data_9FC6
# 
_entry.id   9FC6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FC6         pdb_00009fc6 10.2210/pdb9fc6/pdb 
WWPDB D_1292137230 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-28 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FC6 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              alke.meents@desy.de 
_pdbx_contact_author.name_first         Alke 
_pdbx_contact_author.name_last          Meents 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6078-4095 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Reinke, P.Y.A.'       1  0000-0002-7354-0839 
'Guenther, S.'         2  ?                   
'Falke, S.'            3  ?                   
'Galchenkova, M.'      4  ?                   
'Rahmani Mashhour, A.' 5  ?                   
'Creon, A.'            6  ?                   
'Lieske, J.'           7  ?                   
'Ewert, W.'            8  ?                   
'Rorigues, A.C.'       9  ?                   
'Thekku Veedu, S.'     10 ?                   
'Fischer, P.'          11 ?                   
'Meents, A.'           12 0000-0001-6078-4095 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Exploring the conformational space of proteins by systematic variation of the relative humidity' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Reinke, P.Y.A.' 1 0000-0002-7354-0839 
primary 'Meents, A.'     2 0000-0001-6078-4095 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Lysozyme C'   14331.160 1   3.2.1.17 ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL 62.068    1   ?        ? ? ? 
3 non-polymer syn 'CHLORIDE ION' 35.453    2   ?        ? ? ? 
4 non-polymer syn 'SODIUM ION'   22.990    2   ?        ? ? ? 
5 water       nat water          18.015    111 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '1,4-beta-N-acetylmuramidase C,Allergen Gal d IV' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL EDO 
3 'CHLORIDE ION' CL  
4 'SODIUM ION'   NA  
5 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   VAL n 
1 3   PHE n 
1 4   GLY n 
1 5   ARG n 
1 6   CYS n 
1 7   GLU n 
1 8   LEU n 
1 9   ALA n 
1 10  ALA n 
1 11  ALA n 
1 12  MET n 
1 13  LYS n 
1 14  ARG n 
1 15  HIS n 
1 16  GLY n 
1 17  LEU n 
1 18  ASP n 
1 19  ASN n 
1 20  TYR n 
1 21  ARG n 
1 22  GLY n 
1 23  TYR n 
1 24  SER n 
1 25  LEU n 
1 26  GLY n 
1 27  ASN n 
1 28  TRP n 
1 29  VAL n 
1 30  CYS n 
1 31  ALA n 
1 32  ALA n 
1 33  LYS n 
1 34  PHE n 
1 35  GLU n 
1 36  SER n 
1 37  ASN n 
1 38  PHE n 
1 39  ASN n 
1 40  THR n 
1 41  GLN n 
1 42  ALA n 
1 43  THR n 
1 44  ASN n 
1 45  ARG n 
1 46  ASN n 
1 47  THR n 
1 48  ASP n 
1 49  GLY n 
1 50  SER n 
1 51  THR n 
1 52  ASP n 
1 53  TYR n 
1 54  GLY n 
1 55  ILE n 
1 56  LEU n 
1 57  GLN n 
1 58  ILE n 
1 59  ASN n 
1 60  SER n 
1 61  ARG n 
1 62  TRP n 
1 63  TRP n 
1 64  CYS n 
1 65  ASN n 
1 66  ASP n 
1 67  GLY n 
1 68  ARG n 
1 69  THR n 
1 70  PRO n 
1 71  GLY n 
1 72  SER n 
1 73  ARG n 
1 74  ASN n 
1 75  LEU n 
1 76  CYS n 
1 77  ASN n 
1 78  ILE n 
1 79  PRO n 
1 80  CYS n 
1 81  SER n 
1 82  ALA n 
1 83  LEU n 
1 84  LEU n 
1 85  SER n 
1 86  SER n 
1 87  ASP n 
1 88  ILE n 
1 89  THR n 
1 90  ALA n 
1 91  SER n 
1 92  VAL n 
1 93  ASN n 
1 94  CYS n 
1 95  ALA n 
1 96  LYS n 
1 97  LYS n 
1 98  ILE n 
1 99  VAL n 
1 100 SER n 
1 101 ASP n 
1 102 GLY n 
1 103 ASN n 
1 104 GLY n 
1 105 MET n 
1 106 ASN n 
1 107 ALA n 
1 108 TRP n 
1 109 VAL n 
1 110 ALA n 
1 111 TRP n 
1 112 ARG n 
1 113 ASN n 
1 114 ARG n 
1 115 CYS n 
1 116 LYS n 
1 117 GLY n 
1 118 THR n 
1 119 ASP n 
1 120 VAL n 
1 121 GLN n 
1 122 ALA n 
1 123 TRP n 
1 124 ILE n 
1 125 ARG n 
1 126 GLY n 
1 127 CYS n 
1 128 ARG n 
1 129 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   129 
_entity_src_gen.gene_src_common_name               chicken 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 LYZ 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Gallus gallus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9031 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Gallus gallus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9031 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ?                 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'    ?                 'Na 1'           22.990  
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   1   LYS LYS A . n 
A 1 2   VAL 2   2   2   VAL VAL A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   ARG 5   5   5   ARG ARG A . n 
A 1 6   CYS 6   6   6   CYS CYS A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  MET 12  12  12  MET MET A . n 
A 1 13  LYS 13  13  13  LYS LYS A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  HIS 15  15  15  HIS HIS A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ASP 18  18  18  ASP ASP A . n 
A 1 19  ASN 19  19  19  ASN ASN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  TYR 23  23  23  TYR TYR A . n 
A 1 24  SER 24  24  24  SER SER A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  ASN 27  27  27  ASN ASN A . n 
A 1 28  TRP 28  28  28  TRP TRP A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  CYS 30  30  30  CYS CYS A . n 
A 1 31  ALA 31  31  31  ALA ALA A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  PHE 34  34  34  PHE PHE A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  ASN 37  37  37  ASN ASN A . n 
A 1 38  PHE 38  38  38  PHE PHE A . n 
A 1 39  ASN 39  39  39  ASN ASN A . n 
A 1 40  THR 40  40  40  THR THR A . n 
A 1 41  GLN 41  41  41  GLN GLN A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  THR 43  43  43  THR THR A . n 
A 1 44  ASN 44  44  44  ASN ASN A . n 
A 1 45  ARG 45  45  45  ARG ARG A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  THR 47  47  47  THR THR A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  SER 50  50  50  SER SER A . n 
A 1 51  THR 51  51  51  THR THR A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  TYR 53  53  53  TYR TYR A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  ILE 58  58  58  ILE ILE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  TRP 62  62  62  TRP TRP A . n 
A 1 63  TRP 63  63  63  TRP TRP A . n 
A 1 64  CYS 64  64  64  CYS CYS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  ASP 66  66  66  ASP ASP A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  PRO 70  70  70  PRO PRO A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  CYS 76  76  76  CYS CYS A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  PRO 79  79  79  PRO PRO A . n 
A 1 80  CYS 80  80  80  CYS CYS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  SER 85  85  85  SER SER A . n 
A 1 86  SER 86  86  86  SER SER A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  ILE 88  88  88  ILE ILE A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  CYS 94  94  94  CYS CYS A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  ILE 98  98  98  ILE ILE A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 ASN 103 103 103 ASN ASN A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 MET 105 105 105 MET MET A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 ALA 107 107 107 ALA ALA A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 VAL 109 109 109 VAL VAL A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 TRP 111 111 111 TRP TRP A . n 
A 1 112 ARG 112 112 112 ARG ARG A . n 
A 1 113 ASN 113 113 113 ASN ASN A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 CYS 115 115 115 CYS CYS A . n 
A 1 116 LYS 116 116 116 LYS LYS A . n 
A 1 117 GLY 117 117 117 GLY GLY A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 ASP 119 119 119 ASP ASP A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 ALA 122 122 122 ALA ALA A . n 
A 1 123 TRP 123 123 123 TRP TRP A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 CYS 127 127 127 CYS CYS A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NA 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NA 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1   201 207 EDO EDO A . 
C 3 CL  1   202 2   CL  CL  A . 
D 3 CL  1   203 4   CL  CL  A . 
E 4 NA  1   204 1   NA  NA  A . 
F 4 NA  1   205 2   NA  NA  A . 
G 5 HOH 1   301 25  HOH HOH A . 
G 5 HOH 2   302 3   HOH HOH A . 
G 5 HOH 3   303 167 HOH HOH A . 
G 5 HOH 4   304 109 HOH HOH A . 
G 5 HOH 5   305 100 HOH HOH A . 
G 5 HOH 6   306 173 HOH HOH A . 
G 5 HOH 7   307 81  HOH HOH A . 
G 5 HOH 8   308 166 HOH HOH A . 
G 5 HOH 9   309 106 HOH HOH A . 
G 5 HOH 10  310 117 HOH HOH A . 
G 5 HOH 11  311 130 HOH HOH A . 
G 5 HOH 12  312 1   HOH HOH A . 
G 5 HOH 13  313 5   HOH HOH A . 
G 5 HOH 14  314 41  HOH HOH A . 
G 5 HOH 15  315 4   HOH HOH A . 
G 5 HOH 16  316 164 HOH HOH A . 
G 5 HOH 17  317 49  HOH HOH A . 
G 5 HOH 18  318 6   HOH HOH A . 
G 5 HOH 19  319 128 HOH HOH A . 
G 5 HOH 20  320 152 HOH HOH A . 
G 5 HOH 21  321 168 HOH HOH A . 
G 5 HOH 22  322 107 HOH HOH A . 
G 5 HOH 23  323 144 HOH HOH A . 
G 5 HOH 24  324 2   HOH HOH A . 
G 5 HOH 25  325 43  HOH HOH A . 
G 5 HOH 26  326 122 HOH HOH A . 
G 5 HOH 27  327 60  HOH HOH A . 
G 5 HOH 28  328 160 HOH HOH A . 
G 5 HOH 29  329 127 HOH HOH A . 
G 5 HOH 30  330 178 HOH HOH A . 
G 5 HOH 31  331 93  HOH HOH A . 
G 5 HOH 32  332 47  HOH HOH A . 
G 5 HOH 33  333 150 HOH HOH A . 
G 5 HOH 34  334 34  HOH HOH A . 
G 5 HOH 35  335 66  HOH HOH A . 
G 5 HOH 36  336 7   HOH HOH A . 
G 5 HOH 37  337 59  HOH HOH A . 
G 5 HOH 38  338 17  HOH HOH A . 
G 5 HOH 39  339 28  HOH HOH A . 
G 5 HOH 40  340 62  HOH HOH A . 
G 5 HOH 41  341 175 HOH HOH A . 
G 5 HOH 42  342 151 HOH HOH A . 
G 5 HOH 43  343 11  HOH HOH A . 
G 5 HOH 44  344 9   HOH HOH A . 
G 5 HOH 45  345 169 HOH HOH A . 
G 5 HOH 46  346 147 HOH HOH A . 
G 5 HOH 47  347 24  HOH HOH A . 
G 5 HOH 48  348 165 HOH HOH A . 
G 5 HOH 49  349 14  HOH HOH A . 
G 5 HOH 50  350 115 HOH HOH A . 
G 5 HOH 51  351 36  HOH HOH A . 
G 5 HOH 52  352 153 HOH HOH A . 
G 5 HOH 53  353 50  HOH HOH A . 
G 5 HOH 54  354 33  HOH HOH A . 
G 5 HOH 55  355 8   HOH HOH A . 
G 5 HOH 56  356 131 HOH HOH A . 
G 5 HOH 57  357 163 HOH HOH A . 
G 5 HOH 58  358 155 HOH HOH A . 
G 5 HOH 59  359 10  HOH HOH A . 
G 5 HOH 60  360 20  HOH HOH A . 
G 5 HOH 61  361 121 HOH HOH A . 
G 5 HOH 62  362 12  HOH HOH A . 
G 5 HOH 63  363 162 HOH HOH A . 
G 5 HOH 64  364 16  HOH HOH A . 
G 5 HOH 65  365 30  HOH HOH A . 
G 5 HOH 66  366 134 HOH HOH A . 
G 5 HOH 67  367 91  HOH HOH A . 
G 5 HOH 68  368 15  HOH HOH A . 
G 5 HOH 69  369 13  HOH HOH A . 
G 5 HOH 70  370 29  HOH HOH A . 
G 5 HOH 71  371 23  HOH HOH A . 
G 5 HOH 72  372 158 HOH HOH A . 
G 5 HOH 73  373 108 HOH HOH A . 
G 5 HOH 74  374 18  HOH HOH A . 
G 5 HOH 75  375 46  HOH HOH A . 
G 5 HOH 76  376 97  HOH HOH A . 
G 5 HOH 77  377 55  HOH HOH A . 
G 5 HOH 78  378 45  HOH HOH A . 
G 5 HOH 79  379 61  HOH HOH A . 
G 5 HOH 80  380 22  HOH HOH A . 
G 5 HOH 81  381 99  HOH HOH A . 
G 5 HOH 82  382 35  HOH HOH A . 
G 5 HOH 83  383 157 HOH HOH A . 
G 5 HOH 84  384 86  HOH HOH A . 
G 5 HOH 85  385 146 HOH HOH A . 
G 5 HOH 86  386 112 HOH HOH A . 
G 5 HOH 87  387 145 HOH HOH A . 
G 5 HOH 88  388 174 HOH HOH A . 
G 5 HOH 89  389 126 HOH HOH A . 
G 5 HOH 90  390 87  HOH HOH A . 
G 5 HOH 91  391 149 HOH HOH A . 
G 5 HOH 92  392 129 HOH HOH A . 
G 5 HOH 93  393 78  HOH HOH A . 
G 5 HOH 94  394 159 HOH HOH A . 
G 5 HOH 95  395 138 HOH HOH A . 
G 5 HOH 96  396 171 HOH HOH A . 
G 5 HOH 97  397 57  HOH HOH A . 
G 5 HOH 98  398 125 HOH HOH A . 
G 5 HOH 99  399 132 HOH HOH A . 
G 5 HOH 100 400 110 HOH HOH A . 
G 5 HOH 101 401 170 HOH HOH A . 
G 5 HOH 102 402 148 HOH HOH A . 
G 5 HOH 103 403 176 HOH HOH A . 
G 5 HOH 104 404 139 HOH HOH A . 
G 5 HOH 105 405 101 HOH HOH A . 
G 5 HOH 106 406 172 HOH HOH A . 
G 5 HOH 107 407 118 HOH HOH A . 
G 5 HOH 108 408 154 HOH HOH A . 
G 5 HOH 109 409 74  HOH HOH A . 
G 5 HOH 110 410 73  HOH HOH A . 
G 5 HOH 111 411 177 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FC6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     79.507 
_cell.length_a_esd                 ? 
_cell.length_b                     79.507 
_cell.length_b_esd                 ? 
_cell.length_c                     37.984 
_cell.length_c_esd                 ? 
_cell.volume                       240110.654 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FC6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FC6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.09 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.27 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              3.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1M NaCl, 35% (v/v) ethylene glycol, 20% (w/v) PEG4000, 50 mM sodium acetate pH 3.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     298 
_diffrn.ambient_temp_details             'Humidity chamber controlled' 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.7749 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P09 HiPhaX' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.7749 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P09 HiPhaX' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          22.72 
_reflns.entry_id                                       9FC6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.4 
_reflns.d_resolution_low                               34.27 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24529 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.89 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.98 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.4 
_reflns_shell.d_res_low                                     1.45 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.02 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2370 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.439 
_reflns_shell.pdbx_CC_star                                  0.781 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.73 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FC6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.40 
_refine.ls_d_res_low                             34.27 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24527 
_refine.ls_number_reflns_R_free                  2032 
_refine.ls_number_reflns_R_work                  22495 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.90 
_refine.ls_percent_reflns_R_free                 8.28 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1545 
_refine.ls_R_factor_R_free                       0.1872 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1515 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.1672 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1783 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.40 
_refine_hist.d_res_low                        34.27 
_refine_hist.number_atoms_solvent             111 
_refine_hist.number_atoms_total               1120 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1001 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0089 ? 1300 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9843 ? 1781 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0820 ? 172  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0081 ? 251  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.7406 ? 201  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.40 1.43  . . 130 1439 98.56  . . . . 0.3566 . . . . . . . . . . . 0.4151 
'X-RAY DIFFRACTION' 1.43 1.47  . . 131 1492 100.00 . . . . 0.2959 . . . . . . . . . . . 0.3459 
'X-RAY DIFFRACTION' 1.47 1.51  . . 137 1458 100.00 . . . . 0.2482 . . . . . . . . . . . 0.2281 
'X-RAY DIFFRACTION' 1.51 1.55  . . 131 1468 100.00 . . . . 0.2119 . . . . . . . . . . . 0.2396 
'X-RAY DIFFRACTION' 1.55 1.60  . . 131 1489 100.00 . . . . 0.1946 . . . . . . . . . . . 0.2229 
'X-RAY DIFFRACTION' 1.60 1.66  . . 137 1478 100.00 . . . . 0.1881 . . . . . . . . . . . 0.2041 
'X-RAY DIFFRACTION' 1.66 1.73  . . 131 1486 100.00 . . . . 0.1954 . . . . . . . . . . . 0.2096 
'X-RAY DIFFRACTION' 1.73 1.80  . . 134 1491 100.00 . . . . 0.1800 . . . . . . . . . . . 0.2138 
'X-RAY DIFFRACTION' 1.81 1.90  . . 139 1478 100.00 . . . . 0.1649 . . . . . . . . . . . 0.1736 
'X-RAY DIFFRACTION' 1.90 2.02  . . 132 1494 100.00 . . . . 0.1394 . . . . . . . . . . . 0.1770 
'X-RAY DIFFRACTION' 2.02 2.17  . . 138 1494 100.00 . . . . 0.1382 . . . . . . . . . . . 0.1749 
'X-RAY DIFFRACTION' 2.18 2.39  . . 134 1521 100.00 . . . . 0.1348 . . . . . . . . . . . 0.1640 
'X-RAY DIFFRACTION' 2.39 2.74  . . 140 1520 100.00 . . . . 0.1366 . . . . . . . . . . . 0.1642 
'X-RAY DIFFRACTION' 2.74 3.45  . . 137 1548 100.00 . . . . 0.1377 . . . . . . . . . . . 0.1980 
'X-RAY DIFFRACTION' 3.45 34.27 . . 150 1639 99.94  . . . . 0.1429 . . . . . . . . . . . 0.1786 
# 
_struct.entry_id                     9FC6 
_struct.title                        'HEN EGG-WHITE Lysozyme incubated at 87% relative humidity' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FC6 
_struct_keywords.text            'Hydrolase, relative humidity' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LYSC_CHICK 
_struct_ref.pdbx_db_accession          P00698 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_struct_ref.pdbx_align_begin           19 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FC6 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 129 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P00698 
_struct_ref_seq.db_align_beg                  19 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  147 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       129 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 710  ? 
1 MORE         -36  ? 
1 'SSA (A^2)'  6560 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLY A 4   ? HIS A 15  ? GLY A 4   HIS A 15  1 ? 12 
HELX_P HELX_P2 AA2 ASN A 19  ? TYR A 23  ? ASN A 19  TYR A 23  5 ? 5  
HELX_P HELX_P3 AA3 SER A 24  ? ASN A 37  ? SER A 24  ASN A 37  1 ? 14 
HELX_P HELX_P4 AA4 PRO A 79  ? SER A 85  ? PRO A 79  SER A 85  5 ? 7  
HELX_P HELX_P5 AA5 ILE A 88  ? SER A 100 ? ILE A 88  SER A 100 1 ? 13 
HELX_P HELX_P6 AA6 ASN A 103 ? ALA A 107 ? ASN A 103 ALA A 107 5 ? 5  
HELX_P HELX_P7 AA7 TRP A 108 ? CYS A 115 ? TRP A 108 CYS A 115 1 ? 8  
HELX_P HELX_P8 AA8 ASP A 119 ? ARG A 125 ? ASP A 119 ARG A 125 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 6  SG ? ? ? 1_555 A CYS 127 SG ? ? A CYS 6   A CYS 127 1_555 ? ? ? ? ? ? ? 1.998 ? ? 
disulf2 disulf ? ? A CYS 30 SG ? ? ? 1_555 A CYS 115 SG ? ? A CYS 30  A CYS 115 1_555 ? ? ? ? ? ? ? 2.043 ? ? 
disulf3 disulf ? ? A CYS 64 SG ? ? ? 1_555 A CYS 80  SG ? ? A CYS 64  A CYS 80  1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf4 disulf ? ? A CYS 76 SG ? ? ? 1_555 A CYS 94  SG ? ? A CYS 76  A CYS 94  1_555 ? ? ? ? ? ? ? 2.043 ? ? 
metalc1 metalc ? ? A SER 24 OG ? ? ? 1_555 F NA  .   NA ? ? A SER 24  A NA  205 1_555 ? ? ? ? ? ? ? 2.926 ? ? 
metalc2 metalc ? ? A SER 60 O  ? ? ? 1_555 E NA  .   NA ? ? A SER 60  A NA  204 1_555 ? ? ? ? ? ? ? 2.278 ? ? 
metalc3 metalc ? ? A CYS 64 O  ? ? ? 1_555 E NA  .   NA ? ? A CYS 64  A NA  204 1_555 ? ? ? ? ? ? ? 2.447 ? ? 
metalc4 metalc ? ? A SER 72 OG A ? ? 1_555 E NA  .   NA ? ? A SER 72  A NA  204 1_555 ? ? ? ? ? ? ? 2.363 ? ? 
metalc5 metalc ? ? A SER 72 OG B ? ? 1_555 E NA  .   NA ? ? A SER 72  A NA  204 1_555 ? ? ? ? ? ? ? 2.263 ? ? 
metalc6 metalc ? ? A ARG 73 O  A ? ? 1_555 E NA  .   NA ? ? A ARG 73  A NA  204 1_555 ? ? ? ? ? ? ? 2.415 ? ? 
metalc7 metalc ? ? E NA  .  NA ? ? ? 1_555 G HOH .   O  ? ? A NA  204 A HOH 347 1_555 ? ? ? ? ? ? ? 2.378 ? ? 
metalc8 metalc ? ? E NA  .  NA ? ? ? 1_555 G HOH .   O  ? ? A NA  204 A HOH 355 1_555 ? ? ? ? ? ? ? 2.542 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? A CYS 64 ? A CYS 64  ? 1_555 85.3  ? 
2  O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 OG A A SER 72 ? A SER 72  ? 1_555 88.9  ? 
3  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 OG A A SER 72 ? A SER 72  ? 1_555 162.3 ? 
4  O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 OG B A SER 72 ? A SER 72  ? 1_555 97.0  ? 
5  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 OG B A SER 72 ? A SER 72  ? 1_555 166.3 ? 
6  OG A A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 OG B A SER 72 ? A SER 72  ? 1_555 8.7   ? 
7  O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 98.4  ? 
8  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 95.0  ? 
9  OG A A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 102.4 ? 
10 OG B A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 98.0  ? 
11 O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 347 ? 1_555 170.4 ? 
12 O  ? A CYS 64 ? A CYS 64  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 347 ? 1_555 99.9  ? 
13 OG A A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 347 ? 1_555 83.8  ? 
14 OG B A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 347 ? 1_555 76.1  ? 
15 O  A A ARG 73 ? A ARG 73  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 347 ? 1_555 89.3  ? 
16 O  ? A SER 60 ? A SER 60  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 95.7  ? 
17 O  ? A CYS 64 ? A CYS 64  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 83.2  ? 
18 OG A A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 80.7  ? 
19 OG B A SER 72 ? A SER 72  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 83.1  ? 
20 O  A A ARG 73 ? A ARG 73  ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 165.6 ? 
21 O  ? G HOH .  ? A HOH 347 ? 1_555 NA ? E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 355 ? 1_555 77.0  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 6  ? CYS A 127 ? CYS A 6  ? 1_555 CYS A 127 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 30 ? CYS A 115 ? CYS A 30 ? 1_555 CYS A 115 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 64 ? CYS A 80  ? CYS A 64 ? 1_555 CYS A 80  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 76 ? CYS A 94  ? CYS A 76 ? 1_555 CYS A 94  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 43 ? ARG A 45 ? THR A 43 ARG A 45 
AA1 2 THR A 51 ? TYR A 53 ? THR A 51 TYR A 53 
AA1 3 ILE A 58 ? ASN A 59 ? ILE A 58 ASN A 59 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN A 44 ? N ASN A 44 O ASP A 52 ? O ASP A 52 
AA1 2 3 N TYR A 53 ? N TYR A 53 O ILE A 58 ? O ILE A 58 
# 
_pdbx_entry_details.entry_id                   9FC6 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TRP A 62 ? B -134.42 -31.48 
2 1 ARG A 68 ? B -142.36 26.11  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 348 ? G HOH . 
2 1 A HOH 376 ? G HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
EDO C1   C  N N 89  
EDO O1   O  N N 90  
EDO C2   C  N N 91  
EDO O2   O  N N 92  
EDO H11  H  N N 93  
EDO H12  H  N N 94  
EDO HO1  H  N N 95  
EDO H21  H  N N 96  
EDO H22  H  N N 97  
EDO HO2  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MET N    N  N N 241 
MET CA   C  N S 242 
MET C    C  N N 243 
MET O    O  N N 244 
MET CB   C  N N 245 
MET CG   C  N N 246 
MET SD   S  N N 247 
MET CE   C  N N 248 
MET OXT  O  N N 249 
MET H    H  N N 250 
MET H2   H  N N 251 
MET HA   H  N N 252 
MET HB2  H  N N 253 
MET HB3  H  N N 254 
MET HG2  H  N N 255 
MET HG3  H  N N 256 
MET HE1  H  N N 257 
MET HE2  H  N N 258 
MET HE3  H  N N 259 
MET HXT  H  N N 260 
NA  NA   NA N N 261 
PHE N    N  N N 262 
PHE CA   C  N S 263 
PHE C    C  N N 264 
PHE O    O  N N 265 
PHE CB   C  N N 266 
PHE CG   C  Y N 267 
PHE CD1  C  Y N 268 
PHE CD2  C  Y N 269 
PHE CE1  C  Y N 270 
PHE CE2  C  Y N 271 
PHE CZ   C  Y N 272 
PHE OXT  O  N N 273 
PHE H    H  N N 274 
PHE H2   H  N N 275 
PHE HA   H  N N 276 
PHE HB2  H  N N 277 
PHE HB3  H  N N 278 
PHE HD1  H  N N 279 
PHE HD2  H  N N 280 
PHE HE1  H  N N 281 
PHE HE2  H  N N 282 
PHE HZ   H  N N 283 
PHE HXT  H  N N 284 
PRO N    N  N N 285 
PRO CA   C  N S 286 
PRO C    C  N N 287 
PRO O    O  N N 288 
PRO CB   C  N N 289 
PRO CG   C  N N 290 
PRO CD   C  N N 291 
PRO OXT  O  N N 292 
PRO H    H  N N 293 
PRO HA   H  N N 294 
PRO HB2  H  N N 295 
PRO HB3  H  N N 296 
PRO HG2  H  N N 297 
PRO HG3  H  N N 298 
PRO HD2  H  N N 299 
PRO HD3  H  N N 300 
PRO HXT  H  N N 301 
SER N    N  N N 302 
SER CA   C  N S 303 
SER C    C  N N 304 
SER O    O  N N 305 
SER CB   C  N N 306 
SER OG   O  N N 307 
SER OXT  O  N N 308 
SER H    H  N N 309 
SER H2   H  N N 310 
SER HA   H  N N 311 
SER HB2  H  N N 312 
SER HB3  H  N N 313 
SER HG   H  N N 314 
SER HXT  H  N N 315 
THR N    N  N N 316 
THR CA   C  N S 317 
THR C    C  N N 318 
THR O    O  N N 319 
THR CB   C  N R 320 
THR OG1  O  N N 321 
THR CG2  C  N N 322 
THR OXT  O  N N 323 
THR H    H  N N 324 
THR H2   H  N N 325 
THR HA   H  N N 326 
THR HB   H  N N 327 
THR HG1  H  N N 328 
THR HG21 H  N N 329 
THR HG22 H  N N 330 
THR HG23 H  N N 331 
THR HXT  H  N N 332 
TRP N    N  N N 333 
TRP CA   C  N S 334 
TRP C    C  N N 335 
TRP O    O  N N 336 
TRP CB   C  N N 337 
TRP CG   C  Y N 338 
TRP CD1  C  Y N 339 
TRP CD2  C  Y N 340 
TRP NE1  N  Y N 341 
TRP CE2  C  Y N 342 
TRP CE3  C  Y N 343 
TRP CZ2  C  Y N 344 
TRP CZ3  C  Y N 345 
TRP CH2  C  Y N 346 
TRP OXT  O  N N 347 
TRP H    H  N N 348 
TRP H2   H  N N 349 
TRP HA   H  N N 350 
TRP HB2  H  N N 351 
TRP HB3  H  N N 352 
TRP HD1  H  N N 353 
TRP HE1  H  N N 354 
TRP HE3  H  N N 355 
TRP HZ2  H  N N 356 
TRP HZ3  H  N N 357 
TRP HH2  H  N N 358 
TRP HXT  H  N N 359 
TYR N    N  N N 360 
TYR CA   C  N S 361 
TYR C    C  N N 362 
TYR O    O  N N 363 
TYR CB   C  N N 364 
TYR CG   C  Y N 365 
TYR CD1  C  Y N 366 
TYR CD2  C  Y N 367 
TYR CE1  C  Y N 368 
TYR CE2  C  Y N 369 
TYR CZ   C  Y N 370 
TYR OH   O  N N 371 
TYR OXT  O  N N 372 
TYR H    H  N N 373 
TYR H2   H  N N 374 
TYR HA   H  N N 375 
TYR HB2  H  N N 376 
TYR HB3  H  N N 377 
TYR HD1  H  N N 378 
TYR HD2  H  N N 379 
TYR HE1  H  N N 380 
TYR HE2  H  N N 381 
TYR HH   H  N N 382 
TYR HXT  H  N N 383 
VAL N    N  N N 384 
VAL CA   C  N S 385 
VAL C    C  N N 386 
VAL O    O  N N 387 
VAL CB   C  N N 388 
VAL CG1  C  N N 389 
VAL CG2  C  N N 390 
VAL OXT  O  N N 391 
VAL H    H  N N 392 
VAL H2   H  N N 393 
VAL HA   H  N N 394 
VAL HB   H  N N 395 
VAL HG11 H  N N 396 
VAL HG12 H  N N 397 
VAL HG13 H  N N 398 
VAL HG21 H  N N 399 
VAL HG22 H  N N 400 
VAL HG23 H  N N 401 
VAL HXT  H  N N 402 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
THR N   CA   sing N N 299 
THR N   H    sing N N 300 
THR N   H2   sing N N 301 
THR CA  C    sing N N 302 
THR CA  CB   sing N N 303 
THR CA  HA   sing N N 304 
THR C   O    doub N N 305 
THR C   OXT  sing N N 306 
THR CB  OG1  sing N N 307 
THR CB  CG2  sing N N 308 
THR CB  HB   sing N N 309 
THR OG1 HG1  sing N N 310 
THR CG2 HG21 sing N N 311 
THR CG2 HG22 sing N N 312 
THR CG2 HG23 sing N N 313 
THR OXT HXT  sing N N 314 
TRP N   CA   sing N N 315 
TRP N   H    sing N N 316 
TRP N   H2   sing N N 317 
TRP CA  C    sing N N 318 
TRP CA  CB   sing N N 319 
TRP CA  HA   sing N N 320 
TRP C   O    doub N N 321 
TRP C   OXT  sing N N 322 
TRP CB  CG   sing N N 323 
TRP CB  HB2  sing N N 324 
TRP CB  HB3  sing N N 325 
TRP CG  CD1  doub Y N 326 
TRP CG  CD2  sing Y N 327 
TRP CD1 NE1  sing Y N 328 
TRP CD1 HD1  sing N N 329 
TRP CD2 CE2  doub Y N 330 
TRP CD2 CE3  sing Y N 331 
TRP NE1 CE2  sing Y N 332 
TRP NE1 HE1  sing N N 333 
TRP CE2 CZ2  sing Y N 334 
TRP CE3 CZ3  doub Y N 335 
TRP CE3 HE3  sing N N 336 
TRP CZ2 CH2  doub Y N 337 
TRP CZ2 HZ2  sing N N 338 
TRP CZ3 CH2  sing Y N 339 
TRP CZ3 HZ3  sing N N 340 
TRP CH2 HH2  sing N N 341 
TRP OXT HXT  sing N N 342 
TYR N   CA   sing N N 343 
TYR N   H    sing N N 344 
TYR N   H2   sing N N 345 
TYR CA  C    sing N N 346 
TYR CA  CB   sing N N 347 
TYR CA  HA   sing N N 348 
TYR C   O    doub N N 349 
TYR C   OXT  sing N N 350 
TYR CB  CG   sing N N 351 
TYR CB  HB2  sing N N 352 
TYR CB  HB3  sing N N 353 
TYR CG  CD1  doub Y N 354 
TYR CG  CD2  sing Y N 355 
TYR CD1 CE1  sing Y N 356 
TYR CD1 HD1  sing N N 357 
TYR CD2 CE2  doub Y N 358 
TYR CD2 HD2  sing N N 359 
TYR CE1 CZ   doub Y N 360 
TYR CE1 HE1  sing N N 361 
TYR CE2 CZ   sing Y N 362 
TYR CE2 HE2  sing N N 363 
TYR CZ  OH   sing N N 364 
TYR OH  HH   sing N N 365 
TYR OXT HXT  sing N N 366 
VAL N   CA   sing N N 367 
VAL N   H    sing N N 368 
VAL N   H2   sing N N 369 
VAL CA  C    sing N N 370 
VAL CA  CB   sing N N 371 
VAL CA  HA   sing N N 372 
VAL C   O    doub N N 373 
VAL C   OXT  sing N N 374 
VAL CB  CG1  sing N N 375 
VAL CB  CG2  sing N N 376 
VAL CB  HB   sing N N 377 
VAL CG1 HG11 sing N N 378 
VAL CG1 HG12 sing N N 379 
VAL CG1 HG13 sing N N 380 
VAL CG2 HG21 sing N N 381 
VAL CG2 HG22 sing N N 382 
VAL CG2 HG23 sing N N 383 
VAL OXT HXT  sing N N 384 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Helmholtz Association' Germany FISCOV 1 
'Helmholtz Association' Germany FRAGX  2 
'Helmholtz Association' Germany HIR3X  3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'intern model of RT lysozyme' 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FC6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012578 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012578 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.026327 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
NA ? ? 9.38062 1.54875 ? ? 3.38349  72.32734 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    A LYS A 1 1   ? -3.28977  -10.26369 -8.60951  0.481 22.16557 ? 1   LYS A N    1 
ATOM   2    N  N    B LYS A 1 1   ? -3.32926  -10.18302 -8.78744  0.519 23.35109 ? 1   LYS A N    1 
ATOM   3    C  CA   A LYS A 1 1   ? -2.44446  -10.60389 -9.78618  0.481 24.62321 ? 1   LYS A CA   1 
ATOM   4    C  CA   B LYS A 1 1   ? -2.40248  -10.54217 -9.89149  0.519 24.56475 ? 1   LYS A CA   1 
ATOM   5    C  C    A LYS A 1 1   ? -2.54817  -12.09701 -10.04080 0.481 23.24367 ? 1   LYS A C    1 
ATOM   6    C  C    B LYS A 1 1   ? -2.42597  -12.04395 -10.05373 0.519 23.08531 ? 1   LYS A C    1 
ATOM   7    O  O    A LYS A 1 1   ? -2.67668  -12.89206 -9.10388  0.481 20.96928 ? 1   LYS A O    1 
ATOM   8    O  O    B LYS A 1 1   ? -2.35562  -12.77111 -9.04978  0.519 22.27152 ? 1   LYS A O    1 
ATOM   9    C  CB   A LYS A 1 1   ? -1.00497  -10.19986 -9.48778  0.481 26.04094 ? 1   LYS A CB   1 
ATOM   10   C  CB   B LYS A 1 1   ? -0.99689  -10.07167 -9.53675  0.519 26.18445 ? 1   LYS A CB   1 
ATOM   11   C  CG   A LYS A 1 1   ? 0.00932   -10.55545 -10.55461 0.481 29.67377 ? 1   LYS A CG   1 
ATOM   12   C  CG   B LYS A 1 1   ? 0.10678   -10.61635 -10.42628 0.519 29.75167 ? 1   LYS A CG   1 
ATOM   13   C  CD   A LYS A 1 1   ? 1.38414   -10.13699 -10.08627 0.481 29.51496 ? 1   LYS A CD   1 
ATOM   14   C  CD   B LYS A 1 1   ? 1.43026   -9.96641  -10.07319 0.519 29.18790 ? 1   LYS A CD   1 
ATOM   15   C  CE   A LYS A 1 1   ? 2.46075   -10.74806 -10.94846 0.481 30.60798 ? 1   LYS A CE   1 
ATOM   16   C  CE   B LYS A 1 1   ? 2.56538   -10.59276 -10.85192 0.519 30.54149 ? 1   LYS A CE   1 
ATOM   17   N  NZ   A LYS A 1 1   ? 3.70905   -9.95292  -10.86450 0.481 33.46765 ? 1   LYS A NZ   1 
ATOM   18   N  NZ   B LYS A 1 1   ? 2.39247   -10.38943 -12.30996 0.519 32.15236 ? 1   LYS A NZ   1 
ATOM   19   H  H1   A LYS A 1 1   ? -4.10268  -10.60927 -8.71838  0.481 26.59932 ? 1   LYS A H1   1 
ATOM   20   H  H1   B LYS A 1 1   ? -3.77481  -10.90792 -8.52648  0.519 28.02195 ? 1   LYS A H1   1 
ATOM   21   H  H2   A LYS A 1 1   ? -2.92098  -10.59935 -7.87234  0.481 26.59932 ? 1   LYS A H2   1 
ATOM   22   H  H2   B LYS A 1 1   ? -2.86289  -9.85876  -8.10228  0.519 28.02195 ? 1   LYS A H2   1 
ATOM   23   H  H3   A LYS A 1 1   ? -3.35113  -9.37901  -8.53418  0.481 26.59932 ? 1   LYS A H3   1 
ATOM   24   H  H3   B LYS A 1 1   ? -3.90530  -9.56721  -9.07216  0.519 28.02195 ? 1   LYS A H3   1 
ATOM   25   H  HA   A LYS A 1 1   ? -2.72698  -10.13360 -10.58613 0.481 29.54850 ? 1   LYS A HA   1 
ATOM   26   H  HA   B LYS A 1 1   ? -2.65687  -10.12180 -10.72783 0.519 29.47834 ? 1   LYS A HA   1 
ATOM   27   H  HB2  A LYS A 1 1   ? -0.97650  -9.23716  -9.37250  0.481 31.24976 ? 1   LYS A HB2  1 
ATOM   28   H  HB2  B LYS A 1 1   ? -0.97168  -9.10417  -9.60168  0.519 31.42198 ? 1   LYS A HB2  1 
ATOM   29   H  HB3  A LYS A 1 1   ? -0.72849  -10.64036 -8.66899  0.481 31.24976 ? 1   LYS A HB3  1 
ATOM   30   H  HB3  B LYS A 1 1   ? -0.80093  -10.34840 -8.62795  0.519 31.42198 ? 1   LYS A HB3  1 
ATOM   31   H  HG2  A LYS A 1 1   ? 0.00641   -11.51332 -10.70752 0.481 35.60916 ? 1   LYS A HG2  1 
ATOM   32   H  HG2  B LYS A 1 1   ? 0.18708   -11.57439 -10.29737 0.519 35.70264 ? 1   LYS A HG2  1 
ATOM   33   H  HG3  A LYS A 1 1   ? -0.19913  -10.08738 -11.37823 0.481 35.60916 ? 1   LYS A HG3  1 
ATOM   34   H  HG3  B LYS A 1 1   ? -0.09656  -10.42241 -11.35468 0.519 35.70264 ? 1   LYS A HG3  1 
ATOM   35   H  HD2  A LYS A 1 1   ? 1.46232   -9.17146  -10.13655 0.481 35.41859 ? 1   LYS A HD2  1 
ATOM   36   H  HD2  B LYS A 1 1   ? 1.39427   -9.02146  -10.28924 0.519 35.02612 ? 1   LYS A HD2  1 
ATOM   37   H  HD3  A LYS A 1 1   ? 1.51805   -10.43354 -9.17247  0.481 35.41859 ? 1   LYS A HD3  1 
ATOM   38   H  HD3  B LYS A 1 1   ? 1.60577   -10.08383 -9.12646  0.519 35.02612 ? 1   LYS A HD3  1 
ATOM   39   H  HE2  A LYS A 1 1   ? 2.64777   -11.64982 -10.64391 0.481 36.73021 ? 1   LYS A HE2  1 
ATOM   40   H  HE2  B LYS A 1 1   ? 3.40369   -10.18537 -10.58327 0.519 36.65042 ? 1   LYS A HE2  1 
ATOM   41   H  HE3  A LYS A 1 1   ? 2.16639   -10.76435 -11.87258 0.481 36.73021 ? 1   LYS A HE3  1 
ATOM   42   H  HE3  B LYS A 1 1   ? 2.58874   -11.54647 -10.67643 0.519 36.65042 ? 1   LYS A HE3  1 
ATOM   43   H  HZ1  A LYS A 1 1   ? 4.37552   -10.38988 -11.26072 0.481 40.16182 ? 1   LYS A HZ1  1 
ATOM   44   H  HZ1  B LYS A 1 1   ? 2.34738   -9.51957  -12.49277 0.519 38.58347 ? 1   LYS A HZ1  1 
ATOM   45   H  HZ2  A LYS A 1 1   ? 3.59769   -9.16790  -11.26877 0.481 40.16182 ? 1   LYS A HZ2  1 
ATOM   46   H  HZ2  B LYS A 1 1   ? 3.08103   -10.74178 -12.75022 0.519 38.58347 ? 1   LYS A HZ2  1 
ATOM   47   H  HZ3  A LYS A 1 1   ? 3.92293   -9.81117  -10.01229 0.481 40.16182 ? 1   LYS A HZ3  1 
ATOM   48   H  HZ3  B LYS A 1 1   ? 1.64245   -10.78166 -12.58517 0.519 38.58347 ? 1   LYS A HZ3  1 
ATOM   49   N  N    . VAL A 1 2   ? -2.54508  -12.50154 -11.29961 1.000 23.56401 ? 2   VAL A N    1 
ATOM   50   C  CA   . VAL A 1 2   ? -2.46709  -13.91347 -11.64957 1.000 23.12450 ? 2   VAL A CA   1 
ATOM   51   C  C    . VAL A 1 2   ? -1.05652  -14.15178 -12.15365 1.000 25.05887 ? 2   VAL A C    1 
ATOM   52   O  O    . VAL A 1 2   ? -0.62425  -13.55297 -13.14691 1.000 26.89764 ? 2   VAL A O    1 
ATOM   53   C  CB   . VAL A 1 2   ? -3.53517  -14.31757 -12.67125 1.000 22.37787 ? 2   VAL A CB   1 
ATOM   54   C  CG1  . VAL A 1 2   ? -3.40555  -15.78697 -13.02607 1.000 28.17810 ? 2   VAL A CG1  1 
ATOM   55   C  CG2  . VAL A 1 2   ? -4.92490  -14.04218 -12.11868 1.000 24.27582 ? 2   VAL A CG2  1 
ATOM   56   H  H    . VAL A 1 2   ? -2.67611  -11.99743 -11.98394 1.000 28.27746 ? 2   VAL A H    1 
ATOM   57   H  HA   . VAL A 1 2   ? -2.61036  -14.46217 -10.86262 1.000 27.75004 ? 2   VAL A HA   1 
ATOM   58   H  HB   . VAL A 1 2   ? -3.40778  -13.79255 -13.47687 1.000 26.85408 ? 2   VAL A HB   1 
ATOM   59   H  HG11 . VAL A 1 2   ? -4.15078  -16.04208 -13.59216 1.000 33.81436 ? 2   VAL A HG11 1 
ATOM   60   H  HG12 . VAL A 1 2   ? -2.56933  -15.92537 -13.49775 1.000 33.81436 ? 2   VAL A HG12 1 
ATOM   61   H  HG13 . VAL A 1 2   ? -3.41561  -16.31101 -12.20988 1.000 33.81436 ? 2   VAL A HG13 1 
ATOM   62   H  HG21 . VAL A 1 2   ? -5.58174  -14.23286 -12.80651 1.000 29.13163 ? 2   VAL A HG21 1 
ATOM   63   H  HG22 . VAL A 1 2   ? -5.07726  -14.61212 -11.34872 1.000 29.13163 ? 2   VAL A HG22 1 
ATOM   64   H  HG23 . VAL A 1 2   ? -4.98152  -13.10998 -11.85657 1.000 29.13163 ? 2   VAL A HG23 1 
ATOM   65   N  N    . PHE A 1 3   ? -0.28404  -14.94209 -11.42626 1.000 20.40816 ? 3   PHE A N    1 
ATOM   66   C  CA   . PHE A 1 3   ? 1.09379   -15.20213 -11.80707 1.000 21.49524 ? 3   PHE A CA   1 
ATOM   67   C  C    . PHE A 1 3   ? 1.15914   -16.26867 -12.87982 1.000 25.23465 ? 3   PHE A C    1 
ATOM   68   O  O    . PHE A 1 3   ? 0.31511   -17.15269 -12.96061 1.000 23.32192 ? 3   PHE A O    1 
ATOM   69   C  CB   . PHE A 1 3   ? 1.87669   -15.73208 -10.60162 1.000 23.00509 ? 3   PHE A CB   1 
ATOM   70   C  CG   . PHE A 1 3   ? 2.43238   -14.67353 -9.67989  1.000 20.72616 ? 3   PHE A CG   1 
ATOM   71   C  CD1  . PHE A 1 3   ? 1.63813   -14.09882 -8.68731  1.000 25.14479 ? 3   PHE A CD1  1 
ATOM   72   C  CD2  . PHE A 1 3   ? 3.75072   -14.29150 -9.75478  1.000 24.91598 ? 3   PHE A CD2  1 
ATOM   73   C  CE1  . PHE A 1 3   ? 2.15280   -13.17796 -7.83732  1.000 25.47306 ? 3   PHE A CE1  1 
ATOM   74   C  CE2  . PHE A 1 3   ? 4.26211   -13.35812 -8.90892  1.000 27.14086 ? 3   PHE A CE2  1 
ATOM   75   C  CZ   . PHE A 1 3   ? 3.46425   -12.78987 -7.94137  1.000 30.36733 ? 3   PHE A CZ   1 
ATOM   76   H  H    . PHE A 1 3   ? -0.53396  -15.34073 -10.70638 1.000 24.49044 ? 3   PHE A H    1 
ATOM   77   H  HA   . PHE A 1 3   ? 1.48887   -14.37882 -12.13413 1.000 25.79493 ? 3   PHE A HA   1 
ATOM   78   H  HB2  . PHE A 1 3   ? 1.28587   -16.29335 -10.07550 1.000 27.60675 ? 3   PHE A HB2  1 
ATOM   79   H  HB3  . PHE A 1 3   ? 2.62605   -16.25404 -10.92861 1.000 27.60675 ? 3   PHE A HB3  1 
ATOM   80   H  HD1  . PHE A 1 3   ? 0.74630   -14.35041 -8.60833  1.000 30.17439 ? 3   PHE A HD1  1 
ATOM   81   H  HD2  . PHE A 1 3   ? 4.30265   -14.67845 -10.39552 1.000 29.89982 ? 3   PHE A HD2  1 
ATOM   82   H  HE1  . PHE A 1 3   ? 1.61258   -12.80597 -7.17800  1.000 30.56832 ? 3   PHE A HE1  1 
ATOM   83   H  HE2  . PHE A 1 3   ? 5.15321   -13.10277 -8.98402  1.000 32.56968 ? 3   PHE A HE2  1 
ATOM   84   H  HZ   . PHE A 1 3   ? 3.81128   -12.14889 -7.36376  1.000 36.44144 ? 3   PHE A HZ   1 
ATOM   85   N  N    . GLY A 1 4   ? 2.19961   -16.17910 -13.71435 1.000 25.38637 ? 4   GLY A N    1 
ATOM   86   C  CA   . GLY A 1 4   ? 2.61723   -17.33522 -14.45879 1.000 24.75158 ? 4   GLY A CA   1 
ATOM   87   C  C    . GLY A 1 4   ? 3.41562   -18.28050 -13.58792 1.000 21.43512 ? 4   GLY A C    1 
ATOM   88   O  O    . GLY A 1 4   ? 3.99296   -17.88992 -12.57975 1.000 23.81543 ? 4   GLY A O    1 
ATOM   89   H  H    . GLY A 1 4   ? 2.66246   -15.46805 -13.85503 1.000 30.46428 ? 4   GLY A H    1 
ATOM   90   H  HA2  . GLY A 1 4   ? 1.83859   -17.80487 -14.79649 1.000 29.70254 ? 4   GLY A HA2  1 
ATOM   91   H  HA3  . GLY A 1 4   ? 3.16911   -17.05967 -15.20739 1.000 29.70254 ? 4   GLY A HA3  1 
ATOM   92   N  N    . ARG A 1 5   ? 3.45771   -19.53769 -14.01843 1.000 25.97934 ? 5   ARG A N    1 
ATOM   93   C  CA   . ARG A 1 5   ? 4.14414   -20.58742 -13.28047 1.000 24.71764 ? 5   ARG A CA   1 
ATOM   94   C  C    . ARG A 1 5   ? 5.60103   -20.23385 -12.98702 1.000 23.44290 ? 5   ARG A C    1 
ATOM   95   O  O    . ARG A 1 5   ? 6.06140   -20.27096 -11.83366 1.000 22.94126 ? 5   ARG A O    1 
ATOM   96   C  CB   . ARG A 1 5   ? 4.01614   -21.85700 -14.13240 1.000 30.88800 ? 5   ARG A CB   1 
ATOM   97   C  CG   . ARG A 1 5   ? 4.75446   -23.03162 -13.63568 1.000 30.51518 ? 5   ARG A CG   1 
ATOM   98   C  CD   . ARG A 1 5   ? 4.48156   -24.24453 -14.52807 1.000 26.24481 ? 5   ARG A CD   1 
ATOM   99   N  NE   . ARG A 1 5   ? 5.08148   -24.16744 -15.85405 1.000 33.49636 ? 5   ARG A NE   1 
ATOM   100  C  CZ   . ARG A 1 5   ? 6.31210   -24.57411 -16.13621 1.000 34.23002 ? 5   ARG A CZ   1 
ATOM   101  N  NH1  . ARG A 1 5   ? 7.12527   -25.01217 -15.18888 1.000 30.21499 ? 5   ARG A NH1  1 
ATOM   102  N  NH2  . ARG A 1 5   ? 6.74190   -24.52646 -17.39882 1.000 37.70262 ? 5   ARG A NH2  1 
ATOM   103  H  H    . ARG A 1 5   ? 3.09071   -19.81197 -14.74622 1.000 31.17585 ? 5   ARG A H    1 
ATOM   104  H  HA   . ARG A 1 5   ? 3.73890   -20.72454 -12.40990 1.000 29.66181 ? 5   ARG A HA   1 
ATOM   105  H  HB2  . ARG A 1 5   ? 3.07864   -22.10228 -14.17528 1.000 37.06623 ? 5   ARG A HB2  1 
ATOM   106  H  HB3  . ARG A 1 5   ? 4.34908   -21.66195 -15.02235 1.000 37.06623 ? 5   ARG A HB3  1 
ATOM   107  H  HG2  . ARG A 1 5   ? 5.70662   -22.84673 -13.64624 1.000 36.61886 ? 5   ARG A HG2  1 
ATOM   108  H  HG3  . ARG A 1 5   ? 4.46691   -23.23975 -12.73296 1.000 36.61886 ? 5   ARG A HG3  1 
ATOM   109  H  HD2  . ARG A 1 5   ? 4.83629   -25.03528 -14.09244 1.000 31.49441 ? 5   ARG A HD2  1 
ATOM   110  H  HD3  . ARG A 1 5   ? 3.52278   -24.33257 -14.64586 1.000 31.49441 ? 5   ARG A HD3  1 
ATOM   111  H  HE   . ARG A 1 5   ? 4.60873   -23.83818 -16.49255 1.000 40.19627 ? 5   ARG A HE   1 
ATOM   112  H  HH11 . ARG A 1 5   ? 6.85916   -25.03721 -14.37147 1.000 36.25862 ? 5   ARG A HH11 1 
ATOM   113  H  HH12 . ARG A 1 5   ? 7.91994   -25.27186 -15.39053 1.000 36.25862 ? 5   ARG A HH12 1 
ATOM   114  H  HH21 . ARG A 1 5   ? 6.22267   -24.23442 -18.01907 1.000 45.24378 ? 5   ARG A HH21 1 
ATOM   115  H  HH22 . ARG A 1 5   ? 7.53808   -24.78781 -17.59218 1.000 45.24378 ? 5   ARG A HH22 1 
ATOM   116  N  N    . CYS A 1 6   ? 6.37974   -19.92490 -14.03930 1.000 24.97030 ? 6   CYS A N    1 
ATOM   117  C  CA   . CYS A 1 6   ? 7.78804   -19.63122 -13.80738 1.000 25.95897 ? 6   CYS A CA   1 
ATOM   118  C  C    . CYS A 1 6   ? 7.99630   -18.30075 -13.09493 1.000 22.58005 ? 6   CYS A C    1 
ATOM   119  O  O    . CYS A 1 6   ? 8.94094   -18.15591 -12.32195 1.000 24.17642 ? 6   CYS A O    1 
ATOM   120  C  CB   . CYS A 1 6   ? 8.56503   -19.66612 -15.13343 1.000 26.14409 ? 6   CYS A CB   1 
ATOM   121  S  SG   . CYS A 1 6   ? 8.64590   -21.30950 -15.88844 1.000 28.55375 ? 6   CYS A SG   1 
ATOM   122  H  H    . CYS A 1 6   ? 6.12100   -19.88247 -14.85835 1.000 29.96500 ? 6   CYS A H    1 
ATOM   123  H  HA   . CYS A 1 6   ? 8.15023   -20.32320 -13.23215 1.000 31.15140 ? 6   CYS A HA   1 
ATOM   124  H  HB2  . CYS A 1 6   ? 8.13103   -19.07114 -15.76473 1.000 31.37355 ? 6   CYS A HB2  1 
ATOM   125  H  HB3  . CYS A 1 6   ? 9.47420   -19.37024 -14.96985 1.000 31.37355 ? 6   CYS A HB3  1 
ATOM   126  N  N    . GLU A 1 7   ? 7.13715   -17.31705 -13.34123 1.000 23.15664 ? 7   GLU A N    1 
ATOM   127  C  CA   . GLU A 1 7   ? 7.23688   -16.06018 -12.62562 1.000 23.75316 ? 7   GLU A CA   1 
ATOM   128  C  C    . GLU A 1 7   ? 7.05446   -16.27558 -11.13618 1.000 20.06903 ? 7   GLU A C    1 
ATOM   129  O  O    . GLU A 1 7   ? 7.75712   -15.68441 -10.31900 1.000 24.39560 ? 7   GLU A O    1 
ATOM   130  C  CB   . GLU A 1 7   ? 6.15498   -15.12153 -13.14690 1.000 28.56242 ? 7   GLU A CB   1 
ATOM   131  C  CG   . GLU A 1 7   ? 6.13641   -13.76004 -12.53431 1.000 27.71862 ? 7   GLU A CG   1 
ATOM   132  C  CD   . GLU A 1 7   ? 4.92397   -12.94011 -12.95999 1.000 30.61750 ? 7   GLU A CD   1 
ATOM   133  O  OE1  . GLU A 1 7   ? 3.91137   -13.50209 -13.47650 1.000 32.69084 ? 7   GLU A OE1  1 
ATOM   134  O  OE2  . GLU A 1 7   ? 4.99602   -11.70489 -12.75979 1.000 35.35565 ? 7   GLU A OE2  1 
ATOM   135  H  H    . GLU A 1 7   ? 6.49528   -17.35466 -13.91236 1.000 27.78861 ? 7   GLU A H    1 
ATOM   136  H  HA   . GLU A 1 7   ? 8.10964   -15.66345 -12.77321 1.000 28.50443 ? 7   GLU A HA   1 
ATOM   137  H  HB2  . GLU A 1 7   ? 6.28436   -15.00701 -14.10139 1.000 34.27554 ? 7   GLU A HB2  1 
ATOM   138  H  HB3  . GLU A 1 7   ? 5.29066   -15.52712 -12.97557 1.000 34.27554 ? 7   GLU A HB3  1 
ATOM   139  H  HG2  . GLU A 1 7   ? 6.11529   -13.84796 -11.56853 1.000 33.26298 ? 7   GLU A HG2  1 
ATOM   140  H  HG3  . GLU A 1 7   ? 6.93409   -13.27984 -12.80636 1.000 33.26298 ? 7   GLU A HG3  1 
ATOM   141  N  N    . LEU A 1 8   ? 6.08243   -17.11792 -10.75940 1.000 22.24579 ? 8   LEU A N    1 
ATOM   142  C  CA   . LEU A 1 8   ? 5.87888   -17.36724 -9.33282  1.000 21.00617 ? 8   LEU A CA   1 
ATOM   143  C  C    . LEU A 1 8   ? 7.02942   -18.15932 -8.73016  1.000 20.14364 ? 8   LEU A C    1 
ATOM   144  O  O    . LEU A 1 8   ? 7.46243   -17.88623 -7.60177  1.000 20.92914 ? 8   LEU A O    1 
ATOM   145  C  CB   . LEU A 1 8   ? 4.55774   -18.10384 -9.15320  1.000 22.27792 ? 8   LEU A CB   1 
ATOM   146  C  CG   . LEU A 1 8   ? 4.26776   -18.44197 -7.69908  1.000 20.26031 ? 8   LEU A CG   1 
ATOM   147  C  CD1  . LEU A 1 8   ? 4.02916   -17.17405 -6.91523  1.000 25.43658 ? 8   LEU A CD1  1 
ATOM   148  C  CD2  . LEU A 1 8   ? 3.07572   -19.36752 -7.62055  1.000 24.38524 ? 8   LEU A CD2  1 
ATOM   149  H  H    . LEU A 1 8   ? 5.55134   -17.53834 -11.28930 1.000 26.69558 ? 8   LEU A H    1 
ATOM   150  H  HA   . LEU A 1 8   ? 5.83694   -16.52287 -8.85724  1.000 25.20804 ? 8   LEU A HA   1 
ATOM   151  H  HB2  . LEU A 1 8   ? 3.83720   -17.54370 -9.48178  1.000 26.73414 ? 8   LEU A HB2  1 
ATOM   152  H  HB3  . LEU A 1 8   ? 4.58842   -18.93332 -9.65511  1.000 26.73414 ? 8   LEU A HB3  1 
ATOM   153  H  HG   . LEU A 1 8   ? 5.02682   -18.89689 -7.30187  1.000 24.31301 ? 8   LEU A HG   1 
ATOM   154  H  HD11 . LEU A 1 8   ? 3.67963   -17.40473 -6.04029  1.000 30.52454 ? 8   LEU A HD11 1 
ATOM   155  H  HD12 . LEU A 1 8   ? 4.86919   -16.69828 -6.82092  1.000 30.52454 ? 8   LEU A HD12 1 
ATOM   156  H  HD13 . LEU A 1 8   ? 3.38894   -16.62344 -7.39255  1.000 30.52454 ? 8   LEU A HD13 1 
ATOM   157  H  HD21 . LEU A 1 8   ? 2.92771   -19.61392 -6.69411  1.000 29.26293 ? 8   LEU A HD21 1 
ATOM   158  H  HD22 . LEU A 1 8   ? 2.29578   -18.90824 -7.96933  1.000 29.26293 ? 8   LEU A HD22 1 
ATOM   159  H  HD23 . LEU A 1 8   ? 3.25637   -20.16064 -8.14896  1.000 29.26293 ? 8   LEU A HD23 1 
ATOM   160  N  N    . ALA A 1 9   ? 7.53447   -19.15424 -9.45434  1.000 20.58504 ? 9   ALA A N    1 
ATOM   161  C  CA   . ALA A 1 9   ? 8.67844   -19.89807 -8.96483  1.000 21.86001 ? 9   ALA A CA   1 
ATOM   162  C  C    . ALA A 1 9   ? 9.83960   -18.97148 -8.66916  1.000 20.64729 ? 9   ALA A C    1 
ATOM   163  O  O    . ALA A 1 9   ? 10.49746  -19.11296 -7.64388  1.000 23.53194 ? 9   ALA A O    1 
ATOM   164  C  CB   . ALA A 1 9   ? 9.09323   -20.95892 -9.98608  1.000 23.89594 ? 9   ALA A CB   1 
ATOM   165  H  H    . ALA A 1 9   ? 7.23552   -19.41102 -10.21873 1.000 24.70269 ? 9   ALA A H    1 
ATOM   166  H  HA   . ALA A 1 9   ? 8.42762   -20.34929 -8.14361  1.000 26.23266 ? 9   ALA A HA   1 
ATOM   167  H  HB1  . ALA A 1 9   ? 9.87545   -21.42728 -9.65492  1.000 28.67577 ? 9   ALA A HB1  1 
ATOM   168  H  HB2  . ALA A 1 9   ? 8.36091   -21.58320 -10.10810 1.000 28.67577 ? 9   ALA A HB2  1 
ATOM   169  H  HB3  . ALA A 1 9   ? 9.30019   -20.52324 -10.82765 1.000 28.67577 ? 9   ALA A HB3  1 
ATOM   170  N  N    . ALA A 1 10  ? 10.12799  -18.04065 -9.58859  1.000 23.17432 ? 10  ALA A N    1 
ATOM   171  C  CA   . ALA A 1 10  ? 11.23402  -17.12069 -9.37002  1.000 26.05682 ? 10  ALA A CA   1 
ATOM   172  C  C    . ALA A 1 10  ? 10.97724  -16.22668 -8.17084  1.000 22.56231 ? 10  ALA A C    1 
ATOM   173  O  O    . ALA A 1 10  ? 11.89026  -15.94896 -7.38723  1.000 25.13839 ? 10  ALA A O    1 
ATOM   174  C  CB   . ALA A 1 10  ? 11.45009  -16.28318 -10.63314 1.000 26.83651 ? 10  ALA A CB   1 
ATOM   175  H  H    . ALA A 1 10  ? 9.70462   -17.92828 -10.32868 1.000 27.80983 ? 10  ALA A H    1 
ATOM   176  H  HA   . ALA A 1 10  ? 12.04291  -17.62570 -9.19237  1.000 31.26882 ? 10  ALA A HA   1 
ATOM   177  H  HB1  . ALA A 1 10  ? 12.21576  -15.70271 -10.50004 1.000 32.20445 ? 10  ALA A HB1  1 
ATOM   178  H  HB2  . ALA A 1 10  ? 11.61196  -16.87763 -11.38236 1.000 32.20445 ? 10  ALA A HB2  1 
ATOM   179  H  HB3  . ALA A 1 10  ? 10.65628  -15.75088 -10.79874 1.000 32.20445 ? 10  ALA A HB3  1 
ATOM   180  N  N    . ALA A 1 11  ? 9.74354   -15.75165 -8.00626  1.000 22.94369 ? 11  ALA A N    1 
ATOM   181  C  CA   . ALA A 1 11  ? 9.43634   -14.91071 -6.86094  1.000 23.76533 ? 11  ALA A CA   1 
ATOM   182  C  C    . ALA A 1 11  ? 9.57138   -15.68996 -5.56049  1.000 23.65980 ? 11  ALA A C    1 
ATOM   183  O  O    . ALA A 1 11  ? 10.07668  -15.17144 -4.55509  1.000 24.66542 ? 11  ALA A O    1 
ATOM   184  C  CB   . ALA A 1 11  ? 8.02772   -14.34627 -6.99619  1.000 26.95162 ? 11  ALA A CB   1 
ATOM   185  H  H    . ALA A 1 11  ? 9.08138   -15.90018 -8.53455  1.000 27.53307 ? 11  ALA A H    1 
ATOM   186  H  HA   . ALA A 1 11  ? 10.06019  -14.16831 -6.83764  1.000 28.51903 ? 11  ALA A HA   1 
ATOM   187  H  HB1  . ALA A 1 11  ? 7.80131   -13.86460 -6.18524  1.000 32.34258 ? 11  ALA A HB1  1 
ATOM   188  H  HB2  . ALA A 1 11  ? 8.00018   -13.74486 -7.75675  1.000 32.34258 ? 11  ALA A HB2  1 
ATOM   189  H  HB3  . ALA A 1 11  ? 7.40573   -15.07834 -7.13067  1.000 32.34258 ? 11  ALA A HB3  1 
ATOM   190  N  N    . MET A 1 12  ? 9.13664   -16.95422 -5.55506  1.000 22.24989 ? 12  MET A N    1 
ATOM   191  C  CA   . MET A 1 12  ? 9.24658   -17.72020 -4.31574  1.000 22.22136 ? 12  MET A CA   1 
ATOM   192  C  C    . MET A 1 12  ? 10.68851  -18.04547 -3.98529  1.000 21.23109 ? 12  MET A C    1 
ATOM   193  O  O    . MET A 1 12  ? 11.05486  -18.06896 -2.80645  1.000 25.01436 ? 12  MET A O    1 
ATOM   194  C  CB   . MET A 1 12  ? 8.38715   -18.98231 -4.30971  1.000 21.38634 ? 12  MET A CB   1 
ATOM   195  C  CG   . MET A 1 12  ? 6.90159   -18.77838 -4.43521  1.000 20.26699 ? 12  MET A CG   1 
ATOM   196  S  SD   . MET A 1 12  ? 6.03712   -20.35495 -4.70471  1.000 22.60023 ? 12  MET A SD   1 
ATOM   197  C  CE   . MET A 1 12  ? 4.53092   -20.09435 -3.79616  1.000 25.17375 ? 12  MET A CE   1 
ATOM   198  H  H    . MET A 1 12  ? 8.79110   -17.37000 -6.22388  1.000 26.70051 ? 12  MET A H    1 
ATOM   199  H  HA   . MET A 1 12  ? 8.87462   -17.16207 -3.61500  1.000 26.66628 ? 12  MET A HA   1 
ATOM   200  H  HB2  . MET A 1 12  ? 8.66258   -19.53859 -5.05509  1.000 25.66425 ? 12  MET A HB2  1 
ATOM   201  H  HB3  . MET A 1 12  ? 8.54131   -19.44845 -3.47314  1.000 25.66425 ? 12  MET A HB3  1 
ATOM   202  H  HG2  . MET A 1 12  ? 6.56193   -18.37892 -3.61915  1.000 24.32103 ? 12  MET A HG2  1 
ATOM   203  H  HG3  . MET A 1 12  ? 6.71962   -18.19687 -5.18995  1.000 24.32103 ? 12  MET A HG3  1 
ATOM   204  H  HE1  . MET A 1 12  ? 3.97178   -20.88266 -3.87892  1.000 30.20915 ? 12  MET A HE1  1 
ATOM   205  H  HE2  . MET A 1 12  ? 4.74755   -19.93889 -2.86353  1.000 30.20915 ? 12  MET A HE2  1 
ATOM   206  H  HE3  . MET A 1 12  ? 4.07093   -19.32267 -4.16198  1.000 30.20915 ? 12  MET A HE3  1 
ATOM   207  N  N    A LYS A 1 13  ? 11.52333  -18.27032 -5.00310  0.493 24.34003 ? 13  LYS A N    1 
ATOM   208  N  N    B LYS A 1 13  ? 11.51060  -18.28690 -5.01730  0.507 24.33306 ? 13  LYS A N    1 
ATOM   209  C  CA   A LYS A 1 13  ? 12.95446  -18.44251 -4.76851  0.493 26.35036 ? 13  LYS A CA   1 
ATOM   210  C  CA   B LYS A 1 13  ? 12.92843  -18.57446 -4.81653  0.507 26.11072 ? 13  LYS A CA   1 
ATOM   211  C  C    A LYS A 1 13  ? 13.55206  -17.17866 -4.16661  0.493 26.21847 ? 13  LYS A C    1 
ATOM   212  C  C    B LYS A 1 13  ? 13.64114  -17.39140 -4.18574  0.507 26.09378 ? 13  LYS A C    1 
ATOM   213  O  O    A LYS A 1 13  ? 14.26973  -17.22694 -3.16046  0.493 27.06858 ? 13  LYS A O    1 
ATOM   214  O  O    B LYS A 1 13  ? 14.46593  -17.56598 -3.28029  0.507 28.27226 ? 13  LYS A O    1 
ATOM   215  C  CB   A LYS A 1 13  ? 13.64656  -18.77197 -6.09050  0.493 27.79108 ? 13  LYS A CB   1 
ATOM   216  C  CB   B LYS A 1 13  ? 13.58544  -18.89580 -6.15925  0.507 27.49118 ? 13  LYS A CB   1 
ATOM   217  C  CG   A LYS A 1 13  ? 15.06879  -19.28220 -5.92086  0.493 31.77266 ? 13  LYS A CG   1 
ATOM   218  C  CG   B LYS A 1 13  ? 15.05475  -19.30196 -6.03199  0.507 31.88302 ? 13  LYS A CG   1 
ATOM   219  C  CD   A LYS A 1 13  ? 15.50498  -20.11683 -7.11643  0.493 39.26641 ? 13  LYS A CD   1 
ATOM   220  C  CD   B LYS A 1 13  ? 15.55200  -19.99667 -7.29153  0.507 39.50800 ? 13  LYS A CD   1 
ATOM   221  C  CE   A LYS A 1 13  ? 17.01239  -20.06690 -7.31205  0.493 48.28643 ? 13  LYS A CE   1 
ATOM   222  C  CE   B LYS A 1 13  ? 17.06304  -20.21493 -7.27773  0.507 48.21403 ? 13  LYS A CE   1 
ATOM   223  N  NZ   A LYS A 1 13  ? 17.72318  -20.48353 -6.07541  0.493 46.46067 ? 13  LYS A NZ   1 
ATOM   224  N  NZ   B LYS A 1 13  ? 17.40730  -21.60788 -7.68887  0.507 54.78675 ? 13  LYS A NZ   1 
ATOM   225  H  H    A LYS A 1 13  ? 11.28796  -18.32676 -5.82833  0.493 29.20868 ? 13  LYS A H    1 
ATOM   226  H  H    B LYS A 1 13  ? 11.26828  -18.28920 -5.84245  0.507 29.20031 ? 13  LYS A H    1 
ATOM   227  H  HA   A LYS A 1 13  ? 13.09480  -19.17668 -4.15030  0.493 31.62108 ? 13  LYS A HA   1 
ATOM   228  H  HA   B LYS A 1 13  ? 13.00855  -19.34238 -4.22935  0.507 31.33350 ? 13  LYS A HA   1 
ATOM   229  H  HB2  A LYS A 1 13  ? 13.13691  -19.45929 -6.54738  0.493 33.34994 ? 13  LYS A HB2  1 
ATOM   230  H  HB2  B LYS A 1 13  ? 13.10776  -19.63107 -6.57410  0.507 32.99006 ? 13  LYS A HB2  1 
ATOM   231  H  HB3  A LYS A 1 13  ? 13.68184  -17.96897 -6.63350  0.493 33.34994 ? 13  LYS A HB3  1 
ATOM   232  H  HB3  B LYS A 1 13  ? 13.54144  -18.10980 -6.72597  0.507 32.99006 ? 13  LYS A HB3  1 
ATOM   233  H  HG2  A LYS A 1 13  ? 15.67340  -18.52823 -5.83789  0.493 38.12783 ? 13  LYS A HG2  1 
ATOM   234  H  HG2  B LYS A 1 13  ? 15.59569  -18.51000 -5.88678  0.507 38.26027 ? 13  LYS A HG2  1 
ATOM   235  H  HG3  A LYS A 1 13  ? 15.11912  -19.83678 -5.12662  0.493 38.12783 ? 13  LYS A HG3  1 
ATOM   236  H  HG3  B LYS A 1 13  ? 15.15558  -19.91392 -5.28618  0.507 38.26027 ? 13  LYS A HG3  1 
ATOM   237  H  HD2  A LYS A 1 13  ? 15.24660  -21.04093 -6.97441  0.493 47.12033 ? 13  LYS A HD2  1 
ATOM   238  H  HD2  B LYS A 1 13  ? 15.12331  -20.86354 -7.36671  0.507 47.41024 ? 13  LYS A HD2  1 
ATOM   239  H  HD3  A LYS A 1 13  ? 15.08204  -19.77370 -7.91911  0.493 47.12033 ? 13  LYS A HD3  1 
ATOM   240  H  HD3  B LYS A 1 13  ? 15.33376  -19.45061 -8.06295  0.507 47.41024 ? 13  LYS A HD3  1 
ATOM   241  H  HE2  A LYS A 1 13  ? 17.26527  -20.66885 -8.02941  0.493 57.94436 ? 13  LYS A HE2  1 
ATOM   242  H  HE2  B LYS A 1 13  ? 17.48387  -19.59903 -7.89778  0.507 57.85748 ? 13  LYS A HE2  1 
ATOM   243  H  HE3  A LYS A 1 13  ? 17.28015  -19.16037 -7.52976  0.493 57.94436 ? 13  LYS A HE3  1 
ATOM   244  H  HE3  B LYS A 1 13  ? 17.40245  -20.06678 -6.38121  0.507 57.85748 ? 13  LYS A HE3  1 
ATOM   245  H  HZ1  A LYS A 1 13  ? 18.53395  -20.78924 -6.27864  0.493 55.75344 ? 13  LYS A HZ1  1 
ATOM   246  H  HZ1  B LYS A 1 13  ? 18.29041  -21.69620 -7.75527  0.507 65.74474 ? 13  LYS A HZ1  1 
ATOM   247  H  HZ2  A LYS A 1 13  ? 17.80590  -19.79016 -5.52359  0.493 55.75344 ? 13  LYS A HZ2  1 
ATOM   248  H  HZ2  B LYS A 1 13  ? 17.10365  -22.18724 -7.08534  0.507 65.74474 ? 13  LYS A HZ2  1 
ATOM   249  H  HZ3  A LYS A 1 13  ? 17.26653  -21.12721 -5.66402  0.493 55.75344 ? 13  LYS A HZ3  1 
ATOM   250  H  HZ3  B LYS A 1 13  ? 17.03845  -21.79243 -8.47754  0.507 65.74474 ? 13  LYS A HZ3  1 
ATOM   251  N  N    A ARG A 1 14  ? 13.24156  -16.02709 -4.75783  0.493 24.79224 ? 14  ARG A N    1 
ATOM   252  N  N    B ARG A 1 14  ? 13.33908  -16.17697 -4.65512  0.507 25.15849 ? 14  ARG A N    1 
ATOM   253  C  CA   A ARG A 1 14  ? 13.79455  -14.78242 -4.24413  0.493 24.53075 ? 14  ARG A CA   1 
ATOM   254  C  CA   B ARG A 1 14  ? 14.00041  -15.00303 -4.10364  0.507 24.88491 ? 14  ARG A CA   1 
ATOM   255  C  C    A ARG A 1 14  ? 13.47304  -14.60687 -2.77051  0.493 33.46234 ? 14  ARG A C    1 
ATOM   256  C  C    B ARG A 1 14  ? 13.55695  -14.74192 -2.67779  0.507 33.35468 ? 14  ARG A C    1 
ATOM   257  O  O    A ARG A 1 14  ? 14.26405  -14.01517 -2.02992  0.493 30.03338 ? 14  ARG A O    1 
ATOM   258  O  O    B ARG A 1 14  ? 14.33386  -14.20739 -1.88093  0.507 30.23286 ? 14  ARG A O    1 
ATOM   259  C  CB   A ARG A 1 14  ? 13.27011  -13.60981 -5.07155  0.493 27.54383 ? 14  ARG A CB   1 
ATOM   260  C  CB   B ARG A 1 14  ? 13.76270  -13.76524 -4.97233  0.507 30.40003 ? 14  ARG A CB   1 
ATOM   261  C  CG   A ARG A 1 14  ? 13.79485  -12.25783 -4.63246  0.493 40.29279 ? 14  ARG A CG   1 
ATOM   262  C  CG   B ARG A 1 14  ? 14.71525  -12.62812 -4.61044  0.507 45.67147 ? 14  ARG A CG   1 
ATOM   263  C  CD   A ARG A 1 14  ? 13.55939  -11.19900 -5.70085  0.493 42.37851 ? 14  ARG A CD   1 
ATOM   264  C  CD   B ARG A 1 14  ? 14.47801  -11.36808 -5.42114  0.507 46.67333 ? 14  ARG A CD   1 
ATOM   265  N  NE   A ARG A 1 14  ? 12.24566  -10.57625 -5.58869  0.493 44.20810 ? 14  ARG A NE   1 
ATOM   266  N  NE   B ARG A 1 14  ? 13.86790  -10.31206 -4.61988  0.507 45.29901 ? 14  ARG A NE   1 
ATOM   267  C  CZ   A ARG A 1 14  ? 11.92546  -9.65114  -4.69497  0.493 39.98524 ? 14  ARG A CZ   1 
ATOM   268  C  CZ   B ARG A 1 14  ? 14.51642  -9.56599  -3.73380  0.507 42.68245 ? 14  ARG A CZ   1 
ATOM   269  N  NH1  A ARG A 1 14  ? 12.80420  -9.20915  -3.81120  0.493 45.41363 ? 14  ARG A NH1  1 
ATOM   270  N  NH1  B ARG A 1 14  ? 15.80202  -9.75037  -3.48053  0.507 37.10923 ? 14  ARG A NH1  1 
ATOM   271  N  NH2  A ARG A 1 14  ? 10.68891  -9.16199  -4.68312  0.493 52.01394 ? 14  ARG A NH2  1 
ATOM   272  N  NH2  B ARG A 1 14  ? 13.85625  -8.61316  -3.08184  0.507 50.23445 ? 14  ARG A NH2  1 
ATOM   273  H  H    A ARG A 1 14  ? 12.72574  -15.94276 -5.44078  0.493 29.75133 ? 14  ARG A H    1 
ATOM   274  H  H    B ARG A 1 14  ? 12.76823  -16.01388 -5.27731  0.507 30.19083 ? 14  ARG A H    1 
ATOM   275  H  HA   A ARG A 1 14  ? 14.76059  -14.79209 -4.33116  0.493 29.43754 ? 14  ARG A HA   1 
ATOM   276  H  HA   B ARG A 1 14  ? 14.95642  -15.16716 -4.10654  0.507 29.86253 ? 14  ARG A HA   1 
ATOM   277  H  HB2  A ARG A 1 14  ? 13.53166  -13.74105 -5.99635  0.493 33.05324 ? 14  ARG A HB2  1 
ATOM   278  H  HB2  B ARG A 1 14  ? 13.90442  -13.99653 -5.90363  0.507 36.48068 ? 14  ARG A HB2  1 
ATOM   279  H  HB3  A ARG A 1 14  ? 12.30299  -13.58769 -5.00024  0.493 33.05324 ? 14  ARG A HB3  1 
ATOM   280  H  HB3  B ARG A 1 14  ? 12.85330  -13.45372 -4.84254  0.507 36.48068 ? 14  ARG A HB3  1 
ATOM   281  H  HG2  A ARG A 1 14  ? 13.33706  -11.98221 -3.82292  0.493 48.35199 ? 14  ARG A HG2  1 
ATOM   282  H  HG2  B ARG A 1 14  ? 14.59814  -12.40560 -3.67360  0.507 54.80641 ? 14  ARG A HG2  1 
ATOM   283  H  HG3  A ARG A 1 14  ? 14.74896  -12.32032 -4.46917  0.493 48.35199 ? 14  ARG A HG3  1 
ATOM   284  H  HG3  B ARG A 1 14  ? 15.62685  -12.91805 -4.77112  0.507 54.80641 ? 14  ARG A HG3  1 
ATOM   285  H  HD2  A ARG A 1 14  ? 14.23036  -10.50412 -5.61228  0.493 50.85485 ? 14  ARG A HD2  1 
ATOM   286  H  HD2  B ARG A 1 14  ? 15.32643  -11.04089 -5.75882  0.507 56.00864 ? 14  ARG A HD2  1 
ATOM   287  H  HD3  A ARG A 1 14  ? 13.62293  -11.61189 -6.57628  0.493 50.85485 ? 14  ARG A HD3  1 
ATOM   288  H  HD3  B ARG A 1 14  ? 13.88284  -11.57067 -6.15980  0.507 56.00864 ? 14  ARG A HD3  1 
ATOM   289  H  HE   A ARG A 1 14  ? 11.63591  -10.82669 -6.14103  0.493 53.05036 ? 14  ARG A HE   1 
ATOM   290  H  HE   B ARG A 1 14  ? 13.02817  -10.16231 -4.72952  0.507 54.35945 ? 14  ARG A HE   1 
ATOM   291  H  HH11 A ARG A 1 14  ? 13.60506  -9.52253  -3.80739  0.493 54.49699 ? 14  ARG A HH11 1 
ATOM   292  H  HH11 B ARG A 1 14  ? 16.23786  -10.36561 -3.89421  0.507 44.53171 ? 14  ARG A HH11 1 
ATOM   293  H  HH12 A ARG A 1 14  ? 12.57483  -8.60832  -3.24024  0.493 54.49699 ? 14  ARG A HH12 1 
ATOM   294  H  HH12 B ARG A 1 14  ? 16.20173  -9.25496  -2.90226  0.507 44.53171 ? 14  ARG A HH12 1 
ATOM   295  H  HH21 A ARG A 1 14  ? 10.10861  -9.44619  -5.25063  0.493 62.41737 ? 14  ARG A HH21 1 
ATOM   296  H  HH21 B ARG A 1 14  ? 13.01980  -8.48663  -3.23657  0.507 60.28198 ? 14  ARG A HH21 1 
ATOM   297  H  HH22 A ARG A 1 14  ? 10.46954  -8.56146  -4.10793  0.493 62.41737 ? 14  ARG A HH22 1 
ATOM   298  H  HH22 B ARG A 1 14  ? 14.26580  -8.12355  -2.50551  0.507 60.28198 ? 14  ARG A HH22 1 
ATOM   299  N  N    . HIS A 1 15  ? 12.32079  -15.11800 -2.33063  1.000 26.42202 ? 15  HIS A N    1 
ATOM   300  C  CA   . HIS A 1 15  ? 11.84270  -14.95765 -0.96769  1.000 25.19006 ? 15  HIS A CA   1 
ATOM   301  C  C    . HIS A 1 15  ? 12.22224  -16.11810 -0.05746  1.000 28.27768 ? 15  HIS A C    1 
ATOM   302  O  O    . HIS A 1 15  ? 11.76911  -16.14980 1.08819   1.000 33.02081 ? 15  HIS A O    1 
ATOM   303  C  CB   . HIS A 1 15  ? 10.32485  -14.75065 -0.96630  1.000 29.75292 ? 15  HIS A CB   1 
ATOM   304  C  CG   . HIS A 1 15  ? 9.90202   -13.39209 -1.42808  1.000 26.86750 ? 15  HIS A CG   1 
ATOM   305  N  ND1  . HIS A 1 15  ? 9.85042   -12.30398 -0.58447  1.000 39.20902 ? 15  HIS A ND1  1 
ATOM   306  C  CD2  . HIS A 1 15  ? 9.52818   -12.94110 -2.64924  1.000 27.47293 ? 15  HIS A CD2  1 
ATOM   307  C  CE1  . HIS A 1 15  ? 9.45415   -11.24172 -1.26557  1.000 40.47261 ? 15  HIS A CE1  1 
ATOM   308  N  NE2  . HIS A 1 15  ? 9.24585   -11.60149 -2.51898  1.000 40.40867 ? 15  HIS A NE2  1 
ATOM   309  H  H    . HIS A 1 15  ? 11.74659  -15.46650 -2.86770  1.000 31.70706 ? 15  HIS A H    1 
ATOM   310  H  HA   . HIS A 1 15  ? 12.24879  -14.16059 -0.59260  1.000 30.22872 ? 15  HIS A HA   1 
ATOM   311  H  HB2  . HIS A 1 15  ? 9.92037   -15.40388 -1.55840  1.000 35.70415 ? 15  HIS A HB2  1 
ATOM   312  H  HB3  . HIS A 1 15  ? 9.99422   -14.87246 -0.06256  1.000 35.70415 ? 15  HIS A HB3  1 
ATOM   313  H  HD1  . HIS A 1 15  ? 10.04522  -12.31394 0.25311   1.000 47.05147 ? 15  HIS A HD1  1 
ATOM   314  H  HD2  . HIS A 1 15  ? 9.47277   -13.44345 -3.42993  1.000 32.96816 ? 15  HIS A HD2  1 
ATOM   315  H  HE1  . HIS A 1 15  ? 9.34123   -10.38572 -0.92002  1.000 48.56777 ? 15  HIS A HE1  1 
ATOM   316  N  N    . GLY A 1 16  ? 13.06192  -17.03587 -0.52381  1.000 26.94017 ? 16  GLY A N    1 
ATOM   317  C  CA   . GLY A 1 16  ? 13.66506  -18.02289 0.34634   1.000 29.18450 ? 16  GLY A CA   1 
ATOM   318  C  C    . GLY A 1 16  ? 12.89093  -19.30686 0.52289   1.000 28.61223 ? 16  GLY A C    1 
ATOM   319  O  O    . GLY A 1 16  ? 13.16465  -20.05273 1.46598   1.000 28.42514 ? 16  GLY A O    1 
ATOM   320  H  H    . GLY A 1 16  ? 13.29731  -17.10449 -1.34812  1.000 32.32884 ? 16  GLY A H    1 
ATOM   321  H  HA2  . GLY A 1 16  ? 14.53651  -18.25482 -0.01099  1.000 35.02204 ? 16  GLY A HA2  1 
ATOM   322  H  HA3  . GLY A 1 16  ? 13.77892  -17.62810 1.22502   1.000 35.02204 ? 16  GLY A HA3  1 
ATOM   323  N  N    . LEU A 1 17  ? 11.96241  -19.61111 -0.36538  1.000 29.86544 ? 17  LEU A N    1 
ATOM   324  C  CA   . LEU A 1 17  ? 11.16184  -20.80989 -0.17166  1.000 24.63859 ? 17  LEU A CA   1 
ATOM   325  C  C    . LEU A 1 17  ? 11.79109  -22.06905 -0.72577  1.000 28.30155 ? 17  LEU A C    1 
ATOM   326  O  O    . LEU A 1 17  ? 11.36488  -23.16394 -0.35373  1.000 25.05610 ? 17  LEU A O    1 
ATOM   327  C  CB   . LEU A 1 17  ? 9.78787   -20.65062 -0.81185  1.000 26.59652 ? 17  LEU A CB   1 
ATOM   328  C  CG   . LEU A 1 17  ? 8.83373   -19.88421 0.05923   1.000 26.91496 ? 17  LEU A CG   1 
ATOM   329  C  CD1  . LEU A 1 17  ? 7.48584   -19.85426 -0.59100  1.000 26.04669 ? 17  LEU A CD1  1 
ATOM   330  C  CD2  . LEU A 1 17  ? 8.66080   -20.49346 1.44383   1.000 26.81613 ? 17  LEU A CD2  1 
ATOM   331  H  H    . LEU A 1 17  ? 11.77979  -19.15353 -1.07027  1.000 35.83917 ? 17  LEU A H    1 
ATOM   332  H  HA   . LEU A 1 17  ? 11.04999  -20.92345 0.78516   1.000 29.56695 ? 17  LEU A HA   1 
ATOM   333  H  HB2  . LEU A 1 17  ? 9.88323   -20.17166 -1.64994  1.000 31.91647 ? 17  LEU A HB2  1 
ATOM   334  H  HB3  . LEU A 1 17  ? 9.41045   -21.52951 -0.97310  1.000 31.91647 ? 17  LEU A HB3  1 
ATOM   335  H  HG   . LEU A 1 17  ? 9.20381   -18.99436 0.16933   1.000 32.29860 ? 17  LEU A HG   1 
ATOM   336  H  HD11 . LEU A 1 17  ? 6.88919   -19.30776 -0.05598  1.000 31.25667 ? 17  LEU A HD11 1 
ATOM   337  H  HD12 . LEU A 1 17  ? 7.57247   -19.47634 -1.48014  1.000 31.25667 ? 17  LEU A HD12 1 
ATOM   338  H  HD13 . LEU A 1 17  ? 7.14273   -20.75973 -0.64843  1.000 31.25667 ? 17  LEU A HD13 1 
ATOM   339  H  HD21 . LEU A 1 17  ? 7.82034   -20.18873 1.82022   1.000 32.17999 ? 17  LEU A HD21 1 
ATOM   340  H  HD22 . LEU A 1 17  ? 8.65680   -21.46026 1.36519   1.000 32.17999 ? 17  LEU A HD22 1 
ATOM   341  H  HD23 . LEU A 1 17  ? 9.39766   -20.21050 2.00764   1.000 32.17999 ? 17  LEU A HD23 1 
ATOM   342  N  N    A ASP A 1 18  ? 12.76682  -21.96559 -1.62040  0.570 28.43741 ? 18  ASP A N    1 
ATOM   343  N  N    B ASP A 1 18  ? 12.80941  -21.96480 -1.57270  0.430 28.26920 ? 18  ASP A N    1 
ATOM   344  C  CA   A ASP A 1 18  ? 13.35938  -23.16664 -2.17911  0.570 25.78947 ? 18  ASP A CA   1 
ATOM   345  C  CA   B ASP A 1 18  ? 13.39188  -23.15269 -2.18015  0.430 25.91838 ? 18  ASP A CA   1 
ATOM   346  C  C    A ASP A 1 18  ? 14.06485  -23.93104 -1.07529  0.570 29.54092 ? 18  ASP A C    1 
ATOM   347  C  C    B ASP A 1 18  ? 14.10242  -23.97770 -1.11395  0.430 29.51209 ? 18  ASP A C    1 
ATOM   348  O  O    A ASP A 1 18  ? 14.98389  -23.40318 -0.43530  0.570 29.41616 ? 18  ASP A O    1 
ATOM   349  O  O    B ASP A 1 18  ? 15.10169  -23.53628 -0.53546  0.430 30.45531 ? 18  ASP A O    1 
ATOM   350  C  CB   A ASP A 1 18  ? 14.34182  -22.81068 -3.29564  0.570 28.74250 ? 18  ASP A CB   1 
ATOM   351  C  CB   B ASP A 1 18  ? 14.33924  -22.76993 -3.31523  0.430 28.79826 ? 18  ASP A CB   1 
ATOM   352  C  CG   A ASP A 1 18  ? 14.72459  -24.01504 -4.15897  0.570 33.01944 ? 18  ASP A CG   1 
ATOM   353  C  CG   B ASP A 1 18  ? 15.35499  -21.71800 -2.91211  0.430 36.62125 ? 18  ASP A CG   1 
ATOM   354  O  OD1  A ASP A 1 18  ? 14.18406  -25.12379 -3.95774  0.570 28.84135 ? 18  ASP A OD1  1 
ATOM   355  O  OD1  B ASP A 1 18  ? 14.94898  -20.64417 -2.41707  0.430 30.40104 ? 18  ASP A OD1  1 
ATOM   356  O  OD2  A ASP A 1 18  ? 15.57300  -23.84691 -5.06507  0.570 35.66445 ? 18  ASP A OD2  1 
ATOM   357  O  OD2  B ASP A 1 18  ? 16.56390  -21.96400 -3.11512  0.430 43.25894 ? 18  ASP A OD2  1 
ATOM   358  H  H    A ASP A 1 18  ? 13.09481  -21.22621 -1.91254  0.570 34.12554 ? 18  ASP A H    1 
ATOM   359  H  H    B ASP A 1 18  ? 13.17674  -21.22392 -1.80884  0.430 33.92368 ? 18  ASP A H    1 
ATOM   360  H  HA   A ASP A 1 18  ? 12.66655  -23.72407 -2.56662  0.570 30.94801 ? 18  ASP A HA   1 
ATOM   361  H  HA   B ASP A 1 18  ? 12.68170  -23.69339 -2.55987  0.430 31.10270 ? 18  ASP A HA   1 
ATOM   362  H  HB2  A ASP A 1 18  ? 13.93562  -22.14553 -3.87311  0.570 34.49165 ? 18  ASP A HB2  1 
ATOM   363  H  HB2  B ASP A 1 18  ? 14.82455  -23.55994 -3.60032  0.430 34.55856 ? 18  ASP A HB2  1 
ATOM   364  H  HB3  A ASP A 1 18  ? 15.15344  -22.45574 -2.90043  0.570 34.49165 ? 18  ASP A HB3  1 
ATOM   365  H  HB3  B ASP A 1 18  ? 13.81928  -22.41560 -4.05346  0.430 34.55856 ? 18  ASP A HB3  1 
ATOM   366  N  N    A ASN A 1 19  ? 13.60449  -25.16439 -0.84246  0.625 25.63480 ? 19  ASN A N    1 
ATOM   367  N  N    B ASN A 1 19  ? 13.57773  -25.18045 -0.86157  0.375 25.73285 ? 19  ASN A N    1 
ATOM   368  C  CA   A ASN A 1 19  ? 14.10798  -26.06393 0.18581   0.625 23.90125 ? 19  ASN A CA   1 
ATOM   369  C  CA   B ASN A 1 19  ? 14.04073  -26.10383 0.17077   0.375 24.11456 ? 19  ASN A CA   1 
ATOM   370  C  C    A ASN A 1 19  ? 13.87335  -25.54791 1.59672   0.625 24.41248 ? 19  ASN A C    1 
ATOM   371  C  C    B ASN A 1 19  ? 13.85246  -25.56784 1.58676   0.375 24.45880 ? 19  ASN A C    1 
ATOM   372  O  O    A ASN A 1 19  ? 14.49129  -26.03502 2.55004   0.625 26.56133 ? 19  ASN A O    1 
ATOM   373  O  O    B ASN A 1 19  ? 14.49712  -26.04799 2.52522   0.375 26.52410 ? 19  ASN A O    1 
ATOM   374  C  CB   A ASN A 1 19  ? 15.57143  -26.44074 -0.06925  0.625 28.10820 ? 19  ASN A CB   1 
ATOM   375  C  CB   B ASN A 1 19  ? 15.47658  -26.58675 -0.06667  0.375 29.01811 ? 19  ASN A CB   1 
ATOM   376  C  CG   A ASN A 1 19  ? 15.73512  -27.24785 -1.34164  0.625 29.00559 ? 19  ASN A CG   1 
ATOM   377  C  CG   B ASN A 1 19  ? 15.63893  -28.06869 0.22058   0.375 28.01261 ? 19  ASN A CG   1 
ATOM   378  O  OD1  A ASN A 1 19  ? 15.12808  -28.30861 -1.50312  0.625 39.35251 ? 19  ASN A OD1  1 
ATOM   379  O  OD1  B ASN A 1 19  ? 14.72828  -28.87010 -0.01584  0.375 33.00225 ? 19  ASN A OD1  1 
ATOM   380  N  ND2  A ASN A 1 19  ? 16.55130  -26.74443 -2.25788  0.625 41.05186 ? 19  ASN A ND2  1 
ATOM   381  N  ND2  B ASN A 1 19  ? 16.80647  -28.44253 0.74005   0.375 36.38651 ? 19  ASN A ND2  1 
ATOM   382  H  H    A ASN A 1 19  ? 12.96446  -25.51687 -1.29602  0.625 30.76240 ? 19  ASN A H    1 
ATOM   383  H  H    B ASN A 1 19  ? 12.91277  -25.49988 -1.30361  0.375 30.88006 ? 19  ASN A H    1 
ATOM   384  H  HA   A ASN A 1 19  ? 13.60364  -26.89116 0.13864   0.625 28.68214 ? 19  ASN A HA   1 
ATOM   385  H  HA   B ASN A 1 19  ? 13.48114  -26.89383 0.11024   0.375 28.93812 ? 19  ASN A HA   1 
ATOM   386  H  HB2  A ASN A 1 19  ? 16.09943  -25.63139 -0.15336  0.625 33.73048 ? 19  ASN A HB2  1 
ATOM   387  H  HB2  B ASN A 1 19  ? 15.71552  -26.43067 -0.99373  0.375 34.82237 ? 19  ASN A HB2  1 
ATOM   388  H  HB3  A ASN A 1 19  ? 15.89764  -26.97409 0.67239   0.625 33.73048 ? 19  ASN A HB3  1 
ATOM   389  H  HB3  B ASN A 1 19  ? 16.07728  -26.09811 0.51754   0.375 34.82237 ? 19  ASN A HB3  1 
ATOM   390  H  HD21 A ASN A 1 19  ? 16.67841  -27.16411 -2.99769  0.625 49.26287 ? 19  ASN A HD21 1 
ATOM   391  H  HD21 B ASN A 1 19  ? 16.95081  -29.27061 0.92183   0.375 43.66445 ? 19  ASN A HD21 1 
ATOM   392  H  HD22 A ASN A 1 19  ? 16.95341  -25.99832 -2.11219  0.625 49.26287 ? 19  ASN A HD22 1 
ATOM   393  H  HD22 B ASN A 1 19  ? 17.41626  -27.85592 0.89379   0.375 43.66445 ? 19  ASN A HD22 1 
ATOM   394  N  N    . TYR A 1 20  ? 12.94788  -24.61214 1.78205   1.000 24.41560 ? 20  TYR A N    1 
ATOM   395  C  CA   . TYR A 1 20  ? 12.62278  -24.16837 3.12673   1.000 23.69384 ? 20  TYR A CA   1 
ATOM   396  C  C    . TYR A 1 20  ? 11.99586  -25.32658 3.89638   1.000 25.14332 ? 20  TYR A C    1 
ATOM   397  O  O    . TYR A 1 20  ? 11.01208  -25.93151 3.44689   1.000 24.06496 ? 20  TYR A O    1 
ATOM   398  C  CB   . TYR A 1 20  ? 11.69646  -22.94799 3.11680   1.000 24.83529 ? 20  TYR A CB   1 
ATOM   399  C  CG   . TYR A 1 20  ? 11.54787  -22.31245 4.47020   1.000 25.05258 ? 20  TYR A CG   1 
ATOM   400  C  CD1  . TYR A 1 20  ? 12.49793  -21.42569 4.95495   1.000 29.11516 ? 20  TYR A CD1  1 
ATOM   401  C  CD2  . TYR A 1 20  ? 10.47764  -22.63302 5.28723   1.000 26.40165 ? 20  TYR A CD2  1 
ATOM   402  C  CE1  . TYR A 1 20  ? 12.36364  -20.87144 6.20274   1.000 32.54003 ? 20  TYR A CE1  1 
ATOM   403  C  CE2  . TYR A 1 20  ? 10.33662  -22.09802 6.50442   1.000 26.94374 ? 20  TYR A CE2  1 
ATOM   404  C  CZ   . TYR A 1 20  ? 11.28572  -21.22054 6.97984   1.000 29.98705 ? 20  TYR A CZ   1 
ATOM   405  O  OH   . TYR A 1 20  ? 11.15634  -20.65654 8.23124   1.000 35.35083 ? 20  TYR A OH   1 
ATOM   406  H  H    . TYR A 1 20  ? 12.50395  -24.22778 1.15372   1.000 29.29936 ? 20  TYR A H    1 
ATOM   407  H  HA   . TYR A 1 20  ? 13.43428  -23.88613 3.57696   1.000 28.43325 ? 20  TYR A HA   1 
ATOM   408  H  HB2  . TYR A 1 20  ? 12.05937  -22.28229 2.51179   1.000 29.80299 ? 20  TYR A HB2  1 
ATOM   409  H  HB3  . TYR A 1 20  ? 10.81598  -23.22359 2.81730   1.000 29.80299 ? 20  TYR A HB3  1 
ATOM   410  H  HD1  . TYR A 1 20  ? 13.23267  -21.20482 4.42933   1.000 34.93884 ? 20  TYR A HD1  1 
ATOM   411  H  HD2  . TYR A 1 20  ? 9.83964   -23.23662 4.98143   1.000 31.68263 ? 20  TYR A HD2  1 
ATOM   412  H  HE1  . TYR A 1 20  ? 12.99507  -20.26630 6.51898   1.000 39.04867 ? 20  TYR A HE1  1 
ATOM   413  H  HE2  . TYR A 1 20  ? 9.60019   -22.31766 7.02820   1.000 32.33313 ? 20  TYR A HE2  1 
ATOM   414  H  HH   . TYR A 1 20  ? 10.65016  -21.12792 8.70789   1.000 42.42164 ? 20  TYR A HH   1 
ATOM   415  N  N    A ARG A 1 21  ? 12.57464  -25.63693 5.05658   0.516 24.10931 ? 21  ARG A N    1 
ATOM   416  N  N    B ARG A 1 21  ? 12.57158  -25.63324 5.05936   0.484 24.11687 ? 21  ARG A N    1 
ATOM   417  C  CA   A ARG A 1 21  ? 12.17868  -26.78287 5.86769   0.516 24.59466 ? 21  ARG A CA   1 
ATOM   418  C  CA   B ARG A 1 21  ? 12.18566  -26.78650 5.86817   0.484 24.62870 ? 21  ARG A CA   1 
ATOM   419  C  C    A ARG A 1 21  ? 12.18651  -28.07638 5.05312   0.516 22.50192 ? 21  ARG A C    1 
ATOM   420  C  C    B ARG A 1 21  ? 12.18799  -28.07714 5.05087   0.484 22.50550 ? 21  ARG A C    1 
ATOM   421  O  O    A ARG A 1 21  ? 11.42344  -29.00628 5.32305   0.516 25.63607 ? 21  ARG A O    1 
ATOM   422  O  O    B ARG A 1 21  ? 11.42132  -29.00524 5.31821   0.484 25.62720 ? 21  ARG A O    1 
ATOM   423  C  CB   A ARG A 1 21  ? 10.84299  -26.53831 6.57418   0.516 28.49003 ? 21  ARG A CB   1 
ATOM   424  C  CB   B ARG A 1 21  ? 10.85571  -26.55801 6.58771   0.484 28.48918 ? 21  ARG A CB   1 
ATOM   425  C  CG   A ARG A 1 21  ? 10.92563  -25.53871 7.71607   0.516 39.49618 ? 21  ARG A CG   1 
ATOM   426  C  CG   B ARG A 1 21  ? 10.86561  -25.38186 7.53690   0.484 38.89142 ? 21  ARG A CG   1 
ATOM   427  C  CD   A ARG A 1 21  ? 11.07293  -26.22201 9.07103   0.516 37.20399 ? 21  ARG A CD   1 
ATOM   428  C  CD   B ARG A 1 21  ? 11.58388  -25.71218 8.83700   0.484 39.43603 ? 21  ARG A CD   1 
ATOM   429  N  NE   A ARG A 1 21  ? 11.41779  -25.27389 10.12781  0.516 47.73736 ? 21  ARG A NE   1 
ATOM   430  N  NE   B ARG A 1 21  ? 11.73571  -24.52761 9.67620   0.484 42.31529 ? 21  ARG A NE   1 
ATOM   431  C  CZ   A ARG A 1 21  ? 11.30246  -25.51868 11.42698  0.516 45.68820 ? 21  ARG A CZ   1 
ATOM   432  C  CZ   B ARG A 1 21  ? 12.82530  -23.77282 9.73246   0.484 43.37729 ? 21  ARG A CZ   1 
ATOM   433  N  NH1  A ARG A 1 21  ? 10.81977  -26.66576 11.87503  0.516 43.27760 ? 21  ARG A NH1  1 
ATOM   434  N  NH1  B ARG A 1 21  ? 13.91136  -24.06734 9.03308   0.484 50.98967 ? 21  ARG A NH1  1 
ATOM   435  N  NH2  A ARG A 1 21  ? 11.67386  -24.58467 12.29916  0.516 48.80410 ? 21  ARG A NH2  1 
ATOM   436  N  NH2  B ARG A 1 21  ? 12.82756  -22.69680 10.51387  0.484 50.15139 ? 21  ARG A NH2  1 
ATOM   437  H  H    A ARG A 1 21  ? 13.21811  -25.18432 5.40401   0.516 28.93182 ? 21  ARG A H    1 
ATOM   438  H  H    B ARG A 1 21  ? 13.20772  -25.17372 5.41116   0.484 28.94088 ? 21  ARG A H    1 
ATOM   439  H  HA   A ARG A 1 21  ? 12.83644  -26.90544 6.56999   0.516 29.51423 ? 21  ARG A HA   1 
ATOM   440  H  HA   B ARG A 1 21  ? 12.85356  -26.90383 6.56175   0.484 29.55508 ? 21  ARG A HA   1 
ATOM   441  H  HB2  A ARG A 1 21  ? 10.20650  -26.19616 5.92711   0.516 34.18867 ? 21  ARG A HB2  1 
ATOM   442  H  HB2  B ARG A 1 21  ? 10.16690  -26.39619 5.92419   0.484 34.18766 ? 21  ARG A HB2  1 
ATOM   443  H  HB3  A ARG A 1 21  ? 10.52539  -27.37893 6.93943   0.516 34.18867 ? 21  ARG A HB3  1 
ATOM   444  H  HB3  B ARG A 1 21  ? 10.64043  -27.35130 7.10273   0.484 34.18766 ? 21  ARG A HB3  1 
ATOM   445  H  HG2  A ARG A 1 21  ? 11.69618  -24.96497 7.58204   0.516 47.39606 ? 21  ARG A HG2  1 
ATOM   446  H  HG2  B ARG A 1 21  ? 11.32316  -24.63611 7.11809   0.484 46.67035 ? 21  ARG A HG2  1 
ATOM   447  H  HG3  A ARG A 1 21  ? 10.11476  -25.00663 7.73295   0.516 47.39606 ? 21  ARG A HG3  1 
ATOM   448  H  HG3  B ARG A 1 21  ? 9.95218   -25.13380 7.74907   0.484 46.67035 ? 21  ARG A HG3  1 
ATOM   449  H  HD2  A ARG A 1 21  ? 10.23345  -26.64671 9.30723   0.516 44.64543 ? 21  ARG A HD2  1 
ATOM   450  H  HD2  B ARG A 1 21  ? 11.07072  -26.37185 9.32934   0.484 47.32387 ? 21  ARG A HD2  1 
ATOM   451  H  HD3  A ARG A 1 21  ? 11.77764  -26.88648 9.01844   0.516 44.64543 ? 21  ARG A HD3  1 
ATOM   452  H  HD3  B ARG A 1 21  ? 12.46688  -26.06041 8.63713   0.484 47.32387 ? 21  ARG A HD3  1 
ATOM   453  H  HE   A ARG A 1 21  ? 11.71654  -24.50292 9.89128   0.516 57.28547 ? 21  ARG A HE   1 
ATOM   454  H  HE   B ARG A 1 21  ? 11.06935  -24.30221 10.17093  0.484 50.77899 ? 21  ARG A HE   1 
ATOM   455  H  HH11 A ARG A 1 21  ? 10.57190  -27.27409 11.31997  0.516 51.93376 ? 21  ARG A HH11 1 
ATOM   456  H  HH11 B ARG A 1 21  ? 13.92144  -24.76251 8.52689   0.484 61.18824 ? 21  ARG A HH11 1 
ATOM   457  H  HH12 A ARG A 1 21  ? 10.75381  -26.80324 12.72140  0.516 51.93376 ? 21  ARG A HH12 1 
ATOM   458  H  HH12 B ARG A 1 21  ? 14.60623  -23.56333 9.08530   0.484 61.18824 ? 21  ARG A HH12 1 
ATOM   459  H  HH21 A ARG A 1 21  ? 11.98420  -23.83333 12.01850  0.516 58.56556 ? 21  ARG A HH21 1 
ATOM   460  H  HH21 B ARG A 1 21  ? 12.12880  -22.49819 10.97419  0.484 60.18231 ? 21  ARG A HH21 1 
ATOM   461  H  HH22 A ARG A 1 21  ? 11.60354  -24.73244 13.14345  0.516 58.56556 ? 21  ARG A HH22 1 
ATOM   462  H  HH22 B ARG A 1 21  ? 13.52778  -22.19954 10.55889  0.484 60.18231 ? 21  ARG A HH22 1 
ATOM   463  N  N    . GLY A 1 22  ? 13.05741  -28.13855 4.04722   1.000 22.87971 ? 22  GLY A N    1 
ATOM   464  C  CA   . GLY A 1 22  ? 13.20954  -29.30627 3.21154   1.000 22.57843 ? 22  GLY A CA   1 
ATOM   465  C  C    . GLY A 1 22  ? 12.22214  -29.47033 2.07410   1.000 23.22479 ? 22  GLY A C    1 
ATOM   466  O  O    . GLY A 1 22  ? 12.22836  -30.51604 1.42821   1.000 24.10129 ? 22  GLY A O    1 
ATOM   467  H  H    . GLY A 1 22  ? 13.58324  -27.49396 3.82902   1.000 27.45629 ? 22  GLY A H    1 
ATOM   468  H  HA2  . GLY A 1 22  ? 14.09676  -29.28420 2.82008   1.000 27.09475 ? 22  GLY A HA2  1 
ATOM   469  H  HA3  . GLY A 1 22  ? 13.13206  -30.09265 3.77413   1.000 27.09475 ? 22  GLY A HA3  1 
ATOM   470  N  N    . TYR A 1 23  ? 11.38439  -28.47075 1.79568   1.000 23.09920 ? 23  TYR A N    1 
ATOM   471  C  CA   . TYR A 1 23  ? 10.41592  -28.55650 0.70737   1.000 21.54468 ? 23  TYR A CA   1 
ATOM   472  C  C    . TYR A 1 23  ? 10.95261  -27.83221 -0.51070  1.000 20.04168 ? 23  TYR A C    1 
ATOM   473  O  O    . TYR A 1 23  ? 11.06394  -26.60625 -0.51331  1.000 20.96471 ? 23  TYR A O    1 
ATOM   474  C  CB   . TYR A 1 23  ? 9.06786   -27.97736 1.13522   1.000 18.40693 ? 23  TYR A CB   1 
ATOM   475  C  CG   . TYR A 1 23  ? 8.38620   -28.84751 2.16145   1.000 16.15523 ? 23  TYR A CG   1 
ATOM   476  C  CD1  . TYR A 1 23  ? 7.56536   -29.87364 1.76906   1.000 18.70037 ? 23  TYR A CD1  1 
ATOM   477  C  CD2  . TYR A 1 23  ? 8.56606   -28.61994 3.54340   1.000 17.82224 ? 23  TYR A CD2  1 
ATOM   478  C  CE1  . TYR A 1 23  ? 6.95701   -30.68456 2.71161   1.000 17.08979 ? 23  TYR A CE1  1 
ATOM   479  C  CE2  . TYR A 1 23  ? 7.96032   -29.44306 4.51016   1.000 17.13868 ? 23  TYR A CE2  1 
ATOM   480  C  CZ   . TYR A 1 23  ? 7.11325   -30.45113 4.06969   1.000 18.63760 ? 23  TYR A CZ   1 
ATOM   481  O  OH   . TYR A 1 23  ? 6.46660   -31.30438 4.96069   1.000 20.43737 ? 23  TYR A OH   1 
ATOM   482  H  H    . TYR A 1 23  ? 11.35970  -27.72776 2.22805   1.000 27.71968 ? 23  TYR A H    1 
ATOM   483  H  HA   . TYR A 1 23  ? 10.29797  -29.48982 0.47091   1.000 25.85425 ? 23  TYR A HA   1 
ATOM   484  H  HB2  . TYR A 1 23  ? 9.20604   -27.09939 1.52376   1.000 22.08895 ? 23  TYR A HB2  1 
ATOM   485  H  HB3  . TYR A 1 23  ? 8.48859   -27.90972 0.36012   1.000 22.08895 ? 23  TYR A HB3  1 
ATOM   486  H  HD1  . TYR A 1 23  ? 7.41645   -30.02570 0.86374   1.000 22.44109 ? 23  TYR A HD1  1 
ATOM   487  H  HD2  . TYR A 1 23  ? 9.09756   -27.90908 3.82104   1.000 21.38733 ? 23  TYR A HD2  1 
ATOM   488  H  HE1  . TYR A 1 23  ? 6.43363   -31.39940 2.42881   1.000 20.50839 ? 23  TYR A HE1  1 
ATOM   489  H  HE2  . TYR A 1 23  ? 8.12239   -29.31581 5.41705   1.000 20.56706 ? 23  TYR A HE2  1 
ATOM   490  H  HH   . TYR A 1 23  ? 6.75922   -31.18279 5.73863   1.000 24.52549 ? 23  TYR A HH   1 
ATOM   491  N  N    . SER A 1 24  ? 11.24101  -28.60914 -1.54329  1.000 20.92800 ? 24  SER A N    1 
ATOM   492  C  CA   . SER A 1 24  ? 11.74906  -28.06311 -2.79230  1.000 22.39541 ? 24  SER A CA   1 
ATOM   493  C  C    . SER A 1 24  ? 10.73322  -27.11500 -3.42138  1.000 20.17221 ? 24  SER A C    1 
ATOM   494  O  O    . SER A 1 24  ? 9.50645   -27.18230 -3.18504  1.000 20.19106 ? 24  SER A O    1 
ATOM   495  C  CB   . SER A 1 24  ? 12.09191  -29.18252 -3.78402  1.000 21.43372 ? 24  SER A CB   1 
ATOM   496  O  OG   . SER A 1 24  ? 10.94118  -29.85607 -4.24917  1.000 28.28674 ? 24  SER A OG   1 
ATOM   497  H  H    . SER A 1 24  ? 11.15097  -29.46441 -1.54775  1.000 25.11425 ? 24  SER A H    1 
ATOM   498  H  HA   . SER A 1 24  ? 12.56114  -27.56612 -2.60673  1.000 26.87513 ? 24  SER A HA   1 
ATOM   499  H  HB2  . SER A 1 24  ? 12.55183  -28.79323 -4.54417  1.000 25.72110 ? 24  SER A HB2  1 
ATOM   500  H  HB3  . SER A 1 24  ? 12.66854  -29.82402 -3.34031  1.000 25.72110 ? 24  SER A HB3  1 
ATOM   501  H  HG   . SER A 1 24  ? 10.55578  -30.24140 -3.60997  1.000 33.94473 ? 24  SER A HG   1 
ATOM   502  N  N    . LEU A 1 25  ? 11.24557  -26.23141 -4.27318  1.000 20.79811 ? 25  LEU A N    1 
ATOM   503  C  CA   . LEU A 1 25  ? 10.43749  -25.19381 -4.87836  1.000 18.92280 ? 25  LEU A CA   1 
ATOM   504  C  C    . LEU A 1 25  ? 9.19069   -25.72382 -5.56238  1.000 19.42118 ? 25  LEU A C    1 
ATOM   505  O  O    . LEU A 1 25  ? 8.12553   -25.10027 -5.47461  1.000 19.53806 ? 25  LEU A O    1 
ATOM   506  C  CB   . LEU A 1 25  ? 11.30818  -24.39771 -5.85161  1.000 22.07160 ? 25  LEU A CB   1 
ATOM   507  C  CG   . LEU A 1 25  ? 10.77633  -23.07795 -6.34773  1.000 25.33708 ? 25  LEU A CG   1 
ATOM   508  C  CD1  . LEU A 1 25  ? 10.49516  -22.13849 -5.19870  1.000 29.06363 ? 25  LEU A CD1  1 
ATOM   509  C  CD2  . LEU A 1 25  ? 11.83671  -22.47348 -7.29462  1.000 26.51549 ? 25  LEU A CD2  1 
ATOM   510  H  H    . LEU A 1 25  ? 12.06992  -26.21468 -4.51763  1.000 24.95838 ? 25  LEU A H    1 
ATOM   511  H  HA   . LEU A 1 25  ? 10.11930  -24.60244 -4.17841  1.000 22.70801 ? 25  LEU A HA   1 
ATOM   512  H  HB2  . LEU A 1 25  ? 12.15135  -24.21144 -5.40972  1.000 26.48656 ? 25  LEU A HB2  1 
ATOM   513  H  HB3  . LEU A 1 25  ? 11.45879  -24.95081 -6.63410  1.000 26.48656 ? 25  LEU A HB3  1 
ATOM   514  H  HG   . LEU A 1 25  ? 9.93733   -23.20376 -6.81802  1.000 30.40513 ? 25  LEU A HG   1 
ATOM   515  H  HD11 . LEU A 1 25  ? 10.35534  -21.24465 -5.54855  1.000 34.87700 ? 25  LEU A HD11 1 
ATOM   516  H  HD12 . LEU A 1 25  ? 9.69966   -22.43931 -4.73223  1.000 34.87700 ? 25  LEU A HD12 1 
ATOM   517  H  HD13 . LEU A 1 25  ? 11.25413  -22.14231 -4.59468  1.000 34.87700 ? 25  LEU A HD13 1 
ATOM   518  H  HD21 . LEU A 1 25  ? 11.65840  -21.52641 -7.40492  1.000 31.81923 ? 25  LEU A HD21 1 
ATOM   519  H  HD22 . LEU A 1 25  ? 12.71638  -22.60144 -6.90641  1.000 31.81923 ? 25  LEU A HD22 1 
ATOM   520  H  HD23 . LEU A 1 25  ? 11.78567  -22.92188 -8.15324  1.000 31.81923 ? 25  LEU A HD23 1 
ATOM   521  N  N    . GLY A 1 26  ? 9.28422   -26.82996 -6.28483  1.000 18.65933 ? 26  GLY A N    1 
ATOM   522  C  CA   . GLY A 1 26  ? 8.11833   -27.36715 -6.96188  1.000 18.98002 ? 26  GLY A CA   1 
ATOM   523  C  C    . GLY A 1 26  ? 6.95037   -27.67177 -6.03780  1.000 19.68868 ? 26  GLY A C    1 
ATOM   524  O  O    . GLY A 1 26  ? 5.79230   -27.61003 -6.46332  1.000 19.46972 ? 26  GLY A O    1 
ATOM   525  H  H    . GLY A 1 26  ? 10.00515  -27.28494 -6.39820  1.000 22.39184 ? 26  GLY A H    1 
ATOM   526  H  HA2  . GLY A 1 26  ? 7.81605   -26.72580 -7.62385  1.000 22.77667 ? 26  GLY A HA2  1 
ATOM   527  H  HA3  . GLY A 1 26  ? 8.36696   -28.19052 -7.41038  1.000 22.77667 ? 26  GLY A HA3  1 
ATOM   528  N  N    . ASN A 1 27  ? 7.22642   -28.02425 -4.78480  1.000 17.10989 ? 27  ASN A N    1 
ATOM   529  C  CA   . ASN A 1 27  ? 6.13645   -28.26727 -3.83079  1.000 17.66714 ? 27  ASN A CA   1 
ATOM   530  C  C    . ASN A 1 27  ? 5.32314   -27.00543 -3.61775  1.000 18.48034 ? 27  ASN A C    1 
ATOM   531  O  O    . ASN A 1 27  ? 4.08758   -27.06144 -3.55773  1.000 17.59930 ? 27  ASN A O    1 
ATOM   532  C  CB   . ASN A 1 27  ? 6.68403   -28.72968 -2.48132  1.000 18.81072 ? 27  ASN A CB   1 
ATOM   533  C  CG   . ASN A 1 27  ? 7.08304   -30.15726 -2.48777  1.000 19.96055 ? 27  ASN A CG   1 
ATOM   534  O  OD1  . ASN A 1 27  ? 6.25570   -31.03707 -2.53001  1.000 20.12471 ? 27  ASN A OD1  1 
ATOM   535  N  ND2  . ASN A 1 27  ? 8.38840   -30.39673 -2.51816  1.000 21.40875 ? 27  ASN A ND2  1 
ATOM   536  H  H    . ASN A 1 27  ? 8.01730   -28.12866 -4.46354  1.000 20.53250 ? 27  ASN A H    1 
ATOM   537  H  HA   . ASN A 1 27  ? 5.57333   -28.96957 -4.19213  1.000 21.20121 ? 27  ASN A HA   1 
ATOM   538  H  HB2  . ASN A 1 27  ? 7.46549   -28.20008 -2.25828  1.000 22.57350 ? 27  ASN A HB2  1 
ATOM   539  H  HB3  . ASN A 1 27  ? 5.99926   -28.61195 -1.80446  1.000 22.57350 ? 27  ASN A HB3  1 
ATOM   540  H  HD21 . ASN A 1 27  ? 8.67694   -31.20686 -2.52329  1.000 25.69115 ? 27  ASN A HD21 1 
ATOM   541  H  HD22 . ASN A 1 27  ? 8.94551   -29.74174 -2.53272  1.000 25.69115 ? 27  ASN A HD22 1 
ATOM   542  N  N    . TRP A 1 28  ? 5.99567   -25.85811 -3.50554  1.000 17.94252 ? 28  TRP A N    1 
ATOM   543  C  CA   . TRP A 1 28  ? 5.30816   -24.60017 -3.24479  1.000 18.08908 ? 28  TRP A CA   1 
ATOM   544  C  C    . TRP A 1 28  ? 4.52601   -24.12704 -4.45990  1.000 18.35859 ? 28  TRP A C    1 
ATOM   545  O  O    . TRP A 1 28  ? 3.41680   -23.59687 -4.34022  1.000 18.49940 ? 28  TRP A O    1 
ATOM   546  C  CB   . TRP A 1 28  ? 6.33783   -23.55796 -2.81622  1.000 18.72449 ? 28  TRP A CB   1 
ATOM   547  C  CG   . TRP A 1 28  ? 7.03571   -23.91362 -1.54865  1.000 17.70806 ? 28  TRP A CG   1 
ATOM   548  C  CD1  . TRP A 1 28  ? 8.28583   -24.43714 -1.39943  1.000 20.96307 ? 28  TRP A CD1  1 
ATOM   549  C  CD2  . TRP A 1 28  ? 6.50838   -23.76212 -0.22255  1.000 17.52513 ? 28  TRP A CD2  1 
ATOM   550  N  NE1  . TRP A 1 28  ? 8.56450   -24.62776 -0.06524  1.000 20.76596 ? 28  TRP A NE1  1 
ATOM   551  C  CE2  . TRP A 1 28  ? 7.48066   -24.22817 0.67657   1.000 19.13209 ? 28  TRP A CE2  1 
ATOM   552  C  CE3  . TRP A 1 28  ? 5.29939   -23.25461 0.28801   1.000 20.95239 ? 28  TRP A CE3  1 
ATOM   553  C  CZ2  . TRP A 1 28  ? 7.28277   -24.20257 2.05558   1.000 21.22032 ? 28  TRP A CZ2  1 
ATOM   554  C  CZ3  . TRP A 1 28  ? 5.10828   -23.25536 1.64922   1.000 22.96527 ? 28  TRP A CZ3  1 
ATOM   555  C  CH2  . TRP A 1 28  ? 6.09415   -23.70860 2.51698   1.000 24.54752 ? 28  TRP A CH2  1 
ATOM   556  H  H    . TRP A 1 28  ? 6.84948   -25.78346 -3.57654  1.000 21.53167 ? 28  TRP A H    1 
ATOM   557  H  HA   . TRP A 1 28  ? 4.66909   -24.72181 -2.52528  1.000 21.70754 ? 28  TRP A HA   1 
ATOM   558  H  HB2  . TRP A 1 28  ? 7.00774   -23.47269 -3.51252  1.000 22.47002 ? 28  TRP A HB2  1 
ATOM   559  H  HB3  . TRP A 1 28  ? 5.88878   -22.70868 -2.68209  1.000 22.47002 ? 28  TRP A HB3  1 
ATOM   560  H  HD1  . TRP A 1 28  ? 8.86625   -24.63657 -2.09818  1.000 25.15632 ? 28  TRP A HD1  1 
ATOM   561  H  HE1  . TRP A 1 28  ? 9.29800   -24.94541 0.25204   1.000 24.91979 ? 28  TRP A HE1  1 
ATOM   562  H  HE3  . TRP A 1 28  ? 4.64352   -22.92564 -0.28341  1.000 25.14351 ? 28  TRP A HE3  1 
ATOM   563  H  HZ2  . TRP A 1 28  ? 7.93603   -24.51057 2.64149   1.000 25.46502 ? 28  TRP A HZ2  1 
ATOM   564  H  HZ3  . TRP A 1 28  ? 4.30278   -22.94622 1.99636   1.000 27.55897 ? 28  TRP A HZ3  1 
ATOM   565  H  HH2  . TRP A 1 28  ? 5.94194   -23.67522 3.43383   1.000 29.45766 ? 28  TRP A HH2  1 
ATOM   566  N  N    . VAL A 1 29  ? 5.07901   -24.30805 -5.65198  1.000 16.96935 ? 29  VAL A N    1 
ATOM   567  C  CA   . VAL A 1 29  ? 4.38555   -23.93575 -6.86465  1.000 16.68466 ? 29  VAL A CA   1 
ATOM   568  C  C    . VAL A 1 29  ? 3.16124   -24.81819 -7.06135  1.000 18.36357 ? 29  VAL A C    1 
ATOM   569  O  O    . VAL A 1 29  ? 2.09099   -24.34741 -7.45346  1.000 18.37255 ? 29  VAL A O    1 
ATOM   570  C  CB   . VAL A 1 29  ? 5.36746   -23.98060 -8.06156  1.000 18.34802 ? 29  VAL A CB   1 
ATOM   571  C  CG1  . VAL A 1 29  ? 4.64613   -23.71352 -9.36678  1.000 20.73553 ? 29  VAL A CG1  1 
ATOM   572  C  CG2  . VAL A 1 29  ? 6.47660   -22.97095 -7.87194  1.000 20.03735 ? 29  VAL A CG2  1 
ATOM   573  H  H    . VAL A 1 29  ? 5.85877   -24.64649 -5.78247  1.000 20.36386 ? 29  VAL A H    1 
ATOM   574  H  HA   . VAL A 1 29  ? 4.06483   -23.02329 -6.79078  1.000 20.02223 ? 29  VAL A HA   1 
ATOM   575  H  HB   . VAL A 1 29  ? 5.75477   -24.86889 -8.10427  1.000 22.01826 ? 29  VAL A HB   1 
ATOM   576  H  HG11 . VAL A 1 29  ? 5.29907   -23.65094 -10.08138 1.000 24.88327 ? 29  VAL A HG11 1 
ATOM   577  H  HG12 . VAL A 1 29  ? 4.03171   -24.44311 -9.54308  1.000 24.88327 ? 29  VAL A HG12 1 
ATOM   578  H  HG13 . VAL A 1 29  ? 4.15653   -22.87948 -9.29210  1.000 24.88327 ? 29  VAL A HG13 1 
ATOM   579  H  HG21 . VAL A 1 29  ? 7.13837   -23.09388 -8.57040  1.000 24.04546 ? 29  VAL A HG21 1 
ATOM   580  H  HG22 . VAL A 1 29  ? 6.10263   -22.07746 -7.92414  1.000 24.04546 ? 29  VAL A HG22 1 
ATOM   581  H  HG23 . VAL A 1 29  ? 6.88387   -23.10880 -7.00243  1.000 24.04546 ? 29  VAL A HG23 1 
ATOM   582  N  N    . CYS A 1 30  ? 3.30534   -26.12411 -6.85461  1.000 16.62452 ? 30  CYS A N    1 
ATOM   583  C  CA   . CYS A 1 30  ? 2.18183   -27.02978 -6.97099  1.000 15.78255 ? 30  CYS A CA   1 
ATOM   584  C  C    . CYS A 1 30  ? 1.07126   -26.66280 -5.97530  1.000 16.92273 ? 30  CYS A C    1 
ATOM   585  O  O    . CYS A 1 30  ? -0.10906  -26.63849 -6.33641  1.000 17.53518 ? 30  CYS A O    1 
ATOM   586  C  CB   . CYS A 1 30  ? 2.67110   -28.46608 -6.72455  1.000 17.82042 ? 30  CYS A CB   1 
ATOM   587  S  SG   . CYS A 1 30  ? 1.44442   -29.74449 -6.94344  1.000 18.68741 ? 30  CYS A SG   1 
ATOM   588  H  H    . CYS A 1 30  ? 4.04633   -26.50733 -6.64561  1.000 19.95007 ? 30  CYS A H    1 
ATOM   589  H  HA   . CYS A 1 30  ? 1.80990   -26.97423 -7.86512  1.000 18.93971 ? 30  CYS A HA   1 
ATOM   590  H  HB2  . CYS A 1 30  ? 3.39513   -28.65180 -7.34276  1.000 21.38515 ? 30  CYS A HB2  1 
ATOM   591  H  HB3  . CYS A 1 30  ? 2.99125   -28.52654 -5.81090  1.000 21.38515 ? 30  CYS A HB3  1 
ATOM   592  N  N    . ALA A 1 31  ? 1.45082   -26.35055 -4.73781  1.000 16.29489 ? 31  ALA A N    1 
ATOM   593  C  CA   . ALA A 1 31  ? 0.43829   -25.97507 -3.74149  1.000 17.92497 ? 31  ALA A CA   1 
ATOM   594  C  C    . ALA A 1 31  ? -0.30267  -24.72158 -4.17746  1.000 17.25773 ? 31  ALA A C    1 
ATOM   595  O  O    . ALA A 1 31  ? -1.54072  -24.66052 -4.10666  1.000 19.70478 ? 31  ALA A O    1 
ATOM   596  C  CB   . ALA A 1 31  ? 1.05806   -25.74117 -2.37037  1.000 19.01567 ? 31  ALA A CB   1 
ATOM   597  H  H    . ALA A 1 31  ? 2.26231   -26.34688 -4.45309  1.000 19.55450 ? 31  ALA A H    1 
ATOM   598  H  HA   . ALA A 1 31  ? -0.18348  -26.71516 -3.66033  1.000 21.51060 ? 31  ALA A HA   1 
ATOM   599  H  HB1  . ALA A 1 31  ? 0.37237   -25.41889 -1.76467  1.000 22.81945 ? 31  ALA A HB1  1 
ATOM   600  H  HB2  . ALA A 1 31  ? 1.42296   -26.57774 -2.04187  1.000 22.81945 ? 31  ALA A HB2  1 
ATOM   601  H  HB3  . ALA A 1 31  ? 1.76445   -25.08137 -2.45149  1.000 22.81945 ? 31  ALA A HB3  1 
ATOM   602  N  N    . ALA A 1 32  ? 0.43232   -23.72324 -4.66989  1.000 16.81582 ? 32  ALA A N    1 
ATOM   603  C  CA   . ALA A 1 32  ? -0.20301  -22.48202 -5.10641  1.000 15.80756 ? 32  ALA A CA   1 
ATOM   604  C  C    . ALA A 1 32  ? -1.13499  -22.71109 -6.29506  1.000 17.74056 ? 32  ALA A C    1 
ATOM   605  O  O    . ALA A 1 32  ? -2.21042  -22.09825 -6.37166  1.000 19.06869 ? 32  ALA A O    1 
ATOM   606  C  CB   . ALA A 1 32  ? 0.86779   -21.44512 -5.46265  1.000 17.42660 ? 32  ALA A CB   1 
ATOM   607  H  H    . ALA A 1 32  ? 1.28740   -23.73910 -4.76036  1.000 20.17962 ? 32  ALA A H    1 
ATOM   608  H  HA   . ALA A 1 32  ? -0.73605  -22.13559 -4.37377  1.000 18.96971 ? 32  ALA A HA   1 
ATOM   609  H  HB1  . ALA A 1 32  ? 0.43747   -20.66744 -5.85116  1.000 20.91256 ? 32  ALA A HB1  1 
ATOM   610  H  HB2  . ALA A 1 32  ? 1.34285   -21.19175 -4.65579  1.000 20.91256 ? 32  ALA A HB2  1 
ATOM   611  H  HB3  . ALA A 1 32  ? 1.48502   -21.83517 -6.10124  1.000 20.91256 ? 32  ALA A HB3  1 
ATOM   612  N  N    . LYS A 1 33  ? -0.75987  -23.57073 -7.24616  1.000 16.99308 ? 33  LYS A N    1 
ATOM   613  C  CA   . LYS A 1 33  ? -1.63247  -23.83581 -8.38161  1.000 17.42306 ? 33  LYS A CA   1 
ATOM   614  C  C    . LYS A 1 33  ? -2.97044  -24.38140 -7.91942  1.000 17.46315 ? 33  LYS A C    1 
ATOM   615  O  O    . LYS A 1 33  ? -4.03442  -23.89590 -8.33208  1.000 18.75109 ? 33  LYS A O    1 
ATOM   616  C  CB   . LYS A 1 33  ? -0.97043  -24.85707 -9.31061  1.000 21.75618 ? 33  LYS A CB   1 
ATOM   617  C  CG   . LYS A 1 33  ? -1.89638  -25.42891 -10.40855 1.000 22.60154 ? 33  LYS A CG   1 
ATOM   618  C  CD   . LYS A 1 33  ? -2.14469  -24.40775 -11.47548 1.000 29.54190 ? 33  LYS A CD   1 
ATOM   619  C  CE   . LYS A 1 33  ? -3.15041  -24.92314 -12.49794 1.000 43.13243 ? 33  LYS A CE   1 
ATOM   620  N  NZ   . LYS A 1 33  ? -3.43334  -23.89722 -13.54085 1.000 46.42455 ? 33  LYS A NZ   1 
ATOM   621  H  H    . LYS A 1 33  ? -0.01719  -24.00427 -7.25416  1.000 20.39234 ? 33  LYS A H    1 
ATOM   622  H  HA   . LYS A 1 33  ? -1.77566  -23.00624 -8.86348  1.000 20.90831 ? 33  LYS A HA   1 
ATOM   623  H  HB2  . LYS A 1 33  ? -0.22118  -24.42955 -9.75416  1.000 26.10806 ? 33  LYS A HB2  1 
ATOM   624  H  HB3  . LYS A 1 33  ? -0.65741  -25.60288 -8.77517  1.000 26.10806 ? 33  LYS A HB3  1 
ATOM   625  H  HG2  . LYS A 1 33  ? -1.47767  -26.20381 -10.81489 1.000 27.12249 ? 33  LYS A HG2  1 
ATOM   626  H  HG3  . LYS A 1 33  ? -2.74786  -25.67903 -10.01700 1.000 27.12249 ? 33  LYS A HG3  1 
ATOM   627  H  HD2  . LYS A 1 33  ? -2.50132  -23.60012 -11.07368 1.000 35.45092 ? 33  LYS A HD2  1 
ATOM   628  H  HD3  . LYS A 1 33  ? -1.31324  -24.21067 -11.93455 1.000 35.45092 ? 33  LYS A HD3  1 
ATOM   629  H  HE2  . LYS A 1 33  ? -2.79136  -25.71184 -12.93375 1.000 51.75956 ? 33  LYS A HE2  1 
ATOM   630  H  HE3  . LYS A 1 33  ? -3.98241  -25.14158 -12.04965 1.000 51.75956 ? 33  LYS A HE3  1 
ATOM   631  H  HZ1  . LYS A 1 33  ? -3.76221  -23.16161 -13.16292 1.000 55.71010 ? 33  LYS A HZ1  1 
ATOM   632  H  HZ2  . LYS A 1 33  ? -2.68437  -23.68915 -13.97427 1.000 55.71010 ? 33  LYS A HZ2  1 
ATOM   633  H  HZ3  . LYS A 1 33  ? -4.02685  -24.21213 -14.12453 1.000 55.71010 ? 33  LYS A HZ3  1 
ATOM   634  N  N    . PHE A 1 34  ? -2.95227  -25.37386 -7.03121  1.000 17.66808 ? 34  PHE A N    1 
ATOM   635  C  CA   . PHE A 1 34  ? -4.20942  -25.99094 -6.66050  1.000 17.62579 ? 34  PHE A CA   1 
ATOM   636  C  C    . PHE A 1 34  ? -4.93542  -25.28444 -5.53698  1.000 18.69656 ? 34  PHE A C    1 
ATOM   637  O  O    . PHE A 1 34  ? -6.16324  -25.44154 -5.44161  1.000 22.42344 ? 34  PHE A O    1 
ATOM   638  C  CB   . PHE A 1 34  ? -4.01194  -27.45728 -6.37216  1.000 19.10463 ? 34  PHE A CB   1 
ATOM   639  C  CG   . PHE A 1 34  ? -3.54055  -28.24095 -7.56725  1.000 18.02379 ? 34  PHE A CG   1 
ATOM   640  C  CD1  . PHE A 1 34  ? -4.26692  -28.24659 -8.72476  1.000 20.02637 ? 34  PHE A CD1  1 
ATOM   641  C  CD2  . PHE A 1 34  ? -2.33325  -28.89327 -7.54986  1.000 23.23157 ? 34  PHE A CD2  1 
ATOM   642  C  CE1  . PHE A 1 34  ? -3.82841  -28.94836 -9.82433  1.000 24.40660 ? 34  PHE A CE1  1 
ATOM   643  C  CE2  . PHE A 1 34  ? -1.90980  -29.61407 -8.65377  1.000 29.65729 ? 34  PHE A CE2  1 
ATOM   644  C  CZ   . PHE A 1 34  ? -2.64690  -29.61754 -9.77161  1.000 24.93172 ? 34  PHE A CZ   1 
ATOM   645  H  H    . PHE A 1 34  ? -2.25027  -25.69037 -6.64830  1.000 21.20234 ? 34  PHE A H    1 
ATOM   646  H  HA   . PHE A 1 34  ? -4.81389  -25.94818 -7.41791  1.000 21.15159 ? 34  PHE A HA   1 
ATOM   647  H  HB2  . PHE A 1 34  ? -3.34709  -27.55251 -5.67230  1.000 22.92620 ? 34  PHE A HB2  1 
ATOM   648  H  HB3  . PHE A 1 34  ? -4.85622  -27.83622 -6.08151  1.000 22.92620 ? 34  PHE A HB3  1 
ATOM   649  H  HD1  . PHE A 1 34  ? -5.06522  -27.77163 -8.76985  1.000 24.03228 ? 34  PHE A HD1  1 
ATOM   650  H  HD2  . PHE A 1 34  ? -1.79608  -28.85095 -6.79186  1.000 27.87852 ? 34  PHE A HD2  1 
ATOM   651  H  HE1  . PHE A 1 34  ? -4.33925  -28.96459 -10.60130 1.000 29.28857 ? 34  PHE A HE1  1 
ATOM   652  H  HE2  . PHE A 1 34  ? -1.11461  -30.09506 -8.61882  1.000 35.58939 ? 34  PHE A HE2  1 
ATOM   653  H  HZ   . PHE A 1 34  ? -2.34731  -30.08249 -10.51925 1.000 29.91870 ? 34  PHE A HZ   1 
ATOM   654  N  N    . GLU A 1 35  ? -4.25696  -24.46173 -4.74211  1.000 16.88458 ? 35  GLU A N    1 
ATOM   655  C  CA   . GLU A 1 35  ? -4.97994  -23.65756 -3.74219  1.000 17.17590 ? 35  GLU A CA   1 
ATOM   656  C  C    . GLU A 1 35  ? -5.68377  -22.45031 -4.37105  1.000 19.19532 ? 35  GLU A C    1 
ATOM   657  O  O    . GLU A 1 35  ? -6.82406  -22.13549 -4.00546  1.000 19.77394 ? 35  GLU A O    1 
ATOM   658  C  CB   . GLU A 1 35  ? -4.00235  -23.21122 -2.66160  1.000 17.83505 ? 35  GLU A CB   1 
ATOM   659  C  CG   . GLU A 1 35  ? -3.49859  -24.32921 -1.78446  1.000 18.91926 ? 35  GLU A CG   1 
ATOM   660  C  CD   . GLU A 1 35  ? -4.54027  -24.84574 -0.82746  1.000 21.97031 ? 35  GLU A CD   1 
ATOM   661  O  OE1  . GLU A 1 35  ? -5.67368  -24.30976 -0.77360  1.000 22.56896 ? 35  GLU A OE1  1 
ATOM   662  O  OE2  . GLU A 1 35  ? -4.26875  -25.88970 -0.20674  1.000 22.33425 ? 35  GLU A OE2  1 
ATOM   663  H  H    . GLU A 1 35  ? -3.40448  -24.34905 -4.75541  1.000 20.26213 ? 35  GLU A H    1 
ATOM   664  H  HA   . GLU A 1 35  ? -5.66817  -24.20395 -3.33146  1.000 20.61172 ? 35  GLU A HA   1 
ATOM   665  H  HB2  . GLU A 1 35  ? -3.23316  -22.80285 -3.08876  1.000 21.40270 ? 35  GLU A HB2  1 
ATOM   666  H  HB3  . GLU A 1 35  ? -4.44593  -22.56545 -2.08965  1.000 21.40270 ? 35  GLU A HB3  1 
ATOM   667  H  HG2  . GLU A 1 35  ? -3.21753  -25.06799 -2.34671  1.000 22.70375 ? 35  GLU A HG2  1 
ATOM   668  H  HG3  . GLU A 1 35  ? -2.74800  -24.00554 -1.26219  1.000 22.70375 ? 35  GLU A HG3  1 
ATOM   669  N  N    . SER A 1 36  ? -5.04479  -21.75649 -5.31348  1.000 17.93972 ? 36  SER A N    1 
ATOM   670  C  CA   . SER A 1 36  ? -5.51233  -20.45498 -5.78267  1.000 16.46169 ? 36  SER A CA   1 
ATOM   671  C  C    . SER A 1 36  ? -5.48584  -20.27394 -7.29675  1.000 19.60835 ? 36  SER A C    1 
ATOM   672  O  O    . SER A 1 36  ? -5.85171  -19.17814 -7.75774  1.000 20.46273 ? 36  SER A O    1 
ATOM   673  C  CB   . SER A 1 36  ? -4.63315  -19.36905 -5.18131  1.000 18.47578 ? 36  SER A CB   1 
ATOM   674  O  OG   . SER A 1 36  ? -3.32755  -19.39961 -5.74829  1.000 19.14481 ? 36  SER A OG   1 
ATOM   675  H  H    . SER A 1 36  ? -4.32592  -22.02318 -5.70298  1.000 21.52830 ? 36  SER A H    1 
ATOM   676  H  HA   . SER A 1 36  ? -6.43173  -20.34686 -5.49299  1.000 19.75467 ? 36  SER A HA   1 
ATOM   677  H  HB2  . SER A 1 36  ? -5.03418  -18.50396 -5.35938  1.000 22.17157 ? 36  SER A HB2  1 
ATOM   678  H  HB3  . SER A 1 36  ? -4.56489  -19.51243 -4.22439  1.000 22.17157 ? 36  SER A HB3  1 
ATOM   679  H  HG   . SER A 1 36  ? -2.93751  -20.11178 -5.53317  1.000 22.97441 ? 36  SER A HG   1 
ATOM   680  N  N    . ASN A 1 37  ? -5.02358  -21.25150 -8.07342  1.000 19.46601 ? 37  ASN A N    1 
ATOM   681  C  CA   . ASN A 1 37  ? -4.78460  -21.09631 -9.50566  1.000 20.52933 ? 37  ASN A CA   1 
ATOM   682  C  C    . ASN A 1 37  ? -3.85938  -19.92495 -9.78791  1.000 18.93182 ? 37  ASN A C    1 
ATOM   683  O  O    . ASN A 1 37  ? -3.99091  -19.22133 -10.79294 1.000 22.08994 ? 37  ASN A O    1 
ATOM   684  C  CB   . ASN A 1 37  ? -6.08724  -20.98835 -10.30085 1.000 24.05959 ? 37  ASN A CB   1 
ATOM   685  C  CG   . ASN A 1 37  ? -5.97061  -21.58180 -11.66914 1.000 37.99285 ? 37  ASN A CG   1 
ATOM   686  O  OD1  . ASN A 1 37  ? -4.95246  -22.17111 -12.01682 1.000 32.87890 ? 37  ASN A OD1  1 
ATOM   687  N  ND2  . ASN A 1 37  ? -7.01678  -21.42265 -12.46844 1.000 57.00746 ? 37  ASN A ND2  1 
ATOM   688  H  H    . ASN A 1 37  ? -4.83470  -22.03930 -7.78481  1.000 23.35986 ? 37  ASN A H    1 
ATOM   689  H  HA   . ASN A 1 37  ? -4.33696  -21.89735 -9.82006  1.000 24.63584 ? 37  ASN A HA   1 
ATOM   690  H  HB2  . ASN A 1 37  ? -6.78903  -21.46068 -9.82620  1.000 28.87215 ? 37  ASN A HB2  1 
ATOM   691  H  HB3  . ASN A 1 37  ? -6.32372  -20.05257 -10.39727 1.000 28.87215 ? 37  ASN A HB3  1 
ATOM   692  H  HD21 . ASN A 1 37  ? -7.71037  -20.99758 -12.18942 1.000 68.40959 ? 37  ASN A HD21 1 
ATOM   693  H  HD22 . ASN A 1 37  ? -7.00162  -21.74450 -13.26579 1.000 68.40959 ? 37  ASN A HD22 1 
ATOM   694  N  N    . PHE A 1 38  ? -2.93072  -19.68485 -8.87999  1.000 18.48731 ? 38  PHE A N    1 
ATOM   695  C  CA   . PHE A 1 38  ? -1.90188  -18.65304 -8.97872  1.000 18.30073 ? 38  PHE A CA   1 
ATOM   696  C  C    . PHE A 1 38  ? -2.44190  -17.22845 -8.86926  1.000 18.52475 ? 38  PHE A C    1 
ATOM   697  O  O    . PHE A 1 38  ? -1.76214  -16.27640 -9.24863  1.000 20.43106 ? 38  PHE A O    1 
ATOM   698  C  CB   . PHE A 1 38  ? -1.04801  -18.74365 -10.25554 1.000 19.38213 ? 38  PHE A CB   1 
ATOM   699  C  CG   . PHE A 1 38  ? -0.28877  -20.04268 -10.45169 1.000 19.45231 ? 38  PHE A CG   1 
ATOM   700  C  CD1  . PHE A 1 38  ? 0.33812   -20.69670 -9.42547  1.000 19.35070 ? 38  PHE A CD1  1 
ATOM   701  C  CD2  . PHE A 1 38  ? -0.13039  -20.53046 -11.71909 1.000 21.84321 ? 38  PHE A CD2  1 
ATOM   702  C  CE1  . PHE A 1 38  ? 1.08199   -21.86355 -9.66130  1.000 21.18918 ? 38  PHE A CE1  1 
ATOM   703  C  CE2  . PHE A 1 38  ? 0.62030   -21.68692 -11.96456 1.000 21.67926 ? 38  PHE A CE2  1 
ATOM   704  C  CZ   . PHE A 1 38  ? 1.20169   -22.33761 -10.93305 1.000 22.68877 ? 38  PHE A CZ   1 
ATOM   705  H  H    . PHE A 1 38  ? -2.86845  -20.13340 -8.14888  1.000 22.18541 ? 38  PHE A H    1 
ATOM   706  H  HA   . PHE A 1 38  ? -1.32002  -18.82009 -8.22081  1.000 21.96152 ? 38  PHE A HA   1 
ATOM   707  H  HB2  . PHE A 1 38  ? -1.63361  -18.63478 -11.02112 1.000 23.25920 ? 38  PHE A HB2  1 
ATOM   708  H  HB3  . PHE A 1 38  ? -0.39303  -18.02848 -10.23450 1.000 23.25920 ? 38  PHE A HB3  1 
ATOM   709  H  HD1  . PHE A 1 38  ? 0.27025   -20.36332 -8.55993  1.000 23.22148 ? 38  PHE A HD1  1 
ATOM   710  H  HD2  . PHE A 1 38  ? -0.52891  -20.08564 -12.43199 1.000 26.21250 ? 38  PHE A HD2  1 
ATOM   711  H  HE1  . PHE A 1 38  ? 1.49010   -22.30973 -8.95471  1.000 25.42766 ? 38  PHE A HE1  1 
ATOM   712  H  HE2  . PHE A 1 38  ? 0.71810   -22.00527 -12.83288 1.000 26.01575 ? 38  PHE A HE2  1 
ATOM   713  H  HZ   . PHE A 1 38  ? 1.68711   -23.11474 -11.09224 1.000 27.22716 ? 38  PHE A HZ   1 
ATOM   714  N  N    . ASN A 1 39  ? -3.64122  -17.07018 -8.32556  1.000 19.05311 ? 39  ASN A N    1 
ATOM   715  C  CA   . ASN A 1 39  ? -4.29343  -15.75556 -8.18668  1.000 17.56694 ? 39  ASN A CA   1 
ATOM   716  C  C    . ASN A 1 39  ? -4.14572  -15.22631 -6.76685  1.000 17.81629 ? 39  ASN A C    1 
ATOM   717  O  O    . ASN A 1 39  ? -4.68452  -15.81021 -5.81395  1.000 19.21223 ? 39  ASN A O    1 
ATOM   718  C  CB   . ASN A 1 39  ? -5.76565  -15.92382 -8.55156  1.000 19.19155 ? 39  ASN A CB   1 
ATOM   719  C  CG   . ASN A 1 39  ? -6.54358  -14.64779 -8.53840  1.000 19.15777 ? 39  ASN A CG   1 
ATOM   720  O  OD1  . ASN A 1 39  ? -6.02616  -13.59705 -8.30706  1.000 19.72372 ? 39  ASN A OD1  1 
ATOM   721  N  ND2  . ASN A 1 39  ? -7.81073  -14.76003 -8.84528  1.000 26.45996 ? 39  ASN A ND2  1 
ATOM   722  H  H    . ASN A 1 39  ? -4.11539  -17.71922 -8.01979  1.000 22.86437 ? 39  ASN A H    1 
ATOM   723  H  HA   . ASN A 1 39  ? -3.86642  -15.10314 -8.76367  1.000 21.08096 ? 39  ASN A HA   1 
ATOM   724  H  HB2  . ASN A 1 39  ? -5.82448  -16.29582 -9.44546  1.000 23.03050 ? 39  ASN A HB2  1 
ATOM   725  H  HB3  . ASN A 1 39  ? -6.17777  -16.52700 -7.91341  1.000 23.03050 ? 39  ASN A HB3  1 
ATOM   726  H  HD21 . ASN A 1 39  ? -8.31397  -14.06272 -8.85597  1.000 31.75259 ? 39  ASN A HD21 1 
ATOM   727  H  HD22 . ASN A 1 39  ? -8.14025  -15.53109 -9.03626  1.000 31.75259 ? 39  ASN A HD22 1 
ATOM   728  N  N    . THR A 1 40  ? -3.45512  -14.10587 -6.61126  1.000 17.93879 ? 40  THR A N    1 
ATOM   729  C  CA   . THR A 1 40  ? -3.27050  -13.53850 -5.29178  1.000 19.36583 ? 40  THR A CA   1 
ATOM   730  C  C    . THR A 1 40  ? -4.58605  -13.06585 -4.66414  1.000 19.50230 ? 40  THR A C    1 
ATOM   731  O  O    . THR A 1 40  ? -4.63290  -12.93078 -3.44611  1.000 20.37828 ? 40  THR A O    1 
ATOM   732  C  CB   . THR A 1 40  ? -2.31088  -12.35136 -5.29651  1.000 19.07759 ? 40  THR A CB   1 
ATOM   733  O  OG1  . THR A 1 40  ? -2.89389  -11.27819 -6.05945  1.000 20.77131 ? 40  THR A OG1  1 
ATOM   734  C  CG2  . THR A 1 40  ? -0.91892  -12.68542 -5.86400  1.000 20.81244 ? 40  THR A CG2  1 
ATOM   735  H  H    . THR A 1 40  ? -3.08778  -13.66091 -7.24897  1.000 21.52719 ? 40  THR A H    1 
ATOM   736  H  HA   . THR A 1 40  ? -2.87662  -14.24140 -4.75169  1.000 23.23963 ? 40  THR A HA   1 
ATOM   737  H  HB   . THR A 1 40  ? -2.16676  -12.08316 -4.37553  1.000 22.89374 ? 40  THR A HB   1 
ATOM   738  H  HG1  . THR A 1 40  ? -2.58658  -10.54091 -5.79948  1.000 24.92621 ? 40  THR A HG1  1 
ATOM   739  H  HG21 . THR A 1 40  ? -0.28116  -12.00335 -5.60141  1.000 24.97557 ? 40  THR A HG21 1 
ATOM   740  H  HG22 . THR A 1 40  ? -0.61960  -13.54352 -5.52492  1.000 24.97557 ? 40  THR A HG22 1 
ATOM   741  H  HG23 . THR A 1 40  ? -0.95631  -12.72530 -6.83246  1.000 24.97557 ? 40  THR A HG23 1 
ATOM   742  N  N    A GLN A 1 41  ? -5.62476  -12.83042 -5.46056  0.541 18.01382 ? 41  GLN A N    1 
ATOM   743  N  N    B GLN A 1 41  ? -5.64423  -12.81259 -5.43779  0.459 18.05922 ? 41  GLN A N    1 
ATOM   744  C  CA   A GLN A 1 41  ? -6.86934  -12.29848 -4.92553  0.541 16.94623 ? 41  GLN A CA   1 
ATOM   745  C  CA   B GLN A 1 41  ? -6.89252  -12.30421 -4.86457  0.459 16.88224 ? 41  GLN A CA   1 
ATOM   746  C  C    A GLN A 1 41  ? -7.82102  -13.35778 -4.40200  0.541 17.54048 ? 41  GLN A C    1 
ATOM   747  C  C    B GLN A 1 41  ? -7.92142  -13.40319 -4.57903  0.459 19.12038 ? 41  GLN A C    1 
ATOM   748  O  O    A GLN A 1 41  ? -8.86185  -12.97810 -3.83636  0.541 19.32437 ? 41  GLN A O    1 
ATOM   749  O  O    B GLN A 1 41  ? -9.11294  -13.12021 -4.36528  0.459 18.54637 ? 41  GLN A O    1 
ATOM   750  C  CB   A GLN A 1 41  ? -7.60265  -11.46799 -5.98257  0.541 19.57328 ? 41  GLN A CB   1 
ATOM   751  C  CB   B GLN A 1 41  ? -7.47649  -11.19707 -5.74482  0.459 15.72145 ? 41  GLN A CB   1 
ATOM   752  C  CG   A GLN A 1 41  ? -6.81117  -10.28458 -6.45518  0.541 18.39216 ? 41  GLN A CG   1 
ATOM   753  C  CG   B GLN A 1 41  ? -6.54512  -10.03197 -5.97784  0.459 19.78689 ? 41  GLN A CG   1 
ATOM   754  C  CD   A GLN A 1 41  ? -7.69631  -9.23005  -7.09812  0.541 19.93543 ? 41  GLN A CD   1 
ATOM   755  C  CD   B GLN A 1 41  ? -7.24383  -8.84412  -6.63799  0.459 18.15339 ? 41  GLN A CD   1 
ATOM   756  O  OE1  A GLN A 1 41  ? -8.51916  -8.61030  -6.43064  0.541 17.51785 ? 41  GLN A OE1  1 
ATOM   757  O  OE1  B GLN A 1 41  ? -7.82984  -8.01812  -5.96632  0.459 22.05932 ? 41  GLN A OE1  1 
ATOM   758  N  NE2  A GLN A 1 41  ? -7.54744  -9.04214  -8.39895  0.541 19.42379 ? 41  GLN A NE2  1 
ATOM   759  N  NE2  B GLN A 1 41  ? -7.18364  -8.77245  -7.96211  0.459 17.05300 ? 41  GLN A NE2  1 
ATOM   760  H  H    A GLN A 1 41  ? -5.63130  -12.97043 -6.30906  0.541 21.61722 ? 41  GLN A H    1 
ATOM   761  H  H    B GLN A 1 41  ? -5.66274  -12.92648 -6.29001  0.459 21.67171 ? 41  GLN A H    1 
ATOM   762  H  HA   A GLN A 1 41  ? -6.63654  -11.71649 -4.18527  0.541 20.33611 ? 41  GLN A HA   1 
ATOM   763  H  HA   B GLN A 1 41  ? -6.68529  -11.90175 -4.00668  0.459 20.25933 ? 41  GLN A HA   1 
ATOM   764  H  HB2  A GLN A 1 41  ? -7.78754  -12.03009 -6.75118  0.541 23.48858 ? 41  GLN A HB2  1 
ATOM   765  H  HB2  B GLN A 1 41  ? -7.69757  -11.57418 -6.61074  0.459 18.86638 ? 41  GLN A HB2  1 
ATOM   766  H  HB3  A GLN A 1 41  ? -8.43329  -11.14004 -5.60391  0.541 23.48858 ? 41  GLN A HB3  1 
ATOM   767  H  HB3  B GLN A 1 41  ? -8.27698  -10.85263 -5.31882  0.459 18.86638 ? 41  GLN A HB3  1 
ATOM   768  H  HG2  A GLN A 1 41  ? -6.35845  -9.88045  -5.69846  0.541 22.07124 ? 41  GLN A HG2  1 
ATOM   769  H  HG2  B GLN A 1 41  ? -6.18932  -9.73562  -5.12550  0.459 23.74491 ? 41  GLN A HG2  1 
ATOM   770  H  HG3  A GLN A 1 41  ? -6.16116  -10.57729 -7.11299  0.541 22.07124 ? 41  GLN A HG3  1 
ATOM   771  H  HG3  B GLN A 1 41  ? -5.82191  -10.31594 -6.55856  0.459 23.74491 ? 41  GLN A HG3  1 
ATOM   772  H  HE21 A GLN A 1 41  ? -8.02678  -8.45573  -8.80634  0.541 23.30919 ? 41  GLN A HE21 1 
ATOM   773  H  HE21 B GLN A 1 41  ? -7.56308  -8.12050  -8.37514  0.459 20.46424 ? 41  GLN A HE21 1 
ATOM   774  H  HE22 A GLN A 1 41  ? -6.97132  -9.50637  -8.83732  0.541 23.30919 ? 41  GLN A HE22 1 
ATOM   775  H  HE22 B GLN A 1 41  ? -6.76521  -9.37796  -8.40694  0.459 20.46424 ? 41  GLN A HE22 1 
ATOM   776  N  N    . ALA A 1 42  ? -7.50599  -14.65781 -4.58444  1.000 16.81749 ? 42  ALA A N    1 
ATOM   777  C  CA   . ALA A 1 42  ? -8.42556  -15.73278 -4.25608  1.000 18.27946 ? 42  ALA A CA   1 
ATOM   778  C  C    . ALA A 1 42  ? -8.86573  -15.70460 -2.79591  1.000 16.56090 ? 42  ALA A C    1 
ATOM   779  O  O    . ALA A 1 42  ? -8.04766  -15.55632 -1.88865  1.000 18.48703 ? 42  ALA A O    1 
ATOM   780  C  CB   . ALA A 1 42  ? -7.77098  -17.07872 -4.56199  1.000 22.25697 ? 42  ALA A CB   1 
ATOM   781  H  H    . ALA A 1 42  ? -6.75466  -14.93147 -4.90103  1.000 20.18163 ? 42  ALA A H    1 
ATOM   782  H  HA   . ALA A 1 42  ? -9.22211  -15.61830 -4.79767  1.000 21.93599 ? 42  ALA A HA   1 
ATOM   783  H  HB1  . ALA A 1 42  ? -8.40180  -17.78873 -4.36491  1.000 26.70901 ? 42  ALA A HB1  1 
ATOM   784  H  HB2  . ALA A 1 42  ? -7.52610  -17.10481 -5.50021  1.000 26.70901 ? 42  ALA A HB2  1 
ATOM   785  H  HB3  . ALA A 1 42  ? -6.97907  -17.17734 -4.01058  1.000 26.70901 ? 42  ALA A HB3  1 
ATOM   786  N  N    . THR A 1 43  ? -10.16794 -15.87695 -2.59793  1.000 18.33050 ? 43  THR A N    1 
ATOM   787  C  CA   . THR A 1 43  ? -10.75021 -16.05729 -1.27640  1.000 18.29456 ? 43  THR A CA   1 
ATOM   788  C  C    . THR A 1 43  ? -11.74683 -17.19481 -1.32095  1.000 20.58787 ? 43  THR A C    1 
ATOM   789  O  O    . THR A 1 43  ? -12.41264 -17.43701 -2.33307  1.000 24.48126 ? 43  THR A O    1 
ATOM   790  C  CB   . THR A 1 43  ? -11.43042 -14.79418 -0.73216  1.000 20.36389 ? 43  THR A CB   1 
ATOM   791  O  OG1  . THR A 1 43  ? -12.49969 -14.42553 -1.60487  1.000 21.52719 ? 43  THR A OG1  1 
ATOM   792  C  CG2  . THR A 1 43  ? -10.47902 -13.64155 -0.58270  1.000 20.98506 ? 43  THR A CG2  1 
ATOM   793  H  H    . THR A 1 43  ? -10.74910 -15.89340 -3.23163  1.000 21.99724 ? 43  THR A H    1 
ATOM   794  H  HA   . THR A 1 43  ? -10.03858 -16.28113 -0.65642  1.000 21.95411 ? 43  THR A HA   1 
ATOM   795  H  HB   . THR A 1 43  ? -11.77059 -14.98681 0.15558   1.000 24.43731 ? 43  THR A HB   1 
ATOM   796  H  HG1  . THR A 1 43  ? -12.76886 -13.65193 -1.41859  1.000 25.83326 ? 43  THR A HG1  1 
ATOM   797  H  HG21 . THR A 1 43  ? -10.95795 -12.85261 -0.28419  1.000 25.18271 ? 43  THR A HG21 1 
ATOM   798  H  HG22 . THR A 1 43  ? -9.79394  -13.85915 0.06861   1.000 25.18271 ? 43  THR A HG22 1 
ATOM   799  H  HG23 . THR A 1 43  ? -10.05475 -13.44911 -1.43350  1.000 25.18271 ? 43  THR A HG23 1 
ATOM   800  N  N    A ASN A 1 44  ? -11.87052 -17.91551 -0.20568  0.574 18.85880 ? 44  ASN A N    1 
ATOM   801  N  N    B ASN A 1 44  ? -11.86305 -17.89330 -0.19649  0.426 18.86837 ? 44  ASN A N    1 
ATOM   802  C  CA   A ASN A 1 44  ? -12.85978 -18.98843 -0.13085  0.574 18.73338 ? 44  ASN A CA   1 
ATOM   803  C  CA   B ASN A 1 44  ? -12.85384 -18.95027 -0.05993  0.426 18.86578 ? 44  ASN A CA   1 
ATOM   804  C  C    A ASN A 1 44  ? -13.28903 -19.20179 1.31003   0.574 17.40158 ? 44  ASN A C    1 
ATOM   805  C  C    B ASN A 1 44  ? -13.29413 -19.00128 1.39640   0.426 17.69172 ? 44  ASN A C    1 
ATOM   806  O  O    A ASN A 1 44  ? -12.43995 -19.39397 2.18133   0.574 17.52778 ? 44  ASN A O    1 
ATOM   807  O  O    B ASN A 1 44  ? -12.48061 -18.82783 2.30113   0.426 18.55482 ? 44  ASN A O    1 
ATOM   808  C  CB   A ASN A 1 44  ? -12.27790 -20.30787 -0.63663  0.574 22.51606 ? 44  ASN A CB   1 
ATOM   809  C  CB   B ASN A 1 44  ? -12.26473 -20.30158 -0.48303  0.426 22.62607 ? 44  ASN A CB   1 
ATOM   810  C  CG   A ASN A 1 44  ? -12.11231 -20.32955 -2.11982  0.574 20.47636 ? 44  ASN A CG   1 
ATOM   811  C  CG   B ASN A 1 44  ? -13.29886 -21.21591 -1.10524  0.426 34.13232 ? 44  ASN A CG   1 
ATOM   812  O  OD1  A ASN A 1 44  ? -13.08402 -20.36524 -2.87515  0.574 24.62997 ? 44  ASN A OD1  1 
ATOM   813  O  OD1  B ASN A 1 44  ? -14.05636 -21.88328 -0.40826  0.426 38.11873 ? 44  ASN A OD1  1 
ATOM   814  N  ND2  A ASN A 1 44  ? -10.87017 -20.27754 -2.55741  0.574 23.93445 ? 44  ASN A ND2  1 
ATOM   815  N  ND2  B ASN A 1 44  ? -13.34363 -21.23458 -2.42617  0.426 35.14166 ? 44  ASN A ND2  1 
ATOM   816  H  H    A ASN A 1 44  ? -11.40186 -17.80387 0.50671   0.574 22.63119 ? 44  ASN A H    1 
ATOM   817  H  H    B ASN A 1 44  ? -11.37745 -17.77248 0.50294   0.426 22.64269 ? 44  ASN A H    1 
ATOM   818  H  HA   A ASN A 1 44  ? -13.62680 -18.72435 -0.66268  0.574 22.48069 ? 44  ASN A HA   1 
ATOM   819  H  HA   B ASN A 1 44  ? -13.62945 -18.76563 -0.61240  0.426 22.63957 ? 44  ASN A HA   1 
ATOM   820  H  HB2  A ASN A 1 44  ? -11.40575 -20.44433 -0.23460  0.574 27.01991 ? 44  ASN A HB2  1 
ATOM   821  H  HB2  B ASN A 1 44  ? -11.56390 -20.15118 -1.13657  0.426 27.15193 ? 44  ASN A HB2  1 
ATOM   822  H  HB3  A ASN A 1 44  ? -12.87395 -21.03228 -0.38992  0.574 27.01991 ? 44  ASN A HB3  1 
ATOM   823  H  HB3  B ASN A 1 44  ? -11.90021 -20.74691 0.29780   0.426 27.15193 ? 44  ASN A HB3  1 
ATOM   824  H  HD21 A ASN A 1 44  ? -10.21858 -20.23441 -1.99779  0.574 28.72198 ? 44  ASN A HD21 1 
ATOM   825  H  HD21 B ASN A 1 44  ? -12.80346 -20.74437 -2.88170  0.426 42.17063 ? 44  ASN A HD21 1 
ATOM   826  H  HD22 A ASN A 1 44  ? -10.71125 -20.28674 -3.40255  0.574 28.72198 ? 44  ASN A HD22 1 
ATOM   827  H  HD22 B ASN A 1 44  ? -13.91294 -21.73694 -2.83006  0.426 42.17063 ? 44  ASN A HD22 1 
ATOM   828  N  N    A ARG A 1 45  ? -14.60629 -19.20370 1.53179   0.574 21.52079 ? 45  ARG A N    1 
ATOM   829  N  N    B ARG A 1 45  ? -14.58919 -19.21334 1.61160   0.426 21.60199 ? 45  ARG A N    1 
ATOM   830  C  CA   A ARG A 1 45  ? -15.17468 -19.37005 2.86243   0.574 23.50200 ? 45  ARG A CA   1 
ATOM   831  C  CA   B ARG A 1 45  ? -15.16620 -19.25725 2.95058   0.426 23.16794 ? 45  ARG A CA   1 
ATOM   832  C  C    A ARG A 1 45  ? -15.16526 -20.83536 3.27550   0.574 25.40621 ? 45  ARG A C    1 
ATOM   833  C  C    B ARG A 1 45  ? -15.38799 -20.71171 3.34436   0.426 24.66991 ? 45  ARG A C    1 
ATOM   834  O  O    A ARG A 1 45  ? -15.34468 -21.74398 2.45580   0.574 24.46202 ? 45  ARG A O    1 
ATOM   835  O  O    B ARG A 1 45  ? -15.98680 -21.47643 2.57776   0.426 22.75261 ? 45  ARG A O    1 
ATOM   836  C  CB   A ARG A 1 45  ? -16.61171 -18.84918 2.89416   0.574 27.81543 ? 45  ARG A CB   1 
ATOM   837  C  CB   B ARG A 1 45  ? -16.49185 -18.49431 2.99293   0.426 24.49970 ? 45  ARG A CB   1 
ATOM   838  C  CG   A ARG A 1 45  ? -17.25811 -18.92479 4.26629   0.574 28.96529 ? 45  ARG A CG   1 
ATOM   839  C  CG   B ARG A 1 45  ? -17.07602 -18.33808 4.39101   0.426 28.68331 ? 45  ARG A CG   1 
ATOM   840  C  CD   A ARG A 1 45  ? -16.89456 -17.70935 5.08668   0.574 32.16764 ? 45  ARG A CD   1 
ATOM   841  C  CD   B ARG A 1 45  ? -16.67274 -17.01034 5.01031   0.426 29.14946 ? 45  ARG A CD   1 
ATOM   842  N  NE   A ARG A 1 45  ? -17.78737 -16.59453 4.78825   0.574 41.21256 ? 45  ARG A NE   1 
ATOM   843  N  NE   B ARG A 1 45  ? -16.96907 -15.87136 4.14957   0.426 39.24597 ? 45  ARG A NE   1 
ATOM   844  C  CZ   A ARG A 1 45  ? -18.39204 -15.84277 5.69951   0.574 35.55621 ? 45  ARG A CZ   1 
ATOM   845  C  CZ   B ARG A 1 45  ? -18.18938 -15.50427 3.77920   0.426 29.55099 ? 45  ARG A CZ   1 
ATOM   846  N  NH1  A ARG A 1 45  ? -18.12241 -15.96094 6.98793   0.574 29.56479 ? 45  ARG A NH1  1 
ATOM   847  N  NH1  B ARG A 1 45  ? -19.26550 -16.13942 4.21224   0.426 43.13906 ? 45  ARG A NH1  1 
ATOM   848  N  NH2  A ARG A 1 45  ? -19.27258 -14.92983 5.30653   0.574 41.06085 ? 45  ARG A NH2  1 
ATOM   849  N  NH2  B ARG A 1 45  ? -18.33131 -14.48677 2.93870   0.426 41.71448 ? 45  ARG A NH2  1 
ATOM   850  H  H    A ARG A 1 45  ? -15.19829 -19.10857 0.91528   0.574 25.82559 ? 45  ARG A H    1 
ATOM   851  H  H    B ARG A 1 45  ? -15.16490 -19.33699 0.98482   0.426 25.92303 ? 45  ARG A H    1 
ATOM   852  H  HA   A ARG A 1 45  ? -14.64235 -18.86624 3.49781   0.574 28.20304 ? 45  ARG A HA   1 
ATOM   853  H  HA   B ARG A 1 45  ? -14.55868 -18.84824 3.58661   0.426 27.80217 ? 45  ARG A HA   1 
ATOM   854  H  HB2  A ARG A 1 45  ? -16.61290 -17.91969 2.61677   0.574 33.37916 ? 45  ARG A HB2  1 
ATOM   855  H  HB2  B ARG A 1 45  ? -16.34992 -17.60523 2.63197   0.426 29.40028 ? 45  ARG A HB2  1 
ATOM   856  H  HB3  A ARG A 1 45  ? -17.14891 -19.37822 2.28389   0.574 33.37916 ? 45  ARG A HB3  1 
ATOM   857  H  HB3  B ARG A 1 45  ? -17.14187 -18.97141 2.45372   0.426 29.40028 ? 45  ARG A HB3  1 
ATOM   858  H  HG2  A ARG A 1 45  ? -18.22285 -18.95633 4.17043   0.574 34.75899 ? 45  ARG A HG2  1 
ATOM   859  H  HG2  B ARG A 1 45  ? -18.04418 -18.37114 4.34142   0.426 34.42061 ? 45  ARG A HG2  1 
ATOM   860  H  HG3  A ARG A 1 45  ? -16.94480 -19.71672 4.73061   0.574 34.75899 ? 45  ARG A HG3  1 
ATOM   861  H  HG3  B ARG A 1 45  ? -16.74832 -19.05282 4.95904   0.426 34.42061 ? 45  ARG A HG3  1 
ATOM   862  H  HD2  A ARG A 1 45  ? -16.97148 -17.92109 6.03016   0.574 38.60181 ? 45  ARG A HD2  1 
ATOM   863  H  HD2  B ARG A 1 45  ? -17.15590 -16.89024 5.84280   0.426 34.97999 ? 45  ARG A HD2  1 
ATOM   864  H  HD3  A ARG A 1 45  ? -15.98597 -17.43967 4.88019   0.574 38.60181 ? 45  ARG A HD3  1 
ATOM   865  H  HD3  B ARG A 1 45  ? -15.71757 -17.01756 5.17915   0.426 34.97999 ? 45  ARG A HD3  1 
ATOM   866  H  HE   A ARG A 1 45  ? -17.93248 -16.41107 3.96067   0.574 49.45571 ? 45  ARG A HE   1 
ATOM   867  H  HE   B ARG A 1 45  ? -16.30652 -15.40469 3.86171   0.426 47.09581 ? 45  ARG A HE   1 
ATOM   868  H  HH11 A ARG A 1 45  ? -17.54182 -16.53655 7.25472   0.574 35.47839 ? 45  ARG A HH11 1 
ATOM   869  H  HH11 B ARG A 1 45  ? -19.18415 -16.80790 4.74715   0.426 51.76752 ? 45  ARG A HH11 1 
ATOM   870  H  HH12 A ARG A 1 45  ? -18.52756 -15.46222 7.55953   0.574 35.47839 ? 45  ARG A HH12 1 
ATOM   871  H  HH12 B ARG A 1 45  ? -20.04665 -15.88398 3.95894   0.426 51.76752 ? 45  ARG A HH12 1 
ATOM   872  H  HH21 A ARG A 1 45  ? -19.44525 -14.83109 4.46985   0.574 49.27366 ? 45  ARG A HH21 1 
ATOM   873  H  HH21 B ARG A 1 45  ? -17.63752 -14.07463 2.64140   0.426 50.05801 ? 45  ARG A HH21 1 
ATOM   874  H  HH22 A ARG A 1 45  ? -19.67018 -14.43730 5.88870   0.574 49.27366 ? 45  ARG A HH22 1 
ATOM   875  H  HH22 B ARG A 1 45  ? -19.11706 -14.23968 2.69143   0.426 50.05801 ? 45  ARG A HH22 1 
ATOM   876  N  N    . ASN A 1 46  ? -14.95706 -21.05851 4.55942   1.000 22.11319 ? 46  ASN A N    1 
ATOM   877  C  CA   . ASN A 1 46  ? -14.99727 -22.40692 5.14035   1.000 25.29556 ? 46  ASN A CA   1 
ATOM   878  C  C    . ASN A 1 46  ? -16.29789 -22.59045 5.92145   1.000 24.00078 ? 46  ASN A C    1 
ATOM   879  O  O    . ASN A 1 46  ? -16.95931 -21.63210 6.31599   1.000 28.42408 ? 46  ASN A O    1 
ATOM   880  C  CB   . ASN A 1 46  ? -13.82121 -22.63964 6.09572   1.000 27.15818 ? 46  ASN A CB   1 
ATOM   881  C  CG   . ASN A 1 46  ? -12.44985 -22.37980 5.45262   1.000 26.93709 ? 46  ASN A CG   1 
ATOM   882  O  OD1  . ASN A 1 46  ? -11.59374 -21.67034 6.01033   1.000 31.38380 ? 46  ASN A OD1  1 
ATOM   883  N  ND2  . ASN A 1 46  ? -12.23950 -22.95792 4.29544   1.000 30.58611 ? 46  ASN A ND2  1 
ATOM   884  H  H    . ASN A 1 46  ? -14.78682 -20.43984 5.13201   1.000 26.53647 ? 46  ASN A H    1 
ATOM   885  H  HA   . ASN A 1 46  ? -14.94276 -23.05796 4.42336   1.000 30.35531 ? 46  ASN A HA   1 
ATOM   886  H  HB2  . ASN A 1 46  ? -13.91116 -22.04245 6.85478   1.000 32.59045 ? 46  ASN A HB2  1 
ATOM   887  H  HB3  . ASN A 1 46  ? -13.83867 -23.56203 6.39538   1.000 32.59045 ? 46  ASN A HB3  1 
ATOM   888  H  HD21 . ASN A 1 46  ? -11.48939 -22.84737 3.88957   1.000 36.70397 ? 46  ASN A HD21 1 
ATOM   889  H  HD22 . ASN A 1 46  ? -12.85156 -23.44783 3.94194   1.000 36.70397 ? 46  ASN A HD22 1 
ATOM   890  N  N    . THR A 1 47  ? -16.61359 -23.85590 6.20544   1.000 32.55308 ? 47  THR A N    1 
ATOM   891  C  CA   . THR A 1 47  ? -17.87510 -24.17980 6.87612   1.000 38.84752 ? 47  THR A CA   1 
ATOM   892  C  C    . THR A 1 47  ? -17.94755 -23.57392 8.27166   1.000 32.53685 ? 47  THR A C    1 
ATOM   893  O  O    . THR A 1 47  ? -19.03503 -23.17913 8.72365   1.000 37.91103 ? 47  THR A O    1 
ATOM   894  C  CB   . THR A 1 47  ? -18.05457 -25.70543 6.94717   1.000 37.70432 ? 47  THR A CB   1 
ATOM   895  O  OG1  . THR A 1 47  ? -16.92505 -26.30697 7.59304   1.000 49.04313 ? 47  THR A OG1  1 
ATOM   896  C  CG2  . THR A 1 47  ? -18.16737 -26.27226 5.55095   1.000 48.07317 ? 47  THR A CG2  1 
ATOM   897  H  H    . THR A 1 47  ? -16.12199 -24.53764 6.02333   1.000 39.06434 ? 47  THR A H    1 
ATOM   898  H  HA   . THR A 1 47  ? -18.60619 -23.81201 6.35542   1.000 46.61766 ? 47  THR A HA   1 
ATOM   899  H  HB   . THR A 1 47  ? -18.85884 -25.91085 7.44901   1.000 45.24583 ? 47  THR A HB   1 
ATOM   900  H  HG1  . THR A 1 47  ? -17.01528 -27.14192 7.61082   1.000 58.85239 ? 47  THR A HG1  1 
ATOM   901  H  HG21 . THR A 1 47  ? -18.29633 -27.23276 5.59225   1.000 57.68845 ? 47  THR A HG21 1 
ATOM   902  H  HG22 . THR A 1 47  ? -18.92203 -25.87282 5.09070   1.000 57.68845 ? 47  THR A HG22 1 
ATOM   903  H  HG23 . THR A 1 47  ? -17.35804 -26.08454 5.05029   1.000 57.68845 ? 47  THR A HG23 1 
ATOM   904  N  N    A ASP A 1 48  ? -16.81238 -23.48995 8.96605   0.765 30.72268 ? 48  ASP A N    1 
ATOM   905  N  N    B ASP A 1 48  ? -16.81674 -23.48863 8.96987   0.235 30.83487 ? 48  ASP A N    1 
ATOM   906  C  CA   A ASP A 1 48  ? -16.77209 -22.95861 10.32513  0.765 32.54433 ? 48  ASP A CA   1 
ATOM   907  C  CA   B ASP A 1 48  ? -16.79131 -22.95699 10.32786  0.235 32.60238 ? 48  ASP A CA   1 
ATOM   908  C  C    A ASP A 1 48  ? -16.86881 -21.43853 10.38243  0.765 32.97673 ? 48  ASP A C    1 
ATOM   909  C  C    B ASP A 1 48  ? -16.86810 -21.43517 10.38134  0.235 32.97578 ? 48  ASP A C    1 
ATOM   910  O  O    A ASP A 1 48  ? -16.86212 -20.87720 11.48384  0.765 35.81668 ? 48  ASP A O    1 
ATOM   911  O  O    B ASP A 1 48  ? -16.84109 -20.87198 11.48107  0.235 35.65278 ? 48  ASP A O    1 
ATOM   912  C  CB   A ASP A 1 48  ? -15.52999 -23.47435 11.06466  0.765 30.76478 ? 48  ASP A CB   1 
ATOM   913  C  CB   B ASP A 1 48  ? -15.53519 -23.43978 11.06007  0.235 30.91899 ? 48  ASP A CB   1 
ATOM   914  C  CG   A ASP A 1 48  ? -14.22177 -22.92182 10.51855  0.765 31.32296 ? 48  ASP A CG   1 
ATOM   915  C  CG   B ASP A 1 48  ? -14.25815 -23.02388 10.36273  0.235 31.66933 ? 48  ASP A CG   1 
ATOM   916  O  OD1  A ASP A 1 48  ? -14.22689 -22.14457 9.53313   0.765 27.34719 ? 48  ASP A OD1  1 
ATOM   917  O  OD1  B ASP A 1 48  ? -13.79286 -23.77620 9.48015   0.235 32.86601 ? 48  ASP A OD1  1 
ATOM   918  O  OD2  A ASP A 1 48  ? -13.16982 -23.28596 11.07891  0.765 33.97971 ? 48  ASP A OD2  1 
ATOM   919  O  OD2  B ASP A 1 48  ? -13.72890 -21.93806 10.68689  0.235 30.09012 ? 48  ASP A OD2  1 
ATOM   920  H  H    A ASP A 1 48  ? -16.04478 -23.73733 8.66741   0.765 36.86785 ? 48  ASP A H    1 
ATOM   921  H  H    B ASP A 1 48  ? -16.04671 -23.73417 8.67599   0.235 37.00248 ? 48  ASP A H    1 
ATOM   922  H  HA   A ASP A 1 48  ? -17.53884 -23.29609 10.81412  0.765 39.05384 ? 48  ASP A HA   1 
ATOM   923  H  HA   B ASP A 1 48  ? -17.56273 -23.30255 10.80368  0.235 39.12349 ? 48  ASP A HA   1 
ATOM   924  H  HB2  A ASP A 1 48  ? -15.59299 -23.21824 11.99812  0.765 36.91837 ? 48  ASP A HB2  1 
ATOM   925  H  HB2  B ASP A 1 48  ? -15.52559 -23.06341 11.95403  0.235 37.10343 ? 48  ASP A HB2  1 
ATOM   926  H  HB3  A ASP A 1 48  ? -15.49869 -24.44074 10.98717  0.765 36.91837 ? 48  ASP A HB3  1 
ATOM   927  H  HB3  B ASP A 1 48  ? -15.54947 -24.40849 11.10809  0.235 37.10343 ? 48  ASP A HB3  1 
ATOM   928  N  N    . GLY A 1 49  ? -16.95866 -20.75652 9.23668   1.000 30.57333 ? 49  GLY A N    1 
ATOM   929  C  CA   . GLY A 1 49  ? -17.06094 -19.31539 9.19298   1.000 28.97532 ? 49  GLY A CA   1 
ATOM   930  C  C    . GLY A 1 49  ? -15.74769 -18.60233 8.95184   1.000 27.37859 ? 49  GLY A C    1 
ATOM   931  O  O    . GLY A 1 49  ? -15.74413 -17.37892 8.75395   1.000 29.35978 ? 49  GLY A O    1 
ATOM   932  H  H    . GLY A 1 49  ? -16.96175 -21.12272 8.45855   1.000 36.68864 ? 49  GLY A H    1 
ATOM   933  H  HA2  . GLY A 1 49  ? -17.66997 -19.06684 8.48010   1.000 34.77102 ? 49  GLY A HA2  1 
ATOM   934  H  HA3  . GLY A 1 49  ? -17.41920 -19.00180 10.03809  1.000 34.77102 ? 49  GLY A HA3  1 
ATOM   935  N  N    . SER A 1 50  ? -14.63997 -19.31891 9.01214   1.000 24.34187 ? 50  SER A N    1 
ATOM   936  C  CA   . SER A 1 50  ? -13.36272 -18.73328 8.66534   1.000 21.86927 ? 50  SER A CA   1 
ATOM   937  C  C    . SER A 1 50  ? -13.26562 -18.62476 7.14668   1.000 20.12836 ? 50  SER A C    1 
ATOM   938  O  O    . SER A 1 50  ? -14.08541 -19.15175 6.40839   1.000 21.87580 ? 50  SER A O    1 
ATOM   939  C  CB   . SER A 1 50  ? -12.22093 -19.55700 9.22737   1.000 22.51924 ? 50  SER A CB   1 
ATOM   940  O  OG   . SER A 1 50  ? -12.22470 -20.85006 8.66629   1.000 23.36399 ? 50  SER A OG   1 
ATOM   941  H  H    . SER A 1 50  ? -14.60259 -20.14439 9.25045   1.000 29.21089 ? 50  SER A H    1 
ATOM   942  H  HA   . SER A 1 50  ? -13.28546 -17.84643 9.05059   1.000 26.24376 ? 50  SER A HA   1 
ATOM   943  H  HB2  . SER A 1 50  ? -11.38067 -19.12131 9.01514   1.000 27.02373 ? 50  SER A HB2  1 
ATOM   944  H  HB3  . SER A 1 50  ? -12.32414 -19.62801 10.18924  1.000 27.02373 ? 50  SER A HB3  1 
ATOM   945  H  HG   . SER A 1 50  ? -13.01470 -21.11687 8.56474   1.000 28.03743 ? 50  SER A HG   1 
ATOM   946  N  N    . THR A 1 51  ? -12.26533 -17.88763 6.69601   1.000 18.73349 ? 51  THR A N    1 
ATOM   947  C  CA   . THR A 1 51  ? -12.01426 -17.65853 5.27511   1.000 16.14765 ? 51  THR A CA   1 
ATOM   948  C  C    . THR A 1 51  ? -10.53369 -17.89752 4.99098   1.000 16.23345 ? 51  THR A C    1 
ATOM   949  O  O    . THR A 1 51  ? -9.67161  -17.60897 5.81523   1.000 17.29676 ? 51  THR A O    1 
ATOM   950  C  CB   . THR A 1 51  ? -12.40476 -16.21119 4.93241   1.000 18.29133 ? 51  THR A CB   1 
ATOM   951  O  OG1  . THR A 1 51  ? -13.79041 -16.01312 5.24181   1.000 20.16104 ? 51  THR A OG1  1 
ATOM   952  C  CG2  . THR A 1 51  ? -12.20857 -15.90915 3.47514   1.000 21.22240 ? 51  THR A CG2  1 
ATOM   953  H  H    . THR A 1 51  ? -11.69649 -17.49430 7.20721   1.000 22.48083 ? 51  THR A H    1 
ATOM   954  H  HA   . THR A 1 51  ? -12.51739 -18.26825 4.71298   1.000 19.37782 ? 51  THR A HA   1 
ATOM   955  H  HB   . THR A 1 51  ? -11.84152 -15.61139 5.44612   1.000 21.95023 ? 51  THR A HB   1 
ATOM   956  H  HG1  . THR A 1 51  ? -13.93392 -16.19796 6.04855   1.000 24.19389 ? 51  THR A HG1  1 
ATOM   957  H  HG21 . THR A 1 51  ? -12.47784 -14.99661 3.28628   1.000 25.46752 ? 51  THR A HG21 1 
ATOM   958  H  HG22 . THR A 1 51  ? -11.27461 -16.01754 3.23667   1.000 25.46752 ? 51  THR A HG22 1 
ATOM   959  H  HG23 . THR A 1 51  ? -12.74319 -16.51305 2.93626   1.000 25.46752 ? 51  THR A HG23 1 
ATOM   960  N  N    A ASP A 1 52  ? -10.24105 -18.39430 3.79189   0.421 17.11762 ? 52  ASP A N    1 
ATOM   961  N  N    B ASP A 1 52  ? -10.25129 -18.43229 3.80645   0.579 17.04858 ? 52  ASP A N    1 
ATOM   962  C  CA   A ASP A 1 52  ? -8.88031  -18.62105 3.32074   0.421 17.29784 ? 52  ASP A CA   1 
ATOM   963  C  CA   B ASP A 1 52  ? -8.90264  -18.60983 3.29273   0.579 17.24777 ? 52  ASP A CA   1 
ATOM   964  C  C    A ASP A 1 52  ? -8.52069  -17.57821 2.26758   0.421 16.00800 ? 52  ASP A C    1 
ATOM   965  C  C    B ASP A 1 52  ? -8.55749  -17.48281 2.32221   0.579 15.86420 ? 52  ASP A C    1 
ATOM   966  O  O    A ASP A 1 52  ? -9.30630  -17.33426 1.34138   0.421 17.77057 ? 52  ASP A O    1 
ATOM   967  O  O    B ASP A 1 52  ? -9.40164  -17.05233 1.52814   0.579 17.76221 ? 52  ASP A O    1 
ATOM   968  C  CB   A ASP A 1 52  ? -8.76606  -20.02716 2.71944   0.421 18.02227 ? 52  ASP A CB   1 
ATOM   969  C  CB   B ASP A 1 52  ? -8.80514  -19.95772 2.56600   0.579 18.11160 ? 52  ASP A CB   1 
ATOM   970  C  CG   A ASP A 1 52  ? -9.57244  -21.04857 3.48704   0.421 18.05106 ? 52  ASP A CG   1 
ATOM   971  C  CG   B ASP A 1 52  ? -8.81616  -21.13045 3.51491   0.579 19.08199 ? 52  ASP A CG   1 
ATOM   972  O  OD1  A ASP A 1 52  ? -9.33381  -21.21242 4.70183   0.421 19.71801 ? 52  ASP A OD1  1 
ATOM   973  O  OD1  B ASP A 1 52  ? -8.65702  -20.92827 4.73836   0.579 18.33867 ? 52  ASP A OD1  1 
ATOM   974  O  OD2  A ASP A 1 52  ? -10.46895 -21.67218 2.87797   0.421 27.75348 ? 52  ASP A OD2  1 
ATOM   975  O  OD2  B ASP A 1 52  ? -8.95228  -22.26477 3.01404   0.579 24.55655 ? 52  ASP A OD2  1 
ATOM   976  H  H    A ASP A 1 52  ? -10.83733 -18.61546 3.21297   0.421 20.54179 ? 52  ASP A H    1 
ATOM   977  H  H    B ASP A 1 52  ? -10.85332 -18.71168 3.25954   0.579 20.45893 ? 52  ASP A H    1 
ATOM   978  H  HA   A ASP A 1 52  ? -8.25602  -18.53245 4.05784   0.421 20.75805 ? 52  ASP A HA   1 
ATOM   979  H  HA   B ASP A 1 52  ? -8.26264  -18.58700 4.02128   0.579 20.69796 ? 52  ASP A HA   1 
ATOM   980  H  HB2  A ASP A 1 52  ? -9.09277  -20.00950 1.80629   0.421 21.62737 ? 52  ASP A HB2  1 
ATOM   981  H  HB2  B ASP A 1 52  ? -9.56180  -20.04945 1.96604   0.579 21.73457 ? 52  ASP A HB2  1 
ATOM   982  H  HB3  A ASP A 1 52  ? -7.83655  -20.30412 2.73394   0.421 21.62737 ? 52  ASP A HB3  1 
ATOM   983  H  HB3  B ASP A 1 52  ? -7.97680  -19.98660 2.06210   0.579 21.73457 ? 52  ASP A HB3  1 
ATOM   984  N  N    . TYR A 1 53  ? -7.31253  -17.01383 2.38347   1.000 16.38399 ? 53  TYR A N    1 
ATOM   985  C  CA   . TYR A 1 53  ? -6.89643  -15.83557 1.63213   1.000 16.83425 ? 53  TYR A CA   1 
ATOM   986  C  C    . TYR A 1 53  ? -5.59856  -16.02154 0.85389   1.000 17.43933 ? 53  TYR A C    1 
ATOM   987  O  O    . TYR A 1 53  ? -4.57335  -16.45244 1.40596   1.000 17.96698 ? 53  TYR A O    1 
ATOM   988  C  CB   . TYR A 1 53  ? -6.66807  -14.66739 2.60198   1.000 17.37788 ? 53  TYR A CB   1 
ATOM   989  C  CG   . TYR A 1 53  ? -7.90512  -14.18274 3.31392   1.000 18.46795 ? 53  TYR A CG   1 
ATOM   990  C  CD1  . TYR A 1 53  ? -8.32688  -14.76893 4.49830   1.000 18.95203 ? 53  TYR A CD1  1 
ATOM   991  C  CD2  . TYR A 1 53  ? -8.67819  -13.14404 2.78266   1.000 18.92196 ? 53  TYR A CD2  1 
ATOM   992  C  CE1  . TYR A 1 53  ? -9.47778  -14.34674 5.12814   1.000 16.96870 ? 53  TYR A CE1  1 
ATOM   993  C  CE2  . TYR A 1 53  ? -9.82812  -12.71844 3.42243   1.000 19.17571 ? 53  TYR A CE2  1 
ATOM   994  C  CZ   . TYR A 1 53  ? -10.19927 -13.31169 4.58138   1.000 17.59110 ? 53  TYR A CZ   1 
ATOM   995  O  OH   . TYR A 1 53  ? -11.35157 -12.90363 5.23213   1.000 18.98885 ? 53  TYR A OH   1 
ATOM   996  H  H    . TYR A 1 53  ? -6.68480  -17.36268 2.85660   1.000 19.66143 ? 53  TYR A H    1 
ATOM   997  H  HA   . TYR A 1 53  ? -7.59347  -15.66793 0.97873   1.000 20.20174 ? 53  TYR A HA   1 
ATOM   998  H  HB2  . TYR A 1 53  ? -6.03393  -14.94976 3.27950   1.000 20.85409 ? 53  TYR A HB2  1 
ATOM   999  H  HB3  . TYR A 1 53  ? -6.30768  -13.91850 2.10180   1.000 20.85409 ? 53  TYR A HB3  1 
ATOM   1000 H  HD1  . TYR A 1 53  ? -7.82565  -15.45694 4.87287   1.000 22.74308 ? 53  TYR A HD1  1 
ATOM   1001 H  HD2  . TYR A 1 53  ? -8.41545  -12.73505 1.98981   1.000 22.70699 ? 53  TYR A HD2  1 
ATOM   1002 H  HE1  . TYR A 1 53  ? -9.76274  -14.75661 5.91281   1.000 20.36308 ? 53  TYR A HE1  1 
ATOM   1003 H  HE2  . TYR A 1 53  ? -10.34086 -12.03218 3.06044   1.000 23.01150 ? 53  TYR A HE2  1 
ATOM   1004 H  HH   . TYR A 1 53  ? -11.61388 -13.50530 5.75633   1.000 22.78726 ? 53  TYR A HH   1 
ATOM   1005 N  N    . GLY A 1 54  ? -5.64985  -15.63493 -0.42068  1.000 16.78255 ? 54  GLY A N    1 
ATOM   1006 C  CA   . GLY A 1 54  ? -4.45015  -15.40178 -1.21270  1.000 18.53820 ? 54  GLY A CA   1 
ATOM   1007 C  C    . GLY A 1 54  ? -3.93344  -16.63487 -1.91498  1.000 16.91002 ? 54  GLY A C    1 
ATOM   1008 O  O    . GLY A 1 54  ? -4.56777  -17.68078 -1.99476  1.000 17.84702 ? 54  GLY A O    1 
ATOM   1009 H  H    . GLY A 1 54  ? -6.38012  -15.49933 -0.85418  1.000 20.13971 ? 54  GLY A H    1 
ATOM   1010 H  HA2  . GLY A 1 54  ? -4.64276  -14.73160 -1.88699  1.000 22.24648 ? 54  GLY A HA2  1 
ATOM   1011 H  HA3  . GLY A 1 54  ? -3.74753  -15.07174 -0.63107  1.000 22.24648 ? 54  GLY A HA3  1 
ATOM   1012 N  N    . ILE A 1 55  ? -2.71166  -16.47037 -2.43736  1.000 18.42871 ? 55  ILE A N    1 
ATOM   1013 C  CA   . ILE A 1 55  ? -2.07780  -17.46428 -3.28965  1.000 19.37011 ? 55  ILE A CA   1 
ATOM   1014 C  C    . ILE A 1 55  ? -1.91608  -18.80268 -2.58958  1.000 17.66259 ? 55  ILE A C    1 
ATOM   1015 O  O    . ILE A 1 55  ? -1.98022  -19.84804 -3.24036  1.000 19.49396 ? 55  ILE A O    1 
ATOM   1016 C  CB   . ILE A 1 55  ? -0.76040  -16.83012 -3.77656  1.000 25.15810 ? 55  ILE A CB   1 
ATOM   1017 C  CG1  . ILE A 1 55  ? -0.20476  -17.56062 -4.98161  1.000 37.53678 ? 55  ILE A CG1  1 
ATOM   1018 C  CG2  . ILE A 1 55  ? 0.28149   -16.78623 -2.68256  1.000 26.80352 ? 55  ILE A CG2  1 
ATOM   1019 C  CD1  . ILE A 1 55  ? -0.56440  -16.89539 -6.23963  1.000 42.27274 ? 55  ILE A CD1  1 
ATOM   1020 H  H    . ILE A 1 55  ? -2.22284  -15.77488 -2.30721  1.000 22.11509 ? 55  ILE A H    1 
ATOM   1021 H  HA   . ILE A 1 55  ? -2.63100  -17.68165 -4.05622  1.000 23.24478 ? 55  ILE A HA   1 
ATOM   1022 H  HB   . ILE A 1 55  ? -0.97557  -15.92001 -4.03406  1.000 30.19036 ? 55  ILE A HB   1 
ATOM   1023 H  HG12 . ILE A 1 55  ? 0.76279   -17.58940 -4.91895  1.000 45.04478 ? 55  ILE A HG12 1 
ATOM   1024 H  HG13 . ILE A 1 55  ? -0.56289  -18.46187 -5.00132  1.000 45.04478 ? 55  ILE A HG13 1 
ATOM   1025 H  HG21 . ILE A 1 55  ? 1.09409   -16.39168 -3.03599  1.000 32.16486 ? 55  ILE A HG21 1 
ATOM   1026 H  HG22 . ILE A 1 55  ? -0.05448  -16.24936 -1.94785  1.000 32.16486 ? 55  ILE A HG22 1 
ATOM   1027 H  HG23 . ILE A 1 55  ? 0.45795   -17.69013 -2.37806  1.000 32.16486 ? 55  ILE A HG23 1 
ATOM   1028 H  HD11 . ILE A 1 55  ? -0.16832  -17.38262 -6.97897  1.000 50.72792 ? 55  ILE A HD11 1 
ATOM   1029 H  HD12 . ILE A 1 55  ? -1.53034  -16.88795 -6.32802  1.000 50.72792 ? 55  ILE A HD12 1 
ATOM   1030 H  HD13 . ILE A 1 55  ? -0.22668  -15.98622 -6.22388  1.000 50.72792 ? 55  ILE A HD13 1 
ATOM   1031 N  N    . LEU A 1 56  ? -1.73047  -18.81190 -1.27031  1.000 18.48998 ? 56  LEU A N    1 
ATOM   1032 C  CA   . LEU A 1 56  ? -1.58952  -20.03992 -0.50038  1.000 17.89043 ? 56  LEU A CA   1 
ATOM   1033 C  C    . LEU A 1 56  ? -2.76750  -20.26909 0.45449   1.000 19.92330 ? 56  LEU A C    1 
ATOM   1034 O  O    . LEU A 1 56  ? -2.71619  -21.14678 1.32998   1.000 20.32189 ? 56  LEU A O    1 
ATOM   1035 C  CB   . LEU A 1 56  ? -0.25435  -20.06422 0.23411   1.000 22.09105 ? 56  LEU A CB   1 
ATOM   1036 C  CG   . LEU A 1 56  ? 0.96263   -20.33156 -0.67220  1.000 22.68076 ? 56  LEU A CG   1 
ATOM   1037 C  CD1  . LEU A 1 56  ? 2.26473   -19.97446 0.05941   1.000 28.03936 ? 56  LEU A CD1  1 
ATOM   1038 C  CD2  . LEU A 1 56  ? 0.94249   -21.79096 -1.11243  1.000 25.88996 ? 56  LEU A CD2  1 
ATOM   1039 H  H    . LEU A 1 56  ? -1.68195  -18.10026 -0.78987  1.000 22.18861 ? 56  LEU A H    1 
ATOM   1040 H  HA   . LEU A 1 56  ? -1.58158  -20.79006 -1.11530  1.000 21.46916 ? 56  LEU A HA   1 
ATOM   1041 H  HB2  . LEU A 1 56  ? -0.12049  -19.20339 0.66066   1.000 26.50990 ? 56  LEU A HB2  1 
ATOM   1042 H  HB3  . LEU A 1 56  ? -0.28263  -20.76546 0.90372   1.000 26.50990 ? 56  LEU A HB3  1 
ATOM   1043 H  HG   . LEU A 1 56  ? 0.92532   -19.77423 -1.46523  1.000 27.21755 ? 56  LEU A HG   1 
ATOM   1044 H  HD11 . LEU A 1 56  ? 3.01409   -20.12530 -0.53777  1.000 33.64788 ? 56  LEU A HD11 1 
ATOM   1045 H  HD12 . LEU A 1 56  ? 2.23369   -19.04120 0.32201   1.000 33.64788 ? 56  LEU A HD12 1 
ATOM   1046 H  HD13 . LEU A 1 56  ? 2.34974   -20.53658 0.84535   1.000 33.64788 ? 56  LEU A HD13 1 
ATOM   1047 H  HD21 . LEU A 1 56  ? 1.78428   -22.00171 -1.54588  1.000 31.06859 ? 56  LEU A HD21 1 
ATOM   1048 H  HD22 . LEU A 1 56  ? 0.82199   -22.35454 -0.33220  1.000 31.06859 ? 56  LEU A HD22 1 
ATOM   1049 H  HD23 . LEU A 1 56  ? 0.20869   -21.92358 -1.73279  1.000 31.06859 ? 56  LEU A HD23 1 
ATOM   1050 N  N    . GLN A 1 57  ? -3.88057  -19.55668 0.25982   1.000 17.29253 ? 57  GLN A N    1 
ATOM   1051 C  CA   . GLN A 1 57  ? -5.13155  -19.86285 0.96483   1.000 16.61016 ? 57  GLN A CA   1 
ATOM   1052 C  C    . GLN A 1 57  ? -4.94415  -20.00162 2.47910   1.000 18.93871 ? 57  GLN A C    1 
ATOM   1053 O  O    . GLN A 1 57  ? -5.39523  -20.96694 3.09618   1.000 20.61891 ? 57  GLN A O    1 
ATOM   1054 C  CB   . GLN A 1 57  ? -5.82915  -21.06058 0.34049   1.000 18.02454 ? 57  GLN A CB   1 
ATOM   1055 C  CG   . GLN A 1 57  ? -6.37842  -20.74365 -1.05160  1.000 18.09918 ? 57  GLN A CG   1 
ATOM   1056 C  CD   . GLN A 1 57  ? -7.55891  -19.81809 -1.00458  1.000 17.11567 ? 57  GLN A CD   1 
ATOM   1057 O  OE1  . GLN A 1 57  ? -8.66477  -20.23767 -0.74473  1.000 20.05963 ? 57  GLN A OE1  1 
ATOM   1058 N  NE2  . GLN A 1 57  ? -7.31271  -18.53453 -1.20364  1.000 19.51550 ? 57  GLN A NE2  1 
ATOM   1059 H  H    . GLN A 1 57  ? -3.93775  -18.88790 -0.27783  1.000 20.75168 ? 57  GLN A H    1 
ATOM   1060 H  HA   . GLN A 1 57  ? -5.72205  -19.10049 0.85983   1.000 19.93283 ? 57  GLN A HA   1 
ATOM   1061 H  HB2  . GLN A 1 57  ? -5.19572  -21.79053 0.25778   1.000 21.63009 ? 57  GLN A HB2  1 
ATOM   1062 H  HB3  . GLN A 1 57  ? -6.57085  -21.32739 0.90580   1.000 21.63009 ? 57  GLN A HB3  1 
ATOM   1063 H  HG2  . GLN A 1 57  ? -5.68317  -20.31871 -1.57787  1.000 21.71966 ? 57  GLN A HG2  1 
ATOM   1064 H  HG3  . GLN A 1 57  ? -6.65925  -21.56874 -1.47734  1.000 21.71966 ? 57  GLN A HG3  1 
ATOM   1065 H  HE21 . GLN A 1 57  ? -6.50812  -18.26875 -1.35060  1.000 23.41924 ? 57  GLN A HE21 1 
ATOM   1066 H  HE22 . GLN A 1 57  ? -7.95715  -17.96532 -1.18616  1.000 23.41924 ? 57  GLN A HE22 1 
ATOM   1067 N  N    . ILE A 1 58  ? -4.34745  -18.98388 3.07432   1.000 18.50713 ? 58  ILE A N    1 
ATOM   1068 C  CA   . ILE A 1 58  ? -4.06490  -18.95726 4.51301   1.000 19.04235 ? 58  ILE A CA   1 
ATOM   1069 C  C    . ILE A 1 58  ? -5.34711  -18.62160 5.27621   0.777 15.59913 ? 58  ILE A C    1 
ATOM   1070 O  O    . ILE A 1 58  ? -6.05715  -17.66618 4.93101   1.000 18.78535 ? 58  ILE A O    1 
ATOM   1071 C  CB   . ILE A 1 58  ? -2.91938  -17.98270 4.77561   0.975 20.62605 ? 58  ILE A CB   1 
ATOM   1072 C  CG1  . ILE A 1 58  ? -1.61981  -18.58825 4.18983   1.000 22.38326 ? 58  ILE A CG1  1 
ATOM   1073 C  CG2  . ILE A 1 58  ? -2.79006  -17.67438 6.27271   0.816 19.56735 ? 58  ILE A CG2  1 
ATOM   1074 C  CD1  . ILE A 1 58  ? -0.48202  -17.66353 4.14203   0.754 21.29097 ? 58  ILE A CD1  1 
ATOM   1075 H  H    . ILE A 1 58  ? -4.08656  -18.27479 2.66355   1.000 22.20920 ? 58  ILE A H    1 
ATOM   1076 H  HA   . ILE A 1 58  ? -3.79139  -19.83167 4.83161   0.834 22.85147 ? 58  ILE A HA   1 
ATOM   1077 H  HB   . ILE A 1 58  ? -3.09868  -17.13590 4.33780   1.000 24.75190 ? 58  ILE A HB   1 
ATOM   1078 H  HG12 . ILE A 1 58  ? -1.35837  -19.34542 4.73687   1.000 26.86056 ? 58  ILE A HG12 1 
ATOM   1079 H  HG13 . ILE A 1 58  ? -1.79743  -18.88039 3.28209   1.000 26.86056 ? 58  ILE A HG13 1 
ATOM   1080 H  HG21 . ILE A 1 58  ? -1.98865  -17.14774 6.41860   1.000 23.48146 ? 58  ILE A HG21 1 
ATOM   1081 H  HG22 . ILE A 1 58  ? -3.57056  -17.17578 6.56102   0.748 23.48146 ? 58  ILE A HG22 1 
ATOM   1082 H  HG23 . ILE A 1 58  ? -2.73111  -18.50920 6.76312   0.814 23.48146 ? 58  ILE A HG23 1 
ATOM   1083 H  HD11 . ILE A 1 58  ? 0.25385   -18.09200 3.67749   0.663 25.54980 ? 58  ILE A HD11 1 
ATOM   1084 H  HD12 . ILE A 1 58  ? -0.74824  -16.85943 3.66934   0.538 25.54980 ? 58  ILE A HD12 1 
ATOM   1085 H  HD13 . ILE A 1 58  ? -0.21686  -17.44196 5.04840   0.359 25.54980 ? 58  ILE A HD13 1 
ATOM   1086 N  N    A ASN A 1 59  ? -5.66868  -19.42533 6.29130   0.250 18.81676 ? 59  ASN A N    1 
ATOM   1087 N  N    B ASN A 1 59  ? -5.61037  -19.39824 6.34076   0.352 18.86294 ? 59  ASN A N    1 
ATOM   1088 N  N    C ASN A 1 59  ? -5.62220  -19.38072 6.35046   0.398 18.85740 ? 59  ASN A N    1 
ATOM   1089 C  CA   A ASN A 1 59  ? -6.98245  -19.36035 6.91948   0.250 18.83929 ? 59  ASN A CA   1 
ATOM   1090 C  CA   B ASN A 1 59  ? -6.87987  -19.42274 7.06468   0.352 18.68061 ? 59  ASN A CA   1 
ATOM   1091 C  CA   C ASN A 1 59  ? -6.93375  -19.42151 7.00157   0.398 18.74875 ? 59  ASN A CA   1 
ATOM   1092 C  C    A ASN A 1 59  ? -6.99607  -18.41079 8.10963   0.250 20.09738 ? 59  ASN A C    1 
ATOM   1093 C  C    B ASN A 1 59  ? -6.93690  -18.32936 8.12517   0.352 20.16807 ? 59  ASN A C    1 
ATOM   1094 C  C    C ASN A 1 59  ? -7.03458  -18.48209 8.19889   0.398 19.98757 ? 59  ASN A C    1 
ATOM   1095 O  O    A ASN A 1 59  ? -6.04515  -18.34411 8.89433   0.250 22.30055 ? 59  ASN A O    1 
ATOM   1096 O  O    B ASN A 1 59  ? -5.94392  -18.04630 8.80529   0.352 19.99224 ? 59  ASN A O    1 
ATOM   1097 O  O    C ASN A 1 59  ? -6.20825  -18.54221 9.11212   0.398 22.16847 ? 59  ASN A O    1 
ATOM   1098 C  CB   A ASN A 1 59  ? -7.43014  -20.74969 7.36840   0.250 22.29017 ? 59  ASN A CB   1 
ATOM   1099 C  CB   B ASN A 1 59  ? -7.02236  -20.79938 7.73696   0.352 22.34542 ? 59  ASN A CB   1 
ATOM   1100 C  CB   C ASN A 1 59  ? -7.21385  -20.84789 7.48538   0.398 23.25145 ? 59  ASN A CB   1 
ATOM   1101 C  CG   A ASN A 1 59  ? -6.80577  -21.15306 8.67816   0.250 20.00103 ? 59  ASN A CG   1 
ATOM   1102 C  CG   B ASN A 1 59  ? -8.46112  -21.15195 8.08447   0.352 22.28010 ? 59  ASN A CG   1 
ATOM   1103 C  CG   C ASN A 1 59  ? -8.52329  -20.96198 8.22447   0.398 23.10902 ? 59  ASN A CG   1 
ATOM   1104 O  OD1  A ASN A 1 59  ? -7.13745  -20.60551 9.73192   0.250 24.04417 ? 59  ASN A OD1  1 
ATOM   1105 O  OD1  B ASN A 1 59  ? -9.29025  -20.28602 8.32929   0.352 21.53418 ? 59  ASN A OD1  1 
ATOM   1106 O  OD1  C ASN A 1 59  ? -8.58767  -20.79755 9.45222   0.398 25.02703 ? 59  ASN A OD1  1 
ATOM   1107 N  ND2  A ASN A 1 59  ? -5.88162  -22.10255 8.62779   0.250 25.69254 ? 59  ASN A ND2  1 
ATOM   1108 N  ND2  B ASN A 1 59  ? -8.74994  -22.44238 8.13857   0.352 22.02362 ? 59  ASN A ND2  1 
ATOM   1109 N  ND2  C ASN A 1 59  ? -9.57863  -21.25530 7.48892   0.398 24.33336 ? 59  ASN A ND2  1 
ATOM   1110 H  H    A ASN A 1 59  ? -5.14216  -20.01431 6.63113   0.154 22.58076 ? 59  ASN A H    1 
ATOM   1111 H  H    B ASN A 1 59  ? -5.03692  -19.94509 6.67500   0.000 22.63616 ? 59  ASN A H    1 
ATOM   1112 H  H    C ASN A 1 59  ? -5.04484  -19.89432 6.72791   0.000 22.62951 ? 59  ASN A H    1 
ATOM   1113 H  HA   A ASN A 1 59  ? -7.61374  -19.01775 6.26757   0.250 22.60779 ? 59  ASN A HA   1 
ATOM   1114 H  HA   B ASN A 1 59  ? -7.61561  -19.26382 6.45286   0.352 22.41737 ? 59  ASN A HA   1 
ATOM   1115 H  HA   C ASN A 1 59  ? -7.59149  -19.12297 6.35415   0.398 22.49914 ? 59  ASN A HA   1 
ATOM   1116 H  HB2  A ASN A 1 59  ? -8.39380  -20.75322 7.47909   0.250 26.74884 ? 59  ASN A HB2  1 
ATOM   1117 H  HB2  B ASN A 1 59  ? -6.68636  -21.48018 7.13321   0.352 26.81515 ? 59  ASN A HB2  1 
ATOM   1118 H  HB2  C ASN A 1 59  ? -7.24854  -21.44131 6.71886   0.398 27.90238 ? 59  ASN A HB2  1 
ATOM   1119 H  HB3  A ASN A 1 59  ? -7.17094  -21.39999 6.69696   0.250 26.74884 ? 59  ASN A HB3  1 
ATOM   1120 H  HB3  B ASN A 1 59  ? -6.50804  -20.80218 8.55937   0.352 26.81515 ? 59  ASN A HB3  1 
ATOM   1121 H  HB3  C ASN A 1 59  ? -6.50426  -21.12358 8.08652   0.398 27.90238 ? 59  ASN A HB3  1 
ATOM   1122 H  HD21 A ASN A 1 59  ? -5.49651  -22.36652 9.35002   0.250 30.83169 ? 59  ASN A HD21 1 
ATOM   1123 H  HD21 B ASN A 1 59  ? -9.54872  -22.69656 8.33076   0.352 26.42899 ? 59  ASN A HD21 1 
ATOM   1124 H  HD21 C ASN A 1 59  ? -10.35167 -21.33288 7.85768   0.398 29.20067 ? 59  ASN A HD21 1 
ATOM   1125 H  HD22 A ASN A 1 59  ? -5.66733  -22.45442 7.87289   0.250 30.83169 ? 59  ASN A HD22 1 
ATOM   1126 H  HD22 B ASN A 1 59  ? -8.13882  -23.02675 7.98154   0.352 26.42899 ? 59  ASN A HD22 1 
ATOM   1127 H  HD22 C ASN A 1 59  ? -9.49346  -21.36892 6.64073   0.398 29.20067 ? 59  ASN A HD22 1 
ATOM   1128 N  N    . SER A 1 60  ? -8.09433  -17.66970 8.22156   1.000 18.09995 ? 60  SER A N    1 
ATOM   1129 C  CA   . SER A 1 60  ? -8.31000  -16.68894 9.28082   1.000 17.79377 ? 60  SER A CA   1 
ATOM   1130 C  C    . SER A 1 60  ? -8.59827  -17.28511 10.65055  1.000 19.74271 ? 60  SER A C    1 
ATOM   1131 O  O    . SER A 1 60  ? -8.60165  -16.51765 11.62276  1.000 23.78719 ? 60  SER A O    1 
ATOM   1132 C  CB   . SER A 1 60  ? -9.49498  -15.78471 8.91509   1.000 19.76172 ? 60  SER A CB   1 
ATOM   1133 O  OG   . SER A 1 60  ? -10.69350 -16.49711 8.82422   1.000 20.18474 ? 60  SER A OG   1 
ATOM   1134 H  H    . SER A 1 60  ? -8.71120  -17.67034 7.62232   0.827 21.72058 ? 60  SER A H    1 
ATOM   1135 H  HA   . SER A 1 60  ? -7.49559  -16.16658 9.34994   1.000 21.35316 ? 60  SER A HA   1 
ATOM   1136 H  HB2  . SER A 1 60  ? -9.58937  -15.10445 9.60009   1.000 23.71470 ? 60  SER A HB2  1 
ATOM   1137 H  HB3  . SER A 1 60  ? -9.31512  -15.36906 8.05731   1.000 23.71470 ? 60  SER A HB3  1 
ATOM   1138 H  HG   . SER A 1 60  ? -10.87323 -16.85255 9.56379   1.000 24.22233 ? 60  SER A HG   1 
ATOM   1139 N  N    A ARG A 1 61  ? -8.80955  -18.58684 10.77850  0.497 20.50267 ? 61  ARG A N    1 
ATOM   1140 N  N    B ARG A 1 61  ? -8.86760  -18.59063 10.70578  0.503 20.48823 ? 61  ARG A N    1 
ATOM   1141 C  CA   A ARG A 1 61  ? -9.00370  -19.16115 12.11640  0.497 24.09790 ? 61  ARG A CA   1 
ATOM   1142 C  CA   B ARG A 1 61  ? -9.13385  -19.27562 11.96935  0.503 25.34036 ? 61  ARG A CA   1 
ATOM   1143 C  C    A ARG A 1 61  ? -7.73407  -19.02896 12.94924  0.497 25.95194 ? 61  ARG A C    1 
ATOM   1144 C  C    B ARG A 1 61  ? -7.90734  -19.27679 12.85931  0.503 23.54931 ? 61  ARG A C    1 
ATOM   1145 O  O    A ARG A 1 61  ? -7.77901  -18.68208 14.14290  0.497 22.92427 ? 61  ARG A O    1 
ATOM   1146 O  O    B ARG A 1 61  ? -8.04702  -19.35582 14.08413  0.503 24.32785 ? 61  ARG A O    1 
ATOM   1147 C  CB   A ARG A 1 61  ? -9.41261  -20.63002 11.96103  0.497 28.00877 ? 61  ARG A CB   1 
ATOM   1148 C  CB   B ARG A 1 61  ? -9.58121  -20.71776 11.69006  0.503 29.01564 ? 61  ARG A CB   1 
ATOM   1149 C  CG   A ARG A 1 61  ? -9.42268  -21.49601 13.22306  0.497 40.27208 ? 61  ARG A CG   1 
ATOM   1150 C  CG   B ARG A 1 61  ? -9.72528  -21.62672 12.91739  0.503 40.47172 ? 61  ARG A CG   1 
ATOM   1151 C  CD   A ARG A 1 61  ? -10.80914 -21.65897 13.81184  0.497 40.10010 ? 61  ARG A CD   1 
ATOM   1152 C  CD   B ARG A 1 61  ? -10.78889 -21.12977 13.86932  0.503 37.11504 ? 61  ARG A CD   1 
ATOM   1153 N  NE   A ARG A 1 61  ? -10.76147 -22.48968 15.01102  0.497 45.48754 ? 61  ARG A NE   1 
ATOM   1154 N  NE   B ARG A 1 61  ? -12.10945 -21.09701 13.25179  0.503 33.03618 ? 61  ARG A NE   1 
ATOM   1155 C  CZ   A ARG A 1 61  ? -10.24890 -22.10290 16.17280  0.497 52.19323 ? 61  ARG A CZ   1 
ATOM   1156 C  CZ   B ARG A 1 61  ? -13.12592 -20.37611 13.70551  0.503 38.13017 ? 61  ARG A CZ   1 
ATOM   1157 N  NH1  A ARG A 1 61  ? -9.78192  -20.87800 16.35096  0.497 49.00184 ? 61  ARG A NH1  1 
ATOM   1158 N  NH1  B ARG A 1 61  ? -13.03099 -19.68020 14.82977  0.503 36.57656 ? 61  ARG A NH1  1 
ATOM   1159 N  NH2  A ARG A 1 61  ? -10.20274 -22.96823 17.18177  0.497 55.37266 ? 61  ARG A NH2  1 
ATOM   1160 N  NH2  B ARG A 1 61  ? -14.26674 -20.35453 13.01583  0.503 28.15033 ? 61  ARG A NH2  1 
ATOM   1161 H  H    A ARG A 1 61  ? -8.84559  -19.15055 10.13001  0.497 24.60385 ? 61  ARG A H    1 
ATOM   1162 H  H    B ARG A 1 61  ? -8.90260  -19.10769 10.01946  0.503 24.58651 ? 61  ARG A H    1 
ATOM   1163 H  HA   A ARG A 1 61  ? -9.71102  -18.69210 12.58606  0.497 28.91812 ? 61  ARG A HA   1 
ATOM   1164 H  HA   B ARG A 1 61  ? -9.85043  -18.81816 12.43641  0.503 30.40907 ? 61  ARG A HA   1 
ATOM   1165 H  HB2  A ARG A 1 61  ? -10.31223 -20.65170 11.59894  0.497 33.61116 ? 61  ARG A HB2  1 
ATOM   1166 H  HB2  B ARG A 1 61  ? -10.44657 -20.68734 11.25288  0.503 34.81941 ? 61  ARG A HB2  1 
ATOM   1167 H  HB3  A ARG A 1 61  ? -8.79489  -21.04671 11.33999  0.497 33.61116 ? 61  ARG A HB3  1 
ATOM   1168 H  HB3  B ARG A 1 61  ? -8.92753  -21.12966 11.10361  0.503 34.81941 ? 61  ARG A HB3  1 
ATOM   1169 H  HG2  A ARG A 1 61  ? -9.08484  -22.37848 13.00393  0.497 48.32714 ? 61  ARG A HG2  1 
ATOM   1170 H  HG2  B ARG A 1 61  ? -9.97205  -22.51869 12.62688  0.503 48.56671 ? 61  ARG A HG2  1 
ATOM   1171 H  HG3  A ARG A 1 61  ? -8.85871  -21.08233 13.89514  0.497 48.32714 ? 61  ARG A HG3  1 
ATOM   1172 H  HG3  B ARG A 1 61  ? -8.88129  -21.65488 13.39466  0.503 48.56671 ? 61  ARG A HG3  1 
ATOM   1173 H  HD2  A ARG A 1 61  ? -11.16419 -20.78892 14.05238  0.497 48.12075 ? 61  ARG A HD2  1 
ATOM   1174 H  HD2  B ARG A 1 61  ? -10.82936 -21.72021 14.63785  0.503 44.53869 ? 61  ARG A HD2  1 
ATOM   1175 H  HD3  A ARG A 1 61  ? -11.38956 -22.08622 13.16264  0.497 48.12075 ? 61  ARG A HD3  1 
ATOM   1176 H  HD3  B ARG A 1 61  ? -10.56606 -20.22962 14.15388  0.503 44.53869 ? 61  ARG A HD3  1 
ATOM   1177 H  HE   A ARG A 1 61  ? -11.08769 -23.28387 14.96153  0.497 54.58569 ? 61  ARG A HE   1 
ATOM   1178 H  HE   B ARG A 1 61  ? -12.23725 -21.57554 12.54875  0.503 39.64406 ? 61  ARG A HE   1 
ATOM   1179 H  HH11 A ARG A 1 61  ? -9.80606  -20.31046 15.70528  0.497 58.80284 ? 61  ARG A HH11 1 
ATOM   1180 H  HH11 B ARG A 1 61  ? -13.70133 -19.21870 15.10771  0.503 43.89251 ? 61  ARG A HH11 1 
ATOM   1181 H  HH12 A ARG A 1 61  ? -9.45421  -20.64928 17.11247  0.497 58.80284 ? 61  ARG A HH12 1 
ATOM   1182 H  HH12 B ARG A 1 61  ? -12.29906 -19.69023 15.28119  0.503 43.89251 ? 61  ARG A HH12 1 
ATOM   1183 H  HH21 A ARG A 1 61  ? -10.50281 -23.76734 17.07697  0.497 66.44783 ? 61  ARG A HH21 1 
ATOM   1184 H  HH21 B ARG A 1 61  ? -14.33678 -20.80458 12.28634  0.503 33.78104 ? 61  ARG A HH21 1 
ATOM   1185 H  HH22 A ARG A 1 61  ? -9.87283  -22.72865 17.93897  0.497 66.44783 ? 61  ARG A HH22 1 
ATOM   1186 H  HH22 B ARG A 1 61  ? -14.93257 -19.89057 13.30046  0.503 33.78104 ? 61  ARG A HH22 1 
ATOM   1187 N  N    A TRP A 1 62  ? -6.58402  -19.28541 12.33336  0.497 22.29104 ? 62  TRP A N    1 
ATOM   1188 N  N    B TRP A 1 62  ? -6.70581  -19.17137 12.26744  0.503 21.27431 ? 62  TRP A N    1 
ATOM   1189 C  CA   A TRP A 1 62  ? -5.31955  -19.29838 13.05736  0.497 22.58214 ? 62  TRP A CA   1 
ATOM   1190 C  CA   B TRP A 1 62  ? -5.45610  -19.25178 13.02522  0.503 22.47284 ? 62  TRP A CA   1 
ATOM   1191 C  C    A TRP A 1 62  ? -4.36364  -18.17609 12.69671  0.497 23.59556 ? 62  TRP A C    1 
ATOM   1192 C  C    B TRP A 1 62  ? -4.40233  -18.19371 12.69397  0.503 23.47775 ? 62  TRP A C    1 
ATOM   1193 O  O    A TRP A 1 62  ? -3.61588  -17.72828 13.55706  0.497 24.32039 ? 62  TRP A O    1 
ATOM   1194 O  O    B TRP A 1 62  ? -3.62001  -17.81740 13.56304  0.503 24.31173 ? 62  TRP A O    1 
ATOM   1195 C  CB   A TRP A 1 62  ? -4.58396  -20.63491 12.84368  0.497 24.37386 ? 62  TRP A CB   1 
ATOM   1196 C  CB   B TRP A 1 62  ? -4.80573  -20.64375 12.85832  0.503 26.16764 ? 62  TRP A CB   1 
ATOM   1197 C  CG   A TRP A 1 62  ? -5.42029  -21.81702 13.14516  0.497 29.31478 ? 62  TRP A CG   1 
ATOM   1198 C  CG   B TRP A 1 62  ? -5.68133  -21.75466 13.30240  0.503 29.14508 ? 62  TRP A CG   1 
ATOM   1199 C  CD1  A TRP A 1 62  ? -6.09549  -22.59328 12.25282  0.497 30.64516 ? 62  TRP A CD1  1 
ATOM   1200 C  CD1  B TRP A 1 62  ? -6.37967  -22.61531 12.51313  0.503 33.28199 ? 62  TRP A CD1  1 
ATOM   1201 C  CD2  A TRP A 1 62  ? -5.68306  -22.36508 14.43811  0.497 37.30600 ? 62  TRP A CD2  1 
ATOM   1202 C  CD2  B TRP A 1 62  ? -5.97391  -22.11690 14.65488  0.503 35.59838 ? 62  TRP A CD2  1 
ATOM   1203 N  NE1  A TRP A 1 62  ? -6.76653  -23.59385 12.91162  0.497 40.22158 ? 62  TRP A NE1  1 
ATOM   1204 N  NE1  B TRP A 1 62  ? -7.09108  -23.49604 13.29249  0.503 37.99605 ? 62  TRP A NE1  1 
ATOM   1205 C  CE2  A TRP A 1 62  ? -6.52905  -23.47438 14.25544  0.497 36.78375 ? 62  TRP A CE2  1 
ATOM   1206 C  CE2  B TRP A 1 62  ? -6.85718  -23.21031 14.61152  0.503 37.49726 ? 62  TRP A CE2  1 
ATOM   1207 C  CE3  A TRP A 1 62  ? -5.28418  -22.02415 15.73381  0.497 40.26606 ? 62  TRP A CE3  1 
ATOM   1208 C  CE3  B TRP A 1 62  ? -5.57209  -21.62116 15.89807  0.503 39.35712 ? 62  TRP A CE3  1 
ATOM   1209 C  CZ2  A TRP A 1 62  ? -6.98079  -24.25096 15.32108  0.497 53.55867 ? 62  TRP A CZ2  1 
ATOM   1210 C  CZ2  B TRP A 1 62  ? -7.34496  -23.82278 15.76481  0.503 51.47749 ? 62  TRP A CZ2  1 
ATOM   1211 C  CZ3  A TRP A 1 62  ? -5.73017  -22.79507 16.78818  0.497 46.95357 ? 62  TRP A CZ3  1 
ATOM   1212 C  CZ3  B TRP A 1 62  ? -6.05538  -22.22813 17.04180  0.503 50.76806 ? 62  TRP A CZ3  1 
ATOM   1213 C  CH2  A TRP A 1 62  ? -6.57314  -23.89400 16.57697  0.497 50.34422 ? 62  TRP A CH2  1 
ATOM   1214 C  CH2  B TRP A 1 62  ? -6.93519  -23.31706 16.96705  0.503 49.87896 ? 62  TRP A CH2  1 
ATOM   1215 H  H    A TRP A 1 62  ? -6.51116  -19.45541 11.49349  0.497 26.74989 ? 62  TRP A H    1 
ATOM   1216 H  H    B TRP A 1 62  ? -6.59200  -19.05232 11.42336  0.503 25.52981 ? 62  TRP A H    1 
ATOM   1217 H  HA   A TRP A 1 62  ? -5.52957  -19.20927 14.00015  0.497 27.09920 ? 62  TRP A HA   1 
ATOM   1218 H  HA   B TRP A 1 62  ? -5.72086  -19.08928 13.94413  0.503 26.96805 ? 62  TRP A HA   1 
ATOM   1219 H  HB2  A TRP A 1 62  ? -4.30583  -20.69526 11.91637  0.497 29.24927 ? 62  TRP A HB2  1 
ATOM   1220 H  HB2  B TRP A 1 62  ? -4.59880  -20.78339 11.92099  0.503 31.40181 ? 62  TRP A HB2  1 
ATOM   1221 H  HB3  A TRP A 1 62  ? -3.80812  -20.66257 13.42522  0.497 29.24927 ? 62  TRP A HB3  1 
ATOM   1222 H  HB3  B TRP A 1 62  ? -3.99242  -20.67572 13.38595  0.503 31.40181 ? 62  TRP A HB3  1 
ATOM   1223 H  HD1  A TRP A 1 62  ? -6.10123  -22.46450 11.33180  0.497 36.77483 ? 62  TRP A HD1  1 
ATOM   1224 H  HD1  B TRP A 1 62  ? -6.37615  -22.60863 11.58316  0.503 39.93903 ? 62  TRP A HD1  1 
ATOM   1225 H  HE1  A TRP A 1 62  ? -7.25562  -24.19658 12.54135  0.497 48.26654 ? 62  TRP A HE1  1 
ATOM   1226 H  HE1  B TRP A 1 62  ? -7.60019  -24.12424 12.99963  0.503 45.59590 ? 62  TRP A HE1  1 
ATOM   1227 H  HE3  A TRP A 1 62  ? -4.72947  -21.29262 15.88236  0.497 48.31992 ? 62  TRP A HE3  1 
ATOM   1228 H  HE3  B TRP A 1 62  ? -4.99104  -20.89723 15.95468  0.503 47.22919 ? 62  TRP A HE3  1 
ATOM   1229 H  HZ2  A TRP A 1 62  ? -7.53753  -24.98310 15.18359  0.497 64.27105 ? 62  TRP A HZ2  1 
ATOM   1230 H  HZ2  B TRP A 1 62  ? -7.92640  -24.54710 15.71823  0.503 61.77363 ? 62  TRP A HZ2  1 
ATOM   1231 H  HZ3  A TRP A 1 62  ? -5.46649  -22.58131 17.65403  0.497 56.34492 ? 62  TRP A HZ3  1 
ATOM   1232 H  HZ3  B TRP A 1 62  ? -5.79259  -21.90890 17.87483  0.503 60.92232 ? 62  TRP A HZ3  1 
ATOM   1233 H  HH2  A TRP A 1 62  ? -6.86210  -24.39208 17.30726  0.497 60.41370 ? 62  TRP A HH2  1 
ATOM   1234 H  HH2  B TRP A 1 62  ? -7.24712  -23.70414 17.75303  0.503 59.85539 ? 62  TRP A HH2  1 
ATOM   1235 N  N    . TRP A 1 63  ? -4.32717  -17.70981 11.44355  1.000 18.38326 ? 63  TRP A N    1 
ATOM   1236 C  CA   . TRP A 1 63  ? -3.13809  -17.05756 10.95336  1.000 19.65756 ? 63  TRP A CA   1 
ATOM   1237 C  C    . TRP A 1 63  ? -3.23370  -15.57525 10.67110  1.000 18.68910 ? 63  TRP A C    1 
ATOM   1238 O  O    . TRP A 1 63  ? -2.19978  -14.90939 10.66319  1.000 20.79550 ? 63  TRP A O    1 
ATOM   1239 C  CB   . TRP A 1 63  ? -2.66127  -17.77139 9.66084   1.000 19.33451 ? 63  TRP A CB   1 
ATOM   1240 C  CG   . TRP A 1 63  ? -2.45775  -19.26492 9.90585   1.000 21.17722 ? 63  TRP A CG   1 
ATOM   1241 C  CD1  . TRP A 1 63  ? -3.25911  -20.27443 9.49085   1.000 22.27710 ? 63  TRP A CD1  1 
ATOM   1242 C  CD2  . TRP A 1 63  ? -1.44133  -19.86157 10.72154  1.000 21.69425 ? 63  TRP A CD2  1 
ATOM   1243 N  NE1  . TRP A 1 63  ? -2.78603  -21.48257 9.95656   1.000 24.51486 ? 63  TRP A NE1  1 
ATOM   1244 C  CE2  . TRP A 1 63  ? -1.68358  -21.24919 10.73208  1.000 23.24723 ? 63  TRP A CE2  1 
ATOM   1245 C  CE3  . TRP A 1 63  ? -0.35357  -19.35610 11.43616  1.000 22.19898 ? 63  TRP A CE3  1 
ATOM   1246 C  CZ2  . TRP A 1 63  ? -0.83620  -22.15319 11.41375  1.000 22.64668 ? 63  TRP A CZ2  1 
ATOM   1247 C  CZ3  . TRP A 1 63  ? 0.49352   -20.26496 12.10467  1.000 25.40198 ? 63  TRP A CZ3  1 
ATOM   1248 C  CH2  . TRP A 1 63  ? 0.22977   -21.62993 12.08240  1.000 25.82929 ? 63  TRP A CH2  1 
ATOM   1249 H  H    . TRP A 1 63  ? -4.96361  -17.75433 10.86687  1.000 22.06055 ? 63  TRP A H    1 
ATOM   1250 H  HA   . TRP A 1 63  ? -2.46569  -17.13894 11.64773  1.000 23.58971 ? 63  TRP A HA   1 
ATOM   1251 H  HB2  . TRP A 1 63  ? -3.32934  -17.66152 8.96620   1.000 23.20205 ? 63  TRP A HB2  1 
ATOM   1252 H  HB3  . TRP A 1 63  ? -1.81761  -17.38875 9.37324   1.000 23.20205 ? 63  TRP A HB3  1 
ATOM   1253 H  HD1  . TRP A 1 63  ? -4.01986  -20.16795 8.96662   1.000 26.73316 ? 63  TRP A HD1  1 
ATOM   1254 H  HE1  . TRP A 1 63  ? -3.12691  -22.25388 9.78779   1.000 29.41848 ? 63  TRP A HE1  1 
ATOM   1255 H  HE3  . TRP A 1 63  ? -0.19108  -18.44105 11.47070  1.000 26.63942 ? 63  TRP A HE3  1 
ATOM   1256 H  HZ2  . TRP A 1 63  ? -0.99993  -23.06863 11.40603  1.000 27.17665 ? 63  TRP A HZ2  1 
ATOM   1257 H  HZ3  . TRP A 1 63  ? 1.23648   -19.94758 12.56530  1.000 30.48301 ? 63  TRP A HZ3  1 
ATOM   1258 H  HH2  . TRP A 1 63  ? 0.80004   -22.20525 12.53923  1.000 30.99579 ? 63  TRP A HH2  1 
ATOM   1259 N  N    . CYS A 1 64  ? -4.42775  -15.04670 10.43552  1.000 19.97918 ? 64  CYS A N    1 
ATOM   1260 C  CA   . CYS A 1 64  ? -4.58767  -13.63932 10.12222  1.000 19.94737 ? 64  CYS A CA   1 
ATOM   1261 C  C    . CYS A 1 64  ? -5.92342  -13.15618 10.65901  1.000 18.74073 ? 64  CYS A C    1 
ATOM   1262 O  O    . CYS A 1 64  ? -6.81125  -13.94159 10.97607  1.000 21.62357 ? 64  CYS A O    1 
ATOM   1263 C  CB   . CYS A 1 64  ? -4.48627  -13.39632 8.60876   1.000 20.52770 ? 64  CYS A CB   1 
ATOM   1264 S  SG   . CYS A 1 64  ? -5.75996  -14.18412 7.58762   1.000 19.11747 ? 64  CYS A SG   1 
ATOM   1265 H  H    . CYS A 1 64  ? -5.16549  -15.48836 10.45191  1.000 23.97566 ? 64  CYS A H    1 
ATOM   1266 H  HA   . CYS A 1 64  ? -3.89189  -13.12638 10.56231  1.000 23.93749 ? 64  CYS A HA   1 
ATOM   1267 H  HB2  . CYS A 1 64  ? -4.54358  -12.44092 8.45118   1.000 24.63387 ? 64  CYS A HB2  1 
ATOM   1268 H  HB3  . CYS A 1 64  ? -3.62820  -13.73173 8.30526   1.000 24.63387 ? 64  CYS A HB3  1 
ATOM   1269 N  N    . ASN A 1 65  ? -6.02515  -11.83812 10.79801  1.000 20.27628 ? 65  ASN A N    1 
ATOM   1270 C  CA   . ASN A 1 65  ? -7.24246  -11.22073 11.30393  1.000 20.07799 ? 65  ASN A CA   1 
ATOM   1271 C  C    . ASN A 1 65  ? -8.06789  -10.61361 10.17682  1.000 18.62102 ? 65  ASN A C    1 
ATOM   1272 O  O    . ASN A 1 65  ? -7.57607  -9.74230  9.46567   1.000 18.85019 ? 65  ASN A O    1 
ATOM   1273 C  CB   . ASN A 1 65  ? -6.90501  -10.13374 12.31164  1.000 23.10149 ? 65  ASN A CB   1 
ATOM   1274 C  CG   . ASN A 1 65  ? -8.14290  -9.45788  12.80741  1.000 30.51304 ? 65  ASN A CG   1 
ATOM   1275 O  OD1  . ASN A 1 65  ? -9.04748  -10.13375 13.27276  1.000 31.98112 ? 65  ASN A OD1  1 
ATOM   1276 N  ND2  . ASN A 1 65  ? -8.22359  -8.14336  12.64995  1.000 40.81375 ? 65  ASN A ND2  1 
ATOM   1277 H  H    . ASN A 1 65  ? -5.39952  -11.28057 10.60481  1.000 24.33218 ? 65  ASN A H    1 
ATOM   1278 H  HA   . ASN A 1 65  ? -7.77498  -11.91720 11.71896  1.000 24.09423 ? 65  ASN A HA   1 
ATOM   1279 H  HB2  . ASN A 1 65  ? -6.44573  -10.52789 13.06967  1.000 27.72242 ? 65  ASN A HB2  1 
ATOM   1280 H  HB3  . ASN A 1 65  ? -6.33920  -9.46783  11.89054  1.000 27.72242 ? 65  ASN A HB3  1 
ATOM   1281 H  HD21 . ASN A 1 65  ? -7.57899  -7.71481  12.27520  1.000 48.97714 ? 65  ASN A HD21 1 
ATOM   1282 H  HD22 . ASN A 1 65  ? -8.92050  -7.71960  12.92259  1.000 48.97714 ? 65  ASN A HD22 1 
ATOM   1283 N  N    . ASP A 1 66  ? -9.32323  -11.06567 10.05297  1.000 19.38864 ? 66  ASP A N    1 
ATOM   1284 C  CA   . ASP A 1 66  ? -10.25775 -10.49730 9.08442   1.000 19.00938 ? 66  ASP A CA   1 
ATOM   1285 C  C    . ASP A 1 66  ? -11.44354 -9.80161  9.73154   1.000 20.97168 ? 66  ASP A C    1 
ATOM   1286 O  O    . ASP A 1 66  ? -12.32350 -9.33956  9.00874   1.000 22.26451 ? 66  ASP A O    1 
ATOM   1287 C  CB   . ASP A 1 66  ? -10.71960 -11.50475 8.01911   1.000 20.14016 ? 66  ASP A CB   1 
ATOM   1288 C  CG   . ASP A 1 66  ? -11.53669 -12.65133 8.55800   1.000 19.10002 ? 66  ASP A CG   1 
ATOM   1289 O  OD1  . ASP A 1 66  ? -11.90278 -12.70679 9.75906   1.000 19.86361 ? 66  ASP A OD1  1 
ATOM   1290 O  OD2  . ASP A 1 66  ? -11.86829 -13.54091 7.75002   1.000 18.90687 ? 66  ASP A OD2  1 
ATOM   1291 H  H    . ASP A 1 66  ? -9.65442  -11.70470 10.52366  1.000 23.26700 ? 66  ASP A H    1 
ATOM   1292 H  HA   . ASP A 1 66  ? -9.76399  -9.82950  8.58329   1.000 22.81190 ? 66  ASP A HA   1 
ATOM   1293 H  HB2  . ASP A 1 66  ? -11.26496 -11.03764 7.36697   1.000 24.16883 ? 66  ASP A HB2  1 
ATOM   1294 H  HB3  . ASP A 1 66  ? -9.93612  -11.88067 7.58812   1.000 24.16883 ? 66  ASP A HB3  1 
ATOM   1295 N  N    . GLY A 1 67  ? -11.47694 -9.71642  11.04633  1.000 22.93309 ? 67  GLY A N    1 
ATOM   1296 C  CA   . GLY A 1 67  ? -12.54213 -9.01189  11.75588  1.000 24.97044 ? 67  GLY A CA   1 
ATOM   1297 C  C    . GLY A 1 67  ? -13.87137 -9.71120  11.80470  1.000 27.44771 ? 67  GLY A C    1 
ATOM   1298 O  O    . GLY A 1 67  ? -14.83579 -9.14205  12.34495  1.000 31.86857 ? 67  GLY A O    1 
ATOM   1299 H  H    . GLY A 1 67  ? -10.88611 -10.06259 11.56659  1.000 27.52035 ? 67  GLY A H    1 
ATOM   1300 H  HA2  . GLY A 1 67  ? -12.25599 -8.86540  12.67106  1.000 29.96517 ? 67  GLY A HA2  1 
ATOM   1301 H  HA3  . GLY A 1 67  ? -12.68018 -8.15295  11.32684  1.000 29.96517 ? 67  GLY A HA3  1 
ATOM   1302 N  N    A ARG A 1 68  ? -13.98221 -10.92508 11.28151  0.706 21.31536 ? 68  ARG A N    1 
ATOM   1303 N  N    B ARG A 1 68  ? -13.96319 -10.93626 11.28843  0.294 21.51817 ? 68  ARG A N    1 
ATOM   1304 C  CA   A ARG A 1 68  ? -15.26632 -11.60977 11.29325  0.706 22.50005 ? 68  ARG A CA   1 
ATOM   1305 C  CA   B ARG A 1 68  ? -15.23155 -11.64356 11.20424  0.294 22.32724 ? 68  ARG A CA   1 
ATOM   1306 C  C    A ARG A 1 68  ? -15.15750 -13.09299 11.62908  0.706 24.23781 ? 68  ARG A C    1 
ATOM   1307 C  C    B ARG A 1 68  ? -15.07386 -13.13710 11.48243  0.294 24.66347 ? 68  ARG A C    1 
ATOM   1308 O  O    A ARG A 1 68  ? -16.09318 -13.84778 11.34711  0.706 28.98019 ? 68  ARG A O    1 
ATOM   1309 O  O    B ARG A 1 68  ? -15.86303 -13.94975 10.98918  0.294 28.71250 ? 68  ARG A O    1 
ATOM   1310 C  CB   A ARG A 1 68  ? -15.99297 -11.40393 9.97279   0.706 24.46162 ? 68  ARG A CB   1 
ATOM   1311 C  CB   B ARG A 1 68  ? -15.88927 -11.40356 9.84305   0.294 24.39834 ? 68  ARG A CB   1 
ATOM   1312 C  CG   A ARG A 1 68  ? -15.32440 -12.06092 8.80084   0.706 23.04387 ? 68  ARG A CG   1 
ATOM   1313 C  CG   B ARG A 1 68  ? -15.03228 -11.79939 8.64345   0.294 25.76180 ? 68  ARG A CG   1 
ATOM   1314 C  CD   A ARG A 1 68  ? -16.25155 -12.10514 7.61113   0.706 27.19143 ? 68  ARG A CD   1 
ATOM   1315 C  CD   B ARG A 1 68  ? -15.90693 -12.31840 7.50909   0.294 25.28648 ? 68  ARG A CD   1 
ATOM   1316 N  NE   A ARG A 1 68  ? -15.80765 -13.05984 6.60528   0.706 22.55627 ? 68  ARG A NE   1 
ATOM   1317 N  NE   B ARG A 1 68  ? -16.37292 -13.67623 7.77196   0.294 30.60129 ? 68  ARG A NE   1 
ATOM   1318 C  CZ   A ARG A 1 68  ? -16.22796 -13.05139 5.34685   0.706 22.14979 ? 68  ARG A CZ   1 
ATOM   1319 C  CZ   B ARG A 1 68  ? -17.60031 -14.11506 7.52488   0.294 30.38670 ? 68  ARG A CZ   1 
ATOM   1320 N  NH1  A ARG A 1 68  ? -17.11504 -12.16890 4.93539   0.706 24.07679 ? 68  ARG A NH1  1 
ATOM   1321 N  NH1  B ARG A 1 68  ? -18.51965 -13.33194 6.98678   0.294 31.14689 ? 68  ARG A NH1  1 
ATOM   1322 N  NH2  A ARG A 1 68  ? -15.78344 -13.98327 4.49219   0.706 20.94359 ? 68  ARG A NH2  1 
ATOM   1323 N  NH2  B ARG A 1 68  ? -17.91970 -15.36597 7.84731   0.294 19.77748 ? 68  ARG A NH2  1 
ATOM   1324 H  H    A ARG A 1 68  ? -13.33924 -11.36682 10.91948  0.706 25.57907 ? 68  ARG A H    1 
ATOM   1325 H  H    B ARG A 1 68  ? -13.29584 -11.38091 10.97774  0.294 25.82245 ? 68  ARG A H    1 
ATOM   1326 H  HA   A ARG A 1 68  ? -15.81190 -11.22139 11.99496  0.706 27.00070 ? 68  ARG A HA   1 
ATOM   1327 H  HA   B ARG A 1 68  ? -15.82729 -11.30029 11.88846  0.294 26.79333 ? 68  ARG A HA   1 
ATOM   1328 H  HB2  A ARG A 1 68  ? -16.88652 -11.77370 10.04852  0.706 29.35458 ? 68  ARG A HB2  1 
ATOM   1329 H  HB2  B ARG A 1 68  ? -16.70838 -11.92141 9.80079   0.294 29.27865 ? 68  ARG A HB2  1 
ATOM   1330 H  HB3  A ARG A 1 68  ? -16.04200 -10.45263 9.78972   0.706 29.35458 ? 68  ARG A HB3  1 
ATOM   1331 H  HB3  B ARG A 1 68  ? -16.08978 -10.45816 9.75988   0.294 29.27865 ? 68  ARG A HB3  1 
ATOM   1332 H  HG2  A ARG A 1 68  ? -14.53245 -11.55743 8.55544   0.706 27.65328 ? 68  ARG A HG2  1 
ATOM   1333 H  HG2  B ARG A 1 68  ? -14.54120 -11.02565 8.32555   0.294 30.91480 ? 68  ARG A HG2  1 
ATOM   1334 H  HG3  A ARG A 1 68  ? -15.08024 -12.97006 9.03484   0.706 27.65328 ? 68  ARG A HG3  1 
ATOM   1335 H  HG3  B ARG A 1 68  ? -14.41452 -12.50083 8.90281   0.294 30.91480 ? 68  ARG A HG3  1 
ATOM   1336 H  HD2  A ARG A 1 68  ? -17.13735 -12.36736 7.90693   0.706 32.63035 ? 68  ARG A HD2  1 
ATOM   1337 H  HD2  B ARG A 1 68  ? -16.68194 -11.74320 7.41212   0.294 30.34441 ? 68  ARG A HD2  1 
ATOM   1338 H  HD3  A ARG A 1 68  ? -16.28532 -11.22697 7.20055   0.706 32.63035 ? 68  ARG A HD3  1 
ATOM   1339 H  HD3  B ARG A 1 68  ? -15.39416 -12.32578 6.68573   0.294 30.34441 ? 68  ARG A HD3  1 
ATOM   1340 H  HE   A ARG A 1 68  ? -15.24131 -13.66295 6.84004   0.706 27.06816 ? 68  ARG A HE   1 
ATOM   1341 H  HE   B ARG A 1 68  ? -15.81134 -14.23202 8.11155   0.294 36.72218 ? 68  ARG A HE   1 
ATOM   1342 H  HH11 A ARG A 1 68  ? -17.43006 -11.58742 5.48515   0.706 28.89278 ? 68  ARG A HH11 1 
ATOM   1343 H  HH11 B ARG A 1 68  ? -18.32807 -12.51735 6.78845   0.294 37.37691 ? 68  ARG A HH11 1 
ATOM   1344 H  HH12 A ARG A 1 68  ? -17.37919 -12.17420 4.11698   0.706 28.89278 ? 68  ARG A HH12 1 
ATOM   1345 H  HH12 B ARG A 1 68  ? -19.30924 -13.63714 6.83511   0.294 37.37691 ? 68  ARG A HH12 1 
ATOM   1346 H  HH21 A ARG A 1 68  ? -15.22839 -14.58294 4.76039   0.706 25.13295 ? 68  ARG A HH21 1 
ATOM   1347 H  HH21 B ARG A 1 68  ? -17.33346 -15.87927 8.21126   0.294 23.73362 ? 68  ARG A HH21 1 
ATOM   1348 H  HH22 A ARG A 1 68  ? -16.05325 -13.98154 3.67562   0.706 25.13295 ? 68  ARG A HH22 1 
ATOM   1349 H  HH22 B ARG A 1 68  ? -18.71235 -15.66112 7.69174   0.294 23.73362 ? 68  ARG A HH22 1 
ATOM   1350 N  N    . THR A 1 69  ? -14.04943 -13.52281 12.24623  1.000 21.48013 ? 69  THR A N    1 
ATOM   1351 C  CA   . THR A 1 69  ? -13.83522 -14.92098 12.62354  1.000 20.91932 ? 69  THR A CA   1 
ATOM   1352 C  C    . THR A 1 69  ? -13.71371 -14.98293 14.14121  1.000 24.00131 ? 69  THR A C    1 
ATOM   1353 O  O    . THR A 1 69  ? -12.61383 -14.87201 14.68283  1.000 27.54075 ? 69  THR A O    1 
ATOM   1354 C  CB   . THR A 1 69  ? -12.58596 -15.49296 11.92954  1.000 21.45111 ? 69  THR A CB   1 
ATOM   1355 O  OG1  . THR A 1 69  ? -12.61161 -15.19281 10.51108  1.000 21.12247 ? 69  THR A OG1  1 
ATOM   1356 C  CG2  . THR A 1 69  ? -12.54190 -16.99519 12.10499  1.000 22.35195 ? 69  THR A CG2  1 
ATOM   1357 H  H    . THR A 1 69  ? -13.39330 -13.01008 12.46115  1.000 25.77679 ? 69  THR A H    1 
ATOM   1358 H  HA   . THR A 1 69  ? -14.59869 -15.45614 12.35593  1.000 25.10383 ? 69  THR A HA   1 
ATOM   1359 H  HB   . THR A 1 69  ? -11.79403 -15.09563 12.32436  1.000 25.74197 ? 69  THR A HB   1 
ATOM   1360 H  HG1  . THR A 1 69  ? -13.22821 -15.62377 10.13734  1.000 25.34761 ? 69  THR A HG1  1 
ATOM   1361 H  HG21 . THR A 1 69  ? -11.70419 -17.34472 11.76298  1.000 26.82298 ? 69  THR A HG21 1 
ATOM   1362 H  HG22 . THR A 1 69  ? -12.61709 -17.22175 13.04516  1.000 26.82298 ? 69  THR A HG22 1 
ATOM   1363 H  HG23 . THR A 1 69  ? -13.27543 -17.40725 11.62225  1.000 26.82298 ? 69  THR A HG23 1 
ATOM   1364 N  N    . PRO A 1 70  ? -14.82916 -15.07249 14.85692  1.000 26.49289 ? 70  PRO A N    1 
ATOM   1365 C  CA   . PRO A 1 70  ? -14.76658 -14.96292 16.32246  1.000 36.02307 ? 70  PRO A CA   1 
ATOM   1366 C  C    . PRO A 1 70  ? -13.93986 -16.06416 16.95775  1.000 36.57977 ? 70  PRO A C    1 
ATOM   1367 O  O    . PRO A 1 70  ? -13.98701 -17.22292 16.54611  1.000 40.11570 ? 70  PRO A O    1 
ATOM   1368 C  CB   . PRO A 1 70  ? -16.23818 -15.07267 16.74685  1.000 45.77990 ? 70  PRO A CB   1 
ATOM   1369 C  CG   . PRO A 1 70  ? -17.00615 -14.64722 15.55666  1.000 41.52789 ? 70  PRO A CG   1 
ATOM   1370 C  CD   . PRO A 1 70  ? -16.21755 -15.15446 14.37526  1.000 34.09321 ? 70  PRO A CD   1 
ATOM   1371 H  HA   . PRO A 1 70  ? -14.39755 -14.10075 16.57021  1.000 43.22833 ? 70  PRO A HA   1 
ATOM   1372 H  HB2  . PRO A 1 70  ? -16.44637 -15.98940 16.98596  1.000 54.93652 ? 70  PRO A HB2  1 
ATOM   1373 H  HB3  . PRO A 1 70  ? -16.41024 -14.48611 17.50001  1.000 54.93652 ? 70  PRO A HB3  1 
ATOM   1374 H  HG2  . PRO A 1 70  ? -17.89172 -15.04251 15.57691  1.000 49.83411 ? 70  PRO A HG2  1 
ATOM   1375 H  HG3  . PRO A 1 70  ? -17.07501 -13.67987 15.53702  1.000 49.83411 ? 70  PRO A HG3  1 
ATOM   1376 H  HD2  . PRO A 1 70  ? -16.45871 -16.06975 14.16316  1.000 40.91249 ? 70  PRO A HD2  1 
ATOM   1377 H  HD3  . PRO A 1 70  ? -16.35053 -14.58798 13.59917  1.000 40.91249 ? 70  PRO A HD3  1 
ATOM   1378 N  N    A GLY A 1 71  ? -13.21506 -15.69214 18.01199  0.706 37.47135 ? 71  GLY A N    1 
ATOM   1379 N  N    B GLY A 1 71  ? -13.14494 -15.68194 17.95097  0.294 38.02088 ? 71  GLY A N    1 
ATOM   1380 C  CA   A GLY A 1 71  ? -12.41291 -16.64669 18.74519  0.706 50.56320 ? 71  GLY A CA   1 
ATOM   1381 C  CA   B GLY A 1 71  ? -12.31465 -16.64319 18.65412  0.294 50.73553 ? 71  GLY A CA   1 
ATOM   1382 C  C    A GLY A 1 71  ? -11.18272 -17.11508 18.01550  0.706 45.65888 ? 71  GLY A C    1 
ATOM   1383 C  C    B GLY A 1 71  ? -11.17041 -17.20730 17.83828  0.294 45.77389 ? 71  GLY A C    1 
ATOM   1384 O  O    A GLY A 1 71  ? -10.48216 -18.00669 18.50593  0.706 48.94642 ? 71  GLY A O    1 
ATOM   1385 O  O    B GLY A 1 71  ? -10.87936 -18.40674 17.93995  0.294 49.11051 ? 71  GLY A O    1 
ATOM   1386 H  H    A GLY A 1 71  ? -13.17556 -14.88931 18.31776  0.706 44.96626 ? 71  GLY A H    1 
ATOM   1387 H  H    B GLY A 1 71  ? -13.07012 -14.87340 18.23428  0.294 45.62570 ? 71  GLY A H    1 
ATOM   1388 H  HA2  A GLY A 1 71  ? -12.12826 -16.24057 19.57882  0.706 60.67648 ? 71  GLY A HA2  1 
ATOM   1389 H  HA2  B GLY A 1 71  ? -11.93652 -16.21399 19.43751  0.294 60.88328 ? 71  GLY A HA2  1 
ATOM   1390 H  HA3  A GLY A 1 71  ? -12.95665 -17.42530 18.94270  0.706 60.67648 ? 71  GLY A HA3  1 
ATOM   1391 H  HA3  B GLY A 1 71  ? -12.87028 -17.38582 18.93815  0.294 60.88328 ? 71  GLY A HA3  1 
ATOM   1392 N  N    A SER A 1 72  ? -10.88337 -16.52771 16.86864  0.706 31.52895 ? 72  SER A N    1 
ATOM   1393 N  N    B SER A 1 72  ? -10.50864 -16.37482 17.03600  0.294 35.90201 ? 72  SER A N    1 
ATOM   1394 C  CA   A SER A 1 72  ? -9.78047  -16.99523 16.05022  0.706 36.08747 ? 72  SER A CA   1 
ATOM   1395 C  CA   B SER A 1 72  ? -9.35789  -16.78830 16.24179  0.294 36.62120 ? 72  SER A CA   1 
ATOM   1396 C  C    A SER A 1 72  ? -8.47861  -16.34387 16.50061  0.706 38.76929 ? 72  SER A C    1 
ATOM   1397 C  C    B SER A 1 72  ? -8.09123  -16.11506 16.76469  0.294 38.21097 ? 72  SER A C    1 
ATOM   1398 O  O    A SER A 1 72  ? -8.46709  -15.32524 17.20120  0.706 37.89757 ? 72  SER A O    1 
ATOM   1399 O  O    B SER A 1 72  ? -8.13471  -15.24640 17.63914  0.294 34.88755 ? 72  SER A O    1 
ATOM   1400 C  CB   A SER A 1 72  ? -10.06437 -16.66727 14.58737  0.706 30.76094 ? 72  SER A CB   1 
ATOM   1401 C  CB   B SER A 1 72  ? -9.58069  -16.47709 14.75784  0.294 34.36126 ? 72  SER A CB   1 
ATOM   1402 O  OG   A SER A 1 72  ? -9.86543  -15.29453 14.35680  0.706 32.16573 ? 72  SER A OG   1 
ATOM   1403 O  OG   B SER A 1 72  ? -9.62415  -15.08367 14.53272  0.294 33.00774 ? 72  SER A OG   1 
ATOM   1404 H  H    A SER A 1 72  ? -11.30628 -15.85382 16.54212  0.706 37.83538 ? 72  SER A H    1 
ATOM   1405 H  H    B SER A 1 72  ? -10.71432 -15.54601 16.93423  0.294 43.08305 ? 72  SER A H    1 
ATOM   1406 H  HA   A SER A 1 72  ? -9.67536  -17.95561 16.13690  0.706 43.30560 ? 72  SER A HA   1 
ATOM   1407 H  HA   B SER A 1 72  ? -9.23647  -17.74720 16.32336  0.294 43.94608 ? 72  SER A HA   1 
ATOM   1408 H  HB2  A SER A 1 72  ? -9.46181  -17.17657 14.02307  0.706 36.91377 ? 72  SER A HB2  1 
ATOM   1409 H  HB2  B SER A 1 72  ? -8.85109  -16.85659 14.24349  0.294 41.23415 ? 72  SER A HB2  1 
ATOM   1410 H  HB3  A SER A 1 72  ? -10.98433 -16.89572 14.38151  0.706 36.91377 ? 72  SER A HB3  1 
ATOM   1411 H  HB3  B SER A 1 72  ? -10.42294 -16.86787 14.47712  0.294 41.23415 ? 72  SER A HB3  1 
ATOM   1412 H  HG   A SER A 1 72  ? -10.59908 -14.92251 14.18665  0.706 38.59952 ? 72  SER A HG   1 
ATOM   1413 H  HG   B SER A 1 72  ? -10.33042 -14.76252 14.85468  0.294 39.60993 ? 72  SER A HG   1 
ATOM   1414 N  N    A ARG A 1 73  ? -7.36826  -16.95867 16.11322  0.661 25.54573 ? 73  ARG A N    1 
ATOM   1415 N  N    B ARG A 1 73  ? -6.94735  -16.51576 16.20280  0.339 25.68204 ? 73  ARG A N    1 
ATOM   1416 C  CA   A ARG A 1 73  ? -6.07647  -16.35179 16.37500  0.661 24.99339 ? 73  ARG A CA   1 
ATOM   1417 C  CA   B ARG A 1 73  ? -5.65476  -16.29468 16.84472  0.339 31.65120 ? 73  ARG A CA   1 
ATOM   1418 C  C    A ARG A 1 73  ? -5.57732  -15.60711 15.14339  0.661 26.83569 ? 73  ARG A C    1 
ATOM   1419 C  C    B ARG A 1 73  ? -4.82550  -15.17313 16.23203  0.339 32.69512 ? 73  ARG A C    1 
ATOM   1420 O  O    A ARG A 1 73  ? -6.17042  -15.64686 14.06405  0.661 27.45147 ? 73  ARG A O    1 
ATOM   1421 O  O    B ARG A 1 73  ? -4.26802  -14.35471 16.96714  0.339 41.59893 ? 73  ARG A O    1 
ATOM   1422 C  CB   A ARG A 1 73  ? -5.05056  -17.39227 16.83117  0.661 31.43679 ? 73  ARG A CB   1 
ATOM   1423 C  CB   B ARG A 1 73  ? -4.84914  -17.59554 16.83048  0.339 34.42573 ? 73  ARG A CB   1 
ATOM   1424 C  CG   A ARG A 1 73  ? -5.61974  -18.51020 17.70662  0.661 44.98849 ? 73  ARG A CG   1 
ATOM   1425 C  CG   B ARG A 1 73  ? -5.38842  -18.65882 17.76113  0.339 44.54892 ? 73  ARG A CG   1 
ATOM   1426 C  CD   A ARG A 1 73  ? -5.83510  -18.08924 19.15914  0.661 47.02575 ? 73  ARG A CD   1 
ATOM   1427 C  CD   B ARG A 1 73  ? -4.23877  -19.43167 18.37022  0.339 59.29391 ? 73  ARG A CD   1 
ATOM   1428 N  NE   A ARG A 1 73  ? -4.92652  -17.03905 19.61124  0.661 70.75193 ? 73  ARG A NE   1 
ATOM   1429 N  NE   B ARG A 1 73  ? -3.63031  -18.66545 19.45036  0.339 74.63777 ? 73  ARG A NE   1 
ATOM   1430 C  CZ   A ARG A 1 73  ? -3.73465  -17.25234 20.15604  0.661 78.51542 ? 73  ARG A CZ   1 
ATOM   1431 C  CZ   B ARG A 1 73  ? -2.60242  -19.07221 20.18101  0.339 74.95540 ? 73  ARG A CZ   1 
ATOM   1432 N  NH1  A ARG A 1 73  ? -3.26025  -18.47593 20.33198  0.661 78.20591 ? 73  ARG A NH1  1 
ATOM   1433 N  NH1  B ARG A 1 73  ? -2.03183  -20.24820 19.97992  0.339 69.13207 ? 73  ARG A NH1  1 
ATOM   1434 N  NH2  A ARG A 1 73  ? -2.99884  -16.21061 20.53608  0.661 70.53539 ? 73  ARG A NH2  1 
ATOM   1435 N  NH2  B ARG A 1 73  ? -2.12938  -18.27298 21.13323  0.339 68.00080 ? 73  ARG A NH2  1 
ATOM   1436 H  H    A ARG A 1 73  ? -7.34123  -17.71481 15.70441  0.661 30.65551 ? 73  ARG A H    1 
ATOM   1437 H  H    B ARG A 1 73  ? -6.89724  -16.92003 15.44540  0.339 30.81909 ? 73  ARG A H    1 
ATOM   1438 H  HA   A ARG A 1 73  ? -6.17820  -15.71214 17.09708  0.661 29.99271 ? 73  ARG A HA   1 
ATOM   1439 H  HA   B ARG A 1 73  ? -5.82717  -16.03426 17.76306  0.339 37.98208 ? 73  ARG A HA   1 
ATOM   1440 H  HB2  A ARG A 1 73  ? -4.66126  -17.80634 16.04511  0.661 37.72478 ? 73  ARG A HB2  1 
ATOM   1441 H  HB2  B ARG A 1 73  ? -4.85828  -17.95772 15.93068  0.339 41.31152 ? 73  ARG A HB2  1 
ATOM   1442 H  HB3  A ARG A 1 73  ? -4.36176  -16.94148 17.34424  0.661 37.72478 ? 73  ARG A HB3  1 
ATOM   1443 H  HB3  B ARG A 1 73  ? -3.93807  -17.40063 17.10041  0.339 41.31152 ? 73  ARG A HB3  1 
ATOM   1444 H  HG2  A ARG A 1 73  ? -6.47729  -18.78579 17.34669  0.661 53.98682 ? 73  ARG A HG2  1 
ATOM   1445 H  HG2  B ARG A 1 73  ? -5.89844  -18.24337 18.47400  0.339 53.45934 ? 73  ARG A HG2  1 
ATOM   1446 H  HG3  A ARG A 1 73  ? -5.00227  -19.25827 17.70233  0.661 53.98682 ? 73  ARG A HG3  1 
ATOM   1447 H  HG3  B ARG A 1 73  ? -5.95123  -19.27419 17.26568  0.339 53.45934 ? 73  ARG A HG3  1 
ATOM   1448 H  HD2  A ARG A 1 73  ? -6.74133  -17.75737 19.25667  0.661 56.43155 ? 73  ARG A HD2  1 
ATOM   1449 H  HD2  B ARG A 1 73  ? -4.56534  -20.27076 18.73103  0.339 71.15334 ? 73  ARG A HD2  1 
ATOM   1450 H  HD3  A ARG A 1 73  ? -5.70122  -18.86135 19.73083  0.661 56.43155 ? 73  ARG A HD3  1 
ATOM   1451 H  HD3  B ARG A 1 73  ? -3.56543  -19.60144 17.69296  0.339 71.15334 ? 73  ARG A HD3  1 
ATOM   1452 H  HE   A ARG A 1 73  ? -5.18204  -16.22322 19.51781  0.661 84.90296 ? 73  ARG A HE   1 
ATOM   1453 H  HE   B ARG A 1 73  ? -3.96294  -17.89221 19.62656  0.339 89.56597 ? 73  ARG A HE   1 
ATOM   1454 H  HH11 A ARG A 1 73  ? -3.72708  -19.15687 20.09113  0.661 93.84773 ? 73  ARG A HH11 1 
ATOM   1455 H  HH11 B ARG A 1 73  ? -2.32694  -20.76942 19.36280  0.339 82.95913 ? 73  ARG A HH11 1 
ATOM   1456 H  HH12 A ARG A 1 73  ? -2.48531  -18.58973 20.68710  0.661 93.84773 ? 73  ARG A HH12 1 
ATOM   1457 H  HH12 B ARG A 1 73  ? -1.36568  -20.49172 20.46627  0.339 82.95913 ? 73  ARG A HH12 1 
ATOM   1458 H  HH21 A ARG A 1 73  ? -3.29687  -15.41122 20.42764  0.661 84.64311 ? 73  ARG A HH21 1 
ATOM   1459 H  HH21 B ARG A 1 73  ? -2.49022  -17.50402 21.26774  0.339 81.60161 ? 73  ARG A HH21 1 
ATOM   1460 H  HH22 A ARG A 1 73  ? -2.22532  -16.33680 20.89011  0.661 84.64311 ? 73  ARG A HH22 1 
ATOM   1461 H  HH22 B ARG A 1 73  ? -1.46268  -18.52519 21.61438  0.339 81.60161 ? 73  ARG A HH22 1 
ATOM   1462 N  N    A ASN A 1 74  ? -4.46027  -14.91822 15.33752  0.706 24.55500 ? 74  ASN A N    1 
ATOM   1463 N  N    B ASN A 1 74  ? -4.70361  -15.12881 14.90895  0.294 22.70792 ? 74  ASN A N    1 
ATOM   1464 C  CA   A ASN A 1 74  ? -3.81292  -14.08652 14.34172  0.706 22.53389 ? 74  ASN A CA   1 
ATOM   1465 C  CA   B ASN A 1 74  ? -3.84724  -14.15714 14.22474  0.294 23.27253 ? 74  ASN A CA   1 
ATOM   1466 C  C    A ASN A 1 74  ? -2.30213  -14.33605 14.46776  0.706 23.50520 ? 74  ASN A C    1 
ATOM   1467 C  C    B ASN A 1 74  ? -2.36698  -14.38204 14.55874  0.294 23.63391 ? 74  ASN A C    1 
ATOM   1468 O  O    A ASN A 1 74  ? -1.49988  -13.44914 14.72764  0.706 24.54420 ? 74  ASN A O    1 
ATOM   1469 O  O    B ASN A 1 74  ? -1.67023  -13.50395 15.05966  0.294 27.45831 ? 74  ASN A O    1 
ATOM   1470 C  CB   A ASN A 1 74  ? -4.16162  -12.60560 14.50779  0.706 25.57844 ? 74  ASN A CB   1 
ATOM   1471 C  CB   B ASN A 1 74  ? -4.27128  -12.71147 14.50917  0.294 25.81883 ? 74  ASN A CB   1 
ATOM   1472 C  CG   A ASN A 1 74  ? -3.49958  -11.72702 13.46542  0.706 26.61430 ? 74  ASN A CG   1 
ATOM   1473 C  CG   B ASN A 1 74  ? -3.70069  -11.73313 13.50275  0.294 25.94853 ? 74  ASN A CG   1 
ATOM   1474 O  OD1  A ASN A 1 74  ? -2.93450  -12.21890 12.48969  0.706 25.74394 ? 74  ASN A OD1  1 
ATOM   1475 O  OD1  B ASN A 1 74  ? -3.00437  -12.12278 12.56280  0.294 25.55819 ? 74  ASN A OD1  1 
ATOM   1476 N  ND2  A ASN A 1 74  ? -3.54431  -10.41400 13.67326  0.706 29.47564 ? 74  ASN A ND2  1 
ATOM   1477 N  ND2  B ASN A 1 74  ? -3.98092  -10.45302 13.69836  0.294 30.62624 ? 74  ASN A ND2  1 
ATOM   1478 H  H    A ASN A 1 74  ? -4.03486  -14.91868 16.08494  0.706 29.46664 ? 74  ASN A H    1 
ATOM   1479 H  H    B ASN A 1 74  ? -5.11427  -15.66106 14.37260  0.294 27.25014 ? 74  ASN A H    1 
ATOM   1480 H  HA   A ASN A 1 74  ? -4.11819  -14.33956 13.45646  0.706 27.04131 ? 74  ASN A HA   1 
ATOM   1481 H  HA   B ASN A 1 74  ? -3.95546  -14.30405 13.27206  0.294 27.92767 ? 74  ASN A HA   1 
ATOM   1482 H  HB2  A ASN A 1 74  ? -5.12196  -12.49591 14.42638  0.706 30.69477 ? 74  ASN A HB2  1 
ATOM   1483 H  HB2  B ASN A 1 74  ? -5.23873  -12.65147 14.47267  0.294 30.98324 ? 74  ASN A HB2  1 
ATOM   1484 H  HB3  A ASN A 1 74  ? -3.86663  -12.30754 15.38245  0.706 30.69477 ? 74  ASN A HB3  1 
ATOM   1485 H  HB3  B ASN A 1 74  ? -3.95603  -12.45575 15.39015  0.294 30.98324 ? 74  ASN A HB3  1 
ATOM   1486 H  HD21 A ASN A 1 74  ? -3.18179  -9.87659  13.10813  0.706 35.37141 ? 74  ASN A HD21 1 
ATOM   1487 H  HD21 B ASN A 1 74  ? -3.67994  -9.85893  13.15425  0.294 36.75212 ? 74  ASN A HD21 1 
ATOM   1488 H  HD22 A ASN A 1 74  ? -3.93574  -10.10246 14.37278  0.706 35.37141 ? 74  ASN A HD22 1 
ATOM   1489 H  HD22 B ASN A 1 74  ? -4.46380  -10.21622 14.36945  0.294 36.75212 ? 74  ASN A HD22 1 
ATOM   1490 N  N    . LEU A 1 75  ? -1.89428  -15.58689 14.24830  1.000 23.30942 ? 75  LEU A N    1 
ATOM   1491 C  CA   . LEU A 1 75  ? -0.52284  -15.98685 14.57173  1.000 24.69439 ? 75  LEU A CA   1 
ATOM   1492 C  C    . LEU A 1 75  ? 0.52306   -15.35072 13.66167  1.000 25.60561 ? 75  LEU A C    1 
ATOM   1493 O  O    . LEU A 1 75  ? 1.70096   -15.27212 14.04695  1.000 28.93722 ? 75  LEU A O    1 
ATOM   1494 C  CB   . LEU A 1 75  ? -0.46362  -17.51353 14.50910  1.000 27.52370 ? 75  LEU A CB   1 
ATOM   1495 C  CG   . LEU A 1 75  ? -1.03987  -18.19065 15.75747  1.000 31.11907 ? 75  LEU A CG   1 
ATOM   1496 C  CD1  . LEU A 1 75  ? -1.02118  -19.68879 15.62342  1.000 34.92291 ? 75  LEU A CD1  1 
ATOM   1497 C  CD2  . LEU A 1 75  ? -0.30493  -17.74965 17.04505  1.000 42.03300 ? 75  LEU A CD2  1 
ATOM   1498 H  H    . LEU A 1 75  ? -2.38302  -16.21306 13.91868  1.000 27.97194 ? 75  LEU A H    1 
ATOM   1499 H  HA   . LEU A 1 75  ? -0.28670  -15.69961 15.46763  1.000 29.63391 ? 75  LEU A HA   1 
ATOM   1500 H  HB2  . LEU A 1 75  ? -0.97432  -17.81587 13.74185  1.000 33.02908 ? 75  LEU A HB2  1 
ATOM   1501 H  HB3  . LEU A 1 75  ? 0.46249   -17.78797 14.42022  1.000 33.02908 ? 75  LEU A HB3  1 
ATOM   1502 H  HG   . LEU A 1 75  ? -1.96414  -17.90878 15.84218  1.000 37.34352 ? 75  LEU A HG   1 
ATOM   1503 H  HD11 . LEU A 1 75  ? -1.36359  -20.08328 16.44075  1.000 41.90813 ? 75  LEU A HD11 1 
ATOM   1504 H  HD12 . LEU A 1 75  ? -1.57949  -19.94569 14.87296  1.000 41.90813 ? 75  LEU A HD12 1 
ATOM   1505 H  HD13 . LEU A 1 75  ? -0.10868  -19.98095 15.47212  1.000 41.90813 ? 75  LEU A HD13 1 
ATOM   1506 H  HD21 . LEU A 1 75  ? -0.61037  -18.29616 17.78595  1.000 50.44024 ? 75  LEU A HD21 1 
ATOM   1507 H  HD22 . LEU A 1 75  ? 0.64980   -17.86641 16.91947  1.000 50.44024 ? 75  LEU A HD22 1 
ATOM   1508 H  HD23 . LEU A 1 75  ? -0.50404  -16.81626 17.21839  1.000 50.44024 ? 75  LEU A HD23 1 
ATOM   1509 N  N    . CYS A 1 76  ? 0.15455   -14.92077 12.44593  1.000 22.44778 ? 76  CYS A N    1 
ATOM   1510 C  CA   . CYS A 1 76  ? 1.06918   -14.17812 11.58978  1.000 22.13769 ? 76  CYS A CA   1 
ATOM   1511 C  C    . CYS A 1 76  ? 1.03635   -12.67299 11.84021  1.000 22.96921 ? 76  CYS A C    1 
ATOM   1512 O  O    . CYS A 1 76  ? 1.82987   -11.93738 11.23089  1.000 25.53380 ? 76  CYS A O    1 
ATOM   1513 C  CB   . CYS A 1 76  ? 0.82118   -14.48548 10.11130  1.000 22.27355 ? 76  CYS A CB   1 
ATOM   1514 S  SG   . CYS A 1 76  ? 1.29768   -16.20473 9.72589   1.000 23.47503 ? 76  CYS A SG   1 
ATOM   1515 H  H    . CYS A 1 76  ? -0.62253  -15.05084 12.10122  1.000 26.93797 ? 76  CYS A H    1 
ATOM   1516 H  HA   . CYS A 1 76  ? 1.97033   -14.48163 11.78136  1.000 26.56587 ? 76  CYS A HA   1 
ATOM   1517 H  HB2  . CYS A 1 76  ? -0.12108  -14.37275 9.91048   1.000 26.72890 ? 76  CYS A HB2  1 
ATOM   1518 H  HB3  . CYS A 1 76  ? 1.35132   -13.88664 9.56244   1.000 26.72890 ? 76  CYS A HB3  1 
ATOM   1519 N  N    A ASN A 1 77  ? 0.13618   -12.20569 12.71222  0.450 24.73275 ? 77  ASN A N    1 
ATOM   1520 N  N    B ASN A 1 77  ? 0.13641   -12.20519 12.70781  0.550 24.71976 ? 77  ASN A N    1 
ATOM   1521 C  CA   A ASN A 1 77  ? 0.06270   -10.80302 13.12460  0.450 26.69875 ? 77  ASN A CA   1 
ATOM   1522 C  CA   B ASN A 1 77  ? 0.06690   -10.80375 13.11656  0.550 26.64837 ? 77  ASN A CA   1 
ATOM   1523 C  C    A ASN A 1 77  ? -0.11563  -9.87126  11.92574  0.450 28.20181 ? 77  ASN A C    1 
ATOM   1524 C  C    B ASN A 1 77  ? -0.11729  -9.86961  11.92313  0.550 28.21535 ? 77  ASN A C    1 
ATOM   1525 O  O    A ASN A 1 77  ? 0.60899   -8.88836  11.75124  0.450 29.27183 ? 77  ASN A O    1 
ATOM   1526 O  O    B ASN A 1 77  ? 0.60240   -8.88189  11.74922  0.550 29.27802 ? 77  ASN A O    1 
ATOM   1527 C  CB   A ASN A 1 77  ? 1.27513   -10.40946 13.97870  0.450 32.91307 ? 77  ASN A CB   1 
ATOM   1528 C  CB   B ASN A 1 77  ? 1.28278   -10.40286 13.95513  0.550 32.92852 ? 77  ASN A CB   1 
ATOM   1529 C  CG   A ASN A 1 77  ? 1.37487   -11.22227 15.25885  0.450 36.79005 ? 77  ASN A CG   1 
ATOM   1530 C  CG   B ASN A 1 77  ? 1.02022   -9.16537  14.77521  0.550 32.71817 ? 77  ASN A CG   1 
ATOM   1531 O  OD1  A ASN A 1 77  ? 2.33534   -11.96942 15.45924  0.450 43.90517 ? 77  ASN A OD1  1 
ATOM   1532 O  OD1  B ASN A 1 77  ? -0.05604  -9.01560  15.35555  0.550 42.63486 ? 77  ASN A OD1  1 
ATOM   1533 N  ND2  A ASN A 1 77  ? 0.37732   -11.08516 16.13083  0.450 42.50038 ? 77  ASN A ND2  1 
ATOM   1534 N  ND2  B ASN A 1 77  ? 2.00011   -8.27090  14.83301  0.550 44.42004 ? 77  ASN A ND2  1 
ATOM   1535 H  H    A ASN A 1 77  ? -0.45985  -12.69791 13.08915  0.450 29.67994 ? 77  ASN A H    1 
ATOM   1536 H  H    B ASN A 1 77  ? -0.46161  -12.69575 13.08373  0.550 29.66435 ? 77  ASN A H    1 
ATOM   1537 H  HA   A ASN A 1 77  ? -0.72693  -10.69383 13.67728  0.450 32.03915 ? 77  ASN A HA   1 
ATOM   1538 H  HA   B ASN A 1 77  ? -0.72041  -10.70228 13.67401  0.550 31.97868 ? 77  ASN A HA   1 
ATOM   1539 H  HB2  A ASN A 1 77  ? 2.08516   -10.55588 13.46556  0.450 39.49633 ? 77  ASN A HB2  1 
ATOM   1540 H  HB2  B ASN A 1 77  ? 1.50486   -11.12677 14.56137  0.550 39.51486 ? 77  ASN A HB2  1 
ATOM   1541 H  HB3  A ASN A 1 77  ? 1.20104   -9.47334  14.22178  0.450 39.49633 ? 77  ASN A HB3  1 
ATOM   1542 H  HB3  B ASN A 1 77  ? 2.03152   -10.22248 13.36542  0.550 39.51486 ? 77  ASN A HB3  1 
ATOM   1543 H  HD21 A ASN A 1 77  ? -0.27827  -10.55718 15.95466  0.450 51.00110 ? 77  ASN A HD21 1 
ATOM   1544 H  HD21 B ASN A 1 77  ? 2.73789   -8.41370  14.41480  0.550 53.30469 ? 77  ASN A HD21 1 
ATOM   1545 H  HD22 A ASN A 1 77  ? 0.38886   -11.52461 16.86998  0.450 51.00110 ? 77  ASN A HD22 1 
ATOM   1546 H  HD22 B ASN A 1 77  ? 1.89690   -7.54886  15.28864  0.550 53.30469 ? 77  ASN A HD22 1 
ATOM   1547 N  N    . ILE A 1 78  ? -1.10428  -10.18815 11.08882  1.000 24.86792 ? 78  ILE A N    1 
ATOM   1548 C  CA   . ILE A 1 78  ? -1.34466  -9.43271  9.86649   1.000 24.76252 ? 78  ILE A CA   1 
ATOM   1549 C  C    . ILE A 1 78  ? -2.83417  -9.40936  9.55712   1.000 21.46643 ? 78  ILE A C    1 
ATOM   1550 O  O    . ILE A 1 78  ? -3.55073  -10.37090 9.84699   1.000 22.91078 ? 78  ILE A O    1 
ATOM   1551 C  CB   . ILE A 1 78  ? -0.63842  -10.04560 8.63837   1.000 24.78408 ? 78  ILE A CB   1 
ATOM   1552 C  CG1  . ILE A 1 78  ? -0.92806  -11.53751 8.55265   1.000 26.17193 ? 78  ILE A CG1  1 
ATOM   1553 C  CG2  . ILE A 1 78  ? 0.84863   -9.71951  8.63267   1.000 35.11963 ? 78  ILE A CG2  1 
ATOM   1554 C  CD1  . ILE A 1 78  ? -0.66762  -12.12937 7.16605   1.000 44.44002 ? 78  ILE A CD1  1 
ATOM   1555 H  H    . ILE A 1 78  ? -1.65091  -10.84099 11.20965  1.000 29.84215 ? 78  ILE A H    1 
ATOM   1556 H  HA   . ILE A 1 78  ? -1.01079  -8.53805  10.03682  1.000 29.71566 ? 78  ILE A HA   1 
ATOM   1557 H  HB   . ILE A 1 78  ? -1.00119  -9.64087  7.83495   1.000 29.74153 ? 78  ILE A HB   1 
ATOM   1558 H  HG12 . ILE A 1 78  ? -0.36048  -12.00356 9.18633   1.000 31.40695 ? 78  ILE A HG12 1 
ATOM   1559 H  HG13 . ILE A 1 78  ? -1.86133  -11.68826 8.76985   1.000 31.40695 ? 78  ILE A HG13 1 
ATOM   1560 H  HG21 . ILE A 1 78  ? 1.25144   -10.09602 7.83462   1.000 42.14420 ? 78  ILE A HG21 1 
ATOM   1561 H  HG22 . ILE A 1 78  ? 0.96067   -8.75601  8.63670   1.000 42.14420 ? 78  ILE A HG22 1 
ATOM   1562 H  HG23 . ILE A 1 78  ? 1.25919   -10.10357 9.42314   1.000 42.14420 ? 78  ILE A HG23 1 
ATOM   1563 H  HD11 . ILE A 1 78  ? -0.87669  -13.07642 7.18257   1.000 53.32866 ? 78  ILE A HD11 1 
ATOM   1564 H  HD12 . ILE A 1 78  ? -1.23131  -11.67743 6.51882   1.000 53.32866 ? 78  ILE A HD12 1 
ATOM   1565 H  HD13 . ILE A 1 78  ? 0.26640   -12.00074 6.93812   1.000 53.32866 ? 78  ILE A HD13 1 
ATOM   1566 N  N    . PRO A 1 79  ? -3.33729  -8.34812  8.95084   1.000 21.96023 ? 79  PRO A N    1 
ATOM   1567 C  CA   . PRO A 1 79  ? -4.69608  -8.41458  8.41315   1.000 20.38631 ? 79  PRO A CA   1 
ATOM   1568 C  C    . PRO A 1 79  ? -4.71770  -9.37262  7.22550   1.000 19.50084 ? 79  PRO A C    1 
ATOM   1569 O  O    . PRO A 1 79  ? -3.79008  -9.40388  6.41009   1.000 20.66958 ? 79  PRO A O    1 
ATOM   1570 C  CB   . PRO A 1 79  ? -4.98906  -6.96631  8.00809   1.000 23.61942 ? 79  PRO A CB   1 
ATOM   1571 C  CG   . PRO A 1 79  ? -3.67255  -6.33690  7.81847   1.000 32.90982 ? 79  PRO A CG   1 
ATOM   1572 C  CD   . PRO A 1 79  ? -2.68159  -7.05634  8.67275   1.000 25.46799 ? 79  PRO A CD   1 
ATOM   1573 H  HA   . PRO A 1 79  ? -5.35081  -8.68364  9.07635   1.000 24.46422 ? 79  PRO A HA   1 
ATOM   1574 H  HB2  . PRO A 1 79  ? -5.50002  -6.95317  7.18369   1.000 28.34394 ? 79  PRO A HB2  1 
ATOM   1575 H  HB3  . PRO A 1 79  ? -5.48563  -6.52245  8.71329   1.000 28.34394 ? 79  PRO A HB3  1 
ATOM   1576 H  HG2  . PRO A 1 79  ? -3.42033  -6.40456  6.88428   1.000 39.49242 ? 79  PRO A HG2  1 
ATOM   1577 H  HG3  . PRO A 1 79  ? -3.72602  -5.40463  8.08099   1.000 39.49242 ? 79  PRO A HG3  1 
ATOM   1578 H  HD2  . PRO A 1 79  ? -1.84789  -7.18937  8.19511   1.000 30.56222 ? 79  PRO A HD2  1 
ATOM   1579 H  HD3  . PRO A 1 79  ? -2.51850  -6.56903  9.49544   1.000 30.56222 ? 79  PRO A HD3  1 
ATOM   1580 N  N    . CYS A 1 80  ? -5.80297  -10.12137 7.11992   1.000 19.09250 ? 80  CYS A N    1 
ATOM   1581 C  CA   . CYS A 1 80  ? -5.91244  -11.09596 6.03350   1.000 17.90096 ? 80  CYS A CA   1 
ATOM   1582 C  C    . CYS A 1 80  ? -5.83676  -10.41346 4.67293   1.000 18.59555 ? 80  CYS A C    1 
ATOM   1583 O  O    . CYS A 1 80  ? -5.33609  -11.00948 3.70277   1.000 19.60680 ? 80  CYS A O    1 
ATOM   1584 C  CB   . CYS A 1 80  ? -7.21074  -11.89063 6.16425   1.000 18.48204 ? 80  CYS A CB   1 
ATOM   1585 S  SG   . CYS A 1 80  ? -7.31692  -12.88265 7.69095   1.000 18.39089 ? 80  CYS A SG   1 
ATOM   1586 H  H    . CYS A 1 80  ? -6.47975  -10.09054 7.64966   1.000 22.91163 ? 80  CYS A H    1 
ATOM   1587 H  HA   . CYS A 1 80  ? -5.17682  -11.72492 6.09805   1.000 21.48180 ? 80  CYS A HA   1 
ATOM   1588 H  HB2  . CYS A 1 80  ? -7.95686  -11.27080 6.16161   1.000 22.17909 ? 80  CYS A HB2  1 
ATOM   1589 H  HB3  . CYS A 1 80  ? -7.28130  -12.49797 5.41122   1.000 22.17909 ? 80  CYS A HB3  1 
ATOM   1590 N  N    . SER A 1 81  ? -6.32393  -9.17016  4.57052   1.000 19.26043 ? 81  SER A N    1 
ATOM   1591 C  CA   . SER A 1 81  ? -6.23984  -8.43978  3.30724   1.000 20.53827 ? 81  SER A CA   1 
ATOM   1592 C  C    . SER A 1 81  ? -4.81021  -8.28183  2.79895   1.000 20.08101 ? 81  SER A C    1 
ATOM   1593 O  O    . SER A 1 81  ? -4.59816  -8.18279  1.58196   1.000 24.18546 ? 81  SER A O    1 
ATOM   1594 C  CB   . SER A 1 81  ? -6.91398  -7.06058  3.43302   1.000 23.38976 ? 81  SER A CB   1 
ATOM   1595 O  OG   . SER A 1 81  ? -6.23725  -6.24563  4.37323   1.000 27.17724 ? 81  SER A OG   1 
ATOM   1596 H  H    . SER A 1 81  ? -6.70175  -8.73578  5.20940   1.000 23.11316 ? 81  SER A H    1 
ATOM   1597 H  HA   . SER A 1 81  ? -6.72364  -8.95667  2.64416   1.000 24.64657 ? 81  SER A HA   1 
ATOM   1598 H  HB2  . SER A 1 81  ? -6.89800  -6.62246  2.56775   1.000 28.06835 ? 81  SER A HB2  1 
ATOM   1599 H  HB3  . SER A 1 81  ? -7.83055  -7.18387  3.72558   1.000 28.06835 ? 81  SER A HB3  1 
ATOM   1600 H  HG   . SER A 1 81  ? -6.56593  -6.35608  5.13832   1.000 32.61332 ? 81  SER A HG   1 
ATOM   1601 N  N    . ALA A 1 82  ? -3.81903  -8.23831  3.68415   1.000 19.43341 ? 82  ALA A N    1 
ATOM   1602 C  CA   . ALA A 1 82  ? -2.43439  -8.15735  3.24126   1.000 23.87494 ? 82  ALA A CA   1 
ATOM   1603 C  C    . ALA A 1 82  ? -2.00849  -9.36242  2.42681   1.000 23.16641 ? 82  ALA A C    1 
ATOM   1604 O  O    . ALA A 1 82  ? -1.03428  -9.27719  1.66520   1.000 28.39224 ? 82  ALA A O    1 
ATOM   1605 C  CB   . ALA A 1 82  ? -1.49406  -8.06633  4.43544   1.000 27.36774 ? 82  ALA A CB   1 
ATOM   1606 H  H    . ALA A 1 82  ? -3.92121  -8.25414  4.53791   1.000 23.32073 ? 82  ALA A H    1 
ATOM   1607 H  HA   . ALA A 1 82  ? -2.35597  -7.35559  2.70094   1.000 28.65057 ? 82  ALA A HA   1 
ATOM   1608 H  HB1  . ALA A 1 82  ? -0.58174  -7.99318  4.11415   1.000 32.84193 ? 82  ALA A HB1  1 
ATOM   1609 H  HB2  . ALA A 1 82  ? -1.72400  -7.28312  4.95948   1.000 32.84193 ? 82  ALA A HB2  1 
ATOM   1610 H  HB3  . ALA A 1 82  ? -1.59137  -8.86605  4.97569   1.000 32.84193 ? 82  ALA A HB3  1 
ATOM   1611 N  N    . LEU A 1 83  ? -2.68523  -10.48596 2.58241   1.000 21.01226 ? 83  LEU A N    1 
ATOM   1612 C  CA   . LEU A 1 83  ? -2.36398  -11.69883 1.84585   1.000 19.91279 ? 83  LEU A CA   1 
ATOM   1613 C  C    . LEU A 1 83  ? -2.89930  -11.69453 0.42060   1.000 24.42490 ? 83  LEU A C    1 
ATOM   1614 O  O    . LEU A 1 83  ? -2.68178  -12.66965 -0.31476  1.000 25.00273 ? 83  LEU A O    1 
ATOM   1615 C  CB   . LEU A 1 83  ? -2.92385  -12.89344 2.60449   1.000 21.38100 ? 83  LEU A CB   1 
ATOM   1616 C  CG   . LEU A 1 83  ? -2.41008  -13.01327 4.03028   1.000 23.52711 ? 83  LEU A CG   1 
ATOM   1617 C  CD1  . LEU A 1 83  ? -3.17478  -14.08523 4.77613   1.000 24.20914 ? 83  LEU A CD1  1 
ATOM   1618 C  CD2  . LEU A 1 83  ? -0.90701  -13.35299 3.99197   1.000 30.89753 ? 83  LEU A CD2  1 
ATOM   1619 H  H    . LEU A 1 83  ? -3.35029  -10.57602 3.12017   1.000 25.21535 ? 83  LEU A H    1 
ATOM   1620 H  HA   . LEU A 1 83  ? -1.40029  -11.79120 1.78540   1.000 23.89599 ? 83  LEU A HA   1 
ATOM   1621 H  HB2  . LEU A 1 83  ? -3.88962  -12.81175 2.64354   1.000 25.65784 ? 83  LEU A HB2  1 
ATOM   1622 H  HB3  . LEU A 1 83  ? -2.67833  -13.70425 2.13205   1.000 25.65784 ? 83  LEU A HB3  1 
ATOM   1623 H  HG   . LEU A 1 83  ? -2.53670  -12.17582 4.50309   1.000 28.23317 ? 83  LEU A HG   1 
ATOM   1624 H  HD11 . LEU A 1 83  ? -2.78225  -14.19899 5.65583   1.000 29.05161 ? 83  LEU A HD11 1 
ATOM   1625 H  HD12 . LEU A 1 83  ? -4.10150  -13.81138 4.86032   1.000 29.05161 ? 83  LEU A HD12 1 
ATOM   1626 H  HD13 . LEU A 1 83  ? -3.11931  -14.91640 4.27917   1.000 29.05161 ? 83  LEU A HD13 1 
ATOM   1627 H  HD21 . LEU A 1 83  ? -0.66866  -13.82317 4.80623   1.000 37.07768 ? 83  LEU A HD21 1 
ATOM   1628 H  HD22 . LEU A 1 83  ? -0.72981  -13.91504 3.22151   1.000 37.07768 ? 83  LEU A HD22 1 
ATOM   1629 H  HD23 . LEU A 1 83  ? -0.39875  -12.52956 3.92462   1.000 37.07768 ? 83  LEU A HD23 1 
ATOM   1630 N  N    . LEU A 1 84  ? -3.62263  -10.65674 0.00549   1.000 20.44976 ? 84  LEU A N    1 
ATOM   1631 C  CA   . LEU A 1 84  ? -4.16426  -10.58970 -1.33866  1.000 21.59514 ? 84  LEU A CA   1 
ATOM   1632 C  C    . LEU A 1 84  ? -3.34392  -9.69948  -2.25738  1.000 23.08639 ? 84  LEU A C    1 
ATOM   1633 O  O    . LEU A 1 84  ? -3.68172  -9.56670  -3.44413  1.000 27.22054 ? 84  LEU A O    1 
ATOM   1634 C  CB   . LEU A 1 84  ? -5.61966  -10.12525 -1.31611  1.000 21.74899 ? 84  LEU A CB   1 
ATOM   1635 C  CG   . LEU A 1 84  ? -6.49534  -10.88610 -0.32874  1.000 22.39266 ? 84  LEU A CG   1 
ATOM   1636 C  CD1  . LEU A 1 84  ? -7.86704  -10.26961 -0.20390  1.000 32.02791 ? 84  LEU A CD1  1 
ATOM   1637 C  CD2  . LEU A 1 84  ? -6.62035  -12.31561 -0.73505  1.000 22.42435 ? 84  LEU A CD2  1 
ATOM   1638 H  H    . LEU A 1 84  ? -3.81235  -9.97444  0.49343   1.000 24.54036 ? 84  LEU A H    1 
ATOM   1639 H  HA   . LEU A 1 84  ? -4.16119  -11.48414 -1.71399  1.000 25.91481 ? 84  LEU A HA   1 
ATOM   1640 H  HB2  . LEU A 1 84  ? -5.64252  -9.18716  -1.07039  1.000 26.09943 ? 84  LEU A HB2  1 
ATOM   1641 H  HB3  . LEU A 1 84  ? -5.99784  -10.24568 -2.20119  1.000 26.09943 ? 84  LEU A HB3  1 
ATOM   1642 H  HG   . LEU A 1 84  ? -6.07042  -10.83925 0.54198   1.000 26.87183 ? 84  LEU A HG   1 
ATOM   1643 H  HD11 . LEU A 1 84  ? -8.39166  -10.79096 0.42368   1.000 38.43413 ? 84  LEU A HD11 1 
ATOM   1644 H  HD12 . LEU A 1 84  ? -7.77593  -9.35896  0.11753   1.000 38.43413 ? 84  LEU A HD12 1 
ATOM   1645 H  HD13 . LEU A 1 84  ? -8.29471  -10.27185 -1.07452  1.000 38.43413 ? 84  LEU A HD13 1 
ATOM   1646 H  HD21 . LEU A 1 84  ? -7.21207  -12.76962 -0.11485  1.000 26.90986 ? 84  LEU A HD21 1 
ATOM   1647 H  HD22 . LEU A 1 84  ? -6.98615  -12.35803 -1.63243  1.000 26.90986 ? 84  LEU A HD22 1 
ATOM   1648 H  HD23 . LEU A 1 84  ? -5.74225  -12.72729 -0.71599  1.000 26.90986 ? 84  LEU A HD23 1 
ATOM   1649 N  N    . SER A 1 85  ? -2.27135  -9.12719  -1.74161  1.000 22.91527 ? 85  SER A N    1 
ATOM   1650 C  CA   . SER A 1 85  ? -1.43819  -8.21269  -2.49789  1.000 23.98644 ? 85  SER A CA   1 
ATOM   1651 C  C    . SER A 1 85  ? -0.75709  -8.88193  -3.68229  1.000 28.00437 ? 85  SER A C    1 
ATOM   1652 O  O    . SER A 1 85  ? -0.46353  -10.08139 -3.67679  1.000 28.66119 ? 85  SER A O    1 
ATOM   1653 C  CB   . SER A 1 85  ? -0.37986  -7.67242  -1.53979  1.000 26.45859 ? 85  SER A CB   1 
ATOM   1654 O  OG   . SER A 1 85  ? 0.53872   -6.83744  -2.21507  1.000 32.45556 ? 85  SER A OG   1 
ATOM   1655 H  H    . SER A 1 85  ? -1.99689  -9.25417  -0.93653  1.000 27.49897 ? 85  SER A H    1 
ATOM   1656 H  HA   . SER A 1 85  ? -1.98110  -7.49880  -2.86737  1.000 28.78437 ? 85  SER A HA   1 
ATOM   1657 H  HB2  . SER A 1 85  ? -0.81846  -7.15927  -0.84321  1.000 31.75095 ? 85  SER A HB2  1 
ATOM   1658 H  HB3  . SER A 1 85  ? 0.10134   -8.41856  -1.14912  1.000 31.75095 ? 85  SER A HB3  1 
ATOM   1659 H  HG   . SER A 1 85  ? 1.22106   -6.71768  -1.74003  1.000 38.94731 ? 85  SER A HG   1 
ATOM   1660 N  N    . SER A 1 86  ? -0.44509  -8.07466  -4.70074  1.000 27.11294 ? 86  SER A N    1 
ATOM   1661 C  CA   . SER A 1 86  ? 0.37262   -8.57695  -5.79166  1.000 24.73841 ? 86  SER A CA   1 
ATOM   1662 C  C    . SER A 1 86  ? 1.80088   -8.87633  -5.34987  1.000 26.03495 ? 86  SER A C    1 
ATOM   1663 O  O    . SER A 1 86  ? 2.49907   -9.63309  -6.03800  1.000 30.89122 ? 86  SER A O    1 
ATOM   1664 C  CB   . SER A 1 86  ? 0.41866   -7.55094  -6.92509  1.000 32.49268 ? 86  SER A CB   1 
ATOM   1665 O  OG   . SER A 1 86  ? 0.76672   -6.27312  -6.41902  1.000 46.10529 ? 86  SER A OG   1 
ATOM   1666 H  H    . SER A 1 86  ? -0.69097  -7.25403  -4.77638  1.000 32.53617 ? 86  SER A H    1 
ATOM   1667 H  HA   . SER A 1 86  ? -0.03007  -9.39466  -6.12347  1.000 29.68673 ? 86  SER A HA   1 
ATOM   1668 H  HB2  . SER A 1 86  ? 1.08260   -7.82645  -7.57638  1.000 38.99186 ? 86  SER A HB2  1 
ATOM   1669 H  HB3  . SER A 1 86  ? -0.45508  -7.49994  -7.34327  1.000 38.99186 ? 86  SER A HB3  1 
ATOM   1670 H  HG   . SER A 1 86  ? 0.71410   -5.69833  -7.02931  1.000 55.32699 ? 86  SER A HG   1 
ATOM   1671 N  N    . ASP A 1 87  ? 2.25266   -8.28085  -4.24522  1.000 26.56147 ? 87  ASP A N    1 
ATOM   1672 C  CA   . ASP A 1 87  ? 3.52768   -8.56847  -3.59731  1.000 26.06441 ? 87  ASP A CA   1 
ATOM   1673 C  C    . ASP A 1 87  ? 3.30595   -9.73367  -2.64006  1.000 28.30332 ? 87  ASP A C    1 
ATOM   1674 O  O    . ASP A 1 87  ? 2.54581   -9.61160  -1.67599  1.000 27.63731 ? 87  ASP A O    1 
ATOM   1675 C  CB   . ASP A 1 87  ? 3.92454   -7.31554  -2.81459  1.000 27.99792 ? 87  ASP A CB   1 
ATOM   1676 C  CG   . ASP A 1 87  ? 5.23795   -7.45488  -2.03189  1.000 37.49490 ? 87  ASP A CG   1 
ATOM   1677 O  OD1  . ASP A 1 87  ? 5.77711   -8.55394  -1.87101  1.000 32.42721 ? 87  ASP A OD1  1 
ATOM   1678 O  OD2  . ASP A 1 87  ? 5.75097   -6.41131  -1.56709  1.000 50.93352 ? 87  ASP A OD2  1 
ATOM   1679 H  H    . ASP A 1 87  ? 1.81109   -7.67110  -3.82950  1.000 31.87440 ? 87  ASP A H    1 
ATOM   1680 H  HA   . ASP A 1 87  ? 4.22219   -8.80982  -4.23001  1.000 31.27793 ? 87  ASP A HA   1 
ATOM   1681 H  HB2  . ASP A 1 87  ? 4.03023   -6.57998  -3.43803  1.000 33.59814 ? 87  ASP A HB2  1 
ATOM   1682 H  HB3  . ASP A 1 87  ? 3.22239   -7.11182  -2.17710  1.000 33.59814 ? 87  ASP A HB3  1 
ATOM   1683 N  N    . ILE A 1 88  ? 3.95784   -10.86608 -2.91581  1.000 24.63157 ? 88  ILE A N    1 
ATOM   1684 C  CA   . ILE A 1 88  ? 3.70773   -12.07597 -2.12729  1.000 22.52251 ? 88  ILE A CA   1 
ATOM   1685 C  C    . ILE A 1 88  ? 4.46788   -12.15052 -0.81568  1.000 23.80590 ? 88  ILE A C    1 
ATOM   1686 O  O    . ILE A 1 88  ? 4.34725   -13.15675 -0.09679  1.000 21.90227 ? 88  ILE A O    1 
ATOM   1687 C  CB   . ILE A 1 88  ? 3.97482   -13.35662 -2.94398  1.000 21.82401 ? 88  ILE A CB   1 
ATOM   1688 C  CG1  . ILE A 1 88  ? 5.47717   -13.51436 -3.29658  1.000 29.99834 ? 88  ILE A CG1  1 
ATOM   1689 C  CG2  . ILE A 1 88  ? 3.12382   -13.36268 -4.19175  1.000 27.27207 ? 88  ILE A CG2  1 
ATOM   1690 C  CD1  . ILE A 1 88  ? 5.83881   -14.93612 -3.83632  1.000 28.27562 ? 88  ILE A CD1  1 
ATOM   1691 H  H    . ILE A 1 88  ? 4.53925   -10.95846 -3.54273  1.000 29.55853 ? 88  ILE A H    1 
ATOM   1692 H  HA   . ILE A 1 88  ? 2.76594   -12.04771 -1.89678  1.000 27.02765 ? 88  ILE A HA   1 
ATOM   1693 H  HB   . ILE A 1 88  ? 3.73154   -14.11574 -2.39130  1.000 26.18946 ? 88  ILE A HB   1 
ATOM   1694 H  HG12 . ILE A 1 88  ? 5.70825   -12.86772 -3.98168  1.000 35.99865 ? 88  ILE A HG12 1 
ATOM   1695 H  HG13 . ILE A 1 88  ? 6.00514   -13.35523 -2.49857  1.000 35.99865 ? 88  ILE A HG13 1 
ATOM   1696 H  HG21 . ILE A 1 88  ? 3.29488   -14.17916 -4.68671  1.000 32.72713 ? 88  ILE A HG21 1 
ATOM   1697 H  HG22 . ILE A 1 88  ? 2.18894   -13.32024 -3.93661  1.000 32.72713 ? 88  ILE A HG22 1 
ATOM   1698 H  HG23 . ILE A 1 88  ? 3.35384   -12.59243 -4.73462  1.000 32.72713 ? 88  ILE A HG23 1 
ATOM   1699 H  HD11 . ILE A 1 88  ? 6.72144   -14.90651 -4.23755  1.000 33.93138 ? 88  ILE A HD11 1 
ATOM   1700 H  HD12 . ILE A 1 88  ? 5.83198   -15.56532 -3.09811  1.000 33.93138 ? 88  ILE A HD12 1 
ATOM   1701 H  HD13 . ILE A 1 88  ? 5.18219   -15.19824 -4.50044  1.000 33.93138 ? 88  ILE A HD13 1 
ATOM   1702 N  N    . THR A 1 89  ? 5.23846   -11.12218 -0.45623  1.000 24.48431 ? 89  THR A N    1 
ATOM   1703 C  CA   . THR A 1 89  ? 6.04735   -11.16704 0.75549   1.000 22.07284 ? 89  THR A CA   1 
ATOM   1704 C  C    . THR A 1 89  ? 5.24366   -11.62373 1.97719   1.000 21.48086 ? 89  THR A C    1 
ATOM   1705 O  O    . THR A 1 89  ? 5.65606   -12.52632 2.70398   1.000 23.34180 ? 89  THR A O    1 
ATOM   1706 C  CB   . THR A 1 89  ? 6.66095   -9.78084  0.99265   1.000 24.61172 ? 89  THR A CB   1 
ATOM   1707 O  OG1  . THR A 1 89  ? 7.48241   -9.45566  -0.13205  1.000 30.37003 ? 89  THR A OG1  1 
ATOM   1708 C  CG2  . THR A 1 89  ? 7.50918   -9.79586  2.24416   1.000 29.23242 ? 89  THR A CG2  1 
ATOM   1709 H  H    . THR A 1 89  ? 5.30918   -10.38784 -0.89821  1.000 29.38181 ? 89  THR A H    1 
ATOM   1710 H  HA   . THR A 1 89  ? 6.75924   -11.81438 0.63279   1.000 26.48805 ? 89  THR A HA   1 
ATOM   1711 H  HB   . THR A 1 89  ? 5.96563   -9.11372  1.10389   1.000 29.53471 ? 89  THR A HB   1 
ATOM   1712 H  HG1  . THR A 1 89  ? 8.27356   -9.32510  0.11820   1.000 36.44467 ? 89  THR A HG1  1 
ATOM   1713 H  HG21 . THR A 1 89  ? 8.12653   -9.04772  2.23552   1.000 35.07954 ? 89  THR A HG21 1 
ATOM   1714 H  HG22 . THR A 1 89  ? 6.94347   -9.72812  3.02920   1.000 35.07954 ? 89  THR A HG22 1 
ATOM   1715 H  HG23 . THR A 1 89  ? 8.01592   -10.62161 2.29161   1.000 35.07954 ? 89  THR A HG23 1 
ATOM   1716 N  N    . ALA A 1 90  ? 4.10356   -10.98533 2.25044   1.000 23.10927 ? 90  ALA A N    1 
ATOM   1717 C  CA   . ALA A 1 90  ? 3.35944   -11.32956 3.45923   1.000 23.43103 ? 90  ALA A CA   1 
ATOM   1718 C  C    . ALA A 1 90  ? 2.88373   -12.78224 3.43665   1.000 22.54270 ? 90  ALA A C    1 
ATOM   1719 O  O    . ALA A 1 90  ? 2.94894   -13.47771 4.45891   1.000 22.21377 ? 90  ALA A O    1 
ATOM   1720 C  CB   . ALA A 1 90  ? 2.17894   -10.36783 3.63766   1.000 25.25829 ? 90  ALA A CB   1 
ATOM   1721 H  H    . ALA A 1 90  ? 3.75081   -10.36807 1.76654   1.000 27.73176 ? 90  ALA A H    1 
ATOM   1722 H  HA   . ALA A 1 90  ? 3.94650   -11.22947 4.22489   1.000 28.11787 ? 90  ALA A HA   1 
ATOM   1723 H  HB1  . ALA A 1 90  ? 1.63405   -10.67111 4.38064   1.000 30.31059 ? 90  ALA A HB1  1 
ATOM   1724 H  HB2  . ALA A 1 90  ? 2.52084   -9.47850  3.81958   1.000 30.31059 ? 90  ALA A HB2  1 
ATOM   1725 H  HB3  . ALA A 1 90  ? 1.65242   -10.35956 2.82304   1.000 30.31059 ? 90  ALA A HB3  1 
ATOM   1726 N  N    . SER A 1 91  ? 2.40770   -13.26268 2.28173   1.000 19.75866 ? 91  SER A N    1 
ATOM   1727 C  CA   . SER A 1 91  ? 1.99302   -14.65548 2.19401   1.000 18.27035 ? 91  SER A CA   1 
ATOM   1728 C  C    . SER A 1 91  ? 3.15584   -15.59656 2.43005   1.000 20.36082 ? 91  SER A C    1 
ATOM   1729 O  O    . SER A 1 91  ? 2.99615   -16.61376 3.10358   1.000 20.36409 ? 91  SER A O    1 
ATOM   1730 C  CB   . SER A 1 91  ? 1.39552   -14.89910 0.82695   1.000 19.96849 ? 91  SER A CB   1 
ATOM   1731 O  OG   . SER A 1 91  ? 0.06730   -14.42123 0.76741   1.000 21.59950 ? 91  SER A OG   1 
ATOM   1732 H  H    . SER A 1 91  ? 2.31891   -12.81048 1.55563   1.000 23.71103 ? 91  SER A H    1 
ATOM   1733 H  HA   . SER A 1 91  ? 1.32496   -14.83560 2.87383   1.000 21.92506 ? 91  SER A HA   1 
ATOM   1734 H  HB2  . SER A 1 91  ? 1.92823   -14.43528 0.16213   1.000 23.96283 ? 91  SER A HB2  1 
ATOM   1735 H  HB3  . SER A 1 91  ? 1.39670   -15.85225 0.64696   1.000 23.96283 ? 91  SER A HB3  1 
ATOM   1736 H  HG   . SER A 1 91  ? -0.22709  -14.48773 -0.01650  1.000 25.92004 ? 91  SER A HG   1 
ATOM   1737 N  N    . VAL A 1 92  ? 4.31960   -15.30102 1.85296   1.000 20.29665 ? 92  VAL A N    1 
ATOM   1738 C  CA   . VAL A 1 92  ? 5.48871   -16.15342 2.03428   1.000 19.94624 ? 92  VAL A CA   1 
ATOM   1739 C  C    . VAL A 1 92  ? 5.93010   -16.17058 3.47903   1.000 22.60231 ? 92  VAL A C    1 
ATOM   1740 O  O    . VAL A 1 92  ? 6.22108   -17.23612 4.04205   1.000 22.32758 ? 92  VAL A O    1 
ATOM   1741 C  CB   . VAL A 1 92  ? 6.62920   -15.70808 1.09889   1.000 22.55497 ? 92  VAL A CB   1 
ATOM   1742 C  CG1  . VAL A 1 92  ? 7.93972   -16.34230 1.54577   1.000 27.57527 ? 92  VAL A CG1  1 
ATOM   1743 C  CG2  . VAL A 1 92  ? 6.27863   -16.05185 -0.31548  1.000 26.51293 ? 92  VAL A CG2  1 
ATOM   1744 H  H    . VAL A 1 92  ? 4.45742   -14.61473 1.35335   1.000 24.35662 ? 92  VAL A H    1 
ATOM   1745 H  HA   . VAL A 1 92  ? 5.23800   -17.05932 1.79472   1.000 23.93613 ? 92  VAL A HA   1 
ATOM   1746 H  HB   . VAL A 1 92  ? 6.75120   -14.74666 1.13996   1.000 27.06660 ? 92  VAL A HB   1 
ATOM   1747 H  HG11 . VAL A 1 92  ? 8.57120   -16.31422 0.81000   1.000 33.09097 ? 92  VAL A HG11 1 
ATOM   1748 H  HG12 . VAL A 1 92  ? 8.28983   -15.84483 2.30131   1.000 33.09097 ? 92  VAL A HG12 1 
ATOM   1749 H  HG13 . VAL A 1 92  ? 7.77340   -17.26238 1.80398   1.000 33.09097 ? 92  VAL A HG13 1 
ATOM   1750 H  HG21 . VAL A 1 92  ? 6.80733   -15.50180 -0.91451  1.000 31.81615 ? 92  VAL A HG21 1 
ATOM   1751 H  HG22 . VAL A 1 92  ? 6.47249   -16.98965 -0.46989  1.000 31.81615 ? 92  VAL A HG22 1 
ATOM   1752 H  HG23 . VAL A 1 92  ? 5.33424   -15.88163 -0.45707  1.000 31.81615 ? 92  VAL A HG23 1 
ATOM   1753 N  N    . ASN A 1 93  ? 5.98091   -15.00349 4.11621   1.000 20.26430 ? 93  ASN A N    1 
ATOM   1754 C  CA   . ASN A 1 93  ? 6.46353   -14.94092 5.48937   1.000 24.11150 ? 93  ASN A CA   1 
ATOM   1755 C  C    . ASN A 1 93  ? 5.53051   -15.68718 6.42355   1.000 21.77191 ? 93  ASN A C    1 
ATOM   1756 O  O    . ASN A 1 93  ? 5.97048   -16.38988 7.33614   1.000 24.27680 ? 93  ASN A O    1 
ATOM   1757 C  CB   . ASN A 1 93  ? 6.59259   -13.47872 5.93555   1.000 27.52702 ? 93  ASN A CB   1 
ATOM   1758 C  CG   . ASN A 1 93  ? 7.78314   -12.78669 5.29893   1.000 42.31208 ? 93  ASN A CG   1 
ATOM   1759 O  OD1  . ASN A 1 93  ? 8.61843   -13.43304 4.67573   1.000 32.17979 ? 93  ASN A OD1  1 
ATOM   1760 N  ND2  . ASN A 1 93  ? 7.85263   -11.46537 5.43557   1.000 51.78826 ? 93  ASN A ND2  1 
ATOM   1761 H  H    . ASN A 1 93  ? 5.74583   -14.24700 3.78144   1.000 24.31780 ? 93  ASN A H    1 
ATOM   1762 H  HA   . ASN A 1 93  ? 7.34136   -15.35139 5.53224   1.000 28.93444 ? 93  ASN A HA   1 
ATOM   1763 H  HB2  . ASN A 1 93  ? 5.79073   -12.99633 5.68019   1.000 33.03307 ? 93  ASN A HB2  1 
ATOM   1764 H  HB3  . ASN A 1 93  ? 6.70523   -13.44882 6.89853   1.000 33.03307 ? 93  ASN A HB3  1 
ATOM   1765 H  HD21 . ASN A 1 93  ? 7.23990   -11.04504 5.86857   1.000 62.14655 ? 93  ASN A HD21 1 
ATOM   1766 H  HD22 . ASN A 1 93  ? 8.51028   -11.03143 5.09092   1.000 62.14655 ? 93  ASN A HD22 1 
ATOM   1767 N  N    . CYS A 1 94  ? 4.21812   -15.58532 6.18815   1.000 19.16213 ? 94  CYS A N    1 
ATOM   1768 C  CA   . CYS A 1 94  ? 3.27606   -16.33247 7.00230   1.000 19.89591 ? 94  CYS A CA   1 
ATOM   1769 C  C    . CYS A 1 94  ? 3.36394   -17.83148 6.71546   1.000 20.95192 ? 94  CYS A C    1 
ATOM   1770 O  O    . CYS A 1 94  ? 3.34094   -18.64683 7.65391   1.000 20.57202 ? 94  CYS A O    1 
ATOM   1771 C  CB   . CYS A 1 94  ? 1.87421   -15.77822 6.75418   1.000 20.57046 ? 94  CYS A CB   1 
ATOM   1772 S  SG   . CYS A 1 94  ? 0.59985   -16.46155 7.82259   1.000 21.90732 ? 94  CYS A SG   1 
ATOM   1773 H  H    . CYS A 1 94  ? 3.86135   -15.09933 5.57486   1.000 22.99519 ? 94  CYS A H    1 
ATOM   1774 H  HA   . CYS A 1 94  ? 3.47956   -16.22142 7.94419   1.000 23.87573 ? 94  CYS A HA   1 
ATOM   1775 H  HB2  . CYS A 1 94  ? 1.89211   -14.81889 6.89653   1.000 24.68519 ? 94  CYS A HB2  1 
ATOM   1776 H  HB3  . CYS A 1 94  ? 1.62323   -15.97300 5.83768   1.000 24.68519 ? 94  CYS A HB3  1 
ATOM   1777 N  N    . ALA A 1 95  ? 3.51620   -18.21134 5.44497   1.000 19.88646 ? 95  ALA A N    1 
ATOM   1778 C  CA   . ALA A 1 95  ? 3.67363   -19.62825 5.10290   1.000 19.03516 ? 95  ALA A CA   1 
ATOM   1779 C  C    . ALA A 1 95  ? 4.88590   -20.24816 5.78418   1.000 19.37158 ? 95  ALA A C    1 
ATOM   1780 O  O    . ALA A 1 95  ? 4.84545   -21.42791 6.12682   1.000 20.52961 ? 95  ALA A O    1 
ATOM   1781 C  CB   . ALA A 1 95  ? 3.77485   -19.81273 3.60405   1.000 19.65506 ? 95  ALA A CB   1 
ATOM   1782 H  H    . ALA A 1 95  ? 3.53189   -17.67775 4.77070   1.000 23.86439 ? 95  ALA A H    1 
ATOM   1783 H  HA   . ALA A 1 95  ? 2.88047   -20.09260 5.41301   1.000 22.84283 ? 95  ALA A HA   1 
ATOM   1784 H  HB1  . ALA A 1 95  ? 3.91244   -20.75315 3.41019   1.000 23.58671 ? 95  ALA A HB1  1 
ATOM   1785 H  HB2  . ALA A 1 95  ? 2.95169   -19.50702 3.19194   1.000 23.58671 ? 95  ALA A HB2  1 
ATOM   1786 H  HB3  . ALA A 1 95  ? 4.52380   -19.29349 3.27182   1.000 23.58671 ? 95  ALA A HB3  1 
ATOM   1787 N  N    . LYS A 1 96  ? 5.98264   -19.49870 5.93947   1.000 20.21255 ? 96  LYS A N    1 
ATOM   1788 C  CA   . LYS A 1 96  ? 7.14735   -20.04852 6.62725   1.000 21.61731 ? 96  LYS A CA   1 
ATOM   1789 C  C    . LYS A 1 96  ? 6.80063   -20.39600 8.07278   1.000 21.90638 ? 96  LYS A C    1 
ATOM   1790 O  O    . LYS A 1 96  ? 7.28655   -21.39196 8.61901   1.000 23.24756 ? 96  LYS A O    1 
ATOM   1791 C  CB   . LYS A 1 96  ? 8.27129   -19.01457 6.58092   1.000 21.29189 ? 96  LYS A CB   1 
ATOM   1792 C  CG   . LYS A 1 96  ? 8.87678   -18.83116 5.22849   1.000 22.52972 ? 96  LYS A CG   1 
ATOM   1793 C  CD   . LYS A 1 96  ? 10.04597  -17.82932 5.26204   1.000 27.17291 ? 96  LYS A CD   1 
ATOM   1794 C  CE   . LYS A 1 96  ? 10.69609  -17.69937 3.88282   1.000 31.12381 ? 96  LYS A CE   1 
ATOM   1795 N  NZ   . LYS A 1 96  ? 11.69860  -16.58223 3.83507   1.000 34.92637 ? 96  LYS A NZ   1 
ATOM   1796 H  H    . LYS A 1 96  ? 6.07329   -18.68973 5.66206   1.000 24.25570 ? 96  LYS A H    1 
ATOM   1797 H  HA   . LYS A 1 96  ? 7.44651   -20.85901 6.18621   1.000 25.94142 ? 96  LYS A HA   1 
ATOM   1798 H  HB2  . LYS A 1 96  ? 7.91610   -18.15725 6.86332   1.000 25.55091 ? 96  LYS A HB2  1 
ATOM   1799 H  HB3  . LYS A 1 96  ? 8.97704   -19.29615 7.18386   1.000 25.55091 ? 96  LYS A HB3  1 
ATOM   1800 H  HG2  . LYS A 1 96  ? 9.21463   -19.68279 4.90993   1.000 27.03630 ? 96  LYS A HG2  1 
ATOM   1801 H  HG3  . LYS A 1 96  ? 8.20299   -18.49240 4.61845   1.000 27.03630 ? 96  LYS A HG3  1 
ATOM   1802 H  HD2  . LYS A 1 96  ? 9.71668   -16.95705 5.52965   1.000 32.60813 ? 96  LYS A HD2  1 
ATOM   1803 H  HD3  . LYS A 1 96  ? 10.71774  -18.13740 5.89031   1.000 32.60813 ? 96  LYS A HD3  1 
ATOM   1804 H  HE2  . LYS A 1 96  ? 11.15420  -18.52665 3.66686   1.000 37.34921 ? 96  LYS A HE2  1 
ATOM   1805 H  HE3  . LYS A 1 96  ? 10.00931  -17.51823 3.22220   1.000 37.34921 ? 96  LYS A HE3  1 
ATOM   1806 H  HZ1  . LYS A 1 96  ? 12.05219  -16.52516 3.02032   1.000 41.91229 ? 96  LYS A HZ1  1 
ATOM   1807 H  HZ2  . LYS A 1 96  ? 11.30331  -15.80983 4.03314   1.000 41.91229 ? 96  LYS A HZ2  1 
ATOM   1808 H  HZ3  . LYS A 1 96  ? 12.34992  -16.73240 4.42272   1.000 41.91229 ? 96  LYS A HZ3  1 
ATOM   1809 N  N    A LYS A 1 97  ? 5.96220   -19.57978 8.71529   0.527 20.98761 ? 97  LYS A N    1 
ATOM   1810 N  N    B LYS A 1 97  ? 5.97634   -19.57458 8.72562   0.473 20.94691 ? 97  LYS A N    1 
ATOM   1811 C  CA   A LYS A 1 97  ? 5.53169   -19.87345 10.07993  0.527 20.53929 ? 97  LYS A CA   1 
ATOM   1812 C  CA   B LYS A 1 97  ? 5.55700   -19.90313 10.08544  0.473 20.56966 ? 97  LYS A CA   1 
ATOM   1813 C  C    A LYS A 1 97  ? 4.64375   -21.11435 10.12822  0.527 22.42044 ? 97  LYS A C    1 
ATOM   1814 C  C    B LYS A 1 97  ? 4.67799   -21.14953 10.10258  0.473 22.45606 ? 97  LYS A C    1 
ATOM   1815 O  O    A LYS A 1 97  ? 4.77369   -21.95380 11.03101  0.527 25.33424 ? 97  LYS A O    1 
ATOM   1816 O  O    B LYS A 1 97  ? 4.86570   -22.04113 10.94142  0.473 24.71736 ? 97  LYS A O    1 
ATOM   1817 C  CB   A LYS A 1 97  ? 4.80091   -18.65325 10.64955  0.527 23.63544 ? 97  LYS A CB   1 
ATOM   1818 C  CB   B LYS A 1 97  ? 4.84133   -18.70960 10.72498  0.473 23.72876 ? 97  LYS A CB   1 
ATOM   1819 C  CG   A LYS A 1 97  ? 5.71715   -17.45624 10.92070  0.527 26.83854 ? 97  LYS A CG   1 
ATOM   1820 C  CG   B LYS A 1 97  ? 4.50433   -18.92132 12.20158  0.473 26.47662 ? 97  LYS A CG   1 
ATOM   1821 C  CD   A LYS A 1 97  ? 4.97393   -16.26384 11.52244  0.527 39.24965 ? 97  LYS A CD   1 
ATOM   1822 C  CD   B LYS A 1 97  ? 3.94278   -17.66385 12.88806  0.473 33.64809 ? 97  LYS A CD   1 
ATOM   1823 C  CE   A LYS A 1 97  ? 5.69983   -14.94239 11.22819  0.527 37.18788 ? 97  LYS A CE   1 
ATOM   1824 C  CE   B LYS A 1 97  ? 4.94753   -16.51835 13.05770  0.473 40.84868 ? 97  LYS A CE   1 
ATOM   1825 N  NZ   A LYS A 1 97  ? 4.80673   -13.74489 11.30541  0.527 41.75048 ? 97  LYS A NZ   1 
ATOM   1826 N  NZ   B LYS A 1 97  ? 6.35850   -16.81079 12.67223  0.473 56.83036 ? 97  LYS A NZ   1 
ATOM   1827 H  H    A LYS A 1 97  ? 5.63188   -18.85714 8.38621   0.527 25.18578 ? 97  LYS A H    1 
ATOM   1828 H  H    B LYS A 1 97  ? 5.65479   -18.84128 8.41182   0.473 25.13693 ? 97  LYS A H    1 
ATOM   1829 H  HA   A LYS A 1 97  ? 6.30844   -20.05173 10.63289  0.527 24.64779 ? 97  LYS A HA   1 
ATOM   1830 H  HA   B LYS A 1 97  ? 6.34375   -20.08836 10.62173  0.473 24.68423 ? 97  LYS A HA   1 
ATOM   1831 H  HB2  A LYS A 1 97  ? 4.12440   -18.37047 10.01451  0.527 28.36316 ? 97  LYS A HB2  1 
ATOM   1832 H  HB2  B LYS A 1 97  ? 5.41417   -17.92954 10.65958  0.473 28.47515 ? 97  LYS A HB2  1 
ATOM   1833 H  HB3  A LYS A 1 97  ? 4.38410   -18.90326 11.48900  0.527 28.36316 ? 97  LYS A HB3  1 
ATOM   1834 H  HB3  B LYS A 1 97  ? 4.01044   -18.55178 10.25000  0.473 28.47515 ? 97  LYS A HB3  1 
ATOM   1835 H  HG2  A LYS A 1 97  ? 6.40956   -17.72327 11.54534  0.527 32.20689 ? 97  LYS A HG2  1 
ATOM   1836 H  HG2  B LYS A 1 97  ? 3.83710   -19.62166 12.27390  0.473 31.77258 ? 97  LYS A HG2  1 
ATOM   1837 H  HG3  A LYS A 1 97  ? 6.11711   -17.16864 10.08511  0.527 32.20689 ? 97  LYS A HG3  1 
ATOM   1838 H  HG3  B LYS A 1 97  ? 5.31093   -19.18156 12.67337  0.473 31.77258 ? 97  LYS A HG3  1 
ATOM   1839 H  HD2  A LYS A 1 97  ? 4.08351   -16.21424 11.14088  0.527 47.10022 ? 97  LYS A HD2  1 
ATOM   1840 H  HD2  B LYS A 1 97  ? 3.20454   -17.32635 12.35702  0.473 40.37835 ? 97  LYS A HD2  1 
ATOM   1841 H  HD3  A LYS A 1 97  ? 4.91696   -16.37286 12.48461  0.527 47.10022 ? 97  LYS A HD3  1 
ATOM   1842 H  HD3  B LYS A 1 97  ? 3.63004   -17.90926 13.77285  0.473 40.37835 ? 97  LYS A HD3  1 
ATOM   1843 H  HE2  A LYS A 1 97  ? 6.41188   -14.82427 11.87621  0.527 44.62609 ? 97  LYS A HE2  1 
ATOM   1844 H  HE2  B LYS A 1 97  ? 4.65215   -15.77382 12.51058  0.473 49.01906 ? 97  LYS A HE2  1 
ATOM   1845 H  HE3  A LYS A 1 97  ? 6.06955   -14.98003 10.33221  0.527 44.62609 ? 97  LYS A HE3  1 
ATOM   1846 H  HE3  B LYS A 1 97  ? 4.95627   -16.26007 13.99264  0.473 49.01906 ? 97  LYS A HE3  1 
ATOM   1847 H  HZ1  A LYS A 1 97  ? 5.25988   -13.01228 11.08172  0.527 50.10121 ? 97  LYS A HZ1  1 
ATOM   1848 H  HZ1  B LYS A 1 97  ? 6.46985   -16.67591 11.79958  0.473 68.19708 ? 97  LYS A HZ1  1 
ATOM   1849 H  HZ2  A LYS A 1 97  ? 4.11972   -13.84108 10.74786  0.527 50.10121 ? 97  LYS A HZ2  1 
ATOM   1850 H  HZ2  B LYS A 1 97  ? 6.91308   -16.27781 13.11996  0.473 68.19708 ? 97  LYS A HZ2  1 
ATOM   1851 H  HZ3  A LYS A 1 97  ? 4.49538   -13.65027 12.13378  0.527 50.10121 ? 97  LYS A HZ3  1 
ATOM   1852 H  HZ3  B LYS A 1 97  ? 6.55637   -17.65770 12.86115  0.473 68.19708 ? 97  LYS A HZ3  1 
ATOM   1853 N  N    . ILE A 1 98  ? 3.73768   -21.25158 9.16188   1.000 19.07588 ? 98  ILE A N    1 
ATOM   1854 C  CA   . ILE A 1 98  ? 2.83764   -22.40265 9.11500   1.000 19.58783 ? 98  ILE A CA   1 
ATOM   1855 C  C    . ILE A 1 98  ? 3.61167   -23.70658 8.91666   1.000 19.62005 ? 98  ILE A C    1 
ATOM   1856 O  O    . ILE A 1 98  ? 3.37332   -24.69095 9.62845   1.000 21.13094 ? 98  ILE A O    1 
ATOM   1857 C  CB   . ILE A 1 98  ? 1.79237   -22.19295 8.00289   1.000 18.44519 ? 98  ILE A CB   1 
ATOM   1858 C  CG1  . ILE A 1 98  ? 0.93821   -20.94803 8.26889   1.000 19.94960 ? 98  ILE A CG1  1 
ATOM   1859 C  CG2  . ILE A 1 98  ? 0.93379   -23.43870 7.82724   1.000 19.73178 ? 98  ILE A CG2  1 
ATOM   1860 C  CD1  . ILE A 1 98  ? 0.04864   -20.53853 7.10181   1.000 22.95624 ? 98  ILE A CD1  1 
ATOM   1861 H  H    . ILE A 1 98  ? 3.62438   -20.69010 8.52040   1.000 22.89170 ? 98  ILE A H    1 
ATOM   1862 H  HA   . ILE A 1 98  ? 2.38203   -22.47104 9.96860   1.000 23.50603 ? 98  ILE A HA   1 
ATOM   1863 H  HB   . ILE A 1 98  ? 2.26767   -22.04055 7.17117   1.000 22.13486 ? 98  ILE A HB   1 
ATOM   1864 H  HG12 . ILE A 1 98  ? 0.36266   -21.12376 9.02965   1.000 23.94016 ? 98  ILE A HG12 1 
ATOM   1865 H  HG13 . ILE A 1 98  ? 1.52818   -20.20327 8.46425   1.000 23.94016 ? 98  ILE A HG13 1 
ATOM   1866 H  HG21 . ILE A 1 98  ? 0.28158   -23.27668 7.12776   1.000 23.67878 ? 98  ILE A HG21 1 
ATOM   1867 H  HG22 . ILE A 1 98  ? 1.50450   -24.18348 7.58129   1.000 23.67878 ? 98  ILE A HG22 1 
ATOM   1868 H  HG23 . ILE A 1 98  ? 0.48124   -23.63082 8.66342   1.000 23.67878 ? 98  ILE A HG23 1 
ATOM   1869 H  HD11 . ILE A 1 98  ? 0.59496   -20.44579 6.30568   1.000 27.54813 ? 98  ILE A HD11 1 
ATOM   1870 H  HD12 . ILE A 1 98  ? -0.62492  -21.22258 6.96294   1.000 27.54813 ? 98  ILE A HD12 1 
ATOM   1871 H  HD13 . ILE A 1 98  ? -0.37732  -19.69255 7.31107   1.000 27.54813 ? 98  ILE A HD13 1 
ATOM   1872 N  N    . VAL A 1 99  ? 4.50414   -23.74485 7.91935   1.000 19.48518 ? 99  VAL A N    1 
ATOM   1873 C  CA   . VAL A 1 99  ? 5.20735   -24.96707 7.56477   1.000 19.59183 ? 99  VAL A CA   1 
ATOM   1874 C  C    . VAL A 1 99  ? 6.15885   -25.38309 8.65460   1.000 24.80344 ? 99  VAL A C    1 
ATOM   1875 O  O    . VAL A 1 99  ? 6.53196   -26.55477 8.70933   1.000 25.02501 ? 99  VAL A O    1 
ATOM   1876 C  CB   . VAL A 1 99  ? 5.90019   -24.78929 6.20180   1.000 19.58403 ? 99  VAL A CB   1 
ATOM   1877 C  CG1  . VAL A 1 99  ? 7.19165   -23.97116 6.30427   1.000 20.91751 ? 99  VAL A CG1  1 
ATOM   1878 C  CG2  . VAL A 1 99  ? 6.17464   -26.12882 5.54469   1.000 23.71982 ? 99  VAL A CG2  1 
ATOM   1879 H  H    . VAL A 1 99  ? 4.71746   -23.06845 7.43296   1.000 23.38286 ? 99  VAL A H    1 
ATOM   1880 H  HA   . VAL A 1 99  ? 4.57297   -25.69409 7.46523   1.000 23.51083 ? 99  VAL A HA   1 
ATOM   1881 H  HB   . VAL A 1 99  ? 5.28823   -24.29023 5.63848   1.000 23.50148 ? 99  VAL A HB   1 
ATOM   1882 H  HG11 . VAL A 1 99  ? 7.46600   -23.70127 5.41389   1.000 25.10166 ? 99  VAL A HG11 1 
ATOM   1883 H  HG12 . VAL A 1 99  ? 7.02639   -23.18735 6.85129   1.000 25.10166 ? 99  VAL A HG12 1 
ATOM   1884 H  HG13 . VAL A 1 99  ? 7.88110   -24.51900 6.71100   1.000 25.10166 ? 99  VAL A HG13 1 
ATOM   1885 H  HG21 . VAL A 1 99  ? 6.51444   -25.97740 4.64886   1.000 28.46443 ? 99  VAL A HG21 1 
ATOM   1886 H  HG22 . VAL A 1 99  ? 6.83227   -26.60991 6.07098   1.000 28.46443 ? 99  VAL A HG22 1 
ATOM   1887 H  HG23 . VAL A 1 99  ? 5.34862   -26.63568 5.50386   1.000 28.46443 ? 99  VAL A HG23 1 
ATOM   1888 N  N    . SER A 1 100 ? 6.49852   -24.47199 9.56134   1.000 24.13228 ? 100 SER A N    1 
ATOM   1889 C  CA   . SER A 1 100 ? 7.39704   -24.76153 10.67185  1.000 26.29135 ? 100 SER A CA   1 
ATOM   1890 C  C    . SER A 1 100 ? 6.68595   -25.19643 11.94591  1.000 27.55558 ? 100 SER A C    1 
ATOM   1891 O  O    . SER A 1 100 ? 7.36598   -25.43670 12.95498  1.000 34.51592 ? 100 SER A O    1 
ATOM   1892 C  CB   . SER A 1 100 ? 8.20012   -23.50848 11.01331  1.000 28.34900 ? 100 SER A CB   1 
ATOM   1893 O  OG   . SER A 1 100 ? 9.01393   -23.08593 9.94978   1.000 30.39836 ? 100 SER A OG   1 
ATOM   1894 H  H    . SER A 1 100 ? 6.21448   -23.66028 9.55389   1.000 28.95937 ? 100 SER A H    1 
ATOM   1895 H  HA   . SER A 1 100 ? 7.98699   -25.47775 10.38918  1.000 31.55026 ? 100 SER A HA   1 
ATOM   1896 H  HB2  . SER A 1 100 ? 7.58099   -22.79436 11.23151  1.000 34.01944 ? 100 SER A HB2  1 
ATOM   1897 H  HB3  . SER A 1 100 ? 8.76559   -23.70228 11.77724  1.000 34.01944 ? 100 SER A HB3  1 
ATOM   1898 H  HG   . SER A 1 100 ? 8.54452   -22.94327 9.26794   1.000 36.47867 ? 100 SER A HG   1 
ATOM   1899 N  N    A ASP A 1 101 ? 5.36887   -25.30790 11.94589  0.646 26.13979 ? 101 ASP A N    1 
ATOM   1900 N  N    B ASP A 1 101 ? 5.35408   -25.31363 11.93140  0.354 26.21636 ? 101 ASP A N    1 
ATOM   1901 C  CA   A ASP A 1 101 ? 4.63156   -25.52360 13.17990  0.646 32.24610 ? 101 ASP A CA   1 
ATOM   1902 C  CA   B ASP A 1 101 ? 4.56363   -25.53530 13.13846  0.354 32.25557 ? 101 ASP A CA   1 
ATOM   1903 C  C    A ASP A 1 101 ? 4.50296   -26.98957 13.56078  0.646 35.96421 ? 101 ASP A C    1 
ATOM   1904 C  C    B ASP A 1 101 ? 4.52133   -26.99241 13.57152  0.354 35.83590 ? 101 ASP A C    1 
ATOM   1905 O  O    A ASP A 1 101 ? 3.86356   -27.29101 14.57396  0.646 38.01631 ? 101 ASP A O    1 
ATOM   1906 O  O    B ASP A 1 101 ? 3.96981   -27.29276 14.63702  0.354 37.78336 ? 101 ASP A O    1 
ATOM   1907 C  CB   A ASP A 1 101 ? 3.26052   -24.86162 13.08817  0.646 29.92219 ? 101 ASP A CB   1 
ATOM   1908 C  CB   B ASP A 1 101 ? 3.13080   -25.04428 12.90859  0.354 30.68294 ? 101 ASP A CB   1 
ATOM   1909 C  CG   A ASP A 1 101 ? 2.24647   -25.68155 12.31485  0.646 30.15185 ? 101 ASP A CG   1 
ATOM   1910 C  CG   B ASP A 1 101 ? 2.53205   -24.36685 14.13405  0.354 44.32198 ? 101 ASP A CG   1 
ATOM   1911 O  OD1  A ASP A 1 101 ? 2.56889   -26.77713 11.78325  0.646 29.02120 ? 101 ASP A OD1  1 
ATOM   1912 O  OD1  B ASP A 1 101 ? 3.29993   -23.87603 14.98904  0.354 54.47561 ? 101 ASP A OD1  1 
ATOM   1913 O  OD2  A ASP A 1 101 ? 1.10681   -25.18979 12.20104  0.646 34.02668 ? 101 ASP A OD2  1 
ATOM   1914 O  OD2  B ASP A 1 101 ? 1.28810   -24.31215 14.23216  0.354 49.75306 ? 101 ASP A OD2  1 
ATOM   1915 H  H    A ASP A 1 101 ? 4.87702   -25.26208 11.24192  0.646 31.36839 ? 101 ASP A H    1 
ATOM   1916 H  H    B ASP A 1 101 ? 4.87712   -25.26690 11.21731  0.354 31.46027 ? 101 ASP A H    1 
ATOM   1917 H  HA   A ASP A 1 101 ? 5.10881   -25.09483 13.90742  0.646 38.69596 ? 101 ASP A HA   1 
ATOM   1918 H  HA   B ASP A 1 101 ? 4.95845   -25.02389 13.86198  0.354 38.70732 ? 101 ASP A HA   1 
ATOM   1919 H  HB2  A ASP A 1 101 ? 2.91493   -24.73051 13.98498  0.646 35.90727 ? 101 ASP A HB2  1 
ATOM   1920 H  HB2  B ASP A 1 101 ? 3.13020   -24.40220 12.18153  0.354 36.82017 ? 101 ASP A HB2  1 
ATOM   1921 H  HB3  A ASP A 1 101 ? 3.35459   -24.00624 12.64053  0.646 35.90727 ? 101 ASP A HB3  1 
ATOM   1922 H  HB3  B ASP A 1 101 ? 2.57001   -25.80261 12.68197  0.354 36.82017 ? 101 ASP A HB3  1 
ATOM   1923 N  N    . GLY A 1 102 ? 5.08320   -27.90878 12.78573  1.000 29.71574 ? 102 GLY A N    1 
ATOM   1924 C  CA   . GLY A 1 102 ? 5.12028   -29.31790 13.13457  1.000 30.67891 ? 102 GLY A CA   1 
ATOM   1925 C  C    . GLY A 1 102 ? 4.53504   -30.25524 12.09546  1.000 30.04453 ? 102 GLY A C    1 
ATOM   1926 O  O    . GLY A 1 102 ? 4.94571   -31.41992 12.02921  1.000 28.79882 ? 102 GLY A O    1 
ATOM   1927 H  H    . GLY A 1 102 ? 5.46924   -27.73266 12.03769  1.000 35.65953 ? 102 GLY A H    1 
ATOM   1928 H  HA2  . GLY A 1 102 ? 6.04389   -29.57745 13.27771  1.000 36.81533 ? 102 GLY A HA2  1 
ATOM   1929 H  HA3  . GLY A 1 102 ? 4.62485   -29.44624 13.95857  1.000 36.81533 ? 102 GLY A HA3  1 
ATOM   1930 N  N    A ASN A 1 103 ? 3.59760   -29.77611 11.28503  0.687 25.80584 ? 103 ASN A N    1 
ATOM   1931 N  N    B ASN A 1 103 ? 3.57118   -29.78636 11.29922  0.313 25.87981 ? 103 ASN A N    1 
ATOM   1932 C  CA   A ASN A 1 103 ? 2.91803   -30.62327 10.31633  0.687 25.20114 ? 103 ASN A CA   1 
ATOM   1933 C  CA   B ASN A 1 103 ? 2.90047   -30.63337 10.31691  0.313 25.28856 ? 103 ASN A CA   1 
ATOM   1934 C  C    A ASN A 1 103 ? 3.40328   -30.42117 8.89166   0.687 20.93000 ? 103 ASN A C    1 
ATOM   1935 C  C    B ASN A 1 103 ? 3.42124   -30.44890 8.89552   0.313 21.16915 ? 103 ASN A C    1 
ATOM   1936 O  O    A ASN A 1 103 ? 2.88592   -31.07268 7.97758   0.687 22.70531 ? 103 ASN A O    1 
ATOM   1937 O  O    B ASN A 1 103 ? 2.91632   -31.10390 7.97747   0.313 22.63226 ? 103 ASN A O    1 
ATOM   1938 C  CB   A ASN A 1 103 ? 1.42297   -30.41171 10.43274  0.687 29.97251 ? 103 ASN A CB   1 
ATOM   1939 C  CB   B ASN A 1 103 ? 1.38989   -30.39527 10.35156  0.313 29.96470 ? 103 ASN A CB   1 
ATOM   1940 C  CG   A ASN A 1 103 ? 0.92478   -30.78082 11.79851  0.687 34.64741 ? 103 ASN A CG   1 
ATOM   1941 C  CG   B ASN A 1 103 ? 0.61754   -31.64070 10.74661  0.313 39.27003 ? 103 ASN A CG   1 
ATOM   1942 O  OD1  A ASN A 1 103 ? 1.17138   -31.89341 12.25895  0.687 39.69955 ? 103 ASN A OD1  1 
ATOM   1943 O  OD1  B ASN A 1 103 ? 0.05543   -31.71693 11.83871  0.313 41.36519 ? 103 ASN A OD1  1 
ATOM   1944 N  ND2  A ASN A 1 103 ? 0.25542   -29.85422 12.46713  0.687 44.55406 ? 103 ASN A ND2  1 
ATOM   1945 N  ND2  B ASN A 1 103 ? 0.59374   -32.62731 9.86010   0.313 36.74543 ? 103 ASN A ND2  1 
ATOM   1946 H  H    A ASN A 1 103 ? 3.33690   -28.95660 11.27868  0.687 30.96765 ? 103 ASN A H    1 
ATOM   1947 H  H    B ASN A 1 103 ? 3.28796   -28.97442 11.31131  0.313 31.05641 ? 103 ASN A H    1 
ATOM   1948 H  HA   A ASN A 1 103 ? 3.10036   -31.55304 10.52413  0.687 30.24201 ? 103 ASN A HA   1 
ATOM   1949 H  HA   B ASN A 1 103 ? 3.05945   -31.55833 10.56199  0.313 30.34691 ? 103 ASN A HA   1 
ATOM   1950 H  HB2  A ASN A 1 103 ? 1.21707   -29.47718 10.27411  0.687 35.96765 ? 103 ASN A HB2  1 
ATOM   1951 H  HB2  B ASN A 1 103 ? 1.19273   -29.70021 10.99880  0.313 35.95828 ? 103 ASN A HB2  1 
ATOM   1952 H  HB3  A ASN A 1 103 ? 0.96782   -30.96705 9.78055   0.687 35.96765 ? 103 ASN A HB3  1 
ATOM   1953 H  HB3  B ASN A 1 103 ? 1.09116   -30.12213 9.47005   0.313 35.95828 ? 103 ASN A HB3  1 
ATOM   1954 H  HD21 A ASN A 1 103 ? 0.12335   -29.08088 12.11484  0.687 53.46551 ? 103 ASN A HD21 1 
ATOM   1955 H  HD21 B ASN A 1 103 ? 0.16937   -33.35411 10.03690  0.313 44.09516 ? 103 ASN A HD21 1 
ATOM   1956 H  HD22 A ASN A 1 103 ? -0.04721  -30.02581 13.25362  0.687 53.46551 ? 103 ASN A HD22 1 
ATOM   1957 H  HD22 B ASN A 1 103 ? 1.00269   -32.54010 9.10860   0.313 44.09516 ? 103 ASN A HD22 1 
ATOM   1958 N  N    . GLY A 1 104 ? 4.43734   -29.61617 8.70206   1.000 20.34772 ? 104 GLY A N    1 
ATOM   1959 C  CA   . GLY A 1 104 ? 4.99265   -29.41409 7.38619   1.000 20.40206 ? 104 GLY A CA   1 
ATOM   1960 C  C    . GLY A 1 104 ? 3.93640   -28.90886 6.43327   1.000 18.69122 ? 104 GLY A C    1 
ATOM   1961 O  O    . GLY A 1 104 ? 3.03091   -28.13694 6.79740   1.000 20.66061 ? 104 GLY A O    1 
ATOM   1962 H  H    . GLY A 1 104 ? 4.83256   -29.17634 9.32652   1.000 24.41790 ? 104 GLY A H    1 
ATOM   1963 H  HA2  . GLY A 1 104 ? 5.71110   -28.76385 7.42979   1.000 24.48312 ? 104 GLY A HA2  1 
ATOM   1964 H  HA3  . GLY A 1 104 ? 5.34496   -30.25170 7.04679   1.000 24.48312 ? 104 GLY A HA3  1 
ATOM   1965 N  N    . MET A 1 105 ? 4.03926   -29.33701 5.20036   1.000 17.26332 ? 105 MET A N    1 
ATOM   1966 C  CA   . MET A 1 105 ? 3.09050   -28.85101 4.17651   1.000 16.36620 ? 105 MET A CA   1 
ATOM   1967 C  C    . MET A 1 105 ? 1.75865   -29.57347 4.23521   1.000 17.62945 ? 105 MET A C    1 
ATOM   1968 O  O    . MET A 1 105 ? 0.85165   -29.20850 3.47084   1.000 17.32626 ? 105 MET A O    1 
ATOM   1969 C  CB   . MET A 1 105 ? 3.68254   -28.95698 2.77886   1.000 16.73340 ? 105 MET A CB   1 
ATOM   1970 C  CG   . MET A 1 105 ? 4.86260   -28.04005 2.51215   1.000 19.04118 ? 105 MET A CG   1 
ATOM   1971 S  SD   . MET A 1 105 ? 5.20047   -27.56159 0.81371   1.000 20.62285 ? 105 MET A SD   1 
ATOM   1972 C  CE   . MET A 1 105 ? 3.64107   -26.66591 0.33229   1.000 20.88991 ? 105 MET A CE   1 
ATOM   1973 H  H    . MET A 1 105 ? 4.62915   -29.89575 4.91851   1.000 20.71663 ? 105 MET A H    1 
ATOM   1974 H  HA   . MET A 1 105 ? 2.94107   -27.90550 4.33330   1.000 19.64008 ? 105 MET A HA   1 
ATOM   1975 H  HB2  . MET A 1 105 ? 3.98525   -29.86828 2.64177   1.000 20.08072 ? 105 MET A HB2  1 
ATOM   1976 H  HB3  . MET A 1 105 ? 2.99136   -28.73659 2.13496   1.000 20.08072 ? 105 MET A HB3  1 
ATOM   1977 H  HG2  . MET A 1 105 ? 4.71517   -27.21859 3.00648   1.000 22.85005 ? 105 MET A HG2  1 
ATOM   1978 H  HG3  . MET A 1 105 ? 5.66080   -28.48461 2.83795   1.000 22.85005 ? 105 MET A HG3  1 
ATOM   1979 H  HE1  . MET A 1 105 ? 3.72528   -26.35462 -0.58254  1.000 25.06854 ? 105 MET A HE1  1 
ATOM   1980 H  HE2  . MET A 1 105 ? 2.89071   -27.27613 0.40631   1.000 25.06854 ? 105 MET A HE2  1 
ATOM   1981 H  HE3  . MET A 1 105 ? 3.51364   -25.91114 0.92810   1.000 25.06854 ? 105 MET A HE3  1 
ATOM   1982 N  N    . ASN A 1 106 ? 1.58836   -30.57354 5.11006   1.000 19.30244 ? 106 ASN A N    1 
ATOM   1983 C  CA   . ASN A 1 106 ? 0.27377   -31.19816 5.29502   1.000 18.67625 ? 106 ASN A CA   1 
ATOM   1984 C  C    . ASN A 1 106 ? -0.78194  -30.21306 5.77556   1.000 19.26859 ? 106 ASN A C    1 
ATOM   1985 O  O    . ASN A 1 106 ? -1.96933  -30.53509 5.64385   1.000 22.18504 ? 106 ASN A O    1 
ATOM   1986 C  CB   . ASN A 1 106 ? 0.42764   -32.36438 6.26329   1.000 20.47147 ? 106 ASN A CB   1 
ATOM   1987 C  CG   . ASN A 1 106 ? 1.26206   -33.49663 5.69589   1.000 19.35009 ? 106 ASN A CG   1 
ATOM   1988 O  OD1  . ASN A 1 106 ? 0.91351   -34.13257 4.69910   1.000 21.26840 ? 106 ASN A OD1  1 
ATOM   1989 N  ND2  . ASN A 1 106 ? 2.40659   -33.70081 6.28192   1.000 23.39605 ? 106 ASN A ND2  1 
ATOM   1990 H  H    . ASN A 1 106 ? 2.21108   -30.90423 5.60247   1.000 23.16357 ? 106 ASN A H    1 
ATOM   1991 H  HA   . ASN A 1 106 ? -0.05144  -31.55067 4.45189   1.000 22.41214 ? 106 ASN A HA   1 
ATOM   1992 H  HB2  . ASN A 1 106 ? 0.86164   -32.04852 7.07123   1.000 24.56641 ? 106 ASN A HB2  1 
ATOM   1993 H  HB3  . ASN A 1 106 ? -0.45094  -32.71692 6.47476   1.000 24.56641 ? 106 ASN A HB3  1 
ATOM   1994 H  HD21 . ASN A 1 106 ? 2.92510   -34.32887 6.00572   1.000 28.07590 ? 106 ASN A HD21 1 
ATOM   1995 H  HD22 . ASN A 1 106 ? 2.64409   -33.20762 6.94521   1.000 28.07590 ? 106 ASN A HD22 1 
ATOM   1996 N  N    . ALA A 1 107 ? -0.38903  -29.02972 6.23439   1.000 18.14646 ? 107 ALA A N    1 
ATOM   1997 C  CA   . ALA A 1 107 ? -1.35897  -27.99843 6.58434   1.000 21.12003 ? 107 ALA A CA   1 
ATOM   1998 C  C    . ALA A 1 107 ? -2.18486  -27.56222 5.37141   1.000 20.74931 ? 107 ALA A C    1 
ATOM   1999 O  O    . ALA A 1 107 ? -3.30951  -27.08426 5.54788   1.000 23.17402 ? 107 ALA A O    1 
ATOM   2000 C  CB   . ALA A 1 107 ? -0.64101  -26.77661 7.14925   1.000 28.06978 ? 107 ALA A CB   1 
ATOM   2001 H  H    . ALA A 1 107 ? 0.43085   -28.79847 6.35232   1.000 21.77639 ? 107 ALA A H    1 
ATOM   2002 H  HA   . ALA A 1 107 ? -1.95457  -28.35248 7.26317   1.000 25.34468 ? 107 ALA A HA   1 
ATOM   2003 H  HB1  . ALA A 1 107 ? -1.29333  -26.08094 7.32650   1.000 33.68438 ? 107 ALA A HB1  1 
ATOM   2004 H  HB2  . ALA A 1 107 ? -0.19208  -27.02649 7.97200   1.000 33.68438 ? 107 ALA A HB2  1 
ATOM   2005 H  HB3  . ALA A 1 107 ? 0.00822   -26.46364 6.50007   1.000 33.68438 ? 107 ALA A HB3  1 
ATOM   2006 N  N    . TRP A 1 108 ? -1.68392  -27.73988 4.14769   1.000 17.32460 ? 108 TRP A N    1 
ATOM   2007 C  CA   . TRP A 1 108 ? -2.37748  -27.37141 2.91409   1.000 16.63845 ? 108 TRP A CA   1 
ATOM   2008 C  C    . TRP A 1 108 ? -3.01517  -28.61954 2.34646   1.000 19.97760 ? 108 TRP A C    1 
ATOM   2009 O  O    . TRP A 1 108 ? -2.32369  -29.51491 1.85926   1.000 18.52606 ? 108 TRP A O    1 
ATOM   2010 C  CB   . TRP A 1 108 ? -1.42003  -26.74072 1.92189   1.000 17.67681 ? 108 TRP A CB   1 
ATOM   2011 C  CG   . TRP A 1 108 ? -1.04172  -25.35366 2.28301   1.000 16.91665 ? 108 TRP A CG   1 
ATOM   2012 C  CD1  . TRP A 1 108 ? -1.76187  -24.22263 2.00697   1.000 19.27552 ? 108 TRP A CD1  1 
ATOM   2013 C  CD2  . TRP A 1 108 ? 0.12738   -24.92433 2.97230   1.000 16.63713 ? 108 TRP A CD2  1 
ATOM   2014 N  NE1  . TRP A 1 108 ? -1.12380  -23.13787 2.49712   1.000 18.68427 ? 108 TRP A NE1  1 
ATOM   2015 C  CE2  . TRP A 1 108 ? 0.04679   -23.52191 3.09767   1.000 19.08531 ? 108 TRP A CE2  1 
ATOM   2016 C  CE3  . TRP A 1 108 ? 1.23248   -25.58011 3.49819   1.000 19.74454 ? 108 TRP A CE3  1 
ATOM   2017 C  CZ2  . TRP A 1 108 ? 1.02108   -22.77380 3.72001   1.000 19.18271 ? 108 TRP A CZ2  1 
ATOM   2018 C  CZ3  . TRP A 1 108 ? 2.18948   -24.83071 4.14437   1.000 20.86781 ? 108 TRP A CZ3  1 
ATOM   2019 C  CH2  . TRP A 1 108 ? 2.09984   -23.43487 4.22286   1.000 21.44196 ? 108 TRP A CH2  1 
ATOM   2020 H  H    . TRP A 1 108 ? -0.91082  -28.08694 4.00118   1.000 20.79016 ? 108 TRP A H    1 
ATOM   2021 H  HA   . TRP A 1 108 ? -3.07457  -26.72587 3.10968   1.000 19.96678 ? 108 TRP A HA   1 
ATOM   2022 H  HB2  . TRP A 1 108 ? -0.60931  -27.27205 1.88541   1.000 21.21282 ? 108 TRP A HB2  1 
ATOM   2023 H  HB3  . TRP A 1 108 ? -1.84146  -26.71811 1.04852   1.000 21.21282 ? 108 TRP A HB3  1 
ATOM   2024 H  HD1  . TRP A 1 108 ? -2.57126  -24.20397 1.54933   1.000 23.13126 ? 108 TRP A HD1  1 
ATOM   2025 H  HE1  . TRP A 1 108 ? -1.40893  -22.32846 2.44089   1.000 22.42177 ? 108 TRP A HE1  1 
ATOM   2026 H  HE3  . TRP A 1 108 ? 1.32379   -26.50196 3.41601   1.000 23.69408 ? 108 TRP A HE3  1 
ATOM   2027 H  HZ2  . TRP A 1 108 ? 0.94490   -21.84989 3.79418   1.000 23.01989 ? 108 TRP A HZ2  1 
ATOM   2028 H  HZ3  . TRP A 1 108 ? 2.91328   -25.26163 4.53847   1.000 25.04201 ? 108 TRP A HZ3  1 
ATOM   2029 H  HH2  . TRP A 1 108 ? 2.78677   -22.95311 4.62403   1.000 25.73099 ? 108 TRP A HH2  1 
ATOM   2030 N  N    A VAL A 1 109 ? -4.34514  -28.67219 2.41805   0.502 21.88867 ? 109 VAL A N    1 
ATOM   2031 N  N    B VAL A 1 109 ? -4.34037  -28.69220 2.40940   0.498 21.88754 ? 109 VAL A N    1 
ATOM   2032 C  CA   A VAL A 1 109 ? -5.08455  -29.85649 1.99716   0.502 23.23985 ? 109 VAL A CA   1 
ATOM   2033 C  CA   B VAL A 1 109 ? -4.99105  -29.93432 2.01976   0.498 22.42200 ? 109 VAL A CA   1 
ATOM   2034 C  C    A VAL A 1 109 ? -4.78849  -30.19489 0.54991   0.502 18.82478 ? 109 VAL A C    1 
ATOM   2035 C  C    B VAL A 1 109 ? -4.79926  -30.21597 0.53283   0.498 18.82935 ? 109 VAL A C    1 
ATOM   2036 O  O    A VAL A 1 109 ? -4.56385  -31.36546 0.21070   0.502 20.63930 ? 109 VAL A O    1 
ATOM   2037 O  O    B VAL A 1 109 ? -4.63492  -31.37816 0.14471   0.498 20.90338 ? 109 VAL A O    1 
ATOM   2038 C  CB   A VAL A 1 109 ? -6.58905  -29.62763 2.23688   0.502 20.48151 ? 109 VAL A CB   1 
ATOM   2039 C  CB   B VAL A 1 109 ? -6.47235  -29.90482 2.45020   0.498 26.17194 ? 109 VAL A CB   1 
ATOM   2040 C  CG1  A VAL A 1 109 ? -7.41282  -30.72624 1.61513   0.502 24.83365 ? 109 VAL A CG1  1 
ATOM   2041 C  CG1  B VAL A 1 109 ? -7.22759  -28.80985 1.68566   0.498 25.83642 ? 109 VAL A CG1  1 
ATOM   2042 C  CG2  A VAL A 1 109 ? -6.84405  -29.56425 3.72698   0.502 25.43603 ? 109 VAL A CG2  1 
ATOM   2043 C  CG2  B VAL A 1 109 ? -7.08686  -31.28609 2.28925   0.498 27.19480 ? 109 VAL A CG2  1 
ATOM   2044 H  H    A VAL A 1 109 ? -4.84315  -28.03357 2.70745   0.502 26.26705 ? 109 VAL A H    1 
ATOM   2045 H  H    B VAL A 1 109 ? -4.86539  -28.06064 2.66452   0.498 26.26568 ? 109 VAL A H    1 
ATOM   2046 H  HA   A VAL A 1 109 ? -4.79628  -30.61403 2.53001   0.502 27.88846 ? 109 VAL A HA   1 
ATOM   2047 H  HA   B VAL A 1 109 ? -4.57111  -30.67315 2.48740   0.498 26.90704 ? 109 VAL A HA   1 
ATOM   2048 H  HB   A VAL A 1 109 ? -6.85676  -28.79270 1.82200   0.502 24.57846 ? 109 VAL A HB   1 
ATOM   2049 H  HB   B VAL A 1 109 ? -6.54692  -29.67744 3.39022   0.498 31.40697 ? 109 VAL A HB   1 
ATOM   2050 H  HG11 A VAL A 1 109 ? -8.32402  -30.66084 1.94123   0.502 29.80102 ? 109 VAL A HG11 1 
ATOM   2051 H  HG11 B VAL A 1 109 ? -6.67985  -28.50699 0.94461   0.498 31.00435 ? 109 VAL A HG11 1 
ATOM   2052 H  HG12 A VAL A 1 109 ? -7.39857  -30.62436 0.65060   0.502 29.80102 ? 109 VAL A HG12 1 
ATOM   2053 H  HG12 B VAL A 1 109 ? -8.06197  -29.17550 1.35247   0.498 31.00435 ? 109 VAL A HG12 1 
ATOM   2054 H  HG13 A VAL A 1 109 ? -7.03364  -31.58402 1.86279   0.502 29.80102 ? 109 VAL A HG13 1 
ATOM   2055 H  HG13 B VAL A 1 109 ? -7.40732  -28.07090 2.28779   0.498 31.00435 ? 109 VAL A HG13 1 
ATOM   2056 H  HG21 A VAL A 1 109 ? -7.79375  -29.43929 3.87982   0.502 30.52387 ? 109 VAL A HG21 1 
ATOM   2057 H  HG21 B VAL A 1 109 ? -7.77631  -31.40525 2.96109   0.498 32.63440 ? 109 VAL A HG21 1 
ATOM   2058 H  HG22 A VAL A 1 109 ? -6.55006  -30.39455 4.13327   0.502 30.52387 ? 109 VAL A HG22 1 
ATOM   2059 H  HG22 B VAL A 1 109 ? -7.47314  -31.35851 1.40243   0.498 32.63440 ? 109 VAL A HG22 1 
ATOM   2060 H  HG23 A VAL A 1 109 ? -6.34800  -28.81923 4.10085   0.502 30.52387 ? 109 VAL A HG23 1 
ATOM   2061 H  HG23 B VAL A 1 109 ? -6.39408  -31.95526 2.40394   0.498 32.63440 ? 109 VAL A HG23 1 
ATOM   2062 N  N    . ALA A 1 110 ? -4.74531  -29.18390 -0.31542  1.000 19.15016 ? 110 ALA A N    1 
ATOM   2063 C  CA   . ALA A 1 110 ? -4.52194  -29.45495 -1.73358  1.000 19.14450 ? 110 ALA A CA   1 
ATOM   2064 C  C    . ALA A 1 110 ? -3.13192  -29.99005 -1.95819  1.000 20.39269 ? 110 ALA A C    1 
ATOM   2065 O  O    . ALA A 1 110 ? -2.91885  -30.80509 -2.86509  1.000 20.38301 ? 110 ALA A O    1 
ATOM   2066 C  CB   . ALA A 1 110 ? -4.74633  -28.20612 -2.57440  1.000 27.47367 ? 110 ALA A CB   1 
ATOM   2067 H  H    . ALA A 1 110 ? -4.83197  -28.35634 -0.09809  1.000 22.98083 ? 110 ALA A H    1 
ATOM   2068 H  HA   . ALA A 1 110 ? -5.16896  -30.11452 -2.02896  1.000 22.97404 ? 110 ALA A HA   1 
ATOM   2069 H  HB1  . ALA A 1 110 ? -4.53619  -28.40658 -3.49991  1.000 32.96904 ? 110 ALA A HB1  1 
ATOM   2070 H  HB2  . ALA A 1 110 ? -5.67472  -27.93593 -2.49704  1.000 32.96904 ? 110 ALA A HB2  1 
ATOM   2071 H  HB3  . ALA A 1 110 ? -4.16774  -27.49856 -2.24960  1.000 32.96904 ? 110 ALA A HB3  1 
ATOM   2072 N  N    . TRP A 1 111 ? -2.15794  -29.55297 -1.15830  1.000 17.37757 ? 111 TRP A N    1 
ATOM   2073 C  CA   . TRP A 1 111 ? -0.82667  -30.12595 -1.30620  1.000 17.63295 ? 111 TRP A CA   1 
ATOM   2074 C  C    . TRP A 1 111 ? -0.83221  -31.60728 -0.96923  1.000 19.02669 ? 111 TRP A C    1 
ATOM   2075 O  O    . TRP A 1 111 ? -0.29311  -32.44050 -1.71876  1.000 17.95221 ? 111 TRP A O    1 
ATOM   2076 C  CB   . TRP A 1 111 ? 0.20120   -29.38734 -0.42484  1.000 17.93014 ? 111 TRP A CB   1 
ATOM   2077 C  CG   . TRP A 1 111 ? 1.56041   -29.99167 -0.55812  1.000 17.24910 ? 111 TRP A CG   1 
ATOM   2078 C  CD1  . TRP A 1 111 ? 2.49386   -29.72477 -1.54224  1.000 19.26621 ? 111 TRP A CD1  1 
ATOM   2079 C  CD2  . TRP A 1 111 ? 2.13940   -30.99179 0.28070   1.000 16.70685 ? 111 TRP A CD2  1 
ATOM   2080 N  NE1  . TRP A 1 111 ? 3.59582   -30.53053 -1.36508  1.000 19.34575 ? 111 TRP A NE1  1 
ATOM   2081 C  CE2  . TRP A 1 111 ? 3.42598   -31.29118 -0.23906  1.000 16.15080 ? 111 TRP A CE2  1 
ATOM   2082 C  CE3  . TRP A 1 111 ? 1.71496   -31.65092 1.44954   1.000 17.89514 ? 111 TRP A CE3  1 
ATOM   2083 C  CZ2  . TRP A 1 111 ? 4.26781   -32.22202 0.37429   1.000 20.07553 ? 111 TRP A CZ2  1 
ATOM   2084 C  CZ3  . TRP A 1 111 ? 2.55467   -32.54643 2.04960   1.000 21.35713 ? 111 TRP A CZ3  1 
ATOM   2085 C  CH2  . TRP A 1 111 ? 3.81458   -32.82630 1.52134   1.000 20.86039 ? 111 TRP A CH2  1 
ATOM   2086 H  H    . TRP A 1 111 ? -2.24081  -28.95158 -0.54914  1.000 20.85373 ? 111 TRP A H    1 
ATOM   2087 H  HA   . TRP A 1 111 ? -0.55595  -30.01255 -2.23073  1.000 21.16018 ? 111 TRP A HA   1 
ATOM   2088 H  HB2  . TRP A 1 111 ? 0.25054   -28.45796 -0.69819  1.000 21.51681 ? 111 TRP A HB2  1 
ATOM   2089 H  HB3  . TRP A 1 111 ? -0.07077  -29.44585 0.50441   1.000 21.51681 ? 111 TRP A HB3  1 
ATOM   2090 H  HD1  . TRP A 1 111 ? 2.39277   -29.09663 -2.22056  1.000 23.12009 ? 111 TRP A HD1  1 
ATOM   2091 H  HE1  . TRP A 1 111 ? 4.28354   -30.55277 -1.88098  1.000 23.21554 ? 111 TRP A HE1  1 
ATOM   2092 H  HE3  . TRP A 1 111 ? 0.87441   -31.47931 1.80861   1.000 21.47481 ? 111 TRP A HE3  1 
ATOM   2093 H  HZ2  . TRP A 1 111 ? 5.10322   -32.42479 0.01950   1.000 24.09127 ? 111 TRP A HZ2  1 
ATOM   2094 H  HZ3  . TRP A 1 111 ? 2.28033   -32.97816 2.82629   1.000 25.62919 ? 111 TRP A HZ3  1 
ATOM   2095 H  HH2  . TRP A 1 111 ? 4.36244   -33.43839 1.95735   1.000 25.03310 ? 111 TRP A HH2  1 
ATOM   2096 N  N    A ARG A 1 112 ? -1.43486  -31.97410 0.16126   0.484 17.27397 ? 112 ARG A N    1 
ATOM   2097 N  N    B ARG A 1 112 ? -1.47346  -31.96757 0.13700   0.516 17.26715 ? 112 ARG A N    1 
ATOM   2098 C  CA   A ARG A 1 112 ? -1.51125  -33.37973 0.53565   0.484 18.91725 ? 112 ARG A CA   1 
ATOM   2099 C  CA   B ARG A 1 112 ? -1.49782  -33.35755 0.55199   0.516 18.79908 ? 112 ARG A CA   1 
ATOM   2100 C  C    A ARG A 1 112 ? -2.17708  -34.19813 -0.56243  0.484 18.58153 ? 112 ARG A C    1 
ATOM   2101 C  C    B ARG A 1 112 ? -2.22349  -34.22673 -0.46613  0.516 18.51661 ? 112 ARG A C    1 
ATOM   2102 O  O    A ARG A 1 112 ? -1.68585  -35.26498 -0.95678  0.484 20.26431 ? 112 ARG A O    1 
ATOM   2103 O  O    B ARG A 1 112 ? -1.83317  -35.37901 -0.69202  0.516 20.45005 ? 112 ARG A O    1 
ATOM   2104 C  CB   A ARG A 1 112 ? -2.30727  -33.52431 1.83671   0.484 23.80565 ? 112 ARG A CB   1 
ATOM   2105 C  CB   B ARG A 1 112 ? -2.16881  -33.47556 1.92148   0.516 23.58806 ? 112 ARG A CB   1 
ATOM   2106 C  CG   A ARG A 1 112 ? -2.05463  -34.81450 2.59753   0.484 33.87768 ? 112 ARG A CG   1 
ATOM   2107 C  CG   B ARG A 1 112 ? -2.08685  -34.85235 2.53656   0.516 33.70315 ? 112 ARG A CG   1 
ATOM   2108 C  CD   A ARG A 1 112 ? -2.78229  -34.82742 3.95537   0.484 41.41280 ? 112 ARG A CD   1 
ATOM   2109 C  CD   B ARG A 1 112 ? -2.35552  -34.81958 4.04717   0.516 42.73684 ? 112 ARG A CD   1 
ATOM   2110 N  NE   A ARG A 1 112 ? -3.29645  -36.14700 4.31671   0.484 43.30559 ? 112 ARG A NE   1 
ATOM   2111 N  NE   B ARG A 1 112 ? -2.92302  -33.55786 4.51130   0.516 40.28949 ? 112 ARG A NE   1 
ATOM   2112 C  CZ   A ARG A 1 112 ? -4.34437  -36.74324 3.75805   0.484 49.46742 ? 112 ARG A CZ   1 
ATOM   2113 C  CZ   B ARG A 1 112 ? -4.18209  -33.18208 4.32964   0.516 33.41113 ? 112 ARG A CZ   1 
ATOM   2114 N  NH1  A ARG A 1 112 ? -5.06617  -36.15081 2.81734   0.484 32.01664 ? 112 ARG A NH1  1 
ATOM   2115 N  NH1  B ARG A 1 112 ? -5.04137  -33.94214 3.67365   0.516 48.80090 ? 112 ARG A NH1  1 
ATOM   2116 N  NH2  A ARG A 1 112 ? -4.68223  -37.96511 4.15878   0.484 52.53582 ? 112 ARG A NH2  1 
ATOM   2117 N  NH2  B ARG A 1 112 ? -4.58993  -32.01692 4.83179   0.516 33.30697 ? 112 ARG A NH2  1 
ATOM   2118 H  H    A ARG A 1 112 ? -1.80232  -31.43413 0.72073   0.484 20.72941 ? 112 ARG A H    1 
ATOM   2119 H  H    B ARG A 1 112 ? -1.89726  -31.43044 0.65803   0.516 20.72123 ? 112 ARG A H    1 
ATOM   2120 H  HA   A ARG A 1 112 ? -0.61192  -33.71510 0.67576   0.484 22.70134 ? 112 ARG A HA   1 
ATOM   2121 H  HA   B ARG A 1 112 ? -0.58543  -33.67838 0.62627   0.516 22.55954 ? 112 ARG A HA   1 
ATOM   2122 H  HB2  A ARG A 1 112 ? -2.07338  -32.78863 2.42406   0.484 28.56742 ? 112 ARG A HB2  1 
ATOM   2123 H  HB2  B ARG A 1 112 ? -1.73955  -32.85521 2.53123   0.516 28.30631 ? 112 ARG A HB2  1 
ATOM   2124 H  HB3  A ARG A 1 112 ? -3.25313  -33.49135 1.62417   0.484 28.56742 ? 112 ARG A HB3  1 
ATOM   2125 H  HB3  B ARG A 1 112 ? -3.10779  -33.25141 1.82671   0.516 28.30631 ? 112 ARG A HB3  1 
ATOM   2126 H  HG2  A ARG A 1 112 ? -2.37666  -35.56419 2.07298   0.484 40.65385 ? 112 ARG A HG2  1 
ATOM   2127 H  HG2  B ARG A 1 112 ? -2.74935  -35.42760 2.12294   0.516 40.44443 ? 112 ARG A HG2  1 
ATOM   2128 H  HG3  A ARG A 1 112 ? -1.10326  -34.90873 2.76163   0.484 40.65385 ? 112 ARG A HG3  1 
ATOM   2129 H  HG3  B ARG A 1 112 ? -1.19814  -35.21406 2.39420   0.516 40.44443 ? 112 ARG A HG3  1 
ATOM   2130 H  HD2  A ARG A 1 112 ? -2.16263  -34.54870 4.64764   0.484 49.69600 ? 112 ARG A HD2  1 
ATOM   2131 H  HD2  B ARG A 1 112 ? -2.98220  -35.52589 4.26924   0.516 51.28484 ? 112 ARG A HD2  1 
ATOM   2132 H  HD3  A ARG A 1 112 ? -3.53340  -34.21489 3.91622   0.484 49.69600 ? 112 ARG A HD3  1 
ATOM   2133 H  HD3  B ARG A 1 112 ? -1.51854  -34.95879 4.51726   0.516 51.28484 ? 112 ARG A HD3  1 
ATOM   2134 H  HE   A ARG A 1 112 ? -2.88723  -36.57243 4.94213   0.484 51.96735 ? 112 ARG A HE   1 
ATOM   2135 H  HE   B ARG A 1 112 ? -2.40309  -33.01841 4.93352   0.516 48.34803 ? 112 ARG A HE   1 
ATOM   2136 H  HH11 A ARG A 1 112 ? -4.86077  -35.35875 2.55267   0.484 38.42061 ? 112 ARG A HH11 1 
ATOM   2137 H  HH11 B ARG A 1 112 ? -4.78855  -34.69919 3.35340   0.516 58.56172 ? 112 ARG A HH11 1 
ATOM   2138 H  HH12 A ARG A 1 112 ? -5.73990  -36.55849 2.47167   0.484 38.42061 ? 112 ARG A HH12 1 
ATOM   2139 H  HH12 B ARG A 1 112 ? -5.85338  -33.67972 3.56700   0.516 58.56172 ? 112 ARG A HH12 1 
ATOM   2140 H  HH21 A ARG A 1 112 ? -4.22468  -38.35856 4.77152   0.484 63.04363 ? 112 ARG A HH21 1 
ATOM   2141 H  HH21 B ARG A 1 112 ? -4.03926  -31.51984 5.26685   0.516 39.96900 ? 112 ARG A HH21 1 
ATOM   2142 H  HH22 A ARG A 1 112 ? -5.35831  -38.36201 3.80526   0.484 63.04363 ? 112 ARG A HH22 1 
ATOM   2143 H  HH22 B ARG A 1 112 ? -5.40378  -31.76212 4.72077   0.516 39.96900 ? 112 ARG A HH22 1 
ATOM   2144 N  N    . ASN A 1 113 ? -3.28206  -33.69449 -1.09904  1.000 18.39793 ? 113 ASN A N    1 
ATOM   2145 C  CA   . ASN A 1 113 ? -4.12923  -34.51843 -1.96048  1.000 21.04836 ? 113 ASN A CA   1 
ATOM   2146 C  C    . ASN A 1 113 ? -3.70847  -34.50319 -3.41168  1.000 23.35754 ? 113 ASN A C    1 
ATOM   2147 O  O    . ASN A 1 113 ? -4.04716  -35.44396 -4.15005  1.000 23.13454 ? 113 ASN A O    1 
ATOM   2148 C  CB   . ASN A 1 113 ? -5.59292  -34.10833 -1.82923  1.000 21.11697 ? 113 ASN A CB   1 
ATOM   2149 C  CG   . ASN A 1 113 ? -6.16597  -34.51544 -0.50228  1.000 21.25478 ? 113 ASN A CG   1 
ATOM   2150 O  OD1  . ASN A 1 113 ? -5.72033  -35.50454 0.08411   1.000 25.33325 ? 113 ASN A OD1  1 
ATOM   2151 N  ND2  . ASN A 1 113 ? -7.14173  -33.77856 -0.01554  1.000 22.16599 ? 113 ASN A ND2  1 
ATOM   2152 H  H    . ASN A 1 113 ? -3.52232  -32.87064 -1.04304  1.000 22.07816 ? 113 ASN A H    1 
ATOM   2153 H  HA   . ASN A 1 113 ? -4.06729  -35.43838 -1.65924  1.000 25.25867 ? 113 ASN A HA   1 
ATOM   2154 H  HB2  . ASN A 1 113 ? -5.66375  -33.14418 -1.90863  1.000 25.34101 ? 113 ASN A HB2  1 
ATOM   2155 H  HB3  . ASN A 1 113 ? -6.10980  -34.53768 -2.52879  1.000 25.34101 ? 113 ASN A HB3  1 
ATOM   2156 H  HD21 . ASN A 1 113 ? -7.49579  -33.97976 0.74193   1.000 26.59983 ? 113 ASN A HD21 1 
ATOM   2157 H  HD22 . ASN A 1 113 ? -7.42529  -33.09583 -0.45494  1.000 26.59983 ? 113 ASN A HD22 1 
ATOM   2158 N  N    . ARG A 1 114 ? -2.92156  -33.51283 -3.83855  1.000 19.85198 ? 114 ARG A N    1 
ATOM   2159 C  CA   . ARG A 1 114 ? -2.64768  -33.29918 -5.25907  1.000 20.61015 ? 114 ARG A CA   1 
ATOM   2160 C  C    . ARG A 1 114 ? -1.18854  -33.10916 -5.59036  1.000 21.51658 ? 114 ARG A C    1 
ATOM   2161 O  O    . ARG A 1 114 ? -0.83348  -33.21471 -6.77569  1.000 23.09230 ? 114 ARG A O    1 
ATOM   2162 C  CB   . ARG A 1 114 ? -3.44371  -32.11557 -5.76805  1.000 22.29244 ? 114 ARG A CB   1 
ATOM   2163 C  CG   . ARG A 1 114 ? -4.92127  -32.36801 -5.45426  1.000 23.58507 ? 114 ARG A CG   1 
ATOM   2164 C  CD   . ARG A 1 114 ? -5.77452  -31.35017 -6.01666  1.000 26.18138 ? 114 ARG A CD   1 
ATOM   2165 N  NE   . ARG A 1 114 ? -5.89743  -31.44476 -7.45660  1.000 23.41338 ? 114 ARG A NE   1 
ATOM   2166 C  CZ   . ARG A 1 114 ? -6.65512  -30.60985 -8.14315  1.000 23.16301 ? 114 ARG A CZ   1 
ATOM   2167 N  NH1  . ARG A 1 114 ? -7.30849  -29.64080 -7.53809  1.000 24.21763 ? 114 ARG A NH1  1 
ATOM   2168 N  NH2  . ARG A 1 114 ? -6.75271  -30.75215 -9.45717  1.000 26.28451 ? 114 ARG A NH2  1 
ATOM   2169 H  H    . ARG A 1 114 ? -2.53225  -32.94771 -3.32023  1.000 23.82302 ? 114 ARG A H    1 
ATOM   2170 H  HA   . ARG A 1 114 ? -2.94083  -34.08093 -5.75286  1.000 24.73282 ? 114 ARG A HA   1 
ATOM   2171 H  HB2  . ARG A 1 114 ? -3.15603  -31.30347 -5.32237  1.000 26.75156 ? 114 ARG A HB2  1 
ATOM   2172 H  HB3  . ARG A 1 114 ? -3.33106  -32.02533 -6.72725  1.000 26.75156 ? 114 ARG A HB3  1 
ATOM   2173 H  HG2  . ARG A 1 114 ? -5.18517  -33.22396 -5.82656  1.000 28.30273 ? 114 ARG A HG2  1 
ATOM   2174 H  HG3  . ARG A 1 114 ? -5.04750  -32.37144 -4.49252  1.000 28.30273 ? 114 ARG A HG3  1 
ATOM   2175 H  HD2  . ARG A 1 114 ? -6.66208  -31.43685 -5.63504  1.000 31.41830 ? 114 ARG A HD2  1 
ATOM   2176 H  HD3  . ARG A 1 114 ? -5.40620  -30.47808 -5.80522  1.000 31.41830 ? 114 ARG A HD3  1 
ATOM   2177 H  HE   . ARG A 1 114 ? -5.46607  -32.06013 -7.87475  1.000 28.09669 ? 114 ARG A HE   1 
ATOM   2178 H  HH11 . ARG A 1 114 ? -7.24457  -29.54592 -6.68573  1.000 29.06180 ? 114 ARG A HH11 1 
ATOM   2179 H  HH12 . ARG A 1 114 ? -7.79936  -29.10245 -7.99507  1.000 29.06180 ? 114 ARG A HH12 1 
ATOM   2180 H  HH21 . ARG A 1 114 ? -6.32479  -31.38366 -9.85425  1.000 31.54205 ? 114 ARG A HH21 1 
ATOM   2181 H  HH22 . ARG A 1 114 ? -7.24396  -30.21298 -9.91277  1.000 31.54205 ? 114 ARG A HH22 1 
ATOM   2182 N  N    . CYS A 1 115 ? -0.31629  -32.92683 -4.59303  1.000 17.58783 ? 115 CYS A N    1 
ATOM   2183 C  CA   . CYS A 1 115 ? 1.09432   -32.69267 -4.84233  1.000 18.75394 ? 115 CYS A CA   1 
ATOM   2184 C  C    . CYS A 1 115 ? 1.97750   -33.71684 -4.16743  1.000 20.00278 ? 115 CYS A C    1 
ATOM   2185 O  O    . CYS A 1 115 ? 2.95392   -34.19296 -4.77252  1.000 21.26278 ? 115 CYS A O    1 
ATOM   2186 C  CB   . CYS A 1 115 ? 1.53783   -31.28785 -4.35150  1.000 17.25845 ? 115 CYS A CB   1 
ATOM   2187 S  SG   . CYS A 1 115 ? 0.58364   -29.93960 -5.10114  1.000 18.88716 ? 115 CYS A SG   1 
ATOM   2188 H  H    . CYS A 1 115 ? -0.52739  -32.93592 -3.75939  1.000 21.10604 ? 115 CYS A H    1 
ATOM   2189 H  HA   . CYS A 1 115 ? 1.23020   -32.72376 -5.80226  1.000 22.50537 ? 115 CYS A HA   1 
ATOM   2190 H  HB2  . CYS A 1 115 ? 1.42007   -31.23911 -3.38990  1.000 20.71079 ? 115 CYS A HB2  1 
ATOM   2191 H  HB3  . CYS A 1 115 ? 2.47160   -31.15579 -4.57850  1.000 20.71079 ? 115 CYS A HB3  1 
ATOM   2192 N  N    . LYS A 1 116 ? 1.66072   -34.07947 -2.93187  1.000 19.24236 ? 116 LYS A N    1 
ATOM   2193 C  CA   . LYS A 1 116 ? 2.47088   -35.00371 -2.15583  1.000 20.34800 ? 116 LYS A CA   1 
ATOM   2194 C  C    . LYS A 1 116 ? 2.58372   -36.32649 -2.88818  1.000 21.58712 ? 116 LYS A C    1 
ATOM   2195 O  O    . LYS A 1 116 ? 1.58086   -36.88653 -3.32338  1.000 22.99776 ? 116 LYS A O    1 
ATOM   2196 C  CB   . LYS A 1 116 ? 1.80358   -35.19907 -0.79709  1.000 21.03131 ? 116 LYS A CB   1 
ATOM   2197 C  CG   . LYS A 1 116 ? 2.59557   -36.02528 0.19113   1.000 20.75923 ? 116 LYS A CG   1 
ATOM   2198 C  CD   . LYS A 1 116 ? 1.83269   -36.16990 1.50005   1.000 21.17508 ? 116 LYS A CD   1 
ATOM   2199 C  CE   . LYS A 1 116 ? 2.67967   -36.78490 2.60522   1.000 23.42208 ? 116 LYS A CE   1 
ATOM   2200 N  NZ   . LYS A 1 116 ? 1.91357   -36.82637 3.89484   1.000 24.80486 ? 116 LYS A NZ   1 
ATOM   2201 H  H    . LYS A 1 116 ? 0.96580   -33.79806 -2.51057  1.000 23.09147 ? 116 LYS A H    1 
ATOM   2202 H  HA   . LYS A 1 116 ? 3.36680   -34.65621 -2.02367  1.000 24.41825 ? 116 LYS A HA   1 
ATOM   2203 H  HB2  . LYS A 1 116 ? 1.65969   -34.32695 -0.39758  1.000 25.23821 ? 116 LYS A HB2  1 
ATOM   2204 H  HB3  . LYS A 1 116 ? 0.95343   -35.64560 -0.93402  1.000 25.23821 ? 116 LYS A HB3  1 
ATOM   2205 H  HG2  . LYS A 1 116 ? 2.75024   -36.90993 -0.17544  1.000 24.91172 ? 116 LYS A HG2  1 
ATOM   2206 H  HG3  . LYS A 1 116 ? 3.44251   -35.58919 0.37397   1.000 24.91172 ? 116 LYS A HG3  1 
ATOM   2207 H  HD2  . LYS A 1 116 ? 1.54262   -35.29310 1.79667   1.000 25.41073 ? 116 LYS A HD2  1 
ATOM   2208 H  HD3  . LYS A 1 116 ? 1.06333   -36.74309 1.35711   1.000 25.41073 ? 116 LYS A HD3  1 
ATOM   2209 H  HE2  . LYS A 1 116 ? 2.92330   -37.69155 2.36123   1.000 28.10713 ? 116 LYS A HE2  1 
ATOM   2210 H  HE3  . LYS A 1 116 ? 3.47856   -36.25086 2.73740   1.000 28.10713 ? 116 LYS A HE3  1 
ATOM   2211 H  HZ1  . LYS A 1 116 ? 2.37832   -37.26980 4.51086   1.000 29.76648 ? 116 LYS A HZ1  1 
ATOM   2212 H  HZ2  . LYS A 1 116 ? 1.76339   -35.99900 4.18642   1.000 29.76648 ? 116 LYS A HZ2  1 
ATOM   2213 H  HZ3  . LYS A 1 116 ? 1.13280   -37.23553 3.77206   1.000 29.76648 ? 116 LYS A HZ3  1 
ATOM   2214 N  N    . GLY A 1 117 ? 3.81445   -36.76852 -3.08012  1.000 23.95246 ? 117 GLY A N    1 
ATOM   2215 C  CA   . GLY A 1 117 ? 4.05339   -38.05204 -3.72310  1.000 25.30918 ? 117 GLY A CA   1 
ATOM   2216 C  C    . GLY A 1 117 ? 3.96734   -38.03175 -5.23279  1.000 30.22690 ? 117 GLY A C    1 
ATOM   2217 O  O    . GLY A 1 117 ? 3.85318   -39.10092 -5.85284  1.000 34.04011 ? 117 GLY A O    1 
ATOM   2218 H  H    . GLY A 1 117 ? 4.52740   -36.34697 -2.84862  1.000 28.74360 ? 117 GLY A H    1 
ATOM   2219 H  HA2  . GLY A 1 117 ? 4.94079   -38.36021 -3.48133  1.000 30.37166 ? 117 GLY A HA2  1 
ATOM   2220 H  HA3  . GLY A 1 117 ? 3.39831   -38.68919 -3.39783  1.000 30.37166 ? 117 GLY A HA3  1 
ATOM   2221 N  N    . THR A 1 118 ? 3.97921   -36.85976 -5.84252  1.000 26.35688 ? 118 THR A N    1 
ATOM   2222 C  CA   . THR A 1 118 ? 4.01117   -36.71113 -7.28677  1.000 25.62430 ? 118 THR A CA   1 
ATOM   2223 C  C    . THR A 1 118 ? 5.33649   -36.07742 -7.67205  1.000 24.44208 ? 118 THR A C    1 
ATOM   2224 O  O    . THR A 1 118 ? 6.13533   -35.67168 -6.82262  1.000 25.74112 ? 118 THR A O    1 
ATOM   2225 C  CB   . THR A 1 118 ? 2.85845   -35.84274 -7.80190  1.000 27.39953 ? 118 THR A CB   1 
ATOM   2226 O  OG1  . THR A 1 118 ? 3.11318   -34.45653 -7.48920  1.000 26.13919 ? 118 THR A OG1  1 
ATOM   2227 C  CG2  . THR A 1 118 ? 1.53757   -36.26532 -7.20489  1.000 27.14859 ? 118 THR A CG2  1 
ATOM   2228 H  H    . THR A 1 118 ? 3.96881   -36.10765 -5.42560  1.000 31.62890 ? 118 THR A H    1 
ATOM   2229 H  HA   . THR A 1 118 ? 3.91943   -37.58421 -7.69933  1.000 30.74980 ? 118 THR A HA   1 
ATOM   2230 H  HB   . THR A 1 118 ? 2.79171   -35.94940 -8.76370  1.000 32.88008 ? 118 THR A HB   1 
ATOM   2231 H  HG1  . THR A 1 118 ? 3.33025   -34.37943 -6.68140  1.000 31.36767 ? 118 THR A HG1  1 
ATOM   2232 H  HG21 . THR A 1 118 ? 0.82482   -35.70123 -7.54354  1.000 32.57895 ? 118 THR A HG21 1 
ATOM   2233 H  HG22 . THR A 1 118 ? 1.34752   -37.18728 -7.43893  1.000 32.57895 ? 118 THR A HG22 1 
ATOM   2234 H  HG23 . THR A 1 118 ? 1.56968   -36.18601 -6.23867  1.000 32.57895 ? 118 THR A HG23 1 
ATOM   2235 N  N    . ASP A 1 119 ? 5.55548   -35.98691 -8.98452  1.000 28.16744 ? 119 ASP A N    1 
ATOM   2236 C  CA   . ASP A 1 119 ? 6.80723   -35.43733 -9.50436  1.000 27.80289 ? 119 ASP A CA   1 
ATOM   2237 C  C    . ASP A 1 119 ? 6.68422   -33.92139 -9.48640  1.000 28.24916 ? 119 ASP A C    1 
ATOM   2238 O  O    . ASP A 1 119 ? 6.40969   -33.27390 -10.49650 1.000 30.53090 ? 119 ASP A O    1 
ATOM   2239 C  CB   . ASP A 1 119 ? 7.07966   -35.96602 -10.90738 1.000 37.53629 ? 119 ASP A CB   1 
ATOM   2240 C  CG   . ASP A 1 119 ? 8.32409   -35.35767 -11.52005 1.000 54.73446 ? 119 ASP A CG   1 
ATOM   2241 O  OD1  . ASP A 1 119 ? 9.23193   -34.97516 -10.74510 1.000 44.21539 ? 119 ASP A OD1  1 
ATOM   2242 O  OD2  . ASP A 1 119 ? 8.39104   -35.26212 -12.76806 1.000 49.53387 ? 119 ASP A OD2  1 
ATOM   2243 H  H    . ASP A 1 119 ? 4.99748   -36.23576 -9.58976  1.000 33.80157 ? 119 ASP A H    1 
ATOM   2244 H  HA   . ASP A 1 119 ? 7.54685   -35.70066 -8.93470  1.000 33.36411 ? 119 ASP A HA   1 
ATOM   2245 H  HB2  . ASP A 1 119 ? 7.20254   -36.92733 -10.86637 1.000 45.04418 ? 119 ASP A HB2  1 
ATOM   2246 H  HB3  . ASP A 1 119 ? 6.32612   -35.75199 -11.47945 1.000 45.04418 ? 119 ASP A HB3  1 
ATOM   2247 N  N    . VAL A 1 120 ? 6.92635   -33.33522 -8.30898  1.000 27.80187 ? 120 VAL A N    1 
ATOM   2248 C  CA   . VAL A 1 120 ? 6.66068   -31.89923 -8.18355  1.000 25.13503 ? 120 VAL A CA   1 
ATOM   2249 C  C    . VAL A 1 120 ? 7.69627   -31.05737 -8.91776  1.000 24.98359 ? 120 VAL A C    1 
ATOM   2250 O  O    . VAL A 1 120 ? 7.45574   -29.87268 -9.17901  1.000 25.22505 ? 120 VAL A O    1 
ATOM   2251 C  CB   . VAL A 1 120 ? 6.57339   -31.45987 -6.71382  1.000 24.09223 ? 120 VAL A CB   1 
ATOM   2252 C  CG1  . VAL A 1 120 ? 5.36927   -32.09788 -6.03032  1.000 27.72701 ? 120 VAL A CG1  1 
ATOM   2253 C  CG2  . VAL A 1 120 ? 7.81167   -31.81551 -5.96887  1.000 27.72531 ? 120 VAL A CG2  1 
ATOM   2254 H  H    . VAL A 1 120 ? 7.22843   -33.72589 -7.60490  1.000 33.36288 ? 120 VAL A H    1 
ATOM   2255 H  HA   . VAL A 1 120 ? 5.79400   -31.74263 -8.59006  1.000 30.16268 ? 120 VAL A HA   1 
ATOM   2256 H  HB   . VAL A 1 120 ? 6.47195   -30.49530 -6.69934  1.000 28.91132 ? 120 VAL A HB   1 
ATOM   2257 H  HG11 . VAL A 1 120 ? 5.40224   -31.89838 -5.08163  1.000 33.27305 ? 120 VAL A HG11 1 
ATOM   2258 H  HG12 . VAL A 1 120 ? 4.55734   -31.73415 -6.41680  1.000 33.27305 ? 120 VAL A HG12 1 
ATOM   2259 H  HG13 . VAL A 1 120 ? 5.39993   -33.05760 -6.16778  1.000 33.27305 ? 120 VAL A HG13 1 
ATOM   2260 H  HG21 . VAL A 1 120 ? 7.70715   -31.55564 -5.04019  1.000 33.27101 ? 120 VAL A HG21 1 
ATOM   2261 H  HG22 . VAL A 1 120 ? 7.95323   -32.77314 -6.03047  1.000 33.27101 ? 120 VAL A HG22 1 
ATOM   2262 H  HG23 . VAL A 1 120 ? 8.56292   -31.34414 -6.36172  1.000 33.27101 ? 120 VAL A HG23 1 
ATOM   2263 N  N    . GLN A 1 121 ? 8.87648   -31.61137 -9.23167  1.000 26.11902 ? 121 GLN A N    1 
ATOM   2264 C  CA   . GLN A 1 121 ? 9.84285   -30.84520 -10.00396 1.000 26.35576 ? 121 GLN A CA   1 
ATOM   2265 C  C    . GLN A 1 121 ? 9.29549   -30.45431 -11.36943 1.000 24.69061 ? 121 GLN A C    1 
ATOM   2266 O  O    . GLN A 1 121 ? 9.76947   -29.48174 -11.96778 1.000 27.29654 ? 121 GLN A O    1 
ATOM   2267 C  CB   . GLN A 1 121 ? 11.14689  -31.63436 -10.17979 1.000 41.93533 ? 121 GLN A CB   1 
ATOM   2268 C  CG   . GLN A 1 121 ? 12.32434  -30.78304 -10.68972 1.000 64.75764 ? 121 GLN A CG   1 
ATOM   2269 C  CD   . GLN A 1 121 ? 12.53263  -30.84270 -12.19938 1.000 84.04311 ? 121 GLN A CD   1 
ATOM   2270 O  OE1  . GLN A 1 121 ? 12.27711  -31.86522 -12.83946 1.000 79.58198 ? 121 GLN A OE1  1 
ATOM   2271 N  NE2  . GLN A 1 121 ? 13.03855  -29.74799 -12.76812 1.000 66.72388 ? 121 GLN A NE2  1 
ATOM   2272 H  H    . GLN A 1 121 ? 9.12730   -32.40442 -9.01312  1.000 31.34347 ? 121 GLN A H    1 
ATOM   2273 H  HA   . GLN A 1 121 ? 10.05315  -30.03635 -9.51159  1.000 31.62755 ? 121 GLN A HA   1 
ATOM   2274 H  HB2  . GLN A 1 121 ? 11.40225  -32.00934 -9.32242  1.000 50.32303 ? 121 GLN A HB2  1 
ATOM   2275 H  HB3  . GLN A 1 121 ? 10.99640  -32.34598 -10.82154 1.000 50.32303 ? 121 GLN A HB3  1 
ATOM   2276 H  HG2  . GLN A 1 121 ? 12.16333  -29.85653 -10.45194 1.000 77.70981 ? 121 GLN A HG2  1 
ATOM   2277 H  HG3  . GLN A 1 121 ? 13.13967  -31.09686 -10.26822 1.000 77.70981 ? 121 GLN A HG3  1 
ATOM   2278 H  HE21 . GLN A 1 121 ? 13.22754  -29.06123 -12.28621 1.000 80.06930 ? 121 GLN A HE21 1 
ATOM   2279 H  HE22 . GLN A 1 121 ? 13.17587  -29.72868 -13.61687 1.000 80.06930 ? 121 GLN A HE22 1 
ATOM   2280 N  N    . ALA A 1 122 ? 8.29501   -31.16781 -11.87802 1.000 26.30157 ? 122 ALA A N    1 
ATOM   2281 C  CA   . ALA A 1 122 ? 7.69645   -30.78296 -13.14860 1.000 26.44051 ? 122 ALA A CA   1 
ATOM   2282 C  C    . ALA A 1 122 ? 7.17325   -29.35207 -13.11017 1.000 26.59290 ? 122 ALA A C    1 
ATOM   2283 O  O    . ALA A 1 122 ? 7.06152   -28.69217 -14.15023 1.000 26.90106 ? 122 ALA A O    1 
ATOM   2284 C  CB   . ALA A 1 122 ? 6.56011   -31.73232 -13.51220 1.000 33.84875 ? 122 ALA A CB   1 
ATOM   2285 H  H    . ALA A 1 122 ? 7.95078   -31.86653 -11.51348 1.000 31.56253 ? 122 ALA A H    1 
ATOM   2286 H  HA   . ALA A 1 122 ? 8.37746   -30.84648 -13.83642 1.000 31.72925 ? 122 ALA A HA   1 
ATOM   2287 H  HB1  . ALA A 1 122 ? 6.18323   -31.46211 -14.36417 1.000 40.61914 ? 122 ALA A HB1  1 
ATOM   2288 H  HB2  . ALA A 1 122 ? 6.91072   -32.63443 -13.57681 1.000 40.61914 ? 122 ALA A HB2  1 
ATOM   2289 H  HB3  . ALA A 1 122 ? 5.88030   -31.69033 -12.82155 1.000 40.61914 ? 122 ALA A HB3  1 
ATOM   2290 N  N    . TRP A 1 123 ? 6.81381   -28.86471 -11.91903 1.000 25.22182 ? 123 TRP A N    1 
ATOM   2291 C  CA   . TRP A 1 123 ? 6.20742   -27.54277 -11.82420 1.000 24.40636 ? 123 TRP A CA   1 
ATOM   2292 C  C    . TRP A 1 123 ? 7.20557   -26.42346 -12.06007 1.000 22.44219 ? 123 TRP A C    1 
ATOM   2293 O  O    . TRP A 1 123 ? 6.78167   -25.28592 -12.30795 1.000 26.79043 ? 123 TRP A O    1 
ATOM   2294 C  CB   . TRP A 1 123 ? 5.50935   -27.36464 -10.44834 1.000 20.31499 ? 123 TRP A CB   1 
ATOM   2295 C  CG   . TRP A 1 123 ? 4.25654   -28.15707 -10.40489 1.000 22.95376 ? 123 TRP A CG   1 
ATOM   2296 C  CD1  . TRP A 1 123 ? 4.09399   -29.37337 -9.83472  1.000 26.33425 ? 123 TRP A CD1  1 
ATOM   2297 C  CD2  . TRP A 1 123 ? 3.01609   -27.81376 -10.99822 1.000 20.48878 ? 123 TRP A CD2  1 
ATOM   2298 N  NE1  . TRP A 1 123 ? 2.82089   -29.82704 -10.05356 1.000 26.36816 ? 123 TRP A NE1  1 
ATOM   2299 C  CE2  . TRP A 1 123 ? 2.14058   -28.89362 -10.77335 1.000 22.84659 ? 123 TRP A CE2  1 
ATOM   2300 C  CE3  . TRP A 1 123 ? 2.57215   -26.72586 -11.74807 1.000 25.29742 ? 123 TRP A CE3  1 
ATOM   2301 C  CZ2  . TRP A 1 123 ? 0.83585   -28.88614 -11.21868 1.000 29.93899 ? 123 TRP A CZ2  1 
ATOM   2302 C  CZ3  . TRP A 1 123 ? 1.27304   -26.72537 -12.20472 1.000 33.34395 ? 123 TRP A CZ3  1 
ATOM   2303 C  CH2  . TRP A 1 123 ? 0.42533   -27.80447 -11.93890 1.000 29.04246 ? 123 TRP A CH2  1 
ATOM   2304 H  H    . TRP A 1 123 ? 6.90977   -29.27367 -11.16860 1.000 30.26682 ? 123 TRP A H    1 
ATOM   2305 H  HA   . TRP A 1 123 ? 5.52406   -27.47025 -12.50878 1.000 29.28827 ? 123 TRP A HA   1 
ATOM   2306 H  HB2  . TRP A 1 123 ? 6.09783   -27.67385 -9.74196  1.000 24.37863 ? 123 TRP A HB2  1 
ATOM   2307 H  HB3  . TRP A 1 123 ? 5.29089   -26.42937 -10.31251 1.000 24.37863 ? 123 TRP A HB3  1 
ATOM   2308 H  HD1  . TRP A 1 123 ? 4.75055   -29.83353 -9.36346  1.000 31.60174 ? 123 TRP A HD1  1 
ATOM   2309 H  HE1  . TRP A 1 123 ? 2.50330   -30.57833 -9.78099  1.000 31.64243 ? 123 TRP A HE1  1 
ATOM   2310 H  HE3  . TRP A 1 123 ? 3.14157   -26.01501 -11.93610 1.000 30.35755 ? 123 TRP A HE3  1 
ATOM   2311 H  HZ2  . TRP A 1 123 ? 0.25846   -29.59162 -11.03480 1.000 35.92743 ? 123 TRP A HZ2  1 
ATOM   2312 H  HZ3  . TRP A 1 123 ? 0.95689   -26.00064 -12.69432 1.000 40.01338 ? 123 TRP A HZ3  1 
ATOM   2313 H  HH2  . TRP A 1 123 ? -0.44589  -27.78365 -12.26360 1.000 34.85159 ? 123 TRP A HH2  1 
ATOM   2314 N  N    . ILE A 1 124 ? 8.50704   -26.71551 -11.98602 1.000 23.02385 ? 124 ILE A N    1 
ATOM   2315 C  CA   . ILE A 1 124 ? 9.52130   -25.71840 -12.27358 1.000 24.07663 ? 124 ILE A CA   1 
ATOM   2316 C  C    . ILE A 1 124 ? 10.30900  -26.03730 -13.53786 1.000 25.03110 ? 124 ILE A C    1 
ATOM   2317 O  O    . ILE A 1 124 ? 11.23902  -25.29795 -13.87107 1.000 26.73143 ? 124 ILE A O    1 
ATOM   2318 C  CB   . ILE A 1 124 ? 10.42300  -25.44713 -11.05879 1.000 25.95552 ? 124 ILE A CB   1 
ATOM   2319 C  CG1  . ILE A 1 124 ? 11.14830  -26.70118 -10.60173 1.000 31.01808 ? 124 ILE A CG1  1 
ATOM   2320 C  CG2  . ILE A 1 124 ? 9.58044   -24.87394 -9.88693  1.000 29.31705 ? 124 ILE A CG2  1 
ATOM   2321 C  CD1  . ILE A 1 124 ? 12.27533  -26.41122 -9.62017  1.000 41.22273 ? 124 ILE A CD1  1 
ATOM   2322 H  H    . ILE A 1 124 ? 8.81970   -27.48712 -11.77048 1.000 27.62926 ? 124 ILE A H    1 
ATOM   2323 H  HA   . ILE A 1 124 ? 9.06936   -24.87974 -12.45605 1.000 28.89259 ? 124 ILE A HA   1 
ATOM   2324 H  HB   . ILE A 1 124 ? 11.09044  -24.79909 -11.33349 1.000 31.14726 ? 124 ILE A HB   1 
ATOM   2325 H  HG12 . ILE A 1 124 ? 10.51391  -27.28995 -10.16379 1.000 37.22233 ? 124 ILE A HG12 1 
ATOM   2326 H  HG13 . ILE A 1 124 ? 11.53149  -27.14306 -11.37555 1.000 37.22233 ? 124 ILE A HG13 1 
ATOM   2327 H  HG21 . ILE A 1 124 ? 10.17334  -24.64477 -9.15423  1.000 35.18110 ? 124 ILE A HG21 1 
ATOM   2328 H  HG22 . ILE A 1 124 ? 9.11142   -24.08197 -10.19303 1.000 35.18110 ? 124 ILE A HG22 1 
ATOM   2329 H  HG23 . ILE A 1 124 ? 8.94254   -25.54541 -9.59863  1.000 35.18110 ? 124 ILE A HG23 1 
ATOM   2330 H  HD11 . ILE A 1 124 ? 12.71961  -27.24348 -9.39463  1.000 49.46791 ? 124 ILE A HD11 1 
ATOM   2331 H  HD12 . ILE A 1 124 ? 12.90576  -25.80140 -10.03437 1.000 49.46791 ? 124 ILE A HD12 1 
ATOM   2332 H  HD13 . ILE A 1 124 ? 11.90196  -26.00835 -8.82067  1.000 49.46791 ? 124 ILE A HD13 1 
ATOM   2333 N  N    A ARG A 1 125 ? 9.94553   -27.08912 -14.26823 0.437 24.89259 ? 125 ARG A N    1 
ATOM   2334 N  N    B ARG A 1 125 ? 9.91289   -27.07464 -14.27596 0.563 24.62547 ? 125 ARG A N    1 
ATOM   2335 C  CA   A ARG A 1 125 ? 10.71287  -27.47716 -15.44589 0.437 32.86040 ? 125 ARG A CA   1 
ATOM   2336 C  CA   B ARG A 1 125 ? 10.61324  -27.45509 -15.49609 0.563 33.02481 ? 125 ARG A CA   1 
ATOM   2337 C  C    A ARG A 1 125 ? 10.57517  -26.41823 -16.53218 0.437 31.12995 ? 125 ARG A C    1 
ATOM   2338 C  C    B ARG A 1 125 ? 10.57631  -26.30430 -16.48836 0.563 30.98898 ? 125 ARG A C    1 
ATOM   2339 O  O    A ARG A 1 125 ? 9.47546   -25.94138 -16.82262 0.437 33.36451 ? 125 ARG A O    1 
ATOM   2340 O  O    B ARG A 1 125 ? 9.55418   -25.63092 -16.65201 0.563 33.04564 ? 125 ARG A O    1 
ATOM   2341 C  CB   A ARG A 1 125 ? 10.23171  -28.83123 -15.97470 0.437 41.95225 ? 125 ARG A CB   1 
ATOM   2342 C  CB   B ARG A 1 125 ? 9.93245   -28.67453 -16.12674 0.563 40.08423 ? 125 ARG A CB   1 
ATOM   2343 C  CG   A ARG A 1 125 ? 10.88594  -30.03443 -15.29833 0.437 58.91735 ? 125 ARG A CG   1 
ATOM   2344 C  CG   B ARG A 1 125 ? 10.87289  -29.81758 -16.51180 0.563 58.32552 ? 125 ARG A CG   1 
ATOM   2345 C  CD   A ARG A 1 125 ? 10.98133  -31.25247 -16.22896 0.437 67.46017 ? 125 ARG A CD   1 
ATOM   2346 C  CD   B ARG A 1 125 ? 10.95094  -30.90577 -15.43004 0.563 67.66196 ? 125 ARG A CD   1 
ATOM   2347 N  NE   A ARG A 1 125 ? 10.29035  -32.42690 -15.70171 0.437 72.57352 ? 125 ARG A NE   1 
ATOM   2348 N  NE   B ARG A 1 125 ? 10.32457  -32.15433 -15.85594 0.563 73.19491 ? 125 ARG A NE   1 
ATOM   2349 C  CZ   A ARG A 1 125 ? 9.12236   -32.88621 -16.13784 0.437 65.24602 ? 125 ARG A CZ   1 
ATOM   2350 C  CZ   B ARG A 1 125 ? 10.16369  -33.22222 -15.08406 0.563 67.30079 ? 125 ARG A CZ   1 
ATOM   2351 N  NH1  A ARG A 1 125 ? 8.45559   -32.28271 -17.10899 0.437 60.04944 ? 125 ARG A NH1  1 
ATOM   2352 N  NH1  B ARG A 1 125 ? 10.54563  -33.22580 -13.81703 0.563 50.74211 ? 125 ARG A NH1  1 
ATOM   2353 N  NH2  A ARG A 1 125 ? 8.61089   -33.98287 -15.58614 0.437 62.92136 ? 125 ARG A NH2  1 
ATOM   2354 N  NH2  B ARG A 1 125 ? 9.60422   -34.31580 -15.59697 0.563 69.58358 ? 125 ARG A NH2  1 
ATOM   2355 H  H    A ARG A 1 125 ? 9.26532   -27.58915 -14.10423 0.437 29.87175 ? 125 ARG A H    1 
ATOM   2356 H  H    B ARG A 1 125 ? 9.23875   -27.57506 -14.08966 0.563 29.55121 ? 125 ARG A H    1 
ATOM   2357 H  HA   A ARG A 1 125 ? 11.64976  -27.56163 -15.20925 0.437 39.43312 ? 125 ARG A HA   1 
ATOM   2358 H  HA   B ARG A 1 125 ? 11.53452  -27.67716 -15.28914 0.563 39.63041 ? 125 ARG A HA   1 
ATOM   2359 H  HB2  A ARG A 1 125 ? 9.27455   -28.89767 -15.83212 0.437 50.34334 ? 125 ARG A HB2  1 
ATOM   2360 H  HB2  B ARG A 1 125 ? 9.28979   -29.02876 -15.49238 0.563 48.10172 ? 125 ARG A HB2  1 
ATOM   2361 H  HB3  A ARG A 1 125 ? 10.43023  -28.88239 -16.92279 0.437 50.34334 ? 125 ARG A HB3  1 
ATOM   2362 H  HB3  B ARG A 1 125 ? 9.47805   -28.38808 -16.93443 0.563 48.10172 ? 125 ARG A HB3  1 
ATOM   2363 H  HG2  A ARG A 1 125 ? 11.78495  -29.79448 -15.02425 0.437 70.70146 ? 125 ARG A HG2  1 
ATOM   2364 H  HG2  B ARG A 1 125 ? 10.55339  -30.22949 -17.32982 0.563 69.99126 ? 125 ARG A HG2  1 
ATOM   2365 H  HG3  A ARG A 1 125 ? 10.35968  -30.28827 -14.52404 0.437 70.70146 ? 125 ARG A HG3  1 
ATOM   2366 H  HG3  B ARG A 1 125 ? 11.76559  -29.46259 -16.64583 0.563 69.99126 ? 125 ARG A HG3  1 
ATOM   2367 H  HD2  A ARG A 1 125 ? 10.58113  -31.02872 -17.08375 0.437 80.95284 ? 125 ARG A HD2  1 
ATOM   2368 H  HD2  B ARG A 1 125 ? 11.88212  -31.08836 -15.22887 0.563 81.19500 ? 125 ARG A HD2  1 
ATOM   2369 H  HD3  A ARG A 1 125 ? 11.91530  -31.48448 -16.35049 0.437 80.95284 ? 125 ARG A HD3  1 
ATOM   2370 H  HD3  B ARG A 1 125 ? 10.49398  -30.59532 -14.63273 0.563 81.19500 ? 125 ARG A HD3  1 
ATOM   2371 H  HE   A ARG A 1 125 ? 10.66927  -32.85431 -15.05879 0.437 87.08887 ? 125 ARG A HE   1 
ATOM   2372 H  HE   B ARG A 1 125 ? 10.03914  -32.20116 -16.66584 0.563 87.83453 ? 125 ARG A HE   1 
ATOM   2373 H  HH11 A ARG A 1 125 ? 8.77674   -31.57386 -17.47505 0.437 72.05997 ? 125 ARG A HH11 1 
ATOM   2374 H  HH11 B ARG A 1 125 ? 10.90794  -32.52476 -13.47516 0.563 60.89118 ? 125 ARG A HH11 1 
ATOM   2375 H  HH12 A ARG A 1 125 ? 7.70121   -32.59944 -17.37394 0.437 72.05997 ? 125 ARG A HH12 1 
ATOM   2376 H  HH12 B ARG A 1 125 ? 10.43154  -33.92916 -13.33551 0.563 60.89118 ? 125 ARG A HH12 1 
ATOM   2377 H  HH21 A ARG A 1 125 ? 9.03541   -34.38509 -14.95558 0.437 75.50628 ? 125 ARG A HH21 1 
ATOM   2378 H  HH21 B ARG A 1 125 ? 9.35199   -34.32459 -16.41910 0.563 83.50094 ? 125 ARG A HH21 1 
ATOM   2379 H  HH22 A ARG A 1 125 ? 7.85562   -34.28981 -15.85992 0.437 75.50628 ? 125 ARG A HH22 1 
ATOM   2380 H  HH22 B ARG A 1 125 ? 9.49500   -35.01352 -15.10620 0.563 83.50094 ? 125 ARG A HH22 1 
ATOM   2381 N  N    . GLY A 1 126 ? 11.70945  -26.07349 -17.14997 1.000 32.56342 ? 126 GLY A N    1 
ATOM   2382 C  CA   . GLY A 1 126 ? 11.77429  -25.05115 -18.16409 1.000 36.79400 ? 126 GLY A CA   1 
ATOM   2383 C  C    . GLY A 1 126 ? 12.03505  -23.64672 -17.66833 1.000 39.71744 ? 126 GLY A C    1 
ATOM   2384 O  O    . GLY A 1 126 ? 12.38593  -22.77614 -18.47782 1.000 43.34148 ? 126 GLY A O    1 
ATOM   2385 H  H    . GLY A 1 126 ? 12.44640  -26.49847 -17.02390 1.000 39.07675 ? 126 GLY A H    1 
ATOM   2386 H  HA2  . GLY A 1 126 ? 12.48524  -25.27841 -18.78361 1.000 44.15344 ? 126 GLY A HA2  1 
ATOM   2387 H  HA3  . GLY A 1 126 ? 10.93042  -25.03960 -18.64228 1.000 44.15344 ? 126 GLY A HA3  1 
ATOM   2388 N  N    . CYS A 1 127 ? 11.90893  -23.38695 -16.37076 1.000 28.68024 ? 127 CYS A N    1 
ATOM   2389 C  CA   . CYS A 1 127 ? 11.98148  -22.02159 -15.88203 1.000 28.65000 ? 127 CYS A CA   1 
ATOM   2390 C  C    . CYS A 1 127 ? 13.42163  -21.55582 -15.68413 1.000 31.22640 ? 127 CYS A C    1 
ATOM   2391 O  O    . CYS A 1 127 ? 14.28378  -22.31034 -15.21686 1.000 31.07742 ? 127 CYS A O    1 
ATOM   2392 C  CB   . CYS A 1 127 ? 11.26706  -21.91845 -14.52986 1.000 26.65378 ? 127 CYS A CB   1 
ATOM   2393 S  SG   . CYS A 1 127 ? 9.53354   -22.44019 -14.50107 1.000 27.38873 ? 127 CYS A SG   1 
ATOM   2394 H  H    . CYS A 1 127 ? 11.78193  -23.98039 -15.76142 1.000 34.41693 ? 127 CYS A H    1 
ATOM   2395 H  HA   . CYS A 1 127 ? 11.56080  -21.44542 -16.53926 1.000 34.38064 ? 127 CYS A HA   1 
ATOM   2396 H  HB2  . CYS A 1 127 ? 11.74342  -22.47389 -13.89310 1.000 31.98518 ? 127 CYS A HB2  1 
ATOM   2397 H  HB3  . CYS A 1 127 ? 11.29145  -20.99155 -14.24497 1.000 31.98518 ? 127 CYS A HB3  1 
ATOM   2398 N  N    A ARG A 1 128 ? 13.66221  -20.28927 -16.00539 0.500 32.18439 ? 128 ARG A N    1 
ATOM   2399 N  N    B ARG A 1 128 ? 13.68628  -20.30021 -16.03151 0.500 32.20532 ? 128 ARG A N    1 
ATOM   2400 C  CA   A ARG A 1 128 ? 14.94106  -19.63724 -15.73608 0.500 41.41485 ? 128 ARG A CA   1 
ATOM   2401 C  CA   B ARG A 1 128 ? 14.99260  -19.71278 -15.74915 0.500 41.37291 ? 128 ARG A CA   1 
ATOM   2402 C  C    A ARG A 1 128 ? 14.95368  -19.21215 -14.27498 0.500 39.55583 ? 128 ARG A C    1 
ATOM   2403 C  C    B ARG A 1 128 ? 14.99602  -19.21720 -14.30902 0.500 39.50978 ? 128 ARG A C    1 
ATOM   2404 O  O    A ARG A 1 128 ? 14.30106  -18.23707 -13.89589 0.500 47.12283 ? 128 ARG A O    1 
ATOM   2405 O  O    B ARG A 1 128 ? 14.37600  -18.19714 -13.99007 0.500 47.01580 ? 128 ARG A O    1 
ATOM   2406 C  CB   A ARG A 1 128 ? 15.09340  -18.42641 -16.64792 0.500 42.64006 ? 128 ARG A CB   1 
ATOM   2407 C  CB   B ARG A 1 128 ? 15.32367  -18.58905 -16.72598 0.500 41.85845 ? 128 ARG A CB   1 
ATOM   2408 C  CG   A ARG A 1 128 ? 16.44883  -18.29296 -17.29766 0.500 50.53161 ? 128 ARG A CG   1 
ATOM   2409 C  CG   B ARG A 1 128 ? 16.82611  -18.36170 -16.86873 0.500 47.61494 ? 128 ARG A CG   1 
ATOM   2410 C  CD   A ARG A 1 128 ? 16.52412  -17.01908 -18.12932 0.500 35.81016 ? 128 ARG A CD   1 
ATOM   2411 C  CD   B ARG A 1 128 ? 17.15622  -17.21081 -17.81102 0.500 39.48000 ? 128 ARG A CD   1 
ATOM   2412 N  NE   A ARG A 1 128 ? 16.18283  -17.27222 -19.52428 0.500 33.13330 ? 128 ARG A NE   1 
ATOM   2413 N  NE   B ARG A 1 128 ? 18.59691  -17.01403 -17.94183 0.500 38.75125 ? 128 ARG A NE   1 
ATOM   2414 C  CZ   A ARG A 1 128 ? 15.38652  -16.50933 -20.26365 0.500 38.05639 ? 128 ARG A CZ   1 
ATOM   2415 C  CZ   B ARG A 1 128 ? 19.39473  -17.76081 -18.69514 0.500 48.84888 ? 128 ARG A CZ   1 
ATOM   2416 N  NH1  A ARG A 1 128 ? 14.81243  -15.42532 -19.77219 0.500 39.18917 ? 128 ARG A NH1  1 
ATOM   2417 N  NH1  B ARG A 1 128 ? 18.92797  -18.77360 -19.40789 0.500 42.53219 ? 128 ARG A NH1  1 
ATOM   2418 N  NH2  A ARG A 1 128 ? 15.16120  -16.84385 -21.52988 0.500 48.01004 ? 128 ARG A NH2  1 
ATOM   2419 N  NH2  B ARG A 1 128 ? 20.69511  -17.48267 -18.73596 0.500 49.68740 ? 128 ARG A NH2  1 
ATOM   2420 H  H    A ARG A 1 128 ? 13.08931  -19.77473 -16.38830 0.500 38.62191 ? 128 ARG A H    1 
ATOM   2421 H  H    B ARG A 1 128 ? 13.13280  -19.77406 -16.42703 0.500 38.64703 ? 128 ARG A H    1 
ATOM   2422 H  HA   A ARG A 1 128 ? 15.67315  -20.25443 -15.89102 0.500 49.69845 ? 128 ARG A HA   1 
ATOM   2423 H  HA   B ARG A 1 128 ? 15.67629  -20.39312 -15.85215 0.500 49.64813 ? 128 ARG A HA   1 
ATOM   2424 H  HB2  A ARG A 1 128 ? 14.43452  -18.48981 -17.35698 0.500 51.16871 ? 128 ARG A HB2  1 
ATOM   2425 H  HB2  B ARG A 1 128 ? 14.96867  -18.81466 -17.60004 0.500 50.23078 ? 128 ARG A HB2  1 
ATOM   2426 H  HB3  A ARG A 1 128 ? 14.94053  -17.62472 -16.12370 0.500 51.16871 ? 128 ARG A HB3  1 
ATOM   2427 H  HB3  B ARG A 1 128 ? 14.92310  -17.76489 -16.40785 0.500 50.23078 ? 128 ARG A HB3  1 
ATOM   2428 H  HG2  A ARG A 1 128 ? 17.13455  -18.25482 -16.61265 0.500 60.63857 ? 128 ARG A HG2  1 
ATOM   2429 H  HG2  B ARG A 1 128 ? 17.19963  -18.15362 -15.99805 0.500 57.13857 ? 128 ARG A HG2  1 
ATOM   2430 H  HG3  A ARG A 1 128 ? 16.60485  -19.05180 -17.88137 0.500 60.63857 ? 128 ARG A HG3  1 
ATOM   2431 H  HG3  B ARG A 1 128 ? 17.23658  -19.16640 -17.22211 0.500 57.13857 ? 128 ARG A HG3  1 
ATOM   2432 H  HD2  A ARG A 1 128 ? 15.89916  -16.36701 -17.77559 0.500 42.97283 ? 128 ARG A HD2  1 
ATOM   2433 H  HD2  B ARG A 1 128 ? 16.79473  -17.40336 -18.69030 0.500 47.37664 ? 128 ARG A HD2  1 
ATOM   2434 H  HD3  A ARG A 1 128 ? 17.42690  -16.66591 -18.09512 0.500 42.97283 ? 128 ARG A HD3  1 
ATOM   2435 H  HD3  B ARG A 1 128 ? 16.76791  -16.39218 -17.46466 0.500 47.37664 ? 128 ARG A HD3  1 
ATOM   2436 H  HE   A ARG A 1 128 ? 16.52332  -17.96877 -19.89642 0.500 39.76061 ? 128 ARG A HE   1 
ATOM   2437 H  HE   B ARG A 1 128 ? 18.95387  -16.36862 -17.49952 0.500 46.50214 ? 128 ARG A HE   1 
ATOM   2438 H  HH11 A ARG A 1 128 ? 14.95089  -15.19864 -18.95424 0.500 47.02765 ? 128 ARG A HH11 1 
ATOM   2439 H  HH11 B ARG A 1 128 ? 18.08893  -18.96142 -19.39000 0.500 51.03927 ? 128 ARG A HH11 1 
ATOM   2440 H  HH12 A ARG A 1 128 ? 14.30033  -14.94652 -20.27030 0.500 47.02765 ? 128 ARG A HH12 1 
ATOM   2441 H  HH12 B ARG A 1 128 ? 19.46372  -19.24388 -19.88894 0.500 51.03927 ? 128 ARG A HH12 1 
ATOM   2442 H  HH21 A ARG A 1 128 ? 15.52941  -17.54701 -21.86093 0.500 57.61269 ? 128 ARG A HH21 1 
ATOM   2443 H  HH21 B ARG A 1 128 ? 21.00897  -16.82600 -18.27784 0.500 59.62552 ? 128 ARG A HH21 1 
ATOM   2444 H  HH22 A ARG A 1 128 ? 14.64717  -16.35718 -22.01827 0.500 57.61269 ? 128 ARG A HH22 1 
ATOM   2445 H  HH22 B ARG A 1 128 ? 21.22183  -17.95954 -19.22048 0.500 59.62552 ? 128 ARG A HH22 1 
ATOM   2446 N  N    . LEU A 1 129 ? 15.69147  -19.94426 -13.44510 1.000 44.06207 ? 129 LEU A N    1 
ATOM   2447 C  CA   . LEU A 1 129 ? 15.74973  -19.63720 -12.01984 1.000 52.42830 ? 129 LEU A CA   1 
ATOM   2448 C  C    . LEU A 1 129 ? 17.19098  -19.43291 -11.56423 1.000 73.22025 ? 129 LEU A C    1 
ATOM   2449 O  O    . LEU A 1 129 ? 17.44890  -18.74108 -10.57791 1.000 63.23599 ? 129 LEU A O    1 
ATOM   2450 C  CB   . LEU A 1 129 ? 15.12149  -20.76971 -11.20842 1.000 47.98099 ? 129 LEU A CB   1 
ATOM   2451 C  CG   . LEU A 1 129 ? 13.64719  -21.05815 -11.49802 1.000 45.83706 ? 129 LEU A CG   1 
ATOM   2452 C  CD1  . LEU A 1 129 ? 13.18982  -22.31037 -10.75832 1.000 44.97882 ? 129 LEU A CD1  1 
ATOM   2453 C  CD2  . LEU A 1 129 ? 12.77499  -19.86337 -11.11890 1.000 46.51230 ? 129 LEU A CD2  1 
ATOM   2454 O  OXT  . LEU A 1 129 ? 18.12582  -19.96389 -12.16693 1.000 85.63920 ? 129 LEU A OXT  1 
ATOM   2455 H  H    . LEU A 1 129 ? 16.16559  -20.62145 -13.68220 1.000 52.87513 ? 129 LEU A H    1 
ATOM   2456 H  HA   . LEU A 1 129 ? 15.25359  -18.82037 -11.85391 1.000 62.91460 ? 129 LEU A HA   1 
ATOM   2457 H  HB2  . LEU A 1 129 ? 15.61566  -21.58408 -11.39145 1.000 57.57783 ? 129 LEU A HB2  1 
ATOM   2458 H  HB3  . LEU A 1 129 ? 15.19136  -20.54358 -10.26774 1.000 57.57783 ? 129 LEU A HB3  1 
ATOM   2459 H  HG   . LEU A 1 129 ? 13.54190  -21.21407 -12.44960 1.000 55.00511 ? 129 LEU A HG   1 
ATOM   2460 H  HD11 . LEU A 1 129 ? 12.25501  -22.47262 -10.96009 1.000 53.97522 ? 129 LEU A HD11 1 
ATOM   2461 H  HD12 . LEU A 1 129 ? 13.72681  -23.06352 -11.05038 1.000 53.97522 ? 129 LEU A HD12 1 
ATOM   2462 H  HD13 . LEU A 1 129 ? 13.30341  -22.17311 -9.80482  1.000 53.97522 ? 129 LEU A HD13 1 
ATOM   2463 H  HD21 . LEU A 1 129 ? 11.84714  -20.07899 -11.30195 1.000 55.81539 ? 129 LEU A HD21 1 
ATOM   2464 H  HD22 . LEU A 1 129 ? 12.89068  -19.67498 -10.17443 1.000 55.81539 ? 129 LEU A HD22 1 
ATOM   2465 H  HD23 . LEU A 1 129 ? 13.04602  -19.09491 -11.64511 1.000 55.81539 ? 129 LEU A HD23 1 
HETATM 2466 C  C1   . EDO B 2 .   ? -3.15520  -22.65869 5.45303   1.000 35.82403 ? 201 EDO A C1   1 
HETATM 2467 O  O1   . EDO B 2 .   ? -4.09343  -22.02448 6.33152   1.000 33.17189 ? 201 EDO A O1   1 
HETATM 2468 C  C2   . EDO B 2 .   ? -3.43057  -24.14595 5.50767   1.000 41.64045 ? 201 EDO A C2   1 
HETATM 2469 O  O2   . EDO B 2 .   ? -3.56896  -24.54480 6.87496   1.000 60.54995 ? 201 EDO A O2   1 
HETATM 2470 H  H11  . EDO B 2 .   ? -3.27394  -22.28549 4.43368   1.000 42.98947 ? 201 EDO A H11  1 
HETATM 2471 H  H12  . EDO B 2 .   ? -2.13190  -22.44783 5.77059   1.000 42.98947 ? 201 EDO A H12  1 
HETATM 2472 H  HO1  . EDO B 2 .   ? -4.70917  -21.48870 5.81297   1.000 39.80691 ? 201 EDO A HO1  1 
HETATM 2473 H  H21  . EDO B 2 .   ? -4.34518  -24.37648 4.95740   1.000 49.96919 ? 201 EDO A H21  1 
HETATM 2474 H  H22  . EDO B 2 .   ? -2.61029  -24.69465 5.04019   1.000 49.96919 ? 201 EDO A H22  1 
HETATM 2475 H  HO2  . EDO B 2 .   ? -3.86556  -25.46436 6.91403   1.000 72.66058 ? 201 EDO A HO2  1 
HETATM 2476 CL CL   . CL  C 3 .   ? 8.28098   -31.83248 7.26474   1.000 26.74174 ? 202 CL  A CL   1 
HETATM 2477 CL CL   . CL  D 3 .   ? 6.19609   -10.57609 -5.25408  1.000 65.50337 ? 203 CL  A CL   1 
HETATM 2478 NA NA   . NA  E 4 .   ? -8.08176  -14.71699 12.91824  1.000 28.05095 ? 204 NA  A NA   1 
HETATM 2479 NA NA   . NA  F 4 .   ? 11.18404  -29.15439 -7.07985  1.000 30.49403 ? 205 NA  A NA   1 
HETATM 2480 O  O    B HOH G 5 .   ? -4.55096  -23.86124 8.89618   0.928 38.69894 ? 301 HOH A O    1 
HETATM 2481 O  O    . HOH G 5 .   ? -1.191    -18.459   23.326    1.000 38.62517 ? 302 HOH A O    1 
HETATM 2482 O  O    . HOH G 5 .   ? 9.40717   -28.52505 11.19218  1.000 52.00981 ? 303 HOH A O    1 
HETATM 2483 O  O    . HOH G 5 .   ? -1.57083  -13.91210 -2.18129  1.000 31.07851 ? 304 HOH A O    1 
HETATM 2484 O  O    . HOH G 5 .   ? -7.55108  -24.91875 0.92296   1.000 37.22910 ? 305 HOH A O    1 
HETATM 2485 O  O    . HOH G 5 .   ? 15.94397  -16.59708 -12.64596 1.000 48.69815 ? 306 HOH A O    1 
HETATM 2486 O  O    . HOH G 5 .   ? -0.41552  -13.11826 17.58818  1.000 56.18321 ? 307 HOH A O    1 
HETATM 2487 O  O    . HOH G 5 .   ? 6.73587   -28.50373 10.46035  1.000 29.49903 ? 308 HOH A O    1 
HETATM 2488 O  O    . HOH G 5 .   ? -12.59381 -25.37185 12.57701  1.000 43.88887 ? 309 HOH A O    1 
HETATM 2489 O  O    A HOH G 5 .   ? -10.61903 -23.24997 10.41089  0.551 37.64424 ? 310 HOH A O    1 
HETATM 2490 O  O    B HOH G 5 .   ? -11.29502 -24.13104 9.11996   0.449 34.53020 ? 310 HOH A O    1 
HETATM 2491 O  O    . HOH G 5 .   ? 0.23754   -12.20787 -2.26490  1.000 32.48356 ? 311 HOH A O    1 
HETATM 2492 O  O    . HOH G 5 .   ? -11.70883 -13.54264 -4.03288  1.000 22.05306 ? 312 HOH A O    1 
HETATM 2493 O  O    . HOH G 5 .   ? -1.81611  -33.95364 -9.14770  1.000 32.39480 ? 313 HOH A O    1 
HETATM 2494 O  O    . HOH G 5 .   ? -7.731    -4.298    5.442     1.000 38.66390 ? 314 HOH A O    1 
HETATM 2495 O  O    . HOH G 5 .   ? -14.09145 -15.13523 7.78102   1.000 21.41310 ? 315 HOH A O    1 
HETATM 2496 O  O    A HOH G 5 .   ? -14.49597 -25.29892 8.23200   0.765 41.83022 ? 316 HOH A O    1 
HETATM 2497 O  O    . HOH G 5 .   ? 20.74111  -19.62108 -21.24519 1.000 61.88976 ? 317 HOH A O    1 
HETATM 2498 O  O    . HOH G 5 .   ? -5.78613  -11.06108 -9.55371  1.000 22.35742 ? 318 HOH A O    1 
HETATM 2499 O  O    . HOH G 5 .   ? 6.85311   -10.96788 -10.90382 1.000 51.41935 ? 319 HOH A O    1 
HETATM 2500 O  O    . HOH G 5 .   ? -4.846    -4.419    2.902     1.000 53.86655 ? 320 HOH A O    1 
HETATM 2501 O  O    . HOH G 5 .   ? 3.12901   -8.61621  0.80726   1.000 33.29317 ? 321 HOH A O    1 
HETATM 2502 O  O    . HOH G 5 .   ? 14.047    -24.788   -14.045   1.000 46.83012 ? 322 HOH A O    1 
HETATM 2503 O  O    . HOH G 5 .   ? -9.18795  -24.33603 4.81983   1.000 46.86049 ? 323 HOH A O    1 
HETATM 2504 O  O    . HOH G 5 .   ? -7.86742  -26.33914 -3.46385  1.000 34.56754 ? 324 HOH A O    1 
HETATM 2505 O  O    . HOH G 5 .   ? 1.61098   -12.44595 -14.58775 1.000 50.46818 ? 325 HOH A O    1 
HETATM 2506 O  O    . HOH G 5 .   ? 14.43109  -32.17999 1.57691   1.000 38.59960 ? 326 HOH A O    1 
HETATM 2507 O  O    . HOH G 5 .   ? -4.19800  -6.25283  -0.36688  1.000 44.40217 ? 327 HOH A O    1 
HETATM 2508 O  O    . HOH G 5 .   ? 14.438    -15.266   -8.248    1.000 51.55672 ? 328 HOH A O    1 
HETATM 2509 O  O    B HOH G 5 .   ? 2.01895   -27.22574 9.23102   0.620 26.51473 ? 329 HOH A O    1 
HETATM 2510 O  O    . HOH G 5 .   ? 4.40997   -9.20002  -8.02792  1.000 53.92074 ? 330 HOH A O    1 
HETATM 2511 O  O    . HOH G 5 .   ? 4.65418   -11.49301 12.95298  1.000 63.82913 ? 331 HOH A O    1 
HETATM 2512 O  O    . HOH G 5 .   ? -3.54707  -7.43308  -8.34010  1.000 35.58920 ? 332 HOH A O    1 
HETATM 2513 O  O    . HOH G 5 .   ? 6.62318   -35.68682 -4.06998  1.000 41.43888 ? 333 HOH A O    1 
HETATM 2514 O  O    . HOH G 5 .   ? -5.33593  -9.42383  15.91784  1.000 49.68106 ? 334 HOH A O    1 
HETATM 2515 O  O    . HOH G 5 .   ? 5.76100   -21.87903 13.64707  1.000 46.98754 ? 335 HOH A O    1 
HETATM 2516 O  O    . HOH G 5 .   ? 2.69993   -32.66580 -9.59917  1.000 33.12018 ? 336 HOH A O    1 
HETATM 2517 O  O    A HOH G 5 .   ? -5.162    -38.239   0.342     0.992 55.60818 ? 337 HOH A O    1 
HETATM 2518 O  O    . HOH G 5 .   ? -3.52509  -19.68184 -13.52410 1.000 39.89860 ? 338 HOH A O    1 
HETATM 2519 O  O    . HOH G 5 .   ? -8.81107  -24.00911 -3.34498  1.000 43.54119 ? 339 HOH A O    1 
HETATM 2520 O  O    . HOH G 5 .   ? 8.25204   -16.11276 8.96699   1.000 51.13385 ? 340 HOH A O    1 
HETATM 2521 O  O    . HOH G 5 .   ? -5.95695  -23.73396 3.00784   1.000 50.69009 ? 341 HOH A O    1 
HETATM 2522 O  O    . HOH G 5 .   ? 6.19598   -33.84501 -2.22615  1.000 34.22114 ? 342 HOH A O    1 
HETATM 2523 O  O    . HOH G 5 .   ? -1.17991  -36.41933 -3.70621  1.000 29.43362 ? 343 HOH A O    1 
HETATM 2524 O  O    . HOH G 5 .   ? -9.41930  -22.87688 -0.04222  1.000 31.08471 ? 344 HOH A O    1 
HETATM 2525 O  O    . HOH G 5 .   ? 0.80708   -7.11483  1.76516   1.000 39.10121 ? 345 HOH A O    1 
HETATM 2526 O  O    . HOH G 5 .   ? 3.13499   -12.17103 6.98706   1.000 38.99817 ? 346 HOH A O    1 
HETATM 2527 O  O    . HOH G 5 .   ? -7.93311  -12.78794 14.30091  1.000 35.11038 ? 347 HOH A O    1 
HETATM 2528 O  O    . HOH G 5 .   ? -14.83400 -14.83400 0.00000   0.5   39.10240 ? 348 HOH A O    1 
HETATM 2529 O  O    . HOH G 5 .   ? -1.77971  -16.61334 0.74952   1.000 20.56597 ? 349 HOH A O    1 
HETATM 2530 O  O    A HOH G 5 .   ? 14.80208  -19.94797 -2.00703  0.570 26.94122 ? 350 HOH A O    1 
HETATM 2531 O  O    B HOH G 5 .   ? 14.15719  -26.15196 -4.61704  0.430 24.75558 ? 350 HOH A O    1 
HETATM 2532 O  O    . HOH G 5 .   ? -17.36605 -8.23099  11.25510  1.000 42.52105 ? 351 HOH A O    1 
HETATM 2533 O  O    . HOH G 5 .   ? -9.24395  -20.86236 -4.98215  1.000 40.24590 ? 352 HOH A O    1 
HETATM 2534 O  O    . HOH G 5 .   ? -0.36995  -38.50916 3.24092   1.000 42.00984 ? 353 HOH A O    1 
HETATM 2535 O  O    A HOH G 5 .   ? 13.95604  -17.72196 5.29296   0.501 33.77065 ? 354 HOH A O    1 
HETATM 2536 O  O    B HOH G 5 .   ? 14.56001  -18.47710 3.81188   0.499 39.66138 ? 354 HOH A O    1 
HETATM 2537 O  O    . HOH G 5 .   ? -9.88365  -13.19514 11.96919  1.000 27.62624 ? 355 HOH A O    1 
HETATM 2538 O  O    . HOH G 5 .   ? 15.15408  -22.06883 2.19000   1.000 49.09999 ? 356 HOH A O    1 
HETATM 2539 O  O    B HOH G 5 .   ? 6.64285   -28.99200 -17.02806 1.000 59.78430 ? 357 HOH A O    1 
HETATM 2540 O  O    . HOH G 5 .   ? 8.89914   -13.00062 -10.52709 1.000 38.40143 ? 358 HOH A O    1 
HETATM 2541 O  O    . HOH G 5 .   ? 14.88811  -24.22109 6.16200   1.000 40.54445 ? 359 HOH A O    1 
HETATM 2542 O  O    . HOH G 5 .   ? 13.878    -24.995   14.194    1.000 47.97324 ? 360 HOH A O    1 
HETATM 2543 O  O    . HOH G 5 .   ? -5.79905  -26.46177 3.69905   1.000 36.33102 ? 361 HOH A O    1 
HETATM 2544 O  O    . HOH G 5 .   ? -8.49880  -17.99336 -8.35156  1.000 29.86688 ? 362 HOH A O    1 
HETATM 2545 O  O    . HOH G 5 .   ? 11.34552  -31.56199 -1.35604  1.000 26.81952 ? 363 HOH A O    1 
HETATM 2546 O  O    . HOH G 5 .   ? 10.67750  -31.84016 4.87120   1.000 30.13054 ? 364 HOH A O    1 
HETATM 2547 O  O    . HOH G 5 .   ? 5.40607   -9.98803  6.23006   1.000 50.09911 ? 365 HOH A O    1 
HETATM 2548 O  O    . HOH G 5 .   ? 17.50312  -22.16597 -14.24396 1.000 52.00245 ? 366 HOH A O    1 
HETATM 2549 O  O    . HOH G 5 .   ? -13.940   -7.775    14.841    1.000 54.58892 ? 367 HOH A O    1 
HETATM 2550 O  O    . HOH G 5 .   ? -4.53498  -33.36398 -9.29589  1.000 27.05556 ? 368 HOH A O    1 
HETATM 2551 O  O    . HOH G 5 .   ? -2.90400  -10.43586 -13.43212 1.000 37.91142 ? 369 HOH A O    1 
HETATM 2552 O  O    . HOH G 5 .   ? -10.364   -6.080    12.239    1.000 34.63574 ? 370 HOH A O    1 
HETATM 2553 O  O    A HOH G 5 .   ? -3.27501  -14.51592 18.06616  0.766 40.63552 ? 371 HOH A O    1 
HETATM 2554 O  O    . HOH G 5 .   ? 5.48506   -19.78802 -16.91130 1.000 36.65954 ? 372 HOH A O    1 
HETATM 2555 O  O    . HOH G 5 .   ? 1.00172   -11.34920 0.25693   1.000 28.27580 ? 373 HOH A O    1 
HETATM 2556 O  O    . HOH G 5 .   ? -11.79869 -12.03995 13.99005  1.000 28.36596 ? 374 HOH A O    1 
HETATM 2557 O  O    A HOH G 5 .   ? 11.44915  -18.68184 -17.34704 0.658 36.50512 ? 375 HOH A O    1 
HETATM 2558 O  O    B HOH G 5 .   ? 11.68415  -17.97592 -13.99098 0.342 29.67997 ? 375 HOH A O    1 
HETATM 2559 O  O    . HOH G 5 .   ? -12.83147 -12.83147 18.99200  0.5   55.73481 ? 376 HOH A O    1 
HETATM 2560 O  O    A HOH G 5 .   ? 3.95699   -37.99904 -10.64991 0.492 29.68550 ? 377 HOH A O    1 
HETATM 2561 O  O    B HOH G 5 .   ? 3.30817   -36.70212 -11.11195 0.508 34.37958 ? 377 HOH A O    1 
HETATM 2562 O  O    . HOH G 5 .   ? -16.59692 -19.12206 -0.79501  1.000 35.52289 ? 378 HOH A O    1 
HETATM 2563 O  O    . HOH G 5 .   ? -1.72422  -5.27602  -4.68407  1.000 38.69559 ? 379 HOH A O    1 
HETATM 2564 O  O    . HOH G 5 .   ? -19.131   -10.322   6.383     1.000 31.94990 ? 380 HOH A O    1 
HETATM 2565 O  O    B HOH G 5 .   ? 3.88994   -13.10864 9.24099   0.932 42.10400 ? 381 HOH A O    1 
HETATM 2566 O  O    A HOH G 5 .   ? 14.26981  -31.28717 -1.36607  0.554 44.17602 ? 382 HOH A O    1 
HETATM 2567 O  O    B HOH G 5 .   ? 14.67900  -33.71292 -0.68793  0.446 29.92287 ? 382 HOH A O    1 
HETATM 2568 O  O    . HOH G 5 .   ? 5.83099   -17.46194 -16.16415 1.000 32.46714 ? 383 HOH A O    1 
HETATM 2569 O  O    . HOH G 5 .   ? 11.18804  -12.45690 2.25690   1.000 59.18639 ? 384 HOH A O    1 
HETATM 2570 O  O    . HOH G 5 .   ? 9.80410   -34.53480 -7.66534  1.000 54.06420 ? 385 HOH A O    1 
HETATM 2571 O  O    A HOH G 5 .   ? -2.53041  -7.44317  13.13021  0.462 40.62603 ? 386 HOH A O    1 
HETATM 2572 O  O    B HOH G 5 .   ? -3.62209  -7.66695  12.67889  0.538 39.93364 ? 386 HOH A O    1 
HETATM 2573 O  O    . HOH G 5 .   ? -7.10613  -24.15096 6.00766   1.000 49.09837 ? 387 HOH A O    1 
HETATM 2574 O  O    . HOH G 5 .   ? 3.40193   -22.71720 -18.17796 1.000 47.44754 ? 388 HOH A O    1 
HETATM 2575 O  O    . HOH G 5 .   ? 10.07027  -29.74405 8.21490   1.000 53.76883 ? 389 HOH A O    1 
HETATM 2576 O  O    . HOH G 5 .   ? -4.62798  -7.63787  -10.43492 1.000 54.08472 ? 390 HOH A O    1 
HETATM 2577 O  O    . HOH G 5 .   ? 9.46507   -33.45602 -3.29206  1.000 41.07522 ? 391 HOH A O    1 
HETATM 2578 O  O    . HOH G 5 .   ? -5.20390  -6.55101  11.98929  1.000 48.75386 ? 392 HOH A O    1 
HETATM 2579 O  O    A HOH G 5 .   ? 17.82806  -20.31804 -2.57498  1.000 49.39182 ? 393 HOH A O    1 
HETATM 2580 O  O    A HOH G 5 .   ? 2.07607   -19.63709 -17.28098 0.542 42.03873 ? 394 HOH A O    1 
HETATM 2581 O  O    B HOH G 5 .   ? 1.43108   -20.81307 -15.77995 0.458 32.11530 ? 394 HOH A O    1 
HETATM 2582 O  O    A HOH G 5 .   ? 12.04973  -12.65500 -8.83510  0.492 37.95868 ? 395 HOH A O    1 
HETATM 2583 O  O    B HOH G 5 .   ? 10.46909  -11.82195 -8.63104  0.508 35.22719 ? 395 HOH A O    1 
HETATM 2584 O  O    B HOH G 5 .   ? 9.52509   -10.97991 -6.07200  0.786 44.94430 ? 396 HOH A O    1 
HETATM 2585 O  O    . HOH G 5 .   ? -2.33846  -24.83109 14.33862  1.000 59.52332 ? 397 HOH A O    1 
HETATM 2586 O  O    . HOH G 5 .   ? -14.39172 -11.54618 16.17233  1.000 56.05001 ? 398 HOH A O    1 
HETATM 2587 O  O    A HOH G 5 .   ? 8.40820   -38.69977 -7.40181  0.648 51.78992 ? 399 HOH A O    1 
HETATM 2588 O  O    B HOH G 5 .   ? 9.34397   -36.66507 -7.15029  0.352 38.24429 ? 399 HOH A O    1 
HETATM 2589 O  O    A HOH G 5 .   ? 3.38024   -28.56998 -15.33279 0.453 42.99724 ? 400 HOH A O    1 
HETATM 2590 O  O    B HOH G 5 .   ? 2.80391   -29.46101 -14.90195 0.547 41.75914 ? 400 HOH A O    1 
HETATM 2591 O  O    . HOH G 5 .   ? -3.96896  -26.29995 13.05594  1.000 58.90604 ? 401 HOH A O    1 
HETATM 2592 O  O    . HOH G 5 .   ? 11.12304  -10.50579 3.51915   1.000 61.53993 ? 402 HOH A O    1 
HETATM 2593 O  O    . HOH G 5 .   ? -2.54710  -4.37688  -7.29001  1.000 63.52206 ? 403 HOH A O    1 
HETATM 2594 O  O    . HOH G 5 .   ? 4.03681   -27.81392 -17.08882 1.000 59.24770 ? 404 HOH A O    1 
HETATM 2595 O  O    . HOH G 5 .   ? -9.91084  -19.44792 -10.53093 1.000 57.08836 ? 405 HOH A O    1 
HETATM 2596 O  O    . HOH G 5 .   ? 13.96108  -27.47407 -7.23507  1.000 48.55847 ? 406 HOH A O    1 
HETATM 2597 O  O    B HOH G 5 .   ? -0.14993  -26.37599 10.72808  0.751 37.60589 ? 407 HOH A O    1 
HETATM 2598 O  O    . HOH G 5 .   ? 0.34158   -23.97390 -15.03604 1.000 49.09809 ? 408 HOH A O    1 
HETATM 2599 O  O    . HOH G 5 .   ? 1.413     -15.282   -17.739   1.000 63.96315 ? 409 HOH A O    1 
HETATM 2600 O  O    . HOH G 5 .   ? 0.54608   -39.64207 0.12306   1.000 52.20494 ? 410 HOH A O    1 
HETATM 2601 O  O    . HOH G 5 .   ? 15.67800  -19.81276 6.39715   1.000 54.64322 ? 411 HOH A O    1 
# 
