N N    . CYS   A 1 39  ? 22.04446  7.95354   49.79149  1.000 22.09847 ? 517 CYS   B N    1 
ATOM   605  C CA   . CYS   A 1 39  ? 23.24934  8.31164   49.05718  1.000 21.46621 ? 517 CYS   B CA   1 
ATOM   606  C C    . CYS   A 1 39  ? 23.92201  9.56909   49.60931  1.000 28.22832 ? 517 CYS   B C    1 
ATOM   607  O O    . CYS   A 1 39  ? 24.37662  10.44531  48.85409  1.000 25.52000 ? 517 CYS   B O    1 
ATOM   608  C CB   . CYS   A 1 39  ? 22.94982  8.51888   47.57543  1.000 22.66169 ? 517 CYS   B CB   1 
ATOM   609  S SG   . CYS   A 1 39  ? 22.56684  7.03215   46.64798  1.000 24.56976 ? 517 CYS   B SG   1 
ATOM   610  H H    . CYS   A 1 39  ? 21.44898  8.57400   49.78529  1.000 26.47218 ? 517 CYS   B H    1 
ATOM   611  H HA   . CYS   A 1 39  ? 23.86696  7.57132   49.16389  1.000 25.71347 ? 517 CYS   B HA   1 
ATOM   612  H HB2  . CYS   A 1 39  ? 22.18567  9.11146   47.49902  1.000 27.14804 ? 517 CYS   B HB2  1 
ATOM   613  H HB3  . CYS   A 1 39  ? 23.72730  8.92501   47.16132  1.000 27.14804 ? 517 CYS   B HB3  1 
ATOM   614  H HG   . CYS   A 1 39  ? 22.36069  7.32791   45.50342  1.000 29.43772 ? 517 CYS   B HG   1 
ATOM   615  N N    . SER   A 1 40  ? 24.03557  9.65250   50.92596  1.000 32.10502 ? 518 SER   B N    1 
ATOM   616  C CA   . SER   A 1 40  ? 24.55120  10.86927  51.55205  1.000 33.32668 ? 518 SER   B CA   1 
ATOM   617  C C    . SER   A 1 40  ? 26.01949  11.11521  51.24154  1.000 30.62580 ? 518 SER   B C    1 
ATOM   618  O O    . SER   A 1 40  ? 26.49405  12.25218  51.40108  1.000 28.34186 ? 518 SER   B O    1 
ATOM   619  C CB   . SER   A 1 40  ? 24.35518  10.78779  53.07307  1.000 35.62073 ? 518 SER   B CB   1 
ATOM   620  O OG   . SER   A 1 40  ? 25.20666  9.79140   53.61421  1.000 38.04186 ? 518 SER   B OG   1 
ATOM   621  H H    . SER   A 1 40  ? 23.82449  9.02780   51.47804  1.000 38.48004 ? 518 SER   B H    1 
ATOM   622  H HA   . SER   A 1 40  ? 24.04904  11.62668  51.21284  1.000 39.94603 ? 518 SER   B HA   1 
ATOM   623  H HB2  . SER   A 1 40  ? 24.57355  11.64540  53.47020  1.000 42.69889 ? 518 SER   B HB2  1 
ATOM   624  H HB3  . SER   A 1 40  ? 23.43236  10.55869  53.26492  1.000 42.69889 ? 518 SER   B HB3  1 
ATOM   625  H HG   . SER   A 1 40  ? 25.10232  9.74535   54.44644  1.000 45.60425 ? 518 SER   B HG   1 
ATOM   626  N N    . SER   A 1 41  ? 26.75598  10.09794  50.80248  1.000 29.95423 ? 519 SER   B N    1 
ATOM   627  C CA   . SER   A 1 41  ? 28.17831  10.29756  50.51722  1.000 28.57121 ? 519 SER   B CA   1 
ATOM   628  C C    . SER   A 1 41  ? 28.44155  10.90096  49.13497  1.000 32.10182 ? 519 SER   B C    1 
ATOM   629  O O    . SER   A 1 41  ? 29.56171  11.34746  48.87905  1.000 33.12142 ? 519 SER   B O    1 
ATOM   630  C CB   . SER   A 1 41  ? 28.94548  8.96557   50.62054  1.000 30.58446 ? 519 SER   B CB   1 
ATOM   631  O OG   . SER   A 1 41  ? 28.65774  8.12437   49.50795  1.000 37.63925 ? 519 SER   B OG   1 
ATOM   632  H H    . SER   A 1 41  ? 26.46456  9.30071   50.66429  1.000 35.89909 ? 519 SER   B H    1 
ATOM   633  H HA   . SER   A 1 41  ? 28.52726  10.90488  51.18827  1.000 34.23947 ? 519 SER   B HA   1 
ATOM   634  H HB2  . SER   A 1 41  ? 29.89751  9.15057   50.63806  1.000 36.65537 ? 519 SER   B HB2  1 
ATOM   635  H HB3  . SER   A 1 41  ? 28.68067  8.51162   51.43584  1.000 36.65537 ? 519 SER   B HB3  1 
ATOM   636  H HG   . SER   A 1 41  ? 27.83562  7.95396   49.48165  1.000 45.12112 ? 519 SER   B HG   1 
ATOM   637  N N    . TYR   A 1 42  ? 27.45514  10.92094  48.24040  1.000 22.86319 ? 520 TYR   B N    1 
ATOM   638  C CA   . TYR   A 1 42  ? 27.59093  11.51716  46.92713  1.000 21.47752 ? 520 TYR   B CA   1 
ATOM   639  C C    . TYR   A 1 42  ? 27.07887  12.94974  46.97457  1.000 19.27588 ? 520 TYR   B C    1 
ATOM   640  O O    . TYR   A 1 42  ? 26.47225  13.38709  47.96207  1.000 23.29314 ? 520 TYR   B O    1 
ATOM   641  C CB   . TYR   A 1 42  ? 26.80709  10.72502  45.87876  1.000 21.44262 ? 520 TYR   B CB   1 
ATOM   642  C CG   . TYR   A 1 42  ? 27.43347  9.36479   45.54860  1.000 21.10815 ? 520 TYR   B CG   1 
ATOM   643  C CD1  . TYR   A 1 42  ? 28.46780  9.27690   44.64541  1.000 21.65923 ? 520 TYR   B CD1  1 
ATOM   644  C CD2  . TYR   A 1 42  ? 26.99219  8.20869   46.15793  1.000 23.22226 ? 520 TYR   B CD2  1 
ATOM   645  C CE1  . TYR   A 1 42  ? 29.04987  8.05981   44.32843  1.000 22.52467 ? 520 TYR   B CE1  1 
ATOM   646  C CE2  . TYR   A 1 42  ? 27.56137  7.00387   45.85756  1.000 21.98794 ? 520 TYR   B CE2  1 
ATOM   647  C CZ   . TYR   A 1 42  ? 28.57823  6.92873   44.94618  1.000 22.60357 ? 520 TYR   B CZ   1 
ATOM   648  O OH   . TYR   A 1 42  ? 29.16337  5.71935   44.63388  1.000 25.06259 ? 520 TYR   B OH   1 
ATOM   649  H H    . TYR   A 1 42  ? 26.67650  10.58379  48.38058  1.000 27.38984 ? 520 TYR   B H    1 
ATOM   650  H HA   . TYR   A 1 42  ? 28.52520  11.50837  46.66642  1.000 25.72704 ? 520 TYR   B HA   1 
ATOM   651  H HB2  . TYR   A 1 42  ? 25.91012  10.56644  46.21221  1.000 25.68516 ? 520 TYR   B HB2  1 
ATOM   652  H HB3  . TYR   A 1 42  ? 26.76967  11.24217  45.05897  1.000 25.68516 ? 520 TYR   B HB3  1 
ATOM   653  H HD1  . TYR   A 1 42  ? 28.78329  10.05144  44.23864  1.000 25.94509 ? 520 TYR   B HD1  1 
ATOM   654  H HD2  . TYR   A 1 42  ? 26.30099  8.24988   46.77877  1.000 27.82073 ? 520 TYR   B HD2  1 
ATOM   655  H HE1  . TYR   A 1 42  ? 29.74398  8.01069   43.71141  1.000 26.98362 ? 520 TYR   B HE1  1 
ATOM   656  H HE2  . TYR   A 1 42  ? 27.25591  6.23091   46.27486  1.000 26.33954 ? 520 TYR   B HE2  1 
ATOM   657  H HH   . TYR   A 1 42  ? 29.77501  5.83336   44.06952  1.000 30.02913 ? 520 TYR   B HH   1 
ATOM   658  N N    . ALA   A 1 43  ? 27.33548  13.68215  45.89164  1.000 16.33767 ? 521 ALA   B N    1 
ATOM   659  C CA   . ALA   A 1 43  ? 26.88891  15.06113  45.77637  1.000 17.40280 ? 521 ALA   B CA   1 
ATOM   660  C C    . ALA   A 1 43  ? 26.22228  15.25542  44.42288  1.000 15.10237 ? 521 ALA   B C    1 
ATOM   661  O O    . ALA   A 1 43  ? 26.77026  14.86717  43.39482  1.000 14.79540 ? 521 ALA   B O    1 
ATOM   662  C CB   . ALA   A 1 43  ? 28.06348  16.03962  45.94066  1.000 21.91347 ? 521 ALA   B CB   1 
ATOM   663  H H    . ALA   A 1 43  ? 27.77050  13.39608  45.20715  1.000 19.55921 ? 521 ALA   B H    1 
ATOM   664  H HA   . ALA   A 1 43  ? 26.23557  15.25192  46.46750  1.000 20.83738 ? 521 ALA   B HA   1 
ATOM   665  H HB1  . ALA   A 1 43  ? 27.73158  16.94760  45.86124  1.000 26.25018 ? 521 ALA   B HB1  1 
ATOM   666  H HB2  . ALA   A 1 43  ? 28.46351  15.90892  46.81462  1.000 26.25018 ? 521 ALA   B HB2  1 
ATOM   667  H HB3  . ALA   A 1 43  ? 28.71910  15.86526  45.24737  1.000 26.25018 ? 521 ALA   B HB3  1 
ATOM   668  N N    . ILE   A 1 44  ? 25.08974  15.92734  44.42072  1.000 17.04855 ? 522 ILE   B N    1 
ATOM   669  C CA   . ILE   A 1 44  ? 24.32168  16.14216  43.19010  1.000 15.42317 ? 522 ILE   B CA   1 
ATOM   670  C C    . ILE   A 1 44  ? 24.88135  17.33694  42.42516  1.000 15.76553 ? 522 ILE   B C    1 
ATOM   671  O O    . ILE   A 1 44  ? 25.06670  18.43049  42.98191  1.000 16.38563 ? 522 ILE   B O    1 
ATOM   672  C CB   . ILE   A 1 44  ? 22.82030  16.33630  43.51395  1.000 13.88309 ? 522 ILE   B CB   1 
ATOM   673  C CG1  . ILE   A 1 44  ? 22.25464  15.02007  44.03707  1.000 15.02187 ? 522 ILE   B CG1  1 
ATOM   674  C CG2  . ILE   A 1 44  ? 22.09366  16.86607  42.32114  1.000 15.22390 ? 522 ILE   B CG2  1 
ATOM   675  C CD1  . ILE   A 1 44  ? 20.79019  15.11591  44.50562  1.000 18.09201 ? 522 ILE   B CD1  1 
ATOM   676  H H    . ILE   A 1 44  ? 24.73247  16.27660  45.12070  1.000 20.41227 ? 522 ILE   B H    1 
ATOM   677  H HA   . ILE   A 1 44  ? 24.42011  15.36098  42.62356  1.000 18.46182 ? 522 ILE   B HA   1 
ATOM   678  H HB   . ILE   A 1 44  ? 22.70539  17.00031  44.21165  1.000 16.61372 ? 522 ILE   B HB   1 
ATOM   679  H HG12 . ILE   A 1 44  ? 22.29592  14.35929  43.32815  1.000 17.98026 ? 522 ILE   B HG12 1 
ATOM   680  H HG13 . ILE   A 1 44  ? 22.78879  14.72961  44.79285  1.000 17.98026 ? 522 ILE   B HG13 1 
ATOM   681  H HG21 . ILE   A 1 44  ? 21.14027  16.74504  42.45268  1.000 18.22270 ? 522 ILE   B HG21 1 
ATOM   682  H HG22 . ILE   A 1 44  ? 22.29663  17.80929  42.22093  1.000 18.22270 ? 522 ILE   B HG22 1 
ATOM   683  H HG23 . ILE   A 1 44  ? 22.38322  16.37989  41.53331  1.000 18.22270 ? 522 ILE   B HG23 1 
ATOM   684  H HD11 . ILE   A 1 44  ? 20.57690  14.33322  45.03742  1.000 21.66443 ? 522 ILE   B HD11 1 
ATOM   685  H HD12 . ILE   A 1 44  ? 20.68134  15.91834  45.03963  1.000 21.66443 ? 522 ILE   B HD12 1 
ATOM   686  H HD13 . ILE   A 1 44  ? 20.21172  15.15511  43.72797  1.000 21.66443 ? 522 ILE   B HD13 1 
ATOM   687  N N    . GLU   A 1 45  ? 25.16982  17.12651  41.15125  1.000 12.61960 ? 523 GLU   B N    1 
ATOM   688  C CA   . GLU   A 1 45  ? 25.52370  18.22865  40.27101  1.000 13.72334 ? 523 GLU   B CA   1 
ATOM   689  C C    . GLU   A 1 45  ? 24.28860  18.98027  39.80266  1.000 13.62470 ? 523 GLU   B C    1 
ATOM   690  O O    . GLU   A 1 45  ? 24.22663  20.22055  39.89979  1.000 14.09102 ? 523 GLU   B O    1 
ATOM   691  C CB   . GLU   A 1 45  ? 26.28548  17.73742  39.05491  1.000 13.46578 ? 523 GLU   B CB   1 
ATOM   692  C CG   . GLU   A 1 45  ? 26.57633  18.77752  38.00931  1.000 13.61501 ? 523 GLU   B CG   1 
ATOM   693  C CD   . GLU   A 1 45  ? 27.39470  18.23186  36.83769  1.000 16.50545 ? 523 GLU   B CD   1 
ATOM   694  O OE1  . GLU   A 1 45  ? 28.50415  17.74122  37.06345  1.000 14.67942 ? 523 GLU   B OE1  1 
ATOM   695  O OE2  . GLU   A 1 45  ? 26.90589  18.30121  35.68892  1.000 18.23882 ? 523 GLU   B OE2  1 
ATOM   696  H H    . GLU   A 1 45  ? 25.16839  16.35554  40.77018  1.000 15.09753 ? 523 GLU   B H    1 
ATOM   697  H HA   . GLU   A 1 45  ? 26.09905  18.82670  40.77322  1.000 16.42202 ? 523 GLU   B HA   1 
ATOM   698  H HB2  . GLU   A 1 45  ? 27.13723  17.38093  39.35212  1.000 16.11296 ? 523 GLU   B HB2  1 
ATOM   699  H HB3  . GLU   A 1 45  ? 25.76363  17.03893  38.62983  1.000 16.11296 ? 523 GLU   B HB3  1 
ATOM   700  H HG2  . GLU   A 1 45  ? 25.73748  19.11417  37.65731  1.000 16.29202 ? 523 GLU   B HG2  1 
ATOM   701  H HG3  . GLU   A 1 45  ? 27.07987  19.50052  38.41503  1.000 16.29202 ? 523 GLU   B HG3  1 
ATOM   702  N N    . LYS   A 1 46  ? 23.30354  18.25387  39.28003  1.000 13.55326 ? 524 LYS   B N    1 
ATOM   703  C CA   . LYS   A 1 46  ? 22.08099  18.89124  38.80293  1.000 12.78494 ? 524 LYS   B CA   1 
ATOM   704  C C    . LYS   A 1 46  ? 20.97432  17.84439  38.72908  1.000 13.92707 ? 524 LYS   B C    1 
ATOM   705  O O    . LYS   A 1 46  ? 21.22823  16.63582  38.71012  1.000 12.60089 ? 524 LYS   B O    1 
ATOM   706  C CB   . LYS   A 1 46  ? 22.25281  19.54070  37.43086  1.000 14.79485 ? 524 LYS   B CB   1 
ATOM   707  C CG   . LYS   A 1 46  ? 22.66557  18.59548  36.30374  1.000 12.63794 ? 524 LYS   B CG   1 
ATOM   708  C CD   . LYS   A 1 46  ? 22.82990  19.32028  34.99808  1.000 15.22639 ? 524 LYS   B CD   1 
ATOM   709  C CE   . LYS   A 1 46  ? 23.31427  18.37640  33.87938  1.000 21.19021 ? 524 LYS   B CE   1 
ATOM   710  N NZ   . LYS   A 1 46  ? 23.45190  19.10039  32.60592  1.000 30.70065 ? 524 LYS   B NZ   1 
ATOM   711  H H    . LYS   A 1 46  ? 23.31941  17.39855  39.19181  1.000 16.21793 ? 524 LYS   B H    1 
ATOM   712  H HA   . LYS   A 1 46  ? 21.83447  19.57955  39.44039  1.000 15.29594 ? 524 LYS   B HA   1 
ATOM   713  H HB2  . LYS   A 1 46  ? 21.40781  19.94287  37.17564  1.000 17.70783 ? 524 LYS   B HB2  1 
ATOM   714  H HB3  . LYS   A 1 46  ? 22.93785  20.22392  37.50027  1.000 17.70783 ? 524 LYS   B HB3  1 
ATOM   715  H HG2  . LYS   A 1 46  ? 23.51268  18.17993  36.52874  1.000 15.11954 ? 524 LYS   B HG2  1 
ATOM   716  H HG3  . LYS   A 1 46  ? 21.98270  17.91609  36.18971  1.000 15.11954 ? 524 LYS   B HG3  1 
ATOM   717  H HD2  . LYS   A 1 46  ? 21.97668  19.69620  34.73051  1.000 18.22568 ? 524 LYS   B HD2  1 
ATOM   718  H HD3  . LYS   A 1 46  ? 23.48533  20.02741  35.10426  1.000 18.22568 ? 524 LYS   B HD3  1 
ATOM   719  H HE2  . LYS   A 1 46  ? 24.17899  18.00786  34.11883  1.000 25.38226 ? 524 LYS   B HE2  1 
ATOM   720  H HE3  . LYS   A 1 46  ? 22.67062  17.66085  33.75853  1.000 25.38226 ? 524 LYS   B HE3  1 
ATOM   721  H HZ1  . LYS   A 1 46  ? 23.73341  18.54576  31.96933  1.000 36.79480 ? 524 LYS   B HZ1  1 
ATOM   722  H HZ2  . LYS   A 1 46  ? 22.66686  19.44295  32.36413  1.000 36.79480 ? 524 LYS   B HZ2  1 
ATOM   723  H HZ3  . LYS   A 1 46  ? 24.04087  19.76181  32.69391  1.000 36.79480 ? 524 LYS   B HZ3  1 
ATOM   724  N N    . ILE   A 1 47  ? 19.74223  18.33636  38.68649  1.000 13.15362 ? 525 ILE   B N    1 
ATOM   725  C CA   . ILE   A 1 47  ? 18.53837  17.49706  38.53975  1.000 13.45012 ? 525 ILE   B CA   1 
ATOM   726  C C    . ILE   A 1 47  ? 17.71188  18.10453  37.41980  1.000 14.19063 ? 525 ILE   B C    1 
ATOM   727  O O    . ILE   A 1 47  ? 17.39302  19.30153  37.46607  1.000 13.78318 ? 525 ILE   B O    1 
ATOM   728  C CB   . ILE   A 1 47  ? 17.70663  17.44261  39.82097  1.000 13.52662 ? 525 ILE   B CB   1 
ATOM   729  C CG1  . ILE   A 1 47  ? 18.54081  16.97772  41.01220  1.000 14.34957 ? 525 ILE   B CG1  1 
ATOM   730  C CG2  . ILE   A 1 47  ? 16.48228  16.54213  39.62798  1.000 15.00090 ? 525 ILE   B CG2  1 
ATOM   731  C CD1  . ILE   A 1 47  ? 17.78745  17.03376  42.32310  1.000 14.87608 ? 525 ILE   B CD1  1 
ATOM   732  H H    . ILE   A 1 47  ? 19.56406  19.17590  38.74153  1.000 15.73836 ? 525 ILE   B H    1 
ATOM   733  H HA   . ILE   A 1 47  ? 18.80009  16.59289  38.30549  1.000 16.09416 ? 525 ILE   B HA   1 
ATOM   734  H HB   . ILE   A 1 47  ? 17.40282  18.34371  40.01232  1.000 16.18596 ? 525 ILE   B HB   1 
ATOM   735  H HG12 . ILE   A 1 47  ? 18.81529  16.05918  40.86440  1.000 17.17349 ? 525 ILE   B HG12 1 
ATOM   736  H HG13 . ILE   A 1 47  ? 19.32109  17.54849  41.09141  1.000 17.17349 ? 525 ILE   B HG13 1 
ATOM   737  H HG21 . ILE   A 1 47  ? 15.97325  16.52005  40.45339  1.000 17.95509 ? 525 ILE   B HG21 1 
ATOM   738  H HG22 . ILE   A 1 47  ? 15.93567  16.90155  38.91178  1.000 17.95509 ? 525 ILE   B HG22 1 
ATOM   739  H HG23 . ILE   A 1 47  ? 16.78078  15.64795  39.39942  1.000 17.95509 ? 525 ILE   B HG23 1 
ATOM   740  H HD11 . ILE   A 1 47  ? 18.41691  16.92984  43.05377  1.000 17.80531 ? 525 ILE   B HD11 1 
ATOM   741  H HD12 . ILE   A 1 47  ? 17.33827  17.89067  42.39282  1.000 17.80531 ? 525 ILE   B HD12 1 
ATOM   742  H HD13 . ILE   A 1 47  ? 17.13543  16.31588  42.34357  1.000 17.80531 ? 525 ILE   B HD13 1 
ATOM   743  N N    . GLU   A 1 48  ? 17.40188  17.30211  36.40590  1.000 13.24239 ? 526 GLU   B N    1 
ATOM   744  C CA   . GLU   A 1 48  ? 16.64053  17.74830  35.25752  1.000 13.68755 ? 526 GLU   B CA   1 
ATOM   745  C C    . GLU   A 1 48  ? 15.30046  17.06182  35.20376  1.000 14.34635 ? 526 GLU   B C    1 
ATOM   746  O O    . GLU   A 1 48  ? 15.24428  15.84780  35.33313  1.000 14.10258 ? 526 GLU   B O    1 
ATOM   747  C CB   . GLU   A 1 48  ? 17.38991  17.45982  33.95672  1.000 14.88747 ? 526 GLU   B CB   1 
ATOM   748  C CG   . GLU   A 1 48  ? 18.70324  18.27293  33.81333  1.000 16.65201 ? 526 GLU   B CG   1 
ATOM   749  C CD   . GLU   A 1 48  ? 19.50755  17.76855  32.66014  1.000 18.80997 ? 526 GLU   B CD   1 
ATOM   750  O OE1  . GLU   A 1 48  ? 20.18969  16.72884  32.81472  1.000 16.96552 ? 526 GLU   B OE1  1 
ATOM   751  O OE2  . GLU   A 1 48  ? 19.46007  18.39599  31.59434  1.000 21.40513 ? 526 GLU   B OE2  1 
ATOM   752  H H    . GLU   A 1 48  ? 17.63029  16.47401  36.36501  1.000 15.84488 ? 526 GLU   B H    1 
ATOM   753  H HA   . GLU   A 1 48  ? 16.49406  18.70288  35.34823  1.000 16.37907 ? 526 GLU   B HA   1 
ATOM   754  H HB2  . GLU   A 1 48  ? 17.61793  16.51743  33.92836  1.000 17.81898 ? 526 GLU   B HB2  1 
ATOM   755  H HB3  . GLU   A 1 48  ? 16.81633  17.68506  33.20762  1.000 17.81898 ? 526 GLU   B HB3  1 
ATOM   756  H HG2  . GLU   A 1 48  ? 18.49169  19.20678  33.65814  1.000 19.93642 ? 526 GLU   B HG2  1 
ATOM   757  H HG3  . GLU   A 1 48  ? 19.23119  18.18232  34.62200  1.000 19.93642 ? 526 GLU   B HG3  1 
ATOM   758  N N    . ARG   A 1 49  ? 14.23540  17.84568  34.98757  1.000 14.05088 ? 527 ARG   B N    1 
ATOM   759  C CA   . ARG   A 1 49  ? 12.92015  17.28834  34.71248  1.000 13.48791 ? 527 ARG   B CA   1 
ATOM   760  C C    . ARG   A 1 49  ? 12.85496  16.87953  33.25038  1.000 14.40428 ? 527 ARG   B C    1 
ATOM   761  O O    . ARG   A 1 49  ? 13.17158  17.66000  32.34745  1.000 15.70796 ? 527 ARG   B O    1 
ATOM   762  C CB   . ARG   A 1 49  ? 11.82623  18.30022  35.03009  1.000 17.32286 ? 527 ARG   B CB   1 
ATOM   763  C CG   . ARG   A 1 49  ? 10.40593  17.69716  34.96638  1.000 15.63174 ? 527 ARG   B CG   1 
ATOM   764  C CD   . ARG   A 1 49  ? 9.39914   18.81080  34.73290  1.000 17.20979 ? 527 ARG   B CD   1 
ATOM   765  N NE   . ARG   A 1 49  ? 9.41566   19.79886  35.79420  1.000 19.71889 ? 527 ARG   B NE   1 
ATOM   766  C CZ   . ARG   A 1 49  ? 9.34171   21.11121  35.61432  1.000 22.17078 ? 527 ARG   B CZ   1 
ATOM   767  N NH1  . ARG   A 1 49  ? 9.26659   21.65040  34.40087  1.000 25.53048 ? 527 ARG   B NH1  1 
ATOM   768  N NH2  . ARG   A 1 49  ? 9.36677   21.90882  36.67515  1.000 23.12749 ? 527 ARG   B NH2  1 
ATOM   769  H H    . ARG   A 1 49  ? 14.25609  18.70538  34.99641  1.000 16.81507 ? 527 ARG   B H    1 
ATOM   770  H HA   . ARG   A 1 49  ? 12.76767  16.50928  35.26990  1.000 16.13951 ? 527 ARG   B HA   1 
ATOM   771  H HB2  . ARG   A 1 49  ? 11.96561  18.64272  35.92684  1.000 20.74144 ? 527 ARG   B HB2  1 
ATOM   772  H HB3  . ARG   A 1 49  ? 11.87231  19.02512  34.38721  1.000 20.74144 ? 527 ARG   B HB3  1 
ATOM   773  H HG2  . ARG   A 1 49  ? 10.34915  17.06352  34.23414  1.000 18.71211 ? 527 ARG   B HG2  1 
ATOM   774  H HG3  . ARG   A 1 49  ? 10.19724  17.25538  35.80434  1.000 18.71211 ? 527 ARG   B HG3  1 
ATOM   775  H HD2  . ARG   A 1 49  ? 9.60933   19.25994  33.89924  1.000 20.60577 ? 527 ARG   B HD2  1 
ATOM   776  H HD3  . ARG   A 1 49  ? 8.50810   18.42997  34.68909  1.000 20.60577 ? 527 ARG   B HD3  1 
ATOM   777  H HE   . ARG   A 1 49  ? 9.47822   19.51200  36.60253  1.000 23.61668 ? 527 ARG   B HE   1 
ATOM   778  H HH11 . ARG   A 1 49  ? 9.26504   21.14496  33.70508  1.000 30.59059 ? 527 ARG   B HH11 1 
ATOM   779  H HH12 . ARG   A 1 49  ? 9.21957   22.50450  34.31201  1.000 30.59059 ? 527 ARG   B HH12 1 
ATOM   780  H HH21 . ARG   A 1 49  ? 9.43015   21.57290  37.46429  1.000 27.70700 ? 527 ARG   B HH21 1 
ATOM   781  H HH22 . ARG   A 1 49  ? 9.31962   22.76146  36.57327  1.000 27.70700 ? 527 ARG   B HH22 1 
ATOM   782  N N    . ILE   A 1 50  ? 12.44560  15.63668  33.01423  1.000 14.50716 ? 528 ILE   B N    1 
ATOM   783  C CA   . ILE   A 1 50  ? 12.32505  15.10071  31.66696  1.000 15.00680 ? 528 ILE   B CA   1 
ATOM   784  C C    . ILE   A 1 50  ? 10.89731  15.31008  31.18597  1.000 13.02486 ? 528 ILE   B C    1 
ATOM   785  O O    . ILE   A 1 50  ? 9.96057   14.77686  31.76204  1.000 13.59174 ? 528 ILE   B O    1 
ATOM   786  C CB   . ILE   A 1 50  ? 12.70264  13.60446  31.63835  1.000 15.86540 ? 528 ILE   B CB   1 
ATOM   787  C CG1  . ILE   A 1 50  ? 14.14033  13.42503  32.11473  1.000 16.41132 ? 528 ILE   B CG1  1 
ATOM   788  C CG2  . ILE   A 1 50  ? 12.47575  13.05500  30.24460  1.000 15.31415 ? 528 ILE   B CG2  1 
ATOM   789  C CD1  . ILE   A 1 50  ? 14.48577  12.02746  32.52925  1.000 16.35729 ? 528 ILE   B CD1  1 
ATOM   790  H H    . ILE   A 1 50  ? 12.22870  15.07672  33.62986  1.000 17.36261 ? 528 ILE   B H    1 
ATOM   791  H HA   . ILE   A 1 50  ? 12.91879  15.58582  31.07279  1.000 17.96218 ? 528 ILE   B HA   1 
ATOM   792  H HB   . ILE   A 1 50  ? 12.13716  13.10320  32.24652  1.000 18.99250 ? 528 ILE   B HB   1 
ATOM   793  H HG12 . ILE   A 1 50  ? 14.73865  13.67302  31.39264  1.000 19.64760 ? 528 ILE   B HG12 1 
ATOM   794  H HG13 . ILE   A 1 50  ? 14.28688  14.00255  32.88017  1.000 19.64760 ? 528 ILE   B HG13 1 
ATOM   795  H HG21 . ILE   A 1 50  ? 12.92011  12.19623  30.16748  1.000 18.33099 ? 528 ILE   B HG21 1 
ATOM   796  H HG22 . ILE   A 1 50  ? 11.52276  12.94864  30.09834  1.000 18.33099 ? 528 ILE   B HG22 1 
ATOM   797  H HG23 . ILE   A 1 50  ? 12.84252  13.67659  29.59651  1.000 18.33099 ? 528 ILE   B HG23 1 
ATOM   798  H HD11 . ILE   A 1 50  ? 15.39593  12.01330  32.86437  1.000 19.58276 ? 528 ILE   B HD11 1 
ATOM   799  H HD12 . ILE   A 1 50  ? 13.87256  11.74381  33.22525  1.000 19.58276 ? 528 ILE   B HD12 1 
ATOM   800  H HD13 . ILE   A 1 50  ? 14.40727  11.44146  31.76026  1.000 19.58276 ? 528 ILE   B HD13 1 
ATOM   801  N N    . GLN   A 1 51  ? 10.73262  16.12021  30.15020  1.000 15.45686 ? 529 GLN   B N    1 
ATOM   802  C CA   . GLN   A 1 51  ? 9.45871   16.41849  29.53284  1.000 17.70267 ? 529 GLN   B CA   1 
ATOM   803  C C    . GLN   A 1 51  ? 9.46681   15.75182  28.16449  1.000 17.04333 ? 529 GLN   B C    1 
ATOM   804  O O    . GLN   A 1 51  ? 9.96387   16.30469  27.19108  1.000 18.08245 ? 529 GLN   B O    1 
ATOM   805  C CB   . GLN   A 1 51  ? 9.21822   17.95527  29.43501  1.000 16.77584 ? 529 GLN   B CB   1 
ATOM   806  C CG   . GLN   A 1 51  ? 9.24913   18.63060  30.76863  1.000 16.20362 ? 529 GLN   B CG   1 
ATOM   807  C CD   . GLN   A 1 51  ? 8.84484   20.09929  30.72501  1.000 18.71334 ? 529 GLN   B CD   1 
ATOM   808  O OE1  . GLN   A 1 51  ? 8.80058   20.74753  31.75071  1.000 16.74523 ? 529 GLN   B OE1  1 
ATOM   809  N NE2  . GLN   A 1 51  ? 8.60668   20.61244  29.53476  1.000 18.50503 ? 529 GLN   B NE2  1 
ATOM   810  H H    . GLN   A 1 51  ? 11.38501  16.53058  29.76866  1.000 18.50224 ? 529 GLN   B H    1 
ATOM   811  H HA   . GLN   A 1 51  ? 8.73915   16.04318  30.06415  1.000 21.19721 ? 529 GLN   B HA   1 
ATOM   812  H HB2  . GLN   A 1 51  ? 9.91165   18.34890  28.88264  1.000 20.08502 ? 529 GLN   B HB2  1 
ATOM   813  H HB3  . GLN   A 1 51  ? 8.34763   18.11403  29.03782  1.000 20.08502 ? 529 GLN   B HB3  1 
ATOM   814  H HG2  . GLN   A 1 51  ? 8.63541   18.17295  31.36429  1.000 19.39836 ? 529 GLN   B HG2  1 
ATOM   815  H HG3  . GLN   A 1 51  ? 10.15142  18.58305  31.12149  1.000 19.39836 ? 529 GLN   B HG3  1 
ATOM   816  H HE21 . GLN   A 1 51  ? 8.68246   20.12229  28.83219  1.000 22.16005 ? 529 GLN   B HE21 1 
ATOM   817  H HE22 . GLN   A 1 51  ? 8.37548   21.43745  29.46062  1.000 22.16005 ? 529 GLN   B HE22 1 
ATOM   818  N N    . ASN   A 1 52  ? 8.93598   14.52624  28.10369  1.000 17.61244 ? 530 ASN   B N    1 
ATOM   819  C CA   . ASN   A 1 52  ? 8.86323   13.75578  26.85792  1.000 16.36137 ? 530 ASN   B CA   1 
ATOM   820  C C    . ASN   A 1 52  ? 7.39462   13.47938  26.57631  1.000 15.99959 ? 530 ASN   B C    1 
ATOM   821  O O    . ASN   A 1 52  ? 6.78697   12.63182  27.22795  1.000 14.31843 ? 530 ASN   B O    1 
ATOM   822  C CB   . ASN   A 1 52  ? 9.65281   12.46079  26.96848  1.000 16.45310 ? 530 ASN   B CB   1 
ATOM   823  C CG   . ASN   A 1 52  ? 9.67434   11.69905  25.66215  1.000 15.07288 ? 530 ASN   B CG   1 
ATOM   824  O OD1  . ASN   A 1 52  ? 8.62765   11.63120  24.94019  1.000 15.74714 ? 530 ASN   B OD1  1 
ATOM   825  N ND2  . ASN   A 1 52  ? 10.84154  11.14761  25.31778  1.000 16.53739 ? 530 ASN   B ND2  1 
ATOM   826  H H    . ASN   A 1 52  ? 8.60625   14.11388  28.78255  1.000 21.08895 ? 530 ASN   B H    1 
ATOM   827  H HA   . ASN   A 1 52  ? 9.23415   14.27328  26.12614  1.000 19.58766 ? 530 ASN   B HA   1 
ATOM   828  H HB2  . ASN   A 1 52  ? 10.56825  12.66513  27.21569  1.000 19.69773 ? 530 ASN   B HB2  1 
ATOM   829  H HB3  . ASN   A 1 52  ? 9.24543   11.89506  27.64294  1.000 19.69773 ? 530 ASN   B HB3  1 
ATOM   830  H HD21 . ASN   A 1 52  ? 10.90754  10.70359  24.58424  1.000 19.79889 ? 530 ASN   B HD21 1 
ATOM   831  H HD22 . ASN   A 1 52  ? 11.52685  11.23667  25.82966  1.000 19.79889 ? 530 ASN   B HD22 1 
ATOM   832  N N    . ALA   A 1 53  ? 6.82493   14.19661  25.60638  1.000 15.44020 ? 531 ALA   B N    1 
ATOM   833  C CA   . ALA   A 1 53  ? 5.37980   14.19881  25.44165  1.000 16.61059 ? 531 ALA   B CA   1 
ATOM   834  C C    . ALA   A 1 53  ? 4.86722   12.81955  25.05458  1.000 14.63872 ? 531 ALA   B C    1 
ATOM   835  O O    . ALA   A 1 53  ? 3.88287   12.33501  25.62124  1.000 15.55194 ? 531 ALA   B O    1 
ATOM   836  C CB   . ALA   A 1 53  ? 4.98130   15.21681  24.38727  1.000 17.58306 ? 531 ALA   B CB   1 
ATOM   837  H H    . ALA   A 1 53  ? 7.25060   14.68325  25.03929  1.000 18.48225 ? 531 ALA   B H    1 
ATOM   838  H HA   . ALA   A 1 53  ? 4.97329   14.45039  26.28566  1.000 19.88672 ? 531 ALA   B HA   1 
ATOM   839  H HB1  . ALA   A 1 53  ? 4.01625   15.20914  24.28970  1.000 21.05369 ? 531 ALA   B HB1  1 
ATOM   840  H HB2  . ALA   A 1 53  ? 5.27830   16.09616  24.66913  1.000 21.05369 ? 531 ALA   B HB2  1 
ATOM   841  H HB3  . ALA   A 1 53  ? 5.40079   14.98012  23.54530  1.000 21.05369 ? 531 ALA   B HB3  1 
ATOM   842  N N    . PHE   A 1 54  ? 5.51520   12.18170  24.07544  1.000 14.61320 ? 532 PHE   B N    1 
ATOM   843  C CA   . PHE   A 1 54  ? 5.03196   10.89561  23.59854  1.000 16.75936 ? 532 PHE   B CA   1 
ATOM   844  C C    . PHE   A 1 54  ? 5.20081   9.81737   24.66966  1.000 15.78272 ? 532 PHE   B C    1 
ATOM   845  O O    . PHE   A 1 54  ? 4.31902   8.97352   24.84875  1.000 14.47076 ? 532 PHE   B O    1 
ATOM   846  C CB   . PHE   A 1 54  ? 5.75917   10.47305  22.32223  1.000 19.16049 ? 532 PHE   B CB   1 
ATOM   847  C CG   . PHE   A 1 54  ? 5.35206   11.22881  21.09420  1.000 17.74856 ? 532 PHE   B CG   1 
ATOM   848  C CD1  . PHE   A 1 54  ? 4.30560   12.12041  21.10649  1.000 19.79036 ? 532 PHE   B CD1  1 
ATOM   849  C CD2  . PHE   A 1 54  ? 6.01253   10.99202  19.88354  1.000 22.81954 ? 532 PHE   B CD2  1 
ATOM   850  C CE1  . PHE   A 1 54  ? 3.93691   12.79133  19.96862  1.000 24.24337 ? 532 PHE   B CE1  1 
ATOM   851  C CE2  . PHE   A 1 54  ? 5.64768   11.67922  18.74465  1.000 22.74350 ? 532 PHE   B CE2  1 
ATOM   852  C CZ   . PHE   A 1 54  ? 4.61509   12.56502  18.78656  1.000 22.37865 ? 532 PHE   B CZ   1 
ATOM   853  H H    . PHE   A 1 54  ? 6.22289   12.47034  23.68115  1.000 17.48986 ? 532 PHE   B H    1 
ATOM   854  H HA   . PHE   A 1 54  ? 4.09029   10.98965  23.38568  1.000 20.06525 ? 532 PHE   B HA   1 
ATOM   855  H HB2  . PHE   A 1 54  ? 6.71086   10.61140  22.44890  1.000 22.94660 ? 532 PHE   B HB2  1 
ATOM   856  H HB3  . PHE   A 1 54  ? 5.57906   9.53368   22.16084  1.000 22.94660 ? 532 PHE   B HB3  1 
ATOM   857  H HD1  . PHE   A 1 54  ? 3.84098   12.27075  21.89796  1.000 23.70244 ? 532 PHE   B HD1  1 
ATOM   858  H HD2  . PHE   A 1 54  ? 6.70112   10.36801  19.84661  1.000 27.33747 ? 532 PHE   B HD2  1 
ATOM   859  H HE1  . PHE   A 1 54  ? 3.23188   13.39733  19.99273  1.000 29.04605 ? 532 PHE   B HE1  1 
ATOM   860  H HE2  . PHE   A 1 54  ? 6.10697   11.53741  17.94850  1.000 27.24622 ? 532 PHE   B HE2  1 
ATOM   861  H HZ   . PHE   A 1 54  ? 4.36476   13.02035  18.01526  1.000 26.80839 ? 532 PHE   B HZ   1 
ATOM   862  N N    . LEU   A 1 55  ? 6.34697   9.78135   25.37107  1.000 15.71818 ? 533 LEU   B N    1 
ATOM   863  C CA   . LEU   A 1 55  ? 6.48810   8.77339   26.42391  1.000 14.71556 ? 533 LEU   B CA   1 
ATOM   864  C C    . LEU   A 1 55  ? 5.44660   8.99046   27.51939  1.000 15.59350 ? 533 LEU   B C    1 
ATOM   865  O O    . LEU   A 1 55  ? 4.95332   8.03797   28.12237  1.000 13.99696 ? 533 LEU   B O    1 
ATOM   866  C CB   . LEU   A 1 55  ? 7.88852   8.79467   27.03049  1.000 17.54590 ? 533 LEU   B CB   1 
ATOM   867  C CG   . LEU   A 1 55  ? 9.04306   8.27064   26.21549  1.000 19.14148 ? 533 LEU   B CG   1 
ATOM   868  C CD1  . LEU   A 1 55  ? 10.32768  8.39352   27.06244  1.000 19.48542 ? 533 LEU   B CD1  1 
ATOM   869  C CD2  . LEU   A 1 55  ? 8.78892   6.85895   25.76692  1.000 19.25759 ? 533 LEU   B CD2  1 
ATOM   870  H H    . LEU   A 1 55  ? 7.02087   10.30392  25.25981  1.000 18.81584 ? 533 LEU   B H    1 
ATOM   871  H HA   . LEU   A 1 55  ? 6.35799   7.89978   26.02293  1.000 17.61268 ? 533 LEU   B HA   1 
ATOM   872  H HB2  . LEU   A 1 55  ? 8.09925   9.71717   27.24378  1.000 21.00910 ? 533 LEU   B HB2  1 
ATOM   873  H HB3  . LEU   A 1 55  ? 7.86215   8.26419   27.84215  1.000 21.00910 ? 533 LEU   B HB3  1 
ATOM   874  H HG   . LEU   A 1 55  ? 9.15588   8.78908   25.40346  1.000 22.92379 ? 533 LEU   B HG   1 
ATOM   875  H HD11 . LEU   A 1 55  ? 11.07981  8.06622   26.54467  1.000 23.33652 ? 533 LEU   B HD11 1 
ATOM   876  H HD12 . LEU   A 1 55  ? 10.46567  9.32544   27.29348  1.000 23.33652 ? 533 LEU   B HD12 1 
ATOM   877  H HD13 . LEU   A 1 55  ? 10.22601  7.86432   27.86898  1.000 23.33652 ? 533 LEU   B HD13 1 
ATOM   878  H HD21 . LEU   A 1 55  ? 9.60813   6.49211   25.39920  1.000 23.06312 ? 533 LEU   B HD21 1 
ATOM   879  H HD22 . LEU   A 1 55  ? 8.50352   6.33181   26.52953  1.000 23.06312 ? 533 LEU   B HD22 1 
ATOM   880  H HD23 . LEU   A 1 55  ? 8.09490   6.86301   25.08926  1.000 23.06312 ? 533 LEU   B HD23 1 
ATOM   881  N N    . TRP   A 1 56  ? 5.17166   10.25694  27.85487  1.000 12.98653 ? 534 TRP   B N    1 
ATOM   882  C CA   . TRP   A 1 56  ? 4.19961   10.53980  28.89607  1.000 13.80229 ? 534 TRP   B CA   1 
ATOM   883  C C    . TRP   A 1 56  ? 2.81842   10.03649  28.49267  1.000 13.66102 ? 534 TRP   B C    1 
ATOM   884  O O    . TRP   A 1 56  ? 2.14066   9.34686   29.26751  1.000 14.44295 ? 534 TRP   B O    1 
ATOM   885  C CB   . TRP   A 1 56  ? 4.15622   12.05915  29.16512  1.000 15.94567 ? 534 TRP   B CB   1 
ATOM   886  C CG   . TRP   A 1 56  ? 3.11645   12.46273  30.15654  1.000 16.13979 ? 534 TRP   B CG   1 
ATOM   887  C CD1  . TRP   A 1 56  ? 1.89993   13.02151  29.89063  1.000 18.40073 ? 534 TRP   B CD1  1 
ATOM   888  C CD2  . TRP   A 1 56  ? 3.24488   12.45861  31.58701  1.000 17.03851 ? 534 TRP   B CD2  1 
ATOM   889  N NE1  . TRP   A 1 56  ? 1.24150   13.30286  31.06467  1.000 18.67637 ? 534 TRP   B NE1  1 
ATOM   890  C CE2  . TRP   A 1 56  ? 2.05088   12.98575  32.11838  1.000 17.04844 ? 534 TRP   B CE2  1 
ATOM   891  C CE3  . TRP   A 1 56  ? 4.25753   12.07252  32.46502  1.000 17.99352 ? 534 TRP   B CE3  1 
ATOM   892  C CZ2  . TRP   A 1 56  ? 1.84007   13.12033  33.48370  1.000 18.77993 ? 534 TRP   B CZ2  1 
ATOM   893  C CZ3  . TRP   A 1 56  ? 4.02495   12.18320  33.83895  1.000 19.06761 ? 534 TRP   B CZ3  1 
ATOM   894  C CH2  . TRP   A 1 56  ? 2.84066   12.69774  34.32947  1.000 18.16927 ? 534 TRP   B CH2  1 
ATOM   895  H H    . TRP   A 1 56  ? 5.53095   10.95184  27.49763  1.000 15.53785 ? 534 TRP   B H    1 
ATOM   896  H HA   . TRP   A 1 56  ? 4.46606   10.08932  29.71275  1.000 16.51677 ? 534 TRP   B HA   1 
ATOM   897  H HB2  . TRP   A 1 56  ? 5.01856   12.34010  29.50911  1.000 19.08882 ? 534 TRP   B HB2  1 
ATOM   898  H HB3  . TRP   A 1 56  ? 3.96565   12.51843  28.33226  1.000 19.08882 ? 534 TRP   B HB3  1 
ATOM   899  H HD1  . TRP   A 1 56  ? 1.56495   13.18783  29.03915  1.000 22.03489 ? 534 TRP   B HD1  1 
ATOM   900  H HE1  . TRP   A 1 56  ? 0.44714   13.62669  31.12575  1.000 22.36566 ? 534 TRP   B HE1  1 
ATOM   901  H HE3  . TRP   A 1 56  ? 5.06825   11.74913  32.14399  1.000 21.54623 ? 534 TRP   B HE3  1 
ATOM   902  H HZ2  . TRP   A 1 56  ? 1.05065   13.48321  33.81542  1.000 22.48993 ? 534 TRP   B HZ2  1 
ATOM   903  H HZ3  . TRP   A 1 56  ? 4.68165   11.90442  34.43554  1.000 22.83514 ? 534 TRP   B HZ3  1 
ATOM   904  H HH2  . TRP   A 1 56  ? 2.71683   12.75990  35.24909  1.000 21.75714 ? 534 TRP   B HH2  1 
ATOM   905  N N    . GLN   A 1 57  ? 2.41759   10.31838  27.25357  1.000 13.91902 ? 535 GLN   B N    1 
ATOM   906  C CA   . GLN   A 1 57  ? 1.10377   9.89905   26.77655  1.000 14.09697 ? 535 GLN   B CA   1 
ATOM   907  C C    . GLN   A 1 57  ? 0.94044   8.37711   26.84891  1.000 12.93792 ? 535 GLN   B C    1 
ATOM   908  O O    . GLN   A 1 57  ? -0.04891  7.86495   27.37695  1.000 12.90719 ? 535 GLN   B O    1 
ATOM   909  C CB   . GLN   A 1 57  ? 0.90858   10.37904  25.33444  1.000 17.45190 ? 535 GLN   B CB   1 
ATOM   910  C CG   . GLN   A 1 57  ? 0.83259   11.86814  25.14611  1.000 21.86939 ? 535 GLN   B CG   1 
ATOM   911  C CD   . GLN   A 1 57  ? 0.85553   12.29369  23.67379  1.000 28.13740 ? 535 GLN   B CD   1 
ATOM   912  O OE1  . GLN   A 1 57  ? 0.92781   11.44954  22.75978  1.000 26.45392 ? 535 GLN   B OE1  1 
ATOM   913  N NE2  . GLN   A 1 57  ? 0.79245   13.61245  23.43804  1.000 28.86225 ? 535 GLN   B NE2  1 
ATOM   914  H H    . GLN   A 1 57  ? 2.88458   10.74840  26.67339  1.000 16.65684 ? 535 GLN   B H    1 
ATOM   915  H HA   . GLN   A 1 57  ? 0.42482   10.30184  27.34020  1.000 16.87037 ? 535 GLN   B HA   1 
ATOM   916  H HB2  . GLN   A 1 57  ? 1.65546   10.05991  24.80414  1.000 20.89630 ? 535 GLN   B HB2  1 
ATOM   917  H HB3  . GLN   A 1 57  ? 0.07927   10.00412  24.99891  1.000 20.89630 ? 535 GLN   B HB3  1 
ATOM   918  H HG2  . GLN   A 1 57  ? 0.00627   12.19254  25.53707  1.000 26.19728 ? 535 GLN   B HG2  1 
ATOM   919  H HG3  . GLN   A 1 57  ? 1.59225   12.27978  25.58700  1.000 26.19728 ? 535 GLN   B HG3  1 
ATOM   920  H HE21 . GLN   A 1 57  ? 0.74258   14.16486  24.09528  1.000 34.58872 ? 535 GLN   B HE21 1 
ATOM   921  H HE22 . GLN   A 1 57  ? 0.80186   13.90569  22.62964  1.000 34.58872 ? 535 GLN   B HE22 1 
ATOM   922  N N    . SER   A 1 58  ? 1.92261   7.63612   26.32390  1.000 13.13532 ? 536 SER   B N    1 
ATOM   923  C CA   . SER   A 1 58  ? 1.81205   6.17673   26.29811  1.000 13.12027 ? 536 SER   B CA   1 
ATOM   924  C C    . SER   A 1 58  ? 1.85119   5.60974   27.70570  1.000 14.17787 ? 536 SER   B C    1 
ATOM   925  O O    . SER   A 1 58  ? 1.10589   4.67366   28.00582  1.000 13.84805 ? 536 SER   B O    1 
ATOM   926  C CB   . SER   A 1 58  ? 2.94955   5.56742   25.47311  1.000 16.60709 ? 536 SER   B CB   1 
ATOM   927  O OG   . SER   A 1 58  ? 2.75518   5.83717   24.10516  1.000 19.12025 ? 536 SER   B OG   1 
ATOM   928  H H    . SER   A 1 58  ? 2.64811   7.94805   25.98337  1.000 15.71640 ? 536 SER   B H    1 
ATOM   929  H HA   . SER   A 1 58  ? 0.96953   5.94040   25.87953  1.000 15.69834 ? 536 SER   B HA   1 
ATOM   930  H HB2  . SER   A 1 58  ? 3.79214   5.95477   25.75753  1.000 19.88253 ? 536 SER   B HB2  1 
ATOM   931  H HB3  . SER   A 1 58  ? 2.96300   4.60716   25.60960  1.000 19.88253 ? 536 SER   B HB3  1 
ATOM   932  H HG   . SER   A 1 58  ? 2.73779   6.66694   23.97559  1.000 22.89832 ? 536 SER   B HG   1 
ATOM   933  N N    . TYR   A 1 59  ? 2.69736   6.17584   28.57841  1.000 13.04786 ? 537 TYR   B N    1 
ATOM   934  C CA   . TYR   A 1 59  ? 2.72241   5.75590   29.97051  1.000 12.21226 ? 537 TYR   B CA   1 
ATOM   935  C C    . TYR   A 1 59  ? 1.39788   6.03739   30.66037  1.000 13.15150 ? 537 TYR   B C    1 
ATOM   936  O O    . TYR   A 1 59  ? 0.86830   5.19745   31.38834  1.000 13.05630 ? 537 TYR   B O    1 
ATOM   937  C CB   . TYR   A 1 59  ? 3.86579   6.46133   30.72467  1.000 12.56859 ? 537 TYR   B CB   1 
ATOM   938  C CG   . TYR   A 1 59  ? 3.86815   6.14758   32.20230  1.000 13.75486 ? 537 TYR   B CG   1 
ATOM   939  C CD1  . TYR   A 1 59  ? 4.52354   4.99665   32.68747  1.000 13.13593 ? 537 TYR   B CD1  1 
ATOM   940  C CD2  . TYR   A 1 59  ? 3.22943   6.95543   33.12652  1.000 13.36548 ? 537 TYR   B CD2  1 
ATOM   941  C CE1  . TYR   A 1 59  ? 4.51767   4.69257   33.97746  1.000 13.00503 ? 537 TYR   B CE1  1 
ATOM   942  C CE2  . TYR   A 1 59  ? 3.22903   6.63352   34.47968  1.000 12.97732 ? 537 TYR   B CE2  1 
ATOM   943  C CZ   . TYR   A 1 59  ? 3.87271   5.48977   34.89278  1.000 13.94044 ? 537 TYR   B CZ   1 
ATOM   944  O OH   . TYR   A 1 59  ? 3.89605   5.12173   36.21157  1.000 13.47465 ? 537 TYR   B OH   1 
ATOM   945  H H    . TYR   A 1 59  ? 3.25846   6.79812   28.38467  1.000 15.61145 ? 537 TYR   B H    1 
ATOM   946  H HA   . TYR   A 1 59  ? 2.88366   4.79962   29.99162  1.000 14.60873 ? 537 TYR   B HA   1 
ATOM   947  H HB2  . TYR   A 1 59  ? 4.71444   6.17223   30.35438  1.000 15.03632 ? 537 TYR   B HB2  1 
ATOM   948  H HB3  . TYR   A 1 59  ? 3.76822   7.42083   30.62101  1.000 15.03632 ? 537 TYR   B HB3  1 
ATOM   949  H HD1  . TYR   A 1 59  ? 4.96874   4.43996   32.09015  1.000 15.71714 ? 537 TYR   B HD1  1 
ATOM   950  H HD2  . TYR   A 1 59  ? 2.79394   7.72509   32.83863  1.000 15.99259 ? 537 TYR   B HD2  1 
ATOM   951  H HE1  . TYR   A 1 59  ? 4.95755   3.92656   34.26838  1.000 15.56005 ? 537 TYR   B HE1  1 
ATOM   952  H HE2  . TYR   A 1 59  ? 2.80034   7.18281   35.09564  1.000 15.52680 ? 537 TYR   B HE2  1 
ATOM   953  H HH   . TYR   A 1 59  ? 3.45548   5.67007   36.67071  1.000 16.12360 ? 537 TYR   B HH   1 
ATOM   954  N N    . GLN   A 1 60  ? 0.83269   7.23188   30.45535  1.000 11.94912 ? 538 GLN   B N    1 
ATOM   955  C CA   . GLN   A 1 60  ? -0.40174  7.55465   31.14182  1.000 14.07521 ? 538 GLN   B CA   1 
ATOM   956  C C    . GLN   A 1 60  ? -1.55880  6.68559   30.65223  1.000 14.13261 ? 538 GLN   B C    1 
ATOM   957  O O    . GLN   A 1 60  ? -2.47245  6.40298   31.42969  1.000 14.10103 ? 538 GLN   B O    1 
ATOM   958  C CB   . GLN   A 1 60  ? -0.72486  9.02822   30.98217  1.000 15.62474 ? 538 GLN   B CB   1 
ATOM   959  C CG   . GLN   A 1 60  ? 0.19327   9.92820   31.78835  1.000 15.30299 ? 538 GLN   B CG   1 
ATOM   960  C CD   . GLN   A 1 60  ? 0.13795   9.62922   33.29174  1.000 16.63718 ? 538 GLN   B CD   1 
ATOM   961  O OE1  . GLN   A 1 60  ? -0.88565  9.17229   33.82210  1.000 19.42179 ? 538 GLN   B OE1  1 
ATOM   962  N NE2  . GLN   A 1 60  ? 1.24103   9.83992   33.96502  1.000 18.69910 ? 538 GLN   B NE2  1 
ATOM   963  H H    . GLN   A 1 60  ? 1.13990   7.84740   29.93926  1.000 14.29296 ? 538 GLN   B H    1 
ATOM   964  H HA   . GLN   A 1 60  ? -0.28637  7.38579   32.09002  1.000 16.84427 ? 538 GLN   B HA   1 
ATOM   965  H HB2  . GLN   A 1 60  ? -0.63567  9.27033   30.04711  1.000 18.70370 ? 538 GLN   B HB2  1 
ATOM   966  H HB3  . GLN   A 1 60  ? -1.63457  9.18488   31.28012  1.000 18.70370 ? 538 GLN   B HB3  1 
ATOM   967  H HG2  . GLN   A 1 60  ? 1.10685   9.79856   31.48923  1.000 18.31760 ? 538 GLN   B HG2  1 
ATOM   968  H HG3  . GLN   A 1 60  ? -0.07146  10.85185  31.65533  1.000 18.31760 ? 538 GLN   B HG3  1 
ATOM   969  H HE21 . GLN   A 1 60  ? 1.94261   10.13006  33.56103  1.000 22.39293 ? 538 GLN   B HE21 1 
ATOM   970  H HE22 . GLN   A 1 60  ? 1.26395   9.68815   34.81121  1.000 22.39293 ? 538 GLN   B HE22 1 
ATOM   971  N N    . VAL   A 1 61  ? -1.53427  6.26817   29.38203  1.000 13.83128 ? 539 VAL   B N    1 
ATOM   972  C CA   . VAL   A 1 61  ? -2.51932  5.31096   28.89250  1.000 14.71166 ? 539 VAL   B CA   1 
ATOM   973  C C    . VAL   A 1 61  ? -2.40206  3.98830   29.64730  1.000 15.09290 ? 539 VAL   B C    1 
ATOM   974  O O    . VAL   A 1 61  ? -3.40109  3.40206   30.05490  1.000 15.80792 ? 539 VAL   B O    1 
ATOM   975  C CB   . VAL   A 1 61  ? -2.36361  5.10790   27.38042  1.000 15.67111 ? 539 VAL   B CB   1 
ATOM   976  C CG1  . VAL   A 1 61  ? -3.21846  3.95610   26.91398  1.000 17.40847 ? 539 VAL   B CG1  1 
ATOM   977  C CG2  . VAL   A 1 61  ? -2.78591  6.39508   26.64394  1.000 17.78299 ? 539 VAL   B CG2  1 
ATOM   978  H H    . VAL   A 1 61  ? -0.96235  6.52330   28.79262  1.000 16.55155 ? 539 VAL   B H    1 
ATOM   979  H HA   . VAL   A 1 61  ? -3.40413  5.67191   29.05901  1.000 17.60801 ? 539 VAL   B HA   1 
ATOM   980  H HB   . VAL   A 1 61  ? -1.43651  4.90685   27.17803  1.000 18.75935 ? 539 VAL   B HB   1 
ATOM   981  H HG11 . VAL   A 1 61  ? -3.33249  4.01651   25.95260  1.000 20.84418 ? 539 VAL   B HG11 1 
ATOM   982  H HG12 . VAL   A 1 61  ? -2.77795  3.12282   27.14311  1.000 20.84418 ? 539 VAL   B HG12 1 
ATOM   983  H HG13 . VAL   A 1 61  ? -4.08189  4.00549   27.35324  1.000 20.84418 ? 539 VAL   B HG13 1 
ATOM   984  H HG21 . VAL   A 1 61  ? -2.31211  6.44539   25.79902  1.000 21.29360 ? 539 VAL   B HG21 1 
ATOM   985  H HG22 . VAL   A 1 61  ? -3.74255  6.36898   26.48568  1.000 21.29360 ? 539 VAL   B HG22 1 
ATOM   986  H HG23 . VAL   A 1 61  ? -2.56252  7.16174   27.19460  1.000 21.29360 ? 539 VAL   B HG23 1 
ATOM   987  N N    . LYS   A 1 62  ? -1.17336  3.47283   29.79372  1.000 14.55473 ? 540 LYS   B N    1 
ATOM   988  C CA   . LYS   A 1 62  ? -0.97696  2.24132   30.55027  1.000 15.91041 ? 540 LYS   B CA   1 
ATOM   989  C C    . LYS   A 1 62  ? -1.39137  2.38516   32.01055  1.000 14.62986 ? 540 LYS   B C    1 
ATOM   990  O O    . LYS   A 1 62  ? -1.97389  1.46210   32.59898  1.000 15.79449 ? 540 LYS   B O    1 
ATOM   991  C CB   . LYS   A 1 62  ? 0.47566   1.79991   30.47324  1.000 17.96224 ? 540 LYS   B CB   1 
ATOM   992  C CG   . LYS   A 1 62  ? 0.96881   1.44466   29.09357  1.000 23.80205 ? 540 LYS   B CG   1 
ATOM   993  C CD   . LYS   A 1 62  ? 0.16133   0.33600   28.46931  1.000 31.74930 ? 540 LYS   B CD   1 
ATOM   994  C CE   . LYS   A 1 62  ? 1.00216   -0.49173  27.50614  1.000 37.86464 ? 540 LYS   B CE   1 
ATOM   995  N NZ   . LYS   A 1 62  ? 1.25053   -1.86781  28.04197  1.000 47.35901 ? 540 LYS   B NZ   1 
ATOM   996  H H    . LYS   A 1 62  ? -0.45357  3.81379   29.46931  1.000 17.41970 ? 540 LYS   B H    1 
ATOM   997  H HA   . LYS   A 1 62  ? -1.53519  1.55878   30.14602  1.000 19.04650 ? 540 LYS   B HA   1 
ATOM   998  H HB2  . LYS   A 1 62  ? 1.03270   2.52246   30.80269  1.000 21.50871 ? 540 LYS   B HB2  1 
ATOM   999  H HB3  . LYS   A 1 62  ? 0.58659   1.01446   31.03152  1.000 21.50871 ? 540 LYS   B HB3  1 
ATOM   1000 H HG2  . LYS   A 1 62  ? 0.90377   2.22498   28.52105  1.000 28.51648 ? 540 LYS   B HG2  1 
ATOM   1001 H HG3  . LYS   A 1 62  ? 1.89154   1.15104   29.15064  1.000 28.51648 ? 540 LYS   B HG3  1 
ATOM   1002 H HD2  . LYS   A 1 62  ? -0.17098  -0.25124  29.16616  1.000 38.05318 ? 540 LYS   B HD2  1 
ATOM   1003 H HD3  . LYS   A 1 62  ? -0.58100  0.71791   27.97535  1.000 38.05318 ? 540 LYS   B HD3  1 
ATOM   1004 H HE2  . LYS   A 1 62  ? 0.53512   -0.57310  26.65988  1.000 45.39158 ? 540 LYS   B HE2  1 
ATOM   1005 H HE3  . LYS   A 1 62  ? 1.85880   -0.05695  27.37185  1.000 45.39158 ? 540 LYS   B HE3  1 
ATOM   1006 H HZ1  . LYS   A 1 62  ? 1.74629   -2.33318  27.46773  1.000 56.78482 ? 540 LYS   B HZ1  1 
ATOM   1007 H HZ2  . LYS   A 1 62  ? 1.67958   -1.81859  28.82017  1.000 56.78482 ? 540 LYS   B HZ2  1 
ATOM   1008 H HZ3  . LYS   A 1 62  ? 0.47717   -2.29082  28.16477  1.000 56.78482 ? 540 LYS   B HZ3  1 
ATOM   1009 N N    . LYS   A 1 63  ? -1.14012  3.55262   32.60799  1.000 15.56709 ? 541 LYS   B N    1 
ATOM   1010 C CA   . LYS   A 1 63  ? -1.54621  3.73941   33.99739  1.000 14.26301 ? 541 LYS   B CA   1 
ATOM   1011 C C    . LYS   A 1 63  ? -3.06706  3.70123   34.11974  1.000 14.82792 ? 541 LYS   B C    1 
ATOM   1012 O O    . LYS   A 1 63  ? -3.62910  3.05297   35.01550  1.000 13.34986 ? 541 LYS   B O    1 
ATOM   1013 C CB   . LYS   A 1 63  ? -1.00748  5.05968   34.56374  1.000 13.50740 ? 541 LYS   B CB   1 
ATOM   1014 C CG   . LYS   A 1 63  ? -1.43909  5.26230   35.98819  1.000 13.22844 ? 541 LYS   B CG   1 
ATOM   1015 C CD   . LYS   A 1 63  ? -0.75268  6.50152   36.62172  1.000 15.40674 ? 541 LYS   B CD   1 
ATOM   1016 C CE   . LYS   A 1 63  ? -1.11900  6.63290   38.08608  1.000 18.18293 ? 541 LYS   B CE   1 
ATOM   1017 N NZ   . LYS   A 1 63  ? -2.57838  6.78261   38.32972  1.000 18.49231 ? 541 LYS   B NZ   1 
ATOM   1018 H H    . LYS   A 1 63  ? -0.75016  4.22656   32.24285  1.000 18.63452 ? 541 LYS   B H    1 
ATOM   1019 H HA   . LYS   A 1 63  ? -1.16226  3.01962   34.52215  1.000 17.06962 ? 541 LYS   B HA   1 
ATOM   1020 H HB2  . LYS   A 1 63  ? -0.03793  5.04860   34.53638  1.000 16.16290 ? 541 LYS   B HB2  1 
ATOM   1021 H HB3  . LYS   A 1 63  ? -1.34591  5.79804   34.03346  1.000 16.16290 ? 541 LYS   B HB3  1 
ATOM   1022 H HG2  . LYS   A 1 63  ? -2.39910  5.39824   36.01649  1.000 15.82814 ? 541 LYS   B HG2  1 
ATOM   1023 H HG3  . LYS   A 1 63  ? -1.19911  4.48098   36.51056  1.000 15.82814 ? 541 LYS   B HG3  1 
ATOM   1024 H HD2  . LYS   A 1 63  ? 0.21039   6.40840   36.55298  1.000 18.44211 ? 541 LYS   B HD2  1 
ATOM   1025 H HD3  . LYS   A 1 63  ? -1.04228  7.30352   36.15930  1.000 18.44211 ? 541 LYS   B HD3  1 
ATOM   1026 H HE2  . LYS   A 1 63  ? -0.82169  5.83740   38.55477  1.000 21.77353 ? 541 LYS   B HE2  1 
ATOM   1027 H HE3  . LYS   A 1 63  ? -0.67732  7.41646   38.44921  1.000 21.77353 ? 541 LYS   B HE3  1 
ATOM   1028 H HZ1  . LYS   A 1 63  ? -2.73437  6.86622   39.20194  1.000 22.14479 ? 541 LYS   B HZ1  1 
ATOM   1029 H HZ2  . LYS   A 1 63  ? -2.88428  7.50592   37.91096  1.000 22.14479 ? 541 LYS   B HZ2  1 
ATOM   1030 H HZ3  . LYS   A 1 63  ? -3.01264  6.06764   38.02586  1.000 22.14479 ? 541 LYS   B HZ3  1 
ATOM   1031 N N    . ARG   A 1 64  ? -3.75182  4.39899   33.22380  1.000 15.90598 ? 542 ARG   B N    1 
ATOM   1032 C CA   . ARG   A 1 64  ? -5.20834  4.41498   33.28859  1.000 15.36795 ? 542 ARG   B CA   1 
ATOM   1033 C C    . ARG   A 1 64  ? -5.76231  3.00674   33.15041  1.000 16.10973 ? 542 ARG   B C    1 
ATOM   1034 O O    . ARG   A 1 64  ? -6.65468  2.61629   33.88669  1.000 14.24149 ? 542 ARG   B O    1 
ATOM   1035 C CB   . ARG   A 1 64  ? -5.77184  5.30026   32.19052  1.000 18.42049 ? 542 ARG   B CB   1 
ATOM   1036 C CG   . ARG   A 1 64  ? -7.28776  5.16035   32.01047  1.000 20.71021 ? 542 ARG   B CG   1 
ATOM   1037 C CD   . ARG   A 1 64  ? -7.97566  6.47753   31.80731  1.000 29.11997 ? 542 ARG   B CD   1 
ATOM   1038 N NE   . ARG   A 1 64  ? -9.36180  6.30707   31.38001  1.000 27.65082 ? 542 ARG   B NE   1 
ATOM   1039 C CZ   . ARG   A 1 64  ? -10.37132 6.09461   32.20285  1.000 25.24253 ? 542 ARG   B CZ   1 
ATOM   1040 N NH1  . ARG   A 1 64  ? -10.18615 5.94973   33.50351  1.000 24.75666 ? 542 ARG   B NH1  1 
ATOM   1041 N NH2  . ARG   A 1 64  ? -11.59068 5.99099   31.70408  1.000 27.48137 ? 542 ARG   B NH2  1 
ATOM   1042 H H    . ARG   A 1 64  ? -3.40847  4.86030   32.58434  1.000 19.04119 ? 542 ARG   B H    1 
ATOM   1043 H HA   . ARG   A 1 64  ? -5.48195  4.78114   34.14414  1.000 18.39556 ? 542 ARG   B HA   1 
ATOM   1044 H HB2  . ARG   A 1 64  ? -5.58247  6.22654   32.40741  1.000 22.05860 ? 542 ARG   B HB2  1 
ATOM   1045 H HB3  . ARG   A 1 64  ? -5.34953  5.06329   31.35005  1.000 22.05860 ? 542 ARG   B HB3  1 
ATOM   1046 H HG2  . ARG   A 1 64  ? -7.46387  4.60811   31.23271  1.000 24.80626 ? 542 ARG   B HG2  1 
ATOM   1047 H HG3  . ARG   A 1 64  ? -7.66316  4.74626   32.80326  1.000 24.80626 ? 542 ARG   B HG3  1 
ATOM   1048 H HD2  . ARG   A 1 64  ? -7.97396  6.97122   32.64227  1.000 34.89798 ? 542 ARG   B HD2  1 
ATOM   1049 H HD3  . ARG   A 1 64  ? -7.50691  6.98087   31.12333  1.000 34.89798 ? 542 ARG   B HD3  1 
ATOM   1050 H HE   . ARG   A 1 64  ? -9.53102  6.34779   30.53780  1.000 33.13500 ? 542 ARG   B HE   1 
ATOM   1051 H HH11 . ARG   A 1 64  ? -9.39269  5.99316   33.83236  1.000 29.66201 ? 542 ARG   B HH11 1 
ATOM   1052 H HH12 . ARG   A 1 64  ? -10.85913 5.81204   34.02095  1.000 29.66201 ? 542 ARG   B HH12 1 
ATOM   1053 H HH21 . ARG   A 1 64  ? -11.71591 6.06200   30.85621  1.000 32.93166 ? 542 ARG   B HH21 1 
ATOM   1054 H HH22 . ARG   A 1 64  ? -12.25897 5.85254   32.22735  1.000 32.93166 ? 542 ARG   B HH22 1 
ATOM   1055 N N    . GLN   A 1 65  ? -5.19152  2.22244   32.24641  1.000 15.02906 ? 543 GLN   B N    1 
ATOM   1056 C CA   . GLN   A 1 65  ? -5.62891  0.84068   32.05042  1.000 15.08644 ? 543 GLN   B CA   1 
ATOM   1057 C C    . GLN   A 1 65  ? -5.36712  -0.01095  33.28415  1.000 15.71057 ? 543 GLN   B C    1 
ATOM   1058 O O    . GLN   A 1 65  ? -6.18106  -0.86129  33.66152  1.000 15.59285 ? 543 GLN   B O    1 
ATOM   1059 C CB   . GLN   A 1 65  ? -4.92409  0.26229   30.83444  1.000 16.64247 ? 543 GLN   B CB   1 
ATOM   1060 C CG   . GLN   A 1 65  ? -5.29373  0.93511   29.52003  1.000 17.04649 ? 543 GLN   B CG   1 
ATOM   1061 C CD   . GLN   A 1 65  ? -4.49429  0.40754   28.34121  1.000 19.29392 ? 543 GLN   B CD   1 
ATOM   1062 O OE1  . GLN   A 1 65  ? -3.58710  -0.44907  28.49717  1.000 19.28967 ? 543 GLN   B OE1  1 
ATOM   1063 N NE2  . GLN   A 1 65  ? -4.81225  0.89962   27.16520  1.000 17.71071 ? 543 GLN   B NE2  1 
ATOM   1064 H H    . GLN   A 1 65  ? -4.54697  2.46210   31.72997  1.000 17.98889 ? 543 GLN   B H    1 
ATOM   1065 H HA   . GLN   A 1 65  ? -6.58540  0.82785   31.88961  1.000 18.05774 ? 543 GLN   B HA   1 
ATOM   1066 H HB2  . GLN   A 1 65  ? -3.96661  0.35951   30.95566  1.000 19.92497 ? 543 GLN   B HB2  1 
ATOM   1067 H HB3  . GLN   A 1 65  ? -5.15536  -0.67675  30.75952  1.000 19.92497 ? 543 GLN   B HB3  1 
ATOM   1068 H HG2  . GLN   A 1 65  ? -6.23362  0.77831   29.33858  1.000 20.40980 ? 543 GLN   B HG2  1 
ATOM   1069 H HG3  . GLN   A 1 65  ? -5.12456  1.88735   29.59438  1.000 20.40980 ? 543 GLN   B HG3  1 
ATOM   1070 H HE21 . GLN   A 1 65  ? -5.43979  1.48391   27.09895  1.000 21.20687 ? 543 GLN   B HE21 1 
ATOM   1071 H HE22 . GLN   A 1 65  ? -4.39282  0.63743   26.46168  1.000 21.20687 ? 543 GLN   B HE22 1 
ATOM   1072 N N    . MET   A 1 66  ? -4.21255  0.17564   33.92832  1.000 15.68041 ? 544 MET   B N    1 
ATOM   1073 C CA   . MET   A 1 66  ? -3.94164  -0.62969  35.11406  1.000 14.11496 ? 544 MET   B CA   1 
ATOM   1074 C C    . MET   A 1 66  ? -4.81562  -0.17942  36.27697  1.000 15.61083 ? 544 MET   B C    1 
ATOM   1075 O O    . MET   A 1 66  ? -5.25483  -0.99340  37.09308  1.000 16.56431 ? 544 MET   B O    1 
ATOM   1076 C CB   . MET   A 1 66  ? -2.43962  -0.52387  35.47038  1.000 14.00354 ? 544 MET   B CB   1 
ATOM   1077 C CG   . MET   A 1 66  ? -2.00779  -1.56169  36.47947  1.000 15.42019 ? 544 MET   B CG   1 
ATOM   1078 S SD   . MET   A 1 66  ? -0.23030  -1.43131  36.86452  1.000 15.34014 ? 544 MET   B SD   1 
ATOM   1079 C CE   . MET   A 1 66  ? 0.49331   -1.94780  35.31082  1.000 15.62785 ? 544 MET   B CE   1 
ATOM   1080 H H    . MET   A 1 66  ? -3.59904  0.73658   33.70797  1.000 18.77050 ? 544 MET   B H    1 
ATOM   1081 H HA   . MET   A 1 66  ? -4.13485  -1.56180  34.92768  1.000 16.89196 ? 544 MET   B HA   1 
ATOM   1082 H HB2  . MET   A 1 66  ? -1.91389  -0.65002  34.66502  1.000 16.75827 ? 544 MET   B HB2  1 
ATOM   1083 H HB3  . MET   A 1 66  ? -2.26487  0.35291   35.84670  1.000 16.75827 ? 544 MET   B HB3  1 
ATOM   1084 H HG2  . MET   A 1 66  ? -2.50716  -1.43586  37.30149  1.000 18.45824 ? 544 MET   B HG2  1 
ATOM   1085 H HG3  . MET   A 1 66  ? -2.17719  -2.44679  36.12057  1.000 18.45824 ? 544 MET   B HG3  1 
ATOM   1086 H HE1  . MET   A 1 66  ? 1.45655   -1.99948  35.41276  1.000 18.70744 ? 544 MET   B HE1  1 
ATOM   1087 H HE2  . MET   A 1 66  ? 0.13885   -2.81837  35.07129  1.000 18.70744 ? 544 MET   B HE2  1 
ATOM   1088 H HE3  . MET   A 1 66  ? 0.26749   -1.29891  34.62609  1.000 18.70744 ? 544 MET   B HE3  1 
ATOM   1089 N N    . ASP   A 1 67  ? -5.07460  1.11975   36.37328  1.000 16.30205 ? 545 ASP   B N    1 
ATOM   1090 C CA   . ASP   A 1 67  ? -5.98721  1.61503   37.40624  1.000 15.16747 ? 545 ASP   B CA   1 
ATOM   1091 C C    . ASP   A 1 67  ? -7.40265  1.04653   37.20372  1.000 19.74340 ? 545 ASP   B C    1 
ATOM   1092 O O    . ASP   A 1 67  ? -8.07301  0.69008   38.17228  1.000 17.91771 ? 545 ASP   B O    1 
ATOM   1093 C CB   . ASP   A 1 67  ? -6.03539  3.12911   37.40019  1.000 17.07299 ? 545 ASP   B CB   1 
ATOM   1094 C CG   . ASP   A 1 67  ? -4.74268  3.78381   37.91325  1.000 19.55864 ? 545 ASP   B CG   1 
ATOM   1095 O OD1  . ASP   A 1 67  ? -3.93653  3.09043   38.56113  1.000 15.96330 ? 545 ASP   B OD1  1 
ATOM   1096 O OD2  . ASP   A 1 67  ? -4.54745  4.98917   37.62963  1.000 17.39786 ? 545 ASP   B OD2  1 
ATOM   1097 H H    . ASP   A 1 67  ? -4.74303  1.72831   35.86404  1.000 19.51647 ? 545 ASP   B H    1 
ATOM   1098 H HA   . ASP   A 1 67  ? -5.65218  1.33081   38.27104  1.000 18.15498 ? 545 ASP   B HA   1 
ATOM   1099 H HB2  . ASP   A 1 67  ? -6.18260  3.43447   36.49136  1.000 20.44161 ? 545 ASP   B HB2  1 
ATOM   1100 H HB3  . ASP   A 1 67  ? -6.76330  3.42189   37.97056  1.000 20.44161 ? 545 ASP   B HB3  1 
ATOM   1101 N N    . ILE   A 1 68  ? -7.85120  0.92570   35.94742  1.000 16.17037 ? 546 ILE   B N    1 
ATOM   1102 C CA   . ILE   A 1 68  ? -9.13809  0.29224   35.66847  1.000 18.37944 ? 546 ILE   B CA   1 
ATOM   1103 C C    . ILE   A 1 68  ? -9.09828  -1.17211  36.05994  1.000 20.25276 ? 546 ILE   B C    1 
ATOM   1104 O O    . ILE   A 1 68  ? -10.00662 -1.68516  36.73622  1.000 17.52739 ? 546 ILE   B O    1 
ATOM   1105 C CB   . ILE   A 1 68  ? -9.51584  0.44794   34.18402  1.000 17.19706 ? 546 ILE   B CB   1 
ATOM   1106 C CG1  . ILE   A 1 68  ? -9.87546  1.89277   33.86482  1.000 20.08700 ? 546 ILE   B CG1  1 
ATOM   1107 C CG2  . ILE   A 1 68  ? -10.65681 -0.50139  33.82302  1.000 22.67067 ? 546 ILE   B CG2  1 
ATOM   1108 C CD1  . ILE   A 1 68  ? -9.86183  2.18082   32.38512  1.000 19.45869 ? 546 ILE   B CD1  1 
ATOM   1109 H H    . ILE   A 1 68  ? -7.43176  1.20026   35.24864  1.000 19.35846 ? 546 ILE   B H    1 
ATOM   1110 H HA   . ILE   A 1 68  ? -9.81348  0.73937   36.20217  1.000 22.00935 ? 546 ILE   B HA   1 
ATOM   1111 H HB   . ILE   A 1 68  ? -8.74406  0.21229   33.64576  1.000 20.59049 ? 546 ILE   B HB   1 
ATOM   1112 H HG12 . ILE   A 1 68  ? -10.76700 2.07797   34.19912  1.000 24.05842 ? 546 ILE   B HG12 1 
ATOM   1113 H HG13 . ILE   A 1 68  ? -9.23242  2.48036   34.29159  1.000 24.05842 ? 546 ILE   B HG13 1 
ATOM   1114 H HG21 . ILE   A 1 68  ? -11.07932 -0.19135  33.00677  1.000 27.15882 ? 546 ILE   B HG21 1 
ATOM   1115 H HG22 . ILE   A 1 68  ? -10.29660 -1.39234  33.69123  1.000 27.15882 ? 546 ILE   B HG22 1 
ATOM   1116 H HG23 . ILE   A 1 68  ? -11.30215 -0.50929  34.54715  1.000 27.15882 ? 546 ILE   B HG23 1 
ATOM   1117 H HD11 . ILE   A 1 68  ? -10.05760 3.12039   32.24447  1.000 23.30444 ? 546 ILE   B HD11 1 
ATOM   1118 H HD12 . ILE   A 1 68  ? -8.98426  1.96906   32.03024  1.000 23.30444 ? 546 ILE   B HD12 1 
ATOM   1119 H HD13 . ILE   A 1 68  ? -10.53505 1.63403   31.95073  1.000 23.30444 ? 546 ILE   B HD13 1 
ATOM   1120 N N    . LYS   A 1 69  ? -8.06218  -1.87991  35.60029  1.000 17.82146 ? 547 LYS   B N    1 
ATOM   1121 C CA   . LYS   A 1 69  ? -8.03512  -3.32597  35.76674  1.000 19.90407 ? 547 LYS   B CA   1 
ATOM   1122 C C    . LYS   A 1 69  ? -7.89510  -3.72570  37.22284  1.000 22.52764 ? 547 LYS   B C    1 
ATOM   1123 O O    . LYS   A 1 69  ? -8.48756  -4.71910  37.65301  1.000 23.19954 ? 547 LYS   B O    1 
ATOM   1124 C CB   . LYS   A 1 69  ? -6.90965  -3.93067  34.92475  1.000 20.47907 ? 547 LYS   B CB   1 
ATOM   1125 C CG   . LYS   A 1 69  ? -6.80368  -5.44749  35.03689  1.000 28.50249 ? 547 LYS   B CG   1 
ATOM   1126 C CD   . LYS   A 1 69  ? -5.77598  -5.98146  34.03967  1.000 29.61859 ? 547 LYS   B CD   1 
ATOM   1127 C CE   . LYS   A 1 69  ? -5.74869  -7.50206  34.05708  1.000 53.01678 ? 547 LYS   B CE   1 
ATOM   1128 N NZ   . LYS   A 1 69  ? -4.59092  -8.05139  33.29114  1.000 67.44359 ? 547 LYS   B NZ   1 
ATOM   1129 H H    . LYS   A 1 69  ? -7.37799  -1.54989  35.19708  1.000 21.33976 ? 547 LYS   B H    1 
ATOM   1130 H HA   . LYS   A 1 69  ? -8.87678  -3.68700  35.44709  1.000 23.83890 ? 547 LYS   B HA   1 
ATOM   1131 H HB2  . LYS   A 1 69  ? -7.06658  -3.71314  33.99257  1.000 24.52890 ? 547 LYS   B HB2  1 
ATOM   1132 H HB3  . LYS   A 1 69  ? -6.06512  -3.55273  35.21599  1.000 24.52890 ? 547 LYS   B HB3  1 
ATOM   1133 H HG2  . LYS   A 1 69  ? -6.52103  -5.68919  35.93276  1.000 34.15700 ? 547 LYS   B HG2  1 
ATOM   1134 H HG3  . LYS   A 1 69  ? -7.66422  -5.84980  34.84064  1.000 34.15700 ? 547 LYS   B HG3  1 
ATOM   1135 H HD2  . LYS   A 1 69  ? -6.00919  -5.68771  33.14511  1.000 35.49632 ? 547 LYS   B HD2  1 
ATOM   1136 H HD3  . LYS   A 1 69  ? -4.89397  -5.65474  34.27675  1.000 35.49632 ? 547 LYS   B HD3  1 
ATOM   1137 H HE2  . LYS   A 1 69  ? -5.67775  -7.80926  34.97441  1.000 63.57415 ? 547 LYS   B HE2  1 
ATOM   1138 H HE3  . LYS   A 1 69  ? -6.56461  -7.84028  33.65611  1.000 63.57415 ? 547 LYS   B HE3  1 
ATOM   1139 H HZ1  . LYS   A 1 69  ? -3.82710  -7.76443  33.64659  1.000 80.88632 ? 547 LYS   B HZ1  1 
ATOM   1140 H HZ2  . LYS   A 1 69  ? -4.60450  -8.94096  33.31528  1.000 80.88632 ? 547 LYS   B HZ2  1 
ATOM   1141 H HZ3  . LYS   A 1 69  ? -4.63297  -7.78478  32.44306  1.000 80.88632 ? 547 LYS   B HZ3  1 
ATOM   1142 N N    . ASN   A 1 70  ? -7.09444  -2.99857  37.98878  1.000 20.28575 ? 548 ASN   B N    1 
ATOM   1143 C CA   . ASN   A 1 70  ? -6.84210  -3.38260  39.36880  1.000 21.07704 ? 548 ASN   B CA   1 
ATOM   1144 C C    . ASN   A 1 70  ? -7.86405  -2.70169  40.29319  1.000 25.52434 ? 548 ASN   B C    1 
ATOM   1145 O O    . ASN   A 1 70  ? -8.53534  -1.73337  39.93616  1.000 27.69838 ? 548 ASN   B O    1 
ATOM   1146 C CB   . ASN   A 1 70  ? -5.38798  -3.05272  39.77450  1.000 21.50142 ? 548 ASN   B CB   1 
ATOM   1147 C CG   . ASN   A 1 70  ? -4.36007  -3.89087  39.00669  1.000 19.00952 ? 548 ASN   B CG   1 
ATOM   1148 O OD1  . ASN   A 1 70  ? -4.68723  -4.88729  38.36001  1.000 16.88246 ? 548 ASN   B OD1  1 
ATOM   1149 N ND2  . ASN   A 1 70  ? -3.06428  -3.51151  39.10324  1.000 14.12294 ? 548 ASN   B ND2  1 
ATOM   1150 H H    . ASN   A 1 70  ? -6.68888  -2.28421  37.73419  1.000 24.29692 ? 548 ASN   B H    1 
ATOM   1151 H HA   . ASN   A 1 70  ? -6.94430  -4.34127  39.47558  1.000 25.24647 ? 548 ASN   B HA   1 
ATOM   1152 H HB2  . ASN   A 1 70  ? -5.21178  -2.11694  39.58962  1.000 25.75572 ? 548 ASN   B HB2  1 
ATOM   1153 H HB3  . ASN   A 1 70  ? -5.27479  -3.23088  40.72125  1.000 25.75572 ? 548 ASN   B HB3  1 
ATOM   1154 H HD21 . ASN   A 1 70  ? -2.45463  -3.95399  38.68834  1.000 16.90154 ? 548 ASN   B HD21 1 
ATOM   1155 H HD22 . ASN   A 1 70  ? -2.85068  -2.82800  39.57947  1.000 16.90154 ? 548 ASN   B HD22 1 
ATOM   1156 N N    . ASP   A 1 71  ? -7.96094  -3.21205  41.49997  1.000 34.19122 ? 549 ASP   B N    1 
ATOM   1157 C CA   . ASP   A 1 71  ? -9.02522  -2.79913  42.42495  1.000 46.24880 ? 549 ASP   B CA   1 
ATOM   1158 C C    . ASP   A 1 71  ? -8.49829  -1.72390  43.37037  1.000 43.82032 ? 549 ASP   B C    1 
ATOM   1159 O O    . ASP   A 1 71  ? -7.96814  -2.01921  44.44266  1.000 43.16564 ? 549 ASP   B O    1 
ATOM   1160 C CB   . ASP   A 1 71  ? -9.55122  -4.01089  43.19763  1.000 50.45933 ? 549 ASP   B CB   1 
ATOM   1161 C CG   . ASP   A 1 71  ? -10.81457 -3.70702  43.98334  1.000 54.41850 ? 549 ASP   B CG   1 
ATOM   1162 O OD1  . ASP   A 1 71  ? -11.43627 -2.64914  43.73698  1.000 50.02084 ? 549 ASP   B OD1  1 
ATOM   1163 O OD2  . ASP   A 1 71  ? -11.18132 -4.53311  44.84156  1.000 66.68061 ? 549 ASP   B OD2  1 
ATOM   1164 H H    . ASP   A 1 71  ? -7.42499  -3.80358  41.82003  1.000 40.98348 ? 549 ASP   B H    1 
ATOM   1165 H HA   . ASP   A 1 71  ? -9.74204  -2.40092  41.90678  1.000 55.45258 ? 549 ASP   B HA   1 
ATOM   1166 H HB2  . ASP   A 1 71  ? -9.75288  -4.72230  42.56983  1.000 60.50521 ? 549 ASP   B HB2  1 
ATOM   1167 H HB3  . ASP   A 1 71  ? -8.87193  -4.30450  43.82474  1.000 60.50521 ? 549 ASP   B HB3  1 
ATOM   1168 N N    . HIS   A 1 72  ? -8.66858  -0.46327  42.96632  1.000 36.13391 ? 550 HIS   B N    1 
ATOM   1169 C CA   . HIS   A 1 72  ? -8.31996  0.68804   43.80735  1.000 41.97442 ? 550 HIS   B CA   1 
ATOM   1170 C C    . HIS   A 1 72  ? -6.90701  0.55258   44.38295  1.000 40.71825 ? 550 HIS   B C    1 
ATOM   1171 O O    . HIS   A 1 72  ? -6.62612  0.92369   45.52662  1.000 37.97088 ? 550 HIS   B O    1 
ATOM   1172 C CB   . HIS   A 1 72  ? -9.33998  0.87561   44.93907  1.000 43.30732 ? 550 HIS   B CB   1 
ATOM   1173 C CG   . HIS   A 1 72  ? -10.68769 1.32691   44.46931  1.000 43.95551 ? 550 HIS   B CG   1 
ATOM   1174 N ND1  . HIS   A 1 72  ? -10.96515 2.64593   44.17436  1.000 45.58599 ? 550 HIS   B ND1  1 
ATOM   1175 C CD2  . HIS   A 1 72  ? -11.83169 0.63938   44.24238  1.000 42.84087 ? 550 HIS   B CD2  1 
ATOM   1176 C CE1  . HIS   A 1 72  ? -12.22456 2.75016   43.78439  1.000 44.12271 ? 550 HIS   B CE1  1 
ATOM   1177 N NE2  . HIS   A 1 72  ? -12.77366 1.54802   43.82140  1.000 44.42448 ? 550 HIS   B NE2  1 
ATOM   1178 H H    . HIS   A 1 72  ? -8.98868  -0.24398  42.19883  1.000 43.31470 ? 550 HIS   B H    1 
ATOM   1179 H HA   . HIS   A 1 72  ? -8.33638  1.47944   43.24671  1.000 50.32332 ? 550 HIS   B HA   1 
ATOM   1180 H HB2  . HIS   A 1 72  ? -9.45502  0.02906   45.39844  1.000 51.92279 ? 550 HIS   B HB2  1 
ATOM   1181 H HB3  . HIS   A 1 72  ? -9.00232  1.54427   45.55533  1.000 51.92279 ? 550 HIS   B HB3  1 
ATOM   1182 H HD2  . HIS   A 1 72  ? -11.95685 -0.27574  44.35090  1.000 51.36306 ? 550 HIS   B HD2  1 
ATOM   1183 H HE1  . HIS   A 1 72  ? -12.65140 3.53556   43.52776  1.000 52.90126 ? 550 HIS   B HE1  1 
ATOM   1184 H HE2  . HIS   A 1 72  ? -13.58816 1.36421   43.61547  1.000 53.26339 ? 550 HIS   B HE2  1 
ATOM   1185 N N    . LYS   A 1 73  ? -6.00379  0.02698   43.58422  1.000 32.89528 ? 551 LYS   B N    1 
ATOM   1186 C CA   . LYS   A 1 73  ? -4.63546  -0.20478  44.02645  1.000 30.08452 ? 551 LYS   B CA   1 
ATOM   1187 C C    . LYS   A 1 73  ? -3.76358  0.98654   43.65491  1.000 29.00356 ? 551 LYS   B C    1 
ATOM   1188 O O    . LYS   A 1 73  ? -3.92046  1.56853   42.58739  1.000 31.06971 ? 551 LYS   B O    1 
ATOM   1189 C CB   . LYS   A 1 73  ? -4.10588  -1.51307  43.41604  1.000 29.52985 ? 551 LYS   B CB   1 
ATOM   1190 C CG   . LYS   A 1 73  ? -4.69790  -2.72551  44.12357  1.000 35.80131 ? 551 LYS   B CG   1 
ATOM   1191 C CD   . LYS   A 1 73  ? -4.52446  -3.99759  43.33769  1.000 42.35341 ? 551 LYS   B CD   1 
ATOM   1192 C CE   . LYS   A 1 73  ? -5.76555  -4.89726  43.46944  1.000 46.01798 ? 551 LYS   B CE   1 
ATOM   1193 N NZ   . LYS   A 1 73  ? -6.02112  -5.76515  42.24980  1.000 35.63453 ? 551 LYS   B NZ   1 
ATOM   1194 H H    . LYS   A 1 73  ? -6.15535  -0.20842  42.77107  1.000 39.42835 ? 551 LYS   B H    1 
ATOM   1195 H HA   . LYS   A 1 73  ? -4.59272  -0.29232  44.99155  1.000 36.05544 ? 551 LYS   B HA   1 
ATOM   1196 H HB2  . LYS   A 1 73  ? -4.35130  -1.55378  42.47848  1.000 35.38983 ? 551 LYS   B HB2  1 
ATOM   1197 H HB3  . LYS   A 1 73  ? -3.14075  -1.54410  43.50799  1.000 35.38983 ? 551 LYS   B HB3  1 
ATOM   1198 H HG2  . LYS   A 1 73  ? -4.25665  -2.83944  44.97985  1.000 42.91559 ? 551 LYS   B HG2  1 
ATOM   1199 H HG3  . LYS   A 1 73  ? -5.64802  -2.58222  44.25643  1.000 42.91559 ? 551 LYS   B HG3  1 
ATOM   1200 H HD2  . LYS   A 1 73  ? -4.39773  -3.78399  42.40002  1.000 50.77811 ? 551 LYS   B HD2  1 
ATOM   1201 H HD3  . LYS   A 1 73  ? -3.75535  -4.48355  43.67414  1.000 50.77811 ? 551 LYS   B HD3  1 
ATOM   1202 H HE2  . LYS   A 1 73  ? -5.64610  -5.48550  44.23142  1.000 55.17559 ? 551 LYS   B HE2  1 
ATOM   1203 H HE3  . LYS   A 1 73  ? -6.54580  -4.33650  43.60233  1.000 55.17559 ? 551 LYS   B HE3  1 
ATOM   1204 H HZ1  . LYS   A 1 73  ? -6.11410  -5.25444  41.52687  1.000 42.71545 ? 551 LYS   B HZ1  1 
ATOM   1205 H HZ2  . LYS   A 1 73  ? -6.76450  -6.24076  42.36501  1.000 42.71545 ? 551 LYS   B HZ2  1 
ATOM   1206 H HZ3  . LYS   A 1 73  ? -5.33844  -6.32214  42.12410  1.000 42.71545 ? 551 LYS   B HZ3  1 
ATOM   1207 N N    . ASN   A 1 74  ? -2.86141  1.35378   44.55687  1.000 27.75825 ? 552 ASN   B N    1 
ATOM   1208 C CA   . ASN   A 1 74  ? -1.77557  2.27535   44.25476  1.000 24.19378 ? 552 ASN   B CA   1 
ATOM   1209 C C    . ASN   A 1 74  ? -0.83747  1.54098   43.30883  1.000 21.26670 ? 552 ASN   B C    1 
ATOM   1210 O O    . ASN   A 1 74  ? -0.04171  0.70294   43.73997  1.000 20.73505 ? 552 ASN   B O    1 
ATOM   1211 C CB   . ASN   A 1 74  ? -1.07734  2.68909   45.54535  1.000 35.82991 ? 552 ASN   B CB   1 
ATOM   1212 C CG   . ASN   A 1 74  ? -0.15142  3.87548   45.35543  1.000 44.91303 ? 552 ASN   B CG   1 
ATOM   1213 O OD1  . ASN   A 1 74  ? 1.04136   3.71013   45.09725  1.000 57.48618 ? 552 ASN   B OD1  1 
ATOM   1214 N ND2  . ASN   A 1 74  ? -0.69527  5.08173   45.47317  1.000 49.01143 ? 552 ASN   B ND2  1 
ATOM   1215 H H    . ASN   A 1 74  ? -2.85706  1.07582   45.37070  1.000 33.26391 ? 552 ASN   B H    1 
ATOM   1216 H HA   . ASN   A 1 74  ? -2.09888  3.08349   43.82666  1.000 28.98655 ? 552 ASN   B HA   1 
ATOM   1217 H HB2  . ASN   A 1 74  ? -1.74712  2.93330   46.20311  1.000 42.94990 ? 552 ASN   B HB2  1 
ATOM   1218 H HB3  . ASN   A 1 74  ? -0.54813  1.94444   45.87145  1.000 42.94990 ? 552 ASN   B HB3  1 
ATOM   1219 H HD21 . ASN   A 1 74  ? -1.53347  5.16023   45.64884  1.000 58.76773 ? 552 ASN   B HD21 1 
ATOM   1220 H HD22 . ASN   A 1 74  ? -0.20915  5.78416   45.37372  1.000 58.76773 ? 552 ASN   B HD22 1 
ATOM   1221 N N    . ASN   A 1 75  ? -0.97588  1.79984   42.00242  1.000 17.06263 ? 553 ASN   B N    1 
ATOM   1222 C CA   . ASN   A 1 75  ? -0.23216  1.02493   41.01396  1.000 16.67914 ? 553 ASN   B CA   1 
ATOM   1223 C C    . ASN   A 1 75  ? 1.14724   1.59082   40.69223  1.000 15.14333 ? 553 ASN   B C    1 
ATOM   1224 O O    . ASN   A 1 75  ? 1.90726   0.93984   39.97383  1.000 12.85540 ? 553 ASN   B O    1 
ATOM   1225 C CB   . ASN   A 1 75  ? -1.03363  0.91249   39.72735  1.000 15.93597 ? 553 ASN   B CB   1 
ATOM   1226 C CG   . ASN   A 1 75  ? -2.24451  0.01041   39.90036  1.000 17.21376 ? 553 ASN   B CG   1 
ATOM   1227 O OD1  . ASN   A 1 75  ? -2.13381  -1.11296  40.40484  1.000 15.40791 ? 553 ASN   B OD1  1 
ATOM   1228 N ND2  . ASN   A 1 75  ? -3.43153  0.52490   39.53304  1.000 18.39698 ? 553 ASN   B ND2  1 
ATOM   1229 H H    . ASN   A 1 75  ? -1.48638  2.40917   41.67424  1.000 20.42917 ? 553 ASN   B H    1 
ATOM   1230 H HA   . ASN   A 1 75  ? -0.10121  0.13343   41.37309  1.000 19.96898 ? 553 ASN   B HA   1 
ATOM   1231 H HB2  . ASN   A 1 75  ? -1.34441  1.79316   39.46517  1.000 19.07718 ? 553 ASN   B HB2  1 
ATOM   1232 H HB3  . ASN   A 1 75  ? -0.47149  0.53817   39.03108  1.000 19.07718 ? 553 ASN   B HB3  1 
ATOM   1233 H HD21 . ASN   A 1 75  ? -3.47515  1.32465   39.21983  1.000 22.03039 ? 553 ASN   B HD21 1 
ATOM   1234 H HD22 . ASN   A 1 75  ? -4.14698  0.05416   39.61137  1.000 22.03039 ? 553 ASN   B HD22 1 
ATOM   1235 N N    . GLU   A 1 76  ? 1.44117   2.80834   41.14244  1.000 14.82618 ? 554 GLU   B N    1 
ATOM   1236 C CA   . GLU   A 1 76  ? 2.61415   3.54209   40.70773  1.000 14.53214 ? 554 GLU   B CA   1 
ATOM   1237 C C    . GLU   A 1 76  ? 3.52837   3.81142   41.88506  1.000 14.59030 ? 554 GLU   B C    1 
ATOM   1238 O O    . GLU   A 1 76  ? 3.07532   4.23728   42.95281  1.000 15.78547 ? 554 GLU   B O    1 
ATOM   1239 C CB   . GLU   A 1 76  ? 2.21637   4.86679   40.05684  1.000 13.29421 ? 554 GLU   B CB   1 
ATOM   1240 C CG   . GLU   A 1 76  ? 3.38474   5.67547   39.55765  1.000 14.40853 ? 554 GLU   B CG   1 
ATOM   1241 C CD   . GLU   A 1 76  ? 2.88946   6.98075   38.89717  1.000 16.51974 ? 554 GLU   B CD   1 
ATOM   1242 O OE1  . GLU   A 1 76  ? 2.54510   6.95141   37.70496  1.000 14.95549 ? 554 GLU   B OE1  1 
ATOM   1243 O OE2  . GLU   A 1 76  ? 2.83836   8.00966   39.61249  1.000 19.28378 ? 554 GLU   B OE2  1 
ATOM   1244 H H    . GLU   A 1 76  ? 0.96107   3.23556   41.71392  1.000 17.74543 ? 554 GLU   B H    1 
ATOM   1245 H HA   . GLU   A 1 76  ? 3.10044   3.00214   40.06518  1.000 17.39258 ? 554 GLU   B HA   1 
ATOM   1246 H HB2  . GLU   A 1 76  ? 1.64021   4.68073   39.29900  1.000 15.90706 ? 554 GLU   B HB2  1 
ATOM   1247 H HB3  . GLU   A 1 76  ? 1.74206   5.40462   40.71004  1.000 15.90706 ? 554 GLU   B HB3  1 
ATOM   1248 H HG2  . GLU   A 1 76  ? 3.96373   5.90436   40.30147  1.000 17.24425 ? 554 GLU   B HG2  1 
ATOM   1249 H HG3  . GLU   A 1 76  ? 3.87815   5.16218   38.89888  1.000 17.24425 ? 554 GLU   B HG3  1 
ATOM   1250 N N    . ARG   A 1 77  ? 4.80968   3.57378   41.68587  1.000 14.33612 ? 555 ARG   B N    1 
ATOM   1251 C CA   . ARG   A 1 77  ? 5.84102   3.85274   42.66777  1.000 14.93418 ? 555 ARG   B CA   1 
ATOM   1252 C C    . ARG   A 1 77  ? 6.89810   4.71888   41.99558  1.000 14.48212 ? 555 ARG   B C    1 
ATOM   1253 O O    . ARG   A 1 77  ? 7.03044   4.73125   40.77362  1.000 13.99660 ? 555 ARG   B O    1 
ATOM   1254 C CB   . ARG   A 1 77  ? 6.46909   2.55311   43.20076  1.000 16.55175 ? 555 ARG   B CB   1 
ATOM   1255 C CG   . ARG   A 1 77  ? 5.49722   1.71444   44.01716  1.000 18.51047 ? 555 ARG   B CG   1 
ATOM   1256 C CD   . ARG   A 1 77  ? 6.08197   0.36722   44.41945  1.000 21.12045 ? 555 ARG   B CD   1 
ATOM   1257 N NE   . ARG   A 1 77  ? 5.03492   -0.43367  45.05774  1.000 25.51185 ? 555 ARG   B NE   1 
ATOM   1258 C CZ   . ARG   A 1 77  ? 5.03965   -0.78970  46.33198  1.000 28.93455 ? 555 ARG   B CZ   1 
ATOM   1259 N NH1  . ARG   A 1 77  ? 6.09583   -0.57488  47.09515  1.000 23.54945 ? 555 ARG   B NH1  1 
ATOM   1260 N NH2  . ARG   A 1 77  ? 3.95591   -1.37504  46.84830  1.000 31.39449 ? 555 ARG   B NH2  1 
ATOM   1261 H H    . ARG   A 1 77  ? 5.12179   3.23659   40.95890  1.000 17.15736 ? 555 ARG   B H    1 
ATOM   1262 H HA   . ARG   A 1 77  ? 5.47550   4.33261   43.42739  1.000 17.87503 ? 555 ARG   B HA   1 
ATOM   1263 H HB2  . ARG   A 1 77  ? 6.76904   2.01746   42.44975  1.000 19.81611 ? 555 ARG   B HB2  1 
ATOM   1264 H HB3  . ARG   A 1 77  ? 7.22189   2.77766   43.76976  1.000 19.81611 ? 555 ARG   B HB3  1 
ATOM   1265 H HG2  . ARG   A 1 77  ? 5.26624   2.19542   44.82723  1.000 22.16658 ? 555 ARG   B HG2  1 
ATOM   1266 H HG3  . ARG   A 1 77  ? 4.69970   1.55021   43.49001  1.000 22.16658 ? 555 ARG   B HG3  1 
ATOM   1267 H HD2  . ARG   A 1 77  ? 6.40346   -0.10184  43.63362  1.000 25.29855 ? 555 ARG   B HD2  1 
ATOM   1268 H HD3  . ARG   A 1 77  ? 6.80852   0.49660   45.04897  1.000 25.29855 ? 555 ARG   B HD3  1 
ATOM   1269 H HE   . ARG   A 1 77  ? 4.37300   -0.68954  44.57194  1.000 30.56823 ? 555 ARG   B HE   1 
ATOM   1270 H HH11 . ARG   A 1 77  ? 6.79509   -0.19811  46.76547  1.000 28.21335 ? 555 ARG   B HH11 1 
ATOM   1271 H HH12 . ARG   A 1 77  ? 6.08436   -0.81175  47.92180  1.000 28.21335 ? 555 ARG   B HH12 1 
ATOM   1272 H HH21 . ARG   A 1 77  ? 3.26662   -1.51618  46.35377  1.000 37.62741 ? 555 ARG   B HH21 1 
ATOM   1273 H HH22 . ARG   A 1 77  ? 3.94735   -1.61083  47.67530  1.000 37.62741 ? 555 ARG   B HH22 1 
ATOM   1274 N N    . LEU   A 1 78  ? 7.61549   5.50347   42.80683  1.000 14.87915 ? 556 LEU   B N    1 
ATOM   1275 C CA   . LEU   A 1 78  ? 8.70402   6.34203   42.31734  1.000 12.01832 ? 556 LEU   B CA   1 
ATOM   1276 C C    . LEU   A 1 78  ? 9.99681   5.66032   42.68849  1.000 15.31788 ? 556 LEU   B C    1 
ATOM   1277 O O    . LEU   A 1 78  ? 10.32314  5.57924   43.88157  1.000 15.50118 ? 556 LEU   B O    1 
ATOM   1278 C CB   . LEU   A 1 78  ? 8.63315   7.73680   42.94378  1.000 15.49341 ? 556 LEU   B CB   1 
ATOM   1279 C CG   . LEU   A 1 78  ? 9.44352   8.77403   42.22869  1.000 14.57410 ? 556 LEU   B CG   1 
ATOM   1280 C CD1  . LEU   A 1 78  ? 8.86166   9.09388   40.84915  1.000 14.91417 ? 556 LEU   B CD1  1 
ATOM   1281 C CD2  . LEU   A 1 78  ? 9.54928   10.05412  43.08569  1.000 14.44233 ? 556 LEU   B CD2  1 
ATOM   1282 H H    . LEU   A 1 78  ? 7.48520   5.56457   43.65470  1.000 17.80899 ? 556 LEU   B H    1 
ATOM   1283 H HA   . LEU   A 1 78  ? 8.64813   6.43381   41.35331  1.000 14.37600 ? 556 LEU   B HA   1 
ATOM   1284 H HB2  . LEU   A 1 78  ? 7.70880   8.03085   42.94019  1.000 18.54611 ? 556 LEU   B HB2  1 
ATOM   1285 H HB3  . LEU   A 1 78  ? 8.96080   7.68351   43.85520  1.000 18.54611 ? 556 LEU   B HB3  1 
ATOM   1286 H HG   . LEU   A 1 78  ? 10.33619  8.42193   42.08701  1.000 17.44293 ? 556 LEU   B HG   1 
ATOM   1287 H HD11 . LEU   A 1 78  ? 9.31108   9.87496   40.49021  1.000 17.85102 ? 556 LEU   B HD11 1 
ATOM   1288 H HD12 . LEU   A 1 78  ? 9.00149   8.33346   40.26339  1.000 17.85102 ? 556 LEU   B HD12 1 
ATOM   1289 H HD13 . LEU   A 1 78  ? 7.91235   9.27114   40.94017  1.000 17.85102 ? 556 LEU   B HD13 1 
ATOM   1290 H HD21 . LEU   A 1 78  ? 10.07415  10.71335  42.60524  1.000 17.28481 ? 556 LEU   B HD21 1 
ATOM   1291 H HD22 . LEU   A 1 78  ? 8.65749   10.39799  43.25111  1.000 17.28481 ? 556 LEU   B HD22 1 
ATOM   1292 H HD23 . LEU   A 1 78  ? 9.98110   9.83644   43.92655  1.000 17.28481 ? 556 LEU   B HD23 1 
ATOM   1293 N N    . LEU   A 1 79  ? 10.72555  5.19097   41.67100  1.000 12.37414 ? 557 LEU   B N    1 
ATOM   1294 C CA   . LEU   A 1 79  ? 11.87543  4.30276   41.84144  1.000 12.97562 ? 557 LEU   B CA   1 
ATOM   1295 C C    . LEU   A 1 79  ? 13.09515  4.92534   41.14724  1.000 13.52107 ? 557 LEU   B C    1 
ATOM   1296 O O    . LEU   A 1 79  ? 12.99458  5.89796   40.40371  1.000 13.71733 ? 557 LEU   B O    1 
ATOM   1297 C CB   . LEU   A 1 79  ? 11.57845  2.88278   41.28278  1.000 13.63044 ? 557 LEU   B CB   1 
ATOM   1298 C CG   . LEU   A 1 79  ? 10.33827  2.19861   41.90051  1.000 13.10535 ? 557 LEU   B CG   1 
ATOM   1299 C CD1  . LEU   A 1 79  ? 10.04710  0.88683   41.19412  1.000 12.67916 ? 557 LEU   B CD1  1 
ATOM   1300 C CD2  . LEU   A 1 79  ? 10.49682  2.01951   43.40765  1.000 14.26202 ? 557 LEU   B CD2  1 
ATOM   1301 H H    . LEU   A 1 79  ? 10.56638  5.38041   40.84736  1.000 14.80299 ? 557 LEU   B H    1 
ATOM   1302 H HA   . LEU   A 1 79  ? 12.07939  4.20385   42.78458  1.000 15.52476 ? 557 LEU   B HA   1 
ATOM   1303 H HB2  . LEU   A 1 79  ? 11.42992  2.95233   40.32675  1.000 16.31054 ? 557 LEU   B HB2  1 
ATOM   1304 H HB3  . LEU   A 1 79  ? 12.34525  2.31544   41.45899  1.000 16.31054 ? 557 LEU   B HB3  1 
ATOM   1305 H HG   . LEU   A 1 79  ? 9.56486   2.77017   41.77375  1.000 15.68044 ? 557 LEU   B HG   1 
ATOM   1306 H HD11 . LEU   A 1 79  ? 9.26952   0.47443   41.60179  1.000 15.16900 ? 557 LEU   B HD11 1 
ATOM   1307 H HD12 . LEU   A 1 79  ? 9.87377   1.06476   40.25647  1.000 15.16900 ? 557 LEU   B HD12 1 
ATOM   1308 H HD13 . LEU   A 1 79  ? 10.81630  0.30263   41.28326  1.000 15.16900 ? 557 LEU   B HD13 1 
ATOM   1309 H HD21 . LEU   A 1 79  ? 9.74754   1.50405   43.74498  1.000 17.06844 ? 557 LEU   B HD21 1 
ATOM   1310 H HD22 . LEU   A 1 79  ? 11.32727  1.55043   43.58430  1.000 17.06844 ? 557 LEU   B HD22 1 
ATOM   1311 H HD23 . LEU   A 1 79  ? 10.51407  2.89287   43.82938  1.000 17.06844 ? 557 LEU   B HD23 1 
ATOM   1312 N N    . PHE   A 1 80  ? 14.25600  4.29994   41.32613  1.000 12.91201 ? 558 PHE   B N    1 
ATOM   1313 C CA   . PHE   A 1 80  ? 15.49732  4.78771   40.77438  1.000 13.17387 ? 558 PHE   B CA   1 
ATOM   1314 C C    . PHE   A 1 80  ? 16.05021  3.83030   39.73405  1.000 15.51117 ? 558 PHE   B C    1 
ATOM   1315 O O    . PHE   A 1 80  ? 15.79724  2.62416   39.79280  1.000 14.50781 ? 558 PHE   B O    1 
ATOM   1316 C CB   . PHE   A 1 80  ? 16.54927  4.96526   41.86906  1.000 15.15518 ? 558 PHE   B CB   1 
ATOM   1317 C CG   . PHE   A 1 80  ? 16.19629  5.99430   42.89888  1.000 15.08403 ? 558 PHE   B CG   1 
ATOM   1318 C CD1  . PHE   A 1 80  ? 16.43037  7.34043   42.64788  1.000 14.67786 ? 558 PHE   B CD1  1 
ATOM   1319 C CD2  . PHE   A 1 80  ? 15.64967  5.61480   44.11268  1.000 14.77175 ? 558 PHE   B CD2  1 
ATOM   1320 C CE1  . PHE   A 1 80  ? 16.14525  8.27428   43.61662  1.000 17.79232 ? 558 PHE   B CE1  1 
ATOM   1321 C CE2  . PHE   A 1 80  ? 15.31391  6.56748   45.07795  1.000 20.10533 ? 558 PHE   B CE2  1 
ATOM   1322 C CZ   . PHE   A 1 80  ? 15.57289  7.89712   44.82402  1.000 16.77533 ? 558 PHE   B CZ   1 
ATOM   1323 H H    . PHE   A 1 80  ? 14.34294  3.57262   41.77674  1.000 15.44843 ? 558 PHE   B H    1 
ATOM   1324 H HA   . PHE   A 1 80  ? 15.32470  5.64060   40.34579  1.000 15.76266 ? 558 PHE   B HA   1 
ATOM   1325 H HB2  . PHE   A 1 80  ? 16.66591  4.11838   42.32741  1.000 18.14023 ? 558 PHE   B HB2  1 
ATOM   1326 H HB3  . PHE   A 1 80  ? 17.38392  5.23668   41.45605  1.000 18.14023 ? 558 PHE   B HB3  1 
ATOM   1327 H HD1  . PHE   A 1 80  ? 16.77837  7.60903   41.82834  1.000 17.56745 ? 558 PHE   B HD1  1 
ATOM   1328 H HD2  . PHE   A 1 80  ? 15.50389  4.71320   44.28809  1.000 17.68011 ? 558 PHE   B HD2  1 
ATOM   1329 H HE1  . PHE   A 1 80  ? 16.33849  9.17053   43.46076  1.000 21.30479 ? 558 PHE   B HE1  1 
ATOM   1330 H HE2  . PHE   A 1 80  ? 14.92137  6.30815   45.88017  1.000 24.08041 ? 558 PHE   B HE2  1 
ATOM   1331 H HZ   . PHE   A 1 80  ? 15.36429  8.54156   45.46127  1.000 20.08441 ? 558 PHE   B HZ   1 
ATOM   1332 N N    . HIS   A 1 81  ? 16.79468  4.38153   38.76826  1.000 13.27459 ? 559 HIS   B N    1 
ATOM   1333 C CA   . HIS   A 1 81  ? 17.44908  3.53921   37.76531  1.000 13.71835 ? 559 HIS   B CA   1 
ATOM   1334 C C    . HIS   A 1 81  ? 18.77829  4.17104   37.41676  1.000 15.54372 ? 559 HIS   B C    1 
ATOM   1335 O O    . HIS   A 1 81  ? 18.80321  5.20279   36.74892  1.000 13.69309 ? 559 HIS   B O    1 
ATOM   1336 C CB   . HIS   A 1 81  ? 16.59447  3.40289   36.52345  1.000 12.45878 ? 559 HIS   B CB   1 
ATOM   1337 C CG   . HIS   A 1 81  ? 17.17698  2.54670   35.44854  1.000 16.59499 ? 559 HIS   B CG   1 
ATOM   1338 N ND1  . HIS   A 1 81  ? 16.85748  1.21210   35.31139  1.000 16.90780 ? 559 HIS   B ND1  1 
ATOM   1339 C CD2  . HIS   A 1 81  ? 18.04820  2.82196   34.45417  1.000 16.65882 ? 559 HIS   B CD2  1 
ATOM   1340 C CE1  . HIS   A 1 81  ? 17.48278  0.70502   34.26211  1.000 15.47688 ? 559 HIS   B CE1  1 
ATOM   1341 N NE2  . HIS   A 1 81  ? 18.24642  1.64893   33.74424  1.000 15.72040 ? 559 HIS   B NE2  1 
ATOM   1342 H H    . HIS   A 1 81  ? 16.93236  5.22539   38.67577  1.000 15.88353 ? 559 HIS   B H    1 
ATOM   1343 H HA   . HIS   A 1 81  ? 17.60386  2.65937   38.14322  1.000 16.41603 ? 559 HIS   B HA   1 
ATOM   1344 H HB2  . HIS   A 1 81  ? 15.74370  3.01226   36.77741  1.000 14.90455 ? 559 HIS   B HB2  1 
ATOM   1345 H HB3  . HIS   A 1 81  ? 16.45502  4.28636   36.14804  1.000 14.90455 ? 559 HIS   B HB3  1 
ATOM   1346 H HD1  . HIS   A 1 81  ? 16.33000  0.77462   35.83098  1.000 20.24338 ? 559 HIS   B HD1  1 
ATOM   1347 H HD2  . HIS   A 1 81  ? 18.44201  3.64595   34.27855  1.000 19.94460 ? 559 HIS   B HD2  1 
ATOM   1348 H HE1  . HIS   A 1 81  ? 17.39904  -0.16503  33.94448  1.000 18.52627 ? 559 HIS   B HE1  1 
ATOM   1349 N N    . GLY   A 1 82  ? 19.86755  3.49629   37.76677  1.000 14.42894 ? 560 GLY   B N    1 
ATOM   1350 C CA   . GLY   A 1 82  ? 21.20259  3.96412   37.38060  1.000 16.73253 ? 560 GLY   B CA   1 
ATOM   1351 C C    . GLY   A 1 82  ? 21.56363  3.42984   36.00221  1.000 17.65474 ? 560 GLY   B C    1 
ATOM   1352 O O    . GLY   A 1 82  ? 21.28935  2.26151   35.66842  1.000 18.37462 ? 560 GLY   B O    1 
ATOM   1353 H H    . GLY   A 1 82  ? 19.86481  2.76860   38.22508  1.000 17.26874 ? 560 GLY   B H    1 
ATOM   1354 H HA2  . GLY   A 1 82  ? 21.21902  4.93370   37.35731  1.000 20.03305 ? 560 GLY   B HA2  1 
ATOM   1355 H HA3  . GLY   A 1 82  ? 21.86023  3.65244   38.02189  1.000 20.03305 ? 560 GLY   B HA3  1 
ATOM   1356 N N    . THR   A 1 83  ? 22.21460  4.27511   35.20393  1.000 16.84156 ? 561 THR   B N    1 
ATOM   1357 C CA   . THR   A 1 83  ? 22.68832  3.77960   33.91576  1.000 18.55100 ? 561 THR   B CA   1 
ATOM   1358 C C    . THR   A 1 83  ? 23.92517  4.54608   33.47252  1.000 18.78468 ? 561 THR   B C    1 
ATOM   1359 O O    . THR   A 1 83  ? 24.34801  5.53357   34.09817  1.000 16.17968 ? 561 THR   B O    1 
ATOM   1360 C CB   . THR   A 1 83  ? 21.57702  3.84495   32.86901  1.000 23.32998 ? 561 THR   B CB   1 
ATOM   1361 O OG1  . THR   A 1 83  ? 21.91481  2.99629   31.76354  1.000 22.94399 ? 561 THR   B OG1  1 
ATOM   1362 C CG2  . THR   A 1 83  ? 21.39147  5.25572   32.37992  1.000 19.47149 ? 561 THR   B CG2  1 
ATOM   1363 H H    . THR   A 1 83  ? 22.38527  5.09971   35.37861  1.000 20.16389 ? 561 THR   B H    1 
ATOM   1364 H HA   . THR   A 1 83  ? 22.96499  2.85569   34.01934  1.000 22.21521 ? 561 THR   B HA   1 
ATOM   1365 H HB   . THR   A 1 83  ? 20.74129  3.54897   33.26253  1.000 27.94999 ? 561 THR   B HB   1 
ATOM   1366 H HG1  . THR   A 1 83  ? 22.00393  2.20356   32.02666  1.000 27.48680 ? 561 THR   B HG1  1 
ATOM   1367 H HG21 . THR   A 1 83  ? 20.52355  5.34874   31.95689  1.000 23.31980 ? 561 THR   B HG21 1 
ATOM   1368 H HG22 . THR   A 1 83  ? 21.44675  5.87495   33.12450  1.000 23.31980 ? 561 THR   B HG22 1 
ATOM   1369 H HG23 . THR   A 1 83  ? 22.08138  5.47665   31.73486  1.000 23.31980 ? 561 THR   B HG23 1 
ATOM   1370 N N    . ASP   A 1 84  ? 24.49648  4.08365   32.36603  1.000 18.63025 ? 562 ASP   B N    1 
ATOM   1371 C CA   . ASP   A 1 84  ? 25.72138  4.66919   31.84608  1.000 19.24137 ? 562 ASP   B CA   1 
ATOM   1372 C C    . ASP   A 1 84  ? 25.40496  5.85968   30.95322  1.000 19.85403 ? 562 ASP   B C    1 
ATOM   1373 O O    . ASP   A 1 84  ? 24.27704  6.03149   30.45211  1.000 18.79389 ? 562 ASP   B O    1 
ATOM   1374 C CB   . ASP   A 1 84  ? 26.53236  3.62357   31.07604  1.000 21.91530 ? 562 ASP   B CB   1 
ATOM   1375 C CG   . ASP   A 1 84  ? 25.78378  3.08270   29.86522  1.000 28.94416 ? 562 ASP   B CG   1 
ATOM   1376 O OD1  . ASP   A 1 84  ? 24.60929  2.73721   30.00417  1.000 33.96509 ? 562 ASP   B OD1  1 
ATOM   1377 O OD2  . ASP   A 1 84  ? 26.38178  2.98351   28.79366  1.000 37.72755 ? 562 ASP   B OD2  1 
ATOM   1378 H H    . ASP   A 1 84  ? 24.19136  3.42950   31.89849  1.000 22.31031 ? 562 ASP   B H    1 
ATOM   1379 H HA   . ASP   A 1 84  ? 26.26747  4.98466   32.58307  1.000 23.04365 ? 562 ASP   B HA   1 
ATOM   1380 H HB2  . ASP   A 1 84  ? 27.35694  4.02823   30.76427  1.000 26.25237 ? 562 ASP   B HB2  1 
ATOM   1381 H HB3  . ASP   A 1 84  ? 26.73032  2.87879   31.66512  1.000 26.25237 ? 562 ASP   B HB3  1 
ATOM   1382 N N    . ALA   A 1 85  ? 26.41746  6.70754   30.76129  1.000 17.86964 ? 563 ALA   B N    1 
ATOM   1383 C CA   . ALA   A 1 85  ? 26.20657  7.90623   29.96711  1.000 18.30523 ? 563 ALA   B CA   1 
ATOM   1384 C C    . ALA   A 1 85  ? 25.78210  7.58866   28.54865  1.000 19.47074 ? 563 ALA   B C    1 
ATOM   1385 O O    . ALA   A 1 85  ? 24.97406  8.31144   27.96816  1.000 20.23500 ? 563 ALA   B O    1 
ATOM   1386 C CB   . ALA   A 1 85  ? 27.48029  8.75843   29.94001  1.000 18.38701 ? 563 ALA   B CB   1 
ATOM   1387 H H    . ALA   A 1 85  ? 27.21299  6.61068   31.07329  1.000 21.39758 ? 563 ALA   B H    1 
ATOM   1388 H HA   . ALA   A 1 85  ? 25.49562  8.41363   30.38901  1.000 21.92030 ? 563 ALA   B HA   1 
ATOM   1389 H HB1  . ALA   A 1 85  ? 27.31871  9.55090   29.40450  1.000 22.01842 ? 563 ALA   B HB1  1 
ATOM   1390 H HB2  . ALA   A 1 85  ? 27.70901  9.01344   30.84752  1.000 22.01842 ? 563 ALA   B HB2  1 
ATOM   1391 H HB3  . ALA   A 1 85  ? 28.20045  8.23770   29.55128  1.000 22.01842 ? 563 ALA   B HB3  1 
ATOM   1392 N N    . ASP   A 1 86  ? 26.33758  6.53607   27.95696  1.000 20.25550 ? 564 ASP   B N    1 
ATOM   1393 C CA   . ASP   A 1 86  ? 26.00564  6.19011   26.58175  1.000 24.99792 ? 564 ASP   B CA   1 
ATOM   1394 C C    . ASP   A 1 86  ? 24.50931  5.92367   26.40059  1.000 23.61922 ? 564 ASP   B C    1 
ATOM   1395 O O    . ASP   A 1 86  ? 23.98363  6.10106   25.30098  1.000 26.64451 ? 564 ASP   B O    1 
ATOM   1396 C CB   . ASP   A 1 86  ? 26.78930  4.94215   26.14306  1.000 28.53659 ? 564 ASP   B CB   1 
ATOM   1397 C CG   . ASP   A 1 86  ? 28.24308  5.25657   25.80145  1.000 33.08201 ? 564 ASP   B CG   1 
ATOM   1398 O OD1  . ASP   A 1 86  ? 28.51889  6.36349   25.30910  1.000 31.74450 ? 564 ASP   B OD1  1 
ATOM   1399 O OD2  . ASP   A 1 86  ? 29.10153  4.38755   26.01820  1.000 34.10030 ? 564 ASP   B OD2  1 
ATOM   1400 H H    . ASP   A 1 86  ? 26.90670  6.00862   28.32777  1.000 24.26061 ? 564 ASP   B H    1 
ATOM   1401 H HA   . ASP   A 1 86  ? 26.25895  6.93827   26.01872  1.000 29.95152 ? 564 ASP   B HA   1 
ATOM   1402 H HB2  . ASP   A 1 86  ? 26.78291  4.29374   26.86447  1.000 34.19792 ? 564 ASP   B HB2  1 
ATOM   1403 H HB3  . ASP   A 1 86  ? 26.36937  4.56494   25.35422  1.000 34.19792 ? 564 ASP   B HB3  1 
ATOM   1404 N N    . SER   A 1 87  ? 23.81229  5.52667   27.46313  1.000 19.10814 ? 565 SER   B N    1 
ATOM   1405 C CA   . SER   A 1 87  ? 22.40108  5.18609   27.36900  1.000 20.22354 ? 565 SER   B CA   1 
ATOM   1406 C C    . SER   A 1 87  ? 21.45651  6.35432   27.63755  1.000 20.08861 ? 565 SER   B C    1 
ATOM   1407 O O    . SER   A 1 87  ? 20.26984  6.25156   27.30858  1.000 18.86727 ? 565 SER   B O    1 
ATOM   1408 C CB   . SER   A 1 87  ? 22.07116  4.05738   28.35061  1.000 21.46020 ? 565 SER   B CB   1 
ATOM   1409 O OG   . SER   A 1 87  ? 22.70708  2.86430   27.98768  1.000 23.86803 ? 565 SER   B OG   1 
ATOM   1410 H H    . SER   A 1 87  ? 24.13956  5.44691   28.25442  1.000 22.88378 ? 565 SER   B H    1 
ATOM   1411 H HA   . SER   A 1 87  ? 22.23194  4.87854   26.46473  1.000 24.22226 ? 565 SER   B HA   1 
ATOM   1412 H HB2  . SER   A 1 87  ? 22.36974  4.31504   29.23682  1.000 25.70626 ? 565 SER   B HB2  1 
ATOM   1413 H HB3  . SER   A 1 87  ? 21.11188  3.91362   28.35248  1.000 25.70626 ? 565 SER   B HB3  1 
ATOM   1414 H HG   . SER   A 1 87  ? 23.54001  2.97291   27.98197  1.000 28.59565 ? 565 SER   B HG   1 
ATOM   1415 N N    . VAL   A 1 88  ? 21.96099  7.45222   28.19546  1.000 18.87001 ? 566 VAL   B N    1 
ATOM   1416 C CA   . VAL   A 1 88  ? 21.08675  8.55894   28.59225  1.000 17.65152 ? 566 VAL   B CA   1 
ATOM   1417 C C    . VAL   A 1 88  ? 20.32304  9.15437   27.41453  1.000 15.69569 ? 566 VAL   B C    1 
ATOM   1418 O O    . VAL   A 1 88  ? 19.11221  9.37346   27.54469  1.000 14.61490 ? 566 VAL   B O    1 
ATOM   1419 C CB   . VAL   A 1 88  ? 21.90274  9.61056   29.36181  1.000 16.64230 ? 566 VAL   B CB   1 
ATOM   1420 C CG1  . VAL   A 1 88  ? 21.20136  10.96561  29.41619  1.000 14.79316 ? 566 VAL   B CG1  1 
ATOM   1421 C CG2  . VAL   A 1 88  ? 22.20577  9.10057   30.77375  1.000 18.06800 ? 566 VAL   B CG2  1 
ATOM   1422 H H    . VAL   A 1 88  ? 22.79590  7.58316   28.35478  1.000 22.59803 ? 566 VAL   B H    1 
ATOM   1423 H HA   . VAL   A 1 88  ? 20.42354  8.19310   29.19823  1.000 21.13584 ? 566 VAL   B HA   1 
ATOM   1424 H HB   . VAL   A 1 88  ? 22.73657  9.75107   28.88655  1.000 19.92477 ? 566 VAL   B HB   1 
ATOM   1425 H HG11 . VAL   A 1 88  ? 21.61998  11.51064  30.10073  1.000 17.70581 ? 566 VAL   B HG11 1 
ATOM   1426 H HG12 . VAL   A 1 88  ? 21.28377  11.39876  28.55219  1.000 17.70581 ? 566 VAL   B HG12 1 
ATOM   1427 H HG13 . VAL   A 1 88  ? 20.26510  10.82826  29.62939  1.000 17.70581 ? 566 VAL   B HG13 1 
ATOM   1428 H HG21 . VAL   A 1 88  ? 22.72914  9.76764   31.24491  1.000 21.63562 ? 566 VAL   B HG21 1 
ATOM   1429 H HG22 . VAL   A 1 88  ? 21.36933  8.94643   31.24013  1.000 21.63562 ? 566 VAL   B HG22 1 
ATOM   1430 H HG23 . VAL   A 1 88  ? 22.70628  8.27215   30.70965  1.000 21.63562 ? 566 VAL   B HG23 1 
ATOM   1431 N N    . PRO   A 1 89  ? 20.93945  9.44011   26.26913  1.000 16.11628 ? 567 PRO   B N    1 
ATOM   1432 C CA   . PRO   A 1 89  ? 20.15643  10.03101  25.16576  1.000 18.62083 ? 567 PRO   B CA   1 
ATOM   1433 C C    . PRO   A 1 89  ? 19.00958  9.12726   24.70421  1.000 19.86362 ? 567 PRO   B C    1 
ATOM   1434 O O    . PRO   A 1 89  ? 17.92054  9.63478   24.43201  1.000 16.47266 ? 567 PRO   B O    1 
ATOM   1435 C CB   . PRO   A 1 89  ? 21.19846  10.25480  24.05683  1.000 20.52930 ? 567 PRO   B CB   1 
ATOM   1436 C CG   . PRO   A 1 89  ? 22.54300  10.33672  24.81574  1.000 20.94306 ? 567 PRO   B CG   1 
ATOM   1437 C CD   . PRO   A 1 89  ? 22.38437  9.35622   25.96415  1.000 20.17334 ? 567 PRO   B CD   1 
ATOM   1438 H HA   . PRO   A 1 89  ? 19.80440  10.89316  25.43718  1.000 22.29901 ? 567 PRO   B HA   1 
ATOM   1439 H HB2  . PRO   A 1 89  ? 21.19106  9.50930   23.43628  1.000 24.58918 ? 567 PRO   B HB2  1 
ATOM   1440 H HB3  . PRO   A 1 89  ? 21.01147  11.08128  23.58475  1.000 24.58918 ? 567 PRO   B HB3  1 
ATOM   1441 H HG2  . PRO   A 1 89  ? 23.27220  10.07577  24.23172  1.000 25.08569 ? 567 PRO   B HG2  1 
ATOM   1442 H HG3  . PRO   A 1 89  ? 22.68677  11.23831  25.14342  1.000 25.08569 ? 567 PRO   B HG3  1 
ATOM   1443 H HD2  . PRO   A 1 89  ? 22.62988  8.45855   25.69062  1.000 24.16202 ? 567 PRO   B HD2  1 
ATOM   1444 H HD3  . PRO   A 1 89  ? 22.91676  9.62749   26.72827  1.000 24.16202 ? 567 PRO   B HD3  1 
ATOM   1445 N N    . TYR   A 1 90  ? 19.21895  7.80633   24.64895  1.000 16.82031 ? 568 TYR   B N    1 
ATOM   1446 C CA   . TYR   A 1 90  ? 18.14553  6.88597   24.25814  1.000 17.99169 ? 568 TYR   B CA   1 
ATOM   1447 C C    . TYR   A 1 90  ? 17.03928  6.85440   25.30822  1.000 16.93782 ? 568 TYR   B C    1 
ATOM   1448 O O    . TYR   A 1 90  ? 15.84042  6.92582   24.98083  1.000 17.51523 ? 568 TYR   B O    1 
ATOM   1449 C CB   . TYR   A 1 90  ? 18.70107  5.47627   24.03258  1.000 18.65821 ? 568 TYR   B CB   1 
ATOM   1450 C CG   . TYR   A 1 90  ? 17.60975  4.47188   23.67219  1.000 19.11566 ? 568 TYR   B CG   1 
ATOM   1451 C CD1  . TYR   A 1 90  ? 16.89389  3.83300   24.66809  1.000 19.94931 ? 568 TYR   B CD1  1 
ATOM   1452 C CD2  . TYR   A 1 90  ? 17.27034  4.23824   22.35735  1.000 21.57654 ? 568 TYR   B CD2  1 
ATOM   1453 C CE1  . TYR   A 1 90  ? 15.86335  2.95853   24.35199  1.000 20.48937 ? 568 TYR   B CE1  1 
ATOM   1454 C CE2  . TYR   A 1 90  ? 16.24128  3.35805   22.02602  1.000 22.53882 ? 568 TYR   B CE2  1 
ATOM   1455 C CZ   . TYR   A 1 90  ? 15.55516  2.71913   23.03350  1.000 21.72641 ? 568 TYR   B CZ   1 
ATOM   1456 O OH   . TYR   A 1 90  ? 14.50823  1.84822   22.74948  1.000 22.53640 ? 568 TYR   B OH   1 
ATOM   1457 H H    . TYR   A 1 90  ? 19.96598  7.42110   24.83103  1.000 20.13838 ? 568 TYR   B H    1 
ATOM   1458 H HA   . TYR   A 1 90  ? 17.76783  7.19748   23.42076  1.000 21.54404 ? 568 TYR   B HA   1 
ATOM   1459 H HB2  . TYR   A 1 90  ? 19.34139  5.50054   23.30436  1.000 22.34386 ? 568 TYR   B HB2  1 
ATOM   1460 H HB3  . TYR   A 1 90  ? 19.13446  5.17241   24.84544  1.000 22.34386 ? 568 TYR   B HB3  1 
ATOM   1461 H HD1  . TYR   A 1 90  ? 17.10538  3.99106   25.55982  1.000 23.89319 ? 568 TYR   B HD1  1 
ATOM   1462 H HD2  . TYR   A 1 90  ? 17.73509  4.67462   21.68024  1.000 25.84586 ? 568 TYR   B HD2  1 
ATOM   1463 H HE1  . TYR   A 1 90  ? 15.38396  2.53687   25.02822  1.000 24.54126 ? 568 TYR   B HE1  1 
ATOM   1464 H HE2  . TYR   A 1 90  ? 16.02126  3.20458   21.13555  1.000 27.00060 ? 568 TYR   B HE2  1 
ATOM   1465 H HH   . TYR   A 1 90  ? 14.40435  1.78526   21.91831  1.000 26.99769 ? 568 TYR   B HH   1 
ATOM   1466 N N    . VAL   A 1 91  ? 17.41282  6.75906   26.58682  1.000 15.72285 ? 569 VAL   B N    1 
ATOM   1467 C CA   . VAL   A 1 91  ? 16.39021  6.70035   27.62896  1.000 15.38912 ? 569 VAL   B CA   1 
ATOM   1468 C C    . VAL   A 1 91  ? 15.56818  7.99234   27.63750  1.000 15.02036 ? 569 VAL   B C    1 
ATOM   1469 O O    . VAL   A 1 91  ? 14.34430  7.96650   27.74905  1.000 13.98331 ? 569 VAL   B O    1 
ATOM   1470 C CB   . VAL   A 1 91  ? 17.02718  6.41815   29.00351  1.000 14.92393 ? 569 VAL   B CB   1 
ATOM   1471 C CG1  . VAL   A 1 91  ? 16.01560  6.58564   30.11931  1.000 15.60417 ? 569 VAL   B CG1  1 
ATOM   1472 C CG2  . VAL   A 1 91  ? 17.62443  5.01486   29.01249  1.000 17.83647 ? 569 VAL   B CG2  1 
ATOM   1473 H H    . VAL   A 1 91  ? 18.22528  6.72771   26.86703  1.000 18.82143 ? 569 VAL   B H    1 
ATOM   1474 H HA   . VAL   A 1 91  ? 15.79131  5.96389   27.42932  1.000 18.42096 ? 569 VAL   B HA   1 
ATOM   1475 H HB   . VAL   A 1 91  ? 17.73714  7.05948   29.16338  1.000 17.86273 ? 569 VAL   B HB   1 
ATOM   1476 H HG11 . VAL   A 1 91  ? 16.36208  6.17055   30.92463  1.000 18.67901 ? 569 VAL   B HG11 1 
ATOM   1477 H HG12 . VAL   A 1 91  ? 15.86792  7.53206   30.27224  1.000 18.67901 ? 569 VAL   B HG12 1 
ATOM   1478 H HG13 . VAL   A 1 91  ? 15.18436  6.15904   29.85863  1.000 18.67901 ? 569 VAL   B HG13 1 
ATOM   1479 H HG21 . VAL   A 1 91  ? 18.01372  4.84290   29.88415  1.000 21.35778 ? 569 VAL   B HG21 1 
ATOM   1480 H HG22 . VAL   A 1 91  ? 16.92159  4.37135   28.83135  1.000 21.35778 ? 569 VAL   B HG22 1 
ATOM   1481 H HG23 . VAL   A 1 91  ? 18.30898  4.95860   28.32756  1.000 21.35778 ? 569 VAL   B HG23 1 
ATOM   1482 N N    . ASN   A 1 92  ? 16.23208  9.14026   27.50098  1.000 15.17511 ? 570 ASN   B N    1 
ATOM   1483 C CA   . ASN   A 1 92  ? 15.51451  10.40618  27.52296  1.000 14.80338 ? 570 ASN   B CA   1 
ATOM   1484 C C    . ASN   A 1 92  ? 14.43577  10.42445  26.45601  1.000 16.28227 ? 570 ASN   B C    1 
ATOM   1485 O O    . ASN   A 1 92  ? 13.34818  10.98599  26.67061  1.000 15.44382 ? 570 ASN   B O    1 
ATOM   1486 C CB   . ASN   A 1 92  ? 16.48952  11.57444  27.29104  1.000 15.31697 ? 570 ASN   B CB   1 
ATOM   1487 C CG   . ASN   A 1 92  ? 17.45018  11.80091  28.42567  1.000 15.20481 ? 570 ASN   B CG   1 
ATOM   1488 O OD1  . ASN   A 1 92  ? 17.32472  11.24656  29.51378  1.000 14.69893 ? 570 ASN   B OD1  1 
ATOM   1489 N ND2  . ASN   A 1 92  ? 18.45293  12.70102  28.17336  1.000 17.14959 ? 570 ASN   B ND2  1 
ATOM   1490 H H    . ASN   A 1 92  ? 17.08286  9.20960   27.39625  1.000 18.16414 ? 570 ASN   B H    1 
ATOM   1491 H HA   . ASN   A 1 92  ? 15.10420  10.51860  28.39468  1.000 17.71807 ? 570 ASN   B HA   1 
ATOM   1492 H HB2  . ASN   A 1 92  ? 17.01175  11.39109  26.49445  1.000 18.33438 ? 570 ASN   B HB2  1 
ATOM   1493 H HB3  . ASN   A 1 92  ? 15.97688  12.38917  27.17142  1.000 18.33438 ? 570 ASN   B HB3  1 
ATOM   1494 H HD21 . ASN   A 1 92  ? 19.03623  12.87630  28.78052  1.000 20.53352 ? 570 ASN   B HD21 1 
ATOM   1495 H HD22 . ASN   A 1 92  ? 18.49869  13.09039  27.40793  1.000 20.53352 ? 570 ASN   B HD22 1 
ATOM   1496 N N    . GLN   A 1 93  ? 14.74683  9.87632   25.27592  1.000 15.98065 ? 571 GLN   B N    1 
ATOM   1497 C CA   . GLN   A 1 93  ? 13.87152  9.97877   24.11694  1.000 18.62669 ? 571 GLN   B CA   1 
ATOM   1498 C C    . GLN   A 1 93  ? 12.89703  8.82925   24.02884  1.000 18.16614 ? 571 GLN   B C    1 
ATOM   1499 O O    . GLN   A 1 93  ? 11.73621  9.01778   23.62502  1.000 18.90560 ? 571 GLN   B O    1 
ATOM   1500 C CB   . GLN   A 1 93  ? 14.69234  10.00076  22.82915  1.000 22.96868 ? 571 GLN   B CB   1 
ATOM   1501 C CG   . GLN   A 1 93  ? 15.61719  11.19867  22.69711  1.000 30.20638 ? 571 GLN   B CG   1 
ATOM   1502 C CD   . GLN   A 1 93  ? 14.87077  12.47546  22.38121  1.000 37.67061 ? 571 GLN   B CD   1 
ATOM   1503 O OE1  . GLN   A 1 93  ? 13.75990  12.45325  21.83326  1.000 33.12792 ? 571 GLN   B OE1  1 
ATOM   1504 N NE2  . GLN   A 1 93  ? 15.47089  13.60091  22.73708  1.000 40.33837 ? 571 GLN   B NE2  1 
ATOM   1505 H H    . GLN   A 1 93  ? 15.46962  9.43551   25.12471  1.000 19.13079 ? 571 GLN   B H    1 
ATOM   1506 H HA   . GLN   A 1 93  ? 13.37795  10.81046  24.19155  1.000 22.30604 ? 571 GLN   B HA   1 
ATOM   1507 H HB2  . GLN   A 1 93  ? 15.24084  9.20134   22.79791  1.000 27.51643 ? 571 GLN   B HB2  1 
ATOM   1508 H HB3  . GLN   A 1 93  ? 14.08351  10.01509  22.07415  1.000 27.51643 ? 571 GLN   B HB3  1 
ATOM   1509 H HG2  . GLN   A 1 93  ? 16.09149  11.32657  23.53352  1.000 36.20167 ? 571 GLN   B HG2  1 
ATOM   1510 H HG3  . GLN   A 1 93  ? 16.24865  11.03394  21.97947  1.000 36.20167 ? 571 GLN   B HG3  1 
ATOM   1511 H HE21 . GLN   A 1 93  ? 16.23894  13.57522  23.12313  1.000 48.36006 ? 571 GLN   B HE21 1 
ATOM   1512 H HE22 . GLN   A 1 93  ? 15.09259  14.35754  22.58216  1.000 48.36006 ? 571 GLN   B HE22 1 
ATOM   1513 N N    . HIS   A 1 94  ? 13.34758  7.63947   24.43402  1.000 17.49048 ? 572 HIS   B N    1 
ATOM   1514 C CA   . HIS   A 1 94  ? 12.60550  6.41665   24.14227  1.000 18.20109 ? 572 HIS   B CA   1 
ATOM   1515 C C    . HIS   A 1 94  ? 12.29859  5.56164   25.35011  1.000 18.10191 ? 572 HIS   B C    1 
ATOM   1516 O O    . HIS   A 1 94  ? 11.61235  4.52940   25.20811  1.000 19.94909 ? 572 HIS   B O    1 
ATOM   1517 C CB   . HIS   A 1 94  ? 13.39344  5.56878   23.11906  1.000 18.82149 ? 572 HIS   B CB   1 
ATOM   1518 C CG   . HIS   A 1 94  ? 13.59790  6.24354   21.80115  1.000 21.45000 ? 572 HIS   B CG   1 
ATOM   1519 N ND1  . HIS   A 1 94  ? 12.54949  6.66083   21.00696  1.000 27.64549 ? 572 HIS   B ND1  1 
ATOM   1520 C CD2  . HIS   A 1 94  ? 14.72367  6.60613   21.15113  1.000 25.40217 ? 572 HIS   B CD2  1 
ATOM   1521 C CE1  . HIS   A 1 94  ? 13.02297  7.23346   19.91450  1.000 25.20106 ? 572 HIS   B CE1  1 
ATOM   1522 N NE2  . HIS   A 1 94  ? 14.33624  7.21211   19.97544  1.000 24.48640 ? 572 HIS   B NE2  1 
ATOM   1523 H H    . HIS   A 1 94  ? 14.07525  7.51794   24.87597  1.000 20.94259 ? 572 HIS   B H    1 
ATOM   1524 H HA   . HIS   A 1 94  ? 11.75173  6.66789   23.75646  1.000 21.79532 ? 572 HIS   B HA   1 
ATOM   1525 H HB2  . HIS   A 1 94  ? 14.26832  5.36995   23.48779  1.000 22.53980 ? 572 HIS   B HB2  1 
ATOM   1526 H HB3  . HIS   A 1 94  ? 12.90687  4.74547   22.95685  1.000 22.53980 ? 572 HIS   B HB3  1 
ATOM   1527 H HD2  . HIS   A 1 94  ? 15.59684  6.47226   21.44190  1.000 30.43662 ? 572 HIS   B HD2  1 
ATOM   1528 H HE1  . HIS   A 1 94  ? 12.51502  7.59010   19.22190  1.000 30.19528 ? 572 HIS   B HE1  1 
ATOM   1529 H HE2  . HIS   A 1 94  ? 14.86841  7.52609   19.37727  1.000 29.33770 ? 572 HIS   B HE2  1 
ATOM   1530 N N    . GLY   A 1 95  ? 12.78558  5.92552   26.50381  1.000 17.95307 ? 573 GLY   B N    1 
ATOM   1531 C CA   . GLY   A 1 95  ? 12.45226  5.21596   27.71968  1.000 17.17563 ? 573 GLY   B CA   1 
ATOM   1532 C C    . GLY   A 1 95  ? 13.30847  3.96820   27.90349  1.000 19.85557 ? 573 GLY   B C    1 
ATOM   1533 O O    . GLY   A 1 95  ? 14.40534  3.85919   27.39882  1.000 18.44491 ? 573 GLY   B O    1 
ATOM   1534 H H    . GLY   A 1 95  ? 13.32015  6.58919   26.61945  1.000 21.49770 ? 573 GLY   B H    1 
ATOM   1535 H HA2  . GLY   A 1 95  ? 12.59088  5.79921   28.48224  1.000 20.56477 ? 573 GLY   B HA2  1 
ATOM   1536 H HA3  . GLY   A 1 95  ? 11.52035  4.94823   27.69214  1.000 20.56477 ? 573 GLY   B HA3  1 
ATOM   1537 N N    . PHE   A 1 96  ? 12.76986  3.02452   28.65348  1.000 21.15869 ? 574 PHE   B N    1 
ATOM   1538 C CA   . PHE   A 1 96  ? 13.52056  1.86639   29.10115  1.000 19.85211 ? 574 PHE   B CA   1 
ATOM   1539 C C    . PHE   A 1 96  ? 13.15135  0.65955   28.26063  1.000 20.92172 ? 574 PHE   B C    1 
ATOM   1540 O O    . PHE   A 1 96  ? 11.97372  0.28809   28.18873  1.000 24.66989 ? 574 PHE   B O    1 
ATOM   1541 C CB   . PHE   A 1 96  ? 13.24933  1.60843   30.58220  1.000 19.61760 ? 574 PHE   B CB   1 
ATOM   1542 C CG   . PHE   A 1 96  ? 13.65916  2.75199   31.45491  1.000 18.88571 ? 574 PHE   B CG   1 
ATOM   1543 C CD1  . PHE   A 1 96  ? 14.98379  2.92300   31.81582  1.000 18.75581 ? 574 PHE   B CD1  1 
ATOM   1544 C CD2  . PHE   A 1 96  ? 12.71813  3.66433   31.88213  1.000 16.79876 ? 574 PHE   B CD2  1 
ATOM   1545 C CE1  . PHE   A 1 96  ? 15.36337  3.98652   32.61254  1.000 18.08720 ? 574 PHE   B CE1  1 
ATOM   1546 C CE2  . PHE   A 1 96  ? 13.10706  4.71640   32.68270  1.000 18.04841 ? 574 PHE   B CE2  1 
ATOM   1547 C CZ   . PHE   A 1 96  ? 14.40389  4.88354   33.01310  1.000 16.09451 ? 574 PHE   B CZ   1 
ATOM   1548 H H    . PHE   A 1 96  ? 11.95296  3.03255   28.92221  1.000 25.34444 ? 574 PHE   B H    1 
ATOM   1549 H HA   . PHE   A 1 96  ? 14.46980  2.02422   28.97894  1.000 23.77655 ? 574 PHE   B HA   1 
ATOM   1550 H HB2  . PHE   A 1 96  ? 12.29890  1.46077   30.70783  1.000 23.49513 ? 574 PHE   B HB2  1 
ATOM   1551 H HB3  . PHE   A 1 96  ? 13.74677  0.82414   30.86210  1.000 23.49513 ? 574 PHE   B HB3  1 
ATOM   1552 H HD1  . PHE   A 1 96  ? 15.62422  2.31711   31.51975  1.000 22.46098 ? 574 PHE   B HD1  1 
ATOM   1553 H HD2  . PHE   A 1 96  ? 11.82735  3.57049   31.63190  1.000 20.11252 ? 574 PHE   B HD2  1 
ATOM   1554 H HE1  . PHE   A 1 96  ? 16.25014  4.09249   32.87200  1.000 21.65865 ? 574 PHE   B HE1  1 
ATOM   1555 H HE2  . PHE   A 1 96  ? 12.46994  5.31616   32.99777  1.000 21.61210 ? 574 PHE   B HE2  1 
ATOM   1556 H HZ   . PHE   A 1 96  ? 14.65324  5.62078   33.52222  1.000 19.26742 ? 574 PHE   B HZ   1 
ATOM   1557 N N    . ASN   A 1 97  ? 14.15006  0.08762   27.60365  1.000 19.51428 ? 575 ASN   B N    1 
ATOM   1558 C CA   . ASN   A 1 97  ? 13.94786  -1.00926  26.65961  1.000 18.28497 ? 575 ASN   B CA   1 
ATOM   1559 C C    . ASN   A 1 97  ? 14.51275  -2.28044  27.28345  1.000 19.19750 ? 575 ASN   B C    1 
ATOM   1560 O O    . ASN   A 1 97  ? 15.73494  -2.41665  27.42661  1.000 19.52469 ? 575 ASN   B O    1 
ATOM   1561 C CB   . ASN   A 1 97  ? 14.63024  -0.71156  25.34146  1.000 18.84032 ? 575 ASN   B CB   1 
ATOM   1562 C CG   . ASN   A 1 97  ? 14.23769  -1.67533  24.25896  1.000 19.31150 ? 575 ASN   B CG   1 
ATOM   1563 O OD1  . ASN   A 1 97  ? 13.93555  -2.85202  24.54164  1.000 18.78515 ? 575 ASN   B OD1  1 
ATOM   1564 N ND2  . ASN   A 1 97  ? 14.25836  -1.21314  23.01600  1.000 19.10202 ? 575 ASN   B ND2  1 
ATOM   1565 H H    . ASN   A 1 97  ? 14.97347  0.32100   27.68809  1.000 23.37115 ? 575 ASN   B H    1 
ATOM   1566 H HA   . ASN   A 1 97  ? 12.99887  -1.13169  26.50046  1.000 21.89598 ? 575 ASN   B HA   1 
ATOM   1567 H HB2  . ASN   A 1 97  ? 14.38533  0.18141   25.05246  1.000 22.56240 ? 575 ASN   B HB2  1 
ATOM   1568 H HB3  . ASN   A 1 97  ? 15.59099  -0.76948  25.46185  1.000 22.56240 ? 575 ASN   B HB3  1 
ATOM   1569 H HD21 . ASN   A 1 97  ? 14.04149  -1.72796  22.36215  1.000 22.87644 ? 575 ASN   B HD21 1 
ATOM   1570 H HD22 . ASN   A 1 97  ? 14.48865  -0.39863  22.86389  1.000 22.87644 ? 575 ASN   B HD22 1 
ATOM   1571 N N    . ARG   A 1 98  ? 13.62586  -3.22745  27.60864  1.000 18.70941 ? 576 ARG   B N    1 
ATOM   1572 C CA   . ARG   A 1 98  ? 14.06907  -4.47151  28.22604  1.000 18.49873 ? 576 ARG   B CA   1 
ATOM   1573 C C    . ARG   A 1 98  ? 15.06889  -5.21603  27.35652  1.000 17.81366 ? 576 ARG   B C    1 
ATOM   1574 O O    . ARG   A 1 98  ? 15.86227  -6.00117  27.87051  1.000 17.77541 ? 576 ARG   B O    1 
ATOM   1575 C CB   . ARG   A 1 98  ? 12.87378  -5.37099  28.52259  1.000 14.52732 ? 576 ARG   B CB   1 
ATOM   1576 C CG   . ARG   A 1 98  ? 12.13652  -5.83063  27.29476  1.000 14.88619 ? 576 ARG   B CG   1 
ATOM   1577 C CD   . ARG   A 1 98  ? 10.80152  -6.47609  27.70258  1.000 16.19972 ? 576 ARG   B CD   1 
ATOM   1578 N NE   . ARG   A 1 98  ? 9.99054   -6.91859  26.57508  1.000 16.97714 ? 576 ARG   B NE   1 
ATOM   1579 C CZ   . ARG   A 1 98  ? 9.04606   -6.17885  26.00252  1.000 17.53157 ? 576 ARG   B CZ   1 
ATOM   1580 N NH1  . ARG   A 1 98  ? 8.88227   -4.89476  26.31083  1.000 17.87749 ? 576 ARG   B NH1  1 
ATOM   1581 N NH2  . ARG   A 1 98  ? 8.25328   -6.73491  25.08605  1.000 16.38891 ? 576 ARG   B NH2  1 
ATOM   1582 H H    . ARG   A 1 98  ? 12.77691  -3.17183  27.48297  1.000 22.40531 ? 576 ARG   B H    1 
ATOM   1583 H HA   . ARG   A 1 98  ? 14.50324  -4.25221  29.06527  1.000 22.15249 ? 576 ARG   B HA   1 
ATOM   1584 H HB2  . ARG   A 1 98  ? 13.18705  -6.16008  28.99174  1.000 17.38680 ? 576 ARG   B HB2  1 
ATOM   1585 H HB3  . ARG   A 1 98  ? 12.24662  -4.88196  29.07796  1.000 17.38680 ? 576 ARG   B HB3  1 
ATOM   1586 H HG2  . ARG   A 1 98  ? 11.95356  -5.07196  26.71869  1.000 17.81745 ? 576 ARG   B HG2  1 
ATOM   1587 H HG3  . ARG   A 1 98  ? 12.66870  -6.48755  26.81921  1.000 17.81745 ? 576 ARG   B HG3  1 
ATOM   1588 H HD2  . ARG   A 1 98  ? 10.98604  -7.25152  28.25536  1.000 19.39368 ? 576 ARG   B HD2  1 
ATOM   1589 H HD3  . ARG   A 1 98  ? 10.28179  -5.82789  28.20319  1.000 19.39368 ? 576 ARG   B HD3  1 
ATOM   1590 H HE   . ARG   A 1 98  ? 10.13177  -7.70663  26.26100  1.000 20.32658 ? 576 ARG   B HE   1 
ATOM   1591 H HH11 . ARG   A 1 98  ? 9.39443   -4.52375  26.89363  1.000 21.40701 ? 576 ARG   B HH11 1 
ATOM   1592 H HH12 . ARG   A 1 98  ? 8.26425   -4.43589  25.92730  1.000 21.40701 ? 576 ARG   B HH12 1 
ATOM   1593 H HH21 . ARG   A 1 98  ? 8.35669   -7.56156  24.87261  1.000 19.62071 ? 576 ARG   B HH21 1 
ATOM   1594 H HH22 . ARG   A 1 98  ? 7.63851   -6.26694  24.70835  1.000 19.62071 ? 576 ARG   B HH22 1 
ATOM   1595 N N    . SER   A 1 99  ? 15.04595  -4.99206  26.05005  1.000 16.43121 ? 577 SER   B N    1 
ATOM   1596 C CA   . SER   A 1 99  ? 15.93327  -5.72371  25.15987  1.000 19.91290 ? 577 SER   B CA   1 
ATOM   1597 C C    . SER   A 1 99  ? 17.38343  -5.27606  25.34157  1.000 21.31443 ? 577 SER   B C    1 
ATOM   1598 O O    . SER   A 1 99  ? 18.28980  -5.97948  24.89640  1.000 22.59365 ? 577 SER   B O    1 
ATOM   1599 C CB   . SER   A 1 99  ? 15.50133  -5.53408  23.71430  1.000 24.05395 ? 577 SER   B CB   1 
ATOM   1600 O OG   . SER   A 1 99  ? 14.22814  -6.11889  23.50413  1.000 22.44386 ? 577 SER   B OG   1 
ATOM   1601 H H    . SER   A 1 99  ? 14.53061  -4.42677  25.65703  1.000 19.67147 ? 577 SER   B H    1 
ATOM   1602 H HA   . SER   A 1 99  ? 15.87640  -6.67253  25.35325  1.000 23.84950 ? 577 SER   B HA   1 
ATOM   1603 H HB2  . SER   A 1 99  ? 15.45221  -4.58533  23.51846  1.000 28.81875 ? 577 SER   B HB2  1 
ATOM   1604 H HB3  . SER   A 1 99  ? 16.14789  -5.96036  23.13022  1.000 28.81875 ? 577 SER   B HB3  1 
ATOM   1605 H HG   . SER   A 1 99  ? 14.04082  -6.11281  22.68530  1.000 26.88665 ? 577 SER   B HG   1 
ATOM   1606 N N    . CYS   A 1 100 ? 17.59166  -4.13718  25.99205  1.000 19.33187 ? 578 CYS   B N    1 
ATOM   1607 C CA   . CYS   A 1 100 ? 18.90776  -3.56354  26.22339  1.000 24.02799 ? 578 CYS   B CA   1 
ATOM   1608 C C    . CYS   A 1 100 ? 19.35085  -3.72395  27.66653  1.000 25.56017 ? 578 CYS   B C    1 
ATOM   1609 O O    . CYS   A 1 100 ? 20.45827  -3.31586  28.00385  1.000 25.06664 ? 578 CYS   B O    1 
ATOM   1610 C CB   . CYS   A 1 100 ? 18.91008  -2.05881  25.86041  1.000 24.61792 ? 578 CYS   B CB   1 
ATOM   1611 S SG   . CYS   A 1 100 ? 18.38685  -1.73632  24.16191  1.000 34.63917 ? 578 CYS   B SG   1 
ATOM   1612 H H    . CYS   A 1 100 ? 16.95793  -3.65890  26.32256  1.000 23.15226 ? 578 CYS   B H    1 
ATOM   1613 H HA   . CYS   A 1 100 ? 19.54835  -4.00873  25.64689  1.000 28.78760 ? 578 CYS   B HA   1 
ATOM   1614 H HB2  . CYS   A 1 100 ? 18.30167  -1.59170  26.45416  1.000 29.49552 ? 578 CYS   B HB2  1 
ATOM   1615 H HB3  . CYS   A 1 100 ? 19.80952  -1.71158  25.96689  1.000 29.49552 ? 578 CYS   B HB3  1 
ATOM   1616 H HG   . CYS   A 1 100 ? 18.41166  -0.55310  23.96345  1.000 41.52102 ? 578 CYS   B HG   1 
ATOM   1617 N N    . ALA   A 1 101 ? 18.50794  -4.28314  28.52551  1.000 22.28563 ? 579 ALA   B N    1 
ATOM   1618 C CA   . ALA   A 1 101 ? 18.80679  -4.34302  29.94583  1.000 22.40335 ? 579 ALA   B CA   1 
ATOM   1619 C C    . ALA   A 1 101 ? 19.95379  -5.30575  30.20734  1.000 26.43180 ? 579 ALA   B C    1 
ATOM   1620 O O    . ALA   A 1 101 ? 20.07729  -6.33507  29.54758  1.000 28.21566 ? 579 ALA   B O    1 
ATOM   1621 C CB   . ALA   A 1 101 ? 17.56615  -4.79726  30.72617  1.000 21.32537 ? 579 ALA   B CB   1 
ATOM   1622 H H    . ALA   A 1 101 ? 17.75402  -4.63598  28.30938  1.000 26.69677 ? 579 ALA   B H    1 
ATOM   1623 H HA   . ALA   A 1 101 ? 19.06510  -3.46184  30.25840  1.000 26.83804 ? 579 ALA   B HA   1 
ATOM   1624 H HB1  . ALA   A 1 101 ? 17.78132  -4.82767  31.67152  1.000 25.54446 ? 579 ALA   B HB1  1 
ATOM   1625 H HB2  . ALA   A 1 101 ? 16.84660  -4.16557  30.57086  1.000 25.54446 ? 579 ALA   B HB2  1 
ATOM   1626 H HB3  . ALA   A 1 101 ? 17.30453  -5.67899  30.41794  1.000 25.54446 ? 579 ALA   B HB3  1 
ATOM   1627 N N    . GLY   A 1 102 ? 20.77206  -4.97779  31.19111  1.000 31.75860 ? 580 GLY   B N    1 
ATOM   1628 C CA   . GLY   A 1 102 ? 21.81365  -5.89080  31.60936  1.000 33.47204 ? 580 GLY   B CA   1 
ATOM   1629 C C    . GLY   A 1 102 ? 21.27482  -6.94471  32.55569  1.000 28.93138 ? 580 GLY   B C    1 
ATOM   1630 O O    . GLY   A 1 102 ? 20.22735  -6.78023  33.16499  1.000 27.07596 ? 580 GLY   B O    1 
ATOM   1631 H H    . GLY   A 1 102 ? 20.74483  -4.23806  31.62891  1.000 38.06433 ? 580 GLY   B H    1 
ATOM   1632 H HA2  . GLY   A 1 102 ? 22.18881  -6.33402  30.83237  1.000 40.12046 ? 580 GLY   B HA2  1 
ATOM   1633 H HA3  . GLY   A 1 102 ? 22.51603  -5.39768  32.06146  1.000 40.12046 ? 580 GLY   B HA3  1 
ATOM   1634 N N    . LYS   A 1 103 ? 21.98833  -8.05750  32.65121  1.000 26.92781 ? 581 LYS   B N    1 
ATOM   1635 C CA   . LYS   A 1 103 ? 21.62692  -9.07311  33.62570  1.000 26.03912 ? 581 LYS   B CA   1 
ATOM   1636 C C    . LYS   A 1 103 ? 21.97504  -8.54153  35.01249  1.000 25.66303 ? 581 LYS   B C    1 
ATOM   1637 O O    . LYS   A 1 103 ? 23.10437  -8.07179  35.24771  1.000 23.57346 ? 581 LYS   B O    1 
ATOM   1638 C CB   . LYS   A 1 103 ? 22.35950  -10.38933 33.34213  1.000 27.09344 ? 581 LYS   B CB   1 
ATOM   1639 C CG   . LYS   A 1 103 ? 21.81670  -11.56560 34.17905  1.000 29.85095 ? 581 LYS   B CG   1 
ATOM   1640 C CD   . LYS   A 1 103 ? 22.37707  -12.90291 33.70052  1.000 40.05604 ? 581 LYS   B CD   1 
ATOM   1641 C CE   . LYS   A 1 103 ? 21.86449  -14.07759 34.55729  1.000 35.85199 ? 581 LYS   B CE   1 
ATOM   1642 N NZ   . LYS   A 1 103 ? 20.46740  -14.56587 34.18277  1.000 28.70187 ? 581 LYS   B NZ   1 
ATOM   1643 H H    . LYS   A 1 103 ? 22.67609  -8.24557  32.17037  1.000 32.26739 ? 581 LYS   B H    1 
ATOM   1644 H HA   . LYS   A 1 103 ? 20.67805  -9.26922  33.57995  1.000 31.20096 ? 581 LYS   B HA   1 
ATOM   1645 H HB2  . LYS   A 1 103 ? 22.25394  -10.61379 32.40438  1.000 32.46614 ? 581 LYS   B HB2  1 
ATOM   1646 H HB3  . LYS   A 1 103 ? 23.29985  -10.27914 33.55307  1.000 32.46614 ? 581 LYS   B HB3  1 
ATOM   1647 H HG2  . LYS   A 1 103 ? 22.07144  -11.44351 35.10700  1.000 35.77516 ? 581 LYS   B HG2  1 
ATOM   1648 H HG3  . LYS   A 1 103 ? 20.85026  -11.59541 34.10149  1.000 35.77516 ? 581 LYS   B HG3  1 
ATOM   1649 H HD2  . LYS   A 1 103 ? 22.10339  -13.05466 32.78238  1.000 48.02126 ? 581 LYS   B HD2  1 
ATOM   1650 H HD3  . LYS   A 1 103 ? 23.34510  -12.88393 33.75933  1.000 48.02126 ? 581 LYS   B HD3  1 
ATOM   1651 H HE2  . LYS   A 1 103 ? 22.47363  -14.82548 34.45474  1.000 42.97641 ? 581 LYS   B HE2  1 
ATOM   1652 H HE3  . LYS   A 1 103 ? 21.83770  -13.79637 35.48525  1.000 42.97641 ? 581 LYS   B HE3  1 
ATOM   1653 H HZ1  . LYS   A 1 103 ? 20.22785  -15.23912 34.71329  1.000 34.39625 ? 581 LYS   B HZ1  1 
ATOM   1654 H HZ2  . LYS   A 1 103 ? 19.87932  -13.90392 34.27272  1.000 34.39625 ? 581 LYS   B HZ2  1 
ATOM   1655 H HZ3  . LYS   A 1 103 ? 20.45930  -14.84664 33.33826  1.000 34.39625 ? 581 LYS   B HZ3  1 
ATOM   1656 N N    . ASN   A 1 104 ? 20.99888  -8.58064  35.93291  1.000 21.43019 ? 582 ASN   B N    1 
ATOM   1657 C CA   . ASN   A 1 104 ? 21.24621  -8.08285  37.27231  1.000 21.77188 ? 582 ASN   B CA   1 
ATOM   1658 C C    . ASN   A 1 104 ? 22.04153  -9.11725  38.04442  1.000 19.61824 ? 582 ASN   B C    1 
ATOM   1659 O O    . ASN   A 1 104 ? 21.89530  -10.31758 37.81672  1.000 18.03823 ? 582 ASN   B O    1 
ATOM   1660 C CB   . ASN   A 1 104 ? 19.91802  -7.77693  37.97704  1.000 17.99956 ? 582 ASN   B CB   1 
ATOM   1661 C CG   . ASN   A 1 104 ? 20.10194  -6.89549  39.17518  1.000 22.11353 ? 582 ASN   B CG   1 
ATOM   1662 O OD1  . ASN   A 1 104 ? 20.62498  -5.78261  39.04189  1.000 21.43750 ? 582 ASN   B OD1  1 
ATOM   1663 N ND2  . ASN   A 1 104 ? 19.70134  -7.36644  40.35550  1.000 20.40608 ? 582 ASN   B ND2  1 
ATOM   1664 H H    . ASN   A 1 104 ? 20.20610  -8.88586  35.79894  1.000 25.67024 ? 582 ASN   B H    1 
ATOM   1665 H HA   . ASN   A 1 104 ? 21.75441  -7.25697  37.24873  1.000 26.08027 ? 582 ASN   B HA   1 
ATOM   1666 H HB2  . ASN   A 1 104 ? 19.32566  -7.32395  37.35670  1.000 21.55348 ? 582 ASN   B HB2  1 
ATOM   1667 H HB3  . ASN   A 1 104 ? 19.51574  -8.60862  38.27261  1.000 21.55348 ? 582 ASN   B HB3  1 
ATOM   1668 H HD21 . ASN   A 1 104 ? 19.79229  -6.88649  41.06329  1.000 24.44131 ? 582 ASN   B HD21 1 
ATOM   1669 H HD22 . ASN   A 1 104 ? 19.35183  -8.15036  40.40952  1.000 24.44131 ? 582 ASN   B HD22 1 
ATOM   1670 N N    . ALA   A 1 105 ? 22.84636  -8.64241  38.99963  1.000 20.65077 ? 583 ALA   B N    1 
ATOM   1671 C CA   . ALA   A 1 105 ? 23.66158  -9.58325  39.78121  1.000 19.83487 ? 583 ALA   B CA   1 
ATOM   1672 C C    . ALA   A 1 105 ? 22.80553  -10.54788 40.58999  1.000 17.80462 ? 583 ALA   B C    1 
ATOM   1673 O O    . ALA   A 1 105 ? 23.23529  -11.68140 40.90235  1.000 16.38196 ? 583 ALA   B O    1 
ATOM   1674 C CB   . ALA   A 1 105 ? 24.61172  -8.85456  40.72153  1.000 18.71462 ? 583 ALA   B CB   1 
ATOM   1675 H H    . ALA   A 1 105 ? 22.93729  -7.81325  39.20898  1.000 24.73494 ? 583 ALA   B H    1 
ATOM   1676 H HA   . ALA   A 1 105 ? 24.19484  -10.08783 39.14722  1.000 23.75586 ? 583 ALA   B HA   1 
ATOM   1677 H HB1  . ALA   A 1 105 ? 25.12919  -9.50863  41.21683  1.000 22.41156 ? 583 ALA   B HB1  1 
ATOM   1678 H HB2  . ALA   A 1 105 ? 25.20375  -8.29171  40.19847  1.000 22.41156 ? 583 ALA   B HB2  1 
ATOM   1679 H HB3  . ALA   A 1 105 ? 24.09346  -8.30990  41.33444  1.000 22.41156 ? 583 ALA   B HB3  1 
ATOM   1680 N N    . VAL   A 1 106 ? 21.60452  -10.13446 40.96513  1.000 15.97734 ? 584 VAL   B N    1 
ATOM   1681 C CA   . VAL   A 1 106 ? 20.58093  -11.08410 41.44087  1.000 15.87150 ? 584 VAL   B CA   1 
ATOM   1682 C C    . VAL   A 1 106 ? 19.37349  -10.92032 40.50727  1.000 15.81671 ? 584 VAL   B C    1 
ATOM   1683 O O    . VAL   A 1 106 ? 18.70113  -9.88316  40.52775  1.000 15.83699 ? 584 VAL   B O    1 
ATOM   1684 C CB   . VAL   A 1 106 ? 20.19413  -10.84105 42.90276  1.000 18.53683 ? 584 VAL   B CB   1 
ATOM   1685 C CG1  . VAL   A 1 106 ? 19.25256  -11.97180 43.39451  1.000 17.63411 ? 584 VAL   B CG1  1 
ATOM   1686 C CG2  . VAL   A 1 106 ? 21.39362  -10.78558 43.79663  1.000 20.83830 ? 584 VAL   B CG2  1 
ATOM   1687 H H    . VAL   A 1 106 ? 21.35013  -9.31299  40.95664  1.000 19.12682 ? 584 VAL   B H    1 
ATOM   1688 H HA   . VAL   A 1 106 ? 20.91426  -11.99244 41.37223  1.000 18.99982 ? 584 VAL   B HA   1 
ATOM   1689 H HB   . VAL   A 1 106 ? 19.74252  -9.98389  42.94999  1.000 22.19821 ? 584 VAL   B HB   1 
ATOM   1690 H HG11 . VAL   A 1 106 ? 18.95522  -11.76608 44.29460  1.000 21.11495 ? 584 VAL   B HG11 1 
ATOM   1691 H HG12 . VAL   A 1 106 ? 18.48913  -12.02846 42.79880  1.000 21.11495 ? 584 VAL   B HG12 1 
ATOM   1692 H HG13 . VAL   A 1 106 ? 19.73834  -12.81138 43.39041  1.000 21.11495 ? 584 VAL   B HG13 1 
ATOM   1693 H HG21 . VAL   A 1 106 ? 21.09796  -10.72562 44.71852  1.000 24.95997 ? 584 VAL   B HG21 1 
ATOM   1694 H HG22 . VAL   A 1 106 ? 21.91960  -11.59063 43.66963  1.000 24.95997 ? 584 VAL   B HG22 1 
ATOM   1695 H HG23 . VAL   A 1 106 ? 21.92244  -10.00537 43.56744  1.000 24.95997 ? 584 VAL   B HG23 1 
ATOM   1696 N N    . SER   A 1 107 ? 19.16757  -11.88579 39.62732  1.000 13.60526 ? 585 SER   B N    1 
ATOM   1697 C CA   . SER   A 1 107 ? 18.14398  -11.78299 38.62270  1.000 14.27932 ? 585 SER   B CA   1 
ATOM   1698 C C    . SER   A 1 107 ? 16.83508  -12.35064 39.11108  1.000 15.29208 ? 585 SER   B C    1 
ATOM   1699 O O    . SER   A 1 107 ? 16.76070  -13.52862 39.50625  1.000 14.26540 ? 585 SER   B O    1 
ATOM   1700 C CB   . SER   A 1 107 ? 18.53040  -12.46802 37.32024  1.000 16.88013 ? 585 SER   B CB   1 
ATOM   1701 O OG   . SER   A 1 107 ? 17.45857  -12.22944 36.41426  1.000 16.23955 ? 585 SER   B OG   1 
ATOM   1702 H H    . SER   A 1 107 ? 19.61772  -12.61794 39.59696  1.000 16.28033 ? 585 SER   B H    1 
ATOM   1703 H HA   . SER   A 1 107 ? 18.02681  -10.83683 38.44397  1.000 17.08920 ? 585 SER   B HA   1 
ATOM   1704 H HB2  . SER   A 1 107 ? 19.35233  -12.08723 36.97334  1.000 20.21017 ? 585 SER   B HB2  1 
ATOM   1705 H HB3  . SER   A 1 107 ? 18.64093  -13.42096 37.46375  1.000 20.21017 ? 585 SER   B HB3  1 
ATOM   1706 H HG   . SER   A 1 107 ? 17.62695  -12.58217 35.67074  1.000 19.44147 ? 585 SER   B HG   1 
ATOM   1707 N N    . TYR   A 1 108 ? 15.78449  -11.52792 39.00785  1.000 11.97626 ? 586 TYR   B N    1 
ATOM   1708 C CA   . TYR   A 1 108 ? 14.40482  -11.94990 39.25016  1.000 15.11742 ? 586 TYR   B CA   1 
ATOM   1709 C C    . TYR   A 1 108 ? 13.59910  -11.91323 37.96851  1.000 13.99455 ? 586 TYR   B C    1 
ATOM   1710 O O    . TYR   A 1 108 ? 12.37785  -11.88987 38.01301  1.000 15.15151 ? 586 TYR   B O    1 
ATOM   1711 C CB   . TYR   A 1 108 ? 13.77735  -11.08641 40.34073  1.000 15.64857 ? 586 TYR   B CB   1 
ATOM   1712 C CG   . TYR   A 1 108 ? 14.42269  -11.32752 41.68034  1.000 14.97591 ? 586 TYR   B CG   1 
ATOM   1713 C CD1  . TYR   A 1 108 ? 14.01168  -12.39489 42.49570  1.000 16.19912 ? 586 TYR   B CD1  1 
ATOM   1714 C CD2  . TYR   A 1 108 ? 15.49284  -10.54337 42.11828  1.000 15.86885 ? 586 TYR   B CD2  1 
ATOM   1715 C CE1  . TYR   A 1 108 ? 14.63998  -12.64043 43.72219  1.000 18.98280 ? 586 TYR   B CE1  1 
ATOM   1716 C CE2  . TYR   A 1 108 ? 16.07571  -10.75347 43.33654  1.000 16.41778 ? 586 TYR   B CE2  1 
ATOM   1717 C CZ   . TYR   A 1 108 ? 15.65799  -11.82508 44.13030  1.000 17.06758 ? 586 TYR   B CZ   1 
ATOM   1718 O OH   . TYR   A 1 108 ? 16.24990  -12.05766 45.33828  1.000 19.69301 ? 586 TYR   B OH   1 
ATOM   1719 H H    . TYR   A 1 108 ? 15.85036  -10.69790 38.79259  1.000 14.32553 ? 586 TYR   B H    1 
ATOM   1720 H HA   . TYR   A 1 108 ? 14.38805  -12.86242 39.57870  1.000 18.09491 ? 586 TYR   B HA   1 
ATOM   1721 H HB2  . TYR   A 1 108 ? 13.88970  -10.15046 40.11207  1.000 18.73230 ? 586 TYR   B HB2  1 
ATOM   1722 H HB3  . TYR   A 1 108 ? 12.83380  -11.29908 40.41400  1.000 18.73230 ? 586 TYR   B HB3  1 
ATOM   1723 H HD1  . TYR   A 1 108 ? 13.31471  -12.94429 42.21771  1.000 19.39296 ? 586 TYR   B HD1  1 
ATOM   1724 H HD2  . TYR   A 1 108 ? 15.81503  -9.86487  41.56989  1.000 18.99663 ? 586 TYR   B HD2  1 
ATOM   1725 H HE1  . TYR   A 1 108 ? 14.36700  -13.35228 44.25477  1.000 22.73337 ? 586 TYR   B HE1  1 
ATOM   1726 H HE2  . TYR   A 1 108 ? 16.74809  -10.18517 43.63627  1.000 19.65534 ? 586 TYR   B HE2  1 
ATOM   1727 H HH   . TYR   A 1 108 ? 16.85498  -11.49140 45.47550  1.000 23.58563 ? 586 TYR   B HH   1 
ATOM   1728 N N    . GLY   A 1 109 ? 14.27218  -11.93189 36.82892  1.000 14.76447 ? 587 GLY   B N    1 
ATOM   1729 C CA   . GLY   A 1 109 ? 13.61363  -11.91570 35.53786  1.000 15.22468 ? 587 GLY   B CA   1 
ATOM   1730 C C    . GLY   A 1 109 ? 14.40744  -11.11549 34.53935  1.000 14.45591 ? 587 GLY   B C    1 
ATOM   1731 O O    . GLY   A 1 109 ? 15.24573  -10.29203 34.89458  1.000 16.19117 ? 587 GLY   B O    1 
ATOM   1732 H H    . GLY   A 1 109 ? 15.13041  -11.95447 36.77865  1.000 17.67138 ? 587 GLY   B H    1 
ATOM   1733 H HA2  . GLY   A 1 109 ? 13.52048  -12.82265 35.20671  1.000 18.22362 ? 587 GLY   B HA2  1 
ATOM   1734 H HA3  . GLY   A 1 109 ? 12.73263  -11.51925 35.62492  1.000 18.22362 ? 587 GLY   B HA3  1 
ATOM   1735 N N    . LYS   A 1 110 ? 14.11695  -11.35265 33.26705  1.000 15.17996 ? 588 LYS   B N    1 
ATOM   1736 C CA   . LYS   A 1 110 ? 14.75137  -10.68565 32.14071  1.000 16.48338 ? 588 LYS   B CA   1 
ATOM   1737 C C    . LYS   A 1 110 ? 13.88946  -9.48001  31.77389  1.000 17.43008 ? 588 LYS   B C    1 
ATOM   1738 O O    . LYS   A 1 110 ? 13.02176  -9.52219  30.91253  1.000 18.45961 ? 588 LYS   B O    1 
ATOM   1739 C CB   . LYS   A 1 110 ? 14.92090  -11.66018 30.98809  1.000 20.58590 ? 588 LYS   B CB   1 
ATOM   1740 C CG   . LYS   A 1 110 ? 15.70609  -12.90873 31.39675  1.000 24.13192 ? 588 LYS   B CG   1 
ATOM   1741 C CD   . LYS   A 1 110 ? 15.88993  -13.89651 30.23502  1.000 32.91859 ? 588 LYS   B CD   1 
ATOM   1742 C CE   . LYS   A 1 110 ? 16.61621  -15.15522 30.72020  1.000 30.87663 ? 588 LYS   B CE   1 
ATOM   1743 N NZ   . LYS   A 1 110 ? 16.84796  -16.15451 29.61275  1.000 40.58841 ? 588 LYS   B NZ   1 
ATOM   1744 H H    . LYS   A 1 110 ? 13.52536  -11.92503 33.01803  1.000 18.16997 ? 588 LYS   B H    1 
ATOM   1745 H HA   . LYS   A 1 110 ? 15.63232  -10.36392 32.38834  1.000 19.73407 ? 588 LYS   B HA   1 
ATOM   1746 H HB2  . LYS   A 1 110 ? 14.04572  -11.94100 30.67808  1.000 24.65709 ? 588 LYS   B HB2  1 
ATOM   1747 H HB3  . LYS   A 1 110 ? 15.40245  -11.22155 30.26934  1.000 24.65709 ? 588 LYS   B HB3  1 
ATOM   1748 H HG2  . LYS   A 1 110 ? 16.58588  -12.64273 31.70676  1.000 28.91232 ? 588 LYS   B HG2  1 
ATOM   1749 H HG3  . LYS   A 1 110 ? 15.22832  -13.36562 32.10659  1.000 28.91232 ? 588 LYS   B HG3  1 
ATOM   1750 H HD2  . LYS   A 1 110 ? 15.02251  -14.15411 29.88554  1.000 39.45632 ? 588 LYS   B HD2  1 
ATOM   1751 H HD3  . LYS   A 1 110 ? 16.41976  -13.48271 29.53578  1.000 39.45632 ? 588 LYS   B HD3  1 
ATOM   1752 H HE2  . LYS   A 1 110 ? 17.47983  -14.90291 31.08270  1.000 37.00597 ? 588 LYS   B HE2  1 
ATOM   1753 H HE3  . LYS   A 1 110 ? 16.08145  -15.58525 31.40576  1.000 37.00597 ? 588 LYS   B HE3  1 
ATOM   1754 H HZ1  . LYS   A 1 110 ? 17.27025  -16.87002 29.93184  1.000 48.66011 ? 588 LYS   B HZ1  1 
ATOM   1755 H HZ2  . LYS   A 1 110 ? 16.06940  -16.40974 29.26520  1.000 48.66011 ? 588 LYS   B HZ2  1 
ATOM   1756 H HZ3  . LYS   A 1 110 ? 17.34444  -15.78829 28.97127  1.000 48.66011 ? 588 LYS   B HZ3  1 
ATOM   1757 N N    . GLY   A 1 111 ? 14.12058  -8.39600  32.48404  1.000 15.19187 ? 589 GLY   B N    1 
ATOM   1758 C CA   . GLY   A 1 111 ? 13.40015  -7.17181  32.22464  1.000 15.83610 ? 589 GLY   B CA   1 
ATOM   1759 C C    . GLY   A 1 111 ? 14.18234  -5.97721  32.70754  1.000 16.57030 ? 589 GLY   B C    1 
ATOM   1760 O O    . GLY   A 1 111 ? 15.35208  -6.09447  33.07949  1.000 17.31373 ? 589 GLY   B O    1 
ATOM   1761 H H    . GLY   A 1 111 ? 14.69212  -8.34333  33.12449  1.000 18.18425 ? 589 GLY   B H    1 
ATOM   1762 H HA2  . GLY   A 1 111 ? 13.24512  -7.07871  31.27164  1.000 18.95734 ? 589 GLY   B HA2  1 
ATOM   1763 H HA3  . GLY   A 1 111 ? 12.54560  -7.19128  32.68318  1.000 18.95734 ? 589 GLY   B HA3  1 
ATOM   1764 N N    . THR   A 1 112 ? 13.50774  -4.81174  32.73138  1.000 13.56505 ? 590 THR   B N    1 
ATOM   1765 C CA   . THR   A 1 112 ? 14.15750  -3.59443  33.21856  1.000 14.77542 ? 590 THR   B CA   1 
ATOM   1766 C C    . THR   A 1 112 ? 14.00657  -3.51138  34.73193  1.000 15.34533 ? 590 THR   B C    1 
ATOM   1767 O O    . THR   A 1 112 ? 12.89001  -3.68475  35.25576  1.000 14.40725 ? 590 THR   B O    1 
ATOM   1768 C CB   . THR   A 1 112 ? 13.54158  -2.35868  32.55540  1.000 16.71887 ? 590 THR   B CB   1 
ATOM   1769 O OG1  . THR   A 1 112 ? 13.67189  -2.49624  31.12156  1.000 18.41549 ? 590 THR   B OG1  1 
ATOM   1770 C CG2  . THR   A 1 112 ? 14.29830  -1.11493  32.99520  1.000 20.17012 ? 590 THR   B CG2  1 
ATOM   1771 H H    . THR   A 1 112 ? 12.69301  -4.71037  32.47539  1.000 16.23208 ? 590 THR   B H    1 
ATOM   1772 H HA   . THR   A 1 112 ? 15.10288  -3.61683  33.00259  1.000 17.68452 ? 590 THR   B HA   1 
ATOM   1773 H HB   . THR   A 1 112 ? 12.60799  -2.26762  32.80242  1.000 20.01665 ? 590 THR   B HB   1 
ATOM   1774 H HG1  . THR   A 1 112 ? 13.34479  -1.82454  30.73759  1.000 22.05260 ? 590 THR   B HG1  1 
ATOM   1775 H HG21 . THR   A 1 112 ? 13.83827  -0.31949  32.68448  1.000 24.15815 ? 590 THR   B HG21 1 
ATOM   1776 H HG22 . THR   A 1 112 ? 14.35666  -1.08700  33.96304  1.000 24.15815 ? 590 THR   B HG22 1 
ATOM   1777 H HG23 . THR   A 1 112 ? 15.19520  -1.12436  32.62589  1.000 24.15815 ? 590 THR   B HG23 1 
ATOM   1778 N N    . TYR   A 1 113 ? 15.11390  -3.19709  35.41972  1.000 13.85520 ? 591 TYR   B N    1 
ATOM   1779 C CA   . TYR   A 1 113 ? 15.17830  -3.16672  36.87212  1.000 12.94103 ? 591 TYR   B CA   1 
ATOM   1780 C C    . TYR   A 1 113 ? 15.10045  -1.74375  37.41596  1.000 14.25568 ? 591 TYR   B C    1 
ATOM   1781 O O    . TYR   A 1 113 ? 15.72041  -0.81968  36.86411  1.000 13.71368 ? 591 TYR   B O    1 
ATOM   1782 C CB   . TYR   A 1 113 ? 16.47593  -3.80269  37.38301  1.000 15.16287 ? 591 TYR   B CB   1 
ATOM   1783 C CG   . TYR   A 1 113 ? 16.40962  -5.31544  37.37096  1.000 15.27713 ? 591 TYR   B CG   1 
ATOM   1784 C CD1  . TYR   A 1 113 ? 16.28818  -6.00304  36.17998  1.000 15.58378 ? 591 TYR   B CD1  1 
ATOM   1785 C CD2  . TYR   A 1 113 ? 16.48806  -6.02745  38.53608  1.000 13.44500 ? 591 TYR   B CD2  1 
ATOM   1786 C CE1  . TYR   A 1 113 ? 16.19948  -7.41203  36.17067  1.000 15.39996 ? 591 TYR   B CE1  1 
ATOM   1787 C CE2  . TYR   A 1 113 ? 16.42570  -7.42072  38.53333  1.000 16.12671 ? 591 TYR   B CE2  1 
ATOM   1788 C CZ   . TYR   A 1 113 ? 16.25917  -8.08878  37.35418  1.000 14.10688 ? 591 TYR   B CZ   1 
ATOM   1789 O OH   . TYR   A 1 113 ? 16.13799  -9.44111  37.36407  1.000 14.81118 ? 591 TYR   B OH   1 
ATOM   1790 H H    . TYR   A 1 113 ? 15.86126  -2.99214  35.04681  1.000 16.58026 ? 591 TYR   B H    1 
ATOM   1791 H HA   . TYR   A 1 113 ? 14.41432  -3.66300  37.20518  1.000 15.48325 ? 591 TYR   B HA   1 
ATOM   1792 H HB2  . TYR   A 1 113 ? 17.21150  -3.52662  36.81414  1.000 18.14945 ? 591 TYR   B HB2  1 
ATOM   1793 H HB3  . TYR   A 1 113 ? 16.63507  -3.51315  38.29501  1.000 18.14945 ? 591 TYR   B HB3  1 
ATOM   1794 H HD1  . TYR   A 1 113 ? 16.26460  -5.53419  35.37716  1.000 18.65455 ? 591 TYR   B HD1  1 
ATOM   1795 H HD2  . TYR   A 1 113 ? 16.58451  -5.57531  39.34303  1.000 16.08801 ? 591 TYR   B HD2  1 
ATOM   1796 H HE1  . TYR   A 1 113 ? 16.10169  -7.87277  35.36876  1.000 18.43397 ? 591 TYR   B HE1  1 
ATOM   1797 H HE2  . TYR   A 1 113 ? 16.49726  -7.89286  39.33137  1.000 19.30607 ? 591 TYR   B HE2  1 
ATOM   1798 H HH   . TYR   A 1 113 ? 16.02224  -9.72491  36.58198  1.000 17.72743 ? 591 TYR   B HH   1 
ATOM   1799 N N    . PHE   A 1 114 ? 14.36165  -1.58551  38.52132  1.000 12.12631 ? 592 PHE   B N    1 
ATOM   1800 C CA   . PHE   A 1 114 ? 14.21449  -0.30804  39.20330  1.000 13.79842 ? 592 PHE   B CA   1 
ATOM   1801 C C    . PHE   A 1 114 ? 14.40842  -0.52799  40.69996  1.000 14.45933 ? 592 PHE   B C    1 
ATOM   1802 O O    . PHE   A 1 114 ? 13.89075  -1.50024  41.26834  1.000 14.90800 ? 592 PHE   B O    1 
ATOM   1803 C CB   . PHE   A 1 114 ? 12.84626  0.30442   38.89580  1.000 14.14245 ? 592 PHE   B CB   1 
ATOM   1804 C CG   . PHE   A 1 114 ? 12.66136  0.60977   37.44610  1.000 12.74016 ? 592 PHE   B CG   1 
ATOM   1805 C CD1  . PHE   A 1 114 ? 13.13875  1.75257   36.89279  1.000 12.74127 ? 592 PHE   B CD1  1 
ATOM   1806 C CD2  . PHE   A 1 114 ? 12.07314  -0.31071  36.61401  1.000 14.83343 ? 592 PHE   B CD2  1 
ATOM   1807 C CE1  . PHE   A 1 114 ? 13.01255  2.01486   35.54293  1.000 14.17595 ? 592 PHE   B CE1  1 
ATOM   1808 C CE2  . PHE   A 1 114 ? 11.92254  -0.04245  35.24826  1.000 16.64658 ? 592 PHE   B CE2  1 
ATOM   1809 C CZ   . PHE   A 1 114 ? 12.39809  1.11884   34.72349  1.000 17.65084 ? 592 PHE   B CZ   1 
ATOM   1810 H H    . PHE   A 1 114 ? 13.92735  -2.22393  38.90000  1.000 14.50559 ? 592 PHE   B H    1 
ATOM   1811 H HA   . PHE   A 1 114 ? 14.89141  0.32483   38.91668  1.000 16.51212 ? 592 PHE   B HA   1 
ATOM   1812 H HB2  . PHE   A 1 114 ? 12.15381  -0.32075  39.16147  1.000 16.92495 ? 592 PHE   B HB2  1 
ATOM   1813 H HB3  . PHE   A 1 114 ? 12.75294  1.13309   39.39128  1.000 16.92495 ? 592 PHE   B HB3  1 
ATOM   1814 H HD1  . PHE   A 1 114 ? 13.56246  2.37624   37.43722  1.000 15.24354 ? 592 PHE   B HD1  1 
ATOM   1815 H HD2  . PHE   A 1 114 ? 11.77216  -1.11945  36.96080  1.000 17.75413 ? 592 PHE   B HD2  1 
ATOM   1816 H HE1  . PHE   A 1 114 ? 13.34911  2.80768   35.19214  1.000 16.96515 ? 592 PHE   B HE1  1 
ATOM   1817 H HE2  . PHE   A 1 114 ? 11.49635  -0.65971  34.69849  1.000 19.92992 ? 592 PHE   B HE2  1 
ATOM   1818 H HZ   . PHE   A 1 114 ? 12.30445  1.29831   33.81579  1.000 21.13502 ? 592 PHE   B HZ   1 
ATOM   1819 N N    . ALA   A 1 115 ? 15.12322  0.38915   41.34601  1.000 14.86704 ? 593 ALA   B N    1 
ATOM   1820 C CA   . ALA   A 1 115 ? 15.47376  0.23831   42.75148  1.000 15.39809 ? 593 ALA   B CA   1 
ATOM   1821 C C    . ALA   A 1 115 ? 14.63050  1.13438   43.65744  1.000 14.76232 ? 593 ALA   B C    1 
ATOM   1822 O O    . ALA   A 1 115 ? 14.33184  2.27517   43.32036  1.000 14.82753 ? 593 ALA   B O    1 
ATOM   1823 C CB   . ALA   A 1 115 ? 16.95992  0.58973   42.96358  1.000 15.63673 ? 593 ALA   B CB   1 
ATOM   1824 H H    . ALA   A 1 115 ? 15.41817  1.11279   40.98691  1.000 17.79446 ? 593 ALA   B H    1 
ATOM   1825 H HA   . ALA   A 1 115 ? 15.29983  -0.68091  43.00775  1.000 18.43172 ? 593 ALA   B HA   1 
ATOM   1826 H HB1  . ALA   A 1 115 ? 17.19349  0.42772   43.89100  1.000 18.71810 ? 593 ALA   B HB1  1 
ATOM   1827 H HB2  . ALA   A 1 115 ? 17.50210  0.03235   42.38370  1.000 18.71810 ? 593 ALA   B HB2  1 
ATOM   1828 H HB3  . ALA   A 1 115 ? 17.09738  1.52505   42.74638  1.000 18.71810 ? 593 ALA   B HB3  1 
ATOM   1829 N N    . VAL   A 1 116 ? 14.30201  0.62440   44.84373  1.000 13.85379 ? 594 VAL   B N    1 
ATOM   1830 C CA   . VAL   A 1 116 ? 13.62872  1.43888   45.85312  1.000 15.91125 ? 594 VAL   B CA   1 
ATOM   1831 C C    . VAL   A 1 116 ? 14.59638  2.45855   46.42980  1.000 16.86659 ? 594 VAL   B C    1 
ATOM   1832 O O    . VAL   A 1 116 ? 14.22743  3.61809   46.65975  1.000 17.13575 ? 594 VAL   B O    1 
ATOM   1833 C CB   . VAL   A 1 116 ? 13.04936  0.54139   46.96038  1.000 15.41540 ? 594 VAL   B CB   1 
ATOM   1834 C CG1  . VAL   A 1 116 ? 12.63450  1.33284   48.15916  1.000 18.25211 ? 594 VAL   B CG1  1 
ATOM   1835 C CG2  . VAL   A 1 116 ? 11.87741  -0.29215  46.42759  1.000 17.75493 ? 594 VAL   B CG2  1 
ATOM   1836 H H    . VAL   A 1 116 ? 14.45657  -0.18547  45.08832  1.000 16.57856 ? 594 VAL   B H    1 
ATOM   1837 H HA   . VAL   A 1 116 ? 12.89551  1.91251   45.43006  1.000 19.04752 ? 594 VAL   B HA   1 
ATOM   1838 H HB   . VAL   A 1 116 ? 13.75033  -0.06506  47.24630  1.000 18.45250 ? 594 VAL   B HB   1 
ATOM   1839 H HG11 . VAL   A 1 116 ? 12.04115  0.79276   48.70428  1.000 21.85654 ? 594 VAL   B HG11 1 
ATOM   1840 H HG12 . VAL   A 1 116 ? 13.42462  1.57263   48.66818  1.000 21.85654 ? 594 VAL   B HG12 1 
ATOM   1841 H HG13 . VAL   A 1 116 ? 12.17484  2.13463   47.86462  1.000 21.85654 ? 594 VAL   B HG13 1 
ATOM   1842 H HG21 . VAL   A 1 116 ? 11.53788  -0.85286  47.14259  1.000 21.25993 ? 594 VAL   B HG21 1 
ATOM   1843 H HG22 . VAL   A 1 116 ? 11.17997  0.30606   46.11677  1.000 21.25993 ? 594 VAL   B HG22 1 
ATOM   1844 H HG23 . VAL   A 1 116 ? 12.19043  -0.84458  45.69428  1.000 21.25993 ? 594 VAL   B HG23 1 
ATOM   1845 N N    . ASP   A 1 117 ? 15.84014  2.04176   46.66280  1.000 17.10298 ? 595 ASP   B N    1 
ATOM   1846 C CA   . ASP   A 1 117 ? 16.87044  2.85797   47.29929  1.000 18.24139 ? 595 ASP   B CA   1 
ATOM   1847 C C    . ASP   A 1 117 ? 17.84545  3.39311   46.26394  1.000 16.69553 ? 595 ASP   B C    1 
ATOM   1848 O O    . ASP   A 1 117 ? 18.42816  2.62989   45.48542  1.000 16.57193 ? 595 ASP   B O    1 
ATOM   1849 C CB   . ASP   A 1 117 ? 17.65127  2.04167   48.34159  1.000 18.90956 ? 595 ASP   B CB   1 
ATOM   1850 C CG   . ASP   A 1 117 ? 16.79437  1.58734   49.48269  1.000 22.34995 ? 595 ASP   B CG   1 
ATOM   1851 O OD1  . ASP   A 1 117 ? 15.79379  2.27306   49.79519  1.000 19.70442 ? 595 ASP   B OD1  1 
ATOM   1852 O OD2  . ASP   A 1 117 ? 17.14838  0.54258   50.05953  1.000 23.69890 ? 595 ASP   B OD2  1 
ATOM   1853 H H    . ASP   A 1 117 ? 16.12200  1.25707   46.45204  1.000 20.47759 ? 595 ASP   B H    1 
ATOM   1854 H HA   . ASP   A 1 117 ? 16.43684  3.60908   47.73370  1.000 21.84368 ? 595 ASP   B HA   1 
ATOM   1855 H HB2  . ASP   A 1 117 ? 18.02221  1.25442   47.91317  1.000 22.64549 ? 595 ASP   B HB2  1 
ATOM   1856 H HB3  . ASP   A 1 117 ? 18.36510  2.59035   48.70255  1.000 22.64549 ? 595 ASP   B HB3  1 
ATOM   1857 N N    . ALA   A 1 118 ? 18.08017  4.69804   46.30789  1.000 16.96850 ? 596 ALA   B N    1 
ATOM   1858 C CA   . ALA   A 1 118 ? 19.05579  5.29017   45.40458  1.000 16.52444 ? 596 ALA   B CA   1 
ATOM   1859 C C    . ALA   A 1 118 ? 20.44623  4.66614   45.57884  1.000 16.45618 ? 596 ALA   B C    1 
ATOM   1860 O O    . ALA   A 1 118 ? 21.19459  4.52792   44.60432  1.000 15.70254 ? 596 ALA   B O    1 
ATOM   1861 C CB   . ALA   A 1 118 ? 19.10163  6.79893   45.63861  1.000 18.41727 ? 596 ALA   B CB   1 
ATOM   1862 H H    . ALA   A 1 118 ? 17.69579  5.25279   46.84090  1.000 20.31621 ? 596 ALA   B H    1 
ATOM   1863 H HA   . ALA   A 1 118 ? 18.78521  5.13103   44.48678  1.000 19.78334 ? 596 ALA   B HA   1 
ATOM   1864 H HB1  . ALA   A 1 118 ? 19.75169  7.19242   45.03571  1.000 22.05474 ? 596 ALA   B HB1  1 
ATOM   1865 H HB2  . ALA   A 1 118 ? 18.22288  7.17200   45.46679  1.000 22.05474 ? 596 ALA   B HB2  1 
ATOM   1866 H HB3  . ALA   A 1 118 ? 19.35874  6.96816   46.55847  1.000 22.05474 ? 596 ALA   B HB3  1 
ATOM   1867 N N    . SER   A 1 119 ? 20.77696  4.23754   46.79519  1.000 16.46787 ? 597 SER   B N    1 
ATOM   1868 C CA   . SER   A 1 119 ? 22.07738  3.62695   47.03125  1.000 19.15581 ? 597 SER   B CA   1 
ATOM   1869 C C    . SER   A 1 119 ? 22.33140  2.44056   46.11640  1.000 17.81951 ? 597 SER   B C    1 
ATOM   1870 O O    . SER   A 1 119 ? 23.47220  2.17307   45.72570  1.000 17.42251 ? 597 SER   B O    1 
ATOM   1871 C CB   . SER   A 1 119 ? 22.19202  3.17525   48.48748  1.000 18.69659 ? 597 SER   B CB   1 
ATOM   1872 O OG   . SER   A 1 119 ? 21.10329  2.37307   48.87780  1.000 19.62270 ? 597 SER   B OG   1 
ATOM   1873 H H    . SER   A 1 119 ? 20.27273  4.28843   47.49000  1.000 19.71546 ? 597 SER   B H    1 
ATOM   1874 H HA   . SER   A 1 119 ? 22.75621  4.29720   46.85560  1.000 22.94099 ? 597 SER   B HA   1 
ATOM   1875 H HB2  . SER   A 1 119 ? 23.00901  2.66267   48.59087  1.000 22.38993 ? 597 SER   B HB2  1 
ATOM   1876 H HB3  . SER   A 1 119 ? 22.21913  3.96091   49.05574  1.000 22.38993 ? 597 SER   B HB3  1 
ATOM   1877 H HG   . SER   A 1 119 ? 21.06475  1.68652   48.39535  1.000 23.50125 ? 597 SER   B HG   1 
ATOM   1878 N N    . TYR   A 1 120 ? 21.29197  1.70806   45.77294  1.000 17.18073 ? 598 TYR   B N    1 
ATOM   1879 C CA   . TYR   A 1 120 ? 21.45582  0.54757   44.90953  1.000 17.79624 ? 598 TYR   B CA   1 
ATOM   1880 C C    . TYR   A 1 120 ? 21.77990  0.97123   43.48381  1.000 18.51408 ? 598 TYR   B C    1 
ATOM   1881 O O    . TYR   A 1 120 ? 22.71679  0.45081   42.85276  1.000 18.38677 ? 598 TYR   B O    1 
ATOM   1882 C CB   . TYR   A 1 120 ? 20.16483  -0.28859  44.95960  1.000 17.60716 ? 598 TYR   B CB   1 
ATOM   1883 C CG   . TYR   A 1 120 ? 20.28125  -1.65436  44.30306  1.000 22.18442 ? 598 TYR   B CG   1 
ATOM   1884 C CD1  . TYR   A 1 120 ? 21.15547  -2.60877  44.80280  1.000 25.53312 ? 598 TYR   B CD1  1 
ATOM   1885 C CD2  . TYR   A 1 120 ? 19.52114  -1.98616  43.21591  1.000 29.64332 ? 598 TYR   B CD2  1 
ATOM   1886 C CE1  . TYR   A 1 120 ? 21.25514  -3.85697  44.21758  1.000 30.24950 ? 598 TYR   B CE1  1 
ATOM   1887 C CE2  . TYR   A 1 120 ? 19.61225  -3.24153  42.62461  1.000 32.21440 ? 598 TYR   B CE2  1 
ATOM   1888 C CZ   . TYR   A 1 120 ? 20.47020  -4.15586  43.12567  1.000 25.05599 ? 598 TYR   B CZ   1 
ATOM   1889 O OH   . TYR   A 1 120 ? 20.56664  -5.40377  42.54699  1.000 28.99572 ? 598 TYR   B OH   1 
ATOM   1890 H H    . TYR   A 1 120 ? 20.48231  1.85614   46.02220  1.000 20.57088 ? 598 TYR   B H    1 
ATOM   1891 H HA   . TYR   A 1 120 ? 22.19275  0.00098   45.22430  1.000 21.30951 ? 598 TYR   B HA   1 
ATOM   1892 H HB2  . TYR   A 1 120 ? 19.92165  -0.42832  45.88817  1.000 21.08261 ? 598 TYR   B HB2  1 
ATOM   1893 H HB3  . TYR   A 1 120 ? 19.46178  0.19871   44.50226  1.000 21.08261 ? 598 TYR   B HB3  1 
ATOM   1894 H HD1  . TYR   A 1 120 ? 21.68192  -2.40577  45.54209  1.000 30.59376 ? 598 TYR   B HD1  1 
ATOM   1895 H HD2  . TYR   A 1 120 ? 18.93090  -1.35918  42.86460  1.000 35.52600 ? 598 TYR   B HD2  1 
ATOM   1896 H HE1  . TYR   A 1 120 ? 21.84648  -4.48904  44.55772  1.000 36.25342 ? 598 TYR   B HE1  1 
ATOM   1897 H HE2  . TYR   A 1 120 ? 19.08482  -3.45029  41.88763  1.000 38.61129 ? 598 TYR   B HE2  1 
ATOM   1898 H HH   . TYR   A 1 120 ? 20.27847  -5.37781  41.75839  1.000 34.74888 ? 598 TYR   B HH   1 
ATOM   1899 N N    . SER   A 1 121 ? 21.01410  1.90835   42.94809  1.000 14.73828 ? 599 SER   B N    1 
ATOM   1900 C CA   . SER   A 1 121 ? 21.31891  2.44397   41.63601  1.000 16.53351 ? 599 SER   B CA   1 
ATOM   1901 C C    . SER   A 1 121 ? 22.63224  3.22791   41.60973  1.000 15.16491 ? 599 SER   B C    1 
ATOM   1902 O O    . SER   A 1 121 ? 23.19349  3.42765   40.52940  1.000 15.44090 ? 599 SER   B O    1 
ATOM   1903 C CB   . SER   A 1 121 ? 20.18772  3.37177   41.17804  1.000 16.23957 ? 599 SER   B CB   1 
ATOM   1904 O OG   . SER   A 1 121 ? 18.96090  2.66770   41.21287  1.000 15.17666 ? 599 SER   B OG   1 
ATOM   1905 H H    . SER   A 1 121 ? 20.31775  2.24786   43.32151  1.000 17.63995 ? 599 SER   B H    1 
ATOM   1906 H HA   . SER   A 1 121 ? 21.39297  1.70099   41.01682  1.000 19.79422 ? 599 SER   B HA   1 
ATOM   1907 H HB2  . SER   A 1 121 ? 20.13722  4.13575   41.77359  1.000 19.44150 ? 599 SER   B HB2  1 
ATOM   1908 H HB3  . SER   A 1 121 ? 20.36250  3.66889   40.27136  1.000 19.44150 ? 599 SER   B HB3  1 
ATOM   1909 H HG   . SER   A 1 121 ? 18.32998  3.17908   40.99833  1.000 18.16600 ? 599 SER   B HG   1 
ATOM   1910 N N    . ALA   A 1 122 ? 23.10241  3.69404   42.75403  1.000 15.71419 ? 600 ALA   B N    1 
ATOM   1911 C CA   . ALA   A 1 122 ? 24.34356  4.46685   42.78973  1.000 17.58750 ? 600 ALA   B CA   1 
ATOM   1912 C C    . ALA   A 1 122 ? 25.58545  3.60524   42.63198  1.000 19.19778 ? 600 ALA   B C    1 
ATOM   1913 O O    . ALA   A 1 122 ? 26.68278  4.14174   42.46036  1.000 17.98803 ? 600 ALA   B O    1 
ATOM   1914 C CB   . ALA   A 1 122 ? 24.41820  5.25438   44.09640  1.000 18.28154 ? 600 ALA   B CB   1 
ATOM   1915 H H    . ALA   A 1 122 ? 22.72860  3.58038   43.52015  1.000 18.81104 ? 600 ALA   B H    1 
ATOM   1916 H HA   . ALA   A 1 122 ? 24.34043  5.10243   42.05697  1.000 21.05901 ? 600 ALA   B HA   1 
ATOM   1917 H HB1  . ALA   A 1 122 ? 25.24449  5.76221   44.11229  1.000 21.89186 ? 600 ALA   B HB1  1 
ATOM   1918 H HB2  . ALA   A 1 122 ? 23.65908  5.85617   44.14623  1.000 21.89186 ? 600 ALA   B HB2  1 
ATOM   1919 H HB3  . ALA   A 1 122 ? 24.39733  4.63321   44.84112  1.000 21.89186 ? 600 ALA   B HB3  1 
ATOM   1920 N N    . LYS   A 1 123 ? 25.44723  2.28706   42.68070  1.000 15.61178 ? 601 LYS   B N    1 
ATOM   1921 C CA   . LYS   A 1 123 ? 26.60791  1.41697   42.45121  1.000 18.28702 ? 601 LYS   B CA   1 
ATOM   1922 C C    . LYS   A 1 123 ? 27.20001  1.64680   41.07490  1.000 19.52566 ? 601 LYS   B C    1 
ATOM   1923 O O    . LYS   A 1 123 ? 26.48020  1.85555   40.10335  1.000 16.15609 ? 601 LYS   B O    1 
ATOM   1924 C CB   . LYS   A 1 123 ? 26.18569  -0.04925  42.61864  1.000 18.81945 ? 601 LYS   B CB   1 
ATOM   1925 C CG   . LYS   A 1 123 ? 25.79405  -0.35886  44.08161  1.000 22.72552 ? 601 LYS   B CG   1 
ATOM   1926 C CD   . LYS   A 1 123 ? 25.25602  -1.78828  44.22843  1.000 29.03431 ? 601 LYS   B CD   1 
ATOM   1927 C CE   . LYS   A 1 123 ? 26.31063  -2.83009  43.98008  1.000 45.97909 ? 601 LYS   B CE   1 
ATOM   1928 N NZ   . LYS   A 1 123 ? 25.76091  -4.20493  44.18159  1.000 43.79311 ? 601 LYS   B NZ   1 
ATOM   1929 H H    . LYS   A 1 123 ? 24.71058  1.87319   42.84088  1.000 18.68815 ? 601 LYS   B H    1 
ATOM   1930 H HA   . LYS   A 1 123 ? 27.30014  1.61805   43.10027  1.000 21.89844 ? 601 LYS   B HA   1 
ATOM   1931 H HB2  . LYS   A 1 123 ? 25.41946  -0.22940  42.05178  1.000 22.53735 ? 601 LYS   B HB2  1 
ATOM   1932 H HB3  . LYS   A 1 123 ? 26.92479  -0.62646  42.37074  1.000 22.53735 ? 601 LYS   B HB3  1 
ATOM   1933 H HG2  . LYS   A 1 123 ? 26.57490  -0.26705  44.64971  1.000 27.22464 ? 601 LYS   B HG2  1 
ATOM   1934 H HG3  . LYS   A 1 123 ? 25.10204  0.25825   44.36658  1.000 27.22464 ? 601 LYS   B HG3  1 
ATOM   1935 H HD2  . LYS   A 1 123 ? 24.92037  -1.90979  45.13035  1.000 34.79519 ? 601 LYS   B HD2  1 
ATOM   1936 H HD3  . LYS   A 1 123 ? 24.54132  -1.92562  43.58715  1.000 34.79519 ? 601 LYS   B HD3  1 
ATOM   1937 H HE2  . LYS   A 1 123 ? 26.62851  -2.75695  43.06656  1.000 55.12892 ? 601 LYS   B HE2  1 
ATOM   1938 H HE3  . LYS   A 1 123 ? 27.04619  -2.69939  44.59876  1.000 55.12892 ? 601 LYS   B HE3  1 
ATOM   1939 H HZ1  . LYS   A 1 123 ? 25.08449  -4.34749  43.62102  1.000 52.50575 ? 601 LYS   B HZ1  1 
ATOM   1940 H HZ2  . LYS   A 1 123 ? 26.39445  -4.81133  44.02990  1.000 52.50575 ? 601 LYS   B HZ2  1 
ATOM   1941 H HZ3  . LYS   A 1 123 ? 25.46785  -4.29616  45.01699  1.000 52.50575 ? 601 LYS   B HZ3  1 
ATOM   1942 N N    . ASP   A 1 124 ? 28.53679  1.62300   40.99406  1.000 20.51337 ? 602 ASP   B N    1 
ATOM   1943 C CA   . ASP   A 1 124 ? 29.20456  1.84915   39.72176  1.000 18.31876 ? 602 ASP   B CA   1 
ATOM   1944 C C    . ASP   A 1 124 ? 28.77456  0.86337   38.65129  1.000 19.77216 ? 602 ASP   B C    1 
ATOM   1945 O O    . ASP   A 1 124 ? 28.87064  1.16896   37.46479  1.000 17.90988 ? 602 ASP   B O    1 
ATOM   1946 C CB   . ASP   A 1 124 ? 30.73381  1.77563   39.90498  1.000 22.97057 ? 602 ASP   B CB   1 
ATOM   1947 C CG   . ASP   A 1 124 ? 31.32822  3.03402   40.52495  1.000 27.74119 ? 602 ASP   B CG   1 
ATOM   1948 O OD1  . ASP   A 1 124 ? 30.59422  3.97705   40.81357  1.000 20.51605 ? 602 ASP   B OD1  1 
ATOM   1949 O OD2  . ASP   A 1 124 ? 32.55863  3.07884   40.73010  1.000 23.65748 ? 602 ASP   B OD2  1 
ATOM   1950 H H    . ASP   A 1 124 ? 29.06693  1.47949   41.65584  1.000 24.57006 ? 602 ASP   B H    1 
ATOM   1951 H HA   . ASP   A 1 124 ? 28.96930  2.73983   39.41804  1.000 21.93653 ? 602 ASP   B HA   1 
ATOM   1952 H HB2  . ASP   A 1 124 ? 30.94469  1.02897   40.48715  1.000 27.51870 ? 602 ASP   B HB2  1 
ATOM   1953 H HB3  . ASP   A 1 124 ? 31.14811  1.64716   39.03737  1.000 27.51870 ? 602 ASP   B HB3  1 
ATOM   1954 N N    A THR   A 1 125 ? 28.30638  -0.31756  39.04462  0.637 20.55703 ? 603 THR   B N    1 
ATOM   1955 N N    B THR   A 1 125 ? 28.31134  -0.32299  39.03955  0.363 20.60676 ? 603 THR   B N    1 
ATOM   1956 C CA   A THR   A 1 125 ? 27.85633  -1.29902  38.05917  0.637 21.22399 ? 603 THR   B CA   1 
ATOM   1957 C CA   B THR   A 1 125 ? 27.87044  -1.29711  38.04371  0.363 21.27166 ? 603 THR   B CA   1 
ATOM   1958 C C    A THR   A 1 125 ? 26.66556  -0.79570  37.26548  0.637 21.09118 ? 603 THR   B C    1 
ATOM   1959 C C    B THR   A 1 125 ? 26.63993  -0.83220  37.28277  0.363 21.11413 ? 603 THR   B C    1 
ATOM   1960 O O    A THR   A 1 125 ? 26.46993  -1.19938  36.11454  0.637 21.16943 ? 603 THR   B O    1 
ATOM   1961 O O    B THR   A 1 125 ? 26.40160  -1.30276  36.16516  0.363 21.18474 ? 603 THR   B O    1 
ATOM   1962 C CB   A THR   A 1 125 ? 27.48951  -2.60665  38.76402  0.637 22.74861 ? 603 THR   B CB   1 
ATOM   1963 C CB   B THR   A 1 125 ? 27.57160  -2.64485  38.70674  0.363 22.79012 ? 603 THR   B CB   1 
ATOM   1964 O OG1  A THR   A 1 125 ? 28.47000  -2.87199  39.78740  0.637 27.21015 ? 603 THR   B OG1  1 
ATOM   1965 O OG1  B THR   A 1 125 ? 26.72375  -2.46109  39.84561  0.363 22.50416 ? 603 THR   B OG1  1 
ATOM   1966 C CG2  A THR   A 1 125 ? 27.45709  -3.74994  37.76165  0.637 21.09186 ? 603 THR   B CG2  1 
ATOM   1967 C CG2  B THR   A 1 125 ? 28.87415  -3.31220  39.14480  0.363 27.34503 ? 603 THR   B CG2  1 
ATOM   1968 H H    A THR   A 1 125 ? 28.23893  -0.57355  39.86286  0.637 24.62245 ? 603 THR   B H    1 
ATOM   1969 H H    B THR   A 1 125 ? 28.24325  -0.58367  39.85625  0.363 24.68213 ? 603 THR   B H    1 
ATOM   1970 H HA   A THR   A 1 125 ? 28.58234  -1.47040  37.43915  0.637 25.42281 ? 603 THR   B HA   1 
ATOM   1971 H HA   B THR   A 1 125 ? 28.59304  -1.42498  37.40936  0.363 25.48000 ? 603 THR   B HA   1 
ATOM   1972 H HB   A THR   A 1 125 ? 26.61067  -2.54080  39.16924  0.637 27.25234 ? 603 THR   B HB   1 
ATOM   1973 H HB   B THR   A 1 125 ? 27.11991  -3.22282  38.07205  0.363 27.30216 ? 603 THR   B HB   1 
ATOM   1974 H HG1  A THR   A 1 125 ? 28.35767  -2.34932  40.43532  0.637 32.60619 ? 603 THR   B HG1  1 
ATOM   1975 H HG1  B THR   A 1 125 ? 25.99629  -2.11394  39.60919  0.363 26.95901 ? 603 THR   B HG1  1 
ATOM   1976 H HG21 A THR   A 1 125 ? 26.85488  -4.44487  38.07040  0.637 25.26424 ? 603 THR   B HG21 1 
ATOM   1977 H HG21 B THR   A 1 125 ? 28.68690  -4.01806  39.78323  0.363 32.76805 ? 603 THR   B HG21 1 
ATOM   1978 H HG22 A THR   A 1 125 ? 27.14991  -3.42715  36.90005  0.637 25.26424 ? 603 THR   B HG22 1 
ATOM   1979 H HG22 B THR   A 1 125 ? 29.32583  -3.69455  38.37624  0.363 32.76805 ? 603 THR   B HG22 1 
ATOM   1980 H HG23 A THR   A 1 125 ? 28.34525  -4.12602  37.65852  0.637 25.26424 ? 603 THR   B HG23 1 
ATOM   1981 H HG23 B THR   A 1 125 ? 29.45830  -2.65874  39.56032  0.363 32.76805 ? 603 THR   B HG23 1 
ATOM   1982 N N    . TYR   A 1 126 ? 25.84707  0.06767   37.86555  1.000 18.95011 ? 604 TYR   B N    1 
ATOM   1983 C CA   . TYR   A 1 126 ? 24.66822  0.62172   37.18836  1.000 19.92905 ? 604 TYR   B CA   1 
ATOM   1984 C C    . TYR   A 1 126 ? 24.93298  2.04001   36.68842  1.000 19.75280 ? 604 TYR   B C    1 
ATOM   1985 O O    . TYR   A 1 126 ? 24.94147  2.28472   35.47620  1.000 20.44401 ? 604 TYR   B O    1 
ATOM   1986 C CB   . TYR   A 1 126 ? 23.46209  0.58913   38.12883  1.000 19.93216 ? 604 TYR   B CB   1 
ATOM   1987 C CG   . TYR   A 1 126 ? 23.22573  -0.76687  38.74038  1.000 21.18222 ? 604 TYR   B CG   1 
ATOM   1988 C CD1  . TYR   A 1 126 ? 22.98980  -1.86964  37.94146  1.000 22.91004 ? 604 TYR   B CD1  1 
ATOM   1989 C CD2  . TYR   A 1 126 ? 23.25255  -0.94565  40.11190  1.000 21.95031 ? 604 TYR   B CD2  1 
ATOM   1990 C CE1  . TYR   A 1 126 ? 22.78687  -3.14263  38.50706  1.000 23.65843 ? 604 TYR   B CE1  1 
ATOM   1991 C CE2  . TYR   A 1 126 ? 23.05523  -2.17735  40.67891  1.000 25.81827 ? 604 TYR   B CE2  1 
ATOM   1992 C CZ   . TYR   A 1 126 ? 22.81896  -3.27330  39.87238  1.000 27.89700 ? 604 TYR   B CZ   1 
ATOM   1993 O OH   . TYR   A 1 126 ? 22.62057  -4.50399  40.45548  1.000 26.24788 ? 604 TYR   B OH   1 
ATOM   1994 H H    A TYR   A 1 126 ? 25.95179  0.35159   38.67055  0.637 22.69414 ? 604 TYR   B H    1 
ATOM   1995 H H    B TYR   A 1 126 ? 25.97010  0.37670   38.65863  0.363 22.69414 ? 604 TYR   B H    1 
ATOM   1996 H HA   . TYR   A 1 126 ? 24.45315  0.07015   36.41998  1.000 23.86887 ? 604 TYR   B HA   1 
ATOM   1997 H HB2  . TYR   A 1 126 ? 23.60879  1.22082   38.85019  1.000 23.87260 ? 604 TYR   B HB2  1 
ATOM   1998 H HB3  . TYR   A 1 126 ? 22.66745  0.83440   37.62954  1.000 23.87260 ? 604 TYR   B HB3  1 
ATOM   1999 H HD1  . TYR   A 1 126 ? 22.96474  -1.76929  37.01723  1.000 27.44607 ? 604 TYR   B HD1  1 
ATOM   2000 H HD2  . TYR   A 1 126 ? 23.40823  -0.21231  40.66225  1.000 26.29439 ? 604 TYR   B HD2  1 
ATOM   2001 H HE1  . TYR   A 1 126 ? 22.63369  -3.88231  37.96456  1.000 28.34413 ? 604 TYR   B HE1  1 
ATOM   2002 H HE2  . TYR   A 1 126 ? 23.08032  -2.27498  41.60343  1.000 30.93594 ? 604 TYR   B HE2  1 
ATOM   2003 H HH   . TYR   A 1 126 ? 22.47745  -5.08262  39.86361  1.000 31.45147 ? 604 TYR   B HH   1 
ATOM   2004 N N    . SER   A 1 127 ? 25.16162  2.97677   37.61088  1.000 18.02863 ? 605 SER   B N    1 
ATOM   2005 C CA   . SER   A 1 127 ? 25.47791  4.36725   37.24128  1.000 16.51393 ? 605 SER   B CA   1 
ATOM   2006 C C    . SER   A 1 127 ? 26.98008  4.52770   36.98208  1.000 17.37665 ? 605 SER   B C    1 
ATOM   2007 O O    . SER   A 1 127 ? 27.71745  5.13395   37.74047  1.000 17.70147 ? 605 SER   B O    1 
ATOM   2008 C CB   . SER   A 1 127 ? 24.97728  5.31479   38.32275  1.000 15.67455 ? 605 SER   B CB   1 
ATOM   2009 O OG   . SER   A 1 127 ? 25.34433  4.90097   39.60773  1.000 15.78511 ? 605 SER   B OG   1 
ATOM   2010 H H    . SER   A 1 127 ? 25.14041  2.83621   38.45905  1.000 21.58836 ? 605 SER   B H    1 
ATOM   2011 H HA   . SER   A 1 127 ? 25.02465  4.57776   36.40993  1.000 19.77073 ? 605 SER   B HA   1 
ATOM   2012 H HB2  . SER   A 1 127 ? 25.35357  6.19422   38.16179  1.000 18.76347 ? 605 SER   B HB2  1 
ATOM   2013 H HB3  . SER   A 1 127 ? 24.00925  5.35438   38.27532  1.000 18.76347 ? 605 SER   B HB3  1 
ATOM   2014 H HG   . SER   A 1 127 ? 24.93855  4.19343   39.80856  1.000 18.89614 ? 605 SER   B HG   1 
ATOM   2015 N N    . LYS   A 1 128 ? 27.41734  3.94619   35.87217  1.000 17.29750 ? 606 LYS   B N    1 
ATOM   2016 C CA   . LYS   A 1 128 ? 28.82879  3.89966   35.56154  1.000 20.66135 ? 606 LYS   B CA   1 
ATOM   2017 C C    . LYS   A 1 128 ? 29.37271  5.31349   35.44551  1.000 18.69576 ? 606 LYS   B C    1 
ATOM   2018 O O    . LYS   A 1 128 ? 28.83222  6.11261   34.66101  1.000 18.79021 ? 606 LYS   B O    1 
ATOM   2019 C CB   . LYS   A 1 128 ? 29.03188  3.14928   34.25398  1.000 21.85319 ? 606 LYS   B CB   1 
ATOM   2020 C CG   . LYS   A 1 128 ? 30.43154  3.18554   33.70216  1.000 29.25098 ? 606 LYS   B CG   1 
ATOM   2021 C CD   . LYS   A 1 128 ? 30.49549  2.35738   32.41297  1.000 42.42470 ? 606 LYS   B CD   1 
ATOM   2022 C CE   . LYS   A 1 128 ? 31.79705  2.57420   31.66097  1.000 40.48273 ? 606 LYS   B CE   1 
ATOM   2023 N NZ   . LYS   A 1 128 ? 31.72954  1.93040   30.32793  1.000 46.89846 ? 606 LYS   B NZ   1 
ATOM   2024 H H    . LYS   A 1 128 ? 26.91312  3.57198   35.28452  1.000 20.71101 ? 606 LYS   B H    1 
ATOM   2025 H HA   . LYS   A 1 128 ? 29.31469  3.44225   36.26551  1.000 24.74763 ? 606 LYS   B HA   1 
ATOM   2026 H HB2  . LYS   A 1 128 ? 28.80103  2.21804   34.39683  1.000 26.17785 ? 606 LYS   B HB2  1 
ATOM   2027 H HB3  . LYS   A 1 128 ? 28.44668  3.53726   33.58472  1.000 26.17785 ? 606 LYS   B HB3  1 
ATOM   2028 H HG2  . LYS   A 1 128 ? 30.68144  4.10057   33.49929  1.000 35.05519 ? 606 LYS   B HG2  1 
ATOM   2029 H HG3  . LYS   A 1 128 ? 31.04941  2.80823   34.34773  1.000 35.05519 ? 606 LYS   B HG3  1 
ATOM   2030 H HD2  . LYS   A 1 128 ? 30.42735  1.41554   32.63474  1.000 50.86366 ? 606 LYS   B HD2  1 
ATOM   2031 H HD3  . LYS   A 1 128 ? 29.76330  2.61506   31.83125  1.000 50.86366 ? 606 LYS   B HD3  1 
ATOM   2032 H HE2  . LYS   A 1 128 ? 31.94946  3.52446   31.53975  1.000 48.53329 ? 606 LYS   B HE2  1 
ATOM   2033 H HE3  . LYS   A 1 128 ? 32.53095  2.18137   32.15895  1.000 48.53329 ? 606 LYS   B HE3  1 
ATOM   2034 H HZ1  . LYS   A 1 128 ? 31.06251  2.28070   29.85415  1.000 56.23217 ? 606 LYS   B HZ1  1 
ATOM   2035 H HZ2  . LYS   A 1 128 ? 32.49339  2.05783   29.88931  1.000 56.23217 ? 606 LYS   B HZ2  1 
ATOM   2036 H HZ3  . LYS   A 1 128 ? 31.59110  1.05595   30.41888  1.000 56.23217 ? 606 LYS   B HZ3  1 
ATOM   2037 N N    . PRO   A 1 129 ? 30.44372  5.66362   36.17419  1.000 20.14935 ? 607 PRO   B N    1 
ATOM   2038 C CA   . PRO   A 1 129 ? 31.02060  7.00209   36.00128  1.000 18.96427 ? 607 PRO   B CA   1 
ATOM   2039 C C    . PRO   A 1 129 ? 31.49086  7.19764   34.56562  1.000 20.62336 ? 607 PRO   B C    1 
ATOM   2040 O O    . PRO   A 1 129 ? 32.12867  6.32682   33.97256  1.000 19.72507 ? 607 PRO   B O    1 
ATOM   2041 C CB   . PRO   A 1 129 ? 32.18981  7.02623   37.00320  1.000 23.30487 ? 607 PRO   B CB   1 
ATOM   2042 C CG   . PRO   A 1 129 ? 31.92415  5.88961   37.95408  1.000 23.00630 ? 607 PRO   B CG   1 
ATOM   2043 C CD   . PRO   A 1 129 ? 31.12433  4.88595   37.22368  1.000 22.42414 ? 607 PRO   B CD   1 
ATOM   2044 H HA   . PRO   A 1 129 ? 30.38567  7.69537   36.24029  1.000 22.71114 ? 607 PRO   B HA   1 
ATOM   2045 H HB2  . PRO   A 1 129 ? 33.02812  6.89507   36.53317  1.000 27.91986 ? 607 PRO   B HB2  1 
ATOM   2046 H HB3  . PRO   A 1 129 ? 32.20226  7.87461   37.47331  1.000 27.91986 ? 607 PRO   B HB3  1 
ATOM   2047 H HG2  . PRO   A 1 129 ? 32.76788  5.50649   38.24086  1.000 27.56157 ? 607 PRO   B HG2  1 
ATOM   2048 H HG3  . PRO   A 1 129 ? 31.43228  6.22091   38.72168  1.000 27.56157 ? 607 PRO   B HG3  1 
ATOM   2049 H HD2  . PRO   A 1 129 ? 31.69910  4.21063   36.83064  1.000 26.86298 ? 607 PRO   B HD2  1 
ATOM   2050 H HD3  . PRO   A 1 129 ? 30.47758  4.46851   37.81389  1.000 26.86298 ? 607 PRO   B HD3  1 
ATOM   2051 N N    . ASP   A 1 130 ? 31.21957  8.37207   34.01278  1.000 16.53028 ? 608 ASP   B N    1 
ATOM   2052 C CA   . ASP   A 1 130 ? 31.68481  8.68707   32.67898  1.000 18.99432 ? 608 ASP   B CA   1 
ATOM   2053 C C    . ASP   A 1 130 ? 33.11725  9.20367   32.75452  1.000 18.43443 ? 608 ASP   B C    1 
ATOM   2054 O O    . ASP   A 1 130 ? 33.74447  9.20108   33.81370  1.000 18.27954 ? 608 ASP   B O    1 
ATOM   2055 C CB   . ASP   A 1 130 ? 30.72447  9.66120   31.98827  1.000 18.45789 ? 608 ASP   B CB   1 
ATOM   2056 C CG   . ASP   A 1 130 ? 30.69527  11.05117  32.59546  1.000 20.18105 ? 608 ASP   B CG   1 
ATOM   2057 O OD1  . ASP   A 1 130 ? 31.62297  11.45355  33.31884  1.000 18.67148 ? 608 ASP   B OD1  1 
ATOM   2058 O OD2  . ASP   A 1 130 ? 29.69074  11.76563  32.28174  1.000 18.38398 ? 608 ASP   B OD2  1 
ATOM   2059 H H    . ASP   A 1 130 ? 30.76892  8.99892   34.39170  1.000 19.79035 ? 608 ASP   B H    1 
ATOM   2060 H HA   . ASP   A 1 130 ? 31.69229  7.88476   32.13387  1.000 22.74720 ? 608 ASP   B HA   1 
ATOM   2061 H HB2  . ASP   A 1 130 ? 30.99107  9.75282   31.06013  1.000 22.10349 ? 608 ASP   B HB2  1 
ATOM   2062 H HB3  . ASP   A 1 130 ? 29.82588  9.29978   32.04120  1.000 22.10349 ? 608 ASP   B HB3  1 
ATOM   2063 N N    . SER   A 1 131 ? 33.66153  9.60075   31.61438  1.000 21.59826 ? 609 SER   B N    1 
ATOM   2064 C CA   . SER   A 1 131 ? 35.07046  10.03143  31.56103  1.000 24.57580 ? 609 SER   B CA   1 
ATOM   2065 C C    . SER   A 1 131 ? 35.35129  11.23076  32.45671  1.000 28.11687 ? 609 SER   B C    1 
ATOM   2066 O O    . SER   A 1 131 ? 36.50514  11.45766  32.83147  1.000 25.88426 ? 609 SER   B O    1 
ATOM   2067 C CB   . SER   A 1 131 ? 35.45185  10.37372  30.12829  1.000 24.73517 ? 609 SER   B CB   1 
ATOM   2068 O OG   . SER   A 1 131 ? 34.65541  11.43443  29.62739  1.000 35.91476 ? 609 SER   B OG   1 
ATOM   2069 H H    . SER   A 1 131 ? 33.25040  9.63379   30.85974  1.000 25.87193 ? 609 SER   B H    1 
ATOM   2070 H HA   . SER   A 1 131 ? 35.62519  9.29572   31.86421  1.000 29.44498 ? 609 SER   B HA   1 
ATOM   2071 H HB2  . SER   A 1 131 ? 36.38366  10.64233  30.10629  1.000 29.63622 ? 609 SER   B HB2  1 
ATOM   2072 H HB3  . SER   A 1 131 ? 35.31912  9.59052   29.57162  1.000 29.63622 ? 609 SER   B HB3  1 
ATOM   2073 H HG   . SER   A 1 131 ? 34.87647  11.61093  28.83645  1.000 43.05172 ? 609 SER   B HG   1 
ATOM   2074 N N    . ASN   A 1 132 ? 34.32252  11.99011  32.82060  1.000 22.35178 ? 610 ASN   B N    1 
ATOM   2075 C CA   . ASN   A 1 132 ? 34.46519  13.14536  33.69735  1.000 23.15900 ? 610 ASN   B CA   1 
ATOM   2076 C C    . ASN   A 1 132 ? 34.08113  12.82808  35.12121  1.000 19.91878 ? 610 ASN   B C    1 
ATOM   2077 O O    . ASN   A 1 132 ? 33.94520  13.74454  35.93890  1.000 20.79988 ? 610 ASN   B O    1 
ATOM   2078 C CB   . ASN   A 1 132 ? 33.61415  14.30321  33.17756  1.000 23.85575 ? 610 ASN   B CB   1 
ATOM   2079 C CG   . ASN   A 1 132 ? 34.19036  14.93697  31.93648  1.000 29.63515 ? 610 ASN   B CG   1 
ATOM   2080 O OD1  . ASN   A 1 132 ? 33.63003  14.80959  30.84388  1.000 32.92135 ? 610 ASN   B OD1  1 
ATOM   2081 N ND2  . ASN   A 1 132 ? 35.30563  15.62513  32.09744  1.000 34.11533 ? 610 ASN   B ND2  1 
ATOM   2082 H H    . ASN   A 1 132 ? 33.51281  11.85203  32.56584  1.000 26.77615 ? 610 ASN   B H    1 
ATOM   2083 H HA   . ASN   A 1 132 ? 35.39243  13.43012  33.69111  1.000 27.74482 ? 610 ASN   B HA   1 
ATOM   2084 H HB2  . ASN   A 1 132 ? 32.72798  13.97273  32.96219  1.000 28.58092 ? 610 ASN   B HB2  1 
ATOM   2085 H HB3  . ASN   A 1 132 ? 33.55582  14.98606  33.86400  1.000 28.58092 ? 610 ASN   B HB3  1 
ATOM   2086 H HD21 . ASN   A 1 132 ? 35.67648  16.00710  31.42204  1.000 40.89241 ? 610 ASN   B HD21 1 
ATOM   2087 H HD22 . ASN   A 1 132 ? 35.66121  15.69138  32.87768  1.000 40.89241 ? 610 ASN   B HD22 1 
ATOM   2088 N N    . GLY   A 1 133 ? 33.81567  11.55906  35.42485  1.000 17.98595 ? 611 GLY   B N    1 
ATOM   2089 C CA   . GLY   A 1 133 ? 33.47540  11.20582  36.78106  1.000 18.15429 ? 611 GLY   B CA   1 
ATOM   2090 C C    . GLY   A 1 133 ? 32.02495  11.42483  37.14602  1.000 16.81269 ? 611 GLY   B C    1 
ATOM   2091 O O    . GLY   A 1 133 ? 31.67075  11.32734  38.32200  1.000 19.28609 ? 611 GLY   B O    1 
ATOM   2092 H H    . GLY   A 1 133 ? 33.82814  10.90394  34.86783  1.000 21.53715 ? 611 GLY   B H    1 
ATOM   2093 H HA2  . GLY   A 1 133 ? 33.67712  10.26697  36.91801  1.000 21.73916 ? 611 GLY   B HA2  1 
ATOM   2094 H HA3  . GLY   A 1 133 ? 34.01680  11.73667  37.38603  1.000 21.73916 ? 611 GLY   B HA3  1 
ATOM   2095 N N    . ARG   A 1 134 ? 31.17817  11.71312  36.17513  1.000 16.73941 ? 612 ARG   B N    1 
ATOM   2096 C CA   . ARG   A 1 134 ? 29.76163  11.94208  36.43406  1.000 16.01669 ? 612 ARG   B CA   1 
ATOM   2097 C C    . ARG   A 1 134 ? 28.99725  10.62873  36.38653  1.000 15.73369 ? 612 ARG   B C    1 
ATOM   2098 O O    . ARG   A 1 134 ? 29.20295  9.81076   35.47637  1.000 16.89625 ? 612 ARG   B O    1 
ATOM   2099 C CB   . ARG   A 1 134 ? 29.18007  12.91680  35.41649  1.000 16.42942 ? 612 ARG   B CB   1 
ATOM   2100 C CG   . ARG   A 1 134 ? 29.23770  14.38819  35.84909  1.000 18.36721 ? 612 ARG   B CG   1 
ATOM   2101 C CD   . ARG   A 1 134 ? 30.70118  14.84444  35.98935  1.000 16.13187 ? 612 ARG   B CD   1 
ATOM   2102 N NE   . ARG   A 1 134 ? 30.72252  16.27021  36.34261  1.000 15.34953 ? 612 ARG   B NE   1 
ATOM   2103 C CZ   . ARG   A 1 134 ? 31.83503  16.96196  36.51670  1.000 20.25045 ? 612 ARG   B CZ   1 
ATOM   2104 N NH1  . ARG   A 1 134 ? 33.01242  16.37298  36.41271  1.000 18.51032 ? 612 ARG   B NH1  1 
ATOM   2105 N NH2  . ARG   A 1 134 ? 31.75713  18.25539  36.86870  1.000 17.17121 ? 612 ARG   B NH2  1 
ATOM   2106 H H    . ARG   A 1 134 ? 31.39813  11.78359  35.34672  1.000 20.04130 ? 612 ARG   B H    1 
ATOM   2107 H HA   . ARG   A 1 134 ? 29.66140  12.32140  37.32118  1.000 19.17405 ? 612 ARG   B HA   1 
ATOM   2108 H HB2  . ARG   A 1 134 ? 29.67817  12.83405  34.58827  1.000 19.66932 ? 612 ARG   B HB2  1 
ATOM   2109 H HB3  . ARG   A 1 134 ? 28.24872  12.69032  35.26755  1.000 19.66932 ? 612 ARG   B HB3  1 
ATOM   2110 H HG2  . ARG   A 1 134 ? 28.80278  14.94168  35.18171  1.000 21.99467 ? 612 ARG   B HG2  1 
ATOM   2111 H HG3  . ARG   A 1 134 ? 28.79633  14.49366  36.70639  1.000 21.99467 ? 612 ARG   B HG3  1 
ATOM   2112 H HD2  . ARG   A 1 134 ? 31.13994  14.33838  36.69099  1.000 19.31226 ? 612 ARG   B HD2  1 
ATOM   2113 H HD3  . ARG   A 1 134 ? 31.16875  14.72010  35.14863  1.000 19.31226 ? 612 ARG   B HD3  1 
ATOM   2114 H HE   . ARG   A 1 134 ? 29.97096  16.67639  36.44141  1.000 18.37345 ? 612 ARG   B HE   1 
ATOM   2115 H HH11 . ARG   A 1 134 ? 33.05883  15.53377  36.23059  1.000 22.16640 ? 612 ARG   B HH11 1 
ATOM   2116 H HH12 . ARG   A 1 134 ? 33.73276  16.82864  36.52712  1.000 22.16640 ? 612 ARG   B HH12 1 
ATOM   2117 H HH21 . ARG   A 1 134 ? 30.98871  18.62559  36.97862  1.000 20.55946 ? 612 ARG   B HH21 1 
ATOM   2118 H HH22 . ARG   A 1 134 ? 32.47566  18.71361  36.98424  1.000 20.55946 ? 612 ARG   B HH22 1 
ATOM   2119 N N    . LYS   A 1 135 ? 28.14885  10.42674  37.38209  1.000 14.84381 ? 613 LYS   B N    1 
ATOM   2120 C CA   . LYS   A 1 135 ? 27.23912  9.29084   37.44512  1.000 14.96041 ? 613 LYS   B CA   1 
ATOM   2121 C C    . LYS   A 1 135 ? 25.82946  9.77870   37.17234  1.000 14.79531 ? 613 LYS   B C    1 
ATOM   2122 O O    . LYS   A 1 135 ? 25.49963  10.92226  37.46811  1.000 13.59886 ? 613 LYS   B O    1 
ATOM   2123 C CB   . LYS   A 1 135 ? 27.34959  8.62792   38.80835  1.000 14.83715 ? 613 LYS   B CB   1 
ATOM   2124 C CG   . LYS   A 1 135 ? 28.74657  7.97164   39.04681  1.000 15.10485 ? 613 LYS   B CG   1 
ATOM   2125 C CD   . LYS   A 1 135 ? 28.95559  7.68886   40.52500  1.000 15.96083 ? 613 LYS   B CD   1 
ATOM   2126 C CE   . LYS   A 1 135 ? 28.04504  6.63491   41.09060  1.000 20.07092 ? 613 LYS   B CE   1 
ATOM   2127 N NZ   . LYS   A 1 135 ? 28.13347  5.32044   40.38406  1.000 18.38670 ? 613 LYS   B NZ   1 
ATOM   2128 H H    . LYS   A 1 135 ? 28.07776  10.95274  38.05875  1.000 17.76659 ? 613 LYS   B H    1 
ATOM   2129 H HA   . LYS   A 1 135 ? 27.44770  8.62042   36.77584  1.000 17.90651 ? 613 LYS   B HA   1 
ATOM   2130 H HB2  . LYS   A 1 135 ? 27.20980  9.29646   39.49713  1.000 17.75859 ? 613 LYS   B HB2  1 
ATOM   2131 H HB3  . LYS   A 1 135 ? 26.67542  7.93397   38.87788  1.000 17.75859 ? 613 LYS   B HB3  1 
ATOM   2132 H HG2  . LYS   A 1 135 ? 28.79931  7.13358   38.56124  1.000 18.07984 ? 613 LYS   B HG2  1 
ATOM   2133 H HG3  . LYS   A 1 135 ? 29.44458  8.57409   38.74557  1.000 18.07984 ? 613 LYS   B HG3  1 
ATOM   2134 H HD2  . LYS   A 1 135 ? 29.86836  7.38843   40.65726  1.000 19.10701 ? 613 LYS   B HD2  1 
ATOM   2135 H HD3  . LYS   A 1 135 ? 28.80028  8.50708   41.02229  1.000 19.10701 ? 613 LYS   B HD3  1 
ATOM   2136 H HE2  . LYS   A 1 135 ? 28.27817  6.48682   42.02045  1.000 24.03912 ? 613 LYS   B HE2  1 
ATOM   2137 H HE3  . LYS   A 1 135 ? 27.12845  6.94522   41.02374  1.000 24.03912 ? 613 LYS   B HE3  1 
ATOM   2138 H HZ1  . LYS   A 1 135 ? 27.88346  5.41380   39.53501  1.000 22.01806 ? 613 LYS   B HZ1  1 
ATOM   2139 H HZ2  . LYS   A 1 135 ? 28.97023  5.01811   40.40718  1.000 22.01806 ? 613 LYS   B HZ2  1 
ATOM   2140 H HZ3  . LYS   A 1 135 ? 27.60075  4.72646   40.77838  1.000 22.01806 ? 613 LYS   B HZ3  1 
ATOM   2141 N N    . HIS   A 1 136 ? 24.98773  8.90758   36.60471  1.000 13.46545 ? 614 HIS   B N    1 
ATOM   2142 C CA   . HIS   A 1 136 ? 23.65541  9.29649   36.15821  1.000 13.42842 ? 614 HIS   B CA   1 
ATOM   2143 C C    . HIS   A 1 136 ? 22.59041  8.32309   36.67224  1.000 14.25949 ? 614 HIS   B C    1 
ATOM   2144 O O    . HIS   A 1 136 ? 22.72614  7.09764   36.53787  1.000 14.76542 ? 614 HIS   B O    1 
ATOM   2145 C CB   . HIS   A 1 136 ? 23.63199  9.35016   34.64607  1.000 13.58435 ? 614 HIS   B CB   1 
ATOM   2146 C CG   . HIS   A 1 136 ? 24.70451  10.21272  34.06202  1.000 15.76974 ? 614 HIS   B CG   1 
ATOM   2147 N ND1  . HIS   A 1 136 ? 26.01064  9.78478   33.92799  1.000 16.62808 ? 614 HIS   B ND1  1 
ATOM   2148 C CD2  . HIS   A 1 136 ? 24.67824  11.50055  33.65320  1.000 16.80599 ? 614 HIS   B CD2  1 
ATOM   2149 C CE1  . HIS   A 1 136 ? 26.73206  10.78281  33.43955  1.000 16.49577 ? 614 HIS   B CE1  1 
ATOM   2150 N NE2  . HIS   A 1 136 ? 25.93379  11.81614  33.23433  1.000 18.18221 ? 614 HIS   B NE2  1 
ATOM   2151 H H    . HIS   A 1 136 ? 25.17235  8.07876   36.46846  1.000 16.11255 ? 614 HIS   B H    1 
ATOM   2152 H HA   . HIS   A 1 136 ? 23.43027  10.16339  36.53064  1.000 16.06811 ? 614 HIS   B HA   1 
ATOM   2153 H HB2  . HIS   A 1 136 ? 23.75160  8.45213   34.29947  1.000 16.25523 ? 614 HIS   B HB2  1 
ATOM   2154 H HB3  . HIS   A 1 136 ? 22.77619  9.70530   34.35905  1.000 16.25523 ? 614 HIS   B HB3  1 
ATOM   2155 H HD2  . HIS   A 1 136 ? 23.93970  12.06574  33.65738  1.000 20.12121 ? 614 HIS   B HD2  1 
ATOM   2156 H HE1  . HIS   A 1 136 ? 27.64614  10.76019  33.26968  1.000 19.74894 ? 614 HIS   B HE1  1 
ATOM   2157 H HE2  . HIS   A 1 136 ? 26.17031  12.56821  32.89075  1.000 21.77267 ? 614 HIS   B HE2  1 
ATOM   2158 N N    . MET   A 1 137 ? 21.54510  8.86993   37.27343  1.000 13.11478 ? 615 MET   B N    1 
ATOM   2159 C CA   . MET   A 1 137 ? 20.47039  8.05624   37.83198  1.000 14.33999 ? 615 MET   B CA   1 
ATOM   2160 C C    . MET   A 1 137 ? 19.14805  8.70981   37.48714  1.000 14.56198 ? 615 MET   B C    1 
ATOM   2161 O O    . MET   A 1 137 ? 18.97047  9.89425   37.75760  1.000 14.31720 ? 615 MET   B O    1 
ATOM   2162 C CB   . MET   A 1 137 ? 20.62030  7.94787   39.35207  1.000 15.99636 ? 615 MET   B CB   1 
ATOM   2163 C CG   . MET   A 1 137 ? 19.61259  7.16527   40.03884  1.000 18.38563 ? 615 MET   B CG   1 
ATOM   2164 S SD   . MET   A 1 137 ? 19.80483  7.29806   41.80516  1.000 15.55312 ? 615 MET   B SD   1 
ATOM   2165 C CE   . MET   A 1 137 ? 21.48535  6.65196   42.04353  1.000 18.00802 ? 615 MET   B CE   1 
ATOM   2166 H H    . MET   A 1 137 ? 21.43203  9.71669   37.37255  1.000 15.69175 ? 615 MET   B H    1 
ATOM   2167 H HA   . MET   A 1 137 ? 20.49582  7.16301   37.45463  1.000 17.16201 ? 615 MET   B HA   1 
ATOM   2168 H HB2  . MET   A 1 137 ? 21.47897  7.53905   39.54297  1.000 19.14965 ? 615 MET   B HB2  1 
ATOM   2169 H HB3  . MET   A 1 137 ? 20.58924  8.84332   39.72370  1.000 19.14965 ? 615 MET   B HB3  1 
ATOM   2170 H HG2  . MET   A 1 137 ? 18.73089  7.49104   39.79928  1.000 22.01677 ? 615 MET   B HG2  1 
ATOM   2171 H HG3  . MET   A 1 137 ? 19.70094  6.23235   39.78833  1.000 22.01677 ? 615 MET   B HG3  1 
ATOM   2172 H HE1  . MET   A 1 137 ? 21.61284  6.44206   42.98192  1.000 21.56364 ? 615 MET   B HE1  1 
ATOM   2173 H HE2  . MET   A 1 137 ? 21.59468  5.85089   41.50758  1.000 21.56364 ? 615 MET   B HE2  1 
ATOM   2174 H HE3  . MET   A 1 137 ? 22.12519  7.32588   41.76542  1.000 21.56364 ? 615 MET   B HE3  1 
ATOM   2175 N N    . TYR   A 1 138 ? 18.22816  7.93312   36.91462  1.000 12.86401 ? 616 TYR   B N    1 
ATOM   2176 C CA   . TYR   A 1 138 ? 16.88079  8.38261   36.68605  1.000 11.70842 ? 616 TYR   B CA   1 
ATOM   2177 C C    . TYR   A 1 138 ? 16.02104  8.14815   37.91622  1.000 13.75675 ? 616 TYR   B C    1 
ATOM   2178 O O    . TYR   A 1 138 ? 16.18858  7.17605   38.65747  1.000 14.03076 ? 616 TYR   B O    1 
ATOM   2179 C CB   . TYR   A 1 138 ? 16.26815  7.63371   35.48842  1.000 12.06504 ? 616 TYR   B CB   1 
ATOM   2180 C CG   . TYR   A 1 138 ? 16.87363  8.03168   34.17624  1.000 14.23425 ? 616 TYR   B CG   1 
ATOM   2181 C CD1  . TYR   A 1 138 ? 16.39970  9.12676   33.48215  1.000 12.29433 ? 616 TYR   B CD1  1 
ATOM   2182 C CD2  . TYR   A 1 138 ? 17.93138  7.32948   33.62655  1.000 11.40227 ? 616 TYR   B CD2  1 
ATOM   2183 C CE1  . TYR   A 1 138 ? 16.93560  9.47247   32.29693  1.000 12.70702 ? 616 TYR   B CE1  1 
ATOM   2184 C CE2  . TYR   A 1 138 ? 18.48715  7.68682   32.44302  1.000 14.79384 ? 616 TYR   B CE2  1 
ATOM   2185 C CZ   . TYR   A 1 138 ? 17.99971  8.79889   31.77100  1.000 13.05601 ? 616 TYR   B CZ   1 
ATOM   2186 O OH   . TYR   A 1 138 ? 18.54066  9.12989   30.56674  1.000 15.32864 ? 616 TYR   B OH   1 
ATOM   2187 H H    . TYR   A 1 138 ? 18.37466  7.12840   36.64897  1.000 15.39083 ? 616 TYR   B H    1 
ATOM   2188 H HA   . TYR   A 1 138 ? 16.88733  9.33348   36.49449  1.000 14.00411 ? 616 TYR   B HA   1 
ATOM   2189 H HB2  . TYR   A 1 138 ? 16.40990  6.68145   35.60681  1.000 14.43207 ? 616 TYR   B HB2  1 
ATOM   2190 H HB3  . TYR   A 1 138 ? 15.31807  7.82544   35.44997  1.000 14.43207 ? 616 TYR   B HB3  1 
ATOM   2191 H HD1  . TYR   A 1 138 ? 15.70322  9.63063   33.83701  1.000 14.70721 ? 616 TYR   B HD1  1 
ATOM   2192 H HD2  . TYR   A 1 138 ? 18.27023  6.59243   34.08134  1.000 13.63674 ? 616 TYR   B HD2  1 
ATOM   2193 H HE1  . TYR   A 1 138 ? 16.57232  10.18699  31.82535  1.000 15.20244 ? 616 TYR   B HE1  1 
ATOM   2194 H HE2  . TYR   A 1 138 ? 19.18818  7.19164   32.08488  1.000 17.70662 ? 616 TYR   B HE2  1 
ATOM   2195 H HH   . TYR   A 1 138 ? 18.11220  9.76619   30.22447  1.000 18.34838 ? 616 TYR   B HH   1 
ATOM   2196 N N    . VAL   A 1 139 ? 15.06523  9.05262   38.11131  1.000 11.63485 ? 617 VAL   B N    1 
ATOM   2197 C CA   . VAL   A 1 139 ? 13.94548  8.87898   39.01786  1.000 12.71024 ? 617 VAL   B CA   1 
ATOM   2198 C C    . VAL   A 1 139 ? 12.73948  8.61091   38.13526  1.000 12.12428 ? 617 VAL   B C    1 
ATOM   2199 O O    . VAL   A 1 139 ? 12.47154  9.37140   37.18910  1.000 13.21804 ? 617 VAL   B O    1 
ATOM   2200 C CB   . VAL   A 1 139 ? 13.71485  10.09983  39.91456  1.000 13.88777 ? 617 VAL   B CB   1 
ATOM   2201 C CG1  . VAL   A 1 139 ? 12.61417  9.78768   40.95601  1.000 17.48200 ? 617 VAL   B CG1  1 
ATOM   2202 C CG2  . VAL   A 1 139 ? 15.00141  10.49233  40.60337  1.000 14.08634 ? 617 VAL   B CG2  1 
ATOM   2203 H H    . VAL   A 1 139 ? 15.04698  9.81158   37.70728  1.000 13.91584 ? 617 VAL   B H    1 
ATOM   2204 H HA   . VAL   A 1 139 ? 14.10859  8.13078   39.61325  1.000 15.20630 ? 617 VAL   B HA   1 
ATOM   2205 H HB   . VAL   A 1 139 ? 13.42173  10.84837  39.37172  1.000 16.61934 ? 617 VAL   B HB   1 
ATOM   2206 H HG11 . VAL   A 1 139 ? 12.52550  10.54319  41.55789  1.000 20.93242 ? 617 VAL   B HG11 1 
ATOM   2207 H HG12 . VAL   A 1 139 ? 11.77588  9.63349   40.49297  1.000 20.93242 ? 617 VAL   B HG12 1 
ATOM   2208 H HG13 . VAL   A 1 139 ? 12.86709  8.99521   41.45493  1.000 20.93242 ? 617 VAL   B HG13 1 
ATOM   2209 H HG21 . VAL   A 1 139 ? 14.81397  11.19374  41.24664  1.000 16.85762 ? 617 VAL   B HG21 1 
ATOM   2210 H HG22 . VAL   A 1 139 ? 15.36623  9.71639   41.05695  1.000 16.85762 ? 617 VAL   B HG22 1 
ATOM   2211 H HG23 . VAL   A 1 139 ? 15.63060  10.81292  39.93836  1.000 16.85762 ? 617 VAL   B HG23 1 
ATOM   2212 N N    . VAL   A 1 140 ? 12.04060  7.49912   38.40832  1.000 11.51600 ? 618 VAL   B N    1 
ATOM   2213 C CA   . VAL   A 1 140 ? 11.13113  6.91136   37.42705  1.000 12.49150 ? 618 VAL   B CA   1 
ATOM   2214 C C    . VAL   A 1 140 ? 9.77406   6.61085   38.05452  1.000 12.67272 ? 618 VAL   B C    1 
ATOM   2215 O O    . VAL   A 1 140 ? 9.69873   6.01788   39.12557  1.000 12.61259 ? 618 VAL   B O    1 
ATOM   2216 C CB   . VAL   A 1 140 ? 11.77454  5.63605   36.83441  1.000 12.76324 ? 618 VAL   B CB   1 
ATOM   2217 C CG1  . VAL   A 1 140 ? 10.89406  5.06749   35.70316  1.000 12.97620 ? 618 VAL   B CG1  1 
ATOM   2218 C CG2  . VAL   A 1 140 ? 13.19317  5.90840   36.41699  1.000 12.06327 ? 618 VAL   B CG2  1 
ATOM   2219 H H    . VAL   A 1 140 ? 12.08029  7.07290   39.15422  1.000 13.77321 ? 618 VAL   B H    1 
ATOM   2220 H HA   . VAL   A 1 140 ? 10.94762  7.55495   36.72490  1.000 14.94381 ? 618 VAL   B HA   1 
ATOM   2221 H HB   . VAL   A 1 140 ? 11.82462  4.94173   37.50992  1.000 15.26990 ? 618 VAL   B HB   1 
ATOM   2222 H HG11 . VAL   A 1 140 ? 11.36001  4.32869   35.28130  1.000 15.52545 ? 618 VAL   B HG11 1 
ATOM   2223 H HG12 . VAL   A 1 140 ? 10.05598  4.75765   36.08067  1.000 15.52545 ? 618 VAL   B HG12 1 
ATOM   2224 H HG13 . VAL   A 1 140 ? 10.72527  5.76684   35.05253  1.000 15.52545 ? 618 VAL   B HG13 1 
ATOM   2225 H HG21 . VAL   A 1 140 ? 13.52158  5.15397   35.90329  1.000 14.42994 ? 618 VAL   B HG21 1 
ATOM   2226 H HG22 . VAL   A 1 140 ? 13.21393  6.71219   35.87441  1.000 14.42994 ? 618 VAL   B HG22 1 
ATOM   2227 H HG23 . VAL   A 1 140 ? 13.73784  6.03064   37.21027  1.000 14.42994 ? 618 VAL   B HG23 1 
ATOM   2228 N N    . ARG   A 1 141 ? 8.69199   7.00067   37.36553  1.000 12.08679 ? 619 ARG   B N    1 
ATOM   2229 C CA   . ARG   A 1 141 ? 7.36896   6.50998   37.72254  1.000 12.15265 ? 619 ARG   B CA   1 
ATOM   2230 C C    . ARG   A 1 141 ? 7.23062   5.12176   37.09230  1.000 12.57764 ? 619 ARG   B C    1 
ATOM   2231 O O    . ARG   A 1 141 ? 7.38008   4.97520   35.87248  1.000 13.64951 ? 619 ARG   B O    1 
ATOM   2232 C CB   . ARG   A 1 141 ? 6.27120   7.44027   37.23293  1.000 13.91212 ? 619 ARG   B CB   1 
ATOM   2233 C CG   . ARG   A 1 141 ? 6.27707   8.80344   37.89616  1.000 13.68739 ? 619 ARG   B CG   1 
ATOM   2234 C CD   . ARG   A 1 141 ? 5.05877   9.60596   37.54016  1.000 15.77189 ? 619 ARG   B CD   1 
ATOM   2235 N NE   . ARG   A 1 141 ? 5.23623   11.00927  37.90593  1.000 16.23311 ? 619 ARG   B NE   1 
ATOM   2236 C CZ   . ARG   A 1 141 ? 4.25802   11.91691  37.83878  1.000 16.18816 ? 619 ARG   B CZ   1 
ATOM   2237 N NH1  . ARG   A 1 141 ? 3.00469   11.57207  37.61756  1.000 16.84313 ? 619 ARG   B NH1  1 
ATOM   2238 N NH2  . ARG   A 1 141 ? 4.54093   13.19610  38.07482  1.000 17.05186 ? 619 ARG   B NH2  1 
ATOM   2239 H H    . ARG   A 1 141 ? 8.70553   7.54174   36.69720  1.000 14.45817 ? 619 ARG   B H    1 
ATOM   2240 H HA   . ARG   A 1 141 ? 7.27374   6.46161   38.68664  1.000 14.53720 ? 619 ARG   B HA   1 
ATOM   2241 H HB2  . ARG   A 1 141 ? 6.38119   7.57581   36.27877  1.000 16.64856 ? 619 ARG   B HB2  1 
ATOM   2242 H HB3  . ARG   A 1 141 ? 5.41157   7.02836   37.41259  1.000 16.64856 ? 619 ARG   B HB3  1 
ATOM   2243 H HG2  . ARG   A 1 141 ? 6.29445   8.69017   38.85937  1.000 16.37889 ? 619 ARG   B HG2  1 
ATOM   2244 H HG3  . ARG   A 1 141 ? 7.06025   9.29671   37.60594  1.000 16.37889 ? 619 ARG   B HG3  1 
ATOM   2245 H HD2  . ARG   A 1 141 ? 4.90506   9.55407   36.58382  1.000 18.88028 ? 619 ARG   B HD2  1 
ATOM   2246 H HD3  . ARG   A 1 141 ? 4.29046   9.25771   38.01904  1.000 18.88028 ? 619 ARG   B HD3  1 
ATOM   2247 H HE   . ARG   A 1 141 ? 6.01087   11.26446  38.17873  1.000 19.43375 ? 619 ARG   B HE   1 
ATOM   2248 H HH11 . ARG   A 1 141 ? 2.79882   10.74377  37.51204  1.000 20.16577 ? 619 ARG   B HH11 1 
ATOM   2249 H HH12 . ARG   A 1 141 ? 2.39312   12.17547  37.57880  1.000 20.16577 ? 619 ARG   B HH12 1 
ATOM   2250 H HH21 . ARG   A 1 141 ? 5.34569   13.42998  38.26785  1.000 20.41625 ? 619 ARG   B HH21 1 
ATOM   2251 H HH22 . ARG   A 1 141 ? 3.91894   13.78863  38.03429  1.000 20.41625 ? 619 ARG   B HH22 1 
ATOM   2252 N N    . VAL   A 1 142 ? 6.97052   4.11527   37.92097  1.000 11.67610 ? 620 VAL   B N    1 
ATOM   2253 C CA   . VAL   A 1 142 ? 6.92215   2.72731   37.50355  1.000 11.72658 ? 620 VAL   B CA   1 
ATOM   2254 C C    . VAL   A 1 142 ? 5.57935   2.14755   37.89203  1.000 12.88120 ? 620 VAL   B C    1 
ATOM   2255 O O    . VAL   A 1 142 ? 5.14462   2.29822   39.03644  1.000 12.63280 ? 620 VAL   B O    1 
ATOM   2256 C CB   . VAL   A 1 142 ? 8.07083   1.90345   38.12174  1.000 12.60307 ? 620 VAL   B CB   1 
ATOM   2257 C CG1  . VAL   A 1 142 ? 8.03663   0.48830   37.58622  1.000 13.09819 ? 620 VAL   B CG1  1 
ATOM   2258 C CG2  . VAL   A 1 142 ? 9.41509   2.57122   37.79383  1.000 13.97853 ? 620 VAL   B CG2  1 
ATOM   2259 H H    . VAL   A 1 142 ? 6.81362   4.22053   38.75995  1.000 13.96533 ? 620 VAL   B H    1 
ATOM   2260 H HA   . VAL   A 1 142 ? 7.00019   2.68796   36.53750  1.000 14.02592 ? 620 VAL   B HA   1 
ATOM   2261 H HB   . VAL   A 1 142 ? 7.96879   1.86647   39.08565  1.000 15.07770 ? 620 VAL   B HB   1 
ATOM   2262 H HG11 . VAL   A 1 142 ? 8.84232   0.02561   37.86493  1.000 15.67184 ? 620 VAL   B HG11 1 
ATOM   2263 H HG12 . VAL   A 1 142 ? 7.25561   0.03528   37.94072  1.000 15.67184 ? 620 VAL   B HG12 1 
ATOM   2264 H HG13 . VAL   A 1 142 ? 7.99055   0.51815   36.61777  1.000 15.67184 ? 620 VAL   B HG13 1 
ATOM   2265 H HG21 . VAL   A 1 142 ? 10.13491  2.00979   38.12177  1.000 16.72825 ? 620 VAL   B HG21 1 
ATOM   2266 H HG22 . VAL   A 1 142 ? 9.48931   2.67628   36.83240  1.000 16.72825 ? 620 VAL   B HG22 1 
ATOM   2267 H HG23 . VAL   A 1 142 ? 9.44997   3.43937   38.22512  1.000 16.72825 ? 620 VAL   B HG23 1 
ATOM   2268 N N    . LEU   A 1 143 ? 4.91756   1.49908   36.92570  1.000 11.71809 ? 621 LEU   B N    1 
ATOM   2269 C CA   . LEU   A 1 143 ? 3.61549   0.87437   37.19342  1.000 13.03128 ? 621 LEU   B CA   1 
ATOM   2270 C C    . LEU   A 1 143 ? 3.88602   -0.53202  37.73708  1.000 11.94999 ? 621 LEU   B C    1 
ATOM   2271 O O    . LEU   A 1 143 ? 3.84358   -1.53424  37.01251  1.000 12.17153 ? 621 LEU   B O    1 
ATOM   2272 C CB   . LEU   A 1 143 ? 2.74084   0.86355   35.94952  1.000 12.67742 ? 621 LEU   B CB   1 
ATOM   2273 C CG   . LEU   A 1 143 ? 2.33857   2.27651   35.47202  1.000 12.47379 ? 621 LEU   B CG   1 
ATOM   2274 C CD1  . LEU   A 1 143 ? 1.72455   2.19031   34.06623  1.000 13.96437 ? 621 LEU   B CD1  1 
ATOM   2275 C CD2  . LEU   A 1 143 ? 1.38386   2.89114   36.45045  1.000 12.92164 ? 621 LEU   B CD2  1 
ATOM   2276 H H    . LEU   A 1 143 ? 5.19820   1.40853   36.11784  1.000 14.01572 ? 621 LEU   B H    1 
ATOM   2277 H HA   . LEU   A 1 143 ? 3.14021   1.38513   37.86732  1.000 15.59155 ? 621 LEU   B HA   1 
ATOM   2278 H HB2  . LEU   A 1 143 ? 3.22662   0.43204   35.22931  1.000 15.16692 ? 621 LEU   B HB2  1 
ATOM   2279 H HB3  . LEU   A 1 143 ? 1.92786   0.37109   36.14306  1.000 15.16692 ? 621 LEU   B HB3  1 
ATOM   2280 H HG   . LEU   A 1 143 ? 3.11839   2.85117   35.42152  1.000 14.92256 ? 621 LEU   B HG   1 
ATOM   2281 H HD11 . LEU   A 1 143 ? 1.47945   3.08200   33.77346  1.000 16.71126 ? 621 LEU   B HD11 1 
ATOM   2282 H HD12 . LEU   A 1 143 ? 2.37857   1.81077   33.45869  1.000 16.71126 ? 621 LEU   B HD12 1 
ATOM   2283 H HD13 . LEU   A 1 143 ? 0.93702   1.62501   34.09972  1.000 16.71126 ? 621 LEU   B HD13 1 
ATOM   2284 H HD21 . LEU   A 1 143 ? 1.04278   3.72041   36.08048  1.000 15.45998 ? 621 LEU   B HD21 1 
ATOM   2285 H HD22 . LEU   A 1 143 ? 0.65247   2.27385   36.60833  1.000 15.45998 ? 621 LEU   B HD22 1 
ATOM   2286 H HD23 . LEU   A 1 143 ? 1.85286   3.06766   37.28098  1.000 15.45998 ? 621 LEU   B HD23 1 
ATOM   2287 N N    . THR   A 1 144 ? 4.20185   -0.57892  39.04560  1.000 11.64409 ? 622 THR   B N    1 
ATOM   2288 C CA   . THR   A 1 144 ? 4.46393   -1.85656  39.71440  1.000 11.52311 ? 622 THR   B CA   1 
ATOM   2289 C C    . THR   A 1 144 ? 3.17204   -2.66404  39.88099  1.000 12.31713 ? 622 THR   B C    1 
ATOM   2290 O O    . THR   A 1 144 ? 3.21671   -3.91006  39.94243  1.000 11.98314 ? 622 THR   B O    1 
ATOM   2291 C CB   . THR   A 1 144 ? 5.14176   -1.61986  41.05743  1.000 14.57462 ? 622 THR   B CB   1 
ATOM   2292 O OG1  . THR   A 1 144 ? 4.45282   -0.60866  41.80088  1.000 14.68232 ? 622 THR   B OG1  1 
ATOM   2293 C CG2  . THR   A 1 144 ? 6.57015   -1.14840  40.84002  1.000 14.15554 ? 622 THR   B CG2  1 
ATOM   2294 H H    . THR   A 1 144 ? 4.26889   0.10842   39.55811  1.000 13.92693 ? 622 THR   B H    1 
ATOM   2295 H HA   . THR   A 1 144 ? 5.07644   -2.38162  39.17585  1.000 13.78174 ? 622 THR   B HA   1 
ATOM   2296 H HB   . THR   A 1 144 ? 5.13620   -2.45014  41.55894  1.000 17.44356 ? 622 THR   B HB   1 
ATOM   2297 H HG1  . THR   A 1 144 ? 3.66081   -0.84804  41.94582  1.000 17.57280 ? 622 THR   B HG1  1 
ATOM   2298 H HG21 . THR   A 1 144 ? 7.03405   -1.09244  41.69006  1.000 16.94067 ? 622 THR   B HG21 1 
ATOM   2299 H HG22 . THR   A 1 144 ? 7.04120   -1.77135  40.26474  1.000 16.94067 ? 622 THR   B HG22 1 
ATOM   2300 H HG23 . THR   A 1 144 ? 6.57060   -0.27267  40.42289  1.000 16.94067 ? 622 THR   B HG23 1 
ATOM   2301 N N    . GLY   A 1 145 ? 2.03853   -1.99175  39.97812  1.000 13.30427 ? 623 GLY   B N    1 
ATOM   2302 C CA   . GLY   A 1 145 ? 0.76257   -2.69822  40.06514  1.000 13.87168 ? 623 GLY   B CA   1 
ATOM   2303 C C    . GLY   A 1 145 ? 0.75264   -3.75819  41.15269  1.000 14.73490 ? 623 GLY   B C    1 
ATOM   2304 O O    . GLY   A 1 145 ? 1.14270   -3.51859  42.30126  1.000 14.80042 ? 623 GLY   B O    1 
ATOM   2305 H H    . GLY   A 1 145 ? 1.97430   -1.13434  39.99611  1.000 15.91913 ? 623 GLY   B H    1 
ATOM   2306 H HA2  . GLY   A 1 145 ? 0.05617   -2.06118  40.25506  1.000 16.60003 ? 623 GLY   B HA2  1 
ATOM   2307 H HA3  . GLY   A 1 145 ? 0.57779   -3.13114  39.21701  1.000 16.60003 ? 623 GLY   B HA3  1 
ATOM   2308 N N    . VAL   A 1 146 ? 0.23289   -4.94079  40.80859  1.000 12.92493 ? 624 VAL   B N    1 
ATOM   2309 C CA   . VAL   A 1 146 ? 0.17795   -6.07397  41.70592  1.000 13.61412 ? 624 VAL   B CA   1 
ATOM   2310 C C    . VAL   A 1 146 ? 1.36060   -6.95702  41.33985  1.000 14.54138 ? 624 VAL   B C    1 
ATOM   2311 O O    . VAL   A 1 146 ? 1.52945   -7.32418  40.17314  1.000 14.86512 ? 624 VAL   B O    1 
ATOM   2312 C CB   . VAL   A 1 146 ? -1.15353  -6.83699  41.55806  1.000 15.44865 ? 624 VAL   B CB   1 
ATOM   2313 C CG1  . VAL   A 1 146 ? -1.15944  -8.01471  42.49069  1.000 17.86532 ? 624 VAL   B CG1  1 
ATOM   2314 C CG2  . VAL   A 1 146 ? -2.34413  -5.93012  41.84009  1.000 19.67931 ? 624 VAL   B CG2  1 
ATOM   2315 H H    . VAL   A 1 146 ? -0.10201  -5.10564  40.03382  1.000 15.46393 ? 624 VAL   B H    1 
ATOM   2316 H HA   . VAL   A 1 146 ? 0.24984   -5.79019  42.63069  1.000 16.29096 ? 624 VAL   B HA   1 
ATOM   2317 H HB   . VAL   A 1 146 ? -1.23843  -7.15071  40.64413  1.000 18.49240 ? 624 VAL   B HB   1 
ATOM   2318 H HG11 . VAL   A 1 146 ? -2.04966  -8.39957  42.50776  1.000 21.39240 ? 624 VAL   B HG11 1 
ATOM   2319 H HG12 . VAL   A 1 146 ? -0.52086  -8.67220  42.17316  1.000 21.39240 ? 624 VAL   B HG12 1 
ATOM   2320 H HG13 . VAL   A 1 146 ? -0.91152  -7.71508  43.37932  1.000 21.39240 ? 624 VAL   B HG13 1 
ATOM   2321 H HG21 . VAL   A 1 146 ? -3.14169  -6.47482  41.93000  1.000 23.56919 ? 624 VAL   B HG21 1 
ATOM   2322 H HG22 . VAL   A 1 146 ? -2.18194  -5.44273  42.66292  1.000 23.56919 ? 624 VAL   B HG22 1 
ATOM   2323 H HG23 . VAL   A 1 146 ? -2.44938  -5.30866  41.10279  1.000 23.56919 ? 624 VAL   B HG23 1 
ATOM   2324 N N    . PHE   A 1 147 ? 2.18813   -7.28355  42.31817  1.000 15.84756 ? 625 PHE   B N    1 
ATOM   2325 C CA   . PHE   A 1 147 ? 3.46994   -7.93568  42.05740  1.000 13.66090 ? 625 PHE   B CA   1 
ATOM   2326 C C    . PHE   A 1 147 ? 3.66771   -9.15837  42.95455  1.000 16.12835 ? 625 PHE   B C    1 
ATOM   2327 O O    . PHE   A 1 147 ? 2.97510   -9.35246  43.95827  1.000 15.93824 ? 625 PHE   B O    1 
ATOM   2328 C CB   . PHE   A 1 147 ? 4.61948   -6.94941  42.24161  1.000 15.64804 ? 625 PHE   B CB   1 
ATOM   2329 C CG   . PHE   A 1 147 ? 4.55725   -6.19124  43.53367  1.000 15.41012 ? 625 PHE   B CG   1 
ATOM   2330 C CD1  . PHE   A 1 147 ? 5.15624   -6.70262  44.67837  1.000 16.94959 ? 625 PHE   B CD1  1 
ATOM   2331 C CD2  . PHE   A 1 147 ? 3.95755   -4.94846  43.59300  1.000 17.65967 ? 625 PHE   B CD2  1 
ATOM   2332 C CE1  . PHE   A 1 147 ? 5.11129   -5.98716  45.87213  1.000 19.61101 ? 625 PHE   B CE1  1 
ATOM   2333 C CE2  . PHE   A 1 147 ? 3.92593   -4.24487  44.78430  1.000 17.64354 ? 625 PHE   B CE2  1 
ATOM   2334 C CZ   . PHE   A 1 147 ? 4.47579   -4.78772  45.91972  1.000 19.22752 ? 625 PHE   B CZ   1 
ATOM   2335 H H    . PHE   A 1 147 ? 2.03224   -7.13820  43.15134  1.000 18.97108 ? 625 PHE   B H    1 
ATOM   2336 H HA   . PHE   A 1 147 ? 3.47458   -8.26654  41.14558  1.000 16.34710 ? 625 PHE   B HA   1 
ATOM   2337 H HB2  . PHE   A 1 147 ? 5.45693   -7.43857  42.22442  1.000 18.73166 ? 625 PHE   B HB2  1 
ATOM   2338 H HB3  . PHE   A 1 147 ? 4.59711   -6.30439  41.51749  1.000 18.73166 ? 625 PHE   B HB3  1 
ATOM   2339 H HD1  . PHE   A 1 147 ? 5.58858   -7.52542  44.64715  1.000 20.29352 ? 625 PHE   B HD1  1 
ATOM   2340 H HD2  . PHE   A 1 147 ? 3.57331   -4.58288  42.82905  1.000 21.14561 ? 625 PHE   B HD2  1 
ATOM   2341 H HE1  . PHE   A 1 147 ? 5.51596   -6.33022  46.63597  1.000 23.48723 ? 625 PHE   B HE1  1 
ATOM   2342 H HE2  . PHE   A 1 147 ? 3.53172   -3.40314  44.81606  1.000 21.12627 ? 625 PHE   B HE2  1 
ATOM   2343 H HZ   . PHE   A 1 147 ? 4.41253   -4.33064  46.72717  1.000 23.02704 ? 625 PHE   B HZ   1 
ATOM   2344 N N    . THR   A 1 148 ? 4.59429   -10.00152 42.53061  1.000 14.58123 ? 626 THR   B N    1 
ATOM   2345 C CA   . THR   A 1 148 ? 4.98334   -11.19752 43.26139  1.000 16.86064 ? 626 THR   B CA   1 
ATOM   2346 C C    . THR   A 1 148 ? 6.49883   -11.36284 43.16857  1.000 15.25340 ? 626 THR   B C    1 
ATOM   2347 O O    . THR   A 1 148 ? 7.18903   -10.64308 42.44330  1.000 14.68191 ? 626 THR   B O    1 
ATOM   2348 C CB   . THR   A 1 148 ? 4.23543   -12.41987 42.71050  1.000 18.13166 ? 626 THR   B CB   1 
ATOM   2349 O OG1  . THR   A 1 148 ? 4.40484   -13.53272 43.59024  1.000 18.89875 ? 626 THR   B OG1  1 
ATOM   2350 C CG2  . THR   A 1 148 ? 4.74667   -12.80382 41.31438  1.000 16.56320 ? 626 THR   B CG2  1 
ATOM   2351 H H    . THR   A 1 148 ? 5.02887   -9.90007  41.79546  1.000 17.45149 ? 626 THR   B H    1 
ATOM   2352 H HA   . THR   A 1 148 ? 4.76763   -11.11044 44.20308  1.000 20.18678 ? 626 THR   B HA   1 
ATOM   2353 H HB   . THR   A 1 148 ? 3.29342   -12.19994 42.63885  1.000 21.71201 ? 626 THR   B HB   1 
ATOM   2354 H HG1  . THR   A 1 148 ? 5.18334   -13.83990 43.51831  1.000 22.63252 ? 626 THR   B HG1  1 
ATOM   2355 H HG21 . THR   A 1 148 ? 4.13801   -13.43547 40.90032  1.000 19.82985 ? 626 THR   B HG21 1 
ATOM   2356 H HG22 . THR   A 1 148 ? 4.80898   -12.01378 40.75504  1.000 19.82985 ? 626 THR   B HG22 1 
ATOM   2357 H HG23 . THR   A 1 148 ? 5.62437   -13.21105 41.38288  1.000 19.82985 ? 626 THR   B HG23 1 
ATOM   2358 N N    . LYS   A 1 149 ? 7.03049   -12.31424 43.92495  1.000 15.19194 ? 627 LYS   B N    1 
ATOM   2359 C CA   . LYS   A 1 149 ? 8.46700   -12.56305 43.85032  1.000 16.16443 ? 627 LYS   B CA   1 
ATOM   2360 C C    . LYS   A 1 149 ? 8.81176   -13.12986 42.48003  1.000 15.47212 ? 627 LYS   B C    1 
ATOM   2361 O O    . LYS   A 1 149 ? 8.25450   -14.14599 42.05387  1.000 16.69328 ? 627 LYS   B O    1 
ATOM   2362 C CB   . LYS   A 1 149 ? 8.90385   -13.50222 44.96162  1.000 18.35303 ? 627 LYS   B CB   1 
ATOM   2363 C CG   . LYS   A 1 149 ? 10.40656  -13.73313 45.01912  1.000 18.19374 ? 627 LYS   B CG   1 
ATOM   2364 C CD   . LYS   A 1 149 ? 10.77930  -14.63694 46.18560  1.000 24.81809 ? 627 LYS   B CD   1 
ATOM   2365 C CE   . LYS   A 1 149 ? 12.30395  -14.79387 46.30717  1.000 33.27193 ? 627 LYS   B CE   1 
ATOM   2366 N NZ   . LYS   A 1 149 ? 12.69516  -15.46698 47.57297  1.000 43.39663 ? 627 LYS   B NZ   1 
ATOM   2367 H H    . LYS   A 1 149 ? 6.59672   -12.81521 44.47310  1.000 18.18434 ? 627 LYS   B H    1 
ATOM   2368 H HA   . LYS   A 1 149 ? 8.95571   -11.73373 43.96990  1.000 19.35133 ? 627 LYS   B HA   1 
ATOM   2369 H HB2  . LYS   A 1 149 ? 8.63001   -13.12588 45.81266  1.000 21.97765 ? 627 LYS   B HB2  1 
ATOM   2370 H HB3  . LYS   A 1 149 ? 8.47760   -14.36308 44.82701  1.000 21.97765 ? 627 LYS   B HB3  1 
ATOM   2371 H HG2  . LYS   A 1 149 ? 10.69946  -14.15717 44.19735  1.000 21.78650 ? 627 LYS   B HG2  1 
ATOM   2372 H HG3  . LYS   A 1 149 ? 10.85944  -12.88300 45.13347  1.000 21.78650 ? 627 LYS   B HG3  1 
ATOM   2373 H HD2  . LYS   A 1 149 ? 10.44508  -14.25184 47.01076  1.000 29.73572 ? 627 LYS   B HD2  1 
ATOM   2374 H HD3  . LYS   A 1 149 ? 10.39173  -15.51554 46.04867  1.000 29.73572 ? 627 LYS   B HD3  1 
ATOM   2375 H HE2  . LYS   A 1 149 ? 12.62987  -15.32865 45.56644  1.000 39.88033 ? 627 LYS   B HE2  1 
ATOM   2376 H HE3  . LYS   A 1 149 ? 12.71749  -13.91661 46.29024  1.000 39.88033 ? 627 LYS   B HE3  1 
ATOM   2377 H HZ1  . LYS   A 1 149 ? 13.58064  -15.54632 47.61447  1.000 52.02998 ? 627 LYS   B HZ1  1 
ATOM   2378 H HZ2  . LYS   A 1 149 ? 12.41487  -14.99039 48.27040  1.000 52.02998 ? 627 LYS   B HZ2  1 
ATOM   2379 H HZ3  . LYS   A 1 149 ? 12.33037  -16.27785 47.61188  1.000 52.02998 ? 627 LYS   B HZ3  1 
ATOM   2380 N N    . GLY   A 1 150 ? 9.79331   -12.51624 41.80725  1.000 14.09818 ? 628 GLY   B N    1 
ATOM   2381 C CA   . GLY   A 1 150 ? 10.16167  -12.96308 40.48913  1.000 14.86690 ? 628 GLY   B CA   1 
ATOM   2382 C C    . GLY   A 1 150 ? 11.10569  -14.17515 40.51507  1.000 15.98796 ? 628 GLY   B C    1 
ATOM   2383 O O    . GLY   A 1 150 ? 11.42833  -14.72273 41.56535  1.000 15.66992 ? 628 GLY   B O    1 
ATOM   2384 H H    . GLY   A 1 150 ? 10.24725  -11.84773 42.10159  1.000 16.87183 ? 628 GLY   B H    1 
ATOM   2385 H HA2  . GLY   A 1 150 ? 9.36134   -13.21123 40.00048  1.000 17.79429 ? 628 GLY   B HA2  1 
ATOM   2386 H HA3  . GLY   A 1 150 ? 10.60709  -12.24057 40.01957  1.000 17.79429 ? 628 GLY   B HA3  1 
ATOM   2387 N N    . ARG   A 1 151 ? 11.52382  -14.58333 39.32263  1.000 15.85759 ? 629 ARG   B N    1 
ATOM   2388 C CA   A ARG   A 1 151 ? 12.44663  -15.69994 39.13059  0.563 16.87723 ? 629 ARG   B CA   1 
ATOM   2389 C CA   B ARG   A 1 151 ? 12.48386  -15.66538 39.16106  0.437 17.02747 ? 629 ARG   B CA   1 
ATOM   2390 C C    . ARG   A 1 151 ? 13.25139  -15.42892 37.87566  1.000 15.79610 ? 629 ARG   B C    1 
ATOM   2391 O O    . ARG   A 1 151 ? 12.74095  -14.82041 36.93626  1.000 14.50453 ? 629 ARG   B O    1 
ATOM   2392 C CB   A ARG   A 1 151 ? 11.71314  -17.04177 39.00777  0.563 17.76828 ? 629 ARG   B CB   1 
ATOM   2393 C CB   B ARG   A 1 151 ? 11.82350  -17.04813 39.14155  0.437 17.74738 ? 629 ARG   B CB   1 
ATOM   2394 C CG   A ARG   A 1 151 ? 10.97279  -17.42551 40.27381  0.563 18.47107 ? 629 ARG   B CG   1 
ATOM   2395 C CG   B ARG   A 1 151 ? 10.96782  -17.34114 37.94439  0.437 17.59305 ? 629 ARG   B CG   1 
ATOM   2396 C CD   A ARG   A 1 151 ? 10.28299  -18.79273 40.16470  0.563 20.28017 ? 629 ARG   B CD   1 
ATOM   2397 C CD   B ARG   A 1 151 ? 10.56314  -18.82906 37.91764  0.437 21.49317 ? 629 ARG   B CD   1 
ATOM   2398 N NE   A ARG   A 1 151 ? 9.49378   -19.07715 41.35740  0.563 17.25642 ? 629 ARG   B NE   1 
ATOM   2399 N NE   B ARG   A 1 151 ? 9.47204   -19.08571 36.98323  0.437 24.42520 ? 629 ARG   B NE   1 
ATOM   2400 C CZ   A ARG   A 1 151 ? 9.04972   -20.28183 41.69482  0.563 19.44539 ? 629 ARG   B CZ   1 
ATOM   2401 C CZ   B ARG   A 1 151 ? 9.61355   -19.17031 35.67160  0.437 22.85886 ? 629 ARG   B CZ   1 
ATOM   2402 N NH1  A ARG   A 1 151 ? 9.29278   -21.34646 40.94504  0.563 21.50181 ? 629 ARG   B NH1  1 
ATOM   2403 N NH1  B ARG   A 1 151 ? 10.78337  -18.97833 35.09861  0.437 23.33279 ? 629 ARG   B NH1  1 
ATOM   2404 N NH2  A ARG   A 1 151 ? 8.34263   -20.42107 42.81278  0.563 21.53256 ? 629 ARG   B NH2  1 
ATOM   2405 N NH2  B ARG   A 1 151 ? 8.54923   -19.44283 34.92212  0.437 20.87832 ? 629 ARG   B NH2  1 
ATOM   2406 H H    A ARG   A 1 151 ? 11.28034  -14.21882 38.58273  0.563 18.98312 ? 629 ARG   B H    1 
ATOM   2407 H H    B ARG   A 1 151 ? 11.26081  -14.24256 38.57812  0.437 18.98312 ? 629 ARG   B H    1 
ATOM   2408 H HA   A ARG   A 1 151 ? 13.04758  -15.76350 39.88935  0.563 20.20669 ? 629 ARG   B HA   1 
ATOM   2409 H HA   B ARG   A 1 151 ? 13.10288  -15.65750 39.90782  0.437 20.38698 ? 629 ARG   B HA   1 
ATOM   2410 H HB2  A ARG   A 1 151 ? 11.06577  -16.98256 38.28783  0.563 21.27595 ? 629 ARG   B HB2  1 
ATOM   2411 H HB2  B ARG   A 1 151 ? 12.52266  -17.71999 39.16750  0.437 21.25087 ? 629 ARG   B HB2  1 
ATOM   2412 H HB3  A ARG   A 1 151 ? 12.36016  -17.73844 38.81566  0.563 21.27595 ? 629 ARG   B HB3  1 
ATOM   2413 H HB3  B ARG   A 1 151 ? 11.25839  -17.12692 39.92599  0.437 21.25087 ? 629 ARG   B HB3  1 
ATOM   2414 H HG2  A ARG   A 1 151 ? 11.60339  -17.46566 41.00976  0.563 22.11930 ? 629 ARG   B HG2  1 
ATOM   2415 H HG2  B ARG   A 1 151 ? 10.16184  -16.80273 37.98173  0.437 21.06567 ? 629 ARG   B HG2  1 
ATOM   2416 H HG3  A ARG   A 1 151 ? 10.29152  -16.75965 40.45660  0.563 22.11930 ? 629 ARG   B HG3  1 
ATOM   2417 H HG3  B ARG   A 1 151 ? 11.46302  -17.14139 37.13459  0.437 21.06567 ? 629 ARG   B HG3  1 
ATOM   2418 H HD2  A ARG   A 1 151 ? 9.69052   -18.79513 39.39667  0.563 24.29022 ? 629 ARG   B HD2  1 
ATOM   2419 H HD2  B ARG   A 1 151 ? 11.32638  -19.36198 37.64494  0.437 25.74582 ? 629 ARG   B HD2  1 
ATOM   2420 H HD3  A ARG   A 1 151 ? 10.95423  -19.48628 40.06805  0.563 24.29022 ? 629 ARG   B HD3  1 
ATOM   2421 H HD3  B ARG   A 1 151 ? 10.27166  -19.09595 38.80347  0.437 25.74582 ? 629 ARG   B HD3  1 
ATOM   2422 H HE   A ARG   A 1 151 ? 9.30297   -18.41956 41.87776  0.563 20.66171 ? 629 ARG   B HE   1 
ATOM   2423 H HE   B ARG   A 1 151 ? 8.68255   -19.18905 37.30823  0.437 29.26426 ? 629 ARG   B HE   1 
ATOM   2424 H HH11 A ARG   A 1 151 ? 9.74831   -21.26682 40.21995  0.563 25.75619 ? 629 ARG   B HH11 1 
ATOM   2425 H HH11 B ARG   A 1 151 ? 11.47247  -18.79424 35.57908  0.437 27.95336 ? 629 ARG   B HH11 1 
ATOM   2426 H HH12 A ARG   A 1 151 ? 8.99506   -22.11729 41.18334  0.563 25.75619 ? 629 ARG   B HH12 1 
ATOM   2427 H HH12 B ARG   A 1 151 ? 10.85834  -19.03702 34.24390  0.437 27.95336 ? 629 ARG   B HH12 1 
ATOM   2428 H HH21 A ARG   A 1 151 ? 8.17873   -19.73594 43.30606  0.563 25.79309 ? 629 ARG   B HH21 1 
ATOM   2429 H HH21 B ARG   A 1 151 ? 7.78188   -19.56138 35.29189  0.437 25.00799 ? 629 ARG   B HH21 1 
ATOM   2430 H HH22 A ARG   A 1 151 ? 8.04934   -21.19625 43.04233  0.563 25.79309 ? 629 ARG   B HH22 1 
ATOM   2431 H HH22 B ARG   A 1 151 ? 8.62833   -19.50050 34.06771  0.437 25.00799 ? 629 ARG   B HH22 1 
ATOM   2432 N N    . ALA   A 1 152 ? 14.49408  -15.92772 37.85304  1.000 14.61869 ? 630 ALA   B N    1 
ATOM   2433 C CA   . ALA   A 1 152 ? 15.41222  -15.57067 36.77932  1.000 15.78433 ? 630 ALA   B CA   1 
ATOM   2434 C C    . ALA   A 1 152 ? 14.89496  -15.94933 35.40027  1.000 17.21116 ? 630 ALA   B C    1 
ATOM   2435 O O    . ALA   A 1 152 ? 15.26435  -15.31603 34.40308  1.000 18.20166 ? 630 ALA   B O    1 
ATOM   2436 C CB   . ALA   A 1 152 ? 16.78292  -16.23360 37.02281  1.000 16.56693 ? 630 ALA   B CB   1 
ATOM   2437 H H    . ALA   A 1 152 ? 14.82012  -16.46539 38.43973  1.000 17.49644 ? 630 ALA   B H    1 
ATOM   2438 H HA   . ALA   A 1 152 ? 15.51820  -14.60654 36.79065  1.000 18.89521 ? 630 ALA   B HA   1 
ATOM   2439 H HB1  . ALA   A 1 152 ? 17.38397  -15.99038 36.30137  1.000 19.83433 ? 630 ALA   B HB1  1 
ATOM   2440 H HB2  . ALA   A 1 152 ? 17.13885  -15.92128 37.86938  1.000 19.83433 ? 630 ALA   B HB2  1 
ATOM   2441 H HB3  . ALA   A 1 152 ? 16.66813  -17.19648 37.04730  1.000 19.83433 ? 630 ALA   B HB3  1 
ATOM   2442 N N    . GLY   A 1 153 ? 14.10438  -17.00466 35.29878  1.000 16.11673 ? 631 GLY   B N    1 
ATOM   2443 C CA   . GLY   A 1 153 ? 13.70138  -17.41851 33.95743  1.000 20.03602 ? 631 GLY   B CA   1 
ATOM   2444 C C    . GLY   A 1 153 ? 12.63474  -16.53751 33.28791  1.000 22.82979 ? 631 GLY   B C    1 
ATOM   2445 O O    . GLY   A 1 153 ? 12.35980  -16.73395 32.09614  1.000 20.99363 ? 631 GLY   B O    1 
ATOM   2446 H H    . GLY   A 1 153 ? 13.80194  -17.47501 35.95216  1.000 19.29409 ? 631 GLY   B H    1 
ATOM   2447 H HA2  . GLY   A 1 153 ? 14.48480  -17.41629 33.38545  1.000 23.99724 ? 631 GLY   B HA2  1 
ATOM   2448 H HA3  . GLY   A 1 153 ? 13.34834  -18.32068 34.00593  1.000 23.99724 ? 631 GLY   B HA3  1 
ATOM   2449 N N    . LEU   A 1 154 ? 12.06036  -15.58120 34.00063  1.000 16.68539 ? 632 LEU   B N    1 
ATOM   2450 C CA   . LEU   A 1 154 ? 10.89369  -14.87946 33.45624  1.000 17.71191 ? 632 LEU   B CA   1 
ATOM   2451 C C    . LEU   A 1 154 ? 11.25283  -13.93633 32.31118  1.000 17.20541 ? 632 LEU   B C    1 
ATOM   2452 O O    . LEU   A 1 154 ? 12.24740  -13.19560 32.38552  1.000 16.42967 ? 632 LEU   B O    1 
ATOM   2453 C CB   . LEU   A 1 154 ? 10.18966  -14.07722 34.54752  1.000 16.33180 ? 632 LEU   B CB   1 
ATOM   2454 C CG   . LEU   A 1 154 ? 9.63944   -14.78520 35.75453  1.000 17.46072 ? 632 LEU   B CG   1 
ATOM   2455 C CD1  . LEU   A 1 154 ? 9.17385   -13.77769 36.80732  1.000 15.45095 ? 632 LEU   B CD1  1 
ATOM   2456 C CD2  . LEU   A 1 154 ? 8.45829   -15.69543 35.31338  1.000 18.56078 ? 632 LEU   B CD2  1 
ATOM   2457 H H    . LEU   A 1 154 ? 12.31428  -15.32210 34.78036  1.000 19.97648 ? 632 LEU   B H    1 
ATOM   2458 H HA   . LEU   A 1 154 ? 10.29613  -15.55875 33.10641  1.000 21.20830 ? 632 LEU   B HA   1 
ATOM   2459 H HB2  . LEU   A 1 154 ? 10.82601  -13.42593 34.88186  1.000 19.55217 ? 632 LEU   B HB2  1 
ATOM   2460 H HB3  . LEU   A 1 154 ? 9.43859   -13.62462 34.13285  1.000 19.55217 ? 632 LEU   B HB3  1 
ATOM   2461 H HG   . LEU   A 1 154 ? 10.33091  -15.33194 36.15931  1.000 20.90688 ? 632 LEU   B HG   1 
ATOM   2462 H HD11 . LEU   A 1 154 ? 8.83456   -14.25985 37.57757  1.000 18.49515 ? 632 LEU   B HD11 1 
ATOM   2463 H HD12 . LEU   A 1 154 ? 9.92603   -13.22383 37.06880  1.000 18.49515 ? 632 LEU   B HD12 1 
ATOM   2464 H HD13 . LEU   A 1 154 ? 8.47263   -13.22543 36.42758  1.000 18.49515 ? 632 LEU   B HD13 1 
ATOM   2465 H HD21 . LEU   A 1 154 ? 8.07370   -16.11626 36.09817  1.000 22.22695 ? 632 LEU   B HD21 1 
ATOM   2466 H HD22 . LEU   A 1 154 ? 7.78958   -15.15158 34.86846  1.000 22.22695 ? 632 LEU   B HD22 1 
ATOM   2467 H HD23 . LEU   A 1 154 ? 8.79199   -16.37300 34.70474  1.000 22.22695 ? 632 LEU   B HD23 1 
ATOM   2468 N N    . VAL   A 1 155 ? 10.44738  -13.98360 31.23120  1.000 16.20907 ? 633 VAL   B N    1 
ATOM   2469 C CA   . VAL   A 1 155 ? 10.51664  -12.99102 30.16443  1.000 18.42559 ? 633 VAL   B CA   1 
ATOM   2470 C C    . VAL   A 1 155 ? 9.27531   -12.10028 30.14949  1.000 18.56651 ? 633 VAL   B C    1 
ATOM   2471 O O    . VAL   A 1 155 ? 9.24144   -11.10881 29.39319  1.000 18.25479 ? 633 VAL   B O    1 
ATOM   2472 C CB   . VAL   A 1 155 ? 10.71960  -13.63639 28.77564  1.000 24.87821 ? 633 VAL   B CB   1 
ATOM   2473 C CG1  . VAL   A 1 155 ? 12.06697  -14.31255 28.68841  1.000 27.37087 ? 633 VAL   B CG1  1 
ATOM   2474 C CG2  . VAL   A 1 155 ? 9.62805   -14.62429 28.50629  1.000 23.54776 ? 633 VAL   B CG2  1 
ATOM   2475 H H    . VAL   A 1 155 ? 9.85112   -14.58963 31.10159  1.000 19.40490 ? 633 VAL   B H    1 
ATOM   2476 H HA   . VAL   A 1 155 ? 11.29423  -12.43238 30.31992  1.000 22.06472 ? 633 VAL   B HA   1 
ATOM   2477 H HB   . VAL   A 1 155 ? 10.68855  -12.94089 28.10020  1.000 29.80787 ? 633 VAL   B HB   1 
ATOM   2478 H HG11 . VAL   A 1 155 ? 12.16968  -14.69914 27.80472  1.000 32.79906 ? 633 VAL   B HG11 1 
ATOM   2479 H HG12 . VAL   A 1 155 ? 12.76163  -13.65365 28.84398  1.000 32.79906 ? 633 VAL   B HG12 1 
ATOM   2480 H HG13 . VAL   A 1 155 ? 12.11495  -15.00908 29.36179  1.000 32.79906 ? 633 VAL   B HG13 1 
ATOM   2481 H HG21 . VAL   A 1 155 ? 9.75427   -15.00091 27.62135  1.000 28.21133 ? 633 VAL   B HG21 1 
ATOM   2482 H HG22 . VAL   A 1 155 ? 9.66662   -15.32727 29.17355  1.000 28.21133 ? 633 VAL   B HG22 1 
ATOM   2483 H HG23 . VAL   A 1 155 ? 8.77228   -14.17004 28.55348  1.000 28.21133 ? 633 VAL   B HG23 1 
ATOM   2484 N N    . THR   A 1 156 ? 8.24421   -12.45845 30.90416  1.000 17.86753 ? 634 THR   B N    1 
ATOM   2485 C CA   . THR   A 1 156 ? 7.06786   -11.65997 31.20151  1.000 19.76841 ? 634 THR   B CA   1 
ATOM   2486 C C    . THR   A 1 156 ? 6.72815   -11.94266 32.65520  1.000 20.08750 ? 634 THR   B C    1 
ATOM   2487 O O    . THR   A 1 156 ? 7.21272   -12.92337 33.22899  1.000 19.71723 ? 634 THR   B O    1 
ATOM   2488 C CB   . THR   A 1 156 ? 5.88105   -12.02949 30.28973  1.000 22.39670 ? 634 THR   B CB   1 
ATOM   2489 O OG1  . THR   A 1 156 ? 5.52223   -13.39339 30.53732  1.000 28.04307 ? 634 THR   B OG1  1 
ATOM   2490 C CG2  . THR   A 1 156 ? 6.23943   -11.88492 28.85070  1.000 27.44047 ? 634 THR   B CG2  1 
ATOM   2491 H H    . THR   A 1 156 ? 8.20166   -13.22719 31.28735  1.000 21.39505 ? 634 THR   B H    1 
ATOM   2492 H HA   . THR   A 1 156 ? 7.23760   -10.71325 31.07583  1.000 23.67610 ? 634 THR   B HA   1 
ATOM   2493 H HB   . THR   A 1 156 ? 5.13552   -11.43719 30.47485  1.000 26.83006 ? 634 THR   B HB   1 
ATOM   2494 H HG1  . THR   A 1 156 ? 4.86789   -13.61002 30.05721  1.000 33.60570 ? 634 THR   B HG1  1 
ATOM   2495 H HG21 . THR   A 1 156 ? 5.48651   -12.13854 28.29420  1.000 32.88258 ? 634 THR   B HG21 1 
ATOM   2496 H HG22 . THR   A 1 156 ? 6.47668   -10.96417 28.65877  1.000 32.88258 ? 634 THR   B HG22 1 
ATOM   2497 H HG23 . THR   A 1 156 ? 6.99447   -12.45547 28.63790  1.000 32.88258 ? 634 THR   B HG23 1 
ATOM   2498 N N    . PRO   A 1 157 ? 5.87987   -11.11566 33.26709  1.000 20.00933 ? 635 PRO   B N    1 
ATOM   2499 C CA   . PRO   A 1 157 ? 5.45705   -11.42492 34.62995  1.000 20.23207 ? 635 PRO   B CA   1 
ATOM   2500 C C    . PRO   A 1 157 ? 4.71527   -12.73180 34.65272  1.000 19.92440 ? 635 PRO   B C    1 
ATOM   2501 O O    . PRO   A 1 157 ? 4.07960   -13.13264 33.65321  1.000 19.19218 ? 635 PRO   B O    1 
ATOM   2502 C CB   . PRO   A 1 157 ? 4.53057   -10.24640 34.99044  1.000 21.74397 ? 635 PRO   B CB   1 
ATOM   2503 C CG   . PRO   A 1 157 ? 4.80417   -9.17624  33.97820  1.000 24.80219 ? 635 PRO   B CG   1 
ATOM   2504 C CD   . PRO   A 1 157 ? 5.20801   -9.90760  32.72810  1.000 24.66034 ? 635 PRO   B CD   1 
ATOM   2505 H HA   . PRO   A 1 157 ? 6.21142   -11.45111 35.23916  1.000 24.23250 ? 635 PRO   B HA   1 
ATOM   2506 H HB2  . PRO   A 1 157 ? 3.60530   -10.53384 34.94399  1.000 26.04677 ? 635 PRO   B HB2  1 
ATOM   2507 H HB3  . PRO   A 1 157 ? 4.73603   -9.93280  35.88506  1.000 26.04677 ? 635 PRO   B HB3  1 
ATOM   2508 H HG2  . PRO   A 1 157 ? 4.00208   -8.65184  33.82806  1.000 29.71664 ? 635 PRO   B HG2  1 
ATOM   2509 H HG3  . PRO   A 1 157 ? 5.52170   -8.60303  34.29041  1.000 29.71664 ? 635 PRO   B HG3  1 
ATOM   2510 H HD2  . PRO   A 1 157 ? 4.43151   -10.14774 32.19868  1.000 29.54642 ? 635 PRO   B HD2  1 
ATOM   2511 H HD3  . PRO   A 1 157 ? 5.82082   -9.37622  32.19612  1.000 29.54642 ? 635 PRO   B HD3  1 
ATOM   2512 N N    . PRO   A 1 158 ? 4.76547   -13.46164 35.76523  1.000 19.55336 ? 636 PRO   B N    1 
ATOM   2513 C CA   . PRO   A 1 158 ? 4.08205   -14.76154 35.82953  1.000 17.79127 ? 636 PRO   B CA   1 
ATOM   2514 C C    . PRO   A 1 158 ? 2.58802   -14.55954 35.93180  1.000 16.50509 ? 636 PRO   B C    1 
ATOM   2515 O O    . PRO   A 1 158 ? 2.11898   -13.48565 36.34602  1.000 14.22797 ? 636 PRO   B O    1 
ATOM   2516 C CB   . PRO   A 1 158 ? 4.64039   -15.40488 37.09842  1.000 16.93743 ? 636 PRO   B CB   1 
ATOM   2517 C CG   . PRO   A 1 158 ? 5.22379   -14.27570 37.91499  1.000 18.53727 ? 636 PRO   B CG   1 
ATOM   2518 C CD   . PRO   A 1 158 ? 5.21306   -13.00126 37.09772  1.000 18.10731 ? 636 PRO   B CD   1 
ATOM   2519 H HA   . PRO   A 1 158 ? 4.30161   -15.31445 35.06338  1.000 21.30354 ? 636 PRO   B HA   1 
ATOM   2520 H HB2  . PRO   A 1 158 ? 3.92466   -15.84516 37.58297  1.000 20.27892 ? 636 PRO   B HB2  1 
ATOM   2521 H HB3  . PRO   A 1 158 ? 5.32660   -16.04873 36.86287  1.000 20.27892 ? 636 PRO   B HB3  1 
ATOM   2522 H HG2  . PRO   A 1 158 ? 4.68702   -14.15931 38.71451  1.000 22.19874 ? 636 PRO   B HG2  1 
ATOM   2523 H HG3  . PRO   A 1 158 ? 6.13475   -14.50440 38.15738  1.000 22.19874 ? 636 PRO   B HG3  1 
ATOM   2524 H HD2  . PRO   A 1 158 ? 4.58958   -12.35748 37.46881  1.000 21.68279 ? 636 PRO   B HD2  1 
ATOM   2525 H HD3  . PRO   A 1 158 ? 6.10091   -12.61356 37.04963  1.000 21.68279 ? 636 PRO   B HD3  1 
ATOM   2526 N N    . PRO   A 1 159 ? 1.81516   -15.58757 35.63022  1.000 15.49525 ? 637 PRO   B N    1 
ATOM   2527 C CA   . PRO   A 1 159 ? 0.36255   -15.49147 35.84866  1.000 16.52780 ? 637 PRO   B CA   1 
ATOM   2528 C C    . PRO   A 1 159 ? 0.03532   -15.53932 37.32927  1.000 15.43587 ? 637 PRO   B C    1 
ATOM   2529 O O    . PRO   A 1 159 ? 0.75541   -16.14986 38.12639  1.000 14.60054 ? 637 PRO   B O    1 
ATOM   2530 C CB   . PRO   A 1 159 ? -0.19845  -16.73127 35.12561  1.000 16.45774 ? 637 PRO   B CB   1 
ATOM   2531 C CG   . PRO   A 1 159 ? 0.93553   -17.68325 35.06294  1.000 19.44273 ? 637 PRO   B CG   1 
ATOM   2532 C CD   . PRO   A 1 159 ? 2.23006   -16.88333 35.07021  1.000 17.57271 ? 637 PRO   B CD   1 
ATOM   2533 H HA   . PRO   A 1 159 ? 0.00169   -14.68636 35.44559  1.000 19.78737 ? 637 PRO   B HA   1 
ATOM   2534 H HB2  . PRO   A 1 159 ? -0.93677  -17.10352 35.63277  1.000 19.70330 ? 637 PRO   B HB2  1 
ATOM   2535 H HB3  . PRO   A 1 159 ? -0.49693  -16.48760 34.23542  1.000 19.70330 ? 637 PRO   B HB3  1 
ATOM   2536 H HG2  . PRO   A 1 159 ? 0.90030   -18.26997 35.83457  1.000 23.28529 ? 637 PRO   B HG2  1 
ATOM   2537 H HG3  . PRO   A 1 159 ? 0.86825   -18.20365 34.24713  1.000 23.28529 ? 637 PRO   B HG3  1 
ATOM   2538 H HD2  . PRO   A 1 159 ? 2.89591   -17.30711 35.63408  1.000 21.04126 ? 637 PRO   B HD2  1 
ATOM   2539 H HD3  . PRO   A 1 159 ? 2.57648   -16.77685 34.17046  1.000 21.04126 ? 637 PRO   B HD3  1 
ATOM   2540 N N    . LYS   A 1 160 ? -1.06202  -14.88052 37.69589  1.000 13.76473 ? 638 LYS   B N    1 
ATOM   2541 C CA   A LYS   A 1 160 ? -1.54289  -14.96065 39.07008  0.410 15.76701 ? 638 LYS   B CA   1 
ATOM   2542 C CA   B LYS   A 1 160 ? -1.54045  -14.96411 39.07222  0.590 15.32310 ? 638 LYS   B CA   1 
ATOM   2543 C C    . LYS   A 1 160 ? -2.04951  -16.36137 39.38625  1.000 15.72433 ? 638 LYS   B C    1 
ATOM   2544 O O    . LYS   A 1 160 ? -2.00017  -16.79989 40.54012  1.000 13.67484 ? 638 LYS   B O    1 
ATOM   2545 C CB   A LYS   A 1 160 ? -2.68502  -13.97288 39.32335  0.410 17.68465 ? 638 LYS   B CB   1 
ATOM   2546 C CB   B LYS   A 1 160 ? -2.66083  -13.95149 39.31381  0.590 17.10910 ? 638 LYS   B CB   1 
ATOM   2547 C CG   A LYS   A 1 160 ? -2.52985  -12.60008 38.72356  0.410 17.03014 ? 638 LYS   B CG   1 
ATOM   2548 C CG   B LYS   A 1 160 ? -2.21686  -12.51771 39.21389  0.590 16.96176 ? 638 LYS   B CG   1 
ATOM   2549 C CD   A LYS   A 1 160 ? -3.93940  -12.06981 38.38415  0.410 18.81194 ? 638 LYS   B CD   1 
ATOM   2550 C CD   B LYS   A 1 160 ? -3.42021  -11.57303 39.30678  0.590 18.64356 ? 638 LYS   B CD   1 
ATOM   2551 C CE   A LYS   A 1 160 ? -4.01447  -10.57965 38.28452  0.410 19.72314 ? 638 LYS   B CE   1 
ATOM   2552 C CE   B LYS   A 1 160 ? -3.00743  -10.13558 39.23573  0.590 18.46634 ? 638 LYS   B CE   1 
ATOM   2553 N NZ   A LYS   A 1 160 ? -5.44545  -10.16855 38.13533  0.410 18.12711 ? 638 LYS   B NZ   1 
ATOM   2554 N NZ   B LYS   A 1 160 ? -4.19279  -9.15826  39.03511  0.590 20.65392 ? 638 LYS   B NZ   1 
ATOM   2555 H H    A LYS   A 1 160 ? -1.53859  -14.38808 37.17629  0.410 16.47169 ? 638 LYS   B H    1 
ATOM   2556 H H    B LYS   A 1 160 ? -1.53897  -14.38748 37.17720  0.590 16.47169 ? 638 LYS   B H    1 
ATOM   2557 H HA   A LYS   A 1 160 ? -0.80353  -14.72715 39.65293  0.410 18.87443 ? 638 LYS   B HA   1 
ATOM   2558 H HA   B LYS   A 1 160 ? -0.80558  -14.74904 39.66771  0.590 18.34173 ? 638 LYS   B HA   1 
ATOM   2559 H HB2  A LYS   A 1 160 ? -3.49891  -14.35303 38.95735  0.410 21.17559 ? 638 LYS   B HB2  1 
ATOM   2560 H HB2  B LYS   A 1 160 ? -3.35610  -14.09258 38.65229  0.590 20.48493 ? 638 LYS   B HB2  1 
ATOM   2561 H HB3  A LYS   A 1 160 ? -2.77532  -13.85604 40.28205  0.410 21.17559 ? 638 LYS   B HB3  1 
ATOM   2562 H HB3  B LYS   A 1 160 ? -3.01807  -14.08904 40.20508  0.590 20.48493 ? 638 LYS   B HB3  1 
ATOM   2563 H HG2  A LYS   A 1 160 ? -2.10764  -12.00211 39.36001  0.410 20.39018 ? 638 LYS   B HG2  1 
ATOM   2564 H HG2  B LYS   A 1 160 ? -1.60823  -12.31476 39.94141  0.590 20.30812 ? 638 LYS   B HG2  1 
ATOM   2565 H HG3  A LYS   A 1 160 ? -2.00144  -12.64701 37.91147  0.410 20.39018 ? 638 LYS   B HG3  1 
ATOM   2566 H HG3  B LYS   A 1 160 ? -1.77580  -12.37292 38.36218  0.590 20.30812 ? 638 LYS   B HG3  1 
ATOM   2567 H HD2  A LYS   A 1 160 ? -4.21422  -12.43711 37.52947  0.410 22.52834 ? 638 LYS   B HD2  1 
ATOM   2568 H HD2  B LYS   A 1 160 ? -4.02488  -11.75175 38.56967  0.590 22.32628 ? 638 LYS   B HD2  1 
ATOM   2569 H HD3  A LYS   A 1 160 ? -4.55488  -12.35066 39.07927  0.410 22.52834 ? 638 LYS   B HD3  1 
ATOM   2570 H HD3  B LYS   A 1 160 ? -3.87516  -11.71656 40.15136  0.590 22.32628 ? 638 LYS   B HD3  1 
ATOM   2571 H HE2  A LYS   A 1 160 ? -3.65347  -10.17655 39.08956  0.410 23.62179 ? 638 LYS   B HE2  1 
ATOM   2572 H HE2  B LYS   A 1 160 ? -2.56338  -9.89617  40.06423  0.590 22.11362 ? 638 LYS   B HE2  1 
ATOM   2573 H HE3  A LYS   A 1 160 ? -3.51710  -10.27532 37.50935  0.410 23.62179 ? 638 LYS   B HE3  1 
ATOM   2574 H HE3  B LYS   A 1 160 ? -2.39966  -10.02107 38.48847  0.590 22.11362 ? 638 LYS   B HE3  1 
ATOM   2575 H HZ1  A LYS   A 1 160 ? -5.91581  -10.44228 38.83955  0.410 21.70655 ? 638 LYS   B HZ1  1 
ATOM   2576 H HZ1  B LYS   A 1 160 ? -3.89440  -8.32038  39.00299  0.590 24.73871 ? 638 LYS   B HZ1  1 
ATOM   2577 H HZ2  A LYS   A 1 160 ? -5.50301  -9.28237  38.07631  0.410 21.70655 ? 638 LYS   B HZ2  1 
ATOM   2578 H HZ2  B LYS   A 1 160 ? -4.61490  -9.34392  38.27389  0.590 24.73871 ? 638 LYS   B HZ2  1 
ATOM   2579 H HZ3  A LYS   A 1 160 ? -5.79086  -10.53010 37.39907  0.410 21.70655 ? 638 LYS   B HZ3  1 
ATOM   2580 H HZ3  B LYS   A 1 160 ? -4.76772  -9.23444  39.71020  0.590 24.73871 ? 638 LYS   B HZ3  1 
ATOM   2581 N N    . ASN   A 1 161 ? -2.53157  -17.04563 38.39459  1.000 14.71730 ? 639 ASN   B N    1 
ATOM   2582 C CA   . ASN   A 1 161 ? -3.22910  -18.32005 38.52502  1.000 15.72878 ? 639 ASN   B CA   1 
ATOM   2583 C C    . ASN   A 1 161 ? -2.70896  -19.23292 37.42039  1.000 15.17192 ? 639 ASN   B C    1 
ATOM   2584 O O    . ASN   A 1 161 ? -2.83825  -18.89822 36.24516  1.000 16.55608 ? 639 ASN   B O    1 
ATOM   2585 C CB   . ASN   A 1 161 ? -4.72987  -18.11881 38.41026  1.000 15.17681 ? 639 ASN   B CB   1 
ATOM   2586 C CG   . ASN   A 1 161 ? -5.50735  -19.35910 38.78843  1.000 17.63441 ? 639 ASN   B CG   1 
ATOM   2587 O OD1  . ASN   A 1 161 ? -5.17472  -20.47083 38.34692  1.000 16.58174 ? 639 ASN   B OD1  1 
ATOM   2588 N ND2  . ASN   A 1 161 ? -6.54168  -19.17891 39.60631  1.000 19.67113 ? 639 ASN   B ND2  1 
ATOM   2589 H H    . ASN   A 1 161 ? -2.47240  -16.79074 37.57536  1.000 17.61478 ? 639 ASN   B H    1 
ATOM   2590 H HA   . ASN   A 1 161 ? -3.06519  -18.72809 39.38962  1.000 18.82855 ? 639 ASN   B HA   1 
ATOM   2591 H HB2  . ASN   A 1 161 ? -5.00030  -17.40075 39.00369  1.000 18.16618 ? 639 ASN   B HB2  1 
ATOM   2592 H HB3  . ASN   A 1 161 ? -4.95073  -17.89234 37.49329  1.000 18.16618 ? 639 ASN   B HB3  1 
ATOM   2593 H HD21 . ASN   A 1 161 ? -7.01745  -19.85167 39.85256  1.000 23.55938 ? 639 ASN   B HD21 1 
ATOM   2594 H HD22 . ASN   A 1 161 ? -6.73428  -18.38971 39.88857  1.000 23.55938 ? 639 ASN   B HD22 1 
ATOM   2595 N N    . PRO   A 1 162 ? -2.11524  -20.37615 37.76322  1.000 15.83419 ? 640 PRO   B N    1 
ATOM   2596 C CA   . PRO   A 1 162 ? -1.51061  -21.22152 36.72251  1.000 17.38381 ? 640 PRO   B CA   1 
ATOM   2597 C C    . PRO   A 1 162 ? -2.51040  -21.74546 35.71549  1.000 17.65527 ? 640 PRO   B C    1 
ATOM   2598 O O    . PRO   A 1 162 ? -2.12019  -22.12365 34.60707  1.000 16.66229 ? 640 PRO   B O    1 
ATOM   2599 C CB   . PRO   A 1 162 ? -0.85588  -22.37109 37.52283  1.000 18.50862 ? 640 PRO   B CB   1 
ATOM   2600 C CG   . PRO   A 1 162 ? -1.54351  -22.40446 38.81311  1.000 19.26527 ? 640 PRO   B CG   1 
ATOM   2601 C CD   . PRO   A 1 162 ? -1.97906  -20.98073 39.11636  1.000 17.43945 ? 640 PRO   B CD   1 
ATOM   2602 H HA   . PRO   A 1 162 ? -0.81673  -20.72771 36.25820  1.000 20.81458 ? 640 PRO   B HA   1 
ATOM   2603 H HB2  . PRO   A 1 162 ? -0.97515  -23.20848 37.04803  1.000 22.16436 ? 640 PRO   B HB2  1 
ATOM   2604 H HB3  . PRO   A 1 162 ? 0.08940   -22.18885 37.64173  1.000 22.16436 ? 640 PRO   B HB3  1 
ATOM   2605 H HG2  . PRO   A 1 162 ? -2.31428  -22.99035 38.75348  1.000 23.07234 ? 640 PRO   B HG2  1 
ATOM   2606 H HG3  . PRO   A 1 162 ? -0.93420  -22.72627 39.49580  1.000 23.07234 ? 640 PRO   B HG3  1 
ATOM   2607 H HD2  . PRO   A 1 162 ? -2.82721  -20.97091 39.58694  1.000 20.88136 ? 640 PRO   B HD2  1 
ATOM   2608 H HD3  . PRO   A 1 162 ? -1.30538  -20.51602 39.63703  1.000 20.88136 ? 640 PRO   B HD3  1 
ATOM   2609 N N    . HIS   A 1 163 ? -3.79229  -21.77340 36.05306  1.000 16.33967 ? 641 HIS   B N    1 
ATOM   2610 C CA   . HIS   A 1 163 ? -4.79973  -22.26696 35.12466  1.000 16.13140 ? 641 HIS   B CA   1 
ATOM   2611 C C    . HIS   A 1 163 ? -5.41256  -21.17121 34.28871  1.000 19.56501 ? 641 HIS   B C    1 
ATOM   2612 O O    . HIS   A 1 163 ? -6.30901  -21.45418 33.50012  1.000 16.51105 ? 641 HIS   B O    1 
ATOM   2613 C CB   . HIS   A 1 163 ? -5.87744  -23.06258 35.88387  1.000 17.94576 ? 641 HIS   B CB   1 
ATOM   2614 C CG   . HIS   A 1 163 ? -5.30874  -24.22817 36.62436  1.000 16.06129 ? 641 HIS   B CG   1 
ATOM   2615 N ND1  . HIS   A 1 163 ? -4.89471  -25.38459 35.99313  1.000 17.85521 ? 641 HIS   B ND1  1 
ATOM   2616 C CD2  . HIS   A 1 163 ? -4.98311  -24.37399 37.93327  1.000 16.93921 ? 641 HIS   B CD2  1 
ATOM   2617 C CE1  . HIS   A 1 163 ? -4.37247  -26.20373 36.88501  1.000 17.49200 ? 641 HIS   B CE1  1 
ATOM   2618 N NE2  . HIS   A 1 163 ? -4.37201  -25.59786 38.05819  1.000 15.62102 ? 641 HIS   B NE2  1 
ATOM   2619 H H    . HIS   A 1 163 ? -4.10233  -21.51269 36.81168  1.000 19.56162 ? 641 HIS   B H    1 
ATOM   2620 H HA   . HIS   A 1 163 ? -4.38045  -22.88566 34.50634  1.000 19.31169 ? 641 HIS   B HA   1 
ATOM   2621 H HB2  . HIS   A 1 163 ? -6.30909  -22.47821 36.52660  1.000 21.48893 ? 641 HIS   B HB2  1 
ATOM   2622 H HB3  . HIS   A 1 163 ? -6.53019  -23.39752 35.24934  1.000 21.48893 ? 641 HIS   B HB3  1 
ATOM   2623 H HD2  . HIS   A 1 163 ? -5.14302  -23.76241 38.61540  1.000 20.28106 ? 641 HIS   B HD2  1 
ATOM   2624 H HE1  . HIS   A 1 163 ? -4.05786  -27.06248 36.71626  1.000 20.94442 ? 641 HIS   B HE1  1 
ATOM   2625 H HE2  . HIS   A 1 163 ? -4.04176  -25.91838 38.78469  1.000 18.69924 ? 641 HIS   B HE2  1 
ATOM   2626 N N    . ASN   A 1 164 ? -4.90729  -19.93623 34.40783  1.000 17.16833 ? 642 ASN   B N    1 
ATOM   2627 C CA   . ASN   A 1 164 ? -5.31687  -18.81885 33.54564  1.000 18.16845 ? 642 ASN   B CA   1 
ATOM   2628 C C    . ASN   A 1 164 ? -4.02369  -18.09717 33.17345  1.000 18.46000 ? 642 ASN   B C    1 
ATOM   2629 O O    . ASN   A 1 164 ? -3.68747  -17.04807 33.73887  1.000 16.21511 ? 642 ASN   B O    1 
ATOM   2630 C CB   . ASN   A 1 164 ? -6.27240  -17.88356 34.25467  1.000 18.66731 ? 642 ASN   B CB   1 
ATOM   2631 C CG   . ASN   A 1 164 ? -6.79505  -16.80299 33.35091  1.000 21.25144 ? 642 ASN   B CG   1 
ATOM   2632 O OD1  . ASN   A 1 164 ? -6.47928  -16.76734 32.15700  1.000 24.28428 ? 642 ASN   B OD1  1 
ATOM   2633 N ND2  . ASN   A 1 164 ? -7.58732  -15.92914 33.90614  1.000 19.16617 ? 642 ASN   B ND2  1 
ATOM   2634 H H    . ASN   A 1 164 ? -4.31494  -19.71721 34.99157  1.000 20.55601 ? 642 ASN   B H    1 
ATOM   2635 H HA   . ASN   A 1 164 ? -5.77327  -19.14275 32.75337  1.000 21.75615 ? 642 ASN   B HA   1 
ATOM   2636 H HB2  . ASN   A 1 164 ? -7.02931  -18.39311 34.58382  1.000 22.35478 ? 642 ASN   B HB2  1 
ATOM   2637 H HB3  . ASN   A 1 164 ? -5.81062  -17.45976 34.99498  1.000 22.35478 ? 642 ASN   B HB3  1 
ATOM   2638 H HD21 . ASN   A 1 164 ? -7.91664  -15.28806 33.43690  1.000 22.95342 ? 642 ASN   B HD21 1 
ATOM   2639 H HD22 . ASN   A 1 164 ? -7.78064  -15.99375 34.74163  1.000 22.95342 ? 642 ASN   B HD22 1 
ATOM   2640 N N    . PRO   A 1 165 ? -3.25549  -18.65844 32.23604  1.000 16.81470 ? 643 PRO   B N    1 
ATOM   2641 C CA   . PRO   A 1 165 ? -1.87758  -18.19516 32.04157  1.000 18.66149 ? 643 PRO   B CA   1 
ATOM   2642 C C    . PRO   A 1 165 ? -1.76455  -16.78219 31.49194  1.000 18.47642 ? 643 PRO   B C    1 
ATOM   2643 O O    . PRO   A 1 165 ? -0.65418  -16.22779 31.54258  1.000 20.35693 ? 643 PRO   B O    1 
ATOM   2644 C CB   . PRO   A 1 165 ? -1.29192  -19.21799 31.04151  1.000 21.54864 ? 643 PRO   B CB   1 
ATOM   2645 C CG   . PRO   A 1 165 ? -2.21179  -20.41550 31.10492  1.000 22.73288 ? 643 PRO   B CG   1 
ATOM   2646 C CD   . PRO   A 1 165 ? -3.55788  -19.86803 31.43442  1.000 21.06044 ? 643 PRO   B CD   1 
ATOM   2647 H HA   . PRO   A 1 165 ? -1.39645  -18.25086 32.88199  1.000 22.34781 ? 643 PRO   B HA   1 
ATOM   2648 H HB2  . PRO   A 1 165 ? -1.28230  -18.83661 30.14969  1.000 25.81238 ? 643 PRO   B HB2  1 
ATOM   2649 H HB3  . PRO   A 1 165 ? -0.39130  -19.45966 31.30871  1.000 25.81238 ? 643 PRO   B HB3  1 
ATOM   2650 H HG2  . PRO   A 1 165 ? -2.22381  -20.86623 30.24608  1.000 27.23347 ? 643 PRO   B HG2  1 
ATOM   2651 H HG3  . PRO   A 1 165 ? -1.90937  -21.02572 31.79563  1.000 27.23347 ? 643 PRO   B HG3  1 
ATOM   2652 H HD2  . PRO   A 1 165 ? -4.04110  -19.63356 30.62669  1.000 25.22654 ? 643 PRO   B HD2  1 
ATOM   2653 H HD3  . PRO   A 1 165 ? -4.07094  -20.50610 31.95455  1.000 25.22654 ? 643 PRO   B HD3  1 
ATOM   2654 N N    . THR   A 1 166 ? -2.84540  -16.18726 30.98211  1.000 18.69946 ? 644 THR   B N    1 
ATOM   2655 C CA   . THR   A 1 166 ? -2.73406  -14.85363 30.39360  1.000 17.86065 ? 644 THR   B CA   1 
ATOM   2656 C C    . THR   A 1 166 ? -3.08417  -13.72647 31.36258  1.000 19.22091 ? 644 THR   B C    1 
ATOM   2657 O O    . THR   A 1 166 ? -2.87423  -12.56003 31.02639  1.000 21.08093 ? 644 THR   B O    1 
ATOM   2658 C CB   . THR   A 1 166 ? -3.62744  -14.74969 29.14180  1.000 19.81535 ? 644 THR   B CB   1 
ATOM   2659 O OG1  . THR   A 1 166 ? -4.98199  -14.94778 29.49954  1.000 22.78450 ? 644 THR   B OG1  1 
ATOM   2660 C CG2  . THR   A 1 166 ? -3.21483  -15.76124 28.12085  1.000 23.15828 ? 644 THR   B CG2  1 
ATOM   2661 H H    . THR   A 1 166 ? -3.63454  -16.52874 30.96643  1.000 22.39337 ? 644 THR   B H    1 
ATOM   2662 H HA   . THR   A 1 166 ? -1.81449  -14.71870 30.11594  1.000 21.38679 ? 644 THR   B HA   1 
ATOM   2663 H HB   . THR   A 1 166 ? -3.53408  -13.86820 28.74790  1.000 23.73244 ? 644 THR   B HB   1 
ATOM   2664 H HG1  . THR   A 1 166 ? -5.08364  -15.71498 29.82615  1.000 27.29541 ? 644 THR   B HG1  1 
ATOM   2665 H HG21 . THR   A 1 166 ? -3.74851  -15.65843 27.31741  1.000 27.74395 ? 644 THR   B HG21 1 
ATOM   2666 H HG22 . THR   A 1 166 ? -2.27917  -15.64173 27.89469  1.000 27.74395 ? 644 THR   B HG22 1 
ATOM   2667 H HG23 . THR   A 1 166 ? -3.34217  -16.65687 28.47088  1.000 27.74395 ? 644 THR   B HG23 1 
ATOM   2668 N N    . ASP   A 1 167 ? -3.57930  -14.03135 32.56857  1.000 17.88645 ? 645 ASP   B N    1 
ATOM   2669 C CA   . ASP   A 1 167 ? -3.93149  -12.99869 33.54575  1.000 18.65815 ? 645 ASP   B CA   1 
ATOM   2670 C C    . ASP   A 1 167 ? -2.71330  -12.80609 34.45156  1.000 18.55903 ? 645 ASP   B C    1 
ATOM   2671 O O    . ASP   A 1 167 ? -2.47234  -13.60843 35.36444  1.000 17.40918 ? 645 ASP   B O    1 
ATOM   2672 C CB   . ASP   A 1 167 ? -5.16680  -13.41324 34.33828  1.000 20.37925 ? 645 ASP   B CB   1 
ATOM   2673 C CG   . ASP   A 1 167 ? -5.69958  -12.28740 35.20290  1.000 21.23699 ? 645 ASP   B CG   1 
ATOM   2674 O OD1  . ASP   A 1 167 ? -5.39251  -11.11124 34.93190  1.000 24.63579 ? 645 ASP   B OD1  1 
ATOM   2675 O OD2  . ASP   A 1 167 ? -6.45408  -12.57096 36.16212  1.000 23.78597 ? 645 ASP   B OD2  1 
ATOM   2676 H H    . ASP   A 1 167 ? -3.72021  -14.83398 32.84339  1.000 21.41775 ? 645 ASP   B H    1 
ATOM   2677 H HA   . ASP   A 1 167 ? -4.12985  -12.16138 33.09802  1.000 22.34379 ? 645 ASP   B HA   1 
ATOM   2678 H HB2  . ASP   A 1 167 ? -5.86689  -13.67706 33.72089  1.000 24.40912 ? 645 ASP   B HB2  1 
ATOM   2679 H HB3  . ASP   A 1 167 ? -4.93804  -14.15670 34.91780  1.000 24.40912 ? 645 ASP   B HB3  1 
ATOM   2680 N N    . LEU   A 1 168 ? -1.92468  -11.75721 34.17275  1.000 17.85318 ? 646 LEU   B N    1 
ATOM   2681 C CA   . LEU   A 1 168 ? -0.57099  -11.63738 34.68782  1.000 16.63439 ? 646 LEU   B CA   1 
ATOM   2682 C C    . LEU   A 1 168 ? -0.46129  -10.67814 35.85939  1.000 15.73034 ? 646 LEU   B C    1 
ATOM   2683 O O    . LEU   A 1 168 ? -1.22845  -9.73122  35.99451  1.000 15.02996 ? 646 LEU   B O    1 
ATOM   2684 C CB   . LEU   A 1 168 ? 0.38411   -11.13148 33.60555  1.000 17.03932 ? 646 LEU   B CB   1 
ATOM   2685 C CG   . LEU   A 1 168 ? 0.46475   -11.93934 32.29060  1.000 19.96991 ? 646 LEU   B CG   1 
ATOM   2686 C CD1  . LEU   A 1 168 ? 1.55818   -11.34736 31.41069  1.000 21.56250 ? 646 LEU   B CD1  1 
ATOM   2687 C CD2  . LEU   A 1 168 ? 0.71283   -13.41234 32.58576  1.000 17.90321 ? 646 LEU   B CD2  1 
ATOM   2688 H H    . LEU   A 1 168 ? -2.16421  -11.09580 33.67801  1.000 21.37783 ? 646 LEU   B H    1 
ATOM   2689 H HA   . LEU   A 1 168 ? -0.31478  -12.52183 34.99280  1.000 19.91529 ? 646 LEU   B HA   1 
ATOM   2690 H HB2  . LEU   A 1 168 ? 0.11112   -10.23201 33.36609  1.000 20.40120 ? 646 LEU   B HB2  1 
ATOM   2691 H HB3  . LEU   A 1 168 ? 1.27804   -11.11777 33.98184  1.000 20.40120 ? 646 LEU   B HB3  1 
ATOM   2692 H HG   . LEU   A 1 168 ? -0.37513  -11.88792 31.80806  1.000 23.91791 ? 646 LEU   B HG   1 
ATOM   2693 H HD11 . LEU   A 1 168 ? 1.60945   -11.85536 30.58594  1.000 25.82901 ? 646 LEU   B HD11 1 
ATOM   2694 H HD12 . LEU   A 1 168 ? 1.34087   -10.42220 31.21637  1.000 25.82901 ? 646 LEU   B HD12 1 
ATOM   2695 H HD13 . LEU   A 1 168 ? 2.40430   -11.39633 31.88248  1.000 25.82901 ? 646 LEU   B HD13 1 
ATOM   2696 H HD21 . LEU   A 1 168 ? 0.86636   -13.88036 31.75013  1.000 21.43786 ? 646 LEU   B HD21 1 
ATOM   2697 H HD22 . LEU   A 1 168 ? 1.49190   -13.49291 33.15800  1.000 21.43786 ? 646 LEU   B HD22 1 
ATOM   2698 H HD23 . LEU   A 1 168 ? -0.06542  -13.78027 33.03281  1.000 21.43786 ? 646 LEU   B HD23 1 
ATOM   2699 N N    . PHE   A 1 169 ? 0.49924   -10.95284 36.73503  1.000 15.11473 ? 647 PHE   B N    1 
ATOM   2700 C CA   . PHE   A 1 169 ? 0.97584   -9.91302  37.61414  1.000 14.99602 ? 647 PHE   B CA   1 
ATOM   2701 C C    . PHE   A 1 169 ? 1.49920   -8.75723  36.77876  1.000 14.19362 ? 647 PHE   B C    1 
ATOM   2702 O O    . PHE   A 1 169 ? 1.90347   -8.93099  35.61770  1.000 13.43427 ? 647 PHE   B O    1 
ATOM   2703 C CB   . PHE   A 1 169 ? 2.07551   -10.44401 38.52310  1.000 14.34577 ? 647 PHE   B CB   1 
ATOM   2704 C CG   . PHE   A 1 169 ? 1.56266   -11.27308 39.66873  1.000 13.56178 ? 647 PHE   B CG   1 
ATOM   2705 C CD1  . PHE   A 1 169 ? 1.02200   -10.67076 40.78829  1.000 15.49340 ? 647 PHE   B CD1  1 
ATOM   2706 C CD2  . PHE   A 1 169 ? 1.67221   -12.66569 39.63424  1.000 14.32941 ? 647 PHE   B CD2  1 
ATOM   2707 C CE1  . PHE   A 1 169 ? 0.57367   -11.40452 41.85036  1.000 16.55160 ? 647 PHE   B CE1  1 
ATOM   2708 C CE2  . PHE   A 1 169 ? 1.24353   -13.41802 40.71222  1.000 14.25480 ? 647 PHE   B CE2  1 
ATOM   2709 C CZ   . PHE   A 1 169 ? 0.69183   -12.82473 41.81344  1.000 16.14342 ? 647 PHE   B CZ   1 
ATOM   2710 H H    . PHE   A 1 169 ? 0.87858   -11.71850 36.83239  1.000 18.09169 ? 647 PHE   B H    1 
ATOM   2711 H HA   . PHE   A 1 169 ? 0.25634   -9.59542  38.18190  1.000 17.94924 ? 647 PHE   B HA   1 
ATOM   2712 H HB2  . PHE   A 1 169 ? 2.67296   -10.99992 37.99876  1.000 17.16893 ? 647 PHE   B HB2  1 
ATOM   2713 H HB3  . PHE   A 1 169 ? 2.56293   -9.69262  38.89557  1.000 17.16893 ? 647 PHE   B HB3  1 
ATOM   2714 H HD1  . PHE   A 1 169 ? 0.96168   -9.74325  40.81994  1.000 18.54610 ? 647 PHE   B HD1  1 
ATOM   2715 H HD2  . PHE   A 1 169 ? 2.03299   -13.08598 38.88719  1.000 17.14931 ? 647 PHE   B HD2  1 
ATOM   2716 H HE1  . PHE   A 1 169 ? 0.19611   -10.98260 42.58815  1.000 19.81593 ? 647 PHE   B HE1  1 
ATOM   2717 H HE2  . PHE   A 1 169 ? 1.33200   -14.34348 40.68774  1.000 17.05977 ? 647 PHE   B HE2  1 
ATOM   2718 H HZ   . PHE   A 1 169 ? 0.39753   -13.34077 42.52897  1.000 19.32612 ? 647 PHE   B HZ   1 
ATOM   2719 N N    . ASP   A 1 170 ? 1.50401   -7.55775  37.39001  1.000 12.76107 ? 648 ASP   B N    1 
ATOM   2720 C CA   . ASP   A 1 170 ? 1.98007   -6.39146  36.65210  1.000 13.56191 ? 648 ASP   B CA   1 
ATOM   2721 C C    . ASP   A 1 170 ? 3.50102   -6.26231  36.66098  1.000 13.39067 ? 648 ASP   B C    1 
ATOM   2722 O O    . ASP   A 1 170 ? 4.08670   -5.74660  35.69296  1.000 12.66863 ? 648 ASP   B O    1 
ATOM   2723 C CB   . ASP   A 1 170 ? 1.34630   -5.14565  37.19634  1.000 13.92369 ? 648 ASP   B CB   1 
ATOM   2724 C CG   . ASP   A 1 170 ? -0.17038  -5.20163  37.10784  1.000 14.94236 ? 648 ASP   B CG   1 
ATOM   2725 O OD1  . ASP   A 1 170 ? -0.67572  -5.31614  35.97909  1.000 16.63254 ? 648 ASP   B OD1  1 
ATOM   2726 O OD2  . ASP   A 1 170 ? -0.79591  -5.18033  38.17293  1.000 13.65375 ? 648 ASP   B OD2  1 
ATOM   2727 H H    . ASP   A 1 170 ? 1.24642   -7.40701  38.19656  1.000 15.26730 ? 648 ASP   B H    1 
ATOM   2728 H HA   . ASP   A 1 170 ? 1.70892   -6.48660  35.72564  1.000 16.22831 ? 648 ASP   B HA   1 
ATOM   2729 H HB2  . ASP   A 1 170 ? 1.59318   -5.04188  38.12864  1.000 16.66244 ? 648 ASP   B HB2  1 
ATOM   2730 H HB3  . ASP   A 1 170 ? 1.65302   -4.38069  36.68480  1.000 16.66244 ? 648 ASP   B HB3  1 
ATOM   2731 N N    . SER   A 1 171 ? 4.15173   -6.71235  37.72273  1.000 13.27064 ? 649 SER   B N    1 
ATOM   2732 C CA   . SER   A 1 171 ? 5.60007   -6.64630  37.84912  1.000 12.23471 ? 649 SER   B CA   1 
ATOM   2733 C C    . SER   A 1 171 ? 6.03205   -7.72546  38.82748  1.000 13.11198 ? 649 SER   B C    1 
ATOM   2734 O O    . SER   A 1 171 ? 5.19683   -8.40102  39.40585  1.000 14.07644 ? 649 SER   B O    1 
ATOM   2735 C CB   . SER   A 1 171 ? 6.04167   -5.26726  38.31834  1.000 11.87905 ? 649 SER   B CB   1 
ATOM   2736 O OG   . SER   A 1 171 ? 5.68270   -5.01349  39.65219  1.000 13.62230 ? 649 SER   B OG   1 
ATOM   2737 H H    . SER   A 1 171 ? 3.76675   -7.07072  38.40314  1.000 15.87878 ? 649 SER   B H    1 
ATOM   2738 H HA   . SER   A 1 171 ? 6.00733   -6.82475  36.98703  1.000 14.63567 ? 649 SER   B HA   1 
ATOM   2739 H HB2  . SER   A 1 171 ? 7.00686   -5.20889  38.24144  1.000 14.20887 ? 649 SER   B HB2  1 
ATOM   2740 H HB3  . SER   A 1 171 ? 5.62283   -4.59951  37.75303  1.000 14.20887 ? 649 SER   B HB3  1 
ATOM   2741 H HG   . SER   A 1 171 ? 4.84798   -5.05295  39.73756  1.000 16.30078 ? 649 SER   B HG   1 
ATOM   2742 N N    . VAL   A 1 172 ? 7.34189   -7.88837  38.99168  1.000 13.08504 ? 650 VAL   B N    1 
ATOM   2743 C CA   . VAL   A 1 172 ? 7.88338   -8.75962  40.02492  1.000 13.71977 ? 650 VAL   B CA   1 
ATOM   2744 C C    . VAL   A 1 172 ? 8.90395   -8.00797  40.87117  1.000 13.64302 ? 650 VAL   B C    1 
ATOM   2745 O O    . VAL   A 1 172 ? 9.40036   -6.93666  40.50592  1.000 13.05320 ? 650 VAL   B O    1 
ATOM   2746 C CB   . VAL   A 1 172 ? 8.52288   -10.05765 39.45117  1.000 13.97280 ? 650 VAL   B CB   1 
ATOM   2747 C CG1  . VAL   A 1 172 ? 7.49513   -10.81187 38.60268  1.000 13.35309 ? 650 VAL   B CG1  1 
ATOM   2748 C CG2  . VAL   A 1 172 ? 9.75049   -9.75362  38.65012  1.000 12.97493 ? 650 VAL   B CG2  1 
ATOM   2749 H H    . VAL   A 1 172 ? 7.94062   -7.50043  38.51144  1.000 15.65607 ? 650 VAL   B H    1 
ATOM   2750 H HA   . VAL   A 1 172 ? 7.14832   -9.00956  40.60640  1.000 16.41773 ? 650 VAL   B HA   1 
ATOM   2751 H HB   . VAL   A 1 172 ? 8.79535   -10.62383 40.19016  1.000 16.72138 ? 650 VAL   B HB   1 
ATOM   2752 H HG11 . VAL   A 1 172 ? 7.89236   -11.63825 38.28613  1.000 15.97772 ? 650 VAL   B HG11 1 
ATOM   2753 H HG12 . VAL   A 1 172 ? 6.71708   -11.00658 39.14823  1.000 15.97772 ? 650 VAL   B HG12 1 
ATOM   2754 H HG13 . VAL   A 1 172 ? 7.24011   -10.25739 37.84875  1.000 15.97772 ? 650 VAL   B HG13 1 
ATOM   2755 H HG21 . VAL   A 1 172 ? 10.04855  -10.56446 38.20897  1.000 15.52393 ? 650 VAL   B HG21 1 
ATOM   2756 H HG22 . VAL   A 1 172 ? 9.53658   -9.07684  37.98898  1.000 15.52393 ? 650 VAL   B HG22 1 
ATOM   2757 H HG23 . VAL   A 1 172 ? 10.44324  -9.42717  39.24546  1.000 15.52393 ? 650 VAL   B HG23 1 
ATOM   2758 N N    . THR   A 1 173 ? 9.21747   -8.60650  42.01050  1.000 13.27406 ? 651 THR   B N    1 
ATOM   2759 C CA   . THR   A 1 173 ? 10.11209  -8.01669  42.98259  1.000 13.51669 ? 651 THR   B CA   1 
ATOM   2760 C C    . THR   A 1 173 ? 11.05309  -9.06218  43.52633  1.000 15.37920 ? 651 THR   B C    1 
ATOM   2761 O O    . THR   A 1 173 ? 10.94646  -10.25688 43.22937  1.000 16.04705 ? 651 THR   B O    1 
ATOM   2762 C CB   . THR   A 1 173 ? 9.31769   -7.35609  44.10933  1.000 14.11311 ? 651 THR   B CB   1 
ATOM   2763 O OG1  . THR   A 1 173 ? 10.18129  -6.62476  44.98829  1.000 15.08172 ? 651 THR   B OG1  1 
ATOM   2764 C CG2  . THR   A 1 173 ? 8.57071   -8.39755  44.92252  1.000 16.30262 ? 651 THR   B CG2  1 
ATOM   2765 H H    . THR   A 1 173 ? 8.91452   -9.37602  42.24643  1.000 15.88288 ? 651 THR   B H    1 
ATOM   2766 H HA   . THR   A 1 173 ? 10.66092  -7.34621  42.54652  1.000 16.17404 ? 651 THR   B HA   1 
ATOM   2767 H HB   . THR   A 1 173 ? 8.68033   -6.74387  43.70951  1.000 16.88975 ? 651 THR   B HB   1 
ATOM   2768 H HG1  . THR   A 1 173 ? 10.57815  -6.01898  44.56270  1.000 18.05208 ? 651 THR   B HG1  1 
ATOM   2769 H HG21 . THR   A 1 173 ? 7.93774   -7.96376  45.51589  1.000 19.51716 ? 651 THR   B HG21 1 
ATOM   2770 H HG22 . THR   A 1 173 ? 8.08844   -8.99668  44.33145  1.000 19.51716 ? 651 THR   B HG22 1 
ATOM   2771 H HG23 . THR   A 1 173 ? 9.19613   -8.91510  45.45344  1.000 19.51716 ? 651 THR   B HG23 1 
ATOM   2772 N N    . ASN   A 1 174 ? 12.00984  -8.60243  44.33973  1.000 15.85361 ? 652 ASN   B N    1 
ATOM   2773 C CA   . ASN   A 1 174 ? 12.91131  -9.54931  44.99253  1.000 16.44720 ? 652 ASN   B CA   1 
ATOM   2774 C C    . ASN   A 1 174 ? 12.30453  -10.16333 46.24165  1.000 18.31875 ? 652 ASN   B C    1 
ATOM   2775 O O    . ASN   A 1 174 ? 12.68518  -11.26126 46.62584  1.000 18.45392 ? 652 ASN   B O    1 
ATOM   2776 C CB   . ASN   A 1 174 ? 14.22245  -8.85923  45.36775  1.000 18.21695 ? 652 ASN   B CB   1 
ATOM   2777 C CG   . ASN   A 1 174 ? 14.02780  -7.80281  46.42007  1.000 17.98368 ? 652 ASN   B CG   1 
ATOM   2778 O OD1  . ASN   A 1 174 ? 13.24676  -6.88577  46.25151  1.000 15.16396 ? 652 ASN   B OD1  1 
ATOM   2779 N ND2  . ASN   A 1 174 ? 14.72045  -7.94790  47.53261  1.000 20.10480 ? 652 ASN   B ND2  1 
ATOM   2780 H H    . ASN   A 1 174 ? 12.15095  -7.77396  44.52230  1.000 18.97834 ? 652 ASN   B H    1 
ATOM   2781 H HA   . ASN   A 1 174 ? 13.11141  -10.26209 44.36579  1.000 19.69065 ? 652 ASN   B HA   1 
ATOM   2782 H HB2  . ASN   A 1 174 ? 14.84220  -9.52022  45.71402  1.000 21.81435 ? 652 ASN   B HB2  1 
ATOM   2783 H HB3  . ASN   A 1 174 ? 14.59591  -8.43527  44.57928  1.000 21.81435 ? 652 ASN   B HB3  1 
ATOM   2784 H HD21 . ASN   A 1 174 ? 14.64417  -7.37016  48.16507  1.000 24.07978 ? 652 ASN   B HD21 1 
ATOM   2785 H HD22 . ASN   A 1 174 ? 15.24849  -8.62027  47.62580  1.000 24.07978 ? 652 ASN   B HD22 1 
ATOM   2786 N N    . ASN   A 1 175 ? 11.36250  -9.49326  46.86575  1.000 18.98075 ? 653 ASN   B N    1 
ATOM   2787 C CA   . ASN   A 1 175 ? 10.82688  -9.85353  48.17222  1.000 21.71751 ? 653 ASN   B CA   1 
ATOM   2788 C C    . ASN   A 1 175 ? 9.53191   -9.08399  48.39193  1.000 21.74475 ? 653 ASN   B C    1 
ATOM   2789 O O    . ASN   A 1 175 ? 9.55590   -7.85358  48.49120  1.000 20.40172 ? 653 ASN   B O    1 
ATOM   2790 C CB   . ASN   A 1 175 ? 11.85248  -9.52683  49.26556  1.000 23.84767 ? 653 ASN   B CB   1 
ATOM   2791 C CG   . ASN   A 1 175 ? 11.37664  -9.93929  50.66616  1.000 28.77262 ? 653 ASN   B CG   1 
ATOM   2792 O OD1  . ASN   A 1 175 ? 10.19753  -9.90166  50.97204  1.000 33.02683 ? 653 ASN   B OD1  1 
ATOM   2793 N ND2  . ASN   A 1 175 ? 12.31598  -10.28278 51.51950  1.000 34.82092 ? 653 ASN   B ND2  1 
ATOM   2794 H H    . ASN   A 1 175 ? 10.99220  -8.78735  46.54299  1.000 22.73092 ? 653 ASN   B H    1 
ATOM   2795 H HA   . ASN   A 1 175 ? 10.64297  -10.80452 48.22416  1.000 26.01502 ? 653 ASN   B HA   1 
ATOM   2796 H HB2  . ASN   A 1 175 ? 12.67761  -10.00072 49.07714  1.000 28.57122 ? 653 ASN   B HB2  1 
ATOM   2797 H HB3  . ASN   A 1 175 ? 12.01346  -8.57031  49.27273  1.000 28.57122 ? 653 ASN   B HB3  1 
ATOM   2798 H HD21 . ASN   A 1 175 ? 12.10481  -10.52243 52.31798  1.000 41.73912 ? 653 ASN   B HD21 1 
ATOM   2799 H HD22 . ASN   A 1 175 ? 13.14159  -10.26782 51.27920  1.000 41.73912 ? 653 ASN   B HD22 1 
ATOM   2800 N N    . THR   A 1 176 ? 8.38305   -9.78656  48.46974  1.000 23.23476 ? 654 THR   B N    1 
ATOM   2801 C CA   . THR   A 1 176 ? 7.11494   -9.07319  48.54231  1.000 24.36066 ? 654 THR   B CA   1 
ATOM   2802 C C    . THR   A 1 176 ? 6.91846   -8.40166  49.89529  1.000 25.83850 ? 654 THR   B C    1 
ATOM   2803 O O    . THR   A 1 176 ? 6.26158   -7.35827  49.97631  1.000 27.49540 ? 654 THR   B O    1 
ATOM   2804 C CB   . THR   A 1 176 ? 5.94819   -10.02082 48.24306  1.000 30.80997 ? 654 THR   B CB   1 
ATOM   2805 O OG1  . THR   A 1 176 ? 5.92631   -11.09242 49.19541  1.000 36.49731 ? 654 THR   B OG1  1 
ATOM   2806 C CG2  . THR   A 1 176 ? 6.08874   -10.60018 46.85123  1.000 25.76296 ? 654 THR   B CG2  1 
ATOM   2807 H H    . THR   A 1 176 ? 8.32349   -10.64442 48.48112  1.000 27.83573 ? 654 THR   B H    1 
ATOM   2808 H HA   . THR   A 1 176 ? 7.11558   -8.38109  47.86269  1.000 29.18681 ? 654 THR   B HA   1 
ATOM   2809 H HB   . THR   A 1 176 ? 5.11435   -9.52824  48.29765  1.000 36.92598 ? 654 THR   B HB   1 
ATOM   2810 H HG1  . THR   A 1 176 ? 6.63993   -11.53304 49.14855  1.000 43.75079 ? 654 THR   B HG1  1 
ATOM   2811 H HG21 . THR   A 1 176 ? 5.31926   -11.15270 46.64260  1.000 30.86957 ? 654 THR   B HG21 1 
ATOM   2812 H HG22 . THR   A 1 176 ? 6.14896   -9.88500  46.19870  1.000 30.86957 ? 654 THR   B HG22 1 
ATOM   2813 H HG23 . THR   A 1 176 ? 6.89039   -11.14366 46.79750  1.000 30.86957 ? 654 THR   B HG23 1 
ATOM   2814 N N    . ARG   A 1 177 ? 7.50325   -8.96511  50.94865  1.000 26.11481 ? 655 ARG   B N    1 
ATOM   2815 C CA   . ARG   A 1 177 ? 7.40122   -8.37971  52.27952  1.000 33.78254 ? 655 ARG   B CA   1 
ATOM   2816 C C    . ARG   A 1 177 ? 8.22826   -7.10360  52.39414  1.000 27.92683 ? 655 ARG   B C    1 
ATOM   2817 O O    . ARG   A 1 177 ? 7.78396   -6.12694  53.00602  1.000 30.53715 ? 655 ARG   B O    1 
ATOM   2818 C CB   . ARG   A 1 177 ? 7.85355   -9.40333  53.32861  1.000 36.77277 ? 655 ARG   B CB   1 
ATOM   2819 C CG   . ARG   A 1 177 ? 6.88261   -10.55892 53.52730  1.000 45.24004 ? 655 ARG   B CG   1 
ATOM   2820 C CD   . ARG   A 1 177 ? 5.60968   -10.10824 54.23132  1.000 59.75302 ? 655 ARG   B CD   1 
ATOM   2821 N NE   . ARG   A 1 177 ? 4.54263   -11.09730 54.12023  1.000 77.84241 ? 655 ARG   B NE   1 
ATOM   2822 C CZ   . ARG   A 1 177 ? 4.39615   -12.14090 54.92595  1.000 80.47577 ? 655 ARG   B CZ   1 
ATOM   2823 N NH1  . ARG   A 1 177 ? 5.24651   -12.37680 55.91558  1.000 69.45644 ? 655 ARG   B NH1  1 
ATOM   2824 N NH2  . ARG   A 1 177 ? 3.37157   -12.96901 54.73266  1.000 77.25869 ? 655 ARG   B NH2  1 
ATOM   2825 H H    . ARG   A 1 177 ? 7.96652   -9.68909  50.91980  1.000 31.29178 ? 655 ARG   B H    1 
ATOM   2826 H HA   . ARG   A 1 177 ? 6.47427   -8.15037  52.45001  1.000 40.49306 ? 655 ARG   B HA   1 
ATOM   2827 H HB2  . ARG   A 1 177 ? 8.70430   -9.77748  53.05089  1.000 44.08134 ? 655 ARG   B HB2  1 
ATOM   2828 H HB3  . ARG   A 1 177 ? 7.95237   -8.95135  54.18117  1.000 44.08134 ? 655 ARG   B HB3  1 
ATOM   2829 H HG2  . ARG   A 1 177 ? 6.63880   -10.92527 52.66287  1.000 54.24207 ? 655 ARG   B HG2  1 
ATOM   2830 H HG3  . ARG   A 1 177 ? 7.30479   -11.24285 54.07035  1.000 54.24207 ? 655 ARG   B HG3  1 
ATOM   2831 H HD2  . ARG   A 1 177 ? 5.79768   -9.97020  55.17286  1.000 71.65764 ? 655 ARG   B HD2  1 
ATOM   2832 H HD3  . ARG   A 1 177 ? 5.29903   -9.28143  53.83034  1.000 71.65764 ? 655 ARG   B HD3  1 
ATOM   2833 H HE   . ARG   A 1 177 ? 3.96838   -10.99661 53.48801  1.000 93.36491 ? 655 ARG   B HE   1 
ATOM   2834 H HH11 . ARG   A 1 177 ? 5.91142   -11.84734 56.04660  1.000 83.30174 ? 655 ARG   B HH11 1 
ATOM   2835 H HH12 . ARG   A 1 177 ? 5.13314   -13.05928 56.42644  1.000 83.30174 ? 655 ARG   B HH12 1 
ATOM   2836 H HH21 . ARG   A 1 177 ? 2.81604   -12.82363 54.09247  1.000 92.66444 ? 655 ARG   B HH21 1 
ATOM   2837 H HH22 . ARG   A 1 177 ? 3.26535   -13.64926 55.24801  1.000 92.66444 ? 655 ARG   B HH22 1 
ATOM   2838 N N    . SER   A 1 178 ? 9.41492   -7.08446  51.79067  1.000 26.17152 ? 656 SER   B N    1 
ATOM   2839 C CA   . SER   A 1 178 ? 10.32985  -5.93828  51.86410  1.000 28.20621 ? 656 SER   B CA   1 
ATOM   2840 C C    . SER   A 1 178 ? 10.91271  -5.67344  50.48289  1.000 22.55075 ? 656 SER   B C    1 
ATOM   2841 O O    . SER   A 1 178 ? 12.07395  -5.97902  50.20549  1.000 20.96582 ? 656 SER   B O    1 
ATOM   2842 C CB   . SER   A 1 178 ? 11.43917  -6.18401  52.88229  1.000 29.83986 ? 656 SER   B CB   1 
ATOM   2843 O OG   . SER   A 1 178 ? 10.88756  -6.47488  54.16143  1.000 46.11930 ? 656 SER   B OG   1 
ATOM   2844 H H    . SER   A 1 178 ? 9.72209   -7.73655  51.32161  1.000 31.35984 ? 656 SER   B H    1 
ATOM   2845 H HA   . SER   A 1 178 ? 9.82513   -5.15709  52.13962  1.000 33.80146 ? 656 SER   B HA   1 
ATOM   2846 H HB2  . SER   A 1 178 ? 11.97642  -6.93696  52.59016  1.000 35.76185 ? 656 SER   B HB2  1 
ATOM   2847 H HB3  . SER   A 1 178 ? 11.99062  -5.38875  52.94833  1.000 35.76185 ? 656 SER   B HB3  1 
ATOM   2848 H HG   . SER   A 1 178 ? 11.50375  -6.61253  54.71547  1.000 55.29717 ? 656 SER   B HG   1 
ATOM   2849 N N    . PRO   A 1 179 ? 10.10455  -5.14972  49.56870  1.000 20.88249 ? 657 PRO   B N    1 
ATOM   2850 C CA   . PRO   A 1 179 ? 10.58248  -4.97760  48.19498  1.000 20.24471 ? 657 PRO   B CA   1 
ATOM   2851 C C    . PRO   A 1 179 ? 11.70183  -3.95494  48.14721  1.000 18.23298 ? 657 PRO   B C    1 
ATOM   2852 O O    . PRO   A 1 179 ? 11.59925  -2.87352  48.72865  1.000 19.55291 ? 657 PRO   B O    1 
ATOM   2853 C CB   . PRO   A 1 179 ? 9.34381   -4.49006  47.43094  1.000 19.17022 ? 657 PRO   B CB   1 
ATOM   2854 C CG   . PRO   A 1 179 ? 8.43388   -3.94020  48.48031  1.000 25.76289 ? 657 PRO   B CG   1 
ATOM   2855 C CD   . PRO   A 1 179 ? 8.68840   -4.76249  49.72517  1.000 24.55336 ? 657 PRO   B CD   1 
ATOM   2856 H HA   . PRO   A 1 179 ? 10.88056  -5.82265  47.82359  1.000 24.24766 ? 657 PRO   B HA   1 
ATOM   2857 H HB2  . PRO   A 1 179 ? 9.59724   -3.80194  46.79598  1.000 22.95828 ? 657 PRO   B HB2  1 
ATOM   2858 H HB3  . PRO   A 1 179 ? 8.92867   -5.23352  46.96636  1.000 22.95828 ? 657 PRO   B HB3  1 
ATOM   2859 H HG2  . PRO   A 1 179 ? 8.64324   -3.00618  48.63739  1.000 30.86949 ? 657 PRO   B HG2  1 
ATOM   2860 H HG3  . PRO   A 1 179 ? 7.51185   -4.02969  48.19264  1.000 30.86949 ? 657 PRO   B HG3  1 
ATOM   2861 H HD2  . PRO   A 1 179 ? 8.55925   -4.23080  50.52613  1.000 29.41805 ? 657 PRO   B HD2  1 
ATOM   2862 H HD3  . PRO   A 1 179 ? 8.11437   -5.54403  49.74964  1.000 29.41805 ? 657 PRO   B HD3  1 
ATOM   2863 N N    . LYS   A 1 180 ? 12.78299  -4.30942  47.46296  1.000 18.09749 ? 658 LYS   B N    1 
ATOM   2864 C CA   . LYS   A 1 180 ? 13.88692  -3.38803  47.22171  1.000 17.02443 ? 658 LYS   B CA   1 
ATOM   2865 C C    . LYS   A 1 180 ? 14.19243  -3.20138  45.74023  1.000 15.65859 ? 658 LYS   B C    1 
ATOM   2866 O O    . LYS   A 1 180 ? 14.85780  -2.23243  45.39452  1.000 16.98996 ? 658 LYS   B O    1 
ATOM   2867 C CB   . LYS   A 1 180 ? 15.14432  -3.86644  47.94226  1.000 19.70811 ? 658 LYS   B CB   1 
ATOM   2868 C CG   . LYS   A 1 180 ? 15.07629  -3.68997  49.44330  1.000 23.14557 ? 658 LYS   B CG   1 
ATOM   2869 C CD   . LYS   A 1 180 ? 15.15634  -2.20722  49.82558  1.000 27.01916 ? 658 LYS   B CD   1 
ATOM   2870 C CE   . LYS   A 1 180 ? 15.11517  -2.03992  51.35570  1.000 31.00110 ? 658 LYS   B CE   1 
ATOM   2871 N NZ   . LYS   A 1 180 ? 15.13442  -0.60424  51.73348  1.000 35.18619 ? 658 LYS   B NZ   1 
ATOM   2872 H H    . LYS   A 1 180 ? 12.90291  -5.09013  47.12281  1.000 21.67100 ? 658 LYS   B H    1 
ATOM   2873 H HA   . LYS   A 1 180 ? 13.66734  -2.51747  47.58889  1.000 20.38333 ? 658 LYS   B HA   1 
ATOM   2874 H HB2  . LYS   A 1 180 ? 15.27137  -4.81034  47.75836  1.000 23.60375 ? 658 LYS   B HB2  1 
ATOM   2875 H HB3  . LYS   A 1 180 ? 15.90459  -3.35971  47.61651  1.000 23.60375 ? 658 LYS   B HB3  1 
ATOM   2876 H HG2  . LYS   A 1 180 ? 14.23699  -4.04727  49.77316  1.000 27.72870 ? 658 LYS   B HG2  1 
ATOM   2877 H HG3  . LYS   A 1 180 ? 15.82027  -4.15450  49.85753  1.000 27.72870 ? 658 LYS   B HG3  1 
ATOM   2878 H HD2  . LYS   A 1 180 ? 15.98762  -1.83126  49.49614  1.000 32.37700 ? 658 LYS   B HD2  1 
ATOM   2879 H HD3  . LYS   A 1 180 ? 14.40248  -1.73188  49.44263  1.000 32.37700 ? 658 LYS   B HD3  1 
ATOM   2880 H HE2  . LYS   A 1 180 ? 14.30155  -2.43813  51.70260  1.000 37.15533 ? 658 LYS   B HE2  1 
ATOM   2881 H HE3  . LYS   A 1 180 ? 15.88967  -2.47162  51.74900  1.000 37.15533 ? 658 LYS   B HE3  1 
ATOM   2882 H HZ1  . LYS   A 1 180 ? 14.42821  -0.18860  51.38618  1.000 42.17744 ? 658 LYS   B HZ1  1 
ATOM   2883 H HZ2  . LYS   A 1 180 ? 15.11101  -0.52225  52.61938  1.000 42.17744 ? 658 LYS   B HZ2  1 
ATOM   2884 H HZ3  . LYS   A 1 180 ? 15.87587  -0.21880  51.42723  1.000 42.17744 ? 658 LYS   B HZ3  1 
ATOM   2885 N N    . LEU   A 1 181 ? 13.69475  -4.07330  44.85422  1.000 15.16738 ? 659 LEU   B N    1 
ATOM   2886 C CA   . LEU   A 1 181 ? 13.79179  -3.83529  43.42603  1.000 15.21608 ? 659 LEU   B CA   1 
ATOM   2887 C C    . LEU   A 1 181 ? 12.53337  -4.35483  42.73796  1.000 14.32109 ? 659 LEU   B C    1 
ATOM   2888 O O    . LEU   A 1 181 ? 11.83585  -5.23177  43.24888  1.000 15.03420 ? 659 LEU   B O    1 
ATOM   2889 C CB   . LEU   A 1 181 ? 15.01091  -4.50684  42.80808  1.000 17.47956 ? 659 LEU   B CB   1 
ATOM   2890 C CG   . LEU   A 1 181 ? 15.18874  -5.98643  42.90098  1.000 20.16223 ? 659 LEU   B CG   1 
ATOM   2891 C CD1  . LEU   A 1 181 ? 14.38987  -6.72377  41.83200  1.000 19.19247 ? 659 LEU   B CD1  1 
ATOM   2892 C CD2  . LEU   A 1 181 ? 16.72903  -6.30369  42.78920  1.000 20.05340 ? 659 LEU   B CD2  1 
ATOM   2893 H H    . LEU   A 1 181 ? 13.29825  -4.80687  45.06464  1.000 18.15487 ? 659 LEU   B H    1 
ATOM   2894 H HA   . LEU   A 1 181 ? 13.86150  -2.87955  43.27565  1.000 18.21332 ? 659 LEU   B HA   1 
ATOM   2895 H HB2  . LEU   A 1 181 ? 15.00190  -4.29728  41.86103  1.000 20.92949 ? 659 LEU   B HB2  1 
ATOM   2896 H HB3  . LEU   A 1 181 ? 15.79388  -4.11633  43.22685  1.000 20.92949 ? 659 LEU   B HB3  1 
ATOM   2897 H HG   . LEU   A 1 181 ? 14.85001  -6.30835  43.75100  1.000 24.14869 ? 659 LEU   B HG   1 
ATOM   2898 H HD11 . LEU   A 1 181 ? 14.74734  -7.62001  41.73263  1.000 22.98498 ? 659 LEU   B HD11 1 
ATOM   2899 H HD12 . LEU   A 1 181 ? 13.46036  -6.76688  42.10595  1.000 22.98498 ? 659 LEU   B HD12 1 
ATOM   2900 H HD13 . LEU   A 1 181 ? 14.46552  -6.24260  40.99316  1.000 22.98498 ? 659 LEU   B HD13 1 
ATOM   2901 H HD21 . LEU   A 1 181 ? 16.85519  -7.26535  42.80296  1.000 24.01809 ? 659 LEU   B HD21 1 
ATOM   2902 H HD22 . LEU   A 1 181 ? 17.06729  -5.93757  41.95707  1.000 24.01809 ? 659 LEU   B HD22 1 
ATOM   2903 H HD23 . LEU   A 1 181 ? 17.19018  -5.89879  43.54039  1.000 24.01809 ? 659 LEU   B HD23 1 
ATOM   2904 N N    . PHE   A 1 182 ? 12.24402  -3.77480  41.59580  1.000 12.89409 ? 660 PHE   B N    1 
ATOM   2905 C CA   . PHE   A 1 182 ? 11.09195  -4.20045  40.79761  1.000 14.21977 ? 660 PHE   B CA   1 
ATOM   2906 C C    . PHE   A 1 182 ? 11.54994  -4.40265  39.36983  1.000 13.80552 ? 660 PHE   B C    1 
ATOM   2907 O O    . PHE   A 1 182 ? 12.44950  -3.71184  38.88517  1.000 11.62418 ? 660 PHE   B O    1 
ATOM   2908 C CB   . PHE   A 1 182 ? 9.95682   -3.17956  40.84012  1.000 15.93186 ? 660 PHE   B CB   1 
ATOM   2909 C CG   . PHE   A 1 182 ? 9.26021   -3.10353  42.15357  1.000 13.44081 ? 660 PHE   B CG   1 
ATOM   2910 C CD1  . PHE   A 1 182 ? 9.68704   -2.26939  43.13402  1.000 13.51270 ? 660 PHE   B CD1  1 
ATOM   2911 C CD2  . PHE   A 1 182 ? 8.15313   -3.90875  42.40580  1.000 15.29383 ? 660 PHE   B CD2  1 
ATOM   2912 C CE1  . PHE   A 1 182 ? 9.06458   -2.19629  44.34568  1.000 17.07795 ? 660 PHE   B CE1  1 
ATOM   2913 C CE2  . PHE   A 1 182 ? 7.51787   -3.82404  43.63800  1.000 15.74238 ? 660 PHE   B CE2  1 
ATOM   2914 C CZ   . PHE   A 1 182 ? 7.96104   -2.96463  44.59028  1.000 16.72063 ? 660 PHE   B CZ   1 
ATOM   2915 H H    . PHE   A 1 182 ? 12.69513  -3.12876  41.25122  1.000 15.42692 ? 660 PHE   B H    1 
ATOM   2916 H HA   . PHE   A 1 182 ? 10.74118  -5.03692  41.14136  1.000 17.01774 ? 660 PHE   B HA   1 
ATOM   2917 H HB2  . PHE   A 1 182 ? 10.32105  -2.30131  40.64801  1.000 19.07225 ? 660 PHE   B HB2  1 
ATOM   2918 H HB3  . PHE   A 1 182 ? 9.29774   -3.41923  40.16999  1.000 19.07225 ? 660 PHE   B HB3  1 
ATOM   2919 H HD1  . PHE   A 1 182 ? 10.42778  -1.72996  42.97523  1.000 16.16925 ? 660 PHE   B HD1  1 
ATOM   2920 H HD2  . PHE   A 1 182 ? 7.84218   -4.49715  41.75620  1.000 18.30661 ? 660 PHE   B HD2  1 
ATOM   2921 H HE1  . PHE   A 1 182 ? 9.39024   -1.62520  45.00348  1.000 20.44755 ? 660 PHE   B HE1  1 
ATOM   2922 H HE2  . PHE   A 1 182 ? 6.78007   -4.36263  43.81257  1.000 18.84487 ? 660 PHE   B HE2  1 
ATOM   2923 H HZ   . PHE   A 1 182 ? 7.51645   -2.89891  45.40448  1.000 20.01877 ? 660 PHE   B HZ   1 
ATOM   2924 N N    . VAL   A 1 183 ? 10.95717  -5.38091  38.70245  1.000 12.42165 ? 661 VAL   B N    1 
ATOM   2925 C CA   . VAL   A 1 183 ? 11.27477  -5.68504  37.31603  1.000 12.83735 ? 661 VAL   B CA   1 
ATOM   2926 C C    . VAL   A 1 183 ? 9.99656   -5.52465  36.50581  1.000 12.95404 ? 661 VAL   B C    1 
ATOM   2927 O O    . VAL   A 1 183 ? 8.96034   -6.06423  36.89000  1.000 13.07778 ? 661 VAL   B O    1 
ATOM   2928 C CB   . VAL   A 1 183 ? 11.82891  -7.10277  37.15906  1.000 12.60335 ? 661 VAL   B CB   1 
ATOM   2929 C CG1  . VAL   A 1 183 ? 12.30447  -7.33169  35.70585  1.000 14.09822 ? 661 VAL   B CG1  1 
ATOM   2930 C CG2  . VAL   A 1 183 ? 12.99163  -7.36991  38.11712  1.000 14.17293 ? 661 VAL   B CG2  1 
ATOM   2931 H H    . VAL   A 1 183 ? 10.35432  -5.89358  39.03911  1.000 14.86000 ? 661 VAL   B H    1 
ATOM   2932 H HA   . VAL   A 1 183 ? 11.94048  -5.05899  36.99077  1.000 15.35883 ? 661 VAL   B HA   1 
ATOM   2933 H HB   . VAL   A 1 183 ? 11.11443  -7.72296  37.37303  1.000 15.07803 ? 661 VAL   B HB   1 
ATOM   2934 H HG11 . VAL   A 1 183 ? 12.73806  -8.19747  35.64815  1.000 16.87188 ? 661 VAL   B HG11 1 
ATOM   2935 H HG12 . VAL   A 1 183 ? 11.53603  -7.30652  35.11443  1.000 16.87188 ? 661 VAL   B HG12 1 
ATOM   2936 H HG13 . VAL   A 1 183 ? 12.93072  -6.63137  35.46448  1.000 16.87188 ? 661 VAL   B HG13 1 
ATOM   2937 H HG21 . VAL   A 1 183 ? 13.36180  -8.24629  37.92787  1.000 16.96153 ? 661 VAL   B HG21 1 
ATOM   2938 H HG22 . VAL   A 1 183 ? 13.67036  -6.68914  37.98758  1.000 16.96153 ? 661 VAL   B HG22 1 
ATOM   2939 H HG23 . VAL   A 1 183 ? 12.66267  -7.33970  39.02914  1.000 16.96153 ? 661 VAL   B HG23 1 
ATOM   2940 N N    . VAL   A 1 184 ? 10.07738  -4.78950  35.39228  1.000 13.62164 ? 662 VAL   B N    1 
ATOM   2941 C CA   . VAL   A 1 184 ? 8.96580   -4.67341  34.46182  1.000 15.12967 ? 662 VAL   B CA   1 
ATOM   2942 C C    . VAL   A 1 184 ? 9.38062   -5.20544  33.09865  1.000 13.71547 ? 662 VAL   B C    1 
ATOM   2943 O O    . VAL   A 1 184 ? 10.56219  -5.17064  32.72184  1.000 14.35166 ? 662 VAL   B O    1 
ATOM   2944 C CB   . VAL   A 1 184 ? 8.40520   -3.24259  34.32895  1.000 19.11422 ? 662 VAL   B CB   1 
ATOM   2945 C CG1  . VAL   A 1 184 ? 7.79798   -2.80617  35.65733  1.000 18.14539 ? 662 VAL   B CG1  1 
ATOM   2946 C CG2  . VAL   A 1 184 ? 9.44536   -2.33514  33.85458  1.000 21.66216 ? 662 VAL   B CG2  1 
ATOM   2947 H H    . VAL   A 1 184 ? 10.77598  -4.34639  35.15732  1.000 16.29998 ? 662 VAL   B H    1 
ATOM   2948 H HA   . VAL   A 1 184 ? 8.25203   -5.23151  34.80817  1.000 18.10962 ? 662 VAL   B HA   1 
ATOM   2949 H HB   . VAL   A 1 184 ? 7.69546   -3.21550  33.66833  1.000 22.89108 ? 662 VAL   B HB   1 
ATOM   2950 H HG11 . VAL   A 1 184 ? 7.43769   -1.91074  35.56086  1.000 21.72848 ? 662 VAL   B HG11 1 
ATOM   2951 H HG12 . VAL   A 1 184 ? 7.08976   -3.42344  35.89879  1.000 21.72848 ? 662 VAL   B HG12 1 
ATOM   2952 H HG13 . VAL   A 1 184 ? 8.48909   -2.81309  36.33793  1.000 21.72848 ? 662 VAL   B HG13 1 
ATOM   2953 H HG21 . VAL   A 1 184 ? 9.11045   -1.42543  33.88878  1.000 25.94861 ? 662 VAL   B HG21 1 
ATOM   2954 H HG22 . VAL   A 1 184 ? 10.22485  -2.42233  34.42527  1.000 25.94861 ? 662 VAL   B HG22 1 
ATOM   2955 H HG23 . VAL   A 1 184 ? 9.67591   -2.56864  32.94177  1.000 25.94861 ? 662 VAL   B HG23 1 
ATOM   2956 N N    . PHE   A 1 185 ? 8.38479   -5.72234  32.35856  1.000 13.18686 ? 663 PHE   B N    1 
ATOM   2957 C CA   . PHE   A 1 185 ? 8.63552   -6.48582  31.14735  1.000 14.43484 ? 663 PHE   B CA   1 
ATOM   2958 C C    . PHE   A 1 185 ? 7.93819   -5.91882  29.92129  1.000 16.14090 ? 663 PHE   B C    1 
ATOM   2959 O O    . PHE   A 1 185 ? 7.95867   -6.54679  28.86133  1.000 14.84288 ? 663 PHE   B O    1 
ATOM   2960 C CB   . PHE   A 1 185 ? 8.18341   -7.94188  31.35391  1.000 15.79785 ? 663 PHE   B CB   1 
ATOM   2961 C CG   . PHE   A 1 185 ? 8.79435   -8.61832  32.55574  1.000 16.82269 ? 663 PHE   B CG   1 
ATOM   2962 C CD1  . PHE   A 1 185 ? 8.29402   -8.41108  33.81799  1.000 16.63039 ? 663 PHE   B CD1  1 
ATOM   2963 C CD2  . PHE   A 1 185 ? 9.86453   -9.49720  32.40273  1.000 14.79653 ? 663 PHE   B CD2  1 
ATOM   2964 C CE1  . PHE   A 1 185 ? 8.85510   -9.06747  34.91774  1.000 16.76182 ? 663 PHE   B CE1  1 
ATOM   2965 C CE2  . PHE   A 1 185 ? 10.42613  -10.12804 33.48993  1.000 14.88097 ? 663 PHE   B CE2  1 
ATOM   2966 C CZ   . PHE   A 1 185 ? 9.92586   -9.92854  34.74276  1.000 15.47042 ? 663 PHE   B CZ   1 
ATOM   2967 H H    . PHE   A 1 185 ? 7.55027   -5.63762  32.54827  1.000 15.77824 ? 663 PHE   B H    1 
ATOM   2968 H HA   . PHE   A 1 185 ? 9.58939   -6.46652  30.97223  1.000 17.27582 ? 663 PHE   B HA   1 
ATOM   2969 H HB2  . PHE   A 1 185 ? 7.22027   -7.95368  31.46850  1.000 18.91143 ? 663 PHE   B HB2  1 
ATOM   2970 H HB3  . PHE   A 1 185 ? 8.43057   -8.45695  30.57000  1.000 18.91143 ? 663 PHE   B HB3  1 
ATOM   2971 H HD1  . PHE   A 1 185 ? 7.57791   -7.83079  33.94191  1.000 19.91048 ? 663 PHE   B HD1  1 
ATOM   2972 H HD2  . PHE   A 1 185 ? 10.20489  -9.66028  31.55276  1.000 17.70985 ? 663 PHE   B HD2  1 
ATOM   2973 H HE1  . PHE   A 1 185 ? 8.50843   -8.92554  35.76896  1.000 20.06819 ? 663 PHE   B HE1  1 
ATOM   2974 H HE2  . PHE   A 1 185 ? 11.15311  -10.69526 33.36888  1.000 17.81118 ? 663 PHE   B HE2  1 
ATOM   2975 H HZ   . PHE   A 1 185 ? 10.30011  -10.36652 35.47283  1.000 18.51852 ? 663 PHE   B HZ   1 
ATOM   2976 N N    . PHE   A 1 186 ? 7.33578   -4.73394  30.02630  1.000 16.26782 ? 664 PHE   B N    1 
ATOM   2977 C CA   . PHE   A 1 186 ? 6.64860   -4.16129  28.88242  1.000 18.25179 ? 664 PHE   B CA   1 
ATOM   2978 C C    . PHE   A 1 186 ? 7.04538   -2.71975  28.67434  1.000 15.44577 ? 664 PHE   B C    1 
ATOM   2979 O O    . PHE   A 1 186 ? 7.45745   -2.02456  29.60909  1.000 15.96528 ? 664 PHE   B O    1 
ATOM   2980 C CB   . PHE   A 1 186 ? 5.12152   -4.27975  29.06506  1.000 17.21105 ? 664 PHE   B CB   1 
ATOM   2981 C CG   . PHE   A 1 186 ? 4.63310   -5.68673  29.08711  1.000 18.22244 ? 664 PHE   B CG   1 
ATOM   2982 C CD1  . PHE   A 1 186 ? 4.52609   -6.40834  27.91005  1.000 20.92579 ? 664 PHE   B CD1  1 
ATOM   2983 C CD2  . PHE   A 1 186 ? 4.29312   -6.30397  30.26838  1.000 19.52953 ? 664 PHE   B CD2  1 
ATOM   2984 C CE1  . PHE   A 1 186 ? 4.06041   -7.72182  27.92335  1.000 25.24958 ? 664 PHE   B CE1  1 
ATOM   2985 C CE2  . PHE   A 1 186 ? 3.81876   -7.60641  30.28605  1.000 22.61408 ? 664 PHE   B CE2  1 
ATOM   2986 C CZ   . PHE   A 1 186 ? 3.70866   -8.31372  29.11035  1.000 26.53306 ? 664 PHE   B CZ   1 
ATOM   2987 H H    . PHE   A 1 186 ? 7.31501   -4.25513  30.74038  1.000 19.47540 ? 664 PHE   B H    1 
ATOM   2988 H HA   . PHE   A 1 186 ? 6.91066   -4.63235  28.07599  1.000 21.85616 ? 664 PHE   B HA   1 
ATOM   2989 H HB2  . PHE   A 1 186 ? 4.87412   -3.86615  29.90686  1.000 20.60727 ? 664 PHE   B HB2  1 
ATOM   2990 H HB3  . PHE   A 1 186 ? 4.68226   -3.82426  28.32989  1.000 20.60727 ? 664 PHE   B HB3  1 
ATOM   2991 H HD1  . PHE   A 1 186 ? 4.76710   -6.01294  27.10353  1.000 25.06496 ? 664 PHE   B HD1  1 
ATOM   2992 H HD2  . PHE   A 1 186 ? 4.38303   -5.83950  31.06906  1.000 23.38946 ? 664 PHE   B HD2  1 
ATOM   2993 H HE1  . PHE   A 1 186 ? 3.98803   -8.19738  27.12742  1.000 30.25352 ? 664 PHE   B HE1  1 
ATOM   2994 H HE2  . PHE   A 1 186 ? 3.57509   -8.00202  31.09167  1.000 27.09091 ? 664 PHE   B HE2  1 
ATOM   2995 H HZ   . PHE   A 1 186 ? 3.39691   -9.18985  29.12042  1.000 31.79368 ? 664 PHE   B HZ   1 
ATOM   2996 N N    . ASP   A 1 187 ? 6.96163   -2.29073  27.41463  1.000 15.54172 ? 665 ASP   B N    1 
ATOM   2997 C CA   . ASP   A 1 187 ? 7.22987   -0.89184  27.08213  1.000 16.94480 ? 665 ASP   B CA   1 
ATOM   2998 C C    . ASP   A 1 187 ? 6.17367   0.02762   27.69572  1.000 17.39291 ? 665 ASP   B C    1 
ATOM   2999 O O    . ASP   A 1 187 ? 5.01617   -0.35604  27.92193  1.000 16.50781 ? 665 ASP   B O    1 
ATOM   3000 C CB   . ASP   A 1 187 ? 7.23582   -0.70517  25.56992  1.000 17.70802 ? 665 ASP   B CB   1 
ATOM   3001 C CG   . ASP   A 1 187 ? 8.27491   -1.57770  24.88068  1.000 19.74764 ? 665 ASP   B CG   1 
ATOM   3002 O OD1  . ASP   A 1 187 ? 9.39947   -1.69596  25.40565  1.000 19.01122 ? 665 ASP   B OD1  1 
ATOM   3003 O OD2  . ASP   A 1 187 ? 7.95429   -2.11507  23.82290  1.000 19.81384 ? 665 ASP   B OD2  1 
ATOM   3004 H H    . ASP   A 1 187 ? 6.75372   -2.78389  26.74145  1.000 18.60408 ? 665 ASP   B H    1 
ATOM   3005 H HA   . ASP   A 1 187 ? 8.09813   -0.64207  27.43519  1.000 20.28777 ? 665 ASP   B HA   1 
ATOM   3006 H HB2  . ASP   A 1 187 ? 6.36324   -0.94071  25.21773  1.000 21.20364 ? 665 ASP   B HB2  1 
ATOM   3007 H HB3  . ASP   A 1 187 ? 7.43704   0.22142   25.36541  1.000 21.20364 ? 665 ASP   B HB3  1 
ATOM   3008 N N    . ASN   A 1 188 ? 6.59902   1.24082   27.99290  1.000 16.38044 ? 666 ASN   B N    1 
ATOM   3009 C CA   . ASN   A 1 188 ? 5.69222   2.28418   28.47131  1.000 18.61042 ? 666 ASN   B CA   1 
ATOM   3010 C C    . ASN   A 1 188 ? 5.09376   1.95184   29.82917  1.000 17.43873 ? 666 ASN   B C    1 
ATOM   3011 O O    . ASN   A 1 188 ? 4.05072   2.47724   30.20471  1.000 15.75873 ? 666 ASN   B O    1 
ATOM   3012 C CB   . ASN   A 1 188 ? 4.59144   2.55842   27.43190  1.000 19.52289 ? 666 ASN   B CB   1 
ATOM   3013 C CG   . ASN   A 1 188 ? 5.14417   2.80214   26.04453  1.000 20.49255 ? 666 ASN   B CG   1 
ATOM   3014 O OD1  . ASN   A 1 188 ? 4.80515   2.06941   25.09173  1.000 24.04188 ? 666 ASN   B OD1  1 
ATOM   3015 N ND2  . ASN   A 1 188 ? 6.01702   3.79259   25.91792  1.000 20.85413 ? 666 ASN   B ND2  1 
ATOM   3016 H H    . ASN   A 1 188 ? 7.41842   1.49341   27.92681  1.000 19.61054 ? 666 ASN   B H    1 
ATOM   3017 H HA   . ASN   A 1 188 ? 6.19565   3.10454   28.59162  1.000 22.28652 ? 666 ASN   B HA   1 
ATOM   3018 H HB2  . ASN   A 1 188 ? 3.99949   1.79121   27.38845  1.000 23.38148 ? 666 ASN   B HB2  1 
ATOM   3019 H HB3  . ASN   A 1 188 ? 4.09360   3.34684   27.69922  1.000 23.38148 ? 666 ASN   B HB3  1 
ATOM   3020 H HD21 . ASN   A 1 188 ? 6.35858   3.96902   25.14863  1.000 24.97897 ? 666 ASN   B HD21 1 
ATOM   3021 H HD22 . ASN   A 1 188 ? 6.24146   4.25842   26.60511  1.000 24.97897 ? 666 ASN   B HD22 1 
ATOM   3022 N N    . GLN   A 1 189 ? 5.74940   1.08902   30.59911  1.000 14.66050 ? 667 GLN   B N    1 
ATOM   3023 C CA   . GLN   A 1 189 ? 5.35650   0.81281   31.97089  1.000 13.50474 ? 667 GLN   B CA   1 
ATOM   3024 C C    . GLN   A 1 189 ? 6.17284   1.63895   32.96583  1.000 14.21669 ? 667 GLN   B C    1 
ATOM   3025 O O    . GLN   A 1 189 ? 6.00001   1.49674   34.18966  1.000 13.33939 ? 667 GLN   B O    1 
ATOM   3026 C CB   . GLN   A 1 189 ? 5.51158   -0.69351  32.26262  1.000 16.41621 ? 667 GLN   B CB   1 
ATOM   3027 C CG   . GLN   A 1 189 ? 4.53167   -1.20141  33.28678  1.000 17.47524 ? 667 GLN   B CG   1 
ATOM   3028 C CD   . GLN   A 1 189 ? 4.55763   -2.69945  33.46934  1.000 18.08203 ? 667 GLN   B CD   1 
ATOM   3029 O OE1  . GLN   A 1 189 ? 4.79272   -3.47057  32.52939  1.000 17.29196 ? 667 GLN   B OE1  1 
ATOM   3030 N NE2  . GLN   A 1 189 ? 4.33847   -3.11378  34.68954  1.000 14.18416 ? 667 GLN   B NE2  1 
ATOM   3031 H H    . GLN   A 1 189 ? 6.43859   0.64369   30.34161  1.000 17.54661 ? 667 GLN   B H    1 
ATOM   3032 H HA   . GLN   A 1 189 ? 4.42027   1.03187   32.09890  1.000 16.15970 ? 667 GLN   B HA   1 
ATOM   3033 H HB2  . GLN   A 1 189 ? 5.36890   -1.18902  31.44103  1.000 19.65347 ? 667 GLN   B HB2  1 
ATOM   3034 H HB3  . GLN   A 1 189 ? 6.40671   -0.85809  32.59812  1.000 19.65347 ? 667 GLN   B HB3  1 
ATOM   3035 H HG2  . GLN   A 1 189 ? 4.73848   -0.79633  34.14354  1.000 20.92430 ? 667 GLN   B HG2  1 
ATOM   3036 H HG3  . GLN   A 1 189 ? 3.63556   -0.95354  33.01029  1.000 20.92430 ? 667 GLN   B HG3  1 
ATOM   3037 H HE21 . GLN   A 1 189 ? 4.19366   -2.54434  35.31752  1.000 16.97501 ? 667 GLN   B HE21 1 
ATOM   3038 H HE22 . GLN   A 1 189 ? 4.33909   -3.95582  34.86436  1.000 16.97501 ? 667 GLN   B HE22 1 
ATOM   3039 N N    . ALA   A 1 190 ? 7.09385   2.46123   32.46312  1.000 12.38091 ? 668 ALA   B N    1 
ATOM   3040 C CA   . ALA   A 1 190 ? 7.97372   3.24954   33.32820  1.000 15.39542 ? 668 ALA   B CA   1 
ATOM   3041 C C    . ALA   A 1 190 ? 8.24401   4.55269   32.58964  1.000 16.93780 ? 668 ALA   B C    1 
ATOM   3042 O O    . ALA   A 1 190 ? 8.62735   4.51707   31.41351  1.000 18.97292 ? 668 ALA   B O    1 
ATOM   3043 C CB   . ALA   A 1 190 ? 9.28171   2.52103   33.63208  1.000 15.80379 ? 668 ALA   B CB   1 
ATOM   3044 H H    . ALA   A 1 190 ? 7.22969   2.58094   31.62240  1.000 14.81110 ? 668 ALA   B H    1 
ATOM   3045 H HA   . ALA   A 1 190 ? 7.54779   3.42812   34.18119  1.000 18.42852 ? 668 ALA   B HA   1 
ATOM   3046 H HB1  . ALA   A 1 190 ? 9.82455   3.07602   34.21365  1.000 18.91856 ? 668 ALA   B HB1  1 
ATOM   3047 H HB2  . ALA   A 1 190 ? 9.08009   1.67995   34.07121  1.000 18.91856 ? 668 ALA   B HB2  1 
ATOM   3048 H HB3  . ALA   A 1 190 ? 9.75164   2.35536   32.79984  1.000 18.91856 ? 668 ALA   B HB3  1 
ATOM   3049 N N    . TYR   A 1 191 ? 8.06369   5.68096   33.27910  1.000 13.31506 ? 669 TYR   B N    1 
ATOM   3050 C CA   . TYR   A 1 191 ? 8.29064   7.00112   32.68898  1.000 13.27192 ? 669 TYR   B CA   1 
ATOM   3051 C C    . TYR   A 1 191 ? 9.50737   7.63531   33.34362  1.000 13.70704 ? 669 TYR   B C    1 
ATOM   3052 O O    . TYR   A 1 191 ? 9.48076   7.83692   34.56211  1.000 12.41911 ? 669 TYR   B O    1 
ATOM   3053 C CB   . TYR   A 1 191 ? 7.07283   7.90407   32.87979  1.000 13.64409 ? 669 TYR   B CB   1 
ATOM   3054 C CG   . TYR   A 1 191 ? 7.32218   9.26766   32.29254  1.000 12.56522 ? 669 TYR   B CG   1 
ATOM   3055 C CD1  . TYR   A 1 191 ? 7.27224   9.45946   30.91885  1.000 14.26960 ? 669 TYR   B CD1  1 
ATOM   3056 C CD2  . TYR   A 1 191 ? 7.71009   10.32728  33.08565  1.000 12.61053 ? 669 TYR   B CD2  1 
ATOM   3057 C CE1  . TYR   A 1 191 ? 7.54313   10.67658  30.34149  1.000 15.14356 ? 669 TYR   B CE1  1 
ATOM   3058 C CE2  . TYR   A 1 191 ? 8.00990   11.57490  32.50982  1.000 13.49256 ? 669 TYR   B CE2  1 
ATOM   3059 C CZ   . TYR   A 1 191 ? 7.92613   11.74253  31.14550  1.000 16.25465 ? 669 TYR   B CZ   1 
ATOM   3060 O OH   . TYR   A 1 191 ? 8.24919   12.94760  30.53207  1.000 14.28154 ? 669 TYR   B OH   1 
ATOM   3061 H H    . TYR   A 1 191 ? 7.80731   5.70787   34.09956  1.000 15.93209 ? 669 TYR   B H    1 
ATOM   3062 H HA   . TYR   A 1 191 ? 8.45070   6.89961   31.73768  1.000 15.88032 ? 669 TYR   B HA   1 
ATOM   3063 H HB2  . TYR   A 1 191 ? 6.30610   7.51141   32.43387  1.000 16.32693 ? 669 TYR   B HB2  1 
ATOM   3064 H HB3  . TYR   A 1 191 ? 6.89010   8.00463   33.82710  1.000 16.32693 ? 669 TYR   B HB3  1 
ATOM   3065 H HD1  . TYR   A 1 191 ? 7.04835   8.74146   30.37182  1.000 17.07753 ? 669 TYR   B HD1  1 
ATOM   3066 H HD2  . TYR   A 1 191 ? 7.77379   10.21609  34.00678  1.000 15.08665 ? 669 TYR   B HD2  1 
ATOM   3067 H HE1  . TYR   A 1 191 ? 7.47068   10.78567  29.42075  1.000 18.12628 ? 669 TYR   B HE1  1 
ATOM   3068 H HE2  . TYR   A 1 191 ? 8.26488   12.28714  33.05074  1.000 16.14509 ? 669 TYR   B HE2  1 
ATOM   3069 H HH   . TYR   A 1 191 ? 8.48350   13.51041  31.10995  1.000 17.09186 ? 669 TYR   B HH   1 
ATOM   3070 N N    . PRO   A 1 192 ? 10.58589  7.88099   32.61428  1.000 12.74066 ? 670 PRO   B N    1 
ATOM   3071 C CA   . PRO   A 1 192 ? 11.76835  8.55473   33.20694  1.000 13.02994 ? 670 PRO   B CA   1 
ATOM   3072 C C    . PRO   A 1 192 ? 11.39731  9.99707   33.48838  1.000 13.72379 ? 670 PRO   B C    1 
ATOM   3073 O O    . PRO   A 1 192 ? 11.20110  10.75362  32.54183  1.000 14.93163 ? 670 PRO   B O    1 
ATOM   3074 C CB   . PRO   A 1 192 ? 12.83094  8.45320   32.12212  1.000 14.30005 ? 670 PRO   B CB   1 
ATOM   3075 C CG   . PRO   A 1 192 ? 12.06754  8.39263   30.84293  1.000 15.09852 ? 670 PRO   B CG   1 
ATOM   3076 C CD   . PRO   A 1 192 ? 10.76260  7.67698   31.15954  1.000 14.10301 ? 670 PRO   B CD   1 
ATOM   3077 H HA   . PRO   A 1 192 ? 12.10677  8.10096   33.99463  1.000 15.58994 ? 670 PRO   B HA   1 
ATOM   3078 H HB2  . PRO   A 1 192 ? 13.40511  9.23460   32.14756  1.000 17.11408 ? 670 PRO   B HB2  1 
ATOM   3079 H HB3  . PRO   A 1 192 ? 13.35861  7.64945   32.25037  1.000 17.11408 ? 670 PRO   B HB3  1 
ATOM   3080 H HG2  . PRO   A 1 192 ? 11.89559  9.29224   30.52351  1.000 18.07224 ? 670 PRO   B HG2  1 
ATOM   3081 H HG3  . PRO   A 1 192 ? 12.57753  7.89792   30.18257  1.000 18.07224 ? 670 PRO   B HG3  1 
ATOM   3082 H HD2  . PRO   A 1 192 ? 10.02680  8.07233   30.66640  1.000 16.87762 ? 670 PRO   B HD2  1 
ATOM   3083 H HD3  . PRO   A 1 192 ? 10.83121  6.73192   30.95208  1.000 16.87762 ? 670 PRO   B HD3  1 
ATOM   3084 N N    . GLU   A 1 193 ? 11.24840  10.36329  34.76127  1.000 12.72666 ? 671 GLU   B N    1 
ATOM   3085 C CA   . GLU   A 1 193 ? 10.76147  11.68499  35.11340  1.000 14.02970 ? 671 GLU   B CA   1 
ATOM   3086 C C    . GLU   A 1 193 ? 11.86934  12.69342  35.42572  1.000 13.34600 ? 671 GLU   B C    1 
ATOM   3087 O O    . GLU   A 1 193 ? 11.71842  13.87387  35.11108  1.000 13.71144 ? 671 GLU   B O    1 
ATOM   3088 C CB   . GLU   A 1 193 ? 9.83386   11.58774  36.31287  1.000 13.49145 ? 671 GLU   B CB   1 
ATOM   3089 C CG   . GLU   A 1 193 ? 9.06075   12.85737  36.56864  1.000 15.17582 ? 671 GLU   B CG   1 
ATOM   3090 C CD   . GLU   A 1 193 ? 8.00273   12.72441  37.69631  1.000 17.85988 ? 671 GLU   B CD   1 
ATOM   3091 O OE1  . GLU   A 1 193 ? 7.97524   11.69365  38.43023  1.000 19.86128 ? 671 GLU   B OE1  1 
ATOM   3092 O OE2  . GLU   A 1 193 ? 7.20757   13.66674  37.84199  1.000 21.35585 ? 671 GLU   B OE2  1 
ATOM   3093 H H    . GLU   A 1 193 ? 11.42450  9.85919   35.43542  1.000 15.22601 ? 671 GLU   B H    1 
ATOM   3094 H HA   . GLU   A 1 193 ? 10.26206  12.03262  34.35800  1.000 16.78966 ? 671 GLU   B HA   1 
ATOM   3095 H HB2  . GLU   A 1 193 ? 9.19465   10.87461  36.15873  1.000 16.14375 ? 671 GLU   B HB2  1 
ATOM   3096 H HB3  . GLU   A 1 193 ? 10.36174  11.39495  37.10349  1.000 16.14375 ? 671 GLU   B HB3  1 
ATOM   3097 H HG2  . GLU   A 1 193 ? 9.68260   13.55568  36.82662  1.000 18.16500 ? 671 GLU   B HG2  1 
ATOM   3098 H HG3  . GLU   A 1 193 ? 8.59669   13.11027  35.75526  1.000 18.16500 ? 671 GLU   B HG3  1 
ATOM   3099 N N    . TYR   A 1 194 ? 12.92717  12.27282  36.10892  1.000 13.15623 ? 672 TYR   B N    1 
ATOM   3100 C CA   . TYR   A 1 194 ? 14.04158  13.14839  36.46217  1.000 11.79153 ? 672 TYR   B CA   1 
ATOM   3101 C C    . TYR   A 1 194 ? 15.34027  12.42215  36.17995  1.000 13.68551 ? 672 TYR   B C    1 
ATOM   3102 O O    . TYR   A 1 194 ? 15.42447  11.21256  36.35857  1.000 14.51789 ? 672 TYR   B O    1 
ATOM   3103 C CB   . TYR   A 1 194 ? 14.02714  13.56422  37.93503  1.000 13.11694 ? 672 TYR   B CB   1 
ATOM   3104 C CG   . TYR   A 1 194 ? 12.79876  14.34078  38.33959  1.000 13.27984 ? 672 TYR   B CG   1 
ATOM   3105 C CD1  . TYR   A 1 194 ? 12.68013  15.71622  38.05516  1.000 13.87830 ? 672 TYR   B CD1  1 
ATOM   3106 C CD2  . TYR   A 1 194 ? 11.72316  13.69437  38.96809  1.000 14.64049 ? 672 TYR   B CD2  1 
ATOM   3107 C CE1  . TYR   A 1 194 ? 11.54486  16.40473  38.38392  1.000 16.10331 ? 672 TYR   B CE1  1 
ATOM   3108 C CE2  . TYR   A 1 194 ? 10.58841  14.40650  39.28911  1.000 16.51479 ? 672 TYR   B CE2  1 
ATOM   3109 C CZ   . TYR   A 1 194 ? 10.51608  15.75359  39.01206  1.000 15.55076 ? 672 TYR   B CZ   1 
ATOM   3110 O OH   . TYR   A 1 194 ? 9.37923   16.44460  39.35585  1.000 16.28125 ? 672 TYR   B OH   1 
ATOM   3111 H H    . TYR   A 1 194 ? 13.02677  11.46504  36.38673  1.000 15.74149 ? 672 TYR   B H    1 
ATOM   3112 H HA   . TYR   A 1 194 ? 13.98615  13.95158  35.92113  1.000 14.10385 ? 672 TYR   B HA   1 
ATOM   3113 H HB2  . TYR   A 1 194 ? 14.06585  12.76561  38.48423  1.000 15.69434 ? 672 TYR   B HB2  1 
ATOM   3114 H HB3  . TYR   A 1 194 ? 14.80046  14.12364  38.10803  1.000 15.69434 ? 672 TYR   B HB3  1 
ATOM   3115 H HD1  . TYR   A 1 194 ? 13.38260  16.16121  37.63872  1.000 16.60797 ? 672 TYR   B HD1  1 
ATOM   3116 H HD2  . TYR   A 1 194 ? 11.77633  12.78752  39.16735  1.000 17.52260 ? 672 TYR   B HD2  1 
ATOM   3117 H HE1  . TYR   A 1 194 ? 11.47176  17.30965  38.18221  1.000 19.27799 ? 672 TYR   B HE1  1 
ATOM   3118 H HE2  . TYR   A 1 194 ? 9.86977   13.97670  39.69374  1.000 19.77176 ? 672 TYR   B HE2  1 
ATOM   3119 H HH   . TYR   A 1 194 ? 9.38379   17.20303  38.99478  1.000 19.49152 ? 672 TYR   B HH   1 
ATOM   3120 N N    . LEU   A 1 195 ? 16.34957  13.18390  35.72572  1.000 12.88504 ? 673 LEU   B N    1 
ATOM   3121 C CA   . LEU   A 1 195 ? 17.71382  12.69850  35.61519  1.000 12.23648 ? 673 LEU   B CA   1 
ATOM   3122 C C    . LEU   A 1 195 ? 18.57673  13.40232  36.64561  1.000 13.49805 ? 673 LEU   B C    1 
ATOM   3123 O O    . LEU   A 1 195 ? 18.65284  14.63964  36.63704  1.000 13.14526 ? 673 LEU   B O    1 
ATOM   3124 C CB   . LEU   A 1 195 ? 18.23001  12.92811  34.20276  1.000 13.38092 ? 673 LEU   B CB   1 
ATOM   3125 C CG   . LEU   A 1 195 ? 19.68459  12.48796  33.98591  1.000 13.92164 ? 673 LEU   B CG   1 
ATOM   3126 C CD1  . LEU   A 1 195 ? 19.87630  11.01792  34.28834  1.000 13.00593 ? 673 LEU   B CD1  1 
ATOM   3127 C CD2  . LEU   A 1 195 ? 20.13319  12.86592  32.59270  1.000 15.84713 ? 673 LEU   B CD2  1 
ATOM   3128 H H    . LEU   A 1 195 ? 16.25509  14.00054  35.47317  1.000 15.41607 ? 673 LEU   B H    1 
ATOM   3129 H HA   . LEU   A 1 195 ? 17.75216  11.74877  35.80871  1.000 14.63779 ? 673 LEU   B HA   1 
ATOM   3130 H HB2  . LEU   A 1 195 ? 17.67490  12.42698  33.58501  1.000 16.01112 ? 673 LEU   B HB2  1 
ATOM   3131 H HB3  . LEU   A 1 195 ? 18.17574  13.87589  34.00360  1.000 16.01112 ? 673 LEU   B HB3  1 
ATOM   3132 H HG   . LEU   A 1 195 ? 20.26099  12.95442  34.61127  1.000 16.65998 ? 673 LEU   B HG   1 
ATOM   3133 H HD11 . LEU   A 1 195 ? 20.76177  10.74862  33.99794  1.000 15.56113 ? 673 LEU   B HD11 1 
ATOM   3134 H HD12 . LEU   A 1 195 ? 19.78455  10.87747  35.24372  1.000 15.56113 ? 673 LEU   B HD12 1 
ATOM   3135 H HD13 . LEU   A 1 195 ? 19.20263  10.50718  33.81272  1.000 15.56113 ? 673 LEU   B HD13 1 
ATOM   3136 H HD21 . LEU   A 1 195 ? 21.05136  12.57905  32.46787  1.000 18.97057 ? 673 LEU   B HD21 1 
ATOM   3137 H HD22 . LEU   A 1 195 ? 19.55869  12.42702  31.94600  1.000 18.97057 ? 673 LEU   B HD22 1 
ATOM   3138 H HD23 . LEU   A 1 195 ? 20.07068  13.82855  32.49107  1.000 18.97057 ? 673 LEU   B HD23 1 
ATOM   3139 N N    . ILE   A 1 196 ? 19.18761  12.62326  37.54298  1.000 13.03026 ? 674 ILE   B N    1 
ATOM   3140 C CA   . ILE   A 1 196 ? 20.12396  13.13943  38.52811  1.000 12.87539 ? 674 ILE   B CA   1 
ATOM   3141 C C    . ILE   A 1 196 ? 21.53102  12.88752  37.99529  1.000 13.80197 ? 674 ILE   B C    1 
ATOM   3142 O O    . ILE   A 1 196 ? 21.91659  11.73251  37.73654  1.000 14.33783 ? 674 ILE   B O    1 
ATOM   3143 C CB   . ILE   A 1 196 ? 19.94951  12.48149  39.90753  1.000 13.11669 ? 674 ILE   B CB   1 
ATOM   3144 C CG1  . ILE   A 1 196 ? 18.54270  12.62461  40.42488  1.000 12.25415 ? 674 ILE   B CG1  1 
ATOM   3145 C CG2  . ILE   A 1 196 ? 20.99425  13.05516  40.89529  1.000 14.74785 ? 674 ILE   B CG2  1 
ATOM   3146 C CD1  . ILE   A 1 196 ? 18.26721  11.95833  41.74200  1.000 14.04359 ? 674 ILE   B CD1  1 
ATOM   3147 H H    . ILE   A 1 196 ? 19.06863  11.77323  37.59685  1.000 15.59033 ? 674 ILE   B H    1 
ATOM   3148 H HA   . ILE   A 1 196 ? 19.97595  14.09252  38.63112  1.000 15.40448 ? 674 ILE   B HA   1 
ATOM   3149 H HB   . ILE   A 1 196 ? 20.10474  11.52860  39.81374  1.000 15.69404 ? 674 ILE   B HB   1 
ATOM   3150 H HG12 . ILE   A 1 196 ? 18.35247  13.56948  40.53413  1.000 14.65899 ? 674 ILE   B HG12 1 
ATOM   3151 H HG13 . ILE   A 1 196 ? 17.93721  12.23745  39.77343  1.000 14.65899 ? 674 ILE   B HG13 1 
ATOM   3152 H HG21 . ILE   A 1 196 ? 20.83687  12.67869  41.77529  1.000 17.65143 ? 674 ILE   B HG21 1 
ATOM   3153 H HG22 . ILE   A 1 196 ? 21.88310  12.81762  40.58803  1.000 17.65143 ? 674 ILE   B HG22 1 
ATOM   3154 H HG23 . ILE   A 1 196 ? 20.90217  14.02025  40.92708  1.000 17.65143 ? 674 ILE   B HG23 1 
ATOM   3155 H HD11 . ILE   A 1 196 ? 17.30836  11.92578  41.88500  1.000 16.80633 ? 674 ILE   B HD11 1 
ATOM   3156 H HD12 . ILE   A 1 196 ? 18.62949  11.05873  41.72272  1.000 16.80633 ? 674 ILE   B HD12 1 
ATOM   3157 H HD13 . ILE   A 1 196 ? 18.68995  12.47007  42.44932  1.000 16.80633 ? 674 ILE   B HD13 1 
ATOM   3158 N N    . THR   A 1 197 ? 22.30828  13.95914  37.86779  1.000 13.25179 ? 675 THR   B N    1 
ATOM   3159 C CA   . THR   A 1 197 ? 23.73725  13.87252  37.57491  1.000 14.44291 ? 675 THR   B CA   1 
ATOM   3160 C C    . THR   A 1 197 ? 24.48107  14.14893  38.87365  1.000 14.09569 ? 675 THR   B C    1 
ATOM   3161 O O    . THR   A 1 197 ? 24.18776  15.15679  39.54455  1.000 14.38926 ? 675 THR   B O    1 
ATOM   3162 C CB   . THR   A 1 197 ? 24.14813  14.87306  36.51613  1.000 14.06472 ? 675 THR   B CB   1 
ATOM   3163 O OG1  . THR   A 1 197 ? 23.38118  14.66225  35.33851  1.000 14.77129 ? 675 THR   B OG1  1 
ATOM   3164 C CG2  . THR   A 1 197 ? 25.61848  14.71947  36.14439  1.000 14.49308 ? 675 THR   B CG2  1 
ATOM   3165 H H    . THR   A 1 197 ? 22.02467  14.76702  37.94840  1.000 15.85617 ? 675 THR   B H    1 
ATOM   3166 H HA   . THR   A 1 197 ? 23.96311  12.99103  37.23896  1.000 17.28551 ? 675 THR   B HA   1 
ATOM   3167 H HB   . THR   A 1 197 ? 24.00439  15.76557  36.86780  1.000 16.83167 ? 675 THR   B HB   1 
ATOM   3168 H HG1  . THR   A 1 197 ? 22.56528  14.77589  35.50284  1.000 17.67957 ? 675 THR   B HG1  1 
ATOM   3169 H HG21 . THR   A 1 197 ? 25.83403  15.29909  35.39708  1.000 17.34571 ? 675 THR   B HG21 1 
ATOM   3170 H HG22 . THR   A 1 197 ? 26.17832  14.95825  36.89968  1.000 17.34571 ? 675 THR   B HG22 1 
ATOM   3171 H HG23 . THR   A 1 197 ? 25.80308  13.80078  35.89371  1.000 17.34571 ? 675 THR   B HG23 1 
ATOM   3172 N N    . PHE   A 1 198 ? 25.39898  13.24703  39.24248  1.000 12.52372 ? 676 PHE   B N    1 
ATOM   3173 C CA   . PHE   A 1 198 ? 26.03621  13.35177  40.55316  1.000 15.06635 ? 676 PHE   B CA   1 
ATOM   3174 C C    . PHE   A 1 198 ? 27.47019  12.83366  40.47226  1.000 15.46194 ? 676 PHE   B C    1 
ATOM   3175 O O    . PHE   A 1 198 ? 27.87623  12.18440  39.49517  1.000 15.30473 ? 676 PHE   B O    1 
ATOM   3176 C CB   . PHE   A 1 198 ? 25.25672  12.64377  41.66729  1.000 16.01220 ? 676 PHE   B CB   1 
ATOM   3177 C CG   . PHE   A 1 198 ? 25.10530  11.15283  41.47565  1.000 15.32375 ? 676 PHE   B CG   1 
ATOM   3178 C CD1  . PHE   A 1 198 ? 24.22333  10.65495  40.51018  1.000 15.01088 ? 676 PHE   B CD1  1 
ATOM   3179 C CD2  . PHE   A 1 198 ? 25.75891  10.26121  42.29753  1.000 15.54228 ? 676 PHE   B CD2  1 
ATOM   3180 C CE1  . PHE   A 1 198 ? 24.04976  9.32458   40.33414  1.000 14.28591 ? 676 PHE   B CE1  1 
ATOM   3181 C CE2  . PHE   A 1 198 ? 25.56792  8.88876   42.14854  1.000 17.27537 ? 676 PHE   B CE2  1 
ATOM   3182 C CZ   . PHE   A 1 198 ? 24.73351  8.40113   41.17385  1.000 15.43753 ? 676 PHE   B CZ   1 
ATOM   3183 H H    . PHE   A 1 198 ? 25.66041  12.58391  38.76130  1.000 14.98247 ? 676 PHE   B H    1 
ATOM   3184 H HA   . PHE   A 1 198 ? 26.06713  14.29394  40.78177  1.000 18.03363 ? 676 PHE   B HA   1 
ATOM   3185 H HB2  . PHE   A 1 198 ? 25.72074  12.78550  42.50724  1.000 19.16865 ? 676 PHE   B HB2  1 
ATOM   3186 H HB3  . PHE   A 1 198 ? 24.36603  13.02533  41.71183  1.000 19.16865 ? 676 PHE   B HB3  1 
ATOM   3187 H HD1  . PHE   A 1 198 ? 23.74657  11.25069  39.97850  1.000 17.96708 ? 676 PHE   B HD1  1 
ATOM   3188 H HD2  . PHE   A 1 198 ? 26.33256  10.57784  42.95751  1.000 18.60475 ? 676 PHE   B HD2  1 
ATOM   3189 H HE1  . PHE   A 1 198 ? 23.48391  9.01383   39.66471  1.000 17.09711 ? 676 PHE   B HE1  1 
ATOM   3190 H HE2  . PHE   A 1 198 ? 26.00984  8.29792   42.71468  1.000 20.68446 ? 676 PHE   B HE2  1 
ATOM   3191 H HZ   . PHE   A 1 198 ? 24.61721  7.48495   41.06429  1.000 18.47904 ? 676 PHE   B HZ   1 
ATOM   3192 N N    . THR   A 1 199 ? 28.24315  13.17377  41.51022  1.000 16.86593 ? 677 THR   B N    1 
ATOM   3193 C CA   . THR   A 1 199 ? 29.64818  12.82849  41.56077  1.000 16.69182 ? 677 THR   B CA   1 
ATOM   3194 C C    . THR   A 1 199 ? 29.98901  12.40389  42.97255  1.000 20.38028 ? 677 THR   B C    1 
ATOM   3195 O O    . THR   A 1 199 ? 29.22503  12.61627  43.90810  1.000 19.10550 ? 677 THR   B O    1 
ATOM   3196 C CB   . THR   A 1 199 ? 30.57307  13.97147  41.15076  1.000 19.76722 ? 677 THR   B CB   1 
ATOM   3197 O OG1  . THR   A 1 199 ? 30.58296  14.92652  42.21175  1.000 19.53340 ? 677 THR   B OG1  1 
ATOM   3198 C CG2  . THR   A 1 199 ? 30.11397  14.63393  39.86109  1.000 18.66294 ? 677 THR   B CG2  1 
ATOM   3199 H H    . THR   A 1 199 ? 27.96474  13.60840  42.19810  1.000 20.19313 ? 677 THR   B H    1 
ATOM   3200 H HA   . THR   A 1 199 ? 29.79128  12.09527  40.94206  1.000 19.98420 ? 677 THR   B HA   1 
ATOM   3201 H HB   . THR   A 1 199 ? 31.46688  13.63317  40.98474  1.000 23.67468 ? 677 THR   B HB   1 
ATOM   3202 H HG1  . THR   A 1 199 ? 31.09016  15.56714  42.01692  1.000 23.39409 ? 677 THR   B HG1  1 
ATOM   3203 H HG21 . THR   A 1 199 ? 30.76831  15.28986  39.57386  1.000 22.34955 ? 677 THR   B HG21 1 
ATOM   3204 H HG22 . THR   A 1 199 ? 30.00993  13.96710  39.16437  1.000 22.34955 ? 677 THR   B HG22 1 
ATOM   3205 H HG23 . THR   A 1 199 ? 29.26321  15.07838  40.00102  1.000 22.34955 ? 677 THR   B HG23 1 
ATOM   3206 N N    . ALA   A 1 200 ? 31.16442  11.77598  43.12936  1.000 21.81147 ? 678 ALA   B N    1 
ATOM   3207 C CA   . ALA   A 1 200 ? 31.66332  11.45319  44.47529  1.000 25.31561 ? 678 ALA   B CA   1 
ATOM   3208 C C    . ALA   A 1 200 ? 32.19839  12.72013  45.14234  1.000 32.74315 ? 678 ALA   B C    1 
ATOM   3209 O O    . ALA   A 1 200 ? 32.33405  13.75884  44.48759  1.000 28.06786 ? 678 ALA   B O    1 
ATOM   3210 C CB   . ALA   A 1 200 ? 32.74722  10.37859  44.41316  1.000 28.63523 ? 678 ALA   B CB   1 
ATOM   3211 O OXT  . ALA   A 1 200 ? 32.47702  12.75501  46.34211  1.000 35.24130 ? 678 ALA   B OXT  1 
ATOM   3212 H H    . ALA   A 1 200 ? 31.68014  11.53181  42.48592  1.000 26.12778 ? 678 ALA   B H    1 
ATOM   3213 H HA   . ALA   A 1 200 ? 30.93899  11.09508  45.01196  1.000 30.33274 ? 678 ALA   B HA   1 
ATOM   3214 H HB1  . ALA   A 1 200 ? 33.05524  10.18833  45.31306  1.000 34.31629 ? 678 ALA   B HB1  1 
ATOM   3215 H HB2  . ALA   A 1 200 ? 32.37438  9.57665   44.01469  1.000 34.31629 ? 678 ALA   B HB2  1 
ATOM   3216 H HB3  . ALA   A 1 200 ? 33.48427  10.70432  43.87320  1.000 34.31629 ? 678 ALA   B HB3  1 
ATOM   3217 N N    . ASN   B 1 3   ? -13.71436 6.33862   20.58551  1.000 49.84747 ? 481 ASN   A N    1 
ATOM   3218 C CA   . ASN   B 1 3   ? -12.58998 5.46789   20.87923  1.000 44.20308 ? 481 ASN   A CA   1 
ATOM   3219 C C    . ASN   B 1 3   ? -12.66607 4.17458   20.06137  1.000 49.37494 ? 481 ASN   A C    1 
ATOM   3220 O O    . ASN   B 1 3   ? -11.92875 3.99785   19.07600  1.000 41.04890 ? 481 ASN   A O    1 
ATOM   3221 C CB   . ASN   B 1 3   ? -12.54268 5.12954   22.37702  1.000 34.59917 ? 481 ASN   A CB   1 
ATOM   3222 H HA   . ASN   B 1 3   ? -11.76985 5.93007   20.64540  1.000 52.99771 ? 481 ASN   A HA   1 
ATOM   3223 N N    . LEU   B 1 4   ? -13.56521 3.27579   20.46734  1.000 46.76783 ? 482 LEU   A N    1 
ATOM   3224 C CA   . LEU   B 1 4   ? -13.62422 1.94132   19.85951  1.000 46.33662 ? 482 LEU   A CA   1 
ATOM   3225 C C    . LEU   B 1 4   ? -14.25421 2.00131   18.46518  1.000 46.78052 ? 482 LEU   A C    1 
ATOM   3226 O O    . LEU   B 1 4   ? -15.18984 2.77448   18.23516  1.000 48.72474 ? 482 LEU   A O    1 
ATOM   3227 C CB   . LEU   B 1 4   ? -14.41284 0.99531   20.75018  1.000 41.30025 ? 482 LEU   A CB   1 
ATOM   3228 C CG   . LEU   B 1 4   ? -13.90720 0.85985   22.19120  1.000 40.63517 ? 482 LEU   A CG   1 
ATOM   3229 C CD1  . LEU   B 1 4   ? -14.68083 -0.22689  22.94121  1.000 39.01650 ? 482 LEU   A CD1  1 
ATOM   3230 C CD2  . LEU   B 1 4   ? -12.40660 0.57379   22.23760  1.000 37.26802 ? 482 LEU   A CD2  1 
ATOM   3231 H H    . LEU   B 1 4   ? -14.14709 3.41005   21.08620  1.000 56.07541 ? 482 LEU   A H    1 
ATOM   3232 H HA   . LEU   B 1 4   ? -12.72478 1.59263   19.75789  1.000 55.55796 ? 482 LEU   A HA   1 
ATOM   3233 H HB2  . LEU   B 1 4   ? -15.32828 1.31295   20.79462  1.000 49.51431 ? 482 LEU   A HB2  1 
ATOM   3234 H HB3  . LEU   B 1 4   ? -14.38736 0.11140   20.35151  1.000 49.51431 ? 482 LEU   A HB3  1 
ATOM   3235 H HG   . LEU   B 1 4   ? -14.05718 1.70627   22.64061  1.000 48.71621 ? 482 LEU   A HG   1 
ATOM   3236 H HD11 . LEU   B 1 4   ? -14.34111 -0.28781  23.84773  1.000 46.77382 ? 482 LEU   A HD11 1 
ATOM   3237 H HD12 . LEU   B 1 4   ? -15.62179 0.00823   22.95569  1.000 46.77382 ? 482 LEU   A HD12 1 
ATOM   3238 H HD13 . LEU   B 1 4   ? -14.55851 -1.07387  22.48451  1.000 46.77382 ? 482 LEU   A HD13 1 
ATOM   3239 H HD21 . LEU   B 1 4   ? -12.15868 0.33419   23.14426  1.000 44.67564 ? 482 LEU   A HD21 1 
ATOM   3240 H HD22 . LEU   B 1 4   ? -12.20612 -0.15950  21.63511  1.000 44.67564 ? 482 LEU   A HD22 1 
ATOM   3241 H HD23 . LEU   B 1 4   ? -11.92479 1.36935   21.96220  1.000 44.67564 ? 482 LEU   A HD23 1 
ATOM   3242 N N    . PRO   B 1 5   ? -13.76097 1.19659   17.52223  1.000 40.35760 ? 483 PRO   A N    1 
ATOM   3243 C CA   . PRO   B 1 5   ? -14.23975 1.29738   16.14099  1.000 40.01569 ? 483 PRO   A CA   1 
ATOM   3244 C C    . PRO   B 1 5   ? -15.72642 1.02333   16.01835  1.000 43.71798 ? 483 PRO   A C    1 
ATOM   3245 O O    . PRO   B 1 5   ? -16.33334 0.34576   16.84573  1.000 39.26276 ? 483 PRO   A O    1 
ATOM   3246 C CB   . PRO   B 1 5   ? -13.43502 0.22856   15.39651  1.000 36.85438 ? 483 PRO   A CB   1 
ATOM   3247 C CG   . PRO   B 1 5   ? -12.21743 0.02688   16.23314  1.000 36.03432 ? 483 PRO   A CG   1 
ATOM   3248 C CD   . PRO   B 1 5   ? -12.65849 0.22981   17.65595  1.000 35.25454 ? 483 PRO   A CD   1 
ATOM   3249 H HA   . PRO   B 1 5   ? -14.03998 2.17930   15.79000  1.000 47.97284 ? 483 PRO   A HA   1 
ATOM   3250 H HB2  . PRO   B 1 5   ? -13.95177 -0.58960  15.32962  1.000 44.17927 ? 483 PRO   A HB2  1 
ATOM   3251 H HB3  . PRO   B 1 5   ? -13.20078 0.54639   14.51050  1.000 44.17927 ? 483 PRO   A HB3  1 
ATOM   3252 H HG2  . PRO   B 1 5   ? -11.87696 -0.87217  16.10393  1.000 43.19520 ? 483 PRO   A HG2  1 
ATOM   3253 H HG3  . PRO   B 1 5   ? -11.54035 0.67655   15.98739  1.000 43.19520 ? 483 PRO   A HG3  1 
ATOM   3254 H HD2  . PRO   B 1 5   ? -12.97176 -0.60213  18.04406  1.000 42.25947 ? 483 PRO   A HD2  1 
ATOM   3255 H HD3  . PRO   B 1 5   ? -11.93890 0.59634   18.19330  1.000 42.25947 ? 483 PRO   A HD3  1 
ATOM   3256 N N    . GLU   B 1 6   ? -16.30218 1.54905   14.93277  1.000 50.64035 ? 484 GLU   A N    1 
ATOM   3257 C CA   . GLU   B 1 6   ? -17.74091 1.43873   14.72277  1.000 49.20464 ? 484 GLU   A CA   1 
ATOM   3258 C C    . GLU   B 1 6   ? -18.13931 0.01963   14.34120  1.000 46.09620 ? 484 GLU   A C    1 
ATOM   3259 O O    . GLU   B 1 6   ? -19.18987 -0.46766  14.77392  1.000 46.74686 ? 484 GLU   A O    1 
ATOM   3260 C CB   . GLU   B 1 6   ? -18.18907 2.42458   13.64085  1.000 46.22781 ? 484 GLU   A CB   1 
ATOM   3261 H H    . GLU   B 1 6   ? -15.88372 1.97000   14.31044  1.000 60.72243 ? 484 GLU   A H    1 
ATOM   3262 H HA   . GLU   B 1 6   ? -18.19310 1.66700   15.55000  1.000 58.99958 ? 484 GLU   A HA   1 
ATOM   3263 N N    . HIS   B 1 7   ? -17.31292 -0.65928  13.53999  1.000 41.33159 ? 485 HIS   A N    1 
ATOM   3264 C CA   . HIS   B 1 7   ? -17.64519 -2.00171  13.07560  1.000 36.06780 ? 485 HIS   A CA   1 
ATOM   3265 C C    . HIS   B 1 7   ? -17.53258 -3.06761  14.16667  1.000 35.43193 ? 485 HIS   A C    1 
ATOM   3266 O O    . HIS   B 1 7   ? -17.95475 -4.21984  13.94817  1.000 29.21582 ? 485 HIS   A O    1 
ATOM   3267 C CB   . HIS   B 1 7   ? -16.74816 -2.38409  11.91713  1.000 37.68002 ? 485 HIS   A CB   1 
ATOM   3268 C CG   . HIS   B 1 7   ? -15.32142 -2.62137  12.30625  1.000 44.21841 ? 485 HIS   A CG   1 
ATOM   3269 N ND1  . HIS   B 1 7   ? -14.45349 -1.59788  12.62910  1.000 38.37010 ? 485 HIS   A ND1  1 
ATOM   3270 C CD2  . HIS   B 1 7   ? -14.61332 -3.76890  12.42938  1.000 41.26999 ? 485 HIS   A CD2  1 
ATOM   3271 C CE1  . HIS   B 1 7   ? -13.26850 -2.10764  12.91520  1.000 44.84233 ? 485 HIS   A CE1  1 
ATOM   3272 N NE2  . HIS   B 1 7   ? -13.33855 -3.42147  12.80249  1.000 43.56060 ? 485 HIS   A NE2  1 
ATOM   3273 H H    . HIS   B 1 7   ? -16.55781 -0.36316  13.25411  1.000 49.55193 ? 485 HIS   A H    1 
ATOM   3274 H HA   . HIS   B 1 7   ? -18.56457 -1.99144  12.76653  1.000 43.23538 ? 485 HIS   A HA   1 
ATOM   3275 H HB2  . HIS   B 1 7   ? -17.08557 -3.20170  11.51893  1.000 45.17004 ? 485 HIS   A HB2  1 
ATOM   3276 H HB3  . HIS   B 1 7   ? -16.76080 -1.66714  11.26389  1.000 45.17004 ? 485 HIS   A HB3  1 
ATOM   3277 H HD2  . HIS   B 1 7   ? -14.93112 -4.63135  12.28768  1.000 49.47801 ? 485 HIS   A HD2  1 
ATOM   3278 H HE1  . HIS   B 1 7   ? -12.51224 -1.62266  13.15554  1.000 53.76481 ? 485 HIS   A HE1  1 
ATOM   3279 H HE2  . HIS   B 1 7   ? -12.69094 -3.97028  12.94038  1.000 52.22673 ? 485 HIS   A HE2  1 
ATOM   3280 N N    . TRP   B 1 8   ? -16.94149 -2.73791  15.30744  1.000 30.56501 ? 486 TRP   A N    1 
ATOM   3281 C CA   . TRP   B 1 8   ? -17.03960 -3.61828  16.45157  1.000 27.85407 ? 486 TRP   A CA   1 
ATOM   3282 C C    . TRP   B 1 8   ? -18.49762 -3.74523  16.87515  1.000 27.58836 ? 486 TRP   A C    1 
ATOM   3283 O O    . TRP   B 1 8   ? -19.32461 -2.88770  16.59049  1.000 28.06917 ? 486 TRP   A O    1 
ATOM   3284 C CB   . TRP   B 1 8   ? -16.21535 -3.09733  17.62893  1.000 27.95458 ? 486 TRP   A CB   1 
ATOM   3285 C CG   . TRP   B 1 8   ? -14.72903 -3.22300  17.45394  1.000 26.57649 ? 486 TRP   A CG   1 
ATOM   3286 C CD1  . TRP   B 1 8   ? -14.05506 -3.46605  16.29837  1.000 28.04333 ? 486 TRP   A CD1  1 
ATOM   3287 C CD2  . TRP   B 1 8   ? -13.74017 -3.10340  18.48420  1.000 22.52437 ? 486 TRP   A CD2  1 
ATOM   3288 N NE1  . TRP   B 1 8   ? -12.69936 -3.53062  16.54392  1.000 22.61658 ? 486 TRP   A NE1  1 
ATOM   3289 C CE2  . TRP   B 1 8   ? -12.48336 -3.30942  17.88055  1.000 22.58026 ? 486 TRP   A CE2  1 
ATOM   3290 C CE3  . TRP   B 1 8   ? -13.79978 -2.86638  19.85706  1.000 25.72605 ? 486 TRP   A CE3  1 
ATOM   3291 C CZ2  . TRP   B 1 8   ? -11.28410 -3.23073  18.60223  1.000 20.98925 ? 486 TRP   A CZ2  1 
ATOM   3292 C CZ3  . TRP   B 1 8   ? -12.60000 -2.80628  20.58198  1.000 24.89699 ? 486 TRP   A CZ3  1 
ATOM   3293 C CH2  . TRP   B 1 8   ? -11.37517 -2.99096  19.95061  1.000 20.70724 ? 486 TRP   A CH2  1 
ATOM   3294 H H    . TRP   B 1 8   ? -16.48576 -2.02054  15.43893  1.000 36.63202 ? 486 TRP   A H    1 
ATOM   3295 H HA   . TRP   B 1 8   ? -16.69126 -4.49124  16.21176  1.000 33.37890 ? 486 TRP   A HA   1 
ATOM   3296 H HB2  . TRP   B 1 8   ? -16.41670 -2.15684  17.75483  1.000 33.49951 ? 486 TRP   A HB2  1 
ATOM   3297 H HB3  . TRP   B 1 8   ? -16.45992 -3.59813  18.42283  1.000 33.49951 ? 486 TRP   A HB3  1 
ATOM   3298 H HD1  . TRP   B 1 8   ? -14.45073 -3.57320  15.46359  1.000 33.60601 ? 486 TRP   A HD1  1 
ATOM   3299 H HE1  . TRP   B 1 8   ? -12.09033 -3.68411  15.95645  1.000 27.09391 ? 486 TRP   A HE1  1 
ATOM   3300 H HE3  . TRP   B 1 8   ? -14.61810 -2.75049  20.28346  1.000 30.82527 ? 486 TRP   A HE3  1 
ATOM   3301 H HZ2  . TRP   B 1 8   ? -10.46010 -3.33670  18.18426  1.000 25.14111 ? 486 TRP   A HZ2  1 
ATOM   3302 H HZ3  . TRP   B 1 8   ? -12.62437 -2.64074  21.49680  1.000 29.83041 ? 486 TRP   A HZ3  1 
ATOM   3303 H HH2  . TRP   B 1 8   ? -10.59559 -2.95090  20.45613  1.000 24.80271 ? 486 TRP   A HH2  1 
ATOM   3304 N N    . THR   B 1 9   ? -18.79519 -4.81944  17.58621  1.000 23.62930 ? 487 THR   A N    1 
ATOM   3305 C CA   . THR   B 1 9   ? -20.12481 -5.04365  18.13061  1.000 25.56494 ? 487 THR   A CA   1 
ATOM   3306 C C    . THR   B 1 9   ? -20.08887 -4.87179  19.63855  1.000 28.03682 ? 487 THR   A C    1 
ATOM   3307 O O    . THR   B 1 9   ? -19.02125 -4.85942  20.25556  1.000 22.56007 ? 487 THR   A O    1 
ATOM   3308 C CB   . THR   B 1 9   ? -20.65311 -6.43470  17.74886  1.000 30.87102 ? 487 THR   A CB   1 
ATOM   3309 O OG1  . THR   B 1 9   ? -19.67157 -7.44922  17.96751  1.000 26.97230 ? 487 THR   A OG1  1 
ATOM   3310 C CG2  . THR   B 1 9   ? -21.05645 -6.44625  16.24995  1.000 32.19937 ? 487 THR   A CG2  1 
ATOM   3311 H H    . THR   B 1 9   ? -18.23406 -5.44453  17.77059  1.000 28.30917 ? 487 THR   A H    1 
ATOM   3312 H HA   . THR   B 1 9   ? -20.74663 -4.39365  17.76765  1.000 30.63194 ? 487 THR   A HA   1 
ATOM   3313 H HB   . THR   B 1 9   ? -21.42348 -6.63430  18.30347  1.000 36.99924 ? 487 THR   A HB   1 
ATOM   3314 H HG1  . THR   B 1 9   ? -19.97874 -8.19881  17.74535  1.000 32.32077 ? 487 THR   A HG1  1 
ATOM   3315 H HG21 . THR   B 1 9   ? -21.23712 -7.35473  15.96200  1.000 38.59325 ? 487 THR   A HG21 1 
ATOM   3316 H HG22 . THR   B 1 9   ? -21.85329 -5.90942  16.11667  1.000 38.59325 ? 487 THR   A HG22 1 
ATOM   3317 H HG23 . THR   B 1 9   ? -20.33756 -6.08199  15.71013  1.000 38.59325 ? 487 THR   A HG23 1 
ATOM   3318 N N    . ASP   B 1 10  ? -21.27044 -4.70801  20.22039  1.000 24.94227 ? 488 ASP   A N    1 
ATOM   3319 C CA   . ASP   B 1 10  ? -21.36856 -4.38418  21.63867  1.000 25.99114 ? 488 ASP   A CA   1 
ATOM   3320 C C    . ASP   B 1 10  ? -20.73154 -5.46323  22.50298  1.000 25.24074 ? 488 ASP   A C    1 
ATOM   3321 O O    . ASP   B 1 10  ? -20.83611 -6.65541  22.21377  1.000 26.16569 ? 488 ASP   A O    1 
ATOM   3322 C CB   . ASP   B 1 10  ? -22.83580 -4.21168  22.03693  1.000 27.15402 ? 488 ASP   A CB   1 
ATOM   3323 C CG   . ASP   B 1 10  ? -22.98718 -3.71930  23.47033  1.000 29.21637 ? 488 ASP   A CG   1 
ATOM   3324 O OD1  . ASP   B 1 10  ? -22.73608 -2.53210  23.70334  1.000 28.74167 ? 488 ASP   A OD1  1 
ATOM   3325 O OD2  . ASP   B 1 10  ? -23.33324 -4.52831  24.34616  1.000 32.35149 ? 488 ASP   A OD2  1 
ATOM   3326 H H    . ASP   B 1 10  ? -22.02787 -4.77832  19.81920  1.000 29.88474 ? 488 ASP   A H    1 
ATOM   3327 H HA   . ASP   B 1 10  ? -20.89549 -3.55272  21.79924  1.000 31.14338 ? 488 ASP   A HA   1 
ATOM   3328 H HB2  . ASP   B 1 10  ? -23.25134 -3.56218  21.44840  1.000 32.53884 ? 488 ASP   A HB2  1 
ATOM   3329 H HB3  . ASP   B 1 10  ? -23.28900 -5.06593  21.96097  1.000 32.53884 ? 488 ASP   A HB3  1 
ATOM   3330 N N    . MET   B 1 11  ? -20.11506 -5.03832  23.60303  1.000 28.60854 ? 489 MET   A N    1 
ATOM   3331 C CA   . MET   B 1 11  ? -19.41278 -5.95025  24.49260  1.000 32.67560 ? 489 MET   A CA   1 
ATOM   3332 C C    . MET   B 1 11  ? -19.97639 -5.95473  25.90401  1.000 32.40461 ? 489 MET   A C    1 
ATOM   3333 O O    . MET   B 1 11  ? -19.32128 -6.44860  26.82514  1.000 29.85052 ? 489 MET   A O    1 
ATOM   3334 C CB   . MET   B 1 11  ? -17.92118 -5.59137  24.51915  1.000 33.75519 ? 489 MET   A CB   1 
ATOM   3335 C CG   . MET   B 1 11  ? -17.20121 -6.00258  23.28066  1.000 31.99729 ? 489 MET   A CG   1 
ATOM   3336 S SD   . MET   B 1 11  ? -15.43202 -5.83203  23.51477  1.000 27.78629 ? 489 MET   A SD   1 
ATOM   3337 C CE   . MET   B 1 11  ? -15.19639 -4.10370  23.26768  1.000 21.59093 ? 489 MET   A CE   1 
ATOM   3338 H H    . MET   B 1 11  ? -20.09097 -4.21663  23.85572  1.000 34.28426 ? 489 MET   A H    1 
ATOM   3339 H HA   . MET   B 1 11  ? -19.51202 -6.84924  24.14208  1.000 39.16474 ? 489 MET   A HA   1 
ATOM   3340 H HB2  . MET   B 1 11  ? -17.83034 -4.63021  24.61308  1.000 40.46024 ? 489 MET   A HB2  1 
ATOM   3341 H HB3  . MET   B 1 11  ? -17.50306 -6.03919  25.27117  1.000 40.46024 ? 489 MET   A HB3  1 
ATOM   3342 H HG2  . MET   B 1 11  ? -17.40089 -6.93026  23.07955  1.000 38.35077 ? 489 MET   A HG2  1 
ATOM   3343 H HG3  . MET   B 1 11  ? -17.47365 -5.43678  22.54138  1.000 38.35077 ? 489 MET   A HG3  1 
ATOM   3344 H HE1  . MET   B 1 11  ? -14.25555 -3.89444  23.37694  1.000 25.86313 ? 489 MET   A HE1  1 
ATOM   3345 H HE2  . MET   B 1 11  ? -15.48520 -3.87054  22.37151  1.000 25.86313 ? 489 MET   A HE2  1 
ATOM   3346 H HE3  . MET   B 1 11  ? -15.72170 -3.61668  23.92171  1.000 25.86313 ? 489 MET   A HE3  1 
ATOM   3347 N N    . ASN   B 1 12  ? -21.18940 -5.43780  26.09369  1.000 32.74108 ? 490 ASN   A N    1 
ATOM   3348 C CA   . ASN   B 1 12  ? -21.83903 -5.44667  27.39597  1.000 34.64074 ? 490 ASN   A CA   1 
ATOM   3349 C C    . ASN   B 1 12  ? -20.91498 -4.85396  28.45155  1.000 33.27882 ? 490 ASN   A C    1 
ATOM   3350 O O    . ASN   B 1 12  ? -20.78459 -5.37501  29.55726  1.000 31.63402 ? 490 ASN   A O    1 
ATOM   3351 C CB   . ASN   B 1 12  ? -22.28993 -6.86143  27.78491  1.000 32.34669 ? 490 ASN   A CB   1 
ATOM   3352 C CG   . ASN   B 1 12  ? -23.33520 -7.41082  26.85041  1.000 37.74658 ? 490 ASN   A CG   1 
ATOM   3353 O OD1  . ASN   B 1 12  ? -24.53373 -7.14081  27.01158  1.000 47.71274 ? 490 ASN   A OD1  1 
ATOM   3354 N ND2  . ASN   B 1 12  ? -22.90586 -8.18387  25.86970  1.000 38.03506 ? 490 ASN   A ND2  1 
ATOM   3355 H H    . ASN   B 1 12  ? -21.66005 -5.07217  25.47368  1.000 39.24331 ? 490 ASN   A H    1 
ATOM   3356 H HA   . ASN   B 1 12  ? -22.63490 -4.89404  27.35041  1.000 41.52290 ? 490 ASN   A HA   1 
ATOM   3357 H HB2  . ASN   B 1 12  ? -21.52371 -7.45582  27.76230  1.000 38.77004 ? 490 ASN   A HB2  1 
ATOM   3358 H HB3  . ASN   B 1 12  ? -22.66666 -6.83966  28.67850  1.000 38.77004 ? 490 ASN   A HB3  1 
ATOM   3359 H HD21 . ASN   B 1 12  ? -23.46615 -8.52070  25.31093  1.000 45.59609 ? 490 ASN   A HD21 1 
ATOM   3360 H HD22 . ASN   B 1 12  ? -22.06595 -8.35049  25.78976  1.000 45.59609 ? 490 ASN   A HD22 1 
ATOM   3361 N N    . HIS   B 1 13  ? -20.27693 -3.74055  28.09988  1.000 31.46856 ? 491 HIS   A N    1 
ATOM   3362 C CA   . HIS   B 1 13  ? -19.41843 -2.96893  28.99433  1.000 35.03566 ? 491 HIS   A CA   1 
ATOM   3363 C C    . HIS   B 1 13  ? -18.13837 -3.70739  29.35152  1.000 36.12871 ? 491 HIS   A C    1 
ATOM   3364 O O    . HIS   B 1 13  ? -17.44639 -3.30207  30.29603  1.000 42.06371 ? 491 HIS   A O    1 
ATOM   3365 C CB   . HIS   B 1 13  ? -20.14630 -2.57947  30.29233  1.000 38.72225 ? 491 HIS   A CB   1 
ATOM   3366 C CG   . HIS   B 1 13  ? -21.36800 -1.75339  30.07453  1.000 40.35717 ? 491 HIS   A CG   1 
ATOM   3367 N ND1  . HIS   B 1 13  ? -21.35957 -0.37768  30.16334  1.000 43.74546 ? 491 HIS   A ND1  1 
ATOM   3368 C CD2  . HIS   B 1 13  ? -22.63790 -2.10373  29.75352  1.000 41.44966 ? 491 HIS   A CD2  1 
ATOM   3369 C CE1  . HIS   B 1 13  ? -22.57579 0.08465   29.92099  1.000 47.24372 ? 491 HIS   A CE1  1 
ATOM   3370 N NE2  . HIS   B 1 13  ? -23.37056 -0.94173  29.66947  1.000 42.50924 ? 491 HIS   A NE2  1 
ATOM   3371 H H    . HIS   B 1 13  ? -20.32960 -3.39878  27.31246  1.000 37.71629 ? 491 HIS   A H    1 
ATOM   3372 H HA   . HIS   B 1 13  ? -19.17160 -2.15307  28.53134  1.000 41.99681 ? 491 HIS   A HA   1 
ATOM   3373 H HB2  . HIS   B 1 13  ? -20.41546 -3.38930  30.75345  1.000 46.42072 ? 491 HIS   A HB2  1 
ATOM   3374 H HB3  . HIS   B 1 13  ? -19.53858 -2.06739  30.84853  1.000 46.42072 ? 491 HIS   A HB3  1 
ATOM   3375 H HD2  . HIS   B 1 13  ? -22.95447 -2.96731  29.61593  1.000 49.69361 ? 491 HIS   A HD2  1 
ATOM   3376 H HE1  . HIS   B 1 13  ? -22.82854 0.97963   29.92663  1.000 56.64648 ? 491 HIS   A HE1  1 
ATOM   3377 H HE2  . HIS   B 1 13  ? -24.20873 -0.89137  29.48364  1.000 50.96510 ? 491 HIS   A HE2  1 
ATOM   3378 N N    . GLN   B 1 14  ? -17.79848 -4.77158  28.62937  1.000 32.37620 ? 492 GLN   A N    1 
ATOM   3379 C CA   . GLN   B 1 14  ? -16.53015 -5.45749  28.82586  1.000 32.81427 ? 492 GLN   A CA   1 
ATOM   3380 C C    . GLN   B 1 14  ? -15.46731 -4.90165  27.87578  1.000 29.86135 ? 492 GLN   A C    1 
ATOM   3381 O O    . GLN   B 1 14  ? -15.76033 -4.15217  26.94699  1.000 26.97714 ? 492 GLN   A O    1 
ATOM   3382 C CB   . GLN   B 1 14  ? -16.67573 -6.95681  28.61811  1.000 30.78272 ? 492 GLN   A CB   1 
ATOM   3383 C CG   . GLN   B 1 14  ? -17.80242 -7.54073  29.47734  1.000 35.73028 ? 492 GLN   A CG   1 
ATOM   3384 C CD   . GLN   B 1 14  ? -17.49207 -8.91590  30.02981  1.000 33.97287 ? 492 GLN   A CD   1 
ATOM   3385 O OE1  . GLN   B 1 14  ? -16.49630 -9.53887  29.67497  1.000 29.97724 ? 492 GLN   A OE1  1 
ATOM   3386 N NE2  . GLN   B 1 14  ? -18.35667 -9.39297  30.92037  1.000 33.32253 ? 492 GLN   A NE2  1 
ATOM   3387 H H    . GLN   B 1 14  ? -18.29118 -5.11673  28.01478  1.000 38.80546 ? 492 GLN   A H    1 
ATOM   3388 H HA   . GLN   B 1 14  ? -16.24244 -5.30947  29.74031  1.000 39.33114 ? 492 GLN   A HA   1 
ATOM   3389 H HB2  . GLN   B 1 14  ? -16.88067 -7.13213  27.68636  1.000 36.89328 ? 492 GLN   A HB2  1 
ATOM   3390 H HB3  . GLN   B 1 14  ? -15.84628 -7.39570  28.86363  1.000 36.89328 ? 492 GLN   A HB3  1 
ATOM   3391 H HG2  . GLN   B 1 14  ? -17.96203 -6.94845  30.22875  1.000 42.83035 ? 492 GLN   A HG2  1 
ATOM   3392 H HG3  . GLN   B 1 14  ? -18.60385 -7.61280  28.93565  1.000 42.83035 ? 492 GLN   A HG3  1 
ATOM   3393 H HE21 . GLN   B 1 14  ? -19.04120 -8.92503  31.14852  1.000 39.94105 ? 492 GLN   A HE21 1 
ATOM   3394 H HE22 . GLN   B 1 14  ? -18.23132 -10.16944 31.26818  1.000 39.94105 ? 492 GLN   A HE22 1 
ATOM   3395 N N    . LEU   B 1 15  ? -14.22495 -5.30289  28.11735  1.000 24.83680 ? 493 LEU   A N    1 
ATOM   3396 C CA   . LEU   B 1 15  ? -13.08668 -4.70531  27.42169  1.000 24.97966 ? 493 LEU   A CA   1 
ATOM   3397 C C    . LEU   B 1 15  ? -12.39142 -5.64171  26.44709  1.000 26.84038 ? 493 LEU   A C    1 
ATOM   3398 O O    . LEU   B 1 15  ? -11.51195 -5.18095  25.69431  1.000 22.37270 ? 493 LEU   A O    1 
ATOM   3399 C CB   . LEU   B 1 15  ? -12.05075 -4.20438  28.44471  1.000 25.94333 ? 493 LEU   A CB   1 
ATOM   3400 C CG   . LEU   B 1 15  ? -12.53908 -3.13005  29.40941  1.000 31.89916 ? 493 LEU   A CG   1 
ATOM   3401 C CD1  . LEU   B 1 15  ? -11.66943 -3.08506  30.66085  1.000 31.07843 ? 493 LEU   A CD1  1 
ATOM   3402 C CD2  . LEU   B 1 15  ? -12.57178 -1.78642  28.72597  1.000 33.37475 ? 493 LEU   A CD2  1 
ATOM   3403 H H    . LEU   B 1 15  ? -14.01351 -5.91898  28.67890  1.000 29.75818 ? 493 LEU   A H    1 
ATOM   3404 H HA   . LEU   B 1 15  ? -13.41170 -3.94670  26.91203  1.000 29.92961 ? 493 LEU   A HA   1 
ATOM   3405 H HB2  . LEU   B 1 15  ? -11.76092 -4.96082  28.97828  1.000 31.08601 ? 493 LEU   A HB2  1 
ATOM   3406 H HB3  . LEU   B 1 15  ? -11.29800 -3.83403  27.95777  1.000 31.08601 ? 493 LEU   A HB3  1 
ATOM   3407 H HG   . LEU   B 1 15  ? -13.44194 -3.34596  29.69071  1.000 38.23300 ? 493 LEU   A HG   1 
ATOM   3408 H HD11 . LEU   B 1 15  ? -11.99186 -2.38042  31.24431  1.000 37.24814 ? 493 LEU   A HD11 1 
ATOM   3409 H HD12 . LEU   B 1 15  ? -11.72400 -3.94082  31.11427  1.000 37.24814 ? 493 LEU   A HD12 1 
ATOM   3410 H HD13 . LEU   B 1 15  ? -10.75203 -2.90597  30.40162  1.000 37.24814 ? 493 LEU   A HD13 1 
ATOM   3411 H HD21 . LEU   B 1 15  ? -12.88430 -1.11889  29.35655  1.000 40.00372 ? 493 LEU   A HD21 1 
ATOM   3412 H HD22 . LEU   B 1 15  ? -11.67713 -1.56355  28.42459  1.000 40.00372 ? 493 LEU   A HD22 1 
ATOM   3413 H HD23 . LEU   B 1 15  ? -13.17447 -1.83259  27.96733  1.000 40.00372 ? 493 LEU   A HD23 1 
ATOM   3414 N N    . PHE   B 1 16  ? -12.73749 -6.93355  26.44798  1.000 25.33555 ? 494 PHE   A N    1 
ATOM   3415 C CA   . PHE   B 1 16  ? -12.14726 -7.89947  25.53155  1.000 23.72165 ? 494 PHE   A CA   1 
ATOM   3416 C C    . PHE   B 1 16  ? -13.21112 -8.87911  25.06560  1.000 22.99877 ? 494 PHE   A C    1 
ATOM   3417 O O    . PHE   B 1 16  ? -13.94799 -9.43571  25.88171  1.000 21.70953 ? 494 PHE   A O    1 
ATOM   3418 C CB   . PHE   B 1 16  ? -10.99306 -8.67931  26.19405  1.000 22.30645 ? 494 PHE   A CB   1 
ATOM   3419 C CG   . PHE   B 1 16  ? -10.50146 -9.83209  25.39237  1.000 24.31012 ? 494 PHE   A CG   1 
ATOM   3420 C CD1  . PHE   B 1 16  ? -9.68324  -9.64217  24.31547  1.000 20.25231 ? 494 PHE   A CD1  1 
ATOM   3421 C CD2  . PHE   B 1 16  ? -10.87931 -11.11789 25.71780  1.000 27.89642 ? 494 PHE   A CD2  1 
ATOM   3422 C CE1  . PHE   B 1 16  ? -9.23096  -10.70514 23.56552  1.000 21.04773 ? 494 PHE   A CE1  1 
ATOM   3423 C CE2  . PHE   B 1 16  ? -10.43766 -12.20804 24.97677  1.000 26.52378 ? 494 PHE   A CE2  1 
ATOM   3424 C CZ   . PHE   B 1 16  ? -9.59831  -12.00105 23.90563  1.000 25.20376 ? 494 PHE   A CZ   1 
ATOM   3425 H H    . PHE   B 1 16  ? -13.32101 -7.27434  26.97992  1.000 30.35668 ? 494 PHE   A H    1 
ATOM   3426 H HA   . PHE   B 1 16  ? -11.80323 -7.42259  24.76011  1.000 28.42000 ? 494 PHE   A HA   1 
ATOM   3427 H HB2  . PHE   B 1 16  ? -10.24677 -8.07459  26.32918  1.000 26.72176 ? 494 PHE   A HB2  1 
ATOM   3428 H HB3  . PHE   B 1 16  ? -11.30006 -9.02329  27.04748  1.000 26.72176 ? 494 PHE   A HB3  1 
ATOM   3429 H HD1  . PHE   B 1 16  ? -9.42661  -8.77873  24.08418  1.000 24.25679 ? 494 PHE   A HD1  1 
ATOM   3430 H HD2  . PHE   B 1 16  ? -11.43991 -11.25827 26.44644  1.000 33.42972 ? 494 PHE   A HD2  1 
ATOM   3431 H HE1  . PHE   B 1 16  ? -8.67976  -10.55542 22.83158  1.000 25.21129 ? 494 PHE   A HE1  1 
ATOM   3432 H HE2  . PHE   B 1 16  ? -10.70678 -13.06912 25.20263  1.000 31.78255 ? 494 PHE   A HE2  1 
ATOM   3433 H HZ   . PHE   B 1 16  ? -9.27967  -12.72298 23.41352  1.000 30.19853 ? 494 PHE   A HZ   1 
ATOM   3434 N N    . CYS   B 1 17  ? -13.26445 -9.11140  23.76050  1.000 20.56308 ? 495 CYS   A N    1 
ATOM   3435 C CA   . CYS   B 1 17  ? -14.17077 -10.10759 23.20560  1.000 22.85792 ? 495 CYS   A CA   1 
ATOM   3436 C C    . CYS   B 1 17  ? -13.57802 -10.58107 21.88427  1.000 21.46976 ? 495 CYS   A C    1 
ATOM   3437 O O    . CYS   B 1 17  ? -13.05146 -9.76592  21.12511  1.000 21.36076 ? 495 CYS   A O    1 
ATOM   3438 C CB   . CYS   B 1 17  ? -15.57205 -9.48462  23.00235  1.000 23.78556 ? 495 CYS   A CB   1 
ATOM   3439 S SG   . CYS   B 1 17  ? -16.86685 -10.72552 22.63434  1.000 39.17448 ? 495 CYS   A SG   1 
ATOM   3440 H H    . CYS   B 1 17  ? -12.78498 -8.70455  23.17384  1.000 24.62971 ? 495 CYS   A H    1 
ATOM   3441 H HA   . CYS   B 1 17  ? -14.26073 -10.87724 23.78908  1.000 27.38352 ? 495 CYS   A HA   1 
ATOM   3442 H HB2  . CYS   B 1 17  ? -15.82822 -9.01719  23.81277  1.000 28.49669 ? 495 CYS   A HB2  1 
ATOM   3443 H HB3  . CYS   B 1 17  ? -15.53426 -8.86301  22.25867  1.000 28.49669 ? 495 CYS   A HB3  1 
ATOM   3444 H HG   . CYS   B 1 17  ? -16.57227 -11.31121 21.62926  1.000 46.96340 ? 495 CYS   A HG   1 
ATOM   3445 N N    . MET   B 1 18  ? -13.67357 -11.87612 21.62713  1.000 20.94093 ? 496 MET   A N    1 
ATOM   3446 C CA   . MET   B 1 18  ? -13.43963 -12.46786 20.31188  1.000 20.07195 ? 496 MET   A CA   1 
ATOM   3447 C C    . MET   B 1 18  ? -14.79377 -12.73306 19.66137  1.000 19.59342 ? 496 MET   A C    1 
ATOM   3448 O O    . MET   B 1 18  ? -15.61642 -13.46255 20.23359  1.000 22.24785 ? 496 MET   A O    1 
ATOM   3449 C CB   . MET   B 1 18  ? -12.66769 -13.78170 20.42764  1.000 20.79625 ? 496 MET   A CB   1 
ATOM   3450 C CG   . MET   B 1 18  ? -11.32950 -13.64162 21.14391  1.000 24.25378 ? 496 MET   A CG   1 
ATOM   3451 S SD   . MET   B 1 18  ? -10.07998 -12.84545 20.10036  1.000 19.54226 ? 496 MET   A SD   1 
ATOM   3452 C CE   . MET   B 1 18  ? -9.77808  -14.09359 18.86555  1.000 18.78358 ? 496 MET   A CE   1 
ATOM   3453 H H    . MET   B 1 18  ? -13.88156 -12.46122 22.22210  1.000 25.08313 ? 496 MET   A H    1 
ATOM   3454 H HA   . MET   B 1 18  ? -12.91692 -11.85153 19.77541  1.000 24.04035 ? 496 MET   A HA   1 
ATOM   3455 H HB2  . MET   B 1 18  ? -13.20560 -14.41738 20.92510  1.000 24.90952 ? 496 MET   A HB2  1 
ATOM   3456 H HB3  . MET   B 1 18  ? -12.49303 -14.12111 19.53590  1.000 24.90952 ? 496 MET   A HB3  1 
ATOM   3457 H HG2  . MET   B 1 18  ? -11.44905 -13.10039 21.93996  1.000 29.05855 ? 496 MET   A HG2  1 
ATOM   3458 H HG3  . MET   B 1 18  ? -11.00441 -14.52249 21.38738  1.000 29.05855 ? 496 MET   A HG3  1 
ATOM   3459 H HE1  . MET   B 1 18  ? -9.03097  -13.81645 18.31245  1.000 22.49431 ? 496 MET   A HE1  1 
ATOM   3460 H HE2  . MET   B 1 18  ? -9.56941  -14.93134 19.30775  1.000 22.49431 ? 496 MET   A HE2  1 
ATOM   3461 H HE3  . MET   B 1 18  ? -10.57331 -14.19676 18.31979  1.000 22.49431 ? 496 MET   A HE3  1 
ATOM   3462 N N    . VAL   B 1 19  ? -15.02929 -12.14445 18.49991  1.000 17.45658 ? 497 VAL   A N    1 
ATOM   3463 C CA   . VAL   B 1 19  ? -16.33007 -12.18007 17.83018  1.000 18.81495 ? 497 VAL   A CA   1 
ATOM   3464 C C    . VAL   B 1 19  ? -16.18007 -12.96962 16.53082  1.000 18.53534 ? 497 VAL   A C    1 
ATOM   3465 O O    . VAL   B 1 19  ? -15.52187 -12.52915 15.58251  1.000 17.97088 ? 497 VAL   A O    1 
ATOM   3466 C CB   . VAL   B 1 19  ? -16.86580 -10.77408 17.55797  1.000 19.10396 ? 497 VAL   A CB   1 
ATOM   3467 C CG1  . VAL   B 1 19  ? -18.27895 -10.84822 16.91875  1.000 23.88205 ? 497 VAL   A CG1  1 
ATOM   3468 C CG2  . VAL   B 1 19  ? -16.89617 -9.94465  18.82805  1.000 20.99103 ? 497 VAL   A CG2  1 
ATOM   3469 H H    . VAL   B 1 19  ? -14.43519 -11.70280 18.06221  1.000 20.90192 ? 497 VAL   A H    1 
ATOM   3470 H HA   . VAL   B 1 19  ? -16.95950 -12.65239 18.39731  1.000 22.53196 ? 497 VAL   A HA   1 
ATOM   3471 H HB   . VAL   B 1 19  ? -16.26922 -10.33296 16.93313  1.000 22.87876 ? 497 VAL   A HB   1 
ATOM   3472 H HG11 . VAL   B 1 19  ? -18.65611 -9.95531  16.88187  1.000 28.61247 ? 497 VAL   A HG11 1 
ATOM   3473 H HG12 . VAL   B 1 19  ? -18.20162 -11.21190 16.02284  1.000 28.61247 ? 497 VAL   A HG12 1 
ATOM   3474 H HG13 . VAL   B 1 19  ? -18.84133 -11.42268 17.46154  1.000 28.61247 ? 497 VAL   A HG13 1 
ATOM   3475 H HG21 . VAL   B 1 19  ? -17.31596 -9.09113  18.63788  1.000 25.14325 ? 497 VAL   A HG21 1 
ATOM   3476 H HG22 . VAL   B 1 19  ? -17.40457 -10.42009 19.50362  1.000 25.14325 ? 497 VAL   A HG22 1 
ATOM   3477 H HG23 . VAL   B 1 19  ? -15.98695 -9.80483  19.13574  1.000 25.14325 ? 497 VAL   A HG23 1 
ATOM   3478 N N    . GLN   B 1 20  ? -16.83175 -14.11911 16.45350  1.000 19.67195 ? 498 GLN   A N    1 
ATOM   3479 C CA   . GLN   B 1 20  ? -16.75432 -14.90556 15.23317  1.000 20.01140 ? 498 GLN   A CA   1 
ATOM   3480 C C    . GLN   B 1 20  ? -17.55064 -14.21431 14.14631  1.000 23.79439 ? 498 GLN   A C    1 
ATOM   3481 O O    . GLN   B 1 20  ? -18.68791 -13.79478 14.37954  1.000 20.84923 ? 498 GLN   A O    1 
ATOM   3482 C CB   . GLN   B 1 20  ? -17.28721 -16.31975 15.49171  1.000 22.64659 ? 498 GLN   A CB   1 
ATOM   3483 C CG   . GLN   B 1 20  ? -17.18623 -17.22940 14.28658  1.000 22.81136 ? 498 GLN   A CG   1 
ATOM   3484 C CD   . GLN   B 1 20  ? -17.48837 -18.67577 14.62944  1.000 27.77671 ? 498 GLN   A CD   1 
ATOM   3485 O OE1  . GLN   B 1 20  ? -17.20030 -19.13557 15.72721  1.000 31.29944 ? 498 GLN   A OE1  1 
ATOM   3486 N NE2  . GLN   B 1 20  ? -18.03554 -19.40071 13.67611  1.000 30.37422 ? 498 GLN   A NE2  1 
ATOM   3487 H H    . GLN   B 1 20  ? -17.31481 -14.45881 17.07869  1.000 23.56036 ? 498 GLN   A H    1 
ATOM   3488 H HA   . GLN   B 1 20  ? -15.83463 -14.98738 14.93588  1.000 23.96769 ? 498 GLN   A HA   1 
ATOM   3489 H HB2  . GLN   B 1 20  ? -16.77497 -16.72082 16.21119  1.000 27.12993 ? 498 GLN   A HB2  1 
ATOM   3490 H HB3  . GLN   B 1 20  ? -18.22228 -16.26106 15.74288  1.000 27.12993 ? 498 GLN   A HB3  1 
ATOM   3491 H HG2  . GLN   B 1 20  ? -17.82316 -16.93907 13.61507  1.000 27.32764 ? 498 GLN   A HG2  1 
ATOM   3492 H HG3  . GLN   B 1 20  ? -16.28519 -17.18567 13.93007  1.000 27.32764 ? 498 GLN   A HG3  1 
ATOM   3493 H HE21 . GLN   B 1 20  ? -18.20207 -19.04807 12.90962  1.000 36.40308 ? 498 GLN   A HE21 1 
ATOM   3494 H HE22 . GLN   B 1 20  ? -18.22640 -20.22684 13.81996  1.000 36.40308 ? 498 GLN   A HE22 1 
ATOM   3495 N N    . LEU   B 1 21  ? -16.94317 -14.05812 12.97652  1.000 19.01899 ? 499 LEU   A N    1 
ATOM   3496 C CA   . LEU   B 1 21  ? -17.60483 -13.38109 11.87068  1.000 21.20894 ? 499 LEU   A CA   1 
ATOM   3497 C C    . LEU   B 1 21  ? -18.59517 -14.30131 11.15901  1.000 20.03501 ? 499 LEU   A C    1 
ATOM   3498 O O    . LEU   B 1 21  ? -18.38746 -15.50406 11.05871  1.000 22.73739 ? 499 LEU   A O    1 
ATOM   3499 C CB   . LEU   B 1 21  ? -16.58628 -12.89078 10.85514  1.000 20.19155 ? 499 LEU   A CB   1 
ATOM   3500 C CG   . LEU   B 1 21  ? -15.60162 -11.81876 11.31450  1.000 19.82981 ? 499 LEU   A CG   1 
ATOM   3501 C CD1  . LEU   B 1 21  ? -14.70149 -11.45753 10.13211  1.000 18.83330 ? 499 LEU   A CD1  1 
ATOM   3502 C CD2  . LEU   B 1 21  ? -16.32143 -10.60658 11.88365  1.000 25.11347 ? 499 LEU   A CD2  1 
ATOM   3503 H H    . LEU   B 1 21  ? -16.14870 -14.33499 12.79830  1.000 22.77680 ? 499 LEU   A H    1 
ATOM   3504 H HA   . LEU   B 1 21  ? -18.09170 -12.62230 12.22859  1.000 25.40474 ? 499 LEU   A HA   1 
ATOM   3505 H HB2  . LEU   B 1 21  ? -16.05946 -13.65372 10.57006  1.000 24.18387 ? 499 LEU   A HB2  1 
ATOM   3506 H HB3  . LEU   B 1 21  ? -17.07206 -12.52249 10.10063  1.000 24.18387 ? 499 LEU   A HB3  1 
ATOM   3507 H HG   . LEU   B 1 21  ? -15.04897 -12.15252 12.03843  1.000 23.74979 ? 499 LEU   A HG   1 
ATOM   3508 H HD11 . LEU   B 1 21  ? -14.06920 -10.77756 10.41274  1.000 22.55397 ? 499 LEU   A HD11 1 
ATOM   3509 H HD12 . LEU   B 1 21  ? -14.22612 -12.25203 9.84282   1.000 22.55397 ? 499 LEU   A HD12 1 
ATOM   3510 H HD13 . LEU   B 1 21  ? -15.25151 -11.11921 9.40829   1.000 22.55397 ? 499 LEU   A HD13 1 
ATOM   3511 H HD21 . LEU   B 1 21  ? -15.67697 -9.89656  12.03008  1.000 30.09017 ? 499 LEU   A HD21 1 
ATOM   3512 H HD22 . LEU   B 1 21  ? -16.99702 -10.31493 11.25166  1.000 30.09017 ? 499 LEU   A HD22 1 
ATOM   3513 H HD23 . LEU   B 1 21  ? -16.73885 -10.85289 12.72389  1.000 30.09017 ? 499 LEU   A HD23 1 
ATOM   3514 N N    . GLU   B 1 22  ? -19.65388 -13.69462 10.64584  1.000 23.79399 ? 500 GLU   A N    1 
ATOM   3515 C CA   . GLU   B 1 22  ? -20.67524 -14.39955 9.88218   1.000 26.95760 ? 500 GLU   A CA   1 
ATOM   3516 C C    . GLU   B 1 22  ? -20.18279 -14.61291 8.45943   1.000 23.60385 ? 500 GLU   A C    1 
ATOM   3517 O O    . GLU   B 1 22  ? -19.95377 -13.62854 7.74099   1.000 25.12690 ? 500 GLU   A O    1 
ATOM   3518 C CB   . GLU   B 1 22  ? -21.97623 -13.58937 9.86478   1.000 31.22973 ? 500 GLU   A CB   1 
ATOM   3519 C CG   . GLU   B 1 22  ? -23.14553 -14.24292 9.13203   1.000 36.90346 ? 500 GLU   A CG   1 
ATOM   3520 C CD   . GLU   B 1 22  ? -23.94499 -15.17732 10.02161  1.000 39.53539 ? 500 GLU   A CD   1 
ATOM   3521 O OE1  . GLU   B 1 22  ? -23.60150 -15.31884 11.22132  1.000 45.03987 ? 500 GLU   A OE1  1 
ATOM   3522 O OE2  . GLU   B 1 22  ? -24.91237 -15.76455 9.52332   1.000 44.35785 ? 500 GLU   A OE2  1 
ATOM   3523 H H    . GLU   B 1 22  ? -19.81052 -12.85286 10.72646  1.000 28.50680 ? 500 GLU   A H    1 
ATOM   3524 H HA   . GLU   B 1 22  ? -20.85399 -15.26287 10.28669  1.000 32.30314 ? 500 GLU   A HA   1 
ATOM   3525 H HB2  . GLU   B 1 22  ? -22.25608 -13.44143 10.78167  1.000 37.42969 ? 500 GLU   A HB2  1 
ATOM   3526 H HB3  . GLU   B 1 22  ? -21.80120 -12.74002 9.43018   1.000 37.42969 ? 500 GLU   A HB3  1 
ATOM   3527 H HG2  . GLU   B 1 22  ? -23.74352 -13.55060 8.80954   1.000 44.23816 ? 500 GLU   A HG2  1 
ATOM   3528 H HG3  . GLU   B 1 22  ? -22.80255 -14.75908 8.38582   1.000 44.23816 ? 500 GLU   A HG3  1 
ATOM   3529 N N    . PRO   B 1 23  ? -20.05793 -15.85037 7.99736   1.000 22.50966 ? 501 PRO   A N    1 
ATOM   3530 C CA   . PRO   B 1 23  ? -19.62222 -16.07097 6.61429   1.000 26.60918 ? 501 PRO   A CA   1 
ATOM   3531 C C    . PRO   B 1 23  ? -20.60636 -15.47800 5.62210   1.000 30.94470 ? 501 PRO   A C    1 
ATOM   3532 O O    . PRO   B 1 23  ? -21.82032 -15.48273 5.84483   1.000 31.14860 ? 501 PRO   A O    1 
ATOM   3533 C CB   . PRO   B 1 23  ? -19.57255 -17.60032 6.49609   1.000 29.19481 ? 501 PRO   A CB   1 
ATOM   3534 C CG   . PRO   B 1 23  ? -19.47139 -18.09059 7.89652   1.000 28.93411 ? 501 PRO   A CG   1 
ATOM   3535 C CD   . PRO   B 1 23  ? -20.21914 -17.12981 8.72969   1.000 28.12696 ? 501 PRO   A CD   1 
ATOM   3536 H HA   . PRO   B 1 23  ? -18.73943 -15.69549 6.47077   1.000 31.88503 ? 501 PRO   A HA   1 
ATOM   3537 H HB2  . PRO   B 1 23  ? -20.38215 -17.92528 6.07202   1.000 34.98778 ? 501 PRO   A HB2  1 
ATOM   3538 H HB3  . PRO   B 1 23  ? -18.79687 -17.86654 5.97807   1.000 34.98778 ? 501 PRO   A HB3  1 
ATOM   3539 H HG2  . PRO   B 1 23  ? -19.86378 -18.97540 7.96008   1.000 34.67495 ? 501 PRO   A HG2  1 
ATOM   3540 H HG3  . PRO   B 1 23  ? -18.53936 -18.12104 8.16351   1.000 34.67495 ? 501 PRO   A HG3  1 
ATOM   3541 H HD2  . PRO   B 1 23  ? -21.15480 -17.37865 8.78902   1.000 33.70637 ? 501 PRO   A HD2  1 
ATOM   3542 H HD3  . PRO   B 1 23  ? -19.83467 -17.07034 9.61826   1.000 33.70637 ? 501 PRO   A HD3  1 
ATOM   3543 N N    . GLY   B 1 24  ? -20.06305 -14.93664 4.52743   1.000 29.66130 ? 502 GLY   A N    1 
ATOM   3544 C CA   . GLY   B 1 24  ? -20.85295 -14.34514 3.47379   1.000 30.41316 ? 502 GLY   A CA   1 
ATOM   3545 C C    . GLY   B 1 24  ? -21.16117 -12.86920 3.64384   1.000 30.22966 ? 502 GLY   A C    1 
ATOM   3546 O O    . GLY   B 1 24  ? -21.59736 -12.21874 2.68045   1.000 29.90524 ? 502 GLY   A O    1 
ATOM   3547 H H    . GLY   B 1 24  ? -19.21652 -14.90480 4.37920   1.000 35.54758 ? 502 GLY   A H    1 
ATOM   3548 H HA2  . GLY   B 1 24  ? -20.37760 -14.45119 2.63492   1.000 36.44981 ? 502 GLY   A HA2  1 
ATOM   3549 H HA3  . GLY   B 1 24  ? -21.69847 -14.81743 3.41956   1.000 36.44981 ? 502 GLY   A HA3  1 
ATOM   3550 N N    . GLN   B 1 25  ? -20.95495 -12.31081 4.82992   1.000 27.47028 ? 503 GLN   A N    1 
ATOM   3551 C CA   . GLN   B 1 25  ? -21.13839 -10.87364 5.00709   1.000 25.18055 ? 503 GLN   A CA   1 
ATOM   3552 C C    . GLN   B 1 25  ? -19.86105 -10.12664 4.65165   1.000 27.41189 ? 503 GLN   A C    1 
ATOM   3553 O O    . GLN   B 1 25  ? -18.77832 -10.71327 4.55657   1.000 27.18000 ? 503 GLN   A O    1 
ATOM   3554 C CB   . GLN   B 1 25  ? -21.59671 -10.57604 6.43140   1.000 27.58941 ? 503 GLN   A CB   1 
ATOM   3555 C CG   . GLN   B 1 25  ? -22.86852 -11.34089 6.77264   1.000 30.27874 ? 503 GLN   A CG   1 
ATOM   3556 C CD   . GLN   B 1 25  ? -23.66107 -10.74918 7.94170   1.000 25.80691 ? 503 GLN   A CD   1 
ATOM   3557 O OE1  . GLN   B 1 25  ? -23.13096 -10.03231 8.77894   1.000 22.14700 ? 503 GLN   A OE1  1 
ATOM   3558 N NE2  . GLN   B 1 25  ? -24.94146 -11.08373 7.99168   1.000 25.16184 ? 503 GLN   A NE2  1 
ATOM   3559 H H    . GLN   B 1 25  ? -20.71206 -12.73521 5.53737   1.000 32.91835 ? 503 GLN   A H    1 
ATOM   3560 H HA   . GLN   B 1 25  ? -21.82931 -10.54482 4.41094   1.000 30.17067 ? 503 GLN   A HA   1 
ATOM   3561 H HB2  . GLN   B 1 25  ? -20.90246 -10.84155 7.05464   1.000 33.06130 ? 503 GLN   A HB2  1 
ATOM   3562 H HB3  . GLN   B 1 25  ? -21.77646 -9.62693  6.51961   1.000 33.06130 ? 503 GLN   A HB3  1 
ATOM   3563 H HG2  . GLN   B 1 25  ? -23.44842 -11.34212 5.99507   1.000 36.28851 ? 503 GLN   A HG2  1 
ATOM   3564 H HG3  . GLN   B 1 25  ? -22.62978 -12.25062 7.00989   1.000 36.28851 ? 503 GLN   A HG3  1 
ATOM   3565 H HE21 . GLN   B 1 25  ? -25.27440 -11.60141 7.39105   1.000 30.14822 ? 503 GLN   A HE21 1 
ATOM   3566 H HE22 . GLN   B 1 25  ? -25.44000 -10.78331 8.62478   1.000 30.14822 ? 503 GLN   A HE22 1 
ATOM   3567 N N    . SER   B 1 26  ? -20.00871 -8.81649  4.44926   1.000 25.75798 ? 504 SER   A N    1 
ATOM   3568 C CA   . SER   B 1 26  ? -18.95662 -8.02872  3.81158   1.000 26.09106 ? 504 SER   A CA   1 
ATOM   3569 C C    . SER   B 1 26  ? -17.61712 -8.15492  4.55254   1.000 24.57815 ? 504 SER   A C    1 
ATOM   3570 O O    . SER   B 1 26  ? -16.56042 -8.32009  3.93177   1.000 25.81275 ? 504 SER   A O    1 
ATOM   3571 C CB   . SER   B 1 26  ? -19.39596 -6.56468  3.71165   1.000 31.57163 ? 504 SER   A CB   1 
ATOM   3572 O OG   . SER   B 1 26  ? -18.38832 -5.75840  3.13185   1.000 43.96800 ? 504 SER   A OG   1 
ATOM   3573 H H    . SER   B 1 26  ? -20.70472 -8.36253  4.67079   1.000 30.86359 ? 504 SER   A H    1 
ATOM   3574 H HA   . SER   B 1 26  ? -18.81836 -8.36713  2.91310   1.000 31.26328 ? 504 SER   A HA   1 
ATOM   3575 H HB2  . SER   B 1 26  ? -20.19286 -6.51395  3.16094   1.000 37.83997 ? 504 SER   A HB2  1 
ATOM   3576 H HB3  . SER   B 1 26  ? -19.58718 -6.23376  4.60318   1.000 37.83997 ? 504 SER   A HB3  1 
ATOM   3577 H HG   . SER   B 1 26  ? -18.64989 -4.96158  3.08430   1.000 52.71561 ? 504 SER   A HG   1 
ATOM   3578 N N    . GLU   B 1 27  ? -17.63929 -8.05257  5.87465   1.000 22.16214 ? 505 GLU   A N    1 
ATOM   3579 C CA   . GLU   B 1 27  ? -16.40120 -8.03490  6.64538   1.000 20.56176 ? 505 GLU   A CA   1 
ATOM   3580 C C    . GLU   B 1 27  ? -15.67804 -9.37352  6.51530   1.000 21.77039 ? 505 GLU   A C    1 
ATOM   3581 O O    . GLU   B 1 27  ? -14.46248 -9.43402  6.27988   1.000 21.10763 ? 505 GLU   A O    1 
ATOM   3582 C CB   . GLU   B 1 27  ? -16.71711 -7.74506  8.11471   1.000 21.36181 ? 505 GLU   A CB   1 
ATOM   3583 C CG   . GLU   B 1 27  ? -15.51590 -7.68068  9.02197   1.000 19.16746 ? 505 GLU   A CG   1 
ATOM   3584 C CD   . GLU   B 1 27  ? -15.87377 -7.19803  10.42954  1.000 25.11451 ? 505 GLU   A CD   1 
ATOM   3585 O OE1  . GLU   B 1 27  ? -17.07868 -7.07097  10.72092  1.000 23.96086 ? 505 GLU   A OE1  1 
ATOM   3586 O OE2  . GLU   B 1 27  ? -14.95405 -6.98944  11.24346  1.000 22.70442 ? 505 GLU   A OE2  1 
ATOM   3587 H H    . GLU   B 1 27  ? -18.35363 -7.99207  6.34970   1.000 26.54858 ? 505 GLU   A H    1 
ATOM   3588 H HA   . GLU   B 1 27  ? -15.82142 -7.33266  6.31129   1.000 24.62813 ? 505 GLU   A HA   1 
ATOM   3589 H HB2  . GLU   B 1 27  ? -17.16888 -6.88837  8.16861   1.000 25.58819 ? 505 GLU   A HB2  1 
ATOM   3590 H HB3  . GLU   B 1 27  ? -17.29683 -8.44742  8.44864   1.000 25.58819 ? 505 GLU   A HB3  1 
ATOM   3591 H HG2  . GLU   B 1 27  ? -15.12661 -8.56599  9.09669   1.000 22.95497 ? 505 GLU   A HG2  1 
ATOM   3592 H HG3  . GLU   B 1 27  ? -14.86778 -7.06380  8.64740   1.000 22.95497 ? 505 GLU   A HG3  1 
ATOM   3593 N N    . TYR   B 1 28  ? -16.41748 -10.46170 6.67999   1.000 20.99368 ? 506 TYR   A N    1 
ATOM   3594 C CA   . TYR   B 1 28  ? -15.83702 -11.79540 6.50574   1.000 20.55246 ? 506 TYR   A CA   1 
ATOM   3595 C C    . TYR   B 1 28  ? -15.26934 -11.95880 5.10408   1.000 22.46300 ? 506 TYR   A C    1 
ATOM   3596 O O    . TYR   B 1 28  ? -14.15769 -12.47317 4.93635   1.000 20.01620 ? 506 TYR   A O    1 
ATOM   3597 C CB   . TYR   B 1 28  ? -16.88641 -12.86029 6.78250   1.000 21.99682 ? 506 TYR   A CB   1 
ATOM   3598 C CG   . TYR   B 1 28  ? -16.45041 -14.28181 6.54521   1.000 21.20338 ? 506 TYR   A CG   1 
ATOM   3599 C CD1  . TYR   B 1 28  ? -16.46256 -14.81984 5.25692   1.000 22.64358 ? 506 TYR   A CD1  1 
ATOM   3600 C CD2  . TYR   B 1 28  ? -16.07942 -15.10746 7.59099   1.000 22.12466 ? 506 TYR   A CD2  1 
ATOM   3601 C CE1  . TYR   B 1 28  ? -16.09053 -16.12894 5.03150   1.000 26.94629 ? 506 TYR   A CE1  1 
ATOM   3602 C CE2  . TYR   B 1 28  ? -15.69738 -16.40511 7.37206   1.000 22.93993 ? 506 TYR   A CE2  1 
ATOM   3603 C CZ   . TYR   B 1 28  ? -15.71755 -16.91741 6.08670   1.000 25.38986 ? 506 TYR   A CZ   1 
ATOM   3604 O OH   . TYR   B 1 28  ? -15.35140 -18.21121 5.86845   1.000 27.83076 ? 506 TYR   A OH   1 
ATOM   3605 H H    . TYR   B 1 28  ? -17.25122 -10.46158 6.89090   1.000 25.14643 ? 506 TYR   A H    1 
ATOM   3606 H HA   . TYR   B 1 28  ? -15.11558 -11.91301 7.14339   1.000 24.61696 ? 506 TYR   A HA   1 
ATOM   3607 H HB2  . TYR   B 1 28  ? -17.15164 -12.79190 7.71302   1.000 26.35019 ? 506 TYR   A HB2  1 
ATOM   3608 H HB3  . TYR   B 1 28  ? -17.64911 -12.69308 6.20698   1.000 26.35019 ? 506 TYR   A HB3  1 
ATOM   3609 H HD1  . TYR   B 1 28  ? -16.72520 -14.28809 4.54056   1.000 27.12631 ? 506 TYR   A HD1  1 
ATOM   3610 H HD2  . TYR   B 1 28  ? -16.08945 -14.77549 8.45967   1.000 26.50360 ? 506 TYR   A HD2  1 
ATOM   3611 H HE1  . TYR   B 1 28  ? -16.09308 -16.47384 4.16782   1.000 32.28957 ? 506 TYR   A HE1  1 
ATOM   3612 H HE2  . TYR   B 1 28  ? -15.42592 -16.93878 8.08367   1.000 27.48193 ? 506 TYR   A HE2  1 
ATOM   3613 H HH   . TYR   B 1 28  ? -15.39859 -18.38879 5.04879   1.000 33.35093 ? 506 TYR   A HH   1 
ATOM   3614 N N    . ASN   B 1 29  ? -16.02129 -11.52617 4.08246   1.000 20.59635 ? 507 ASN   A N    1 
ATOM   3615 C CA   . ASN   B 1 29  ? -15.53807 -11.66474 2.70881   1.000 23.02146 ? 507 ASN   A CA   1 
ATOM   3616 C C    . ASN   B 1 29  ? -14.25421 -10.86299 2.47866   1.000 22.16422 ? 507 ASN   A C    1 
ATOM   3617 O O    . ASN   B 1 29  ? -13.34853 -11.31105 1.76564   1.000 22.87957 ? 507 ASN   A O    1 
ATOM   3618 C CB   . ASN   B 1 29  ? -16.61459 -11.21097 1.72049   1.000 23.20700 ? 507 ASN   A CB   1 
ATOM   3619 C CG   . ASN   B 1 29  ? -17.88892 -12.04677 1.82035   1.000 25.77159 ? 507 ASN   A CG   1 
ATOM   3620 O OD1  . ASN   B 1 29  ? -17.91233 -13.10240 2.44065   1.000 24.05068 ? 507 ASN   A OD1  1 
ATOM   3621 N ND2  . ASN   B 1 29  ? -18.96016 -11.54391 1.21579   1.000 26.76791 ? 507 ASN   A ND2  1 
ATOM   3622 H H    . ASN   B 1 29  ? -16.79498 -11.15845 4.15852   1.000 24.66963 ? 507 ASN   A H    1 
ATOM   3623 H HA   . ASN   B 1 29  ? -15.34633 -12.60222 2.54985   1.000 27.57976 ? 507 ASN   A HA   1 
ATOM   3624 H HB2  . ASN   B 1 29  ? -16.84529 -10.28704 1.90498   1.000 27.80242 ? 507 ASN   A HB2  1 
ATOM   3625 H HB3  . ASN   B 1 29  ? -16.27071 -11.29305 0.81722   1.000 27.80242 ? 507 ASN   A HB3  1 
ATOM   3626 H HD21 . ASN   B 1 29  ? -19.70655 -11.97051 1.23833   1.000 32.07550 ? 507 ASN   A HD21 1 
ATOM   3627 H HD22 . ASN   B 1 29  ? -18.90703 -10.79188 0.80199   1.000 32.07550 ? 507 ASN   A HD22 1 
ATOM   3628 N N    . THR   B 1 30  ? -14.17760 -9.65812  3.04035   1.000 21.15300 ? 508 THR   A N    1 
ATOM   3629 C CA   . THR   B 1 30  ? -12.99409 -8.83482  2.85685   1.000 22.00838 ? 508 THR   A CA   1 
ATOM   3630 C C    . THR   B 1 30  ? -11.75805 -9.50557  3.43627   1.000 22.73941 ? 508 THR   A C    1 
ATOM   3631 O O    . THR   B 1 30  ? -10.71849 -9.58735  2.77353   1.000 21.59827 ? 508 THR   A O    1 
ATOM   3632 C CB   . THR   B 1 30  ? -13.19958 -7.45464  3.46084   1.000 25.74027 ? 508 THR   A CB   1 
ATOM   3633 O OG1  . THR   B 1 30  ? -14.29758 -6.80559  2.81883   1.000 27.21781 ? 508 THR   A OG1  1 
ATOM   3634 C CG2  . THR   B 1 30  ? -11.95022 -6.58811  3.27786   1.000 26.16390 ? 508 THR   A CG2  1 
ATOM   3635 H H    . THR   B 1 30  ? -14.79111 -9.30110  3.52588   1.000 25.33761 ? 508 THR   A H    1 
ATOM   3636 H HA   . THR   B 1 30  ? -12.85075 -8.71670  1.90480   1.000 26.36407 ? 508 THR   A HA   1 
ATOM   3637 H HB   . THR   B 1 30  ? -13.37809 -7.55078  4.40941   1.000 30.84234 ? 508 THR   A HB   1 
ATOM   3638 H HG1  . THR   B 1 30  ? -14.99936 -7.25458  2.92615   1.000 32.61539 ? 508 THR   A HG1  1 
ATOM   3639 H HG21 . THR   B 1 30  ? -12.15829 -5.66079  3.47201   1.000 31.35069 ? 508 THR   A HG21 1 
ATOM   3640 H HG22 . THR   B 1 30  ? -11.24911 -6.88582  3.87845   1.000 31.35069 ? 508 THR   A HG22 1 
ATOM   3641 H HG23 . THR   B 1 30  ? -11.63130 -6.65454  2.36420   1.000 31.35069 ? 508 THR   A HG23 1 
ATOM   3642 N N    . ILE   B 1 31  ? -11.86001 -10.02345 4.65596   1.000 20.16301 ? 509 ILE   A N    1 
ATOM   3643 C CA   . ILE   B 1 31  ? -10.69540 -10.64918 5.28299   1.000 19.34692 ? 509 ILE   A CA   1 
ATOM   3644 C C    . ILE   B 1 31  ? -10.36394 -11.95394 4.58088   1.000 20.63454 ? 509 ILE   A C    1 
ATOM   3645 O O    . ILE   B 1 31  ? -9.19185  -12.26494 4.33686   1.000 20.34070 ? 509 ILE   A O    1 
ATOM   3646 C CB   . ILE   B 1 31  ? -10.94500 -10.86506 6.78527   1.000 18.73811 ? 509 ILE   A CB   1 
ATOM   3647 C CG1  . ILE   B 1 31  ? -11.26893 -9.53647  7.47888   1.000 20.63365 ? 509 ILE   A CG1  1 
ATOM   3648 C CG2  . ILE   B 1 31  ? -9.75083  -11.58744 7.44427   1.000 19.40304 ? 509 ILE   A CG2  1 
ATOM   3649 C CD1  . ILE   B 1 31  ? -10.15599 -8.47848  7.30980   1.000 23.53145 ? 509 ILE   A CD1  1 
ATOM   3650 H H    . ILE   B 1 31  ? -12.57490 -10.02706 5.13398   1.000 24.14963 ? 509 ILE   A H    1 
ATOM   3651 H HA   . ILE   B 1 31  ? -9.93643  -10.05210 5.19152   1.000 23.17032 ? 509 ILE   A HA   1 
ATOM   3652 H HB   . ILE   B 1 31  ? -11.71989 -11.43973 6.88625   1.000 22.43975 ? 509 ILE   A HB   1 
ATOM   3653 H HG12 . ILE   B 1 31  ? -12.08539 -9.17475  7.10013   1.000 24.71439 ? 509 ILE   A HG12 1 
ATOM   3654 H HG13 . ILE   B 1 31  ? -11.38654 -9.69765  8.42813   1.000 24.71439 ? 509 ILE   A HG13 1 
ATOM   3655 H HG21 . ILE   B 1 31  ? -9.84101  -11.53167 8.40846   1.000 23.23766 ? 509 ILE   A HG21 1 
ATOM   3656 H HG22 . ILE   B 1 31  ? -9.75066  -12.51644 7.16525   1.000 23.23766 ? 509 ILE   A HG22 1 
ATOM   3657 H HG23 . ILE   B 1 31  ? -8.92779  -11.15762 7.16363   1.000 23.23766 ? 509 ILE   A HG23 1 
ATOM   3658 H HD11 . ILE   B 1 31  ? -10.37884 -7.69804  7.84097   1.000 28.19176 ? 509 ILE   A HD11 1 
ATOM   3659 H HD12 . ILE   B 1 31  ? -9.31429  -8.85456  7.61145   1.000 28.19176 ? 509 ILE   A HD12 1 
ATOM   3660 H HD13 . ILE   B 1 31  ? -10.09232 -8.23400  6.37327   1.000 28.19176 ? 509 ILE   A HD13 1 
ATOM   3661 N N    . LYS   B 1 32  ? -11.38949 -12.75195 4.26486   1.000 19.69002 ? 510 LYS   A N    1 
ATOM   3662 C CA   . LYS   B 1 32  ? -11.14768 -13.99894 3.54133   1.000 21.74750 ? 510 LYS   A CA   1 
ATOM   3663 C C    . LYS   B 1 32  ? -10.40778 -13.75123 2.23231   1.000 21.71111 ? 510 LYS   A C    1 
ATOM   3664 O O    . LYS   B 1 32  ? -9.48550  -14.50057 1.88238   1.000 21.59720 ? 510 LYS   A O    1 
ATOM   3665 C CB   . LYS   B 1 32  ? -12.48058 -14.70315 3.28659   1.000 21.26072 ? 510 LYS   A CB   1 
ATOM   3666 C CG   . LYS   B 1 32  ? -12.40605 -15.94315 2.39521   1.000 26.92975 ? 510 LYS   A CG   1 
ATOM   3667 C CD   . LYS   B 1 32  ? -13.79127 -16.60490 2.27456   1.000 31.06791 ? 510 LYS   A CD   1 
ATOM   3668 C CE   . LYS   B 1 32  ? -13.97600 -17.32106 0.92209   1.000 38.85482 ? 510 LYS   A CE   1 
ATOM   3669 N NZ   . LYS   B 1 32  ? -14.41389 -18.77065 1.07657   1.000 46.86126 ? 510 LYS   A NZ   1 
ATOM   3670 H H    . LYS   B 1 32  ? -12.21400 -12.59679 4.45382   1.000 23.58204 ? 510 LYS   A H    1 
ATOM   3671 H HA   . LYS   B 1 32  ? -10.59159 -14.57952 4.08409   1.000 26.05102 ? 510 LYS   A HA   1 
ATOM   3672 H HB2  . LYS   B 1 32  ? -12.84685 -14.98217 4.14035   1.000 25.46688 ? 510 LYS   A HB2  1 
ATOM   3673 H HB3  . LYS   B 1 32  ? -13.08144 -14.07407 2.85748   1.000 25.46688 ? 510 LYS   A HB3  1 
ATOM   3674 H HG2  . LYS   B 1 32  ? -12.10695 -15.68846 1.50832   1.000 32.26971 ? 510 LYS   A HG2  1 
ATOM   3675 H HG3  . LYS   B 1 32  ? -11.78968 -16.58474 2.78167   1.000 32.26971 ? 510 LYS   A HG3  1 
ATOM   3676 H HD2  . LYS   B 1 32  ? -13.89365 -17.26175 2.98094   1.000 37.23550 ? 510 LYS   A HD2  1 
ATOM   3677 H HD3  . LYS   B 1 32  ? -14.47789 -15.92418 2.35247   1.000 37.23550 ? 510 LYS   A HD3  1 
ATOM   3678 H HE2  . LYS   B 1 32  ? -14.65501 -16.85626 0.40847   1.000 46.57980 ? 510 LYS   A HE2  1 
ATOM   3679 H HE3  . LYS   B 1 32  ? -13.13310 -17.31240 0.44214   1.000 46.57980 ? 510 LYS   A HE3  1 
ATOM   3680 H HZ1  . LYS   B 1 32  ? -13.80185 -19.22634 1.53468   1.000 56.18753 ? 510 LYS   A HZ1  1 
ATOM   3681 H HZ2  . LYS   B 1 32  ? -15.18902 -18.80971 1.51216   1.000 56.18753 ? 510 LYS   A HZ2  1 
ATOM   3682 H HZ3  . LYS   B 1 32  ? -14.51348 -19.14556 0.27556   1.000 56.18753 ? 510 LYS   A HZ3  1 
ATOM   3683 N N    A ASP   B 1 33  ? -10.80202 -12.71266 1.48977   0.426 22.22177 ? 511 ASP   A N    1 
ATOM   3684 N N    B ASP   B 1 33  ? -10.81900 -12.72710 1.48286   0.574 22.19097 ? 511 ASP   A N    1 
ATOM   3685 C CA   A ASP   B 1 33  ? -10.15970 -12.42794 0.20702   0.426 22.88459 ? 511 ASP   A CA   1 
ATOM   3686 C CA   B ASP   B 1 33  ? -10.16593 -12.41169 0.21295   0.574 22.88480 ? 511 ASP   A CA   1 
ATOM   3687 C C    A ASP   B 1 33  ? -8.67728  -12.09661 0.37817   0.426 22.75071 ? 511 ASP   A C    1 
ATOM   3688 C C    B ASP   B 1 33  ? -8.67888  -12.12265 0.40077   0.574 22.74203 ? 511 ASP   A C    1 
ATOM   3689 O O    A ASP   B 1 33  ? -7.84976  -12.47481 -0.45843  0.426 22.25686 ? 511 ASP   A O    1 
ATOM   3690 O O    B ASP   B 1 33  ? -7.84881  -12.56726 -0.39692  0.574 22.29042 ? 511 ASP   A O    1 
ATOM   3691 C CB   A ASP   B 1 33  ? -10.87047 -11.27194 -0.50200  0.426 24.52745 ? 511 ASP   A CB   1 
ATOM   3692 C CB   B ASP   B 1 33  ? -10.86029 -11.21551 -0.44342  0.574 24.55778 ? 511 ASP   A CB   1 
ATOM   3693 C CG   A ASP   B 1 33  ? -12.26384 -11.63854 -0.98085  0.426 25.69388 ? 511 ASP   A CG   1 
ATOM   3694 C CG   B ASP   B 1 33  ? -10.09266 -10.66169 -1.61860  0.574 24.95746 ? 511 ASP   A CG   1 
ATOM   3695 O OD1  A ASP   B 1 33  ? -12.63734 -12.82134 -0.88691  0.426 27.41092 ? 511 ASP   A OD1  1 
ATOM   3696 O OD1  B ASP   B 1 33  ? -10.06498 -11.33162 -2.66160  0.574 24.96138 ? 511 ASP   A OD1  1 
ATOM   3697 O OD2  A ASP   B 1 33  ? -12.98221 -10.72629 -1.45419  0.426 26.04499 ? 511 ASP   A OD2  1 
ATOM   3698 O OD2  B ASP   B 1 33  ? -9.52408  -9.54379  -1.50131  0.574 25.23719 ? 511 ASP   A OD2  1 
ATOM   3699 H H    A ASP   B 1 33  ? -11.43024 -12.16560 1.70346   0.426 26.62013 ? 511 ASP   A H    1 
ATOM   3700 H H    B ASP   B 1 33  ? -11.46966 -12.20243 1.68526   0.574 26.58317 ? 511 ASP   A H    1 
ATOM   3701 H HA   A ASP   B 1 33  ? -10.23394 -13.22096 -0.34661  0.426 27.41552 ? 511 ASP   A HA   1 
ATOM   3702 H HA   B ASP   B 1 33  ? -10.24761 -13.17826 -0.37578  0.574 27.41577 ? 511 ASP   A HA   1 
ATOM   3703 H HB2  A ASP   B 1 33  ? -10.95211 -10.52681 0.11364   0.426 29.38695 ? 511 ASP   A HB2  1 
ATOM   3704 H HB2  B ASP   B 1 33  ? -11.73385 -11.49313 -0.76080  0.574 29.42335 ? 511 ASP   A HB2  1 
ATOM   3705 H HB3  A ASP   B 1 33  ? -10.34824 -11.00754 -1.27548  0.426 29.38695 ? 511 ASP   A HB3  1 
ATOM   3706 H HB3  B ASP   B 1 33  ? -10.95529 -10.50717 0.21242   0.574 29.42335 ? 511 ASP   A HB3  1 
ATOM   3707 N N    . LYS   B 1 34  ? -8.32102  -11.37302 1.44509   1.000 22.24084 ? 512 LYS   A N    1 
ATOM   3708 C CA   . LYS   B 1 34  ? -6.91369  -11.03693 1.65374   1.000 22.71674 ? 512 LYS   A CA   1 
ATOM   3709 C C    . LYS   B 1 34  ? -6.09212  -12.29109 1.91681   1.000 21.93810 ? 512 LYS   A C    1 
ATOM   3710 O O    . LYS   B 1 34  ? -4.94937  -12.37535 1.48029   1.000 21.69594 ? 512 LYS   A O    1 
ATOM   3711 C CB   . LYS   B 1 34  ? -6.77355  -10.03543 2.78291   1.000 24.29565 ? 512 LYS   A CB   1 
ATOM   3712 C CG   . LYS   B 1 34  ? -7.16687  -8.62896  2.32964   1.000 29.63841 ? 512 LYS   A CG   1 
ATOM   3713 C CD   . LYS   B 1 34  ? -7.31211  -7.62923  3.46549   1.000 39.39839 ? 512 LYS   A CD   1 
ATOM   3714 C CE   . LYS   B 1 34  ? -7.64118  -6.23407  2.88788   1.000 41.80050 ? 512 LYS   A CE   1 
ATOM   3715 N NZ   . LYS   B 1 34  ? -7.98530  -5.22605  3.92538   1.000 53.94413 ? 512 LYS   A NZ   1 
ATOM   3716 H H    A LYS   B 1 34  ? -8.86019  -11.07397 2.04464   0.426 26.64303 ? 512 LYS   A H    1 
ATOM   3717 H H    B LYS   B 1 34  ? -8.86084  -11.05398 2.03365   0.574 26.64303 ? 512 LYS   A H    1 
ATOM   3718 H HA   . LYS   B 1 34  ? -6.55980  -10.61109 0.85729   1.000 27.21410 ? 512 LYS   A HA   1 
ATOM   3719 H HB2  . LYS   B 1 34  ? -7.35340  -10.29462 3.51605   1.000 29.10879 ? 512 LYS   A HB2  1 
ATOM   3720 H HB3  . LYS   B 1 34  ? -5.85078  -10.01456 3.08118   1.000 29.10879 ? 512 LYS   A HB3  1 
ATOM   3721 H HG2  . LYS   B 1 34  ? -6.48391  -8.29322  1.72818   1.000 35.52011 ? 512 LYS   A HG2  1 
ATOM   3722 H HG3  . LYS   B 1 34  ? -8.01951  -8.67706  1.86966   1.000 35.52011 ? 512 LYS   A HG3  1 
ATOM   3723 H HD2  . LYS   B 1 34  ? -8.03340  -7.90254  4.05367   1.000 47.23208 ? 512 LYS   A HD2  1 
ATOM   3724 H HD3  . LYS   B 1 34  ? -6.48123  -7.57399  3.96297   1.000 47.23208 ? 512 LYS   A HD3  1 
ATOM   3725 H HE2  . LYS   B 1 34  ? -6.86852  -5.90644  2.40150   1.000 50.11462 ? 512 LYS   A HE2  1 
ATOM   3726 H HE3  . LYS   B 1 34  ? -8.40041  -6.31413  2.28950   1.000 50.11462 ? 512 LYS   A HE3  1 
ATOM   3727 H HZ1  . LYS   B 1 34  ? -8.42177  -4.54466  3.55483   1.000 64.68697 ? 512 LYS   A HZ1  1 
ATOM   3728 H HZ2  . LYS   B 1 34  ? -8.50203  -5.59522  4.54892   1.000 64.68697 ? 512 LYS   A HZ2  1 
ATOM   3729 H HZ3  . LYS   B 1 34  ? -7.24345  -4.91919  4.30956   1.000 64.68697 ? 512 LYS   A HZ3  1 
ATOM   3730 N N    . PHE   B 1 35  ? -6.67771  -13.26651 2.60030   1.000 19.67997 ? 513 PHE   A N    1 
ATOM   3731 C CA   . PHE   B 1 35  ? -6.03360  -14.54788 2.86093   1.000 19.31495 ? 513 PHE   A CA   1 
ATOM   3732 C C    . PHE   B 1 35  ? -5.97330  -15.38134 1.59195   1.000 20.90022 ? 513 PHE   A C    1 
ATOM   3733 O O    . PHE   B 1 35  ? -4.91263  -15.90154 1.23208   1.000 18.75315 ? 513 PHE   A O    1 
ATOM   3734 C CB   . PHE   B 1 35  ? -6.80436  -15.25935 3.97539   1.000 19.24697 ? 513 PHE   A CB   1 
ATOM   3735 C CG   . PHE   B 1 35  ? -6.35531  -16.67073 4.27039   1.000 19.02502 ? 513 PHE   A CG   1 
ATOM   3736 C CD1  . PHE   B 1 35  ? -5.36880  -16.91528 5.20619   1.000 19.17314 ? 513 PHE   A CD1  1 
ATOM   3737 C CD2  . PHE   B 1 35  ? -6.96264  -17.75663 3.66154   1.000 19.45799 ? 513 PHE   A CD2  1 
ATOM   3738 C CE1  . PHE   B 1 35  ? -4.95751  -18.21381 5.50792   1.000 21.48159 ? 513 PHE   A CE1  1 
ATOM   3739 C CE2  . PHE   B 1 35  ? -6.58036  -19.06362 3.95534   1.000 19.70342 ? 513 PHE   A CE2  1 
ATOM   3740 C CZ   . PHE   B 1 35  ? -5.57299  -19.30067 4.87371   1.000 21.48910 ? 513 PHE   A CZ   1 
ATOM   3741 H H    . PHE   B 1 35  ? -7.46868  -13.21196 2.93346   1.000 23.56998 ? 513 PHE   A H    1 
ATOM   3742 H HA   . PHE   B 1 35  ? -5.12024  -14.41830 3.16074   1.000 23.13196 ? 513 PHE   A HA   1 
ATOM   3743 H HB2  . PHE   B 1 35  ? -6.70354  -14.74664 4.79262   1.000 23.05037 ? 513 PHE   A HB2  1 
ATOM   3744 H HB3  . PHE   B 1 35  ? -7.73994  -15.30004 3.72256   1.000 23.05037 ? 513 PHE   A HB3  1 
ATOM   3745 H HD1  . PHE   B 1 35  ? -4.97014  -16.19852 5.64463   1.000 22.96178 ? 513 PHE   A HD1  1 
ATOM   3746 H HD2  . PHE   B 1 35  ? -7.64103  -17.60983 3.04256   1.000 23.30360 ? 513 PHE   A HD2  1 
ATOM   3747 H HE1  . PHE   B 1 35  ? -4.27832  -18.35710 6.12683   1.000 25.73192 ? 513 PHE   A HE1  1 
ATOM   3748 H HE2  . PHE   B 1 35  ? -7.00248  -19.77718 3.53397   1.000 23.59812 ? 513 PHE   A HE2  1 
ATOM   3749 H HZ   . PHE   B 1 35  ? -5.30779  -20.17073 5.06753   1.000 25.74093 ? 513 PHE   A HZ   1 
ATOM   3750 N N    . THR   B 1 36  ? -7.10843  -15.52675 0.89425   1.000 21.19194 ? 514 THR   A N    1 
ATOM   3751 C CA   . THR   B 1 36  ? -7.15517  -16.45549 -0.23687  1.000 20.41083 ? 514 THR   A CA   1 
ATOM   3752 C C    . THR   B 1 36  ? -6.39514  -15.92287 -1.44838  1.000 21.77592 ? 514 THR   A C    1 
ATOM   3753 O O    . THR   B 1 36  ? -6.15715  -16.68721 -2.38025  1.000 21.99440 ? 514 THR   A O    1 
ATOM   3754 C CB   . THR   B 1 36  ? -8.60490  -16.80127 -0.63739  1.000 19.12696 ? 514 THR   A CB   1 
ATOM   3755 O OG1  . THR   B 1 36  ? -9.35205  -15.64632 -0.94250  1.000 21.91185 ? 514 THR   A OG1  1 
ATOM   3756 C CG2  . THR   B 1 36  ? -9.30200  -17.55875 0.45371   1.000 20.99017 ? 514 THR   A CG2  1 
ATOM   3757 H H    . THR   B 1 36  ? -7.84338  -15.10950 1.05346   1.000 25.38435 ? 514 THR   A H    1 
ATOM   3758 H HA   . THR   B 1 36  ? -6.74723  -17.28875 0.04628   1.000 24.44701 ? 514 THR   A HA   1 
ATOM   3759 H HB   . THR   B 1 36  ? -8.56268  -17.35806 -1.43055  1.000 22.90636 ? 514 THR   A HB   1 
ATOM   3760 H HG1  . THR   B 1 36  ? -9.41342  -15.15607 -0.26318  1.000 26.24824 ? 514 THR   A HG1  1 
ATOM   3761 H HG21 . THR   B 1 36  ? -10.20828 -17.77283 0.18218   1.000 25.14222 ? 514 THR   A HG21 1 
ATOM   3762 H HG22 . THR   B 1 36  ? -8.82652  -18.38316 0.64127   1.000 25.14222 ? 514 THR   A HG22 1 
ATOM   3763 H HG23 . THR   B 1 36  ? -9.33372  -17.02285 1.26161   1.000 25.14222 ? 514 THR   A HG23 1 
ATOM   3764 N N    A ARG   B 1 37  ? -5.99288  -14.64745 -1.44802  0.478 22.81474 ? 515 ARG   A N    1 
ATOM   3765 N N    B ARG   B 1 37  ? -6.01928  -14.63856 -1.46246  0.522 22.78029 ? 515 ARG   A N    1 
ATOM   3766 C CA   A ARG   B 1 37  ? -5.17749  -14.13646 -2.54938  0.478 23.70383 ? 515 ARG   A CA   1 
ATOM   3767 C CA   B ARG   B 1 37  ? -5.16795  -14.13767 -2.54222  0.522 23.71959 ? 515 ARG   A CA   1 
ATOM   3768 C C    A ARG   B 1 37  ? -3.89517  -14.94672 -2.73356  0.478 24.04276 ? 515 ARG   A C    1 
ATOM   3769 C C    B ARG   B 1 37  ? -3.93954  -15.02207 -2.74297  0.522 24.06087 ? 515 ARG   A C    1 
ATOM   3770 O O    A ARG   B 1 37  ? -3.38370  -15.05214 -3.85546  0.478 24.68692 ? 515 ARG   A O    1 
ATOM   3771 O O    B ARG   B 1 37  ? -3.50821  -15.25638 -3.87825  0.522 24.71828 ? 515 ARG   A O    1 
ATOM   3772 C CB   A ARG   B 1 37  ? -4.83363  -12.66361 -2.31557  0.478 24.52123 ? 515 ARG   A CB   1 
ATOM   3773 C CB   B ARG   B 1 37  ? -4.72891  -12.69850 -2.25745  0.522 24.52013 ? 515 ARG   A CB   1 
ATOM   3774 C CG   A ARG   B 1 37  ? -4.55527  -11.88962 -3.59359  0.478 25.02268 ? 515 ARG   A CG   1 
ATOM   3775 C CG   B ARG   B 1 37  ? -5.78663  -11.65608 -2.57890  0.522 25.40323 ? 515 ARG   A CG   1 
ATOM   3776 C CD   A ARG   B 1 37  ? -4.06698  -10.46103 -3.30344  0.478 26.56596 ? 515 ARG   A CD   1 
ATOM   3777 C CD   B ARG   B 1 37  ? -5.37550  -10.28781 -2.06913  0.522 26.05244 ? 515 ARG   A CD   1 
ATOM   3778 N NE   A ARG   B 1 37  ? -2.76529  -10.46963 -2.64778  0.478 27.70318 ? 515 ARG   A NE   1 
ATOM   3779 N NE   B ARG   B 1 37  ? -6.50170  -9.36867  -2.02254  0.522 29.84200 ? 515 ARG   A NE   1 
ATOM   3780 C CZ   A ARG   B 1 37  ? -1.61997  -10.72826 -3.26930  0.478 26.74510 ? 515 ARG   A CZ   1 
ATOM   3781 C CZ   B ARG   B 1 37  ? -6.47581  -8.19254  -1.42308  0.522 29.34995 ? 515 ARG   A CZ   1 
ATOM   3782 N NH1  A ARG   B 1 37  ? -1.58170  -10.99993 -4.56435  0.478 32.93506 ? 515 ARG   A NH1  1 
ATOM   3783 N NH1  B ARG   B 1 37  ? -5.39367  -7.76939  -0.79686  0.522 28.14753 ? 515 ARG   A NH1  1 
ATOM   3784 N NH2  A ARG   B 1 37  ? -0.49128  -10.73426 -2.57195  0.478 28.29806 ? 515 ARG   A NH2  1 
ATOM   3785 N NH2  B ARG   B 1 37  ? -7.56865  -7.42970  -1.44737  0.522 32.19365 ? 515 ARG   A NH2  1 
ATOM   3786 H H    A ARG   B 1 37  ? -6.17487  -14.07167 -0.83568  0.478 27.33170 ? 515 ARG   A H    1 
ATOM   3787 H H    B ARG   B 1 37  ? -6.23878  -14.05232 -0.87276  0.522 27.29037 ? 515 ARG   A H    1 
ATOM   3788 H HA   A ARG   B 1 37  ? -5.69598  -14.20228 -3.36653  0.478 28.39861 ? 515 ARG   A HA   1 
ATOM   3789 H HA   B ARG   B 1 37  ? -5.68810  -14.14048 -3.36096  0.522 28.41752 ? 515 ARG   A HA   1 
ATOM   3790 H HB2  A ARG   B 1 37  ? -5.58029  -12.23645 -1.86731  0.478 29.37949 ? 515 ARG   A HB2  1 
ATOM   3791 H HB2  B ARG   B 1 37  ? -4.51343  -12.61973 -1.31497  0.522 29.37817 ? 515 ARG   A HB2  1 
ATOM   3792 H HB3  A ARG   B 1 37  ? -4.04015  -12.61307 -1.75994  0.478 29.37949 ? 515 ARG   A HB3  1 
ATOM   3793 H HB3  B ARG   B 1 37  ? -3.94589  -12.50011 -2.79450  0.522 29.37817 ? 515 ARG   A HB3  1 
ATOM   3794 H HG2  A ARG   B 1 37  ? -3.86762  -12.34779 -4.10165  0.478 29.98123 ? 515 ARG   A HG2  1 
ATOM   3795 H HG2  B ARG   B 1 37  ? -5.90562  -11.60233 -3.54007  0.522 30.43790 ? 515 ARG   A HG2  1 
ATOM   3796 H HG3  A ARG   B 1 37  ? -5.37040  -11.83121 -4.11613  0.478 29.98123 ? 515 ARG   A HG3  1 
ATOM   3797 H HG3  B ARG   B 1 37  ? -6.62309  -11.90302 -2.15435  0.522 30.43790 ? 515 ARG   A HG3  1 
ATOM   3798 H HD2  A ARG   B 1 37  ? -3.98611  -9.97282  -4.13772  0.478 31.83317 ? 515 ARG   A HD2  1 
ATOM   3799 H HD2  B ARG   B 1 37  ? -5.01701  -10.37494 -1.17203  0.522 31.21695 ? 515 ARG   A HD2  1 
ATOM   3800 H HD3  A ARG   B 1 37  ? -4.70096  -10.01661 -2.71910  0.478 31.83317 ? 515 ARG   A HD3  1 
ATOM   3801 H HD3  B ARG   B 1 37  ? -4.70303  -9.91478  -2.66035  0.522 31.21695 ? 515 ARG   A HD3  1 
ATOM   3802 H HE   A ARG   B 1 37  ? -2.73688  -10.29645 -1.80588  0.478 33.19783 ? 515 ARG   A HE   1 
ATOM   3803 H HE   B ARG   B 1 37  ? -7.23146  -9.60656  -2.41042  0.522 35.76441 ? 515 ARG   A HE   1 
ATOM   3804 H HH11 A ARG   B 1 37  ? -2.30915  -11.01180 -5.02291  0.478 39.47608 ? 515 ARG   A HH11 1 
ATOM   3805 H HH11 B ARG   B 1 37  ? -4.68936  -8.26239  -0.77446  0.522 33.73105 ? 515 ARG   A HH11 1 
ATOM   3806 H HH12 A ARG   B 1 37  ? -0.82938  -11.16455 -4.94713  0.478 39.47608 ? 515 ARG   A HH12 1 
ATOM   3807 H HH12 B ARG   B 1 37  ? -5.39291  -7.00069  -0.41125  0.522 33.73105 ? 515 ARG   A HH12 1 
ATOM   3808 H HH21 A ARG   B 1 37  ? -0.50666  -10.57194 -1.72754  0.478 33.91169 ? 515 ARG   A HH21 1 
ATOM   3809 H HH21 B ARG   B 1 37  ? -8.27693  -7.70580  -1.84950  0.522 38.58639 ? 515 ARG   A HH21 1 
ATOM   3810 H HH22 A ARG   B 1 37  ? 0.25572   -10.90048 -2.96433  0.478 33.91169 ? 515 ARG   A HH22 1 
ATOM   3811 H HH22 B ARG   B 1 37  ? -7.56545  -6.66144  -1.06090  0.522 38.58639 ? 515 ARG   A HH22 1 
ATOM   3812 N N    . THR   B 1 38  ? -3.35765  -15.51763 -1.65247  1.000 22.35742 ? 516 THR   A N    1 
ATOM   3813 C CA   . THR   B 1 38  ? -2.19241  -16.37113 -1.74588  1.000 21.07817 ? 516 THR   A CA   1 
ATOM   3814 C C    . THR   B 1 38  ? -2.36113  -17.71786 -1.05554  1.000 20.65227 ? 516 THR   A C    1 
ATOM   3815 O O    . THR   B 1 38  ? -1.44874  -18.55475 -1.14925  1.000 20.96435 ? 516 THR   A O    1 
ATOM   3816 C CB   . THR   B 1 38  ? -0.93428  -15.68442 -1.16077  1.000 21.92456 ? 516 THR   A CB   1 
ATOM   3817 O OG1  . THR   B 1 38  ? -1.08110  -15.53388 0.26840   1.000 20.17564 ? 516 THR   A OG1  1 
ATOM   3818 C CG2  . THR   B 1 38  ? -0.73697  -14.33180 -1.78406  1.000 22.62530 ? 516 THR   A CG2  1 
ATOM   3819 H H    A THR   B 1 38  ? -3.65806  -15.41987 -0.85260  0.478 26.78292 ? 516 THR   A H    1 
ATOM   3820 H H    B THR   B 1 38  ? -3.62510  -15.36944 -0.84867  0.522 26.78292 ? 516 THR   A H    1 
ATOM   3821 H HA   . THR   B 1 38  ? -2.03486  -16.52565 -2.69045  1.000 25.24782 ? 516 THR   A HA   1 
ATOM   3822 H HB   . THR   B 1 38  ? -0.15319  -16.22794 -1.34890  1.000 26.26349 ? 516 THR   A HB   1 
ATOM   3823 H HG1  . THR   B 1 38  ? -1.74894  -15.05401 0.43964   1.000 24.16478 ? 516 THR   A HG1  1 
ATOM   3824 H HG21 . THR   B 1 38  ? 0.10174   -13.94755 -1.48435  1.000 27.10438 ? 516 THR   A HG21 1 
ATOM   3825 H HG22 . THR   B 1 38  ? -0.71922  -14.41131 -2.75064  1.000 27.10438 ? 516 THR   A HG22 1 
ATOM   3826 H HG23 . THR   B 1 38  ? -1.46272  -13.74043 -1.53013  1.000 27.10438 ? 516 THR   A HG23 1 
ATOM   3827 N N    . CYS   B 1 39  ? -3.48504  -17.95265 -0.35167  1.000 19.37819 ? 517 CYS   A N    1 
ATOM   3828 C CA   . CYS   B 1 39  ? -3.70143  -19.18415 0.37981   1.000 19.15308 ? 517 CYS   A CA   1 
ATOM   3829 C C    . CYS   B 1 39  ? -5.00430  -19.86343 -0.02867  1.000 18.91391 ? 517 CYS   A C    1 
ATOM   3830 O O    . CYS   B 1 39  ? -5.70151  -20.43870 0.81128   1.000 18.63798 ? 517 CYS   A O    1 
ATOM   3831 C CB   . CYS   B 1 39  ? -3.70621  -18.93500 1.87650   1.000 18.75941 ? 517 CYS   A CB   1 
ATOM   3832 S SG   . CYS   B 1 39  ? -2.07514  -18.53404 2.52730   1.000 20.11517 ? 517 CYS   A SG   1 
ATOM   3833 H H    . CYS   B 1 39  ? -4.13755  -17.39570 -0.29128  1.000 23.20784 ? 517 CYS   A H    1 
ATOM   3834 H HA   . CYS   B 1 39  ? -2.97143  -19.78278 0.15699   1.000 22.93771 ? 517 CYS   A HA   1 
ATOM   3835 H HB2  . CYS   B 1 39  ? -4.29724  -18.19055 2.06981   1.000 22.46530 ? 517 CYS   A HB2  1 
ATOM   3836 H HB3  . CYS   B 1 39  ? -4.02067  -19.73406 2.32763   1.000 22.46530 ? 517 CYS   A HB3  1 
ATOM   3837 H HG   . CYS   B 1 39  ? -2.15742  -18.36874 3.71301   1.000 24.09222 ? 517 CYS   A HG   1 
ATOM   3838 N N    . SER   B 1 40  ? -5.31392  -19.84637 -1.32806  1.000 19.62778 ? 518 SER   A N    1 
ATOM   3839 C CA   . SER   B 1 40  ? -6.60463  -20.38709 -1.77183  1.000 20.18447 ? 518 SER   A CA   1 
ATOM   3840 C C    . SER   B 1 40  ? -6.70769  -21.89394 -1.64295  1.000 21.70083 ? 518 SER   A C    1 
ATOM   3841 O O    . SER   B 1 40  ? -7.82004  -22.43550 -1.69306  1.000 23.93169 ? 518 SER   A O    1 
ATOM   3842 C CB   . SER   B 1 40  ? -6.87064  -19.98469 -3.22700  1.000 20.45474 ? 518 SER   A CB   1 
ATOM   3843 O OG   . SER   B 1 40  ? -5.92752  -20.53602 -4.09581  1.000 22.28657 ? 518 SER   A OG   1 
ATOM   3844 H H    . SER   B 1 40  ? -4.81156  -19.53763 -1.95409  1.000 23.50735 ? 518 SER   A H    1 
ATOM   3845 H HA   . SER   B 1 40  ? -7.29298  -20.00051 -1.20823  1.000 24.17537 ? 518 SER   A HA   1 
ATOM   3846 H HB2  . SER   B 1 40  ? -7.75190  -20.29972 -3.48201  1.000 24.49970 ? 518 SER   A HB2  1 
ATOM   3847 H HB3  . SER   B 1 40  ? -6.83113  -19.01795 -3.29588  1.000 24.49970 ? 518 SER   A HB3  1 
ATOM   3848 H HG   . SER   B 1 40  ? -5.15815  -20.26656 -3.89319  1.000 26.69790 ? 518 SER   A HG   1 
ATOM   3849 N N    . SER   B 1 41  ? -5.59212  -22.60463 -1.47479  1.000 19.08679 ? 519 SER   A N    1 
ATOM   3850 C CA   . SER   B 1 41  ? -5.66003  -24.05274 -1.34028  1.000 20.43785 ? 519 SER   A CA   1 
ATOM   3851 C C    . SER   B 1 41  ? -5.95500  -24.49324 0.08477   1.000 20.18170 ? 519 SER   A C    1 
ATOM   3852 O O    . SER   B 1 41  ? -6.05287  -25.68668 0.34716   1.000 21.61403 ? 519 SER   A O    1 
ATOM   3853 C CB   . SER   B 1 41  ? -4.35803  -24.70144 -1.82073  1.000 21.86103 ? 519 SER   A CB   1 
ATOM   3854 O OG   . SER   B 1 41  ? -3.36241  -24.51125 -0.85607  1.000 22.72243 ? 519 SER   A OG   1 
ATOM   3855 H H    . SER   B 1 41  ? -4.79928  -22.27367 -1.43643  1.000 22.85817 ? 519 SER   A H    1 
ATOM   3856 H HA   . SER   B 1 41  ? -6.37262  -24.37932 -1.91164  1.000 24.47943 ? 519 SER   A HA   1 
ATOM   3857 H HB2  . SER   B 1 41  ? -4.50138  -25.65173 -1.95219  1.000 26.18725 ? 519 SER   A HB2  1 
ATOM   3858 H HB3  . SER   B 1 41  ? -4.08155  -24.28922 -2.65412  1.000 26.18725 ? 519 SER   A HB3  1 
ATOM   3859 H HG   . SER   B 1 41  ? -3.23388  -23.69018 -0.73387  1.000 27.22093 ? 519 SER   A HG   1 
ATOM   3860 N N    . TYR   B 1 42  ? -6.05154  -23.55940 1.02874   1.000 21.53597 ? 520 TYR   A N    1 
ATOM   3861 C CA   . TYR   B 1 42  ? -6.31394  -23.90629 2.40955   1.000 21.29115 ? 520 TYR   A CA   1 
ATOM   3862 C C    . TYR   B 1 42  ? -7.83277  -23.90768 2.63406   1.000 25.38601 ? 520 TYR   A C    1 
ATOM   3863 O O    . TYR   B 1 42  ? -8.61778  -23.57057 1.74723   1.000 31.97285 ? 520 TYR   A O    1 
ATOM   3864 C CB   . TYR   B 1 42  ? -5.60468  -22.92077 3.34621   1.000 22.28779 ? 520 TYR   A CB   1 
ATOM   3865 C CG   . TYR   B 1 42  ? -4.08933  -23.04791 3.29563   1.000 20.07500 ? 520 TYR   A CG   1 
ATOM   3866 C CD1  . TYR   B 1 42  ? -3.36736  -22.43252 2.29973   1.000 20.03142 ? 520 TYR   A CD1  1 
ATOM   3867 C CD2  . TYR   B 1 42  ? -3.41210  -23.81968 4.22718   1.000 21.22398 ? 520 TYR   A CD2  1 
ATOM   3868 C CE1  . TYR   B 1 42  ? -1.98516  -22.54128 2.24496   1.000 21.28992 ? 520 TYR   A CE1  1 
ATOM   3869 C CE2  . TYR   B 1 42  ? -2.01915  -23.93502 4.17902   1.000 22.16844 ? 520 TYR   A CE2  1 
ATOM   3870 C CZ   . TYR   B 1 42  ? -1.33713  -23.28922 3.19948   1.000 20.49972 ? 520 TYR   A CZ   1 
ATOM   3871 O OH   . TYR   B 1 42  ? 0.03376   -23.39982 3.12386   1.000 28.86473 ? 520 TYR   A OH   1 
ATOM   3872 H H    . TYR   B 1 42  ? -5.96742  -22.71532 0.88714   1.000 25.79718 ? 520 TYR   A H    1 
ATOM   3873 H HA   . TYR   B 1 42  ? -5.96922  -24.78890 2.61712   1.000 25.50340 ? 520 TYR   A HA   1 
ATOM   3874 H HB2  . TYR   B 1 42  ? -5.83894  -22.01556 3.08813   1.000 26.69936 ? 520 TYR   A HB2  1 
ATOM   3875 H HB3  . TYR   B 1 42  ? -5.89008  -23.09029 4.25764   1.000 26.69936 ? 520 TYR   A HB3  1 
ATOM   3876 H HD1  . TYR   B 1 42  ? -3.81297  -21.93530 1.65235   1.000 23.99171 ? 520 TYR   A HD1  1 
ATOM   3877 H HD2  . TYR   B 1 42  ? -3.88854  -24.26486 4.89029   1.000 25.42279 ? 520 TYR   A HD2  1 
ATOM   3878 H HE1  . TYR   B 1 42  ? -1.50436  -22.11473 1.57281   1.000 25.50192 ? 520 TYR   A HE1  1 
ATOM   3879 H HE2  . TYR   B 1 42  ? -1.56648  -24.44724 4.80959   1.000 26.55614 ? 520 TYR   A HE2  1 
ATOM   3880 H HH   . TYR   B 1 42  ? 0.31843   -23.87905 3.75226   1.000 34.59169 ? 520 TYR   A HH   1 
ATOM   3881 N N    . ALA   B 1 43  ? -8.24004  -24.32530 3.81420   1.000 22.86899 ? 521 ALA   A N    1 
ATOM   3882 C CA   . ALA   B 1 43  ? -9.65240  -24.37077 4.19058   1.000 27.74178 ? 521 ALA   A CA   1 
ATOM   3883 C C    . ALA   B 1 43  ? -9.85254  -23.52952 5.44042   1.000 25.24975 ? 521 ALA   A C    1 
ATOM   3884 O O    . ALA   B 1 43  ? -9.25450  -23.82427 6.48081   1.000 26.17262 ? 521 ALA   A O    1 
ATOM   3885 C CB   . ALA   B 1 43  ? -10.09989 -25.79849 4.44134   1.000 27.15930 ? 521 ALA   A CB   1 
ATOM   3886 H H    . ALA   B 1 43  ? -7.70988  -24.59588 4.43495   1.000 27.39680 ? 521 ALA   A H    1 
ATOM   3887 H HA   . ALA   B 1 43  ? -10.19020 -23.99638 3.47539   1.000 33.24415 ? 521 ALA   A HA   1 
ATOM   3888 H HB1  . ALA   B 1 43  ? -11.03815 -25.79676 4.68744   1.000 32.54517 ? 521 ALA   A HB1  1 
ATOM   3889 H HB2  . ALA   B 1 43  ? -9.97131  -26.31660 3.63144   1.000 32.54517 ? 521 ALA   A HB2  1 
ATOM   3890 H HB3  . ALA   B 1 43  ? -9.56966  -26.17372 5.16173   1.000 32.54517 ? 521 ALA   A HB3  1 
ATOM   3891 N N    . ILE   B 1 44  ? -10.68304 -22.48957 5.33160   1.000 24.49266 ? 522 ILE   A N    1 
ATOM   3892 C CA   . ILE   B 1 44  ? -10.97423 -21.61165 6.45920   1.000 22.03960 ? 522 ILE   A CA   1 
ATOM   3893 C C    . ILE   B 1 44  ? -12.07221 -22.24353 7.31823   1.000 26.12004 ? 522 ILE   A C    1 
ATOM   3894 O O    . ILE   B 1 44  ? -13.13967 -22.60973 6.82178   1.000 22.74500 ? 522 ILE   A O    1 
ATOM   3895 C CB   . ILE   B 1 44  ? -11.36247 -20.20823 5.97729   1.000 24.69544 ? 522 ILE   A CB   1 
ATOM   3896 C CG1  . ILE   B 1 44  ? -10.21714 -19.59592 5.17656   1.000 28.08178 ? 522 ILE   A CG1  1 
ATOM   3897 C CG2  . ILE   B 1 44  ? -11.73571 -19.34068 7.15455   1.000 23.36974 ? 522 ILE   A CG2  1 
ATOM   3898 C CD1  . ILE   B 1 44  ? -10.53540 -18.28101 4.54237   1.000 31.22946 ? 522 ILE   A CD1  1 
ATOM   3899 H H    . ILE   B 1 44  ? -11.09251 -22.27216 4.60725   1.000 29.34521 ? 522 ILE   A H    1 
ATOM   3900 H HA   . ILE   B 1 44  ? -10.18226 -21.53104 7.01345   1.000 26.40153 ? 522 ILE   A HA   1 
ATOM   3901 H HB   . ILE   B 1 44  ? -12.13528 -20.27375 5.39473   1.000 29.58855 ? 522 ILE   A HB   1 
ATOM   3902 H HG12 . ILE   B 1 44  ? -9.46330  -19.45894 5.77143   1.000 33.65215 ? 522 ILE   A HG12 1 
ATOM   3903 H HG13 . ILE   B 1 44  ? -9.97274  -20.21112 4.46755   1.000 33.65215 ? 522 ILE   A HG13 1 
ATOM   3904 H HG21 . ILE   B 1 44  ? -11.85047 -18.42700 6.84972   1.000 27.99771 ? 522 ILE   A HG21 1 
ATOM   3905 H HG22 . ILE   B 1 44  ? -12.56443 -19.66803 7.53791   1.000 27.99771 ? 522 ILE   A HG22 1 
ATOM   3906 H HG23 . ILE   B 1 44  ? -11.02653 -19.38242 7.81501   1.000 27.99771 ? 522 ILE   A HG23 1 
ATOM   3907 H HD11 . ILE   B 1 44  ? -9.85778  -18.07831 3.87856   1.000 37.42937 ? 522 ILE   A HD11 1 
ATOM   3908 H HD12 . ILE   B 1 44  ? -11.40652 -18.33702 4.11938   1.000 37.42937 ? 522 ILE   A HD12 1 
ATOM   3909 H HD13 . ILE   B 1 44  ? -10.54371 -17.59395 5.22704   1.000 37.42937 ? 522 ILE   A HD13 1 
ATOM   3910 N N    . GLU   B 1 45  ? -11.78935 -22.42763 8.60164   1.000 23.32363 ? 523 GLU   A N    1 
ATOM   3911 C CA   . GLU   B 1 45  ? -12.78975 -22.92972 9.53582   1.000 23.81759 ? 523 GLU   A CA   1 
ATOM   3912 C C    . GLU   B 1 45  ? -13.58649 -21.78730 10.14172  1.000 23.94702 ? 523 GLU   A C    1 
ATOM   3913 O O    . GLU   B 1 45  ? -14.81333 -21.86453 10.26886  1.000 22.38129 ? 523 GLU   A O    1 
ATOM   3914 C CB   . GLU   B 1 45  ? -12.11691 -23.75685 10.63243  1.000 24.72452 ? 523 GLU   A CB   1 
ATOM   3915 C CG   . GLU   B 1 45  ? -13.02599 -24.16376 11.77492  1.000 35.27266 ? 523 GLU   A CG   1 
ATOM   3916 C CD   . GLU   B 1 45  ? -12.26795 -24.86579 12.89867  1.000 44.04837 ? 523 GLU   A CD   1 
ATOM   3917 O OE1  . GLU   B 1 45  ? -11.63752 -25.90660 12.60964  1.000 39.32972 ? 523 GLU   A OE1  1 
ATOM   3918 O OE2  . GLU   B 1 45  ? -12.27868 -24.34758 14.04792  1.000 39.72730 ? 523 GLU   A OE2  1 
ATOM   3919 H H    . GLU   B 1 45  ? -11.02299 -22.26889 8.95815   1.000 27.94237 ? 523 GLU   A H    1 
ATOM   3920 H HA   . GLU   B 1 45  ? -13.40511 -23.52083 9.07449   1.000 28.53512 ? 523 GLU   A HA   1 
ATOM   3921 H HB2  . GLU   B 1 45  ? -11.76854 -24.56973 10.23398  1.000 29.62344 ? 523 GLU   A HB2  1 
ATOM   3922 H HB3  . GLU   B 1 45  ? -11.39146 -23.23487 11.00946  1.000 29.62344 ? 523 GLU   A HB3  1 
ATOM   3923 H HG2  . GLU   B 1 45  ? -13.44647 -23.37134 12.14392  1.000 42.28121 ? 523 GLU   A HG2  1 
ATOM   3924 H HG3  . GLU   B 1 45  ? -13.70256 -24.77330 11.44083  1.000 42.28121 ? 523 GLU   A HG3  1 
ATOM   3925 N N    . LYS   B 1 46  ? -12.91954 -20.70636 10.53687  1.000 20.30884 ? 524 LYS   A N    1 
ATOM   3926 C CA   . LYS   B 1 46  ? -13.62548 -19.53813 11.02634  1.000 20.98211 ? 524 LYS   A CA   1 
ATOM   3927 C C    . LYS   B 1 46  ? -12.68068 -18.34426 11.00841  1.000 18.82458 ? 524 LYS   A C    1 
ATOM   3928 O O    . LYS   B 1 46  ? -11.44728 -18.49174 10.93260  1.000 17.47901 ? 524 LYS   A O    1 
ATOM   3929 C CB   . LYS   B 1 46  ? -14.19431 -19.74477 12.42932  1.000 22.16321 ? 524 LYS   A CB   1 
ATOM   3930 C CG   . LYS   B 1 46  ? -13.15626 -20.12606 13.45544  1.000 22.14208 ? 524 LYS   A CG   1 
ATOM   3931 C CD   . LYS   B 1 46  ? -13.74166 -20.20860 14.86939  1.000 24.48530 ? 524 LYS   A CD   1 
ATOM   3932 C CE   . LYS   B 1 46  ? -12.68632 -20.71918 15.85188  1.000 30.09828 ? 524 LYS   A CE   1 
ATOM   3933 N NZ   . LYS   B 1 46  ? -13.20756 -20.74767 17.23795  1.000 35.67130 ? 524 LYS   A NZ   1 
ATOM   3934 H H    . LYS   B 1 46  ? -12.06300 -20.62973 10.52947  1.000 24.32463 ? 524 LYS   A H    1 
ATOM   3935 H HA   . LYS   B 1 46  ? -14.36676 -19.35580 10.42786  1.000 25.13255 ? 524 LYS   A HA   1 
ATOM   3936 H HB2  . LYS   B 1 46  ? -14.61059 -18.91890 12.72182  1.000 26.54987 ? 524 LYS   A HB2  1 
ATOM   3937 H HB3  . LYS   B 1 46  ? -14.85379 -20.45536 12.39692  1.000 26.54987 ? 524 LYS   A HB3  1 
ATOM   3938 H HG2  . LYS   B 1 46  ? -12.78928 -20.99509 13.22957  1.000 26.52451 ? 524 LYS   A HG2  1 
ATOM   3939 H HG3  . LYS   B 1 46  ? -12.45185 -19.45920 13.45892  1.000 26.52451 ? 524 LYS   A HG3  1 
ATOM   3940 H HD2  . LYS   B 1 46  ? -14.03001 -19.32746 15.15462  1.000 29.33637 ? 524 LYS   A HD2  1 
ATOM   3941 H HD3  . LYS   B 1 46  ? -14.49323 -20.82178 14.87561  1.000 29.33637 ? 524 LYS   A HD3  1 
ATOM   3942 H HE2  . LYS   B 1 46  ? -12.42619 -21.62038 15.60474  1.000 36.07195 ? 524 LYS   A HE2  1 
ATOM   3943 H HE3  . LYS   B 1 46  ? -11.91413 -20.13262 15.82788  1.000 36.07195 ? 524 LYS   A HE3  1 
ATOM   3944 H HZ1  . LYS   B 1 46  ? -12.57997 -21.04781 17.79307  1.000 42.75958 ? 524 LYS   A HZ1  1 
ATOM   3945 H HZ2  . LYS   B 1 46  ? -13.44805 -19.92857 17.48962  1.000 42.75958 ? 524 LYS   A HZ2  1 
ATOM   3946 H HZ3  . LYS   B 1 46  ? -13.91604 -21.28421 17.28576  1.000 42.75958 ? 524 LYS   A HZ3  1 
ATOM   3947 N N    . ILE   B 1 47  ? -13.27907 -17.15936 11.05273  1.000 19.50141 ? 525 ILE   A N    1 
ATOM   3948 C CA   . ILE   B 1 47  ? -12.55237 -15.90837 11.20679  1.000 17.67016 ? 525 ILE   A CA   1 
ATOM   3949 C C    . ILE   B 1 47  ? -13.17609 -15.18177 12.38803  1.000 18.82084 ? 525 ILE   A C    1 
ATOM   3950 O O    . ILE   B 1 47  ? -14.40065 -15.11748 12.50731  1.000 17.16753 ? 525 ILE   A O    1 
ATOM   3951 C CB   . ILE   B 1 47  ? -12.59360 -15.02417 9.95260   1.000 18.99996 ? 525 ILE   A CB   1 
ATOM   3952 C CG1  . ILE   B 1 47  ? -12.10010 -15.79951 8.72353   1.000 18.01941 ? 525 ILE   A CG1  1 
ATOM   3953 C CG2  . ILE   B 1 47  ? -11.76355 -13.76661 10.17586  1.000 18.56126 ? 525 ILE   A CG2  1 
ATOM   3954 C CD1  . ILE   B 1 47  ? -12.17442 -15.00579 7.45481   1.000 18.56978 ? 525 ILE   A CD1  1 
ATOM   3955 H H    . ILE   B 1 47  ? -14.13046 -17.05329 10.99369  1.000 23.35570 ? 525 ILE   A H    1 
ATOM   3956 H HA   . ILE   B 1 47  ? -11.61864 -16.09944 11.38717  1.000 21.15820 ? 525 ILE   A HA   1 
ATOM   3957 H HB   . ILE   B 1 47  ? -13.51319 -14.76368 9.78706   1.000 22.75397 ? 525 ILE   A HB   1 
ATOM   3958 H HG12 . ILE   B 1 47  ? -11.17420 -16.05277 8.86311   1.000 21.57731 ? 525 ILE   A HG12 1 
ATOM   3959 H HG13 . ILE   B 1 47  ? -12.64768 -16.59234 8.61186   1.000 21.57731 ? 525 ILE   A HG13 1 
ATOM   3960 H HG21 . ILE   B 1 47  ? -11.82197 -13.20545 9.38682   1.000 22.22753 ? 525 ILE   A HG21 1 
ATOM   3961 H HG22 . ILE   B 1 47  ? -12.11158 -13.29117 10.94640  1.000 22.22753 ? 525 ILE   A HG22 1 
ATOM   3962 H HG23 . ILE   B 1 47  ? -10.84084 -14.02106 10.33322  1.000 22.22753 ? 525 ILE   A HG23 1 
ATOM   3963 H HD11 . ILE   B 1 47  ? -12.04161 -15.60184 6.70116   1.000 22.23775 ? 525 ILE   A HD11 1 
ATOM   3964 H HD12 . ILE   B 1 47  ? -13.04713 -14.58659 7.39521   1.000 22.23775 ? 525 ILE   A HD12 1 
ATOM   3965 H HD13 . ILE   B 1 47  ? -11.48151 -14.32707 7.46586   1.000 22.23775 ? 525 ILE   A HD13 1 
ATOM   3966 N N    . GLU   B 1 48  ? -12.34682 -14.70644 13.29413  1.000 16.00162 ? 526 GLU   A N    1 
ATOM   3967 C CA   . GLU   B 1 48  ? -12.79825 -13.98046 14.47223  1.000 15.83624 ? 526 GLU   A CA   1 
ATOM   3968 C C    . GLU   B 1 48  ? -12.24869 -12.56549 14.46974  1.000 16.81372 ? 526 GLU   A C    1 
ATOM   3969 O O    . GLU   B 1 48  ? -11.09633 -12.33787 14.07963  1.000 17.25686 ? 526 GLU   A O    1 
ATOM   3970 C CB   . GLU   B 1 48  ? -12.35478 -14.69110 15.74935  1.000 16.65095 ? 526 GLU   A CB   1 
ATOM   3971 C CG   . GLU   B 1 48  ? -13.00706 -16.05131 15.95440  1.000 19.55132 ? 526 GLU   A CG   1 
ATOM   3972 C CD   . GLU   B 1 48  ? -12.35740 -16.85882 17.04196  1.000 23.33837 ? 526 GLU   A CD   1 
ATOM   3973 O OE1  . GLU   B 1 48  ? -11.30669 -17.49438 16.79319  1.000 21.81043 ? 526 GLU   A OE1  1 
ATOM   3974 O OE2  . GLU   B 1 48  ? -12.88133 -16.83214 18.17783  1.000 27.13146 ? 526 GLU   A OE2  1 
ATOM   3975 H H    . GLU   B 1 48  ? -11.49218 -14.79207 13.25118  1.000 19.15596 ? 526 GLU   A H    1 
ATOM   3976 H HA   . GLU   B 1 48  ? -13.76657 -13.92548 14.45665  1.000 18.95750 ? 526 GLU   A HA   1 
ATOM   3977 H HB2  . GLU   B 1 48  ? -11.39482 -14.82568 15.71369  1.000 19.93516 ? 526 GLU   A HB2  1 
ATOM   3978 H HB3  . GLU   B 1 48  ? -12.58381 -14.13537 16.51067  1.000 19.93516 ? 526 GLU   A HB3  1 
ATOM   3979 H HG2  . GLU   B 1 48  ? -13.93773 -15.92105 16.19481  1.000 23.41560 ? 526 GLU   A HG2  1 
ATOM   3980 H HG3  . GLU   B 1 48  ? -12.94527 -16.55759 15.12932  1.000 23.41560 ? 526 GLU   A HG3  1 
ATOM   3981 N N    . ARG   B 1 49  ? -13.08723 -11.62066 14.87545  1.000 16.93132 ? 527 ARG   A N    1 
ATOM   3982 C CA   . ARG   B 1 49  ? -12.67823 -10.23727 15.07159  1.000 17.76458 ? 527 ARG   A CA   1 
ATOM   3983 C C    . ARG   B 1 49  ? -12.17987 -10.09626 16.50953  1.000 18.08193 ? 527 ARG   A C    1 
ATOM   3984 O O    . ARG   B 1 49  ? -12.89147 -10.43138 17.46421  1.000 17.70963 ? 527 ARG   A O    1 
ATOM   3985 C CB   . ARG   B 1 49  ? -13.83858 -9.27183  14.81068  1.000 18.45935 ? 527 ARG   A CB   1 
ATOM   3986 C CG   . ARG   B 1 49  ? -13.44923 -7.78481  14.80955  1.000 19.81712 ? 527 ARG   A CG   1 
ATOM   3987 C CD   . ARG   B 1 49  ? -14.69251 -6.87512  14.94466  1.000 23.02453 ? 527 ARG   A CD   1 
ATOM   3988 N NE   . ARG   B 1 49  ? -15.73585 -7.14567  13.96688  1.000 28.13569 ? 527 ARG   A NE   1 
ATOM   3989 C CZ   . ARG   B 1 49  ? -16.96386 -7.55201  14.25902  1.000 27.57416 ? 527 ARG   A CZ   1 
ATOM   3990 N NH1  . ARG   B 1 49  ? -17.36499 -7.73274  15.51346  1.000 22.66530 ? 527 ARG   A NH1  1 
ATOM   3991 N NH2  . ARG   B 1 49  ? -17.82948 -7.75171  13.26929  1.000 29.92182 ? 527 ARG   A NH2  1 
ATOM   3992 H H    . ARG   B 1 49  ? -13.91826 -11.75946 15.04781  1.000 20.27160 ? 527 ARG   A H    1 
ATOM   3993 H HA   . ARG   B 1 49  ? -11.96910 -10.00405 14.45219  1.000 21.27151 ? 527 ARG   A HA   1 
ATOM   3994 H HB2  . ARG   B 1 49  ? -14.21887 -9.47486  13.94173  1.000 22.10523 ? 527 ARG   A HB2  1 
ATOM   3995 H HB3  . ARG   B 1 49  ? -14.50629 -9.39842  15.50281  1.000 22.10523 ? 527 ARG   A HB3  1 
ATOM   3996 H HG2  . ARG   B 1 49  ? -12.85801 -7.60664  15.55762  1.000 23.73456 ? 527 ARG   A HG2  1 
ATOM   3997 H HG3  . ARG   B 1 49  ? -13.00303 -7.56986  13.97552  1.000 23.73456 ? 527 ARG   A HG3  1 
ATOM   3998 H HD2  . ARG   B 1 49  ? -15.07613 -7.00151  15.82657  1.000 27.58345 ? 527 ARG   A HD2  1 
ATOM   3999 H HD3  . ARG   B 1 49  ? -14.41635 -5.95209  14.83217  1.000 27.58345 ? 527 ARG   A HD3  1 
ATOM   4000 H HE   . ARG   B 1 49  ? -15.54128 -7.03353  13.13672  1.000 33.71684 ? 527 ARG   A HE   1 
ATOM   4001 H HH11 . ARG   B 1 49  ? -16.82210 -7.58539  16.16397  1.000 27.15238 ? 527 ARG   A HH11 1 
ATOM   4002 H HH12 . ARG   B 1 49  ? -18.16738 -7.99701  15.67449  1.000 27.15238 ? 527 ARG   A HH12 1 
ATOM   4003 H HH21 . ARG   B 1 49  ? -17.58948 -7.61733  12.45447  1.000 35.86019 ? 527 ARG   A HH21 1 
ATOM   4004 H HH22 . ARG   B 1 49  ? -18.62923 -8.01522  13.44412  1.000 35.86019 ? 527 ARG   A HH22 1 
ATOM   4005 N N    . ILE   B 1 50  ? -10.98501 -9.53965  16.66913  1.000 17.82982 ? 528 ILE   A N    1 
ATOM   4006 C CA   . ILE   B 1 50  ? -10.39906 -9.34548  17.98829  1.000 17.19278 ? 528 ILE   A CA   1 
ATOM   4007 C C    . ILE   B 1 50  ? -10.77165 -7.94477  18.47230  1.000 15.73608 ? 528 ILE   A C    1 
ATOM   4008 O O    . ILE   B 1 50  ? -10.34142 -6.94820  17.89864  1.000 16.04266 ? 528 ILE   A O    1 
ATOM   4009 C CB   . ILE   B 1 50  ? -8.86747  -9.53297  17.93318  1.000 15.83806 ? 528 ILE   A CB   1 
ATOM   4010 C CG1  . ILE   B 1 50  ? -8.51578  -10.95647 17.46597  1.000 17.29924 ? 528 ILE   A CG1  1 
ATOM   4011 C CG2  . ILE   B 1 50  ? -8.24821  -9.24760  19.29873  1.000 15.57295 ? 528 ILE   A CG2  1 
ATOM   4012 C CD1  . ILE   B 1 50  ? -7.14350  -11.09657 16.93626  1.000 21.73112 ? 528 ILE   A CD1  1 
ATOM   4013 H H    . ILE   B 1 50  ? -10.49009 -9.26382  16.02216  1.000 21.34980 ? 528 ILE   A H    1 
ATOM   4014 H HA   . ILE   B 1 50  ? -10.77474 -9.98606  18.61233  1.000 20.58535 ? 528 ILE   A HA   1 
ATOM   4015 H HB   . ILE   B 1 50  ? -8.50474  -8.90253  17.29141  1.000 18.95969 ? 528 ILE   A HB   1 
ATOM   4016 H HG12 . ILE   B 1 50  ? -8.60377  -11.56110 18.21935  1.000 20.71310 ? 528 ILE   A HG12 1 
ATOM   4017 H HG13 . ILE   B 1 50  ? -9.13105  -11.21280 16.76124  1.000 20.71310 ? 528 ILE   A HG13 1 
ATOM   4018 H HG21 . ILE   B 1 50  ? -7.32935  -9.55838  19.29996  1.000 18.64155 ? 528 ILE   A HG21 1 
ATOM   4019 H HG22 . ILE   B 1 50  ? -8.27445  -8.29213  19.46394  1.000 18.64155 ? 528 ILE   A HG22 1 
ATOM   4020 H HG23 . ILE   B 1 50  ? -8.75645  -9.71515  19.97990  1.000 18.64155 ? 528 ILE   A HG23 1 
ATOM   4021 H HD11 . ILE   B 1 50  ? -7.02893  -11.99533 16.58985  1.000 26.03136 ? 528 ILE   A HD11 1 
ATOM   4022 H HD12 . ILE   B 1 50  ? -7.01144  -10.44905 16.22620  1.000 26.03136 ? 528 ILE   A HD12 1 
ATOM   4023 H HD13 . ILE   B 1 50  ? -6.51027  -10.93514 17.65310  1.000 26.03136 ? 528 ILE   A HD13 1 
ATOM   4024 N N    . GLN   B 1 51  ? -11.54861 -7.87015  19.56088  1.000 15.67234 ? 529 GLN   A N    1 
ATOM   4025 C CA   . GLN   B 1 51  ? -11.98247 -6.61208  20.14644  1.000 18.56222 ? 529 GLN   A CA   1 
ATOM   4026 C C    . GLN   B 1 51  ? -11.29847 -6.49686  21.50117  1.000 19.48225 ? 529 GLN   A C    1 
ATOM   4027 O O    . GLN   B 1 51  ? -11.80790 -6.95542  22.51725  1.000 18.51371 ? 529 GLN   A O    1 
ATOM   4028 C CB   . GLN   B 1 51  ? -13.49729 -6.54712  20.27844  1.000 17.85051 ? 529 GLN   A CB   1 
ATOM   4029 C CG   . GLN   B 1 51  ? -14.21140 -6.68414  18.91876  1.000 20.69666 ? 529 GLN   A CG   1 
ATOM   4030 C CD   . GLN   B 1 51  ? -15.70985 -6.42560  18.96209  1.000 21.56707 ? 529 GLN   A CD   1 
ATOM   4031 O OE1  . GLN   B 1 51  ? -16.36402 -6.47737  17.93431  1.000 19.88524 ? 529 GLN   A OE1  1 
ATOM   4032 N NE2  . GLN   B 1 51  ? -16.24445 -6.12938  20.13891  1.000 23.30804 ? 529 GLN   A NE2  1 
ATOM   4033 H H    . GLN   B 1 51  ? -11.84105 -8.55953  19.98378  1.000 18.76082 ? 529 GLN   A H    1 
ATOM   4034 H HA   . GLN   B 1 51  ? -11.70195 -5.87732  19.57870  1.000 22.22868 ? 529 GLN   A HA   1 
ATOM   4035 H HB2  . GLN   B 1 51  ? -13.79701 -7.27032  20.85119  1.000 21.37463 ? 529 GLN   A HB2  1 
ATOM   4036 H HB3  . GLN   B 1 51  ? -13.74557 -5.69293  20.66523  1.000 21.37463 ? 529 GLN   A HB3  1 
ATOM   4037 H HG2  . GLN   B 1 51  ? -13.82268 -6.04636  18.29986  1.000 24.79001 ? 529 GLN   A HG2  1 
ATOM   4038 H HG3  . GLN   B 1 51  ? -14.08016 -7.58737  18.59037  1.000 24.79001 ? 529 GLN   A HG3  1 
ATOM   4039 H HE21 . GLN   B 1 51  ? -15.74709 -6.08964  20.83938  1.000 27.92367 ? 529 GLN   A HE21 1 
ATOM   4040 H HE22 . GLN   B 1 51  ? -17.08852 -5.97702  20.20165  1.000 27.92367 ? 529 GLN   A HE22 1 
ATOM   4041 N N    . ASN   B 1 52  ? -10.10825 -5.90642  21.50436  1.000 15.36688 ? 530 ASN   A N    1 
ATOM   4042 C CA   . ASN   B 1 52  ? -9.30679  -5.74944  22.71977  1.000 16.97734 ? 530 ASN   A CA   1 
ATOM   4043 C C    . ASN   B 1 52  ? -9.14643  -4.24160  22.91775  1.000 17.94930 ? 530 ASN   A C    1 
ATOM   4044 O O    . ASN   B 1 52  ? -8.35136  -3.60339  22.21371  1.000 16.57153 ? 530 ASN   A O    1 
ATOM   4045 C CB   . ASN   B 1 52  ? -7.98273  -6.46663  22.59147  1.000 16.58720 ? 530 ASN   A CB   1 
ATOM   4046 C CG   . ASN   B 1 52  ? -7.14538  -6.38114  23.85826  1.000 18.55763 ? 530 ASN   A CG   1 
ATOM   4047 O OD1  . ASN   B 1 52  ? -7.16627  -5.38300  24.53791  1.000 15.92554 ? 530 ASN   A OD1  1 
ATOM   4048 N ND2  . ASN   B 1 52  ? -6.45990  -7.46461  24.19446  1.000 17.93582 ? 530 ASN   A ND2  1 
ATOM   4049 H H    . ASN   B 1 52  ? -9.73416  -5.58126  20.80156  1.000 18.39428 ? 530 ASN   A H    1 
ATOM   4050 H HA   . ASN   B 1 52  ? -9.75735  -6.12568  23.49200  1.000 20.32682 ? 530 ASN   A HA   1 
ATOM   4051 H HB2  . ASN   B 1 52  ? -8.14732  -7.40376  22.40281  1.000 19.85865 ? 530 ASN   A HB2  1 
ATOM   4052 H HB3  . ASN   B 1 52  ? -7.47495  -6.06680  21.86815  1.000 19.85865 ? 530 ASN   A HB3  1 
ATOM   4053 H HD21 . ASN   B 1 52  ? -5.97247  -7.46241  24.90298  1.000 21.47699 ? 530 ASN   A HD21 1 
ATOM   4054 H HD22 . ASN   B 1 52  ? -6.50257  -8.16981  23.70407  1.000 21.47699 ? 530 ASN   A HD22 1 
ATOM   4055 N N    . ALA   B 1 53  ? -9.93420  -3.66593  23.84129  1.000 17.05807 ? 531 ALA   A N    1 
ATOM   4056 C CA   . ALA   B 1 53  ? -9.96160  -2.21115  23.96980  1.000 16.72267 ? 531 ALA   A CA   1 
ATOM   4057 C C    . ALA   B 1 53  ? -8.61329  -1.64081  24.38284  1.000 15.80529 ? 531 ALA   A C    1 
ATOM   4058 O O    . ALA   B 1 53  ? -8.19623  -0.59782  23.86909  1.000 15.43458 ? 531 ALA   A O    1 
ATOM   4059 C CB   . ALA   B 1 53  ? -11.01419 -1.77971  24.99933  1.000 19.48629 ? 531 ALA   A CB   1 
ATOM   4060 H H    . ALA   B 1 53  ? -10.44632 -4.08812  24.38817  1.000 20.42369 ? 531 ALA   A H    1 
ATOM   4061 H HA   . ALA   B 1 53  ? -10.19732 -1.85421  23.09920  1.000 20.02122 ? 531 ALA   A HA   1 
ATOM   4062 H HB1  . ALA   B 1 53  ? -11.01546 -0.81181  25.06305  1.000 23.33757 ? 531 ALA   A HB1  1 
ATOM   4063 H HB2  . ALA   B 1 53  ? -11.88549 -2.09334  24.71057  1.000 23.33757 ? 531 ALA   A HB2  1 
ATOM   4064 H HB3  . ALA   B 1 53  ? -10.79159 -2.16758  25.86008  1.000 23.33757 ? 531 ALA   A HB3  1 
ATOM   4065 N N    . PHE   B 1 54  ? -7.94128  -2.28677  25.33877  1.000 17.04020 ? 532 PHE   A N    1 
ATOM   4066 C CA   . PHE   B 1 54  ? -6.66702  -1.75987  25.82572  1.000 17.23117 ? 532 PHE   A CA   1 
ATOM   4067 C C    . PHE   B 1 54  ? -5.61634  -1.74629  24.72681  1.000 17.04423 ? 532 PHE   A C    1 
ATOM   4068 O O    . PHE   B 1 54  ? -4.89918  -0.76434  24.55797  1.000 16.16757 ? 532 PHE   A O    1 
ATOM   4069 C CB   . PHE   B 1 54  ? -6.17736  -2.57127  27.02515  1.000 16.59332 ? 532 PHE   A CB   1 
ATOM   4070 C CG   . PHE   B 1 54  ? -6.89533  -2.25309  28.32845  1.000 18.25155 ? 532 PHE   A CG   1 
ATOM   4071 C CD1  . PHE   B 1 54  ? -7.92513  -1.32481  28.37698  1.000 19.85283 ? 532 PHE   A CD1  1 
ATOM   4072 C CD2  . PHE   B 1 54  ? -6.52224  -2.88927  29.50154  1.000 19.04335 ? 532 PHE   A CD2  1 
ATOM   4073 C CE1  . PHE   B 1 54  ? -8.56788  -1.02842  29.57492  1.000 21.26030 ? 532 PHE   A CE1  1 
ATOM   4074 C CE2  . PHE   B 1 54  ? -7.17203  -2.61768  30.68739  1.000 20.50304 ? 532 PHE   A CE2  1 
ATOM   4075 C CZ   . PHE   B 1 54  ? -8.17668  -1.69148  30.73453  1.000 18.62493 ? 532 PHE   A CZ   1 
ATOM   4076 H H    . PHE   B 1 54  ? -8.19650  -3.01721  25.71416  1.000 20.40225 ? 532 PHE   A H    1 
ATOM   4077 H HA   . PHE   B 1 54  ? -6.80847  -0.84623  26.11923  1.000 20.63142 ? 532 PHE   A HA   1 
ATOM   4078 H HB2  . PHE   B 1 54  ? -6.31155  -3.51350  26.83783  1.000 19.86600 ? 532 PHE   A HB2  1 
ATOM   4079 H HB3  . PHE   B 1 54  ? -5.23359  -2.39045  27.15749  1.000 19.86600 ? 532 PHE   A HB3  1 
ATOM   4080 H HD1  . PHE   B 1 54  ? -8.19004  -0.89386  27.59660  1.000 23.77741 ? 532 PHE   A HD1  1 
ATOM   4081 H HD2  . PHE   B 1 54  ? -5.82623  -3.50597  29.48912  1.000 22.80603 ? 532 PHE   A HD2  1 
ATOM   4082 H HE1  . PHE   B 1 54  ? -9.24937  -0.39610  29.60045  1.000 25.46638 ? 532 PHE   A HE1  1 
ATOM   4083 H HE2  . PHE   B 1 54  ? -6.92454  -3.06873  31.46212  1.000 24.55766 ? 532 PHE   A HE2  1 
ATOM   4084 H HZ   . PHE   B 1 54  ? -8.59886  -1.50441  31.54179  1.000 22.30393 ? 532 PHE   A HZ   1 
ATOM   4085 N N    . LEU   B 1 55  ? -5.48865  -2.84842  24.00323  1.000 16.81801 ? 533 LEU   A N    1 
ATOM   4086 C CA   . LEU   B 1 55  ? -4.51668  -2.92959  22.93170  1.000 15.49147 ? 533 LEU   A CA   1 
ATOM   4087 C C    . LEU   B 1 55  ? -4.81803  -1.91612  21.84693  1.000 15.47601 ? 533 LEU   A C    1 
ATOM   4088 O O    . LEU   B 1 55  ? -3.89167  -1.31792  21.27155  1.000 15.97159 ? 533 LEU   A O    1 
ATOM   4089 C CB   . LEU   B 1 55  ? -4.47263  -4.35353  22.34507  1.000 17.84166 ? 533 LEU   A CB   1 
ATOM   4090 C CG   . LEU   B 1 55  ? -3.81248  -5.46050  23.11745  1.000 20.28125 ? 533 LEU   A CG   1 
ATOM   4091 C CD1  . LEU   B 1 55  ? -3.89833  -6.77145  22.32274  1.000 18.98542 ? 533 LEU   A CD1  1 
ATOM   4092 C CD2  . LEU   B 1 55  ? -2.32832  -5.14531  23.42940  1.000 20.73261 ? 533 LEU   A CD2  1 
ATOM   4093 H H    . LEU   B 1 55  ? -5.95373  -3.56336  24.11346  1.000 20.13563 ? 533 LEU   A H    1 
ATOM   4094 H HA   . LEU   B 1 55  ? -3.63882  -2.73590  23.29605  1.000 18.54378 ? 533 LEU   A HA   1 
ATOM   4095 H HB2  . LEU   B 1 55  ? -5.39021  -4.63361  22.20188  1.000 21.36401 ? 533 LEU   A HB2  1 
ATOM   4096 H HB3  . LEU   B 1 55  ? -4.00578  -4.30018  21.49648  1.000 21.36401 ? 533 LEU   A HB3  1 
ATOM   4097 H HG   . LEU   B 1 55  ? -4.27684  -5.55561  23.96375  1.000 24.29152 ? 533 LEU   A HG   1 
ATOM   4098 H HD11 . LEU   B 1 55  ? -3.50488  -7.48561  22.84816  1.000 22.73652 ? 533 LEU   A HD11 1 
ATOM   4099 H HD12 . LEU   B 1 55  ? -4.83016  -6.96974  22.14034  1.000 22.73652 ? 533 LEU   A HD12 1 
ATOM   4100 H HD13 . LEU   B 1 55  ? -3.41291  -6.66790  21.48934  1.000 22.73652 ? 533 LEU   A HD13 1 
ATOM   4101 H HD21 . LEU   B 1 55  ? -1.91770  -5.92608  23.83276  1.000 24.83315 ? 533 LEU   A HD21 1 
ATOM   4102 H HD22 . LEU   B 1 55  ? -1.87251  -4.92163  22.60291  1.000 24.83315 ? 533 LEU   A HD22 1 
ATOM   4103 H HD23 . LEU   B 1 55  ? -2.28701  -4.39546  24.04334  1.000 24.83315 ? 533 LEU   A HD23 1 
ATOM   4104 N N    . TRP   B 1 56  ? -6.10342  -1.74092  21.52751  1.000 15.12168 ? 534 TRP   A N    1 
ATOM   4105 C CA   . TRP   B 1 56  ? -6.49218  -0.79975  20.50155  1.000 15.60002 ? 534 TRP   A CA   1 
ATOM   4106 C C    . TRP   B 1 56  ? -6.11216  0.60661   20.94021  1.000 15.35519 ? 534 TRP   A C    1 
ATOM   4107 O O    . TRP   B 1 56  ? -5.57662  1.38723   20.16620  1.000 13.59597 ? 534 TRP   A O    1 
ATOM   4108 C CB   . TRP   B 1 56  ? -7.99700  -0.89502  20.24073  1.000 17.09010 ? 534 TRP   A CB   1 
ATOM   4109 C CG   . TRP   B 1 56  ? -8.51366  0.06792   19.25067  1.000 18.68528 ? 534 TRP   A CG   1 
ATOM   4110 C CD1  . TRP   B 1 56  ? -9.15287  1.25659   19.51069  1.000 23.97767 ? 534 TRP   A CD1  1 
ATOM   4111 C CD2  . TRP   B 1 56  ? -8.40285  -0.02288  17.83238  1.000 19.98304 ? 534 TRP   A CD2  1 
ATOM   4112 N NE1  . TRP   B 1 56  ? -9.47409  1.89460   18.32781  1.000 24.61216 ? 534 TRP   A NE1  1 
ATOM   4113 C CE2  . TRP   B 1 56  ? -9.01775  1.13107   17.28450  1.000 24.02733 ? 534 TRP   A CE2  1 
ATOM   4114 C CE3  . TRP   B 1 56  ? -7.84703  -0.96355  16.96722  1.000 24.30639 ? 534 TRP   A CE3  1 
ATOM   4115 C CZ2  . TRP   B 1 56  ? -9.09872  1.35377   15.91978  1.000 27.05684 ? 534 TRP   A CZ2  1 
ATOM   4116 C CZ3  . TRP   B 1 56  ? -7.93825  -0.73464  15.59084  1.000 28.38795 ? 534 TRP   A CZ3  1 
ATOM   4117 C CH2  . TRP   B 1 56  ? -8.55500  0.40898   15.08872  1.000 29.13857 ? 534 TRP   A CH2  1 
ATOM   4118 H H    . TRP   B 1 56  ? -6.76061  -2.15748  21.89381  1.000 18.10003 ? 534 TRP   A H    1 
ATOM   4119 H HA   . TRP   B 1 56  ? -6.03949  -1.01164  19.67024  1.000 18.67404 ? 534 TRP   A HA   1 
ATOM   4120 H HB2  . TRP   B 1 56  ? -8.19723  -1.78589  19.91339  1.000 20.46214 ? 534 TRP   A HB2  1 
ATOM   4121 H HB3  . TRP   B 1 56  ? -8.46511  -0.73517  21.07512  1.000 20.46214 ? 534 TRP   A HB3  1 
ATOM   4122 H HD1  . TRP   B 1 56  ? -9.34192  1.58426   20.36027  1.000 28.72722 ? 534 TRP   A HD1  1 
ATOM   4123 H HE1  . TRP   B 1 56  ? -9.89003  2.64407   18.25787  1.000 29.48860 ? 534 TRP   A HE1  1 
ATOM   4124 H HE3  . TRP   B 1 56  ? -7.42605  -1.72440  17.29704  1.000 29.12168 ? 534 TRP   A HE3  1 
ATOM   4125 H HZ2  . TRP   B 1 56  ? -9.50727  2.11683   15.57959  1.000 32.42222 ? 534 TRP   A HZ2  1 
ATOM   4126 H HZ3  . TRP   B 1 56  ? -7.58061  -1.35730  14.99982  1.000 34.01955 ? 534 TRP   A HZ3  1 
ATOM   4127 H HH2  . TRP   B 1 56  ? -8.59889  0.53441   14.16826  1.000 34.92030 ? 534 TRP   A HH2  1 
ATOM   4128 N N    . GLN   B 1 57  ? -6.42607  0.95438   22.18726  1.000 14.09887 ? 535 GLN   A N    1 
ATOM   4129 C CA   . GLN   B 1 57  ? -6.10538  2.29767   22.66811  1.000 15.19468 ? 535 GLN   A CA   1 
ATOM   4130 C C    . GLN   B 1 57  ? -4.60615  2.57876   22.58108  1.000 15.04198 ? 535 GLN   A C    1 
ATOM   4131 O O    . GLN   B 1 57  ? -4.19181  3.61766   22.07290  1.000 15.35385 ? 535 GLN   A O    1 
ATOM   4132 C CB   . GLN   B 1 57  ? -6.59409  2.45290   24.10165  1.000 17.73080 ? 535 GLN   A CB   1 
ATOM   4133 C CG   . GLN   B 1 57  ? -6.46798  3.90497   24.62066  1.000 25.09615 ? 535 GLN   A CG   1 
ATOM   4134 C CD   . GLN   B 1 57  ? -6.93292  4.04561   26.05980  1.000 31.19281 ? 535 GLN   A CD   1 
ATOM   4135 O OE1  . GLN   B 1 57  ? -6.92098  3.07473   26.82651  1.000 31.33433 ? 535 GLN   A OE1  1 
ATOM   4136 N NE2  . GLN   B 1 57  ? -7.36533  5.25485   26.42903  1.000 33.43804 ? 535 GLN   A NE2  1 
ATOM   4137 H H    . GLN   B 1 57  ? -6.81492  0.44530   22.76105  1.000 16.87265 ? 535 GLN   A H    1 
ATOM   4138 H HA   . GLN   B 1 57  ? -6.56142  2.94771   22.11099  1.000 18.18763 ? 535 GLN   A HA   1 
ATOM   4139 H HB2  . GLN   B 1 57  ? -7.52884  2.19767   24.14623  1.000 21.23098 ? 535 GLN   A HB2  1 
ATOM   4140 H HB3  . GLN   B 1 57  ? -6.06586  1.88007   24.67936  1.000 21.23098 ? 535 GLN   A HB3  1 
ATOM   4141 H HG2  . GLN   B 1 57  ? -5.53856  4.17894   24.57564  1.000 30.06939 ? 535 GLN   A HG2  1 
ATOM   4142 H HG3  . GLN   B 1 57  ? -7.01280  4.48800   24.06916  1.000 30.06939 ? 535 GLN   A HG3  1 
ATOM   4143 H HE21 . GLN   B 1 57  ? -7.36960  5.90157   25.86217  1.000 40.07966 ? 535 GLN   A HE21 1 
ATOM   4144 H HE22 . GLN   B 1 57  ? -7.63936  5.38638   27.23352  1.000 40.07966 ? 535 GLN   A HE22 1 
ATOM   4145 N N    . SER   B 1 58  ? -3.77013  1.65721   23.09607  1.000 14.24210 ? 536 SER   A N    1 
ATOM   4146 C CA   . SER   B 1 58  ? -2.31900  1.87837   23.07655  1.000 16.30545 ? 536 SER   A CA   1 
ATOM   4147 C C    . SER   B 1 58  ? -1.78505  1.95159   21.65346  1.000 16.37051 ? 536 SER   A C    1 
ATOM   4148 O O    . SER   B 1 58  ? -0.92054  2.78699   21.33988  1.000 14.69693 ? 536 SER   A O    1 
ATOM   4149 C CB   . SER   B 1 58  ? -1.61468  0.76797   23.86022  1.000 19.60717 ? 536 SER   A CB   1 
ATOM   4150 O OG   . SER   B 1 58  ? -1.91224  0.87522   25.23786  1.000 21.61981 ? 536 SER   A OG   1 
ATOM   4151 H H    . SER   B 1 58  ? -4.01507  0.91427   23.45334  1.000 17.04453 ? 536 SER   A H    1 
ATOM   4152 H HA   . SER   B 1 58  ? -2.12586  2.72526   23.50827  1.000 19.52055 ? 536 SER   A HA   1 
ATOM   4153 H HB2  . SER   B 1 58  ? -1.92009  -0.09340  23.53515  1.000 23.48262 ? 536 SER   A HB2  1 
ATOM   4154 H HB3  . SER   B 1 58  ? -0.65626  0.84910   23.73475  1.000 23.48262 ? 536 SER   A HB3  1 
ATOM   4155 H HG   . SER   B 1 58  ? -1.51572  0.27056   25.66535  1.000 25.89779 ? 536 SER   A HG   1 
ATOM   4156 N N    . TYR   B 1 59  ? -2.32331  1.11467   20.76250  1.000 16.03245 ? 537 TYR   A N    1 
ATOM   4157 C CA   . TYR   B 1 59  ? -1.94708  1.15445   19.34728  1.000 16.62667 ? 537 TYR   A CA   1 
ATOM   4158 C C    . TYR   B 1 59  ? -2.33924  2.47807   18.68168  1.000 15.92575 ? 537 TYR   A C    1 
ATOM   4159 O O    . TYR   B 1 59  ? -1.54210  3.10160   17.94671  1.000 15.27011 ? 537 TYR   A O    1 
ATOM   4160 C CB   . TYR   B 1 59  ? -2.60944  -0.03090  18.60451  1.000 14.33209 ? 537 TYR   A CB   1 
ATOM   4161 C CG   . TYR   B 1 59  ? -2.35891  -0.01315  17.11909  1.000 15.89015 ? 537 TYR   A CG   1 
ATOM   4162 C CD1  . TYR   B 1 59  ? -1.22598  -0.62368  16.59618  1.000 15.05729 ? 537 TYR   A CD1  1 
ATOM   4163 C CD2  . TYR   B 1 59  ? -3.24893  0.58051   16.24641  1.000 15.90854 ? 537 TYR   A CD2  1 
ATOM   4164 C CE1  . TYR   B 1 59  ? -0.98627  -0.61323  15.22023  1.000 14.27064 ? 537 TYR   A CE1  1 
ATOM   4165 C CE2  . TYR   B 1 59  ? -3.02058  0.58628   14.88130  1.000 16.71155 ? 537 TYR   A CE2  1 
ATOM   4166 C CZ   . TYR   B 1 59  ? -1.86908  -0.01960  14.37967  1.000 15.40211 ? 537 TYR   A CZ   1 
ATOM   4167 O OH   . TYR   B 1 59  ? -1.65244  -0.00629  13.03033  1.000 15.67486 ? 537 TYR   A OH   1 
ATOM   4168 H H    . TYR   B 1 59  ? -2.90899  0.51379   20.95100  1.000 19.19296 ? 537 TYR   A H    1 
ATOM   4169 H HA   . TYR   B 1 59  ? -0.98251  1.07152   19.28707  1.000 19.90602 ? 537 TYR   A HA   1 
ATOM   4170 H HB2  . TYR   B 1 59  ? -2.25352  -0.86131  18.95755  1.000 17.15252 ? 537 TYR   A HB2  1 
ATOM   4171 H HB3  . TYR   B 1 59  ? -3.56834  0.00585   18.74617  1.000 17.15252 ? 537 TYR   A HB3  1 
ATOM   4172 H HD1  . TYR   B 1 59  ? -0.62257  -1.04252  17.16658  1.000 18.02276 ? 537 TYR   A HD1  1 
ATOM   4173 H HD2  . TYR   B 1 59  ? -4.01650  0.98420   16.58221  1.000 19.04427 ? 537 TYR   A HD2  1 
ATOM   4174 H HE1  . TYR   B 1 59  ? -0.21938  -1.01438  14.87984  1.000 17.07878 ? 537 TYR   A HE1  1 
ATOM   4175 H HE2  . TYR   B 1 59  ? -3.62856  0.98988   14.30478  1.000 20.00788 ? 537 TYR   A HE2  1 
ATOM   4176 H HH   . TYR   B 1 59  ? -2.30764  0.34311   12.63760  1.000 18.76385 ? 537 TYR   A HH   1 
ATOM   4177 N N    . GLN   B 1 60  ? -3.55804  2.95618   18.94927  1.000 15.76900 ? 538 GLN   A N    1 
ATOM   4178 C CA   . GLN   B 1 60  ? -3.99997  4.19809   18.30294  1.000 17.17663 ? 538 GLN   A CA   1 
ATOM   4179 C C    . GLN   B 1 60  ? -3.20042  5.39740   18.78877  1.000 17.81081 ? 538 GLN   A C    1 
ATOM   4180 O O    . GLN   B 1 60  ? -2.92459  6.32321   18.01222  1.000 16.04106 ? 538 GLN   A O    1 
ATOM   4181 C CB   . GLN   B 1 60  ? -5.51021  4.42058   18.53318  1.000 19.67326 ? 538 GLN   A CB   1 
ATOM   4182 C CG   . GLN   B 1 60  ? -6.38669  3.46068   17.74016  1.000 19.05060 ? 538 GLN   A CG   1 
ATOM   4183 C CD   . GLN   B 1 60  ? -6.16963  3.60699   16.24604  1.000 21.86776 ? 538 GLN   A CD   1 
ATOM   4184 O OE1  . GLN   B 1 60  ? -6.01920  4.69978   15.73782  1.000 24.06771 ? 538 GLN   A OE1  1 
ATOM   4185 N NE2  . GLN   B 1 60  ? -6.10808  2.47705   15.54738  1.000 23.01556 ? 538 GLN   A NE2  1 
ATOM   4186 H H    . GLN   B 1 60  ? -4.12904  2.59527   19.48153  1.000 18.87682 ? 538 GLN   A H    1 
ATOM   4187 H HA   . GLN   B 1 60  ? -3.86140  4.11480   17.34651  1.000 20.56597 ? 538 GLN   A HA   1 
ATOM   4188 H HB2  . GLN   B 1 60  ? -5.70597  4.29463   19.47484  1.000 23.56193 ? 538 GLN   A HB2  1 
ATOM   4189 H HB3  . GLN   B 1 60  ? -5.73876  5.32426   18.26479  1.000 23.56193 ? 538 GLN   A HB3  1 
ATOM   4190 H HG2  . GLN   B 1 60  ? -6.17132  2.54882   17.99118  1.000 22.81474 ? 538 GLN   A HG2  1 
ATOM   4191 H HG3  . GLN   B 1 60  ? -7.31932  3.64608   17.93185  1.000 22.81474 ? 538 GLN   A HG3  1 
ATOM   4192 H HE21 . GLN   B 1 60  ? -6.19002  1.71969   15.94650  1.000 27.57269 ? 538 GLN   A HE21 1 
ATOM   4193 H HE22 . GLN   B 1 60  ? -5.98635  2.50372   14.69645  1.000 27.57269 ? 538 GLN   A HE22 1 
ATOM   4194 N N    . VAL   B 1 61  ? -2.78594  5.38025   20.05654  1.000 16.03940 ? 539 VAL   A N    1 
ATOM   4195 C CA   . VAL   B 1 61  ? -1.91135  6.42332   20.55828  1.000 18.08441 ? 539 VAL   A CA   1 
ATOM   4196 C C    . VAL   B 1 61  ? -0.60405  6.41295   19.78717  1.000 15.52907 ? 539 VAL   A C    1 
ATOM   4197 O O    . VAL   B 1 61  ? -0.12675  7.44917   19.30614  1.000 15.77067 ? 539 VAL   A O    1 
ATOM   4198 C CB   . VAL   B 1 61  ? -1.68512  6.24586   22.07206  1.000 16.75233 ? 539 VAL   A CB   1 
ATOM   4199 C CG1  . VAL   B 1 61  ? -0.56148  7.19586   22.55191  1.000 17.04722 ? 539 VAL   A CG1  1 
ATOM   4200 C CG2  . VAL   B 1 61  ? -2.95386  6.50048   22.83492  1.000 20.45975 ? 539 VAL   A CG2  1 
ATOM   4201 H H    . VAL   B 1 61  ? -2.99734  4.78042   20.63543  1.000 19.20129 ? 539 VAL   A H    1 
ATOM   4202 H HA   . VAL   B 1 61  ? -2.33369  7.28582   20.42178  1.000 21.65531 ? 539 VAL   A HA   1 
ATOM   4203 H HB   . VAL   B 1 61  ? -1.41407  5.33095   22.24631  1.000 20.05682 ? 539 VAL   A HB   1 
ATOM   4204 H HG11 . VAL   B 1 61  ? -0.60836  7.27819   23.51727  1.000 20.41067 ? 539 VAL   A HG11 1 
ATOM   4205 H HG12 . VAL   B 1 61  ? 0.29694   6.82590   22.29278  1.000 20.41067 ? 539 VAL   A HG12 1 
ATOM   4206 H HG13 . VAL   B 1 61  ? -0.68519  8.06502   22.13941  1.000 20.41067 ? 539 VAL   A HG13 1 
ATOM   4207 H HG21 . VAL   B 1 61  ? -2.86964  6.12083   23.72355  1.000 24.50571 ? 539 VAL   A HG21 1 
ATOM   4208 H HG22 . VAL   B 1 61  ? -3.09865  7.45763   22.89649  1.000 24.50571 ? 539 VAL   A HG22 1 
ATOM   4209 H HG23 . VAL   B 1 61  ? -3.69347  6.08355   22.36583  1.000 24.50571 ? 539 VAL   A HG23 1 
ATOM   4210 N N    . LYS   B 1 62  ? -0.02726  5.24255   19.62344  1.000 16.11336 ? 540 LYS   A N    1 
ATOM   4211 C CA   . LYS   B 1 62  ? 1.22999   5.14563   18.87012  1.000 15.94058 ? 540 LYS   A CA   1 
ATOM   4212 C C    . LYS   B 1 62  ? 1.03349   5.57237   17.41100  1.000 16.10132 ? 540 LYS   A C    1 
ATOM   4213 O O    . LYS   B 1 62  ? 1.89833   6.23085   16.81192  1.000 17.19156 ? 540 LYS   A O    1 
ATOM   4214 C CB   . LYS   B 1 62  ? 1.78244   3.72862   18.95698  1.000 18.91400 ? 540 LYS   A CB   1 
ATOM   4215 C CG   . LYS   B 1 62  ? 3.09565   3.53635   18.19051  1.000 27.72256 ? 540 LYS   A CG   1 
ATOM   4216 C CD   . LYS   B 1 62  ? 4.18930   4.47983   18.69537  1.000 30.01094 ? 540 LYS   A CD   1 
ATOM   4217 C CE   . LYS   B 1 62  ? 5.53813   4.19597   18.02629  1.000 39.67138 ? 540 LYS   A CE   1 
ATOM   4218 N NZ   . LYS   B 1 62  ? 6.63923   4.98204   18.65428  1.000 48.85313 ? 540 LYS   A NZ   1 
ATOM   4219 H H    . LYS   B 1 62  ? -0.32676  4.49582   19.92724  1.000 19.29004 ? 540 LYS   A H    1 
ATOM   4220 H HA   . LYS   B 1 62  ? 1.88441   5.74151   19.26706  1.000 19.08271 ? 540 LYS   A HA   1 
ATOM   4221 H HB2  . LYS   B 1 62  ? 1.94778   3.51395   19.88836  1.000 22.65082 ? 540 LYS   A HB2  1 
ATOM   4222 H HB3  . LYS   B 1 62  ? 1.12921   3.11498   18.58599  1.000 22.65082 ? 540 LYS   A HB3  1 
ATOM   4223 H HG2  . LYS   B 1 62  ? 3.40389   2.62400   18.30669  1.000 33.22109 ? 540 LYS   A HG2  1 
ATOM   4224 H HG3  . LYS   B 1 62  ? 2.94719   3.71910   17.24952  1.000 33.22109 ? 540 LYS   A HG3  1 
ATOM   4225 H HD2  . LYS   B 1 62  ? 3.93874   5.39571   18.49718  1.000 35.96714 ? 540 LYS   A HD2  1 
ATOM   4226 H HD3  . LYS   B 1 62  ? 4.29491   4.36452   19.65269  1.000 35.96714 ? 540 LYS   A HD3  1 
ATOM   4227 H HE2  . LYS   B 1 62  ? 5.74803   3.25313   18.11510  1.000 47.55967 ? 540 LYS   A HE2  1 
ATOM   4228 H HE3  . LYS   B 1 62  ? 5.48797   4.43776   17.08825  1.000 47.55967 ? 540 LYS   A HE3  1 
ATOM   4229 H HZ1  . LYS   B 1 62  ? 6.69268   4.79153   19.52201  1.000 58.57777 ? 540 LYS   A HZ1  1 
ATOM   4230 H HZ2  . LYS   B 1 62  ? 7.41508   4.78266   18.26647  1.000 58.57777 ? 540 LYS   A HZ2  1 
ATOM   4231 H HZ3  . LYS   B 1 62  ? 6.48407   5.85320   18.55886  1.000 58.57777 ? 540 LYS   A HZ3  1 
ATOM   4232 N N    . LYS   B 1 63  ? -0.10712  5.22545   16.82156  1.000 15.43679 ? 541 LYS   A N    1 
ATOM   4233 C CA   . LYS   B 1 63  ? -0.37039  5.65574   15.45677  1.000 16.44025 ? 541 LYS   A CA   1 
ATOM   4234 C C    . LYS   B 1 63  ? -0.43459  7.17580   15.36004  1.000 16.17410 ? 541 LYS   A C    1 
ATOM   4235 O O    . LYS   B 1 63  ? 0.14847   7.77548   14.43372  1.000 15.78327 ? 541 LYS   A O    1 
ATOM   4236 C CB   . LYS   B 1 63  ? -1.66223  5.01294   14.93671  1.000 16.70495 ? 541 LYS   A CB   1 
ATOM   4237 C CG   . LYS   B 1 63  ? -2.02324  5.48996   13.52570  1.000 19.06201 ? 541 LYS   A CG   1 
ATOM   4238 C CD   . LYS   B 1 63  ? -3.31564  4.83099   13.02730  1.000 19.32662 ? 541 LYS   A CD   1 
ATOM   4239 C CE   . LYS   B 1 63  ? -3.56271  5.13666   11.56560  1.000 27.51585 ? 541 LYS   A CE   1 
ATOM   4240 N NZ   . LYS   B 1 63  ? -3.73256  6.60072   11.30337  1.000 30.20043 ? 541 LYS   A NZ   1 
ATOM   4241 H H    . LYS   B 1 63  ? -0.72882  4.75314   17.18214  1.000 18.47817 ? 541 LYS   A H    1 
ATOM   4242 H HA   . LYS   B 1 63  ? 0.35654   5.35398   14.88983  1.000 19.68232 ? 541 LYS   A HA   1 
ATOM   4243 H HB2  . LYS   B 1 63  ? -1.54912  4.04991   14.91038  1.000 19.99995 ? 541 LYS   A HB2  1 
ATOM   4244 H HB3  . LYS   B 1 63  ? -2.39338  5.24499   15.53041  1.000 19.99995 ? 541 LYS   A HB3  1 
ATOM   4245 H HG2  . LYS   B 1 63  ? -2.15404  6.45106   13.53444  1.000 22.82843 ? 541 LYS   A HG2  1 
ATOM   4246 H HG3  . LYS   B 1 63  ? -1.30669  5.25820   12.91436  1.000 22.82843 ? 541 LYS   A HG3  1 
ATOM   4247 H HD2  . LYS   B 1 63  ? -3.24690  3.86897   13.13071  1.000 23.14596 ? 541 LYS   A HD2  1 
ATOM   4248 H HD3  . LYS   B 1 63  ? -4.06688  5.16701   13.54075  1.000 23.14596 ? 541 LYS   A HD3  1 
ATOM   4249 H HE2  . LYS   B 1 63  ? -2.80661  4.82413   11.04449  1.000 32.97304 ? 541 LYS   A HE2  1 
ATOM   4250 H HE3  . LYS   B 1 63  ? -4.37203  4.68468   11.27992  1.000 32.97304 ? 541 LYS   A HE3  1 
ATOM   4251 H HZ1  . LYS   B 1 63  ? -2.99754  7.04053   11.54503  1.000 36.19453 ? 541 LYS   A HZ1  1 
ATOM   4252 H HZ2  . LYS   B 1 63  ? -3.88049  6.73960   10.43681  1.000 36.19453 ? 541 LYS   A HZ2  1 
ATOM   4253 H HZ3  . LYS   B 1 63  ? -4.42328  6.91511   11.76831  1.000 36.19453 ? 541 LYS   A HZ3  1 
ATOM   4254 N N    . ARG   B 1 64  ? -1.16581  7.81023   16.28357  1.000 15.51523 ? 542 ARG   A N    1 
ATOM   4255 C CA   . ARG   B 1 64  ? -1.24859  9.27338   16.28400  1.000 17.90369 ? 542 ARG   A CA   1 
ATOM   4256 C C    . ARG   B 1 64  ? 0.13058   9.89806   16.42214  1.000 17.90458 ? 542 ARG   A C    1 
ATOM   4257 O O    . ARG   B 1 64  ? 0.44785   10.88320  15.75639  1.000 19.50784 ? 542 ARG   A O    1 
ATOM   4258 C CB   . ARG   B 1 64  ? -2.16215  9.74927   17.41405  1.000 21.17597 ? 542 ARG   A CB   1 
ATOM   4259 C CG   . ARG   B 1 64  ? -3.36647  10.53461  16.96272  1.000 42.26494 ? 542 ARG   A CG   1 
ATOM   4260 C CD   . ARG   B 1 64  ? -4.63076  9.97877   17.62070  1.000 46.83318 ? 542 ARG   A CD   1 
ATOM   4261 N NE   . ARG   B 1 64  ? -4.52585  9.99804   19.07768  1.000 50.66572 ? 542 ARG   A NE   1 
ATOM   4262 C CZ   . ARG   B 1 64  ? -5.18028  9.17472   19.88683  1.000 49.70206 ? 542 ARG   A CZ   1 
ATOM   4263 N NH1  . ARG   B 1 64  ? -5.96784  8.21934   19.41500  1.000 40.92609 ? 542 ARG   A NH1  1 
ATOM   4264 N NH2  . ARG   B 1 64  ? -5.02333  9.29871   21.20092  1.000 51.82989 ? 542 ARG   A NH2  1 
ATOM   4265 H H    . ARG   B 1 64  ? -1.61429  7.42475   16.90796  1.000 18.57229 ? 542 ARG   A H    1 
ATOM   4266 H HA   . ARG   B 1 64  ? -1.63345  9.56440   15.44252  1.000 21.43844 ? 542 ARG   A HA   1 
ATOM   4267 H HB2  . ARG   B 1 64  ? -2.48447  8.97248   17.89738  1.000 25.36518 ? 542 ARG   A HB2  1 
ATOM   4268 H HB3  . ARG   B 1 64  ? -1.64752  10.31893  18.00697  1.000 25.36518 ? 542 ARG   A HB3  1 
ATOM   4269 H HG2  . ARG   B 1 64  ? -3.26533  11.46455  17.21939  1.000 50.67194 ? 542 ARG   A HG2  1 
ATOM   4270 H HG3  . ARG   B 1 64  ? -3.46039  10.46454  15.99982  1.000 50.67194 ? 542 ARG   A HG3  1 
ATOM   4271 H HD2  . ARG   B 1 64  ? -5.39259  10.52062  17.36206  1.000 56.15383 ? 542 ARG   A HD2  1 
ATOM   4272 H HD3  . ARG   B 1 64  ? -4.76442  9.06113   17.33614  1.000 56.15383 ? 542 ARG   A HD3  1 
ATOM   4273 H HE   . ARG   B 1 64  ? -4.00519  10.58197  19.43483  1.000 60.75288 ? 542 ARG   A HE   1 
ATOM   4274 H HH11 . ARG   B 1 64  ? -6.06427  8.12176   18.56601  1.000 49.06532 ? 542 ARG   A HH11 1 
ATOM   4275 H HH12 . ARG   B 1 64  ? -6.38259  7.69683   19.95774  1.000 49.06532 ? 542 ARG   A HH12 1 
ATOM   4276 H HH21 . ARG   B 1 64  ? -4.50308  9.90651   21.51638  1.000 62.14989 ? 542 ARG   A HH21 1 
ATOM   4277 H HH22 . ARG   B 1 64  ? -5.44203  8.77113   21.73566  1.000 62.14989 ? 542 ARG   A HH22 1 
ATOM   4278 N N    . GLN   B 1 65  ? 0.96654   9.33195   17.27793  1.000 17.07719 ? 543 GLN   A N    1 
ATOM   4279 C CA   . GLN   B 1 65  ? 2.31883   9.84248   17.45096  1.000 18.36173 ? 543 GLN   A CA   1 
ATOM   4280 C C    . GLN   B 1 65  ? 3.13697   9.67760   16.18283  1.000 19.16794 ? 543 GLN   A C    1 
ATOM   4281 O O    . GLN   B 1 65  ? 3.85891   10.59922  15.78019  1.000 20.05065 ? 543 GLN   A O    1 
ATOM   4282 C CB   . GLN   B 1 65  ? 2.98935   9.11316   18.60858  1.000 17.23576 ? 543 GLN   A CB   1 
ATOM   4283 C CG   . GLN   B 1 65  ? 2.31502   9.35294   19.97546  1.000 18.31693 ? 543 GLN   A CG   1 
ATOM   4284 C CD   . GLN   B 1 65  ? 2.93844   8.59424   21.08775  1.000 18.56520 ? 543 GLN   A CD   1 
ATOM   4285 O OE1  . GLN   B 1 65  ? 3.82059   7.75834   20.87887  1.000 20.26437 ? 543 GLN   A OE1  1 
ATOM   4286 N NE2  . GLN   B 1 65  ? 2.48027   8.84002   22.27783  1.000 16.89038 ? 543 GLN   A NE2  1 
ATOM   4287 H H    . GLN   B 1 65  ? 0.77851   8.65258   17.77057  1.000 20.44664 ? 543 GLN   A H    1 
ATOM   4288 H HA   . GLN   B 1 65  ? 2.27679   10.78887  17.65948  1.000 21.98810 ? 543 GLN   A HA   1 
ATOM   4289 H HB2  . GLN   B 1 65  ? 2.96573   8.15986   18.43093  1.000 20.63693 ? 543 GLN   A HB2  1 
ATOM   4290 H HB3  . GLN   B 1 65  ? 3.90860   9.41543   18.67582  1.000 20.63693 ? 543 GLN   A HB3  1 
ATOM   4291 H HG2  . GLN   B 1 65  ? 2.37323   10.29677  20.19156  1.000 21.93433 ? 543 GLN   A HG2  1 
ATOM   4292 H HG3  . GLN   B 1 65  ? 1.38526   9.08268   19.91715  1.000 21.93433 ? 543 GLN   A HG3  1 
ATOM   4293 H HE21 . GLN   B 1 65  ? 1.85027   9.41540   22.38569  1.000 20.22247 ? 543 GLN   A HE21 1 
ATOM   4294 H HE22 . GLN   B 1 65  ? 2.80687   8.42740   22.95803  1.000 20.22247 ? 543 GLN   A HE22 1 
ATOM   4295 N N    . MET   B 1 66  ? 3.03955   8.50734   15.53769  1.000 17.69779 ? 544 MET   A N    1 
ATOM   4296 C CA   . MET   B 1 66  ? 3.82032   8.27310   14.33214  1.000 17.06778 ? 544 MET   A CA   1 
ATOM   4297 C C    . MET   B 1 66  ? 3.35285   9.17386   13.19501  1.000 19.28487 ? 544 MET   A C    1 
ATOM   4298 O O    . MET   B 1 66  ? 4.17419   9.63700   12.39469  1.000 20.50839 ? 544 MET   A O    1 
ATOM   4299 C CB   . MET   B 1 66  ? 3.74923   6.78954   13.92962  1.000 16.57053 ? 544 MET   A CB   1 
ATOM   4300 C CG   . MET   B 1 66  ? 4.80451   6.40385   12.88890  1.000 18.61443 ? 544 MET   A CG   1 
ATOM   4301 S SD   . MET   B 1 66  ? 4.90040   4.60968   12.51778  1.000 17.78369 ? 544 MET   A SD   1 
ATOM   4302 C CE   . MET   B 1 66  ? 5.40147   3.99581   14.09672  1.000 16.07092 ? 544 MET   A CE   1 
ATOM   4303 H H    . MET   B 1 66  ? 2.53804   7.85094   15.77690  1.000 21.19136 ? 544 MET   A H    1 
ATOM   4304 H HA   . MET   B 1 66  ? 4.75058   8.47268   14.52103  1.000 20.43535 ? 544 MET   A HA   1 
ATOM   4305 H HB2  . MET   B 1 66  ? 3.89104   6.24199   14.71765  1.000 19.83865 ? 544 MET   A HB2  1 
ATOM   4306 H HB3  . MET   B 1 66  ? 2.87468   6.60700   13.55180  1.000 19.83865 ? 544 MET   A HB3  1 
ATOM   4307 H HG2  . MET   B 1 66  ? 4.60059   6.86238   12.05881  1.000 22.29133 ? 544 MET   A HG2  1 
ATOM   4308 H HG3  . MET   B 1 66  ? 5.67493   6.68052   13.21558  1.000 22.29133 ? 544 MET   A HG3  1 
ATOM   4309 H HE1  . MET   B 1 66  ? 5.61004   3.05187   14.01688  1.000 19.23911 ? 544 MET   A HE1  1 
ATOM   4310 H HE2  . MET   B 1 66  ? 6.18620   4.48422   14.39092  1.000 19.23911 ? 544 MET   A HE2  1 
ATOM   4311 H HE3  . MET   B 1 66  ? 4.67689   4.12213   14.72912  1.000 19.23911 ? 544 MET   A HE3  1 
ATOM   4312 N N    . ASP   B 1 67  ? 2.04077   9.43459   13.11297  1.000 19.29919 ? 545 ASP   A N    1 
ATOM   4313 C CA   . ASP   B 1 67  ? 1.54038   10.33768  12.08474  1.000 20.97356 ? 545 ASP   A CA   1 
ATOM   4314 C C    . ASP   B 1 67  ? 2.10348   11.74955  12.28876  1.000 22.84328 ? 545 ASP   A C    1 
ATOM   4315 O O    . ASP   B 1 67  ? 2.41120   12.44479  11.31583  1.000 24.40550 ? 545 ASP   A O    1 
ATOM   4316 C CB   . ASP   B 1 67  ? 0.00895   10.35123  12.08644  1.000 22.82437 ? 545 ASP   A CB   1 
ATOM   4317 C CG   . ASP   B 1 67  ? -0.60472  9.03467   11.60548  1.000 27.80477 ? 545 ASP   A CG   1 
ATOM   4318 O OD1  . ASP   B 1 67  ? 0.07771   8.21742   10.94485  1.000 24.95074 ? 545 ASP   A OD1  1 
ATOM   4319 O OD2  . ASP   B 1 67  ? -1.79895  8.78082   11.86842  1.000 23.81060 ? 545 ASP   A OD2  1 
ATOM   4320 H H    . ASP   B 1 67  ? 1.43777   9.10645   13.63096  1.000 23.11304 ? 545 ASP   A H    1 
ATOM   4321 H HA   . ASP   B 1 67  ? 1.82440   10.01906  11.21370  1.000 25.12229 ? 545 ASP   A HA   1 
ATOM   4322 H HB2  . ASP   B 1 67  ? -0.30323  10.51316  12.99044  1.000 27.34326 ? 545 ASP   A HB2  1 
ATOM   4323 H HB3  . ASP   B 1 67  ? -0.30007  11.05715  11.49730  1.000 27.34326 ? 545 ASP   A HB3  1 
ATOM   4324 N N    . ILE   B 1 68  ? 2.27055   12.17313  13.55325  1.000 21.28620 ? 546 ILE   A N    1 
ATOM   4325 C CA   . ILE   B 1 68  ? 2.89808   13.46817  13.83905  1.000 22.68106 ? 546 ILE   A CA   1 
ATOM   4326 C C    . ILE   B 1 68  ? 4.38977   13.43918  13.50591  1.000 23.39418 ? 546 ILE   A C    1 
ATOM   4327 O O    . ILE   B 1 68  ? 4.90696   14.32513  12.80840  1.000 24.60454 ? 546 ILE   A O    1 
ATOM   4328 C CB   . ILE   B 1 68  ? 2.67368   13.86126  15.31166  1.000 20.26178 ? 546 ILE   A CB   1 
ATOM   4329 C CG1  . ILE   B 1 68  ? 1.19606   14.14413  15.57100  1.000 24.61227 ? 546 ILE   A CG1  1 
ATOM   4330 C CG2  . ILE   B 1 68  ? 3.57356   15.01900  15.72211  1.000 21.96154 ? 546 ILE   A CG2  1 
ATOM   4331 C CD1  . ILE   B 1 68  ? 0.84613   14.21119  17.04067  1.000 24.04802 ? 546 ILE   A CD1  1 
ATOM   4332 H H    . ILE   B 1 68  ? 2.03149   11.73337  14.25258  1.000 25.49745 ? 546 ILE   A H    1 
ATOM   4333 H HA   . ILE   B 1 68  ? 2.47675   14.13342  13.27263  1.000 27.17129 ? 546 ILE   A HA   1 
ATOM   4334 H HB   . ILE   B 1 68  ? 2.92468   13.10898  15.87021  1.000 24.26815 ? 546 ILE   A HB   1 
ATOM   4335 H HG12 . ILE   B 1 68  ? 0.96555   14.99724  15.17104  1.000 29.48874 ? 546 ILE   A HG12 1 
ATOM   4336 H HG13 . ILE   B 1 68  ? 0.66677   13.43643  15.17111  1.000 29.48874 ? 546 ILE   A HG13 1 
ATOM   4337 H HG21 . ILE   B 1 68  ? 3.22421   15.41793  16.53434  1.000 26.30786 ? 546 ILE   A HG21 1 
ATOM   4338 H HG22 . ILE   B 1 68  ? 4.46987   14.68244  15.87790  1.000 26.30786 ? 546 ILE   A HG22 1 
ATOM   4339 H HG23 . ILE   B 1 68  ? 3.58650   15.67694  15.00948  1.000 26.30786 ? 546 ILE   A HG23 1 
ATOM   4340 H HD11 . ILE   B 1 68  ? -0.11920  14.21192  17.13574  1.000 28.81164 ? 546 ILE   A HD11 1 
ATOM   4341 H HD12 . ILE   B 1 68  ? 1.22221   13.43841  17.49042  1.000 28.81164 ? 546 ILE   A HD12 1 
ATOM   4342 H HD13 . ILE   B 1 68  ? 1.21615   15.02524  17.41657  1.000 28.81164 ? 546 ILE   A HD13 1 
ATOM   4343 N N    A LYS   B 1 69  ? 5.10324   12.43501  14.02187  0.562 23.48124 ? 547 LYS   A N    1 
ATOM   4344 N N    B LYS   B 1 69  ? 5.10196   12.42567  14.00610  0.438 23.45310 ? 547 LYS   A N    1 
ATOM   4345 C CA   A LYS   B 1 69  ? 6.54491   12.33661  13.81525  0.562 23.85154 ? 547 LYS   A CA   1 
ATOM   4346 C CA   B LYS   B 1 69  ? 6.54617   12.35646  13.81130  0.438 23.92024 ? 547 LYS   A CA   1 
ATOM   4347 C C    A LYS   B 1 69  ? 6.89780   12.35708  12.33430  0.562 26.05149 ? 547 LYS   A C    1 
ATOM   4348 C C    B LYS   B 1 69  ? 6.90731   12.35681  12.33119  0.438 26.01762 ? 547 LYS   A C    1 
ATOM   4349 O O    A LYS   B 1 69  ? 7.78593   13.10499  11.90474  0.562 26.92630 ? 547 LYS   A O    1 
ATOM   4350 O O    B LYS   B 1 69  ? 7.80099   13.09486  11.89679  0.438 26.89986 ? 547 LYS   A O    1 
ATOM   4351 C CB   A LYS   B 1 69  ? 7.06878   11.05616  14.48134  0.562 23.82614 ? 547 LYS   A CB   1 
ATOM   4352 C CB   B LYS   B 1 69  ? 7.10915   11.10541  14.49362  0.438 23.88514 ? 547 LYS   A CB   1 
ATOM   4353 C CG   A LYS   B 1 69  ? 8.45059   10.59153  14.03843  0.562 25.76337 ? 547 LYS   A CG   1 
ATOM   4354 C CG   B LYS   B 1 69  ? 8.61111   10.92665  14.31992  0.438 25.81665 ? 547 LYS   A CG   1 
ATOM   4355 C CD   A LYS   B 1 69  ? 8.65336   9.10067   14.39433  0.562 27.09507 ? 547 LYS   A CD   1 
ATOM   4356 C CD   B LYS   B 1 69  ? 9.10974   9.63984   14.98024  0.438 27.89557 ? 547 LYS   A CD   1 
ATOM   4357 C CE   A LYS   B 1 69  ? 9.79048   8.45512   13.58993  0.562 28.61018 ? 547 LYS   A CE   1 
ATOM   4358 C CE   B LYS   B 1 69  ? 9.50056   8.56634   13.95150  0.438 28.39093 ? 547 LYS   A CE   1 
ATOM   4359 N NZ   A LYS   B 1 69  ? 11.14673  8.60009   14.22036  0.562 25.16949 ? 547 LYS   A NZ   1 
ATOM   4360 N NZ   B LYS   B 1 69  ? 8.35211   7.96715   13.26812  0.438 22.63421 ? 547 LYS   A NZ   1 
ATOM   4361 H H    A LYS   B 1 69  ? 4.77430   11.79741  14.49608  0.562 28.13150 ? 547 LYS   A H    1 
ATOM   4362 H H    B LYS   B 1 69  ? 4.77346   11.77187  14.45803  0.438 28.09774 ? 547 LYS   A H    1 
ATOM   4363 H HA   A LYS   B 1 69  ? 6.97632   13.10023  14.22958  0.562 28.57586 ? 547 LYS   A HA   1 
ATOM   4364 H HA   B LYS   B 1 69  ? 6.94853   13.13786  14.22168  0.438 28.65830 ? 547 LYS   A HA   1 
ATOM   4365 H HB2  A LYS   B 1 69  ? 7.11032   11.20747  15.43856  0.562 28.54539 ? 547 LYS   A HB2  1 
ATOM   4366 H HB2  B LYS   B 1 69  ? 6.92690   11.16165  15.44468  0.438 28.61619 ? 547 LYS   A HB2  1 
ATOM   4367 H HB3  A LYS   B 1 69  ? 6.44809   10.33685  14.28579  0.562 28.54539 ? 547 LYS   A HB3  1 
ATOM   4368 H HB3  B LYS   B 1 69  ? 6.67381   10.32419  14.11802  0.438 28.61619 ? 547 LYS   A HB3  1 
ATOM   4369 H HG2  A LYS   B 1 69  ? 8.53725   10.69563  13.07793  0.562 30.87005 ? 547 LYS   A HG2  1 
ATOM   4370 H HG2  B LYS   B 1 69  ? 8.82121   10.88366  13.37393  0.438 30.93399 ? 547 LYS   A HG2  1 
ATOM   4371 H HG3  A LYS   B 1 69  ? 9.13094   11.11382  14.49147  0.562 30.87005 ? 547 LYS   A HG3  1 
ATOM   4372 H HG3  B LYS   B 1 69  ? 9.07215   11.67595  14.72844  0.438 30.93399 ? 547 LYS   A HG3  1 
ATOM   4373 H HD2  A LYS   B 1 69  ? 8.87130   9.02582   15.33656  0.562 32.46810 ? 547 LYS   A HD2  1 
ATOM   4374 H HD2  B LYS   B 1 69  ? 9.89198   9.84081   15.51747  0.438 33.42870 ? 547 LYS   A HD2  1 
ATOM   4375 H HD3  A LYS   B 1 69  ? 7.83606   8.61447   14.20322  0.562 32.46810 ? 547 LYS   A HD3  1 
ATOM   4376 H HD3  B LYS   B 1 69  ? 8.40629   9.27726   15.54112  0.438 33.42870 ? 547 LYS   A HD3  1 
ATOM   4377 H HE2  A LYS   B 1 69  ? 9.60816   7.50672   13.49942  0.562 34.28623 ? 547 LYS   A HE2  1 
ATOM   4378 H HE2  B LYS   B 1 69  ? 10.06913  8.97035   13.27741  0.438 34.02313 ? 547 LYS   A HE2  1 
ATOM   4379 H HE3  A LYS   B 1 69  ? 9.82727   8.87093   12.71435  0.562 34.28623 ? 547 LYS   A HE3  1 
ATOM   4380 H HE3  B LYS   B 1 69  ? 9.97893   7.85561   14.40640  0.438 34.02313 ? 547 LYS   A HE3  1 
ATOM   4381 H HZ1  A LYS   B 1 69  ? 11.15244  8.21423   15.02235  0.562 30.15740 ? 547 LYS   A HZ1  1 
ATOM   4382 H HZ1  B LYS   B 1 69  ? 8.63204   7.38669   12.65428  0.438 27.11507 ? 547 LYS   A HZ1  1 
ATOM   4383 H HZ2  A LYS   B 1 69  ? 11.76320  8.21226   13.70884  0.562 30.15740 ? 547 LYS   A HZ2  1 
ATOM   4384 H HZ2  B LYS   B 1 69  ? 7.83704   7.54060   13.85536  0.438 27.11507 ? 547 LYS   A HZ2  1 
ATOM   4385 H HZ3  A LYS   B 1 69  ? 11.34879  9.46188   14.31303  0.562 30.15740 ? 547 LYS   A HZ3  1 
ATOM   4386 H HZ3  B LYS   B 1 69  ? 7.87118   8.60055   12.86862  0.438 27.11507 ? 547 LYS   A HZ3  1 
ATOM   4387 N N    . ASN   B 1 70  ? 6.23404   11.52913  11.54079  1.000 23.80379 ? 548 ASN   A N    1 
ATOM   4388 C CA   . ASN   B 1 70  ? 6.56888   11.38703  10.13223  1.000 26.04931 ? 548 ASN   A CA   1 
ATOM   4389 C C    . ASN   B 1 70  ? 5.90097   12.43916  9.24939   1.000 32.83210 ? 548 ASN   A C    1 
ATOM   4390 O O    . ASN   B 1 70  ? 6.13740   12.44884  8.03809   1.000 42.87989 ? 548 ASN   A O    1 
ATOM   4391 C CB   . ASN   B 1 70  ? 6.19170   9.98843   9.65313   1.000 24.70664 ? 548 ASN   A CB   1 
ATOM   4392 C CG   . ASN   B 1 70  ? 7.03410   8.90627   10.31799  1.000 22.36932 ? 548 ASN   A CG   1 
ATOM   4393 O OD1  . ASN   B 1 70  ? 8.06086   9.21087   10.93564  1.000 22.87118 ? 548 ASN   A OD1  1 
ATOM   4394 N ND2  . ASN   B 1 70  ? 6.60023   7.65262   10.21307  1.000 21.69154 ? 548 ASN   A ND2  1 
ATOM   4395 H H    A ASN   B 1 70  ? 5.57924   11.03379  11.79667  0.562 28.51856 ? 548 ASN   A H    1 
ATOM   4396 H H    B ASN   B 1 70  ? 5.57703   11.03775  11.79864  0.438 28.51856 ? 548 ASN   A H    1 
ATOM   4397 H HA   . ASN   B 1 70  ? 7.52766   11.48999  10.02714  1.000 31.21319 ? 548 ASN   A HA   1 
ATOM   4398 H HB2  . ASN   B 1 70  ? 5.26034   9.81964   9.86519   1.000 29.60198 ? 548 ASN   A HB2  1 
ATOM   4399 H HB3  . ASN   B 1 70  ? 6.32912   9.93241   8.69455   1.000 29.60198 ? 548 ASN   A HB3  1 
ATOM   4400 H HD21 . ASN   B 1 70  ? 7.04598   7.01172   10.57383  1.000 25.98387 ? 548 ASN   A HD21 1 
ATOM   4401 H HD22 . ASN   B 1 70  ? 5.87409   7.48335   9.78450   1.000 25.98387 ? 548 ASN   A HD22 1 
ATOM   4402 N N    . ASP   B 1 71  ? 5.08702   13.32784  9.81156   1.000 35.53136 ? 549 ASP   A N    1 
ATOM   4403 C CA   . ASP   B 1 71  ? 4.45662   14.41735  9.05933   1.000 42.74113 ? 549 ASP   A CA   1 
ATOM   4404 C C    . ASP   B 1 71  ? 3.54590   13.90204  7.95033   1.000 48.18397 ? 549 ASP   A C    1 
ATOM   4405 O O    . ASP   B 1 71  ? 3.17955   14.65083  7.03939   1.000 50.15075 ? 549 ASP   A O    1 
ATOM   4406 C CB   . ASP   B 1 71  ? 5.51196   15.36900  8.46521   1.000 45.49045 ? 549 ASP   A CB   1 
ATOM   4407 H H    . ASP   B 1 71  ? 4.87819   13.32273  10.64580  1.000 42.59165 ? 549 ASP   A H    1 
ATOM   4408 H HA   . ASP   B 1 71  ? 3.90654   14.92425  9.67688   1.000 51.24338 ? 549 ASP   A HA   1 
ATOM   4409 N N    . HIS   B 1 72  ? 3.18329   12.62594  8.00638   1.000 48.28452 ? 550 HIS   A N    1 
ATOM   4410 C CA   . HIS   B 1 72  ? 2.32149   12.00827  7.00793   1.000 51.13705 ? 550 HIS   A CA   1 
ATOM   4411 C C    . HIS   B 1 72  ? 1.52872   10.91922  7.70509   1.000 50.54058 ? 550 HIS   A C    1 
ATOM   4412 O O    . HIS   B 1 72  ? 1.82129   10.55185  8.84874   1.000 50.14719 ? 550 HIS   A O    1 
ATOM   4413 C CB   . HIS   B 1 72  ? 3.11970   11.43112  5.83268   1.000 47.11621 ? 550 HIS   A CB   1 
ATOM   4414 H H    . HIS   B 1 72  ? 3.42919   12.08441  8.62757   1.000 57.89544 ? 550 HIS   A H    1 
ATOM   4415 H HA   . HIS   B 1 72  ? 1.71427   12.67312  6.64715   1.000 61.31847 ? 550 HIS   A HA   1 
ATOM   4416 N N    . LYS   B 1 73  ? 0.53184   10.38584  7.00017   1.000 56.63925 ? 551 LYS   A N    1 
ATOM   4417 C CA   . LYS   B 1 73  ? -0.40221  9.42240   7.57656   1.000 49.48427 ? 551 LYS   A CA   1 
ATOM   4418 C C    . LYS   B 1 73  ? -0.46141  8.15268   6.73735   1.000 48.44889 ? 551 LYS   A C    1 
ATOM   4419 O O    . LYS   B 1 73  ? -1.52035  7.52964   6.59458   1.000 62.38130 ? 551 LYS   A O    1 
ATOM   4420 C CB   . LYS   B 1 73  ? -1.79685  10.03402  7.72345   1.000 44.46739 ? 551 LYS   A CB   1 
ATOM   4421 H H    . LYS   B 1 73  ? 0.37537   10.57004  6.17483   1.000 67.92112 ? 551 LYS   A H    1 
ATOM   4422 H HA   . LYS   B 1 73  ? -0.08080  9.17839   8.45864   1.000 59.33514 ? 551 LYS   A HA   1 
ATOM   4423 N N    . ASN   B 1 74  ? 0.67423   7.74394   6.17168   1.000 38.15161 ? 552 ASN   A N    1 
ATOM   4424 C CA   . ASN   B 1 74  ? 0.72478   6.47490   5.45219   1.000 38.00260 ? 552 ASN   A CA   1 
ATOM   4425 C C    . ASN   B 1 74  ? 1.60354   5.47764   6.20822   1.000 26.38961 ? 552 ASN   A C    1 
ATOM   4426 O O    . ASN   B 1 74  ? 2.48012   4.83843   5.61842   1.000 31.68295 ? 552 ASN   A O    1 
ATOM   4427 C CB   . ASN   B 1 74  ? 1.25999   6.68905   4.03737   1.000 38.87860 ? 552 ASN   A CB   1 
ATOM   4428 H H    . ASN   B 1 74  ? 1.41668   8.17753   6.19086   1.000 45.73594 ? 552 ASN   A H    1 
ATOM   4429 H HA   . ASN   B 1 74  ? -0.16932  6.10552   5.38120   1.000 45.55714 ? 552 ASN   A HA   1 
ATOM   4430 N N    . ASN   B 1 75  ? 1.38925   5.36210   7.52932   1.000 24.86641 ? 553 ASN   A N    1 
ATOM   4431 C CA   . ASN   B 1 75  ? 2.29346   4.60509   8.37996   1.000 20.46195 ? 553 ASN   A CA   1 
ATOM   4432 C C    . ASN   B 1 75  ? 1.81512   3.19624   8.68219   1.000 18.11937 ? 553 ASN   A C    1 
ATOM   4433 O O    . ASN   B 1 75  ? 2.54431   2.44018   9.32697   1.000 16.89884 ? 553 ASN   A O    1 
ATOM   4434 C CB   . ASN   B 1 75  ? 2.50256   5.33573   9.69401   1.000 19.29586 ? 553 ASN   A CB   1 
ATOM   4435 C CG   . ASN   B 1 75  ? 3.23482   6.64679   9.51827   1.000 23.04517 ? 553 ASN   A CG   1 
ATOM   4436 O OD1  . ASN   B 1 75  ? 4.31282   6.67782   8.95567   1.000 20.78555 ? 553 ASN   A OD1  1 
ATOM   4437 N ND2  . ASN   B 1 75  ? 2.60616   7.74195   9.96325   1.000 24.65864 ? 553 ASN   A ND2  1 
ATOM   4438 H H    . ASN   B 1 75  ? 0.72539   5.71623   7.94583   1.000 29.79370 ? 553 ASN   A H    1 
ATOM   4439 H HA   . ASN   B 1 75  ? 3.14300   4.53645   7.91685   1.000 24.50835 ? 553 ASN   A HA   1 
ATOM   4440 H HB2  . ASN   B 1 75  ? 1.63861   5.52476   10.09246  1.000 23.10904 ? 553 ASN   A HB2  1 
ATOM   4441 H HB3  . ASN   B 1 75  ? 3.02650   4.77581   10.28805  1.000 23.10904 ? 553 ASN   A HB3  1 
ATOM   4442 H HD21 . ASN   B 1 75  ? 2.97958   8.51290   9.88719   1.000 29.54438 ? 553 ASN   A HD21 1 
ATOM   4443 H HD22 . ASN   B 1 75  ? 1.82893   7.67444   10.32514  1.000 29.54438 ? 553 ASN   A HD22 1 
ATOM   4444 N N    . GLU   B 1 76  ? 0.61026   2.84578   8.25995   1.000 19.42235 ? 554 GLU   A N    1 
ATOM   4445 C CA   . GLU   B 1 76  ? -0.04607  1.59487   8.62124   1.000 19.39835 ? 554 GLU   A CA   1 
ATOM   4446 C C    . GLU   B 1 76  ? -0.12563  0.64589   7.42552   1.000 20.39395 ? 554 GLU   A C    1 
ATOM   4447 O O    . GLU   B 1 76  ? -0.37112  1.07640   6.29611   1.000 20.62060 ? 554 GLU   A O    1 
ATOM   4448 C CB   . GLU   B 1 76  ? -1.46503  1.91549   9.11429   1.000 24.11298 ? 554 GLU   A CB   1 
ATOM   4449 C CG   . GLU   B 1 76  ? -2.09683  0.90984   9.98732   1.000 27.30467 ? 554 GLU   A CG   1 
ATOM   4450 C CD   . GLU   B 1 76  ? -3.34826  1.46776   10.66422  1.000 26.94058 ? 554 GLU   A CD   1 
ATOM   4451 O OE1  . GLU   B 1 76  ? -4.01918  2.32254   10.04618  1.000 29.15354 ? 554 GLU   A OE1  1 
ATOM   4452 O OE2  . GLU   B 1 76  ? -3.63703  1.05528   11.78858  1.000 23.72859 ? 554 GLU   A OE2  1 
ATOM   4453 H H    . GLU   B 1 76  ? 0.13076   3.33581   7.74076   1.000 23.26083 ? 554 GLU   A H    1 
ATOM   4454 H HA   . GLU   B 1 76  ? 0.46228   1.13750   9.30921   1.000 23.23203 ? 554 GLU   A HA   1 
ATOM   4455 H HB2  . GLU   B 1 76  ? -1.43020  2.74577   9.61463   1.000 28.88959 ? 554 GLU   A HB2  1 
ATOM   4456 H HB3  . GLU   B 1 76  ? -2.03776  2.01952   8.33837   1.000 28.88959 ? 554 GLU   A HB3  1 
ATOM   4457 H HG2  . GLU   B 1 76  ? -2.35377  0.13952   9.45676   1.000 32.71962 ? 554 GLU   A HG2  1 
ATOM   4458 H HG3  . GLU   B 1 76  ? -1.46915  0.64315   10.67710  1.000 32.71962 ? 554 GLU   A HG3  1 
ATOM   4459 N N    . ARG   B 1 77  ? 0.06282   -0.63567  7.69625   1.000 19.73723 ? 555 ARG   A N    1 
ATOM   4460 C CA   . ARG   B 1 77  ? -0.07760  -1.70096  6.71875   1.000 20.86090 ? 555 ARG   A CA   1 
ATOM   4461 C C    . ARG   B 1 77  ? -0.82029  -2.85967  7.36964   1.000 19.53396 ? 555 ARG   A C    1 
ATOM   4462 O O    . ARG   B 1 77  ? -0.71235  -3.08518  8.57965   1.000 18.75381 ? 555 ARG   A O    1 
ATOM   4463 C CB   . ARG   B 1 77  ? 1.28254   -2.23273  6.21680   1.000 21.57839 ? 555 ARG   A CB   1 
ATOM   4464 C CG   . ARG   B 1 77  ? 2.09032   -1.18126  5.40937   1.000 25.09175 ? 555 ARG   A CG   1 
ATOM   4465 C CD   . ARG   B 1 77  ? 3.46612   -1.75858  5.02253   1.000 20.26331 ? 555 ARG   A CD   1 
ATOM   4466 N NE   . ARG   B 1 77  ? 4.26440   -0.74810  4.34292   1.000 28.01922 ? 555 ARG   A NE   1 
ATOM   4467 C CZ   . ARG   B 1 77  ? 4.52528   -0.75318  3.04850   1.000 31.18186 ? 555 ARG   A CZ   1 
ATOM   4468 N NH1  . ARG   B 1 77  ? 4.10003   -1.72555  2.26744   1.000 27.86545 ? 555 ARG   A NH1  1 
ATOM   4469 N NH2  . ARG   B 1 77  ? 5.25635   0.22892   2.53164   1.000 40.66369 ? 555 ARG   A NH2  1 
ATOM   4470 H H    . ARG   B 1 77  ? 0.28281   -0.92697  8.47493   1.000 23.63869 ? 555 ARG   A H    1 
ATOM   4471 H HA   . ARG   B 1 77  ? -0.57585  -1.36000  5.95955   1.000 24.98709 ? 555 ARG   A HA   1 
ATOM   4472 H HB2  . ARG   B 1 77  ? 1.81763   -2.49735  6.98136   1.000 25.84808 ? 555 ARG   A HB2  1 
ATOM   4473 H HB3  . ARG   B 1 77  ? 1.12726   -2.99701  5.64003   1.000 25.84808 ? 555 ARG   A HB3  1 
ATOM   4474 H HG2  . ARG   B 1 77  ? 1.60987   -0.95174  4.59857   1.000 30.06412 ? 555 ARG   A HG2  1 
ATOM   4475 H HG3  . ARG   B 1 77  ? 2.22661   -0.38763  5.95017   1.000 30.06412 ? 555 ARG   A HG3  1 
ATOM   4476 H HD2  . ARG   B 1 77  ? 3.93762   -2.04035  5.82203   1.000 24.26998 ? 555 ARG   A HD2  1 
ATOM   4477 H HD3  . ARG   B 1 77  ? 3.34639   -2.51304  4.42474   1.000 24.26998 ? 555 ARG   A HD3  1 
ATOM   4478 H HE   . ARG   B 1 77  ? 4.58704   -0.10604  4.81543   1.000 33.57708 ? 555 ARG   A HE   1 
ATOM   4479 H HH11 . ARG   B 1 77  ? 3.64261   -2.37419  2.59854   1.000 33.39255 ? 555 ARG   A HH11 1 
ATOM   4480 H HH12 . ARG   B 1 77  ? 4.27992   -1.71152  1.42658   1.000 33.39255 ? 555 ARG   A HH12 1 
ATOM   4481 H HH21 . ARG   B 1 77  ? 5.55293   0.85694   3.03883   1.000 48.75045 ? 555 ARG   A HH21 1 
ATOM   4482 H HH22 . ARG   B 1 77  ? 5.43288   0.23644   1.68999   1.000 48.75045 ? 555 ARG   A HH22 1 
ATOM   4483 N N    . LEU   B 1 78  ? -1.54750  -3.62890  6.55256   1.000 17.28379 ? 556 LEU   A N    1 
ATOM   4484 C CA   . LEU   B 1 78  ? -2.23004  -4.82414  7.02424   1.000 17.00316 ? 556 LEU   A CA   1 
ATOM   4485 C C    . LEU   B 1 78  ? -1.37278  -6.03050  6.66049   1.000 18.24731 ? 556 LEU   A C    1 
ATOM   4486 O O    . LEU   B 1 78  ? -1.16571  -6.32707  5.47915   1.000 20.61736 ? 556 LEU   A O    1 
ATOM   4487 C CB   . LEU   B 1 78  ? -3.62047  -4.92305  6.39327   1.000 20.76973 ? 556 LEU   A CB   1 
ATOM   4488 C CG   . LEU   B 1 78  ? -4.67809  -5.69320  7.14963   1.000 28.36987 ? 556 LEU   A CG   1 
ATOM   4489 C CD1  . LEU   B 1 78  ? -4.95467  -5.08344  8.52011   1.000 26.91299 ? 556 LEU   A CD1  1 
ATOM   4490 C CD2  . LEU   B 1 78  ? -5.97054  -5.73960  6.32717   1.000 23.57965 ? 556 LEU   A CD2  1 
ATOM   4491 H H    . LEU   B 1 78  ? -1.65740  -3.47199  5.71417   1.000 20.69456 ? 556 LEU   A H    1 
ATOM   4492 H HA   . LEU   B 1 78  ? -2.32965  -4.79427  7.98865   1.000 20.35781 ? 556 LEU   A HA   1 
ATOM   4493 H HB2  . LEU   B 1 78  ? -3.95857  -4.02116  6.27844   1.000 24.87769 ? 556 LEU   A HB2  1 
ATOM   4494 H HB3  . LEU   B 1 78  ? -3.52390  -5.35364  5.52946   1.000 24.87769 ? 556 LEU   A HB3  1 
ATOM   4495 H HG   . LEU   B 1 78  ? -4.35395  -6.59560  7.29628   1.000 33.99786 ? 556 LEU   A HG   1 
ATOM   4496 H HD11 . LEU   B 1 78  ? -5.76298  -5.47750  8.88378   1.000 32.24960 ? 556 LEU   A HD11 1 
ATOM   4497 H HD12 . LEU   B 1 78  ? -4.20388  -5.26891  9.10562   1.000 32.24960 ? 556 LEU   A HD12 1 
ATOM   4498 H HD13 . LEU   B 1 78  ? -5.06894  -4.12519  8.42218   1.000 32.24960 ? 556 LEU   A HD13 1 
ATOM   4499 H HD21 . LEU   B 1 78  ? -6.59857  -6.33929  6.75942   1.000 28.24960 ? 556 LEU   A HD21 1 
ATOM   4500 H HD22 . LEU   B 1 78  ? -6.34602  -4.84655  6.27833   1.000 28.24960 ? 556 LEU   A HD22 1 
ATOM   4501 H HD23 . LEU   B 1 78  ? -5.76596  -6.06163  5.43535   1.000 28.24960 ? 556 LEU   A HD23 1 
ATOM   4502 N N    . LEU   B 1 79  ? -0.87292  -6.71953  7.66262   1.000 14.71286 ? 557 LEU   A N    1 
ATOM   4503 C CA   . LEU   B 1 79  ? 0.07739   -7.80242  7.46433   1.000 15.53255 ? 557 LEU   A CA   1 
ATOM   4504 C C    . LEU   B 1 79  ? -0.43688  -9.05827  8.16993   1.000 15.05560 ? 557 LEU   A C    1 
ATOM   4505 O O    . LEU   B 1 79  ? -1.45923  -9.04147  8.85487   1.000 14.95951 ? 557 LEU   A O    1 
ATOM   4506 C CB   . LEU   B 1 79  ? 1.46500   -7.41892  7.98257   1.000 15.33968 ? 557 LEU   A CB   1 
ATOM   4507 C CG   . LEU   B 1 79  ? 2.05158   -6.15912  7.36527   1.000 15.31888 ? 557 LEU   A CG   1 
ATOM   4508 C CD1  . LEU   B 1 79  ? 3.36188   -5.80504  8.07757   1.000 16.22095 ? 557 LEU   A CD1  1 
ATOM   4509 C CD2  . LEU   B 1 79  ? 2.29737   -6.34528  5.85987   1.000 15.90051 ? 557 LEU   A CD2  1 
ATOM   4510 H H    . LEU   B 1 79  ? -1.07068  -6.57877  8.48765   1.000 17.60945 ? 557 LEU   A H    1 
ATOM   4511 H HA   . LEU   B 1 79  ? 0.14607   -7.99275  6.51567   1.000 18.59307 ? 557 LEU   A HA   1 
ATOM   4512 H HB2  . LEU   B 1 79  ? 1.40613   -7.27503  8.94003   1.000 18.36163 ? 557 LEU   A HB2  1 
ATOM   4513 H HB3  . LEU   B 1 79  ? 2.07567   -8.14850  7.79366   1.000 18.36163 ? 557 LEU   A HB3  1 
ATOM   4514 H HG   . LEU   B 1 79  ? 1.42297   -5.42794  7.47075   1.000 18.33667 ? 557 LEU   A HG   1 
ATOM   4515 H HD11 . LEU   B 1 79  ? 3.73455   -5.00548  7.67417   1.000 19.41915 ? 557 LEU   A HD11 1 
ATOM   4516 H HD12 . LEU   B 1 79  ? 3.17801   -5.64679  9.01675   1.000 19.41915 ? 557 LEU   A HD12 1 
ATOM   4517 H HD13 . LEU   B 1 79  ? 3.98294   -6.54400  7.98204   1.000 19.41915 ? 557 LEU   A HD13 1 
ATOM   4518 H HD21 . LEU   B 1 79  ? 2.75006   -5.56006  5.51432   1.000 19.03463 ? 557 LEU   A HD21 1 
ATOM   4519 H HD22 . LEU   B 1 79  ? 2.84924   -7.13148  5.72483   1.000 19.03463 ? 557 LEU   A HD22 1 
ATOM   4520 H HD23 . LEU   B 1 79  ? 1.44435   -6.45907  5.41231   1.000 19.03463 ? 557 LEU   A HD23 1 
ATOM   4521 N N    . PHE   B 1 80  ? 0.30586   -10.15642 8.02508   1.000 14.27711 ? 558 PHE   A N    1 
ATOM   4522 C CA   . PHE   B 1 80  ? -0.08949  -11.43647 8.57153   1.000 14.10234 ? 558 PHE   A CA   1 
ATOM   4523 C C    . PHE   B 1 80  ? 0.94056   -11.92102 9.58162   1.000 15.34373 ? 558 PHE   A C    1 
ATOM   4524 O O    . PHE   B 1 80  ? 2.11758   -11.61047 9.48488   1.000 15.02509 ? 558 PHE   A O    1 
ATOM   4525 C CB   . PHE   B 1 80  ? -0.24537  -12.49727 7.45822   1.000 14.39505 ? 558 PHE   A CB   1 
ATOM   4526 C CG   . PHE   B 1 80  ? -1.30988  -12.15131 6.44836   1.000 17.01467 ? 558 PHE   A CG   1 
ATOM   4527 C CD1  . PHE   B 1 80  ? -2.64401  -12.44972 6.70667   1.000 18.69909 ? 558 PHE   A CD1  1 
ATOM   4528 C CD2  . PHE   B 1 80  ? -0.98437  -11.50369 5.27892   1.000 16.08703 ? 558 PHE   A CD2  1 
ATOM   4529 C CE1  . PHE   B 1 80  ? -3.62154  -12.12235 5.79403   1.000 16.85372 ? 558 PHE   A CE1  1 
ATOM   4530 C CE2  . PHE   B 1 80  ? -1.95520  -11.17083 4.34155   1.000 18.12228 ? 558 PHE   A CE2  1 
ATOM   4531 C CZ   . PHE   B 1 80  ? -3.28944  -11.46572 4.61412   1.000 17.89052 ? 558 PHE   A CZ   1 
ATOM   4532 H H    . PHE   B 1 80  ? 1.05588   -10.17653 7.60476   1.000 17.08655 ? 558 PHE   A H    1 
ATOM   4533 H HA   . PHE   B 1 80  ? -0.93966  -11.33520 9.02743   1.000 16.87682 ? 558 PHE   A HA   1 
ATOM   4534 H HB2  . PHE   B 1 80  ? 0.59741   -12.58174 6.98548   1.000 17.22807 ? 558 PHE   A HB2  1 
ATOM   4535 H HB3  . PHE   B 1 80  ? -0.48440  -13.34511 7.86432   1.000 17.22807 ? 558 PHE   A HB3  1 
ATOM   4536 H HD1  . PHE   B 1 80  ? -2.87709  -12.87319 7.50118   1.000 22.39292 ? 558 PHE   A HD1  1 
ATOM   4537 H HD2  . PHE   B 1 80  ? -0.09620  -11.28406 5.11214   1.000 19.25845 ? 558 PHE   A HD2  1 
ATOM   4538 H HE1  . PHE   B 1 80  ? -4.50853  -12.34151 5.96759   1.000 20.17848 ? 558 PHE   A HE1  1 
ATOM   4539 H HE2  . PHE   B 1 80  ? -1.71748  -10.75695 3.54337   1.000 21.70076 ? 558 PHE   A HE2  1 
ATOM   4540 H HZ   . PHE   B 1 80  ? -3.95430  -11.22469 4.01017   1.000 21.42264 ? 558 PHE   A HZ   1 
ATOM   4541 N N    . HIS   B 1 81  ? 0.47990   -12.69478 10.55139  1.000 14.55289 ? 559 HIS   A N    1 
ATOM   4542 C CA   . HIS   B 1 81  ? 1.36308   -13.30509 11.53236  1.000 15.42129 ? 559 HIS   A CA   1 
ATOM   4543 C C    . HIS   B 1 81  ? 0.83973   -14.69106 11.85494  1.000 15.78822 ? 559 HIS   A C    1 
ATOM   4544 O O    . HIS   B 1 81  ? -0.22211  -14.83085 12.46340  1.000 16.93453 ? 559 HIS   A O    1 
ATOM   4545 C CB   . HIS   B 1 81  ? 1.47262   -12.47304 12.79231  1.000 16.04855 ? 559 HIS   A CB   1 
ATOM   4546 C CG   . HIS   B 1 81  ? 2.42891   -13.06268 13.78094  1.000 15.78064 ? 559 HIS   A CG   1 
ATOM   4547 N ND1  . HIS   B 1 81  ? 3.77683   -12.75868 13.77263  1.000 16.04233 ? 559 HIS   A ND1  1 
ATOM   4548 C CD2  . HIS   B 1 81  ? 2.23978   -13.92399 14.80805  1.000 17.55285 ? 559 HIS   A CD2  1 
ATOM   4549 C CE1  . HIS   B 1 81  ? 4.38410   -13.41979 14.74086  1.000 20.08035 ? 559 HIS   A CE1  1 
ATOM   4550 N NE2  . HIS   B 1 81  ? 3.47573   -14.14372 15.38036  1.000 18.53057 ? 559 HIS   A NE2  1 
ATOM   4551 H H    . HIS   B 1 81  ? -0.35138  -12.88416 10.66418  1.000 17.41748 ? 559 HIS   A H    1 
ATOM   4552 H HA   . HIS   B 1 81  ? 2.24728   -13.38786 11.14218  1.000 18.45956 ? 559 HIS   A HA   1 
ATOM   4553 H HB2  . HIS   B 1 81  ? 1.78704   -11.58527 12.56018  1.000 19.21228 ? 559 HIS   A HB2  1 
ATOM   4554 H HB3  . HIS   B 1 81  ? 0.60012   -12.41667 13.21241  1.000 19.21228 ? 559 HIS   A HB3  1 
ATOM   4555 H HD1  . HIS   B 1 81  ? 4.16101   -12.22162 13.22167  1.000 19.20481 ? 559 HIS   A HD1  1 
ATOM   4556 H HD2  . HIS   B 1 81  ? 1.43107   -14.29650 15.07661  1.000 21.01743 ? 559 HIS   A HD2  1 
ATOM   4557 H HE1  . HIS   B 1 81  ? 5.29185   -13.38390 14.93988  1.000 24.05043 ? 559 HIS   A HE1  1 
ATOM   4558 N N    . GLY   B 1 82  ? 1.59747   -15.71002 11.47500  1.000 15.25052 ? 560 GLY   A N    1 
ATOM   4559 C CA   . GLY   B 1 82  ? 1.24920   -17.09763 11.84477  1.000 17.42830 ? 560 GLY   A CA   1 
ATOM   4560 C C    . GLY   B 1 82  ? 1.94163   -17.45299 13.14341  1.000 19.78722 ? 560 GLY   A C    1 
ATOM   4561 O O    . GLY   B 1 82  ? 3.08859   -17.10785 13.34376  1.000 18.66408 ? 560 GLY   A O    1 
ATOM   4562 H H    . GLY   B 1 82  ? 2.31474   -15.63675 11.00623  1.000 18.25463 ? 560 GLY   A H    1 
ATOM   4563 H HA2  . GLY   B 1 82  ? 0.28986   -17.18151 11.96106  1.000 20.86797 ? 560 GLY   A HA2  1 
ATOM   4564 H HA3  . GLY   B 1 82  ? 1.53799   -17.71069 11.15076  1.000 20.86797 ? 560 GLY   A HA3  1 
ATOM   4565 N N    . THR   B 1 83  ? 1.22730   -18.15653 14.02418  1.000 18.85881 ? 561 THR   A N    1 
ATOM   4566 C CA   . THR   B 1 83  ? 1.85887   -18.59628 15.26188  1.000 23.35456 ? 561 THR   A CA   1 
ATOM   4567 C C    . THR   B 1 83  ? 1.22308   -19.90017 15.71175  1.000 22.55178 ? 561 THR   A C    1 
ATOM   4568 O O    . THR   B 1 83  ? 0.27311   -20.39474 15.10200  1.000 20.49467 ? 561 THR   A O    1 
ATOM   4569 C CB   . THR   B 1 83  ? 1.76089   -17.49892 16.35388  1.000 23.93027 ? 561 THR   A CB   1 
ATOM   4570 O OG1  . THR   B 1 83  ? 2.58497   -17.85708 17.48802  1.000 24.09929 ? 561 THR   A OG1  1 
ATOM   4571 C CG2  . THR   B 1 83  ? 0.33809   -17.30560 16.79387  1.000 20.82944 ? 561 THR   A CG2  1 
ATOM   4572 H H    . THR   B 1 83  ? 0.40312   -18.38250 13.92798  1.000 22.58459 ? 561 THR   A H    1 
ATOM   4573 H HA   . THR   B 1 83  ? 2.79807   -18.77749 15.10073  1.000 27.97948 ? 561 THR   A HA   1 
ATOM   4574 H HB   . THR   B 1 83  ? 2.07541   -16.65678 15.98949  1.000 28.67034 ? 561 THR   A HB   1 
ATOM   4575 H HG1  . THR   B 1 83  ? 3.38759   -17.92532 17.24982  1.000 28.87317 ? 561 THR   A HG1  1 
ATOM   4576 H HG21 . THR   B 1 83  ? 0.26193   -16.49743 17.32486  1.000 24.94934 ? 561 THR   A HG21 1 
ATOM   4577 H HG22 . THR   B 1 83  ? -0.24116  -17.22928 16.01957  1.000 24.94934 ? 561 THR   A HG22 1 
ATOM   4578 H HG23 . THR   B 1 83  ? 0.05057   -18.06198 17.32878  1.000 24.94934 ? 561 THR   A HG23 1 
ATOM   4579 N N    . ASP   B 1 84  ? 1.77062   -20.46668 16.77812  1.000 22.76440 ? 562 ASP   A N    1 
ATOM   4580 C CA   . ASP   B 1 84  ? 1.25650   -21.73618 17.27253  1.000 23.50445 ? 562 ASP   A CA   1 
ATOM   4581 C C    . ASP   B 1 84  ? 0.05931   -21.51973 18.18875  1.000 23.23800 ? 562 ASP   A C    1 
ATOM   4582 O O    . ASP   B 1 84  ? -0.19191  -20.42408 18.71223  1.000 23.19836 ? 562 ASP   A O    1 
ATOM   4583 C CB   . ASP   B 1 84  ? 2.35705   -22.52530 18.00388  1.000 25.88370 ? 562 ASP   A CB   1 
ATOM   4584 C CG   . ASP   B 1 84  ? 2.97173   -21.77527 19.15412  1.000 30.38299 ? 562 ASP   A CG   1 
ATOM   4585 O OD1  . ASP   B 1 84  ? 2.58095   -20.64236 19.44401  1.000 27.30283 ? 562 ASP   A OD1  1 
ATOM   4586 O OD2  . ASP   B 1 84  ? 3.88903   -22.33510 19.78130  1.000 34.09152 ? 562 ASP   A OD2  1 
ATOM   4587 H H    . ASP   B 1 84  ? 2.42935   -20.14229 17.22584  1.000 27.27130 ? 562 ASP   A H    1 
ATOM   4588 H HA   . ASP   B 1 84  ? 0.95944   -22.27131 16.52001  1.000 28.15936 ? 562 ASP   A HA   1 
ATOM   4589 H HB2  . ASP   B 1 84  ? 1.97412   -23.34448 18.35488  1.000 31.01445 ? 562 ASP   A HB2  1 
ATOM   4590 H HB3  . ASP   B 1 84  ? 3.06448   -22.73321 17.37362  1.000 31.01445 ? 562 ASP   A HB3  1 
ATOM   4591 N N    . ALA   B 1 85  ? -0.71891  -22.57930 18.35304  1.000 23.65294 ? 563 ALA   A N    1 
ATOM   4592 C CA   . ALA   B 1 85  ? -1.93345  -22.49378 19.15253  1.000 27.27656 ? 563 ALA   A CA   1 
ATOM   4593 C C    . ALA   B 1 85  ? -1.64862  -22.06465 20.58428  1.000 24.31450 ? 563 ALA   A C    1 
ATOM   4594 O O    . ALA   B 1 85  ? -2.47214  -21.36932 21.19304  1.000 22.45957 ? 563 ALA   A O    1 
ATOM   4595 C CB   . ALA   B 1 85  ? -2.65555  -23.84825 19.14896  1.000 26.84855 ? 563 ALA   A CB   1 
ATOM   4596 H H    . ALA   B 1 85  ? -0.56918  -23.35589 18.01526  1.000 28.33754 ? 563 ALA   A H    1 
ATOM   4597 H HA   . ALA   B 1 85  ? -2.51589  -21.82893 18.75298  1.000 32.68588 ? 563 ALA   A HA   1 
ATOM   4598 H HB1  . ALA   B 1 85  ? -3.46427  -23.77638 19.67972  1.000 32.17227 ? 563 ALA   A HB1  1 
ATOM   4599 H HB2  . ALA   B 1 85  ? -2.87952  -24.08431 18.23516  1.000 32.17227 ? 563 ALA   A HB2  1 
ATOM   4600 H HB3  . ALA   B 1 85  ? -2.06858  -24.52006 19.52977  1.000 32.17227 ? 563 ALA   A HB3  1 
ATOM   4601 N N    . ASP   B 1 86  ? -0.47517  -22.43542 21.12172  1.000 24.58879 ? 564 ASP   A N    1 
ATOM   4602 C CA   . ASP   B 1 86  ? -0.17078  -22.10995 22.50826  1.000 28.94834 ? 564 ASP   A CA   1 
ATOM   4603 C C    . ASP   B 1 86  ? 0.01489   -20.60664 22.71855  1.000 26.97161 ? 564 ASP   A C    1 
ATOM   4604 O O    . ASP   B 1 86  ? -0.13064  -20.12903 23.84620  1.000 28.78380 ? 564 ASP   A O    1 
ATOM   4605 C CB   . ASP   B 1 86  ? 1.08692   -22.85439 22.95539  1.000 37.92531 ? 564 ASP   A CB   1 
ATOM   4606 C CG   . ASP   B 1 86  ? 0.81367   -24.31010 23.31380  1.000 44.97887 ? 564 ASP   A CG   1 
ATOM   4607 O OD1  . ASP   B 1 86  ? -0.37065  -24.71099 23.41452  1.000 45.73157 ? 564 ASP   A OD1  1 
ATOM   4608 O OD2  . ASP   B 1 86  ? 1.79975   -25.05580 23.50052  1.000 59.71383 ? 564 ASP   A OD2  1 
ATOM   4609 H H    . ASP   B 1 86  ? 0.14311   -22.86653 20.70762  1.000 29.46057 ? 564 ASP   A H    1 
ATOM   4610 H HA   . ASP   B 1 86  ? -0.90736  -22.40272 23.06739  1.000 34.69202 ? 564 ASP   A HA   1 
ATOM   4611 H HB2  . ASP   B 1 86  ? 1.73607   -22.83961 22.23477  1.000 45.46438 ? 564 ASP   A HB2  1 
ATOM   4612 H HB3  . ASP   B 1 86  ? 1.45193   -22.41573 23.73977  1.000 45.46438 ? 564 ASP   A HB3  1 
ATOM   4613 N N    . SER   B 1 87  ? 0.32047   -19.86102 21.66294  1.000 23.98364 ? 565 SER   A N    1 
ATOM   4614 C CA   . SER   B 1 87  ? 0.52939   -18.42611 21.76416  1.000 24.33846 ? 565 SER   A CA   1 
ATOM   4615 C C    . SER   B 1 87  ? -0.74398  -17.60993 21.52196  1.000 21.28004 ? 565 SER   A C    1 
ATOM   4616 O O    . SER   B 1 87  ? -0.75156  -16.41675 21.80722  1.000 19.91439 ? 565 SER   A O    1 
ATOM   4617 C CB   . SER   B 1 87  ? 1.59396   -17.97825 20.75140  1.000 24.77045 ? 565 SER   A CB   1 
ATOM   4618 O OG   . SER   B 1 87  ? 2.85782   -18.56913 21.02741  1.000 26.08644 ? 565 SER   A OG   1 
ATOM   4619 H H    . SER   B 1 87  ? 0.41346   -20.16949 20.86557  1.000 28.73439 ? 565 SER   A H    1 
ATOM   4620 H HA   . SER   B 1 87  ? 0.84848   -18.22880 22.65867  1.000 29.16017 ? 565 SER   A HA   1 
ATOM   4621 H HB2  . SER   B 1 87  ? 1.31161   -18.24399 19.86227  1.000 29.67855 ? 565 SER   A HB2  1 
ATOM   4622 H HB3  . SER   B 1 87  ? 1.68287   -17.01339 20.79672  1.000 29.67855 ? 565 SER   A HB3  1 
ATOM   4623 H HG   . SER   B 1 87  ? 2.79855   -19.40608 20.98740  1.000 31.25775 ? 565 SER   A HG   1 
ATOM   4624 N N    . VAL   B 1 88  ? -1.80825  -18.22958 20.99092  1.000 20.19447 ? 566 VAL   A N    1 
ATOM   4625 C CA   . VAL   B 1 88  ? -2.98928  -17.47798 20.59227  1.000 17.29013 ? 566 VAL   A CA   1 
ATOM   4626 C C    . VAL   B 1 88  ? -3.64361  -16.76012 21.76863  1.000 17.66669 ? 566 VAL   A C    1 
ATOM   4627 O O    . VAL   B 1 88  ? -3.96790  -15.57469 21.63126  1.000 16.02520 ? 566 VAL   A O    1 
ATOM   4628 C CB   . VAL   B 1 88  ? -3.97752  -18.40452 19.86646  1.000 17.95240 ? 566 VAL   A CB   1 
ATOM   4629 C CG1  . VAL   B 1 88  ? -5.38845  -17.85860 19.92582  1.000 16.51260 ? 566 VAL   A CG1  1 
ATOM   4630 C CG2  . VAL   B 1 88  ? -3.52571  -18.64025 18.43948  1.000 19.98910 ? 566 VAL   A CG2  1 
ATOM   4631 H H    . VAL   B 1 88  ? -1.86482  -19.07686 20.85482  1.000 24.18738 ? 566 VAL   A H    1 
ATOM   4632 H HA   . VAL   B 1 88  ? -2.69093  -16.80101 19.96489  1.000 20.70217 ? 566 VAL   A HA   1 
ATOM   4633 H HB   . VAL   B 1 88  ? -3.99199  -19.26294 20.31791  1.000 21.49689 ? 566 VAL   A HB   1 
ATOM   4634 H HG11 . VAL   B 1 88  ? -5.93467  -18.32345 19.27277  1.000 19.76914 ? 566 VAL   A HG11 1 
ATOM   4635 H HG12 . VAL   B 1 88  ? -5.74494  -18.00096 20.81663  1.000 19.76914 ? 566 VAL   A HG12 1 
ATOM   4636 H HG13 . VAL   B 1 88  ? -5.36865  -16.90978 19.72519  1.000 19.76914 ? 566 VAL   A HG13 1 
ATOM   4637 H HG21 . VAL   B 1 88  ? -4.15132  -19.24109 18.00531  1.000 23.94093 ? 566 VAL   A HG21 1 
ATOM   4638 H HG22 . VAL   B 1 88  ? -3.50318  -17.79118 17.97101  1.000 23.94093 ? 566 VAL   A HG22 1 
ATOM   4639 H HG23 . VAL   B 1 88  ? -2.64012  -19.03588 18.44990  1.000 23.94093 ? 566 VAL   A HG23 1 
ATOM   4640 N N    . PRO   B 1 89  ? -3.88998  -17.39739 22.91631  1.000 16.53959 ? 567 PRO   A N    1 
ATOM   4641 C CA   . PRO   B 1 89  ? -4.53640  -16.65804 24.01830  1.000 18.52776 ? 567 PRO   A CA   1 
ATOM   4642 C C    . PRO   B 1 89  ? -3.73615  -15.42811 24.44113  1.000 18.54395 ? 567 PRO   A C    1 
ATOM   4643 O O    . PRO   B 1 89  ? -4.32168  -14.37217 24.69939  1.000 16.54229 ? 567 PRO   A O    1 
ATOM   4644 C CB   . PRO   B 1 89  ? -4.64851  -17.70678 25.13967  1.000 21.35325 ? 567 PRO   A CB   1 
ATOM   4645 C CG   . PRO   B 1 89  ? -4.64918  -19.00503 24.43200  1.000 21.24206 ? 567 PRO   A CG   1 
ATOM   4646 C CD   . PRO   B 1 89  ? -3.77874  -18.84353 23.20433  1.000 20.41542 ? 567 PRO   A CD   1 
ATOM   4647 H HA   . PRO   B 1 89  ? -5.43330  -16.38944 23.76468  1.000 22.18733 ? 567 PRO   A HA   1 
ATOM   4648 H HB2  . PRO   B 1 89  ? -3.88855  -17.63583 25.73827  1.000 25.57792 ? 567 PRO   A HB2  1 
ATOM   4649 H HB3  . PRO   B 1 89  ? -5.47322  -17.57809 25.63383  1.000 25.57792 ? 567 PRO   A HB3  1 
ATOM   4650 H HG2  . PRO   B 1 89  ? -4.28786  -19.69020 25.01586  1.000 25.44448 ? 567 PRO   A HG2  1 
ATOM   4651 H HG3  . PRO   B 1 89  ? -5.55696  -19.23193 24.17634  1.000 25.44448 ? 567 PRO   A HG3  1 
ATOM   4652 H HD2  . PRO   B 1 89  ? -2.86018  -19.09050 23.39449  1.000 24.45252 ? 567 PRO   A HD2  1 
ATOM   4653 H HD3  . PRO   B 1 89  ? -4.11828  -19.37231 22.46541  1.000 24.45252 ? 567 PRO   A HD3  1 
ATOM   4654 N N    . TYR   B 1 90  ? -2.42090  -15.55097 24.50119  1.000 17.45708 ? 568 TYR   A N    1 
ATOM   4655 C CA   . TYR   B 1 90  ? -1.57271  -14.41890 24.85791  1.000 17.81608 ? 568 TYR   A CA   1 
ATOM   4656 C C    . TYR   B 1 90  ? -1.72241  -13.27226 23.85603  1.000 16.59627 ? 568 TYR   A C    1 
ATOM   4657 O O    . TYR   B 1 90  ? -1.88270  -12.11373 24.24343  1.000 16.71201 ? 568 TYR   A O    1 
ATOM   4658 C CB   . TYR   B 1 90  ? -0.12127  -14.87200 24.94851  1.000 18.73711 ? 568 TYR   A CB   1 
ATOM   4659 C CG   . TYR   B 1 90  ? 0.80597   -13.75346 25.38898  1.000 18.19936 ? 568 TYR   A CG   1 
ATOM   4660 C CD1  . TYR   B 1 90  ? 1.29171   -12.83738 24.45981  1.000 19.26708 ? 568 TYR   A CD1  1 
ATOM   4661 C CD2  . TYR   B 1 90  ? 1.16100   -13.61564 26.71773  1.000 18.98033 ? 568 TYR   A CD2  1 
ATOM   4662 C CE1  . TYR   B 1 90  ? 2.09440   -11.81537 24.83897  1.000 18.58198 ? 568 TYR   A CE1  1 
ATOM   4663 C CE2  . TYR   B 1 90  ? 2.01455   -12.57541 27.10538  1.000 17.85953 ? 568 TYR   A CE2  1 
ATOM   4664 C CZ   . TYR   B 1 90  ? 2.44032   -11.67521 26.15195  1.000 20.19935 ? 568 TYR   A CZ   1 
ATOM   4665 O OH   . TYR   B 1 90  ? 3.25399   -10.60988 26.51986  1.000 24.11303 ? 568 TYR   A OH   1 
ATOM   4666 H H    . TYR   B 1 90  ? -1.98986  -16.27763 24.34069  1.000 20.90251 ? 568 TYR   A H    1 
ATOM   4667 H HA   . TYR   B 1 90  ? -1.84317  -14.08704 25.72832  1.000 21.33331 ? 568 TYR   A HA   1 
ATOM   4668 H HB2  . TYR   B 1 90  ? -0.05350  -15.59255 25.59436  1.000 22.43855 ? 568 TYR   A HB2  1 
ATOM   4669 H HB3  . TYR   B 1 90  ? 0.17006   -15.17999 24.07606  1.000 22.43855 ? 568 TYR   A HB3  1 
ATOM   4670 H HD1  . TYR   B 1 90  ? 1.06084   -12.92913 23.56361  1.000 23.07451 ? 568 TYR   A HD1  1 
ATOM   4671 H HD2  . TYR   B 1 90  ? 0.83406   -14.21182 27.35222  1.000 22.73041 ? 568 TYR   A HD2  1 
ATOM   4672 H HE1  . TYR   B 1 90  ? 2.40928   -11.21044 24.20666  1.000 22.25239 ? 568 TYR   A HE1  1 
ATOM   4673 H HE2  . TYR   B 1 90  ? 2.28927   -12.49328 27.99007  1.000 21.38545 ? 568 TYR   A HE2  1 
ATOM   4674 H HH   . TYR   B 1 90  ? 3.30304   -10.05525 25.89091  1.000 28.88965 ? 568 TYR   A HH   1 
ATOM   4675 N N    . VAL   B 1 91  ? -1.61973  -13.57153 22.56427  1.000 14.95473 ? 569 VAL   A N    1 
ATOM   4676 C CA   . VAL   B 1 91  ? -1.71346  -12.53124 21.55600  1.000 17.17215 ? 569 VAL   A CA   1 
ATOM   4677 C C    . VAL   B 1 91  ? -3.06364  -11.83613 21.63958  1.000 15.37752 ? 569 VAL   A C    1 
ATOM   4678 O O    . VAL   B 1 91  ? -3.14877  -10.60698 21.58321  1.000 15.00919 ? 569 VAL   A O    1 
ATOM   4679 C CB   . VAL   B 1 91  ? -1.44682  -13.11155 20.15195  1.000 16.30788 ? 569 VAL   A CB   1 
ATOM   4680 C CG1  . VAL   B 1 91  ? -1.74765  -12.08790 19.08427  1.000 16.02001 ? 569 VAL   A CG1  1 
ATOM   4681 C CG2  . VAL   B 1 91  ? -0.02353  -13.62153 20.04066  1.000 17.70772 ? 569 VAL   A CG2  1 
ATOM   4682 H H    . VAL   B 1 91  ? -1.49671  -14.36300 22.25117  1.000 17.89969 ? 569 VAL   A H    1 
ATOM   4683 H HA   . VAL   B 1 91  ? -1.02900  -11.86671 21.73155  1.000 20.56059 ? 569 VAL   A HA   1 
ATOM   4684 H HB   . VAL   B 1 91  ? -2.03920  -13.86638 20.00978  1.000 19.52347 ? 569 VAL   A HB   1 
ATOM   4685 H HG11 . VAL   B 1 91  ? -1.33336  -12.36754 18.25297  1.000 19.17803 ? 569 VAL   A HG11 1 
ATOM   4686 H HG12 . VAL   B 1 91  ? -2.70876  -12.02409 18.96979  1.000 19.17803 ? 569 VAL   A HG12 1 
ATOM   4687 H HG13 . VAL   B 1 91  ? -1.38966  -11.22954 19.35990  1.000 19.17803 ? 569 VAL   A HG13 1 
ATOM   4688 H HG21 . VAL   B 1 91  ? 0.11572   -13.97711 19.14899  1.000 21.20328 ? 569 VAL   A HG21 1 
ATOM   4689 H HG22 . VAL   B 1 91  ? 0.58876   -12.88696 20.20318  1.000 21.20328 ? 569 VAL   A HG22 1 
ATOM   4690 H HG23 . VAL   B 1 91  ? 0.11442   -14.31924 20.70027  1.000 21.20328 ? 569 VAL   A HG23 1 
ATOM   4691 N N    . ASN   B 1 92  ? -4.14615  -12.60887 21.73792  1.000 16.75881 ? 570 ASN   A N    1 
ATOM   4692 C CA   . ASN   B 1 92  ? -5.46363  -11.99347 21.80349  1.000 14.82063 ? 570 ASN   A CA   1 
ATOM   4693 C C    . ASN   B 1 92  ? -5.53200  -10.97123 22.91817  1.000 16.20919 ? 570 ASN   A C    1 
ATOM   4694 O O    . ASN   B 1 92  ? -6.21748  -9.96993  22.79585  1.000 17.04159 ? 570 ASN   A O    1 
ATOM   4695 C CB   . ASN   B 1 92  ? -6.55954  -13.06491 22.03504  1.000 17.71843 ? 570 ASN   A CB   1 
ATOM   4696 C CG   . ASN   B 1 92  ? -6.66332  -14.08749 20.89860  1.000 16.92486 ? 570 ASN   A CG   1 
ATOM   4697 O OD1  . ASN   B 1 92  ? -6.14782  -13.91395 19.81390  1.000 16.20204 ? 570 ASN   A OD1  1 
ATOM   4698 N ND2  . ASN   B 1 92  ? -7.35503  -15.17335 21.18110  1.000 17.49138 ? 570 ASN   A ND2  1 
ATOM   4699 H H    . ASN   B 1 92  ? -4.14209  -13.46835 21.76754  1.000 20.06458 ? 570 ASN   A H    1 
ATOM   4700 H HA   . ASN   B 1 92  ? -5.63279  -11.55780 20.95350  1.000 17.73877 ? 570 ASN   A HA   1 
ATOM   4701 H HB2  . ASN   B 1 92  ? -6.35782  -13.54803 22.85162  1.000 21.21613 ? 570 ASN   A HB2  1 
ATOM   4702 H HB3  . ASN   B 1 92  ? -7.41878  -12.62199 22.11525  1.000 21.21613 ? 570 ASN   A HB3  1 
ATOM   4703 H HD21 . ASN   B 1 92  ? -7.45223  -15.78786 20.58736  1.000 20.94367 ? 570 ASN   A HD21 1 
ATOM   4704 H HD22 . ASN   B 1 92  ? -7.70915  -15.26731 21.95916  1.000 20.94367 ? 570 ASN   A HD22 1 
ATOM   4705 N N    . GLN   B 1 93  ? -4.90664  -11.26963 24.05695  1.000 16.84985 ? 571 GLN   A N    1 
ATOM   4706 C CA   . GLN   B 1 93  ? -5.01016  -10.44427 25.25668  1.000 17.93385 ? 571 GLN   A CA   1 
ATOM   4707 C C    . GLN   B 1 93  ? -3.92271  -9.38519  25.34478  1.000 17.34447 ? 571 GLN   A C    1 
ATOM   4708 O O    . GLN   B 1 93  ? -4.18851  -8.27121  25.83982  1.000 17.93117 ? 571 GLN   A O    1 
ATOM   4709 C CB   . GLN   B 1 93  ? -4.93540  -11.32531 26.51087  1.000 21.34436 ? 571 GLN   A CB   1 
ATOM   4710 C CG   . GLN   B 1 93  ? -6.17965  -12.15741 26.75396  1.000 36.55111 ? 571 GLN   A CG   1 
ATOM   4711 C CD   . GLN   B 1 93  ? -7.16180  -11.45789 27.67516  1.000 42.89645 ? 571 GLN   A CD   1 
ATOM   4712 O OE1  . GLN   B 1 93  ? -7.05608  -10.23349 27.91881  1.000 32.43955 ? 571 GLN   A OE1  1 
ATOM   4713 N NE2  . GLN   B 1 93  ? -8.09604  -12.22650 28.21388  1.000 43.15959 ? 571 GLN   A NE2  1 
ATOM   4714 H H    . GLN   B 1 93  ? -4.40539  -11.96057 24.16153  1.000 20.17384 ? 571 GLN   A H    1 
ATOM   4715 H HA   . GLN   B 1 93  ? -5.87034  -9.99650  25.23427  1.000 21.47463 ? 571 GLN   A HA   1 
ATOM   4716 H HB2  . GLN   B 1 93  ? -4.18614  -11.93445 26.41883  1.000 25.56725 ? 571 GLN   A HB2  1 
ATOM   4717 H HB3  . GLN   B 1 93  ? -4.80596  -10.75470 27.28453  1.000 25.56725 ? 571 GLN   A HB3  1 
ATOM   4718 H HG2  . GLN   B 1 93  ? -6.62328  -12.32240 25.90728  1.000 43.81534 ? 571 GLN   A HG2  1 
ATOM   4719 H HG3  . GLN   B 1 93  ? -5.92542  -12.99855 27.16474  1.000 43.81534 ? 571 GLN   A HG3  1 
ATOM   4720 H HE21 . GLN   B 1 93  ? -8.11828  -13.06700 28.03318  1.000 51.74552 ? 571 GLN   A HE21 1 
ATOM   4721 H HE22 . GLN   B 1 93  ? -8.68048  -11.88512 28.74443  1.000 51.74552 ? 571 GLN   A HE22 1 
ATOM   4722 N N    . HIS   B 1 94  ? -2.72605  -9.72703  24.89240  1.000 17.13745 ? 572 HIS   A N    1 
ATOM   4723 C CA   . HIS   B 1 94  ? -1.54262  -8.90099  25.13375  1.000 16.38194 ? 572 HIS   A CA   1 
ATOM   4724 C C    . HIS   B 1 94  ? -0.82723  -8.46338  23.87849  1.000 17.97924 ? 572 HIS   A C    1 
ATOM   4725 O O    . HIS   B 1 94  ? 0.11450   -7.67929  23.98834  1.000 16.78495 ? 572 HIS   A O    1 
ATOM   4726 C CB   . HIS   B 1 94  ? -0.54362  -9.64810  26.04034  1.000 17.43349 ? 572 HIS   A CB   1 
ATOM   4727 C CG   . HIS   B 1 94  ? -1.10401  -9.96105  27.39513  1.000 20.10824 ? 572 HIS   A CG   1 
ATOM   4728 N ND1  . HIS   B 1 94  ? -1.42960  -8.98501  28.31746  1.000 24.20933 ? 572 HIS   A ND1  1 
ATOM   4729 C CD2  . HIS   B 1 94  ? -1.44395  -11.14465 27.96287  1.000 20.44096 ? 572 HIS   A CD2  1 
ATOM   4730 C CE1  . HIS   B 1 94  ? -1.91955  -9.55934  29.39892  1.000 24.14302 ? 572 HIS   A CE1  1 
ATOM   4731 N NE2  . HIS   B 1 94  ? -1.95062  -10.86257 29.20247  1.000 20.28724 ? 572 HIS   A NE2  1 
ATOM   4732 H H    . HIS   B 1 94  ? -2.56717  -10.43948 24.43767  1.000 20.51895 ? 572 HIS   A H    1 
ATOM   4733 H HA   . HIS   B 1 94  ? -1.82548  -8.09791  25.59845  1.000 19.61234 ? 572 HIS   A HA   1 
ATOM   4734 H HB2  . HIS   B 1 94  ? -0.29939  -10.48576 25.61658  1.000 20.87420 ? 572 HIS   A HB2  1 
ATOM   4735 H HB3  . HIS   B 1 94  ? 0.24449   -9.09597  26.16257  1.000 20.87420 ? 572 HIS   A HB3  1 
ATOM   4736 H HD2  . HIS   B 1 94  ? -1.35052  -11.98799 27.58214  1.000 24.48317 ? 572 HIS   A HD2  1 
ATOM   4737 H HE1  . HIS   B 1 94  ? -2.19640  -9.11923  30.17000  1.000 28.92563 ? 572 HIS   A HE1  1 
ATOM   4738 H HE2  . HIS   B 1 94  ? -2.24318  -11.44387 29.76470  1.000 24.29871 ? 572 HIS   A HE2  1 
ATOM   4739 N N    . GLY   B 1 95  ? -1.23164  -8.94170  22.70637  1.000 16.32035 ? 573 GLY   A N    1 
ATOM   4740 C CA   . GLY   B 1 95  ? -0.57267  -8.51388  21.49188  1.000 17.03423 ? 573 GLY   A CA   1 
ATOM   4741 C C    . GLY   B 1 95  ? 0.74121   -9.23858  21.25738  1.000 19.81940 ? 573 GLY   A C    1 
ATOM   4742 O O    . GLY   B 1 95  ? 0.96731   -10.34344 21.71874  1.000 17.24808 ? 573 GLY   A O    1 
ATOM   4743 H H    . GLY   B 1 95  ? -1.87302  -9.50366  22.59487  1.000 19.53843 ? 573 GLY   A H    1 
ATOM   4744 H HA2  . GLY   B 1 95  ? -1.15430  -8.68388  20.73445  1.000 20.39509 ? 573 GLY   A HA2  1 
ATOM   4745 H HA3  . GLY   B 1 95  ? -0.39132  -7.56239  21.54349  1.000 20.39509 ? 573 GLY   A HA3  1 
ATOM   4746 N N    . PHE   B 1 96  ? 1.62275   -8.58601  20.53250  1.000 18.16767 ? 574 PHE   A N    1 
ATOM   4747 C CA   . PHE   B 1 96  ? 2.83463   -9.20630  20.02712  1.000 20.51983 ? 574 PHE   A CA   1 
ATOM   4748 C C    . PHE   B 1 96  ? 4.01542   -8.71832  20.85038  1.000 21.82932 ? 574 PHE   A C    1 
ATOM   4749 O O    . PHE   B 1 96  ? 4.24695   -7.51655  20.96079  1.000 25.37959 ? 574 PHE   A O    1 
ATOM   4750 C CB   . PHE   B 1 96  ? 3.01895   -8.88058  18.53249  1.000 21.52738 ? 574 PHE   A CB   1 
ATOM   4751 C CG   . PHE   B 1 96  ? 1.91407   -9.45153  17.68469  1.000 20.94184 ? 574 PHE   A CG   1 
ATOM   4752 C CD1  . PHE   B 1 96  ? 1.92722   -10.78013 17.32827  1.000 18.92577 ? 574 PHE   A CD1  1 
ATOM   4753 C CD2  . PHE   B 1 96  ? 0.87438   -8.65440  17.26950  1.000 18.19265 ? 574 PHE   A CD2  1 
ATOM   4754 C CE1  . PHE   B 1 96  ? 0.90563   -11.32749 16.57775  1.000 20.13690 ? 574 PHE   A CE1  1 
ATOM   4755 C CE2  . PHE   B 1 96  ? -0.16425  -9.19417  16.50805  1.000 18.12704 ? 574 PHE   A CE2  1 
ATOM   4756 C CZ   . PHE   B 1 96  ? -0.14261  -10.53946 16.17298  1.000 17.95414 ? 574 PHE   A CZ   1 
ATOM   4757 H H    . PHE   B 1 96  ? 1.54251   -7.75877  20.31152  1.000 21.75522 ? 574 PHE   A H    1 
ATOM   4758 H HA   . PHE   B 1 96  ? 2.78845   -10.17128 20.11417  1.000 24.57781 ? 574 PHE   A HA   1 
ATOM   4759 H HB2  . PHE   B 1 96  ? 3.02340   -7.91770  18.41530  1.000 25.78687 ? 574 PHE   A HB2  1 
ATOM   4760 H HB3  . PHE   B 1 96  ? 3.85955   -9.25588  18.22680  1.000 25.78687 ? 574 PHE   A HB3  1 
ATOM   4761 H HD1  . PHE   B 1 96  ? 2.63607   -11.31869 17.59733  1.000 22.66494 ? 574 PHE   A HD1  1 
ATOM   4762 H HD2  . PHE   B 1 96  ? 0.86252   -7.75258  17.49639  1.000 21.78520 ? 574 PHE   A HD2  1 
ATOM   4763 H HE1  . PHE   B 1 96  ? 0.92781   -12.22814 16.34703  1.000 24.11830 ? 574 PHE   A HE1  1 
ATOM   4764 H HE2  . PHE   B 1 96  ? -0.86714  -8.65393  16.22701  1.000 21.70646 ? 574 PHE   A HE2  1 
ATOM   4765 H HZ   . PHE   B 1 96  ? -0.83683  -10.90697 15.67508  1.000 21.49898 ? 574 PHE   A HZ   1 
ATOM   4766 N N    . ASN   B 1 97  ? 4.75308   -9.66404  21.39926  1.000 19.40586 ? 575 ASN   A N    1 
ATOM   4767 C CA   . ASN   B 1 97  ? 5.81931   -9.43209  22.37306  1.000 19.68720 ? 575 ASN   A CA   1 
ATOM   4768 C C    . ASN   B 1 97  ? 7.11798   -9.99538  21.82278  1.000 21.99701 ? 575 ASN   A C    1 
ATOM   4769 O O    . ASN   B 1 97  ? 7.26904   -11.21649 21.70629  1.000 20.67007 ? 575 ASN   A O    1 
ATOM   4770 C CB   . ASN   B 1 97  ? 5.45448   -10.09631 23.69515  1.000 20.43832 ? 575 ASN   A CB   1 
ATOM   4771 C CG   . ASN   B 1 97  ? 6.42543   -9.77827  24.78557  1.000 20.90225 ? 575 ASN   A CG   1 
ATOM   4772 O OD1  . ASN   B 1 97  ? 7.57486   -9.42744  24.50289  1.000 19.42950 ? 575 ASN   A OD1  1 
ATOM   4773 N ND2  . ASN   B 1 97  ? 5.97700   -9.92905  26.04212  1.000 21.41251 ? 575 ASN   A ND2  1 
ATOM   4774 H H    . ASN   B 1 97  ? 4.65430   -10.49874 21.21728  1.000 23.24105 ? 575 ASN   A H    1 
ATOM   4775 H HA   . ASN   B 1 97  ? 5.94479   -8.47988  22.50893  1.000 23.57865 ? 575 ASN   A HA   1 
ATOM   4776 H HB2  . ASN   B 1 97  ? 4.57819   -9.78726  23.97352  1.000 24.48000 ? 575 ASN   A HB2  1 
ATOM   4777 H HB3  . ASN   B 1 97  ? 5.44373   -11.05861 23.57363  1.000 24.48000 ? 575 ASN   A HB3  1 
ATOM   4778 H HD21 . ASN   B 1 97  ? 6.49546   -9.75941  26.70697  1.000 25.64903 ? 575 ASN   A HD21 1 
ATOM   4779 H HD22 . ASN   B 1 97  ? 5.17132   -10.19527 26.18211  1.000 25.64903 ? 575 ASN   A HD22 1 
ATOM   4780 N N    . ARG   B 1 98  ? 8.07276   -9.10216  21.52596  1.000 18.24382 ? 576 ARG   A N    1 
ATOM   4781 C CA   . ARG   B 1 98  ? 9.34074   -9.52857  20.94882  1.000 18.64789 ? 576 ARG   A CA   1 
ATOM   4782 C C    . ARG   B 1 98  ? 10.12928  -10.44436 21.86539  1.000 22.03390 ? 576 ARG   A C    1 
ATOM   4783 O O    . ARG   B 1 98  ? 11.03376  -11.13887 21.39214  1.000 22.50505 ? 576 ARG   A O    1 
ATOM   4784 C CB   . ARG   B 1 98  ? 10.17900  -8.30480  20.58712  1.000 18.12830 ? 576 ARG   A CB   1 
ATOM   4785 C CG   . ARG   B 1 98  ? 10.59858  -7.47672  21.79653  1.000 18.61009 ? 576 ARG   A CG   1 
ATOM   4786 C CD   . ARG   B 1 98  ? 11.17432  -6.12652  21.35788  1.000 19.24642 ? 576 ARG   A CD   1 
ATOM   4787 N NE   . ARG   B 1 98  ? 11.55057  -5.25221  22.46804  1.000 16.09979 ? 576 ARG   A NE   1 
ATOM   4788 C CZ   . ARG   B 1 98  ? 10.70804  -4.46566  23.12166  1.000 18.07393 ? 576 ARG   A CZ   1 
ATOM   4789 N NH1  . ARG   B 1 98  ? 9.41628   -4.51601  22.90355  1.000 16.48317 ? 576 ARG   A NH1  1 
ATOM   4790 N NH2  . ARG   B 1 98  ? 11.17950  -3.58826  23.99888  1.000 16.68723 ? 576 ARG   A NH2  1 
ATOM   4791 H H    . ARG   B 1 98  ? 8.00613   -8.25377  21.65000  1.000 21.84660 ? 576 ARG   A H    1 
ATOM   4792 H HA   . ARG   B 1 98  ? 9.15590   -10.02556 20.13658  1.000 22.33149 ? 576 ARG   A HA   1 
ATOM   4793 H HB2  . ARG   B 1 98  ? 10.98477  -8.60006  20.13496  1.000 21.70798 ? 576 ARG   A HB2  1 
ATOM   4794 H HB3  . ARG   B 1 98  ? 9.66015   -7.73248  20.00048  1.000 21.70798 ? 576 ARG   A HB3  1 
ATOM   4795 H HG2  . ARG   B 1 98  ? 9.82678   -7.31351  22.36098  1.000 22.28612 ? 576 ARG   A HG2  1 
ATOM   4796 H HG3  . ARG   B 1 98  ? 11.27959  -7.95422  22.29565  1.000 22.28612 ? 576 ARG   A HG3  1 
ATOM   4797 H HD2  . ARG   B 1 98  ? 11.96934  -6.28501  20.82523  1.000 23.04972 ? 576 ARG   A HD2  1 
ATOM   4798 H HD3  . ARG   B 1 98  ? 10.50796  -5.66069  20.82884  1.000 23.04972 ? 576 ARG   A HD3  1 
ATOM   4799 H HE   . ARG   B 1 98  ? 12.37481  -5.24827  22.71342  1.000 19.27376 ? 576 ARG   A HE   1 
ATOM   4800 H HH11 . ARG   B 1 98  ? 9.09898   -5.06822  22.32563  1.000 19.73382 ? 576 ARG   A HH11 1 
ATOM   4801 H HH12 . ARG   B 1 98  ? 8.88621   -3.99684  23.33839  1.000 19.73382 ? 576 ARG   A HH12 1 
ATOM   4802 H HH21 . ARG   B 1 98  ? 12.02615  -3.53336  24.13954  1.000 19.97869 ? 576 ARG   A HH21 1 
ATOM   4803 H HH22 . ARG   B 1 98  ? 10.63835  -3.07466  24.42663  1.000 19.97869 ? 576 ARG   A HH22 1 
ATOM   4804 N N    . SER   B 1 99  ? 9.84141   -10.43731 23.16312  1.000 18.81713 ? 577 SER   A N    1 
ATOM   4805 C CA   . SER   B 1 99  ? 10.55556  -11.28198 24.10142  1.000 22.44359 ? 577 SER   A CA   1 
ATOM   4806 C C    . SER   B 1 99  ? 10.11874  -12.73401 24.03287  1.000 28.76306 ? 577 SER   A C    1 
ATOM   4807 O O    . SER   B 1 99  ? 10.74853  -13.56771 24.68453  1.000 25.14325 ? 577 SER   A O    1 
ATOM   4808 C CB   . SER   B 1 99  ? 10.37653  -10.75611 25.52601  1.000 22.33452 ? 577 SER   A CB   1 
ATOM   4809 O OG   . SER   B 1 99  ? 10.81100  -9.41306  25.55264  1.000 18.90519 ? 577 SER   A OG   1 
ATOM   4810 H H    . SER   B 1 99  ? 9.23267   -9.94807  23.52323  1.000 22.53457 ? 577 SER   A H    1 
ATOM   4811 H HA   . SER   B 1 99  ? 11.50227  -11.24698 23.89305  1.000 26.88632 ? 577 SER   A HA   1 
ATOM   4812 H HB2  . SER   B 1 99  ? 9.44056   -10.80215 25.77647  1.000 26.75544 ? 577 SER   A HB2  1 
ATOM   4813 H HB3  . SER   B 1 99  ? 10.91049  -11.28485 26.13938  1.000 26.75544 ? 577 SER   A HB3  1 
ATOM   4814 H HG   . SER   B 1 99  ? 11.12522  -9.22770  26.30928  1.000 22.64024 ? 577 SER   A HG   1 
ATOM   4815 N N    . CYS   B 1 100 ? 9.06109   -13.04184 23.28178  1.000 27.02505 ? 578 CYS   A N    1 
ATOM   4816 C CA   . CYS   B 1 100 ? 8.62688   -14.42931 23.09710  1.000 38.33521 ? 578 CYS   A CA   1 
ATOM   4817 C C    . CYS   B 1 100 ? 9.17165   -15.05681 21.81647  1.000 42.18028 ? 578 CYS   A C    1 
ATOM   4818 O O    . CYS   B 1 100 ? 8.81895   -16.19676 21.49696  1.000 51.49520 ? 578 CYS   A O    1 
ATOM   4819 C CB   . CYS   B 1 100 ? 7.09731   -14.50925 23.09122  1.000 29.19557 ? 578 CYS   A CB   1 
ATOM   4820 S SG   . CYS   B 1 100 ? 6.27971   -13.99679 24.64120  1.000 47.83944 ? 578 CYS   A SG   1 
ATOM   4821 H H    . CYS   B 1 100 ? 8.57715   -12.46402 22.86763  1.000 32.38407 ? 578 CYS   A H    1 
ATOM   4822 H HA   . CYS   B 1 100 ? 8.95056   -14.95258 23.84699  1.000 45.95626 ? 578 CYS   A HA   1 
ATOM   4823 H HB2  . CYS   B 1 100 ? 6.76432   -13.93392 22.38481  1.000 34.98870 ? 578 CYS   A HB2  1 
ATOM   4824 H HB3  . CYS   B 1 100 ? 6.84038   -15.42863 22.91911  1.000 34.98870 ? 578 CYS   A HB3  1 
ATOM   4825 H HG   . CYS   B 1 100 ? 5.09204   -14.11022 24.51242  1.000 57.36135 ? 578 CYS   A HG   1 
ATOM   4826 N N    . ALA   B 1 101 ? 10.00336  -14.33833 21.07222  1.000 36.31510 ? 579 ALA   A N    1 
ATOM   4827 C CA   . ALA   B 1 101 ? 10.56137  -14.85071 19.82850  1.000 44.19193 ? 579 ALA   A CA   1 
ATOM   4828 C C    . ALA   B 1 101 ? 11.38478  -16.10997 20.06084  1.000 44.65182 ? 579 ALA   A C    1 
ATOM   4829 O O    . ALA   B 1 101 ? 11.99531  -16.26171 21.10825  1.000 51.60008 ? 579 ALA   A O    1 
ATOM   4830 C CB   . ALA   B 1 101 ? 11.41756  -13.78756 19.15190  1.000 39.70384 ? 579 ALA   A CB   1 
ATOM   4831 H H    . ALA   B 1 101 ? 10.26283  -13.54218 21.26823  1.000 43.53213 ? 579 ALA   A H    1 
ATOM   4832 H HA   . ALA   B 1 101 ? 9.82736   -15.07835 19.23663  1.000 52.98434 ? 579 ALA   A HA   1 
ATOM   4833 H HB1  . ALA   B 1 101 ? 11.77862  -14.15021 18.32787  1.000 47.59862 ? 579 ALA   A HB1  1 
ATOM   4834 H HB2  . ALA   B 1 101 ? 10.86578  -13.01350 18.95885  1.000 47.59862 ? 579 ALA   A HB2  1 
ATOM   4835 H HB3  . ALA   B 1 101 ? 12.14070  -13.53786 19.74824  1.000 47.59862 ? 579 ALA   A HB3  1 
ATOM   4836 N N    . ALA   B 1 105 ? 15.29915  -17.25734 13.04292  1.000 46.74742 ? 583 ALA   A N    1 
ATOM   4837 C CA   . ALA   B 1 105 ? 14.13500  -16.80551 13.79986  1.000 51.54942 ? 583 ALA   A CA   1 
ATOM   4838 C C    . ALA   B 1 105 ? 14.09186  -15.28246 13.91429  1.000 45.25653 ? 583 ALA   A C    1 
ATOM   4839 O O    . ALA   B 1 105 ? 12.99981  -14.68376 14.05182  1.000 40.61300 ? 583 ALA   A O    1 
ATOM   4840 C CB   . ALA   B 1 105 ? 14.13374  -17.44036 15.19165  1.000 41.36143 ? 583 ALA   A CB   1 
ATOM   4841 H HA   . ALA   B 1 105 ? 13.33408  -17.08676 13.33046  1.000 61.81332 ? 583 ALA   A HA   1 
ATOM   4842 H HB1  . ALA   B 1 105 ? 13.35541  -17.12937 15.67990  1.000 49.58774 ? 583 ALA   A HB1  1 
ATOM   4843 H HB2  . ALA   B 1 105 ? 14.10200  -18.40536 15.09855  1.000 49.58774 ? 583 ALA   A HB2  1 
ATOM   4844 H HB3  . ALA   B 1 105 ? 14.94303  -17.17953 15.65846  1.000 49.58774 ? 583 ALA   A HB3  1 
ATOM   4845 N N    . VAL   B 1 106 ? 15.27216  -14.65962 13.84336  1.000 38.37880 ? 584 VAL   A N    1 
ATOM   4846 C CA   . VAL   B 1 106 ? 15.40607  -13.21643 14.03094  1.000 35.89605 ? 584 VAL   A CA   1 
ATOM   4847 C C    . VAL   B 1 106 ? 16.51120  -12.67134 13.12032  1.000 32.04163 ? 584 VAL   A C    1 
ATOM   4848 O O    . VAL   B 1 106 ? 17.30879  -11.79741 13.51768  1.000 25.50479 ? 584 VAL   A O    1 
ATOM   4849 C CB   . VAL   B 1 106 ? 15.69100  -12.87667 15.50587  1.000 37.01449 ? 584 VAL   A CB   1 
ATOM   4850 C CG1  . VAL   B 1 106 ? 14.41676  -13.00866 16.34374  1.000 34.44967 ? 584 VAL   A CG1  1 
ATOM   4851 C CG2  . VAL   B 1 106 ? 16.80374  -13.78506 16.06551  1.000 36.58647 ? 584 VAL   A CG2  1 
ATOM   4852 H H    . VAL   B 1 106 ? 16.01789  -15.05791 13.68568  1.000 46.00857 ? 584 VAL   A H    1 
ATOM   4853 H HA   . VAL   B 1 106 ? 14.57331  -12.79253 13.77070  1.000 43.02927 ? 584 VAL   A HA   1 
ATOM   4854 H HB   . VAL   B 1 106 ? 15.99514  -11.95723 15.56100  1.000 44.37140 ? 584 VAL   A HB   1 
ATOM   4855 H HG11 . VAL   B 1 106 ? 14.60814  -12.73589 17.25471  1.000 41.29362 ? 584 VAL   A HG11 1 
ATOM   4856 H HG12 . VAL   B 1 106 ? 13.72942  -12.43843 15.96519  1.000 41.29362 ? 584 VAL   A HG12 1 
ATOM   4857 H HG13 . VAL   B 1 106 ? 14.12407  -13.93334 16.32989  1.000 41.29362 ? 584 VAL   A HG13 1 
ATOM   4858 H HG21 . VAL   B 1 106 ? 17.06702  -13.45944 16.94047  1.000 43.85778 ? 584 VAL   A HG21 1 
ATOM   4859 H HG22 . VAL   B 1 106 ? 16.46515  -14.69116 16.13789  1.000 43.85778 ? 584 VAL   A HG22 1 
ATOM   4860 H HG23 . VAL   B 1 106 ? 17.56288  -13.76283 15.46209  1.000 43.85778 ? 584 VAL   A HG23 1 
ATOM   4861 N N    . SER   B 1 107 ? 16.52525  -13.15784 11.87494  1.000 30.35954 ? 585 SER   A N    1 
ATOM   4862 C CA   . SER   B 1 107 ? 17.56632  -12.81124 10.92505  1.000 25.00259 ? 585 SER   A CA   1 
ATOM   4863 C C    . SER   B 1 107 ? 17.60261  -11.32507 10.60017  1.000 23.87414 ? 585 SER   A C    1 
ATOM   4864 O O    . SER   B 1 107 ? 18.63621  -10.83042 10.17684  1.000 21.22529 ? 585 SER   A O    1 
ATOM   4865 C CB   . SER   B 1 107 ? 17.36369  -13.60355 9.61801   1.000 28.16331 ? 585 SER   A CB   1 
ATOM   4866 O OG   . SER   B 1 107 ? 17.56185  -14.98897 9.82592   1.000 37.98870 ? 585 SER   A OG   1 
ATOM   4867 H H    . SER   B 1 107 ? 15.93385  -13.69597 11.55830  1.000 36.38546 ? 585 SER   A H    1 
ATOM   4868 H HA   . SER   B 1 107 ? 18.42074  -13.05289 11.31553  1.000 29.95712 ? 585 SER   A HA   1 
ATOM   4869 H HB2  . SER   B 1 107 ? 16.45882  -13.45937 9.29969   1.000 33.74999 ? 585 SER   A HB2  1 
ATOM   4870 H HB3  . SER   B 1 107 ? 18.00151  -13.29002 8.95787   1.000 33.74999 ? 585 SER   A HB3  1 
ATOM   4871 H HG   . SER   B 1 107 ? 17.01643  -15.27464 10.39733  1.000 45.54045 ? 585 SER   A HG   1 
ATOM   4872 N N    . TYR   B 1 108 ? 16.49255  -10.60422 10.74967  1.000 18.60418 ? 586 TYR   A N    1 
ATOM   4873 C CA   . TYR   B 1 108 ? 16.46959  -9.18940  10.43003  1.000 17.80983 ? 586 TYR   A CA   1 
ATOM   4874 C C    . TYR   B 1 108 ? 16.32823  -8.33423  11.67851  1.000 16.24814 ? 586 TYR   A C    1 
ATOM   4875 O O    . TYR   B 1 108 ? 16.07877  -7.11632  11.55704  1.000 16.87898 ? 586 TYR   A O    1 
ATOM   4876 C CB   . TYR   B 1 108 ? 15.36556  -8.88784  9.41567   1.000 17.18181 ? 586 TYR   A CB   1 
ATOM   4877 C CG   . TYR   B 1 108 ? 15.72724  -9.46243  8.05903   1.000 18.27152 ? 586 TYR   A CG   1 
ATOM   4878 C CD1  . TYR   B 1 108 ? 16.57668  -8.78840  7.20701   1.000 18.61125 ? 586 TYR   A CD1  1 
ATOM   4879 C CD2  . TYR   B 1 108 ? 15.25215  -10.70540 7.66475   1.000 20.33404 ? 586 TYR   A CD2  1 
ATOM   4880 C CE1  . TYR   B 1 108 ? 16.95903  -9.33756  5.98293   1.000 19.19451 ? 586 TYR   A CE1  1 
ATOM   4881 C CE2  . TYR   B 1 108 ? 15.62743  -11.25448 6.45055   1.000 21.38859 ? 586 TYR   A CE2  1 
ATOM   4882 C CZ   . TYR   B 1 108 ? 16.47663  -10.57220 5.62297   1.000 21.42448 ? 586 TYR   A CZ   1 
ATOM   4883 O OH   . TYR   B 1 108 ? 16.85214  -11.09719 4.40838   1.000 21.56786 ? 586 TYR   A OH   1 
ATOM   4884 H H    . TYR   B 1 108 ? 15.74394  -10.91717 11.03470  1.000 22.27903 ? 586 TYR   A H    1 
ATOM   4885 H HA   . TYR   B 1 108 ? 17.30537  -8.94300  10.00381  1.000 21.32581 ? 586 TYR   A HA   1 
ATOM   4886 H HB2  . TYR   B 1 108 ? 14.53358  -9.28935  9.71146   1.000 20.57219 ? 586 TYR   A HB2  1 
ATOM   4887 H HB3  . TYR   B 1 108 ? 15.25787  -7.92784  9.32791   1.000 20.57219 ? 586 TYR   A HB3  1 
ATOM   4888 H HD1  . TYR   B 1 108 ? 16.90069  -7.95211  7.45306   1.000 22.28751 ? 586 TYR   A HD1  1 
ATOM   4889 H HD2  . TYR   B 1 108 ? 14.67497  -11.17494 8.22270   1.000 24.35487 ? 586 TYR   A HD2  1 
ATOM   4890 H HE1  . TYR   B 1 108 ? 17.53343  -8.87345  5.41763   1.000 22.98742 ? 586 TYR   A HE1  1 
ATOM   4891 H HE2  . TYR   B 1 108 ? 15.30190  -12.08800 6.19722   1.000 25.62033 ? 586 TYR   A HE2  1 
ATOM   4892 H HH   . TYR   B 1 108 ? 16.50443  -11.85453 4.30288   1.000 25.83545 ? 586 TYR   A HH   1 
ATOM   4893 N N    . GLY   B 1 109 ? 16.49627  -8.94211  12.86245  1.000 17.28728 ? 587 GLY   A N    1 
ATOM   4894 C CA   . GLY   B 1 109 ? 16.39533  -8.19100  14.10834  1.000 18.32023 ? 587 GLY   A CA   1 
ATOM   4895 C C    . GLY   B 1 109 ? 15.55592  -8.91856  15.14710  1.000 19.87827 ? 587 GLY   A C    1 
ATOM   4896 O O    . GLY   B 1 109 ? 14.76770  -9.80748  14.79737  1.000 18.81876 ? 587 GLY   A O    1 
ATOM   4897 H H    . GLY   B 1 109 ? 16.66736  -9.77889  12.96308  1.000 20.69875 ? 587 GLY   A H    1 
ATOM   4898 H HA2  . GLY   B 1 109 ? 17.28316  -8.05169  14.47340  1.000 21.93829 ? 587 GLY   A HA2  1 
ATOM   4899 H HA3  . GLY   B 1 109 ? 15.98728  -7.32874  13.93258  1.000 21.93829 ? 587 GLY   A HA3  1 
ATOM   4900 N N    . LYS   B 1 110 ? 15.71577  -8.55013  16.42057  1.000 17.05638 ? 588 LYS   A N    1 
ATOM   4901 C CA   . LYS   B 1 110 ? 15.01679  -9.20488  17.51797  1.000 19.58675 ? 588 LYS   A CA   1 
ATOM   4902 C C    . LYS   B 1 110 ? 13.73711  -8.43128  17.78223  1.000 18.59614 ? 588 LYS   A C    1 
ATOM   4903 O O    . LYS   B 1 110 ? 13.61409  -7.67688  18.74142  1.000 19.32881 ? 588 LYS   A O    1 
ATOM   4904 C CB   . LYS   B 1 110 ? 15.89290  -9.29091  18.75755  1.000 23.64999 ? 588 LYS   A CB   1 
ATOM   4905 C CG   . LYS   B 1 110 ? 17.09076  -10.24686 18.57286  1.000 31.34700 ? 588 LYS   A CG   1 
ATOM   4906 C CD   . LYS   B 1 110 ? 18.03179  -10.19160 19.77608  1.000 38.44610 ? 588 LYS   A CD   1 
ATOM   4907 C CE   . LYS   B 1 110 ? 19.19135  -11.16446 19.60291  1.000 49.50402 ? 588 LYS   A CE   1 
ATOM   4908 N NZ   . LYS   B 1 110 ? 20.24567  -10.97141 20.64399  1.000 51.08451 ? 588 LYS   A NZ   1 
ATOM   4909 H H    . LYS   B 1 110 ? 16.23350  -7.91211  16.67450  1.000 20.42168 ? 588 LYS   A H    1 
ATOM   4910 H HA   . LYS   B 1 110 ? 14.79095  -10.11083 17.25502  1.000 23.45812 ? 588 LYS   A HA   1 
ATOM   4911 H HB2  . LYS   B 1 110 ? 16.24063  -8.40849  18.96083  1.000 28.33400 ? 588 LYS   A HB2  1 
ATOM   4912 H HB3  . LYS   B 1 110 ? 15.35971  -9.61642  19.49961  1.000 28.33400 ? 588 LYS   A HB3  1 
ATOM   4913 H HG2  . LYS   B 1 110 ? 16.76631  -11.15620 18.47935  1.000 37.57041 ? 588 LYS   A HG2  1 
ATOM   4914 H HG3  . LYS   B 1 110 ? 17.58972  -9.98965  17.78179  1.000 37.57041 ? 588 LYS   A HG3  1 
ATOM   4915 H HD2  . LYS   B 1 110 ? 18.39263  -9.29552  19.86400  1.000 46.08933 ? 588 LYS   A HD2  1 
ATOM   4916 H HD3  . LYS   B 1 110 ? 17.54478  -10.43342 20.57935  1.000 46.08933 ? 588 LYS   A HD3  1 
ATOM   4917 H HE2  . LYS   B 1 110 ? 18.85886  -12.07295 19.67359  1.000 59.35884 ? 588 LYS   A HE2  1 
ATOM   4918 H HE3  . LYS   B 1 110 ? 19.59649  -11.02623 18.73248  1.000 59.35884 ? 588 LYS   A HE3  1 
ATOM   4919 H HZ1  . LYS   B 1 110 ? 19.89984  -11.09695 21.45438  1.000 61.25543 ? 588 LYS   A HZ1  1 
ATOM   4920 H HZ2  . LYS   B 1 110 ? 20.90717  -11.55353 20.51890  1.000 61.25543 ? 588 LYS   A HZ2  1 
ATOM   4921 H HZ3  . LYS   B 1 110 ? 20.57433  -10.14578 20.59493  1.000 61.25543 ? 588 LYS   A HZ3  1 
ATOM   4922 N N    . GLY   B 1 111 ? 12.75009  -8.67589  16.92032  1.000 17.45604 ? 589 GLY   A N    1 
ATOM   4923 C CA   . GLY   B 1 111 ? 11.43120  -8.08427  17.05476  1.000 15.99100 ? 589 GLY   A CA   1 
ATOM   4924 C C    . GLY   B 1 111 ? 10.35704  -9.08969  16.66003  1.000 15.23654 ? 589 GLY   A C    1 
ATOM   4925 O O    . GLY   B 1 111 ? 10.63559  -10.27551 16.53122  1.000 16.86236 ? 589 GLY   A O    1 
ATOM   4926 H H    . GLY   B 1 111 ? 12.82553  -9.19234  16.23681  1.000 20.90126 ? 589 GLY   A H    1 
ATOM   4927 H HA2  . GLY   B 1 111 ? 11.28495  -7.81250  17.97435  1.000 19.14321 ? 589 GLY   A HA2  1 
ATOM   4928 H HA3  . GLY   B 1 111 ? 11.35987  -7.30596  16.48028  1.000 19.14321 ? 589 GLY   A HA3  1 
ATOM   4929 N N    . THR   B 1 112 ? 9.14755   -8.61851  16.40003  1.000 15.04730 ? 590 THR   A N    1 
ATOM   4930 C CA   . THR   B 1 112 ? 8.06276   -9.46299  15.92115  1.000 16.99303 ? 590 THR   A CA   1 
ATOM   4931 C C    . THR   B 1 112 ? 7.98199   -9.31648  14.40769  1.000 15.28993 ? 590 THR   A C    1 
ATOM   4932 O O    . THR   B 1 112 ? 8.04649   -8.20427  13.87284  1.000 15.57380 ? 590 THR   A O    1 
ATOM   4933 C CB   . THR   B 1 112 ? 6.72321   -9.05775  16.56268  1.000 17.30063 ? 590 THR   A CB   1 
ATOM   4934 O OG1  . THR   B 1 112 ? 6.81589   -9.19168  17.98772  1.000 17.69956 ? 590 THR   A OG1  1 
ATOM   4935 C CG2  . THR   B 1 112 ? 5.60327   -9.97258  16.08596  1.000 19.79486 ? 590 THR   A CG2  1 
ATOM   4936 H H    . THR   B 1 112 ? 8.92435   -7.79344  16.49516  1.000 18.01077 ? 590 THR   A H    1 
ATOM   4937 H HA   . THR   B 1 112 ? 8.22563   -10.39135 16.15035  1.000 20.34565 ? 590 THR   A HA   1 
ATOM   4938 H HB   . THR   B 1 112 ? 6.52009   -8.14173  16.31660  1.000 20.71477 ? 590 THR   A HB   1 
ATOM   4939 H HG1  . THR   B 1 112 ? 7.42283   -8.69244  18.28433  1.000 21.19349 ? 590 THR   A HG1  1 
ATOM   4940 H HG21 . THR   B 1 112 ? 4.74646   -9.63407  16.38958  1.000 23.70785 ? 590 THR   A HG21 1 
ATOM   4941 H HG22 . THR   B 1 112 ? 5.59945   -10.01512 15.11690  1.000 23.70785 ? 590 THR   A HG22 1 
ATOM   4942 H HG23 . THR   B 1 112 ? 5.73184   -10.86655 16.43980  1.000 23.70785 ? 590 THR   A HG23 1 
ATOM   4943 N N    . TYR   B 1 113 ? 7.80905   -10.43316 13.73407  1.000 14.45311 ? 591 TYR   A N    1 
ATOM   4944 C CA   . TYR   B 1 113 ? 7.82368   -10.53439 12.28569  1.000 15.77381 ? 591 TYR   A CA   1 
ATOM   4945 C C    . TYR   B 1 113 ? 6.40326   -10.63239 11.73157  1.000 14.90959 ? 591 TYR   A C    1 
ATOM   4946 O O    . TYR   B 1 113 ? 5.56603   -11.37448 12.26031  1.000 15.54903 ? 591 TYR   A O    1 
ATOM   4947 C CB   . TYR   B 1 113 ? 8.61573   -11.76548 11.84520  1.000 18.12067 ? 591 TYR   A CB   1 
ATOM   4948 C CG   . TYR   B 1 113 ? 10.11183  -11.58610 12.00400  1.000 19.10472 ? 591 TYR   A CG   1 
ATOM   4949 C CD1  . TYR   B 1 113 ? 10.65887  -11.32573 13.24789  1.000 17.02144 ? 591 TYR   A CD1  1 
ATOM   4950 C CD2  . TYR   B 1 113 ? 10.94259  -11.64317 10.91079  1.000 21.33100 ? 591 TYR   A CD2  1 
ATOM   4951 C CE1  . TYR   B 1 113 ? 12.09323  -11.13616 13.37226  1.000 18.45624 ? 591 TYR   A CE1  1 
ATOM   4952 C CE2  . TYR   B 1 113 ? 12.29193  -11.47291 11.03430  1.000 19.66943 ? 591 TYR   A CE2  1 
ATOM   4953 C CZ   . TYR   B 1 113 ? 12.85096  -11.20433 12.26687  1.000 19.61162 ? 591 TYR   A CZ   1 
ATOM   4954 O OH   . TYR   B 1 113 ? 14.24109  -10.98787 12.34588  1.000 19.88980 ? 591 TYR   A OH   1 
ATOM   4955 H H    . TYR   B 1 113 ? 7.67307   -11.19312 14.11299  1.000 17.29775 ? 591 TYR   A H    1 
ATOM   4956 H HA   . TYR   B 1 113 ? 8.23669   -9.73631  11.92048  1.000 18.88259 ? 591 TYR   A HA   1 
ATOM   4957 H HB2  . TYR   B 1 113 ? 8.34515   -12.52486 12.38468  1.000 21.69881 ? 591 TYR   A HB2  1 
ATOM   4958 H HB3  . TYR   B 1 113 ? 8.43179   -11.94116 10.90914  1.000 21.69881 ? 591 TYR   A HB3  1 
ATOM   4959 H HD1  . TYR   B 1 113 ? 10.11228  -11.27254 13.99844  1.000 20.37974 ? 591 TYR   A HD1  1 
ATOM   4960 H HD2  . TYR   B 1 113 ? 10.57847  -11.80096 10.06971  1.000 25.55122 ? 591 TYR   A HD2  1 
ATOM   4961 H HE1  . TYR   B 1 113 ? 12.47925  -10.97070 14.20202  1.000 22.10150 ? 591 TYR   A HE1  1 
ATOM   4962 H HE2  . TYR   B 1 113 ? 12.83697  -11.53835 10.28361  1.000 23.55733 ? 591 TYR   A HE2  1 
ATOM   4963 H HH   . TYR   B 1 113 ? 14.45202  -10.75675 13.12542  1.000 23.82178 ? 591 TYR   A HH   1 
ATOM   4964 N N    . PHE   B 1 114 ? 6.15667   -9.91225  10.65744  1.000 15.61663 ? 592 PHE   A N    1 
ATOM   4965 C CA   . PHE   B 1 114 ? 4.87374   -9.88459  9.97216   1.000 16.37883 ? 592 PHE   A CA   1 
ATOM   4966 C C    . PHE   B 1 114 ? 5.08609   -10.00824 8.47038   1.000 16.48847 ? 592 PHE   A C    1 
ATOM   4967 O O    . PHE   B 1 114 ? 5.98095   -9.35733  7.90090   1.000 16.50850 ? 592 PHE   A O    1 
ATOM   4968 C CB   . PHE   B 1 114 ? 4.15338   -8.61241  10.27571  1.000 14.26130 ? 592 PHE   A CB   1 
ATOM   4969 C CG   . PHE   B 1 114 ? 3.87384   -8.41566  11.74090  1.000 15.22142 ? 592 PHE   A CG   1 
ATOM   4970 C CD1  . PHE   B 1 114 ? 2.79131   -9.00446  12.34817  1.000 12.86876 ? 592 PHE   A CD1  1 
ATOM   4971 C CD2  . PHE   B 1 114 ? 4.76546   -7.69539  12.54058  1.000 16.31902 ? 592 PHE   A CD2  1 
ATOM   4972 C CE1  . PHE   B 1 114 ? 2.55929   -8.83650  13.68326  1.000 14.65381 ? 592 PHE   A CE1  1 
ATOM   4973 C CE2  . PHE   B 1 114 ? 4.50584   -7.52499  13.88356  1.000 15.53749 ? 592 PHE   A CE2  1 
ATOM   4974 C CZ   . PHE   B 1 114 ? 3.41964   -8.11144  14.44966  1.000 18.33566 ? 592 PHE   A CZ   1 
ATOM   4975 H H    . PHE   B 1 114 ? 6.74265   -9.40488  10.28487  1.000 18.69397 ? 592 PHE   A H    1 
ATOM   4976 H HA   . PHE   B 1 114 ? 4.33024   -10.63571 10.25734  1.000 19.60861 ? 592 PHE   A HA   1 
ATOM   4977 H HB2  . PHE   B 1 114 ? 4.69507   -7.86652  9.97385   1.000 17.06758 ? 592 PHE   A HB2  1 
ATOM   4978 H HB3  . PHE   B 1 114 ? 3.30313   -8.61531  9.80884   1.000 17.06758 ? 592 PHE   A HB3  1 
ATOM   4979 H HD1  . PHE   B 1 114 ? 2.20867   -9.52445  11.84315  1.000 15.39653 ? 592 PHE   A HD1  1 
ATOM   4980 H HD2  . PHE   B 1 114 ? 5.53472   -7.33068  12.16624  1.000 19.53684 ? 592 PHE   A HD2  1 
ATOM   4981 H HE1  . PHE   B 1 114 ? 1.80705   -9.22073  14.07235  1.000 17.53859 ? 592 PHE   A HE1  1 
ATOM   4982 H HE2  . PHE   B 1 114 ? 5.07648   -7.00665  14.40375  1.000 18.59900 ? 592 PHE   A HE2  1 
ATOM   4983 H HZ   . PHE   B 1 114 ? 3.26340   -8.01765  15.36163  1.000 21.95681 ? 592 PHE   A HZ   1 
ATOM   4984 N N    . ALA   B 1 115 ? 4.21194   -10.79210 7.82358   1.000 15.26695 ? 593 ALA   A N    1 
ATOM   4985 C CA   . ALA   B 1 115 ? 4.36362   -11.13286 6.41694   1.000 15.83050 ? 593 ALA   A CA   1 
ATOM   4986 C C    . ALA   B 1 115 ? 3.41828   -10.33135 5.55279   1.000 16.72883 ? 593 ALA   A C    1 
ATOM   4987 O O    . ALA   B 1 115 ? 2.26103   -10.09282 5.93624   1.000 15.74364 ? 593 ALA   A O    1 
ATOM   4988 C CB   . ALA   B 1 115 ? 4.10062   -12.61894 6.16945   1.000 16.34820 ? 593 ALA   A CB   1 
ATOM   4989 H H    . ALA   B 1 115 ? 3.51591   -11.13949 8.19025   1.000 18.27436 ? 593 ALA   A H    1 
ATOM   4990 H HA   . ALA   B 1 115 ? 5.27476   -10.92113 6.16023   1.000 18.95062 ? 593 ALA   A HA   1 
ATOM   4991 H HB1  . ALA   B 1 115 ? 4.17277   -12.79840 5.21893   1.000 19.57185 ? 593 ALA   A HB1  1 
ATOM   4992 H HB2  . ALA   B 1 115 ? 4.75783   -13.14118 6.65549   1.000 19.57185 ? 593 ALA   A HB2  1 
ATOM   4993 H HB3  . ALA   B 1 115 ? 3.20834   -12.83784 6.48061   1.000 19.57185 ? 593 ALA   A HB3  1 
ATOM   4994 N N    . VAL   B 1 116 ? 3.92624   -9.87846  4.39857   1.000 15.43624 ? 594 VAL   A N    1 
ATOM   4995 C CA   . VAL   B 1 116 ? 3.06420   -9.25481  3.40667   1.000 16.66419 ? 594 VAL   A CA   1 
ATOM   4996 C C    . VAL   B 1 116 ? 2.04899   -10.25396 2.86889   1.000 16.56454 ? 594 VAL   A C    1 
ATOM   4997 O O    . VAL   B 1 116 ? 0.85238   -9.93045  2.70868   1.000 17.50222 ? 594 VAL   A O    1 
ATOM   4998 C CB   . VAL   B 1 116 ? 3.91034   -8.66238  2.27340   1.000 17.04519 ? 594 VAL   A CB   1 
ATOM   4999 C CG1  . VAL   B 1 116 ? 3.03876   -8.20370  1.11062   1.000 18.97391 ? 594 VAL   A CG1  1 
ATOM   5000 C CG2  . VAL   B 1 116 ? 4.75479   -7.45380  2.81422   1.000 18.74330 ? 594 VAL   A CG2  1 
ATOM   5001 H H    . VAL   B 1 116 ? 4.75546   -9.92264  4.17489   1.000 18.47751 ? 594 VAL   A H    1 
ATOM   5002 H HA   . VAL   B 1 116 ? 2.57649   -8.53516  3.83695   1.000 19.95104 ? 594 VAL   A HA   1 
ATOM   5003 H HB   . VAL   B 1 116 ? 4.50735   -9.35228  1.94400   1.000 20.40824 ? 594 VAL   A HB   1 
ATOM   5004 H HG11 . VAL   B 1 116 ? 3.55689   -7.61367  0.54114   1.000 22.72270 ? 594 VAL   A HG11 1 
ATOM   5005 H HG12 . VAL   B 1 116 ? 2.75022   -8.98061  0.60658   1.000 22.72270 ? 594 VAL   A HG12 1 
ATOM   5006 H HG13 . VAL   B 1 116 ? 2.26730   -7.73166  1.46122   1.000 22.72270 ? 594 VAL   A HG13 1 
ATOM   5007 H HG21 . VAL   B 1 116 ? 5.27279   -7.07897  2.08478   1.000 22.44597 ? 594 VAL   A HG21 1 
ATOM   5008 H HG22 . VAL   B 1 116 ? 4.15257   -6.78249  3.17138   1.000 22.44597 ? 594 VAL   A HG22 1 
ATOM   5009 H HG23 . VAL   B 1 116 ? 5.34846   -7.77084  3.51276   1.000 22.44597 ? 594 VAL   A HG23 1 
ATOM   5010 N N    . ASP   B 1 117 ? 2.49930   -11.46494 2.56831   1.000 17.80037 ? 595 ASP   A N    1 
ATOM   5011 C CA   . ASP   B 1 117 ? 1.64097   -12.50785 1.99546   1.000 18.27755 ? 595 ASP   A CA   1 
ATOM   5012 C C    . ASP   B 1 117 ? 1.22960   -13.54490 3.03237   1.000 17.56835 ? 595 ASP   A C    1 
ATOM   5013 O O    . ASP   B 1 117 ? 2.05901   -14.04469 3.78658   1.000 16.55647 ? 595 ASP   A O    1 
ATOM   5014 C CB   . ASP   B 1 117 ? 2.36795   -13.22957 0.85496   1.000 17.93762 ? 595 ASP   A CB   1 
ATOM   5015 C CG   . ASP   B 1 117 ? 2.62299   -12.36913 -0.31130  1.000 20.56152 ? 595 ASP   A CG   1 
ATOM   5016 O OD1  . ASP   B 1 117 ? 1.80726   -11.49302 -0.57667  1.000 22.42178 ? 595 ASP   A OD1  1 
ATOM   5017 O OD2  . ASP   B 1 117 ? 3.68904   -12.57049 -0.97726  1.000 24.13429 ? 595 ASP   A OD2  1 
ATOM   5018 H H    . ASP   B 1 117 ? 3.31304   -11.71644 2.68735   1.000 21.31446 ? 595 ASP   A H    1 
ATOM   5019 H HA   . ASP   B 1 117 ? 0.83488   -12.07593 1.67211   1.000 21.88707 ? 595 ASP   A HA   1 
ATOM   5020 H HB2  . ASP   B 1 117 ? 3.22355   -13.54966 1.18113   1.000 21.47916 ? 595 ASP   A HB2  1 
ATOM   5021 H HB3  . ASP   B 1 117 ? 1.82468   -13.97704 0.55991   1.000 21.47916 ? 595 ASP   A HB3  1 
ATOM   5022 N N    . ALA   B 1 118 ? -0.05493  -13.90445 3.03099   1.000 16.00098 ? 596 ALA   A N    1 
ATOM   5023 C CA   . ALA   B 1 118 ? -0.52248  -14.89051 3.98704   1.000 15.47834 ? 596 ALA   A CA   1 
ATOM   5024 C C    . ALA   B 1 118 ? 0.20797   -16.21589 3.78728   1.000 16.28667 ? 596 ALA   A C    1 
ATOM   5025 O O    . ALA   B 1 118 ? 0.46459   -16.93804 4.74421   1.000 17.57138 ? 596 ALA   A O    1 
ATOM   5026 C CB   . ALA   B 1 118 ? -2.04178  -15.09288 3.85587   1.000 16.56346 ? 596 ALA   A CB   1 
ATOM   5027 H H    . ALA   B 1 118 ? -0.65647  -13.59740 2.49857   1.000 19.15519 ? 596 ALA   A H    1 
ATOM   5028 H HA   . ALA   B 1 118 ? -0.35114  -14.56876 4.88594   1.000 18.52803 ? 596 ALA   A HA   1 
ATOM   5029 H HB1  . ALA   B 1 118 ? -2.32946  -15.75413 4.50462   1.000 19.83017 ? 596 ALA   A HB1  1 
ATOM   5030 H HB2  . ALA   B 1 118 ? -2.48852  -14.24844 4.02392   1.000 19.83017 ? 596 ALA   A HB2  1 
ATOM   5031 H HB3  . ALA   B 1 118 ? -2.24304  -15.40070 2.95830   1.000 19.83017 ? 596 ALA   A HB3  1 
ATOM   5032 N N    . SER   B 1 119 ? 0.60267   -16.51093 2.55059   1.000 16.55945 ? 597 SER   A N    1 
ATOM   5033 C CA   . SER   B 1 119 ? 1.25182   -17.78608 2.27634   1.000 17.52868 ? 597 SER   A CA   1 
ATOM   5034 C C    . SER   B 1 119 ? 2.56770   -17.92872 3.04038   1.000 17.80649 ? 597 SER   A C    1 
ATOM   5035 O O    . SER   B 1 119 ? 2.97159   -19.03883 3.37383   1.000 18.59398 ? 597 SER   A O    1 
ATOM   5036 C CB   . SER   B 1 119 ? 1.49312   -17.89794 0.78252   1.000 19.47112 ? 597 SER   A CB   1 
ATOM   5037 O OG   . SER   B 1 119 ? 2.24917   -16.81467 0.28796   1.000 18.73941 ? 597 SER   A OG   1 
ATOM   5038 H H    . SER   B 1 119 ? 0.50777   -15.99920 1.86595   1.000 19.82535 ? 597 SER   A H    1 
ATOM   5039 H HA   . SER   B 1 119 ? 0.67353   -18.51200 2.55832   1.000 20.98843 ? 597 SER   A HA   1 
ATOM   5040 H HB2  . SER   B 1 119 ? 1.97558   -18.72069 0.60585   1.000 23.31936 ? 597 SER   A HB2  1 
ATOM   5041 H HB3  . SER   B 1 119 ? 0.63585   -17.91210 0.32889   1.000 23.31936 ? 597 SER   A HB3  1 
ATOM   5042 H HG   . SER   B 1 119 ? 2.37193   -16.90346 -0.53826  1.000 22.44130 ? 597 SER   A HG   1 
ATOM   5043 N N    . TYR   B 1 120 ? 3.24921   -16.80597 3.33095   1.000 18.15475 ? 598 TYR   A N    1 
ATOM   5044 C CA   . TYR   B 1 120 ? 4.48002   -16.89385 4.11608   1.000 20.48025 ? 598 TYR   A CA   1 
ATOM   5045 C C    . TYR   B 1 120 ? 4.16671   -17.24080 5.56245   1.000 18.86918 ? 598 TYR   A C    1 
ATOM   5046 O O    . TYR   B 1 120 ? 4.76459   -18.14315 6.13851   1.000 19.68365 ? 598 TYR   A O    1 
ATOM   5047 C CB   . TYR   B 1 120 ? 5.23232   -15.58468 4.02670   1.000 21.15865 ? 598 TYR   A CB   1 
ATOM   5048 C CG   . TYR   B 1 120 ? 6.70354   -15.71679 4.36205   1.000 28.27118 ? 598 TYR   A CG   1 
ATOM   5049 C CD1  . TYR   B 1 120 ? 7.62252   -16.07062 3.38600   1.000 36.43297 ? 598 TYR   A CD1  1 
ATOM   5050 C CD2  . TYR   B 1 120 ? 7.16490   -15.50640 5.65303   1.000 33.60141 ? 598 TYR   A CD2  1 
ATOM   5051 C CE1  . TYR   B 1 120 ? 8.97448   -16.19140 3.68951   1.000 41.09526 ? 598 TYR   A CE1  1 
ATOM   5052 C CE2  . TYR   B 1 120 ? 8.50804   -15.61643 5.95970   1.000 35.73292 ? 598 TYR   A CE2  1 
ATOM   5053 C CZ   . TYR   B 1 120 ? 9.40385   -15.95882 4.97598   1.000 40.36161 ? 598 TYR   A CZ   1 
ATOM   5054 O OH   . TYR   B 1 120 ? 10.74110  -16.07853 5.28824   1.000 45.16607 ? 598 TYR   A OH   1 
ATOM   5055 H H    . TYR   B 1 120 ? 3.02364   -16.01145 3.09125   1.000 21.73971 ? 598 TYR   A H    1 
ATOM   5056 H HA   . TYR   B 1 120 ? 5.04733   -17.59229 3.75381   1.000 24.53032 ? 598 TYR   A HA   1 
ATOM   5057 H HB2  . TYR   B 1 120 ? 5.16219   -15.24356 3.12137   1.000 25.34439 ? 598 TYR   A HB2  1 
ATOM   5058 H HB3  . TYR   B 1 120 ? 4.83971   -14.95386 4.65026   1.000 25.34439 ? 598 TYR   A HB3  1 
ATOM   5059 H HD1  . TYR   B 1 120 ? 7.33118   -16.22924 2.51717   1.000 43.67358 ? 598 TYR   A HD1  1 
ATOM   5060 H HD2  . TYR   B 1 120 ? 6.55964   -15.28738 6.32429   1.000 40.27570 ? 598 TYR   A HD2  1 
ATOM   5061 H HE1  . TYR   B 1 120 ? 9.58381   -16.42763 3.02783   1.000 49.26833 ? 598 TYR   A HE1  1 
ATOM   5062 H HE2  . TYR   B 1 120 ? 8.80384   -15.45953 6.82734   1.000 42.83352 ? 598 TYR   A HE2  1 
ATOM   5063 H HH   . TYR   B 1 120 ? 10.86241  -15.90897 6.10196   1.000 54.15330 ? 598 TYR   A HH   1 
ATOM   5064 N N    . SER   B 1 121 ? 3.15946   -16.58519 6.14235   1.000 17.40663 ? 599 SER   A N    1 
ATOM   5065 C CA   . SER   B 1 121 ? 2.75604   -16.92235 7.50341   1.000 18.17742 ? 599 SER   A CA   1 
ATOM   5066 C C    . SER   B 1 121 ? 2.11967   -18.30213 7.58628   1.000 17.60099 ? 599 SER   A C    1 
ATOM   5067 O O    . SER   B 1 121 ? 1.98873   -18.85860 8.68256   1.000 16.56825 ? 599 SER   A O    1 
ATOM   5068 C CB   . SER   B 1 121 ? 1.75706   -15.86769 8.03113   1.000 17.10063 ? 599 SER   A CB   1 
ATOM   5069 O OG   . SER   B 1 121 ? 2.31803   -14.57521 8.07719   1.000 16.72091 ? 599 SER   A OG   1 
ATOM   5070 H H    . SER   B 1 121 ? 2.70416   -15.95459 5.77541   1.000 20.84197 ? 599 SER   A H    1 
ATOM   5071 H HA   . SER   B 1 121 ? 3.54170   -16.91354 8.07222   1.000 21.76692 ? 599 SER   A HA   1 
ATOM   5072 H HB2  . SER   B 1 121 ? 0.98576   -15.84996 7.44318   1.000 20.47477 ? 599 SER   A HB2  1 
ATOM   5073 H HB3  . SER   B 1 121 ? 1.48519   -16.11962 8.92752   1.000 20.47477 ? 599 SER   A HB3  1 
ATOM   5074 H HG   . SER   B 1 121 ? 2.98041   -14.56775 8.59371   1.000 20.01911 ? 599 SER   A HG   1 
ATOM   5075 N N    . ALA   B 1 122 ? 1.70096   -18.86404 6.45294   1.000 17.97331 ? 600 ALA   A N    1 
ATOM   5076 C CA   . ALA   B 1 122 ? 1.05582   -20.17242 6.45613   1.000 17.78167 ? 600 ALA   A CA   1 
ATOM   5077 C C    . ALA   B 1 122 ? 2.05688   -21.33231 6.55293   1.000 19.16420 ? 600 ALA   A C    1 
ATOM   5078 O O    . ALA   B 1 122 ? 1.64657   -22.47837 6.70977   1.000 20.05803 ? 600 ALA   A O    1 
ATOM   5079 C CB   . ALA   B 1 122 ? 0.22054   -20.32183 5.17684   1.000 17.62694 ? 600 ALA   A CB   1 
ATOM   5080 H H    . ALA   B 1 122 ? 1.77917   -18.50841 5.67383   1.000 21.52198 ? 600 ALA   A H    1 
ATOM   5081 H HA   . ALA   B 1 122 ? 0.46378   -20.23502 7.22194   1.000 21.29202 ? 600 ALA   A HA   1 
ATOM   5082 H HB1  . ALA   B 1 122 ? -0.20999  -21.19104 5.18051   1.000 21.10634 ? 600 ALA   A HB1  1 
ATOM   5083 H HB2  . ALA   B 1 122 ? -0.44956  -19.62089 5.15354   1.000 21.10634 ? 600 ALA   A HB2  1 
ATOM   5084 H HB3  . ALA   B 1 122 ? 0.80568   -20.24577 4.40695   1.000 21.10634 ? 600 ALA   A HB3  1 
ATOM   5085 N N    . LYS   B 1 123 ? 3.35720   -21.05681 6.48269   1.000 20.57333 ? 601 LYS   A N    1 
ATOM   5086 C CA   . LYS   B 1 123 ? 4.34134   -22.11272 6.67591   1.000 21.40848 ? 601 LYS   A CA   1 
ATOM   5087 C C    . LYS   B 1 123 ? 4.15520   -22.77791 8.03023   1.000 20.40377 ? 601 LYS   A C    1 
ATOM   5088 O O    . LYS   B 1 123 ? 3.83840   -22.12288 9.03512   1.000 19.92725 ? 601 LYS   A O    1 
ATOM   5089 C CB   . LYS   B 1 123 ? 5.76114   -21.54633 6.53689   1.000 22.64339 ? 601 LYS   A CB   1 
ATOM   5090 C CG   . LYS   B 1 123 ? 6.02172   -20.90481 5.18388   1.000 26.97624 ? 601 LYS   A CG   1 
ATOM   5091 C CD   . LYS   B 1 123 ? 7.43750   -20.30842 5.06632   1.000 31.52258 ? 601 LYS   A CD   1 
ATOM   5092 C CE   . LYS   B 1 123 ? 8.44062   -21.33425 4.61406   1.000 41.02139 ? 601 LYS   A CE   1 
ATOM   5093 N NZ   . LYS   B 1 123 ? 9.60149   -20.68058 3.93119   1.000 44.85968 ? 601 LYS   A NZ   1 
ATOM   5094 H H    . LYS   B 1 123 ? 3.68881   -20.27877 6.32686   1.000 24.64201 ? 601 LYS   A H    1 
ATOM   5095 H HA   . LYS   B 1 123 ? 4.22534   -22.79263 5.99388   1.000 25.64419 ? 601 LYS   A HA   1 
ATOM   5096 H HB2  . LYS   B 1 123 ? 5.89725   -20.87003 7.21879   1.000 27.12609 ? 601 LYS   A HB2  1 
ATOM   5097 H HB3  . LYS   B 1 123 ? 6.39934   -22.26754 6.65287   1.000 27.12609 ? 601 LYS   A HB3  1 
ATOM   5098 H HG2  . LYS   B 1 123 ? 5.92173   -21.57643 4.49118   1.000 32.32550 ? 601 LYS   A HG2  1 
ATOM   5099 H HG3  . LYS   B 1 123 ? 5.38293   -20.18805 5.04570   1.000 32.32550 ? 601 LYS   A HG3  1 
ATOM   5100 H HD2  . LYS   B 1 123 ? 7.42805   -19.58683 4.41815   1.000 37.78112 ? 601 LYS   A HD2  1 
ATOM   5101 H HD3  . LYS   B 1 123 ? 7.71631   -19.97262 5.93258   1.000 37.78112 ? 601 LYS   A HD3  1 
ATOM   5102 H HE2  . LYS   B 1 123 ? 8.77194   -21.82373 5.38318   1.000 49.17968 ? 601 LYS   A HE2  1 
ATOM   5103 H HE3  . LYS   B 1 123 ? 8.01963   -21.94455 3.98860   1.000 49.17968 ? 601 LYS   A HE3  1 
ATOM   5104 H HZ1  . LYS   B 1 123 ? 10.18894  -21.29704 3.67240   1.000 53.78563 ? 601 LYS   A HZ1  1 
ATOM   5105 H HZ2  . LYS   B 1 123 ? 9.32044   -20.23125 3.21620   1.000 53.78563 ? 601 LYS   A HZ2  1 
ATOM   5106 H HZ3  . LYS   B 1 123 ? 10.00319  -20.11470 4.48843   1.000 53.78563 ? 601 LYS   A HZ3  1 
ATOM   5107 N N    . ASP   B 1 124 ? 4.37894   -24.10840 8.06208   1.000 21.74681 ? 602 ASP   A N    1 
ATOM   5108 C CA   . ASP   B 1 124 ? 4.19352   -24.85517 9.29186   1.000 22.83457 ? 602 ASP   A CA   1 
ATOM   5109 C C    . ASP   B 1 124 ? 5.16610   -24.43907 10.39308  1.000 23.61308 ? 602 ASP   A C    1 
ATOM   5110 O O    . ASP   B 1 124 ? 4.86924   -24.67536 11.57602  1.000 24.58298 ? 602 ASP   A O    1 
ATOM   5111 C CB   . ASP   B 1 124 ? 4.36204   -26.36069 9.03357   1.000 26.96196 ? 602 ASP   A CB   1 
ATOM   5112 C CG   . ASP   B 1 124 ? 3.13112   -26.99375 8.40974   1.000 30.54470 ? 602 ASP   A CG   1 
ATOM   5113 O OD1  . ASP   B 1 124 ? 2.07059   -26.32394 8.26462   1.000 25.90050 ? 602 ASP   A OD1  1 
ATOM   5114 O OD2  . ASP   B 1 124 ? 3.22114   -28.18685 8.06491   1.000 29.67683 ? 602 ASP   A OD2  1 
ATOM   5115 H H    . ASP   B 1 124 ? 4.63372   -24.58100 7.39026   1.000 26.05019 ? 602 ASP   A H    1 
ATOM   5116 H HA   . ASP   B 1 124 ? 3.28978   -24.68687 9.60143   1.000 27.35550 ? 602 ASP   A HA   1 
ATOM   5117 H HB2  . ASP   B 1 124 ? 5.10767   -26.49554 8.42797   1.000 32.30837 ? 602 ASP   A HB2  1 
ATOM   5118 H HB3  . ASP   B 1 124 ? 4.53429   -26.80828 9.87671   1.000 32.30837 ? 602 ASP   A HB3  1 
ATOM   5119 N N    . THR   B 1 125 ? 6.31894   -23.86460 10.03391  1.000 23.10762 ? 603 THR   A N    1 
ATOM   5120 C CA   . THR   B 1 125 ? 7.25106   -23.36404 11.04738  1.000 23.97735 ? 603 THR   A CA   1 
ATOM   5121 C C    . THR   B 1 125 ? 6.69712   -22.15808 11.80493  1.000 27.46904 ? 603 THR   A C    1 
ATOM   5122 O O    . THR   B 1 125 ? 7.14937   -21.87327 12.91954  1.000 27.12315 ? 603 THR   A O    1 
ATOM   5123 C CB   . THR   B 1 125 ? 8.58125   -22.99389 10.39980  1.000 24.69658 ? 603 THR   A CB   1 
ATOM   5124 O OG1  . THR   B 1 125 ? 8.35099   -22.08909 9.32616   1.000 30.16056 ? 603 THR   A OG1  1 
ATOM   5125 C CG2  . THR   B 1 125 ? 9.26106   -24.23432 9.85153   1.000 31.88172 ? 603 THR   A CG2  1 
ATOM   5126 H H    . THR   B 1 125 ? 6.58077   -23.75433 9.22220   1.000 27.68316 ? 603 THR   A H    1 
ATOM   5127 H HA   . THR   B 1 125 ? 7.41382   -24.07225 11.68992  1.000 28.72684 ? 603 THR   A HA   1 
ATOM   5128 H HB   . THR   B 1 125 ? 9.15971   -22.58188 11.06050  1.000 29.58991 ? 603 THR   A HB   1 
ATOM   5129 H HG1  . THR   B 1 125 ? 9.07987   -21.88206 8.96358   1.000 36.14668 ? 603 THR   A HG1  1 
ATOM   5130 H HG21 . THR   B 1 125 ? 10.11463  -23.99755 9.45624   1.000 38.21208 ? 603 THR   A HG21 1 
ATOM   5131 H HG22 . THR   B 1 125 ? 9.41130   -24.87336 10.56565  1.000 38.21208 ? 603 THR   A HG22 1 
ATOM   5132 H HG23 . THR   B 1 125 ? 8.70326   -24.64586 9.17301   1.000 38.21208 ? 603 THR   A HG23 1 
ATOM   5133 N N    . TYR   B 1 126 ? 5.71057   -21.46093 11.23392  1.000 23.42040 ? 604 TYR   A N    1 
ATOM   5134 C CA   . TYR   B 1 126 ? 5.11474   -20.27850 11.85592  1.000 22.11948 ? 604 TYR   A CA   1 
ATOM   5135 C C    . TYR   B 1 126 ? 3.73329   -20.61915 12.40386  1.000 21.57061 ? 604 TYR   A C    1 
ATOM   5136 O O    . TYR   B 1 126 ? 3.53384   -20.63973 13.62429  1.000 21.91520 ? 604 TYR   A O    1 
ATOM   5137 C CB   . TYR   B 1 126 ? 5.06613   -19.14503 10.83499  1.000 21.36008 ? 604 TYR   A CB   1 
ATOM   5138 C CG   . TYR   B 1 126 ? 6.40052   -18.79286 10.23736  1.000 22.20235 ? 604 TYR   A CG   1 
ATOM   5139 C CD1  . TYR   B 1 126 ? 7.56565   -18.92722 10.96483  1.000 28.64487 ? 604 TYR   A CD1  1 
ATOM   5140 C CD2  . TYR   B 1 126 ? 6.50355   -18.32297 8.94528   1.000 23.85165 ? 604 TYR   A CD2  1 
ATOM   5141 C CE1  . TYR   B 1 126 ? 8.79770   -18.59851 10.41034  1.000 29.93358 ? 604 TYR   A CE1  1 
ATOM   5142 C CE2  . TYR   B 1 126 ? 7.69916   -18.00758 8.39114   1.000 26.87424 ? 604 TYR   A CE2  1 
ATOM   5143 C CZ   . TYR   B 1 126 ? 8.85182   -18.14726 9.12704   1.000 27.83030 ? 604 TYR   A CZ   1 
ATOM   5144 O OH   . TYR   B 1 126 ? 10.04925  -17.80864 8.57986   1.000 29.78998 ? 604 TYR   A OH   1 
ATOM   5145 H H    . TYR   B 1 126 ? 5.36404   -21.65815 10.47194  1.000 28.05849 ? 604 TYR   A H    1 
ATOM   5146 H HA   . TYR   B 1 126 ? 5.65441   -19.98189 12.60537  1.000 26.49739 ? 604 TYR   A HA   1 
ATOM   5147 H HB2  . TYR   B 1 126 ? 4.47897   -19.40723 10.10877  1.000 25.58611 ? 604 TYR   A HB2  1 
ATOM   5148 H HB3  . TYR   B 1 126 ? 4.72042   -18.35032 11.27069  1.000 25.58611 ? 604 TYR   A HB3  1 
ATOM   5149 H HD1  . TYR   B 1 126 ? 7.52615   -19.24231 11.83893  1.000 34.32786 ? 604 TYR   A HD1  1 
ATOM   5150 H HD2  . TYR   B 1 126 ? 5.73006   -18.21948 8.43941   1.000 28.57600 ? 604 TYR   A HD2  1 
ATOM   5151 H HE1  . TYR   B 1 126 ? 9.57661   -18.68600 10.91088  1.000 35.87431 ? 604 TYR   A HE1  1 
ATOM   5152 H HE2  . TYR   B 1 126 ? 7.73985   -17.69745 7.51532   1.000 32.20311 ? 604 TYR   A HE2  1 
ATOM   5153 H HH   . TYR   B 1 126 ? 9.93996   -17.54599 7.78950   1.000 35.70199 ? 604 TYR   A HH   1 
ATOM   5154 N N    . SER   B 1 127 ? 2.75894   -20.88399 11.53284  1.000 20.02600 ? 605 SER   A N    1 
ATOM   5155 C CA   . SER   B 1 127 ? 1.42493   -21.30134 11.96842  1.000 19.89656 ? 605 SER   A CA   1 
ATOM   5156 C C    . SER   B 1 127 ? 1.44649   -22.81465 12.18832  1.000 22.27393 ? 605 SER   A C    1 
ATOM   5157 O O    . SER   B 1 127 ? 0.86719   -23.60495 11.43916  1.000 20.12387 ? 605 SER   A O    1 
ATOM   5158 C CB   . SER   B 1 127 ? 0.36720   -20.88122 10.96491  1.000 19.90725 ? 605 SER   A CB   1 
ATOM   5159 O OG   . SER   B 1 127 ? 0.73139   -21.17006 9.63241   1.000 18.07084 ? 605 SER   A OG   1 
ATOM   5160 H H    . SER   B 1 127 ? 2.84609   -20.82896 10.67904  1.000 23.98522 ? 605 SER   A H    1 
ATOM   5161 H HA   . SER   B 1 127 ? 1.20810   -20.86708 12.80824  1.000 23.82988 ? 605 SER   A HA   1 
ATOM   5162 H HB2  . SER   B 1 127 ? -0.45516  -21.35363 11.16853  1.000 23.84271 ? 605 SER   A HB2  1 
ATOM   5163 H HB3  . SER   B 1 127 ? 0.22896   -19.92453 11.04573  1.000 23.84271 ? 605 SER   A HB3  1 
ATOM   5164 H HG   . SER   B 1 127 ? 1.38368   -20.69309 9.40302   1.000 21.63903 ? 605 SER   A HG   1 
ATOM   5165 N N    . LYS   B 1 128 ? 2.11756   -23.21552 13.26195  1.000 23.85802 ? 606 LYS   A N    1 
ATOM   5166 C CA   . LYS   B 1 128 ? 2.31646   -24.64088 13.52409  1.000 24.35943 ? 606 LYS   A CA   1 
ATOM   5167 C C    . LYS   B 1 128 ? 0.97620   -25.35552 13.65470  1.000 25.46537 ? 606 LYS   A C    1 
ATOM   5168 O O    . LYS   B 1 128 ? 0.11865   -24.93110 14.44867  1.000 24.52227 ? 606 LYS   A O    1 
ATOM   5169 C CB   . LYS   B 1 128 ? 3.12987   -24.82681 14.80740  1.000 26.50940 ? 606 LYS   A CB   1 
ATOM   5170 C CG   . LYS   B 1 128 ? 4.55235   -24.30454 14.73835  1.000 38.90227 ? 606 LYS   A CG   1 
ATOM   5171 C CD   . LYS   B 1 128 ? 5.35632   -24.71933 15.96586  1.000 49.44679 ? 606 LYS   A CD   1 
ATOM   5172 C CE   . LYS   B 1 128 ? 6.84302   -24.43456 15.77113  1.000 59.88416 ? 606 LYS   A CE   1 
ATOM   5173 N NZ   . LYS   B 1 128 ? 7.68989   -25.23797 16.70735  1.000 72.47715 ? 606 LYS   A NZ   1 
ATOM   5174 H H    . LYS   B 1 128 ? 2.46480   -22.69157 13.84890  1.000 28.58364 ? 606 LYS   A H    1 
ATOM   5175 H HA   . LYS   B 1 128 ? 2.79886   -25.03670 12.78145  1.000 29.18533 ? 606 LYS   A HA   1 
ATOM   5176 H HB2  . LYS   B 1 128 ? 2.68091   -24.35686 15.52745  1.000 31.76530 ? 606 LYS   A HB2  1 
ATOM   5177 H HB3  . LYS   B 1 128 ? 3.17627   -25.77470 15.00805  1.000 31.76530 ? 606 LYS   A HB3  1 
ATOM   5178 H HG2  . LYS   B 1 128 ? 4.98955   -24.66459 13.95087  1.000 46.63674 ? 606 LYS   A HG2  1 
ATOM   5179 H HG3  . LYS   B 1 128 ? 4.53776   -23.33558 14.69587  1.000 46.63674 ? 606 LYS   A HG3  1 
ATOM   5180 H HD2  . LYS   B 1 128 ? 5.04719   -24.22016 16.73798  1.000 59.29017 ? 606 LYS   A HD2  1 
ATOM   5181 H HD3  . LYS   B 1 128 ? 5.24393   -25.67054 16.11903  1.000 59.29017 ? 606 LYS   A HD3  1 
ATOM   5182 H HE2  . LYS   B 1 128 ? 7.09589   -24.66106 14.86247  1.000 71.81501 ? 606 LYS   A HE2  1 
ATOM   5183 H HE3  . LYS   B 1 128 ? 7.01334   -23.49438 15.93832  1.000 71.81501 ? 606 LYS   A HE3  1 
ATOM   5184 H HZ1  . LYS   B 1 128 ? 8.55032   -25.05421 16.57325  1.000 86.92660 ? 606 LYS   A HZ1  1 
ATOM   5185 H HZ2  . LYS   B 1 128 ? 7.48086   -25.04306 17.55021  1.000 86.92660 ? 606 LYS   A HZ2  1 
ATOM   5186 H HZ3  . LYS   B 1 128 ? 7.55530   -26.10693 16.56992  1.000 86.92660 ? 606 LYS   A HZ3  1 
ATOM   5187 N N    . PRO   B 1 129 ? 0.75241   -26.44011 12.91730  1.000 27.24570 ? 607 PRO   A N    1 
ATOM   5188 C CA   . PRO   B 1 129 ? -0.49422  -27.19367 13.10258  1.000 26.81690 ? 607 PRO   A CA   1 
ATOM   5189 C C    . PRO   B 1 129 ? -0.58383  -27.75747 14.51490  1.000 30.20266 ? 607 PRO   A C    1 
ATOM   5190 O O    . PRO   B 1 129 ? 0.39188   -28.26959 15.05053  1.000 31.47934 ? 607 PRO   A O    1 
ATOM   5191 C CB   . PRO   B 1 129 ? -0.39290  -28.31302 12.05741  1.000 30.57840 ? 607 PRO   A CB   1 
ATOM   5192 C CG   . PRO   B 1 129 ? 0.68258   -27.93443 11.13733  1.000 29.45927 ? 607 PRO   A CG   1 
ATOM   5193 C CD   . PRO   B 1 129 ? 1.62846   -27.05072 11.90212  1.000 30.34009 ? 607 PRO   A CD   1 
ATOM   5194 H HA   . PRO   B 1 129 ? -1.26749  -26.63879 12.91531  1.000 32.13430 ? 607 PRO   A HA   1 
ATOM   5195 H HB2  . PRO   B 1 129 ? -0.18377  -29.15042 12.50004  1.000 36.64810 ? 607 PRO   A HB2  1 
ATOM   5196 H HB3  . PRO   B 1 129 ? -1.23572  -28.38976 11.58342  1.000 36.64810 ? 607 PRO   A HB3  1 
ATOM   5197 H HG2  . PRO   B 1 129 ? 1.13897   -28.73306 10.82946  1.000 35.30514 ? 607 PRO   A HG2  1 
ATOM   5198 H HG3  . PRO   B 1 129 ? 0.30666   -27.45526 10.38236  1.000 35.30514 ? 607 PRO   A HG3  1 
ATOM   5199 H HD2  . PRO   B 1 129 ? 2.33171   -27.57293 12.31881  1.000 36.36212 ? 607 PRO   A HD2  1 
ATOM   5200 H HD3  . PRO   B 1 129 ? 2.01539   -26.37408 11.32477  1.000 36.36212 ? 607 PRO   A HD3  1 
ATOM   5201 N N    . ASP   B 1 130 ? -1.76660  -27.67348 15.11026  1.000 31.20609 ? 608 ASP   A N    1 
ATOM   5202 C CA   . ASP   B 1 130 ? -1.95663  -28.16672 16.46350  1.000 35.63982 ? 608 ASP   A CA   1 
ATOM   5203 C C    . ASP   B 1 130 ? -2.33103  -29.64895 16.40197  1.000 40.78434 ? 608 ASP   A C    1 
ATOM   5204 O O    . ASP   B 1 130 ? -2.37505  -30.26513 15.33206  1.000 38.33267 ? 608 ASP   A O    1 
ATOM   5205 C CB   . ASP   B 1 130 ? -3.00563  -27.33478 17.20688  1.000 35.23151 ? 608 ASP   A CB   1 
ATOM   5206 C CG   . ASP   B 1 130 ? -4.41363  -27.48227 16.62606  1.000 38.79225 ? 608 ASP   A CG   1 
ATOM   5207 O OD1  . ASP   B 1 130 ? -4.65309  -28.37489 15.78262  1.000 35.62137 ? 608 ASP   A OD1  1 
ATOM   5208 O OD2  . ASP   B 1 130 ? -5.29065  -26.67597 17.03089  1.000 37.16054 ? 608 ASP   A OD2  1 
ATOM   5209 H H    . ASP   B 1 130 ? -2.47123  -27.33578 14.75100  1.000 37.40132 ? 608 ASP   A H    1 
ATOM   5210 H HA   . ASP   B 1 130 ? -1.12864  -28.07689 16.96076  1.000 42.72180 ? 608 ASP   A HA   1 
ATOM   5211 H HB2  . ASP   B 1 130 ? -3.03405  -27.61986 18.13361  1.000 42.23183 ? 608 ASP   A HB2  1 
ATOM   5212 H HB3  . ASP   B 1 130 ? -2.75847  -26.39821 17.15531  1.000 42.23183 ? 608 ASP   A HB3  1 
ATOM   5213 N N    . SER   B 1 131 ? -2.59489  -30.23512 17.57042  1.000 47.28385 ? 609 SER   A N    1 
ATOM   5214 C CA   . SER   B 1 131 ? -2.87433  -31.66305 17.64360  1.000 48.37912 ? 609 SER   A CA   1 
ATOM   5215 C C    . SER   B 1 131 ? -4.06324  -32.08205 16.79285  1.000 48.44692 ? 609 SER   A C    1 
ATOM   5216 O O    . SER   B 1 131 ? -4.25523  -33.28299 16.59439  1.000 48.79674 ? 609 SER   A O    1 
ATOM   5217 C CB   . SER   B 1 131 ? -3.11435  -32.06877 19.10126  1.000 49.80581 ? 609 SER   A CB   1 
ATOM   5218 O OG   . SER   B 1 131 ? -4.14943  -31.30440 19.68830  1.000 54.01952 ? 609 SER   A OG   1 
ATOM   5219 H H    . SER   B 1 131 ? -2.61739  -29.82885 18.32808  1.000 56.69463 ? 609 SER   A H    1 
ATOM   5220 H HA   . SER   B 1 131 ? -2.09839  -32.14459 17.31660  1.000 58.00896 ? 609 SER   A HA   1 
ATOM   5221 H HB2  . SER   B 1 131 ? -3.36307  -33.00595 19.12856  1.000 59.72099 ? 609 SER   A HB2  1 
ATOM   5222 H HB3  . SER   B 1 131 ? -2.29702  -31.92766 19.60422  1.000 59.72099 ? 609 SER   A HB3  1 
ATOM   5223 H HG   . SER   B 1 131 ? -4.26410  -31.54084 20.48614  1.000 64.77743 ? 609 SER   A HG   1 
ATOM   5224 N N    . ASN   B 1 132 ? -4.85989  -31.13508 16.29340  1.000 47.83752 ? 610 ASN   A N    1 
ATOM   5225 C CA   . ASN   B 1 132 ? -5.98686  -31.43090 15.42114  1.000 42.39690 ? 610 ASN   A CA   1 
ATOM   5226 C C    . ASN   B 1 132 ? -5.75686  -30.98032 13.98410  1.000 40.35758 ? 610 ASN   A C    1 
ATOM   5227 O O    . ASN   B 1 132 ? -6.68841  -31.02740 13.17592  1.000 40.02068 ? 610 ASN   A O    1 
ATOM   5228 C CB   . ASN   B 1 132 ? -7.25901  -30.77424 15.96440  1.000 47.03542 ? 610 ASN   A CB   1 
ATOM   5229 C CG   . ASN   B 1 132 ? -7.76347  -31.44519 17.22688  1.000 49.77203 ? 610 ASN   A CG   1 
ATOM   5230 O OD1  . ASN   B 1 132 ? -7.84375  -30.82506 18.28218  1.000 48.32938 ? 610 ASN   A OD1  1 
ATOM   5231 N ND2  . ASN   B 1 132 ? -8.10171  -32.72725 17.11944  1.000 54.85716 ? 610 ASN   A ND2  1 
ATOM   5232 H H    . ASN   B 1 132 ? -4.76172  -30.29552 16.45184  1.000 57.35904 ? 610 ASN   A H    1 
ATOM   5233 H HA   . ASN   B 1 132 ? -6.11615  -32.39221 15.41340  1.000 50.83030 ? 610 ASN   A HA   1 
ATOM   5234 H HB2  . ASN   B 1 132 ? -7.07295  -29.84493 16.17095  1.000 56.39652 ? 610 ASN   A HB2  1 
ATOM   5235 H HB3  . ASN   B 1 132 ? -7.95704  -30.83161 15.29331  1.000 56.39652 ? 610 ASN   A HB3  1 
ATOM   5236 H HD21 . ASN   B 1 132 ? -8.39380  -33.15395 17.80663  1.000 65.78261 ? 610 ASN   A HD21 1 
ATOM   5237 H HD22 . ASN   B 1 132 ? -8.02830  -33.12938 16.36281  1.000 65.78261 ? 610 ASN   A HD22 1 
ATOM   5238 N N    . GLY   B 1 133 ? -4.54588  -30.53269 13.64921  1.000 39.37709 ? 611 GLY   A N    1 
ATOM   5239 C CA   . GLY   B 1 133 ? -4.25197  -30.03629 12.31967  1.000 32.58927 ? 611 GLY   A CA   1 
ATOM   5240 C C    . GLY   B 1 133 ? -4.67259  -28.59898 12.06797  1.000 31.83226 ? 611 GLY   A C    1 
ATOM   5241 O O    . GLY   B 1 133 ? -4.52545  -28.10642 10.94302  1.000 30.57178 ? 611 GLY   A O    1 
ATOM   5242 H H    . GLY   B 1 133 ? -3.87428  -30.50883 14.18585  1.000 47.20652 ? 611 GLY   A H    1 
ATOM   5243 H HA2  . GLY   B 1 133 ? -3.29530  -30.09512 12.17061  1.000 39.06114 ? 611 GLY   A HA2  1 
ATOM   5244 H HA3  . GLY   B 1 133 ? -4.70759  -30.59584 11.67144  1.000 39.06114 ? 611 GLY   A HA3  1 
ATOM   5245 N N    . ARG   B 1 134 ? -5.19607  -27.91603 13.06589  1.000 32.46008 ? 612 ARG   A N    1 
ATOM   5246 C CA   . ARG   B 1 134 ? -5.63868  -26.54535 12.87741  1.000 30.29522 ? 612 ARG   A CA   1 
ATOM   5247 C C    . ARG   B 1 134 ? -4.43833  -25.60376 12.91397  1.000 26.63229 ? 612 ARG   A C    1 
ATOM   5248 O O    . ARG   B 1 134 ? -3.52386  -25.77882 13.72090  1.000 24.89475 ? 612 ARG   A O    1 
ATOM   5249 C CB   . ARG   B 1 134 ? -6.64388  -26.16389 13.95579  1.000 29.47415 ? 612 ARG   A CB   1 
ATOM   5250 C CG   . ARG   B 1 134 ? -7.86613  -27.06278 14.02444  1.000 38.26858 ? 612 ARG   A CG   1 
ATOM   5251 C CD   . ARG   B 1 134 ? -9.05541  -26.30034 14.60262  1.000 49.03193 ? 612 ARG   A CD   1 
ATOM   5252 N NE   . ARG   B 1 134 ? -9.90658  -27.14393 15.43722  1.000 57.98475 ? 612 ARG   A NE   1 
ATOM   5253 C CZ   . ARG   B 1 134 ? -10.85693 -27.94149 14.97524  1.000 51.37835 ? 612 ARG   A CZ   1 
ATOM   5254 N NH1  . ARG   B 1 134 ? -11.08268 -28.06669 13.67759  1.000 59.04309 ? 612 ARG   A NH1  1 
ATOM   5255 N NH2  . ARG   B 1 134 ? -11.59619 -28.63012 15.83642  1.000 53.13729 ? 612 ARG   A NH2  1 
ATOM   5256 H H    . ARG   B 1 134 ? -5.30710  -28.22064 13.86243  1.000 38.90612 ? 612 ARG   A H    1 
ATOM   5257 H HA   . ARG   B 1 134 ? -6.07555  -26.45184 12.01642  1.000 36.30828 ? 612 ARG   A HA   1 
ATOM   5258 H HB2  . ARG   B 1 134 ? -6.20180  -26.20427 14.81825  1.000 35.32300 ? 612 ARG   A HB2  1 
ATOM   5259 H HB3  . ARG   B 1 134 ? -6.95367  -25.26094 13.78372  1.000 35.32300 ? 612 ARG   A HB3  1 
ATOM   5260 H HG2  . ARG   B 1 134 ? -8.09722  -27.36664 13.13272  1.000 45.87631 ? 612 ARG   A HG2  1 
ATOM   5261 H HG3  . ARG   B 1 134 ? -7.67885  -27.82374 14.59608  1.000 45.87631 ? 612 ARG   A HG3  1 
ATOM   5262 H HD2  . ARG   B 1 134 ? -8.72815  -25.56879 15.14909  1.000 58.79233 ? 612 ARG   A HD2  1 
ATOM   5263 H HD3  . ARG   B 1 134 ? -9.59528  -25.95485 13.87455  1.000 58.79233 ? 612 ARG   A HD3  1 
ATOM   5264 H HE   . ARG   B 1 134 ? -9.78182  -27.12103 16.28781  1.000 69.53571 ? 612 ARG   A HE   1 
ATOM   5265 H HH11 . ARG   B 1 134 ? -10.60707 -27.62455 13.11376  1.000 70.80572 ? 612 ARG   A HH11 1 
ATOM   5266 H HH12 . ARG   B 1 134 ? -11.70503 -28.59022 13.39795  1.000 70.80572 ? 612 ARG   A HH12 1 
ATOM   5267 H HH21 . ARG   B 1 134 ? -11.45451 -28.55459 16.68130  1.000 63.71876 ? 612 ARG   A HH21 1 
ATOM   5268 H HH22 . ARG   B 1 134 ? -12.21678 -29.15175 15.54942  1.000 63.71876 ? 612 ARG   A HH22 1 
ATOM   5269 N N    . LYS   B 1 135 ? -4.44546  -24.63121 12.01444  1.000 23.40003 ? 613 LYS   A N    1 
ATOM   5270 C CA   . LYS   B 1 135 ? -3.43083  -23.58411 11.92227  1.000 20.28705 ? 613 LYS   A CA   1 
ATOM   5271 C C    . LYS   B 1 135 ? -4.08127  -22.24601 12.24337  1.000 19.01781 ? 613 LYS   A C    1 
ATOM   5272 O O    . LYS   B 1 135 ? -5.28772  -22.04478 12.00122  1.000 18.11779 ? 613 LYS   A O    1 
ATOM   5273 C CB   . LYS   B 1 135 ? -2.80853  -23.56034 10.53003  1.000 20.56417 ? 613 LYS   A CB   1 
ATOM   5274 C CG   . LYS   B 1 135 ? -2.01311  -24.83368 10.19209  1.000 23.06013 ? 613 LYS   A CG   1 
ATOM   5275 C CD   . LYS   B 1 135 ? -1.71568  -24.94997 8.71359   1.000 23.30078 ? 613 LYS   A CD   1 
ATOM   5276 C CE   . LYS   B 1 135 ? -0.79273  -23.88248 8.18367   1.000 20.99784 ? 613 LYS   A CE   1 
ATOM   5277 N NZ   . LYS   B 1 135 ? 0.56757   -24.01282 8.70540   1.000 22.87389 ? 613 LYS   A NZ   1 
ATOM   5278 H H    . LYS   B 1 135 ? -5.05712  -24.54986 11.41539  1.000 28.03405 ? 613 LYS   A H    1 
ATOM   5279 H HA   . LYS   B 1 135 ? -2.71421  -23.73783 12.55766  1.000 24.29847 ? 613 LYS   A HA   1 
ATOM   5280 H HB2  . LYS   B 1 135 ? -3.51589  -23.46842 9.87270   1.000 24.63102 ? 613 LYS   A HB2  1 
ATOM   5281 H HB3  . LYS   B 1 135 ? -2.20129  -22.80618 10.47160  1.000 24.63102 ? 613 LYS   A HB3  1 
ATOM   5282 H HG2  . LYS   B 1 135 ? -1.16859  -24.81720 10.66898  1.000 27.62617 ? 613 LYS   A HG2  1 
ATOM   5283 H HG3  . LYS   B 1 135 ? -2.52901  -25.61096 10.45775  1.000 27.62617 ? 613 LYS   A HG3  1 
ATOM   5284 H HD2  . LYS   B 1 135 ? -1.29696  -25.80897 8.54718   1.000 27.91495 ? 613 LYS   A HD2  1 
ATOM   5285 H HD3  . LYS   B 1 135 ? -2.54986  -24.88685 8.22261   1.000 27.91495 ? 613 LYS   A HD3  1 
ATOM   5286 H HE2  . LYS   B 1 135 ? -0.75222  -23.94884 7.21679   1.000 25.15142 ? 613 LYS   A HE2  1 
ATOM   5287 H HE3  . LYS   B 1 135 ? -1.13251  -23.01158 8.44249   1.000 25.15142 ? 613 LYS   A HE3  1 
ATOM   5288 H HZ1  . LYS   B 1 135 ? 0.56120   -23.94374 9.59269   1.000 27.40268 ? 613 LYS   A HZ1  1 
ATOM   5289 H HZ2  . LYS   B 1 135 ? 0.90557   -24.80462 8.47976   1.000 27.40268 ? 613 LYS   A HZ2  1 
ATOM   5290 H HZ3  . LYS   B 1 135 ? 1.08519   -23.37148 8.36947   1.000 27.40268 ? 613 LYS   A HZ3  1 
ATOM   5291 N N    . HIS   B 1 136 ? -3.25778  -21.31677 12.76581  1.000 18.42712 ? 614 HIS   A N    1 
ATOM   5292 C CA   . HIS   B 1 136 ? -3.73665  -20.02876 13.24746  1.000 17.56065 ? 614 HIS   A CA   1 
ATOM   5293 C C    . HIS   B 1 136 ? -2.89126  -18.90519 12.66864  1.000 17.99755 ? 614 HIS   A C    1 
ATOM   5294 O O    . HIS   B 1 136 ? -1.66288  -18.93122 12.76801  1.000 17.91461 ? 614 HIS   A O    1 
ATOM   5295 C CB   . HIS   B 1 136 ? -3.71124  -19.96714 14.77422  1.000 18.89036 ? 614 HIS   A CB   1 
ATOM   5296 C CG   . HIS   B 1 136 ? -4.42875  -21.10826 15.43310  1.000 20.48632 ? 614 HIS   A CG   1 
ATOM   5297 N ND1  . HIS   B 1 136 ? -3.84318  -22.34133 15.63141  1.000 23.86712 ? 614 HIS   A ND1  1 
ATOM   5298 C CD2  . HIS   B 1 136 ? -5.68769  -21.20835 15.90040  1.000 22.34730 ? 614 HIS   A CD2  1 
ATOM   5299 C CE1  . HIS   B 1 136 ? -4.71434  -23.15015 16.20799  1.000 25.86850 ? 614 HIS   A CE1  1 
ATOM   5300 N NE2  . HIS   B 1 136 ? -5.84148  -22.48613 16.38002  1.000 24.08928 ? 614 HIS   A NE2  1 
ATOM   5301 H H    . HIS   B 1 136 ? -2.40812  -21.42119 12.84811  1.000 22.06656 ? 614 HIS   A H    1 
ATOM   5302 H HA   . HIS   B 1 136 ? -4.64854  -19.90097 12.94244  1.000 21.02679 ? 614 HIS   A HA   1 
ATOM   5303 H HB2  . HIS   B 1 136 ? -2.78839  -19.98501 15.07242  1.000 22.62245 ? 614 HIS   A HB2  1 
ATOM   5304 H HB3  . HIS   B 1 136 ? -4.13665  -19.14389 15.06092  1.000 22.62245 ? 614 HIS   A HB3  1 
ATOM   5305 H HD2  . HIS   B 1 136 ? -6.33223  -20.53792 15.89869  1.000 26.77078 ? 614 HIS   A HD2  1 
ATOM   5306 H HE1  . HIS   B 1 136 ? -4.55983  -24.03455 16.45062  1.000 30.99622 ? 614 HIS   A HE1  1 
ATOM   5307 H HE2  . HIS   B 1 136 ? -6.55771  -22.80271 16.73552  1.000 28.86115 ? 614 HIS   A HE2  1 
ATOM   5308 N N    . MET   B 1 137 ? -3.56578  -17.88841 12.12259  1.000 14.76402 ? 615 MET   A N    1 
ATOM   5309 C CA   . MET   B 1 137 ? -2.89499  -16.75682 11.50993  1.000 16.09540 ? 615 MET   A CA   1 
ATOM   5310 C C    . MET   B 1 137 ? -3.67548  -15.49664 11.84460  1.000 15.33159 ? 615 MET   A C    1 
ATOM   5311 O O    . MET   B 1 137 ? -4.90529  -15.45842 11.69215  1.000 14.56847 ? 615 MET   A O    1 
ATOM   5312 C CB   . MET   B 1 137 ? -2.80918  -16.92806 9.98278   1.000 17.30468 ? 615 MET   A CB   1 
ATOM   5313 C CG   . MET   B 1 137 ? -2.06318  -15.84447 9.30069   1.000 16.89860 ? 615 MET   A CG   1 
ATOM   5314 S SD   . MET   B 1 137 ? -2.15338  -15.96460 7.53121   1.000 17.63248 ? 615 MET   A SD   1 
ATOM   5315 C CE   . MET   B 1 137 ? -1.48150  -17.55684 7.22660   1.000 17.61738 ? 615 MET   A CE   1 
ATOM   5316 H H    . MET   B 1 137 ? -4.42394  -17.83771 12.09822  1.000 17.67084 ? 615 MET   A H    1 
ATOM   5317 H HA   . MET   B 1 137 ? -1.99279  -16.68399 11.85867  1.000 19.26850 ? 615 MET   A HA   1 
ATOM   5318 H HB2  . MET   B 1 137 ? -2.35953  -17.76514 9.78781   1.000 20.71963 ? 615 MET   A HB2  1 
ATOM   5319 H HB3  . MET   B 1 137 ? -3.70857  -16.94219 9.61973   1.000 20.71963 ? 615 MET   A HB3  1 
ATOM   5320 H HG2  . MET   B 1 137 ? -2.43657  -14.98866 9.56352   1.000 20.23233 ? 615 MET   A HG2  1 
ATOM   5321 H HG3  . MET   B 1 137 ? -1.12920  -15.89208 9.55821   1.000 20.23233 ? 615 MET   A HG3  1 
ATOM   5322 H HE1  . MET   B 1 137 ? -1.38450  -17.68085 6.26946   1.000 21.09486 ? 615 MET   A HE1  1 
ATOM   5323 H HE2  . MET   B 1 137 ? -0.61517  -17.62186 7.65804   1.000 21.09486 ? 615 MET   A HE2  1 
ATOM   5324 H HE3  . MET   B 1 137 ? -2.08209  -18.22744 7.58784   1.000 21.09486 ? 615 MET   A HE3  1 
ATOM   5325 N N    . TYR   B 1 138 ? -2.97285  -14.47577 12.31089  1.000 14.56249 ? 616 TYR   A N    1 
ATOM   5326 C CA   . TYR   B 1 138 ? -3.59530  -13.19584 12.55025  1.000 13.69246 ? 616 TYR   A CA   1 
ATOM   5327 C C    . TYR   B 1 138 ? -3.47768  -12.31316 11.32451  1.000 12.48022 ? 616 TYR   A C    1 
ATOM   5328 O O    . TYR   B 1 138 ? -2.48899  -12.36501 10.57813  1.000 14.18948 ? 616 TYR   A O    1 
ATOM   5329 C CB   . TYR   B 1 138 ? -2.91497  -12.47723 13.75494  1.000 14.80501 ? 616 TYR   A CB   1 
ATOM   5330 C CG   . TYR   B 1 138 ? -3.17722  -13.15127 15.07174  1.000 14.51619 ? 616 TYR   A CG   1 
ATOM   5331 C CD1  . TYR   B 1 138 ? -4.28691  -12.81485 15.83754  1.000 14.00974 ? 616 TYR   A CD1  1 
ATOM   5332 C CD2  . TYR   B 1 138 ? -2.34712  -14.12905 15.54298  1.000 14.33612 ? 616 TYR   A CD2  1 
ATOM   5333 C CE1  . TYR   B 1 138 ? -4.54372  -13.42282 17.02283  1.000 13.74668 ? 616 TYR   A CE1  1 
ATOM   5334 C CE2  . TYR   B 1 138 ? -2.58993  -14.76086 16.73508  1.000 15.03634 ? 616 TYR   A CE2  1 
ATOM   5335 C CZ   . TYR   B 1 138 ? -3.68834  -14.40188 17.48324  1.000 14.97135 ? 616 TYR   A CZ   1 
ATOM   5336 O OH   . TYR   B 1 138 ? -3.92772  -15.03392 18.67161  1.000 17.54256 ? 616 TYR   A OH   1 
ATOM   5337 H H    . TYR   B 1 138 ? -2.13330  -14.50456 12.49509  1.000 17.42900 ? 616 TYR   A H    1 
ATOM   5338 H HA   . TYR   B 1 138 ? -4.53451  -13.33066 12.75178  1.000 16.38496 ? 616 TYR   A HA   1 
ATOM   5339 H HB2  . TYR   B 1 138 ? -1.95565  -12.46476 13.61198  1.000 17.72002 ? 616 TYR   A HB2  1 
ATOM   5340 H HB3  . TYR   B 1 138 ? -3.25380  -11.57009 13.81141  1.000 17.72002 ? 616 TYR   A HB3  1 
ATOM   5341 H HD1  . TYR   B 1 138 ? -4.86772  -12.15684 15.53000  1.000 16.76570 ? 616 TYR   A HD1  1 
ATOM   5342 H HD2  . TYR   B 1 138 ? -1.60076  -14.37131 15.04382  1.000 17.15736 ? 616 TYR   A HD2  1 
ATOM   5343 H HE1  . TYR   B 1 138 ? -5.29088  -13.18125 17.52113  1.000 16.45003 ? 616 TYR   A HE1  1 
ATOM   5344 H HE2  . TYR   B 1 138 ? -2.01618  -15.42784 17.03650  1.000 17.99762 ? 616 TYR   A HE2  1 
ATOM   5345 H HH   . TYR   B 1 138 ? -4.62763  -14.72995 19.02281  1.000 21.00509 ? 616 TYR   A HH   1 
ATOM   5346 N N    . VAL   B 1 139 ? -4.47596  -11.44831 11.15193  1.000 13.21029 ? 617 VAL   A N    1 
ATOM   5347 C CA   . VAL   B 1 139 ? -4.41299  -10.28392 10.29124  1.000 12.89147 ? 617 VAL   A CA   1 
ATOM   5348 C C    . VAL   B 1 139 ? -4.20303  -9.09290  11.21466  1.000 14.24857 ? 617 VAL   A C    1 
ATOM   5349 O O    . VAL   B 1 139 ? -4.98961  -8.89940  12.14827  1.000 16.33046 ? 617 VAL   A O    1 
ATOM   5350 C CB   . VAL   B 1 139 ? -5.69752  -10.11928 9.46495   1.000 13.86366 ? 617 VAL   A CB   1 
ATOM   5351 C CG1  . VAL   B 1 139 ? -5.58068  -8.86509  8.58101   1.000 17.39597 ? 617 VAL   A CG1  1 
ATOM   5352 C CG2  . VAL   B 1 139 ? -5.94769  -11.38069 8.63973   1.000 17.26266 ? 617 VAL   A CG2  1 
ATOM   5353 H H    . VAL   B 1 139 ? -5.23651  -11.52453 11.54608  1.000 15.80636 ? 617 VAL   A H    1 
ATOM   5354 H HA   . VAL   B 1 139 ? -3.67608  -10.35936 9.66500   1.000 15.42378 ? 617 VAL   A HA   1 
ATOM   5355 H HB   . VAL   B 1 139 ? -6.46391  -9.99892  10.04725  1.000 16.59041 ? 617 VAL   A HB   1 
ATOM   5356 H HG11 . VAL   B 1 139 ? -6.31917  -8.85199  7.95222   1.000 20.82918 ? 617 VAL   A HG11 1 
ATOM   5357 H HG12 . VAL   B 1 139 ? -5.61278  -8.07684  9.14540   1.000 20.82918 ? 617 VAL   A HG12 1 
ATOM   5358 H HG13 . VAL   B 1 139 ? -4.73818  -8.89427  8.10119   1.000 20.82918 ? 617 VAL   A HG13 1 
ATOM   5359 H HG21 . VAL   B 1 139 ? -6.71338  -11.23382 8.06263   1.000 20.66921 ? 617 VAL   A HG21 1 
ATOM   5360 H HG22 . VAL   B 1 139 ? -5.16112  -11.56888 8.10420   1.000 20.66921 ? 617 VAL   A HG22 1 
ATOM   5361 H HG23 . VAL   B 1 139 ? -6.12368  -12.12148 9.24069   1.000 20.66921 ? 617 VAL   A HG23 1 
ATOM   5362 N N    . VAL   B 1 140 ? -3.14888  -8.30420  10.95092  1.000 14.13741 ? 618 VAL   A N    1 
ATOM   5363 C CA   . VAL   B 1 140 ? -2.57210  -7.38268  11.92065  1.000 14.47488 ? 618 VAL   A CA   1 
ATOM   5364 C C    . VAL   B 1 140 ? -2.44551  -5.99646  11.31354  1.000 14.80987 ? 618 VAL   A C    1 
ATOM   5365 O O    . VAL   B 1 140 ? -1.89811  -5.83321  10.21972  1.000 14.36358 ? 618 VAL   A O    1 
ATOM   5366 C CB   . VAL   B 1 140 ? -1.19074  -7.88375  12.38787  1.000 13.97890 ? 618 VAL   A CB   1 
ATOM   5367 C CG1  . VAL   B 1 140 ? -0.66084  -7.01450  13.56643  1.000 12.39321 ? 618 VAL   A CG1  1 
ATOM   5368 C CG2  . VAL   B 1 140 ? -1.26122  -9.34730  12.79532  1.000 15.52075 ? 618 VAL   A CG2  1 
ATOM   5369 H H    . VAL   B 1 140 ? -2.74460  -8.29104  10.19198  1.000 16.91891 ? 618 VAL   A H    1 
ATOM   5370 H HA   . VAL   B 1 140 ? -3.17391  -7.30770  12.67769  1.000 17.32386 ? 618 VAL   A HA   1 
ATOM   5371 H HB   . VAL   B 1 140 ? -0.56674  -7.80475  11.64943  1.000 16.72870 ? 618 VAL   A HB   1 
ATOM   5372 H HG11 . VAL   B 1 140 ? 0.15167   -7.41474  13.91362  1.000 14.82586 ? 618 VAL   A HG11 1 
ATOM   5373 H HG12 . VAL   B 1 140 ? -0.47578  -6.11979  13.24062  1.000 14.82586 ? 618 VAL   A HG12 1 
ATOM   5374 H HG13 . VAL   B 1 140 ? -1.33604  -6.98017  14.26200  1.000 14.82586 ? 618 VAL   A HG13 1 
ATOM   5375 H HG21 . VAL   B 1 140 ? -0.42092  -9.60100  13.20815  1.000 18.57892 ? 618 VAL   A HG21 1 
ATOM   5376 H HG22 . VAL   B 1 140 ? -1.98852  -9.46477  13.42630  1.000 18.57892 ? 618 VAL   A HG22 1 
ATOM   5377 H HG23 . VAL   B 1 140 ? -1.41814  -9.88784  12.00532  1.000 18.57892 ? 618 VAL   A HG23 1 
ATOM   5378 N N    . ARG   B 1 141 ? -2.86970  -4.99172  12.05819  1.000 13.73438 ? 619 ARG   A N    1 
ATOM   5379 C CA   . ARG   B 1 141 ? -2.54360  -3.61202  11.73083  1.000 15.13698 ? 619 ARG   A CA   1 
ATOM   5380 C C    . ARG   B 1 141 ? -1.15619  -3.31417  12.27442  1.000 13.72732 ? 619 ARG   A C    1 
ATOM   5381 O O    . ARG   B 1 141 ? -0.93106  -3.41360  13.48416  1.000 14.60611 ? 619 ARG   A O    1 
ATOM   5382 C CB   . ARG   B 1 141 ? -3.54898  -2.63233  12.32755  1.000 18.69811 ? 619 ARG   A CB   1 
ATOM   5383 C CG   . ARG   B 1 141 ? -4.96951  -2.74317  11.81822  1.000 25.34133 ? 619 ARG   A CG   1 
ATOM   5384 C CD   . ARG   B 1 141 ? -5.74155  -1.49230  12.29651  1.000 25.65440 ? 619 ARG   A CD   1 
ATOM   5385 N NE   . ARG   B 1 141 ? -7.17255  -1.57615  12.07096  1.000 41.34215 ? 619 ARG   A NE   1 
ATOM   5386 C CZ   . ARG   B 1 141 ? -7.78859  -0.96813  11.06883  1.000 45.47410 ? 619 ARG   A CZ   1 
ATOM   5387 N NH1  . ARG   B 1 141 ? -7.10574  -0.29926  10.14350  1.000 45.16855 ? 619 ARG   A NH1  1 
ATOM   5388 N NH2  . ARG   B 1 141 ? -9.11605  -1.02937  10.99483  1.000 47.64488 ? 619 ARG   A NH2  1 
ATOM   5389 H H    . ARG   B 1 141 ? -3.35201  -5.08072  12.76463  1.000 16.43527 ? 619 ARG   A H    1 
ATOM   5390 H HA   . ARG   B 1 141 ? -2.56646  -3.50213  10.76734  1.000 18.11839 ? 619 ARG   A HA   1 
ATOM   5391 H HB2  . ARG   B 1 141 ? -3.57712  -2.77422  13.28671  1.000 22.39175 ? 619 ARG   A HB2  1 
ATOM   5392 H HB3  . ARG   B 1 141 ? -3.24523  -1.73164  12.13419  1.000 22.39175 ? 619 ARG   A HB3  1 
ATOM   5393 H HG2  . ARG   B 1 141 ? -4.97677  -2.77278  10.84870  1.000 30.36361 ? 619 ARG   A HG2  1 
ATOM   5394 H HG3  . ARG   B 1 141 ? -5.39353  -3.53813  12.17759  1.000 30.36361 ? 619 ARG   A HG3  1 
ATOM   5395 H HD2  . ARG   B 1 141 ? -5.59724  -1.37983  13.24910  1.000 30.73930 ? 619 ARG   A HD2  1 
ATOM   5396 H HD3  . ARG   B 1 141 ? -5.41036  -0.71689  11.81697  1.000 30.73930 ? 619 ARG   A HD3  1 
ATOM   5397 H HE   . ARG   B 1 141 ? -7.64472  -2.04471  12.61604  1.000 49.56460 ? 619 ARG   A HE   1 
ATOM   5398 H HH11 . ARG   B 1 141 ? -6.24806  -0.25596  10.18950  1.000 54.15628 ? 619 ARG   A HH11 1 
ATOM   5399 H HH12 . ARG   B 1 141 ? -7.52200  0.08983   9.49934   1.000 54.15628 ? 619 ARG   A HH12 1 
ATOM   5400 H HH21 . ARG   B 1 141 ? -9.56066  -1.45920  11.59246  1.000 57.12787 ? 619 ARG   A HH21 1 
ATOM   5401 H HH22 . ARG   B 1 141 ? -9.52919  -0.63911  10.34938  1.000 57.12787 ? 619 ARG   A HH22 1 
ATOM   5402 N N    . VAL   B 1 142 ? -0.22594  -2.93815  11.40326  1.000 13.58058 ? 620 VAL   A N    1 
ATOM   5403 C CA   . VAL   B 1 142 ? 1.16911   -2.73727  11.79339  1.000 14.28278 ? 620 VAL   A CA   1 
ATOM   5404 C C    . VAL   B 1 142 ? 1.61517   -1.33683  11.39885  1.000 14.68808 ? 620 VAL   A C    1 
ATOM   5405 O O    . VAL   B 1 142 ? 1.43349   -0.91207  10.25763  1.000 13.63551 ? 620 VAL   A O    1 
ATOM   5406 C CB   . VAL   B 1 142 ? 2.09926   -3.80289  11.16954  1.000 12.98751 ? 620 VAL   A CB   1 
ATOM   5407 C CG1  . VAL   B 1 142 ? 3.54879   -3.57016  11.62324  1.000 14.76667 ? 620 VAL   A CG1  1 
ATOM   5408 C CG2  . VAL   B 1 142 ? 1.64143   -5.19831  11.49676  1.000 14.52959 ? 620 VAL   A CG2  1 
ATOM   5409 H H    . VAL   B 1 142 ? -0.37921  -2.79109  10.56990  1.000 16.25071 ? 620 VAL   A H    1 
ATOM   5410 H HA   . VAL   B 1 142 ? 1.22565   -2.80049  12.75968  1.000 17.09335 ? 620 VAL   A HA   1 
ATOM   5411 H HB   . VAL   B 1 142 ? 2.06431   -3.71678  10.20400  1.000 15.53903 ? 620 VAL   A HB   1 
ATOM   5412 H HG11 . VAL   B 1 142 ? 4.08531   -4.33850  11.37281  1.000 17.67401 ? 620 VAL   A HG11 1 
ATOM   5413 H HG12 . VAL   B 1 142 ? 3.89101   -2.77247  11.19026  1.000 17.67401 ? 620 VAL   A HG12 1 
ATOM   5414 H HG13 . VAL   B 1 142 ? 3.56378   -3.45603  12.58639  1.000 17.67401 ? 620 VAL   A HG13 1 
ATOM   5415 H HG21 . VAL   B 1 142 ? 2.28762   -5.83247  11.14864  1.000 17.38952 ? 620 VAL   A HG21 1 
ATOM   5416 H HG22 . VAL   B 1 142 ? 1.57323   -5.29059  12.45995  1.000 17.38952 ? 620 VAL   A HG22 1 
ATOM   5417 H HG23 . VAL   B 1 142 ? 0.77516   -5.35053  11.08772  1.000 17.38952 ? 620 VAL   A HG23 1 
ATOM   5418 N N    . LEU   B 1 143 ? 2.21336   -0.62703  12.34544  1.000 13.98744 ? 621 LEU   A N    1 
ATOM   5419 C CA   . LEU   B 1 143 ? 2.75425   0.70588   12.09601  1.000 14.39921 ? 621 LEU   A CA   1 
ATOM   5420 C C    . LEU   B 1 143 ? 4.16464   0.53502   11.56866  1.000 14.77487 ? 621 LEU   A C    1 
ATOM   5421 O O    . LEU   B 1 143 ? 5.15173   0.70021   12.28452  1.000 16.20657 ? 621 LEU   A O    1 
ATOM   5422 C CB   . LEU   B 1 143 ? 2.69087   1.55983   13.35681  1.000 15.32503 ? 621 LEU   A CB   1 
ATOM   5423 C CG   . LEU   B 1 143 ? 1.25063   1.86622   13.80525  1.000 14.64955 ? 621 LEU   A CG   1 
ATOM   5424 C CD1  . LEU   B 1 143 ? 1.18872   2.36944   15.22748  1.000 15.32903 ? 621 LEU   A CD1  1 
ATOM   5425 C CD2  . LEU   B 1 143 ? 0.60132   2.88599   12.86845  1.000 16.38556 ? 621 LEU   A CD2  1 
ATOM   5426 H H    . LEU   B 1 143 ? 2.32128   -0.89805  13.15445  1.000 16.73894 ? 621 LEU   A H    1 
ATOM   5427 H HA   . LEU   B 1 143 ? 2.22714   1.15752   11.41846  1.000 17.23307 ? 621 LEU   A HA   1 
ATOM   5428 H HB2  . LEU   B 1 143 ? 3.13553   1.08793   14.07827  1.000 18.34405 ? 621 LEU   A HB2  1 
ATOM   5429 H HB3  . LEU   B 1 143 ? 3.13800   2.40375   13.18718  1.000 18.34405 ? 621 LEU   A HB3  1 
ATOM   5430 H HG   . LEU   B 1 143 ? 0.75171   1.03516   13.76872  1.000 17.53348 ? 621 LEU   A HG   1 
ATOM   5431 H HD11 . LEU   B 1 143 ? 0.26298   2.53868   15.46257  1.000 18.34885 ? 621 LEU   A HD11 1 
ATOM   5432 H HD12 . LEU   B 1 143 ? 1.56197   1.69589   15.81732  1.000 18.34885 ? 621 LEU   A HD12 1 
ATOM   5433 H HD13 . LEU   B 1 143 ? 1.70236   3.18952   15.29495  1.000 18.34885 ? 621 LEU   A HD13 1 
ATOM   5434 H HD21 . LEU   B 1 143 ? -0.27208  3.12375   13.21707  1.000 19.61668 ? 621 LEU   A HD21 1 
ATOM   5435 H HD22 . LEU   B 1 143 ? 1.16435   3.67443   12.82092  1.000 19.61668 ? 621 LEU   A HD22 1 
ATOM   5436 H HD23 . LEU   B 1 143 ? 0.50949   2.49148   11.98707  1.000 19.61668 ? 621 LEU   A HD23 1 
ATOM   5437 N N    . THR   B 1 144 ? 4.24261   0.22709   10.26761  1.000 13.94267 ? 622 THR   A N    1 
ATOM   5438 C CA   . THR   B 1 144 ? 5.54429   0.06023   9.63120   1.000 16.00839 ? 622 THR   A CA   1 
ATOM   5439 C C    . THR   B 1 144 ? 6.25162   1.40104   9.42917   1.000 15.44808 ? 622 THR   A C    1 
ATOM   5440 O O    . THR   B 1 144 ? 7.48560   1.44813   9.41748   1.000 15.63292 ? 622 THR   A O    1 
ATOM   5441 C CB   . THR   B 1 144 ? 5.37614   -0.66296  8.29877   1.000 15.86374 ? 622 THR   A CB   1 
ATOM   5442 O OG1  . THR   B 1 144 ? 4.26551   -0.08057  7.59090   1.000 17.31457 ? 622 THR   A OG1  1 
ATOM   5443 C CG2  . THR   B 1 144 ? 5.09728   -2.14925  8.51941   1.000 16.08481 ? 622 THR   A CG2  1 
ATOM   5444 H H    . THR   B 1 144 ? 3.56867   0.11265   9.74577   1.000 16.68522 ? 622 THR   A H    1 
ATOM   5445 H HA   . THR   B 1 144 ? 6.10752   -0.48561  10.20192  1.000 19.16408 ? 622 THR   A HA   1 
ATOM   5446 H HB   . THR   B 1 144 ? 6.18998   -0.58006  7.77753   1.000 18.99050 ? 622 THR   A HB   1 
ATOM   5447 H HG1  . THR   B 1 144 ? 4.40467   0.73762   7.46125   1.000 20.73150 ? 622 THR   A HG1  1 
ATOM   5448 H HG21 . THR   B 1 144 ? 5.11113   -2.61895  7.67083   1.000 19.25579 ? 622 THR   A HG21 1 
ATOM   5449 H HG22 . THR   B 1 144 ? 5.77300   -2.53075  9.10144   1.000 19.25579 ? 622 THR   A HG22 1 
ATOM   5450 H HG23 . THR   B 1 144 ? 4.22610   -2.26602  8.92966   1.000 19.25579 ? 622 THR   A HG23 1 
ATOM   5451 N N    . GLY   B 1 145 ? 5.49879   2.47797   9.25603   1.000 13.93772 ? 623 GLY   A N    1 
ATOM   5452 C CA   . GLY   B 1 145 ? 6.07082   3.79188   9.09814   1.000 15.58429 ? 623 GLY   A CA   1 
ATOM   5453 C C    . GLY   B 1 145 ? 7.14105   3.86452   8.04284   1.000 17.74657 ? 623 GLY   A C    1 
ATOM   5454 O O    . GLY   B 1 145 ? 6.97371   3.38814   6.93018   1.000 17.48999 ? 623 GLY   A O    1 
ATOM   5455 H H    . GLY   B 1 145 ? 4.63934   2.46985   9.22638   1.000 16.67928 ? 623 GLY   A H    1 
ATOM   5456 H HA2  . GLY   B 1 145 ? 5.36829   4.41522   8.85566   1.000 18.65516 ? 623 GLY   A HA2  1 
ATOM   5457 H HA3  . GLY   B 1 145 ? 6.46215   4.06944   9.94118   1.000 18.65516 ? 623 GLY   A HA3  1 
ATOM   5458 N N    . VAL   B 1 146 ? 8.23522   4.53289   8.38195   1.000 16.93244 ? 624 VAL   A N    1 
ATOM   5459 C CA   . VAL   B 1 146 ? 9.40184   4.65088   7.51845   1.000 18.25978 ? 624 VAL   A CA   1 
ATOM   5460 C C    . VAL   B 1 146 ? 10.32980  3.49914   7.88005   1.000 17.53951 ? 624 VAL   A C    1 
ATOM   5461 O O    . VAL   B 1 146 ? 10.66731  3.29762   9.06279   1.000 17.64337 ? 624 VAL   A O    1 
ATOM   5462 C CB   . VAL   B 1 146 ? 10.09699  6.00757   7.69822   1.000 19.56014 ? 624 VAL   A CB   1 
ATOM   5463 C CG1  . VAL   B 1 146 ? 11.25881  6.13504   6.73816   1.000 21.90151 ? 624 VAL   A CG1  1 
ATOM   5464 C CG2  . VAL   B 1 146 ? 9.11923   7.12866   7.49051   1.000 21.67804 ? 624 VAL   A CG2  1 
ATOM   5465 H H    . VAL   B 1 146 ? 8.32956   4.94093   9.13308   1.000 20.27294 ? 624 VAL   A H    1 
ATOM   5466 H HA   . VAL   B 1 146 ? 9.14308   4.58383   6.58601   1.000 21.86575 ? 624 VAL   A HA   1 
ATOM   5467 H HB   . VAL   B 1 146 ? 10.44113  6.06771   8.60313   1.000 23.42618 ? 624 VAL   A HB   1 
ATOM   5468 H HG11 . VAL   B 1 146 ? 11.63673  7.02498   6.81613   1.000 26.23583 ? 624 VAL   A HG11 1 
ATOM   5469 H HG12 . VAL   B 1 146 ? 11.92859  5.47038   6.96291   1.000 26.23583 ? 624 VAL   A HG12 1 
ATOM   5470 H HG13 . VAL   B 1 146 ? 10.93881  5.98961   5.83408   1.000 26.23583 ? 624 VAL   A HG13 1 
ATOM   5471 H HG21 . VAL   B 1 146 ? 9.59778   7.97223   7.50725   1.000 25.96766 ? 624 VAL   A HG21 1 
ATOM   5472 H HG22 . VAL   B 1 146 ? 8.68343   7.01257   6.63173   1.000 25.96766 ? 624 VAL   A HG22 1 
ATOM   5473 H HG23 . VAL   B 1 146 ? 8.45974   7.10832   8.20154   1.000 25.96766 ? 624 VAL   A HG23 1 
ATOM   5474 N N    . PHE   B 1 147 ? 10.72469  2.72445   6.87764   1.000 18.58333 ? 625 PHE   A N    1 
ATOM   5475 C CA   . PHE   B 1 147 ? 11.48451  1.50208   7.13038   1.000 17.07734 ? 625 PHE   A CA   1 
ATOM   5476 C C    . PHE   B 1 147 ? 12.78077  1.47326   6.33455   1.000 18.45207 ? 625 PHE   A C    1 
ATOM   5477 O O    . PHE   B 1 147 ? 12.96335  2.20385   5.36409   1.000 16.76026 ? 625 PHE   A O    1 
ATOM   5478 C CB   . PHE   B 1 147 ? 10.64338  0.23071   6.81794   1.000 15.70800 ? 625 PHE   A CB   1 
ATOM   5479 C CG   . PHE   B 1 147 ? 9.95816   0.27256   5.49591   1.000 17.84457 ? 625 PHE   A CG   1 
ATOM   5480 C CD1  . PHE   B 1 147 ? 10.58375  -0.20152  4.36491   1.000 18.52116 ? 625 PHE   A CD1  1 
ATOM   5481 C CD2  . PHE   B 1 147 ? 8.65813   0.80161   5.38075   1.000 20.79557 ? 625 PHE   A CD2  1 
ATOM   5482 C CE1  . PHE   B 1 147 ? 9.95139   -0.17149  3.12739   1.000 22.90632 ? 625 PHE   A CE1  1 
ATOM   5483 C CE2  . PHE   B 1 147 ? 8.02095   0.85489   4.15312   1.000 22.46121 ? 625 PHE   A CE2  1 
ATOM   5484 C CZ   . PHE   B 1 147 ? 8.66930   0.37271   3.02534   1.000 26.08640 ? 625 PHE   A CZ   1 
ATOM   5485 H H    . PHE   B 1 147 ? 10.56676  2.88288   6.04725   1.000 22.25401 ? 625 PHE   A H    1 
ATOM   5486 H HA   . PHE   B 1 147 ? 11.73226  1.49399   8.06817   1.000 20.44682 ? 625 PHE   A HA   1 
ATOM   5487 H HB2  . PHE   B 1 147 ? 11.23138  -0.54074  6.82203   1.000 18.80361 ? 625 PHE   A HB2  1 
ATOM   5488 H HB3  . PHE   B 1 147 ? 9.96202   0.13214   7.50126   1.000 18.80361 ? 625 PHE   A HB3  1 
ATOM   5489 H HD1  . PHE   B 1 147 ? 11.44438  -0.54789  4.42997   1.000 22.17941 ? 625 PHE   A HD1  1 
ATOM   5490 H HD2  . PHE   B 1 147 ? 8.22249   1.11900   6.13862   1.000 24.90870 ? 625 PHE   A HD2  1 
ATOM   5491 H HE1  . PHE   B 1 147 ? 10.37832  -0.51080  2.37406   1.000 27.44160 ? 625 PHE   A HE1  1 
ATOM   5492 H HE2  . PHE   B 1 147 ? 7.16465   1.21124   4.08480   1.000 26.90747 ? 625 PHE   A HE2  1 
ATOM   5493 H HZ   . PHE   B 1 147 ? 8.24799   0.41208   2.19718   1.000 31.25769 ? 625 PHE   A HZ   1 
ATOM   5494 N N    . THR   B 1 148 ? 13.68680  0.60973   6.78877   1.000 16.75283 ? 626 THR   A N    1 
ATOM   5495 C CA   . THR   B 1 148 ? 14.96709  0.37422   6.12929   1.000 16.42408 ? 626 THR   A CA   1 
ATOM   5496 C C    . THR   B 1 148 ? 15.24833  -1.12103  6.18624   1.000 16.54393 ? 626 THR   A C    1 
ATOM   5497 O O    . THR   B 1 148 ? 14.52116  -1.89192  6.82384   1.000 16.71582 ? 626 THR   A O    1 
ATOM   5498 C CB   . THR   B 1 148 ? 16.08018  1.19305   6.78507   1.000 19.22749 ? 626 THR   A CB   1 
ATOM   5499 O OG1  . THR   B 1 148 ? 17.28799  1.08037   6.00930   1.000 21.75701 ? 626 THR   A OG1  1 
ATOM   5500 C CG2  . THR   B 1 148 ? 16.36635  0.67417   8.22005   1.000 20.74273 ? 626 THR   A CG2  1 
ATOM   5501 H H    . THR   B 1 148 ? 13.57910  0.13503   7.49776   1.000 20.05741 ? 626 THR   A H    1 
ATOM   5502 H HA   . THR   B 1 148 ? 14.93055  0.63688   5.19625   1.000 19.66291 ? 626 THR   A HA   1 
ATOM   5503 H HB   . THR   B 1 148 ? 15.80372  2.12151   6.83441   1.000 23.02700 ? 626 THR   A HB   1 
ATOM   5504 H HG1  . THR   B 1 148 ? 17.15711  1.36705   5.23066   1.000 26.06243 ? 626 THR   A HG1  1 
ATOM   5505 H HG21 . THR   B 1 148 ? 16.95041  1.29265   8.68615   1.000 24.84529 ? 626 THR   A HG21 1 
ATOM   5506 H HG22 . THR   B 1 148 ? 15.53606  0.59171   8.71475   1.000 24.84529 ? 626 THR   A HG22 1 
ATOM   5507 H HG23 . THR   B 1 148 ? 16.79604  -0.19451  8.17919   1.000 24.84529 ? 626 THR   A HG23 1 
ATOM   5508 N N    . LYS   B 1 149 ? 16.32795  -1.54052  5.52711   1.000 18.70477 ? 627 LYS   A N    1 
ATOM   5509 C CA   . LYS   B 1 149 ? 16.69515  -2.94676  5.56562   1.000 17.41496 ? 627 LYS   A CA   1 
ATOM   5510 C C    . LYS   B 1 149 ? 17.22741  -3.35747  6.93189   1.000 16.97114 ? 627 LYS   A C    1 
ATOM   5511 O O    . LYS   B 1 149 ? 18.03676  -2.67050  7.54049   1.000 17.88507 ? 627 LYS   A O    1 
ATOM   5512 C CB   . LYS   B 1 149 ? 17.74547  -3.23957  4.48928   1.000 21.90669 ? 627 LYS   A CB   1 
ATOM   5513 C CG   . LYS   B 1 149 ? 18.12262  -4.69214  4.39955   1.000 22.49488 ? 627 LYS   A CG   1 
ATOM   5514 C CD   . LYS   B 1 149 ? 19.12481  -4.92124  3.24317   1.000 28.98246 ? 627 LYS   A CD   1 
ATOM   5515 C CE   . LYS   B 1 149 ? 19.58665  -6.36574  3.19505   1.000 30.42553 ? 627 LYS   A CE   1 
ATOM   5516 N NZ   . LYS   B 1 149 ? 20.23588  -6.67659  1.88286   1.000 39.52877 ? 627 LYS   A NZ   1 
ATOM   5517 H H    . LYS   B 1 149 ? 16.85005  -1.03975  5.06209   1.000 22.39973 ? 627 LYS   A H    1 
ATOM   5518 H HA   . LYS   B 1 149 ? 15.90350  -3.47959  5.39160   1.000 20.85196 ? 627 LYS   A HA   1 
ATOM   5519 H HB2  . LYS   B 1 149 ? 17.39298  -2.97011  3.62670   1.000 26.24205 ? 627 LYS   A HB2  1 
ATOM   5520 H HB3  . LYS   B 1 149 ? 18.54931  -2.73564  4.69129   1.000 26.24205 ? 627 LYS   A HB3  1 
ATOM   5521 H HG2  . LYS   B 1 149 ? 18.53935  -4.97171  5.22965   1.000 26.94787 ? 627 LYS   A HG2  1 
ATOM   5522 H HG3  . LYS   B 1 149 ? 17.32928  -5.22420  4.23095   1.000 26.94787 ? 627 LYS   A HG3  1 
ATOM   5523 H HD2  . LYS   B 1 149 ? 18.69714  -4.70837  2.39896   1.000 34.73297 ? 627 LYS   A HD2  1 
ATOM   5524 H HD3  . LYS   B 1 149 ? 19.90200  -4.35560  3.37328   1.000 34.73297 ? 627 LYS   A HD3  1 
ATOM   5525 H HE2  . LYS   B 1 149 ? 20.23203  -6.52245  3.90204   1.000 36.46465 ? 627 LYS   A HE2  1 
ATOM   5526 H HE3  . LYS   B 1 149 ? 18.82289  -6.95316  3.30688   1.000 36.46465 ? 627 LYS   A HE3  1 
ATOM   5527 H HZ1  . LYS   B 1 149 ? 19.65902  -6.54256  1.21850   1.000 47.38853 ? 627 LYS   A HZ1  1 
ATOM   5528 H HZ2  . LYS   B 1 149 ? 20.94365  -6.15086  1.76130   1.000 47.38853 ? 627 LYS   A HZ2  1 
ATOM   5529 H HZ3  . LYS   B 1 149 ? 20.50111  -7.52603  1.86812   1.000 47.38853 ? 627 LYS   A HZ3  1 
ATOM   5530 N N    . GLY   B 1 150 ? 16.75764  -4.50776  7.41679   1.000 15.19395 ? 628 GLY   A N    1 
ATOM   5531 C CA   . GLY   B 1 150 ? 17.18769  -5.02697  8.69493   1.000 16.82715 ? 628 GLY   A CA   1 
ATOM   5532 C C    . GLY   B 1 150 ? 18.45073  -5.86974  8.57637   1.000 16.82594 ? 628 GLY   A C    1 
ATOM   5533 O O    . GLY   B 1 150 ? 18.98299  -6.07441  7.49481   1.000 16.46917 ? 628 GLY   A O    1 
ATOM   5534 H H    . GLY   B 1 150 ? 16.18321  -5.00457  7.01329   1.000 18.18675 ? 628 GLY   A H    1 
ATOM   5535 H HA2  . GLY   B 1 150 ? 17.36680  -4.28904  9.29849   1.000 20.14660 ? 628 GLY   A HA2  1 
ATOM   5536 H HA3  . GLY   B 1 150 ? 16.48460  -5.57921  9.07123   1.000 20.14660 ? 628 GLY   A HA3  1 
ATOM   5537 N N    . ARG   B 1 151 ? 18.88339  -6.38457  9.72162   1.000 17.85981 ? 629 ARG   A N    1 
ATOM   5538 C CA   A ARG   B 1 151 ? 20.06237  -7.24029  9.80366   0.642 19.41683 ? 629 ARG   A CA   1 
ATOM   5539 C CA   B ARG   B 1 151 ? 20.07541  -7.21984  9.81205   0.358 19.42419 ? 629 ARG   A CA   1 
ATOM   5540 C C    . ARG   B 1 151 ? 20.05392  -7.94230  11.15141  1.000 17.76347 ? 629 ARG   A C    1 
ATOM   5541 O O    . ARG   B 1 151 ? 19.37201  -7.51899  12.09458  1.000 15.44282 ? 629 ARG   A O    1 
ATOM   5542 C CB   A ARG   B 1 151 ? 21.36062  -6.44538  9.61033   0.642 20.82917 ? 629 ARG   A CB   1 
ATOM   5543 C CB   B ARG   B 1 151 ? 21.36129  -6.39716  9.66367   0.358 20.79526 ? 629 ARG   A CB   1 
ATOM   5544 C CG   A ARG   B 1 151 ? 21.61491  -5.37891  10.65943  0.642 21.20532 ? 629 ARG   A CG   1 
ATOM   5545 C CG   B ARG   B 1 151 ? 21.82927  -5.72103  10.94513  0.358 21.17056 ? 629 ARG   A CG   1 
ATOM   5546 C CD   A ARG   B 1 151 ? 22.98730  -4.69597  10.42632  0.642 21.73836 ? 629 ARG   A CD   1 
ATOM   5547 C CD   B ARG   B 1 151 ? 22.95985  -4.71056  10.66751  0.358 21.68388 ? 629 ARG   A CD   1 
ATOM   5548 N NE   A ARG   B 1 151 ? 23.31327  -3.73115  11.46977  0.642 21.00150 ? 629 ARG   A NE   1 
ATOM   5549 N NE   B ARG   B 1 151 ? 22.42449  -3.40886  10.28366  0.358 23.95817 ? 629 ARG   A NE   1 
ATOM   5550 C CZ   A ARG   B 1 151 ? 24.14855  -3.96380  12.47672  0.642 24.12031 ? 629 ARG   A CZ   1 
ATOM   5551 C CZ   B ARG   B 1 151 ? 22.46586  -2.32476  11.04247  0.358 21.80863 ? 629 ARG   A CZ   1 
ATOM   5552 N NH1  A ARG   B 1 151 ? 24.77839  -5.12335  12.60766  0.642 27.11404 ? 629 ARG   A NH1  1 
ATOM   5553 N NH1  B ARG   B 1 151 ? 23.08506  -2.31984  12.21475  0.358 24.40033 ? 629 ARG   A NH1  1 
ATOM   5554 N NH2  A ARG   B 1 151 ? 24.37836  -3.00002  13.36581  0.642 27.06442 ? 629 ARG   A NH2  1 
ATOM   5555 N NH2  B ARG   B 1 151 ? 21.87487  -1.21767  10.61662  0.358 17.13817 ? 629 ARG   A NH2  1 
ATOM   5556 H H    A ARG   B 1 151 ? 18.50418  -6.25098  10.48186  0.642 21.38578 ? 629 ARG   A H    1 
ATOM   5557 H H    B ARG   B 1 151 ? 18.49512  -6.26225  10.47917  0.358 21.38578 ? 629 ARG   A H    1 
ATOM   5558 H HA   A ARG   B 1 151 ? 20.02006  -7.91305  9.10616   0.642 23.25422 ? 629 ARG   A HA   1 
ATOM   5559 H HA   B ARG   B 1 151 ? 20.05920  -7.88037  9.10189   0.358 23.26304 ? 629 ARG   A HA   1 
ATOM   5560 H HB2  A ARG   B 1 151 ? 22.10724  -7.06408  9.63614   0.642 24.94901 ? 629 ARG   A HB2  1 
ATOM   5561 H HB2  B ARG   B 1 151 ? 22.07239  -6.98621  9.36660   0.358 24.90833 ? 629 ARG   A HB2  1 
ATOM   5562 H HB3  A ARG   B 1 151 ? 21.32555  -6.00355  8.74751   0.642 24.94901 ? 629 ARG   A HB3  1 
ATOM   5563 H HB3  B ARG   B 1 151 ? 21.20906  -5.70213  9.00438   0.358 24.90833 ? 629 ARG   A HB3  1 
ATOM   5564 H HG2  A ARG   B 1 151 ? 20.92158  -4.70242  10.60878  0.642 25.40040 ? 629 ARG   A HG2  1 
ATOM   5565 H HG2  B ARG   B 1 151 ? 21.08615  -5.24476  11.34742  0.358 25.35868 ? 629 ARG   A HG2  1 
ATOM   5566 H HG3  A ARG   B 1 151 ? 21.61851  -5.78497  11.54034  0.642 25.40040 ? 629 ARG   A HG3  1 
ATOM   5567 H HG3  B ARG   B 1 151 ? 22.16431  -6.39282  11.55942  0.358 25.35868 ? 629 ARG   A HG3  1 
ATOM   5568 H HD2  A ARG   B 1 151 ? 23.68131  -5.37355  10.41532  0.642 26.04005 ? 629 ARG   A HD2  1 
ATOM   5569 H HD2  B ARG   B 1 151 ? 23.49431  -4.59729  11.46902  0.358 25.97467 ? 629 ARG   A HD2  1 
ATOM   5570 H HD3  A ARG   B 1 151 ? 22.96832  -4.22669  9.57761   0.642 26.04005 ? 629 ARG   A HD3  1 
ATOM   5571 H HD3  B ARG   B 1 151 ? 23.51440  -5.03912  9.94265   0.358 25.97467 ? 629 ARG   A HD3  1 
ATOM   5572 H HE   A ARG   B 1 151 ? 22.93899  -2.95785  11.43083  0.642 25.15582 ? 629 ARG   A HE   1 
ATOM   5573 H HE   B ARG   B 1 151 ? 22.05591  -3.34093  9.50962   0.358 28.70382 ? 629 ARG   A HE   1 
ATOM   5574 H HH11 A ARG   B 1 151 ? 24.65104  -5.74929  12.03183  0.642 32.49086 ? 629 ARG   A HH11 1 
ATOM   5575 H HH11 B ARG   B 1 151 ? 23.47281  -3.03281  12.49923  0.358 29.23441 ? 629 ARG   A HH11 1 
ATOM   5576 H HH12 A ARG   B 1 151 ? 25.31422  -5.24943  13.26841  0.642 32.49086 ? 629 ARG   A HH12 1 
ATOM   5577 H HH12 B ARG   B 1 151 ? 23.09898  -1.60369  12.69070  0.358 29.23441 ? 629 ARG   A HH12 1 
ATOM   5578 H HH21 A ARG   B 1 151 ? 23.98813  -2.23798  13.28445  0.642 32.43132 ? 629 ARG   A HH21 1 
ATOM   5579 H HH21 B ARG   B 1 151 ? 21.47182  -1.21030  9.85695   0.358 20.51981 ? 629 ARG   A HH21 1 
ATOM   5580 H HH22 A ARG   B 1 151 ? 24.91704  -3.13943  14.02154  0.642 32.43132 ? 629 ARG   A HH22 1 
ATOM   5581 H HH22 B ARG   B 1 151 ? 21.89442  -0.50659  11.09994  0.358 20.51981 ? 629 ARG   A HH22 1 
ATOM   5582 N N    . ALA   B 1 152 ? 20.80919  -9.04357  11.22639  1.000 17.39844 ? 630 ALA   A N    1 
ATOM   5583 C CA   . ALA   B 1 152 ? 20.79383  -9.86286  12.41961  1.000 17.20063 ? 630 ALA   A CA   1 
ATOM   5584 C C    . ALA   B 1 152 ? 21.31955  -9.07016  13.60878  1.000 17.73188 ? 630 ALA   A C    1 
ATOM   5585 O O    . ALA   B 1 152 ? 22.26028  -8.27679  13.47783  1.000 19.47864 ? 630 ALA   A O    1 
ATOM   5586 C CB   . ALA   B 1 152 ? 21.64659  -11.11254 12.20851  1.000 22.02518 ? 630 ALA   A CB   1 
ATOM   5587 H H    . ALA   B 1 152 ? 21.32959  -9.32686  10.60307  1.000 20.83214 ? 630 ALA   A H    1 
ATOM   5588 H HA   . ALA   B 1 152 ? 19.88479  -10.14210 12.61085  1.000 20.59478 ? 630 ALA   A HA   1 
ATOM   5589 H HB1  . ALA   B 1 152 ? 21.62289  -11.65097 13.01500  1.000 26.38423 ? 630 ALA   A HB1  1 
ATOM   5590 H HB2  . ALA   B 1 152 ? 21.28706  -11.61792 11.46270  1.000 26.38423 ? 630 ALA   A HB2  1 
ATOM   5591 H HB3  . ALA   B 1 152 ? 22.55871  -10.84378 12.01691  1.000 26.38423 ? 630 ALA   A HB3  1 
ATOM   5592 N N    . GLY   B 1 153 ? 20.68876  -9.27309  14.76810  1.000 17.93845 ? 631 GLY   A N    1 
ATOM   5593 C CA   . GLY   B 1 153 ? 21.16462  -8.68616  16.00420  1.000 21.44081 ? 631 GLY   A CA   1 
ATOM   5594 C C    . GLY   B 1 153 ? 20.58804  -7.32722  16.37523  1.000 20.71494 ? 631 GLY   A C    1 
ATOM   5595 O O    . GLY   B 1 153 ? 20.81631  -6.86122  17.49894  1.000 21.43463 ? 631 GLY   A O    1 
ATOM   5596 H H    . GLY   B 1 153 ? 19.97936  -9.75114  14.85644  1.000 21.48016 ? 631 GLY   A H    1 
ATOM   5597 H HA2  . GLY   B 1 153 ? 20.95781  -9.29569  16.72987  1.000 25.68299 ? 631 GLY   A HA2  1 
ATOM   5598 H HA3  . GLY   B 1 153 ? 22.12726  -8.58437  15.94192  1.000 25.68299 ? 631 GLY   A HA3  1 
ATOM   5599 N N    . LEU   B 1 154 ? 19.85573  -6.67024  15.48611  1.000 16.88287 ? 632 LEU   A N    1 
ATOM   5600 C CA   . LEU   B 1 154 ? 19.20327  -5.42311  15.86321  1.000 17.10848 ? 632 LEU   A CA   1 
ATOM   5601 C C    . LEU   B 1 154 ? 18.26245  -5.65151  17.04261  1.000 18.10687 ? 632 LEU   A C    1 
ATOM   5602 O O    . LEU   B 1 154 ? 17.57819  -6.67942  17.12515  1.000 16.95622 ? 632 LEU   A O    1 
ATOM   5603 C CB   . LEU   B 1 154 ? 18.42037  -4.84658  14.69700  1.000 16.59400 ? 632 LEU   A CB   1 
ATOM   5604 C CG   . LEU   B 1 154 ? 19.19001  -4.40302  13.46855  1.000 18.97295 ? 632 LEU   A CG   1 
ATOM   5605 C CD1  . LEU   B 1 154 ? 18.25262  -3.97687  12.37207  1.000 20.83401 ? 632 LEU   A CD1  1 
ATOM   5606 C CD2  . LEU   B 1 154 ? 20.12607  -3.27145  13.83820  1.000 18.56637 ? 632 LEU   A CD2  1 
ATOM   5607 H H    . LEU   B 1 154 ? 19.72259  -6.91909  14.67374  1.000 20.21346 ? 632 LEU   A H    1 
ATOM   5608 H HA   . LEU   B 1 154 ? 19.88338  -4.78024  16.11827  1.000 20.48420 ? 632 LEU   A HA   1 
ATOM   5609 H HB2  . LEU   B 1 154 ? 17.79175  -5.52368  14.40160  1.000 19.86681 ? 632 LEU   A HB2  1 
ATOM   5610 H HB3  . LEU   B 1 154 ? 17.94127  -4.06784  15.02094  1.000 19.86681 ? 632 LEU   A HB3  1 
ATOM   5611 H HG   . LEU   B 1 154 ? 19.71384  -5.14637  13.13102  1.000 22.72156 ? 632 LEU   A HG   1 
ATOM   5612 H HD11 . LEU   B 1 154 ? 18.77287  -3.70210  11.60087  1.000 24.95483 ? 632 LEU   A HD11 1 
ATOM   5613 H HD12 . LEU   B 1 154 ? 17.68154  -4.72469  12.13642  1.000 24.95483 ? 632 LEU   A HD12 1 
ATOM   5614 H HD13 . LEU   B 1 154 ? 17.71305  -3.23541  12.68829  1.000 24.95483 ? 632 LEU   A HD13 1 
ATOM   5615 H HD21 . LEU   B 1 154 ? 20.52641  -2.91578  13.02942  1.000 22.23365 ? 632 LEU   A HD21 1 
ATOM   5616 H HD22 . LEU   B 1 154 ? 19.62015  -2.57775  14.28955  1.000 22.23365 ? 632 LEU   A HD22 1 
ATOM   5617 H HD23 . LEU   B 1 154 ? 20.81727  -3.61290  14.42689  1.000 22.23365 ? 632 LEU   A HD23 1 
ATOM   5618 N N    . VAL   B 1 155 ? 18.28775  -4.71134  17.99258  1.000 19.61148 ? 633 VAL   A N    1 
ATOM   5619 C CA   . VAL   B 1 155 ? 17.31217  -4.67947  19.07564  1.000 18.18730 ? 633 VAL   A CA   1 
ATOM   5620 C C    . VAL   B 1 155 ? 16.30325  -3.53302  18.91518  1.000 18.89121 ? 633 VAL   A C    1 
ATOM   5621 O O    . VAL   B 1 155 ? 15.25125  -3.55387  19.58254  1.000 19.19192 ? 633 VAL   A O    1 
ATOM   5622 C CB   . VAL   B 1 155 ? 17.99683  -4.58782  20.45626  1.000 22.21591 ? 633 VAL   A CB   1 
ATOM   5623 C CG1  . VAL   B 1 155 ? 18.83114  -5.82486  20.71818  1.000 23.96267 ? 633 VAL   A CG1  1 
ATOM   5624 C CG2  . VAL   B 1 155 ? 18.79720  -3.33743  20.55774  1.000 21.74840 ? 633 VAL   A CG2  1 
ATOM   5625 H H    . VAL   B 1 155 ? 18.86715  -4.07684  18.02851  1.000 23.48778 ? 633 VAL   A H    1 
ATOM   5626 H HA   . VAL   B 1 155 ? 16.81534  -5.51239  19.05823  1.000 21.77877 ? 633 VAL   A HA   1 
ATOM   5627 H HB   . VAL   B 1 155 ? 17.32062  -4.54982  21.15065  1.000 26.61311 ? 633 VAL   A HB   1 
ATOM   5628 H HG11 . VAL   B 1 155 ? 19.23484  -5.75320  21.59727  1.000 28.70922 ? 633 VAL   A HG11 1 
ATOM   5629 H HG12 . VAL   B 1 155 ? 18.25777  -6.60634  20.68021  1.000 28.70922 ? 633 VAL   A HG12 1 
ATOM   5630 H HG13 . VAL   B 1 155 ? 19.52257  -5.88868  20.04087  1.000 28.70922 ? 633 VAL   A HG13 1 
ATOM   5631 H HG21 . VAL   B 1 155 ? 19.24112  -3.31572  21.41993  1.000 26.05210 ? 633 VAL   A HG21 1 
ATOM   5632 H HG22 . VAL   B 1 155 ? 19.45616  -3.32563  19.84603  1.000 26.05210 ? 633 VAL   A HG22 1 
ATOM   5633 H HG23 . VAL   B 1 155 ? 18.20390  -2.57486  20.47187  1.000 26.05210 ? 633 VAL   A HG23 1 
ATOM   5634 N N    . THR   B 1 156 ? 16.59831  -2.53986  18.09674  1.000 18.80614 ? 634 THR   A N    1 
ATOM   5635 C CA   . THR   B 1 156 ? 15.70279  -1.46534  17.68947  1.000 18.50293 ? 634 THR   A CA   1 
ATOM   5636 C C    . THR   B 1 156 ? 16.00951  -1.19386  16.22434  1.000 18.96359 ? 634 THR   A C    1 
ATOM   5637 O O    . THR   B 1 156 ? 17.06694  -1.61639  15.72978  1.000 19.78283 ? 634 THR   A O    1 
ATOM   5638 C CB   . THR   B 1 156 ? 15.91323  -0.20075  18.50946  1.000 21.00901 ? 634 THR   A CB   1 
ATOM   5639 O OG1  . THR   B 1 156 ? 17.23719  0.27985   18.23013  1.000 25.33042 ? 634 THR   A OG1  1 
ATOM   5640 C CG2  . THR   B 1 156 ? 15.78249  -0.47873  19.98747  1.000 19.67754 ? 634 THR   A CG2  1 
ATOM   5641 H H    . THR   B 1 156 ? 17.37260  -2.45532  17.73215  1.000 22.52139 ? 634 THR   A H    1 
ATOM   5642 H HA   . THR   B 1 156 ? 14.77666  -1.72198  17.82106  1.000 22.15753 ? 634 THR   A HA   1 
ATOM   5643 H HB   . THR   B 1 156 ? 15.24509  0.46471   18.28220  1.000 25.16483 ? 634 THR   A HB   1 
ATOM   5644 H HG1  . THR   B 1 156 ? 17.38709  0.98030   18.66889  1.000 30.35052 ? 634 THR   A HG1  1 
ATOM   5645 H HG21 . THR   B 1 156 ? 15.84437  0.35005   20.48766  1.000 23.56706 ? 634 THR   A HG21 1 
ATOM   5646 H HG22 . THR   B 1 156 ? 14.92595  -0.89477  20.17230  1.000 23.56706 ? 634 THR   A HG22 1 
ATOM   5647 H HG23 . THR   B 1 156 ? 16.49094  -1.07474  20.27689  1.000 23.56706 ? 634 THR   A HG23 1 
ATOM   5648 N N    . PRO   B 1 157 ? 15.15302  -0.48148  15.49875  1.000 17.25495 ? 635 PRO   A N    1 
ATOM   5649 C CA   . PRO   B 1 157 ? 15.50235  -0.12152  14.13182  1.000 18.95336 ? 635 PRO   A CA   1 
ATOM   5650 C C    . PRO   B 1 157 ? 16.73038  0.76420   14.13202  1.000 19.01749 ? 635 PRO   A C    1 
ATOM   5651 O O    . PRO   B 1 157 ? 17.00702  1.45593   15.12518  1.000 19.78319 ? 635 PRO   A O    1 
ATOM   5652 C CB   . PRO   B 1 157 ? 14.26266  0.63887   13.63674  1.000 19.12350 ? 635 PRO   A CB   1 
ATOM   5653 C CG   . PRO   B 1 157 ? 13.14634  0.20697   14.56862  1.000 21.64116 ? 635 PRO   A CG   1 
ATOM   5654 C CD   . PRO   B 1 157 ? 13.81191  0.01874   15.88864  1.000 19.84909 ? 635 PRO   A CD   1 
ATOM   5655 H HA   . PRO   B 1 157 ? 15.64801  -0.90735  13.58214  1.000 22.69805 ? 635 PRO   A HA   1 
ATOM   5656 H HB2  . PRO   B 1 157 ? 14.41513  1.59498   13.69608  1.000 22.90221 ? 635 PRO   A HB2  1 
ATOM   5657 H HB3  . PRO   B 1 157 ? 14.06622  0.39053   12.71987  1.000 22.90221 ? 635 PRO   A HB3  1 
ATOM   5658 H HG2  . PRO   B 1 157 ? 12.46722  0.89792   14.61640  1.000 25.92341 ? 635 PRO   A HG2  1 
ATOM   5659 H HG3  . PRO   B 1 157 ? 12.75390  -0.62281  14.25500  1.000 25.92341 ? 635 PRO   A HG3  1 
ATOM   5660 H HD2  . PRO   B 1 157 ? 13.87892  0.85902   16.36856  1.000 23.77292 ? 635 PRO   A HD2  1 
ATOM   5661 H HD3  . PRO   B 1 157 ? 13.33909  -0.63446  16.42778  1.000 23.77292 ? 635 PRO   A HD3  1 
ATOM   5662 N N    . PRO   B 1 158 ? 17.48545  0.78665   13.03425  1.000 18.82895 ? 636 PRO   A N    1 
ATOM   5663 C CA   . PRO   B 1 158 ? 18.63503  1.67044   12.93229  1.000 22.61317 ? 636 PRO   A CA   1 
ATOM   5664 C C    . PRO   B 1 158 ? 18.23798  3.13773   12.97811  1.000 20.81004 ? 636 PRO   A C    1 
ATOM   5665 O O    . PRO   B 1 158 ? 17.10376  3.51231   12.68093  1.000 18.76898 ? 636 PRO   A O    1 
ATOM   5666 C CB   . PRO   B 1 158 ? 19.23652  1.31656   11.55767  1.000 22.27304 ? 636 PRO   A CB   1 
ATOM   5667 C CG   . PRO   B 1 158 ? 18.68648  -0.03416  11.21828  1.000 24.31143 ? 636 PRO   A CG   1 
ATOM   5668 C CD   . PRO   B 1 158 ? 17.32625  -0.07097  11.84011  1.000 20.82936 ? 636 PRO   A CD   1 
ATOM   5669 H HA   . PRO   B 1 158 ? 19.26493  1.47934   13.64475  1.000 27.08982 ? 636 PRO   A HA   1 
ATOM   5670 H HB2  . PRO   B 1 158 ? 18.96403  1.97582   10.90038  1.000 26.68167 ? 636 PRO   A HB2  1 
ATOM   5671 H HB3  . PRO   B 1 158 ? 20.20418  1.29009   11.61956  1.000 26.68167 ? 636 PRO   A HB3  1 
ATOM   5672 H HG2  . PRO   B 1 158 ? 18.62945  -0.13462  10.25518  1.000 29.12773 ? 636 PRO   A HG2  1 
ATOM   5673 H HG3  . PRO   B 1 158 ? 19.25601  -0.72537  11.59079  1.000 29.12773 ? 636 PRO   A HG3  1 
ATOM   5674 H HD2  . PRO   B 1 158 ? 16.65958  0.29411   11.23748  1.000 24.94925 ? 636 PRO   A HD2  1 
ATOM   5675 H HD3  . PRO   B 1 158 ? 17.08498  -0.97585  12.09284  1.000 24.94925 ? 636 PRO   A HD3  1 
ATOM   5676 N N    . PRO   B 1 159 ? 19.17908  4.02782   13.27561  1.000 22.92858 ? 637 PRO   A N    1 
ATOM   5677 C CA   . PRO   B 1 159 ? 18.88033  5.45611   13.15631  1.000 22.62895 ? 637 PRO   A CA   1 
ATOM   5678 C C    . PRO   B 1 159 ? 18.75712  5.88790   11.70057  1.000 26.34350 ? 637 PRO   A C    1 
ATOM   5679 O O    . PRO   B 1 159 ? 19.40220  5.35289   10.80790  1.000 28.53265 ? 637 PRO   A O    1 
ATOM   5680 C CB   . PRO   B 1 159 ? 20.08524  6.12774   13.83119  1.000 29.91327 ? 637 PRO   A CB   1 
ATOM   5681 C CG   . PRO   B 1 159 ? 21.19054  5.12520   13.72873  1.000 31.69794 ? 637 PRO   A CG   1 
ATOM   5682 C CD   . PRO   B 1 159 ? 20.54955  3.75700   13.76232  1.000 25.22371 ? 637 PRO   A CD   1 
ATOM   5683 H HA   . PRO   B 1 159 ? 18.06554  5.67854   13.63332  1.000 27.10876 ? 637 PRO   A HA   1 
ATOM   5684 H HB2  . PRO   B 1 159 ? 20.31332  6.94573   13.36240  1.000 35.84994 ? 637 PRO   A HB2  1 
ATOM   5685 H HB3  . PRO   B 1 159 ? 19.87827  6.32343   14.75842  1.000 35.84994 ? 637 PRO   A HB3  1 
ATOM   5686 H HG2  . PRO   B 1 159 ? 21.66826  5.25583   12.89469  1.000 37.99155 ? 637 PRO   A HG2  1 
ATOM   5687 H HG3  . PRO   B 1 159 ? 21.79604  5.23485   14.47856  1.000 37.99155 ? 637 PRO   A HG3  1 
ATOM   5688 H HD2  . PRO   B 1 159 ? 21.01257  3.14177   13.17239  1.000 30.22247 ? 637 PRO   A HD2  1 
ATOM   5689 H HD3  . PRO   B 1 159 ? 20.53398  3.40264   14.66514  1.000 30.22247 ? 637 PRO   A HD3  1 
ATOM   5690 N N    . LYS   B 1 160 ? 17.89427  6.86083   11.46013  1.000 26.20429 ? 638 LYS   A N    1 
ATOM   5691 C CA   . LYS   B 1 160 ? 17.80070  7.43609   10.12578  1.000 35.10572 ? 638 LYS   A CA   1 
ATOM   5692 C C    . LYS   B 1 160 ? 19.10885  8.10841   9.71241   1.000 46.24077 ? 638 LYS   A C    1 
ATOM   5693 O O    . LYS   B 1 160 ? 19.46402  8.10743   8.53135   1.000 52.46153 ? 638 LYS   A O    1 
ATOM   5694 C CB   . LYS   B 1 160 ? 16.67131  8.45321   10.06531  1.000 34.01025 ? 638 LYS   A CB   1 
ATOM   5695 C CG   . LYS   B 1 160 ? 15.29189  7.84184   9.94693   1.000 33.18594 ? 638 LYS   A CG   1 
ATOM   5696 C CD   . LYS   B 1 160 ? 14.24008  8.92655   10.00064  1.000 39.13890 ? 638 LYS   A CD   1 
ATOM   5697 C CE   . LYS   B 1 160 ? 12.85735  8.33814   9.92901   1.000 33.49523 ? 638 LYS   A CE   1 
ATOM   5698 N NZ   . LYS   B 1 160 ? 11.82925  9.31625   10.43634  1.000 37.85174 ? 638 LYS   A NZ   1 
ATOM   5699 H H    . LYS   B 1 160 ? 17.35911  7.20244   12.04022  1.000 31.39917 ? 638 LYS   A H    1 
ATOM   5700 H HA   . LYS   B 1 160 ? 17.60465  6.72114   9.50023   1.000 42.08088 ? 638 LYS   A HA   1 
ATOM   5701 H HB2  . LYS   B 1 160 ? 16.68898  8.98484   10.87645  1.000 40.76631 ? 638 LYS   A HB2  1 
ATOM   5702 H HB3  . LYS   B 1 160 ? 16.80807  9.02288   9.29222   1.000 40.76631 ? 638 LYS   A HB3  1 
ATOM   5703 H HG2  . LYS   B 1 160 ? 15.21314  7.37348   9.10116   1.000 39.77714 ? 638 LYS   A HG2  1 
ATOM   5704 H HG3  . LYS   B 1 160 ? 15.14252  7.22674   10.68195  1.000 39.77714 ? 638 LYS   A HG3  1 
ATOM   5705 H HD2  . LYS   B 1 160 ? 14.32279  9.41640   10.83377  1.000 46.92069 ? 638 LYS   A HD2  1 
ATOM   5706 H HD3  . LYS   B 1 160 ? 14.35727  9.52830   9.24893   1.000 46.92069 ? 638 LYS   A HD3  1 
ATOM   5707 H HE2  . LYS   B 1 160 ? 12.64605  8.12018   9.00774   1.000 40.14830 ? 638 LYS   A HE2  1 
ATOM   5708 H HE3  . LYS   B 1 160 ? 12.81749  7.53850   10.47664  1.000 40.14830 ? 638 LYS   A HE3  1 
ATOM   5709 H HZ1  . LYS   B 1 160 ? 11.84504  10.05734  9.94375   1.000 45.37611 ? 638 LYS   A HZ1  1 
ATOM   5710 H HZ2  . LYS   B 1 160 ? 11.01692  8.95564   10.38961  1.000 45.37611 ? 638 LYS   A HZ2  1 
ATOM   5711 H HZ3  . LYS   B 1 160 ? 12.00279  9.52848   11.28306  1.000 45.37611 ? 638 LYS   A HZ3  1 
ATOM   5712 N N    . ASN   B 1 161 ? 19.83650  8.67765   10.66754  1.000 50.56490 ? 639 ASN   A N    1 
ATOM   5713 C CA   . ASN   B 1 161 ? 21.06950  9.38043   10.39262  1.000 53.83288 ? 639 ASN   A CA   1 
ATOM   5714 C C    . ASN   B 1 161 ? 22.01362  9.15729   11.56474  1.000 52.92488 ? 639 ASN   A C    1 
ATOM   5715 O O    . ASN   B 1 161 ? 21.63221  9.43514   12.71151  1.000 48.66750 ? 639 ASN   A O    1 
ATOM   5716 C CB   . ASN   B 1 161 ? 20.81061  10.87358  10.19195  1.000 54.00977 ? 639 ASN   A CB   1 
ATOM   5717 C CG   . ASN   B 1 161 ? 22.03096  11.60914  9.66584   1.000 66.79247 ? 639 ASN   A CG   1 
ATOM   5718 O OD1  . ASN   B 1 161 ? 23.17716  11.24434  9.96844   1.000 61.03243 ? 639 ASN   A OD1  1 
ATOM   5719 N ND2  . ASN   B 1 161 ? 21.79356  12.64568  8.87027   1.000 58.65617 ? 639 ASN   A ND2  1 
ATOM   5720 H H    . ASN   B 1 161 ? 19.62648  8.66676   11.50143  1.000 60.63189 ? 639 ASN   A H    1 
ATOM   5721 H HA   . ASN   B 1 161 ? 21.48992  9.01998   9.59624   1.000 64.55347 ? 639 ASN   A HA   1 
ATOM   5722 H HB2  . ASN   B 1 161 ? 20.09109  10.98744  9.55146   1.000 64.76573 ? 639 ASN   A HB2  1 
ATOM   5723 H HB3  . ASN   B 1 161 ? 20.56365  11.26973  11.04224  1.000 64.76573 ? 639 ASN   A HB3  1 
ATOM   5724 H HD21 . ASN   B 1 161 ? 22.44930  13.09703  8.54485   1.000 70.34141 ? 639 ASN   A HD21 1 
ATOM   5725 H HD22 . ASN   B 1 161 ? 20.98409  12.86556  8.68049   1.000 70.34141 ? 639 ASN   A HD22 1 
ATOM   5726 N N    . PRO   B 1 162 ? 23.22906  8.66279   11.32518  1.000 63.06851 ? 640 PRO   A N    1 
ATOM   5727 C CA   . PRO   B 1 162 ? 24.18034  8.50131   12.44438  1.000 65.16404 ? 640 PRO   A CA   1 
ATOM   5728 C C    . PRO   B 1 162 ? 24.45344  9.78707   13.21135  1.000 62.10698 ? 640 PRO   A C    1 
ATOM   5729 O O    . PRO   B 1 162 ? 24.97497  9.71577   14.33077  1.000 56.85430 ? 640 PRO   A O    1 
ATOM   5730 C CB   . PRO   B 1 162 ? 25.45453  7.98756   11.75764  1.000 68.52608 ? 640 PRO   A CB   1 
ATOM   5731 C CG   . PRO   B 1 162 ? 24.96918  7.33420   10.49994  1.000 65.34229 ? 640 PRO   A CG   1 
ATOM   5732 C CD   . PRO   B 1 162 ? 23.76950  8.14162   10.05298  1.000 59.90276 ? 640 PRO   A CD   1 
ATOM   5733 H HA   . PRO   B 1 162 ? 23.84885  7.82685   13.05766  1.000 78.15086 ? 640 PRO   A HA   1 
ATOM   5734 H HB2  . PRO   B 1 162 ? 26.04641  8.72986   11.55872  1.000 82.18532 ? 640 PRO   A HB2  1 
ATOM   5735 H HB3  . PRO   B 1 162 ? 25.90547  7.34810   12.33092  1.000 82.18532 ? 640 PRO   A HB3  1 
ATOM   5736 H HG2  . PRO   B 1 162 ? 25.66855  7.35703   9.82819   1.000 78.36477 ? 640 PRO   A HG2  1 
ATOM   5737 H HG3  . PRO   B 1 162 ? 24.71626  6.41611   10.68448  1.000 78.36477 ? 640 PRO   A HG3  1 
ATOM   5738 H HD2  . PRO   B 1 162 ? 24.03841  8.86687   9.46766   1.000 71.83732 ? 640 PRO   A HD2  1 
ATOM   5739 H HD3  . PRO   B 1 162 ? 23.11944  7.57770   9.60540   1.000 71.83732 ? 640 PRO   A HD3  1 
ATOM   5740 N N    . HIS   B 1 163 ? 24.11568  10.95496  12.64935  1.000 61.11549 ? 641 HIS   A N    1 
ATOM   5741 C CA   . HIS   B 1 163 ? 24.31756  12.21545  13.35820  1.000 57.77643 ? 641 HIS   A CA   1 
ATOM   5742 C C    . HIS   B 1 163 ? 23.28863  12.43702  14.45496  1.000 58.33763 ? 641 HIS   A C    1 
ATOM   5743 O O    . HIS   B 1 163 ? 23.55010  13.21547  15.37719  1.000 62.25582 ? 641 HIS   A O    1 
ATOM   5744 C CB   . HIS   B 1 163 ? 24.26975  13.37898  12.36922  1.000 65.85189 ? 641 HIS   A CB   1 
ATOM   5745 C CG   . HIS   B 1 163 ? 25.31181  13.29471  11.29465  1.000 75.59216 ? 641 HIS   A CG   1 
ATOM   5746 N ND1  . HIS   B 1 163 ? 26.46664  12.55271  11.43706  1.000 68.07340 ? 641 HIS   A ND1  1 
ATOM   5747 C CD2  . HIS   B 1 163 ? 25.37211  13.85313  10.06124  1.000 77.67372 ? 641 HIS   A CD2  1 
ATOM   5748 C CE1  . HIS   B 1 163 ? 27.19333  12.65861  10.33923  1.000 74.94619 ? 641 HIS   A CE1  1 
ATOM   5749 N NE2  . HIS   B 1 163 ? 26.55014  13.43861  9.48722   1.000 80.40236 ? 641 HIS   A NE2  1 
ATOM   5750 H H    . HIS   B 1 163 ? 23.77134  11.03986  11.86588  1.000 73.29260 ? 641 HIS   A H    1 
ATOM   5751 H HA   . HIS   B 1 163 ? 25.19474  12.20025  13.77200  1.000 69.28573 ? 641 HIS   A HA   1 
ATOM   5752 H HB2  . HIS   B 1 163 ? 23.40017  13.38862  11.93952  1.000 78.97629 ? 641 HIS   A HB2  1 
ATOM   5753 H HB3  . HIS   B 1 163 ? 24.40943  14.20743  12.85405  1.000 78.97629 ? 641 HIS   A HB3  1 
ATOM   5754 H HD2  . HIS   B 1 163 ? 24.73614  14.41162  9.67584   1.000 93.16248 ? 641 HIS   A HD2  1 
ATOM   5755 H HE1  . HIS   B 1 163 ? 28.01718  12.25348  10.19081  1.000 89.88944 ? 641 HIS   A HE1  1 
ATOM   5756 H HE2  . HIS   B 1 163 ? 26.82462  13.65218  8.70068   1.000 96.43684 ? 641 HIS   A HE2  1 
ATOM   5757 N N    . ASN   B 1 164 ? 22.12104  11.79013  14.36814  1.000 59.35589 ? 642 ASN   A N    1 
ATOM   5758 C CA   . ASN   B 1 164 ? 21.09393  11.82652  15.41317  1.000 51.74382 ? 642 ASN   A CA   1 
ATOM   5759 C C    . ASN   B 1 164 ? 20.72966  10.38391  15.73701  1.000 46.18301 ? 642 ASN   A C    1 
ATOM   5760 O O    . ASN   B 1 164 ? 19.71368  9.86149   15.25447  1.000 43.22748 ? 642 ASN   A O    1 
ATOM   5761 C CB   . ASN   B 1 164 ? 19.87158  12.62696  14.97021  1.000 46.06416 ? 642 ASN   A CB   1 
ATOM   5762 C CG   . ASN   B 1 164 ? 18.85301  12.79354  16.08166  1.000 55.68241 ? 642 ASN   A CG   1 
ATOM   5763 O OD1  . ASN   B 1 164 ? 19.06130  12.33350  17.21417  1.000 51.59304 ? 642 ASN   A OD1  1 
ATOM   5764 N ND2  . ASN   B 1 164 ? 17.74010  13.46196  15.76860  1.000 55.13845 ? 642 ASN   A ND2  1 
ATOM   5765 H H    . ASN   B 1 164 ? 21.89550  11.30910  13.69187  1.000 71.18108 ? 642 ASN   A H    1 
ATOM   5766 H HA   . ASN   B 1 164 ? 21.44813  12.25090  16.21026  1.000 62.04660 ? 642 ASN   A HA   1 
ATOM   5767 H HB2  . ASN   B 1 164 ? 20.15622  13.51022  14.68785  1.000 55.23100 ? 642 ASN   A HB2  1 
ATOM   5768 H HB3  . ASN   B 1 164 ? 19.44062  12.16600  14.23353  1.000 55.23100 ? 642 ASN   A HB3  1 
ATOM   5769 H HD21 . ASN   B 1 164 ? 17.13047  13.58430  16.36273  1.000 66.12016 ? 642 ASN   A HD21 1 
ATOM   5770 H HD22 . ASN   B 1 164 ? 17.63302  13.77007  14.97286  1.000 66.12016 ? 642 ASN   A HD22 1 
ATOM   5771 N N    . PRO   B 1 165 ? 21.54472  9.70632   16.54865  1.000 42.88921 ? 643 PRO   A N    1 
ATOM   5772 C CA   . PRO   B 1 165 ? 21.35955  8.26208   16.73311  1.000 40.79779 ? 643 PRO   A CA   1 
ATOM   5773 C C    . PRO   B 1 165 ? 20.04167  7.88195   17.38031  1.000 41.12410 ? 643 PRO   A C    1 
ATOM   5774 O O    . PRO   B 1 165 ? 19.73251  6.68682   17.39405  1.000 30.70989 ? 643 PRO   A O    1 
ATOM   5775 C CB   . PRO   B 1 165 ? 22.53953  7.85678   17.63008  1.000 40.76421 ? 643 PRO   A CB   1 
ATOM   5776 C CG   . PRO   B 1 165 ? 23.54714  8.95393   17.47012  1.000 40.70515 ? 643 PRO   A CG   1 
ATOM   5777 C CD   . PRO   B 1 165 ? 22.74695  10.20742  17.23729  1.000 42.00598 ? 643 PRO   A CD   1 
ATOM   5778 H HA   . PRO   B 1 165 ? 21.43639  7.81736   15.87449  1.000 48.91137 ? 643 PRO   A HA   1 
ATOM   5779 H HB2  . PRO   B 1 165 ? 22.24474  7.78849   18.55168  1.000 48.87106 ? 643 PRO   A HB2  1 
ATOM   5780 H HB3  . PRO   B 1 165 ? 22.90209  7.00723   17.33392  1.000 48.87106 ? 643 PRO   A HB3  1 
ATOM   5781 H HG2  . PRO   B 1 165 ? 24.08005  9.03033   18.27701  1.000 48.80019 ? 643 PRO   A HG2  1 
ATOM   5782 H HG3  . PRO   B 1 165 ? 24.12025  8.76504   16.71067  1.000 48.80019 ? 643 PRO   A HG3  1 
ATOM   5783 H HD2  . PRO   B 1 165 ? 22.51373  10.63119  18.07808  1.000 50.36119 ? 643 PRO   A HD2  1 
ATOM   5784 H HD3  . PRO   B 1 165 ? 23.23400  10.83048  16.67562  1.000 50.36119 ? 643 PRO   A HD3  1 
ATOM   5785 N N    . THR   B 1 166 ? 19.27463  8.83955   17.92282  1.000 36.31937 ? 644 THR   A N    1 
ATOM   5786 C CA   . THR   B 1 166 ? 18.02208  8.51472   18.60162  1.000 33.38807 ? 644 THR   A CA   1 
ATOM   5787 C C    . THR   B 1 166 ? 16.79279  8.65836   17.71982  1.000 29.10540 ? 644 THR   A C    1 
ATOM   5788 O O    . THR   B 1 166 ? 15.71252  8.20543   18.12294  1.000 26.40917 ? 644 THR   A O    1 
ATOM   5789 C CB   . THR   B 1 166 ? 17.84382  9.39789   19.84359  1.000 38.99323 ? 644 THR   A CB   1 
ATOM   5790 O OG1  . THR   B 1 166 ? 17.87709  10.77540  19.44331  1.000 41.28507 ? 644 THR   A OG1  1 
ATOM   5791 C CG2  . THR   B 1 166 ? 18.94288  9.08975   20.87594  1.000 31.46026 ? 644 THR   A CG2  1 
ATOM   5792 H H    . THR   B 1 166 ? 19.46196  9.67877   17.90800  1.000 43.53726 ? 644 THR   A H    1 
ATOM   5793 H HA   . THR   B 1 166 ? 18.07155  7.58982   18.88973  1.000 40.01970 ? 644 THR   A HA   1 
ATOM   5794 H HB   . THR   B 1 166 ? 16.99188  9.22236   20.27287  1.000 46.74589 ? 644 THR   A HB   1 
ATOM   5795 H HG1  . THR   B 1 166 ? 17.77222  11.27174  20.11283  1.000 49.49610 ? 644 THR   A HG1  1 
ATOM   5796 H HG21 . THR   B 1 166 ? 18.81672  9.63562   21.66778  1.000 37.70632 ? 644 THR   A HG21 1 
ATOM   5797 H HG22 . THR   B 1 166 ? 18.90694  8.15418   21.12954  1.000 37.70632 ? 644 THR   A HG22 1 
ATOM   5798 H HG23 . THR   B 1 166 ? 19.81574  9.28019   20.49810  1.000 37.70632 ? 644 THR   A HG23 1 
ATOM   5799 N N    . ASP   B 1 167 ? 16.90961  9.29321   16.55875  1.000 31.52173 ? 645 ASP   A N    1 
ATOM   5800 C CA   . ASP   B 1 167 ? 15.80576  9.42837   15.60805  1.000 32.38460 ? 645 ASP   A CA   1 
ATOM   5801 C C    . ASP   B 1 167 ? 15.80445  8.18339   14.72042  1.000 27.50414 ? 645 ASP   A C    1 
ATOM   5802 O O    . ASP   B 1 167 ? 16.63687  8.04076   13.82135  1.000 28.37454 ? 645 ASP   A O    1 
ATOM   5803 C CB   . ASP   B 1 167 ? 15.96200  10.70167  14.78565  1.000 38.66140 ? 645 ASP   A CB   1 
ATOM   5804 C CG   . ASP   B 1 167 ? 14.72230  11.02782  13.97704  1.000 44.93412 ? 645 ASP   A CG   1 
ATOM   5805 O OD1  . ASP   B 1 167 ? 13.65987  10.43299  14.23831  1.000 40.44646 ? 645 ASP   A OD1  1 
ATOM   5806 O OD2  . ASP   B 1 167 ? 14.81734  11.87353  13.06165  1.000 45.82388 ? 645 ASP   A OD2  1 
ATOM   5807 H H    . ASP   B 1 167 ? 17.63686  9.66497   16.28947  1.000 37.78009 ? 645 ASP   A H    1 
ATOM   5808 H HA   . ASP   B 1 167 ? 14.96235  9.47470   16.08493  1.000 38.81553 ? 645 ASP   A HA   1 
ATOM   5809 H HB2  . ASP   B 1 167 ? 16.13544  11.44562  15.38344  1.000 46.34769 ? 645 ASP   A HB2  1 
ATOM   5810 H HB3  . ASP   B 1 167 ? 16.70281  10.59174  14.16919  1.000 46.34769 ? 645 ASP   A HB3  1 
ATOM   5811 N N    . LEU   B 1 168 ? 14.87469  7.26496   14.98471  1.000 26.07240 ? 646 LEU   A N    1 
ATOM   5812 C CA   . LEU   B 1 168 ? 14.95846  5.91276   14.43930  1.000 21.30416 ? 646 LEU   A CA   1 
ATOM   5813 C C    . LEU   B 1 168 ? 13.96252  5.68593   13.31084  1.000 21.73315 ? 646 LEU   A C    1 
ATOM   5814 O O    . LEU   B 1 168 ? 12.90601  6.29821   13.26750  1.000 19.33185 ? 646 LEU   A O    1 
ATOM   5815 C CB   . LEU   B 1 168 ? 14.70899  4.88362   15.52570  1.000 20.57091 ? 646 LEU   A CB   1 
ATOM   5816 C CG   . LEU   B 1 168 ? 15.52536  5.01972   16.81575  1.000 22.58955 ? 646 LEU   A CG   1 
ATOM   5817 C CD1  . LEU   B 1 168 ? 15.12104  3.91737   17.78618  1.000 25.15614 ? 646 LEU   A CD1  1 
ATOM   5818 C CD2  . LEU   B 1 168 ? 16.99788  4.96276   16.51239  1.000 25.80799 ? 646 LEU   A CD2  1 
ATOM   5819 H H    . LEU   B 1 168 ? 14.18468  7.40350   15.47897  1.000 31.24090 ? 646 LEU   A H    1 
ATOM   5820 H HA   . LEU   B 1 168 ? 15.84663  5.79299   14.06821  1.000 25.51901 ? 646 LEU   A HA   1 
ATOM   5821 H HB2  . LEU   B 1 168 ? 13.77341  4.93554   15.77649  1.000 24.63910 ? 646 LEU   A HB2  1 
ATOM   5822 H HB3  . LEU   B 1 168 ? 14.90574  4.00793   15.15779  1.000 24.63910 ? 646 LEU   A HB3  1 
ATOM   5823 H HG   . LEU   B 1 168 ? 15.34884  5.87713   17.23358  1.000 27.06147 ? 646 LEU   A HG   1 
ATOM   5824 H HD11 . LEU   B 1 168 ? 15.63891  4.00859   18.60128  1.000 30.14138 ? 646 LEU   A HD11 1 
ATOM   5825 H HD12 . LEU   B 1 168 ? 14.17521  4.00204   17.98400  1.000 30.14138 ? 646 LEU   A HD12 1 
ATOM   5826 H HD13 . LEU   B 1 168 ? 15.29753  3.05587   17.37682  1.000 30.14138 ? 646 LEU   A HD13 1 
ATOM   5827 H HD21 . LEU   B 1 168 ? 17.49250  4.96424   17.34680  1.000 30.92360 ? 646 LEU   A HD21 1 
ATOM   5828 H HD22 . LEU   B 1 168 ? 17.18709  4.15047   16.01714  1.000 30.92360 ? 646 LEU   A HD22 1 
ATOM   5829 H HD23 . LEU   B 1 168 ? 17.24129  5.73772   15.98220  1.000 30.92360 ? 646 LEU   A HD23 1 
ATOM   5830 N N    . PHE   B 1 169 ? 14.31418  4.78987   12.39584  1.000 19.42000 ? 647 PHE   A N    1 
ATOM   5831 C CA   . PHE   B 1 169 ? 13.31018  4.20048   11.53258  1.000 18.83096 ? 647 PHE   A CA   1 
ATOM   5832 C C    . PHE   B 1 169 ? 12.23764  3.55391   12.39616  1.000 16.07236 ? 647 PHE   A C    1 
ATOM   5833 O O    . PHE   B 1 169 ? 12.49779  3.14677   13.52661  1.000 15.51410 ? 647 PHE   A O    1 
ATOM   5834 C CB   . PHE   B 1 169 ? 13.93391  3.16901   10.59814  1.000 18.11721 ? 647 PHE   A CB   1 
ATOM   5835 C CG   . PHE   B 1 169 ? 14.72040  3.78600   9.45811   1.000 18.43685 ? 647 PHE   A CG   1 
ATOM   5836 C CD1  . PHE   B 1 169 ? 14.07000  4.30040   8.36073   1.000 20.51080 ? 647 PHE   A CD1  1 
ATOM   5837 C CD2  . PHE   B 1 169 ? 16.09543  3.81651   9.48967   1.000 21.03167 ? 647 PHE   A CD2  1 
ATOM   5838 C CE1  . PHE   B 1 169 ? 14.75728  4.87572   7.32528   1.000 20.26733 ? 647 PHE   A CE1  1 
ATOM   5839 C CE2  . PHE   B 1 169 ? 16.80964  4.37103   8.43736   1.000 21.24015 ? 647 PHE   A CE2  1 
ATOM   5840 C CZ   . PHE   B 1 169 ? 16.14319  4.88566   7.36370   1.000 22.83247 ? 647 PHE   A CZ   1 
ATOM   5841 H H    . PHE   B 1 169 ? 15.11672  4.51252   12.25944  1.000 23.25801 ? 647 PHE   A H    1 
ATOM   5842 H HA   . PHE   B 1 169 ? 12.90417  4.88116   10.97335  1.000 22.55117 ? 647 PHE   A HA   1 
ATOM   5843 H HB2  . PHE   B 1 169 ? 14.53974  2.60958   11.10893  1.000 21.69467 ? 647 PHE   A HB2  1 
ATOM   5844 H HB3  . PHE   B 1 169 ? 13.22725  2.62744   10.21313  1.000 21.69467 ? 647 PHE   A HB3  1 
ATOM   5845 H HD1  . PHE   B 1 169 ? 13.14189  4.25649   8.32099   1.000 24.56698 ? 647 PHE   A HD1  1 
ATOM   5846 H HD2  . PHE   B 1 169 ? 16.54893  3.46331   10.22075  1.000 25.19202 ? 647 PHE   A HD2  1 
ATOM   5847 H HE1  . PHE   B 1 169 ? 14.30175  5.25363   6.60794   1.000 24.27481 ? 647 PHE   A HE1  1 
ATOM   5848 H HE2  . PHE   B 1 169 ? 17.73904  4.39188   8.46368   1.000 25.44220 ? 647 PHE   A HE2  1 
ATOM   5849 H HZ   . PHE   B 1 169 ? 16.62209  5.24574   6.65244   1.000 27.35298 ? 647 PHE   A HZ   1 
ATOM   5850 N N    . ASP   B 1 170 ? 11.05615  3.36074   11.81315  1.000 16.97008 ? 648 ASP   A N    1 
ATOM   5851 C CA   . ASP   B 1 170 ? 9.93437   2.76650   12.55514  1.000 14.96364 ? 648 ASP   A CA   1 
ATOM   5852 C C    . ASP   B 1 170 ? 9.90638   1.23945   12.50869  1.000 16.20956 ? 648 ASP   A C    1 
ATOM   5853 O O    . ASP   B 1 170 ? 9.37900   0.60964   13.43013  1.000 14.46284 ? 648 ASP   A O    1 
ATOM   5854 C CB   . ASP   B 1 170 ? 8.62323   3.31599   12.02059  1.000 15.76399 ? 648 ASP   A CB   1 
ATOM   5855 C CG   . ASP   B 1 170 ? 8.56130   4.84375   12.10935  1.000 18.00830 ? 648 ASP   A CG   1 
ATOM   5856 O OD1  . ASP   B 1 170 ? 8.65165   5.34544   13.23618  1.000 18.48903 ? 648 ASP   A OD1  1 
ATOM   5857 O OD2  . ASP   B 1 170 ? 8.46371   5.48237   11.04883  1.000 18.64851 ? 648 ASP   A OD2  1 
ATOM   5858 H H    . ASP   B 1 170 ? 10.87565  3.56189   10.99672  1.000 20.31811 ? 648 ASP   A H    1 
ATOM   5859 H HA   . ASP   B 1 170 ? 10.01645  3.01738   13.48854  1.000 17.91038 ? 648 ASP   A HA   1 
ATOM   5860 H HB2  . ASP   B 1 170 ? 8.52741   3.06252   11.08921  1.000 18.87081 ? 648 ASP   A HB2  1 
ATOM   5861 H HB3  . ASP   B 1 170 ? 7.88953   2.95235   12.54055  1.000 18.87081 ? 648 ASP   A HB3  1 
ATOM   5862 N N    . SER   B 1 171 ? 10.45013  0.64208   11.44644  1.000 15.30519 ? 649 SER   A N    1 
ATOM   5863 C CA   . SER   B 1 171 ? 10.50031  -0.80098  11.31274  1.000 14.55490 ? 649 SER   A CA   1 
ATOM   5864 C C    . SER   B 1 171 ? 11.63127  -1.12594  10.34582  1.000 14.87940 ? 649 SER   A C    1 
ATOM   5865 O O    . SER   B 1 171 ? 12.22016  -0.22594  9.74077   1.000 14.04576 ? 649 SER   A O    1 
ATOM   5866 C CB   . SER   B 1 171 ? 9.15809   -1.34773  10.83648  1.000 13.56701 ? 649 SER   A CB   1 
ATOM   5867 O OG   . SER   B 1 171 ? 8.86811   -0.98005  9.49575   1.000 14.24434 ? 649 SER   A OG   1 
ATOM   5868 H H    . SER   B 1 171 ? 10.80019  1.06312   10.78328  1.000 18.32025 ? 649 SER   A H    1 
ATOM   5869 H HA   . SER   B 1 171 ? 10.70041  -1.22061  12.16407  1.000 17.41989 ? 649 SER   A HA   1 
ATOM   5870 H HB2  . SER   B 1 171 ? 9.18042   -2.31577  10.89387  1.000 16.23443 ? 649 SER   A HB2  1 
ATOM   5871 H HB3  . SER   B 1 171 ? 8.45976   -0.99732  11.41132  1.000 16.23443 ? 649 SER   A HB3  1 
ATOM   5872 H HG   . SER   B 1 171 ? 8.83986   -0.14334  9.42700   1.000 17.04722 ? 649 SER   A HG   1 
ATOM   5873 N N    . VAL   B 1 172 ? 11.92398  -2.42179  10.20573  1.000 15.84629 ? 650 VAL   A N    1 
ATOM   5874 C CA   . VAL   B 1 172 ? 12.86436  -2.88203  9.19476   1.000 16.18585 ? 650 VAL   A CA   1 
ATOM   5875 C C    . VAL   B 1 172 ? 12.18836  -3.93352  8.33071   1.000 16.15071 ? 650 VAL   A C    1 
ATOM   5876 O O    . VAL   B 1 172 ? 11.16053  -4.49819  8.69093   1.000 15.64853 ? 650 VAL   A O    1 
ATOM   5877 C CB   . VAL   B 1 172 ? 14.17100  -3.42574  9.80380   1.000 16.63918 ? 650 VAL   A CB   1 
ATOM   5878 C CG1  . VAL   B 1 172 ? 14.83039  -2.28108  10.62863  1.000 15.84007 ? 650 VAL   A CG1  1 
ATOM   5879 C CG2  . VAL   B 1 172 ? 13.95056  -4.66470  10.63880  1.000 15.95507 ? 650 VAL   A CG2  1 
ATOM   5880 H H    . VAL   B 1 172 ? 11.58726  -3.04939  10.68775  1.000 18.96956 ? 650 VAL   A H    1 
ATOM   5881 H HA   . VAL   B 1 172 ? 13.09361  -2.13380  8.62162   1.000 19.37703 ? 650 VAL   A HA   1 
ATOM   5882 H HB   . VAL   B 1 172 ? 14.76917  -3.70586  9.09343   1.000 19.92103 ? 650 VAL   A HB   1 
ATOM   5883 H HG11 . VAL   B 1 172 ? 15.67788  -2.59407  10.98173  1.000 18.96210 ? 650 VAL   A HG11 1 
ATOM   5884 H HG12 . VAL   B 1 172 ? 14.97552  -1.51717  10.04874  1.000 18.96210 ? 650 VAL   A HG12 1 
ATOM   5885 H HG13 . VAL   B 1 172 ? 14.23888  -2.03567  11.35718  1.000 18.96210 ? 650 VAL   A HG13 1 
ATOM   5886 H HG21 . VAL   B 1 172 ? 14.78522  -4.90840  11.06874  1.000 19.10010 ? 650 VAL   A HG21 1 
ATOM   5887 H HG22 . VAL   B 1 172 ? 13.27532  -4.47746  11.30954  1.000 19.10010 ? 650 VAL   A HG22 1 
ATOM   5888 H HG23 . VAL   B 1 172 ? 13.65285  -5.38546  10.06194  1.000 19.10010 ? 650 VAL   A HG23 1 
ATOM   5889 N N    . THR   B 1 173 ? 12.82452  -4.23568  7.20017   1.000 15.51759 ? 651 THR   A N    1 
ATOM   5890 C CA   . THR   B 1 173 ? 12.29370  -5.19738  6.25235   1.000 17.60569 ? 651 THR   A CA   1 
ATOM   5891 C C    . THR   B 1 173 ? 13.44815  -5.99604  5.65058   1.000 16.36272 ? 651 THR   A C    1 
ATOM   5892 O O    . THR   B 1 173 ? 14.63309  -5.68147  5.82650   1.000 17.41366 ? 651 THR   A O    1 
ATOM   5893 C CB   . THR   B 1 173 ? 11.48630  -4.49302  5.14908   1.000 18.21494 ? 651 THR   A CB   1 
ATOM   5894 O OG1  . THR   B 1 173 ? 10.92058  -5.45333  4.26427   1.000 17.70082 ? 651 THR   A OG1  1 
ATOM   5895 C CG2  . THR   B 1 173 ? 12.37394  -3.54486  4.35057   1.000 19.26325 ? 651 THR   A CG2  1 
ATOM   5896 H H    . THR   B 1 173 ? 13.57471  -3.88941  6.96162   1.000 18.57513 ? 651 THR   A H    1 
ATOM   5897 H HA   . THR   B 1 173 ? 11.70947  -5.81962  6.71322   1.000 21.08084 ? 651 THR   A HA   1 
ATOM   5898 H HB   . THR   B 1 173 ? 10.77544  -3.97866  5.56261   1.000 21.81195 ? 651 THR   A HB   1 
ATOM   5899 H HG1  . THR   B 1 173 ? 10.41017  -5.96871  4.68791   1.000 21.19500 ? 651 THR   A HG1  1 
ATOM   5900 H HG21 . THR   B 1 173 ? 11.83089  -3.00277  3.75715   1.000 23.06992 ? 651 THR   A HG21 1 
ATOM   5901 H HG22 . THR   B 1 173 ? 12.86146  -2.96092  4.95243   1.000 23.06992 ? 651 THR   A HG22 1 
ATOM   5902 H HG23 . THR   B 1 173 ? 13.00890  -4.05193  3.82086   1.000 23.06992 ? 651 THR   A HG23 1 
ATOM   5903 N N    . ASN   B 1 174 ? 13.08413  -7.02348  4.88498   1.000 17.37453 ? 652 ASN   A N    1 
ATOM   5904 C CA   . ASN   B 1 174 ? 14.10599  -7.79457  4.16882   1.000 17.50507 ? 652 ASN   A CA   1 
ATOM   5905 C C    . ASN   B 1 174 ? 14.58750  -7.08650  2.91306   1.000 18.04710 ? 652 ASN   A C    1 
ATOM   5906 O O    . ASN   B 1 174 ? 15.73365  -7.31412  2.47687   1.000 18.90457 ? 652 ASN   A O    1 
ATOM   5907 C CB   . ASN   B 1 174 ? 13.54850  -9.18486  3.81153   1.000 15.73112 ? 652 ASN   A CB   1 
ATOM   5908 C CG   . ASN   B 1 174 ? 12.41861  -9.10592  2.83953   1.000 18.22152 ? 652 ASN   A CG   1 
ATOM   5909 O OD1  . ASN   B 1 174 ? 11.41022  -8.40386  3.06731   1.000 16.83897 ? 652 ASN   A OD1  1 
ATOM   5910 N ND2  . ASN   B 1 174 ? 12.57374  -9.80563  1.72113   1.000 20.84216 ? 652 ASN   A ND2  1 
ATOM   5911 H H    . ASN   B 1 174 ? 12.27532  -7.28982  4.76462   1.000 20.80345 ? 652 ASN   A H    1 
ATOM   5912 H HA   . ASN   B 1 174 ? 14.87354  -7.91367  4.74984   1.000 20.96009 ? 652 ASN   A HA   1 
ATOM   5913 H HB2  . ASN   B 1 174 ? 14.25396  -9.71781  3.41254   1.000 18.83136 ? 652 ASN   A HB2  1 
ATOM   5914 H HB3  . ASN   B 1 174 ? 13.22393  -9.61464  4.61827   1.000 18.83136 ? 652 ASN   A HB3  1 
ATOM   5915 H HD21 . ASN   B 1 174 ? 11.95711  -9.80051  1.12169   1.000 24.96460 ? 652 ASN   A HD21 1 
ATOM   5916 H HD22 . ASN   B 1 174 ? 13.29080  -10.26376 1.59650   1.000 24.96460 ? 652 ASN   A HD22 1 
ATOM   5917 N N    . ASN   B 1 175 ? 13.75508  -6.23041  2.33636   1.000 18.22872 ? 653 ASN   A N    1 
ATOM   5918 C CA   . ASN   B 1 175 ? 13.99584  -5.64607  1.01879   1.000 20.63048 ? 653 ASN   A CA   1 
ATOM   5919 C C    . ASN   B 1 175 ? 13.13416  -4.39571  0.91279   1.000 21.95348 ? 653 ASN   A C    1 
ATOM   5920 O O    . ASN   B 1 175 ? 11.90895  -4.49212  0.86537   1.000 20.68005 ? 653 ASN   A O    1 
ATOM   5921 C CB   . ASN   B 1 175 ? 13.65514  -6.66231  -0.08047  1.000 21.44815 ? 653 ASN   A CB   1 
ATOM   5922 C CG   . ASN   B 1 175 ? 14.01188  -6.16451  -1.46134  1.000 24.12046 ? 653 ASN   A CG   1 
ATOM   5923 O OD1  . ASN   B 1 175 ? 13.34408  -5.29109  -2.02244  1.000 23.79306 ? 653 ASN   A OD1  1 
ATOM   5924 N ND2  . ASN   B 1 175 ? 15.08045  -6.71022  -2.02061  1.000 25.47958 ? 653 ASN   A ND2  1 
ATOM   5925 H H    . ASN   B 1 175 ? 13.02119  -5.96185  2.69536   1.000 21.82848 ? 653 ASN   A H    1 
ATOM   5926 H HA   . ASN   B 1 175 ? 14.92650  -5.38877  0.92624   1.000 24.71059 ? 653 ASN   A HA   1 
ATOM   5927 H HB2  . ASN   B 1 175 ? 14.14938  -7.48119  0.08094   1.000 25.69179 ? 653 ASN   A HB2  1 
ATOM   5928 H HB3  . ASN   B 1 175 ? 12.70192  -6.84105  -0.06223  1.000 25.69179 ? 653 ASN   A HB3  1 
ATOM   5929 H HD21 . ASN   B 1 175 ? 15.32814  -6.46316  -2.80624  1.000 30.52951 ? 653 ASN   A HD21 1 
ATOM   5930 H HD22 . ASN   B 1 175 ? 15.52696  -7.31179  -1.59831  1.000 30.52951 ? 653 ASN   A HD22 1 
ATOM   5931 N N    . THR   B 1 176 ? 13.77199  -3.22762  0.87483   1.000 21.45265 ? 654 THR   A N    1 
ATOM   5932 C CA   . THR   B 1 176 ? 13.03722  -1.96442  0.90769   1.000 21.57707 ? 654 THR   A CA   1 
ATOM   5933 C C    . THR   B 1 176 ? 12.27723  -1.70466  -0.37878  1.000 25.15675 ? 654 THR   A C    1 
ATOM   5934 O O    . THR   B 1 176 ? 11.20690  -1.08850  -0.34455  1.000 24.97105 ? 654 THR   A O    1 
ATOM   5935 C CB   . THR   B 1 176 ? 13.97752  -0.79151  1.18673   1.000 26.37528 ? 654 THR   A CB   1 
ATOM   5936 O OG1  . THR   B 1 176 ? 14.96696  -0.70715  0.14188   1.000 28.99852 ? 654 THR   A OG1  1 
ATOM   5937 C CG2  . THR   B 1 176 ? 14.66076  -0.96716  2.52400   1.000 22.00054 ? 654 THR   A CG2  1 
ATOM   5938 H H    . THR   B 1 176 ? 14.62611  -3.13773  0.83014   1.000 25.69719 ? 654 THR   A H    1 
ATOM   5939 H HA   . THR   B 1 176 ? 12.39801  -2.02219  1.63500   1.000 25.84649 ? 654 THR   A HA   1 
ATOM   5940 H HB   . THR   B 1 176 ? 13.46988  0.03462   1.21317   1.000 31.60436 ? 654 THR   A HB   1 
ATOM   5941 H HG1  . THR   B 1 176 ? 15.41653  -1.41617  0.11400   1.000 34.75224 ? 654 THR   A HG1  1 
ATOM   5942 H HG21 . THR   B 1 176 ? 15.21889  -0.19717  2.71507   1.000 26.35467 ? 654 THR   A HG21 1 
ATOM   5943 H HG22 . THR   B 1 176 ? 13.99756  -1.05723  3.22610   1.000 26.35467 ? 654 THR   A HG22 1 
ATOM   5944 H HG23 . THR   B 1 176 ? 15.21559  -1.76271  2.51112   1.000 26.35467 ? 654 THR   A HG23 1 
ATOM   5945 N N    . ARG   B 1 177 ? 12.77799  -2.19450  -1.50572  1.000 25.72894 ? 655 ARG   A N    1 
ATOM   5946 C CA   . ARG   B 1 177 ? 12.11685  -1.94580  -2.78607  1.000 28.49300 ? 655 ARG   A CA   1 
ATOM   5947 C C    . ARG   B 1 177 ? 10.87684  -2.82037  -2.96263  1.000 27.88102 ? 655 ARG   A C    1 
ATOM   5948 O O    . ARG   B 1 177 ? 9.87226   -2.37329  -3.53280  1.000 27.94680 ? 655 ARG   A O    1 
ATOM   5949 C CB   . ARG   B 1 177 ? 13.11600  -2.17811  -3.92549  1.000 30.26725 ? 655 ARG   A CB   1 
ATOM   5950 C CG   . ARG   B 1 177 ? 12.53601  -2.09273  -5.33034  1.000 40.80816 ? 655 ARG   A CG   1 
ATOM   5951 C CD   . ARG   B 1 177 ? 13.64596  -2.23996  -6.36557  1.000 57.51597 ? 655 ARG   A CD   1 
ATOM   5952 N NE   . ARG   B 1 177 ? 13.14739  -2.62456  -7.68146  1.000 77.81669 ? 655 ARG   A NE   1 
ATOM   5953 C CZ   . ARG   B 1 177 ? 13.91923  -2.87478  -8.73437  1.000 78.78624 ? 655 ARG   A CZ   1 
ATOM   5954 N NH1  . ARG   B 1 177 ? 15.24135  -2.79107  -8.66278  1.000 67.84579 ? 655 ARG   A NH1  1 
ATOM   5955 N NH2  . ARG   B 1 177 ? 13.35147  -3.22103  -9.88861  1.000 77.95907 ? 655 ARG   A NH2  1 
ATOM   5956 H H    . ARG   B 1 177 ? 13.49252  -2.67001  -1.55973  1.000 30.82875 ? 655 ARG   A H    1 
ATOM   5957 H HA   . ARG   B 1 177 ? 11.82431  -1.02165  -2.82148  1.000 34.14562 ? 655 ARG   A HA   1 
ATOM   5958 H HB2  . ARG   B 1 177 ? 13.81483  -1.50859  -3.86009  1.000 36.27471 ? 655 ARG   A HB2  1 
ATOM   5959 H HB3  . ARG   B 1 177 ? 13.49547  -3.06488  -3.82282  1.000 36.27471 ? 655 ARG   A HB3  1 
ATOM   5960 H HG2  . ARG   B 1 177 ? 11.89201  -2.80611  -5.46171  1.000 48.92381 ? 655 ARG   A HG2  1 
ATOM   5961 H HG3  . ARG   B 1 177 ? 12.10723  -1.23161  -5.45488  1.000 48.92381 ? 655 ARG   A HG3  1 
ATOM   5962 H HD2  . ARG   B 1 177 ? 14.10731  -1.39157  -6.45668  1.000 68.97317 ? 655 ARG   A HD2  1 
ATOM   5963 H HD3  . ARG   B 1 177 ? 14.26583  -2.92447  -6.06872  1.000 68.97317 ? 655 ARG   A HD3  1 
ATOM   5964 H HE   . ARG   B 1 177 ? 12.29623  -2.69414  -7.78292  1.000 93.33404 ? 655 ARG   A HE   1 
ATOM   5965 H HH11 . ARG   B 1 177 ? 15.61877  -2.57041  -7.92219  1.000 81.36896 ? 655 ARG   A HH11 1 
ATOM   5966 H HH12 . ARG   B 1 177 ? 15.72096  -2.95746  -9.35696  1.000 81.36896 ? 655 ARG   A HH12 1 
ATOM   5967 H HH21 . ARG   B 1 177 ? 12.49544  -3.28036  -9.94600  1.000 93.50490 ? 655 ARG   A HH21 1 
ATOM   5968 H HH22 . ARG   B 1 177 ? 13.84096  -3.38523  -10.57639 1.000 93.50490 ? 655 ARG   A HH22 1 
ATOM   5969 N N    . SER   B 1 178 ? 10.91439  -4.04857  -2.45685  1.000 22.74916 ? 656 SER   A N    1 
ATOM   5970 C CA   . SER   B 1 178 ? 9.82401   -5.00315  -2.61463  1.000 23.89087 ? 656 SER   A CA   1 
ATOM   5971 C C    . SER   B 1 178 ? 9.75043   -5.81776  -1.32915  1.000 23.13732 ? 656 SER   A C    1 
ATOM   5972 O O    . SER   B 1 178 ? 10.16968  -6.97830  -1.27291  1.000 21.86822 ? 656 SER   A O    1 
ATOM   5973 C CB   . SER   B 1 178 ? 10.04837  -5.89147  -3.84294  1.000 26.14843 ? 656 SER   A CB   1 
ATOM   5974 O OG   . SER   B 1 178 ? 8.95201   -6.76275  -4.03188  1.000 34.85436 ? 656 SER   A OG   1 
ATOM   5975 H H    . SER   B 1 178 ? 11.57804  -4.35956  -2.00691  1.000 27.25301 ? 656 SER   A H    1 
ATOM   5976 H HA   . SER   B 1 178 ? 8.98007   -4.54190  -2.74074  1.000 28.62306 ? 656 SER   A HA   1 
ATOM   5977 H HB2  . SER   B 1 178 ? 10.14513  -5.32911  -4.62735  1.000 31.33213 ? 656 SER   A HB2  1 
ATOM   5978 H HB3  . SER   B 1 178 ? 10.85237  -6.41780  -3.71083  1.000 31.33213 ? 656 SER   A HB3  1 
ATOM   5979 H HG   . SER   B 1 178 ? 9.08226   -7.24638  -4.70622  1.000 41.77925 ? 656 SER   A HG   1 
ATOM   5980 N N    . PRO   B 1 179 ? 9.22909   -5.23306  -0.26437  1.000 20.05931 ? 657 PRO   A N    1 
ATOM   5981 C CA   . PRO   B 1 179 ? 9.22703   -5.93232  1.02261   1.000 18.42436 ? 657 PRO   A CA   1 
ATOM   5982 C C    . PRO   B 1 179 ? 8.27921   -7.12718  1.05164   1.000 19.94707 ? 657 PRO   A C    1 
ATOM   5983 O O    . PRO   B 1 179 ? 7.18865   -7.11299  0.47934   1.000 19.95658 ? 657 PRO   A O    1 
ATOM   5984 C CB   . PRO   B 1 179 ? 8.78840   -4.84116  2.01647   1.000 21.60005 ? 657 PRO   A CB   1 
ATOM   5985 C CG   . PRO   B 1 179 ? 8.04471   -3.86154  1.19510   1.000 22.58636 ? 657 PRO   A CG   1 
ATOM   5986 C CD   . PRO   B 1 179 ? 8.66975   -3.87131  -0.16674  1.000 23.50524 ? 657 PRO   A CD   1 
ATOM   5987 H HA   . PRO   B 1 179 ? 10.12230  -6.24166  1.23162   1.000 22.06325 ? 657 PRO   A HA   1 
ATOM   5988 H HB2  . PRO   B 1 179 ? 8.21839   -5.22592  2.70054   1.000 25.87407 ? 657 PRO   A HB2  1 
ATOM   5989 H HB3  . PRO   B 1 179 ? 9.56756   -4.43266  2.42506   1.000 25.87407 ? 657 PRO   A HB3  1 
ATOM   5990 H HG2  . PRO   B 1 179 ? 7.11272   -4.12530  1.14301   1.000 27.05765 ? 657 PRO   A HG2  1 
ATOM   5991 H HG3  . PRO   B 1 179 ? 8.11853   -2.98155  1.59643   1.000 27.05765 ? 657 PRO   A HG3  1 
ATOM   5992 H HD2  . PRO   B 1 179 ? 8.00313   -3.72036  -0.85503  1.000 28.16030 ? 657 PRO   A HD2  1 
ATOM   5993 H HD3  . PRO   B 1 179 ? 9.37031   -3.20351  -0.23125  1.000 28.16030 ? 657 PRO   A HD3  1 
ATOM   5994 N N    . LYS   B 1 180 ? 8.71661   -8.16926  1.72257   1.000 16.33818 ? 658 LYS   A N    1 
ATOM   5995 C CA   . LYS   B 1 180 ? 7.86006   -9.30878  2.00347   1.000 18.27417 ? 658 LYS   A CA   1 
ATOM   5996 C C    . LYS   B 1 180 ? 7.66994   -9.58504  3.48743   1.000 17.28049 ? 658 LYS   A C    1 
ATOM   5997 O O    . LYS   B 1 180 ? 6.77664   -10.36445 3.84624   1.000 15.04467 ? 658 LYS   A O    1 
ATOM   5998 C CB   . LYS   B 1 180 ? 8.41523   -10.58268 1.31515   1.000 20.42539 ? 658 LYS   A CB   1 
ATOM   5999 C CG   . LYS   B 1 180 ? 8.20903   -10.55598 -0.20553  1.000 24.31555 ? 658 LYS   A CG   1 
ATOM   6000 C CD   . LYS   B 1 180 ? 6.70186   -10.52660 -0.57137  1.000 23.09393 ? 658 LYS   A CD   1 
ATOM   6001 C CE   . LYS   B 1 180 ? 6.50370   -10.72222 -2.07754  1.000 29.18014 ? 658 LYS   A CE   1 
ATOM   6002 N NZ   . LYS   B 1 180 ? 5.07086   -10.73030 -2.44025  1.000 29.61390 ? 658 LYS   A NZ   1 
ATOM   6003 H H    . LYS   B 1 180 ? 9.51543   -8.24569  2.03183   1.000 19.55983 ? 658 LYS   A H    1 
ATOM   6004 H HA   . LYS   B 1 180 ? 6.98255   -9.13274  1.62946   1.000 21.88302 ? 658 LYS   A HA   1 
ATOM   6005 H HB2  . LYS   B 1 180 ? 9.36687   -10.64976 1.49061   1.000 24.46449 ? 658 LYS   A HB2  1 
ATOM   6006 H HB3  . LYS   B 1 180 ? 7.95692   -11.36077 1.66931   1.000 24.46449 ? 658 LYS   A HB3  1 
ATOM   6007 H HG2  . LYS   B 1 180 ? 8.62803   -9.76214  -0.57317  1.000 29.13267 ? 658 LYS   A HG2  1 
ATOM   6008 H HG3  . LYS   B 1 180 ? 8.60300   -11.35091 -0.59767  1.000 29.13267 ? 658 LYS   A HG3  1 
ATOM   6009 H HD2  . LYS   B 1 180 ? 6.24128   -11.24159 -0.10492  1.000 27.66673 ? 658 LYS   A HD2  1 
ATOM   6010 H HD3  . LYS   B 1 180 ? 6.32415   -9.66924  -0.32003  1.000 27.66673 ? 658 LYS   A HD3  1 
ATOM   6011 H HE2  . LYS   B 1 180 ? 6.93486   -9.99619  -2.55491  1.000 34.97018 ? 658 LYS   A HE2  1 
ATOM   6012 H HE3  . LYS   B 1 180 ? 6.89050   -11.57074 -2.34457  1.000 34.97018 ? 658 LYS   A HE3  1 
ATOM   6013 H HZ1  . LYS   B 1 180 ? 4.65377   -11.39367 -2.01825  1.000 35.49070 ? 658 LYS   A HZ1  1 
ATOM   6014 H HZ2  . LYS   B 1 180 ? 4.69380   -9.95819  -2.20835  1.000 35.49070 ? 658 LYS   A HZ2  1 
ATOM   6015 H HZ3  . LYS   B 1 180 ? 4.97975   -10.84403 -3.31824  1.000 35.49070 ? 658 LYS   A HZ3  1 
ATOM   6016 N N    . LEU   B 1 181 ? 8.50882   -9.01758  4.35430   1.000 17.39616 ? 659 LEU   A N    1 
ATOM   6017 C CA   . LEU   B 1 181 ? 8.32772   -9.13155  5.78564   1.000 14.73042 ? 659 LEU   A CA   1 
ATOM   6018 C C    . LEU   B 1 181 ? 8.73045   -7.80865  6.43289   1.000 17.87700 ? 659 LEU   A C    1 
ATOM   6019 O O    . LEU   B 1 181 ? 9.55137   -7.05977  5.89492   1.000 16.66053 ? 659 LEU   A O    1 
ATOM   6020 C CB   . LEU   B 1 181 ? 9.11377   -10.27486 6.38143   1.000 17.97795 ? 659 LEU   A CB   1 
ATOM   6021 C CG   . LEU   B 1 181 ? 10.61001  -10.27342 6.25484   1.000 19.39402 ? 659 LEU   A CG   1 
ATOM   6022 C CD1  . LEU   B 1 181 ? 11.23515  -9.46948  7.41412   1.000 19.37059 ? 659 LEU   A CD1  1 
ATOM   6023 C CD2  . LEU   B 1 181 ? 11.14265  -11.69736 6.24350   1.000 23.29184 ? 659 LEU   A CD2  1 
ATOM   6024 H H    . LEU   B 1 181 ? 9.19805   -8.55630  4.12674   1.000 20.82940 ? 659 LEU   A H    1 
ATOM   6025 H HA   . LEU   B 1 181 ? 7.39314   -9.30130  5.98219   1.000 17.63051 ? 659 LEU   A HA   1 
ATOM   6026 H HB2  . LEU   B 1 181 ? 8.91901   -10.29743 7.33141   1.000 21.52755 ? 659 LEU   A HB2  1 
ATOM   6027 H HB3  . LEU   B 1 181 ? 8.80372   -11.09151 5.95971   1.000 21.52755 ? 659 LEU   A HB3  1 
ATOM   6028 H HG   . LEU   B 1 181 ? 10.86344  -9.85303  5.41821   1.000 23.22683 ? 659 LEU   A HG   1 
ATOM   6029 H HD11 . LEU   B 1 181 ? 12.17873  -9.68573  7.47561   1.000 23.19873 ? 659 LEU   A HD11 1 
ATOM   6030 H HD12 . LEU   B 1 181 ? 11.12371  -8.52220  7.23764   1.000 23.19873 ? 659 LEU   A HD12 1 
ATOM   6031 H HD13 . LEU   B 1 181 ? 10.78682  -9.70690  8.24088   1.000 23.19873 ? 659 LEU   A HD13 1 
ATOM   6032 H HD21 . LEU   B 1 181 ? 12.11059  -11.67201 6.18549   1.000 27.90422 ? 659 LEU   A HD21 1 
ATOM   6033 H HD22 . LEU   B 1 181 ? 10.87186  -12.14235 7.06176   1.000 27.90422 ? 659 LEU   A HD22 1 
ATOM   6034 H HD23 . LEU   B 1 181 ? 10.77743  -12.16505 5.47618   1.000 27.90422 ? 659 LEU   A HD23 1 
ATOM   6035 N N    . PHE   B 1 182 ? 8.10145   -7.51190  7.56106   1.000 15.42363 ? 660 PHE   A N    1 
ATOM   6036 C CA   . PHE   B 1 182 ? 8.42246   -6.36218  8.38206   1.000 16.45687 ? 660 PHE   A CA   1 
ATOM   6037 C C    . PHE   B 1 182 ? 8.66102   -6.81840  9.81377   1.000 17.14722 ? 660 PHE   A C    1 
ATOM   6038 O O    . PHE   B 1 182 ? 8.04793   -7.76756  10.30292  1.000 15.83709 ? 660 PHE   A O    1 
ATOM   6039 C CB   . PHE   B 1 182 ? 7.29442   -5.30412  8.34193   1.000 16.81725 ? 660 PHE   A CB   1 
ATOM   6040 C CG   . PHE   B 1 182 ? 7.15647   -4.61554  7.00528   1.000 14.50899 ? 660 PHE   A CG   1 
ATOM   6041 C CD1  . PHE   B 1 182 ? 6.33677   -5.11860  6.03269   1.000 15.14134 ? 660 PHE   A CD1  1 
ATOM   6042 C CD2  . PHE   B 1 182 ? 7.83986   -3.44765  6.73374   1.000 15.00629 ? 660 PHE   A CD2  1 
ATOM   6043 C CE1  . PHE   B 1 182 ? 6.19300   -4.49803  4.82179   1.000 17.87400 ? 660 PHE   A CE1  1 
ATOM   6044 C CE2  . PHE   B 1 182 ? 7.69086   -2.81802  5.53114   1.000 16.23931 ? 660 PHE   A CE2  1 
ATOM   6045 C CZ   . PHE   B 1 182 ? 6.87944   -3.34826  4.55763   1.000 16.79055 ? 660 PHE   A CZ   1 
ATOM   6046 H H    . PHE   B 1 182 ? 7.45823   -7.98342  7.88282   1.000 18.46237 ? 660 PHE   A H    1 
ATOM   6047 H HA   . PHE   B 1 182 ? 9.23504   -5.94318  8.05794   1.000 19.70225 ? 660 PHE   A HA   1 
ATOM   6048 H HB2  . PHE   B 1 182 ? 6.45056   -5.73977  8.53944   1.000 20.13471 ? 660 PHE   A HB2  1 
ATOM   6049 H HB3  . PHE   B 1 182 ? 7.48051   -4.62393  9.00797   1.000 20.13471 ? 660 PHE   A HB3  1 
ATOM   6050 H HD1  . PHE   B 1 182 ? 5.86500   -5.90267  6.19875   1.000 18.12363 ? 660 PHE   A HD1  1 
ATOM   6051 H HD2  . PHE   B 1 182 ? 8.40720   -3.08603  7.37582   1.000 17.96156 ? 660 PHE   A HD2  1 
ATOM   6052 H HE1  . PHE   B 1 182 ? 5.62727   -4.85983  4.17840   1.000 21.40282 ? 660 PHE   A HE1  1 
ATOM   6053 H HE2  . PHE   B 1 182 ? 8.14348   -2.02185  5.36946   1.000 19.44119 ? 660 PHE   A HE2  1 
ATOM   6054 H HZ   . PHE   B 1 182 ? 6.79906   -2.93001  3.73088   1.000 20.10268 ? 660 PHE   A HZ   1 
ATOM   6055 N N    . VAL   B 1 183 ? 9.59897   -6.15792  10.47514  1.000 15.01176 ? 661 VAL   A N    1 
ATOM   6056 C CA   . VAL   B 1 183 ? 9.90754   -6.41755  11.87106  1.000 15.64755 ? 661 VAL   A CA   1 
ATOM   6057 C C    . VAL   B 1 183 ? 9.67630   -5.12928  12.65459  1.000 15.43732 ? 661 VAL   A C    1 
ATOM   6058 O O    . VAL   B 1 183 ? 10.15397  -4.06852  12.25621  1.000 14.60260 ? 661 VAL   A O    1 
ATOM   6059 C CB   . VAL   B 1 183 ? 11.35748  -6.91028  12.04645  1.000 17.43219 ? 661 VAL   A CB   1 
ATOM   6060 C CG1  . VAL   B 1 183 ? 11.62600  -7.32112  13.50412  1.000 16.60148 ? 661 VAL   A CG1  1 
ATOM   6061 C CG2  . VAL   B 1 183 ? 11.63862  -8.08931  11.11289  1.000 17.71691 ? 661 VAL   A CG2  1 
ATOM   6062 H H    . VAL   B 1 183 ? 10.08262  -5.53818  10.12641  1.000 17.96813 ? 661 VAL   A H    1 
ATOM   6063 H HA   . VAL   B 1 183 ? 9.30854   -7.09886  12.21446  1.000 18.73107 ? 661 VAL   A HA   1 
ATOM   6064 H HB   . VAL   B 1 183 ? 11.95652  -6.18186  11.81960  1.000 20.87265 ? 661 VAL   A HB   1 
ATOM   6065 H HG11 . VAL   B 1 183 ? 12.51639  -7.70090  13.56628  1.000 19.87579 ? 661 VAL   A HG11 1 
ATOM   6066 H HG12 . VAL   B 1 183 ? 11.56083  -6.53637  14.07053  1.000 19.87579 ? 661 VAL   A HG12 1 
ATOM   6067 H HG13 . VAL   B 1 183 ? 10.96618  -7.97915  13.77342  1.000 19.87579 ? 661 VAL   A HG13 1 
ATOM   6068 H HG21 . VAL   B 1 183 ? 12.51795  -8.44711  11.31204  1.000 21.21431 ? 661 VAL   A HG21 1 
ATOM   6069 H HG22 . VAL   B 1 183 ? 10.96401  -8.77183  11.25419  1.000 21.21431 ? 661 VAL   A HG22 1 
ATOM   6070 H HG23 . VAL   B 1 183 ? 11.60799  -7.77909  10.19435  1.000 21.21431 ? 661 VAL   A HG23 1 
ATOM   6071 N N    . VAL   B 1 184 ? 8.90504   -5.21244  13.73638  1.000 16.88127 ? 662 VAL   A N    1 
ATOM   6072 C CA   . VAL   B 1 184 ? 8.72122   -4.09025  14.64720  1.000 15.17454 ? 662 VAL   A CA   1 
ATOM   6073 C C    . VAL   B 1 184 ? 9.24860   -4.48683  16.01843  1.000 15.00418 ? 662 VAL   A C    1 
ATOM   6074 O O    . VAL   B 1 184 ? 9.21452   -5.65353  16.41715  1.000 14.94534 ? 662 VAL   A O    1 
ATOM   6075 C CB   . VAL   B 1 184 ? 7.25859   -3.60757  14.76796  1.000 18.77773 ? 662 VAL   A CB   1 
ATOM   6076 C CG1  . VAL   B 1 184 ? 6.77497   -3.09873  13.42065  1.000 19.67166 ? 662 VAL   A CG1  1 
ATOM   6077 C CG2  . VAL   B 1 184 ? 6.39849   -4.71462  15.27962  1.000 19.07543 ? 662 VAL   A CG2  1 
ATOM   6078 H H    . VAL   B 1 184 ? 8.47252   -5.91961  13.96537  1.000 20.21154 ? 662 VAL   A H    1 
ATOM   6079 H HA   . VAL   B 1 184 ? 9.23914   -3.34797  14.29837  1.000 18.16347 ? 662 VAL   A HA   1 
ATOM   6080 H HB   . VAL   B 1 184 ? 7.19914   -2.87464  15.40056  1.000 22.48729 ? 662 VAL   A HB   1 
ATOM   6081 H HG11 . VAL   B 1 184 ? 5.86205   -2.78368  13.51124  1.000 23.56001 ? 662 VAL   A HG11 1 
ATOM   6082 H HG12 . VAL   B 1 184 ? 7.34888   -2.37148  13.13321  1.000 23.56001 ? 662 VAL   A HG12 1 
ATOM   6083 H HG13 . VAL   B 1 184 ? 6.81240   -3.82372  12.77731  1.000 23.56001 ? 662 VAL   A HG13 1 
ATOM   6084 H HG21 . VAL   B 1 184 ? 5.46846   -4.44582  15.21894  1.000 22.84453 ? 662 VAL   A HG21 1 
ATOM   6085 H HG22 . VAL   B 1 184 ? 6.54967   -5.50686  14.74072  1.000 22.84453 ? 662 VAL   A HG22 1 
ATOM   6086 H HG23 . VAL   B 1 184 ? 6.63133   -4.89399  16.20402  1.000 22.84453 ? 662 VAL   A HG23 1 
ATOM   6087 N N    . PHE   B 1 185 ? 9.77727   -3.49198  16.73778  1.000 13.83213 ? 663 PHE   A N    1 
ATOM   6088 C CA   . PHE   B 1 185 ? 10.60115  -3.72067  17.90626  1.000 15.14908 ? 663 PHE   A CA   1 
ATOM   6089 C C    . PHE   B 1 185 ? 9.99639   -3.15842  19.18620  1.000 16.20688 ? 663 PHE   A C    1 
ATOM   6090 O O    . PHE   B 1 185 ? 10.65837  -3.18331  20.23428  1.000 18.36823 ? 663 PHE   A O    1 
ATOM   6091 C CB   . PHE   B 1 185 ? 11.99459  -3.09585  17.71086  1.000 15.85046 ? 663 PHE   A CB   1 
ATOM   6092 C CG   . PHE   B 1 185 ? 12.76099  -3.64357  16.55220  1.000 15.58836 ? 663 PHE   A CG   1 
ATOM   6093 C CD1  . PHE   B 1 185 ? 12.53956  -3.18367  15.28964  1.000 15.71614 ? 663 PHE   A CD1  1 
ATOM   6094 C CD2  . PHE   B 1 185 ? 13.74188  -4.62100  16.74586  1.000 16.81059 ? 663 PHE   A CD2  1 
ATOM   6095 C CE1  . PHE   B 1 185 ? 13.23255  -3.70065  14.19458  1.000 16.55125 ? 663 PHE   A CE1  1 
ATOM   6096 C CE2  . PHE   B 1 185 ? 14.45097  -5.12699  15.67051  1.000 18.78595 ? 663 PHE   A CE2  1 
ATOM   6097 C CZ   . PHE   B 1 185 ? 14.20464  -4.64556  14.38620  1.000 17.17997 ? 663 PHE   A CZ   1 
ATOM   6098 H H    . PHE   B 1 185 ? 9.66483   -2.65877  16.55691  1.000 16.55257 ? 663 PHE   A H    1 
ATOM   6099 H HA   . PHE   B 1 185 ? 10.69460  -4.68041  18.01144  1.000 18.13291 ? 663 PHE   A HA   1 
ATOM   6100 H HB2  . PHE   B 1 185 ? 11.88851  -2.14237  17.56762  1.000 18.97457 ? 663 PHE   A HB2  1 
ATOM   6101 H HB3  . PHE   B 1 185 ? 12.51958  -3.25476  18.51088  1.000 18.97457 ? 663 PHE   A HB3  1 
ATOM   6102 H HD1  . PHE   B 1 185 ? 11.91264  -2.51019  15.15438  1.000 18.81338 ? 663 PHE   A HD1  1 
ATOM   6103 H HD2  . PHE   B 1 185 ? 13.91911  -4.93342  17.60369  1.000 20.12672 ? 663 PHE   A HD2  1 
ATOM   6104 H HE1  . PHE   B 1 185 ? 13.03445  -3.40385  13.33577  1.000 19.81552 ? 663 PHE   A HE1  1 
ATOM   6105 H HE2  . PHE   B 1 185 ? 15.09140  -5.78782  15.80488  1.000 22.49716 ? 663 PHE   A HE2  1 
ATOM   6106 H HZ   . PHE   B 1 185 ? 14.69708  -4.96386  13.66433  1.000 20.56998 ? 663 PHE   A HZ   1 
ATOM   6107 N N    . PHE   B 1 186 ? 8.77148   -2.68149  19.13987  1.000 15.82442 ? 664 PHE   A N    1 
ATOM   6108 C CA   . PHE   B 1 186 ? 8.12318   -2.11634  20.31042  1.000 18.41896 ? 664 PHE   A CA   1 
ATOM   6109 C C    . PHE   B 1 186 ? 6.70739   -2.64005  20.47371  1.000 18.76280 ? 664 PHE   A C    1 
ATOM   6110 O O    . PHE   B 1 186 ? 6.02573   -2.97394  19.49796  1.000 19.50169 ? 664 PHE   A O    1 
ATOM   6111 C CB   . PHE   B 1 186 ? 8.12072   -0.60470  20.21401  1.000 17.30589 ? 664 PHE   A CB   1 
ATOM   6112 C CG   . PHE   B 1 186 ? 9.50850   -0.02407  20.18798  1.000 18.36518 ? 664 PHE   A CG   1 
ATOM   6113 C CD1  . PHE   B 1 186 ? 10.26999  0.04583   21.34791  1.000 22.95457 ? 664 PHE   A CD1  1 
ATOM   6114 C CD2  . PHE   B 1 186 ? 10.08161  0.39075   19.01050  1.000 18.17182 ? 664 PHE   A CD2  1 
ATOM   6115 C CE1  . PHE   B 1 186 ? 11.57075  0.55101   21.30501  1.000 22.42971 ? 664 PHE   A CE1  1 
ATOM   6116 C CE2  . PHE   B 1 186 ? 11.38856  0.87727   18.97138  1.000 21.01926 ? 664 PHE   A CE2  1 
ATOM   6117 C CZ   . PHE   B 1 186 ? 12.11452  0.94341   20.12254  1.000 22.04265 ? 664 PHE   A CZ   1 
ATOM   6118 H H    . PHE   B 1 186 ? 8.28383   -2.67213  18.43156  1.000 18.94331 ? 664 PHE   A H    1 
ATOM   6119 H HA   . PHE   B 1 186 ? 8.59825   -2.39191  21.10996  1.000 22.05677 ? 664 PHE   A HA   1 
ATOM   6120 H HB2  . PHE   B 1 186 ? 7.66875   -0.34064  19.39737  1.000 20.72109 ? 664 PHE   A HB2  1 
ATOM   6121 H HB3  . PHE   B 1 186 ? 7.65618   -0.23951  20.98326  1.000 20.72109 ? 664 PHE   A HB3  1 
ATOM   6122 H HD1  . PHE   B 1 186 ? 9.91206   -0.24485  22.15555  1.000 27.49950 ? 664 PHE   A HD1  1 
ATOM   6123 H HD2  . PHE   B 1 186 ? 9.58832   0.34636   18.22335  1.000 21.76020 ? 664 PHE   A HD2  1 
ATOM   6124 H HE1  . PHE   B 1 186 ? 12.06718  0.61934   22.08846  1.000 26.86966 ? 664 PHE   A HE1  1 
ATOM   6125 H HE2  . PHE   B 1 186 ? 11.76146  1.15433   18.16573  1.000 25.17713 ? 664 PHE   A HE2  1 
ATOM   6126 H HZ   . PHE   B 1 186 ? 12.98885  1.25949   20.09910  1.000 26.40519 ? 664 PHE   A HZ   1 
ATOM   6127 N N    . ASP   B 1 187 ? 6.29310   -2.74098  21.72972  1.000 18.07102 ? 665 ASP   A N    1 
ATOM   6128 C CA   . ASP   B 1 187 ? 4.94564   -3.15196  22.01950  1.000 18.26950 ? 665 ASP   A CA   1 
ATOM   6129 C C    . ASP   B 1 187 ? 3.96541   -2.12822  21.42955  1.000 22.14210 ? 665 ASP   A C    1 
ATOM   6130 O O    . ASP   B 1 187 ? 4.25832   -0.93259  21.32890  1.000 24.81708 ? 665 ASP   A O    1 
ATOM   6131 C CB   . ASP   B 1 187 ? 4.70855   -3.23472  23.52884  1.000 18.89495 ? 665 ASP   A CB   1 
ATOM   6132 C CG   . ASP   B 1 187 ? 5.68199   -4.17035  24.23556  1.000 20.35303 ? 665 ASP   A CG   1 
ATOM   6133 O OD1  . ASP   B 1 187 ? 6.19147   -5.08734  23.56950  1.000 15.53865 ? 665 ASP   A OD1  1 
ATOM   6134 O OD2  . ASP   B 1 187 ? 5.95662   -3.95632  25.44961  1.000 21.56125 ? 665 ASP   A OD2  1 
ATOM   6135 H H    . ASP   B 1 187 ? 6.77573   -2.57642  22.42224  1.000 21.63924 ? 665 ASP   A H    1 
ATOM   6136 H HA   . ASP   B 1 187 ? 4.79040   -4.02982  21.63719  1.000 21.87742 ? 665 ASP   A HA   1 
ATOM   6137 H HB2  . ASP   B 1 187 ? 4.81242   -2.35008  23.91293  1.000 22.62795 ? 665 ASP   A HB2  1 
ATOM   6138 H HB3  . ASP   B 1 187 ? 3.80975   -3.56247  23.68895  1.000 22.62795 ? 665 ASP   A HB3  1 
ATOM   6139 N N    . ASN   B 1 188 ? 2.79347   -2.60157  21.07184  1.000 24.34188 ? 666 ASN   A N    1 
ATOM   6140 C CA   . ASN   B 1 188 ? 1.72443   -1.67915  20.65278  1.000 27.21321 ? 666 ASN   A CA   1 
ATOM   6141 C C    . ASN   B 1 188 ? 2.07434   -0.93037  19.35300  1.000 21.91291 ? 666 ASN   A C    1 
ATOM   6142 O O    . ASN   B 1 188 ? 1.46106   0.09578   19.00103  1.000 19.12075 ? 666 ASN   A O    1 
ATOM   6143 C CB   . ASN   B 1 188 ? 1.38486   -0.70380  21.78050  1.000 30.92611 ? 666 ASN   A CB   1 
ATOM   6144 C CG   . ASN   B 1 188 ? 1.10173   -1.42361  23.12477  1.000 29.28188 ? 666 ASN   A CG   1 
ATOM   6145 O OD1  . ASN   B 1 188 ? 1.69368   -1.10724  24.16381  1.000 31.18117 ? 666 ASN   A OD1  1 
ATOM   6146 N ND2  . ASN   B 1 188 ? 0.20946   -2.40752  23.09542  1.000 24.50788 ? 666 ASN   A ND2  1 
ATOM   6147 H H    . ASN   B 1 188 ? 2.58326   -3.43538  21.05899  1.000 29.16427 ? 666 ASN   A H    1 
ATOM   6148 H HA   . ASN   B 1 188 ? 0.92505   -2.19372  20.46013  1.000 32.60987 ? 666 ASN   A HA   1 
ATOM   6149 H HB2  . ASN   B 1 188 ? 2.13291   -0.10088  21.91392  1.000 37.06535 ? 666 ASN   A HB2  1 
ATOM   6150 H HB3  . ASN   B 1 188 ? 0.59252   -0.20042  21.53618  1.000 37.06535 ? 666 ASN   A HB3  1 
ATOM   6151 H HD21 . ASN   B 1 188 ? 0.01874   -2.83667  23.81588  1.000 29.36347 ? 666 ASN   A HD21 1 
ATOM   6152 H HD22 . ASN   B 1 188 ? -0.17739  -2.61527  22.35598  1.000 29.36347 ? 666 ASN   A HD22 1 
ATOM   6153 N N    . GLN   B 1 189 ? 3.04324   -1.45149  18.58348  1.000 17.96120 ? 667 GLN   A N    1 
ATOM   6154 C CA   . GLN   B 1 189 ? 3.16039   -1.07224  17.19509  1.000 16.09870 ? 667 GLN   A CA   1 
ATOM   6155 C C    . GLN   B 1 189 ? 2.37533   -1.99291  16.26644  1.000 16.07475 ? 667 GLN   A C    1 
ATOM   6156 O O    . GLN   B 1 189 ? 2.46897   -1.84170  15.05406  1.000 15.70211 ? 667 GLN   A O    1 
ATOM   6157 C CB   . GLN   B 1 189 ? 4.63511   -1.06918  16.78419  1.000 19.88998 ? 667 GLN   A CB   1 
ATOM   6158 C CG   . GLN   B 1 189 ? 5.07872   0.21894   16.23879  1.000 19.61492 ? 667 GLN   A CG   1 
ATOM   6159 C CD   . GLN   B 1 189 ? 6.56216   0.21405   15.84826  1.000 17.41192 ? 667 GLN   A CD   1 
ATOM   6160 O OE1  . GLN   B 1 189 ? 7.41730   -0.03915  16.66862  1.000 18.52043 ? 667 GLN   A OE1  1 
ATOM   6161 N NE2  . GLN   B 1 189 ? 6.83143   0.49698   14.57165  1.000 15.23365 ? 667 GLN   A NE2  1 
ATOM   6162 H H    . GLN   B 1 189 ? 3.63068   -2.01878  18.85308  1.000 21.50746 ? 667 GLN   A H    1 
ATOM   6163 H HA   . GLN   B 1 189 ? 2.81424   -0.17295  17.08397  1.000 19.27245 ? 667 GLN   A HA   1 
ATOM   6164 H HB2  . GLN   B 1 189 ? 5.17868   -1.26715  17.56280  1.000 23.82199 ? 667 GLN   A HB2  1 
ATOM   6165 H HB3  . GLN   B 1 189 ? 4.77285   -1.74560  16.10273  1.000 23.82199 ? 667 GLN   A HB3  1 
ATOM   6166 H HG2  . GLN   B 1 189 ? 4.55956   0.42252   15.44510  1.000 23.49191 ? 667 GLN   A HG2  1 
ATOM   6167 H HG3  . GLN   B 1 189 ? 4.94623   0.90868   16.90782  1.000 23.49191 ? 667 GLN   A HG3  1 
ATOM   6168 H HE21 . GLN   B 1 189 ? 6.19021   0.66761   14.02454  1.000 18.23439 ? 667 GLN   A HE21 1 
ATOM   6169 H HE22 . GLN   B 1 189 ? 7.64610   0.50861   14.29638  1.000 18.23439 ? 667 GLN   A HE22 1 
ATOM   6170 N N    . ALA   B 1 190 ? 1.59813   -2.93839  16.81543  1.000 15.03954 ? 668 ALA   A N    1 
ATOM   6171 C CA   . ALA   B 1 190 ? 0.86256   -3.89489  16.00750  1.000 16.43589 ? 668 ALA   A CA   1 
ATOM   6172 C C    . ALA   B 1 190 ? -0.41215  -4.21139  16.76664  1.000 18.27067 ? 668 ALA   A C    1 
ATOM   6173 O O    . ALA   B 1 190 ? -0.35228  -4.51095  17.96486  1.000 20.73837 ? 668 ALA   A O    1 
ATOM   6174 C CB   . ALA   B 1 190 ? 1.65653   -5.16421  15.77279  1.000 17.11253 ? 668 ALA   A CB   1 
ATOM   6175 H H    . ALA   B 1 190 ? 1.48572   -3.03948  17.66204  1.000 18.00146 ? 668 ALA   A H    1 
ATOM   6176 H HA   . ALA   B 1 190 ? 0.65537   -3.51787  15.13812  1.000 19.67708 ? 668 ALA   A HA   1 
ATOM   6177 H HB1  . ALA   B 1 190 ? 1.12813   -5.77175  15.23187  1.000 20.48906 ? 668 ALA   A HB1  1 
ATOM   6178 H HB2  . ALA   B 1 190 ? 2.47978   -4.94091  15.31095  1.000 20.48906 ? 668 ALA   A HB2  1 
ATOM   6179 H HB3  . ALA   B 1 190 ? 1.85804   -5.57350  16.62881  1.000 20.48906 ? 668 ALA   A HB3  1 
ATOM   6180 N N    . TYR   B 1 191 ? -1.54466  -4.20970  16.06773  1.000 15.53397 ? 669 TYR   A N    1 
ATOM   6181 C CA   . TYR   B 1 191 ? -2.82025  -4.56417  16.69491  1.000 14.13299 ? 669 TYR   A CA   1 
ATOM   6182 C C    . TYR   B 1 191 ? -3.35295  -5.80866  16.00545  1.000 14.99154 ? 669 TYR   A C    1 
ATOM   6183 O O    . TYR   B 1 191 ? -3.61992  -5.75166  14.78941  1.000 15.83880 ? 669 TYR   A O    1 
ATOM   6184 C CB   . TYR   B 1 191 ? -3.84402  -3.44832  16.58144  1.000 16.56653 ? 669 TYR   A CB   1 
ATOM   6185 C CG   . TYR   B 1 191 ? -5.14449  -3.84456  17.19622  1.000 16.15452 ? 669 TYR   A CG   1 
ATOM   6186 C CD1  . TYR   B 1 191 ? -5.33679  -3.76550  18.58977  1.000 15.41940 ? 669 TYR   A CD1  1 
ATOM   6187 C CD2  . TYR   B 1 191 ? -6.19186  -4.33620  16.41638  1.000 16.42566 ? 669 TYR   A CD2  1 
ATOM   6188 C CE1  . TYR   B 1 191 ? -6.52903  -4.14544  19.15700  1.000 15.46720 ? 669 TYR   A CE1  1 
ATOM   6189 C CE2  . TYR   B 1 191 ? -7.37975  -4.71772  17.00131  1.000 15.88467 ? 669 TYR   A CE2  1 
ATOM   6190 C CZ   . TYR   B 1 191 ? -7.52852  -4.64957  18.36641  1.000 17.00507 ? 669 TYR   A CZ   1 
ATOM   6191 O OH   . TYR   B 1 191 ? -8.70187  -5.08038  18.94221  1.000 16.30182 ? 669 TYR   A OH   1 
ATOM   6192 H H    . TYR   B 1 191 ? -1.60136  -4.00827  15.23357  1.000 18.59478 ? 669 TYR   A H    1 
ATOM   6193 H HA   . TYR   B 1 191 ? -2.66988  -4.73431  17.63796  1.000 16.91361 ? 669 TYR   A HA   1 
ATOM   6194 H HB2  . TYR   B 1 191 ? -3.51408  -2.66099  17.04204  1.000 19.83385 ? 669 TYR   A HB2  1 
ATOM   6195 H HB3  . TYR   B 1 191 ? -3.99634  -3.24550  15.64519  1.000 19.83385 ? 669 TYR   A HB3  1 
ATOM   6196 H HD1  . TYR   B 1 191 ? -4.64888  -3.45258  19.13176  1.000 18.45729 ? 669 TYR   A HD1  1 
ATOM   6197 H HD2  . TYR   B 1 191 ? -6.08746  -4.40692  15.49497  1.000 19.66481 ? 669 TYR   A HD2  1 
ATOM   6198 H HE1  . TYR   B 1 191 ? -6.65737  -4.06083  20.07421  1.000 18.51465 ? 669 TYR   A HE1  1 
ATOM   6199 H HE2  . TYR   B 1 191 ? -8.08156  -5.02162  16.47215  1.000 19.01562 ? 669 TYR   A HE2  1 
ATOM   6200 H HH   . TYR   B 1 191 ? -9.22285  -5.37015  18.35043  1.000 19.51619 ? 669 TYR   A HH   1 
ATOM   6201 N N    . PRO   B 1 192 ? -3.55057  -6.92413  16.72886  1.000 14.03318 ? 670 PRO   A N    1 
ATOM   6202 C CA   . PRO   B 1 192 ? -4.10050  -8.12851  16.10205  1.000 15.91594 ? 670 PRO   A CA   1 
ATOM   6203 C C    . PRO   B 1 192 ? -5.59449  -7.92403  15.85543  1.000 15.66974 ? 670 PRO   A C    1 
ATOM   6204 O O    . PRO   B 1 192 ? -6.36840  -7.75610  16.80709  1.000 16.59201 ? 670 PRO   A O    1 
ATOM   6205 C CB   . PRO   B 1 192 ? -3.81850  -9.23205  17.12035  1.000 16.23967 ? 670 PRO   A CB   1 
ATOM   6206 C CG   . PRO   B 1 192 ? -3.83165  -8.53509  18.44774  1.000 18.42619 ? 670 PRO   A CG   1 
ATOM   6207 C CD   . PRO   B 1 192 ? -3.41452  -7.07539  18.19587  1.000 15.17917 ? 670 PRO   A CD   1 
ATOM   6208 H HA   . PRO   B 1 192 ? -3.64072  -8.36919  15.28256  1.000 19.05314 ? 670 PRO   A HA   1 
ATOM   6209 H HB2  . PRO   B 1 192 ? -4.51130  -9.90948  17.07561  1.000 19.44162 ? 670 PRO   A HB2  1 
ATOM   6210 H HB3  . PRO   B 1 192 ? -2.95210  -9.63148  16.94509  1.000 19.44162 ? 670 PRO   A HB3  1 
ATOM   6211 H HG2  . PRO   B 1 192 ? -4.72562  -8.57241  18.82234  1.000 22.06545 ? 670 PRO   A HG2  1 
ATOM   6212 H HG3  . PRO   B 1 192 ? -3.20303  -8.96897  19.04565  1.000 22.06545 ? 670 PRO   A HG3  1 
ATOM   6213 H HD2  . PRO   B 1 192 ? -4.00561  -6.46318  18.66140  1.000 18.16902 ? 670 PRO   A HD2  1 
ATOM   6214 H HD3  . PRO   B 1 192 ? -2.49716  -6.92661  18.47372  1.000 18.16902 ? 670 PRO   A HD3  1 
ATOM   6215 N N    . GLU   B 1 193 ? -5.99742  -7.84558  14.59283  1.000 15.48287 ? 671 GLU   A N    1 
ATOM   6216 C CA   . GLU   B 1 193 ? -7.38144  -7.44087  14.28336  1.000 16.96934 ? 671 GLU   A CA   1 
ATOM   6217 C C    . GLU   B 1 193 ? -8.29445  -8.62003  13.99830  1.000 17.84147 ? 671 GLU   A C    1 
ATOM   6218 O O    . GLU   B 1 193 ? -9.47276  -8.59478  14.38244  1.000 16.78595 ? 671 GLU   A O    1 
ATOM   6219 C CB   . GLU   B 1 193 ? -7.39993  -6.46604  13.08917  1.000 19.23677 ? 671 GLU   A CB   1 
ATOM   6220 C CG   . GLU   B 1 193 ? -8.65760  -5.62967  13.01375  1.000 27.62305 ? 671 GLU   A CG   1 
ATOM   6221 C CD   . GLU   B 1 193 ? -8.63698  -4.58813  11.89817  1.000 30.40563 ? 671 GLU   A CD   1 
ATOM   6222 O OE1  . GLU   B 1 193 ? -7.72895  -4.62026  11.05529  1.000 29.10333 ? 671 GLU   A OE1  1 
ATOM   6223 O OE2  . GLU   B 1 193 ? -9.55716  -3.74694  11.87524  1.000 34.63299 ? 671 GLU   A OE2  1 
ATOM   6224 H H    . GLU   B 1 193 ? -5.50566  -8.01607  13.90821  1.000 18.53346 ? 671 GLU   A H    1 
ATOM   6225 H HA   . GLU   B 1 193 ? -7.74590  -6.96921  15.04861  1.000 20.31723 ? 671 GLU   A HA   1 
ATOM   6226 H HB2  . GLU   B 1 193 ? -6.64517  -5.86172  13.16686  1.000 23.03814 ? 671 GLU   A HB2  1 
ATOM   6227 H HB3  . GLU   B 1 193 ? -7.33275  -6.97678  12.26727  1.000 23.03814 ? 671 GLU   A HB3  1 
ATOM   6228 H HG2  . GLU   B 1 193 ? -9.41388  -6.21640  12.85663  1.000 33.10168 ? 671 GLU   A HG2  1 
ATOM   6229 H HG3  . GLU   B 1 193 ? -8.77121  -5.15999  13.85481  1.000 33.10168 ? 671 GLU   A HG3  1 
ATOM   6230 N N    . TYR   B 1 194 ? -7.81060  -9.61181  13.25941  1.000 15.14300 ? 672 TYR   A N    1 
ATOM   6231 C CA   . TYR   B 1 194 ? -8.56400  -10.83698 13.01073  1.000 14.83632 ? 672 TYR   A CA   1 
ATOM   6232 C C    . TYR   B 1 194 ? -7.68820  -12.05213 13.23880  1.000 15.38081 ? 672 TYR   A C    1 
ATOM   6233 O O    . TYR   B 1 194 ? -6.47947  -12.00766 13.01546  1.000 14.82382 ? 672 TYR   A O    1 
ATOM   6234 C CB   . TYR   B 1 194 ? -9.07832  -10.84762 11.56792  1.000 15.73026 ? 672 TYR   A CB   1 
ATOM   6235 C CG   . TYR   B 1 194 ? -10.01203 -9.70542  11.28125  1.000 16.35842 ? 672 TYR   A CG   1 
ATOM   6236 C CD1  . TYR   B 1 194 ? -11.36794 -9.80631  11.56742  1.000 16.43063 ? 672 TYR   A CD1  1 
ATOM   6237 C CD2  . TYR   B 1 194 ? -9.53464  -8.50816  10.79934  1.000 17.12883 ? 672 TYR   A CD2  1 
ATOM   6238 C CE1  . TYR   B 1 194 ? -12.22364 -8.73447  11.30439  1.000 16.45546 ? 672 TYR   A CE1  1 
ATOM   6239 C CE2  . TYR   B 1 194 ? -10.36854 -7.42512  10.55618  1.000 17.88254 ? 672 TYR   A CE2  1 
ATOM   6240 C CZ   . TYR   B 1 194 ? -11.71370 -7.55823  10.82597  1.000 19.69124 ? 672 TYR   A CZ   1 
ATOM   6241 O OH   . TYR   B 1 194 ? -12.53250 -6.49974  10.59528  1.000 19.03808 ? 672 TYR   A OH   1 
ATOM   6242 H H    . TYR   B 1 194 ? -7.03643  -9.59958  12.88510  1.000 18.12561 ? 672 TYR   A H    1 
ATOM   6243 H HA   . TYR   B 1 194 ? -9.30657  -10.89614 13.63202  1.000 17.75760 ? 672 TYR   A HA   1 
ATOM   6244 H HB2  . TYR   B 1 194 ? -8.32372  -10.77925 10.96228  1.000 18.83033 ? 672 TYR   A HB2  1 
ATOM   6245 H HB3  . TYR   B 1 194 ? -9.55754  -11.67581 11.40871  1.000 18.83033 ? 672 TYR   A HB3  1 
ATOM   6246 H HD1  . TYR   B 1 194 ? -11.70681 -10.59032 11.93539  1.000 19.67077 ? 672 TYR   A HD1  1 
ATOM   6247 H HD2  . TYR   B 1 194 ? -8.62408  -8.42171  10.63112  1.000 20.50861 ? 672 TYR   A HD2  1 
ATOM   6248 H HE1  . TYR   B 1 194 ? -13.13755 -8.81986  11.45397  1.000 19.70057 ? 672 TYR   A HE1  1 
ATOM   6249 H HE2  . TYR   B 1 194 ? -10.02746 -6.62829  10.21909  1.000 21.41307 ? 672 TYR   A HE2  1 
ATOM   6250 H HH   . TYR   B 1 194 ? -13.32236 -6.69709  10.80210  1.000 22.79971 ? 672 TYR   A HH   1 
ATOM   6251 N N    . LEU   B 1 195 ? -8.32337  -13.14541 13.66535  1.000 14.72892 ? 673 LEU   A N    1 
ATOM   6252 C CA   . LEU   B 1 195 ? -7.68579  -14.45367 13.81731  1.000 14.37846 ? 673 LEU   A CA   1 
ATOM   6253 C C    . LEU   B 1 195 ? -8.35581  -15.40590 12.84802  1.000 17.18563 ? 673 LEU   A C    1 
ATOM   6254 O O    . LEU   B 1 195 ? -9.58265  -15.59935 12.91528  1.000 15.97934 ? 673 LEU   A O    1 
ATOM   6255 C CB   . LEU   B 1 195 ? -7.81059  -14.99794 15.23508  1.000 14.20760 ? 673 LEU   A CB   1 
ATOM   6256 C CG   . LEU   B 1 195 ? -7.27373  -16.41853 15.47379  1.000 15.70178 ? 673 LEU   A CG   1 
ATOM   6257 C CD1  . LEU   B 1 195 ? -5.81559  -16.52842 15.17029  1.000 15.69085 ? 673 LEU   A CD1  1 
ATOM   6258 C CD2  . LEU   B 1 195 ? -7.56411  -16.86373 16.92895  1.000 18.56986 ? 673 LEU   A CD2  1 
ATOM   6259 H H    . LEU   B 1 195 ? -9.15589  -13.15367 13.88085  1.000 17.62872 ? 673 LEU   A H    1 
ATOM   6260 H HA   . LEU   B 1 195 ? -6.74135  -14.37104 13.61212  1.000 17.20817 ? 673 LEU   A HA   1 
ATOM   6261 H HB2  . LEU   B 1 195 ? -7.32297  -14.40543 15.82842  1.000 17.00314 ? 673 LEU   A HB2  1 
ATOM   6262 H HB3  . LEU   B 1 195 ? -8.75104  -15.00491 15.47257  1.000 17.00314 ? 673 LEU   A HB3  1 
ATOM   6263 H HG   . LEU   B 1 195 ? -7.73167  -17.01965 14.86564  1.000 18.79615 ? 673 LEU   A HG   1 
ATOM   6264 H HD11 . LEU   B 1 195 ? -5.50283  -17.40700 15.43708  1.000 18.78303 ? 673 LEU   A HD11 1 
ATOM   6265 H HD12 . LEU   B 1 195 ? -5.68109  -16.40462 14.21768  1.000 18.78303 ? 673 LEU   A HD12 1 
ATOM   6266 H HD13 . LEU   B 1 195 ? -5.33784  -15.84336 15.66359  1.000 18.78303 ? 673 LEU   A HD13 1 
ATOM   6267 H HD21 . LEU   B 1 195 ? -7.21764  -17.76022 17.06001  1.000 22.23784 ? 673 LEU   A HD21 1 
ATOM   6268 H HD22 . LEU   B 1 195 ? -7.12949  -16.24851 17.54011  1.000 22.23784 ? 673 LEU   A HD22 1 
ATOM   6269 H HD23 . LEU   B 1 195 ? -8.52276  -16.85473 17.07662  1.000 22.23784 ? 673 LEU   A HD23 1 
ATOM   6270 N N    . ILE   B 1 196 ? -7.56114  -15.98739 11.96180  1.000 15.49072 ? 674 ILE   A N    1 
ATOM   6271 C CA   . ILE   B 1 196 ? -8.04082  -16.96989 10.98799  1.000 16.73757 ? 674 ILE   A CA   1 
ATOM   6272 C C    . ILE   B 1 196 ? -7.62265  -18.34242 11.48347  1.000 16.61962 ? 674 ILE   A C    1 
ATOM   6273 O O    . ILE   B 1 196 ? -6.43511  -18.59982 11.71898  1.000 16.12103 ? 674 ILE   A O    1 
ATOM   6274 C CB   . ILE   B 1 196 ? -7.46531  -16.68182 9.59661   1.000 15.32779 ? 674 ILE   A CB   1 
ATOM   6275 C CG1  . ILE   B 1 196 ? -7.86828  -15.28600 9.12529   1.000 15.60648 ? 674 ILE   A CG1  1 
ATOM   6276 C CG2  . ILE   B 1 196 ? -7.94886  -17.73493 8.57728   1.000 18.49951 ? 674 ILE   A CG2  1 
ATOM   6277 C CD1  . ILE   B 1 196 ? -7.20647  -14.85240 7.83292   1.000 18.14378 ? 674 ILE   A CD1  1 
ATOM   6278 H H    . ILE   B 1 196 ? -6.71828  -15.82822 11.89975  1.000 18.54288 ? 674 ILE   A H    1 
ATOM   6279 H HA   . ILE   B 1 196 ? -9.00882  -16.94305 10.93171  1.000 20.03910 ? 674 ILE   A HA   1 
ATOM   6280 H HB   . ILE   B 1 196 ? -6.49852  -16.72573 9.66204   1.000 18.34737 ? 674 ILE   A HB   1 
ATOM   6281 H HG12 . ILE   B 1 196 ? -8.82781  -15.27123 8.98394   1.000 18.68179 ? 674 ILE   A HG12 1 
ATOM   6282 H HG13 . ILE   B 1 196 ? -7.62399  -14.64453 9.81067   1.000 18.68179 ? 674 ILE   A HG13 1 
ATOM   6283 H HG21 . ILE   B 1 196 ? -7.61179  -17.50160 7.69817   1.000 22.15343 ? 674 ILE   A HG21 1 
ATOM   6284 H HG22 . ILE   B 1 196 ? -7.61284  -18.60617 8.83985   1.000 22.15343 ? 674 ILE   A HG22 1 
ATOM   6285 H HG23 . ILE   B 1 196 ? -8.91878  -17.74350 8.56810   1.000 22.15343 ? 674 ILE   A HG23 1 
ATOM   6286 H HD11 . ILE   B 1 196 ? -7.36198  -13.90405 7.70118   1.000 21.72655 ? 674 ILE   A HD11 1 
ATOM   6287 H HD12 . ILE   B 1 196 ? -6.25402  -15.02633 7.89202   1.000 21.72655 ? 674 ILE   A HD12 1 
ATOM   6288 H HD13 . ILE   B 1 196 ? -7.58963  -15.35572 7.09756   1.000 21.72655 ? 674 ILE   A HD13 1 
ATOM   6289 N N    . THR   B 1 197 ? -8.58517  -19.23744 11.62680  1.000 17.19024 ? 675 THR   A N    1 
ATOM   6290 C CA   . THR   B 1 197 ? -8.31971  -20.64488 11.91763  1.000 19.12399 ? 675 THR   A CA   1 
ATOM   6291 C C    . THR   B 1 197 ? -8.57331  -21.43638 10.64595  1.000 18.63866 ? 675 THR   A C    1 
ATOM   6292 O O    . THR   B 1 197 ? -9.65290  -21.30389 10.05486  1.000 20.29550 ? 675 THR   A O    1 
ATOM   6293 C CB   . THR   B 1 197 ? -9.22600  -21.13573 13.04941  1.000 21.71268 ? 675 THR   A CB   1 
ATOM   6294 O OG1  . THR   B 1 197 ? -9.04652  -20.30002 14.21153  1.000 21.74721 ? 675 THR   A OG1  1 
ATOM   6295 C CG2  . THR   B 1 197 ? -8.91437  -22.54256 13.45147  1.000 21.43074 ? 675 THR   A CG2  1 
ATOM   6296 H H    . THR   B 1 197 ? -9.42252  -19.05338 11.55925  1.000 20.58230 ? 675 THR   A H    1 
ATOM   6297 H HA   . THR   B 1 197 ? -7.39946  -20.77718 12.19425  1.000 22.90280 ? 675 THR   A HA   1 
ATOM   6298 H HB   . THR   B 1 197 ? -10.14188 -21.10191 12.73171  1.000 26.00924 ? 675 THR   A HB   1 
ATOM   6299 H HG1  . THR   B 1 197 ? -9.25921  -19.50766 14.03120  1.000 26.05067 ? 675 THR   A HG1  1 
ATOM   6300 H HG21 . THR   B 1 197 ? -9.44317  -22.79121 14.22571  1.000 25.67090 ? 675 THR   A HG21 1 
ATOM   6301 H HG22 . THR   B 1 197 ? -9.11900  -23.14898 12.72258  1.000 25.67090 ? 675 THR   A HG22 1 
ATOM   6302 H HG23 . THR   B 1 197 ? -7.97362  -22.62347 13.67361  1.000 25.67090 ? 675 THR   A HG23 1 
ATOM   6303 N N    . PHE   B 1 198 ? -7.58245  -22.23302 10.21978  1.000 19.55347 ? 676 PHE   A N    1 
ATOM   6304 C CA   . PHE   B 1 198 ? -7.62059  -22.85060 8.89742   1.000 19.49674 ? 676 PHE   A CA   1 
ATOM   6305 C C    . PHE   B 1 198 ? -6.83135  -24.14964 8.91907   1.000 23.23319 ? 676 PHE   A C    1 
ATOM   6306 O O    . PHE   B 1 198 ? -6.11571  -24.45089 9.87781   1.000 21.66996 ? 676 PHE   A O    1 
ATOM   6307 C CB   . PHE   B 1 198 ? -7.10494  -21.91513 7.81884   1.000 19.95328 ? 676 PHE   A CB   1 
ATOM   6308 C CG   . PHE   B 1 198 ? -5.62620  -21.55647 7.95930   1.000 19.28504 ? 676 PHE   A CG   1 
ATOM   6309 C CD1  . PHE   B 1 198 ? -5.19848  -20.71360 8.97937   1.000 20.34753 ? 676 PHE   A CD1  1 
ATOM   6310 C CD2  . PHE   B 1 198 ? -4.70809  -22.06581 7.08262   1.000 21.00250 ? 676 PHE   A CD2  1 
ATOM   6311 C CE1  . PHE   B 1 198 ? -3.87503  -20.37864 9.10640   1.000 18.67090 ? 676 PHE   A CE1  1 
ATOM   6312 C CE2  . PHE   B 1 198 ? -3.35634  -21.74537 7.20224   1.000 20.34671 ? 676 PHE   A CE2  1 
ATOM   6313 C CZ   . PHE   B 1 198 ? -2.93928  -20.90638 8.21029   1.000 20.94297 ? 676 PHE   A CZ   1 
ATOM   6314 H H    . PHE   B 1 198 ? -6.88245  -22.42711 10.68014  1.000 23.41818 ? 676 PHE   A H    1 
ATOM   6315 H HA   . PHE   B 1 198 ? -8.54259  -23.06835 8.68908   1.000 23.35010 ? 676 PHE   A HA   1 
ATOM   6316 H HB2  . PHE   B 1 198 ? -7.22416  -22.34085 6.95544   1.000 23.89795 ? 676 PHE   A HB2  1 
ATOM   6317 H HB3  . PHE   B 1 198 ? -7.61306  -21.08965 7.85470   1.000 23.89795 ? 676 PHE   A HB3  1 
ATOM   6318 H HD1  . PHE   B 1 198 ? -5.81819  -20.37270 9.58323   1.000 24.37105 ? 676 PHE   A HD1  1 
ATOM   6319 H HD2  . PHE   B 1 198 ? -4.98829  -22.63161 6.39980   1.000 25.15701 ? 676 PHE   A HD2  1 
ATOM   6320 H HE1  . PHE   B 1 198 ? -3.60099  -19.80397 9.78431   1.000 22.35909 ? 676 PHE   A HE1  1 
ATOM   6321 H HE2  . PHE   B 1 198 ? -2.73861  -22.09745 6.60279   1.000 24.37007 ? 676 PHE   A HE2  1 
ATOM   6322 H HZ   . PHE   B 1 198 ? -2.03859  -20.69101 8.29548   1.000 25.08558 ? 676 PHE   A HZ   1 
ATOM   6323 N N    . THR   B 1 199 ? -6.98837  -24.93006 7.83726   1.000 22.85998 ? 677 THR   A N    1 
ATOM   6324 C CA   . THR   B 1 199 ? -6.25787  -26.18257 7.68075   1.000 26.25603 ? 677 THR   A CA   1 
ATOM   6325 C C    . THR   B 1 199 ? -5.71596  -26.28300 6.26713   1.000 24.66104 ? 677 THR   A C    1 
ATOM   6326 O O    . THR   B 1 199 ? -6.16520  -25.59351 5.34915   1.000 25.68618 ? 677 THR   A O    1 
ATOM   6327 C CB   . THR   B 1 199 ? -7.14846  -27.40069 7.96258   1.000 35.75238 ? 677 THR   A CB   1 
ATOM   6328 O OG1  . THR   B 1 199 ? -8.25085  -27.34581 7.06796   1.000 30.23069 ? 677 THR   A OG1  1 
ATOM   6329 C CG2  . THR   B 1 199 ? -7.65372  -27.40570 9.40429   1.000 34.10973 ? 677 THR   A CG2  1 
ATOM   6330 H H    . THR   B 1 199 ? -7.51558  -24.74852 7.18252   1.000 27.38599 ? 677 THR   A H    1 
ATOM   6331 H HA   . THR   B 1 199 ? -5.51277  -26.18480 8.30181   1.000 31.46125 ? 677 THR   A HA   1 
ATOM   6332 H HB   . THR   B 1 199 ? -6.64407  -28.22001 7.83928   1.000 42.85687 ? 677 THR   A HB   1 
ATOM   6333 H HG1  . THR   B 1 199 ? -8.75757  -28.00346 7.19574   1.000 36.23084 ? 677 THR   A HG1  1 
ATOM   6334 H HG21 . THR   B 1 199 ? -8.20375  -28.18929 9.56035   1.000 40.88569 ? 677 THR   A HG21 1 
ATOM   6335 H HG22 . THR   B 1 199 ? -6.90331  -27.42037 10.01877  1.000 40.88569 ? 677 THR   A HG22 1 
ATOM   6336 H HG23 . THR   B 1 199 ? -8.18325  -26.61070 9.57302   1.000 40.88569 ? 677 THR   A HG23 1 
ATOM   6337 N N    . ALA   B 1 200 ? -4.74762  -27.17086 6.09303   1.000 29.56195 ? 678 ALA   A N    1 
ATOM   6338 C CA   . ALA   B 1 200 ? -4.08041  -27.31120 4.80093   1.000 36.74314 ? 678 ALA   A CA   1 
ATOM   6339 C C    . ALA   B 1 200 ? -4.90572  -28.16090 3.82853   1.000 34.08195 ? 678 ALA   A C    1 
ATOM   6340 O O    . ALA   B 1 200 ? -5.74820  -28.95512 4.24780   1.000 27.86341 ? 678 ALA   A O    1 
ATOM   6341 C CB   . ALA   B 1 200 ? -2.69829  -27.92858 4.98617   1.000 37.52855 ? 678 ALA   A CB   1 
ATOM   6342 O OXT  . ALA   B 1 200 ? -4.70729  -28.05986 2.60646   1.000 32.01315 ? 678 ALA   A OXT  1 
ATOM   6343 H H    . ALA   B 1 200 ? -4.45762  -27.70309 6.70314   1.000 35.42835 ? 678 ALA   A H    1 
ATOM   6344 H HA   . ALA   B 1 200 ? -3.97775  -26.42867 4.41170   1.000 44.04578 ? 678 ALA   A HA   1 
ATOM   6345 H HB1  . ALA   B 1 200 ? -2.26979  -28.00935 4.11970   1.000 44.98828 ? 678 ALA   A HB1  1 
ATOM   6346 H HB2  . ALA   B 1 200 ? -2.17095  -27.35482 5.56377   1.000 44.98828 ? 678 ALA   A HB2  1 
ATOM   6347 H HB3  . ALA   B 1 200 ? -2.79550  -28.80509 5.39011   1.000 44.98828 ? 678 ALA   A HB3  1 
HETATM 6348 S S    . DMS   C 2 .   ? 19.11698  -0.24879  38.69246  1.000 35.86275 ? 701 DMS   B S    1 
HETATM 6349 O O    . DMS   C 2 .   ? 19.55474  1.02480   39.27028  1.000 58.45327 ? 701 DMS   B O    1 
HETATM 6350 C C1   . DMS   C 2 .   ? 19.83659  -1.69558  39.50101  1.000 43.48093 ? 701 DMS   B C1   1 
HETATM 6351 C C2   . DMS   C 2 .   ? 19.70591  -0.50548  37.00008  1.000 23.44649 ? 701 DMS   B C2   1 
HETATM 6352 H H11  . DMS   C 2 .   ? 20.28519  -2.32062  38.77331  1.000 52.13113 ? 701 DMS   B H11  1 
HETATM 6353 H H12  . DMS   C 2 .   ? 19.07662  -2.23248  40.00665  1.000 52.13113 ? 701 DMS   B H12  1 
HETATM 6354 H H13  . DMS   C 2 .   ? 20.57031  -1.38280  40.19765  1.000 52.13113 ? 701 DMS   B H13  1 
HETATM 6355 H H21  . DMS   C 2 .   ? 19.36791  -1.44487  36.64683  1.000 28.08980 ? 701 DMS   B H21  1 
HETATM 6356 H H22  . DMS   C 2 .   ? 20.76462  -0.48417  36.98716  1.000 28.08980 ? 701 DMS   B H22  1 
HETATM 6357 H H23  . DMS   C 2 .   ? 19.33023  0.26221   36.37479  1.000 28.08980 ? 701 DMS   B H23  1 
HETATM 6358 C C1   . MPD   D 3 .   ? 2.98761   -14.63950 18.90195  1.000 31.59483 ? 701 MPD   A C1   1 
HETATM 6359 C C2   . MPD   D 3 .   ? 4.41918   -15.02125 18.61495  1.000 34.93714 ? 701 MPD   A C2   1 
HETATM 6360 O O2   . MPD   D 3 .   ? 4.46296   -15.76444 17.34757  1.000 26.78820 ? 701 MPD   A O2   1 
HETATM 6361 C CM   . MPD   D 3 .   ? 4.92406   -15.90626 19.74840  1.000 35.27869 ? 701 MPD   A CM   1 
HETATM 6362 C C3   . MPD   D 3 .   ? 5.23463   -13.73354 18.46879  1.000 37.28336 ? 701 MPD   A C3   1 
HETATM 6363 C C4   . MPD   D 3 .   ? 6.73669   -13.98307 18.43420  1.000 44.09784 ? 701 MPD   A C4   1 
HETATM 6364 O O4   . MPD   D 3 .   ? 7.04467   -14.77859 17.30725  1.000 42.08589 ? 701 MPD   A O4   1 
HETATM 6365 C C5   . MPD   D 3 .   ? 7.51969   -12.64459 18.35877  1.000 30.75535 ? 701 MPD   A C5   1 
HETATM 6366 H H11  . MPD   D 3 .   ? 2.82737   -13.59712 18.62653  1.000 37.86781 ? 701 MPD   A H11  1 
HETATM 6367 H H12  . MPD   D 3 .   ? 2.78279   -14.77019 19.96452  1.000 37.86781 ? 701 MPD   A H12  1 
HETATM 6368 H H13  . MPD   D 3 .   ? 2.31877   -15.27549 18.32206  1.000 37.86781 ? 701 MPD   A H13  1 
HETATM 6369 H HO2  . MPD   D 3 .   ? 3.61423   -15.64862 16.87150  1.000 32.09985 ? 701 MPD   A HO2  1 
HETATM 6370 H HM1  . MPD   D 3 .   ? 5.36500   -15.28351 20.52676  1.000 42.28845 ? 701 MPD   A HM1  1 
HETATM 6371 H HM2  . MPD   D 3 .   ? 4.09160   -16.47339 20.16491  1.000 42.28845 ? 701 MPD   A HM2  1 
HETATM 6372 H HM3  . MPD   D 3 .   ? 5.67662   -16.59478 19.36411  1.000 42.28845 ? 701 MPD   A HM3  1 
HETATM 6373 H H31  . MPD   D 3 .   ? 5.00449   -13.07167 19.30369  1.000 44.69405 ? 701 MPD   A H31  1 
HETATM 6374 H H32  . MPD   D 3 .   ? 4.93800   -13.22869 17.54942  1.000 44.69405 ? 701 MPD   A H32  1 
HETATM 6375 H H4   . MPD   D 3 .   ? 7.03183   -14.50183 19.34627  1.000 52.87142 ? 701 MPD   A H4   1 
HETATM 6376 H HO4  . MPD   D 3 .   ? 8.01152   -14.96985 17.30273  1.000 50.45708 ? 701 MPD   A HO4  1 
HETATM 6377 H H51  . MPD   D 3 .   ? 8.18517   -12.66111 17.49566  1.000 36.86044 ? 701 MPD   A H51  1 
HETATM 6378 H H52  . MPD   D 3 .   ? 8.10693   -12.51548 19.26794  1.000 36.86044 ? 701 MPD   A H52  1 
HETATM 6379 H H53  . MPD   D 3 .   ? 6.81668   -11.81750 18.25977  1.000 36.86044 ? 701 MPD   A H53  1 
HETATM 6380 C C10  . A1H44 E 4 .   ? 5.27887   -15.01348 10.83808  1.000 20.52932 ? 702 A1H44 A C10  1 
HETATM 6381 C C11  . A1H44 E 4 .   ? 6.83620   -16.96649 13.62564  1.000 33.10389 ? 702 A1H44 A C11  1 
HETATM 6382 C C14  . A1H44 E 4 .   ? 5.75814   -17.08599 14.52496  1.000 27.71463 ? 702 A1H44 A C14  1 
HETATM 6383 C C15  . A1H44 E 4 .   ? 5.87872   -17.92245 15.63600  1.000 35.44627 ? 702 A1H44 A C15  1 
HETATM 6384 C C16  . A1H44 E 4 .   ? 7.06740   -18.62887 15.86178  1.000 42.86347 ? 702 A1H44 A C16  1 
HETATM 6385 C C17  . A1H44 E 4 .   ? 8.13463   -18.50592 14.96940  1.000 34.77217 ? 702 A1H44 A C17  1 
HETATM 6386 C C20  . A1H44 E 4 .   ? 8.18075   -20.68463 16.84215  1.000 39.83021 ? 702 A1H44 A C20  1 
HETATM 6387 C C21  . A1H44 E 4 .   ? 7.66758   -18.73368 18.31393  1.000 48.89110 ? 702 A1H44 A C21  1 
HETATM 6388 C C22  . A1H44 E 4 .   ? 5.81205   -20.16190 17.40857  1.000 44.01662 ? 702 A1H44 A C22  1 
HETATM 6389 C C01  . A1H44 E 4 .   ? 6.22980   -13.77051 9.01372   1.000 21.18498 ? 702 A1H44 A C01  1 
HETATM 6390 C C02  . A1H44 E 4 .   ? 7.34792   -13.35873 8.31692   1.000 25.91754 ? 702 A1H44 A C02  1 
HETATM 6391 C C03  . A1H44 E 4 .   ? 8.61467   -13.72232 8.74143   1.000 25.48643 ? 702 A1H44 A C03  1 
HETATM 6392 C C04  . A1H44 E 4 .   ? 8.74978   -14.48372 9.87675   1.000 24.82585 ? 702 A1H44 A C04  1 
HETATM 6393 C C05  . A1H44 E 4 .   ? 7.62989   -14.90543 10.57431  1.000 24.17462 ? 702 A1H44 A C05  1 
HETATM 6394 C C06  . A1H44 E 4 .   ? 6.35460   -14.57525 10.14071  1.000 22.02904 ? 702 A1H44 A C06  1 
HETATM 6395 C C08  . A1H44 E 4 .   ? 6.68544   -16.06772 12.37571  1.000 29.65115 ? 702 A1H44 A C08  1 
HETATM 6396 C C18  . A1H44 E 4 .   ? 8.02771   -17.68185 13.85251  1.000 32.13325 ? 702 A1H44 A C18  1 
HETATM 6397 C C19  . A1H44 E 4 .   ? 7.18659   -19.55541 17.11696  1.000 48.29315 ? 702 A1H44 A C19  1 
HETATM 6398 C C23  . A1H44 E 4 .   ? 11.27599  -14.90440 9.61260   1.000 37.02574 ? 702 A1H44 A C23  1 
HETATM 6399 C C25  . A1H44 E 4 .   ? 12.53497  -15.44151 10.26718  1.000 42.94259 ? 702 A1H44 A C25  1 
HETATM 6400 C C26  . A1H44 E 4 .   ? 13.51597  -14.33894 10.62405  1.000 44.97594 ? 702 A1H44 A C26  1 
HETATM 6401 N N07  . A1H44 E 4 .   ? 7.78041   -15.66583 11.66864  1.000 28.82068 ? 702 A1H44 A N07  1 
HETATM 6402 N N09  . A1H44 E 4 .   ? 5.44847   -15.72153 11.95948  1.000 21.97297 ? 702 A1H44 A N09  1 
HETATM 6403 N N13  . A1H44 E 4 .   ? 10.03374  -14.91697 10.39899  1.000 37.11917 ? 702 A1H44 A N13  1 
HETATM 6404 O O12  . A1H44 E 4 .   ? 4.15783   -14.79736 10.47819  1.000 19.83768 ? 702 A1H44 A O12  1 
HETATM 6405 O O24  . A1H44 E 4 .   ? 11.31292  -14.50566 8.50733   1.000 40.62827 ? 702 A1H44 A O24  1 
HETATM 6406 O O27  . A1H44 E 4 .   ? 14.81759  -14.89028 10.68438  1.000 44.04751 ? 702 A1H44 A O27  1 
HETATM 6407 O O28  . A1H44 E 4 .   ? 12.11781  -16.15190 11.41158  1.000 37.25861 ? 702 A1H44 A O28  1 
HETATM 6408 H H141 . A1H44 E 4 .   ? 4.84177   -16.53235 14.35522  1.000 33.21157 ? 702 A1H44 A H141 1 
HETATM 6409 H H151 . A1H44 E 4 .   ? 5.04957   -18.02575 16.32658  1.000 42.48954 ? 702 A1H44 A H151 1 
HETATM 6410 H H171 . A1H44 E 4 .   ? 9.05022   -19.05443 15.14704  1.000 41.68062 ? 702 A1H44 A H171 1 
HETATM 6411 H H202 . A1H44 E 4 .   ? 7.96021   -21.13403 15.87840  1.000 47.75026 ? 702 A1H44 A H202 1 
HETATM 6412 H H201 . A1H44 E 4 .   ? 9.18994   -20.28358 16.83254  1.000 47.75026 ? 702 A1H44 A H201 1 
HETATM 6413 H H203 . A1H44 E 4 .   ? 8.09732   -21.43730 17.62056  1.000 47.75026 ? 702 A1H44 A H203 1 
HETATM 6414 H H211 . A1H44 E 4 .   ? 8.67007   -18.36187 18.11810  1.000 58.62334 ? 702 A1H44 A H211 1 
HETATM 6415 H H212 . A1H44 E 4 .   ? 7.68010   -19.36079 19.20170  1.000 58.62334 ? 702 A1H44 A H212 1 
HETATM 6416 H H213 . A1H44 E 4 .   ? 6.99389   -17.89527 18.47135  1.000 58.62334 ? 702 A1H44 A H213 1 
HETATM 6417 H H223 . A1H44 E 4 .   ? 5.92314   -20.99915 18.09760  1.000 52.77396 ? 702 A1H44 A H223 1 
HETATM 6418 H H222 . A1H44 E 4 .   ? 5.16874   -19.40497 17.85723  1.000 52.77396 ? 702 A1H44 A H222 1 
HETATM 6419 H H221 . A1H44 E 4 .   ? 5.36538   -20.51351 16.47854  1.000 52.77396 ? 702 A1H44 A H221 1 
HETATM 6420 H H011 . A1H44 E 4 .   ? 5.24193   -13.46237 8.67772   1.000 25.37599 ? 702 A1H44 A H011 1 
HETATM 6421 H H021 . A1H44 E 4 .   ? 7.23324   -12.74577 7.43025   1.000 31.05506 ? 702 A1H44 A H021 1 
HETATM 6422 H H031 . A1H44 E 4 .   ? 9.48602   -13.41092 8.18644   1.000 30.53773 ? 702 A1H44 A H031 1 
HETATM 6423 H H181 . A1H44 E 4 .   ? 8.85900   -17.59107 13.15960  1.000 38.51391 ? 702 A1H44 A H181 1 
HETATM 6424 H H251 . A1H44 E 4 .   ? 13.07129  -16.08660 9.57911   1.000 51.48513 ? 702 A1H44 A H251 1 
HETATM 6425 H H261 . A1H44 E 4 .   ? 13.25419  -13.91585 11.58713  1.000 53.92515 ? 702 A1H44 A H261 1 
HETATM 6426 H H262 . A1H44 E 4 .   ? 13.48328  -13.56314 9.86766   1.000 53.92515 ? 702 A1H44 A H262 1 
HETATM 6427 H H091 . A1H44 E 4 .   ? 4.64987   -15.99783 12.49605  1.000 26.32158 ? 702 A1H44 A H091 1 
HETATM 6428 H H131 . A1H44 E 4 .   ? 10.07513  -15.24152 11.34501  1.000 44.49702 ? 702 A1H44 A H131 1 
HETATM 6429 H H271 . A1H44 E 4 .   ? 14.77291  -15.78114 10.96756  1.000 52.81103 ? 702 A1H44 A H271 1 
HETATM 6430 H H281 . A1H44 E 4 .   ? 11.90808  -15.51651 12.09911  1.000 44.66435 ? 702 A1H44 A H281 1 
HETATM 6431 O O    . HOH   F 5 .   ? 29.33407  -1.78309  41.81152  1.000 24.49466 ? 801 HOH   B O    1 
HETATM 6432 O O    . HOH   F 5 .   ? 21.86231  6.36189   24.03456  1.000 21.08926 ? 802 HOH   B O    1 
HETATM 6433 O O    . HOH   F 5 .   ? 19.71140  1.91268   31.32401  1.000 30.85441 ? 803 HOH   B O    1 
HETATM 6434 O O    . HOH   F 5 .   ? 30.22888  14.15362  31.78770  1.000 24.17496 ? 804 HOH   B O    1 
HETATM 6435 O O    . HOH   F 5 .   ? -15.282   1.348     43.579    1.000 24.90650 ? 805 HOH   B O    1 
HETATM 6436 O O    . HOH   F 5 .   ? -2.87793  -9.66487  32.34784  1.000 21.87871 ? 806 HOH   B O    1 
HETATM 6437 O O    . HOH   F 5 .   ? 11.71561  -9.71536  28.74511  1.000 22.50335 ? 807 HOH   B O    1 
HETATM 6438 O O    . HOH   F 5 .   ? 29.792    18.404    39.159    1.000 15.69845 ? 808 HOH   B O    1 
HETATM 6439 O O    . HOH   F 5 .   ? 32.63072  11.05885  40.66870  1.000 27.62305 ? 809 HOH   B O    1 
HETATM 6440 O O    . HOH   F 5 .   ? 7.51881   15.78953  36.45721  1.000 21.88145 ? 810 HOH   B O    1 
HETATM 6441 O O    . HOH   F 5 .   ? 3.30935   -2.22567  26.55933  1.000 23.48504 ? 811 HOH   B O    1 
HETATM 6442 O O    . HOH   F 5 .   ? -7.943    -16.115   30.157    1.000 28.71107 ? 812 HOH   B O    1 
HETATM 6443 O O    . HOH   F 5 .   ? -3.15535  8.05110   33.40538  1.000 18.58671 ? 813 HOH   B O    1 
HETATM 6444 O O    . HOH   F 5 .   ? 25.85587  1.15132   27.06737  1.000 34.43300 ? 814 HOH   B O    1 
HETATM 6445 O O    . HOH   F 5 .   ? 21.94557  15.77358  31.19344  1.000 20.27904 ? 815 HOH   B O    1 
HETATM 6446 O O    . HOH   F 5 .   ? 18.400    27.985    43.630    1.000 29.70327 ? 816 HOH   B O    1 
HETATM 6447 O O    . HOH   F 5 .   ? -6.42528  6.27706   36.38996  1.000 25.55079 ? 817 HOH   B O    1 
HETATM 6448 O O    . HOH   F 5 .   ? 8.36083   0.69169   47.06159  1.000 26.85552 ? 818 HOH   B O    1 
HETATM 6449 O O    . HOH   F 5 .   ? 28.377    17.533    33.693    1.000 27.24920 ? 819 HOH   B O    1 
HETATM 6450 O O    . HOH   F 5 .   ? 9.02331   14.81538  34.18454  1.000 21.98052 ? 820 HOH   B O    1 
HETATM 6451 O O    . HOH   F 5 .   ? 24.39221  -5.36975  42.15168  1.000 26.43734 ? 821 HOH   B O    1 
HETATM 6452 O O    . HOH   F 5 .   ? 31.09030  5.66596   42.88092  1.000 29.77304 ? 822 HOH   B O    1 
HETATM 6453 O O    . HOH   F 5 .   ? 8.90084   5.31514   28.94715  1.000 27.12482 ? 823 HOH   B O    1 
HETATM 6454 O O    . HOH   F 5 .   ? 21.70516  -0.03813  34.49866  1.000 27.73804 ? 824 HOH   B O    1 
HETATM 6455 O O    . HOH   F 5 .   ? 26.41437  7.09385   34.80644  1.000 15.84223 ? 825 HOH   B O    1 
HETATM 6456 O O    . HOH   F 5 .   ? -3.70356  -8.88631  35.60552  1.000 25.37117 ? 826 HOH   B O    1 
HETATM 6457 O O    . HOH   F 5 .   ? 8.72717   0.11452   30.43971  1.000 23.02132 ? 827 HOH   B O    1 
HETATM 6458 O O    . HOH   F 5 .   ? 18.35384  26.05597  36.64560  1.000 29.66099 ? 828 HOH   B O    1 
HETATM 6459 O O    . HOH   F 5 .   ? 8.94382   25.50910  45.96712  1.000 25.23271 ? 829 HOH   B O    1 
HETATM 6460 O O    . HOH   F 5 .   ? 0.04961   4.68707   42.86980  1.000 28.04774 ? 830 HOH   B O    1 
HETATM 6461 O O    . HOH   F 5 .   ? 18.72345  15.97045  51.48717  1.000 29.67983 ? 831 HOH   B O    1 
HETATM 6462 O O    . HOH   F 5 .   ? -2.72275  -2.55828  29.83860  1.000 23.13122 ? 832 HOH   B O    1 
HETATM 6463 O O    . HOH   F 5 .   ? 14.55693  -6.87297  50.43950  1.000 24.20269 ? 833 HOH   B O    1 
HETATM 6464 O O    . HOH   F 5 .   ? 28.97132  11.86938  29.73315  1.000 27.70192 ? 834 HOH   B O    1 
HETATM 6465 O O    . HOH   F 5 .   ? 10.82147  0.54630   25.36408  1.000 27.46551 ? 835 HOH   B O    1 
HETATM 6466 O O    . HOH   F 5 .   ? 28.96305  6.25004   32.00931  1.000 18.91527 ? 836 HOH   B O    1 
HETATM 6467 O O    . HOH   F 5 .   ? 1.54102   9.25392   36.83357  1.000 16.43614 ? 837 HOH   B O    1 
HETATM 6468 O O    . HOH   F 5 .   ? 22.48925  -7.08050  43.30091  1.000 29.06279 ? 838 HOH   B O    1 
HETATM 6469 O O    . HOH   F 5 .   ? 7.96745   -9.26673  27.95715  1.000 20.72367 ? 839 HOH   B O    1 
HETATM 6470 O O    . HOH   F 5 .   ? 17.52491  -13.90440 34.31398  1.000 17.94200 ? 840 HOH   B O    1 
HETATM 6471 O O    . HOH   F 5 .   ? 12.55766  2.00027   24.56394  1.000 23.18755 ? 841 HOH   B O    1 
HETATM 6472 O O    . HOH   F 5 .   ? 22.35434  21.29786  41.84663  1.000 17.67092 ? 842 HOH   B O    1 
HETATM 6473 O O    . HOH   F 5 .   ? 0.55894   8.46783   40.93033  1.000 24.44483 ? 843 HOH   B O    1 
HETATM 6474 O O    . HOH   F 5 .   ? -0.10549  -5.16528  33.37060  1.000 23.61790 ? 844 HOH   B O    1 
HETATM 6475 O O    . HOH   F 5 .   ? 6.04854   -15.50448 42.83980  1.000 25.30402 ? 845 HOH   B O    1 
HETATM 6476 O O    . HOH   F 5 .   ? 3.84828   -15.26956 32.06106  1.000 27.66293 ? 846 HOH   B O    1 
HETATM 6477 O O    . HOH   F 5 .   ? 25.80193  2.97220   46.78451  1.000 21.84184 ? 847 HOH   B O    1 
HETATM 6478 O O    . HOH   F 5 .   ? 26.91022  14.23237  32.57294  1.000 25.24899 ? 848 HOH   B O    1 
HETATM 6479 O O    . HOH   F 5 .   ? 14.39022  -17.42950 46.83678  1.000 22.59232 ? 849 HOH   B O    1 
HETATM 6480 O O    . HOH   F 5 .   ? 26.32910  7.09075   50.39458  1.000 28.97732 ? 850 HOH   B O    1 
HETATM 6481 O O    . HOH   F 5 .   ? -3.77286  -15.88640 36.17588  1.000 15.84286 ? 851 HOH   B O    1 
HETATM 6482 O O    . HOH   F 5 .   ? -3.36346  -5.56725  35.87355  1.000 24.37272 ? 852 HOH   B O    1 
HETATM 6483 O O    . HOH   F 5 .   ? 22.35951  -1.99097  26.60992  1.000 31.50219 ? 853 HOH   B O    1 
HETATM 6484 O O    . HOH   F 5 .   ? 20.90418  15.74867  35.30585  1.000 14.46072 ? 854 HOH   B O    1 
HETATM 6485 O O    . HOH   F 5 .   ? -5.33294  -17.66896 29.87258  1.000 28.30767 ? 855 HOH   B O    1 
HETATM 6486 O O    . HOH   F 5 .   ? 16.86572  -0.70278  46.38770  1.000 17.34769 ? 856 HOH   B O    1 
HETATM 6487 O O    . HOH   F 5 .   ? 7.59618   12.32571  41.05085  1.000 18.64486 ? 857 HOH   B O    1 
HETATM 6488 O O    . HOH   F 5 .   ? -6.34106  -12.83192 30.54407  1.000 27.77934 ? 858 HOH   B O    1 
HETATM 6489 O O    . HOH   F 5 .   ? 11.70287  4.48366   46.09570  1.000 20.93498 ? 859 HOH   B O    1 
HETATM 6490 O O    . HOH   F 5 .   ? -2.04537  -7.75955  38.09533  1.000 18.76648 ? 860 HOH   B O    1 
HETATM 6491 O O    . HOH   F 5 .   ? 2.19921   -1.16051  43.24297  1.000 15.78499 ? 861 HOH   B O    1 
HETATM 6492 O O    . HOH   F 5 .   ? 28.33578  3.21337   45.34830  1.000 25.27257 ? 862 HOH   B O    1 
HETATM 6493 O O    . HOH   F 5 .   ? 10.67183  -2.82295  27.54889  1.000 17.40053 ? 863 HOH   B O    1 
HETATM 6494 O O    . HOH   F 5 .   ? 24.09013  -6.20454  38.80559  1.000 21.87234 ? 864 HOH   B O    1 
HETATM 6495 O O    . HOH   F 5 .   ? -2.34621  3.94580   40.62909  1.000 22.31828 ? 865 HOH   B O    1 
HETATM 6496 O O    . HOH   F 5 .   ? 25.600    -13.077   40.840    1.000 13.86126 ? 866 HOH   B O    1 
HETATM 6497 O O    . HOH   F 5 .   ? 7.90819   13.15882  22.66191  1.000 20.90654 ? 867 HOH   B O    1 
HETATM 6498 O O    . HOH   F 5 .   ? -8.729    -11.045   36.414    1.000 20.84292 ? 868 HOH   B O    1 
HETATM 6499 O O    . HOH   F 5 .   ? 17.08830  6.54937   48.46685  1.000 19.18727 ? 869 HOH   B O    1 
HETATM 6500 O O    . HOH   F 5 .   ? 8.92373   24.33959  34.89499  1.000 31.97050 ? 870 HOH   B O    1 
HETATM 6501 O O    . HOH   F 5 .   ? 18.433    22.177    48.020    1.000 33.26243 ? 871 HOH   B O    1 
HETATM 6502 O O    . HOH   F 5 .   ? 29.24635  1.96679   29.11825  1.000 34.13803 ? 872 HOH   B O    1 
HETATM 6503 O O    . HOH   F 5 .   ? 15.70760  -14.20681 46.99209  1.000 28.28778 ? 873 HOH   B O    1 
HETATM 6504 O O    . HOH   F 5 .   ? 2.12661   21.50990  29.69246  1.000 28.49436 ? 874 HOH   B O    1 
HETATM 6505 O O    . HOH   F 5 .   ? 24.18765  14.74667  32.67994  1.000 22.41492 ? 875 HOH   B O    1 
HETATM 6506 O O    . HOH   F 5 .   ? 16.10609  -1.51317  30.20044  1.000 27.38588 ? 876 HOH   B O    1 
HETATM 6507 O O    . HOH   F 5 .   ? -9.70715  6.20848   28.61792  1.000 31.06349 ? 877 HOH   B O    1 
HETATM 6508 O O    . HOH   F 5 .   ? 18.50049  -1.32181  48.48922  1.000 21.75820 ? 878 HOH   B O    1 
HETATM 6509 O O    . HOH   F 5 .   ? -1.25949  -1.14346  31.88748  1.000 23.89656 ? 879 HOH   B O    1 
HETATM 6510 O O    . HOH   F 5 .   ? -4.88824  -8.70414  41.70397  1.000 25.21143 ? 880 HOH   B O    1 
HETATM 6511 O O    . HOH   F 5 .   ? 6.87086   24.04810  37.34261  1.000 26.80160 ? 881 HOH   B O    1 
HETATM 6512 O O    . HOH   F 5 .   ? 6.23280   5.53788   28.20976  1.000 19.72696 ? 882 HOH   B O    1 
HETATM 6513 O O    . HOH   F 5 .   ? 9.53913   -16.77030 42.96280  1.000 19.06093 ? 883 HOH   B O    1 
HETATM 6514 O O    . HOH   F 5 .   ? 5.80642   -5.92183  33.46683  1.000 14.74222 ? 884 HOH   B O    1 
HETATM 6515 O O    . HOH   F 5 .   ? -2.669    -18.808   42.401    1.000 18.19099 ? 885 HOH   B O    1 
HETATM 6516 O O    . HOH   F 5 .   ? 28.79562  4.72214   28.80485  1.000 30.03755 ? 886 HOH   B O    1 
HETATM 6517 O O    . HOH   F 5 .   ? 23.19356  17.69908  30.16685  1.000 31.93393 ? 887 HOH   B O    1 
HETATM 6518 O O    . HOH   F 5 .   ? 16.53648  1.60481   27.48233  1.000 23.22867 ? 888 HOH   B O    1 
HETATM 6519 O O    . HOH   F 5 .   ? 21.37712  -0.41638  48.48125  1.000 22.48446 ? 889 HOH   B O    1 
HETATM 6520 O O    . HOH   F 5 .   ? 24.85518  0.50397   33.26550  1.000 31.66057 ? 890 HOH   B O    1 
HETATM 6521 O O    . HOH   F 5 .   ? 0.93995   3.82304   23.23625  1.000 21.14756 ? 891 HOH   B O    1 
HETATM 6522 O O    . HOH   F 5 .   ? -6.05095  -26.03960 33.47452  1.000 26.00085 ? 892 HOH   B O    1 
HETATM 6523 O O    . HOH   F 5 .   ? 16.35048  19.98204  26.36414  1.000 25.28759 ? 893 HOH   B O    1 
HETATM 6524 O O    . HOH   F 5 .   ? 16.78095  24.05870  31.69585  1.000 25.40411 ? 894 HOH   B O    1 
HETATM 6525 O O    . HOH   F 5 .   ? 14.67945  5.25460   49.20794  1.000 33.32081 ? 895 HOH   B O    1 
HETATM 6526 O O    . HOH   F 5 .   ? 7.06920   27.85885  30.18878  1.000 30.42308 ? 896 HOH   B O    1 
HETATM 6527 O O    . HOH   F 5 .   ? 10.61478  23.44114  40.10180  1.000 26.26356 ? 897 HOH   B O    1 
HETATM 6528 O O    . HOH   F 5 .   ? 13.58590  -8.66731  24.65009  1.000 21.53314 ? 898 HOH   B O    1 
HETATM 6529 O O    . HOH   F 5 .   ? 17.54415  -7.95090  33.01650  1.000 19.42710 ? 899 HOH   B O    1 
HETATM 6530 O O    . HOH   F 5 .   ? 9.67132   16.16879  42.20381  1.000 23.84385 ? 900 HOH   B O    1 
HETATM 6531 O O    . HOH   F 5 .   ? 8.31365   -15.94433 31.27316  1.000 21.29721 ? 901 HOH   B O    1 
HETATM 6532 O O    . HOH   F 5 .   ? 18.49820  -9.89046  35.04402  1.000 17.85603 ? 902 HOH   B O    1 
HETATM 6533 O O    . HOH   F 5 .   ? 20.22858  17.49799  28.93798  1.000 32.80745 ? 903 HOH   B O    1 
HETATM 6534 O O    . HOH   F 5 .   ? 16.87565  12.54784  53.23492  1.000 33.56251 ? 904 HOH   B O    1 
HETATM 6535 O O    . HOH   F 5 .   ? 4.62118   21.29818  27.99040  1.000 24.87213 ? 905 HOH   B O    1 
HETATM 6536 O O    . HOH   F 5 .   ? -6.28221  0.11419   40.64884  1.000 26.10592 ? 906 HOH   B O    1 
HETATM 6537 O O    . HOH   F 5 .   ? 0.33886   2.81192   25.84178  1.000 21.16565 ? 907 HOH   B O    1 
HETATM 6538 O O    . HOH   F 5 .   ? 9.95053   5.55748   21.88677  1.000 28.90713 ? 908 HOH   B O    1 
HETATM 6539 O O    . HOH   F 5 .   ? -6.93111  -11.73356 40.19372  1.000 26.65525 ? 909 HOH   B O    1 
HETATM 6540 O O    . HOH   F 5 .   ? 6.97615   5.29200   45.71278  1.000 20.53761 ? 910 HOH   B O    1 
HETATM 6541 O O    . HOH   F 5 .   ? 8.74248   -12.73450 48.78824  1.000 28.14548 ? 911 HOH   B O    1 
HETATM 6542 O O    . HOH   F 5 .   ? 12.99633  24.85748  39.40077  1.000 22.12910 ? 912 HOH   B O    1 
HETATM 6543 O O    . HOH   F 5 .   ? -5.58515  -10.35992 31.64488  1.000 28.91722 ? 913 HOH   B O    1 
HETATM 6544 O O    . HOH   F 5 .   ? 17.78791  -3.00236  34.02339  1.000 15.16959 ? 914 HOH   B O    1 
HETATM 6545 O O    . HOH   F 5 .   ? -14.110   6.115     30.033    1.000 20.97756 ? 915 HOH   B O    1 
HETATM 6546 O O    . HOH   F 5 .   ? 1.53559   -6.97159  45.25956  1.000 25.76217 ? 916 HOH   B O    1 
HETATM 6547 O O    . HOH   F 5 .   ? 20.69817  14.52349  29.08274  1.000 21.37492 ? 917 HOH   B O    1 
HETATM 6548 O O    . HOH   F 5 .   ? 36.783    16.032    34.748    1.000 28.75649 ? 918 HOH   B O    1 
HETATM 6549 O O    . HOH   F 5 .   ? 9.49641   2.28199   27.82252  1.000 19.45442 ? 919 HOH   B O    1 
HETATM 6550 O O    . HOH   F 5 .   ? 18.86531  13.93553  25.36004  1.000 21.77167 ? 920 HOH   B O    1 
HETATM 6551 O O    . HOH   F 5 .   ? 5.81322   -17.94482 34.61400  1.000 27.44007 ? 921 HOH   B O    1 
HETATM 6552 O O    . HOH   F 5 .   ? 23.84385  17.02470  47.10339  1.000 13.01882 ? 922 HOH   B O    1 
HETATM 6553 O O    . HOH   F 5 .   ? 0.34713   13.31045  37.16473  1.000 15.40022 ? 923 HOH   B O    1 
HETATM 6554 O O    . HOH   F 5 .   ? 5.90863   -15.92137 32.89338  1.000 21.44910 ? 924 HOH   B O    1 
HETATM 6555 O O    . HOH   F 5 .   ? 25.36586  5.12458   48.50460  1.000 28.51715 ? 925 HOH   B O    1 
HETATM 6556 O O    . HOH   F 5 .   ? 26.04039  16.77978  31.82305  1.000 30.40137 ? 926 HOH   B O    1 
HETATM 6557 O O    . HOH   F 5 .   ? 23.65252  -1.28828  47.23782  1.000 27.98336 ? 927 HOH   B O    1 
HETATM 6558 O O    . HOH   F 5 .   ? -8.65396  -20.47682 36.70275  1.000 22.04552 ? 928 HOH   B O    1 
HETATM 6559 O O    . HOH   F 5 .   ? -15.568   -0.956    44.675    1.000 33.31071 ? 929 HOH   B O    1 
HETATM 6560 O O    . HOH   G 5 .   ? -15.14408 -16.55802 18.90833  1.000 26.77407 ? 801 HOH   A O    1 
HETATM 6561 O O    . HOH   G 5 .   ? 2.59243   1.07970   24.76151  1.000 32.45381 ? 802 HOH   A O    1 
HETATM 6562 O O    . HOH   G 5 .   ? 5.67140   0.53792   22.68317  1.000 31.49083 ? 803 HOH   A O    1 
HETATM 6563 O O    . HOH   G 5 .   ? 5.83122   -6.19565  -1.36064  1.000 29.28405 ? 804 HOH   A O    1 
HETATM 6564 O O    . HOH   G 5 .   ? 13.42648  -3.01658  21.17587  1.000 20.77982 ? 805 HOH   A O    1 
HETATM 6565 O O    . HOH   G 5 .   ? 6.15374   7.28992   19.47236  1.000 28.29801 ? 806 HOH   A O    1 
HETATM 6566 O O    . HOH   G 5 .   ? 18.69645  -11.15901 15.53540  1.000 24.54847 ? 807 HOH   A O    1 
HETATM 6567 O O    . HOH   G 5 .   ? -1.95493  -1.35324  26.47149  1.000 28.94282 ? 808 HOH   A O    1 
HETATM 6568 O O    . HOH   G 5 .   ? -16.01385 -19.39205 3.68395   1.000 32.76469 ? 809 HOH   A O    1 
HETATM 6569 O O    . HOH   G 5 .   ? 4.21187   1.46878   20.40538  1.000 30.42261 ? 810 HOH   A O    1 
HETATM 6570 O O    . HOH   G 5 .   ? -10.10307 -7.94296  0.44030   1.000 30.16284 ? 811 HOH   A O    1 
HETATM 6571 O O    . HOH   G 5 .   ? -1.11286  -18.17588 25.22437  1.000 24.53981 ? 812 HOH   A O    1 
HETATM 6572 O O    . HOH   G 5 .   ? -12.32466 -15.37760 -1.10762  1.000 23.85431 ? 813 HOH   A O    1 
HETATM 6573 O O    . HOH   G 5 .   ? -0.13305  -25.02130 17.03138  1.000 26.61490 ? 814 HOH   A O    1 
HETATM 6574 O O    . HOH   G 5 .   ? -0.95492  6.39629   9.37049   1.000 26.07161 ? 815 HOH   A O    1 
HETATM 6575 O O    . HOH   G 5 .   ? 4.81035   1.97030   6.05458   1.000 20.74780 ? 816 HOH   A O    1 
HETATM 6576 O O    . HOH   G 5 .   ? 24.32259  -7.66930  11.97733  1.000 22.86288 ? 817 HOH   A O    1 
HETATM 6577 O O    . HOH   G 5 .   ? 18.41674  9.67472   12.78628  1.000 40.05155 ? 818 HOH   A O    1 
HETATM 6578 O O    . HOH   G 5 .   ? 20.44741  -2.86620  8.63283   1.000 28.94196 ? 819 HOH   A O    1 
HETATM 6579 O O    . HOH   G 5 .   ? -10.44425 -18.06893 14.26925  1.000 19.62689 ? 820 HOH   A O    1 
HETATM 6580 O O    . HOH   G 5 .   ? 14.69396  -6.27040  20.70102  1.000 22.46295 ? 821 HOH   A O    1 
HETATM 6581 O O    . HOH   G 5 .   ? -0.33429  -7.64063  3.29113   1.000 23.38999 ? 822 HOH   A O    1 
HETATM 6582 O O    . HOH   G 5 .   ? -20.74331 -9.06905  9.40902   1.000 26.92857 ? 823 HOH   A O    1 
HETATM 6583 O O    . HOH   G 5 .   ? -1.33907  -2.29407  20.94645  1.000 23.18440 ? 824 HOH   A O    1 
HETATM 6584 O O    . HOH   G 5 .   ? 1.17771   -5.84508  19.67250  1.000 27.29982 ? 825 HOH   A O    1 
HETATM 6585 O O    . HOH   G 5 .   ? -9.81836  -19.16175 18.22570  1.000 26.06973 ? 826 HOH   A O    1 
HETATM 6586 O O    . HOH   G 5 .   ? -5.84918  2.23641   12.66210  1.000 24.56057 ? 827 HOH   A O    1 
HETATM 6587 O O    . HOH   G 5 .   ? -20.04931 -11.22243 11.53563  1.000 26.84624 ? 828 HOH   A O    1 
HETATM 6588 O O    . HOH   G 5 .   ? -1.16228  -22.54500 14.45958  1.000 20.22244 ? 829 HOH   A O    1 
HETATM 6589 O O    . HOH   G 5 .   ? 8.52161   4.61517   15.79834  1.000 27.24755 ? 830 HOH   A O    1 
HETATM 6590 O O    . HOH   G 5 .   ? 10.67107  7.02551   11.16747  1.000 26.82432 ? 831 HOH   A O    1 
HETATM 6591 O O    . HOH   G 5 .   ? 2.51442   -16.92683 -2.36773  1.000 26.31418 ? 832 HOH   A O    1 
HETATM 6592 O O    . HOH   G 5 .   ? 3.78416   -21.32784 2.20724   1.000 27.25833 ? 833 HOH   A O    1 
HETATM 6593 O O    . HOH   G 5 .   ? -3.58979  -28.58915 8.45050   1.000 33.80999 ? 834 HOH   A O    1 
HETATM 6594 O O    . HOH   G 5 .   ? -8.92079  -21.10344 16.79945  1.000 31.74845 ? 835 HOH   A O    1 
HETATM 6595 O O    . HOH   G 5 .   ? 9.79051   -0.94524  15.70994  1.000 17.13456 ? 836 HOH   A O    1 
HETATM 6596 O O    . HOH   G 5 .   ? -22.905   -13.260   0.532     1.000 28.05670 ? 837 HOH   A O    1 
HETATM 6597 O O    . HOH   G 5 .   ? -10.42183 -6.00173  15.34650  1.000 26.54303 ? 838 HOH   A O    1 
HETATM 6598 O O    . HOH   G 5 .   ? 2.74004   -8.43472  24.95526  1.000 24.64054 ? 839 HOH   A O    1 
HETATM 6599 O O    . HOH   G 5 .   ? 4.51516   -5.08864  18.66577  1.000 27.40173 ? 840 HOH   A O    1 
HETATM 6600 O O    . HOH   G 5 .   ? 21.76902  -8.60680  19.36762  1.000 27.36875 ? 841 HOH   A O    1 
HETATM 6601 O O    . HOH   G 5 .   ? -5.010    -28.117   -0.381    1.000 24.45296 ? 842 HOH   A O    1 
HETATM 6602 O O    . HOH   G 5 .   ? 3.67968   -14.31540 -3.09565  1.000 26.10452 ? 843 HOH   A O    1 
HETATM 6603 O O    . HOH   G 5 .   ? 5.22923   -12.31595 2.65876   1.000 15.58386 ? 844 HOH   A O    1 
HETATM 6604 O O    . HOH   G 5 .   ? 1.36948   -22.07001 1.10829   1.000 29.60460 ? 845 HOH   A O    1 
HETATM 6605 O O    . HOH   G 5 .   ? -23.298   -4.380    18.372    1.000 24.97480 ? 846 HOH   A O    1 
HETATM 6606 O O    . HOH   G 5 .   ? 20.836    -7.822    6.365     1.000 22.98054 ? 847 HOH   A O    1 
HETATM 6607 O O    . HOH   G 5 .   ? -3.18369  10.70381  13.34927  1.000 24.85237 ? 848 HOH   A O    1 
HETATM 6608 O O    . HOH   G 5 .   ? 7.55002   -6.31679  21.44967  1.000 16.78922 ? 849 HOH   A O    1 
HETATM 6609 O O    . HOH   G 5 .   ? -2.23326  -13.00425 1.05813   1.000 17.76615 ? 850 HOH   A O    1 
HETATM 6610 O O    . HOH   G 5 .   ? -1.65197  12.37955  14.59913  1.000 26.62304 ? 851 HOH   A O    1 
HETATM 6611 O O    . HOH   G 5 .   ? -2.72348  -21.83105 -1.54279  1.000 22.45067 ? 852 HOH   A O    1 
HETATM 6612 O O    . HOH   G 5 .   ? -8.88848  -4.67780  26.69257  1.000 20.85461 ? 853 HOH   A O    1 
HETATM 6613 O O    . HOH   G 5 .   ? 5.10433   -25.36878 5.60794   1.000 34.08968 ? 854 HOH   A O    1 
HETATM 6614 O O    . HOH   G 5 .   ? 17.82816  0.04159   3.40487   1.000 28.64267 ? 855 HOH   A O    1 
HETATM 6615 O O    . HOH   G 5 .   ? 9.48833   -14.82244 13.79789  1.000 33.67342 ? 856 HOH   A O    1 
HETATM 6616 O O    . HOH   G 5 .   ? -3.84264  -18.61697 -3.72455  1.000 24.89734 ? 857 HOH   A O    1 
HETATM 6617 O O    . HOH   G 5 .   ? -18.39815 -13.14477 20.85661  1.000 31.34418 ? 858 HOH   A O    1 
HETATM 6618 O O    . HOH   G 5 .   ? 5.79976   -13.91130 0.44740   1.000 21.18208 ? 859 HOH   A O    1 
HETATM 6619 O O    . HOH   G 5 .   ? 3.23661   -12.12099 21.66457  1.000 24.77103 ? 860 HOH   A O    1 
HETATM 6620 O O    . HOH   G 5 .   ? 7.21355   -6.43824  18.80522  1.000 21.38934 ? 861 HOH   A O    1 
HETATM 6621 O O    . HOH   G 5 .   ? -6.97626  -14.69843 25.83333  1.000 28.15474 ? 862 HOH   A O    1 
HETATM 6622 O O    . HOH   G 5 .   ? 1.08525   -24.76785 20.34727  1.000 34.75188 ? 863 HOH   A O    1 
HETATM 6623 O O    . HOH   G 5 .   ? 7.90488   -13.03951 15.13331  1.000 18.03297 ? 864 HOH   A O    1 
HETATM 6624 O O    . HOH   G 5 .   ? -13.72053 -8.80309  28.71727  1.000 28.41318 ? 865 HOH   A O    1 
HETATM 6625 O O    . HOH   G 5 .   ? 12.43691  7.97191   16.76475  1.000 27.25418 ? 866 HOH   A O    1 
HETATM 6626 O O    . HOH   G 5 .   ? -16.18049 -17.40873 10.80349  1.000 19.34146 ? 867 HOH   A O    1 
HETATM 6627 O O    . HOH   G 5 .   ? -1.26824  4.01111   6.33369   1.000 28.96874 ? 868 HOH   A O    1 
HETATM 6628 O O    . HOH   G 5 .   ? -0.85356  -6.22154  27.48160  1.000 27.94116 ? 869 HOH   A O    1 
HETATM 6629 O O    . HOH   G 5 .   ? 10.11832  3.66169   4.13666   1.000 25.14631 ? 870 HOH   A O    1 
HETATM 6630 O O    . HOH   G 5 .   ? -18.79584 -10.84132 8.40752   1.000 23.70087 ? 871 HOH   A O    1 
HETATM 6631 O O    . HOH   G 5 .   ? -11.341   -24.478   0.964     1.000 24.15832 ? 872 HOH   A O    1 
HETATM 6632 O O    . HOH   G 5 .   ? 16.73163  -3.49873  0.47537   1.000 20.66844 ? 873 HOH   A O    1 
HETATM 6633 O O    . HOH   G 5 .   ? -18.68155 -14.94459 18.66914  1.000 27.61559 ? 874 HOH   A O    1 
HETATM 6634 O O    . HOH   G 5 .   ? -17.01935 -19.82317 10.14430  1.000 27.00804 ? 875 HOH   A O    1 
HETATM 6635 O O    . HOH   G 5 .   ? 19.98641  -2.23993  17.64376  1.000 21.43962 ? 876 HOH   A O    1 
HETATM 6636 O O    . HOH   G 5 .   ? -1.58814  -2.84873  3.63422   1.000 27.79622 ? 877 HOH   A O    1 
HETATM 6637 O O    . HOH   G 5 .   ? -8.81374  -17.69121 20.33231  1.000 21.16568 ? 878 HOH   A O    1 
HETATM 6638 O O    . HOH   G 5 .   ? 5.26928   -17.01705 0.58818   1.000 22.94861 ? 879 HOH   A O    1 
HETATM 6639 O O    . HOH   G 5 .   ? -20.11111 -7.05428  7.49032   1.000 24.01746 ? 880 HOH   A O    1 
HETATM 6640 O O    . HOH   G 5 .   ? -8.52523  -15.53087 24.08057  1.000 18.37196 ? 881 HOH   A O    1 
HETATM 6641 O O    . HOH   G 5 .   ? -6.695    -30.976   2.006     1.000 28.73836 ? 882 HOH   A O    1 
HETATM 6642 O O    . HOH   G 5 .   ? -22.23088 -6.61954  5.84083   1.000 30.63186 ? 883 HOH   A O    1 
HETATM 6643 O O    . HOH   G 5 .   ? -7.94405  -15.68442 27.68990  1.000 38.84626 ? 884 HOH   A O    1 
HETATM 6644 O O    . HOH   G 5 .   ? 18.61283  -1.52869  1.29310   1.000 31.19089 ? 885 HOH   A O    1 
# 
