data_9FC3
# 
_entry.id   9FC3 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FC3         pdb_00009fc3 10.2210/pdb9fc3/pdb 
WWPDB D_1292137046 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-28 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FC3 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              alke.meents@desy.de 
_pdbx_contact_author.name_first         Alke 
_pdbx_contact_author.name_last          Meents 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6078-4095 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Reinke, P.Y.A.'       1  0000-0002-7354-0839 
'Guenther, S.'         2  ?                   
'Falke, S.'            3  ?                   
'Galchenkova, M.'      4  ?                   
'Rahmani Mashhour, A.' 5  ?                   
'Creon, A.'            6  ?                   
'Lieske, J.'           7  ?                   
'Ewert, W.'            8  ?                   
'Rorigues, A.C.'       9  ?                   
'Thekku Veedu, S.'     10 ?                   
'Fischer, P.'          11 ?                   
'Meents, A.'           12 0000-0001-6078-4095 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'HEN EGG-WHITE Lysozyme incubated at 96% relative humidity' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Reinke, P.Y.A.' 1 0000-0002-7354-0839 
primary 'Meents, A.'     2 0000-0001-6078-4095 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Lysozyme C'   14331.160 1   3.2.1.17 ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL 62.068    1   ?        ? ? ? 
3 non-polymer syn 'CHLORIDE ION' 35.453    2   ?        ? ? ? 
4 non-polymer syn 'SODIUM ION'   22.990    2   ?        ? ? ? 
5 water       nat water          18.015    110 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '1,4-beta-N-acetylmuramidase C,Allergen Gal d IV' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL EDO 
3 'CHLORIDE ION' CL  
4 'SODIUM ION'   NA  
5 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   VAL n 
1 3   PHE n 
1 4   GLY n 
1 5   ARG n 
1 6   CYS n 
1 7   GLU n 
1 8   LEU n 
1 9   ALA n 
1 10  ALA n 
1 11  ALA n 
1 12  MET n 
1 13  LYS n 
1 14  ARG n 
1 15  HIS n 
1 16  GLY n 
1 17  LEU n 
1 18  ASP n 
1 19  ASN n 
1 20  TYR n 
1 21  ARG n 
1 22  GLY n 
1 23  TYR n 
1 24  SER n 
1 25  LEU n 
1 26  GLY n 
1 27  ASN n 
1 28  TRP n 
1 29  VAL n 
1 30  CYS n 
1 31  ALA n 
1 32  ALA n 
1 33  LYS n 
1 34  PHE n 
1 35  GLU n 
1 36  SER n 
1 37  ASN n 
1 38  PHE n 
1 39  ASN n 
1 40  THR n 
1 41  GLN n 
1 42  ALA n 
1 43  THR n 
1 44  ASN n 
1 45  ARG n 
1 46  ASN n 
1 47  THR n 
1 48  ASP n 
1 49  GLY n 
1 50  SER n 
1 51  THR n 
1 52  ASP n 
1 53  TYR n 
1 54  GLY n 
1 55  ILE n 
1 56  LEU n 
1 57  GLN n 
1 58  ILE n 
1 59  ASN n 
1 60  SER n 
1 61  ARG n 
1 62  TRP n 
1 63  TRP n 
1 64  CYS n 
1 65  ASN n 
1 66  ASP n 
1 67  GLY n 
1 68  ARG n 
1 69  THR n 
1 70  PRO n 
1 71  GLY n 
1 72  SER n 
1 73  ARG n 
1 74  ASN n 
1 75  LEU n 
1 76  CYS n 
1 77  ASN n 
1 78  ILE n 
1 79  PRO n 
1 80  CYS n 
1 81  SER n 
1 82  ALA n 
1 83  LEU n 
1 84  LEU n 
1 85  SER n 
1 86  SER n 
1 87  ASP n 
1 88  ILE n 
1 89  THR n 
1 90  ALA n 
1 91  SER n 
1 92  VAL n 
1 93  ASN n 
1 94  CYS n 
1 95  ALA n 
1 96  LYS n 
1 97  LYS n 
1 98  ILE n 
1 99  VAL n 
1 100 SER n 
1 101 ASP n 
1 102 GLY n 
1 103 ASN n 
1 104 GLY n 
1 105 MET n 
1 106 ASN n 
1 107 ALA n 
1 108 TRP n 
1 109 VAL n 
1 110 ALA n 
1 111 TRP n 
1 112 ARG n 
1 113 ASN n 
1 114 ARG n 
1 115 CYS n 
1 116 LYS n 
1 117 GLY n 
1 118 THR n 
1 119 ASP n 
1 120 VAL n 
1 121 GLN n 
1 122 ALA n 
1 123 TRP n 
1 124 ILE n 
1 125 ARG n 
1 126 GLY n 
1 127 CYS n 
1 128 ARG n 
1 129 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   129 
_entity_src_gen.gene_src_common_name               chicken 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 LYZ 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Gallus gallus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9031 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Gallus gallus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9031 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ?                 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'    ?                 'Na 1'           22.990  
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   1   LYS LYS A . n 
A 1 2   VAL 2   2   2   VAL VAL A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   ARG 5   5   5   ARG ARG A . n 
A 1 6   CYS 6   6   6   CYS CYS A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  MET 12  12  12  MET MET A . n 
A 1 13  LYS 13  13  13  LYS LYS A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  HIS 15  15  15  HIS HIS A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ASP 18  18  18  ASP ASP A . n 
A 1 19  ASN 19  19  19  ASN ASN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  TYR 23  23  23  TYR TYR A . n 
A 1 24  SER 24  24  24  SER SER A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  ASN 27  27  27  ASN ASN A . n 
A 1 28  TRP 28  28  28  TRP TRP A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  CYS 30  30  30  CYS CYS A . n 
A 1 31  ALA 31  31  31  ALA ALA A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  PHE 34  34  34  PHE PHE A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  ASN 37  37  37  ASN ASN A . n 
A 1 38  PHE 38  38  38  PHE PHE A . n 
A 1 39  ASN 39  39  39  ASN ASN A . n 
A 1 40  THR 40  40  40  THR THR A . n 
A 1 41  GLN 41  41  41  GLN GLN A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  THR 43  43  43  THR THR A . n 
A 1 44  ASN 44  44  44  ASN ASN A . n 
A 1 45  ARG 45  45  45  ARG ARG A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  THR 47  47  47  THR THR A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  SER 50  50  50  SER SER A . n 
A 1 51  THR 51  51  51  THR THR A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  TYR 53  53  53  TYR TYR A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  ILE 58  58  58  ILE ILE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  TRP 62  62  62  TRP TRP A . n 
A 1 63  TRP 63  63  63  TRP TRP A . n 
A 1 64  CYS 64  64  64  CYS CYS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  ASP 66  66  66  ASP ASP A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  PRO 70  70  70  PRO PRO A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  CYS 76  76  76  CYS CYS A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  PRO 79  79  79  PRO PRO A . n 
A 1 80  CYS 80  80  80  CYS CYS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  SER 85  85  85  SER SER A . n 
A 1 86  SER 86  86  86  SER SER A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  ILE 88  88  88  ILE ILE A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  CYS 94  94  94  CYS CYS A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  ILE 98  98  98  ILE ILE A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 ASN 103 103 103 ASN ASN A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 MET 105 105 105 MET MET A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 ALA 107 107 107 ALA ALA A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 VAL 109 109 109 VAL VAL A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 TRP 111 111 111 TRP TRP A . n 
A 1 112 ARG 112 112 112 ARG ARG A . n 
A 1 113 ASN 113 113 113 ASN ASN A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 CYS 115 115 115 CYS CYS A . n 
A 1 116 LYS 116 116 116 LYS LYS A . n 
A 1 117 GLY 117 117 117 GLY GLY A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 ASP 119 119 119 ASP ASP A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 ALA 122 122 122 ALA ALA A . n 
A 1 123 TRP 123 123 123 TRP TRP A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 CYS 127 127 127 CYS CYS A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NA 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NA 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1   201 207 EDO EDO A . 
C 3 CL  1   202 2   CL  CL  A . 
D 3 CL  1   203 4   CL  CL  A . 
E 4 NA  1   204 1   NA  NA  A . 
F 4 NA  1   205 2   NA  NA  A . 
G 5 HOH 1   301 25  HOH HOH A . 
G 5 HOH 2   302 45  HOH HOH A . 
G 5 HOH 3   303 173 HOH HOH A . 
G 5 HOH 4   304 109 HOH HOH A . 
G 5 HOH 5   305 93  HOH HOH A . 
G 5 HOH 6   306 81  HOH HOH A . 
G 5 HOH 7   307 49  HOH HOH A . 
G 5 HOH 8   308 34  HOH HOH A . 
G 5 HOH 9   309 100 HOH HOH A . 
G 5 HOH 10  310 166 HOH HOH A . 
G 5 HOH 11  311 130 HOH HOH A . 
G 5 HOH 12  312 3   HOH HOH A . 
G 5 HOH 13  313 4   HOH HOH A . 
G 5 HOH 14  314 1   HOH HOH A . 
G 5 HOH 15  315 164 HOH HOH A . 
G 5 HOH 16  316 106 HOH HOH A . 
G 5 HOH 17  317 6   HOH HOH A . 
G 5 HOH 18  318 144 HOH HOH A . 
G 5 HOH 19  319 5   HOH HOH A . 
G 5 HOH 20  320 178 HOH HOH A . 
G 5 HOH 21  321 150 HOH HOH A . 
G 5 HOH 22  322 41  HOH HOH A . 
G 5 HOH 23  323 2   HOH HOH A . 
G 5 HOH 24  324 47  HOH HOH A . 
G 5 HOH 25  325 152 HOH HOH A . 
G 5 HOH 26  326 60  HOH HOH A . 
G 5 HOH 27  327 175 HOH HOH A . 
G 5 HOH 28  328 59  HOH HOH A . 
G 5 HOH 29  329 122 HOH HOH A . 
G 5 HOH 30  330 168 HOH HOH A . 
G 5 HOH 31  331 128 HOH HOH A . 
G 5 HOH 32  332 97  HOH HOH A . 
G 5 HOH 33  333 66  HOH HOH A . 
G 5 HOH 34  334 117 HOH HOH A . 
G 5 HOH 35  335 127 HOH HOH A . 
G 5 HOH 36  336 160 HOH HOH A . 
G 5 HOH 37  337 151 HOH HOH A . 
G 5 HOH 38  338 43  HOH HOH A . 
G 5 HOH 39  339 9   HOH HOH A . 
G 5 HOH 40  340 163 HOH HOH A . 
G 5 HOH 41  341 28  HOH HOH A . 
G 5 HOH 42  342 11  HOH HOH A . 
G 5 HOH 43  343 7   HOH HOH A . 
G 5 HOH 44  344 35  HOH HOH A . 
G 5 HOH 45  345 14  HOH HOH A . 
G 5 HOH 46  346 17  HOH HOH A . 
G 5 HOH 47  347 147 HOH HOH A . 
G 5 HOH 48  348 20  HOH HOH A . 
G 5 HOH 49  349 10  HOH HOH A . 
G 5 HOH 50  350 50  HOH HOH A . 
G 5 HOH 51  351 169 HOH HOH A . 
G 5 HOH 52  352 107 HOH HOH A . 
G 5 HOH 53  353 8   HOH HOH A . 
G 5 HOH 54  354 33  HOH HOH A . 
G 5 HOH 55  355 153 HOH HOH A . 
G 5 HOH 56  356 155 HOH HOH A . 
G 5 HOH 57  357 121 HOH HOH A . 
G 5 HOH 58  358 131 HOH HOH A . 
G 5 HOH 59  359 13  HOH HOH A . 
G 5 HOH 60  360 12  HOH HOH A . 
G 5 HOH 61  361 62  HOH HOH A . 
G 5 HOH 62  362 36  HOH HOH A . 
G 5 HOH 63  363 162 HOH HOH A . 
G 5 HOH 64  364 46  HOH HOH A . 
G 5 HOH 65  365 15  HOH HOH A . 
G 5 HOH 66  366 16  HOH HOH A . 
G 5 HOH 67  367 165 HOH HOH A . 
G 5 HOH 68  368 55  HOH HOH A . 
G 5 HOH 69  369 115 HOH HOH A . 
G 5 HOH 70  370 18  HOH HOH A . 
G 5 HOH 71  371 29  HOH HOH A . 
G 5 HOH 72  372 108 HOH HOH A . 
G 5 HOH 73  373 112 HOH HOH A . 
G 5 HOH 74  374 23  HOH HOH A . 
G 5 HOH 75  375 158 HOH HOH A . 
G 5 HOH 76  376 22  HOH HOH A . 
G 5 HOH 77  377 30  HOH HOH A . 
G 5 HOH 78  378 134 HOH HOH A . 
G 5 HOH 79  379 61  HOH HOH A . 
G 5 HOH 80  380 91  HOH HOH A . 
G 5 HOH 81  381 24  HOH HOH A . 
G 5 HOH 82  382 99  HOH HOH A . 
G 5 HOH 83  383 157 HOH HOH A . 
G 5 HOH 84  384 145 HOH HOH A . 
G 5 HOH 85  385 149 HOH HOH A . 
G 5 HOH 86  386 57  HOH HOH A . 
G 5 HOH 87  387 174 HOH HOH A . 
G 5 HOH 88  388 87  HOH HOH A . 
G 5 HOH 89  389 126 HOH HOH A . 
G 5 HOH 90  390 146 HOH HOH A . 
G 5 HOH 91  391 86  HOH HOH A . 
G 5 HOH 92  392 148 HOH HOH A . 
G 5 HOH 93  393 78  HOH HOH A . 
G 5 HOH 94  394 171 HOH HOH A . 
G 5 HOH 95  395 154 HOH HOH A . 
G 5 HOH 96  396 159 HOH HOH A . 
G 5 HOH 97  397 138 HOH HOH A . 
G 5 HOH 98  398 129 HOH HOH A . 
G 5 HOH 99  399 110 HOH HOH A . 
G 5 HOH 100 400 132 HOH HOH A . 
G 5 HOH 101 401 101 HOH HOH A . 
G 5 HOH 102 402 170 HOH HOH A . 
G 5 HOH 103 403 139 HOH HOH A . 
G 5 HOH 104 404 176 HOH HOH A . 
G 5 HOH 105 405 125 HOH HOH A . 
G 5 HOH 106 406 172 HOH HOH A . 
G 5 HOH 107 407 74  HOH HOH A . 
G 5 HOH 108 408 118 HOH HOH A . 
G 5 HOH 109 409 73  HOH HOH A . 
G 5 HOH 110 410 177 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FC3 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     79.473 
_cell.length_a_esd                 ? 
_cell.length_b                     79.473 
_cell.length_b_esd                 ? 
_cell.length_c                     37.995 
_cell.length_c_esd                 ? 
_cell.volume                       239974.814 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FC3 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FC3 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.09 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.24 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              3.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1M NaCl, 35% (v/v) ethylene glycol, 20% (w/v) PEG4000, 50 mM sodium acetate pH 3.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     298 
_diffrn.ambient_temp_details             'Humidity chamber controlled' 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.7749 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P09 HiPhaX' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.7749 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P09 HiPhaX' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          21.47 
_reflns.entry_id                                       9FC3 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.4 
_reflns.d_resolution_low                               39.74 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24539 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.98 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                25.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.4 
_reflns_shell.d_res_low                                     1.45 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.01 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2389 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.52 
_reflns_shell.pdbx_CC_star                                  0.827 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.71 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FC3 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.40 
_refine.ls_d_res_low                             39.74 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24539 
_refine.ls_number_reflns_R_free                  2035 
_refine.ls_number_reflns_R_work                  22504 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 8.29 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1504 
_refine.ls_R_factor_R_free                       0.1815 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1476 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.2132 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1687 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.40 
_refine_hist.d_res_low                        39.74 
_refine_hist.number_atoms_solvent             110 
_refine_hist.number_atoms_total               1119 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1001 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0087  ? 1304 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9857  ? 1783 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0866  ? 173  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0082  ? 250  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.4791 ? 500  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.40 1.43  . . 134 1456 100.00 . . . . 0.3121 . . . . . . . . . . . 0.3393 
'X-RAY DIFFRACTION' 1.43 1.47  . . 133 1496 99.94  . . . . 0.2536 . . . . . . . . . . . 0.2753 
'X-RAY DIFFRACTION' 1.47 1.51  . . 134 1459 100.00 . . . . 0.2132 . . . . . . . . . . . 0.1951 
'X-RAY DIFFRACTION' 1.51 1.55  . . 130 1457 100.00 . . . . 0.2021 . . . . . . . . . . . 0.2424 
'X-RAY DIFFRACTION' 1.55 1.60  . . 133 1494 100.00 . . . . 0.1883 . . . . . . . . . . . 0.1899 
'X-RAY DIFFRACTION' 1.60 1.66  . . 136 1475 100.00 . . . . 0.1830 . . . . . . . . . . . 0.2102 
'X-RAY DIFFRACTION' 1.66 1.73  . . 131 1496 100.00 . . . . 0.1854 . . . . . . . . . . . 0.1984 
'X-RAY DIFFRACTION' 1.73 1.80  . . 134 1479 100.00 . . . . 0.1721 . . . . . . . . . . . 0.2084 
'X-RAY DIFFRACTION' 1.81 1.90  . . 138 1476 100.00 . . . . 0.1613 . . . . . . . . . . . 0.1684 
'X-RAY DIFFRACTION' 1.90 2.02  . . 133 1498 100.00 . . . . 0.1430 . . . . . . . . . . . 0.1699 
'X-RAY DIFFRACTION' 2.02 2.17  . . 138 1493 100.00 . . . . 0.1408 . . . . . . . . . . . 0.1707 
'X-RAY DIFFRACTION' 2.18 2.39  . . 134 1519 100.00 . . . . 0.1332 . . . . . . . . . . . 0.1579 
'X-RAY DIFFRACTION' 2.39 2.74  . . 140 1519 100.00 . . . . 0.1408 . . . . . . . . . . . 0.1667 
'X-RAY DIFFRACTION' 2.74 3.45  . . 137 1548 100.00 . . . . 0.1360 . . . . . . . . . . . 0.1908 
'X-RAY DIFFRACTION' 3.45 39.74 . . 150 1639 99.89  . . . . 0.1346 . . . . . . . . . . . 0.1756 
# 
_struct.entry_id                     9FC3 
_struct.title                        'HEN EGG-WHITE Lysozyme incubated at 99% relative humidity' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FC3 
_struct_keywords.text            'Hydrolase, relative humidity' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LYSC_CHICK 
_struct_ref.pdbx_db_accession          P00698 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC
SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
;
_struct_ref.pdbx_align_begin           19 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FC3 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 129 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P00698 
_struct_ref_seq.db_align_beg                  19 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  147 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       129 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 720  ? 
1 MORE         -36  ? 
1 'SSA (A^2)'  6520 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLY A 4   ? HIS A 15  ? GLY A 4   HIS A 15  1 ? 12 
HELX_P HELX_P2 AA2 ASN A 19  ? TYR A 23  ? ASN A 19  TYR A 23  5 ? 5  
HELX_P HELX_P3 AA3 SER A 24  ? ASN A 37  ? SER A 24  ASN A 37  1 ? 14 
HELX_P HELX_P4 AA4 PRO A 79  ? SER A 85  ? PRO A 79  SER A 85  5 ? 7  
HELX_P HELX_P5 AA5 ILE A 88  ? SER A 100 ? ILE A 88  SER A 100 1 ? 13 
HELX_P HELX_P6 AA6 ASN A 103 ? ALA A 107 ? ASN A 103 ALA A 107 5 ? 5  
HELX_P HELX_P7 AA7 TRP A 108 ? CYS A 115 ? TRP A 108 CYS A 115 1 ? 8  
HELX_P HELX_P8 AA8 ASP A 119 ? ARG A 125 ? ASP A 119 ARG A 125 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 6  SG ? ? ? 1_555 A CYS 127 SG ? ? A CYS 6   A CYS 127 1_555 ? ? ? ? ? ? ? 1.996 ? ? 
disulf2 disulf ? ? A CYS 30 SG ? ? ? 1_555 A CYS 115 SG ? ? A CYS 30  A CYS 115 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
disulf3 disulf ? ? A CYS 64 SG ? ? ? 1_555 A CYS 80  SG ? ? A CYS 64  A CYS 80  1_555 ? ? ? ? ? ? ? 2.034 ? ? 
disulf4 disulf ? ? A CYS 76 SG ? ? ? 1_555 A CYS 94  SG ? ? A CYS 76  A CYS 94  1_555 ? ? ? ? ? ? ? 2.032 ? ? 
metalc1 metalc ? ? A SER 24 OG ? ? ? 1_555 F NA  .   NA ? ? A SER 24  A NA  205 1_555 ? ? ? ? ? ? ? 2.943 ? ? 
metalc2 metalc ? ? A SER 60 O  A ? ? 1_555 E NA  .   NA A ? A SER 60  A NA  204 1_555 ? ? ? ? ? ? ? 2.394 ? ? 
metalc3 metalc ? ? A CYS 64 O  ? ? ? 1_555 E NA  .   NA A ? A CYS 64  A NA  204 1_555 ? ? ? ? ? ? ? 2.633 ? ? 
metalc4 metalc ? ? A SER 72 OG A ? ? 1_555 E NA  .   NA A ? A SER 72  A NA  204 1_555 ? ? ? ? ? ? ? 2.300 ? ? 
metalc5 metalc ? ? A ARG 73 O  A ? ? 1_555 E NA  .   NA A ? A ARG 73  A NA  204 1_555 ? ? ? ? ? ? ? 2.383 ? ? 
metalc6 metalc ? ? E NA  .  NA A ? ? 1_555 G HOH .   O  ? ? A NA  204 A HOH 353 1_555 ? ? ? ? ? ? ? 2.671 ? ? 
metalc7 metalc ? ? E NA  .  NA A ? ? 1_555 G HOH .   O  A ? A NA  204 A HOH 381 1_555 ? ? ? ? ? ? ? 2.225 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O  A A SER 60 ? A SER 60  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  ? A CYS 64 ? A CYS 64  ? 1_555 74.6  ? 
2  O  A A SER 60 ? A SER 60  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 OG A A SER 72 ? A SER 72  ? 1_555 90.1  ? 
3  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 OG A A SER 72 ? A SER 72  ? 1_555 148.3 ? 
4  O  A A SER 60 ? A SER 60  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 91.6  ? 
5  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 93.0  ? 
6  OG A A SER 72 ? A SER 72  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A A ARG 73 ? A ARG 73  ? 1_555 115.5 ? 
7  O  A A SER 60 ? A SER 60  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 353 ? 1_555 87.5  ? 
8  O  ? A CYS 64 ? A CYS 64  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 353 ? 1_555 75.0  ? 
9  OG A A SER 72 ? A SER 72  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 353 ? 1_555 76.7  ? 
10 O  A A ARG 73 ? A ARG 73  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  ? G HOH .  ? A HOH 353 ? 1_555 167.7 ? 
11 O  A A SER 60 ? A SER 60  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A G HOH .  ? A HOH 381 ? 1_555 169.8 ? 
12 O  ? A CYS 64 ? A CYS 64  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A G HOH .  ? A HOH 381 ? 1_555 103.5 ? 
13 OG A A SER 72 ? A SER 72  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A G HOH .  ? A HOH 381 ? 1_555 86.5  ? 
14 O  A A ARG 73 ? A ARG 73  ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A G HOH .  ? A HOH 381 ? 1_555 98.5  ? 
15 O  ? G HOH .  ? A HOH 353 ? 1_555 NA A E NA . ? A NA 204 ? 1_555 O  A G HOH .  ? A HOH 381 ? 1_555 82.4  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 6  ? CYS A 127 ? CYS A 6  ? 1_555 CYS A 127 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 30 ? CYS A 115 ? CYS A 30 ? 1_555 CYS A 115 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 64 ? CYS A 80  ? CYS A 64 ? 1_555 CYS A 80  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 76 ? CYS A 94  ? CYS A 76 ? 1_555 CYS A 94  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 43 ? ARG A 45 ? THR A 43 ARG A 45 
AA1 2 THR A 51 ? TYR A 53 ? THR A 51 TYR A 53 
AA1 3 ILE A 58 ? ASN A 59 ? ILE A 58 ASN A 59 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN A 44 ? N ASN A 44 O ASP A 52 ? O ASP A 52 
AA1 2 3 N TYR A 53 ? N TYR A 53 O ILE A 58 ? O ILE A 58 
# 
_pdbx_entry_details.entry_id                   9FC3 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    ARG 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     68 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    B 
_pdbx_validate_torsion.phi             -141.77 
_pdbx_validate_torsion.psi             23.01 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 332 ? G HOH . 
2 1 A HOH 367 ? G HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
EDO C1   C  N N 89  
EDO O1   O  N N 90  
EDO C2   C  N N 91  
EDO O2   O  N N 92  
EDO H11  H  N N 93  
EDO H12  H  N N 94  
EDO HO1  H  N N 95  
EDO H21  H  N N 96  
EDO H22  H  N N 97  
EDO HO2  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MET N    N  N N 241 
MET CA   C  N S 242 
MET C    C  N N 243 
MET O    O  N N 244 
MET CB   C  N N 245 
MET CG   C  N N 246 
MET SD   S  N N 247 
MET CE   C  N N 248 
MET OXT  O  N N 249 
MET H    H  N N 250 
MET H2   H  N N 251 
MET HA   H  N N 252 
MET HB2  H  N N 253 
MET HB3  H  N N 254 
MET HG2  H  N N 255 
MET HG3  H  N N 256 
MET HE1  H  N N 257 
MET HE2  H  N N 258 
MET HE3  H  N N 259 
MET HXT  H  N N 260 
NA  NA   NA N N 261 
PHE N    N  N N 262 
PHE CA   C  N S 263 
PHE C    C  N N 264 
PHE O    O  N N 265 
PHE CB   C  N N 266 
PHE CG   C  Y N 267 
PHE CD1  C  Y N 268 
PHE CD2  C  Y N 269 
PHE CE1  C  Y N 270 
PHE CE2  C  Y N 271 
PHE CZ   C  Y N 272 
PHE OXT  O  N N 273 
PHE H    H  N N 274 
PHE H2   H  N N 275 
PHE HA   H  N N 276 
PHE HB2  H  N N 277 
PHE HB3  H  N N 278 
PHE HD1  H  N N 279 
PHE HD2  H  N N 280 
PHE HE1  H  N N 281 
PHE HE2  H  N N 282 
PHE HZ   H  N N 283 
PHE HXT  H  N N 284 
PRO N    N  N N 285 
PRO CA   C  N S 286 
PRO C    C  N N 287 
PRO O    O  N N 288 
PRO CB   C  N N 289 
PRO CG   C  N N 290 
PRO CD   C  N N 291 
PRO OXT  O  N N 292 
PRO H    H  N N 293 
PRO HA   H  N N 294 
PRO HB2  H  N N 295 
PRO HB3  H  N N 296 
PRO HG2  H  N N 297 
PRO HG3  H  N N 298 
PRO HD2  H  N N 299 
PRO HD3  H  N N 300 
PRO HXT  H  N N 301 
SER N    N  N N 302 
SER CA   C  N S 303 
SER C    C  N N 304 
SER O    O  N N 305 
SER CB   C  N N 306 
SER OG   O  N N 307 
SER OXT  O  N N 308 
SER H    H  N N 309 
SER H2   H  N N 310 
SER HA   H  N N 311 
SER HB2  H  N N 312 
SER HB3  H  N N 313 
SER HG   H  N N 314 
SER HXT  H  N N 315 
THR N    N  N N 316 
THR CA   C  N S 317 
THR C    C  N N 318 
THR O    O  N N 319 
THR CB   C  N R 320 
THR OG1  O  N N 321 
THR CG2  C  N N 322 
THR OXT  O  N N 323 
THR H    H  N N 324 
THR H2   H  N N 325 
THR HA   H  N N 326 
THR HB   H  N N 327 
THR HG1  H  N N 328 
THR HG21 H  N N 329 
THR HG22 H  N N 330 
THR HG23 H  N N 331 
THR HXT  H  N N 332 
TRP N    N  N N 333 
TRP CA   C  N S 334 
TRP C    C  N N 335 
TRP O    O  N N 336 
TRP CB   C  N N 337 
TRP CG   C  Y N 338 
TRP CD1  C  Y N 339 
TRP CD2  C  Y N 340 
TRP NE1  N  Y N 341 
TRP CE2  C  Y N 342 
TRP CE3  C  Y N 343 
TRP CZ2  C  Y N 344 
TRP CZ3  C  Y N 345 
TRP CH2  C  Y N 346 
TRP OXT  O  N N 347 
TRP H    H  N N 348 
TRP H2   H  N N 349 
TRP HA   H  N N 350 
TRP HB2  H  N N 351 
TRP HB3  H  N N 352 
TRP HD1  H  N N 353 
TRP HE1  H  N N 354 
TRP HE3  H  N N 355 
TRP HZ2  H  N N 356 
TRP HZ3  H  N N 357 
TRP HH2  H  N N 358 
TRP HXT  H  N N 359 
TYR N    N  N N 360 
TYR CA   C  N S 361 
TYR C    C  N N 362 
TYR O    O  N N 363 
TYR CB   C  N N 364 
TYR CG   C  Y N 365 
TYR CD1  C  Y N 366 
TYR CD2  C  Y N 367 
TYR CE1  C  Y N 368 
TYR CE2  C  Y N 369 
TYR CZ   C  Y N 370 
TYR OH   O  N N 371 
TYR OXT  O  N N 372 
TYR H    H  N N 373 
TYR H2   H  N N 374 
TYR HA   H  N N 375 
TYR HB2  H  N N 376 
TYR HB3  H  N N 377 
TYR HD1  H  N N 378 
TYR HD2  H  N N 379 
TYR HE1  H  N N 380 
TYR HE2  H  N N 381 
TYR HH   H  N N 382 
TYR HXT  H  N N 383 
VAL N    N  N N 384 
VAL CA   C  N S 385 
VAL C    C  N N 386 
VAL O    O  N N 387 
VAL CB   C  N N 388 
VAL CG1  C  N N 389 
VAL CG2  C  N N 390 
VAL OXT  O  N N 391 
VAL H    H  N N 392 
VAL H2   H  N N 393 
VAL HA   H  N N 394 
VAL HB   H  N N 395 
VAL HG11 H  N N 396 
VAL HG12 H  N N 397 
VAL HG13 H  N N 398 
VAL HG21 H  N N 399 
VAL HG22 H  N N 400 
VAL HG23 H  N N 401 
VAL HXT  H  N N 402 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
THR N   CA   sing N N 299 
THR N   H    sing N N 300 
THR N   H2   sing N N 301 
THR CA  C    sing N N 302 
THR CA  CB   sing N N 303 
THR CA  HA   sing N N 304 
THR C   O    doub N N 305 
THR C   OXT  sing N N 306 
THR CB  OG1  sing N N 307 
THR CB  CG2  sing N N 308 
THR CB  HB   sing N N 309 
THR OG1 HG1  sing N N 310 
THR CG2 HG21 sing N N 311 
THR CG2 HG22 sing N N 312 
THR CG2 HG23 sing N N 313 
THR OXT HXT  sing N N 314 
TRP N   CA   sing N N 315 
TRP N   H    sing N N 316 
TRP N   H2   sing N N 317 
TRP CA  C    sing N N 318 
TRP CA  CB   sing N N 319 
TRP CA  HA   sing N N 320 
TRP C   O    doub N N 321 
TRP C   OXT  sing N N 322 
TRP CB  CG   sing N N 323 
TRP CB  HB2  sing N N 324 
TRP CB  HB3  sing N N 325 
TRP CG  CD1  doub Y N 326 
TRP CG  CD2  sing Y N 327 
TRP CD1 NE1  sing Y N 328 
TRP CD1 HD1  sing N N 329 
TRP CD2 CE2  doub Y N 330 
TRP CD2 CE3  sing Y N 331 
TRP NE1 CE2  sing Y N 332 
TRP NE1 HE1  sing N N 333 
TRP CE2 CZ2  sing Y N 334 
TRP CE3 CZ3  doub Y N 335 
TRP CE3 HE3  sing N N 336 
TRP CZ2 CH2  doub Y N 337 
TRP CZ2 HZ2  sing N N 338 
TRP CZ3 CH2  sing Y N 339 
TRP CZ3 HZ3  sing N N 340 
TRP CH2 HH2  sing N N 341 
TRP OXT HXT  sing N N 342 
TYR N   CA   sing N N 343 
TYR N   H    sing N N 344 
TYR N   H2   sing N N 345 
TYR CA  C    sing N N 346 
TYR CA  CB   sing N N 347 
TYR CA  HA   sing N N 348 
TYR C   O    doub N N 349 
TYR C   OXT  sing N N 350 
TYR CB  CG   sing N N 351 
TYR CB  HB2  sing N N 352 
TYR CB  HB3  sing N N 353 
TYR CG  CD1  doub Y N 354 
TYR CG  CD2  sing Y N 355 
TYR CD1 CE1  sing Y N 356 
TYR CD1 HD1  sing N N 357 
TYR CD2 CE2  doub Y N 358 
TYR CD2 HD2  sing N N 359 
TYR CE1 CZ   doub Y N 360 
TYR CE1 HE1  sing N N 361 
TYR CE2 CZ   sing Y N 362 
TYR CE2 HE2  sing N N 363 
TYR CZ  OH   sing N N 364 
TYR OH  HH   sing N N 365 
TYR OXT HXT  sing N N 366 
VAL N   CA   sing N N 367 
VAL N   H    sing N N 368 
VAL N   H2   sing N N 369 
VAL CA  C    sing N N 370 
VAL CA  CB   sing N N 371 
VAL CA  HA   sing N N 372 
VAL C   O    doub N N 373 
VAL C   OXT  sing N N 374 
VAL CB  CG1  sing N N 375 
VAL CB  CG2  sing N N 376 
VAL CB  HB   sing N N 377 
VAL CG1 HG11 sing N N 378 
VAL CG1 HG12 sing N N 379 
VAL CG1 HG13 sing N N 380 
VAL CG2 HG21 sing N N 381 
VAL CG2 HG22 sing N N 382 
VAL CG2 HG23 sing N N 383 
VAL OXT HXT  sing N N 384 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Helmholtz Association' Germany FISCOV 1 
'Helmholtz Association' Germany FRAGX  2 
'Helmholtz Association' Germany HIR3X  3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'intern model of RT lysozyme' 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FC3 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012583 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012583 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.026319 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
NA ? ? 9.38062 1.54875 ? ? 3.38349  72.32734 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    A LYS A 1 1   ? -3.34700  -10.26600 -8.63300  0.460 22.52784 ? 1   LYS A N    1 
ATOM   2    N  N    B LYS A 1 1   ? -3.31200  -10.20600 -8.70800  0.540 22.79584 ? 1   LYS A N    1 
ATOM   3    C  CA   A LYS A 1 1   ? -2.47300  -10.60500 -9.78900  0.460 22.96608 ? 1   LYS A CA   1 
ATOM   4    C  CA   B LYS A 1 1   ? -2.40700  -10.58000 -9.82800  0.540 22.99737 ? 1   LYS A CA   1 
ATOM   5    C  C    A LYS A 1 1   ? -2.54500  -12.10100 -10.00600 0.460 21.82155 ? 1   LYS A C    1 
ATOM   6    C  C    B LYS A 1 1   ? -2.46600  -12.08000 -10.01200 0.540 21.86126 ? 1   LYS A C    1 
ATOM   7    O  O    A LYS A 1 1   ? -2.61500  -12.86500 -9.04400  0.460 21.44656 ? 1   LYS A O    1 
ATOM   8    O  O    B LYS A 1 1   ? -2.44200  -12.82100 -9.02700  0.540 21.85746 ? 1   LYS A O    1 
ATOM   9    C  CB   A LYS A 1 1   ? -1.04100  -10.17700 -9.48300  0.460 24.42591 ? 1   LYS A CB   1 
ATOM   10   C  CB   B LYS A 1 1   ? -0.98400  -10.13500 -9.49300  0.540 24.57490 ? 1   LYS A CB   1 
ATOM   11   C  CG   A LYS A 1 1   ? -0.01100  -10.51900 -10.54900 0.460 27.16412 ? 1   LYS A CG   1 
ATOM   12   C  CG   B LYS A 1 1   ? 0.09900   -10.71100 -10.38900 0.540 27.08543 ? 1   LYS A CG   1 
ATOM   13   C  CD   A LYS A 1 1   ? 1.37300   -10.11700 -10.07200 0.460 29.20463 ? 1   LYS A CD   1 
ATOM   14   C  CD   B LYS A 1 1   ? 1.44800   -10.08800 -10.07600 0.540 29.15463 ? 1   LYS A CD   1 
ATOM   15   C  CE   A LYS A 1 1   ? 2.46400   -10.71400 -10.94400 0.460 33.44899 ? 1   LYS A CE   1 
ATOM   16   C  CE   B LYS A 1 1   ? 2.54900   -10.73700 -10.90200 0.540 33.44872 ? 1   LYS A CE   1 
ATOM   17   N  NZ   A LYS A 1 1   ? 3.74200   -9.97000  -10.78000 0.460 34.48275 ? 1   LYS A NZ   1 
ATOM   18   N  NZ   B LYS A 1 1   ? 2.32900   -10.53700 -12.36100 0.540 35.99054 ? 1   LYS A NZ   1 
ATOM   19   H  H1   A LYS A 1 1   ? -4.16700  -10.58100 -8.77900  0.460 27.03697 ? 1   LYS A H1   1 
ATOM   20   H  H1   B LYS A 1 1   ? -3.86400  -10.88300 -8.53400  0.540 27.35858 ? 1   LYS A H1   1 
ATOM   21   H  H2   A LYS A 1 1   ? -3.01600  -10.63300 -7.89300  0.460 27.03697 ? 1   LYS A H2   1 
ATOM   22   H  H2   B LYS A 1 1   ? -2.82800  -10.02500 -7.98300  0.540 27.35858 ? 1   LYS A H2   1 
ATOM   23   H  H3   A LYS A 1 1   ? -3.38100  -9.38200  -8.53700  0.460 27.03697 ? 1   LYS A H3   1 
ATOM   24   H  H3   B LYS A 1 1   ? -3.78600  -9.48800  -8.93600  0.540 27.35858 ? 1   LYS A H3   1 
ATOM   25   H  HA   A LYS A 1 1   ? -2.75000  -10.14800 -10.59800 0.460 27.56286 ? 1   LYS A HA   1 
ATOM   26   H  HA   B LYS A 1 1   ? -2.66600  -10.14800 -10.65700 0.540 27.60042 ? 1   LYS A HA   1 
ATOM   27   H  HB2  A LYS A 1 1   ? -1.02900  -9.21400  -9.36800  0.460 29.31466 ? 1   LYS A HB2  1 
ATOM   28   H  HB2  B LYS A 1 1   ? -0.93900  -9.16900  -9.56800  0.540 29.49345 ? 1   LYS A HB2  1 
ATOM   29   H  HB3  A LYS A 1 1   ? -0.76200  -10.61300 -8.66200  0.460 29.31466 ? 1   LYS A HB3  1 
ATOM   30   H  HB3  B LYS A 1 1   ? -0.78300  -10.40700 -8.58400  0.540 29.49345 ? 1   LYS A HB3  1 
ATOM   31   H  HG2  A LYS A 1 1   ? -0.01900  -11.47400 -10.71800 0.460 32.60051 ? 1   LYS A HG2  1 
ATOM   32   H  HG2  B LYS A 1 1   ? 0.16100   -11.66800 -10.24600 0.540 32.50608 ? 1   LYS A HG2  1 
ATOM   33   H  HG3  A LYS A 1 1   ? -0.21200  -10.03600 -11.36600 0.460 32.60051 ? 1   LYS A HG3  1 
ATOM   34   H  HG3  B LYS A 1 1   ? -0.11700  -10.52700 -11.31600 0.540 32.50608 ? 1   LYS A HG3  1 
ATOM   35   H  HD2  A LYS A 1 1   ? 1.45400   -9.15100  -10.10200 0.460 35.04912 ? 1   LYS A HD2  1 
ATOM   36   H  HD2  B LYS A 1 1   ? 1.42400   -9.14100  -10.28500 0.540 34.98913 ? 1   LYS A HD2  1 
ATOM   37   H  HD3  A LYS A 1 1   ? 1.50300   -10.43300 -9.16400  0.460 35.04912 ? 1   LYS A HD3  1 
ATOM   38   H  HD3  B LYS A 1 1   ? 1.65300   -10.21500 -9.13600  0.540 34.98913 ? 1   LYS A HD3  1 
ATOM   39   H  HE2  A LYS A 1 1   ? 2.61100   -11.63800 -10.69000 0.460 40.14236 ? 1   LYS A HE2  1 
ATOM   40   H  HE2  B LYS A 1 1   ? 3.40200   -10.34300 -10.66600 0.540 40.14203 ? 1   LYS A HE2  1 
ATOM   41   H  HE3  A LYS A 1 1   ? 2.19600   -10.66400 -11.87500 0.460 40.14236 ? 1   LYS A HE3  1 
ATOM   42   H  HE3  B LYS A 1 1   ? 2.56300   -11.69100 -10.72400 0.540 40.14203 ? 1   LYS A HE3  1 
ATOM   43   H  HZ1  A LYS A 1 1   ? 4.38700   -10.36800 -11.24700 0.460 41.38287 ? 1   LYS A HZ1  1 
ATOM   44   H  HZ1  B LYS A 1 1   ? 2.29700   -9.66700  -12.54700 0.540 43.19222 ? 1   LYS A HZ1  1 
ATOM   45   H  HZ2  A LYS A 1 1   ? 3.64800   -9.13500  -11.07200 0.460 41.38287 ? 1   LYS A HZ2  1 
ATOM   46   H  HZ2  B LYS A 1 1   ? 2.99300   -10.90700 -12.82200 0.540 43.19222 ? 1   LYS A HZ2  1 
ATOM   47   H  HZ3  A LYS A 1 1   ? 3.97600   -9.95200  -9.92200  0.460 41.38287 ? 1   LYS A HZ3  1 
ATOM   48   H  HZ3  B LYS A 1 1   ? 1.56100   -10.91400 -12.60700 0.540 43.19222 ? 1   LYS A HZ3  1 
ATOM   49   N  N    . VAL A 1 2   ? -2.56500  -12.53100 -11.25700 1.000 22.52674 ? 2   VAL A N    1 
ATOM   50   C  CA   . VAL A 1 2   ? -2.46500  -13.94600 -11.59800 1.000 21.09289 ? 2   VAL A CA   1 
ATOM   51   C  C    . VAL A 1 2   ? -1.05800  -14.17700 -12.11400 1.000 23.23308 ? 2   VAL A C    1 
ATOM   52   O  O    . VAL A 1 2   ? -0.63700  -13.56800 -13.11200 1.000 26.69404 ? 2   VAL A O    1 
ATOM   53   C  CB   . VAL A 1 2   ? -3.51500  -14.35800 -12.63100 1.000 22.50901 ? 2   VAL A CB   1 
ATOM   54   C  CG1  . VAL A 1 2   ? -3.41900  -15.82700 -12.93600 1.000 27.51169 ? 2   VAL A CG1  1 
ATOM   55   C  CG2  . VAL A 1 2   ? -4.90300  -14.02900 -12.11100 1.000 23.66791 ? 2   VAL A CG2  1 
ATOM   56   H  H    . VAL A 1 2   ? -2.69300  -12.02700 -11.94200 1.000 27.03566 ? 2   VAL A H    1 
ATOM   57   H  HA   . VAL A 1 2   ? -2.60800  -14.48900 -10.80700 1.000 25.31504 ? 2   VAL A HA   1 
ATOM   58   H  HB   . VAL A 1 2   ? -3.35600  -13.86800 -13.45300 1.000 27.01439 ? 2   VAL A HB   1 
ATOM   59   H  HG11 . VAL A 1 2   ? -4.16800  -16.08300 -13.49600 1.000 33.01760 ? 2   VAL A HG11 1 
ATOM   60   H  HG12 . VAL A 1 2   ? -2.58500  -15.99900 -13.40000 1.000 33.01760 ? 2   VAL A HG12 1 
ATOM   61   H  HG13 . VAL A 1 2   ? -3.44300  -16.32400 -12.10400 1.000 33.01760 ? 2   VAL A HG13 1 
ATOM   62   H  HG21 . VAL A 1 2   ? -5.56100  -14.31400 -12.76400 1.000 28.40506 ? 2   VAL A HG21 1 
ATOM   63   H  HG22 . VAL A 1 2   ? -5.04500  -14.49600 -11.27300 1.000 28.40506 ? 2   VAL A HG22 1 
ATOM   64   H  HG23 . VAL A 1 2   ? -4.96900  -13.07100 -11.97100 1.000 28.40506 ? 2   VAL A HG23 1 
ATOM   65   N  N    . PHE A 1 3   ? -0.28800  -14.97000 -11.38700 1.000 20.22659 ? 3   PHE A N    1 
ATOM   66   C  CA   . PHE A 1 3   ? 1.09400   -15.23300 -11.76400 1.000 20.34567 ? 3   PHE A CA   1 
ATOM   67   C  C    . PHE A 1 3   ? 1.14300   -16.30300 -12.83400 1.000 22.72697 ? 3   PHE A C    1 
ATOM   68   O  O    . PHE A 1 3   ? 0.30600   -17.20300 -12.89200 1.000 22.92203 ? 3   PHE A O    1 
ATOM   69   C  CB   . PHE A 1 3   ? 1.88500   -15.75700 -10.55700 1.000 21.69638 ? 3   PHE A CB   1 
ATOM   70   C  CG   . PHE A 1 3   ? 2.43300   -14.68800 -9.64500  1.000 20.13812 ? 3   PHE A CG   1 
ATOM   71   C  CD1  . PHE A 1 3   ? 1.64200   -14.09900 -8.66200  1.000 22.48992 ? 3   PHE A CD1  1 
ATOM   72   C  CD2  . PHE A 1 3   ? 3.75000   -14.32200 -9.70900  1.000 23.79341 ? 3   PHE A CD2  1 
ATOM   73   C  CE1  . PHE A 1 3   ? 2.14800   -13.17000 -7.81900  1.000 26.83502 ? 3   PHE A CE1  1 
ATOM   74   C  CE2  . PHE A 1 3   ? 4.25800   -13.37700 -8.86700  1.000 25.31345 ? 3   PHE A CE2  1 
ATOM   75   C  CZ   . PHE A 1 3   ? 3.45400   -12.79700 -7.91200  1.000 28.39249 ? 3   PHE A CZ   1 
ATOM   76   H  H    . PHE A 1 3   ? -0.54100  -15.36900 -10.66800 1.000 24.27548 ? 3   PHE A H    1 
ATOM   77   H  HA   . PHE A 1 3   ? 1.49600   -14.41300 -12.09000 1.000 24.41837 ? 3   PHE A HA   1 
ATOM   78   H  HB2  . PHE A 1 3   ? 1.30000   -16.32000 -10.02700 1.000 26.03923 ? 3   PHE A HB2  1 
ATOM   79   H  HB3  . PHE A 1 3   ? 2.63700   -16.27500 -10.88300 1.000 26.03923 ? 3   PHE A HB3  1 
ATOM   80   H  HD1  . PHE A 1 3   ? 0.75000   -14.34900 -8.58400  1.000 26.99148 ? 3   PHE A HD1  1 
ATOM   81   H  HD2  . PHE A 1 3   ? 4.30700   -14.72400 -10.33600 1.000 28.55566 ? 3   PHE A HD2  1 
ATOM   82   H  HE1  . PHE A 1 3   ? 1.60100   -12.78400 -7.17300  1.000 32.20560 ? 3   PHE A HE1  1 
ATOM   83   H  HE2  . PHE A 1 3   ? 5.15000   -13.12400 -8.93800  1.000 30.37971 ? 3   PHE A HE2  1 
ATOM   84   H  HZ   . PHE A 1 3   ? 3.80000   -12.15500 -7.33500  1.000 34.07455 ? 3   PHE A HZ   1 
ATOM   85   N  N    . GLY A 1 4   ? 2.18200   -16.20600 -13.69000 1.000 24.32724 ? 4   GLY A N    1 
ATOM   86   C  CA   . GLY A 1 4   ? 2.60500   -17.35700 -14.44200 1.000 25.21093 ? 4   GLY A CA   1 
ATOM   87   C  C    . GLY A 1 4   ? 3.39800   -18.31000 -13.57300 1.000 20.85439 ? 4   GLY A C    1 
ATOM   88   O  O    . GLY A 1 4   ? 3.98100   -17.93300 -12.56300 1.000 21.80776 ? 4   GLY A O    1 
ATOM   89   H  H    . GLY A 1 4   ? 2.63600   -15.49000 -13.83700 1.000 29.19626 ? 4   GLY A H    1 
ATOM   90   H  HA2  . GLY A 1 4   ? 1.82800   -17.82400 -14.78800 1.000 30.25669 ? 4   GLY A HA2  1 
ATOM   91   H  HA3  . GLY A 1 4   ? 3.16100   -17.07600 -15.18500 1.000 30.25669 ? 4   GLY A HA3  1 
ATOM   92   N  N    . ARG A 1 5   ? 3.45300   -19.55900 -14.01300 1.000 23.79567 ? 5   ARG A N    1 
ATOM   93   C  CA   . ARG A 1 5   ? 4.13800   -20.59900 -13.25600 1.000 22.70571 ? 5   ARG A CA   1 
ATOM   94   C  C    . ARG A 1 5   ? 5.59700   -20.24100 -12.97000 1.000 22.61306 ? 5   ARG A C    1 
ATOM   95   O  O    . ARG A 1 5   ? 6.05900   -20.30200 -11.82300 1.000 21.70536 ? 5   ARG A O    1 
ATOM   96   C  CB   . ARG A 1 5   ? 4.02500   -21.88700 -14.07600 1.000 28.15519 ? 5   ARG A CB   1 
ATOM   97   C  CG   . ARG A 1 5   ? 4.78000   -23.04500 -13.55200 1.000 28.47504 ? 5   ARG A CG   1 
ATOM   98   C  CD   . ARG A 1 5   ? 4.50800   -24.28200 -14.41300 1.000 26.28114 ? 5   ARG A CD   1 
ATOM   99   N  NE   . ARG A 1 5   ? 5.09300   -24.22500 -15.74800 1.000 32.97334 ? 5   ARG A NE   1 
ATOM   100  C  CZ   . ARG A 1 5   ? 6.32700   -24.62000 -16.04000 1.000 31.92736 ? 5   ARG A CZ   1 
ATOM   101  N  NH1  . ARG A 1 5   ? 7.14800   -25.06800 -15.10900 1.000 31.22464 ? 5   ARG A NH1  1 
ATOM   102  N  NH2  . ARG A 1 5   ? 6.75300   -24.54800 -17.30200 1.000 37.43115 ? 5   ARG A NH2  1 
ATOM   103  H  H    . ARG A 1 5   ? 3.10300   -19.83400 -14.74900 1.000 28.55837 ? 5   ARG A H    1 
ATOM   104  H  HA   . ARG A 1 5   ? 3.72300   -20.71800 -12.38700 1.000 27.25042 ? 5   ARG A HA   1 
ATOM   105  H  HB2  . ARG A 1 5   ? 3.09000   -22.14400 -14.11100 1.000 33.78979 ? 5   ARG A HB2  1 
ATOM   106  H  HB3  . ARG A 1 5   ? 4.35400   -21.70800 -14.97100 1.000 33.78979 ? 5   ARG A HB3  1 
ATOM   107  H  HG2  . ARG A 1 5   ? 5.73100   -22.85200 -13.57600 1.000 34.17362 ? 5   ARG A HG2  1 
ATOM   108  H  HG3  . ARG A 1 5   ? 4.50200   -23.23200 -12.64200 1.000 34.17362 ? 5   ARG A HG3  1 
ATOM   109  H  HD2  . ARG A 1 5   ? 4.87600   -25.05900 -13.96400 1.000 31.54094 ? 5   ARG A HD2  1 
ATOM   110  H  HD3  . ARG A 1 5   ? 3.54900   -24.38200 -14.51700 1.000 31.54094 ? 5   ARG A HD3  1 
ATOM   111  H  HE   . ARG A 1 5   ? 4.60700   -23.91700 -16.38700 1.000 39.57158 ? 5   ARG A HE   1 
ATOM   112  H  HH11 . ARG A 1 5   ? 6.88800   -25.11000 -14.29100 1.000 37.47313 ? 5   ARG A HH11 1 
ATOM   113  H  HH12 . ARG A 1 5   ? 7.94300   -25.31800 -15.32100 1.000 37.47313 ? 5   ARG A HH12 1 
ATOM   114  H  HH21 . ARG A 1 5   ? 6.23000   -24.24900 -17.91600 1.000 44.92095 ? 5   ARG A HH21 1 
ATOM   115  H  HH22 . ARG A 1 5   ? 7.55000   -24.80100 -17.50200 1.000 44.92095 ? 5   ARG A HH22 1 
ATOM   116  N  N    . CYS A 1 6   ? 6.37700   -19.92600 -14.01600 1.000 23.58287 ? 6   CYS A N    1 
ATOM   117  C  CA   . CYS A 1 6   ? 7.78700   -19.65500 -13.77100 1.000 24.95592 ? 6   CYS A CA   1 
ATOM   118  C  C    . CYS A 1 6   ? 7.99900   -18.33200 -13.05800 1.000 22.27555 ? 6   CYS A C    1 
ATOM   119  O  O    . CYS A 1 6   ? 8.95100   -18.19300 -12.29000 1.000 23.37125 ? 6   CYS A O    1 
ATOM   120  C  CB   . CYS A 1 6   ? 8.58300   -19.68800 -15.08900 1.000 24.96979 ? 6   CYS A CB   1 
ATOM   121  S  SG   . CYS A 1 6   ? 8.63500   -21.32000 -15.85300 1.000 26.89789 ? 6   CYS A SG   1 
ATOM   122  H  H    . CYS A 1 6   ? 6.12100   -19.86900 -14.83500 1.000 28.30301 ? 6   CYS A H    1 
ATOM   123  H  HA   . CYS A 1 6   ? 8.13200   -20.35800 -13.19900 1.000 29.95067 ? 6   CYS A HA   1 
ATOM   124  H  HB2  . CYS A 1 6   ? 8.17100   -19.07700 -15.71900 1.000 29.96732 ? 6   CYS A HB2  1 
ATOM   125  H  HB3  . CYS A 1 6   ? 9.49600   -19.41400 -14.90900 1.000 29.96732 ? 6   CYS A HB3  1 
ATOM   126  N  N    . GLU A 1 7   ? 7.13200   -17.34900 -13.29600 1.000 22.08287 ? 7   GLU A N    1 
ATOM   127  C  CA   . GLU A 1 7   ? 7.22800   -16.08400 -12.59600 1.000 22.38701 ? 7   GLU A CA   1 
ATOM   128  C  C    . GLU A 1 7   ? 7.04200   -16.28300 -11.10300 1.000 20.09918 ? 7   GLU A C    1 
ATOM   129  O  O    . GLU A 1 7   ? 7.75200   -15.69400 -10.28800 1.000 23.86578 ? 7   GLU A O    1 
ATOM   130  C  CB   . GLU A 1 7   ? 6.15000   -15.14500 -13.12500 1.000 26.58291 ? 7   GLU A CB   1 
ATOM   131  C  CG   . GLU A 1 7   ? 6.12000   -13.79100 -12.50400 1.000 26.01738 ? 7   GLU A CG   1 
ATOM   132  C  CD   . GLU A 1 7   ? 4.91800   -12.97900 -12.95700 1.000 29.11375 ? 7   GLU A CD   1 
ATOM   133  O  OE1  . GLU A 1 7   ? 3.92800   -13.56200 -13.47800 1.000 31.94409 ? 7   GLU A OE1  1 
ATOM   134  O  OE2  . GLU A 1 7   ? 4.98200   -11.74000 -12.79300 1.000 34.14504 ? 7   GLU A OE2  1 
ATOM   135  H  H    . GLU A 1 7   ? 6.48300   -17.39400 -13.85800 1.000 26.50301 ? 7   GLU A H    1 
ATOM   136  H  HA   . GLU A 1 7   ? 8.10100   -15.69000 -12.75000 1.000 26.86798 ? 7   GLU A HA   1 
ATOM   137  H  HB2  . GLU A 1 7   ? 6.29100   -15.02300 -14.07700 1.000 31.90306 ? 7   GLU A HB2  1 
ATOM   138  H  HB3  . GLU A 1 7   ? 5.28500   -15.55500 -12.96800 1.000 31.90306 ? 7   GLU A HB3  1 
ATOM   139  H  HG2  . GLU A 1 7   ? 6.07500   -13.88500 -11.53900 1.000 31.22443 ? 7   GLU A HG2  1 
ATOM   140  H  HG3  . GLU A 1 7   ? 6.92300   -13.30900 -12.75400 1.000 31.22443 ? 7   GLU A HG3  1 
ATOM   141  N  N    . LEU A 1 8   ? 6.08000   -17.13300 -10.72800 1.000 21.64212 ? 8   LEU A N    1 
ATOM   142  C  CA   . LEU A 1 8   ? 5.86900   -17.39200 -9.30900  1.000 21.65017 ? 8   LEU A CA   1 
ATOM   143  C  C    . LEU A 1 8   ? 7.02400   -18.17200 -8.70800  1.000 18.50413 ? 8   LEU A C    1 
ATOM   144  O  O    . LEU A 1 8   ? 7.47200   -17.87100 -7.59100  1.000 20.41340 ? 8   LEU A O    1 
ATOM   145  C  CB   . LEU A 1 8   ? 4.53900   -18.12800 -9.13700  1.000 21.64077 ? 8   LEU A CB   1 
ATOM   146  C  CG   . LEU A 1 8   ? 4.25700   -18.46400 -7.67900  1.000 19.95825 ? 8   LEU A CG   1 
ATOM   147  C  CD1  . LEU A 1 8   ? 4.04400   -17.20000 -6.88400  1.000 24.14960 ? 8   LEU A CD1  1 
ATOM   148  C  CD2  . LEU A 1 8   ? 3.03300   -19.35300 -7.60800  1.000 23.13181 ? 8   LEU A CD2  1 
ATOM   149  H  H    . LEU A 1 8   ? 5.55500   -17.55700 -11.26100 1.000 25.97412 ? 8   LEU A H    1 
ATOM   150  H  HA   . LEU A 1 8   ? 5.81800   -16.55300 -8.82300  1.000 25.98377 ? 8   LEU A HA   1 
ATOM   151  H  HB2  . LEU A 1 8   ? 3.81900   -17.56500 -9.46400  1.000 25.97249 ? 8   LEU A HB2  1 
ATOM   152  H  HB3  . LEU A 1 8   ? 4.56700   -18.95600 -9.64100  1.000 25.97249 ? 8   LEU A HB3  1 
ATOM   153  H  HG   . LEU A 1 8   ? 5.01100   -18.93400 -7.29000  1.000 23.95347 ? 8   LEU A HG   1 
ATOM   154  H  HD11 . LEU A 1 8   ? 3.65800   -17.42900 -6.02400  1.000 28.98309 ? 8   LEU A HD11 1 
ATOM   155  H  HD12 . LEU A 1 8   ? 4.89800   -16.75900 -6.75700  1.000 28.98309 ? 8   LEU A HD12 1 
ATOM   156  H  HD13 . LEU A 1 8   ? 3.44000   -16.61800 -7.37200  1.000 28.98309 ? 8   LEU A HD13 1 
ATOM   157  H  HD21 . LEU A 1 8   ? 2.90800   -19.64500 -6.69200  1.000 27.76174 ? 8   LEU A HD21 1 
ATOM   158  H  HD22 . LEU A 1 8   ? 2.25800   -18.84800 -7.90200  1.000 27.76174 ? 8   LEU A HD22 1 
ATOM   159  H  HD23 . LEU A 1 8   ? 3.16600   -20.12000 -8.18500  1.000 27.76174 ? 8   LEU A HD23 1 
ATOM   160  N  N    . ALA A 1 9   ? 7.52900   -19.16900 -9.43000  1.000 19.50161 ? 9   ALA A N    1 
ATOM   161  C  CA   . ALA A 1 9   ? 8.67300   -19.90900 -8.93800  1.000 20.33633 ? 9   ALA A CA   1 
ATOM   162  C  C    . ALA A 1 9   ? 9.83400   -18.97600 -8.64400  1.000 20.04828 ? 9   ALA A C    1 
ATOM   163  O  O    . ALA A 1 9   ? 10.46300  -19.09000 -7.59700  1.000 21.99749 ? 9   ALA A O    1 
ATOM   164  C  CB   . ALA A 1 9   ? 9.07700   -20.96100 -9.96900  1.000 21.91479 ? 9   ALA A CB   1 
ATOM   165  H  H    . ALA A 1 9   ? 7.23100   -19.42800 -10.19400 1.000 23.40550 ? 9   ALA A H    1 
ATOM   166  H  HA   . ALA A 1 9   ? 8.43500   -20.36200 -8.11400  1.000 24.40717 ? 9   ALA A HA   1 
ATOM   167  H  HB1  . ALA A 1 9   ? 9.84800   -21.44700 -9.63900  1.000 26.30132 ? 9   ALA A HB1  1 
ATOM   168  H  HB2  . ALA A 1 9   ? 8.33500   -21.57000 -10.10500 1.000 26.30132 ? 9   ALA A HB2  1 
ATOM   169  H  HB3  . ALA A 1 9   ? 9.29800   -20.51700 -10.80300 1.000 26.30132 ? 9   ALA A HB3  1 
ATOM   170  N  N    . ALA A 1 10  ? 10.12300  -18.03800 -9.56000  1.000 22.57524 ? 10  ALA A N    1 
ATOM   171  C  CA   . ALA A 1 10  ? 11.23800  -17.12900 -9.32600  1.000 24.14487 ? 10  ALA A CA   1 
ATOM   172  C  C    . ALA A 1 10  ? 10.98100  -16.23200 -8.12500  1.000 22.00376 ? 10  ALA A C    1 
ATOM   173  O  O    . ALA A 1 10  ? 11.88600  -15.97800 -7.32300  1.000 25.52711 ? 10  ALA A O    1 
ATOM   174  C  CB   . ALA A 1 10  ? 11.49200  -16.30100 -10.59000 1.000 27.46579 ? 10  ALA A CB   1 
ATOM   175  H  H    . ALA A 1 10  ? 9.70000   -17.91700 -10.29800 1.000 27.09386 ? 10  ALA A H    1 
ATOM   176  H  HA   . ALA A 1 10  ? 12.03800  -17.64300 -9.13400  1.000 28.97742 ? 10  ALA A HA   1 
ATOM   177  H  HB1  . ALA A 1 10  ? 12.24300  -15.70700 -10.43300 1.000 32.96251 ? 10  ALA A HB1  1 
ATOM   178  H  HB2  . ALA A 1 10  ? 11.69400  -16.90100 -11.32500 1.000 32.96251 ? 10  ALA A HB2  1 
ATOM   179  H  HB3  . ALA A 1 10  ? 10.69800  -15.78300 -10.79400 1.000 32.96251 ? 10  ALA A HB3  1 
ATOM   180  N  N    . ALA A 1 11  ? 9.74300   -15.75300 -7.97200  1.000 22.39608 ? 11  ALA A N    1 
ATOM   181  C  CA   . ALA A 1 11  ? 9.42600   -14.91400 -6.83000  1.000 21.64666 ? 11  ALA A CA   1 
ATOM   182  C  C    . ALA A 1 11  ? 9.55800   -15.69000 -5.53100  1.000 23.15042 ? 11  ALA A C    1 
ATOM   183  O  O    . ALA A 1 11  ? 10.08000  -15.17800 -4.53500  1.000 23.77285 ? 11  ALA A O    1 
ATOM   184  C  CB   . ALA A 1 11  ? 8.02700   -14.33000 -6.95600  1.000 25.96898 ? 11  ALA A CB   1 
ATOM   185  H  H    . ALA A 1 11  ? 9.08600   -15.90000 -8.50700  1.000 26.87887 ? 11  ALA A H    1 
ATOM   186  H  HA   . ALA A 1 11  ? 10.05200  -14.17300 -6.81400  1.000 25.97956 ? 11  ALA A HA   1 
ATOM   187  H  HB1  . ALA A 1 11  ? 7.81300   -13.84300 -6.14500  1.000 31.16634 ? 11  ALA A HB1  1 
ATOM   188  H  HB2  . ALA A 1 11  ? 8.00200   -13.73000 -7.71800  1.000 31.16634 ? 11  ALA A HB2  1 
ATOM   189  H  HB3  . ALA A 1 11  ? 7.39300   -15.05300 -7.08400  1.000 31.16634 ? 11  ALA A HB3  1 
ATOM   190  N  N    . MET A 1 12  ? 9.11500   -16.95200 -5.52500  1.000 21.83353 ? 12  MET A N    1 
ATOM   191  C  CA   . MET A 1 12  ? 9.23900   -17.72200 -4.29200  1.000 21.06473 ? 12  MET A CA   1 
ATOM   192  C  C    . MET A 1 12  ? 10.68700  -18.03700 -3.95400  1.000 20.49283 ? 12  MET A C    1 
ATOM   193  O  O    . MET A 1 12  ? 11.05600  -18.07000 -2.77600  1.000 25.09736 ? 12  MET A O    1 
ATOM   194  C  CB   . MET A 1 12  ? 8.35200   -18.97600 -4.22000  1.000 21.98688 ? 12  MET A CB   1 
ATOM   195  C  CG   . MET A 1 12  ? 6.86900   -18.75900 -4.43800  1.000 19.14664 ? 12  MET A CG   1 
ATOM   196  S  SD   . MET A 1 12  ? 6.03200   -20.35400 -4.68100  1.000 21.50953 ? 12  MET A SD   1 
ATOM   197  C  CE   . MET A 1 12  ? 4.55000   -20.14800 -3.78400  1.000 24.91998 ? 12  MET A CE   1 
ATOM   198  H  H    . MET A 1 12  ? 8.75700   -17.36200 -6.19100  1.000 26.20380 ? 12  MET A H    1 
ATOM   199  H  HA   . MET A 1 12  ? 8.87000   -17.14800 -3.60300  1.000 25.28125 ? 12  MET A HA   1 
ATOM   200  H  HB2  . MET A 1 12  ? 8.65200   -19.59800 -4.90100  1.000 26.38783 ? 12  MET A HB2  1 
ATOM   201  H  HB3  . MET A 1 12  ? 8.45600   -19.37100 -3.34100  1.000 26.38783 ? 12  MET A HB3  1 
ATOM   202  H  HG2  . MET A 1 12  ? 6.48600   -18.32200 -3.66100  1.000 22.97953 ? 12  MET A HG2  1 
ATOM   203  H  HG3  . MET A 1 12  ? 6.73100   -18.21200 -5.22700  1.000 22.97953 ? 12  MET A HG3  1 
ATOM   204  H  HE1  . MET A 1 12  ? 4.01000   -20.94900 -3.87800  1.000 29.90755 ? 12  MET A HE1  1 
ATOM   205  H  HE2  . MET A 1 12  ? 4.76500   -20.00100 -2.85000  1.000 29.90755 ? 12  MET A HE2  1 
ATOM   206  H  HE3  . MET A 1 12  ? 4.07100   -19.38300 -4.13800  1.000 29.90755 ? 12  MET A HE3  1 
ATOM   207  N  N    A LYS A 1 13  ? 11.53400  -18.23400 -4.96400  0.500 22.34058 ? 13  LYS A N    1 
ATOM   208  N  N    B LYS A 1 13  ? 11.50000  -18.30700 -4.98700  0.500 22.44148 ? 13  LYS A N    1 
ATOM   209  C  CA   A LYS A 1 13  ? 12.96000  -18.40200 -4.70500  0.500 22.91777 ? 13  LYS A CA   1 
ATOM   210  C  CA   B LYS A 1 13  ? 12.90900  -18.63300 -4.79700  0.500 23.03860 ? 13  LYS A CA   1 
ATOM   211  C  C    A LYS A 1 13  ? 13.54000  -17.13500 -4.10000  0.500 24.52665 ? 13  LYS A C    1 
ATOM   212  C  C    B LYS A 1 13  ? 13.64900  -17.46800 -4.17500  0.500 21.36513 ? 13  LYS A C    1 
ATOM   213  O  O    A LYS A 1 13  ? 14.22400  -17.17100 -3.06700  0.500 25.12815 ? 13  LYS A O    1 
ATOM   214  O  O    B LYS A 1 13  ? 14.49100  -17.66100 -3.29200  0.500 25.07815 ? 13  LYS A O    1 
ATOM   215  C  CB   A LYS A 1 13  ? 13.67600  -18.72300 -6.01400  0.500 28.03360 ? 13  LYS A CB   1 
ATOM   216  C  CB   B LYS A 1 13  ? 13.54600  -18.96800 -6.14700  0.500 25.11162 ? 13  LYS A CB   1 
ATOM   217  C  CG   A LYS A 1 13  ? 15.12100  -19.18900 -5.82300  0.500 29.30056 ? 13  LYS A CG   1 
ATOM   218  C  CG   B LYS A 1 13  ? 15.05200  -19.30300 -6.07300  0.500 30.24160 ? 13  LYS A CG   1 
ATOM   219  C  CD   A LYS A 1 13  ? 15.62300  -19.99000 -7.02100  0.500 34.95945 ? 13  LYS A CD   1 
ATOM   220  C  CD   B LYS A 1 13  ? 15.54600  -19.98700 -7.35100  0.500 37.58149 ? 13  LYS A CD   1 
ATOM   221  C  CE   A LYS A 1 13  ? 17.14800  -20.00300 -7.11000  0.500 44.74309 ? 13  LYS A CE   1 
ATOM   222  C  CE   B LYS A 1 13  ? 17.06300  -20.21700 -7.36400  0.500 44.86417 ? 13  LYS A CE   1 
ATOM   223  N  NZ   A LYS A 1 13  ? 17.78400  -20.52400 -5.87000  0.500 46.06331 ? 13  LYS A NZ   1 
ATOM   224  N  NZ   B LYS A 1 13  ? 17.42000  -21.60300 -7.79700  0.500 47.32962 ? 13  LYS A NZ   1 
ATOM   225  H  H    A LYS A 1 13  ? 11.31100  -18.27400 -5.79300  0.500 26.81226 ? 13  LYS A H    1 
ATOM   226  H  H    B LYS A 1 13  ? 11.25300  -18.30700 -5.81000  0.500 26.93334 ? 13  LYS A H    1 
ATOM   227  H  HA   A LYS A 1 13  ? 13.09200  -19.13700 -4.08600  0.500 27.50489 ? 13  LYS A HA   1 
ATOM   228  H  HA   B LYS A 1 13  ? 12.97800  -19.40400 -4.21300  0.500 27.64989 ? 13  LYS A HA   1 
ATOM   229  H  HB2  A LYS A 1 13  ? 13.19300  -19.43100 -6.46900  0.500 33.64389 ? 13  LYS A HB2  1 
ATOM   230  H  HB2  B LYS A 1 13  ? 13.09200  -19.73900 -6.52100  0.500 30.13751 ? 13  LYS A HB2  1 
ATOM   231  H  HB3  A LYS A 1 13  ? 13.69100  -17.92500 -6.56600  0.500 33.64389 ? 13  LYS A HB3  1 
ATOM   232  H  HB3  B LYS A 1 13  ? 13.44400  -18.20400 -6.73600  0.500 30.13751 ? 13  LYS A HB3  1 
ATOM   233  H  HG2  A LYS A 1 13  ? 15.69500  -18.41500 -5.71400  0.500 35.16424 ? 13  LYS A HG2  1 
ATOM   234  H  HG2  B LYS A 1 13  ? 15.55700  -18.48300 -5.95300  0.500 36.29348 ? 13  LYS A HG2  1 
ATOM   235  H  HG3  A LYS A 1 13  ? 15.17400  -19.75500 -5.03700  0.500 35.16424 ? 13  LYS A HG3  1 
ATOM   236  H  HG3  B LYS A 1 13  ? 15.21000  -19.90200 -5.32700  0.500 36.29348 ? 13  LYS A HG3  1 
ATOM   237  H  HD2  A LYS A 1 13  ? 15.31800  -20.90700 -6.94200  0.500 41.95490 ? 13  LYS A HD2  1 
ATOM   238  H  HD2  B LYS A 1 13  ? 15.11300  -20.85100 -7.43300  0.500 45.10136 ? 13  LYS A HD2  1 
ATOM   239  H  HD3  A LYS A 1 13  ? 15.27700  -19.59500 -7.83700  0.500 41.95490 ? 13  LYS A HD3  1 
ATOM   240  H  HD3  B LYS A 1 13  ? 15.32200  -19.43000 -8.11300  0.500 45.10136 ? 13  LYS A HD3  1 
ATOM   241  H  HE2  A LYS A 1 13  ? 17.41800  -20.57000 -7.84900  0.500 53.69528 ? 13  LYS A HE2  1 
ATOM   242  H  HE2  B LYS A 1 13  ? 17.47500  -19.59200 -7.98000  0.500 53.84058 ? 13  LYS A HE2  1 
ATOM   243  H  HE3  A LYS A 1 13  ? 17.46500  -19.09800 -7.25400  0.500 53.69528 ? 13  LYS A HE3  1 
ATOM   244  H  HE3  B LYS A 1 13  ? 17.41400  -20.08000 -6.47000  0.500 53.84058 ? 13  LYS A HE3  1 
ATOM   245  H  HZ1  A LYS A 1 13  ? 18.63700  -20.72500 -6.02600  0.500 55.27955 ? 13  LYS A HZ1  1 
ATOM   246  H  HZ1  B LYS A 1 13  ? 18.30400  -21.69600 -7.82100  0.500 56.79911 ? 13  LYS A HZ1  1 
ATOM   247  H  HZ2  A LYS A 1 13  ? 17.74500  -19.91100 -5.22600  0.500 55.27955 ? 13  LYS A HZ2  1 
ATOM   248  H  HZ2  B LYS A 1 13  ? 17.08200  -22.19700 -7.22700  0.500 56.79911 ? 13  LYS A HZ2  1 
ATOM   249  H  HZ3  A LYS A 1 13  ? 17.36000  -21.25700 -5.59500  0.500 55.27955 ? 13  LYS A HZ3  1 
ATOM   250  H  HZ3  B LYS A 1 13  ? 17.09000  -21.76200 -8.60900  0.500 56.79911 ? 13  LYS A HZ3  1 
ATOM   251  N  N    A ARG A 1 14  ? 13.25500  -15.99300 -4.72300  0.500 24.70247 ? 14  ARG A N    1 
ATOM   252  N  N    B ARG A 1 14  ? 13.34300  -16.24500 -4.62300  0.500 24.26657 ? 14  ARG A N    1 
ATOM   253  C  CA   A ARG A 1 14  ? 13.78300  -14.73300 -4.22000  0.500 23.35330 ? 14  ARG A CA   1 
ATOM   254  C  CA   B ARG A 1 14  ? 14.02100  -15.07100 -4.08400  0.500 25.82448 ? 14  ARG A CA   1 
ATOM   255  C  C    A ARG A 1 14  ? 13.44900  -14.55400 -2.75200  0.500 31.31056 ? 14  ARG A C    1 
ATOM   256  C  C    B ARG A 1 14  ? 13.57400  -14.77500 -2.66300  0.500 30.38056 ? 14  ARG A C    1 
ATOM   257  O  O    A ARG A 1 14  ? 14.19100  -13.89800 -2.01700  0.500 29.31019 ? 14  ARG A O    1 
ATOM   258  O  O    B ARG A 1 14  ? 14.35800  -14.24000 -1.87400  0.500 27.37052 ? 14  ARG A O    1 
ATOM   259  C  CB   A ARG A 1 14  ? 13.22000  -13.57900 -5.04900  0.500 28.17821 ? 14  ARG A CB   1 
ATOM   260  C  CB   B ARG A 1 14  ? 13.79600  -13.84100 -4.96800  0.500 30.22994 ? 14  ARG A CB   1 
ATOM   261  C  CG   A ARG A 1 14  ? 13.66800  -12.21100 -4.58800  0.500 36.31264 ? 14  ARG A CG   1 
ATOM   262  C  CG   B ARG A 1 14  ? 14.77900  -12.70700 -4.65300  0.500 42.15354 ? 14  ARG A CG   1 
ATOM   263  C  CD   A ARG A 1 14  ? 13.40000  -11.15400 -5.65700  0.500 37.72535 ? 14  ARG A CD   1 
ATOM   264  C  CD   B ARG A 1 14  ? 14.50100  -11.43500 -5.44800  0.500 41.38748 ? 14  ARG A CD   1 
ATOM   265  N  NE   A ARG A 1 14  ? 12.11200  -10.49600 -5.48100  0.500 40.67984 ? 14  ARG A NE   1 
ATOM   266  N  NE   B ARG A 1 14  ? 14.04800  -10.33000 -4.60800  0.500 40.08296 ? 14  ARG A NE   1 
ATOM   267  C  CZ   A ARG A 1 14  ? 11.87800  -9.52100  -4.61300  0.500 38.73373 ? 14  ARG A CZ   1 
ATOM   268  C  CZ   B ARG A 1 14  ? 14.81500  -9.66700  -3.75100  0.500 37.81090 ? 14  ARG A CZ   1 
ATOM   269  N  NH1  A ARG A 1 14  ? 12.82800  -9.06700  -3.81300  0.500 35.64756 ? 14  ARG A NH1  1 
ATOM   270  N  NH1  B ARG A 1 14  ? 16.07600  -10.00600 -3.54500  0.500 34.51866 ? 14  ARG A NH1  1 
ATOM   271  N  NH2  A ARG A 1 14  ? 10.65800  -8.99700  -4.53800  0.500 51.80999 ? 14  ARG A NH2  1 
ATOM   272  N  NH2  B ARG A 1 14  ? 14.30000  -8.64400  -3.07500  0.500 41.38000 ? 14  ARG A NH2  1 
ATOM   273  H  H    A ARG A 1 14  ? 12.76600  -15.92300 -5.42700  0.500 29.64653 ? 14  ARG A H    1 
ATOM   274  H  H    B ARG A 1 14  ? 12.75700  -16.07400 -5.22900  0.500 29.12345 ? 14  ARG A H    1 
ATOM   275  H  HA   A ARG A 1 14  ? 14.74900  -14.72000 -4.31000  0.500 28.02753 ? 14  ARG A HA   1 
ATOM   276  H  HA   B ARG A 1 14  ? 14.97300  -15.25500 -4.08100  0.500 30.99294 ? 14  ARG A HA   1 
ATOM   277  H  HB2  A ARG A 1 14  ? 13.50800  -13.68800 -5.96900  0.500 33.81742 ? 14  ARG A HB2  1 
ATOM   278  H  HB2  B ARG A 1 14  ? 13.91300  -14.09300 -5.89800  0.500 36.27950 ? 14  ARG A HB2  1 
ATOM   279  H  HB3  A ARG A 1 14  ? 12.25200  -13.60400 -4.99900  0.500 33.81742 ? 14  ARG A HB3  1 
ATOM   280  H  HB3  B ARG A 1 14  ? 12.89600  -13.50800 -4.82600  0.500 36.27950 ? 14  ARG A HB3  1 
ATOM   281  H  HG2  A ARG A 1 14  ? 13.18100  -11.96600 -3.78600  0.500 43.57874 ? 14  ARG A HG2  1 
ATOM   282  H  HG2  B ARG A 1 14  ? 14.71600  -12.48900 -3.71000  0.500 50.58781 ? 14  ARG A HG2  1 
ATOM   283  H  HG3  A ARG A 1 14  ? 14.62000  -12.22800 -4.40600  0.500 43.57874 ? 14  ARG A HG3  1 
ATOM   284  H  HG3  B ARG A 1 14  ? 15.67800  -13.00100 -4.86700  0.500 50.58781 ? 14  ARG A HG3  1 
ATOM   285  H  HD2  A ARG A 1 14  ? 14.09300  -10.47600 -5.61200  0.500 45.27398 ? 14  ARG A HD2  1 
ATOM   286  H  HD2  B ARG A 1 14  ? 15.31600  -11.15700 -5.89400  0.500 49.66855 ? 14  ARG A HD2  1 
ATOM   287  H  HD3  A ARG A 1 14  ? 13.40500  -11.57700 -6.52900  0.500 45.27398 ? 14  ARG A HD3  1 
ATOM   288  H  HD3  B ARG A 1 14  ? 13.80900  -11.61600 -6.10300  0.500 49.66855 ? 14  ARG A HD3  1 
ATOM   289  H  HE   A ARG A 1 14  ? 11.45800  -10.75700 -5.97500  0.500 48.81938 ? 14  ARG A HE   1 
ATOM   290  H  HE   B ARG A 1 14  ? 13.22400  -10.09000 -4.67400  0.500 48.10312 ? 14  ARG A HE   1 
ATOM   291  H  HH11 A ARG A 1 14  ? 13.61900  -9.40400  -3.85000  0.500 42.78064 ? 14  ARG A HH11 1 
ATOM   292  H  HH11 B ARG A 1 14  ? 16.41800  -10.67000 -3.97200  0.500 41.42596 ? 14  ARG A HH11 1 
ATOM   293  H  HH12 A ARG A 1 14  ? 12.65600  -8.43400  -3.25700  0.500 42.78064 ? 14  ARG A HH12 1 
ATOM   294  H  HH12 B ARG A 1 14  ? 16.55500  -9.56300  -2.98500  0.500 41.42596 ? 14  ARG A HH12 1 
ATOM   295  H  HH21 A ARG A 1 14  ? 10.03200  -9.29000  -5.05000  0.500 62.17556 ? 14  ARG A HH21 1 
ATOM   296  H  HH21 B ARG A 1 14  ? 13.47900  -8.41800  -3.19600  0.500 49.65957 ? 14  ARG A HH21 1 
ATOM   297  H  HH22 A ARG A 1 14  ? 10.49600  -8.36500  -3.97900  0.500 62.17556 ? 14  ARG A HH22 1 
ATOM   298  H  HH22 B ARG A 1 14  ? 14.78800  -8.20800  -2.51800  0.500 49.65957 ? 14  ARG A HH22 1 
ATOM   299  N  N    . HIS A 1 15  ? 12.32200  -15.11300 -2.31400  1.000 25.48522 ? 15  HIS A N    1 
ATOM   300  C  CA   . HIS A 1 15  ? 11.84600  -14.94500 -0.94800  1.000 24.49294 ? 15  HIS A CA   1 
ATOM   301  C  C    . HIS A 1 15  ? 12.21500  -16.10200 -0.03500  1.000 25.26129 ? 15  HIS A C    1 
ATOM   302  O  O    . HIS A 1 15  ? 11.74400  -16.13600 1.10600   1.000 33.30175 ? 15  HIS A O    1 
ATOM   303  C  CB   . HIS A 1 15  ? 10.32800  -14.73200 -0.95300  1.000 29.30494 ? 15  HIS A CB   1 
ATOM   304  C  CG   . HIS A 1 15  ? 9.90800   -13.38300 -1.45300  1.000 26.52268 ? 15  HIS A CG   1 
ATOM   305  N  ND1  . HIS A 1 15  ? 9.84800   -12.27700 -0.63600  1.000 43.12090 ? 15  HIS A ND1  1 
ATOM   306  C  CD2  . HIS A 1 15  ? 9.55100   -12.96000 -2.69000  1.000 27.83991 ? 15  HIS A CD2  1 
ATOM   307  C  CE1  . HIS A 1 15  ? 9.45800   -11.23100 -1.34400  1.000 41.24862 ? 15  HIS A CE1  1 
ATOM   308  N  NE2  . HIS A 1 15  ? 9.26700   -11.61900 -2.59200  1.000 37.93086 ? 15  HIS A NE2  1 
ATOM   309  H  H    . HIS A 1 15  ? 11.73600  -15.44000 -2.85200  1.000 30.58583 ? 15  HIS A H    1 
ATOM   310  H  HA   . HIS A 1 15  ? 12.25800  -14.15100 -0.57400  1.000 29.39510 ? 15  HIS A HA   1 
ATOM   311  H  HB2  . HIS A 1 15  ? 9.92100   -15.39900 -1.52800  1.000 35.16950 ? 15  HIS A HB2  1 
ATOM   312  H  HB3  . HIS A 1 15  ? 9.99700   -14.82800 -0.04700  1.000 35.16950 ? 15  HIS A HB3  1 
ATOM   313  H  HD1  . HIS A 1 15  ? 10.03500  -12.26700 0.20400   1.000 51.74865 ? 15  HIS A HD1  1 
ATOM   314  H  HD2  . HIS A 1 15  ? 9.50600   -13.48000 -3.46000  1.000 33.41146 ? 15  HIS A HD2  1 
ATOM   315  H  HE1  . HIS A 1 15  ? 9.33800   -10.36800 -1.01800  1.000 49.50191 ? 15  HIS A HE1  1 
ATOM   316  N  N    . GLY A 1 16  ? 13.05800  -17.02400 -0.49000  1.000 24.60287 ? 16  GLY A N    1 
ATOM   317  C  CA   . GLY A 1 16  ? 13.65500  -18.00000 0.39500   1.000 27.75606 ? 16  GLY A CA   1 
ATOM   318  C  C    . GLY A 1 16  ? 12.88800  -19.29100 0.57100   1.000 27.44282 ? 16  GLY A C    1 
ATOM   319  O  O    . GLY A 1 16  ? 13.16100  -20.03500 1.51900   1.000 28.21449 ? 16  GLY A O    1 
ATOM   320  H  H    . GLY A 1 16  ? 13.29800  -17.10100 -1.31300  1.000 29.52701 ? 16  GLY A H    1 
ATOM   321  H  HA2  . GLY A 1 16  ? 14.53300  -18.22800 0.05200   1.000 33.31084 ? 16  GLY A HA2  1 
ATOM   322  H  HA3  . GLY A 1 16  ? 13.75300  -17.59800 1.27200   1.000 33.31084 ? 16  GLY A HA3  1 
ATOM   323  N  N    . LEU A 1 17  ? 11.96600  -19.60700 -0.32300  1.000 26.60197 ? 17  LEU A N    1 
ATOM   324  C  CA   . LEU A 1 17  ? 11.17200  -20.81500 -0.13600  1.000 23.54979 ? 17  LEU A CA   1 
ATOM   325  C  C    . LEU A 1 17  ? 11.79800  -22.07700 -0.69500  1.000 28.95441 ? 17  LEU A C    1 
ATOM   326  O  O    . LEU A 1 17  ? 11.36500  -23.17100 -0.32100  1.000 25.22488 ? 17  LEU A O    1 
ATOM   327  C  CB   . LEU A 1 17  ? 9.77500   -20.65300 -0.74500  1.000 23.76752 ? 17  LEU A CB   1 
ATOM   328  C  CG   . LEU A 1 17  ? 8.82800   -19.87900 0.13400   1.000 24.96003 ? 17  LEU A CG   1 
ATOM   329  C  CD1  . LEU A 1 17  ? 7.47500   -19.85900 -0.52500  1.000 24.19871 ? 17  LEU A CD1  1 
ATOM   330  C  CD2  . LEU A 1 17  ? 8.64900   -20.48200 1.50300   1.000 27.22735 ? 17  LEU A CD2  1 
ATOM   331  H  H    . LEU A 1 17  ? 11.78300  -19.15100 -1.03000  1.000 31.92593 ? 17  LEU A H    1 
ATOM   332  H  HA   . LEU A 1 17  ? 11.07800  -20.93700 0.82200   1.000 28.26331 ? 17  LEU A HA   1 
ATOM   333  H  HB2  . LEU A 1 17  ? 9.85400   -20.18000 -1.58900  1.000 28.52459 ? 17  LEU A HB2  1 
ATOM   334  H  HB3  . LEU A 1 17  ? 9.39400   -21.53300 -0.89300  1.000 28.52459 ? 17  LEU A HB3  1 
ATOM   335  H  HG   . LEU A 1 17  ? 9.20300   -18.99200 0.25100   1.000 29.95561 ? 17  LEU A HG   1 
ATOM   336  H  HD11 . LEU A 1 17  ? 6.83900   -19.43600 0.07200   1.000 29.04202 ? 17  LEU A HD11 1 
ATOM   337  H  HD12 . LEU A 1 17  ? 7.53400   -19.35900 -1.35400  1.000 29.04202 ? 17  LEU A HD12 1 
ATOM   338  H  HD13 . LEU A 1 17  ? 7.20000   -20.77100 -0.70800  1.000 29.04202 ? 17  LEU A HD13 1 
ATOM   339  H  HD21 . LEU A 1 17  ? 7.84600   -20.11700 1.90600   1.000 32.67639 ? 17  LEU A HD21 1 
ATOM   340  H  HD22 . LEU A 1 17  ? 8.56800   -21.44400 1.41600   1.000 32.67639 ? 17  LEU A HD22 1 
ATOM   341  H  HD23 . LEU A 1 17  ? 9.42200   -20.26300 2.04800   1.000 32.67639 ? 17  LEU A HD23 1 
ATOM   342  N  N    A ASP A 1 18  ? 12.77100  -21.98700 -1.60200  0.580 27.19073 ? 18  ASP A N    1 
ATOM   343  N  N    B ASP A 1 18  ? 12.81800  -21.96400 -1.54100  0.420 27.02937 ? 18  ASP A N    1 
ATOM   344  C  CA   A ASP A 1 18  ? 13.34800  -23.19700 -2.16700  0.580 26.62073 ? 18  ASP A CA   1 
ATOM   345  C  CA   B ASP A 1 18  ? 13.45500  -23.14300 -2.10300  0.420 26.79323 ? 18  ASP A CA   1 
ATOM   346  C  C    A ASP A 1 18  ? 14.06200  -23.94800 -1.05600  0.580 29.38935 ? 18  ASP A C    1 
ATOM   347  C  C    B ASP A 1 18  ? 14.13400  -23.94600 -0.99900  0.420 29.65923 ? 18  ASP A C    1 
ATOM   348  O  O    A ASP A 1 18  ? 15.00200  -23.41700 -0.45200  0.580 28.60358 ? 18  ASP A O    1 
ATOM   349  O  O    B ASP A 1 18  ? 15.06800  -23.46300 -0.35100  0.420 29.03463 ? 18  ASP A O    1 
ATOM   350  C  CB   A ASP A 1 18  ? 14.32400  -22.86800 -3.29300  0.580 29.61503 ? 18  ASP A CB   1 
ATOM   351  C  CB   B ASP A 1 18  ? 14.46000  -22.73300 -3.18300  0.420 29.73756 ? 18  ASP A CB   1 
ATOM   352  C  CG   A ASP A 1 18  ? 14.75600  -24.10500 -4.09300  0.580 32.23243 ? 18  ASP A CG   1 
ATOM   353  C  CG   B ASP A 1 18  ? 15.38000  -21.60400 -2.74200  0.420 33.56967 ? 18  ASP A CG   1 
ATOM   354  O  OD1  A ASP A 1 18  ? 14.16300  -25.20000 -3.93600  0.580 26.06119 ? 18  ASP A OD1  1 
ATOM   355  O  OD1  B ASP A 1 18  ? 14.87100  -20.53400 -2.34100  0.420 27.03309 ? 18  ASP A OD1  1 
ATOM   356  O  OD2  A ASP A 1 18  ? 15.70800  -23.98000 -4.90300  0.580 37.06037 ? 18  ASP A OD2  1 
ATOM   357  O  OD2  B ASP A 1 18  ? 16.61500  -21.78500 -2.82100  0.420 44.51471 ? 18  ASP A OD2  1 
ATOM   358  H  H    A ASP A 1 18  ? 13.10500  -21.25200 -1.89700  0.580 32.63245 ? 18  ASP A H    1 
ATOM   359  H  H    B ASP A 1 18  ? 13.15700  -21.21800 -1.80300  0.420 32.43882 ? 18  ASP A H    1 
ATOM   360  H  HA   A ASP A 1 18  ? 12.64500  -23.74800 -2.54500  0.580 31.94845 ? 18  ASP A HA   1 
ATOM   361  H  HA   B ASP A 1 18  ? 12.78600  -23.70700 -2.52100  0.420 32.15544 ? 18  ASP A HA   1 
ATOM   362  H  HB2  A ASP A 1 18  ? 13.90000  -22.24800 -3.90600  0.580 35.54160 ? 18  ASP A HB2  1 
ATOM   363  H  HB2  B ASP A 1 18  ? 15.01100  -23.49800 -3.40700  0.420 35.68864 ? 18  ASP A HB2  1 
ATOM   364  H  HB3  A ASP A 1 18  ? 15.12000  -22.46600 -2.91200  0.580 35.54160 ? 18  ASP A HB3  1 
ATOM   365  H  HB3  B ASP A 1 18  ? 13.97400  -22.43300 -3.96700  0.420 35.68864 ? 18  ASP A HB3  1 
ATOM   366  N  N    A ASN A 1 19  ? 13.59300  -25.16600 -0.77900  0.610 24.38213 ? 19  ASN A N    1 
ATOM   367  N  N    B ASN A 1 19  ? 13.64600  -25.17500 -0.79600  0.390 24.38422 ? 19  ASN A N    1 
ATOM   368  C  CA   A ASN A 1 19  ? 14.11100  -26.05800 0.25200   0.610 22.19784 ? 19  ASN A CA   1 
ATOM   369  C  CA   B ASN A 1 19  ? 14.06300  -26.10100 0.25700   0.390 22.30611 ? 19  ASN A CA   1 
ATOM   370  C  C    A ASN A 1 19  ? 13.87400  -25.54400 1.66800   0.610 22.38042 ? 19  ASN A C    1 
ATOM   371  C  C    B ASN A 1 19  ? 13.87300  -25.54200 1.66900   0.390 22.49028 ? 19  ASN A C    1 
ATOM   372  O  O    A ASN A 1 19  ? 14.49400  -26.03700 2.61900   0.610 25.85431 ? 19  ASN A O    1 
ATOM   373  O  O    B ASN A 1 19  ? 14.53600  -25.98800 2.61200   0.390 26.04642 ? 19  ASN A O    1 
ATOM   374  C  CB   A ASN A 1 19  ? 15.57400  -26.42900 -0.02000  0.610 27.62061 ? 19  ASN A CB   1 
ATOM   375  C  CB   B ASN A 1 19  ? 15.48200  -26.64300 0.03900   0.390 29.46980 ? 19  ASN A CB   1 
ATOM   376  C  CG   A ASN A 1 19  ? 15.72500  -27.25600 -1.28900  0.610 31.22362 ? 19  ASN A CG   1 
ATOM   377  C  CG   B ASN A 1 19  ? 15.58000  -28.13500 0.31800   0.390 29.35275 ? 19  ASN A CG   1 
ATOM   378  O  OD1  A ASN A 1 19  ? 15.11900  -28.31700 -1.42700  0.610 40.64919 ? 19  ASN A OD1  1 
ATOM   379  O  OD1  B ASN A 1 19  ? 14.65900  -28.90500 0.02600   0.390 31.59241 ? 19  ASN A OD1  1 
ATOM   380  N  ND2  A ASN A 1 19  ? 16.52800  -26.76700 -2.22300  0.610 39.10362 ? 19  ASN A ND2  1 
ATOM   381  N  ND2  B ASN A 1 19  ? 16.70500  -28.55200 0.89600   0.390 36.93718 ? 19  ASN A ND2  1 
ATOM   382  H  H    A ASN A 1 19  ? 12.93300  -25.51700 -1.20400  0.610 29.26213 ? 19  ASN A H    1 
ATOM   383  H  H    B ASN A 1 19  ? 13.03100  -25.51500 -1.29100  0.390 29.26464 ? 19  ASN A H    1 
ATOM   384  H  HA   A ASN A 1 19  ? 13.61600  -26.89200 0.22000   0.610 26.64098 ? 19  ASN A HA   1 
ATOM   385  H  HA   B ASN A 1 19  ? 13.47600  -26.87100 0.20400   0.390 26.77090 ? 19  ASN A HA   1 
ATOM   386  H  HB2  A ASN A 1 19  ? 16.09500  -25.61700 -0.12400  0.610 33.14830 ? 19  ASN A HB2  1 
ATOM   387  H  HB2  B ASN A 1 19  ? 15.74200  -26.49100 -0.88300  0.390 35.36732 ? 19  ASN A HB2  1 
ATOM   388  H  HB3  A ASN A 1 19  ? 15.91500  -26.95000 0.72300   0.610 33.14830 ? 19  ASN A HB3  1 
ATOM   389  H  HB3  B ASN A 1 19  ? 16.09300  -26.18400 0.63600   0.390 35.36732 ? 19  ASN A HB3  1 
ATOM   390  H  HD21 A ASN A 1 19  ? 16.64600  -27.19800 -2.95700  0.610 46.92792 ? 19  ASN A HD21 1 
ATOM   391  H  HD21 B ASN A 1 19  ? 16.81200  -29.38600 1.07600   0.390 44.32818 ? 19  ASN A HD21 1 
ATOM   392  H  HD22 A ASN A 1 19  ? 16.93200  -26.01900 -2.09400  0.610 46.92792 ? 19  ASN A HD22 1 
ATOM   393  H  HD22 B ASN A 1 19  ? 17.32400  -27.98700 1.08900   0.390 44.32818 ? 19  ASN A HD22 1 
ATOM   394  N  N    . TYR A 1 20  ? 12.95400  -24.59400 1.85400   1.000 23.56015 ? 20  TYR A N    1 
ATOM   395  C  CA   . TYR A 1 20  ? 12.61600  -24.13000 3.19000   1.000 23.07040 ? 20  TYR A CA   1 
ATOM   396  C  C    . TYR A 1 20  ? 11.98100  -25.28000 3.96600   1.000 23.01511 ? 20  TYR A C    1 
ATOM   397  O  O    . TYR A 1 20  ? 10.98600  -25.86000 3.52800   1.000 22.94215 ? 20  TYR A O    1 
ATOM   398  C  CB   . TYR A 1 20  ? 11.67300  -22.92900 3.14800   1.000 24.74357 ? 20  TYR A CB   1 
ATOM   399  C  CG   . TYR A 1 20  ? 11.52100  -22.29700 4.49400   1.000 24.31240 ? 20  TYR A CG   1 
ATOM   400  C  CD1  . TYR A 1 20  ? 12.47500  -21.40700 4.97100   1.000 27.38174 ? 20  TYR A CD1  1 
ATOM   401  C  CD2  . TYR A 1 20  ? 10.45800  -22.62100 5.32800   1.000 24.25015 ? 20  TYR A CD2  1 
ATOM   402  C  CE1  . TYR A 1 20  ? 12.35600  -20.84400 6.22700   1.000 35.18733 ? 20  TYR A CE1  1 
ATOM   403  C  CE2  . TYR A 1 20  ? 10.33200  -22.06300 6.56200   1.000 25.00138 ? 20  TYR A CE2  1 
ATOM   404  C  CZ   . TYR A 1 20  ? 11.29000  -21.18600 7.02000   1.000 30.81535 ? 20  TYR A CZ   1 
ATOM   405  O  OH   . TYR A 1 20  ? 11.16200  -20.62600 8.26600   1.000 33.47476 ? 20  TYR A OH   1 
ATOM   406  H  H    . TYR A 1 20  ? 12.51700  -24.20800 1.22100   1.000 28.27575 ? 20  TYR A H    1 
ATOM   407  H  HA   . TYR A 1 20  ? 13.42400  -23.83400 3.63800   1.000 27.68804 ? 20  TYR A HA   1 
ATOM   408  H  HB2  . TYR A 1 20  ? 12.02900  -22.26400 2.53800   1.000 29.69586 ? 20  TYR A HB2  1 
ATOM   409  H  HB3  . TYR A 1 20  ? 10.79800  -23.22000 2.84700   1.000 29.69586 ? 20  TYR A HB3  1 
ATOM   410  H  HD1  . TYR A 1 20  ? 13.20400  -21.18700 4.43700   1.000 32.86166 ? 20  TYR A HD1  1 
ATOM   411  H  HD2  . TYR A 1 20  ? 9.82000   -23.23200 5.03700   1.000 29.10375 ? 20  TYR A HD2  1 
ATOM   412  H  HE1  . TYR A 1 20  ? 12.99200  -20.23800 6.53200   1.000 42.22837 ? 20  TYR A HE1  1 
ATOM   413  H  HE2  . TYR A 1 20  ? 9.60000   -22.27300 7.09500   1.000 30.00522 ? 20  TYR A HE2  1 
ATOM   414  H  HH   . TYR A 1 20  ? 10.58800  -21.04600 8.71200   1.000 40.17328 ? 20  TYR A HH   1 
ATOM   415  N  N    A ARG A 1 21  ? 12.57300  -25.60600 5.11600   0.450 23.81510 ? 21  ARG A N    1 
ATOM   416  N  N    B ARG A 1 21  ? 12.56500  -25.60500 5.12000   0.550 23.72453 ? 21  ARG A N    1 
ATOM   417  C  CA   A ARG A 1 21  ? 12.18000  -26.76200 5.92200   0.450 23.17719 ? 21  ARG A CA   1 
ATOM   418  C  CA   B ARG A 1 21  ? 12.17700  -26.76700 5.91900   0.550 23.09887 ? 21  ARG A CA   1 
ATOM   419  C  C    A ARG A 1 21  ? 12.17900  -28.05300 5.10700   0.450 21.78654 ? 21  ARG A C    1 
ATOM   420  C  C    B ARG A 1 21  ? 12.17900  -28.05600 5.10400   0.550 21.72658 ? 21  ARG A C    1 
ATOM   421  O  O    A ARG A 1 21  ? 11.41400  -28.98100 5.38400   0.450 23.67742 ? 21  ARG A O    1 
ATOM   422  O  O    B ARG A 1 21  ? 11.41800  -28.98700 5.38200   0.550 23.66477 ? 21  ARG A O    1 
ATOM   423  C  CB   A ARG A 1 21  ? 10.84700  -26.52800 6.63500   0.450 26.63128 ? 21  ARG A CB   1 
ATOM   424  C  CB   B ARG A 1 21  ? 10.84200  -26.55000 6.63000   0.550 26.69845 ? 21  ARG A CB   1 
ATOM   425  C  CG   A ARG A 1 21  ? 10.94300  -25.55800 7.80000   0.450 35.18913 ? 21  ARG A CG   1 
ATOM   426  C  CG   B ARG A 1 21  ? 10.85200  -25.38400 7.58200   0.550 33.75985 ? 21  ARG A CG   1 
ATOM   427  C  CD   A ARG A 1 21  ? 11.02900  -26.27400 9.14200   0.450 36.35034 ? 21  ARG A CD   1 
ATOM   428  C  CD   B ARG A 1 21  ? 11.62400  -25.69600 8.85400   0.550 34.95648 ? 21  ARG A CD   1 
ATOM   429  N  NE   A ARG A 1 21  ? 11.43600  -25.36600 10.21000  0.450 46.33483 ? 21  ARG A NE   1 
ATOM   430  N  NE   B ARG A 1 21  ? 11.74300  -24.50500 9.68700   0.550 38.73778 ? 21  ARG A NE   1 
ATOM   431  C  CZ   A ARG A 1 21  ? 11.26200  -25.59600 11.50500  0.450 38.14323 ? 21  ARG A CZ   1 
ATOM   432  C  CZ   B ARG A 1 21  ? 12.79400  -23.69400 9.70900   0.550 43.13748 ? 21  ARG A CZ   1 
ATOM   433  N  NH1  A ARG A 1 21  ? 10.68600  -26.70400 11.93900  0.450 36.94100 ? 21  ARG A NH1  1 
ATOM   434  N  NH1  B ARG A 1 21  ? 13.88300  -23.94500 8.99800   0.550 50.81129 ? 21  ARG A NH1  1 
ATOM   435  N  NH2  A ARG A 1 21  ? 11.67200  -24.68900 12.38700  0.450 47.39778 ? 21  ARG A NH2  1 
ATOM   436  N  NH2  B ARG A 1 21  ? 12.75100  -22.60300 10.46900  0.550 48.40378 ? 21  ARG A NH2  1 
ATOM   437  H  H    A ARG A 1 21  ? 13.22300  -25.16100 5.46100   0.450 28.58169 ? 21  ARG A H    1 
ATOM   438  H  H    B ARG A 1 21  ? 13.20800  -25.15400 5.47200   0.550 28.47300 ? 21  ARG A H    1 
ATOM   439  H  HA   A ARG A 1 21  ? 12.84700  -26.88200 6.61600   0.450 27.81619 ? 21  ARG A HA   1 
ATOM   440  H  HA   B ARG A 1 21  ? 12.84800  -26.88200 6.61000   0.550 27.72221 ? 21  ARG A HA   1 
ATOM   441  H  HB2  A ARG A 1 21  ? 10.21100  -26.16600 5.99800   0.450 31.96111 ? 21  ARG A HB2  1 
ATOM   442  H  HB2  B ARG A 1 21  ? 10.15700  -26.38300 5.96300   0.550 32.04171 ? 21  ARG A HB2  1 
ATOM   443  H  HB3  A ARG A 1 21  ? 10.52400  -27.37500 6.98000   0.450 31.96111 ? 21  ARG A HB3  1 
ATOM   444  H  HB3  B ARG A 1 21  ? 10.62500  -27.34700 7.13700   0.550 32.04171 ? 21  ARG A HB3  1 
ATOM   445  H  HG2  A ARG A 1 21  ? 11.73900  -25.01400 7.69700   0.450 42.23052 ? 21  ARG A HG2  1 
ATOM   446  H  HG2  B ARG A 1 21  ? 11.27100  -24.62300 7.15200   0.550 40.51539 ? 21  ARG A HG2  1 
ATOM   447  H  HG3  A ARG A 1 21  ? 10.15400  -24.99300 7.81000   0.450 42.23052 ? 21  ARG A HG3  1 
ATOM   448  H  HG3  B ARG A 1 21  ? 9.93900   -25.16500 7.82900   0.550 40.51539 ? 21  ARG A HG3  1 
ATOM   449  H  HD2  A ARG A 1 21  ? 10.15900  -26.63800 9.36800   0.450 43.62398 ? 21  ARG A HD2  1 
ATOM   450  H  HD2  B ARG A 1 21  ? 11.15700  -26.38000 9.35800   0.550 41.95134 ? 21  ARG A HD2  1 
ATOM   451  H  HD3  A ARG A 1 21  ? 11.68300  -26.98800 9.08300   0.450 43.62398 ? 21  ARG A HD3  1 
ATOM   452  H  HD3  B ARG A 1 21  ? 12.51600  -26.00300 8.62500   0.550 41.95134 ? 21  ARG A HD3  1 
ATOM   453  H  HE   A ARG A 1 21  ? 11.81600  -24.62800 9.98400   0.450 55.60536 ? 21  ARG A HE   1 
ATOM   454  H  HE   B ARG A 1 21  ? 11.08200  -24.31300 10.20200  0.550 46.48891 ? 21  ARG A HE   1 
ATOM   455  H  HH11 A ARG A 1 21  ? 10.41400  -27.29600 11.37700  0.450 44.33277 ? 21  ARG A HH11 1 
ATOM   456  H  HH11 B ARG A 1 21  ? 13.92200  -24.64800 8.50500   0.550 60.97712 ? 21  ARG A HH11 1 
ATOM   457  H  HH12 A ARG A 1 21  ? 10.58300  -26.83300 12.78300  0.450 44.33277 ? 21  ARG A HH12 1 
ATOM   458  H  HH12 B ARG A 1 21  ? 14.55100  -23.40400 9.02900   0.550 60.97712 ? 21  ARG A HH12 1 
ATOM   459  H  HH21 A ARG A 1 21  ? 12.04500  -23.96300 12.11500  0.450 56.88091 ? 21  ARG A HH21 1 
ATOM   460  H  HH21 B ARG A 1 21  ? 12.05000  -22.43200 10.93700  0.550 58.08810 ? 21  ARG A HH21 1 
ATOM   461  H  HH22 A ARG A 1 21  ? 11.56500  -24.82800 13.22900  0.450 56.88091 ? 21  ARG A HH22 1 
ATOM   462  H  HH22 B ARG A 1 21  ? 13.42500  -22.06900 10.49300  0.550 58.08810 ? 21  ARG A HH22 1 
ATOM   463  N  N    . GLY A 1 22  ? 13.06000  -28.13100 4.11300   1.000 21.82671 ? 22  GLY A N    1 
ATOM   464  C  CA   . GLY A 1 22  ? 13.20300  -29.31100 3.29900   1.000 21.42299 ? 22  GLY A CA   1 
ATOM   465  C  C    . GLY A 1 22  ? 12.23800  -29.46100 2.14100   1.000 20.83499 ? 22  GLY A C    1 
ATOM   466  O  O    . GLY A 1 22  ? 12.25500  -30.50400 1.48400   1.000 21.61622 ? 22  GLY A O    1 
ATOM   467  H  H    . GLY A 1 22  ? 13.59400  -27.49300 3.89400   1.000 26.19562 ? 22  GLY A H    1 
ATOM   468  H  HA2  . GLY A 1 22  ? 14.10000  -29.31700 2.92900   1.000 25.71116 ? 22  GLY A HA2  1 
ATOM   469  H  HA3  . GLY A 1 22  ? 13.09200  -30.08800 3.86900   1.000 25.71116 ? 22  GLY A HA3  1 
ATOM   470  N  N    . TYR A 1 23  ? 11.40700  -28.45100 1.86000   1.000 21.50088 ? 23  TYR A N    1 
ATOM   471  C  CA   . TYR A 1 23  ? 10.42700  -28.54500 0.77600   1.000 19.17312 ? 23  TYR A CA   1 
ATOM   472  C  C    . TYR A 1 23  ? 10.96400  -27.82400 -0.44500  1.000 17.34614 ? 23  TYR A C    1 
ATOM   473  O  O    . TYR A 1 23  ? 11.05900  -26.59800 -0.45500  1.000 19.40950 ? 23  TYR A O    1 
ATOM   474  C  CB   . TYR A 1 23  ? 9.07000   -27.98900 1.20600   1.000 18.00737 ? 23  TYR A CB   1 
ATOM   475  C  CG   . TYR A 1 23  ? 8.39000   -28.85500 2.24200   1.000 15.46275 ? 23  TYR A CG   1 
ATOM   476  C  CD1  . TYR A 1 23  ? 7.59000   -29.90200 1.85800   1.000 17.66709 ? 23  TYR A CD1  1 
ATOM   477  C  CD2  . TYR A 1 23  ? 8.56500   -28.61300 3.61800   1.000 18.44208 ? 23  TYR A CD2  1 
ATOM   478  C  CE1  . TYR A 1 23  ? 6.95800   -30.68200 2.78800   1.000 16.19395 ? 23  TYR A CE1  1 
ATOM   479  C  CE2  . TYR A 1 23  ? 7.95300   -29.42800 4.56800   1.000 17.04933 ? 23  TYR A CE2  1 
ATOM   480  C  CZ   . TYR A 1 23  ? 7.11300   -30.44400 4.12000   1.000 16.87891 ? 23  TYR A CZ   1 
ATOM   481  O  OH   . TYR A 1 23  ? 6.46700   -31.28800 5.01300   1.000 19.13470 ? 23  TYR A OH   1 
ATOM   482  H  H    . TYR A 1 23  ? 11.39300  -27.70300 2.28400   1.000 25.80463 ? 23  TYR A H    1 
ATOM   483  H  HA   . TYR A 1 23  ? 10.30800  -29.47800 0.54200   1.000 23.01131 ? 23  TYR A HA   1 
ATOM   484  H  HB2  . TYR A 1 23  ? 9.19600   -27.10600 1.58800   1.000 21.61242 ? 23  TYR A HB2  1 
ATOM   485  H  HB3  . TYR A 1 23  ? 8.48900   -27.93600 0.43100   1.000 21.61242 ? 23  TYR A HB3  1 
ATOM   486  H  HD1  . TYR A 1 23  ? 7.47700   -30.08400 0.95300   1.000 21.20408 ? 23  TYR A HD1  1 
ATOM   487  H  HD2  . TYR A 1 23  ? 9.09500   -27.90100 3.89600   1.000 22.13407 ? 23  TYR A HD2  1 
ATOM   488  H  HE1  . TYR A 1 23  ? 6.41600   -31.38300 2.50700   1.000 19.43631 ? 23  TYR A HE1  1 
ATOM   489  H  HE2  . TYR A 1 23  ? 8.10200   -29.29700 5.47700   1.000 20.46277 ? 23  TYR A HE2  1 
ATOM   490  H  HH   . TYR A 1 23  ? 6.73300   -31.13700 5.79500   1.000 22.96521 ? 23  TYR A HH   1 
ATOM   491  N  N    . SER A 1 24  ? 11.24600  -28.60400 -1.47400  1.000 19.52143 ? 24  SER A N    1 
ATOM   492  C  CA   . SER A 1 24  ? 11.74100  -28.05700 -2.72800  1.000 19.84133 ? 24  SER A CA   1 
ATOM   493  C  C    . SER A 1 24  ? 10.71900  -27.11000 -3.35400  1.000 19.84384 ? 24  SER A C    1 
ATOM   494  O  O    . SER A 1 24  ? 9.50000   -27.17900 -3.11400  1.000 19.73380 ? 24  SER A O    1 
ATOM   495  C  CB   . SER A 1 24  ? 12.08800  -29.18700 -3.68600  1.000 22.60143 ? 24  SER A CB   1 
ATOM   496  O  OG   . SER A 1 24  ? 10.92700  -29.85400 -4.13300  1.000 27.72323 ? 24  SER A OG   1 
ATOM   497  H  H    . SER A 1 24  ? 11.16000  -29.46000 -1.47400  1.000 23.42928 ? 24  SER A H    1 
ATOM   498  H  HA   . SER A 1 24  ? 12.54600  -27.54200 -2.56400  1.000 23.81317 ? 24  SER A HA   1 
ATOM   499  H  HB2  . SER A 1 24  ? 12.55300  -28.81700 -4.45300  1.000 27.12529 ? 24  SER A HB2  1 
ATOM   500  H  HB3  . SER A 1 24  ? 12.65900  -29.82300 -3.22700  1.000 27.12529 ? 24  SER A HB3  1 
ATOM   501  H  HG   . SER A 1 24  ? 10.53300  -30.21200 -3.48300  1.000 33.27145 ? 24  SER A HG   1 
ATOM   502  N  N    . LEU A 1 25  ? 11.23500  -26.20800 -4.18000  1.000 19.94530 ? 25  LEU A N    1 
ATOM   503  C  CA   . LEU A 1 25  ? 10.42800  -25.18000 -4.80000  1.000 19.96388 ? 25  LEU A CA   1 
ATOM   504  C  C    . LEU A 1 25  ? 9.19600   -25.71200 -5.49900  1.000 19.66210 ? 25  LEU A C    1 
ATOM   505  O  O    . LEU A 1 25  ? 8.12200   -25.09500 -5.41700  1.000 18.31720 ? 25  LEU A O    1 
ATOM   506  C  CB   . LEU A 1 25  ? 11.30100  -24.39800 -5.78000  1.000 22.45270 ? 25  LEU A CB   1 
ATOM   507  C  CG   . LEU A 1 25  ? 10.78600  -23.07200 -6.27200  1.000 23.01316 ? 25  LEU A CG   1 
ATOM   508  C  CD1  . LEU A 1 25  ? 10.51600  -22.12100 -5.10300  1.000 26.99641 ? 25  LEU A CD1  1 
ATOM   509  C  CD2  . LEU A 1 25  ? 11.83600  -22.47900 -7.22100  1.000 25.23479 ? 25  LEU A CD2  1 
ATOM   510  H  H    . LEU A 1 25  ? 12.06500  -26.17200 -4.39900  1.000 23.93793 ? 25  LEU A H    1 
ATOM   511  H  HA   . LEU A 1 25  ? 10.10500  -24.58900 -4.10200  1.000 23.96022 ? 25  LEU A HA   1 
ATOM   512  H  HB2  . LEU A 1 25  ? 12.15000  -24.22400 -5.34500  1.000 26.94680 ? 25  LEU A HB2  1 
ATOM   513  H  HB3  . LEU A 1 25  ? 11.43700  -24.95300 -6.56300  1.000 26.94680 ? 25  LEU A HB3  1 
ATOM   514  H  HG   . LEU A 1 25  ? 9.94500   -23.18800 -6.74100  1.000 27.61936 ? 25  LEU A HG   1 
ATOM   515  H  HD11 . LEU A 1 25  ? 10.41100  -21.22000 -5.44600  1.000 32.39926 ? 25  LEU A HD11 1 
ATOM   516  H  HD12 . LEU A 1 25  ? 9.70500   -22.39900 -4.65000  1.000 32.39926 ? 25  LEU A HD12 1 
ATOM   517  H  HD13 . LEU A 1 25  ? 11.26600  -22.15500 -4.48800  1.000 32.39926 ? 25  LEU A HD13 1 
ATOM   518  H  HD21 . LEU A 1 25  ? 11.68600  -21.52400 -7.30100  1.000 30.28532 ? 25  LEU A HD21 1 
ATOM   519  H  HD22 . LEU A 1 25  ? 12.72000  -22.64600 -6.85800  1.000 30.28532 ? 25  LEU A HD22 1 
ATOM   520  H  HD23 . LEU A 1 25  ? 11.75000  -22.90100 -8.09000  1.000 30.28532 ? 25  LEU A HD23 1 
ATOM   521  N  N    . GLY A 1 26  ? 9.30000   -26.83000 -6.20200  1.000 19.16050 ? 26  GLY A N    1 
ATOM   522  C  CA   . GLY A 1 26  ? 8.14000   -27.37500 -6.89100  1.000 19.34249 ? 26  GLY A CA   1 
ATOM   523  C  C    . GLY A 1 26  ? 6.97000   -27.67300 -5.97000  1.000 18.11127 ? 26  GLY A C    1 
ATOM   524  O  O    . GLY A 1 26  ? 5.81400   -27.60800 -6.39400  1.000 18.16694 ? 26  GLY A O    1 
ATOM   525  H  H    . GLY A 1 26  ? 10.02100  -27.28800 -6.29700  1.000 22.99617 ? 26  GLY A H    1 
ATOM   526  H  HA2  . GLY A 1 26  ? 7.84200   -26.74000 -7.56000  1.000 23.21456 ? 26  GLY A HA2  1 
ATOM   527  H  HA3  . GLY A 1 26  ? 8.39400   -28.20200 -7.33100  1.000 23.21456 ? 26  GLY A HA3  1 
ATOM   528  N  N    . ASN A 1 27  ? 7.23900   -28.01300 -4.70700  1.000 16.59226 ? 27  ASN A N    1 
ATOM   529  C  CA   . ASN A 1 27  ? 6.14600   -28.26100 -3.75800  1.000 15.76535 ? 27  ASN A CA   1 
ATOM   530  C  C    . ASN A 1 27  ? 5.33400   -26.99900 -3.54100  1.000 17.51708 ? 27  ASN A C    1 
ATOM   531  O  O    . ASN A 1 27  ? 4.10200   -27.05900 -3.50000  1.000 16.83635 ? 27  ASN A O    1 
ATOM   532  C  CB   . ASN A 1 27  ? 6.68200   -28.73900 -2.40500  1.000 16.41682 ? 27  ASN A CB   1 
ATOM   533  C  CG   . ASN A 1 27  ? 7.07200   -30.16900 -2.41100  1.000 17.22408 ? 27  ASN A CG   1 
ATOM   534  O  OD1  . ASN A 1 27  ? 6.25700   -31.05500 -2.42900  1.000 18.69873 ? 27  ASN A OD1  1 
ATOM   535  N  ND2  . ASN A 1 27  ? 8.38600   -30.39200 -2.47700  1.000 20.13393 ? 27  ASN A ND2  1 
ATOM   536  H  H    . ASN A 1 27  ? 8.02800   -28.10500 -4.37800  1.000 19.91428 ? 27  ASN A H    1 
ATOM   537  H  HA   . ASN A 1 27  ? 5.58600   -28.96200 -4.12700  1.000 18.92199 ? 27  ASN A HA   1 
ATOM   538  H  HB2  . ASN A 1 27  ? 7.46600   -28.21600 -2.17300  1.000 19.70376 ? 27  ASN A HB2  1 
ATOM   539  H  HB3  . ASN A 1 27  ? 5.99300   -28.61900 -1.73200  1.000 19.70376 ? 27  ASN A HB3  1 
ATOM   540  H  HD21 . ASN A 1 27  ? 8.68600   -31.19800 -2.48500  1.000 24.16428 ? 27  ASN A HD21 1 
ATOM   541  H  HD22 . ASN A 1 27  ? 8.93400   -29.72900 -2.51200  1.000 24.16428 ? 27  ASN A HD22 1 
ATOM   542  N  N    . TRP A 1 28  ? 6.00200   -25.85300 -3.42700  1.000 16.89789 ? 28  TRP A N    1 
ATOM   543  C  CA   . TRP A 1 28  ? 5.32300   -24.60200 -3.16900  1.000 16.92907 ? 28  TRP A CA   1 
ATOM   544  C  C    . TRP A 1 28  ? 4.55200   -24.13100 -4.38800  1.000 17.09938 ? 28  TRP A C    1 
ATOM   545  O  O    . TRP A 1 28  ? 3.44200   -23.60900 -4.26800  1.000 17.13626 ? 28  TRP A O    1 
ATOM   546  C  CB   . TRP A 1 28  ? 6.35800   -23.56000 -2.75500  1.000 18.19679 ? 28  TRP A CB   1 
ATOM   547  C  CG   . TRP A 1 28  ? 7.06100   -23.91200 -1.48600  1.000 15.86531 ? 28  TRP A CG   1 
ATOM   548  C  CD1  . TRP A 1 28  ? 8.30100   -24.42800 -1.34200  1.000 19.03161 ? 28  TRP A CD1  1 
ATOM   549  C  CD2  . TRP A 1 28  ? 6.52600   -23.75400 -0.16400  1.000 16.29127 ? 28  TRP A CD2  1 
ATOM   550  N  NE1  . TRP A 1 28  ? 8.57700   -24.60700 -0.00600  1.000 19.36026 ? 28  TRP A NE1  1 
ATOM   551  C  CE2  . TRP A 1 28  ? 7.49800   -24.20700 0.73600   1.000 18.56123 ? 28  TRP A CE2  1 
ATOM   552  C  CE3  . TRP A 1 28  ? 5.31200   -23.25500 0.33900   1.000 19.53617 ? 28  TRP A CE3  1 
ATOM   553  C  CZ2  . TRP A 1 28  ? 7.30200   -24.18300 2.11000   1.000 20.53581 ? 28  TRP A CZ2  1 
ATOM   554  C  CZ3  . TRP A 1 28  ? 5.12600   -23.24800 1.70100   1.000 22.05214 ? 28  TRP A CZ3  1 
ATOM   555  C  CH2  . TRP A 1 28  ? 6.11600   -23.69700 2.57000   1.000 22.87361 ? 28  TRP A CH2  1 
ATOM   556  H  H    . TRP A 1 28  ? 6.85600   -25.77800 -3.49800  1.000 20.28104 ? 28  TRP A H    1 
ATOM   557  H  HA   . TRP A 1 28  ? 4.68700   -24.71900 -2.44700  1.000 20.31845 ? 28  TRP A HA   1 
ATOM   558  H  HB2  . TRP A 1 28  ? 7.02500   -23.48300 -3.45500  1.000 21.83972 ? 28  TRP A HB2  1 
ATOM   559  H  HB3  . TRP A 1 28  ? 5.91300   -22.70800 -2.62500  1.000 21.83972 ? 28  TRP A HB3  1 
ATOM   560  H  HD1  . TRP A 1 28  ? 8.88100   -24.63100 -2.04000  1.000 22.84150 ? 28  TRP A HD1  1 
ATOM   561  H  HE1  . TRP A 1 28  ? 9.31200   -24.92000 0.31300   1.000 23.23588 ? 28  TRP A HE1  1 
ATOM   562  H  HE3  . TRP A 1 28  ? 4.65200   -22.93800 -0.23400  1.000 23.44697 ? 28  TRP A HE3  1 
ATOM   563  H  HZ2  . TRP A 1 28  ? 7.95700   -24.48800 2.69600   1.000 24.64654 ? 28  TRP A HZ2  1 
ATOM   564  H  HZ3  . TRP A 1 28  ? 4.32100   -22.93700 2.04800   1.000 26.46613 ? 28  TRP A HZ3  1 
ATOM   565  H  HH2  . TRP A 1 28  ? 5.96300   -23.66300 3.48700   1.000 27.45190 ? 28  TRP A HH2  1 
ATOM   566  N  N    . VAL A 1 29  ? 5.09700   -24.34700 -5.57600  1.000 16.46959 ? 29  VAL A N    1 
ATOM   567  C  CA   . VAL A 1 29  ? 4.41400   -23.95500 -6.80300  1.000 15.99229 ? 29  VAL A CA   1 
ATOM   568  C  C    . VAL A 1 29  ? 3.18700   -24.83200 -7.00800  1.000 16.70443 ? 29  VAL A C    1 
ATOM   569  O  O    . VAL A 1 29  ? 2.10100   -24.35000 -7.36100  1.000 16.75767 ? 29  VAL A O    1 
ATOM   570  C  CB   . VAL A 1 29  ? 5.38500   -24.01100 -8.00800  1.000 17.93688 ? 29  VAL A CB   1 
ATOM   571  C  CG1  . VAL A 1 29  ? 4.65100   -23.73400 -9.30300  1.000 18.83117 ? 29  VAL A CG1  1 
ATOM   572  C  CG2  . VAL A 1 29  ? 6.52800   -23.01100 -7.81400  1.000 20.26823 ? 29  VAL A CG2  1 
ATOM   573  H  H    . VAL A 1 29  ? 5.86200   -24.71900 -5.70200  1.000 19.76707 ? 29  VAL A H    1 
ATOM   574  H  HA   . VAL A 1 29  ? 4.11600   -23.03500 -6.72200  1.000 19.19432 ? 29  VAL A HA   1 
ATOM   575  H  HB   . VAL A 1 29  ? 5.76300   -24.90200 -8.06300  1.000 21.52783 ? 29  VAL A HB   1 
ATOM   576  H  HG11 . VAL A 1 29  ? 5.30100   -23.58200 -10.00700 1.000 22.60098 ? 29  VAL A HG11 1 
ATOM   577  H  HG12 . VAL A 1 29  ? 4.09900   -24.50100 -9.52200  1.000 22.60098 ? 29  VAL A HG12 1 
ATOM   578  H  HG13 . VAL A 1 29  ? 4.09500   -22.94800 -9.18900  1.000 22.60098 ? 29  VAL A HG13 1 
ATOM   579  H  HG21 . VAL A 1 29  ? 7.22600   -23.20000 -8.46100  1.000 24.32544 ? 29  VAL A HG21 1 
ATOM   580  H  HG22 . VAL A 1 29  ? 6.18800   -22.11200 -7.94800  1.000 24.32544 ? 29  VAL A HG22 1 
ATOM   581  H  HG23 . VAL A 1 29  ? 6.87800   -23.10100 -6.91400  1.000 24.32544 ? 29  VAL A HG23 1 
ATOM   582  N  N    . CYS A 1 30  ? 3.33000   -26.14000 -6.79200  1.000 16.21555 ? 30  CYS A N    1 
ATOM   583  C  CA   . CYS A 1 30  ? 2.20800   -27.05300 -6.89800  1.000 16.12876 ? 30  CYS A CA   1 
ATOM   584  C  C    . CYS A 1 30  ? 1.09400   -26.66900 -5.91200  1.000 15.44190 ? 30  CYS A C    1 
ATOM   585  O  O    . CYS A 1 30  ? -0.08600  -26.62400 -6.27900  1.000 16.05760 ? 30  CYS A O    1 
ATOM   586  C  CB   . CYS A 1 30  ? 2.71600   -28.47600 -6.63600  1.000 17.28500 ? 30  CYS A CB   1 
ATOM   587  S  SG   . CYS A 1 30  ? 1.45400   -29.74400 -6.86300  1.000 17.56268 ? 30  CYS A SG   1 
ATOM   588  H  H    . CYS A 1 30  ? 4.07200   -26.52100 -6.58200  1.000 19.46223 ? 30  CYS A H    1 
ATOM   589  H  HA   . CYS A 1 30  ? 1.82800   -27.01900 -7.79000  1.000 19.35808 ? 30  CYS A HA   1 
ATOM   590  H  HB2  . CYS A 1 30  ? 3.44200   -28.66700 -7.25000  1.000 20.74557 ? 30  CYS A HB2  1 
ATOM   591  H  HB3  . CYS A 1 30  ? 3.03100   -28.53200 -5.72000  1.000 20.74557 ? 30  CYS A HB3  1 
ATOM   592  N  N    . ALA A 1 31  ? 1.47300   -26.35100 -4.67700  1.000 15.37792 ? 31  ALA A N    1 
ATOM   593  C  CA   . ALA A 1 31  ? 0.45700   -25.98600 -3.68400  1.000 16.66599 ? 31  ALA A CA   1 
ATOM   594  C  C    . ALA A 1 31  ? -0.28300  -24.72600 -4.11100  1.000 15.93382 ? 31  ALA A C    1 
ATOM   595  O  O    . ALA A 1 31  ? -1.51200  -24.66900 -4.03600  1.000 17.58474 ? 31  ALA A O    1 
ATOM   596  C  CB   . ALA A 1 31  ? 1.07600   -25.75000 -2.31000  1.000 17.39547 ? 31  ALA A CB   1 
ATOM   597  H  H    . ALA A 1 31  ? 2.28500   -26.33700 -4.39300  1.000 18.45707 ? 31  ALA A H    1 
ATOM   598  H  HA   . ALA A 1 31  ? -0.16300  -26.72900 -3.61000  1.000 20.00275 ? 31  ALA A HA   1 
ATOM   599  H  HB1  . ALA A 1 31  ? 0.38300   -25.46000 -1.69700  1.000 20.87813 ? 31  ALA A HB1  1 
ATOM   600  H  HB2  . ALA A 1 31  ? 1.47100   -26.57800 -1.99500  1.000 20.87813 ? 31  ALA A HB2  1 
ATOM   601  H  HB3  . ALA A 1 31  ? 1.75900   -25.06600 -2.38500  1.000 20.87813 ? 31  ALA A HB3  1 
ATOM   602  N  N    . ALA A 1 32  ? 0.44000   -23.73100 -4.61100  1.000 15.38826 ? 32  ALA A N    1 
ATOM   603  C  CA   . ALA A 1 32  ? -0.19600  -22.48900 -5.04600  1.000 15.34015 ? 32  ALA A CA   1 
ATOM   604  C  C    . ALA A 1 32  ? -1.12500  -22.72000 -6.23100  1.000 16.57021 ? 32  ALA A C    1 
ATOM   605  O  O    . ALA A 1 32  ? -2.21100  -22.12900 -6.30100  1.000 18.59238 ? 32  ALA A O    1 
ATOM   606  C  CB   . ALA A 1 32  ? 0.85900   -21.44600 -5.42100  1.000 17.47796 ? 32  ALA A CB   1 
ATOM   607  H  H    . ALA A 1 32  ? 1.29400   -23.74600 -4.71000  1.000 18.46948 ? 32  ALA A H    1 
ATOM   608  H  HA   . ALA A 1 32  ? -0.71700  -22.14700 -4.30300  1.000 18.41175 ? 32  ALA A HA   1 
ATOM   609  H  HB1  . ALA A 1 32  ? 0.41700   -20.67600 -5.81200  1.000 20.97712 ? 32  ALA A HB1  1 
ATOM   610  H  HB2  . ALA A 1 32  ? 1.34000   -21.18100 -4.62100  1.000 20.97712 ? 32  ALA A HB2  1 
ATOM   611  H  HB3  . ALA A 1 32  ? 1.47400   -21.83600 -6.06200  1.000 20.97712 ? 32  ALA A HB3  1 
ATOM   612  N  N    . LYS A 1 33  ? -0.73800  -23.57300 -7.18100  1.000 15.66401 ? 33  LYS A N    1 
ATOM   613  C  CA   . LYS A 1 33  ? -1.59000  -23.85100 -8.32000  1.000 16.70749 ? 33  LYS A CA   1 
ATOM   614  C  C    . LYS A 1 33  ? -2.93600  -24.38400 -7.86200  1.000 16.31398 ? 33  LYS A C    1 
ATOM   615  O  O    . LYS A 1 33  ? -3.99500  -23.90000 -8.28500  1.000 18.12148 ? 33  LYS A O    1 
ATOM   616  C  CB   . LYS A 1 33  ? -0.93200  -24.91300 -9.20700  1.000 21.52431 ? 33  LYS A CB   1 
ATOM   617  C  CG   . LYS A 1 33  ? -1.85600  -25.45000 -10.29400 1.000 23.42375 ? 33  LYS A CG   1 
ATOM   618  C  CD   . LYS A 1 33  ? -2.09900  -24.45700 -11.38400 1.000 28.19028 ? 33  LYS A CD   1 
ATOM   619  C  CE   . LYS A 1 33  ? -3.13500  -24.97200 -12.38300 1.000 44.17582 ? 33  LYS A CE   1 
ATOM   620  N  NZ   . LYS A 1 33  ? -3.38600  -23.97100 -13.46000 1.000 43.04315 ? 33  LYS A NZ   1 
ATOM   621  H  H    . LYS A 1 33  ? 0.00900   -23.99800 -7.18400  1.000 18.80038 ? 33  LYS A H    1 
ATOM   622  H  HA   . LYS A 1 33  ? -1.71200  -23.03100 -8.82200  1.000 20.05255 ? 33  LYS A HA   1 
ATOM   623  H  HB2  . LYS A 1 33  ? -0.15800  -24.52200 -9.64100  1.000 25.83274 ? 33  LYS A HB2  1 
ATOM   624  H  HB3  . LYS A 1 33  ? -0.66000  -25.66000 -8.65200  1.000 25.83274 ? 33  LYS A HB3  1 
ATOM   625  H  HG2  . LYS A 1 33  ? -1.45400  -26.23900 -10.69100 1.000 28.11207 ? 33  LYS A HG2  1 
ATOM   626  H  HG3  . LYS A 1 33  ? -2.71200  -25.67800 -9.89800  1.000 28.11207 ? 33  LYS A HG3  1 
ATOM   627  H  HD2  . LYS A 1 33  ? -2.43100  -23.63100 -10.99800 1.000 33.83190 ? 33  LYS A HD2  1 
ATOM   628  H  HD3  . LYS A 1 33  ? -1.27100  -24.29200 -11.86000 1.000 33.83190 ? 33  LYS A HD3  1 
ATOM   629  H  HE2  . LYS A 1 33  ? -2.81000  -25.78800 -12.79400 1.000 53.01455 ? 33  LYS A HE2  1 
ATOM   630  H  HE3  . LYS A 1 33  ? -3.97100  -25.14300 -11.92300 1.000 53.01455 ? 33  LYS A HE3  1 
ATOM   631  H  HZ1  . LYS A 1 33  ? -3.68000  -23.21000 -13.10500 1.000 51.65535 ? 33  LYS A HZ1  1 
ATOM   632  H  HZ2  . LYS A 1 33  ? -2.63400  -23.81000 -13.90700 1.000 51.65535 ? 33  LYS A HZ2  1 
ATOM   633  H  HZ3  . LYS A 1 33  ? -3.99800  -24.28100 -14.02700 1.000 51.65535 ? 33  LYS A HZ3  1 
ATOM   634  N  N    . PHE A 1 34  ? -2.92700  -25.38700 -6.97700  1.000 16.70698 ? 34  PHE A N    1 
ATOM   635  C  CA   . PHE A 1 34  ? -4.18100  -26.00900 -6.61000  1.000 17.12917 ? 34  PHE A CA   1 
ATOM   636  C  C    . PHE A 1 34  ? -4.91500  -25.29100 -5.49400  1.000 17.08043 ? 34  PHE A C    1 
ATOM   637  O  O    . PHE A 1 34  ? -6.14200  -25.45000 -5.39600  1.000 22.05849 ? 34  PHE A O    1 
ATOM   638  C  CB   . PHE A 1 34  ? -3.96700  -27.47700 -6.30000  1.000 17.12787 ? 34  PHE A CB   1 
ATOM   639  C  CG   . PHE A 1 34  ? -3.51000  -28.26500 -7.49600  1.000 17.50368 ? 34  PHE A CG   1 
ATOM   640  C  CD1  . PHE A 1 34  ? -4.24100  -28.25500 -8.65400  1.000 19.01546 ? 34  PHE A CD1  1 
ATOM   641  C  CD2  . PHE A 1 34  ? -2.31700  -28.94700 -7.48100  1.000 21.82204 ? 34  PHE A CD2  1 
ATOM   642  C  CE1  . PHE A 1 34  ? -3.81500  -28.94200 -9.74900  1.000 23.13276 ? 34  PHE A CE1  1 
ATOM   643  C  CE2  . PHE A 1 34  ? -1.90500  -29.66200 -8.58900  1.000 28.14275 ? 34  PHE A CE2  1 
ATOM   644  C  CZ   . PHE A 1 34  ? -2.64200  -29.64100 -9.70500  1.000 23.59233 ? 34  PHE A CZ   1 
ATOM   645  H  H    . PHE A 1 34  ? -2.22600  -25.70600 -6.59400  1.000 20.05195 ? 34  PHE A H    1 
ATOM   646  H  HA   . PHE A 1 34  ? -4.78400  -25.98400 -7.36900  1.000 20.55857 ? 34  PHE A HA   1 
ATOM   647  H  HB2  . PHE A 1 34  ? -3.28900  -27.55800 -5.61100  1.000 20.55701 ? 34  PHE A HB2  1 
ATOM   648  H  HB3  . PHE A 1 34  ? -4.80300  -27.85900 -5.99000  1.000 20.55701 ? 34  PHE A HB3  1 
ATOM   649  H  HD1  . PHE A 1 34  ? -5.03700  -27.77500 -8.69200  1.000 22.82213 ? 34  PHE A HD1  1 
ATOM   650  H  HD2  . PHE A 1 34  ? -1.78300  -28.92700 -6.71900  1.000 26.19002 ? 34  PHE A HD2  1 
ATOM   651  H  HE1  . PHE A 1 34  ? -4.32200  -28.93500 -10.52800 1.000 27.76289 ? 34  PHE A HE1  1 
ATOM   652  H  HE2  . PHE A 1 34  ? -1.11800  -30.15700 -8.55900  1.000 33.77487 ? 34  PHE A HE2  1 
ATOM   653  H  HZ   . PHE A 1 34  ? -2.35300  -30.10500 -10.45700 1.000 28.31436 ? 34  PHE A HZ   1 
ATOM   654  N  N    . GLU A 1 35  ? -4.24600  -24.48100 -4.68900  1.000 15.50017 ? 35  GLU A N    1 
ATOM   655  C  CA   . GLU A 1 35  ? -4.96500  -23.67100 -3.68900  1.000 15.60637 ? 35  GLU A CA   1 
ATOM   656  C  C    . GLU A 1 35  ? -5.67500  -22.47200 -4.31600  1.000 17.76629 ? 35  GLU A C    1 
ATOM   657  O  O    . GLU A 1 35  ? -6.81000  -22.16300 -3.94700  1.000 18.97934 ? 35  GLU A O    1 
ATOM   658  C  CB   . GLU A 1 35  ? -4.00400  -23.21500 -2.59200  1.000 16.62200 ? 35  GLU A CB   1 
ATOM   659  C  CG   . GLU A 1 35  ? -3.50100  -24.34500 -1.72500  1.000 17.55798 ? 35  GLU A CG   1 
ATOM   660  C  CD   . GLU A 1 35  ? -4.54600  -24.84300 -0.75600  1.000 20.25264 ? 35  GLU A CD   1 
ATOM   661  O  OE1  . GLU A 1 35  ? -5.67900  -24.30400 -0.70800  1.000 22.27134 ? 35  GLU A OE1  1 
ATOM   662  O  OE2  . GLU A 1 35  ? -4.28800  -25.89800 -0.13700  1.000 21.00621 ? 35  GLU A OE2  1 
ATOM   663  H  H    . GLU A 1 35  ? -3.39200  -24.37500 -4.69300  1.000 18.60377 ? 35  GLU A H    1 
ATOM   664  H  HA   . GLU A 1 35  ? -5.64600  -24.22900 -3.28000  1.000 18.73121 ? 35  GLU A HA   1 
ATOM   665  H  HB2  . GLU A 1 35  ? -3.23600  -22.79200 -3.00500  1.000 19.94996 ? 35  GLU A HB2  1 
ATOM   666  H  HB3  . GLU A 1 35  ? -4.46300  -22.58200 -2.01700  1.000 19.94996 ? 35  GLU A HB3  1 
ATOM   667  H  HG2  . GLU A 1 35  ? -3.24000  -25.08700 -2.29300  1.000 21.07315 ? 35  GLU A HG2  1 
ATOM   668  H  HG3  . GLU A 1 35  ? -2.73800  -24.03600 -1.21300  1.000 21.07315 ? 35  GLU A HG3  1 
ATOM   669  N  N    . SER A 1 36  ? -5.04800  -21.78900 -5.26500  1.000 16.30340 ? 36  SER A N    1 
ATOM   670  C  CA   . SER A 1 36  ? -5.51000  -20.48000 -5.71800  1.000 16.25129 ? 36  SER A CA   1 
ATOM   671  C  C    . SER A 1 36  ? -5.47500  -20.29300 -7.22500  1.000 18.16554 ? 36  SER A C    1 
ATOM   672  O  O    . SER A 1 36  ? -5.83700  -19.19900 -7.68400  1.000 18.63086 ? 36  SER A O    1 
ATOM   673  C  CB   . SER A 1 36  ? -4.65200  -19.38600 -5.10500  1.000 18.10119 ? 36  SER A CB   1 
ATOM   674  O  OG   . SER A 1 36  ? -3.35000  -19.38900 -5.68100  1.000 17.53192 ? 36  SER A OG   1 
ATOM   675  H  H    . SER A 1 36  ? -4.34100  -22.06500 -5.67100  1.000 19.56765 ? 36  SER A H    1 
ATOM   676  H  HA   . SER A 1 36  ? -6.42800  -20.37600 -5.42300  1.000 19.50511 ? 36  SER A HA   1 
ATOM   677  H  HB2  . SER A 1 36  ? -5.07000  -18.52700 -5.27000  1.000 21.72500 ? 36  SER A HB2  1 
ATOM   678  H  HB3  . SER A 1 36  ? -4.57600  -19.54100 -4.15000  1.000 21.72500 ? 36  SER A HB3  1 
ATOM   679  H  HG   . SER A 1 36  ? -2.95800  -20.10900 -5.50100  1.000 21.04187 ? 36  SER A HG   1 
ATOM   680  N  N    . ASN A 1 37  ? -5.00900  -21.27400 -8.00700  1.000 18.23689 ? 37  ASN A N    1 
ATOM   681  C  CA   . ASN A 1 37  ? -4.80400  -21.11400 -9.44500  1.000 18.64150 ? 37  ASN A CA   1 
ATOM   682  C  C    . ASN A 1 37  ? -3.87000  -19.94800 -9.73400  1.000 17.94953 ? 37  ASN A C    1 
ATOM   683  O  O    . ASN A 1 37  ? -4.00300  -19.25500 -10.74600 1.000 21.44373 ? 37  ASN A O    1 
ATOM   684  C  CB   . ASN A 1 37  ? -6.11900  -21.00700 -10.22100 1.000 22.16707 ? 37  ASN A CB   1 
ATOM   685  C  CG   . ASN A 1 37  ? -6.03100  -21.63300 -11.56800 1.000 38.91856 ? 37  ASN A CG   1 
ATOM   686  O  OD1  . ASN A 1 37  ? -5.00000  -22.18500 -11.93700 1.000 33.06430 ? 37  ASN A OD1  1 
ATOM   687  N  ND2  . ASN A 1 37  ? -7.12700  -21.58300 -12.31200 1.000 68.06421 ? 37  ASN A ND2  1 
ATOM   688  H  H    . ASN A 1 37  ? -4.80000  -22.05700 -7.71800  1.000 21.88783 ? 37  ASN A H    1 
ATOM   689  H  HA   . ASN A 1 37  ? -4.37500  -21.91600 -9.78300  1.000 22.37336 ? 37  ASN A HA   1 
ATOM   690  H  HB2  . ASN A 1 37  ? -6.82000  -21.45700 -9.72400  1.000 26.60406 ? 37  ASN A HB2  1 
ATOM   691  H  HB3  . ASN A 1 37  ? -6.34300  -20.07000 -10.33800 1.000 26.60406 ? 37  ASN A HB3  1 
ATOM   692  H  HD21 . ASN A 1 37  ? -7.83600  -21.20400 -12.00800 1.000 81.68062 ? 37  ASN A HD21 1 
ATOM   693  H  HD22 . ASN A 1 37  ? -7.12900  -21.93100 -13.09900 1.000 81.68062 ? 37  ASN A HD22 1 
ATOM   694  N  N    . PHE A 1 38  ? -2.92000  -19.70400 -8.83700  1.000 17.07745 ? 38  PHE A N    1 
ATOM   695  C  CA   . PHE A 1 38  ? -1.89500  -18.67400 -8.94800  1.000 17.82697 ? 38  PHE A CA   1 
ATOM   696  C  C    . PHE A 1 38  ? -2.44700  -17.24900 -8.83500  1.000 17.77319 ? 38  PHE A C    1 
ATOM   697  O  O    . PHE A 1 38  ? -1.79400  -16.29000 -9.23100  1.000 20.16340 ? 38  PHE A O    1 
ATOM   698  C  CB   . PHE A 1 38  ? -1.06300  -18.78700 -10.23500 1.000 19.21926 ? 38  PHE A CB   1 
ATOM   699  C  CG   . PHE A 1 38  ? -0.28700  -20.08400 -10.41600 1.000 18.58830 ? 38  PHE A CG   1 
ATOM   700  C  CD1  . PHE A 1 38  ? 0.33500   -20.72700 -9.37500  1.000 19.69395 ? 38  PHE A CD1  1 
ATOM   701  C  CD2  . PHE A 1 38  ? -0.14000  -20.60100 -11.68400 1.000 21.41325 ? 38  PHE A CD2  1 
ATOM   702  C  CE1  . PHE A 1 38  ? 1.09000   -21.88200 -9.59400  1.000 20.22267 ? 38  PHE A CE1  1 
ATOM   703  C  CE2  . PHE A 1 38  ? 0.62300   -21.75100 -11.91100 1.000 22.27819 ? 38  PHE A CE2  1 
ATOM   704  C  CZ   . PHE A 1 38  ? 1.20700   -22.38100 -10.87400 1.000 21.00599 ? 38  PHE A CZ   1 
ATOM   705  H  H    . PHE A 1 38  ? -2.84500  -20.15200 -8.10700  1.000 20.49651 ? 38  PHE A H    1 
ATOM   706  H  HA   . PHE A 1 38  ? -1.29700  -18.82200 -8.20000  1.000 21.39594 ? 38  PHE A HA   1 
ATOM   707  H  HB2  . PHE A 1 38  ? -1.66400  -18.70400 -10.99200 1.000 23.06669 ? 38  PHE A HB2  1 
ATOM   708  H  HB3  . PHE A 1 38  ? -0.41800  -18.06300 -10.24200 1.000 23.06669 ? 38  PHE A HB3  1 
ATOM   709  H  HD1  . PHE A 1 38  ? 0.25300   -20.39000 -8.51300  1.000 23.63630 ? 38  PHE A HD1  1 
ATOM   710  H  HD2  . PHE A 1 38  ? -0.55500  -20.17800 -12.40000 1.000 25.69947 ? 38  PHE A HD2  1 
ATOM   711  H  HE1  . PHE A 1 38  ? 1.51000   -22.31000 -8.88400  1.000 24.27077 ? 38  PHE A HE1  1 
ATOM   712  H  HE2  . PHE A 1 38  ? 0.72600   -22.07900 -12.77500 1.000 26.73740 ? 38  PHE A HE2  1 
ATOM   713  H  HZ   . PHE A 1 38  ? 1.69400   -23.15900 -11.02300 1.000 25.21076 ? 38  PHE A HZ   1 
ATOM   714  N  N    . ASN A 1 39  ? -3.63700  -17.08800 -8.25800  1.000 18.32275 ? 39  ASN A N    1 
ATOM   715  C  CA   . ASN A 1 39  ? -4.30200  -15.78100 -8.15700  1.000 17.49852 ? 39  ASN A CA   1 
ATOM   716  C  C    . ASN A 1 39  ? -4.14800  -15.24100 -6.74400  1.000 16.09643 ? 39  ASN A C    1 
ATOM   717  O  O    . ASN A 1 39  ? -4.69300  -15.82700 -5.79000  1.000 18.43118 ? 39  ASN A O    1 
ATOM   718  C  CB   . ASN A 1 39  ? -5.77400  -15.95900 -8.50000  1.000 18.07301 ? 39  ASN A CB   1 
ATOM   719  C  CG   . ASN A 1 39  ? -6.55100  -14.67900 -8.48400  1.000 18.80106 ? 39  ASN A CG   1 
ATOM   720  O  OD1  . ASN A 1 39  ? -6.03200  -13.62500 -8.27200  1.000 19.09981 ? 39  ASN A OD1  1 
ATOM   721  N  ND2  . ASN A 1 39  ? -7.82500  -14.79700 -8.76400  1.000 23.92088 ? 39  ASN A ND2  1 
ATOM   722  H  H    . ASN A 1 39  ? -4.09100  -17.73000 -7.91100  1.000 21.99087 ? 39  ASN A H    1 
ATOM   723  H  HA   . ASN A 1 39  ? -3.89200  -15.14000 -8.76000  1.000 21.00180 ? 39  ASN A HA   1 
ATOM   724  H  HB2  . ASN A 1 39  ? -5.84400  -16.33800 -9.39000  1.000 21.69118 ? 39  ASN A HB2  1 
ATOM   725  H  HB3  . ASN A 1 39  ? -6.17600  -16.55900 -7.85200  1.000 21.69118 ? 39  ASN A HB3  1 
ATOM   726  H  HD21 . ASN A 1 39  ? -8.32900  -14.10100 -8.77300  1.000 28.70862 ? 39  ASN A HD21 1 
ATOM   727  H  HD22 . ASN A 1 39  ? -8.15700  -15.57100 -8.93900  1.000 28.70862 ? 39  ASN A HD22 1 
ATOM   728  N  N    . THR A 1 40  ? -3.46000  -14.10900 -6.59100  1.000 16.87758 ? 40  THR A N    1 
ATOM   729  C  CA   . THR A 1 40  ? -3.25700  -13.54400 -5.26900  1.000 17.33437 ? 40  THR A CA   1 
ATOM   730  C  C    . THR A 1 40  ? -4.57500  -13.08900 -4.62500  1.000 18.02253 ? 40  THR A C    1 
ATOM   731  O  O    . THR A 1 40  ? -4.62600  -12.96200 -3.41200  1.000 18.72941 ? 40  THR A O    1 
ATOM   732  C  CB   . THR A 1 40  ? -2.30000  -12.35500 -5.26800  1.000 19.44724 ? 40  THR A CB   1 
ATOM   733  O  OG1  . THR A 1 40  ? -2.89900  -11.27900 -6.00100  1.000 20.03383 ? 40  THR A OG1  1 
ATOM   734  C  CG2  . THR A 1 40  ? -0.91300  -12.69300 -5.83800  1.000 19.18471 ? 40  THR A CG2  1 
ATOM   735  H  H    . THR A 1 40  ? -3.10700  -13.65800 -7.23200  1.000 20.25666 ? 40  THR A H    1 
ATOM   736  H  HA   . THR A 1 40  ? -2.84500  -14.24400 -4.73900  1.000 20.80481 ? 40  THR A HA   1 
ATOM   737  H  HB   . THR A 1 40  ? -2.14100  -12.08500 -4.35000  1.000 23.34025 ? 40  THR A HB   1 
ATOM   738  H  HG1  . THR A 1 40  ? -2.60200  -10.54300 -5.72600  1.000 24.04417 ? 40  THR A HG1  1 
ATOM   739  H  HG21 . THR A 1 40  ? -0.28400  -11.98700 -5.61900  1.000 23.02522 ? 40  THR A HG21 1 
ATOM   740  H  HG22 . THR A 1 40  ? -0.59400  -13.52700 -5.46100  1.000 23.02522 ? 40  THR A HG22 1 
ATOM   741  H  HG23 . THR A 1 40  ? -0.96400  -12.78200 -6.80200  1.000 23.02522 ? 40  THR A HG23 1 
ATOM   742  N  N    A GLN A 1 41  ? -5.61700  -12.85500 -5.41400  0.520 16.26447 ? 41  GLN A N    1 
ATOM   743  N  N    B GLN A 1 41  ? -5.62500  -12.82700 -5.39800  0.480 16.23388 ? 41  GLN A N    1 
ATOM   744  C  CA   A GLN A 1 41  ? -6.86400  -12.31600 -4.88500  0.520 16.14933 ? 41  GLN A CA   1 
ATOM   745  C  CA   B GLN A 1 41  ? -6.87700  -12.31300 -4.83200  0.480 16.10997 ? 41  GLN A CA   1 
ATOM   746  C  C    A GLN A 1 41  ? -7.81800  -13.37400 -4.36200  0.520 17.08711 ? 41  GLN A C    1 
ATOM   747  C  C    B GLN A 1 41  ? -7.90100  -13.40800 -4.51900  0.480 18.28420 ? 41  GLN A C    1 
ATOM   748  O  O    A GLN A 1 41  ? -8.86400  -13.00200 -3.80100  0.520 17.52536 ? 41  GLN A O    1 
ATOM   749  O  O    B GLN A 1 41  ? -9.08300  -13.11300 -4.27500  0.480 18.81391 ? 41  GLN A O    1 
ATOM   750  C  CB   A GLN A 1 41  ? -7.59600  -11.50400 -5.95800  0.520 18.00580 ? 41  GLN A CB   1 
ATOM   751  C  CB   B GLN A 1 41  ? -7.47800  -11.23400 -5.74500  0.480 15.94881 ? 41  GLN A CB   1 
ATOM   752  C  CG   A GLN A 1 41  ? -6.84100  -10.27200 -6.41200  0.520 17.68820 ? 41  GLN A CG   1 
ATOM   753  C  CG   B GLN A 1 41  ? -6.55900  -10.05100 -6.03400  0.480 19.43356 ? 41  GLN A CG   1 
ATOM   754  C  CD   A GLN A 1 41  ? -7.73700  -9.23900  -7.07700  0.520 17.84285 ? 41  GLN A CD   1 
ATOM   755  C  CD   B GLN A 1 41  ? -7.28200  -8.90500  -6.72000  0.480 16.80894 ? 41  GLN A CD   1 
ATOM   756  O  OE1  A GLN A 1 41  ? -8.61900  -8.66500  -6.43500  0.520 17.04106 ? 41  GLN A OE1  1 
ATOM   757  O  OE1  B GLN A 1 41  ? -7.92700  -8.10300  -6.07100  0.480 21.31620 ? 41  GLN A OE1  1 
ATOM   758  N  NE2  A GLN A 1 41  ? -7.52900  -9.02700  -8.36800  0.520 22.06737 ? 41  GLN A NE2  1 
ATOM   759  N  NE2  B GLN A 1 41  ? -7.19300  -8.85200  -8.03900  0.480 16.90037 ? 41  GLN A NE2  1 
ATOM   760  H  H    A GLN A 1 41  ? -5.62700  -13.00100 -6.26200  0.520 19.52093 ? 41  GLN A H    1 
ATOM   761  H  H    B GLN A 1 41  ? -5.64000  -12.93700 -6.25100  0.480 19.48422 ? 41  GLN A H    1 
ATOM   762  H  HA   A GLN A 1 41  ? -6.63400  -11.72600 -4.15000  0.520 19.38277 ? 41  GLN A HA   1 
ATOM   763  H  HA   B GLN A 1 41  ? -6.67300  -11.88200 -3.98800  0.480 19.33554 ? 41  GLN A HA   1 
ATOM   764  H  HB2  A GLN A 1 41  ? -7.73600  -12.06900 -6.73500  0.520 21.61053 ? 41  GLN A HB2  1 
ATOM   765  H  HB2  B GLN A 1 41  ? -7.70300  -11.64200 -6.59600  0.480 19.14214 ? 41  GLN A HB2  1 
ATOM   766  H  HB3  A GLN A 1 41  ? -8.45000  -11.21400 -5.60100  0.520 21.61053 ? 41  GLN A HB3  1 
ATOM   767  H  HB3  B GLN A 1 41  ? -8.27800  -10.88500 -5.32300  0.480 19.14214 ? 41  GLN A HB3  1 
ATOM   768  H  HG2  A GLN A 1 41  ? -6.42500  -9.85500  -5.64100  0.520 21.22941 ? 41  GLN A HG2  1 
ATOM   769  H  HG2  B GLN A 1 41  ? -6.19600  -9.72000  -5.19800  0.480 23.32384 ? 41  GLN A HG2  1 
ATOM   770  H  HG3  A GLN A 1 41  ? -6.16200  -10.53600 -7.05300  0.520 21.22941 ? 41  GLN A HG3  1 
ATOM   771  H  HG3  B GLN A 1 41  ? -5.83900  -10.34300 -6.61500  0.480 23.32384 ? 41  GLN A HG3  1 
ATOM   772  H  HE21 A GLN A 1 41  ? -8.00900  -8.45300  -8.79200  0.520 26.48442 ? 41  GLN A HE21 1 
ATOM   773  H  HE21 B GLN A 1 41  ? -7.58600  -8.22100  -8.47100  0.480 20.28402 ? 41  GLN A HE21 1 
ATOM   774  H  HE22 A GLN A 1 41  ? -6.91500  -9.46400  -8.78200  0.520 26.48442 ? 41  GLN A HE22 1 
ATOM   775  H  HE22 B GLN A 1 41  ? -6.74200  -9.44900  -8.46300  0.480 20.28402 ? 41  GLN A HE22 1 
ATOM   776  N  N    . ALA A 1 42  ? -7.50000  -14.66900 -4.53000  1.000 16.37456 ? 42  ALA A N    1 
ATOM   777  C  CA   . ALA A 1 42  ? -8.42800  -15.74100 -4.22000  1.000 17.92977 ? 42  ALA A CA   1 
ATOM   778  C  C    . ALA A 1 42  ? -8.87100  -15.71000 -2.76600  1.000 15.45573 ? 42  ALA A C    1 
ATOM   779  O  O    . ALA A 1 42  ? -8.06100  -15.58700 -1.85100  1.000 17.99244 ? 42  ALA A O    1 
ATOM   780  C  CB   . ALA A 1 42  ? -7.78700  -17.09800 -4.53800  1.000 21.52674 ? 42  ALA A CB   1 
ATOM   781  H  H    . ALA A 1 42  ? -6.74200  -14.94500 -4.82700  1.000 19.65304 ? 42  ALA A H    1 
ATOM   782  H  HA   . ALA A 1 42  ? -9.22200  -15.62800 -4.76600  1.000 21.51929 ? 42  ALA A HA   1 
ATOM   783  H  HB1  . ALA A 1 42  ? -8.43700  -17.80000 -4.37700  1.000 25.83566 ? 42  ALA A HB1  1 
ATOM   784  H  HB2  . ALA A 1 42  ? -7.51500  -17.10800 -5.46900  1.000 25.83566 ? 42  ALA A HB2  1 
ATOM   785  H  HB3  . ALA A 1 42  ? -7.01400  -17.22400 -3.96600  1.000 25.83566 ? 42  ALA A HB3  1 
ATOM   786  N  N    . THR A 1 43  ? -10.16800 -15.90700 -2.56300  1.000 16.37124 ? 43  THR A N    1 
ATOM   787  C  CA   . THR A 1 43  ? -10.74500 -16.06800 -1.23700  1.000 17.39977 ? 43  THR A CA   1 
ATOM   788  C  C    . THR A 1 43  ? -11.75500 -17.19600 -1.27100  1.000 19.46854 ? 43  THR A C    1 
ATOM   789  O  O    . THR A 1 43  ? -12.45200 -17.39400 -2.26300  1.000 22.91864 ? 43  THR A O    1 
ATOM   790  C  CB   . THR A 1 43  ? -11.43800 -14.80500 -0.71800  1.000 19.77308 ? 43  THR A CB   1 
ATOM   791  O  OG1  . THR A 1 43  ? -12.51200 -14.44600 -1.59800  1.000 20.16211 ? 43  THR A OG1  1 
ATOM   792  C  CG2  . THR A 1 43  ? -10.49700 -13.64900 -0.58600  1.000 21.09301 ? 43  THR A CG2  1 
ATOM   793  H  H    . THR A 1 43  ? -10.74900 -15.95200 -3.19600  1.000 19.64905 ? 43  THR A H    1 
ATOM   794  H  HA   . THR A 1 43  ? -10.02800 -16.28500 -0.62100  1.000 20.88329 ? 43  THR A HA   1 
ATOM   795  H  HB   . THR A 1 43  ? -11.78400 -14.99300 0.16900   1.000 23.73126 ? 43  THR A HB   1 
ATOM   796  H  HG1  . THR A 1 43  ? -12.78100 -13.67000 -1.42100  1.000 24.19810 ? 43  THR A HG1  1 
ATOM   797  H  HG21 . THR A 1 43  ? -10.95700 -12.88900 -0.19600  1.000 25.31518 ? 43  THR A HG21 1 
ATOM   798  H  HG22 . THR A 1 43  ? -9.75100  -13.89200 -0.01500  1.000 25.31518 ? 43  THR A HG22 1 
ATOM   799  H  HG23 . THR A 1 43  ? -10.15600 -13.39700 -1.45800  1.000 25.31518 ? 43  THR A HG23 1 
ATOM   800  N  N    A ASN A 1 44  ? -11.88400 -17.91300 -0.15700  0.680 17.89902 ? 44  ASN A N    1 
ATOM   801  N  N    B ASN A 1 44  ? -11.81200 -17.96600 -0.18800  0.320 18.09881 ? 44  ASN A N    1 
ATOM   802  C  CA   A ASN A 1 44  ? -12.87600 -18.97900 -0.07700  0.680 19.36174 ? 44  ASN A CA   1 
ATOM   803  C  CA   B ASN A 1 44  ? -12.80000 -19.02400 -0.03500  0.320 19.72991 ? 44  ASN A CA   1 
ATOM   804  C  C    A ASN A 1 44  ? -13.31600 -19.16200 1.36400   0.680 17.77078 ? 44  ASN A C    1 
ATOM   805  C  C    B ASN A 1 44  ? -13.28100 -19.01300 1.40600   0.320 17.66702 ? 44  ASN A C    1 
ATOM   806  O  O    A ASN A 1 44  ? -12.47800 -19.34700 2.24600   0.680 18.27390 ? 44  ASN A O    1 
ATOM   807  O  O    B ASN A 1 44  ? -12.49000 -18.80100 2.32400   0.320 18.12522 ? 44  ASN A O    1 
ATOM   808  C  CB   A ASN A 1 44  ? -12.29400 -20.30500 -0.57600  0.680 21.15188 ? 44  ASN A CB   1 
ATOM   809  C  CB   B ASN A 1 44  ? -12.20000 -20.40400 -0.35000  0.320 22.12953 ? 44  ASN A CB   1 
ATOM   810  C  CG   A ASN A 1 44  ? -12.10500 -20.32900 -2.06200  0.680 23.55667 ? 44  ASN A CG   1 
ATOM   811  C  CG   B ASN A 1 44  ? -13.22900 -21.37600 -0.92200  0.320 30.26308 ? 44  ASN A CG   1 
ATOM   812  O  OD1  A ASN A 1 44  ? -13.06700 -20.37900 -2.82100  0.680 25.04359 ? 44  ASN A OD1  1 
ATOM   813  O  OD1  B ASN A 1 44  ? -14.04100 -21.94000 -0.19400  0.320 36.82141 ? 44  ASN A OD1  1 
ATOM   814  N  ND2  A ASN A 1 44  ? -10.85800 -20.28600 -2.49400  0.680 26.66032 ? 44  ASN A ND2  1 
ATOM   815  N  ND2  B ASN A 1 44  ? -13.18600 -21.57700 -2.23100  0.320 34.72302 ? 44  ASN A ND2  1 
ATOM   816  H  H    A ASN A 1 44  ? -11.41600 -17.80200 0.55600   0.680 21.48239 ? 44  ASN A H    1 
ATOM   817  H  H    B ASN A 1 44  ? -11.27800 -17.89200 0.48300   0.320 21.72214 ? 44  ASN A H    1 
ATOM   818  H  HA   A ASN A 1 44  ? -13.64400 -18.72800 -0.61400  0.680 23.23766 ? 44  ASN A HA   1 
ATOM   819  H  HA   B ASN A 1 44  ? -13.54700 -18.86900 -0.63400  0.320 23.67946 ? 44  ASN A HA   1 
ATOM   820  H  HB2  A ASN A 1 44  ? -11.42900 -20.44700 -0.16100  0.680 25.38582 ? 44  ASN A HB2  1 
ATOM   821  H  HB2  B ASN A 1 44  ? -11.49100 -20.29900 -1.00200  0.320 26.55900 ? 44  ASN A HB2  1 
ATOM   822  H  HB3  A ASN A 1 44  ? -12.89900 -21.02500 -0.33900  0.680 25.38582 ? 44  ASN A HB3  1 
ATOM   823  H  HB3  B ASN A 1 44  ? -11.84600 -20.78900 0.46700   0.320 26.55900 ? 44  ASN A HB3  1 
ATOM   824  H  HD21 A ASN A 1 44  ? -10.21000 -20.24700 -1.93000  0.680 31.99595 ? 44  ASN A HD21 1 
ATOM   825  H  HD21 B ASN A 1 44  ? -12.59900 -21.17000 -2.70900  0.320 41.67119 ? 44  ASN A HD21 1 
ATOM   826  H  HD22 A ASN A 1 44  ? -10.69500 -20.29800 -3.33800  0.680 31.99595 ? 44  ASN A HD22 1 
ATOM   827  H  HD22 B ASN A 1 44  ? -13.74400 -22.11600 -2.60200  0.320 41.67119 ? 44  ASN A HD22 1 
ATOM   828  N  N    A ARG A 1 45  ? -14.63600 -19.14700 1.58100   0.680 19.30168 ? 45  ARG A N    1 
ATOM   829  N  N    B ARG A 1 45  ? -14.57900 -19.22800 1.60400   0.320 19.55667 ? 45  ARG A N    1 
ATOM   830  C  CA   A ARG A 1 45  ? -15.19400 -19.28800 2.91600   0.680 21.70055 ? 45  ARG A CA   1 
ATOM   831  C  CA   B ARG A 1 45  ? -15.13400 -19.27300 2.94500   0.320 21.87346 ? 45  ARG A CA   1 
ATOM   832  C  C    A ARG A 1 45  ? -15.27400 -20.75900 3.30700   0.680 24.82743 ? 45  ARG A C    1 
ATOM   833  C  C    B ARG A 1 45  ? -15.40400 -20.71100 3.35100   0.320 24.52873 ? 45  ARG A C    1 
ATOM   834  O  O    A ARG A 1 45  ? -15.53200 -21.63400 2.47300   0.680 27.77789 ? 45  ARG A O    1 
ATOM   835  O  O    B ARG A 1 45  ? -15.98900 -21.48700 2.58700   0.320 22.68701 ? 45  ARG A O    1 
ATOM   836  C  CB   A ARG A 1 45  ? -16.58400 -18.66200 2.96800   0.680 25.42477 ? 45  ARG A CB   1 
ATOM   837  C  CB   B ARG A 1 45  ? -16.43000 -18.48500 3.07600   0.320 25.37945 ? 45  ARG A CB   1 
ATOM   838  C  CG   A ARG A 1 45  ? -17.14400 -18.62200 4.37300   0.680 28.79737 ? 45  ARG A CG   1 
ATOM   839  C  CG   B ARG A 1 45  ? -16.89500 -18.43200 4.52900   0.320 28.68814 ? 45  ARG A CG   1 
ATOM   840  C  CD   A ARG A 1 45  ? -16.76700 -17.34000 5.06000   0.680 29.51716 ? 45  ARG A CD   1 
ATOM   841  C  CD   B ARG A 1 45  ? -17.39900 -17.07000 4.83400   0.320 36.58301 ? 45  ARG A CD   1 
ATOM   842  N  NE   A ARG A 1 45  ? -17.84100 -16.37200 4.89000   0.680 47.40304 ? 45  ARG A NE   1 
ATOM   843  N  NE   B ARG A 1 45  ? -18.39000 -16.71800 3.83100   0.320 40.44116 ? 45  ARG A NE   1 
ATOM   844  C  CZ   A ARG A 1 45  ? -18.45200 -15.73100 5.87700   0.680 35.11858 ? 45  ARG A CZ   1 
ATOM   845  C  CZ   B ARG A 1 45  ? -18.66000 -15.48400 3.44100   0.320 27.57832 ? 45  ARG A CZ   1 
ATOM   846  N  NH1  A ARG A 1 45  ? -18.06000 -15.85100 7.13500   0.680 33.90799 ? 45  ARG A NH1  1 
ATOM   847  N  NH1  B ARG A 1 45  ? -18.03000 -14.44300 3.95500   0.320 35.73281 ? 45  ARG A NH1  1 
ATOM   848  N  NH2  A ARG A 1 45  ? -19.48100 -14.94500 5.59200   0.680 43.08113 ? 45  ARG A NH2  1 
ATOM   849  N  NH2  B ARG A 1 45  ? -19.57800 -15.29300 2.50200   0.320 33.76584 ? 45  ARG A NH2  1 
ATOM   850  H  H    A ARG A 1 45  ? -15.22700 -19.05500 0.96300   0.680 23.16558 ? 45  ARG A H    1 
ATOM   851  H  H    B ARG A 1 45  ? -15.15400 -19.35100 0.97600   0.320 23.47157 ? 45  ARG A H    1 
ATOM   852  H  HA   A ARG A 1 45  ? -14.62600 -18.83300 3.55800   0.680 26.04423 ? 45  ARG A HA   1 
ATOM   853  H  HA   B ARG A 1 45  ? -14.48200 -18.87600 3.54400   0.320 26.25172 ? 45  ARG A HA   1 
ATOM   854  H  HB2  A ARG A 1 45  ? -16.53500 -17.75100 2.63700   0.680 30.51330 ? 45  ARG A HB2  1 
ATOM   855  H  HB2  B ARG A 1 45  ? -16.28700 -17.57700 2.76500   0.320 30.45891 ? 45  ARG A HB2  1 
ATOM   856  H  HB3  A ARG A 1 45  ? -17.18800 -19.18300 2.41700   0.680 30.51330 ? 45  ARG A HB3  1 
ATOM   857  H  HB3  B ARG A 1 45  ? -17.12100 -18.91200 2.54700   0.320 30.45891 ? 45  ARG A HB3  1 
ATOM   858  H  HG2  A ARG A 1 45  ? -18.11100 -18.68100 4.33800   0.680 34.56041 ? 45  ARG A HG2  1 
ATOM   859  H  HG2  B ARG A 1 45  ? -17.61200 -19.07000 4.66900   0.320 34.42934 ? 45  ARG A HG2  1 
ATOM   860  H  HG3  A ARG A 1 45  ? -16.78500 -19.36400 4.88600   0.680 34.56041 ? 45  ARG A HG3  1 
ATOM   861  H  HG3  B ARG A 1 45  ? -16.15300 -18.63100 5.12000   0.320 34.42934 ? 45  ARG A HG3  1 
ATOM   862  H  HD2  A ARG A 1 45  ? -16.63500 -17.50000 6.00800   0.680 35.42415 ? 45  ARG A HD2  1 
ATOM   863  H  HD2  B ARG A 1 45  ? -17.81400 -17.05700 5.71000   0.320 43.90318 ? 45  ARG A HD2  1 
ATOM   864  H  HD3  A ARG A 1 45  ? -15.95500 -16.98200 4.66800   0.680 35.42415 ? 45  ARG A HD3  1 
ATOM   865  H  HD3  B ARG A 1 45  ? -16.67100 -16.43000 4.80100   0.320 43.90318 ? 45  ARG A HD3  1 
ATOM   866  H  HE   A ARG A 1 45  ? -18.09900 -16.20300 4.08700   0.680 56.88721 ? 45  ARG A HE   1 
ATOM   867  H  HE   B ARG A 1 45  ? -18.83300 -17.35800 3.46500   0.320 48.53296 ? 45  ARG A HE   1 
ATOM   868  H  HH11 A ARG A 1 45  ? -17.39300 -16.35700 7.33100   0.680 40.69316 ? 45  ARG A HH11 1 
ATOM   869  H  HH11 B ARG A 1 45  ? -17.42900 -14.55900 4.55900   0.320 42.88294 ? 45  ARG A HH11 1 
ATOM   870  H  HH12 A ARG A 1 45  ? -18.47400 -15.42500 7.75700   0.680 40.69316 ? 45  ARG A HH12 1 
ATOM   871  H  HH12 B ARG A 1 45  ? -18.22200 -13.64900 3.68600   0.320 42.88294 ? 45  ARG A HH12 1 
ATOM   872  H  HH21 A ARG A 1 45  ? -19.74300 -14.85700 4.77800   0.680 51.70093 ? 45  ARG A HH21 1 
ATOM   873  H  HH21 B ARG A 1 45  ? -19.98700 -15.96600 2.15700   0.320 40.52257 ? 45  ARG A HH21 1 
ATOM   874  H  HH22 A ARG A 1 45  ? -19.88700 -14.52300 6.22200   0.680 51.70093 ? 45  ARG A HH22 1 
ATOM   875  H  HH22 B ARG A 1 45  ? -19.76400 -14.49600 2.23800   0.320 40.52257 ? 45  ARG A HH22 1 
ATOM   876  N  N    . ASN A 1 46  ? -15.03600 -21.02800 4.58200   1.000 22.18195 ? 46  ASN A N    1 
ATOM   877  C  CA   . ASN A 1 46  ? -15.11500 -22.37500 5.14000   1.000 25.18031 ? 46  ASN A CA   1 
ATOM   878  C  C    . ASN A 1 46  ? -16.39100 -22.52600 5.95600   1.000 24.65922 ? 46  ASN A C    1 
ATOM   879  O  O    . ASN A 1 46  ? -17.01300 -21.55100 6.36900   1.000 28.02815 ? 46  ASN A O    1 
ATOM   880  C  CB   . ASN A 1 46  ? -13.92200 -22.64600 6.06100   1.000 25.85387 ? 46  ASN A CB   1 
ATOM   881  C  CG   . ASN A 1 46  ? -12.57500 -22.43800 5.37100   1.000 26.72462 ? 46  ASN A CG   1 
ATOM   882  O  OD1  . ASN A 1 46  ? -11.69300 -21.73900 5.88400   1.000 33.91533 ? 46  ASN A OD1  1 
ATOM   883  N  ND2  . ASN A 1 46  ? -12.41700 -23.05300 4.22600   1.000 33.00390 ? 46  ASN A ND2  1 
ATOM   884  H  H    . ASN A 1 46  ? -14.82100 -20.43300 5.16500   1.000 26.62191 ? 46  ASN A H    1 
ATOM   885  H  HA   . ASN A 1 46  ? -15.11300 -23.01900 4.41500   1.000 30.21994 ? 46  ASN A HA   1 
ATOM   886  H  HB2  . ASN A 1 46  ? -13.96600 -22.04200 6.81900   1.000 31.02821 ? 46  ASN A HB2  1 
ATOM   887  H  HB3  . ASN A 1 46  ? -13.96200 -23.56500 6.36700   1.000 31.02821 ? 46  ASN A HB3  1 
ATOM   888  H  HD21 . ASN A 1 46  ? -11.67800 -22.97200 3.79300   1.000 39.60825 ? 46  ASN A HD21 1 
ATOM   889  H  HD22 . ASN A 1 46  ? -13.05100 -23.53900 3.90700   1.000 39.60825 ? 46  ASN A HD22 1 
ATOM   890  N  N    . THR A 1 47  ? -16.73300 -23.78800 6.23700   1.000 32.88591 ? 47  THR A N    1 
ATOM   891  C  CA   . THR A 1 47  ? -17.97800 -24.08900 6.94200   1.000 35.96882 ? 47  THR A CA   1 
ATOM   892  C  C    . THR A 1 47  ? -17.98800 -23.48300 8.33700   1.000 31.84889 ? 47  THR A C    1 
ATOM   893  O  O    . THR A 1 47  ? -19.03600 -23.03000 8.82100   1.000 36.40059 ? 47  THR A O    1 
ATOM   894  C  CB   . THR A 1 47  ? -18.15800 -25.60800 7.04100   1.000 40.00804 ? 47  THR A CB   1 
ATOM   895  O  OG1  . THR A 1 47  ? -16.90600 -26.22300 7.36800   1.000 52.43714 ? 47  THR A OG1  1 
ATOM   896  C  CG2  . THR A 1 47  ? -18.63800 -26.15200 5.71700   1.000 50.54938 ? 47  THR A CG2  1 
ATOM   897  H  H    . THR A 1 47  ? -16.26500 -24.48100 6.03200   1.000 39.46666 ? 47  THR A H    1 
ATOM   898  H  HA   . THR A 1 47  ? -18.71700 -23.71100 6.44000   1.000 43.16615 ? 47  THR A HA   1 
ATOM   899  H  HB   . THR A 1 47  ? -18.81000 -25.81600 7.72900   1.000 48.01321 ? 47  THR A HB   1 
ATOM   900  H  HG1  . THR A 1 47  ? -16.99100 -27.05900 7.38000   1.000 62.92814 ? 47  THR A HG1  1 
ATOM   901  H  HG21 . THR A 1 47  ? -18.75800 -27.11300 5.77700   1.000 60.66282 ? 47  THR A HG21 1 
ATOM   902  H  HG22 . THR A 1 47  ? -19.48500 -25.74300 5.47800   1.000 60.66282 ? 47  THR A HG22 1 
ATOM   903  H  HG23 . THR A 1 47  ? -17.98800 -25.95800 5.02400   1.000 60.66282 ? 47  THR A HG23 1 
ATOM   904  N  N    A ASP A 1 48  ? -16.83300 -23.46400 8.99800   0.820 28.78348 ? 48  ASP A N    1 
ATOM   905  N  N    B ASP A 1 48  ? -16.83500 -23.46500 9.00400   0.180 28.97140 ? 48  ASP A N    1 
ATOM   906  C  CA   A ASP A 1 48  ? -16.76500 -22.94700 10.36100  0.820 31.08979 ? 48  ASP A CA   1 
ATOM   907  C  CA   B ASP A 1 48  ? -16.76500 -22.94000 10.36200  0.180 31.18098 ? 48  ASP A CA   1 
ATOM   908  C  C    A ASP A 1 48  ? -16.84800 -21.42800 10.42700  0.820 31.15837 ? 48  ASP A C    1 
ATOM   909  C  C    B ASP A 1 48  ? -16.83600 -21.41900 10.42200  0.180 31.26122 ? 48  ASP A C    1 
ATOM   910  O  O    A ASP A 1 48  ? -16.76800 -20.87600 11.53200  0.820 37.77435 ? 48  ASP A O    1 
ATOM   911  O  O    B ASP A 1 48  ? -16.73700 -20.86300 11.52100  0.180 37.43876 ? 48  ASP A O    1 
ATOM   912  C  CB   A ASP A 1 48  ? -15.51400 -23.47500 11.07400  0.820 30.37743 ? 48  ASP A CB   1 
ATOM   913  C  CB   B ASP A 1 48  ? -15.48600 -23.42900 11.04700  0.180 30.56771 ? 48  ASP A CB   1 
ATOM   914  C  CG   A ASP A 1 48  ? -14.21500 -22.94700 10.49200  0.820 30.53082 ? 48  ASP A CG   1 
ATOM   915  C  CG   B ASP A 1 48  ? -14.23200 -23.04100 10.29100  0.180 31.36134 ? 48  ASP A CG   1 
ATOM   916  O  OD1  A ASP A 1 48  ? -14.25200 -22.16800 9.51000   0.820 27.04181 ? 48  ASP A OD1  1 
ATOM   917  O  OD1  B ASP A 1 48  ? -13.71200 -21.92700 10.52200  0.180 29.35929 ? 48  ASP A OD1  1 
ATOM   918  O  OD2  A ASP A 1 48  ? -13.14900 -23.31400 11.02300  0.820 32.72782 ? 48  ASP A OD2  1 
ATOM   919  O  OD2  B ASP A 1 48  ? -13.76500 -23.85400 9.46500   0.180 31.13116 ? 48  ASP A OD2  1 
ATOM   920  H  H    A ASP A 1 48  ? -16.08300 -23.74200 8.68300   0.820 34.54374 ? 48  ASP A H    1 
ATOM   921  H  H    B ASP A 1 48  ? -16.08600 -23.74900 8.69200   0.180 34.76924 ? 48  ASP A H    1 
ATOM   922  H  HA   A ASP A 1 48  ? -17.52300 -23.28600 10.86200  0.820 37.31132 ? 48  ASP A HA   1 
ATOM   923  H  HA   B ASP A 1 48  ? -17.52000 -23.28600 10.86300  0.180 37.42074 ? 48  ASP A HA   1 
ATOM   924  H  HB2  A ASP A 1 48  ? -15.55000 -23.21100 12.00700  0.820 36.45648 ? 48  ASP A HB2  1 
ATOM   925  H  HB2  B ASP A 1 48  ? -15.43400 -23.04000 11.93400  0.180 36.68482 ? 48  ASP A HB2  1 
ATOM   926  H  HB3  A ASP A 1 48  ? -15.49800 -24.44300 11.00300  0.820 36.45648 ? 48  ASP A HB3  1 
ATOM   927  H  HB3  B ASP A 1 48  ? -15.51200 -24.39600 11.11000  0.180 36.68482 ? 48  ASP A HB3  1 
ATOM   928  N  N    . GLY A 1 49  ? -17.00200 -20.73400 9.29000   1.000 29.17955 ? 49  GLY A N    1 
ATOM   929  C  CA   . GLY A 1 49  ? -17.08400 -19.29100 9.26400   1.000 26.61316 ? 49  GLY A CA   1 
ATOM   930  C  C    . GLY A 1 49  ? -15.76500 -18.58600 9.01700   1.000 26.42334 ? 49  GLY A C    1 
ATOM   931  O  O    . GLY A 1 49  ? -15.74700 -17.36300 8.82100   1.000 27.58879 ? 49  GLY A O    1 
ATOM   932  H  H    . GLY A 1 49  ? -17.06100 -21.09400 8.51200   1.000 35.01903 ? 49  GLY A H    1 
ATOM   933  H  HA2  . GLY A 1 49  ? -17.69800 -19.02800 8.56000   1.000 31.93936 ? 49  GLY A HA2  1 
ATOM   934  H  HA3  . GLY A 1 49  ? -17.43000 -18.98300 10.11600  1.000 31.93936 ? 49  GLY A HA3  1 
ATOM   935  N  N    . SER A 1 50  ? -14.66700 -19.30900 9.02700   1.000 22.66801 ? 50  SER A N    1 
ATOM   936  C  CA   . SER A 1 50  ? -13.39200 -18.71700 8.68400   1.000 21.34806 ? 50  SER A CA   1 
ATOM   937  C  C    . SER A 1 50  ? -13.29400 -18.60600 7.16900   1.000 19.04979 ? 50  SER A C    1 
ATOM   938  O  O    . SER A 1 50  ? -14.11700 -19.12300 6.43000   1.000 21.44706 ? 50  SER A O    1 
ATOM   939  C  CB   . SER A 1 50  ? -12.24100 -19.53900 9.24400   1.000 21.09648 ? 50  SER A CB   1 
ATOM   940  O  OG   . SER A 1 50  ? -12.18700 -20.81300 8.64300   1.000 21.95093 ? 50  SER A OG   1 
ATOM   941  H  H    . SER A 1 50  ? -14.63100 -20.14400 9.22800   1.000 27.20519 ? 50  SER A H    1 
ATOM   942  H  HA   . SER A 1 50  ? -13.32000 -17.83200 9.07400   1.000 25.62124 ? 50  SER A HA   1 
ATOM   943  H  HB2  . SER A 1 50  ? -11.40800 -19.07400 9.07000   1.000 25.31935 ? 50  SER A HB2  1 
ATOM   944  H  HB3  . SER A 1 50  ? -12.36700 -19.64700 10.19900  1.000 25.31935 ? 50  SER A HB3  1 
ATOM   945  H  HG   . SER A 1 50  ? -12.96200 -21.07200 8.44900   1.000 26.34468 ? 50  SER A HG   1 
ATOM   946  N  N    . THR A 1 51  ? -12.27900 -17.88300 6.71000   1.000 17.27959 ? 51  THR A N    1 
ATOM   947  C  CA   . THR A 1 51  ? -12.03500 -17.64800 5.28900   1.000 14.98006 ? 51  THR A CA   1 
ATOM   948  C  C    . THR A 1 51  ? -10.55200 -17.88500 5.01200   1.000 15.85731 ? 51  THR A C    1 
ATOM   949  O  O    . THR A 1 51  ? -9.69400  -17.58700 5.85200   1.000 16.85492 ? 51  THR A O    1 
ATOM   950  C  CB   . THR A 1 51  ? -12.43500 -16.20700 4.92500   1.000 16.41044 ? 51  THR A CB   1 
ATOM   951  O  OG1  . THR A 1 51  ? -13.82500 -16.02400 5.22700   1.000 18.22631 ? 51  THR A OG1  1 
ATOM   952  C  CG2  . THR A 1 51  ? -12.25600 -15.91800 3.46500   1.000 19.81300 ? 51  THR A CG2  1 
ATOM   953  H  H    . THR A 1 51  ? -11.69700 -17.50400 7.21800   1.000 20.73908 ? 51  THR A H    1 
ATOM   954  H  HA   . THR A 1 51  ? -12.54300 -18.25600 4.72900   1.000 17.97964 ? 51  THR A HA   1 
ATOM   955  H  HB   . THR A 1 51  ? -11.86900 -15.60100 5.42800   1.000 19.69610 ? 51  THR A HB   1 
ATOM   956  H  HG1  . THR A 1 51  ? -13.97300 -16.22400 6.02900   1.000 21.87515 ? 51  THR A HG1  1 
ATOM   957  H  HG21 . THR A 1 51  ? -12.49000 -14.99600 3.27800   1.000 23.77917 ? 51  THR A HG21 1 
ATOM   958  H  HG22 . THR A 1 51  ? -11.33200 -16.06600 3.20800   1.000 23.77917 ? 51  THR A HG22 1 
ATOM   959  H  HG23 . THR A 1 51  ? -12.82600 -16.50000 2.93900   1.000 23.77917 ? 51  THR A HG23 1 
ATOM   960  N  N    A ASP A 1 52  ? -10.24900 -18.40900 3.82000   0.440 15.93192 ? 52  ASP A N    1 
ATOM   961  N  N    B ASP A 1 52  ? -10.26600 -18.41200 3.82100   0.560 15.97678 ? 52  ASP A N    1 
ATOM   962  C  CA   A ASP A 1 52  ? -8.88200  -18.61600 3.35700   0.440 16.64945 ? 52  ASP A CA   1 
ATOM   963  C  CA   B ASP A 1 52  ? -8.91700  -18.60900 3.31100   0.560 16.50763 ? 52  ASP A CA   1 
ATOM   964  C  C    A ASP A 1 52  ? -8.52000  -17.58500 2.28800   0.440 15.08750 ? 52  ASP A C    1 
ATOM   965  C  C    B ASP A 1 52  ? -8.56200  -17.47500 2.35000   0.560 14.70406 ? 52  ASP A C    1 
ATOM   966  O  O    A ASP A 1 52  ? -9.29400  -17.37200 1.34100   0.440 15.59560 ? 52  ASP A O    1 
ATOM   967  O  O    B ASP A 1 52  ? -9.40800  -17.04000 1.55900   0.560 16.58558 ? 52  ASP A O    1 
ATOM   968  C  CB   A ASP A 1 52  ? -8.70500  -20.02700 2.77300   0.440 17.22691 ? 52  ASP A CB   1 
ATOM   969  C  CB   B ASP A 1 52  ? -8.85100  -19.95700 2.58100   0.560 17.45255 ? 52  ASP A CB   1 
ATOM   970  C  CG   A ASP A 1 52  ? -9.46300  -21.08800 3.54400   0.440 18.17946 ? 52  ASP A CG   1 
ATOM   971  C  CG   B ASP A 1 52  ? -8.83100  -21.13300 3.53100   0.560 18.77597 ? 52  ASP A CG   1 
ATOM   972  O  OD1  A ASP A 1 52  ? -9.26600  -21.19200 4.76500   0.440 19.56418 ? 52  ASP A OD1  1 
ATOM   973  O  OD1  B ASP A 1 52  ? -8.62300  -20.92500 4.73900   0.560 17.31385 ? 52  ASP A OD1  1 
ATOM   974  O  OD2  A ASP A 1 52  ? -10.24300 -21.84500 2.92000   0.440 27.44348 ? 52  ASP A OD2  1 
ATOM   975  O  OD2  B ASP A 1 52  ? -9.00600  -22.26700 3.05600   0.560 21.67648 ? 52  ASP A OD2  1 
ATOM   976  H  H    A ASP A 1 52  ? -10.84000 -18.65900 3.24700   0.440 19.12187 ? 52  ASP A H    1 
ATOM   977  H  H    B ASP A 1 52  ? -10.86800 -18.67400 3.26600   0.560 19.17571 ? 52  ASP A H    1 
ATOM   978  H  HA   A ASP A 1 52  ? -8.27700  -18.50600 4.10700   0.440 19.98291 ? 52  ASP A HA   1 
ATOM   979  H  HA   B ASP A 1 52  ? -8.26900  -18.60300 4.03200   0.560 19.81273 ? 52  ASP A HA   1 
ATOM   980  H  HB2  A ASP A 1 52  ? -9.02900  -20.03200 1.85900   0.440 20.67586 ? 52  ASP A HB2  1 
ATOM   981  H  HB2  B ASP A 1 52  ? -9.63000  -20.04500 2.01000   0.560 20.94662 ? 52  ASP A HB2  1 
ATOM   982  H  HB3  A ASP A 1 52  ? -7.76300  -20.26000 2.79200   0.440 20.67586 ? 52  ASP A HB3  1 
ATOM   983  H  HB3  B ASP A 1 52  ? -8.04300  -19.98800 2.04700   0.560 20.94662 ? 52  ASP A HB3  1 
ATOM   984  N  N    . TYR A 1 53  ? -7.31400  -17.00900 2.39800   1.000 14.92362 ? 53  TYR A N    1 
ATOM   985  C  CA   . TYR A 1 53  ? -6.90700  -15.83000 1.64100   1.000 15.43926 ? 53  TYR A CA   1 
ATOM   986  C  C    . TYR A 1 53  ? -5.60000  -16.01500 0.88400   1.000 15.78646 ? 53  TYR A C    1 
ATOM   987  O  O    . TYR A 1 53  ? -4.58400  -16.44800 1.44700   1.000 16.61640 ? 53  TYR A O    1 
ATOM   988  C  CB   . TYR A 1 53  ? -6.68800  -14.64500 2.60000   1.000 16.22531 ? 53  TYR A CB   1 
ATOM   989  C  CG   . TYR A 1 53  ? -7.93700  -14.17800 3.32100   1.000 16.71104 ? 53  TYR A CG   1 
ATOM   990  C  CD1  . TYR A 1 53  ? -8.35600  -14.76000 4.50100   1.000 17.24730 ? 53  TYR A CD1  1 
ATOM   991  C  CD2  . TYR A 1 53  ? -8.71300  -13.15100 2.78800   1.000 19.03837 ? 53  TYR A CD2  1 
ATOM   992  C  CE1  . TYR A 1 53  ? -9.51000  -14.34600 5.13500   1.000 16.65848 ? 53  TYR A CE1  1 
ATOM   993  C  CE2  . TYR A 1 53  ? -9.87200  -12.73500 3.42100   1.000 17.49491 ? 53  TYR A CE2  1 
ATOM   994  C  CZ   . TYR A 1 53  ? -10.24200 -13.31700 4.57700   1.000 17.24323 ? 53  TYR A CZ   1 
ATOM   995  O  OH   . TYR A 1 53  ? -11.40200 -12.89500 5.19400   1.000 18.68245 ? 53  TYR A OH   1 
ATOM   996  H  H    . TYR A 1 53  ? -6.68300  -17.36000 2.86400   1.000 17.91191 ? 53  TYR A H    1 
ATOM   997  H  HA   . TYR A 1 53  ? -7.60500  -15.67200 0.98600   1.000 18.53068 ? 53  TYR A HA   1 
ATOM   998  H  HB2  . TYR A 1 53  ? -6.04300  -14.90900 3.27500   1.000 19.47394 ? 53  TYR A HB2  1 
ATOM   999  H  HB3  . TYR A 1 53  ? -6.34600  -13.89400 2.09000   1.000 19.47394 ? 53  TYR A HB3  1 
ATOM   1000 H  HD1  . TYR A 1 53  ? -7.85100  -15.44500 4.87700   1.000 20.70033 ? 53  TYR A HD1  1 
ATOM   1001 H  HD2  . TYR A 1 53  ? -8.44900  -12.74000 1.99700   1.000 22.84962 ? 53  TYR A HD2  1 
ATOM   1002 H  HE1  . TYR A 1 53  ? -9.79000  -14.75300 5.92300   1.000 19.99375 ? 53  TYR A HE1  1 
ATOM   1003 H  HE2  . TYR A 1 53  ? -10.39000 -12.05700 3.05100   1.000 20.99746 ? 53  TYR A HE2  1 
ATOM   1004 H  HH   . TYR A 1 53  ? -11.72600 -13.51800 5.65600   1.000 22.42251 ? 53  TYR A HH   1 
ATOM   1005 N  N    . GLY A 1 54  ? -5.63700  -15.63400 -0.38900  1.000 15.86750 ? 54  GLY A N    1 
ATOM   1006 C  CA   . GLY A 1 54  ? -4.44300  -15.40100 -1.17100  1.000 17.56903 ? 54  GLY A CA   1 
ATOM   1007 C  C    . GLY A 1 54  ? -3.93600  -16.64200 -1.86900  1.000 15.87066 ? 54  GLY A C    1 
ATOM   1008 O  O    . GLY A 1 54  ? -4.56400  -17.69300 -1.94500  1.000 16.45786 ? 54  GLY A O    1 
ATOM   1009 H  H    . GLY A 1 54  ? -6.36400  -15.50100 -0.82900  1.000 19.04457 ? 54  GLY A H    1 
ATOM   1010 H  HA2  . GLY A 1 54  ? -4.63200  -14.73000 -1.84600  1.000 21.08640 ? 54  GLY A HA2  1 
ATOM   1011 H  HA3  . GLY A 1 54  ? -3.74000  -15.07300 -0.58800  1.000 21.08640 ? 54  GLY A HA3  1 
ATOM   1012 N  N    . ILE A 1 55  ? -2.71500  -16.47600 -2.39300  1.000 17.00104 ? 55  ILE A N    1 
ATOM   1013 C  CA   . ILE A 1 55  ? -2.08800  -17.46900 -3.25100  1.000 18.00249 ? 55  ILE A CA   1 
ATOM   1014 C  C    . ILE A 1 55  ? -1.92000  -18.81200 -2.55000  1.000 16.78579 ? 55  ILE A C    1 
ATOM   1015 O  O    . ILE A 1 55  ? -1.97100  -19.86700 -3.19300  1.000 18.59099 ? 55  ILE A O    1 
ATOM   1016 C  CB   . ILE A 1 55  ? -0.76700  -16.83300 -3.74000  1.000 23.87508 ? 55  ILE A CB   1 
ATOM   1017 C  CG1  . ILE A 1 55  ? -0.20400  -17.52400 -4.96800  1.000 37.17932 ? 55  ILE A CG1  1 
ATOM   1018 C  CG2  . ILE A 1 55  ? 0.25400   -16.76100 -2.63800  1.000 25.34193 ? 55  ILE A CG2  1 
ATOM   1019 C  CD1  . ILE A 1 55  ? -0.63000  -16.85700 -6.20900  1.000 45.31239 ? 55  ILE A CD1  1 
ATOM   1020 H  H    . ILE A 1 55  ? -2.22500  -15.78200 -2.26100  1.000 20.40482 ? 55  ILE A H    1 
ATOM   1021 H  HA   . ILE A 1 55  ? -2.64600  -17.68500 -4.01500  1.000 21.60655 ? 55  ILE A HA   1 
ATOM   1022 H  HB   . ILE A 1 55  ? -0.98500  -15.92600 -4.00700  1.000 28.65366 ? 55  ILE A HB   1 
ATOM   1023 H  HG12 . ILE A 1 55  ? 0.76500   -17.50600 -4.92900  1.000 44.61875 ? 55  ILE A HG12 1 
ATOM   1024 H  HG13 . ILE A 1 55  ? -0.51900  -18.44100 -4.99100  1.000 44.61875 ? 55  ILE A HG13 1 
ATOM   1025 H  HG21 . ILE A 1 55  ? 1.05800   -16.33900 -2.97800  1.000 30.41389 ? 55  ILE A HG21 1 
ATOM   1026 H  HG22 . ILE A 1 55  ? -0.10900  -16.23900 -1.90500  1.000 30.41389 ? 55  ILE A HG22 1 
ATOM   1027 H  HG23 . ILE A 1 55  ? 0.45500   -17.66000 -2.33500  1.000 30.41389 ? 55  ILE A HG23 1 
ATOM   1028 H  HD11 . ILE A 1 55  ? -0.25400  -17.33100 -6.96700  1.000 54.37844 ? 55  ILE A HD11 1 
ATOM   1029 H  HD12 . ILE A 1 55  ? -1.59900  -16.87000 -6.25800  1.000 54.37844 ? 55  ILE A HD12 1 
ATOM   1030 H  HD13 . ILE A 1 55  ? -0.31200  -15.94100 -6.20000  1.000 54.37844 ? 55  ILE A HD13 1 
ATOM   1031 N  N    . LEU A 1 56  ? -1.73200  -18.81600 -1.22900  1.000 17.61246 ? 56  LEU A N    1 
ATOM   1032 C  CA   . LEU A 1 56  ? -1.59300  -20.04000 -0.44200  1.000 17.86121 ? 56  LEU A CA   1 
ATOM   1033 C  C    . LEU A 1 56  ? -2.76900  -20.28100 0.50700   1.000 19.62078 ? 56  LEU A C    1 
ATOM   1034 O  O    . LEU A 1 56  ? -2.70700  -21.14500 1.39100   1.000 19.50867 ? 56  LEU A O    1 
ATOM   1035 C  CB   . LEU A 1 56  ? -0.25900  -20.07600 0.30000   1.000 19.86890 ? 56  LEU A CB   1 
ATOM   1036 C  CG   . LEU A 1 56  ? 0.94800   -20.35900 -0.60700  1.000 22.30947 ? 56  LEU A CG   1 
ATOM   1037 C  CD1  . LEU A 1 56  ? 2.24900   -19.98900 0.10700   1.000 25.85388 ? 56  LEU A CD1  1 
ATOM   1038 C  CD2  . LEU A 1 56  ? 0.93700   -21.81000 -1.05000  1.000 26.77519 ? 56  LEU A CD2  1 
ATOM   1039 H  H    . LEU A 1 56  ? -1.68000  -18.10100 -0.75400  1.000 21.13852 ? 56  LEU A H    1 
ATOM   1040 H  HA   . LEU A 1 56  ? -1.57800  -20.78700 -1.06000  1.000 21.43702 ? 56  LEU A HA   1 
ATOM   1041 H  HB2  . LEU A 1 56  ? -0.11600  -19.21500 0.72400   1.000 23.84625 ? 56  LEU A HB2  1 
ATOM   1042 H  HB3  . LEU A 1 56  ? -0.29600  -20.77500 0.97100   1.000 23.84625 ? 56  LEU A HB3  1 
ATOM   1043 H  HG   . LEU A 1 56  ? 0.89700   -19.81000 -1.40500  1.000 26.77494 ? 56  LEU A HG   1 
ATOM   1044 H  HD11 . LEU A 1 56  ? 2.99400   -20.14800 -0.49300  1.000 31.02822 ? 56  LEU A HD11 1 
ATOM   1045 H  HD12 . LEU A 1 56  ? 2.21800   -19.05200 0.35500   1.000 31.02822 ? 56  LEU A HD12 1 
ATOM   1046 H  HD13 . LEU A 1 56  ? 2.34100   -20.53900 0.90100   1.000 31.02822 ? 56  LEU A HD13 1 
ATOM   1047 H  HD21 . LEU A 1 56  ? 1.80700   -22.03500 -1.41700  1.000 32.13380 ? 56  LEU A HD21 1 
ATOM   1048 H  HD22 . LEU A 1 56  ? 0.74600   -22.37300 -0.28400  1.000 32.13380 ? 56  LEU A HD22 1 
ATOM   1049 H  HD23 . LEU A 1 56  ? 0.25300   -21.92800 -1.72700  1.000 32.13380 ? 56  LEU A HD23 1 
ATOM   1050 N  N    . GLN A 1 57  ? -3.87300  -19.56400 0.32900   1.000 16.21252 ? 57  GLN A N    1 
ATOM   1051 C  CA   . GLN A 1 57  ? -5.12100  -19.85600 1.02100   1.000 16.25943 ? 57  GLN A CA   1 
ATOM   1052 C  C    . GLN A 1 57  ? -4.93800  -19.99100 2.53900   1.000 17.91604 ? 57  GLN A C    1 
ATOM   1053 O  O    . GLN A 1 57  ? -5.35500  -20.97100 3.16100   1.000 19.31795 ? 57  GLN A O    1 
ATOM   1054 C  CB   . GLN A 1 57  ? -5.81700  -21.05600 0.38600   1.000 16.36414 ? 57  GLN A CB   1 
ATOM   1055 C  CG   . GLN A 1 57  ? -6.35400  -20.75500 -1.00500  1.000 16.98318 ? 57  GLN A CG   1 
ATOM   1056 C  CD   . GLN A 1 57  ? -7.54200  -19.83200 -0.96000  1.000 17.07404 ? 57  GLN A CD   1 
ATOM   1057 O  OE1  . GLN A 1 57  ? -8.64600  -20.26100 -0.69100  1.000 18.97380 ? 57  GLN A OE1  1 
ATOM   1058 N  NE2  . GLN A 1 57  ? -7.31000  -18.54300 -1.18200  1.000 18.47929 ? 57  GLN A NE2  1 
ATOM   1059 H  H    . GLN A 1 57  ? -3.92500  -18.88900 -0.20100  1.000 19.45860 ? 57  GLN A H    1 
ATOM   1060 H  HA   . GLN A 1 57  ? -5.70900  -19.09200 0.91600   1.000 19.51489 ? 57  GLN A HA   1 
ATOM   1061 H  HB2  . GLN A 1 57  ? -5.18200  -21.78600 0.31200   1.000 19.64054 ? 57  GLN A HB2  1 
ATOM   1062 H  HB3  . GLN A 1 57  ? -6.56300  -21.32100 0.94600   1.000 19.64054 ? 57  GLN A HB3  1 
ATOM   1063 H  HG2  . GLN A 1 57  ? -5.65900  -20.32900 -1.53000  1.000 20.38338 ? 57  GLN A HG2  1 
ATOM   1064 H  HG3  . GLN A 1 57  ? -6.62900  -21.58300 -1.42700  1.000 20.38338 ? 57  GLN A HG3  1 
ATOM   1065 H  HE21 . GLN A 1 57  ? -6.50900  -18.27200 -1.34200  1.000 22.17871 ? 57  GLN A HE21 1 
ATOM   1066 H  HE22 . GLN A 1 57  ? -7.96000  -17.98000 -1.16700  1.000 22.17871 ? 57  GLN A HE22 1 
ATOM   1067 N  N    . ILE A 1 58  ? -4.40200  -18.94500 3.12600   1.000 17.45398 ? 58  ILE A N    1 
ATOM   1068 C  CA   . ILE A 1 58  ? -4.09100  -18.91500 4.55500   1.000 17.87602 ? 58  ILE A CA   1 
ATOM   1069 C  C    . ILE A 1 58  ? -5.36000  -18.58500 5.33300   0.780 15.81579 ? 58  ILE A C    1 
ATOM   1070 O  O    . ILE A 1 58  ? -6.08500  -17.64000 4.98700   1.000 17.71449 ? 58  ILE A O    1 
ATOM   1071 C  CB   . ILE A 1 58  ? -2.94200  -17.94800 4.80900   0.930 19.26621 ? 58  ILE A CB   1 
ATOM   1072 C  CG1  . ILE A 1 58  ? -1.67000  -18.59600 4.22500   1.000 22.10849 ? 58  ILE A CG1  1 
ATOM   1073 C  CG2  . ILE A 1 58  ? -2.80500  -17.62300 6.29700   0.760 17.34506 ? 58  ILE A CG2  1 
ATOM   1074 C  CD1  . ILE A 1 58  ? -0.50500  -17.69500 4.16500   0.830 23.68406 ? 58  ILE A CD1  1 
ATOM   1075 H  H    . ILE A 1 58  ? -4.20000  -18.21700 2.71700   1.000 20.94835 ? 58  ILE A H    1 
ATOM   1076 H  HA   . ILE A 1 58  ? -3.80500  -19.78800 4.86600   0.720 21.45479 ? 58  ILE A HA   1 
ATOM   1077 H  HB   . ILE A 1 58  ? -3.10500  -17.09600 4.37500   1.000 23.12302 ? 58  ILE A HB   1 
ATOM   1078 H  HG12 . ILE A 1 58  ? -1.42700  -19.35500 4.77900   1.000 26.53376 ? 58  ILE A HG12 1 
ATOM   1079 H  HG13 . ILE A 1 58  ? -1.86000  -18.89200 3.32100   1.000 26.53376 ? 58  ILE A HG13 1 
ATOM   1080 H  HG21 . ILE A 1 58  ? -2.01700  -17.07400 6.42900   1.000 20.81764 ? 58  ILE A HG21 1 
ATOM   1081 H  HG22 . ILE A 1 58  ? -3.59600  -17.14300 6.58900   0.750 20.81764 ? 58  ILE A HG22 1 
ATOM   1082 H  HG23 . ILE A 1 58  ? -2.71800  -18.45100 6.79400   0.720 20.81764 ? 58  ILE A HG23 1 
ATOM   1083 H  HD11 . ILE A 1 58  ? 0.22500   -18.15200 3.72000   0.500 28.42445 ? 58  ILE A HD11 1 
ATOM   1084 H  HD12 . ILE A 1 58  ? -0.74800  -16.89700 3.66900   0.390 28.42445 ? 58  ILE A HD12 1 
ATOM   1085 H  HD13 . ILE A 1 58  ? -0.24400  -17.45600 5.06800   0.230 28.42445 ? 58  ILE A HD13 1 
ATOM   1086 N  N    A ASN A 1 59  ? -5.66400  -19.37400 6.35800   0.190 18.01272 ? 59  ASN A N    1 
ATOM   1087 N  N    B ASN A 1 59  ? -5.59900  -19.34000 6.41400   0.260 18.03024 ? 59  ASN A N    1 
ATOM   1088 N  N    C ASN A 1 59  ? -5.63200  -19.38100 6.37600   0.550 17.92070 ? 59  ASN A N    1 
ATOM   1089 C  CA   A ASN A 1 59  ? -6.97200  -19.28300 6.99500   0.190 17.96582 ? 59  ASN A CA   1 
ATOM   1090 C  CA   B ASN A 1 59  ? -6.87700  -19.37400 7.12200   0.260 17.58384 ? 59  ASN A CA   1 
ATOM   1091 C  CA   C ASN A 1 59  ? -6.91800  -19.40400 7.07100   0.550 17.48160 ? 59  ASN A CA   1 
ATOM   1092 C  C    A ASN A 1 59  ? -6.96600  -18.28600 8.15100   0.190 18.45442 ? 59  ASN A C    1 
ATOM   1093 C  C    B ASN A 1 59  ? -6.98300  -18.25900 8.15900   0.260 18.43389 ? 59  ASN A C    1 
ATOM   1094 C  C    C ASN A 1 59  ? -7.00400  -18.41600 8.22200   0.550 18.26154 ? 59  ASN A C    1 
ATOM   1095 O  O    A ASN A 1 59  ? -5.96900  -18.12200 8.86300   0.190 19.41072 ? 59  ASN A O    1 
ATOM   1096 O  O    B ASN A 1 59  ? -5.99800  -17.88400 8.80800   0.260 17.55050 ? 59  ASN A O    1 
ATOM   1097 O  O    C ASN A 1 59  ? -6.17400  -18.43800 9.12700   0.550 20.85737 ? 59  ASN A O    1 
ATOM   1098 C  CB   A ASN A 1 59  ? -7.43700  -20.66400 7.46400   0.190 21.11849 ? 59  ASN A CB   1 
ATOM   1099 C  CB   B ASN A 1 59  ? -7.03600  -20.74600 7.79700   0.260 20.75740 ? 59  ASN A CB   1 
ATOM   1100 C  CB   C ASN A 1 59  ? -7.17000  -20.81200 7.60800   0.550 20.99827 ? 59  ASN A CB   1 
ATOM   1101 C  CG   A ASN A 1 59  ? -6.81900  -21.06700 8.77700   0.190 21.06252 ? 59  ASN A CG   1 
ATOM   1102 C  CG   B ASN A 1 59  ? -8.48900  -21.09700 8.10800   0.260 20.38848 ? 59  ASN A CG   1 
ATOM   1103 C  CG   C ASN A 1 59  ? -8.51100  -20.93800 8.27100   0.550 21.89180 ? 59  ASN A CG   1 
ATOM   1104 O  OD1  A ASN A 1 59  ? -7.17000  -20.53000 9.82500   0.190 23.02014 ? 59  ASN A OD1  1 
ATOM   1105 O  OD1  B ASN A 1 59  ? -9.32300  -20.22500 8.32900   0.260 21.17434 ? 59  ASN A OD1  1 
ATOM   1106 O  OD1  C ASN A 1 59  ? -8.65400  -20.76600 9.49900   0.550 21.94451 ? 59  ASN A OD1  1 
ATOM   1107 N  ND2  A ASN A 1 59  ? -5.89100  -22.01800 8.73100   0.190 23.76984 ? 59  ASN A ND2  1 
ATOM   1108 N  ND2  B ASN A 1 59  ? -8.78800  -22.39100 8.14100   0.260 23.51934 ? 59  ASN A ND2  1 
ATOM   1109 N  ND2  C ASN A 1 59  ? -9.51800  -21.22200 7.46900   0.550 20.82254 ? 59  ASN A ND2  1 
ATOM   1110 H  H    A ASN A 1 59  ? -5.13700  -19.96200 6.69700   0.080 21.61883 ? 59  ASN A H    1 
ATOM   1111 H  H    B ASN A 1 59  ? -5.01200  -19.85900 6.76600   0.000 21.63985 ? 59  ASN A H    1 
ATOM   1112 H  H    C ASN A 1 59  ? -5.06500  -19.93600 6.70900   0.000 21.50841 ? 59  ASN A H    1 
ATOM   1113 H  HA   A ASN A 1 59  ? -7.61800  -18.95600 6.35000   0.190 21.56255 ? 59  ASN A HA   1 
ATOM   1114 H  HA   B ASN A 1 59  ? -7.60000  -19.23200 6.49200   0.260 21.10418 ? 59  ASN A HA   1 
ATOM   1115 H  HA   C ASN A 1 59  ? -7.60400  -19.14900 6.43400   0.550 20.98149 ? 59  ASN A HA   1 
ATOM   1116 H  HB2  A ASN A 1 59  ? -8.40000  -20.65200 7.57600   0.190 25.34575 ? 59  ASN A HB2  1 
ATOM   1117 H  HB2  B ASN A 1 59  ? -6.68400  -21.43000 7.20600   0.260 24.91245 ? 59  ASN A HB2  1 
ATOM   1118 H  HB2  C ASN A 1 59  ? -7.13600  -21.44300 6.87300   0.550 25.20150 ? 59  ASN A HB2  1 
ATOM   1119 H  HB3  A ASN A 1 59  ? -7.18800  -21.32500 6.79900   0.190 25.34575 ? 59  ASN A HB3  1 
ATOM   1120 H  HB3  B ASN A 1 59  ? -6.54500  -20.74400 8.63300   0.260 24.91245 ? 59  ASN A HB3  1 
ATOM   1121 H  HB3  C ASN A 1 59  ? -6.48800  -21.02800 8.26300   0.550 25.20150 ? 59  ASN A HB3  1 
ATOM   1122 H  HD21 A ASN A 1 59  ? -5.51000  -22.28200 9.45600   0.190 28.52738 ? 59  ASN A HD21 1 
ATOM   1123 H  HD21 B ASN A 1 59  ? -9.59200  -22.64300 8.31200   0.260 28.22678 ? 59  ASN A HD21 1 
ATOM   1124 H  HD21 C ASN A 1 59  ? -10.31200 -21.30700 7.78900   0.550 24.99062 ? 59  ASN A HD21 1 
ATOM   1125 H  HD22 A ASN A 1 59  ? -5.67200  -22.36900 7.97800   0.190 28.52738 ? 59  ASN A HD22 1 
ATOM   1126 H  HD22 B ASN A 1 59  ? -8.17600  -22.97800 7.99300   0.260 28.22678 ? 59  ASN A HD22 1 
ATOM   1127 H  HD22 C ASN A 1 59  ? -9.38200  -21.32300 6.62600   0.550 24.99062 ? 59  ASN A HD22 1 
ATOM   1128 N  N    A SER A 1 60  ? -8.10200  -17.60600 8.32000   0.500 16.37747 ? 60  SER A N    1 
ATOM   1129 N  N    B SER A 1 60  ? -8.19900  -17.72800 8.30900   0.500 17.59209 ? 60  SER A N    1 
ATOM   1130 C  CA   A SER A 1 60  ? -8.26900  -16.59900 9.35800   0.500 17.10867 ? 60  SER A CA   1 
ATOM   1131 C  CA   B SER A 1 60  ? -8.48500  -16.67100 9.26600   0.500 17.67185 ? 60  SER A CA   1 
ATOM   1132 C  C    A SER A 1 60  ? -8.51700  -17.17200 10.74700  0.500 18.83649 ? 60  SER A C    1 
ATOM   1133 C  C    B SER A 1 60  ? -8.79200  -17.17500 10.67000  0.500 17.05027 ? 60  SER A C    1 
ATOM   1134 O  O    A SER A 1 60  ? -8.39100  -16.40900 11.71500  0.500 21.13019 ? 60  SER A O    1 
ATOM   1135 O  O    B SER A 1 60  ? -8.92000  -16.34500 11.57900  0.500 20.41018 ? 60  SER A O    1 
ATOM   1136 C  CB   A SER A 1 60  ? -9.42300  -15.66000 8.98500   0.500 19.47064 ? 60  SER A CB   1 
ATOM   1137 C  CB   B SER A 1 60  ? -9.67500  -15.83400 8.78600   0.500 17.53467 ? 60  SER A CB   1 
ATOM   1138 O  OG   A SER A 1 60  ? -10.63700 -16.37200 8.83900   0.500 17.37522 ? 60  SER A OG   1 
ATOM   1139 O  OG   B SER A 1 60  ? -10.86800 -16.58900 8.82900   0.500 20.32506 ? 60  SER A OG   1 
ATOM   1140 H  H    A SER A 1 60  ? -8.80400  -17.71500 7.83500   0.500 19.65654 ? 60  SER A H    1 
ATOM   1141 H  H    B SER A 1 60  ? -8.88700  -17.97300 7.85400   0.500 21.11407 ? 60  SER A H    1 
ATOM   1142 H  HA   A SER A 1 60  ? -7.44900  -16.08200 9.40700   0.500 20.53398 ? 60  SER A HA   1 
ATOM   1143 H  HA   B SER A 1 60  ? -7.70100  -16.10300 9.32000   0.500 21.20979 ? 60  SER A HA   1 
ATOM   1144 H  HB2  A SER A 1 60  ? -9.52900  -14.99900 9.68600   0.500 23.36834 ? 60  SER A HB2  1 
ATOM   1145 H  HB2  B SER A 1 60  ? -9.77000  -15.06000 9.36200   0.500 21.04518 ? 60  SER A HB2  1 
ATOM   1146 H  HB3  A SER A 1 60  ? -9.21300  -15.22200 8.14500   0.500 23.36834 ? 60  SER A HB3  1 
ATOM   1147 H  HB3  B SER A 1 60  ? -9.51400  -15.55000 7.87200   0.500 21.04518 ? 60  SER A HB3  1 
ATOM   1148 H  HG   A SER A 1 60  ? -10.79200 -16.82000 9.53200   0.500 20.85383 ? 60  SER A HG   1 
ATOM   1149 H  HG   B SER A 1 60  ? -11.07100 -16.75900 9.62600   0.500 24.39364 ? 60  SER A HG   1 
ATOM   1150 N  N    A ARG A 1 61  ? -8.83800  -18.46800 10.87000  0.410 20.01070 ? 61  ARG A N    1 
ATOM   1151 N  N    B ARG A 1 61  ? -8.91600  -18.48600 10.87400  0.590 20.35687 ? 61  ARG A N    1 
ATOM   1152 C  CA   A ARG A 1 61  ? -9.09800  -19.04000 12.19400  0.410 22.89806 ? 61  ARG A CA   1 
ATOM   1153 C  CA   B ARG A 1 61  ? -9.07300  -18.98900 12.24400  0.590 22.62137 ? 61  ARG A CA   1 
ATOM   1154 C  C    A ARG A 1 61  ? -7.83800  -19.10200 13.03400  0.410 21.66568 ? 61  ARG A C    1 
ATOM   1155 C  C    B ARG A 1 61  ? -7.76500  -18.85000 13.01200  0.590 23.09450 ? 61  ARG A C    1 
ATOM   1156 O  O    A ARG A 1 61  ? -7.92900  -19.09700 14.26700  0.410 23.18153 ? 61  ARG A O    1 
ATOM   1157 O  O    B ARG A 1 61  ? -7.74800  -18.43700 14.18400  0.590 24.34425 ? 61  ARG A O    1 
ATOM   1158 C  CB   A ARG A 1 61  ? -9.69200  -20.44500 12.10200  0.410 29.72577 ? 61  ARG A CB   1 
ATOM   1159 C  CB   B ARG A 1 61  ? -9.54600  -20.44300 12.21400  0.590 29.02349 ? 61  ARG A CB   1 
ATOM   1160 C  CG   A ARG A 1 61  ? -9.93500  -21.12600 13.47700  0.410 38.61854 ? 61  ARG A CG   1 
ATOM   1161 C  CG   B ARG A 1 61  ? -9.84900  -21.03500 13.59900  0.590 38.59817 ? 61  ARG A CG   1 
ATOM   1162 C  CD   A ARG A 1 61  ? -10.69900 -20.23100 14.45900  0.410 37.03568 ? 61  ARG A CD   1 
ATOM   1163 C  CD   B ARG A 1 61  ? -10.99100 -22.05700 13.61600  0.590 37.99199 ? 61  ARG A CD   1 
ATOM   1164 N  NE   A ARG A 1 61  ? -10.91200 -20.85300 15.76700  0.410 46.78212 ? 61  ARG A NE   1 
ATOM   1165 N  NE   B ARG A 1 61  ? -12.22500 -21.59000 12.99300  0.590 42.28969 ? 61  ARG A NE   1 
ATOM   1166 C  CZ   A ARG A 1 61  ? -10.06900 -20.78400 16.79200  0.410 45.54780 ? 61  ARG A CZ   1 
ATOM   1167 C  CZ   B ARG A 1 61  ? -13.04700 -20.69500 13.52500  0.590 47.59616 ? 61  ARG A CZ   1 
ATOM   1168 N  NH1  A ARG A 1 61  ? -8.91000  -20.15100 16.70000  0.410 40.97270 ? 61  ARG A NH1  1 
ATOM   1169 N  NH1  B ARG A 1 61  ? -12.77800 -20.11000 14.68400  0.590 46.03136 ? 61  ARG A NH1  1 
ATOM   1170 N  NH2  A ARG A 1 61  ? -10.39700 -21.36800 17.94200  0.410 46.54053 ? 61  ARG A NH2  1 
ATOM   1171 N  NH2  B ARG A 1 61  ? -14.17000 -20.37900 12.88100  0.590 33.60952 ? 61  ARG A NH2  1 
ATOM   1172 H  H    A ARG A 1 61  ? -8.91100  -19.02300 10.21700  0.530 24.01641 ? 61  ARG A H    1 
ATOM   1173 H  H    B ARG A 1 61  ? -8.91300  -19.08800 10.26000  0.470 24.43181 ? 61  ARG A H    1 
ATOM   1174 H  HA   A ARG A 1 61  ? -9.75200  -18.46800 12.62500  0.410 27.48124 ? 61  ARG A HA   1 
ATOM   1175 H  HA   B ARG A 1 61  ? -9.75200  -18.47200 12.70600  0.590 27.14921 ? 61  ARG A HA   1 
ATOM   1176 H  HB2  A ARG A 1 61  ? -10.54700 -20.39100 11.64500  0.410 35.67449 ? 61  ARG A HB2  1 
ATOM   1177 H  HB2  B ARG A 1 61  ? -10.35900 -20.49400 11.68700  0.590 34.83176 ? 61  ARG A HB2  1 
ATOM   1178 H  HB3  A ARG A 1 61  ? -9.08200  -21.00700 11.59900  0.410 35.67449 ? 61  ARG A HB3  1 
ATOM   1179 H  HB3  B ARG A 1 61  ? -8.85300  -20.98600 11.80700  0.590 34.83176 ? 61  ARG A HB3  1 
ATOM   1180 H  HG2  A ARG A 1 61  ? -10.45500 -21.93400 13.34300  0.410 46.34581 ? 61  ARG A HG2  1 
ATOM   1181 H  HG2  B ARG A 1 61  ? -9.05200  -21.48100 13.92700  0.590 46.32137 ? 61  ARG A HG2  1 
ATOM   1182 H  HG3  A ARG A 1 61  ? -9.07900  -21.34500 13.87700  0.410 46.34581 ? 61  ARG A HG3  1 
ATOM   1183 H  HG3  B ARG A 1 61  ? -10.09500 -20.31200 14.19800  0.590 46.32137 ? 61  ARG A HG3  1 
ATOM   1184 H  HD2  A ARG A 1 61  ? -10.19500 -19.41400 14.59700  0.410 44.44639 ? 61  ARG A HD2  1 
ATOM   1185 H  HD2  B ARG A 1 61  ? -10.70400 -22.85100 13.13900  0.590 45.59395 ? 61  ARG A HD2  1 
ATOM   1186 H  HD3  A ARG A 1 61  ? -11.56900 -20.02500 14.08300  0.410 44.44639 ? 61  ARG A HD3  1 
ATOM   1187 H  HD3  B ARG A 1 61  ? -11.19400 -22.28000 14.53800  0.590 45.59395 ? 61  ARG A HD3  1 
ATOM   1188 H  HE   A ARG A 1 61  ? -11.63900 -21.29700 15.88100  0.410 56.14212 ? 61  ARG A HE   1 
ATOM   1189 H  HE   B ARG A 1 61  ? -12.43500 -21.91900 12.22700  0.590 50.75120 ? 61  ARG A HE   1 
ATOM   1190 H  HH11 A ARG A 1 61  ? -8.68600  -19.77000 15.96200  0.410 49.17081 ? 61  ARG A HH11 1 
ATOM   1191 H  HH11 B ARG A 1 61  ? -13.32400 -19.53200 15.01100  0.590 55.24120 ? 61  ARG A HH11 1 
ATOM   1192 H  HH12 A ARG A 1 61  ? -8.38100  -20.12000 17.37700  0.410 49.17081 ? 61  ARG A HH12 1 
ATOM   1193 H  HH12 B ARG A 1 61  ? -12.05800 -20.31000 15.10900  0.590 55.24120 ? 61  ARG A HH12 1 
ATOM   1194 H  HH21 A ARG A 1 61  ? -11.14700 -21.78300 18.01500  0.410 55.85221 ? 61  ARG A HH21 1 
ATOM   1195 H  HH21 B ARG A 1 61  ? -14.35500 -20.75500 12.13000  0.590 40.33499 ? 61  ARG A HH21 1 
ATOM   1196 H  HH22 A ARG A 1 61  ? -9.85900  -21.33000 18.61200  0.410 55.85221 ? 61  ARG A HH22 1 
ATOM   1197 H  HH22 B ARG A 1 61  ? -14.71000 -19.80000 13.21700  0.590 40.33499 ? 61  ARG A HH22 1 
ATOM   1198 N  N    A TRP A 1 62  ? -6.66300  -19.16400 12.39500  0.660 21.70837 ? 62  TRP A N    1 
ATOM   1199 N  N    B TRP A 1 62  ? -6.64600  -19.13100 12.35800  0.340 21.83393 ? 62  TRP A N    1 
ATOM   1200 C  CA   A TRP A 1 62  ? -5.38800  -19.21000 13.10700  0.660 23.16704 ? 62  TRP A CA   1 
ATOM   1201 C  CA   B TRP A 1 62  ? -5.38600  -19.25100 13.07300  0.340 23.27912 ? 62  TRP A CA   1 
ATOM   1202 C  C    A TRP A 1 62  ? -4.42700  -18.09000 12.75500  0.660 22.30149 ? 62  TRP A C    1 
ATOM   1203 C  C    B TRP A 1 62  ? -4.32800  -18.22900 12.69900  0.340 23.18935 ? 62  TRP A C    1 
ATOM   1204 O  O    A TRP A 1 62  ? -3.74200  -17.58800 13.63900  0.660 24.08708 ? 62  TRP A O    1 
ATOM   1205 O  O    B TRP A 1 62  ? -3.46900  -17.94700 13.52600  0.340 20.58093 ? 62  TRP A O    1 
ATOM   1206 C  CB   A TRP A 1 62  ? -4.66200  -20.54300 12.85800  0.660 26.06903 ? 62  TRP A CB   1 
ATOM   1207 C  CB   B TRP A 1 62  ? -4.80300  -20.66400 12.88900  0.340 27.08636 ? 62  TRP A CB   1 
ATOM   1208 C  CG   A TRP A 1 62  ? -5.51800  -21.70300 13.12800  0.660 29.88662 ? 62  TRP A CG   1 
ATOM   1209 C  CG   B TRP A 1 62  ? -5.75900  -21.72800 13.32400  0.340 31.71546 ? 62  TRP A CG   1 
ATOM   1210 C  CD1  A TRP A 1 62  ? -6.22300  -22.43400 12.22200  0.660 32.82970 ? 62  TRP A CD1  1 
ATOM   1211 C  CD1  B TRP A 1 62  ? -6.51100  -22.53500 12.52200  0.340 34.52320 ? 62  TRP A CD1  1 
ATOM   1212 C  CD2  A TRP A 1 62  ? -5.78700  -22.27300 14.40700  0.660 40.80691 ? 62  TRP A CD2  1 
ATOM   1213 C  CD2  B TRP A 1 62  ? -6.08700  -22.08500 14.67400  0.340 38.88078 ? 62  TRP A CD2  1 
ATOM   1214 N  NE1  A TRP A 1 62  ? -6.92000  -23.42800 12.85900  0.660 45.61624 ? 62  TRP A NE1  1 
ATOM   1215 N  NE1  B TRP A 1 62  ? -7.28400  -23.37500 13.28700  0.340 42.16342 ? 62  TRP A NE1  1 
ATOM   1216 C  CE2  A TRP A 1 62  ? -6.66700  -23.35200 14.20400  0.660 38.76564 ? 62  TRP A CE2  1 
ATOM   1217 C  CE2  B TRP A 1 62  ? -7.03900  -23.12200 14.61000  0.340 42.59382 ? 62  TRP A CE2  1 
ATOM   1218 C  CE3  A TRP A 1 62  ? -5.36800  -21.97600 15.70700  0.660 42.71772 ? 62  TRP A CE3  1 
ATOM   1219 C  CE3  B TRP A 1 62  ? -5.66500  -21.63200 15.92700  0.340 42.56513 ? 62  TRP A CE3  1 
ATOM   1220 C  CZ2  A TRP A 1 62  ? -7.13400  -24.14000 15.25200  0.660 57.91556 ? 62  TRP A CZ2  1 
ATOM   1221 C  CZ2  B TRP A 1 62  ? -7.57700  -23.71400 15.75100  0.340 52.80679 ? 62  TRP A CZ2  1 
ATOM   1222 C  CZ3  A TRP A 1 62  ? -5.82900  -22.75800 16.74500  0.660 52.33501 ? 62  TRP A CZ3  1 
ATOM   1223 C  CZ3  B TRP A 1 62  ? -6.19900  -22.22300 17.06000  0.340 52.40507 ? 62  TRP A CZ3  1 
ATOM   1224 C  CH2  A TRP A 1 62  ? -6.70600  -23.82700 16.51300  0.660 55.65895 ? 62  TRP A CH2  1 
ATOM   1225 C  CH2  B TRP A 1 62  ? -7.14600  -23.25200 16.96400  0.340 52.34274 ? 62  TRP A CH2  1 
ATOM   1226 H  H    A TRP A 1 62  ? -6.58200  -19.18000 11.53900  0.410 26.05361 ? 62  TRP A H    1 
ATOM   1227 H  H    B TRP A 1 62  ? -6.59300  -19.25500 11.50900  0.590 26.20428 ? 62  TRP A H    1 
ATOM   1228 H  HA   A TRP A 1 62  ? -5.60000  -19.14100 14.05100  0.660 27.80402 ? 62  TRP A HA   1 
ATOM   1229 H  HA   B TRP A 1 62  ? -5.57000  -19.11800 14.01600  0.340 27.93851 ? 62  TRP A HA   1 
ATOM   1230 H  HB2  A TRP A 1 62  ? -4.38200  -20.58400 11.93000  0.660 31.28640 ? 62  TRP A HB2  1 
ATOM   1231 H  HB2  B TRP A 1 62  ? -4.60000  -20.80500 11.95100  0.340 32.50720 ? 62  TRP A HB2  1 
ATOM   1232 H  HB3  A TRP A 1 62  ? -3.88700  -20.59700 13.44000  0.660 31.28640 ? 62  TRP A HB3  1 
ATOM   1233 H  HB3  B TRP A 1 62  ? -3.99500  -20.74700 13.41900  0.340 32.50720 ? 62  TRP A HB3  1 
ATOM   1234 H  HD1  A TRP A 1 62  ? -6.23200  -22.28100 11.30500  0.660 39.39921 ? 62  TRP A HD1  1 
ATOM   1235 H  HD1  B TRP A 1 62  ? -6.50100  -22.51900 11.59200  0.340 41.43141 ? 62  TRP A HD1  1 
ATOM   1236 H  HE1  A TRP A 1 62  ? -7.43100  -24.00500 12.47800  0.660 54.74306 ? 62  TRP A HE1  1 
ATOM   1237 H  HE1  B TRP A 1 62  ? -7.83200  -23.96400 12.98300  0.340 50.59967 ? 62  TRP A HE1  1 
ATOM   1238 H  HE3  A TRP A 1 62  ? -4.79100  -21.26500 15.86900  0.660 51.26483 ? 62  TRP A HE3  1 
ATOM   1239 H  HE3  B TRP A 1 62  ? -5.03900  -20.94900 15.99900  0.340 51.08172 ? 62  TRP A HE3  1 
ATOM   1240 H  HZ2  A TRP A 1 62  ? -7.71300  -24.85100 15.10100  0.660 69.50224 ? 62  TRP A HZ2  1 
ATOM   1241 H  HZ2  B TRP A 1 62  ? -8.20600  -24.39600 15.69100  0.340 63.37172 ? 62  TRP A HZ2  1 
ATOM   1242 H  HZ3  A TRP A 1 62  ? -5.55400  -22.57400 17.61400  0.660 62.80558 ? 62  TRP A HZ3  1 
ATOM   1243 H  HZ3  B TRP A 1 62  ? -5.92500  -21.93100 17.90000  0.340 62.88965 ? 62  TRP A HZ3  1 
ATOM   1244 H  HH2  A TRP A 1 62  ? -7.00400  -24.33500 17.23300  0.660 66.79431 ? 62  TRP A HH2  1 
ATOM   1245 H  HH2  B TRP A 1 62  ? -7.48800  -23.62900 17.74200  0.340 62.81486 ? 62  TRP A HH2  1 
ATOM   1246 N  N    . TRP A 1 63  ? -4.32800  -17.69000 11.47800  1.000 18.59923 ? 63  TRP A N    1 
ATOM   1247 C  CA   . TRP A 1 63  ? -3.14800  -17.02600 10.97400  1.000 17.29705 ? 63  TRP A CA   1 
ATOM   1248 C  C    . TRP A 1 63  ? -3.23300  -15.54200 10.70500  1.000 18.38336 ? 63  TRP A C    1 
ATOM   1249 O  O    . TRP A 1 63  ? -2.20200  -14.87500 10.72100  1.000 20.10467 ? 63  TRP A O    1 
ATOM   1250 C  CB   . TRP A 1 63  ? -2.67300  -17.76300 9.68400   1.000 18.18390 ? 63  TRP A CB   1 
ATOM   1251 C  CG   . TRP A 1 63  ? -2.47300  -19.24100 9.95000   1.000 21.09718 ? 63  TRP A CG   1 
ATOM   1252 C  CD1  . TRP A 1 63  ? -3.26900  -20.26000 9.54500   1.000 23.06921 ? 63  TRP A CD1  1 
ATOM   1253 C  CD2  . TRP A 1 63  ? -1.44600  -19.82800 10.76300  1.000 21.50423 ? 63  TRP A CD2  1 
ATOM   1254 N  NE1  . TRP A 1 63  ? -2.80000  -21.46000 10.03500  1.000 24.10017 ? 63  TRP A NE1  1 
ATOM   1255 C  CE2  . TRP A 1 63  ? -1.68900  -21.22000 10.79300  1.000 20.16088 ? 63  TRP A CE2  1 
ATOM   1256 C  CE3  . TRP A 1 63  ? -0.34800  -19.31500 11.45600  1.000 21.37620 ? 63  TRP A CE3  1 
ATOM   1257 C  CZ2  . TRP A 1 63  ? -0.83400  -22.12000 11.47800  1.000 21.34760 ? 63  TRP A CZ2  1 
ATOM   1258 C  CZ3  . TRP A 1 63  ? 0.50600   -20.22600 12.14800  1.000 22.76400 ? 63  TRP A CZ3  1 
ATOM   1259 C  CH2  . TRP A 1 63  ? 0.24200   -21.59600 12.13500  1.000 24.56041 ? 63  TRP A CH2  1 
ATOM   1260 H  H    . TRP A 1 63  ? -4.94400  -17.79800 10.88700  1.000 22.32264 ? 63  TRP A H    1 
ATOM   1261 H  HA   . TRP A 1 63  ? -2.46900  -17.09100 11.66400  1.000 20.76003 ? 63  TRP A HA   1 
ATOM   1262 H  HB2  . TRP A 1 63  ? -3.34200  -17.66200 8.98900   1.000 21.82425 ? 63  TRP A HB2  1 
ATOM   1263 H  HB3  . TRP A 1 63  ? -1.82900  -17.38600 9.38900   1.000 21.82425 ? 63  TRP A HB3  1 
ATOM   1264 H  HD1  . TRP A 1 63  ? -4.02500  -20.16400 9.01200   1.000 27.68662 ? 63  TRP A HD1  1 
ATOM   1265 H  HE1  . TRP A 1 63  ? -3.14800  -22.23200 9.88700   1.000 28.92378 ? 63  TRP A HE1  1 
ATOM   1266 H  HE3  . TRP A 1 63  ? -0.17600  -18.40100 11.46600  1.000 25.65501 ? 63  TRP A HE3  1 
ATOM   1267 H  HZ2  . TRP A 1 63  ? -1.00000  -23.03500 11.47900  1.000 25.62069 ? 63  TRP A HZ2  1 
ATOM   1268 H  HZ3  . TRP A 1 63  ? 1.24500   -19.90300 12.61200  1.000 27.32037 ? 63  TRP A HZ3  1 
ATOM   1269 H  HH2  . TRP A 1 63  ? 0.81600   -22.17000 12.58900  1.000 29.47606 ? 63  TRP A HH2  1 
ATOM   1270 N  N    . CYS A 1 64  ? -4.41400  -15.01100 10.42500  1.000 19.42145 ? 64  CYS A N    1 
ATOM   1271 C  CA   . CYS A 1 64  ? -4.57800  -13.60300 10.10400  1.000 19.11050 ? 64  CYS A CA   1 
ATOM   1272 C  C    . CYS A 1 64  ? -5.91900  -13.12900 10.63500  1.000 19.51188 ? 64  CYS A C    1 
ATOM   1273 O  O    . CYS A 1 64  ? -6.81000  -13.91600 10.93300  1.000 21.24597 ? 64  CYS A O    1 
ATOM   1274 C  CB   . CYS A 1 64  ? -4.48100  -13.36200 8.59100   1.000 18.95170 ? 64  CYS A CB   1 
ATOM   1275 S  SG   . CYS A 1 64  ? -5.74500  -14.16100 7.56600   1.000 18.34541 ? 64  CYS A SG   1 
ATOM   1276 H  H    . CYS A 1 64  ? -5.15100  -15.45400 10.41500  1.000 23.30931 ? 64  CYS A H    1 
ATOM   1277 H  HA   . CYS A 1 64  ? -3.88300  -13.08600 10.54000  1.000 22.93617 ? 64  CYS A HA   1 
ATOM   1278 H  HB2  . CYS A 1 64  ? -4.54700  -12.40700 8.43300   1.000 22.74561 ? 64  CYS A HB2  1 
ATOM   1279 H  HB3  . CYS A 1 64  ? -3.61900  -13.69000 8.28800   1.000 22.74561 ? 64  CYS A HB3  1 
ATOM   1280 N  N    . ASN A 1 65  ? -6.04700  -11.81500 10.76100  1.000 19.98851 ? 65  ASN A N    1 
ATOM   1281 C  CA   . ASN A 1 65  ? -7.27900  -11.22000 11.26800  1.000 20.67576 ? 65  ASN A CA   1 
ATOM   1282 C  C    . ASN A 1 65  ? -8.10900  -10.61200 10.14700  1.000 17.99701 ? 65  ASN A C    1 
ATOM   1283 O  O    . ASN A 1 65  ? -7.61800  -9.73600  9.44300   1.000 19.09983 ? 65  ASN A O    1 
ATOM   1284 C  CB   . ASN A 1 65  ? -6.94300  -10.13100 12.26900  1.000 23.95369 ? 65  ASN A CB   1 
ATOM   1285 C  CG   . ASN A 1 65  ? -8.17400  -9.45100  12.78300  1.000 32.80711 ? 65  ASN A CG   1 
ATOM   1286 O  OD1  . ASN A 1 65  ? -9.10100  -10.11900 13.21600  1.000 32.73997 ? 65  ASN A OD1  1 
ATOM   1287 N  ND2  . ASN A 1 65  ? -8.21300  -8.12600  12.69500  1.000 43.97161 ? 65  ASN A ND2  1 
ATOM   1288 H  H    . ASN A 1 65  ? -5.43500  -11.24600 10.56000  1.000 23.98978 ? 65  ASN A H    1 
ATOM   1289 H  HA   . ASN A 1 65  ? -7.80600  -11.92500 11.67600  1.000 24.81449 ? 65  ASN A HA   1 
ATOM   1290 H  HB2  . ASN A 1 65  ? -6.47400  -10.52200 13.02300  1.000 28.74799 ? 65  ASN A HB2  1 
ATOM   1291 H  HB3  . ASN A 1 65  ? -6.38300  -9.46400  11.84100  1.000 28.74799 ? 65  ASN A HB3  1 
ATOM   1292 H  HD21 . ASN A 1 65  ? -7.54900  -7.69900  12.35500  1.000 52.76950 ? 65  ASN A HD21 1 
ATOM   1293 H  HD22 . ASN A 1 65  ? -8.90100  -7.69700  12.97900  1.000 52.76950 ? 65  ASN A HD22 1 
ATOM   1294 N  N    . ASP A 1 66  ? -9.35800  -11.06600 10.01900  1.000 17.94212 ? 66  ASP A N    1 
ATOM   1295 C  CA   . ASP A 1 66  ? -10.28000 -10.50500 9.02900   1.000 17.68282 ? 66  ASP A CA   1 
ATOM   1296 C  C    . ASP A 1 66  ? -11.47000 -9.81600  9.66100   1.000 20.18622 ? 66  ASP A C    1 
ATOM   1297 O  O    . ASP A 1 66  ? -12.34500 -9.34700  8.92800   1.000 21.68153 ? 66  ASP A O    1 
ATOM   1298 C  CB   . ASP A 1 66  ? -10.74100 -11.51800 7.97900   1.000 19.22824 ? 66  ASP A CB   1 
ATOM   1299 C  CG   . ASP A 1 66  ? -11.57600 -12.65300 8.52300   1.000 17.59256 ? 66  ASP A CG   1 
ATOM   1300 O  OD1  . ASP A 1 66  ? -11.94900 -12.67700 9.72700   1.000 18.74347 ? 66  ASP A OD1  1 
ATOM   1301 O  OD2  . ASP A 1 66  ? -11.93000 -13.53600 7.71700   1.000 18.07797 ? 66  ASP A OD2  1 
ATOM   1302 H  H    . ASP A 1 66  ? -9.69500  -11.69800 10.49500  1.000 21.53411 ? 66  ASP A H    1 
ATOM   1303 H  HA   . ASP A 1 66  ? -9.77400  -9.84300  8.53400   1.000 21.22295 ? 66  ASP A HA   1 
ATOM   1304 H  HB2  . ASP A 1 66  ? -11.27600 -11.05300 7.31700   1.000 23.07746 ? 66  ASP A HB2  1 
ATOM   1305 H  HB3  . ASP A 1 66  ? -9.95700  -11.90600 7.56000   1.000 23.07746 ? 66  ASP A HB3  1 
ATOM   1306 N  N    . GLY A 1 67  ? -11.47800 -9.67800  10.97700  1.000 21.09613 ? 67  GLY A N    1 
ATOM   1307 C  CA   . GLY A 1 67  ? -12.52800 -8.95700  11.68800  1.000 23.84449 ? 67  GLY A CA   1 
ATOM   1308 C  C    . GLY A 1 67  ? -13.85900 -9.65100  11.77200  1.000 26.07857 ? 67  GLY A C    1 
ATOM   1309 O  O    . GLY A 1 67  ? -14.81100 -9.07300  12.32100  1.000 31.99224 ? 67  GLY A O    1 
ATOM   1310 H  H    . GLY A 1 67  ? -10.87400 -10.00100 11.49700  1.000 25.31892 ? 67  GLY A H    1 
ATOM   1311 H  HA2  . GLY A 1 67  ? -12.22700 -8.79300  12.59500  1.000 28.61696 ? 67  GLY A HA2  1 
ATOM   1312 H  HA3  . GLY A 1 67  ? -12.67000 -8.10600  11.24400  1.000 28.61696 ? 67  GLY A HA3  1 
ATOM   1313 N  N    A ARG A 1 68  ? -13.98800 -10.87200 11.25900  0.770 19.51079 ? 68  ARG A N    1 
ATOM   1314 N  N    B ARG A 1 68  ? -13.97000 -10.87900 11.26800  0.230 19.87340 ? 68  ARG A N    1 
ATOM   1315 C  CA   A ARG A 1 68  ? -15.27000 -11.55900 11.29500  0.770 20.51183 ? 68  ARG A CA   1 
ATOM   1316 C  CA   B ARG A 1 68  ? -15.24900 -11.57600 11.24400  0.230 20.63024 ? 68  ARG A CA   1 
ATOM   1317 C  C    A ARG A 1 68  ? -15.14800 -13.03400 11.64800  0.770 24.37511 ? 68  ARG A C    1 
ATOM   1318 C  C    B ARG A 1 68  ? -15.09400 -13.06200 11.54200  0.230 24.19071 ? 68  ARG A C    1 
ATOM   1319 O  O    A ARG A 1 68  ? -16.10400 -13.78700 11.44200  0.770 26.97642 ? 68  ARG A O    1 
ATOM   1320 O  O    B ARG A 1 68  ? -15.94900 -13.86100 11.14000  0.230 26.77806 ? 68  ARG A O    1 
ATOM   1321 C  CB   A ARG A 1 68  ? -16.00100 -11.36700 9.96800   0.770 22.11150 ? 68  ARG A CB   1 
ATOM   1322 C  CB   B ARG A 1 68  ? -15.92700 -11.36200 9.89000   0.230 22.23234 ? 68  ARG A CB   1 
ATOM   1323 C  CG   A ARG A 1 68  ? -15.36900 -12.10400 8.81100   0.770 21.47539 ? 68  ARG A CG   1 
ATOM   1324 C  CG   B ARG A 1 68  ? -15.05800 -11.74500 8.70300   0.230 25.81767 ? 68  ARG A CG   1 
ATOM   1325 C  CD   A ARG A 1 68  ? -16.29700 -12.10100 7.63200   0.770 23.80739 ? 68  ARG A CD   1 
ATOM   1326 C  CD   B ARG A 1 68  ? -15.89500 -12.34700 7.58700   0.230 25.35352 ? 68  ARG A CD   1 
ATOM   1327 N  NE   A ARG A 1 68  ? -15.84300 -13.03800 6.61600   0.770 20.79482 ? 68  ARG A NE   1 
ATOM   1328 N  NE   B ARG A 1 68  ? -16.34500 -13.69500 7.92000   0.230 29.53262 ? 68  ARG A NE   1 
ATOM   1329 C  CZ   A ARG A 1 68  ? -16.27200 -13.03200 5.35900   0.770 21.78950 ? 68  ARG A CZ   1 
ATOM   1330 C  CZ   B ARG A 1 68  ? -17.56700 -14.16200 7.69700   0.230 30.78298 ? 68  ARG A CZ   1 
ATOM   1331 N  NH1  A ARG A 1 68  ? -17.16700 -12.15100 4.94800   0.770 23.77829 ? 68  ARG A NH1  1 
ATOM   1332 N  NH1  B ARG A 1 68  ? -18.50000 -13.42200 7.12000   0.230 31.12114 ? 68  ARG A NH1  1 
ATOM   1333 N  NH2  A ARG A 1 68  ? -15.81100 -13.94900 4.50200   0.770 20.51051 ? 68  ARG A NH2  1 
ATOM   1334 N  NH2  B ARG A 1 68  ? -17.86200 -15.40400 8.06200   0.230 15.74502 ? 68  ARG A NH2  1 
ATOM   1335 H  H    A ARG A 1 68  ? -13.35300 -11.31900 10.89000  0.770 23.41652 ? 68  ARG A H    1 
ATOM   1336 H  H    B ARG A 1 68  ? -13.31800 -11.32900 10.93400  0.230 23.85165 ? 68  ARG A H    1 
ATOM   1337 H  HA   A ARG A 1 68  ? -15.81600 -11.16900 11.99600  0.770 24.61777 ? 68  ARG A HA   1 
ATOM   1338 H  HA   B ARG A 1 68  ? -15.83100 -11.21600 11.93100  0.230 24.75986 ? 68  ARG A HA   1 
ATOM   1339 H  HB2  A ARG A 1 68  ? -16.91000 -11.69000 10.06300  0.770 26.53737 ? 68  ARG A HB2  1 
ATOM   1340 H  HB2  B ARG A 1 68  ? -16.73100 -11.90400 9.85500   0.230 26.68237 ? 68  ARG A HB2  1 
ATOM   1341 H  HB3  A ARG A 1 68  ? -16.00600 -10.42200 9.74900   0.770 26.53737 ? 68  ARG A HB3  1 
ATOM   1342 H  HB3  B ARG A 1 68  ? -16.15500 -10.42400 9.80000   0.230 26.68237 ? 68  ARG A HB3  1 
ATOM   1343 H  HG2  A ARG A 1 68  ? -14.54200 -11.66600 8.55700   0.770 25.77404 ? 68  ARG A HG2  1 
ATOM   1344 H  HG2  B ARG A 1 68  ? -14.61200 -10.95500 8.36000   0.230 30.98477 ? 68  ARG A HG2  1 
ATOM   1345 H  HG3  A ARG A 1 68  ? -15.19300 -13.02300 9.06600   0.770 25.77404 ? 68  ARG A HG3  1 
ATOM   1346 H  HG3  B ARG A 1 68  ? -14.40100 -12.40200 8.98200   0.230 30.98477 ? 68  ARG A HG3  1 
ATOM   1347 H  HD2  A ARG A 1 68  ? -17.18600 -12.36300 7.91800   0.770 28.57243 ? 68  ARG A HD2  1 
ATOM   1348 H  HD2  B ARG A 1 68  ? -16.67800 -11.79300 7.43900   0.230 30.42779 ? 68  ARG A HD2  1 
ATOM   1349 H  HD3  A ARG A 1 68  ? -16.32300 -11.21300 7.24200   0.770 28.57243 ? 68  ARG A HD3  1 
ATOM   1350 H  HD3  B ARG A 1 68  ? -15.36400 -12.39400 6.77700   0.230 30.42779 ? 68  ARG A HD3  1 
ATOM   1351 H  HE   A ARG A 1 68  ? -15.26200 -13.63100 6.84300   0.770 24.95735 ? 68  ARG A HE   1 
ATOM   1352 H  HE   B ARG A 1 68  ? -15.77600 -14.22500 8.28700   0.230 35.44271 ? 68  ARG A HE   1 
ATOM   1353 H  HH11 A ARG A 1 68  ? -17.48100 -11.56900 5.49700   0.770 28.53751 ? 68  ARG A HH11 1 
ATOM   1354 H  HH11 B ARG A 1 68  ? -18.32000 -12.61600 6.87900   0.230 37.34894 ? 68  ARG A HH11 1 
ATOM   1355 H  HH12 A ARG A 1 68  ? -17.43500 -12.16100 4.13100   0.770 28.53751 ? 68  ARG A HH12 1 
ATOM   1356 H  HH12 B ARG A 1 68  ? -19.28500 -13.74600 6.98600   0.230 37.34894 ? 68  ARG A HH12 1 
ATOM   1357 H  HH21 A ARG A 1 68  ? -15.24100 -14.53600 4.76500   0.770 24.61618 ? 68  ARG A HH21 1 
ATOM   1358 H  HH21 B ARG A 1 68  ? -17.26400 -15.89500 8.43800   0.230 18.89760 ? 68  ARG A HH21 1 
ATOM   1359 H  HH22 A ARG A 1 68  ? -16.08500 -13.95100 3.68700   0.770 24.61618 ? 68  ARG A HH22 1 
ATOM   1360 H  HH22 B ARG A 1 68  ? -18.65000 -15.71800 7.92300   0.230 18.89760 ? 68  ARG A HH22 1 
ATOM   1361 N  N    . THR A 1 69  ? -14.01600 -13.46000 12.21800  1.000 20.63701 ? 69  THR A N    1 
ATOM   1362 C  CA   . THR A 1 69  ? -13.79700 -14.84900 12.61400  1.000 19.48552 ? 69  THR A CA   1 
ATOM   1363 C  C    . THR A 1 69  ? -13.66100 -14.88100 14.13200  1.000 22.93185 ? 69  THR A C    1 
ATOM   1364 O  O    . THR A 1 69  ? -12.57100 -14.69000 14.66100  1.000 26.23592 ? 69  THR A O    1 
ATOM   1365 C  CB   . THR A 1 69  ? -12.55900 -15.43500 11.92000  1.000 20.90542 ? 69  THR A CB   1 
ATOM   1366 O  OG1  . THR A 1 69  ? -12.61700 -15.16600 10.50300  1.000 20.52567 ? 69  THR A OG1  1 
ATOM   1367 C  CG2  . THR A 1 69  ? -12.52100 -16.93900 12.10000  1.000 21.97717 ? 69  THR A CG2  1 
ATOM   1368 H  H    . THR A 1 69  ? -13.34500 -12.95000 12.39000  1.000 24.76798 ? 69  THR A H    1 
ATOM   1369 H  HA   . THR A 1 69  ? -14.56000 -15.39000 12.36100  1.000 23.38620 ? 69  THR A HA   1 
ATOM   1370 H  HB   . THR A 1 69  ? -11.76400 -15.03500 12.30700  1.000 25.09008 ? 69  THR A HB   1 
ATOM   1371 H  HG1  . THR A 1 69  ? -13.27100 -15.56600 10.16100  1.000 24.63437 ? 69  THR A HG1  1 
ATOM   1372 H  HG21 . THR A 1 69  ? -11.72000 -17.30100 11.69200  1.000 26.37617 ? 69  THR A HG21 1 
ATOM   1373 H  HG22 . THR A 1 69  ? -12.52200 -17.16000 13.04400  1.000 26.37617 ? 69  THR A HG22 1 
ATOM   1374 H  HG23 . THR A 1 69  ? -13.29800 -17.34200 11.68100  1.000 26.37617 ? 69  THR A HG23 1 
ATOM   1375 N  N    . PRO A 1 70  ? -14.75500 -15.05700 14.86700  1.000 27.39764 ? 70  PRO A N    1 
ATOM   1376 C  CA   . PRO A 1 70  ? -14.68300 -14.89900 16.32700  1.000 46.86102 ? 70  PRO A CA   1 
ATOM   1377 C  C    . PRO A 1 70  ? -13.74000 -15.91100 16.95400  1.000 43.85196 ? 70  PRO A C    1 
ATOM   1378 O  O    . PRO A 1 70  ? -13.64400 -17.05900 16.51800  1.000 37.73037 ? 70  PRO A O    1 
ATOM   1379 C  CB   . PRO A 1 70  ? -16.13200 -15.12300 16.78200  1.000 54.76397 ? 70  PRO A CB   1 
ATOM   1380 C  CG   . PRO A 1 70  ? -16.95700 -14.83200 15.57100  1.000 50.23678 ? 70  PRO A CG   1 
ATOM   1381 C  CD   . PRO A 1 70  ? -16.13100 -15.33500 14.42000  1.000 36.55147 ? 70  PRO A CD   1 
ATOM   1382 H  HA   . PRO A 1 70  ? -14.39800 -14.00200 16.55900  1.000 56.23680 ? 70  PRO A HA   1 
ATOM   1383 H  HB2  . PRO A 1 70  ? -16.25100 -16.04200 17.07100  1.000 65.72033 ? 70  PRO A HB2  1 
ATOM   1384 H  HB3  . PRO A 1 70  ? -16.35000 -14.51600 17.50600  1.000 65.72033 ? 70  PRO A HB3  1 
ATOM   1385 H  HG2  . PRO A 1 70  ? -17.80300 -15.30300 15.62400  1.000 60.28771 ? 70  PRO A HG2  1 
ATOM   1386 H  HG3  . PRO A 1 70  ? -17.11300 -13.87800 15.49700  1.000 60.28771 ? 70  PRO A HG3  1 
ATOM   1387 H  HD2  . PRO A 1 70  ? -16.26700 -16.28500 14.28300  1.000 43.86534 ? 70  PRO A HD2  1 
ATOM   1388 H  HD3  . PRO A 1 70  ? -16.33700 -14.85000 13.60600  1.000 43.86534 ? 70  PRO A HD3  1 
ATOM   1389 N  N    A GLY A 1 71  ? -13.08200 -15.48200 18.03000  0.510 46.70354 ? 71  GLY A N    1 
ATOM   1390 N  N    B GLY A 1 71  ? -12.99100 -15.45600 17.95300  0.490 46.66372 ? 71  GLY A N    1 
ATOM   1391 C  CA   A GLY A 1 71  ? -12.19600 -16.34700 18.77700  0.510 56.96308 ? 71  GLY A CA   1 
ATOM   1392 C  CA   B GLY A 1 71  ? -11.98000 -16.29600 18.56200  0.490 55.23250 ? 71  GLY A CA   1 
ATOM   1393 C  C    A GLY A 1 71  ? -10.96500 -16.78800 18.02900  0.510 48.11013 ? 71  GLY A C    1 
ATOM   1394 C  C    B GLY A 1 71  ? -10.93700 -16.77700 17.57200  0.490 45.28924 ? 71  GLY A C    1 
ATOM   1395 O  O    A GLY A 1 71  ? -10.12300 -17.49000 18.60500  0.510 48.85815 ? 71  GLY A O    1 
ATOM   1396 O  O    B GLY A 1 71  ? -10.82400 -17.98100 17.32100  0.490 53.51008 ? 71  GLY A O    1 
ATOM   1397 H  H    A GLY A 1 71  ? -13.13800 -14.68300 18.34400  0.510 56.04782 ? 71  GLY A H    1 
ATOM   1398 H  H    B GLY A 1 71  ? -13.05200 -14.66700 18.29100  0.490 56.00003 ? 71  GLY A H    1 
ATOM   1399 H  HA2  A GLY A 1 71  ? -11.90600 -15.87800 19.57500  0.510 68.35927 ? 71  GLY A HA2  1 
ATOM   1400 H  HA2  B GLY A 1 71  ? -11.52800 -15.79700 19.26000  0.490 66.28257 ? 71  GLY A HA2  1 
ATOM   1401 H  HA3  A GLY A 1 71  ? -12.68600 -17.14200 19.03800  0.510 68.35927 ? 71  GLY A HA3  1 
ATOM   1402 H  HA3  B GLY A 1 71  ? -12.40600 -17.07400 18.95600  0.490 66.28257 ? 71  GLY A HA3  1 
ATOM   1403 N  N    A SER A 1 72  ? -10.81900 -16.39200 16.77200  0.500 33.00651 ? 72  SER A N    1 
ATOM   1404 N  N    B SER A 1 72  ? -10.16900 -15.84400 17.00200  0.500 28.60133 ? 72  SER A N    1 
ATOM   1405 C  CA   A SER A 1 72  ? -9.69100  -16.85500 15.99700  0.500 37.55498 ? 72  SER A CA   1 
ATOM   1406 C  CA   B SER A 1 72  ? -9.11300  -16.14900 16.04600  0.500 38.33999 ? 72  SER A CA   1 
ATOM   1407 C  C    A SER A 1 72  ? -8.40300  -16.26000 16.55500  0.500 39.91635 ? 72  SER A C    1 
ATOM   1408 C  C    B SER A 1 72  ? -7.76500  -15.65600 16.56200  0.500 25.06252 ? 72  SER A C    1 
ATOM   1409 O  O    A SER A 1 72  ? -8.40400  -15.36700 17.41400  0.500 30.77494 ? 72  SER A O    1 
ATOM   1410 O  O    B SER A 1 72  ? -7.65900  -14.55700 17.12000  0.500 25.78889 ? 72  SER A O    1 
ATOM   1411 C  CB   A SER A 1 72  ? -9.86600  -16.47400 14.52900  0.500 32.55415 ? 72  SER A CB   1 
ATOM   1412 C  CB   B SER A 1 72  ? -9.42600  -15.53000 14.68700  0.500 31.47581 ? 72  SER A CB   1 
ATOM   1413 O  OG   A SER A 1 72  ? -9.87500  -15.06700 14.36900  0.500 32.15762 ? 72  SER A OG   1 
ATOM   1414 O  OG   B SER A 1 72  ? -8.73800  -14.30900 14.51400  0.500 35.79857 ? 72  SER A OG   1 
ATOM   1415 H  H    A SER A 1 72  ? -11.35500 -15.86400 16.35500  0.500 39.61138 ? 72  SER A H    1 
ATOM   1416 H  H    B SER A 1 72  ? -10.24800 -15.00300 17.16100  0.500 34.32516 ? 72  SER A H    1 
ATOM   1417 H  HA   A SER A 1 72  ? -9.63000  -17.82200 16.04800  0.500 45.06955 ? 72  SER A HA   1 
ATOM   1418 H  HA   B SER A 1 72  ? -9.04000  -17.11000 15.93700  0.500 46.01156 ? 72  SER A HA   1 
ATOM   1419 H  HB2  A SER A 1 72  ? -9.13000  -16.84500 14.01700  0.500 39.06855 ? 72  SER A HB2  1 
ATOM   1420 H  HB2  B SER A 1 72  ? -9.15300  -16.14600 13.98900  0.500 37.77454 ? 72  SER A HB2  1 
ATOM   1421 H  HB3  A SER A 1 72  ? -10.70800 -16.83300 14.20900  0.500 39.06855 ? 72  SER A HB3  1 
ATOM   1422 H  HB3  B SER A 1 72  ? -10.38000 -15.36500 14.62800  0.500 37.77454 ? 72  SER A HB3  1 
ATOM   1423 H  HG   A SER A 1 72  ? -10.56900 -14.74300 14.71400  0.500 38.59272 ? 72  SER A HG   1 
ATOM   1424 H  HG   B SER A 1 72  ? -9.02900  -13.73600 15.05600  0.500 42.96186 ? 72  SER A HG   1 
ATOM   1425 N  N    A ARG A 1 73  ? -7.29000  -16.79400 16.08300  0.500 26.56886 ? 73  ARG A N    1 
ATOM   1426 N  N    B ARG A 1 73  ? -6.73200  -16.48200 16.35200  0.500 27.19553 ? 73  ARG A N    1 
ATOM   1427 C  CA   A ARG A 1 73  ? -5.99200  -16.21700 16.37200  0.500 28.11040 ? 73  ARG A CA   1 
ATOM   1428 C  CA   B ARG A 1 73  ? -5.44600  -16.34900 17.03100  0.500 26.14279 ? 73  ARG A CA   1 
ATOM   1429 C  C    A ARG A 1 73  ? -5.46700  -15.49300 15.13700  0.500 29.69873 ? 73  ARG A C    1 
ATOM   1430 C  C    B ARG A 1 73  ? -4.49600  -15.37900 16.34900  0.500 23.76109 ? 73  ARG A C    1 
ATOM   1431 O  O    A ARG A 1 73  ? -5.97300  -15.65500 14.02100  0.500 35.51787 ? 73  ARG A O    1 
ATOM   1432 O  O    B ARG A 1 73  ? -3.58900  -14.85500 17.00400  0.500 29.76508 ? 73  ARG A O    1 
ATOM   1433 C  CB   A ARG A 1 73  ? -5.00900  -17.30200 16.81900  0.500 22.75625 ? 73  ARG A CB   1 
ATOM   1434 C  CB   B ARG A 1 73  ? -4.76500  -17.72300 17.13300  0.500 34.91485 ? 73  ARG A CB   1 
ATOM   1435 C  CG   A ARG A 1 73  ? -5.55800  -18.28900 17.85400  0.500 39.47182 ? 73  ARG A CG   1 
ATOM   1436 C  CG   B ARG A 1 73  ? -5.51800  -18.76100 17.97300  0.500 40.24436 ? 73  ARG A CG   1 
ATOM   1437 C  CD   A ARG A 1 73  ? -5.85500  -17.63300 19.20000  0.500 39.32072 ? 73  ARG A CD   1 
ATOM   1438 C  CD   B ARG A 1 73  ? -4.56400  -19.74600 18.67400  0.500 51.35316 ? 73  ARG A CD   1 
ATOM   1439 N  NE   A ARG A 1 73  ? -4.79000  -16.75100 19.66700  0.500 51.01941 ? 73  ARG A NE   1 
ATOM   1440 N  NE   B ARG A 1 73  ? -3.62200  -19.06100 19.55600  0.500 58.78622 ? 73  ARG A NE   1 
ATOM   1441 C  CZ   A ARG A 1 73  ? -3.64300  -17.16100 20.19600  0.500 53.12573 ? 73  ARG A CZ   1 
ATOM   1442 C  CZ   B ARG A 1 73  ? -2.41200  -19.50800 19.87200  0.500 55.36759 ? 73  ARG A CZ   1 
ATOM   1443 N  NH1  A ARG A 1 73  ? -3.37500  -18.44700 20.35700  0.500 58.20763 ? 73  ARG A NH1  1 
ATOM   1444 N  NH1  B ARG A 1 73  ? -1.98200  -20.69300 19.46900  0.500 47.58942 ? 73  ARG A NH1  1 
ATOM   1445 N  NH2  A ARG A 1 73  ? -2.74700  -16.25700 20.58200  0.500 50.79545 ? 73  ARG A NH2  1 
ATOM   1446 N  NH2  B ARG A 1 73  ? -1.61100  -18.74200 20.60900  0.500 54.15600 ? 73  ARG A NH2  1 
ATOM   1447 H  H    A ARG A 1 73  ? -7.26300  -17.49700 15.58800  0.500 31.88620 ? 73  ARG A H    1 
ATOM   1448 H  H    B ARG A 1 73  ? -6.75500  -17.14500 15.80500  0.500 32.63820 ? 73  ARG A H    1 
ATOM   1449 H  HA   A ARG A 1 73  ? -6.06700  -15.57000 17.09100  0.500 33.73605 ? 73  ARG A HA   1 
ATOM   1450 H  HA   B ARG A 1 73  ? -5.60800  -16.01800 17.92800  0.500 31.37492 ? 73  ARG A HA   1 
ATOM   1451 H  HB2  A ARG A 1 73  ? -4.74300  -17.81600 16.04000  0.500 27.31107 ? 73  ARG A HB2  1 
ATOM   1452 H  HB2  B ARG A 1 73  ? -4.67100  -18.08600 16.23800  0.500 41.90139 ? 73  ARG A HB2  1 
ATOM   1453 H  HB3  A ARG A 1 73  ? -4.23400  -16.87100 17.21200  0.500 27.31107 ? 73  ARG A HB3  1 
ATOM   1454 H  HB3  B ARG A 1 73  ? -3.89000  -17.60300 17.53500  0.500 41.90139 ? 73  ARG A HB3  1 
ATOM   1455 H  HG2  A ARG A 1 73  ? -6.38400  -18.67100 17.51800  0.500 47.36975 ? 73  ARG A HG2  1 
ATOM   1456 H  HG2  B ARG A 1 73  ? -6.03500  -18.30400 18.65500  0.500 48.29680 ? 73  ARG A HG2  1 
ATOM   1457 H  HG3  A ARG A 1 73  ? -4.90400  -18.99000 18.00000  0.500 47.36975 ? 73  ARG A HG3  1 
ATOM   1458 H  HG3  B ARG A 1 73  ? -6.10800  -19.27100 17.39600  0.500 48.29680 ? 73  ARG A HG3  1 
ATOM   1459 H  HD2  A ARG A 1 73  ? -6.66400  -17.10400 19.11800  0.500 47.18843 ? 73  ARG A HD2  1 
ATOM   1460 H  HD2  B ARG A 1 73  ? -5.08200  -20.36700 19.20900  0.500 61.62736 ? 73  ARG A HD2  1 
ATOM   1461 H  HD3  A ARG A 1 73  ? -5.97800  -18.32700 19.86600  0.500 47.18843 ? 73  ARG A HD3  1 
ATOM   1462 H  HD3  B ARG A 1 73  ? -4.05500  -20.22900 18.00400  0.500 61.62736 ? 73  ARG A HD3  1 
ATOM   1463 H  HE   A ARG A 1 73  ? -4.91400  -15.90300 19.59300  0.500 61.22686 ? 73  ARG A HE   1 
ATOM   1464 H  HE   B ARG A 1 73  ? -3.87000  -18.31100 19.89600  0.500 70.54703 ? 73  ARG A HE   1 
ATOM   1465 H  HH11 A ARG A 1 73  ? -3.95000  -19.03900 20.11600  0.500 69.85273 ? 73  ARG A HH11 1 
ATOM   1466 H  HH11 B ARG A 1 73  ? -2.49000  -21.19400 18.99000  0.500 57.11088 ? 73  ARG A HH11 1 
ATOM   1467 H  HH12 A ARG A 1 73  ? -2.62600  -18.69000 20.70200  0.500 69.85273 ? 73  ARG A HH12 1 
ATOM   1468 H  HH12 B ARG A 1 73  ? -1.19400  -20.96100 19.68600  0.500 57.11088 ? 73  ARG A HH12 1 
ATOM   1469 H  HH21 A ARG A 1 73  ? -2.91300  -15.41900 20.48600  0.500 60.95810 ? 73  ARG A HH21 1 
ATOM   1470 H  HH21 B ARG A 1 73  ? -1.88000  -17.96900 20.87400  0.500 64.99077 ? 73  ARG A HH21 1 
ATOM   1471 H  HH22 A ARG A 1 73  ? -2.00100  -16.51100 20.92600  0.500 60.95810 ? 73  ARG A HH22 1 
ATOM   1472 H  HH22 B ARG A 1 73  ? -0.82500  -19.02000 20.82100  0.500 64.99077 ? 73  ARG A HH22 1 
ATOM   1473 N  N    A ASN A 1 74  ? -4.46100  -14.65600 15.36700  0.510 25.79232 ? 74  ASN A N    1 
ATOM   1474 N  N    B ASN A 1 74  ? -4.67000  -15.12700 15.05500  0.490 20.71350 ? 74  ASN A N    1 
ATOM   1475 C  CA   A ASN A 1 74  ? -3.74400  -13.93300 14.32500  0.510 23.19784 ? 74  ASN A CA   1 
ATOM   1476 C  CA   B ASN A 1 74  ? -3.87700  -14.14600 14.33200  0.490 21.01631 ? 74  ASN A CA   1 
ATOM   1477 C  C    A ASN A 1 74  ? -2.26000  -14.25800 14.46800  0.510 21.89612 ? 74  ASN A C    1 
ATOM   1478 C  C    B ASN A 1 74  ? -2.37200  -14.32400 14.56900  0.490 22.48528 ? 74  ASN A C    1 
ATOM   1479 O  O    A ASN A 1 74  ? -1.44000  -13.37000 14.72000  0.510 23.40209 ? 74  ASN A O    1 
ATOM   1480 O  O    B ASN A 1 74  ? -1.65800  -13.40700 14.94800  0.490 24.48119 ? 74  ASN A O    1 
ATOM   1481 C  CB   A ASN A 1 74  ? -4.03800  -12.43300 14.46000  0.510 20.67272 ? 74  ASN A CB   1 
ATOM   1482 C  CB   B ASN A 1 74  ? -4.32400  -12.72400 14.66500  0.490 24.47709 ? 74  ASN A CB   1 
ATOM   1483 C  CG   A ASN A 1 74  ? -3.33000  -11.57100 13.41200  0.510 26.09428 ? 74  ASN A CG   1 
ATOM   1484 C  CG   B ASN A 1 74  ? -3.79600  -11.72700 13.67600  0.490 22.51848 ? 74  ASN A CG   1 
ATOM   1485 O  OD1  A ASN A 1 74  ? -2.78000  -12.06200 12.42900  0.510 23.30658 ? 74  ASN A OD1  1 
ATOM   1486 O  OD1  B ASN A 1 74  ? -3.19800  -12.10200 12.66800  0.490 23.43587 ? 74  ASN A OD1  1 
ATOM   1487 N  ND2  A ASN A 1 74  ? -3.35100  -10.26400 13.62900  0.510 24.04758 ? 74  ASN A ND2  1 
ATOM   1488 N  ND2  B ASN A 1 74  ? -4.01700  -10.45500 13.94000  0.490 28.54378 ? 74  ASN A ND2  1 
ATOM   1489 H  H    A ASN A 1 74  ? -4.16100  -14.48200 16.15400  0.510 30.95435 ? 74  ASN A H    1 
ATOM   1490 H  H    B ASN A 1 74  ? -5.25700  -15.52200 14.56600  0.490 24.85977 ? 74  ASN A H    1 
ATOM   1491 H  HA   A ASN A 1 74  ? -4.02400  -14.18800 13.43200  0.510 27.84098 ? 74  ASN A HA   1 
ATOM   1492 H  HA   B ASN A 1 74  ? -4.02900  -14.30000 13.38600  0.490 25.22314 ? 74  ASN A HA   1 
ATOM   1493 H  HB2  A ASN A 1 74  ? -4.99300  -12.29200 14.36400  0.510 24.81083 ? 74  ASN A HB2  1 
ATOM   1494 H  HB2  B ASN A 1 74  ? -5.29300  -12.68100 14.65100  0.490 29.37608 ? 74  ASN A HB2  1 
ATOM   1495 H  HB3  A ASN A 1 74  ? -3.74500  -12.13500 15.33600  0.510 24.81083 ? 74  ASN A HB3  1 
ATOM   1496 H  HB3  B ASN A 1 74  ? -3.99300  -12.48300 15.54400  0.490 29.37608 ? 74  ASN A HB3  1 
ATOM   1497 H  HD21 A ASN A 1 74  ? -2.97000  -9.72900  13.07400  0.510 28.86066 ? 74  ASN A HD21 1 
ATOM   1498 H  HD21 B ASN A 1 74  ? -3.73200  -9.84800  13.40200  0.490 34.25610 ? 74  ASN A HD21 1 
ATOM   1499 H  HD22 A ASN A 1 74  ? -3.74700  -9.95000  14.32500  0.510 28.86066 ? 74  ASN A HD22 1 
ATOM   1500 H  HD22 B ASN A 1 74  ? -4.44500  -10.23200 14.65200  0.490 34.25610 ? 74  ASN A HD22 1 
ATOM   1501 N  N    . LEU A 1 75  ? -1.90200  -15.53100 14.27900  1.000 23.07523 ? 75  LEU A N    1 
ATOM   1502 C  CA   . LEU A 1 75  ? -0.52600  -15.93300 14.59000  1.000 22.17462 ? 75  LEU A CA   1 
ATOM   1503 C  C    . LEU A 1 75  ? 0.50900   -15.29500 13.68300  1.000 24.17038 ? 75  LEU A C    1 
ATOM   1504 O  O    . LEU A 1 75  ? 1.68000   -15.20400 14.07400  1.000 27.01521 ? 75  LEU A O    1 
ATOM   1505 C  CB   . LEU A 1 75  ? -0.39700  -17.45200 14.55900  1.000 24.95512 ? 75  LEU A CB   1 
ATOM   1506 C  CG   . LEU A 1 75  ? -1.14700  -18.15400 15.69500  1.000 26.46925 ? 75  LEU A CG   1 
ATOM   1507 C  CD1  . LEU A 1 75  ? -1.07700  -19.66000 15.58600  1.000 34.18274 ? 75  LEU A CD1  1 
ATOM   1508 C  CD2  . LEU A 1 75  ? -0.64100  -17.68100 17.06600  1.000 43.67455 ? 75  LEU A CD2  1 
ATOM   1509 H  H    . LEU A 1 75  ? -2.41600  -16.15400 13.98500  1.000 27.69385 ? 75  LEU A H    1 
ATOM   1510 H  HA   . LEU A 1 75  ? -0.32700  -15.63800 15.49200  1.000 26.61311 ? 75  LEU A HA   1 
ATOM   1511 H  HB2  . LEU A 1 75  ? -0.75500  -17.77900 13.71900  1.000 29.94971 ? 75  LEU A HB2  1 
ATOM   1512 H  HB3  . LEU A 1 75  ? 0.54200   -17.68600 14.63300  1.000 29.94971 ? 75  LEU A HB3  1 
ATOM   1513 H  HG   . LEU A 1 75  ? -2.08300  -17.91100 15.61700  1.000 31.76667 ? 75  LEU A HG   1 
ATOM   1514 H  HD11 . LEU A 1 75  ? -1.49900  -20.05300 16.36600  1.000 41.02286 ? 75  LEU A HD11 1 
ATOM   1515 H  HD12 . LEU A 1 75  ? -1.54100  -19.94100 14.78200  1.000 41.02286 ? 75  LEU A HD12 1 
ATOM   1516 H  HD13 . LEU A 1 75  ? -0.14600  -19.93000 15.54300  1.000 41.02286 ? 75  LEU A HD13 1 
ATOM   1517 H  HD21 . LEU A 1 75  ? -0.88900  -18.33700 17.73700  1.000 52.41302 ? 75  LEU A HD21 1 
ATOM   1518 H  HD22 . LEU A 1 75  ? 0.32400   -17.59000 17.03200  1.000 52.41302 ? 75  LEU A HD22 1 
ATOM   1519 H  HD23 . LEU A 1 75  ? -1.04700  -16.82600 17.27500  1.000 52.41302 ? 75  LEU A HD23 1 
ATOM   1520 N  N    . CYS A 1 76  ? 0.14000   -14.87600 12.46700  1.000 21.15313 ? 76  CYS A N    1 
ATOM   1521 C  CA   . CYS A 1 76  ? 1.06200   -14.14000 11.61400  1.000 22.26979 ? 76  CYS A CA   1 
ATOM   1522 C  C    . CYS A 1 76  ? 1.01700   -12.63400 11.85000  1.000 22.54985 ? 76  CYS A C    1 
ATOM   1523 O  O    . CYS A 1 76  ? 1.80500   -11.89300 11.24100  1.000 24.88082 ? 76  CYS A O    1 
ATOM   1524 C  CB   . CYS A 1 76  ? 0.81700   -14.45400 10.13700  1.000 21.89049 ? 76  CYS A CB   1 
ATOM   1525 S  SG   . CYS A 1 76  ? 1.29500   -16.16000 9.74800   1.000 22.42854 ? 76  CYS A SG   1 
ATOM   1526 H  H    . CYS A 1 76  ? -0.63600  -15.00800 12.12100  1.000 25.38733 ? 76  CYS A H    1 
ATOM   1527 H  HA   . CYS A 1 76  ? 1.96200   -14.44200 11.81400  1.000 26.72732 ? 76  CYS A HA   1 
ATOM   1528 H  HB2  . CYS A 1 76  ? -0.12500  -14.34400 9.93500   1.000 26.27215 ? 76  CYS A HB2  1 
ATOM   1529 H  HB3  . CYS A 1 76  ? 1.34600   -13.85300 9.58800   1.000 26.27215 ? 76  CYS A HB3  1 
ATOM   1530 N  N    A ASN A 1 77  ? 0.10600   -12.17300 12.71200  0.440 23.77329 ? 77  ASN A N    1 
ATOM   1531 N  N    B ASN A 1 77  ? 0.10300   -12.16900 12.69900  0.560 23.81919 ? 77  ASN A N    1 
ATOM   1532 C  CA   A ASN A 1 77  ? 0.00500   -10.77000 13.11800  0.440 25.41604 ? 77  ASN A CA   1 
ATOM   1533 C  CA   B ASN A 1 77  ? 0.02700   -10.76800 13.10300  0.560 25.46000 ? 77  ASN A CA   1 
ATOM   1534 C  C    A ASN A 1 77  ? -0.14500  -9.84100  11.91500  0.440 27.65199 ? 77  ASN A C    1 
ATOM   1535 C  C    B ASN A 1 77  ? -0.14200  -9.83700  11.90600  0.560 27.70218 ? 77  ASN A C    1 
ATOM   1536 O  O    A ASN A 1 77  ? 0.59200   -8.86800  11.74500  0.440 28.50486 ? 77  ASN A O    1 
ATOM   1537 O  O    B ASN A 1 77  ? 0.58700   -8.85800  11.72900  0.560 28.38639 ? 77  ASN A O    1 
ATOM   1538 C  CB   A ASN A 1 77  ? 1.17500   -10.36400 14.02200  0.440 29.93870 ? 77  ASN A CB   1 
ATOM   1539 C  CB   B ASN A 1 77  ? 1.23300   -10.36900 13.95300  0.560 29.95852 ? 77  ASN A CB   1 
ATOM   1540 C  CG   A ASN A 1 77  ? 1.19200   -11.13600 15.33400  0.440 33.94741 ? 77  ASN A CG   1 
ATOM   1541 C  CG   B ASN A 1 77  ? 0.96600   -9.13500  14.76500  0.560 29.63659 ? 77  ASN A CG   1 
ATOM   1542 O  OD1  A ASN A 1 77  ? 2.14300   -11.86200 15.62500  0.440 45.27353 ? 77  ASN A OD1  1 
ATOM   1543 O  OD1  B ASN A 1 77  ? -0.10600  -8.99100  15.35700  0.560 40.97922 ? 77  ASN A OD1  1 
ATOM   1544 N  ND2  A ASN A 1 77  ? 0.13100   -10.98700 16.13100  0.440 42.21725 ? 77  ASN A ND2  1 
ATOM   1545 N  ND2  B ASN A 1 77  ? 1.93000   -8.22700  14.79000  0.560 37.55681 ? 77  ASN A ND2  1 
ATOM   1546 H  H    A ASN A 1 77  ? -0.48500  -12.67200 13.08700  0.440 28.53152 ? 77  ASN A H    1 
ATOM   1547 H  H    B ASN A 1 77  ? -0.50000  -12.66000 13.06600  0.560 28.58659 ? 77  ASN A H    1 
ATOM   1548 H  HA   A ASN A 1 77  ? -0.80500  -10.66700 13.64100  0.440 30.50282 ? 77  ASN A HA   1 
ATOM   1549 H  HA   B ASN A 1 77  ? -0.76800  -10.66300 13.64900  0.560 30.55556 ? 77  ASN A HA   1 
ATOM   1550 H  HB2  A ASN A 1 77  ? 2.00900   -10.54000 13.55900  0.440 35.93001 ? 77  ASN A HB2  1 
ATOM   1551 H  HB2  B ASN A 1 77  ? 1.44600   -11.09300 14.56300  0.560 35.95379 ? 77  ASN A HB2  1 
ATOM   1552 H  HB3  A ASN A 1 77  ? 1.10300   -9.42000  14.23000  0.440 35.93001 ? 77  ASN A HB3  1 
ATOM   1553 H  HB3  B ASN A 1 77  ? 1.98800   -10.19200 13.37100  0.560 35.95379 ? 77  ASN A HB3  1 
ATOM   1554 H  HD21 A ASN A 1 77  ? -0.51700  -10.47400 15.89300  0.440 50.66427 ? 77  ASN A HD21 1 
ATOM   1555 H  HD21 B ASN A 1 77  ? 2.65900   -8.36200  14.35600  0.560 45.07174 ? 77  ASN A HD21 1 
ATOM   1556 H  HD22 A ASN A 1 77  ? 0.09600   -11.40300 16.88300  0.440 50.66427 ? 77  ASN A HD22 1 
ATOM   1557 H  HD22 B ASN A 1 77  ? 1.82600   -7.50200  15.24100  0.560 45.07174 ? 77  ASN A HD22 1 
ATOM   1558 N  N    . ILE A 1 78  ? -1.13300  -10.14100 11.07400  1.000 24.40889 ? 78  ILE A N    1 
ATOM   1559 C  CA   . ILE A 1 78  ? -1.37400  -9.35000  9.87400   1.000 23.08012 ? 78  ILE A CA   1 
ATOM   1560 C  C    . ILE A 1 78  ? -2.86300  -9.34500  9.56400   1.000 20.55658 ? 78  ILE A C    1 
ATOM   1561 O  O    . ILE A 1 78  ? -3.55800  -10.31900 9.86900   1.000 21.84983 ? 78  ILE A O    1 
ATOM   1562 C  CB   . ILE A 1 78  ? -0.69000  -9.94700  8.63100   1.000 24.05357 ? 78  ILE A CB   1 
ATOM   1563 C  CG1  . ILE A 1 78  ? -0.97200  -11.44500 8.54400   1.000 23.92812 ? 78  ILE A CG1  1 
ATOM   1564 C  CG2  . ILE A 1 78  ? 0.79300   -9.60400  8.59300   1.000 36.66668 ? 78  ILE A CG2  1 
ATOM   1565 C  CD1  . ILE A 1 78  ? -0.43500  -12.09100 7.27900   1.000 48.46564 ? 78  ILE A CD1  1 
ATOM   1566 H  H    . ILE A 1 78  ? -1.67700  -10.79800 11.18100  1.000 29.29424 ? 78  ILE A H    1 
ATOM   1567 H  HA   . ILE A 1 78  ? -1.03800  -8.46000  10.06600  1.000 27.69971 ? 78  ILE A HA   1 
ATOM   1568 H  HB   . ILE A 1 78  ? -1.07200  -9.54200  7.83600   1.000 28.86785 ? 78  ILE A HB   1 
ATOM   1569 H  HG12 . ILE A 1 78  ? -0.55700  -11.88600 9.30200   1.000 28.71731 ? 78  ILE A HG12 1 
ATOM   1570 H  HG13 . ILE A 1 78  ? -1.93200  -11.58400 8.56400   1.000 28.71731 ? 78  ILE A HG13 1 
ATOM   1571 H  HG21 . ILE A 1 78  ? 1.18300   -9.97800  7.78700   1.000 44.00359 ? 78  ILE A HG21 1 
ATOM   1572 H  HG22 . ILE A 1 78  ? 0.89400   -8.63900  8.59200   1.000 44.00359 ? 78  ILE A HG22 1 
ATOM   1573 H  HG23 . ILE A 1 78  ? 1.22500   -9.98200  9.37500   1.000 44.00359 ? 78  ILE A HG23 1 
ATOM   1574 H  HD11 . ILE A 1 78  ? -0.65400  -13.03600 7.28900   1.000 58.16233 ? 78  ILE A HD11 1 
ATOM   1575 H  HD12 . ILE A 1 78  ? -0.84400  -11.66500 6.50900   1.000 58.16233 ? 78  ILE A HD12 1 
ATOM   1576 H  HD13 . ILE A 1 78  ? 0.52700   -11.97400 7.24900   1.000 58.16233 ? 78  ILE A HD13 1 
ATOM   1577 N  N    . PRO A 1 79  ? -3.37700  -8.29600  8.94000   1.000 22.54020 ? 79  PRO A N    1 
ATOM   1578 C  CA   . PRO A 1 79  ? -4.73300  -8.38200  8.40800   1.000 19.30654 ? 79  PRO A CA   1 
ATOM   1579 C  C    . PRO A 1 79  ? -4.73500  -9.35600  7.23900   1.000 18.41945 ? 79  PRO A C    1 
ATOM   1580 O  O    . PRO A 1 79  ? -3.80800  -9.39500  6.43100   1.000 20.14890 ? 79  PRO A O    1 
ATOM   1581 C  CB   . PRO A 1 79  ? -5.04900  -6.93800  7.99500   1.000 23.72730 ? 79  PRO A CB   1 
ATOM   1582 C  CG   . PRO A 1 79  ? -3.75900  -6.29300  7.78900   1.000 33.08981 ? 79  PRO A CG   1 
ATOM   1583 C  CD   . PRO A 1 79  ? -2.73700  -7.00700  8.63100   1.000 25.81985 ? 79  PRO A CD   1 
ATOM   1584 H  HA   . PRO A 1 79  ? -5.39000  -8.64700  9.07000   1.000 23.17142 ? 79  PRO A HA   1 
ATOM   1585 H  HB2  . PRO A 1 79  ? -5.56800  -6.93900  7.17600   1.000 28.47633 ? 79  PRO A HB2  1 
ATOM   1586 H  HB3  . PRO A 1 79  ? -5.54500  -6.49700  8.70200   1.000 28.47633 ? 79  PRO A HB3  1 
ATOM   1587 H  HG2  . PRO A 1 79  ? -3.52000  -6.35200  6.85100   1.000 39.71133 ? 79  PRO A HG2  1 
ATOM   1588 H  HG3  . PRO A 1 79  ? -3.82300  -5.36300  8.05700   1.000 39.71133 ? 79  PRO A HG3  1 
ATOM   1589 H  HD2  . PRO A 1 79  ? -1.91600  -7.14200  8.13300   1.000 30.98739 ? 79  PRO A HD2  1 
ATOM   1590 H  HD3  . PRO A 1 79  ? -2.55500  -6.51000  9.44400   1.000 30.98739 ? 79  PRO A HD3  1 
ATOM   1591 N  N    . CYS A 1 80  ? -5.81100  -10.11000 7.13600   1.000 18.10284 ? 80  CYS A N    1 
ATOM   1592 C  CA   . CYS A 1 80  ? -5.89700  -11.07200 6.04500   1.000 16.60807 ? 80  CYS A CA   1 
ATOM   1593 C  C    . CYS A 1 80  ? -5.84200  -10.39300 4.67700   1.000 17.75579 ? 80  CYS A C    1 
ATOM   1594 O  O    . CYS A 1 80  ? -5.35300  -10.99600 3.71200   1.000 18.66675 ? 80  CYS A O    1 
ATOM   1595 C  CB   . CYS A 1 80  ? -7.17600  -11.86900 6.16000   1.000 17.84323 ? 80  CYS A CB   1 
ATOM   1596 S  SG   . CYS A 1 80  ? -7.32300  -12.88200 7.66300   1.000 17.54125 ? 80  CYS A SG   1 
ATOM   1597 H  H    . CYS A 1 80  ? -6.48900  -10.08900 7.66500   1.000 21.72698 ? 80  CYS A H    1 
ATOM   1598 H  HA   . CYS A 1 80  ? -5.14200  -11.67800 6.11400   1.000 19.93325 ? 80  CYS A HA   1 
ATOM   1599 H  HB2  . CYS A 1 80  ? -7.92300  -11.25000 6.15300   1.000 21.41544 ? 80  CYS A HB2  1 
ATOM   1600 H  HB3  . CYS A 1 80  ? -7.23300  -12.46700 5.39900   1.000 21.41544 ? 80  CYS A HB3  1 
ATOM   1601 N  N    . SER A 1 81  ? -6.33800  -9.15000  4.56200   1.000 19.23949 ? 81  SER A N    1 
ATOM   1602 C  CA   . SER A 1 81  ? -6.25500  -8.43000  3.28900   1.000 20.04063 ? 81  SER A CA   1 
ATOM   1603 C  C    . SER A 1 81  ? -4.82900  -8.25900  2.79100   1.000 19.57114 ? 81  SER A C    1 
ATOM   1604 O  O    . SER A 1 81  ? -4.60800  -8.16500  1.57200   1.000 23.47767 ? 81  SER A O    1 
ATOM   1605 C  CB   . SER A 1 81  ? -6.93300  -7.06100  3.43000   1.000 22.50696 ? 81  SER A CB   1 
ATOM   1606 O  OG   . SER A 1 81  ? -6.25600  -6.26000  4.38400   1.000 26.33737 ? 81  SER A OG   1 
ATOM   1607 H  H    . SER A 1 81  ? -6.72000  -8.71200  5.19500   1.000 23.09096 ? 81  SER A H    1 
ATOM   1608 H  HA   . SER A 1 81  ? -6.72600  -8.95000  2.61900   1.000 24.05233 ? 81  SER A HA   1 
ATOM   1609 H  HB2  . SER A 1 81  ? -6.91800  -6.61100  2.57100   1.000 27.01192 ? 81  SER A HB2  1 
ATOM   1610 H  HB3  . SER A 1 81  ? -7.85000  -7.19100  3.72100   1.000 27.01192 ? 81  SER A HB3  1 
ATOM   1611 H  HG   . SER A 1 81  ? -6.63200  -6.32400  5.13200   1.000 31.60841 ? 81  SER A HG   1 
ATOM   1612 N  N    . ALA A 1 82  ? -3.84900  -8.23400  3.68700   1.000 18.75779 ? 82  ALA A N    1 
ATOM   1613 C  CA   . ALA A 1 82  ? -2.45400  -8.13100  3.27200   1.000 21.72616 ? 82  ALA A CA   1 
ATOM   1614 C  C    . ALA A 1 82  ? -2.03300  -9.31700  2.43400   1.000 23.99729 ? 82  ALA A C    1 
ATOM   1615 O  O    . ALA A 1 82  ? -1.07300  -9.22900  1.65500   1.000 26.58951 ? 82  ALA A O    1 
ATOM   1616 C  CB   . ALA A 1 82  ? -1.54800  -8.05800  4.49900   1.000 27.58240 ? 82  ALA A CB   1 
ATOM   1617 H  H    . ALA A 1 82  ? -3.96200  -8.27600  4.53800   1.000 22.51292 ? 82  ALA A H    1 
ATOM   1618 H  HA   . ALA A 1 82  ? -2.35400  -7.32000  2.74900   1.000 26.07496 ? 82  ALA A HA   1 
ATOM   1619 H  HB1  . ALA A 1 82  ? -0.62600  -7.99300  4.20700   1.000 33.10245 ? 82  ALA A HB1  1 
ATOM   1620 H  HB2  . ALA A 1 82  ? -1.78600  -7.27500  5.02000   1.000 33.10245 ? 82  ALA A HB2  1 
ATOM   1621 H  HB3  . ALA A 1 82  ? -1.67200  -8.85900  5.03100   1.000 33.10245 ? 82  ALA A HB3  1 
ATOM   1622 N  N    . LEU A 1 83  ? -2.69100  -10.44400 2.60300   1.000 20.71598 ? 83  LEU A N    1 
ATOM   1623 C  CA   . LEU A 1 83  ? -2.35200  -11.65200 1.87600   1.000 20.99100 ? 83  LEU A CA   1 
ATOM   1624 C  C    . LEU A 1 83  ? -2.89000  -11.66900 0.45500   1.000 22.46420 ? 83  LEU A C    1 
ATOM   1625 O  O    . LEU A 1 83  ? -2.66700  -12.65000 -0.26800  1.000 24.66992 ? 83  LEU A O    1 
ATOM   1626 C  CB   . LEU A 1 83  ? -2.89100  -12.86300 2.62800   1.000 20.51881 ? 83  LEU A CB   1 
ATOM   1627 C  CG   . LEU A 1 83  ? -2.40400  -12.98700 4.06600   1.000 23.26133 ? 83  LEU A CG   1 
ATOM   1628 C  CD1  . LEU A 1 83  ? -3.14400  -14.11800 4.74900   1.000 24.09314 ? 83  LEU A CD1  1 
ATOM   1629 C  CD2  . LEU A 1 83  ? -0.89800  -13.24400 4.08600   1.000 30.04870 ? 83  LEU A CD2  1 
ATOM   1630 H  H    . LEU A 1 83  ? -3.35300  -10.53900 3.14400   1.000 24.86274 ? 83  LEU A H    1 
ATOM   1631 H  HA   . LEU A 1 83  ? -1.38600  -11.71900 1.82400   1.000 25.19277 ? 83  LEU A HA   1 
ATOM   1632 H  HB2  . LEU A 1 83  ? -3.85900  -12.80600 2.65000   1.000 24.62614 ? 83  LEU A HB2  1 
ATOM   1633 H  HB3  . LEU A 1 83  ? -2.61700  -13.66500 2.15600   1.000 24.62614 ? 83  LEU A HB3  1 
ATOM   1634 H  HG   . LEU A 1 83  ? -2.57700  -12.16400 4.54900   1.000 27.91717 ? 83  LEU A HG   1 
ATOM   1635 H  HD11 . LEU A 1 83  ? -2.78700  -14.23500 5.64300   1.000 28.91533 ? 83  LEU A HD11 1 
ATOM   1636 H  HD12 . LEU A 1 83  ? -4.08700  -13.89600 4.79600   1.000 28.91533 ? 83  LEU A HD12 1 
ATOM   1637 H  HD13 . LEU A 1 83  ? -3.02100  -14.93200 4.23500   1.000 28.91533 ? 83  LEU A HD13 1 
ATOM   1638 H  HD21 . LEU A 1 83  ? -0.68000  -13.78500 4.86100   1.000 36.06201 ? 83  LEU A HD21 1 
ATOM   1639 H  HD22 . LEU A 1 83  ? -0.64600  -13.71200 3.27400   1.000 36.06201 ? 83  LEU A HD22 1 
ATOM   1640 H  HD23 . LEU A 1 83  ? -0.43300  -12.39400 4.13500   1.000 36.06201 ? 83  LEU A HD23 1 
ATOM   1641 N  N    . LEU A 1 84  ? -3.61700  -10.63600 0.02600   1.000 19.70893 ? 84  LEU A N    1 
ATOM   1642 C  CA   . LEU A 1 84  ? -4.17400  -10.59300 -1.31800  1.000 20.61011 ? 84  LEU A CA   1 
ATOM   1643 C  C    . LEU A 1 84  ? -3.36200  -9.71100  -2.25300  1.000 22.24093 ? 84  LEU A C    1 
ATOM   1644 O  O    . LEU A 1 84  ? -3.71900  -9.58100  -3.43700  1.000 26.16203 ? 84  LEU A O    1 
ATOM   1645 C  CB   . LEU A 1 84  ? -5.63100  -10.12700 -1.28000  1.000 20.34402 ? 84  LEU A CB   1 
ATOM   1646 C  CG   . LEU A 1 84  ? -6.51600  -10.86700 -0.27300  1.000 22.16871 ? 84  LEU A CG   1 
ATOM   1647 C  CD1  . LEU A 1 84  ? -7.90700  -10.26400 -0.15500  1.000 29.77758 ? 84  LEU A CD1  1 
ATOM   1648 C  CD2  . LEU A 1 84  ? -6.62400  -12.30900 -0.65200  1.000 22.70940 ? 84  LEU A CD2  1 
ATOM   1649 H  H    . LEU A 1 84  ? -3.80000  -9.94400  0.50200   1.000 23.65429 ? 84  LEU A H    1 
ATOM   1650 H  HA   . LEU A 1 84  ? -4.17700  -11.49000 -1.68500  1.000 24.73570 ? 84  LEU A HA   1 
ATOM   1651 H  HB2  . LEU A 1 84  ? -5.64700  -9.18500  -1.04600  1.000 24.41640 ? 84  LEU A HB2  1 
ATOM   1652 H  HB3  . LEU A 1 84  ? -6.01800  -10.25600 -2.16000  1.000 24.41640 ? 84  LEU A HB3  1 
ATOM   1653 H  HG   . LEU A 1 84  ? -6.09700  -10.78400 0.59800   1.000 26.60602 ? 84  LEU A HG   1 
ATOM   1654 H  HD11 . LEU A 1 84  ? -8.41600  -10.76900 0.49800   1.000 35.73666 ? 84  LEU A HD11 1 
ATOM   1655 H  HD12 . LEU A 1 84  ? -7.82700  -9.34000  0.13100   1.000 35.73666 ? 84  LEU A HD12 1 
ATOM   1656 H  HD13 . LEU A 1 84  ? -8.34400  -10.30600 -1.01900  1.000 35.73666 ? 84  LEU A HD13 1 
ATOM   1657 H  HD21 . LEU A 1 84  ? -7.20300  -12.76000 -0.01700  1.000 27.25485 ? 84  LEU A HD21 1 
ATOM   1658 H  HD22 . LEU A 1 84  ? -6.99800  -12.37400 -1.54500  1.000 27.25485 ? 84  LEU A HD22 1 
ATOM   1659 H  HD23 . LEU A 1 84  ? -5.74000  -12.70800 -0.63400  1.000 27.25485 ? 84  LEU A HD23 1 
ATOM   1660 N  N    . SER A 1 85  ? -2.26800  -9.15500  -1.75500  1.000 23.61853 ? 85  SER A N    1 
ATOM   1661 C  CA   . SER A 1 85  ? -1.44300  -8.23100  -2.50500  1.000 21.62182 ? 85  SER A CA   1 
ATOM   1662 C  C    . SER A 1 85  ? -0.75600  -8.89900  -3.68400  1.000 26.92712 ? 85  SER A C    1 
ATOM   1663 O  O    . SER A 1 85  ? -0.47600  -10.09700 -3.67900  1.000 25.76417 ? 85  SER A O    1 
ATOM   1664 C  CB   . SER A 1 85  ? -0.38500  -7.68300  -1.54700  1.000 26.19526 ? 85  SER A CB   1 
ATOM   1665 O  OG   . SER A 1 85  ? 0.49800   -6.80300  -2.22100  1.000 31.80253 ? 85  SER A OG   1 
ATOM   1666 H  H    . SER A 1 85  ? -1.97500  -9.30200  -0.96000  1.000 28.34580 ? 85  SER A H    1 
ATOM   1667 H  HA   . SER A 1 85  ? -1.98800  -7.51700  -2.87000  1.000 25.94975 ? 85  SER A HA   1 
ATOM   1668 H  HB2  . SER A 1 85  ? -0.82700  -7.20000  -0.83100  1.000 31.43788 ? 85  SER A HB2  1 
ATOM   1669 H  HB3  . SER A 1 85  ? 0.12400   -8.42400  -1.18200  1.000 31.43788 ? 85  SER A HB3  1 
ATOM   1670 H  HG   . SER A 1 85  ? 1.18700   -6.67700  -1.75800  1.000 38.16660 ? 85  SER A HG   1 
ATOM   1671 N  N    . SER A 1 86  ? -0.43400  -8.09300  -4.69800  1.000 26.03788 ? 86  SER A N    1 
ATOM   1672 C  CA   . SER A 1 86  ? 0.39700   -8.58100  -5.78800  1.000 24.72357 ? 86  SER A CA   1 
ATOM   1673 C  C    . SER A 1 86  ? 1.81700   -8.89700  -5.33200  1.000 24.27404 ? 86  SER A C    1 
ATOM   1674 O  O    . SER A 1 86  ? 2.50400   -9.68300  -5.99400  1.000 30.20953 ? 86  SER A O    1 
ATOM   1675 C  CB   . SER A 1 86  ? 0.43600   -7.55300  -6.92100  1.000 32.29845 ? 86  SER A CB   1 
ATOM   1676 O  OG   . SER A 1 86  ? 0.70700   -6.25800  -6.41200  1.000 50.95373 ? 86  SER A OG   1 
ATOM   1677 H  H    . SER A 1 86  ? -0.68200  -7.27300  -4.77400  1.000 31.24903 ? 86  SER A H    1 
ATOM   1678 H  HA   . SER A 1 86  ? 0.00500   -9.39700  -6.13700  1.000 29.67186 ? 86  SER A HA   1 
ATOM   1679 H  HB2  . SER A 1 86  ? 1.13400   -7.79900  -7.54800  1.000 38.76171 ? 86  SER A HB2  1 
ATOM   1680 H  HB3  . SER A 1 86  ? -0.42400  -7.54300  -7.36900  1.000 38.76171 ? 86  SER A HB3  1 
ATOM   1681 H  HG   . SER A 1 86  ? 0.68800   -5.69500  -7.03500  1.000 61.14805 ? 86  SER A HG   1 
ATOM   1682 N  N    . ASP A 1 87  ? 2.27100   -8.29000  -4.23800  1.000 24.69189 ? 87  ASP A N    1 
ATOM   1683 C  CA   . ASP A 1 87  ? 3.54400   -8.58900  -3.59400  1.000 23.84722 ? 87  ASP A CA   1 
ATOM   1684 C  C    . ASP A 1 87  ? 3.31200   -9.75600  -2.64200  1.000 28.54298 ? 87  ASP A C    1 
ATOM   1685 O  O    . ASP A 1 87  ? 2.51900   -9.64100  -1.70100  1.000 25.52175 ? 87  ASP A O    1 
ATOM   1686 C  CB   . ASP A 1 87  ? 3.94600   -7.34300  -2.80700  1.000 27.10306 ? 87  ASP A CB   1 
ATOM   1687 C  CG   . ASP A 1 87  ? 5.25700   -7.49600  -2.03300  1.000 34.24998 ? 87  ASP A CG   1 
ATOM   1688 O  OD1  . ASP A 1 87  ? 5.80300   -8.60000  -1.88900  1.000 30.80330 ? 87  ASP A OD1  1 
ATOM   1689 O  OD2  . ASP A 1 87  ? 5.77500   -6.45500  -1.56900  1.000 57.53070 ? 87  ASP A OD2  1 
ATOM   1690 H  H    . ASP A 1 87  ? 1.83600   -7.67000  -3.83000  1.000 29.63384 ? 87  ASP A H    1 
ATOM   1691 H  HA   . ASP A 1 87  ? 4.23800   -8.83200  -4.22700  1.000 28.62024 ? 87  ASP A HA   1 
ATOM   1692 H  HB2  . ASP A 1 87  ? 4.05300   -6.60400  -3.42500  1.000 32.52724 ? 87  ASP A HB2  1 
ATOM   1693 H  HB3  . ASP A 1 87  ? 3.24700   -7.14100  -2.16500  1.000 32.52724 ? 87  ASP A HB3  1 
ATOM   1694 N  N    . ILE A 1 88  ? 3.97700   -10.88600 -2.90500  1.000 23.06619 ? 88  ILE A N    1 
ATOM   1695 C  CA   . ILE A 1 88  ? 3.72200   -12.10300 -2.12600  1.000 20.69292 ? 88  ILE A CA   1 
ATOM   1696 C  C    . ILE A 1 88  ? 4.46000   -12.15900 -0.80300  1.000 23.61405 ? 88  ILE A C    1 
ATOM   1697 O  O    . ILE A 1 88  ? 4.34200   -13.16100 -0.08100  1.000 21.16806 ? 88  ILE A O    1 
ATOM   1698 C  CB   . ILE A 1 88  ? 4.01600   -13.38100 -2.93300  1.000 22.33033 ? 88  ILE A CB   1 
ATOM   1699 C  CG1  . ILE A 1 88  ? 5.51500   -13.50200 -3.26900  1.000 26.60178 ? 88  ILE A CG1  1 
ATOM   1700 C  CG2  . ILE A 1 88  ? 3.14800   -13.39700 -4.17300  1.000 25.68980 ? 88  ILE A CG2  1 
ATOM   1701 C  CD1  . ILE A 1 88  ? 5.89900   -14.89500 -3.80400  1.000 27.40756 ? 88  ILE A CD1  1 
ATOM   1702 H  H    . ILE A 1 88  ? 4.57200   -10.97300 -3.51900  1.000 27.68299 ? 88  ILE A H    1 
ATOM   1703 H  HA   . ILE A 1 88  ? 2.77400   -12.09300 -1.91900  1.000 24.83507 ? 88  ILE A HA   1 
ATOM   1704 H  HB   . ILE A 1 88  ? 3.79700   -14.15600 -2.39300  1.000 26.79996 ? 88  ILE A HB   1 
ATOM   1705 H  HG12 . ILE A 1 88  ? 5.74000   -12.84700 -3.94800  1.000 31.92571 ? 88  ILE A HG12 1 
ATOM   1706 H  HG13 . ILE A 1 88  ? 6.03200   -13.33800 -2.46500  1.000 31.92571 ? 88  ILE A HG13 1 
ATOM   1707 H  HG21 . ILE A 1 88  ? 3.29700   -14.22800 -4.65100  1.000 30.83132 ? 88  ILE A HG21 1 
ATOM   1708 H  HG22 . ILE A 1 88  ? 2.21800   -13.33000 -3.90800  1.000 30.83132 ? 88  ILE A HG22 1 
ATOM   1709 H  HG23 . ILE A 1 88  ? 3.38800   -12.64400 -4.73500  1.000 30.83132 ? 88  ILE A HG23 1 
ATOM   1710 H  HD11 . ILE A 1 88  ? 6.80000   -14.85800 -4.16000  1.000 32.89264 ? 88  ILE A HD11 1 
ATOM   1711 H  HD12 . ILE A 1 88  ? 5.85500   -15.53600 -3.07800  1.000 32.89264 ? 88  ILE A HD12 1 
ATOM   1712 H  HD13 . ILE A 1 88  ? 5.27600   -15.14600 -4.50500  1.000 32.89264 ? 88  ILE A HD13 1 
ATOM   1713 N  N    . THR A 1 89  ? 5.22500   -11.12700 -0.45000  1.000 22.37655 ? 89  THR A N    1 
ATOM   1714 C  CA   . THR A 1 89  ? 6.03900   -11.16300 0.75800   1.000 21.69169 ? 89  THR A CA   1 
ATOM   1715 C  C    . THR A 1 89  ? 5.24900   -11.60700 1.99000   1.000 21.43946 ? 89  THR A C    1 
ATOM   1716 O  O    . THR A 1 89  ? 5.67000   -12.51100 2.70300   1.000 22.36381 ? 89  THR A O    1 
ATOM   1717 C  CB   . THR A 1 89  ? 6.67000   -9.78200  0.97400   1.000 25.80319 ? 89  THR A CB   1 
ATOM   1718 O  OG1  . THR A 1 89  ? 7.48700   -9.47500  -0.16400  1.000 30.86164 ? 89  THR A OG1  1 
ATOM   1719 C  CG2  . THR A 1 89  ? 7.50900   -9.78900  2.22600   1.000 31.72795 ? 89  THR A CG2  1 
ATOM   1720 H  H    . THR A 1 89  ? 5.28900   -10.39400 -0.89400  1.000 26.85543 ? 89  THR A H    1 
ATOM   1721 H  HA   . THR A 1 89  ? 6.74400   -11.81800 0.63600   1.000 26.03360 ? 89  THR A HA   1 
ATOM   1722 H  HB   . THR A 1 89  ? 5.98600   -9.10200  1.07700   1.000 30.96739 ? 89  THR A HB   1 
ATOM   1723 H  HG1  . THR A 1 89  ? 8.27900   -9.33700  0.07900   1.000 37.03754 ? 89  THR A HG1  1 
ATOM   1724 H  HG21 . THR A 1 89  ? 8.13600   -9.04800  2.20900   1.000 38.07711 ? 89  THR A HG21 1 
ATOM   1725 H  HG22 . THR A 1 89  ? 6.94100   -9.70400  3.00700   1.000 38.07711 ? 89  THR A HG22 1 
ATOM   1726 H  HG23 . THR A 1 89  ? 8.00600   -10.62000 2.28700   1.000 38.07711 ? 89  THR A HG23 1 
ATOM   1727 N  N    . ALA A 1 90  ? 4.10300   -10.97600 2.26900   1.000 21.53856 ? 90  ALA A N    1 
ATOM   1728 C  CA   . ALA A 1 90  ? 3.37600   -11.30000 3.49300   1.000 21.01662 ? 90  ALA A CA   1 
ATOM   1729 C  C    . ALA A 1 90  ? 2.87600   -12.74200 3.47200   1.000 20.62340 ? 90  ALA A C    1 
ATOM   1730 O  O    . ALA A 1 90  ? 2.92200   -13.43800 4.49000   1.000 21.21175 ? 90  ALA A O    1 
ATOM   1731 C  CB   . ALA A 1 90  ? 2.21700   -10.31400 3.68000   1.000 23.69545 ? 90  ALA A CB   1 
ATOM   1732 H  H    . ALA A 1 90  ? 3.73600   -10.37400 1.77700   1.000 25.84984 ? 90  ALA A H    1 
ATOM   1733 H  HA   . ALA A 1 90  ? 3.97100   -11.20900 4.25400   1.000 25.22351 ? 90  ALA A HA   1 
ATOM   1734 H  HB1  . ALA A 1 90  ? 1.67200   -10.60600 4.42700   1.000 28.43811 ? 90  ALA A HB1  1 
ATOM   1735 H  HB2  . ALA A 1 90  ? 2.57800   -9.43200  3.85800   1.000 28.43811 ? 90  ALA A HB2  1 
ATOM   1736 H  HB3  . ALA A 1 90  ? 1.68400   -10.29600 2.86900   1.000 28.43811 ? 90  ALA A HB3  1 
ATOM   1737 N  N    . SER A 1 91  ? 2.41500   -13.21700 2.31500   1.000 18.67666 ? 91  SER A N    1 
ATOM   1738 C  CA   . SER A 1 91  ? 1.99400   -14.60600 2.21800   1.000 17.53822 ? 91  SER A CA   1 
ATOM   1739 C  C    . SER A 1 91  ? 3.14800   -15.55500 2.46600   1.000 18.48744 ? 91  SER A C    1 
ATOM   1740 O  O    . SER A 1 91  ? 2.97200   -16.56800 3.14500   1.000 19.40605 ? 91  SER A O    1 
ATOM   1741 C  CB   . SER A 1 91  ? 1.39000   -14.87600 0.84800   1.000 19.56037 ? 91  SER A CB   1 
ATOM   1742 O  OG   . SER A 1 91  ? 0.04400   -14.42400 0.79200   1.000 20.60488 ? 91  SER A OG   1 
ATOM   1743 H  H    . SER A 1 91  ? 2.33900   -12.76400 1.58800   1.000 22.41556 ? 91  SER A H    1 
ATOM   1744 H  HA   . SER A 1 91  ? 1.31500   -14.76600 2.89200   1.000 21.04944 ? 91  SER A HA   1 
ATOM   1745 H  HB2  . SER A 1 91  ? 1.90900   -14.40700 0.17600   1.000 23.47601 ? 91  SER A HB2  1 
ATOM   1746 H  HB3  . SER A 1 91  ? 1.41100   -15.83100 0.67600   1.000 23.47601 ? 91  SER A HB3  1 
ATOM   1747 H  HG   . SER A 1 91  ? -0.27000  -14.54900 0.02300   1.000 24.72943 ? 91  SER A HG   1 
ATOM   1748 N  N    . VAL A 1 92  ? 4.32100   -15.27000 1.89500   1.000 18.62141 ? 92  VAL A N    1 
ATOM   1749 C  CA   . VAL A 1 92  ? 5.48300   -16.12900 2.08700   1.000 18.71208 ? 92  VAL A CA   1 
ATOM   1750 C  C    . VAL A 1 92  ? 5.93100   -16.13000 3.53800   1.000 20.15433 ? 92  VAL A C    1 
ATOM   1751 O  O    . VAL A 1 92  ? 6.21100   -17.19200 4.12100   1.000 20.99476 ? 92  VAL A O    1 
ATOM   1752 C  CB   . VAL A 1 92  ? 6.61700   -15.71300 1.12200   1.000 23.02303 ? 92  VAL A CB   1 
ATOM   1753 C  CG1  . VAL A 1 92  ? 7.94800   -16.26000 1.61100   1.000 26.88013 ? 92  VAL A CG1  1 
ATOM   1754 C  CG2  . VAL A 1 92  ? 6.29300   -16.14900 -0.27200  1.000 25.75274 ? 92  VAL A CG2  1 
ATOM   1755 H  H    . VAL A 1 92  ? 4.46700   -14.58600 1.39400   1.000 22.34926 ? 92  VAL A H    1 
ATOM   1756 H  HA   . VAL A 1 92  ? 5.22800   -17.03900 1.87100   1.000 22.45806 ? 92  VAL A HA   1 
ATOM   1757 H  HB   . VAL A 1 92  ? 6.70100   -14.74600 1.10200   1.000 27.63121 ? 92  VAL A HB   1 
ATOM   1758 H  HG11 . VAL A 1 92  ? 8.58500   -16.24100 0.88000   1.000 32.25972 ? 92  VAL A HG11 1 
ATOM   1759 H  HG12 . VAL A 1 92  ? 8.26600   -15.70800 2.34300   1.000 32.25972 ? 92  VAL A HG12 1 
ATOM   1760 H  HG13 . VAL A 1 92  ? 7.82100   -17.17200 1.91600   1.000 32.25972 ? 92  VAL A HG13 1 
ATOM   1761 H  HG21 . VAL A 1 92  ? 6.82500   -15.63100 -0.89600  1.000 30.90685 ? 92  VAL A HG21 1 
ATOM   1762 H  HG22 . VAL A 1 92  ? 6.50000   -17.09200 -0.36400  1.000 30.90685 ? 92  VAL A HG22 1 
ATOM   1763 H  HG23 . VAL A 1 92  ? 5.34900   -15.99900 -0.43800  1.000 30.90685 ? 92  VAL A HG23 1 
ATOM   1764 N  N    . ASN A 1 93  ? 5.98600   -14.96000 4.16400   1.000 20.61980 ? 93  ASN A N    1 
ATOM   1765 C  CA   . ASN A 1 93  ? 6.45900   -14.90400 5.54200   1.000 23.34617 ? 93  ASN A CA   1 
ATOM   1766 C  C    . ASN A 1 93  ? 5.51900   -15.66200 6.46300   1.000 21.40375 ? 93  ASN A C    1 
ATOM   1767 O  O    . ASN A 1 93  ? 5.94800   -16.36600 7.37900   1.000 23.59903 ? 93  ASN A O    1 
ATOM   1768 C  CB   . ASN A 1 93  ? 6.59700   -13.44600 5.98900   1.000 25.76719 ? 93  ASN A CB   1 
ATOM   1769 C  CG   . ASN A 1 93  ? 7.78000   -12.75900 5.33500   1.000 36.55779 ? 93  ASN A CG   1 
ATOM   1770 O  OD1  . ASN A 1 93  ? 8.60200   -13.41300 4.69600   1.000 34.60507 ? 93  ASN A OD1  1 
ATOM   1771 N  ND2  . ASN A 1 93  ? 7.87100   -11.44100 5.49000   1.000 48.98374 ? 93  ASN A ND2  1 
ATOM   1772 H  H    . ASN A 1 93  ? 5.76100   -14.20300 3.82400   1.000 24.74733 ? 93  ASN A H    1 
ATOM   1773 H  HA   . ASN A 1 93  ? 7.33500   -15.31500 5.59600   1.000 28.01898 ? 93  ASN A HA   1 
ATOM   1774 H  HB2  . ASN A 1 93  ? 5.79300   -12.96100 5.74700   1.000 30.92420 ? 93  ASN A HB2  1 
ATOM   1775 H  HB3  . ASN A 1 93  ? 6.72400   -13.41800 6.95000   1.000 30.92420 ? 93  ASN A HB3  1 
ATOM   1776 H  HD21 . ASN A 1 93  ? 7.27500   -11.01900 5.94500   1.000 58.78405 ? 93  ASN A HD21 1 
ATOM   1777 H  HD22 . ASN A 1 93  ? 8.52600   -11.01000 5.13600   1.000 58.78405 ? 93  ASN A HD22 1 
ATOM   1778 N  N    . CYS A 1 94  ? 4.21200   -15.56900 6.21100   1.000 19.23248 ? 94  CYS A N    1 
ATOM   1779 C  CA   . CYS A 1 94  ? 3.25300   -16.30000 7.02900   1.000 19.63015 ? 94  CYS A CA   1 
ATOM   1780 C  C    . CYS A 1 94  ? 3.32900   -17.80400 6.75500   1.000 19.97821 ? 94  CYS A C    1 
ATOM   1781 O  O    . CYS A 1 94  ? 3.32800   -18.61500 7.69300   1.000 19.79308 ? 94  CYS A O    1 
ATOM   1782 C  CB   . CYS A 1 94  ? 1.85500   -15.73500 6.78700   1.000 20.31435 ? 94  CYS A CB   1 
ATOM   1783 S  SG   . CYS A 1 94  ? 0.57200   -16.42500 7.86800   1.000 21.05333 ? 94  CYS A SG   1 
ATOM   1784 H  H    . CYS A 1 94  ? 3.86400   -15.09600 5.58300   1.000 23.08255 ? 94  CYS A H    1 
ATOM   1785 H  HA   . CYS A 1 94  ? 3.45600   -16.18000 7.97000   1.000 23.55975 ? 94  CYS A HA   1 
ATOM   1786 H  HB2  . CYS A 1 94  ? 1.87900   -14.77700 6.93300   1.000 24.38079 ? 94  CYS A HB2  1 
ATOM   1787 H  HB3  . CYS A 1 94  ? 1.60000   -15.92400 5.87000   1.000 24.38079 ? 94  CYS A HB3  1 
ATOM   1788 N  N    . ALA A 1 95  ? 3.46500   -18.19700 5.49200   1.000 17.55877 ? 95  ALA A N    1 
ATOM   1789 C  CA   . ALA A 1 95  ? 3.63700   -19.60900 5.15600   1.000 17.65603 ? 95  ALA A CA   1 
ATOM   1790 C  C    . ALA A 1 95  ? 4.85300   -20.22300 5.83100   1.000 18.67092 ? 95  ALA A C    1 
ATOM   1791 O  O    . ALA A 1 95  ? 4.81500   -21.39900 6.19300   1.000 19.25667 ? 95  ALA A O    1 
ATOM   1792 C  CB   . ALA A 1 95  ? 3.77000   -19.77100 3.65200   1.000 19.53512 ? 95  ALA A CB   1 
ATOM   1793 H  H    . ALA A 1 95  ? 3.46200   -17.67000 4.81300   1.000 21.07409 ? 95  ALA A H    1 
ATOM   1794 H  HA   . ALA A 1 95  ? 2.84800   -20.08100 5.46600   1.000 21.19081 ? 95  ALA A HA   1 
ATOM   1795 H  HB1  . ALA A 1 95  ? 3.85000   -20.71500 3.44200   1.000 23.44571 ? 95  ALA A HB1  1 
ATOM   1796 H  HB2  . ALA A 1 95  ? 2.98200   -19.40300 3.22400   1.000 23.44571 ? 95  ALA A HB2  1 
ATOM   1797 H  HB3  . ALA A 1 95  ? 4.56100   -19.29700 3.35200   1.000 23.44571 ? 95  ALA A HB3  1 
ATOM   1798 N  N    . LYS A 1 96  ? 5.94800   -19.47200 5.96900   1.000 18.91616 ? 96  LYS A N    1 
ATOM   1799 C  CA   . LYS A 1 96  ? 7.12500   -19.99400 6.66200   1.000 18.91528 ? 96  LYS A CA   1 
ATOM   1800 C  C    . LYS A 1 96  ? 6.79100   -20.35000 8.10600   1.000 21.87727 ? 96  LYS A C    1 
ATOM   1801 O  O    . LYS A 1 96  ? 7.27700   -21.35600 8.63900   1.000 22.02950 ? 96  LYS A O    1 
ATOM   1802 C  CB   . LYS A 1 96  ? 8.25000   -18.95300 6.60900   1.000 20.53729 ? 96  LYS A CB   1 
ATOM   1803 C  CG   . LYS A 1 96  ? 8.88900   -18.81600 5.26200   1.000 22.22259 ? 96  LYS A CG   1 
ATOM   1804 C  CD   . LYS A 1 96  ? 10.03300  -17.79900 5.29800   1.000 24.56594 ? 96  LYS A CD   1 
ATOM   1805 C  CE   . LYS A 1 96  ? 10.72100  -17.70200 3.93800   1.000 30.09574 ? 96  LYS A CE   1 
ATOM   1806 N  NZ   . LYS A 1 96  ? 11.68900  -16.55100 3.86800   1.000 34.27063 ? 96  LYS A NZ   1 
ATOM   1807 H  H    . LYS A 1 96  ? 6.03400   -18.66900 5.67500   1.000 22.70296 ? 96  LYS A H    1 
ATOM   1808 H  HA   . LYS A 1 96  ? 7.43200   -20.80000 6.21700   1.000 22.70190 ? 96  LYS A HA   1 
ATOM   1809 H  HB2  . LYS A 1 96  ? 7.88500   -18.08800 6.85200   1.000 24.64832 ? 96  LYS A HB2  1 
ATOM   1810 H  HB3  . LYS A 1 96  ? 8.94100   -19.21100 7.23900   1.000 24.64832 ? 96  LYS A HB3  1 
ATOM   1811 H  HG2  . LYS A 1 96  ? 9.24900   -19.67300 4.98600   1.000 26.67067 ? 96  LYS A HG2  1 
ATOM   1812 H  HG3  . LYS A 1 96  ? 8.22800   -18.51100 4.62000   1.000 26.67067 ? 96  LYS A HG3  1 
ATOM   1813 H  HD2  . LYS A 1 96  ? 9.68200   -16.92500 5.52800   1.000 29.48270 ? 96  LYS A HD2  1 
ATOM   1814 H  HD3  . LYS A 1 96  ? 10.69100  -18.07600 5.95600   1.000 29.48270 ? 96  LYS A HD3  1 
ATOM   1815 H  HE2  . LYS A 1 96  ? 11.21300  -18.52100 3.77200   1.000 36.11846 ? 96  LYS A HE2  1 
ATOM   1816 H  HE3  . LYS A 1 96  ? 10.04900  -17.57300 3.25100   1.000 36.11846 ? 96  LYS A HE3  1 
ATOM   1817 H  HZ1  . LYS A 1 96  ? 12.05000  -16.50600 3.05600   1.000 41.12832 ? 96  LYS A HZ1  1 
ATOM   1818 H  HZ2  . LYS A 1 96  ? 11.26700  -15.78700 4.03900   1.000 41.12832 ? 96  LYS A HZ2  1 
ATOM   1819 H  HZ3  . LYS A 1 96  ? 12.33800  -16.66200 4.46700   1.000 41.12832 ? 96  LYS A HZ3  1 
ATOM   1820 N  N    A LYS A 1 97  ? 5.96300   -19.53700 8.75800   0.530 19.52612 ? 97  LYS A N    1 
ATOM   1821 N  N    B LYS A 1 97  ? 5.95000   -19.54600 8.75800   0.470 19.56729 ? 97  LYS A N    1 
ATOM   1822 C  CA   A LYS A 1 97  ? 5.52800   -19.85800 10.11100  0.530 19.86860 ? 97  LYS A CA   1 
ATOM   1823 C  CA   B LYS A 1 97  ? 5.53900   -19.86600 10.12200  0.470 19.96661 ? 97  LYS A CA   1 
ATOM   1824 C  C    A LYS A 1 97  ? 4.66200   -21.11200 10.12300  0.530 20.93638 ? 97  LYS A C    1 
ATOM   1825 C  C    B LYS A 1 97  ? 4.63700   -21.09900 10.14800  0.470 21.04772 ? 97  LYS A C    1 
ATOM   1826 O  O    A LYS A 1 97  ? 4.82500   -21.98600 10.98600  0.530 23.99945 ? 97  LYS A O    1 
ATOM   1827 O  O    B LYS A 1 97  ? 4.74700   -21.94500 11.04700  0.470 23.78152 ? 97  LYS A O    1 
ATOM   1828 C  CB   A LYS A 1 97  ? 4.77400   -18.67100 10.71600  0.530 23.60411 ? 97  LYS A CB   1 
ATOM   1829 C  CB   B LYS A 1 97  ? 4.84000   -18.66200 10.76700  0.470 23.81589 ? 97  LYS A CB   1 
ATOM   1830 C  CG   A LYS A 1 97  ? 5.68100   -17.47000 10.95200  0.530 23.50038 ? 97  LYS A CG   1 
ATOM   1831 C  CG   B LYS A 1 97  ? 4.52300   -18.83800 12.25500  0.470 25.76237 ? 97  LYS A CG   1 
ATOM   1832 C  CD   A LYS A 1 97  ? 4.94000   -16.26500 11.51200  0.530 37.21530 ? 97  LYS A CD   1 
ATOM   1833 C  CD   B LYS A 1 97  ? 3.92800   -17.56100 12.89500  0.470 35.15035 ? 97  LYS A CD   1 
ATOM   1834 C  CE   A LYS A 1 97  ? 5.72500   -14.97100 11.27200  0.530 39.80932 ? 97  LYS A CE   1 
ATOM   1835 C  CE   B LYS A 1 97  ? 4.95900   -16.46800 13.23400  0.470 44.97573 ? 97  LYS A CE   1 
ATOM   1836 N  NZ   A LYS A 1 97  ? 4.85000   -13.76300 11.34200  0.530 43.54532 ? 97  LYS A NZ   1 
ATOM   1837 N  NZ   B LYS A 1 97  ? 6.39200   -16.85500 13.07700  0.470 48.91340 ? 97  LYS A NZ   1 
ATOM   1838 H  H    A LYS A 1 97  ? 5.64400   -18.80300 8.44300   0.530 23.43491 ? 97  LYS A H    1 
ATOM   1839 H  H    B LYS A 1 97  ? 5.61000   -18.82300 8.44000   0.470 23.48432 ? 97  LYS A H    1 
ATOM   1840 H  HA   A LYS A 1 97  ? 6.30800   -20.02700 10.66200  0.530 23.84589 ? 97  LYS A HA   1 
ATOM   1841 H  HA   B LYS A 1 97  ? 6.32900   -20.06000 10.64900  0.470 23.96350 ? 97  LYS A HA   1 
ATOM   1842 H  HB2  A LYS A 1 97  ? 4.06700   -18.40100 10.11000  0.530 28.32850 ? 97  LYS A HB2  1 
ATOM   1843 H  HB2  B LYS A 1 97  ? 5.41600   -17.88600 10.68000  0.470 28.58264 ? 97  LYS A HB2  1 
ATOM   1844 H  HB3  A LYS A 1 97  ? 4.39700   -18.93700 11.56900  0.530 28.32850 ? 97  LYS A HB3  1 
ATOM   1845 H  HB3  B LYS A 1 97  ? 4.00200   -18.50600 10.30500  0.470 28.58264 ? 97  LYS A HB3  1 
ATOM   1846 H  HG2  A LYS A 1 97  ? 6.37300   -17.71600 11.58600  0.530 28.20402 ? 97  LYS A HG2  1 
ATOM   1847 H  HG2  B LYS A 1 97  ? 3.87700   -19.55400 12.35900  0.470 30.91841 ? 97  LYS A HG2  1 
ATOM   1848 H  HG3  A LYS A 1 97  ? 6.08300   -17.20800 10.10900  0.530 28.20402 ? 97  LYS A HG3  1 
ATOM   1849 H  HG3  B LYS A 1 97  ? 5.34100   -19.05700 12.72900  0.470 30.91841 ? 97  LYS A HG3  1 
ATOM   1850 H  HD2  A LYS A 1 97  ? 4.07800   -16.18600 11.07500  0.530 44.66193 ? 97  LYS A HD2  1 
ATOM   1851 H  HD2  B LYS A 1 97  ? 3.28800   -17.17500 12.27600  0.470 42.18398 ? 97  LYS A HD2  1 
ATOM   1852 H  HD3  A LYS A 1 97  ? 4.81900   -16.37700 12.46800  0.530 44.66193 ? 97  LYS A HD3  1 
ATOM   1853 H  HD3  B LYS A 1 97  ? 3.48300   -17.80700 13.72100  0.470 42.18398 ? 97  LYS A HD3  1 
ATOM   1854 H  HE2  A LYS A 1 97  ? 6.41300   -14.88500 11.95000  0.530 47.77475 ? 97  LYS A HE2  1 
ATOM   1855 H  HE2  B LYS A 1 97  ? 4.80100   -15.70900 12.65000  0.470 53.97445 ? 97  LYS A HE2  1 
ATOM   1856 H  HE3  A LYS A 1 97  ? 6.12900   -15.00100 10.39100  0.530 47.77475 ? 97  LYS A HE3  1 
ATOM   1857 H  HE3  B LYS A 1 97  ? 4.83200   -16.20700 14.15900  0.470 53.97445 ? 97  LYS A HE3  1 
ATOM   1858 H  HZ1  A LYS A 1 97  ? 5.32700   -13.03200 11.16900  0.530 52.25795 ? 97  LYS A HZ1  1 
ATOM   1859 H  HZ1  B LYS A 1 97  ? 6.57300   -17.00900 12.21900  0.470 58.69964 ? 97  LYS A HZ1  1 
ATOM   1860 H  HZ2  A LYS A 1 97  ? 4.19400   -13.82800 10.74500  0.530 52.25795 ? 97  LYS A HZ2  1 
ATOM   1861 H  HZ2  B LYS A 1 97  ? 6.91800   -16.20000 13.37000  0.470 58.69964 ? 97  LYS A HZ2  1 
ATOM   1862 H  HZ3  A LYS A 1 97  ? 4.49500   -13.69100 12.15500  0.530 52.25795 ? 97  LYS A HZ3  1 
ATOM   1863 H  HZ3  B LYS A 1 97  ? 6.56100   -17.59300 13.54500  0.470 58.69964 ? 97  LYS A HZ3  1 
ATOM   1864 N  N    . ILE A 1 98  ? 3.72500   -21.21500 9.18200   1.000 18.39546 ? 98  ILE A N    1 
ATOM   1865 C  CA   . ILE A 1 98  ? 2.82900   -22.36300 9.14300   1.000 19.56476 ? 98  ILE A CA   1 
ATOM   1866 C  C    . ILE A 1 98  ? 3.60600   -23.66200 8.96200   1.000 17.68536 ? 98  ILE A C    1 
ATOM   1867 O  O    . ILE A 1 98  ? 3.35400   -24.65000 9.66200   1.000 20.15606 ? 98  ILE A O    1 
ATOM   1868 C  CB   . ILE A 1 98  ? 1.78200   -22.17000 8.03000   1.000 18.60566 ? 98  ILE A CB   1 
ATOM   1869 C  CG1  . ILE A 1 98  ? 0.91900   -20.93500 8.32300   1.000 20.50566 ? 98  ILE A CG1  1 
ATOM   1870 C  CG2  . ILE A 1 98  ? 0.92100   -23.41200 7.85400   1.000 19.46111 ? 98  ILE A CG2  1 
ATOM   1871 C  CD1  . ILE A 1 98  ? 0.02000   -20.50200 7.14200   1.000 20.50753 ? 98  ILE A CD1  1 
ATOM   1872 H  H    . ILE A 1 98  ? 3.59100   -20.63500 8.56100   1.000 22.07813 ? 98  ILE A H    1 
ATOM   1873 H  HA   . ILE A 1 98  ? 2.37100   -22.42100 9.99600   1.000 23.48128 ? 98  ILE A HA   1 
ATOM   1874 H  HB   . ILE A 1 98  ? 2.25400   -22.02600 7.19500   1.000 22.33036 ? 98  ILE A HB   1 
ATOM   1875 H  HG12 . ILE A 1 98  ? 0.34200   -21.13100 9.07700   1.000 24.61036 ? 98  ILE A HG12 1 
ATOM   1876 H  HG13 . ILE A 1 98  ? 1.50400   -20.19100 8.53700   1.000 24.61036 ? 98  ILE A HG13 1 
ATOM   1877 H  HG21 . ILE A 1 98  ? 0.27400   -23.25100 7.15000   1.000 23.35691 ? 98  ILE A HG21 1 
ATOM   1878 H  HG22 . ILE A 1 98  ? 1.49100   -24.16000 7.61400   1.000 23.35691 ? 98  ILE A HG22 1 
ATOM   1879 H  HG23 . ILE A 1 98  ? 0.46200   -23.59900 8.68800   1.000 23.35691 ? 98  ILE A HG23 1 
ATOM   1880 H  HD11 . ILE A 1 98  ? 0.57700   -20.33400 6.36600   1.000 24.61260 ? 98  ILE A HD11 1 
ATOM   1881 H  HD12 . ILE A 1 98  ? -0.61100  -21.21200 6.94900   1.000 24.61260 ? 98  ILE A HD12 1 
ATOM   1882 H  HD13 . ILE A 1 98  ? -0.45600  -19.69300 7.38700   1.000 24.61260 ? 98  ILE A HD13 1 
ATOM   1883 N  N    . VAL A 1 99  ? 4.50600   -23.71000 7.98000   1.000 17.76749 ? 99  VAL A N    1 
ATOM   1884 C  CA   . VAL A 1 99  ? 5.19800   -24.94000 7.64100   1.000 18.60666 ? 99  VAL A CA   1 
ATOM   1885 C  C    . VAL A 1 99  ? 6.14200   -25.35000 8.73800   1.000 22.48436 ? 99  VAL A C    1 
ATOM   1886 O  O    . VAL A 1 99  ? 6.52600   -26.51900 8.79600   1.000 23.12236 ? 99  VAL A O    1 
ATOM   1887 C  CB   . VAL A 1 99  ? 5.89600   -24.77600 6.27800   1.000 18.90969 ? 99  VAL A CB   1 
ATOM   1888 C  CG1  . VAL A 1 99  ? 7.18600   -23.96600 6.38900   1.000 20.83253 ? 99  VAL A CG1  1 
ATOM   1889 C  CG2  . VAL A 1 99  ? 6.12100   -26.12500 5.62000   1.000 21.87032 ? 99  VAL A CG2  1 
ATOM   1890 H  H    . VAL A 1 99  ? 4.73100   -23.03700 7.49400   1.000 21.32456 ? 99  VAL A H    1 
ATOM   1891 H  HA   . VAL A 1 99  ? 4.56200   -25.66500 7.54700   1.000 22.33156 ? 99  VAL A HA   1 
ATOM   1892 H  HB   . VAL A 1 99  ? 5.30900   -24.26600 5.69700   1.000 22.69520 ? 99  VAL A HB   1 
ATOM   1893 H  HG11 . VAL A 1 99  ? 7.50300   -23.75300 5.49800   1.000 25.00261 ? 99  VAL A HG11 1 
ATOM   1894 H  HG12 . VAL A 1 99  ? 7.00500   -23.15000 6.88000   1.000 25.00261 ? 99  VAL A HG12 1 
ATOM   1895 H  HG13 . VAL A 1 99  ? 7.85100   -24.49400 6.85900   1.000 25.00261 ? 99  VAL A HG13 1 
ATOM   1896 H  HG21 . VAL A 1 99  ? 6.40500   -25.98500 4.70300   1.000 26.24795 ? 99  VAL A HG21 1 
ATOM   1897 H  HG22 . VAL A 1 99  ? 6.80800   -26.60400 6.10900   1.000 26.24795 ? 99  VAL A HG22 1 
ATOM   1898 H  HG23 . VAL A 1 99  ? 5.29200   -26.62700 5.63600   1.000 26.24795 ? 99  VAL A HG23 1 
ATOM   1899 N  N    . SER A 1 100 ? 6.48200   -24.44300 9.63900   1.000 22.19435 ? 100 SER A N    1 
ATOM   1900 C  CA   . SER A 1 100 ? 7.37000   -24.73500 10.75800  1.000 25.54005 ? 100 SER A CA   1 
ATOM   1901 C  C    . SER A 1 100 ? 6.64600   -25.17700 12.01800  1.000 25.76212 ? 100 SER A C    1 
ATOM   1902 O  O    . SER A 1 100 ? 7.31400   -25.42900 13.03200  1.000 32.65282 ? 100 SER A O    1 
ATOM   1903 C  CB   . SER A 1 100 ? 8.18200   -23.48000 11.09300  1.000 25.95785 ? 100 SER A CB   1 
ATOM   1904 O  OG   . SER A 1 100 ? 9.01200   -23.05700 10.02800  1.000 29.10638 ? 100 SER A OG   1 
ATOM   1905 H  H    . SER A 1 100 ? 6.20600   -23.62900 9.62600   1.000 26.63679 ? 100 SER A H    1 
ATOM   1906 H  HA   . SER A 1 100 ? 7.96500   -25.45300 10.49100  1.000 30.65163 ? 100 SER A HA   1 
ATOM   1907 H  HB2  . SER A 1 100 ? 7.56400   -22.76200 11.30400  1.000 31.15299 ? 100 SER A HB2  1 
ATOM   1908 H  HB3  . SER A 1 100 ? 8.74100   -23.67200 11.86200  1.000 31.15299 ? 100 SER A HB3  1 
ATOM   1909 H  HG   . SER A 1 100 ? 8.54500   -22.87800 9.35400   1.000 34.93122 ? 100 SER A HG   1 
ATOM   1910 N  N    A ASP A 1 101 ? 5.32800   -25.29000 12.00400  0.660 24.92996 ? 101 ASP A N    1 
ATOM   1911 N  N    B ASP A 1 101 ? 5.31200   -25.28500 11.98700  0.340 25.21455 ? 101 ASP A N    1 
ATOM   1912 C  CA   A ASP A 1 101 ? 4.57500   -25.52000 13.22600  0.660 31.40794 ? 101 ASP A CA   1 
ATOM   1913 C  CA   B ASP A 1 101 ? 4.52000   -25.53100 13.18900  0.340 31.22988 ? 101 ASP A CA   1 
ATOM   1914 C  C    A ASP A 1 101 ? 4.40100   -26.99400 13.56500  0.660 34.93925 ? 101 ASP A C    1 
ATOM   1915 C  C    B ASP A 1 101 ? 4.60400   -26.97300 13.67700  0.340 33.37841 ? 101 ASP A C    1 
ATOM   1916 O  O    A ASP A 1 101 ? 3.61400   -27.31500 14.46300  0.660 36.24313 ? 101 ASP A O    1 
ATOM   1917 O  O    B ASP A 1 101 ? 4.27600   -27.23700 14.83800  0.340 27.94897 ? 101 ASP A O    1 
ATOM   1918 C  CB   A ASP A 1 101 ? 3.22400   -24.82800 13.13400  0.660 31.21866 ? 101 ASP A CB   1 
ATOM   1919 C  CB   B ASP A 1 101 ? 3.05200   -25.17400 12.92400  0.340 31.58863 ? 101 ASP A CB   1 
ATOM   1920 C  CG   A ASP A 1 101 ? 2.21100   -25.62000 12.34300  0.660 29.95757 ? 101 ASP A CG   1 
ATOM   1921 C  CG   B ASP A 1 101 ? 2.43000   -24.34900 14.04500  0.340 37.20776 ? 101 ASP A CG   1 
ATOM   1922 O  OD1  A ASP A 1 101 ? 2.53200   -26.72100 11.82200  0.660 27.73949 ? 101 ASP A OD1  1 
ATOM   1923 O  OD1  B ASP A 1 101 ? 3.17400   -23.64400 14.75900  0.340 43.53443 ? 101 ASP A OD1  1 
ATOM   1924 O  OD2  A ASP A 1 101 ? 1.08100   -25.11700 12.20800  0.660 36.61734 ? 101 ASP A OD2  1 
ATOM   1925 O  OD2  B ASP A 1 101 ? 1.19100   -24.38500 14.19300  0.340 40.59898 ? 101 ASP A OD2  1 
ATOM   1926 H  H    A ASP A 1 101 ? 4.84500   -25.23700 11.29500  0.660 29.91952 ? 101 ASP A H    1 
ATOM   1927 H  H    B ASP A 1 101 ? 4.84000   -25.21900 11.27100  0.340 30.26103 ? 101 ASP A H    1 
ATOM   1928 H  HA   A ASP A 1 101 ? 5.06200   -25.12400 13.96500  0.660 37.69310 ? 101 ASP A HA   1 
ATOM   1929 H  HA   B ASP A 1 101 ? 4.85600   -24.96100 13.89800  0.340 37.47942 ? 101 ASP A HA   1 
ATOM   1930 H  HB2  A ASP A 1 101 ? 2.87200   -24.70300 14.03000  0.660 37.46596 ? 101 ASP A HB2  1 
ATOM   1931 H  HB2  B ASP A 1 101 ? 2.99600   -24.65800 12.10500  0.340 37.90992 ? 101 ASP A HB2  1 
ATOM   1932 H  HB3  A ASP A 1 101 ? 3.33800   -23.96900 12.69900  0.660 37.46596 ? 101 ASP A HB3  1 
ATOM   1933 H  HB3  B ASP A 1 101 ? 2.54000   -25.99300 12.83600  0.340 37.90992 ? 101 ASP A HB3  1 
ATOM   1934 N  N    . GLY A 1 102 ? 5.07500   -27.89200 12.84400  1.000 28.74286 ? 102 GLY A N    1 
ATOM   1935 C  CA   . GLY A 1 102 ? 5.11600   -29.30500 13.18500  1.000 29.06830 ? 102 GLY A CA   1 
ATOM   1936 C  C    . GLY A 1 102 ? 4.53000   -30.25700 12.16300  1.000 29.61729 ? 102 GLY A C    1 
ATOM   1937 O  O    . GLY A 1 102 ? 4.95100   -31.41400 12.09800  1.000 28.81341 ? 102 GLY A O    1 
ATOM   1938 H  H    . GLY A 1 102 ? 5.52400   -27.69200 12.13800  1.000 34.49500 ? 102 GLY A H    1 
ATOM   1939 H  HA2  . GLY A 1 102 ? 6.04200   -29.56000 13.32100  1.000 34.88553 ? 102 GLY A HA2  1 
ATOM   1940 H  HA3  . GLY A 1 102 ? 4.62900   -29.43400 14.01400  1.000 34.88553 ? 102 GLY A HA3  1 
ATOM   1941 N  N    A ASN A 1 103 ? 3.58600   -29.78800 11.35300  0.680 25.48915 ? 103 ASN A N    1 
ATOM   1942 N  N    B ASN A 1 103 ? 3.54800   -29.81000 11.37900  0.320 25.71085 ? 103 ASN A N    1 
ATOM   1943 C  CA   A ASN A 1 103 ? 2.89400   -30.62400 10.38300  0.680 26.29273 ? 103 ASN A CA   1 
ATOM   1944 C  CA   B ASN A 1 103 ? 2.89500   -30.66100 10.39100  0.320 26.45057 ? 103 ASN A CA   1 
ATOM   1945 C  C    A ASN A 1 103 ? 3.38300   -30.40000 8.96700   0.680 19.15980 ? 103 ASN A C    1 
ATOM   1946 C  C    B ASN A 1 103 ? 3.41800   -30.44800 8.97600   0.320 19.51131 ? 103 ASN A C    1 
ATOM   1947 O  O    A ASN A 1 103 ? 2.88400   -31.04000 8.03700   0.680 21.76123 ? 103 ASN A O    1 
ATOM   1948 O  O    B ASN A 1 103 ? 2.94900   -31.11500 8.04800   0.320 21.56354 ? 103 ASN A O    1 
ATOM   1949 C  CB   A ASN A 1 103 ? 1.40400   -30.39000 10.52100  0.680 30.77636 ? 103 ASN A CB   1 
ATOM   1950 C  CB   B ASN A 1 103 ? 1.38200   -30.45200 10.43000  0.320 30.80906 ? 103 ASN A CB   1 
ATOM   1951 C  CG   A ASN A 1 103 ? 0.92800   -30.75400 11.89700  0.680 34.03479 ? 103 ASN A CG   1 
ATOM   1952 C  CG   B ASN A 1 103 ? 0.63600   -31.71500 10.81900  0.320 35.47808 ? 103 ASN A CG   1 
ATOM   1953 O  OD1  A ASN A 1 103 ? 1.12900   -31.88500 12.33700  0.680 40.53654 ? 103 ASN A OD1  1 
ATOM   1954 O  OD1  B ASN A 1 103 ? -0.00800  -31.77300 11.86600  0.320 41.90382 ? 103 ASN A OD1  1 
ATOM   1955 N  ND2  A ASN A 1 103 ? 0.37000   -29.79100 12.61300  0.680 47.58252 ? 103 ASN A ND2  1 
ATOM   1956 N  ND2  B ASN A 1 103 ? 0.72300   -32.73500 9.97600   0.320 34.17473 ? 103 ASN A ND2  1 
ATOM   1957 H  H    A ASN A 1 103 ? 3.32400   -28.96900 11.34700  0.680 30.59055 ? 103 ASN A H    1 
ATOM   1958 H  H    B ASN A 1 103 ? 3.24100   -29.00800 11.40300  0.320 30.85658 ? 103 ASN A H    1 
ATOM   1959 H  HA   A ASN A 1 103 ? 3.05000   -31.56400 10.56600  0.680 31.55484 ? 103 ASN A HA   1 
ATOM   1960 H  HA   B ASN A 1 103 ? 3.06600   -31.58700 10.62400  0.320 31.74426 ? 103 ASN A HA   1 
ATOM   1961 H  HB2  A ASN A 1 103 ? 1.20900   -29.45300 10.36500  0.680 36.93520 ? 103 ASN A HB2  1 
ATOM   1962 H  HB2  B ASN A 1 103 ? 1.17200   -29.76500 11.08200  0.320 36.97444 ? 103 ASN A HB2  1 
ATOM   1963 H  HB3  A ASN A 1 103 ? 0.93000   -30.93900 9.87600   0.680 36.93520 ? 103 ASN A HB3  1 
ATOM   1964 H  HB3  B ASN A 1 103 ? 1.07600   -30.17900 9.55100   0.320 36.97444 ? 103 ASN A HB3  1 
ATOM   1965 H  HD21 A ASN A 1 103 ? 0.29300   -29.00000 12.28400  0.680 57.10259 ? 103 ASN A HD21 1 
ATOM   1966 H  HD21 B ASN A 1 103 ? 0.31800   -33.47400 10.15100  0.320 41.01325 ? 103 ASN A HD21 1 
ATOM   1967 H  HD22 A ASN A 1 103 ? 0.08300   -29.95600 13.40700  0.680 57.10259 ? 103 ASN A HD22 1 
ATOM   1968 H  HD22 B ASN A 1 103 ? 1.18500   -32.65900 9.25400   0.320 41.01325 ? 103 ASN A HD22 1 
ATOM   1969 N  N    . GLY A 1 104 ? 4.40800   -29.58300 8.79700   1.000 19.76791 ? 104 GLY A N    1 
ATOM   1970 C  CA   . GLY A 1 104 ? 4.96300   -29.36700 7.48800   1.000 19.83112 ? 104 GLY A CA   1 
ATOM   1971 C  C    . GLY A 1 104 ? 3.91300   -28.88200 6.51500   1.000 19.00677 ? 104 GLY A C    1 
ATOM   1972 O  O    . GLY A 1 104 ? 3.00500   -28.12400 6.86300   1.000 20.67400 ? 104 GLY A O    1 
ATOM   1973 H  H    . GLY A 1 104 ? 4.79300   -29.14500 9.42800   1.000 23.72506 ? 104 GLY A H    1 
ATOM   1974 H  HA2  . GLY A 1 104 ? 5.66800   -28.70200 7.54000   1.000 23.80092 ? 104 GLY A HA2  1 
ATOM   1975 H  HA3  . GLY A 1 104 ? 5.33600   -30.19700 7.15200   1.000 23.80092 ? 104 GLY A HA3  1 
ATOM   1976 N  N    . MET A 1 105 ? 4.02600   -29.32100 5.28400   1.000 16.14698 ? 105 MET A N    1 
ATOM   1977 C  CA   . MET A 1 105 ? 3.09100   -28.85100 4.24800   1.000 15.39910 ? 105 MET A CA   1 
ATOM   1978 C  C    . MET A 1 105 ? 1.75000   -29.55500 4.30000   1.000 16.92736 ? 105 MET A C    1 
ATOM   1979 O  O    . MET A 1 105 ? 0.84900   -29.19600 3.52400   1.000 16.34986 ? 105 MET A O    1 
ATOM   1980 C  CB   . MET A 1 105 ? 3.70300   -28.94400 2.85200   1.000 15.78020 ? 105 MET A CB   1 
ATOM   1981 C  CG   . MET A 1 105 ? 4.89300   -28.02300 2.61700   1.000 18.51137 ? 105 MET A CG   1 
ATOM   1982 S  SD   . MET A 1 105 ? 5.21600   -27.57600 0.88900   1.000 19.20877 ? 105 MET A SD   1 
ATOM   1983 C  CE   . MET A 1 105 ? 3.71000   -26.79900 0.32200   1.000 20.84133 ? 105 MET A CE   1 
ATOM   1984 H  H    . MET A 1 105 ? 4.62000   -29.88000 5.01200   1.000 19.37995 ? 105 MET A H    1 
ATOM   1985 H  HA   . MET A 1 105 ? 2.93900   -27.90500 4.39800   1.000 18.48249 ? 105 MET A HA   1 
ATOM   1986 H  HB2  . MET A 1 105 ? 4.00600   -29.85400 2.70800   1.000 18.93981 ? 105 MET A HB2  1 
ATOM   1987 H  HB3  . MET A 1 105 ? 3.02200   -28.71300 2.20100   1.000 18.93981 ? 105 MET A HB3  1 
ATOM   1988 H  HG2  . MET A 1 105 ? 4.73900   -27.19800 3.10300   1.000 22.21722 ? 105 MET A HG2  1 
ATOM   1989 H  HG3  . MET A 1 105 ? 5.68900   -28.46300 2.95400   1.000 22.21722 ? 105 MET A HG3  1 
ATOM   1990 H  HE1  . MET A 1 105 ? 3.83500   -26.49500 -0.59100  1.000 25.01316 ? 105 MET A HE1  1 
ATOM   1991 H  HE2  . MET A 1 105 ? 2.98700   -27.44500 0.36000   1.000 25.01316 ? 105 MET A HE2  1 
ATOM   1992 H  HE3  . MET A 1 105 ? 3.50800   -26.04400 0.89700   1.000 25.01316 ? 105 MET A HE3  1 
ATOM   1993 N  N    . ASN A 1 106 ? 1.57800   -30.54200 5.18300   1.000 17.29932 ? 106 ASN A N    1 
ATOM   1994 C  CA   . ASN A 1 106 ? 0.27700   -31.18400 5.36000   1.000 16.40344 ? 106 ASN A CA   1 
ATOM   1995 C  C    . ASN A 1 106 ? -0.78800  -30.21700 5.83700   1.000 16.98124 ? 106 ASN A C    1 
ATOM   1996 O  O    . ASN A 1 106 ? -1.97000  -30.53700 5.68000   1.000 19.91166 ? 106 ASN A O    1 
ATOM   1997 C  CB   . ASN A 1 106 ? 0.40700   -32.34900 6.32800   1.000 19.37317 ? 106 ASN A CB   1 
ATOM   1998 C  CG   . ASN A 1 106 ? 1.24600   -33.48600 5.77100   1.000 17.63473 ? 106 ASN A CG   1 
ATOM   1999 O  OD1  . ASN A 1 106 ? 0.92300   -34.11600 4.77400   1.000 20.45985 ? 106 ASN A OD1  1 
ATOM   2000 N  ND2  . ASN A 1 106 ? 2.39000   -33.67600 6.37200   1.000 22.12670 ? 106 ASN A ND2  1 
ATOM   2001 H  H    . ASN A 1 106 ? 2.19800   -30.85700 5.68900   1.000 20.76275 ? 106 ASN A H    1 
ATOM   2002 H  HA   . ASN A 1 106 ? -0.01800  -31.54100 4.50700   1.000 19.68769 ? 106 ASN A HA   1 
ATOM   2003 H  HB2  . ASN A 1 106 ? 0.82800   -32.03700 7.14300   1.000 23.25137 ? 106 ASN A HB2  1 
ATOM   2004 H  HB3  . ASN A 1 106 ? -0.47700  -32.69700 6.52300   1.000 23.25137 ? 106 ASN A HB3  1 
ATOM   2005 H  HD21 . ASN A 1 106 ? 2.91600   -34.30400 6.10700   1.000 26.55561 ? 106 ASN A HD21 1 
ATOM   2006 H  HD22 . ASN A 1 106 ? 2.61800   -33.17400 7.03200   1.000 26.55561 ? 106 ASN A HD22 1 
ATOM   2007 N  N    . ALA A 1 107 ? -0.40300  -29.01800 6.27500   1.000 17.55690 ? 107 ALA A N    1 
ATOM   2008 C  CA   . ALA A 1 107 ? -1.37400  -27.99300 6.63200   1.000 18.83868 ? 107 ALA A CA   1 
ATOM   2009 C  C    . ALA A 1 107 ? -2.19100  -27.53900 5.42700   1.000 19.35978 ? 107 ALA A C    1 
ATOM   2010 O  O    . ALA A 1 107 ? -3.31600  -27.06400 5.60800   1.000 22.25158 ? 107 ALA A O    1 
ATOM   2011 C  CB   . ALA A 1 107 ? -0.64600  -26.77500 7.20200   1.000 26.61722 ? 107 ALA A CB   1 
ATOM   2012 H  H    . ALA A 1 107 ? 0.41600   -28.77500 6.37400   1.000 21.07184 ? 107 ALA A H    1 
ATOM   2013 H  HA   . ALA A 1 107 ? -1.97300  -28.35400 7.30400   1.000 22.60999 ? 107 ALA A HA   1 
ATOM   2014 H  HB1  . ALA A 1 107 ? -1.29500  -26.08200 7.39900   1.000 31.94423 ? 107 ALA A HB1  1 
ATOM   2015 H  HB2  . ALA A 1 107 ? -0.18200  -27.03500 8.01300   1.000 31.94423 ? 107 ALA A HB2  1 
ATOM   2016 H  HB3  . ALA A 1 107 ? -0.00800  -26.45300 6.54500   1.000 31.94423 ? 107 ALA A HB3  1 
ATOM   2017 N  N    . TRP A 1 108 ? -1.68400  -27.70700 4.20900   1.000 16.70651 ? 108 TRP A N    1 
ATOM   2018 C  CA   . TRP A 1 108 ? -2.38800  -27.34600 2.97600   1.000 16.68423 ? 108 TRP A CA   1 
ATOM   2019 C  C    . TRP A 1 108 ? -3.02300  -28.59400 2.39800   1.000 17.93047 ? 108 TRP A C    1 
ATOM   2020 O  O    . TRP A 1 108 ? -2.33300  -29.49500 1.89600   1.000 17.14028 ? 108 TRP A O    1 
ATOM   2021 C  CB   . TRP A 1 108 ? -1.42200  -26.74100 1.97600   1.000 17.04930 ? 108 TRP A CB   1 
ATOM   2022 C  CG   . TRP A 1 108 ? -1.05600  -25.33300 2.34300   1.000 16.28708 ? 108 TRP A CG   1 
ATOM   2023 C  CD1  . TRP A 1 108 ? -1.78000  -24.18400 2.08200   1.000 19.58131 ? 108 TRP A CD1  1 
ATOM   2024 C  CD2  . TRP A 1 108 ? 0.11100   -24.90400 3.03400   1.000 15.81915 ? 108 TRP A CD2  1 
ATOM   2025 N  NE1  . TRP A 1 108 ? -1.13600  -23.11300 2.58100   1.000 18.78232 ? 108 TRP A NE1  1 
ATOM   2026 C  CE2  . TRP A 1 108 ? 0.05000   -23.49900 3.14700   1.000 17.13632 ? 108 TRP A CE2  1 
ATOM   2027 C  CE3  . TRP A 1 108 ? 1.22300   -25.56200 3.54200   1.000 19.67419 ? 108 TRP A CE3  1 
ATOM   2028 C  CZ2  . TRP A 1 108 ? 1.02600   -22.76900 3.77500   1.000 17.72889 ? 108 TRP A CZ2  1 
ATOM   2029 C  CZ3  . TRP A 1 108 ? 2.19700   -24.81700 4.18000   1.000 19.76178 ? 108 TRP A CZ3  1 
ATOM   2030 C  CH2  . TRP A 1 108 ? 2.11100   -23.42700 4.27200   1.000 19.85699 ? 108 TRP A CH2  1 
ATOM   2031 H  H    . TRP A 1 108 ? -0.90500  -28.04100 4.06300   1.000 20.05138 ? 108 TRP A H    1 
ATOM   2032 H  HA   . TRP A 1 108 ? -3.08500  -26.70300 3.18000   1.000 20.02465 ? 108 TRP A HA   1 
ATOM   2033 H  HB2  . TRP A 1 108 ? -0.61000  -27.27100 1.95400   1.000 20.46273 ? 108 TRP A HB2  1 
ATOM   2034 H  HB3  . TRP A 1 108 ? -1.83500  -26.73000 1.09800   1.000 20.46273 ? 108 TRP A HB3  1 
ATOM   2035 H  HD1  . TRP A 1 108 ? -2.59200  -24.15600 1.62900   1.000 23.50114 ? 108 TRP A HD1  1 
ATOM   2036 H  HE1  . TRP A 1 108 ? -1.42600  -22.30400 2.54900   1.000 22.54236 ? 108 TRP A HE1  1 
ATOM   2037 H  HE3  . TRP A 1 108 ? 1.31100   -26.48400 3.45400   1.000 23.61259 ? 108 TRP A HE3  1 
ATOM   2038 H  HZ2  . TRP A 1 108 ? 0.94900   -21.84600 3.85900   1.000 21.27824 ? 108 TRP A HZ2  1 
ATOM   2039 H  HZ3  . TRP A 1 108 ? 2.92700   -25.25200 4.55600   1.000 23.71770 ? 108 TRP A HZ3  1 
ATOM   2040 H  HH2  . TRP A 1 108 ? 2.79800   -22.94700 4.67500   1.000 23.83196 ? 108 TRP A HH2  1 
ATOM   2041 N  N    A VAL A 1 109 ? -4.35500  -28.63200 2.45200   0.540 19.07447 ? 109 VAL A N    1 
ATOM   2042 N  N    B VAL A 1 109 ? -4.34700  -28.66300 2.45200   0.460 19.21617 ? 109 VAL A N    1 
ATOM   2043 C  CA   A VAL A 1 109 ? -5.09500  -29.82300 2.04100   0.540 21.92318 ? 109 VAL A CA   1 
ATOM   2044 C  CA   B VAL A 1 109 ? -5.00300  -29.90500 2.05700   0.460 21.09146 ? 109 VAL A CA   1 
ATOM   2045 C  C    A VAL A 1 109 ? -4.80700  -30.15900 0.59100   0.540 17.84074 ? 109 VAL A C    1 
ATOM   2046 C  C    B VAL A 1 109 ? -4.79500  -30.18600 0.57200   0.460 17.97842 ? 109 VAL A C    1 
ATOM   2047 O  O    A VAL A 1 109 ? -4.59000  -31.32900 0.24300   0.540 18.51296 ? 109 VAL A O    1 
ATOM   2048 O  O    B VAL A 1 109 ? -4.62600  -31.34400 0.17300   0.460 18.63652 ? 109 VAL A O    1 
ATOM   2049 C  CB   A VAL A 1 109 ? -6.59900  -29.60500 2.30200   0.540 19.43591 ? 109 VAL A CB   1 
ATOM   2050 C  CB   B VAL A 1 109 ? -6.49100  -29.86800 2.45200   0.460 28.31943 ? 109 VAL A CB   1 
ATOM   2051 C  CG1  A VAL A 1 109 ? -7.42000  -30.70700 1.67000   0.540 22.37401 ? 109 VAL A CG1  1 
ATOM   2052 C  CG1  B VAL A 1 109 ? -7.21200  -28.80100 1.63800   0.460 24.68156 ? 109 VAL A CG1  1 
ATOM   2053 C  CG2  A VAL A 1 109 ? -6.84700  -29.56800 3.80300   0.540 27.64873 ? 109 VAL A CG2  1 
ATOM   2054 C  CG2  B VAL A 1 109 ? -7.10300  -31.26000 2.31100   0.460 25.06995 ? 109 VAL A CG2  1 
ATOM   2055 H  H    A VAL A 1 109 ? -4.85200  -27.98400 2.72200   0.540 22.89293 ? 109 VAL A H    1 
ATOM   2056 H  H    B VAL A 1 109 ? -4.87200  -28.03000 2.70400   0.460 23.06297 ? 109 VAL A H    1 
ATOM   2057 H  HA   A VAL A 1 109 ? -4.80000  -30.58000 2.57100   0.540 26.31139 ? 109 VAL A HA   1 
ATOM   2058 H  HA   B VAL A 1 109 ? -4.59200  -30.63900 2.54000   0.460 25.31332 ? 109 VAL A HA   1 
ATOM   2059 H  HB   A VAL A 1 109 ? -6.87400  -28.76300 1.90700   0.540 23.32666 ? 109 VAL A HB   1 
ATOM   2060 H  HB   B VAL A 1 109 ? -6.59600  -29.61900 3.38400   0.460 33.98689 ? 109 VAL A HB   1 
ATOM   2061 H  HG11 A VAL A 1 109 ? -8.31400  -30.68900 2.04500   0.540 26.85238 ? 109 VAL A HG11 1 
ATOM   2062 H  HG11 B VAL A 1 109 ? -6.55300  -28.23600 1.20600   0.460 29.62144 ? 109 VAL A HG11 1 
ATOM   2063 H  HG12 A VAL A 1 109 ? -7.45900  -30.56100 0.71200   0.540 26.85238 ? 109 VAL A HG12 1 
ATOM   2064 H  HG12 B VAL A 1 109 ? -7.76600  -29.23500 0.97000   0.460 29.62144 ? 109 VAL A HG12 1 
ATOM   2065 H  HG13 A VAL A 1 109 ? -7.00000  -31.56100 1.85800   0.540 26.85238 ? 109 VAL A HG13 1 
ATOM   2066 H  HG13 B VAL A 1 109 ? -7.76500  -28.27100 2.23300   0.460 29.62144 ? 109 VAL A HG13 1 
ATOM   2067 H  HG21 A VAL A 1 109 ? -7.79300  -29.43000 3.96300   0.540 33.18204 ? 109 VAL A HG21 1 
ATOM   2068 H  HG21 B VAL A 1 109 ? -7.96100  -31.27600 2.76400   0.460 30.08751 ? 109 VAL A HG21 1 
ATOM   2069 H  HG22 A VAL A 1 109 ? -6.56600  -30.41200 4.19000   0.540 33.18204 ? 109 VAL A HG22 1 
ATOM   2070 H  HG22 B VAL A 1 109 ? -7.22400  -31.45800 1.36900   0.460 30.08751 ? 109 VAL A HG22 1 
ATOM   2071 H  HG23 A VAL A 1 109 ? -6.33600  -28.84000 4.18900   0.540 33.18204 ? 109 VAL A HG23 1 
ATOM   2072 H  HG23 B VAL A 1 109 ? -6.50500  -31.91000 2.71200   0.460 30.08751 ? 109 VAL A HG23 1 
ATOM   2073 N  N    . ALA A 1 110 ? -4.76700  -29.15100 -0.27100  1.000 18.20949 ? 110 ALA A N    1 
ATOM   2074 C  CA   . ALA A 1 110 ? -4.52500  -29.41800 -1.68100  1.000 18.23870 ? 110 ALA A CA   1 
ATOM   2075 C  C    . ALA A 1 110 ? -3.12800  -29.96100 -1.90500  1.000 19.34609 ? 110 ALA A C    1 
ATOM   2076 O  O    . ALA A 1 110 ? -2.92600  -30.79600 -2.79200  1.000 19.66043 ? 110 ALA A O    1 
ATOM   2077 C  CB   . ALA A 1 110 ? -4.72000  -28.16400 -2.52400  1.000 24.73084 ? 110 ALA A CB   1 
ATOM   2078 H  H    . ALA A 1 110 ? -4.87600  -28.32300 -0.06700  1.000 21.85496 ? 110 ALA A H    1 
ATOM   2079 H  HA   . ALA A 1 110 ? -5.17600  -30.07400 -1.97500  1.000 21.89001 ? 110 ALA A HA   1 
ATOM   2080 H  HB1  . ALA A 1 110 ? -4.50300  -28.36700 -3.44700  1.000 29.68057 ? 110 ALA A HB1  1 
ATOM   2081 H  HB2  . ALA A 1 110 ? -5.64500  -27.88000 -2.45700  1.000 29.68057 ? 110 ALA A HB2  1 
ATOM   2082 H  HB3  . ALA A 1 110 ? -4.13400  -27.46600 -2.19200  1.000 29.68057 ? 110 ALA A HB3  1 
ATOM   2083 N  N    . TRP A 1 111 ? -2.15000  -29.53200 -1.10900  1.000 16.99398 ? 111 TRP A N    1 
ATOM   2084 C  CA   . TRP A 1 111 ? -0.82100  -30.11200 -1.24700  1.000 17.38792 ? 111 TRP A CA   1 
ATOM   2085 C  C    . TRP A 1 111 ? -0.84500  -31.58900 -0.90500  1.000 17.32929 ? 111 TRP A C    1 
ATOM   2086 O  O    . TRP A 1 111 ? -0.31500  -32.42000 -1.65300  1.000 16.72796 ? 111 TRP A O    1 
ATOM   2087 C  CB   . TRP A 1 111 ? 0.20700   -29.37700 -0.37600  1.000 17.37767 ? 111 TRP A CB   1 
ATOM   2088 C  CG   . TRP A 1 111 ? 1.57500   -29.96700 -0.49700  1.000 16.18557 ? 111 TRP A CG   1 
ATOM   2089 C  CD1  . TRP A 1 111 ? 2.51300   -29.71700 -1.47400  1.000 18.10833 ? 111 TRP A CD1  1 
ATOM   2090 C  CD2  . TRP A 1 111 ? 2.13800   -30.96600 0.34600   1.000 15.64317 ? 111 TRP A CD2  1 
ATOM   2091 N  NE1  . TRP A 1 111 ? 3.60800   -30.51900 -1.27900  1.000 18.57287 ? 111 TRP A NE1  1 
ATOM   2092 C  CE2  . TRP A 1 111 ? 3.42400   -31.27900 -0.15900  1.000 16.28215 ? 111 TRP A CE2  1 
ATOM   2093 C  CE3  . TRP A 1 111 ? 1.69500   -31.63200 1.49900   1.000 16.24987 ? 111 TRP A CE3  1 
ATOM   2094 C  CZ2  . TRP A 1 111 ? 4.26300   -32.20500 0.47100   1.000 18.35098 ? 111 TRP A CZ2  1 
ATOM   2095 C  CZ3  . TRP A 1 111 ? 2.52100   -32.52600 2.10900   1.000 19.15136 ? 111 TRP A CZ3  1 
ATOM   2096 C  CH2  . TRP A 1 111 ? 3.78300   -32.81700 1.59300   1.000 18.76331 ? 111 TRP A CH2  1 
ATOM   2097 H  H    . TRP A 1 111 ? -2.22900  -28.92700 -0.50300  1.000 20.39635 ? 111 TRP A H    1 
ATOM   2098 H  HA   . TRP A 1 111 ? -0.54100  -30.00400 -2.16900  1.000 20.86907 ? 111 TRP A HA   1 
ATOM   2099 H  HB2  . TRP A 1 111 ? 0.25300   -28.44800 -0.65300  1.000 20.85677 ? 111 TRP A HB2  1 
ATOM   2100 H  HB3  . TRP A 1 111 ? -0.06500  -29.43300 0.55300   1.000 20.85677 ? 111 TRP A HB3  1 
ATOM   2101 H  HD1  . TRP A 1 111 ? 2.41800   -29.09700 -2.16100  1.000 21.73356 ? 111 TRP A HD1  1 
ATOM   2102 H  HE1  . TRP A 1 111 ? 4.30400   -30.54100 -1.78400  1.000 22.29101 ? 111 TRP A HE1  1 
ATOM   2103 H  HE3  . TRP A 1 111 ? 0.84700   -31.46400 1.84300   1.000 19.50341 ? 111 TRP A HE3  1 
ATOM   2104 H  HZ2  . TRP A 1 111 ? 5.11100   -32.39500 0.14000   1.000 22.02474 ? 111 TRP A HZ2  1 
ATOM   2105 H  HZ3  . TRP A 1 111 ? 2.23700   -32.95200 2.88600   1.000 22.98520 ? 111 TRP A HZ3  1 
ATOM   2106 H  HH2  . TRP A 1 111 ? 4.31300   -33.44600 2.02600   1.000 22.51954 ? 111 TRP A HH2  1 
ATOM   2107 N  N    A ARG A 1 112 ? -1.44400  -31.96400 0.23100   0.470 15.90929 ? 112 ARG A N    1 
ATOM   2108 N  N    B ARG A 1 112 ? -1.48900  -31.94500 0.20000   0.530 15.87996 ? 112 ARG A N    1 
ATOM   2109 C  CA   A ARG A 1 112 ? -1.50700  -33.37600 0.59400   0.470 18.01262 ? 112 ARG A CA   1 
ATOM   2110 C  CA   B ARG A 1 112 ? -1.50500  -33.32900 0.63300   0.530 17.96447 ? 112 ARG A CA   1 
ATOM   2111 C  C    A ARG A 1 112 ? -2.16600  -34.18000 -0.51300  0.470 16.56982 ? 112 ARG A C    1 
ATOM   2112 C  C    B ARG A 1 112 ? -2.23200  -34.20700 -0.36800  0.530 16.81875 ? 112 ARG A C    1 
ATOM   2113 O  O    A ARG A 1 112 ? -1.68500  -35.25100 -0.90700  0.470 19.55069 ? 112 ARG A O    1 
ATOM   2114 O  O    B ARG A 1 112 ? -1.84400  -35.36900 -0.55800  0.530 18.73314 ? 112 ARG A O    1 
ATOM   2115 C  CB   A ARG A 1 112 ? -2.35800  -33.58200 1.85200   0.470 22.68076 ? 112 ARG A CB   1 
ATOM   2116 C  CB   B ARG A 1 112 ? -2.18800  -33.42500 2.00100   0.530 21.44330 ? 112 ARG A CB   1 
ATOM   2117 C  CG   A ARG A 1 112 ? -1.83300  -33.05100 3.14800   0.470 35.11865 ? 112 ARG A CG   1 
ATOM   2118 C  CG   B ARG A 1 112 ? -2.25000  -34.81900 2.59200   0.530 22.55881 ? 112 ARG A CG   1 
ATOM   2119 C  CD   A ARG A 1 112 ? -2.63400  -33.64400 4.33400   0.470 33.72575 ? 112 ARG A CD   1 
ATOM   2120 C  CD   B ARG A 1 112 ? -2.53100  -34.78500 4.10800   0.530 31.85849 ? 112 ARG A CD   1 
ATOM   2121 N  NE   A ARG A 1 112 ? -3.83400  -34.37900 3.92600   0.470 26.33190 ? 112 ARG A NE   1 
ATOM   2122 N  NE   B ARG A 1 112 ? -3.02100  -33.49200 4.58400   0.530 40.56844 ? 112 ARG A NE   1 
ATOM   2123 C  CZ   A ARG A 1 112 ? -3.92000  -35.70100 3.80700   0.470 46.47044 ? 112 ARG A CZ   1 
ATOM   2124 C  CZ   B ARG A 1 112 ? -4.29300  -33.10700 4.60200   0.530 32.82707 ? 112 ARG A CZ   1 
ATOM   2125 N  NH1  A ARG A 1 112 ? -2.91600  -36.49600 4.14400   0.470 43.41725 ? 112 ARG A NH1  1 
ATOM   2126 N  NH1  B ARG A 1 112 ? -5.26900  -33.90800 4.20500   0.530 44.51223 ? 112 ARG A NH1  1 
ATOM   2127 N  NH2  A ARG A 1 112 ? -5.03900  -36.23800 3.32000   0.470 35.57193 ? 112 ARG A NH2  1 
ATOM   2128 N  NH2  B ARG A 1 112 ? -4.59400  -31.89000 5.05100   0.530 29.06785 ? 112 ARG A NH2  1 
ATOM   2129 H  H    A ARG A 1 112 ? -1.81300  -31.42900 0.79500   0.470 19.09472 ? 112 ARG A H    1 
ATOM   2130 H  H    B ARG A 1 112 ? -1.92200  -31.40600 0.71300   0.530 19.05951 ? 112 ARG A H    1 
ATOM   2131 H  HA   A ARG A 1 112 ? -0.59800  -33.67200 0.75600   0.470 21.61872 ? 112 ARG A HA   1 
ATOM   2132 H  HA   B ARG A 1 112 ? -0.59400  -33.65000 0.71700   0.530 21.56094 ? 112 ARG A HA   1 
ATOM   2133 H  HB2  A ARG A 1 112 ? -3.21500  -33.15300 1.70200   0.470 27.22048 ? 112 ARG A HB2  1 
ATOM   2134 H  HB2  B ARG A 1 112 ? -1.70100  -32.86600 2.62700   0.530 25.73553 ? 112 ARG A HB2  1 
ATOM   2135 H  HB3  A ARG A 1 112 ? -2.48100  -34.53700 1.97200   0.470 27.22048 ? 112 ARG A HB3  1 
ATOM   2136 H  HB3  B ARG A 1 112 ? -3.10000  -33.10600 1.91200   0.530 25.73553 ? 112 ARG A HB3  1 
ATOM   2137 H  HG2  A ARG A 1 112 ? -0.90100  -33.29900 3.24900   0.470 42.14595 ? 112 ARG A HG2  1 
ATOM   2138 H  HG2  B ARG A 1 112 ? -2.96300  -35.31700 2.16200   0.530 27.07414 ? 112 ARG A HG2  1 
ATOM   2139 H  HG3  A ARG A 1 112 ? -1.92300  -32.08500 3.16600   0.470 42.14595 ? 112 ARG A HG3  1 
ATOM   2140 H  HG3  B ARG A 1 112 ? -1.40100  -35.26500 2.45000   0.530 27.07414 ? 112 ARG A HG3  1 
ATOM   2141 H  HD2  A ARG A 1 112 ? -2.06300  -34.25800 4.82100   0.470 40.47447 ? 112 ARG A HD2  1 
ATOM   2142 H  HD2  B ARG A 1 112 ? -3.20400  -35.45200 4.31600   0.530 38.23376 ? 112 ARG A HD2  1 
ATOM   2143 H  HD3  A ARG A 1 112 ? -2.91400  -32.92000 4.91500   0.470 40.47447 ? 112 ARG A HD3  1 
ATOM   2144 H  HD3  B ARG A 1 112 ? -1.70900  -34.98400 4.58300   0.530 38.23376 ? 112 ARG A HD3  1 
ATOM   2145 H  HE   A ARG A 1 112 ? -4.53900  -33.91900 3.75000   0.470 31.60184 ? 112 ARG A HE   1 
ATOM   2146 H  HE   B ARG A 1 112 ? -2.43600  -32.93300 4.87700   0.530 48.68569 ? 112 ARG A HE   1 
ATOM   2147 H  HH11 A ARG A 1 112 ? -2.18500  -36.16100 4.44800   0.470 52.10427 ? 112 ARG A HH11 1 
ATOM   2148 H  HH11 B ARG A 1 112 ? -5.08700  -34.70100 3.92700   0.530 53.41825 ? 112 ARG A HH11 1 
ATOM   2149 H  HH12 A ARG A 1 112 ? -2.99400  -37.34800 4.05800   0.470 52.10427 ? 112 ARG A HH12 1 
ATOM   2150 H  HH12 B ARG A 1 112 ? -6.08400  -33.63600 4.22600   0.530 53.41825 ? 112 ARG A HH12 1 
ATOM   2151 H  HH21 A ARG A 1 112 ? -5.69300  -35.73100 3.08700   0.470 42.68988 ? 112 ARG A HH21 1 
ATOM   2152 H  HH21 B ARG A 1 112 ? -3.97000  -31.36600 5.32400   0.530 34.88499 ? 112 ARG A HH21 1 
ATOM   2153 H  HH22 A ARG A 1 112 ? -5.10700  -37.09200 3.23800   0.470 42.68988 ? 112 ARG A HH22 1 
ATOM   2154 H  HH22 B ARG A 1 112 ? -5.41300  -31.62800 5.06800   0.530 34.88499 ? 112 ARG A HH22 1 
ATOM   2155 N  N    . ASN A 1 113 ? -3.28200  -33.67800 -1.02900  1.000 17.67648 ? 113 ASN A N    1 
ATOM   2156 C  CA   . ASN A 1 113 ? -4.11800  -34.50900 -1.88300  1.000 19.41395 ? 113 ASN A CA   1 
ATOM   2157 C  C    . ASN A 1 113 ? -3.69700  -34.50300 -3.33700  1.000 20.85999 ? 113 ASN A C    1 
ATOM   2158 O  O    . ASN A 1 113 ? -4.03600  -35.45100 -4.07200  1.000 22.31826 ? 113 ASN A O    1 
ATOM   2159 C  CB   . ASN A 1 113 ? -5.57500  -34.09800 -1.75100  1.000 19.15646 ? 113 ASN A CB   1 
ATOM   2160 C  CG   . ASN A 1 113 ? -6.15400  -34.51400 -0.43300  1.000 19.34660 ? 113 ASN A CG   1 
ATOM   2161 O  OD1  . ASN A 1 113 ? -5.72000  -35.50600 0.15900   1.000 24.30015 ? 113 ASN A OD1  1 
ATOM   2162 N  ND2  . ASN A 1 113 ? -7.15000  -33.77800 0.03600   1.000 20.46590 ? 113 ASN A ND2  1 
ATOM   2163 H  H    . ASN A 1 113 ? -3.51700  -32.85200 -0.99200  1.000 21.21534 ? 113 ASN A H    1 
ATOM   2164 H  HA   . ASN A 1 113 ? -4.05200  -35.42800 -1.58000  1.000 23.30031 ? 113 ASN A HA   1 
ATOM   2165 H  HB2  . ASN A 1 113 ? -5.64300  -33.13300 -1.82200  1.000 22.99132 ? 113 ASN A HB2  1 
ATOM   2166 H  HB3  . ASN A 1 113 ? -6.09100  -34.51900 -2.45600  1.000 22.99132 ? 113 ASN A HB3  1 
ATOM   2167 H  HD21 . ASN A 1 113 ? -7.51500  -33.97800 0.78900   1.000 24.56264 ? 113 ASN A HD21 1 
ATOM   2168 H  HD22 . ASN A 1 113 ? -7.43300  -33.10100 -0.41300  1.000 24.56264 ? 113 ASN A HD22 1 
ATOM   2169 N  N    . ARG A 1 114 ? -2.93400  -33.50000 -3.78000  1.000 18.09343 ? 114 ARG A N    1 
ATOM   2170 C  CA   . ARG A 1 114 ? -2.64400  -33.30200 -5.19200  1.000 20.99315 ? 114 ARG A CA   1 
ATOM   2171 C  C    . ARG A 1 114 ? -1.17800  -33.11200 -5.51200  1.000 21.53452 ? 114 ARG A C    1 
ATOM   2172 O  O    . ARG A 1 114 ? -0.82200  -33.17300 -6.69600  1.000 22.76375 ? 114 ARG A O    1 
ATOM   2173 C  CB   . ARG A 1 114 ? -3.42400  -32.11100 -5.71500  1.000 21.03663 ? 114 ARG A CB   1 
ATOM   2174 C  CG   . ARG A 1 114 ? -4.90200  -32.35600 -5.40500  1.000 23.26333 ? 114 ARG A CG   1 
ATOM   2175 C  CD   . ARG A 1 114 ? -5.74600  -31.31300 -5.94300  1.000 26.53087 ? 114 ARG A CD   1 
ATOM   2176 N  NE   . ARG A 1 114 ? -5.89200  -31.38500 -7.38600  1.000 21.65145 ? 114 ARG A NE   1 
ATOM   2177 C  CZ   . ARG A 1 114 ? -6.66100  -30.54500 -8.05500  1.000 22.23961 ? 114 ARG A CZ   1 
ATOM   2178 N  NH1  . ARG A 1 114 ? -7.31300  -29.58900 -7.42900  1.000 21.98327 ? 114 ARG A NH1  1 
ATOM   2179 N  NH2  . ARG A 1 114 ? -6.77100  -30.67500 -9.37000  1.000 24.07183 ? 114 ARG A NH2  1 
ATOM   2180 H  H    . ARG A 1 114 ? -2.56900  -32.91300 -3.26900  1.000 21.71568 ? 114 ARG A H    1 
ATOM   2181 H  HA   . ARG A 1 114 ? -2.93300  -34.09000 -5.67900  1.000 25.19535 ? 114 ARG A HA   1 
ATOM   2182 H  HB2  . ARG A 1 114 ? -3.13200  -31.29800 -5.27300  1.000 25.24752 ? 114 ARG A HB2  1 
ATOM   2183 H  HB3  . ARG A 1 114 ? -3.30600  -32.02800 -6.67500  1.000 25.24752 ? 114 ARG A HB3  1 
ATOM   2184 H  HG2  . ARG A 1 114 ? -5.17500  -33.20000 -5.79700  1.000 27.91957 ? 114 ARG A HG2  1 
ATOM   2185 H  HG3  . ARG A 1 114 ? -5.02700  -32.38100 -4.44300  1.000 27.91957 ? 114 ARG A HG3  1 
ATOM   2186 H  HD2  . ARG A 1 114 ? -6.63000  -31.38900 -5.55000  1.000 31.84061 ? 114 ARG A HD2  1 
ATOM   2187 H  HD3  . ARG A 1 114 ? -5.35900  -30.45100 -5.72500  1.000 31.84061 ? 114 ARG A HD3  1 
ATOM   2188 H  HE   . ARG A 1 114 ? -5.46400  -31.99300 -7.81800  1.000 25.98531 ? 114 ARG A HE   1 
ATOM   2189 H  HH11 . ARG A 1 114 ? -7.24100  -29.50600 -6.57600  1.000 26.38349 ? 114 ARG A HH11 1 
ATOM   2190 H  HH12 . ARG A 1 114 ? -7.81100  -29.04600 -7.87300  1.000 26.38349 ? 114 ARG A HH12 1 
ATOM   2191 H  HH21 . ARG A 1 114 ? -6.34500  -31.30100 -9.77800  1.000 28.88977 ? 114 ARG A HH21 1 
ATOM   2192 H  HH22 . ARG A 1 114 ? -7.26900  -30.13400 -9.81600  1.000 28.88977 ? 114 ARG A HH22 1 
ATOM   2193 N  N    . CYS A 1 115 ? -0.31700  -32.88900 -4.52200  1.000 16.30519 ? 115 CYS A N    1 
ATOM   2194 C  CA   . CYS A 1 115 ? 1.09700   -32.68800 -4.76400  1.000 17.22387 ? 115 CYS A CA   1 
ATOM   2195 C  C    . CYS A 1 115 ? 1.97200   -33.71200 -4.08600  1.000 19.05115 ? 115 CYS A C    1 
ATOM   2196 O  O    . CYS A 1 115 ? 2.94100   -34.18400 -4.69200  1.000 20.19477 ? 115 CYS A O    1 
ATOM   2197 C  CB   . CYS A 1 115 ? 1.50200   -31.29700 -4.25600  1.000 15.89580 ? 115 CYS A CB   1 
ATOM   2198 S  SG   . CYS A 1 115 ? 0.58600   -29.94100 -5.04200  1.000 17.39487 ? 115 CYS A SG   1 
ATOM   2199 H  H    . CYS A 1 115 ? -0.53700  -32.85100 -3.69100  1.000 19.56979 ? 115 CYS A H    1 
ATOM   2200 H  HA   . CYS A 1 115 ? 1.25900   -32.74200 -5.71900  1.000 20.67222 ? 115 CYS A HA   1 
ATOM   2201 H  HB2  . CYS A 1 115 ? 1.33800   -31.25300 -3.30200  1.000 19.07852 ? 115 CYS A HB2  1 
ATOM   2202 H  HB3  . CYS A 1 115 ? 2.44600   -31.16200 -4.43700  1.000 19.07852 ? 115 CYS A HB3  1 
ATOM   2203 N  N    . LYS A 1 116 ? 1.67500   -34.04900 -2.83900  1.000 18.35631 ? 116 LYS A N    1 
ATOM   2204 C  CA   . LYS A 1 116 ? 2.49400   -34.97200 -2.06200  1.000 19.91860 ? 116 LYS A CA   1 
ATOM   2205 C  C    . LYS A 1 116 ? 2.61000   -36.30300 -2.78500  1.000 20.69847 ? 116 LYS A C    1 
ATOM   2206 O  O    . LYS A 1 116 ? 1.60900   -36.87700 -3.20000  1.000 21.05501 ? 116 LYS A O    1 
ATOM   2207 C  CB   . LYS A 1 116 ? 1.81700   -35.17500 -0.70900  1.000 19.98632 ? 116 LYS A CB   1 
ATOM   2208 C  CG   . LYS A 1 116 ? 2.59800   -36.01100 0.27300   1.000 19.43342 ? 116 LYS A CG   1 
ATOM   2209 C  CD   . LYS A 1 116 ? 1.83400   -36.14200 1.56300   1.000 20.08047 ? 116 LYS A CD   1 
ATOM   2210 C  CE   . LYS A 1 116 ? 2.65500   -36.79300 2.67000   1.000 21.80574 ? 116 LYS A CE   1 
ATOM   2211 N  NZ   . LYS A 1 116 ? 1.88700   -36.82600 3.96300   1.000 23.74620 ? 116 LYS A NZ   1 
ATOM   2212 H  H    . LYS A 1 116 ? 0.99200   -33.75200 -2.40900  1.000 22.03114 ? 116 LYS A H    1 
ATOM   2213 H  HA   . LYS A 1 116 ? 3.38900   -34.61800 -1.93700  1.000 23.90589 ? 116 LYS A HA   1 
ATOM   2214 H  HB2  . LYS A 1 116 ? 1.67500   -34.30600 -0.30200  1.000 23.98715 ? 116 LYS A HB2  1 
ATOM   2215 H  HB3  . LYS A 1 116 ? 0.96500   -35.61600 -0.85400  1.000 23.98715 ? 116 LYS A HB3  1 
ATOM   2216 H  HG2  . LYS A 1 116 ? 2.74100   -36.89700 -0.09500  1.000 23.32368 ? 116 LYS A HG2  1 
ATOM   2217 H  HG3  . LYS A 1 116 ? 3.45000   -35.58700 0.45800   1.000 23.32368 ? 116 LYS A HG3  1 
ATOM   2218 H  HD2  . LYS A 1 116 ? 1.57000   -35.26000 1.86500   1.000 24.10013 ? 116 LYS A HD2  1 
ATOM   2219 H  HD3  . LYS A 1 116 ? 1.04900   -36.69100 1.41100   1.000 24.10013 ? 116 LYS A HD3  1 
ATOM   2220 H  HE2  . LYS A 1 116 ? 2.87200   -37.70400 2.41900   1.000 26.17045 ? 116 LYS A HE2  1 
ATOM   2221 H  HE3  . LYS A 1 116 ? 3.46900   -36.28400 2.81000   1.000 26.17045 ? 116 LYS A HE3  1 
ATOM   2222 H  HZ1  . LYS A 1 116 ? 2.34200   -37.28200 4.57700   1.000 28.49900 ? 116 LYS A HZ1  1 
ATOM   2223 H  HZ2  . LYS A 1 116 ? 1.75300   -35.99700 4.25900   1.000 28.49900 ? 116 LYS A HZ2  1 
ATOM   2224 H  HZ3  . LYS A 1 116 ? 1.09800   -37.21800 3.83800   1.000 28.49900 ? 116 LYS A HZ3  1 
ATOM   2225 N  N    . GLY A 1 117 ? 3.84100   -36.74800 -2.97900  1.000 23.96809 ? 117 GLY A N    1 
ATOM   2226 C  CA   . GLY A 1 117 ? 4.08300   -38.03700 -3.61400  1.000 25.92824 ? 117 GLY A CA   1 
ATOM   2227 C  C    . GLY A 1 117 ? 4.01200   -38.02900 -5.12200  1.000 31.26205 ? 117 GLY A C    1 
ATOM   2228 O  O    . GLY A 1 117 ? 3.94400   -39.10200 -5.73500  1.000 36.36349 ? 117 GLY A O    1 
ATOM   2229 H  H    . GLY A 1 117 ? 4.55500   -36.32400 -2.75200  1.000 28.76527 ? 117 GLY A H    1 
ATOM   2230 H  HA2  . GLY A 1 117 ? 4.96800   -38.34600 -3.36200  1.000 31.11746 ? 117 GLY A HA2  1 
ATOM   2231 H  HA3  . GLY A 1 117 ? 3.42400   -38.67100 -3.29000  1.000 31.11746 ? 117 GLY A HA3  1 
ATOM   2232 N  N    . THR A 1 118 ? 4.00800   -36.86200 -5.73900  1.000 24.22781 ? 118 THR A N    1 
ATOM   2233 C  CA   . THR A 1 118 ? 4.02400   -36.71500 -7.18400  1.000 23.25516 ? 118 THR A CA   1 
ATOM   2234 C  C    . THR A 1 118 ? 5.35300   -36.08100 -7.57500  1.000 24.09984 ? 118 THR A C    1 
ATOM   2235 O  O    . THR A 1 118 ? 6.14400   -35.65400 -6.73200  1.000 24.91838 ? 118 THR A O    1 
ATOM   2236 C  CB   . THR A 1 118 ? 2.86700   -35.85000 -7.68400  1.000 25.25179 ? 118 THR A CB   1 
ATOM   2237 O  OG1  . THR A 1 118 ? 3.13500   -34.47200 -7.37400  1.000 24.70418 ? 118 THR A OG1  1 
ATOM   2238 C  CG2  . THR A 1 118 ? 1.56200   -36.24600 -7.04900  1.000 24.82138 ? 118 THR A CG2  1 
ATOM   2239 H  H    . THR A 1 118 ? 3.99500   -36.10800 -5.32600  1.000 29.07694 ? 118 THR A H    1 
ATOM   2240 H  HA   . THR A 1 118 ? 3.92700   -37.58500 -7.60200  1.000 27.90976 ? 118 THR A HA   1 
ATOM   2241 H  HB   . THR A 1 118 ? 2.78000   -35.97200 -8.64200  1.000 30.30572 ? 118 THR A HB   1 
ATOM   2242 H  HG1  . THR A 1 118 ? 3.43800   -34.40700 -6.59300  1.000 29.64859 ? 118 THR A HG1  1 
ATOM   2243 H  HG21 . THR A 1 118 ? 0.84500   -35.68900 -7.39100  1.000 29.78922 ? 118 THR A HG21 1 
ATOM   2244 H  HG22 . THR A 1 118 ? 1.36300   -37.17400 -7.25000  1.000 29.78922 ? 118 THR A HG22 1 
ATOM   2245 H  HG23 . THR A 1 118 ? 1.61400   -36.13600 -6.08700  1.000 29.78922 ? 118 THR A HG23 1 
ATOM   2246 N  N    . ASP A 1 119 ? 5.59200   -36.02400 -8.88200  1.000 28.56097 ? 119 ASP A N    1 
ATOM   2247 C  CA   . ASP A 1 119 ? 6.84600   -35.46700 -9.38900  1.000 28.04531 ? 119 ASP A CA   1 
ATOM   2248 C  C    . ASP A 1 119 ? 6.70000   -33.95100 -9.38700  1.000 28.32899 ? 119 ASP A C    1 
ATOM   2249 O  O    . ASP A 1 119 ? 6.37000   -33.32000 -10.39100 1.000 29.84590 ? 119 ASP A O    1 
ATOM   2250 C  CB   . ASP A 1 119 ? 7.13700   -36.01300 -10.78200 1.000 35.43878 ? 119 ASP A CB   1 
ATOM   2251 C  CG   . ASP A 1 119 ? 8.37300   -35.40100 -11.38900 1.000 50.95282 ? 119 ASP A CG   1 
ATOM   2252 O  OD1  . ASP A 1 119 ? 9.26800   -34.99500 -10.61400 1.000 43.54424 ? 119 ASP A OD1  1 
ATOM   2253 O  OD2  . ASP A 1 119 ? 8.43800   -35.32200 -12.63600 1.000 49.05078 ? 119 ASP A OD2  1 
ATOM   2254 H  H    . ASP A 1 119 ? 5.05000   -36.29800 -9.49100  1.000 34.27673 ? 119 ASP A H    1 
ATOM   2255 H  HA   . ASP A 1 119 ? 7.58500   -35.71200 -8.81100  1.000 33.65794 ? 119 ASP A HA   1 
ATOM   2256 H  HB2  . ASP A 1 119 ? 7.27100   -36.97200 -10.72500 1.000 42.53010 ? 119 ASP A HB2  1 
ATOM   2257 H  HB3  . ASP A 1 119 ? 6.38600   -35.81600 -11.36300 1.000 42.53010 ? 119 ASP A HB3  1 
ATOM   2258 N  N    . VAL A 1 120 ? 6.96400   -33.34500 -8.22200  1.000 25.13218 ? 120 VAL A N    1 
ATOM   2259 C  CA   . VAL A 1 120 ? 6.70400   -31.90500 -8.10400  1.000 23.67767 ? 120 VAL A CA   1 
ATOM   2260 C  C    . VAL A 1 120 ? 7.73400   -31.07000 -8.85300  1.000 24.17919 ? 120 VAL A C    1 
ATOM   2261 O  O    . VAL A 1 120 ? 7.49000   -29.88200 -9.11900  1.000 23.93638 ? 120 VAL A O    1 
ATOM   2262 C  CB   . VAL A 1 120 ? 6.62600   -31.46700 -6.63100  1.000 24.03333 ? 120 VAL A CB   1 
ATOM   2263 C  CG1  . VAL A 1 120 ? 5.42200   -32.08900 -5.93000  1.000 27.16241 ? 120 VAL A CG1  1 
ATOM   2264 C  CG2  . VAL A 1 120 ? 7.86100   -31.83800 -5.89700  1.000 27.47406 ? 120 VAL A CG2  1 
ATOM   2265 H  H    . VAL A 1 120 ? 7.27800   -33.72700 -7.51800  1.000 30.16219 ? 120 VAL A H    1 
ATOM   2266 H  HA   . VAL A 1 120 ? 5.83700   -31.74000 -8.50800  1.000 28.41678 ? 120 VAL A HA   1 
ATOM   2267 H  HB   . VAL A 1 120 ? 6.53000   -30.50200 -6.62100  1.000 28.84357 ? 120 VAL A HB   1 
ATOM   2268 H  HG11 . VAL A 1 120 ? 5.41700   -31.80700 -5.00200  1.000 32.59846 ? 120 VAL A HG11 1 
ATOM   2269 H  HG12 . VAL A 1 120 ? 4.61100   -31.79000 -6.37100  1.000 32.59846 ? 120 VAL A HG12 1 
ATOM   2270 H  HG13 . VAL A 1 120 ? 5.49100   -33.05500 -5.98200  1.000 32.59846 ? 120 VAL A HG13 1 
ATOM   2271 H  HG21 . VAL A 1 120 ? 7.79500   -31.51400 -4.98500  1.000 32.97244 ? 120 VAL A HG21 1 
ATOM   2272 H  HG22 . VAL A 1 120 ? 7.95200   -32.80300 -5.90000  1.000 32.97244 ? 120 VAL A HG22 1 
ATOM   2273 H  HG23 . VAL A 1 120 ? 8.62400   -31.43200 -6.33700  1.000 32.97244 ? 120 VAL A HG23 1 
ATOM   2274 N  N    . GLN A 1 121 ? 8.89700   -31.64400 -9.19200  1.000 25.64230 ? 121 GLN A N    1 
ATOM   2275 C  CA   . GLN A 1 121 ? 9.87400   -30.87900 -9.95600  1.000 24.55028 ? 121 GLN A CA   1 
ATOM   2276 C  C    . GLN A 1 121 ? 9.31700   -30.46100 -11.30500 1.000 24.01066 ? 121 GLN A C    1 
ATOM   2277 O  O    . GLN A 1 121 ? 9.77900   -29.47500 -11.88700 1.000 26.20029 ? 121 GLN A O    1 
ATOM   2278 C  CB   . GLN A 1 121 ? 11.17800  -31.67200 -10.13400 1.000 39.56055 ? 121 GLN A CB   1 
ATOM   2279 C  CG   . GLN A 1 121 ? 12.34200  -30.86100 -10.75700 1.000 67.71079 ? 121 GLN A CG   1 
ATOM   2280 C  CD   . GLN A 1 121 ? 12.53100  -31.07300 -12.26000 1.000 96.15310 ? 121 GLN A CD   1 
ATOM   2281 O  OE1  . GLN A 1 121 ? 12.24000  -32.14500 -12.79500 1.000 92.59666 ? 121 GLN A OE1  1 
ATOM   2282 N  NE2  . GLN A 1 121 ? 13.07400  -30.05600 -12.93600 1.000 68.34889 ? 121 GLN A NE2  1 
ATOM   2283 H  H    . GLN A 1 121 ? 9.13100   -32.44800 -8.99600  1.000 30.77433 ? 121 GLN A H    1 
ATOM   2284 H  HA   . GLN A 1 121 ? 10.10400  -30.07900 -9.45800  1.000 29.46391 ? 121 GLN A HA   1 
ATOM   2285 H  HB2  . GLN A 1 121 ? 11.47100  -31.98400 -9.26300  1.000 47.47623 ? 121 GLN A HB2  1 
ATOM   2286 H  HB3  . GLN A 1 121 ? 11.00300  -32.42800 -10.71600 1.000 47.47623 ? 121 GLN A HB3  1 
ATOM   2287 H  HG2  . GLN A 1 121 ? 12.17300  -29.91700 -10.61400 1.000 81.25652 ? 121 GLN A HG2  1 
ATOM   2288 H  HG3  . GLN A 1 121 ? 13.16800  -31.12000 -10.32000 1.000 81.25652 ? 121 GLN A HG3  1 
ATOM   2289 H  HE21 . GLN A 1 121 ? 13.29500  -29.33500 -12.52400 1.000 82.02224 ? 121 GLN A HE21 1 
ATOM   2290 H  HE22 . GLN A 1 121 ? 13.20200  -30.12400 -13.78400 1.000 82.02224 ? 121 GLN A HE22 1 
ATOM   2291 N  N    . ALA A 1 122 ? 8.31500   -31.17000 -11.81900 1.000 24.23431 ? 122 ALA A N    1 
ATOM   2292 C  CA   . ALA A 1 122 ? 7.72900   -30.77900 -13.09200 1.000 26.75532 ? 122 ALA A CA   1 
ATOM   2293 C  C    . ALA A 1 122 ? 7.17900   -29.35900 -13.04800 1.000 27.43782 ? 122 ALA A C    1 
ATOM   2294 O  O    . ALA A 1 122 ? 7.04800   -28.70600 -14.08300 1.000 26.17430 ? 122 ALA A O    1 
ATOM   2295 C  CB   . ALA A 1 122 ? 6.61600   -31.74200 -13.49200 1.000 32.70251 ? 122 ALA A CB   1 
ATOM   2296 H  H    . ALA A 1 122 ? 7.96500   -31.86700 -11.45600 1.000 29.08474 ? 122 ALA A H    1 
ATOM   2297 H  HA   . ALA A 1 122 ? 8.42500   -30.82300 -13.76600 1.000 32.10996 ? 122 ALA A HA   1 
ATOM   2298 H  HB1  . ALA A 1 122 ? 6.24600   -31.46200 -14.34400 1.000 39.24658 ? 122 ALA A HB1  1 
ATOM   2299 H  HB2  . ALA A 1 122 ? 6.98400   -32.63600 -13.57000 1.000 39.24658 ? 122 ALA A HB2  1 
ATOM   2300 H  HB3  . ALA A 1 122 ? 5.92500   -31.72700 -12.81100 1.000 39.24658 ? 122 ALA A HB3  1 
ATOM   2301 N  N    . TRP A 1 123 ? 6.81400   -28.87400 -11.85700 1.000 23.32466 ? 123 TRP A N    1 
ATOM   2302 C  CA   . TRP A 1 123 ? 6.21900   -27.55100 -11.75200 1.000 22.82508 ? 123 TRP A CA   1 
ATOM   2303 C  C    . TRP A 1 123 ? 7.21900   -26.43800 -11.99300 1.000 21.87618 ? 123 TRP A C    1 
ATOM   2304 O  O    . TRP A 1 123 ? 6.80500   -25.29600 -12.21600 1.000 25.01139 ? 123 TRP A O    1 
ATOM   2305 C  CB   . TRP A 1 123 ? 5.53800   -27.37700 -10.36500 1.000 21.39846 ? 123 TRP A CB   1 
ATOM   2306 C  CG   . TRP A 1 123 ? 4.28500   -28.16400 -10.32200 1.000 22.10529 ? 123 TRP A CG   1 
ATOM   2307 C  CD1  . TRP A 1 123 ? 4.10700   -29.38700 -9.76000  1.000 23.76263 ? 123 TRP A CD1  1 
ATOM   2308 C  CD2  . TRP A 1 123 ? 3.05300   -27.81500 -10.92600 1.000 20.21830 ? 123 TRP A CD2  1 
ATOM   2309 N  NE1  . TRP A 1 123 ? 2.83100   -29.83000 -9.98700  1.000 24.96110 ? 123 TRP A NE1  1 
ATOM   2310 C  CE2  . TRP A 1 123 ? 2.16200   -28.88100 -10.70500 1.000 23.06460 ? 123 TRP A CE2  1 
ATOM   2311 C  CE3  . TRP A 1 123 ? 2.62100   -26.71500 -11.65700 1.000 23.32603 ? 123 TRP A CE3  1 
ATOM   2312 C  CZ2  . TRP A 1 123 ? 0.85600   -28.85000 -11.16500 1.000 27.77594 ? 123 TRP A CZ2  1 
ATOM   2313 C  CZ3  . TRP A 1 123 ? 1.33100   -26.69700 -12.12600 1.000 32.61174 ? 123 TRP A CZ3  1 
ATOM   2314 C  CH2  . TRP A 1 123 ? 0.46900   -27.76000 -11.87900 1.000 29.38149 ? 123 TRP A CH2  1 
ATOM   2315 H  H    . TRP A 1 123 ? 6.90100   -29.28900 -11.10900 1.000 27.99316 ? 123 TRP A H    1 
ATOM   2316 H  HA   . TRP A 1 123 ? 5.53000   -27.46900 -12.43000 1.000 27.39367 ? 123 TRP A HA   1 
ATOM   2317 H  HB2  . TRP A 1 123 ? 6.13100   -27.69500 -9.66700  1.000 25.68172 ? 123 TRP A HB2  1 
ATOM   2318 H  HB3  . TRP A 1 123 ? 5.32500   -26.44200 -10.21900 1.000 25.68172 ? 123 TRP A HB3  1 
ATOM   2319 H  HD1  . TRP A 1 123 ? 4.75700   -29.85600 -9.28800  1.000 28.51872 ? 123 TRP A HD1  1 
ATOM   2320 H  HE1  . TRP A 1 123 ? 2.50600   -30.58100 -9.72300  1.000 29.95689 ? 123 TRP A HE1  1 
ATOM   2321 H  HE3  . TRP A 1 123 ? 3.19500   -26.00300 -11.82500 1.000 27.99480 ? 123 TRP A HE3  1 
ATOM   2322 H  HZ2  . TRP A 1 123 ? 0.26600   -29.54800 -10.99100 1.000 33.33469 ? 123 TRP A HZ2  1 
ATOM   2323 H  HZ3  . TRP A 1 123 ? 1.03000   -25.96500 -12.61500 1.000 39.13765 ? 123 TRP A HZ3  1 
ATOM   2324 H  HH2  . TRP A 1 123 ? -0.39800  -27.72400 -12.21300 1.000 35.26135 ? 123 TRP A HH2  1 
ATOM   2325 N  N    . ILE A 1 124 ? 8.51900   -26.73600 -11.93800 1.000 22.19150 ? 124 ILE A N    1 
ATOM   2326 C  CA   . ILE A 1 124 ? 9.53200   -25.73500 -12.23300 1.000 22.86756 ? 124 ILE A CA   1 
ATOM   2327 C  C    . ILE A 1 124 ? 10.32600  -26.06200 -13.48700 1.000 22.50634 ? 124 ILE A C    1 
ATOM   2328 O  O    . ILE A 1 124 ? 11.25100  -25.30300 -13.82600 1.000 25.81287 ? 124 ILE A O    1 
ATOM   2329 C  CB   . ILE A 1 124 ? 10.44500  -25.46400 -11.02800 1.000 24.97562 ? 124 ILE A CB   1 
ATOM   2330 C  CG1  . ILE A 1 124 ? 11.17800  -26.72000 -10.59000 1.000 30.48712 ? 124 ILE A CG1  1 
ATOM   2331 C  CG2  . ILE A 1 124 ? 9.60500   -24.92600 -9.85000  1.000 28.69295 ? 124 ILE A CG2  1 
ATOM   2332 C  CD1  . ILE A 1 124 ? 12.31800  -26.43000 -9.62800  1.000 41.93226 ? 124 ILE A CD1  1 
ATOM   2333 H  H    . ILE A 1 124 ? 8.83300   -27.50900 -11.73100 1.000 26.63337 ? 124 ILE A H    1 
ATOM   2334 H  HA   . ILE A 1 124 ? 9.08000   -24.89700 -12.41500 1.000 27.44464 ? 124 ILE A HA   1 
ATOM   2335 H  HB   . ILE A 1 124 ? 11.10400  -24.80600 -11.30000 1.000 29.97432 ? 124 ILE A HB   1 
ATOM   2336 H  HG12 . ILE A 1 124 ? 10.55200  -27.31200 -10.14500 1.000 36.58811 ? 124 ILE A HG12 1 
ATOM   2337 H  HG13 . ILE A 1 124 ? 11.54900  -27.15800 -11.37200 1.000 36.58811 ? 124 ILE A HG13 1 
ATOM   2338 H  HG21 . ILE A 1 124 ? 10.20100  -24.66900 -9.12800  1.000 34.43511 ? 124 ILE A HG21 1 
ATOM   2339 H  HG22 . ILE A 1 124 ? 9.09800   -24.15500 -10.14900 1.000 34.43511 ? 124 ILE A HG22 1 
ATOM   2340 H  HG23 . ILE A 1 124 ? 9.00100   -25.62200 -9.54800  1.000 34.43511 ? 124 ILE A HG23 1 
ATOM   2341 H  HD11 . ILE A 1 124 ? 12.80200  -27.25300 -9.45500  1.000 50.32229 ? 124 ILE A HD11 1 
ATOM   2342 H  HD12 . ILE A 1 124 ? 12.91100  -25.77600 -10.03000 1.000 50.32229 ? 124 ILE A HD12 1 
ATOM   2343 H  HD13 . ILE A 1 124 ? 11.95200  -26.08000 -8.80100  1.000 50.32229 ? 124 ILE A HD13 1 
ATOM   2344 N  N    A ARG A 1 125 ? 9.98400   -27.13500 -14.19900 0.370 23.53664 ? 125 ARG A N    1 
ATOM   2345 N  N    B ARG A 1 125 ? 9.96500   -27.11900 -14.20900 0.630 23.17447 ? 125 ARG A N    1 
ATOM   2346 C  CA   A ARG A 1 125 ? 10.71000  -27.50500 -15.40900 0.370 29.32451 ? 125 ARG A CA   1 
ATOM   2347 C  CA   B ARG A 1 125 ? 10.68600  -27.49400 -15.42200 0.630 29.28328 ? 125 ARG A CA   1 
ATOM   2348 C  C    A ARG A 1 125 ? 10.59000  -26.40400 -16.45400 0.370 31.53718 ? 125 ARG A C    1 
ATOM   2349 C  C    B ARG A 1 125 ? 10.59100  -26.37400 -16.44500 0.630 31.52564 ? 125 ARG A C    1 
ATOM   2350 O  O    A ARG A 1 125 ? 9.51200   -25.84700 -16.67800 0.370 31.85576 ? 125 ARG A O    1 
ATOM   2351 O  O    B ARG A 1 125 ? 9.53400   -25.76600 -16.63400 0.630 32.16464 ? 125 ARG A O    1 
ATOM   2352 C  CB   A ARG A 1 125 ? 10.14600  -28.80800 -15.99200 0.370 40.48119 ? 125 ARG A CB   1 
ATOM   2353 C  CB   B ARG A 1 125 ? 10.08000  -28.76600 -16.03100 0.630 40.29034 ? 125 ARG A CB   1 
ATOM   2354 C  CG   A ARG A 1 125 ? 10.83100  -30.09200 -15.51000 0.370 60.38550 ? 125 ARG A CG   1 
ATOM   2355 C  CG   B ARG A 1 125 ? 11.08700  -29.87000 -16.42200 0.630 60.58725 ? 125 ARG A CG   1 
ATOM   2356 C  CD   A ARG A 1 125 ? 10.71900  -31.23700 -16.53700 0.370 70.00361 ? 125 ARG A CD   1 
ATOM   2357 C  CD   B ARG A 1 125 ? 11.12600  -31.03400 -15.41400 0.630 69.06262 ? 125 ARG A CD   1 
ATOM   2358 N  NE   A ARG A 1 125 ? 10.16000  -32.46200 -15.96800 0.370 77.62512 ? 125 ARG A NE   1 
ATOM   2359 N  NE   B ARG A 1 125 ? 10.62300  -32.28800 -15.97100 0.630 79.58213 ? 125 ARG A NE   1 
ATOM   2360 C  CZ   A ARG A 1 125 ? 8.95800   -32.95900 -16.24300 0.370 63.94739 ? 125 ARG A CZ   1 
ATOM   2361 C  CZ   B ARG A 1 125 ? 10.33600  -33.36800 -15.25200 0.630 77.45810 ? 125 ARG A CZ   1 
ATOM   2362 N  NH1  A ARG A 1 125 ? 8.13100   -32.36000 -17.08600 0.370 55.50927 ? 125 ARG A NH1  1 
ATOM   2363 N  NH1  B ARG A 1 125 ? 10.42900  -33.36300 -13.93200 0.630 48.93006 ? 125 ARG A NH1  1 
ATOM   2364 N  NH2  A ARG A 1 125 ? 8.57800   -34.09300 -15.66100 0.370 65.91230 ? 125 ARG A NH2  1 
ATOM   2365 N  NH2  B ARG A 1 125 ? 9.94100   -34.47700 -15.87300 0.630 76.52949 ? 125 ARG A NH2  1 
ATOM   2366 H  H    A ARG A 1 125 ? 9.33500   -27.66400 -14.00200 0.370 28.24753 ? 125 ARG A H    1 
ATOM   2367 H  H    B ARG A 1 125 ? 9.30500   -27.63800 -14.01900 0.630 27.81293 ? 125 ARG A H    1 
ATOM   2368 H  HA   A ARG A 1 125 ? 11.64500  -27.63900 -15.18800 0.370 35.19298 ? 125 ARG A HA   1 
ATOM   2369 H  HA   B ARG A 1 125 ? 11.61500  -27.66100 -15.20100 0.630 35.14351 ? 125 ARG A HA   1 
ATOM   2370 H  HB2  A ARG A 1 125 ? 9.20900   -28.87100 -15.75000 0.370 48.58100 ? 125 ARG A HB2  1 
ATOM   2371 H  HB2  B ARG A 1 125 ? 9.46900   -29.15100 -15.38500 0.630 48.35198 ? 125 ARG A HB2  1 
ATOM   2372 H  HB3  A ARG A 1 125 ? 10.23900  -28.77600 -16.95700 0.370 48.58100 ? 125 ARG A HB3  1 
ATOM   2373 H  HB3  B ARG A 1 125 ? 9.59900   -28.51700 -16.83600 0.630 48.35198 ? 125 ARG A HB3  1 
ATOM   2374 H  HG2  A ARG A 1 125 ? 11.77200  -29.91400 -15.35800 0.370 72.46617 ? 125 ARG A HG2  1 
ATOM   2375 H  HG2  B ARG A 1 125 ? 10.83700  -30.23200 -17.28700 0.630 72.70827 ? 125 ARG A HG2  1 
ATOM   2376 H  HG3  A ARG A 1 125 ? 10.41200  -30.38600 -14.68500 0.370 72.46617 ? 125 ARG A HG3  1 
ATOM   2377 H  HG3  B ARG A 1 125 ? 11.97600  -29.48500 -16.46800 0.630 72.70827 ? 125 ARG A HG3  1 
ATOM   2378 H  HD2  A ARG A 1 125 ? 10.14200  -30.95400 -17.26300 0.370 84.00790 ? 125 ARG A HD2  1 
ATOM   2379 H  HD2  B ARG A 1 125 ? 12.04300  -31.17800 -15.13400 0.630 82.87872 ? 125 ARG A HD2  1 
ATOM   2380 H  HD3  A ARG A 1 125 ? 11.60400  -31.44200 -16.87700 0.370 84.00790 ? 125 ARG A HD3  1 
ATOM   2381 H  HD3  B ARG A 1 125 ? 10.57700  -30.80600 -14.64800 0.630 82.87872 ? 125 ARG A HD3  1 
ATOM   2382 H  HE   A ARG A 1 125 ? 10.64900  -32.89700 -15.41000 0.370 93.15372 ? 125 ARG A HE   1 
ATOM   2383 H  HE   B ARG A 1 125 ? 10.50500  -32.33000 -16.82200 0.630 95.50213 ? 125 ARG A HE   1 
ATOM   2384 H  HH11 A ARG A 1 125 ? 8.36600   -31.62900 -17.47200 0.370 66.61469 ? 125 ARG A HH11 1 
ATOM   2385 H  HH11 B ARG A 1 125 ? 10.68000  -32.65100 -13.52100 0.630 58.71965 ? 125 ARG A HH11 1 
ATOM   2386 H  HH12 A ARG A 1 125 ? 7.35900   -32.70200 -17.24700 0.370 66.61469 ? 125 ARG A HH12 1 
ATOM   2387 H  HH12 B ARG A 1 125 ? 10.23800  -34.07300 -13.48600 0.630 58.71965 ? 125 ARG A HH12 1 
ATOM   2388 H  HH21 A ARG A 1 125 ? 9.10700   -34.49400 -15.11400 0.370 79.09833 ? 125 ARG A HH21 1 
ATOM   2389 H  HH21 B ARG A 1 125 ? 9.87400   -34.49000 -16.73100 0.630 91.83896 ? 125 ARG A HH21 1 
ATOM   2390 H  HH22 A ARG A 1 125 ? 7.80300   -34.42500 -15.83000 0.370 79.09833 ? 125 ARG A HH22 1 
ATOM   2391 H  HH22 B ARG A 1 125 ? 9.75300   -35.18200 -15.41700 0.630 91.83896 ? 125 ARG A HH22 1 
ATOM   2392 N  N    . GLY A 1 126 ? 11.71500  -26.09900 -17.10400 1.000 31.44728 ? 126 GLY A N    1 
ATOM   2393 C  CA   . GLY A 1 126 ? 11.75800  -25.09200 -18.13400 1.000 35.62375 ? 126 GLY A CA   1 
ATOM   2394 C  C    . GLY A 1 126 ? 11.97200  -23.67500 -17.65700 1.000 37.98786 ? 126 GLY A C    1 
ATOM   2395 O  O    . GLY A 1 126 ? 12.21300  -22.79000 -18.48800 1.000 41.98551 ? 126 GLY A O    1 
ATOM   2396 H  H    . GLY A 1 126 ? 12.46800  -26.49000 -16.96500 1.000 37.74031 ? 126 GLY A H    1 
ATOM   2397 H  HA2  . GLY A 1 126 ? 12.48200  -25.30700 -18.74400 1.000 42.75207 ? 126 GLY A HA2  1 
ATOM   2398 H  HA3  . GLY A 1 126 ? 10.91900  -25.11300 -18.62000 1.000 42.75207 ? 126 GLY A HA3  1 
ATOM   2399 N  N    . CYS A 1 127 ? 11.91200  -23.41600 -16.35400 1.000 27.94484 ? 127 CYS A N    1 
ATOM   2400 C  CA   . CYS A 1 127 ? 11.97300  -22.05400 -15.85800 1.000 29.03513 ? 127 CYS A CA   1 
ATOM   2401 C  C    . CYS A 1 127 ? 13.41100  -21.58900 -15.65100 1.000 29.81465 ? 127 CYS A C    1 
ATOM   2402 O  O    . CYS A 1 127 ? 14.26900  -22.35600 -15.20700 1.000 30.32444 ? 127 CYS A O    1 
ATOM   2403 C  CB   . CYS A 1 127 ? 11.25100  -21.94200 -14.50800 1.000 26.01621 ? 127 CYS A CB   1 
ATOM   2404 S  SG   . CYS A 1 127 ? 9.51300   -22.45000 -14.46200 1.000 26.39160 ? 127 CYS A SG   1 
ATOM   2405 H  H    . CYS A 1 127 ? 11.83600  -24.01500 -15.74200 1.000 33.53737 ? 127 CYS A H    1 
ATOM   2406 H  HA   . CYS A 1 127 ? 11.55200  -21.48100 -16.51800 1.000 34.84573 ? 127 CYS A HA   1 
ATOM   2407 H  HB2  . CYS A 1 127 ? 11.72500  -22.49700 -13.86900 1.000 31.22302 ? 127 CYS A HB2  1 
ATOM   2408 H  HB3  . CYS A 1 127 ? 11.28200  -21.01400 -14.22900 1.000 31.22302 ? 127 CYS A HB3  1 
ATOM   2409 N  N    A ARG A 1 128 ? 13.64700  -20.31400 -15.94000 0.510 32.24779 ? 128 ARG A N    1 
ATOM   2410 N  N    B ARG A 1 128 ? 13.66900  -20.32100 -15.94900 0.490 32.29777 ? 128 ARG A N    1 
ATOM   2411 C  CA   A ARG A 1 128 ? 14.92600  -19.66900 -15.66700 0.510 39.16862 ? 128 ARG A CA   1 
ATOM   2412 C  CA   B ARG A 1 128 ? 14.97500  -19.72500 -15.67900 0.490 39.11886 ? 128 ARG A CA   1 
ATOM   2413 C  C    A ARG A 1 128 ? 14.92700  -19.21500 -14.21500 0.510 36.56047 ? 128 ARG A C    1 
ATOM   2414 C  C    B ARG A 1 128 ? 14.97100  -19.20800 -14.24600 0.490 36.54070 ? 128 ARG A C    1 
ATOM   2415 O  O    A ARG A 1 128 ? 14.23900  -18.25100 -13.86300 0.510 45.61983 ? 128 ARG A O    1 
ATOM   2416 O  O    B ARG A 1 128 ? 14.32800  -18.19700 -13.94400 0.490 45.48005 ? 128 ARG A O    1 
ATOM   2417 C  CB   A ARG A 1 128 ? 15.07900  -18.47200 -16.60000 0.510 38.89506 ? 128 ARG A CB   1 
ATOM   2418 C  CB   B ARG A 1 128 ? 15.29100  -18.61600 -16.67900 0.490 36.90411 ? 128 ARG A CB   1 
ATOM   2419 C  CG   A ARG A 1 128 ? 16.44800  -18.30400 -17.21500 0.510 46.81132 ? 128 ARG A CG   1 
ATOM   2420 C  CG   B ARG A 1 128 ? 16.78700  -18.36100 -16.84600 0.490 43.95694 ? 128 ARG A CG   1 
ATOM   2421 C  CD   A ARG A 1 128 ? 16.51300  -17.01700 -18.03200 0.510 36.23756 ? 128 ARG A CD   1 
ATOM   2422 C  CD   B ARG A 1 128 ? 17.07500  -17.24400 -17.84400 0.490 38.77229 ? 128 ARG A CD   1 
ATOM   2423 N  NE   A ARG A 1 128 ? 16.22900  -17.25500 -19.44300 0.510 33.47106 ? 128 ARG A NE   1 
ATOM   2424 N  NE   B ARG A 1 128 ? 18.50600  -17.01200 -18.01600 0.490 39.56732 ? 128 ARG A NE   1 
ATOM   2425 C  CZ   A ARG A 1 128 ? 15.44000  -16.50200 -20.20000 0.510 35.45453 ? 128 ARG A CZ   1 
ATOM   2426 C  CZ   B ARG A 1 128 ? 19.30900  -17.76700 -18.75700 0.490 46.00823 ? 128 ARG A CZ   1 
ATOM   2427 N  NH1  A ARG A 1 128 ? 14.81400  -15.44400 -19.71300 0.510 37.20406 ? 128 ARG A NH1  1 
ATOM   2428 N  NH1  B ARG A 1 128 ? 18.86100  -18.83700 -19.39500 0.490 39.59404 ? 128 ARG A NH1  1 
ATOM   2429 N  NH2  A ARG A 1 128 ? 15.27300  -16.82200 -21.48000 0.510 46.65183 ? 128 ARG A NH2  1 
ATOM   2430 N  NH2  B ARG A 1 128 ? 20.59300  -17.43900 -18.86200 0.490 47.64555 ? 128 ARG A NH2  1 
ATOM   2431 H  H    A ARG A 1 128 ? 13.06900  -19.78900 -16.30200 0.510 38.70092 ? 128 ARG A H    1 
ATOM   2432 H  H    B ARG A 1 128 ? 13.10300  -19.78200 -16.31000 0.490 38.76089 ? 128 ARG A H    1 
ATOM   2433 H  HA   A ARG A 1 128 ? 15.66100  -20.28700 -15.80600 0.510 47.00591 ? 128 ARG A HA   1 
ATOM   2434 H  HA   B ARG A 1 128 ? 15.66600  -20.40000 -15.76500 0.490 46.94620 ? 128 ARG A HA   1 
ATOM   2435 H  HB2  A ARG A 1 128 ? 14.44500  -18.56800 -17.32700 0.510 46.67765 ? 128 ARG A HB2  1 
ATOM   2436 H  HB2  B ARG A 1 128 ? 14.93200  -18.86300 -17.54500 0.490 44.28850 ? 128 ARG A HB2  1 
ATOM   2437 H  HB3  A ARG A 1 128 ? 14.88800  -17.66600 -16.09600 0.510 46.67765 ? 128 ARG A HB3  1 
ATOM   2438 H  HB3  B ARG A 1 128 ? 14.88100  -17.79200 -16.37200 0.490 44.28850 ? 128 ARG A HB3  1 
ATOM   2439 H  HG2  A ARG A 1 128 ? 17.11700  -18.25900 -16.51400 0.510 56.17715 ? 128 ARG A HG2  1 
ATOM   2440 H  HG2  B ARG A 1 128 ? 17.16400  -18.10500 -15.98900 0.490 52.75189 ? 128 ARG A HG2  1 
ATOM   2441 H  HG3  A ARG A 1 128 ? 16.63500  -19.05300 -17.80300 0.510 56.17715 ? 128 ARG A HG3  1 
ATOM   2442 H  HG3  B ARG A 1 128 ? 17.21400  -19.17000 -17.16700 0.490 52.75189 ? 128 ARG A HG3  1 
ATOM   2443 H  HD2  A ARG A 1 128 ? 15.85700  -16.38900 -17.69200 0.510 43.48864 ? 128 ARG A HD2  1 
ATOM   2444 H  HD2  B ARG A 1 128 ? 16.70200  -17.48400 -18.70700 0.490 46.53032 ? 128 ARG A HD2  1 
ATOM   2445 H  HD3  A ARG A 1 128 ? 17.40300  -16.63800 -17.96200 0.510 43.48864 ? 128 ARG A HD3  1 
ATOM   2446 H  HD3  B ARG A 1 128 ? 16.67200  -16.42100 -17.52600 0.490 46.53032 ? 128 ARG A HD3  1 
ATOM   2447 H  HE   A ARG A 1 128 ? 16.60100  -17.93600 -19.81300 0.510 40.16884 ? 128 ARG A HE   1 
ATOM   2448 H  HE   B ARG A 1 128 ? 18.85400  -16.34000 -17.60800 0.490 47.48436 ? 128 ARG A HE   1 
ATOM   2449 H  HH11 A ARG A 1 128 ? 14.91300  -15.22800 -18.88700 0.510 44.64844 ? 128 ARG A HH11 1 
ATOM   2450 H  HH11 B ARG A 1 128 ? 18.03200  -19.05800 -19.33500 0.490 47.51642 ? 128 ARG A HH11 1 
ATOM   2451 H  HH12 A ARG A 1 128 ? 14.30800  -14.97100 -20.22300 0.510 44.64844 ? 128 ARG A HH12 1 
ATOM   2452 H  HH12 B ARG A 1 128 ? 19.39900  -19.31100 -19.87000 0.490 47.51642 ? 128 ARG A HH12 1 
ATOM   2453 H  HH21 A ARG A 1 128 ? 15.67400  -17.50900 -21.80700 0.510 55.98577 ? 128 ARG A HH21 1 
ATOM   2454 H  HH21 B ARG A 1 128 ? 20.89500  -16.74500 -18.45200 0.490 57.17823 ? 128 ARG A HH21 1 
ATOM   2455 H  HH22 A ARG A 1 128 ? 14.76500  -16.34300 -21.98100 0.510 55.98577 ? 128 ARG A HH22 1 
ATOM   2456 H  HH22 B ARG A 1 128 ? 21.12300  -17.92000 -19.33900 0.490 57.17823 ? 128 ARG A HH22 1 
ATOM   2457 N  N    . LEU A 1 129 ? 15.68700  -19.90400 -13.37000 1.000 41.15684 ? 129 LEU A N    1 
ATOM   2458 C  CA   . LEU A 1 129 ? 15.70900  -19.57600 -11.94300 1.000 48.03932 ? 129 LEU A CA   1 
ATOM   2459 C  C    . LEU A 1 129 ? 17.12400  -19.36100 -11.41800 1.000 71.59084 ? 129 LEU A C    1 
ATOM   2460 O  O    . LEU A 1 129 ? 17.35400  -18.50500 -10.56100 1.000 69.40991 ? 129 LEU A O    1 
ATOM   2461 C  CB   . LEU A 1 129 ? 15.04800  -20.68500 -11.12200 1.000 47.87896 ? 129 LEU A CB   1 
ATOM   2462 C  CG   . LEU A 1 129 ? 13.60000  -21.02500 -11.47200 1.000 49.22827 ? 129 LEU A CG   1 
ATOM   2463 C  CD1  . LEU A 1 129 ? 13.18700  -22.32100 -10.77800 1.000 41.45790 ? 129 LEU A CD1  1 
ATOM   2464 C  CD2  . LEU A 1 129 ? 12.67100  -19.87200 -11.09900 1.000 46.73662 ? 129 LEU A CD2  1 
ATOM   2465 O  OXT  . LEU A 1 129 ? 18.05900  -20.05100 -11.82300 1.000 73.42226 ? 129 LEU A OXT  1 
ATOM   2466 H  H    . LEU A 1 129 ? 16.19500  -20.56100 -13.59300 1.000 49.39178 ? 129 LEU A H    1 
ATOM   2467 H  HA   . LEU A 1 129 ? 15.21400  -18.75000 -11.82800 1.000 57.65075 ? 129 LEU A HA   1 
ATOM   2468 H  HB2  . LEU A 1 129 ? 15.56800  -21.49600 -11.23900 1.000 57.45832 ? 129 LEU A HB2  1 
ATOM   2469 H  HB3  . LEU A 1 129 ? 15.06000  -20.41600 -10.19000 1.000 57.45832 ? 129 LEU A HB3  1 
ATOM   2470 H  HG   . LEU A 1 129 ? 13.52000  -21.16000 -12.42900 1.000 59.07749 ? 129 LEU A HG   1 
ATOM   2471 H  HD11 . LEU A 1 129 ? 12.26900  -22.52700 -11.01300 1.000 49.75305 ? 129 LEU A HD11 1 
ATOM   2472 H  HD12 . LEU A 1 129 ? 13.77200  -23.03700 -11.07100 1.000 49.75305 ? 129 LEU A HD12 1 
ATOM   2473 H  HD13 . LEU A 1 129 ? 13.26400  -22.20400 -9.81800  1.000 49.75305 ? 129 LEU A HD13 1 
ATOM   2474 H  HD21 . LEU A 1 129 ? 11.75800  -20.12300 -11.30800 1.000 56.08751 ? 129 LEU A HD21 1 
ATOM   2475 H  HD22 . LEU A 1 129 ? 12.75600  -19.69300 -10.15000 1.000 56.08751 ? 129 LEU A HD22 1 
ATOM   2476 H  HD23 . LEU A 1 129 ? 12.92300  -19.08600 -11.60900 1.000 56.08751 ? 129 LEU A HD23 1 
HETATM 2477 C  C1   . EDO B 2 .   ? -3.25100  -22.77700 5.51600   1.000 38.24277 ? 201 EDO A C1   1 
HETATM 2478 O  O1   . EDO B 2 .   ? -4.12300  -22.03300 6.38000   1.000 31.11192 ? 201 EDO A O1   1 
HETATM 2479 C  C2   . EDO B 2 .   ? -3.60900  -24.24400 5.63600   1.000 45.47133 ? 201 EDO A C2   1 
HETATM 2480 O  O2   . EDO B 2 .   ? -3.69500  -24.60900 7.01800   1.000 71.37047 ? 201 EDO A O2   1 
HETATM 2481 H  H11  . EDO B 2 .   ? -3.36900  -22.44300 4.48300   1.000 45.89489 ? 201 EDO A H11  1 
HETATM 2482 H  H12  . EDO B 2 .   ? -2.21000  -22.61800 5.80300   1.000 45.89489 ? 201 EDO A H12  1 
HETATM 2483 H  HO1  . EDO B 2 .   ? -4.62100  -21.38900 5.85900   1.000 37.33787 ? 201 EDO A HO1  1 
HETATM 2484 H  H21  . EDO B 2 .   ? -4.56500  -24.43200 5.14300   1.000 54.56916 ? 201 EDO A H21  1 
HETATM 2485 H  H22  . EDO B 2 .   ? -2.85000  -24.85100 5.13900   1.000 54.56916 ? 201 EDO A H22  1 
HETATM 2486 H  HO2  . EDO B 2 .   ? -4.02400  -25.51500 7.09200   1.000 85.64813 ? 201 EDO A HO2  1 
HETATM 2487 CL CL   . CL  C 3 .   ? 8.27900   -31.82100 7.32300   1.000 26.53245 ? 202 CL  A CL   1 
HETATM 2488 CL CL   . CL  D 3 .   ? 6.34200   -10.53200 -5.14000  1.000 64.41061 ? 203 CL  A CL   1 
HETATM 2489 NA NA   A NA  E 4 .   ? -7.94600  -14.59300 13.21000  0.500 27.42336 ? 204 NA  A NA   1 
HETATM 2490 NA NA   . NA  F 4 .   ? 11.19000  -29.17400 -6.98400  1.000 29.10039 ? 205 NA  A NA   1 
HETATM 2491 O  O    B HOH G 5 .   ? -4.30500  -23.84200 8.82000   0.980 40.59478 ? 301 HOH A O    1 
HETATM 2492 O  O    . HOH G 5 .   ? -19.057   -16.607   0.783     1.000 35.12604 ? 302 HOH A O    1 
HETATM 2493 O  O    . HOH G 5 .   ? 15.84000  -16.61700 -12.75200 1.000 49.83311 ? 303 HOH A O    1 
HETATM 2494 O  O    . HOH G 5 .   ? -1.56600  -13.92900 -2.13900  1.000 31.44758 ? 304 HOH A O    1 
HETATM 2495 O  O    . HOH G 5 .   ? 4.67100   -11.84400 12.98800  1.000 62.52568 ? 305 HOH A O    1 
HETATM 2496 O  O    . HOH G 5 .   ? -1.69100  -12.18100 17.46300  1.000 53.85054 ? 306 HOH A O    1 
HETATM 2497 O  O    . HOH G 5 .   ? 20.96100  -19.26700 -20.84100 1.000 61.45023 ? 307 HOH A O    1 
HETATM 2498 O  O    . HOH G 5 .   ? -5.41200  -9.33500  15.81400  1.000 52.88832 ? 308 HOH A O    1 
HETATM 2499 O  O    . HOH G 5 .   ? -7.61500  -24.87400 0.92000   1.000 36.25014 ? 309 HOH A O    1 
HETATM 2500 O  O    . HOH G 5 .   ? 6.70900   -28.47700 10.49500  1.000 29.27857 ? 310 HOH A O    1 
HETATM 2501 O  O    . HOH G 5 .   ? 0.22600   -12.18400 -2.25400  1.000 31.60140 ? 311 HOH A O    1 
HETATM 2502 O  O    . HOH G 5 .   ? -1.15900  -18.52800 -14.64500 1.000 36.84636 ? 312 HOH A O    1 
HETATM 2503 O  O    . HOH G 5 .   ? -14.12700 -15.14000 7.76500   1.000 19.63523 ? 313 HOH A O    1 
HETATM 2504 O  O    . HOH G 5 .   ? -11.68200 -13.54800 -3.97700  1.000 20.63462 ? 314 HOH A O    1 
HETATM 2505 O  O    A HOH G 5 .   ? -14.52600 -25.38700 8.19900   0.820 40.48799 ? 315 HOH A O    1 
HETATM 2506 O  O    . HOH G 5 .   ? -12.65200 -25.32800 12.68300  1.000 44.42001 ? 316 HOH A O    1 
HETATM 2507 O  O    . HOH G 5 .   ? -5.73200  -11.08200 -9.49500  1.000 21.56407 ? 317 HOH A O    1 
HETATM 2508 O  O    . HOH G 5 .   ? -9.25800  -24.33400 4.72800   1.000 45.17103 ? 318 HOH A O    1 
HETATM 2509 O  O    . HOH G 5 .   ? -1.84600  -33.88700 -9.10300  1.000 29.90886 ? 319 HOH A O    1 
HETATM 2510 O  O    . HOH G 5 .   ? 4.31600   -9.27000  -7.97700  1.000 45.91032 ? 320 HOH A O    1 
HETATM 2511 O  O    . HOH G 5 .   ? 6.69300   -35.65400 -4.06900  1.000 39.92780 ? 321 HOH A O    1 
HETATM 2512 O  O    . HOH G 5 .   ? -7.748    -4.247    5.456     1.000 40.85240 ? 322 HOH A O    1 
HETATM 2513 O  O    . HOH G 5 .   ? -7.83800  -26.31200 -3.44200  1.000 33.30530 ? 323 HOH A O    1 
HETATM 2514 O  O    . HOH G 5 .   ? -3.51700  -7.50500  -8.32900  1.000 33.84361 ? 324 HOH A O    1 
HETATM 2515 O  O    . HOH G 5 .   ? -5.048    -4.357    2.819     1.000 52.00703 ? 325 HOH A O    1 
HETATM 2516 O  O    . HOH G 5 .   ? -4.16000  -6.24700  -0.34600  1.000 39.33492 ? 326 HOH A O    1 
HETATM 2517 O  O    . HOH G 5 .   ? -6.02100  -23.64400 3.25400   1.000 47.74886 ? 327 HOH A O    1 
HETATM 2518 O  O    A HOH G 5 .   ? -4.892    -38.127   0.485     0.980 53.99194 ? 328 HOH A O    1 
HETATM 2519 O  O    . HOH G 5 .   ? -7.566    -25.267   -7.765    1.000 35.48807 ? 329 HOH A O    1 
HETATM 2520 O  O    . HOH G 5 .   ? 3.17600   -8.59900  0.78500   1.000 32.32867 ? 330 HOH A O    1 
HETATM 2521 O  O    . HOH G 5 .   ? 6.81100   -11.00300 -10.82200 1.000 48.52815 ? 331 HOH A O    1 
HETATM 2522 O  O    . HOH G 5 .   ? -12.87100 -12.87100 18.99750  0.50  45.26141 ? 332 HOH A O    1 
HETATM 2523 O  O    . HOH G 5 .   ? 5.32400   -21.78400 13.77600  1.000 47.18002 ? 333 HOH A O    1 
HETATM 2524 O  O    A HOH G 5 .   ? -10.39400 -23.15900 10.56200  0.640 39.09990 ? 334 HOH A O    1 
HETATM 2525 O  O    B HOH G 5 .   ? -11.41300 -24.31400 9.22100   0.360 33.65135 ? 334 HOH A O    1 
HETATM 2526 O  O    B HOH G 5 .   ? 2.09800   -27.22700 9.35600   0.670 24.63592 ? 335 HOH A O    1 
HETATM 2527 O  O    . HOH G 5 .   ? 14.438    -15.243   -8.239    1.000 47.52052 ? 336 HOH A O    1 
HETATM 2528 O  O    . HOH G 5 .   ? 6.15300   -33.85000 -2.16400  1.000 31.49309 ? 337 HOH A O    1 
HETATM 2529 O  O    . HOH G 5 .   ? 1.41100   -12.45900 -14.69900 1.000 50.07669 ? 338 HOH A O    1 
HETATM 2530 O  O    . HOH G 5 .   ? -9.42100  -22.87500 0.03100   1.000 29.33222 ? 339 HOH A O    1 
HETATM 2531 O  O    B HOH G 5 .   ? 6.83500   -28.92400 -16.88900 1.000 54.72767 ? 340 HOH A O    1 
HETATM 2532 O  O    . HOH G 5 .   ? -8.81100  -23.98500 -3.14500  1.000 40.92089 ? 341 HOH A O    1 
HETATM 2533 O  O    . HOH G 5 .   ? -1.16200  -36.45400 -3.61100  1.000 27.75498 ? 342 HOH A O    1 
HETATM 2534 O  O    . HOH G 5 .   ? 2.63800   -32.61100 -9.47700  1.000 33.88250 ? 343 HOH A O    1 
HETATM 2535 O  O    A HOH G 5 .   ? 14.49700  -31.08500 -1.24300  0.590 46.11622 ? 344 HOH A O    1 
HETATM 2536 O  O    B HOH G 5 .   ? 14.66300  -33.63700 -0.69900  0.410 28.86033 ? 344 HOH A O    1 
HETATM 2537 O  O    . HOH G 5 .   ? -1.76800  -16.61800 0.80500   1.000 19.27867 ? 345 HOH A O    1 
HETATM 2538 O  O    . HOH G 5 .   ? -3.51400  -19.76100 -13.51700 1.000 38.69199 ? 346 HOH A O    1 
HETATM 2539 O  O    . HOH G 5 .   ? 3.21600   -12.15000 7.03100   1.000 38.85159 ? 347 HOH A O    1 
HETATM 2540 O  O    . HOH G 5 .   ? 13.892    -24.796   14.204    1.000 47.56276 ? 348 HOH A O    1 
HETATM 2541 O  O    . HOH G 5 .   ? 14.83000  -24.22500 6.23800   1.000 38.56136 ? 349 HOH A O    1 
HETATM 2542 O  O    . HOH G 5 .   ? -0.50800  -38.32800 3.44100   1.000 44.19769 ? 350 HOH A O    1 
HETATM 2543 O  O    . HOH G 5 .   ? 0.81900   -7.06600  1.75000   1.000 36.87109 ? 351 HOH A O    1 
HETATM 2544 O  O    . HOH G 5 .   ? 14.124    -24.925   -13.918   1.000 43.82779 ? 352 HOH A O    1 
HETATM 2545 O  O    . HOH G 5 .   ? -9.81100  -13.20600 11.89300  1.000 27.15108 ? 353 HOH A O    1 
HETATM 2546 O  O    A HOH G 5 .   ? 13.85700  -17.59000 5.48800   0.530 35.54036 ? 354 HOH A O    1 
HETATM 2547 O  O    B HOH G 5 .   ? 14.66800  -18.71100 3.93900   0.470 37.35153 ? 354 HOH A O    1 
HETATM 2548 O  O    . HOH G 5 .   ? -9.25200  -21.01300 -5.01000  1.000 39.85515 ? 355 HOH A O    1 
HETATM 2549 O  O    . HOH G 5 .   ? 8.90700   -13.03800 -10.55600 1.000 36.94652 ? 356 HOH A O    1 
HETATM 2550 O  O    . HOH G 5 .   ? -5.80600  -26.47100 3.75600   1.000 35.45328 ? 357 HOH A O    1 
HETATM 2551 O  O    . HOH G 5 .   ? 15.27000  -21.93300 2.19800   1.000 47.29198 ? 358 HOH A O    1 
HETATM 2552 O  O    . HOH G 5 .   ? -2.83800  -10.51300 -13.35400 1.000 36.87478 ? 359 HOH A O    1 
HETATM 2553 O  O    . HOH G 5 .   ? -8.45600  -18.03100 -8.27600  1.000 28.38920 ? 360 HOH A O    1 
HETATM 2554 O  O    . HOH G 5 .   ? 8.28800   -16.29600 9.14100   1.000 49.17064 ? 361 HOH A O    1 
HETATM 2555 O  O    . HOH G 5 .   ? -17.42200 -8.25900  11.23500  1.000 41.89945 ? 362 HOH A O    1 
HETATM 2556 O  O    . HOH G 5 .   ? 11.35700  -31.54200 -1.23300  1.000 24.91889 ? 363 HOH A O    1 
HETATM 2557 O  O    A HOH G 5 .   ? 11.54800  -18.61000 -17.14100 0.650 33.79830 ? 364 HOH A O    1 
HETATM 2558 O  O    B HOH G 5 .   ? 11.72000  -17.79900 -14.27800 0.350 30.98065 ? 364 HOH A O    1 
HETATM 2559 O  O    . HOH G 5 .   ? -4.55400  -33.31300 -9.19400  1.000 27.06500 ? 365 HOH A O    1 
HETATM 2560 O  O    . HOH G 5 .   ? 10.67000  -31.82100 4.95000   1.000 27.87935 ? 366 HOH A O    1 
HETATM 2561 O  O    . HOH G 5 .   ? -14.96200 -14.96200 0.00000   0.5   45.15829 ? 367 HOH A O    1 
HETATM 2562 O  O    A HOH G 5 .   ? 3.94000   -37.83800 -10.56300 0.510 32.16147 ? 368 HOH A O    1 
HETATM 2563 O  O    B HOH G 5 .   ? 3.06100   -36.65900 -11.08900 0.490 31.99008 ? 368 HOH A O    1 
HETATM 2564 O  O    A HOH G 5 .   ? 14.85100  -19.88500 -1.92800  0.580 27.68832 ? 369 HOH A O    1 
HETATM 2565 O  O    B HOH G 5 .   ? 14.18800  -26.32100 -4.72900  0.420 23.51614 ? 369 HOH A O    1 
HETATM 2566 O  O    . HOH G 5 .   ? -11.79300 -11.94500 13.80100  1.000 32.33724 ? 370 HOH A O    1 
HETATM 2567 O  O    . HOH G 5 .   ? -10.354   -6.114    12.185    1.000 33.97992 ? 371 HOH A O    1 
HETATM 2568 O  O    . HOH G 5 .   ? 1.01700   -11.29900 0.27900   1.000 28.98362 ? 372 HOH A O    1 
HETATM 2569 O  O    A HOH G 5 .   ? -2.56600  -7.38700  13.35300  0.520 38.56159 ? 373 HOH A O    1 
HETATM 2570 O  O    B HOH G 5 .   ? -3.42400  -7.69200  12.66500  0.480 40.46308 ? 373 HOH A O    1 
HETATM 2571 O  O    A HOH G 5 .   ? -2.92800  -14.40800 18.21700  0.760 55.71462 ? 374 HOH A O    1 
HETATM 2572 O  O    . HOH G 5 .   ? 5.49800   -19.79900 -16.90600 1.000 35.01258 ? 375 HOH A O    1 
HETATM 2573 O  O    . HOH G 5 .   ? -19.086   -10.291   6.379     1.000 30.96233 ? 376 HOH A O    1 
HETATM 2574 O  O    . HOH G 5 .   ? 5.32900   -9.93500  6.21100   1.000 52.97365 ? 377 HOH A O    1 
HETATM 2575 O  O    . HOH G 5 .   ? 17.46800  -22.25200 -14.13500 1.000 54.40417 ? 378 HOH A O    1 
HETATM 2576 O  O    . HOH G 5 .   ? -1.76300  -5.34600  -4.70400  1.000 35.64190 ? 379 HOH A O    1 
HETATM 2577 O  O    . HOH G 5 .   ? -13.721   -7.619    14.796    1.000 55.24395 ? 380 HOH A O    1 
HETATM 2578 O  O    A HOH G 5 .   ? -7.83700  -12.73000 14.42100  0.500 31.46814 ? 381 HOH A O    1 
HETATM 2579 O  O    B HOH G 5 .   ? 3.86700   -13.05000 9.22400   0.800 37.49839 ? 382 HOH A O    1 
HETATM 2580 O  O    . HOH G 5 .   ? 5.83500   -17.46800 -16.15200 1.000 31.16858 ? 383 HOH A O    1 
HETATM 2581 O  O    . HOH G 5 .   ? -7.20900  -23.94700 5.89100   1.000 50.00623 ? 384 HOH A O    1 
HETATM 2582 O  O    . HOH G 5 .   ? 9.57200   -33.29100 -3.14300  1.000 38.60416 ? 385 HOH A O    1 
HETATM 2583 O  O    . HOH G 5 .   ? -1.99500  -24.32800 14.59700  1.000 63.52452 ? 386 HOH A O    1 
HETATM 2584 O  O    . HOH G 5 .   ? 3.55300   -22.57100 -18.10400 1.000 49.11013 ? 387 HOH A O    1 
HETATM 2585 O  O    A HOH G 5 .   ? -4.49000  -7.68200  -10.28600 0.580 40.04929 ? 388 HOH A O    1 
HETATM 2586 O  O    B HOH G 5 .   ? -6.21400  -7.44900  -10.92900 0.420 30.65011 ? 388 HOH A O    1 
HETATM 2587 O  O    . HOH G 5 .   ? 10.15400  -29.79200 8.40700   1.000 51.28723 ? 389 HOH A O    1 
HETATM 2588 O  O    . HOH G 5 .   ? 9.92900   -34.69500 -7.26200  1.000 56.84557 ? 390 HOH A O    1 
HETATM 2589 O  O    . HOH G 5 .   ? 11.23100  -12.62400 2.52100   1.000 61.10835 ? 391 HOH A O    1 
HETATM 2590 O  O    . HOH G 5 .   ? 10.83100  -10.32300 4.07900   1.000 63.86184 ? 392 HOH A O    1 
HETATM 2591 O  O    A HOH G 5 .   ? 17.89800  -20.20600 -2.34400  1.000 49.55894 ? 393 HOH A O    1 
HETATM 2592 O  O    B HOH G 5 .   ? 9.59800   -11.01800 -6.07300  0.760 45.18304 ? 394 HOH A O    1 
HETATM 2593 O  O    . HOH G 5 .   ? -0.14900  -24.04700 -14.94600 1.000 50.03330 ? 395 HOH A O    1 
HETATM 2594 O  O    A HOH G 5 .   ? 2.00800   -19.69700 -17.27000 0.520 40.69407 ? 396 HOH A O    1 
HETATM 2595 O  O    B HOH G 5 .   ? 1.23200   -20.71100 -15.81700 0.480 32.95468 ? 396 HOH A O    1 
HETATM 2596 O  O    A HOH G 5 .   ? 12.04400  -12.68000 -8.68800  0.520 35.03196 ? 397 HOH A O    1 
HETATM 2597 O  O    B HOH G 5 .   ? 10.42300  -11.81600 -8.45000  0.480 30.58380 ? 397 HOH A O    1 
HETATM 2598 O  O    . HOH G 5 .   ? -5.06800  -6.53800  11.87100  1.000 52.13399 ? 398 HOH A O    1 
HETATM 2599 O  O    A HOH G 5 .   ? 3.36500   -28.52200 -14.88900 0.270 36.09703 ? 399 HOH A O    1 
HETATM 2600 O  O    B HOH G 5 .   ? 2.67300   -29.35300 -14.83500 0.730 41.57296 ? 399 HOH A O    1 
HETATM 2601 O  O    A HOH G 5 .   ? 8.21500   -38.66500 -7.70100  0.650 47.89699 ? 400 HOH A O    1 
HETATM 2602 O  O    B HOH G 5 .   ? 9.40500   -37.00800 -7.19000  0.350 38.07825 ? 400 HOH A O    1 
HETATM 2603 O  O    . HOH G 5 .   ? -9.94600  -19.62200 -10.54000 1.000 56.54807 ? 401 HOH A O    1 
HETATM 2604 O  O    . HOH G 5 .   ? -3.99900  -25.95400 13.10800  1.000 57.60177 ? 402 HOH A O    1 
HETATM 2605 O  O    . HOH G 5 .   ? 4.11400   -27.89200 -16.59000 1.000 59.01352 ? 403 HOH A O    1 
HETATM 2606 O  O    . HOH G 5 .   ? -2.78800  -4.63800  -6.97000  1.000 65.75853 ? 404 HOH A O    1 
HETATM 2607 O  O    . HOH G 5 .   ? -14.33200 -11.39700 16.12600  1.000 57.73035 ? 405 HOH A O    1 
HETATM 2608 O  O    . HOH G 5 .   ? 13.97400  -27.51400 -7.17200  1.000 50.80865 ? 406 HOH A O    1 
HETATM 2609 O  O    . HOH G 5 .   ? 1.310     -15.000   -17.459   1.000 60.82145 ? 407 HOH A O    1 
HETATM 2610 O  O    B HOH G 5 .   ? -0.25000  -26.36300 10.75200  0.890 39.97375 ? 408 HOH A O    1 
HETATM 2611 O  O    . HOH G 5 .   ? 0.44500   -39.49200 0.27800   1.000 52.18431 ? 409 HOH A O    1 
HETATM 2612 O  O    . HOH G 5 .   ? 15.79400  -20.15700 5.63200   1.000 60.78195 ? 410 HOH A O    1 
# 
