data_9FA0
# 
_entry.id   9FA0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9FA0         pdb_00009fa0 10.2210/pdb9fa0/pdb 
WWPDB D_1292137689 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9FA0 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gil2@mail.huji.ac.il 
_pdbx_contact_author.name_first         Gil 
_pdbx_contact_author.name_last          shoham 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2491-3715 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hadad, N.'    1 ? 
'Shulami, S.'  2 ? 
'Pomyalov, S.' 3 ? 
'Lansky, S.'   4 ? 
'Lavid, N.'    5 ? 
'Shoham, Y.'   6 ? 
'Shoham, G.'   7 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'The structure of ScoC, a global regulator protein from Geobacillus kaustophilus' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hadad, N.'    1 ? 
primary 'Shulami, S.'  2 ? 
primary 'Pomyalov, S.' 3 ? 
primary 'Lansky, S.'   4 ? 
primary 'Lavid, N.'    5 ? 
primary 'Shoham, Y.'   6 ? 
primary 'Shoham, G.'   7 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           ScoC 
_entity.formula_weight             24585.248 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKATEQHYSIKEAMLFSQRIAQLSKALWKSIEKDWQRWIKPFDLNINEHHILWIAYHFKGASISEIAKFGVMHVSTAFNF
SKKLEEKGLLSFSKKQDDKRNTYIELTEKGEEVLMKLMETYDPTKNAVFNGALPLRELYGKFPEILEMMCIVRNIYGDDF
MEIFERAFENIKEDFIEQDGKLVKRKPKTEEHEKELASQANHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKATEQHYSIKEAMLFSQRIAQLSKALWKSIEKDWQRWIKPFDLNINEHHILWIAYHFKGASISEIAKFGVMHVSTAFNF
SKKLEEKGLLSFSKKQDDKRNTYIELTEKGEEVLMKLMETYDPTKNAVFNGALPLRELYGKFPEILEMMCIVRNIYGDDF
MEIFERAFENIKEDFIEQDGKLVKRKPKTEEHEKELASQANHHHHHH
;
_entity_poly.pdbx_strand_id                 B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   ALA n 
1 4   THR n 
1 5   GLU n 
1 6   GLN n 
1 7   HIS n 
1 8   TYR n 
1 9   SER n 
1 10  ILE n 
1 11  LYS n 
1 12  GLU n 
1 13  ALA n 
1 14  MET n 
1 15  LEU n 
1 16  PHE n 
1 17  SER n 
1 18  GLN n 
1 19  ARG n 
1 20  ILE n 
1 21  ALA n 
1 22  GLN n 
1 23  LEU n 
1 24  SER n 
1 25  LYS n 
1 26  ALA n 
1 27  LEU n 
1 28  TRP n 
1 29  LYS n 
1 30  SER n 
1 31  ILE n 
1 32  GLU n 
1 33  LYS n 
1 34  ASP n 
1 35  TRP n 
1 36  GLN n 
1 37  ARG n 
1 38  TRP n 
1 39  ILE n 
1 40  LYS n 
1 41  PRO n 
1 42  PHE n 
1 43  ASP n 
1 44  LEU n 
1 45  ASN n 
1 46  ILE n 
1 47  ASN n 
1 48  GLU n 
1 49  HIS n 
1 50  HIS n 
1 51  ILE n 
1 52  LEU n 
1 53  TRP n 
1 54  ILE n 
1 55  ALA n 
1 56  TYR n 
1 57  HIS n 
1 58  PHE n 
1 59  LYS n 
1 60  GLY n 
1 61  ALA n 
1 62  SER n 
1 63  ILE n 
1 64  SER n 
1 65  GLU n 
1 66  ILE n 
1 67  ALA n 
1 68  LYS n 
1 69  PHE n 
1 70  GLY n 
1 71  VAL n 
1 72  MET n 
1 73  HIS n 
1 74  VAL n 
1 75  SER n 
1 76  THR n 
1 77  ALA n 
1 78  PHE n 
1 79  ASN n 
1 80  PHE n 
1 81  SER n 
1 82  LYS n 
1 83  LYS n 
1 84  LEU n 
1 85  GLU n 
1 86  GLU n 
1 87  LYS n 
1 88  GLY n 
1 89  LEU n 
1 90  LEU n 
1 91  SER n 
1 92  PHE n 
1 93  SER n 
1 94  LYS n 
1 95  LYS n 
1 96  GLN n 
1 97  ASP n 
1 98  ASP n 
1 99  LYS n 
1 100 ARG n 
1 101 ASN n 
1 102 THR n 
1 103 TYR n 
1 104 ILE n 
1 105 GLU n 
1 106 LEU n 
1 107 THR n 
1 108 GLU n 
1 109 LYS n 
1 110 GLY n 
1 111 GLU n 
1 112 GLU n 
1 113 VAL n 
1 114 LEU n 
1 115 MET n 
1 116 LYS n 
1 117 LEU n 
1 118 MET n 
1 119 GLU n 
1 120 THR n 
1 121 TYR n 
1 122 ASP n 
1 123 PRO n 
1 124 THR n 
1 125 LYS n 
1 126 ASN n 
1 127 ALA n 
1 128 VAL n 
1 129 PHE n 
1 130 ASN n 
1 131 GLY n 
1 132 ALA n 
1 133 LEU n 
1 134 PRO n 
1 135 LEU n 
1 136 ARG n 
1 137 GLU n 
1 138 LEU n 
1 139 TYR n 
1 140 GLY n 
1 141 LYS n 
1 142 PHE n 
1 143 PRO n 
1 144 GLU n 
1 145 ILE n 
1 146 LEU n 
1 147 GLU n 
1 148 MET n 
1 149 MET n 
1 150 CYS n 
1 151 ILE n 
1 152 VAL n 
1 153 ARG n 
1 154 ASN n 
1 155 ILE n 
1 156 TYR n 
1 157 GLY n 
1 158 ASP n 
1 159 ASP n 
1 160 PHE n 
1 161 MET n 
1 162 GLU n 
1 163 ILE n 
1 164 PHE n 
1 165 GLU n 
1 166 ARG n 
1 167 ALA n 
1 168 PHE n 
1 169 GLU n 
1 170 ASN n 
1 171 ILE n 
1 172 LYS n 
1 173 GLU n 
1 174 ASP n 
1 175 PHE n 
1 176 ILE n 
1 177 GLU n 
1 178 GLN n 
1 179 ASP n 
1 180 GLY n 
1 181 LYS n 
1 182 LEU n 
1 183 VAL n 
1 184 LYS n 
1 185 ARG n 
1 186 LYS n 
1 187 PRO n 
1 188 LYS n 
1 189 THR n 
1 190 GLU n 
1 191 GLU n 
1 192 HIS n 
1 193 GLU n 
1 194 LYS n 
1 195 GLU n 
1 196 LEU n 
1 197 ALA n 
1 198 SER n 
1 199 GLN n 
1 200 ALA n 
1 201 ASN n 
1 202 HIS n 
1 203 HIS n 
1 204 HIS n 
1 205 HIS n 
1 206 HIS n 
1 207 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   207 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Geobacillus kaustophilus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1462 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   B . n 
A 1 2   LYS 2   2   ?   ?   ?   B . n 
A 1 3   ALA 3   3   ?   ?   ?   B . n 
A 1 4   THR 4   4   ?   ?   ?   B . n 
A 1 5   GLU 5   5   ?   ?   ?   B . n 
A 1 6   GLN 6   6   6   GLN GLN B . n 
A 1 7   HIS 7   7   7   HIS HIS B . n 
A 1 8   TYR 8   8   8   TYR TYR B . n 
A 1 9   SER 9   9   9   SER SER B . n 
A 1 10  ILE 10  10  10  ILE ILE B . n 
A 1 11  LYS 11  11  11  LYS LYS B . n 
A 1 12  GLU 12  12  12  GLU GLU B . n 
A 1 13  ALA 13  13  13  ALA ALA B . n 
A 1 14  MET 14  14  14  MET MET B . n 
A 1 15  LEU 15  15  15  LEU LEU B . n 
A 1 16  PHE 16  16  16  PHE PHE B . n 
A 1 17  SER 17  17  17  SER SER B . n 
A 1 18  GLN 18  18  18  GLN GLN B . n 
A 1 19  ARG 19  19  19  ARG ARG B . n 
A 1 20  ILE 20  20  20  ILE ILE B . n 
A 1 21  ALA 21  21  21  ALA ALA B . n 
A 1 22  GLN 22  22  22  GLN GLN B . n 
A 1 23  LEU 23  23  23  LEU LEU B . n 
A 1 24  SER 24  24  24  SER SER B . n 
A 1 25  LYS 25  25  25  LYS LYS B . n 
A 1 26  ALA 26  26  26  ALA ALA B . n 
A 1 27  LEU 27  27  27  LEU LEU B . n 
A 1 28  TRP 28  28  28  TRP TRP B . n 
A 1 29  LYS 29  29  29  LYS LYS B . n 
A 1 30  SER 30  30  30  SER SER B . n 
A 1 31  ILE 31  31  31  ILE ILE B . n 
A 1 32  GLU 32  32  32  GLU GLU B . n 
A 1 33  LYS 33  33  33  LYS LYS B . n 
A 1 34  ASP 34  34  34  ASP ASP B . n 
A 1 35  TRP 35  35  35  TRP TRP B . n 
A 1 36  GLN 36  36  36  GLN GLN B . n 
A 1 37  ARG 37  37  37  ARG ARG B . n 
A 1 38  TRP 38  38  38  TRP TRP B . n 
A 1 39  ILE 39  39  39  ILE ILE B . n 
A 1 40  LYS 40  40  40  LYS LYS B . n 
A 1 41  PRO 41  41  41  PRO PRO B . n 
A 1 42  PHE 42  42  42  PHE PHE B . n 
A 1 43  ASP 43  43  43  ASP ASP B . n 
A 1 44  LEU 44  44  44  LEU LEU B . n 
A 1 45  ASN 45  45  45  ASN ASN B . n 
A 1 46  ILE 46  46  46  ILE ILE B . n 
A 1 47  ASN 47  47  47  ASN ASN B . n 
A 1 48  GLU 48  48  48  GLU GLU B . n 
A 1 49  HIS 49  49  49  HIS HIS B . n 
A 1 50  HIS 50  50  50  HIS HIS B . n 
A 1 51  ILE 51  51  51  ILE ILE B . n 
A 1 52  LEU 52  52  52  LEU LEU B . n 
A 1 53  TRP 53  53  53  TRP TRP B . n 
A 1 54  ILE 54  54  54  ILE ILE B . n 
A 1 55  ALA 55  55  55  ALA ALA B . n 
A 1 56  TYR 56  56  56  TYR TYR B . n 
A 1 57  HIS 57  57  57  HIS HIS B . n 
A 1 58  PHE 58  58  58  PHE PHE B . n 
A 1 59  LYS 59  59  59  LYS LYS B . n 
A 1 60  GLY 60  60  60  GLY GLY B . n 
A 1 61  ALA 61  61  61  ALA ALA B . n 
A 1 62  SER 62  62  62  SER SER B . n 
A 1 63  ILE 63  63  63  ILE ILE B . n 
A 1 64  SER 64  64  64  SER SER B . n 
A 1 65  GLU 65  65  65  GLU GLU B . n 
A 1 66  ILE 66  66  66  ILE ILE B . n 
A 1 67  ALA 67  67  67  ALA ALA B . n 
A 1 68  LYS 68  68  68  LYS LYS B . n 
A 1 69  PHE 69  69  69  PHE PHE B . n 
A 1 70  GLY 70  70  70  GLY GLY B . n 
A 1 71  VAL 71  71  71  VAL VAL B . n 
A 1 72  MET 72  72  72  MET MET B . n 
A 1 73  HIS 73  73  73  HIS HIS B . n 
A 1 74  VAL 74  74  74  VAL VAL B . n 
A 1 75  SER 75  75  75  SER SER B . n 
A 1 76  THR 76  76  76  THR THR B . n 
A 1 77  ALA 77  77  77  ALA ALA B . n 
A 1 78  PHE 78  78  78  PHE PHE B . n 
A 1 79  ASN 79  79  79  ASN ASN B . n 
A 1 80  PHE 80  80  80  PHE PHE B . n 
A 1 81  SER 81  81  81  SER SER B . n 
A 1 82  LYS 82  82  82  LYS LYS B . n 
A 1 83  LYS 83  83  83  LYS LYS B . n 
A 1 84  LEU 84  84  84  LEU LEU B . n 
A 1 85  GLU 85  85  85  GLU GLU B . n 
A 1 86  GLU 86  86  86  GLU GLU B . n 
A 1 87  LYS 87  87  87  LYS LYS B . n 
A 1 88  GLY 88  88  88  GLY GLY B . n 
A 1 89  LEU 89  89  89  LEU LEU B . n 
A 1 90  LEU 90  90  90  LEU LEU B . n 
A 1 91  SER 91  91  91  SER SER B . n 
A 1 92  PHE 92  92  92  PHE PHE B . n 
A 1 93  SER 93  93  93  SER SER B . n 
A 1 94  LYS 94  94  94  LYS LYS B . n 
A 1 95  LYS 95  95  95  LYS LYS B . n 
A 1 96  GLN 96  96  96  GLN GLN B . n 
A 1 97  ASP 97  97  97  ASP ASP B . n 
A 1 98  ASP 98  98  98  ASP ASP B . n 
A 1 99  LYS 99  99  99  LYS LYS B . n 
A 1 100 ARG 100 100 100 ARG ARG B . n 
A 1 101 ASN 101 101 101 ASN ASN B . n 
A 1 102 THR 102 102 102 THR THR B . n 
A 1 103 TYR 103 103 103 TYR TYR B . n 
A 1 104 ILE 104 104 104 ILE ILE B . n 
A 1 105 GLU 105 105 105 GLU GLU B . n 
A 1 106 LEU 106 106 106 LEU LEU B . n 
A 1 107 THR 107 107 107 THR THR B . n 
A 1 108 GLU 108 108 108 GLU GLU B . n 
A 1 109 LYS 109 109 109 LYS LYS B . n 
A 1 110 GLY 110 110 110 GLY GLY B . n 
A 1 111 GLU 111 111 111 GLU GLU B . n 
A 1 112 GLU 112 112 112 GLU GLU B . n 
A 1 113 VAL 113 113 113 VAL VAL B . n 
A 1 114 LEU 114 114 114 LEU LEU B . n 
A 1 115 MET 115 115 115 MET MET B . n 
A 1 116 LYS 116 116 116 LYS LYS B . n 
A 1 117 LEU 117 117 117 LEU LEU B . n 
A 1 118 MET 118 118 118 MET MET B . n 
A 1 119 GLU 119 119 119 GLU GLU B . n 
A 1 120 THR 120 120 120 THR THR B . n 
A 1 121 TYR 121 121 121 TYR TYR B . n 
A 1 122 ASP 122 122 122 ASP ASP B . n 
A 1 123 PRO 123 123 123 PRO PRO B . n 
A 1 124 THR 124 124 124 THR THR B . n 
A 1 125 LYS 125 125 125 LYS LYS B . n 
A 1 126 ASN 126 126 126 ASN ASN B . n 
A 1 127 ALA 127 127 127 ALA ALA B . n 
A 1 128 VAL 128 128 128 VAL VAL B . n 
A 1 129 PHE 129 129 129 PHE PHE B . n 
A 1 130 ASN 130 130 130 ASN ASN B . n 
A 1 131 GLY 131 131 131 GLY GLY B . n 
A 1 132 ALA 132 132 132 ALA ALA B . n 
A 1 133 LEU 133 133 133 LEU LEU B . n 
A 1 134 PRO 134 134 134 PRO PRO B . n 
A 1 135 LEU 135 135 135 LEU LEU B . n 
A 1 136 ARG 136 136 136 ARG ARG B . n 
A 1 137 GLU 137 137 137 GLU GLU B . n 
A 1 138 LEU 138 138 138 LEU LEU B . n 
A 1 139 TYR 139 139 139 TYR TYR B . n 
A 1 140 GLY 140 140 140 GLY GLY B . n 
A 1 141 LYS 141 141 141 LYS LYS B . n 
A 1 142 PHE 142 142 142 PHE PHE B . n 
A 1 143 PRO 143 143 143 PRO PRO B . n 
A 1 144 GLU 144 144 144 GLU GLU B . n 
A 1 145 ILE 145 145 145 ILE ILE B . n 
A 1 146 LEU 146 146 146 LEU LEU B . n 
A 1 147 GLU 147 147 147 GLU GLU B . n 
A 1 148 MET 148 148 148 MET MET B . n 
A 1 149 MET 149 149 149 MET MET B . n 
A 1 150 CYS 150 150 150 CYS CYS B . n 
A 1 151 ILE 151 151 151 ILE ILE B . n 
A 1 152 VAL 152 152 152 VAL VAL B . n 
A 1 153 ARG 153 153 153 ARG ARG B . n 
A 1 154 ASN 154 154 154 ASN ASN B . n 
A 1 155 ILE 155 155 155 ILE ILE B . n 
A 1 156 TYR 156 156 156 TYR TYR B . n 
A 1 157 GLY 157 157 157 GLY GLY B . n 
A 1 158 ASP 158 158 158 ASP ASP B . n 
A 1 159 ASP 159 159 159 ASP ASP B . n 
A 1 160 PHE 160 160 160 PHE PHE B . n 
A 1 161 MET 161 161 161 MET MET B . n 
A 1 162 GLU 162 162 162 GLU GLU B . n 
A 1 163 ILE 163 163 163 ILE ILE B . n 
A 1 164 PHE 164 164 164 PHE PHE B . n 
A 1 165 GLU 165 165 165 GLU GLU B . n 
A 1 166 ARG 166 166 166 ARG ARG B . n 
A 1 167 ALA 167 167 167 ALA ALA B . n 
A 1 168 PHE 168 168 168 PHE PHE B . n 
A 1 169 GLU 169 169 169 GLU GLU B . n 
A 1 170 ASN 170 170 170 ASN ASN B . n 
A 1 171 ILE 171 171 171 ILE ILE B . n 
A 1 172 LYS 172 172 172 LYS LYS B . n 
A 1 173 GLU 173 173 173 GLU GLU B . n 
A 1 174 ASP 174 174 174 ASP ASP B . n 
A 1 175 PHE 175 175 175 PHE PHE B . n 
A 1 176 ILE 176 176 176 ILE ILE B . n 
A 1 177 GLU 177 177 177 GLU GLU B . n 
A 1 178 GLN 178 178 178 GLN GLN B . n 
A 1 179 ASP 179 179 179 ASP ASP B . n 
A 1 180 GLY 180 180 180 GLY GLY B . n 
A 1 181 LYS 181 181 181 LYS LYS B . n 
A 1 182 LEU 182 182 182 LEU LEU B . n 
A 1 183 VAL 183 183 ?   ?   ?   B . n 
A 1 184 LYS 184 184 ?   ?   ?   B . n 
A 1 185 ARG 185 185 ?   ?   ?   B . n 
A 1 186 LYS 186 186 ?   ?   ?   B . n 
A 1 187 PRO 187 187 ?   ?   ?   B . n 
A 1 188 LYS 188 188 ?   ?   ?   B . n 
A 1 189 THR 189 189 ?   ?   ?   B . n 
A 1 190 GLU 190 190 ?   ?   ?   B . n 
A 1 191 GLU 191 191 ?   ?   ?   B . n 
A 1 192 HIS 192 192 ?   ?   ?   B . n 
A 1 193 GLU 193 193 ?   ?   ?   B . n 
A 1 194 LYS 194 194 ?   ?   ?   B . n 
A 1 195 GLU 195 195 ?   ?   ?   B . n 
A 1 196 LEU 196 196 ?   ?   ?   B . n 
A 1 197 ALA 197 197 ?   ?   ?   B . n 
A 1 198 SER 198 198 ?   ?   ?   B . n 
A 1 199 GLN 199 199 ?   ?   ?   B . n 
A 1 200 ALA 200 200 ?   ?   ?   B . n 
A 1 201 ASN 201 201 ?   ?   ?   B . n 
A 1 202 HIS 202 202 ?   ?   ?   B . n 
A 1 203 HIS 203 203 ?   ?   ?   B . n 
A 1 204 HIS 204 204 ?   ?   ?   B . n 
A 1 205 HIS 205 205 ?   ?   ?   B . n 
A 1 206 HIS 206 206 ?   ?   ?   B . n 
A 1 207 HIS 207 207 ?   ?   ?   B . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.17.1_3660 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9FA0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     95.182 
_cell.length_a_esd                 ? 
_cell.length_b                     95.182 
_cell.length_b_esd                 ? 
_cell.length_c                     156.018 
_cell.length_c_esd                 ? 
_cell.volume                       1413462.720 
_cell.volume_esd                   ? 
_cell.Z_PDB                        16 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9FA0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                98 
_symmetry.space_group_name_Hall            'I 4bw 2bw' 
_symmetry.space_group_name_H-M             'I 41 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9FA0 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.59 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50 
_exptl_crystal.description                  Diamonds 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20% PEG 3350 and 8% Tacsimate pH 4' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2017-12-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    M 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.96 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.96 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          112.84 
_reflns.entry_id                                       9FA0 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.15 
_reflns.d_resolution_low                               47.59 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     6497 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          24.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.07 
_reflns.pdbx_Rpim_I_all                                0.02 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.0 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.069 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.15 
_reflns_shell.d_res_low                                     3.26 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1143 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.96 
_reflns_shell.pdbx_Rpim_I_all                               0.25 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.84 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.92 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               97.79 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9FA0 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.15 
_refine.ls_d_res_low                             47.59 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     6481 
_refine.ls_number_reflns_R_free                  329 
_refine.ls_number_reflns_R_work                  6153 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.54 
_refine.ls_percent_reflns_R_free                 5.08 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2349 
_refine.ls_R_factor_R_free                       0.2500 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2341 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.6918 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3484 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.15 
_refine_hist.d_res_low                        47.59 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               1477 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1477 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0127  ? 1512 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2908  ? 2028 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0615  ? 211  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0076  ? 256  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 19.4679 ? 188  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.15 3.97  . . 157 3025 99.94 . . . . 0.2588 . . . . . . . . . . . 0.2774 
'X-RAY DIFFRACTION' 3.97 47.59 . . 172 3128 99.16 . . . . 0.2266 . . . . . . . . . . . 0.2430 
# 
_struct.entry_id                     9FA0 
_struct.title                        'The structure of ScoC, a global regulator protein from Geobacillus kaustophilus' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9FA0 
_struct_keywords.text            
'ScoC, Global regulator, Geobacillus stearothermophilus, DNA BINDING PROTEIN, Tetramer, DNA Bending, Hpr' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    9FA0 
_struct_ref.pdbx_db_accession          9FA0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9FA0 
_struct_ref_seq.pdbx_strand_id                B 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 207 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             9FA0 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  207 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       207 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 16020 ? 
1 MORE         -142  ? 
1 'SSA (A^2)'  33190 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3,4 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555  x,y,z                1.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
1.0000000000  0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 7_545  y+1/2,x-1/2,-z+1/2   0.0000000000  1.0000000000  0.0000000000 47.5910000000 1.0000000000  
0.0000000000  0.0000000000 -47.5910000000 0.0000000000 0.0000000000 -1.0000000000 78.0090000000 
3 'crystal symmetry operation' 10_655 -x+1,-y,z            -1.0000000000 0.0000000000  0.0000000000 95.1820000000 0.0000000000  
-1.0000000000 0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000  
4 'crystal symmetry operation' 16_555 -y+1/2,-x+1/2,-z+1/2 0.0000000000  -1.0000000000 0.0000000000 47.5910000000 -1.0000000000 
0.0000000000  0.0000000000 47.5910000000  0.0000000000 0.0000000000 -1.0000000000 78.0090000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? LYS A 40  ? SER B 9   LYS B 40  1 ? 32 
HELX_P HELX_P2  AA2 PRO A 41  ? ASP A 43  ? PRO B 41  ASP B 43  5 ? 3  
HELX_P HELX_P3  AA3 ASN A 45  ? LYS A 59  ? ASN B 45  LYS B 59  1 ? 15 
HELX_P HELX_P4  AA4 ILE A 63  ? VAL A 71  ? ILE B 63  VAL B 71  1 ? 9  
HELX_P HELX_P5  AA5 HIS A 73  ? LYS A 87  ? HIS B 73  LYS B 87  1 ? 15 
HELX_P HELX_P6  AA6 ASP A 98  ? ASN A 101 ? ASP B 98  ASN B 101 5 ? 4  
HELX_P HELX_P7  AA7 THR A 107 ? THR A 120 ? THR B 107 THR B 120 1 ? 14 
HELX_P HELX_P8  AA8 ASP A 122 ? LYS A 125 ? ASP B 122 LYS B 125 5 ? 4  
HELX_P HELX_P9  AA9 ASN A 126 ? GLY A 140 ? ASN B 126 GLY B 140 1 ? 15 
HELX_P HELX_P10 AB1 ILE A 145 ? GLY A 157 ? ILE B 145 GLY B 157 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 157 ? PHE A 175 ? GLY B 157 PHE B 175 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 61  ? SER A 62  ? ALA B 61  SER B 62  
AA1 2 TYR A 103 ? LEU A 106 ? TYR B 103 LEU B 106 
AA1 3 LEU A 90  ? PHE A 92  ? LEU B 90  PHE B 92  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 61  ? N ALA B 61  O ILE A 104 ? O ILE B 104 
AA1 2 3 O GLU A 105 ? O GLU B 105 N SER A 91  ? N SER B 91  
# 
_pdbx_entry_details.entry_id                   9FA0 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   ALA 
_pdbx_validate_close_contact.auth_seq_id_1    77 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OG 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   SER 
_pdbx_validate_close_contact.auth_seq_id_2    81 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.14 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OH 
_pdbx_validate_symm_contact.auth_asym_id_1    B 
_pdbx_validate_symm_contact.auth_comp_id_1    TYR 
_pdbx_validate_symm_contact.auth_seq_id_1     139 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OH 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    TYR 
_pdbx_validate_symm_contact.auth_seq_id_2     139 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   7_545 
_pdbx_validate_symm_contact.dist              2.06 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CE 
_pdbx_validate_rmsd_bond.auth_asym_id_1            B 
_pdbx_validate_rmsd_bond.auth_comp_id_1            LYS 
_pdbx_validate_rmsd_bond.auth_seq_id_1             116 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            NZ 
_pdbx_validate_rmsd_bond.auth_asym_id_2            B 
_pdbx_validate_rmsd_bond.auth_comp_id_2            LYS 
_pdbx_validate_rmsd_bond.auth_seq_id_2             116 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.643 
_pdbx_validate_rmsd_bond.bond_target_value         1.486 
_pdbx_validate_rmsd_bond.bond_deviation            0.157 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.025 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             B 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              146 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             B 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              146 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             B 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              146 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                100.21 
_pdbx_validate_rmsd_angle.angle_target_value         111.00 
_pdbx_validate_rmsd_angle.angle_deviation            -10.79 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.70 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    VAL 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     71 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             33.10 
_pdbx_validate_torsion.psi             59.79 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  -y+1/2,x,z+3/4       
3  y+1/2,-x,z+3/4       
4  x+1/2,-y,-z+3/4      
5  -x+1/2,y,-z+3/4      
6  -x,-y,z              
7  y,x,-z               
8  -y,-x,-z             
9  x+1/2,y+1/2,z+1/2    
10 -y+1,x+1/2,z+5/4     
11 y+1,-x+1/2,z+5/4     
12 x+1,-y+1/2,-z+5/4    
13 -x+1,y+1/2,-z+5/4    
14 -x+1/2,-y+1/2,z+1/2  
15 y+1/2,x+1/2,-z+1/2   
16 -y+1/2,-x+1/2,-z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B MET 1   ? A MET 1   
2  1 Y 1 B LYS 2   ? A LYS 2   
3  1 Y 1 B ALA 3   ? A ALA 3   
4  1 Y 1 B THR 4   ? A THR 4   
5  1 Y 1 B GLU 5   ? A GLU 5   
6  1 Y 1 B VAL 183 ? A VAL 183 
7  1 Y 1 B LYS 184 ? A LYS 184 
8  1 Y 1 B ARG 185 ? A ARG 185 
9  1 Y 1 B LYS 186 ? A LYS 186 
10 1 Y 1 B PRO 187 ? A PRO 187 
11 1 Y 1 B LYS 188 ? A LYS 188 
12 1 Y 1 B THR 189 ? A THR 189 
13 1 Y 1 B GLU 190 ? A GLU 190 
14 1 Y 1 B GLU 191 ? A GLU 191 
15 1 Y 1 B HIS 192 ? A HIS 192 
16 1 Y 1 B GLU 193 ? A GLU 193 
17 1 Y 1 B LYS 194 ? A LYS 194 
18 1 Y 1 B GLU 195 ? A GLU 195 
19 1 Y 1 B LEU 196 ? A LEU 196 
20 1 Y 1 B ALA 197 ? A ALA 197 
21 1 Y 1 B SER 198 ? A SER 198 
22 1 Y 1 B GLN 199 ? A GLN 199 
23 1 Y 1 B ALA 200 ? A ALA 200 
24 1 Y 1 B ASN 201 ? A ASN 201 
25 1 Y 1 B HIS 202 ? A HIS 202 
26 1 Y 1 B HIS 203 ? A HIS 203 
27 1 Y 1 B HIS 204 ? A HIS 204 
28 1 Y 1 B HIS 205 ? A HIS 205 
29 1 Y 1 B HIS 206 ? A HIS 206 
30 1 Y 1 B HIS 207 ? A HIS 207 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'Israel Science Foundation' 
_pdbx_audit_support.country                Israel 
_pdbx_audit_support.grant_number           500/10 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2FXA 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 41 2 2' 
_space_group.name_Hall        'I 4bw 2bw' 
_space_group.IT_number        98 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9FA0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010506 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010506 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006410 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 6.96715 ?       ? ? 11.43723 ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . GLN A 1 6   ? 52.75314 24.20563  46.77022 1.000 128.69790 ? 6   GLN B N   1 
ATOM 2    C CA  . GLN A 1 6   ? 51.42654 24.20783  46.15585 1.000 131.89562 ? 6   GLN B CA  1 
ATOM 3    C C   . GLN A 1 6   ? 51.35610 23.23977  44.95113 1.000 137.19773 ? 6   GLN B C   1 
ATOM 4    O O   . GLN A 1 6   ? 51.64665 22.05985  45.11066 1.000 140.54210 ? 6   GLN B O   1 
ATOM 5    C CB  . GLN A 1 6   ? 51.04578 25.62703  45.73893 1.000 139.11199 ? 6   GLN B CB  1 
ATOM 6    C CG  . GLN A 1 6   ? 49.68626 26.09552  46.25298 1.000 140.16790 ? 6   GLN B CG  1 
ATOM 7    C CD  . GLN A 1 6   ? 48.50950 25.55239  45.44510 1.000 137.08790 ? 6   GLN B CD  1 
ATOM 8    O OE1 . GLN A 1 6   ? 48.67626 25.07354  44.31855 1.000 136.03358 ? 6   GLN B OE1 1 
ATOM 9    N NE2 . GLN A 1 6   ? 47.30464 25.66464  46.00687 1.000 128.26829 ? 6   GLN B NE2 1 
ATOM 10   N N   . HIS A 1 7   ? 50.98823 23.73791  43.75836 1.000 136.83976 ? 7   HIS B N   1 
ATOM 11   C CA  . HIS A 1 7   ? 50.62604 22.92777  42.57880 1.000 134.28520 ? 7   HIS B CA  1 
ATOM 12   C C   . HIS A 1 7   ? 49.73647 21.72217  42.92160 1.000 128.78655 ? 7   HIS B C   1 
ATOM 13   O O   . HIS A 1 7   ? 49.79541 20.69034  42.24832 1.000 128.17252 ? 7   HIS B O   1 
ATOM 14   C CB  . HIS A 1 7   ? 51.85407 22.47751  41.75338 1.000 131.78918 ? 7   HIS B CB  1 
ATOM 15   C CG  . HIS A 1 7   ? 53.09150 22.21890  42.56130 1.000 135.64842 ? 7   HIS B CG  1 
ATOM 16   N ND1 . HIS A 1 7   ? 53.43149 20.97356  43.04001 1.000 137.58826 ? 7   HIS B ND1 1 
ATOM 17   C CD2 . HIS A 1 7   ? 54.10773 23.04318  42.91007 1.000 138.97771 ? 7   HIS B CD2 1 
ATOM 18   C CE1 . HIS A 1 7   ? 54.57941 21.05028  43.69229 1.000 139.15771 ? 7   HIS B CE1 1 
ATOM 19   N NE2 . HIS A 1 7   ? 55.01404 22.29371  43.62128 1.000 139.70771 ? 7   HIS B NE2 1 
ATOM 20   N N   . TYR A 1 8   ? 48.89714 21.86177  43.94929 1.000 122.64237 ? 8   TYR B N   1 
ATOM 21   C CA  . TYR A 1 8   ? 47.76324 20.99490  44.26285 1.000 116.04289 ? 8   TYR B CA  1 
ATOM 22   C C   . TYR A 1 8   ? 46.76558 21.82197  45.06303 1.000 117.64487 ? 8   TYR B C   1 
ATOM 23   O O   . TYR A 1 8   ? 47.12672 22.84740  45.64938 1.000 125.27955 ? 8   TYR B O   1 
ATOM 24   C CB  . TYR A 1 8   ? 48.18806 19.74146  45.04598 1.000 114.73207 ? 8   TYR B CB  1 
ATOM 25   C CG  . TYR A 1 8   ? 49.00194 19.97755  46.30512 1.000 106.30771 ? 8   TYR B CG  1 
ATOM 26   C CD1 . TYR A 1 8   ? 48.48626 20.65727  47.40396 1.000 110.03814 ? 8   TYR B CD1 1 
ATOM 27   C CD2 . TYR A 1 8   ? 50.31455 19.54814  46.36795 1.000 103.97074 ? 8   TYR B CD2 1 
ATOM 28   C CE1 . TYR A 1 8   ? 49.26504 20.87362  48.54418 1.000 113.81987 ? 8   TYR B CE1 1 
ATOM 29   C CE2 . TYR A 1 8   ? 51.09492 19.75940  47.48936 1.000 104.23008 ? 8   TYR B CE2 1 
ATOM 30   C CZ  . TYR A 1 8   ? 50.57665 20.42176  48.57593 1.000 105.96918 ? 8   TYR B CZ  1 
ATOM 31   O OH  . TYR A 1 8   ? 51.38544 20.61656  49.67860 1.000 90.37238  ? 8   TYR B OH  1 
ATOM 32   N N   . SER A 1 9   ? 45.50947 21.37416  45.09030 1.000 111.39267 ? 9   SER B N   1 
ATOM 33   C CA  . SER A 1 9   ? 44.51609 22.03831  45.92568 1.000 108.33452 ? 9   SER B CA  1 
ATOM 34   C C   . SER A 1 9   ? 44.63044 21.63638  47.38722 1.000 105.76402 ? 9   SER B C   1 
ATOM 35   O O   . SER A 1 9   ? 45.08382 20.54154  47.72190 1.000 111.37240 ? 9   SER B O   1 
ATOM 36   C CB  . SER A 1 9   ? 43.10227 21.71773  45.47078 1.000 108.23331 ? 9   SER B CB  1 
ATOM 37   O OG  . SER A 1 9   ? 42.19268 22.16045  46.46991 1.000 111.37219 ? 9   SER B OG  1 
ATOM 38   N N   . ILE A 1 10  ? 44.17274 22.52867  48.26297 1.000 105.05265 ? 10  ILE B N   1 
ATOM 39   C CA  . ILE A 1 10  ? 44.12061 22.20246  49.68469 1.000 104.65579 ? 10  ILE B CA  1 
ATOM 40   C C   . ILE A 1 10  ? 43.07414 21.11780  49.93228 1.000 104.14222 ? 10  ILE B C   1 
ATOM 41   O O   . ILE A 1 10  ? 43.32855 20.10463  50.60973 1.000 103.52818 ? 10  ILE B O   1 
ATOM 42   C CB  . ILE A 1 10  ? 43.83407 23.46481  50.52556 1.000 107.61612 ? 10  ILE B CB  1 
ATOM 43   C CG1 . ILE A 1 10  ? 44.62402 24.69868  50.04738 1.000 119.63953 ? 10  ILE B CG1 1 
ATOM 44   C CG2 . ILE A 1 10  ? 44.18191 23.20025  51.97020 1.000 100.89567 ? 10  ILE B CG2 1 
ATOM 45   C CD1 . ILE A 1 10  ? 44.02533 25.52577  48.89725 1.000 116.65999 ? 10  ILE B CD1 1 
ATOM 46   N N   . LYS A 1 11  ? 41.87577 21.32500  49.38977 1.000 105.11994 ? 11  LYS B N   1 
ATOM 47   C CA  . LYS A 1 11  ? 40.83367 20.30322  49.39822 1.000 101.29824 ? 11  LYS B CA  1 
ATOM 48   C C   . LYS A 1 11  ? 41.39603 18.93301  49.05486 1.000 97.82042  ? 11  LYS B C   1 
ATOM 49   O O   . LYS A 1 11  ? 41.21913 17.97388  49.81423 1.000 96.36281  ? 11  LYS B O   1 
ATOM 50   C CB  . LYS A 1 11  ? 39.75077 20.68556  48.38640 1.000 104.47188 ? 11  LYS B CB  1 
ATOM 51   C CG  . LYS A 1 11  ? 38.73594 21.69467  48.86496 1.000 106.28830 ? 11  LYS B CG  1 
ATOM 52   C CD  . LYS A 1 11  ? 37.72325 21.94950  47.76032 1.000 112.08983 ? 11  LYS B CD  1 
ATOM 53   C CE  . LYS A 1 11  ? 36.48452 22.68189  48.26306 1.000 116.90555 ? 11  LYS B CE  1 
ATOM 54   N NZ  . LYS A 1 11  ? 35.52390 22.92565  47.14433 1.000 112.45623 ? 11  LYS B NZ  1 
ATOM 55   N N   . GLU A 1 12  ? 42.04185 18.82763  47.89193 1.000 98.89810  ? 12  GLU B N   1 
ATOM 56   C CA  . GLU A 1 12  ? 42.60346 17.56481  47.44357 1.000 95.27200  ? 12  GLU B CA  1 
ATOM 57   C C   . GLU A 1 12  ? 43.39041 16.92288  48.56290 1.000 93.57960  ? 12  GLU B C   1 
ATOM 58   O O   . GLU A 1 12  ? 43.25541 15.71846  48.82748 1.000 95.65224  ? 12  GLU B O   1 
ATOM 59   C CB  . GLU A 1 12  ? 43.51529 17.81715  46.24414 1.000 102.57818 ? 12  GLU B CB  1 
ATOM 60   C CG  . GLU A 1 12  ? 42.81304 18.10153  44.92698 1.000 108.62449 ? 12  GLU B CG  1 
ATOM 61   C CD  . GLU A 1 12  ? 43.79572 18.42172  43.79194 1.000 126.32413 ? 12  GLU B CD  1 
ATOM 62   O OE1 . GLU A 1 12  ? 45.02119 18.18904  43.96372 1.000 123.06005 ? 12  GLU B OE1 1 
ATOM 63   O OE2 . GLU A 1 12  ? 43.33843 18.92226  42.73534 1.000 134.10776 ? 12  GLU B OE2 1 
ATOM 64   N N   . ALA A 1 13  ? 44.20642 17.72845  49.24291 1.000 86.00964  ? 13  ALA B N   1 
ATOM 65   C CA  . ALA A 1 13  ? 45.05701 17.19574  50.28776 1.000 85.35849  ? 13  ALA B CA  1 
ATOM 66   C C   . ALA A 1 13  ? 44.21942 16.59658  51.39700 1.000 88.18388  ? 13  ALA B C   1 
ATOM 67   O O   . ALA A 1 13  ? 44.50508 15.49388  51.87196 1.000 87.50857  ? 13  ALA B O   1 
ATOM 68   C CB  . ALA A 1 13  ? 45.96569 18.29271  50.82345 1.000 92.38351  ? 13  ALA B CB  1 
ATOM 69   N N   . MET A 1 14  ? 43.15163 17.29726  51.79522 1.000 94.18430  ? 14  MET B N   1 
ATOM 70   C CA  . MET A 1 14  ? 42.28688 16.78516  52.86200 1.000 89.31304  ? 14  MET B CA  1 
ATOM 71   C C   . MET A 1 14  ? 41.59664 15.49665  52.45129 1.000 85.05649  ? 14  MET B C   1 
ATOM 72   O O   . MET A 1 14  ? 41.49218 14.54562  53.24313 1.000 86.10863  ? 14  MET B O   1 
ATOM 73   C CB  . MET A 1 14  ? 41.26239 17.84160  53.27441 1.000 84.69435  ? 14  MET B CB  1 
ATOM 74   C CG  . MET A 1 14  ? 40.58485 17.49313  54.57528 1.000 87.04563  ? 14  MET B CG  1 
ATOM 75   S SD  . MET A 1 14  ? 41.79579 17.01762  55.81942 1.000 102.48336 ? 14  MET B SD  1 
ATOM 76   C CE  . MET A 1 14  ? 40.85429 17.09222  57.35196 1.000 106.75929 ? 14  MET B CE  1 
ATOM 77   N N   . LEU A 1 15  ? 41.13091 15.44176  51.21435 1.000 78.46181  ? 15  LEU B N   1 
ATOM 78   C CA  . LEU A 1 15  ? 40.47311 14.23699  50.75711 1.000 79.63754  ? 15  LEU B CA  1 
ATOM 79   C C   . LEU A 1 15  ? 41.43015 13.06805  50.83892 1.000 81.04729  ? 15  LEU B C   1 
ATOM 80   O O   . LEU A 1 15  ? 41.14279 12.04210  51.47635 1.000 78.70509  ? 15  LEU B O   1 
ATOM 81   C CB  . LEU A 1 15  ? 39.96440 14.44842  49.33648 1.000 88.30903  ? 15  LEU B CB  1 
ATOM 82   C CG  . LEU A 1 15  ? 38.89804 15.53889  49.22136 1.000 82.91582  ? 15  LEU B CG  1 
ATOM 83   C CD1 . LEU A 1 15  ? 38.31119 15.62006  47.83540 1.000 78.55434  ? 15  LEU B CD1 1 
ATOM 84   C CD2 . LEU A 1 15  ? 37.80071 15.19091  50.19168 1.000 89.75321  ? 15  LEU B CD2 1 
ATOM 85   N N   . PHE A 1 16  ? 42.60371 13.23877  50.24316 1.000 84.38967  ? 16  PHE B N   1 
ATOM 86   C CA  . PHE A 1 16  ? 43.55701 12.14794  50.19863 1.000 85.09602  ? 16  PHE B CA  1 
ATOM 87   C C   . PHE A 1 16  ? 43.92276 11.69457  51.60504 1.000 80.95660  ? 16  PHE B C   1 
ATOM 88   O O   . PHE A 1 16  ? 43.95929 10.48559  51.89021 1.000 77.71366  ? 16  PHE B O   1 
ATOM 89   C CB  . PHE A 1 16  ? 44.78840 12.58596  49.42746 1.000 79.55753  ? 16  PHE B CB  1 
ATOM 90   C CG  . PHE A 1 16  ? 45.86158 11.57013  49.41802 1.000 77.02648  ? 16  PHE B CG  1 
ATOM 91   C CD1 . PHE A 1 16  ? 45.81303 10.49686  48.54413 1.000 79.61582  ? 16  PHE B CD1 1 
ATOM 92   C CD2 . PHE A 1 16  ? 46.90734 11.66300  50.31438 1.000 78.55106  ? 16  PHE B CD2 1 
ATOM 93   C CE1 . PHE A 1 16  ? 46.81188 9.55666   48.54730 1.000 85.65268  ? 16  PHE B CE1 1 
ATOM 94   C CE2 . PHE A 1 16  ? 47.91142 10.72038  50.33723 1.000 75.74555  ? 16  PHE B CE2 1 
ATOM 95   C CZ  . PHE A 1 16  ? 47.86902 9.66667   49.45688 1.000 85.32440  ? 16  PHE B CZ  1 
ATOM 96   N N   . SER A 1 17  ? 44.17641 12.65953  52.49807 1.000 78.49362  ? 17  SER B N   1 
ATOM 97   C CA  . SER A 1 17  ? 44.56703 12.34613  53.86789 1.000 75.85541  ? 17  SER B CA  1 
ATOM 98   C C   . SER A 1 17  ? 43.54836 11.46793  54.54298 1.000 81.79261  ? 17  SER B C   1 
ATOM 99   O O   . SER A 1 17  ? 43.89483 10.42106  55.10694 1.000 87.21028  ? 17  SER B O   1 
ATOM 100  C CB  . SER A 1 17  ? 44.68854 13.61138  54.69374 1.000 81.53230  ? 17  SER B CB  1 
ATOM 101  O OG  . SER A 1 17  ? 45.39046 14.60534  53.98884 1.000 96.89150  ? 17  SER B OG  1 
ATOM 102  N N   . GLN A 1 18  ? 42.28891 11.91244  54.54587 1.000 82.31128  ? 18  GLN B N   1 
ATOM 103  C CA  . GLN A 1 18  ? 41.24229 11.15399  55.21288 1.000 70.09724  ? 18  GLN B CA  1 
ATOM 104  C C   . GLN A 1 18  ? 41.10416 9.77833   54.58971 1.000 70.11919  ? 18  GLN B C   1 
ATOM 105  O O   . GLN A 1 18  ? 41.01555 8.76152   55.29911 1.000 69.42058  ? 18  GLN B O   1 
ATOM 106  C CB  . GLN A 1 18  ? 39.94853 11.93854  55.11353 1.000 73.34730  ? 18  GLN B CB  1 
ATOM 107  C CG  . GLN A 1 18  ? 39.87358 13.08425  56.11723 1.000 80.55378  ? 18  GLN B CG  1 
ATOM 108  C CD  . GLN A 1 18  ? 38.54723 13.80426  56.08279 1.000 85.65155  ? 18  GLN B CD  1 
ATOM 109  O OE1 . GLN A 1 18  ? 37.94987 13.95407  55.01811 1.000 93.46790  ? 18  GLN B OE1 1 
ATOM 110  N NE2 . GLN A 1 18  ? 38.10548 14.30428  57.23008 1.000 87.60642  ? 18  GLN B NE2 1 
ATOM 111  N N   . ARG A 1 19  ? 41.13856 9.73747   53.25802 1.000 68.86934  ? 19  ARG B N   1 
ATOM 112  C CA  . ARG A 1 19  ? 40.98555 8.49076   52.52780 1.000 73.30391  ? 19  ARG B CA  1 
ATOM 113  C C   . ARG A 1 19  ? 42.01139 7.46451   52.99061 1.000 77.98324  ? 19  ARG B C   1 
ATOM 114  O O   . ARG A 1 19  ? 41.66411 6.34018   53.38821 1.000 72.86120  ? 19  ARG B O   1 
ATOM 115  C CB  . ARG A 1 19  ? 41.13196 8.78332   51.03496 1.000 72.89024  ? 19  ARG B CB  1 
ATOM 116  C CG  . ARG A 1 19  ? 40.88852 7.61953   50.12225 1.000 74.25076  ? 19  ARG B CG  1 
ATOM 117  C CD  . ARG A 1 19  ? 41.19588 8.01838   48.70866 1.000 77.68766  ? 19  ARG B CD  1 
ATOM 118  N NE  . ARG A 1 19  ? 40.25256 7.48797   47.72853 1.000 91.74778  ? 19  ARG B NE  1 
ATOM 119  C CZ  . ARG A 1 19  ? 40.56922 6.50157   46.89740 1.000 92.25671  ? 19  ARG B CZ  1 
ATOM 120  N NH1 . ARG A 1 19  ? 41.75721 5.93585   47.03509 1.000 89.33224  ? 19  ARG B NH1 1 
ATOM 121  N NH2 . ARG A 1 19  ? 39.71544 6.05316   45.97407 1.000 86.65005  ? 19  ARG B NH2 1 
ATOM 122  N N   . ILE A 1 20  ? 43.29041 7.84421   52.96463 1.000 75.56802  ? 20  ILE B N   1 
ATOM 123  C CA  . ILE A 1 20  ? 44.32109 6.87749   53.32278 1.000 73.35938  ? 20  ILE B CA  1 
ATOM 124  C C   . ILE A 1 20  ? 44.29617 6.57056   54.80378 1.000 69.86763  ? 20  ILE B C   1 
ATOM 125  O O   . ILE A 1 20  ? 44.63587 5.45543   55.21655 1.000 72.19187  ? 20  ILE B O   1 
ATOM 126  C CB  . ILE A 1 20  ? 45.72690 7.31176   52.86792 1.000 72.45322  ? 20  ILE B CB  1 
ATOM 127  C CG1 . ILE A 1 20  ? 46.65543 6.08760   52.91867 1.000 69.68087  ? 20  ILE B CG1 1 
ATOM 128  C CG2 . ILE A 1 20  ? 46.22207 8.49819   53.64402 1.000 75.69481  ? 20  ILE B CG2 1 
ATOM 129  C CD1 . ILE A 1 20  ? 47.96080 6.19663   52.17830 1.000 68.95862  ? 20  ILE B CD1 1 
ATOM 130  N N   . ALA A 1 21  ? 43.90582 7.52634   55.63456 1.000 67.85302  ? 21  ALA B N   1 
ATOM 131  C CA  . ALA A 1 21  ? 43.97218 7.24347   57.05793 1.000 74.04481  ? 21  ALA B CA  1 
ATOM 132  C C   . ALA A 1 21  ? 42.93177 6.18961   57.42712 1.000 78.35852  ? 21  ALA B C   1 
ATOM 133  O O   . ALA A 1 21  ? 43.21270 5.23680   58.16964 1.000 71.71947  ? 21  ALA B O   1 
ATOM 134  C CB  . ALA A 1 21  ? 43.80201 8.53706   57.85098 1.000 68.05899  ? 21  ALA B CB  1 
ATOM 135  N N   . GLN A 1 22  ? 41.73933 6.30603   56.84323 1.000 73.32811  ? 22  GLN B N   1 
ATOM 136  C CA  . GLN A 1 22  ? 40.70413 5.29915   57.05060 1.000 70.34541  ? 22  GLN B CA  1 
ATOM 137  C C   . GLN A 1 22  ? 41.07576 3.96242   56.41932 1.000 73.12481  ? 22  GLN B C   1 
ATOM 138  O O   . GLN A 1 22  ? 40.90165 2.89816   57.03069 1.000 71.44381  ? 22  GLN B O   1 
ATOM 139  C CB  . GLN A 1 22  ? 39.38967 5.84194   56.50577 1.000 68.26243  ? 22  GLN B CB  1 
ATOM 140  C CG  . GLN A 1 22  ? 38.18913 4.96341   56.66235 1.000 71.58655  ? 22  GLN B CG  1 
ATOM 141  C CD  . GLN A 1 22  ? 37.41401 5.26822   57.92391 1.000 73.31833  ? 22  GLN B CD  1 
ATOM 142  O OE1 . GLN A 1 22  ? 37.71546 6.22747   58.62533 1.000 76.28161  ? 22  GLN B OE1 1 
ATOM 143  N NE2 . GLN A 1 22  ? 36.35210 4.51772   58.16172 1.000 71.19353  ? 22  GLN B NE2 1 
ATOM 144  N N   . LEU A 1 23  ? 41.60782 3.98825   55.20662 1.000 71.06942  ? 23  LEU B N   1 
ATOM 145  C CA  . LEU A 1 23  ? 41.94863 2.72633   54.58245 1.000 71.55518  ? 23  LEU B CA  1 
ATOM 146  C C   . LEU A 1 23  ? 43.00166 2.01182   55.40343 1.000 72.68450  ? 23  LEU B C   1 
ATOM 147  O O   . LEU A 1 23  ? 42.92794 0.79439   55.61817 1.000 74.93458  ? 23  LEU B O   1 
ATOM 148  C CB  . LEU A 1 23  ? 42.43122 2.98502   53.16416 1.000 77.41303  ? 23  LEU B CB  1 
ATOM 149  C CG  . LEU A 1 23  ? 41.22835 3.20247   52.25295 1.000 84.96278  ? 23  LEU B CG  1 
ATOM 150  C CD1 . LEU A 1 23  ? 41.68807 3.76429   50.93567 1.000 82.39417  ? 23  LEU B CD1 1 
ATOM 151  C CD2 . LEU A 1 23  ? 40.45192 1.90852   52.05812 1.000 81.94198  ? 23  LEU B CD2 1 
ATOM 152  N N   . SER A 1 24  ? 43.95512 2.76933   55.93499 1.000 72.85892  ? 24  SER B N   1 
ATOM 153  C CA  . SER A 1 24  ? 45.09805 2.13431   56.55028 1.000 75.06800  ? 24  SER B CA  1 
ATOM 154  C C   . SER A 1 24  ? 44.72184 1.64037   57.92628 1.000 76.41677  ? 24  SER B C   1 
ATOM 155  O O   . SER A 1 24  ? 45.18940 0.58516   58.37138 1.000 75.27086  ? 24  SER B O   1 
ATOM 156  C CB  . SER A 1 24  ? 46.26827 3.10855   56.58186 1.000 72.68886  ? 24  SER B CB  1 
ATOM 157  O OG  . SER A 1 24  ? 47.24814 2.62326   57.47571 1.000 87.68954  ? 24  SER B OG  1 
ATOM 158  N N   . LYS A 1 25  ? 43.79573 2.34321   58.57554 1.000 81.26556  ? 25  LYS B N   1 
ATOM 159  C CA  . LYS A 1 25  ? 43.31462 1.85948   59.85583 1.000 81.64164  ? 25  LYS B CA  1 
ATOM 160  C C   . LYS A 1 25  ? 42.55696 0.56121   59.64661 1.000 73.61696  ? 25  LYS B C   1 
ATOM 161  O O   . LYS A 1 25  ? 42.74933 -0.41235  60.38714 1.000 72.10392  ? 25  LYS B O   1 
ATOM 162  C CB  . LYS A 1 25  ? 42.43536 2.92680   60.52973 1.000 74.07832  ? 25  LYS B CB  1 
ATOM 163  C CG  . LYS A 1 25  ? 42.05749 2.58310   61.95755 1.000 73.44339  ? 25  LYS B CG  1 
ATOM 164  C CD  . LYS A 1 25  ? 41.46480 3.78034   62.69907 1.000 79.70013  ? 25  LYS B CD  1 
ATOM 165  C CE  . LYS A 1 25  ? 41.03308 3.40753   64.12315 1.000 85.90894  ? 25  LYS B CE  1 
ATOM 166  N NZ  . LYS A 1 25  ? 40.61596 4.60741   64.91917 1.000 88.47573  ? 25  LYS B NZ  1 
ATOM 167  N N   . ALA A 1 26  ? 41.71630 0.51462   58.61178 1.000 70.20451  ? 26  ALA B N   1 
ATOM 168  C CA  . ALA A 1 26  ? 40.96067 -0.70310  58.37432 1.000 73.29698  ? 26  ALA B CA  1 
ATOM 169  C C   . ALA A 1 26  ? 41.90728 -1.87269  58.18537 1.000 77.84661  ? 26  ALA B C   1 
ATOM 170  O O   . ALA A 1 26  ? 41.80319 -2.90135  58.86918 1.000 76.08116  ? 26  ALA B O   1 
ATOM 171  C CB  . ALA A 1 26  ? 40.05854 -0.53571  57.15779 1.000 70.68001  ? 26  ALA B CB  1 
ATOM 172  N N   . LEU A 1 27  ? 42.86183 -1.70830  57.27656 1.000 76.35585  ? 27  LEU B N   1 
ATOM 173  C CA  . LEU A 1 27  ? 43.77538 -2.78803  56.94935 1.000 69.57174  ? 27  LEU B CA  1 
ATOM 174  C C   . LEU A 1 27  ? 44.58951 -3.23232  58.14354 1.000 76.71325  ? 27  LEU B C   1 
ATOM 175  O O   . LEU A 1 27  ? 44.77419 -4.43715  58.36787 1.000 80.84076  ? 27  LEU B O   1 
ATOM 176  C CB  . LEU A 1 27  ? 44.68876 -2.34271  55.83532 1.000 70.56390  ? 27  LEU B CB  1 
ATOM 177  C CG  . LEU A 1 27  ? 45.26331 -3.56814  55.18853 1.000 76.94357  ? 27  LEU B CG  1 
ATOM 178  C CD1 . LEU A 1 27  ? 44.17237 -4.57477  54.89016 1.000 84.13519  ? 27  LEU B CD1 1 
ATOM 179  C CD2 . LEU A 1 27  ? 45.95906 -3.12362  53.93060 1.000 83.83815  ? 27  LEU B CD2 1 
ATOM 180  N N   . TRP A 1 28  ? 45.11283 -2.28759  58.91411 1.000 73.32395  ? 28  TRP B N   1 
ATOM 181  C CA  . TRP A 1 28  ? 45.93432 -2.70911  60.02907 1.000 72.47344  ? 28  TRP B CA  1 
ATOM 182  C C   . TRP A 1 28  ? 45.09879 -3.47390  61.03628 1.000 78.47048  ? 28  TRP B C   1 
ATOM 183  O O   . TRP A 1 28  ? 45.53215 -4.50078  61.56279 1.000 76.21042  ? 28  TRP B O   1 
ATOM 184  C CB  . TRP A 1 28  ? 46.59975 -1.52070  60.69854 1.000 74.28642  ? 28  TRP B CB  1 
ATOM 185  C CG  . TRP A 1 28  ? 47.42635 -1.96240  61.82217 1.000 75.69384  ? 28  TRP B CG  1 
ATOM 186  C CD1 . TRP A 1 28  ? 47.44219 -1.42782  63.06750 1.000 77.34789  ? 28  TRP B CD1 1 
ATOM 187  C CD2 . TRP A 1 28  ? 48.39636 -3.02108  61.82467 1.000 79.07781  ? 28  TRP B CD2 1 
ATOM 188  N NE1 . TRP A 1 28  ? 48.33531 -2.09753  63.86245 1.000 82.77260  ? 28  TRP B NE1 1 
ATOM 189  C CE2 . TRP A 1 28  ? 48.92954 -3.08494  63.12095 1.000 76.98876  ? 28  TRP B CE2 1 
ATOM 190  C CE3 . TRP A 1 28  ? 48.84947 -3.93292  60.86622 1.000 77.21935  ? 28  TRP B CE3 1 
ATOM 191  C CZ2 . TRP A 1 28  ? 49.87993 -4.00951  63.47814 1.000 70.11512  ? 28  TRP B CZ2 1 
ATOM 192  C CZ3 . TRP A 1 28  ? 49.78652 -4.85691  61.23578 1.000 72.66813  ? 28  TRP B CZ3 1 
ATOM 193  C CH2 . TRP A 1 28  ? 50.29159 -4.88820  62.52424 1.000 70.77275  ? 28  TRP B CH2 1 
ATOM 194  N N   . LYS A 1 29  ? 43.86986 -3.01615  61.27492 1.000 82.88743  ? 29  LYS B N   1 
ATOM 195  C CA  . LYS A 1 29  ? 43.01714 -3.65465  62.26641 1.000 75.89993  ? 29  LYS B CA  1 
ATOM 196  C C   . LYS A 1 29  ? 42.62540 -5.07113  61.85621 1.000 76.37919  ? 29  LYS B C   1 
ATOM 197  O O   . LYS A 1 29  ? 42.59719 -5.98371  62.69389 1.000 79.21347  ? 29  LYS B O   1 
ATOM 198  C CB  . LYS A 1 29  ? 41.81500 -2.76346  62.48446 1.000 64.45822  ? 29  LYS B CB  1 
ATOM 199  C CG  . LYS A 1 29  ? 42.13958 -1.51153  63.30121 1.000 77.51184  ? 29  LYS B CG  1 
ATOM 200  C CD  . LYS A 1 29  ? 42.68226 -1.87696  64.70108 1.000 86.18692  ? 29  LYS B CD  1 
ATOM 201  C CE  . LYS A 1 29  ? 43.05805 -0.62902  65.52034 1.000 88.19650  ? 29  LYS B CE  1 
ATOM 202  N NZ  . LYS A 1 29  ? 43.52759 -0.90034  66.90654 1.000 84.11057  ? 29  LYS B NZ  1 
ATOM 203  N N   . SER A 1 30  ? 42.38513 -5.29412  60.56531 1.000 70.87064  ? 30  SER B N   1 
ATOM 204  C CA  . SER A 1 30  ? 42.03092 -6.64103  60.12098 1.000 75.03127  ? 30  SER B CA  1 
ATOM 205  C C   . SER A 1 30  ? 43.20613 -7.58584  60.24394 1.000 83.32380  ? 30  SER B C   1 
ATOM 206  O O   . SER A 1 30  ? 43.06460 -8.72894  60.71469 1.000 87.17223  ? 30  SER B O   1 
ATOM 207  C CB  . SER A 1 30  ? 41.56923 -6.62495  58.67781 1.000 76.94262  ? 30  SER B CB  1 
ATOM 208  O OG  . SER A 1 30  ? 40.73731 -5.51865  58.45302 1.000 89.49475  ? 30  SER B OG  1 
ATOM 209  N N   . ILE A 1 31  ? 44.37063 -7.14324  59.76610 1.000 87.40613  ? 31  ILE B N   1 
ATOM 210  C CA  . ILE A 1 31  ? 45.54605 -7.99860  59.85272 1.000 84.91689  ? 31  ILE B CA  1 
ATOM 211  C C   . ILE A 1 31  ? 45.87140 -8.27853  61.30439 1.000 82.01365  ? 31  ILE B C   1 
ATOM 212  O O   . ILE A 1 31  ? 46.22010 -9.40320  61.67816 1.000 79.61220  ? 31  ILE B O   1 
ATOM 213  C CB  . ILE A 1 31  ? 46.73157 -7.37305  59.09390 1.000 73.70470  ? 31  ILE B CB  1 
ATOM 214  C CG1 . ILE A 1 31  ? 46.40078 -7.22232  57.60869 1.000 70.85520  ? 31  ILE B CG1 1 
ATOM 215  C CG2 . ILE A 1 31  ? 47.98579 -8.18494  59.29062 1.000 80.39339  ? 31  ILE B CG2 1 
ATOM 216  C CD1 . ILE A 1 31  ? 47.50404 -6.66819  56.83636 1.000 76.84621  ? 31  ILE B CD1 1 
ATOM 217  N N   . GLU A 1 32  ? 45.69225 -7.27148  62.15192 1.000 80.08544  ? 32  GLU B N   1 
ATOM 218  C CA  . GLU A 1 32  ? 45.94801 -7.42259  63.57050 1.000 80.13092  ? 32  GLU B CA  1 
ATOM 219  C C   . GLU A 1 32  ? 45.06923 -8.52776  64.14815 1.000 85.51401  ? 32  GLU B C   1 
ATOM 220  O O   . GLU A 1 32  ? 45.55270 -9.41478  64.86415 1.000 83.88439  ? 32  GLU B O   1 
ATOM 221  C CB  . GLU A 1 32  ? 45.70947 -6.06116  64.23907 1.000 77.06223  ? 32  GLU B CB  1 
ATOM 222  C CG  . GLU A 1 32  ? 46.71131 -5.59154  65.27090 1.000 80.45780  ? 32  GLU B CG  1 
ATOM 223  C CD  . GLU A 1 32  ? 46.51037 -4.11457  65.61445 1.000 92.04286  ? 32  GLU B CD  1 
ATOM 224  O OE1 . GLU A 1 32  ? 45.86869 -3.42278  64.79589 1.000 88.77023  ? 32  GLU B OE1 1 
ATOM 225  O OE2 . GLU A 1 32  ? 46.95545 -3.64269  66.69413 1.000 99.27877  ? 32  GLU B OE2 1 
ATOM 226  N N   . LYS A 1 33  ? 43.78236 -8.52964  63.77532 1.000 86.34063  ? 33  LYS B N   1 
ATOM 227  C CA  . LYS A 1 33  ? 42.84057 -9.48103  64.35781 1.000 86.04897  ? 33  LYS B CA  1 
ATOM 228  C C   . LYS A 1 33  ? 43.11658 -10.89725 63.88167 1.000 90.30652  ? 33  LYS B C   1 
ATOM 229  O O   . LYS A 1 33  ? 43.15310 -11.84179 64.68505 1.000 93.09000  ? 33  LYS B O   1 
ATOM 230  C CB  . LYS A 1 33  ? 41.41488 -9.08180  64.01443 1.000 86.52551  ? 33  LYS B CB  1 
ATOM 231  C CG  . LYS A 1 33  ? 40.35599 -10.00057 64.62324 1.000 100.50795 ? 33  LYS B CG  1 
ATOM 232  C CD  . LYS A 1 33  ? 38.94701 -9.48476  64.33766 1.000 92.59795  ? 33  LYS B CD  1 
ATOM 233  C CE  . LYS A 1 33  ? 38.81566 -9.02144  62.88627 1.000 98.59795  ? 33  LYS B CE  1 
ATOM 234  N NZ  . LYS A 1 33  ? 39.27507 -10.03358 61.85941 1.000 105.65795 ? 33  LYS B NZ  1 
ATOM 235  N N   . ASP A 1 34  ? 43.30259 -11.06802 62.57396 1.000 87.42992  ? 34  ASP B N   1 
ATOM 236  C CA  . ASP A 1 34  ? 43.64720 -12.39192 62.05362 1.000 91.65503  ? 34  ASP B CA  1 
ATOM 237  C C   . ASP A 1 34  ? 44.95130 -12.90528 62.66465 1.000 94.42761  ? 34  ASP B C   1 
ATOM 238  O O   . ASP A 1 34  ? 45.02832 -14.05009 63.13082 1.000 100.87898 ? 34  ASP B O   1 
ATOM 239  C CB  . ASP A 1 34  ? 43.78963 -12.33315 60.53110 1.000 94.26612  ? 34  ASP B CB  1 
ATOM 240  C CG  . ASP A 1 34  ? 42.54768 -11.82182 59.83324 1.000 98.81409  ? 34  ASP B CG  1 
ATOM 241  O OD1 . ASP A 1 34  ? 41.46477 -11.70999 60.47340 1.000 102.28817 ? 34  ASP B OD1 1 
ATOM 242  O OD2 . ASP A 1 34  ? 42.69624 -11.46114 58.64467 1.000 95.74911  ? 34  ASP B OD2 1 
ATOM 243  N N   . TRP A 1 35  ? 45.99302 -12.07922 62.63251 1.000 92.71604  ? 35  TRP B N   1 
ATOM 244  C CA  . TRP A 1 35  ? 47.29541 -12.46805 63.13911 1.000 88.52641  ? 35  TRP B CA  1 
ATOM 245  C C   . TRP A 1 35  ? 47.18750 -12.90671 64.58741 1.000 91.20746  ? 35  TRP B C   1 
ATOM 246  O O   . TRP A 1 35  ? 47.70116 -13.96817 64.96493 1.000 99.56593  ? 35  TRP B O   1 
ATOM 247  C CB  . TRP A 1 35  ? 48.25443 -11.27640 62.98643 1.000 90.87507  ? 35  TRP B CB  1 
ATOM 248  C CG  . TRP A 1 35  ? 49.72493 -11.56499 63.11044 1.000 86.97688  ? 35  TRP B CG  1 
ATOM 249  C CD1 . TRP A 1 35  ? 50.29288 -12.70879 63.57095 1.000 89.39243  ? 35  TRP B CD1 1 
ATOM 250  C CD2 . TRP A 1 35  ? 50.80553 -10.65585 62.85596 1.000 83.55366  ? 35  TRP B CD2 1 
ATOM 251  N NE1 . TRP A 1 35  ? 51.65571 -12.59183 63.57439 1.000 84.13192  ? 35  TRP B NE1 1 
ATOM 252  C CE2 . TRP A 1 35  ? 51.99966 -11.34055 63.14533 1.000 84.07510  ? 35  TRP B CE2 1 
ATOM 253  C CE3 . TRP A 1 35  ? 50.88096 -9.33799  62.38887 1.000 87.88808  ? 35  TRP B CE3 1 
ATOM 254  C CZ2 . TRP A 1 35  ? 53.26367 -10.75446 62.99517 1.000 89.51587  ? 35  TRP B CZ2 1 
ATOM 255  C CZ3 . TRP A 1 35  ? 52.14514 -8.74856  62.23595 1.000 84.57861  ? 35  TRP B CZ3 1 
ATOM 256  C CH2 . TRP A 1 35  ? 53.31631 -9.46313  62.53786 1.000 86.82785  ? 35  TRP B CH2 1 
ATOM 257  N N   . GLN A 1 36  ? 46.51381 -12.10312 65.41113 1.000 86.41068  ? 36  GLN B N   1 
ATOM 258  C CA  . GLN A 1 36  ? 46.34686 -12.44808 66.81390 1.000 91.97331  ? 36  GLN B CA  1 
ATOM 259  C C   . GLN A 1 36  ? 45.63327 -13.77784 66.96022 1.000 99.68478  ? 36  GLN B C   1 
ATOM 260  O O   . GLN A 1 36  ? 45.94904 -14.56544 67.85966 1.000 102.34123 ? 36  GLN B O   1 
ATOM 261  C CB  . GLN A 1 36  ? 45.54290 -11.36850 67.50970 1.000 93.39207  ? 36  GLN B CB  1 
ATOM 262  C CG  . GLN A 1 36  ? 46.30936 -10.15769 67.85859 1.000 92.33402  ? 36  GLN B CG  1 
ATOM 263  C CD  . GLN A 1 36  ? 45.37887 -9.04587  68.27391 1.000 99.83362  ? 36  GLN B CD  1 
ATOM 264  O OE1 . GLN A 1 36  ? 44.15858 -9.22780  68.29127 1.000 111.98030 ? 36  GLN B OE1 1 
ATOM 265  N NE2 . GLN A 1 36  ? 45.93934 -7.88958  68.61884 1.000 101.70080 ? 36  GLN B NE2 1 
ATOM 266  N N   . ARG A 1 37  ? 44.64899 -14.03887 66.09613 1.000 97.09558  ? 37  ARG B N   1 
ATOM 267  C CA  . ARG A 1 37  ? 44.00801 -15.34350 66.13324 1.000 99.23366  ? 37  ARG B CA  1 
ATOM 268  C C   . ARG A 1 37  ? 45.02955 -16.44945 65.92861 1.000 99.13833  ? 37  ARG B C   1 
ATOM 269  O O   . ARG A 1 37  ? 45.08728 -17.40267 66.71089 1.000 104.45259 ? 37  ARG B O   1 
ATOM 270  C CB  . ARG A 1 37  ? 42.92818 -15.44189 65.06744 1.000 99.19683  ? 37  ARG B CB  1 
ATOM 271  C CG  . ARG A 1 37  ? 42.72489 -16.87111 64.64282 1.000 96.98226  ? 37  ARG B CG  1 
ATOM 272  C CD  . ARG A 1 37  ? 41.46792 -17.07520 63.86882 1.000 94.86127  ? 37  ARG B CD  1 
ATOM 273  N NE  . ARG A 1 37  ? 41.35481 -16.15195 62.75090 1.000 97.62816  ? 37  ARG B NE  1 
ATOM 274  C CZ  . ARG A 1 37  ? 40.65715 -15.02099 62.77542 1.000 104.06850 ? 37  ARG B CZ  1 
ATOM 275  N NH1 . ARG A 1 37  ? 39.98643 -14.67134 63.86931 1.000 101.02273 ? 37  ARG B NH1 1 
ATOM 276  N NH2 . ARG A 1 37  ? 40.61365 -14.24363 61.69598 1.000 103.95960 ? 37  ARG B NH2 1 
ATOM 277  N N   . TRP A 1 38  ? 45.84478 -16.32648 64.87647 1.000 99.71348  ? 38  TRP B N   1 
ATOM 278  C CA  . TRP A 1 38  ? 46.78901 -17.38276 64.50196 1.000 99.52780  ? 38  TRP B CA  1 
ATOM 279  C C   . TRP A 1 38  ? 47.77920 -17.67387 65.61704 1.000 103.36341 ? 38  TRP B C   1 
ATOM 280  O O   . TRP A 1 38  ? 48.10753 -18.83703 65.88815 1.000 105.96026 ? 38  TRP B O   1 
ATOM 281  C CB  . TRP A 1 38  ? 47.53149 -16.97927 63.23150 1.000 94.66097  ? 38  TRP B CB  1 
ATOM 282  C CG  . TRP A 1 38  ? 48.56410 -17.93054 62.72937 1.000 100.23192 ? 38  TRP B CG  1 
ATOM 283  C CD1 . TRP A 1 38  ? 48.53031 -19.29830 62.75646 1.000 109.30802 ? 38  TRP B CD1 1 
ATOM 284  C CD2 . TRP A 1 38  ? 49.78724 -17.57159 62.07695 1.000 105.71693 ? 38  TRP B CD2 1 
ATOM 285  N NE1 . TRP A 1 38  ? 49.67476 -19.81170 62.16927 1.000 110.71857 ? 38  TRP B NE1 1 
ATOM 286  C CE2 . TRP A 1 38  ? 50.45787 -18.76876 61.74234 1.000 108.45898 ? 38  TRP B CE2 1 
ATOM 287  C CE3 . TRP A 1 38  ? 50.38480 -16.35031 61.75003 1.000 97.75474  ? 38  TRP B CE3 1 
ATOM 288  C CZ2 . TRP A 1 38  ? 51.69410 -18.77351 61.08971 1.000 106.73322 ? 38  TRP B CZ2 1 
ATOM 289  C CZ3 . TRP A 1 38  ? 51.61280 -16.35963 61.10682 1.000 95.41360  ? 38  TRP B CZ3 1 
ATOM 290  C CH2 . TRP A 1 38  ? 52.25252 -17.56141 60.78274 1.000 103.97425 ? 38  TRP B CH2 1 
ATOM 291  N N   . ILE A 1 39  ? 48.25613 -16.62843 66.28685 1.000 103.56629 ? 39  ILE B N   1 
ATOM 292  C CA  . ILE A 1 39  ? 49.37000 -16.79657 67.21063 1.000 102.13474 ? 39  ILE B CA  1 
ATOM 293  C C   . ILE A 1 39  ? 48.93851 -16.92109 68.67563 1.000 107.41964 ? 39  ILE B C   1 
ATOM 294  O O   . ILE A 1 39  ? 49.76247 -17.33203 69.50856 1.000 107.64307 ? 39  ILE B O   1 
ATOM 295  C CB  . ILE A 1 39  ? 50.43246 -15.68419 66.98252 1.000 95.35758  ? 39  ILE B CB  1 
ATOM 296  C CG1 . ILE A 1 39  ? 49.87374 -14.23971 66.98982 1.000 85.80038  ? 39  ILE B CG1 1 
ATOM 297  C CG2 . ILE A 1 39  ? 51.11435 -15.90949 65.65850 1.000 96.14666  ? 39  ILE B CG2 1 
ATOM 298  C CD1 . ILE A 1 39  ? 49.35837 -13.70304 68.28512 1.000 97.17951  ? 39  ILE B CD1 1 
ATOM 299  N N   . LYS A 1 40  ? 47.66970 -16.64659 69.01252 1.000 107.70238 ? 40  LYS B N   1 
ATOM 300  C CA  . LYS A 1 40  ? 47.25955 -16.69205 70.41599 1.000 109.03725 ? 40  LYS B CA  1 
ATOM 301  C C   . LYS A 1 40  ? 47.40380 -18.07277 71.05729 1.000 111.36650 ? 40  LYS B C   1 
ATOM 302  O O   . LYS A 1 40  ? 47.67668 -18.12670 72.26885 1.000 114.60191 ? 40  LYS B O   1 
ATOM 303  C CB  . LYS A 1 40  ? 45.82197 -16.16343 70.54614 1.000 109.94733 ? 40  LYS B CB  1 
ATOM 304  C CG  . LYS A 1 40  ? 45.33133 -16.01826 71.99306 1.000 115.37786 ? 40  LYS B CG  1 
ATOM 305  C CD  . LYS A 1 40  ? 43.90309 -15.48729 72.07456 1.000 118.11821 ? 40  LYS B CD  1 
ATOM 306  C CE  . LYS A 1 40  ? 43.49803 -15.16892 73.51871 1.000 116.91829 ? 40  LYS B CE  1 
ATOM 307  N NZ  . LYS A 1 40  ? 43.60955 -16.33844 74.43565 1.000 123.33652 ? 40  LYS B NZ  1 
ATOM 308  N N   . PRO A 1 41  ? 47.24974 -19.20095 70.34101 1.000 106.60925 ? 41  PRO B N   1 
ATOM 309  C CA  . PRO A 1 41  ? 47.57194 -20.49466 70.96723 1.000 104.92046 ? 41  PRO B CA  1 
ATOM 310  C C   . PRO A 1 41  ? 48.90308 -20.51256 71.71472 1.000 111.59720 ? 41  PRO B C   1 
ATOM 311  O O   . PRO A 1 41  ? 48.98127 -21.04640 72.83013 1.000 112.53565 ? 41  PRO B O   1 
ATOM 312  C CB  . PRO A 1 41  ? 47.59380 -21.44876 69.76183 1.000 100.98080 ? 41  PRO B CB  1 
ATOM 313  C CG  . PRO A 1 41  ? 46.57488 -20.91787 68.87885 1.000 101.70926 ? 41  PRO B CG  1 
ATOM 314  C CD  . PRO A 1 41  ? 46.63048 -19.41596 69.01729 1.000 106.68706 ? 41  PRO B CD  1 
ATOM 315  N N   . PHE A 1 42  ? 49.94034 -19.89730 71.14991 1.000 109.77530 ? 42  PHE B N   1 
ATOM 316  C CA  . PHE A 1 42  ? 51.30362 -20.02936 71.64111 1.000 103.31835 ? 42  PHE B CA  1 
ATOM 317  C C   . PHE A 1 42  ? 51.67548 -18.93426 72.63491 1.000 105.28493 ? 42  PHE B C   1 
ATOM 318  O O   . PHE A 1 42  ? 52.84869 -18.81614 73.00346 1.000 107.15225 ? 42  PHE B O   1 
ATOM 319  C CB  . PHE A 1 42  ? 52.29185 -20.02585 70.46563 1.000 99.40986  ? 42  PHE B CB  1 
ATOM 320  C CG  . PHE A 1 42  ? 52.08851 -21.14686 69.46563 1.000 98.12396  ? 42  PHE B CG  1 
ATOM 321  C CD1 . PHE A 1 42  ? 50.87556 -21.32665 68.81913 1.000 102.55026 ? 42  PHE B CD1 1 
ATOM 322  C CD2 . PHE A 1 42  ? 53.13602 -21.99238 69.14149 1.000 105.30543 ? 42  PHE B CD2 1 
ATOM 323  C CE1 . PHE A 1 42  ? 50.69701 -22.34007 67.90225 1.000 111.29429 ? 42  PHE B CE1 1 
ATOM 324  C CE2 . PHE A 1 42  ? 52.97142 -23.01350 68.20636 1.000 111.51208 ? 42  PHE B CE2 1 
ATOM 325  C CZ  . PHE A 1 42  ? 51.74727 -23.18352 67.58714 1.000 113.51922 ? 42  PHE B CZ  1 
ATOM 326  N N   . ASP A 1 43  ? 50.70344 -18.13875 73.07569 1.000 105.77052 ? 43  ASP B N   1 
ATOM 327  C CA  . ASP A 1 43  ? 50.92010 -17.07746 74.05953 1.000 108.00998 ? 43  ASP B CA  1 
ATOM 328  C C   . ASP A 1 43  ? 51.97995 -16.08851 73.57983 1.000 105.98531 ? 43  ASP B C   1 
ATOM 329  O O   . ASP A 1 43  ? 52.99083 -15.85478 74.24142 1.000 108.49391 ? 43  ASP B O   1 
ATOM 330  C CB  . ASP A 1 43  ? 51.29728 -17.65578 75.42131 1.000 111.16461 ? 43  ASP B CB  1 
ATOM 331  C CG  . ASP A 1 43  ? 51.29906 -16.60549 76.52186 1.000 123.98461 ? 43  ASP B CG  1 
ATOM 332  O OD1 . ASP A 1 43  ? 51.03854 -15.41143 76.23305 1.000 124.03693 ? 43  ASP B OD1 1 
ATOM 333  O OD2 . ASP A 1 43  ? 51.55360 -16.97628 77.68639 1.000 131.49962 ? 43  ASP B OD2 1 
ATOM 334  N N   . LEU A 1 44  ? 51.72721 -15.48697 72.42581 1.000 108.07385 ? 44  LEU B N   1 
ATOM 335  C CA  . LEU A 1 44  ? 52.64445 -14.54208 71.81704 1.000 98.54475  ? 44  LEU B CA  1 
ATOM 336  C C   . LEU A 1 44  ? 51.89971 -13.27701 71.47211 1.000 95.22618  ? 44  LEU B C   1 
ATOM 337  O O   . LEU A 1 44  ? 50.83452 -13.32775 70.86510 1.000 97.71457  ? 44  LEU B O   1 
ATOM 338  C CB  . LEU A 1 44  ? 53.27640 -15.11087 70.54000 1.000 99.45768  ? 44  LEU B CB  1 
ATOM 339  C CG  . LEU A 1 44  ? 54.28951 -16.23657 70.74059 1.000 99.01317  ? 44  LEU B CG  1 
ATOM 340  C CD1 . LEU A 1 44  ? 54.74457 -16.84996 69.42801 1.000 87.98239  ? 44  LEU B CD1 1 
ATOM 341  C CD2 . LEU A 1 44  ? 55.47614 -15.70533 71.52416 1.000 103.85487 ? 44  LEU B CD2 1 
ATOM 342  N N   . ASN A 1 45  ? 52.46091 -12.15252 71.86452 1.000 94.99394  ? 45  ASN B N   1 
ATOM 343  C CA  . ASN A 1 45  ? 51.97815 -10.88034 71.38008 1.000 92.11427  ? 45  ASN B CA  1 
ATOM 344  C C   . ASN A 1 45  ? 52.31589 -10.77525 69.87470 1.000 100.07774 ? 45  ASN B C   1 
ATOM 345  O O   . ASN A 1 45  ? 53.12431 -11.54919 69.34416 1.000 98.62376  ? 45  ASN B O   1 
ATOM 346  C CB  . ASN A 1 45  ? 52.61355 -9.78799  72.24756 1.000 85.62452  ? 45  ASN B CB  1 
ATOM 347  C CG  . ASN A 1 45  ? 52.18716 -8.40469  71.86727 1.000 102.59034 ? 45  ASN B CG  1 
ATOM 348  O OD1 . ASN A 1 45  ? 52.26295 -8.00683  70.70317 1.000 103.98710 ? 45  ASN B OD1 1 
ATOM 349  N ND2 . ASN A 1 45  ? 51.72707 -7.63919  72.86480 1.000 103.48027 ? 45  ASN B ND2 1 
ATOM 350  N N   . ILE A 1 46  ? 51.63361 -9.86266  69.16280 1.000 99.94364  ? 46  ILE B N   1 
ATOM 351  C CA  . ILE A 1 46  ? 51.98178 -9.58935  67.75923 1.000 95.47005  ? 46  ILE B CA  1 
ATOM 352  C C   . ILE A 1 46  ? 53.44940 -9.17429  67.63247 1.000 97.06448  ? 46  ILE B C   1 
ATOM 353  O O   . ILE A 1 46  ? 54.20750 -9.72147  66.81102 1.000 94.30550  ? 46  ILE B O   1 
ATOM 354  C CB  . ILE A 1 46  ? 51.04312 -8.51396  67.16176 1.000 95.37841  ? 46  ILE B CB  1 
ATOM 355  C CG1 . ILE A 1 46  ? 49.64828 -9.01637  66.83338 1.000 84.64596  ? 46  ILE B CG1 1 
ATOM 356  C CG2 . ILE A 1 46  ? 51.57476 -8.02976  65.83813 1.000 93.88026  ? 46  ILE B CG2 1 
ATOM 357  C CD1 . ILE A 1 46  ? 49.65226 -10.35469 66.20437 1.000 95.31343  ? 46  ILE B CD1 1 
ATOM 358  N N   . ASN A 1 47  ? 53.86355 -8.18454  68.43273 1.000 94.85661  ? 47  ASN B N   1 
ATOM 359  C CA  . ASN A 1 47  ? 55.25155 -7.73190  68.43147 1.000 91.29786  ? 47  ASN B CA  1 
ATOM 360  C C   . ASN A 1 47  ? 56.22367 -8.88788  68.60603 1.000 93.15076  ? 47  ASN B C   1 
ATOM 361  O O   . ASN A 1 47  ? 57.23731 -8.95861  67.91114 1.000 96.75807  ? 47  ASN B O   1 
ATOM 362  C CB  . ASN A 1 47  ? 55.46031 -6.67972  69.52328 1.000 85.57979  ? 47  ASN B CB  1 
ATOM 363  C CG  . ASN A 1 47  ? 54.57954 -5.43473  69.33437 1.000 98.50153  ? 47  ASN B CG  1 
ATOM 364  O OD1 . ASN A 1 47  ? 54.91950 -4.51856  68.57560 1.000 89.24210  ? 47  ASN B OD1 1 
ATOM 365  N ND2 . ASN A 1 47  ? 53.40729 -5.43915  69.96363 1.000 111.35964 ? 47  ASN B ND2 1 
ATOM 366  N N   . GLU A 1 48  ? 55.92451 -9.81040  69.51357 1.000 90.35941  ? 48  GLU B N   1 
ATOM 367  C CA  . GLU A 1 48  ? 56.86189 -10.87938 69.83258 1.000 88.56146  ? 48  GLU B CA  1 
ATOM 368  C C   . GLU A 1 48  ? 57.08885 -11.79436 68.63826 1.000 91.33514  ? 48  GLU B C   1 
ATOM 369  O O   . GLU A 1 48  ? 58.22858 -12.15487 68.31001 1.000 88.46212  ? 48  GLU B O   1 
ATOM 370  C CB  . GLU A 1 48  ? 56.31726 -11.66045 71.01794 1.000 89.29230  ? 48  GLU B CB  1 
ATOM 371  C CG  . GLU A 1 48  ? 56.16572 -10.80033 72.26302 1.000 95.93874  ? 48  GLU B CG  1 
ATOM 372  C CD  . GLU A 1 48  ? 55.75336 -11.59786 73.48460 1.000 101.16479 ? 48  GLU B CD  1 
ATOM 373  O OE1 . GLU A 1 48  ? 55.22109 -12.71043 73.29965 1.000 104.86631 ? 48  GLU B OE1 1 
ATOM 374  O OE2 . GLU A 1 48  ? 55.95400 -11.11086 74.62129 1.000 99.84408  ? 48  GLU B OE2 1 
ATOM 375  N N   . HIS A 1 49  ? 56.01530 -12.18986 67.97495 1.000 92.65460  ? 49  HIS B N   1 
ATOM 376  C CA  . HIS A 1 49  ? 56.18212 -12.98156 66.76559 1.000 94.65594  ? 49  HIS B CA  1 
ATOM 377  C C   . HIS A 1 49  ? 56.97674 -12.20506 65.71076 1.000 94.60706  ? 49  HIS B C   1 
ATOM 378  O O   . HIS A 1 49  ? 57.90170 -12.74689 65.08266 1.000 88.63859  ? 49  HIS B O   1 
ATOM 379  C CB  . HIS A 1 49  ? 54.80235 -13.39148 66.24986 1.000 88.34983  ? 49  HIS B CB  1 
ATOM 380  C CG  . HIS A 1 49  ? 54.83950 -14.39231 65.14186 1.000 92.14373  ? 49  HIS B CG  1 
ATOM 381  N ND1 . HIS A 1 49  ? 54.28149 -14.15228 63.90421 1.000 94.34524  ? 49  HIS B ND1 1 
ATOM 382  C CD2 . HIS A 1 49  ? 55.36986 -15.63547 65.07882 1.000 101.37883 ? 49  HIS B CD2 1 
ATOM 383  C CE1 . HIS A 1 49  ? 54.46898 -15.20394 63.12570 1.000 96.35343  ? 49  HIS B CE1 1 
ATOM 384  N NE2 . HIS A 1 49  ? 55.12768 -16.11819 63.81359 1.000 100.90143 ? 49  HIS B NE2 1 
ATOM 385  N N   . HIS A 1 50  ? 56.63635 -10.92320 65.52160 1.000 91.89001  ? 50  HIS B N   1 
ATOM 386  C CA  . HIS A 1 50  ? 57.36307 -10.07700 64.57600 1.000 87.95221  ? 50  HIS B CA  1 
ATOM 387  C C   . HIS A 1 50  ? 58.85352 -10.06826 64.86810 1.000 90.69735  ? 50  HIS B C   1 
ATOM 388  O O   . HIS A 1 50  ? 59.68788 -10.15363 63.95266 1.000 92.33821  ? 50  HIS B O   1 
ATOM 389  C CB  . HIS A 1 50  ? 56.77354 -8.66538  64.61624 1.000 90.78999  ? 50  HIS B CB  1 
ATOM 390  C CG  . HIS A 1 50  ? 57.03938 -7.85762  63.38567 1.000 85.42563  ? 50  HIS B CG  1 
ATOM 391  N ND1 . HIS A 1 50  ? 57.47285 -8.42878  62.20965 1.000 85.91017  ? 50  HIS B ND1 1 
ATOM 392  C CD2 . HIS A 1 50  ? 56.77467 -6.55991  63.09786 1.000 76.71271  ? 50  HIS B CD2 1 
ATOM 393  C CE1 . HIS A 1 50  ? 57.56867 -7.49461  61.28119 1.000 82.25376  ? 50  HIS B CE1 1 
ATOM 394  N NE2 . HIS A 1 50  ? 57.12974 -6.35696  61.78706 1.000 76.45171  ? 50  HIS B NE2 1 
ATOM 395  N N   . ILE A 1 51  ? 59.19944 -10.01405 66.14739 1.000 89.52363  ? 51  ILE B N   1 
ATOM 396  C CA  . ILE A 1 51  ? 60.59317 -9.96556  66.55722 1.000 89.10355  ? 51  ILE B CA  1 
ATOM 397  C C   . ILE A 1 51  ? 61.26976 -11.28624 66.22599 1.000 91.04637  ? 51  ILE B C   1 
ATOM 398  O O   . ILE A 1 51  ? 62.39522 -11.32655 65.70634 1.000 91.38903  ? 51  ILE B O   1 
ATOM 399  C CB  . ILE A 1 51  ? 60.65027 -9.64361  68.05867 1.000 83.76221  ? 51  ILE B CB  1 
ATOM 400  C CG1 . ILE A 1 51  ? 60.16836 -8.20103  68.29831 1.000 87.93304  ? 51  ILE B CG1 1 
ATOM 401  C CG2 . ILE A 1 51  ? 62.03479 -9.87542  68.59130 1.000 76.23479  ? 51  ILE B CG2 1 
ATOM 402  C CD1 . ILE A 1 51  ? 60.11612 -7.76535  69.75431 1.000 83.26928  ? 51  ILE B CD1 1 
ATOM 403  N N   . LEU A 1 52  ? 60.56567 -12.38683 66.47975 1.000 89.10343  ? 52  LEU B N   1 
ATOM 404  C CA  . LEU A 1 52  ? 61.12229 -13.70129 66.21348 1.000 85.69137  ? 52  LEU B CA  1 
ATOM 405  C C   . LEU A 1 52  ? 61.41381 -13.86725 64.73335 1.000 87.25557  ? 52  LEU B C   1 
ATOM 406  O O   . LEU A 1 52  ? 62.44138 -14.43413 64.34405 1.000 91.81630  ? 52  LEU B O   1 
ATOM 407  C CB  . LEU A 1 52  ? 60.13156 -14.76196 66.66549 1.000 100.23182 ? 52  LEU B CB  1 
ATOM 408  C CG  . LEU A 1 52  ? 59.77748 -14.88789 68.14954 1.000 99.29619  ? 52  LEU B CG  1 
ATOM 409  C CD1 . LEU A 1 52  ? 59.16031 -16.24949 68.44973 1.000 94.74306  ? 52  LEU B CD1 1 
ATOM 410  C CD2 . LEU A 1 52  ? 60.95204 -14.63175 69.04217 1.000 101.34857 ? 52  LEU B CD2 1 
ATOM 411  N N   . TRP A 1 53  ? 60.51508 -13.37254 63.88375 1.000 91.32048  ? 53  TRP B N   1 
ATOM 412  C CA  . TRP A 1 53  ? 60.77100 -13.48407 62.45094 1.000 97.14922  ? 53  TRP B CA  1 
ATOM 413  C C   . TRP A 1 53  ? 61.94735 -12.62281 62.05278 1.000 94.45903  ? 53  TRP B C   1 
ATOM 414  O O   . TRP A 1 53  ? 62.76661 -13.02630 61.21810 1.000 96.38577  ? 53  TRP B O   1 
ATOM 415  C CB  . TRP A 1 53  ? 59.55304 -13.09204 61.60995 1.000 94.36320  ? 53  TRP B CB  1 
ATOM 416  C CG  . TRP A 1 53  ? 58.73410 -14.26187 61.15321 1.000 98.24254  ? 53  TRP B CG  1 
ATOM 417  C CD1 . TRP A 1 53  ? 57.41446 -14.49290 61.42898 1.000 102.49180 ? 53  TRP B CD1 1 
ATOM 418  C CD2 . TRP A 1 53  ? 59.18120 -15.38395 60.37689 1.000 101.92963 ? 53  TRP B CD2 1 
ATOM 419  N NE1 . TRP A 1 53  ? 57.00683 -15.68066 60.86452 1.000 110.55700 ? 53  TRP B NE1 1 
ATOM 420  C CE2 . TRP A 1 53  ? 58.07150 -16.25151 60.21710 1.000 111.10045 ? 53  TRP B CE2 1 
ATOM 421  C CE3 . TRP A 1 53  ? 60.40731 -15.74700 59.81165 1.000 105.85124 ? 53  TRP B CE3 1 
ATOM 422  C CZ2 . TRP A 1 53  ? 58.15332 -17.45512 59.50882 1.000 110.99246 ? 53  TRP B CZ2 1 
ATOM 423  C CZ3 . TRP A 1 53  ? 60.48500 -16.94736 59.10924 1.000 114.04173 ? 53  TRP B CZ3 1 
ATOM 424  C CH2 . TRP A 1 53  ? 59.36619 -17.78458 58.96594 1.000 110.23022 ? 53  TRP B CH2 1 
ATOM 425  N N   . ILE A 1 54  ? 62.02230 -11.41280 62.60021 1.000 87.45583  ? 54  ILE B N   1 
ATOM 426  C CA  . ILE A 1 54  ? 63.14045 -10.55712 62.23840 1.000 88.53610  ? 54  ILE B CA  1 
ATOM 427  C C   . ILE A 1 54  ? 64.45004 -11.26873 62.53713 1.000 93.90672  ? 54  ILE B C   1 
ATOM 428  O O   . ILE A 1 54  ? 65.37885 -11.27545 61.71159 1.000 98.93245  ? 54  ILE B O   1 
ATOM 429  C CB  . ILE A 1 54  ? 63.04989 -9.20401  62.95832 1.000 88.45991  ? 54  ILE B CB  1 
ATOM 430  C CG1 . ILE A 1 54  ? 61.86990 -8.38975  62.41853 1.000 90.59714  ? 54  ILE B CG1 1 
ATOM 431  C CG2 . ILE A 1 54  ? 64.33642 -8.43628  62.75791 1.000 88.40861  ? 54  ILE B CG2 1 
ATOM 432  C CD1 . ILE A 1 54  ? 61.51776 -7.15656  63.25364 1.000 83.56012  ? 54  ILE B CD1 1 
ATOM 433  N N   . ALA A 1 55  ? 64.51928 -11.93798 63.69383 1.000 93.65979  ? 55  ALA B N   1 
ATOM 434  C CA  . ALA A 1 55  ? 65.72762 -12.68184 64.03445 1.000 87.67960  ? 55  ALA B CA  1 
ATOM 435  C C   . ALA A 1 55  ? 65.97784 -13.80968 63.05017 1.000 90.89209  ? 55  ALA B C   1 
ATOM 436  O O   . ALA A 1 55  ? 67.11652 -14.01849 62.61747 1.000 94.86349  ? 55  ALA B O   1 
ATOM 437  C CB  . ALA A 1 55  ? 65.64448 -13.23349 65.44735 1.000 81.06393  ? 55  ALA B CB  1 
ATOM 438  N N   . TYR A 1 56  ? 64.93460 -14.55298 62.68120 1.000 89.78263  ? 56  TYR B N   1 
ATOM 439  C CA  . TYR A 1 56  ? 65.16383 -15.62666 61.72226 1.000 95.99747  ? 56  TYR B CA  1 
ATOM 440  C C   . TYR A 1 56  ? 65.76094 -15.08379 60.43186 1.000 97.14714  ? 56  TYR B C   1 
ATOM 441  O O   . TYR A 1 56  ? 66.75711 -15.61354 59.92368 1.000 96.20549  ? 56  TYR B O   1 
ATOM 442  C CB  . TYR A 1 56  ? 63.87736 -16.38718 61.42042 1.000 99.40566  ? 56  TYR B CB  1 
ATOM 443  C CG  . TYR A 1 56  ? 64.11381 -17.39719 60.32609 1.000 103.05987 ? 56  TYR B CG  1 
ATOM 444  C CD1 . TYR A 1 56  ? 64.66235 -18.65005 60.60840 1.000 105.10304 ? 56  TYR B CD1 1 
ATOM 445  C CD2 . TYR A 1 56  ? 63.81875 -17.09256 59.00555 1.000 99.34252  ? 56  TYR B CD2 1 
ATOM 446  C CE1 . TYR A 1 56  ? 64.89416 -19.56674 59.60432 1.000 100.50390 ? 56  TYR B CE1 1 
ATOM 447  C CE2 . TYR A 1 56  ? 64.04940 -18.00193 58.00677 1.000 105.71076 ? 56  TYR B CE2 1 
ATOM 448  C CZ  . TYR A 1 56  ? 64.58522 -19.22838 58.30897 1.000 101.97572 ? 56  TYR B CZ  1 
ATOM 449  O OH  . TYR A 1 56  ? 64.80403 -20.10355 57.28863 1.000 110.53747 ? 56  TYR B OH  1 
ATOM 450  N N   . HIS A 1 57  ? 65.16995 -14.00945 59.90626 1.000 98.14506  ? 57  HIS B N   1 
ATOM 451  C CA  . HIS A 1 57  ? 65.51399 -13.52061 58.57582 1.000 95.96045  ? 57  HIS B CA  1 
ATOM 452  C C   . HIS A 1 57  ? 66.90521 -12.89712 58.55572 1.000 94.68293  ? 57  HIS B C   1 
ATOM 453  O O   . HIS A 1 57  ? 67.62750 -13.02489 57.55909 1.000 96.21847  ? 57  HIS B O   1 
ATOM 454  C CB  . HIS A 1 57  ? 64.49172 -12.47813 58.10193 1.000 99.01081  ? 57  HIS B CB  1 
ATOM 455  C CG  . HIS A 1 57  ? 63.13733 -13.02452 57.71732 1.000 109.68715 ? 57  HIS B CG  1 
ATOM 456  N ND1 . HIS A 1 57  ? 62.93806 -14.27665 57.16534 1.000 108.75603 ? 57  HIS B ND1 1 
ATOM 457  C CD2 . HIS A 1 57  ? 61.91076 -12.44158 57.77475 1.000 103.48526 ? 57  HIS B CD2 1 
ATOM 458  C CE1 . HIS A 1 57  ? 61.64613 -14.44319 56.92047 1.000 106.13229 ? 57  HIS B CE1 1 
ATOM 459  N NE2 . HIS A 1 57  ? 61.00307 -13.34510 57.28017 1.000 100.64526 ? 57  HIS B NE2 1 
ATOM 460  N N   . PHE A 1 58  ? 67.28386 -12.17965 59.62154 1.000 91.57322  ? 58  PHE B N   1 
ATOM 461  C CA  . PHE A 1 58  ? 68.55179 -11.45854 59.64535 1.000 90.11617  ? 58  PHE B CA  1 
ATOM 462  C C   . PHE A 1 58  ? 69.66096 -12.20346 60.37359 1.000 90.61015  ? 58  PHE B C   1 
ATOM 463  O O   . PHE A 1 58  ? 70.74352 -11.63565 60.55175 1.000 94.65074  ? 58  PHE B O   1 
ATOM 464  C CB  . PHE A 1 58  ? 68.40565 -10.06981 60.28124 1.000 88.35355  ? 58  PHE B CB  1 
ATOM 465  C CG  . PHE A 1 58  ? 67.69457 -9.06084  59.42846 1.000 88.09902  ? 58  PHE B CG  1 
ATOM 466  C CD1 . PHE A 1 58  ? 66.33191 -8.94575  59.46448 1.000 89.03768  ? 58  PHE B CD1 1 
ATOM 467  C CD2 . PHE A 1 58  ? 68.40387 -8.24344  58.56123 1.000 94.87613  ? 58  PHE B CD2 1 
ATOM 468  C CE1 . PHE A 1 58  ? 65.68353 -8.01928  58.67348 1.000 87.35377  ? 58  PHE B CE1 1 
ATOM 469  C CE2 . PHE A 1 58  ? 67.75538 -7.32712  57.76269 1.000 88.78964  ? 58  PHE B CE2 1 
ATOM 470  C CZ  . PHE A 1 58  ? 66.40170 -7.21271  57.82106 1.000 82.41889  ? 58  PHE B CZ  1 
ATOM 471  N N   . LYS A 1 59  ? 69.42444 -13.44945 60.79058 1.000 89.85773  ? 59  LYS B N   1 
ATOM 472  C CA  . LYS A 1 59  ? 70.41464 -14.25568 61.51773 1.000 90.13619  ? 59  LYS B CA  1 
ATOM 473  C C   . LYS A 1 59  ? 70.85339 -13.55904 62.79631 1.000 87.54949  ? 59  LYS B C   1 
ATOM 474  O O   . LYS A 1 59  ? 72.04297 -13.37988 63.05939 1.000 93.36458  ? 59  LYS B O   1 
ATOM 475  C CB  . LYS A 1 59  ? 71.63176 -14.58738 60.65437 1.000 90.71603  ? 59  LYS B CB  1 
ATOM 476  C CG  . LYS A 1 59  ? 72.41902 -15.79023 61.15901 1.000 92.82914  ? 59  LYS B CG  1 
ATOM 477  C CD  . LYS A 1 59  ? 73.24322 -16.44032 60.06259 1.000 99.87255  ? 59  LYS B CD  1 
ATOM 478  C CE  . LYS A 1 59  ? 73.64728 -17.84930 60.43419 1.000 103.61335 ? 59  LYS B CE  1 
ATOM 479  N NZ  . LYS A 1 59  ? 74.01519 -18.61940 59.21780 1.000 109.81034 ? 59  LYS B NZ  1 
ATOM 480  N N   . GLY A 1 60  ? 69.87957 -13.19173 63.60335 1.000 83.61401  ? 60  GLY B N   1 
ATOM 481  C CA  . GLY A 1 60  ? 70.12015 -12.36663 64.76467 1.000 81.21308  ? 60  GLY B CA  1 
ATOM 482  C C   . GLY A 1 60  ? 70.14910 -10.90415 64.39524 1.000 82.23936  ? 60  GLY B C   1 
ATOM 483  O O   . GLY A 1 60  ? 70.34999 -10.53692 63.23137 1.000 82.32026  ? 60  GLY B O   1 
ATOM 484  N N   . ALA A 1 61  ? 69.94701 -10.04707 65.40387 1.000 77.60468  ? 61  ALA B N   1 
ATOM 485  C CA  . ALA A 1 61  ? 69.90075 -8.60723  65.17309 1.000 85.93506  ? 61  ALA B CA  1 
ATOM 486  C C   . ALA A 1 61  ? 70.15294 -7.83076  66.45249 1.000 88.63539  ? 61  ALA B C   1 
ATOM 487  O O   . ALA A 1 61  ? 70.02111 -8.35263  67.56028 1.000 83.63578  ? 61  ALA B O   1 
ATOM 488  C CB  . ALA A 1 61  ? 68.55739 -8.17642  64.58743 1.000 84.64507  ? 61  ALA B CB  1 
ATOM 489  N N   . SER A 1 62  ? 70.53403 -6.57213  66.26067 1.000 88.20250  ? 62  SER B N   1 
ATOM 490  C CA  . SER A 1 62  ? 70.52321 -5.55391  67.28194 1.000 84.22755  ? 62  SER B CA  1 
ATOM 491  C C   . SER A 1 62  ? 69.08619 -5.18445  67.63765 1.000 89.84431  ? 62  SER B C   1 
ATOM 492  O O   . SER A 1 62  ? 68.16314 -5.36806  66.84364 1.000 92.67108  ? 62  SER B O   1 
ATOM 493  C CB  . SER A 1 62  ? 71.32320 -4.36551  66.76440 1.000 88.36400  ? 62  SER B CB  1 
ATOM 494  O OG  . SER A 1 62  ? 70.52626 -3.54412  65.94163 1.000 89.00087  ? 62  SER B OG  1 
ATOM 495  N N   . ILE A 1 63  ? 68.88594 -4.70770  68.86949 1.000 92.70699  ? 63  ILE B N   1 
ATOM 496  C CA  . ILE A 1 63  ? 67.59374 -4.10959  69.20035 1.000 87.52574  ? 63  ILE B CA  1 
ATOM 497  C C   . ILE A 1 63  ? 67.27969 -2.97637  68.23456 1.000 88.31731  ? 63  ILE B C   1 
ATOM 498  O O   . ILE A 1 63  ? 66.14238 -2.83282  67.79346 1.000 93.04267  ? 63  ILE B O   1 
ATOM 499  C CB  . ILE A 1 63  ? 67.53082 -3.64390  70.67495 1.000 87.16515  ? 63  ILE B CB  1 
ATOM 500  C CG1 . ILE A 1 63  ? 67.04258 -4.74493  71.60668 1.000 88.97131  ? 63  ILE B CG1 1 
ATOM 501  C CG2 . ILE A 1 63  ? 66.54946 -2.50659  70.86390 1.000 85.84409  ? 63  ILE B CG2 1 
ATOM 502  C CD1 . ILE A 1 63  ? 67.77176 -6.01351  71.54041 1.000 86.75346  ? 63  ILE B CD1 1 
ATOM 503  N N   . SER A 1 64  ? 68.26782 -2.16357  67.86768 1.000 88.46234  ? 64  SER B N   1 
ATOM 504  C CA  . SER A 1 64  ? 67.92360 -1.05243  66.99281 1.000 91.44046  ? 64  SER B CA  1 
ATOM 505  C C   . SER A 1 64  ? 67.47118 -1.56977  65.63692 1.000 91.20635  ? 64  SER B C   1 
ATOM 506  O O   . SER A 1 64  ? 66.54965 -1.01397  65.02312 1.000 94.39489  ? 64  SER B O   1 
ATOM 507  C CB  . SER A 1 64  ? 69.08908 -0.07831  66.85446 1.000 99.43438  ? 64  SER B CB  1 
ATOM 508  O OG  . SER A 1 64  ? 68.66129 1.08423   66.14391 1.000 108.25951 ? 64  SER B OG  1 
ATOM 509  N N   . GLU A 1 65  ? 68.06466 -2.67608  65.18425 1.000 92.05188  ? 65  GLU B N   1 
ATOM 510  C CA  . GLU A 1 65  ? 67.57331 -3.34336  63.98134 1.000 92.96221  ? 65  GLU B CA  1 
ATOM 511  C C   . GLU A 1 65  ? 66.13885 -3.79946  64.18384 1.000 87.80772  ? 65  GLU B C   1 
ATOM 512  O O   . GLU A 1 65  ? 65.25106 -3.53049  63.35998 1.000 87.53607  ? 65  GLU B O   1 
ATOM 513  C CB  . GLU A 1 65  ? 68.48289 -4.53444  63.64436 1.000 88.79035  ? 65  GLU B CB  1 
ATOM 514  C CG  . GLU A 1 65  ? 69.79840 -4.12188  63.00813 1.000 97.42121  ? 65  GLU B CG  1 
ATOM 515  C CD  . GLU A 1 65  ? 70.67698 -5.28203  62.58559 1.000 106.69910 ? 65  GLU B CD  1 
ATOM 516  O OE1 . GLU A 1 65  ? 70.17817 -6.20860  61.91107 1.000 101.60939 ? 65  GLU B OE1 1 
ATOM 517  O OE2 . GLU A 1 65  ? 71.88443 -5.23582  62.92921 1.000 111.98289 ? 65  GLU B OE2 1 
ATOM 518  N N   . ILE A 1 66  ? 65.89887 -4.45654  65.30803 1.000 87.30412  ? 66  ILE B N   1 
ATOM 519  C CA  . ILE A 1 66  ? 64.59868 -5.02761  65.60913 1.000 87.45479  ? 66  ILE B CA  1 
ATOM 520  C C   . ILE A 1 66  ? 63.52265 -3.95242  65.63520 1.000 86.16854  ? 66  ILE B C   1 
ATOM 521  O O   . ILE A 1 66  ? 62.39136 -4.16836  65.18259 1.000 94.55736  ? 66  ILE B O   1 
ATOM 522  C CB  . ILE A 1 66  ? 64.68718 -5.76167  66.94813 1.000 84.08745  ? 66  ILE B CB  1 
ATOM 523  C CG1 . ILE A 1 66  ? 65.41822 -7.06108  66.74506 1.000 77.79512  ? 66  ILE B CG1 1 
ATOM 524  C CG2 . ILE A 1 66  ? 63.31362 -5.98087  67.53567 1.000 88.64294  ? 66  ILE B CG2 1 
ATOM 525  C CD1 . ILE A 1 66  ? 65.58525 -7.75384  68.00518 1.000 89.23815  ? 66  ILE B CD1 1 
ATOM 526  N N   . ALA A 1 67  ? 63.84835 -2.78055  66.16092 1.000 81.39600  ? 67  ALA B N   1 
ATOM 527  C CA  . ALA A 1 67  ? 62.84898 -1.72986  66.21848 1.000 78.72621  ? 67  ALA B CA  1 
ATOM 528  C C   . ALA A 1 67  ? 62.64622 -1.11038  64.84640 1.000 84.66917  ? 67  ALA B C   1 
ATOM 529  O O   . ALA A 1 67  ? 61.51123 -0.78521  64.46856 1.000 88.48240  ? 67  ALA B O   1 
ATOM 530  C CB  . ALA A 1 67  ? 63.24559 -0.67133  67.23956 1.000 80.08065  ? 67  ALA B CB  1 
ATOM 531  N N   . LYS A 1 68  ? 63.73035 -0.93939  64.07823 1.000 82.46305  ? 68  LYS B N   1 
ATOM 532  C CA  . LYS A 1 68  ? 63.57663 -0.42707  62.72170 1.000 78.07265  ? 68  LYS B CA  1 
ATOM 533  C C   . LYS A 1 68  ? 62.61615 -1.30782  61.92714 1.000 83.40332  ? 68  LYS B C   1 
ATOM 534  O O   . LYS A 1 68  ? 61.54126 -0.86475  61.51500 1.000 82.60581  ? 68  LYS B O   1 
ATOM 535  C CB  . LYS A 1 68  ? 64.93522 -0.34914  62.01911 1.000 76.80531  ? 68  LYS B CB  1 
ATOM 536  C CG  . LYS A 1 68  ? 64.87439 0.29779   60.63082 1.000 75.31687  ? 68  LYS B CG  1 
ATOM 537  C CD  . LYS A 1 68  ? 66.11712 -0.00168  59.76988 1.000 78.01301  ? 68  LYS B CD  1 
ATOM 538  C CE  . LYS A 1 68  ? 66.42778 1.13885   58.77393 1.000 86.98892  ? 68  LYS B CE  1 
ATOM 539  N NZ  . LYS A 1 68  ? 65.20566 1.69786   58.08912 1.000 91.84341  ? 68  LYS B NZ  1 
ATOM 540  N N   . PHE A 1 69  ? 62.98111 -2.57771  61.73114 1.000 84.86678  ? 69  PHE B N   1 
ATOM 541  C CA  . PHE A 1 69  ? 62.20929 -3.48945  60.88992 1.000 74.81308  ? 69  PHE B CA  1 
ATOM 542  C C   . PHE A 1 69  ? 60.89755 -3.91742  61.53304 1.000 82.97555  ? 69  PHE B C   1 
ATOM 543  O O   . PHE A 1 69  ? 60.00831 -4.40099  60.82959 1.000 91.79679  ? 69  PHE B O   1 
ATOM 544  C CB  . PHE A 1 69  ? 63.06169 -4.72620  60.59012 1.000 81.48925  ? 69  PHE B CB  1 
ATOM 545  C CG  . PHE A 1 69  ? 64.24756 -4.45841  59.68936 1.000 86.86301  ? 69  PHE B CG  1 
ATOM 546  C CD1 . PHE A 1 69  ? 64.09242 -4.20669  58.33196 1.000 88.90943  ? 69  PHE B CD1 1 
ATOM 547  C CD2 . PHE A 1 69  ? 65.50208 -4.31415  60.23133 1.000 84.64626  ? 69  PHE B CD2 1 
ATOM 548  C CE1 . PHE A 1 69  ? 65.19101 -3.94423  57.52907 1.000 81.49442  ? 69  PHE B CE1 1 
ATOM 549  C CE2 . PHE A 1 69  ? 66.58550 -4.02797  59.44032 1.000 84.05370  ? 69  PHE B CE2 1 
ATOM 550  C CZ  . PHE A 1 69  ? 66.43479 -3.84370  58.09515 1.000 83.15122  ? 69  PHE B CZ  1 
ATOM 551  N N   . GLY A 1 70  ? 60.76619 -3.78990  62.84417 1.000 76.28950  ? 70  GLY B N   1 
ATOM 552  C CA  . GLY A 1 70  ? 59.54839 -4.13830  63.52766 1.000 73.72446  ? 70  GLY B CA  1 
ATOM 553  C C   . GLY A 1 70  ? 58.59811 -2.98252  63.67366 1.000 84.23338  ? 70  GLY B C   1 
ATOM 554  O O   . GLY A 1 70  ? 57.51747 -3.11960  64.25557 1.000 94.22395  ? 70  GLY B O   1 
ATOM 555  N N   . VAL A 1 71  ? 58.96415 -1.83755  63.12305 1.000 81.04207  ? 71  VAL B N   1 
ATOM 556  C CA  . VAL A 1 71  ? 58.28011 -0.57436  63.36887 1.000 79.85147  ? 71  VAL B CA  1 
ATOM 557  C C   . VAL A 1 71  ? 57.72287 -0.49691  64.78702 1.000 85.63351  ? 71  VAL B C   1 
ATOM 558  O O   . VAL A 1 71  ? 56.51868 -0.31258  65.00614 1.000 86.81119  ? 71  VAL B O   1 
ATOM 559  C CB  . VAL A 1 71  ? 57.21912 -0.28997  62.28662 1.000 77.76475  ? 71  VAL B CB  1 
ATOM 560  C CG1 . VAL A 1 71  ? 57.76996 -0.61550  60.95646 1.000 82.15019  ? 71  VAL B CG1 1 
ATOM 561  C CG2 . VAL A 1 71  ? 56.06662 -1.15218  62.40129 1.000 90.69647  ? 71  VAL B CG2 1 
ATOM 562  N N   . MET A 1 72  ? 58.61723 -0.60020  65.76815 1.000 90.06300  ? 72  MET B N   1 
ATOM 563  C CA  . MET A 1 72  ? 58.27433 -0.31900  67.15196 1.000 90.30409  ? 72  MET B CA  1 
ATOM 564  C C   . MET A 1 72  ? 59.33121 0.60153   67.73504 1.000 87.30686  ? 72  MET B C   1 
ATOM 565  O O   . MET A 1 72  ? 60.34159 0.89503   67.09373 1.000 94.64121  ? 72  MET B O   1 
ATOM 566  C CB  . MET A 1 72  ? 58.14578 -1.61720  67.95700 1.000 83.84482  ? 72  MET B CB  1 
ATOM 567  C CG  . MET A 1 72  ? 59.38224 -2.43195  68.01133 1.000 81.65159  ? 72  MET B CG  1 
ATOM 568  S SD  . MET A 1 72  ? 59.14664 -4.06362  68.73720 1.000 93.16756  ? 72  MET B SD  1 
ATOM 569  C CE  . MET A 1 72  ? 57.92890 -4.76448  67.62525 1.000 90.78935  ? 72  MET B CE  1 
ATOM 570  N N   . HIS A 1 73  ? 59.06805 1.08296   68.94338 1.000 86.92174  ? 73  HIS B N   1 
ATOM 571  C CA  . HIS A 1 73  ? 60.04792 1.87300   69.66707 1.000 87.75657  ? 73  HIS B CA  1 
ATOM 572  C C   . HIS A 1 73  ? 61.14979 0.97126   70.23844 1.000 86.36242  ? 73  HIS B C   1 
ATOM 573  O O   . HIS A 1 73  ? 61.02435 -0.25837  70.30782 1.000 83.10327  ? 73  HIS B O   1 
ATOM 574  C CB  . HIS A 1 73  ? 59.34899 2.66672   70.76354 1.000 90.47641  ? 73  HIS B CB  1 
ATOM 575  C CG  . HIS A 1 73  ? 58.61196 3.85996   70.25068 1.000 92.16737  ? 73  HIS B CG  1 
ATOM 576  N ND1 . HIS A 1 73  ? 57.44246 3.75049   69.53144 1.000 101.75695 ? 73  HIS B ND1 1 
ATOM 577  C CD2 . HIS A 1 73  ? 58.87457 5.18469   70.34231 1.000 101.35024 ? 73  HIS B CD2 1 
ATOM 578  C CE1 . HIS A 1 73  ? 57.01736 4.95577   69.19830 1.000 104.94110 ? 73  HIS B CE1 1 
ATOM 579  N NE2 . HIS A 1 73  ? 57.86916 5.84483   69.67733 1.000 109.30340 ? 73  HIS B NE2 1 
ATOM 580  N N   . VAL A 1 74  ? 62.26716 1.58680   70.61742 1.000 86.54624  ? 74  VAL B N   1 
ATOM 581  C CA  . VAL A 1 74  ? 63.35532 0.77308   71.14522 1.000 91.90219  ? 74  VAL B CA  1 
ATOM 582  C C   . VAL A 1 74  ? 62.91828 0.11788   72.43881 1.000 92.73244  ? 74  VAL B C   1 
ATOM 583  O O   . VAL A 1 74  ? 63.13696 -1.08374  72.66183 1.000 91.01681  ? 74  VAL B O   1 
ATOM 584  C CB  . VAL A 1 74  ? 64.62817 1.61940   71.33659 1.000 97.03472  ? 74  VAL B CB  1 
ATOM 585  C CG1 . VAL A 1 74  ? 65.56693 0.96057   72.32981 1.000 87.93864  ? 74  VAL B CG1 1 
ATOM 586  C CG2 . VAL A 1 74  ? 65.37191 1.74394   70.02333 1.000 98.68643  ? 74  VAL B CG2 1 
ATOM 587  N N   . SER A 1 75  ? 62.28299 0.90714   73.30064 1.000 94.51178  ? 75  SER B N   1 
ATOM 588  C CA  . SER A 1 75  ? 61.82450 0.42978   74.59405 1.000 91.59073  ? 75  SER B CA  1 
ATOM 589  C C   . SER A 1 75  ? 61.03853 -0.85892  74.45229 1.000 91.31955  ? 75  SER B C   1 
ATOM 590  O O   . SER A 1 75  ? 61.37680 -1.88103  75.05827 1.000 92.71213  ? 75  SER B O   1 
ATOM 591  C CB  . SER A 1 75  ? 60.96902 1.51518   75.21115 1.000 89.40604  ? 75  SER B CB  1 
ATOM 592  O OG  . SER A 1 75  ? 61.53606 2.75942   74.83673 1.000 103.06156 ? 75  SER B OG  1 
ATOM 593  N N   . THR A 1 76  ? 59.98176 -0.81954  73.65239 1.000 89.57669  ? 76  THR B N   1 
ATOM 594  C CA  . THR A 1 76  ? 59.15962 -1.99713  73.44950 1.000 90.65085  ? 76  THR B CA  1 
ATOM 595  C C   . THR A 1 76  ? 60.00279 -3.16491  72.95425 1.000 90.43666  ? 76  THR B C   1 
ATOM 596  O O   . THR A 1 76  ? 59.80775 -4.30757  73.38390 1.000 92.18349  ? 76  THR B O   1 
ATOM 597  C CB  . THR A 1 76  ? 58.07105 -1.65632  72.44555 1.000 89.14030  ? 76  THR B CB  1 
ATOM 598  O OG1 . THR A 1 76  ? 58.70743 -1.33867  71.20591 1.000 105.65900 ? 76  THR B OG1 1 
ATOM 599  C CG2 . THR A 1 76  ? 57.30820 -0.40565  72.89103 1.000 81.37732  ? 76  THR B CG2 1 
ATOM 600  N N   . ALA A 1 77  ? 60.95744 -2.89259  72.05733 1.000 90.86521  ? 77  ALA B N   1 
ATOM 601  C CA  . ALA A 1 77  ? 61.76651 -3.96569  71.48933 1.000 90.91922  ? 77  ALA B CA  1 
ATOM 602  C C   . ALA A 1 77  ? 62.60037 -4.63847  72.56528 1.000 91.57907  ? 77  ALA B C   1 
ATOM 603  O O   . ALA A 1 77  ? 62.69138 -5.86982  72.61773 1.000 87.45541  ? 77  ALA B O   1 
ATOM 604  C CB  . ALA A 1 77  ? 62.64573 -3.42075  70.37204 1.000 83.95420  ? 77  ALA B CB  1 
ATOM 605  N N   . PHE A 1 78  ? 63.14426 -3.84868  73.48988 1.000 91.64958  ? 78  PHE B N   1 
ATOM 606  C CA  . PHE A 1 78  ? 63.86012 -4.45767  74.59926 1.000 96.58056  ? 78  PHE B CA  1 
ATOM 607  C C   . PHE A 1 78  ? 62.91933 -5.23091  75.52037 1.000 102.13403 ? 78  PHE B C   1 
ATOM 608  O O   . PHE A 1 78  ? 63.21475 -6.37413  75.89438 1.000 97.97097  ? 78  PHE B O   1 
ATOM 609  C CB  . PHE A 1 78  ? 64.65701 -3.40329  75.35966 1.000 97.63022  ? 78  PHE B CB  1 
ATOM 610  C CG  . PHE A 1 78  ? 65.59357 -3.99366  76.36898 1.000 100.29862 ? 78  PHE B CG  1 
ATOM 611  C CD1 . PHE A 1 78  ? 66.66917 -4.75044  75.95980 1.000 96.30153  ? 78  PHE B CD1 1 
ATOM 612  C CD2 . PHE A 1 78  ? 65.44039 -3.74042  77.71070 1.000 108.40118 ? 78  PHE B CD2 1 
ATOM 613  C CE1 . PHE A 1 78  ? 67.52769 -5.29662  76.86514 1.000 97.50214  ? 78  PHE B CE1 1 
ATOM 614  C CE2 . PHE A 1 78  ? 66.31732 -4.27676  78.62786 1.000 111.76440 ? 78  PHE B CE2 1 
ATOM 615  C CZ  . PHE A 1 78  ? 67.36279 -5.05721  78.19847 1.000 105.09709 ? 78  PHE B CZ  1 
ATOM 616  N N   . ASN A 1 79  ? 61.76833 -4.64193  75.86239 1.000 102.56983 ? 79  ASN B N   1 
ATOM 617  C CA  . ASN A 1 79  ? 60.85872 -5.25826  76.82915 1.000 101.83303 ? 79  ASN B CA  1 
ATOM 618  C C   . ASN A 1 79  ? 60.35310 -6.60348  76.32439 1.000 96.78960  ? 79  ASN B C   1 
ATOM 619  O O   . ASN A 1 79  ? 60.40083 -7.61680  77.03596 1.000 101.31773 ? 79  ASN B O   1 
ATOM 620  C CB  . ASN A 1 79  ? 59.68445 -4.31017  77.12333 1.000 103.19778 ? 79  ASN B CB  1 
ATOM 621  C CG  . ASN A 1 79  ? 58.66111 -4.90078  78.11825 1.000 123.34782 ? 79  ASN B CG  1 
ATOM 622  O OD1 . ASN A 1 79  ? 58.97958 -5.78031  78.93876 1.000 123.98782 ? 79  ASN B OD1 1 
ATOM 623  N ND2 . ASN A 1 79  ? 57.42601 -4.39713  78.05217 1.000 115.46948 ? 79  ASN B ND2 1 
ATOM 624  N N   . PHE A 1 80  ? 59.85311 -6.63043  75.09689 1.000 92.24984  ? 80  PHE B N   1 
ATOM 625  C CA  . PHE A 1 80  ? 59.27017 -7.86198  74.58090 1.000 98.78501  ? 80  PHE B CA  1 
ATOM 626  C C   . PHE A 1 80  ? 60.35487 -8.87019  74.23350 1.000 96.59585  ? 80  PHE B C   1 
ATOM 627  O O   . PHE A 1 80  ? 60.13935 -10.09056 74.32436 1.000 89.94464  ? 80  PHE B O   1 
ATOM 628  C CB  . PHE A 1 80  ? 58.39208 -7.55630  73.36312 1.000 98.73662  ? 80  PHE B CB  1 
ATOM 629  C CG  . PHE A 1 80  ? 57.03006 -6.95731  73.70763 1.000 100.58498 ? 80  PHE B CG  1 
ATOM 630  C CD1 . PHE A 1 80  ? 55.93166 -7.75826  73.96041 1.000 100.86608 ? 80  PHE B CD1 1 
ATOM 631  C CD2 . PHE A 1 80  ? 56.87327 -5.58799  73.80451 1.000 101.64518 ? 80  PHE B CD2 1 
ATOM 632  C CE1 . PHE A 1 80  ? 54.70583 -7.19906  74.27177 1.000 104.96448 ? 80  PHE B CE1 1 
ATOM 633  C CE2 . PHE A 1 80  ? 55.66115 -5.03288  74.12377 1.000 99.92513  ? 80  PHE B CE2 1 
ATOM 634  C CZ  . PHE A 1 80  ? 54.57527 -5.83164  74.35594 1.000 105.33216 ? 80  PHE B CZ  1 
ATOM 635  N N   . SER A 1 81  ? 61.55036 -8.37711  73.89163 1.000 99.72862  ? 81  SER B N   1 
ATOM 636  C CA  . SER A 1 81  ? 62.67842 -9.26697  73.68664 1.000 95.26786  ? 81  SER B CA  1 
ATOM 637  C C   . SER A 1 81  ? 63.00913 -10.00069 74.97647 1.000 97.75414  ? 81  SER B C   1 
ATOM 638  O O   . SER A 1 81  ? 63.24251 -11.21613 74.98119 1.000 94.12787  ? 81  SER B O   1 
ATOM 639  C CB  . SER A 1 81  ? 63.86433 -8.42747  73.21703 1.000 98.06406  ? 81  SER B CB  1 
ATOM 640  O OG  . SER A 1 81  ? 63.57164 -7.72376  72.01220 1.000 95.80986  ? 81  SER B OG  1 
ATOM 641  N N   . LYS A 1 82  ? 63.01194 -9.26230  76.08904 1.000 97.18941  ? 82  LYS B N   1 
ATOM 642  C CA  . LYS A 1 82  ? 63.26586 -9.85044  77.39948 1.000 95.99927  ? 82  LYS B CA  1 
ATOM 643  C C   . LYS A 1 82  ? 62.20159 -10.87963 77.74478 1.000 98.86588  ? 82  LYS B C   1 
ATOM 644  O O   . LYS A 1 82  ? 62.51760 -12.00277 78.15020 1.000 102.95304 ? 82  LYS B O   1 
ATOM 645  C CB  . LYS A 1 82  ? 63.31721 -8.73436  78.44617 1.000 94.21830  ? 82  LYS B CB  1 
ATOM 646  C CG  . LYS A 1 82  ? 64.22310 -8.95687  79.66921 1.000 99.08988  ? 82  LYS B CG  1 
ATOM 647  C CD  . LYS A 1 82  ? 65.69259 -8.65704  79.36136 1.000 101.95660 ? 82  LYS B CD  1 
ATOM 648  C CE  . LYS A 1 82  ? 66.61884 -8.79601  80.57448 1.000 105.68843 ? 82  LYS B CE  1 
ATOM 649  N NZ  . LYS A 1 82  ? 66.27664 -7.87184  81.69205 1.000 106.34583 ? 82  LYS B NZ  1 
ATOM 650  N N   . LYS A 1 83  ? 60.93074 -10.51150 77.57684 1.000 97.64796  ? 83  LYS B N   1 
ATOM 651  C CA  . LYS A 1 83  ? 59.84283 -11.45974 77.80228 1.000 96.81281  ? 83  LYS B CA  1 
ATOM 652  C C   . LYS A 1 83  ? 60.05719 -12.73851 77.01173 1.000 98.85663  ? 83  LYS B C   1 
ATOM 653  O O   . LYS A 1 83  ? 59.71037 -13.82891 77.47283 1.000 105.07899 ? 83  LYS B O   1 
ATOM 654  C CB  . LYS A 1 83  ? 58.50012 -10.83362 77.41937 1.000 103.05278 ? 83  LYS B CB  1 
ATOM 655  C CG  . LYS A 1 83  ? 57.95478 -9.83686  78.42800 1.000 107.05761 ? 83  LYS B CG  1 
ATOM 656  C CD  . LYS A 1 83  ? 56.68682 -9.16085  77.92873 1.000 108.12166 ? 83  LYS B CD  1 
ATOM 657  C CE  . LYS A 1 83  ? 56.12328 -8.22044  78.98576 1.000 116.71818 ? 83  LYS B CE  1 
ATOM 658  N NZ  . LYS A 1 83  ? 55.04203 -7.35906  78.43082 1.000 120.70104 ? 83  LYS B NZ  1 
ATOM 659  N N   . LEU A 1 84  ? 60.61898 -12.62965 75.81343 1.000 97.59436  ? 84  LEU B N   1 
ATOM 660  C CA  . LEU A 1 84  ? 60.86893 -13.83828 75.03759 1.000 100.00981 ? 84  LEU B CA  1 
ATOM 661  C C   . LEU A 1 84  ? 62.04795 -14.61213 75.58487 1.000 103.47961 ? 84  LEU B C   1 
ATOM 662  O O   . LEU A 1 84  ? 62.08481 -15.84383 75.50469 1.000 106.73715 ? 84  LEU B O   1 
ATOM 663  C CB  . LEU A 1 84  ? 61.12357 -13.48992 73.58491 1.000 102.65623 ? 84  LEU B CB  1 
ATOM 664  C CG  . LEU A 1 84  ? 59.91549 -12.90101 72.90388 1.000 98.79100  ? 84  LEU B CG  1 
ATOM 665  C CD1 . LEU A 1 84  ? 60.36717 -12.18550 71.68055 1.000 96.99328  ? 84  LEU B CD1 1 
ATOM 666  C CD2 . LEU A 1 84  ? 59.02547 -14.04807 72.52906 1.000 105.27373 ? 84  LEU B CD2 1 
ATOM 667  N N   . GLU A 1 85  ? 63.05442 -13.90050 76.08140 1.000 107.02903 ? 85  GLU B N   1 
ATOM 668  C CA  . GLU A 1 85  ? 64.17463 -14.58260 76.71429 1.000 109.29184 ? 85  GLU B CA  1 
ATOM 669  C C   . GLU A 1 85  ? 63.67690 -15.42146 77.88066 1.000 108.79227 ? 85  GLU B C   1 
ATOM 670  O O   . GLU A 1 85  ? 64.09055 -16.57409 78.05192 1.000 110.37446 ? 85  GLU B O   1 
ATOM 671  C CB  . GLU A 1 85  ? 65.22447 -13.56694 77.17274 1.000 103.10140 ? 85  GLU B CB  1 
ATOM 672  C CG  . GLU A 1 85  ? 66.48474 -14.19852 77.71881 1.000 106.60507 ? 85  GLU B CG  1 
ATOM 673  C CD  . GLU A 1 85  ? 67.41323 -13.20579 78.40738 1.000 111.27316 ? 85  GLU B CD  1 
ATOM 674  O OE1 . GLU A 1 85  ? 66.92098 -12.17316 78.90317 1.000 107.86826 ? 85  GLU B OE1 1 
ATOM 675  O OE2 . GLU A 1 85  ? 68.63933 -13.46619 78.45035 1.000 108.36403 ? 85  GLU B OE2 1 
ATOM 676  N N   . GLU A 1 86  ? 62.75401 -14.86516 78.67054 1.000 106.15320 ? 86  GLU B N   1 
ATOM 677  C CA  . GLU A 1 86  ? 62.15865 -15.61803 79.76823 1.000 111.32711 ? 86  GLU B CA  1 
ATOM 678  C C   . GLU A 1 86  ? 61.51851 -16.90858 79.27303 1.000 111.15005 ? 86  GLU B C   1 
ATOM 679  O O   . GLU A 1 86  ? 61.62050 -17.95362 79.92818 1.000 111.47944 ? 86  GLU B O   1 
ATOM 680  C CB  . GLU A 1 86  ? 61.11761 -14.76158 80.49118 1.000 111.89190 ? 86  GLU B CB  1 
ATOM 681  C CG  . GLU A 1 86  ? 61.59115 -13.38790 80.94850 1.000 117.10685 ? 86  GLU B CG  1 
ATOM 682  C CD  . GLU A 1 86  ? 62.71384 -13.42620 81.98165 1.000 133.88508 ? 86  GLU B CD  1 
ATOM 683  O OE1 . GLU A 1 86  ? 63.13608 -12.33614 82.42176 1.000 135.36508 ? 86  GLU B OE1 1 
ATOM 684  O OE2 . GLU A 1 86  ? 63.15969 -14.52999 82.36849 1.000 138.24043 ? 86  GLU B OE2 1 
ATOM 685  N N   . LYS A 1 87  ? 60.86557 -16.85718 78.10928 1.000 104.57061 ? 87  LYS B N   1 
ATOM 686  C CA  . LYS A 1 87  ? 60.19575 -18.02243 77.54957 1.000 107.44053 ? 87  LYS B CA  1 
ATOM 687  C C   . LYS A 1 87  ? 61.16322 -18.99223 76.87922 1.000 111.20452 ? 87  LYS B C   1 
ATOM 688  O O   . LYS A 1 87  ? 60.71056 -19.97655 76.28022 1.000 108.69603 ? 87  LYS B O   1 
ATOM 689  C CB  . LYS A 1 87  ? 59.14329 -17.56868 76.53879 1.000 106.47338 ? 87  LYS B CB  1 
ATOM 690  C CG  . LYS A 1 87  ? 58.13423 -16.58042 77.11510 1.000 108.66452 ? 87  LYS B CG  1 
ATOM 691  C CD  . LYS A 1 87  ? 57.01531 -16.20501 76.12662 1.000 110.13651 ? 87  LYS B CD  1 
ATOM 692  C CE  . LYS A 1 87  ? 56.05854 -15.17893 76.73925 1.000 110.43078 ? 87  LYS B CE  1 
ATOM 693  N NZ  . LYS A 1 87  ? 54.79237 -15.04361 75.98317 1.000 110.60188 ? 87  LYS B NZ  1 
ATOM 694  N N   . GLY A 1 88  ? 62.47100 -18.73179 76.94951 1.000 105.24082 ? 88  GLY B N   1 
ATOM 695  C CA  . GLY A 1 88  ? 63.45858 -19.56710 76.31324 1.000 98.58330  ? 88  GLY B CA  1 
ATOM 696  C C   . GLY A 1 88  ? 63.40181 -19.57381 74.81034 1.000 98.23303  ? 88  GLY B C   1 
ATOM 697  O O   . GLY A 1 88  ? 63.85981 -20.53807 74.19481 1.000 102.30757 ? 88  GLY B O   1 
ATOM 698  N N   . LEU A 1 89  ? 62.85837 -18.52781 74.19988 1.000 107.84173 ? 89  LEU B N   1 
ATOM 699  C CA  . LEU A 1 89  ? 62.73883 -18.48963 72.74926 1.000 105.28762 ? 89  LEU B CA  1 
ATOM 700  C C   . LEU A 1 89  ? 63.98891 -17.92130 72.10453 1.000 105.81421 ? 89  LEU B C   1 
ATOM 701  O O   . LEU A 1 89  ? 64.44459 -18.43149 71.07576 1.000 105.90329 ? 89  LEU B O   1 
ATOM 702  C CB  . LEU A 1 89  ? 61.51174 -17.67808 72.36857 1.000 103.14124 ? 89  LEU B CB  1 
ATOM 703  C CG  . LEU A 1 89  ? 60.25511 -18.24657 73.01609 1.000 99.01622  ? 89  LEU B CG  1 
ATOM 704  C CD1 . LEU A 1 89  ? 59.02160 -17.72439 72.35009 1.000 100.18986 ? 89  LEU B CD1 1 
ATOM 705  C CD2 . LEU A 1 89  ? 60.30330 -19.74014 72.81745 1.000 106.85726 ? 89  LEU B CD2 1 
ATOM 706  N N   . LEU A 1 90  ? 64.58005 -16.89763 72.71607 1.000 109.45569 ? 90  LEU B N   1 
ATOM 707  C CA  . LEU A 1 90  ? 65.75354 -16.21967 72.18271 1.000 112.53625 ? 90  LEU B CA  1 
ATOM 708  C C   . LEU A 1 90  ? 66.81136 -16.03068 73.26892 1.000 110.35630 ? 90  LEU B C   1 
ATOM 709  O O   . LEU A 1 90  ? 66.54344 -16.21430 74.45885 1.000 112.14679 ? 90  LEU B O   1 
ATOM 710  C CB  . LEU A 1 90  ? 65.33870 -14.88223 71.55155 1.000 109.45641 ? 90  LEU B CB  1 
ATOM 711  C CG  . LEU A 1 90  ? 64.58695 -13.81417 72.35762 1.000 109.88140 ? 90  LEU B CG  1 
ATOM 712  C CD1 . LEU A 1 90  ? 65.40517 -13.17567 73.49291 1.000 112.72253 ? 90  LEU B CD1 1 
ATOM 713  C CD2 . LEU A 1 90  ? 64.04132 -12.75149 71.39608 1.000 100.26656 ? 90  LEU B CD2 1 
ATOM 714  N N   . SER A 1 91  ? 68.02552 -15.67811 72.83704 1.000 108.50584 ? 91  SER B N   1 
ATOM 715  C CA  . SER A 1 91  ? 69.17757 -15.43091 73.69848 1.000 107.39889 ? 91  SER B CA  1 
ATOM 716  C C   . SER A 1 91  ? 69.67531 -14.00034 73.52750 1.000 109.43567 ? 91  SER B C   1 
ATOM 717  O O   . SER A 1 91  ? 69.43989 -13.35713 72.49658 1.000 111.99043 ? 91  SER B O   1 
ATOM 718  C CB  . SER A 1 91  ? 70.32131 -16.40724 73.38791 1.000 103.25196 ? 91  SER B CB  1 
ATOM 719  O OG  . SER A 1 91  ? 70.76940 -16.28772 72.04384 1.000 102.74994 ? 91  SER B OG  1 
ATOM 720  N N   . PHE A 1 92  ? 70.39145 -13.52021 74.55065 1.000 106.45508 ? 92  PHE B N   1 
ATOM 721  C CA  . PHE A 1 92  ? 70.87230 -12.14423 74.63299 1.000 104.33375 ? 92  PHE B CA  1 
ATOM 722  C C   . PHE A 1 92  ? 72.39626 -12.10023 74.59164 1.000 113.24757 ? 92  PHE B C   1 
ATOM 723  O O   . PHE A 1 92  ? 73.06685 -13.04785 75.00485 1.000 117.64582 ? 92  PHE B O   1 
ATOM 724  C CB  . PHE A 1 92  ? 70.39100 -11.50408 75.92567 1.000 104.31166 ? 92  PHE B CB  1 
ATOM 725  C CG  . PHE A 1 92  ? 69.16001 -10.67611 75.76962 1.000 111.38807 ? 92  PHE B CG  1 
ATOM 726  C CD1 . PHE A 1 92  ? 67.96877 -11.25871 75.39328 1.000 109.50856 ? 92  PHE B CD1 1 
ATOM 727  C CD2 . PHE A 1 92  ? 69.16503 -9.33336  76.08320 1.000 111.95295 ? 92  PHE B CD2 1 
ATOM 728  C CE1 . PHE A 1 92  ? 66.83690 -10.50581 75.27998 1.000 101.25605 ? 92  PHE B CE1 1 
ATOM 729  C CE2 . PHE A 1 92  ? 68.02003 -8.58780  75.97429 1.000 97.83211  ? 92  PHE B CE2 1 
ATOM 730  C CZ  . PHE A 1 92  ? 66.86406 -9.17753  75.57532 1.000 94.70870  ? 92  PHE B CZ  1 
ATOM 731  N N   . SER A 1 93  ? 72.94230 -11.00015 74.08094 1.000 114.03600 ? 93  SER B N   1 
ATOM 732  C CA  . SER A 1 93  ? 74.37907 -10.78528 74.13866 1.000 110.44722 ? 93  SER B CA  1 
ATOM 733  C C   . SER A 1 93  ? 74.77059 -10.26520 75.51990 1.000 124.17980 ? 93  SER B C   1 
ATOM 734  O O   . SER A 1 93  ? 73.92250 -9.83306  76.30520 1.000 129.77032 ? 93  SER B O   1 
ATOM 735  C CB  . SER A 1 93  ? 74.80643 -9.80485  73.05044 1.000 108.35054 ? 93  SER B CB  1 
ATOM 736  O OG  . SER A 1 93  ? 74.63419 -8.46203  73.48711 1.000 109.65012 ? 93  SER B OG  1 
ATOM 737  N N   . LYS A 1 94  ? 76.07520 -10.33164 75.82656 1.000 128.93512 ? 94  LYS B N   1 
ATOM 738  C CA  . LYS A 1 94  ? 76.54765 -9.93146  77.15550 1.000 127.99512 ? 94  LYS B CA  1 
ATOM 739  C C   . LYS A 1 94  ? 76.44932 -8.42582  77.36512 1.000 132.48940 ? 94  LYS B C   1 
ATOM 740  O O   . LYS A 1 94  ? 76.13308 -7.96900  78.47072 1.000 137.20170 ? 94  LYS B O   1 
ATOM 741  C CB  . LYS A 1 94  ? 77.99286 -10.38218 77.38332 1.000 128.43631 ? 94  LYS B CB  1 
ATOM 742  C CG  . LYS A 1 94  ? 78.62795 -9.82059  78.67857 1.000 126.99292 ? 94  LYS B CG  1 
ATOM 743  C CD  . LYS A 1 94  ? 80.06320 -10.29977 78.90586 1.000 124.41451 ? 94  LYS B CD  1 
ATOM 744  C CE  . LYS A 1 94  ? 80.63335 -9.74628  80.20188 1.000 127.02007 ? 94  LYS B CE  1 
ATOM 745  N NZ  . LYS A 1 94  ? 82.04703 -10.17658 80.39922 1.000 119.17290 ? 94  LYS B NZ  1 
ATOM 746  N N   . LYS A 1 95  ? 76.75148 -7.63650  76.33678 1.000 135.20703 ? 95  LYS B N   1 
ATOM 747  C CA  . LYS A 1 95  ? 76.78107 -6.19159  76.51053 1.000 135.60990 ? 95  LYS B CA  1 
ATOM 748  C C   . LYS A 1 95  ? 75.35959 -5.64515  76.61925 1.000 133.45990 ? 95  LYS B C   1 
ATOM 749  O O   . LYS A 1 95  ? 74.52049 -5.88510  75.74623 1.000 131.80951 ? 95  LYS B O   1 
ATOM 750  C CB  . LYS A 1 95  ? 77.54228 -5.53144  75.35679 1.000 131.69990 ? 95  LYS B CB  1 
ATOM 751  C CG  . LYS A 1 95  ? 76.94264 -5.76475  73.96127 1.000 125.83162 ? 95  LYS B CG  1 
ATOM 752  C CD  . LYS A 1 95  ? 77.49047 -4.80531  72.91193 1.000 120.32348 ? 95  LYS B CD  1 
ATOM 753  C CE  . LYS A 1 95  ? 77.32239 -5.35952  71.50453 1.000 113.39033 ? 95  LYS B CE  1 
ATOM 754  N NZ  . LYS A 1 95  ? 75.96651 -5.95856  71.31409 1.000 106.22354 ? 95  LYS B NZ  1 
ATOM 755  N N   . GLN A 1 96  ? 75.07281 -4.94548  77.72190 1.000 132.05968 ? 96  GLN B N   1 
ATOM 756  C CA  . GLN A 1 96  ? 73.84924 -4.15670  77.85407 1.000 134.80474 ? 96  GLN B CA  1 
ATOM 757  C C   . GLN A 1 96  ? 74.15305 -2.66736  77.94364 1.000 128.26861 ? 96  GLN B C   1 
ATOM 758  O O   . GLN A 1 96  ? 73.31383 -1.89711  78.43182 1.000 127.51474 ? 96  GLN B O   1 
ATOM 759  C CB  . GLN A 1 96  ? 73.00861 -4.60548  79.06004 1.000 137.72474 ? 96  GLN B CB  1 
ATOM 760  C CG  . GLN A 1 96  ? 71.85112 -5.57685  78.72697 1.000 132.58474 ? 96  GLN B CG  1 
ATOM 761  C CD  . GLN A 1 96  ? 72.25698 -7.04952  78.63522 1.000 133.23707 ? 96  GLN B CD  1 
ATOM 762  O OE1 . GLN A 1 96  ? 73.39005 -7.37755  78.27020 1.000 134.29474 ? 96  GLN B OE1 1 
ATOM 763  N NE2 . GLN A 1 96  ? 71.31475 -7.94533  78.95639 1.000 120.79578 ? 96  GLN B NE2 1 
ATOM 764  N N   . ASP A 1 97  ? 75.34089 -2.25792  77.46965 1.000 130.67671 ? 97  ASP B N   1 
ATOM 765  C CA  . ASP A 1 97  ? 75.76980 -0.86428  77.57701 1.000 130.25671 ? 97  ASP B CA  1 
ATOM 766  C C   . ASP A 1 97  ? 74.66572 0.06683   77.11423 1.000 130.99671 ? 97  ASP B C   1 
ATOM 767  O O   . ASP A 1 97  ? 74.18485 0.92639   77.86612 1.000 129.58695 ? 97  ASP B O   1 
ATOM 768  C CB  . ASP A 1 97  ? 77.00618 -0.59507  76.71798 1.000 117.54279 ? 97  ASP B CB  1 
ATOM 769  C CG  . ASP A 1 97  ? 76.95062 -1.29951  75.35957 1.000 122.96390 ? 97  ASP B CG  1 
ATOM 770  O OD1 . ASP A 1 97  ? 76.30033 -2.36321  75.26600 1.000 132.62435 ? 97  ASP B OD1 1 
ATOM 771  O OD2 . ASP A 1 97  ? 77.49792 -0.74238  74.37798 1.000 114.68774 ? 97  ASP B OD2 1 
ATOM 772  N N   . ASP A 1 98  ? 74.27257 -0.09722  75.86069 1.000 128.25827 ? 98  ASP B N   1 
ATOM 773  C CA  . ASP A 1 98  ? 73.14493 0.57278   75.26528 1.000 119.99625 ? 98  ASP B CA  1 
ATOM 774  C C   . ASP A 1 98  ? 72.16845 -0.51164  74.86071 1.000 121.06693 ? 98  ASP B C   1 
ATOM 775  O O   . ASP A 1 98  ? 72.54331 -1.44920  74.14568 1.000 115.03454 ? 98  ASP B O   1 
ATOM 776  C CB  . ASP A 1 98  ? 73.58669 1.40102   74.06986 1.000 115.10785 ? 98  ASP B CB  1 
ATOM 777  C CG  . ASP A 1 98  ? 72.67382 2.55994   73.81346 1.000 129.84441 ? 98  ASP B CG  1 
ATOM 778  O OD1 . ASP A 1 98  ? 71.68046 2.68242   74.55100 1.000 140.27472 ? 98  ASP B OD1 1 
ATOM 779  O OD2 . ASP A 1 98  ? 72.95801 3.36753   72.89961 1.000 135.85949 ? 98  ASP B OD2 1 
ATOM 780  N N   . LYS A 1 99  ? 70.93703 -0.40709  75.36724 1.000 120.53379 ? 99  LYS B N   1 
ATOM 781  C CA  . LYS A 1 99  ? 69.86849 -1.30031  74.92956 1.000 108.41680 ? 99  LYS B CA  1 
ATOM 782  C C   . LYS A 1 99  ? 69.90079 -1.50228  73.41931 1.000 106.83997 ? 99  LYS B C   1 
ATOM 783  O O   . LYS A 1 99  ? 69.71331 -2.62185  72.92977 1.000 102.64628 ? 99  LYS B O   1 
ATOM 784  C CB  . LYS A 1 99  ? 68.50996 -0.73922  75.35392 1.000 108.89558 ? 99  LYS B CB  1 
ATOM 785  C CG  . LYS A 1 99  ? 68.28501 -0.70498  76.85099 1.000 114.91324 ? 99  LYS B CG  1 
ATOM 786  C CD  . LYS A 1 99  ? 66.89109 -0.21132  77.20789 1.000 114.37420 ? 99  LYS B CD  1 
ATOM 787  C CE  . LYS A 1 99  ? 66.72784 -0.18989  78.71469 1.000 114.52104 ? 99  LYS B CE  1 
ATOM 788  N NZ  . LYS A 1 99  ? 65.38336 0.28360   79.11526 1.000 108.12717 ? 99  LYS B NZ  1 
ATOM 789  N N   . ARG A 1 100 ? 70.17619 -0.43010  72.67116 1.000 107.25170 ? 100 ARG B N   1 
ATOM 790  C CA  . ARG A 1 100 ? 70.10142 -0.46494  71.21453 1.000 103.31404 ? 100 ARG B CA  1 
ATOM 791  C C   . ARG A 1 100 ? 71.06609 -1.48252  70.63445 1.000 105.02781 ? 100 ARG B C   1 
ATOM 792  O O   . ARG A 1 100 ? 70.74344 -2.18242  69.66666 1.000 97.04346  ? 100 ARG B O   1 
ATOM 793  C CB  . ARG A 1 100 ? 70.41894 0.92202   70.67856 1.000 108.38361 ? 100 ARG B CB  1 
ATOM 794  C CG  . ARG A 1 100 ? 69.95110 1.99935   71.62135 1.000 119.51871 ? 100 ARG B CG  1 
ATOM 795  C CD  . ARG A 1 100 ? 69.78528 3.32658   70.92241 1.000 129.51711 ? 100 ARG B CD  1 
ATOM 796  N NE  . ARG A 1 100 ? 70.75832 3.46398   69.85021 1.000 135.57305 ? 100 ARG B NE  1 
ATOM 797  C CZ  . ARG A 1 100 ? 70.45437 3.43430   68.55788 1.000 137.34765 ? 100 ARG B CZ  1 
ATOM 798  N NH1 . ARG A 1 100 ? 71.42305 3.56839   67.65113 1.000 140.55478 ? 100 ARG B NH1 1 
ATOM 799  N NH2 . ARG A 1 100 ? 69.18811 3.25184   68.17899 1.000 121.01765 ? 100 ARG B NH2 1 
ATOM 800  N N   . ASN A 1 101 ? 72.26599 -1.55448  71.20001 1.000 105.40171 ? 101 ASN B N   1 
ATOM 801  C CA  . ASN A 1 101 ? 73.31999 -2.40551  70.68829 1.000 95.46420  ? 101 ASN B CA  1 
ATOM 802  C C   . ASN A 1 101 ? 73.23889 -3.83089  71.20637 1.000 96.14352  ? 101 ASN B C   1 
ATOM 803  O O   . ASN A 1 101 ? 74.00191 -4.68174  70.74011 1.000 98.49910  ? 101 ASN B O   1 
ATOM 804  C CB  . ASN A 1 101 ? 74.66488 -1.75663  71.01582 1.000 99.71611  ? 101 ASN B CB  1 
ATOM 805  C CG  . ASN A 1 101 ? 74.73564 -0.30521  70.55676 1.000 97.60497  ? 101 ASN B CG  1 
ATOM 806  O OD1 . ASN A 1 101 ? 73.94529 0.12744   69.73077 1.000 103.40438 ? 101 ASN B OD1 1 
ATOM 807  N ND2 . ASN A 1 101 ? 75.63534 0.46093   71.13718 1.000 100.20844 ? 101 ASN B ND2 1 
ATOM 808  N N   . THR A 1 102 ? 72.34028 -4.12261  72.14055 1.000 97.90099  ? 102 THR B N   1 
ATOM 809  C CA  . THR A 1 102 ? 72.16356 -5.50576  72.55667 1.000 93.54014  ? 102 THR B CA  1 
ATOM 810  C C   . THR A 1 102 ? 71.83859 -6.36310  71.34817 1.000 90.31146  ? 102 THR B C   1 
ATOM 811  O O   . THR A 1 102 ? 71.07618 -5.95966  70.46743 1.000 96.01290  ? 102 THR B O   1 
ATOM 812  C CB  . THR A 1 102 ? 71.05534 -5.62700  73.59429 1.000 94.46342  ? 102 THR B CB  1 
ATOM 813  O OG1 . THR A 1 102 ? 71.16689 -4.56195  74.54681 1.000 106.74887 ? 102 THR B OG1 1 
ATOM 814  C CG2 . THR A 1 102 ? 71.14099 -6.95446  74.29932 1.000 95.57286  ? 102 THR B CG2 1 
ATOM 815  N N   . TYR A 1 103 ? 72.45413 -7.53372  71.28255 1.000 91.43795  ? 103 TYR B N   1 
ATOM 816  C CA  . TYR A 1 103 ? 72.32438 -8.41321  70.12944 1.000 92.31285  ? 103 TYR B CA  1 
ATOM 817  C C   . TYR A 1 103 ? 71.49878 -9.61485  70.53255 1.000 92.03090  ? 103 TYR B C   1 
ATOM 818  O O   . TYR A 1 103 ? 71.74863 -10.22417 71.57529 1.000 93.75145  ? 103 TYR B O   1 
ATOM 819  C CB  . TYR A 1 103 ? 73.69161 -8.85401  69.60915 1.000 89.45741  ? 103 TYR B CB  1 
ATOM 820  C CG  . TYR A 1 103 ? 73.74070 -9.61466  68.28036 1.000 85.71377  ? 103 TYR B CG  1 
ATOM 821  C CD1 . TYR A 1 103 ? 73.74149 -8.95364  67.04187 1.000 79.44318  ? 103 TYR B CD1 1 
ATOM 822  C CD2 . TYR A 1 103 ? 73.84740 -11.00282 68.27159 1.000 90.78885  ? 103 TYR B CD2 1 
ATOM 823  C CE1 . TYR A 1 103 ? 73.83296 -9.67883  65.82850 1.000 77.44985  ? 103 TYR B CE1 1 
ATOM 824  C CE2 . TYR A 1 103 ? 73.93325 -11.72732 67.07747 1.000 87.66882  ? 103 TYR B CE2 1 
ATOM 825  C CZ  . TYR A 1 103 ? 73.92810 -11.07462 65.86384 1.000 84.11181  ? 103 TYR B CZ  1 
ATOM 826  O OH  . TYR A 1 103 ? 74.01955 -11.85264 64.72382 1.000 80.53407  ? 103 TYR B OH  1 
ATOM 827  N N   . ILE A 1 104 ? 70.51150 -9.93550  69.71216 1.000 94.87721  ? 104 ILE B N   1 
ATOM 828  C CA  . ILE A 1 104 ? 69.55600 -10.98787 69.99907 1.000 94.43538  ? 104 ILE B CA  1 
ATOM 829  C C   . ILE A 1 104 ? 69.77544 -12.12245 69.01974 1.000 93.84098  ? 104 ILE B C   1 
ATOM 830  O O   . ILE A 1 104 ? 70.09174 -11.88819 67.84637 1.000 89.82574  ? 104 ILE B O   1 
ATOM 831  C CB  . ILE A 1 104 ? 68.12374 -10.45175 69.90485 1.000 94.09844  ? 104 ILE B CB  1 
ATOM 832  C CG1 . ILE A 1 104 ? 67.97664 -9.26492  70.83856 1.000 95.63084  ? 104 ILE B CG1 1 
ATOM 833  C CG2 . ILE A 1 104 ? 67.15327 -11.50490 70.29936 1.000 103.17859 ? 104 ILE B CG2 1 
ATOM 834  C CD1 . ILE A 1 104 ? 68.45743 -9.56632  72.23157 1.000 103.58722 ? 104 ILE B CD1 1 
ATOM 835  N N   . GLU A 1 105 ? 69.59596 -13.34279 69.49151 1.000 93.49320  ? 105 GLU B N   1 
ATOM 836  C CA  . GLU A 1 105 ? 69.66832 -14.49135 68.61486 1.000 101.67968 ? 105 GLU B CA  1 
ATOM 837  C C   . GLU A 1 105 ? 68.75213 -15.59230 69.12446 1.000 104.06086 ? 105 GLU B C   1 
ATOM 838  O O   . GLU A 1 105 ? 68.66390 -15.83869 70.33144 1.000 108.52580 ? 105 GLU B O   1 
ATOM 839  C CB  . GLU A 1 105 ? 71.10961 -14.95284 68.48146 1.000 96.42697  ? 105 GLU B CB  1 
ATOM 840  C CG  . GLU A 1 105 ? 71.76520 -14.37093 67.27117 1.000 97.65477  ? 105 GLU B CG  1 
ATOM 841  C CD  . GLU A 1 105 ? 73.05390 -15.03592 66.96280 1.000 103.14299 ? 105 GLU B CD  1 
ATOM 842  O OE1 . GLU A 1 105 ? 73.42136 -15.92515 67.74879 1.000 102.79531 ? 105 GLU B OE1 1 
ATOM 843  O OE2 . GLU A 1 105 ? 73.67647 -14.69989 65.91702 1.000 104.36961 ? 105 GLU B OE2 1 
ATOM 844  N N   . LEU A 1 106 ? 68.06552 -16.23849 68.18717 1.000 99.29112  ? 106 LEU B N   1 
ATOM 845  C CA  . LEU A 1 106 ? 67.01196 -17.17617 68.52897 1.000 105.40946 ? 106 LEU B CA  1 
ATOM 846  C C   . LEU A 1 106 ? 67.59091 -18.43351 69.14821 1.000 109.69512 ? 106 LEU B C   1 
ATOM 847  O O   . LEU A 1 106 ? 68.58603 -18.98519 68.66807 1.000 113.36034 ? 106 LEU B O   1 
ATOM 848  C CB  . LEU A 1 106 ? 66.21737 -17.56465 67.28606 1.000 102.34007 ? 106 LEU B CB  1 
ATOM 849  C CG  . LEU A 1 106 ? 64.86564 -16.91034 67.03641 1.000 99.42481  ? 106 LEU B CG  1 
ATOM 850  C CD1 . LEU A 1 106 ? 64.33190 -17.38006 65.70520 1.000 93.64226  ? 106 LEU B CD1 1 
ATOM 851  C CD2 . LEU A 1 106 ? 63.90236 -17.19578 68.16336 1.000 105.24753 ? 106 LEU B CD2 1 
ATOM 852  N N   . THR A 1 107 ? 66.94655 -18.89846 70.20595 1.000 110.93065 ? 107 THR B N   1 
ATOM 853  C CA  . THR A 1 107 ? 67.20332 -20.24636 70.66231 1.000 111.29589 ? 107 THR B CA  1 
ATOM 854  C C   . THR A 1 107 ? 66.53967 -21.23845 69.71418 1.000 111.04196 ? 107 THR B C   1 
ATOM 855  O O   . THR A 1 107 ? 65.70380 -20.87700 68.88104 1.000 115.29961 ? 107 THR B O   1 
ATOM 856  C CB  . THR A 1 107 ? 66.67837 -20.42352 72.07502 1.000 113.99806 ? 107 THR B CB  1 
ATOM 857  O OG1 . THR A 1 107 ? 65.24504 -20.38911 72.04466 1.000 113.56317 ? 107 THR B OG1 1 
ATOM 858  C CG2 . THR A 1 107 ? 67.19817 -19.28089 72.95939 1.000 110.11746 ? 107 THR B CG2 1 
ATOM 859  N N   . GLU A 1 108 ? 66.91827 -22.51126 69.85264 1.000 115.84164 ? 108 GLU B N   1 
ATOM 860  C CA  . GLU A 1 108 ? 66.31440 -23.55049 69.02352 1.000 119.78081 ? 108 GLU B CA  1 
ATOM 861  C C   . GLU A 1 108 ? 64.83623 -23.71595 69.33092 1.000 117.81897 ? 108 GLU B C   1 
ATOM 862  O O   . GLU A 1 108 ? 64.01938 -23.90454 68.41779 1.000 116.56523 ? 108 GLU B O   1 
ATOM 863  C CB  . GLU A 1 108 ? 67.02378 -24.88584 69.21524 1.000 117.78797 ? 108 GLU B CB  1 
ATOM 864  C CG  . GLU A 1 108 ? 66.49672 -25.93416 68.25404 1.000 131.01760 ? 108 GLU B CG  1 
ATOM 865  C CD  . GLU A 1 108 ? 67.32722 -27.21241 68.19540 1.000 146.03537 ? 108 GLU B CD  1 
ATOM 866  O OE1 . GLU A 1 108 ? 66.99929 -28.07570 67.35128 1.000 148.19782 ? 108 GLU B OE1 1 
ATOM 867  O OE2 . GLU A 1 108 ? 68.29280 -27.36487 68.97737 1.000 149.21792 ? 108 GLU B OE2 1 
ATOM 868  N N   . LYS A 1 109 ? 64.47641 -23.68525 70.61534 1.000 114.79817 ? 109 LYS B N   1 
ATOM 869  C CA  . LYS A 1 109 ? 63.06919 -23.78663 70.96239 1.000 115.23226 ? 109 LYS B CA  1 
ATOM 870  C C   . LYS A 1 109 ? 62.25737 -22.75288 70.20320 1.000 117.28087 ? 109 LYS B C   1 
ATOM 871  O O   . LYS A 1 109 ? 61.20002 -23.07117 69.64681 1.000 120.94311 ? 109 LYS B O   1 
ATOM 872  C CB  . LYS A 1 109 ? 62.86933 -23.62516 72.46592 1.000 111.88842 ? 109 LYS B CB  1 
ATOM 873  C CG  . LYS A 1 109 ? 61.40279 -23.63470 72.83625 1.000 112.08576 ? 109 LYS B CG  1 
ATOM 874  C CD  . LYS A 1 109 ? 61.16261 -23.79504 74.31455 1.000 110.35576 ? 109 LYS B CD  1 
ATOM 875  C CE  . LYS A 1 109 ? 61.85920 -22.71754 75.09666 1.000 116.09092 ? 109 LYS B CE  1 
ATOM 876  N NZ  . LYS A 1 109 ? 61.29248 -22.58866 76.46767 1.000 122.90689 ? 109 LYS B NZ  1 
ATOM 877  N N   . GLY A 1 110 ? 62.75475 -21.51714 70.13809 1.000 112.33659 ? 110 GLY B N   1 
ATOM 878  C CA  . GLY A 1 110 ? 62.03525 -20.49005 69.40978 1.000 111.96323 ? 110 GLY B CA  1 
ATOM 879  C C   . GLY A 1 110 ? 61.85092 -20.83763 67.94494 1.000 113.63390 ? 110 GLY B C   1 
ATOM 880  O O   . GLY A 1 110 ? 60.76284 -20.66397 67.38283 1.000 111.36327 ? 110 GLY B O   1 
ATOM 881  N N   . GLU A 1 111 ? 62.90487 -21.35189 67.30795 1.000 112.34722 ? 111 GLU B N   1 
ATOM 882  C CA  . GLU A 1 111 ? 62.79641 -21.72103 65.90155 1.000 114.69000 ? 111 GLU B CA  1 
ATOM 883  C C   . GLU A 1 111 ? 61.71464 -22.77820 65.67817 1.000 123.16271 ? 111 GLU B C   1 
ATOM 884  O O   . GLU A 1 111 ? 60.96487 -22.72292 64.68837 1.000 123.66292 ? 111 GLU B O   1 
ATOM 885  C CB  . GLU A 1 111 ? 64.14045 -22.21772 65.38742 1.000 115.95457 ? 111 GLU B CB  1 
ATOM 886  C CG  . GLU A 1 111 ? 64.15654 -22.34932 63.87833 1.000 128.25732 ? 111 GLU B CG  1 
ATOM 887  C CD  . GLU A 1 111 ? 65.54267 -22.22621 63.28009 1.000 137.41975 ? 111 GLU B CD  1 
ATOM 888  O OE1 . GLU A 1 111 ? 66.51945 -22.15174 64.06315 1.000 139.32879 ? 111 GLU B OE1 1 
ATOM 889  O OE2 . GLU A 1 111 ? 65.65015 -22.22070 62.02786 1.000 134.04820 ? 111 GLU B OE2 1 
ATOM 890  N N   . GLU A 1 112 ? 61.63070 -23.75994 66.57913 1.000 121.39932 ? 112 GLU B N   1 
ATOM 891  C CA  . GLU A 1 112 ? 60.55895 -24.74437 66.49660 1.000 119.61221 ? 112 GLU B CA  1 
ATOM 892  C C   . GLU A 1 112 ? 59.19548 -24.09410 66.64785 1.000 118.19192 ? 112 GLU B C   1 
ATOM 893  O O   . GLU A 1 112 ? 58.24085 -24.48137 65.96461 1.000 122.54192 ? 112 GLU B O   1 
ATOM 894  C CB  . GLU A 1 112 ? 60.75654 -25.82258 67.55913 1.000 127.82192 ? 112 GLU B CB  1 
ATOM 895  C CG  . GLU A 1 112 ? 61.78042 -26.88639 67.22001 1.000 133.14192 ? 112 GLU B CG  1 
ATOM 896  C CD  . GLU A 1 112 ? 61.49972 -27.57348 65.88790 1.000 143.60192 ? 112 GLU B CD  1 
ATOM 897  O OE1 . GLU A 1 112 ? 61.46135 -26.90811 64.82763 1.000 134.29192 ? 112 GLU B OE1 1 
ATOM 898  O OE2 . GLU A 1 112 ? 61.26925 -28.80235 65.92938 1.000 153.80192 ? 112 GLU B OE2 1 
ATOM 899  N N   . VAL A 1 113 ? 59.08290 -23.10969 67.54089 1.000 113.74679 ? 113 VAL B N   1 
ATOM 900  C CA  . VAL A 1 113 ? 57.82330 -22.39973 67.69745 1.000 109.81745 ? 113 VAL B CA  1 
ATOM 901  C C   . VAL A 1 113 ? 57.41759 -21.79245 66.36835 1.000 112.79373 ? 113 VAL B C   1 
ATOM 902  O O   . VAL A 1 113 ? 56.25501 -21.86346 65.95488 1.000 115.60296 ? 113 VAL B O   1 
ATOM 903  C CB  . VAL A 1 113 ? 57.96363 -21.31756 68.77602 1.000 104.26066 ? 113 VAL B CB  1 
ATOM 904  C CG1 . VAL A 1 113 ? 56.80661 -20.35709 68.68580 1.000 97.79727  ? 113 VAL B CG1 1 
ATOM 905  C CG2 . VAL A 1 113 ? 58.08610 -21.92484 70.14166 1.000 110.58282 ? 113 VAL B CG2 1 
ATOM 906  N N   . LEU A 1 114 ? 58.38990 -21.21631 65.66689 1.000 112.57349 ? 114 LEU B N   1 
ATOM 907  C CA  . LEU A 1 114 ? 58.11556 -20.49563 64.43107 1.000 109.78134 ? 114 LEU B CA  1 
ATOM 908  C C   . LEU A 1 114 ? 57.65457 -21.45984 63.34604 1.000 111.15741 ? 114 LEU B C   1 
ATOM 909  O O   . LEU A 1 114 ? 56.65000 -21.22774 62.65652 1.000 114.44269 ? 114 LEU B O   1 
ATOM 910  C CB  . LEU A 1 114 ? 59.39004 -19.75261 64.01520 1.000 112.37693 ? 114 LEU B CB  1 
ATOM 911  C CG  . LEU A 1 114 ? 59.42100 -18.32163 63.46201 1.000 111.01848 ? 114 LEU B CG  1 
ATOM 912  C CD1 . LEU A 1 114 ? 58.57037 -17.38866 64.32008 1.000 101.72256 ? 114 LEU B CD1 1 
ATOM 913  C CD2 . LEU A 1 114 ? 60.85675 -17.81098 63.42340 1.000 103.39693 ? 114 LEU B CD2 1 
ATOM 914  N N   . MET A 1 115 ? 58.35982 -22.58196 63.22341 1.000 112.72009 ? 115 MET B N   1 
ATOM 915  C CA  . MET A 1 115 ? 57.99612 -23.59920 62.24207 1.000 117.03625 ? 115 MET B CA  1 
ATOM 916  C C   . MET A 1 115 ? 56.61310 -24.17872 62.53816 1.000 111.44251 ? 115 MET B C   1 
ATOM 917  O O   . MET A 1 115 ? 55.81385 -24.44631 61.62431 1.000 106.58129 ? 115 MET B O   1 
ATOM 918  C CB  . MET A 1 115 ? 59.04250 -24.70818 62.27373 1.000 116.68129 ? 115 MET B CB  1 
ATOM 919  C CG  . MET A 1 115 ? 60.42252 -24.21728 61.95109 1.000 120.29129 ? 115 MET B CG  1 
ATOM 920  S SD  . MET A 1 115 ? 60.54416 -23.41607 60.35710 1.000 132.91012 ? 115 MET B SD  1 
ATOM 921  C CE  . MET A 1 115 ? 61.91573 -22.31389 60.68443 1.000 121.37958 ? 115 MET B CE  1 
ATOM 922  N N   . LYS A 1 116 ? 56.33042 -24.39352 63.82204 1.000 105.48097 ? 116 LYS B N   1 
ATOM 923  C CA  . LYS A 1 116 ? 55.03742 -24.91148 64.24809 1.000 114.11097 ? 116 LYS B CA  1 
ATOM 924  C C   . LYS A 1 116 ? 53.91591 -23.97695 63.83260 1.000 110.51695 ? 116 LYS B C   1 
ATOM 925  O O   . LYS A 1 116 ? 52.95819 -24.37582 63.16015 1.000 111.19097 ? 116 LYS B O   1 
ATOM 926  C CB  . LYS A 1 116 ? 55.02299 -25.07012 65.77631 1.000 113.03094 ? 116 LYS B CB  1 
ATOM 927  C CG  . LYS A 1 116 ? 55.83679 -26.38090 66.39330 1.000 121.70374 ? 116 LYS B CG  1 
ATOM 928  C CD  . LYS A 1 116 ? 56.04826 -26.23258 68.01218 1.000 128.15906 ? 116 LYS B CD  1 
ATOM 929  C CE  . LYS A 1 116 ? 57.03658 -27.42609 68.55771 1.000 137.13006 ? 116 LYS B CE  1 
ATOM 930  N NZ  . LYS A 1 116 ? 57.52218 -27.32109 70.12331 1.000 131.09331 ? 116 LYS B NZ  1 
ATOM 931  N N   . LEU A 1 117 ? 54.01158 -22.72667 64.27134 1.000 112.37783 ? 117 LEU B N   1 
ATOM 932  C CA  . LEU A 1 117 ? 53.10994 -21.67812 63.81888 1.000 110.44995 ? 117 LEU B CA  1 
ATOM 933  C C   . LEU A 1 117 ? 52.90592 -21.71696 62.30985 1.000 110.73956 ? 117 LEU B C   1 
ATOM 934  O O   . LEU A 1 117 ? 51.78697 -21.54427 61.81892 1.000 113.47101 ? 117 LEU B O   1 
ATOM 935  C CB  . LEU A 1 117 ? 53.67590 -20.34034 64.27954 1.000 108.59374 ? 117 LEU B CB  1 
ATOM 936  C CG  . LEU A 1 117 ? 52.69586 -19.29172 64.78333 1.000 108.60059 ? 117 LEU B CG  1 
ATOM 937  C CD1 . LEU A 1 117 ? 51.68101 -19.91811 65.70830 1.000 111.23274 ? 117 LEU B CD1 1 
ATOM 938  C CD2 . LEU A 1 117 ? 53.53391 -18.28837 65.56131 1.000 102.07741 ? 117 LEU B CD2 1 
ATOM 939  N N   . MET A 1 118 ? 53.96644 -21.98840 61.56045 1.000 109.27107 ? 118 MET B N   1 
ATOM 940  C CA  . MET A 1 118 ? 53.81472 -22.09860 60.11668 1.000 109.25536 ? 118 MET B CA  1 
ATOM 941  C C   . MET A 1 118 ? 52.94171 -23.27375 59.72471 1.000 109.75747 ? 118 MET B C   1 
ATOM 942  O O   . MET A 1 118 ? 52.10732 -23.15612 58.82644 1.000 109.74796 ? 118 MET B O   1 
ATOM 943  C CB  . MET A 1 118 ? 55.17698 -22.20601 59.45158 1.000 113.93107 ? 118 MET B CB  1 
ATOM 944  C CG  . MET A 1 118 ? 55.23054 -21.48205 58.13860 1.000 117.99451 ? 118 MET B CG  1 
ATOM 945  S SD  . MET A 1 118 ? 56.92176 -21.32447 57.60961 1.000 130.70107 ? 118 MET B SD  1 
ATOM 946  C CE  . MET A 1 118 ? 57.66885 -21.19006 59.22747 1.000 118.23107 ? 118 MET B CE  1 
ATOM 947  N N   . GLU A 1 119 ? 53.12841 -24.42510 60.35213 1.000 112.91258 ? 119 GLU B N   1 
ATOM 948  C CA  . GLU A 1 119 ? 52.26283 -25.53734 59.98830 1.000 110.72258 ? 119 GLU B CA  1 
ATOM 949  C C   . GLU A 1 119 ? 50.82915 -25.28643 60.43842 1.000 108.18964 ? 119 GLU B C   1 
ATOM 950  O O   . GLU A 1 119 ? 49.89011 -25.73118 59.77636 1.000 116.51258 ? 119 GLU B O   1 
ATOM 951  C CB  . GLU A 1 119 ? 52.83476 -26.83837 60.54632 1.000 118.20258 ? 119 GLU B CB  1 
ATOM 952  C CG  . GLU A 1 119 ? 52.36111 -27.21393 61.91768 1.000 122.62258 ? 119 GLU B CG  1 
ATOM 953  C CD  . GLU A 1 119 ? 53.15438 -28.37043 62.47792 1.000 128.80258 ? 119 GLU B CD  1 
ATOM 954  O OE1 . GLU A 1 119 ? 52.96475 -28.70148 63.66582 1.000 127.85258 ? 119 GLU B OE1 1 
ATOM 955  O OE2 . GLU A 1 119 ? 53.96484 -28.94721 61.71883 1.000 136.20258 ? 119 GLU B OE2 1 
ATOM 956  N N   . THR A 1 120 ? 50.63561 -24.52986 61.51857 1.000 105.26807 ? 120 THR B N   1 
ATOM 957  C CA  . THR A 1 120 ? 49.30497 -24.08077 61.91615 1.000 108.91817 ? 120 THR B CA  1 
ATOM 958  C C   . THR A 1 120 ? 48.68536 -23.10557 60.91923 1.000 110.96245 ? 120 THR B C   1 
ATOM 959  O O   . THR A 1 120 ? 47.48360 -22.82745 61.00768 1.000 109.81443 ? 120 THR B O   1 
ATOM 960  C CB  . THR A 1 120 ? 49.39328 -23.42653 63.29808 1.000 111.47676 ? 120 THR B CB  1 
ATOM 961  O OG1 . THR A 1 120 ? 50.19270 -24.25714 64.14292 1.000 120.53665 ? 120 THR B OG1 1 
ATOM 962  C CG2 . THR A 1 120 ? 48.01291 -23.21437 63.94043 1.000 108.71435 ? 120 THR B CG2 1 
ATOM 963  N N   . TYR A 1 121 ? 49.46347 -22.58110 59.98025 1.000 112.04995 ? 121 TYR B N   1 
ATOM 964  C CA  . TYR A 1 121 ? 48.96061 -21.54769 59.09011 1.000 106.67965 ? 121 TYR B CA  1 
ATOM 965  C C   . TYR A 1 121 ? 47.88724 -22.08024 58.15521 1.000 101.73523 ? 121 TYR B C   1 
ATOM 966  O O   . TYR A 1 121 ? 48.10916 -23.06538 57.43867 1.000 104.20692 ? 121 TYR B O   1 
ATOM 967  C CB  . TYR A 1 121 ? 50.11160 -20.96126 58.28836 1.000 105.05034 ? 121 TYR B CB  1 
ATOM 968  C CG  . TYR A 1 121 ? 49.74037 -19.74707 57.49292 1.000 100.39577 ? 121 TYR B CG  1 
ATOM 969  C CD1 . TYR A 1 121 ? 49.04117 -18.69736 58.07311 1.000 101.22543 ? 121 TYR B CD1 1 
ATOM 970  C CD2 . TYR A 1 121 ? 50.09986 -19.64699 56.15864 1.000 92.96380  ? 121 TYR B CD2 1 
ATOM 971  C CE1 . TYR A 1 121 ? 48.70924 -17.58934 57.34692 1.000 94.43861  ? 121 TYR B CE1 1 
ATOM 972  C CE2 . TYR A 1 121 ? 49.77362 -18.54761 55.42025 1.000 90.33563  ? 121 TYR B CE2 1 
ATOM 973  C CZ  . TYR A 1 121 ? 49.08093 -17.51888 56.01370 1.000 95.56556  ? 121 TYR B CZ  1 
ATOM 974  O OH  . TYR A 1 121 ? 48.76130 -16.41104 55.26594 1.000 101.07160 ? 121 TYR B OH  1 
ATOM 975  N N   . ASP A 1 122 ? 46.73248 -21.42116 58.16976 1.000 94.18676  ? 122 ASP B N   1 
ATOM 976  C CA  . ASP A 1 122 ? 45.67797 -21.62648 57.18046 1.000 93.46573  ? 122 ASP B CA  1 
ATOM 977  C C   . ASP A 1 122 ? 45.33617 -20.27509 56.59366 1.000 92.40913  ? 122 ASP B C   1 
ATOM 978  O O   . ASP A 1 122 ? 44.83790 -19.39136 57.34594 1.000 92.91798  ? 122 ASP B O   1 
ATOM 979  C CB  . ASP A 1 122 ? 44.44403 -22.28161 57.79358 1.000 93.77453  ? 122 ASP B CB  1 
ATOM 980  C CG  . ASP A 1 122 ? 43.39548 -22.63950 56.75174 1.000 93.85933  ? 122 ASP B CG  1 
ATOM 981  O OD1 . ASP A 1 122 ? 43.75912 -22.80310 55.55848 1.000 87.98976  ? 122 ASP B OD1 1 
ATOM 982  O OD2 . ASP A 1 122 ? 42.20514 -22.72480 57.12437 1.000 98.79085  ? 122 ASP B OD2 1 
ATOM 983  N N   . PRO A 1 123 ? 45.55331 -20.03976 55.30716 1.000 88.61960  ? 123 PRO B N   1 
ATOM 984  C CA  . PRO A 1 123 ? 45.26161 -18.71685 54.74800 1.000 82.31459  ? 123 PRO B CA  1 
ATOM 985  C C   . PRO A 1 123 ? 43.78435 -18.41437 54.74118 1.000 88.72829  ? 123 PRO B C   1 
ATOM 986  O O   . PRO A 1 123 ? 43.35788 -17.29381 55.02958 1.000 88.20305  ? 123 PRO B O   1 
ATOM 987  C CB  . PRO A 1 123 ? 45.79312 -18.83709 53.32711 1.000 82.94389  ? 123 PRO B CB  1 
ATOM 988  C CG  . PRO A 1 123 ? 46.89066 -19.83849 53.44109 1.000 88.67087  ? 123 PRO B CG  1 
ATOM 989  C CD  . PRO A 1 123 ? 46.28605 -20.87919 54.34511 1.000 90.32435  ? 123 PRO B CD  1 
ATOM 990  N N   . THR A 1 124 ? 42.99120 -19.42779 54.42086 1.000 91.78044  ? 124 THR B N   1 
ATOM 991  C CA  . THR A 1 124 ? 41.56676 -19.27649 54.18014 1.000 84.52728  ? 124 THR B CA  1 
ATOM 992  C C   . THR A 1 124 ? 40.83190 -18.80963 55.42351 1.000 82.75277  ? 124 THR B C   1 
ATOM 993  O O   . THR A 1 124 ? 39.66257 -18.43227 55.34442 1.000 81.84261  ? 124 THR B O   1 
ATOM 994  C CB  . THR A 1 124 ? 41.03748 -20.61657 53.71956 1.000 83.88824  ? 124 THR B CB  1 
ATOM 995  O OG1 . THR A 1 124 ? 41.12936 -21.50953 54.82723 1.000 91.62190  ? 124 THR B OG1 1 
ATOM 996  C CG2 . THR A 1 124 ? 41.96641 -21.14935 52.64034 1.000 77.14631  ? 124 THR B CG2 1 
ATOM 997  N N   . LYS A 1 125 ? 41.49797 -18.82860 56.57669 1.000 83.78442  ? 125 LYS B N   1 
ATOM 998  C CA  . LYS A 1 125 ? 40.88447 -18.30484 57.79004 1.000 90.78531  ? 125 LYS B CA  1 
ATOM 999  C C   . LYS A 1 125 ? 41.01764 -16.79122 57.88047 1.000 95.79016  ? 125 LYS B C   1 
ATOM 1000 O O   . LYS A 1 125 ? 40.17317 -16.12294 58.49548 1.000 94.71704  ? 125 LYS B O   1 
ATOM 1001 C CB  . LYS A 1 125 ? 41.51231 -18.95031 59.02021 1.000 95.65529  ? 125 LYS B CB  1 
ATOM 1002 C CG  . LYS A 1 125 ? 41.02942 -20.34048 59.29402 1.000 98.79295  ? 125 LYS B CG  1 
ATOM 1003 C CD  . LYS A 1 125 ? 41.76910 -20.91624 60.46515 1.000 104.68729 ? 125 LYS B CD  1 
ATOM 1004 C CE  . LYS A 1 125 ? 41.45510 -22.38163 60.61196 1.000 112.53085 ? 125 LYS B CE  1 
ATOM 1005 N NZ  . LYS A 1 125 ? 42.48679 -23.08478 61.41804 1.000 115.08600 ? 125 LYS B NZ  1 
ATOM 1006 N N   . ASN A 1 126 ? 42.08381 -16.23223 57.30328 1.000 94.48992  ? 126 ASN B N   1 
ATOM 1007 C CA  . ASN A 1 126 ? 42.36316 -14.81359 57.48136 1.000 92.03502  ? 126 ASN B CA  1 
ATOM 1008 C C   . ASN A 1 126 ? 41.60091 -13.96437 56.47762 1.000 84.36071  ? 126 ASN B C   1 
ATOM 1009 O O   . ASN A 1 126 ? 41.57092 -14.26456 55.27815 1.000 78.69485  ? 126 ASN B O   1 
ATOM 1010 C CB  . ASN A 1 126 ? 43.86196 -14.55995 57.37932 1.000 91.70088  ? 126 ASN B CB  1 
ATOM 1011 C CG  . ASN A 1 126 ? 44.65921 -15.53402 58.20686 1.000 96.19509  ? 126 ASN B CG  1 
ATOM 1012 O OD1 . ASN A 1 126 ? 44.16462 -16.05343 59.20395 1.000 101.28585 ? 126 ASN B OD1 1 
ATOM 1013 N ND2 . ASN A 1 126 ? 45.87115 -15.84298 57.76466 1.000 99.46617  ? 126 ASN B ND2 1 
ATOM 1014 N N   . ALA A 1 127 ? 41.02441 -12.87444 56.98906 1.000 81.28346  ? 127 ALA B N   1 
ATOM 1015 C CA  . ALA A 1 127 ? 40.18180 -11.98903 56.19530 1.000 76.11144  ? 127 ALA B CA  1 
ATOM 1016 C C   . ALA A 1 127 ? 40.90805 -11.45181 54.98113 1.000 81.37515  ? 127 ALA B C   1 
ATOM 1017 O O   . ALA A 1 127 ? 40.48309 -11.68676 53.84300 1.000 87.10605  ? 127 ALA B O   1 
ATOM 1018 C CB  . ALA A 1 127 ? 39.71909 -10.81809 57.04460 1.000 74.43041  ? 127 ALA B CB  1 
ATOM 1019 N N   . VAL A 1 128 ? 41.99317 -10.70405 55.21471 1.000 81.24088  ? 128 VAL B N   1 
ATOM 1020 C CA  . VAL A 1 128 ? 42.65886 -9.94704  54.15949 1.000 70.88614  ? 128 VAL B CA  1 
ATOM 1021 C C   . VAL A 1 128 ? 43.04279 -10.85402 53.00268 1.000 75.93990  ? 128 VAL B C   1 
ATOM 1022 O O   . VAL A 1 128 ? 42.96036 -10.45639 51.83115 1.000 80.03893  ? 128 VAL B O   1 
ATOM 1023 C CB  . VAL A 1 128 ? 43.86953 -9.21522  54.74542 1.000 75.09186  ? 128 VAL B CB  1 
ATOM 1024 C CG1 . VAL A 1 128 ? 44.47900 -8.31157  53.71661 1.000 81.82394  ? 128 VAL B CG1 1 
ATOM 1025 C CG2 . VAL A 1 128 ? 43.45580 -8.45699  55.99851 1.000 77.77827  ? 128 VAL B CG2 1 
ATOM 1026 N N   . PHE A 1 129 ? 43.40383 -12.10548 53.29960 1.000 74.82623  ? 129 PHE B N   1 
ATOM 1027 C CA  . PHE A 1 129 ? 43.67888 -13.05830 52.23026 1.000 70.83928  ? 129 PHE B CA  1 
ATOM 1028 C C   . PHE A 1 129 ? 42.46009 -13.21637 51.32280 1.000 75.80931  ? 129 PHE B C   1 
ATOM 1029 O O   . PHE A 1 129 ? 42.53931 -13.06123 50.08843 1.000 70.80606  ? 129 PHE B O   1 
ATOM 1030 C CB  . PHE A 1 129 ? 44.12543 -14.38472 52.85056 1.000 78.59111  ? 129 PHE B CB  1 
ATOM 1031 C CG  . PHE A 1 129 ? 44.53656 -15.43176 51.84910 1.000 82.98528  ? 129 PHE B CG  1 
ATOM 1032 C CD1 . PHE A 1 129 ? 45.82086 -15.43667 51.32093 1.000 80.32344  ? 129 PHE B CD1 1 
ATOM 1033 C CD2 . PHE A 1 129 ? 43.67148 -16.47077 51.52061 1.000 78.67731  ? 129 PHE B CD2 1 
ATOM 1034 C CE1 . PHE A 1 129 ? 46.20447 -16.40417 50.40866 1.000 86.30135  ? 129 PHE B CE1 1 
ATOM 1035 C CE2 . PHE A 1 129 ? 44.04777 -17.44014 50.62102 1.000 84.76589  ? 129 PHE B CE2 1 
ATOM 1036 C CZ  . PHE A 1 129 ? 45.31948 -17.41292 50.06502 1.000 91.85337  ? 129 PHE B CZ  1 
ATOM 1037 N N   . ASN A 1 130 ? 41.30569 -13.45493 51.93481 1.000 76.59898  ? 130 ASN B N   1 
ATOM 1038 C CA  . ASN A 1 130 ? 40.08196 -13.66168 51.17247 1.000 74.62235  ? 130 ASN B CA  1 
ATOM 1039 C C   . ASN A 1 130 ? 39.69140 -12.40247 50.41182 1.000 74.87833  ? 130 ASN B C   1 
ATOM 1040 O O   . ASN A 1 130 ? 39.34305 -12.46572 49.22647 1.000 77.06008  ? 130 ASN B O   1 
ATOM 1041 C CB  . ASN A 1 130 ? 38.97829 -14.10663 52.12785 1.000 75.62632  ? 130 ASN B CB  1 
ATOM 1042 C CG  . ASN A 1 130 ? 39.20569 -15.53522 52.66374 1.000 80.30866  ? 130 ASN B CG  1 
ATOM 1043 O OD1 . ASN A 1 130 ? 39.73112 -16.42591 51.97051 1.000 76.04165  ? 130 ASN B OD1 1 
ATOM 1044 N ND2 . ASN A 1 130 ? 38.86973 -15.72918 53.92607 1.000 79.24279  ? 130 ASN B ND2 1 
ATOM 1045 N N   . GLY A 1 131 ? 39.79175 -11.24355 51.06631 1.000 77.37920  ? 131 GLY B N   1 
ATOM 1046 C CA  . GLY A 1 131 ? 39.60369 -9.96917  50.37810 1.000 79.88887  ? 131 GLY B CA  1 
ATOM 1047 C C   . GLY A 1 131 ? 40.46489 -9.79559  49.13483 1.000 79.83273  ? 131 GLY B C   1 
ATOM 1048 O O   . GLY A 1 131 ? 40.09809 -9.05806  48.21214 1.000 77.68696  ? 131 GLY B O   1 
ATOM 1049 N N   . ALA A 1 132 ? 41.62063 -10.45022 49.09081 1.000 75.74216  ? 132 ALA B N   1 
ATOM 1050 C CA  . ALA A 1 132 ? 42.48535 -10.28716 47.92867 1.000 75.15161  ? 132 ALA B CA  1 
ATOM 1051 C C   . ALA A 1 132 ? 42.30842 -11.35713 46.85251 1.000 81.28137  ? 132 ALA B C   1 
ATOM 1052 O O   . ALA A 1 132 ? 42.79876 -11.17925 45.72812 1.000 77.97391  ? 132 ALA B O   1 
ATOM 1053 C CB  . ALA A 1 132 ? 43.94064 -10.27708 48.36831 1.000 77.90254  ? 132 ALA B CB  1 
ATOM 1054 N N   . LEU A 1 133 ? 41.65513 -12.47065 47.17760 1.000 80.45287  ? 133 LEU B N   1 
ATOM 1055 C CA  . LEU A 1 133 ? 41.50715 -13.55615 46.20292 1.000 72.49604  ? 133 LEU B CA  1 
ATOM 1056 C C   . LEU A 1 133 ? 40.83964 -13.16262 44.88097 1.000 73.23347  ? 133 LEU B C   1 
ATOM 1057 O O   . LEU A 1 133 ? 41.34790 -13.58542 43.82771 1.000 78.60197  ? 133 LEU B O   1 
ATOM 1058 C CB  . LEU A 1 133 ? 40.78030 -14.73407 46.86595 1.000 68.32051  ? 133 LEU B CB  1 
ATOM 1059 C CG  . LEU A 1 133 ? 41.69253 -15.71725 47.60707 1.000 75.90231  ? 133 LEU B CG  1 
ATOM 1060 C CD1 . LEU A 1 133 ? 40.90707 -16.88981 48.12994 1.000 80.89757  ? 133 LEU B CD1 1 
ATOM 1061 C CD2 . LEU A 1 133 ? 42.74272 -16.20992 46.65618 1.000 74.29082  ? 133 LEU B CD2 1 
ATOM 1062 N N   . PRO A 1 134 ? 39.72152 -12.41974 44.85511 1.000 66.17175  ? 134 PRO B N   1 
ATOM 1063 C CA  . PRO A 1 134 ? 39.21376 -11.88003 43.57701 1.000 71.65495  ? 134 PRO B CA  1 
ATOM 1064 C C   . PRO A 1 134 ? 40.27155 -11.27378 42.68065 1.000 82.36776  ? 134 PRO B C   1 
ATOM 1065 O O   . PRO A 1 134 ? 40.31191 -11.50147 41.46618 1.000 84.59370  ? 134 PRO B O   1 
ATOM 1066 C CB  . PRO A 1 134 ? 38.25640 -10.77622 44.04161 1.000 70.07190  ? 134 PRO B CB  1 
ATOM 1067 C CG  . PRO A 1 134 ? 37.70950 -11.29276 45.25439 1.000 73.79988  ? 134 PRO B CG  1 
ATOM 1068 C CD  . PRO A 1 134 ? 38.80901 -12.06961 45.95352 1.000 76.27559  ? 134 PRO B CD  1 
ATOM 1069 N N   . LEU A 1 135 ? 41.11895 -10.45217 43.26596 1.000 80.19076  ? 135 LEU B N   1 
ATOM 1070 C CA  . LEU A 1 135 ? 42.14965 -9.78605  42.49495 1.000 77.80892  ? 135 LEU B CA  1 
ATOM 1071 C C   . LEU A 1 135 ? 43.15901 -10.80173 41.99196 1.000 78.83066  ? 135 LEU B C   1 
ATOM 1072 O O   . LEU A 1 135 ? 43.65285 -10.69928 40.86158 1.000 78.50269  ? 135 LEU B O   1 
ATOM 1073 C CB  . LEU A 1 135 ? 42.83650 -8.73870  43.37302 1.000 80.23246  ? 135 LEU B CB  1 
ATOM 1074 C CG  . LEU A 1 135 ? 42.07017 -7.47466  43.74177 1.000 72.28774  ? 135 LEU B CG  1 
ATOM 1075 C CD1 . LEU A 1 135 ? 41.16230 -7.81118  44.91256 1.000 81.29824  ? 135 LEU B CD1 1 
ATOM 1076 C CD2 . LEU A 1 135 ? 43.01456 -6.40157  44.14508 1.000 69.68377  ? 135 LEU B CD2 1 
ATOM 1077 N N   . ARG A 1 136 ? 43.46302 -11.80854 42.81984 1.000 79.47052  ? 136 ARG B N   1 
ATOM 1078 C CA  . ARG A 1 136 ? 44.38059 -12.85564 42.39373 1.000 80.53644  ? 136 ARG B CA  1 
ATOM 1079 C C   . ARG A 1 136 ? 43.80955 -13.59483 41.20215 1.000 84.01185  ? 136 ARG B C   1 
ATOM 1080 O O   . ARG A 1 136 ? 44.54776 -13.98834 40.29145 1.000 81.36314  ? 136 ARG B O   1 
ATOM 1081 C CB  . ARG A 1 136 ? 44.64356 -13.83739 43.52788 1.000 77.79392  ? 136 ARG B CB  1 
ATOM 1082 C CG  . ARG A 1 136 ? 45.75579 -14.77466 43.19961 1.000 79.79616  ? 136 ARG B CG  1 
ATOM 1083 C CD  . ARG A 1 136 ? 45.25126 -16.00299 42.51278 1.000 88.81666  ? 136 ARG B CD  1 
ATOM 1084 N NE  . ARG A 1 136 ? 46.34018 -16.91335 42.27336 1.000 102.01816 ? 136 ARG B NE  1 
ATOM 1085 C CZ  . ARG A 1 136 ? 46.27886 -17.93946 41.43970 1.000 115.18691 ? 136 ARG B CZ  1 
ATOM 1086 N NH1 . ARG A 1 136 ? 47.34598 -18.71524 41.31168 1.000 119.91993 ? 136 ARG B NH1 1 
ATOM 1087 N NH2 . ARG A 1 136 ? 45.18367 -18.15513 40.70695 1.000 108.64000 ? 136 ARG B NH2 1 
ATOM 1088 N N   . GLU A 1 137 ? 42.49316 -13.81658 41.21198 1.000 80.85877  ? 137 GLU B N   1 
ATOM 1089 C CA  . GLU A 1 137 ? 41.85062 -14.52648 40.11649 1.000 84.39330  ? 137 GLU B CA  1 
ATOM 1090 C C   . GLU A 1 137 ? 41.85636 -13.71577 38.84135 1.000 85.79113  ? 137 GLU B C   1 
ATOM 1091 O O   . GLU A 1 137 ? 42.14583 -14.24515 37.76873 1.000 82.90778  ? 137 GLU B O   1 
ATOM 1092 C CB  . GLU A 1 137 ? 40.42903 -14.92974 40.48001 1.000 86.65684  ? 137 GLU B CB  1 
ATOM 1093 C CG  . GLU A 1 137 ? 39.74839 -15.64680 39.31453 1.000 101.17796 ? 137 GLU B CG  1 
ATOM 1094 C CD  . GLU A 1 137 ? 40.29570 -17.05504 39.03202 1.000 124.08020 ? 137 GLU B CD  1 
ATOM 1095 O OE1 . GLU A 1 137 ? 41.23615 -17.51836 39.73172 1.000 118.77252 ? 137 GLU B OE1 1 
ATOM 1096 O OE2 . GLU A 1 137 ? 39.77967 -17.69167 38.07634 1.000 137.54982 ? 137 GLU B OE2 1 
ATOM 1097 N N   . LEU A 1 138 ? 41.50750 -12.43619 38.92756 1.000 91.06297  ? 138 LEU B N   1 
ATOM 1098 C CA  . LEU A 1 138 ? 41.48159 -11.62054 37.71913 1.000 85.00188  ? 138 LEU B CA  1 
ATOM 1099 C C   . LEU A 1 138 ? 42.88093 -11.48039 37.14661 1.000 83.67741  ? 138 LEU B C   1 
ATOM 1100 O O   . LEU A 1 138 ? 43.09343 -11.68043 35.94515 1.000 85.80492  ? 138 LEU B O   1 
ATOM 1101 C CB  . LEU A 1 138 ? 40.86666 -10.25254 38.00285 1.000 78.01156  ? 138 LEU B CB  1 
ATOM 1102 C CG  . LEU A 1 138 ? 40.98389 -9.24836  36.85543 1.000 85.70997  ? 138 LEU B CG  1 
ATOM 1103 C CD1 . LEU A 1 138 ? 40.16710 -9.67960  35.65465 1.000 86.22405  ? 138 LEU B CD1 1 
ATOM 1104 C CD2 . LEU A 1 138 ? 40.51304 -7.89296  37.33133 1.000 85.41605  ? 138 LEU B CD2 1 
ATOM 1105 N N   . TYR A 1 139 ? 43.86529 -11.21309 38.01084 1.000 85.54900  ? 139 TYR B N   1 
ATOM 1106 C CA  . TYR A 1 139 ? 45.22151 -10.94599 37.53522 1.000 86.55345  ? 139 TYR B CA  1 
ATOM 1107 C C   . TYR A 1 139 ? 46.04107 -12.21279 37.29516 1.000 88.67447  ? 139 TYR B C   1 
ATOM 1108 O O   . TYR A 1 139 ? 47.08899 -12.15658 36.64501 1.000 92.12814  ? 139 TYR B O   1 
ATOM 1109 C CB  . TYR A 1 139 ? 45.97531 -10.08020 38.53105 1.000 82.66933  ? 139 TYR B CB  1 
ATOM 1110 C CG  . TYR A 1 139 ? 45.43143 -8.71264  38.73067 1.000 80.48082  ? 139 TYR B CG  1 
ATOM 1111 C CD1 . TYR A 1 139 ? 44.96783 -7.97311  37.65059 1.000 81.07026  ? 139 TYR B CD1 1 
ATOM 1112 C CD2 . TYR A 1 139 ? 45.52056 -8.09405  39.95899 1.000 81.72629  ? 139 TYR B CD2 1 
ATOM 1113 C CE1 . TYR A 1 139 ? 44.52306 -6.67508  37.81302 1.000 72.76364  ? 139 TYR B CE1 1 
ATOM 1114 C CE2 . TYR A 1 139 ? 45.08593 -6.80025  40.13593 1.000 83.00062  ? 139 TYR B CE2 1 
ATOM 1115 C CZ  . TYR A 1 139 ? 44.59484 -6.09551  39.06158 1.000 82.02996  ? 139 TYR B CZ  1 
ATOM 1116 O OH  . TYR A 1 139 ? 44.18083 -4.80835  39.28903 1.000 98.74521  ? 139 TYR B OH  1 
ATOM 1117 N N   . GLY A 1 140 ? 45.64810 -13.33963 37.87130 1.000 86.16331  ? 140 GLY B N   1 
ATOM 1118 C CA  . GLY A 1 140 ? 46.51489 -14.48951 37.83661 1.000 87.61380  ? 140 GLY B CA  1 
ATOM 1119 C C   . GLY A 1 140 ? 47.64647 -14.45254 38.84143 1.000 95.75969  ? 140 GLY B C   1 
ATOM 1120 O O   . GLY A 1 140 ? 48.48362 -15.36354 38.85285 1.000 104.22083 ? 140 GLY B O   1 
ATOM 1121 N N   . LYS A 1 141 ? 47.69691 -13.44122 39.69578 1.000 89.36638  ? 141 LYS B N   1 
ATOM 1122 C CA  . LYS A 1 141 ? 48.75014 -13.31794 40.68484 1.000 81.83728  ? 141 LYS B CA  1 
ATOM 1123 C C   . LYS A 1 141 ? 48.21762 -12.41830 41.78412 1.000 80.24136  ? 141 LYS B C   1 
ATOM 1124 O O   . LYS A 1 141 ? 47.31269 -11.61788 41.56367 1.000 85.24677  ? 141 LYS B O   1 
ATOM 1125 C CB  . LYS A 1 141 ? 50.03768 -12.75809 40.06746 1.000 83.21191  ? 141 LYS B CB  1 
ATOM 1126 C CG  . LYS A 1 141 ? 49.75496 -11.61204 39.10729 1.000 89.36831  ? 141 LYS B CG  1 
ATOM 1127 C CD  . LYS A 1 141 ? 50.91828 -11.09085 38.23631 1.000 88.92928  ? 141 LYS B CD  1 
ATOM 1128 C CE  . LYS A 1 141 ? 51.96334 -10.29318 39.00865 1.000 94.96450  ? 141 LYS B CE  1 
ATOM 1129 N NZ  . LYS A 1 141 ? 52.96024 -9.60792  38.11691 1.000 95.64760  ? 141 LYS B NZ  1 
ATOM 1130 N N   . PHE A 1 142 ? 48.78009 -12.55289 42.97263 1.000 80.94910  ? 142 PHE B N   1 
ATOM 1131 C CA  . PHE A 1 142 ? 48.30408 -11.77471 44.10581 1.000 78.68168  ? 142 PHE B CA  1 
ATOM 1132 C C   . PHE A 1 142 ? 48.60870 -10.28986 43.88506 1.000 87.67585  ? 142 PHE B C   1 
ATOM 1133 O O   . PHE A 1 142 ? 49.61457 -9.94689  43.26060 1.000 90.92113  ? 142 PHE B O   1 
ATOM 1134 C CB  . PHE A 1 142 ? 48.97555 -12.25935 45.37997 1.000 74.68974  ? 142 PHE B CB  1 
ATOM 1135 C CG  . PHE A 1 142 ? 48.43245 -13.55552 45.86232 1.000 85.69000  ? 142 PHE B CG  1 
ATOM 1136 C CD1 . PHE A 1 142 ? 47.32148 -13.60637 46.68165 1.000 87.51467  ? 142 PHE B CD1 1 
ATOM 1137 C CD2 . PHE A 1 142 ? 49.01795 -14.74461 45.45300 1.000 94.06034  ? 142 PHE B CD2 1 
ATOM 1138 C CE1 . PHE A 1 142 ? 46.80916 -14.82109 47.10472 1.000 79.52901  ? 142 PHE B CE1 1 
ATOM 1139 C CE2 . PHE A 1 142 ? 48.51362 -15.95047 45.87104 1.000 96.39837  ? 142 PHE B CE2 1 
ATOM 1140 C CZ  . PHE A 1 142 ? 47.40641 -15.98618 46.69994 1.000 92.52572  ? 142 PHE B CZ  1 
ATOM 1141 N N   . PRO A 1 143 ? 47.75352 -9.39197  44.38213 1.000 85.79432  ? 143 PRO B N   1 
ATOM 1142 C CA  . PRO A 1 143 ? 47.93456 -7.95284  44.12088 1.000 77.08380  ? 143 PRO B CA  1 
ATOM 1143 C C   . PRO A 1 143 ? 49.31221 -7.46608  44.54446 1.000 76.91434  ? 143 PRO B C   1 
ATOM 1144 O O   . PRO A 1 143 ? 49.82561 -7.84092  45.59673 1.000 83.49731  ? 143 PRO B O   1 
ATOM 1145 C CB  . PRO A 1 143 ? 46.84223 -7.31510  44.98136 1.000 74.44916  ? 143 PRO B CB  1 
ATOM 1146 C CG  . PRO A 1 143 ? 45.82403 -8.32112  45.00170 1.000 80.40673  ? 143 PRO B CG  1 
ATOM 1147 C CD  . PRO A 1 143 ? 46.53868 -9.62279  45.17858 1.000 83.64202  ? 143 PRO B CD  1 
ATOM 1148 N N   . GLU A 1 144 ? 49.89793 -6.59111  43.73584 1.000 77.67035  ? 144 GLU B N   1 
ATOM 1149 C CA  . GLU A 1 144 ? 51.22531 -6.09901  44.07374 1.000 76.60845  ? 144 GLU B CA  1 
ATOM 1150 C C   . GLU A 1 144 ? 51.13370 -4.89376  44.98434 1.000 75.45483  ? 144 GLU B C   1 
ATOM 1151 O O   . GLU A 1 144 ? 52.08207 -4.60840  45.70806 1.000 81.14512  ? 144 GLU B O   1 
ATOM 1152 C CB  . GLU A 1 144 ? 52.00226 -5.67186  42.83979 1.000 82.43928  ? 144 GLU B CB  1 
ATOM 1153 C CG  . GLU A 1 144 ? 52.58300 -6.78281  42.03910 1.000 94.36892  ? 144 GLU B CG  1 
ATOM 1154 C CD  . GLU A 1 144 ? 53.49072 -6.24859  40.98214 1.000 98.91910  ? 144 GLU B CD  1 
ATOM 1155 O OE1 . GLU A 1 144 ? 54.58798 -6.81581  40.81381 1.000 112.77928 ? 144 GLU B OE1 1 
ATOM 1156 O OE2 . GLU A 1 144 ? 53.19601 -5.15211  40.46531 1.000 87.72117  ? 144 GLU B OE2 1 
ATOM 1157 N N   . ILE A 1 145 ? 50.03396 -4.13101  44.91127 1.000 73.56248  ? 145 ILE B N   1 
ATOM 1158 C CA  . ILE A 1 145 ? 49.87387 -2.91071  45.70430 1.000 80.01726  ? 145 ILE B CA  1 
ATOM 1159 C C   . ILE A 1 145 ? 51.12128 -2.03366  45.63097 1.000 76.64666  ? 145 ILE B C   1 
ATOM 1160 O O   . ILE A 1 145 ? 51.67500 -1.58697  46.64236 1.000 70.89640  ? 145 ILE B O   1 
ATOM 1161 C CB  . ILE A 1 145 ? 49.43245 -3.27959  47.13920 1.000 84.57433  ? 145 ILE B CB  1 
ATOM 1162 C CG1 . ILE A 1 145 ? 50.58264 -3.82869  47.98811 1.000 86.81238  ? 145 ILE B CG1 1 
ATOM 1163 C CG2 . ILE A 1 145 ? 48.14474 -4.10448  47.16590 1.000 73.13664  ? 145 ILE B CG2 1 
ATOM 1164 C CD1 . ILE A 1 145 ? 50.13317 -4.51458  49.22158 1.000 88.32432  ? 145 ILE B CD1 1 
ATOM 1165 N N   . LEU A 1 146 ? 51.54081 -1.74543  44.40209 1.000 74.42589  ? 146 LEU B N   1 
ATOM 1166 C CA  . LEU A 1 146 ? 52.77125 -0.99416  44.21395 1.000 71.69048  ? 146 LEU B CA  1 
ATOM 1167 C C   . LEU A 1 146 ? 52.69393 0.37261   44.84469 1.000 78.61881  ? 146 LEU B C   1 
ATOM 1168 O O   . LEU A 1 146 ? 53.66536 0.83183   45.44355 1.000 78.77757  ? 146 LEU B O   1 
ATOM 1169 C CB  . LEU A 1 146 ? 53.07089 -0.77593  42.75199 1.000 61.44603  ? 146 LEU B CB  1 
ATOM 1170 C CG  . LEU A 1 146 ? 53.87995 -1.80308  42.03189 1.000 74.00733  ? 146 LEU B CG  1 
ATOM 1171 C CD1 . LEU A 1 146 ? 54.42871 -0.97121  40.91079 1.000 68.49619  ? 146 LEU B CD1 1 
ATOM 1172 C CD2 . LEU A 1 146 ? 54.95781 -2.43599  42.92026 1.000 93.72924  ? 146 LEU B CD2 1 
ATOM 1173 N N   . GLU A 1 147 ? 51.58442 1.07672   44.63350 1.000 69.03757  ? 147 GLU B N   1 
ATOM 1174 C CA  . GLU A 1 147 ? 51.47932 2.44048   45.11622 1.000 61.77245  ? 147 GLU B CA  1 
ATOM 1175 C C   . GLU A 1 147 ? 51.79405 2.50376   46.60244 1.000 71.22661  ? 147 GLU B C   1 
ATOM 1176 O O   . GLU A 1 147 ? 52.56328 3.35616   47.05785 1.000 75.59617  ? 147 GLU B O   1 
ATOM 1177 C CB  . GLU A 1 147 ? 50.07671 2.94781   44.80948 1.000 71.25433  ? 147 GLU B CB  1 
ATOM 1178 C CG  . GLU A 1 147 ? 49.80870 3.22002   43.33190 1.000 76.01398  ? 147 GLU B CG  1 
ATOM 1179 C CD  . GLU A 1 147 ? 48.46668 3.89569   43.10657 1.000 78.26908  ? 147 GLU B CD  1 
ATOM 1180 O OE1 . GLU A 1 147 ? 48.11396 4.15789   41.94449 1.000 81.32528  ? 147 GLU B OE1 1 
ATOM 1181 O OE2 . GLU A 1 147 ? 47.72489 4.08899   44.08837 1.000 75.33271  ? 147 GLU B OE2 1 
ATOM 1182 N N   . MET A 1 148 ? 51.24611 1.56475   47.35986 1.000 76.71814  ? 148 MET B N   1 
ATOM 1183 C CA  . MET A 1 148 ? 51.54595 1.43489   48.77927 1.000 77.24512  ? 148 MET B CA  1 
ATOM 1184 C C   . MET A 1 148 ? 53.03910 1.27693   49.01803 1.000 79.38970  ? 148 MET B C   1 
ATOM 1185 O O   . MET A 1 148 ? 53.62049 1.91871   49.89633 1.000 81.20525  ? 148 MET B O   1 
ATOM 1186 C CB  . MET A 1 148 ? 50.79780 0.21940   49.31320 1.000 88.76090  ? 148 MET B CB  1 
ATOM 1187 C CG  . MET A 1 148 ? 50.37236 0.27172   50.74810 1.000 102.24210 ? 148 MET B CG  1 
ATOM 1188 S SD  . MET A 1 148 ? 49.21724 -1.07966  51.13810 1.000 99.21981  ? 148 MET B SD  1 
ATOM 1189 C CE  . MET A 1 148 ? 49.30090 -1.02293  52.92354 1.000 89.25488  ? 148 MET B CE  1 
ATOM 1190 N N   . MET A 1 149 ? 53.67575 0.39464   48.26877 1.000 77.56331  ? 149 MET B N   1 
ATOM 1191 C CA  . MET A 1 149 ? 55.08640 0.16597   48.51340 1.000 79.06392  ? 149 MET B CA  1 
ATOM 1192 C C   . MET A 1 149 ? 55.89416 1.39974   48.18356 1.000 73.88475  ? 149 MET B C   1 
ATOM 1193 O O   . MET A 1 149 ? 56.78911 1.77407   48.93804 1.000 77.03555  ? 149 MET B O   1 
ATOM 1194 C CB  . MET A 1 149 ? 55.56035 -1.02788  47.70827 1.000 84.15057  ? 149 MET B CB  1 
ATOM 1195 C CG  . MET A 1 149 ? 55.01532 -2.26715  48.32234 1.000 86.81754  ? 149 MET B CG  1 
ATOM 1196 S SD  . MET A 1 149 ? 55.98102 -3.70417  47.99482 1.000 99.32351  ? 149 MET B SD  1 
ATOM 1197 C CE  . MET A 1 149 ? 57.62475 -3.01846  48.18701 1.000 98.51595  ? 149 MET B CE  1 
ATOM 1198 N N   . CYS A 1 150 ? 55.58018 2.04750   47.06928 1.000 72.66349  ? 150 CYS B N   1 
ATOM 1199 C CA  . CYS A 1 150 ? 56.21651 3.31198   46.71759 1.000 79.97268  ? 150 CYS B CA  1 
ATOM 1200 C C   . CYS A 1 150 ? 56.15521 4.28519   47.87995 1.000 72.12004  ? 150 CYS B C   1 
ATOM 1201 O O   . CYS A 1 150 ? 57.15105 4.93575   48.24032 1.000 71.62481  ? 150 CYS B O   1 
ATOM 1202 C CB  . CYS A 1 150 ? 55.49880 3.91678   45.51502 1.000 79.16905  ? 150 CYS B CB  1 
ATOM 1203 S SG  . CYS A 1 150 ? 55.73900 3.01934   43.98621 1.000 86.98163  ? 150 CYS B SG  1 
ATOM 1204 N N   . ILE A 1 151 ? 54.97328 4.41216   48.46016 1.000 70.27257  ? 151 ILE B N   1 
ATOM 1205 C CA  . ILE A 1 151 ? 54.79541 5.34549   49.55283 1.000 75.72701  ? 151 ILE B CA  1 
ATOM 1206 C C   . ILE A 1 151 ? 55.68270 4.95760   50.71350 1.000 76.44431  ? 151 ILE B C   1 
ATOM 1207 O O   . ILE A 1 151 ? 56.48224 5.76009   51.20943 1.000 75.64591  ? 151 ILE B O   1 
ATOM 1208 C CB  . ILE A 1 151 ? 53.31924 5.39276   49.95677 1.000 71.03891  ? 151 ILE B CB  1 
ATOM 1209 C CG1 . ILE A 1 151 ? 52.53074 5.95261   48.79834 1.000 72.46973  ? 151 ILE B CG1 1 
ATOM 1210 C CG2 . ILE A 1 151 ? 53.11520 6.19271   51.21127 1.000 75.44639  ? 151 ILE B CG2 1 
ATOM 1211 C CD1 . ILE A 1 151 ? 51.09796 5.83629   48.98968 1.000 77.49152  ? 151 ILE B CD1 1 
ATOM 1212 N N   . VAL A 1 152 ? 55.59469 3.69729   51.12746 1.000 78.18321  ? 152 VAL B N   1 
ATOM 1213 C CA  . VAL A 1 152 ? 56.32278 3.29919   52.31965 1.000 77.42866  ? 152 VAL B CA  1 
ATOM 1214 C C   . VAL A 1 152 ? 57.82351 3.44304   52.05888 1.000 77.45294  ? 152 VAL B C   1 
ATOM 1215 O O   . VAL A 1 152 ? 58.58329 3.78094   52.96630 1.000 73.99809  ? 152 VAL B O   1 
ATOM 1216 C CB  . VAL A 1 152 ? 55.89498 1.87089   52.75797 1.000 74.88968  ? 152 VAL B CB  1 
ATOM 1217 C CG1 . VAL A 1 152 ? 56.82104 1.30436   53.80079 1.000 80.22978  ? 152 VAL B CG1 1 
ATOM 1218 C CG2 . VAL A 1 152 ? 54.48009 1.86278   53.27309 1.000 74.39874  ? 152 VAL B CG2 1 
ATOM 1219 N N   . ARG A 1 153 ? 58.26713 3.25630   50.81323 1.000 76.26212  ? 153 ARG B N   1 
ATOM 1220 C CA  . ARG A 1 153 ? 59.67618 3.47138   50.50823 1.000 75.66564  ? 153 ARG B CA  1 
ATOM 1221 C C   . ARG A 1 153 ? 60.08172 4.90859   50.76630 1.000 77.06842  ? 153 ARG B C   1 
ATOM 1222 O O   . ARG A 1 153 ? 61.02417 5.16480   51.51852 1.000 80.32148  ? 153 ARG B O   1 
ATOM 1223 C CB  . ARG A 1 153 ? 60.02075 3.08419   49.06437 1.000 76.56757  ? 153 ARG B CB  1 
ATOM 1224 C CG  . ARG A 1 153 ? 61.58886 3.07651   48.88459 1.000 82.25547  ? 153 ARG B CG  1 
ATOM 1225 C CD  . ARG A 1 153 ? 62.05994 2.52599   47.50943 1.000 85.73669  ? 153 ARG B CD  1 
ATOM 1226 N NE  . ARG A 1 153 ? 62.67188 1.22071   47.83649 1.000 81.33616  ? 153 ARG B NE  1 
ATOM 1227 C CZ  . ARG A 1 153 ? 62.09641 0.09168   47.36520 1.000 82.18845  ? 153 ARG B CZ  1 
ATOM 1228 N NH1 . ARG A 1 153 ? 60.94071 0.21278   46.61886 1.000 84.70813  ? 153 ARG B NH1 1 
ATOM 1229 N NH2 . ARG A 1 153 ? 62.59806 -1.15345  47.65800 1.000 87.35524  ? 153 ARG B NH2 1 
ATOM 1230 N N   . ASN A 1 154 ? 59.38134 5.86216   50.16227 1.000 73.37522  ? 154 ASN B N   1 
ATOM 1231 C CA  . ASN A 1 154 ? 59.72864 7.24747   50.46148 1.000 71.33956  ? 154 ASN B CA  1 
ATOM 1232 C C   . ASN A 1 154 ? 59.64967 7.53700   51.94415 1.000 72.85812  ? 154 ASN B C   1 
ATOM 1233 O O   . ASN A 1 154 ? 60.31426 8.45159   52.42883 1.000 83.01892  ? 154 ASN B O   1 
ATOM 1234 C CB  . ASN A 1 154 ? 58.83502 8.20837   49.69499 1.000 71.24535  ? 154 ASN B CB  1 
ATOM 1235 C CG  . ASN A 1 154 ? 58.81348 7.89575   48.25172 1.000 78.51899  ? 154 ASN B CG  1 
ATOM 1236 O OD1 . ASN A 1 154 ? 59.64783 7.12062   47.77730 1.000 84.11772  ? 154 ASN B OD1 1 
ATOM 1237 N ND2 . ASN A 1 154 ? 57.83647 8.43048   47.53523 1.000 82.36105  ? 154 ASN B ND2 1 
ATOM 1238 N N   . ILE A 1 155 ? 58.85194 6.78109   52.68277 1.000 75.42759  ? 155 ILE B N   1 
ATOM 1239 C CA  . ILE A 1 155 ? 58.68036 7.13842   54.08349 1.000 76.37343  ? 155 ILE B CA  1 
ATOM 1240 C C   . ILE A 1 155 ? 59.82735 6.57192   54.91045 1.000 76.54226  ? 155 ILE B C   1 
ATOM 1241 O O   . ILE A 1 155 ? 60.44004 7.27842   55.71183 1.000 79.72578  ? 155 ILE B O   1 
ATOM 1242 C CB  . ILE A 1 155 ? 57.31355 6.63415   54.59327 1.000 77.71949  ? 155 ILE B CB  1 
ATOM 1243 C CG1 . ILE A 1 155 ? 56.14216 7.18085   53.75599 1.000 78.16901  ? 155 ILE B CG1 1 
ATOM 1244 C CG2 . ILE A 1 155 ? 57.11234 6.99011   56.04908 1.000 68.55868  ? 155 ILE B CG2 1 
ATOM 1245 C CD1 . ILE A 1 155 ? 55.65685 8.56627   54.07899 1.000 81.35444  ? 155 ILE B CD1 1 
ATOM 1246 N N   . TYR A 1 156 ? 60.17130 5.30968   54.66936 1.000 77.71093  ? 156 TYR B N   1 
ATOM 1247 C CA  . TYR A 1 156 ? 60.97864 4.48939   55.55228 1.000 76.52941  ? 156 TYR B CA  1 
ATOM 1248 C C   . TYR A 1 156 ? 62.38006 4.17751   55.03002 1.000 80.36801  ? 156 TYR B C   1 
ATOM 1249 O O   . TYR A 1 156 ? 63.24657 3.79683   55.83037 1.000 85.81173  ? 156 TYR B O   1 
ATOM 1250 C CB  . TYR A 1 156 ? 60.25393 3.16647   55.82634 1.000 69.13128  ? 156 TYR B CB  1 
ATOM 1251 C CG  . TYR A 1 156 ? 59.10724 3.23183   56.80438 1.000 73.85397  ? 156 TYR B CG  1 
ATOM 1252 C CD1 . TYR A 1 156 ? 57.83155 3.58732   56.40750 1.000 77.62220  ? 156 TYR B CD1 1 
ATOM 1253 C CD2 . TYR A 1 156 ? 59.30212 2.91904   58.15067 1.000 74.63383  ? 156 TYR B CD2 1 
ATOM 1254 C CE1 . TYR A 1 156 ? 56.77390 3.63669   57.33412 1.000 72.27724  ? 156 TYR B CE1 1 
ATOM 1255 C CE2 . TYR A 1 156 ? 58.26052 2.97685   59.06256 1.000 72.43267  ? 156 TYR B CE2 1 
ATOM 1256 C CZ  . TYR A 1 156 ? 57.00532 3.33973   58.64903 1.000 68.52480  ? 156 TYR B CZ  1 
ATOM 1257 O OH  . TYR A 1 156 ? 55.97826 3.37684   59.54933 1.000 74.78131  ? 156 TYR B OH  1 
ATOM 1258 N N   . GLY A 1 157 ? 62.64037 4.27156   53.73305 1.000 73.14348  ? 157 GLY B N   1 
ATOM 1259 C CA  . GLY A 1 157 ? 64.01105 4.11787   53.31778 1.000 78.03344  ? 157 GLY B CA  1 
ATOM 1260 C C   . GLY A 1 157 ? 64.27984 2.77567   52.64542 1.000 83.10552  ? 157 GLY B C   1 
ATOM 1261 O O   . GLY A 1 157 ? 63.66090 1.75209   52.95563 1.000 86.64562  ? 157 GLY B O   1 
ATOM 1262 N N   . ASP A 1 158 ? 65.26065 2.78719   51.74231 1.000 78.22490  ? 158 ASP B N   1 
ATOM 1263 C CA  . ASP A 1 158 ? 65.45478 1.64047   50.87151 1.000 76.82797  ? 158 ASP B CA  1 
ATOM 1264 C C   . ASP A 1 158 ? 66.07203 0.49612   51.63855 1.000 80.04094  ? 158 ASP B C   1 
ATOM 1265 O O   . ASP A 1 158 ? 65.78770 -0.68112  51.37106 1.000 83.82594  ? 158 ASP B O   1 
ATOM 1266 C CB  . ASP A 1 158 ? 66.32161 2.01481   49.68050 1.000 84.42761  ? 158 ASP B CB  1 
ATOM 1267 C CG  . ASP A 1 158 ? 65.89264 3.31182   49.03959 1.000 97.28740  ? 158 ASP B CG  1 
ATOM 1268 O OD1 . ASP A 1 158 ? 65.70640 4.29206   49.78822 1.000 105.15242 ? 158 ASP B OD1 1 
ATOM 1269 O OD2 . ASP A 1 158 ? 65.63141 3.31891   47.80590 1.000 95.76242  ? 158 ASP B OD2 1 
ATOM 1270 N N   . ASP A 1 159 ? 66.87178 0.80787   52.63886 1.000 75.81115  ? 159 ASP B N   1 
ATOM 1271 C CA  . ASP A 1 159 ? 67.35214 -0.28976  53.44839 1.000 83.07336  ? 159 ASP B CA  1 
ATOM 1272 C C   . ASP A 1 159 ? 66.21972 -0.92499  54.22665 1.000 83.15591  ? 159 ASP B C   1 
ATOM 1273 O O   . ASP A 1 159 ? 66.16464 -2.15483  54.35165 1.000 82.90847  ? 159 ASP B O   1 
ATOM 1274 C CB  . ASP A 1 159 ? 68.44325 0.14190   54.39616 1.000 89.42602  ? 159 ASP B CB  1 
ATOM 1275 C CG  . ASP A 1 159 ? 69.21111 -1.04966  54.89337 1.000 105.95483 ? 159 ASP B CG  1 
ATOM 1276 O OD1 . ASP A 1 159 ? 69.24750 -2.06521  54.14604 1.000 99.08607  ? 159 ASP B OD1 1 
ATOM 1277 O OD2 . ASP A 1 159 ? 69.70254 -1.00836  56.03309 1.000 115.15483 ? 159 ASP B OD2 1 
ATOM 1278 N N   . PHE A 1 160 ? 65.31144 -0.10621  54.77258 1.000 86.89631  ? 160 PHE B N   1 
ATOM 1279 C CA  . PHE A 1 160 ? 64.08488 -0.66743  55.33935 1.000 86.37226  ? 160 PHE B CA  1 
ATOM 1280 C C   . PHE A 1 160 ? 63.45163 -1.61270  54.34246 1.000 84.39918  ? 160 PHE B C   1 
ATOM 1281 O O   . PHE A 1 160 ? 63.21796 -2.78957  54.63905 1.000 80.46450  ? 160 PHE B O   1 
ATOM 1282 C CB  . PHE A 1 160 ? 63.10096 0.44539   55.70660 1.000 82.00820  ? 160 PHE B CB  1 
ATOM 1283 C CG  . PHE A 1 160 ? 61.77723 -0.03823  56.25537 1.000 81.48758  ? 160 PHE B CG  1 
ATOM 1284 C CD1 . PHE A 1 160 ? 61.65296 -0.40030  57.58477 1.000 79.56096  ? 160 PHE B CD1 1 
ATOM 1285 C CD2 . PHE A 1 160 ? 60.64149 -0.08249  55.45447 1.000 89.06344  ? 160 PHE B CD2 1 
ATOM 1286 C CE1 . PHE A 1 160 ? 60.43517 -0.80355  58.10344 1.000 79.67293  ? 160 PHE B CE1 1 
ATOM 1287 C CE2 . PHE A 1 160 ? 59.40529 -0.49768  55.98067 1.000 83.12697  ? 160 PHE B CE2 1 
ATOM 1288 C CZ  . PHE A 1 160 ? 59.30952 -0.85568  57.29735 1.000 75.03119  ? 160 PHE B CZ  1 
ATOM 1289 N N   . MET A 1 161 ? 63.27342 -1.13237  53.11929 1.000 81.78207  ? 161 MET B N   1 
ATOM 1290 C CA  . MET A 1 161 ? 62.52216 -1.85896  52.11988 1.000 77.67037  ? 161 MET B CA  1 
ATOM 1291 C C   . MET A 1 161 ? 63.21258 -3.16444  51.72500 1.000 79.04025  ? 161 MET B C   1 
ATOM 1292 O O   . MET A 1 161 ? 62.55819 -4.04366  51.15580 1.000 80.91751  ? 161 MET B O   1 
ATOM 1293 C CB  . MET A 1 161 ? 62.28969 -0.92894  50.91647 1.000 75.97940  ? 161 MET B CB  1 
ATOM 1294 C CG  . MET A 1 161 ? 60.86218 -1.04605  50.38810 1.000 88.21892  ? 161 MET B CG  1 
ATOM 1295 S SD  . MET A 1 161 ? 59.69969 0.04169   51.31714 1.000 90.63114  ? 161 MET B SD  1 
ATOM 1296 C CE  . MET A 1 161 ? 58.14452 -0.69147  50.86889 1.000 93.25957  ? 161 MET B CE  1 
ATOM 1297 N N   . GLU A 1 162 ? 64.50014 -3.33438  52.05318 1.000 75.40727  ? 162 GLU B N   1 
ATOM 1298 C CA  . GLU A 1 162 ? 65.18534 -4.59025  51.71099 1.000 81.90482  ? 162 GLU B CA  1 
ATOM 1299 C C   . GLU A 1 162 ? 64.66910 -5.81536  52.45627 1.000 81.78245  ? 162 GLU B C   1 
ATOM 1300 O O   . GLU A 1 162 ? 65.06419 -6.94297  52.13272 1.000 80.16578  ? 162 GLU B O   1 
ATOM 1301 C CB  . GLU A 1 162 ? 66.70082 -4.49635  51.93565 1.000 85.71109  ? 162 GLU B CB  1 
ATOM 1302 C CG  . GLU A 1 162 ? 67.43193 -3.81579  50.79127 1.000 87.14077  ? 162 GLU B CG  1 
ATOM 1303 C CD  . GLU A 1 162 ? 67.55918 -4.70666  49.55692 1.000 85.99048  ? 162 GLU B CD  1 
ATOM 1304 O OE1 . GLU A 1 162 ? 67.64408 -5.93683  49.67192 1.000 87.35464  ? 162 GLU B OE1 1 
ATOM 1305 O OE2 . GLU A 1 162 ? 67.49958 -4.16769  48.44563 1.000 88.84071  ? 162 GLU B OE2 1 
ATOM 1306 N N   . ILE A 1 163 ? 63.79708 -5.64688  53.43810 1.000 81.81653  ? 163 ILE B N   1 
ATOM 1307 C CA  . ILE A 1 163 ? 63.28341 -6.82589  54.13177 1.000 81.55042  ? 163 ILE B CA  1 
ATOM 1308 C C   . ILE A 1 163 ? 62.36667 -7.62946  53.22946 1.000 85.25020  ? 163 ILE B C   1 
ATOM 1309 O O   . ILE A 1 163 ? 62.22561 -8.84877  53.38361 1.000 87.18235  ? 163 ILE B O   1 
ATOM 1310 C CB  . ILE A 1 163 ? 62.55996 -6.43667  55.42041 1.000 73.46186  ? 163 ILE B CB  1 
ATOM 1311 C CG1 . ILE A 1 163 ? 62.17835 -7.72807  56.12294 1.000 69.90271  ? 163 ILE B CG1 1 
ATOM 1312 C CG2 . ILE A 1 163 ? 61.39652 -5.51771  55.07852 1.000 79.29243  ? 163 ILE B CG2 1 
ATOM 1313 C CD1 . ILE A 1 163 ? 61.87310 -7.60515  57.57398 1.000 79.52281  ? 163 ILE B CD1 1 
ATOM 1314 N N   . PHE A 1 164 ? 61.72881 -6.96990  52.27237 1.000 83.22990  ? 164 PHE B N   1 
ATOM 1315 C CA  . PHE A 1 164 ? 60.84793 -7.69867  51.37719 1.000 79.48985  ? 164 PHE B CA  1 
ATOM 1316 C C   . PHE A 1 164 ? 61.64335 -8.65566  50.51818 1.000 84.48486  ? 164 PHE B C   1 
ATOM 1317 O O   . PHE A 1 164 ? 61.27512 -9.82435  50.35679 1.000 83.56857  ? 164 PHE B O   1 
ATOM 1318 C CB  . PHE A 1 164 ? 60.06626 -6.70032  50.55069 1.000 81.37900  ? 164 PHE B CB  1 
ATOM 1319 C CG  . PHE A 1 164 ? 59.18046 -5.84326  51.38194 1.000 78.16099  ? 164 PHE B CG  1 
ATOM 1320 C CD1 . PHE A 1 164 ? 58.00040 -6.35198  51.89555 1.000 73.39247  ? 164 PHE B CD1 1 
ATOM 1321 C CD2 . PHE A 1 164 ? 59.58677 -4.57895  51.75394 1.000 76.98377  ? 164 PHE B CD2 1 
ATOM 1322 C CE1 . PHE A 1 164 ? 57.18975 -5.58919  52.68264 1.000 74.52453  ? 164 PHE B CE1 1 
ATOM 1323 C CE2 . PHE A 1 164 ? 58.79164 -3.81126  52.54686 1.000 76.93199  ? 164 PHE B CE2 1 
ATOM 1324 C CZ  . PHE A 1 164 ? 57.57919 -4.32246  53.02095 1.000 74.24072  ? 164 PHE B CZ  1 
ATOM 1325 N N   . GLU A 1 165 ? 62.78143 -8.19151  50.01329 1.000 89.99121  ? 165 GLU B N   1 
ATOM 1326 C CA  . GLU A 1 165 ? 63.63564 -9.07798  49.23866 1.000 95.29705  ? 165 GLU B CA  1 
ATOM 1327 C C   . GLU A 1 165 ? 64.23218 -10.16212 50.12912 1.000 96.02825  ? 165 GLU B C   1 
ATOM 1328 O O   . GLU A 1 165 ? 64.29920 -11.34400 49.73798 1.000 97.15049  ? 165 GLU B O   1 
ATOM 1329 C CB  . GLU A 1 165 ? 64.72401 -8.26596  48.53513 1.000 88.81578  ? 165 GLU B CB  1 
ATOM 1330 C CG  . GLU A 1 165 ? 65.51205 -9.07721  47.52978 1.000 99.36780  ? 165 GLU B CG  1 
ATOM 1331 C CD  . GLU A 1 165 ? 64.65256 -9.64957  46.38971 1.000 112.91899 ? 165 GLU B CD  1 
ATOM 1332 O OE1 . GLU A 1 165 ? 63.58337 -9.07005  46.07095 1.000 115.02485 ? 165 GLU B OE1 1 
ATOM 1333 O OE2 . GLU A 1 165 ? 65.03428 -10.71759 45.84438 1.000 113.58101 ? 165 GLU B OE2 1 
ATOM 1334 N N   . ARG A 1 166 ? 64.61920 -9.78797  51.35193 1.000 90.04946  ? 166 ARG B N   1 
ATOM 1335 C CA  . ARG A 1 166 ? 65.20038 -10.76577 52.25798 1.000 88.73260  ? 166 ARG B CA  1 
ATOM 1336 C C   . ARG A 1 166 ? 64.22262 -11.90573 52.49924 1.000 91.49859  ? 166 ARG B C   1 
ATOM 1337 O O   . ARG A 1 166 ? 64.56856 -13.08763 52.35418 1.000 92.48947  ? 166 ARG B O   1 
ATOM 1338 C CB  . ARG A 1 166 ? 65.57994 -10.09112 53.56990 1.000 83.18655  ? 166 ARG B CB  1 
ATOM 1339 C CG  . ARG A 1 166 ? 66.13389 -11.04260 54.59253 1.000 91.57551  ? 166 ARG B CG  1 
ATOM 1340 C CD  . ARG A 1 166 ? 66.74595 -10.31435 55.79235 1.000 90.46540  ? 166 ARG B CD  1 
ATOM 1341 N NE  . ARG A 1 166 ? 67.96542 -9.60482  55.40951 1.000 91.01388  ? 166 ARG B NE  1 
ATOM 1342 C CZ  . ARG A 1 166 ? 69.15128 -10.16895 55.21946 1.000 91.20982  ? 166 ARG B CZ  1 
ATOM 1343 N NH1 . ARG A 1 166 ? 69.28842 -11.48533 55.32632 1.000 83.42983  ? 166 ARG B NH1 1 
ATOM 1344 N NH2 . ARG A 1 166 ? 70.18697 -9.40967  54.87378 1.000 93.82567  ? 166 ARG B NH2 1 
ATOM 1345 N N   . ALA A 1 167 ? 62.96533 -11.56084 52.79109 1.000 92.34986  ? 167 ALA B N   1 
ATOM 1346 C CA  . ALA A 1 167 ? 62.00212 -12.58262 53.16852 1.000 96.36575  ? 167 ALA B CA  1 
ATOM 1347 C C   . ALA A 1 167 ? 61.54107 -13.37785 51.95717 1.000 98.14779  ? 167 ALA B C   1 
ATOM 1348 O O   . ALA A 1 167 ? 61.27241 -14.58111 52.06438 1.000 92.83867  ? 167 ALA B O   1 
ATOM 1349 C CB  . ALA A 1 167 ? 60.82503 -11.94927 53.89035 1.000 87.41148  ? 167 ALA B CB  1 
ATOM 1350 N N   . PHE A 1 168 ? 61.46713 -12.73887 50.78748 1.000 95.32540  ? 168 PHE B N   1 
ATOM 1351 C CA  . PHE A 1 168 ? 61.11630 -13.49197 49.59245 1.000 96.21770  ? 168 PHE B CA  1 
ATOM 1352 C C   . PHE A 1 168 ? 62.12717 -14.59974 49.38875 1.000 99.20526  ? 168 PHE B C   1 
ATOM 1353 O O   . PHE A 1 168 ? 61.77090 -15.78041 49.26598 1.000 102.76473 ? 168 PHE B O   1 
ATOM 1354 C CB  . PHE A 1 168 ? 61.06645 -12.55989 48.37645 1.000 98.61000  ? 168 PHE B CB  1 
ATOM 1355 C CG  . PHE A 1 168 ? 60.82122 -13.26083 47.04611 1.000 106.35403 ? 168 PHE B CG  1 
ATOM 1356 C CD1 . PHE A 1 168 ? 61.85003 -13.88243 46.35824 1.000 112.82260 ? 168 PHE B CD1 1 
ATOM 1357 C CD2 . PHE A 1 168 ? 59.56338 -13.23076 46.45377 1.000 103.32733 ? 168 PHE B CD2 1 
ATOM 1358 C CE1 . PHE A 1 168 ? 61.61273 -14.49664 45.13390 1.000 113.27307 ? 168 PHE B CE1 1 
ATOM 1359 C CE2 . PHE A 1 168 ? 59.33636 -13.83744 45.22336 1.000 99.10560  ? 168 PHE B CE2 1 
ATOM 1360 C CZ  . PHE A 1 168 ? 60.35941 -14.46848 44.57022 1.000 99.09338  ? 168 PHE B CZ  1 
ATOM 1361 N N   . GLU A 1 169 ? 63.40848 -14.23363 49.41301 1.000 104.29521 ? 169 GLU B N   1 
ATOM 1362 C CA  . GLU A 1 169 ? 64.44807 -15.21333 49.13848 1.000 107.43064 ? 169 GLU B CA  1 
ATOM 1363 C C   . GLU A 1 169 ? 64.49491 -16.27250 50.23458 1.000 105.90738 ? 169 GLU B C   1 
ATOM 1364 O O   . GLU A 1 169 ? 64.71732 -17.45404 49.94929 1.000 104.63350 ? 169 GLU B O   1 
ATOM 1365 C CB  . GLU A 1 169 ? 65.79719 -14.50587 49.00435 1.000 105.75494 ? 169 GLU B CB  1 
ATOM 1366 C CG  . GLU A 1 169 ? 65.91775 -13.49388 47.85084 1.000 109.55618 ? 169 GLU B CG  1 
ATOM 1367 C CD  . GLU A 1 169 ? 66.27560 -14.12874 46.51487 1.000 122.97814 ? 169 GLU B CD  1 
ATOM 1368 O OE1 . GLU A 1 169 ? 66.24462 -15.37447 46.42834 1.000 126.83133 ? 169 GLU B OE1 1 
ATOM 1369 O OE2 . GLU A 1 169 ? 66.62074 -13.38023 45.57074 1.000 126.50589 ? 169 GLU B OE2 1 
ATOM 1370 N N   . ASN A 1 170 ? 64.25164 -15.87436 51.49151 1.000 103.25515 ? 170 ASN B N   1 
ATOM 1371 C CA  . ASN A 1 170 ? 64.34445 -16.81945 52.60225 1.000 106.31494 ? 170 ASN B CA  1 
ATOM 1372 C C   . ASN A 1 170 ? 63.21993 -17.84148 52.54590 1.000 105.85943 ? 170 ASN B C   1 
ATOM 1373 O O   . ASN A 1 170 ? 63.42511 -19.02917 52.81849 1.000 104.40688 ? 170 ASN B O   1 
ATOM 1374 C CB  . ASN A 1 170 ? 64.30523 -16.07164 53.93384 1.000 100.32768 ? 170 ASN B CB  1 
ATOM 1375 C CG  . ASN A 1 170 ? 65.54974 -15.25380 54.19378 1.000 95.83571  ? 170 ASN B CG  1 
ATOM 1376 O OD1 . ASN A 1 170 ? 66.51603 -15.29189 53.43503 1.000 95.28321  ? 170 ASN B OD1 1 
ATOM 1377 N ND2 . ASN A 1 170 ? 65.52376 -14.49249 55.28030 1.000 96.90914  ? 170 ASN B ND2 1 
ATOM 1378 N N   . ILE A 1 171 ? 62.01478 -17.38937 52.21534 1.000 106.30059 ? 171 ILE B N   1 
ATOM 1379 C CA  . ILE A 1 171 ? 60.89985 -18.31633 52.06994 1.000 109.63449 ? 171 ILE B CA  1 
ATOM 1380 C C   . ILE A 1 171 ? 61.17112 -19.27114 50.91971 1.000 105.82042 ? 171 ILE B C   1 
ATOM 1381 O O   . ILE A 1 171 ? 61.07549 -20.49456 51.06675 1.000 106.05133 ? 171 ILE B O   1 
ATOM 1382 C CB  . ILE A 1 171 ? 59.57310 -17.55114 51.87210 1.000 109.07947 ? 171 ILE B CB  1 
ATOM 1383 C CG1 . ILE A 1 171 ? 58.92111 -17.09213 53.19131 1.000 107.63185 ? 171 ILE B CG1 1 
ATOM 1384 C CG2 . ILE A 1 171 ? 58.58467 -18.40978 51.12967 1.000 99.05665  ? 171 ILE B CG2 1 
ATOM 1385 C CD1 . ILE A 1 171 ? 59.81432 -16.43873 54.22916 1.000 108.74638 ? 171 ILE B CD1 1 
ATOM 1386 N N   . LYS A 1 172 ? 61.53974 -18.72485 49.76178 1.000 108.14923 ? 172 LYS B N   1 
ATOM 1387 C CA  . LYS A 1 172 ? 61.73913 -19.55441 48.58130 1.000 111.21658 ? 172 LYS B CA  1 
ATOM 1388 C C   . LYS A 1 172 ? 62.79859 -20.62371 48.82591 1.000 113.33274 ? 172 LYS B C   1 
ATOM 1389 O O   . LYS A 1 172 ? 62.58245 -21.80892 48.54407 1.000 116.03277 ? 172 LYS B O   1 
ATOM 1390 C CB  . LYS A 1 172 ? 62.11216 -18.65448 47.40312 1.000 115.01224 ? 172 LYS B CB  1 
ATOM 1391 C CG  . LYS A 1 172 ? 62.92492 -19.30261 46.30254 1.000 119.79704 ? 172 LYS B CG  1 
ATOM 1392 C CD  . LYS A 1 172 ? 63.42015 -18.20322 45.36902 1.000 123.94924 ? 172 LYS B CD  1 
ATOM 1393 C CE  . LYS A 1 172 ? 64.17981 -18.75461 44.17174 1.000 130.33018 ? 172 LYS B CE  1 
ATOM 1394 N NZ  . LYS A 1 172 ? 64.48739 -17.66934 43.19033 1.000 126.82056 ? 172 LYS B NZ  1 
ATOM 1395 N N   . GLU A 1 173 ? 63.93784 -20.22356 49.39209 1.000 114.48916 ? 173 GLU B N   1 
ATOM 1396 C CA  . GLU A 1 173 ? 65.09081 -21.10840 49.46487 1.000 114.96316 ? 173 GLU B CA  1 
ATOM 1397 C C   . GLU A 1 173 ? 64.99283 -22.05347 50.65480 1.000 115.39796 ? 173 GLU B C   1 
ATOM 1398 O O   . GLU A 1 173 ? 65.20012 -23.26743 50.52043 1.000 117.06186 ? 173 GLU B O   1 
ATOM 1399 C CB  . GLU A 1 173 ? 66.34583 -20.25004 49.55393 1.000 114.57602 ? 173 GLU B CB  1 
ATOM 1400 C CG  . GLU A 1 173 ? 66.55815 -19.37520 48.32083 1.000 117.98017 ? 173 GLU B CG  1 
ATOM 1401 C CD  . GLU A 1 173 ? 67.64017 -18.32101 48.51686 1.000 122.26080 ? 173 GLU B CD  1 
ATOM 1402 O OE1 . GLU A 1 173 ? 68.03044 -18.09965 49.69001 1.000 118.09312 ? 173 GLU B OE1 1 
ATOM 1403 O OE2 . GLU A 1 173 ? 68.09290 -17.73788 47.49665 1.000 117.29172 ? 173 GLU B OE2 1 
ATOM 1404 N N   . ASP A 1 174 ? 64.69726 -21.51236 51.83830 1.000 113.95132 ? 174 ASP B N   1 
ATOM 1405 C CA  . ASP A 1 174 ? 64.84831 -22.31178 53.04458 1.000 113.59808 ? 174 ASP B CA  1 
ATOM 1406 C C   . ASP A 1 174 ? 63.77759 -23.39395 53.14957 1.000 112.08238 ? 174 ASP B C   1 
ATOM 1407 O O   . ASP A 1 174 ? 64.03434 -24.46810 53.69971 1.000 116.50171 ? 174 ASP B O   1 
ATOM 1408 C CB  . ASP A 1 174 ? 64.84800 -21.40017 54.27537 1.000 117.77303 ? 174 ASP B CB  1 
ATOM 1409 C CG  . ASP A 1 174 ? 65.91088 -20.26592 54.19980 1.000 116.72003 ? 174 ASP B CG  1 
ATOM 1410 O OD1 . ASP A 1 174 ? 66.67622 -20.19738 53.20711 1.000 115.93693 ? 174 ASP B OD1 1 
ATOM 1411 O OD2 . ASP A 1 174 ? 65.96894 -19.44052 55.15864 1.000 106.93374 ? 174 ASP B OD2 1 
ATOM 1412 N N   . PHE A 1 175 ? 62.58252 -23.14876 52.62105 1.000 115.76232 ? 175 PHE B N   1 
ATOM 1413 C CA  . PHE A 1 175 ? 61.47741 -24.07884 52.79721 1.000 120.28888 ? 175 PHE B CA  1 
ATOM 1414 C C   . PHE A 1 175 ? 60.97257 -24.62409 51.46584 1.000 124.54696 ? 175 PHE B C   1 
ATOM 1415 O O   . PHE A 1 175 ? 61.18713 -24.05222 50.39170 1.000 120.96586 ? 175 PHE B O   1 
ATOM 1416 C CB  . PHE A 1 175 ? 60.28122 -23.45335 53.54643 1.000 115.41646 ? 175 PHE B CB  1 
ATOM 1417 C CG  . PHE A 1 175 ? 60.65150 -22.53352 54.67848 1.000 120.63730 ? 175 PHE B CG  1 
ATOM 1418 C CD1 . PHE A 1 175 ? 61.06060 -21.22984 54.44560 1.000 120.57213 ? 175 PHE B CD1 1 
ATOM 1419 C CD2 . PHE A 1 175 ? 60.57674 -22.98088 55.99115 1.000 129.31348 ? 175 PHE B CD2 1 
ATOM 1420 C CE1 . PHE A 1 175 ? 61.39484 -20.39118 55.50494 1.000 122.43277 ? 175 PHE B CE1 1 
ATOM 1421 C CE2 . PHE A 1 175 ? 60.91267 -22.14879 57.05001 1.000 126.50265 ? 175 PHE B CE2 1 
ATOM 1422 C CZ  . PHE A 1 175 ? 61.31971 -20.85740 56.80838 1.000 123.71962 ? 175 PHE B CZ  1 
ATOM 1423 N N   . ILE A 1 176 ? 60.27100 -25.74999 51.57069 1.000 130.24231 ? 176 ILE B N   1 
ATOM 1424 C CA  . ILE A 1 176 ? 59.60940 -26.38721 50.44420 1.000 133.53940 ? 176 ILE B CA  1 
ATOM 1425 C C   . ILE A 1 176 ? 58.32075 -26.97900 51.01198 1.000 137.14931 ? 176 ILE B C   1 
ATOM 1426 O O   . ILE A 1 176 ? 58.15586 -27.07931 52.23065 1.000 134.28877 ? 176 ILE B O   1 
ATOM 1427 C CB  . ILE A 1 176 ? 60.51375 -27.45371 49.78678 1.000 136.08017 ? 176 ILE B CB  1 
ATOM 1428 C CG1 . ILE A 1 176 ? 60.35807 -27.42659 48.27139 1.000 135.67819 ? 176 ILE B CG1 1 
ATOM 1429 C CG2 . ILE A 1 176 ? 60.20270 -28.83611 50.33343 1.000 140.23123 ? 176 ILE B CG2 1 
ATOM 1430 C CD1 . ILE A 1 176 ? 60.83160 -26.12982 47.65404 1.000 128.98268 ? 176 ILE B CD1 1 
ATOM 1431 N N   . GLU A 1 177 ? 57.37738 -27.33755 50.12807 1.000 140.88983 ? 177 GLU B N   1 
ATOM 1432 C CA  . GLU A 1 177 ? 56.02993 -27.70655 50.56830 1.000 143.30771 ? 177 GLU B CA  1 
ATOM 1433 C C   . GLU A 1 177 ? 55.59756 -29.06877 50.03174 1.000 148.68978 ? 177 GLU B C   1 
ATOM 1434 O O   . GLU A 1 177 ? 55.71217 -29.33984 48.83254 1.000 148.71867 ? 177 GLU B O   1 
ATOM 1435 C CB  . GLU A 1 177 ? 54.99822 -26.62539 50.17005 1.000 140.83423 ? 177 GLU B CB  1 
ATOM 1436 C CG  . GLU A 1 177 ? 54.42752 -26.59075 48.70740 1.000 148.19184 ? 177 GLU B CG  1 
ATOM 1437 C CD  . GLU A 1 177 ? 55.43422 -26.78661 47.55085 1.000 154.21050 ? 177 GLU B CD  1 
ATOM 1438 O OE1 . GLU A 1 177 ? 54.97967 -27.10920 46.42328 1.000 154.10633 ? 177 GLU B OE1 1 
ATOM 1439 O OE2 . GLU A 1 177 ? 56.65778 -26.59867 47.73676 1.000 145.95138 ? 177 GLU B OE2 1 
ATOM 1440 N N   . GLN A 1 178 ? 55.12004 -29.92941 50.93209 1.000 145.17992 ? 178 GLN B N   1 
ATOM 1441 C CA  . GLN A 1 178 ? 54.31961 -31.09311 50.56863 1.000 145.96221 ? 178 GLN B CA  1 
ATOM 1442 C C   . GLN A 1 178 ? 52.92350 -30.96524 51.14123 1.000 147.07531 ? 178 GLN B C   1 
ATOM 1443 O O   . GLN A 1 178 ? 51.93310 -31.32085 50.48880 1.000 142.83115 ? 178 GLN B O   1 
ATOM 1444 C CB  . GLN A 1 178 ? 54.96586 -32.39427 51.07511 1.000 149.66095 ? 178 GLN B CB  1 
ATOM 1445 C CG  . GLN A 1 178 ? 56.11879 -32.89773 50.22577 1.000 154.87884 ? 178 GLN B CG  1 
ATOM 1446 C CD  . GLN A 1 178 ? 55.82929 -32.80617 48.74345 1.000 152.24964 ? 178 GLN B CD  1 
ATOM 1447 O OE1 . GLN A 1 178 ? 54.73540 -33.14939 48.28738 1.000 151.13938 ? 178 GLN B OE1 1 
ATOM 1448 N NE2 . GLN A 1 178 ? 56.81826 -32.36627 47.97718 1.000 148.22938 ? 178 GLN B NE2 1 
ATOM 1449 N N   . ASP A 1 179 ? 52.84339 -30.47851 52.36644 1.000 148.58463 ? 179 ASP B N   1 
ATOM 1450 C CA  . ASP A 1 179 ? 51.62017 -29.99246 52.95390 1.000 145.70626 ? 179 ASP B CA  1 
ATOM 1451 C C   . ASP A 1 179 ? 51.83248 -28.63093 53.60365 1.000 147.80821 ? 179 ASP B C   1 
ATOM 1452 O O   . ASP A 1 179 ? 50.87853 -28.05340 54.14161 1.000 144.50705 ? 179 ASP B O   1 
ATOM 1453 C CB  . ASP A 1 179 ? 51.10519 -31.00904 53.97004 1.000 145.94926 ? 179 ASP B CB  1 
ATOM 1454 C CG  . ASP A 1 179 ? 50.20033 -32.01336 53.34125 1.000 151.91621 ? 179 ASP B CG  1 
ATOM 1455 O OD1 . ASP A 1 179 ? 49.58414 -31.68668 52.30260 1.000 149.90701 ? 179 ASP B OD1 1 
ATOM 1456 O OD2 . ASP A 1 179 ? 50.14790 -33.14999 53.84385 1.000 157.01588 ? 179 ASP B OD2 1 
ATOM 1457 N N   . GLY A 1 180 ? 53.05954 -28.11173 53.58787 1.000 144.93820 ? 180 GLY B N   1 
ATOM 1458 C CA  . GLY A 1 180 ? 53.25226 -26.72574 53.94290 1.000 135.47338 ? 180 GLY B CA  1 
ATOM 1459 C C   . GLY A 1 180 ? 54.58075 -26.28800 54.53258 1.000 138.84961 ? 180 GLY B C   1 
ATOM 1460 O O   . GLY A 1 180 ? 54.78148 -25.08160 54.67121 1.000 140.79953 ? 180 GLY B O   1 
ATOM 1461 N N   . LYS A 1 181 ? 55.49618 -27.19669 54.88177 1.000 140.77637 ? 181 LYS B N   1 
ATOM 1462 C CA  . LYS A 1 181 ? 56.67503 -26.81510 55.66153 1.000 141.34144 ? 181 LYS B CA  1 
ATOM 1463 C C   . LYS A 1 181 ? 57.92667 -27.54415 55.17645 1.000 141.02148 ? 181 LYS B C   1 
ATOM 1464 O O   . LYS A 1 181 ? 57.85914 -28.61794 54.57128 1.000 144.65973 ? 181 LYS B O   1 
ATOM 1465 C CB  . LYS A 1 181 ? 56.48826 -27.08637 57.16679 1.000 143.54337 ? 181 LYS B CB  1 
ATOM 1466 C CG  . LYS A 1 181 ? 56.41662 -28.56890 57.58866 1.000 146.81760 ? 181 LYS B CG  1 
ATOM 1467 C CD  . LYS A 1 181 ? 55.16129 -29.28565 57.08043 1.000 146.89763 ? 181 LYS B CD  1 
ATOM 1468 C CE  . LYS A 1 181 ? 54.90044 -30.59376 57.80470 1.000 141.49763 ? 181 LYS B CE  1 
ATOM 1469 N NZ  . LYS A 1 181 ? 53.56142 -31.14015 57.44590 1.000 143.73763 ? 181 LYS B NZ  1 
ATOM 1470 N N   . LEU A 1 182 ? 59.08112 -26.94392 55.47227 1.000 135.93173 ? 182 LEU B N   1 
ATOM 1471 C CA  . LEU A 1 182 ? 60.38863 -27.49050 55.08250 1.000 135.44814 ? 182 LEU B CA  1 
ATOM 1472 C C   . LEU A 1 182 ? 60.63684 -28.89075 55.61804 1.000 138.13036 ? 182 LEU B C   1 
ATOM 1473 O O   . LEU A 1 182 ? 61.76202 -29.38937 55.58055 1.000 132.42629 ? 182 LEU B O   1 
ATOM 1474 C CB  . LEU A 1 182 ? 61.52207 -26.57536 55.54236 1.000 124.30445 ? 182 LEU B CB  1 
ATOM 1475 C CG  . LEU A 1 182 ? 62.01499 -26.64851 56.99193 1.000 130.96126 ? 182 LEU B CG  1 
ATOM 1476 C CD1 . LEU A 1 182 ? 63.03125 -25.54261 57.21799 1.000 130.67951 ? 182 LEU B CD1 1 
ATOM 1477 C CD2 . LEU A 1 182 ? 60.86490 -26.54169 57.98485 1.000 133.40652 ? 182 LEU B CD2 1 
# 
